NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Obesity;Pediatric;Prevention;Sleep Research

PI_NAMEs: WOOD, ALEXIS CAROLINE (contact)

PROJECT_TERMS: 4 year old;5 year old;Academic achievement;Accounting;Adverse effects;age group;Area;Assessment tool;Attitude;Behavior;Body mass index;Buffers;Caregivers;cascade genetic testing;Cellular Phone;Characteristics;Child;Child Development;Child Health;Child Rearing;Childhood;Clinical Psychology;Code;Cognition;Cognitive;cognitive ability;cognitive process;cohort;Complex;Country;COVID-19 pandemic;Data;Development;developmental psychology;Devices;digital;digital media;digital technology;Distance Learning;Education;Electrical Engineering;emotion regulation;executive function;experience;follow-up;Goals;Guidelines;handheld mobile device;Health;Health Services;high body mass index;Home;Hour;improved;innovation;interdisciplinary approach;Investigation;Light;Link;Literature;longitudinal design;Longitudinal Studies;Measures;media use;Medial;Mediating;Methods;Modeling;Monitor;multitask;Nature;new technology;North America;novel;Nursery Schools;Obesity;obesity risk;Occupational;Outcome;pandemic disease;Parent-Child Relations;Parents;Pathway interactions;Pediatrics;peer;portability;Preschool Child;Procedures;programs;Public Health;Recommendation;Reporting;Research;Research Design;Research Support;Role;scaffold;School-Age Population;sedentary;service providers;Short-Term Memory;Sleep;Structure;Technology;Technology Assessment;Testing;Time;Weight;Youth

PROJECT_TITLE: Longitudinal associations of preschoolers' technology and digital medial (TDM) use and executive functioning: a mechanism linking TDM with young children's weight status


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Fused in sarcoma (FUS) is an RNA binding protein that can form biomolecular condensates via liquid-liquid phase separation. Aberrant FUS condensates can seed pathogenic aggregation that leads to neurodegenerative diseases, ALS and FTD. Based on our recent finding that the RNA helicase DDX6 regulates FUS condensation in cells, I propose to apply a combination of single molecule, biochemical, and cell-based methods to determine the effect of DDX6 on wildtype and ALS/FTD-linked FUS mutant activity. Understanding the molecular mechanism behind FUS granule maintenance could help illuminate ALS/FTD pathogenesis and possibly lead to new routes of ALS/FTLD treatment.

PI_NAMEs: MEKONNEN, GEMECHU  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Adsorption;Affect;Amyotrophic Lateral Sclerosis;ATP Hydrolysis;ATP phosphohydrolase;Binding;Biochemical;Biological Assay;Biophysics;Caenorhabditis elegans;Cell Line;Cells;Cellular Stress;Complex;CRISPR/Cas technology;Cytoplasm;Cytoplasmic Granules;cytotoxic;Defect;Dependence;Disease;Emulsions;Exhibits;experience;experimental study;fluidity;frontotemporal lobar dementia amyotrophic lateral sclerosis;fused in sarcoma;Genetic Screening;Growth;helicase;Homeostasis;Human;In Vitro;Inclusion Bodies;knock-down;Lead;Link;Liquid substance;Maintenance;Measures;Methods;Molecular;mutant;Mutation;neuroblastoma cell;Neurodegenerative Disorders;Nuclear RNA;overexpression;particle;Pathogenesis;Pathogenicity;PDAP2 Gene;Phase;Physical condensation;Play;prevent;Property;Proteins;Regulation;response;reverse genetics;Ribonucleoproteins;RNA;RNA Helicase;RNA Probes;RNA-Binding Proteins;Role;Rotation;Route;single molecule;small hairpin RNA;Solid;Stimulus;Stress;stress granule;Structure;superresolution microscopy;Surface;Testing;Time;Work

PROJECT_TITLE: Defining the Role of DDX6 in Regulating FUS Condensates


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric;Sleep Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PI_NAMEs: MORENO, JENNETTE P (contact)

PROJECT_TERMS: 4 year old;Academic achievement;actigraphy;Acute;Address;Adult;Affect;Anxiety;assessment application;Attenuated;Beds;Brain;Child;child depression;Childhood;circadian;circadian pacemaker;Circadian Rhythms;Communication;Cues;Devices;digital media;Drowsiness;Environment;Executive Dysfunction;executive function;experimental study;Exposure to;Eye;falls;Feeling;Future;Goals;Guidelines;handheld mobile device;high risk;Home;Home environment;hormonal signals;Hour;Household;innovation;Intervention;Knowledge;Laboratories;Light;light emission;Lighting;Link;Literature;media use;Melatonin;Methods;novel;obesity development;pandemic disease;Parents;Pattern;Performance;Phase;Physiology;poor sleep;prevent;Randomized, Controlled Trials;Reader;Recommendation;REM Sleep;Research;Research Methodology;Risk;risk mitigation;Role;Short-Term Memory;Signal Transduction;Sleep;sleep behavior;Sleep Disorders;sleep onset;sleep quality;Source;Stimulus;System;Tablet Computer;Tablets;Technology;Technology Assessment;Testing;Time;Translating;Weight

PROJECT_TITLE: Experimental effects of children's evening media use on circadian phase, sleep, and executive functioning


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Schizophrenia is a chronic and disabling psychiatric disorder, with modestly effective available treatments, and poorly understood brain mechanisms. Since the visual system is one of the most extensively studied neural systems in basic neuroscience, this study aims to understand the neural mechanisms of the visual impairments in schizophrenia, through behavioral experiments, computer simulations of the neural networks, and neuroimaging. Such a mechanistic understanding of schizophrenia could lead to novel targets for therapeutic interventions and potentially yield objective biomarkers of response to treatment and facilitate early detection strategies.

PI_NAMEs: BABADI, BAKTASH  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Affect;Area;area striata;Behavioral;behavioral response;Biological Markers;biophysical model;Biophysics;Brain;brain dysfunction;career;Chronic;Clinical;Clinical Research;Cognitive deficits;Compensation;Complex;computational neuroscience;Computer Models;Computer Simulation;contrast enhanced;Country;deep learning;Depth Perception;Detection;Development;Disabling;Disease;Disparity;Early Diagnosis;experimental study;extrastriate visual cortex;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;Human;Impairment;improved;Individual;information processing;Lateral Geniculate Body;Link;Measures;Mental disorders;Mentored Patient-Oriented Research Career Development Award;Mentorship;Modeling;Molecular Abnormality;Nature;neural;neural correlate;Neural Network Simulation;neuroimaging;neuromechanism;Neuronal Dysfunction;Neurosciences;new therapeutic target;novel therapeutics;orientation columns;Patients;Performance;Persons;Process;Psychiatrist;Psychiatry;Psychophysics;Quality of life;Reporting;Research;Resolution;response;response biomarker;Retina;Schizophrenia;Series;Signal Transduction;Stimulus;Structure;Symptoms;Synapses;System;Techniques;Testing;Therapeutic Agents;Therapeutic Intervention;Time;Training;Training Programs;treatment response;Visual;Visual Cortex;Visual impairment;visual information;visual neuroscience;Visual Perception;visual processing;Visual Psychophysics;visual stimulus;Visual System

PROJECT_TITLE: Deficits of the Early Visual System in Schizophrenia, a Combined Psychophysical, Computational, and Neuroimaging Approach

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Genetics;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE A remarkable feature of epithelial stem cells is their ability to rapidly detect, respond, and endure environmental perturbations. This project aims to develop an integrative genetic platform to investigate how epithelial stem cells sense and adapt to inflammation by modulating immune cells to rebuild a new niche and by reprograming their metabolism to reduce inflammatory damage. The goal of this project is to understand how these adaptive functions of epithelial stem cells promote successful wound repair.

PI_NAMEs: MIAO, YUXUAN PHOENIX (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Adopted;Affect;Biology;Cells;Chromosome Mapping;CRISPR screen;design;Economics;epithelial stem cell;fitness;Foundations;Future;gene discovery;Genes;Genetic;Goals;Homeostasis;Immune;immune cell infiltrate;immunoregulation;in utero;in vivo;Infection Control;Inflammation;Inflammatory;inflammatory milieu;injury and repair;Investigation;Metabolism;Microinjections;migration;mouse model;Mus;Natural regeneration;non-healing wounds;Organelles;Persons;Play;Poison;Positioning Attribute;prevent;programs;Public Health;rapid detection;Role;self-renewal;sensor;Solid;stem cells;stress tolerance;System;Techniques;Technology;tissue regeneration;Tissues;tool;ultrasound;wound;wound environment;wound healing

PROJECT_TITLE: Genetic mapping of the inflammatory adaption circuit in epithelial stem cells

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Nutrition;Patient Safety;Pediatric;Prevention;Sleep Research

PI_NAMEs: THOMPSON, DEBORAH I (contact)

PROJECT_TERMS: Address;Adverse event;Agreement;Annual Reports;Atmosphere;Businesses;Child;Child Development;Child Health;Child Nutrition;Clinical Trials Data Monitoring Committees;cognitive development;college;Communication;cost effective;Data Security;Development;digital media;Electronics;Ensure;Equity;equity, diversity, and inclusion;executive function;Faculty;Feedback;Goals;Guidelines;Health;Institution;Lead;Leadership;Literature;media use;Medicine;Methods;Mission;Monitor;National Institute of Child Health and Human Development;Nursery Schools;Nutritional Study;Outcome;Participant;Patient Recruitments;pediatric department;Policies;Procedures;Process;programs;Protocols documentation;recruit;Reporting;Research;Risk;risk mitigation;School-Age Population;Secure;Sleep;social media;synergism;System;Technology;Training;United States Department of Agriculture;web site;Weight;Work

PROJECT_TITLE: Administrative Core (A-Core)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative In normal perception, audiovisual interactions can have many beneficial perceptual consequences, including faster reaction times, more accurate judgments, or more rapid learning, while multisensory impairments such as audiovisual speech facilitation are an intermediate phenotype of psychiatric diseases such as schizophrenia and autism. Understanding the circuitry mediating audiovisual influences during early sensory processing is thus likely to lead to improved multisensory learning paradigms, improved neural prosthetics, or improved understanding of the biological bases of neuropsychiatric disorders.

