NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: SEATTLE

PHR: Project Narrative Treatment dropout is a primary challenge for individuals suffering with posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) following trauma exposure. A clearer understanding of the factors that contribute to dropout will enable us to identify individuals at risk of drop out and guide treatment retention efforts. There is a crucial need for strategies that decrease the likelihood of treatment dropout so that individuals with PTSD and alcohol misuse may receive the full benefit of treatment, increasing the likelihood of positive long-term outcomes for this vulnerable population.

PI_NAMEs: LEHINGER, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: active method;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol misuse;alcohol use disorder;Alcohols;Award;Behavior;Characteristics;Clinical;Clinical Trials;Clip;coping;Data;Development;Distress;Dropout;Drops;Early Diagnosis;emotional distress;Emotions;Enrollment;experience;Funding;Grant;Heavy Drinking;improved;Individual;innovation;interest;Intervention;Interview;Manuscripts;Measures;Mental Depression;Methods;Negative Reinforcements;novel;Outcome;Participant;Patient Self-Report;Population;Post-Traumatic Stress Disorders;Prediction of Response to Therapy;Process;Provider;reduce symptoms;Research;Research Personnel;research study;Risk;Self Medication;Services;Severities;sexual assault;Signal Transduction;skill acquisition;skills;skills training;Slice;Specific qualifier value;Statistical Methods;Symptoms;Testing;theories;Thinness;Training;Translating;Trauma;trauma exposure;treatment comparison;Treatment outcome;Vulnerable Populations;Woman;women's clinical trial;Writing

PROJECT_TITLE: Understanding Treatment Dropout Among Women with Posttraumatic Stress Disorder and Heavy Drinking


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Nutrition;Pediatric;Prevention

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Food allergy affects nearly 10% of the United States population, and misdiagnosis leads to difficult, anxiety- provoking, and growth-limiting food avoidance. Current diagnostic tools are fraught with inaccuracy or require ingesting possible food allergens under medical monitoring, which is cumbersome, risky, and costly. The goal of this project is to understand the role of leaky skin and gut barriers in food allergy to develop more accurate and less onerous tests to diagnose food allergy.

PI_NAMEs: SCHULER, CHARLES F (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acceleration;Acute;Affect;Allergic;Allergic Reaction;Allergy to peanuts;Anaphylaxis;Anxiety;Area;biobank;Biological Markers;biomarker discovery;Birth;Blood;career development;Cells;Child;Clinical;clinical application;Clinical Immunology;Clinical Research;cohort;cost;Data;Data Set;design;Development;Diagnosis;Diagnostic;diagnostic tool;dietary;Disasters;Disease;Doctor of Philosophy;Eating;Enhancers;Environment;Eosinophilic Esophagitis;Epinephrine;Epithelium;Esophagus;exome sequencing;experience;filaggrin;Food;food allergen;food avoidance;food challenge;Food Hypersensitivity;food standard;Functional disorder;Genes;genetic variant;genomic data;Genomics;Goals;Growth;Human;Hypersensitivity;Hypersensitivity skin testing;IgE;Immune;immune activation;Immune system;Immunology;Impairment;improved;in vivo;Incidence;Individual;Inflammatory;Ingestion;innovation;Intestinal permeability;junctional adhesion molecule;Laboratory Research;Lead;Learning;Life;Measurement;Measures;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Michigan;Modality;Monitor;Mucous Membrane;Mus;nutrition;Oral;Oral cavity;Outcome;outcome prediction;Pathogenesis;Pathogenicity;Patients;Permeability;Persons;Physicians;polygenic risk score;Population;Predictive Value;Program Development;Promoter Regions;Protease Inhibitor;Proteins;Reaction;real time monitoring;Research;Research Personnel;Risk;Role;Safety;Sampling;Scientist;secondary outcome;Serine;Serology test;Severities;skills;Skin;skin barrier;Symptoms;Testing;Tight Junctions;Time;Training;United States;Universities;Variant;Water;Work

PROJECT_TITLE: The role of epithelial barrier dysfunction in food anaphylaxis

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Children with high-risk solid tumors including sarcoma, renal tumors and other rare solid tumor types have experienced a disproportionately high rate of death from disease highlighting the unmet need for effective therapies. With increased access to potential curative therapies resulting from passage of the Research to Accelerate Cures and Equity (RACE) for Children Act, development of the NCI Pediatric In Vivo Testing Program will facilitate the evaluation and prioritization of drugs for pediatric clinical development. We propose to apply the unique expertise and comprehensive patient-derived xenograft (PDX) tumor model portfolio assembled by our Research Team to test drugs relevant to pediatric sarcoma, renal tumors and other rare solid tumors.

PI_NAMEs: DELA CRUZ, FILEMON S;KUNG, ANDREW L (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acceleration;Adoption;advanced disease;Antineoplastic Agents;Authorization documentation;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;biomedical referral center;Biometry;Bone Tissue;California;Cancer Biology;cancer clinical trial;Cancer Model;Cause of Death;Cell Line;Characteristics;Child;Childhood;childhood sarcoma;Childhood Solid Neoplasm;Clinical;clinical application;clinical development;clinical translation;Clinical Trials;clinically relevant;Complement;conventional therapy;Coupled;curative treatments;Cytotoxic Chemotherapy;Data Analyses;Death Rate;Desmoplastic Small Round Cell Tumor;Development;Disease;disease heterogeneity;disorder risk;drug development;Drug resistance;drug testing;early phase clinical trial;effective therapy;Ensure;Equipoise;Equity;established cell line;Evaluation;Excision;experience;Failure;Genetic;Genetic Transcription;Genomics;Growth;high risk;Histologic;improved;In Vitro;in vivo evaluation;Inter-tumoral heterogeneity;Kidney Neoplasms;Light;Malignant Childhood Neoplasm;Malignant Neoplasms;Memorial Sloan-Kettering Cancer Center;Methodology;Modeling;molecular drug target;Mus;neoplastic cell;New Agents;novel therapeutics;oncology program;Operative Surgical Procedures;Outcome;patient derived xenograft model;patient population;patient response;Patients;Pediatric Oncology;Pharmaceutical Preparations;pre-clinical;preclinical evaluation;preclinical study;Preclinical Testing;predictive marker;Predictive Value;programs;Proteins;Radiation therapy;Refractory;Relapse;Reporting;Research;Research Design;response;San Francisco;Sarcoma;Serial Passage;Soft tissue sarcoma;Solid Neoplasm;targeted treatment;Therapeutic;Therapeutic Agents;Time;Translating;translational potential;Translations;treatment response;tumor;tumor xenograft;United States;Universities;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Pediatric Preclinical In Vivo Testing Center for Pediatric Sarcoma and Other Solid Tumors


NIH_SPENDING_CATS: Digestive Diseases;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Nutrition

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: These studies will extend our investigations into how viral replication compartments, which are conserved among all (+)RNA viruses, are formed via manipulation of cellular lipid metabolism. This may have implications for design of broad-spectrum (+)RNA antivirals that target replication compartments.

PI_NAMEs: RANDALL, GLENN C (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acids;Anti-viral Agents;Binding Proteins;Biological Assay;Bromoviridae;Cell membrane;Cell Nucleus;Cells;Cholesterol;Choline;Consensus;Data;defined contribution;design;Endoplasmic Reticulum;Enzymes;Family;Family Picornaviridae;Fatty Acids;Flaviviridae;Genes;Golgi Apparatus;Hepatitis C;Hepatitis C virus;immune RNA;Immune signaling;Infection;insight;Investigation;Lecithin;lipid metabolism;lipid transfer protein;Lipids;long chain fatty acid;Membrane;Membrane Lipids;Modeling;Peptide Hydrolases;Phosphatidylinositols;Phospholipids;Phosphotransferases;Process;Property;Proteomics;Publishing;receptor;recruit;replicase;Research;Research Proposals;RNA;RNA Degradation;RNA Viruses;Role;Site;Viral;Viral Proteins;viral RNA;Virion;Virus;Virus Replication

PROJECT_TITLE: Manipulation of lipid metabolism in (+)RNA virus replication

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Human genetic studies have produced hundreds of thousands of loci and candidate genes for a wide range of diseases, but often have not resulted in sufficient mechanistic insight to lead to actionable changes in prevention, diagnosis, or treatment. One of the rate-limiting steps has been animal modeling which is typically not feasible at a large enough scale in animals closely related to humans, though in recent years the zebrafish has begun to fill this gap. We have created, maintained and continued to develop a Zebrafish Community Resource to bring state of the art technologies and disease modeling to investigators studying human disease.

PI_NAMEs: GOESSLING, WOLFRAM ;MACRAE, CALUM A. (contact);ZON, LEONARD IRA

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Address;Alleles;Animal Model;Animals;Area;assay development;ATAC-seq;Back;Bar Codes;Biological Assay;Biological Models;Biology;Blood;Candidate Disease Gene;causal variant;Cell Lineage;cell type;Chemicals;ChIP-seq;Chronic Disease;Clonality;Clustered Regularly Interspaced Short Palindromic Repeats;Code;combinatorial;Communities;Companions;Complex;cost;CRISPR/Cas technology;design;Diagnosis;Dimensions;Disease;disease model;DNA methylation profiling;Drops;Evaluation;Event;Exons;experience;Fishes;gene environment interaction;gene interaction;Genes;Genetic;Genetic Diseases;Genetic Models;Genetic Recombination;Genetic study;genome wide association study;genomic locus;Genomics;Genotype;Germ Lines;Heart;Hematopoiesis;Hematopoietic;Human;human disease;Human Genetics;insight;Kidney;Liver;Maps;model organism;Modeling;Modification;mosaic;Mutagenesis;new technology;Organ;Outcome;Pathogenesis;Phenotype;Physiological;Play;Prevention;programs;Regulatory Element;Reproducibility;Research Personnel;Resolution;Resources;Risk;Role;role model;single-cell RNA sequencing;Somatic Mutation;stem cells;System;Techniques;Technology;Testing;Time;Tissues;tool;Toxicology;trait;transcriptome sequencing;Translating;Transplantation;Untranslated RNA;Validation;Variant;Work;Zebrafish;zebrafish genome

PROJECT_TITLE: A community resource for germline and somatic genetic disease modeling in zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(56)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: COLUMBIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Narrative  Cholinergic transmission in the amygdala is critical for emotional memory as demonstrated by the observation that deficits in this signaling underlie emotional disturbances associated with a variety of disorders, including Alzheimer’s disease, drug addiction, anxiety and trauma-related disorders, and schizophrenia. The goal of this project is to determine at a cellular and circuit level how cholinergic signaling modulates amygdalar circuits to regulate emotional memory. These studies will further our understanding of the cellular and circuit mechanisms by which acetylcholine acts to regulate emotion and inform novel avenues for the development of therapeutics to treat a variety of debilitating emotional disorders.

