ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: OMAHA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: This proposed research is relevant to NIH’s mission because it will generate new knowledge about the  structure- activity- relationship and mechanism of action of new antischistosomal chemotypes. The project is  relevant to public health because the discovery of a new antischistosomal drug would be important in the  chemotherapy of schistosomiasis and likely be valuable in integrated control programs to curb this parasitic  disease.

PI_NAMEs: VENNERSTROM, JONATHAN L (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: adaptive immune response;Adolescent;Adult;Affect;Area;Binding Proteins;Biological Assay;Blood;Caco-2 Cells;chemotherapy;Country;cytotoxicity;Databases;design;Dose;drug action;drug candidate;drug development;Drug Kinetics;Drug resistance;experimental study;Feedback;genotoxicity;Goals;Human;Hydantoins;in silico;In Vitro;in vivo;indexing;Individual;Indoles;Infection;infection risk;innovation;Investigation;Knowledge;Lactams;Lead;Mediating;Metabolic;Microsomes;Mission;Mus;novel;novel therapeutics;Oral;Outcome;Parasites;Parasitic Diseases;Pathway Analysis;Periodicity;Permeability;Pharmaceutical Preparations;Plasma Proteins;Praziquantel;programs;Property;prospective;Protein Isoforms;Proteins;Public Health;Rattus;Research;Resistance development;Ring Compound;Role;Schistosoma;Schistosoma japonicum;Schistosoma mansoni;Schistosomiasis;Series;Solubility;Structure-Activity Relationship;Sulfonamides;Titrations;transcriptomics;Treatment Failure;Trematoda;United States National Institutes of Health;Work

PROJECT_TITLE: Optimization of Antischistosomal Chemotypes

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Rural Health

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE This UCDCCC UG1 program, to be pursued by an already well-established and accomplished multidisciplinary clinical research team, will provide scientific and administrative leadership to NCTN, while also ensuring robust accrual and access to NCTN trials throughout the North-Central California community. In summary, UCDCCC will provide an impactful contribution to NCTN's goal for improving human health through the quality completion of large innovative clinical trials across a wide range of tumor types.

PI_NAMEs: GANDARA, DAVID R (contact);VALICENTI, RICHARD

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Area;Awareness;biomedical referral center;Biometry;California;cancer care;Cancer Control;cancer prevention;career development;Clinical Research;Clinical Trials;Communities;Comprehensive Cancer Center;design;Ensure;experience;Faculty;Genomics;Goals;Health;Human;improved;innovation;Institution;Laboratories;Lead;Leadership;Link;Malignant Neoplasms;Medical Oncology;medical specialties;minority patient;Molecular Biology;multidisciplinary;NCI-Designated Cancer Center;Nursing Research;Pathology;patient population;Persons;Population;programs;Radiation Oncology;Radiology Specialty;Research Personnel;Research Support;Resources;rural patients;rural underserved;Site;Structure;Surgical Specialties;Translational Research;Translations;tumor

PROJECT_TITLE: UCDCCC NCTN UG1 PROGRAM


ADMINISTERING_IC: MH

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: ATHENS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Narrative  Early detection of young people at clinical high risk for psychosis offers a critical opportunity for early intervention to improve the course of illness, and perhaps even prevent onset entirely. Current interview-based methods for psychosis risk detection lack specificity, and are only available in a handful of research centers in the United States. The proposed study aims to improve accessibility and broaden impact of high risk screening by testing brief computerized measures, ultimately able to be administered on the internet, and to improve prediction by focusing on tasks specific to underlying mechanisms driving emerging psychotic symptoms.

PI_NAMEs: STRAUSS, GREGORY P (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;American;Attenuated;Automobile Driving;Behavioral;Biological Markers;Clinical;clinical high risk for psychosis;clinical practice;cognitive testing;Collaborations;computerized;Computing Methodologies;design;Detection;Deterioration;Diagnosis;Dimensions;Early Diagnosis;Early identification;Early Intervention;follow-up;Foundations;Frequencies;functional decline;Functional disorder;functional outcomes;Generations;Goals;help-seeking behavior;high risk;high risk population;Human Resources;improved;Individual;Internet;Intervention Trial;Interview;Joints;Link;Longitudinal Studies;Machine Learning;machine learning classification;machine learning method;Measures;Methods;Modeling;neural;Neurobiology;new therapeutic target;next generation;online delivery;Outcome;Participant;Patient Self-Report;Performance;Persons;Population;Predictive Value;prevent;preventive intervention;Primary Prevention;Psychopathology;Psychoses;psychosis risk;psychotic symptoms;Public Health;Publishing;Recording of previous events;recruit;Research;Research Personnel;Risk;Role;Sample Size;screening;Secondary Prevention;Severities;Site;social;Specificity;Symptoms;System;Techniques;Test Result;Testing;Training;trait;Translating;United States;Work;Youth

PROJECT_TITLE: 4/5 CAPER: Computerized assessment of psychosis risk


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Chronic Pain;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_DEPT: VETERINARY SCIENCES

PHR: Project narrative The overall goal of this project is to determine the mechanisms of mucosal host defense coordinated by sensory nociceptive neurons during enteric bacterial infection.

PI_NAMEs: REARDON, COLIN  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Ablation;adaptive immune response;Address;Affect;Afferent Neurons;American;Bacterial Infections;Blood;Bone Marrow;Cations;CCL19 gene;CD4 Positive T Lymphocytes;Cell Adhesion Molecules;cell motility;cell type;Cells;chemokine;Chemotaxis;Chimera organism;Citrobacter rodentium;Colon;Communication;Data;Dendritic Cells;Development;Diphtheria Toxin;Dissection;Endothelial Cells;Endothelium;Enteral;enteric infection;enteric pathogen;Enterocytes;enteropathogenic Escherichia coli;Epithelial Cells;Escherichia coli EHEC;Escherichia coli Infections;experimental study;Foundations;Gastrointestinal tract structure;Goals;health determinants;Hospitalization;Host Defense;host-microbe interactions;Human;Immune;immune function;Immune response;Immunity;Immunologics;In Vitro;in vivo;Induced Neurons;Infection;Infectious Skin Diseases;Inflammation;Injury;Innate Immune Response;innovation;interleukin-22;intestinal epithelium;Intestinal Mucosa;Intestines;Knowledge;Lamina Propria;Lung;Lung infections;Lymphatic Endothelial Cells;Lymphoid Cell;Mechanics;Mediating;member;migration;Modeling;Monitor;Morbidity - disease rate;mortality;Mucosal Immune Responses;Mucosal Immunity;Mucous Membrane;Mus;nerve supply;Neurogenic Inflammation;Neuroimmune;Neurokinin A;Neurons;neurotransmitter release;Neurotransmitters;Nociception;Nociceptors;novel;Outcome;pathogen;pathogenic bacteria;Pathogenicity Island;Peptides;Permeability;Physiological;prevent;Process;Production;protein expression;receptor;recruit;response;Role;Sensory;Skin;Source;Stimulus;Substance P;T-Lymphocyte;therapeutic target;Tissues;TRPV1 gene;Type III Secretion System Pathway;Vasodilation

PROJECT_TITLE: Coordination of mucosal immune response to enteric bacterial pathogens by nociceptive innervation

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Patient Safety;Precision Medicine;Rare Diseases;Stomach Cancer

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Gastric cancer (i.e., stomach cancer) is a major public health burden with a high incidence and mortality worldwide. In this project, we propose to develop computational imaging approaches to the prediction of treatment response and prognosis of gastric cancer. Success of our research may help select the most effective treatment for an individual patient, which will not only improve outcomes for patients in the US but also have global impact.

PI_NAMEs: LI, RUIJIANG  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Adopted;advanced disease;Aftercare;Age;Algorithms;Architecture;Biological;Blood;burden of illness;Cancer Etiology;cancer therapy;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;Clinical Data;Clinical Markers;clinical translation;Clinical Trials;clinically relevant;clinically significant;cohort;community setting;Curative Surgery;Data;deep learning;deep learning model;design;Development;Disease;Disease Surveillance;Distant;effective therapy;Evaluation;Failure;follow-up;Gender;Goals;Habitats;Heterogeneity;Histologic;Histology;Image;imaging approach;imaging biomarker;Imaging technology;Immune;Immunotherapy;improved;improved outcome;Incidence;Individual;individual patient;ineffective therapies;innovation;Integration Host Factors;Knowledge;Localized Disease;Location;longitudinal analysis;Machine Learning;Malignant Neoplasms;malignant stomach neoplasm;minority communities;Minority Groups;Modality;Modeling;Monitor;Morphology;mortality;multimodal data;multitask;Neoadjuvant Therapy;new therapeutic target;novel;Operative Surgical Procedures;Pathologic;Patient-Focused Outcomes;Patients;Performance;performance tests;personalized medicine;PET/CT scan;Population;predicting response;Prediction of Response to Therapy;predictive modeling;Process;Prognosis;prognostic;prognostic model;prognostic value;prospective;prospective test;Protocols documentation;Public Health;radiological imaging;radiomics;Recurrence;Reproducibility;Research;response;Risk;Risk Factors;risk prediction;risk stratification;Selection for Treatments;serial imaging;Serum Markers;side effect;Solid Neoplasm;Staging;standard care;Statistical Models;success;survival outcome;survival prediction;Systemic disease;Testing;therapy outcome;Toxic effect;Training;translational model;treatment response;tumor;tumor microenvironment;Uncertainty;Underserved Population;Validation;Work;X-Ray Computed Tomography

PROJECT_TITLE: Computational imaging approaches to personalized gastric cancer treatment

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Estrogen;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: POPULATION COUNCIL

ORG_STATE: NY

PHR: PROJECT NARRATIVE We plan to develop a multipurpose prevention technology (MPT) intravaginal ring (IVR) that releases a safe and effective combination of an estrogen, a progestin, and a non-ARV antiviral agent to prevent pregnancy and HIV infection. The unique IVR could reduce both the emergence of drug-resistant HIV and the concern of potential increased risk of HIV transmission associated with use of a progestin-only contraceptive.

