NIH_SPENDING_CATS: Biomedical Imaging;Cerebrovascular;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PUBLIC HEALTH NARRATIVE The cognitive and mental health burden among virally suppressed people with HIV (VS-PWH) remains a major issue in HIV care. Integrity of the blood brain barrier (BBB) and immune cells migrating into the brain may contribute to neuroinflammation and related neuropsychiatric burden in VS-PWH. To better understand how HIV affects the BBB and the role of neuroinflammation, we will perform brain scans using a novel, noninvasive technique to measure BBB breakdown and tests of cognitive and mental health in a group of VS-PWH and demographically similar HIV-uninfected individuals.

PI_NAMEs: COUGHLIN, JENNIFER MARIE;RUBIN, LEAH HELANE (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;Adherens Junction;Affect;Age;Albumins;ALCAM gene;Alzheimer's Disease;antiretroviral therapy;Area;arterial spin labeling;Baltimore;Biological Markers;Blood;Blood - brain barrier anatomy;Blood Platelets;Blood specimen;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;Brain scan;Caring;CCL19 gene;CCL2 gene;CCL23 gene;CD14 gene;cell motility;Cell Physiology;Cell Separation;Cell Surface Proteins;Cells;Central Nervous System;Cerebrospinal Fluid;chemokine;Chronic;Clinic;Cognition;Cognitive;cognitive testing;Communities;CX3CL1 gene;CXCL9 gene;cytokine;dalton;Development;Diameter;Disabling condition;experience;FCGR3B gene;Fractalkine;Frequencies;Functional disorder;Funding;Health;HIV;HIV Infections;Hospitals;Image;Imaging Device;Imaging Techniques;Immune;Impaired cognition;in vivo;Individual;Infection;inflammatory marker;Infrastructure;innovation;Interleukin-6;Investigation;Link;Lymphocyte;Magnetic Resonance Imaging;Major Depressive Disorder;Measures;Membrane Proteins;Memory impairment;Mental Health;Methods;migration;mild cognitive impairment;Modeling;Molecular;Molecular Weight;monocyte;neuroinflammation;Neurons;neuropsychiatry;Neurotoxins;new therapeutic target;NIH Office of AIDS Research;novel;Outcome;pathogen;Pathogenesis;Peripheral Blood Mononuclear Cell;Persons;Phase;Phenotype;Play;Porosity;Proteins;Public Health;recruit;Research;Role;Sampling;Serum Albumin;Shapes;small molecule;Spinal Puncture;Strategic Planning;Stromal Cell-Derived Factor 1;Supporting Cell;Surface;Techniques;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Tight Junctions;Time;TNF gene;trafficking;Up-Regulation;Vascular Endothelial Growth Factors;Vascular Endothelium;Viral;Water

PROJECT_TITLE: Immune dynamics shaping blood brain barrier integrity in virally suppressed people with HIV


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE  In rodents, diets high in calories, fat, and/or added sugars cause inflammation in brain areas that regulate body weight, leading to overeating and obesity. The proposed research uses magnetic resonance imaging to evaluate the human hypothalamus for signs of inflammation in response to a similar diet. This research may lead to a better understanding of whether poor nutritional quality leads to obesity through effects on body-weight regulating areas of the brain in humans.

PI_NAMEs: SCHUR, ELLEN A (contact)

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: Acute;Adult;adult obesity;Adverse effects;Anatomy;Area;arm;Astrocytes;Blood;Body Weight;Brain;brain control;Brain region;Calories;Carbohydrates;Child;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;Control Groups;Controlled Study;cytokine;Data;design;Development;Diet;diet-induced obesity;dietary;Dietary Factors;Dietary Fats;Disease;Elemental Diets;Energy Intake;Experimental Models;experimental study;Fatty acid glycerol esters;feasibility testing;feeding;Fructose;Future;Gliosis;Glucose;Goals;Health;High Fat Diet;Human;Hyperphagia;Hypothalamic structure;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;Insulin Resistance;insulin sensitivity;Intervention;Investigation;Knowledge;Location;Magnetic Resonance Imaging;Measures;Metabolic Diseases;Metabolic dysfunction;Methods;Microglia;Mission;Modeling;Monitor;MRI Scans;National Institute of Diabetes and Digestive and Kidney Diseases;Neurobiology;Neuroglia;Non-Insulin-Dependent Diabetes Mellitus;Nutritional;Obesity;obesity development;obesogenic;Observational Study;Outcome;Overweight;Participant;Pathogenesis;Play;pre-clinical;preclinical study;Predisposition;preference;Preparation;prospective;Radiology Specialty;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Regimen;Relaxation;Research;Research Personnel;response;Rodent;Rodent Model;Role;Safety;safety outcomes;Sample Size;saturated fat;Saturated Fatty Acids;Serial Magnetic Resonance Imaging;Signal Transduction;Standardization;Stimulus;Structure of nucleus infundibularis hypothalami;sugar;Testing;Theoretical model;Time;Tissues;trial design;Weight;Weight Gain

PROJECT_TITLE: Assessing the effect of diet on hypothalamic gliosis in humans

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative There is accumulating evidence showing that the circadian system plays a critical role in many physical activity-related pathways and regulates the diurnal variations in the cardiometabolic responses to physical activity. This raises the question whether timing may modulate the adaptive responses of physical activity, and can thus be used to enhance the health benefits of physical activity. Here, we aim to test the relationship between timing of physical activity and cardiometabolic outcomes in humans, with the hope of providing mechanistic insights that may assist in the design of lifestyle interventions to improve the efficacy of physical activity.

PI_NAMEs: QIAN, JINGYI  (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Accelerometer;Address;age related;Animals;Area;Autonomic nervous system;Behavioral;Beta Cell;Blood Pressure;Body fat;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;career development;Cell Physiology;Chronobiology;circadian;circadian pacemaker;Clinical Trials Design;combat;Crossover Design;Data;Data Set;Dedications;design;Diabetes Mellitus;disorder risk;Diurnal Rhythm;Energy Intake;Energy Metabolism;Environment;Epidemic;Epidemiology;evidence base;Exercise;exercise intervention;Exercise Physiology;experience;experimental study;Fatty acid glycerol esters;follow-up;Foundations;Frequencies;Funding;Glucose;Glycosylated hemoglobin A;Goals;Health;Health Benefit;Hour;Human;improved;Individual;innovation;insight;insulin sensitivity;Knowledge;Laboratories;laboratory experiment;Laboratory Study;lifestyle intervention;Link;Low-Density Lipoproteins;Mentors;Metabolic Pathway;Metabolism;Modality;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;obese patients;Observational Study;Outcome;Overweight;oxidation;Pathway interactions;Patients;Peripheral Resistance;Persons;Phase;Physical activity;Physiological;Physiology;Play;Prediabetes syndrome;pressure;prevent;primary endpoint;programs;Protocols documentation;Randomized;Randomized, Controlled Trials;Recommendation;Research;Research Design;response;Rest;Risk Reduction;Role;Schedule;secondary endpoint;skills;System;Testing;Time;Tissues;Training;Transcript;Triglycerides;United States National Institutes of Health;Visceral fat;weight loss program

PROJECT_TITLE: Timing of Physical Activity on Cardiometabolic Health Outcomes

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: PROJECT NARRATIVE This award will continue supporting activities of the longstanding Intellectual and Developmental Disabilities Research Center (IDDRC) at the Kennedy Krieger Institute and Johns Hopkins University. The IDDRC's primary goals focus on supporting actively funded research projects targeting intellectual and developmental disorders (IDD) through Cores (Administrative, Clinical Translational Research, Genomics, Neuroimaging, and Behavioral Phenotyping). In addition, the Center directly supports a research project examining the role of sleep, circadian dysfunction, and brain development in children with autism.

PI_NAMEs: FATEMI, S. ALI ;SCHLAGGAR, BRADLEY L (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Address;Advocacy;autism spectrum disorder;autistic children;Award;Basic Science;Behavioral;behavioral phenotyping;biomarker identification;Brain;Center for Translational Science Activities;Circadian Dysregulation;Clinic;clinical care;clinical practice;clinical translation;Cognitive;Collaborations;Communities;comorbidity;Complex;cost;Dedications;Development;Developmental Disabilities;developmental disease;Disability research;Early identification;early screening;Education;Ensure;Etiology;experience;Extramural Activities;Funding;Genomics;Goals;Human;improved;improved outcome;Individual;Infrastructure;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;inter-institutional;Interdisciplinary Study;International;Intervention;Investigation;Knowledge;knowledge translation;Leadership;Link;Maryland;Mentorship;multidisciplinary;National Institute of Child Health and Human Development;Natural History;neurobehavioral;Neurodevelopmental Disability;neuroimaging;Outcome Measure;Patients;Policies;precision medicine;Prevalence;Prevention;programs;Public Health;Public Policy;Research;Research Personnel;Research Priority;Research Project Grants;Resource Sharing;Resources;Role;Schools;Scientific Inquiry;Services;Shapes;Site;Sleep;Sleep Disorders;Strategic Planning;Structure;Time;Training;Translational Research;Translations;Universities

PROJECT_TITLE: Intellectual and Developmental Disabilities Research Centers 2020


NIH_SPENDING_CATS: Brain Disorders;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: MAHONE, ERNEST MARK (contact)

PROJECT_TERMS: Adult;Advisory Committees;behavioral phenotyping;career;Child;Childhood;Clinic;Clinical;Collaborations;Communication;Communities;cost;cost effectiveness;Cost Sharing;Development;Developmental Disabilities;Education;Ensure;experience;Faculty;Fostering;Funding;Goals;Grant;Health;high standard;Human Resources;improved;innovation;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;inter-institutional;International;Knowledge;knowledge translation;Leadership;Medical;meetings;Mission;Morbidity - disease rate;National Institute of Child Health and Human Development;Neurodevelopmental Disability;Neuropsychology;Newsletter;operation;Patients;Policies;Positioning Attribute;Prevention;Process;programs;psychologic;Public Policy;Qualifying;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Science;Scientist;Services;Strategic Planning;Structure;Students;Technology;Training;United States National Institutes of Health;Universities;University resources;Visit;web site

PROJECT_TITLE: ADMINISTRATIVE CORE


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT This study examines how oral Actinobacteria maintain proper folding of virulence factors during their assembly and under stress conditions. A clear understanding of these aspects will provide new targets for anti-infective therapies and prevention of oral biofilm-associated diseases.