PI_NAMEs: HASENSTAUB, ANDREA RAYNE (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Adaptive Behaviors;Address;Affect;Area;audiovisual speech;Auditory;Auditory area;Auditory system;autism spectrum disorder;awake;base;Behavior;Behavioral;Biological;Brain;cell type;Code;Communication;comparative;Data;experience;experimental study;extrastriate visual cortex;flexibility;Goals;improved;information processing;interdisciplinary approach;Judgment;Learning;Literature;Mediating;Mental disorders;Methods;millisecond;Modality;Modeling;mouse model;multimodality;multisensory;Mus;neural prosthesis;Neurons;neuropsychiatric disorder;optogenetics;Perception;phenomenological models;Phenotype;Photic Stimulation;predictive modeling;Reaction Time;recruit;Research;Resolution;response;Role;Schizophrenia;segregation;Sensory;Sensory impairment;Sensory Physiology;sensory system;Signal Transduction;sound;Stimulus;System;Task Performances;Techniques;Testing;Thalamic structure;Transgenic Mice;virtual;Vision;Visual;Visual Cortex;visual information;Visual System

PROJECT_TITLE: Cortical circuitry supporting flexible audiovisual interactions and behaviors


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Pediatric;Sleep Research

PROJECT_TERMS: Accelerometer;actigraphy;Address;Android;Archives;Beds;Behavior;Child;Child Health;Child Nutrition;circadian;Circadian Rhythms;Code;cohort;Collaborations;Communities;computerized data processing;Consultations;Data;Data Collection;data integration;data quality;Development;Devices;diaries;digital;digital assessment;digital media;elementary school;Ensure;Equipment and supply inventories;Excision;executive function;Funding;Future;Goals;Guidelines;handheld mobile device;Home;Home environment;Hour;Institution;Interdisciplinary Study;junior high school;Learning;Light;Maintenance;Manuals;Measures;media use;member;Metabolic;Methods;Mission;multidisciplinary;Nursery Schools;Nutritional Study;parental role;Parents;Pattern;Play;Polysomnography;Positioning Attribute;Procedures;Process;programs;Quality Control;remote monitoring;Reporting;Research;Research Training;Rest;Sampling;School-Age Population;Secure;sensor;Services;Sleep;software development;Technical Expertise;Techniques;Technology;Technology Assessment;Testing;Training;tv watching;wearable device;Weight;Wrist

PROJECT_TITLE: Digital Assessment Core


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Nutrition;Obesity;Pediatric;Prevention;Sleep Research

PI_NAMEs: MUSAAD, SALMA  (contact)

PROJECT_TERMS: Accelerometer;Area;arm;Behavior;Biometry;Biostatistics Core;Child;Child Health;Child Nutrition;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Cognitive;cohort;Collaborations;Collection;college;Communication;cost effectiveness;Data;Data Analyses;data de-identification;Data Element;data exchange;data harmonization;data management;data quality;Data Set;Data Storage and Retrieval;Databases;demographics;design;Development;digital assessment;Doctor of Philosophy;Documentation;Education and Outreach;Electronics;Ensure;Epidemiology;Equation;Evaluation;executive function;experience;Experimental Designs;Floor;Fostering;Gastroparesis;Genetic;Goals;Health;Health Sciences;Housing;Human Resources;Illinois;improved;Individual;Information Dissemination;Intervention;Kidney Diseases;Knowledge;Lead;Longitudinal cohort study;Measures;media use;Medicine;member;Meta-Analysis;Methodology;Methods;Mission;Modeling;Multi-Ethnic Study of Atherosclerosis;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Nutritional Study;Obesity;obesity in children;obesity risk;Observational Study;Outcome;Outcome Measure;pediatric department;Phenols;Physical activity;Preparation;preservation;Procedures;Process;Program Sustainability;programs;Protocols documentation;Psychometrics;quality assurance;Quality Control;Randomized, Controlled Trials;relational database;Research;Research Design;Research Personnel;Resources;Role;Sample Size;Services;Sleep;sound;Specimen;Statistical Data Interpretation;Structure;synergism;System;Universities;vaccine efficacy;Weight;Wood material;Youth

PROJECT_TITLE: Biostatistics and Data Management Core (BDM-Core)


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative This implementation science planning grant aims to elicit preference-driven strategies to tailor contextually appropriate antiretroviral therapy (ART) packages, including long-acting injectables (LAI), for youth living with HIV (YLWH) in South Africa. The design will: (1) leverage the Consolidated Framework for Implementation Research (CFIR) to qualitatively identify implementation barriers and facilitators and inform LAI delivery and messaging; (2) utilize a partial preference trial among YLWH 18-29 years to identify choices and trajectories around early LAI; and (3) conclude with microsimulation model of trial participants to assess the benefits of LAI vs oral ART (pills) for different subgroups of YLWH. Findings will provide clarity around which YLWH may most benefit from LAIs and which strategies should be delivered to those patients in a subsequent sequential multiple assignment randomized trial (SMART) to optimize treatment for YLWH.

PI_NAMEs: ORRELL, CATHERINE ;SCHWARTZ, SHEREE RENAE (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Age;aged;AIDS prevention;antiretroviral therapy;Area;arm;barrier to care;Behavioral;Caring;Childhood;Clinic;Clinical;Clinical Trials;cognitive development;Consolidated Framework for Implementation Research;Country;Data;design;Development;Eastern Africa;Economics;emerging adult;Exclusion;experience;Family member;follow-up;Foundations;future implementation;Generations;Goals;Government;Grant;Health;Health Personnel;HIV;Hour;implementation barriers;implementation facilitators;implementation science;implementation strategy;implementation trial;improved;Individual;Infection;Injectable;Injections;innovation;Interview;marginalization;Modeling;models and simulation;Newly Diagnosed;next generation;Nurses;older adult;Oral;Outcome;Parents;Participant;Patient Preferences;Patients;Pattern;Perinatal;Persons;pill;pilot trial;Population;preference;prevention service;primary endpoint;Professional counselor;programs;Provider;Psychosocial Assessment and Care;Randomized;Recording of previous events;Research;resilience;Resistance;Resource-limited setting;Schedule;Schools;secondary endpoint;Sequential Multiple Assignment Randomized Trial;sex;Sexual Partners;Site;social stigma;South Africa;Southern Africa;Specific qualifier value;structural determinants;Structure;Subgroup;Supervision;testing services;therapy adherence;Time;treatment optimization;Treatment outcome;treatment strategy;trial design;Viral;Viral Load result;Work;young woman;Youth

PROJECT_TITLE: Designing Next Generation Treatment Strategies for Adolescents and Young Adults Living with HIV (The NextGen Study)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-M(53)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Lung;Patient Safety

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: BARRON ASSOCIATES, INC.

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed ROAM system objectively determines the duration and pattern of adherence to oxygen therapy on a minute-by-minute basis and provides feedback of usage metrics to patients and clinicians. The proposed SBIR Phase II research addresses an important public health concern by providing accurate assessment of patient adherence to oxygen therapy and promoting adherence to a treatment that many patients neglect. The ultimate impact will be to improve health outcomes and reduce the costs associated with expensive and preventable hospitalizations due to non-adherence.

PI_NAMEs: KREPKOVICH, EILEEN T. (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Address;Adherence;adherence rate;Algorithms;Attention;Authorization documentation;Breathing;Cannulas;care providers;Certification;Cessation of life;Chronic Obstructive Pulmonary Disease;Classification;classification algorithm;Clinical effectiveness;Clinical Management;Communication;Computer software;cost;dashboard;Data;design;design verification;Detection;Devices;effective therapy;effectiveness outcome;Feedback;Focus Groups;Frequencies;Goals;Health;Health Care Costs;Health Personnel;Health Status;Healthcare Systems;Home;Hospitalization;Hour;Human;Hypoxemia;improved;improved outcome;Inhalation;innovation;Lead;Length of Stay;Link;Measurement;Measures;Methods;Modality;Monitor;mortality;Motivation;neglect;next generation;Nose;novel;optimism;Outcome;Oxygen;Oxygen Therapy Care;Participant;Patient Compliance;patient-clinician communication;Patient-Focused Outcomes;Patients;Pattern;Persons;Phase;pressure;Prevalence;Production;programs;prototype;Provider;provider communication;Public Health;Pulmonary Heart Disease;Pulse Oximetry;Quality of life;Questionnaires;Randomized;Randomized Controlled Clinical Trials;Research;respiratory oxygen;Risk;Safety;sensor;signal processing;Sleep;Small Business Innovation Research Grant;Software Design;Source;Specific qualifier value;success;System;Technology;Testing;therapy adherence;time use;United States;usability;Validation;visual feedback;wireless data transmission

PROJECT_TITLE: Respiratory Oxygen Adherence Monitor for COPD Patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(10)B]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project narrative The rapidly increasing prevalence of type 2 diabetes (T2D) in the US and worldwide represents a public health crisis and a key health disparity. Improved options for T2D prediction, prevention, and treatment are urgently needed. This proposal builds on a longstanding, highly productive collaboration between researchers in the United States, Finland, and around the world. We will discover and fine map genetic loci that influence risk of T2D and variability in T2D-related traits, and identify the causal variants, genes, and other functional units in the genome, and the mechanisms by which they act. Our ultimate goals are disease prevention and treatment.

PI_NAMEs: BOEHNKE, MICHAEL L (contact);SCOTT, LAURA J.

