NIH_SPENDING_CATS: Clinical Research;Neurosciences

ORG_CITY: RICHARDSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE Primary muscle tension dysphonia (pMTD) is a functional voice disorder that negatively affects communication, occupation, and quality of life. Although excessive paralaryngeal muscle activity and altered phonatory breathing patterns are thought to underlie symptoms of vocal effort, fatigue, and discomfort in pMTD, there is conflicting evidence for the role of paralaryngeal-respiratory movement patterns in these clinical presentations due to lack of robust methodological tools to study these relationships. We use novel application of motion capture technology to study these movement patterns in patients with and without pMTD and their relationship to pMTD symptomology.

PI_NAMEs: SHEMBEL, ADRIANNA  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TITLE: Paralaryngeal-Respiratory Spatiotemporal Patterns in Muscle Tension Dysphonia


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke

ORG_CITY: CHARLOTTESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative: Stroke has one of the most striking health disparities in the United States with African Americans at substantially greater risk of having a stroke, having a recurrent stroke, and dying from a stroke. Epigenetics can provide a lens through which to view how the environment, including social and structural determinants of health, and an individual’s unique genetic code interact to influence disease risk and outcomes. The goal of this proposal is to generate epigenetic data and leverage existing genomic and phenotypic data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study to identify unique and shared determinants of stroke risk and recurrence stroke risk to allow improved personalization of risk assessment and targeted prevention of recurrent strokes, while reducing the stroke disparities using a multiethnic population.

PI_NAMEs: HSU, FANG-CHI ;KEENE, KEITH L;WORRALL, BRADFORD B (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: accelerated epigenetic aging;Address;Adult;Affect;African American population;African ancestry;American;Behavioral;Biological Markers;Biology;built environment;Cause of Death;Clinical;clinical risk;cohort;Communities;comorbidity;Data;Data Set;disability;Disease Outcome;disorder risk;Disparity;DNA Methylation;Economic Factors;Economics;Education;Environment;Environmental Risk Factor;Epigenetic Process;epigenome;epigenome-wide association studies;Ethnic Population;Etiology;European;European ancestry;Event;Genetic;genetic association;Genetic Code;Genetic Determinism;genetic makeup;Genetic Markers;Genetic Risk;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic data;genomic locus;Genotype;Goals;hazard;Health;health care availability;health disparity;health equity;high risk;Hypermethylation;Hypertension;improved;Individual;innovation;intergenerational;Knowledge;Lead;lens;Linear Regressions;Lipids;Lived experience;Logistic Regressions;Long term disability;Measures;Mediating;Mediation;Meta-Analysis;Methods;Methylation;Modeling;multi-ethnic;Multiomic Data;National Institute of Neurological Disorders and Stroke;National Institute on Minority Health and Health Disparities;Nature;Neighborhoods;novel;novel marker;Outcome;Participant;Pathway Analysis;Persons;Phenotype;phenotypic data;polygenic risk score;Predisposition;prevention clinical trial;Quality Control;Reasons for Geographic And Racial Differences in Stroke;Recurrence;recurrence prevention;Recurrence Score;Research;Risk;Risk Assessment;Risk Factors;Role;Site;SNP genotyping;social;social determinants;social factors;social health determinants;sociocultural determinant;Stroke;stroke intervention;Stroke prevention;stroke risk;structural health determinants;Survivors;Techniques;Testing;Time;tool;trait;United States;Vitamins;Work

PROJECT_TITLE: Shared and novel contributors to risk of stroke and stroke recurrence in a multiethnic population – the role of social determinants of health, genetics, and epigenetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-T (02)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE This research will implement and characterize genetic crosses to identify key molecular determinants associated with artemisinin resistance and reduced lumefantrine susceptibility in African Plasmodium falciparum malaria parasites and characterize the impact of these mutations on parasite fitness and transmission. The results will provide robust molecular markers that can be used for molecular surveillance of parasites resistant to this first- line drug in Africa, where the disease burden is by far the greatest in the world. Our findings will help guide strategies to protect artemisinin-based combination therapies, impede the spread and establishment of multidrug resistance, and inform strategies to design more effective antimalarial drug treatments aimed at reducing malaria’s massive impact on global health.

PI_NAMEs: MOK, SACHEL  (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Affect;Africa;African;Alcohols;Alleles;Anopheles Genus;Anti-malarials;artemether;Artemisinins;asexual;benflumetol;Biological Assay;biomarker identification;Blood;burden of illness;Candidate Disease Gene;candidate identification;candidate marker;candidate validation;Cessation of life;Chromosome Mapping;clinical efficacy;clinically relevant;Combined Modality Therapy;Compensation;Complex;Complex Genetic Trait;cost;Country;Coupled;CRISPR/Cas technology;Culicidae;Data;Defect;design;Discrimination;drug efficacy;Drug resistance;drug-sensitive;Ethiopia;experience;Face;Falciparum Malaria;fitness;frontier;Gene Frequency;Genes;Genetic;genetic architecture;Genetic Crosses;genome sequencing;genomic locus;genomic profiles;global health;Growth;Head;humanized mouse;In Vitro;in vivo;Inbred NOD Mice;insight;Link;Malaria;Maps;Measures;Mediating;Mediator;Mefloquine;Molecular;molecular marker;mouse model;Multi-Drug Resistance;mutant;Mutation;novel marker;Oocysts;Parasite resistance;Parasites;Parents;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Plasmodium falciparum;Polygenic Traits;Positioning Attribute;Predisposition;pressure;Prevalence;Proliferating;Quantitative Trait Loci;Recombinants;Reporting;Research;Resistance;resistant strain;response;reverse genetics;Role;Rwanda;Sampling;Signal Transduction;southeast Asian;Sporozoites;Technology;Testing;tool;transmission process;Treatment Efficacy;Uganda;Validation;vector;vector mosquito;whole genome

PROJECT_TITLE: The genetic basis of emerging multidrug resistance in Plasmodium falciparum African malaria

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project narrative Preeclampsia is a hypertensive pregnancy disorder that increases risk of morbidity and mortality to both mother and baby. The disease symptoms resolve following delivery of placenta, which is the current only definitive treatment, but it can lead to medically necessitated preterm deliveries. Understanding the detailed mechanisms of preeclampsia will allow us to establish better disease interventions, treatments, and preventions, which will improve both mom and the baby’s overall long-term health.

PI_NAMEs: HORII, MARIKO  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Abnormal Cell;Acceleration;Affect;arteriole;Biological Assay;Biological Models;Blood Vessels;Cell Differentiation process;Cell Proliferation;Cells;Characteristics;Chorionic villi;Chromatin;Clinical;Complex;cytokine;cytotrophoblast;Data;Defect;diagnostic biomarker;Disease;DNA;early onset;Enhancers;epigenetic memory;Epigenetic Process;fetal;Fetal Growth Retardation;fetal loss;Functional disorder;Gene Expression;Goals;Health;Histologic;Human;Hypertension;hypertensive;Immunophenotyping;improved;in vitro Model;Incidence;induced pluripotent stem cell;Infarction;Injury;Intervention;Invaded;Lesion;Medical;Mesenchymal;Methods;methylome;Modeling;Molecular;molecular phenotype;Morbidity - disease rate;mortality;Mothers;novel;Organ;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Pattern;Phenotype;Placenta;Pre-Eclampsia;Pregnancy;pregnancy disorder;Premature Birth;Prenatal care;preservation;Prevention;Proliferating;Proteinuria;Risk;Sampling;stem;stem cell model;stem cell proliferation;stem cells;Stromal Cells;Symptoms;Syncytiotrophoblast;Syndrome;Testing;therapeutic target;tool;transcriptome;transcriptomics;trophoblast;trophoblast stem cell;Umbilical cord structure;Villous;Woman;Work

PROJECT_TITLE: Stem Cell-based Modeling of Placental Defects associated with Early-Onset Preeclampsia

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Unlike normal cells, majority of cancer cells and nearly all of small cell lung cancers activate an enzyme called telomerase to replicate end of the chromosomes to bypass replicative senescence. Telomerase is essential for the survival of these cancer cells. We are proposing that targeting telomerase can sensitize small cell lung cancer to existing therapies.

PI_NAMEs: AKBAY, ESRA  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Activated Natural Killer Cell;adaptive immunity;analog;anti-PD-1/PD-L1;anti-PD-L1 antibodies;anti-tumor immune response;antigen-specific T cells;antitumor effect;Apoptosis;Bypass;cancer cell;cancer initiation;cancer survival;Cell Aging;Cell Count;Cell Cycle Arrest;Cell Cycle Checkpoint;Cell division;Cell Line;Cell Survival;Cells;chemoradiation;Chemoresistance;chemotherapy;Chemotherapy and/or radiation;Chest;Chromosomes;Cisplatin;Clinical Trials Design;comparative efficacy;cytotoxic;Data;Deoxyguanosine;Dependence;Development;Disease;Dissociation;DNA;DNA biosynthesis;DNA Damage;DNA Repair;Dose;effective therapy;efficacy evaluation;Enzymes;Etoposide;exceptional responders;Extensive Stage;Goals;Growth;Guanine;Holoenzymes;Human;Human Cell Line;humanized mouse;Immune;immune checkpoint blockade;Immune Evasion;Immune response;Immune system;Immunocompetent;Immunocompromised Host;immunogenicity;Immunologics;Immunotherapy;improved;In Vitro;in vitro Model;Incidence;Individual;Infiltration;inhibitor;innovation;Interferon Type I;Interferons;Ligands;Limited Stage;Lung;Lymphocytic Infiltrate;Malignant Neoplasms;Mediating;micronucleus;Mitosis;Mitotic;Modeling;Mouse Cell Line;mouse model;Mus;Natural Immunity;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;Neural Cell Adhesion Molecule L1;neuroendocrine cancer;Non-Malignant;Non-Small-Cell Lung Carcinoma;Normal Cell;novel;novel therapeutics;Oncogene Activation;Pathway interactions;patient derived xenograft model;Patients;Poly(ADP-ribose) Polymerase Inhibitor;premature;prevent;Primary Neoplasm;Production;Prognosis;Proteins;Radiation;Radiation therapy;rational design;Recommendation;Regimen;Relapse;replication stress;Research Priority;Resistance;response;side effect;Signal Transduction;small cell lung carcinoma;small molecule;Solid Neoplasm;standard of care;synergism;T cell response;T-Lymphocyte;Telomerase;telomere;Telomere Shortening;temozolomide;Testing;Therapeutic;therapeutically effective;Tissues;Toxic effect;Treatment Efficacy;treatment response;tumor;Tumor Immunity;Work

PROJECT_TITLE: Overcoming Therapy Resistance in SCLC

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative We have created a novel platform to test drug sensitivity of human cancers using fresh core needle biopsies. It takes into consideration of the tumor microenvironment and provides early readouts of response. Before taking this assay into the clinic, we aim to define the optimal pre- analytical conditions that will allow for reproducible and reliable test performance, including the impact of the type and size of the biopsy needles, tissue handling and storage, culture conditions and dissociation protocols. We will further test our standard operating procedure (SOP) in a pilot study of liver cancers to demonstrate clinical feasibility in preparation for a clinical trial.