PI_NAMEs: TON-THAT, HUNG  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Actinobacteria class;Actinomyces;Address;Adhesives;Affect;Anabolism;Anti-Infective Agents;Attenuated;Bacterial Adhesins;Bacterial Infections;Binding;Biochemical;Bioinformatics;Biological Assay;Cell Physiology;Cell Wall;Cells;Cellular Morphology;Cellular Stress;Compensation;Corynebacterium;Corynebacterium diphtheriae;Coupled;Coupling;Crystallization;Crystallography;Cysteine;Defect;Dental Plaque;Disease;disulfide bond;Electron Transport;Enzymes;Eukaryota;Experimental Models;fitness;Funding;Genetic;genetic approach;Gram-Negative Bacteria;Gram-Positive Bacteria;Guanine + Cytosine Composition;interdisciplinary approach;Isomerase;Isomerism;Knowledge;Mediating;Membrane;Microbial Biofilms;misfolded protein;Modality;Modeling;Molecular;Monobactams;mutant;Mutation;Names;Nematoda;novel;Oral;oral biofilm;Oral Examination;Organism;overexpression;oxidation;Oxidoreductase;Pathway interactions;Penicillin-Binding Proteins;Peptidoglycan;Peptidyltransferase;periplasm;permissiveness;Phase;Pilum;polymicrobial biofilm;prevent;Prevention;Process;Prokaryotic Cells;Protein Export Pathway;protein folding;protein function;protein misfolding;Protein translocation;Proteins;Proteome;public health relevance;rational design;response;Roentgen Rays;Role;Stress;Stress and Coping;Structural Models;Structure;Sulfhydryl Compounds;System;Temperature;Thiol Disulfide Oxidoreductase;TXN gene;Virulence;Virulence Factors;vitamin K epoxide reductase

PROJECT_TITLE: Post-translocational protein folding in Gram-positive bacteria


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: FATEMI, S. ALI  (contact)

PROJECT_TERMS: Adult;Advocacy;Animal Behavior;Animal Model;Animals;Applications Grants;Autopsy;Basic Science;Biochemical;Biochemistry;Biological Assay;Biometry;Breeding;career;Cell Culture Techniques;Certification;Child;Childhood;Clinic;Clinical;Clinical Laboratory Improvement Amendments;Clinical Research;clinical translation;Clinical Trials;Collaborations;Communities;Conduct Clinical Trials;Consultations;design;Development;Developmental Disabilities;developmental disease;Disease;Educational Activities;Enzymes;experience;Faculty;falls;Fibroblasts;Follow-Up Studies;Funding;Genotype;Goals;Grant Review;Histology;Human;human induced pluripotent stem cells;IACUC;improved;improved outcome;In Vitro;Industry;Infrastructure;innovation;Institutional Review Boards;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Knowledge;Laboratories;Lipids;live cell imaging;Marketing;Mass Spectrum Analysis;Medical Students;member;Mentors;Metabolic;Methods;Microscopy;Microsurgery;Molecular;Movement;National Institute of Child Health and Human Development;neurobehavioral test;Neurodevelopmental Disorder;Neurons;neurophysiology;Operative Surgical Procedures;Pathogenesis;Phenotype;Policy Maker;pre-clinical;Prevention;programs;Protocols documentation;Public Policy;Research;Research Methodology;Research Personnel;Resources;Rodent;Services;symposium;tandem mass spectrometry;Technology Transfer;Training;Transgenic Animals;translational model;translational neuroscience;Translational Research;Translations;Universities

PROJECT_TITLE: CLINICAL TRANSLATIONAL CORE


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: This research proposal will inform public health decisions, as our findings will transform how clinicians and scientists think about neurodegeneration in Parkinson's Disease and Parkinsonism's. Understanding factors that render cells vulnerable to degeneration and the common and distinct mechanisms of molecular dysregulation underlying the disease states, particularly among inherited or familial subtypes, will increase the accuracy and precision to predict risk, improve diagnosis and establish a new framework for innovative therapeutic strategies in line with the mission of the NIH to improve the human condition.

PI_NAMEs: BLANCHARD, JOEL WILLIAM (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Affect;American;Autopsy;autosome;biological adaptation to stress;Biological Models;Brain;Candidate Disease Gene;candidate identification;candidate validation;Caregivers;Cell Death;Cell Line;Cell model;Cell Physiology;cell type;Cells;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Correlation Studies;CRISPR-mediated transcriptional activation;Data;Data Set;Diagnosis;Disease;disease model;disorder risk;DNA Damage;Dopamine;dopaminergic neuron;early onset;Environment;Flow Cytometry;Fluorescent Dyes;Functional disorder;Gene Expression;Genes;Genetic;Genotype;Goals;Human;human pluripotent stem cell;Hypothalamic structure;Image;improved;Individual;Inherited;innovation;insight;knock-down;Knock-in;Knowledge;Lentivirus Vector;Lipids;loss of function;Mendelian disorder;Metabolism;Midbrain structure;Mission;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;molecular subtypes;motor impairment;multiple omics;Mutagenesis;Mutation;Nerve Degeneration;Neurons;new therapeutic target;novel;novel strategies;Organoids;Outcome;Oxidative Stress;Oxidative Stress Pathway;PARK7 gene;PARK9 gene;Parkinson Disease;Parkinsonian Disorders;Pathologic;Pathology;Pathway Analysis;Pathway interactions;patient stratification;Patients;Pattern;pharmacologic;Phenotype;Population;Population Analysis;Prevention;Prevention strategy;Printing;Prosencephalon;protein aggregation;Proteins;Proteomics;Public Health;Reactive Oxygen Species;Reporter;Research;Research Proposals;response;risk prediction;Scientist;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Source;sporadic Parkinson's Disease;System;Technology;Testing;Therapeutic;Time;Tissues;tool;trafficking;transcriptomics;Tyrosine 3-Monooxygenase;United States National Institutes of Health

PROJECT_TITLE: Understanding Cell-type Vulnerability and Oxidative Stress Pathology in Parkinson's Disease Using Isogenic Human Dopaminergic Neurons

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Sleep Research

PI_NAMEs: MOSTOFSKY, STEWART H (contact)

PROJECT_TERMS: 12 year old;actigraphy;Acute;Adaptive Behaviors;Address;Adult;Affect;analytical method;Area;Attention;autism spectrum disorder;autism symptoms;autistic children;Behavior;Behavioral;behavioral phenotyping;Biological;Biological Markers;Biometry;Brain;brain based;brain behavior;brain health;Child;circadian;Circadian Dysregulation;Clinical;clinical practice;Cognition;Cognitive;Data;Detection;Development;Developmental Disabilities;Diagnosis;Elements;Enrollment;Epidemiology;Etiology;executive function;Exhibits;Goals;Hour;Impairment;improved;improved outcome;indexing;innovation;innovative technologies;Intellectual and Developmental Disabilities Research Centers;Intervention;Link;Literature;Machine Learning;Measurement;Measures;Mediating;Methodology;Methods;Modeling;Motor Activity;neurobehavioral;neuroimaging;novel;Outcome;Outcome Measure;Parents;Pattern;personalized intervention;Phase;Phenotype;poor sleep;Population;Precision therapeutics;Preparation;Prevention;prevention practice;Procedures;Questionnaires;Reporting;Research;Research Project Grants;Resources;Rest;Role;Sample Size;Sampling;School-Age Population;Severities;Sleep;sleep behavior;Sleep Disorders;Sleep disturbances;sleep onset;social;Statistical Models;Structure;Symptoms;Thick;Time;Universities;Work;Wrist;Youth

PROJECT_TITLE: Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in Autism


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: PEVSNER, JONATHAN  (contact)

PROJECT_TERMS: Accreditation;Applications Grants;Area;biobank;Bioinformatics;Biological Assay;Cell Line;Certification;ChIP-seq;Clinical;Clinical Services;cluster computing;Code;Computers;computing resources;Consultations;Cytogenetics;Data;Data Analyses;data sharing;Databases;density;Detection;Developmental Delay Disorders;Developmental Disabilities;digital;DNA;DNA Sequence Alteration;E-learning;education resources;Educational Activities;Educational process of instructing;Educational workshop;Equipment;established cell line;Etiology;exome;experience;Faculty;Fostering;Genetic;genome sequencing;genome wide association study;genomic data;Genomic Library;Genomics;Genotype;Goals;graduate medical education;Guidelines;Human Genetics;Human Subject Research;Individual;Informed Consent;insertion/deletion mutation;Institutional Review Boards;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;Internships;Investments;Knowledge;Laboratories;Laboratory Research;Learning Module;Master of Science;Methylation;Microarray Analysis;Mission;Molecular;Mycoplasma;nano-string;nanopore;Natural History;next generation sequence data;next generation sequencing;Nucleotides;Phenotype;Phylogeny;Preparation;Production;Prognosis;protocol development;Protocols documentation;pyrosequencing;repository;Reproducibility;Research;Research Design;Research Personnel;Resources;RNA;RNA Interference;Rotation;Sequence Alignment;Services;single cell ATAC-seq;single cell genomics;single molecule;Specimen;Technology;Testing;tissue culture;Training;Training Programs;transcriptome sequencing;United States National Institutes of Health;Universities;user-friendly;Variant;variant of unknown significance;web services;whole genome

PROJECT_TITLE: GENOMICS CORE


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Post-Traumatic Stress Disorder (PTSD);Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE: Posttraumatic stress disorder (PTSD) has pervasive and detrimental neurobiological and psychological consequences, and PTSD prevalence rates as high as 30-50% are observed among civilians living in areas with high violence. In addition, children of mothers with posttraumatic symptoms (PTS) are at increased risk for stress-related psychological disorders thereby promoting a cycle of intergenerational transmission of stress reactivity. The ultimate goal of this proposal is to combine clinical and developmental psychopathology research and basic neuroscience research to establish a mechanistic model of intergenerational PTS risk that can be translated into clear treatment targets in at-risk mothers and their children.

