NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Pediatric;Rare Diseases;Sickle Cell Disease

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE A small number of adult red blood cells are able to express fetal hemoglobin; increasing the number of these cells is an important approach to the treatment of sickle cell disease. This project proposes to analyze the cells that are able to activate fetal hemoglobin and to study potential factors involved in control of fetal hemoglobin in healthy individuals, those with sickle cell disease, and following treatment with specific medications. Results from this study will provide new potential approaches for the treatment of sickle cell disease.

PI_NAMEs: KHANDROS, EUGENE  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Address;Adult;Advisory Committees;ATAC-seq;Attenuated;Award;Benign;beta Globin;Bioinformatics;Biological Assay;Biology;career;career development;Cell Line;cell type;Cells;Cellular biology;Characteristics;CHD7 gene;Chromatin;Chromatin Loop;chromatin remodeling;chromosome conformation capture;Clinical;clinically relevant;CRISPR/Cas technology;Data;Development;Development Plans;Disease;Distal;Doctor of Philosophy;Enhancers;Environment;enzyme activity;Enzymes;Epigenetic Process;Erythroblasts;Erythrocytes;Erythroid;Erythroid Cells;Erythropoiesis;Exhibits;experience;experimental study;fetal;Fetal Hemoglobin;Fluorescent in Situ Hybridization;Funding;Future;Gene Expression Regulation;Genes;Genetic;Genetic Screening;Genetic Transcription;Genetic Variation;Globin;Goals;Hematology;Hemoglobin;Hemoglobinopathies;Heterogeneity;Human;hydroxyurea;Individual;instructor;International;Kinetics;Locus Control Region;loss of function;Maps;Mentors;Molecular;Molecular Biology;novel;Nuclear;Nucleosomes;overexpression;Pathway interactions;Patients;Pattern;Pediatric Hematologist;Pediatric Hospitals;Pediatrics;Pennsylvania;Pharmaceutical Preparations;pharmacologic;Philadelphia;Physicians;Physiological;pomalidomide;Population;Positioning Attribute;Production;promoter;Proteome;Regulation;Research;research and development;Research Personnel;Resources;response;RNA;Role;Scientist;Severities;Sickle Cell Anemia;Sickle Cell Trait;sickling;single molecule;Site;skills;SMARCA4 gene;SMARCA5 gene;Sorting;Source;Stimulus;Techniques;Thalassemia;Therapeutic;therapeutically effective;Training;Transcript;transcription factor;transcriptome;Transposase;Universities;Variant

PROJECT_TITLE: Regulation of hemoglobin production in normal and disease states

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: SHREVEPORT

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: Project Narrative Despite significant gains in colorectal cancer (CRC) screening promotion, disparities persist among low-income individuals, those with fewer years of education, racial/ethnic minorities, and rural populations. Residents of rural areas suffer significant health inequities and encounter barriers to CRC screening which are often overlooked in healthcare research. This project seeks to address these disparities with a health literacy, shared decision making strategy coupled with tailored ‘stepped care’ automated telephone outreach (recorded by the patient’s primary care provider) that promotes long-term adherence to CRC screening in resource-limited, rural health centers via colonoscopy or annual fecal immunochemical test (FIT).

PI_NAMEs: ARNOLD, CONNIE L. (contact)

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: 2 arm randomized control trial;Address;adenoma;Adherence;Adult;American Cancer Society;arm;Cancer Intervention;Caring;Clinical;Collaborations;colon cancer patients;Colonoscopy;Colorectal Cancer;colorectal cancer screening;Cost Analysis;Counseling;Coupled;Data;Decision Making;design;Detection;Disparity;Education;effectiveness study;effectiveness testing;ethnic diversity;Ethnic Origin;Ethnic Population;evidence base;Evidence based practice;Federally Qualified Health Center;follow-up;Funding;gender disparity;Guidelines;Health;Health Care Research;health disparity;health inequalities;health literacy;Health Personnel;Health Sciences;Healthcare Systems;implementation barriers;improved;Instruction;Intervention;Knowledge;Learning;literacy;literate;Literature;Louisiana;Low income;Low Income Population;Medicaid;Methods;Minority Groups;Motivation;National Cancer Institute;novel;outreach;patient oriented;patient population;Patient Preferences;Patients;personalized approach;point of care;Preparation;primary care patient;primary care provider;primary outcome;Printing;Provider;Race;racial disparity;racial diversity;racial minority;Research;Resources;Rural;rural area;Rural Community;rural dwellers;Rural Health;Rural Health Centers;rural health clinic;rural patients;Rural Population;Schedule;screening;screening disparities;Screening for cancer;screening guidelines;Services;sex;shared decision making;Site;Socioeconomic Status;Standardization;Technology;Telephone;Testing;Text;Text Messaging;treatment as usual;Universities;usual care arm

PROJECT_TITLE: Patient-Centered Reminders to Inform, Motivate, and Engage Colorectal Cancer Screening Adherence in Rural Communities: The PRIME-CRC Trial

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Funding is requested to renew a training program to mentor 4 predoctoral and 4 postdoctoral fellows who represent the next generation of researchers in public health and data science on the prevention of HIV and related syndemics (e.g. viral hepatitis, TB, STIs, SARS-CoV-2, overdose, stigma, trauma) among substance using populations. Our active research programs in nearby Mexico and 23 other countries create the opportunity for unique, hands-on international training experiences and an infrastructure for trainees to develop into independent investigators.

PI_NAMEs: MARTIN, NATASHA  (contact);STRATHDEE, STEFFANIE A.

PROGRAM_OFFICER_NAME: LOPEZ, MARSHA

PROJECT_TITLE: Training Program in Substance Use, HIV and Related Infections


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE A growing epidemic of stimulant use among sexual minority men (SMM), including those living with HIV, could interfere with achievement of the U.S. Ending the HIV Epidemic goals, with improved HIV virologic suppression among SMM who use stimulants needed. This project will first examine multi-level determinants of HIV virologic suppression including stimulant use in a digitally recruited cohort of SMM. We will then perform a randomized controlled trial of reSTART, a multi-component HIV antiretroviral therapy adherence intervention that integrates a point-of-care urine test for HIV adherence self-monitoring and an evidence-based positive affect intervention for SMM living with HIV who use stimulants, to examine reSTART’s impact on virologic suppression, adherence, stimulant use, positive affect/emotions of participants, and cost.

PI_NAMEs: CARRICO, ADAM WAYNE;GANDHI, MONICA ;SPINELLI, MATTHEW A. (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: 2 arm randomized control trial;2019-nCoV;Achievement;Address;Adherence;Affect;African American;antiretroviral therapy;Behavior Therapy;Black race;Caring;Clinical Research;Cocaine;cohort;cost;Counseling;Crack Cocaine;Data;digital;Drug Monitoring;efficacy testing;Emotions;Enrollment;Epidemic;evidence base;experience;Feedback;Goals;Hair;health care service utilization;HIV;HIV anti-retroviral;home test;Human immunodeficiency virus test;improved;incremental cost;Individual;Intervention;intervention effect;Maintenance;Measures;men;men who have sex with men;Methamphetamine;mhealth interventions;microcosting;Mobile Health Application;Modeling;Monitor;Moods;Motivation;multi-component intervention;Namibia;Nature;novel;Outcome;Participant;Patient Recruitments;Patient Self-Report;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;point of care;point of care testing;Population;Prevalence;primary outcome;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Research;resilience;response;Sampling;secondary outcome;Self Administration;sexual minority men;Site;smartphone application;social;Social Network;social stigma;standard of care;Stimulant;stimulant use;structural determinants;Structural Racism;Subgroup;Surveys;Techniques;Tenofovir;Test Result;Testing;Therapeutic;therapy adherence;Time;tool;treatment adherence;Underserved Population;Urine;Venous blood sampling;Viremia;Visit;Work

PROJECT_TITLE: Developing a U.S. National Cohort to Improve Virologic Suppression among Stimulant-using Men Living with HIV.


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Liver Disease;Radiation Oncology;Skin Cancer

ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Rational combinatorial approaches are urgently needed to enhance immune checkpoint inhibitor efficacy in patients with liver metastases. We have discovered that liver metastases siphon and delete tumor-specific T cells to cause systemic immunotherapy resistance, and moreover that ablative liver-directed radiotherapy can restore immune checkpoint inhibitor efficacy. Herein we propose to evaluate mechanisms of immunotherapy resistance in melanoma patients and preclinical melanoma models with liver metastases as well as mechanistically define how liver SBRT overcomes immunotherapy resistance.

PI_NAMEs: LAWRENCE, THEODORE S (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: adaptive immunity;Address;Adenosine;Adoptive Transfer;Antigens;Apoptosis;Biological Markers;biomarker development;Caring;CD8-Positive T-Lymphocytes;Cell Count;Cell Survival;Cells;Circulation;Clinical;Clinical Trials;Colorectal;combinatorial;Combined Modality Therapy;Companions;Data;Disease;effector T cell;Evaluation;Flow Cytometry;Goals;Hepatic;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immune System Diseases;Immune Tolerance;Immunologics;immunomodulatory therapies;Immunosuppression;Immunotherapy;improved;insight;intrahepatic;ipilimumab;irradiation;Knock-out;Liver;liver ablation;liver biopsy;lymph nodes;Macrophage;Measures;Melanoma;Melanoma patient;Metabolic;metabolomics;Metastasis Induction;Metastatic Melanoma;Metastatic Neoplasm to the Liver;Modeling;mouse model;Myelogenous;new therapeutic target;Nivolumab;novel;overexpression;participant enrollment;Pathway interactions;Patient Care;patient population;Patients;Peripheral;peripheral blood;Pharmacogenomics;pre-clinical;Pre-Clinical Model;Preclinical Testing;Production;prospective test;Publishing;purine metabolism;Purines;Radiation therapy;randomized trial;Research Personnel;Resistance;response;response biomarker;Role;Safety;Signal Transduction;single cell sequencing;single-cell RNA sequencing;subcutaneous;T cell receptor repertoire sequencing;T-Cell Activation;T-cell diversity;T-Cell Receptor;T-Lymphocyte;Testing;therapeutic target;tumor;Work

PROJECT_TITLE: Ablating Liver Metastases with SBRT to Enhance Immune Checkpoint Blockade in Melanoma

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative: The proposed program “Training in Advanced Data Analytics and Computational Sciences to End Drug-Related Harms” (TADA) will prepare a diverse cadre of 21st century social and behavioral science (SBS) researchers to develop transformative approaches to end the substance use disorder (SUD) crisis. Supported by 45 faculty mentors from 11 departments, TADA will prepare trainees to ethically, critically, and seamlessly integrate advanced data science methods into the SBS research lifecycle for SUD. Trainees will learn to: (1) Conduct theoretically-informed studies of distributions and ecologies of SUD-related harms using advanced data science methods; (2) Conduct theoretically-informed studies motivating and assessing policies and programmatic interventions that may affect SUD-related harms and services; (3) Disseminate findings to multiple stakeholder communities to strengthen efforts to end SUD-related harms; (4) Critically apply principles of the ethical and responsible conduct of research.

