ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE/ LAY SUMMARY The cellular and molecular mechanisms underpinning loss of enteric neurons (ENs) in digestive diseases are still poorly understood, and current therapies to restore and maintain ENs are at best limited. We discovered a population of macrophages (MMs) closely associated with ENs, and the objective of this proposal is to study the distribution of this population in the gastrointestinal tract and its contribution to gastrointestinal physiology. This work has substantial public health relevance since the knowledge acquired from these studies may allow using the novel population of MMs discovered in this application as therapeutic targets for digestive diseases characterized by EN loss.

PI_NAMEs: CIPRIANI, GIANLUCA  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: 3-Dimensional;Adult;Aging;Cells;Central Nervous System;Coculture Techniques;Colon;Communication;Complement;Constipation;CSF1 gene;Data;Development;Digestive System Disorders;Electron Microscopy;Enteral;Enteric Nervous System;Face;gastrointestinal;gastrointestinal function;Gastrointestinal Motility;Gastrointestinal Physiology;Gastrointestinal tract structure;Gene Expression;Genes;Goals;Human;Immune;Immunohistochemistry;Induced Neurons;Knowledge;Knowledge acquisition;Link;Macrophage;Maintenance;Mediating;Microglia;migration;Molecular;Molecular Profiling;monocyte;Motility;mouse model;Mus;Muscle;Nerve;Nerve Fibers;Neuroglia;neuron loss;neuronal survival;Neurons;neurotransmission;novel;novel therapeutic intervention;Patients;Phenotype;Population;Population Distributions;Population Heterogeneity;PTPRC gene;public health relevance;recruit;Regulation;Research;RNA;Role;Signal Pathway;single-cell RNA sequencing;Small intestine muscularis propria;Small Intestines;Sorting;Synapses;synaptogenesis;Testing;therapeutic target;Time;Tissues;Transgenic Mice;Work

PROJECT_TITLE: Role of Muscularis Macrophages in the Enteric Nervous System

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Clinical Research;Diabetes;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative Chronic pancreatitis is a painful and debilitating disease with few medical treatment options. Patients often require pancreatic surgery for relief of pain, but pancreatic surgery may increase the risk for blood glucose abnormalities and diabetes mellitus. At the University of Minnesota, we will enroll patients in multiple clinical research studies in the Chronic Pancreatitis Diabetes Pancreatic Cancer (CPDPC) Consortium and will develop new clinical studies that better define how different pancreatic surgeries impact diabetes risk.

PI_NAMEs: BEILMAN, GREGORY J;BELLIN, MELENA D. (contact);TRIKUDANATHAN, GURU V

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: acute pancreatitis;Address;Adult;Age;Anatomy;Ancillary Study;anti-cancer research;Antibodies;Area Under Curve;Autoantibodies;Autologous Transplantation;Beta Cell;Biological Markers;Blood Glucose;Body mass index;C-Peptide;Caring;Cell Death;Child;chronic pancreatitis;Clinic;Clinical;clinical care;clinical center;Clinical Research;Collaborations;comparison group;Complement;Complex;Control Groups;Cross-Sectional Studies;Data;Defect;design;Development;Diabetes Mellitus;diabetes risk;Disease;DNA;Drainage procedure;Endocrine;Endocrinologist;Enrollment;Environment;Exclusion;Functional disorder;Funding;Future;Gastroenterologist;genetic risk factor;glucagon-like peptide 1;Glucose;Glucose tolerance test;Goals;health related quality of life;high risk;Hormonal;Hormone secretion;Hyperglycemia;Hypoglycemia;illness length;incretin hormone;Infrastructure;innovation;Insulin;insulin secretion;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;interest;Intestines;intravenous glucose tolerance test;islet;Lateral;Lead;Malignant neoplasm of pancreas;Manuscripts;Medical;metabolic phenotype;Minnesota;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;observational cohort study;Ohio;Operative Surgical Procedures;Pain;pain relief;Pancreas;Pancreatectomy;Pancreatic Diseases;Pancreatic Hormones;Pancreatic Polypeptide;Pancreaticoduodenectomy;Pancreaticojejunostomy;Pancreatitis;Participant;participant enrollment;Patient Care;patient subsets;Patients;Physicians;polypeptide;Polypeptide Hormones;prevent;Prevention strategy;primary endpoint;Procedures;protocol development;Protocols documentation;recruit;Regulation;Research;Research Personnel;research study;Resources;response;Risk;Risk Factors;Sampling;Series;sex;Smoking History;Structure;Subgroup;Surgeon;Surgical Management;Testing;Time;Tissues;Total Pancreatectomy;type I and type II diabetes;Universities;working group

PROJECT_TITLE: University of Minnesota Clinical Center for the Study of Pancreatic Disease


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Mortality from chronic liver disease is a pivotal contributor to the recent decline in life expectancy in the US. This project is poised to provide robust new evidence about pathways between social determinants as well as the physical and social environments of communities and fatty liver disease risk and has the potential of elucidating direct areas for policy or clinical intervention. It will also identify underlying structural determinants of excess risk among low SES and ethnic minority populations.