PI_NAMEs: JASNOW, AARON M;MOTT, DAVID D (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Acetylcholine;Adult;Affect;Alzheimer's Disease;Amygdaloid structure;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;Area;basal forebrain;Behavior;Behavioral;Brain;Brain region;cell type;Cholecystokinin;cholinergic;combat;Communication;conditioned fear;Cues;Data;depressive symptoms;Development;Discrimination;Disease;Disinhibition;Drug Addiction;Electroencephalography;Electrophysiology (science);Emotional;emotional behavior;Emotional disorder;Emotional Disturbance;emotional stimulus;Emotions;Frequencies;Fright;Goals;hippocampal pyramidal neuron;Human;Impairment;improved;in vivo;information processing;innovation;Interneurons;Knowledge;Learning;learning extinction;Life;Mammals;Medial;Memory;Mental disorders;mouse model;Muscarinic Acetylcholine Receptor M3;nerve supply;neurobiological mechanism;Neurons;Neurotransmitters;novel;novel therapeutics;optogenetics;Patients;Periodicity;Population;Prefrontal Cortex;Regulation;Resolution;Role;Safety;Schizophrenia;Series;Signal Transduction;Somatostatin;Symptoms;Synapses;Techniques;Testing;Therapeutic;therapeutic development;Transgenic Mice;transmission process;Trauma

PROJECT_TITLE: Cholinergic regulation of amygdalar circuits in emotional memory

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer;Nutrition

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative  There is a critical need to understand the mechanisms of action of anti-neoplastic agents that target nutrient dependency in cancer cells. The objectives of this application are to determine the roles and mechanisms of cystine transporter SLC7A11 in regulating nutrient dependency and to therapeutically target nutrient dependency in cancers with aberrant expression of SLC7A11. Our proposed studies will have significant impact on both our understanding of the fundamental mechanisms of nutrient dependency and our ability to therapeutically target nutrient dependency in cancer treatment.

PI_NAMEs: GAN, BOYI  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Amino Acid Transporter;Antineoplastic Agents;antiporter;Biochemical Pathway;cancer cell;cancer therapy;Cell Death;Cell Death Induction;Cell Line;Cell Survival;Cells;clinical care;CRISPR screen;Cysteine;Cystine;Data;Dependence;Development;Disulfides;Equilibrium;Exhibits;Genetic;Glucose;Glucose Transporter;Glucosephosphates;Goals;Homeostasis;Human;Immune system;Impairment;inhibitor;innovation;inorganic phosphate;insight;leukemia;Link;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metabolic;Metabolism;mutant;Mutation;NADP;Nature;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Nutrient;nutrient metabolism;Outcome;overexpression;Oxidation-Reduction;Pathway interactions;patient derived xenograft model;Pentosephosphate Pathway;Pharmaceutical Preparations;pre-clinical;Pre-Clinical Model;programs;Radiation therapy;Research;Role;small molecule;Solid Neoplasm;standard of care;Starvation;success;targeted agent;Testing;Therapeutic;therapeutic target;Translations;tumor;uptake;Xenograft procedure

PROJECT_TITLE: Targeting SLC7A11-induced nutrient dependency in cancer: mechanisms and preclinical translation

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Congenital Structural Anomalies;Digestive Diseases;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Wound Healing and Care

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Biliary atresia is one of the most devastating liver diseases in the pediatric population worldwide, developing in newborn infants after a prenatal insult to the extrahepatic bile ducts. The proposed work seeks to understand the potential ways – healing vs. injury progression – that the bile duct responds to this insult in the prenatal, perinatal, and early postnatal periods. Understanding these wound healing behaviors, particularly those occurring shortly after birth when diagnosis of biliary atresia is possible, offers the potential to develop therapies that shift the balance from progression to healing.

PI_NAMEs: WELLS, REBECCA G (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Adult;Affect;Behavior;bile duct;Biliary Atresia;Bilirubin;Birth;Cells;Child;Childhood;cholangiocyte;Cicatrix;Collagen;Collagen Type I;Data;Deposition;Development;Diagnosis;Disease;Disease Progression;Duct (organ) structure;Early Diagnosis;Equilibrium;Event;Extrahepatic Bile Ducts;fetal;Fetus;Fibroblasts;Fibrosis;Goals;Growth Factor;healing;Hyaluronic Acid;in utero;In Vitro;in vivo;injured;Injury;Interleukin-10;Intervention;Liver;Liver Cirrhosis;Liver diseases;liver transplantation;Methods;Molecular Weight;Morbidity - disease rate;Mothers;Natural regeneration;Nature;Neonatal;neonate;Newborn Infant;Obstruction;Oxidation-Reduction;Perinatal;Population;postnatal period;Pregnancy;prenatal;programs;Rare Diseases;Recovery;regenerative;repaired;Reporting;response;response to injury;Role;Stress;Testing;Therapeutic;therapeutic target;therapy development;Tissues;Work;wound;wound healing

PROJECT_TITLE: Injury, Progression, and Fibrosis of the Extrahepatic Bile Duct

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE  The olfactory system allows humans to evaluate the quality of food sources and to avoid harmful chemicals, thereby promoting overall health and quality of life. Relatively little is known about how higher order brain structures process olfactory information in mammals. We are using a combination of different techniques to understand the importance of an understudied brain region, the dorsal tenia tecta, for olfactory perception.

PI_NAMEs: DEWAN, ADAM KABIR (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Acceleration;Anatomy;Animals;Anxiety Disorders;Atlases;Behavior;biological adaptation to stress;Biological Assay;Brain;Brain region;Cells;Chemicals;Code;Communities;conditioned fear;Data;density;Dorsal;Electrophysiology (science);Emotional;excitatory neuron;experience;experimental study;Fiber;food quality;Freezing;Glutamates;Health;Hippocampus;Human;Image;Individual;inhibitory neuron;insight;Investigation;Mammals;Maps;Memory;Mental Health;Methods;microendoscope;Mus;neural;Neurons;Odors;olfactory bulb;Olfactory Cortex;Olfactory Pathways;olfactory stimulus;optogenetics;Output;Perception;Play;Population;Post-Traumatic Stress Disorders;Process;Property;Psyche structure;Psychosocial Stress;Quality of life;Rattus;receptor;Research;response;restraint stress;Role;segregation;Sensory;sensory system;Signal Transduction;Smell Perception;Source;Stimulus;Stream;Stress;Structure;Techniques;Transgenic Mice

PROJECT_TITLE: Odor Coding in the Dorsal Tenia Tecta

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: This project will determine how the emerging human pathogen, Anaplasma phagocytophilum, parasitizes and disseminates from host cells to survive and cause disease. Our work has broad- reaching implications, will advance understanding of microbial pathogenesis, and may foster development of new treatments for infectious diseases.

PI_NAMEs: CARLYON, JASON A (contact);CHALFANT, CHARLES E.

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Acceleration;Address;Anaplasma phagocytophilum;Anaplasmosis;Bacteria;Binding Sites;Biogenesis;Cell Communication;Cell membrane;Cell Physiology;Cells;ceramide 1-phosphate;ceramide kinase;Ceramides;Cholesterol;Communicable Diseases;Data;defined contribution;Development;Disease;emerging human pathogen;Endosomes;Endothelial Cells;Enzymes;Etiology;Exocytosis;exosome;Fostering;Funding;Golgi Apparatus;granulocyte;Growth;HL-60 Cells;host-microbe interactions;Human;Immunity;immunopathology;improved;In Vitro;in vivo;Incidence;Infection;infectious disease treatment;Inflammation;innovation;inorganic phosphate;Knowledge;Link;lipidomics;Lipids;MAPK8 gene;Mediating;Membrane;Metabolic;Metabolism;microbial;Modeling;Molecular;molecular modeling;Multivesicular Body;Mus;Myeloid Cells;neutrophil;novel;Organelles;Parasites;parasitism;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Phosphatidylinositol 4,5-Diphosphate;Phosphorylation;Process;Progranulocytes;Proliferating;Proteins;Proteomics;recruit;Research;response;Role;Signal Transduction;Sorting;Sphingolipids;Sphingomyelins;Testing;Theft;Tick-Borne Diseases;tool;trafficking;trans-Golgi Network;United States National Institutes of Health;Vacuole;Vesicle;Work

PROJECT_TITLE: The roles of ceramide and its derivatives in A. phagocytophilum pathogenesis

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Palliative Care;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: VILLANOVA

ORG_NAME: VILLANOVA UNIVERSITY

PHR: Project Narrative Because traumatic brain injury (TBI) is a major public health problem for civilian and military populations, effective rehabilitation approaches for TBI are essential. An in-home, family-inclusive program (the Veterans' In- home Program [VIP]) showed efficacy with veterans with TBI and their families and was highly acceptable to both. Building on the VIP, the HOME intervention will be tested with veterans and civilians with chronic TBI- related symptoms and family members in a 2-group randomized controlled trial.

