NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Estrogen;Menopause;Mental Health;Mental Illness;Neurosciences;Psychosis;Serious Mental Illness;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative This grant seeks to investigate the effects of estradiol on perimenopausal-onset anhedonia and psychosis and reward-related brain functioning measured by simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR). Results of this project will increase our understanding of anhedonia and psychosis during the menopause transition and will have the potential to deliver validated molecular imaging targets to use in future mechanistic clinical trials of novel treatments for perimenopausal-onset anhedonia and psychosis.

PI_NAMEs: DICHTER, GABRIEL S (contact);LALUSH, DAVID S;SCHILLER, CRYSTAL EDLER

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Address;Anhedonia;Behavior;Biological;biomarker identification;Brain;Clinical Trials;Corpus striatum structure;Data;Depressive disorder;design;Diagnostic;Dimensions;Distress;Dopamine;Dopamine Antagonists;dopamine D3 receptor;dopamine system;Double-Blind Method;Endocrine;Ensure;Estradiol;Estrogen Therapy;Etiology;experimental group;Functional disorder;Functional impairment;Functional Magnetic Resonance Imaging;Future;Grant;Impairment;improved;Incidence;Magnetic Resonance Imaging;Measures;Mental Depression;Mental disorders;mesolimbic system;Modeling;Molecular;molecular imaging;Mood Disorders;Moods;Morbidity - disease rate;mortality;neural;neuromechanism;neurotransmission;novel;Participant;Pathogenesis;Perimenopause;Phase;Placebo Control;placebo group;Placebos;Positron-Emission Tomography;pre-clinical;Predisposition;Psychoses;psychotic;Raclopride;Randomized;recruit;reproductive;Research;response;reward anticipation;reward circuitry;reward processing;Rewards;Risk;Sampling;Severities;Stratification;Symptoms;targeted imaging;treatment response;Withdrawal;Woman;Women's prevalence;Work

PROJECT_TITLE: Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE B cells produce the antibodies that help us control infections and are the primary mechanism though which vaccines work. Although we understand well the general biology of B cells, the rules determining how the immune system chooses what targets to make antibodies too, and how the durability of these antibodies is controlled remain unclear. Better understanding of these rules will be essential to designing more potent vaccines against variable pathogens such as influenza, HIV, HCV, and SARS-CoV2.

PI_NAMEs: VICTORA, GABRIEL D (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 2019-nCoV;Affinity;Antibodies;Antibody Affinity;Antibody Response;Antibody titer measurement;Antibody-mediated protection;Antibody-Producing Cells;Antigens;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Biology;Bone Marrow;Cell Maintenance;Cellular biology;Chronic;Clone Cells;Color;COVID-19 pandemic;cross reactivity;Data;design;Effectiveness;Epitopes;Funding;Goals;Grant;Hepatitis C virus;HIV;Home;Immune response;Immune system;Immunity;Immunization;imprint;improved;Infection;Infection Control;Influenza;Influenza Hemagglutinin;Influenza vaccination;Investigation;Laboratories;Logic;Maps;Measures;Memory;Memory B-Lymphocyte;Methods;Modeling;Molecular;Mutate;Mutation;neutralizing antibody;novel;Parabiosis;pathogen;Phase;plasma cell differentiation;Plasma Cells;Plasmablast;Play;Population;Property;protective efficacy;Publications;Reaction;Research;response;Role;SARS-CoV-2 spike protein;seasonal influenza;Serum;Shapes;Source;Specificity;stem;Structure;Structure of germinal center of lymph node;System;Testing;Time;tool;universal vaccine;Vaccination;vaccination strategy;Vaccines;Viral;Virus;Virus Diseases;Waxes;Work

PROJECT_TITLE: Clonal Dynamics of the antibody response

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Substance Misuse

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE As Africa's most populous country, Nigeria is one of six nations facing the threats of high HIV burden, low combination antiretroviral treatment (ART) coverage, and slow decline in new HIV infections. While ART programs have turned HIV into a chronic condition, morbidity from HIV-associated NCDs is becoming more common as HIV-infected individuals live longer, encumbering an already troubled and undercapacitated health system and emphasizing the need to develop clinical trial research capacity to generate evidence to tackle the burden of HIV and NCDs in Nigeria. In response to this need, the Vanderbilt-Nigeria Building Research Capacity in HIV/Non-communicable Diseases (NCDs) (`V-BRCH') program harnesses the longstanding and highly successful research partnership between Aminu Kano Teaching Hospital and the Vanderbilt Institute for Global Health to establish a research and training platform that will create a cohort of highly skilled Nigerian investigators with the capacity to lead independent clinical trials research focused on the intersection of HIV and NCDs.

PI_NAMEs: ALIYU, MUKTAR HASSAN (contact);SANI, MAHMOUD UMAR;WESTER, C. WILLIAM

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Academic Medical Centers;Africa South of the Sahara;Area;Atmosphere;career development;clinical investigation;Clinical Trials;Collaborations;Conduct Clinical Trials;Country;Disease;Educational Curriculum;Educational workshop;Epidemiology;Faculty;Foundations;Funding;Grant;HIV;Institution;institutional capacity;Learning;Master of Public Health;Master of Science;meetings;member;Mentors;Methodology;Nigeria;Nigerian;peer;Peer Group;Physicians;Pilot Projects;programs;Public Health Education;Research;research and development;Research Ethics;Research Institute;Research Personnel;Research Project Grants;Scientist;Site;skill acquisition;Staff Development;Sustainable Development;Teaching Hospitals;Training;Training Activity;Training Programs;United States;Universities;Work;Writing

PROJECT_TITLE: Vanderbilt-Nigeria Building Research Capacity in HIV and Non-communicable Diseases (NCDs) (V-BRCH)


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: MORGANTOWN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE This project aims to test the hypothesis that bi-directional interaction between tumor microenvironment and region-specific macrophages plays a role in tumor progression thru regulation of hypoxia and acidosis. In vivo mapping of tumor hypoxia using innovative magnetic resonance technology in mice deficient in specific macrophage populations or lacking hypoxia-regulated macrophage functions in a mouse model of breast cancer may provide new insight into a macrophage/tumor microenvironment axis that suppresses the efficacy of clinically-relevant anti-cancer therapies.

PI_NAMEs: EUBANK, TIMOTHY D;KHRAMTSOV, VALERY V (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Acidity;Acidosis;Acute;acute infection;Address;angiogenesis;Angiogenic Factor;Animal Cancer Model;Anti-Bacterial Agents;Anti-Inflammatory Agents;Area;Award;Blood Vessels;Bone Marrow;Breast Cancer Model;Breast Cancer Patient;cancer therapy;chemokine receptor;chemotherapy;Chemotherapy and/or radiation;Chronic;clinical efficacy;clinically relevant;cohort;Development;Dichloromethylene Diphosphonate;Disparate;docetaxel;Effectiveness;Electron Spin Resonance Spectroscopy;Elements;Endothelium;Event;extracellular;Functional disorder;Homeostasis;Hypoxia;Image;Image Guided Biopsy;imaging modality;Imaging technology;Immunologics;improved;in vivo;in vivo monitoring;innovation;insight;Knockout Mice;Label;Liposomes;Location;Macrophage;Magnetic Resonance;Magnetic Resonance Imaging;Mammary Neoplasms;Maps;Methodology;Modality;monocyte;mouse model;Mus;normoxia;Occupations;Oxygen;parent grant;Particulate;Perfusion;Play;polyoma middle tumor antigen;Population;Prognosis;Progress Reports;Protein Tyrosine Kinase;Receptor Protein-Tyrosine Kinases;recruit;Regulation;repaired;Reporting;residence;response;Role;Sampling;Scanning;Shapes;Site;Solid Neoplasm;Techniques;Technology;Testing;Therapeutic;Time;Tissues;transcription factor;Treatment outcome;tumor;tumor hypoxia;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Tissue;Tumor-associated macrophages;United States National Institutes of Health;Vascular Endothelial Growth Factors;Work;wound healing

PROJECT_TITLE: In vivo monitoring of tumor microenvironment regulation for macrophages


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Wound Healing and Care

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Abstract Pseudomonas aeruginosa (P. aeruginosa) is versatile opportunistic pathogen that can cause devastating persistent infections; P. aeruginosa successfully colonizes a hyper-inflammatory environment of the wound and can persist for months or years even with aggressive therapy. The overall objective of this study is to develop bacteriophages that can be used alone or in combination with traditional antibiotics to eradicate these infections. This research will directly benefit patients with chronic wound infections, the numbers of which are substantially increasing in our health care system.

PI_NAMEs: WOZNIAK, DANIEL J (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;Adjuvant;Affect;aggressive therapy;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotic Therapy;antibiotic tolerance;Antibiotics;antimicrobial resistant infection;Bacteria;Bacterial Infections;bactericide;Bacteriophages;Biological Models;Biology;burn wound;Caring;Cells;Cessation of life;Characteristics;chronic infection;chronic wound;commensal microbes;Complex;cytotoxicity;Defense Mechanisms;Ecology;Ecosystem;effective therapy;Elements;ESKAPE pathogens;Etiology;Evolution;Exudate;Family suidae;Foundations;Future;Healthcare Systems;Human;Immune response;Immunosuppression;In Vitro;in vitro activity;in vivo;in vivo evaluation;Infection;infectious disease treatment;Inflammatory;inflammatory milieu;Injury;Knowledge;Liquid substance;Medical Care Costs;Metabolic;microbial;Microbial Biofilms;microbiome;microbiota;Morbidity - disease rate;mortality;Multi-Drug Resistance;multi-drug resistant pathogen;multidrug-resistant Pseudomonas aeruginosa;multiple omics;Mus;non-healing wounds;opportunistic pathogen;pathogen;Pathogenicity;Patients;Persons;preclinical study;Predisposition;prevent;programs;Property;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Research;research clinical testing;Resistance;response;Skin;standard of care;Staphylococcus aureus;System;Therapeutic;therapy development;Time;Toxic effect;Translating;translation to humans;Variant;wound;wound care;wound environment;Wound Infection;Wound models

PROJECT_TITLE: The impact of bacteriophage therapy on wound infection dynamics

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Pain Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Here we seek to understand how sensory perception is calibrated during development. Understanding the pathways governing the peripheral sensory nervous system’s appropriate assembly will inform our treatment strategies for the millions of individuals suffering from pain and movement disorders.