PI_NAMEs: COOPER, HANNAH LF (contact);SARKER, ABEED H;WALLER, LANCE A

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TITLE: Training in Advanced Data Analytics to End Drug-Related Harms (TADA)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(50)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Arthritis;Biomedical Imaging;Biotechnology;Brain Disorders;Chronic Pain;Gene Therapy;Genetics;Intellectual and Developmental Disabilities (IDD);Mucopolysaccharidoses (MPS);Neurosciences;Pain Research;Pediatric;Rare Diseases;Regenerative Medicine;Transplantation

ORG_CITY: ORANGE

ORG_NAME: CHILDREN'S HOSPITAL OF ORANGE COUNTY

PHR: PROJECT NARRATIVE Mucopolysaccharidosis type I (MPS I) is a genetic disorder which causes serious and progressive symptoms beginning in early childhood, especially the central nervous system with loss of neurodevelopmental milestones, deterioration of neurons, and loss of white matter; and the joints with stiffness, decline in mobility, and painful degeneration. Hematopoietic stem cell transplant, a treatment for MPS I, must be done as early as possible to prevent neurodegeneration, but is risky and does not completely take care of these difficult symptoms, leaving children with intellectual disability and severe deficits performing activities of daily living. The proposed studies will evaluate a multimodal gene therapy approach in the canine model of MPS I to simultaneously remedy multiple refractory aspects of the disease, paving the way towards future therapy for people with MPS I that is less risky, while comprehensively addressing symptoms.

PI_NAMEs: WANG, RAYMOND YU JEANG (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Activities of Daily Living;Address;adeno-associated viral vector;Affect;Aorta;arthropathies;Biochemistry;Biological Models;biomarker identification;biomechanical test;Biomechanics;Blood;Blood - brain barrier anatomy;Body System;Brain;Brain imaging;burden of illness;canine model;Canis familiaris;Cardiac;Cardiomyopathies;Caring;Cartilage;Central Nervous System;Central Nervous System Diseases;Cerebral cortex;Cessation of life;Child;Chondrocytes;Circulation;Clinical assessments;Clinical Trials;Cognitive;Cognitive deficits;cognitive function;combination gene therapy;Contracture;daily pain;Data;Deformity;Degenerative polyarthritis;Dependovirus;design;Deterioration;Development;Dilatation - action;Disease;disease phenotype;Disease Progression;Dose;Dysplasia;early childhood;Early treatment;Engraftment;enzyme activity;enzyme replacement therapy;Enzymes;experience;Future;gene replacement;gene replacement therapy;gene therapy;Genes;Genetic Diseases;Glycosaminoglycans;graft vs host disease;Heart;hematopoietic engraftment;Hematopoietic Stem Cell Transplantation;Hepatic;Hepatosplenomegaly;Histopathology;Human;Hyperplasia;Hypertrophy;IGF Type 2 Receptor;Image;Imaging Techniques;Immobilization;Immune Tolerance;Immunocompromised Host;immunoreaction;Impaired cognition;improved;Infant;Inflammation;Infusion procedures;Injections;Intellectual functioning disability;Intravenous;joint inflammation;Joints;Knowledge;L-Iduronidase;Life;Life Expectancy;Ligaments;Liver;liver imaging;Long-Term Effects;Magnetic Resonance Imaging;Methods;Mobility decline;Modality;Modeling;Morphology;Mucopolysaccharidoses;Mucopolysaccharidosis I;Mucopolysaccharidosis I H;Mucopolysaccharidosis I S;multimodality;neonatal period;Neonatal Screening;neonate;Nerve Degeneration;Neurocognition;Neurocognitive;neuroimaging;Neurons;neuropathology;novel;novel strategies;Pain;Pathology;Patients;Penetration;Pennsylvania;Peripheral;Persons;Phenotype;Play;Positioning Attribute;pre-clinical;prevent;Proliferating;Property;Protocols documentation;Quality of life;Reaction;Recombinants;Recommendation;Refractory;Rehabilitation therapy;Research Personnel;response;restoration;Risk;Role;Satellite Viruses;screening panel;Sepsis;Services;Spinal Canal;Spinal Cord Diseases;Spleen;Stem cell transplant;Stenosis;Structure;symptomatology;Symptoms;Synovial Membrane;tandem mass spectrometry;Techniques;Testing;Therapeutic;Therapeutic Effect;Tissues;Toxic effect;tractography;transgene expression;Translating;treatment response;Universities;Venous;white matter;Work

PROJECT_TITLE: Combination Gene Therapy for Treatment of Canine Mucopolysaccharidosis Type I

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Bioengineering;Biomedical Imaging;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

PHR: Project Narrative Positron Emission Tomography (PET) is a medical technique that creates images of biochemical processes occurring in vivo, where radioactive molecules (also known as PET ligands) are injected and the distributions of those molecules are measured using a PET scanner. As the burden of psychiatric illnesses in the United States and worldwide is high, there is a critical need to develop novel PET ligands to image vasopressin-related neuropsychiatric disorders, including autism spectrum disorder. This work will develop key tools designed to advance the scientific understanding of arginine vasopressin receptor 1A in the central nervous system and facilitate the discovery of neurotherapeutics.

PI_NAMEs: LIANG, STEVEN H (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: ABCB1 gene;Affinity;antagonist;Argipressin;argipressin receptor;ASD patient;autism spectrum disorder;Autopsy;Autoradiography;Binding;Binding Proteins;Biochemical Process;Biodistribution;Biological;Biological Process;Blood specimen;Brain;brain tissue;Cell Line;Central Nervous System;Chemistry;Chinese Hamster Ovary Cell;clinical biomarkers;design;Development;Docking;Dose;drug discovery;Evaluation;experimental study;Functional disorder;Generations;Hormones;Human;Image;image translation;Imaging Device;imaging study;improved;In Vitro;in vitro Assay;in vivo;Kinetics;Knockout Mice;Label;Lead;Libraries;Ligands;lipophilicity;Liver Microsomes;Measures;Mediating;Medical;Mental disorders;Messenger RNA;Methylation;Modeling;Molecular;Monitor;mouse model;Mus;National Institute of Mental Health;Neurodevelopmental Disorder;neuropsychiatric disorder;nonhuman primate;novel;novel therapeutics;Pathway interactions;Penetration;Permeability;Pharmaceutical Chemistry;pharmacokinetics and pharmacodynamics;Plasma;Plasma Proteins;Positron-Emission Tomography;Radioactive;Radiolabeled;Radioligand Assay;radiotracer;Receptor Gene;Research;response;Rodent;Scientific Advances and Accomplishments;Selection Criteria;Signal Transduction;Site;species difference;Specificity;stable cell line;Techniques;Testing;tool;Toxic effect;Transgenic Organisms;Translations;United States;uptake;V1a vasopressin receptor;Validation;Vasopressins;Work

PROJECT_TITLE: PET ligand discovery for arginine vasopressin

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS-R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: SAN ANTONIO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Narrative: In prior work, we have established the latent variable “δ” (for dementia) as a dementia-specific cognitive phenotype. δ can improve dementia-related clinical trials. This project pilots several methodological advances: 1. The use of telephone assessment to minimize recruitment and assessment costs (and protect participants from potential SARS-cov-2 exposure). 2. The use of a latent dementia severity metric (dECog) to equate study groups on baseline dementia severity. 3. The use of a novel “Line of Identity (LOI)” algorithm to select cases most likely to benefit from intervention (an example of precision medicine). 4. The use of a latent dementia severity metric (dTEL) as a comprehensive dementia-specific outcome. 5. The use of a latent biomarker construct as a mediator, potentially establishing a novel mechanism to explain acetylcholine esterase inhibitor (AChEI) effects.

PI_NAMEs: ROYALL, DONALD R (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: 2019-nCoV;Acetylcholinesterase;Acetylcholinesterase Inhibitors;adipokines;Adipose tissue;Algorithms;Alzheimer's Disease;Alzheimer's disease therapy;Aricept;Back;Biological Assay;Biological Markers;Blood;Caring;Clinical;Clinical Trials;Cognitive;cognitive performance;cohort;cost;Cost Analysis;COVID-19 pandemic;Data;demented;Dementia;donepezil;Double-Blind Method;Elderly;Equation;Factor Analysis;Future;Homologous Gene;Impaired cognition;improved;Individual;Inflammatory;informant;Intervention;Left;Measures;Mediating;Mediation;Mediator;Medicine;Methodology;Methods;Modification;neuroimaging;novel;novel therapeutics;open label;Outcome;Participant;Patient Selection;Persons;Pharmaceutical Preparations;Phenotype;Pilot Projects;Plasma;Postdoctoral Fellow;pre-clinical;precision medicine;Process;prospective;Proteins;Protocols documentation;Psychometrics;recruit;Research;SARS-CoV-2 exposure;Serum;Severities;Specific qualifier value;Subjects Selections;Telephone;Testing;Texas;unvaccinated;Work

PROJECT_TITLE: Novel Methods for Clinical Trials in Dementia and Cognitive Decline


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The scope of quality improvement programs that focus on improving the utilization of first-line evidence-based medical therapies in patients with heart failure is limited by mechanisms to identify those who are eligible for specific treatments. The current proposal aims to design automated tools to identify patients eligible for heart failure therapies using various data components already captured in the electronic health record in hospitalized patients. The proposal will then pilot test strategies of improving treatment utilization with electronic alerts delivered to clinicians based on these tools.

