NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Recovery Support Services;Rehabilitation;Substance Misuse

ORG_STATE: PA

PHR: PROJECT NARRATIVE Alcohol Use Disorder (AUD) recovery outcomes can be improved through peer-based social support but barriers to in-person support (e.g., 12-step groups) are high and became increasingly apparent through the COVID-19 pandemic. Online AUD Recovery Support (OARS) forums are growing in popularity and offer convenient access to real-time social support which can lead to improved well-being and transitions to in- person support, but effectiveness of OARS on improving AUD outcomes has not been studied in rigorous clinical trials. In order to stage the first clinical trials of OARS participation – ultimately leading toward evidence-based guidelines for their use in AUD – I will develop necessary measures of OARS behavior and conduct a pilot randomized clinical trial to assess the feasibility of a behavioral intervention for OARS participation.

PI_NAMEs: COLDITZ, JASON  (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: acceptability and feasibility;addiction;Adult;Alcohol consumption;alcohol seeking behavior;alcohol use disorder;Behavior;Behavior assessment;Behavior Therapy;Behavioral;behavioral clinical trial;behavioral construct;Behavioral trial;career;Classification;Clinical;Clinical Treatment;Clinical Trials;Clinical Trials Design;Code;Collaborations;Computing Methodologies;concept mapping;Conceptual Domain;Coping Skills;cost effective;COVID-19 pandemic;dashboard;Data;Data Reporting;deep learning;Development;Effectiveness;effectiveness evaluation;Emotional;evidence base;evidence based guidelines;experience;feasibility trial;Feedback;Focus Groups;Foundations;Frequencies;Funding;Goals;Health;health science research;Health Services Accessibility;Heterogeneity;Human;human centered design;improved;insight;instrument;Intervention;Learning;Measurement;Measures;Mentors;Mentorship;Methods;Modeling;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;Natural Language Processing;new technology;Observational Study;online intervention;Outcome;Participant;Pathway interactions;Patient Self-Report;Pattern;peer;peer support;Personal Satisfaction;Persons;Procedures;Process;prospective;Psychological reinforcement;Psychometrics;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Recovery;Recovery Support;Research;Research Personnel;social;Social Identification;social media;social observations;Social Processes;Social support;Statistical Data Interpretation;Structure;Surveys;Technology;Text;therapy development;Time;tool;Training;Work

PROJECT_TITLE: Toward measures and behavioral trials for effective online AUD recovery support

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Nutrition;Physical Activity;Physical Rehabilitation;Prevention;Prostate Cancer;Rehabilitation;Telehealth;Urologic Diseases

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Androgen deprivation therapy (ADT), with an androgen signaling inhibitor, is the backbone of treatment for men with metastatic castration sensitive prostate cancer (mCSPC), but diminished muscle mass due to androgen blockade is linked with poor overall survival, and adverse changes in health outcomes important to mCSPC survivors (e.g., fatigue, physical function, independence, insulin sensitivity, and quality of life). Resistance training (RT) is an effective approach to preserve muscle mass and improve these health outcomes in non-metastatic CSPC survivors receiving ADT; however, there is a gap in our understanding of how RT impacts outcomes in mCSPC survivors, and the impact of 52-weeks of RT in a home-based setting, a setting that is more practical for sustained adherence and the reported preferred setting for exercise in mCSPC survivors receiving ADT. Furthermore, the addition of creatine monohydrate supplementation to an RT program (Cr+RT) enhances the effects of RT in cancer-free older adults and individuals with advanced head and neck cancer, and creatine supplementation has demonstrated anti-cancer effects in preclinical models including prostate cancer; as such, this 52-week, randomized, double-blind placebo-controlled trial will compare our established, effective, home-based, telehealth RT program with creatine or placebo (PLA; Cr+RT vs. PLA+RT) in order to identify the superior strategy to preserve muscle mass, improve health outcomes, and attenuate cancer progression in mCSPC survivors receiving ADT.

PI_NAMEs: AGARWAL, NEERAJ ;COLETTA, ADRIANA  (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Address;Adherence;Adopted;Advanced Malignant Neoplasm;analog;androgen deprivation therapy;Androgens;anti-cancer;Attenuated;cancer biomarkers;cancer survival;Cancer Survivorship;cancer therapy;Caring;Castrate sensitive prostate cancer;cell free DNA;chemotherapy;Clinical;Colorectal Cancer;Complement;Creatine;Disease;Double-Blind Method;double-blind placebo controlled trial;Dual-Energy X-Ray Absorptiometry;Educational Intervention;Effectiveness;efficacy testing;Elasticity;Energy Metabolism;Exercise;exercise capacity;exercise training;Exhibits;Fatigue;Fatty acid glycerol esters;Head and Neck Cancer;Health;Home;improved;Incidence;Individual;inhibitor;Institution;insulin sensitivity;Intervention;intervention effect;Intervention Studies;Knowledge;Life Style;Link;Literature;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Metastatic Prostate Cancer;Modeling;muscle form;Nonmetastatic;older adult;Older Population;Outcome;patient oriented;Phosphocreatine;Physical Function;Physical Performance;Placebos;Play;Population;Pre-Clinical Model;preservation;primary outcome;Proliferating;prostate cancer survivors;Protocols documentation;Quality of Care;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;Research;Resistance;resistance exercise;Role;Safety;Signal Transduction;Skeletal Muscle;Supplementation;Survival Rate;Survivors;survivorship;System;telehealth;Telemedicine;Testing;Thinness;Training Programs;Translating;tumor growth;tumor progression;Vertebral column;week trial;Work

PROJECT_TITLE: Creatine supplementation and resistance training to preserve muscle mass and attenuate cancer progression: A double-blind randomized controlled trial


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE This proposed research is responding to RFA-DE-22-003 and aims to better understand the epidemiology and biology of oral HPV infection, as well as its acquisition and persistence, in people living with HIV (PLWH) and elucidate mechanisms related to HPV-associated oral and oropharyngeal cancers (OOPC) in the context of HIV. We propose to study the role of epigenetic biomarkers in HPV-associated OOPC in PLWH in Nigeria, a country with high HIV prevalence, to help develop potential non-invasive screening and early detection biomarkers of OOPC in PLWH. Identifying epigenetic markers predictive of the progression of precancerous lesions into OOPC will also provide opportunities for developing future preventive and therapeutic targets for managing precancerous lesions and OOPC in PLWH.

PI_NAMEs: HOU, LIFANG  (contact);MORHASON - BELLO, IMRAN ;MURPHY, ROBERT LEO

PROGRAM_OFFICER_NAME: LIDDELL HUPPI, REBECCA

PROJECT_TERMS: Africa;Africa South of the Sahara;Age;antiretroviral therapy;Area;Benign;Biological Assay;Biology;biomarker development;Biopsy;Biopsy Specimen;cancer biomarkers;Cancer Patient;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Count;Chronic;Clinical;co-infection;Code;cohort;Collaborations;college;cost effective;Country;Cytology;Data;Development;Diagnosis;Disease;DNA;DNA Methylation;DNA methylation profiling;early detection biomarkers;Early Diagnosis;Epidemiology;epigenetic marker;Epigenetic Process;Europe;Exogenous Factors;experience;follow-up;Funding;Future;Gene Expression;genome-wide;Genotype;Goals;hazard;Health care facility;High Prevalence;HIV;HIV Infections;Hospitals;HPV negative;HPV oropharyngeal cancer;HPV positive;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune system;Immune System Diseases;immunodeficiency;improved;Individual;Inflammation;Inherited;Intervention;Lesion;Literature;Longitudinal Studies;Malignant - descriptor;malignant mouth neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Medicine;methylation biomarker;Modification;Mouthwash;Nigeria;Nigerian;novel strategies;Oncogenic;oncology service;Oral;Oral cavity;oral HPV infection;Oral Sex;Outcome;Participant;Patients;Persons;predictive marker;Predisposition;premalignant;Prevalence;Prevention;Preventive;prognostic;progression risk;prospective;Public Health;Radiation Oncology;recruit;Research;Resources;Risk;Risk Factors;Role;Sampling;Satellite Hospitals;screening;Screening for cancer;sex;Sex Behavior;Site;specific biomarkers;Swab;Testing;therapeutic target;Tissues;transmission process;trend;tumor;United States;Universities;Viral;Viral Load result;Virus;young adult

PROJECT_TITLE: Epigenetic study of oral HPV infection-associated oral cancer in people living with HIV in Nigeria


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Chronic Pain;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Pain Research

ORG_CITY: BIDDEFORD

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NEW ENGLAND

ORG_STATE: ME

PHR: This proposal investigates neurons that transmit information related to corneal pain and determines how they are modified after corneal inflammation and nerve injury. Populations of corneal pain-activated neurons in the trigeminal ganglion and brainstem are characterized based on their gene transcription profiles, and the ability of corneal immune cells to interact and modify the properties of corneal neurons is examined. This comprehensive analysis will provide knowledge needed to develop new treatments for corneal pain and related disorders.

PI_NAMEs: HAMRAH, PEDRAM ;MENG, IAN D (contact);RENTHAL, WILLIAM RUSSELL

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acute;Address;Affective;Afferent Neurons;Anatomy;Aversive Stimulus;Behavior;Behavioral;Brain region;Brain Stem;Cell Nucleus;cell type;Cells;Chronic;chronic pain;Complex;Cornea;Corneal Diseases;Corneal Injury;Corneal pain;Data;Debridement;Disease;Dry Eye Syndromes;Electrophysiology (science);Endowment;epigenomics;Excision;experience;experimental study;Eye Injuries;Gene Expression Profile;Genetic Transcription;Health;Homeostasis;Human;Immune;In Situ Hybridization;In Vitro;Inflammation;Injury;interdisciplinary approach;Intervention;Knowledge;Lacrimal gland structure;Lateral;Leukocytes;Ligands;Measures;Messenger RNA;Molecular;Molecular Profiling;Motivation;Mus;Nerve;nerve damage;nerve injury;Neuroimmune;Neurons;Neuropathy;neurotransmission;Nociception;nociceptive response;Nociceptors;novel;ocular surface;optogenetics;Pain;pain behavior;pain model;parabrachial nucleus;Pathway interactions;Peripheral;Peripheral Nerves;Physiological;Population;Population Heterogeneity;Property;receptor;Regulation;Resolution;response;response to injury;Role;Signal Transduction;Structure of trigeminal ganglion;Structure of trigeminal nerve spinal tract nucleus;Tissues;Transcript;transcriptome

PROJECT_TITLE: Central and Peripheral Mechanisms of Corneal Pain


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE Hematopoietic stem cells (HSC) in the adult bone marrow are rare multipotent cells that can regenerate and sustain blood development upon transplantation. Strategies to "mobilize" HSC from the bone marrow to the peripheral blood show great promise to enhance the efficiency of stem cell transplantation. The proposed studies would address major gaps in our knowledge of basic HSC biology, and provide novel insights into the clinically relevant process of HSC mobilization.