PI_NAMEs: MORIARTY, HELENE JOY (contact);WINTER, LARAINE

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Aftercare;Age;attentional control;Behavioral Symptoms;care giving burden;Caregiver Burden;Caregivers;Caring;Chronic;Chronic Phase;Clinic;Cognitive;Communities;community reintegration;comparison control;daily functioning;depressive symptoms;design;disability;Eligibility Determination;Emotional;emotional symptom;Enrollment;Environment;Epidemic;experience;Family;Family Caregiver;family management;Family member;Funding;Goals;Guidelines;Heterogeneity;Home;Home environment;improved;indexing;Individual;Injury;innovation;Intervention;intervention effect;Interview;Knowledge;Learning;Left;Maintenance;Medical;Memory Loss;Mental Depression;Methodology;Military Personnel;Neurobehavioral Manifestations;Occupational Therapist;Occupational Therapy;Outcome;Patients;Persons;Phase;Physical environment;physical symptom;Physiological;primary outcome;programs;Protocols documentation;Public Health;Quality of life;Randomized, Controlled Trials;Recovery;rehabilitation strategy;Rehabilitation therapy;Research;restoration;Role;Sample Size;Sampling;Schools;Self Management;Services;Severities;sex;social;Social Environment;Standardization;Subgroup;Symptom Burden;symptom management;Symptoms;Testing;theories;Time;Traumatic Brain Injury;treatment effect;trial design;Underserved Population;United States National Institutes of Health;Veterans;Work

PROJECT_TITLE: A randomized controlled trial of an innovative in-home rehabilitation program for persons with TBI and their families: Home-based Occupational-therapy and Management of the Environment (HOME for Us)

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: PROJECT NARRATIVE The number of physician-scientists in the United States has been steadily declining, and there is a major need for more basic and translational researchers focused on digestive, pancreatic, and liver related research. The Training Program in Gastrointestinal Sciences at the University of Pennsylvania Perelman School of Medicine has had historic success and remains at the leading edge in nurturing young researchers and ensuring their maturation into independent investigators in digestive, pancreatic, and liver diseases.

PI_NAMEs: KATZ, JONATHAN P (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease), or other disorders can become unable to move or speak despite being awake and alert. In this project, we seek to further translate knowledge about interpreting brain signals related to movement, and to further develop an intracortical brain-computer interface (iBCI) that could restore rapid and intuitive use of communication apps on tablet computers by people with paralysis.

PI_NAMEs: HOCHBERG, LEIGH R (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: alternative communication;Amyotrophic Lateral Sclerosis;arm;Augmentative and Alternative Communication;awake;Brain;brain computer interface;BRAIN initiative;Brain Stem Infarctions;Calibration;Caregivers;Clinical Research;Clinical Trials;Collaborations;Communication;communication device;Competence;Computer software;Computers;Darkness;Data;deep learning;design;Detection;Development;Devices;Dimensions;Disease;expectation;experience;Family;Fatigue;feasibility trial;Feedback;first-in-human;flexibility;Friends;Gestures;Hand;Home;Human;Human Activities;Implant;improved;Individual;Industry;Injury;innovation;Institution;Intention;Interactive Communication;Intuition;Knowledge;Language;Lighting;Location;Locked-In Syndrome;long short term memory;Methods;Modeling;Modernization;Motor;Motor Cortex;motor disorder;motor impairment;Movement;Mus;National Institute on Deafness and Other Communication Disorders;neural;neural implant;Neurons;neuroregulation;nonhuman primate;novel;Outcome Measure;Paralysed;Participant;Pattern;Performance;Persons;phrases;preference;Research;Research Support;Residual state;Signal Transduction;Speech;Speed;Surveys;System;Tablet Computer;Tablets;Technology;Testing;Time;tool;Touch sensation;touchscreen;Translating;Translations;two-dimensional;United States National Institutes of Health;wireless

PROJECT_TITLE: Intuitive, complete neural control of tablet computers for communication


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE As cannabis legalization has expanded, the incidence of driving under the influence of cannabis has increased and concurrent use of cannabis and alcohol has become more common. In this project, participants will administer one of two novel forms of cannabis (oral and vaporized) in combination with alcohol, and we will evaluate the individual and interactive effects of these substances on cognitive performance, driving ability, and subjective intoxication. Results will further the development of a promising novel tool for detecting cannabis impairment (the DRUID app) and inform regulatory and policy decisions concerning cannabis and alcohol.

PI_NAMEs: SPINDLE, TORY RICHARD (contact)

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: absorption;Accidents;Acute;Alcohol consumption;alcohol effect;Alcoholic Intoxication;Alcohols;Attention;automobile accident;Automobile Driving;Behavioral;Blood;breath alcohol measurement;Cannabis;cannabis administration;Cognitive;cognitive ability;cognitive function;cognitive performance;Controlled Study;Data;design;Detection;Development;Dose;Double-Blind Method;driving performance;driving skills;driving under influence;Drug usage;epidemiology study;experience;field sobriety tests;General Population;Human;impaired driving performance;Impairment;improved;Incidence;Individual;instrument;Intoxication;Laboratories;Laboratory Study;Legal;Location;marijuana legalization;marijuana use;Measures;Methods;novel;Oral;Outpatients;Participant;Performance;performance tests;Persons;Pharmaceutical Preparations;Placebo Control;Placebos;Policies;Protocols documentation;Psychomotor Impairments;Psychomotor Performance;Public Health;Questionnaires;Randomized;Research;Risk;Route;Safety;Self Administration;skills;Smoke;Specificity;Task Performances;Time;tool;Vaporizer;Workplace

PROJECT_TITLE: The Impact of Cannabis Route of Administration and Co-Administration of Alcohol on Impairment

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: SALT LAKE CITY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Obesity affects more than 1.4 billion adults worldwide and is a significant risk factor for chronic diseases such as hypertension, diabetes, and cardiovascular diseases. However, present non-operative treatment options of obesity are woefully inadequate – intragastric balloons have been demonstrated to be effective in enabling temporary weight loss (~25-30% of excess body weight) but are fundamentally limited to very selected patients as a temporary treatment or as a bridging intervention to bariatric surgery. The proposed research will overcome the limitations of IGB by creating an ingestible gastric-resident electronic-enhanced metamaterial architecture (iGEM) that can transform obesity treatment with a digital-based personalized and dynamic obesity treatment strategy that can be optimized based on safety consideration, patient’s treatment goals, and the quality of life.

PI_NAMEs: KONG, YONG LIN  (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: 3-Dimensional;3D Print;Abdominal Pain;Adult;Affect;Air;Animal Model;Architecture;bariatric surgery;Biochemical;biomaterial compatibility;Body Weight;Body Weight decreased;Cardiovascular Diseases;Chemicals;Chronic Disease;Clinical;Clinical Research;Complex;Consumption;cost;Data;design;Devices;Diabetes Mellitus;digital;Dissociation;Doctor of Philosophy;Dosage Forms;Effectiveness;Electric Capacitance;Electronics;Eligibility Determination;Endoscopy;Environment;Excision;Excretory function;experience;Feedback;Feeling;Foundations;Gastric Balloon;gastrointestinal symptom;Goals;Healthcare;Hybrids;Hypertension;Implant;improved;Intervention;Intestinal Obstruction;invention;Magnetism;Measurement;Measures;Mechanics;Metabolic;Methodology;Monitor;Morbidity - disease rate;Nausea;novel;Obesity;Obesity associated disease;obesity treatment;Operative Surgical Procedures;Oral;Oral Ingestion;Outcome;Patient Selection;Patients;Perforation;Performance;porcine model;premature;pressure;pressure sensor;prevent;Printing;programs;Quality of life;rational design;Reflux;Reporting;Research;residence;Risk;Risk Factors;Rupture;Safety;Saline;Satiation;sensor;Serious Adverse Event;simulation;Stents;Stomach;Structure;System;Temperature;Time;Treatment Effectiveness;treatment strategy;Ulcer;Vomiting;wireless;wireless sensor;Work

PROJECT_TITLE: Ingestible gastric-resident electronic metamaterials architecture (iGEM) for the treatment of obesity

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Radiation Oncology;Rare Diseases

PHR: Project Narrative Our goal is to develop a novel non-invasive, safe, sensitive, and specific methodology to monitor genetically altered human immune cells, called chimeric antigen receptor (CAR) T cells, after they have been transferred into patients to treat cancer. We have developed a DOTA antibody reporter, which binds to a clinically employed radiometal complex (DOTA), and we propose to use this tool for tracking transfused CAR T cells to determine their location and study their functionality, and in case of imminent treatment failure, to exploit these engineered T cells to deliver a deadly payload to the tumor with the goal of improving the anti-tumor efficacy of CAR T-cell therapy. By combining next-generation armored CAR T cells with molecular imaging and targeted radionuclide therapy, this project has the potential to significantly endow these “living” drugs with novel attributes to increase their therapeutic potency and safety.

PI_NAMEs: KREBS, SIMONE  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Ablation;Adoptive Cell Transfers;Affinity;Animals;Antibodies;Antigen Receptors;Antigens;Autoradiography;B lymphoid malignancy;Binding;Biodistribution;Biological;Biological Assay;CAR T cell therapy;CD19 gene;CD40 Antigens;CD40 Ligand;Cell Count;cell killing;Cell surface;Cells;cellular imaging;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical application;clinical translation;Clinical Trials;clinically relevant;Complex;contrast imaging;cytotoxic;Dose;dosimetry;Drug Kinetics;effector T cell;Endowment;engineered T cells;Ensure;Exclusion;Excretory function;exhaustion;Exhibits;gene function;Gene Modified;Generations;Goals;Haptens;Hepatobiliary;Human;Image;Immune;immunodeficiency;Immunohistochemistry;ImmunoPET;improved;In Vitro;in vivo;in vivo monitoring;Inflammatory;Inflammatory Response Pathway;insight;Kinetics;Lanthanoid Series Elements;Location;Malignant Neoplasms;Mentored Clinical Scientist Development Program;method development;Methodology;Methods;Modeling;molecular imaging;Molecular Target;Monitor;mouse model;Mus;neoplastic cell;next generation;novel;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Play;Positron-Emission Tomography;preclinical study;preservation;Proteus;Radiation Toxicity;Radiometry;Radionuclide therapy;Relapse;Reporter;Reporter Genes;response;Role;Safety;Series;single photon emission computed tomography;Specificity;success;System;T cell therapy;T-Cell Receptor Therapy;T-Lymphocyte;theranostics;Therapeutic;therapeutic target;Therapy trial;Time;Tissues;Titrations;tool;trafficking;Transfusion;translational approach;Translations;treatment effect;Treatment Efficacy;Treatment Failure;tumor;tumor heterogeneity;tumor microenvironment;uptake;Variant;Visualization;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Interrogating the in vivo pharmacokinetics of armored CARs with radiohapten capture

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: MELBOURNE

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF MELBOURNE

PHR: NARRATIVE Mucosal Associated Invariant T (MAIT) cells are an abundant population of T cell in humans. Presently, we know very little about the function of MAIT cells, their role in protecting humans from microbial infection, or how they may cause disease (e.g. autoimmunity). This proposal will shed fundamental insight into the nature of the antigens that can activate or inhibit MAIT cell function.