PI_NAMEs: LOTT, ABIGAIL POWERS (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Affect;Amygdaloid structure;Area;Arousal;Behavior;Behavioral;Biological;Caring;Child;Child Rearing;Clinic;Clinical;Crying;Cues;Data;Development;Discipline of obstetrics;Distress;emotion dysregulation;emotion regulation;Emotional;emotional experience;Emotions;Environmental Risk Factor;Face;flexibility;Fright;Functional impairment;Functional Magnetic Resonance Imaging;Future;Galvanic Skin Response;Goals;Gynecology;Health;Heart Rate;Hydrocortisone;Hyperactivity;Impairment;infancy;Infant;infant outcome;Informal Social Control;Infrastructure;insight;Insula of Reil;intergenerational;Intervention;Life;Link;Longitudinal Studies;maternal caregiving;Measures;men;Mental disorders;Modeling;Mother-Child Relations;Mothers;negative affect;neural;Neurobiology;Neurosciences Research;Newborn Infant;Outcome;parent project;Pathology;Pattern;Physiological;Physiology;Population;Post-Traumatic Stress Disorders;post-traumatic symptoms;Postpartum Period;Postpartum Women;Prefrontal Cortex;Prevalence;psychologic;Psychopathology;Recovery;recruit;Regulation;repaired;Research;resilience factor;respiratory;response;Risk;Risk Factors;Role;Secure;Signal Transduction;Sinus Arrhythmia;Social Development;Stimulus;Stress;stress reactivity;stressor;System;Testing;Translating;transmission process;Trauma;trauma exposure;Violence;Woman

PROJECT_TITLE: Mechanistic links between maternal PTSD and early infant emotional development


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: VAN ZIJL, PETER CM (contact)

PROJECT_TERMS: Anatomy;Animal Model;Biomedical Engineering;Brain imaging;Clinical Services;clinically significant;Communities;Computer software;computerized data processing;Computers;Consultations;Data;Data Analyses;Data Set;Data Storage and Retrieval;Dedications;design;Development;Education;Environment;experience;Faculty;Functional Magnetic Resonance Imaging;Funding;Goals;Grant;Human;Image;image processing;imaging science;Industry;Infrastructure;innovation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;Magnetic Resonance;Magnetic Resonance Imaging;meetings;Methodology;Methods;mid-career faculty;Mission;Neurodevelopmental Disorder;neuroimaging;Neurology;novel;novel imaging technology;novel strategies;operation;Participant;Phenotype;Physiologic pulse;Physiological;Prevention;Procedures;Process;Progress Reports;Quality Control;Radiology Specialty;Research;Research Design;Research Personnel;Resources;Scanning;Scheme;Scientist;senior faculty;Sequence Analysis;Services;Stimulus;Students;symposium;synergism;Techniques;Technology;tool;Training;training opportunity;transcranial direct current stimulation;Transcranial magnetic stimulation;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: NEUROIMAGING CORE


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PROJECT_TERMS: Adherence;Affect;Agreement;Assessment tool;associated symptom;Behavior;Behavior assessment;Behavioral;behavioral phenotyping;Biological Markers;biomarker identification;Brain;Caregivers;Catalogs;Child;Clinic;Clinical;clinical outcome measures;clinical trial readiness;Clinical Trials;Cognition;cognitive development;Communication impairment;Communities;Data;Databases;Development;Diagnostic;early screening;Electroencephalography;Eligibility Determination;Equipment;Esthesia;Faculty;Functional disorder;Functional Magnetic Resonance Imaging;Genetic Diseases;Human;Image;Impairment;Individual;Infrastructure;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Intervention;Link;Measurement;Medical;Medical History;Medical Students;Mentors;Methods;Motion;Motor;motor impairment;Movement;National Institute of Child Health and Human Development;Natural History;Neurocognitive;Neurodevelopmental Disorder;neuroimaging;Neurologic;neurophysiology;Neuropsychology;Outcome;Participant;Performance;Phenotype;phenotypic data;Physiological;Play;Policy Maker;Polysomnography;Procedures;Proprioception;Registries;remote assessment;Research;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Resources;Robotics;Role;Scientific Inquiry;screening;Sensory impairment;Services;Technology Assessment;Testing;Training;treatment effect;Validation;wearable device

PROJECT_TITLE: BEHAVIORAL PHENOTYPING CORE


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Throughout life, the cerebellum calibrates both reflexes and learned movements, and is required for our most fundamental daily activities, ranging from writing to walking and speaking. This calibration requires a form of learning that has traditionally been thought to be guided by movement errors. We propose to test a new model of cerebellar learning based on predictions about reward that could enable learning to be guided by principles of reinforcement.

PI_NAMEs: HULL, COURT A (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Association Learning;Automobile Driving;Behavior;Behavioral;Behavioral Paradigm;Binding;Calcium;Calibration;Cerebellar Cortex;Cerebellum;Conditioned Stimulus;Cues;Data;Dendrites;dopaminergic neuron;Educational process of instructing;Electrodes;Evaluation;experimental study;extracellular;Fiber;fiber cell;Future;Generations;granule cell;Image;in vivo calcium imaging;Instruction;Learning;learning strategy;Life;Link;Measures;Mediating;Modeling;Monitor;mossy fiber;Motor;motor control;motor learning;Motor output;Movement;Mus;optogenetics;Outcome;Output;Pathway interactions;Play;postsynaptic;predictive modeling;Probability;Property;Psychological reinforcement;Purkinje Cells;Reflex action;Reporting;response;Response to stimulus physiology;reward anticipation;Rewards;Signal Transduction;Site;Specificity;Stimulus;supervised learning;Synapses;System;Testing;theories;Thinking;Training;transmission blocking;two-photon;Ventral Tegmental Area;Visualization;Walking;Work;Writing

PROJECT_TITLE: Cerebellar circuits for reward-based learning

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE  Sociodemographic changes and revised US Census questions have led to new recognition of the growth in the proportion of people self-identifying as biracial. However, despite calls from NIDA for etiological research to inform primary prevention of adolescent substance use, little is known about substance use among biracial youth. The proposed research aims to provide information critical to both the speedy refinement of existing programs and the creation of targeted programs for biracial adolescents and emerging adults. 1

PI_NAMEs: GOINGS, TRENETTE CLARK (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;adolescent substance use;Adult;Affect;Age;Age of Onset;Alaska Native population;Alcohol consumption;American;American Indian Population;American Indians;Asian;Asian Americans;Asian population;Behavioral;biracial;Black American;Black race;black subgroup;Buffers;Categories;caucasian American;Caucasians;Censuses;Child Rearing;cigarette smoking;Clinical;clinically relevant;Communities;Data;Data Analyses;Data Set;Databases;Development;deviant peer;emerging adult;emerging adulthood;Ethnic Population;Etiology;Exhibits;experience;Exposure to;Face;Family;Future;General Population;Growth;Guide prevention;Health;High Prevalence;high risk;high school;Hispanic;improved;Individual;insight;Intervention;intervention program;junior high school;Literature;Lived experience;Longitudinal Studies;marijuana use;Measures;Mental Health;Minority;Modeling;Monitor;multi-racial;multiple drug use;National Institute of Drug Abuse;Outcome;Parent-Child Relations;Pattern;peer;Peer Pressure;perceived discrimination;Persons;Phase;physical conditioning;Population;Prevalence;Prevention;Prevention approach;Prevention program;Primary Prevention;Principal Investigator;programs;protective factors;Public Health Practice;Race;racial population;Research;Risk;Risk Behaviors;Risk Factors;risk mitigation;Sample Size;Sampling;Schools;Science;self esteem;Severities;social health determinants;Socialization;sociodemographics;Speed;Students;Subgroup;substance use;substance use prevention;Testing;Translating;Translations;Violence;Work;Youth

PROJECT_TITLE: Substance Use among Biracial Adolescents and Emerging Adults: The Double Jeopardy Hypothesis

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Health disparities in the burden of multiple chronic conditions in the Chicago region are attributed to a history of racial segregation leaving gaps in economic opportunities and gaps in the healthcare system. The Chicago Chronic Condition Equity Network (C3EN) will address these gaps by strengthening and building collaborations across community-based organizations, practice networks, and academic researchers, by promoting a comprehensive approach to the prevention and management of multiple chronic conditions that accounts for mental health, functional health and social life, and by supporting interventions that actively seek to cross boundaries of disease-specific management, professional training, community and practice.

PI_NAMEs: HUANG, ELBERT S. (contact);LYNCH, ELIZABETH B

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Academic Medical Centers;Address;Ambulatory Care;Body System;cardiometabolism;Caring;Charge;Chicago;Chronic;Collaborations;Communication;Communities;community based research;Community Healthcare;community organizations;community setting;County;critical period;Dementia;Diabetes Mellitus;Disease;Disparity;disparity reduction;Economics;Education;Equity;ethnic minority population;evidence base;experience;Federally Qualified Health Center;Foundations;Funding;Geography;Grant;Health;health care service;health care service organization;Health Disparities Research;health disparity;health goals;health professional shortage areas;Health Resources;Healthcare Systems;HIV;Home;implementation science;improved;Individual;individual patient;Informatics;innovation;Institution;inter-institutional;Interdisciplinary Study;interest;Intervention;Knowledge;Life;Low income;Malignant Neoplasms;medical specialties;Mental Health;Mentors;Modeling;multiple chronic conditions;Neighborhoods;Network-based;opioid use;Outcome;Persons;Pilot Projects;Poverty;prevent;Prevention approach;Preventive;Primary Health Care;psychologic;Public Health;Quality of Care;racial minority population;Racial Segregation;Recording of previous events;remote sensor;Research;Research Personnel;Research Project Grants;Research Support;Resources;safety net;Science;sensor technology;Services;social;Social Functioning;social health determinants;software systems;System;Time;Training;Training Programs;translational medicine;Translational Research;United States National Institutes of Health;Universities


NIH_SPENDING_CATS: Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: HUANG, ELBERT S. (contact)

PROJECT_TERMS: Advisory Committees;Area;Chicago;Chronic;Chronic Disease;Cities;Collaborations;Communication;Communities;community advisory board;community engagement;community organizations;data integration;data sharing;Dedications;Development;Doctor of Philosophy;Effectiveness;Ensure;Equity;Evaluation;Fostering;Funding;Future;Goals;Grant Review;health disparity;health equity;Health Sciences;implementation science;Informatics;Institution;Intervention;Leadership;Logistics;meetings;member;Mission;Modeling;multiple chronic conditions;operation;Performance;Pilot Projects;Prevention;Process;Productivity;Program Sustainability;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;statistics;Strategic Planning;Study Section;suburb;Technical Expertise;Universities;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Boulder

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Skeletal muscle is essential for life, with reductions in muscle health during aging or in muscle diseases contributing to loss of life quality, morbidity that overburden our health care. Understanding how muscle health is improved from altering muscle stem cells is the central goal of our proposal.