PI_NAMEs: FOOKSMAN, DAVID R;REIZIS, BORIS  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Address;Adult;Affect;Animals;antagonist;Behavior;behavioral study;Blood;Blood Vessels;Bone Marrow;Bone Marrow Transplantation;Calcium;Calcium Signaling;cell behavior;cell motility;Cellular Morphology;chemokine;Clinic;clinically relevant;Collaborations;Complex;Computer Analysis;Computer Models;CXCR4 gene;CXCR4 Receptors;Development;Enterobacteria phage P1 Cre recombinase;Environment;Genetic;genetic analysis;genetic manipulation;Growth Factor;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Mobilization;hematopoietic stem cell niche;Hematopoietic stem cells;Hour;human old age (65+);Immunity;Impairment;in vivo;inducible Cre;Inflammation;Inflammatory;insight;Integrins;Interferons;intravital imaging;intravital microscopy;Knowledge;Label;Mediator;Molecular;Morphology;Motility;Mouse Strains;multiphoton imaging;multipotent cell;Mus;Natural regeneration;Nature;novel;Pathologic;peripheral blood;pharmacologic;Play;Process;ratiometric;reconstitution;Reporter;response;Role;sensor;Signal Transduction;stem cell biology;Stem Cell Factor;stem cell function;stem cell growth;stem cell homeostasis;Stem cell transplant;Stimulus;Stromal Cell-Derived Factor 1;Stromal Cells;System;Tamoxifen;Testing;Time;Transgenes;Transplantation;Visualization

PROJECT_TITLE: Intravital analysis of hematopoietic stem cells in their bone marrow niche - Resubmission - 1

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Rare Diseases;Regenerative Medicine;Wound Healing and Care

ORG_CITY: BOSTON

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

ORG_STATE: MA

PHR: NARRATIVE Currently, there are no effective non-surgical tools for preventing or treating corneal scarring, which is a complication often observed with advanced keratoconus (KCN) that results in possible blindness and decreased quality of life. Bioactive cargo (e.g., RNA, protein, and lipids) containing extracellular vesicles (EVs) are released by corneal cells to communicate with one another, and those released by the corneal epithelium can trigger myofibroblast differentiation, which may cause scarring and diminish vision if they persist. In this proposal, we will load-EVs with TGF-β1 or -β3 to determine a growth factor that can drive scar-free corneal wound healing, and we will examine the bioactive cargo from KCN-epithelial cell derived EVs that is contributing to KCN corneal scarring and disease progression.

PI_NAMEs: CIOLINO, JOSEPH B. (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Acute;Address;Automobile Driving;Basement membrane;Biological;Biological Markers;Biological Process;Biology;biophysical properties;Biophysics;Blindness;Cell Communication;Cell Line;Cell Lineage;cell motility;Cell Physiology;Cell Proliferation;Cells;Cellular Structures;Cicatrix;clinically relevant;Communication;Complex;Complication;Cornea;Corneal Diseases;corneal epithelial wound healing;corneal epithelium;Corneal Injury;corneal regeneration;corneal scar;Corneal Stroma;corneal surgery;cytokine;Deposition;Disease;Disease Progression;Elements;Epithelial Cell Proliferation;Epithelial Cells;Epithelial-Stromal Communication;Epithelium;Etiology;experimental study;Extracellular Matrix;extracellular vesicles;Fibroblasts;Fibrosis;Future;Generations;Genetic Markers;Growth Factor;healing;Homeostasis;Human;In Vitro;in vivo;Infection;Infiltration;Inflammation;Inflammatory;Injury;insight;interest;Keratoconus;Lipids;Mediating;Mediator;Messenger RNA;Modeling;Molecular;Myofibroblast;Natural regeneration;Oryctolagus cuniculus;paracrine;Pathogenesis;Pathologic;Pathway interactions;Patients;Penetrating Wounds;Penetration;phenotypic biomarker;Physiological;Pilot Projects;prevent;Process;Proliferating;Property;Protein Isoforms;Proteins;Proteomics;Public Health;Quality of life;repaired;Research;response;RNA;Role;Signal Pathway;Signal Transduction;Stromal Cells;Surgical Models;Testing;Therapeutic;Therapeutic Effect;Tissues;tool;Transforming Growth Factor beta;transforming growth factor beta3;Trauma;Validation;vesicular release;Visual impairment;wound healing;Wound models

PROJECT_TITLE: Corneal Epithelial-Stromal Interactions During Regeneration and Fibrosis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: NEW ORLEANS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Osteoporosis is a serious public health problem leading to severe bone loss and increased risk of fractures in elderly subjects. The proposed study will comprehensively identify genes, gut bacterial species, their products and functional mechanisms that are associated with differential susceptibility to osteoporosis. The findings will contribute to a better and more comprehensive understanding of molecular mechanisms, and thus help prevention and treatment, of osteoporosis.

PI_NAMEs: DENG, HONG-WEN  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;advanced analytics;Affect;Age;aging related disease;Bioinformatics;Biometry;bone;bone aging;Bone Density;bone loss;bone quality;Bone Resorption;bone strength;Cell Communication;Cell Lineage;Cells;Clinical;Complex;cost;Data;Data Set;Disease;disorder risk;DNA;DNA sequencing;Elderly;Environment;Environmental Risk Factor;Epigenetic Process;epigenome;epigenomics;Ethnic Origin;Etiology;Finite Element Analysis;follow-up;fracture risk;gene environment interaction;Gene Expression;gene regulatory network;Genes;Genetic;genetic information;Genetic Transcription;Genome;gut microbiome;Health;Human;human disease;Human Genome;in vivo;Individual;innovation;Institution;Light;Louisiana;Measures;Mediator;Messenger RNA;Metabolic;Metabolic Bone Diseases;metabolome;metabolomics;microbial genome;Molecular;Multiomic Data;multiple omics;next generation;novel;Osteoblasts;Osteoclasts;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Outcome;Pathway interactions;Phenotype;Predisposition;Prevention;Process;Productivity;Proteins;Proteome;Public Health;recruit;Resources;Risk;sex;single-cell RNA sequencing;Solid;Specificity;synergism;Technology;Testing;Time;tool;Trabecular Bone Score;transcriptome;Translating;United States National Institutes of Health;Variant;Volatile Fatty Acids

PROJECT_TITLE: Trans-omics Integration of Multi-omics Studies for Osteoporosis


PROJECT_TERMS: Adopted;African American population;bone;Bone Density;Budgets;caucasian American;Cells;Collaborations;Communication;cost effective;Data;data mining;data sharing;diversity and inclusion;DNA;Education;Educational Activities;Ensure;Environmental Risk Factor;epigenome;Ethnic Origin;Ethnic Population;Evaluation;expectation;experience;Faculty;Feedback;Female;Financial Support;Fostering;Funding;Genes;Genome;Genomics;Grant;gut microbiome;Health Sciences;Human Genome;Human Resources;IACUC;improved;in vivo;Individual;innovation;Institution;Institutional Review Boards;interdisciplinary approach;International;Joints;Leadership;lectures;male;Manuscripts;Measures;meetings;Mentors;metabolome;Metagenomics;microbiome;Monitor;multidisciplinary;Multiomic Data;multiple omics;novel strategies;operation;Osteoporosis;osteoporosis with pathological fracture;Plasma;Policies;Postdoctoral Fellow;Preparation;Problem Solving;Productivity;programs;Progress Reports;Protocols documentation;Quality Control;Recommendation;Records;Regulation;Reporting;Research;Research Personnel;Resource Sharing;Resources;Risk;risk variant;Role;Safety;Schedule;Science;Scientist;Services;sex;Specificity;student training;Students;symposium;transcriptome;Travel;United States National Institutes of Health;Volatile Fatty Acids

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This study is relevant to public health because it will prospectively examine the impact of disadvantageous neighborhood contextual factors (rooted in structural racism) and allostatic load (as an intermediate biological process/mechanism between neighborhood context and health) on breast cancer in a large, diverse study sample. The successful accomplishment of the proposed aims will contribute new knowledge about the impact of long-term exposures to disadvantageous neighborhoods and how chronic cumulative stress becomes biologically embedded in cells and tissues – thereby impacting breast cancer biology and etiology.

PI_NAMEs: ADAMS-CAMPBELL, LUCILE LAUREN;LLANOS, ADANA A. M. (contact)

PROGRAM_OFFICER_NAME: SIMONDS, NAOKO ISHIBE

PROJECT_TERMS: Address;allostatic load;Biological;Biological Factors;Biological Markers;Biological Process;Biology;biopsychosocial;Black race;black women;breast cancer diagnosis;Breast Cancer Risk Factor;Cancer Biology;cancer biomarkers;cancer epidemiology;Cancer Etiology;Cancer health equity;cancer prevention;cancer risk;Cardiovascular system;Cells;Chronic;Clinical;Clinical Data;cohort;Community Actions;contextual factors;cost;Cross-Sectional Studies;Data;deprivation;design;Development;Diagnosis;Diagnostic;Disease;Disparity;economic disparity;epidemiologic data;Ethnic Origin;Ethnic Population;evidence base;Exhibits;experience;Exposure to;Health;Hispanic;Immune;improved;Incidence;Individual;Inequity;Inflammatory;Intervention;Knowledge;Latinx;Link;Literature;Long-Term Effects;Longterm Follow-up;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;marginalized population;Measures;Mediating;Mediator;Metabolic;Modeling;mortality risk;National Health and Nutrition Examination Survey;neighborhood association;Neighborhoods;Nested Case-Control Study;Not Hispanic or Latino;novel;Outcome;Participant;Pathway interactions;perceived stress;Phenotype;Physiological;Prevention strategy;Process;prospective;Prospective cohort;Public Health;Public Policy;Publishing;Race;racial difference;racial population;Racial Segregation;residential segregation;response;Risk;Risk Factors;Sampling;Sampling Studies;social factors;Socioeconomic Status;socioeconomics;Stress;stressor;structural determinants;Structural Racism;System;Testing;Time;Tissues;triple-negative invasive breast carcinoma;tumor;United States;White Women;Woman;Women's cohort;Women's Health