PI_NAMEs: ZUNDER, ELI  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Ablation;Address;Afferent Neurons;Analgesics;Atlases;attenuation;Behavioral Assay;behavioral phenotyping;Brain region;Brain-Derived Neurotrophic Factor;brain-derived neurotrophic factor precursor;Calibration;Cell Death;Cell Differentiation process;Cell Lineage;Cell Survival;cell type;Cells;combinatorial;Compensation;Coupled;critical period;Cytometry;Dancing;Data;design;Development;dimension reduction;disease model;Dissection;Embryo;Environment;experience;experimental study;Family;Family member;Female;Fluorescence Microscopy;ganglion cell;Goals;high dimensionality;Hour;In Vitro;in vivo;Individual;interest;Logic;male;Maps;Measurement;Measures;Methods;Modality;Modeling;Molecular;Monitor;mouse genetics;Movement Disorders;Mus;Muscle;Mutation;Nerve Growth Factor Receptors;Nerve Growth Factors;nerve stem cell;nerve supply;Nervous System;Nervous System control;nervous system development;neural;Neural Crest;Neuronal Differentiation;neuronal survival;Neurons;neurotrophic factor;Neurotrophin 3;new technology;NGFR Protein;Nociception;Nociceptors;Organ;Outcome;Pain Disorder;Pain Threshold;Pathway interactions;Perception;Peripheral;Peripheral Nervous System;Phenotype;Play;Population;Positioning Attribute;postnatal;postnatal development;programs;Proprioception;Proprioceptor;Publishing;Rationalization;receptor;Receptor Protein-Tyrosine Kinases;Research;response;Retina;Role;Sensory;Series;Sex Differences;Signal Pathway;Signal Transduction;Signaling Molecule;single cell analysis;Skin;small molecule inhibitor;Smell Perception;somatosensory;Specific qualifier value;Spinal Cord;Spinal Ganglia;stem cells;Taste Perception;technology platform;Testing;Time;time use;Tissues;TNF gene;TNFRSF1A gene;treatment strategy;Tumor Necrosis Factor Receptor;Vision;Work

PROJECT_TITLE: Deciphering Trophic Signaling Programs Governing Peripheral Sensory Nervous System Development

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE This is a career mentoring award to support the PI, Dr. Renee Heffron of the University of Washington, to mentor the next generation of researchers focused on HIV prevention, oral pre-exposure prophylaxis (PrEP), and novel PrEP products. Additionally, new proposed research will identify best practices to integrate novel PrEP products into existing platforms for oral PrEP delivery.

PI_NAMEs: HEFFRON, RENEE A. (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: Adherence;Africa;African;African American population;African Women;AIDS prevention;Award;Behavioral Sciences;career;Clinical;Clinical Research;Cognitive;Communicable Diseases;Communities;Counseling;Dapivirine;design;Doctor of Philosophy;doctoral student;Dose;Epidemiologist;Epidemiology;Evaluation;experience;experimental study;Faculty;Female;Funding;global health;Grant;HIV;HIV Infections;HIV risk;Home;Hour;implementation research;implementation science;Incidence;informant;Injectable;International;Interview;Kenya;Lesotho;Manuscripts;meetings;Mentors;Methods;mid-career faculty;Modality;next generation;novel;Oral;patient oriented research;Persons;Phase III Clinical Trials;phase III trial;pill;Postdoctoral Fellow;pre-doctoral;pre-exposure prophylaxis;preference;Preparation;Prevention Research;programs;Provider;Qualitative Research;Reproductive Health;Research;Research Assistant;Research Personnel;Safety;Science;Scientist;side effect;skills;social;South Africa;Structure;Tenofovir;theories;Time;Training;Translational Research;Uganda;Underrepresented Populations;United States National Institutes of Health;Universities;uptake;Vaginal Ring;Vision;Washington;Woman;Work;Writing;young woman

PROJECT_TITLE: Mentoring and research to prepare oral PrEP delivery platforms for novel HIV prevention products

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric

ORG_CITY: SAN DIEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Because irritability in late childhood and adolescence predicts mental disorders and poorer functional outcomes across the lifespan, identifying the neural mechanisms of irritability across the transition to adolescence is paramount to intervene before youth irritability problems harden into entrenched psychiatric disorders in later adolescence and adulthood. Our overall goal is to identify reward- and inhibition-related neural pathways that characterize changes in irritability across the transition to adolescence. Our project is significant because it will be a catalyst for a research program to inform precision medicine for irritability.

PI_NAMEs: DOUGHERTY, LEA R;WIGGINS, JILLIAN LEE (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Adolescence;Adolescent;Adult;adverse outcome;Age;Amygdaloid structure;Anger;Anxiety;Behavioral;Biological;Brain;brain based;brain behavior;catalyst;Characteristics;Childhood;Clinical;cognitive development;contextual factors;Corpus striatum structure;Data;Data Set;Development;Diagnostic;Disease;early adolescence;Ethnic Origin;financial incentive;follow-up;Formulation;Frustration;Functional disorder;Functional Magnetic Resonance Imaging;functional outcomes;Future;Goals;Image;innovation;Intervention;Interview;life span;Link;Machine Learning;machine learning method;Measures;Mental Depression;Mental disorders;Modeling;neural;neural circuit;neural correlate;Neural Inhibition;neural network;Neural Pathways;neuromechanism;Neurophysiology - biologic function;neuroregulation;novel;Parents;preadolescence;precision medicine;Prefrontal Cortex;prevent;programs;prospective;Psychopathology;Puberty;Race;recruit;Reporting;Research;response;reward processing;Rewards;Risk;Role;Sampling;sex;Signal Transduction;socioeconomics;Subgroup;Suicide;Techniques;Time;usability;Work;Youth

PROJECT_TITLE: Neural mechanisms of risk for irritability across the transition to adolescence

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: PROVIDENCE PORTLAND MEDICAL CENTER

ORG_STATE: OR

PHR: PROJECT NARRATIVE Pancreatic cancer is largely resistant to immunotherapy, chemotherapy, and radiation therapy, in part due to presence of an immunosuppressive tumor microenvironment that limits adaptive tumor control. This proposal investigates how macrophages responding to damage-associated molecular patterns released from dying cells reinforce the immunosuppressive tumor microenvironment through activation of the inflammasome. A deeper understanding of mechanisms underlying immunosuppression following radiation therapy will allow us to therapeutically target these pathways to achieve durable responses in a larger subset of patients than currently attainable.

PI_NAMEs: MEDLER, TERRY R (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: adaptive immune response;Adjuvant;antagonist;antitumor effect;Antitumor Response;autoinflammatory;Binding;Bioinformatics;Biology;cancer cell;carcinogenesis;career;CASP1 gene;CD8-Positive T-Lymphocytes;cell type;Cells;Cellular Stress;Characteristics;chemotherapy;Chronic;Colitis associated colorectal cancer;combinatorial;Communication;cytotoxic;Cytotoxic Chemotherapy;Data;Data Set;Dendritic Cells;Development;effective therapy;Fellowship;Funding;Gene Expression Profile;Genes;Genetic Transcription;Goals;Heterodimerization;Homeostasis;Homo;IL18 gene;IL1R1 gene;Immune;immune activation;immune checkpoint blockade;immune function;Immune response;Immune system;immunogenic cell death;immunomodulatory therapies;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Infection;Infiltration;Inflammasome;Inflammation;Inflammatory;Innate Immune Response;K22 Award;Knockout Mice;Laboratories;Leukocytes;Ligation;Lymphoid Cell;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;MERTK gene;microbial;Molecular;Mus;Mutation;Myeloid Cells;Natural Immunity;Nature;novel;Outcome;pathogen;Pathology;Pathway interactions;patient subsets;Patients;Pattern;Phagocytes;Phenotype;Postdoctoral Fellow;Program Research Project Grants;programs;radiation response;Radiation therapy;receptor;recruit;release factor;Research;Research Personnel;Resistance;response;Role;sensor;Signal Transduction;skills;Specificity;Squamous cell carcinoma;statistics;T cell response;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;therapeutically effective;Tissues;TNFRSF5 gene;Toll-like receptors;Training;tumor;Tumor Immunity;Tumor-associated macrophages;tumor-immune system interactions;tumorigenesis;Up-Regulation;Wild Type Mouse;Work

PROJECT_TITLE: Contribution of the Inflammasome to Radiation Response in Pancreatic Cancer


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative This application focuses on a family of RNA-binding proteins (ZFP36/TIS11) identified in our screens are able to control “stemness” and differentiation of acute myeloid leukemia (AML) cells. It tests the hypothesis that 3’UTR targeting of key hematopoiesis-regulating mRNAs by the ZFP36/TIS11 family represents a novel posttranscriptional mechanism of stem cell differentiation and leukemic transformation.

PI_NAMEs: AIFANTIS, IANNIS  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: 3' Untranslated Regions;Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Acute Promyelocytic Leukemia;Adult;Affect;Apoptosis;Binding;Binding Proteins;Cell Differentiation process;cell growth;Cell Physiology;Cells;Child;CRISPR screen;CRISPR/Cas technology;Data;Differentiation Therapy;Elements;Enhancers;Epigenetic Process;epigenomic profiling;Family;gain of function;Gene Expression;Genetic Diseases;genome-wide;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Human;Human Genetics;In Vitro;in vivo;Intervention;Laboratories;Length;leukemia;Leukemic Cell;leukemic stem cell;leukemic transformation;Maintenance;Malignant - descriptor;Malignant Neoplasms;Maps;member;Messenger RNA;Modification;monocyte;mRNA Stability;mRNA Transcript Degradation;mRNA Translation;Mus;Myelogenous;Myeloid Leukemia;neoplastic cell;novel;overexpression;paralogous gene;Patients;Pattern;Pharmaceutical Preparations;Poly(A) Tail;Post-Transcriptional Regulation;posttranscriptional;progenitor;Proteins;Regulator Genes;Regulon;RNA;RNA Recognition Motif;RNA Splicing;RNA-Binding Proteins;Role;screening;self-renewal;Shapes;Spliceosomes;stem;stem cell differentiation;stem cells;stemness;Surface Antigens;Survival Rate;targeted treatment;Testing;Transcript;tumor initiation;tumor progression;Undifferentiated;Yin;ZFP36L2 gene;Zinc Fingers

PROJECT_TITLE: mRNA stability and its impact on hematopoiesis and acute leukemia

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative In order to advance our understanding of the nature of biomedical changes associated with Alzheimer’s disease (AD), we will develop a novel, non-invasive, and cost-effective retinal vascular biomarker for early AD risk detection and disease monitoring. An understanding of metrics of retinal tissue oxygenation and their associations with retinal structure and other functional measures in AD patients will provide information valuable for the early detection, management, and monitoring of the disease in the preclinical phase. Outputs from this proposal will be used to identify whether a novel retinal vascular biomarker can be used to characterize distinct cognitive groups and thus identify it as a potential retinal biomarker of early AD risk detection and disease monitoring.

