NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Diabetes;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE This research will compare the effectiveness and safety of metabolic/bariatric surgery, GLP-1 receptor agonists, and SGLT-2 inhibitors in adults with obesity and type 2 diabetes with respect to metabolic outcomes (weight, blood pressure, and glucose control), microvascular and macrovascular complications, and safety events using rich data from a large and diverse nationwide cohort. Our findings will help patients and their clinicians make evidence-informed decisions regarding the risks and benefits of surgical and medical approaches to reduce the long-term complications of concurrent obesity and type 2 diabetes.

PI_NAMEs: ARTERBURN, DAVID ERIC (contact);MCCOY, ROZALINA GRUBINA

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;adult obesity;Affect;Age;Agonist;alternative treatment;American;bariatric surgery;Benefits and Risks;blood glucose regulation;Blood Pressure;Blood Vessels;Body Weight decreased;Cessation of life;Clinical;Clinical Practice Guideline;Clinical Trials;cohort;comorbidity;comparative effectiveness;Comparative Effectiveness Research;comparative effectiveness study;comparative safety;compare effectiveness;Complications of Diabetes Mellitus;cost;Data;Databases;Diabetes Mellitus;diabetes mellitus therapy;Diabetic Ketoacidosis;Disease Progression;Effectiveness;Electronic Health Record;Eligibility Determination;Emergency Care;Emergency department visit;Enrollment;ethnic minority;ethnic minority population;Ethnic Origin;Event;Fee-for-Service Plans;Gastrectomy;Gastric Bypass;Gender;Genitourinary System Infection;GLP-I receptor;glucagon-like peptide 1;Glucose;glycemic control;Glycosylated hemoglobin A;hazard;Head;high risk population;Hospitalization;hospitalization rates;Hyperglycemia;Hypoglycemia;improved;Incidence;inhibitor;Insurance Coverage;Kidney;Kidney Diseases;Knowledge;Life Style;Link;Longitudinal Studies;macrovascular disease;Medical;Medicare;Metabolic;Microvascular Dysfunction;mortality;Non-Insulin-Dependent Diabetes Mellitus;obese patients;Obesity;obesity management;obesity treatment;Operative Surgical Procedures;Outcome;patient population;patient subsets;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacological Treatment;prevent;prospective;Race;racial minority;racial minority population;randomized trial;Randomized, Controlled Trials;Recommendation;Repeat Surgery;Research;Research Design;research study;Risk;rural dwellers;Safety;safety outcomes;safety study;Sample Size;Sampling;Selection for Treatments;Severities;Sodium;Subgroup;surgical risk;symporter;Therapeutic;Treatment Cost;uptake;Weight;Weight maintenance regimen;Work

PROJECT_TITLE: Comparative Effectiveness and Safety of Metabolic/Bariatric Surgery, GLP-1, and SGLT-2 Medications for Patients with Obesity and Type 2 Diabetes

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE The goal of this proposal is to identify novel mechanisms by which genetic variation gives rise to behavioral variation in behaviors comorbid with substance use disorders. We take a circuit-based approach and combine systems neuroscience with mouse genetics to find genes that causally alter the behavioral function of defined circuits in the brain. These results will provide new biological models to explain how DNA variants affect psychiatric disorder risk in humans.

PI_NAMEs: FLINT, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Address;Affect;Anatomy;Anions;anxiety-related behavior;Behavior;behavior test;Behavioral;Biological;Biological Assay;Biological Models;Brain;Candidate Disease Gene;causal variant;Chromosome Mapping;comorbidity;Complex;CRISPR/Cas technology;Darkness;Data;design;disorder risk;DNA;Electrophysiology (science);Epigenetic Process;experimental study;Fiber;Genes;Genetic;genetic approach;Genetic Complementation Test;genetic variant;Genetic Variation;genome wide association study;Genotype;Goals;Haplotypes;Heritability;Hippocampus;Human;Hybrids;Hypothalamic structure;Inbred Strain;Inbred Strains Mice;Injections;insertion/deletion mutation;insight;Knock-out;knockout gene;Knockout Mice;Lateral;Light;Maps;Mediating;Mental disorders;model organism;mouse genetics;Mus;Nervous System Physiology;neural;Neurosciences;novel;Nucleotides;optogenetics;Output;Pathway interactions;Phenotype;Physiological;Physiology;Play;preference;Process;Protocols documentation;Quantitative Trait Loci;Reagent;Resolution;Rhodopsin;Role;sex;Site;Slice;Substance Use Disorder;Synaptic Transmission;System;Techniques;Testing;Time;trait;Variant;Vulnerable Populations;Wild Type Mouse

PROJECT_TITLE: Integrating genetic and circuit variation to identify genes involved in behaviors related to substance use disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 IXR-N (O1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Statins are among the most effective medications to prevent and treat heart disease, but they are not prescribed routinely to people who would benefit from them, especially racial and ethnic minorities, women, and older adults. This study will use information from electronic health records and focus groups to identify patient, clinician, and health system barriers to statin use. This approach could be used to increase the use of statins as a way to reduce health disparities for millions of high-risk individuals.

PI_NAMEs: RODRIGUEZ, FATIMA  (contact)

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Address;Adherence;Artificial Intelligence;Atherosclerosis;Awareness;biomedical informatics;Black race;Cardiology;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;Categories;Cause of Death;Cessation of life;Characteristics;Cholesterol;Classification;Clinical;clinical application;Clinical Informatics;Collaborations;Community Networks;community partnership;cost;Data;Data Sources;Death Rate;deep learning;design;Diabetes prevention;disability;Disparity;disparity gap;electronic health information;Electronic Health Record;electronic structure;Eligibility Determination;Epidemiology;Equity;ethnic minority;Ethnic Origin;Ethnic Population;Evaluation;evidence base;Face;Focus Groups;Geography;Guidelines;Health;Health Alliance;health communication;health data;health disparity;health equity;Health equity research;Health system;Healthcare;Healthcare Systems;Heart Diseases;high risk;high risk population;Hispanic;Hospitals;implementation framework;implementation science;improved;Infrastructure;innovation;insight;Intervention;Knowledge;large language model;Life;Link;marginalization;Medical center;Methodist Church;Methods;minority health;Modeling;Monitor;multidisciplinary;Myocardial Infarction;Nonprofit Organizations;older adult;Participant;patient population;Patients;Persons;Pharmaceutical Preparations;population health;Population Heterogeneity;Practice Guidelines;prevent;Preventive;Primary Prevention;profiles in patients;Public Health;Qualitative Methods;Qualitative Research;racial difference;racial minority;racial population;recruit;Reduce health disparities;Reporting;Resources;response;Sampling;Secondary Prevention;shared decision making;side effect;Structure;structured data;Text;Therapeutic;therapy design;tool;unstructured data;Veterans Health Administration;virtual platform;Woman

PROJECT_TITLE: Adherence Determinants in the Health Electronic Record Evaluation of Statins (ADHERES)

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Intimate Partner Violence (IPV) is a major global problem that can lead to mental health problems such as depression and PTSD. We propose to test a family-based intervention, Multi-component family Intervention to Lower depression and Address intimate Partner violence (MILAP), that will engage women experiencing IPV, their husbands, and mothers-in-law. If successful, the results of this study can provide an intervention that will improve depression, address IPV, and reduce PTSD, and help us understand the mechanisms via which this intervention works.

PI_NAMEs: ACHARYA, BIBHAV  (contact);SAPKOTA, SABITRI

PROGRAM_OFFICER_NAME: CAMPBELL-ROSEN, HOLLY RENEE

PROJECT_TERMS: Acute;Address;Affect;aged;Ally;Attitude;Behavior;Behavior Therapy;Behavioral;Caring;Cognitive Therapy;Communication;community organizations;Complex;cost;Cost Analysis;Cost Effectiveness Analysis;Counseling;Couples Therapy;Data;Daughter;Divorce;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;empowerment;experience;Family;Family member;Family Relationship;Freedom;Frequencies;Gender;global health;group intervention;Household;Husband;improved;interest;Intervention;Intervention Studies;Interview;intimate partner violence;Laws;Legal;low and middle-income countries;Marital Relationships;Mental Depression;Mental Health;Methods;Mothers;Movement;Nepal;novel;Outcome;Participant;Pathway interactions;Persons;Pilot Projects;pilot test;Play;Policy Maker;Post-Traumatic Stress Disorders;primary outcome;Process;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;Recovery;relationship abuse;Reporting;Research;Research Infrastructure;Role;secondary outcome;self esteem;Services;sexual violence;shared decision making;skills;social;social cognitive theory;Stigmatization;suicidal risk;Symptoms;System;Testing;theories;treatment arm;treatment as usual;Trust;Violence;Vulnerable Populations;Withdrawal;Woman;Work;young woman;Youth

PROJECT_TITLE: A randomized controlled trial of a Multi-component family Intervention to Lower depression and Address intimate Partner violence (MILAP) among young women in Nepal

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-C (01)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE There is growing evidence in many neurological diseases, including traumatic brain injury (TBI), that prolonged activation of the innate immune system rather than repair can instead contribute to disease. It is not understood if or how microglia's impact on neuronal excitability might contribute. This proposal will establish how perineuronal satellite microglia and P2Y12 receptors can modify cell-type specific function in TBI and provide vital information that could influence clinically relevant treatment strategies.

PI_NAMEs: NOLAN, AMBER L (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute;Behavioral;Brain;brain control;brain tissue;case control;cell type;Cells;Chronic;clinically relevant;Cognitive;Cognitive deficits;cognitive function;confocal imaging;CSF1R gene;Data;Disease;Down-Regulation;excitatory neuron;Exhibits;Feedback;Functional disorder;functional improvement;Goals;Human;human tissue;immune activation;Immunofluorescence Immunologic;Impaired cognition;improved;In Vitro;inhibitory neuron;Injury;Innate Immune System;insight;Knockout Mice;Label;Learning;Macrophage;Mediating;Mediator;Microglia;Monitor;mouse model;Mus;Nervous System Disorder;network dysfunction;neural;neuron loss;neuronal cell body;Neuronal Dysfunction;neuronal excitability;Neurons;Occlusion injury;Oranges;patch clamp;Pathogen detection;Pathology;Phagocytosis;pharmacologic;Phenocopy;Preparation;Process;Publishing;receptor;Regulation;repair function;repaired;Reporter Genes;restoration;Reversal Learning;RNA;Role;Signal Pathway;Signal Transduction;Slice;Testing;therapeutic target;Tissues;tomato lectin;Transcript;Transgenic Mice;Transgenic Organisms;Traumatic Brain Injury;treatment strategy;Visualization

PROJECT_TITLE: Satellite Microglia: Role in Maladaptive Network Remodeling after TBI

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: MEMPHIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: RELEVANCE Despite the growing list of new antiseizure drugs, status epilepticus remains the second most common life- threatening neurological emergency and triggers a series of neuropathological changes in survivals that can lead to lifelong epilepsy. Current medications merely provide symptomatic relief and are not effective in > 30% of patients, not to mention the unbearable side effects. The proposed research will uncover neuroinflammatory signaling that is essential to the development of spontaneous seizures, and thus might provide novel druggable targets to prevent epilepsy or modify its progression after status epileptics and other precipitating brain insults.

