ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NORTHRIDGE

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: PROJECT NARRATIVE This interdisciplinary research will provide a better understanding of the relationship between social determinants and biological mechanisms during the transitional period of late adolescence to young adulthood. Our findings could have strong implications for social justice measures as well as public health interventions to curb cardiometabolic disease. By studying interpersonal discrimination and the results of environmental racism as stressors, we begin to deconstruct the psychosocial and physical costs of allostatic load for Latinx youth so that future interventions will be approached not only from an individual, but also at a systemic level.

PI_NAMEs: TOLEDO-CORRAL, CLAUDIA MICHELE (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Advocate;Age;allostatic load;ambient air pollution;Area;Awareness;Behavior;Biological;biological adaptation to stress;Biological Markers;Brain;built environment;burden of illness;California;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;catalyst;Chronic;Chronic Disease;Clinical;Communities;Complex Mixtures;cost;Data;Data Collection;design;Development;diabetes risk;Diet;Discrimination;Disease;disorder risk;Environmental Exposure;Environmental Impact;environmental justice;Environmental Protection;Environmental Risk Factor;environmental stressor;Epidemiology;epidemiology study;ethnic difference;ethnic discrimination;ethnic disparity;Ethnic Origin;Evaluation;evidence base;Exhibits;Exposure to;Failure;Family;Family history of;follow-up;Functional disorder;Future;Genetic;Health;Health behavior;High Prevalence;high risk;high risk population;Homeostasis;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Immune system;indexing;Individual;innovation;Interdisciplinary Study;Intervention;Knowledge;Latina;Latino;Latinx;Latinx population;lifetime risk;Link;Literature;Longitudinal cohort;Longitudinal Studies;Los Angeles;Measures;Mentors;Metabolic;Metabolic syndrome;microaggression;middle age;minority children;Nervous System Physiology;Neurosecretory Systems;Non-Insulin-Dependent Diabetes Mellitus;novel;Onset of illness;Pattern;perceived discrimination;Perception;Phenotype;Physical activity;Physiological;Physiology;Policies;Pollution;poor health outcome;Population;post-doctoral training;Predisposition;prevent;Preventive measure;Procedures;programs;psychosocial;Psychosocial Stress;psychosocial stressors;Puberty;public health intervention;Race;racial difference;racial discrimination;racial disparity;racism;Recording of previous events;Research;Risk;Role;Saliva;Schools;Serum;Sleep;Smoking;social;social culture;social determinants;Social Environment;social implication;Social Justice;Social Policies;sociodemographic factors;Stress;stressor;Students;suburb;System;Targeted Research;Testing;Time;tool;Training Programs;Universities;virtual;young adult;Youth

PROJECT_TITLE: Postdoctoral Training Supplement


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Bioengineering;Chronic Pain;Clinical Research;Congenital Structural Anomalies;Osteoarthritis;Pain Research;Pediatric

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative  Developmental dysplasia of the hip dramatically increases the risk for early hip osteoarthritis in adolescents and young adults, and is usually treated surgically with a periacetabular osteotomy. The current project will rigorously investigate how periacetabular osteotomy changes hip biomechanics and how those changes are associated with patients’ activity levels and self-reports of function, pain, and quality of life during the first year after surgery; it will also provide critical training opportunities to a trainee that will promote diversity in health- related research.

PI_NAMEs: HARRIS, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: acetabulum;Adolescent and Young Adult;Bilateral;biomechanical engineering;Biomechanics;career;career development;Caring;Clinical Trials;common treatment;Contralateral;Deformity;Degenerative polyarthritis;Development;Disease;doctoral student;Dysplasia;femur head;Fostering;Geometry;Goals;Growth;Health;Hip Osteoarthritis;Hip region structure;improved;joint biomechanics;Joints;Kinesiology;Mentors;Morphology;muscle strength;Operative Surgical Procedures;Orthopedics;Osteotomy;Outcome Measure;Pain;Parents;Patient Outcomes Assessments;Patient Self-Report;Patients;peer;preservation;Quality of life;Reaction;Research;Research Personnel;response;Risk;Science;Scientist;Shapes;Symptoms;Training;training opportunity;Training Support;Voice;Work

PROJECT_TITLE: Longitudinal Biomechanics and Patient-Reported Outcomes after Periacetabular Osteotomy for Developmental Dysplasia of the Hip

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PI_NAMEs: WYATT, RICHARD THOMAS (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SAN DIEGO

ORG_NAME: GLYCODOTS, LLC

PHR: NARRATIVE Asthma is a debilitating chronic lung disease affecting people of all ages and is the most common chronic disease among children - in the US alone, there are 25 million people living with asthma, of which about 5 million are children. An unmet clinical need exists for rapid diagnostic tools that enable accurate diagnosis, treatment selection, and monitoring of disease activity in asthma patients, thus we propose to develop a low-cost, rapid, and non-invasive diagnostic for asthma from nasal swabs. The impact of this product can revolutionize how people with asthma receive on-the-spot care that is accurate, easy, inexpensive, and personalized.

PI_NAMEs: JACOBSEN, ELIZABETH A;SVAROVSKY, SERGEI A (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Acceleration;accurate diagnosis;Address;Adrenal Cortex Hormones;Affect;Age;Airway Disease;airway inflammation;Antibodies;Arizona;Asthma;asthmatic patient;Binding;Biological Assay;Biological Models;Biological Products;Biopsy;Blood;Buffers;Caring;Cells;Certification;Cessation of life;Chemistry;Child;Chronic Disease;Chronic lung disease;CLIA certified;Clinic;Clinical;Clinical Research;Collection;commercialization;Communities;Complex;cost;cost effective;cost efficient;Cytoplasmic Granules;Detection;detection sensitivity;detection test;Devices;Diagnosis;Diagnostic;Diagnostic tests;diagnostic tool;Disease;Dryness;Economic Burden;Ensure;Enzyme-Linked Immunosorbent Assay;eosinophil;eosinophil peroxidase;eosinophilic asthma;eosinophilic inflammation;Etiology;experience;Failure;Feasibility Studies;Fibrin fragment D;Gelatinase B;Glycosylated hemoglobin A;Goals;health care settings;Health Professional;Human;IgE;Inflammation;Inflammatory;innovation;Laboratories;Lactoferrin;Lateral;Lung;manufacture;Marketing;Measures;Mediating;Methods;Monitor;Monoclonal Antibodies;Morbidity - disease rate;mortality;nasal swab;noninvasive diagnosis;Nose;novel;novel diagnostics;Participant;Patient Monitoring;Patients;Pattern;performance tests;personalized diagnostics;personalized medicine;Persons;Phase;phase 1 study;point of care;point-of-care diagnostics;Point-of-Care Systems;Population;Preparation;Proteins;prototype;Rapid diagnostics;Reader;Reproducibility;Risk;Sampling;Scientist;Selection for Treatments;Severities;Small Business Innovation Research Grant;Spottings;Sputum;Statistical Data Interpretation;Surrogate Markers;Swab;Techniques;Testing;Time;tool;Treatment Protocols;treatment response;Validation;validation studies;Work

PROJECT_TITLE: NOVEL DIAGNOSTIC FOR MANAGING ASTHMA AT POINT OF CARE

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (11)]


NIH_SPENDING_CATS: Asthma;Bioengineering;Chronic Obstructive Pulmonary Disease;Clinical Research;Health Services;Lung;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: Minneapolis

ORG_NAME: KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT

ORG_STATE: MN

PHR: Project Narrative Asthma and COPD are major chronic diseases that affect millions of Americans and presents an enormous burden to the healthcare system. It is well-accepted in the management of asthma that chronic monitoring for worsening inflammation of airways is important. Acute exacerbations of COPD are periodic flares of COPD that lead to worsened quality of life, hastened lung function decline, and higher risk of subsequent cardiovascular events (e.g. stroke, myocardial infarction). A low-cost lung function assessment technology that requires minimal effort to operate properly would fill an unmet need in the management of these diseases.

PI_NAMEs: LICHTER, PATRICK  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute;Address;Adherence;Affect;Air Movements;airway inflammation;Airway Resistance;algorithm development;American;Asthma;base;Biomedical Technology;Blood Vessels;Breathing;Cardiovascular system;Certification;Chronic;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;clinical diagnostics;commercialization;Consult;cost;Data;design;design verification;Development;Devices;Diagnosis;Diagnostic tests;Disease Management;Doctor of Philosophy;Education;Engineering;Ensure;Environment;Evaluation;Event;Exhalation;experience;Face;Flare;Funding;Generations;Grant;graphical user interface;Guidelines;Health;Healthcare Systems;high risk;Home;Human;instrument;Learning;Lung;manufacture;Manufacturer;manufacturing process;Marketing;Measurement;Measures;Medical Device;meter;Monitor;Myocardial Infarction;new technology;Occupational Health;Outpatients;Participant;Patient Care Management;Patient Compliance;Patient Education;Patient Monitoring;Patient Participation;patient screening;Patients;Performance;Periodicals;Phase;Physician Executives;Physicians' Offices;portability;pressure;Principal Investigator;Procedures;product development;Production;programs;pulmonary function;pulmonary function decline;Pulmonary function tests;Quality of life;Readiness;Reproducibility;Research;Resources;respiratory;Respiratory Mechanics;Role;Sales;Science;screening;Seasons;sensor;skills;Software Validation;Spirometry;Stroke;success;System;Tablets;Techniques;Technology;Technology Assessment;Test Result;Testing;trend;Tube;usability;Validation;validation studies;virtual

PROJECT_TITLE: Portable Low-Cost Pulmonary Forced Oscillation Technique Device

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (19)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Sexually Transmitted Infections

ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: This Project Summary/Abstract was originally submitted with R01 AG079193 and is included here unchanged to satisfy submission system requirements. PROJECT NARRATIVE Alzheimer's disease affects 1 in 9 Americans over 65 years of age, is the 6th leading cause of death, and costs $355 billion annually. Herein, we aim to understand how viruses interact with an aging olfactory system to accelerate Alzheimer's disease. This proposal will identify potential biomarkers and therapies (e.g. vaccines and antiviral agents) that may slow or halt progression to clinical dementia, disability, and death.