PI_NAMEs: ARTHUR, EDMUND  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Affect;Age;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;Analysis of Covariance;Angiography;arteriole;Biological Markers;Blood capillaries;Blood Vessels;Blood-Retinal Barrier;Brain;Central Nervous System;Cerebrospinal Fluid;Clinical;Cognitive;Cognitive aging;Contrast Sensitivity;Control Groups;cost effective;cost efficient;curative treatments;Data;Dementia;Detection;Development;Diagnostic;Diffuse;Disease;Dropout;early detection biomarkers;Early Diagnosis;Early Intervention;effective therapy;Ganglion Cell Layer;Goals;health assessment;high risk;Human;Impaired cognition;Individual;Ischemia;Linear Regressions;Measures;Methods;mild cognitive impairment;Modeling;Monitor;multimodality;Nature;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurologist;Neurons;novel;Nutrient;older adult;Optical Coherence Tomography;Outcome;Output;Oxygen;Participant;Pathology;Patients;Pericytes;Peripheral;Persons;Phase;Positron-Emission Tomography;pre-clinical;prevent;preventive intervention;Process;Public Health;Reporting;Retina;Retinal Ganglion Cells;retinal nerve fiber layer;retinal neuron;Risk;ROC Curve;screening;Senile Plaques;Sensory;Specificity;Spinal Puncture;Structure;Symptoms;Testing;Thick;tissue oxygenation;venule;Vision;Visual;Width;Work

PROJECT_TITLE: Characterizing Retinal Tissue Oxygenation, Structure, and Function in Alzheimer's Disease


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infertility;Stem Cell Research;Stem Cell Research - Embryonic - Human;Women's Health Research

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: PROJECT NARRATIVE Creation of sperm and egg that contribute to our next generation requires an incredible series of coordinated events, including recombination and synapsis between homologous chromosomes, and two rounds of chromosome segregation. Using mouse and human systems, our lab investigates how these events are coordinated to ensure fertility and avoid genetic disorder.

PI_NAMEs: JORDAN, PHILIP W (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Affect;Aneuploidy;aurora kinase A;Biogenesis;Bispecific Antibody 2B1;Cell Cycle;Cells;Centrioles;Centrosome;Chromosome abnormality;Chromosome Pairing;Chromosome Segregation;Chromosomes;Clinical;conditional knockout;Congenital Abnormality;Data;Development;Diagnosis;DNA biosynthesis;egg;Ensure;Event;Excision;Fertility;Fertilization;Gametogenesis;Genetic Diseases;Genetic Recombination;Germ Cells;Haploidy;Heterozygote;Homologous Gene;Human;Hyperactivity;Infertility;Knockout Mice;Knowledge;Mediating;Meiosis;mental development;Microtubule-Organizing Center;Mitotic;Modeling;Modification;mouse model;Mus;Mutation;next generation;novel;Oocytes;Oogenesis;Phase Transition;Phosphorylation;Phosphotransferases;PLK1 gene;Pregnancy;prevent;Procentriole;Process;Property;Proteins;Regulation;Reporting;Research;Risk;Role;S phase;segregation;Series;sexual dimorphism;Sister Chromatid;sperm cell;Spermatocytes;Spermatogenesis;System;Techniques;Testing;tool;yeast two hybrid system;Yeasts

PROJECT_TITLE: Regulation of microtubule organizing centers during mammalian gametogenesis

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ORG_CITY: Los Alamos

ORG_NAME: TRIAD NATIONAL SECURITY, LLC

ORG_STATE: NM

PHR: Project Narrative Supercomputers will be used to simulate a major antibiotic target (the ribosome) in atomic detail. Atomistic and reduced-model molecular simulations will be used to understand ribosome conformational changes, and effects of antibiotics on these processes. Results will be closely integrated with single molecule data. Testable predictions will be made to guide future experiments.

PI_NAMEs: SANBONMATSU, KARISSA Y (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;aerobic respiration control protein;Affect;Anisotropy;Antibiotic Resistance;Antibiotics;Bacteria;Bacterial Infections;Binding;Calibration;Cessation of life;Complex;computing resources;COVID-19 pandemic;Cryoelectron Microscopy;Data;design;Discrimination;Doxycycline;drug resistant bacteria;Drug Targeting;Dyes;Electrostatics;Equation;Equilibrium;Event;experimental study;Fluorescence Resonance Energy Transfer;Future;Head;High Performance Computing;Hospitals;improved;information processing;kinetic theory;Kinetics;Label;Laboratories;large scale simulation;Length;Ligands;Measurement;mechanical properties;Methods;Modeling;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;molecular scale;Movement;Multiple Bacterial Drug Resistance;mutant;Noise;Pharmaceutical Preparations;Photons;Positioning Attribute;Process;protein complex;Proteins;Resistance;resistance mutation;Resolution;Ribosomes;Sampling;Signal Transduction;simulation;single molecule;single-molecule FRET;statistics;structural biology;Structure;supercomputer;System;Techniques;Testing;Time;Transfer RNA;triplet state

PROJECT_TITLE: Large-scale simulations of ribosomal decoding


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Identification of extranodal extension (ENE) for head and neck cancer in the pretreatment setting would be extremely useful in selecting the optimal treatment strategy for patients. Currently, ENE can only be definitively diagnosed pathologically after surgery, and pretreatment radiographic ENE prediction has proven unreliable for expert diagnosticians. This project uses artificial intelligence to identify ENE pretreatment on Computed Tomography, with the goal of developing a clinically usable tool to help patients with newly diagnosed head and neck cancers and their physicians choose the most effective treatment strategy that minimizes the risk of side effects.

PI_NAMEs: KANN, BENJAMIN HARRIS (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Adjuvant Therapy;Algorithms;Artificial Intelligence;Artificial Intelligence platform;automated segmentation;Biopsy;cancer imaging;capsule;chemoradiation;chemotherapy;Clinic;Clinical;clinical implementation;Clinical Trials;cohort;comparison control;Complex;computerized;cost;Data;Data Set;Decision Making;deep learning;design;Detection;Development;Diagnosis;Disease;disorder control;draining lymph node;effective therapy;Enrollment;Evaluation;Extranodal;Eye;Foundations;Future;Geography;Goals;Head;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Health Care Costs;heuristics;Human;Image;Image Analysis;imaging platform;improved;Infiltration;insight;Institution;interest;Lead;Lymph Node Involvement;lymph nodes;Machine Learning;Malignant Neoplasms;Manuals;Maps;Medical Imaging;Modality;Morbidity - disease rate;Neck Dissection;neural network;neural network architecture;Newly Diagnosed;novel;Operative Surgical Procedures;optimal treatments;Output;Pathologic;Pathology;Pathway interactions;patient stratification;Patients;Pattern;Performance;personalized cancer care;Phase;Phase II Clinical Trials;phase II trial;Physicians;Positioning Attribute;Positron-Emission Tomography;prediction algorithm;Process;Prognostic Factor;prospective;Prospective cohort;prospective test;Radiation;Radiation therapy;radiological imaging;radiologist;radiomics;Research;risk minimization;risk stratification;Scanning;Scientist;side effect;Specificity;success;Testing;therapy development;Time;Tissues;tool;Training;Translating;Treatment outcome;treatment planning;treatment strategy;tumor;usability;Work;X-Ray Computed Tomography

PROJECT_TITLE: Development of an artificial intelligence-driven, imaging-based platform for pretreatment identification of extranodal extension in head and neck cancer

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Genetics;Kidney Disease;Nutrition;Pediatric;Prevention;Urologic Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative The proposed research is relevant to the NIH mission to improve health as it will test the notion that rifampin, a widely used and safe antibiotic, can be repurposed as a safe and effective treatment for idiopathic infantile hypercalcemia, a lifelong disorder associated with elevated levels of blood and urinary calcium and recurrent renal stones. Patients with idiopathic infantile hypercalcemia manifest hypersensitivity to vitamin D due to genetic deficiency of CYP24A1, an enzyme that inactivates vitamin D metabolites. There is no standard treatment for the vitamin D defect in idiopathic infantile hypercalcemia, and the studies that we propose have the potential to normalize vitamin D metabolism in this disorder, thus providing a novel medical treatment for patients with idiopathic infantile hypercalcemia as well as other forms of renal stone disease.

PI_NAMEs: LEVINE, MICHAEL A. (contact);WEBER, DAVID R

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Affect;Alleles;Antibiotics;Biological;Blood;Bone Density;bone health;Bone Mineral Contents;Bone Resorption;bone turnover;C-telopeptide;calcification;Calcitriol;Calcium;calcium absorption;calcium excretion;Caring;Chronic;Clinical Trials;Collagen Type I;COVID-19;CYP3A4 gene;CYP3A5 gene;Data;Defect;design;Diet;Disease;Dose;Dual-Energy X-Ray Absorptiometry;effective therapy;efficacy evaluation;Enrollment;Enzymes;FDA approved;Feedback;Food;Funding;Genes;Genetic;Genetic Polymorphism;Goals;Grant;Health;Heterozygote;Hypercalcemia;hypercalciuria;Hypersensitivity;improved;individualized medicine;Induced Mutation;infancy;Infant;Infantile hypercalcemia;innovation;Intestinal Absorption;Intestines;Kidney;Kidney Calculi;Kidney Failure;Life;Liver;Measures;Medical;Metabolic;Metabolism;Minerals;Mission;Mixed Function Oxygenases;Monitor;Morbidity - disease rate;Mutation;Nephrolithiasis;next generation sequencing;novel;novel strategies;older patient;open label;Oral;Osteogenesis;Outcomes Research;Pathway interactions;Patients;pediatric patients;Pharmaceutical Preparations;Phase;Phenotype;Plasma;prevent;primary outcome;Production;Rare Diseases;rare genetic disorder;recruit;Recurrence;Request for Proposals;Research;Research Project Grants;Resources;response;Rifampin;Role;Safety;Science;Serum;Serum Markers;skeletal;standard care;standard of care;Study Subject;Sun Exposure;Testing;Therapeutic;Trabecular Bone Score;United States National Institutes of Health;urinary;Urine;Variant;Vitamin D;Vitamin D supplementation;Vitamins;Work

PROJECT_TITLE: Repurposing rifampin to reduce elevated levels of blood and urine calcium in patients with inactivating mutations of CYP24A1

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Cardiovascular disease is a progressive condition that typically results in increasingly invasive interventions over the lifetime of the patient. The significance of this proposal is in the ability to provide a patient specific intervention that can be automatically adapted over time. To achieve this goal, several technical innovations will be implemented including partial electrical nerve block of sympathetic cardiac activity and direct norepinephrine (NE) readings to assess cardiac function.