PI_NAMEs: JIANG, JIANXIONG  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: 3-Dimensional;Ablation;acquired epilepsy;acquired factor;Acute;Adult;Adverse effects;Albumins;Anticonvulsants;Antiepileptogenic;anxiety-like behavior;Astrocytes;Behavioral;Blood - brain barrier anatomy;Blood Cells;Blood Proteins;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;brain endothelial cell;Brain Neoplasms;Brain-Derived Neurotrophic Factor;cell type;Central Nervous System Infections;Chronic;Cognitive deficits;comorbidity;Conscious;Coupled;CREB1 gene;Cyclic AMP;cytokine;Darkness;Death Rate;Development;Dinoprostone;Disease;Disease Progression;drug development;drug discovery;Electroencephalography;Encephalitis;Endothelial Cells;Epilepsy;Epileptogenesis;Etiology;Extravasation;FDA approved;Fluorescein-5-isothiocyanate;fluoro jade;Functional disorder;Funding;Generalized Convulsive Status Epilepticus;Genetic;genetic manipulation;glial activation;Glial Fibrillary Acidic Protein;Gliosis;Goals;Grant;GTP-Binding Protein alpha Subunits, Gs;Hippocampus;HMGB1 gene;Immunoglobulin G;Impairment;In Vitro;in vivo;Infection;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;insight;Interleukin-1 beta;Interleukin-6;Intervention;kainate;knock-down;Leucocytic infiltrate;Life;Light;Mediating;Microglia;Modeling;Modification;Molecular;monocyte;mouse PGE synthase 1;Mus;neuroinflammation;Neurologic;Neurological emergencies;neuron loss;Neurons;neuropathology;neurotoxic;neurovascular;neurovascular unit;new therapeutic target;novel;object recognition;occludin;Outcome;Pathologic;Pathway interactions;Patients;Pericytes;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;Play;prevent;preventable epilepsy;Prevention;Process;Prostaglandins;Proteins;receptor;Refractory;Regulation;Research;Risk;Risk Factors;Rodent;Role;Seizures;Series;side effect;Signal Pathway;Signal Transduction;Status Epilepticus;Stroke;Tamoxifen;Testing;Tight Junctions;Time;TNF gene;tumor;Work

PROJECT_TITLE: Inflammatory regulation of epileptogenesis after status epilepticus

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Posttraumatic stress disorder (PTSD) is one of the most common and debilitating health conditions among Veterans. Prolonged exposure (PE) is an effective treatment for PTSD that is commonly used in the VA, but it often fails to fully resolve PTSD in Veteran patients. Inhibitory learning is thought to be a driving force behind symptom reduction in exposure-based therapies like PE, but its role in PE has yet to be evaluated. By establishing inhibitory learning as a mechanism of PTSD improvement during PE, this study will validate a new therapeutic target that can be used to make PE a more effective and precise treatment. Additionally, by showing that inhibitory learning abilities at pretreatment predict PTSD improvement during PE, this study may produce a novel tool for determining which patients to enroll in PE. In this way, the proposed study has the potential to enhance the effectiveness of PE for all Veteran PTSD patients and yield an innovative method for identifying the specific Veterans who are most likely to benefit from this commonly used intervention.

PI_NAMEs: HUNT, CHRISTOPHER  (contact)

PROJECT_TERMS: Accidents;Acute;Address;Anxiety;Anxiety Disorders;anxiety treatment;Area;Arousal;Automobile Driving;Aversive Stimulus;Behavioral;career;Cellular Phone;Clinical;clinical predictors;Clinical Research;Cognitive;Collection;Conscious;Data;Distress;driving force;DSM-V;effective therapy;Effectiveness;effectiveness evaluation;Emotional;Enrollment;Expectancy;expectation;experience;Exposure to;Extinction;Fright;Future;habituation;Health;Health Technology;Heart Rate;improved;in vivo;indexing;innovation;Intervention;Investigation;Knowledge;Laboratories;Learning;learning ability;longitudinal design;Measures;Memory;Mentors;Mentorship;Methods;mHealth;Modeling;multimodality;Neurosciences;new therapeutic target;novel;novel therapeutic intervention;Outcome;Participant;Patients;Physiological;Post-Traumatic Stress Disorders;Prediction of Response to Therapy;Process;Psychophysiology;Psychotherapy;reduce symptoms;Research;Research Personnel;research study;response;Role;Running;smart watch;standard care;Symptoms;telehealth;therapeutic biomarker;Time;tool;Training;Trauma;treatment trial;Update;Veterans;Work

PROJECT_TITLE: Inhibitory Learning as a Novel Mechanism of Prolonged Exposure: An Investigation of Laboratory and Mobile Health Measures

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 MHBP-F (01)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Orphan Drug;Patient Safety;Precision Medicine;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative The achievement of this project forms a basis of combining non-invasive imaging biomarkers with miRNAs, HPV, clinical, and histopathologic biomarkers for accurate cancer prognosis and discovering the correlation with genetic mechanisms leading to specific tumor phenotypes. This clinical decision-making tool can provide useful information to support patient stratification and individualized treatment. We anticipate that many of the methodological improvements established in this proposal will improve oropharyngeal squamous cell carcinoma treatment and tumor response assessment and treatment in other disease sites as well.

PI_NAMEs: LI, HUA  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Achievement;Automobile Driving;Biological Markers;biomarker identification;cancer biomarkers;cancer epidemiology;Cancer Patient;Cancer Prognosis;cancer therapy;cancer type;Clinical;clinical application;clinical biomarkers;clinical decision-making;Clinical Treatment;clinically relevant;Code;cohort;Computer Models;Data;Decision Making;Dimensions;Disease;Disease Progression;effective therapy;Family;Future;Genes;Genetic;Goals;Habitats;Head and Neck Cancer;Heterogeneity;high dimensionality;high risk;HPV negative;HPV oropharyngeal cancer;Human Papillomavirus;Image;imaging biomarker;Imaging Techniques;improved;Incidence;individualized medicine;International;Machine Learning;malignant oropharynx neoplasm;Medical Imaging;Methodology;microRNA biomarkers;MicroRNAs;Modeling;mortality risk;multimodality;Nature;non-invasive imaging;novel;Oncogenic;Oropharyngeal Neoplasms;Oropharyngeal Squamous Cell Carcinoma;Outcome;outcome prediction;patient biomarkers;patient prognosis;patient stratification;patient subsets;Patients;Phenotype;Play;precision oncology;predictive modeling;Prognosis;prognostic;Prognostic Marker;prognostic model;prognostic value;Proteins;Research;response;Retrospective Studies;Risk;Role;Site;Survival Rate;Techniques;Testing;Therapeutic;tool;Treatment Failure;Treatment outcome;treatment strategy;tumor;Uncertainty;United States;Untranslated RNA;Validation;Variant

PROJECT_TITLE: Multimodal Biomarkers For Oropharyngeal Cancer

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The molecular progression of Alzheimer’s Disease (AD) as measured by amyloidosis (Abeta) and tauopathy post mortem has not yet been explicitly linked to clinical biomarkers for measuring neurodegeneration, which renders in vivo diagnosis and effective intervention a challenge. Following the 2018 research framework published by the National Institute of Aging (NIA) and the Alzheimer’s Association (AA), MRI biomarkers have gained particular interest as non-invasive measures shown to correlate with clinical progression of AD; yet, they have not been shown to be specific to AD as current analytical tools remain inadequate for linking 3D macroscopic measures to underlying 2D microscopic measures of tau/Abeta. This work proposes to build a multi-modal, multi-scale image registration and analysis platform to integrate and correlate imaging data from 2D histology images and 3D MRI to establish the specificity of MRI biomarkers for AD and thereby enable their use in clinical practice.

PI_NAMEs: STOUFFER, KAITLIN  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;Amyloidosis;analytical tool;Area;Atlases;Autopsy;beta amyloid pathology;Biological Markers;Brain;brain control;brain tissue;brain volume;Categories;Clinical;clinical biomarkers;clinical practice;Communities;computational anatomy;Computer Models;computerized tools;convolutional neural network;Correlation Studies;Data;data integration;data modeling;Data Set;density;design;Development;Diagnosis;digital;digital data;Dimensions;Disease;disorder risk;Early identification;effective intervention;entorhinal cortex;Filament;Frequencies;Future;generative models;Glean;Goals;high resolution imaging;Histologic;histological specimens;Histology;Human;human old age (65+);Image;Image Analysis;image registration;improved;in vivo;Individual;interest;Link;Literature;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Manuals;Mathematics;Measures;medial temporal lobe;Methods;Microscopic;Modeling;Molecular;Morphologic artifacts;MRI Scans;multi-scale imaging data;multimodality;multiscale data;Mus;National Institute on Aging;Nerve Degeneration;Neurofibrillary Tangles;neuroimaging;novel;open source;Pathologic;Pathology;Pattern;Phase;PHF-1;Prevalence;Publishing;Research;Resolution;Resources;Sampling;Senile Plaques;Series;Shapes;Spatial Distribution;specific biomarkers;Specificity;Stains;Statistical Distributions;Statistical Models;statistics;stem;success;Surface;Symptoms;Targeted Research;tau Proteins;Tauopathies;Techniques;Testing;Texture;Thick;Tissues;tool;Training;trend;white matter;Work

PROJECT_TITLE: Fluency from Flesh to Filament: Collation, Representation, and Analysis of Multi-Scale Neuroimaging data to Characterize and Diagnose Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-Y(20)L]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Alzheimer's Disease and Corticobasal degeneration are 2 of more than 20 “tauopathies” that are characterized by different forms of fibrillar tau aggregates and lack basic understanding of mechanism of neurotoxicity, disease development, and disease progression. Valosin-containing protein is an essential factor in proteostasis, the regulation and balance of the proteome, through removing proteins from complexes, membranes, and aggregates such as those formed by fibrillar tau and has recently been linked with a newly discovered tauopathy. This application proposes to obtain the first structures of valosin-containing protein with brain-derived tau fibrils from Alzheimer's Disease and Corticobasal degeneration patients and probe the mechanism of how valosin-containing protein interacts with brain-derived and recombinant tau fibrils.