PI_NAMEs: LAZO ELIZONDO, MARIANA  (contact)

PROJECT_TERMS: Address;Affect;Alcohol consumption;Alcoholic Liver Diseases;Area;Behavior;Behavioral;Black Populations;burden of illness;Characteristics;Chinese;Chronic;Chronic Disease;chronic liver disease;Clinical;Cohort Studies;Communities;community-level factor;contextual factors;Country;COVID-19 pandemic;Data;Development;Diabetes Mellitus;Diet;disease disparity;Disease Outcome;disorder risk;Disparity;Enzymes;Epidemic;Epidemiology;ethnic disparity;ethnic minority;ethnic minority population;Event;Fatty acid glycerol esters;fatty liver disease;follow-up;Funding;gene environment interaction;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic variant;Geography;Health;health care availability;Hispanic;Image;Incidence;Individual;Inflammation;Intervention;Investigation;Latino;Life Expectancy;Literature;Liver;Liver diseases;liver inflammation;longitudinal analysis;Longitudinal Studies;low socioeconomic status;Measures;Mediating;men;Minority Groups;mortality;Multi-Ethnic Study of Atherosclerosis;multi-racial;Myocardial Ischemia;Neighborhoods;non-alcoholic fatty liver disease;novel;Obesity;Obesity Epidemic;Outcome;Participant;Pathway interactions;Pattern;Persons;Physical environment;Policies;population based;population health;Preventive;Preventive service;prospective;Proxy;psychosocial;Psychosocial Factor;psychosocial stressors;Public Health;racial disparity;Racial injustice;racial minority;Research;Research Personnel;Risk;Risk Behaviors;Role;Sampling;Scanning;screening;Serum;social;social determinants;social disparities;Social Environment;social health determinants;socioeconomic disparity;Socioeconomic Status;socioeconomics;Stroke;structural determinants;success;Testing;Therapeutic;United States National Institutes of Health;Viral hepatitis;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Social determinants of fatty liver disease and its racial/ethnic disparities: The Multi-Ethnic Study of Atherosclerosis

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Public Health Relevance Statement/ Narrative The recent emergence of SARS-CoV-2 has created a public health emergency, making it challenging to keep schools open for in-person learning. This proposal will assess the trade-offs associated with different policies to keep schools open and kids in the classroom with the potential for increased transmission, by integrating school-level infection monitoring data with community-level testing data, vaccination data, and immunological and serological indicators among students and faculty. Model simulations will be used to identify cost-effective strategies, while accounting for community concerns for optimal sentinel surveillance, with an aim to minimize student infection risk while maximizing time in school.

PI_NAMEs: DEFELICE, NICHOLAS B (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Adult;Applications Grants;Award;Biological Sciences;built environment;career;Child;Child Development;Chronic;cognitive development;Communicable Diseases;Communities;community based participatory research;community engagement;Community Health;community transmission;coronavirus disease;cost;cost effective;COVID-19;COVID-19 mortality;COVID-19 pandemic;Data;design;Development;Disease;disease transmission;Education;emerging pathogen;Engineering;epidemiological model;Epidemiology;experience;Faculty;Fostering;Foundations;Future;future pandemic;Goals;Government;Health;Immune;Immune response;Immune system;Immunity;Immunologics;Immunology;improved;Infection;Infection Control;infection rate;infection risk;infectious disease model;insight;Instruction;Intervention;Knowledge;Learning;life span;Mathematics;Measures;Mentors;Mentorship;model building;Modeling;models and simulation;Monitor;New York City;novel;Outcome;pandemic preparedness;Pediatric epidemiology;Persons;Play;Policies;Population;Positioning Attribute;Preparation;pressure;Prevalence;prevent;programs;Property;Public Health;public health emergency;public health relevance;Public Policy;Quarantine;Reading;Recording of previous events;repository;Research;Research Activity;Respiratory Disease;Risk;risk mitigation;Role;SARS-CoV-2 transmission;school closure;school environment;Schools;Scientist;Sentinel;Sentinel Surveillance;Serology;severe COVID-19;Shamanism;skills;Social Development;Students;success;support tools;surveillance data;Testing;Time;Training;Training Activity;Translating;transmission process;trigger point;Uncertainty;United States;Vaccination;Vaccines;Variant;Viral;virology;Virus;virus host interaction;Wages;Work

PROJECT_TITLE: Pandemic preparedness in schools: A community based approach for sentinel surveillance

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Overall The research workforce in areas of Kidney, Urology and Hematology (KUH) needs to be strengthened in order to address pressing scientific questions and find treatments for patients affected by KUH conditions. The current proposal will create an innovative training program that will bring together pre- and postdoctoral trainees across 6 academic institutions across Chicago who will learn together about cross-cutting tools in a way that will allow them to develop a common language, apply the tools into their own research, and form sustained interdisciplinary research interests and collaborations. The results will have important implications for the KUH scientific community and for clinical care of patients with KUH conditions.