PI_NAMEs: VRABEC, TINA LOUISE (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Abdomen;Acute;Area;Arrhythmia;autonomic nerve;Autonomic Nerve Block;autonomic reflex;Axon;Bilateral;Biosensor;Blood Vessels;Cardiac;Cardiac ablation;Cardiac Myocytes;Cardiovascular Diseases;Catecholamines;Characteristics;Chest;Chronic;clinically relevant;conventional therapy;Coronary heart disease;Data;Decentralization;density;Development;Disease;Down-Regulation;effective therapy;Effectiveness;electric field;Elements;Evaluation;Excision;Feedback;Goals;Heart;Heart Diseases;Heart failure;heart function;Heart Rate;Hyperalgesia;Hyperhidrosis disorder;Implantable Defibrillators;indexing;Individual;innovation;interstitial;Intervention;Investigation;Ischemia;Laboratories;Manuals;Modality;Monitor;Myocardial dysfunction;Nerve;Nerve Block;neuroregulation;Neurotransmitters;Norepinephrine;novel;Operative Surgical Procedures;Outcome;Pathology;Pathway interactions;Patients;Periodicity;Peripheral;Persons;Pharmaceutical Preparations;porcine model;Property;Reaction Time;Recovery;Reflex action;Regulation;response;Rodent Model;Scanning;side effect;Source;Specific qualifier value;Stress;sudden cardiac death;Sympathetic Nerve Block;System;Tachyarrhythmias;technique development;Techniques;Technology;temporal measurement;Therapeutic;Time;Tissues;United States;Ventricular;Work

PROJECT_TITLE: Investigation of Partial Electrical Nerve Block for Autonomic Regulation

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NORMAN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Overall Significance to Public Health (Project Narrative)  The overarching objective of this COBRE application is to establish a new biomedical imaging research center with appropriate infrastructure and research capacity along with a multidisciplinary mentoring team to support the promising research project leaders of junior investigators as they conduct the innovative translational cancer research projects using advanced medical imaging technology. The success of this COBRE will ultimately have a high research and clinical impact lead to a reduced cancer burden both for individual patients and society as a whole.

PI_NAMEs: JO, JAVIER ANTONIO (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Advisory Committees;American Cancer Society;American Indian Tribe;Area;Authorization documentation;Biomedical Engineering;biomedical imaging;Cancer Burden;Cancer Center;cancer imaging;Cancer Patient;Cancer Research Project;cancer risk;cancer therapy;career;Centers of Research Excellence;Clinical;Clinical Data;clinical imaging;Clinical Research;clinically relevant;cohort;Collaborations;college;Communities;Data;data resource;Databases;Death Rate;Dedications;Development;Diagnosis;Early Diagnosis;Economic Burden;Education;Engineering;Ensure;Environment;Equipment;experience;Faculty;Fostering;Funding;Future;Goals;Health;Health Sciences;Healthcare;human subject;Image;image processing;imaging biomarker;imaging facilities;imaging informatics;Imaging Techniques;Imaging technology;improved;in vivo;individual patient;Infrastructure;innovation;Interdisciplinary Study;Investments;Joints;Lead;Leadership;Machine Learning;Malignant Neoplasms;Medical center;Medical Imaging;Mentors;Methods;Molecular;Morphology;multidisciplinary;National Cancer Institute;novel;Oklahoma;overtreatment;personalized medicine;Physicians;Physiology;Pilot Projects;Play;Positioning Attribute;precision medicine;predictive marker;Prognosis;programs;Public Health;Publishing;quantitative imaging;Regulation;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;research study;Research Support;Research Training;Resource Sharing;Resources;risk prediction;Role;Scientist;screening;Screening for cancer;Security;Services;social;Societies;Software Tools;Statistical Data Interpretation;Strategic Planning;success;synergism;technology development;tool;translational cancer research;Translational Research;tumor diagnosis;Universities;Vertebrates;Water

PROJECT_TITLE: Oklahoma Center of Medical Imaging for Translational Cancer Research


NIH_SPENDING_CATS: Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer

PI_NAMEs: ZHENG, BIN  (contact)

PROJECT_TERMS: Advisory Committees;Applications Grants;Atmosphere;Award;Biomedical Engineering;biomedical imaging;Budgets;Cancer Center;career;career development;Career Mobility;Centers of Research Excellence;Clinical;Clinical Data;clinical imaging;Clinical Research;clinical translation;Collaborations;college;Committee Members;Communication;Critiques;data resource;design;Diagnosis;Early Diagnosis;Educational workshop;Engineering;Ensure;Environment;Evaluation;Faculty;Feedback;Financial Activity;Fostering;Funding;Funding Agency;Funding Mechanisms;Goals;Grant;Image Enhancement;improved;Individual;Infrastructure;Institution;K-Series Research Career Programs;Leadership;Learning;Malignant Neoplasms;Maps;Medical center;Medical Imaging;meetings;Mentors;Mission;Modeling;Monitor;Oklahoma;operation;Performance;Phase;Physicians;Pilot Projects;Policies;Process;Productivity;recruit;Regulation;Request for Applications;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Role;Schedule;Scientist;Screening for cancer;Secure;Services;Study Section;success;Surveys;symposium;synergism;technology development;Teleconferences;Training;translational cancer research;Travel;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases

ORG_CITY: DAVIS

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Transcriptional memory is a biological phenomenon first described in yeast genetics studies and now widely seen in other organisms. Using the well-organized herpesvirus mini-chromosome as a tool to replicate the phenotypes and study molecular mechanisms is a very convenient, efficient, and highly cost-effective approach to understand underlining mechanisms of enhancer-promoter regulations. Understand how transcription memory (latent KSHV chromatin) is maintained will help us to understand regulation of herpesvirus latency.

PI_NAMEs: IZUMIYA, YOSHIHIRO  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Affinity Chromatography;Alanine;Alkylation;Amino Acid Sequence;Authorization documentation;Bacterial Artificial Chromosomes;Baculoviruses;Binding;Biochemical;Biological Phenomena;biosafety level 2 facility;cell killing;Cell Line;Cell Lineage;Cells;cellular targeting;CHD4 gene;Chromatin;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;Clinical;Complex;cost effective;Cryoelectron Microscopy;Disease;disease phenotype;DNA;DNA biosynthesis;Docking;ds-DNA;Engineering;Enhancers;Enzymes;Epigenetic Process;Episome;Event;Frequencies;Gene Activation;Genes;Genetic;Genetic Enhancer Element;Genetic study;Genetic Transcription;Genome;Genomic Segment;Genomics;Herpesviridae;Hi-C;Human Herpesvirus 4;Human Herpesvirus 8;infected B cell;Infection;insight;institutional biosafety committee;Laboratories;latency-associated nuclear antigen;latent infection;Life Cycle Stages;Link;Lymphoma;Lytic;lytic gene expression;lytic replication;Maintenance;Malignant Neoplasms;Mammalian Cell;Maps;Mediating;Memory;Metabolic;meter;Modeling;Molecular;mutant;Mutation;Nature;Noise;Nuclear;Organism;Outcome;peptide drug;Peptides;Pharmaceutical Preparations;Phenotype;Play;Population;promoter;protein complex;Proteins;Proteomics;Recombinant DNA;Recombinants;Regulation;Regulatory Element;Resolution;Risk Factors;RNA;RNA Polymerase II;Role;Signal Transduction;Site;Small RNA;stem;Stimulus;Structure;Sulfhydryl Compounds;Surface;Terminal Repeat Sequences;Therapeutic Intervention;tissue culture;Tissues;tool;Trans-Activators;transcription factor;Transcription Initiation Site;transcriptome sequencing;transcriptomics;tumor;tumorigenesis;Untranslated RNA;Viral;Virus Latency;yeast genetics

PROJECT_TITLE: Studies on Epigenetically Active Latent Chromatin Maintenance

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ORG_CITY: Nashville

ORG_DEPT: BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: This MERIT project will clarify circadian mechanisms at molecular levels that were heretofore unreachable. Biological clocks have been found to be crucial for physical and mental health, and knowledge of circadian mechanisms along with the development of therapies to properly phase sleep will allow us to enhance health, performance, and well-being in addition to improving the quality of life for depressed subjects.

PI_NAMEs: JOHNSON, CARL HIRSCHIE (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: alertness;Bacteria;Binding;Biochemical;Biological;Biological Clocks;Biological Models;Biological Process;Biophysics;Chronobiology;circadian;circadian pacemaker;Circadian Rhythms;Clock protein;Codon Nucleotides;Compensation;cost effective;Data;Depressed mood;differential expression;Enzymes;Evaluation;Genetic;Health;Hormones;Human;improved;In Vitro;insight;Knowledge;Mammals;Mental Health;Metabolic;Metabolism;Modeling;Molecular;Molecular Analysis;mutant;Mutation;novel;Organism;Performance;Personal Satisfaction;Phase;physical conditioning;programs;Property;Proteins;Quality of life;reconstitution;recruit;Research Project Grants;Resolution;single molecule;Sleep;Structure;Temperature;Testing;therapy development;Time;Work

PROJECT_TITLE: Circadian Programs in Bacteria

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LIU, HONG  (contact)

PROJECT_TERMS: Address;Algorithmic Software;anti-cancer research;Area;Biomedical Engineering;Cancer Center;Centers of Research Excellence;Characteristics;Cities;Clinical;Clinical Research;Collaborations;Collection;college;Communities;Computer Assisted;Computer software;Computers;Consumption;cost;cost effective;Custom;Data;Dedications;deep learning;design;Development;Devices;digital pathology;Doctor of Philosophy;Educational workshop;Emerging Technologies;Engineering;Equipment;Evaluation Research;experience;flexibility;Fluorescence;Foundations;Funding;Future;Goals;Image;image processing;imaging biomarker;Imaging Device;imaging facilities;imaging informatics;imaging modality;imaging study;Imaging Techniques;Imaging technology;improved;Industry;informatics tool;Infrastructure;innovation;Interdisciplinary Study;interest;Laboratories;Laboratory Research;Leadership;Learning;Learning Module;Libraries;Machine Learning;machine learning model;machine learning prediction;Medical center;Medical Imaging;Medical Informatics;Medicine;meetings;member;Methods;Mission;Multimodal Imaging;new technology;Oklahoma;operation;optical imaging;Outcome;Patients;Phase;Phenotype;Physicians;Pilot Projects;programs;quantitative imaging;radiomics;Reader;Reading;Research;research and development;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Roentgen Rays;Scheme;Series;Services;Software Tools;Solid;Surveys;synergism;System;technology development;Testing;Time;tomography;tool;Training;transfer learning;translational cancer research;Translational Research;tumor;Universities;Work;X-Ray Medical Imaging

PROJECT_TITLE: Medical Imaging Technology Development Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE The proposed research is the necessary first step to building a stronger evidence-base for the use of diuretics as a management strategy for BPD, which are frequently prescribed despite limited evidence for their benefit. This study and the proposed larger clinical trial will answer the current, relevant clinical questions of whether individual patients in the current treatment era derive short-term benefits from diuretic treatment and whether diuretic treatment is safe and effective in the long-term.