PROJECT_TITLE: Impact of Allostatic Load and Neighborhood Contextual Factors on Breast Cancer in the Women's Health Initiative

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(91)S]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Osteoporosis;Racial and Ethnic Minority Health Research

PI_NAMEs: ZHAO, LAN-JUAN  (contact)

PROJECT_TERMS: African American population;Age;aged;Archives;Area;Asian population;biobank;biomedical informatics;Biopsy;Blood;bone;bone cell;Bone Density;Bone Marrow;Bone Marrow Aspiration;bone marrow mesenchymal stem cell;Caucasians;Cell Separation;Clinic;Clinical;clinical examination;Clinical Research;Collaborations;Consent;Consent Forms;DNA;Dual-Energy X-Ray Absorptiometry;electronic recording system;Eligibility Determination;Endocrinology;Enrollment;Epidemiology;epidemiology study;Ethnic Origin;experience;Fasting;Feces;Finite Element Analysis;Fracture;Funding;Genomics;Goals;Health system;Height;Hematology;Hip Fractures;Hip region structure;Hispanic;Hospitals;Human;human subject;ilium;Informed Consent;Intake;Latino;Louisiana;Measures;Medical;Medical center;Medical Oncology;medical schools;men;monocyte;multiple omics;musculoskeletal imaging;nutrition;Orthopedic Surgery;Osteoblasts;Osteoporosis;osteoporosis with pathological fracture;Patients;peripheral blood;Pilot Projects;Plasma;Population;Preparation;Procedures;programs;Questionnaires;Radiology Specialty;Recontacts;Recording of previous events;Records;recruit;Research;Resources;sample collection;Sampling;Scanning;Services;sex;Side;Specimen;stool sample;System;Trabecular Bone Score;United States National Institutes of Health;Universities;Urine;Vertebral column;Weight;willingness;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Microbiome;Networking and Information Technology R&D (NITRD);Osteoporosis

PI_NAMEs: WANG, YU-PING  (contact)

PROJECT_TERMS: Achievement;bacteriome;Bioinformatics;Biological;Biometry;Cell Communication;Cell Lineage;Cells;Clinical;Collaborations;comparative;Complex;Complex Analysis;Computer software;Data;data acquisition;Data Analyses;data imputation;data integration;data management;data quality;data sharing;Database Management Systems;Development;Disease;disorder risk;DNA;epigenomics;Etiology;Experimental Designs;Fostering;Funding;gene regulatory network;Genes;Goals;gut microbiome;Human;Human Genome;improved;Individual;innovation;Intuition;Link;Maintenance;Measures;member;Messenger RNA;metabolomics;Metagenomics;Methodology;Methods;Methylation;MicroRNAs;Molecular;Monitor;multilevel analysis;Multiomic Data;multiple omics;novel;novel strategies;Osteoporosis;Pathway interactions;Pattern;Productivity;programs;Publications;Quality Control;Research Design;Research Personnel;Resources;Retrieval;Risk;risk variant;Safety;Sample Size;Services;single-cell RNA sequencing;Special needs;System;Testing;transcriptomics;United States National Institutes of Health;Variant;Vertebral column;Visualization;website development;Work

PROJECT_TITLE: Biostatistics and Bioinformatics Core


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Substance Misuse

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Driving under the influence (DUI) of alcohol remains one of the most frequently repeated offenses, with over one-third of offenders being charged with a second DUI offense within five years. Our research suggests that offenders’ awareness of risks associated alcohol use is diminished, particularly in the intoxicated state, when decisions are made to drive. The proposed research aims to reduce recidivism in offenders using experiential feedback and mindfulness-based approaches to enhance their risk awareness during states of intoxication that pose risk for DUI.

PI_NAMEs: FILLMORE, MARK T (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: Acute;Address;Alcohol consumption;alcohol effect;alcohol response;Alcoholic Intoxication;Alcohols;Automobile Driving;Awareness;Basic Science;Behavior;Behavioral;behavioral impairment;Behavioral Mechanisms;binge drinking;Blood alcohol level measurement;breath alcohol measurement;Characteristics;Charge;Coupled;Decision Making;Dedications;Disinhibition;Dose;drinking;driving behavior;driving under influence;Economics;Education;efficacy testing;Expectancy;Feedback;hazardous drinking;Impairment;improved;Impulsivity;Individual;Injury;innovation;Intervention;Intoxication;Investigation;Laboratories;Laboratory Research;Laboratory Study;Mindfulness Training;motivational enhancement therapy;novel therapeutic intervention;offender;Outcome;Pattern;Perception;Pharmaceutical Preparations;prevent;Prevention;Prevention program;programs;Public Health;Publishing;Reaction;recidivism;reduced alcohol use;Reporting;Research;Resources;response;Risk;risk perception;Risk Taking;Role;Self-control as a personality trait;sobriety;Structure;success;Testing;Time;Training;trait impulsivity;treatment program;United States

PROJECT_TITLE: Impaired Risk Awareness during Intoxication in Recidivist DUI Offenders

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Aging;Clinical Research;Genetics;Human Genome;Microbiome;Osteoporosis;Women's Health Research

PI_NAMEs: SHEN, HUI  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Age;Aging;Animals;Bacteria;Bayesian Analysis;Bioinformatics;Biological Assay;Biological Markers;Biomechanics;Blood;bone;Bone Density;bone loss;bone mass;bone metabolism;bone quality;Bone structure;bone turnover;Cell Lineage;Clinical;clinical predictors;cohort;Computer Analysis;Crohn's disease;Data;data archive;Deterioration;Diabetes Mellitus;Disease;Dissection;epigenome;Estrogens;ethnic difference;Ethnic Origin;Exhibits;Feces;Finite Element Analysis;Genes;Genetic;Genetic Determinism;genetic variant;Genome;genome wide association study;Genomics;Germ-Free;Goals;Gonadal Steroid Hormones;gut bacteria;gut metagenome;gut microbiome;gut microbiota;Heritability;Hip region structure;Human;human disease;Human Genome;in vivo;insight;Intervention;Lactobacillus reuteri;Louisiana;Mendelian randomization;Metabolic Bone Diseases;metabolome;metagenome;Metagenomics;microbial;microbial signature;microbiota;Modeling;Molecular;mouse model;multiple omics;Mus;normal microbiota;novel;Obesity;old mice;Oral;Osteoblasts;Osteoclasts;Osteoporosis;osteoporosis with pathological fracture;Osteoporotic;Outcome;Ovariectomy;Pathway interactions;Patients;Persons;Phenotype;Physiology;Pilot Projects;prevent;Probiotics;Property;recruit;Research;Rest;Rheumatoid Arthritis;Risk;Role;sample archive;Sampling;Serum;sex;Sex Differences;Solid;Taxonomy;Testing;Trabecular Bone Score;trait;transcriptome;Trauma

PROJECT_TITLE: Studying Human Gut Microbiome for Osteoporosis Risk


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Substance Misuse

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Project Narrative: Gender minority (GM; transgender and gender non-conforming) individuals experience disproportionately high rates of hazardous drinking and alcohol use disorder (AUD) and are an NIH-designated disparity population (NOT-MD-19-001). Despite marked disparities and unique alcohol risk factors, there are no evidence-based alcohol interventions for this population. This study will conduct mixed-methods formative research with an established multi-site longitudinal GM cohort to develop and assess the feasibility of the first culturally-adapted psychosocial treatment intervention for GMs with AUD.

PI_NAMEs: KIDD, JEREMY D (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Academy;addiction;Adult;Affect;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol risk;alcohol use disorder;Alcohols;Area;arm;Award;Behavioral Model;binge drinking;Biometry;Birth;career;Caring;Child;Clinical;Clinical Investigator;Clinical Treatment;Clinical Trials;cohort;coping;Cultural Sensitivity;Data;Data Analyses;Discrimination;Disparity;Disparity population;Distress;Divorce;drinking;Drug usage;Drug Use Disorder;Effectiveness;efficacy trial;Ensure;Epidemiology;evidence base;experience;Family;feasibility trial;Friends;Fright;Gender;Gender Identity;gender minority;gender minority group;gender nonconforming;gender transition;General Population;Goals;Grant;hazardous drinking;Health;health disparity;Heavy Drinking;Heterosexuals;Hormonal;improved;Individual;innovation;Interpersonal Relations;interpersonal therapy;Intervention;Interview;Life Experience;Longitudinal cohort;maltreatment;Manuals;marginalized population;Mediating;Mediation;Medicine;member;Mentorship;Methodology;Methods;Minority Groups;motivational enhancement therapy;neglect;Operative Surgical Procedures;Patients;peer;Persons;Physicians;Population;Population Intervention;Prevalence;Prevention;Process;psychologic;psychological distress;psychosocial;Psychotherapy;Qualitative Research;Randomized;Reporting;Research;Research Personnel;resilience;Risk Factors;Role;Scientist;sex;sex assigned;Sex Differences;Sex Discrimination;Sexual and Gender Minorities;Site;social stigma;Social support;Stigmatization;Structure;Substance Use Disorder;substance use treatment;Therapeutic Studies;Training;transgender;treatment program;treatment research;treatment strategy;United States National Institutes of Health;Violence;Writing

PROJECT_TITLE: Improving Alcohol Use Disorder Treatment for Gender Minority Populations

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA(03)-3]


PROJECT_TERMS: Age;age effect;Aging;Area;Biological;Biological Factors;Biological Process;Biopsy;bone;Bone Density;bone health;Bone Marrow;Bone Marrow Aspiration;bone marrow mesenchymal stem cell;bone metabolism;bone quality;Bone Resorption;bone strength;Bone Tissue;Cell Communication;Cell Lineage;cell type;Cells;Classification;Clinical;Collaborations;Complex;Data;Deterioration;Development;Disease;Dissection;Dual-Energy X-Ray Absorptiometry;epigenomics;ethnic difference;Ethnic Origin;Etiology;Finite Element Analysis;fracture risk;gene regulatory network;Genes;Genetic;Genetic Markers;Genome;Goals;gut metagenome;gut microbiome;gut microbiota;Heterogeneity;Human;Human Genome;in vivo;Individual;Inflammation;innovation;Intervention;Joints;Life Style;Louisiana;Macrophage;Measures;Medical History;Metabolic Bone Diseases;metabolome;methylome;Molecular;monocyte;multiple omics;novel;nutrition;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;osteoporotic bone;Outcome;Patient Recruitments;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Pilot Projects;Plasma;Predisposition;Productivity;Recording of previous events;recruit;Research;Resources;Risk;Risk Factors;Sampling;sex;single cell sequencing;single-cell RNA sequencing;Solid;Testing;Time;Trabecular Bone Score;transcriptome;transcriptomics;Weight;whole genome;X-Ray Computed Tomography

PROJECT_TITLE: Single Cell Dissection of Osteo-blasto/clasto-genic Lineage Cells for Osteoporosis


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Boulder

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Colorado’s booming STEM economy requires a prepared biomedical workforce, and numerous career and professional school opportunities in biomedical research and health sciences provide excellent career paths for the diverse Rocky Mountain community. The Bridges to the Biosciences Research Training Program provides a new pathway to a baccalaureate degree in the life sciences for transfer students from Front Range Community College to the University of Colorado Boulder. The training program will promote scientific research opportunities not previously available and will fully engage B2B trainees in scientific education, research, and professional development to increase persistence and retention in biomedical fields.