PI_NAMEs: CREEKMORE, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 26S proteasome;Affect;Alzheimer's Disease;ATP phosphohydrolase;Autophagocytosis;Autopsy;Binding;Binding Proteins;Brain;Cell Physiology;Cells;Clinical;cofactor;Complex;corticobasal degeneration;Cryo-electron tomography;Cryoelectron Microscopy;Data;Dementia;Development;Disease;Disease Progression;Drug Targeting;Endosomes;Equilibrium;Excision;Fluorescence;Functional disorder;Goals;Homeostasis;Hybrids;Image;Impaired cognition;In Vitro;Individual;insight;Label;Light;Link;link protein;Mediating;Membrane;Methods;Microscopy;Mitochondria;Modeling;Molecular Conformation;monomer;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neurotoxicity;particle;Pathology;Patients;Play;Productivity;protein complex;protein function;Protein Region;Proteins;Proteome;proteostasis;Reaction;reaction rate;Recombinants;Regulation;Role;stoichiometry;Structure;tau aggregation;tau interaction;tau Proteins;Tauopathies;Testing;Therapeutic;Time;trafficking;Ubiquitin;Ubiquitination;valosin containing protein mutation;valosin-containing protein

PROJECT_TITLE: Mechanism of VCP interaction and processing of neurodegenerative tau fibrils


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness;Suicide;Suicide Prevention

ORG_CITY: BURLINGAME

ORG_NAME: MAGNUS MEDICAL INC

PHR: PROJECT NARRATIVE We recently developed a form of neuromodulation termed SAINT that induces remission in 90% of individuals with treatment-resistant depression. SAINT-induced remission is associated with significant reductions in explicit suicidal cognition. This project aims to elucidate the nature of the suicidal cognition changes produced by applying SAINT to the DLPFC-sgACC of acutely suicidal inpatients.

PI_NAMEs: BENTZLEY, BRANDON S (contact);WILLIAMS, NOLAN R.

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acceleration;Acute;Admission activity;Anhedonia;Anterior;anti-depressive agents;antidepressant effect;Brain;Caring;cingulate cortex;Cognition;Cognitive;Coupled;Data;Depressed mood;depressive symptoms;design;Development;efficacy evaluation;efficacy testing;Electroconvulsive Therapy;Eligibility Determination;FDA approved;Feeling hopeless;Feeling suicidal;Future;Hospitalization;Hospitals;implementation intervention;Implicit Association Test;improved;indexing;Individual;innovation;inpatient psychiatric treatment;Inpatients;Intervention;Ketamine;Learning;Left;Length;Mediating;Mediator;Mental Depression;Methods;modifiable risk;Moods;Nature;neural circuit;Neurobiology;neuroregulation;novel;Outcome;Outpatients;Patients;Pattern;Physiologic pulse;Pilot Projects;Prefrontal Cortex;preservation;prospective;Protocols documentation;psychiatric emergency;psychiatric inpatient;Publishing;randomized trial;Randomized, Controlled Trials;reducing suicide;Remission Induction Therapy;repetitive transcranial magnetic stimulation;Rest;Safety;Schedule;side effect;Signal Transduction;social stigma;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Sum;symptom treatment;symptomatic improvement;theories;Therapeutic;Therapeutic Effect;Time;treatment-resistant depression;ward

PROJECT_TITLE: The Effects of Stanford Accelerated Intelligent Neuromodulation Therapy on Explicit and Implicit Suicidal Cognition


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Tuberculosis remains of utmost public health concern globally and domestically, with escalating public health threats including relentless global increase in multi-drug-resistance, disability even after the cure, and global pandemics. The ‘syndemic’ of tuberculosis and HIV/AIDS and the ongoing coronavirus pandemic adds complexity to public health control. In this proposal, we seek to harness the powerful process called autophagy, an endogenous anti-microbial defense and tissue-protective mechanism available to every cell in the body. We have developed the concept that autophagy and its component Atg8ylation can clear the intracellular bacteria and protect lungs against M. tuberculosis-induced pathology. To unleash this internal power that our cells possess, we will identify specific proteins and processes carrying out autophagic control of M. tuberculosis, suppression of inflammation, and protection against active disease. This will enable us and others to develop new autophagy-based therapies and drugs to prevent and treat tuberculosis.

PI_NAMEs: DERETIC, VOJO P (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Anti-Bacterial Agents;Anti-Inflammatory Agents;antimicrobial;antiretroviral therapy;Antitubercular Antibiotics;Autophagocytosis;Award;Bacteria;Cell membrane;Cells;chemotherapy;Chronic;Communities;coronavirus pandemic;Defense Mechanisms;Development;disability;Disease;experience;Guanosine Triphosphate Phosphohydrolases;HIV/AIDS;HIV/TB;Homeostasis;Human;human pathogen;Immune;immune reconstitution;Immune signaling;Immunity;Impairment;improved;Individual;Inflammation;Inflammatory;insight;Knowledge;Linezolid;Link;Long term disability;Lung;lung injury;Macrophage;Membrane;Metabolic;Minor;Molecular;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;Mycobacterium tuberculosis;Natural Immunity;pandemic disease;Paper;Pathogenesis;Pathology;Patients;Pattern;Pattern recognition receptor;Persons;Phagosomes;Pharmaceutical Preparations;prevent;Process;programs;Proteins;Public Health;Publications;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Regimen;Reporting;Research;response;Role;Signal Transduction;Structure of parenchyma of lung;syndemic;Syndrome;targeted treatment;therapeutic development;Therapeutic Intervention;Tissues;transmission process;Tuberculosis;tuberculosis chemotherapy;tuberculosis treatment;Update;Virulent;Work

PROJECT_TITLE: Pattern Recognition Receptors and Autophagy in Mtb Control in AIDS

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SANTA CRUZ

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Cells maintain sophisticated mechanisms that ensure replicated chromosomes are accurately transmitted to daughter cells during division. When these mechanisms fail, cancer and other diseases are the result. The studies described in this grant examine an unsuspected and unexplored set of mechanisms that operate during the final stages of cell division (anaphase/telophase) to ensure accurate chromosome transmission.

PI_NAMEs: SULLIVAN, WILLIAM T. (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Anaphase;Behavior;Cell Cycle;Cell division;Cell Nucleus;Cells;Chromatin;chromosome replication;Chromosomes;Congresses;Cytokinesis;Daughter;daughter cell;Disease;DNA;DNA Damage;DNA Repair;Drosophila genus;Electron Microscope;Ensure;Eukaryotic Cell;Excision;fluorescence microscope;Genetic;Genome;genome integrity;Genomics;Goals;Grant;Induction of Apoptosis;Interphase;Kinetochores;Malignant Neoplasms;Metaphase;Microtubules;Mitotic;Molecular;novel;Nuclear Envelope;response;Secure;segregation;Sister;telophase;Time;transmission process

PROJECT_TITLE: Mitotic transmission of acentric chromosome fragments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Gene Therapy;Genetics;Human Genome;Immunotherapy;Infectious Diseases

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: NARRATIVE: The proposed work will provide new insight into the mechanism of T exhaustion in tumors and will provide critical information about the limitations of FDA approved immune checkpoint blockade and CAR T-cell therapy. These mechanistic studies may ultimately translate into novel strategies for improving existing immunotherapies and enhance the durability of anti-tumor immune responses.!

PI_NAMEs: YOUNGBLOOD, BENJAMIN ALAN (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Affinity;anti-tumor immune response;Antigen Presentation;Antigen-Presenting Cells;Antigens;Antitumor Response;Autoimmunity;bisulfite sequencing;cancer infiltrating T cells;cancer type;CAR T cell therapy;CD19 gene;CD8-Positive T-Lymphocytes;Cell division;Cell Maintenance;Cells;Cellular immunotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;chronic infection;Clinical;Coupled;Cross Presentation;demethylating therapy;demethylation;Disease;DNA;DNA Methylation;DNA Methylation Inhibition;DNA methylation profiling;DNA Methyltransferase Inhibitor;DNA Modification Methylases;DNMT3a;effector T cell;engineered T cells;Epigenetic Process;exhaust;exhaustion;FDA approved;Foundations;Gene Expression;Genes;Genome;HER2 inhibition;Heritability;Human;immune checkpoint blockade;Immune system;Immunity;Immunotherapy;improved;In Vitro;in vivo;Infiltration;inhibitor;insight;knock-down;Life;Light;Longevity;lymphoid neoplasm;Lymphoid Tissue;Maintenance;Malignant Neoplasms;Measures;Mediating;Memory;Methods;Methylation;Modification;monocyte;Mus;Mutation;Myeloid Cells;neoplasm immunotherapy;neoplastic cell;novel strategies;pathogen;Patients;PD-1 blockade;pediatric patients;preservation;prevent;programmed cell death protein 1;programs;promoter;Property;Psychological reinforcement;receptor;Receptor Signaling;Rejuvenation;Reporter;Reporting;Repression;Research;response;Signal Transduction;Solid Neoplasm;Source;success;System;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Therapeutic Effect;Transcriptional Regulation;Translating;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Virus;Virus Diseases;Vitiligo;whole genome;Work

PROJECT_TITLE: Epigenetic Reprogramming of T cell Exhaustion To Enhance Tumor Immunotherapy

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: To make and store insulin, pancreatic islet ß-cells must make large quantities of the precursor protein, proinsulin, and fold it properly. However, we have now definitively identified misfolded proinsulin that occurs in the islets of human beings or rodents, and is markedly worse in individuals with insulin gene mutations, or in islets prior to the onset of type 2 diabetes. This proposal aims to understand the mechanism of how proinsulin misfolding occurs, and how to limit its damage, in order to prevent diabetes.