PI_NAMEs: HIBBS, ANNA MARIA ;KAPLAN, HEATHER CECILLE (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: absorption;Address;Adrenal Cortex Hormones;adverse outcome;Affect;Age;Alveolar;antenatal;Attitude;Belief;Birth Weight;Bronchopulmonary Dysplasia;Childhood;Chlorides;Chronic;Clinical;clinical practice;Clinical Trials;clinically relevant;cost;Data;design;Diuretics;Dose;Dropout;Edema;Effectiveness;Electrolytes;Eligibility Determination;evidence base;Extremely Low Birth Weight Infant;Functional disorder;Furosemide;Goals;Heterogeneity;improved;Incidence;individual patient;Infant;infant outcome;innovation;interstitial;Kidney;Liquid substance;Lung;Lung Compliance;Lung Diseases;Mechanics;Meta-Analysis;National Heart, Lung, and Blood Institute;Nephrocalcinosis;Osteopenia;ototoxicity;Outcome;Oxygen;Parents;Participant;participant enrollment;Patients;Phase;Placebo Control;Placebos;Pregnancy;premature;Premature Infant;Provider;Randomized;Randomized, Controlled Trials;Research;Resources;respiratory;responders and non-responders;response;Running;Safety;Sample Size;Series;side effect;Sodium;Steroids;Strategic vision;surfactant;symptom management;symptomatic improvement;Therapeutic;treatment effect;trial design;willingness

PROJECT_TITLE: Pragmatic Research on Diuretic Management in Early BPD (PRIMED) Pilot

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(OA)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Although it is widely known that people with opioid use disorder struggle to abstain from opioid use even when receiving evidence-based opioid substitution treatment, the cognitive and neural changes that give rise to reuse risk remain poorly understood. In this project, we use new behavioral, computational, and imaging tools to evaluate the role of a potential modifiable neurocognitive mechanism of reuse risk: unrealistic optimism driving more uncertainty tolerant decision making. Ultimately, our findings have the potential for clear benefits in a clinical setting, providing easily implementable tools to monitor and potentially manage reuse risk, and evaluate clinical status in individual patients.

PI_NAMEs: KONOVA, ANNA BORISOVA (contact)

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: Automobile Driving;Behavioral;behavioral study;behavioral tolerance;Belief;Brain region;Cessation of life;Chronic;Clinical;Clinical assessments;clinically relevant;Cognitive;cognitive task;cohort;Complex;computerized tools;Computing Methodologies;Corpus striatum structure;cost;Data;Data Collection;Decision Making;Decision Theory;design;Diagnosis;Dimensions;disorder risk;driving behavior;Drug usage;Evaluation;Event;evidence base;Exhibits;Feeling;follow-up;Functional Magnetic Resonance Imaging;General Population;Goals;Health;high risk;Human;Imaging Device;improved;Individual;individual patient;Inferior frontal gyrus;Intervention;Investigation;Judgment;Laboratories;Life Expectancy;longitudinal design;Longitudinal Studies;Measures;Mediating;Mediation;Mediator;medication for opioid use disorder;Modeling;Monitor;mortality;Nature;neural;neural circuit;neural patterning;Neurobiology;Neurocognitive;novel;novel therapeutic intervention;Opioid;opioid epidemic;Opioid replacement therapy;opioid use;opioid use disorder;optimism;Outcome;Overdose;patient engagement;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Persons;Pharmaceutical Preparations;Population;Prefrontal Cortex;Probability;Process;Process Measure;prospective;Psychiatry;Psychopathology;Recovery;Relapse;relapse risk;Resolution;Risk;Role;Safety;Sampling;targeted treatment;Testing;theories;Therapeutic Intervention;time use;tool;Translating;Uncertainty;Work

PROJECT_TITLE: Computational psychiatry investigation of the role of unrealistic optimism in opioid use disorder and relapse

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MOORE, KATHLEEN N. (contact)

PROJECT_TERMS: Address;Animal Model;Archives;Awareness;Biological Specimen Banks;Biomedical Engineering;biomedical imaging;Biometry;Biostatistics Core;Cancer Center;cancer diagnosis;Cancer Research Project;Centers of Research Excellence;central database;Certification;Clinical;clinical biomarkers;Clinical Data;clinical imaging;Clinical Research;clinical translation;Collaborations;college;commercialization;Communities;Computer software;cost effectiveness;Cost effectiveness research;Data;Data Analyses;data resource;Databases;design;Development;digital;Educational workshop;Engineering;Ensure;Evaluation Indexes;Experimental Designs;Faculty;Goals;graphical user interface;Health Sciences;Histopathology;human subject;human subject protection;Image;imaging biomarker;imaging study;Imaging technology;informatics infrastructure;Infrastructure;Institutional Review Boards;Joints;Knowledge;Leadership;Learning;Link;Machine Learning;machine learning method;machine learning model;Magnetic Resonance Imaging;Medical center;Medical Imaging;member;Metadata;Methodology;Methods;Modeling;Monitor;Oklahoma;operation;Pathologist;Performance;performance tests;Policies;programs;Prospective Studies;Protocols documentation;Publishing;quantitative imaging;radiological imaging;radiologist;radiomics;Regulation;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Retrospective Studies;Sample Size;Sampling;Sampling Studies;Secure;Services;shared database;Slide;Stains;Statistical Data Interpretation;statistics;Study models;success;Testing;The Cancer Imaging Archive;Training;translational cancer research;Translational Research;Treatment outcome;United States National Institutes of Health;Universities;Validation;Vertebrates;welfare;Writing

PROJECT_TITLE: Clinical Imaging and Data Resources Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Precision Medicine;Rare Diseases;Rehabilitation

PI_NAMEs: YUAN, HAN  (contact)

PROJECT_TERMS: Anatomy;Area;Artificial Intelligence;Brain;Brain imaging;Brain Neoplasms;Brain region;brain tissue;cancer imaging;Centers of Research Excellence;Clinical;Clinical Markers;Computer software;Custom;Dangerousness;Data;Decision Making;design;Diffusion Magnetic Resonance Imaging;Excision;follow-up;Fright;Functional Magnetic Resonance Imaging;functional outcomes;Glioma;Goals;graphical user interface;Human;Image;imaging biomarker;imaging modality;Imaging technology;improved;individual patient;Infiltration;innovation;Invaded;Knowledge;Language;Longitudinal Studies;Longterm Follow-up;machine learning algorithm;machine learning model;machine learning prediction;Maps;Medical center;Medical Imaging;Modality;Motor;Multimodal Imaging;multimodal neuroimaging;multimodality;Neocortex;neuroimaging;neuroimaging marker;Neurologic;Neurologic Deficit;neurological recovery;Neuronal Plasticity;neurosurgery;novel;novel strategies;Oklahoma;Operative Surgical Procedures;Outcome;outcome prediction;Outcomes Research;patient prognosis;patient safety;Patients;Performance;Postoperative Period;postoperative recovery;predict clinical outcome;predictive modeling;Probability;Progression-Free Survivals;quantitative imaging;Records;Recovery;Recovery of Function;Research;Research Project Grants;Research Support;Resected;Rest;Risk;Solid;Speech;Structure;success;support tools;surgery outcome;Survival Rate;technology development;Testing;Time;tool;Training;Transcranial magnetic stimulation;translational cancer research;tumor;Tumor Cell Invasion;United States National Institutes of Health;Visit

PROJECT_TITLE: Neuroimaging Markers for Predicting Outcome of Brain Tumor Surgery


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Wound Healing and Care

ORG_CITY: MONTREAL

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: MCGILL UNIVERSITY

ORG_STATE: QC

ORG_ZIPCODE: H3A 0G4

PHR: PROJECT NARRATIVE Voice problems constitute the most common communication disorder across the lifespan. Many malignant and benign vocal fold lesions require surgical removal using cold cutting tools or lasers, leaving a wound and in some cases a large void in the lamina propria and/or a tear in the epithelium. We are developing novel biomaterials that can be injected or deposited layer by layer into the wound site to help vocal fold tissue healing and promote the permanent regeneration of engineered tissue with the same viscoelasticity and morphology than the native uninjured lamina propria. These materials and tools would help patients with vocal fold injuries to completely recover their voice, with less hoarseness or dysphonia.

PI_NAMEs: MONGEAU, LUC  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: 3D Print;Acceleration;Acoustics;Adhesions;Adhesives;Adult;Animal Model;Animals;Atomic Force Microscopy;Benign;Biocompatible Materials;Biological;bioprinting;Bioreactors;Canada;cancer surgery;Cells;Characteristics;Chemicals;Chemistry;Child;Clinic;clinical translation;Collagen;Collagen Fiber;Communication impairment;Complement;Custom;cytotoxicity;Deposition;design;Devices;Dysphonia;Elastin;Endoscopy;Engineering;Epithelium;Excision;experimental study;Extracellular Matrix;fabrication;Foreign Bodies;Gel;General Population;glycol-chitosan;Goals;Grant;Head and neck structure;healing;Histology;Hoarseness;Human;Hydrogels;Image;Image Analysis;Immune response;Immunohistochemistry;Implant;In Situ;In Vitro;in vivo;in vivo evaluation;Incubators;Infiltration;Ingestion;Injectable;Injections;Injury;injury and repair;Lamina Propria;Laryngoscopes;Larynx;Laser Scanning Microscopy;Lasers;Legal patent;Lesion;life span;Location;Magnetic Resonance Imaging;Malignant - descriptor;manufacture;Measurement;Mechanics;Medial;Methods;Microfluidics;Morphology;Muscle;Natural regeneration;Needles;novel;nutrition;Operative Surgical Procedures;Optics;Oryctolagus cuniculus;Otolaryngology;Outcome Study;Oxygen;Pathology;Patients;Performance;Permeability;Phonation;Pilot Projects;polymerization;Polymers;Porosity;prevent;Printing;Production;Property;prophylactic;reconstruction;repaired;Resected;response;restoration;Rheology;scaffold;seal;Series;Site;Speed;Surgical Injuries;Surgical Models;Testing;Time;Tissue Engineering;tissue regeneration;Tissues;tool;Translating;United States;viscoelasticity;vocal cord;Voice;Voice Disorders;Work;wound;wound dressing

PROJECT_TITLE: Bioprintable composite materials and microfluidic tools for vocal fold restoration and repair

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Cells change shape and move, during their normal functions and during the course of various disease processes. Molecules inside the cell are responsible for cell shape and movement, and we study how these molecules work. Our results are fundamental, and they provide essential knowledge for research focused on many diseases, including cancer, infections and arthritis.

