ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: BOZEMAN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Project Narrative MT INBRE V will catalyze and strengthen biomedical and health science research across a culturally and economically diverse network by valuing inclusivity and embracing all perspectives. The goal of this program is to use research to address health disparities in rural and tribal communities in Montana.

PI_NAMEs: BOTHNER, BRIAN P (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: Address;American Indians;base;Behavioral Sciences;Biomedical Research;biomedical scientist;Brain Drains;career;Centers of Research Excellence;Charge;Clinical;Collaborations;college;Communities;community based participatory research;community college;community engagement;course development;COVID-19;Data;Data Science;Data Science Core;Development;Education;Employment;Environment;Environmental Health;Equity;Event;experience;extreme weather;Faculty;faculty mentor;Fire - disasters;Floods;Foundations;Goals;graduate student;Health;health disparity;health science research;Health Status;Healthcare;holistic approach;improved;Individual;infrastructure development;Institution;interdisciplinary approach;Interdisciplinary Study;Intervention;Investments;Medical Records;medical schools;member;Mentors;Montana;Native American community;Outcome Measure;Personal Satisfaction;Persons;Pharmaceutical Preparations;Postdoctoral Fellow;programs;Public Health;Reduce health disparities;reduce symptoms;Research;Research Personnel;Research Project Grants;Reservations;Resources;Rural;rural Americans;Rural Community;Rural Health;Rural health equity;Science;Social Sciences;student participation;Students;success;Targeted Research;Training;training opportunity;tribal college;tribal community;tribal health;undergraduate education;undergraduate student;United States National Institutes of Health;Universities;Workforce Development;working group

PROJECT_TITLE: MT INBRE: A Multidisciplinary Research Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-7 (IN)]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Rural Health

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PROJECT_TERMS: Address;Advisory Committees;Attention;Award;Behavioral Sciences;Biomedical Research;Brain Drains;career;career development;Collaborations;college;Communication;Communities;community engagement;Consultations;Data Collection;Data Science;Data Science Core;Development;Education;Ensure;Equity;Evaluation;Event;evidence base;experience;Face;Faculty;Faculty Recruitment;faculty support;formative assessment;Fostering;Funding;Goals;graduate student;Grant;Health;health science research;Heterogeneity;Home;Human Resources;improved;Infrastructure;Institution;Interdisciplinary Study;interest;Internships;Joints;Leadership;Learning;meetings;Monitor;Montana;Motivation;Performance;Program Evaluation;Program Research Project Grants;programs;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;Rural;Rural Community;Schedule;science education;Scientific Inquiry;Social Sciences;student training;Students;success;symposium;synergism;Teacher Professional Development;Technology;Time;Training;Translating;tribal college;tribal community;undergraduate student;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Prevention;Rural Health

PI_NAMEs: QUINN, MARK T (contact)

PROJECT_TERMS: Achievement;Address;Area;Award;Biomedical Research;career;career development;Categories;Collaborations;Communicable Diseases;Communities;community based participatory research;community college;community engagement;Core Facility;Data Science Core;Development;Diverse Workforce;Education;Educational process of instructing;Environment;Face;Faculty;faculty research;food security;Fostering;Funding;Funding Opportunities;Goals;graduate student;Grant;Growth;Health;health disparity;health science research;Healthcare;Heterogeneity;improved;Infrastructure;Institution;inter-institutional;interdisciplinary collaboration;Interdisciplinary Study;interest;Investments;Joints;Link;member;Mental Health;Mentors;Metabolic Diseases;Montana;Native Americans;nutrition;Outcome;Prevention;Productivity;Program Research Project Grants;programs;Research;research and development;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Rural;Rural Community;Science;student retention;student training;Students;Suicide prevention;Symptoms;Teacher Professional Development;Training;tribal college;tribal community;undergraduate research experience;undergraduate student;Universities;Workforce Development

PROJECT_TITLE: Developmental Research Project Program


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: BERTAGNOLLI, ANN THERESE (contact)

PROJECT_TERMS: American Indians;Authorship;Centers of Research Excellence;climate change;climate impact;Collaborations;college;Communities;community academic partnership;community advisory board;community based participatory research;community collaboration;community engagement;community partners;community partnership;Complement;Data;data sharing;Discipline of Nursing;Dissemination and Implementation;Droughts;Ecosystem;Education;Ensure;Equity;food security;Foundations;Funding;Grant;Health;health disparity;health equity;Healthcare;Human;improved;Institution;Interdisciplinary Study;Intervention;investigator training;Knowledge;lung health;Malignant Neoplasms;Manuscripts;Modeling;Montana;Multiple Partners;Native American population;Outcome;Outcomes Research;Phase;Population;Postdoctoral Fellow;programs;Public Health;Publications;Research;research and development;Research Personnel;research study;Reservations;rural Americans;Rural Community;Rural Health;Rural health equity;Rural Population;Services;Side;Solid;Students;success;therapy development;timeline;tool;Training;Training Activity;translational health science;United States National Library of Medicine;Universities;Utah;Vision;Washington;water quality;webinar;Wildfire;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rural Health

PI_NAMEs: GOOD, JEFFREY  (contact)

PROJECT_TERMS: Active Learning;Adoption;Artificial Intelligence;Bachelor's Degree;Behavioral Research;Big Data;Bioinformatics;biomarker discovery;Biomedical Research;Centers for Population Health;Cloud Computing;Collaborations;Collection;Communities;community based participatory research;community engagement;Community Health;community involvement;community science;complex data;Computational Science;computer science;Computer software;computing resources;Core Facility;Data;Data Analyses;Data Collection;data management;Data Science;Data Science Core;Data Scientist;Data Set;data streams;Degree program;Ecology;Education;Educational Curriculum;Educational workshop;Elements;Ensure;Event;experience;Faculty;flexibility;genomic data;Genomics;Goals;Health;health science research;High Performance Computing;Human;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;Intervention;Investments;Learning;Machine Learning;Medical Records;metabolomics;Montana;Outcome;Play;population health;Positioning Attribute;Problem Solving;programs;Qualifying;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;Role;Rural Health;Site;social;Social Sciences;Students;success;Trainers Training;Training;training opportunity;tribal college;undergraduate student;Universities;Work

PROJECT_TITLE: Data Science Core


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The goal of this proposal is to make available to scientists worldwide the next generation human MRI scanner for mapping the microscopic, mesoscopic, and macroscopic connections in the human brain known as Connectome 2.0, located at the Massachusetts General Hospital. This scanner will dramatically change our ability to visualize the microscopic structure of the human brain and advance our understanding of how the brain works and changes in learning, memory, aging, and pathology. We will create the infrastructure to enable broad and efficient use of this scanner, by enabling in-person and remote access for international teams of neuroscientists, physicists, engineers, and clinicians to use the Connectome 2.0 MRI scanner and allow this new research tool to reach the widest audience possible.

PI_NAMEs: HUANG, SUSIE YI (contact)

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Animal Disease Models;Architecture;autism spectrum disorder;Axon;Brain;Brain imaging;BRAIN initiative;Brain Mapping;Brain region;brain tissue;Calibration;Cell Density;cell type;Cellular Structures;Cognitive;Collaborations;Communities;computerized data processing;connectome;Custom;Data;data acquisition;data exchange;design;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Discipline;Engineering;Ensure;Funding;General Hospitals;Generations;Goals;Grant;Growth;Head;Heterogeneity;Hospital Design;Human;human imaging;Human Resources;human tissue;Image;image processing;image reconstruction;Imaging Device;imaging modality;improved;in vivo;Individual;Infrastructure;innovation;innovative neurotechnologies;Institution;instrument;interest;International;Learning;Liquid substance;Magnetic Resonance Imaging;Maps;Massachusetts;Measurement;Memory;Mental disorders;meter;Methods;Microscopic;millimeter;Monitor;Morphologic artifacts;Multiple Sclerosis;Nerve Fibers;Nervous System Disorder;neural;neural circuit;Neuroanatomy;neuroimaging;Neuronal Plasticity;Neurons;Neurosciences;next generation;non-invasive imaging;novel;Pathology;Persons;Phase;Physics;Physiologic pulse;Procedures;Publications;quality assurance;reconstruction;recruit;Research;Research Personnel;Resolution;Resource Sharing;Resources;Schizophrenia;Scientific Advances and Accomplishments;Scientist;Shapes;Specificity;structural imaging;Structure;success;System;Techniques;Technology;technology development;Time;Tissues;tool;tractography;Training;Traumatic Brain Injury;United States National Institutes of Health;Validation;Visualization;Work

PROJECT_TITLE: Connectome 2.0: A BRAIN Technology Integration and Dissemination Resource for Ultra-High Gradient Magnetic Resonance Imaging of Human Brain Circuits Across Scales

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-S (16)]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: B. Project Narrative Transgender/gender expansive (TGGE) individuals are understudied, underrepresented, and underreported in health research, despite facing enormous gender inequities that affect morbidity and mortality. The Healthcare Interprofessional Gender Health, Education and Research (HIGHER) Academy will augment the workforce of researchers focusing on the health of TGGE individuals by creating an adaptable, reproducible, sustainable research course for interprofessional graduate students that is taught exclusively by TGGE individuals and cisgender women. A community-academic advisory board will be involved in the oversight and evaluation of this initiative, which will also solidify a community of practice among researchers at a large urban, public university to serve as mentors and instructors to the scholars.

PI_NAMEs: STRYKER, SHANNA D (contact)

PROGRAM_OFFICER_NAME: BARR, ELIZABETH ANNE

PROJECT_TERMS: Academy;Active Learning;Address;Affect;age stratification;Allied Health Sciences;Arts;Basic Science;Birth;Case Study;cis-female;clinical care;Clinical Research;Collaborations;college;Communities;community advisory board;community engagement;Community Health;Community of Practice;community organizations;Course Content;Data;Death Rate;Dedications;design;Development;Discipline of Nursing;Education;education research;Educational Curriculum;Educational process of instructing;Ethics;Evaluation;expectation;experience;Faculty;Federally Qualified Health Center;Gender;gender affirming care;Gender expansive;Gender Identity;graduate student;Health;health care availability;health disparity;Health Personnel;Health Professional;Healthcare;Human;improved;Individual;Inequity;Information Dissemination;innovation;Institution;instructor;intersectionality;Knowledge;Learning;learning community;Lived experience;Medical;Medicine;member;Mental Health;Mentors;Mentorship;Methods;Minority;Morbidity - disease rate;mortality;Needs Assessment;Operative Surgical Procedures;Participant;patient engagement;Patient Recruitments;Performance;personalized care;Persons;Pharmacy facility;physical conditioning;Policies;Problem Solving;Process;programs;Public Health;Recommendation;Reproducibility;Research;Research Activity;research and development;Research Methodology;Research Personnel;Research Priority;Research Proposals;research study;Research Training;Resource Sharing;Resources;Scholars Program;Science;Services;sex;skills;social;social learning;Societies;Students;success;symposium;System;Training;Training and Education;transgender;Universities;virtual;virtual environment

PROJECT_TITLE: The HIGHER Academy: Healthcare Interprofessional Gender Health, Education and Research Academy for Gender Expansive Health Research Training and Collaboration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-P (57)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: INDIANAPOLIS

ORG_DEPT: CHEMISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Molybdenum cofactor (Moco) is an indispensable molecule to human health and its absence causes severe physiological disorders. To date, complete synthesis of Moco has not been achieved and its fundamental chemical proper<es are not well understood. This proposal seeks to synthesize Moco and its components, and inves<gate its proper<es through chemical, biochemical and biophysical studies.