PI_NAMEs: NAGEL, MARIA ACENA;RESTREPO, DIEGO  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acceleration;Affect;Age Years;Aging;Alzheimer's Disease;American;Amyloid;Amyloid deposition;Anosmia;Anti-viral Agents;Behavioral;Biological;Cause of Death;Cells;Cessation of life;Clinical;comparison control;cost;Coupled;Data;Dementia;dementia risk;disability;Disease;disease phenotype;Disease Progression;entorhinal cortex;familial Alzheimer disease;Frequencies;Genes;Genetic Transcription;Herpesvirus 1;Herpesvirus Type 3;Hippocampus;Human;human old age (65+);Impaired cognition;Individual;Infection;Inflammatory;Liquid substance;Literature;Mus;Nasal cavity;Nerve Degeneration;neuroinflammation;Neuronal Differentiation;Neuronal Dysfunction;olfactory bulb;Olfactory dysfunction;Olfactory Epithelium;Olfactory Pathways;olfactory sensory neurons;Olfactory tract;optogenetics;overexpression;Pathologic Processes;Pathology;Pathway interactions;Peptides;Postbaccalaureate;potential biomarker;prevent;Production;Proteins;Risk Factors;Serum;Smell Perception;System;Testing;treatment risk;Up-Regulation;Vaccines;varicella-zoster virus immediate early protein 62;Viral;Virus;Virus Diseases

PROJECT_TITLE: Postbaccalaureate studies by Ms. Amalia Bustillos understanding whether viral infection of the olfactory system accelerate Alzheimer's disease

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Glaucoma is a leading causes of blindness. Here we will establish a squirrel monkey-induced glaucoma model to study human stem cell-derived RGC cell transplant and integration and potential vision restoration in a retina and visual system closer to those of human. Through validating the monkey glaucoma model and studying key structural and functional measures using innovative new modalities that should be portable between monkey and humans, we will take significant steps towards the goal of vision restoration.

PI_NAMEs: CALKINS, DAVID J.;GOLDBERG, JEFFREY L (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: optic nerve disorder;Retinal Ganglion Cells;System

PROJECT_TITLE: Retinal Ganglion Cell Replacement in Optic Neuropathies


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: PROJECT NARRATIVE INBRE-5 will increase Idaho’s competitiveness in biomedical research and education. The statewide scientific Network will generate, complement, and enrich Idaho’s research capacity by mentoring new investigators, supporting research Cores, fostering regional collaborations, and providing student research opportunities.

PI_NAMEs: BOHACH, CAROLYN HOVDE (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: 3-Dimensional;3D Print;Abbreviations;Academia;Acceleration;Accountability;Address;Adherence;Administrative Supplement;Administrator;Adopted;Advertisements;Advertising;Advisory Committees;Advocate;Affect;Agreement;Agriculture;Air;Air Movements;Alaska;Ally;American;American Association for the Advancement of Science;Amino Acid Sequence;Animal Experimentation;Animal Model;Animals;Annual Reports;anti-cancer research;Appearance;Applications Grants;applied biomedical research;Appointment;Architecture;Archives;Area;Articulation;Artificial Intelligence;ATAC-seq;Attention;authority;Authorship;Award;Awareness;Bachelor's Degree;base;Basic Science;Benchmarking;Big Data;big data management;Binding;Biochemical;Biochemistry;Biohazardous Substance;Bioinformatics;bioinformatics resource;Biological;Biological Process;Biological Sciences;Biology;biomedical data science;Biomedical Engineering;Biomedical Research;Biometry;biosecurity;Biotechnology;bioweapon;birth control;Budgets;building design;built environment;Businesses;Caenorhabditis elegans;Cancer Center;Capital;carbohydrate metabolism;Carbon Dioxide;Cardiac;cardioprotection;career;Career Choice;career development;career preparation;Caring;Catabolism;Cataloging;catalyst;Categories;Cell Culture Techniques;Cell Line;Cell Separation;Cells;Censuses;Center for Translational Science Activities;Centers of Research Excellence;Certification;Cessation of life;Charge;Chemical Weapons;Chemicals;Chemistry;Child;Chromatography;Climacteric;Climate;Clinical;Clinical Research;Clinical Trials;Cloud Computing;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Collaborations;college;Color;commercial application;Committee Members;Common Data Element;Communicable Diseases;Communication;Communities;community college;Community Health Education;Community Networks;community partners;Commuting;Competence;Competitive Bidding;Complement;Complex;Computational Biology;Computational Science;computer center;computer science;computer scientist;Computer software;computerized data processing;Computers;computing resources;Conflict (Psychology);conflict resolution;confocal imaging;Consultations;Contractor;Core Facility;cost;cost estimate;Coupled;Course Content;COVID-19;COVID-19 pandemic;COVID-19 surveillance;Creativeness;Credentialing;Critiques;cultural competence;Curiosities;curriculum enhancement;cyber infrastructure;cyber security;Darkness;Data;data access;data acquisition;Data Adjustments;Data Analyses;Data Collection;data de-identification;data dictionary;data exchange;Data Files;data format;data integration;data management;data preservation;data privacy;data repository;Data Science;Data Science Core;data science education;data science resource;Data Security;Data Set;data sharing;data standards;Data Storage and Retrieval;data visualization;Databases;Dedications;deep learning;Degree Completion;Degree program;demographics;Department chair;Deposition;Descriptor;design;Development;Development Plans;Developmental Biology;Diabetes Mellitus;Diameter;digital;digital object identifier;Dimensions;Disadvantaged;disadvantaged background;Discipline;Discipline of Nursing;Disease;Distance Education;Diverse Workforce;diversity and equity;diversity and inclusion;DNA;DNA sequencing;Doctor of Philosophy;Doctor's Degree;document outlines;Documentation;Drops;Drug Addiction;E-learning;Economics;Education;education pathway;education research;education resources;Educational Activities;educational atmosphere;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;effectiveness evaluation;efficacious intervention;Electricity;Electron Microscopy;Electronic cigarette;Electronics;Elements;Elevator;Eligibility Determination;Employment;Endocrinology;Engineering;Enrollment;Ensure;Entrepreneurship;Environment;Enzymes;Epidemiologic Monitoring;Epithelial Cells;Equilibrium;Equipment;equipment acquisition;Equity;Escherichia coli;Escherichia coli EHEC;Escherichia coli O157:H7;Ethical Issues;Ethics;Evaluation;Event;Exercise;expectation;Expenditure;experience;Experimental Designs;experimental study;Exposure to;Extramural Activities;Face;Facebook;Facility Accesses;Faculty;faculty mentor;Faculty Recruitment;faculty research;faculty support;falls;Familiarity;Family health status;Federal Government;Fee-for-Service Plans;Feedback;Fees;Fellowship;Fellowship Program;Film;First Generation College Students;flexibility;Floor;Flow Cytometry;Focus Groups;follow-up;food science;forging;formative assessment;Fostering;Foundations;frontier;Funding;Funding Opportunities;Future;Gases;Gender;Gene Expression;Gene Expression Profile;Gene Expression Regulation;General Population;Generations;Genes;Genetic;genetic variant;genome resource;Genomics;Geographic Locations;Geography;Gestational Diabetes;Glass;Glucose;Glycogen;Goals;Good Clinical Practice;Government;Graduate Education;graduate school;graduate student;Grant;Grant Review;Grant Review Process;Gravitation;Growth;Guidelines;Hawaii;hazard;Hazardous Substances;Health;Health Care Sector;health disparity;Health Insurance Portability and Accountability Act;Health Sciences;Healthcare;High Performance Computing;high school;High School Student;high standard;higher education;Hispanic;Hispanic Americans;Hispanic Populations;Hispanic-serving Institution;histological image;Home;Hormones;Hospitals;Hour;Housing;Human;human capital;human data;Human Resources;human subject;human subject protection;Human Subject Research;IACUC;Idaho;Illinois;Image;Image Cytometry;imager;Immunization;Immunoglobulin Joining Region;Immunology;Impairment;implantation;improved;Income;Incubators;Individual;Industrialization;Industry;Infertility;Infrastructure;innovation;insight;Institution;Institutional Review Boards;Instruction;instructor;instrument;instrumentation;Insulin;intelligent agent;inter-institutional;interdisciplinary approach;interdisciplinary collaboration;Interdisciplinary Study;interest;International;Internet;Internships;Interview;investigator training;Investments;Ions;Iraq;Ischemia;Island;Job Satisfaction;Kentucky;Kinesiology;Knowledge;knowledge network;Laboratories;Laboratory Animals;laboratory equipment;laboratory experience;Laboratory Research;laptop;large datasets;Latino Population;Laws;Lead;Leadership;Learning;lectures;Letters;Libraries;Life Cycle Stages;Light;Lighting;Link;LinkedIn;Liquid Chromatography;liquid chromatography mass spectrometry;Literature;Litter Size;Livestock;Location;Machine Learning;Mammalian Cell;Mammals;Manuscripts;Maps;Marketing;mass spectrometer;Mass Spectrum Analysis;Master of Science;mathematical sciences;Mathematics;Measurement;Measures;Mechanics;Mediation;Medical;Medical Education;medical schools;medical specialties;Medical Students;meeting abstracts;meetings;member;Memory;Mental Health;Mentors;Meridians;Metabolism;metabolomics;Metadata;Metals;Methodology;Methods;microbial;Microbiology;microCT;Microscope;Mining;Mink;Minority;Mission;Modeling;Modernization;Modification;Molecular;Molecular Analysis;Molecular Biology;Molecular Genetics;Monitor;Montana;mortality disparity;Moscow;Movement;multidisciplinary;multiple data sources;Multivariate Analysis;Mus;Muscle Cells;Names;National Institute of General Medical Sciences;Native American population;Native Americans;natural Blastocyst Implantation;Nevada;New Mexico;new technology;novel;novel strategies;nucleic acid purification;Nucleic Acids;nutrition;Obesity;Occupational activity of managing finances;Occupations;Office Management;online course;open data;open source;operation;Optics;Oral;Oregon;organizational structure;Osmosis;Outcome;Outcome Assessment;Outcome Measure;Outcomes Research;outreach;Ovarian hormone;pandemic disease;pandemic disruption;Paper;Parents;Participant;Pathogenesis;Pathway Analysis;Pattern;peer;peer coaching;Peer Review;Perception;Performance;Periodicals;Personally Identifiable Information;Personnel Management;Persons;petabyte;Phylogenetic Analysis;Physicians;Physics;Pilot Projects;Plant Resins;Plants;Plumbing;Policies;Polishes;Polycystic Ovary Syndrome;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;posters;Poverty;predictive modeling;Pregnancy;Preparation;preservation;pressure;prevent;Primary Care Physician;Principal Investigator;Privacy;privacy protection;Privatization;Prize;probation;Problem Solving;Process;Productivity;profession allied to medicine;professor;Program Development;Program Evaluation;Program Research Project Grants;Program Sustainability;programs;Progress Reports;Prolactin;prospective;protein expression;protein structure;Proteins;Proteomics;Protocols documentation;Pseudonym;Psychology;public database;Publications;Publishing;PubMed;Pyruvate;Qualifying;quality assurance;Questionnaires;Race;Ramp;Reader;Recombinant Proteins;Recommendation;Recording of previous events;Records;Recreation;recruit;Recurrence;Reduce health disparities;Regulation;Rejuvenation;Reperfusion Injury;Reperfusion Therapy;Reporter;Reporting;repository;Reproducibility;Research;Research Activity;Research Design;Research Ethics;research facility;research faculty;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Proposals;research study;Research Subjects;Research Support;Research Training;Resource Allocation;Resource Sharing;Resources;response;responsible research conduct;Review Committee;Review Literature;Rights;Risk;Role;Rotation;Route;Running;Rural;rural underrepresented;rurality;sabbatical;Safety;Sampling;SARS-CoV-2 variant;satisfaction;Schedule;Scholars Program;Schools;Science;science education;Science, Technology, Engineering and Mathematics Education;science, technology, engineering, mathematics, and medicine;Scientific Advances and Accomplishments;Scientist;seal;Seasons;secondary analysis;Secondary Schools;Secure;Security;Selection Criteria;Self Efficacy;Series;Serum;Services;sex;Side;Signal Transduction;simulation;Site;Site Visit;skill acquisition;skills;skills training;Slide;Small Business Innovation Research Grant;Small Business Technology Transfer Research;small molecule;social;Social Distance;Social Network;Social Sciences;socioeconomic disparity;Source;Specialist;Specialized Center;Specific qualifier value;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Speech;Speed;Spiders;square foot;Standardization;statistical learning;statistics;STEM field;STEM research;Step training;Stereotyping;Sterile coverings;Sterilization;Stream;Structure;student mentoring;student participation;Student recruitment;Student Selections;student training;Students;study population;success;sugar;summer research;summer student;supercomputer;Supervision;support network;Surveys;symposium;synergism;System;Talents;Taxonomy;teacher;Teacher Professional Development;teaching laboratory;Teaching Method;Technical Expertise;Techniques;Technology;Technology Transfer;Teleconferences;Testing;Text;Time;Time Management;timeline;tissue culture;Tissue Sample;tool;Training;Training Activity;Training and Education;training opportunity;Training Programs;transcriptome sequencing;transcriptomics;transfer student;Travel;trend;Tribes;Trust;Ultraviolet Rays;Uncertainty;undergraduate education;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;Underserved Population;underserved students;United States Department of Agriculture;United States National Institutes of Health;Universities;University adminstration;university student;Update;urban disparity;usability;Utah;Uterus;vaping;vaping associated lung injury;Vertebral column;Vertebrates;Veterans;Videoconferencing;Vision;Visit;visiting scholar;Visualization;Vocational Guidance;Wages;waiver;Washington;Water;Water Purification;water quality;web page;web site;Wisconsin;Woman;women faculty;Women's Health;Work;Writing;Wyoming;Yersinia pestis;Youth