PI_NAMEs: COOPER, JOHN A (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: actin capping protein;Actins;Allosteric Regulation;Amino Acid Motifs;Arthritis;Binding;Biochemical;Biological Assay;Biological Phenomena;Biophysical Process;cancer cell;cell motility;Cell Physiology;Cell Shape;Cells;Cellular Membrane;Chimera organism;Disease;Dissociation;Endothelial Cells;Endothelium;Family;Immune;Infection;Knowledge;Lipids;Malignant Neoplasms;Measurement;Membrane;Microfilaments;migration;Molecular;Molecular Conformation;molecular dynamics;Molecular Genetics;monolayer;Motility;movie;novel;Physiological;Physiological Processes;Plus End of the Actin Filament;polymerization;Polymers;Process;protein purification;Proteins;reconstitution;Research;Shapes;Side;single-molecule FRET;Site;Surface;System;Testing;Time;Work

PROJECT_TITLE: Allosteric Regulation of Actin Capping Protein: Mechanism and Significance

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: This research application is focused on the structure and function of nicotinic acetylcholine receptors, which are neurotransmitter receptors critical for triggering muscle contraction and regulating brain function. They are major drug targets in myasthenic syndromes (muscle weakness), neurodegeneration and mental illness, and they are the targets of neuromuscular blockers used during anesthetic induction. The proposed studies will elucidate how neurotransmitters, venom toxins and modulators interact with this important class of cell surface receptors, providing essential information for improved therapeutics.

PI_NAMEs: HIBBS, RYAN E (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: addiction;Agonist;alpha Bungarotoxin;alpha-Conotoxin;Amino Acids;Anesthetics;Architecture;Autoantibodies;Binding;Biophysics;Brain;Cell Surface Receptors;cell type;Central Nervous System;Chemosensitization;Complex;computer studies;Cone;conformational conversion;Cryoelectron Microscopy;Data;density;desensitization;design;Drug Targeting;Electric Organ;Electrophysiology (science);Equilibrium;experimental study;Exposure to;Freezing;Goals;Human;improved;Inflammation;Ion Channel Gating;Ions;lens;Ligands;Lipids;Measurement;Mediating;member;Mental disorders;millisecond;Modeling;Molecular Chaperones;Molecular Conformation;molecular dynamics;Muscle;Muscle Contraction;Muscle Weakness;Mutagenesis;Mutation;Myasthenic Syndrome;N-Methyl-D-Aspartate Receptors;nanodisk;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuromuscular Blocking Agents;Neurons;neurotransmission;Neurotransmitter Receptor;Neurotransmitters;Nicotinic Receptors;particle;Peptides;Peripheral Nervous System;Permeability;Pharmacology;Physiological;positive allosteric modulator;Preparation;Property;receptor;Receptor Activation;Receptor Inhibition;reconstitution;Research;Resolution;restraint;Route;Side;simulation;small molecule;Snail Venoms;Snakes;Structure;Therapeutic;therapeutic target;Time;Torpedo;Toxin;Venoms

PROJECT_TITLE: Structural basis of nicotinic acetylcholine receptor gating and toxin inhibition


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Nanotechnology;Women's Health Research

PROJECT_TERMS: 3-Dimensional;Active Biological Transport;Address;Adopted;advanced breast cancer;Affect;Biological;Biology;Blood Vessels;blood-brain tumor barrier;Breast Cancer Patient;Breast Oncology;cancer imaging;Cancer Patient;cancer therapy;Cancerous breast;Cells;Centers of Research Excellence;chemotherapy;Clinical;Clinical Treatment;Color;Data;design;Development;diffraction of light;Diffusion;Drug Delivery Systems;drug efficacy;Electrons;Endothelial Cells;Endothelium;Engineering;Exhibits;experience;Fees;Future;Generations;Human;Image;image registration;imaging approach;imaging capabilities;imaging modality;imaging platform;improved;inhibitor;innovation;Interdisciplinary Study;Intracellular Transport;intravenous administration;Kinetics;Label;Laser Scanning Confocal Microscopy;Lasers;Lateral;light scattering;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Medical center;Medical Imaging;Mentors;Methods;Microscope;Microscopy;nanomedicine;nanoparticle;novel;Oklahoma;optical imaging;Optical Methods;Optics;Outcome;Pathway interactions;preservation;Property;Research;Research Project Grants;Research Support;Resolution;Resources;Route;Scanning;Side;spatiotemporal;Specimen;success;superresolution imaging;superresolution microscopy;synergism;systemic barrier;technology platform;Testing;Three-Dimensional Imaging;Time;Tissue Model;Tissues;transcytosis;translational cancer research;Transmission Electron Microscopy;Treatment Efficacy;tumor;Tumor Tissue;ultra high resolution;United States National Institutes of Health;Vesicle;Visualization

PROJECT_TITLE: New Ultrastructural 3D Optical Imaging of Tumor Endothelium for Cancer Nanomedicine Development


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

PHR: Project Narrative Fibrosis is a common and debilitating physiological response to injury and inflammation in many tissues and organs, however very little is known about whether there is a fibrotic response to inflammatory diseases of the central nervous system (CNS) including multiple sclerosis, neuromyelitis optica, stroke, and CNS infections. We have identified that a robust fibrotic scar forms in response to CNS neuroinflammatory lesion formation and we will test the hypothesis that a fibrotic scar limits repair following neuroinflammatory disease. We will further examine the molecular mechanisms that lead to fibrotic scar formation, with the goal of identifying potential therapeutics to aid in repair following neuroinflammatory disease.

PI_NAMEs: DANEMAN, RICHARD  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Ablation;Affect;Astrocytes;Automobile Driving;Cell Culture Techniques;Cell Proliferation;Cell secretion;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Cicatrix;Collagen;conditional knockout;Demyelinations;Deposition;Development;Disease;Event;Exclusion;Experimental Autoimmune Encephalomyelitis;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Fibrosis;Functional disorder;Ganciclovir;Goals;Heart;In Vitro;in vitro Model;in vivo;Inflammation;Inflammatory;injured;Injury;Kidney;Knockout Mice;Lead;Lesion;Liver;Lung;Mediating;Methods;migration;Modeling;Molecular;mouse model;Mouse Strains;Multiple Sclerosis;Mus;neuroinflammation;Neuromyelitis Optica;oligodendrocyte progenitor;Organ;Organ failure;Pathologic;Pathway interactions;Patients;PDGFRB gene;Pericytes;Physiological;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor alpha Receptor;precursor cell;prevent;Production;Proliferating;Recovery;Recovery of Function;recruit;repaired;reparative capacity;response;response to injury;Role;seal;Signal Pathway;Signal Transduction;single cell sequencing;Solid;Spinal cord injury;Stroke;Testing;Therapeutic;therapeutic target;Thymidine Kinase;Tissues;Transforming Growth Factor beta;Work

PROJECT_TITLE: How do CNS fibroblasts regulate the response to neuroinflammation?

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

PI_NAMEs: QIU, YUCHEN  (contact)

PROJECT_TERMS: Address;Algorithms;Bayesian Modeling;Biological Markers;BRCA mutations;CA-125 Antigen;cancer cell;Cancer Center;cancer imaging;Cancer Patient;Cancer Prognosis;cancer therapy;Characteristics;chemotherapy;Clinical;Clinical Markers;clinical practice;college;computer aided detection;Confusion;Data;Data Analyses;Data Set;Databases;Decision Making;deep neural network;Diagnosis;digital;Engineering;Evaluation;feature selection;graphical user interface;Guidelines;Gynecologic Oncology;hazard;Histopathology;Hybrids;Image;image processing;imaging biomarker;improved;interest;Learning;Machine Learning;machine learning model;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Medical center;Medical Imaging;Methods;Modeling;multidisciplinary;multimodal fusion;multimodality;Network-based;novel;Oklahoma;Oncologist;Outcome;overtreatment;particle;Pathologic;Pathology;pathology imaging;patient prognosis;patient response;patient stratification;patient subsets;Patients;Performance;personalized chemotherapy;Pharmaceutical Preparations;Physicians;Prediction of Response to Therapy;predictive modeling;predictive tools;prognostic;prognostic value;Progression-Free Survivals;prospective;Prospective Studies;quantitative imaging;radiological imaging;radiologist;Radiology Specialty;radiomics;Recurrence;Research;Research Personnel;Research Project Grants;Research Support;response;ROC Curve;Sampling;Scheme;side effect;Statistical Data Interpretation;Statistical Methods;support tools;support vector machine;Technology;technology development;technology validation;Testing;tool;Toxic effect;Training;training data;transfer learning;translational cancer research;Treatment Efficacy;treatment response;treatment strategy;tumor;tumor heterogeneity;Tumor Volume;United States National Institutes of Health;Universities;Validation;vector;X-Ray Computed Tomography

PROJECT_TITLE: Early Evaluation of Ovarian Cancer Prognosis by Fusing Radiographic and Histopathologic Imaging Information


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Liver Disease;Neurosciences;Nutrition;Obesity

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative: Understanding the autonomic regulation of the liver and manipulating the brain-liver circuit have the potential to improve hepatic glucose and lipid metabolism in patients with diabetes. The potential to target specific populations of neurons to restore metabolic homeostasis will provide novel therapeutic targets for the treatment of type 1 and type 2 diabetes.