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Acceleration;Achievement;Address;Affect;AKT2 gene;American;base;Base Sequence;Beta Cell;Callback;cardiometabolism;causal variant;Cell Nucleus;cell type;Chromatin;Chromosome Mapping;clinical phenotype;clinical translation;Code;cohort;Collaborations;Computing Methodologies;Data;data sharing;Data Sources;data visualization;database of Genotypes and Phenotypes;Development;Diabetes Mellitus;diabetes mellitus genetics;diabetes risk;disorder prevention;diverse data;DNA Methylation;Environment;Epidemic;Etiology;European;exome;Finland;Fostering;Frequencies;Gene Expression;Genes;Genetic;genetic association;Genetic study;genetic variant;Genome;genome wide association study;genomic locus;Genomics;Genotype;Glucose;Goals;Head;Health Care Costs;health disparity;Heritability;human disease;Human Gene Mapping;human old age (65+);improved;Incidence;Individual;individualized medicine;induced pluripotent stem cell;Insulin Resistance;interest;Investigation;Islets of Langerhans;Knowledge Portal;Lead;Life Style;Maps;Measures;Medical Care Costs;men;Meta-Analysis;Metabolic Diseases;Metabolic syndrome;Methods;Methylation;Michigan;Molecular;molecular phenotype;Morbidity - disease rate;mortality;Muscle;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;open source tool;Organ;Persons;Phenotype;phenotypic data;Physiological;Play;Population;Prevalence;Prevention;Productivity;Public Health;Quantitative Trait Loci;rare variant;Recording of previous events;Research;Research Personnel;Resolution;Resources;Risk;risk prediction;Role;Sample Size;Sampling;sex variable;Signal Transduction;Site;Skeletal Muscle;Statistical Methods;success;targeted treatment;Testing;tool;trait;United States;Variant;Visualization;whole genome;Work

PROJECT_TITLE: Identifying Genes for Type 2 Diabetes: FUSION

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Prevention

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE  Aging is the single most significant risk factor for cancer. Although there are many plausible age-related mechanisms that mediate the increased risk for cancer in the elderly, functional evidence is lacking for the majority of these mechanisms. This proposal will focus on the role of the aged microenvironment, particularly senescence, in promoting the formation of colorectal cancer (CRC), a common age-related cancer in the U.S.  Our group has recently shown that a senescent normal colon tissue microenvironment, which includes fibroblasts, immune cells, stromal proteins, and secreted proteins, can promote the neoplastic behavior of colon cells. Based on our preliminary data, we will study the effects of senescent fibroblasts that accumulate in elderly people and their secreted proteins to promote the tumorigenesis of colon epithelial cells that have acquired age-related oncogenic mutations.

PI_NAMEs: GRADY, WILLIAM MALLORY (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: 3-Dimensional;Ablation;adenoma;age related;aged;Aging;aging related;Automobile Driving;Behavior;Biological Models;Biology of Aging;cancer initiation;cancer risk;carcinogenesis;Cell Aging;Cells;Clonal Expansion;Colon;Colon Carcinoma;colon tumorigenesis;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Dasatinib;Data;Development;DNA Sequence Alteration;Elderly;Engineering;Epigenetic Process;Epithelial Cells;epithelial stem cell;Excision;experimental study;Fibroblasts;genetic approach;high risk;Histologic;Human;Immune;In Vitro;in vivo;Intervention;KRAS oncogenesis;KRAS2 gene;Malignant - descriptor;Malignant Neoplasms;Mediating;Modeling;Molecular;mouse model;Mucous Membrane;Mus;mutant;Mutation;neoplastic;old mice;Older Population;Oncogenes;Oncogenic;Organoids;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Process;Protein Secretion;Proteins;Quercetin;Risk Factors;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;senomorphic;Signal Pathway;Sirolimus;Testing;Tissues;TP53 gene;Transgenic Model;tumor;Tumor Suppressor Genes;tumorigenesis;villin

PROJECT_TITLE: The role of the senescent microenvironment on cancer initiating cells in the colon.


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE/LAY SUMMARY We have discovered that a protein called PD-L1, best known for regulating the immune system through interactions outside of cells, also acts inside immune suppressing T regulatory cells to promote their activity. We have found that intracellular PD-L1 suppresses anti-tumor immunity and promotes the progression of triple negative breast cancer, an aggressive subtype which stage for stage has worse prognosis than other subtypes of breast cancer. Our goal in this proposal is two-fold: 1) investigate how intracellular PD-L1 and the PD-L1 cytoplasmic domain influences T regulatory cell development and function and 2) test whether targeting PD-L1 inside of cells (as opposed to outside of cells where clinically available PD-L1 inhibitors act) can promote anti- tumor immunity to improve triple negative breast cancer therapy.

PI_NAMEs: MUTTER, ROBERT W (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Adoptive Transfer;anti-tumor immune response;Antibodies;Binding;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;Breast Cancer therapy;cancer clinical trial;cancer therapy;CD4 Positive T Lymphocytes;Cell Maturation;Cell Physiology;Cells;Clinical;Cytoplasm;Cytoplasmic Tail;Data;design;Development;disorder subtype;Effector Cell;Equilibrium;experimental study;extracellular;Extracellular Domain;Family member;Foundations;FOXP1 gene;FOXP3 gene;FRAP1 gene;Genes;Genetic Engineering;Genetic Transcription;Genome;Goals;Half-Life;Human;Immune;Immune system;Immunosuppression;Immunosuppressive Agents;Immunotherapy;improved;in vivo;inhibitor;insight;Knock-out;Lysosomes;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Messenger RNA;Metabolic;Metabolism;Molecular;mouse model;mRNA Stability;Mus;next generation;novel;novel therapeutics;Outcome;overexpression;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;programs;promoter;Proteins;Publishing;receptor;Regulatory T-Lymphocyte;Resistance;RNA;RNA Binding;RNA-Binding Proteins;Role;Series;Signal Pathway;Suppressor-Effector T-Lymphocytes;T cell differentiation;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;therapeutic target;therapy resistant;transcription factor;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;Tumor Promotion;tumor-immune system interactions;Variant

PROJECT_TITLE: PD-L1 Intracellular RNA binding function regulates immune suppression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Drug Abuse (NIDA only);Emergency Care;HIV/AIDS;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Prevention;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project narrative  A major impediment to emergency department (ED)-based HIV/HCV screening success is that often ED patients at risk for, or later diagnosed with, HIV and HCV decline testing. In this R01 project, we will assess how well a promising, easy-to-use, one-time, minimal-training-needed, very brief persuasive health communication intervention (PHCI) increases acceptance of testing among adult ED patients who either currently, formerly or never injected drugs and initially declined HIV/HCV screening.

PI_NAMEs: MERCHANT, ROLAND C (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Accident and Emergency department;Adult;Agreement;Area;arm;Behavior Therapy;Belief;Caring;Centers for Disease Control and Prevention (U.S.);co-infection;cohort;comparative efficacy;Cost Effectiveness Analysis;design;Diagnosis;discount;economic evaluation;economic value;Education;efficacy evaluation;Emergency Department patient;Emergency research;Evaluation;Evidence based intervention;Feedback;HCV screening;Health behavior change;health communication;health economics;Health system;Healthcare;Hepatitis C;high risk;HIV/HCV;Hospitals;Human immunodeficiency virus test;Incidence;Injecting drug user;injection drug use;Intervention;intervention delivery;Intervention Studies;Investigation;Israel;Link;Location;Medical;Medical Staff;Modification;New York City;Pamphlets;Participant;Patients;Persons;Persuasive Communication;Pharmaceutical Preparations;Physicians;Pilot Projects;Population;Prevalence;Professional counselor;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;Research;response;Risk;Risk Assessment;screening;screening program;success;Testing;theories;therapy design;Training;Treatment Efficacy;video delivery

PROJECT_TITLE: Evaluation of a persuasive health communication intervention designed to increase HIV/HCV screening among emergency departments patients who currently, formerly or never injected drugs

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: LAWRENCE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE The Haskell-KU Bridge project will diversify the scientific workforce by increasing the likelihood of American Indian / Alaskan Native students attaining baccalaureate degrees and future careers in biomedical, bioengineering, behavioral and health sciences. Our vision is for American Indian and Alaska Native students to see a place for themselves in bioscience careers, to build the skills and resources they need to succeed, and to create a compassionate community of mentors invested in the success of students. The program fosters interactions between Haskell Indian Nations University students and faculty and University of Kansas research mentors to prepare American Indian / Alaska Native students for a broad range of bioscience careers of particular relevance to the needs of Native communities, while increasing the degree attainment of one of the most under-represented groups in STEM fields.

PI_NAMEs: ALLISON-BREWER, NANA ;CHANDLER, JOSEPHINE R (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: 20 year old;Alaska Native;American Indians;Bachelor's Degree;behavioral health;Biological Sciences;Biomedical Engineering;bridge to the baccalaureate;career;cohort;Collaborations;Communities;community building;Community of Practice;design;Development;Ecosystem;Educational Curriculum;Ensure;Environmental Health;Event;evidence base;Funding;Goals;improved;Institution;interest;Investments;K-Series Research Career Programs;Kansas;learning community;meetings;mentoring community;Mentors;Nature;Phase;Program Development;programs;public-private partnership;Recording of previous events;Research;Research Training;Resources;Science;Scientist;Self Efficacy;skill acquisition;skills;skills training;STEM field;student participation;Students;success;tool development;Training;Training Programs;United States National Institutes of Health;Universities;Vision;Work;Workforce Development

PROJECT_TITLE: Bridges to the Baccalaureate Research Training Program at the University of Kansas/Haskell Indian Nations University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_DEPT: GENETICS

PHR: Narrative  This proposal is focused on a major lung disease of older Americans, idopathic pulmonary fibrosis. In IPF, the lungs become stiff and patients experience increasing shortness of breath, often leading to lung failure and death within two to three years. We will explore whether simple drugs related to oils and fats that might be provided as part of the diet can maintain normal function in the lung and slow the progression of pulmonary fibrosis.

PI_NAMEs: KRON, STEPHEN J. (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: 4 hydroxynonenal;Ablation;Acceleration;Acute;Age;aged;Aging;Aldehydes;Alveolus;American;Attention;Automobile Driving;Bleomycin;Blood Vessels;Cancer cell line;candidate identification;Cell Aging;Cell Cycle Arrest;cell injury;Cell Proliferation;Cell Respiration;Cells;Ceramides;Cessation of life;Clinical Trials;Cytoprotection;Defect;Diagnosis;Diet;Disease;Disease Progression;DNA Damage;effective therapy;experience;Exposure to;Fatty acid glycerol esters;feeding;Fibroblasts;Fibrosis;fibrotic lung;Gases;Genetic;Genotoxic Stress;Health;Hydralazine;idiopathic pulmonary fibrosis;improved;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Informatics;interest;interstitial;Interstitial Lung Diseases;Libraries;Link;lipid metabolism;Lipid Peroxidation;lipidomics;Lipids;Literature;Lung;Lung Diseases;lung failure;Mediator;Metabolic Pathway;Metabolism;Methods;Mus;Oils;old mice;Oral;oxidative damage;Oxidative Stress;Pathology;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Physiology;Population;prevent;Process;Prognosis;Proteomics;Pulmonary Fibrosis;Recording of previous events;Research Personnel;Role;Route;senescence;senescent cell;senolytics;Shortness of Breath;Signal Transduction;Smoking History;Sphingolipids;Stress;success;Systems Analysis;therapeutic candidate;Tissues;transcriptomics;uptake;Work

PROJECT_TITLE: Lipid signaling in cellular senescence and tissue aging


NIH_SPENDING_CATS: Neurosciences;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE The Notch signaling pathway has been implicated in a wide range of biological and pathological processes. Using the Drosophila ovarian model, the proposed studies will lead to improved understanding of the diverse effects and regulatory mechanisms of Notch signaling during development and tissue homeostasis. The findings from the proposed studies will help designing new therapeutic strategies for diseases related to aberrant Notch signaling.

