NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The goal of this research program is to develop computational methods that enhance the role of metabolomics in systems biology approaches for biomarker discovery. Specifically, statistical, network-based, and machine learning methods will be developed for ranking putative metabolite IDs and selection of metabolite biomarker candidates. The performance of the proposed methods for metabolite identification and biomarker selection will be evaluated through experimental methods including: (1) comparing the fragmentation patterns of unknown analytes against those from reference compounds; and (2) targeted quantitative analysis of selected metabolites. 2

PI_NAMEs: RESSOM, HABTOM W (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Biological;Biological databases;Biological Markers;biomarker discovery;biomarker selection;biomarker validation;candidate marker;candidate selection;computerized tools;Computing Methodologies;computing resources;Control Groups;Coupled;Data;data integration;Development;Disease;Evaluation;Future;Genomics;glycoproteomics;Goals;high throughput analysis;improved;Individual;innovation;Libraries;Liquid Chromatography;Machine Learning;machine learning method;Mass Fragmentography;Mass Spectrum Analysis;metabolomics;Methods;Multiomic Data;multiple omics;network models;Network-based;Outcome;Pattern;Performance;Play;programs;Proteomics;Research;Resources;Role;Sampling;small molecule;statistical and machine learning;System;Systems Biology;transcriptomics;Validation;validation studies

PROJECT_TITLE: Systems Metabolomics for Biomarker Discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: NARRATIVE Our Ultrascale Machine Learning Initiative, or “ULTRA” - is a coordinated national initiative to develop transformative AI approaches for high throughput analysis of next generation sequencing (NGS) and related AD biomarker and cognitive data. Biomarker data related to AD are being collected at “ultra-scale” and are likely to unlock numerous opportunities for AD treatment, yet the rapid collection of such data far exceed our current capacity to analyze it. Our collective effort in this proposal will sieve extensive genomic, biomarker, and cognitive data to extract and prioritize the features that are essential to address fundamental barriers to AD prevention and drug discovery.

PI_NAMEs: DAVATZIKOS, CHRISTOS ;HUANG, HENG ;SAYKIN, ANDREW J;SHEN, LI ;THOMPSON, PAUL M (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Academia;Acceleration;Address;Affect;Algorithms;Alzheimer disease detection;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;analytical method;analytical tool;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence method;Big Data Methods;biobank;Biological;Biological Markers;Cerebrovascular Disorders;Clinical;clinical subtypes;Clinical Trials;cloud based;Cognition;Cognitive;cognitive performance;cognitive system;cognitive testing;Collection;Communities;Data;Data Analyses;Data Collection;data curation;data dissemination;data fusion;data harmonization;data integration;data modalities;Data Set;Data Sources;Databases;Dedications;deep learning;demographics;design;Dimensions;Disease;Disease Progression;disorder subtype;drug development;drug discovery;Drug Industry;drug repurposing;Drug Targeting;Early Diagnosis;Educational workshop;empowerment;endophenotype;experience;Frequencies;Genes;Genetic;genetic analysis;Genetic Diseases;genetic signature;genetic variant;Genome;genome sequencing;genome wide association study;genomic data;genomic predictors;Genomics;Genotype;Goals;hazard;high throughput analysis;Image;imaging biomarker;imaging genetics;Impaired cognition;improved;indexing;Informatics;informatics tool;interest;International;large scale data;Leadership;Link;Machine Learning;machine learning method;Mathematics;Methods;Molecular;Multimodal Imaging;Nerve Degeneration;Network-based;neurobiological mechanism;Neurobiology;neuroimaging;neuroimaging marker;neuropathology;new therapeutic target;next generation sequencing;novel;Participant;Pattern;personalized genomics;personalized medicine;Pharmaceutical Preparations;Phenotype;phenotypic data;Positioning Attribute;pre-clinical;predictive marker;predictive modeling;Predictive Value;prevent;Research;Research Personnel;Research Priority;response;Risk;risk prediction;Role;Sampling;Scoring Method;Source;specific biomarkers;Speed;Statistical Methods;Structure;Subgroup;Systems Analysis;tau Proteins;Testing;tool;Training;translational impact;United States National Institutes of Health;Variant;whole genome;Work

PROJECT_TITLE: Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease Biobanks


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Heart Disease;Hematology;Stroke

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting approximately 35 million people worldwide, and is associated with the risk of blood clots forming in the left atrial appendage and traveling to the brain resulting in strokes. The risk of strokes in patients with AF can be reduced with anticoagulation medications, but these increase the risk of bleeding and current methods of deciding who should get these are not personalized and contain no information about patients' cardiac anatomy. This proposal uses novel simulation techniques and analyses of contrast-enhanced cardiac CT images to develop a pilot patient-specific score to better risk stratify the risk of thrombosis in patients with AF.

PI_NAMEs: DEL ALAMO, JUAN CARLOS ;KAHN, ANDREW  (contact);MCVEIGH, ELLIOT R

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Affect;Age;Algorithms;analysis pipeline;Anatomy;Anticoagulation;Arrhythmia;Atrial Fibrillation;auricular appendage;Blood;Blood coagulation;Blood flow;blood rheology;Blood Viscosity;Brain;Cardiac;Clinical;Clinical Research;clinical translation;Coagulation Process;cohort;comorbidity;comparison group;Complex;computer framework;Computer Models;cone-beam computed tomography;Consumption;contrast enhanced;contrast enhanced computed tomography;Contrast Media;cost;Data;Data Set;Demographic Factors;disability;embolic stroke;Engineering;Equilibrium;Goals;Heart;Heart Atrium;heart imaging;hemodynamics;Hemorrhage;Hypertension;Image;Image Analysis;image processing;improved;improved outcome;Injections;innovation;insight;Kinetics;Left;Liquid substance;Maps;Measures;Methods;Modeling;mortality;Motion;neglect;novel;Outcome;Patient risk;patient stratification;Patients;Persons;Pharmaceutical Preparations;Physics;Physiological;Pilot Projects;Population;predictive modeling;prevent;Protocols documentation;Radiation Dose Unit;Recording of previous events;Resolution;Rheology;Risk;Risk Reduction;risk stratification;sex;simulation;spatiotemporal;statistics;Stratification;Stroke;stroke patient;stroke risk;Techniques;thrombogenesis;Thrombosis;Thrombus;Time;tool;translational goal;Travel;Uncertainty;United States;Variant;Work;X-Ray Computed Tomography

PROJECT_TITLE: Patient-specific thrombosis risk in atrial fibrillation by 4D CT imaging of atrial kinetics combined with computational fluid dynamics


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE:  GABAergic interneurons play key roles in the function and maintenance of the neocortex. This proposal will determine how interneurons that express somatostatin (SST-INs) across layers contribute to the circuits underlying spontaneous and sensory-evoked neuronal activity in mouse visual cortex. We expect our findings to provide important insights into the cellular underpinnings of visual processing and behavioral state modulation by the brain.

PI_NAMEs: FANG, CALVIN  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Anatomy;Behavior monitoring;Behavioral;Brain;calcium indicator;career;Categories;Cells;Data;Dendrites;Development;Electrophysiology (science);Exhibits;experimental study;flexibility;Future;Genetic;Goals;Heterogeneity;hippocampal pyramidal neuron;Image;in vivo;information processing;insight;Interneuron function;Interneurons;Knowledge;Learning;Maintenance;mature animal;Measures;Methodology;Mus;Neocortex;neocortical;Neurons;neuroregulation;Neurosciences;Noise;operation;optogenetics;Output;Pattern;Peptides;Physicians;Play;Population;presynaptic;Property;protein expression;rabies viral tracing;recruit;redshift;Regulation;Research;response;Role;Sensory;Signal Transduction;skills;Somatostatin;Synapses;System;Techniques;Testing;Tissues;Training Programs;two photon microscopy;two-photon;Viral;Visual;Visual Cortex;visual processing;visual receptive field;visual stimulus;visual tracking;Work

PROJECT_TITLE: Functional diversity of somatostatin interneurons in visual cortical circuits


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: NARRATIVE Emerging evidence suggests that mothers of children with autism spectrum disorder are at increased risk for accelerated cognitive aging. Given the high numbers of children (1 in 54) and adults (1 in 45) with ASD coupled with the percentage of mothers who continue to care for the adolescent and adult children through mid-life into old age (up to 65%), this research has key public health relevance, as dementia-related disease in these mothers will affect a large percentage of the population and their families. This project will examine cognitive aging in mothers of children with ASD using a comprehensive neuropsychological battery, as well as the effect of risk factors for dementia-related diseases that are elevated in these mothers, including stress, depression, loneliness, reduced social support, and poor sleep quality.

PI_NAMEs: FRIEDMAN, LAURA ANNE (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Acceleration;Adolescent;Adult;Adult Children;Affect;Age;age acceleration;age effect;age group;age related;Age-associated memory impairment;Aging;Alzheimer's Disease;autism spectrum disorder;autistic children;Caregivers;Caring;Child;Child Rearing;Cognition;Cognitive;Cognitive aging;Cognitive deficits;cognitive performance;comparison group;Coupled;Data;Dementia;dementia risk;Development;developmental disease;Disabled Children;Disease;Disease susceptibility;Environment;Environmental Risk Factor;Evaluation of Risk Factors;experience;Family;Fragile X Syndrome;General Population;Genes;Genetic;Grant;Hereditary Disease;Heritability;High Prevalence;high school;Home;human old age (65+);Impaired cognition;Infrastructure;insight;Language;late life;Literature;Loneliness;Measurement;Measures;Memory;Mental Depression;Mentors;Mentorship;middle age;mild cognitive impairment;Modeling;Mothers;Neurodevelopmental Disorder;Neuropsychological Tests;Neuropsychology;Outcome;Parents;Participant;Pattern;Performance;performance tests;Phenotype;poor sleep;Population;Predisposition;psychosocial;Psychosocial Factor;Public Health;public health relevance;Questionnaires;Reporting;Research;Resources;Risk;Risk Factors;risk prediction;Role;Short-Term Memory;sleep quality;Social support;Source;South Carolina;Stress;Supervision;tau Proteins;Tauopathies;theories;Training;training project;Universities;verbal;Work

PROJECT_TITLE: Neuropsychological Profiles and Risk for Dementia-Related Disease in Mothers of Children with Autism Spectrum Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(21)]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BIRMINGHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Sepsis remains a significant health concern for children, with a hospital mortality rate of 25% globally. A key driver of organ injury and death in children with sepsis is vascular disease, although the discrete mechanisms driving this pathology remain elusive. This proposal will uncover mechanisms that promote vascular dysfunction to facilitate the development of successful therapies for children suffering with sepsis.