PROJECT_TITLE: Idaho INBRE Program


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Slowing of walking speed is a major predictor of functional disability, morbidity, and a warning sign for clinical onset of dementia. Walking and cognition are interrelated whereby treating slow walking speed may positively influence cognition. Live Long Walk Strong (LLWS) is a new innovative rehabilitative care that targets slow walking speed. Considering the broad spectrum of mobility and cognitive abilities among aging Veterans, we do not know whether current LLWS treatment is designed optimally to serve individual needs. This study will call attention to rehabilitative treatment adherence, compliance, and responses that need to be addressed based on cognition. The study will provide essential information to develop personalized rehabilitative treatment and advance rehabilitation research.

PI_NAMEs: OGAWA, ELISA  (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Adherence;Age;Aging;Attention;Award;bean;Behavioral;Boston;career;Caring;Cessation of life;Characteristics;Cladribine;Clinical;Clinical Trials;Cognition;Cognitive;cognitive ability;cognitive benefits;Cognitive deficits;Communities;Coupled;Data;Dementia;design;disability;Elderly;Environment;evidence base;Executive Dysfunction;executive function;Exercise Therapy;experience;Foundations;functional decline;functional disability;functional status;Future;Gait;Gait abnormality;Gait speed;Goals;Grant;hands on research;Healthcare Systems;Hospitalization;Impaired cognition;Impairment;improved;improved mobility;Individual;individualized medicine;innovation;insight;K-Series Research Career Programs;Knowledge;Learning;medical schools;Memory;Mentors;Mentorship;Morbidity - disease rate;multidisciplinary;Neurobiology;Neuropsychological Tests;Neuropsychology;New England;novel;older adult;Outcome;Participant;Pathology;Patients;Performance;personalized approach;Phase;Physician Executives;Positioning Attribute;Prevalence;professor;programs;Quasi-experiment;rehabilitation research;rehabilitation science;Rehabilitation therapy;rehabilitative care;Research;Research Design;Research Methodology;Research Project Grants;Research Support;Research Training;response;Role;secondary analysis;Self Efficacy;skills;Time;Training;Training and Education;treatment adherence;treatment optimization;Treatment outcome;treatment response;United States National Institutes of Health;Veterans;Walking;walking speed;Work;Writing

PROJECT_TITLE: The Impact of Cognition on Rehabilitative Treatment for Slow Gait Speed

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Chronic obstructive pulmonary disease (COPD) affects approximately 16% of the Veteran population. COPD is the fourth most prevalent disease in the VA population and one of the most costly to the VA health care system. Over 500,000 service-connected respiratory disabilities have been diagnosed in Veterans and 6.5% of all Gulf War service-connected disabilities are respiratory system related. Other Veterans have experienced acute lung and failure from blast injury or smoke inhalation. Over 2.3 million Veterans reported having some form of “lung trouble” in the 2001 National Survey of Veterans. This project has the potential to revolutionize the rehabilitation of Veterans suffering from lung disease through the development of smart prosthetic lung systems that automatically and rapidly respond to the changing metabolic needs of the patient, thereby increasing patient health, comfort, activity level, and rehabilitation.

PI_NAMEs: POTKAY, JOSEPH ALLEN (contact)

PROJECT_TERMS: Acute;Affect;Age;Air Movements;Alkalosis;American;Anesthesia procedures;Animal Model;Animal Testing;Animals;artificial lung;awake;Blast Injuries;Blood;Carbon Dioxide;Cattle;Cessation of life;Chronic;Chronic Obstructive Pulmonary Disease;comorbidity;Compensation;Computer software;cost;design;Development;Devices;Diagnosis;disability;Disease;Dysbarism;Dyspnea;Electronics;Engineering;Etiology;Excision;Exercise;exhaust;experience;Extracorporeal Circulation;Failure;first-in-human;Flowmeters;Gases;Goals;Gulf War;healing;Health;Healthcare Systems;Hour;Human;Hypocapnia;improved;In Vitro;in vivo;Injury;innovation;laptop;Life;Lung;Lung Diseases;lung injury;Lung Transplantation;Mechanical ventilation;Membrane;Metabolic;Methods;military veteran;Monitor;operation;Patients;Performance;Physical Rehabilitation;Physical therapy;Physiology;Population;Prosthesis;prototype;pulmonary function;Pump;Quality of life;Recording of previous events;Recovery;Rehabilitation therapy;Reporting;Research;respiratory;Respiratory Failure;Respiratory System;Rest;Risk;sensor;Services;sheep model;smoke inhalation;Surveys;System;Technology;technology development;Testing;Time;Transplantation;Ventilator;Veterans;Volutrauma;Waiting Lists;Water;wearable device;Work

PROJECT_TITLE: Automated control of artificial lung systems to meet patient metabolic needs

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Hematology;Microbiome;Nutrition

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative There is a clinical need to support immune recovery in critically ill patients whose bone marrow dysfunction and immune suppression often lead to poor short and long term outcomes. Emerging evidence shows a critical role of the gut microbiome in controlling hematopoiesis and regulating immune function, therefore enteral nutrition can be therapeutically relevant strategy to modulate the microbiome and support immune recovery. Given our previous work utilizing murine models of antibiotic induced bone marrow failure, we hypothesize that plant based enteral nutrition will provide superior recovery from antibiotic-induced bone marrow suppression via microbial fermentation of dietary fiber and production of SCFAs compared to widely adopted artificial enteral nutrition.

PI_NAMEs: CHATRIZEH, MONA  (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Adopted;Anaerobic Bacteria;Anemia;Animals;Antibiotics;Bone Marrow;Bone marrow failure;Bone Marrow Suppression;Cells;Chronic;Clinical;Clinical Trials;clinically relevant;Critical Care;Critical Illness;cytokine;Data;Development;Diet;Dietary Fiber;Disease Progression;dysbiosis;Emergency Situation;Enteral Nutrition;Equilibrium;experimental study;fecal transplantation;Fermentation;Fiber;Functional disorder;functional outcomes;Genomics;Germ-Free;Goals;graduate student;Growth;gut dysbiosis;gut microbiome;gut microbiota;Hematopoiesis;Hematopoietic stem cells;Immune;immune function;immune health;Immune response;Immune system;Immunity;immunoregulation;Immunosuppression;Impairment;improved;improved outcome;Infection;Laboratories;Lead;Learning;Life;Link;Lymphocyte;Lymphocyte Count;Lymphopenia;Lymphopoiesis;Mediating;Mediator;metabolomics;microbial;microbiome;microbiota;mouse model;Mus;Myelogenous;Myelopoiesis;neglect;neutrophil;Neutrophilia;nutrition;Operative Surgical Procedures;Outcome;Patients;Plants;Play;Population;Preparation;Process;Production;protective effect;Publications;Randomized;Recovery;Reproducibility;Research;Risk;Role;Scientist;secondary infection;Series;Shapes;Surgeon;Testing;Therapeutic;therapeutic target;Volatile Fatty Acids;Vulnerable Populations;Work

PROJECT_TITLE: Microbiome targeted nutrition to improve immune function during critical illness


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Suicide;Violence Research;Youth Violence

ORG_CITY: ROCHESTER

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative The alarming rise in youth suicide rates and attempts creates a tremendous public health burden yet, limited knowledge exists regarding the mechanisms associated with youth suicide in high risk groups which is imperative for primary prevention efforts. A parental history of suicidal behavior (SB) is associated with a 4-to- 6-fold increased risk of offspring SB and a younger age of onset for first suicide attempt. The objective of this study is to fill gaps in our current knowledge through examining, longitudinally, how parental history (PH status) is associated with trajectories of neurocognitive functioning (NF) and emotional reactivity/regulation (ERR), how NF and ERR constructs mediate the association between PH status and offspring SB and non-suicidal self-injury (NSSI), and test sex and race as moderators of the association between NF and ERR trajectories and offspring SB/NSSI.