PI_NAMEs: DERBY, NINA R.;FRIEDLAND, BARBARA A;TELESHOVA, NATALIA  (contact)

PROGRAM_OFFICER_NAME: CUMMINS, JAMES E

PROJECT_TERMS: Adherence;Adverse event;Anti-Retroviral Agents;Anti-retroviral resistance;Anti-viral Agents;anti-viral efficacy;Biological Assay;Biological Response Modifiers;Collaborations;Colposcopy;Computer Assisted;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Counseling;Couples;Cross-Over Studies;demographics;design;Development Plans;Diameter;diaries;Dose;Drug Delivery Systems;Drug Kinetics;efficacy study;Estrogens;Ethinyl Estradiol;Etonogestrel;Excision;experimental study;Fibroins;Formulation;Frequencies;Future;Hemorrhage;High Pressure Liquid Chromatography;High Risk Woman;HIV;HIV anti-retroviral;HIV drug resistance;HIV Infections;HIV resistance;Human;improved;In Vitro;in vivo;Infectious Pregnancy Complications;innovation;Instruction;Interview;Lead;Lectin;Levonorgestrel;Macaca mulatta;manufacture;Measurement;Measures;Menstruation;Methodology;non-drug;novel;parity;Pharmacodynamics;Pilot Projects;Placebos;Plasma;Population;preference;Pregnancy;prevent;Prevention;Process;product development;Progestins;Questionnaires;Reporting;reproductive tract;Research Design;Resistance;Resistance development;Risk;Safety;safety assessment;Science;Self Assessment;Serious Adverse Event;sex;Sex Behavior;side effect;Silicones;Silk;simian human immunodeficiency virus;social;Specific qualifier value;Technology;technology development;Testing;Text Messaging;Tissues;tool;transcriptome;transcriptome sequencing;transmission process;unintended pregnancy;Vagina;vaginal fluid;Vaginal Ring;Viremia;Virus Shedding;Woman;Women's Health;Work

PROJECT_TITLE: An Etonogestrel/Ethinyl Estradiol/QGriffithsin (ETG/EE/QGRFT) IVR to Prevent Pregnancy and HIV


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: OVERALL: PROJECT NARRATIVE The mission of the Southern California Environmental Health Sciences Center is to develop the scientific knowledge base, investigator teams, and community engagement that leads to reduced burden of disease and disability from environmental impacts on major health outcomes, especially among vulnerable populations.

PI_NAMEs: MCCONNELL, ROB S (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Academic support;Address;Air;Air Pollution;Area;base;Biological;Biological Process;Biometry;burden of illness;California;career;career development;Clinical;Collaborations;Communication;Communities;community engagement;Community Health;community involvement;community organizations;community partners;Complex;consumer product;Core Facility;critical developmental period;Data Science;Development;disability;Disease;Disparity population;Droughts;Early Diagnosis;Educational workshop;Elements;Environment;environmental change;Environmental Exposure;Environmental Hazards;Environmental Health;environmental health disparity;Environmental Impact;experience;Food;Fostering;Future;General Population;Goals;Government Officials;Growth;Health;health literacy;Health protection;health science research;Health Sciences;heat island;human disease;improved;innovation;Integration Host Factors;Integrative Medicine;Interdisciplinary Study;International;Intervention;knowledge base;learning community;Life Cycle Stages;Malignant Neoplasms;Mediating;Metabolic;Methods;Mission;Modeling;Molecular;multidisciplinary;National Institute of Environmental Health Sciences;Neurologic;next generation;novel;Obesity;Outcome;Outcomes Research;Pathway interactions;Pilot Projects;Policies;Policy Maker;Population;Positioning Attribute;Predisposition;Professional Organizations;programs;Public Health;recruit;Research;Research Methodology;Research Peer Review;Research Personnel;Research Project Grants;Resources;response;Science;Scientist;Series;social;social disparities;Soil;Strategic Planning;Structure;success;symposium;Translating;Translational Research;trend;Urbanization;Vulnerable Populations;Water;Wildfire;working group

PROJECT_TITLE: Environmental Exposures, Host Factors and Human Disease

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P0)]


NIH_SPENDING_CATS: Social Determinants of Health

PROJECT_TERMS: Advisory Committees;Area;base;Biometry;burden of illness;California;career;career development;clinical application;Collaborations;Communication;Communities;community advisory board;community engagement;Consultations;Core Facility;Data Science;disability;Educational workshop;Electronic Mail;Environment;Environmental Exposure;Environmental Health;Environmental Impact;Evaluation;Event;Fees;Fostering;Funding;Goals;Grant;Health;health science research;Health Sciences;human disease;Infrastructure;innovation;Institution;Integration Host Factors;Integrative Medicine;Interdisciplinary Study;International;knowledge base;Leadership;Malignant Neoplasms;meetings;Metabolic;Mission;Modeling;Monitor;National Institute of Environmental Health Sciences;Needs Assessment;Neurologic;Obesity;organizational structure;Outcome;Outcomes Research;Performance;Periodicals;Pilot Projects;Productivity;Program Development;programs;Public Health;Publications;Recommendation;Records;recruit;Reproducibility;Research;Research Methodology;Research Personnel;Research Support;Resources;Role;Science;Scientist;Series;Services;skills;social media;Structure;success;symposium;Talents;Translational Research;Translations;United States National Institutes of Health;Update;Vision;vision science;web site;webinar;working group

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Immune checkpoint blockade (ICB) treatment has played a pivotal role in cancer therapy but only benefits a minority of patients. While growing numbers of studies have emphasized the microbiota's contribution to ICB clinical response, there is a struggle to elucidate immunological mechanisms – an issue compounded by the lack of consensus in microbes reported among studies, as well as different tumor models and cancer types used between studies. This collaborative grant proposal investigates multiple tumor models and ICBs using germfree and gnotobiotic mice to understand how generalizable microbiome influences on ICB are across disparate tumor models and cancer types, as well as identify ICB-inhibitory effector species and possible mechanisms through which the intestinal microbiota can be modified in cancer patients and unlock immunotherapy to its fullest potential.

PI_NAMEs: SHANG, JOAN  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: adaptive immunity;Animals;anti-CTLA4;anti-PD-1;anti-PD-L1;anti-PD-L1 therapy;Applications Grants;Attenuated;Automobile Driving;Bacteria;cancer care;Cancer Model;Cancer Patient;cancer therapy;cancer type;checkpoint inhibition;Clinical;Clinical Research;Clinical Trials;Colorectal Cancer;Communities;Consensus;Data;Disease;Disparate;draining lymph node;dysbiosis;Exhibits;experimental study;Failure;fecal transplantation;fighting;Flow Cytometry;Future;Germ-Free;Gnotobiotic;Goals;Grant;gut microbiota;Health;Hematologic Neoplasms;Human;human microbiota;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immune system;Immunologics;immunoregulation;Immunotherapy;improved;Individual;insight;interest;Intervention;Investigation;Knowledge;Laboratory Finding;Link;Malignant Neoplasms;MC38;Measures;Melanoma;Methods;Microbe;microbial;microbial community;microbiome;microbiome research;microbiota;Minority;Modeling;mouse model;Mus;Myelogenous;Natural Immunity;novel;Outcome;patient response;Patients;Phase;Play;Population;Reporting;Research;Research Personnel;responders and non-responders;response;Role;Solid;Standardization;stool sample;T-Lymphocyte;targeted treatment;Therapeutic;Treatment Efficacy;treatment response;trend;tumor;tumor growth;tumor xenograft;Work;Xenograft procedure

PROJECT_TITLE: Dissecting the Gut Microbiota for Immune Checkpoint Blockade (ICB) - Resisting Microbes and Exploring the Generalizability of Microbiota-ICB Studies


ADMINISTERING_IC: DK

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Many current recommendations for dietary intake (DI) and physical activity (PA) to maintain optimal health and minimize risks for chronic health conditions, such as obesity and type 2 diabetes (T2D), are based on statistical analyses of data prone to measurement error, including those collected from self-reported questionnaires and wearable devices. To overcome these barriers, we will develop new and robust statistical methods to 1) identify latent groups of PA patterns based on device-based functional curves prone to heteroscedastic measurement errors and determine the association between the identified PA patterns with T2D status adjusting for PA biomarkers, age, sex, and race/ethnicity; 2) better reduce the impact of measurement error-related biases in PA and DI data on the quantile functions of body mass index and fat mass index; and 3) correct for measurement error biases associated with device-based PA and self- reported DI when evaluating their influences on T2D status. These newly developed models and related software will be widely applicable in studies of objective measures of PA and DI in chronic health conditions, which can lead to more targeted and effective interventions and address health outcomes disparities among vulnerable populations in various biomedical contexts.

PI_NAMEs: TEKWE, CARMEN D. (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Accelerometer;Address;Adult;Affect;Age;analytical method;Behavior;Biological Markers;Biomedical Research;Body mass index;Characteristics;Chronic;Classification;Clinical;Complex;Complex Mixtures;Computer software;Data;Data Set;Databases;Demographic Factors;design;Devices;Dietary intake;discrete time;effective intervention;Energy Intake;Ensure;Ethnic Origin;Evaluation;Failure;Fatty acid glycerol esters;Food;Frequencies;Health;health outcome disparity;high dimensionality;improved;indexing;insight;Intake;Intervention;Life Style;Linear Regressions;Measurement;Measures;Methodology;Methods;Modeling;modifiable behavior;Monitor;National Health and Nutrition Examination Survey;Noise;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Obesity;Outcome;Patient Self-Report;Pattern;Performance;Physical activity;Population Heterogeneity;Precision Health;Process;Property;Public Health;Questionnaires;Race;Recommendation;Regression Analysis;Research;Research Personnel;risk minimization;Role;Sampling;semiparametric;Sensitivity and Specificity;sex;simulation;software development;Statistical Data Interpretation;Statistical Methods;Statistical Models;Subgroup;Testing;time interval;Validation;Variant;Vulnerable Populations;wearable device;Work

PROJECT_TITLE: Measurement error correction approaches to wearable device-based measures of physical activity and self-reported measures of dietary intake in obesity and type 2 diabetes research

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative The proposed research is relevant to public health because there is an unmet need to develop new treatment approaches for patients with Hutchinson-Gilford Progeria Syndrome, an incurable genetic disease. As such, the proposed research is highly relevant to the mission of the NIH that seeks to support biomedical research that will improve human health and reduce the burden of disease and disability.