PI_NAMEs: BASU, PARTHA  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Aldehyde oxidase;Amino Acids;Anabolism;autosome;Biochemical;biophysical analysis;Cessation of life;chemical synthesis;Chemicals;Chemistry;Childhood;Classification;Coenzymes;cofactor;Combined molybdoflavoprotein enzyme deficiency;Complex;Cryoelectron Microscopy;Crystallography;Cysteine;density;Dimethyl Sulfoxide;dimethyl sulfoxide reductase;Disease;Distress;Electrochemistry;electron donor;Electron Spin Resonance Spectroscopy;Electron Transport;electronic structure;Electronics;Electrons;Environment;Enzymes;Failure;Family;Gastrointestinal tract structure;geometric structure;Health;Human;Hydrogen Bonding;Investigation;Kinetics;Knowledge;Life;Ligands;Mass Spectrum Analysis;member;Metals;microorganism;Modeling;Molecular;molybdenum cofactor;Monitor;Mutate;Nitrate Reductases;Nitrates;NMR Spectroscopy;Oxidants;oxidation;Oxidation-Reduction;periplasm;Phosphorylation;Physiological;Process;Property;Proteins;prototype;Pterins;pyranopterin;Pyrans;Reaction;Research;Resources;respiratory;Serine;spectroscopic survey;Spectrum Analysis;Structure;success;sulfite oxidase;Techniques;Testing;theories;trimethyloxamine;Variant;Work;X-Ray Crystallography;Xanthine Oxidase

PROJECT_TITLE: Investigation of Molybdenum Cofactor through Chemical, Biochemical and Biophysical Studies

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Dementia;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: EAST LANSING

ORG_DEPT: PHYSIOLOGY

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: PROJECT NARRATIVE Traumatic Brain Injury (TBI) is a major global and domestic health issue and a potential risk factor for developing Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD), and for which there are no FDA- approved effective treatments. We have found that a tetrapeptide N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is a novel candidate as a potential treatment for TBI. The proposed studies will elucidate the mechanisms underlying the therapeutic effects of AcSDKP and help to develop AcSDKP as an effective therapy for TBI.

PI_NAMEs: XIONG, YE  (contact);ZHANG, LI

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acetylation;Alzheimer's Disease;Alzheimer's disease related dementia;angiogenesis;Angioneurotic Edema;Angiotensin I;Angiotensin II;Angiotensin-Converting Enzyme Inhibitors;Axon;Brain;Cell Nucleus;Clinical Trials;clinically relevant;Cognitive;controlled cortical impact;Contusions;Data;Development;Diabetes Mellitus;dosage;Dose;Early treatment;effective intervention;effective therapy;FDA approved;Female;Fibrin;Fibrosis;Fostering;Functional disorder;functional improvement;Goals;goralatide;HDAC4 gene;Health;Heart Diseases;Hippocampus;Histone H3;hypertension control;Hypotension;immunoregulation;improved;Inflammation;Infusion procedures;Injury;Innovative Therapy;kidney fibrosis;Learning;Lesion;Literature;Long term disability;male;Memory;Modeling;Molecular;neurogenesis;neuroinflammation;neuron loss;Neurons;neuroprotection;neurovascular;novel;novel therapeutics;Nuclear;Nuclear Translocation;Outcome;Peptides;Peptidyl-Dipeptidase A;Pharmaceutical Preparations;Plasma;Play;pre-clinical;prevent;Process;Proline;Public Health;Quality of life;Rattus;Recovery of Function;Regenerative capacity;repaired;Research;response;Risk Factors;side effect;Signal Pathway;Signal Transduction;subcutaneous;Synaptic plasticity;synaptogenesis;TBI Patients;TBI treatment;Testing;TGFB1 gene;Therapeutic;Therapeutic Agents;Therapeutic Effect;therapeutically effective;Thymosin;Time;Tissues;Traumatic Brain Injury;Traumatic Brain Injury recovery;United States

PROJECT_TITLE: AcSDKP as a novel treatment for traumatic brain injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Contraception/Reproduction;Infertility

ORG_CITY: MILWAUKEE

ORG_DEPT: BIOLOGY

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: PROJECT NARRATIVE In animals from humans to nematodes, high temperatures stress result in sterility. In this grant we are investigating two fundamental structures found in the cells that make sperm and egg, the synaptonemal complex and P granules, and how during high temperatures stress these structures may fail, potentially leading to sterility. By investigating a number of species that lose fertility at different temperatures, we hope to identify mechanisms by which key structures in sperm and egg cells may be preserved, thus preserving species’ fertility during high temperature stress.

PI_NAMEs: PETRELLA, LISA NICOLE (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Affect;Animals;Caenorhabditis;Caenorhabditis elegans;Cells;Cessation of life;Climate;Communication;comparative;Cytoplasmic Granules;Data Analyses;Development;Disease;Education;egg;Embryo;Exhibits;experience;Experimental Designs;experimental study;Exposure to;Failure;Female;Fertility;Fertility Disorders;Genetic Research;Germ;Germ Cells;Germ Lines;Goals;graduate student;Grant;High temperature of physical object;Human;Infertility;Laboratories;Lead;Link;Liquid substance;male;Meiosis;Modeling;Nematoda;Oral;Pathway interactions;physical property;preservation;Process;Property;protein aggregation;Proteins;Research;Research Personnel;response;role model;sperm cell;Sterility;Stress;stress granule;Structure;student mentoring;Students;Synaptonemal Complex;Syp protein;Temperature;Testing;undergraduate student;Work;Writing

PROJECT_TITLE: Temperature-sensitive germline structures and temperature thresholds of fertility in Caenorhabditis nematodes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-C (81)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Prevention

ORG_CITY: FAYETTEVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: PROJECT NARRATIVE This project aims to evaluate distress tolerance as a mechanism of psychotherapeutic change by specifically exploring willingness to experience distress and self-efficacy for withstanding distress on emotion regulation strategies used in daily life and subsequent symptoms of psychopathology and well-being. The objectives of this proposal are consistent with the goals of the NIH Academic Research Enhancement Award (AREA) R15 program and will have a significant impact on public health by evaluating specific therapeutic skills and how they target real-world actions taken to manage upsetting emotions. This project uses an experimental therapeutics approach and fits with the strategic mission of the NIMH to improve both prevention and treatment for a key transdiagnostic mental health concern.

PI_NAMEs: VEILLEUX, JENNIFER CELENE (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Academic Research Enhancement Awards;anxiety symptoms;Award;Behavior;Behavior Control;Cognitive;Curiosities;daily functioning;depressive symptoms;Diagnostic;Dialectical behavior therapy;distraction;Distress;distress tolerance;Ecological momentary assessment;Elements;emotion regulation;Emotional;emotional experience;Emotions;experience;Feeling;follow-up;Foundations;Funding Mechanisms;Future;Goals;graduate student;Grant;improved;innovation;Intervention;intervention effect;Investigational Therapies;Knowledge;Label;Life;Link;Maps;Mental disorders;Mental Health;Methods;Mission;Motivation;National Institute of Mental Health;negative affect;Negative Valence;Outcome;Participant;Personal Satisfaction;personalized care;Persons;Prediction of Response to Therapy;prevent;Prevention;Process;Protocols documentation;psychoeducation;psychologic;Psychopathology;Psychotherapy;Public Health;Randomized;reduce symptoms;Reporting;Research;Research Domain Criteria;Research Training;Risk Factors;Role;Self Efficacy;Series;skills;social;Strategic Planning;symptomatic improvement;Symptoms;System;Testing;theories;Therapeutic;Thinking;Time;Training;treatment effect;Treatment outcome;undergraduate student;United States National Institutes of Health;Unmarried person;willingness

PROJECT_TITLE: Targeting components of distress tolerance

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Regenerative Medicine;Wound Healing and Care

PHR: PROJECT NARRATIVE Chronic skin wounds are a serious problem that affect the health and quality of life of millions of Americans and create a significant financial burden on the entire health care system. Growth factors are small signaling proteins that can in principle stimulate tissue repair, but rapidly lose their bioactivity and show poor clinical efficacy. Hyper- stable growth factors and a hydrogel wound dressing to be developed and validated here will enable sustained release of persistent growth factors and a protective environment for improved healing of chronic wounds.

PI_NAMEs: THALLAPURANAM, SURESH KUMAR KRISHNASWAMY (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acceleration;acrylic acid;Address;Affect;Age;American;angiogenesis;Anti-diabetic Drugs;Biological Assay;Biological Markers;biomaterial compatibility;Biomedical Research;Bone callus;cancer type;Cardiovascular Diseases;career;Cell Adhesion;cell growth;Cell Physiology;Cell Proliferation;Charge;chronic ulcer;chronic wound;Clinical;clinical efficacy;Clinical Research;collaborative environment;Collagen;controlled release;copolymer;cost;Death Rate;decubitus ulcer;density;design;Development;Diabetes Mellitus;Diabetic Foot Ulcer;diabetic ulcer;diffuse reflectance spectroscopy;dimer;Drug Kinetics;efficacy evaluation;Electrostatics;Engineering;Environment;ethylene glycol;Exhibits;FGF1 gene;FGF2 gene;Fibroblast Growth Factor;Filler;Financial Hardship;Fluorescence;Formulation;Gel;Gelatin;Glucose;Growth Factor;healing;Health;Healthcare Systems;Hydrogels;imaging approach;improved;in vivo;Incidence;Infection;Inflammation;Injectable;innovation;Institution;Label;Measures;Metabolic;metabolic imaging;Methodology;migration;Monitor;multiphoton imaging;multiphoton microscopy;Mus;mutant;NADH;novel;novel therapeutic intervention;novel therapeutics;Oligonucleotides;Optics;Oxidation-Reduction;Patients;Pharmacodynamics;Population;porous hydrogel;Pre-Clinical Model;Predisposition;Process;Property;Proteins;Quality of life;repaired;Reporting;Research;Resistance;response;Signaling Protein;Site;skills;Skin wound healing;success;System;Testing;Therapeutic;Therapeutic Effect;tissue regeneration;tissue repair;Tissues;Treatment Efficacy;undergraduate student;Update;Variant;Vascularization;wound;wound care;wound dressing;wound environment;wound healing

PROJECT_TITLE: Hyperstable FGF1-FGF2 based therapeutic formulation for wound care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-X (81)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: NARRATIVE (OVERALL) The University of Michigan Rogel Cancer Center (Rogel) is committed to reducing cancer burden and improving cancer outcomes through research, innovation, transdisciplinary collaboration, education, and outreach. The Rogel vision is to be a leader in prevention, early diagnosis, optimal treatment and care for all at risk of or affected by cancer.