PI_NAMEs: SHEFTALL, ARIELLE HOPE (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Adolescence;Adolescent;Age;age group;Age of Onset;age related;aged;Arousal;Arousal and Regulatory Systems;Attention;Behavioral;Biological;black men;Black race;black women;Cause of Death;Child;Childhood;cognitive control;cognitive system;cohort;computerized;Development;early onset;Emergency department visit;emotion dysregulation;Emotional;Enrollment;experience;externalizing behavior;Family;Feeling suicidal;Female;Functional disorder;Future;Goals;high risk;high risk population;Intervention;Interview;Knowledge;Learning;male;Measures;Mediating;Mediator;Mental Health;Methods;National Institute of Mental Health;Neurocognitive;Neurocognitive Deficit;non-suicidal self injury;offspring;Parents;Participant;Patient Self-Report;peer;Population Heterogeneity;Populations at Risk;Positive Valence;prevent;Prevention;Prevention strategy;Primary Prevention;Public Health;Race;racial disparity;racial population;Recording of previous events;recruit;Regulation;Research;Research Domain Criteria;Research Priority;Rewards;Risk;Risk Factors;Role;Sampling;sex;sex disparity;social communication;Social Processes;Strategic Planning;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide rate;System;Techniques;Testing;transmission process;trend;Visit;Youth

PROJECT_TITLE: Effects of parental history of suicidal behavior on middle/late childhood: Longitudinal assessment of early markers of suicide risk

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BINGHAMTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Project Narrative Cocaine use disorder is a significant health problem, and individual risk for developing this condition is greatly impacted by genetics. The genes that influence cocaine use largely exert this influence through direct and indirect effects on brain function. This project will investigate how genetic risk factors for problematic cocaine use impact dopamine neurotransmission; these discoveries may lead to a better understanding of cocaine use neurobiology and opportunities for improved treatment options.

PI_NAMEs: BAGLEY, JARED R (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: abuse liability;Acute;addiction;Address;Affect;Animals;Autoreceptors;Biology;Brain;Candidate Disease Gene;Chronic;Cocaine;Cocaine Abuse;Cocaine Dependence;cocaine related behaviors;cocaine self-administration;cocaine use;Cocaine use disorder;Complex;Data;Development;Disease;disorder risk;Dopamine;dopaminergic neuron;drug of abuse;Exhibits;Fiber;Genes;Genetic;genetic analysis;genetic approach;Genetic Risk;genetic risk factor;Genetic study;genetic variant;Goals;Health;Heritability;high risk;Human;Hybrids;improved;in vivo;Inbred Mouse;Inbred Strains Mice;Inbreeding;Individual;insight;Intake;Intervention;Intravenous;Kinetics;Knock-out;Knowledge;Measures;Mediator;Methodology;Methods;Modeling;Modernization;Motivation;Mus;neuroadaptation;Neurobiology;neurogenetics;Neurons;Neurosciences;neurotransmission;Nucleus Accumbens;optogenetics;Pathway interactions;Periodicity;Phase;Photometry;Positioning Attribute;prevent;Property;Regulation;Research;response;reuptake;Risk;Risk Factors;risk variant;Scanning;Self Administration;Signal Transduction;skills;Slice;Societies;Techniques;Testing;Training;trait;transmission process

PROJECT_TITLE: Intersecting genetic risk for extreme cocaine self-administration with dopamine neurotransmission


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Our preliminary findings show that RNA abasic sites are abundant, and they stabilize R-loops to regulate the transcription of noncoding RNA. To understand the scope of gene regulation by RNA abasic sites, we will identify their regulatory role genome-wide, identify the enzymes that form RNA abasic sites, and the bases that are removed to form the abasic sites.

PI_NAMEs: CHEUNG, VIVIAN G (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Adenosine;Apolipoprotein E;base;Base Excision Repairs;Binding Proteins;cell type;Cells;Data;DNA;DNA Damage;DNA Polymerase II;DNA Repair;endonuclease;Endonuclease I;Enhancers;Enzymes;Gene Expression;Gene Expression Regulation;Genetic Transcription;genome-wide;hammerhead ribozyme;Hybrids;Length;Mass Spectrum Analysis;Mediating;Methylation;methylpurine;Modification;nucleic acid structure;Nucleic Acids;Pathway interactions;plant poison;prevent;Process;Proteins;Publishing;Reaction;Regulation;Research;response;Ribosomal RNA;Ricin;RNA;RNA Polymerase II;RNA Precursors;Role;Signal Transduction;Site;Stress;Structure;Untranslated RNA

PROJECT_TITLE: Determining the role of RNA abasic sites in gene regulation

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative: α-synuclein membrane interactions play critical roles in neurodegenerative diseases yet remain undruggable. The proposed study seeks to develop a new platform that could accelerate drug discovery on this front.

PI_NAMEs: BAO, HUAN  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Abbreviations;Acceleration;Achievement;Aging;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Amyloid;amyloid peptide;Antibodies;antibody libraries;Binding;Biochemical;Biological Assay;Biology;candidate identification;Cells;Clinical Trials;Color;Consumption;cost effective;Defect;Disease;Disease Progression;disorder control;DNA;drug discovery;Dyes;Economics;effective therapy;efficacy evaluation;Eligibility Determination;Engineering;Engraftment;Financial Hardship;Flow Cytometry;Fluorescence;Fluorescent Probes;Health;high throughput screening;inhibitor;interest;Libraries;Lipid Bilayers;Lipids;Membrane;Methods;Microscopy;Molecular;monomer;mutant;nanobodies;nanodisk;Neurodegenerative Disorders;Parkinson Disease;Persons;Pharmaceutical Preparations;Play;Protein Array;protein misfolding;Proteins;Public Health;rational design;Reagent;reconstitution;Reporting;Role;Scaffolding Protein;screening;sensor;small molecule libraries;social;Societies;Sodium Chloride;Sorting;Source;Specificity;Surface Plasmon Resonance;targeted treatment;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Time;Yeasts

PROJECT_TITLE: A cost-effective, high-throughput screening platform for modulator discovery of a-synuclein membrane interactions involved in neurodegenerative diseases

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Neural activity patterns in the hippocampus are known to support spatial and contextual representations in the brain, critical for episodic memory formation. The goal of this project is to understand how the circuit computations of functionally arranged inhibitory and excitatory hippocampal neurons can support these functions. I will use state-of-the-art single-cell tracing, optogenetics perturbations and imaging to characterize the fine-scale structure of hippocampal networks embedded into local and brain-wide circuits, and their role in coordinating response properties across the neuronal population. This work will be a crucial step towards a better understanding of the physiological basis of memory.

PI_NAMEs: GEILLER, TRISTAN  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Address;Alzheimer's Disease;Anatomy;Animals;Architecture;Area;Autobiography;awake;Award;Behavior;Behavioral;Brain;brain behavior;Brain Diseases;Brain region;Calcium;cell type;Cells;Cognitive;cognitive function;Collection;Computer Models;Data;Development;Dorsal;Electrophysiology (science);Episodic memory;Event;excitatory neuron;experimental analysis;Experimental Designs;experimental study;Functional disorder;Future;Goals;hippocampal pyramidal neuron;Hippocampus;Human;Image;in vivo;Individual;insight;Interneurons;Knowledge;Learning;Life;Maps;Measures;Mediating;medical schools;member;Memory;memory process;Methods;Mind;Modeling;Molecular;Mus;neocortical;neural;neural circuit;Neurodegenerative Disorders;Neurons;neuropathology;Neurosciences;operation;Optical Methods;optogenetics;Output;Pathway interactions;Pattern;Phase;Physiological;Population;postsynaptic neurons;presynaptic;prevent;Process;Property;Pyramidal Cells;rabies viral tracing;receptive field;Recurrence;Research;Research Project Summaries;response;Rest;Role;Shapes;Slice;Specificity;Structure;Supervision;Synapses;System;Testing;Time;Training;two-photon;Universities;Update;Viral;Work

PROJECT_TITLE: Dissecting the functional organization of local hippocampal circuits underlying spatial representations

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Health Services;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Pregnancy;Prevention;Rehabilitation;Serious Mental Illness;Telehealth;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: CENTER MOM, INC.

ORG_STATE: OR

PHR: PROJECT NARRATIVE High rates of depression among pregnant and postpartum people have been recognized as a significant public health problem, particularly among those who are Medicaid-supported and/or Black and/or Indigenous. CenterMom, Inc, has adapted an intervention that is effective in preventing perinatal depression to improve delivery and appeal among Medicaid-supported and/or Black and/or Indigenous pregnant people; end users signal that our product, Center M, will be more satisfactory when perinatal depression screening and intervention home practice delivery is accessible via a smartphone app, thus the proposed research seeks to prototype and test the Center M smartphone app. This work has significant potential to increase the availability of effective perinatal depression prevention strategies among underserved populations and thereby address the NIH missions of supporting child health and well-being, increasing health equity, and preventing maternal morbidity and mortality.

PI_NAMEs: TILDEN, ELLEN LANE (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Address;Advisory Committees;Affect;antenatal;Birth;Black race;care providers;Caring;Cellular Phone;Cessation of life;Charge;Child;child bearing;Child Health;Child Support;Client satisfaction;Clinic;Clinical;Colorado;commercial application;commercialization;community partnership;Computers;cost;Current Procedural Terminology Codes;Data;Deaths of despair;depression prevention;Depression screen;design;digital;digital delivery;digital health;digital solutions;Early Intervention;Educational Curriculum;effective intervention;Effectiveness;efficacy testing;empowerment;evidence base;experience;Family;Fees;flexibility;Focus Groups;Funding;Group Therapy;Health;health equity;Healthcare Systems;high risk;Home;Hospitals;implementation barriers;implementation science;improved;improved outcome;Indigenous;Infant;innovation;Insurance;Intervention;intervention delivery;Knowledge;Licensing;Marketing;Maternal Health;maternal morbidity;Maternal Mortality;Medicaid;Mental Depression;Mental Health;Mental Health Services;mindfulness;mindfulness based cognitive therapy;Mission;mobile application;Modeling;Morbidity - disease rate;mortality;Neonatal;Oregon;Outcome;Overdose;patient engagement;peripartum depression;Personal Satisfaction;Persons;Phase;Pilot Projects;portability;Postpartum Period;preference;Pregnancy;pregnant;Pregnant Women;prenatal;Prenatal care;Prevalence;prevent;Prevention;prevention service;Prevention strategy;Preventive;Primary Prevention;programs;prototype;Psychiatry;Psychology;Public Health;Questionnaires;Randomized;randomized trial;Recommendation;Reporting;Research;Risk Reduction;satisfaction;Science;Signal Transduction;Site;Small Business Technology Transfer Research;smartphone application;Social Workers;Suicide;sustainability framework;System;Tablets;Target Populations;telehealth;Testing;Time;tool;Training;treatment as usual;Underserved Population;United States National Institutes of Health;Universities;usability;Visit;Woman;Work

PROJECT_TITLE: Making Mindfulness-Based Cognitive Therapy accessible for underserved pregnant people: Developing Center M for commercialization


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

PHR: PROJECT NARRATIVE Dysregulation of brain mechanisms that control hedonic function, or `liking' reactions negatively impacts mental health, and may contribute to affective disorders.1,2 Affective neuroscience research has identified brain hedonic hotspots in nucleus accumbens, ventral pallidum, orbitofrontal cortex, and insula that causally amplify hedonic `liking' responses to a sweet taste, but their circuit-level interactions remain poorly understood. The goal of the proposed studies is to verify the existence of a newly discovered hedonic hotspot in anterior cingulate cortex, and to investigate how hedonic hotspots interact by becoming unanimously recruited into action to generate intense `liking' reactions, potentially leading to better therapeutic targets for affective mood disorders, obesity, and eating disorders.