PI_NAMEs: DENG, WU-MIN  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Back;Biological;Biological Models;Biological Process;Cell Communication;Cell Cycle;Cell Death;Cell Differentiation Induction;cell growth;Cell Physiology;Cell Polarity;Cell Proliferation;Cell Survival;Cells;Cessation of life;design;Development;Disease;Drosophila genus;egg;Ensure;Environmental Risk Factor;environmental stressor;Epithelial Cells;Event;Feedback;Feeds;Genes;Genetic;Germ Cells;Germ Lines;Growth;Homeostasis;Homologous Gene;human disease;improved;MAPK8 gene;Mitotic;Mitotic Cell Cycle;Modeling;Molecular;neuronal cell body;notch protein;Notch Signaling Pathway;novel;novel therapeutic intervention;Nuclear;Oocytes;Oogenesis;Output;Ovarian;Pathogenesis;Pathologic;Pathologic Processes;Pathway interactions;Phagocytes;Phagocytosis;Physiological;Play;programs;Regimen;Regulation;Role;Series;Signal Induction;Signal Transduction;Somatic Cell;System;Temperature;Testing;Tissues;Tumor Suppressor Proteins;Up-Regulation

PROJECT_TITLE: Notch signaling and germline-soma interactions in the Drosophila ovarian model

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Muscular Dystrophy;Myotonic Dystrophy;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Regulation of the cellular signaling pathways that control the actin cytoskeleton is essential in development and homeostasis. This application focuses on the LIM domain kinases, enzymes which are key regulators of the actin cytoskeleton, and their upstream kinases, the MRCKs. We aim to delineate the atomic-level mechanism of LIMK and MRCK control, to understand how the dual specificity kinases can phosphorylate a range of substrates, and how the LIMKs are recruited to the MRCKs.

PI_NAMEs: BOGGON, TITUS JONATHON (contact);TURK, BENJAMIN E

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: actin depolymerizing factor;Actins;Active Sites;Adaptor Signaling Protein;Address;Architecture;Area;Binding;Binding Proteins;Biochemical;Biological Models;biophysical techniques;Biophysics;Catalytic Domain;CDC42 gene;cell growth regulation;Cells;Cellular Morphology;cofilin;Complex;Consensus Sequence;Coupled;Coupling;Cryoelectron Microscopy;Cues;Cytoplasmic Tail;Cytoskeleton;Data;Development;Distal;Enzymes;Eukaryotic Cell;Event;extracellular;Family;Fibroblasts;Guanosine Triphosphate Phosphohydrolases;Homeostasis;improved;insight;Kinetics;Laboratories;Libraries;LIM Domain;LIM Domain Kinase 1;LIMK1 gene;Mediating;member;Microfilaments;MMP14 gene;Modeling;Molecular;Molecular Conformation;molecular dynamics;Monomeric GTP-Binding Proteins;Movement;Mutagenesis;Mutate;Myotonic Dystrophy;novel;p21 activated kinase;Pathway interactions;Peptides;Phosphorylation;Phosphorylation Site;Phosphotransferases;preference;Process;Protein Kinase;Proteins;recruit;Regulation;rho GTP-Binding Proteins;Roentgen Rays;Role;Scanning;Signal Pathway;Signal Transduction;Specificity;Structure;Substrate Interaction;Surface;transmission process;upstream kinase;Variant;Work;X-Ray Crystallography

PROJECT_TITLE: LIM domain kinases: regulation and substrate recognition

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Congenital malformations, or structural birth defects, are now the leading cause of infant mortality in the US. Of the congenital malformations, congenital heart disease (CHD) is the most common. We have recently developed genetic and biochemical platforms that will enable a systems based approach to uncover the essential protein and protein complexes that in mammalian heart development and in parallel, a patient driven approach to understanding the function of these proteins in human homeostasis and disease.

PI_NAMEs: CONLON, FRANK LEO (contact);SHPARGEL, KARL BRYAN

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Address;Adult;Antibodies;Biochemical;Cardiac;Cardiac Myocytes;cardiogenesis;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Complex;Congenital Abnormality;congenital heart abnormality;Core Protein;Data Set;Development;Disease;Embryo;Embryonic Heart;Enhancers;Epigenetic Process;Gene Activation;Gene Expression;Gene Expression Regulation;Genetic;Genetic study;Genetic Transcription;Goals;Health;Heart;Heart Diseases;heart function;Histone H3;histone methylation;histone methyltransferase;histone modification;Histones;Homeostasis;Human;improved outcome;in vivo;Infant Mortality;insight;Malignant Neoplasms;member;MLL gene;mutant;Mutation;Nucleosomes;Patients;Pharmaceutical Preparations;Post-Translational Protein Processing;programs;promoter;protein complex;protein function;Protein Inhibition;protein protein interaction;Proteins;Proteomics;Regulation;Role;Skeletal Muscle;Structural Congenital Anomalies;structural heart disease;success;System;Testing;Time;Tissues;Transposase

PROJECT_TITLE: Function and regulation of chromatin remodeling complexes in cardiac development and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-R(02)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE The last step in cell division, abscission, relies on a transient structure called the midbody, which resides inside the intercellular bridge between newly forming daughter cells. It consists of overlapping spindle midzone microtubules which are coated with electron dense material called the midbody matrix. Long conceptualized as a structural remnant subject to degradation following cytokinesis, emerging data suggest that midbody remnants (MBsomes) play instructive post-mitotic roles in establishing cell fate, proliferation state, tissue polarity, cilia formation, neuron function, and oncogenesis. However, very little is known about the functional significance of the electron dense material. My lab has uncovered a surprising novel function for this electron dense material in that it is a site of RNA storage and is a novel actively translating RNP granule with a uniquely complex life cycle comprised of both membrane-less and membrane-bound phases, that we are calling the MB-granule (for Midbody-granule). Our current research goals are to understand how the midbody behaves as a novel form of intercellular communication, to define distinct therapeutic targets for midbody-mediated human diseases that range from cancer to neurodegeneration.

PI_NAMEs: SKOP, AHNA RENEE (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Active Sites;Address;Affect;Anaphase;Aneuploidy;Architecture;Binding;Biogenesis;Biological Assay;Biological Response Modifier Therapy;biophysical properties;Cell division;cell fixing;cell type;Cells;Characteristics;Chemistry;Cilia;Clustered Regularly Interspaced Short Palindromic Repeats;Color;common treatment;Complex;Coupled;Cytokinesis;Cytoplasm;Cytoplasmic Granules;Data;daughter cell;delivery vehicle;Disease;Double-Stranded RNA;Electrons;Embryo;Excision;Exhibits;extracellular;extracellular vesicles;genetic manipulation;Genomics;Goals;Hela Cells;Human;human disease;innovation;insight;intercellular communication;Kinesin;Knock-out;Life Cycle Stages;LOX gene;Malignant Neoplasms;Mediating;Membrane;Messenger RNA;Microcephaly;Microtubules;Mitosis;Mitotic;Modeling;Molecular;Motor;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;Nuclear Envelope;Oncogenic;Organelles;Phase;Physical condensation;Play;pluripotency;postmitotic;Proliferating;Proteins;Publishing;Regulation;Reporting;Research;Reverse Transcriptase Polymerase Chain Reaction;Ribonucleoproteins;RNA;RNA Transport;Role;scaffold;Signal Transduction;Site;spatiotemporal;stem cells;Structure;Syndrome;System;therapeutic target;Tissues;Transcript;transcription factor;transcriptome sequencing;transcriptomic profiling;Translating;Translation Initiation;Translations;tumorigenesis;ultra high resolution;Work

PROJECT_TITLE: Functional analysis of mammalian midbody RNA in post-mitotic signaling functions

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Clinical Research;Genetics;Infectious Diseases;Neurosciences;Sarcoidosis

ORG_DEPT: NEUROLOGY

PHR: Neurosarcoidosis is the neurological complication of sarcoidosis, a systemic inflammatory disorder of unknown cause. This proposal will refine clinical phenotypes in neurosarcoidosis and will use state of the art molecular, immunology and RNA sequencing methods to elucidate pathogenic mechanisms and to uncover potential antigens or pathogens associated with neurosarcoidosis.

PI_NAMEs: PARDO-VILLAMIZAR, CARLOS A (contact)

PROGRAM_OFFICER_NAME: SRINIVASAN, SUDHA

PROJECT_TERMS: Acute-Phase Proteins;African American population;Antibodies;Antibody Response;Antigen Targeting;Antigens;Autoantigens;Autoimmune Responses;Automobile Driving;Bacteriophages;Biological;Biological Markers;Biological Response Modifiers;biomarker discovery;Blood;Cerebrospinal Fluid;Chronic;Clinical;clinical center;Clinical Data;clinical phenotype;cohort;Collaborations;Collection;Complication;Comprehensive Health Care;Critical Pathways;cytokine;Data;design;Development;Diagnosis;Disease;Disease Outcome;Disease Pathway;Disease Progression;disorder control;Encephalitis;Etiology;European;Exposure to;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genomics;Genus Mycobacterium;Goals;Granuloma;Granulomatous;Immune;Immune response;Immunologic Markers;Immunologics;Immunology;Immunoprecipitation;Individual;Infection;Inflammation;Inflammatory;insight;Interferon Type II;Interleukin-6;Libraries;Link;Meningitis;Methods;microbial;Molecular;Molecular Profiling;mycobacterial;Myelitis;neuroimaging;Neuroimmune;neuroinflammation;Neurologic;Neurologic Symptoms;neurosarcoidosis;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;pathogen;Pathogenesis;pathogenic microbe;Pathogenicity;Pathology;Pathway interactions;Patient Care;Patient Recruitments;Patients;Phage Display;Phase;Phenotype;Play;Precipitation;Predisposition;Process;Prognosis;prospective;Readiness;Relapse;repository;response;Role;Sampling;Sarcoidosis;System;Techniques;therapeutic target;TNF gene;transcriptome;transcriptome sequencing;transcriptomics;treatment response

PROJECT_TITLE: Neurosarcoidosis: Clinical Phenotype, Biomarkers and Immunopathogensis

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of new metabolic connections between proteins and metabolites is ultimately expected to increase our range of treatable disease, which will lead to new therapeutics and increase healthy lifespan. The democratization of methods enabled by the proposed research will greatly increase the pace of metabolic pathway discovery. Thus, the proposed research is relevant to the NIH’s mission to develop fundamental methods and new technologies, and understand the principles that underlie living organisms.