PI_NAMEs: MCCLUSKEY, JAMES  (contact)

PROJECT_TERMS: adaptive immunity;Agonist;Antigen Presentation;Antigens;Ants;Autoimmune Diseases;Autoimmunity;B-Cell Antigen Receptor;Binding;Biochemical;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cell surface;cell type;Cells;Chemicals;chronic inflammatory disease;Complex;Cytoprotection;Dedications;Detection;detection platform;Disease;effector T cell;Environment;Evolution;Folic Acid;Francisella;Future;gastrointestinal;Health;Homeostasis;Human;Immune;Immune response;Immunity;Immunologic Surveillance;immunopathology;Immunotherapeutic agent;in vivo;Infection;Inflammatory;Inflammatory Bowel Diseases;insight;Legionella longbeachae;Ligand Binding;Ligands;Lipids;Liver;lumazine;Lung;Major Histocompatibility Complex;Malignant Neoplasms;Mammals;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;MHC Class I Genes;Microbe;microbial;Mucous Membrane;Mycobacterium tuberculosis;Nature;novel;nutrition;Outcome;pathogen;Pathogen detection;Pathway interactions;Peptic Ulcer;Peptides;Periodontal Diseases;peripheral blood;Pharmaceutical Preparations;Phenotype;Population;prevent;Probability;Proteins;Pterins;Reaction;Recurrent tumor;Regulation;repaired;Riboflavin;Role;System;T cell response;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Therapeutic;Tissues;Tuberculosis;tumor;Uracil;Virus Diseases;Work

PROJECT_TITLE: Investigating the basis of MAIT cell antigen potency

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Pediatric;Rare Diseases;Tuberculosis

ORG_CITY: NEW ORLEANS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Pediatric tuberculosis (TB) continues to pose diagnostic challenges in low- and middle-income countries with high rates of TB disease, due to the fact that children do not produce deep phlegm from the lungs used to detect TB in adults, and because sophisticated methods used in affluent countries are of limited usefulness due to cost, restricted availability, and poor sensitivity in children. Our team will evaluate a new diagnostic approach developed by Dr. Tony Hu at Tulane University that detects cell-free DNA from TB bacteria in a cohort of children with presumptive TV disease and age-matched controls children. We will also determine the correlation between cfDNA and quantitative imaging-based TB scores determined by chest X-ray and/or by lung ultrasound, markers that may combine with cfDNA levels to improve the detection of TB disease in children.

PI_NAMEs: GILMAN, ROBERT H;HU, TONY Y.;OBERHELMAN, RICHARD A (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Address;Adult;Age;Antibiotic Therapy;Area;automated algorithm;Automobile Driving;Bacteria;Biological Assay;Biological Markers;Blood specimen;Bolivia;cell free DNA;Cells;Chest;Child;Childhood;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;cohort;Collaborations;Computational algorithm;Computer Assisted;Consensus;Control Groups;cost;cost effective;Country;Cryopreservation;Detection;detection method;Development;Devices;Diagnosis;Diagnostic;diagnostic criteria;diagnostic platform;Diagnostic Procedure;diagnostic strategy;Diagnostic tests;diagnostic tool;Disease;DNA;Enrollment;Genes;genomic tools;Goals;Guidelines;Health Professional;High Prevalence;high risk;HIV;Household;Image;imaging biomarker;improved;innovation;Laboratories;low and middle-income countries;Lung;Lung Diseases;machine learning algorithm;Measures;Mediating;Methods;Molecular;Mycobacterium tuberculosis;Nature;novel;novel diagnostics;Organ;pathology imaging;Pediatric Hospitals;peripheral blood;Peru;Pilot Projects;point of care;Polymerase Chain Reaction;Population;portability;Predictive Value;prisma;Process;Proteomics;Pulmonary Pathology;quantitative imaging;Radiology Specialty;Rapid diagnostics;Reaction;Research;Resource-limited setting;Respiratory Disease;response;response biomarker;Risk;Serum;Specificity;Specimen;Sputum;study population;Subgroup;System;Techniques;Testing;Thoracic Radiography;Time;tool;treatment response;Tuberculosis;tuberculosis treatment;Ultrasonography;ultrasound;United States National Institutes of Health;Universities;Validation

PROJECT_TITLE: Diagnostic Innovations for Pediatric Tuberculosis in Bolivia

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Pediatric;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_NAME: ILIAD BIOTECHNOLOGIES, LLC

PHR: NARRATIVE: Live nasal recombinant B. pertussis vaccine against tuberculosis Effective tuberculosis vaccines that block infection and interrupt transmission of Mycobacterium tuberculosis from infected adolescents and adults are likely required to induce protective T cells in the lungs. Our vaccine strategy will advance a live vaccine platform comprised of an attenuated strain of Bordetella pertussis which has demonstrated ability to induce durable and specific mucosal and pulmonary T cell responses. We propose to develop the platform bacterial vector (called B-Tech-Mtb) for intranasal vaccination by expressing and secreting well characterized antigens of M. tuberculosis for induction of Th17 CD4+ and CD8+ T cell responses and test for efficacy in non-human primates after extensive characterization in murine models of infection.

PI_NAMEs: GOLDSTEIN, PETER  (contact);LOCHT, CAMILLE

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Adolescent;Adult;Animal Model;Antibodies;Antigens;Attenuated;Attenuated Vaccines;Bacteria;bacterial vector;Bordetella pertussis;CD8-Positive T-Lymphocytes;Cell Separation;Cells;Chimeric Proteins;Clinical;clinical development;clinical translation;clinically relevant;Codon Nucleotides;Complement;cost;Data;Dendritic Cells;Developing Countries;Development;Discrimination;DNA cassette;Dose;Effectiveness;efficacy testing;Freeze Drying;functional hypothalamic amenorrhea;Gene Modified;Genetic Engineering;Goals;Hemagglutinin;Human;Hybrids;IL17 gene;Immune response;Immunity;immunogenicity;Immunologics;Immunology;improved;Infant;Infection;Infrastructure;Interruption;Intranasal Administration;Laboratories;Lead;lead candidate;Lung;lung colonization;Lung infections;Macaca;Macaca fascicularis;Macaca mulatta;Manufacturer;Membrane;Modeling;mouse model;Mucosal Immune Responses;Mucous Membrane;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Nasopharynx;nonhuman primate;Nose;novel vaccines;Outcome;Papio;Parasites;parenteral administration;Peptide Hydrolases;Persons;Pertussis;Pertussis Vaccine;PET/CT scan;Phase;Phase II Clinical Trials;Positioning Attribute;Predisposition;prevent;Prevention;Production;programs;protective efficacy;Proteins;Publishing;Recombinants;response;Rhesus;Sampling;Secretory Immunoglobulin A;Serum;Site;Spleen;Structure of parenchyma of lung;Study models;success;System;T cell response;T-Lymphocyte;Techniques;Technology;Temperature;Testing;tissue resident memory T cell;Tissues;transmission process;Tuberculosis Vaccines;Type III Secretion System Pathway;Vaccination;vaccine candidate;vaccine distribution;vaccine evaluation;vaccine platform;Vaccine Production;vaccine strategy;vaccine trial;Vaccines;vector;Virulent;Virus;X-Ray Computed Tomography


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE The impact of autophagy on HIV infection and transmission remains to be elucidated. In this study, we will uncover the molecular interactions between autophagy and HIV. This knowledge has the potential to advance the HIV/AIDS field by identifying mechanisms that influence HIV pathogenesis and transmission, and can set the basis for new therapeutic approaches against HIV.

PI_NAMEs: SERRA MORENO, RUTH  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Affect;antagonist;Anti-viral Response;Antigen Presentation;APOCEC3G gene;Autophagocytosis;Autophagolysosome;Autophagosome;base;BCL2 gene;Binding;Cell Cycle Arrest;Cells;Data;Defect;Defense Mechanisms;design;Directed Molecular Evolution;Endoplasmic Reticulum;Endosomes;Event;gag Gene Products;Genetic Transcription;Goals;HIV;HIV Infections;HIV/AIDS;immune activation;Immune Evasion;Immune response;Impairment;improved;inhibitor;innovation;insight;Knowledge;Lysosomes;Maps;Mediating;Membrane;Messenger RNA;Modeling;Modification;Monoubiquitination;nef Genes;novel;novel therapeutic intervention;pandemic disease;Parkin;particle;pathogen;Pathogenesis;pathogenic virus;Pathway interactions;Pattern recognition receptor;Play;Post-Translational Protein Processing;Predisposition;prevent;Primate Lentiviruses;Production;Property;Proteins;Proviruses;Publishing;receptor;recruit;Reporting;Research;Resistance;RNA Splicing;Role;Structure;Testing;Therapeutic;transmission process;ubiquitin-protein ligase;Ubiquitination;Variant;Vesicle;Viral;Viral Drug Resistance;viral fitness;viral transmission;Virion;Virulence Factors;Virus;Virus Replication;Work

PROJECT_TITLE: New insights into the interplay between HIV and the autophagy machinery

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Violence Research;Women's Health Research

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Criminal justice-oriented policies enacted to protect newborns from prenatal substance exposure are associated with unintended negative consequences for both the mother and infant, suchas lower rates of maternal treatment utilization and higher rates of neonatal opioid withdrawal syndrome. Connecticut has implemented a unique policy strategy to support this population through early identification and assessment of mother-infant dyads. This proposed project applies a theory of health services utilization to examine this policy’s effect on three key outcomes: (1) maternal substance use treatment utilization, (2) child safety, and (3) racial disparities in child protective services referrals.