PI_NAMEs: FEARON, ERIC R. (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Abbreviations;Advanced Malignant Neoplasm;Advisory Committees;Affect;Animal Model;anti-cancer research;Appointment;Basic Science;Biological Sciences;Cancer Burden;Cancer Center;cancer clinical trial;Cancer Control;cancer education;cancer genetics;career;career development;Caring;Catchment Area;Cells;cellular imaging;Clinical;Clinical Research;Clinical Trials;Clinical Trials Support Unit;Collaborations;college;Communities;community advisory board;community center;community engagement;Community Outreach;Comprehensive Cancer Center;Data;Data Science;Development;Developmental Therapeutics Program;Direct Costs;Doctor of Philosophy;Drug Kinetics;Drug Screening;Early Diagnosis;Ecosystem;Education;Engineering;Epigenetic Process;epigenomics;equity, diversity, and inclusion;Faculty;Female;Financial Support;Flow Cytometry;Fostering;Funding;Gifts;Glossary;Grant;Growth;health communication;health equity;Health Policy;Hematopoiesis;Immunologic Monitoring;Immunology;improved;Infrastructure;innovation;Institution;inter-institutional;interdisciplinary collaboration;Intervention;Investments;irradiation;Journals;Justice;Leadership;liquid biopsy;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuscripts;medical schools;Medicine;member;Michigan;Mission;molecular imaging;molecular pathology;Names;National Cancer Institute;next generation;optimal treatments;Outcome;outreach;Patient Care;Patients;Population Sciences;pre-clinical;Prevention;Prevention program;programs;Proteomics;Public Health Schools;Publications;Publishing;Quality of life;Recording of previous events;recruit;Research;Resource Sharing;Resources;Risk;Role;Schools;Signal Transduction;Strategic Planning;Structure;Survivors;Tissue imaging;Tissues;Training;Training and Education;Transgenic Animals;Translational Research;translational research program;Translations;tumor microenvironment;United States National Institutes of Health;Universities;University of Michigan Comprehensive Cancer Center;Vision;Work

PROJECT_TITLE: Supplement to Enhance the Utility of Data Available through the Childhood Cancer Data Initiative (CCDI) Ecosystem

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases;Lung

ORG_CITY: STILLWATER

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: Public Health Relevance Statement: Cryptococcus neoformans is a fungal pathogen that is inhaled and subsequently causes life-threatening infections of the brain in immunocompromised individuals. The studies proposed in this application are designed to identify mechanisms of anti-fungal activity by components of the lysosome from dendritic cells and to test their therapeutic efficacy. We expect that these studies will ultimately lead to identification of novel therapies to treat fungal infections.

PI_NAMEs: WOZNIAK, KAREN LYNN (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Anabolism;Animals;anti-fungal agents;Binding;Biological Assay;Brain;Cell Culture Techniques;Cell membrane;Cell Membrane Permeability;Cell Shape;Cell Wall;Cells;Cellular Structures;Central Nervous System;Cessation of life;Collection;confocal imaging;Confocal Microscopy;Control Animal;coronin protein;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Cytolysis;Dendritic Cells;design;Disease;DNA purification;Drug Kinetics;efficacy testing;Ergosterol;experimental study;Flow Cytometry;Fungal Components;Fungal Genes;genome sequencing;graduate student;Human;Immune response;Immunocompromised Host;Immunologics;In Vitro;in vitro activity;in vivo;Individual;Infection;Inhalation;Laboratories;Leukocyte Elastase;Libraries;Life;Lung;lysosomal proteins;Lysosomes;Mammalian Cell;Membrane;Meningitis;Metalloproteins;Microscopy;mouse model;mutant;Mutation;Mycoses;novel;novel therapeutics;Organism;pathogen;pathogenic fungus;Pathway interactions;Peroxidases;Phagocytes;Pharmaceutical Preparations;prevent;Proteins;Public Health;public health relevance;Resistance;Resistance development;resistant strain;Scanning Electron Microscopy;screening;Shapes;Signal Pathway;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Time;Toxic effect;training opportunity;Transmission Electron Microscopy;Treatment Efficacy;undergraduate student;uptake;whole genome

PROJECT_TITLE: Mechanisms of Antifungal Activity of Dendritic Cell Lysosomal Proteins

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Congenital Structural Anomalies;Dietary Supplements;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Nutrition;Pediatric;Prevention

ORG_DEPT: NUTRITION

PHR: The goal of the current proposal is to determine how the zinc transporter protein ZIP12 is necessary for brain function and optimal brain development. Completion of the proposed studies will demonstrate how ZIP12 represents an example of how nutrients and genes interact to promote and maintain brain function during development. The knowledge gained from these studies may lead to nutritional or pharmacological strategies for preventing intellectual disabilities or neurodevelopmental disorders, particularly for individuals with genetic susceptibilities to nutritional deficiencies or related developmental disorders.

PI_NAMEs: CHOWANADISAI, WINYOO  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Address;Affect;Age;Alzheimer's Disease;American;Animal Model;Area;autism spectrum disorder;biobank;Brain;brain dysfunction;Bypass;Candidate Disease Gene;Cell membrane;Child;Clinical Trials;Cognitive deficits;cognitive function;cognitive performance;Consumption;Corpus striatum structure;Data;Development;developmental disease;Diagnosis;Diet;Diet and Nutrition;Dietary Intervention;Dietary Zinc;Education;Embryo;Embryonic Development;emerging adult;Ensure;Environment;Environmental Risk Factor;exome sequencing;experience;Experimental Models;Family;Food Interactions;Future;gene interaction;Genes;Genetic;genetic element;Genetic Polymorphism;Genetic Predisposition to Disease;genome wide association study;Goals;Homeostasis;Human;Human Genome;human model;impaired brain development;In Vitro;in vivo;Individual;Inherited;instrumentation;Intellectual functioning disability;Intervention;Investigation;Ionophores;Knockout Mice;Knowledge;Laboratories;Laboratory Research;Learning;Length;Life;Link;Magnetic Resonance Imaging;Malnutrition;Mammals;mathematical ability;Medicine;Membrane Transport Proteins;Memory;Metabolism;Minerals;model of autism spectrum disorder;Modeling;Molecular and Cellular Biology;mouse model;Mus;Mutation;Nervous System;nervous system development;Nervous System Physiology;Neural Tube Closure;Neural Tube Defects;neurobehavioral;Neurobiology;neurodevelopment;Neurodevelopmental Deficit;Neurodevelopmental Disorder;Neurologic Deficit;neuron development;Neurons;novel;Nutrient;nutrient metabolism;Nutritional;Nutritional Study;Oral;Outcome;Patient Self-Report;Pharmaceutical Preparations;pharmacologic;Positioning Attribute;postnatal;precision nutrition;prevent;Prevention;protein metabolism;Proteins;Rana;rare variant;Research;Research Design;Research Personnel;Risk;Risk Reduction;Role;screening;solute;Strategic Planning;Support Groups;Testing;Training;undergraduate research;undergraduate student;United States National Institutes of Health;uptake;Work;Xenopus;Zinc;Zinc deficiency;Zinc supplementation;zinc-binding protein;ZIP protein

PROJECT_TITLE: The Role of Mouse Zinc Transporter ZIP12 in Brain Development

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Antimicrobial Resistance;Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

PHR: Project Narrative Antibiotics represent the next global pandemic level threat as antimicrobial resistance is on a rapid rise and new antibiotic development is minimal; therefore, it is critical that the international community develop a sizeable and effective arsenal against bacterial infections. Development of novel antibiotics requires an intimate understanding of how conventional antibiotics function to inhibit bacterial growth. In this pursuit, this research aims to enhance our comprehension of a crucial stage in bacterial proteins synthesis, namely subunit joining, and explore the mechanisms through which conventional antibiotics specifically target and inhibit this process.

PI_NAMEs: GIRODAT, DYLAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Agriculture;Antibiotics;Antimicrobial Resistance;antimicrobial resistant pathogen;Bacterial Infections;Bacterial Proteins;Behavior;Binding;biophysical properties;Biophysics;Centers for Disease Control and Prevention (U.S.);Communication;Communities;Complex;Comprehension;Cryoelectron Microscopy;Data;design;Development;experimental study;Foundations;Free Energy;Goals;Growth;insight;International;Investigation;Kinetics;Knowledge;Light;Measures;Medicine;Modification;Molecular;Molecular Conformation;novel;Pactamycin;pandemic disease;pathogen;Pathogenicity;Play;prevent;Process;programs;Prokaryotic Cells;Protein Biosynthesis;Proteins;Publications;rational design;Readiness;Research;Research Project Grants;Ribosomes;Role;simulation;Solvents;Structure;Surface;Temperature;Tetracyclines;Thermodynamics;Translational Repression;Translations;undergraduate student;World Health Organization

PROJECT_TITLE: Understanding Mechanisms of Antibiotic Inhibition of Ribosomal Subunit Joining

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: CHARLOTTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE Chemotherapy induced peripheral neuropathies are painful sequelae of anti-cancer therapy, manifested by peripheral tingling, numbness, burning pain, and loss of balance. There are no therapeutics or treatment for chemotherapy induced peripheral neuropathy. This project investigates the neuroprotective role of a newly identified FDA approved drug, Fluocinolone acetonide, in Paclitaxel induced peripheral neuropathy.