PI_NAMEs: KHERA, ROHAN  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Adrenergic beta-Antagonists;Adult;advanced analytics;Affect;Algorithm Design;Algorithms;analytical tool;Anaphylaxis;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Angiotensins;antagonist;automated algorithm;automated assessment;Automated Clinical Decision Support;Automation;Bradycardia;Cardiovascular Diseases;Cardiovascular system;care delivery;career;career development;Caring;Clinical;clinical care;clinical decision support;Code;computing resources;Consensus;Coughing;Critical Care;Data;Databases;Decision Making;deep learning;design;Development Plans;Diagnosis;Documentation;Echocardiography;Electronic Health Record;Electronics;Eligibility Determination;Ensure;Environment;Evaluation;evidence base;Evidence based treatment;experience;Failure;Feedback;Focus Groups;follow-up;Functional disorder;Goals;health data;Healthcare;Heart failure;Hospitalization;hospitalization rates;Hospitals;hyperkalemia;implementation strategy;improved;improved outcome;Individual;individual patient;Informatics;inhibitor;Institution;Intensive Care;K-Series Research Career Programs;Laboratories;Lead;Left;Low Cardiac Output;Machine Learning;Manuals;Measurement;Measures;Medical;Medical History;Medical Informatics;Medical Records;Mentors;Mentorship;Methodology;Mineralocorticoid Receptor;Modeling;mortality;Natural Language Processing;Neprilysin;open source;Outcomes Research;Outpatients;Patient Care;patient oriented;patient subsets;Patient-Focused Outcomes;Patients;Peptidyl-Dipeptidase A;Pharmaceutical Preparations;Phenotype;Physicians;pilot test;point of care;Process;programs;prospective;prototype;Provider;Qualifying;Qualitative Evaluations;Qualitative Research;Quality of Care;Random Allocation;Recommendation;Recording of previous events;Records;recruit;Registries;Reporting;Research;Research Methodology;Resources;Risk Reduction;skills;Source;Structure;structured data;support tools;Surveys;Systolic heart failure;Technology;Testing;Therapeutic;Therapeutic Agents;Time;time use;tool;Training;Treatment Failure;Validation;Ventricular

PROJECT_TITLE: Evaluating and Improving Utilization of Evidence-Based Medical Therapy in Patients with Heart Failure using Automated Tools in the Electronic Health Record

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ITHACA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative HIV-1-infected individuals who are under long-term anti-retroviral therapy, can effectively suppress plasma viremia, but remain predisposed to co-morbidities that are often attributed to hyperactivated and suboptimal immune functions. Recent indications that a sub-group of virus-infected cells called “active reservoirs” continue to generate viral RNAs and/or proteins during the treatment period could potentially contribute to the co- morbidities as well as relapse of viremia upon treatment interruption. We will extensively characterize the active viral persistence in lung alveolar macrophages to determine the roles of these reservoirs in viral rebound and immunological dysfunctions in therapy-suppressed individuals in order to identify molecular targets for their elimination.

PI_NAMEs: BOLIAR, SAIKAT  (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Address;Affect;Alveolar Macrophages;antiretroviral therapy;Binding;Biological;Biological Assay;Blood;Brain;CD4 Positive T Lymphocytes;Cell Death Induction;Cell Survival;cell type;Cells;Chronic;Clonality;Coculture Techniques;cohort;comorbidity;comparative;cytokine;cytotoxic;Data;Disease Progression;Disease remission;Effector Cell;Evolution;exhaustion;Feedback;Fluorescent in Situ Hybridization;Frequencies;Functional disorder;genetic makeup;Genetic Transcription;HIV-1;Human;human subject;Immune;immune activation;immune function;Immune System Diseases;Immunity;Immunologics;Individual;Interruption;Kinetics;Knowledge;Kupffer Cells;Length;Liver;loss of function;Lung;Lymphoid Cell;Macrophage;Macrophage Activation;Methods;Microglia;Molecular;Molecular Target;monocyte;Myelogenous;Myeloid Cells;Nature;Open Reading Frames;peripheral blood;Phagocytosis;Plasma;Population;prevent;Production;Productivity;Proviruses;Relapse;Reporting;Residual state;RNA;RNA Splicing;Role;SIV;Sorting;Stimulus;Subgroup;success;T-Lymphocyte;Tissues;Transcript;transcriptomics;Translations;treatment duration;Viral;Viral Proteins;viral rebound;Viral reservoir;viral RNA;Viremia;Virion;Virus;Virus Replication

PROJECT_TITLE: Virologic and immunologic impacts of active viral persistence in lung AMs of HIV-1-infected, cART-suppressed individuals

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Breastfeeding, Lactation and Breast Milk;Clinical Research;Cost Effectiveness Research;HIV/AIDS;Health Services;Infectious Diseases;Maternal Health;Pediatric;Pediatric - AIDS;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Progress toward elimination of pediatric HIV infection has stalled in recent years, primarily due to gaps in care for pregnant and lactating people with HIV and their infants. We propose to use a validated computer simulation model of mothers and infants to estimate and compare the clinical and economic impacts of alternative maternal interventions (HIV testing, pre-exposure prophylaxis, and antiretroviral therapy) and infant interventions (postnatal prophylaxis and testing), incorporating critical interactions between maternal treatment and infant prophylaxis and diagnosis. We will then develop, test, and apply simulation optimization methods and translate these results into online decision tools, to identify the packages of maternal and infant interventions that maximize clinical benefit and cost-effectiveness in a range of settings that reflect global variation in HIV epidemiology, healthcare delivery, and healthcare costs.

PI_NAMEs: CIARANELLO, ANDREA LYNNE (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Affect;Age;AIDS prevention;Antibodies;antiretroviral therapy;Award;Biological Assay;Birth;Breast Feeding;Caring;Child;Child Care;Childhood;Clinical;cohort;Complex;Computer Simulation;Continuity of Patient Care;cost effective;cost effectiveness;Costs and Benefits;Country;Creativeness;Data;Diagnosis;economic impact;economic value;Epidemiology;Evaluation;flexibility;Frequencies;Goals;Growth and Development function;Guidelines;Health;Health Care Costs;health care delivery;Health Services Accessibility;Healthcare;high risk;HIV;HIV Infections;Human immunodeficiency virus test;improved;improved outcome;Incidence;Individual;Infant;Infant Health;infant infection;Infection;infection risk;Injectable;Intervention;Ivory Coast;Laboratories;Lactation;Link;Machine Learning;Maternal Health;maternal outcome;meetings;Methods;Modeling;models and simulation;Mothers;National Institute of Child Health and Human Development;neutralizing antibody;next generation;NIH Office of AIDS Research;novel;Nucleic Acid Amplification Tests;Oral;Outcome;Output;pediatric AIDS;pediatric human immunodeficiency virus;pediatric human immunodeficiency virus infection;Persons;Pharmaceutical Preparations;point of care;Policy Analysis;Policy Maker;Populations at Risk;postnatal;pre-exposure prophylaxis;Pregnancy;pregnant;Prevalence;prevent;Prevention;Prevention strategy;Preventive;programs;Prophylactic treatment;Publishing;Regimen;Research Methodology;Research Priority;Resistance;Resources;Risk;Sensitivity and Specificity;simulation;South Africa;Technology;Testing;Therapeutic;tool;Training;Translating;transmission process;Treatment Protocols;United States National Institutes of Health;Variant;Viral;Viremia;web-based tool;Woman;Work;World Health Organization;Zimbabwe

PROJECT_TITLE: Reaching for the end of pediatric AIDS: Modeling strategies to strengthen the maternal-child HIV care continuum and eliminate vertical HIV transmission.

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project narrative The establishment of left-right (LR) asymmetry is a critical event required for the correct positioning of internal organs. Defects in human LR axis formation cause birth defects of the heart, vasculature, lungs, and intestinal tract. Our research aims to discover the central mechanism that links Hedgehog (Hh) signaling pathway and transforming growth factor-b (TGF-b) signaling pathway to the establishment of left-right asymmetry.

PI_NAMEs: ZHENG, XIAOYAN  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Biochemical;Cilia;Competence;Congenital Abnormality;Defect;Diagnosis;Embryo;Erinaceidae;Event;experimental study;falls;fluid flow;gene network;Generations;genetic approach;heart defect;homeodomain;Human;Intestines;Lateral;Left;Link;Lung;Mediating;Mesoderm;Molecular;Morphogenesis;Mus;Neurons;neurotrophic factor;Nodal;novel;Organ;parent grant;Pathway interactions;Pattern;Play;Positioning Attribute;preventive intervention;Regulation;Research;response;Role;Rotation;secretory protein;Side;Signal Pathway;Signal Transduction;Source;Structure;Therapeutic Intervention;transcription factor;Transcriptional Regulation;Transforming Growth Factor beta;Transforming Growth Factors;Travel;Vertebrates;Work

PROJECT_TITLE: Linking of Hh and TGF-b signaling in LR asymmetry_Diversity Supplement

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Widely-adopted targets such as “95-95-95” have fueled tremendous progress in access and effective use of HIV treatment, but no analogous targets exist for HIV pre-exposure prophylaxis (PrEP). This study will estimate the relationship between plasma concentrations of PrEP drugs and their effects on reducing HIV acquisition risk, the relationship between PrEP program participation and non-pharmaceutical HIV risk reduction, and implications for how different combinations of PrEP coverage and adherence across population segments could lead to achievement of HIV epidemic goals. The evidence produced by this study could not only inform the development of PrEP targets, but also enable measurement of progress toward these targets using a Population-Based HIV Impact Assessment (PHIA) for PrEP.

PI_NAMEs: BERSHTEYN, ANNA  (contact);DIMITROV, DOBROMIR ;HABERER, JESSICA ELIZABETH

PROGRAM_OFFICER_NAME: SHARP, GERALD B

PROJECT_TERMS: Achievement;active control;Adherence;Adopted;Adult;Advocate;Africa South of the Sahara;Age;AIDS prevention;Anti-viral Agents;Automobile Driving;Behavioral;Bioethics;Blood specimen;Cause of Death;civil society;cohort;community advisory board;comparative;Concentration measurement;cost effective;Country;Data;design;Development;Diagnosis;Epidemic;experience;Female Adolescents;Formulation;General Population;Goals;Government;Guidelines;Heterosexuals;HIV;HIV Infections;HIV risk;HIV Seronegativity;HIV/AIDS;Home;Human immunodeficiency virus test;implementation study;Incidence;Individual;innovation;interest;International Agencies;Interruption;Kenya;Kidney Function Tests;Licensure;Maps;markov model;Measurement;Measures;meetings;men who have sex with men;Methods;Modeling;Monitor;mortality;multilevel analysis;Observational Study;Oral;Participant;Persons;Pharmaceutical Preparations;pharmacologic;Placebos;Plasma;Policy Maker;Population;population based;Population Group;Population Surveillance;pre-exposure prophylaxis;preference;programs;Reporting;Research;Research Personnel;Risk;Risk Behaviors;Risk Reduction;scale up;Scientific Advances and Accomplishments;Scientist;self testing;Series;seroconversion;social stigma;South Africa;Study models;Surveys;Sustainable Development;Time;transmission process;Viral;Viral Load result;Woman;World Health Organization;young woman

PROJECT_TITLE: Drug concentration measurement for HIV prevention targets: toward a population-based HIV impact assessment (PHIA) for PrEP


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;HIV/AIDS;Infectious Diseases;Microbiome;Pediatric;Pediatric - AIDS

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The development of the oral microbiome among children at the stage of primary dentition is an important predictor of their future health and well-being. Understanding the changes in the oral microbiome from ages 3-5 years among HIV-exposed uninfected children will inform precise microbiota-targeted interventions. This research provides evidence-based information for integrating HIV care and dental care in resource-limited settings.