PI_NAMEs: MEYER, JESSE  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Area;artificial intelligence algorithm;artificial intelligence model;Biochemical;Data;Data Analyses;Data Collection;data integration;data resource;Data Set;deep neural network;Democracy;Diabetes Mellitus;Disease;drug development;experimental study;Genetic;Goals;healthspan;Hour;Human;innovation;Knowledge;Learning;Literature;Malignant Neoplasms;medical schools;Metabolic;Metabolic Pathway;Metabolism;metabolome;Methods;Mission;Modeling;Multiomic Data;multiple omics;Nature;new technology;novel;novel therapeutics;Organism;Pathway interactions;prevent;protein metabolite;Proteins;Proteome;Public Health;Publishing;Research;Sampling;System;Techniques;Testing;therapeutic target;therapy development;United States National Institutes of Health;Vision;Wisconsin;Yeasts

PROJECT_TITLE: Democratizing Multi-Omics to Expedite Discovery of Hidden Metabolic Pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Liver Disease

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Metastasis is the overwhelming cause of death in solid organ tumors like colorectal cancer but remains poorly understood at the molecular level. We have discovered a critical role for the type 3 inositol 1,4,5-triphosphate receptor (ITPR3), a protein involved in controlling intracellular calcium signaling, in facilitating colorectal cancer metastasis to the liver. The proposed research will define the mechanisms by which ITPR3 allows colorectal cancer cells to overcome physiological barriers like extracellular matrix detachment to colonize distant tissues and test its potential as a therapeutic target, leading to innovative strategies to block cancer recurrence or progression.

PI_NAMEs: MOY, RYAN  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: adenovirus mediated delivery;Bioenergetics;Bioinformatics;Biology;Calcium;Calcium Signaling;cancer cell;Cancer Etiology;Cancer Model;Cancer Patient;cancer recurrence;career development;Cause of Death;Cell Death;Cell Proliferation;Cell Survival;Cells;Cellular Stress;Cessation of life;Circulation;Clinical;clinical training;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Colorectal Cancer;colorectal cancer metastasis;Cues;Data;DCC gene;design;Development Plans;Distant;Endoplasmic Reticulum;Environment;Epithelium;experience;experimental study;extracellular;Extracellular Matrix;FRAP1 gene;Funding;gastrointestinal;Generations;Genes;genome-wide;Glucose;Impairment;improved;improved outcome;In Vitro;in vivo;Injections;innovation;Inositol;insight;Institution;Laboratories;Link;Liver;Liver parenchyma;Malignant Neoplasms;Mediating;Medical Oncology;member;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Metabolic;Metabolism;metabolomics;metastatic colorectal;Metastatic Neoplasm to the Liver;Modernization;Molecular;Molecular Biology;mortality;mouse model;Neoplasm Metastasis;NF-kappa B;novel;Nuclear;Oncology;oncology service;Organ;Organoids;Outcome;Oxidation-Reduction;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phase;Physicians;Physiological;Polyribosomes;Positioning Attribute;Pre-Clinical Model;prevent;Primary Neoplasm;Process;promoter;Proteins;Proteomics;receptor;relB protein;Research;response;ribosome profiling;Role;Sampling;Scientist;Second Messenger Systems;short hairpin RNA delivery;Signal Transduction;Site;skills;small hairpin RNA;Solid;Stress;Systemic Therapy;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissues;Training;transcriptome sequencing;Translations;tripolyphosphate;tumor;tumor progression;United States;Universities;Work;Xenograft procedure

PROJECT_TITLE: Defining the mechanism of inositol 1,4,5-triphosphate receptor-mediated metastatic liver colonization in colorectal cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Retinopathy of prematurity is a leading cause of childhood blindness worldwide. The fovea, a critical location in the retina determining visual acuity and visual function, and the blood vessels around it, are maldeveloped in infants with retinopathy of prematurity. However, how these blood vessels form during development of the human fovea remains unclear. This research will advance our understanding of the fundamental knowledge of how the blood vessels around the fovea form in infants, and how they change in diseased states such as preterm birth or retinopathy of prematurity.

PI_NAMEs: CHEN, XI  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: 3-Dimensional;Adult;Age;Anastomosis - action;Angiography;Animal Model;Biomedical Engineering;Blindness;Blood capillaries;Blood Vessels;Child;Childhood;Complex;Cone;Data;density;Development;Devices;Disease;disorder of macula of retina;Early Diagnosis;Etiology;Exhibits;fovea centralis;Functional disorder;Fundus;Gestational Age;Goals;Human;Image;imaging system;Imaging Techniques;Impairment;improved;in vivo;Individual;Infant;Infant Development;insight;Knowledge;late life;Location;longitudinal analysis;macular edema;Methods;multidisciplinary;Neurological disability;Ophthalmologist;Optical Coherence Tomography;Pathology;Pattern;Photoreceptors;Pigmentation physiologic function;Pregnancy;premature;Premature Birth;Premature Infant;Prevalence;Process;Recording of previous events;Research;Retina;Retinopathy of Prematurity;Sampling;Source;Speed;System;Three-dimensional analysis;Translations;Vascular Diseases;Vascularization;Vision;Visual Acuity;Visual disability;Visual impairment;Visualization;Work

PROJECT_TITLE: Elucidating perifoveal vascular development in infants

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

PHR: NARRATIVE Intellectual disability (ID) affects 1-3% of the world population. Identification of genes and variants that cause ID in a variety of populations. i.e., African, Asian, and European is highly beneficial for understanding brain development and mechanism and for diagnosis of ID through genetic screening.

PI_NAMEs: LEAL, SUZANNE M (contact);SCHRAUWEN, ISABELLE VEERLE SUZANNE

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Africa;African;African American population;African ancestry;American;Americas;Animal Model;Asia;Asian;Asian population;Brain;Candidate Disease Gene;causal variant;cell type;Cells;Clinical;Collection;Color;Coniferophyta;Consanguinity;Copy Number Polymorphism;Data;Data Analyses;Data Set;Databases;Developed Countries;Developing Countries;Development;Diagnosis;Diagnostic;Dideoxy Chain Termination DNA Sequencing;digital;Dimensions;Disease;DNA;early screening;Environmental Exposure;Etiology;Europe;European;Evaluation;Exclusion;exome;exome sequencing;Expression Profiling;Extended Family;Family;Family member;Family Study;Female;Finland;FMR1 repeat expansion;Founder Generation;Fragile X Syndrome;Frequencies;Future;Gene Expression;Gene Frequency;gene function;Genes;Genetic;genetic pedigree;Genetic Predisposition to Disease;Genetic Screening;genome sequencing;Genomics;Human;Hungary;Impaired cognition;improved;Infection;insertion/deletion mutation;insight;Intellectual functioning disability;Knowledge;Mali;member;Minority Groups;minority health;Modality;Modeling;Molecular;Mus;Nervous System;Neurodevelopmental Disorder;next generation sequencing;novel;Nuclear;Nuclear Family;Pakistan;Parents;Pathogenicity;Phenotype;Play;Population;proband;protein function;Proteins;Public Health;Resources;Role;Sampling;segregation;Sequence Analysis;sequencing platform;Severities;Single Nucleotide Polymorphism;single-cell RNA sequencing;Slave;spatiotemporal;Structure;Techniques;Testing;therapeutic development;Therapeutic Intervention;therapy development;Time;tool;trait;Trauma;Untranslated RNA;Validation;Variant;Visualization;whole genome;X Inactivation;X-linked intellectual disability

PROJECT_TITLE: Elucidating the Genetic Etiology of Intellectual Disability in African, Asian, and European Families

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative: Immunotherapy drugs are most effective when used in combination but can be very toxic. Here we propose a new approach to confine immunotherapy drugs to tumors, by binding the drugs to the most common vaccine adjuvant, alum. Alum-bound therapeutics can be injected intratumorally and stimulate an immune response that attacks cancer throughout the body, providing a promising strategy to create safer and more effective immunotherapies.

PI_NAMEs: IRVINE, DARRELL J (contact);WITTRUP, KARL DANE

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: Abscopal effect;Address;Adjuvant;Adsorption;Affinity;Agonist;Aluminum Hydroxide;aluminum sulfate;anti-tumor immune response;Antibodies;Antigens;Antitumor Response;Bilateral;Binding;Bypass;cancer immunotherapy;Cells;Circulation;Combination immunotherapy;Combined Modality Therapy;cytokine;design;Diffusion;Disease;Distal;Dose;efficacy evaluation;Engineering;Extravasation;Genetically Engineered Mouse;Human;hydroxyl group;Immune;Immune response;Immunity;Immunologic Stimulation;Immunophenotyping;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Injections;Interleukin-12;Interleukin-2;Lesion;Licensing;Ligands;Lymphocyte;lymphocyte trafficking;Malignant Neoplasms;Mediating;Melanoma;Metabolic Clearance Rate;Modeling;Modification;Motility;novel strategies;optimal treatments;particle;Pathway interactions;Penetrance;Peptides;Pharmaceutical Preparations;Phosphorylation;Phosphoserine;Population;Positioning Attribute;Pre-Clinical Model;Production;Proteins;Reaction;Recombinant Proteins;Research Personnel;response;Role;Route;Signal Transduction;Site;Stretching;Surface;System;T-Lymphocyte;technology platform;Testing;Therapeutic;Therapeutic Agents;Therapeutic Index;Toxic effect;translational approach;Treatment Efficacy;Treatment Protocols;tumor;Tumor Immunity;tumor microenvironment;uptake;Vaccine Adjuvant;Vaccine Antigen;vaccine efficacy;vaccine immunogenicity;Vaccines

PROJECT_TITLE: Localized immunotherapy using alum-binding therapeutics

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative  In this proposal, we develop a suite of improved methodological and computational tools for Mendelian ran-domization, an approach for measuring causal effects using genetic associations. We focus on developing tech-niques that integrate multiple data sources into an analysis to improve accuracy. Our goal is to create innovative tools that allow clinical and biological investigators to make full use of rich data resources to obtain accurate causal estimates.