PI_NAMEs: WEI, WEI ;YEUNG, RAYMOND  (contact)

PROGRAM_OFFICER_NAME: RAO, ABHI

PROJECT_TERMS: Address;Affect;American Society of Clinical Oncology;Architecture;assay development;base;biobank;Biological Assay;Biometry;Biopsy;Cancer Center;cancer clinical trial;Cancer Model;Cell Count;Cells;Cellular Assay;Characteristics;Clinic;clinic ready;Clinical;Clinical Research;Clinical Trials;cohort;Collaborations;Colorectal;Community Clinical Oncology Program;companion diagnostics;Core Biopsy;cost;Culture Media;Data;design;detection assay;Development;Dissociation;Drug Exposure;drug sensitivity;drug testing;Enrollment;Ensure;Environment;FDA approved;Foundations;Friends;Future;Goals;Human;improved;Individual;ineffective therapies;Institution;Institutional Review Boards;interest;Intrahepatic Cholangiocarcinoma;Liver neoplasms;Malignant neoplasm of liver;Malignant Neoplasms;Measures;member;Metabolic;Metastatic Neoplasm to the Liver;Mus;Needle biopsy procedure;neglect;neoplastic cell;next generation;novel;Oncologist;Organoids;Patients;Performance;performance tests;Pharmaceutical Preparations;Pilot Projects;Practice Guidelines;precision drugs;precision oncology;Preparation;preservation;Procedures;Proliferating;prospective;Protocols documentation;Recording of previous events;Recovery;Regimen;Reliability of Results;Reproducibility;Reproducibility of Results;Research;Resistance;Resort;response;sample collection;Science;Solid;Solid Neoplasm;sound;success;Systems Biology;Testing;Therapeutic;Time;Time Factors;Tissue Banks;Tissue Viability;Tissues;Toxic effect;transcriptome;Transportation;treatment duration;Treatment Factor;tumor;tumor heterogeneity;tumor metabolism;tumor microenvironment;Tumor Pathology;Tumor Tissue;Universities;Validation;validation studies;Washington

PROJECT_TITLE: MetaboCore: Needle biopsy assay of drug sensitivity for solid tumors.

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-D (J1)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_CITY: RICHMOND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE Periodontitis is one of the most common diseases in humans and is caused by increased bacterial accumulation that leads to severe inflammation. This study aims to characterize the systems Treponema denticola, a key periodontal pathogen, uses to sense and respond to environmental stimuli. Understanding the mechanisms that promote T. denticola adaptation and survival is critical to developing novel therapeutics or approaches to prevent periodontitis.

PI_NAMEs: MILLER, DANIEL PATRICK (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Adult;Aerobic;Affect;Affinity;Alveolar Bone Loss;Bacteria;Binding;Binding Sites;biological adaptation to stress;Cell Physiology;Cell Wall;Chemotaxis;ChIP-seq;chronic inflammatory disease;Communities;Community Developments;Complex;Cytoplasm;Data;Development;Disease;DNA Binding;DNA-Directed RNA Polymerase;Dominant-Negative Mutation;enhancer binding protein;Enhancers;Environment;fitness;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;Genomics;Gingiva;Glycine;Growth;Health;Heme;Homologous Gene;Human;Immune response;Inflammation;inflammatory marker;insight;Kinetics;Knock-out;Knowledge;Literature;Mediating;Metabolism;microbial;Microbial Biofilms;microbial community;Molecular;Motility;mouse model;mutant;novel strategies;novel therapeutics;oral bacteria;Organism;overexpression;Oxidation-Reduction;Oxygen;pathobiont;Pathogenicity;Periodontal Diseases;Periodontitis;Periodontium;periodontopathogen;Phosphorylation;Phosphotransferases;Physiology;Population;Porphyromonas gingivalis;prevent;promoter;Promoter Regions;protein-histidine kinase;Proteins;Publishing;Quantitative Reverse Transcriptase PCR;Regulation;Regulon;response;Role;sensor;Sensory;Severities;Sigma Factor;Signal Transduction;Site;Stimulus;stoichiometry;Surface Plasmon Resonance;System;Testing;transcription factor;transcriptome sequencing;Treatment Cost;Treponema denticola;Virulence

PROJECT_TITLE: Two-component signaling systems of Treponema denticola

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative: This research proposal aims to develop robust and precise 600µm whole-brain qMRI and dMRI techniques for studying infant brain development. By improving image resolution and fidelity, we can better understand microstructural changes in infant brain. The proposed advancements in MRI technology will provide valuable insights into early brain development.

PI_NAMEs: LIAO, CONGYU  (contact)

PROGRAM_OFFICER_NAME: MACHLIN, LAURA STONER

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;aged;Algorithms;Anisotropy;axon growth;Biological Markers;Biophysics;Brain;Brain region;Clinical;Clinical Research;Consumption;contrast imaging;Data;data acquisition;density;design;Development;Diffusion;Diffusion Magnetic Resonance Imaging;early childhood;experience;extrastriate visual cortex;falls;Fiber;Fingerprint;Grant;gray matter;Head;Home;Image;Imaging technology;improved;in vivo;infancy;Infant;innovative technologies;insight;Investigation;Magnetic Resonance Imaging;Maps;Measurement;Measures;Modeling;Motion;motion sensitivity;MRI Scans;Myelin;myelination;Noise;physical model;Play;postnatal;Process;Proliferating;Property;Protocols documentation;Protons;reconstruction;Recovery;Relaxation;Research Proposals;research study;Resolution;Role;Scanning;Signal Transduction;spatiotemporal;spectroscopic imaging;structural imaging;Structure;Techniques;Technology;technology development;Time;Tissues;Translating;Translations;Validation;Variant;Visual Cortex;Visualization;Water;white matter

PROJECT_TITLE: Robust and precise imaging of infant brain development with magnetic resonance imaging

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Social Determinants of Health

PHR: Concerns about deteriorating mental health, substance use disorders, early development of chronic conditions, exposure to economic shocks, and to violence---causes that may all lead to premature mortality among adolescents and young adults in the United States, have been rising in recent public discourse. The magnitude and root causes for these developments are poorly understood. In this project we will construct new large-scale datasets on mortality and socio- economic circumstances of adolescents and young adults in the United States, measure how mortality evolved over time and space, and analyze the contribution of social determinants to observed mortality patterns.

PI_NAMEs: POLYAKOVA, MARIA  (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Adolescent;Adolescent and Young Adult;Age;age group;American;Birth;Birth Records;Censuses;Cessation of life;Characteristics;Chronic;Collaborations;Communities;Community Surveys;Data;Data Aggregation;Data Linkages;Data Set;Databases;Death Rate;Death Records;demographics;Deterioration;Development;Diagnosis;Disability status;Distal;Divorce;Drops;Drug Prescriptions;Drug Utilization;econometrics;Economics;Education;Ethnic Origin;Exposure to;Family;Future;Geographic Locations;Geography;Health;health care availability;health care service utilization;health data;Health Personnel;Healthcare;Healthcare Systems;improved;Income;Individual;Inequality;Infant;Infrastructure;large scale data;Lead;Link;Measures;Medicaid;Mental Health;Methods;mortality;Mortality Determinants;Natural experiment;Nature;Occupations;older adult;Outcome;Pathway interactions;Pattern;Personal Satisfaction;Persons;Play;Population;Premature Mortality;Prevalence;programs;Provider;public health insurance;Race;Records;Regression Analysis;Research;Research Personnel;Role;Running;Series;sex;Shapes;Shock;social;social determinants;social health determinants;Societies;socioeconomics;Source;stem;Substance Use Disorder;Taxes;Techniques;Time;trend;United States;Variant;Violence;young adult;Youth

PROJECT_TITLE: Social Determinants of Adolescent and Young Adult Mortality: New Evidence from Large-Scale Administrative Data

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative This project will involve a rigorous randomized control trial to examine the effects of integrating evidence-based practices for attention and reading within a single, unified intervention called Supporting Attention and Reading for Kids (SPARK) for students with co-occurring reading and attention difficulties in Grades 3 - 5. Despite decades of research on reading disabilities, the efficacy of existing interventions for improving reading in upper elementary students (Grades 3 – 5) remains limited and is relatively understudied relative to studies with children in the early elementary grades. The results of this study will have immediate and extensive impact on research and clinical practice (e.g., enhancing the approaches to remediating reading difficulties) for an understudied population, students with co-occurring reading and attention difficulties.

PI_NAMEs: CAPIN, PHIL J (contact);ROBERTS, GARRETT J

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;arm;Attention;behavior measurement;behavior observation;Behavioral;behavioral outcome;Child;Clinical;clinical practice;contextual factors;design;Education;Effectiveness;efficacy evaluation;Evidence based practice;experience;follow-up;Growth;Health;improved;inattention;innovation;Instruction;Intervention;intervention effect;Learning;Link;Mediating;Mediator;Outcome;Participant;Performance;Personal Satisfaction;Pilot Projects;Population;post intervention;processing speed;Public Health;Randomized, Controlled Trials;Reading;reading comprehension;reading difficulties;Reading Disabilities;remediation;Research;Research Personnel;response;Schools;Severities;Short-Term Memory;Students;sustained attention;Testing;therapy design;Time;Vocabulary

PROJECT_TITLE: Integrating Reading and Attention Practices to Maximize Learning for Students with Co-Occurring Difficulties

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Heart Disease;Liver Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE In order to improve the success rate of clinical trials by reducing the dependence on animal testing, we are developing miniature models of human organs on a chip. By using custom robots to place cells in specific starting positions, we have been able to guide them to create a tube-shaped miniature heart that might be more accurate than other sphere shaped miniature hearts. We aim to thoroughly test this new human heart model, and combine it with a similarly generated liver model in order to study interactions between the heart and liver in normal and diseased scenarios.