PI_NAMEs: WANG, YAN  (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: 14 year old;3 year old;Affect;Africa South of the Sahara;Age;age stratification;aged;antiretroviral therapy;Area;bacterial community;Behavior;Birth;Breast Feeding;Caring;Cause of Death;Child;cohort;cost effective;County;Data;Death Rate;deciduous tooth;Dental;Dental Care;Dental caries;Development;Disease;Educational process of instructing;evidence base;Face;follow-up;Foundations;Future;Goals;Growth;Health;Health Status;High Prevalence;HIV;HIV Infections;HIV Seropositivity;HIV-exposed uninfected infant;HIV/AIDS;Hospital Referrals;Hospitalization;improved;Incidence;Infrastructure;Intervention;Kenya;Life;Medical;Methods;microbial;microbiome;microbiota;Modeling;Mother-to-child HIV transmission;Mothers;Mouth Diseases;nutrition;Oral;oral condition;Oral health;Oral Manifestations;oral microbial community;oral microbiome;Outcome;Parents;Pattern;Personal Satisfaction;Phenotype;population health;Pregnant Women;prenatal exposure;Prevention;Primary Care;Primary Dentition;Quality of life;Research;Research Personnel;Research Project Grants;Resource-limited setting;RNA, Ribosomal, 16S;routine care;Saliva;Sampling;scale up;sex;Social Interaction;Swab;Time;transmission process;Visit

PROJECT_TITLE: Longitudinal Oral Microbiome for HIV/HEU/HUU Children Aged 3-4 in Western Kenya

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Dental, Oral, and Craniofacial Disease;HIV/AIDS;Infectious Diseases;Lung;Microbiome

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE (STATEMENT OF PUBLIC HEALTH RELEVANCE) People with HIV are at increased risk of developing chronic obstructive pulmonary disease (COPD), which is the third leading cause of death worldwide, but we do not fully understand why. To address this knowledge gap, we will study associations between the oral microbiome, systemic inflammation, and COPD among people with HIV in Botswana. This information will improve our understanding of how COPD develops in people with HIV and may lead to the development of new ways to treat COPD using the microbiome.

PI_NAMEs: PATEL, SWETA MAHESH (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Africa South of the Sahara;Age;Age Years;Award;Behavioral;biobank;Biological Markers;biomass smoke;Botswana;career;Cause of Death;Cessation of life;Characteristics;Child;Chronic;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Clinic;clinical infrastructure;Clinical Research;clinical training;comorbidity;Complex;Corynebacterium;cytokine;Data;Development;Diagnosis;Equity;Exposure to;Frequencies;Future;global health;Goals;Growth;high risk;HIV;HIV/AIDS;Home;host microbiome;Impairment;improved;Individual;Inflammation;Inflammatory;inflammatory marker;Interleukin-6;K-Series Research Career Programs;Knowledge;Lead;Link;low and middle-income countries;lung microbiome;Master of Science;Measurement;Measures;Metabolic Pathway;metagenomic sequencing;microbiome;microbiome alteration;microbiome composition;microbiome research;Modification;mortality;multiple omics;novel;Occupational;Oral;Oral Characters;oral microbiome;Participant;pathogenic bacteria;Patients;Persons;Plasma;Pneumonia;Population;Prevotella;public health relevance;pulmonary function;pulmonary function decline;Pulmonary function tests;Pulmonology;Qualifying;recruit;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;respiratory microbiome;respiratory pathogen;Respiratory Signs and Symptoms;Risk;Risk Factors;sample collection;Sampling;Scientist;Severity of illness;skill acquisition;skills;Spirometry;Streptococcus;Streptococcus pneumoniae;systemic inflammatory response;Training;United States;United States National Institutes of Health;Work

PROJECT_TITLE: The impact of the oral microbiome on pulmonary function among people with HIV in Botswana

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (OA)]


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: OVERALL – PROJECT NARRATIVE Viruses contribute to at least 21 different human cancers, representing approximately 15% of all human cancers. Understanding the biology of these human tumor viruses and how they cause cancer will provide new approaches for preventing and treating the associated cancers. In this program project grant a highly interactive group of seven investigators and their laboratory members engage in collaborative research focused on two objectives: to elucidate the life cycles of and transformation by human tumor viruses and to translate this understanding into the identification of targets for specific anti-viral, anti-tumor therapies.

PI_NAMEs: LAMBERT, PAUL F. (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Automobile Driving;Bioinformatics;Burkitt Lymphoma;Cancer Etiology;cancer therapy;carcinogenesis;chronic infection;Collaborations;collaborative environment;Disease;Drug Targeting;efficacy evaluation;Engineering;Epithelial Cells;Epithelium;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Malignant Neoplasm;Etiology;experimental study;Family;Fertilization;Fostering;Funding;Genes;genome wide screen;Goals;Herpesviridae;Histology;Human;Human Biology;Human Genetics;Human Herpesvirus 4;Human Herpesvirus 8;Human Papillomavirus;Human papillomavirus 16;Immunity;Immunotherapy;innovation;insight;instrumentation;Knowledge;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;Lead;Life Cycle Stages;lymphoid oncogenesis;Lymphomagenesis;Lytic;Maintenance;Malignant Neoplasms;Mediating;member;Microscopy;Mission;Modeling;Molecular Biology;Molecular Genetics;mouse model;mutant;Neoplasms;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Oncogenic Viruses;Papillomavirus;Pathogenesis;Pathway interactions;prevent;Prevention;primary effusion lymphoma;Production;Productivity;Program Research Project Grants;programs;Publishing;Research;Research Personnel;Role;statistics;synergism;therapeutic target;Translating;tumor;tumor microenvironment;tumorigenesis;Viral;Viral Genes;virology;Virus;virus related cancer;Work

PROJECT_TITLE: Molecular Biology and Genetics of Human Tumor Viruses

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-L (O1)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cervical Cancer;Emerging Infectious Diseases;Estrogen;Genetics;HIV/AIDS;Human Genome;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

PHR: PROJECT 1 − PROJECT NARRATIVE High-risk human papillomaviruses are the most common sexually transmitted virus and cause 5% of all human cancers. These cancers arise as a result of persistent infections that our bodies fail to eliminate. In this project, we explore ways to activate our own immune system to eradicate the persistent infections that give rise to these cancers and to improve clinical approaches to treating the cancer that do arise.

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Anogenital cancer;antagonist;Anus;B-Lymphocytes;carcinogenesis;CD8-Positive T-Lymphocytes;cell mediated immune response;Cells;Cervical;cervical carcinogenesis;cervicovaginal;chronic infection;Clinic;Clinical;Collaborations;design;Detection;Development;Effectiveness;ESR1 gene;Estrogens;experience;experimental study;Faculty;Foundations;Frequencies;Funding;Genes;Genomics;Goals;Head and Neck Cancer;high risk;HIV;HPV positive;Human;Human Genetics;Human Herpesvirus 4;Human Herpesvirus 8;human model;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Immune;immune checkpoint blockade;Immune Evasion;Immune response;Immune system;Immunity;Immunocompetent;Immunologic Surveillance;Immunologics;Immunosuppression;Immunotherapy;improved;inducible gene expression;Integration Host Factors;Keratin;keratinocyte;Knockout Mice;Learning;Life Cycle Stages;Macrophage;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;Modeling;Molecular Biology;Molecular Genetics;mouse model;Mus;Neoplasms;neoplastic cell;novel therapeutics;Oncogenes;Oncogenic Viruses;Oral;Papillomavirus;Papillomavirus Infections;Pathogenesis;Pathway interactions;Persons;Physiological;pre-clinical;Pre-Clinical Model;Prevention;primary effusion lymphoma;Productivity;Resistance;response;Role;Severities;sexually transmitted virus;single-cell RNA sequencing;Specificity;Stress;Testing;three dimensional cell culture;Time;transcriptomic profiling;Translating;tumor;tumor immunology;tumor microenvironment;tumor-immune system interactions;Viral;Virus;women's treatment;Xenograft procedure

PROJECT_TITLE: Project 1 - Characterize the Mechanism by Which Papillomaviruses Evade Host Immunity


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: PROJECT 2 − PROJECT NARRATIVE Epstein-Barr Virus and Kaposi's Sarcoma Herpesvirus are human tumor viruses that cause lymphomas. We are identifying how they cause Burkitt Lymphoma and Primary Effusion Lymphomas to foster development of treatments for these cancers.

PI_NAMEs: SUGDEN, WILLIAM M. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Animal Model;Apoptosis;B-Lymphocyte Subsets;B-Lymphocytes;body cavity;Burkitt Lymphoma;cancer therapy;cell growth;Cell Line;cell transformation;Cells;Characteristics;co-infection;Collaborations;Complex;CRISPR screen;CRISPR/Cas technology;Dependence;Development;Early identification;Ensure;Environment;experience;Fostering;gammaherpesvirus;Gene Expression;Genes;genome-wide;Greater sac of peritoneum;Growth;Human;Human Genetics;Human Herpesvirus 4;Human Herpesvirus 8;In Vitro;Individual;Infection;Interleukin-10;Kaposi Sarcoma;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;Libraries;lymphoid oncogenesis;Lymphoma;Lymphoma cell;Lymphomagenesis;Malignant lymphoid neoplasm;Malignant Neoplasms;Measures;Mediating;member;Methods;Molecular Biology;Molecular Genetics;Mus;mutant;Mutate;novel;novel strategies;Nuclear Import;Oncogenic Viruses;Pathway interactions;Peripheral;Peritoneal;Play;pre-clinical;primary effusion lymphoma;Research Personnel;Role;Signal Transduction;Testing;therapy development;Time;Tonsil;tumor growth;tumorigenesis;Universities;Virus;Wisconsin;Work;Xenograft procedure

PROJECT_TITLE: Project 2 - Uncovering Mechanisms of the Lymphoid Oncogenesis of Epstein-Barr Virus and Kaposi's Sarcoma


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;HIV/AIDS;Infectious Diseases

PHR: PROJECT 3 – PROJECT NARRATIVE Latent Epstein-Barr virus (EBV) infection is an important cause of human tumors, especially lymphomas and nasopharyngeal carcinomas, in both immunocompetent and immunosuppressed hosts. Lytic EBV infection (in which infectious viral particles are produced) causes lesions on the tongue (oral hairy leukoplakia), particularly in HIV-infected patients. In this proposal, we will define how the EBV-encoded latent membrane protein 1 (LMP1) promotes epithelial cancers by inducing proliferation and inhibiting differentiation through effects on the tumor suppressor Hippo pathway. We will also determine the mechanism(s) by which epithelial cell differentiation promotes lytic EBV infection in normal epithelial cells. Finally, we will ask whether FDA- approved drugs which alter Hippo pathway signaling can be used to treat human diseases caused by latent and/or lytic EBV infection in epithelial cells.