PI_NAMEs: CARON, MARTHA ;CRAVEN, DEBORAH ;FOSTER, STEPHANIE LYNN;HOKE, CHERYL ;NISWANDER, LEE A. (contact);PEDEN, ERIN A.;YEUNG, FAN

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Admission activity;Agreement;Articulation;Associate Degree;Bachelor's Degree;Biological Sciences;biomedical profession;Biomedical Research;Biotechnology;bridge to the baccalaureate;career;Career Choice;college;Colorado;Communities;community college;County;Credentialing;Degree program;Discipline;Education;Eligibility Determination;Employment;Ensure;Faculty;faculty mentor;Generations;Geography;Goals;Growth;Hispanic;Human;Institution;interest;Latinx;Mission;Pathway interactions;peer;Population;Preparation;programs;recruit;Research;Research Training;Rewards;role model;Schools;Science;Scientific Inquiry;Self Efficacy;skills;STEM career;STEM field;Students;success;System;Time;Training;Training Programs;transfer student;Underrepresented Minority;underrepresented minority student;United States;Universities;university student

PROJECT_TITLE: Bridges to the Baccalaureate Research Training Program at University of Colorado Boulder

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PITTSBURGH

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative We will examine the effect of cerebrovascular plasticity in the aerobic exercise intervention leading to improvement in cognition and how these changes affect brain structural and functional changes. Dose-response effects of exercise on cerebrovascular outcomes will also be investigated. The results from this study have scientific and clinical implications and could help transform public health recommendations of physical activity and exercise for influencing cognitive and brain outcomes in older adults. It could establish more effective preventive and therapeutic strategies to reduce the burden of AD/ADRD.

PI_NAMEs: KIM, TAE  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;adherence rate;Adult;Aerobic Exercise;Affect;age related;Age Years;Aging;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;arterial stiffness;biological sex;Blood flow;Blood Vessels;Brain;brain health;Brain region;brain volume;Cardiac;Cardiovascular system;cerebral atrophy;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular health;Cerebrovascular system;Cerebrum;Clinical;Cognition;Cognitive;Cognitive aging;cognitive enhancement;cognitive function;cognitive performance;cohort;cost effective;Data;Data Analyses;dementia risk;Deterioration;Diabetes Mellitus;dosage;Dose;Exercise;exercise intervention;Functional Magnetic Resonance Imaging;Funding;gray matter;Growth;Health Status;Heterogeneity;Hippocampus;Hypertension;Impaired cognition;improved;interest;Intervention;Intervention Trial;Knowledge;late life;light intensity;Link;Long-Term Effects;Measures;Mediating;men;Methods;Mission;Neurocognition;older adult;Outcome;Participant;peer;Phase;Physical activity;Physical Exercise;post intervention;pre-clinical;prevent;Preventive;Public Health;Public Policy;Pulsatile Flow;Randomized;randomized, clinical trials;Recommendation;recruit;Research;response;Risk;risk mitigation;Risk Reduction;Role;Sample Size;Sampling;sex;Statistical Models;Stretching;Structure;tau Proteins;Temporal Lobe;Testing;Therapeutic;Time;Training;Underrepresented Minority;United States National Institutes of Health;vascular cognitive impairment and dementia;Vascular remodeling;white matter;Woman;Work

PROJECT_TITLE: Examining a dose-dependent exercise intervention on cerebrovascular plasticity in late adulthood

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


PI_NAMEs: ZHAO, QI  (contact)

PROJECT_TERMS: Acceleration;Affect;African American population;Aging;Amino Acids;Bile Acids;Biological;Biological Assay;Biological Markers;Biological Process;biomarker discovery;Biometry;bone;Bone Density;bone health;bone quality;bone turnover;caucasian American;Cells;Cessation of life;Chemicals;clinical translation;cohort;Cyclophosphamide;Data;data archive;design;Deterioration;Diagnosis;diagnostic tool;Direct Costs;disability;Disease;disease phenotype;disorder risk;Dual-Energy X-Ray Absorptiometry;Elderly;epigenome;epigenomics;ethnic difference;Ethnic Origin;Etiology;Fatty Acids;Finite Element Analysis;Fracture;fracture risk;Genetic;Genome;genome wide association study;Glutamic Acid;Goals;gut microbiome;gut microbiota;Heritability;hip bone;Human;Human Genome;improved;In Vitro;in vivo;Individual;innovation;insight;Investigation;Knowledge;Lauric Acids;Link;lipidomics;Lipids;Louisiana;Mediator;Mendelian randomization;Metabolic;Metabolic Bone Diseases;Metabolic Pathway;metabolome;metabolomics;Methods;Molecular;Molecular Structure;Molecular Weight;Morphology;mouse model;multiple omics;novel;novel marker;old mice;osteoblast differentiation;Osteoblasts;Osteocalcin;Osteoclasts;Osteoporosis;osteoporosis with pathological fracture;Participant;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Phenotype;Pilot Projects;Population;Predictive Value;Prevention;Prognosis;Proteome;Quality of life;recruit;Regulation;Research;Risk;Risk Factors;sample archive;Sample Size;screening;sex;Taurine;therapeutic target;Threonine;Time;tool;Trabecular Bone Score;trait;transcriptome;Translational Research;Trauma;Validation;Variant;Volatile Fatty Acids

PROJECT_TITLE: Comprehensive Metabolomics Study of Osteoporosis


ADMINISTERING_IC: AI

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Pediatric;Prevention;Rural Health;Social Determinants of Health;Vaccine Related

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: Project Narrative Lack of adherence with the U.S. recommended immunization schedule leads to increased vaccine preventable disease risk in young children. In this study, we will quantify national and state trends in and factors associated with four novel measures of early childhood immunization services quality: (1) vaccine timeliness, (2) immunization schedule adherence, (3) undervaccination due to parental vaccine hesitancy, and (4) undervaccination due to other access barriers. We will also examine rural-urban differences in immunization services quality to determine which strategies may be most effective for achieving health equity in early childhood vaccination coverage in the U.S.

PI_NAMEs: NEWCOMER, SOPHIA RAFF (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: access restrictions;Achievement;Address;Adherence;Advisory Committees;Affect;Age;Algorithms;Area;Binomial Model;Birth;Cessation of life;Child;Childhood;Communicable Diseases;Complex;contextual factors;COVID-19 pandemic effects;Data;Data Sources;Disease;Disease Outbreaks;disorder control;disorder risk;Disparity;Dose;early childhood;Equity;experience;Goals;health care availability;health equity;health goals;Immunization;Immunization Schedule;improved;Intervention;Link;Measles;Measures;Methods;Modeling;Modification;novel;Parents;Pattern;Pertussis;Population;population based;Prevalence;prevent;Public Health;public health intervention;Recommendation;Records;Risk Factors;Rural;rural area;rurality;Schedule;Series;Services;socioeconomics;standard measure;suburb;Surveillance Methods;Surveys;Testing;Time;trend;United States;urban disparity;Vaccinated;Vaccination;vaccination schedule;vaccine acceptance;vaccine hesitancy;Vaccines;Vulnerable Populations;Work

PROJECT_TITLE: Population-level assessment of early childhood vaccination timeliness, parental vaccine hesitancy, and immunization schedule adherence in the United States, including rural-urban disparities

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PUBLIC HEALTH RELEVANCE Chronic pain is a leading devastating condition that affects more than 100 million Americans annually with symptoms lasting from week to years. Mechanical allodynia (a process regulated by mechanosensory ion channels) is considered one of the most prevalence hallmarks of chronic pain, but little is known about the processes that contribute to its occurrence. We investigate the molecular and cellular pathways that regulate mechanosensory channels and try to identify the specific molecules and proteins that could potentially become drug targets to mitigate pain conditions.

PI_NAMEs: DEL ROSARIO, JOHN SMITH (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Address;Adverse effects;Affect;Afferent Neurons;Agonist;allodynia;American;Animal Model;Behavioral;Biochemical;Biological Assay;Biotinylation;Capsaicin;Cell membrane;Cell surface;Cells;Central Nervous System;Charge;Chemosensitization;Chloroquine;chronic pain;Coupled;Data;Doctor of Philosophy;Drug Targeting;Electrophysiology (science);Endocytosis;Environment;Excision;experience;experimental study;extracellular;Fluorescence;Goals;Health;Human;immunocytochemistry;improved;In Vitro;in vivo;Individual;inhibitor;Injury;Ion Channel;Ligation;Long term disability;MAP2K3 gene;mechanical allodynia;Mechanics;Microscopy;Molecular;Mus;Nerve;Neurons;Nociceptors;novel;optogenetics;Pain;Pathway interactions;Peripheral;Persistent pain;persistent symptom;pharmacologic;Phase;Phosphatidylinositols;Phosphotransferases;Piezo 2 ion channel;Play;Postdoctoral Fellow;Preparation;Prevalence;Process;Proteins;public health relevance;receptor;Regulation;Reporting;response;RNA;Role;Second Messenger Systems;Sensory Process;Skin;Spinal Ganglia;Stimulus;Symptoms;Syndrome;System;Tactile;Techniques;Touch sensation;transcriptome sequencing;Transfection;TRPV1 gene;Vanilloid;Visualization;voltage clamp

PROJECT_TITLE: Homeostatic Regulatory Mechanisms in Nociceptors


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Microbiome;Prevention;Rare Diseases;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Despite strong epidemiological evidence indicating alcohol as a risk factor for oral cancer, the mechanisms of its carcinogenicity remain unclear. A specific role of alcohol's metabolite acetaldehyde is emerging in the carcinogenic process at this site, based on a connection between oral ethanol metabolism and levels of acetaldehyde in the mouth, leading to modifications of DNA and ultimately translating into mutations. Combining cutting edge multi-omic approaches we are dissecting the key steps in this process to provide a systematic assembly of biomarkers, directly relevant to human health, to be used to identify susceptibility, and to develop strategies for early detection and prevention.