PI_NAMEs: KLUMPP, DAVID J;LASH, JAMES P.;QUAGGIN, SUSAN E. (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Address;Affect;Agreement;Area;Award;career;career development;Chicago;Cities;clinical care;Clinical Trials;Collaborations;collaborative environment;college;Committee Members;Communities;Complex;cost;design;Development;Dimensions;Ecosystem;Educational workshop;Entrepreneurship;Evaluation;Evidence based intervention;Focus Groups;Funding;Future;Goals;Grant;Health;Hematological Disease;Hematology;high school;Human Resources;Illinois;improved;Individual;innovation;Institution;Interdisciplinary Study;interest;Investments;Journals;Kidney;Language;Leadership;Learning;Location;Medical Students;meetings;member;Mentors;Metabolism;Mission;Modification;National Institute of Diabetes and Digestive and Kidney Diseases;nephrogenesis;next generation;novel strategies;outreach program;Patient Care;Patients;Pediatric Hospitals;peer;peer coaching;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Prevalence;prevent;Process;Program Evaluation;programs;Research;Research Personnel;Research Priority;Research Support;Research Training;Resource Development;Resources;response;Science;Scientific Advances and Accomplishments;Scientist;Secure;Services;skills;societal costs;Talents;technological innovation;Therapeutic;Time;TNFSF15 gene;tool;Training;Training Programs;trend;United States;Universities;Urology;Vision;Work

PROJECT_TITLE: Chicago Kidney Urology Hematology network FOR city-Wide reseArch tRaining and career Development (Chicago KUH FORWARD)


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Clinical Research;Diabetes;Digestive Diseases;Health Services;Pancreatic Cancer;Primary Health Care;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE This proposal aims to recruit a large and ethnically diverse population of subjects from Texas and Louisiana for the ongoing studies of the consortium (CPDPC) to study Chronic Pancreatitis (CP), Diabetes (DM) and Pancreatic Cancer (PDAC) launched by the collaborative efforts of NIDDK and NCI. To effectively contribute to the ongoing CPDPC clinical studies, we have assembled a team of researchers and clinicians (gastroenterologists, endocrinologists and internists) from tertiary and primary care centers to effectively accomplish the goals of the CPDPC. Additionally, we propose six innovative ancillary study concepts that will deepen our understanding of the connection between DM, PDAC and CP and facilitate the identification of subjects with PDAC among subjects with new onset DM.

PI_NAMEs: CHARI, SURESH T. (contact);MAITRA, ANIRBAN

PROJECT_TERMS: Abbreviations;Accident and Emergency department;African American population;Algorithms;Ancillary Study;Biological;Cancer Center;chronic pain;chronic pancreatitis;Clinic;Clinical;Clinical Data;Clinical Research;Clinics and Hospitals;cohort;Cohort Studies;Collaborations;Community Healthcare;Consent;Data Coordinating Center;data management;data warehouse;design;Diabetes Mellitus;Diagnosis;Diagnostic;electronic medical record system;Endocrinologist;Epidemiology;epidemiology study;ethnic diversity;Evaluation;Exocrine pancreatic insufficiency;experience;falls;Familiarity;Functional disorder;Gastroenterologist;Gastroenterology;Goals;Health Sciences;Health system;Healthcare;Healthcare Systems;hospital care;Hospitals;Hyperglycemia;Incidence;Information Technology;Infrastructure;innovation;Inpatients;insight;Institution;inter-institutional;Internist;Link;Location;Longitudinal cohort study;Louisiana;Malignant neoplasm of pancreas;Minority Groups;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Outpatients;Pancreatic Ductal Adenocarcinoma;Pancreatitis;Pathogenesis;Pathology;patient population;Patient Recruitments;Patients;Performance;Play;Population;Population Heterogeneity;Positioning Attribute;Primary Care;primary care patient;Primary Care Physician;Primary Health Care;Principal Investigator;Procedures;prospective;Prospective cohort;Prospective Studies;Race;Records;recruit;Research Personnel;research study;Research Subjects;Resources;Retrospective Studies;Role;Running;Secondary to;Seminal;Series;Site;Specific qualifier value;success;System;tertiary care;Testing;Texas;Therapeutic;translational study;Underrepresented Minority;Universities;working group

PROJECT_TITLE: The Texas-Louisiana Alliance to Study Chronic Pancreatitis, Diabetes and Pancreatic Cancer


NIH_SPENDING_CATS: Hematology;Kidney Disease

PI_NAMEs: GEORGE, ALFRED L. (contact)

PROJECT_TERMS: Adult;Area;Award;Basic Science;Benign;career;career development;Chicago;Child health care;Childhood;Cities;Clinical and Translational Science Awards;Clinical Sciences;Collaborations;collaborative environment;Communication;Communities;Data;Dedications;Development;Discipline;Education;Education and Outreach;Educational process of instructing;Effectiveness;Ensure;Environment;Equity;Evaluation;Evaluation Reports;Event;experience;Feedback;formative assessment;Fostering;Funding;Future;Goals;Hematology;higher education;Illinois;improved;Individual;Institution;inter-institutional;Interdisciplinary Study;Kidney;Kidney Diseases;Leadership;Learning;Medical;Medical center;medical schools;meetings;Mentors;Mission;Monitor;Morphologic artifacts;Multiple Partners;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Outcome;Pediatric Hospitals;Performance;Persons;Physicians;Postdoctoral Fellow;pre-doctoral;Privatization;Process;Program Evaluation;programs;Recommendation;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Science;Scientist;Structure;success;System;TNFSF15 gene;Training;training opportunity;Training Programs;Translational Research;undergraduate research;Universities;Urology;virtual;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative – Neuroimmunology Training Program at the University of California, Irvine The Neuroimmunology Training Program (NITP) at the University of California, Irvine will train the next generation of interdisciplinary scientists at the research nexus of the central nervous system (CNS) and immune system in order to accelerate the treatment of human neurological diseases. Meeting the challenge of maintaining CNS function throughout life, as well as developing therapies to combat prevalent neurodegenerative and neurologic disorders, requires an understanding of neuroimmune interactions and neuroinflammatory responses on a molecular and cellular level. The bi‐directional communication of molecules between the CNS and the immune system are required for proper development, organization, and maintenance of a healthy CNS with optimal function and disruption or inappropriate balance of these essential neuroimmune can exacerbate and even cause neurologic disorders and pathology.