PI_NAMEs: BROWN, JONATHAN DAVID (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: 2 year old;5 year old;Address;Adenine;Adolescent;Adult;Age;Age Months;aging related disease;Animals;Aorta;Atherosclerosis;Automobile Driving;base editing;base editor;Base Pairing;Benchmarking;Biomedical Research;Birth;Blood Vessels;burden of illness;causal variant;Cell Count;Cell Death;Cell Separation;Cells;Cessation of life;Child;Clinical Trials;Clonality;cohort;curative treatments;Data;Defect;Dependovirus;disability;Disease;disease phenotype;DNA;DNA Damage;DNA strand break;Dominant-Negative Mutation;Dose;Endothelial Cells;Fibroblasts;Fibrosis;Future;gene therapy;Genes;Genetic;Genetic Diseases;Genome;Health;Hepatic;Heterozygote;Human;human disease;humanized mouse;Immune response;improved;Injections;innovation;juvenile animal;Lamin Type A;Lead;Leukocytes;Maps;mature animal;Measures;Messenger RNA;Mission;Modeling;Molecular;mortality;mouse model;Multiple Organ Failure;Mus;mutant;Mutation;Nature;Newly Diagnosed;novel therapeutic intervention;Nucleotides;older adult;Outcome;Paracrine Communication;Pathogenicity;Pathology;Patients;Phenotype;Point Mutation;Population;Pre-Clinical Model;preclinical efficacy;premature;prevent;Prevention;Production;Progeria;Proliferating;protein expression;Protein Truncation;Public Health;Publishing;Recovery;Research;RNA Editing;RNA Splicing;Saline;senescence;single-cell RNA sequencing;Smooth Muscle Myocytes;Syndrome;Techniques;Testing;Therapeutic;Time;time use;Tissues;Translating;treatment strategy;tumorigenesis;United States National Institutes of Health;Validation;Vascular Diseases;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;Work

PROJECT_TITLE: Gene Therapy in Hutchinson-Gilford Progeria Syndrome

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Genetics;Human Genome;Social Determinants of Health

PI_NAMEs: ALLAYEE, HOOMAN  (contact)

PROJECT_TERMS: Address;Animal Model;Animals;Archives;Area;Basic Science;Biological;Biological Assay;Biological Models;Biometry;California;Cardiovascular system;Cell model;Center for Translational Science Activities;Chemicals;Clinical;Clinical Investigator;Clinical Research;Communities;community engagement;community partners;Consultations;Core Facility;cost effective;Data;data integration;design;Development;Disease;Dose;Environment;environmental chemical;Environmental Exposure;Environmental Health;Environmental Impact;epigenomics;Equipment;Etiology;Exposure to;Expression Profiling;gene environment interaction;genome-wide;Genomics;Genotype;Health;health assessment;health data;health science research;Health Sciences;Human;Human body;human disease;Human Subject Research;improved;In Vitro;in vitro Model;Individual;Infrastructure;Institution;Institutional Review Boards;instrumentation;Integration Host Factors;Integrative Medicine;Interdisciplinary Study;Laboratories;Life Cycle Stages;Link;Malignant Neoplasms;Measurement;meetings;member;Metabolic;metabolomics;Methodology;Molecular;Molecular Biology;Molecular Epidemiology;Molecular Genetics;Molecular Profiling;Neurologic;next generation;novel;Outcome;Outcome Assessment;Pathway interactions;Performance;Pilot Projects;Policy Maker;Population;population based;Population Sciences;Preparation;Process;Productivity;programs;Proteomics;protocol development;Quality Control;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;research vision;Resources;respiratory;response;sample collection;Sampling;Science;Services;Source;Technical Expertise;Technology;Testing;Tissues;tool;Training;Translating;translational approach;Translational Research;Translations;Work

PROJECT_TITLE: Integrative Health Sciences Facility Core


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Dental, Oral, and Craniofacial Disease;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NORMAN

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Narrative When someone suffers a severe brain injury, a portion of the skull must be removed so that the brain can swell. Unfortunately, a second surgery is required to replace that missing piece of the skull, and the patient can experience neurological problems up until the day that missing bone is replaced. In a rat model, we believe that placing our new flexible material during the first surgery that can later turn into bone will still allow the brain to swell initially, while avoiding the second surgery and the neurological problems.

PI_NAMEs: ANDREWS, BRIAN T;DETAMORE, MICHAEL S. (contact);NUDO, RANDOLPH J.

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: 3D Print;Acceleration;Address;animal model selection;Animals;Anti-Inflammatory Agents;Anxiety;Area;base;Behavior;Behavioral;Biocompatible Materials;biomaterial development;Biomedical Engineering;bioprinting;bone;Bone Matrix;Bone Regeneration;bone repair;Brain;Brain Edema;Brain Injuries;Calvaria;Caring;Cartilage;Cause of Death;Cephalic;Cessation of life;Clinic;Clinical Trials;Closed head injuries;Cognitive;Complication;Control Groups;craniofacial bone;cranium;cranium plastic repair;crosslink;Crosslinker;Custom;Data;Defect;demineralization;design;disability;Drug Delivery Systems;Edema;Emergency department visit;Encephalitis;Evaluation;experience;fascinate;Female;flexibility;Formulation;Goals;Headache;healing;Histology;Hospitalization;Hyaluronic Acid;Hydrogels;Implant;improved;improved outcome;In Vitro;in vivo;in vivo evaluation;Industry;innovation;interest;Intracranial Pressure;Left;Letters;Life;local drug delivery;Magnetic Resonance Imaging;male;Medical;Mental Depression;Modeling;Modernization;Motor;motor deficit;multidisciplinary;Mus;Musculoskeletal;Neurologic;Neurologic Deficit;neurological recovery;neurosurgery;Neurosurgical Procedures;nonhuman primate;novel;Operative Surgical Procedures;Organ;Osteoblasts;osteogenic;particle;particle exposure;Paste substance;Patients;Pharmaceutical Preparations;Pliability;preservation;Procedures;Process;Property;Rattus;Recovery;Regenerative Medicine;Resolution;Rheology;Scalp structure;Solid;Speed;standard of care;Stroke;Surgeon;Survivors;Swelling;Symptoms;synergism;TBI Patients;TBI treatment;Tendon structure;Testing;Thinness;Time;Tissues;tool;translational impact;Traumatic Brain Injury;Ultraviolet Rays;United States;virtual

PROJECT_TITLE: Single stage surgical intervention for treatment of severe traumatic brain injury

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Primary Health Care;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE An increasing number of patients with serious mental illness receive care in Medicaid Accountable Care Organizations (ACOs), an alternative payment model in which global payments and quality benchmarks are used to incentivize quality and lower spending, but little evidence exists on quality of ACO care for this patient population. We propose to identify features of Medicaid ACOs (e.g. provider-led vs. hospital-led ACOs) that produce the highest quality ACO care for adults with serious mental illness. We will compare stability of enrollment, care quality, and patient experience between differing ACO types using mixed methods, including quantitative analysis of claims data and qualitative interviews with patients and case managers.

PI_NAMEs: GOLDMAN, ANNA  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: accountable care organization;Address;Adult;Affect;Ambulatory Care;American;barrier to care;Benchmarking;care coordination;career development;Caring;Case Manager;Cessation of life;Characteristics;Chronic Care;comorbidity;Data;Development Plans;Drops;Enrollment;Evolution;experience;Funding;General Population;Goals;Health;health care delivery;health care service organization;Health Insurance;Health Policy;Health Services Accessibility;Healthcare;Homelessness;Hospital Administrators;hospital readmission;Hospitals;improved;Incentives;Individual;insight;Insurance Claim Review;Interview;Investigation;Leadership;Low income;Massachusetts;Measures;Medicaid;Medical;Medicare;Mental Health;Methods;Modeling;National Institute of Mental Health;Natural experiment;Organizational Affiliation;Organizational Models;Outcome;parity;participant enrollment;Patient Care;patient population;Patients;payment;Perception;Policies;Policy Maker;Population;premature;programs;Proliferating;Provider;Quality Indicator;Quality of Care;Randomized;Research;Research Personnel;risk selection;Selection Bias;severe mental illness;Shapes;social;social adversity;social vulnerability;Source;Strategic Planning;Structure;System;tool

PROJECT_TITLE: Medicaid Accountable Care Organizations (ACO) and Quality of Care for Adults with Serious Mental Illness (SMI)


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Glaucoma is the most common neurodegenerative disease in the world and there are no treatments to prevent or rescue the degenerative cascades that lead to blindness. We discovered a neuroprotective lipid mediator pathway in the healthy retina that is disrupted in disease. This project will define the regulation and mechanism of these lipid signals and develop therapeutic methods to restore their protective function in order to stop or prevent glaucoma.

PI_NAMEs: FLANAGAN, JOHN G;GRONERT, KARSTEN  (contact);SIVAK, JEREMY M

PROGRAM_OFFICER_NAME: HENLE, STEVEN JOHN

PROJECT_TERMS: Acute;adeno-associated viral vector;Affect;American;analog;Astrocytes;biological adaptation to stress;Biological Assay;Blindness;Cell Death;Cell Physiology;Cell Survival;Cells;Chronic;Clinical;Complex;Disease;Drug Targeting;Etiology;experimental study;Family;FPR2 gene;gene-targeted therapy;Glaucoma;Goals;Health;Healthcare Systems;Homeostasis;Human;In Vitro;in vivo;Inflammation;Inflammatory;Injury;insight;lipid mediator;lipidomics;Lipids;lipoxin A4;lipoxin B4;Lipoxin Receptors;Lipoxins;liquid chromatography mass spectrometry;LOX gene;Mediating;Mediator;metabolomics;Methods;Mitochondria;Modeling;Molecular;mouse model;Muller's cell;Nature;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurons;Neuropathy;neuroprotection;Neuroprotective Agents;neurotoxic;neurotransmission;neurovascular;novel;Optic Disk;Optic Nerve;optic nerve disorder;Paracrine Communication;Pathogenesis;Pathway interactions;Persons;pharmacologic;Phenotype;Physiologic Intraocular Pressure;prevent;programs;receptor;Regulation;Research;Research Project Grants;response;response to injury;Rest;Retina;Retinal Degeneration;Retinal Diseases;retinal ganglion cell degeneration;Retinal Ganglion Cells;Role;screening;selective expression;Signal Transduction;Stress;Stretching;Testing;Therapeutic;therapeutic target;Tissues;transplant model;Treatment Efficacy;Treatment Protocols;Vascular Endothelial Cell

PROJECT_TITLE: Homeostatic Role and Therapeutic Potential of the Neuroprotective Retinal Lipoxin Circuit

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ORG_CITY: CHARLESTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE High prevalence of intestinal diseases, such as colon cancer, suggests that we still don’t fully understand their underlying causes. We have discovered a mechanism linking colon tissue integrity, which is commonly compromised in these diseases, with regulation of cell behavior, through molecules called microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). The current proposal will provide insights into the regulation and role of this mechanism in maintenance of colon homeostasis, which could lead to novel diagnostic and therapeutic approaches for intestinal diseases.