PI_NAMEs: RICHTER, ROBERT P (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Adenosine Monophosphate;Angiopoietin-2;antagonist;Attenuated;autocrine;Automobile Driving;Benchmarking;Binding;Biological Markers;Biology;Blood Vessels;career;career development;Career Mobility;Cell secretion;Cell surface;Cells;Cessation of life;Child;Clinical;Clinical Research;clinical translation;Data;Death Rate;Dedications;Development;Development Plans;electric impedance;Endothelial Cells;endothelial dysfunction;Endothelium;exosome;Flow Cytometry;Fostering;Functional disorder;Funding;gain of function;Glycocalyx;Goals;Health;Heparitin Sulfate;Hospital Mortality;Hour;Human;Impairment;In Vitro;in vivo;Injury;Institution;International;Knowledge;lung microvascular endothelial cells;Measures;Mediating;Mentors;Mentorship;Modeling;Modern Medicine;monolayer;Morbidity - disease rate;mortality;mRNA Expression;Mus;nanoparticle;neutralizing antibody;novel;novel therapeutics;Observational Study;Organ;organ injury;Outcome;paracrine;Pathology;Pathway interactions;pediatric sepsis;Permeability;Physicians;Plasma;Process;Productivity;programs;promoter;Property;prospective;protein expression;Protein Kinase;Research;Research Training;Resources;Role;Scientist;Sepsis;septic;shear stress;Signal Pathway;Signal Transduction;small molecule;STK11 gene;Surface;Techniques;Testing;Therapeutic;therapeutic target;TIE-2 Receptor;Training;Training Programs;Translational Research;translational scientist;United States National Institutes of Health;Vascular Diseases;vascular endothelial dysfunction;vascular injury;Vascular Permeabilities;Work

PROJECT_TITLE: Mechanisms driving endothelial angiopoietin-2 expression and vascular dysfunction during pediatric sepsis

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health

PHR: In 2020 in Ukraine OPWH reported low (34%) levels of HIV status disclosure to support networks, with those who did not disclose their HIV status 20% were less likely to adhere to ART in the last month, and twice less likely to adhere to therapy for non-HIV comorbidities, than those who disclosed. Using ADAPT-ITT, evidence-based adaptation strategy, we will adapt an evidence-based intervention to create self-administered Decision Aid PORADA (Pursuing Optimal Results over Aging via Decision Aid, “porada” means “advice” in Ukrainian), and pilot test it to assist OPWH make informed decisions about HIV disclosure aligned with their unique needs. Two trained Social Workers will distribute PORADA to 80 OPWH who have at least one person they consider important to them to whom they have not disclosed their HIV status and these participants will be followed up for 12 months and compared to 40 OOC OPWH receiving treatment as usual.

PI_NAMEs: ROZANOVA, JULIA  (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Aging;anxiety symptoms;Appointment;Caring;Central Asia;Child health care;Clinical;Communities;comorbidity;Conflict (Psychology);Consultations;Data;Decision Aid;Decision Making;depressive symptoms;Development;Diagnosis;disability-adjusted life years;Disclosure;Distal;Eastern Europe;effectiveness/implementation trial;Elderly;Elements;empowerment;Ensure;evidence base;Evidence based intervention;experience;Family;follow-up;Fostering;frailty;Friends;Funding;Goals;Health Benefit;health related quality of life;Healthcare;HIV;HIV diagnosis;Hotlines;implementation measures;improved;improved outcome;Incidence;innovation;insight;Intervention;Knowledge;Link;low and middle-income countries;Maternal and Child Health;Measures;Mental Health;Modeling;mortality;multidisciplinary;older adult;Outcome;Participant;Partner Notification;patient-level barriers;Patients;peer;Persons;Pharmaceutical Preparations;pilot test;Population;Primary Care;primary outcome;Public Health;Randomized;Reaction;Recommendation;Reporting;Research Assistant;Resources;Risk;Self Administration;Self Perception;social stigma;Social support;Social Workers;Standardization;Stigmatization;success;Support Groups;support network;systemic barrier;Testing;Time;tool;Training;treatment as usual;Trust;two-arm study;Ukraine;Viral;Withdrawal;Work;working group

PROJECT_TITLE: Adapting a disclosure decision-aid to improve HIV outcomes for older adults in Ukraine

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: HD

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Services;Immunization;Infectious Diseases;Mental Health;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Vaccine Related

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The goal of this study is to generate new knowledge on trajectories of child/adolescent mental health and primary healthcare utilization including immunization, in the aftermath of the COVID- 19 pandemic. The findings from this study will help understand the impact of the pandemic on health outcomes, vulnerability to future shocks, and sources of heterogeneity in these relationships.

PI_NAMEs: MASELKO, JOANNA ;MOHANAN, MANOJ  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: 2019-nCoV;Adolescent;adolescent mental health;Castes;Child;Child Health;Child Mental Health;Consumption;COVID-19;COVID-19 impact;COVID-19 pandemic;Data;Data Collection;Data Set;Documentation;economic outcome;Economics;evidence base;experience;Exposure to;falls;Family;Future;Gender;Goals;Grant;Health;health care service utilization;health data;Health Surveys;Health trends;Healthcare;Heterogeneity;Household;Immunization;improved;Income;India;Individual;Inequality;innovation;Intervention;Job loss;Knowledge;large datasets;life span;Longitudinal Studies;member;Mental Health;Occupations;Outcome;pandemic disease;pandemic impact;Periodicity;Personal Satisfaction;physical conditioning;Policies;Population;population health;Primary Health Care;programs;Public Health;public-private partnership;Publishing;Research;Research Personnel;Resource-limited setting;Risk Factors;Sampling;SARS-CoV-2 exposure;school closure;severe COVID-19;Shock;social;Social Environment;Source;statistics;stem;stressor;Surveys;Testing

PROJECT_TITLE: Longitudinal study of health outcomes and mitigating factors in the aftermath of the COVID pandemic

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Chronic Obstructive Pulmonary Disease;Clinical Research;Lung;Palliative Care;Patient Safety

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Over 16 million older Americans living with an incurable lung disease called chronic obstructive pulmonary disease report high levels of distress and poor quality of life. These patients and their informal caregivers make decisions based on the patients’ values and goals, relying on their expectations for the patient’s future health. This longitudinal project will provide critical information about the origins and impact of patients’ and caregivers’ expectations for patients’ future physical and emotional symptoms in order to improve shared decision making and quality of life for these patients and caregivers.

PI_NAMEs: HART, JOANNA LEE (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Advance Care Planning;Ambulatory Care Facilities;American;Baptist Church;Behavioral;Benefits and Risks;Black race;burden of illness;care delivery;Caregiver well-being;Caregivers;Caring;Case Study;Cause of Death;Characteristics;Chronic Obstructive Pulmonary Disease;Clinic Visits;Clinical;clinical care;clinical decision-making;Cognitive;cohort;Cohort Studies;Communication;Communities;coping;Decision Making;Decision Theory;Disparity;Distress;Emotional;emotional symptom;Emotions;expectation;experience;Family Caregiver;Foundations;Funding;Future;Geography;Goals;Health;health management;health related quality of life;Health system;Healthcare;improved;Individual;individual patient;informal caregiver;innovation;insight;Intervention;Investigation;Knowledge;Link;Lung;Lung Diseases;Measurement;Measures;Mediating;Methodology;Methods;Modeling;Mood Disorders;National Heart, Lung, and Blood Institute;novel;older adult;optimism;Outcome;Palliative Care;Participant;patient expectation;patient population;patient subsets;patient-clinician communication;Patients;Pennsylvania;Personal Satisfaction;physical symptom;Predisposition;preference;prevent;Prospective, cohort study;provider communication;psychologic;Quality of life;Race;recruit;Reporting;Research Infrastructure;Risk;Role;Rural;shared decision making;sociodemographics;socioeconomics;success;Symptom Burden;Symptoms;Testing;therapy development;Thinking;Time;treatment risk;United States National Institutes of Health;Universities;Update;Work

PROJECT_TITLE: Improving shared decision making in lung disease

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Precision Medicine;Women's Health Research

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE We will develop a new mechanistic understanding of cancer cell cycle dysregulation and resistance pathways using an experimentally validated mathematical model applied to patient tumor cells. These analyses will provide a guide to personalized treatment combinations and dosing for more durable control of cancer cell proliferation.

PI_NAMEs: NATH, ARITRO  (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Acceleration;Automobile Driving;Biological Models;Biopsy;Breast Cancer Cell;Breast Cancer Patient;Bypass;cancer cell;Cancer Control;Cancer Patient;CDK4 gene;Cell Cycle;Cell Cycle Checkpoint;Cell Cycle Progression;Cell Cycle Regulation;Cell division;Cell Line;Cell Lineage;Cell Proliferation;cell type;Cells;Cessation of life;Chemosensitization;Clinical;Clinical Trials;Collection;Combined Modality Therapy;Couples;Cyclin-Dependent Kinase Inhibitor;Data;design;Dose;Drug Combinations;Drug Modelings;drug testing;Drug usage;Effectiveness;Endocrine;Equilibrium;ERBB2 gene;ErbB4 gene;Estrogen receptor positive;Estrogens;Evolution;experimental study;Feedback;Gene Expression;Gene Expression Profile;Hand;hormone therapy;improved outcome;In Vitro;in vitro Model;in vivo;inhibitor;kinase inhibitor;Letrozole;Malignant Breast Neoplasm;MAP Kinase Gene;Maps;mathematical model;Measurement;Measures;Mediating;Mitogen-Activated Protein Kinase Kinases;Modeling;neoplastic cell;Outcome Study;Pathway interactions;patient response;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacotherapy;Phosphotransferases;Population;Preoperative Endocrine Therapy;prevent;Proliferating;promoter;reconstruction;refractory cancer;Repression;Resistance;resistance mechanism;response;Role;Sampling;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;spheroids;System;targeted treatment;Testing;Therapeutic;therapy resistant;Time;tool;transcriptomics;treatment strategy;tumor;tumor heterogeneity;Tumor stage;Up-Regulation

PROJECT_TITLE: Mechanism of estrogen independent proliferation in ER+ breast cancer cells


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

ORG_STATE: NY

PHR: Despite their high risk for HIV acquisition, key populations under the age of 18--including youth who sell sex and adolescent men who have sex with men--are often excluded from research that can potentially improve their health in sub-Saharan Africa. Increased understanding of ethical challenges and solutions in HIV research with underage key populations in African settings can reduce barriers to the responsible conduct of such research. This study will involve a systematic review of where and how underage key populations have been included in HIV research in Africa, surveillance of African countries' policies on parental consent for minors' participation in research, and surveys and focus groups of research ethics committee members in Africa and HIV researchers who have conducted studies with key populations in Africa that included or excluded minors.