PI_NAMEs: KENNEY, SHANNON CELESTE (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;cancer cell;carcinogenesis;Carcinoma;Cell Differentiation Induction;Cell Differentiation process;Cell Line;Cells;Collaborations;Dasatinib;Epithelial Cells;Epithelium;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;FDA approved;Generations;Genes;Growth;Hairy Leukoplakia;HIV;Human;human disease;Human Genetics;Human Herpesvirus 4;Immunocompetent;Immunocompromised Host;Impairment;In Vitro;in vivo;inhibitor;inhibitor therapy;keratinocyte;LATS1 gene;Lesion;Lymphoma;Lytic;Lytic Phase;malignant stomach neoplasm;Mediating;Membrane Proteins;Microscopy;Molecular Biology;Molecular Genetics;Nasopharyngeal Undifferentiated Carcinoma;Nasopharynx Carcinoma;neoplastic cell;novel;Oncogenic Viruses;Oncoproteins;Oral;oral cavity epithelium;particle;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphorylation;PRDM1 gene;Proliferating;Proteins;Recombinants;Reporter;Research Personnel;Role;Signal Pathway;small molecule;Squamous Differentiation;Telomerase;Tongue;tumor;Tumor Suppressor Proteins;Viral;Viral Proteins;Virus;virus core;Virus Diseases;Xenograft procedure

PROJECT_TITLE: Project 3 - Latent and Lytic EBV Infection in Epithelial Cells


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;HIV/AIDS;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: PROJECT 4 − PROJECT NARRATIVE Diffuse large B cell lymphoma (DLBCL), the most common form of aggressive lymphoma, is actually a collection of multiple cancers (subtypes) that have similar clinical presentations but require different therapy. Overall, 5- 10% of DLBCLs are EBV infected, but we do not know the which DLBCL genetic subtypes are EBV-associated. In this project, we will determine these subtypes, how EBV promotes their development, and identify the subtype- specific therapeutic targets.

PI_NAMEs: JOHANNSEN, ERIC C (contact)

PROJECT_TERMS: Antigen Targeting;B-Cell Lymphomas;B-Lymphocytes;BCL6 gene;cancer type;Carcinoma;chemotherapy;Classification;Clinical;Collaborations;Collection;Complement;CRISPR screen;Data;Dependence;Development;Disease;driver mutation;DTX1 gene;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Lymphoma;falls;Gene Expression;Gene Expression Profiling;gene interaction;Genes;Genetic;genome-wide;Growth;Histologic;HIV;Human Genetics;Human Herpesvirus 4;humanized mouse;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;improved;In Vitro;Incidence;Institution;large cell Diffuse non-Hodgkin's lymphoma;LMP1;Lymphoma;Macrophage-1 Antigen;Malignant Neoplasms;Molecular;Molecular Biology;Molecular Genetics;Mus;Mutate;Mutation;notch protein;Oncogenes;Oncogenic Viruses;Pathogenesis;Pathway interactions;Patients;Pattern;Persons;pharmacologic;Prognosis;public database;Reporter;Risk;Role;Signal Induction;targeted agent;targeted treatment;Therapeutic;therapeutic target;transcriptome sequencing;tumor;Umbilical Cord Blood;validation studies;Virus

PROJECT_TITLE: Project 4 - Defining the Role of EBV in DLBCL Pathogenesis and Identification of Therapeutic Targets


PHR: CORE A – PROJECT NARRATIVE In this multi-investigator Program Project Grant (PPG), seven science laboratories at the University of Wisconsin pursue research to understand how viruses cause human cancer and to discover ways to prevent and treat these cancers. The Administrative Core provides two important services to the PPG. First, it provides oversight, as well as administrative and financial support to ensure that the science proposed can be carried out. Second, it provides expertise in statistics and bioinformatics to ensure that conclusions drawn are valid and to discover new insights based upon the analysis of high-dimensional genomics data.

PROJECT_TERMS: Animals;Bioinformatics;Biological Sciences;Biometry;Collaborations;Computational Science;Computer software;Data Set;design;Elements;Ensure;experience;experimental study;Faculty;Financial Support;Funding;genome-wide analysis;genomic data;Grant;high dimensionality;Human;Human Genetics;insight;Laboratories;laboratory experiment;Malignant Neoplasms;member;Molecular Biology;Molecular Genetics;Occupational activity of managing finances;Oncogenic Viruses;Paper;prevent;professor;Program Research Project Grants;programs;Publishing;Reporting;Research;Research Personnel;Science;Scientist;Services;Statistical Data Interpretation;statistics;Testing;Time;Training;Universities;Update;Virus;Wisconsin;Writing

PROJECT_TITLE: Core A - Administrative/Statistics Core


PHR: CORE B – PROJECT NARRATIVE The Instrumentation and Imaging Core (Core B) provides shared instrumentation and high-resolution imaging services needed for the success of all Projects in this program. The core also coordinates maintenance and training, and aims to advance the development of new, innovative tools for understanding the replication cycles of cancer-associated viruses and how they cause human diseases.

PI_NAMEs: SHERER, NATHAN M (contact)

PROJECT_TERMS: 3-Dimensional;Advanced Development;Biochemical;Biological Assay;Cells;commune;Confocal Microscopy;design;Detection;Disease;DNA;Epithelial Cells;Equipment;Fee-for-Service Plans;Fluorescent in Situ Hybridization;Formalin;Freezing;Funding;Gene Expression;gene product;Generations;Goals;high resolution imaging;Histology;Histopathology;Human;human disease;Human Genetics;Image;imager;Imaging Device;Imaging technology;innovation;Instruction;instrument;instrumentation;light microscopy;live cell imaging;Maintenance;Malignant Neoplasms;Measures;member;Microscope;microscopic imaging;Microscopy;Molecular Biology;Molecular Genetics;mouse model;multimodality;Names;new technology;Nucleic Acids;Oncogenic Viruses;Paraffin Embedding;Pathology;Preparation;programs;Proteins;Resolution;Resource Sharing;Resources;RNA;Services;Signal Transduction;Spectrophotometry;Speed;success;Supporting Cell;technology development;temporal measurement;Time;Tissue Sample;Tissues;tool;Training;Tumor Virus Infections;Viral;Virus;virus related cancer;Virus Replication;Visualization;Work

PROJECT_TITLE: Core B - Instrumentation


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases

PHR: CORE C – PROJECT NARRATIVE The purpose of this Virus Core is to provide time and cost-efficient access to validated, high-titer stocks of the wild-type and mutant viruses and lentiviral libraries required for the proposed studies of all six research groups of this Program.

PROJECT_TERMS: Antibiotic Resistance;Bacterial Artificial Chromosomes;bioinformatics pipeline;Capsid Proteins;Cell Line;Cells;cellular transduction;Collaborations;Complement;Core Facility;Cost efficiency;cost efficient;CRISPR/Cas technology;Data;DNA;Ensure;Escherichia coli;Eukaryotic Cell;Fostering;Generations;Genes;Genome;Herpesviridae;Human Genetics;Human Herpesvirus 4;Human Herpesvirus 8;Human Papillomavirus;Individual;interest;Laboratories;Lentivirus;Libraries;Luciferases;mammary;member;Methods;Molecular Biology;Molecular Genetics;Mus;mutant;Mutation;next generation sequencing;Nude Mice;Oncogenic Viruses;Papillomavirus;Pharmaceutical Preparations;Phenotype;Plasmids;programs;protein expression;Protocols documentation;Publishing;Quality Control;Research;resistance gene;retroviral transduction;Retroviral Vector;Retroviridae;Standardization;Time;Validation;Variant;vector;Viral;Virion;Virus

PROJECT_TITLE: Core C - Virus/Vector


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Human Fetal Tissue;Infectious Diseases;Liver Disease

ORG_CITY: Princeton

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Public health narrative Coinfection with HBV and HIV-1 is common, and HIV coinfection can exacerbate progression of viral hepatitis and accelerate liver disease progression. Our proposed work will use a cutting-edge humanized mouse model to test novel approaches for gaining insights into the mechanisms of HBV persistence in the context of HBV/HIV coinfection.

PI_NAMEs: PLOSS, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;adenovirus mediated delivery;Affect;Animal Model;anti-hepatitis B;Anti-viral Therapy;antigen-specific T cells;antiretroviral therapy;Biochemical;Cause of Death;Cell Physiology;Cells;Chronic;Chronic Hepatitis B;chronic infection;Circular DNA;Circulation;Cirrhosis;Clinical Data;co-infection;cofactor;combat;Complex;Data;Disease Progression;DNA;DNA Repair;Double Stranded DNA Virus;end stage liver disease;Engraftment;Family;Foundations;Genetic;Goals;Hepadnaviridae;Hepatitis B Infection;Hepatitis B Virus;Hepatitis Viruses;Hepatocyte;Highly Active Antiretroviral Therapy;HIV;HIV Infections;HIV-1;Human;humanized mouse;immune function;immune health;Immune response;Immune system;Immunity;Immunology;Impairment;improved;In Vitro;in vivo;Incidence;Individual;Inflammation;insight;Integration Host Factors;Knock-out;Lesion;Liver;Liver diseases;Liver Fibrosis;Measures;Modeling;Monitor;Morbidity - disease rate;mortality;mouse genetics;mouse model;Mus;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Pathogenesis;patient subsets;Patients;Persons;Pharmaceutical Preparations;Polymerase;Preventive vaccine;Primary carcinoma of the liver cells;Public Health;Recombinants;Relaxation;repaired;Research;Risk;SLC19A1 gene;System;T cell response;Technology;Testing;Therapeutic;Viral;Viral Genome;Viral hepatitis;Viremia;virology;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Targeting hepatitis B virus cccDNA during HBV/HIV co-infection

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Nutrition

ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE Neuronal metabolism and energy deficits have been implicated in many neurodegenerative and neurological disorders, including Alzheimer's disease, Parkinson's diseases, epilepsy and schizophrenia. However, our current understanding of the molecular mechanisms of metabolic dysfunction leading to diseases is cursory at best. This proposal aims to identify fast spiking neuron specific energy generation pathways in the brain to determine how metabolism adapts to changes in neuronal activity and drives higher-order cognitive processes, such as long-term memory and sensory processing.