PI_NAMEs: SIEGER, MARGARET LLOYD (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Address;administrative database;adverse outcome;Affect;Amendment;Award;Birth;Black race;career development;Caring;Cause of Death;Child;Child Abuse and Neglect;Child abuse prevention;child protection;child protective service;Child Rearing;Child Welfare;Clinical;Collaborations;Communities;Complex;Connecticut;Criminal Justice;Data;Data Analyses;Data Collection;Data Set;Data Sources;Development Plans;Diagnosis;Early identification;Ensure;Epidemiology;ethnic disparity;experience;Family;family support;fetal substance exposure;foster care;Foundations;genetic linkage analysis;Health;health care service utilization;Health Personnel;Health Policy;health service use;high risk;Home;Hospitals;improved;improved outcome;Indigenous;Infant;Infant Health;Infrastructure;innovation;Intervention;Intervention Studies;Justice;Lead;Link;Longitudinal Surveys;Masks;Maternal Health Services;maternal outcome;Mentored Research Scientist Development Award;Mentorship;minority children;Modeling;Mothers;multidisciplinary;multilevel analysis;National Institute of Drug Abuse;Neonatal Abstinence Syndrome;Newborn Infant;opioid overdose;Outcome;Perinatal;perinatal women;Policies;Policy Research;Population;Population Heterogeneity;Positioning Attribute;Pregnancy;pregnant;prevent;Prevention Research;Productivity;programs;Provider;Public Health;Public Policy;racial disparity;Records;recruit;referral services;Research;Research Personnel;Research Priority;response;Risk;Role;Safety;safety outcomes;secondary analysis;service intervention;Services;Site;Statistical Methods;substance use;Substance Use Disorder;substance use treatment;System;Testing;theories;Time;Training;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Public Policy & Health for Substance Exposed Infant-Mother Dyads

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Regenerative Medicine

ORG_CITY: PORTLAND

ORG_DEPT: DENTISTRY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: The OHSU SOD is uniquely positioned to offer this comprehensive research mentoring and training PORT for the next generation of oral health scientists since we are the only dental school in the state of Oregon, supported by robust OHSU and state-wide research and research training resources. We are committed to address current and future shortages in the oral health research workforce by preparing a diverse and inclusive cadre of individuals for careers as independent scientists. Our objective is consistent with NIDCR’s mission to advance national research needs in the dental, oral and craniofacial health and science.

PI_NAMEs: WU, HUI  (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Acceleration;Address;Award;Basic Science;Biocompatible Materials;career;Clinical Research;Creativeness;Dentists;design;Doctor of Philosophy;Education;Educational workshop;Effectiveness;Environment;Event;experience;Fellowship;Funding;graduate student;Grant;Health;innovation;Institution;interdisciplinary approach;interest;Knowledge;Leadership;Master of Science;matriculation;Mentors;Mentorship;microbial;National Institute of Dental and Craniofacial Research;Oral health;Oregon;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Public Speaking;Qualifying;Recording of previous events;Regenerative Medicine;Research;Research Personnel;Research Training;School Dentistry;Schools;Science;Scientist;Series;Structure;Students;Tissue Engineering;Training;training opportunity;Training Programs;Translational Research;undergraduate research experience;undergraduate student;United States National Institutes of Health;Universities;Visit;workforce needs;Writing

PROJECT_TITLE: PORT (Portland Oral health Research Training)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DENVER

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF DENVER (COLORADO SEMINARY)

ORG_STATE: CO

PHR: PROJECT NARRATIVE Disruptions to oxygen homeostasis underlie many devastating human diseases including heart, lung, and cerebrovascular disease, as well as chronic conditions that afflict those living at high altitudes above 2500 meters. Using a combination of controlled-laboratory and semi-wild field studies, my lab will exploit natural variation in populations of the North American Deer Mouse, a species with broad elevational distribution, as a means to dissect the genetic and molecular mechanisms by which natural selection reshapes physiology in the process of adaptation to high altitude. The large-scale and ambitious series of experiments outlined in this proposal will yield new insights into high-altitude biology and medicine and may lead to novel therapeutic targets for diseases in which the disruption of oxygen homeostasis is central to their pathology.

PI_NAMEs: VELOTTA, JONATHAN PAUL (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Acute;Altitude;Altitude Sickness;American;Animals;Biology;Blood Viscosity;Cerebrovascular Disorders;Cessation of life;Chronic;Coupled;Deer Mouse;Disease;experimental study;Exposure to;field study;Functional disorder;Genetic;genetic architecture;genome resource;Health;Heart;Heart Diseases;Heart failure;Homeostasis;Human;human disease;Hypoxia;insight;Laboratories;Lung;Lung Diseases;Maintenance;Medicine;meter;Modeling;Molecular;Natural Selections;Network-based;new therapeutic target;North America;Oxygen;Pathology;Peromyscus;Persons;Physiological;Physiology;Population;Pregnancy Outcome;Process;Quantitative Genetics;Regulatory Pathway;response;Series;Shapes;Testing;Time;trait;transcriptome sequencing;transcriptomics;Variant

PROJECT_TITLE: Physiological plasticity and the mechanisms of adaptation to hypoxia: exploiting natural variation in wild deer mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SAN ANTONIO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative Persons with good brain health at the beginning of old age may be able to protect themselves from the development of dementia. Brain health is typically measured using brain imaging and cognitive tests. We are proposing a new way of capturing brain health – by assessing “sensory- motor” function using measurements of smell, vision, hearing, gait, touch and balance using non-invasive tests. These changes are typically considered part of normal aging, but recent research has shown that these could be early warning signs of dementia. In this study, we will examine how brain health measured using these sensory-motor measures can predict protection from or risk for dementia and increase our understanding of the many genetic and lifestyle, vascular factors that determine sensory-motor brain health.

PI_NAMEs: KASHANI, AMIR H;RAMACHANDRAN, VASAN S;SESHADRI, SUDHA  (contact);WELLING, D BRADLEY

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: African American population;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid;Anisotropy;Auditory;Autopsy;Behavioral;Biological Markers;Biology;Blood;Blood Glucose;Blood Vessels;blood-based biomarker;bone mass;Brain;brain health;Brain imaging;brain magnetic resonance imaging;Brain Pathology;Brain-Derived Neurotrophic Factor;cerebral atrophy;cerebrovascular;Chronology;circulating biomarkers;Clinic;Clinical;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive reserve;cognitive testing;cohort;Cohort Studies;Data;Dementia;dementia risk;Development;Diet;Dimensions;Disease;Disparate;DNA Methylation;early detection biomarkers;Early Diagnosis;Education;Educational workshop;endophenotype;epidemiology study;epigenetic aging;Equilibrium;European;European ancestry;Evaluation;Event;executive function;experience;follow-up;Fracture;Framingham Heart Study;Funding;Gait;Genetic;genetic predictors;Genetic Predisposition to Disease;genetic variant;Genomics;Grant;gray matter;health assessment;Hearing;Heart;Hippocampus;Hispanic;Hispanic ancestry;human old age (65+);IGF1 gene;Image;indexing;Individual;Injury;insight;Italy;Life;Life Style;Lipids;Magnetic Resonance Imaging;Marital Status;Measurement;Measures;Memory;Metabolic;Mexican Americans;mild cognitive impairment;mortality;Motor;motor disorder;Nervous System Disorder;Neurologic;Neurological status;normal aging;Occupations;offspring;older adult;Osteoporosis;Outcome;Participant;Pathogenesis;Pathology;Pattern;Perception;personalized risk prediction;Persons;Phase;Phenotype;Physical activity;Play;Population;Positron-Emission Tomography;pre-clinical;predictive marker;prevent;Proteins;Proteomics;Research;resilience;Resistance;Retina;Risk;Risk Factors;Risk Marker;risk stratification;Role;Sampling;sensorimotor system;Sensory;Sleep;Smell Perception;social;Social Network;Stroke;stroke outcome;Structure;sulfated glycoprotein 2;Tactile;tau Proteins;Testing;Texas;Therapeutic Intervention;Touch sensation;Transient Ischemic Attack;vascular cognitive impairment and dementia;Vascular Endothelial Growth Factors;vascular factor;Vestibular function;vestibular system;Vision;Visual;Water;White Matter Hyperintensity

PROJECT_TITLE: Multidimensional Assessment of Brain Health as A Marker of Dementia Risk and Resilience

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(56)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Hearing Loss;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Narrative During the critical search for drugs to treat COVID-19 patients, it’s important to select drugs with maximum antiviral efficacy and minimal side-effects. Using a combination of computer modeling and animal studies, we will test the potential for COVID-19 therapies to cause hearing loss; a side-effect of many drugs not often detected during clinical trials. Our goal is to help develop safer COVID-19 therapies.

PI_NAMEs: COFFIN, ALLISON B (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Adult;Animals;anti-viral efficacy;Auditory;Azithromycin;Biological Assay;Biometry;Blood;Case Study;Categories;Cause of Death;Chemical Structure;Clinical;Clinical Trials;Cochlea;combat;Computer Models;computer scientist;cost;COVID-19;COVID-19 patient;COVID-19 screening;COVID-19 therapeutics;COVID-19 treatment;cytotoxic;cytotoxicity;Data;Data Set;Databases;Detection;Development;Disease;drug candidate;Drug Combinations;drug development;Drug usage;experimental study;FDA approved;feature selection;Goals;Hair Cells;hearing impairment;Hearing Tests;Human;Human Resources;Hydroxychloroquine;Immune response;Immune system;in silico;In Vitro;in vivo;Individual;Infection;Inner Hair Cells;innovation;Intervention;Ivermectin;Labyrinth;lateral line;Life;Link;Machine Learning;machine learning model;Methods;Modeling;Molecular;Monitor;Morphology;novel;novel therapeutics;older patient;Organ;otoprotectant;ototoxicity;ototoxin;pandemic disease;Patient Monitoring;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Physiological;Physiology;Positioning Attribute;pre-clinical;Preclinical Testing;preservation;Principal Component Analysis;Public Health;Publishing;rapid detection;Rattus;Reporting;Research;research clinical testing;response;Risk;Ritonavir;screening;Sensory;Sensory Hair;severe COVID-19;side effect;Stavudine;Supporting Cell;Synapses;System;systemic inflammatory response;Testing;Therapeutic;Therapeutic Uses;Toxic effect;training data;Treatment Efficacy;Vaccination;Work;Zebrafish

PROJECT_TITLE: Determining the ototoxic potential of COVID-19 therapeutics using machine learning and in vivo approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-B(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Alcohol is the most commonly abused substance in the US and Alzheimer’s disease is the most common neurodegenerative disease; recent evidence indicates that alcohol abuse increases the risk for developing Alzheimer’s disease and accelerates disease trajectory. Our novel pilot studies indicated that chronic, intermittent alcohol consumption increased mitochondrial oxidant stress in locus coeruleus axons and increased Alzheimer’s related pathology in a mouse model of Alzheimer’s disease. Our proposal is aimed at understanding the effect of chronic, intermittent alcohol consumption on mitochondria in locus coeruleus neurons and how this impacts neurodegeneration and Alzheimer’s related pathology.