PI_NAMEs: SACHS, DAVID  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Ammonium;Animal Model;Animal Testing;Architecture;Behavior;Biological Models;Biomimetics;Blood Vessels;Cardiac;Cardiovascular Diseases;cardiovascular effects;Cardiovascular Models;Cardiovascular Physiology;Cardiovascular system;Cell Survival;Cells;chronic liver disease;Clinical Trials;Custom;Data;Dependence;design;Development;Disease;Drug Modulation;endothelial dysfunction;enzyme activity;Exposure to;Failure;Functional disorder;Gene Expression;Geometry;Glycogen;Goals;Growth;Heart;Heart Hypertrophy;Heart Rate;Hepatic;Hepatocyte;Human;human model;improved;In Situ;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Infrastructure;Left Ventricular Hypertrophy;Liver;Liver diseases;Low-Density Lipoproteins;Metabolism;Microfluidic Microchips;Microfluidics;microphysiology system;Modeling;morphogens;mortality;non-alcoholic fatty liver disease;novel therapeutics;Organ;organ on a chip;Organoids;Paracrine Communication;Pathology;Perfusion;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Positioning Attribute;Prevalence;Probability;Protein Secretion;Proteomics;Pump;response;Robot;Robotics;self assembly;Shapes;single-cell RNA sequencing;Source;spheroids;stem cell model;Structure;success;System;Testing;Therapeutic;therapeutic development;Time;Toxic effect;Tube;Tubular formation;uptake;Validation

PROJECT_TITLE: Microfluidic organoid model of cardio-hepatic physiology and disease

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative In the proposed experiments, we will use a novel UCS deflation approach to weaken fear behavior; here, presentations of a weaker version of an unconditional stimulus can produce persistent reductions in fear responding. We will combine behavioral, circuit, cellular, and molecular approaches to gain a detailed understanding of the mechanisms through which weak shock exposure functions to reduce fear behavior and circumvent behavioral responding common to extinction learning. The results from these studies will be immediately applicable to human behavioral treatments aiming to address fear and anxiety behavior long-term.

PI_NAMEs: TRASK, SYDNEY  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TITLE: Behavioral, circuit, and molecular mechanisms underlying UCS deflation

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Fibroid Tumors (Uterine);Women's Health Research

ORG_CITY: Nashville

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative: Public Health Relevance Four in every five women will have uterine fibroids in their lifetime, over 1.6 million will be diagnosed each year, and over half a million of those will undergo surgery for fibroids. Two-thirds of these women will have invasive surgery to remove their uterus, even though the best surgeons have shown that just over 50,000 of them per year could have minimally invasive uterine-sparing endoscopic interventions if they were fortunate enough to be treated by an elite surgeon. We propose to create a new robot that makes endoscopic fibroid removal easier to perform, so that many more surgeons can offer it to many more women every year.

PI_NAMEs: WEBSTER, ROBERT JAMES (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TITLE: A New Robot to Replace Hysterectomies with Minimally Invasive Uterine-Sparing Interventions

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative This research project aims to utilize quantitative susceptibility mapping (QSM) to establish a clinically feasible, accurate, and robust treatment biomarker for chronic inflammation in multiple sclerosis (MS). Our primary objectives include investigating the effectiveness of current treatments in reducing inflammation in chronic MS lesions and examining their impact on clinical disability. The successful outcome of this research will provide clinicians with a valuable tool to assign therapeutic regimens more accurately.

PI_NAMEs: GAUTHIER, SUSAN A (contact);NGUYEN, THANH D

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Acceleration;Acute;adaptive immune response;Adoption;axon injury;B-Lymphocytes;Biological Markers;Biophysics;Blood - brain barrier anatomy;blood-brain barrier disruption;Cells;Chronic;Clinical;clinically relevant;Cognitive;cohort;Consensus;conventional therapy;Data;Demyelinations;Detection;detection sensitivity;Development;disability;Disease;Disease Progression;Effectiveness;Exhibits;Fumarates;Goals;Image;Immune;improved;in vivo;in vivo monitoring;Individual;Infiltration;Inflammation;Inflammatory;Injury;innovation;Iron;Learning;Lesion;Magnetic Resonance Imaging;Maps;Measures;Methods;millimeter;Modeling;Monitor;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;multiple sclerosis treatment;Myelin;neural network;novel;novel strategies;Outcome;Outcomes Research;Pathogenesis;Pathologic;Patient Care;Patients;Pattern;Physics;Positron-Emission Tomography;Predisposition;prevent;promoter;Prospective Studies;Proteins;Reader;reconstruction;Regimen;Reproducibility;Research Project Grants;Resolution;response;Sampling;Scanning;Slice;Source;Subgroup;targeted treatment;Technology;Testing;Therapeutic;Thick;Time;tool;treatment optimization;treatment response;treatment strategy;Validation;Visualization;Work

PROJECT_TITLE: Quantification of the Innate Immune Activity within Chronic Lesions as a Novel Treatment Biomarker in Multiple Sclerosis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cancer;Colorectal Cancer;Coronaviruses;Coronaviruses Therapeutics and Interventions;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Narrative The administration in vivo of fusion proteins composed of an anti-immunoglobulin light chain nanobody, VHHkappa, and a nanobody that recognizes virus-infected cells or tumor cells results in the recruitment to the targeted cell of polyclonal immunoglobulins of all isotypes and of indeterminate specificity. In vivo administration of such fusions eliminates these targeted cells, including tumors. We will define in detail the underlying mechanisms of action and include cytotoxic drugs to further improve the efficacy of such fusions.

PI_NAMEs: WU, HAO  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 2019-nCoV;adduct;Agonist;Animals;Anti-Bacterial Agents;anti-CTLA4;anti-fungal agents;Anti-Infective Agents;anti-PD-L1;anti-tumor agent;antibody-dependent cell cytotoxicity;Area;Binding;Biodistribution;Biological Assay;Bone Marrow Purging;Boston;Cancerous;CD8B1 gene;Cells;Chimeric Proteins;Clinical;clinical translation;Colon Carcinoma;Complement-Dependent Cytotoxicity;CTLA4 gene;Cytotoxic agent;Data;Disabling;Dose;Ebola;Ebola virus;experimental study;Failure;Fc Immunoglobulins;Generations;Genetic;Genetic Complementation Test;Glycoproteins;Half-Life;HIV;HIV Envelope Protein gp120;Human;IgG1;IgG2;IgG3;IgG4;immune modulating agents;immune stimulatory agent;Immunity;Immunoglobulin A;Immunoglobulins;improved;In Vitro;in vivo;in vivo Model;Influenza;influenza infection;Influenza Virus Infected Cells;influenza virus strain;influenzavirus;Injections;kappa-Chain Immunoglobulins;Knockout Mice;Lead;Lethal Dose 50;Light;Light-Chain Immunoglobulins;MC38;Mediating;medical schools;Melanoma;MHC Class II Genes;Modeling;Molecular;Monoclonal Antibodies;Mus;mutant;Mutation;nanobodies;neoplastic cell;Neuraminidase;Neuraminidase inhibitor;novel;overexpression;pathogen;Phagocytosis;Pharmaceutical Preparations;preclinical study;programmed cell death ligand 1;Prophylactic treatment;Publishing;Reaction;receptor binding;recruit;Research Personnel;response;SARS-CoV-2 spike protein;Series;small molecule;sortase;Specificity;success;Surface;Testing;therapeutically effective;TLR7 gene;Transgenic Mice;translational approach;tumor;tumor microenvironment;Universities;Viral;Viral Proteins;Virus;Virus Diseases;Washington;Work;zanamivir

PROJECT_TITLE: Armed nanobodies as anti-infectives and anti-tumor agents

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Retinal ganglion cell degeneration underlies vision loss in traumatic injuries and optic neuropathies like glaucoma. Strategies to promote retinal ganglion cell neuroprotection and axon regeneration remain an unrealized clinical goal. This project will deeply explore cell-type specific activity-related mechanisms mediating retinal ganglion cell survival and growth after axonal injury.

PI_NAMEs: TRAN, NICHOLAS MINH ABELL (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Adult;Affect;Amacrine Cells;Animal Model;axon injury;axon regeneration;Blindness;cell growth;Cell Physiology;cell regeneration;Cell Survival;cell type;Cells;cellular resilience;Clinical;Complement;Corticotropin-Releasing Hormone;Cyclic AMP;Dendrites;Development;Disease;Evaluation;experimental study;Functional Imaging;Gene Expression;Genetic Transcription;Glaucoma;Goals;Growth;hormonal signals;Hormone Responsive;Immediate-Early Genes;improved;In Vitro;in vivo;injured;Injury;insight;interdisciplinary approach;Intervention;mature animal;Mediating;Membrane Potentials;Modeling;Molecular;Molecular Target;Morphology;Mus;Natural regeneration;Nerve Crush;Nerve Degeneration;neural circuit;Neurites;neuronal excitability;neuronal survival;Neurons;Neuropeptides;neuroprotection;neuroregulation;Optic Nerve;optic nerve disorder;Optic Nerve Injuries;overexpression;patch clamp;Pathway interactions;Physiological;Physiology;Population;postnatal;pre-clinical;Predisposition;preservation;presynaptic;Primary Cell Cultures;Process;programs;Property;Recovery;regenerative;resilience;response;response to injury;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinal regeneration;Role;screening;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Testing;Therapeutic;transcriptomics;Traumatic injury;treatment effect;urocortin;Visual;Work

PROJECT_TITLE: Activity-related mechanisms of selective retinal ganglion cell resilience and axon regeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Physical Activity

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Relevance: We hypothesize that changes in the biochemical/metabolic state of the heart in heart failure impair the mechanical pumping ability of the heart. Testing and refining of this hypothesis will lead to a deeper understanding of why and how the function of the heart changes in heart failure and will point to new potential avenues for treatment. Our proposal investigates this hypothesized mechanical-energetic link by using multi-scale computer models to analyze data from human subjects.