PI_NAMEs: PEKKURNAZ, GULCIN  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Acute;Alzheimer's Disease;Alzheimer's disease risk;Astrocytes;ATP Synthesis Pathway;Automobile Driving;awake;Biochemical;Bioenergetics;Bioinformatics;Brain;Brain Diseases;Brain region;brain tissue;Buffers;Calcium;Calcium-Binding Proteins;cell type;Cells;Cognition;Cognition Disorders;Cognitive;cognitive control;cognitive function;cognitive process;complex IV;Conscious;Consumption;cost;Crista ampullaris;Data;density;Development;Disease;Electrophysiology (science);Energy Metabolism;Energy-Generating Resources;Epilepsy;Excitatory Synapse;Fasting;feeding;Fire - disasters;Foundations;Frequencies;Functional disorder;Generations;Genetic;Glucose;glucose metabolism;Glycolysis;Goals;Hippocampus;Homeostasis;Impaired cognition;in vivo;Individual;information processing;Injections;insight;Interneurons;Investigation;knock-down;Link;long term memory;mature animal;Measures;meetings;Memory;Mental Health;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;Minor;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;motor behavior;Mus;Mutation;NADH;Nervous System Disorder;network dysfunction;neural circuit;neural network;Neurodegenerative Disorders;neuronal circuitry;neuronal metabolism;Neurons;neurophysiology;neuropsychiatric disorder;neuroregulation;novel;novel therapeutics;nutrition;Oxidation-Reduction;Oxidative Phosphorylation;Parkinson Disease;Parvalbumins;patch clamp;Pathway interactions;Pattern;Perception;Phenotype;Physiology;Production;Property;Protein Isoforms;Proteins;Proteome;Proteomics;Publishing;Regulation;Respiration;response;Schizophrenia;selective expression;sensor;Sensory;single-cell RNA sequencing;Slice;Synapses;synaptic function;Testing;transcriptome sequencing;Viral;Work

PROJECT_TITLE: Defining the metabolic principles of neuronal network oscillations

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Natural Products

ORG_DEPT: CHEMISTRY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Research Supplement to Promote Diversity in Health-Related Research The rocaglates and aglains are classes of natural products isolated from various Aglaia plant species which have shown a variety of favorable biological activities including anticancer, anti-inflammatory, and antiviral activities. As outlined in the Diversity Supplement application, development of catalytic, asymmetric synthesis approaches to these natural product scaffolds and targeted derivatives will be undertaken using novel photocatalyst systems. Successful development of the methodology will enable detailed exploration of the translational potential of these novel scaffolds. The planned studies are relevant to public health in that they will enable preclinical development of novel classes of anticancer and antiviral agents.

PI_NAMEs: PORCO, JOHN A. (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: academic preparation;Advisory Committees;Aglaia;Ally;American;anti-cancer;Anti-Inflammatory Agents;Anti-viral Agents;Area;Biological;career;career development;chemical synthesis;Chemicals;Colombian;community college;Complex;computer studies;Development;Development Plans;Educational workshop;Elements;Evaluation;experience;Exposure to;Goals;Grant;Health;Human Resources;interest;Latino;Mediating;member;Mentors;Mentorship;Methodology;Natural Products;Nicaraguan;novel;Pharmaceutical Chemistry;Plants;preclinical development;Preparation;programs;Protons;Public Health;Publications;Research;Research Personnel;Safety;scaffold;skills training;Students;symposium;Synthesis Chemistry;System;Time;Training;translational potential;Translational Research;translational study;undergraduate student;Viral Physiology;Writing

PROJECT_TITLE: Chemical Synthesis of Complex Natural Products for Translational Science


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Intracellular signaling is critical to many physiological processes, including cell proliferation, growth, development, motility, and stress responses. Also, altered signaling is associated with various diseases. The proposed studies will significantly advance our understanding of the mechanism of intracellular signal transduction and promote the development of therapeutic interventions for human disorders.

PI_NAMEs: IIJIMA, MIHO  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Bar Codes;Binding;biological adaptation to stress;Biosensor;Bypass;cell motility;Cell Nucleus;Cell Proliferation;Cell Reprogramming;Cells;Chemicals;Chemotaxis;CRISPR screen;Development;Dictyostelium;Disease;DNA Repair;Elements;Environment;Epidermal Growth Factor Receptor;extracellular;Genome;genome-wide;Genotoxic Stress;Growth;Guanosine Triphosphate Phosphohydrolases;Human;Immune response;innovation;Knowledge;Mechanical Stress;Monomeric GTP-Binding Proteins;Motility;Neurons;novel;Outcome;Oxidative Stress;Physiological Processes;Physiology;Process;programs;Protein-Serine-Threonine Kinases;PTEN gene;Regulation;Research;response;rho GTP-Binding Proteins;Serine;Signal Transduction;Signal Transduction Pathway;Stress;support tools;Technology;Testing;therapeutic development;Therapeutic Intervention;Tissues;Tyrosine Kinase Receptor Inhibition;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;wound healing

PROJECT_TITLE: Regulation of Intracellular Signaling

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Project narrative The study will delineate gut microbiome translocation to adipose tissues in the regulation of cellular senescence and macrophage function in aged mice undergoing a high-fat diet and intermittent fasting diet. The project will uncover a novel mechanism by which the gut microbiome influences senescence and thus advance the understanding of the complex biology of aging.

PI_NAMEs: XU, MING ;ZHOU, YANJIAO  (contact)

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TERMS: Adipocytes;Adipose tissue;Affect;age related;age-related disease;Aging;Biology of Aging;career;Cell Aging;cell growth regulation;Complex;Diet;dysbiosis;Elderly;Grant;gut microbiome;hallmarks of aging;High Fat Diet;Immunologist;Immunology;in vitro Assay;in vivo;Intermittent fasting;Macrophage;Metabolic dysfunction;microbial;microbiome;microbiome composition;microbiota;Molecular;novel;old mice;parent grant;Parents;Pattern;Phenotype;Prevention;Research;senescence;single-cell RNA sequencing;Testing;Training;Visceral;Visceral fat;Work

PROJECT_TITLE: Reciprocal Modulation of the Microbiome and Cellular Senescence in Metabolic Dysfunction


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This research will produce a culturally sensitive technology-based HIV prevention intervention for Black women in SUD treatment that is aligned with modern prevention efforts, is informed by intersectionality, and circumvents SUD treatment-related barriers. Results of the current study will be impactful in addressing HIV risk among Black substance using women by 1) providing information about social determinants that are associated with HIV risk behaviors, 2) deepening the understanding of HIV risk behavior and current gaps in HIV treatment and 3) supporting the development of a technology-based HIV prevention intervention that is culturally sensitive and can be integrated into SUD treatment settings.

PI_NAMEs: MCCUISTIAN, CARAVELLA  (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Address;AIDS prevention;Area;Attention;Black race;black women;California;career;Clinical Trials Design;Clinical Trials Network;Communities;Complement;condoms;Data;design;Development;Diagnosis;Disparity;Educational Status;Effectiveness;Employment;Epidemic;ethnic minority;experience;Feedback;Female;Gender;Goals;Grant;Health behavior change;Health Personnel;Heterosexuals;HIV;HIV Infections;HIV risk;HIV/AIDS;improved;Infection;intersectionality;Intervention;Interview;K-Series Research Career Programs;Knowledge;lens;marginalization;meetings;member;Mental Health;Mentors;Mentorship;Methodology;Methods;mobile application;Modeling;Modernization;National Institute of Drug Abuse;Participant;patient oriented;Pattern;Persons;Population;Prevalence;Prevention;preventive intervention;psychologic;Psychological Factors;Race;racial health disparity;racial minority;racism;Recording of previous events;Reporting;Research;Research Methodology;Research Personnel;response;Risk;Risk Behaviors;Safe Sex;San Francisco;sex;Sex Behavior;Sexism;Sexual Partners;sexual risk behavior;sexual risk reduction;skills;social determinants;social expectations;social health determinants;social stigma;Strategic Planning;substance use;Substance Use Disorder;System;Technology;technology development;technology intervention;Testing;therapy development;Time;Training;Training Activity;Treatment Efficacy;Universities;Unsafe Sex;Videoconferencing;Woman;Writing

PROJECT_TITLE: Development of a Technology-Based HIV Prevention Intervention for Black Women Who Use Substances

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Infectious Diseases;Lung;Sleep Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Sleep disorders such as obstructive sleep apnea and insufficient sleep are extremely common in people with HIV and are associated with a greater risk of developing heart disease. Sleep disorders can cause monocyte activation in people without HIV, and this effect may be even greater in people with HIV who are already predisposed to monocyte dysfunction. This proposal will test whether sleep disorders alter monocytes in people living with HIV and provide crucial training for the applicant to become an independent scientist focused on understanding how sleep affects immune function and inflammation in people living with HIV infection.

PI_NAMEs: BORKER, PRIYA VASSANT (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Acute;Adhesions;Affect;Aftercare;antiretroviral therapy;Biological;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career development;Cause of Death;CD14 gene;Cell Adhesion;Cell Adhesion Molecules;cell motility;Chronic;Chronic Disease;Clinical;Computational Biology;Continuous Positive Airway Pressure;cytokine;Development;Development Plans;didactic education;dimensional analysis;Elements;Enrollment;Environment;Event;Evolution;Exhibits;experience;experimental study;Exposure to;FCGR3B gene;Frequencies;Functional disorder;Future;Gene Expression;General Population;Health;Heart Diseases;high risk;HIV;HIV Infections;Hour;human subject;Hypoxia;immune function;Immune System Diseases;Immunology;Immunophenotyping;improved;Individual;Inflammation;Inflammatory;Inflammatory Response;Intervention;Knowledge;Measures;Medicine;Mentorship;migration;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;novel;novel strategies;Obstructive Sleep Apnea;Outcome;Pathway interactions;Patients;Persons;pharmacologic;Phenotype;Physicians;Positioning Attribute;Production;prospective;Protocols documentation;Research;research and development;Resources;response;Risk;Sampling;Scientist;screening;Signal Pathway;skills;Sleep;Sleep Deprivation;Sleep Disorders;sleep health;Stimulus;Stress;Subgroup;System;Testing;Therapeutic Intervention;Tissues;Training;transcription factor;transcriptomics;treatment response;Universities;Up-Regulation;Work

PROJECT_TITLE: Understanding the association of sleep on monocyte action in HIV infection


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Microbiome

ORG_DEPT: VETERINARY SCIENCES

PHR: Fungal drug resistance is an emerging threat to public health and especially immunocompromised individuals. The proposed research will examine fungal species and their genes driving resistance in the oral environment of HIV patients with a long-term goal of improved diagnostics to optimize treatment. The project is relevant to the NIH mission in its combination of fundamental biological research on molecular mechanisms of drug resistance with application to enhance human health.