PI_NAMEs: ARVAN, PETER  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Anabolism;Animals;autosome;Beta Cell;Biological;Biological Assay;Blood Circulation;Blood Glucose;Cell Line;Cells;Code;Complex;Coupled;Cysteine;Data;design;Development;Diabetes Mellitus;diabetogenic;dimer;Disease;Dissection;disulfide bond;Disulfides;Dominant-Negative Mutation;endocrine pancreas development;Endoplasmic Reticulum;endoplasmic reticulum stress;Environment;Experimental Designs;experimental study;Failure;Functional disorder;Future;Gene Mutation;genetic approach;Genetic Predisposition to Disease;Grant;Heterozygote;Hormones;Human;in vivo;Individual;INS gene;Insulin;insulin granule;insulin secretion;islet;Islet Cell;Islets of Langerhans;Knock-in;Link;Maps;Metabolic;misfolded protein;Modeling;Molecular;Mus;mutant;Mutant Strains Mice;Mutation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;oxidation;Pathway interactions;Patients;Phenotype;Physiological;Population;Predisposition;preproinsulin;prevent;Process;Proinsulin;protein complex;Protein Precursors;rare condition;response;Rodent;Secretory Vesicles;Series;Structure of beta Cell of islet;Testing;tool;trafficking;Translations;Variant;Vertebral column;Western Blotting;Work;Youth

PROJECT_TITLE: Proinsulin Trafficking for Insulin Biosynthesis

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Nanotechnology;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE CNS cancers such as diffuse intrinsic pontine glioma (DIPG) are notoriously difficult to treat, due to both their anatomical location as well as the lack of highly effective treatment options. To address these issues, our group has identified a common DIPG mutation in the phosphatase PPM1D that confers metabolic defects which can be exploited for therapeutic gain. Using in vitro and in vivo preclinical model systems, this proposal seeks to develop and utilize nanoparticle-encapsulated inhibitors of NAMPT, an NAD biosynthesis enzyme, to target and kill mutant PPM1D cells and tumors with high efficacy and low toxicity.

PI_NAMEs: MURRAY, MATTHEW A. (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Address;Anabolism;Anatomy;Animal Model;Astrocytes;Biocompatible Materials;Biodistribution;Biological Assay;Biological Models;Biomedical Engineering;Blood - brain barrier anatomy;Bone Marrow;Brain;Brain Neoplasms;brain parenchyma;Brain Stem;brain tissue;Cancer cell line;Cause of Death;cell killing;Cell Line;Cell model;Cells;chemotherapy;Clinical;Clinical Trials;Communication;Convection;copolymer;Coupled;CpG Islands;Databases;Defect;Development;Diffuse intrinsic pontine glioma;Dose;Dose Limiting;Drug Delivery Systems;effective therapy;Encapsulated;enzyme biosynthesis;Enzymes;Excision;Formulation;Future;Genes;Goals;Human;Hypermethylation;In Vitro;in vivo;in vivo Model;inhibitor;innovation;Intracranial Neoplasms;Laboratories;Location;Malignant Childhood Neoplasm;Malignant neoplasm of central nervous system;Malignant Neoplasms;Metabolic;Methods;Modeling;Molecular Profiling;mutant;Mutation;nanoparticle;Nature;neoplastic cell;novel;novel therapeutic intervention;Oncogenic;Open Reading Frames;Operative Surgical Procedures;palliative;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphoric Monoester Hydrolases;poly(lactic acid);Polyethylene Glycols;Polymers;Pontine structure;PPM1D gene;pre-clinical;Pre-Clinical Model;promoter;Publishing;Radiation therapy;Research;Retina;Science;Site;small molecule;standard of care;stem;success;Survival Rate;Techniques;Testing;Therapeutic;Time;Toxic effect;tumor;tumor microenvironment;Tumor Volume;Work;Xenograft procedure

PROJECT_TITLE: Exploiting Mutant PPM1D-induced Metabolic Defects with Nanoparticle Encapsulated NAMPT Inhibitors


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Dental caries is one of the most prevalent dysbiotic diseases worldwide. Since caries itself is  irreversible, focus should be on caries prevention. This study aims to understand the role of  commensal streptococci in promoting oral health. Specifically, we will identify how a common  molecular trait of commensal streptococci, the production of H202 by the pyruvate oxidase, can be  used as predictor of caries risk before caries manifestation.

PI_NAMEs: KRETH, JENS  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acids;Actinomyces naeslundii;Aerobic;American Dental Association;Area;Biological Markers;Carbohydrates;Caries prevention;Classification;Clinical;Communities;Complex;Dental caries;Dental Plaque;Detection;Development;Diagnostic;diagnostic accuracy;Dietary Carbohydrates;Disease;disorder prevention;dysbiosis;Early Intervention;Encapsulated;Environment;Enzymes;experience;feeding;Fermentation;Goals;Growth;Guidelines;Health;Health Promotion;Hydrogels;Hydrogen Peroxide;improved;In Vitro;in vivo;innovation;insight;Knowledge;Measurement;Measures;Metabolic;Methods;microbial;Microbial Biofilms;Microscopy;Molecular;molecular marker;Monitor;mouse model;Mouth Diseases;Nature;Oral;oral biofilm;oral commensal;Oral health;Oral Microbiology;oral microbiome;oral streptococci;pathogen;Patients;polymicrobial disease;Population;Post-Translational Protein Processing;pre-clinical;Predisposition;Prevalence;prevent;Prevention;Process;Production;protein protein interaction;Pyruvate Oxidase;Regulation;Research;Resistance;response;Risk;Risk Assessment;Role;Sampling;Scanning;sensor;Streptococcus;Streptococcus mutans;success;Symbiosis;systematic review;Techniques;temporal measurement;Testing;Time;Tooth structure;tooth surface;trait;Transcriptional Regulation

PROJECT_TITLE: Pyruvate oxidase: a molecular determinant of commensalism among the oral microbiome

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Pregnant women and women using oral contraceptive agents(OCA) have a 2-3 times greater risk of thrombosis (spontaneous clotting that blocks blood flow), and obese women using OCA have a dramatic 24 times greater risk of thrombosis. We have identified gene regulatory proteins that suppress expression of a key anti-clotting protein, Protein S. Our project will identify the molecular mechanisms of OCA and obesity-mediated PS suppression and thereby suggest new therapies to mitigate thrombosis in women.

PI_NAMEs: MAJUMDER, RINKU  (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Affect;analog;Anticoagulants;aptamer;Binding;Binding Proteins;biobank;Biochemical;Biological Assay;Blood flow;C57BL/6 Mouse;Cells;ChIP-on-chip;chromatin immunoprecipitation;Chronic;Clinical;Coagulation Process;cohort;Collection;Contraceptive Agents;Data;Deep Vein Thrombosis;Epigenetic Process;ESR1 gene;Estrogen Receptors;estrogenic;Estrogens;experience;Factor IXa;Female;Gene Expression;Gene Proteins;gene repression;Gene Targeting;Generations;Genes;genetic regulatory protein;Genetic Transcription;Gonadal Steroid Hormones;Hemostatic function;HepG2;HIF1A gene;Hormones;Human;Hypoxia;hypoxia inducible factor 1;in vitro Assay;Incidence;Individual;Inflammation;inhibitor;Knowledge;Liver;Measurement;Measures;Mediating;Methods;Molecular;Morbid Obesity;mouse model;Mus;Myocardial Infarction;novel therapeutics;Nucleotides;Obese Mice;obese person;Obesity;Oral Contraceptives;overexpression;Plasma;Plasma Proteins;Polycythemia;Population;Predisposition;Pregnant Women;Premenopause;Progesterone;Progestins;promoter;protein expression;Protein S;Protein S Deficiency;Proteins;Regulation;Reporting;Repression;response;Risk;RNA;Role;Sampling;side effect;Site;Stroke;Supplementation;synergism;Testing;Thrombin;Thrombophilia;Thrombosis;thrombotic;thrombotic complications;Thrombus;Time;tool;transcription factor;Venous Thrombosis;Woman

PROJECT_TITLE: A Mechanistic Study to elucidate the role of Protein S in elevating the risk of Thrombosis in Obese, Pre-menopausal women

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Nutrition;Physical Activity;Prevention

ORG_CITY: KANSAS CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE There is evidence that exercise is beneficial to the brain in aging and Alzheimer’s Disease (AD), but findings are mixed and the mechanisms that underlie this benefit are unknown. The heterogeneity of benefit may be explained in part by individual differences in the acute biomarker response to exercise, which is the repeated acute and transient changes that occur during and immediately following exercise. The acute biomarker response and its relationship to relevant brain outcomes has not been characterized in elderly or AD individuals. Understanding these relationships will help us understand peripheral metabolites affect the brain and aid in the design of future exercise intervention trials.

PI_NAMEs: MORRIS, JILL KATHLEEN (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Acute;Aerobic Exercise;Affect;aged;Aging;Alzheimer's Disease;Appearance;Area Under Curve;Automobile Driving;Biological Markers;Blood;Brain;brain health;brain metabolism;cardiorespiratory fitness;Cerebrum;Characteristics;Chronic;Clinical Trials;Closure by clamp;Cognition;cognitive benefits;cognitive performance;cohort;Complex;design;Diagnosis;Diagnostic;Disease;Drops;Elderly;Energy Metabolism;executive function;Exercise;exercise intensity;exercise intervention;exercise prescription;exercise program;exercise regimen;Experimental Designs;Fasting;Future;Glucose;glucose metabolism;Goals;Heart Rate;Heterogeneity;Hour;improved;Individual;Individual Differences;Infusion procedures;insight;Intervention;Intervention Studies;Intervention Trial;Ketones;Mediating;Memory;Metabolic;Metabolism;Neuroglia;Neurons;non-demented;Outcome;Outcome Measure;oxidation;Participant;Penetration;Peripheral;peripheral blood;Permeability;Physical activity;Physical Exercise;Physiological;Population;Positioning Attribute;post intervention;prevent;Procedures;Production;response;response biomarker;Rest;Signal Pathway;stable isotope;Time;trial design;uptake

PROJECT_TITLE: Acute exercise and the cerebral metabolic response in aging and Alzheimer's Disease


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Pediatric

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative This project will continue and expand the collection of data on young adults in families participating in the Panel Study of Income Dynamics (PSID) by conducting two waves of the PSID Transition into Adulthood Supplement (TAS) in 2021 and 2023 and by documenting and distributing these data. The TAS data are vital for enhancing our understanding of the contemporary transition from childhood and adolescence into adulthood in the U.S. within its intergenerational family context.