PI_NAMEs: GROSSO, ASHLEY LYNN (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: adolescent men who have sex with men;Africa;Africa South of the Sahara;African;Age;Attitude;Botswana;Characteristics;Committee Members;Country;Development;Ethics;Ethics Committees;Exclusion;experience;female sex worker;Focus Groups;Funding;Government;Health;high risk;HIV;improved;Individual;Institution;Institutional Review Boards;Intervention;Knowledge;Legal;member;men who have sex with men;Minor;multilevel analysis;Outcome;Parental Consent;Participant;Policies;Population;Readiness;Recommendation;Reporting;Research;Research Ethics Committees;Research Personnel;Review Literature;Risk;Self Efficacy;sex;Sex Behavior;Stigmatization;Surveys;systematic review;Testing;Therapeutic;Training;Uganda;Universities;waiver;willingness;Youth

PROJECT_TITLE: Ethics of HIV-related research involving underage key populations in sub-Saharan Africa


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunotherapy

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Project Narrative This study will yield a comprehensive structural characterization of the human butyrophilin 3 complex, a key protein complex in the immune response to infectious diseases and cancer. Because ligand binding to butyrophilin 3 enables attacks of human immune cells against foreign cells, it is being pursued as a promising new drug target. The structural data from this project will be used to enable structure-based drug design, which could lead to new therapeutic agents for treating infections and cancer or to genetic probes to increase understanding of the human immune response.

PI_NAMEs: VINOGRADOVA, OLGA ;WIEMER, ANDREW J (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Address;Affect;alpha-beta T-Cell Receptor;analytical ultracentrifugation;antigen detection;Antigen-Presenting Cells;Antigens;Binding;Binding Proteins;Binding Sites;Biological;Biological Assay;Biological Models;Biology;Biophysics;butyrophilin;cancer cell;Cell Line;Cell Physiology;Cell surface;Cell Surface Receptors;Cells;Chemicals;clinical development;Clinical Trials;Co-Immunoprecipitations;Communicable Diseases;Complex;Conflict (Psychology);Confusion;CRISPR/Cas technology;crosslink;Cryoelectron Microscopy;cytokine;Cytolysis;Cytoplasm;Cytoprotection;cytotoxic;Cytotoxic T-Lymphocytes;Data;dimer;Disease;disorder prevention;Distant;Drug Design;Epitopes;Exposure to;Extracellular Domain;Extracellular Protein;Family member;Fluorescence Resonance Energy Transfer;Genetic;Goals;Human;Immune;immune activation;immune checkpoint;Immune response;immunoregulation;Immunotherapy;In Vitro;Infection;insight;Interferon Type I;K562 Cells;Length;Libraries;Ligand Binding;Ligands;Literature;Malignant Neoplasms;Mediating;Membrane;Membrane Glycoproteins;Modeling;Molecular;Molecular Conformation;Molecular Target;mutant;Mutate;nanodisk;new therapeutic target;novel;novel therapeutics;Organizational Change;Peptides;Phosphorus;Point Mutation;preservation;Prodrugs;Production;protein complex;Protein Isoforms;protein protein interaction;Proteins;receptor;Reporting;Research;response;Roentgen Rays;Role;Shapes;small molecule;Structural Models;Structure;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Therapeutic Agents;therapy development;tool;Visualization;Western Blotting;γδ T cells

PROJECT_TITLE: Role of immune modulating butyrophilins in gamma delta T cell activation

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Pathological aggregation of the protein tau is a hallmark of Alzheimer’s disease (AD) and other tauopathies. This proposal aims to dissect the mechanism by how the presynaptic protein Bassoon works as a scaffold to stabilize and facilitate the trans-synaptic spreading and neurotoxicity of a tau pathological-seed. This work may provide important information that will increase our understanding in the mechanisms and the nature of the tau species involved in the phenomenon of propagation and neurodegeneration.

PI_NAMEs: LASAGNA-REEVES, CRISTIAN  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Acceleration;Affect;Affinity;Age;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Autophagocytosis;Autopsy;base;bassoon protein;Behavioral;Biochemical;Bioinformatics;Brain;Clinical;Complex;cytomatrix;Data Set;Disease;Down-Regulation;Electrophysiology (science);genome wide association study;Goals;Heterogeneity;Histologic;Human;human model;Image;in vivo;Individual;Knowledge acquisition;Link;loss of function;Maintenance;Mass Spectrum Analysis;Medicine;Microfluidics;Modeling;Molecular;Molecular Conformation;Molecular Weight;monomer;mouse model;mutant;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;neuropathology;neurotoxicity;non-demented;novel;Pathogenesis;Pathologic;Pathology;Pathway Analysis;Patients;Physiological;Play;presynaptic;Process;Progressive Supranuclear Palsy;Property;protein aggregation;Proteins;Proteomics;proteostasis;Reporting;Research;Risk Factors;Role;Sampling;scaffold;Scaffolding Protein;Series;Structure;superresolution microscopy;Synapses;Synaptic Vesicles;Syndrome;System;tau aggregation;tau interaction;tau Proteins;Tauopathies;Testing;Tissues;transcriptome sequencing;Work

PROJECT_TITLE: Tau-seed protein interactome and its role in neurodegenerative tauopathies

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Infectious Diseases;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: Project narrative Antiretroviral therapy (ART) adherence among nursing home (NH) residents with HIV is less than optimal where 21% of people with HIV were not dispensed ART from their NH contrasts with 87.5% adherence that is reported among older people with HIV in the community. Viral suppression, stability of chronic conditions, and mortality are vulnerable to changes in ART adherence. We propose examining facilitators and barriers to changes in ART adherence during the community-to-long-stay-NH-transition period using mixed methods with administrative claims data, thematic analysis of interviews with people with HIV that have had a long- NH-stay, and triangulation.

PI_NAMEs: OLIVIERI-MUI, BRIANNE  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Adherence;Affect;Age;aged;Aging;Anti-Retroviral Agents;antiretroviral therapy;beneficiary;Caring;Cessation of life;Characteristics;Chronic;Clinical;Communities;Computer software;contextual factors;Data;Data Set;Databases;Dementia;design;disability;Drug usage;Elderly;Enrollment;Ensure;Equation;experience;Face;frailty;Future;Geriatrics;Goals;Guidelines;Health;health care service utilization;Health Policy;Health Services Research;HIV;HIV Seronegativity;Home Nursing Care;Homelessness;housing instability;improved;Individual;Intervention;Interview;K-Series Research Career Programs;Knowledge;Life Cycle Stages;Linear Regressions;Link;Literature;Logistic Regressions;Medicaid;Medicare;Medicare claim;Medicare/Medicaid;Mentors;Mentorship;Methods;Modeling;mortality;New York;New York City;nursing home length of stay;Nursing Homes;Older Population;Outcome;Patients;Pattern;Perception;Persons;Policies;Population;prevent;Quality of Care;Recording of previous events;recruit;Reporting;Research;Research Methodology;Research Personnel;Resources;Risk;Sampling;sex variable;skills;social determinants;social disparities;social health determinants;socioeconomics;Special needs plan;Structure;Techniques;Testing;theories;therapy adherence;Time;Training;transmission process;Universities;Viral;Work

PROJECT_TITLE: Understanding antiretroviral adherence changes from the community to the nursing home

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Gene Therapy;Genetics;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative In response to the need for effective treatments for severe genetic disorders, we are exploring gene and cell therapies in a skin-blistering disease—recessive dystrophic epidermolysis bullosa (RDEB)—caused by errors in a single gene. Our laboratories combine areas of expertise specific to this project: extensive research into RDEB, production of unique mouse models, a long history of cellular therapy, and state-of-the art gene editing technologies in operation. We hope to identify which of the current gene-editing technologies are safest and most effective to use in this disorder, to identify the optimal cells for correction and skin repair, and then to test the corrected optimal cells in a mouse model we have developed (that has RDEB and will accept human cells) to see if we can improve skin healing with this therapy.

PI_NAMEs: TOLAR, JAKUB  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Address;Affect;Anemia;Area;Autoimmunity;Autologous;base;base editing;Binding;Biodistribution;Biological;biological systems;Bulla;Burn injury;Cell Lineage;Cell Therapy;cell type;Cells;Chemicals;clinical application;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;COL7A1;Collagen Gene;Collagen Type VII;combinatorial;Complex;Contracture;Corneal Abrasion;Data;Deaminase;Deoxyribonucleases;Disease;DNA;DNA Damage;effective therapy;Engraftment;Epidermolysis Bullosa Dystrophica;Esophageal Stenosis;Fibroblasts;Fibrosis;functional restoration;gene correction;gene editing technology;gene therapy;Gene Transfer;Genes;Genetic Diseases;Genome;Genotoxic Stress;genotoxicity;Goals;healing;Human;Immune response;improved;in vivo evaluation;Individual;induced pluripotent stem cell;Induction of Apoptosis;Inflammation;Inflammatory Response;insight;Joints;keratinocyte;Laboratories;Laboratory Study;Lead;life span;loss of function mutation;Loss of Heterozygosity;Malignant - descriptor;Malnutrition;Measures;Mediating;member;Membrane;Membrane Proteins;Mesenchymal Stem Cells;mesenchymal stromal cell;Modeling;Molecular;molecular pathology;mouse model;Mucous Membrane;Mus;Mutation;Nature;next generation;novel;nuclease;Nucleotides;operation;Patients;permissiveness;Persons;Phenotype;phosphodiester;polymerization;Polymers;pre-clinical;Pre-Clinical Model;Production;Proteins;prototype;Reagent;Recording of previous events;Research;response;Rest;restoration;Risk;Side;Site;Skin;skin healing;Skin injury;Skin repair;Source;Squamous cell carcinoma;stem cells;Stress;Stromal Cells;Testing;Therapeutic;Therapeutic Intervention;tool;Toxic effect;Tropism;Ulcer;vector;Work;wound;wound healing;Xenograft procedure

PROJECT_TITLE: Skin-targeted Cell Therapy for Recessive Dystrophic Epidermolysis Bullosa

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE - OVERALL An urgent need exists to develop better strategies for the prevention of cancer in high-risk subjects, and in particular, in those who have inherited a predisposition for the disease. In close collaboration with the NCI and other Centers, Fox Chase Cancer Center (FCCC) proposes to utilize multidisciplinary expertise, novel cutting-edge technology, and biospecimens and data from mutation carriers in the FCCC Risk Assessment Program to identify agents that can effectively disrupt the earliest steps in tumor formation. Establishment of FCCC as a member of a highly collaborative Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) is anticipated to accelerate the development of efficacious preventive agents and have a significant impact on reducing the burden of cancer among those at highest risk of disease.