PI_NAMEs: GREEN, KIM ;LANE, THOMAS E (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS


PI_NAMEs: MARTIN, ALINE C (contact)

PROJECT_TERMS: Academy;Acceleration;Active Learning;Address;Adopted;Adult;apprenticeship;Area;career;career development;Career Exploration;career life balance;Career Mobility;Chicago;Cities;Clinical and Translational Science Awards;Collaborations;Communication;Competence;Complement;Dedications;Development;Development Plans;Discipline;diversity and inclusion;Education;educational atmosphere;Educational Curriculum;Educational process of instructing;Educational workshop;Ensure;Entrepreneurship;Evaluation;expectation;experience;Exposure to;Faculty;faculty mentor;Foundational Skills;Funding;Goals;graduate school;graduate student;Grant;hands on research;Hematology;Human Resources;improved;Individual;Institution;Journals;Kidney;Knowledge;leadership development;Learning;Maps;Mentors;Mentorship;minority trainee;Mission;Modeling;National Institute of General Medical Sciences;oral communication;peer;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Program Development;programs;recruit;Research;research data dissemination;Research Methodology;Research Personnel;Research Training;Resource Development;Resources;satisfaction;Science;Science, Technology, Engineering and Mathematics Education;Self Assessment;Self Efficacy;skills;stress management;success;Teacher Professional Development;technological innovation;Technology Transfer;theories;Time Management;tool;Training;Training Programs;Underrepresented Minority;United States National Institutes of Health;Urology;Vision;Writing

PROJECT_TITLE: Professional Development Core


NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Teenage Pregnancy;Vaccine Related

ORG_CITY: SAN CLEMENTE

ORG_NAME: CENTER FOR INNOVATIVE PUBLIC HEALTH RESEARCH

PHR: PROJECT NARRATIVE Findings from this study will provide a comprehensive view directly from adolescents about how the COVID-19 pandemic is impacting their sexual health both in the short- and long-term. Results will inform where and how health supports and sexual health interventions aimed at alleviating the impacts of COVID-19 can be targeted, particularly those that address adolescent sexual health disparities.

PI_NAMEs: NELSON, KIMBERLY M;YBARRA, MICHELE L. (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: 17 year old;Address;Adolescent;Adolescent Behavior;adolescent health;adolescent sexual behavior;adolescent sexual health;Adult;Affect;Anal Sex;Area;Behavioral;Birth;Characteristics;condoms;Contraceptive Agents;Contraceptive methods;COVID-19;COVID-19 impact;COVID-19 pandemic;Data;Decision Making;design;Development;Ecology;Ensure;ethnic identity;ethnic minority;ethnic minority population;experience;Family;Frequencies;Future;Gender;Gender Identity;Health;Health behavior;health disparity;health inequalities;Health Policy;Health Resources;Health Services;Herd Immunity;HIV;Individual;interest;Learning;Life;longitudinal analysis;Longitudinal cohort;Longitudinal trends;Maintenance;marginalization;marginalized community;Measures;Mental Health;minority children;Modeling;Outcome;pandemic disease;penis;Persons;Phase;Policies;Population;population health;pre-exposure prophylaxis;Pregnancy Rate;Public Health;Race;racial minority;racial minority population;recruit;Reduce health disparities;Reporting;Research;Safe Sex;school closure;sex assigned;Sex Behavior;Sexual and Gender Minorities;Sexual Health;sexual health intervention;sexual identity;Sexually Transmitted Diseases;Social Distance;social media;stay-at-home order;Subgroup;substance use;Surveys;Testing;Time;trend;unintended pregnancy;United States;Unsafe Sex;uptake;Vaccination;vaccine distribution;Vaccines;Vagina;Youth

PROJECT_TITLE: Adolescent health behaviors in the time of COVID-19

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Diabetes;Hematology;Nutrition;Stroke

ORG_CITY: LEXINGTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative  Type 1 diabetes mellitus (T1DM), a condition of high blood glucose, greatly increases the risk of heart attacks and strokes; yet how T1DM exacerbates heart attacks and strokes is unclear. This proposal looks into how high blood glucose alters glucose-related metabolic pathways in platelets, making them more prone to activation and blood clot formation. The knowledge gained from our studies will facilitate development of new therapeutic strategies to reduce the risk of heart attacks and strokes in diabetic patients.