PI_NAMEs: YANG, IN HONG  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;Afferent Neurons;Affinity;anti-cancer;Antineoplastic Agents;Axon;axon growth;axon regeneration;axonal degeneration;Axonal Transport;Biogenesis;Bladder;Breast;Burning Pain;cancer therapy;Cell membrane;Cells;chemotherapy;Chemotherapy-induced peripheral neuropathy;Chemotherapy-Oncologic Procedure;Clinical;Complement;Data;design;Development;Distal;Distress;dosage;Dose Limiting;Drug Screening;Drug Utilization;Endoplasmic Reticulum;Energy Supply;Engineering;Equilibrium;Esophagus;Event;experience;FDA approved;Female;Fluocinolone Acetonide;foot;Functional disorder;Functional impairment;Glucocorticoid Receptor;Glucocorticoids;Golgi Apparatus;Growth Cones;Hand;Health;high-throughput drug screening;Homeostasis;imaging modality;In Vitro;in vivo;Incidence;innovation;Interdisciplinary Study;Intervention;Ion Channel;Label;Lysosomes;Malignant Neoplasms;Mediating;Methods;Microfluidics;Mitochondria;Movement;Neurons;neuroprotection;Neuroprotective Agents;Neurosciences;Non-Small-Cell Lung Carcinoma;North Carolina;Numbness;Organelles;Ovarian;Paclitaxel;Pain;pain sensation;painful neuropathy;Pathogenesis;Patients;Peripheral;Peripheral Nervous System Diseases;Pharmaceutical Preparations;pharmacologic;Play;Population;Positioning Attribute;prevent;Production;Prostate;Publications;Quality of life;receptor;recruit;Reporting;Research;research and development;Research Project Grants;retrograde transport;Role;Sampling;side effect;Signal Pathway;Signal Transduction;Skin;Spatial Distribution;Students;Symptoms;System;Therapeutic;therapeutic candidate;Time;trafficking;treatment effect;undergraduate student;Underrepresented Minority;Universities

PROJECT_TITLE: Neuroprotection for chemotherapy induced peripheral neuropathy

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Hearing Loss;Neurosciences;Regenerative Medicine

ORG_CITY: STANFORD

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE This research project aims to unravel the mechanisms underlying the quiescent and non-regenerative nature of cochlear supporting cells in adult mice, shedding light on their molecular and epigenetic signatures. Through a comprehensive characterization of these cells under both normal and damage-induced conditions, this study will provide critical insights into the barriers that impede their ability to re-enter the cell cycle and regenerate hair cells. By leveraging these insights, the project aims to develop innovative therapeutic strategies that can effectively restore hearing in humans, aligning with the NIH's mission to alleviate the burden of human illness and disability.

PI_NAMEs: BENKAFADAR, NESRINE  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: activating transcription factor 3;Acute;Address;adeno-associated viral vector;Adult;Advanced Development;Affect;aged;ATAC-seq;Attenuated;Auditory;Auditory system;Birds;Cell Cycle;Cell Death;cell fate specification;cell injury;Cell Proliferation;Cells;Chickens;Chronic;Cochlea;comparative;Data;Data Analyses;Data Set;deaf;Dependovirus;Development;disability;effective therapy;Effectiveness;Employment;Ensure;Epidermal Growth Factor Receptor;Epigenetic Process;FOSL2 gene;Gene Delivery;Gene Expression;Gene Transfer;Genes;Genetic Transcription;Goals;hair cell regeneration;Hair Cells;Hearing;hearing impairment;hearing loss treatment;hearing restoration;Human;Individual;inducible gene expression;Injections;Inner Hair Cells;innovation;insight;Light;Long-Term Effects;Mammals;MAP Kinase Gene;Matrix Metalloproteinases;Measures;Mediating;Methods;Mission;Modeling;Molecular;Molecular Profiling;mRNA Expression;multiple omics;Mus;MYO7A gene;Natural regeneration;Nature;neonatal mice;novel therapeutics;Organ of Corti;Outcomes Research;Outer Hair Cells;Pathway interactions;Patients;permissiveness;pharmacologic;prevent;Proliferating;Proliferation Marker;promoter;rat Pres protein;Recombinant adeno-associated virus (rAAV);Recovery;regeneration potential;regenerative;Regenerative capacity;Regenerative pathway;Regenerative response;regenerative therapy;Research;Research Project Grants;Resolution;S phase;Sensory Hair;Signaling Protein;single nucleus RNA-sequencing;single-cell RNA sequencing;Specific qualifier value;Stat3 Signaling Pathway;Statistical Methods;Supporting Cell;targeted treatment;Techniques;Therapeutic;therapeutic candidate;Therapeutic Intervention;therapy development;Time;transcription factor;transcriptomics;United States National Institutes of Health;Viral Vector;Virus;World Health Organization

PROJECT_TITLE: Avian-inspired Regenerative Therapies for Hearing Loss

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Y (58)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_DEPT: PATHOLOGY

PHR: Project Narrative: Testing drugs to see if they increase healthy lifespan in genetically heterogeneous mice is an effective way to find interventions that may alter human aging, because these mice are good models for the clinic, and give reasonably rapid and reliable results, especially when used in three different sites. Identification of interventions that retard aging will suggest research directions leading to clinical treatments designed to prevent or retard deleterious changes with age.

PI_NAMEs: MILLER, RICHARD A (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: Acarbose;Adult;Age;age related;age related changes;Aging;aging mechanism;anti aging;Application procedure;astaxanthine;Beds;Biological Specimen Banks;Biology of Aging;Brain;Captopril;Cause of Death;Clinic;Clinical Treatment;Collaborations;Communities;comparative;Data;Data Coordinating Center;data management;Data Pooling;Data Set;Diagnostic Specificity;Disease;Dose;Drug Kinetics;drug testing;Elements;end of life;Estradiol;Evaluation;experimental study;extend lifespan;Fatty acid glycerol esters;Gene Expression;Glycine;Goals;Health;healthspan;Histopathology;Human;insight;interest;International;Intervention;intervention effect;Laboratories;late life;Learning;life span;Link;Liver;Longevity;Mammals;meetings;member;Memory;Michigan;middle age;Modeling;Molecular;Mus;Muscle;New Agents;Organ;Outcome;Output;Pathologic;Pathology;Pharmaceutical Preparations;Physiological;Plasma;preservation;prevent;Procedures;programs;Protocols documentation;Publications;rate of aging;Reliability of Results;Reproducibility;Research;response;Schedule;Scientist;sex;Sirolimus;Site;Specific qualifier value;Specimen;Standardization;Testing;Texas;therapy design;tissue archive;tissue preparation;Tissues;Transcript;transcriptome sequencing;transcriptomics;transmission process;Universities;web site;Work

PROJECT_TITLE: Interventions Testing Program at UM

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (J1)]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Nutrition;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: STRATFORD

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED

ORG_STATE: NJ

PHR: Project Narrative Since most Traumatic Brain Injury (TBI) drug trials have failed, medical intervention options for long-term TBI survivors with chronic TBI and cerebrovascular disease (CVD) are limited. Since a considerable number of research articles highlighting the neuroprotective and anti-inflammatory effects of various diets have been published, we are proposing to study the beneficial effects of a low-fat, high-fiber diet (LFHFD) over high-fat and cholesterol, and low-in-fiber (standard western diet, WD) in an American Heart Association recommended mouse model with chronic CVD and TBI. We will study the impact of these two diets in reinstating BBB integrity and reducing neuroinflammatory and systemic immune responses.

PI_NAMEs: ACHARYA, NIMISH KUMAR (contact)

PROJECT_TERMS: Adoption;Aging;Albumins;American;American Heart Association;Animals;Antibodies;Antiinflammatory Effect;Biological Assay;Biological Response Modifiers;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood specimen;Blood Vessels;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain parenchyma;Cardiovascular Diseases;cardiovascular effects;cardiovascular health;Cardiovascular Manifestation;Cardiovascular Models;cardiovascular risk factor;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;Cholesterol;Chronic;Clinical;cognitive change;cohort;comorbidity;controlled cortical impact;Craniotomy;Data;Data Collection;Dementia;Diet;Doctor of Philosophy;drug testing;early detection biomarkers;Elderly;endophenotype;epidemiology study;Euthanasia;evidence base;Experimental Designs;Extravasation;Failure;Fatty acid glycerol esters;Fiber;Framingham Heart Study;Funding Mechanisms;Future;Gene Expression;Gliosis;Goals;Guidelines;high-fat/low-fiber diet;Human;Immune response;Immunoglobulin G;Immunohistochemistry;Impaired cognition;Incidence;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Inflammatory Response;Injury;International;interstitial;Intervention;Investments;Knockout Mice;Leukocytes;Life;Long term disability;Low Density Lipoprotein Receptor;Manuscripts;Medical;meetings;microvascular pathology;migration;modifiable risk;Monitor;mouse model;Mus;Nerve Degeneration;neuroinflammation;Neurologic;neuropathology;neuroprotection;nutrition;Nutritional Study;offspring;Outcome;Palliative Care;Paraffin Embedding;Pathology;Pharmaceutical Preparations;Pilot Projects;Polymerase Chain Reaction;Pre-Clinical Model;prevent;Process;protein expression;Publications;Publishing;Recommendation;Reporting;Research;Risk Factors;risk minimization;Role;Running;Sampling;Secondary to;Serum;Serum Albumin;Severities;Strategic Planning;Students;Survivors;Testing;Time;tissue processing;Traumatic Brain Injury;United States National Institutes of Health;uptake;Western Blotting;western diet;Writing;young adult

PROJECT_TITLE: Investigating the potential impact of a low-fat high fiber diet in limiting TBI-induced neurodegenerative and inflammatory changes.


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Liver Disease;Microbiome;Organ Transplantation;Prevention;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The overall goals of this program are to provide an outstanding training program in mentored patient-oriented research in antimicrobial resistance and microbial genomics by examining the gut microbiome is a reservoir for antibiotic resistance, as well as for pathobionts that can cause non-infectious chronic disease complications. This will be achieved through rigorous projects that will assess microbial factors that predict colonization and clearance of MDROs and progression to systemic infection and non-infectious complications such as rejection, taking advantage of high-resolution sequencing data. We will use rigorous machine learning analysis to obtain a detailed understanding of gut microbiome risk factors, which will inform predictive risk management algorithms to aid in critical clinical decision-making for MDRO colonization in high-risk patients.