PI_NAMEs: GRAVES, STEVEN MICHAEL (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: abeta deposition;Abstinence;Acceleration;Age;alcohol abstinence;Alcohol abuse;Alcohol consumption;Alcohols;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;APP-PS1;Attenuated;Axon;beta amyloid pathology;Binding;Biosensor;Brain;Brain Stem;Cell Nucleus;Chronic;chronic alcohol ingestion;Clinical;comparison control;Data;Dependence;Development;Disease;Disease Progression;drinking water;druggable target;Electron Transport;Electrons;Enzymes;experimental study;Fluorescent in Situ Hybridization;Genetic;genetic approach;Genetic Techniques;Glutamates;Heavy Drinking;high risk;Hippocampus;Immunohistochemistry;Impairment;inhibitor;Knock-in Mouse;Laser Scanning Microscopy;Lesion;locus ceruleus structure;Measures;Mediating;Messenger RNA;Metabolism;mild cognitive impairment;Mitochondria;Mitochondrial Matrix;monoamine;Monoamine Oxidase;Monoamine Oxidase Inhibitors;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;neuroprotection;Neurotransmitters;Norepinephrine;novel;Outcome;oxidant stress;Oxidation-Reduction;Pathogenesis;Pathology;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phenelzine;Pilot Projects;pre-clinical;problem drinker;Process;Proteins;Public Health;Risk;Risk Factors;Role;Slice;Testing;Transcript;two-photon;Vesicle;vesicular monoamine transporter 2;Western Blotting

PROJECT_TITLE: Chronic alcohol-induced mitochondrial oxidant stress and Alzheimer's related pathogenesis


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Mental Health;Patient Safety;Pediatric;Suicide

ORG_CITY: Newark

ORG_DEPT: PEDIATRICS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: This proposal takes advantage of existing data to examine the chance for serious, life-threatening harms to occur in children who take medicines such as antidepressants and anti-seizure drugs that are not approved or proven to treat their medical conditions or children their age. The information from this research will help clinicians, families, and patients to make more informed decisions about using these kinds of medicines, including the identity of higher-risk subgroups and safer alternatives for treatment.

PI_NAMEs: HORTON, DANIEL BENJAMIN (contact)

PROGRAM_OFFICER_NAME: TAYLOR-ZAPATA, PERDITA

PROJECT_TERMS: Adult;Adverse effects;Age;age group;alternative treatment;anti-depressive agents;anti-epileptic agents;Antibiotics;Anticonvulsants;Arrhythmia;Biology;Biometry;Bupropion;Cardiology;Child;Child Health;Child Psychiatry;Childhood;Clinical;clinical decision-making;clinical practice;Clinical Trials;clinically relevant;Controlled Study;Data;Data Sources;Databases;Dermatology;Diagnosis;Disease;Dose;Drug Combinations;drug efficacy;Drug Interactions;Drug usage;Effectiveness;Electronic Health Record;Escitalopram;evidence base;Family;FDA approved;Feasibility Studies;Fluoxetine;gabapentin;Goals;Health Insurance;Heart Arrest;high risk;improved;Intervention Trial;Label;lamotrigine;Life;Link;Literature;Medicaid;Medical;medication safety;Medicine;Mood stabilizers;mortality risk;Nonpharmacologic Therapy;off-label drug;off-label use;Outcome;Outcome Measure;Patients;Pharmaceutical Preparations;Pharmacoepidemiology;Polypharmacy;Population;Prevalence;programs;Psychotropic Drugs;Reaction;Research;Retrospective cohort;Risk;Safety;Sample Size;Skin;Subgroup;Sudden Death;suicidal morbidity;suicidal risk;Suicide;Therapeutic;Time;Translating;United Kingdom;United States;valproate;venlafaxine;Ventricular Arrhythmia;Work

PROJECT_TITLE: Safety of Drugs Commonly Used Off-Label in Children Despite Insufficient Evidence of Efficacy and Safety

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Although microglia proliferation plays critical roles in the development of many neurological diseases, its mechanism is largely unknown. Our preliminary studies suggest that adult microglia proliferation has a Myc- dependent initiation phase and a Myc-independent maintenance phase. We now propose a set of experiments to further delineate the mechanism of microglia proliferation.

PI_NAMEs: GUAN, ZHONGHUI  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Adult;Afferent Neurons;Alzheimer's Disease;Cell Differentiation process;cellular imaging;Color;CSF1R gene;Development;Down-Regulation;Embryo;experimental study;Fluorescence;Gene Expression Profile;Genes;Immunohistochemistry;Infection;Infiltration;injured;irradiation;Lumbar spinal cord structure;Macrophage Colony-Stimulating Factor;Maintenance;Maps;Membrane Proteins;Mental disorders;Microglia;Modeling;monocyte;Motor Neurons;mouse model;Multiple Sclerosis;neonate;nerve injury;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;Newborn Infant;Optic Nerve Injuries;overexpression;Pathway interactions;Pattern;Peripheral nerve injury;Phase;Phosphorylation;Play;Population;prevent;Proliferating;Proliferation Marker;Protein Tyrosine Kinase;Proto-Oncogene Proteins c-myc;Quantitative Reverse Transcriptase PCR;Regulation;RiboTag;Role;sciatic nerve injury;Seizures;self-renewal;Signal Pathway;single-cell RNA sequencing;Sorting;spinal cord and brain injury;Stroke;System;Testing;Time;transcription factor;Transcriptional Regulation;TREM2 gene;TYROBP gene;Up-Regulation

PROJECT_TITLE: Mechanism of microglia proliferation

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PUBLIC HEALTH RELEVANCE Extension and enhancement of the SCCS, a unique and comprehensive resource, will enable population-based research into the determinants of cancer risk and outcome among African Americans, assessment of disparities among vulnerable and disadvantaged groups, and expansion of the information base for the development of strategies aimed at reducing the burden of cancer among all segments of the US population. 1

PI_NAMEs: BLOT, WILLIAM J.;SHRUBSOLE, MARTHA J.;ZHENG, WEI  (contact)

PROGRAM_OFFICER_NAME: DELLAVALLE, CURT TAVIS

PROJECT_TERMS: Adult;African American;African American population;Age;American;base;Biological;Biological Specimen Banks;Black Populations;Blood;Cancer Burden;cancer health disparity;cancer prevention;cancer risk;career;Cessation of life;Chronic Disease;cohort;Cohort Studies;Collection;Communities;Data;Databases;design;Development;digital;Disease;Disease Outcome;Disparity;Disparity population;DNA;Education;Educational Status;Enrollment;Epidemiology;epidemiology study;Etiology;Evaluation of Cancer Risk Factors;Event;experience;follow-up;Funding;Genomic DNA;Grant;gut microbiome;Health;health determinants;health disparity;Health Services;Health Status;Histology;Incidence;indexing;Inequity;Information Systems;Infrastructure;innovation;Institution;interest;Investigation;Investments;Low income;Malignant Neoplasms;Medicaid;Medicare;member;microbiome research;Neighborhood Health Center;neoplasm registry;Not Hispanic or Latino;Oral cavity;Outcome;Paper;Participant;Patient Self-Report;Population;Population Research;Preventive service;public health relevance;Publishing;Quality Control;Race;Recontacts;Recording of previous events;recruit;Registries;Reporting;repository;Research;Research Personnel;research study;Resource Sharing;Resources;Risk;Rural;rural area;rurality;Saliva;sample collection;Sampling;social;Socioeconomic Status;stool sample;Subgroup;Surveys;Tissue Banks;Tumor Tissue;underserved area;Underserved Population;United States;United States Social Security Administration;Update;urban area;Urine;Vulnerable Populations

PROJECT_TITLE: Southern Community Cohort Study

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: HL

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Gene Therapy;Genetics;Infectious Diseases;Influenza;Lung;Nanotechnology;Pneumonia and Influenza;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative This research will contribute to our ability to use precision/nano- medicine to target vascular and fibrotic diseases in the lung by performing cell-type specific disease modification. Application of this knowledge has the potential to treat many other diseases which are thought to propagate through specific cell populations.

PI_NAMEs: TIRRELL, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: 2019-nCoV;Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Alveolar;Alveolus;Animal Experiments;Autopsy;Bleomycin;Blood Vessels;Cause of Death;cell type;Cells;Chicago;Chronic;Chronic lung disease;Cicatrix;Community Medicine;Complication;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19/ARDS;Critical Illness;cytokine release syndrome;Data;Disease;Encapsulated;endoplasm;endothelial dysfunction;Endothelium;Engineering;Fibroblasts;fibrotic lung;Fright;gene delivery system;Genetic;Goals;Health;high risk;Human;immunogenicity;Impairment;in vivo;in vivo evaluation;Infection;Inflammatory;inflammatory lung disease;Influenza;Knowledge;Lung;Lung Diseases;lung injury;Medical;Messenger RNA;Modification;Molecular;Molecular Profiling;Molecular Target;Morbidity - disease rate;mortality;Mus;nanomedicine;nanoparticle;overexpression;pandemic influenza;Patients;Peptides;Perfusion;Pharmacological Treatment;Phase;Plasmids;Platelet-Derived Growth Factor beta Receptor;Population;Process;Protein Disulfide Isomerase;protein expression;Proteins;Public Health;Publishing;Pulmonary Fibrosis;pulmonary function;Pulmonary Inflammation;Research;Reticulum;Risk;RNA vaccine;short hairpin RNA delivery;Slice;small hairpin RNA;Stimulus;Testing;Therapeutic;Therapeutic Effect;therapeutic effectiveness;therapeutic evaluation;Tidal Volume;transcription factor;TXN gene;Universities;Uridine;Vascular Cell Adhesion Molecule-1;Vascular Endothelial Cell;vascular endothelial dysfunction;ventilation;Viral;Viral Physiology;Viral Pneumonia;Virus;Water;Work

PROJECT_TITLE: Targeted Gene Delivery Systems Treating Lung Diseases

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative: The proposed research is relevant to public health because some of the mutated mice under investigation in this study will identify genes and mechanisms that cause human neurodevelopmental disorders such as neural tube defects, cephalic disorders, and intellectual disability. The outcomes will be relevant to the mission of NICHD to understand early human development and improve child health. The fundamental knowledge gained will impact many fields of biology and medicine.