PI_NAMEs: BALBO, SILVIA  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Acetaldehyde;adduct;Adult;Alcohol consumption;alcohol exposure;Alcoholic beverage heavy drinker;Alcohols;Aldehydes;Biological Markers;Blood;cancer risk;cancer site;carcinogenicity;Carcinogens;Cell Line;Cells;Chemicals;Chronic;Consumption;COVID-19 impact;Data Analyses;data mining;Development;DNA;DNA Adducts;DNA Damage;DNA Modification Process;DNA Sequence Alteration;Dose;drinking;Drug Metabolic Detoxication;Early Diagnosis;Enzymes;Epidemiology;Esophagus;Ethanol;Ethanol Metabolism;Exposure to;Face;Fanconi's Anemia;Genetic;genome-wide;genotoxicity;Goals;Head and Neck Cancer;Health;healthy volunteer;Heterozygote;high risk;Homozygote;Human;Impairment;Individual;Induced Mutation;Knowledge;liquid chromatography mass spectrometry;Liver;malignant mouth neoplasm;Malignant Neoplasms;Measurement;Measures;Metabolic;Metabolism;Methods;microbiome;microbiome composition;Modeling;Modification;Mouth Neoplasms;Mucous Membrane;multiple omics;Mutagenesis;Mutation;Oral;oral carcinogenesis;Oral cavity;oral microbial community;oral microbiome;Participant;Patient Recruitments;Patients;Play;Predisposition;Prevention;Prevention strategy;Process;Rattus;Reaction;repaired;Reporting;Risk;Risk Factors;Role;Sales;Saliva;Sampling;Site;Solid;Stomach;Techniques;Testing;Time;tool;Translating;trend;Tumor Tissue;Work

PROJECT_TITLE: Dissecting the role of acetaldehyde in oral carcinogenesis

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Cystic Fibrosis;Lung;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE With the rapid emergence of highly effective modulator therapies for cystic fibrosis lung disease, new outcome measures are urgently needed to critically assess mild lung disease and to carefully assess the effectiveness of such medications. Perfluorinated gas MRI has the potential to fulfill this critical need in CF and other airways diseases by providing combined functional and structural assessment of ventilation abnormalities. Further development of this outcome measure may ensure the efficient development of novel therapeutics to provide timely access for patients in need.

PI_NAMEs: GORALSKI, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: 17 year old;absorption;Acute;Address;Adolescent;Adopted;Adult;advanced disease;Adverse effects;Age;Air;Airway Disease;airway inflammation;Alveolar;Anesthetics;Asthma;Biochemical;Biological;Biological Markers;Biometry;Biostatistical Methods;Blood;Blood capillaries;Breathing;Bronchiectasis;chest computed tomography;Child;Childhood;children with cystic fibrosis;Chronic;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Investigator;clinical outcome measures;Clinical Research;Clinical Trials;cohort;Contrast Media;cost;Cross-Sectional Studies;Cystic Fibrosis;cystic fibrosis patients;Data;Development;Disease;Early Diagnosis;effectiveness evaluation;Ensure;Feasibility Studies;Fluorine;Functional disorder;Gases;Goals;Grant;healthy volunteer;High Resolution Computed Tomography;Image;indexing;Infant;informal learning;Inhalation;innovation;Ionizing radiation;Life;Longitudinal Studies;Lung;Lung Diseases;lung imaging;Lung Transplantation;Magnetic Resonance Imaging;Measurement;Measures;Medical;Medical Imaging;Methods;Mucous body substance;Nitrogen;novel therapeutics;Outcome;Outcome Measure;Oxygen;Patients;pediatric patients;Performance;Pharmaceutical Preparations;Physiological;Population;preservation;prevent;Protons;public health relevance;Pulmonary Cystic Fibrosis;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;Quality of life;Questionnaires;Radiation exposure;Reporting;Research;Research Design;Research Personnel;Respiratory Failure;Respiratory Tract Infections;Risk;Sedation procedure;Site;Solubility;Spirometry;Structure;Symptoms;Techniques;Technology;Testing;Time;Training;training opportunity;treatment response;triplet state;ventilation;Vulnerable Populations

PROJECT_TITLE: Quantitation and Spatial Registration of Airways Dysfunction with Dynamic 19F MRI in Cystic Fibrosis

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Prevention;Substance Misuse

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE One of the most challenging sequelae for patients undergoing lumbar spine surgery is chronic post-surgical pain (CPSP) which is associated with poor physical function and long-term opioid use. There is a significant need for effective nonpharmacologic interventions, such as Acceptance and Commitment Therapy, to prevent CPSP and long-term opioid use. Moreover, identifying psychosocial and psychophysical phenotypes associated with treatment efficacy will allow for a cost-effective, precision medicine approach.

PI_NAMEs: MEINTS, SAMANTHA M (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: acceptability and feasibility;Acute;Adherence;care seeking;central pain;Cessation of life;Chronic;chronic pain;chronic pain management;chronic pain patient;Clinical Research;Clinical Trials;common treatment;cost;cost effective;Data;Depressed mood;Development;Diffusion;Dose;Drops;Emotions;Feedback;flexibility;Focus Groups;Foundations;Functional disorder;Goals;implementation strategy;improved;Intervention;Manuals;Medical;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methodology;negative affect;Nervous System;Nociception;Nonpharmacologic Therapy;Operative Surgical Procedures;Opioid;opioid misuse;opioid therapy;opioid use;opioid use disorder;Orthopedic Surgery;overdose risk;Pain;pain catastrophizing;Pain intensity;Pain interference;Participant;Patients;Phenotype;Physical Function;Population;Postoperative Pain;precision medicine;prescription opioid;prevent;Prevention;Prevention therapy;Protocols documentation;psychologic;Psychophysics;psychosocial;Quality of life;Questionnaires;randomized, clinical trials;Randomized, Controlled Trials;Reporting;response;Risk Reduction;Severities;Spine pain;Spine surgery;Therapeutic Intervention;therapy development;Thinking;tool;Training;treatment as usual;Treatment Efficacy;Treatment Side Effects

PROJECT_TITLE: PREventing Pain after Surgery: A feasibility and acceptability study of Acceptance and Commitment Therapy for the prevention of chronic post surgical pain (PREPS)

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Sleep Research;Social Determinants of Health;Telehealth

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

ORG_STATE: MI

PHR: PROJECT NARRATIVE Cognitive behavioral therapy for insomnia can now be delivered digitally (dCBT-I), enabling millions of individuals access to the recommended first-line therapy for insomnia; however, overall rates of treatment completion and adherence are less than 50%, with larger disparities in those with low socioeconomic status. The proposed project will test enhancing dCBT-I with telehealth coaching to reduce disparities and improve overall engagement to digital insomnia treatment.

PI_NAMEs: CHENG, PHILIP  (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Address;Adherence;Adult;Affect;Aftercare;Automobile Driving;Behavior Therapy;Behavioral;behavioral health;built environment;cardiovascular disorder risk;Certification;Cognitive Therapy;comparison control;comparison intervention;Computers;Control Groups;Data;design;Devices;digital;digital delivery;digital health;digital intervention;Disease;Disparity;disparity reduction;Education;Effectiveness;Ensure;Environment;Equity;evidence base;Feedback;Goals;Health;health disparity;health disparity populations;health literacy;Healthcare;high risk population;improved;Individual;innovation;Internet;Intervention;Interview;Learning;Life;low health literacy;low socioeconomic status;Medical;medical specialties;Mental Depression;Modality;Monitor;Morbidity - disease rate;mortality;Motivation;Myocardial Infarction;Nurses;Patient Compliance;patient stratification;Patients;personalized medicine;Persons;PhenX Toolkit;Population;Provider;Qualitative Methods;Recommendation;Research;response;Risk;Sampling;scaffold;secondary analysis;Self Efficacy;Services;Sleep;Sleeplessness;social culture;socioeconomic disparity;Socioeconomic Status;Specialist;Stress and Coping;Stroke;Structure;Suicide;Tablets;Technology;telehealth;Telephone;Testing;Training;treatment adherence;treatment disparity;treatment risk;underserved community;Work

PROJECT_TITLE: Enhancing digital CBT-I to improve adherence and reduce disparities

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Headaches;Migraine;Neurosciences;Pain Research

ORG_CITY: PORTLAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Ocular pain and photophobia are debilitating conditions associated with migraine and dry eye disease (DED) and are also commonly experienced by patients following refractive surgery. The mechanisms underlying these pain conditions and photophobia are poorly understood but are likely to involve interactions between the pain-sensing neurons and light-sensing cells of the eye, as well as components of the immune system. The proposed research aims to elucidate the molecular mechanisms and neural pathways involved and to identify potential therapeutic targets.