PI_NAMEs: UHLEMANN, ANNE-CATRIN  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acute;Address;Affect;Age;Algorithms;allograft rejection;Animals;Antibiotic Resistance;Antibiotic Therapy;Antimicrobial Resistance;Area;Articulation;Bacteria;Bacteriophages;Bile Acids;biobank;Biological Markers;biomarker identification;Biopsy;carbapenem resistant Enterobacterales;carbapenem-resistant Enterobacteriaceae;career development;Case/Control Studies;Characteristics;Chronic Disease;Clinical;Clinical Data;clinical decision-making;Clinical Management;cohort;Communicable Diseases;Complex;Containment;Data;data integration;Data Set;Diagnostic;Discipline;Drug resistance;dysbiosis;emerging antimicrobial resistance;empowerment;Epidemiology;Etiology;Evolution;Future;genome sequencing;Genomics;Goals;Grant;Growth;gut colonization;gut dysbiosis;gut inflammation;gut microbiome;Health;Health care facility;high risk;Hospitals;Human;Immune system;immunogenic;Individual;Infection;infection risk;innovation;insight;Institution;interest;Intervention;Intestines;Klebsiella pneumoniae;Laboratories;Link;Liver;Liver diseases;liver inflammation;liver transplantation;longitudinal analysis;Longitudinal cohort;Machine Learning;machine learning prediction;Measures;meetings;Mentors;metagenome;metagenomic sequencing;Metagenomics;microbial;microbial community;Microbial Drug Resistance;microbial genomics;microbiome;microbiota;Molecular Epidemiology;Morbidity - disease rate;mortality;multi-drug resistant pathogen;Nested Case-Control Study;next generation;next generation sequencing;novel;novel diagnostics;novel strategies;novel therapeutics;organ transplant recipient;Outcome;pathobiont;pathogen;patient oriented;patient oriented research;patient population;Patients;Population;Positioning Attribute;post-transplant;potential biomarker;Predictive Factor;prevent;Production;programs;Property;Prophylactic treatment;Public Health;Publishing;Recurrence;Research;research and development;Research Personnel;Research Project Grants;resistance gene;Resolution;Resources;Risk;Risk Factors;Risk Management;risk prediction;Role;Sampling;skills;Solid;stool sample;Systemic infection;T-Cell Activation;Therapeutic;therapeutic target;tool;Training;training opportunity;Training Programs;translational impact;transmission process;Transplant Recipients;Transplantation;Transplanted Liver Complication;treatment response;Urinary tract infection;Virulence;Volatile Fatty Acids;whole genome;Work;World Health Organization

PROJECT_TITLE: Mentoring program in patient-oriented research in microbial genomics

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Mental Health;Mental Illness;Neurosciences;Women's Health Research

ORG_CITY: JAMAICA

ORG_NAME: YORK COLLEGE

PHR: Project Narrative Stress and anxiety disorders such as PTSD and phobia are a significant public health problem, with current intervention strategies for these disorders showing limited efficacy. Substantial research suggests diminished capacity to extinguish conditioned fear plays an important role in the development and treatment of these disorders. This proposal will advance scientific understanding of fear-related disorders, and enhance student training, by studying how states of anxious anticipation, trait vulnerability to threat, and biological sex can interact to shape fear extinction learning across behavioral, neurobiological and psychophysiological levels.

PI_NAMEs: JOHNSON, DAVID CHARLES (contact)

PROJECT_TERMS: Acute;Address;Aftercare;alpha-amylase;Animals;Anxiety;Anxiety Disorders;anxious;Arousal and Regulatory Systems;Attenuated;Behavioral;biological adaptation to stress;biological sex;Brain;Clinical;Cognitive Therapy;college;conditioned fear;Data;Development;differential expression;Dimensions;disadvantaged background;Disease;Disease susceptibility;Disparity;Equilibrium;Estrogens;Extinction;Failure;Female;Fright;Galvanic Skin Response;Glucocorticoids;Goals;Gonadal Steroid Hormones;Human;Hydrocortisone;improved;indexing;Individual;Individual Differences;individual variation;interest;Intervention;knowledge base;Learning;learning extinction;Link;male;Measures;Mediating;Mediator;Mental disorders;Mission;Modeling;Muscle;Nature;Negative Valence;Neurobiology;Neurosecretory Systems;Nonpharmacologic Therapy;noradrenergic;novel;Outcome;Performance;personalized medicine;Phobias;Physiological;Play;Post-Traumatic Stress Disorders;Predisposition;Prevalence;Process;Progesterone;Psychophysiology;Public Health;Regulation;Research;Research Domain Criteria;response;Retrieval;Role;Salivary;Science;Scientific Advances and Accomplishments;Scientific Inquiry;self-reported anxiety;sex;Sex Differences;Shapes;Stimulus;Strategic Planning;Stress;stress disorder;stress reactivity;Stressful Event;student training;System;Testing;Therapeutic Intervention;training opportunity;trait;Treatment outcome;Uncertainty;undergraduate student;Underrepresented Minority;Underrepresented Students;United States National Institutes of Health;Update;women versus men;Work

PROJECT_TITLE: The effects of biological sex, intolerance of uncertainty and anxious states on threat acquisition and extinction learning


NIH_SPENDING_CATS: Brain Disorders;Data Science;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Networking and Information Technology R&D (NITRD)

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE. The mission of the NIH INCLUDE Project is to accelerate research that addresses the critical health and quality of life needs of individuals with Down syndrome (DS). In order to increase diversity in the pool of young DS researchers, this project will support a training program in data sciences for historically under-represented minorities (URMs) known as the Data Science for Diverse Scholars in Down Syndrome Research (DS3). which will provide training in the basics of generation, identification, and collection of high-content multidimensional datasets; their management, analysis, and visualization; as well as the development of key professional skills required for the career advancement of diverse trainees.

PI_NAMEs: ESPINOSA, JOAQUIN M. (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Acceleration;Address;Administrative Supplement;Advocate;analytical tool;big data management;Bioinformatics;Biometry;career;Career Mobility;Case Study;Clinical;Clinical Data;Clinical Research;cloud based;cluster computing;Code;Collection;Colorado;Common Data Element;Communities;Data;Data Analyses;Data Coordinating Center;data hub;Data Science;Data Set;data visualization;Development;Dimensions;Discipline;Down's Syndrome;Educational Curriculum;Educational process of instructing;Educational workshop;empowerment;Ensure;Environment;equity, diversity, and inclusion;Event;Faculty;FAIR principles;Feedback;Funding;Future;General Population;Generations;Genome;graduate student;Grant;Health;High Performance Computing;Human;Individual;Learning;Libraries;Linux;literacy;Medical;metabolomics;Metadata;Minority;Mission;multidimensional data;multidisciplinary;next generation sequencing;Ontology;outreach;Persons;Population Scientist Supplement (R25);Postdoctoral Fellow;Proteomics;public repository;Pythons;Quality of life;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Research Training;Resources;responsible research conduct;skills;Slide;student training;Students;teacher community;tool;Training;Training Programs;transcriptome;tutoring;Underrepresented Minority;United States National Institutes of Health;Universities;Visualization;web site;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (56)]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Gene Therapy;Genetics;Immunotherapy;Natural Products;Skin Cancer

ORG_CITY: BATON ROUGE

ORG_NAME: SOUTHERN UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project narrative Malignant cutaneous melanoma is the most lethal form of all skin cancers, causing approximately 10,000 deaths annually in the United States. Here we hypothesize that local inhibition of the PI3K/AKT/mTOR signaling pathway in the tumors will create an optimal condition for the intratumoral spread of the oncolytic virus and virus-induced cancer cell death. Currently, advanced melanoma patients have limited treatment options; thus, this project will address a critical unmet need for more effective therapies.

PI_NAMEs: CHAMCHEU, JEAN CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Adverse effects;AKT inhibition;analog;Animal Model;Anti-viral Response;Apoptosis;Biological;Biomedical Research;biomedical scientist;cancer cell;Cancer Etiology;cancer therapy;cancer type;carcinogenesis;career;catalyst;Cell Cycle;Cell Death;Cell Line;cell type;Cells;Cellular Stress;Cessation of life;chemotherapy;college;Combined Modality Therapy;Communication;Competitive Binding;conventional therapy;cost;Cutaneous Melanoma;cytotoxicity;Data;design;Development;Disease;Disease Management;Dose;Education;effective therapy;effectiveness evaluation;efficacy evaluation;emerging virus;Engineering;Ensure;env Gene Products;Environment;Equilibrium;Female;fisetin;FRAP1 gene;Funding;G-substrate;glycoprotein G;Human;human disease;Hybrids;Immune response;Immunotherapy;improved;In Vitro;in vitro Assay;in vivo;Incidence;Infection;Inflammatory Response;Infrastructure;inhibitor;innovation;insight;Institution;Interferon Type I;Interferons;Investigation;Malignant - descriptor;Malignant Neoplasms;Measures;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;Metastatic Melanoma;Methods;Modeling;mortality;mouse model;mTOR inhibition;mTOR Inhibitor;mTOR Signaling Pathway;multimodality;Mus;Natural Compound;neoplastic cell;Normal Cell;novel;novel therapeutic intervention;Oncology;Oncolytic;oncolytic Vesicular Stomatitis Virus;oncolytic virotherapy;Oncolytic viruses;Outcome;Pathway interactions;Patient-Focused Outcomes;Pharmaceutical Preparations;pharmacologic;Pharmacy facility;Phosphotransferases;PI3K/AKT;PIK3CG gene;pre-clinical;preclinical efficacy;preclinical safety;Productivity;Protein Biosynthesis;Proto-Oncogene Proteins c-akt;prototype;Public Health;resilience;Resistance;response;Rhabdoviridae;RNA;RNA Viruses;Role;Safety;Signal Pathway;Signal Transduction;skills;Skin Cancer;small molecule;small molecule inhibitor;stem;Students;Survival Rate;Systemic Therapy;Testing;Therapeutic;Treatment Efficacy;tumor;tumor growth;tumorigenesis;undergraduate student;Underrepresented Minority;United States;Vaccines;Vesicular stomatitis Indiana virus;Viral;Virotherapy;Virus;virus related cancer;Work

PROJECT_TITLE: Harnessing the potential of pharmacological small molecules to amplify VSV-based oncolytic viral therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-J (80)]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer

ORG_CITY: SPEARFISH

ORG_NAME: BLACK HILLS STATE UNIVERSITY

ORG_STATE: SD

PHR: PROJECT NARRATIVE Neddylation has been validated as a target for cancer therapy, and the inhibition of the Nedd8 E1 enzyme has the potential to serve as an effective treatment for cancer, particularly for solid tumors. By utilizing a validated sensor to monitor free Nedd8, we can conduct direct assays to identify small molecules that block neddylation, a process that should be adaptable for high-throughput drug screening formats. Following the identification of potential drug candidates, our sensors for live cells can be employed in a second round of screening via a cell- based assay. As such, the proposed research aligns with the part of the NIH mission that is committed to reducing illness and disability.