PI_NAMEs: BEARD, DANIEL A (contact)

PROGRAM_OFFICER_NAME: SHANBHAG, SUJATA MADHUKAR

PROJECT_TERMS: Accounting;Age;aged;Anatomy;Animal Model;Artificial Heart;ATP Hydrolysis;autonomic reflex;Baroreflex;Biochemical;Blood Vessels;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;Cardiac Output;Cardiopulmonary;cardiorespiratory fitness;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;clinical phenotype;cohort;Computer Models;Coupling;Data;Data Set;EFRAC;Energy Metabolism;Energy Supply;Equilibrium;Exercise;exercise capacity;exercise intolerance;Exercise Test;Failure;Force of Gravity;Free Energy;Functional disorder;Goals;healthy aging;Heart;Heart failure;heart function;hemodynamics;Human;human data;human model;human subject;Hydrolysis;Image;impaired capacity;Impairment;in vivo;Individual;inorganic phosphate;Intrinsic factor;Left;Leg;Link;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Mechanics;Mediating;Metabolic;Metabolic dysfunction;Metabolism;Modeling;Monitor;mortality;multi-scale modeling;Muscle;Myocardial;Myocardium;Output;Oxygen;Patients;Performance;Peripheral;Phenotype;Physiological;Physiology;Posture;Power Sources;preservation;Pump;Quality of life;recruit;Relaxation;Research;response;Rest;sex;simulation;Stress;study population;System;Systems Analysis;Testing;vasoconstriction;Vasodilation;Venous Pressure level;Ventricular;Work

PROJECT_TITLE: Multi-Scale Systems Analysis of Metabolic and Mechanical Determinants of Reserve Cardiac Power Output

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE  The proposed work will fill a major gap of our knowledge in understanding function of FMRP in primate brain development. Such understanding is critical for better therapeutic development for fragile X syndrome as well as other neurodevelopmental disorders including autism.

PI_NAMEs: ZHAO, XINYU  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adult;Affect;Age;autism spectrum disorder;Behavioral;Binding Proteins;Brain;Cells;Clinical Trials;Complex;Creativeness;crosslinking and immunoprecipitation sequencing;Data;Decision Making;Development;Electrophysiology (science);Essential Genes;Exhibits;fetal;Fragile X Syndrome;Gene Expression;Genes;genetic signature;Goals;Heritability;Human;human pluripotent stem cell;Impairment;Intellectual functioning disability;Intelligence;knock-down;Knowledge;Language;Link;Macaca;Macaca mulatta;Mass Spectrum Analysis;Mediating;messenger ribonucleoprotein;Messenger RNA;Metabolic;Methods;Mitochondria;Modeling;Molecular;Morphology;Mus;Mutation;Neurodevelopmental Disorder;Neuronal Differentiation;Neurons;patch clamp;patch sequencing;Pathogenesis;Physiological;pluripotent stem cell differentiation;postnatal;postnatal development;Prefrontal Cortex;prenatal;primary endpoint;Primates;Protein Deficiency;protein function;Proteins;Publications;Regulation;Resolution;RNA-Binding Proteins;Rodent;Rodent Model;Role;Sampling;Short-Term Memory;Slice;synaptogenesis;Testing;therapeutic development;tissue resource;transcriptomics;Work

PROJECT_TITLE: Interrogate FMRP functions in primate brain development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Pediatric

ORG_CITY: AMHERST

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT DESCRIPTION Deoxyribonucleotide triphosphates (dNTPs) are the building blocks of DNA and sufficient quantities are required to copy the genome before cells divide. Our proposal aims to understand how elevated dNTP pools compromise genome stability and cellular fitness.

PI_NAMEs: SURTEES, JENNIFER ANNE (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;Alleles;Binding;Binding Sites;Bioinformatics;Biological Sciences;Biomedical Research;cancer cell;Catalytic Domain;Cell Cycle;Cell Cycle Checkpoint;Cell division;Cell Physiology;Cell Survival;Cells;college;Communities;Community Health Education;Complex;Data;deep sequencing;Defect;Deoxyribonucleotides;Development;Disparity;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA metabolism;DNA replication fork;DNA-Directed DNA Polymerase;Ecosystem;educational atmosphere;elementary school;Ensure;Eukaryota;Event;Evolution;Exonuclease;experience;Exposure to;fitness;gene repair;Genes;Genetic;genetic approach;Genome;Genome Stability;Genomic approach;high school;Homologous Gene;human disease;Inherited;junior high school;K-12 student;Laboratories;Lead;Malignant Neoplasms;Mismatch Repair;Molecular Conformation;Molecular Evolution;Mutagenesis;Mutation;Neurodegenerative Disorders;novel;Nucleotides;Okazaki fragments;Pathway interactions;Polymerase;Process;programs;Proliferating;recruit;repaired;Replication Error;Replication Origin;replication stress;Research;Research Personnel;response;Ribonucleotide Reductase;Ribonucleotide Reductase Subunit;RNR1 gene;Role;Saccharomyces cerevisiae;Science;Source;Specificity;spelling;student mentoring;student participation;Students;Substrate Specificity;Supporting Cell;System;Time;tripolyphosphate;undergraduate student;Underrepresented Populations;Universities

PROJECT_TITLE: Characterizing the role of Elevated dNTP pools in sensitizing the replisome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (56)]


NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE One of the key features of asthma is exaggerated airway narrowing by hypercontractile airway smooth muscle. Our group has shown that smooth muscle cells narrow the airway by transmitting force through tethering proteins. The goals of this project are to determine the pathways by which pro-inflammatory signals activate these tethering proteins and to study a specific tethering protein that binds smooth muscle cells to one another, with the hope of identifying new therapeutic targets for the treatment of chronic airways disease.

PI_NAMEs: SUNDARAM, APARNA BALA (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Actins;Adhesions;Adrenergic beta-Agonists;Antibodies;Area;Asthma;asthma model;asthmatic;asthmatic patient;Binding;Binding Proteins;Biology;Biopsy;cadherin-11;Cadherins;Cell membrane;Cells;Cessation of life;chronic respiratory disease;Complex;Contracts;cytokine;Data;Development;Disease;Extracellular Matrix;Family;Goals;Grant;Homeostasis;IL17 gene;Imaging Device;imaging modality;Inflammatory;innovation;insight;Integrin alpha5beta1;Integrins;Interleukin-13;Investigational Therapies;Knowledge;Laboratories;Ligation;Link;Mediating;Mediator;methacholine;Microfilaments;Molecular Conformation;Mus;Muscle;Muscle Contraction;Myosin ATPase;Myosin Light Chain Kinase;Myosin Phosphatase Pathway;new therapeutic target;novel;novel therapeutics;Outcome;Pathway interactions;Peptides;Phosphatidylinositol 4,5-Diphosphate;Physiological;Play;Proteins;Research;respiratory smooth muscle;response;Rho-associated kinase;Role;Sampling;Signal Pathway;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Stimulus;Talin;targeted treatment;Testing;Time;Tissues;tool;Toxic effect;Transgenic Organisms;translational impact;transmission process;two photon microscopy;Visualization;Work

PROJECT_TITLE: Mechanisms of Cytokine-Mediated Integrin Activation and Force Transmission in Airway Smooth Muscle

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alcoholism, Alcohol Use and Health;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Conditions Affecting the Embryonic and Fetal Periods;Dementia;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ALBUQUERQUE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE A distressingly high number of children in the United States, approximately 2-5%, live with fetal alcohol spectrum disorders, the result of damage to the developing fetus from prenatal alcohol exposure (PAE). Because there are currently no known treatments that can reverse PAE-mediated damage, it is essential that we understand its molecular underpinnings and investigate novel avenues of research such as those defining the role of vascular defects in the developing brain during PAE. This study will uncover novel molecular mechanisms that drive abnormal vascular development in the brain during PAE and reveal potential therapeutic targets for FASD patients.

PI_NAMEs: GARDINER, AMY S (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Adherens Junction;adverse outcome;Affect;Alcohol consumption;alcohol exposure;angiogenesis;Animals;Area;Arteries;Attention;Automobile Driving;Behavioral;Binding;Blood - brain barrier anatomy;Blood Vessels;Brain;brain endothelial cell;Brain Pathology;Cardiac;Cell Separation;Cells;Central Nervous System;Cerebral cortex;Cerebral endothelium;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;Characteristics;Child;comparison control;Cortical vasculature;curative treatments;Data;Defect;Development;Diameter;differential expression;digital;disability;Distress;Embryo;embryonic alcohol exposure;Embryonic Development;Endothelial Cells;Endothelium;Enzymes;Exhibits;experience;Face;fetal;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Development;Fluorescence Microscopy;Functional disorder;Gene Expression;gene function;Genetic;Genetic Transcription;Goals;Growth;Heterozygote;improved;in vivo;Incidence;Individual;insight;Ischemia;Knock-out;Life;Literature;Matrix Metalloproteinases;Mediating;Methylation;MicroRNAs;Microscopy;Modeling;Molecular;Molecular Target;Morphogenesis;Morphology;mouse model;mRNA Expression;Mus;neurobehavioral;Neurocognitive;neuron development;Neurons;neurovascular unit;novel;overexpression;Pathology;Pathway interactions;Patients;Permeability;Physiological;Population;Positioning Attribute;Post-Transcriptional Regulation;postnatal;posttranscriptional;Pregnancy;preservation;promoter;Property;Proteins;Proteome;Reporting;Research;response;RNA;Role;Structure;System;Techniques;Testing;Therapeutic Intervention;therapeutic target;Tight Junctions;Tissues;Tracer;transcription factor;Transcriptional Regulation;transcriptome;United States;vascular abnormality;Vascular Diseases;Work

PROJECT_TITLE: Molecular Targeting of the Cerebrovasculature During Prenatal Alcohol Exposure

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Burden of Illness;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Complementary and Integrative Health;Depression;Digestive Diseases;Disability Research;Mental Health;Orphan Drug;Palliative Care;Rare Diseases;Rehabilitation;Sleep Research;Telehealth

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Project Narrative The proposed research is consistent with public health goals to reduce patient symptom interference with functioning and family caregiver burden in advanced cancer. Acceptance and commitment therapy (ACT) is a novel approach to addressing these public health issues that showed promise in our pilot study with patient- caregiver dyads coping with advanced gastrointestinal cancer. This phase II randomized trial will examine the effect of telephone-delivered ACT on patient fatigue interference and caregiver burden in this population and, following positive trial findings, ACT may be readily integrated into comprehensive clinical care.