PI_NAMEs: MORALES, ILEANA  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Academic skills;addiction;Administrative Supplement;Affective;affective neuroscience;Anatomy;Anterior;Award;behavior test;Brain;brain circuitry;Calcium;Cannulations;career;Cells;cingulate cortex;Code;Complement;Data Analyses;Development;Eating Disorders;Electrophysiology (science);Event;Fellowship;Fiber;Fostering;Functional disorder;Funding;gamma-Aminobutyric Acid;Genetic;Globus Pallidus;Goals;hedonic;Histology;Hunger;Hypothalamic structure;Image;Immunohistochemistry;in vivo calcium imaging;Incentives;Insula of Reil;integrated circuit;interest;Knowledge;Laboratories;Leadership;Learning;Manuscripts;Maps;Measures;Mediating;Mental Depression;Mental Health;Mentorship;Methods;Microinjections;Molecular;Mood Disorders;Motivation;neural;Neuroanatomy;neurochemistry;neuromechanism;Neurons;neuroregulation;Neurosciences Research;novel;Nucleus Accumbens;Obesity;Opioid;optogenetics;Oral;orofacial;Pathologic;Pattern;Phase;Photometry;pleasure;post-doctoral training;Postdoctoral Fellow;Preparation;prevent;Rattus;Reaction;recruit;Research;response;reward circuitry;Rewards;Role;Satiation;Signal Transduction;Site;skill acquisition;Spottings;Sucrose;sweet taste perception;System;Taste Perception;Technical Expertise;Techniques;Testing;therapeutic target;Training;Work

PROJECT_TITLE: Brain hedonic circuitry mediating 'liking' and 'wanting' for reward (Administrative Supplement/Funded Extension)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cancer;Cancer Genomics;Childhood Leukemia;Down Syndrome;Genetics;Hematology;Human Genome;Intellectual and Developmental Disabilities (IDD);Pediatric;Pediatric Cancer;Rare Diseases

PHR: Project Narrative Approximately 25% of human tumors harbor a gain of the “q” arm of chromosome 1, but the functional consequences of this large-scale dosage change are unknown. We will develop and employ novel computational and genetic strategies to characterize the functional consequences of this alteration. These studies will shed light on the physiological effects of a ubiquitous but poorly-understood feature of tumor genomes.

PI_NAMEs: SHELTZER, JASON  (contact);SUN, RUPING

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Aneuploidy;Applications Grants;Behavior;Biological;Biological Assay;cancer cell;cancer genome;Cell Line;Cells;Child;Chromosome 1;Chromosome 21;chromosome 21 gain;chromosome 21 loss;Chromosome Arm;Chromosomes;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Development;dosage;Down's Syndrome;drug sensitivity;Engineering;Exhibits;fitness;Gene Dosage;Gene Expression;Genes;Genetic;genetic approach;Genomics;Goals;Human;Human Chromosomes;Individual;leukemia;Malignant Neoplasms;Mediating;Methodology;Modeling;novel;overexpression;parent grant;Phenotype;Physiological;programs;Risk;Techniques;tumor

PROJECT_TITLE: Genomic and functional approaches to characterize Chr1q gains in cancer


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Depression;Diabetes;Hypertension;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Neurosciences;Pediatric;Pregnancy;Serious Mental Illness;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This diversity supplement will examine the moderating role of prenatal maternal adversity on the association between gestational diabetes mellitus (GDM) and perinatal maternal depression in a prospective pregnancy cohort at NYU Grossman School of Medicine.

PI_NAMEs: SHUFFREY, LAUREN CHRISTINE (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Adolescent Psychiatry;Affect;Anxiety;Award;Biological Assay;Biomedical Research;Blood;Blood Vessels;Brain;brain volume;career;Catabolism;Child;Child Psychiatry;Chronic;Clinic;Clinical Psychology;Clinical Research;cohort;Communication;Communities;comorbidity;cytokine;Data Analyses;Development;Diagnosis;Discipline of obstetrics;Disproportionately impacts women;Electroencephalography;Environmental Exposure;ethnic minority population;excitotoxicity;experience;Faculty;fetal;Frequencies;Gestational Diabetes;Goals;healthy pregnancy;Hypertension;Individual;Infant;Inflammation;Inflammatory;inflammatory marker;Intercellular adhesion molecule 1;Interferon Type II;Interleukin-1 beta;Interleukin-10;Interleukin-13;Interleukin-2;Interleukin-4;Interleukin-6;Interleukin-8;Interleukins;Intervention;Knowledge;Kynurenine;Magnetic Resonance Imaging;maternal depression;Measures;Mediating;Mediation;medical schools;Mental Depression;Mental Health;Metabolic;Modeling;modifiable risk;Mood Disorders;neurodevelopment;Neurodevelopmental Disorder;neuroprotection;Obesity;offspring;Outcome;Overweight;oxidation;Pathway interactions;pediatric trauma;perceived stress;Perinatal;peripartum depression;Phase;Phenotype;Plasma;Population;Postpartum Depression;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy hypertension;pregnant;prenatal;prepregnancy;programs;prospective;Psychosocial Assessment and Care;racial minority population;recruit;Research;Rest;Risk;Risk Factors;Role;secondary analysis;sex as a biological variable;tenure track;Testing;TNF gene;Training;Tryptophan;Tryptophan 2,3 Dioxygenase;Underrepresented Populations;United States;Vascular Cell Adhesion Molecule-1;vascular injury;Venipunctures;white matter;Woman

PROJECT_TITLE: Gestational Diabetes Mellitus, Perinatal Depression, and Offspring Neurodevelopmental Phenotype - Diversity Supplement


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Sleep Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARATIVE Pediatric sleep problems are a major public health concern and sleep in children with autism spectrum disorders (ASD) is a very high priority for research (see IACC Strategic Plan, Objective 2). Our application, “Sleep, Brain Development, and Behavioral Correlates in a Longitudinal Cohort of Children at High-Risk for ASD,” will leverage a recently funded longitudinal follow-up of 300 7-10 year-old children at high familial risk for ASD (HR; with ASD n~100; without ASD ~200) and 100 low familial risk for ASD (LR) who have had multiple MRI and behavior assessments since infancy through the NIH Autism Center of Excellence Infant Brain Imaging Study (IBIS). Across these three groups (HR-ASD, HR-nonASD, and LR) our aims are to 1) characterize sleep problems in the home using actigraphy, validated by sleep diary, and parent report, (2) examine longitudinal brain trajectories (from infancy) associated with sleep problems in school-age, and (3) examine the relationship of longitudinal behavior trajectories and concurrent behavior to sleep problems in school-age to increase understanding of the neurobiology, developmental characteristics, and co-morbid conditions associated with sleep problems, with implications for developing novel sleep interventions and improving outcomes in this vulnerable population.

PI_NAMEs: ESTES, ANNETTE  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 10 year old;12 year old;Accounting;actigraphy;adverse outcome;Affect;Affective;affective disturbance;Age Months;Anxiety;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic children;Beds;Behavior;Behavior assessment;Behavior Disorders;Behavioral;Biological;biopsychosocial;Brain;Brain imaging;Cerebrospinal Fluid;Characteristics;Child;Childhood;circadian;Circadian Dysregulation;Clinical;Cognition;Cognitive;cohort;Communication;comorbidity;Data;design;Development;developmental disease;Diagnosis;diaries;Disease;early childhood;endophenotype;Environment;executive function;Family history of;follow-up;Follow-Up Studies;Foundations;Funding;Goals;Growth;Health;high risk;Hippocampus;Home;imaging study;improved outcome;improvement on sleep;Individual;infancy;Infant;Intervention;Light;Link;Literature;Longitudinal cohort;Magnetic Resonance Imaging;Maintenance;media use;Medical;Mental disorders;Modeling;Moods;multimodality;Nature;neural;neural correlate;Neurobiology;novel;Outcome;Parents;Pathogenesis;Pattern;Phenotype;Population;Prevalence;Problem behavior;psychiatric comorbidity;Public Health;Reporting;Research;Research Priority;Risk;Sampling;Schedule;School-Age Population;Severities;Siblings;Sleep;Sleep Deprivation;Sleep Disorders;sleep health;sound;Strategic Planning;Structure;Temperature;Testing;United States National Institutes of Health;vigilance;Vulnerable Populations

PROJECT_TITLE: Sleep, Brain Development, and Behavioral Correlates in a Longitudinal Cohort of Children at Risk for ASD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Microbiome;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative As our population ages, the incidence of Alzheimer's disease increases, adding economic and social stress. Here, we seek to dissect how consumption of a sugar-loaded diet alters the microbiome and contributes to the onset and severity of Alzheimer's disease with a long-term goal of using diet as an intervention for Alzheimer's disease.