PI_NAMEs: CHOI, YUN SEOK  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Affect;Affinity;Binding;Biochemistry;Biological;Biological Assay;Biological Markers;Biology;Biomedical Research;Biosensor;cancer therapy;career;cell growth regulation;Cells;Cellular Stress;Creativeness;Cullin Proteins;Data;design;Development;disability;drug candidate;drug discovery;effective therapy;Engineering;Environment;enzyme pathway;enzyme reconstitution;Enzymes;experience;experimental study;flexibility;Fluorescence;Fluorescence Resonance Energy Transfer;Generations;Goals;HCT116 Cells;high-throughput drug screening;improved;In Vitro;inhibitor;innovation;Kinetics;Knowledge;Length;Ligands;Luciferases;luminescence;Malignant Neoplasms;Mammalian Cell;Measurement;Measures;Mission;Modeling;Molecular Biology;Monitor;nanoluciferase;novel;Pathway interactions;Peptides;Pharmaceutical Preparations;Preparation;prevent;Process;Production;Proteins;Reaction;Reporter;Reproducibility;Research;Research Proposals;screening;sensor;Signal Transduction;Site-Directed Mutagenesis;small molecule;Solid Neoplasm;structural determinants;Structure;Students;targeted cancer therapy;targeted treatment;Testing;Tissues;tool;Training;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;undergraduate student;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: A design strategy to quantify unconjugated Nedd8 using genetically encoded sensors.

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


ORG_CITY: LAS CRUCES

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: Project Narrative: The NM-INBRE program provides research, training, and career development opportunities for early-career faculty and students at all levels of education. We deliver innovative biomedical research that contributes to improving human health, especially to underserved populations in New Mexico.

PI_NAMEs: LUSETTI, SHELLEY  (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Achievement;Address;Alaska;Award;base;Benchmarking;Biomedical Research;career;career development;Career Mobility;Centers of Research Excellence;Cloud Computing;Collaborations;college;Communication;Communities;community based research;community college;computing resources;Consultations;Data Science;Development;early-career faculty;economic disparity;Education;Educational Status;Educational workshop;Environment;Equipment;experience;Faculty;faculty research;faculty support;forging;Fostering;Funding;genome resource;Grant;Hawaii;Health;Health Sciences;higher education;Human;Idaho;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;Knowledge;Lead;Leadership;Measures;medically underserved;Medicine;meetings;Mentors;Mentorship;Mining;Minority;Minority-Serving Institution;Montana;National Institute of General Medical Sciences;Native Americans;Nevada;New Mexico;organizational structure;Population;Process;Productivity;programs;Publications;Quality of life;Research;research and development;Research Infrastructure;Research Personnel;Role;Route;Rural;rural area;rural underserved;Services;student participation;Student Persistence;student training;Students;summer research;symposium;Teacher Professional Development;Technology;Training;Training and Infrastructure;tribal community;undergraduate research experience;undergraduate student;underserved community;Underserved Population;United States National Institutes of Health;Universities;Wyoming

PROJECT_TITLE: New Mexico IDeA Networks of Biomedical Research Excellence (INBRE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-7 (IN)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science

PROJECT_TERMS: Achievement;Award;base;Biomedical Research;career;career development;Centers of Research Excellence;Cloud Computing;cohort;college;Communication;Communities;community based research;community college;Complement;computing resources;Consultations;Core Facility;Data Science;Data Science Core;Development;economic disparity;Educational Status;Educational workshop;Environment;Equipment;Evaluation;evidence base;experience;Faculty;faculty mentor;faculty research;faculty support;Fostering;Funding;Funding Opportunities;genome resource;Government;Grant;Health;Health Sciences;higher education;improved;Infrastructure;Institution;Interdisciplinary Study;Knowledge;Lead;Leadership;Life Style;Measures;Medicine;Mentors;Mentorship;Mexican;Mining;Minority;Minority-Serving Institution;New Mexico;operation;organizational structure;Outcome;Population;Principal Investigator;Process;Productivity;Program Evaluation;Program Research Project Grants;programs;Publications;Reduce health disparities;Research;research and development;Research Personnel;Research Project Grants;Research Support;Research Training;Role;rural area;Services;student participation;student training;Students;success;summer research;symposium;Technology;Training;tribal community;undergraduate student;Universities

PROJECT_TITLE: NM-INBRE Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: GARD, CHARLOTTE C. (contact)

PROJECT_TERMS: Acceleration;Achievement;Alaska;Artificial Intelligence;Award;bioinformatics tool;biological research;biomedical data science;Biomedical Research;career;Centers of Research Excellence;Cloud Computing;Collaborations;college;community based research;community college;computing resources;Consultations;Creativeness;Data;data integration;Data Science;Data Science Core;data science education;data science resource;Data Scientist;Data Set;Development;economic disparity;Education;Educational Curriculum;Educational Status;Educational workshop;Ensure;Environment;experience;Faculty;faculty research;faculty support;field study;Funding;genome resource;Genomics;graduate student;Grant;Hawaii;Health;Health Sciences;higher education;Human Resources;Idaho;improved;Infrastructure;Institution;Interdisciplinary Study;Internships;Knowledge;Lead;Machine Learning;Medicine;member;Mentors;Mentorship;Mining;Minority;Minority-Serving Institution;Montana;Nevada;New Mexico;organizational structure;outreach;Participant;Population;Postdoctoral Fellow;Process;programs;Proteomics;Publications;Quality of life;Research;research and development;research faculty;Research Personnel;Research Training;Role;Route;rural area;Scientist;Services;Statistical Data Interpretation;student training;Students;symposium;Techniques;Technology;tool;Training;Training and Education;training opportunity;transcriptomics;tribal community;undergraduate student;Universities;Wyoming

PROJECT_TITLE: Data Science Core (DSC)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Achievement;Acoustics;Animals;Biology;Biomedical Research;biosafety level 2 facility;career;Cell Culture Techniques;Cells;Cellular biology;Centers of Research Excellence;Cloud Computing;college;Communities;community based research;community college;computing resources;Consultations;Data Science;design;Development;economic disparity;Educational Curriculum;Educational process of instructing;Environment;Equipment;experience;experimental study;Face;Faculty;faculty research;faculty support;First Generation College Students;Fishes;Floor;Funding;genome resource;Goals;Grant;Health;Health Sciences;high school;higher education;Hispanic;Home;IACUC;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;Laboratories;laboratory equipment;laboratory facility;Laboratory Research;Latinx;Lead;Lighting;Mammalian Cell;Medicine;Mentors;Mentorship;Methods;Mining;Minority;Minority-Serving Institution;Modernization;Molecular;Molecular Biology;Native Americans;New Mexico;organizational structure;outreach;Pathway interactions;Play;Population;Poverty;Power Sources;Process;programs;Publications;Research;Research Activity;Research Personnel;Role;Route;rural area;Sampling;Secure;Services;skills;student training;Students;Talents;Technology;Training;tribal community;undergraduate research experience;undergraduate student;underserved students;United States National Institutes of Health;Universities;user protection;Vertebral column;Work

PROJECT_TITLE: Alterations and Renovations


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: LOS ANGELES

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE No protocol exists for use of living children’s DNA to reunify families separated due to disasters, armed conflict, or migration, despite DNA data being a powerful biometric tool for determining both identity and kinship that meets the needs of pre-verbal children to facilitate safe and prompt reunification of families. This study examines the existing and historic scenarios in which DNA data are or have been used in humanitarian contexts involving children and incorporates key voices to inform a consent protocol for children’s DNA use for reunification. Project findings will guide deeper research on best practices for children’s DNA data use and can immediately inform protocols and policies vital to structuring an ethically sound DNA reunification response that can be activated quickly so that no child remains needlessly separated because they cannot be identified.

PI_NAMEs: BARNERT, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: STERLING, RENE

PROJECT_TERMS: 12 year old;17 year old;Address;Affect;Age;Ally;Argentina;Benefits and Risks;Biometry;Caring;Child;Child Development;Child Health;Complement;Conflict (Psychology);Consensus;Consent;Data;data management;Data Protection;Delphi Study;Development;Disasters;DNA;DNA Databases;early childhood;El Salvador;Ensure;Equity;Ethics;Event;Family;family genetics;Family member;Future;Goals;Hurricane;implementation study;infancy;informant;Informed Consent;Infrastructure;innovation;insight;interest;Intervention;Interview;Investigation;Learning;Life Cycle Stages;Methodology;migration;Natural Disasters;Outcome;Parent-Child Relations;Parents;Participant;Personal Satisfaction;Policies;Process;Protocols documentation;Research;response;Risk;Role;Russia;Sampling;Secure;sound;Structure;symposium;Technology;Testing;tool;Trauma;Trust;verbal;virtual;visual map;Visualization;Voice;War;Work

PROJECT_TITLE: Developing strategies for using DNA data to assist family reunifications across child development stages

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Prostate cancer becomes an incurable lethal disease once it progresses to an advanced castration resistant state; however, despite the imperative clinical need, the biological and molecular mechanisms contributing to this lethal state remain unresolved. Our proposed studies using patient datasets, together with in vitro and in vivo patient-derived models will uncover transcriptional and translational mechanisms that contribute to lethal prostate cancer pathobiology. The molecular dissection of these mechanisms has the potential to generate new combined therapeutic strategies to improve prostate cancer patients’ clinical outcomes.