PI_NAMEs: CLAPPER, MARGIE L. (contact)

PROGRAM_OFFICER_NAME: GUNASEKHARAN, VIGNESH KUMAR

PROJECT_TERMS: Acceleration;Address;Adult;African ancestry;Antibodies;Area;Atlases;Award;Barrett Esophagus;Bioinformatics;Biological Assay;biological specimen archives;Biometry;Cancer Biology;Cancer Burden;Cancer Center;cancer diagnosis;cancer prevention;cancer risk;Cell Line;Chronic;clinical risk;clinically relevant;cohort;Collaborations;Colonic Polyps;Communication;Computational Biology;Contractor;Data;data management;data sharing;Development;Disease;disorder risk;Division of Cancer Prevention;Dose;Drug Design;drug development;drug discovery;Early Detection Research Network;Early identification;Early treatment;efficacious intervention;efficacy study;Engineering;Epithelial Cells;Event;experience;Family;Fibroblasts;Fostering;Fox Chase Cancer Center;Future;Genetic Risk;genetic variant;Germ-Line Mutation;Goals;Growth;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;Heritability;high risk;High-Risk Cancer;improved;In Vitro;in vivo;in vivo evaluation;Individual;individualized prevention;Informatics;Inherited;innovation;insight;Intercept;Intervention;Knowledge;Laboratory Research;Lead;Leadership;Lesion;Li-Fraumeni Syndrome;lifetime risk;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical Genetics;member;Molecular;Molecular Abnormality;molecular modeling;Molecular Profiling;Molecular Target;mouse model;multidisciplinary;mutant;Mutation;mutation carrier;netrin-G1;neutralizing antibody;novel;Operative Surgical Procedures;Oral Leukoplakia;Organ;overexpression;Pancreas;Pancreatic Intraepithelial Neoplasia;Pathway interactions;Phenotype;Population;pre-clinical;precision cancer prevention;Predisposition;premalignant;prevent;Prevention strategy;Preventive;preventive intervention;Productivity;programs;prophylactic;Proteins;public database;rational design;Regimen;Research;Research Personnel;Resource Sharing;Resources;Risk Assessment;Risk Reduction;screening;targeted agent;Technology;therapy development;time use;Toxic effect;TP53 gene;Training;tumor;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Validation

PROJECT_TITLE: Cancer Prevention-Interception Targeted Agent Discovery Program at Fox Chase Cancer Center


NIH_SPENDING_CATS: Cancer;Precision Medicine;Prevention

PROJECT_TERMS: Attention;Biological;cancer prevention;Collaborations;Communication;Communities;conflict resolution;Consultations;Data;Educational workshop;efficacy testing;Ensure;Evaluation;Fox Chase Cancer Center;Goals;Hereditary Neoplastic Syndromes;in vivo;Informatics;Infrastructure;Interdisciplinary Study;Laboratory Research;Leadership;Malignant Neoplasms;meetings;member;Molecular Target;Monitor;multidisciplinary;pre-clinical;precision cancer prevention;Prevention;Productivity;programs;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Resource Sharing;Resources;screening;skills;success;targeted agent;Technical Expertise;Validation

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: ROSS, ERIC ANDREW (contact)

PROJECT_TERMS: Achievement;anti-cancer research;archive data;Atlases;Bioinformatics;Biological Markers;Biometry;Cancer Biology;Cancer Control Research;cancer prevention;cancer risk;candidate validation;Cell Line;Chemoprevention;Clinical;Clinical Investigator;Clinical Trials;Collaborations;Computer software;Computers;Data;Data Analyses;data archive;data management;data repository;data resource;data sharing;Data Storage and Retrieval;Database Management Systems;Databases;design;Development;diverse data;Environment;Epidemiology;experience;Experimental Designs;flexibility;Fostering;Fox Chase Cancer Center;Future;Genetic;Goals;high risk;Informatics;Information Systems;Infrastructure;innovation;Knowledge;Laboratories;Laboratory Scientists;Malignant Neoplasms;Manuscripts;member;Mission;Molecular;Molecular Analysis;Nature;novel;Pathway interactions;Phase;Play;pre-clinical;precision cancer prevention;preclinical study;premalignant;Prevention Research;Procedures;Program Research Project Grants;programs;Proteomics;public database;Randomized;Research;research and development;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Resources;Retrieval;Risk Assessment;Role;Sample Size;Science;Secure;Services;skills;Structure;System;targeted agent;Technology;tool;tumor;Writing

PROJECT_TITLE: Informatics Core


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MATHER

ORG_NAME: VA NORTHERN CALIFORNIA HEALTH CARE SYS

PHR: One in four Veterans is affected by diabetes and will develop a diabetic foot ulcer. Diabetic ulcers are very challenging to manage and are the most common cause of leg amputation. Many advanced treatments are expensive and difficult to use in the clinic or at home. Those newer therapies have shown little success in healing diabetic foot wounds. Our laboratory and animal work has suggested that a safe medication, currently used as an eye drop for treatment of glaucoma, can heal these ulcers. We are proposing to test this drop (timolol) directly on the surface of the foot ulcer to see if it can improve healing faster than the current standard of care. To do this, we propose a “randomized controlled trial” with two groups of patients with diabetic foot ulcers: one will receive standard of care with timolol while the other will receive standard of care with a gel (hydrogel, as placebo medicine).

PI_NAMEs: DAHLE, SARA  (contact);ISSEROFF, ROSLYN RIVKAH

PROJECT_TERMS: Adrenergic beta-Antagonists;Adverse event;Affect;Amputation;Analysis of Covariance;Analysis of Variance;angiogenesis;Animal Model;Animals;Basic Science;Blinded;Body System;California;Caring;Cells;Characteristics;Chronic;chronic wound;Clinic;Clinical;Clinical Data;Clinical Management;Clinical Research;clinical translation;Clinical Trials Cooperative Group;Colon Carcinoma;comorbidity Index;Control Groups;cost;Cutaneous;Data;Debridement;Dermatologic;Devices;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;diabetic patient;diabetic ulcer;Disease;Double-Blind Method;Drainage procedure;Drops;early phase clinical trial;Electronics;Eligibility Determination;Enrollment;Eyedrops;follow-up;Foot Ulcer;Functional disorder;Gel;Glaucoma;healing;Health Surveys;Healthcare;Healthcare Systems;Home;Human;Hydrogels;Impaired healing;improved;In Vitro;Individual;Informed Consent;Isopropanol;keratinocyte;Knowledge;Laboratories;Laboratory Research;Leg;lifetime risk;limb amputation;Logistic Regressions;Lower Extremity;Measurement;Measures;Medical Care Costs;Medicine;Methods;migration;Morbidity - disease rate;mortality;necrotic tissue;novel strategies;novel therapeutics;Outcome Measure;pandemic disease;Patients;Persons;Pharmaceutical Preparations;Phase;Placebos;Population;pressure;primary endpoint;Productivity;psychologic;Quality of life;Randomized;Randomized, Controlled Trials;re-epithelialization;recidivism;recruit;Recurrence;Reporting;Research;Research Design;Research Personnel;response;Risk;Safety;Sample Size;screening;secondary endpoint;secondary outcome;Serum;Side;Skin;social;Sodium Chloride;standard of care;Sterile coverings;Strawberry nevus;study population;success;Surface;System;Testing;Therapeutic;Therapeutic Research;Time;Timolol;Topical application;Translating;translational study;Trauma;treatment arm;treatment group;Ulcer;United States;United States Department of Veterans Affairs;Veterans;Visit;Wages;Work;wound;wound care;wound closure;wound healing

PROJECT_TITLE: Beta Adrenergic Antagonist For The Healing of Chronic Diabetic Foot Ulcers

STUDY_SECTION: SURG

STUDY_SECTION_NAME: Surgery[SURG]


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PI_NAMEs: KARANICOLAS, JOHN  (contact)

PROJECT_TERMS: Address;Adverse effects;analog;Animals;Binding;Biochemical;Biophysics;Cancer cell line;cancer prevention;Cell Line;Cellular Assay;Characteristics;Chemicals;Defect;design;Disease;DNA;DNA Binding;Drug Design;drug testing;early onset;efficacy testing;Event;Family;Female;Fox Chase Cancer Center;gain of function;Germ Lines;Germ-Line Mutation;Goals;Hereditary Disease;Heterozygote;high risk population;Histologic;improved;In Vitro;in vivo;in vivo Model;Individual;Intercept;Lesion;Li-Fraumeni Syndrome;loss of function;male;Malignant Neoplasms;Maps;Mediating;Membrane Proteins;Missense Mutation;Modeling;Molecular Conformation;mouse model;Mus;mutant;Mutate;Mutation;novel;novel therapeutics;Null Lymphocytes;Oncogenic;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;premalignant;Prevention;Primary Prevention;programs;Property;Proteins;Safety;safety testing;screening;Series;Somatic Mutation;Squamous cell carcinoma;Structure;Structure-Activity Relationship;targeted agent;Testing;Thermodynamics;Time;Tissues;Toxic effect;TP53 gene;transcription factor;Transfection;tumor;Validation;Work

PROJECT_TITLE: Refolding Mutant p53: A Strategy for Cancer Prevention in Li-Fraumeni Syndrome


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Immunization;Immunotherapy;Pancreatic Cancer;Prevention;Rare Diseases