PI_NAMEs: MORRISON, JEAN V. (contact)

PROGRAM_OFFICER_NAME: ZHANG, LI

PROJECT_TERMS: Accounting;Address;Affect;Alzheimer's disease risk;Awareness;biobank;Biological;C-reactive protein;Cardiometabolic Disease;cardiometabolic risk;Catalogs;Clinical;Computer software;computerized tools;Confounding Factors (Epidemiology);Coupled;Data;data integration;data resource;Data Set;Data Sources;Databases;Deposition;Elements;Ensure;genetic association;genome wide association study;Genotype;Goals;heart disease risk;Heritability;human disease;improved;Individual;innovation;Knowledge;LDL Cholesterol Lipoproteins;Linkage Disequilibrium;Measurable;Measures;Mediating;Mendelian randomization;Methodology;Methods;model building;Modeling;Modernization;multiple data sources;National Human Genome Research Institute;novel;open source;Outcome;Pattern;Performance;phenome;Plasma;pleiotropism;public database;Quality Control;randomized trial;Research Methodology;Research Personnel;Risk Factors;Role;Sampling Studies;Screening procedure;Selection Bias;simulation;software development;Source;Statistical Methods;statistics;study population;symposium;Techniques;Testing;tool;trait;user friendly software;user-friendly;Variant;Work

PROJECT_TITLE: Mendelian randomization for modern data: Integrating data resources to improve accuracy of causal estimates.

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Vaccine Related

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: A surprising aspect of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is the minimal acute disease in children. This work will characterize SARS-CoV-2-specific B cell responses across the age spectrum and define if the early life immune landscape provides benefits in preventing severe acute disease and/or immune advantages that could be leveraged for prevention.

PI_NAMEs: FOUDA AMOU OU, GENEVIEVE GINY  (contact);KELLY, MATTHEW SCOTT;PERMAR, SALLIE R.

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 18 year old;2019-nCoV;Activities of Daily Living;acute COVID-19;Acute Disease;Adult;Age;age difference;age related;Antibodies;Antibody Response;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Antigens;Avidity;B cell repertoire;B-Lymphocytes;Binding;biophysical properties;Cessation of life;Characteristics;Child;Child Care;Childhood;Communities;Data Set;design;Development;Disease;Disease Outcome;Enrollment;Epitopes;Evaluation;Fc Receptor;Frequencies;Genes;Genomics;glycosylation;Goals;Herd Immunity;HIV;HIV Infections;Hospitalization;Hospitalized Child;Immune;Immune response;Immunity;Immunogenetics;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Individual;Infection;Inflammation;Inflammatory;insight;Kinetics;Knowledge;Life;Longitudinal Studies;Measures;Memory B-Lymphocyte;Messenger RNA;Modernization;Monoclonal Antibodies;Multisystem Inflammatory Syndrome in Children;Natural Immunity;Nature;neutralizing antibody;novel;Outcome;pandemic disease;pathogen;Persons;Phenotype;Population;post SARS-CoV-2 infection;predictive modeling;Predisposition;prevent;Prevention;protective effect;Proteins;Resistance;respiratory virus;response;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 variant;school reopening;Schools;Serology;severe COVID-19;Sorting;Specificity;Syndrome;System;Testing;Time;Vaccinated;Vaccination;vaccination strategy;vaccine distribution;Vaccines;Variant;Viral;Virus;Work

PROJECT_TITLE: Early life B cell responses and inflammation following SARS-CoV-2 infection

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative While it is clear that the microbiota play a key role in human health, we lack an understanding of the physiological processes that determine microbiota composition across the body. To address this gap, the the goals of this proposal are to i) identify relationships between host genes and mucosal bacteria and archaea, ii) identify non-prokaryotic elements of the human microbiome associated with human gene expression and ii) demonstrate causal relationships between the microbiome and host gene expression. Ultimately, the results of this project will inform our understanding of the relationship between the microbiota and host in health and disease and highlight areas of interest for novel, microbiome-based therapeutics.

PI_NAMEs: DAVENPORT, EMILY  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Address;Archaea;Area;Bacteria;Body System;cell type;Complex;Data;Disease;Ecosystem;Elements;Epidemiologic Methods;Etiology;Eukaryotic Cell;fecal microbiome;functional genomics;fungus;Gene Expression;Genes;Genetic;genetic approach;genetic epidemiology;Genomic approach;Goals;Gut Mucosa;Health;Heritability;host microbiota;Human;Human body;Human Genetics;Human Microbiome;improved;In Vitro;Individual;insight;interest;Lead;Lung;lung microbiota;microbial;microbiome;microbiome composition;microbiome therapeutics;microbiota;microbiota composition;Molecular;Mucous Membrane;novel;Organism;Pathway interactions;Physiological;Physiological Processes;Play;programs;Research;Research Methodology;Sampling;single-cell RNA sequencing;Site;Surface;targeted treatment;Tissues;trait;Virus;Work

PROJECT_TITLE: Characterizing human-microbiome interactions via molecular and functional genomic approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PISCATAWAY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Response inhibition is a key aspect of learned behavior and is impaired in a variety of neurological disorders that involve impulsivity, including Huntington’s disease, Tourette’s syndrome, and obsessive-compulsive disorder. This project uses in vivo and ex vivo approaches in mouse models to investigate cortical and thalamic influences on the neural circuits of the dorsal striatum, an important site of sensory-motor integration and learning. The results of this project will further our understanding of the neural circuit mechanisms underlying learned response inhibition and have implications for understanding and treatment of impulsive behavior.

PI_NAMEs: MARGOLIS, DAVID J (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Anatomy;Area;Behavior;Behavior Control;behavior influence;Behavioral;Behavioral Mechanisms;behavioral response;Brain;Cell Nucleus;cell type;Cells;Chronic;cognitive control;Color;Corpus striatum structure;Discrimination;discrimination task;Dorsal;Electrophysiology (science);experimental study;Fiber;Gilles de la Tourette syndrome;Goals;Huntington Disease;Image;Impairment;Impulsive Behavior;Impulsivity;in vivo;in vivo imaging;Interneurons;Knowledge;learned behavior;Learning;Measurement;Measures;Medial;Medial Dorsal Nucleus;Mediating;Modeling;Motor;mouse model;Mus;neocortical;nerve supply;Nervous System Disorder;neural;neural circuit;Neural Pathways;Neurons;Obsessive-Compulsive Disorder;optogenetics;Parvalbumins;patch clamp;Pathway interactions;Pattern;Performance;Photometry;Play;Population;Population Dynamics;response;Role;Sensory;Shapes;Signal Transduction;Site;Slice;Somatosensory Cortex;Synapses;Synaptic plasticity;System;Tactile;Task Performances;Testing;Texture;Thalamic Nuclei;Thalamic structure;Touch sensation;two-photon;Vibrissae;Work

PROJECT_TITLE: Neural circuit mechanisms underlying cognitive control of sensory-guided behavior

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Title: Coordination of molecular motor activity in intracellular transport and assembly of cytoskeletal architecture. P.I. – Richard J. McKenney Project Narrative: The cytoskeleton of cells is a system of molecular filaments used as highways for the transport of cargo within living cells, a process critical for human health and disease. Molecular motor molecules actively move along these filaments carrying cargo to specific destinations within cells, but how this process is regulated for correct cargo transport is not understood. This proposal seeks to answer basic questions about how cells control this process, with a long-term goal to provide new avenues of inquiry into the mechanisms of the many diseases related to impaired cytoskeletal function, such as ALS, Huntington’s disease, and Alzheimer’s disease.

PI_NAMEs: MCKENNEY, RICHARD JAMES (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Alzheimer's Disease;Architecture;ATP Hydrolysis;Behavior;Binding;Biochemistry;Biological;Biological Assay;Cells;Chemicals;Complex;Cytoplasm;Cytoskeleton;Defect;Destinations;Disease;Dynein ATPase;Environment;Eukaryota;Family;Filament;Goals;Health;Homeostasis;Human;human disease;Huntington Disease;Impairment;In Vitro;in vivo;Individual;insight;Intracellular Transport;Kinesin;Lead;Link;Microtubule-Associated Proteins;Microtubules;Molecular;Molecular Motors;Motility;Motion;Motor;Motor Activity;Motor output;Neurodegenerative Disorders;novel;Pathologic;Pick Disease of the Brain;Process;Property;Protein Dynamics;reconstitution;recruit;Regulation;Research;scaffold;single molecule;spatiotemporal;System;tau Proteins;Testing;tool;Translating;Work

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Dopamine signaling is crucial for proper development and function of the retina and reduced signaling is associated with many visual disorders. The dopaminergic amacrine cells are the primary source of dopamine. Understanding molecular mechanisms that specify the formation of these cells is critical to develop therapeutics that can restore dopamine levels in diseased states.