PI_NAMEs: MOSHER, CATHERINE E (contact)

PROGRAM_OFFICER_NAME: RICHMOND, ELLEN S

PROJECT_TERMS: Acceptance Process;Address;Adoption;Adult;Advanced Malignant Neoplasm;Affect;American;Anxiety;anxiety symptoms;Attention;Awareness;behavior change;Behavior Therapy;cancer care;Cancer Family;Cancer Intervention;Cancer Patient;cancer type;care giving burden;Caregiver Burden;Caregivers;caregiving;clinical care;Cognition;Cognitive;Cognitive Therapy;colon cancer patients;Colorectal;coping;depressive symptoms;Diagnosis;disability;disabling symptom;Disease;Distant;Distress;Education;efficacy evaluation;Eligibility Determination;Esophagus;evidence base;Evidence based intervention;Exercise;experience;Face;Family;Family Caregiver;Fatigue;Feeling;flexibility;follow-up;Foundations;Functional impairment;functional outcomes;Funding;gastrointestinal symptom;Geography;Goals;health goals;Impairment;improved;Individual;Intervention;Liver;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of ovary;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Mediator;Meditation;men;Mental Depression;Meta-Analysis;metastatic colorectal;mindfulness;Moods;neglect;novel;novel strategies;Outcome;Pancreas;Patient-Focused Outcomes;Patients;pharmacologic;Phase;phase II trial;Pilot Projects;pilot trial;Population;post intervention;primary outcome;Process;psychologic;Public Health;Quality of life;Randomized;randomized trial;reduce symptoms;Reporting;Research;Sampling;secondary outcome;Self Care;Sleep;Sleep Disorders;Source;Subgroup;Symptom Burden;Symptoms;Telephone;telephone based;telephone delivery;telephone session;Testing;Therapeutic Intervention;Thinking;Time;Translations;Treatment Efficacy;Woman;Work

PROJECT_TITLE: Acceptance and Commitment Therapy for Patient Fatigue Interference and Caregiver Burden in Advanced Gastrointestinal Cancer

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Preeclampsia is a serious pregnancy complication with limited diagnostic and treatment options. Our project aims to investigate the role of the vaginal ecosystem - its microbes, metabolites, and the host’s immune system - in preeclampsia, using samples from a large and deeply phenotyped cohort of pregnant women - the nuMoM2b study. Our study will identify new biomarkers for preeclampsia and highlight potential mechanisms underlying it, ultimately paving the way for new diagnostics and therapeutic targets that will improve maternal and neonatal health outcomes.

PI_NAMEs: KOREM, TAL  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: adverse pregnancy outcome;Antigens;Biological Markers;biomarker discovery;biomarker identification;Characteristics;Clinical;Clinical Data;cohort;Communities;Complex;Computational Biology;Data;Data Set;data-driven model;Development;Diagnosis;Diagnostic;early pregnancy;Ecosystem;Epidemiology;First Pregnancy Trimester;Future;Genes;Genetic;Geography;Goals;Growth;gut microbiome;Heterogeneity;host microbiome;Hypertension;Immune;Immune system;Immunity;Immunoassay;immunogenic;Immunologic Factors;Impairment;improved;Infection;Inflammation;Inflammatory;insight;Investigation;Kidney;Liver;machine learning prediction;Maternal Health;Maternal-fetal medicine;Mediating;Mediator;Metabolic Pathway;metabolome;metabolomics;metagenome;metagenomic sequencing;Metagenomics;Microbe;microbial;Microbiology;microbiome;microorganism interaction;Modeling;Molecular;multiple omics;Neonatal;neonatal health;new therapeutic target;novel;novel diagnostics;Nulliparity;oral microbiome;Organ;Outcome;Phenotype;Placenta;Placentation;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnant Women;Premature Birth;Prevention;Process;Property;Race;reproductive organ;Research Personnel;Resolution;Resources;Risk Marker;risk prediction model;Role;Sampling;Second Pregnancy Trimester;Site;Source;Spiral Artery of the Endometrium;supervised learning;Swab;Therapeutic;therapeutic target;Time;Training;Vagina;vaginal microbiome;Validation;Variant;Woman

PROJECT_TITLE: A large scale investigation of the vaginal ecosystem in preeclampsia

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Health Relevance Narrative: Loss of mitochondrial function can be debilitating in the nervous system, as evident from its association with numerous neurological diseases and disorders – including forms of Parkinson’s Disease, Leigh Syndrome, or other movement disorders. In order to develop more effective treatments for mitopathies of the nervous system, we need better understanding of the cellular and synaptic consequences of mitochondrial dysfunction. This proposal addresses that problem, using a genetic model of Mitochondrial Complex I dysfunction.

PI_NAMEs: FRANK, CARL ANDREW (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Address;Affect;Apoptosis;Ataxia;Axonal Transport;Buffers;Calcium;Cell Physiology;Cell Survival;Cells;Chemosensitization;Collection;Complex;Curiosities;Cytology;Data;Defect;density;Depressed mood;Disease;Drosophila genus;Drosophila melanogaster;effective therapy;Electrophysiology (science);Energy-Generating Resources;Epilepsy;Failure;Functional disorder;Genetic;Genetic Diseases;Genetic Models;Genetic Screening;Glycolysis;Goals;Health;Homeostasis;Image;Impairment;Individual;Intuition;Investigation;Knowledge;Leigh Disease;loss of function;Mediating;Mitochondria;mitochondrial dysfunction;Modality;Modeling;Motor Neurons;Movement;Movement Disorders;Muscle;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurologic;Neuromuscular conditions;Neuromuscular Junction;neuronal survival;Neurons;neurotransmission;neurotransmitter release;Outcome;Output;Oxidative Phosphorylation;Parkinson Disease;Pathway interactions;Pharmacology;Phenotype;Physiological;postsynaptic;presynaptic;presynaptic neurons;Process;Production;protein complex;Proteins;Reaction;Reactive Oxygen Species;Research;Research Design;response;Role;Scientist;Signal Transduction;Sorting;Source;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;System;Testing;Tissues;Work

PROJECT_TITLE: Synaptic defects caused by mitochondrial complex I dysfunction

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Radiation Oncology;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative We propose to explore the mechanisms underlying poly(ADP-ribose)-signaling in IDH mutant gliomas to develop modalities that selectively target these tumors. Our application is relevant to public health because IDH mutant gliomas are common in younger adults, and universally evade the current aggressive therapies and remain lethal, necessitating the identification of novel therapeutic approaches. Relevant to the NCI mission, the objective of this study is to understand sensitivities to specific signaling pathway perturbation, to inform strategies that can improve the efficacy of novel targeted and existing therapies.

PI_NAMEs: CAHILL, DANIEL P. (contact);WAKIMOTO, HIROAKI

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Acceleration;Adult;Aftercare;aggressive therapy;Alkylating Agents;Automobile Driving;biological adaptation to stress;BRCA1 gene;cancer cell;Caspase;Cell Death;Cell Death Signaling Process;Cells;Clinic;Clinical;clinical development;clinical translation;combinatorial;Combined Modality Therapy;Consumption;cytotoxicity;Dependence;Diffuse;DNA analysis;DNA biosynthesis;DNA Damage;DNA replication fork;DNA-dependent protein kinase;DNA-PKcs;Dose;efficacy evaluation;Enzymes;Etiology;Genes;Genetic;genotoxicity;Glioma;Glycoside Hydrolases;Goals;Hematology;homologous recombination deficiency;improved;in vitro Model;in vivo;inhibitor;innovation;Investigation;Ionizing radiation;Isocitrate Dehydrogenase;Knowledge;Laboratories;Link;Malignant Glioma;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metabolism;Mission;Modality;Modeling;Molecular;mutant;Mutation;Natural History;neoplastic cell;Nicotinamide adenine dinucleotide;Normal Cell;novel;novel therapeutic intervention;Pathway interactions;Patients;pharmacologic;Phenotype;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Polymerase;Polymers;Pre-Clinical Model;Predisposition;Public Health;Radiation;radiation effect;Radiation therapy;recruit;replication stress;Research;response;Role;Signal Pathway;Signal Transduction;standard care;Supplementation;systemic toxicity;temozolomide;Testing;Therapeutic;Therapeutic Effect;Toxic effect;Translations;tumor;Work;XRCC1 gene;young adult

PROJECT_TITLE: Analyzing DNA replication and damage vulnerability in IDH mutant glioma

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Hearing Loss;Infectious Diseases;Machine Learning and Artificial Intelligence;Neurosciences;Otitis Media;Pediatric

ORG_CITY: AUSTIN

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE  Otitis media is the second most common reason children go to the doctor. This project will provide evidence of long-lasting functional listening deficits in children resulting from otitis media after the pathology has resolved. This will have a significant theoretical and translational impact on the early identification and intervention of pediatric hearing loss resulting from otitis media.

PI_NAMEs: MISHRA, SRIKANTA  (contact);PATRO, CHHAYAKANTA

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: 3-Dimensional;Affect;Animal Model;Attention;Attenuated;Audiology;Auditory;auditory deprivation;auditory processing;Binaural;Child;Childhood;childhood hearing loss;Clinical;Cognition;Cognitive;Communication;comparison control;Conductive hearing loss;critical period;Cross-Sectional Studies;Cues;Data;data-driven model;demographics;deprivation;design;Detection;Development;Disease;early childhood;Early identification;Early Intervention;Emotions;Environment;Evaluation;experience;experimental study;explainable machine learning;Frequencies;global health;Goals;Hearing;hearing impairment;Human;Impairment;improved;Individual;Individual Differences;innovation;Knowledge;Laboratories;Language;Language Development;Learning;Link;literacy;Machine Learning;machine learning model;Measures;Mediating;middle ear;Modeling;Music;Neuronal Plasticity;Neurosciences;Noise;Otitis Media;Otolaryngology;Outcome;Pathology;Pediatrics;Perception;Performance;precision medicine;Psychometrics;Recording of previous events;research clinical testing;Residual state;Resolution;response;Risk;risk prediction;segregation;Sensory;Sensory Deprivation;skills;sound;Speech;speech in noise;speech recognition;Speech-Language Pathology;Testing;tool;training data;translational impact;Tube;Tympanostomy;Validation;Work

PROJECT_TITLE: Functional Consequences of Early Childhood Otitis Media

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Head and Spine Injury

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE More than 1.3 million new patients are diagnosed each year with conditions that may result in elevated intra- cranial pressure (ICP). In these patients, the limited ability to make accurate, stable pressure measurements with wireless, MRI compatible devices contributes to poor clinical outcomes. It is hypothesized that a novel ul- trasound-based wireless transduction approach combined with an implanted pressure sensitive target has the potential to accurately diagnose shunt failure, improving patient management while reducing cost.