PI_NAMEs: SASTRY, NARAYAN  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: 18 year old;Adolescence;Adoption;Adult;Age;age group;aged;Birth;Child;Child Development;Childhood;cohort;Collection;Computer Assisted;Data;data centers;Data Collection;Data Reporting;design;Development;distributed data;Economics;Eligibility Determination;emerging adult;Enrollment;Family;Family dynamics;Health;higher education;Home;Household;Individual;insight;Institutionalization;instrument;intergenerational;Internet;Interview;Life;Life Cycle Stages;Living Arrangement;Longitudinal Surveys;Measurement;member;Nursery Schools;panel study of income dynamics;Parents;Participant;Patient Self-Report;Period Analysis;Persons;Primary Schools;Process;Resources;Respondent;Rest;Sampling;Secondary Schools;social;social science research;Social Well-Being;Teenagers;Telephone Interviews;Time;transition to adulthood;Work;young adult;Youth

PROJECT_TITLE: The Transition from Childhood into Adulthood among PSID Children, 2021 and 2023

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Genetics;Women's Health Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE One of the most pressing problems in breast cancer treatment is to devise new therapies for estrogen receptor-expressing tumors that do not respond adequately to anti-estrogen therapies. For these tumors, our laboratory discovered that a related hormone receptor, the glucocorticoid or stress hormone receptor, can also be targeted to help reduce tumor growth driven by estrogen. In this project we will perform experiments to understand the mechanisms whereby these two hormone receptors act in breast cancer, with the overall goal of developing new, effective and relatively non-toxic treatments for breast cancer.

PI_NAMEs: CONZEN, SUZANNE DANIELA (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Affect;Agonist;Alpha Cell;Anti-estrogen Therapy;Automobile Driving;Binding;Biological Assay;Breast;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Treatment;Cancer Etiology;Cell Cycle;Cell Line;Cell Proliferation;Cells;ChIP-seq;Chromatin;Chromatin Modeling;chromatin remodeling;Clinical;Clinical Trials;Co-Immunoprecipitations;Complex;Data;Dexamethasone;Differentiated Gene;Duct (organ) structure;Endometrial;Enhancers;ESR1 gene;Estrogen Antagonists;Estrogen decline;Estrogen Receptors;Estrogens;experimental study;follow-up;Gene Expression;Genes;Genetic Transcription;Glucocorticoid Receptor;Glucocorticoids;Goals;Hormone Receptor;Hormones;improved;in vivo;Individual;Laboratories;Ligand Binding Domain;Ligands;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mass Spectrum Analysis;MCF7 cell;Mediating;Metabolic;Metabolic Diseases;Modeling;Molecular;Molecular Conformation;mRNA Expression;Mus;mutant;neoplastic cell;novel;novel therapeutics;Nucleic Acid Regulatory Sequences;Oral;Outcome;Patient-derived xenograft models of breast cancer;Patients;Pattern;Phenotype;Primary Neoplasm;Prognosis;prognostic;Proliferating;Proteins;receptor;Receptor Activation;Receptor Cross-Talk;receptor expression;Receptor Inhibition;Recurrence;Refractory;Regulation;relapse risk;Resistance;response;RNA interference screen;side effect;Stress;T47D;Tamoxifen;targeted treatment;Testing;Time;transcriptome;tumor;tumor growth;Variant;whole genome;Xenograft procedure

PROJECT_TITLE: Estrogen and glucocorticoid receptor crosstalk in ER+ breast


NIH_SPENDING_CATS: Lung

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative This work will define new requirements for classical dendritic cell type-2 (cDC2) positioning, homeostasis and function in spleen and lung. The work will establish the role of the CD97 adhesion-G-protein coupled receptor pathway in splenic cDC2s using flow cytometric, cell signaling and imaging approaches. Studies in EBI2 conditional knockout mice and mice unable to make oxysterols that function as EBI2 ligands will determine how this chemoattractant system determines lung cDC2 distribution and function.

PI_NAMEs: CYSTER, JASON G (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: adaptive immune response;Adhesions;Allergic;Allergic Disease;allergic response;Antibody Response;Antigen Presentation;Antigen-Presenting Cells;Antigens;B-Lymphocytes;Behavior;Blood;blood filter;CD97 gene;cell motility;cell type;Cells;cellular imaging;Chemotactic Factors;conditional knockout;Couples;CRISPR/Cas technology;Critical Pathways;Cues;Dendritic Cells;enzyme deficiency;Epithelium;Erythrocytes;Family member;fMet-Leu-Phe receptor;G-Protein-Coupled Receptors;Generations;Grant;Helper-Inducer T-Lymphocyte;Heterotrimeric GTP-Binding Proteins;Homeostasis;Image;imaging approach;Immune response;immune system function;in vivo;Knockout Mice;Ligands;Location;Lung;Lung Diseases;Lung immune response;Lymphocyte;Lymphoid Tissue;Maintenance;mechanotransduction;Mediating;migration;Molecular;Mus;mutant;novel;Organ;pathogen;pathogen exposure;Pathway interactions;Positioning Attribute;receptor;Reporter;response;Role;screening;secondary lymphoid organ;Sentinel;shear stress;Signal Pathway;Signal Transduction;Site;Source;Spleen;Surface;System;T-Lymphocyte;Th2 Cells;Therapeutic;Tissues;transcription factor;two photon microscopy;Work

PROJECT_TITLE: B lymphocyte Migration and Homeostasis

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Cardiovascular;Hematology

PHR: PROJECT NARRATIVE The proteolytic cleavage of ultra-large von Willebrand factor by ADAMTS13 is crucial for normal hemostasis. However, the mechanism underlying the regulation of this process remains to be poorly understood. The proposed study aims to determine the mechanical unfolding profile of VWF-A2 in the absence and presence of coagulation factor VIII, to elucidate the molecular mechanism of direct interactions between VWF-A2 and factor VIII, and to assess the physiological relevance of factor VIII-dependent regulation of VWF proteolysis by ADAMTS13 under a mechanic force and pathophysiological conditions.

PI_NAMEs: ZHANG, XIAOHUI ;ZHENG, X. LONG  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Acquired von Willebrand disease;ADAMTS;Adhesives;Affect;analytical tool;Animal Model;Aortic Valve Stenosis;Atomic Force Microscopy;beta pleated sheet;Binding;Binding Sites;Biochemical;Biological Assay;biophysical tools;Blood Platelets;Blood Vessels;cleavage factor;cofactor;Complex;design;Deuterium;Development;Disease;Disintegrins;Endothelial Cells;Enzyme-Linked Immunosorbent Assay;Enzymes;Event;Exogenous Factors;Exposure to;Extracorporeal Membrane Oxygenation;Factor VIII;Fibrin;Hemorrhage;Hemostatic function;Human;Hydrogen;in vivo;Individual;Inflammatory;Ischemia;Ischemic Stroke;Laboratories;laser tweezer;Life;Mammalian Cell;Mass Spectrum Analysis;mechanical force;Mechanics;Megakaryocytes;member;Metalloproteases;Molecular;Molecular Conformation;molecular modeling;mutant;Mutant Strains Mice;Myocardial Infarction;novel;novel therapeutics;optic tweezer;Patients;Peptides;Physiological;Plasma;Plasma Proteins;Play;Prevention;Process;Proteins;Proteolysis;Protomer;recombinant antihemophilic factor VIII;Recombinants;Regulation;Risk;Role;Sampling;Series;single molecule;Site;skills;Structural Models;Structure;Surface Plasmon Resonance;System;Techniques;Testing;Thrombocytopenic Purpura;thrombogenesis;Thrombosis;Thrombospondins;thrombotic;Thrombotic Thrombocytopenic Purpura;Tissues;Traumatic Brain Injury;Variant;von Willebrand Disease;von Willebrand Factor

PROJECT_TITLE: Mechanism underlying cofactor-dependent proteolysis of von Willebrand Factor

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Narrative While the degeneration of basal forebrain cholinergic neurons (BFCNs) is a well-known feature of Alzheimer’s Disease, the pattern of degeneration and the extent to which this phenomenon contributes to cognitive decline remain elusive. The research proposed here seeks to define how the neural circuitry associated with BFCNs is altered throughout Alzheimer’s Disease progression and aims to evaluate the effects of targeted, cell-type specific manipulations of BFCNs. Studies such as this are essential to further our understanding of the circuit pathology underlying Alzheimer’s Disease and identify potential therapeutic targets.

PI_NAMEs: BELFORT, BENJAMIN  (contact)

PROJECT_TERMS: Acceleration;Acetylcholine;Acetylcholinesterase Inhibitors;Affect;Age Months;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Attention;awake;basal forebrain;basal forebrain cholinergic neurons;Behavioral;Behavioral Assay;behavioral outcome;Biological Assay;Brain;brain cell;Brain Mapping;Cell Physiology;cell type;Cells;cellular targeting;cholinergic;cholinergic neuron;Cholinesterase Inhibitors;Cognition;Cognitive deficits;cognitive function;Control Groups;Data;data modeling;Decision Making;Dementia;Disease;disease phenotype;Disease Progression;effective intervention;Exhibits;experimental study;extracellular;Functional Magnetic Resonance Imaging;genetic manipulation;Goals;healthy aging;Human;hyperphosphorylated tau;Image;imaging modality;Impaired cognition;improved;in vivo;insight;Investigation;Magnetic Resonance Imaging;Maps;Measures;Mediating;Memory;Molecular;Molecular Analysis;Molecular Profiling;mouse model;Mus;Mutation;Nerve Degeneration;neural circuit;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurofibrillary Tangles;neuronal circuitry;Neurons;neurotransmission;optogenetics;Pathogenesis;Pathologic;Pathology;Pattern;Persons;Pharmacologic Substance;Pharmacotherapy;Physiological;prevent;Research;Role;Senile Plaques;Signal Transduction;Source;Specificity;symptomatic improvement;symptomatology;Symptoms;Therapeutic;therapeutic target;timeline;Tissues;transcriptome;transcriptomics;Transgenic Mice;translating ribosome affinity purification and RNA-sequencing;United States

PROJECT_TITLE: Uncharted Territory: Mapping and Manipulating Cholinergic Basal Forebrain Activity in a Mouse Model of Alzheimer's Disease


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Liver cancer is now a leading cause of cancer-related mortality in the world and the incidences are rising rapidly in this country. However, how various liver injuries and disorders can aggravate tumorigenesis is poorly understood. Success of this project will contribute to better understanding of the carcinogenic liver damages and will provide novel therapeutic strategies for this malignant disease.