PI_NAMEs: OLWIN, BRADLEY B (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Address;Affect;age related;Aging;Automobile Driving;Basal lamina;Cell Count;Cell Cycle;Cell Maintenance;Cell Physiology;Cells;Complex;Coupled;Data;Daughter;daughter cell;Dependence;Elements;Epidermal Growth Factor Receptor;experimental study;FGFR1 gene;Goals;Health;Health Care Costs;Healthcare;Hospitalization;improved;Injury;Knowledge;Life;MAP Kinase Gene;Mediating;Messenger RNA;Minor;Modeling;Morbidity - disease rate;Mus;Muscle;muscle aging;Muscle function;muscle progenitor cell;Muscle satellite cell;mutant;Mutate;Myoblasts;Myopathy;Neuromuscular Diseases;Nuclear;old mice;p38 Mitogen Activated Protein Kinase;Pathway interactions;patient home care;Performance;Phenotype;Physiological;polarized cell;Population;postmitotic;Proliferating;Quality of life;receptor;Receptor Signaling;Research;Role;self-renewal;Signal Pathway;Signal Transduction;Signaling Protein;single cell sequencing;Skeletal Muscle;skeletal muscle wasting;Source;stem cell population;stem cells;Testing;therapeutic development

PROJECT_TITLE: Replicative Potential of Muscle Stem Cells

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_DEPT: NUTRITION

PHR: Project Narrative Cardiometabolic diseases currently pose one of the biggest threats to health and development globally, particularly in low- and middle-income countries. Despite calls from expert panels, little progress has been made in reducing this disease burden. We propose a nutrition-focused interdisciplinary predoctoral program to train leaders with expertise across global cardiometabolic disease biology, epidemiology, social, and environmental determinants that will translate to effective individual and global policy prevention strategies.

PI_NAMEs: ADAIR, LINDA S (contact);GORDON-LARSEN, PENNY

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Cardiometabolic Disease;Training

PROJECT_TITLE: Global Cardiometabolic Disease Training

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BAIG, ARSHIYA AHMED (contact)

PROJECT_TERMS: Academic Medical Centers;Area;Award;Biomedical Research;Biometry;Budgets;career;career development;Chicago;Chronic;Chronic Disease;Cities;Collaborations;Communities;community academic partnership;community collaboration;community involvement;community organizations;community partners;Consultations;Data;Data Science;Dedications;design;Development;disease disparity;Disparity;Equity;experience;Focus Groups;Foundations;Funding;Future;Geographic Locations;Goals;Government Agencies;Grant;Health;Health Disparities Research;health disparity;Infrastructure;innovation;Institution;Intervention;Leadership;Measures;meetings;Mentors;Mentorship;Methodology;Mission;Monitor;Needs Assessment;next generation;novel;Performance;Pilot Projects;Process;programs;Publishing;racial health disparity;Religion;Request for Applications;Research;Research Activity;Research Personnel;Research Project Grants;research study;Research Support;Resources;Series;Side;socioeconomics;Solid;Study Section;success;Time;timeline;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Investigator Development Core


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE A national challenge in the biomedical sciences is to recruit, train, and retain the broadest and most diverse scientific talent pool possible. At the University of Utah, we are poised to tackle this challenge by leveraging our recent successes in recruiting underrepresented students into our graduate programs and redoubling our efforts on the postbaccalaureate population. We will establish the Intermountain Postbaccalaureate Research Education Program and solidify key relationships with our local community and Historically Black Colleges and Universities to foster an inclusive, research-intensive environment where underrepresented scientists can flourish and attain their goal of admission to top-notch PhD training programs.

PI_NAMEs: BABST, MARKUS ;FAIRFAX, KEKE CELESTE;MURTAUGH, LEWIS C (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Admission activity;Biological Sciences;Biomedical Research;career;Career Choice;career networking;college;Communication;Communities;Critical Thinking;cultural competence;Dedications;design;Development;Development Plans;Disadvantaged;Discrimination;Doctor of Philosophy;doctoral student;Early Intervention;education research;Educational workshop;empowerment;Enrollment;Environment;equity, diversity, and inclusion;expectation;experience;Extramural Activities;Faculty;Family;Fellowship;Fortification;Fostering;Funding;Future;Goals;Graduate Degree;Graduate Education;graduate school;Historically Black Colleges and Universities;Immersion;Individual;Infrastructure;innovation;Institution;Knowledge;Lead;Leadership;Learning;Life;matriculation;meetings;member;Mentors;Minority-Serving Institution;Mission;notch protein;Oral;peer;peer support;Personal Satisfaction;Population;Population Heterogeneity;Positioning Attribute;Postbaccalaureate;posters;Privatization;Process;programs;Readiness;recruit;Research;Research Project Grants;Research Training;resilience;role model;Science;Scientist;Self Efficacy;Shapes;skills;social;stem;Student recruitment;Students;success;Support System;Syndrome;Talents;Technical Expertise;tool;Training;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Utah;Workplace;Writing

PROJECT_TITLE: Intermountain PREP

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Patient Safety;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: Aurora

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE This study seeks to provide large-scale, foundational evidence that high-intensity rehabilitation is effective and can be systematically implemented to improve functional outcomes for patients admitted to skilled nursing facilities following hospitalization. Additionally, this study will generate a descriptive overview of factors that predict implementation success while informing effective implementation strategies for future skilled nursing facilities innovation. Overall, this study is a critical step in advancing clinical practice to establish high-intensity rehabilitation as an effective standard of care in skilled nursing facilities to shift current treatment away from low-intensity, conservative interventions.

PI_NAMEs: STEVENS-LAPSLEY, JENNIFER E. (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Activities of Daily Living;Acute;acute care;Address;Admission activity;Adopted;Adoption;Adult;Adverse event;appropriate dose;Behavioral;Cessation of life;Characteristics;Client satisfaction;Clinical;clinical practice;Communities;community setting;Complex;contextual factors;cost effective;Country;Data;deconditioning;Deterioration;disability;Dose;Education;Effectiveness;effectiveness evaluation;Eligibility Determination;Evaluation;Event;experience;functional improvement;Future;Gait speed;Health;Home;hospital readmission;Hospitalization;human old age (65+);implementation context;implementation facilitators;implementation strategy;improved;improved outcome;indexing;innovation;insight;Institutionalization;Instruction;Intervention;Length of Stay;Long-Term Care;Maintenance;Measures;Medical;Methods;muscle strength;Musculoskeletal;Nursing Homes;nursing skill;older adult;Outcome;Patient Admission;Patient Discharge;Patient-Focused Outcomes;Patients;Phase;Physical activity;Physical Function;Physical Performance;Physiological;poor communities;Population;pragmatic randomized trial;pragmatic study;Predictive Factor;pressure;primary endpoint;primary outcome;Process;provider adoption;Quality of Care;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;readmission rates;rehabilitation paradigm;rehabilitation strategy;Rehabilitation therapy;rehabilitative care;Resistance;resistance exercise;Site;Skeletal Muscle;Skilled Nursing Facilities;standard of care;Standardization;success;theories;Therapeutic;Time;Training;treatment as usual;trial design;Variant;Work

PROJECT_TITLE: Advancing Rehabilitation Paradigms for Older Adults in Skilled Nursing Facilities

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MILLER, DORIANE CLARICE (contact)

PROJECT_TERMS: Address;African American;Area;Caring;Catchment Area;Chicago;Chronic;Chronic Disease;Cities;Clinical;Clinics and Hospitals;Collaborations;Communities;community based research;community engagement;Community Health;Community Healthcare;Community Hospitals;Community Networks;community organizations;community partners;community partnership;County;critical period;Disparity;Equity;ethnic minority population;evidence base;Faith-based organization;Foundations;Geography;Health;health care delivery;health care service;Health Disparities Research;health disparity;health equity promotion;health inequalities;Health Personnel;Health Resources;Health system;Healthcare;Healthcare Systems;Hispanic;holistic approach;Illinois;improved;Income;Inequity;Intervention;Latinx population;Life;Low income;Maps;member;multiple chronic conditions;Neighborhood Health Center;Neighborhoods;novel;Outcome;Poverty;Preventive;Process;Public Health;racial minority population;Racial Segregation;Recording of previous events;Research;Research Design;Research Personnel;Science;Services;Side;Silver;social;social health determinants;Structure;suburb;System;Universities;Voice;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Kidney Disease;Patient Safety;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Candidate: Kurella Tamura, Manjula PROJECT NARRATIVE The proposed K24 Midcareer Investigator Award ‘A Mentoring Program in Kidney Care for Older Adults’ will support a multi-disciplinary research program and train the next generation of patient-oriented researchers. Building on a track record of successfully mentoring junior investigators, this proposal will enable the candidate to dedicate more time to mentoring trainees, gain new skills that will expand the scope of her research, and conduct new research that will extend evidence from large clinical trials in hypertension and kidney disease to evaluate the comparative risks and benefits of intensive blood pressure targets in real world older adults.