PI_NAMEs: MACKIN, ROBERT  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adult;Alleles;Amacrine Cells;analog;Attenuated;Basic Science;Cell Physiology;Cells;Circadian Rhythms;Cues;Data;Defect;Development;Diabetic Retinopathy;Disease;Dopamine;dopaminergic neuron;Embryo;Enzymes;experimental study;Eye;gain of function;Generations;Genetic Transcription;Goals;High Pressure Liquid Chromatography;Individual;inducible Cre;Interneurons;Knowledge;Lead;loss of function;Measures;Microscopy;Molecular;Molecular Target;Mus;mutant;Myopia;nanoscale;Neuromodulator;neuron loss;Neurons;normal aging;novel;novel therapeutics;Parkinson Disease;Pathogenesis;Pathway interactions;pharmacologic;Phosphotransferases;Population;prevent;Production;progenitor;programs;Protein-Serine-Threonine Kinases;Regenerative Medicine;repaired;Retina;Retinal Diseases;retinal neuron;Retinitis Pigmentosa;Signal Pathway;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Source;Specific qualifier value;stem cell population;STK11 gene;Tamoxifen;Testing;Therapeutic;Time;Tyrosine 3-Monooxygenase;ultra high resolution;Vision;Vision Disorders;Visual;Visualization

PROJECT_TITLE: Mechanisms that govern dopaminergic amacrine cell diversity


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Genetics;Mental Health;Mental Illness;Neurosciences;Pediatric;Precision Medicine

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Treated categorically, anxiety and depression demonstrate high co-morbidity and poor discriminability and inter-rater reliability, likely stemming from their high genetic correlation and shared symptomatology along a distress subfactor of internalizing symptoms. The proposed research would provide a critical step in advancing our understanding of the neurodevelopmental signatures related to symptom dimensions of anxiety and depression. The innovative analytic and data acquisition approaches proposed stand to provide information to clinicians regarding neurodevelopmental biomarkers for individualized therapeutic intervention.

PI_NAMEs: MAREK, SCOTT  (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;adverse outcome;Affect;Amygdaloid structure;Anxiety;Anxiety Disorders;anxiety symptoms;anxious;Award;Biological;Biological Markers;biotypes;Brain;career;Child;Clinical;Clinical Data;cognitive development;comorbidity;critical developmental period;Data;data acquisition;Data Collection;Data Set;Depressive disorder;depressive symptoms;design;Development;Diagnosis;Diagnostic;Dimensions;disability;Disease;Disease Progression;Distress;early adolescence;Early treatment;economic cost;endophenotype;Exhibits;Genetic;Genetic Predisposition to Disease;Genetic study;Goals;Heritability;Image;indexing;Individual;individualized medicine;innovation;Intervention;Magnetic Resonance Imaging;Major Depressive Disorder;Maps;Measurable;Measures;Mental Depression;Mental disorders;Mentorship;Methodology;Methods;Monozygotic twins;Motor;National Institute of Mental Health;neural;neuroimaging;neuropsychiatric disorder;Pathway interactions;Patients;Pattern;personalized biomarkers;personalized medicine;Phenotype;polygenic risk score;Prefrontal Cortex;Prevalence;Process;programs;Psychopathology;Qualifying;recruit;Research;Research Domain Criteria;Research Personnel;Resources;Risk;Sampling;Severities;Specificity;stem;symptom cluster;symptomatology;Symptoms;Techniques;Therapeutic Intervention;Training;Twin Multiple Birth;Universities;Washington

PROJECT_TITLE: Neurodevelopmental profiles related to transdiagnostic and disorder-specific symptoms of anxiety and depression


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Prevention;Substance Misuse

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARATIVE 20 million Americans battle with substance use disorder, typically initiated during adolescence. This project will derive risk scores forecasting hazardous substance use in high school students through complex analyses of brain imaging, demographic, health, and cognitive test data. The proposed novel analysis will use two large, longitudinal, publicly-available datasets (National Consortium on Alcohol and Neurodevelopment in Adolescence and Adolescent Brain Cognitive Development) and if our forecasting is accurate, future studies can assess the potential of the risk scores for enhancing preventative care within precision medicine settings.

PI_NAMEs: POHL, KILIAN MARIA (contact);TAPERT, SUSAN F

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: 16 year old;Accounting;Adolescence;Adolescent;Adverse effects;Affect;Age;aged;Alcohols;American;Attenuated;Behavior;Behavior Control;boys;Brain;Brain imaging;brain volume;Cannabis;Cellular Phone;Cognition;Cognitive;cognitive control;cognitive development;cognitive testing;cohort;Complex Analysis;cost;COVID-19 pandemic;Data;Data Set;demographics;Development;Developmental Delay Disorders;Dimensions;Emotions;Enrollment;Environment;Environmental Risk Factor;experience;Family history of;follow-up;frontal lobe;Future;girls;Hazardous Substances;Health;Heterogeneity;high school;High School Student;improved;Impulsivity;Individual;learning strategy;Link;Machine Learning;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mediating;Mental Health;Modeling;modifiable behavior;morphometry;Motor;Negative Reinforcements;neural circuit;neuroadaptation;neurodevelopment;novel;Participant;Patient Self-Report;Pattern;Peer Pressure;personalized approach;poor sleep;Population;Positive Reinforcements;precision medicine;Prevention;Prevention program;Preventive care;Process;Publishing;resilience;Rewards;Risk;Risk Assessment;Risk Factors;risk mitigation;risk prediction;Risk Taking;self supervised learning;sex;Site;Sleep;sleep behavior;Structure;substance use;Substance Use Disorder;substance user;Surveys;Symptoms;Technology;Testing;Thinness;Time;Tobacco;Trauma;Update;Visit;Youth

PROJECT_TITLE: Interpretable Deep Forecasting of Hazardous Substance Use during High School


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE While the spectrum of genetic mutations in myeloid leukemia has been comprehensively studied, the relevance of the diversity of mutations within a single patient remains a significant hurdle in delivering efficacious therapy to patients. The proposed research here will use mouse models to identify contexts in which oncogenic FLT3 mutations are necessary for disease progression. These studies will provide insights into improved therapeutic strategies for patients with FLT3-mutant acute myeloid leukemia.

PI_NAMEs: BOWMAN, ROBERT LYLE (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Ablation;Acute Myelocytic Leukemia;Address;Affect;Alleles;anti-cancer research;Automobile Driving;career;career development;Cells;Chemicals;Clinical;Clinical Trials;clinically relevant;Clonal Evolution;Coculture Techniques;Communication;CRISPR/Cas technology;Dependence;Development;Disease;Disease Progression;DNA Sequence Alteration;DNMT3a;Doctor of Philosophy;efficacious treatment;epigenetic drug;Epigenetic Process;epigenome;Event;FDA approved;fitness;FLP recombinase;FLT3 gene;FLT3 inhibition;FLT3 inhibitor;Foundations;Future;Gene Frequency;Genes;Genetic;genetic epidemiology;Genetic Transcription;genetic variant;Genomics;Goals;Grant;Head;Hematologic Neoplasms;Heterogeneity;Human;improved;In complete remission;in vivo;inhibitor;insight;Intervention;Laboratories;Lead;Lesion;leukemia;leukemia treatment;Leukemic Cell;leukemic transformation;leukemogenesis;Link;Maintenance;Malignant - descriptor;Malignant Neoplasms;member;Membrane;Memorial Sloan-Kettering Cancer Center;Mentors;Methods;Minor;Modeling;Molecular;mouse model;mutant;Mutate;Mutation;Myeloid Leukemia;novel;novel therapeutics;NPM1 gene;Oncogene Activation;Oncogenes;Oncogenic;Oncology;Outcome;Pathogenesis;patient subsets;Patients;Pharmaceutical Preparations;Phase;Postdoctoral Fellow;Predisposition;Process;Prognostic Marker;programs;Protein Tyrosine Kinase;Receptor Protein-Tyrosine Kinases;recombinase;Recurrent disease;Relapse;relapse patients;Reporter;Research;research and development;Research Institute;Resistance;Resources;response;Role;Signal Transduction;Site;skills;small molecule;Somatic Mutation;success;System;Technical Expertise;Testing;Therapeutic;therapeutic target;tool;tool development;Treatment Efficacy;treatment response;tumor microenvironment

PROJECT_TITLE: Interrogating oncogene-dependency and mutation order in FLT3 mutant AML

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project narrative This research is relevant to public health because understanding how the initial wave of the COVID-19 pandemic affected people who inject drugs will inform HIV prevention efforts and other interventions to mitigate ongoing and downstream negative health consequences for people who use drugs. This research is in line with NIDA HIV research priority to increase understanding of etiology, pathogenesis, spread, and persistence of HIV among people who use drugs and is responsive to PAR-20-036 with an explicit focus on understanding HIV disease dynamics with the goal of ending HIV in the context of the COVID-19 pandemic.

PI_NAMEs: GENBERG, BECKY LYNN (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;AIDS prevention;antiretroviral therapy;Anxiety;Baltimore;Behavior;Behavioral;Caring;Characteristics;China;Clinical Data;cohort;Communities;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Collection;Disease;Disease Outbreaks;disorder prevention;Drug usage;Drug user;Economics;Enrollment;Epidemic;Equation;Equipment;Etiology;experience;Exposure to;Failure;follow-up;Frequencies;Future;Geography;Goals;Harm Reduction;Health;Health Services Accessibility;Hepatitis C;Heroin;high risk behavior;HIV;HIV risk;Homelessness;improved;Incidence;Individual;Injecting drug user;injection drug use;Injections;Interruption;Intervention;Interview;Intravenous;Kentucky;Laboratories;Link;Massachusetts;Measures;Mental Depression;Mental Health Associations;Methods;Modeling;mortality;National Institute of Drug Abuse;Needle Sharing;operation;opioid epidemic;opioid use;opioid use disorder;Overdose;pandemic disease;Participant;Pathogenesis;Pennsylvania;Persons;Pharmacotherapy;Play;Population;prevent;Prevention strategy;Prospective cohort;psychosocial;Public Health;public health emergency;Relapse;Research;Research Priority;Resources;response;Risk;Risk Behaviors;Risk Factors;Role;Running;Rural;SARS-CoV-2 transmission;Services;Signal Transduction;social;Social isolation;Social Network;Social support;Sterility;Stress;substance use;suburb;synthetic opioid;Syringes;therapy design;transmission process;treatment strategy;trend;United States;urban area;Viral;Vulnerable Populations;Washington;West Virginia

PROJECT_TITLE: When pandemics collide: The intersection of the opioid crisis, COVID-19 and HIV pandemics among people who inject drugs in the United States

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Public Health Relevance Statement Knowledge of human central nervous system (CNS) development has been significantly limited by the availability of human nervous tissues. This research will apply recent advances in stem cell-based in vitro models of human CNS development to investigate some key molecular and cellular events involved in early human CNS development. In addition to advancing knowledge of human CNS development, our research could assist in the rational design of differentiation protocols of human stem cells for CNS disease modeling and cell therapy, and in high-throughput drug and toxicity screens for prevention and treatment of CNS diseases.