PI_NAMEs: WANG, QINGJUN  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acute;Address;Affect;Animal Model;Arterial Injury;Binding;Biological Assay;Biology;Blood coagulation;Blood Glucose;Blood Platelets;Blood Vessels;Buffers;Calcium;Carbon;Cardiovascular system;Cause of Death;Chelating Agents;chelation;Citric Acid Cycle;Clot retraction;Coagulation Process;Consumption;Data;Development;Diabetes Mellitus;diabetic patient;Doctor of Philosophy;Enzymes;Event;Fibrin;first responder;Fructose;Genetic;Gluconeogenesis;Glucose;glucose metabolism;Glucose Transporter;glucose uptake;Glucosephosphate Dehydrogenase;glycemic control;Glycogen;glycogen metabolism;Glycogen Phosphorylase;Glycolysis;Heart Diseases;Hemostatic function;Homeostasis;Human;Hyperactivity;Hyperglycemia;Impairment;In Vitro;in vivo;Incidence;inhibitor;inorganic phosphate;Insulin-Dependent Diabetes Mellitus;Kentucky;Kinetics;Knowledge;Lead;Learning;Literature;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Middle Cerebral Artery Occlusion;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;NADP;new therapeutic target;novel;novel therapeutic intervention;Obstruction;Operative Surgical Procedures;Outcome;Oxidation-Reduction;Pathogenicity;Pathway interactions;Patients;Pentosephosphate Pathway;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylases;Platelet Activation;platelet function;Positioning Attribute;Production;Protein Dephosphorylation;Pulmonary Embolism;Reactive Oxygen Species;Reduced Glutathione;Regulation;Reporting;Rest;Risk;Risk Reduction;Rodent;Role;Source;stable isotope;Streptozocin;Stroke;stroke risk;Testing;Thrombin;Thrombosis;thrombotic;Thrombus;tool;Universities

PROJECT_TITLE: Platelet Metabolism in Diabetes Mellitus

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Hematology;Kidney Disease

PI_NAMEs: SCHNAPER, H WILLIAM (contact)

PROJECT_TERMS: Active Listening;Address;apprenticeship;Attitude;Awareness;career;career development;Career Exploration;Career Mobility;Chicago;Cities;Collaborations;college;Communities;Complement;design;Destinations;Development;Disease;Ecosystem;Education;Educational workshop;Electronics;Ensure;Environment;Evaluation;Event;experience;Face;Faculty;Focus Groups;Fostering;Generations;Goals;graduate student;Growth and Development function;Health;Hematology;high school;Illinois;Individual;innovation;Institution;interest;Joints;Journals;Kidney;Knowledge;leadership development;Learning;Link;Maintenance;manufacture;medical schools;Medical Students;Mentors;Mentorship;Methodology;Mission;Modeling;next generation;outreach;outreach program;Participant;Pediatric Hospitals;peer;peer coaching;Postdoctoral Fellow;pre-doctoral;Privatization;Problem Solving;Recording of previous events;recruit;Research;Research Personnel;Research Training;Resources;Role;role model;Science;skills;social;Social Interaction;social media;success;Talents;Teacher Professional Development;tool;Training;Underrepresented Minority;Universities;university student;Update;Urology;Vision;Vocational Guidance;web portal;Woman

PROJECT_TITLE: Networking Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Diabetes;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative. The Consortium for the Study of Pancreatitis: Pittsburgh Clinical Center (PCC) is a clinical-translational program at the University of Pittsburgh and UPMC designed to conduct studies related to chronic pancreatitis, diabetes and pancreatic cancer. As a member of the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC), the PCC will participate in collaborative studies planned by the consortium. The track record of accomplishments of the PCC in the CPDPC as well as leadership and contributions to other collaborative networks will ensure continued success and effectiveness of the CPDPC.

PI_NAMEs: BRAND, RANDALL ;YADAV, DHIRAJ  (contact)

PROJECT_TERMS: acute pancreatitis;Address;Ancillary Study;Animal Model;Area;authority;biobank;Bioinformatics;Biological;Biological Markers;biomarker identification;biomarker signature;Biometry;Categories;chronic pancreatitis;Classification;Clinical;clinical center;clinical infrastructure;clinical practice;Clinical Research;clinical translation;Clinical Trials;cohort;Collaborations;Data;data exchange;data management;Data Reporting;design;Development;Diabetes Mellitus;Diagnosis;Disease;Disease Progression;disorder subtype;Effectiveness;Eligibility Determination;Endocrinology;Enrollment;Ensure;Enzyme-Linked Immunosorbent Assay;Epidemiology;experience;Extramural Activities;Faculty;follow-up;Funding;Future;Genes;Genetic;Genotype;Goals;high risk;Image;Individual;Inflammatory;Infrastructure;instrument;Knowledge;Lead;Leadership;life span;Malignant neoplasm of pancreas;Measures;member;Modeling;Morbidity - disease rate;Multicenter Studies;multidisciplinary;Mutate;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Nursing Faculty;organizational structure;Pain;Pancreas;Pancreatic Diseases;Pancreatic Ductal Adenocarcinoma;Pancreatitis;Participant;participant enrollment;Pathogenesis;Patients;Phenotype;Physiology;predictive modeling;prevent;Prognosis;prognostication;programs;Publications;Publishing;Quality of life;randomized, clinical trials;Recurrence;Research;research faculty;Research Infrastructure;Research Personnel;Resources;Risk;Sampling;Screening for cancer;Site;SNP array;Structure;success;targeted sequencing;Teacher Professional Development;Therapeutic;tool;translational study;Universities;Urine;Work;working group

PROJECT_TITLE: Consortium for the study of chronic pancreatitis, diabetes and pancreatic cancer: Pittsburgh Clinical Center


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: DURHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Therapy-resistant prostate cancer is a lethal disease with no curative options available. We have found a tumor- promoting gene can express multiple gene products responsible for the therapy resistance of prostate cancers, and a drug blocking these gene products can effectively kill the cancer cells. Successful completion of this project will lead to the discovery of a new therapeutic option for prostate cancer patients. Page ‐1‐