PI_NAMEs: KURELLA TAMURA, MANJULA  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adult;Advance Care Planning;Affect;Age;Aging;antagonist;Anti-Hypertensive Agents;Area;Award;Benefits and Risks;Blood Pressure;cardiovascular risk factor;Cardiovascular system;career;career development;Caring;Cessation of life;Chronic Kidney Failure;clinical center;Clinical Trials;cohort;comparative;Data;Decision Analysis;Dedications;Dialysis procedure;Diastolic blood pressure;Discipline;Disease Management;Disease Progression;Education;Elderly;Electrolyte Disorder;Electronic Health Record;Event;experience;Fostering;Frail Elderly;Funding;Future;Glucose;Goals;Grant;Guidelines;Health Services;Hypertension;hypertension treatment;Impaired cognition;inhibitor;Interdisciplinary Study;Intervention;Investigation;Journals;Kidney;Kidney Diseases;Knowledge;Mentors;Methodology;Methods;Midcareer Investigator Award in Patient-Oriented Research;Mineralocorticoid Receptor;Modeling;mortality;multidisciplinary;next generation;novel;novel strategies;Nursing Homes;older adult;Outcome;patient oriented;patient population;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Policies;Policy Maker;Population;Positioning Attribute;profiles in patients;Program Sustainability;programs;Publishing;Pulse Pressure;randomized trial;Recommendation;Renal function;Renin-Angiotensin-Aldosterone System;Research;Research Personnel;Research Project Grants;Research Support;Resources;Risk Reduction;Scientist;Serious Adverse Event;Shapes;skills;Sodium;Structure;Study models;symporter;Systolic Pressure;Target Populations;Time;tool;Training;training opportunity;Training Programs;treatment effect;United States Department of Veterans Affairs;Universities;Work

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Physical Rehabilitation;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

PI_NAMEs: LYNCH, ELIZABETH B (contact)

PROJECT_TERMS: Acceleration;Accelerometer;Address;Admission activity;Adoption;Adult;African American;African American population;Age;Automobile Driving;Black church;Cessation of life;Chicago;Chronic;Chronic Disease;Church;Clinical;clinically significant;Collaborations;Communities;community based participatory research;community intervention;Development;disability;disability risk;Disparity;Dyspnea;Education;Elderly;Equity;evidence base;exercise intervention;experience;Faith;falls;Feasibility Studies;Fellowship;Fright;Future;group intervention;Health;Health Care Costs;health equity;High Prevalence;Hispanic Populations;Hospitalization;Impairment;implementation intervention;improved;Individual;Injury;Intervention;Intervention Studies;Life Expectancy;lifestyle intervention;Lower Extremity;Maintenance;Measures;member;Mental Health;middle age;Mobility decline;Mobility disability;Morbidity - disease rate;mortality;mortality risk;multi-site trial;multiple chronic conditions;Names;Not Hispanic or Latino;Nursing Homes;older adult;Outcome;Pain;Participant;Patient Self-Report;Persons;Physical activity;Physical Function;Pilot Projects;prevent;programs;Quality of life;racial disparity;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Rehabilitation therapy;Reporting;Research;Research Personnel;Risk;Risk Reduction;Sampling;satisfaction;screening;Self Efficacy;sex;Side;social;Social support;Specialist;Strenuous Exercise;Structure;Symptoms;Testing;Translating;Trust;virtual;Walking;walking intervention;walking program;Work

PROJECT_TITLE: Keep it Movin': A Church-based Intervention to Improve Physical Function in African Americans


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Hirschsprung disease (HSCR) is congenital gastrointestinal condition affecting 1 in 5,000 infants that is characterized by the absence of an enteric nervous system (ENS) in the distal intestine. Even after surgery to remove the distal intestine, there is significant bowel dysfunction in the remaining intestine, highlighting the imperative to identify the key cellular and molecular drivers of ongoing intestinal dysfunction. As an aspiring pediatric surgeon-scientist, my goal is to leverage the K08 mechanism to provide a foundation for my independent academic career and to explore my central hypothesis that biomechanical forces trigger dysregulation of the intestinal extracellular matrix (ECM) microenvironment, which in turn alters the behavior of the ENS and ultimately drives gut dysfunction.

PI_NAMEs: CHENG, LILY S (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Advisory Committees;Affect;Award;Behavior;biomechanical test;Biomechanics;Calcium;career;Caring;Cell Adhesion Molecules;cell behavior;Cells;Characteristics;Childhood;Clinical;Clinical Investigator Award;clinically relevant;Colon;Colonic Diseases;Congenital Disorders;Congenital Megacolon;Constipation;Data;Deposition;Development;Diagnostic;Disease;Distal;distraction;Education;Enteral;Enteric Nervous System;Enterocolitis;Etiology;Excision;experimental study;Extracellular Matrix;Failure;Fecal Incontinence;Focal Adhesion Kinase 1;Focal Adhesions;Foundations;Functional disorder;gain of function;gastrointestinal;Gastrointestinal tract structure;Goals;Growth;Human;Hydrogels;Image;improved;In Vitro;in vivo;Incidence;Infant;innovation;Intestinal Diseases;Intestines;Investigation;Ion Channel;Laboratories;Logic;loss of function;mechanical force;Mechanics;Mediator;Mentors;Methodology;Modeling;Molecular;nervous system development;Nervous System Physiology;Neuronal Dysfunction;neuronal survival;Neurons;Neurotransmitters;new therapeutic target;novel;Operative Surgical Procedures;Outcome;Patients;Pediatric Hospitals;Phenotype;Piezo 1 ion channel;postnatal;Postoperative Period;Prevalence;Prognosis;prognostic tool;Proliferating;Quality of life;Radial;Research;response;risk prediction model;Role;Scientist;Signal Transduction;skills;Stretching;Structure;Surgeon;Technical Expertise;Techniques;Testing;Texas;tissue culture;Tissues;translational impact;Work

PROJECT_TITLE: Investigating the role of biomechanical forces on the enteric nervous system in Hirschsprung disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK(M1)-1-C]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cannabinoid Research;Clinical Research;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Tobacco use is the leading preventable cause of death, accounting for 1/3 of all cancer deaths. There are significant disparities in tobacco-induced cancer morbidity and mortality and reducing this disparate burden of disease requires understanding how the tobacco industry attempts to influence regulation, conduct target marketing, and oppose the diffusion innovative local and state level policies that promote health equity.

PI_NAMEs: BIALOUS, STELLA AGUINAGA (contact);LING, PAMELA MAY

PROGRAM_OFFICER_NAME: KAUFMAN, ANNETTE R

PROJECT_TERMS: Accounting;Address;Ally;burden of illness;Businesses;Cannabis;Cannabis policy;Cause of Death;Cessation of life;Collaborations;Communication;Communities;Devices;Diffusion;Diffusion of Innovation;Disease;Disparity;disparity reduction;Educational Status;Electronic cigarette;Electronics;Environment;ethnic minority;Ethnic Origin;experience;Face;Future;Gender;Harm Reduction;health disparity;health equity;health equity promotion;Health Policy;Health Professional;Hearing;heated tobacco products;Housing;Industry;Inequity;informant;innovation;Intervention;Interview;JUUL;Legitimacy;Libraries;Malignant Neoplasms;Marketing;Minority;minority communities;Minority Groups;Modeling;Morbidity - disease rate;mortality;Motivation;news;Nicotine;nicotine use;novel;Parents;Pharmacologic Substance;Policies;Policy Maker;Politics;Positioning Attribute;Poverty;programs;Provider;Public Health;public policy on tobacco;Publishing;Race;racial minority;Reduce health disparities;Regulation;Reporting;Research;Research Personnel;Resources;Risk;Sales;Sex Orientation;Smoking;social;theories;Tobacco;tobacco advertising;tobacco control;tobacco flavor;Tobacco Industry;tobacco products;Tobacco use;Tobacco-Related Carcinoma;vaping;Vaporizer;vector;Vulnerable Populations;Work

PROJECT_TITLE: Addressing disparities in tobacco-related diseases by understanding the tobacco industry strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-N(02)]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Adoption;Adult;Advocate;Affect;African American;African American population;Amputation;Appointment;Area;Black race;Blood Glucose;Blood Pressure;Body mass index;Cardiovascular Diseases;Caring;Chicago;Chronic;Chronic Kidney Failure;Clinic;Clinical;clinical care;clinical research site;Cluster randomized trial;Color;Communities;Community Health;Community Health Networks;comorbidity;Complex;Complications of Diabetes Mellitus;Comprehensive Health Care;COVID-19 pandemic;diabetes management;Diabetes Mellitus;Diet;Education;Effectiveness;effectiveness/implementation design;effectiveness/implementation hybrid;Enrollment;Equity;Federally Qualified Health Center;glycemic control;Glycosylated Hemoglobin;Health;health care service utilization;Health Personnel;Health system;Heart Diseases;Hispanic;Hispanic Americans;Hispanic Populations;Hospitals;Hypertension;Illinois;implementation evaluation;implementation facilitators;implementation outcomes;improved;Individual;Intervention;Interview;Kidney Diseases;Latino;Learning;Low income;Maintenance;Medical;medically underserved;Mental Depression;metropolitan;Midwestern United States;Modeling;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Outcome;Patient Appointment;Patients;peer;people of color;Persons;Pharmaceutical Preparations;pilot test;Prevalence;primary care clinic;primary care setting;Primary Health Care;primary outcome;Privatization;programs;Reach, Effectiveness, Adoption, Implementation, and Maintenance;secondary outcome;Self Management;Site;Social support;System;telehealth;Training;Translational Research;treatment as usual;trend;Uninsured;United States;Universities;virtual;virtual group;virtual model;virtual platform;Visit;Work

PROJECT_TITLE: VIDA: Virtual Diabetes Group Visits Across Health Systems


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Rehabilitation;Substance Misuse

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE The U.S. Deaf community – a group of more than 500,000 Americans who communicate using American Sign Language (ASL) – experiences nearly triple the rate of lifetime problem drinking compared to the general population. Yet, there are no therapy approaches that have been developed and formally tested to treat problem drinking or alcohol use disorder among Deaf clients. The proposed K23 study will begin to address this gap by supporting the development and preliminary validation of Deaf Motivational Enhancement Therapy (Deaf- MET), a Deaf-accessible pre-treatment for alcohol use disorder.