PI_NAMEs: GOODMAN, LAURA BRUNENGRABER (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Antimicrobial Resistance;Automobile Driving;Bacteria;biological research;biomarker identification;Biotinylation;Candida;Candidiasis;Case/Control Studies;Cell Physiology;Clinical;Clinical Microbiology;cohort;Collection;commensal bacteria;Cryopreservation;Data;deep sequencing;Dental caries;Dental Plaque;design;Development;Diagnostic;diagnostic tool;Disease;Drug resistance;dysbiosis;Environment;Epithelial Cells;Evolution;flexibility;Funding;Fungal Drug Resistance;fungal genetics;fungus;Generations;Genes;Genome;Genomic approach;Genomics;Goals;Grant;Growth;Health;Highly Active Antiretroviral Therapy;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV/AIDS;Human;Immunocompromised Host;immunodeficiency;Impairment;improved;Individual;insight;Laboratories;Length;member;Methods;Microbial Biofilms;microbiome;Mission;Modernization;Molecular;molecular diagnostics;molecular marker;Mouth Diseases;Mucous Membrane;Mutation;mycobiome;Mycoses;National Institute of Dental and Craniofacial Research;novel;Oral;oral fungal;oral HIV;oral infection;oral microbiome;Outcome;pathogen;Patient Selection;Patients;Persons;Pharmaceutical Preparations;phenotypic data;Plants;polymicrobial biofilm;pressure;Process;programs;Public Health;Reporting;Research;Research Personnel;Resistance;resistance gene;resistance mechanism;resistome;Resolution;Risk;rRNA Operon;Saliva;saliva sample;Sampling;Sequence Analysis;Signal Transduction;Site;Structure;Swab;Taxonomy;Techniques;Technology;Testing;Time;Time Study;treatment optimization;United States National Institutes of Health;Variant;whole genome;Work

PROJECT_TITLE: Development of antifungal drug resistance in the oral environment over the course of HIV infection


ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project Narrative: Novel and highly efficient synthetic methods developed in this proposal could be applied in and/or facilitate the preparation of bioactive compounds either as small molecular probes for elucidating medically relevant biological pathways or as drug candidates for disease management.

PI_NAMEs: ZHANG, LIMING  (contact)

PROJECT_TITLE: Research Supplements to Promote Diversity in Health-Related Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative: Defects in intracellular transport processes, including mutations in kinesin and dynein motor proteins, are known to contribute to neurodegenerative diseases, cancer, and ciliopathies. This work will utilize biophysical and cell biological approaches to reveal basic information about how kinesin motor proteins function within the complex cellular environment. This work will advance our understanding of intracellular trafficking processes and impact our ability to treat human disease.

PI_NAMEs: VERHEY, KRISTEN J. (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Address;Adopted;Biochemical;Biological;Biophysics;Cells;Cellular Assay;Cellular biology;ciliopathy;Complex;Defect;developmental disease;Disease;Dynein ATPase;Environment;Eukaryotic Cell;Goals;human disease;Intracellular Transport;Kinesin;Link;Malignant Neoplasms;Mammalian Cell;mechanical force;Mechanics;Methods;Microtubule-Associated Proteins;Microtubules;Molecular Motors;Morphology;Motility;Motor;Mutation;Neurodegenerative Disorders;Post-Translational Protein Processing;Process;Property;protein function;Proteins;Recycling;Regulation;Reporting;trafficking;Transport Process;Tubulin;Work

PROJECT_TITLE: Kinesin Motors and Microtubule-based Trafficking

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative This dissertation proposal focuses on the unique needs of cisgender Black women in the United States, a vulnerable population facing disproportionately high rates of HIV and sexually transmitted infections (STIs). Current research is scarce on the complex interplay between sexual reproductive health (SRH) disparities and structural and social determinants of health among this population at risk for HIV in Maryland, particularly in understanding how to effectively integrate HIV prevention into existing SRH services despite these services being a primary and optimal mode for navigating the HIV prevention care continuum. Utilizing a mixed-method approach, this study investigates the availability, accessibility, and acceptability of SRH services, as well as personal experiences and perspectives, to inform the development of contextually appropriate and culturally sensitive HIV prevention strategies that address the root causes of these disparities.

PI_NAMEs: DUROSEAU, BRENICE  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Address;AIDS prevention;American;Baltimore;Behavior Therapy;Biological;Black race;black women;Cause of Death;Chlamydia;cisgender;Cities;Clinical;Complex;Continuity of Patient Care;County;Data Collection;Decision Making;Dedications;design;Development;Discrimination;Disparity;disparity reduction;Distal;Eligibility Determination;Ensure;Epidemic;Evaluation;evidence based guidelines;Exhibits;experience;Face;Female;Gonorrhea;Haitian;health care availability;health care service;health care service utilization;health disparity;Health Promotion;high risk population;High Risk Woman;HIV;HIV diagnosis;HIV disparities;HIV Infections;HIV risk;Human immunodeficiency virus test;implicit bias;improved;Incidence;Individual;insight;Intervention;Interview;lifetime risk;marginalization;Maryland;Methods;Modeling;National Institute of Mental Health;neglect;novel;Outcome;Participant;Population;Populations at Risk;pre-exposure prophylaxis;Prevention;Prevention approach;Prevention strategy;preventive intervention;Preventive measure;Proliferating;Public Health;racial disparity;racial population;racism;reproductive health intervention;Reproductive Health Services;Research;Research Personnel;Research Priority;risk perception;Service provision;Services;Sexism;sexual and reproductive health;Sexual Health;Sexually Transmitted Diseases;Shoulder;social;social determinants;social health determinants;social stigma;statistics;structural determinants;structural health determinants;Structure;Surveys;Syphilis;Testing;theories;therapy development;trend;United States;uptake;virtual;Virus Diseases;Vulnerable Populations;Woman;Women's Group

PROJECT_TITLE: Reimagining HIV Prevention: Unveiling Opportunities to Strengthen Sexual Reproductive Health Services and Promote HIV Prevention among Cisgender Black Women at risk for HIV in Maryland

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17B-W (20)]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

PHR: Project Narrative Hepatitis B virus (HBV) infects >300 million people worldwide, is the leading cause of liver-related death, is worsened by HIV, and is very difficult to cure. We have evidence that HBV-infected people who are receiving treatment show diminished expression of HBV genes, which is an unexpected observation. We propose using new techniques to uncover how diminished expression happens and comparing this process in people with only HBV to those with HIV and HBV.

PI_NAMEs: BALAGOPAL, ASHWIN  (contact);THIO, CHLOE L

PROJECT_TERMS: Affect;analog;Anti-Retroviral Agents;ATAC-seq;Binding;Biological Assay;Candidate Disease Gene;Cause of Death;CD4 Positive T Lymphocytes;cDNA Library;Cell Count;Cells;Cessation of life;Characteristics;Chromatin;chromatin immunoprecipitation;Chronic;Chronic Hepatitis B;Circular DNA;circular RNA;Clinical;Co-Immunoprecipitations;co-infection;Complementary DNA;CRISPR/Cas technology;Cytoplasm;Data;differential expression;digital;Disease Outcome;end stage liver disease;Epigenetic Process;Gene Expression Profiling;Gene Silencing;Genes;Genetic Transcription;Goals;Hepatitis;Hepatitis B;Hepatitis B Therapy;Hepatitis B Virus;Hepatocyte;HepG2;Histone Deacetylase Inhibitor;histone modification;Histones;HIV;Human;immune activation;In Vitro;in vitro testing;indexing;Individual;Infection;interest;Interruption;intrahepatic;Knock-out;Knowledge;laser capture microdissection;Liver;Liver diseases;Measurable;Measures;Messenger RNA;Methods;Methylation;Methyltransferase;Modeling;Modification;Molecular;multidisciplinary;nanopore;novel;overexpression;Pathway interactions;Persons;Plasma;Primary carcinoma of the liver cells;Process;Resolution;Reverse Transcription;Reverse Transcription Inhibition;RNA;RNA Splicing;Sampling;T-Cell Depletion;Testing;therapy development;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;Transferase;Use of New Techniques;Variant;Viral;viral DNA;Viral hepatitis;Viral Proteins;viral rebound;viral RNA;Virion;Virus Diseases;Virus Replication

PROJECT_TITLE: HBV cccDNA transcriptional silencing with and without HIV


NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project narrative This proposal represents a Supplement to Promote Diversity for a Hispanic graduate student to conduct research related to the parent RM1 (GM142002), expanding the scope of our existing aims. Mr. Max Balderas is a student in Joseph Ready’s research group, and he will develop chemical degraders of the enzyme 15- PGDH. The proposed research will advance our understanding of the role and regulation of 15-PGDH while integrating Mr. Balderas into a collaborative multi-disciplinary research program.

PI_NAMEs: MARKOWITZ, SANFORD D.;PIEPER, ANDREW A;READY, JOSEPH M (contact);TAYLOR, DEREK JAMES

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Binding;Biochemistry;Biology;career;Cells;Cellular biology;Chemicals;Complex;Dinoprostone;Disease;disease model;Drug Targeting;Enzymes;experimental study;Exposure to;Foundations;graduate student;Grant;Growth;Hispanic Graduate Student;in vivo;Inflammation;Inflammatory Bowel Diseases;inhibitor;Interdisciplinary Study;Kidney Diseases;multicatalytic endopeptidase complex;Nerve Degeneration;Neurosciences;Organ;Oxidoreductase;Parents;Pathway interactions;Pattern;Pharmaceutical Chemistry;Pharmacology;Pharmacotherapy;prevent;programs;Prostaglandins;Protein Biosynthesis;Proteins;Pulmonary Fibrosis;Reagent;recruit;Regulation;Research;Research Project Grants;response;Rodent Model;Role;Signal Pathway;Signal Transduction;small molecule inhibitor;structural biology;Students;Synthesis Chemistry;three dimensional structure;tissue regeneration;tissue repair;Tissues;tool;Training;Trauma;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Chemical, Structural and Cell-Signaling Interrogation of 15-Prostanglandin Dehydrogenase in Tissue Repair and Regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


ORG_CITY: CLEVELAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The pentameric ligand-gated ion channels (pLGIC) mediate fast synaptic transmission in the central and peripheral nervous systems, and thereby critically govern numerous cellular processes such as pain perception, motor coordination, and gastrointestinal functions. Dysfunctions in pLGIC are associated with several psychiatric, neurological, and gastrointestinal disorders, and therefore these channels are important drug targets. The goal of the proposed studies is to elucidate fundamental mechanisms governing channel function and modulation at a molecular level. Findings from this work will lead to a better understanding of the role of pLGIC in various physiological and pathophysiological processes, and hence aid strategies for development of new and safer therapeutics.

PI_NAMEs: CHAKRAPANI, SUDHA  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: addiction;Binding;Binding Proteins;Biochemical;Cell Physiology;Central Nervous System;chronic pain;Complex;Cryoelectron Microscopy;design;Development;Drug Targeting;Electrophysiology (science);Environment;Event;Functional disorder;Gastrointestinal Diseases;gastrointestinal function;Glycine Receptors;Goals;HTR3A gene;Ion Channel Gating;Knowledge;Length;Ligands;Lipids;Malignant Neoplasms;Mediating;Membrane;Membrane Lipids;Mental disorders;Molecular;Molecular Conformation;Mood Disorders;Motor;multidisciplinary;Nervous System Disorder;novel therapeutics;Pain;pain perception;particle;Peripheral Nervous System;Physiologic pulse;Physiological;Physiological Processes;Process;Protein Dynamics;receptor;Resolution;Rest;Role;Serotonin;serotonin receptor;Signal Transduction;Structure;Synaptic Transmission;Techniques;Therapeutic;Therapeutic Agents;therapeutic target;Therapeutic Uses;transmission process;Work

PROJECT_TITLE: Structure and Function of Pentameric Ligand-Gated Ion Channels


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Lung

ORG_CITY: LUBBOCK

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: NARRATIVE The presence of Human Immunodeficiency Virus (HIV) in the cells of the infected people limits the development of an effective cure to this infection. These cells or organs where the virus persists are called “HIV reservoirs” and scientists are still working to keep discovering new HIV reservoirs that may need study. We propose experiments to investigate a cell type that is in the blood vessels of the lungs as potential cells acting as viral reservoirs.