PI_NAMEs: AICHER, SUE A (contact);MORGANS, CATHERINE W

PROJECT_TERMS: afferent nerve;Afferent Neurons;Anatomy;antagonist;Automobile Driving;Behavior;Behavioral;Cd68;Cells;Confocal Microscopy;Cornea;corneal epithelium;density;Development;Dry Eye Syndromes;Dura Mater;Electron Microscopy;Electrophysiology (science);experience;experimental study;Eye;Eye Development;eye dryness;FDA approved;Feedback;Female;Gap Junctions;Homeostasis;Hypersensitivity;Immune;immune cell infiltrate;Immune system;immunocytochemistry;Infiltration;Investigation;Iris;Light;Measures;Mediating;melanopsin;Methods;Migraine;Modeling;Molecular;Nerve;nerve injury;Neural Pathways;Neuroanatomy;neurochemistry;Neuroglia;Neurons;Nociceptors;non-opioid analgesic;novel;ocular pain;Operative Surgical Procedures;Pain;pain model;pain sensation;Pathway interactions;Patients;Persistent pain;pharmacologic;Pharmacological Treatment;Phenotype;Photophobia;Physiological;Population;protein expression;Proteins;Proteomics;Pupil light reflex;Reflex action;Regulation;Research;response;Retina;Rodent Model;Sensory;Stimulus;Structure of trigeminal ganglion;Surgical Models;System;targeted agent;Testing;therapeutic development;therapeutic target;tissue injury;Tissues;Touch sensation;Trigeminal nerve structure;Trigeminal System;TRP channel;Up-Regulation

PROJECT_TITLE: Mechanisms of Pain and Photophobia in Migraine and Dry Eye


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Rare Diseases

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Basement membranes are subject to mechanical damage throughout the life of the organism. Improper repair or maintenance can lead to basement membrane diseases, including Alport Syndrome, Goodpasture Syndrome, asthma, and diabetes. Upon completing this proposal, I will have identified components required for basement membrane repair and elucidated a mechanism for detecting and repairing damaged basement membranes.

PI_NAMEs: STRICKER, AUBRIE  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Address;Adult;Appearance;Asthma;Basement membrane;Biological Assay;Biology;Cell Differentiation process;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen Type IV;crosslink;Data;Diabetes Mellitus;Disease;Disease Progression;Drosophila genus;Electron Microscopy;Enterocytes;Enteroendocrine Cell;Enzymes;Epithelial Cells;epithelial repair;Epithelium;Extracellular Matrix;Fat Body;feeding;fly;gastrointestinal epithelium;Goodpasture Syndrome;Hereditary nephritis;Image;Immunity;inhibitor;insight;Intestines;Ion Channel;Irritants;Knock-in;Knock-out;Life;Maintenance;Mammals;Matrix Metalloproteinases;Mechanical Stress;Mechanics;Metabolism;Midgut;Morphology;Muscle;mutant;Organism;Peristalsis;peroxidasin;Phenotype;Population;precursor cell;Process;Proteins;Regulation;repair model;repaired;Reporting;Reproducibility;Resistance;response;Role;Shapes;Signal Transduction;Sodium Dextran Sulfate;Source;Stains;stem cells;Stretching;Time;Tissues;transmission process;Visualization;Work

PROJECT_TITLE: Basement membrane repair dynamics in the Drosophila midgut

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Nearly all adults after middle age display clonal hematopoiesis, a phenomenon in which mutated cells are overrepresented in the peripheral blood, increasing risk for hematological malignancy and cardiac disease. While low-frequency mutant clones are present in most adults by middle age, our understanding of the factors that promote eventual clonal expansion remains limited. The objective of this study is to determine whether mutant hematopoietic stem cells always expand with enough time and underlying mutation burden, with the ultimate goal of enhancing healthy aging.

PI_NAMEs: KAPADIA, CHIRAAG DEEPAK (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Ablation;Address;Adult;Affect;Age;age effect;aged;Aging;Behavior;Blood;Blood Cells;blood fractionation;Bone Marrow;Cardiovascular Diseases;Cells;Clonal Expansion;Clonality;Code;conditional knockout;Development;DNA Damage;driver mutation;Elderly;Environmental Risk Factor;exome sequencing;experience;experimental study;fitness;Frequencies;Future;Genes;Goals;Health;healthy aging;Heart Diseases;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;Hematopoietic stem cells;Hematopoietic System;Human;imprint;Individual;Knock-out;Knockout Mice;Laboratory mice;leukemia;Life;life span;Literature;Longevity;Lung Diseases;Mammals;Measures;MGMT gene;middle age;Modeling;mortality;mouse model;MSH2 gene;Mus;Mutagens;mutant;Mutate;Mutation;Non-Insulin-Dependent Diabetes Mellitus;normal aging;novel;old mice;older adult;Older Population;peripheral blood;permissiveness;Predisposition;Prevalence;Probability;repaired;Reporting;Risk;Role;Somatic Mutation;targeted sequencing;temozolomide;Time;Transplantation;Wild Type Mouse;Work

PROJECT_TITLE: The impact of increased mutation burden on promoting clonal hematopoiesis


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: IRVINE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Understanding the complexity of the development of Alzheimer’s disease (AD) and developing and testing effective therapeutics and interventions requires the generation of animal models that faithfully recapitulate the disease. We have spent five years creating the individual components that we will now combine to produce mice that develop relevant aspects of AD. Furthermore, we will carry out deep phenotyping of these mice across their lifespans and align their pathologies and gene expression profiles with human signatures. All mice and data will be made freely available to all investigators, in academia and industry alike, so that the global research field can use these resources to develop and test therapeutics and ultimately combat AD.

PI_NAMEs: GREEN, KIM ;LAFERLA, FRANK M (contact);TENNER, ANDREA JOAN

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Academia;Affect;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid Beta A4 Precursor Protein;Amyloid beta-Protein;Animal Model;Animals;Apolipoprotein E;apolipoprotein E-4;ATAC-seq;Award;base;Behavioral;Biochemical;Biochemistry;Bioinformatics;Biological Markers;biomarker validation;Brain;Brain imaging;California;Cell Nucleus;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cognitive testing;combat;Communities;Data;data management;data modeling;Data Set;Databases;Deposition;design;Development;Diet;Disease;disease model;Disease Progression;disorder subtype;economic impact;effective therapy;efficacious treatment;Electrophysiology (science);Ensure;environmental stressor;Evaluation;forging;Funding;Gene Expression;Gene Expression Profile;gene replacement;Generations;Genes;Genetic;Genetic Risk;Genome;genome wide association study;Goals;Histology;Human;human disease;human model;Image;imaging modality;improved;Individual;Industry;Infrastructure;insight;International;Intervention;Investigation;Knowledge Portal;Late Onset Alzheimer Disease;life span;lipidomics;Liquid substance;Medical;member;metabolome;metabolomics;Methods;microbiome;model organism;Modeling;mouse model;Mouse Strains;Mus;Mutation;Names;neuroimaging;neurovascular;Nomenclature;novel;open source;Outcome;Pathology;Pathway interactions;Persons;Phase;Phenocopy;Phenotype;Physiology;Plasma;Population;programs;Proteomics;Protocols documentation;Reproducibility;Research;Research Personnel;Resources;response;risk variant;Rodent;Sampling;screening;Series;single-cell RNA sequencing;Societies;socioeconomics;Synapses;tau Proteins;Technology;Testing;The Jackson Laboratory;Therapeutic;therapeutic evaluation;therapeutically effective;Tissues;transcriptome sequencing;transcriptomics;ultra high resolution;United States National Institutes of Health;Universities;Validation;Variant;web site;Work

PROJECT_TITLE: UC Irvine MODEL-AD


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: DAVIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative  This project will continue to advance a cognitive test battery for use as a set of outcome measures for clinical trials in intellectual and developmental disabilities (IDD), covering domains such as processing speed, memory, cognitive flexibility, attention and language. The research will improve measurement sensitivity of the NIH Toolbox Cognitive Battery (NIHTB-CB) for lower functioning individuals, expand the scope of the battery to include early numerical and conceptual reasoning, and it will detail the developmental trajectories of these domains of function in children and youth with IDD. Finally, the ability of the NIHTB-CB to detect improvement related to treatment will be evaluated in a controlled trial of a medication known to improve attention and behavior in IDD.

PI_NAMEs: HESSL, DAVID R (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Adaptive Behaviors;Adolescent;Affect;Age;Animal Model;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Basic Science;Behavior;behavioral phenotyping;Child;clinical outcome measures;Clinical Trials;Cognition;Cognitive;cognitive change;cognitive testing;comparative;Concept Formation;Consensus;Crystallization;Data;Development;Disease;Double-Blind Method;Down's Syndrome;Episodic memory;Evaluation;Executive Dysfunction;executive function;feasibility testing;flexibility;Floor;Fragile X Syndrome;Goals;Growth;Human;improved;Individual;Infant;Intellectual functioning disability;interest;Intervention;intervention effect;Knowledge;Language;Language Disorders;Liquid substance;maladaptive behavior;mathematical ability;Measurement;Measures;Memory;mental age;Natural History;Neurobiology;Observational Study;Outcome;Outcome Measure;Patients;Performance;Persons;Pharmaceutical Preparations;Phenotype;Placebo Control;Placebo Effect;Placebos;Population;population based;preclinical study;Predisposition;primary outcome;processing speed;Property;Psychometrics;Randomized;Reading;Recommendation;Research;Research Personnel;Ritalin;Sampling;Severities;Short-Term Memory;Solid;Standardization;Stimulant;Subgroup;Syndrome;Testing;Toddler;tool;translational pipeline;treatment response;United States National Institutes of Health;Validation;Vocabulary;Work;Youth

PROJECT_TITLE: A Cognitive Test Battery for Intellectual Disabilities

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: LAFERLA, FRANK M (contact)

PROJECT_TERMS: Accountability;Alzheimer's Disease;Alzheimer's disease model;Animal Model;Award;Bioinformatics;Blood Vessels;Collaborations;Communication;Communities;Data;data management;data sharing;Development;disease model;Ensure;Equilibrium;experience;Feedback;functional genomics;Generations;Goals;Grant;Human Resources;improved;Indiana;innovation;International;Intervention;Knowledge;Knowledge Portal;Laboratories;Late Onset Alzheimer Disease;Leadership;meetings;member;Memory impairment;Mentors;Methods;model development;Modeling;mouse model;Mus;National Institute on Aging;Nervous System Disorder;neuroimaging;novel;operation;outreach;Phenotype;phenotypic data;Play;Prevention;Program Research Project Grants;programs;Protocols documentation;Recording of previous events;Recurrence;Reporting;Research;Research Personnel;Scientist;Services;success;Synapses;Technology;Testing;The Jackson Laboratory;Therapeutic;therapeutic candidate;Training;United States National Institutes of Health;Universities;Variant;web site;Work

PROJECT_TITLE: Admin/Coordination Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: MORTAZAVI, SEYED ALI (contact)