PI_NAMEs: TISSENBAUM, HEIDI A (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: abeta accumulation;Address;Advanced Glycosylation End Products;Affect;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease patient;American;American diet;Amino Acids;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animal Diseases;Animals;Bacteria;Brain;Buffers;Caenorhabditis elegans;Circulation;constitutive expression;Consumption;Data;Diabetes Mellitus;Diet;dietary;Dietary Sugars;Economics;Environment;Escherichia coli;Food;gastrointestinal system;Genes;Genetic;Glucose;glycation;Goals;Grant;gut microbiota;Health;Health Care Costs;healthspan;Human;Immune;Immune signaling;Incidence;inducible gene expression;Inflammation;insight;Intervention;life span;Link;Lipids;Metabolism;Microbe;microbiome;microbiome alteration;microbiota;Movement;Muscle;mutant;Neurons;Orthologous Gene;Oxidative Stress;Paralysed;Pathogenicity;Pathway interactions;Peptides;Persons;Population;presenilin;Process;promoter;Proteins;Publishing;Regulation;Series;Severities;Signal Pathway;Silver;social stress;Source;Stress;stress management;Structure;sugar;System;Testing;Tissues;tool;Transgenic Animals;Transgenic Organisms;Tsunami

PROJECT_TITLE: Dissecting connections between diet, the microbiome and Alzheimers disease


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The Nursing Science Incubator for SDOH Solutions (N-SISS) at the Johns Hopkins School of Nursing (JHSON) will support nurse scientists and scientists in aligned fields with developing impactful research programs focused on social determinants of health (SDOH) and health equity advancement through a novel course designed to prepare Innovators in the (1) implementation of a new dynamic conceptual approach to SDOH mitigation; (2) application of rigorous SDOH research methods; and (3) effective translation of SDOH knowledge and skills into the development and dissemination of multilevel interventions that advance health equity. To promote scientific workforce development vis-à-vis SDOH mitigation, N-SISS will implement a two- tiered training approach: three annual cohorts of 10 N-SISS Innovators will receive 10 months of in-depth mentoring, conceptual, and methodological training in SDOH and applied research experiences culminating in the submission of an SDOH-focused research (R, K, or F) grant proposal to NIH, while the program materials and events will also be made openly available online to all researchers and students who are interested in becoming ancillary N-SISS network trainees (we estimate at least n=3,600 ancillary network trainees will use the program over the project period). In sum, N-SISS will leverage Johns Hopkins University's extensive research and training infrastructure as well as the program directors' national network of health equity researchers to strengthen the scientific nursing workforce's capacity to conduct impactful, innovative SDOH research to eliminate health inequities and redesign health.

PI_NAMEs: FARLEY, JASON EDWARD;GUILAMO-RAMOS, VINCENT M. (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Address;Applications Grants;Applied Research;Applied Skills;Baltimore;career;career development;cohort;Collaborations;Communication;Communities;cost;Dedications;design;Development;Development Plans;Discipline of Nursing;District of Columbia;Educational Curriculum;Educational Materials;Educational workshop;Enrollment;Environment;Event;experience;Faculty;falls;flexibility;Goals;Health;health equity;health inequalities;health knowledge;health training;human capital;Incubators;Individual;innovation;interdisciplinary collaboration;interest;Intervention;Knowledge;Learning;lectures;Literature;member;Mentors;Methodology;Mission;novel;Nurses;Nursing Research;Participant;peer;peer coaching;Peer Group;Persons;Phase;Play;Policies;Preparation;programs;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Training;residence;Resources;Role;School Nursing;Science;Scientist;self-directed learning;skill acquisition;skills;social capital;Social Development;social health determinants;Strategic Planning;Structure;Students;success;theories;tool;Training;Training and Infrastructure;Training Programs;Translations;United States National Institutes of Health;Universities;web platform;Workforce Development

PROJECT_TITLE: The Johns Hopkins Nursing Science Incubator for SDOH Solutions (N-SISS): Preparing Innovators to Eliminate Health Inequities and Redesign Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-N (06)]


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE Equitable breastfeeding support is crucial, with disparities evident in the decline of breastfeeding rates among minoritized populations beyond birth. Environmental factors and healthcare policies significantly shape outcomes, impacting initiation and duration, especially in Hispanic and Black communities. Virtual lactation support (telelactation) offers a potential solution, but its effectiveness varies across demographics, emphasizing the need for geospatial analysis to comprehensively understand and address disparities in breastfeeding outcomes.

PI_NAMEs: USCHER-PINES, LORI  (contact)

PROGRAM_OFFICER_NAME: LONG, SYLVIA ELISABETH

PROJECT_TERMS: Academy;Address;Affect;Age Months;American;Area;arm;Birth;Black Populations;Black race;Breast Feeding;Breastfed infant;care providers;Caring;Characteristics;Communities;Control Groups;County;Data;Data Analyses;demographics;deprivation;Disparity;disparity reduction;District of Columbia;Effectiveness;Ensure;Environment;Environmental Health;Environmental Risk Factor;Equity;Ethnic Origin;Future;gastrointestinal infection;Geography;Health;Health Policy;Healthcare;Hispanic;Hispanic Populations;Home;Human Milk;Immune system;Improve Access;improved;indexing;Individual;Infant;infant nutrition;innovation;Lactation;Link;longitudinal analysis;Longitudinal Studies;Longitudinal Surveys;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Maternal Health;Measures;Minority;Minority Groups;Monitor;Mothers;Multivariate Analysis;Neighborhoods;Not Hispanic or Latino;obstetric care;Outcome;Ownership;Parents;Participant;Patient Self-Report;Pediatrics;Play;Policies;Population;Postpartum Depression;Postpartum Period;Poverty;Public Health;Puerto Rico;Race;Randomized, Controlled Trials;Recommendation;Resources;Risk;Role;Sampling;secondary analysis;Services;Shapes;social factors;social health determinants;socioeconomics;standard care;Statutes and Laws;structural determinants;Surveys;telelactation;Transportation;treatment arm;treatment group;underserved community;virtual;Visit

PROJECT_TITLE: The Impact of Telelactation Services on Breastfeeding Outcomes among Minority Mothers: Siteless Tele-MILC Trial


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Precision neural circuit editing using engineered electrical synapses We propose to create an approach for directly regulating the transfer of electrical information across neural circuits that encode emotions. After creating this new method for rewiring synapses, we will deploy it in animal models of psychiatric disorders. Thus, our high-risk research has the potential to yield a new therapeutic strategy for treating mental illnesses such as depression, anxiety, and addiction.

PI_NAMEs: DZIRASA, KAFUI  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: addiction;Address;Amygdaloid structure;Animal Model;Anxiety;Behavior;Biological Assay;Brain;brain cell;Calcium;cell type;Cells;conditioned fear;Connexins;designer receptors exclusively activated by designer drugs;Docking;Electrical Engineering;electrical potential;Electrical Synapse;Emotional;emotional behavior;Emotions;Engineering;Evoked Potentials;Exhibits;experimental study;Fluorescence;Fright;Funding;Future;Gap Junctions;Grant;high risk;Individual;Light;Measures;member;Mental Depression;Mental disorders;Methods;model organism;multi-electrode arrays;Mus;mutant;neural circuit;neuroregulation;novel;novel strategies;novel therapeutic intervention;Optics;optogenetics;Physiology;Pre-Clinical Model;prevent;Property;Proteins;Rapid screening;release of sequestered calcium ion into cytoplasm;Research;Rhodopsin;Synapses;System;Testing;tool;Transfection;translation to humans;Viral;Virus

PROJECT_TITLE: Precision editing of neural circuits using engineered electrical synapses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE The proposed Research Evaluating Vagal Excitation and Anatomical Linkages (REVEAL) center aims to conduct groundbreaking research on the effect of vagal nerve stimulation (VNS) on four key autonomic systems: the autonomic nervous system, the cardiovascular system, the immune system, and metabolic system. This research will produce a first-in-the-world dataset that will be foundational for the development of VNS-based therapies for several maladies related to autonomic systems.

PI_NAMEs: EBERLY, LYNN E;IKRAMUDDIN, SAYEED ;LIM, HUBERT HYUNGIL;MACEFIELD, VAUGHAN GARY;NAHAS, ZIAD ;OSBORN, JOHN W (contact)

PROGRAM_OFFICER_NAME: HORGUSLUOGLU, EMRIN U

PROJECT_TERMS: Advocate;Anatomy;Anxiety Disorders;Autonomic nervous system;Cardiovascular system;Clinical;Clinical Data;clinical research site;Clinical Trials Data Monitoring Committees;Data;Data Set;Development;Epilepsy;Gastrointestinal Diseases;Goals;Human;Human Resources;Immune system;Implant;Institution;Medical;Mental Depression;Metabolic;Metabolism;Nerve;novel therapeutics;Organ;Patients;Physiology;programs;Research;response;System;Therapeutic;United States National Institutes of Health;Vagus nerve structure;Work

PROJECT_TITLE: REVEAL - Research Evaluating Vagal Excitation and Anatomical Linkages.


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_DEPT: FAMILY MEDICINE

PHR: PROJECT NARRATIVE - Project 3 This project will use proven effective implementation strategies to build program organizational leadership and program delivery staff implementation capacity to successfully engage urban Native American families in strengths-based, culturally-grounded programs to promote youth physical activity and healthy eating.

PI_NAMEs: ALLEN, MICHELE L (contact);HARDEMAN, RACHEL R;PATTEN, CHRISTI A

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Address;Adoption;after-school program;American Indians;Behavior;Behavioral;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;care systems;Communities;community based participatory approach;community based participatory research;community burden;community clinic;community engagement;Conscious;Consumption;design;Diabetes Mellitus;Diet;Dietary Intervention;Dietary Practices;Disparity;Dose;Education;Educational Curriculum;Effectiveness;effectiveness evaluation;empowerment;ethnic minority;evidence base;Evidence based intervention;Evidence based program;experience;Face;Family;Food;Food Access;food environment;food insecurity;Funding;Future;Goals;Grant;Health;Health behavior;health disparity;health equity;health inequalities;Health Personnel;Healthy Eating;Home visitation;implementation fidelity;implementation intervention;implementation outcomes;implementation process;implementation strategy;improved;Indigenous;innovation;interest;Intervention;Leadership;Maintenance;Measurement;Mentors;Minnesota;Modeling;Native American community;Native American population;Native Americans;nutrition;Obesity;Outcome;parent grant;Parents;Participant;Perception;personalized approach;Physical activity;Primary Care;process evaluation;Program Sustainability;programs;Public Health;Race;racial minority;racism;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Design;Research Personnel;school district;Schools;social;social service provider;socioeconomics;Structure;System;tool;Training;Universities;urban area;urban Native American;urban setting;Voice;Work;Youth

PROJECT_TITLE: Understanding facilitators and barriers for the utilization of an Indigenized meal kit amongst urban Minnesota Native American youth and families


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: CARLSBAD

ORG_NAME: BIOSPYDER TECHNOLOGIES, INC.

PHR: An ongoing Phase II program is focused on validating a gene expression-based assay for accurately classifying patients with Alzheimer’s Disease and other dementias using a sample of blood spotted on filter paper. The blood spotted filter paper samples are easy to collect in the doctor’s office, clinic, or even by self- collection. The program utilizes multiple cohorts of samples, correlates with FDA-approved tests, and aims to elucidate potential novel therapeutic targets. The launch of RUO whole transcriptome tests for Alzheimer’s and pan-dementias will be transformative for the field of neurodegenerative diseases. This impact will be felt across basic research, translational research, and drug discovery and development. Additionally, the subsequent development into a definitive Alzheimer’s or pan-dementia diagnostic assay is anticipated. By enabling self- collection, this test has the potential to reduce health disparities and transform the diagnosis of Alzheimer’s Disease and other dementias. This shift may allow neurologists to focus more on confirmation and treatment rather than diagnostic process. The diversity supplement will focus on Parkinson’s Disease as a component of the pan-dementia test, with the aim to produce a Parkinson’s Disease RUO test and a follow-on diagnostic test.