PI_NAMEs: ALMODOVAR, SHARILYN  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acute;Anatomy;antiretroviral therapy;Apoptosis;Archives;Automobile Driving;Autophagocytosis;Biological Assay;Blood Vessels;CD34 gene;Cell Aging;Cell Death Induction;cell type;Cells;Characteristics;Chronic;Coculture Techniques;Collection;comorbidity;Cytoprotection;Data;Development;Disease;DNA;Drug resistance;DsRed;Endothelial Cells;Engraftment;Ensure;Enzyme-Linked Immunosorbent Assay;Experimental Designs;experimental study;Face;Foundations;Genetic Transcription;HIV;HIV Infections;Human;humanized mouse;Immune;Immune system;Immunohistochemistry;Immunological Models;Implant;In Vitro;in vitro Model;in vivo;in vivo Model;Infection;insight;Interruption;Label;Literature;Location;Lung;Lung infections;Measures;Mediating;Modeling;molecular marker;Monitor;Mus;nonhuman primate;novel;Organ;particle;Patients;Persons;Plasma;Predisposition;Proliferating;Proteins;Public Health;pulmonary vascular cells;pulmonary vasoconstriction;Quantitative Reverse Transcriptase PCR;receptor expression;Research;resilience;Resistance;Sampling;Scientist;Signal Pathway;Signal Transduction;SIV;Smooth Muscle Myocytes;Source;Structure of parenchyma of lung;success;Supporting Cell;T-Lymphocyte;Testing;Tissue Sample;Tissues;Transplantation;Variant;Vascular Smooth Muscle;vasoconstriction;Viral;viral DNA;Viral Genes;Viral Load result;Viral reservoir;Viremia;Virion;Virus;Virus Replication;Virus Shedding;Work

PROJECT_TITLE: Investigating Novel HIV Reservoirs in the Pulmonary Vasculature

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Orphan Drug;Patient Safety;Prevention;Rare Diseases

ORG_CITY: Mansfield

ORG_NAME: PHAGEPRO, INC.

PHR: Project Narrative This proposal aims to plan the first-in-human Phase I/II clinical trial of a phage-based clinical intervention, ProphaLytic-VcTM (PVC), to prevent the community spread of cholera in Dhaka, Bangladesh. With the successful completion of prior small business grants, PhagePro has demonstrated that PVC is highly effective in preventing Vibrio cholerae colonization of the small intestine in mice and rabbits, thus protecting against cholera. We have established robust small-scale phage manufacturing parameters, optimized critical quality control assays, constructed an avirulent V. cholerae manufacturing strain, and completed Investigational New Drug (IND)- enabling studies aligned with the FDA’s expectations for phage products. With Serán Bioscience, we have optimized small-scale processes for solid dosage formulation of each PVC phage. With this R34 clinical trial planning proposal, we aim to collaborate with cholera physicians and researchers at the International Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b) to develop documentation to support successful implementation of the Phase I/II trial for safety and efficacy of PVC in household contacts of cholera patients. In addition, we will develop a regulatory plan in alignment with Bangladeshi authorities and the U.S. Food and Drug Administration. If successful, the clinical trial will demonstrate proof-of-clinical efficacy for PVC and the potential for PVC to be a transformative tool in controlling cholera outbreaks around the world.

PI_NAMEs: CAMILLI, ANDREW ;YEN, MINMIN  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Adult;Advisory Committees;Africa;Antibiotics;arm;authority;Bacteria;Bacteriophages;Bangladesh;Bangladeshi;Biological Assay;Biological Sciences;Blood Chemical Analysis;Businesses;Cessation of life;Cholera;Cholera Vaccine;Clinical;clinical efficacy;Clinical Protocols;Clinical Research;clinical trial protocol;Clinical Trials;Clinical Trials Data Monitoring Committees;Cold Chains;Collaborations;Communities;community transmission;contaminated water;Contracts;Country;data management;design;Detection;Development Plans;Diarrhea;diarrheal disease;Disease;Disease Outbreaks;Documentation;dosage;Dose;efficacy trial;Enrollment;Ensure;Environment;Epidemic;Ethics;expectation;Family Leave;fecal microbiome;Feces;Feedback;first-in-human;Formulation;Geographic Locations;Geography;Goals;Grant;gut microbiome;Health;healthy volunteer;Hour;Household;Hygiene;Incidence;indexing;Institutional Review Boards;international center;Intervention;Investigational Drugs;Investments;Manuals;manufacture;Measures;Medical Research;Methodology;Methods;Monitor;Multi-Drug Resistance;Mus;operation;Oral;Oral Administration;Oryctolagus cuniculus;Pamphlets;pathogen;Patients;Persons;Pharmaceutical Preparations;Pharmacists;Phase;Phase I/II Clinical Trial;Phase I/II Trial;phase III trial;Physicians;Placebos;Plaque Assay;Population;Populations at Risk;Preparation;prevent;Prevention;Preventive;primary endpoint;Procedures;Process;Prophylactic treatment;Quality Control;Randomized;rapid test;recruit;Reporting;Research;Research Ethics Committees;Research Personnel;Resistance;Resources;Review Committee;Risk;Safety;Sanitation;secondary endpoint;Secondary to;Self Administration;Shotgun Sequencing;Site;Small Intestines;Solid;Source;Specialist;success;Symptoms;Testing;Time;tool;transmission process;trial design;trial planning;United States Food and Drug Administration;Vibrio cholerae;volunteer;Water;World Health Organization

PROJECT_TITLE: Preparation of a Phase I/II safety and efficacy trial for a cholera phage cocktail intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SA-M (J1)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE Environmental Health Sciences (EHS) encompasses many fields of study that seek to understand how chemicals in the environment impact human health. We plan to improve the interoperability, machine accessibility, and understandability of EHS data by identifying EHS community needs, expanding existing data standards, and developing testable workflows. Our overall objective is to develop standards and tools that allow the integration of data from all EHS fields to support public health and safety assessments.

PI_NAMEs: HINES, DAVID  (contact)

PROGRAM_OFFICER_NAME: DUNCAN, CHRISTOPHER GENTRY

PROJECT_TERMS: Address;Adverse effects;adverse outcome;Aloral;Area;Biochemical;Biological;Biological Markers;Biological Process;Chemicals;Chronic Obstructive Pulmonary Disease;Communication;Communities;community engagement;Computer Models;Computers;Data;data acquisition;data exchange;data integration;data interoperability;data standards;data translator;Development;Discipline;dosimetry;Educational workshop;Ensure;Environment;environmental change;Environmental Exposure;Environmental Health;Environmental Impact;Event;exposed human population;exposure pathway;Exposure to;Feedback;field study;fine particles;Future;Goals;Health;health assessment;Human;human model;improved;insight;interoperability;Knowledge;Language;Link;Measurement;meetings;member;Metadata;metadata standards;Modeling;National Center for Advancing Translational Sciences;Ontology;Outcome;outcome prediction;Particulate Matter;Pathway interactions;Phase;physical process;Population;Process;Public Health;Research;safety assessment;Science;Semantics;Series;simulation;Source;Standardization;System;Terminology;Testing;Time;tool;Toxic effect;Work

PROJECT_TITLE: Data Standards to Support Integrated Source to Outcome Modeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-D (HS)]


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE A globally effective HIV-1 vaccine will elicit diverse immune responses, including broadly neutralizing antibodies. Our proposed studies are relevant to the development of such a vaccine, as we aim to elicit such antibodies through a guided immunization protocol.

PI_NAMEs: STAMATATOS, LEONIDAS  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Acceleration;Adjuvant;Affect;Antibodies;Antibody Binding Sites;Antibody Response;Antigens;B cell repertoire;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Binding Sites;Data;design;Development;Elements;Frequencies;Generations;Genes;Germ Lines;Growth;HIV;HIV-1;HIV-1 vaccine;Human;Immune response;Immunization;Immunologics;improved;in vivo;Infection;Knock-in Mouse;Lead;Light;lonely individuals;Messenger RNA;Methodology;mouse model;Mus;Mutation;neutralizing antibody;Pathway interactions;Production;Proteins;Protocols documentation;Recombinant Proteins;Reporting;response;Surface;Transgenic Mice;Vaccines;Viral;Virus;virus testing;Work

PROJECT_TITLE: Guiding the maturation of anti-CD4-BS bnAbs through sequential heterologous Env immunization

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE We think that aging causes cells in the bone marrow to stop secreting proteins that support normal development of immune cells, the cells in the body that heal wounds. This causes abnormal immune cells to travel to the arteries and cause disease. In this project, we will reverse aging in the bone marrow and see if it can prevent disease in the arteries.

PI_NAMEs: CHAN, CHARLES KF;NGUYEN, PATRICIA KIM PHUONG (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: 6 year old;Adult;Affect;age effect;age related;age related changes;aged;Aging;aging reversal;Animal Model;Area;Arteries;Atherosclerosis;Basic Science;Biological Assay;Blood Vessels;BMP2 gene;Body System;bone aging;Bone Marrow;career;Cell Differentiation process;Cell Transplantation;Cells;Cellular Assay;Cessation of life;Child;chronic inflammatory disease;control trial;cytokine;Data;Development;disadvantaged background;Disease;Environment;Equilibrium;experimental study;Exposure to;Fatty acid glycerol esters;feeding;Food;functional improvement;Funding;genomic signature;Goals;Government;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;High Fat Diet;Histology;Homelessness;Human;human tissue;Hydrogels;Immune;Immune system;In Vitro;Individual;Inflammaging;Infusion procedures;Learning;Left;life span;Low-Density Lipoproteins;Measures;Microscopy;migration;multidisciplinary;Mus;Myelogenous;Myocardial Infarction;Myocardial Ischemia;novel strategies;novel therapeutics;old mice;older patient;Organ;Outcome;Patients;Pattern;Phagocytosis;Physicians;Placebos;prevent;Productivity;Protein Secretion;proteomic signature;Randomized;Refugee Camp;Refugees;Rejuvenation;Reporter;Research;Research Personnel;response to injury;Risk;RNA;Scientist;Signal Transduction;skeletal stem cell;Societies;Stains;stem cell aging;Stroke;success;System;Techniques;Testing;therapeutic target;Tissue Harvesting;Translational Research;Transplantation;Travel;uptake;Vascular blood supply;Vascular Diseases;vascular inflammation;Vietnam;War;western diet;Work;wound healing

PROJECT_TITLE: Organ system cross talk in ischemic heart disease

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]