PROJECT_TERMS: Affect;Alternative Splicing;Alzheimer's disease model;ATAC-seq;Automobile Driving;Bioinformatics;Biological Assay;Brain;California;Cell Nucleus;cell type;Cells;Chromatin;Data;data management;Dedications;Deposition;design;Development;differential expression;Disease;disease model;Disease Progression;experimental study;Female;functional genomics;Gene Expression;Gene Expression Profiling;Genes;Genetic;genome wide association study;Global Change;Hippocampus;Human;human data;Human Resources;interactive tool;interest;Knowledge;Libraries;male;Maps;Measurement;Measures;Messenger RNA;metabolomics;microbiome;Microglia;MicroRNAs;model development;Modeling;mouse model;mRNA sequencing;multiple omics;Mus;novel;Phenotype;Play;posttranscriptional;predictive modeling;Preparation;Process;Production;Proteomics;Protocols documentation;Regulatory Element;Reproducibility;Resources;risk variant;RNA;Robotics;Role;Running;sequencing platform;single cell ATAC-seq;single nucleus RNA-sequencing;Source;Split-Pool Ligation Transcriptome sequencing;Synapses;Techniques;Technology;Time;Tissues;transcriptome sequencing;transcriptomics;Translations;Universities;Untranslated RNA;Variant;Work;XCL1 gene

PROJECT_TITLE: Functional Genomics and Bioinformatics Data management Core


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Brain Disorders;Estrogen;HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: SPELMAN COLLEGE

ORG_STATE: GA

PHR: Project Narrative Despite effective HIV viral control and longer life expectancies due to the success of combined Antiretroviral Therapy (ART), persons living with HIV continue to suffer from neurological complications including Post- traumatic stress disorder (PTSD) and HIV-associated Neurocognitive Disorders (HAND). These complications are predicted to accelerate as patients age and understanding of how a loss of estrogen in the aging population of women living with HIV and PTSD is needed. We will characterize estrogen signaling as a potential endogenous targeted therapeutic avenue to the current antiretroviral arsenal to reduced neuroinflammation, in the aging population of females living with HAND and PTSD.

PI_NAMEs: WILLIAMS, KIMBERLY S. (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acceleration;Address;Affect;Age;aged;Aging;aging population;antagonist;Anti-Inflammatory Agents;Anti-Retroviral Agents;Antibodies;Antioxidants;antiretroviral therapy;Astrocytes;Automobile Driving;Autopsy;Award;Binding;Biological;Biometry;Biotechnology;brain tissue;Calcium;career;career development;clinical diagnosis;Clinical Trials;Coculture Techniques;Collecting Cell;college;comorbidity;Computer software;Conditioned Culture Media;Coupled;Cytometry;Data;data submission;Development;Diagnosis;Disease;Disease Progression;ESR1 gene;Estradiol;Estrogen Receptors;Estrogen Replacement Therapy;Estrogens;experience;Exposure to;Female;Flow Cytometry;Future;Gender;Generations;Goals;GTP-Binding Proteins;Historically Black Colleges and Universities;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human;human induced pluripotent stem cells;human pluripotent stem cell;imaging software;In Vitro;Induced Neurons;induced pluripotent stem cell;Inflammation;Inflammatory;Institution;Knowledge;Lead;Learning;Life;Life Expectancy;Macrophage;Macrophage Activation;Mass Spectrum Analysis;Measures;Mediating;Membrane;men;Menopause;Mentors;Microglia;Modeling;monocyte;Morphology;Nervous System Disorder;neuroAIDS;Neurocognitive;Neurocognitive Deficit;neuroinflammation;Neurologic;Neurons;Neuropathogenesis;neuroprotection;neurotoxicity;Neurotoxins;novel;novel therapeutic intervention;Nuclear Receptors;Pathogenesis;Patients;Persons;Phenotype;Post-Traumatic Stress Disorders;Postmenopause;Premenopause;Principal Investigator;Process;Production;Property;Proteins;psychiatric comorbidity;Quantitative Reverse Transcriptase PCR;Rattus;RBM5 gene;receptor;Receptor Activation;receptor expression;Recording of previous events;Regulation;Reporting;Research;Research Personnel;Role;Science;Signal Pathway;Signal Transduction;skill acquisition;skills;success;synergism;System;targeted treatment;Techniques;Testing;therapeutic target;TNF gene;Training;training opportunity;translational research program;Viral;Western Blotting;Woman;women versus men

PROJECT_TITLE: Estrogen regulation of age and PTSD-associated changes in macrophage-induced neuroinflammation during HIV infection.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: STARK, CRAIG E (contact)

PROJECT_TERMS: 3-Dimensional;Age;age group;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer’s disease biomarker;Animal Model;base;Bioinformatics;Biological Markers;biomarker development;biomarker identification;biomarker signature;Blood Vessels;Brain;Brain region;Cellularity;Cerebrovascular system;Clinical;clinical diagnosis;clinically relevant;Collaborations;Communities;Complex;computerized data processing;Data;data management;Data Set;Development;Diagnosis;Diet;Diffusion;Dimensions;Disease;disease model;Educational workshop;efficacy evaluation;Environmental Risk Factor;Evaluation;Exhibits;functional genomics;Functional Magnetic Resonance Imaging;Genetic;Genomics;Goals;Human;human disease;human model;Image;imaging approach;imaging modality;Individual;innovation;insight;interest;International;Knowledge Portal;Label;Lead;Link;Literature;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Mainstreaming;Maps;Measures;Metabolic;microbiome;model development;Modeling;Monitor;mouse model;Mouse Strains;multimodality;Multiomic Data;multiple omics;Mus;Nature;Neurobiology;neuroimaging;neuroimaging marker;neurovascular;novel;Onset of illness;Paint;Pathology;Perfusion;Phenotype;Physiological;Postdoctoral Fellow;predictive marker;Predisposition;programs;Reproducibility;Research;Research Personnel;Rest;RNA;Rodent Model;Scanning;sex;Sex Differences;spectroscopic imaging;Standardization;Structure;Students;symposium;Techniques;Tissues;Translating;treatment response

PROJECT_TITLE: Neuroimaging and Vascular Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: GREEN, KIM  (contact)

PROJECT_TERMS: 3xTg-AD mouse;Acceleration;Affect;Age;aged;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid Beta A4 Precursor Protein;Amyloid beta-Protein;analysis pipeline;Animal Model;apolipoprotein E-4;assisted reproduction;Award;base;Behavior;Behavioral;Biological Markers;Brain;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;cognitive testing;cohort;Communities;Data;Data Set;density;Deposition;design;Development;dietary control;disease model;disorder subtype;Electrophysiology (science);Foundations;Funding;Gene Expression;Gene Expression Profiling;gene replacement;Generations;Genetic;genetic variant;Genetic Variation;Genome;genome wide association study;Genomics;Goals;Human;human model;human tissue;Image;International;Intervention;Investigation;Knock-in;Knock-in Mouse;Knowledge;Knowledge Portal;Late Onset Alzheimer Disease;life span;Literature;Medicine;metabolome;metabolomics;microbiome;model development;Modeling;mouse model;Mouse Strains;Mus;Names;neuroimaging;Nomenclature;novel;open data;Pathology;Phase;Phenocopy;Phenotype;Physiology;Process;programs;Proteomics;Research;Research Personnel;Resources;response;Risk;risk variant;screening;Series;single-cell RNA sequencing;Synapses;tau Proteins;Testing;Therapeutic;Therapeutic Intervention;Tissues;transcriptomics;TREM2 gene;ultra high resolution;Variant;web site;western diet

PROJECT_TITLE: Disease Model Development and Phenotyping Project


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Lung;Sleep Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Millions of Americans suffer from high blood pressure, diabetes, strokes and motor vehicle accidents due to ineffective treatment of obstructive sleep apnea (OSA). Our preliminary data suggest that physiological causes of OSA such as easy arousability or unstable breathing control may influence effectiveness of OSA’s most common treatment, continuous positive airway pressure (CPAP). The NICE-PAP study will examine how the physiologic traits that cause OSA in each individual impact CPAP effectiveness and can lead to personalized OSA treatments that improve patient lives.

PI_NAMEs: ZINCHUK, ANDREY  (contact)

PROJECT_TERMS: Accounting;Acetazolamide;Address;Adherence;Adult;Affect;Age;American;Anatomy;Apnea;Arousal;Atrial Fibrillation;Automobile Driving;Biological;Biometry;Breathing;career development;Catheters;clinical application;clinical epidemiology;Clinical Pathways;Clinical Research;Clinical Trials Design;cohort;common treatment;Compensation;Continuous Positive Airway Pressure;Critical Care;Data;Data Set;design;Development Plans;Diabetes Mellitus;Diagnosis;Drowsiness;Effectiveness;Engineering;Environment;Epidemiology;epidemiology study;Equipment;Exhibits;Expectancy;experience;externship;Future;Goals;Growth;Heart failure;Hour;Hypertension;hypnotic;Impairment;improved;Individual;ineffective therapies;Infrastructure;Institution;Internal Medicine;Knowledge;Laboratories;Link;Lung;Measurement;Measures;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Modification;Morbidity - disease rate;mortality;Myocardial Infarction;novel;novel strategies;Obstructive Sleep Apnea;Outcome;Oxygen;Pathogenesis;Patient Care;patient oriented;patient oriented research;Patient-Focused Outcomes;Patients;personalized care;personalized medicine;Pharyngeal structure;pharynx muscle;Physicians;Physiological;Physiology;Polysomnography;poor sleep;positive airway pressure;Predisposition;pressure;prevent;programs;prospective;Prospective cohort;psychologic;Psychological Factors;Psychosocial Factor;Pulmonology;Quality of life;randomized trial;randomized, clinical trials;remote monitoring;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Residual state;Resources;response;Risk;Role;Science;Scientist;Self Efficacy;sex;skills;Sleep;Sleep Apnea Syndromes;sleep position;sleep quality;Sleeplessness;social;social factors;Social support;Stroke;success;symptomatic improvement;Symptoms;Techniques;tool;Training;Training Activity;Training Programs;trait;Translating;treatment adherence;vehicular accident;Work

PROJECT_TITLE: Novel physiologiC prEdictors of Positive Airway Pressure effectiveness: NICE-PAP study.