PI_NAMEs: KOURTIDIS, ANTONIS  (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Adherens Junction;Anchorage-Independent Growth;Architecture;Behavior;Biology;cell behavior;cell transformation;Cell-Cell Adhesion;Cells;Cellular Structures;Code;Colon;colon cancer cell line;colon cancer progression;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;Complex;Data;Development;Disease;Disease Progression;E-Cadherin;Epithelial Attachment;Epithelial Cells;Epithelium;experimental study;Foundations;gastrointestinal;High Prevalence;Homeostasis;In Vitro;in vivo;Incidence;Inflammatory Bowel Diseases;innovation;insight;Intestinal Cancer;Intestinal Diseases;Knowledge;Link;Maintenance;Malignant Neoplasms;Messenger RNA;metaplastic cell transformation;Microprocessor;MicroRNAs;Molecular;novel;novel diagnostics;novel therapeutic intervention;Oncogenic;overexpression;Pathway interactions;Patients;Phenotype;Precancerous Conditions;promoter;Publishing;recruit;Regulation;Research;RNA;RNA Interference;RNA-Induced Silencing Complex;Role;Sampling;Testing;therapeutic RNA;Tissues;tool;transcriptome sequencing;tumor;tumorigenesis;tumorigenic;Untranslated RNA;Up-Regulation;Work

PROJECT_TITLE: Epithelial adherens junctions regulate colon cell behavior through RNAi and lncRNAs

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: GAUDERMAN, WILLIAM JAMES (contact)

PROJECT_TERMS: Big Data;big data management;Bioinformatics;Biometry;California;career development;Categories;Chalk;cluster computing;Collaborations;Communities;community based participatory approach;community based participatory research;community engagement;Complex;Complex Analysis;Computer Analysis;Computer Hardware;Computer software;Computer Systems;Computing Methodologies;Consultations;Continuing Education;Core Facility;cost effective;Data;data access;Data Analyses;data mining;data resource;Data Science;Databases;Development;Education;Educational workshop;Ensure;Environmental Exposure;Environmental Health;epigenomics;experience;experimental study;Faculty;falls;Gene Expression;Genomics;Genotype;Geographic Information Systems;Goals;Government Agencies;Grant;health science research;Health Sciences;Human;human disease;Human Resources;human subject;improved;Information Dissemination;Institution;Integration Host Factors;Integrative Medicine;Link;metabolomics;Methodology;Methods;Mission;Monitor;monitoring device;National Institute of Environmental Health Sciences;novel;Paper;Pilot Projects;Postdoctoral Fellow;Process;Program Development;programs;Proteomics;Publishing;Qualifying;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Resources;Sample Size;Science;Scientific Advances and Accomplishments;Services;Source;Statistical Data Interpretation;Statistical Methods;statistical service;Students;System;Technology;technology platform;Training;Translating;Visualization;Work

PROJECT_TITLE: Biostatistics Facility Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: NARRATIVE These studies will examine neural circuit-based mechanisms for understanding emotional instability across appetitive and aversive behaviors in BD. Focus on circuit- and cell-specific roles of Wnt/β catenin and stress/reward-related molecular pathways may be transformative in our understanding of BD and point to novel interventions and therapeutic approaches.

PI_NAMEs: BERRETTA, SABINA  (contact);MCCARROLL, STEVEN ANDREW;RESSLER, KERRY J.

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Affect;Affective;Algorithms;Amygdaloid structure;Anhedonia;Anti-Anxiety Agents;Anxiety;Appetitive Behavior;Arousal;Autopsy;Behavior;beta catenin;Bipolar Disorder;Cell Nucleus;cell type;Cells;Clinical;Data;Desire for food;Dimensions;Disease;Electronic Health Record;Emotional;Fingerprint;Fright;Gene Expression;Genetic;Genetic Models;Goals;Health;Hormones;Human;Image;Impulsive Behavior;Intercalated Cell;Intervention;knock-down;Knock-out;Label;Lateral;Link;Lithium;Manic;Mental Depression;Mental disorders;Messenger RNA;Modeling;Molecular;Molecular Abnormality;Molecular Profiling;motivated behavior;mouse genetics;Mus;National Institute of Mental Health;neural circuit;neuronal circuitry;Neurons;Neurotensin Receptors;novel;Nucleus Accumbens;optogenetics;Pathway interactions;Pattern;Persons;Phenotype;pleasure;Population;protein expression;Proteins;Research Domain Criteria;Resolution;response;reward processing;Rewards;RNA;Rodent;Role;segregation;Severities;Signal Transduction;Signaling Molecule;single nucleus RNA-sequencing;single-cell RNA sequencing;Stress;Symptoms;System;Testing;Therapeutic;transcriptome sequencing;WNT Signaling Pathway

PROJECT_TITLE: Dysregulation of Appetitive & Aversive Amygdala Circuits in Bipolar Disorder

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Eczema / Atopic Dermatitis;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Orthopoxviruses;Rare Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative This grant proposal will determine the impact of the pathogen, Staphylococcus aureus (which is commonly present on the skin of atopic dermatitis patients), on systemic inflammation (measured in the circulation), response to treatments, and viral skin infections in atopic dermatitis patients. Lastly, we have designed experiments to determine if a bacterium called Cutibacterium acnes, commonly present on the skin of healthy individuals and remarkably reduced in atopic dermatitis patients, may function to suppress the growth of the pathogen, Staphylococcus aureus.

PI_NAMEs: BECK, LISA ANN (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acne;Affect;Applications Grants;Atopic Dermatitis;Bacteria;Biological;Biological Markers;Biology;biomarker identification;biomarker panel;Cells;Child;Circulation;Clinical;clinical predictors;commensal bacteria;Coupled;Data;Eczema Herpeticum;Eczema Vaccinatum;enhancing factor;Enrollment;Epithelium;experience;Experimental Designs;Exposure to;Fatality rate;Functional disorder;gene product;Genome;Growth;Human;Immune Targeting;Immunity;Individual;Infectious Skin Diseases;Inflammatory;Measures;Mediating;Microbe;microbiome;pathogen;Pathogenesis;Patients;permissiveness;Phenotype;Play;Predisposition;Production;prospective;Publications;recruit;Registries;response;Ribosomal RNA;Role;Serum;Severities;Severity of illness;Simplexvirus;Site;Skin;skin barrier;Skin colonization;skin disorder;skin microbiome;skin microbiota;Smallpox;Smallpox Vaccine;Staphylococcus aureus;Surface;systemic inflammatory response;Systemic Therapy;Testing;treatment response;Vaccination;Vaccinia virus;Viral;Virulence Factors;Virulent;Virus Diseases

PROJECT_TITLE: Biomarker Identification, Viral Susceptibility and Management in S. aureus Colonized AD Patients


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Rigorous evaluation of how parents shape their children’s behavior has major implications for our understanding of family functioning and motivates policies or interventions promoting specific parenting practices. We propose examining the intergenerational impact of marijuana use and disorder using two complementary natural experiments in 6,457 individuals from 1,902 families in Colorado and Minnesota. We will use the children of twins design to test the extent of direct environmental impact of parents while controlling for genetic confounds, and conduct a state-by-state comparison of parental and adolescent marijuana use and disorder, parenting practices, and family environment, leveraging the marked differences in marijuana laws and substance use norms in Colorado and Minnesota.

PI_NAMEs: KELLER, MATTHEW CHARLES;RHEE, SOO H (contact);VRIEZE, SCOTT IAN;WILSON, SYLIA

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: 18 year old;21 year old;addiction;Address;Adolescence;Adolescent;Adolescent marijuana use;adolescent substance use;Adult;Attenuated;Attitude;Behavior;behavioral disinhibition;Cannabis policy;Caregivers;Child;Child Behavior;Child Rearing;Collaborations;Colorado;Conflict (Psychology);Controlled Study;cost effectiveness;Data;design;Disease;Disinhibition;District of Columbia;Environment;Environmental Impact;Evaluation;Family;Genetic;Hereditary Disease;Human Development;Impulsivity;Individual;innovation;intergenerational;Intervention;Lead;Legal;Link;Longitudinal Studies;Marijuana;marijuana legalization;marijuana use;marijuana use disorder;Measures;Medical;Minnesota;Modeling;Monitor;Natural experiment;next generation;Nuclear Family;Observational Study;Parents;Participant;Policies;Prevention;Preventive;Process;prospective;Public Policy;Recreation;recruit;Research Design;Risk;Risk Taking;Sampling;Schedule;Shapes;Socialization;substance use;Substance Use Disorder;Testing;theories;Time;transmission process;Twin Multiple Birth;Twin Studies;United States

PROJECT_TITLE: Understanding the links between parental and adolescent substance use:complementary natural experiments using the children of twins design

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: HABRE, RIMA  (contact)

PROJECT_TERMS: Address;Affect;Air Pollution;Behavior;Behavior assessment;Biological;Biological Monitoring;Biometry;built environment;California;Categories;Chemicals;Collaborations;Communication;community engagement;community organizations;community partnership;Complex;Consultations;Continuing Education;Core Facility;cost effective;Data;data acquisition;Data Analyses;Data Collection;data quality;data resource;Data Science;Databases;design;Development;digital;Discipline;Dose;Ecological momentary assessment;Education;Educational workshop;Environment;environmental chemical;Environmental Exposure;Environmental Health;Equipment;experience;falls;Funding;Geographic Information Systems;Geography;Grant;Health;health science research;Health Sciences;Human body;human disease;Imagery;improved;Individual;Institution;instrument;Integration Host Factors;Integrative Medicine;interest;Life Cycle Stages;Light;Logistics;Machine Learning;Manuscripts;Measurement;Measures;Methodology;Methods;Mission;Modeling;Molecular Profiling;Monitor;National Institute of Environmental Health Sciences;next generation;Noise;novel;operation;Outcome;Outcomes Research;Pathway interactions;Pilot Projects;Population Research;Postdoctoral Fellow;Process;programs;Protocols documentation;psychosocial;Psychosocial Assessment and Care;Qualifying;Quality Control;Recommendation;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;response;Sampling;Science;Services;social;Social Environment;software systems;Source;spatiotemporal;stressor;Students;System;Technology;Time;tool;Training;Ultraviolet Rays;UV Radiation Exposure;Work

PROJECT_TITLE: Exposure Factors Facility Core


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Schizophrenia is a chronic disorder and is among the most highly disabling diseases in all of medicine, impacting approximately 1.5% of the population. This study will use novel state-of-the-art electroretinography, optical coherence tomography and angiography imaging to capture retinal biomarkers that inform pathophysiology and clinical associations in early course schizophrenia. This study is expected to have an impact on the growing consensus in psychiatry and neuro-ophthalmology that the retina provides a window into the brain that can be useful for understanding brain pathophysiology and for developing biomarkers of illness progression and possibly treatment response.