PI_NAMEs: DOMINGO-DOMENECH, JOSEP MARIA (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: androgen deprivation therapy;Androgen Receptor;AR gene;Automobile Driving;Biological;Biological Assay;cancer cell;Cancer Patient;Candidate Disease Gene;Castration;Categories;Cells;Clinical;clinical efficacy;clinically relevant;clinically significant;Combination Drug Therapy;Complex;computer studies;Coupled;Data;Data Set;Development;Disease;Dissection;efficacy evaluation;enzalutamide;Epigenetic Process;Eukaryotic Initiation Factors;Experimental Models;falls;functional genomics;gene network;gene repression;Genes;Genetic study;Genetic Transcription;Genomic approach;genomic platform;Growth;Growth Factor;Growth Factor Receptors;Human;improved;In Vitro;in vivo;in vivo evaluation;Individual;insight;Laboratories;Link;Luciferases;Male Castration;Malignant neoplasm of prostate;Malignant Neoplasms;melanocyte;Melanoma;Messenger RNA;microphthalmia-associated transcription factor;Modeling;Molecular;Molecular Abnormality;Mus;Mutagenesis;MYC gene;Neoplasm Circulating Cells;neoplastic cell;novel;novel drug combination;Nuclear;Oncogenes;Oncogenic;Oncoproteins;Organ;Organoids;Outcome;Pathogenesis;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Play;Pre-Clinical Model;Process;programs;Prokaryotic Initiation Factor-3;Proliferating;promoter;Property;Prostate;prostate cancer model;Prostatic Diseases;Prostatic Neoplasms;Protein Biosynthesis;protein expression;Protein Isoforms;Protein Synthesis Inhibition;Proteomics;PTEN gene;public database;RB1 gene;Recurrent disease;Regulation;Reporter;Research Proposals;Resistance;Ribavirin;Ribosomes;Role;Signal Pathway;Signal Transduction;SOX12 gene;Testing;Therapeutic;therapy resistant;Tissue Sample;TP53 gene;transcription factor;Transcriptional Regulation;transcriptomics;Translating;Translation Initiation;translational impact;Translational Regulation;Translations;tumor;Tumor Biology;Tumor Cell Biology;Tumor Suppressor Proteins;Work;Xenograft Model

PROJECT_TITLE: Determine the Microphthalmia Transcription Factor (MITF)-regulated cell rewiring mechanisms in lethal prostate cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_CITY: College Station

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: PROJECT NARRATIVE This project will address fundamental questions relevant to enteric calicivirus host interactions, focusing on the recently identified entry receptor and other determinants of susceptibility, and the mechanism of infection in polarized epithelia. Findings with our novel rhesus enteric calicivirus (ReCV) model will be evaluated for human norovirus (HuNoV) infections in the B cell and enteroid culture systems.

PI_NAMEs: FARKAS, TIBOR  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;adenovirus receptor;antigen binding;Apical;B-Lymphocytes;Bile fluid;bile salts;Binding Sites;Biodiversity;Biological;Biological Models;Biopsy;Blood Group Antigens;Calicivirus;Calicivirus Infections;Cell Culture System;Cell Culture Techniques;Cell Line;Cell surface;Cessation of life;comparative;Consumption;Coxsackie Viruses;CRISPR/Cas technology;cross-species transmission;Data;Development;Diarrhea;Disease;Enteral;enteric virus infection;Enterobacter;Enterocytes;Environment;Epithelium;Exhibits;Extracellular Domain;Fever;Gastroenteritis;Genetic;genome wide screen;glycosylation;Goals;Healthcare;Hospitalization;Human;improved;In Vitro;infected B cell;Infection;insight;Integration Host Factors;Intervention;intestinal epithelium;Intestines;Laboratories;Lamina Propria;M cell;Macaca;Maps;Mediating;Membrane;Modeling;monolayer;mutant;nonhuman primate;Norovirus;novel;Pathway interactions;Peripheral Blood Mononuclear Cell;permissiveness;Play;polarized cell;Positioning Attribute;Predisposition;Prevention strategy;Primates;Protein Isoforms;Public Health;receptor;Reproducibility;Research;Rhesus;Role;Serotyping;Site;societal costs;Surface;System;Testing;Tight Junctions;Time;United States;Viral;Virus;Work;Zoonoses

PROJECT_TITLE: Determinants of Enteric Calicivirus Infection.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-X(02)M]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: Project Narrative The mission of the Mayo Clinic Medical Scientist Training Program (MSTP) is to train clinician-scientist (MD- PhD) leaders of the future. Our program is designed to mentor a diverse group of trainees whom we individually guide on their journeys to develop the technical, operational, and professional skills to support a life-long productive career in which they integrate research and clinical activities to advance biomedical science.

PI_NAMEs: KAUFMANN, SCOTT H;SCHIMMENTI, LISA A (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Clinic

PROJECT_TITLE: MSTP at Mayo Clinic Rochester

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Narrative  We propose to develop and validate a clinical sample–based strategy for influenza vaccine strain selection and to study molecular mechanisms for antigenic evolution of influenza viruses; study findings will lead to significant technologic advances in influenza prevention and control and contribute fundamental knowledge regarding influenza virus evolution.

PI_NAMEs: WAN, XIUFENG HENRY (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Affect;Affinity;Age;Antibodies;Antigenic Variation;Antigens;Binding;Biological Assay;Cell Culture Techniques;Cells;Clinical;cohort;cross reactivity;Data;Disease Outbreaks;egg;Epidemiologic Factors;Evolution;exposed human population;Exposure to;Ferrets;Genetic Polymorphism;Genome;Genomics;Genotype;Goals;high throughput technology;Human;Immunity;Immunization Programs;Immunologics;Infection;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;influenza outbreak;Influenza prevention;influenza surveillance;Influenza vaccination;influenza virus vaccine;influenzavirus;Knowledge;learning strategy;Letters;Ligation;Methods;Modeling;Molecular;Molecular Evolution;Mutation;nasopharyngeal swab;National Institute of Allergy and Infectious Disease;Natural History;next generation;novel;pandemic disease;polyclonal antibody;Property;Recording of previous events;response;Sampling;Seasons;Serology;Serology test;Serum;sex;Specificity;Strategic Planning;Swab;Technology;Testing;Time;transcriptome sequencing;universal influenza vaccine;Vaccination;vaccine effectiveness;Vaccines;Variant;Virus;virus testing

PROJECT_TITLE: Use of Clinical Samples to Identify Influenza Virus Antigenic Variants

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ORG_DEPT: ANESTHESIOLOGY

PHR: Narrative The proposed program will provide support for postgraduate research training in the Department of Anesthesiology within the Health Sciences Division of Columbia University to qualified applicants who have committed to or are enrolled in postgraduate training in anesthesiology. The goal of this training is to provide for the next generation of physician-scientists and researchers who will seek to improve medical care in areas relevant to perioperative care, palliative care, acute and chronic pain, and health services delivery.

PI_NAMEs: EMALA, CHARLES W (contact);HUA, MAY

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Anesthesiology;Research Training

PROJECT_TITLE: Anesthesiology Research Training


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Microelectrode arrays have great promise clinically for bioelectronic medicine, especially for neural recording and stimulation, but currently, they have a high failure rate after months to years post-implant, thought to be due in part to inflammation. To assess the role of the inflammatory response in device failure and potentially overcome this limitation, this proposal aims to develop silica nanoparticles as an electrode coating material that can be loaded with DNA vectors for efficient and spatiotemporally targeted gene editing at the electrode interface to reduce the host immune response and improve device performance as well as study the immune response through loss of function experiments.

PI_NAMEs: WILLIAMS, NATHANIEL P (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Affect;Afferent Neurons;Antiinflammatory Effect;Area;Astrocytes;Biocompatible Coated Materials;bioelectronics;Brain;brain computer interface;Cell Culture Techniques;cell type;Cells;Cellular Morphology;Chronic;Cicatrix;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Development;Devices;DNA;DNA Sequence;Electrodes;Encapsulated;Equipment Malfunction;experimental study;Failure;Fluorescence;Foreign Bodies;Formulation;Gene Delivery;Gene Expression;Gene Modified;gene therapy;Gene Transduction Agent;Gene Transfer;Genes;Gliosis;Hearing;Immune response;Implant;implantable device;implantation;improved;In Vitro;in vitro testing;in vivo;Inflammation;Inflammatory;Inflammatory Response;Intervention;Knock-out;knockout gene;Life;limb loss;Limb structure;Longevity;loss of function;Measures;mechanical device;Medicine;Metals;Microelectrodes;Microglia;Modification;Monitor;Mus;nanoparticle;neural;neuron loss;Neurons;neurotransmission;novel;Pathway interactions;Patients;Pattern;Perception;Performance;Play;Porosity;prevent;Property;Prosthesis;prosthesis control;Proteins;recruit;Reporter;Reporter Genes;Resolution;response;robot control;Role;Sensory;Silicon Dioxide;Site;spatiotemporal;Specificity;Structure;Surface;System;Technology;technology development;Testing;Therapeutic;Therapeutic Uses;Time;Tissues;tool;Touch sensation;two photon microscopy;vector;Vision;Work

PROJECT_TITLE: Nanoparticle Coated Microelectrode Arrays for Electrochemically Controlled Gene Editing at the Electrode Site


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PHR: Project Narrative Aging is the number one risk factor for debilitating diseases such as neurodegeneration. The fundamental question that I will answer in this proposed research program is whether neuropeptides are key regulators of the pace of aging and lifespan. My findings will change the way we think about the regulation of whole-body aging and provide a tunable node within aging pathways to extend healthy lifespan.

PI_NAMEs: BEDBROOK, CLAIRE NICOLE (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Advisory Committees;African;age related;age related changes;age related decline;age related neurodegeneration;Age-associated memory impairment;age-related disease;Aging;aging mechanism;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;animal old age;Animals;Arousal;Autopsy;Behavior;Behavioral;Biological Assay;Brain;Brain region;career development;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;Cognitive;CRISPR/Cas technology;Data;Disease;Energy Metabolism;experimental study;extend lifespan;feeding;Foundations;Galanin;gene discovery;Genes;Genetic;Genetic Screening;Goals;Health;healthspan;Homeostasis;Human;hypocretin;Hypothalamic structure;Impaired cognition;In Situ;Inflammation;Institution;juvenile animal;Killifishes;Knock-in;Knock-out;knockout animal;Label;Laboratories;Libraries;Life;life span;Longevity;Measurement;Measures;Mediating;Memory Loss;Mentors;Methods;Modeling;mouse model;Mus;mutant;Nerve Degeneration;Neurodegenerative Disorders;Neuromedin U;neuromedin U receptor;Neuromodulator;Neurons;Neuropeptides;Neurosciences;novel;overexpression;Pattern;Peptides;Phenotype;Physiological;Pigmentation physiologic function;pituitary adenylate cyclase activating polypeptide;prevent;programs;Protocols documentation;rate of aging;receptor;Regulation;Research;Risk Factors;Role;screening;Signaling Molecule;single nucleus RNA-sequencing;skills;Sleep;Technology;Testing;tool;Training;Transcript;Transgenic Animals;Transgenic Organisms;Translating;Universities;Vertebrates;Work;β-amyloid burden

PROJECT_TITLE: Reprogramming organismal lifespan through modulation of neuropeptides

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: 8. Project Narrative Staphylococcus aureus is the leading cause of skin and soft tissue infections and a major cause of devastating heart, bone, and bloodstream infections, all resulting in nearly 12 million hospital visits each year. This, combined with resistance to multiple antibiotics, emphasizes the need for new strategies to combat infection, including those that target the regulation of disease-causing factors. This proposal seeks to understand novel peptidase regulation of the SaeR/S two component system in S. aureus virulence.