PI_NAMEs: JO, YOUNG-HWAN  (contact);SCHWARTZ, GARY J

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Acetylcholine;Action Potentials;Acute;Address;Anatomy;Animals;Autonomic nervous system;Blood Glucose;blood glucose regulation;Brain;Cholera Toxin;Choline O-Acetyltransferase;cholinergic;Cholinergic Fibers;cholinergic neuron;Coupled;Diabetes Mellitus;Diet;diet-induced obesity;Diphtheria Toxin;dorsal motor nucleus;Energy Metabolism;Fatty acid glycerol esters;Fatty Liver;feeding;Feeding behaviors;Fiber;functional status;Genes;Glucagon;Glucose;glucose metabolism;glucose output;glucose production;Hepatic;hepatic gluconeogenesis;Hepatocyte;High Fat Diet;Homeostasis;improved;in vivo;inducible Cre;Insulin;Insulin Resistance;insulin sensitivity;interest;intrahepatic;knock-down;Link;lipid metabolism;Lipolysis;Literature;Liver;liver ablation;liver function;loss of function;mad itch virus;Metabolic;Motor Neurons;Mus;Muscarinic Acetylcholine Receptor;Nerve;nerve supply;neural circuit;Neurons;neurophysiology;new therapeutic target;Nutrient;Obese Mice;optogenetics;Pancreatic Hormones;Parasympathetic Nervous System;Patients;Photometry;Physiological;Pilot Projects;Plasma;Population;postsynaptic;Potassium Channel;presynaptic;Proteins;Publishing;Publishing Peer Reviews;receptor;Regulation;Reporter;Role;System;Testing;Thinness;Tracer;type I and type II diabetes;Work

PROJECT_TITLE: Role of cholinergic innervation of the liver

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

PI_NAMEs: DOCKERY, LAUREN ELIZABETH (contact)

PROJECT_TERMS: 3-Dimensional;Address;Animals;anti-cancer;anti-cancer treatment;anticancer activity;Antiparasitic Agents;Autopsy;benzimidazole;Binding;biomarker evaluation;biomedical imaging;Blood Vessels;Calibration;Cancer Center;Cancer Patient;cancer therapy;cancer type;Cell Death;Cells;Centers of Research Excellence;chemotherapy;Clinical;clinical application;Clinical Research;Clinical Trials;college;Data;density;Development;Diagnosis;Disease;Disease remission;Dose;drug development;drug mechanism;drug repurposing;effective therapy;efficacy evaluation;Electronics;Endoplasmic Reticulum;Engineering;Enterobius;Epithelial ovarian cancer;Epithelium;FDA approved;Fenbendazole;Fluorescence;Future;glucose uptake;Glycogen;Grant;helminth infection;high resolution imaging;Human;human subject;Hydrophobicity;Image;imaging biomarker;imaging modality;Imaging Techniques;Imaging technology;improved;in vivo;innovation;intraperitoneal;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammals;Mathematics;Measurement;Measures;Medical center;Medical Imaging;meter;Methods;Microtubule Polymerization;Modeling;Morphology;mouse model;neoplastic cell;novel;novel therapeutics;Oklahoma;Oncology;Optical Coherence Tomography;Optical Methods;Optical Tomography;Ovarian;Parasites;Patient-Focused Outcomes;Patients;Penetration;Pharmaceutical Preparations;pre-clinical;predictive modeling;Public Health;quantitative imaging;reconstruction;Recurrence;Research;Research Personnel;Research Project Grants;Research Support;Resistance development;Resolution;response;Surface;Survival Rate;Testing;Therapeutic;Therapeutic Effect;Tissue imaging;Tissues;Toxic effect;translational cancer research;Treatment Efficacy;treatment response;treatment strategy;tumor;tumor heterogeneity;tumor microenvironment;Tumor Tissue;United States National Institutes of Health;Variant;women's diagnosis;Xenograft procedure

PROJECT_TITLE: Use of 3D Quantitative Optical Methods to Optimize Mebendazole Treatment of Ovarian Cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Disability Research;Eye Disease and Disorders of Vision;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE The extent to which visual impairment is associated with the patterns of the longitudinal cognitive trajectory of aging adult is unclear. The goal of this proposal is to evaluate the complex associations among visual impairment, brain neurodegeneration, CVD risk factors, APOE ε4 genotype, and other sociopsychological factors as they relate to the longitudinal trajectories of cognitive decline and the linking mechanisms between visual impairment and cognitive decline. Visual impairment is a prevalent condition that is highly treatable and represents an important modifiable risk factor that can be prevented and treated as an effective means to preserve cognitive function and improve quality of life.

PI_NAMEs: ZHENG, DANDAN DIANE (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Aging;aging process;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;biobank;Brain;brain magnetic resonance imaging;cardiovascular disorder risk;cerebrovascular;Cerebrovascular Disorders;Characteristics;Chronic;Clinical;Clinical assessments;Cognition;Cognitive;cognitive function;cognitive neuroscience;cognitive reserve;cohort;Communities;Complex;Contrast Sensitivity;Data;Data Sources;Dementia;Development;Disabling condition;Disease;Epidemiology;epidemiology study;Equation;Etiology;experience;Eye diseases;Fostering;Future;Genetic;Genotype;Goals;Health;Impaired cognition;improved;K-Series Research Career Programs;Life;Link;Measures;Mediating;Mental Depression;Mentorship;Microvascular Dysfunction;middle age;Modeling;modifiable risk;Nerve Degeneration;neuroimaging;normal aging;novel;older adult;Older Population;Outcome;Pathway interactions;Pattern;Play;preservation;prevent;programs;psychologic;Psychological Factors;Quality of life;Research;Research Personnel;Risk;Risk Factors;Role;Scientist;sex;skills;social;social engagement;Social isolation;Statistical Methods;Statistical Models;statistics;Structure;Techniques;Thick;Training;Training Activity;Vision;Vision Disorders;Visual Acuity;Visual impairment;White Matter Hyperintensity

PROJECT_TITLE: Visual impairment and cognitive decline: understanding the longitudinal relationships and mechanisms

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Microbiome;Nutrition;Physical Injury - Accidents and Adverse Effects

ORG_CITY: MEMPHIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Public exposure to radiation by large-scale radiation incidents is a rising global concern, but there are no FDA-approved therapeutics for radiation injury. Therefore, we propose to conduct studies to uncover the cellular and molecular mechanisms involved in Lactobacillus-mediated mitigation of radiation injury. The outcome of these studies will identify a new medical countermeasure to treat radiation injury by targeting the gut microbiota.

PI_NAMEs: RAO, RADHAKRISHNA  (contact)

PROGRAM_OFFICER_NAME: RIOS, CARMEN I

PROJECT_TERMS: Actins;alpha-Defensins;Animal Model;animal rule;Anti-Bacterial Agents;attenuation;Bacteria;Biological;Biology;Caco-2 Cells;Cancer Patient;cancer radiation therapy;Cells;Colon;Cyclic AMP-Dependent Protein Kinases;Cytoskeleton;Data;Diet;Dose;Down-Regulation;dysbiosis;Effectiveness;Endotoxemia;Epidermal Growth Factor Receptor;Epithelium;Exhibits;Exposure to;FDA approved;Filtration;Functional disorder;gastrointestinal;gastrointestinal epithelium;Goals;gut dysbiosis;gut microbiome;gut microbiota;Histone Deacetylase;Histone Deacetylation;Hour;Human;insect defensin A;intestinal barrier;intestinal epithelium;Intestinal Mucosa;Intestines;Ionizing radiation;irradiation;knockout gene;Knockout Mice;Lactic acid;Lactobacillus;Lactobacillus casei;Lactobacillus plantarum;MAPK8 gene;Mediating;medical countermeasure;microbiome;microbiome alteration;microbiome analysis;microbiota;microbiota composition;Molecular;monolayer;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mucous Membrane;Mus;novel;Nuclear Accidents;Oral Administration;Organoids;Outcome Study;Paneth Cells;Pathogenesis;Peptides;Play;Predisposition;probiotic therapy;Probiotics;Protein Kinase C;Proteins;Qualifying;Radiation;Radiation Accidents;Radiation Enteritis;Radiation exposure;Radiation Injuries;radiation mitigation;radiation response;Radiation Toxicity;receptors for activated C kinase;Research;Role;SRC gene;Survival Rate;systemic inflammatory response;Testing;Therapeutic;Tight Junctions;Time;Tyrosine Phosphorylation

PROJECT_TITLE: Mitigation of GI-ARS by Lactobacillus species


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE This K24 Mid-Career Investigator Career Development Award in Patient-Oriented Research seeks support for Christopher Pittenger, a tenured Associate Professor of Psychiatry at Yale University and Director of the Yale OCD Research Clinic; training and mentorship activities supported by this award will take place in the context of two NIMH-funded projects, R01 MH100068 and R01 MH116038. The Award will support Dr. Pittenger in a robust training plan aimed at increasing his skills in statistics and in the design and analysis of fMRI experiments, with the goal of making him a more effective collaborator and mentor in these domains. The robust Mentorship Plan supports a range of trainees, from high school students through junior faculty, with a particular focus on the research track with the Yale Psychiatry Residency, of which Dr. Pittenger will become the Director in the coming years.

PI_NAMEs: PITTENGER, CHRISTOPHER JOHN (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Achievement;Adult;Area;Award;Brain;career;career development;Clinic;Clinical;Code;Collaborations;connectome;Data;Data Analyses;Dedications;Department chair;design;Disease;disorder control;Dissociation;Doctor of Philosophy;Double-Blind Method;Drug Exposure;Educational process of instructing;experimental study;Faculty;Feedback;Fluoxetine;Fostering;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Future;Generations;Gilles de la Tourette syndrome;Goals;Grant;graph theory;Health Sciences;High School Student;Human;Image;Imaging technology;improved;Individual;Infrastructure;innovation;insight;K-Series Research Career Programs;Lead;Leadership;Linux;Machine Learning;Mentors;Mentorship;mid-career faculty;Motivation;National Institute of Mental Health;Neurobiology;neurofeedback;neuroimaging;Neurosciences;Neurosciences Research;next generation;novel;Obsessive-Compulsive Disorder;patient oriented;patient oriented research;Pharmaceutical Preparations;Pharmacotherapy;Physicians;Positioning Attribute;Postdoctoral Fellow;Preceptorship;predicting response;Prediction of Response to Therapy;programs;Protocols documentation;Psychiatry;Publishing;Pythons;Research;Research Ethics;Research Personnel;Research Project Grants;research study;Residencies;Rest;Scanning;Scientist;Services;simulation;skills;Statistical Methods;statistics;Structure;Students;success;symptomatic improvement;symptomatology;teacher;Time;Training;Training Activity;Training Programs;Training Support;Translational Research;Universities;Work

PROJECT_TITLE: Patient Oriented Research and Mentorship and Training in Functional Neuroimaging of Obsessive-Compulsive Disorder


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Using combined genetic, biochemical, spectroscopic and structural approaches, we propose to investigate a novel mechanism of N2 reduction that involves dynamic structural rearrangements of the active site of Mo-nitrogenase. Through our proposed studies, we hope to facilitate a (re)calibration of the mechanistic thinking of nitrogenase and establish a framework for further mechanistic exploration of this intricate reaction. Success along this line will not only lead to a molecular depiction of the intricate catalytic mechanism of nitrogenase, but also facilitate development of nitrogenase-based applications in the long run.