PI_NAMEs: LIZANO, PAULO L (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Affect;Anatomy;Angiography;Animals;Antipsychotic Agents;Area;Biological Markers;biological research;biomarker validation;Blood Vessels;Brain;brain magnetic resonance imaging;brain volume;Cell Physiology;Cells;Cellular biology;Central Nervous System;cerebral atrophy;Cerebrum;Cessation of life;Chronic;Chronic Disease;Chronic Schizophrenia;Clinical;clinically relevant;Cognition;Cognitive;Collaborations;comorbidity;comparison control;Consensus;cost effective;Data;Development;Diagnostic;Diameter;Dimensions;disabling disease;disease classification;Dropout;Ear;Early Intervention;Electroretinography;experience;Eye;Functional disorder;Functional Imaging;Functional impairment;functional loss;ganglion cell;Ganglion Cell Layer;Goals;gray matter;Health Care Costs;Histologic;Human;imaging approach;Imaging Device;imaging study;Imaging technology;Impaired cognition;in vivo;indexing;Infrastructure;injured;Injury;Inner Plexiform Layer;Israel;Lateral Geniculate Body;Link;Magnetic Resonance Imaging;Measures;Medical center;Medicine;Meta-Analysis;Methods;Morphology;multidisciplinary;multimodality;Nerve Degeneration;Nerve Fibers;neuroimaging;neuropsychiatry;Neurosciences;novel;Nuclear;Occipital lobe;Ophthalmology;Optical Coherence Tomography;Outcome;outcome prediction;outer plexiform layer;Pathology;Patients;Perfusion;personalized intervention;Phenotype;Photoreceptors;Physiologic Intraocular Pressure;Population;Process;Psychiatry;Psychopathology;Psychoses;Psychotic Disorders;psychotic symptoms;Research;Resolution;Resources;responsible research conduct;Retina;Retinal Ganglion Cells;retinal imaging;retinal nerve fiber layer;Retrograde Degeneration;Role;Schizophrenia;Selection for Treatments;Structural defect;structural imaging;Structure;Structure-Activity Relationship;Symptoms;Synapses;Technology;Testing;Thalamic structure;therapy resistant;Thick;Thinness;Time;Tissues;tool;Training;Training Programs;Trans-Synaptic Degeneration;treatment response;Universities;venule;vision science;Visual;Visual Cortex;Visual impairment;Visual Pathways;visual processing;Visual System;Work

PROJECT_TITLE: Retinal Layer, Microvascular and Electroretinographic Determinants of Early Course Schizophrenia

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Liver Disease;Skin Cancer

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Melanoma is an aggressive cancer with an increasing incidence. Metastatic melanoma to the liver is frequent and associated with poor prognosis and resistance to novel therapies, such as immunotherapies. The current study will use novel models, methodologies and a large cohort of patient biopsies to elucidate the molecular underpinnings of the development of liver metastasis and how these lesions confer resistance to immunotherapies. This will inform rationale design of novel therapeutic avenues for patients with metastatic melanoma to the liver.

PI_NAMEs: IZAR, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: advanced disease;Animals;Antibodies;Biological Markers;Biopsy;Brain;cancer cell;cancer immunotherapy;CD4 Positive T Lymphocytes;CD8B1 gene;cell motility;Cell Physiology;cell type;Cells;Cellular Metabolic Process;Clinical;cohort;Communities;CRISPR screen;CRISPR/Cas technology;Dependence;design;Development;Disease;Disseminated Malignant Neoplasm;Drug Design;drug development;Drug resistance;Environment;exome;experimental study;Flow Cytometry;Frequencies;Functional disorder;gene product;Genetic;Genome engineering;Genomics;Glucose;Goals;Hematogenous;Human;Image;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune System Diseases;Immunotherapy;Impairment;improved;in vivo;Incidence;inhibitor;innovation;Insulin;Insulin Receptor;insulin signaling;Knock-out;Lesion;Liver;liver biopsy;liver development;Lung;lymph nodes;Lymphatic;Malignant Neoplasms;Measurement;Mediating;Melanoma;Melanoma Cell;Melanoma patient;metabolomics;Metastatic Melanoma;Metastatic Neoplasm to the Liver;Metastatic Neoplasm to the Lung;Methodology;Methods;Modeling;Molecular;mouse model;multiplexed imaging;Mus;Mutation;Neoplasm Metastasis;neoplasm resource;novel;novel therapeutics;Organ;Pancreas;Pathway interactions;Patients;Pattern;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Pharmacotherapy;phosphoproteomics;Phosphorylation;Physiological;PI3K/AKT;PIK3CG gene;Population;Pre-Clinical Model;Primary Neoplasm;Prognosis;Proto-Oncogene Proteins c-akt;Research;Resistance;response;Role;Route;sample collection;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Site;Survival Rate;T-Lymphocyte;Testing;transcriptomics;treatment response;tumor growth;Variant;Xenograft Model

PROJECT_TITLE: Mechanisms of liver metastasis and associated resistance to immunotherapy

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ORG_CITY: VANCOUVER

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF BRITISH COLUMBIA

ORG_STATE: BC

ORG_ZIPCODE: V6T 1Z3

PHR: Narrative Massive effort has been expended collecting gene expression profiling data in attempts to understand human brain function and disease, but interpreting these data remains a challenge. In this project we build on our investigations in which we re-analyze thousands of published studies to add insights, develop new analytic approaches, and provide databases, tools and data to the neuroscience research community to improve gene expression and gene network analysis. By applying our approaches to disorders of the brain such as schizophrenia and autism, we will increase understanding of the molecular underpinnings of these human conditions.

PI_NAMEs: PAVLIDIS, PAUL  (contact)

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: Accounting;Address;Affect;autism spectrum disorder;Binding;Biological;Biological Models;Brain;brain cell;Brain Diseases;Candidate Disease Gene;candidate identification;cell type;Cells;ChIP-seq;Chromatin;chromatin immunoprecipitation;Collection;Communities;complex data;Complication;Computer software;Data;Data Analyses;data curation;Data Set;Data Sources;Databases;Development;differential expression;Disease;Expression Profiling;Face;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Expression Regulation;gene function;gene network;Genes;Genetic;genetic association;Genetic study;genomic data;Genomics;Human;human disease;improved;Individual;insight;Investigation;Knowledge;Literature;Manuals;Meta-Analysis;Methods;Molecular;Morphologic artifacts;Motivation;Nervous System;neuroinformatics;neuropsychiatry;Neurosciences;Neurosciences Research;Output;Pathway Analysis;Pattern;Positioning Attribute;Process;Publishing;Quality Control;Regulation;Regulatory Pathway;Research;Resolution;Resources;Role;Sampling;Schizophrenia;Series;Signal Transduction;single cell genomics;Societies;software development;Source;Specificity;Systems Biology;Technology;Tissues;tool;transcription factor;transcriptome;transcriptomics;Variant;web app;Work

PROJECT_TITLE: Neuroinformatics for gene expression: networks, function and meta-analysis

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: JOHNSTON, JILL E (contact)

PROJECT_TERMS: Address;African American population;Air;air monitoring;Air Pollution;Asian;Awareness;California;Chemicals;Collaborations;Communication;Communication Methods;Communities;community advisory board;community engagement;community organizations;community partners;community science;Consultations;Core Facility;Data;Democracy;design;Development;digital;Economics;Educational workshop;empowerment;Environment;environmental disparity;Environmental Exposure;Environmental Health;environmental health disparity;environmental justice;Environmental Protection;Equity;Evaluation;Exposure to;Fostering;Goals;Health;health disparity populations;health literacy;Health Professional;Home;Human;human disease;Individual;Industrialization;Industry;innovation;Integration Host Factors;Justice;land use;Language;Latinx;Logic;marine;Metals;Methods;Mission;Modeling;Movement;multi-ethnic;Multilingualism;Neighborhoods;novel;Oils;Online Systems;operation;Pacific Islander;Policies;Policy Maker;Pollution;Printing;Process;programs;Public Health;Public Policy;Recycling;Research;Research Personnel;Research Support;Resources;Role;Schools;Science;Science Policy;skills;social disparities;social media;Social outcome;Structure;success;Techniques;tool;Training;Transportation;Update;Visualization;Work;Youth

PROJECT_TITLE: Community Engagement Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Obesity;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative Obesity is a rapidly increasingly problem in the US that increases health care costs, reduces quality of life, and reduces productivity of millions of Americans. It is one of the greatest threats to public health. Finding ways to stop increases in obesity and to reverse current trends requires intensive scientific study. Program faculty on this training grant have successfully mentored 23 promising young scientists in the last eight years, all of whom have been actively involved and productive in multidisciplinary research and 17 of whom have already matriculated. The proposed renewal will continue to provide the training necessary to fill this need.

PI_NAMEs: KOTZ, CATHERINE M (contact);LASKA, MELISSA N.;SHERWOOD, NANCY E.

PROGRAM_OFFICER_NAME: KAMARA, FANTA

PROJECT_TERMS: Minnesota;obesity prevention;Training

PROJECT_TITLE: Minnesota Obesity Prevention Training (MnOPT)

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: Nashville

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative This program provides a uniquely translational and interdisciplinary training opportunity for scientists in the field of Communication Sciences and Disorders. The training is designed to address critical challenges facing the field including a national shortage of PhD level researcher, increased need for translational, interdisciplinary, and cross-methodological training, and a lack of training in implementation science and health equity. The overarching goal of the program is to prepare a number of highly trained and qualified researchers who are well-equipped to address the challenges facing the field of Communication Sciences and Disorders.