PI_NAMEs: CUKIERMAN, EDNA  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;Affinity;Antibody Therapy;Benign;Binding;Biological Assay;Biological Availability;Biology;Body Weight;BRCA2 gene;BRCA2 Mutation;cancer predisposition;cancer prevention;cancer risk;cell growth;Cell model;cell type;cellular engineering;chemokine;Clinical;clinical candidate;Coculture Techniques;Collagen;Data;Data Analyses;Desmoplastic;Development;Diabetes Mellitus;Diagnosis;Ductal Epithelial Cell;Early Diagnosis;effectiveness evaluation;efficacy testing;Engineering;Environment;Epithelial Cells;Epitopes;Evolution;experimental study;Exposure to;Extracellular Matrix;Familial pancreatic cancer;Family history of;Fibroblasts;Fox Chase Cancer Center;Genes;Genetic Predisposition to Disease;genetic variant;Germ-Line Mutation;Goals;Growth;high risk;Human;Immunologic Surveillance;improved;In Vitro;in vivo;Individual;Inherited;inhibiting antibody;Intercept;Interruption;Intervention;Lead;lead candidate;Lesion;lifetime risk;liver function;loss of function;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;molecular marker;Molecular Target;Monoclonal Antibodies;mouse model;Mus;Mutagens;mutation carrier;netrin-G1;neutralizing antibody;neutralizing monoclonal antibodies;novel;novel strategies;Nutrient;Nutritional Support;Organ;PALB2 gene;Pancreas;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;Pancreatic duct;Pancreatic Intraepithelial Neoplasia;Pancreatitis;Patients;Penetration;Phenocopy;Phenotype;Population;premalignant;Premalignant Cell;Preventive;Primary Neoplasm;programs;Property;Proprotein Convertase 2;Risk Factors;Safety;screening;Series;Signal Transduction;Smoker;Stress;Syndrome;System;targeted agent;Testing;Tissues;Toxic effect;tumor;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;tumor-immune system interactions;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Neutralizing Stromal NetrinG1 to Intercept Pancreatic Cancer


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases

ORG_CITY: ORANGE

ORG_NAME: CHAPMAN UNIVERSITY

PHR: Project Narrative Infection with Kaposi Sarcoma-associated Herpesvirus (KSHV), a herpesvirus primarily transmitted via saliva, is conclusively linked to several cancers in the context of immune dysfunction, and despite many years of research, fundamental questions remain about how KSHV is transmitted from person-to-person. In this proposal, we will determine the origin, role and significance of mature antibody-secreting B cells (plasma cells) as targets for early KSHV infection. The mechanisms defined in this study will provide novel insights into KSHV transmission and identify new targets for limiting the ability of the virus to invade the human immune system.

PI_NAMEs: TOTONCHY, JENNIFER E (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Anatomy;Antibodies;Automobile Driving;B-Lymphocyte Subsets;B-Lymphocytes;Biological Models;Biology;Cell Count;Cell Lineage;cell type;Cells;Cellular biology;cytokine;design;Disease;Endothelial Cells;Epithelial Cells;Etiology;Event;Exposure to;Genetic Transcription;Goals;Herpesviridae;Herpesviridae Infections;HIV;Human;Human Herpesvirus 8;Immune;Immune system;Immune System Diseases;Immunologics;Individual;Infection;Infectious Agent;Inflammatory;insight;interleukin-21;Invaded;Kaposi Sarcoma;latent infection;Libraries;Link;Lymphatic Endothelial Cells;Lymphocyte;Lymphoid Tissue;Lymphoproliferative Disorders;Lytic;Lytic Phase;Maintenance;Malignant Neoplasms;Mesenchymal;Modeling;Morbidity - disease rate;mortality;Mucous Membrane;Multicentric Angiofollicular Lymphoid Hyperplasia;mutant;novel;Oncogenic;Oral;Oral cavity;oral immunology;Persons;plasma cell differentiation;Plasma Cells;Play;primary effusion lymphoma;programs;Recombinant Proteins;Research;Role;Saliva;Signal Transduction;Site;Specimen;Syndrome;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Tissues;Tonsil;tool;transmission process;Transplant Recipients;Tropism;tumor;Viral;viral transmission;Virus;Virus Diseases;Work

PROJECT_TITLE: Defining the role of plasma cells in the establishment of KSHV infection in human tonsil


ADMINISTERING_IC: AA

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse

ORG_CITY: PISCATAWAY

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Fetal alcohol exposure can lead to neurotoxicity associated with structural and functional damage to the brain. It is crucial to elucidate mechanisms of neurotoxicity in order to develop effective therapeutic strategies. Our proposed study will determine a novel mechanism of ethanol-induced β-EP neuronal toxicity involving microglia-derived exosomes and chemokines, complements and miRNAs.

PI_NAMEs: SARKAR, DIPAK KUMAR (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Adult;Adverse effects;alcohol exposure;Alcohol-Induced Neurotoxicity;Alcohols;Animal Model;Animals;Anxiety;anxiety-like behavior;Apoptosis;Apoptotic;Astrocytes;Behavior;Behavioral;beta-Endorphin;Biogenesis;biological adaptation to stress;Blood;Body Fluids;Brain;cell behavior;Cell Death;Cell Maturation;Cell membrane;Cell secretion;cell type;Cells;Central Nervous System;Cerebrospinal Fluid;Cessation of life;chemokine;Child;Chronic;Clinical;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;Communication;Corticosterone;Corticotropin;cytokine;Defect;dietary control;Emotional Disturbance;Endothelial Cells;Enzyme-Linked Immunosorbent Assay;Ethanol;exosome;experience;extracellular vesicles;fetal;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Genes;genomic data;Genomics;Growth;Homeostasis;Hormonal;Human;Human Milk;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Immune;immune function;In Situ;In Vitro;in vivo;Individual;Induced Neurons;Infant formula;Inflammatory;Integral Membrane Protein;knock-down;Laboratory mice;Laboratory Rat;Learning Disabilities;Lipid Bilayers;Lipids;Measurement;Measures;Mental disorders;Microglia;MicroRNAs;microvesicles;Modeling;monocyte;Mood Disorders;Names;nerve stem cell;Neurobiology;Neuroglia;Neurologic;neuron apoptosis;neuron loss;Neurons;neurotoxicity;neurotransmission;Newborn Infant;novel;novel therapeutic intervention;Oligodendroglia;Oligonucleotides;Oxidative Stress;particle;Pathway interactions;Patients;Peptides;Physiological;Play;POMC gene;Population;postnatal;postnatal period;pre-clinical;Predisposition;Pregnancy;prenatal;Prevalence;prevent;Pro-Opiomelanocortin;Problem behavior;Production;Property;Proteins;Proteomics;Rattus;Regulation;Reporting;Research;response;Reverse Transcriptase Polymerase Chain Reaction;RNA;Role;Sampling;Series;Signal Pathway;Signal Transduction;socioeconomics;stem;stem cell growth;Stress;Techniques;Testing;therapeutically effective;Third Pregnancy Trimester;Tissues;Transplantation;United States;uptake;Urine;Vesicle;Western Blotting

PROJECT_TITLE: Role of exosomes in ethanol-induced neurotoxicity

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Cancer;Prevention

PHR: Project Narrative This project will provide researchers studying carcinogenesis and chemoprevention with advanced analytical tools to advance their research goals. It will help them to advance the understand of how cancer is initiated and use this information to develop strategies for cancer prevention and/or treatment of cancer.

PI_NAMEs: VILLALTA, PETER WILLIAM (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: advanced analytics;Analytical Biochemistry;analytical tool;Biological Markers;Cancer Center;cancer prevention;cancer therapy;carcinogenesis;Carcinogenesis Mechanism;Chemicals;Chemoprevention;Collaborations;Comprehensive Cancer Center;Consultations;Dependence;Financial Support;Freedom;Funding;Goals;Group Meetings;Knowledge;Laboratories;Malignant Neoplasms;Manuscripts;Mass Spectrum Analysis;Measurement;member;Methods;Minnesota;Molecular;National Cancer Institute;Prevention program;Principal Investigator;programs;Public Health;Research;Research Personnel;Resource Sharing;Series;Services;Source;Training;Universities;University resources;working group;Writing

PROJECT_TITLE: Mass Spectrometric Analytical Collaborations with Members of the Carcinogenesis and Chemoprevention Program of the University of Minnesota Masonic Cancer Center


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation

ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease), or other disorders can become unable to speak despite being awake and alert. In this project, we seek a fundamental understanding of how the brain produces speech, and to develop an intracortical brain-computer interface (iBCI) to restore communication at conversational speeds by people with paralysis.

PI_NAMEs: DRUCKMANN, SHAUL ;HENDERSON, JAIMIE M (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Address;Amyotrophic Lateral Sclerosis;Area;arm;arm movement;Articulators;Augmentative and Alternative Communication;automated speech recognition;awake;Brain;brain computer interface;Brain Stem Infarctions;Broca's area;Chronic;Clinical Research;Clinical Trials;Communication;communication device;Computers;Custom;deep learning;design;Devices;Dimensions;Disease;Dorsal;dynamic system;Electrocorticogram;Electrodes;experience;Face;Functional Magnetic Resonance Imaging;Gestures;Goals;Hand;Handwriting;Human;Impairment;Implant;improved;Individual;Inferior frontal gyrus;insight;Intention;Investigation;kinematics;Language;Learning;Locked-In Syndrome;Macaca;Machine Learning;machine learning algorithm;Methods;Microelectrodes;Modeling;Modernization;Motor;Motor Cortex;motor impairment;Movement;Muscle;National Institute on Deafness and Other Communication Disorders;Nervous System Disorder;neural;neural correlate;Neurodegenerative Disorders;neuromechanism;Neurons;neuroregulation;Neurosciences;nonhuman primate;orofacial;Output;Paralysed;Participant;Performance;Persons;Population;Population Dynamics;Precentral gyrus;Preparation;Production;Prosthesis;Quality of life;recurrent neural network;Reporting;Research;Research Support;Safety;safety assessment;Signal Transduction;Site;Speech;speech accuracy;Speed;System;Techniques;Technology;Testing;Text;Time;training data;Utah;Voice;Writing

PROJECT_TITLE: Single-neuron population dynamics in human speech motor cortex for a speech prosthesis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Pediatric;Rare Diseases

ORG_CITY: BANGALORE

ORG_COUNTRY: INDIA

ORG_FIPS: IN

ORG_NAME: INDIAN INSTITUTE OF SCIENCE

PHR: PROJECT NARRATIVE The proposed research is relevant to the call for International Research in Infectious Diseases and deals with diarrheal diseases mediated by heat-stable enterotoxins, a major cause of infectious diarrhea in children and travelers to developing countries. Our proposed studies aim to use a novel transgenic mouse model to elucidate the changes that occur in the gut during a prolonged secretory state, delineate the consequences of zinc therapy and increased susceptibility to infection by bacterial pathogens. This research will have the potential to reveal novel downstream targets that target diarrheal disease and its sequalae.