PI_NAMEs: HU, YILIN  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Probing a novel reaction mechanism of nitrogenase with dynamic active-site rearrangements

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

PHR: Project Narrative The proposed “Child Mental Health in HIV-impacted Low-resource settings in Developing countries: Global Research Fellowship” (CHILD-GRF) training program will support the development of a cadre of 18 well- trained, culturally-embedded in-country scientists from Uganda to conduct child and adolescent mental health (CAMH) research in the context of HIV/AIDS using rigorous and culturally-congruent research methods. This will ultimately provide a robust platform for the development and implementation of culturally-congruent evidence-based HIV prevention and CAMH interventions for youth and families living in communities heavily impacted by HIV/AIDS. By producing a sustainable network of individuals in key research institutions who are well trained in various aspects of CAMH, HIV/AIDS research, and dissemination & implementation research, this training program, in partnership with Makerere University in Uganda, will contribute to improving CAMH and HIV prevention efforts, both of which have implications for public health.

PI_NAMEs: MCKAY, MARY MCKERNAN;NAKASUJJA, NOELINE ;SSEWAMALA, FRED M (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;adolescent mental health;Affect;African;AIDS prevention;Applications Grants;Area;career;Caring;Child;Child Mental Health;Collaborations;Communities;community violence;Country;Developing Countries;Ensure;Epidemic;expectation;experience;Extramural Activities;Faculty;Fellowship;Fostering;Funding;hands on research;hands-on learning;HIV;HIV/AIDS;Individual;Institution;institutional capacity;Intervention;low and middle-income countries;Manuscripts;Mental Health;Mentors;Mentorship;Methods;multidisciplinary;Peer Review;Pilot Projects;Poverty;Preparation;Prevention;preventive intervention;Principal Investigator;Program Evaluation;programs;recruit;Research;Research Personnel;Research Project Grants;Resource-limited setting;Scientist;Site Visit;Structure;success;Training;Training and Infrastructure;Training Programs;Uganda;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: Child Mental Health in HIV-impacted Low-Resource Settings in Developing Countries: Global Research Fellowship


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hematology;Liver Disease;Orphan Drug;Rare Diseases;Sickle Cell Disease

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative: High iron stores are toxic due to metal-induced oxidative stress that promotes multiple organ damage, including cardiomyopathy, liver cirrhosis, hypertriglyceridemia, diabetes, and premature death. Using an iron chelator-coated ultrasmall nanochelator that captures iron from the plasma and liver, without distributing it into non-target tissues, we aim to develop subcutaneous injectable hydrogel formulations with increased exposure for 3 weeks. This strategy can decrease body iron burden and reduce the risk of iron-mediated organ toxicity, without overt chelator-related side effects.

PI_NAMEs: CHOI, HAK SOO  (contact);KIM, JONGHAN

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: absorption;Adverse effects;Affect;Agranulocytosis;Anemia;Animal Model;Animals;Arthritis;Biochemical;Biological Availability;Blood;Blood Transfusion;Cardiomyopathies;Caucasians;Cessation of life;Chelating Agents;Chelation Therapy;Chemistry;Chronic;Clinical;Clinical Trials;Column Chromatography;Communication;Continuous Infusion;Cyclic GMP;Deferoxamine;design;Diabetes Mellitus;Dialysis procedure;Diamond-Blackfan anemia;Disease;Dose;Dose Limiting;Drug or chemical Tissue Distribution;Dyslipidemias;Dysmyelopoietic Syndromes;efficacy evaluation;Engineering;Excision;Excretory function;Family suidae;FDA approved;Ferritin;Formulation;Freeze Drying;Future;Gastrointestinal Hemorrhage;Genetic Diseases;Grant;Half-Life;heart damage;Heart failure;heart function;Hematopoietic;Hepatic;Hereditary hemochromatosis;Hydrogels;Hypertriglyceridemia;Hypotension;imaging system;immunogenicity;Impairment;improved;Infection;Inflammation;Infusion procedures;Injectable;injection/infusion;Injections;Intravenous;Iron;iron absorption;Iron Chelating Agents;Iron Chelation;Iron Overload;Kidney;Kinetics;Liver;Liver Cirrhosis;Liver Failure;Liver Fibrosis;Marketing;Maximum Tolerated Dose;Mediating;Metabolic syndrome;Metals;milligram;Modeling;Morbidity - disease rate;mortality;Multimodal Imaging;Mus;nano;National Heart, Lung, and Blood Institute;Nature;nephrotoxicity;Neurodegenerative Disorders;novel;novel therapeutic intervention;Nutritional;Obesity;older patient;Oral;Organ;Organic Synthesis;Oxidative Stress;Oxidative Stress Induction;parenteral administration;Patient Compliance;Patients;Pattern;Persons;Plasma;Polymers;Population;Predisposition;premature;Procedures;prototype;Publications;Rattus;Reactive Oxygen Species;Reporting;residence;response;Risk Factors;Risk Reduction;Rodent;Safety;scale up;Sickle Cell Anemia;side effect;Site;small molecule;Solvents;standard care;subcutaneous;Subcutaneous Injections;systemic toxicity;Tablets;Thalassemia;Therapeutic;therapy outcome;Tissues;Toxic effect;Toxicity Tests;Transfusion;treatment adherence;Treatment Efficacy;United States National Institutes of Health;uptake;urinary;Urine

PROJECT_TITLE: Long-Acting, Short-Residing Nanochelators for Iron Overload Therapy

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Precision Medicine;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Relevance Cancer researchers have identified genes and molecules that directly drive the proliferation, survival and metastasis of cancer cells. In addition, genes have been identified that can direct an altruistic form of cellular suicide that protects the organism from mistakes in development or DNA replication. We are developing small molecules, which we call TCIPs (Transcriptional Chemical Inducers of Proximity) that rewire the cancer cell to kill itself with its own driver and may enable an entirely new, less toxic and more effective approach to the treatment of blood cancers.

PI_NAMEs: CRABTREE, GERALD R. (contact);GRAY, NATHANAEL SCHIANDER

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Address;Altruism;anti-cancer research;Apoptosis;Apoptotic;B-Cell Lymphoma 6 Protein;B-Cell Lymphomas;B-Lymphocytes;BCL6 gene;Binding;Biology;blood treatment;Cancer Biology;cancer cell;Cancer Center;Cancer Etiology;cancer genomics;cancer therapy;Cell Death;Cell Death Induction;Cell Line;cell suicide;Cells;Characteristics;Chemicals;Chemistry;Chemotherapy-Oncologic Procedure;Clinical;clinical development;Collaborations;Complex;Consult;Dana-Farber Cancer Institute;Data;Defect;derepression;Development;Diffuse;DNA biosynthesis;Dominant Genetic Conditions;effectiveness evaluation;Epigenetic Process;Estrogen Receptors;Foundations;gain of function;gain of function mutation;Genes;Genetic Transcription;Genomics;Hematopoietic Neoplasms;Histone Deacetylation;Human;inhibitor;interdisciplinary approach;invention;Lead;Lymphoma;Lymphoma cell;Maintenance;Malignant Neoplasms;Mediating;Modeling;Mutation;Neoplasm Metastasis;Normal Cell;novel;off-target site;Organism;overexpression;Pathway interactions;patient derived xenograft model;personalized medicine;Polycomb;Precision cancer therapy;Proliferating;promoter;Proteins;Publishing;recruit;Reporting;Repression;Research Personnel;Role;Side;small molecule;Solubility;Specificity;Testing;Therapeutic;therapeutic development;Toxic effect;TP53 gene;Transcription Coactivator;transcription factor

PROJECT_TITLE: HIJACKING CANCER DRIVERS TO ACTIVATE PROAPOPTOTIC GENES IN DLBCL

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Cardiovascular;Estrogen;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Infectious Diseases;Sepsis;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative/Relevance  Sex-specific differences exist in the cardiovascular system following acute injury and female hormone - estrogen is one critical factor to mediate such disparity. Our project aimed at investigating sex-related cardiac mitochondrial responses to inflammatory cytokine and systematically evaluating rapid action of estrogen on preventing mitochondrial dysfunction. These findings will greatly improve our scientific knowledge and offer the basis of developing novel interventions for cardiac recovery.

PI_NAMEs: WANG, MEIJING  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Ablation;Acute;Attention;Binding;Cardiac;Cardiac ablation;Cardiac Myoblasts;Cardiac Myocytes;Cardiomyopathies;Cardiovascular system;Caveolae;caveolin-3;cecal ligation puncture;Clinical;Communication;Connexin 43;cytokine;Data;Disparity;Doxycycline;effective intervention;engineered exosomes;ESR1 gene;Estradiol;Estrogen Receptors;Estrogens;exosome;Exposure to;Female;Functional disorder;Goals;Health;Heart;heart damage;heart function;Heart Mitochondria;heart preservation;Hormones;Impairment;improved;Inflammation;Inflammation Mediators;Inflammatory;Injury;insight;Intervention;Ischemia;knock-down;Knockout Mice;Knowledge;Link;Lipopolysaccharides;male;Mediating;Mitochondria;mitochondrial dysfunction;Modeling;Mus;Myoblasts;Myocardial;Myocardial dysfunction;Myocardial Ischemia;Myocardium;novel;novel strategies;Organelles;Outcome;patient prognosis;Peptides;Performance;Phosphorylation;preservation;prevent;Protein Isoforms;receptor;Receptor Activation;Receptors, Tumor Necrosis Factor, Type II;Recovery;Reperfusion Therapy;resilience;Resistance;response;Role;Sepsis;septic;Severities;sex;Sex Differences;sex disparity;sexual dimorphism;Signal Transduction;Stress;Structural Protein;Testing;Therapeutic;therapeutic target;TNFRSF1B gene;Trauma;Work

PROJECT_TITLE: Sex-related differences in cardiac mitochondrial response to inflammation

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]