PI_NAMEs: DUFF, MELISSA C (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TITLE: Translational Interdisciplinary Research Training in Communication Sciences and Disorders


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Children in Sub-Saharan Africa are burdened by significant unmet mental health needs, including disruptive behavior disorders that persist through adolescence and adulthood if left untreated. The proposed study will examine the mechanisms by which economic empowerment and family strengthening interventions targeting social, familial and context-specific drivers affect the mental health of children in mid-upper primary schools in Uganda. Findings from this study can inform group, community and population approaches that are needed for scalable solutions to address the social drivers negatively impacting child behavioral health in low-resource settings, including in Sub-Saharan Africa.

PI_NAMEs: MCKAY, MARY MCKERNAN;SSEWAMALA, FRED M (contact)

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescence;adolescent mental health;Adult;Affect;Africa;Africa South of the Sahara;African;Behavioral;behavioral health;Caregivers;Child;Child Development;Child Mental Health;Child Rearing;Childhood;cohesion;Collaborations;Communities;community setting;design;Disruptive Behavior Disorder;Economics;empowerment;experience;Faith;Family;Family Process;financial literacy;Food;food insecurity;forging;Ghana;Health;help-seeking behavior;HIV/AIDS;Housing;improved;Incentives;Income;Institution;Intervention;intervention effect;Investments;Kenya;Knowledge;Left;Letters;longitudinal design;Mediating;Mediator;Mental Health;Mental Health Services;Mentorship;Parent-Child Relations;Participant;Perception;physical conditioning;Play;Policies;Population;population based;Poverty;Prevalence;Primary Schools;programs;Public Health;Randomized;Research;Resource-limited setting;Resources;response;Role;safety net;Savings;Schools;Scientist;social;social influence;social stigma;Stream;Symptoms;System;systematic review;Systems Theory;Testing;theories;therapy design;Time;Training;treatment arm;Uganda;World Health Organization;Youth

PROJECT_TITLE: Suubi(Hope)4StrongerFamilies: Addressing Child Behavioral Health by Strengthening Financial Stability and Parenting among Families in Uganda


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Estrogen;Genetics;Nutrition;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE This project explores how the sex-specific steroid hormone, ecdysone, promotes intestinal stem cell proliferation, gut expansion, and metabolic changes in reproductive Drosophila females. We also test the hypothesis that sex- specific steroids regulate progenitor cell proliferation and adaptive gut growth in mice. These studies will advance our knowledge of how steroid signaling affects the sex-biased incidence of stem-cell based diseases including cancers, inflammatory conditions, degenerative and metabolic diseases.

PI_NAMEs: EDGAR, BRUCE ALEXANDER (contact)

PROJECT_TERMS: Address;Affect;Arthropods;Atlases;Binding Sites;Biological Assay;Breast;cell behavior;cell growth;Cell Proliferation;cell type;Cells;ChIP-seq;Chronic Disease;Colorectal Cancer;conditional knockout;Data;Degenerative Disorder;Diabetes Mellitus;Diagnosis;Disease;Drosophila genus;Dysplasia;Ecdysone;ecdysone receptor;Ecdysterone;Enterocytes;Environment;Epidermal Growth Factor Receptor;Epithelial Cell Proliferation;Epithelial Cells;Estradiol;experimental study;Fat Body;Female;Fertility;Fertilization;fitness;fly;Future;Gastrointestinal tract structure;Gatekeeping;Gene Expression;Gene Targeting;Genes;Genetic;Gonadal Steroid Hormones;Growth;Health;Hormones;Human;human disease;human stem cells;Hyperactivity;in vivo;Incidence;Inflammation;Inflammatory;insight;intestinal epithelium;intestinal homeostasis;Intestines;Knowledge;Lead;Learning;life span;Malignant Neoplasms;malignant stomach neoplasm;Mammals;Maps;Measures;Mediating;Mediator;Metabolic;Metabolic Diseases;Metabolism;Methods;Midgut;Mitogens;Modeling;Morphology;Mus;novel;Nutrient;nutrition;Nutritional;Obesity;Organ;organ growth;Organoids;Ovary;overexpression;Partner in relationship;Physiological;Physiology;Play;postmitotic;Predisposition;Probability;progenitor;Progesterone;Prostate;receptor;Reproduction;reproductive;reproductive fitness;reproductive organ;Risk;RNA Interference;Role;Route;sex;Sex Bias;sexual dimorphism;Signal Transduction;single-cell RNA sequencing;Sports;stem cell growth;stem cell proliferation;stem cell self renewal;stem cells;steroid hormone;Steroid Receptors;Steroids;Testing;Testis;Testosterone;transcriptome sequencing;tumorigenesis;uptake;Uterus;Work

PROJECT_TITLE: Sex steroid signaling and adaptive growth of the intestine

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Data Science;Emerging Infectious Diseases;Genetics;Infectious Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases;Vector-Borne Diseases;West Nile Virus;Zika Virus

ORG_CITY: LOS ANGELES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Combating rapidly evolving pathogens, such as Ebola, SARS-CoV-2, West Nile and Zika viruses, and their associated disease burden is a tremendous challenge requiring sustained research effort and deliberate public health measures. Viral genome sequencing and phenotyping from infected individuals as an outbreak unfolds has the potential to guide intervention and clinical management, if the phylodynamic toolset can scale to 1000s of samples. This proposal aims to develop scalable statistical models and computational tools to provide this data integration and equips us for large-scale epidemics and pandemics.

PI_NAMEs: SUCHARD, MARC A. (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: 2019-nCoV;Adoption;Africa;Algorithms;Applications Grants;Attention;Bayesian Method;Biological;Biology;burden of illness;Clinical;Clinical Management;cohort;combat;Communicable Diseases;Communities;comparative;Computer software;computerized tools;Data;data integration;Data Science;Data Set;data streams;design;Development;disability;Disease;Disease Outbreaks;Ebola;Ebola virus;Epidemic;Evolution;Factor Analysis;Fever;Fostering;genome sequencing;Genomics;Genotype;graduate student;Health Policy;Heterogeneity;high dimensionality;HIV;Human;Human Resources;immunodeficiency;improved;Individual;Infectious Disease Epidemiology;Influenza;influenzavirus;innovation;International;Intervention;invention;Joints;Lassa;Lassa virus;Libraries;Link;Manufacturer;Maps;Marriage;Measurement;Measures;Medicine;Methods;minority scientist;Modeling;Molecular Epidemiology;multidisciplinary;next generation;novel;pandemic disease;parallel computer;pathogen;pathogen genome;pathogenic bacteria;Peer Review;Performance;Phenotype;phenotypic data;Phylogenetic Analysis;Productivity;Public Health;Publishing;reconstruction;Research;Sampling;Sampling Errors;Science;Scientist;Statistical Computing;Statistical Models;statistics;Suggestion;Techniques;Technology;theories;Thinking;Time;Touch sensation;Training;trait;transmission process;Transportation;Trees;undergraduate student;Underrepresented Minority;Underrepresented Populations;user friendly software;Viral;Viral Genome;West Nile;West Nile virus;Woman;Work;Zika Virus

PROJECT_TITLE: Statistical innovation to integrate sequences and phenotypes for scalable phylodynamic inference


NIH_SPENDING_CATS: Clinical Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PI_NAMEs: MCCONNELL, ROB S (contact)

PROJECT_TERMS: Address;Applications Grants;Area;Biometry;burden of illness;California;career;career development;catalyst;Collaborations;community based participatory research;community engagement;community partnership;Consultations;Core Facility;cost effective;Data;Development;disability;Environmental Exposure;Environmental Health;Environmental Impact;Feedback;Fostering;Funding;Funding Opportunities;Growth;health science research;Health Sciences;human disease;Incubators;Individual;innovation;Integration Host Factors;Integrative Medicine;Interdisciplinary Study;knowledge base;Mission;new technology;novel strategies;Physicians;Pilot Projects;Play;Process;Program Development;programs;Public Health;recruitment science;Research;Research Personnel;Research Support;Role;Science;Scientist;Services;success

PROJECT_TITLE: Pilot Projects Program


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Climate-Related Exposures and Conditions;Lung;Microbiome;Prevention;Rare Diseases;Regenerative Medicine;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE This research will provide fundamental information on the impact of O3 and ultrafine CB inhalation co-exposure on ALI pathogenesis and will discern how co-exposure differ from individual particle/gaseous exposures in inducing aggravated/differential lung injury. We anticipate identifying key mechanistic pathways in lung progenitor (AT2) cells which alter epithelial regeneration in ALI after environmental insults. In the short term, this research will quantify pulmonary responses to separate vs co-exposure to a gaseous and particulate constituent of the environmental pollution, and in the longer term, it will help to reduce the burden of environmental diseases by providing evidence on whether current single toxicant exposure-based regulations are sufficient to protect workers and the general population.

PI_NAMEs: HUSSAIN, SALIK  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: 3-Dimensional;Acute;Acute Lung Injury;adverse outcome;Aerosols;Air Pollution;Alveolar;alveolar epithelium;Animal Model;Apoptosis;Attention;Automobile Driving;Binding;Biological;Bleomycin;Breathing;Carbon;Carbon Black;Cells;Characteristics;Clinical;Death Rate;Dependence;Development;Disease;Dose;Drops;dysbiosis;Engineering;Environmental Exposure;Environmental Impact;Environmental Pollution;Environmental Risk Factor;epithelial injury;Epithelium;epithelium regeneration;Exhibits;Exposure to;Free Radicals;Functional disorder;Gases;Gene Expression;General Population;Genetic;Genetically Modified Animals;Goals;gut microbiome;gut-lung axis;Health;Impairment;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Response;Inhalation;Inhalation Exposure;Injury;injury and repair;Knockout Mice;Knowledge;Life;Lung;Lung Diseases;lung injury;lung microbiome;lung regeneration;Mediating;microbial;microbiome;Mitochondria;mitochondrial dysfunction;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Natural regeneration;novel;Nucleotides;Organoids;Outcome;Oxidants;Oxidative Phosphorylation;Oxidative Stress;Ozone;particle;Particulate;particulate pollutant;Pathogenesis;Pathology;Pathway interactions;Permeability;Phase;Population;Predisposition;prevent;Preventive;Production;progenitor;programs;Proliferating;protein expression;Public Health;pulmonary function;pulmonary function decline;Pulmonary Inflammation;receptor;Regulation;Reporting;Research;Respiration;response;Role;Standardization;stem cell niche;stem cells;Surface;Syndrome;Therapeutic;therapeutic target;Time;Toxic effect;Toxicant exposure;tropospheric ozone;Ultrafine;ultrafine particle;World Health Organization

PROJECT_TITLE: Impact of particle and ozone inhalation co-exposure on alveolar epithelial regeneration


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Genetics;Mental Health;Pain Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative The public health relevance of this project lies in its comprehensive approach to studying the genetic and environmental contributions to the development of chronic pain among twins across childhood and adolescence. The results gleaned from this study of a large, ethnically-diverse sample of community-dwelling twins will yield a better understanding of the influences of stress exposure, emotion dysregulation, and epigenetics on youth's pain, and of the potential for social resilience to buffer risk for pain development. Thus, findings will help clinical scientists interested in pediatric pain prevention and resilience by identifying critical developmental periods, and targets for intervention efforts.