PI_NAMEs: DWYER, NOELLE D (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Address;Affect;Age;Apical;apical membrane;Apoptosis;Axon;Basal lamina;base;Biological;Biology;Body Size;Brain;brain abnormalities;Brain Diseases;brain malformation;brain size;Candidate Disease Gene;Cell division;Cell Polarity;Cells;Cellular Structures;Cephalic;Child Health;cohort;Communities;comparison control;Complex;Cytokinesis;Data;Databases;Daughter;daughter cell;Defect;Development;Developmental Biology;developmental disease;Disease;disease model;Dissection;Embryo;Ethylnitrosourea;Etiology;Excision;experience;forward genetics;gastrulation;gene discovery;Gene Expression;gene function;Genes;Genetic;genetic approach;Goals;Heterozygote;Histologic;Histology;Histopathology;Homozygote;Human;Human Development;Image;improved;inner ear development;insight;Intellectual functioning disability;International;Investigation;Kinesin;Kinetics;Knock-out;Knockout Mice;Knowledge;Labyrinth;Lead;Libraries;Medicine;Methods;Microtubules;Mission;Mitosis;Modeling;Morphogenesis;Morphology;mouse genetics;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;National Institute of Child Health and Human Development;nerve stem cell;neural plate;Neural Tube Defects;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;neuromechanism;novel;Organ;organ growth;Outcome;Phenotype;Placenta;Process;Proliferating;Prosencephalon;Proteins;Public Health;Publishing;Research;Research Personnel;Resources;response;reverse genetics;Role;self-renewal;Series;Shapes;Simple Epithelium;Spinal Cord;Stains;stem cell division;Stretching;Structural defect;Structure;Surface;Testing;Thick;Time;tool;Tube;Ventricular

PROJECT_TITLE: Brain development phenotyping of IMPC lethal mutant mice

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ORG_DEPT: BIOCHEMISTRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The purpose of the Biochemistry, Cellular and Molecular Biology Graduate Program is to train outstanding scientists for diverse careers in biomedical research. This goal is achieved through a rigorous, broad-based curriculum and independent research in a basic science laboratory. This type of training is essential for understanding human disease at a fundamental level, and allows our students to enter the biomedical workforce where they contribute to breakthroughs in biology and medicine.

PI_NAMEs: INOUE, TAKANARI  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Biochemistry and Cellular Biology;Molecular Biology;programs

PROJECT_TITLE: Biochemistry, Cellular and Molecular Biology Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Exposure of blood plasma/serum (P/S) biospecimens to temperatures above their freezing point of -30 °C can dramatically impact clinical research results—a phenomenon that has been shown to produce inordinate numbers of false leads in biomedical research. Well over 100 NIH-sponsored extramural grants employ pre- existing P/S—yet, surprisingly, no criteria for establishing pre-existing sample integrity have been set and no quality thresholds exist that must be met before NIH/NCI (taxpayer) funds are spent on studies involving pre- existing P/S. This project will develop and analytically validate simple plate reader-based assays based on established ex vivo biochemistry that will put the means to assess P/S integrity in the hands of nearly every biomedical research scientist—making it possible for governing bodies to require evidence-based quality control of P/S samples employed in biomedical research.

PI_NAMEs: BORGES, CHAD R (contact)

PROGRAM_OFFICER_NAME: KOHAAR, INDU

PROJECT_TERMS: Adoption;Age;Agreement;Albumins;Aliquot;anti-cancer research;Archives;Award;Biochemistry;Biological Assay;Biological Markers;Biomedical Research;blind;Cancer Patient;cell free DNA;Clinical Research;clinically relevant;Collection;Consumption;cost;Cysteine;Cystine;Data;Development;Disclosure;Disease Marker;Disulfides;epigenetic marker;Event;evidence base;Exhibits;exposed human population;Exposure to;Extramural Activities;field study;Fluorescence;Forensic Medicine;Freezing;Funding;Funding Agency;Gender;Generations;Goals;Grant;Human;Incentives;Incubated;Individual;instrument;Journals;Laboratories;Laws;Legal patent;Link;Liquid substance;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;Measurement;meter;Minor;Molecular Weight;novel;Paper;Patients;Performance;Plasma;Population;population survey;pre-clinical;pre-clinical research;Preparation;programs;Proteins;Publishing;Quality Control;Race;rapid test;Reader;Recording of previous events;Reporting;Research;Research Personnel;Running;Sampling;Science;Scientist;Serum;small molecule;Specimen;Spottings;success;Sulfhydryl Compounds;Temperature;Time;Tissue Inhibitor of Metalloproteinase-1;tool;Trifluoroacetic Acid;United States National Institutes of Health;Validation;Vascular Endothelial Growth Factors;weapons of mass destruction;Work

PROJECT_TITLE: Plate reader assays to forensically assess exposure of plasma and serum to thawed conditions


NIH_SPENDING_CATS: Behavioral and Social Science;Mental Health;Neurosciences;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Environmental Neuroscience for All will combine online and in-person tools to support authentic research experiences for socio-culturally diverse student teams from both urban and rural schools across the US, who will work with scientists and civic partners to design studies that explore the relationship between our brains and our environment (How is our brain health and wellbeing affected by our environment? Can we help improve how we behave toward our environment by deepening our understanding of how the human brain is wired?). The curriculum, paired with an online collaboration platform and professional development materials, will cover topics that are tightly linked to NIH-funded research (How do environmental factors affect brain health? How might behavioral science contribute to public health policy?). Moreover, the program uses an “open science” and participatory science approach, training the next generation of scientists and citizens to view environmental challenges not just as barriers, but as opportunities for research, innovation, and collaboration.

PI_NAMEs: DIKKER, SUZANNE  (contact);MATUK, CAMILLIA F

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Affect;Behavior;Behavioral Sciences;Brain;brain health;Case Study;citizen science;cognitive neuroscience;Collaborations;Communication;Communities;community organizations;community partners;community science;Consumption;Data Analyses;Data Collection;data communication;design;Development;Distance Learning;Education;Educational Curriculum;Educational process of instructing;Environment;Environmental Risk Factor;Environmental Science;Ethics;experience;Familiarity;Feedback;flexibility;Foundations;Funding;Generations;Geography;Health Policy;high school;High School Student;Human;Hybrids;ideation;improved;innovation;Knowledge;Learning;Link;literacy;Mediation;meetings;Mentors;Mentorship;Methods;Molecular Biology;Multimedia;Neurosciences;Neurosciences Research;next generation;open data;Participant;Pathway interactions;peer;Peer Group;Peer Review;Personal Satisfaction;Persons;Play;programs;Public Health;Research;Research Design;Research Methodology;Research Project Grants;research study;Role;role model;Rural;Schools;Science;Scientist;social;social culture;social neuroscience;socioeconomics;STEM career;STEM field;Students;support tools;teacher;Technology;Teenagers;Time;tool;Training;Translating;United States National Institutes of Health;virtual;web platform;Work

PROJECT_TITLE: Environmental Neuroscience for All: A participatory science program and platform for students, teachers, scientists, and communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: STONY BROOK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Breast cancer (BC) is a leading cause of cancer deaths in women in the U.S. and worldwide. BC remains refractory to many treatment options; hence, new therapeutic modalities are urgently needed. The specific goals of this application are 1) to investigate how alkaline ceramidase 2 (ACER2), a newly identified target of DNA- damaging chemotherapeutic agents in mediating cancer chemoresistance, metastasis, and recurrence; and 2) to develop novel approaches to overcoming BC chemoresistance and chemotherapy-induced metastatic recurrence by targeting ACER2.

PI_NAMEs: MAO, CUNGUI  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Adjuvant Chemotherapy;advanced breast cancer;angiogenesis;Apoptosis;Bone Marrow;Brain;Breast;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Risk Factor;Breast Cancer therapy;Cancer Etiology;Cancer Model;cancer stem cell;Cell Death;Cell Proliferation;Cell Survival;Cells;Ceramidase;Ceramides;Cessation of life;Chemoresistance;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;Circulation;Clinical;Clinical Management;combinatorial;Data;DNA Damage;Dose;Down-Regulation;Doxorubicin;Eligibility Determination;Family;Fatty acid glycerol esters;Future;Genes;genotoxicity;Goals;Homeostasis;Hydrolysis;Immune response;improved;inflammatory breast cancer;inhibitor;Ionizing radiation;Knockout Mice;Lipids;Liver;Lung;Lymphangiogenesis;Malignant Breast Neoplasm;Malignant Neoplasms;Mammals;mammary;Mammary Gland Parenchyma;Mediating;member;Metastatic Neoplasm to the Lung;Metastatic/Recurrent;Modality;Molecular;mouse alkaline ceramidase;mouse model;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Peripheral;Phosphorylation;pre-clinical;Proliferating;Publishing;Recurrence;Refractory;restraint;Role;Saccharomyces cerevisiae;Scheme;Site;small molecule inhibitor;Sphingosine;sphingosine 1-phosphate;sphingosine kinase;stem cell survival;Testing;Therapeutic;Tissues;TP53 gene;Treatment Efficacy;tumor;Tumor Angiogenesis;tumor growth;Tumor Promotion;tumorigenic;Up-Regulation;Women's mortality;Yeasts

PROJECT_TITLE: Role of ACER2 in cancer chemoresistance and metastasis

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ORG_CITY: DURHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The proposed studies will discover MED31-driven transcription recycling as a novel oncogenic mechanism contributing to progression of lethal castration-resistant prostate cancer (CRPC). Our studies will yield detailed molecular insight into the control of aberrant transcription recycling in lethal prostate cancer, while performing preclinical development of a CRISPR/Cas13d RNA targeting-based nanotherapy targeting MED31-mediated transcription recycling in CRPC.