PI_NAMEs: DONG, XUESEN ;HUANG, JIAOTI  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Adenocarcinoma;Adenocarcinoma Cell;Affinity Chromatography;Alternative Splicing;androgen independent prostate cancer;Androgen Receptor;anti-cancer;ascorbate;Biological Assay;cancer cell;Cancer Cell Growth;Cancer Patient;cancer stem cell;Cell Proliferation;Cell Survival;Cells;chemotherapy;Clinical;clinically relevant;cohort;Combined Modality Therapy;Complex;Degradation Pathway;Development;Disease;Epigenetic Process;Exons;Focal Adhesion Kinase 1;gene product;Generations;Genes;genome-wide;Genomics;Goals;Growth;Histology;Hypoxia;Immunohistochemistry;improved;In Situ Hybridization;insight;Invaded;kinase inhibitor;Knowledge;Label;Malignant neoplasm of prostate;Mass Spectrum Analysis;Mediating;Molecular;nanopore;Neoplasm Metastasis;neoplastic cell;Nerve Block;neural;Neuroendocrine Carcinoma;neuroendocrine differentiation;Neuroendocrine Prostate Cancer;Neurosecretory Systems;novel therapeutics;Oncogenes;Oncogenic;Outcome;Oxidative Stress;Palliative Care;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Peroxidases;Pharmaceutical Preparations;Phase I/II Clinical Trial;phosphoproteomics;Phosphotransferases;programs;Prostate Adenocarcinoma;prostate cancer cell;prostate cancer progression;Prostatic Neoplasms;Protein Biosynthesis;protein degradation;protein expression;Protein Kinase;Proteomics;Reagent;Receptor Signaling;Reporting;Resistance;RNA;RNA Splicing;Role;Sampling;Signal Transduction;Spliced Genes;Stress;Subgroup;targeted treatment;Techniques;Technology;Testing;Therapeutic;therapy development;therapy resistant;transcription factor;transcriptome;transcriptome sequencing;tumor;tumor growth;Tumor Promotion;Variant;Xenograft procedure

PROJECT_TITLE: The role of focal adhesion kinase in therapy resistant prostate tumors


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE In the past decade, dramatic advancements in high throughput singe-cell genomics and multiomics have enhanced our ability to study heterogeneous cell populations, making it possible to study cell states that make up complex tissues and organs, and to better understand cellular transitions that happen during temporal processes such as differentiation and disease development. Most recently, we have gained the ability to concurrently measure multiple modalities from the same single cell - including the transcriptome, the methylome, the epigenome, and the proteome -; however, interpretable computational models to characterize and annotate cells subjected to multiomic measurement are lacking. Here, we propose to develop interpretable machine learning models to enable integrated analysis of multiomic single-cell data to enable deep and comprehensive characterization of heterogeneous cell populations at multiple scales.

PI_NAMEs: YARDIMCI, GALIP GURKAN (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Binding;Biological Assay;Cell Differentiation process;Cells;Chromatin;Complex;computational suite;Computer Models;Computing Methodologies;Data;Detection;Development;Disease;Disease Outcome;epigenome;epigenomics;explainable machine learning;Genomics;Heterogeneity;Individual;insight;Link;machine learning model;Measurement;Measures;Methodology;Methods;methylome;Modality;Modeling;multimodality;Multiomic Data;multiple omics;novel;Organ;Population;Process;protein biomarkers;Proteome;Research Personnel;Resolution;success;Surface;Technology;Time;Tissues;transcription factor;transcriptome;transcriptomics;Variant

PROJECT_TITLE: Integrative characterization of cell state via modeling of multi-omics data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Human Genome;Mental Health;Neurodegenerative;Neurosciences;Precision Medicine;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: EDINBURGH

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF EDINBURGH

ORG_ZIPCODE: EH8 9NY

PHR: PROJECT NARRATIVE This project will add important large-scale blood proteomic data (~7000 proteins) to the already very well- characterized Lothian Birth Cohort 1936 (LBC1936) for which considerable longitudinal cognitive and brain imaging data have already been collected. It will be the first major endeavor to identify novel blood proteomic biomarkers for the critical changes in cognitive function and brain structure that occur during early phases of disease progression prior to clinical ADRD diagnosis. The data generated will have the potential to contribute to precision medicine and will increase our knowledge of the broad spectrum of biological pathways and networks, beyond the amyloid/tau pathways, that are involved at the very earliest stages of AD.

PI_NAMEs: HARRIS, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: abeta accumulation;Acute;Age;age related cognitive change;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Biochemistry;Biological;Biological Assay;Biological Markers;Birth;Blood;blood-based biomarker;Brain;Brain imaging;brain magnetic resonance imaging;brain tissue;cerebral atrophy;Clinical;Cognitive;Cognitive aging;Cognitive deficits;cognitive function;cohort;Computerized Medical Record;cost effective;Data;data acquisition;data harmonization;Data Set;Databases;Dementia;Diagnosis;Disease Progression;DNA Methylation;druggable target;Ensure;Epigenetic Process;epigenomics;Exhibits;Female;Functional disorder;Funding;Future;gene interaction;Generations;genomic data;Genomics;Glial Fibrillary Acidic Protein;Goals;Growth;hazard;human old age (65+);Impaired cognition;indexing;Inflammatory;Knowledge;Lead;lifestyle data;Longitudinal cohort;Longitudinal Studies;Maps;Measures;Mendelian randomization;metabolomics;Methods;Methylation;mild cognitive impairment;minimally invasive;Modeling;Molecular;multiple omics;Neurocognitive Deficit;Neurofibrillary Tangles;neuroimaging;neurotoxic;novel;Participant;Pathway interactions;Pharmaceutical Preparations;Phase;Phenotype;Plasma;pre-clinical;precision medicine;Process;Prospective Studies;protein biomarkers;Proteins;Proteomics;Proxy;Recontacts;recruit;Research;Sample Size;Sampling;Scotland;Secure;Senile Plaques;sex;Sex Differences;Specimen;Structure;success;tau aggregation;tau Proteins;Testing;therapeutic target;Time;uptake