PI_NAMEs: SELIGMANN, BRUCE E. (contact)

PROGRAM_OFFICER_NAME: RADOJA, NADEZDA

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease test;Amyloid;Basic Science;Biological Assay;Biological Markers;Blood;blood filter;Blood specimen;Breakthrough device;Cells;Cerebrospinal Fluid;Classification;Clinic;cognitive testing;cohort;Collection;companion diagnostics;Dementia;Development;Diagnosis;Diagnostic;diagnostic assay;Diagnostic tests;drug development;drug discovery;FDA approved;Fingers;Future;Gene Expression;Gene Expression Profiling;health disparity;Immune;Immunoassay;in-vitro diagnostics;Marketing;meetings;men;mild cognitive impairment;Neurodegenerative Disorders;Neurologist;new therapeutic target;Paper;Parkinson Disease;Pathway interactions;Patients;Performance;Phase;Positron-Emission Tomography;Process;programs;Reduce health disparities;Risk;sample collection;Sampling;Spottings;Testing;Time;Training;transcriptome;Translational Research;Uncertainty;Whole Blood;Woman

PROJECT_TITLE: Whole blood filter paper assay for Alzheimers Disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Depression;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: MELBOURNE

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: MONASH UNIVERSITY

PHR: PROJECT NARRATIVE Non-suicidal self-injury (NSSI), the deliberate destruction of one’s own body tissue without suicidal intent, usually begins around age 13-14, occurs in around 17% of adolescents living in the community, and is a risk factor for suicide attempts and deaths. The proposed research will analyze structural and functional neuroimaging from the publicly available Adolescent Brain Cognitive Development (ABCD) Study to identify abnormalities of brain networks involved in emotion regulation in youth aged 9-10 who go on to develop NSSI two or more years later. This study will also examine the influence of parental history of depression and school environmental factors that may interact with brain network measures that precede onset of NSSI, in order to improve the understanding of potential mechanisms of vulnerability for NSSI and inform prevention and intervention strategies for NSSI globally.

PI_NAMEs: JENKINS, LISANNE MICHELLE (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Adolescence;Adolescent;Age;Age of Onset;aged;Amygdaloid structure;Back;Behavior;Biological;Brain;brain abnormalities;brain dysfunction;Brain region;Clinical;cognitive control;cognitive development;Communities;comparison control;Complex;Cross-Sectional Studies;Data;Data Set;Development;Diffusion;emotion regulation;Emotional;Emotions;Environmental Risk Factor;Face;Family history of;Feeling suicidal;Female;Functional disorder;Functional Magnetic Resonance Imaging;Future;Image;improved;inclusion criteria;Individual;Informal Social Control;Insula of Reil;Intervention;Investigational Therapies;loved ones;Magnetic Resonance Imaging;male;maternal depression;Measures;Mental Depression;Methods;multimodal neuroimaging;multimodality;neuroimaging;neuroregulation;non-suicidal self injury;novel;parental influence;pharmacologic;Prevalence;prevent;Prevention strategy;protective factors;psychologic;Psychophysiology;Recording of previous events;recruit;Reporting;Research;response;Rest;Risk;Risk Factors;Sample Size;Sampling;school environment;Schools;Sex Differences;Shapes;Signal Transduction;Social Environment;social exclusion;Social Interaction;Structural defect;Structure;suicidal;suicidal morbidity;Suicide attempt;support network;Therapeutic;therapy development;Thick;Thinness;Time;Tissues;white matter;Youth

PROJECT_TITLE: Multimodal Neuroimaging Predictors of Non-Suicidal Self-Injury in the ABCD Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-R(02)M]


ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Depression is a common psychological disorder seen in 18.5% of Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans. Improving the rate of depression recovery and remission is vital to enhance OEF/OIF/OND Veteran’s ability to improve work and home adjustment and overall quality of life. OEF/OIF/OND Veterans have reported many barriers to following through with Cognitive therapy skills practice assignments, a key component of CBT therapy, the leading therapy for depression in the VA. Smartphone apps have been identified as a useful widely-used tool to improve the effectiveness of psychological treatments. We propose a full-scale multi-site randomized clinical trial (RCT) to measure the efficacy of CBT-D enhanced with CBT MobileWork-V, a comprehensive CBT skill training smartphone app (the experimental arm) for improving CBT understanding and skill acquisition and depressive symptoms, in OEF/OIF Veterans with depression compared to standard CBT-D.

PI_NAMEs: CALLAN, JUDITH ANN (contact)

PROJECT_TERMS: Acute;Address;Affect;Aftercare;Anger;Anxiety;Certification;cognitive benefits;Cognitive Therapy;comorbidity;Depressed mood;depressive symptoms;Disease;Disease remission;Effectiveness;Eligibility Determination;empowerment;evidence base;experimental arm;Freedom;Generations;Goals;Health Status;Healthcare;Home;Hospitals;Improve Access;improved;Individual;Information Technology;innovation;Intervention;Life Style;Long-Term Effects;Measures;Mediating;Mental Depression;Mental disorders;Methods;mobile application;operation;Outcome;Paper;Participant;Patients;Personal Satisfaction;Phase;population health;Post-Traumatic Stress Disorders;prevent;Procedures;psychologic;Psychotherapy;Quality of life;Randomized;randomized, clinical trials;Recovery;Reporting;Service delivery model;Site;skill acquisition;skills;skills training;smartphone application;System;Technology;Time;tool;Training;treatment comparison;Veterans;Work

PROJECT_TITLE: Does Adding a Tailored Cognitive Behavioral Therapy (CBT) Mobile Skills App Mediate Higher Rates of Depression Recovery, Adjustment, and Quality of Life in OEF/OIF Veterans Compared to Standard CBT?

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


ORG_CITY: NASHVILLE

ORG_STATE: TN

PHR: Individuals with T2D have increased risk for heart disease, stroke, and death from cardiovascular disease (CVD). The incidence of T2D increases with age, in part due to a decreased ability to expand β-cell mass. Our lab discovered that pharmacological inhibition of the PGE2 receptor, EP3, or activation of the EP4 receptor enhances β-cell proliferation and survival in mouse and human islets. Our preliminary studies in the db/db mouse model of T2D reveal that systemic treatment with EP3 antagonist enhances β-cell proliferation and mass and reverses some of the changes in gene expression associated with β-cell dysfunction. Whole genome sequencing and proteomics will define downstream effects of EP3 and EP4 receptor modulation in β cells of mice and humans with T2D. Unique Vanderbilt resources (de-identified electronic health record and linked DNA samples) will be used to probe PGE2/EP pathway genes in T2D patients and to predict responsiveness to GLP-1 pathway agonists currently used to treat T2D.

PI_NAMEs: GANNON, MAUREEN A (contact)

PROJECT_TERMS: Address;Affect;Affinity;Age;Aging;Agonist;American;antagonist;Anti-Inflammatory Agents;Antioxidants;Beta Cell;Binding;Biological Assay;Cardiovascular Diseases;Cell Death;cell dedifferentiation;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cessation of life;Clinical;clinically relevant;Clone Cells;Compensation;Consensus;Coupled;Couples;Cues;Cyclic AMP-Dependent Protein Kinases;cytokine;cytotoxic;Data;db/db mouse;Diabetes Mellitus;Dinoprostone;DNA;Electronic Health Record;EP4 receptor;Functional disorder;G-Protein-Coupled Receptors;Gene Expression;Genes;genome sequencing;GLP-I receptor;glucagon-like peptide 1;Glycosylated hemoglobin A;Goals;heart disease risk;high throughput screening;Human;Impairment;improved;Incidence;Individual;individual patient;islet;Lead;Ligand Binding;Ligands;Link;Machine Learning;Mitogens;mouse model;Mus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Non-Steroidal Anti-Inflammatory Agents;Obesity;Outcome;pancreatic islet function;Pathway interactions;patient response;Patients;personalized approach;Pharmaceutical Preparations;pharmacologic;Phenotype;Phospholipase C;phosphoproteomics;Play;precision medicine;predicting response;preservation;prevent;programs;Proliferating;Property;Prostaglandin Inhibition;Prostaglandins;Protein Isoforms;Proteomics;receptor;Receptor Activation;receptor expression;Regulation;Regulatory Pathway;Resources;response;RNA Splicing;Role;Sampling;screening;Signal Pathway;Signal Transduction;Sorting;Stroke;Testing;transcription factor;treatment choice;Variant;Veterans;WFDC2 gene;whole genome

PROJECT_TITLE: Modulating prostaglandin E2 receptor activity to improve pancreatic islet function


ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: PROJECT NARRATIVE Women Veterans commonly experience urinary incontinence (UI), a debilitating health problem with a tremendous negative impact on quality of life. Women Veterans may be at increased risk due to exposures during military service, such as restricted toilet access and the impact of heavy protective gear and equipment on the pelvic floor. Behavioral self-management treatments including pelvic floor muscle training, bladder control strategies, and fluid management are widely recommended by guidelines as first-line treatment options because of their demonstrated effectiveness and low risk of side effects. Given the identified need to improve access to UI treatments, we developed and tested two remote delivery models: an interactive mobile-health or mHealth UI smart phone/computer application and clinical video telehealth visits. This proposed study incorporates a sequential, multiple assignment, randomized trial (SMART) design to determine the optimal method for remote delivery of first-line, evidenced-based UI treatments to women Veterans.