PI_NAMEs: LINDSEY, BROOKS D;MYERS, DAVID RICHARD (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Abbreviations;Acceleration;accurate diagnosis;Acoustics;Acute;Air;Air Movements;Animals;automated analysis;Brain;Chronic;Clinical;Communities;cost;cranium;Data;Development;Devices;Diagnosis;Diffuse;electric impedance;experience;Failure;Feedback;Fiber Optics;Glossary;Human Resources;Image;imaging study;Implant;Implantation procedure;implanted sensor;improved;in vitro testing;in vivo;innovation;Intracranial Hypertension;Intracranial Pressure;Intraventricular;Liquid substance;Magnetic Resonance Imaging;Measurement;Measures;Medical;Membrane;microsensor;microsystems;Monitor;Neurologic;Neurosurgeon;neurosurgery;novel;novel strategies;operation;Outcome;Outpatients;packaging material;Patient Monitoring;Patients;Performance;performance tests;Physiologic intraventricular pressure;porcine model;pressure;pressure sensor;Pressure Transducers;prototype;radio frequency;research clinical testing;response;Risk;Scanning;seal;sensor;Shunt Device;sound;Speed;Stress;System;Technology;Telemetry;Testing;Thinness;Time;tool;Translations;Traumatic Brain Injury;Trephine hole;Tube;ultrasound;Vacuum;Visualization;water vapor;wireless

PROJECT_TITLE: iPPSIS: implanted Passive Pressure Sensor Interrogated with (ultra)-Sound

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Data Science;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PUBLIC HEALTH RELEVANCE Small-Molecule Penetration and Efflux in Gram-Negative Bacteria Infections by Gram-negative bacteria pose a growing threat to public health in the U.S. and globally, due to the intrinsic resistance of these pathogens to many antibiotics. A major obstacle to the development of new antibiotics to combat these infections is our poor understanding of the structural requirements for small- molecule drugs to penetrate the Gram-negative cell envelope barrier and to avoid expulsion by efflux pumps. This multidisciplinary project will address this problem by using a comprehensive experimental and computational platform to analyze, model, and predict small-molecule penetration and efflux in three Gram- negative pathogens, thus enabling the development of new Gram-negative antibiotics.

PI_NAMEs: DUERFELDT, ADAM SCOTT;RYBENKOV, VALENTIN V;TAN, DEREK S (contact);ZGURSKAYA, HELEN I

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;Address;Algorithms;analog;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Area;Bacteria;Bacterial Infections;Biochemical;Biochemistry;Biological Assay;cell envelope;Cell membrane;Cells;chemical synthesis;Chemicals;cheminformatics;combat;Communities;Complex;computational platform;Computer Models;Data;design;Development;drug discovery;Drug Targeting;Effectiveness;efflux pump;Escherichia coli;Evaluation;Experimental Models;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;high throughput screening;improved;Incidence;Individual;Infection;inhibitor;large datasets;Lead;lead optimization;Libraries;Machine Learning;machine learning model;Maps;Mass Spectrum Analysis;Membrane;Membrane Proteins;method development;Microbiology;Minnesota;model building;Modeling;multidisciplinary;mutant;novel;Oklahoma;Organism;pathogen;Pathway interactions;Penetrance;Penetration;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Positioning Attribute;predictive modeling;Property;Pseudomonas aeruginosa;Public Health;public health relevance;Reagent;Resistance;Role;scaffold;screening;small molecule;small molecule libraries;Specificity;success;Synthesis Chemistry;Technology;Training;uptake;Validation;VDAC1 gene

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Diabetes;Digestive Diseases;Lung;Orphan Drug;Pediatric;Prevention;Rare Diseases;Regenerative Medicine

PHR: Project Narrative Highly effective modulator therapy (HEMT) has recently become available for the majority of people with cystic fibrosis (CF). The effects on lung function can be quite dramatic but the effects on the pancreas are minimal, probably due to the fact that the pancreas undergoes fibrosis which is complete by the teen years. In this study, we aim to uncover novel insights into the biological mechanisms driving the natural history of disease progression in CF by revealing how the newest HEMT, Trikafta™, improves pulmonary and pancreatic function in young children, an age with great potential for growth and repair.

PI_NAMEs: KAMALESWARAN, RISHIKESAN ;STECENKO, ARLENE A (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: 5 year old;Adult;Age;age group;aged;Airway Disease;Automobile Driving;Biological;Biological Assay;blood glucose regulation;Bronchiectasis;chest computed tomography;Child;Chronic;Clinical;cohort;Complication;Computational algorithm;Continuous Glucose Monitor;Cystic Fibrosis;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Data;data integration;Delta F508 mutation;disease natural history;Disease Progression;Elastases;Endocrine;Event;Exhalation;Exocrine pancreas;Exocrine pancreatic insufficiency;FDA approved;Fibrocystic Disease of Pancreas;Fibrosis;Gases;Glucose;Glucose Intolerance;glucose metabolism;glucose tolerance;Growth;Hyperglycemia;improved;indexing;infancy;insight;insulin secretion;insulin sensitivity;Islets of Langerhans;Lung;Lung Diseases;lung health;Machine Learning;Measurement;Measures;Mediating;metabolomics;Mucous body substance;multimodality;Mutation;Natural regeneration;novel;novel therapeutics;OGTT;open label;organ growth;organ repair;Organ Size;Pancreas;Pancreatic Diseases;Pathologic;Persons;Phenotype;Physical condensation;Prediabetes syndrome;prevent;Prevention;Probability;Proteins;pulmonary function;Pulmonary function tests;pulmonary symptom;Records;repaired;Resolution;response;restoration;Source;Spirometry;standard of care;Structure;Techniques;Teenagers;Testing;Therapeutic;Tissues;VX-770;Weaning;X-Ray Computed Tomography

PROJECT_TITLE: Pulmonary and pancreatic response to cystic fibrosis modulator therapy in young children


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Agroforestry is an age-old agricultural practice that intertwines crops, livestock and forest, serving as an important strategy for climate change mitigation that is being implemented globally. In this study, our aim is to examine how agroforestry, compared to other farming practices, influences the risk of zoonotic mosquito-borne viral infections in humans and livestock in Darien, Panama. Our ultimate goal is to generate insights that will guide public health and agricultural policies, thereby ensuring alignment of climate and health objectives within the context of agroforestry.

PI_NAMEs: VITTOR, AMY YOMIKO (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acute;Address;Adoption;Affect;Agriculture;Agrochemicals;Alpha Virus;Animals;anthropogenesis;arboviral disease;Arbovirus Infections;Arboviruses;Arthropod Vectors;arthropod-borne;Benefits and Risks;Biodiversity;Blood;Breeding;burden of illness;Characteristics;chikungunya;Climate;climate change;climate impact;climate-related health;Clinical;Collaborations;Communicable Diseases;Communities;Complex;Culicidae;Data;Deforestation;Disease;Disease Outbreaks;disease transmission;disorder risk;Ecology;Economics;Ensure;Entomology;Environment;enzootic;Epidemiology;epidemiology study;epizootic;Evolution;Farm;Fever;forest;Fostering;Future;Genes;Genetic;Genome;Geography;Goals;Habitats;Health;health assessment;health determinants;health goals;Health Policy;Household;Human;human old age (65+);Incidence;Individual;infection rate;insight;Intervention;Interview;Irrigation;Knowledge;land conversion;land cover;Land Tenure;land use;Livestock;Maps;Measures;Mediating;Methodology;Methods;Microclimate;Modeling;mosquito-borne;Natural Selections;Orthobunyavirus;Outcomes Research;Ownership;Panama;Participant;Planet Earth;Policies;Population;Population Dynamics;preference;pressure;Preventive measure;Province;Public Health;Research;Risk;Role;Rural Population;Scheme;seroconversion;serosurvey;Shapes;skills;social determinants;Solid;Specimen;Surveys;System;Testing;Time;transmission process;trend;Trinidad;Variant;vector;Vector Ecology;Venezuelan Equine Encephalitis Virus;Vertebrates;Viral;Viral Genes;viral genomics;viral transmission;Virus;Virus Diseases;virus genetics;Water;water quality;West Nile;Work;ZIKA;Zoonoses

PROJECT_TITLE: Aligning climate and health: assessing zoonotic arboviral risks in agroforestry as a climate mitigation strategy

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: ARLINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: PROJECT NARRATIVE: Aging is the primary risk factor for cardiovascular disease, this in large part due to aging of the arteries. Emerging evidence suggests that CD8+ T cells accumulate around the arteries with age and drive tissue inflammation and dysfunction in these tissues. The results from this proposal will determine how CD8+ T cell aging results in inflammation and dysfunction of the arteries.

PI_NAMEs: TROTT, DANIEL  (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Address;Adoptive Transfer;Adult;Age;age related;aged;Aging;aging process;antagonist;Antibodies;Aorta;arterial stiffness;Arteries;Atherosclerosis;Automobile Driving;Biological Availability;Biomechanics;Blood Vessels;brachial artery;Cardiovascular Diseases;cardiovascular risk factor;CCR5 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Aging;Cell Communication;Cell Count;Cell Culture Techniques;cell type;Cells;chemokine;Clinical;Coculture Techniques;Collagen;cytokine;Data;Deposition;Development;Elderly;Endothelial Cells;endothelial dysfunction;Endothelium;Exhibits;experimental study;Fibroblasts;Fibrosis;Flow Cytometry;Functional disorder;Genetic;Health;Histology;Human;Immune;Immune system;Immunology;Impairment;in vivo;Inflammation;Inflammatory;insight;Intervention;Knock-out;Lead;Mechanics;Mediating;Memory;Mesenteric Arteries;Mesentery;Methods;Modeling;Molecular;mouse model;Mus;next generation sequencing;Nitric Oxide;novel;old mice;older adult;Outcome Assessment;pharmacologic;Phenotype;Physiologic pulse;Physiology;Plasma;Play;preservation;Production;Proteins;RANTES;receptor;recruit;risk prediction;Rodent Model;Role;Series;Signal Transduction;single-cell RNA sequencing;Smooth Muscle;Stroke;T cell therapy;T-Lymphocyte;Techniques;Testing;Tissues;trafficking;transcription factor;transcriptomics;translational potential;translational study;Wild Type Mouse

PROJECT_TITLE: Mechanisms of CD8+ mediated cell non-autonomous arterial aging

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Rare Diseases;Stomach Cancer

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE This proposal will seek to develop a novel microfluidic “tumor-on-a-chip” platform for studying peritoneal carcinomatosis – a diffuse spreading pattern of metastasis of the peritoneal cavity and the most lethal form of metastasis of colon and gastric cancer. Colon and gastric cancer are the third and fifth most prevalent cancers worldwide, respectively, and most people who die from the disease do so because of metastases, such as those to the peritoneal cavity. This platform will provide a new tool to help researchers understand this process, and ultimately identify drugs that will effectively treat and prevent this process from happening.