PROJECT_TITLE: Longitudinal multi-omic biomarkers for neurocognitive decline prior to dementia onset

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: Project Narrative: Research at Makerere University in Uganda has in the past led to successfully translated global health breakthroughs. In response to the increasing number of grants and the increasing need for fair international research collaboration and capacity building of research administrators, the work in this application will result into the development of a local institutional framework to strengthen NIH grants administrative practices by providing senior and Junior researcher administrators with advanced training and exposure to pre and post award best grants management practices and standard operating procedures. The development process for this framework will position Makerere University as an institutional model for Research administration and management in a low resource setting.

PI_NAMEs: TAYEBWA, MORDECAI  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Address;Administrator;Africa;Africa South of the Sahara;African;Award;Biomedical Research;burden of illness;Cementation;Chicago;Collaborations;college;Communicable Diseases;Continuing Education;Country;Development;Disparity population;Emergency response;Ensure;Environment;experience;Exposure to;Face;Faculty;Funding;Funding Agency;Future;global health;Goals;Grant;Growth;Health;Health Sciences;improved;Infectious Diseases Research;Infrastructure;Institution;institutional capacity;International;Knowledge;Lead;Learning;low and middle-income countries;Mentors;Modeling;Morbidity - disease rate;mortality;Occupational activity of managing finances;peer;Policies;Positioning Attribute;Practice Management;Procedures;Process;programs;rapid growth;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Training;Resource-limited setting;response;Standardization;Structure;System;Testing;Time;Training;Translating;Uganda;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Expanded Strengthening of Makerere University's Research Administration Capacity Program (E-SMAC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 NKD-D (J2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative The proposed study aligns closely with several strategies under Goal 2 of the National Plan to Address Alzheimer’s Disease. Knowledge gained from this work can be used to help “optimize care quality and efficiency” for persons with ADRD. By producing knowledge that will inform nursing home structure planning and policy decisions, we hope to strengthen the capacity of nursing homes to deliver care which “maintains the dignity, safety, and rights of people with ADRD”.

PI_NAMEs: RAHMAN, MD MOMOTAZUR (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Acute;acute care;Address;Administrator;Adopted;Advance Care Planning;adverse outcome;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Area;Authorization documentation;beneficiary;care coordination;care fragmentation;care outcomes;Caregivers;Caring;Characteristics;Chronic;Chronic Disease;Clinical;Comprehensive Health Care;Contracts;COVID-19;COVID-19 pandemic;Data;Dementia;dementia care;design;Development;econometrics;Effectiveness;Electronic Health Record;end of life;end of life care;end of life outcomes;Enrollment;Evaluation;experience;Family;Fee-for-Service Plans;Goals;Growth;Healthcare;Home Nursing Care;Hospitalization;improved;Incentives;Individual;insight;Institution;Interview;Knowledge;Lead;Long-Term Care;Long-Term Care for Elderly;Longitudinal cohort;Managed Care;Marketing;Measures;Medicaid services;Medical;Medicare;Medicare claim;Medicare Part A;Medicare/Medicaid;Methods;model design;Modeling;Modernization;novel;nursing care quality;nursing home length of stay;Nursing Homes;Nursing Staff;older adult;Outcome;pandemic disease;Patient-Focused Outcomes;payment;Performance;Persons;Policies;Portraits;post-pandemic;pre-pandemic;Primary Care;Process;Provider;Quality of Care;Quasi-experiment;Registered nurse;residence;Retrospective cohort;Rights;Safety;satisfaction;Savings;Selection Bias;Site;Source;Special needs plan;Structure;Testing;Time;United States Centers for Medicare and Medicaid Services;Vulnerable Populations;Work

PROJECT_TITLE: Assessing the Effects of Institutional Special Need Plan (I-SNP) Enrollment on Quality of Long-Term and End-of-Life care for Elderly Individuals with Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-P (91)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Brain Disorders;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Neurosciences;Rare Diseases;Women's Health Research

ORG_CITY: STILLWATER

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: Project Narrative/Relevance Human alphaherpesvirus 1 (HSV-1) infection causes cold sores, genital lesions, encephalitis and serious ocular disease. Unfortunately, antiviral drugs are not always effective. Exciting new studies revealed HSV-1 latently infected female mice exhibit enhanced neuroinflammation and senescence in brainstems of latently infected female mice. The proposed research will identify cellular genes that mediate sex-specific neuroinflammation and senescence in brainstem of mice.