PI_NAMEs: WILKINS, ALEXANDER MONROE (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Address;Adult;Aftercare;Alcohol abuse;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol related problem;alcohol use disorder;American;American Sign Language;Awareness;Caring;Client;Clinical;Collaborations;Combined Modality Therapy;commune;Communication;Communities;community engaged intervention;community engaged research;community engagement process;deaf;design;Development;disability;disabled;drinking behavior;Employment;evidence base;Evidence based treatment;Exclusion;Exhibits;experience;falls;Focus Groups;fourth grade;General Population;Goals;Health;Hearing;hearing impairment;help-seeking behavior;high risk;Impairment;Individual;Intervention;intervention refinement;Lead;Learning;Linguistics;Logic;low health literacy;Manuals;Mentored Patient-Oriented Research Career Development Award;method development;Modeling;Motivation;motivational enhancement therapy;Parents;Participant;Persons;physical conditioning;pilot test;prototype;Radio;Reading;Recording of previous events;Recovery;recruit;Reduce health disparities;relapse prevention;research and development;Research Personnel;Resources;response;Rhode Island;satisfaction;Series;Services;social norm;Socialization;Testing;Text;therapy design;therapy development;tool;Translations;Treatment Efficacy;Universities;Validation;Visual;Writing

PROJECT_TITLE: Designing Deaf-MET: A Deaf-Accessible Pre-Treatment for Alcohol Use Disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Physical Rehabilitation;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

PI_NAMEs: HUISINGH-SCHEETZ, MEGAN J (contact)

PROJECT_TERMS: Activities of Daily Living;Adopted;Adoption;Adult;African American;African American population;age acceleration;age group;Aging;American;Behavior;behavior change;Behavioral;Cardiovascular system;Caregiver support;Caring;Cessation of life;Chicago;Chronic;Chronic Disease;Cognition;Communities;comorbidity;Complex;design;disability;disability risk;Disease Management;Effectiveness;efficacy testing;efficacy trial;Elderly;empowerment;Equity;ethnic minority;Evidence based intervention;Exercise;exercise intervention;experience;Face;Feasibility Studies;Feedback;Focus Groups;frailty;Frequencies;functional gain;functional independence;Goals;Habits;Hand Strength;Health;Health Services;high risk;Hispanic Populations;Home;Hospitals;Hour;Household;human old age (65+);Illinois;improved;improved mobility;Individual;informal care;informal caregiver;innovation;Internet;Intervention;intervention delivery;Intervention Trial;life span;literacy;Long-Term Care;Low income;Lower Extremity;Medicare;Metabolic;Methodology;Mobility disability;multiple chronic conditions;Musculoskeletal;Musculoskeletal Physiology;Not Hispanic or Latino;novel;older adult;Paper;Persons;Physical activity;Physical Function;Physical Performance;Physiological;Physiology;preservation;prevent;primary outcome;programs;Psychological reinforcement;Quality of Care;Race;racial minority;Randomized;recruit;Reduce health disparities;rehabilitation service;remote intervention;Research;Resources;Risk Reduction;sedentary;Services;skills;social;social engagement;Social Functioning;Social Reinforcement;social relationships;Speed;Syndrome;System;Technology;Testing;Theory of Change;Time;tool;Training;treatment as usual;Treatment Efficacy;Upper Extremity;user-friendly;Voice;Vulnerable Populations

PROJECT_TITLE: Voice-Activated Technology to Improve Mobility & Reduce Health Disparities: EngAGEing African American Older Adult-Care Partner Dyads


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Breast Cancer;Cancer;Genetics;Immunotherapy;Neurosciences;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Narrative-Relevance  This revised R01 application tackles one of the most challenging problems in the cancer field: brain metastases (BM). The major goal of this research is to determine how the dynamic interactions of MHC-II on BM tumor cells and Lag3 on microglia, the unique innate immune cells in the brain, control BM, and to develop novel therapeutic strategies using clinically-applicable epigenetic drugs to enhance MHC-II expression and immune response to treat BM. Our research findings can be smoothly translated to clinical trials, leading to new and better BM treatments to enhance the quality of life and prolong survival of patients suffering from BMs.

PI_NAMEs: YU, DIHUA  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: adaptive immune response;Affect;Arteries;Binding;Biological;Biology;bone;Brain;brain control;Brain Neoplasms;brain parenchyma;C57BL/6 Mouse;cancer cell;Cancer Center;Cancer Patient;cancer type;CD3 Antigens;Cell model;Cell surface;Cells;Cephalic;checkpoint therapy;Clinic;Clinical;clinical application;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Data Set;Development;Disease;Early Intervention;empowerment;Environment;EO771;epigenetic drug;Epigenetic Process;epigenetic regulation;epigenetic silencing;Extravasation;EZH2 gene;Fatty acid glycerol esters;FDA approved;functional decline;Functional impairment;Gene Expression Profiling;gene network;Genes;Genetic Screening;Goals;Growth;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;Image;Immune;Immune response;Immunity;Immunotherapy;improved;in vivo;Incidence;Infiltration;inhibitor;Innate Immune Response;Intracarotid;Knock-out;Knockout Mice;Lesion;Lesion by Stage;Liver;Lung;Magnetic Resonance Imaging;Major Histocompatibility Complex;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;mammary;Mediating;Medical;Melanoma;Metastasis Induction;Metastatic malignant neoplasm to brain;Microglia;Modification;Mus;Myelogenous;Neoplasm Metastasis;neoplastic;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Patient-derived xenograft models of breast cancer;Patients;Phase;Physical environment;Pre-Clinical Model;Preclinical Testing;Primary Neoplasm;Protein Array;Quality of life;Recurrent disease;Refractory;Research;Resected;response;SCID Mice;single-cell RNA sequencing;Stains;Survival Rate;synergism;T-Lymphocyte;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Tissues;transcriptome sequencing;Translating;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Vorinostat;Wild Type Mouse

PROJECT_TITLE: Exploring the Function of MHC-II/Lag3 Axis in Brain Metastasis to Develop Novel Therapeutic Strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

ORG_CITY: UNIVERSITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI

ORG_STATE: MS

PHR: Project Narrative. Spirulina is a top selling botanical for improving immune health. This proposal is directed towards generating sufficient data to optimally design future human intervention studies to evaluate the utility of Spirulina-derived oral supplements in promoting resilience against viral infections such as influenza. The use of a Spirulina-derived oral supplement may provide an important complementary approach to currently available antiviral therapies that is inexpensive, safe and readily available to the public.

PI_NAMEs: KHAN, IKHLAS AHMAD (contact);PUGH, NIRMAL D

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Address;Advisory Committees;Animal Model;Anti-viral Therapy;Asthma;Biological Assay;Biological Markers;Botanical dietary supplements;Botanicals;burden of illness;career development;Cessation of life;Chemicals;Clinical Immunology;Clinical Research;clinical trial protocol;Clinical Trials;Collaborations;Communication;Data;design;Doctor of Philosophy;Dose;Drug Delivery Systems;economic impact;efficacy clinical trial;efficacy study;Ensure;Evaluation;feeding;Formulation;Future;graduate student;Hospitalization;Host resistance;Human;human disease;human model;Human Subject Research;Hypersensitivity;Immune;immune health;Immune response;Immunology;improved;In Vitro;infection risk;Influenza;influenza infection;influenza virus vaccine;Intervention Studies;Knowledge;Learning;Legal patent;Lipoproteins;Liquid substance;Maintenance;Medical center;Medicine;meetings;member;mid-career faculty;Mississippi;Modeling;Modernization;Molecular;multidisciplinary;Mus;Natural Products;oral supplementation;Outcome Measure;Pathogenicity;Patients;Persons;Pharmacodynamics;Pharmacy (field);Population;Postdoctoral Fellow;Powder dose form;prevent;professor;programs;promote resilience;Property;Prophylactic treatment;Recovery;Regimen;Reproducibility;Research;Research Personnel;Research Project Grants;resilience;Resource Allocation;Scientist;seasonal influenza;socioeconomics;Spirulina preparation;Standardization;Structure;Supplementation;synergism;Therapeutic;Time;training opportunity;Universities;Viral;Viral Respiratory Tract Infection;Virus Diseases;web site;Work

PROJECT_TITLE: Spirulina oral supplement for enhancing host resilience to virus infection


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Influenza;Natural Products;Nutrition;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: MARSHALL, GAILEN D. (contact)

PROJECT_TERMS: age related;Allergic;anti-influenza;Antibodies;Antibody Response;Antibody titer measurement;Antigens;Autoimmune;Back;Biological Markers;Botanical dietary supplements;Botanicals;CD8B1 gene;Cell Count;Cell Line;Cells;Cessation of life;Chronic;Clinical Research;Clinical Trials;Cyanobacterium;cytokine;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;cytotoxicity;Data;design;Development;dietary supplements;Doctor of Philosophy;dosage;Drug Kinetics;Elderly;Elements;Evaluation;Exhibits;flu;Food;Future;Health;HIV;Hospitalization;Host resistance;Human;human model;Immune;Immune response;Immunity;Immunologics;Immunomodulators;improved;Individual;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;influenza infection;influenza virus vaccine;influenzavirus;Interleukin-15;Interleukin-2;Knockout Mice;Knowledge;Life;Life Style;Lipoproteins;Lymphocyte Count;Mediating;Medical;Medical center;Mississippi;Modeling;Modernization;mouse model;Mus;Natural Killer Cells;Oral;Oral Administration;Oral Ingestion;oral supplementation;pandemic influenza;Participant;Pathogenicity;Pathway interactions;Patients;Persons;Placebos;Population;Predisposition;professor;programs;promote resilience;prophylactic;Prophylactic treatment;protective effect;Provider;Public Health;Recovery;Reporting;Research;Research Project Grants;resilience;response;Risk;seasonal influenza;side effect;Signal Pathway;Societies;Spirulina preparation;Supplementation;Syndrome;System;Technology;Therapeutic;Therapeutic immunosuppression;Time;timeline;TLR2 gene;Transplantation;Universities;Vaccines;Viral;Viral Respiratory Tract Infection;Virus Diseases

PROJECT_TITLE: Examining the Effects of Immulina to Increase Immune Resilience against Influenza Virus Infections


NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Infectious Diseases;Natural Products;Nutrition

PI_NAMEs: CHITTIBOYINA, AMAR G. (contact)

PROJECT_TERMS: Achievement;Address;Agonist;Algae;Anti-Inflammatory Agents;Biological Assay;biological standardization;Botanical dietary supplements;Botanicals;Cells;Cessation of life;Chemicals;Chemistry;Clinical Trials;Collaborations;Complement;design;Doctor of Philosophy;efficacy study;Ensure;Evaluation;Exhibits;experience;Future;Hospitalization;Human;Immune;immune function;Immune response;Immune Targeting;improved;in vitro Assay;in vitro Bioassay;Influenza;Innate Immune Response;Intervention Studies;Lipoproteins;macromolecule;Macrophage Activation;Materials Testing;Measures;Medicine;member;Methodology;Methods;Mississippi;Natural Products;Natural Products Chemistry;novel;oral supplementation;Outcome;Patients;Production;promote resilience;Property;quality assurance;Reproducibility;Research;Research Personnel;Research Project Grants;resilience;safety testing;Sampling;Spirulina preparation;Standardization;System;TLR2 gene;United States;Universities;Variant;Viral;Viral Respiratory Tract Infection;Virus Diseases;Work