PI_NAMEs: HUGHES, CHRISTOPHER C. W. (contact);SENTHIL, MAHESWARI

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: 3-Dimensional;anti-cancer research;Biomimetics;Blood Vessels;Cancer Etiology;Carcinomatosis;cell behavior;Cell Proliferation;Cells;Cessation of life;Clinical Research;Collaborations;colon cancer metastasis;Colon Carcinoma;Colorectal Cancer;Complex;Data;Dental Cavity Lining;Development;Diffuse;Disease;Disease remission;Distant;Dose;Drug Combinations;drug repurposing;drug sensitivity;drug testing;Environment;ethnic disparity;Funding Opportunities;Goals;Greater sac of peritoneum;Growth;Hand;Hyperthermia;hyperthermia treatment;Image;improved;In Vitro;in vitro Model;in vivo;Incidence;intraperitoneal;Knowledge;Malignant Neoplasms;malignant stomach neoplasm;Mesothelial Cell;Mesothelium;Metabolism;Microfluidics;Micrometastasis;microphysiology system;migration;Modeling;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Organ;Patients;Pattern;PECAM1 gene;Performance;Perfusion;Peritoneal;Peritoneum;Persons;Pharmaceutical Preparations;Physicians;prevent;Primary Neoplasm;Process;prospective;Publishing;Recurrent disease;Research;Research Personnel;response;Sampling;single-cell RNA sequencing;standard of care;success;Surface;Surgical Oncologist;Survival Rate;Systemic Therapy;Technology;Testing;therapeutic development;Tissue Engineering;Tissues;tool;tool development;tumor;Tumor Debulking;vascular bed;Vascularization

PROJECT_TITLE: A vascularized microphysiological system (MPS) platform for modeling peritoneal carcinomatosis

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Hookworm infection is a leading cause of anemia and malnutrition in poor countries, especially sub-Saharan Africa. We will produce the first reference genome for an African strain of Necator americanus hookworms and develop genomic tools to monitor deworming drugs' effect on Ghana's parasite populations. The studies proposed here will add significantly to our understanding of hookworm genomics and provide a bioinformatic foundation for the future development of improved diagnostics, drugs, and vaccines for human infection.

PI_NAMEs: CAPPELLO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Acceleration;Address;Africa;Africa South of the Sahara;African;Albendazole;Anemia;Animal Model;Anthelmintics;Area;benzimidazole;Bioinformatics;Child;China;Chromosomes;Collaborations;Communities;community transmission;companion animal;Country;Cross-Sectional Studies;Data;data streams;Development;Diagnostic;disability-adjusted life years;Disease;drug efficacy;Drug Exposure;Drug resistance;Effectiveness;egg;Epidemiologic Factors;Epidemiology;epidemiology study;field study;Foundations;Future;Gene Expression;Genes;Genetic;Genome;genome resource;genome sequencing;genome wide association study;Genomic approach;genomic data;genomic tools;Genomics;Geography;Ghana;Goals;Hamsters;Helminths;Hookworm Infections;Hookworms;Human;improved;In Vitro;Individual;Infection;Integration Host Factors;Intervention;Knowledge;Laboratories;Laboratory Study;Livestock;low and middle-income countries;Malnutrition;Mediating;Methodology;Modeling;Monitor;multidisciplinary;Municipalities;Necator americanus;neglected tropical diseases;novel;Parasites;Persons;Pharmaceutical Preparations;Phenotype;Play;Population;Population Heterogeneity;Predisposition;preservation;Prevalence;programs;Public Health;reference genome;Reporting;Research;Research Personnel;Resistance;response;Risk;Role;scale up;Soil;Structure;success;Surveys;targeted treatment;Testing;Time;transmission process;Treatment Effectiveness;treatment response;Universities;Vaccines;Variant;whole genome;Width;women's morbidity;World Health Organization;years of life lost

PROJECT_TITLE: Genomic approaches to define hookworm population diversity and deworming drug response

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE This project will identify structural aspects of the health care system that reduce or increase disparities in mental health care by race, ethnicity and disability status. To do so, we will develop a database of provider opening, closing, consolidation, and ownership changes related to mental health care and provide a summary of variations in the provider landscape for mental health care for disadvantaged groups. Our causal analyses will reveal targets for policy interventions to improve the mental health of disadvantaged populations and reduce the disparate impacts of public policies.

PI_NAMEs: MAESTAS, NICOLE A (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: access disparities;Adult;Affect;Age;Area;Beds;Blue Cross;Blue Shield;Caring;collaborative care;Communities;cost;COVID-19 pandemic;Data;Data Set;Databases;Diagnosis;disability;Disability status;Disabled Persons;Disadvantaged;Disease;Disease remission;Disparity;Disparity population;disparity reduction;Distress;distrust;effective therapy;Equity;ethnic disparity;ethnic minority population;Ethnic Origin;experience;Face;Functional impairment;health assessment;health care cost/financing;health care service;health care service utilization;health disparity;Health Personnel;Health Services Accessibility;Healthcare Systems;Hispanic Populations;Improve Access;improved;Income;Individual;Individuals with physical disabilities;Inequity;Inpatients;Insurance;Insurance Carriers;insurance claims;Insurance Coverage;Intervention;Investments;Knowledge;Life Cycle Stages;Location;Marketing;Measures;Medicaid;Medicare;Medicare/Medicaid;Mental disorders;Mental Health;mental health organization;Mental Health Services;Minority Groups;Modeling;Morbidity - disease rate;novel;outcome disparities;Outpatients;Ownership;Patients;Pattern;physically handicapped;Policies;prevent;primary care provider;Privatization;Provider;Psyche structure;Public Policy;Quality of Care;Quasi-experiment;Race;racial disparity;racial minority;racial minority population;Research Design;Role;Service provision;Shapes;social stigma;structural determinants;Structure;Symptoms;telehealth;Training;Variant

PROJECT_TITLE: Mental Health Care for Disadvantaged Populations: The Role of the Provider Landscape

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: NARRATIVE Use of amphetamine and its congeners is currently higher than ever before, surpassing that of all other illicit substances. Substance use disorder, particularly to psychostimulants like amphetamine, is a serious problem in today’s society, compounded by lack of effective therapeutics to treat psychostimulant addiction. This proposal examines the potential of targeting a molecular mechanism, phosphorylation/regulation of the norepinephrine transporter, to reduce the rewarding effects of amphetamine and drug-seeking behavior.

PI_NAMEs: DAWS, LYNETTE C;JAYANTHI, LANKUPALLE D (contact);RAMAMOORTHY, SAMMANDA

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: addiction;Adult;amphetamine use;Amphetamines;Animal Behavior;Attenuated;Behavior;behavior measurement;Behavioral;behavioral response;behavioral study;Biochemical;Brain region;Complex;COVID-19 pandemic;Cre lox recombination system;design;Disease;Dopamine-beta-monooxygenase;drug seeking behavior;Exhibits;extracellular;Female;Functional disorder;Genotype;Goals;In Vitro;in vivo;Infusion procedures;insight;Interruption;Investigation;Knock-in Mouse;Knowledge;Lead;Link;male;Measures;Medial;Mediating;Mediator;Microdialysis;Modeling;Molecular;Mus;mutant;mutant mouse model;Mutant Strains Mice;Neurobiology;neurochemistry;Neurons;neurotransmission;noradrenaline transporter;noradrenergic;Norepinephrine;novel;Nucleus Accumbens;Outcome;Peptides;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Play;Post-Translational Protein Processing;Prefrontal Cortex;Process;Protein Dynamics;Protein Kinase C;protein protein interaction;Proteins;psychostimulant;Publishing;Regulation;response;Rewards;Role;sex;Sex Differences;Signal Transduction;Societies;Speed;Stimulant;stimulant dependence;stimulant use;Substance Use Disorder;TACR1 gene;Techniques;Testing;Therapeutic Intervention;therapeutically effective;trafficking;uptake;Variant;Viral;Viral Vector

PROJECT_TITLE: The role of norepinephrine transporter phosphorylation in amphetamine reward

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN DIEGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative Latino children generally have lower participation in leisure-time physical activity and unhealthy dietary habits and higher rates of overweight and obesity. Effective intervention programs are needed which target improvements in physical activity (PA) and cardiovascular fitness (CVF) rather than focus on weight loss. This study will test the effects of a 12-month community-based, family-centered behavioral intervention to influence improvements in PA and CVF outcomes among underserved Latino families in the U.S.-Mexico border region, while gathering information on program implementation and sustainability.