PI_NAMEs: FENG, GEN-SHENG  (contact)

PROJECT_TERMS: Acceleration;Address;Animals;Automobile Driving;beta catenin;Cancer Etiology;Carcinogenesis Mechanism;carcinogenicity;Cells;chemical carcinogen;Clinical Treatment;Complement;Country;Data;Defect;design;Development;Diethylnitrosamine;Disease;Drug Targeting;Environmental Risk Factor;Event;Excision;experimental study;Gene Mutation;Goals;Hepatocarcinogenesis;Hepatocyte;Human;Incidence;Inflammatory Response;Knock-out;Liver;liver cancer model;liver cancer patient;liver cell proliferation;Liver diseases;liver injury;Malignant - descriptor;Malignant neoplasm of liver;Modeling;Molecular;Molecular Analysis;mortality;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;NFKB Signaling Pathway;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Oncoproteins;Outcome;Pathogenicity;Pathway interactions;Patients;premalignant;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Process;Recurrence;Reporting;Role;Signal Transduction;Signaling Molecule;success;Testing;theories;Therapeutic;therapeutically effective;Time;tumor;tumor initiation;tumor progression;Tumor Promotion;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Tumor-promoting liver injuries and mechanisms

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Headaches;Migraine;Neurosciences;Opioids;Pain Research

PHR: Project Narrative This renewal application will expand the investigation and modulation of µ-opioid neurotransmission to more complex migraine patients, by identifying how such dysfunction impacts other brain neurotransmitters (dopamine) and systems (sensory/limbic) in chronic migraine leading to increased pain and emotional suffering.

PI_NAMEs: DASILVA, ALEXANDRE  (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Absence of pain sensation;Acute;Affinity;allodynia;Amygdaloid structure;Analgesics;associated symptom;Basal Ganglia;beta-Endorphin;Bilateral;Binding;Brain;Cancer Patient;carfentanil;central pain;Chronic;Clinic;Clinical;clinical application;comorbidity;Complex;conventional therapy;Data;Disease;Dopamine;Dopaminergic Agents;Electrodes;emotion regulation;Emotional;Enkephalins;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Headache;High Prevalence;high risk;Home;improved;in vivo;Intake;Investigation;Life;Limbic System;Link;Measures;Medical;Methods;Migraine;Molecular;Motor Cortex;mu opioid receptors;neuroimaging;Neurons;neuroregulation;neurotransmission;Neurotransmitters;novel;Opioid;Opioid Peptide;Pain;pain perception;pain relief;Parkinson Disease;Pathway interactions;Patients;Peptides;Persistent pain;Pharmaceutical Preparations;Positron-Emission Tomography;Protocols documentation;psychotic;Raclopride;radiotracer;Recording of previous events;Recurrence;Research;resilience;Restless Legs Syndrome;Rewards;Sensory;sensory system;Severities;sex as a biological variable;side effect;Signal Transduction;Solid;somatosensory;Structure;Substance abuse problem;Symptoms;System;Thalamic structure;transcranial direct current stimulation;Trigeminal System;uptake

PROJECT_TITLE: Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in vivo)

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Project Narrative: Despite enormous recent progress in treatment and supportive therapies for acute myeloid leukemia (AML), it accounts for the highest percentage of leukemic deaths, and less than a third of patients will become long-term survivors. We recently discovered that specific AML-associated mutations in two genes, isocitrate dehydrogenase-1 and -2 (IDH1/2), block DNA repair pathways and lead to sensitivity to drugs which block these same pathways. Here, we seek to develop highly effective combinations against AMLs with IDH1/2 mutations, as well as mutations in other AML-related genes.

PI_NAMEs: BINDRA, RANJIT  (contact);HALENE, STEPHANIE

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acute Myelocytic Leukemia;alpha ketoglutarate;Binding;Cessation of life;chemotherapy;Citric Acid Cycle;Clinic;Clinical Trials;Collection;Combined Modality Therapy;cytokine;Cytostatics;Data;Defect;Dioxygenases;DNA;DNA Damage;DNA Double Strand Break;DNA Repair Pathway;DNMT3a;Double Strand Break Repair;drug action;efficacy testing;Engineering;enzyme activity;Enzymes;Epigenetic Process;Event;FDA approved;FLT3 gene;Gene Mutation;Genes;hematopoietic differentiation;Heterozygote;Histones;homologous recombination;Hypermethylation;immunodeficiency;Impairment;In complete remission;In Vitro;in vivo;in vivo Model;Induced Mutation;inhibitor;insight;Isocitrate Dehydrogenase;Isocitrates;leukemia;leukemogenesis;Long-Term Survivors;Lysine;Malignant Neoplasms;Metabolic;Methylation;Mitogen-Activated Protein Kinases;Modeling;molecular subtypes;Mus;mutant;Mutation;Newly Diagnosed;novel therapeutic intervention;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Production;Protein Isoforms;Relapse;Reporting;Resistance;resistance mechanism;response;restoration;Signal Pathway;Signal Transduction;Site;Specimen;SRSF2 gene;Supportive care;synthetic lethal interaction;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Toxic effect;Translating;Treatment Efficacy;Tricarboxylic Acids;tumor;Work;Xenograft Model

PROJECT_TITLE: Targeting Defective DNA Damage Response Pathways in IDH1/2-mutant AML


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: PITTSBURGH

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE: The skin functions as a potent immune organ, rendering the readily accessible cutaneous microenvironment an attractive target that can be locally engineered to induce and regulate systemic immune responses. Increasing age is associated with changes in immune function (immunosenescence) that result in increased susceptibility to diseases and poor vaccine responses in older adults. This proposal is designed to bring together very recent and significant advances in dermatology and skin biology to address critical problems in human health. Specifically, we propose to modulate local immune regulatory circuits in the skin to enable the induction and regulation of antigen-specific systemic immune responses. The studies we propose will investigate the effect of locally delivered immune modulators on the mechanisms underlying cutaneous immune regulation in young and aged skin. Importantly, our studies include translational studies using living human skin to enable the rapid advancement of novel cutaneous immunomodulation strategies into clinical trials. An improved understanding of these underlying skin immune mechanisms will enable the development of localized skin targeted immunization strategies to induce antigen-specific systemic immune responses for the prevention or treatment of a broad range of diseases across the lifespan.

PI_NAMEs: FALO, LOUIS D (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Address;Adjuvant;Age;age related changes;aged;Antibodies;Antibody Response;Antigen-Presenting Cells;Antigens;Biology;biomarker identification;Bronchoalveolar Lavage;CD8-Positive T-Lymphocytes;Cell Physiology;Cellular Immunity;Clinical;clinical application;clinical translation;Clinical Trials;Combined Vaccines;COVID-19;COVID-19 vaccine;Cutaneous;Data;Dermatology;design;Development;Disease;Dose;draining lymph node;Engineered skin;Engineering;experience;Funding;Generations;Goals;Health;Human;Immune;immune function;Immune response;Immune system;Immunity;Immunization;Immunobiology;immunoengineering;immunogenicity;Immunologics;Immunomodulators;immunoregulation;immunosenescence;improved;In Situ;Inflammatory;Injections;innate immune mechanisms;Innate Immune Response;Learning;life span;Lung;Lymphoid Tissue;Methods;Natural Immunity;Needles;neutralizing antibody;next generation;novel;old mice;older adult;Organ;pathogen;peripheral blood;Phase I/II Clinical Trial;Predisposition;Prevention;Protein Subunits;Publishing;rational design;Regulation;Reproducibility;Safety;SARS-CoV-2 antigen;SARS-CoV-2 immunity;Skin;Skin Aging;Skin Cancer;Spleen;Subunit Vaccines;T-Lymphocyte;targeted delivery;technology platform;translational study;Translations;United States National Institutes of Health;Vaccination;vaccination strategy;vaccine delivery;vaccine development;vaccine efficacy;vaccine response;Vaccines

PROJECT_TITLE: Engineering the Skin Immune System to Induce Systemic Immune Responses

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE New therapeutic strategies are needed to treat acute myeloid leukemia, the most common form of leukemia in the United States. This research project will identify and characterize new small molecules that have the potential to become drugs to treat this disease.

PI_NAMEs: BACHOVCHIN, DANIEL  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Active Sites;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Amino Acids;analog;Binding;cancer cell;Cancer cell line;CASP1 gene;Cell Death;cell type;Cells;Chemicals;Communities;cytokine;cytokine release syndrome;Data;design;Diagnosis;Dipeptidases;Dipeptides;Disease;efficacy evaluation;Enzyme Inhibitor Drugs;Enzymes;Hematopoietic;Human;Immune system;improved;in vivo;Inflammasome;Inflammatory;inhibitor;Laboratories;Lead;lead candidate;leukemia;Leukemic Cell;Lytic;Malignant Neoplasms;Molecular;mouse model;multicatalytic endopeptidase complex;Multiprotein Complexes;Mus;N-terminal;Normal Cell;novel therapeutic intervention;novel therapeutics;Patients;Peptides;Pharmaceutical Preparations;pharmacologic;pre-clinical;Proliferating;Proline;Proteins;Recycling;Research;Research Project Grants;response;Sampling;Serine;Serine Protease;Serine Proteinase Inhibitors;Signal Induction;Signal Transduction;small molecule;small molecule inhibitor;Specificity;Survival Rate;Testing;Therapeutic;Therapeutic Agents;Tissues;tool;Toxic effect;United States;Work;Xaa-Pro dipeptidase

PROJECT_TITLE: Prolidase Inhibitors as Therapeutic Agents for Acute Myeloid Leukemia

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Opioids are commonly prescribed medications for a variety of pain conditions; however, these medications carry significant risks due to their addictive potential and lethality via respiratory depression. The mechanisms underlying opioids’ beneficial and harmful effects are still unknown and few successful treatments for pain have been created since opioid use became widespread. This proposal aims to characterize the effects of opioids on prefrontal cortex output neurons and to dissociate the prefrontal cortex circuits that underlie opioid analgesia and addiction to allow for more precise targeting of future therapeutics.