PI_NAMEs: DAVIS, MARY COLLEEN (contact);LEMERY-CHALFANT, KATHRYN

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: 16 year old;Address;Adolescence;Adolescent;Adult;Aerobic;Age;aging gene;Arizona;Behavioral Genetics;Benign;Biological Markers;Birth Records;boys;Buffers;Calibration;Child;Child Development;Childhood;chronic pain;Chronic pain syndrome;chronic painful condition;Clinical;clinical pain;clinically significant;Communities;critical developmental period;Data;design;Development;diaries;early childhood;early life adversity;Electronics;emotion dysregulation;emotion regulation;Environment;Environmental Impact;Epidemiology;Epigenetic Process;ethnic diversity;Ethnic Origin;Etiology;Exposure to;Family;follow up assessment;Frequencies;Funding;Future;Genes;Genetic;genetic association;Genetic Risk;Genetic study;girls;Glean;Growth;Health;Health behavior;Health Psychology;Heritability;High Prevalence;hypothalamic-pituitary-adrenal axis;Immune;infancy;interest;Intervention;Learning;Life;Link;Literature;Mediating;Methodology;Methods;Methylation;methylation pattern;middle childhood;Modeling;Monozygotic twins;Muscle;novel;optimism;Pain;Pain Disorder;Pain Measurement;parent project;Parents;Personality;Prevalence;prevent;Prevention;Process;Puberty;public health relevance;Questionnaires;Recovery;Recurrent pain;Research;resilience;Risk;Risk Factors;risk mitigation;Role;Sampling;Scientist;Sex Differences;sleep quality;social;social relationships;Socioeconomic Status;Stress;stress management;Symptoms;System;Time;transmission process;Twin Multiple Birth;Youth

PROJECT_TITLE: Genetic and Environmental Origins of the Development of Pain in Children

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of renal failure, affecting over 600,000 individuals in the United States alone and more than 12 million people worldwide. This research will provide novel insights into the mechanisms of cyst formation by evaluating and discovering candidates regulating cystogenesis using cutting edge multidisciplinary approaches including biochemistry, bioinformatics, cell biology, genetics, human cell models, and animal models of the disease. This research will evaluate a new drug target and likely discover new ones.

PI_NAMEs: ZHOU, JING  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Actins;Adult;Affect;Animal Disease Models;Animal Model;Autosomal Dominant Polycystic Kidney;Biochemical;Biochemistry;Bioinformatics;bioinformatics tool;Biological;Biological Models;casein kinase;Cell model;cell motility;cell type;Cells;Cellular biology;Cilia;clinical care;comparative;Complement;Complex;Coupled;Cultured Cells;Cyclic AMP;Cyst;Cytoplasm;Cytoskeletal Modeling;Cytoskeleton;Data;Defect;design;Development;directional cell;Disease;disease model;Disease Progression;Drug Targeting;Epithelium;ERBB2 gene;Event;Excision;experimental study;FRAP1 gene;G-Protein-Coupled Receptors;gastrulation;Genes;Genetic;Genetic Crosses;Goals;Growth;Human;Image;In Vitro;in vivo;in vivo imaging;Individual;innovation;insight;Integrins;Intercalated Cell;interdisciplinary approach;Kidney;Kidney Failure;Knock-out;Knockout Mice;Liver;Mediating;Modeling;Molecular;mouse model;Mus;Mutation;Neonatal;Neurons;new therapeutic target;NF-kappa B;novel;Pathway interactions;Peptide Signal Sequences;Persons;Phenotype;Phosphoproteins;planar cell polarity;polycystic kidney disease 1 protein;Population Control;postnatal;Probability;Proprotein Convertase 2;protein complex;Protein Deficiency;protein function;Protein Kinase C;protein protein interaction;Proteins;Proteome;Proteomics;Protocols documentation;receptor internalization;receptor recycling;Regulation;Renal tubule structure;Reporting;Research;Role;Signal Pathway;Signal Transduction;STAT3 gene;survivin;System;Tamoxifen;Technology;Testing;Therapeutic;trafficking;United States;Vesicle;Wasps;water channel

PROJECT_TITLE: Modulation of cystogenesis

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Nutrition;Obesity

ORG_DEPT: NUTRITION

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative Obesity and metabolic syndrome and the associated complications of these disorders including type 2 diabetes mellitus, liver, kidney, and cardiovascular disease affect a large number of Americans. Nearly 40% of adults and over 20% of adolescents in the US are obese. Our training program is designed to prepare the next generation of biomedical scientists to work in multidisciplinary teams that bring together an in depth understanding of nutrition, metabolism, cell biology and genomics to address this critical public health problem.

PI_NAMEs: GREENBERG, ANDREW S (contact)

PROJECT_TERMS: Metabolic Diseases;nutrition;Obesity;Research Training;Training Programs

PROJECT_TITLE: Research Training Program in Nutrition, Obesity and Metabolic Disorders

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

PHR: Project Narrative During brain tumor surgery, brain tissue surrounding the tumor can deform by as much as two centimeters due to shifting of the brain making safe and effective tumor removal challenging. Several approaches have been developed that allow compensation for this deformation by non-rigidly registering preoperative imaging to the shape of the brain during surgery. This project will investigate ways to convey uncertainty in the non-rigid registration to surgeons, thereby allowing them to make more informed decisions during tumor resections to help maximize the extent of tumor resection while minimizing damage to surrounding tissue.

PI_NAMEs: FRISKEN, SARAH ;GOLBY, ALEXANDRA J;WELLS, WILLIAM M. (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Algorithms;anatomic imaging;Area;Awareness;Brain;Brain Neoplasms;brain shape;brain tissue;brain tumor resection;Clinical;Clinical Data;Compensation;Complex;Data;Data Set;Databases;Decision Making;design;dynamic system;Environment;Excision;feature detection;Functional Imaging;Glioma;Goals;Image;image guided;image guided therapy;image registration;Image-Guided Surgery;improved;innovation;insight;Institution;Institutional Review Boards;Investments;Location;Maps;Measurement;Measures;Methods;Modeling;Modernization;Multimodal Imaging;Navigation System;Neurologic Deficit;Neuronavigation;Neurosurgeon;neurosurgery;novel;open source;Operating Rooms;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Physics;Prognosis;Radiation therapy;Reproducibility;Research;Residual Neoplasm;Risk;shared database;Soft Tissue Neoplasms;software development;Spatial Distribution;Structure;Surgeon;Surgical Instruments;Surgically-Created Resection Cavity;System;Technology;technology development;Testing;Tissues;tumor;ultrasound;Uncertainty;Visualization;Work

PROJECT_TITLE: Ultrasound based neurosurgical navigation with uncertainty visualization

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Proper folding of proteins underlies nearly every aspect of cellular function and physiology and is ensured by the protein homeostasis (proteostasis) network. Defects in proteostasis result in protein aggregation, a hallmark of neurodegenerative diseases such as Alzheimer's, Parkinson's and ALS, while an overactive proteostasis network can support cancer cell growth and tumor progression. In support of the NIH mission, the research proposed here aims to elucidate the fundamental regulatory mechanisms, feedback loops, and organizational principles that govern the proteostasis network in healthy cells to gain insight into the ways it breaks down and is hijacked in disease.

PI_NAMEs: PINCUS, DAVID  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Alanine;Alzheimer's Disease;Amino Acids;Architecture;Binding;Binding Sites;Biochemistry;Biological Assay;C-terminal;cancer cell;Cancer Cell Growth;Cell Death;cell growth;Cell Physiology;Cells;Cellular biology;Cellular Stress;chromatin immunoprecipitation;Complex;Cytosol;cytotoxic;Defect;Disease;Dissociation;DNA;DNA Binding;Ensure;Equilibrium;Eukaryota;Event;experimental study;Feedback;fitness;gene conservation;Gene Expression;Genes;Genetic Transcription;Goals;Heart;Heat-Shock Response;Homologous Gene;HSF1;Human;human disease;Huntington Disease;insight;Laboratories;Lead;Life;Ligands;Link;Maintenance;Malignant Neoplasms;Mediating;Mission;Modeling;Molecular;Molecular Chaperones;Molecular Genetics;Monitor;mutant;Mutation;N-terminal;Nerve Degeneration;Neurodegenerative Disorders;novel;Nucleoplasm;Organelles;Orphan;overexpression;Parkinson Disease;Pathology;premature;programs;protein aggregation;Protein Biosynthesis;protein folding;protein misfolding;Proteins;proteostasis;Quality Control;rapid growth;Recombinant Proteins;Regulation;Repression;Research;response;Ribosomal Proteins;Ribosomes;Saccharomycetales;Series;Signal Transduction;Site;Stress;Surface;Surveys;Systems Biology;Tail;Testing;Therapeutic;Threonine;tool;Transactivation;transcription factor;Transcriptional Regulation;tumor progression;United States National Institutes of Health;Work;Yeasts

PROJECT_TITLE: Regulatory Dynamics of the Proteostasis Network

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIVERSITY LOS ANGELES

PHR: The U-RISE program at Cal State LA will significantly increase the participation of underrepresented groups in biomedical research leadership positions. The project will identify and develop creativity and intellectual talents of motivated trainees from groups traditionally underrepresented in biomedical research and strengthen their academic and research credentials through 1) mentored research, 2) entering research curriculum, 3) faculty mentor training in inclusivity, and 4) building scientific identity with community, so that they are highly competitive for admission to and success in top PhD programs.