PI_NAMEs: VISWESWARIAH, SANDHYA  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Affect;Animals;Antibodies;Autophagocytosis;Bacterial Infections;Binding;burden of illness;Cell Line;Cell Physiology;Cell Surface Receptors;cell type;Cells;Child;Childhood;Chlorides;Chronic;Citrobacter rodentium;co-infection;Colon;Communicable Diseases;Cyclic GMP;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Defect;Developing Countries;Diarrhea;diarrheal disease;Disease Progression;efficacy evaluation;Engineering;Enteral;enteric infection;enteropathogenic Escherichia coli;enterotoxigenic Escherichia coli;enterotoxin receptor;Enterotoxins;Environment;Epithelial Cells;Escherichia coli Infections;Face;Flow Cytometry;Fluids and Secretions;Functional disorder;Genes;genetic signature;Goals;Growth;Gut associated lymphoid tissue;gut inflammation;Immune;In Vitro;in vivo;in vivo imaging;in vivo monitoring;India;Infection;Inflammation;Inflammatory;inflammatory marker;Innate Immune System;Integrins;Interferons;International;intestinal epithelium;Intestines;intraepithelial;Ions;Knock-in Mouse;Laboratories;Lymphocyte;Mediating;Molecular;Monitor;Morbidity - disease rate;mortality risk;mouse model;Mus;Mutation;novel;novel therapeutic intervention;Oral Administration;Organoids;Outcome;Output;Paneth Cells;pathogen;Pathogenesis;pathogenic bacteria;Pathology;Pathway Analysis;Phenotype;Phosphorylation;Physiology;Pre-Clinical Model;Predisposition;recruit;reduce symptoms;Research;response;Role;Salts;Signal Transduction;Small Intestines;Sodium;Sodium-Hydrogen Antiporter;STAT1 gene;T-Lymphocyte;targeted treatment;Testing;Th1 Cells;Therapeutic;Toxin;transcriptome sequencing;Transgenic Mice;wasting;Zinc;Zinc Sulfate

PROJECT_TITLE: Mechanisms underlying diarrhea and gut inflammation mediated by Enterotoxigenic and Enteropathogenic E. coli

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Genetics;Nutrition;Obesity;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Project Narrative Approximately 40% of the US adult population is obese, and a greater part of them suffer from T2DM. VSG bariatric surgery is currently our most effective strategy at sustained weight loss over 10 years and leads to a 40% remission of T2DM, where patients can be completely removed from diabetic medications. This research project proposes a study that is finding endogenous factors and the molecular mechanism(s) underpinnings enteroendocrine cell differentiation to induce the gastrointestinal environment similar to that of VSG, consequently, replicate the surgical outcome with non-invasive treatment.

PI_NAMEs: KIM, KI SUK  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Address;Adult;Affect;Agonist;bariatric surgery;Bile Acids;Biology;blood glucose regulation;Body Weight;Body Weight decreased;career;career development;Cell Differentiation process;Cell secretion;Cells;Cholecystokinin;Colorado;Communication;Data;Development;diabetic;diet-induced obesity;Disease remission;Eating;Endocrine system;Endocrinology;Endogenous Factors;Energy Metabolism;Enteroendocrine Cell;Environment;Epithelial Cell Proliferation;Epithelial Cells;fexaramine;Foundations;Funding;Gastrectomy;Gastric Inhibitory Polypeptide;gastrointestinal;Gene Expression;Gene Family;Genes;Genetic;genetic manipulation;glucagon-like peptide 1;Goals;Grant;Homeostasis;Hormones;Human;human tissue;improved;in silico;In Vitro;in vivo;intestinal epithelium;Intestines;Knockout Mice;Knowledge;Label;Lead;Mediating;Medical;Mentored Research Scientist Development Award;Metabolic;Metabolism;Modeling;Molecular;Monitor;Morphology;mouse genetics;mouse model;Mouse Strains;Mus;Non-Insulin-Dependent Diabetes Mellitus;notch protein;novel;Obesity;obesity treatment;Operative Surgical Procedures;Organoids;Outcome;Patients;Peptide YY;Peptides;Pharmaceutical Preparations;pharmacologic;Physiology;Population;progenitor;programs;Publishing;receptor;Receptor Signaling;Regulation;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;Rodent;Role;Satiation;Science;Secretory Cell;sham surgery;Signal Transduction;skills;stem cell biology;stem cell fate;stem cell homeostasis;stem cells;success;surgery outcome;Tamoxifen;Testing;tool;Training Activity;transcriptome sequencing;transcriptomics;Translations;treatment response;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: The role of enteroendocrine cell differentiation in the success of bariatric surgery


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetics;HIV/AIDS;Infectious Diseases;Lung;Lung Cancer;Precision Medicine;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_DEPT: PSYCHIATRY

PHR: Smoking among PLWHA is a critical public health issue, with the rate of smoking 2-3 times greater than it is in the general population and the health risks of smoking outweighing those associated with the virus itself. Unfortunately, remarkably few studies have evaluated smoking cessation interventions for PLWHA and the available literature indicates that both behavioral and pharmacological smoking cessation interventions yield modest effect sizes and quit rates that are considerably lower than in the general population. A sizable literature, including studies by our research team, indicates that using the nicotine metabolite ratio (which represents the speed at which smokers metabolize nicotine; NMR) to personalize the selection of medications for tobacco use and the MAPS intervention to augment adherence to these medications can optimize treatments for tobacco use among PLWHA. As such, this trial will test these intervention optimization strategies to determine if individually or together these interventions can represent an effective approach to treating tobacco use in this population of smokers. As a major advance for this area of work, we will use rigorous methodology to evaluate these optimization strategies (i.e., a randomized design, biological verification, an ITT approach, and 6-month outcome assessments) and, overall, our approach is consistent with the MOST framework, which has been used to identify intervention components that maximize cessation outcomes. This trial will also assess theoretically derived and empirically based mechanisms through which these optimization strategies affect cessation and explore sub- groups who are more or less responsive to these strategies. In the end, this trial will determine if getting the right medication to the right person and helping to make sure they adequately use the medication optimizes tobacco cessation treatments among PLWHA in order to improve health outcomes for this population.

PI_NAMEs: GROSS, ROBERT ;SCHNOLL, ROBERT ADAM (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, ANNETTE R

PROJECT_TERMS: Address;Adherence;Affect;Aftercare;Age;antiretroviral therapy;Area;Behavior Therapy;Behavioral;Biochemical;Biological;Budgets;Cardiovascular Diseases;CD4 Lymphocyte Count;Characteristics;Clinical Trials;Combined Modality Therapy;Control Groups;Counseling;Data;Dependence;design;Effectiveness;efficacious intervention;Evaluation;Evidence based intervention;Expectancy;follow-up;France;Gender;General Population;genetic variant;Health;Hepatitis C Therapy;HIV;HIV Infections;HIV/AIDS;improved;indexing;Individual;individualized medicine;Intervention;Life;Life Expectancy;Literature;Malignant Neoplasms;Mediating;Mediator;medication compliance;Mental Depression;Metabolism;Methodology;Modeling;modifiable risk;Motivation;multiphase optimization strategy;Nicotine;nicotine patch;nicotine replacement;nicotine use;novel;Outcome;Outcome Assessment;Participant;personalized approach;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacogenetics;pharmacologic;Pharmacotherapy;placebo controlled trial;Population;Prevalence;Problem Solving;prospective;psychiatric comorbidity;Public Health;Race;Randomized;randomized, clinical trials;Reporting;Research;Risk;Risk Factors;Safety;Self Efficacy;Sex Orientation;side effect;Site;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;Speed;standard care;Subgroup;substance use;systematic review;Testing;therapy adherence;Tobacco;tobacco abstinence;tobacco cessation intervention;Tobacco Dependence;Tobacco smoking behavior;Tobacco use;Tobacco Use Cessation;Toxic effect;Treatment Effectiveness;Treatment Efficacy;treatment optimization;Treatment outcome;treatment research;Underserved Population;varenicline;Variant;Virus;Work

PROJECT_TITLE: Testing Novel Pharmacogenetic and Adherence Optimization Treatments to Improve the Effectiveness of Smoking Cessation Treatments for Smokers with HIV


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed study combines computational neuroimaging with psychophysics to identify the neural mechanism by which interocular inhibition leads to perceptual deficits in anisometropic amblyopia. This research aims to use models of cortical processing to inform targeted outcome measures that will improve the evaluation of amblyopia therapies. Furthermore, this additional neural characterization of amblyopia deficits will lead to the development of new treatments that specifically target frequency-dependent interocular inhibition of the amblyopic eye.

PI_NAMEs: WIECEK, EMILY  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Affect;Alternative Therapies;Amblyopia;Area;Attenuated;behavior measurement;Behavioral;Binocular Vision;Boston;career;career development;Childhood;Clinical;Clinical Research;clinical translation;Code;Competence;Computer Models;Contralateral;Contrast Sensitivity;Darkness;Data;design;Development;developmental disease;Discrimination;Employment;Environment;Evaluation;experience;Experimental Designs;Experimental Models;Eye;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Goals;Human;Imaging technology;Impairment;improved;Knowledge;luminance;Maps;Masks;Measures;medical schools;Mentored Research Scientist Development Award;Mentors;Mentorship;Modeling;monocular;National Eye Institute;neural;neural correlate;neurodevelopment;neuroimaging;neuromechanism;neurophysiology;novel;Outcome Measure;Participant;Pediatric Hospitals;Perception;Performance;Population;Psychophysics;Research;Research Design;Research Priority;response;Scientist;Secondary to;Signal Transduction;Stimulus;Techniques;Training;Universities;Vision;Vision Disorders;Visual;visual coding;visual information;visual processing;Visual Psychophysics;visual stimulus;Visual System;Work

PROJECT_TITLE: Spatial Frequency Dependent Deficits in Anisometropic Amblyopia


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Brain injury is a major risk factor for the delayed onset of parkinsonism, an issue of critical importance for veterans, many of whom have experienced brain injury as a result of exposure in combat. Very little is known, however, about the clinical or pathological features of parkinsonism related to brain injury. Patients with parkinsonism with and without a history of brain injury will undergo rigorous prospective clinical characterization of their neurological, psychological, cognitive, and other symptoms. In addition, postmortem analysis will be performed on a combination of existing brain tissue and tissue from a subset of subjects in this cohort to determine the neuropathological correlates of brain injury. Qualitative and quantitative evaluations will focus upon alpha-synuclein, the core protein involved in PD, and tau, a protein that is deposited in chronic traumatic encephalopathy and other neurodegenerative disorders. These findings, and the observed correlation between the clinical and neuropathological features, will provide valuable insights into the long-term sequelae of brain injury.