PI_NAMEs: WANG, QIANBEN  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Amino Acids;androgen independent prostate cancer;Androgen Receptor;aptamer;Biochemical;Biological Assay;Biological Process;bone;cancer cell;Cancer Cell Growth;Cancer Patient;Castration;Cell Culture Techniques;Cells;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Disease;DNA;domain mapping;Drug Design;European;Future;gene-targeted therapy;Genes;Genetic Transcription;Genomics;Growth;Guide RNA;human tissue;Immunohistochemistry;improved;In Vitro;in vivo;insight;Invaded;knock-down;Legal patent;lipid nanoparticle;lymph nodes;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;Mediator;Messenger RNA;Metastatic Neoplasm to the Liver;Modeling;Molecular;Mus;nanoparticle;nanotherapy;Neoplasm Metastasis;new therapeutic target;Non-Visceral;novel;Nucleic Acids;Oncogenic;Organ;Outcome;Output;patient derived xenograft model;Patients;Phase;Polymerase;preclinical development;Process;Prognosis;Prostate;prostate cancer cell;prostate cancer cell line;prostate cancer progression;protein expression;Proteins;Proteomics;Receptor Inhibition;Receptor Signaling;Recycling;Resistance;response;RNA;RNA Polymerase II;Role;Safety;Sampling;small molecule;Specificity;Surface;System;targeted agent;targeted delivery;targeted treatment;Testing;Therapeutic;Tissue Microarray;Tissues;Toxic effect;Transcription Elongation;Transcription Initiation;Transcription Process;Treatment Efficacy;tumorigenesis;Xenograft procedure

PROJECT_TITLE: Targeting MED31-driven transcription recycling in lethal prostate cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-C(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_STATE: TX

PHR: PROJECT NARRATIVE This proposal is designed to train Dr. Margaret Flanagan in formal epidemiologic and translational research approaches to enable her to become an independently funded physician-scientist studying dementia and aging. Trans-active response DNA-binding protein 43 (TDP43) has been previously shown to be associated with increased levels of inflammatory markers and may serve as a modulator of inflammation, yet it remains unclear what is detrimental vs. beneficial in the increasingly prevalent disease entity: Limbic predominant age related TDP43 encephalopathy (LATE). Results from this work will provide insight for development of future therapeutic strategies targeting TDP43 associated neuroinflammation.

PI_NAMEs: FLANAGAN, MARGARET E (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Abeta clearance;Address;Age;age related;Aging;alpha synuclein;Alzheimer's Disease;Amyloid beta-Protein;Astrocytes;Autopsy;Award;Binding Proteins;Biological Markers;biomarker identification;Brain;care outcomes;career development;Cause of Death;Cd68;Cell Nucleus;Cell Physiology;Clinic;Clinical;Clinical Data;Clinical stratification;cognitive performance;cohort;Cytoplasm;Data;Dementia;dementia risk;dentate gyrus;design;Development;Development Plans;disability;Disease;Disease Progression;DNA-Binding Proteins;Epidemiology;epidemiology study;experience;Frontotemporal Dementia;Funding;Future;gene product;Genetic Risk;Genomics;Goals;hippocampal sclerosis;Imaging technology;Immune;Impaired cognition;improved;in vivo;Inflammation;Inflammatory;inflammatory marker;insight;interest;K-Series Research Career Programs;Knowledge;Label;Laboratories;late life;Late Onset Alzheimer Disease;Leadership;Lesion;limbic-predominant age-related TDP-43 encephalopathy;Medicine;Mentors;Mentorship;Microglia;mild cognitive impairment;Minnesota;multidisciplinary;Multiplexed Ion Beam Imaging;Nerve Degeneration;Nervous System Disorder;Neurofibrillary Tangles;Neuroglia;neuroinflammation;neuron loss;Neurons;neuropathology;NF-kappa B;novel therapeutic intervention;Nuclear;Outcome;Pathologic;Pathology;Pathway interactions;Phenotype;Physicians;Play;preventive intervention;programs;protein TDP-43;Proteins;Regulation;Research;Research Personnel;Resolution;response;risk variant;RNA Processing;Role;Sampling;Scientist;Senior Scientist;skills;Structure;Synapses;Therapeutic;Therapeutic Intervention;Time;Training;transcription factor;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: nvestigating the role of neuroinflammation in Limbic-predominant age related TDP43 encephalopathy

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Cystic Fibrosis;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Orphan Drug;Pneumonia and Influenza;Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Viral lung infection is a major cause of severe lung injury and death. This proposal aims to gain new understanding of how viruses, specifically influenza, cause lung injury, with the overall goal of identifying new treatment approaches that decrease lung injury and increase survival. The ongoing COVID-19 pandemic and threat of future pandemics by other viruses, including influenza, give special importance to this research.

PI_NAMEs: HOOK, JAIME LYNN (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Accounting;Acute Lung Injury;Address;Adult;Air;Alveolar;alveolar epithelium;Alveolar wall;Alveolus;Anatomy;Apical;aqueous;Bacteria;Bioenergetics;Catalytic Domain;Cell Culture Techniques;Cells;Cessation of life;Child;co-infection;Complex;Confocal Microscopy;COVID-19 pandemic;Critical Illness;Cultured Cells;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Death Rate;Defense Mechanisms;Edema;Enzymes;Epithelium;Excess Mortality;Film;future pandemic;Goals;Hemolysin;Hospitalization;Hour;Human;Image;In Situ;In Vitro;Influenza;Influenza A virus;influenza infection;Inhalation;inhibitor;insight;Ion Channel;knock-down;Leucine;Lipids;Liquid substance;Lung;Lung infections;lung injury;Measures;Mediating;Membrane;Membrane Proteins;Methods;Methylation;Methyltransferase;Mission;Modeling;Molecular;mortality;mouse model;Mus;mutant;National Heart, Lung, and Blood Institute;new therapeutic target;novel therapeutic intervention;pandemic virus;particle;Particle Size;Pathogenesis;Pathologic;Patients;Persons;Pharmaceutical Preparations;Phosphoric Monoester Hydrolases;Phosphorylation;Physiology;plasmid DNA;Population;Positioning Attribute;prevent;protective effect;Protein Dephosphorylation;Protein phosphatase;Proteins;Pulmonary alveolar structure;Pulmonary Edema;real-time images;Research;Resistance;Respiratory Failure;response;restoration;Role;secondary infection;Secondary to;Small Interfering RNA;Staphylococcus aureus;Staphylococcus aureus infection;Structure;success;Surface;Testing;therapeutic evaluation;Time;Toxin;Transgenic Mice;United States;Viral;Viral Interference;Virus;Wild Type Mouse

PROJECT_TITLE: Alveolar responses to viral lung infection

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative We will be studying the neural circuits in the brain that integrate and process complex sensory information to guide natural behaviors. These studies will have applicability to psychiatric disorders that involve deficits in sensory integration, such as schizophrenia and autism spectrum disorders. They will also provide insight into the cognitive deficits seen in pathological conditions such as Alzheimer’s disease and Parkinson’s disease.

PI_NAMEs: GIRE, DAVID HENRY (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: 3-Dimensional;Air Movements;Algorithms;Alzheimer's Disease;Animal Behavior;Animals;Area;autism spectrum disorder;Automobile Driving;Behavior;behavior test;Behavioral;behavioral response;Biological Models;Brain;Calcium;calcium indicator;Cells;Chronic;Code;Cognitive deficits;Complex;Computer Models;Computers;Cues;Data;Decision Making;Electrophysiology (science);Environment;Environmental Wind;experimental study;Exposure to;Food;Genetic;Goals;Head;Image;Implant;insight;interest;Label;Liquid substance;Measures;Mental disorders;miniaturize;Modeling;Monitor;Mus;Nature;neural;neural circuit;neuroimaging;neurophysiology;Neurosciences;Nose;Nutrient;Odors;olfactory bulb;Olfactory Pathways;Organism;Outcome;Output;Parkinson Disease;Partner in relationship;Pathologic;Performance;Phase;Polar Bear;Positioning Attribute;predictive modeling;Process;Resources;Schizophrenia;seal;sensor;Sensory;sensory input;sensory integration;Series;simulation;Soil;Source;Structure;Techniques;Testing;tool;Training;transmission process;Travel;Viral;Virus

PROJECT_TITLE: Navigation with complex odor dynamics: computational principles and neural circuit implementation in mice

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: UW NATHAN SHOCK CENTER OVERALL - PROJECT NARRATIVE We apply for renewal of the Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington, which has for 25 years provided key resources supporting investigators who study the biology of aging. The overarching goal of this Center is to have a positive impact on the field by accelerating research discovery and providing research support for investigators nationally and internationally, particularly junior investigators in the process of building their own research programs. We will accomplish this goal through six cores that function synergistically together: four Resource Cores with particular expertise in protein (Core C) and metabolite (Core D) phenotypes of aging, invertebrate longevity and healthspan phenotypes (Core E) and artificial intelligence and bioinformatics (Core F), along with a Research Development Core (Core B) that supports external pilot projects and junior faculty studies, and an Administrative and Program Enrichment Core (Core A) that supports administrative management, an external advisory panel, sponsorship and organization of national meetings and pre-meetings, courses, workshops and seminars, and, in coordination with other Nathan Shock Centers, a Geropathology Research initiative.

PI_NAMEs: MARCINEK, DAVID J. (contact);YOUNG, JESSICA ELAINE

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Acceleration;Aging;aging related;Ally;Artificial Intelligence;Bioinformatics;bioinformatics tool;Biological Assay;Biology of Aging;career development;cell age;Collaborations;Communication;Communities;computerized tools;Data;Data Analyses;data dissemination;data sharing;Development;Educational workshop;Environment;Experimental Designs;Faculty;Genes;Genetic study;Gerontology;Geropathology;Geroscience;Goals;Growth;healthspan;high dimensionality;Informatics;insight;Institution;International;Invertebrates;Leadership;Longevity;meetings;metabolomics;Methodology;Methods;Microfluidics;Molecular;multiple omics;novel;Office of Administrative Management;outreach;outreach services;Pathway interactions;Phenotype;Philosophy;Pilot Projects;Post-Translational Protein Processing;Process;programs;Proteins;Proteomics;Research;Research Activity;research and development;Research Personnel;Research Support;Resources;Robotics;Services;Shock;Statistical Data Interpretation;symposium;Technology;tool;trait;Transcript;Universities;Variant;Washington

PROJECT_TITLE: Nathan Shock Center of Excellence in Basic Biology of Aging


NIH_SPENDING_CATS: Aging

PI_NAMEs: YOUNG, JESSICA ELAINE (contact)

PROJECT_TERMS: Advertising;Aging;Award;Biology of Aging;career;career development;Data;Faculty;Funding;Grant;Individual;member;Mentors;Mentorship;Monitor;Performance;Pilot Projects;Play;Positioning Attribute;programs;Reagent;research and development;Research Personnel;Resources;Role;senior faculty;Services;Shock;Time

PROJECT_TITLE: Core B: Research Development


PI_NAMEs: RABINOVITCH, PETER S (contact)

PROJECT_TITLE: Core A: Program Enrichment/Administrative


PI_NAMEs: MACCOSS, MICHAEL  (contact)

PROJECT_TITLE: Core C: Protein Phenotypes of Aging