PI_NAMEs: FOSTER, KRISHNA L (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Biochemistry;Biological Sciences;Biomedical Research;broadening participation research;career;CCL7 gene;Chemistry;college;Communities;computer science;Country;Degree program;design;Development;Doctor of Philosophy;Eligibility Determination;Engineering;Enrollment;Ethics;experience;Faculty;Grant;Health;Human;Infrastructure;innovation;investigator training;Learning;Mentors;Natural Sciences;Participant;programs;Research;Research Support;Research Training;responsible research conduct;Scientist;Services;skills;Social Sciences;student training;Students;symposium;Technology;Training Programs;undergraduate research;undergraduate student;United States National Institutes of Health

PROJECT_TITLE: Undergraduate Research Training for Student Enhancement (U-RISE) at Cal State LA

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: LAY ABSTRACT Malaria continues to exert a heavy toll on global heath. However, if better preventative drugs were available, it is possible that malaria might be eliminated. Better protective antimalarials are also needed by the traveling public and the military. Our objective is to create better drugs that prevent malaria and which are easier to use.

PI_NAMEs: WINZELER, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acetyl Coenzyme A;ADME Study;Amino Acyl-tRNA Synthetases;Anemia;animal efficacy;Animal Model;Animals;Anti-malarials;asexual;base;Binding Proteins;Biological Assay;Blood;Cell Culture Techniques;Cells;Cerebral Malaria;Cessation of life;Chemoprevention;Chemoprophylaxis;Chemoprotective Agent;Clinical;clinical candidate;Clinical Trials;Cluster Analysis;Culicidae;Data Set;design;Development;Dihydrofolate Reductase;Dihydroorotate dehydrogenase;Disease;Drug Design;drug development;Drug Kinetics;Drug resistance;efficacy testing;Erythrocytes;Evolution;Family;genome analysis;Genomics;Goals;Human;In Vitro;Infection;inhibitor;Injectable;International;Intramuscular Injections;Investigation;large datasets;lead optimization;Liver;Luciferases;Malaria;malaria infection;Malaria prevention;Medicine;Metabolic;meter;Methods;Microsomes;Military Personnel;Mitochondria;model organism;mouse model;next generation;novel;Oral;Parasite resistance;Parasites;Parasitology;Patients;Persons;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Plasmodium;Plasmodium falciparum;Plasmodium vivax;Population;predictive modeling;predictive test;prevent;Prodrugs;prophylactic;Prophylactic treatment;Proteins;Proteomics;Public Health;Research Personnel;scaffold;screening;Series;Severities;small molecule;Structure;symptom treatment;Testing;Therapeutic antibodies;therapy development;tool;Toxic effect;Travel;vaccine-induced antibodies;whole genome;Work

PROJECT_TITLE: Discovery of long-acting, chemoprotective antimalarial compounds

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(02)M]


NIH_SPENDING_CATS: Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: KENNESAW

ORG_NAME: KENNESAW STATE UNIVERSITY

PHR: NARRATIVE Caused by the parasite Trypanosoma brucei, human African trypanosomiasis (HAT) is a neglected tropical disease that is in need of effective, non-toxic drugs. We have identified a class of proliferation inhibitors with promising potency, selectivity, and pharmacokinetic profiles that represent a new chemical series for HAT drug discovery. This proposal outlines a medicinal chemistry optimization project that will deliver lead compounds for new HAT therapeutics, as well as an understanding of the mechanism of action of the leads.

PI_NAMEs: FERRINS, LORI ;MENSA-WILMOT, KOJO A. (contact)

PROJECT_TERMS: Achievement;African Trypanosomiasis;analog;aqueous;Binding Proteins;Biological Availability;Brain;Cells;Characteristics;Chemicals;chemotherapy;clinical candidate;counterscreen;Data;Disease;disease model;DNA Synthesis Inhibition;Dose;Drug Controls;drug discovery;Drug Kinetics;Drug Targeting;efficacy testing;Endocytosis;Evaluation;expectation;FDA approved;Funding;Genes;Hand;Haptoglobins;Hemoglobin;HepG2;Human;human model;in silico;In Vitro;indexing;inhibitor;knock-down;lapatinib;Lead;Life;Maximum Tolerated Dose;Metabolism;Molecular;molecular phenotype;Monitor;mouse model;Mus;neglected tropical diseases;novel therapeutics;Oral;overexpression;Parasitemia;Parasites;Pathway interactions;Penetrance;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenocopy;Phenotype;Physiological;pre-clinical;prevent;Proliferating;Property;Proteins;Proteome;Proteomics;Regimen;Safety;scaffold;Series;Shapes;Solubility;Structure;Testing;Therapeutic;Tissues;Toxic effect;Trypanosoma;Trypanosoma brucei brucei;Trypanosoma brucei rhodesiense;virtual library;Work

PROJECT_TITLE: Optimization and Modes of Action of NEU-4438, a New Anti-trypanosome Lead Drug

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-A(02)M]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Outcomes of gliomas, the most common type of primary brain tumors in adults are highly infiltrative with poorly defined margins, such as time to progression vary considerably, even for patients with the same pathological grade and recent studies have indicated that more uniform outcomes are observed in sub-groups of glioma with molecular markers such as IDH, 1p19q, ATRX, p53 and MGMT. The recent development of the consensus Brain Tumor Imaging Protocol (BTIP) has reduced the variability between scans but the lack of specificity and ambiguities in interpreting changes in anatomic images remains to evaluate 1) the extent of the disease, 2) the integrity of the blood-brain-barrier (BBB), and 3) response to treatment. The integration of 1H and 13C metabolic imaging into the acquisition protocol enables a more direct assessment of the biological properties of the lesion and has been shown to improve the evaluation of changes in the spatial extent of tumor associated with response to therapy.

PI_NAMEs: CHANG, SUSAN M;CHEN, ALBERT ;LI, YAN ;XU, DUAN  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Address;Adoption;Adult;Algorithms;anatomic imaging;Area;Atlases;ATRX gene;Biological;Biological Markers;Blood - brain barrier anatomy;Brain;Brain region;brain tumor imaging;Carbon;Characteristics;Classification;Clinical;clinical imaging;Clinical Trials;Clinical Trials Design;Combined Modality Therapy;Communities;Community Clinical Oncology Program;Complex;Computer software;Consensus Development;Data;design;Development;Digital Imaging and Communications in Medicine;Disease;Drug Delivery Systems;drug testing;Edema;Eligibility Determination;Evaluation;feature extraction;follow-up;Funding;Gadolinium;Glioma;Gliosis;Goals;Healthcare;Image;imaging approach;Imaging Device;improved;industry partner;Institution;Lesion;Machine Learning;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant - descriptor;Measurement;Metabolic;metabolic imaging;metabolic profile;MGMT gene;Modeling;Molecular;molecular marker;Monitor;neuro-oncology;novel;open source;Outcome;Pathologic;Patient-Focused Outcomes;Patients;Performance;personalized medicine;Prediction of Response to Therapy;Primary Brain Neoplasms;Property;Protocols documentation;Protons;Radiology Specialty;recruit;Reproducibility;Research;research clinical testing;Residual Neoplasm;Resolution;response;Scanning;serial imaging;Signal Transduction;Software Tools;Specificity;standard of care;Standardization;Subgroup;Summary Reports;Technology;Testing;Time;Tissues;tool;TP53 gene;Translating;treatment effect;treatment planning;treatment response;treatment strategy;tumor;Tumor Burden;tumor heterogeneity;Variant;Visual;white matter;Work

PROJECT_TITLE: Quantitative Steady-State and Dynamic Metabolic MRI for Evaluating Patients with Glioma


ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative To discover novel pharmaceuticals and elucidate of critical biological pathways, there is an urgent need to invent chemical methods enabling rapid and modular access to diverse chemical space from simple starting materials. This proposal outlines new chemical transformations based on the affordable nonmetal element sulfur to strengthen our ability to access complex molecules of relevance to the pharmaceutical industry.

PI_NAMEs: QIN, TIAN  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Development of Sulfur-Based Reactions with Translational  Applications

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_STATE: CA

PHR: NARRATIVE To help train the next generation of culturally diverse environmental health scientists improve the current environmental landscape that contributes to disparate health burdens, develop approaches to identify and evaluate environmental health disparities, and build skills in community-engaged research and research translation to improve public health, we introduce the “Environmental Health MethodologicAl, Training, and Teaching EnterpRiSe” (EH MATTERS) program. Leveraging the diverse student body at the University of Southern California, EH MATTERS will engage consecutive cohorts of underserved students in two-year training regimens that provide robust interdisciplinary training and research experiences to enable them to meaningfully contribute to addressing environmental health and justice issues in their respective communities.

PI_NAMEs: AUNG, TUN (MAX) M;JOHNSTON, JILL E (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: academic program;Address;Affect;African American;Air;Area;Bachelor's Degree;burden of illness;California;Career Choice;Chronic Disease;cohort;college;Color;Communities;community engaged research;community engagement;community organizations;community violence;consumer product;Data;Dedications;design;Development;didactic education;disability;Disease;Disparity;Documentation;Economic Development;Educational process of instructing;Educational workshop;Elements;Employment;Enrollment;Ensure;Environment;environmental chemical;environmental disparity;Environmental Epidemiology;Environmental Exposure;Environmental Hazards;Environmental Health;environmental health disparity;environmental justice;Epidemiology;Equilibrium;experience;Exposure to;Faculty;faculty research;Food;Fostering;Foundations;Funding;Future;Generations;Geographic Locations;Grant;Green space;hazard;Health;health disparity;health equity;Health Food;Health Status;Hispanic Americans;Housing;Human;improved;Inequity;innovation;Interdisciplinary Study;interest;International;Knowledge;Leadership;Learning;Legitimacy;life span;Los Angeles;Low income;Mentors;Mentorship;Methodology;Minority Groups;mosaic;Motivation;multidisciplinary;Neighborhoods;next generation;Occupations;Outcome;Persons;Population;Positioning Attribute;Postdoctoral Fellow;postgraduate education;Poverty;Preventive Medicine;programs;Public Health;Quality of life;Race;racism;Recording of previous events;recruit;Regimen;Research;Research Personnel;Research Project Grants;research study;Research Training;resilience;Role;Scientist;skill acquisition;skills;social capital;Socioeconomic Status;socioeconomics;Soil;student participation;Students;success;Talents;tool;Traineeship;Training;Training and Education;training opportunity;Training Programs;Translational Research;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underserved Population;underserved students;Unemployment;Universities;Urbanization;Water

PROJECT_TITLE: Environmental Health MethodologicAl, Training, and Teaching EnterpRiSe (EH MATTERS)