PI_NAMEs: FU, JIANPING  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 3-Dimensional;Address;Anatomy;Animal Model;Architecture;Biological Assay;Biomedical Engineering;Brain;Cell Differentiation process;Cell Therapy;Central Nervous System;Central Nervous System Diseases;Data;Development;Diagnosis;differentiation protocol;Disease;disease model;Dorsal;Ectoderm;Embryo;embryo tissue;Embryology;Event;Exhibits;Foundations;Genetic;Geometry;Goals;high throughput screening;hindbrain;Homeobox Genes;Human;human model;human pluripotent stem cell;human stem cells;in vitro Model;in vivo;innovation;Knowledge;Life;Measurement;Mental disorders;Microfluidics;Midbrain structure;Modeling;Molecular;morphogens;nerve stem cell;Nerve Tissue;nervous system development;Nervous System Disorder;neural;neural patterning;neural plate;Neural tube;Neural Tube Development;neurodevelopment;Neurodevelopmental Disorder;Neuronal Differentiation;Neurons;neuroregulation;notochord;Organoids;Pathology;Pattern;Pharmaceutical Preparations;Play;Prevention;Process;progenitor;Property;Prosencephalon;public health relevance;rational design;Research;Role;self organization;Signal Transduction;spatiotemporal;Specific qualifier value;Spinal Cord;Stem Cell Development;stem cell model;stem cell therapy;stem cells;Structure;success;Techniques;Testing;Time;Tissues;tool;Toxic effect;Tubular formation

PROJECT_TITLE: A Fully Patterned Human Neural Tube Model Using Microfluidics

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Services;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE This project is relevant to public health because it aims to improve the quality and safety care delivered by providers in neonatal intensive care units (NICUs). The research is significant because it will improve neonatal patient safety by changing the way NICU provider workload is measured and used for workload management, organizational learning, and improvement. The project is innovative because it will use data readily accessible in electronic health records to develop a new multi-level model of workload for neonatal nurse practitioners and use this model to guide the design and development a future clinical decision support tool for provider workload management and safety improvement.

PI_NAMEs: FRANCE, DANIEL JOSEPH (contact);GURSES, AYSE PINAR

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Academic Medical Centers;Address;Affect;Caring;clinical decision support;clinical practice;Collaborations;Communication;Complex;COVID-19 pandemic;Critical Illness;Data;Data Element;design;Development;Diagnostic;Dimensions;Dose;Electronic Health Record;Engineering;Environmental Risk Factor;environmental stressor;Evaluation Studies;Event;experience;Focus Groups;Foundations;Funding;Future;Growth;health information technology;Health system;Healthcare;Hospitals;Hour;Human;human centered design;Human Engineering;Iatrogenesis;improved;Incidence;innovation;Interruption;Intervention;Interview;Job Satisfaction;Learning;Maps;Measurement;Measures;Mechanical ventilation;Medication Errors;microsystems;model generalizability;Modeling;mortality;multidisciplinary;multilevel analysis;National Institute of Child Health and Human Development;Neonatal;neonatal care;Neonatal Intensive Care Units;Neonatal Nursing;neonatal patient;neonate;Nosocomial Infections;Nurse Practitioners;Nurses;Observational Study;Occupations;Organ;Patient Care;patient safety;Patient Self-Report;Patient-Focused Outcomes;Patients;Performance;Perioperative;Personal Satisfaction;Physiology;Play;Process;professional atmosphere;prospective;Provider;Psychological Factors;Public Health;Quality of Care;Recommendation;Research;Research Personnel;Resource Allocation;Risk;Role;Safety;safety outcomes;Severities;Shapes;Structure;support tools;Surveys;System;technology intervention;Time;tool;Universities;validation studies;Weight;Work;Workload

PROJECT_TITLE: Measuring NICU Nurse Practitioner Workload in Real-time to Improve Care Quality and Patient Safety

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(91)S]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autism;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Lymphatic Research;Mental Health;Neurodegenerative;Neurosciences;Pediatric;Prevention

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Cerebrospinal fluid (CSF) pathophysiology has been associated with impaired clearance of neuroinflammatory proteins, (e.g., amyloid-beta) and implicated in neurodegenerative disorders such as Alzheimer’s disease, but the role of CSF dynamics in neurodevelopmental disorders remains unknown. This Career Development Award aims to address this gap by elucidating and contrasting trajectories of CSF characteristics in Down Syndrome (DS) and related disorders (autism spectrum disorder and Fragile X syndrome) across the first two years of life, to determine the relationships between CSF physiology and later neural and clinical features. Given that 50% of children with DS will go on to develop early-onset Alzheimer’s, CSF physiology can serve as a mechanistic pathway to aberrant brain and behavioral development and has the potential to guide the design of targeted treatment approaches for early intervention.

PI_NAMEs: GARIC, DEA  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Abeta clearance;Address;Adult;Age Months;Aging;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Animal Model;autism spectrum disorder;Axon;Behavioral;Behavioral Symptoms;Biological Markers;Blood Vessels;Brain;brain health;Brain imaging;career;career development;Cerebrospinal Fluid;cerebrospinal fluid flow;Characteristics;Child;Child Psychiatry;Childhood;Circulation;Clinical;Clinical assessments;Clinical Research;Cognitive deficits;Complex;computer science;critical period;Data;Dedications;Dementia;design;Development;Diffusion;Disease;Disease Progression;Down's Syndrome;early detection biomarkers;Early identification;Early Intervention;Early Onset Alzheimer Disease;Fragile X Syndrome;Functional disorder;Future;General Population;glymphatic clearance;glymphatic dysfunction;glymphatic system;Goals;Health;Human;Image;imaging modality;imaging study;Impairment;improved outcome;infancy;Infant;Intercellular Fluid;Intervention;K-Series Research Career Programs;Lead;Life;Link;Longitudinal Studies;lymphatic drainage;Magnetic Resonance Imaging;Manuscripts;Measures;Meningeal lymphatic system;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Modeling;Morphology;Motor;neural;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;neuroinflammation;Neurology;Neurosciences;Oregon;Outcome;Pathogenesis;Pathology;Pathway interactions;Pediatrics;Physics;Physiology;pre-clinical;programs;Proteins;Protocols documentation;Psychiatry;Radiology Specialty;rapid growth;Research;Research Project Grants;Risk;Role;Sampling;Scanning;Science;Severities;Sleep Disorders;solute;Specificity;Symptoms;targeted treatment;Testing;Training;Treatment Efficacy;Universities;Washington;white matter;Work

PROJECT_TITLE: The Role of CSF Dynamics in Infant Brain and Behavioral Development in Down Syndrome and Related Neurodevelopmental Disorders

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: MILWAUKEE

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Project Narrative The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, we will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.

PI_NAMEs: DURAND, MATTHEW  (contact);HYNGSTROM, ALLISON SUZANNE

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Acetylcholine;Activities of Daily Living;Acute;Affect;Age;Area;Beds;Biological Availability;Blood flow;Blood Vessels;chronic stroke;Clinical;Clinical Trials;Complex;Data;Double-Blind Method;Equilibrium;Exercise;Exposure to;Fatigue;functional gain;Functional impairment;Hyperemia;Impairment;improved;Individual;interest;Intervention;Ischemia;ischemic conditioning;Leg;leg paresis;Lower Extremity;Mediating;Metabolic;Modality;Motor;motor deficit;Motor Neurons;Muscle;Muscle Contraction;Muscle Fatigue;Muscle Weakness;Nerve;neural;Neural Inhibition;Neurologic;neuromuscular;neuromuscular function;Nitric Oxide;Norepinephrine;Oxygen;Paresis;Performance;Perfusion;Persons;Play;post stroke;Process;Randomized;Regulation;rehabilitation strategy;Rehabilitation therapy;Resistance;response;Rest;Role;sex;Skeletal Muscle;Stimulus;Stroke;stroke survivor;Sympathetic Nervous System;Testing;Tissues;Training;Vascular Endothelium;vasoconstriction;Vasoconstrictor Agents;Vasodilation;Vasodilator Agents;Walking;Work

PROJECT_TITLE: Blood Flow Regulation and Neuromuscular Function Post-Stroke

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Innate immune sensing and signaling are important first steps of the immune system to initiate an antiviral response. This study will provide new molecular insight into the host defense mechanisms against herpesvirus infection, which may catalyze the design of novel therapeutic approaches for viral diseases.

PI_NAMEs: GACK, MICHAELA ULRIKE (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Ablation;adaptive immunity;Adjuvant;Anti-viral Response;antiviral immunity;B-Cell Activation;B-Lymphocytes;Binding;Binding Proteins;Biochemical;Biological;Cell Physiology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;cytokine;Cytoplasm;Data;design;Detection;Disease;DNA;Encephalitis;Epithelial Cells;Exhibits;exosome;Family;Fibroblasts;Foundations;Gene Expression;gene-editing approach;Herpes Simplex Infections;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;Heterozygote;Host Defense Mechanism;Human;Immune;Immune system;Immunity;immunodeficiency;Immunology;Impairment;Infection;Innate Immune Response;innate immune sensing;innovation;insight;Interferon Type I;Knowledge;Laboratories;Lead;Ligands;Mediating;Membrane;Missense Mutation;Molecular;Mutation;Natural Immunity;Nature;novel;novel therapeutic intervention;pathogenic virus;Patients;Pattern recognition receptor;Physiological;Play;Polymerase;Population;Protein Biosynthesis;Proteins;Pseudogenes;receptor;response;Ribosomal RNA;RNA;RNA delivery;RNA Polymerase III;RNA Viruses;RNA, Ribosomal, 5S;Role;sensor;Series;Signal Transduction;Toll-like receptors;Transcript;transcription factor;Transfer RNA;unpublished works;Untranslated RNA;Viral;viral DNA;Virus;Virus Diseases;Work

PROJECT_TITLE: Novel Role for Host Immunostimulatory RNA in Antiviral Immune Defense

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]