PI_NAMEs: BRINSMADE, SHAUN R (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Affect;Animals;Antibiotics;antimicrobial;Attenuated;Bacillus;Bacillus subtilis;Biochemical;Biology;Blood;Cell division;Collaborations;combat;commensal bacteria;Cytoplasm;Data;Defect;Disease;DNA-Binding Proteins;Endocarditis;Enzymes;Exhibits;Family;Family member;Gene Expression;Gene Expression Regulation;Genes;Genetic Screening;Growth;Heart;Homologous Gene;Hospitals;Housekeeping;Human;human pathogen;Individual;Infection;Infectious Skin Diseases;insight;Knowledge;Laboratories;Lactococcus lactis;Learning;Life;Mass Spectrum Analysis;member;Membrane Proteins;Metalloproteases;Modeling;mouse model;Mucous Membrane;Mutagenesis;mutant;Names;neurotransmission;neutrophil;next generation sequencing;novel;Order Spirochaetales;Organism;Osteomyelitis;overexpression;Pathogenesis;Pathogenicity;Peptide Hydrolases;Peptide Signal Sequences;Peptides;Phosphotransferases;Physiological;preference;Process;Production;promoter;protein degradation;protein-histidine kinase;Proteins;Proteobacteria;Proteomics;Regulation;Regulon;Resistance;response;Role;sensor;Sepsis;Signal Transduction;Site;Skin;Soft Tissue Infections;Staphylococcus aureus;Substrate Specificity;Surface;System;Systemic infection;Testing;Time;transcription factor;transcriptome sequencing;Virulence;Virulence Factors;Visit;Zinc

PROJECT_TITLE: Role of M3 peptidases in Staphylococcus aureus pathogenesis


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infectious Diseases;Precision Medicine;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The treatment for head and neck cancer includes toxic doses of chemotherapy and radiotherapy that cause extremely harmful side effects to the patients. It is important to conduct research into biomarkers that can help reduce side effects by identifying patients who may respond to targeted, less intense treatments. The proposed grant aims to discover those biomarkers by studying the differences in metabolism and metabolic compounds found within a head and neck cancer patient’s blood.

PI_NAMEs: ELDRIDGE, RONALD C (contact)

PROGRAM_OFFICER_NAME: BROWN, PATRICK

PROJECT_TERMS: Adverse event;Age;amino acid metabolism;Amino Acids;Anabolism;Apple;Bile Acids;Biological Markers;biomarker validation;Blood;Bypass;cancer biomarkers;Cancer cell line;Cancer Center;cancer clinical trial;cancer site;Categories;Characteristics;chemoradiation;Chemotherapy and/or radiation;Clinical;Clinical Research;Clinical Trials;clinically relevant;Coenzyme A;cohort;Cox Models;Data;Data Set;Development;Disease;DNA sequencing;Dose;Failure;fatty acid biosynthesis;Freezing;Future;Galactose Metabolism Pathway;Gene Expression;Genes;Genome;Glycolysis;Glycosaminoglycans;Goals;Grant;hazard;Head and Neck Cancer;head and neck cancer patient;Heterogeneity;high risk;Human Papillomavirus;improved;In Vitro;in vivo;Knowledge;Link;lipid biosynthesis;Lipids;machine learning algorithm;male;Measures;Metabolic;Metabolism;metabolomics;Mitochondria;multiple omics;Mutation;Niacinamide;novel;Oncogenes;Oncology;Oranges;Oropharyngeal;Outcome;Oxidative Phosphorylation;Patient Recruitments;Patients;Phase III Clinical Trials;phase III trial;PIK3CA gene;Plasma;precision medicine;precision oncology;Prognosis;prognostic;Prognostic Marker;prognostic of survival;prognostic value;programs;Publishing;Quality of life;Race;Regulation;Research;research clinical testing;Resolution;Risk;Running;sex;side effect;Signal Transduction;Site;Smoker;Smoking;Smoking History;Somatic Mutation;Source;standard care;Taurine;Testing;The Cancer Genome Atlas;Toxic effect;TP53 gene;Translating;translational research program;treatment response;Tryptophan;tumor;tumor metabolism;Tumor Tissue;Valine;Warburg Effect

PROJECT_TITLE: Validating a prognostic plasma metabolomic biomarker to improve precision medicine in head and neck cancer patients


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Palliative Care

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Despite limited access to specialty palliative care, there is a critical need to optimize advance care planning (ACP) and end-of-life (EOL) care for patients with chronic, life-limiting illness receiving home-based care. ACP video decision aids have shown promising efficacy for improving patient-clinician communication, increasing ACP documentation, and leading to more patient-centered and less costly care at the EOL, but they have not been tested in the home setting. This proposal seeks to assess the effectiveness of a home-based ACP video intervention (Home-ACP) for improving resuscitation preferences' documentation, ACP conversations, hospice utilization, and reducing costs of care in the last year of life for patients with chronic, life-limiting illness receiving home-based care.

PI_NAMEs: EL-JAWAHRI, AREEJ  (contact);VOLANDES, ANGELO

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Address;Adult;Advance Care Planning;burden of illness;care costs;care systems;Caring;Certification;Chronic;Chronic Disease;Clinical;Clover;Communication;comparison intervention;Complex;Consult;Consultations;Control Groups;cost;cost comparison;Country;County;Decision Aid;Decision Making;Dissemination and Implementation;Documentation;Effectiveness;effectiveness evaluation;Electronic Health Record;Emotional;end of life;end of life care;Ensure;Environment;ethnic diversity;evidence base;Exposure to;Foundations;Future;future implementation;Goals;Health;health literacy;Health system;Healthcare Systems;Home;Home visitation;hospice environment;hospice utilization;Hospitalization;Hospitals;improved;Infrastructure;innovation;Inpatients;Intervention;Knowledge;Language;Life;literacy;Medical;medical specialties;Medicare;New Jersey;Nurses;nursing intervention;Outcome;palliative;Palliative Care;Patient Care;patient oriented;Patient Outcomes Assessments;patient population;patient-clinician communication;Patient-Focused Outcomes;Patients;Population;pragmatic trial;Predictive Analytics;preference;Prognosis;programs;Proliferating;Provider;racial diversity;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;recruit;Research;Resources;Resuscitation;satisfaction;Services;Site;Spanish;success;Technology;Testing;Time;Training;treatment arm;treatment as usual;visual information;Vulnerable Populations;Work

PROJECT_TITLE: Randomized Trial of a Home-Advance Care Planning Video Intervention for Patients with Life-limiting Illness

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


NIH_SPENDING_CATS: Cancer

ORG_CITY: LA JOLLA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Translational cancer research that improves patient health is a team sport that moves innovative discoveries from (A) basic research to (B) preclinical validation (often utilizing biobanked tissue) to (C) clinical implementation via entrepreneurship and commercialization. We propose to create the Surgical Oncologists as Scientists (SOAS) Training Program centered on formal training of two new surgeon-scientists annually in three topics, namely: 1) the tumor microenvironment (TME); 2) tissue biobanking via our College of American Pathologists (CAP)-certified biorepository; and 3) innovation & entrepreneurial skills. The SOAS Training Program is committed to training collaborative surgeon-scientists who will become future leaders in academic surgery and oncology and will be trained to participate in translating innovative new discoveries into improved clinical cancer care.

PI_NAMEs: CHEN, YUAN ;SICKLICK, JASON KEITH (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_DEPT: OTHER BASIC SCIENCES

PHR: Narrative The educational and research mission of the UCLA Tumor Cell Biology training program is to train the next generation of biomedical scientists and clinician scientists in i) the application of "cutting edge conceptual and technical strategies to cancer biology and medicine and ii) the multidisciplinary, team approaches required to apply those strategies and insights iteratively between the laboratory and the bedside.

PI_NAMEs: CROOKS, GAY M (contact);NATHANSON, DAVID A.

PROJECT_TERMS: Training Programs;Tumor Cell Biology

PROJECT_TITLE: Tumor Cell Biology Training Program


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Cutting-edge research in brain science is increasingly interdisciplinary, and traditional discipline-based graduate programs strain to accommodate this development. The Cognitive, Computational & Systems Neuroscience (CCSN) pathway at Washington University in St. Louis provides an integrative model for training 21st century brain scientists with a unique set of quantitative and professional skills that effectively position them to produce transformative breakthroughs related to mental illness, neurological disease, and neural engineering. This training grant will support five pre-doctoral trainees.

PI_NAMEs: BRAVER, TODD S;PADOA-SCHIOPPA, CAMILLO  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Cognitive;Neurosciences;System;Training

PROJECT_TITLE: Interdisciplinary Training in Cognitive, Computational and Systems Neuroscience (CCSN)


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Spinal muscular atrophies cause early onset, severe muscle weakness. Although new gene-targeting therapeutics are a breakthrough, efficacy in patients remains highly variable. Here, we will define factors limiting current treatments, characterize molecular and cellular mechanisms of disease, and identify novel therapeutic strategies in order to improve quality of life for individuals with SMAs and related neuromuscular disorders.

PI_NAMEs: SUMNER, CHARLOTTE JANE (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Animals;antagonist;Automobile Driving;Blood;Cations;Cell surface;clinical efficacy;Development;Disease;Distal Spinal Muscular Atrophy;dominant genetic mutation;early onset;Endothelial Cells;Exhibits;Gene Activation;Gene Targeting;Genes;Genetic;genetic regulatory protein;Human;human disease;Impairment;improved;in utero;Individual;induced pluripotent stem cell;insight;Knock-in Mouse;loss of function mutation;Modeling;Molecular;mortality;Motor;Motor Neuron Disease;Motor Neurons;mouse model;Mus;Muscle Weakness;mutant;Mutation;Neonatal;neural;Neurologic;Neuromuscular Diseases;neuropathology;new therapeutic target;Normal Range;novel;novel therapeutic intervention;Pathology;Pathway interactions;Patient Care;Patients;Phenotype;Pregnancy;programs;protein protein interaction;Proteins;Quality of life;receptor;Research;Resources;Role;SMN expression;SMN1 gene;Spinal Muscular Atrophy;success;symptom treatment;targeted treatment;Technology;Therapeutic;therapeutic target;Translating;Treatment Efficacy;Vanilloid

PROJECT_TITLE: Translating Pathomechanisms into Treatment for Spinal Muscular Atrophies