PI_NAMEs: CRESPO, NOE CUAUHTEMOC (contact);GONZALEZ, DANIELA GUADALUPE

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: acceptability and feasibility;Acculturation;Address;arm;Back;Behavior;behavior change;Behavior Therapy;Behavioral;bilingualism;Body Image;Body Weight decreased;Border Community;California;cardiometabolic risk;cardiovascular fitness;cardiovascular risk factor;Caregivers;Child;Child Health;Child Rearing;Chronic Disease;Cities;Classification;Communities;community academic partnership;community center;community collaboration;Community Health Aides;Control Groups;Diet Habits;Disease;disorder risk;Dissemination and Implementation;effective intervention;effectiveness/implementation study;efficacy testing;Enrollment;Environment;Ethnic Population;exercise intervention;Exhibits;experience;experimental group;Exposure to;Family;fitness;Goals;group intervention;Health;Health behavior;Health Benefit;Heart Diseases;high risk population;Hybrids;implementation facilitators;implementation intervention;implementation outcomes;improve minority health;improved;Individual;information gathering;Intervention;intervention program;Knowledge;Latino;Latino Population;Leisures;Life;Life Style;Low income;Measures;Mediator;Methods;Mexico;Modeling;National Institute on Minority Health and Health Disparities;novel;Obesity;obesity prevention;obesogenic;Outcome;Overweight;Parents;Pattern;Performance;Phase;Physical activity;Physical environment;Physical Fitness;Pilot Projects;Play;Population;preventive intervention;primary outcome;Process;process evaluation;Program Acceptability;programs;Public Policy;Randomized;Recreation;Reduce health disparities;Research;Research Design;Research Personnel;Resources;Risk Factors;Role;Series;Shapes;social culture;Students;success;Testing;theories;Time;timeline;Training;Travel;underserved community;Weight

PROJECT_TITLE: Promoting Physical Activity and Fitness Among Underserved Latino Families Living in U.S.-Mexico Border Regions

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetic Testing;Genetics;Human Genome;Infant Mortality;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: PACIFIC NORTHWEST RESEARCH INSTITUTE

PHR: Project Narrative Urea cycle disorders are serious, but treatable, inherited diseases caused by DNA sequence variants that impair the function of any of eight different proteins in human liver cells. Although timely diagnosis and treatment is key to improving patient outcomes, the lack of sufficiently reliable biochemical tests for several of these diseases has prevented them from being included in newborn screening panels. This project will develop tools to assess a newborn’s genetic risk of developing a severe urea cycle disorder.

PI_NAMEs: DUDLEY, AIMEE M (contact);GROPMAN, ANDREA LYNNE

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;Alleles;Amino Acid Substitution;Ammonia;Benign;Biochemical;Biochemical Pathway;Biological;Biological Assay;Birth;Blood;Brain;Cerebral Edema;Cessation of life;Classification;Clinical;Clinical Data;Code;Collaborations;Coma;Computer Models;Data;Data Set;design;Detection;Development;Diagnosis;Diagnostic;Disease;disease phenotype;Disease stratification;DNA Sequence;Early identification;Enzymes;Genes;Genetic;genetic predictors;Genetic Risk;Genome;genome sequencing;genotyped patients;Hepatocyte;Hereditary Disease;Heterozygote;Human;Impairment;improved;Individual;Infant;Infant Care;Inherited;Literature;Longitudinal Studies;Measurement;Measures;Morbidity - disease rate;mortality;Neonatal;Neonatal Screening;neurotoxic;Newborn Infant;Outcome;Pathogenicity;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Persons;Phenotype;Population;predictive tools;prevent;Prognosis;protein function;Proteins;Rare Diseases;rare variant;Reporting;Resources;screening panel;Severity of illness;Specificity;Testing;tool;Urea;urea cycle;Urea cycle disorders;Validation;Variant;variant of unknown significance

PROJECT_TITLE: Development and application of variant interpretation platforms to advance detection of urea cycle disorders by newborn genome sequencing

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: A significant proportion of patients may experience poor outcomes (either refractory or recurrent disease) within 6 weeks after standard antibiotic treatment for bacterial vaginosis (BV). Finding baseline vaginal micro- environmental factors associated with these early adverse outcomes could produce candidate biomarkers for these conditions, and ultimately change clinical practice by identifying patients who may require more aggressive initial therapies. Here, we propose to recruit a cohort of patients initiating therapy for acute BV and follow them over 6 weeks to identify vaginal microenvironmental factors associated with refractory or early recurrent BV resultant specimen repository may also be leveraged for future studies to reveal underlying mechanisms (and ultimately improved treatments) for these conditions.

PI_NAMEs: TUDDENHAM, SUSAN ANNE (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Acute;adverse outcome;aged;Anaerobic Bacteria;Antibiotic Therapy;Antibiotics;Atopobium vaginae;Automobile Driving;Bacteria;Bacterial Vaginosis;Behavioral;Biological;Biological Response Modifier Therapy;Biological Specimen Banks;Boric Acids;candidate identification;candidate marker;Caring;Cell Death;cell injury;cis-female;Clindamycin;Clinical;clinical biomarkers;clinical candidate;clinical practice;cohort;CXCL9 gene;cytotoxic;Data;Detection;Development;Diagnosis;Disease;Disease remission;Dose;Drug resistance;early experience;Enrollment;Epithelial Cells;experience;Functional disorder;Future;Gardnerella;Gardnerella vaginalis;Glycogen;Grant;Growth;HIV;HIV/STD;Immune response;Immune System Diseases;Immunologics;improved;Individual;insight;Interleukin-1 beta;Interleukin-4;Intervention Studies;Lactobacillus;Metagenomics;Methods;Metronidazole;Microbial Biofilms;Mucins;Mucous body substance;Mucous Membrane;novel;Oral;Outcome;Participant;Patients;Population;predictive marker;Premature Birth;prevent;Prospective cohort;Recommendation;Recording of previous events;recruit;Recurrence;Recurrent disease;Refractory;Refractory Disease;Regimen;Reporting;repository;reproductive;Research;Research Design;response;Risk;Sampling;Sexually Transmitted Diseases;Symptoms;Techniques;Time;TLR4 gene;Treatment outcome;treatment trial;Vagina;Vaginal Diseases;vaginal microbiome;vaginal microbiota;Variant;Virulence;Virulence Factors;Work

PROJECT_TITLE: Factors associated with Refractory and Early Recurrent Bacterial Vaginosis


ORG_CITY: Chicago

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Despite advancements in clinical awareness, sepsis continues to be a major global cause of death and incurs significant healthcare expenses. The study aims to address the issue of exaggerated immune responses leading to organ dysfunction and mortality by proposing innovative approaches to prevent inflammatory overreactions. The findings from these studies are expected to offer crucial insights for future clinical trials, holding great potential to enhance survival rates and treatment outcomes for septic patients.

PI_NAMEs: HU, GUOCHANG  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Address;Adoptive Transfer;Albumins;Alveolar Macrophages;Animal Genetics;Animal Model;Automobile Driving;Autophagocytosis;Awareness;Bacteremia;Binding;Biology;Blood;Bone Marrow;Bone Marrow Transplantation;Cause of Death;Cessation of life;Clinical;Clinical Trials;Complex;cytokine;Development;Diabetes Mellitus;Disease;Endoplasmic Reticulum;Exhibits;Experimental Models;Functional disorder;Future;Generations;Genes;Genetic;global health;Health Care Costs;Healthcare;Healthcare Systems;Human;IL18 gene;Immune response;Immune system;immunoregulation;improved;In Vitro;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;Injections;Injury;innovation;insight;Interleukin-1 beta;intravital microscopy;Knockout Mice;Knowledge;Life;Lung;lung injury;Macrophage;Malignant Neoplasms;marenostrin;Mediating;Metabolic Diseases;Methods;misfolded protein;Mitochondria;Molecular;monocyte;mortality;mouse model;Mus;NADP;nanoparticle;Nervous System Disorder;novel;novel therapeutic intervention;Nuclear;Nucleotides;Organ;organ injury;Outcome;overexpression;Oxidases;Oxidoreductase;Pathway interactions;Patient-Focused Outcomes;peripheral blood;Peripheral Blood Mononuclear Cell;pneumonia model;polymicrobial sepsis;prevent;Production;Reaction;Reactive Oxygen Species;receptor;Regulation;Research;Role;Safety;Sampling;Sepsis;septic;septic patients;Series;Signal Pathway;Signal Transduction;Small Interfering RNA;Survival Rate;systemic inflammatory response;targeted treatment;Techniques;Testing;therapeutic evaluation;therapeutic target;tissue injury;transcriptome sequencing;transcriptomics;Transplantation;Treatment Efficacy;Treatment outcome;Up-Regulation

PROJECT_TITLE: ER-phagy regulation of immune response: mechanisms and significance

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE Gram-negative bacterial pathogens, particularly Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli, and Enterobacter species are associated with life-threatening systemic infections which pose an enormous burden to the public health system. Their ability to rapidly develop drug resistance and propagate as multidrug-resistant, and now pan-resistant pathogens, begs the need for new agents that are not only highly efficacious and safe but able to overcome resistance to existing antibiotics in high-risk patient populations. In an effort to meet this challenge, we propose to develop a new class of antibiotics, the biamyxins, that we recently created as a highly effective countermeasure against this increasingly serious public health threat.

PI_NAMEs: ZHAO, YANAN  (contact)

PROJECT_TERMS: absorption;Acinetobacter;Acinetobacter baumannii;Acute;Address;ADME Study;Amino Acid Substitution;Anti-Bacterial Agents;anti-microbial drug;Antibiotic Resistance;Antibiotics;antimicrobial;Binding;Biological;Blood;carbapenem resistance;Carbapenem-resistant Acinetobacter;carbapenem-resistant Enterobacteriaceae;Centers for Disease Control and Prevention (U.S.);Classification;Clinical;clinical efficacy;Colistin;colistin resistance;Colony-forming units;combat;Contracts;cytotoxicity;design;Development;dimer;Dose;Dose Fractionation;drug candidate;Drug Kinetics;drug metabolism;Drug resistance;drug resistance development;drug synthesis;Enterobacter;Epithelium;Escherichia coli;Evaluation;Excretory function;Formulation;Funding;Goals;good laboratory practice;Good Manufacturing Process;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Half-Life;Health Expenditures;Health system;Healthcare Systems;healthcare-associated infections;high risk;Hospitals;Hour;Human;improved;In Vitro;in vivo;Infection;innovation;Investigational Drugs;Kidney;Klebsiella;Klebsiella pneumoniae;Lead;Life;Lipid A;Lipopolysaccharides;Liquid substance;Lung;Lung infections;manufacture;manufacturing organization;Membrane;Metabolism;meter;micronucleus;Modeling;Modern Medicine;Modification;monomer;mouse model;Multi-Drug Resistance;Mus;New Agents;novel;novel antibiotic class;Organ;pathogen;pathogenic bacteria;patient population;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacology;Pharmacology Study;Plasma;Pneumonia;Polymyxins;pre-clinical;priority pathogen;programs;Property;Pseudomonas;Pseudomonas aeruginosa;Public Health;Publishing;Qualifying;Resistance;resistant strain;Rodent;Safety;safety assessment;screening;Septicemia;Series;Structure;Structure-Activity Relationship;Systemic infection;Therapeutic;Therapeutic Agents;Tissues;Toxic effect;Toxicology;Treatment Efficacy;United States Dept. of Health and Human Services;World Health Organization

PROJECT_TITLE: Novel Biamyxins targeting multidrug resistant Gram-negative bacterial infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]