PI_NAMEs: NIRENBERG, MELISSA J;WALKER, RUTH HELEN (contact)

PROJECT_TERMS: abnormally phosphorylated tau;Age of Onset;agent orange;alpha synuclein;Alzheimer's Disease;Amyloid beta-Protein;Autopsy;Behavioral;Biological Markers;Brain;Brain Injuries;brain tissue;Caring;Characteristics;Chronic;chronic traumatic encephalopathy;cigarette smoking;Clinic;Clinical;clinical biomarkers;clinical development;clinical diagnostics;clinical examination;clinical phenotype;Code;Cognitive;Cognitive deficits;cohort;Collection;combat;Complication;Core Protein;Craniocerebral Trauma;Data;Dementia;Deposition;Development;Diagnosis;diagnostic biomarker;Diffuse;Diffuse Lewy Body Disease;Disease;dopaminergic neuron;Economic Burden;Environmental Exposure;Epidemiology;experience;Family member;Freedom;Frequencies;Health;Human;Impaired cognition;Incidence;Individual;Injury;insight;Interview;Knowledge;Light;Literature;long-term sequelae;Malignant - descriptor;Measures;Mechanical Stress;Medical Records;mild traumatic brain injury;military veteran;morphological criteria;Motor;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Nature;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;neurofilament;neuroinflammation;Neurologic;Neurologic Symptoms;Neurology;neuropathology;neuropsychiatric symptom;Neurotransmitters;novel diagnostics;operation;Orthostatic Hypotension;Paralysed;Parkinson Disease;Parkinsonian Disorders;Pathologic;Pathology;Patients;Pattern;Phenotype;Play;Population;Prevalence;prion-like;Process;Prognosis;progressive neurodegeneration;Progressive Supranuclear Palsy;prophylactic;prospective;Prospective cohort;protein TDP-43;Proteins;psychiatric symptom;psychologic;Qualitative Evaluations;Quantitative Evaluations;Questionnaires;rational design;Recording of previous events;recruit;REM Sleep Behavior Disorder;Reporting;Research;Resources;Risk Factors;Role;Serum;Severities;Severity of illness;social;subconcussion;Symptoms;synuclein;synucleinopathy;tau Proteins;tau-1;Tauopathies;Therapeutic Intervention;Time;Tissues;Traumatic Brain Injury;United States Department of Veterans Affairs;Veterans

PROJECT_TITLE: Clinical and Neuropathological Characterization of Parkinsonism Related to TBI in Veterans (CANPARK-TBI)


ORG_NAME: RLR VA MEDICAL CENTER

PHR: Chronic wounds, like those seen in patients with diabetes mellitus, are an important cause of morbidity (e.g. leg amputation) and, in some cases, mortality in Veterans. Research is needed to understand how these wounds form and to identify new therapies for prevention and treatment. Skin injury activates a complex inflammatory cascade (skin injury-induced inflammation) for host defense (from infection) and wound healing. This project will investigate how exuberant or dysfunctional skin injury-induced inflammation may contribute to impaired wound healing in diabetes, which could lead to better ways to treat and prevent chronic wounds. The proposed studies will use basic science, preclinical and translational approaches and next generation sequencing technology to gain a detailed understanding of skin injury-induced inflammation and will study the role of specific inflammatory proteins (that could represent future therapeutic targets) in this process.

PI_NAMEs: TURNER, MATTHEW J (contact)

PROJECT_TERMS: Acute;Alleles;Amputation;antagonist;Antibody Therapy;Basic Science;Biopsy Specimen;Blood Glucose;Cells;Cessation of life;Chronic;chronic wound;Cicatrix;Clinical;Complex;Coupled;Data;db/db mouse;defined contribution;Development;diabetes control;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;Diabetic mouse;diabetic patient;diabetic ulcer;diabetic wound healing;Disease;Endothelial Cells;Enrollment;Fibroblasts;Fibrosis;Fostering;Future;Gene Targeting;Genetic Crosses;glycemic control;Glycosylated hemoglobin A;Histologic;Host Defense;Human;human subject;IL1R1 gene;Impaired wound healing;Impairment;improved;improved outcome;Infection;Infectious Skin Diseases;Inflammation;Inflammatory;Inflammatory Response;insight;Interleukin-1;Interleukin-1 alpha;Interleukin-1 Receptors;keratinocyte;Knockout Mice;Knowledge;Leg;Link;Macrophage;Mechanics;Mediating;Medical;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;mouse model;mRNA sequencing;Mus;neutralizing antibody;next generation sequencing;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutics;Osteomyelitis;Outcome;Pathogenesis;Patients;Phase;Physiological;pre-clinical;prevent;Prevention therapy;Process;Proteins;Receptor Signaling;Research;research and development;Resolution;response;Risk Factors;Role;Signal Transduction;single-cell RNA sequencing;Skin;skin biopsy;Skin injury;Skin Tissue;Skin wound healing;Source;Stromal Cells;targeted treatment;Technology;therapeutic target;Tissues;transcriptome;translational approach;Veterans;Work;wound;wound closure;wound healing;Wound models

PROJECT_TITLE: Role of skin injury-induced inflammation in wound healing


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Our proposal seeks to reduce women's health disparities by investigating bladder health across diverse populations. Our multidisciplinary team will work together to use both qualitative and quantitative methods to understand factors that predict bladder health over time. This research will set a strong foundation for prevention trials in diverse populations of women to improve quality of life across the lifespan.

PI_NAMEs: GRIFFITH, JAMES WILLIAM (contact);SIMON, MELISSA A.

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Activities of Daily Living;adolescent woman;Adult women;Affect;Age;Assessment tool;Behavior;behavior influence;Biological;Biology;Bladder;Clinical;Clinical Research;clinical research site;cohort;Cohort Studies;common symptom;community engaged research;community engagement;community organizations;community partners;community partnership;Data;Dedications;demographics;Development;Discrimination;Disparity;Economic Burden;Education;Employment;Enrollment;Environmental Risk Factor;Epidemiology;epidemiology study;ethnic minority;Ethnic Origin;Evaluation;experience;Foundations;Future;Goals;Gynecologist;Health;health disparities in women;health disparity;Health Insurance;health literacy;Healthcare Systems;Heterogeneity;High Risk Woman;implementation science;implementation study;implicit bias;improved;Income;Institution;Insurance Coverage;Interview;knowledge base;Leadership;Letters;life span;Literature;Longitudinal cohort study;longitudinal design;Longitudinal, observational study;lower urinary tract symptoms;Measurement;Measures;Medical;Medical center;Methodology;Methods;Mind;Minority;Minority Groups;minority health;Minority Women;Morbidity - disease rate;multidisciplinary;Not Hispanic or Latino;novel;Outcome;Participant;Pathway interactions;physical state;Population;Population Heterogeneity;Predictive Factor;prevent;Prevention;Prevention program;Prevention trial;programs;prospective;protective factors;Psyche structure;psychologic;Psychologist;psychosocial;Quality of life;Race;racial minority;recruit;Research;Research Personnel;Respondent;response;Risk Factors;Sampling;screening;Screening procedure;Sensitivity and Specificity;Sex Orientation;Site;social;social health determinants;Social Well-Being;Societal Factors;Specificity;success;Symptoms;Time;Translating;United States National Institutes of Health;Universities;urinary;Vulnerable Populations;White Women;Woman;Work;Workplace

PROJECT_TITLE: NORTHWESTERN UNIVERSITY PLUS CLINICAL SITE


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Urologic Diseases;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Lower urinary tract symptoms (LUTS) affect millions of women and girls, have a major negative impact on quality of life, and are a source of economic burden. The majority of individuals with LUTS do not seek care; thus, to decrease suffering and health care costs, a shift towards the study of bladder health (BH) is urgently needed. Our approach will assess risk and protective factors related to BH using qualitative and quantitative methods and determine if the urogenital microbiome is a viable target for future prevention studies.

PI_NAMEs: LACOURSIERE, DAPHNE YVETTE;LUKACZ, EMILY S. (contact)

PROJECT_TERMS: Address;Adolescent;adolescent woman;Adult women;Affect;Age;Attitude;Basic Science;Behavioral;Behavioral Research;Belief;bilingualism;Biological;Biological Factors;Bladder;Child Care;Clinical;Clinical and Translational Science Awards;clinical care;clinical center;clinical practice;Clinical Research;clinical research site;Clinical Sciences;clinical translation;Clinical Trials;Clinical Trials Design;cohort;Collaborations;Collection;Communicable Diseases;Communities;community engagement;Conduct Clinical Trials;Data;Data Analyses;Data Coordinating Center;Dedications;design;Development;Device or Instrument Development;Discipline of obstetrics;Disparity;Doctor of Philosophy;Doctor of Public Health;Economic Burden;Elements;Epidemiologist;Epidemiology;epidemiology study;ethnic diversity;Ethnic Origin;Evidence based intervention;experience;Feasibility Studies;Fellowship;Female;Focus Groups;Fostering;Foundations;Funding;Future;General Population;Genitourinary system;Geography;girls;Goals;Gynecologist;Gynecology;Habits;Health;Health behavior;Health Care Costs;health disparity;Health education;Health Promotion;Hispanic;Human Microbiome;Human Resources;improved;Incidence;Individual;infancy;innovation;Institution;instrument;International;Intervention Studies;Intervention Trial;Investigation;Knowledge;Laboratories;Laboratory Research;Language;Latina;Lead;Leadership;Life Cycle Stages;Linguistics;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;lower urinary tract symptoms;Measures;Mediating;Medicine;member;Methods;Mexican Americans;microbiome;microbiome analysis;microbiome research;Modeling;modifiable risk;multidisciplinary;novel;Obesity;Participant;Pathway interactions;Patient Recruitments;pediatrician;Pediatrics;Pelvis;Physicians;Pilot Projects;population based;Population Heterogeneity;Prevalence;Prevention;Prevention Research;Primary Care;programs;protective factors;Protocols documentation;psychosocial;Public Health;Public Health Practice;public health research;Qualitative Research;Quality of life;Questionnaires;racial diversity;Reconstructive Surgical Procedures;Recording of previous events;recruit;Research;Research Design;research facility;Research Institute;Research Personnel;Resources;Risk Assessment;Risk Factors;Running;Science;Scientist;Site;skills;Societal Factors;Source;Spanish;Spanish/English;Specimen;Surveys;Therapeutic;Time;Training;Translational Research;Translations;Underrepresented Minority;United States National Institutes of Health;Urinary tract;Urine;Validation;Woman;Work;working group;young adult

PROJECT_TITLE: Prevention of LUTS: Bladder Health Clinical Center, UC San Diego Site


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: MOUNTAIN VIEW

ORG_NAME: ASTRAEA THERAPEUTICS, LLC

PHR: NARRATIVE  This project proposes to conduct lead optimization and preclinical development of novel compounds targeted to the nociceptin opioid peptide (NOP) receptor, as potential next generation pharmacotherapy to treat opioid use disorders and curbing prescription opioid addiction, and as non-addicting analgesics for chronic pain. The novel lead candidates developed on this project have the potential to address two critical aspects of the prescription opioid crisis– an approach to reduce prescription opioid addiction and relapse and provide new safer analgesics that lack abuse potential.