PROJECT_TITLE: Botanical Core


NIH_SPENDING_CATS: Complementary and Integrative Health

PI_NAMEs: TAN, CHALET  (contact)

PROJECT_TITLE: Unravelling Immune Enhancement by Immulina


PI_NAMEs: KHAN, IKHLAS AHMAD (contact)

PROJECT_TERMS: Advisory Committees;Algae;authority;Biological;Botanical dietary supplements;Botanicals;career;career development;Collaborations;Communication;Consultations;data sharing;Dedications;design;Development;Ensure;Environment;Evaluation;experience;Fellowship;flexibility;Future;Goals;graduate student;Human;Human Resources;Immune;International;Intervention Studies;Journals;Legal patent;meetings;Mississippi;Monitor;Natural Products;oral supplementation;Outcome;Peer Review;Policies;Positioning Attribute;Postdoctoral Fellow;Principal Investigator;Productivity;programs;Property;Publications;Regulation;Research;Research Personnel;Research Priority;Research Project Grants;resilience;Resources;Spirulina preparation;Structure;symposium;synergism;Training;training opportunity;United States National Institutes of Health;Universities;Update;Viral;Virus Diseases;web site

PROJECT_TITLE: Admin Core


ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative PHACS 2020 is a Program Project P01 grant, consisting of the following four support Cores: Scientific Administrative Core (SAC), Data Resources Core (DRC), Health Education and Community Core (HECC), and the Epidemiological and Statistical Methods Core (ESC) to provide scientific, site and cohort infrastructure, data management and analysis, health education and community input, as well as epidemiological and statistical support to four Research Projects: 1) Surveillance Monitoring for ART Toxicities (SMARTT); 2) The Adolescent Master Protocol (AMP) Up Series (the AMP Up Series); 3) Natural History of Cervical Intraepithelial Neoplasia (CIN) and Human Papillomavirus (HPV) in HPV Vaccinated Youth with Perinatal HIV (PHIV) (HPV); and 4; the TERBO BRAIN Study: Trajectories of Emotional Regulation and Behavior Outcomes and related Brain Regions And Intrinsic Networks (TERBO BRAIN). This multidisciplinary, interactive and synergistic P01 will address the most critical scientific questions for children, youth and young adults living with or exposed to perinatal HIV.

PI_NAMEs: CHADWICK, ELLEN GOULD;HERNANDEZ-DIAZ, SONIA ;JAO, JENNIFER ;WILLIAMS, PAIGE L (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: 13 year old;Address;Adolescent;Adolescent and Young Adult;Adult;adverse birth outcomes;Age;Aging;Anti-Retroviral Agents;Behavior;behavioral outcome;Brain;Brain region;cardiometabolism;Caring;Centers for Disease Control and Prevention (U.S.);Cervical Intraepithelial Neoplasia;Child;Child Health;clinical research site;Cognitive;cohort;Cohort Studies;Communities;Data Analyses;data management;data resource;design;Development;Disease;Disease remission;Effectiveness;emotion regulation;emotional behavior;Epidemiologic Methods;Epidemiology;experience;Exposure to;Grant;Growth;Guidelines;Health;Health education;HIV;HIV Infections;HPV-High Risk;Human papilloma virus infection;Human Papillomavirus;in utero;Individual;Infant;Infant Health;Infection;Infrastructure;Life Cycle Stages;Long-Term Effects;Monitor;multidisciplinary;Natural History;neurodevelopment;Neurologic;Oral health;oral HPV;Outcome;Pediatric HIV/AIDS Cohort Study;Perinatal;perinatal HIV;Persons;Pharmaceutical Preparations;Population;postnatal;Pregnant Women;Prevalence;Prevention;Program Research Project Grants;programs;Prospective, cohort study;Protocols documentation;reproductive;Research Project Grants;Risk;Risk Factors;Safety;Series;Site;social factors;Statistical Methods;structural determinants;success;Testing;Toxic effect;transition to adulthood;transmission process;treatment response;Vaccinated;young adult;young man;young woman;Youth

PROJECT_TITLE: Pediatric HIV/AIDS Cohort Study (PHACS) 2020

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AARR-J(40)]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Prevention;Sleep Research;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Narrative During the previous period of support we identified brain regions and clinical symptoms affected by childhood maltreatment that prospectively increased risk for substance use and created the Maltreatment and Abuse Chronology of Exposure scale and novel AI procedures to identify type and timing of maltreatment that were the most important predictors of brain changes and risk for substance use. One aim of this continuing program of research is to provide the first rigorous test of our hypothesis that maltreated and non-maltreated individuals with substance used disorders have distinctly different neurobiological signatures, and that maltreatment and attention-deficit hyperactivity disorder represent two distinctly different pathways to substance use, with far reaching implications for prevention, treatment and discovery. The second aim is to determine the degree to which inflammation and sleep stage disruption mediate the association between sensitive period exposure, brain changes and clinical symptoms in order to identify mediators that can be targeted to prevent the emergence of substance use in high-risk maltreated individuals and to potentially augment the effects of treatment in substance users.

PI_NAMEs: TEICHER, MARTIN H (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Accounting;adverse childhood events;Affect;Age of Onset;Amygdaloid structure;Anger;associated symptom;Attention deficit hyperactivity disorder;Award;Basal Ganglia;Behavior;biological adaptation to stress;Blood;Blood flow;Brain;brain morphology;Brain region;Brain-Derived Neurotrophic Factor;Cerebellar vermis structure;Characteristics;Child Abuse and Neglect;Chronic;Chronology;Clinical;Cocaine;Data;design;Development;Disease;disorder subtype;Drug Addiction;drug of abuse;Drug usage;early life stress;emerging adult;Epigenetic Process;executive function;experience;Exposure to;Functional disorder;gender difference;Glucocorticoids;Goals;Heterogeneity;high risk;Hippocampus;Hostility;Household;Impulsivity;Individual;Inflammation;inflammatory marker;Insula of Reil;Intervention;Knowledge;longitudinal, prospective study;maltreatment;Measures;Mediating;Mediator;Mental Depression;Methamphetamine;Molecular;Morphology;morphometry;network architecture;Neurobiology;novel;Opioid;Participant;Pathway interactions;Pharmaceutical Preparations;Phase;Polysomnography;Population Attributable Risks;portability;Predisposition;Prefrontal Cortex;prevent;Prevention;Prevention strategy;Procedures;programs;prospective;Psychopathology;Recording of previous events;Recovery;Regulation;Relapse;Research;research study;resilience;response;Risk;Risk Factors;risk prediction;Severities;Sleep disturbances;Sleep Stages;Stress;Structure;substance use;Substance Use Disorder;substance user;symptomatology;Symptoms;Testing;therapeutic target;tool;treatment effect;treatment strategy;Variant;Youth

PROJECT_TITLE: Early Stress and the Neurobiology of Susceptibility and Resilience to Substance Use Disorders

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

ORG_CITY: BOSTON

PI_NAMEs: SEAGE, GEORGE R (contact)

PROJECT_TERMS: Accountability;Advisory Committees;Agreement;Award;Bylaw;career;career development;Clinical Research;Collaborations;Communication;Communities;community advisory board;Conflict of Interest;Contracts;data resource;design;Ensure;Epidemiologic Methods;financial conflict of interest;Financial Disclosures;Fostering;Foundations;frontier;Funding;General Population;Group Meetings;Health education;HIV;Leadership;Mediation;meetings;member;Mentors;Monitor;outreach;Pediatric HIV/AIDS Cohort Study;Performance;Policies;Principal Investigator;Program Research Project Grants;programs;Public Health Schools;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Role;Science;Statistical Methods;Structure;Talents;Technology;timeline;working group

PROJECT_TITLE: Scientific Administrative Core (SAC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AARR-J]


PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Biometry;Clinical Data;Clinical Investigator;Clinical Management;clinical research site;Collaborations;Communication;Communities;community advisory board;Data;data access;Data Analyses;data integration;data management;data resource;Data Storage and Retrieval;Databases;Epidemiologic Methods;Epidemiology;Foundations;frontier;Health education;Human Resources;Institutional Review Boards;Laboratories;Leadership;meetings;member;Monitor;operation;Pediatric HIV/AIDS Cohort Study;Performance;Principal Investigator;Process;Program Research Project Grants;programs;Public Health Schools;Research;Research Project Grants;Resource Sharing;Resources;Sampling;Sampling Studies;Science;Services;Statistical Methods;Technology;Time

PROJECT_TITLE: PHACS Data Resources Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Maternal Health;Mental Health;Neurosciences;Patient Safety;Pediatric;Pediatric - AIDS;Pregnancy;Prevention;Substance Misuse;Women's Health Research

PHR: Project Narrative The Surveillance Monitoring for ART Toxicities (SMARTT) Study of the Pediatric HIV/AIDS Cohort Study (PHACS) network has been enrolling and following infants and children who are HIV-exposed but uninfected (CHEU) born to women with HIV, with over 4000 CHEU enrolled over the past 14 years. The primary goal of the PHACS SMARTT study is to evaluate the short-term and long-term safety of maternal antiretroviral treatment (ART) during pregnancy on health outcomes in CHEU across a wide range of domains, including growth, neurodevelopment, cardiometabolic, hearing, language, oral, and maternal health. This proposal describes our strategy for continued enrollment and follow-up of CHEU to inform ART guidelines and optimize the efficacy and safety of ART use in pregnancy.