PI_NAMEs: OCHANDARENA, NICOLE ELISE (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Absence of pain sensation;Academic Medical Centers;Acute;addiction;Affect;Analgesics;Area;Behavior;Biological Assay;Brain;Calcium;cell type;Cells;Chronic;Color;Complex;conditioned place preference;Corpus striatum structure;Data;Dissociation;Doctor of Philosophy;Drug Prescriptions;Electrophysiology (science);Environment;experimental study;Future;Genetic;Genetic Suppression;Glutamates;Goals;hippocampal pyramidal neuron;Histology;Hyperalgesia;Image;imaging approach;Implantable Pump;innovation;Interneurons;Knowledge;Mechanics;Medial;Mediating;Medicine;Modeling;Morphine;Motivation;mouse model;mu opioid receptors;Mus;Naloxone;Nervous System;neural;neural circuit;Neuroanatomy;Neurons;North Carolina;Opiate Addiction;Opioid;Opioid Analgesics;opioid epidemic;opioid exposure;opioid use;Oral;Output;oxycodone self-administration;Pain;pain behavior;Pain management;pain relief;Pattern;Pharmaceutical Preparations;Physicians;Population;Postoperative Pain;Prefrontal Cortex;programs;Property;Proxy;Pyramidal Tracts;receptor expression;receptor function;Receptor Signaling;Relapse;Reporter;Research;Research Proposals;reward circuitry;Rewards;Risk;Role;Scientist;Signal Transduction;single-cell RNA sequencing;skills;subcutaneous;Testing;Therapeutic;Tissues;Training;United States;Universities;Ventilatory Depression;Withdrawal

PROJECT_TITLE: Circuit mechanisms for opioid analgesia and addiction in prefrontal cortex


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;Health Services;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

PHR: Adolescent relationship victimization (ARV), including physical, sexual, cyber or psychological abuse, reproductive coercion, and sexual exploitation, is a public health problem with broad, lifelong negative outcomes that result in significant cost to both individuals and society. The emergency department (ED) offers unique opportunities to promote healthy relationships among large numbers of at-risk youth, but current interventions are limited by disclosure-based delivery, limited efficacy, addressing limited forms of abuse, and missed opportunities to provide point-of-care harm reduction resources. Our proposal to adapt the Healthcare Education Assessment and Response for Teen Relationships (HEART) intervention for the ED setting will result in a novel intervention that is delivered universally, addresses ARV comprehensively, and links adolescents to point-of-care harm reduction resources to improve health outcomes across multiple domains, contributing to disruption of generational cycles of violence and early childbearing

PI_NAMEs: RANDELL, KIMBERLY ANNE (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Academic achievement;Accident and Emergency department;Address;Adolescent;Age;Behavior;behavior change;Behavior Therapy;Behavioral Research;brief intervention;care seeking;career;career development;clinical practice;Clinical Research;Clinical Trials;community engagement;community setting;comparison control;condoms;Consensus;cost;Counseling;Data;design;Development;Development Plans;Disclosure;Dropout;Drops;early childbearing;Eating Disorders;Education;Educational Assessment;Educational Intervention;effective intervention;efficacy testing;efficacy/implementation trial;Emergency Care;emergency contraception;Emergency Department evaluation;Emergency department visit;Emergency Department-based Intervention;Emergency Medicine;emotional abuse;Evaluation;Evidence based intervention;experience;Feasibility Studies;feasibility trial;Female Adolescents;follow-up;Goals;Harm Reduction;Health;Health Services;Healthcare;Healthy People 2020;High Prevalence;high-risk adolescents;Homicide;Hybrids;implementation science;implementation study;improved;Individual;Intervention;K-Series Research Career Programs;Knowledge;Life Cycle Stages;Link;Male Adolescents;Manuals;Measures;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Mission;Modeling;Modification;motivational enhancement therapy;National Institute of Child Health and Human Development;novel;Outcome;Parents;Participant;patient oriented;Patients;pediatric emergency;Performance;Physicians;point of care;Population;Populations at Risk;Pregnancy;prevent;primary care provider;primary outcome;programs;Provider;Public Health;Randomized, Controlled Trials;Recommendation;Reporting;reproductive coercion;Research;Research Ethics;Resources;response;Risk;Risk Factors;school based health center;Schools;sexual exploitation;Sexual Health;Sexually Transmitted Diseases;skills;Societies;Speed;Structure;suicidal;Teenagers;Testing;theories;Training;Training Activity;Translations;treatment as usual;Treatment Efficacy;trial comparing;United States Dept. of Health and Human Services;United States National Institutes of Health;Victimization;Violence;Work;Youth

PROJECT_TITLE: Promoting Healthy Relationships among At-Risk Adolescents: A Feasibility Trial in the Emergency Department

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Kidney Disease;Lung;Maternal Health;Maternal Morbidity and Mortality;Neonatal Respiratory Distress;Organ Transplantation;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Transplantation;Women's Health Research

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Early onset anhydramnios from fetal renal failure, which affects > 1 in every 2000 pregnancies in the United States per year, leads to pulmonary hypoplasia that is fatal in the neonatal period. This multicenter prospective trial will rigorously test the first ever viable therapy of serial amnioinfusions, to assess short- and long-term safety, feasibility and efficacy to treat this fatal disease. This work will fill critical gaps in knowledge and help optimize the chance that fetuses with early onset anhydramnios are born as healthy as possible with the best chance of long-term survival.

PI_NAMEs: ATKINSON, MEREDITH ANN (contact);MILLER, JENA L

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Abruptio Placentae;Address;Affect;Agreement;American;Amniocentesis;Amniotic Fluid;Amniotic Fluid Embolism;Bilateral;Biological Markers;Birth;Case Study;Child;Childhood;Chronic;Clinical;clinical practice;cohort;congenital anomalies of the kidney;Data;Data Coordinating Center;Decision Making;Diagnosis;Dialysis procedure;Disease;Early Diagnosis;early onset;early pregnancy;Educational workshop;efficacy study;Eligibility Determination;Equipment and supply inventories;Exclusion Criteria;Expectancy;experience;Family;Feasibility Studies;fetal;Fetal Diseases;Fetal Lung;Fetal safety;Fetus;First Pregnancy Trimester;Goals;Growth;Head;health goals;Hemodialysis;Hemorrhage;Hospitals;Impairment;improved;in utero;inclusion criteria;Infant;Infusion procedures;innovation;Institutional Review Boards;Intervention;intraamniotic infection;Kidney;Kidney Failure;Kidney Transplantation;Knowledge;Letters;lipidomics;living kidney donor;Lung;lung development;lung preservation;lung volume;Magnetic Resonance Imaging;Maternal complication;maternal safety;Measurement;Measures;Modeling;Multi-Institutional Clinical Trial;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Neonatal;neonatal period;neonatal respiration;neonate;novel;Outcome;Oxygen;Parents;Patients;Peritoneal Dialysis;pilot trial;post-transplant;postnatal;Pregnancy;Pregnancy Complications;Premature Birth;Premature Labor;Premature Rupture Fetal Membranes;prenatal;prenatal therapy;preterm premature rupture of membranes;prospective;Prospective Studies;Proteomics;Protocols documentation;Publishing;Pulmonary artery structure;pulmonary function;pulmonary hypoplasia;Qualifying;Quality of life;Radiology Specialty;renal agenesis;Renal function;Renal Tissue;Reporting;Respiratory Failure;Respiratory physiology;Safety;safety and feasibility;safety study;Saline;Secondary to;Site;Stress;Survivors;Techniques;Testing;Therapy trial;Toddler;Transplantation;Treatment Efficacy;treatment strategy;ultrasound;United States;Urinary tract;Urine;Uterine Rupture;Women's mortality;Work

PROJECT_TITLE: Renal Anhydramnios Fetal Therapy (RAFT) Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PN-A(07)S]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Diabetes;Genetics;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Rare Diseases;Spina Bifida;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Pregestational diabetes induces neural tube defects (NTDs) in the offspring, one of the most common birth defects in human. Yet, the molecular mechanism underlying the teratogenicity of maternal diabetes is still unclear. This project will unravel the mechanism underlying maternal diabetes-induced autophagy impairment leading to NTDs. The proposed mechanistic studies will provide a basis for the therapeutic development of autophagy activator, unfolded protein response inhibitor and microRNAs as new prevention strategy against diabetic embryopathy.

PI_NAMEs: YANG, PEIXIN  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Age;American;Apoptosis;Autophagocytosis;Autophagosome;Binding;Binding Proteins;Child;Complex;Congenital Abnormality;Data;Diabetes Mellitus;diabetic;diabetic embryopathy;Disabling;Embryo;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;Exposure to;functional restoration;Gene Deletion;Gene Expression;Gene Proteins;Genes;glycemic control;Homeostasis;Human;Hyperglycemia;Impairment;Induction of Apoptosis;inhibition of autophagy;inhibitor;Knockout Mice;Link;malformation;MAP3K5 gene;maternal diabetes;Measures;Mediating;Messenger RNA;MicroRNAs;Molecular;Mothers;Mus;Neural Tube Defects;neuroepithelium;non-diabetic;offspring;Organelles;overexpression;Pathway interactions;Phosphorylation;Play;Pregnancy in Diabetics;Prenatal care;prevent;Prevention strategy;Process;Production;Protein Deficiency;Proteins;Public Health;Regulation;Repression;reproductive;response;Ribonucleases;Role;sensor;Signal Transduction;Stress;Teratogens;Testing;therapeutic development;Transgenic Mice;Transgenic Organisms;TXNIP gene;Up-Regulation;Woman;XBP1 gene;Xenopus

PROJECT_TITLE: Autophagy and its Regulation in Diabetic Embryopathy

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ORG_CITY: FARMINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: PROJECT NARRATIVE Alzheimer’s Disease (AD) is the most common cause of dementia. The physiological functions of beta-secretase- 1 (BACE1), the rate-limiting protease in the formation of AD amyloid plaques, is incompletely known, particularly at the level of the synapse in different neuronal circuits. This project will shed light on BACE1’s function in regulating the activity of excitatory neurons, synapses, and circuits in the hippocampus, which will provide critical insight into our fundamental understanding of learning and memory, synaptic transmission and plasticity, and the development of AD therapeutics.