PI_NAMEs: ZAVERI, NURULAIN T (contact)

PROGRAM_OFFICER_NAME: WHITE, DAVID A

PROJECT_TERMS: abuse liability;addiction;Address;Agonist;Alcohols;Analgesics;Analytical Chemistry;Attenuated;Biological Assay;Buprenorphine;Chemicals;Chronic;chronic pain;Clinical;Clinical Research;Cocaine;craving;Cyclic GMP;Data;Dependence;design;Development;Documentation;Dose;drug candidate;Drug usage;Evaluation;Formulation;Goals;Heroin;illicit opioid;In Vitro;in vivo;Intake;Intellectual Property;kappa opioid receptors;Laboratories;Lead;lead candidate;lead optimization;Ligands;Lymphoma;Macaca mulatta;medication for opioid use disorder;meetings;Methadone;methadone clinic/center;method development;Micronucleus Tests;Monkeys;Morphine;mu opioid receptors;Mus;next generation;nociceptin;nonhuman primate;novel;novel strategies;Opioid;Opioid agonist;Opioid Antagonist;opioid epidemic;Opioid Receptor;opioid use disorder;Oral;ORL1 receptor;Overdose;Oxycodone;oxycodone self-administration;Pain;Peptide Receptor;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phase;Phase I Clinical Trials;Physical Dependence;pre-clinical;preclinical development;Preparation;prescription opioid;prescription opioid addiction;Process;Property;Recovery;Relapse;response;reward circuitry;Rewards;Risk;Rodent;Safety;safety study;scaffold;scale up;Secure;Series;small molecule;Telemetry;Toxic effect;Toxicokinetics;Toxicology;Training;Validation;Ventilatory Depression;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Development of Next-generation Pharmacotherapy for Opioid Use Disorders


NIH_SPENDING_CATS: Aging;Bioengineering;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Despite large increases in screening in the past two decades, colorectal cancer remains the second leading cause of cancer death in the United States. Our research has shown that 60% of these deaths could be prevented by better use of available screening interventions. In this proposal, we use microsimulation modeling to evaluate and help prioritize interventions to further reduce the burden of colorectal cancer.

PI_NAMEs: KNUDSEN, AMY ;KUNTZ, KAREN M;LANSDORP-VOGELAAR, IRIS ;RUTTER, CAROLYN M;ZAUBER, ANN GRAHAM (contact)

PROGRAM_OFFICER_NAME: TATALOVICH, ZARIA

PROJECT_TERMS: Address;adenoma;Age;Algorithms;American;American Cancer Society;Area;Calibration;Cancer Control;Cancer Etiology;Cancer Intervention and Surveillance Modeling Network;Cancer Model;carcinogenesis;Cessation of life;Clinical;clinical practice;Collaborations;Colonoscopy;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;comparative;computer aided detection;Computer software;cost;cost effectiveness;Country;Data;deep learning;Development;Diagnosis;Disparity;Economics;Effectiveness;Evaluation;experience;Failure;genomic biomarker;Genomics;Goals;Health Policy;Hemoglobin;High Performance Computing;improved;Incidence;Income;insight;International;Intervention;Knowledge;Literature;machine learning method;Malignant Neoplasms;member;Methods;Modality;Modeling;models and simulation;Natural History;New Hampshire;novel;Outcome;Pathway interactions;Pattern;personalized medicine;personalized screening;Persons;Philosophy;Policies;Polyps;Population;population based;Population Research;Positioning Attribute;prevent;Process;Regimen;Registries;Reporting;Research;Resources;Risk;Role;screening;Screening for cancer;screening guidelines;screening participation;screening program;Seminal;sex;Structure;Subgroup;surveillance strategy;Technology;Testing;Time;tool;trend;Uncertainty;United States;Update;uptake;Work

PROJECT_TITLE: Comparative Modeling of Effective Policies for Colorectal Cancer Control


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative  Ultrasound is the most utilized imaging modality, and echocardiography itself accounts for nearly a ﬁfth of all imaging exams. Unfortunately, for many diagnostic tasks, ultrasound exams are suboptimal or fail altogether. To resolve this, we introduce a new framework for both coded excitation and deep network beamforming and evaluate our methods in the context of transthoracic echocardiography of the left atrial appendage.

PI_NAMEs: BYRAM, BRETT C (contact);EAGLE, SUSAN

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acoustics;Address;Algorithms;American;appendage;Atrial Fibrillation;auricular appendage;Chest;Chronic;Clinical;clinical translation;clinically relevant;Clutterings;Code;Consumption;cost;Data;deep neural network;Development;Devices;Diagnosis;Diagnostic;Echocardiography;Electric Countershock;Ensure;Esophagus;Exclusion;Failure;flexibility;Goals;Healthcare Systems;Heart;Heart Atrium;Heart Diseases;Image;imaging modality;imaging study;implantable device;improved;in silico;in vivo;Incidence;innovation;insight;Left;Left atrial structure;Length;Link;Magnetic Resonance Imaging;Measures;Methods;Modality;Modeling;Monitor;monitoring device;Nature;Noise;Patients;Penetration;Performance;Physicians;Play;Procedures;radiological imaging;reconstruction;Role;Safety;Scheme;screening;second harmonic;Sensitivity and Specificity;Signal Transduction;Sinus;skills;Sound Localization;Source;Speed;standard of care;success;Testing;Thrombus;Time;tool;Training;Transesophageal Echocardiography;transmission process;Ultrasonics;Ultrasonography;ultrasound;United States;Variant;Visualization;Work

PROJECT_TITLE: Ultrasound clutter and noise improvements applied to echocardiographic left atrial appendage visualization

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Glycosylation is an essential, post-translational protein modification with complex and poorly understood roles in protein function. This project utilizes a mouse model and glycoproteomics to identify the cellular and molecular origin of neurological dysfunction in a rare disease (GALNT2-CDG) caused by genetic defects in a critical glycosyltransferase protein that initiates the first step in mucin-type O-glycosylation. Understanding glycosylation in the nervous system will elucidate the pathophysiology of rare genetic diseases that disrupt glycosylation (known as congenital disorders of glycosylation) as well as other neurological diseases, enable therapeutic advances targeting glycosylation pathways, and inform normal functions of glycosylation.

PI_NAMEs: EDMONDSON, ANDREW CHARLES (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Affect;Alleles;Astrocytes;behavioral phenotyping;Biology;Brain;career development;Career Mobility;Cell Line;cell motility;cell type;Cells;Cellular Morphology;comparative;Complex;conditional knockout;Congenital disorders of glycosylation;Constitution;design;Development;Development Plans;Disease;Epilepsy;Event;Exhibits;Family member;Foundations;Functional disorder;Funding;Future;Genetic;Genetic Diseases;global developmental delay;Glycobiology;Glycoproteins;glycoproteomics;glycosylation;glycosyltransferase;Goals;Human;in vitro Assay;Individual;insight;International;Investigation;Knockout Mice;knowledgebase;LoxP-flanked allele;Mass Spectrum Analysis;Mediating;Mentors;Microcephaly;Modeling;Molecular;molecular phenotype;Morphology;motor deficit;mouse model;Mucins;Mus;Mutation;Nervous System;Nervous System Disorder;Nervous System Physiology;neural;Neurobiology;Neurologic Deficit;Neurologic Dysfunctions;Neurons;Neurosciences;neurotransmitter release;Pathway interactions;Patients;Phenotype;Physicians;Post-Translational Protein Processing;Process;programs;protein function;Protein Isoforms;Proteins;Rare Diseases;rare genetic disorder;Research;Role;Scientist;sensory integration;Signal Transduction;Site;skills;Symptoms;Techniques;Therapeutic;tool;Training

PROJECT_TITLE: O-glycosylation mechanisms of neurological deficits in congenital disorders of glycosylation

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE More robust and accurate health knowledge is a cornerstone of better health policy and action. Results from experimental and observational HIV studies can be made better and more policy-relevant through development and use of new methods at the interface of statistics, epidemiology, causal inference, and artificial intelligence. In this work, we propose new and improved estimators of the risk (or survival) function.

PI_NAMEs: COLE, STEPHEN R (contact);EDWARDS, JESSIE

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: 17p;Acquired Immunodeficiency Syndrome;Address;AIDS clinical trial group;American;analog;arm;Artificial Intelligence;Caproates;causal model;clinical decision-making;cohort;Cohort Analysis;Collaborations;complex data;Computer software;Data;Data Analyses;data tools;design;Development;Educational workshop;efavirenz;Epidemiologist;Epidemiology;Event;experimental analysis;experimental study;Goals;Hand;health knowledge;Health Policy;HIV;Hydroxyprogesterone;improved;innovation;Integrase Inhibitors;interest;Lamivudine;Machine Learning;Masks;Medicine;Methodology;Methods;Modeling;Modernization;mortality;novel strategies;Observational Study;Odds Ratio;open source;Outcome Measure;Paper;Placebos;Policies;Population;Pregnant Women;Premature Birth;Probability;Programming Languages;Protocols documentation;Public Health;Publications;Randomized;Recording of previous events;Relaxation;Reproducibility;Research;Risk;semiparametric;Series;statistics;symposium;Testing;theories;tool;treatment comparison;Vertebral column;Women's cohort;Work

PROJECT_TITLE: Improved analysis of experiments and observational studies in HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]