PI_NAMEs: MARKLAND, ALAYNE DENISE (contact)

PROJECT_TERMS: active duty;Address;Age;aged;Anxiety;Area;Behavior Therapy;Behavioral;Bladder Control;care systems;Caring;Cellular Phone;Childbirth;Clinical;clinical center;Clinical Trials;compare effectiveness;Computers;Consensus;Data;disability;Discipline;Education;effective therapy;Effectiveness;effectiveness/implementation design;Equipment;evidence base;Evidence based treatment;experience;Exposure to;Funding;Future;Gender;Geriatrics;Goals;Guidelines;Gynecologist;Health;health administration;Health Services Accessibility;Healthcare;implementation science;Improve Access;improved;incontinence symptom;innovation;Intervention;Interview;Life Cycle Stages;Liquid substance;Long-Term Care;Medical;Medical center;Methodology;Methods;mHealth;military service;Mobile Health Application;Modality;Modeling;Mood Disorders;multidisciplinary;Online Systems;Operative Surgical Procedures;Outcome Assessment;Patient Care;Pelvic Floor Muscle;Pelvic floor structure;Perception;Perimenopause;Persons;Physical therapy;Physicians;Positioning Attribute;Post-Traumatic Stress Disorders;practice-based research network;Pregnancy;Prevention Research;Primary Care;primary outcome;Primary Prevention;Provider;Qualitative Methods;Quality of life;Randomized;Recommendation;Rehabilitation therapy;remote delivery;Reporting;Research;Research Priority;response;Risk;Risk Factors;Self Management;Sequential Multiple Assignment Randomized Trial;Severities;sexual assault;side effect;Site;Specialist;Surveys;symptomatic improvement;telehealth;Testing;Training;treatment as usual;trial design;Update;Urinary Incontinence;Urologist;Veterans;virtual healthcare;Visit;Woman;Women's Health;women's treatment

PROJECT_TITLE: Optimizing Remote Access to Urinary Incontinence Treatment for Women Veterans

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Hematology;Infectious Diseases;Prevention;Sepsis

ORG_CITY: Pasadena

ORG_NAME: ACATECHOL, INC.

PHR: Project Narrative/Public Health Statement In the United States each year more than 400,000 Americans undergoing hemodialysis therapy receive placement of a central venous catheter (CVC, or central line), and more than 20% of these suffer from a central line-associated bloodstream infection (CLABSI) with mortality rates estimated at 14-40% as a result. CLABSI pathology is exacerbated by the formation of highly adherent biofilms to the CVC surface. In this SBIR ACatechol proposes to develop a hybrid CVC, providing both antimicrobial efficacy and biofilm repellency simultaneously, to prevent the root cause (i.e., biofilm formation) that current CVCs fail to adequately address.

PI_NAMEs: AHN, KOLLBE  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Adherence;American;Anti-Infective Agents;Antibiotics;antimicrobial;Antimicrobial Resistance;Biocide;Biological Assay;Blood;Catheters;Coagulation Process;Complement Activation;Cyclic GMP;Death Rate;Development;Ensure;Health Care Costs;hemocompatibility;Hemodialysis;Hemolysis;Hybrids;Immobilization;In Vitro;in vivo;infection rate;infection risk;Inflammation;Life;manufacturing facility;Marketing;Microbial Biofilms;microorganism;Outcome;pathogen;Pathology;Patients;Phase;Predisposition;prevent;Prevention;Production;Proliferating;Property;prototype;Public Health;Relative Risks;research clinical testing;Risk;Sepsis;Small Business Innovation Research Grant;Specific qualifier value;Surface;technological innovation;Technology;tool;Toxic effect;Translations;United States;Urinary tract;Venous

PROJECT_TITLE: Hybrid repellant-antimicrobial gemini coatings for prevention of catheter-associated bloodstream infections


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Project Narrative Interest in intestine metabolism grew rapidly when the gluconeogenesis and fructolysis functions of the intestine were identified. Recently developed metabolic therapeutics target these intestine metabolic functions and the locally produced regulatory peptide hormones, but our understanding of their mechanisms of action is incomplete limiting treatment development and application. I aim to measure intestine metabolism of an obesity-associated metabolite family, branched-chain amino acids, regarding other dietary and microbial nutrients to complete our understanding of the involvement of intestine metabolism in whole-body metabolite profiles.

PI_NAMEs: WILLIAMSON, IAN ANDREW (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: absorption;Adipose tissue;Affect;amino acid metabolism;Amino Acids;Animal Model;Animals;Antibiotics;Automobile Driving;Bolus Infusion;Branched-Chain Amino Acids;Cardiometabolic Disease;career;Cell Line;Cells;Communities;Complex;Consumption;defined contribution;detection of nutrient;Diabetes Mellitus;diabetic patient;Diet;diet-induced obesity;dietary;Dietary Proteins;Disease;Distant;Engineering;Ensure;Enteral;Enzymes;Equilibrium;Evaluation;experience;Family;Fasting;Food Interactions;Future;Gastroenterology;Genes;Germ-Free;Gluconeogenesis;Glucose;glucose metabolism;Glutamates;Glutamine;Goals;gut microbiota;Homeostasis;host-microbe interactions;Human;Immunosorbent Techniques;incretin hormone;Ingestion;Insulin Resistance;interest;Intestinal Secretions;Intestines;Intuition;Knowledge;Laboratories;Link;Liver;liver metabolism;Mammals;Measures;Medicine;meetings;member;Mentors;Mentorship;Metabolic;Metabolic Clearance Rate;Metabolic Diseases;Metabolism;metabolomics;Microbe;microbial;microbial products;Microbiology;microbiome;microbiota;microbiota composition;Modeling;Monitor;Mus;Muscle;muscle metabolism;Nitrogen;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Nutrient;nutrient absorption;Nutrient availability;nutrient metabolism;obese patients;Obesity;obesity treatment;Oral;organic acid;Organoids;oxidation;Patients;peptide hormone;Peptides;personalized nutrition;Pharmacologic Substance;Physiology;Pilot Projects;Play;Preparation;Probiotics;Production;programs;Propionates;Proteins;Publications;Research;Resistance;response;Role;Schools;Scientist;screening;Signal Transduction;skills;stable isotope;Sucrose;summer research;synergism;Technical Expertise;Testing;Therapeutic;therapeutic target;therapy development;Tissues;tool;Trace Elements Nutrition;Training;Transgenic Animals;Translations;undergraduate research experience;undergraduate student;Weight Gain;Work

PROJECT_TITLE: Quantifying Enteric Metabolism of Branched-chain Amino Acids in Relation to Other Dietary and Microbiota Nutrients

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE This R25 CARES program addresses gaps in social determinants of health (SDOH) education for nursing researchers, aiming to equip early career scholars, especially those from under-represented backgrounds, with comprehensive SDOH research fundamentals and methodologies. The program includes short courses, summer institutes, mentorship, and networking activities over three years for three cohorts. By fostering a supportive community, enhancing research proficiency, and promoting diversity, the program seeks to empower nurse researchers to conduct impactful SDOH research, contributing to the advancement of knowledge in the field.

PI_NAMEs: CONG, XIAOMEI SOPHIA (contact);NELSON, LARON EARNEST;SARPONG, DANIEL F;VLAHOV, DAVID

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Acceleration;Address;Affect;Age;Applications Grants;Area;career;career development;cohort;Collaborations;Communities;community building;Community Networks;Competence;Complex;curriculum development;design;Development;Discipline;Discipline of Nursing;Economics;Education Projects;education research;Educational Curriculum;Eligibility Determination;empowerment;ethnic minority;Ethnic Origin;Evaluation;Event;Feedback;Fostering;Foundations;fundamental research;Future;hands-on learning;Health;health disparity;health equity;health equity promotion;health inequalities;health outcome disparity;Health Priorities;Hybrids;Individual;innovation;insight;Institution;interest;Intervention;Knowledge;Lateral;Learning;Learning Module;learning progression;learning strategy;lens;Mentors;Mentorship;Methodology;Minority;Modeling;Nurses;Nursing Education;Nursing Research;Outcome;Participant;patient engagement;peer coaching;Peer Review;peer support;Persons;Pilot Projects;Play;Policies;population health;Productivity;programs;Publications;Quality of life;Race;racial minority;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;residence;Residencies;Resource Sharing;Risk;School Nursing;Science;Shapes;simulation;social;social health determinants;Social Network;Social Processes;social skills;Strategic Planning;Structure;summer institute;summer research;symposium;System;Testing;Training;Training Activity;Training and Education;United States National Institutes of Health;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Comprehensive Advancement in Research Education and Training for Social Determinants of Health (CARES)


ORG_DEPT: BIOCHEMISTRY

PHR: Membrane fusion of sperm and eggs is pivotal in sexual reproduction, but its molecular mechanisms are largely unknown. The proposed research will characterize the assembly and architecture of the sperm fertilization membrane proteins, as well as identify and characterize new cell-surface interactions in sperm-egg recognition, adhesion and fusion. Understanding the functional organizations of sperm-egg interactions has direct impact on human fertility and reproductive health.

PI_NAMEs: TANG, SHAOGENG  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Adhesions;Animal Model;antibody engineering;Architecture;Binding;Binding Proteins;Biochemistry;Biological Assay;Biological Process;Biology;Candidate Disease Gene;candidate identification;Cell Adhesion Molecules;Cell fusion;Cell membrane;Cell surface;Cell Surface Proteins;Cell Surface Receptors;Cell-Cell Adhesion;Cells;Cellular biology;Characteristics;Charge;Coiled-Coil Domain;Complementary DNA;Complex;CRISPR-mediated transcriptional activation;Cryoelectron Microscopy;Cultured Cells;design;Diploidy;Disulfides;egg;Electronic Medical Records and Genomics Network;Electrostatics;ERp57;Exhibits;extracellular;Fertility;Fertilization;Fertilization in Vitro;Fluorescence-Activated Cell Sorting;Genetic;Genetic Screening;Genetic screening method;Genetic study;Germ Cells;Haploidy;Human;Immunoglobulins;In Vitro;in vivo;insight;interdisciplinary approach;Laboratories;lens;Libraries;Life;Ligands;Liposomes;male;male fertility;Medicine;Membrane;Membrane Fusion;Membrane Proteins;Methods;Molecular;molecular assembly/self assembly;Molecular Conformation;mouse genetics;Mus;novel;Oocytes;Organism;paralogous gene;Pathway interactions;Phase;Philosophy;Process;professor;programs;Protein Disulfide Isomerase;Protein Engineering;Protein Family;Proteins;Proteomics;receptor;Recombinant Proteins;reconstitution;Regulation;Reproductive Health;Research;Resolution;Role;Sexual Reproduction;sperm cell;Sperm-Ovum Interactions;structural biology;Structure;Sulfhydryl Compounds;Surface;Technology;tenure track;Testing;Training;Universities;Work

PROJECT_TITLE: Cell Surface Receptor Recognition and Membrane Fusion in Mammalian Fertilization


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PI_NAMEs: SUNDQUIST, WESLEY I. (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: AMOT gene;Binding;Biochemical;Biochemistry;Cells;Complex;constriction;Cryoelectron Microscopy;Data;Data Storage and Retrieval;Educational process of instructing;Engineering;Filament;Goals;HIV;HIV Budding;HIV-1;Homo;Human;Impairment;improved;Infection;inhibitor;instrumentation;Length;Membrane;Neck;particle;pathogen;Pathway interactions;Play;Polymers;protein function;Proteins;Series;Site;Structure;Surveys;Tube;Viral;Virion;Virus;Work

PROJECT_TITLE: Biochemistry of HIV-1 Budding