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

PI_NAMEs: HOUGH, CATHERINE LEE (contact)

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Active Learning;career;career development;Clinical;Clinical Competence;Clinical Research;Communication;Communities;community engagement;Competence;Consultations;design;Development;Development Plans;Educational Curriculum;Enrollment;expectation;experience;Faculty;Foundations;Funding;Goals;Grant;Grant Review;Institution;K-Series Research Career Programs;Laboratories;Leadership;Manuscripts;Mentors;Mentorship;Oregon;Outcome;Patients;peer networks;programs;Qualitative Methods;recruit;Research;research and development;Scholars Program;skills;Technology;Time;Training;Training Programs;Translating;Translational Research;translational scientist;Universities;Writing

PROJECT_TITLE: Institutional Career Development Core


NIH_SPENDING_CATS: Genetics

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE: The abscission checkpoint is a cell cycle checkpoint that arrests cytokinetic abscission to ensure the upstream events of mitosis are completed properly before finally dividing. This proposal will integrate new molecular signaling pathways that contribute to maintenance of the abscission checkpoint as well as characterize cellular programs that promote faithful abscission during an abscission arrest. In the long term, our research may enable new treatments to so that we are better able to diagnose and treat diseases when this checkpoint fails.

PI_NAMEs: WENZEL, DAWN  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Autophagocytosis;Biological Assay;cancer cell;Cell Cycle Checkpoint;Cell Proliferation;Cells;Chromosomal Breaks;Chromosome Segregation;Coupled;daughter cell;Development;Diagnosis;Disease;DNA;DNA biosynthesis;DNA Damage;Ensure;Event;Excision;glucose metabolism;innovation;insight;interdisciplinary approach;Link;Maintenance;Malignant Neoplasms;Metabolic;micronucleus;Mitosis;Mitotic;Molecular;novel;Nuclear Pore;Pathway interactions;physical separation;Post-Translational Protein Processing;premature;programs;Proteins;recruit;Regulation;Research;Signal Pathway;Signal Transduction;Structure;Therapeutic;Work

PROJECT_TITLE: Ins and Outs of Abscission Checkpoint Signaling: Molecular Mechanisms Safeguarding Abscission

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Title: Next-generation Mass Spectrometry Technologies for Integrated Structural Proteomics Project Narrative: Knowledge linking proteoform composition to protein structure is critical for our understanding of biological functions in normal and diseased organisms, thus playing a central role in drug development. How proteoforms combine to form this very complex machinery has been a central goal in biomedical research and a host of structural biology and mass spectrometry methods have made great progress, but many complexes remain refractory to such technologies, and their proteoform compliment unknown. Here, we propose to develop a suite of new mass spectrometry strategies capable of simultaneously analyzing protein complex sequence and structure with the ability to capture structure and composition information from small amounts of unlabeled protein, present within complex mixtures that remain difficult or impossible to analyze using classical structural biology probes.

PI_NAMEs: RUOTOLO, BRANDON T (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Amino Acid Sequence;Area;Biological;Biological Process;Biomedical Research;Cell Physiology;Chemicals;Chemistry;Complex;Complex Mixtures;Coupled;Cryoelectron Microscopy;Data;data quality;Data Set;Databases;Derivation procedure;Detergents;Development;Disease;Dissociation;drug development;Electrons;Fingerprint;Free Radicals;Funding;gene product;Goals;high throughput analysis;human disease;improved;innovation;ion mobility;Ions;Knowledge;Label;Lasers;Link;Macromolecular Complexes;Mass Spectrum Analysis;Measures;Membrane Proteins;Methodology;Methods;Modification;Molecular Conformation;multi-photon;Multiprotein Complexes;next generation;Organism;Peptide Fragments;Peptide Sequence Determination;Periodicity;Phase;Phosphorylation;Play;Population;Post-Translational Protein Processing;Process;Production;protein complex;Protein Dynamics;Protein Fingerprints;protein function;protein structure;Proteins;Proteome;Proteomics;Reagent;recruit;Refractory;Reporting;Resolution;Resources;Roentgen Rays;Role;Sampling;Series;Sodium Chloride;stoichiometry;structural biology;Structure;System;Techniques;Technology;technology platform;three dimensional structure;tool;tool development;Variant;Work

PROJECT_TITLE: Next-generation Mass Spectrometry Technologies for Integrated Structural Proteomics- Renewal

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE: The goal of this training program is to provide trainees from historically underrepresented backgrounds with the research experience and enhanced scientific training needed to be competitive for top-tier biomedical science PhD and MD/PhD programs. We anticipate that our scholars will go on to have highly successful careers in academia and the biotechnology industry. Human health and society-at-large will benefit directly as our training program produces creative, highly trained scientists who understand how to conduct rigorous and reproducible research that addresses current questions in biomedical science.

PI_NAMEs: HERNANDEZ, RYAN D.;NYSTUL, TODD  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Academia;Address;Admission activity;Aptitude;Biological Sciences;Biomedical Research;Biometry;Biotechnology;career;career development;college;Communication;Communities;Creativeness;Development;Development Plans;Doctor of Philosophy;doctoral student;early-career faculty;Education;education planning;education research;Educational Activities;Educational process of instructing;Educational Status;Educational workshop;Environment;Equity;Evaluation;Exercise;expectation;experience;Faculty;Family;Feedback;Foundations;Funding;Goals;graduate school;graduate school preparation;Grant;Health;holistic approach;Human;Individual;Industry;instructor;Internships;Knowledge;Laboratories;Leadership;Learning;lectures;Lived experience;meetings;Mentors;Modernization;Monitor;Motivation;multidisciplinary;Outcome Measure;Personal Growth;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;Problem Solving;Process;professional atmosphere;programs;promote resilience;Reproducibility;Research;resilience;Resources;Review Literature;Science;Scientist;Self Direction;Self Perception;Series;skill acquisition;skills;Societies;Structure;Students;success;supportive environment;Time;tool;Training;Training Programs;undergraduate research;Underrepresented Populations;Universities;Update

PROJECT_TITLE: Post Baccalaureate Research Opportunity To Promote Equity In Learning (PROPEL).

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Narrative:  Alzheimer's disease is a major age-related pathology in the US with an estimated medical cost of $277 billion  in 2018. We hypothesize that mitochondrial calcium exchange pathways contribute to AD progression and that  understanding these signaling pathways will yield new therapeutic approaches.

PI_NAMEs: JADIYA, POOJA  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Abeta clearance;abeta deposition;Ablation;age related;Age related pathologies;Agreement;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Amyloidosis;Autophagocytosis;Brain;Calcium;Calcium Signaling;calcium uniporter;career;Cause of Death;Cell Death;Cell Line;Cell Respiration;Cellular Stress;Clinical;cognitive skill;Coupled;Data;Defect;Development;Disease;Disease Progression;Economic Burden;Event;Exhibits;extracellular;gain of function;Generations;Genes;Genetic;Genetic Models;hyperphosphorylated tau;Impaired cognition;Impairment;Link;Mediating;Medical Care Costs;Memory;Memory Loss;Metabolic;Metabolic dysfunction;misfolded protein;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;Modeling;Molecular;Molecular Weight;Mus;mutant;Mutant Strains Mice;Nerve Degeneration;Neurofibrillary Tangles;neuron loss;Neuronal Dysfunction;Neurons;neuropathology;new therapeutic target;novel therapeutic intervention;overexpression;Oxidative Stress;paralogous gene;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Phase;protein aggregation;Proteins;proteostasis loss;Reactive Oxygen Species;release of sequestered calcium ion into cytoplasm;Reporting;Research;Role;Sampling;scaffold;Senile Plaques;Signal Pathway;Signal Transduction;stoichiometry;Synapses;tau Proteins;Testing;theories;Time;Toxic effect;Training;Transgenic Mice;uptake

PROJECT_TITLE: Mitochondrial calcium uptake in Alzheimer’s disease


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative For a gene to function properly, it must be active in the right place, at the right time and in the right amount. Changes in any of these features can lead to disease. This proposal uses mathematical theory and experiment to understand how information about the appropriate place, time and amount of gene activity is encoded in the genome, to help determine the causes of disease directly from DNA sequence.

PI_NAMEs: DEPACE, ANGELA H (contact);GUNAWARDENA, JEREMY

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Area;Attention;Bacteria;Binding;Binding Sites;Biological Models;biological systems;Biology;Blastoderm;Chromatin;chromatin remodeling;Complex;Data;Development;Differential Equation;Disease;DNA;DNA Methylation;DNA Sequence;DNA-Directed RNA Polymerase;Drosophila genus;Embryo;Energy Metabolism;Energy-Generating Resources;Enhancers;Equilibrium;equilibrium model;Eukaryota;Evolution;experimental study;Funding;Gene Expression;Gene Expression Regulation;Genes;genetic regulatory protein;Genetic Transcription;Genome;Goals;Grain;Graph;interest;Laboratories;Link;Markov Chains;mathematical methods;mathematical model;mathematical theory;Mathematics;Measures;Mediator;Medicine;Messenger RNA;Methods;Modeling;Molecular;mRNA Expression;neglect;Nucleosomes;optogenetics;Organism;Output;Pattern;Phenotype;Physics;Physiology;Positioning Attribute;Post-Translational Protein Processing;Process;Production;Property;Proteins;real-time images;recruit;Regulation;Research;response;Role;Study models;System;theories;Thermodynamics;Time;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: Information Integration and Energy Expenditure in Eukaryotic Gene Regulation

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: NEW YORK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The liquid-liquid phase separation of proteins to create a condensed phase is a fundamental strategy for organizing cellular contents. Improved understanding of how molecular and macromolecular changes influence these condensed compartments could enable the creation of a new platform to control protein function as well as provide insight into the dysregulation of phase separation in disease (neurodegeneration and cancer). The proposed research program plans to develop (1) orthogonal phase separated compartments with a range of molecular and materials properties and (2) methods to gain insight into how molecular parameters influence partitioning and diffusion of small and large molecules in the condensed phase.

PI_NAMEs: OBERMEYER, ALLIE C (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Address;Amino Acid Sequence;Binding;Cataract;Cations;Cell Physiology;Cells;Chemicals;Development;Diffusion;Disease;Electrostatics;Engineering;Environment;Enzymes;Eukaryotic Cell;Gene Expression;Goals;imaging modality;improved;In Vitro;in vivo;Individual;insight;intermolecular interaction;Liquid substance;macromolecule;Malignant Neoplasms;Membrane;Metabolic Control;Metabolic Pathway;Methods;Molecular;molecular scale;Nerve Degeneration;Organelles;Phase;Phase Transition;Physical condensation;Physical Function;physical property;Play;programs;Prokaryotic Cells;Property;protein function;protein structure;Proteins;Research;Signal Transduction;synthetic biology

PROJECT_TITLE: Development of functional synthetic biomolecular condensates.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]