PI_NAMEs: WILLIAMS, PAIGE L (contact)

PROJECT_TERMS: 17 year old;5 year old;Adult;adverse birth outcomes;Adverse effects;Adverse event;adverse outcome;Age;Anti-Retroviral Agents;antiretroviral therapy;Birth;cardiometabolism;case-based;Child;Child Health;Clinical;clinical research site;Clinical stratification;clinically relevant;cohort;comparison group;Conceptions;congenital anomaly;cost effective;Databases;design;Enrollment;Epidemiologic Methods;Evaluation;experience;follow-up;Funding;Future;Goals;Growth;Guidelines;Health;Hearing;high risk;HIV;hospitalization rates;improved;in utero;Infant;Infant Health;Infection;innovation;Insulin Resistance;interest;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Investigation;Laboratories;Language;large datasets;Lipids;Longterm Follow-up;Maternal Health;maternal safety;meetings;Metabolic;Monitor;mortality;Mothers;neurodevelopment;Oral health;Outcome;Pediatric HIV/AIDS Cohort Study;Perinatal;perinatal HIV;Periodicals;Pharmaceutical Preparations;postnatal;Pregnancy;pregnant;Pregnant Women;Premature Birth;prenatal;Prevention;Productivity;Public Health;Random Allocation;Recommendation;Regimen;Reporting;Research;Research Design;Resolution;Risk;Safety;safety outcomes;Statistical Methods;success;Suggestion;surveillance study;synergism;System;Tenofovir;Time;Toxic effect;transmission process;treatment guidelines;treatment optimization;Treatment-related toxicity;Woman;Zidovudine


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on gaining a better understanding of the immunology of infection of Clostridioides difficile, a common GI bacterial pathogen that can cause extensive inflammation and tissue damage. Our goal is to harness early innate immunity to improve the patient’s immune response against the bacteria, to resolve infection and/or prevent re-infection. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to preventing and curing human diseases.

PI_NAMEs: ZENEWICZ, LAUREN A (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Affect;Amino Acids;Arginine;Autoimmunity;Bacteria;Bacterial Infections;Biology;Cell Physiology;Cells;Clostridioides difficile vaccine;Clostridium difficile;combat;cytokine;Data;Development;Disease;DL-alpha-Difluoromethylornithine;effective therapy;Elderly;enzyme biosynthesis;Enzymes;Epithelium;evidence base;Failure;Family;FDA approved;gastrointestinal;gastrointestinal infection;Gastrointestinal tract structure;Gene Expression Regulation;Genetic Transcription;Glycolysis;Goals;Health;human disease;Immune;Immune response;Immune system;Immunity;Immunocompromised Host;Immunology;improved;improved outcome;in vivo;Incidence;Infection;Inflammation;Innate Immune Response;interest;interleukin-22;interleukin-23;Intoxication;Ion Transport;Lymphocyte;Lymphocyte Activation;Lymphocyte Biology;Malignant Neoplasms;Mediating;Metabolic Pathway;Metabolism;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;Mucosal Immune Responses;Mucosal Immunity;Mucous Membrane;Mus;Natural Immunity;novel;Ornithine Decarboxylase;Outcome;Oxidative Phosphorylation;pathogen;pathogenic bacteria;Pathway interactions;Patients;Pharmaceutical Preparations;phase III trial;Polyamines;prevent;Primary Infection;Production;Proliferating;Protein Analysis;Protein Biosynthesis;Public Health;Publishing;Putrescine;Recombinant Interleukins;Recurrence;Recurrent disease;Relapse;Research;response;Role;secondary infection;Severities;Severity of illness;Spermidine;Spermine;targeted treatment;Testing;Tissues;Toxin;transcriptome sequencing;Translations;United States National Institutes of Health;Virulence Factors;Work

PROJECT_TITLE: Understanding and leveraging immunometabolism to combat Clostridioides difficile infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The United States is currently experiencing an opioid crisis and nearly 20 million Americans have a substance abuse disorder. Changes to AMPA receptors in the brain or receptor plasticity is a hallmark of addiction linked to the development of additive behavior and withdrawal, but the molecular mechanisms that regulate AMPA receptors during drug addiction are unknown. I will investigate the molecular mechanisms that control AMPA receptor plasticity and identify potential therapeutic targets to support development of more effective treatments for drug addiction.

PI_NAMEs: CERTAIN, NOËLE DOREEN (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: addiction;Addictive Behavior;Affect;American;AMPA Receptors;Animal Model;autism spectrum disorder;Behavior;Biogenesis;Brain;Brain Diseases;cholinergic;Complex;Data;Development;Developmental Delay Disorders;dimer;Disease;Drug Addiction;Drug Exposure;effective therapy;Electrophysiology (science);experience;Functional disorder;gel electrophoresis;Glutamate Receptor;Goals;Hippocampus;Homologous Gene;Human;Image;in vivo;innovation;insight;Intellectual functioning disability;Interruption;Ion Channel Gating;Knowledge;Laboratories;Learning;Link;Measures;Mediating;Memory;Missense Mutation;Modeling;Molecular;Neurobiology;Neurodevelopmental Disorder;Neurons;Neurosciences;novel;novel strategies;opioid epidemic;Patients;Pharmaceutical Preparations;Phase;Positioning Attribute;Postdoctoral Fellow;Process;Psychological reinforcement;receptor;receptor expression;Regulation;Research;Research Project Grants;Rewards;Rodent Model;Role;Signal Transduction;skills;Slice;Substance abuse problem;Surface;Synapses;synaptic function;Synaptic plasticity;Synaptic Receptors;Synaptic Transmission;System;targeted treatment;Techniques;Testing;Therapeutic;therapeutic development;therapeutic target;trafficking;Training;Transmembrane Domain;United States;Variant;Withdrawal;Work

PROJECT_TITLE: Impact of Trio Insufficiency on Cholinergic Development and Function


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Substance Misuse

PHR: Project Narrative The PHACS (Pediatric HIV/AIDS Cohort Study) Adolescent Master Protocol (AMP) Up Series (AMP Up Series) of studies – AMP Up and AMP Up Lite – are following a cohort of young adults with perinatal HIV (YAPHIV) and a comparison group of young adults with perinatal HIV exposure who are uninfected, a substantial proportion of whom have longitudinal data since early childhood on HIV status, antiretroviral medications, and clinical outcomes. Their primary goal is to evaluate the impact of HIV disease and its treatment on health and behavior outcomes across a wide range of domains, including cardiopulmonary, metabolic, mental health, neurological, neurocognitive, oral, reproductive, substance use and sexual behaviors, emotional, social and academic functioning, and health care utilization and access. This proposal describes our strategy for continued follow-up of these young adults to inform research and interventions for YAPHIV worldwide.

PI_NAMEs: TASSIOPOULOS, KATHERINE K. (contact)

PROJECT_TERMS: 15 year old;18 year old;Address;Adherence;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Age;Aging;Alcohol consumption;Anti-Retroviral Agents;antiretroviral therapy;Behavior;behavioral health;Body Composition;bone;Bone Density;Brain;Cardiac;Cardiopulmonary;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Caring;Centers for Disease Control and Prevention (U.S.);Cervical;Child;Clinic;Clinic Visits;Clinical;clinical care;cohort;Cohort Studies;comparison group;Data;Data Collection;design;Disease;Disease remission;early childhood;Emotional;emotional functioning;Enrollment;Ensure;Epigenetic Process;Family dynamics;flexibility;follow-up;Generations;Genetic;Goals;Growth;Gynecologic;Health;Health behavior and outcomes;health care service utilization;health management;Healthcare;Hearing;high risk;HIV;HIV Infections;Human Papillomavirus;Immunologic Factors;Individual;Infant;Inflammatory;Influentials;innovation;Intervention;Kidney;Language;Lesion;Long-Term Effects;Longterm Follow-up;Lung;Medical;Mental Health;Metabolic;Nervous System Physiology;Neurocognitive;neurodevelopment;Neurologic;Nutritional;Oral;Oral health;Organ;Outcome;Participant;Pediatric HIV/AIDS Cohort Study;pediatric human immunodeficiency virus;Perinatal;perinatal HIV;Persons;Pharmaceutical Preparations;Physical assessment;physical conditioning;Postpartum Period;Productivity;Protocols documentation;Psyche structure;pubertal timing;Publications;recreational drug use;reproductive;reproductive outcome;Research;Research Design;Role;scale up;Self Management;Series;Sex Behavior;Sexual Maturation;Sexually Transmitted Diseases;social;social factors;Social Functioning;Social support;sociodemographics;structural determinants;Structure;substance use;Tobacco use;Toxic effect;transition to adulthood;treatment adherence;treatment response;vaccine efficacy;Viral;Viremia;Visit;Vocation;Woman;young adult

PROJECT_TITLE: The Adolescent Master Protocol (AMP) Up Series Project


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Sexually Transmitted Infections;Substance Misuse;Vaccine Related;Women's Health Research

PHR: Project Narrative It is unclear if young adults perinatally HIV infected (YAPHIV) are protected against human papilloma virus (HPV) associated cancers by the HPV vaccine. We have the opportunity to examine the natural history of HPV in HPV-vaccinated YAPHIV. The results of this study would inform clinical and policy guidelines for HPV vaccination strategies and cervical cancer screening in resourced and resource poor settings.

PI_NAMEs: MOSCICKI, ANNA-BARBARA  (contact)

PROJECT_TERMS: Adolescent;Adult;Age;Antibody titer measurement;biobank;Biological Markers;Biopsy;Cervical;Cervical Cancer Screening;Child;Clinical;Colposcopy;Cytology;Data;Development;Diagnosis;Disease;Event;Future;General Population;Genotype;Guidelines;high risk population;HIV;HIV Infections;HPV positive;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;improved;Incidence;Infant;Infection;Inflammatory;Intravaginal Administration;Lesion;malignant mouth neoplasm;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Squamous Cell Neoplasm;Marketing;men;metabolomics;microbiome;Morbidity - disease rate;Natural History;Negative Staining;Oral;oral HPV;Pediatric HIV/AIDS Cohort Study;Perinatal;perinatal HIV;Perinatal transmission;Persons;Policies;Polygamy;Prevalence;prevent;prospective;Prospective, cohort study;Protease Inhibitor;Protocols documentation;Research;Resource-limited setting;Resources;Risk Factors;Sampling;screening;Self Administration;Sex Behavior;sexual debut;Specificity;Stains;Swab;Testing;Triage;unvaccinated;Vaccinated;vaccination strategy;vaccine access;vaccine failure;Vaccines;Vagina;Viral Load result;Woman;young adult;young man;young woman;Youth

PROJECT_TITLE: Natural History of CIN and HPV in HPV Vaccinated Youth with PHIV