PI_NAMEs: YAO, ANNIE Y (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: abeta accumulation;abeta oligomer;Address;Adult;Adverse effects;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Amyloid beta-Protein;Behavior;Behavioral;Behavioral Assay;behavioral study;beta-site APP cleaving enzyme 1;Biochemical;Brain;career;Cause of Death;cell type;Cells;Cessation of life;Clinical Skills;Clinical Trials;Cognition;Cognitive deficits;cognitive function;Communication;Data;Defect;Dementia;designer receptors exclusively activated by designer drugs;Development;Development Plans;Disease;Disease Progression;doctoral student;drug development;Electrophysiology (science);Enzymes;epileptiform;Equilibrium;excitatory neuron;Excitatory Synapse;experience;extracellular;Failure;Future;Generations;Genetic;genetic approach;genetic manipulation;Germ Lines;Health;hippocampal pyramidal neuron;Hippocampus;Human;Impaired cognition;Impairment;in vivo;inhibitor;insight;Ion Channel;Knockout Mice;Knowledge;Learning;Membrane;Membrane Potentials;Memory;Memory impairment;Memory Loss;Mentors;Methods;Mus;mutant;Mutant Strains Mice;Neurodegenerative Disorders;neuronal circuitry;neuronal excitability;Neurons;neurophysiology;neurotoxicity;novel;patch clamp;Pathologic;Patients;Peptide Hydrolases;Phase;Phenotype;Physicians;Physiological;Physiology;Play;Potassium;presynaptic;prevent;Property;Prosencephalon;Publishing;Regulation;Research;Rest;Rodent;Rodent Model;Role;Scientist;Seizures;Senile Plaques;skills;Sodium;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Technical Expertise;Techniques;Testing;Therapeutic;therapeutic target;Training;Transgenic Organisms;voltage

PROJECT_TITLE: The role of beta-secretase 1 (BACE1) in modulating excitatory synaptic and circuit function and behavior


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lupus;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE  Childhood-onset systemic lupus (cSLE), a devastating disease with high morbidity and mortality, especially among adolescents and young adults (AYA) of color and low-income, requires engagement in SLE care to prevent poor outcomes. Depression is highly comorbid with cSLE and may contribute to disengagement in care, along with socio-demographic, clinical, and other psychosocial factors. This research will investigate specific depression symptoms as potential contributors to disengagement in AYA with cSLE and pilot a mobile app intervention targeting engagement in care and providing psychological support in a vulnerable population of predominantly low-income, Black and Hispanic AYA from The Bronx, New York.

PI_NAMEs: RUBINSTEIN, TAMAR B (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: acceptability and feasibility;Accounting;Address;Adolescent;Adolescent and Young Adult;Adult;adult of color;Affect;Anhedonia;Anxiety;Attention;Autoimmune Diseases;Award;Behavior;Behavior assessment;behavioral construct;behavioral health intervention;Biometry;biopsychosocial;Black race;black women;Brain;Caliber;career;Caring;Cause of Death;Cessation of life;Child;child depression;Childhood;Chronic;Chronic Disease;Clinical;Clinical Investigator;Clinical Research;cohort;college;Color;community setting;comorbid depression;comorbidity;Data;Department chair;Depressed mood;depressive symptoms;Development;Diagnostic;Disease;Disease Progression;Disparity;Disparity population;Distress;Education;Effectiveness;Ensure;Environment;Etiology;Exhibits;Feasibility Studies;Follow-Up Studies;Future;Goals;Health behavior;health disparity;Healthcare Systems;Heterogeneity;high risk;Hispanic;Hispanic Women;improved;improved outcome;Individual;Individual Differences;Inflammation;Interdisciplinary Study;Intervention;Intervention Studies;Knowledge;longitudinal analysis;Longitudinal cohort;longitudinal design;Low income;Low Income Population;Lupus;Managed Care;Measures;Medical Care Team;Medicine;Mental Depression;Mental disorders;Mentors;Mentorship;Methodology;Methods;minority children;minority communities;Minority Groups;mobile application;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Mental Health;New York;novel;open label;Outcome;Parents;Participant;patient engagement;patient oriented;Patients;Pediatrics;people of color;Peripheral;Phenotype;Pilot Projects;Play;Population;Positioning Attribute;Prevalence;prevent;Primary Care;professor;Psychiatry;psychologic;Psychosocial Factor;recruit;Reporting;Research;Research Design;Research Domain Criteria;Research Ethics;Research Institute;Research Methodology;Resources;response;Rheumatology;Scheme;Severities;skill acquisition;skills;social determinants;social disparities;sociodemographics;Sociology;Strategic Planning;suicidal;Surveys;symptom cluster;Symptoms;Systemic Lupus Erythematosus;Testing;Time;Training;Visit;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Engagement and Depression in Adolescents and Young Adults with Childhood-onset Lupus

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: The goal of Medical Student Research Program in Metabolism, Diabetes, Digestive and Kidney Diseases (MSRP-MDDK) at the University of Utah School of Medicine is to nurture and build the physician-scientist workforce of tomorrow through mentored summer research experiences and an innovative course on creative and critical thinking in the research fields of metabolism, diabetes, digestion, hematologic or kidney disease.

PI_NAMEs: BEDDHU, SRINIVASAN  (contact);ROUND, JUNE LOUISE

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Area;Award;cohort;Communities;Creativeness;Critical Thinking;Development;Diabetes Mellitus;Digestion;Digestive System Disorders;Doctor of Philosophy;experience;Faculty;Funding;Goals;Grant;Health;Health Sciences;Healthcare;Hematological Disease;Idaho;innovation;Institution;interest;Journals;Kidney Diseases;Location;Manuscripts;matriculation;Medical;medical schools;Medical Students;member;Mentors;Metabolism;Montana;National Institute of Diabetes and Digestive and Kidney Diseases;Nevada;Peer Review;Physicians;posters;programs;Publications;Research;Research Training;Scientist;skills;student participation;Students;success;summer research;symposium;Training;Translational Research;Universities;Utah;Wyoming

PROJECT_TITLE: MSRP in Metabolism, Diabetes, Digestive and Kidney Diseases


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Climate-Related Exposures and Conditions;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Social Determinants of Health

PHR: Project Narrative Exposure to ambient air pollutant ozone is associated with several adverse outcomes, including pulmonary diseases. The goal of this grant proposal is to better understand why some people are more adversely affected by ozone exposure than others, and to identify biological mechanisms underlying differences in ozone response.

PI_NAMEs: KELADA, SAMIR  (contact);MOHLKE, KAREN L.

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acute;Address;Adverse effects;adverse outcome;Affect;Air;air filter;Air Pollutants;Air Pollution;airway epithelium;airway inflammation;Alleles;Applications Grants;Asthma;asthmatic;ATAC-seq;Binding;Biological;Biological Models;Black race;bronchial epithelium;Candidate Disease Gene;Cardiopulmonary;causal model;Cell model;cell type;Cells;Cellular biology;chemokine;Chromatin;Complex;CRISPR/Cas technology;cytokine;cytotoxicity;Data;data integration;Data Set;Development;DNA-Binding Proteins;epigenome;epigenomics;Epithelial Cells;epithelial injury;Exhibits;exposed human population;Exposure to;gene environment interaction;Gene Expression;Gene Expression Regulation;gene induction/repression;Genes;Genetic;Genetic Determinism;Genetic Transcription;genetic variant;Genome;Genomics;Genotype;Goals;GSTM1 gene;Human;Human Volunteers;IL8 gene;In Vitro;in vivo;Individual;Individual Differences;Inflammation;Inflammatory;innovation;insight;interest;knock-down;Link;Lipid Peroxidation;Lipid Peroxides;Lipids;Liquid substance;Lung Diseases;Maps;Measures;Mediating;Mediation;Messenger RNA;Modeling;Molecular;Morbidity - disease rate;mortality;MUC5AC gene;Multiomic Data;multiple omics;Natural Immunity;Neutrophil Infiltration;novel;Onset of illness;Oxidative Stress;Ozone;ozone exposure;Participant;Persons;Phenotype;Predisposition;Prevention;Production;Public Health;pulmonary function;Quantitative Trait Loci;Reaction;Reactive Oxygen Species;Regulatory Element;Reporter Genes;Reproducibility;Research Personnel;Respiratory Disease;Respiratory System;response;Rest;Role;Sampling;sex;Single Nucleotide Polymorphism;single-cell RNA sequencing;Specificity;Structure of parenchyma of lung;Testing;Tissue Donors;Toxicology;trait;transcription factor;transcriptome sequencing;Validation;Variant;Work

PROJECT_TITLE: Regulatory Genomics of Ozone Air Pollution Response in Vitro and In Vivo

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE Despite the accelerating expansion of online resources for modern life science education and training, the reality is that development of molecular biology laboratory-based skills requires `hands-on' instruction, preferably in a research-oriented context. Educational strategies that rely on lecture alone or traditional, but outdated, laboratory experiences ineffectively prepare the current and future generations of the US biomedical workforce. New paradigms are needed for molecular biology lab training that are flexible, inclusive, broadly applicable and supportive of inter-institutional cooperation, all of which is addressed in the proposed project.

PI_NAMEs: GOLLER, CARLOS C;KELLY, ROBERT M (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Acceleration;Address;Adoption;Bioethics;Biological Sciences;Biology;Biotechnology;career development;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;college;Communication;Communities;community college;Creativeness;design;Development;disabled students;Economics;Education;education resources;Educational process of instructing;Educational workshop;Elements;Epigenetic Process;Equipment;evidence base;experience;Face;Faculty;flexibility;Fostering;Foundations;Future Generations;Goals;graduate student;hands on instruction;higher education;innovation;Institution;instructor;inter-institutional;Interdisciplinary Study;Laboratories;laboratory curriculum;laboratory experience;laboratory module;Learning Module;lectures;member;Mentors;Metagenomics;Methods;mid-career faculty;minority student;Mission;Modernization;Molecular;Molecular Biology;North Carolina;novel;online resource;outreach;Participant;pedagogical content;Postdoctoral Fellow;Process;Productivity;programs;Protocols documentation;Reagent;Research;RNA Interference;skills;student training;Students;support network;System;teacher;teaching assistant;Technology;Training;Training and Education;Training Programs;undergraduate student;United States National Institutes of Health;Universities;virtual

PROJECT_TITLE: Molecular Biotechnology Laboratory Education Modules (MBLEM)