PI_NAMEs: JONES, CLINTON J (contact);SUBRAMANIAN, MADHAN

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acceleration;acute infection;Adrenal Cortex Hormones;Adrenal Glands;Adult;Age;Aging;Anti-viral Agents;Apoptosis;Astrocytes;Basal Ganglia;biological adaptation to stress;Brain;Brain Stem;Cell Cycle Arrest;Cell Death;cell injury;Cells;Central Nervous System;chemokine;Code;Complex;congenital infection;Conscious;cost;Cultured Cells;Cyclin-Dependent Kinase Inhibitor 2A;cytokine;Cytoplasmic Granules;Death Rate;design;Dexamethasone;differential expression;disease transmission;Early Promoters;Encephalitis;Esthesia;Exhibits;Eye diseases;Face;Female;Gene Expression;gene product;Genes;Genitalia;Glucocorticoid Receptor;Grant;Herpes Labialis;high reward;high risk;Human;human pathogen;Hydrocortisone;Impairment;Infection;Inflammation;Inflammatory;inflammatory marker;insight;Jaw;latency associated transcript;Lesion;Link;locus ceruleus structure;male;marenostrin;Mediating;Mediator;Melanins;Mission;Modeling;Motor Neurons;Mus;mutant;nano-string;Necrosis;Nerve Degeneration;Nervous System;neuroinflammation;neuronal survival;Neurons;Neuropathogenesis;Norepinephrine;novel;novel therapeutic intervention;novel virus;Oryctolagus cuniculus;Process;Production;Productivity;Proprioception;Proteins;Publishing;reactivation from latency;recombinant virus;Recurrent disease;Research;response;RNA;senescence;senescence associated secretory phenotype;senescent cell;Sensory;sex;Sex Differences;Simplexvirus;Site;SLC43A1 gene;Spinal;Stimulus;Stress;stressor;Structure of trigeminal ganglion;Structure of trigeminal nerve spinal tract nucleus;Synapses;Technology;Testing;Touch sensation;transcription factor;Trigeminal System;Viral;Viral Encephalitis;Viral Genes;viral transmission;Virus;Virus Diseases;virus host interaction;Virus Replication;virus testing

PROJECT_TITLE: HSV-1 preferentially induces neuroinflammation and senescence in female mice.

STUDY_SECTION: VDT

STUDY_SECTION_NAME: Viral Dynamics and Transmission Study Section [VDT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Cocaine use disorder (CUD) is highly debilitating and common, but without established treatments. Individuals with CUD show elevated activity to cocaine cues in a key region in the reward network, the ventral striatum (VS), which is positively associated with the extent of cocaine craving, making the VS an ideal neural target for neuromodulation interventions for CUD. We propose a proof-of-concept study showing feasibility of using a novel neuromodulation intervention, transcranial focused ultrasound (tFUS), to target the VS in 25 healthy volunteers (in the UG3 phase), using a reward task that reliably activates the VS to reward; and then (in the UH3 phase) perform a sham-controlled trial to determine the effects of targeting the VS with tFUS on neural responses to cocaine cues and cocaine craving in 40 individuals with CUD, as a promising way forward to develop new device- based interventions for CUD.

PI_NAMEs: FERRARELLI, FABIO ;MOUSSAWI, KHALED ;PHILLIPS, MARY LOUISE (contact)

PROGRAM_OFFICER_NAME: REICHEL, CARMELA MARIE

PROJECT_TERMS: Adverse effects;Affect;aged;Anterior;Behavioral;Cephalic;Chronic;Cocaine;cocaine craving;cocaine cue;cocaine use;Cocaine use disorder;Corpus striatum structure;craving;Cues;Decision Making;Development;Devices;Disease;disorder risk;Dorsal;Focused Ultrasound;Focused Ultrasound Therapy;follow-up;Functional Magnetic Resonance Imaging;Globus Pallidus;Goals;Handedness;Health;healthy volunteer;Hour;Impulsivity;Individual;Institutional Review Boards;Insula of Reil;Intervention;Measures;Mental disorders;Methodology;Monitor;Moods;Nervous System Disorder;neural;neural network;Neuronavigation;neuroregulation;novel;Pain;Participant;Patients;Pattern;Persons;Phase;Positioning Attribute;preference;Prefrontal Cortex;Protocols documentation;psychosocial;Reporting;response;Rest;Rewards;sex;simulation;Structure;substance use;Substance Use Disorder;support network;Techniques;Thalamic structure;trait;transcranial direct current stimulation;Transcranial magnetic stimulation;Treatment Protocols;Universities;Ventral Striatum

PROJECT_TITLE: Modulating ventral striatal activity and connectivity with transcranial focused ultrasound as a putative novel intervention for cocaine use disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 JRB-M (J2)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

PHR: PROJECT NARRATIVE Interpersonal dysfunction is a major contributor to the immense personal and societal cost of depression, undermining patients’ capacity for employment, independent living, and maintaining meaningful relationships. The goal of the proposed project is to identify the biobehavioral mechanisms of co-rumination (an established marker of interpersonal dysfunction in depression characterized by excessively discussing personal problems and dwelling on negative affect), by testing the role of (a) linguistic and neural synchrony between dyadic partners using simultaneous dual-subject EEG recordings and (b) mobile sensing of naturalistic communication on the smartphone. This innovative, multimethod project will identify precise linguistic patterns and brain circuits linked to depression risk at the dyadic level, which can be targeted in future interventions to improve functional outcomes.

PI_NAMEs: LI, LILIAN Y.  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Address;Adolescent;Adult;Behavior;biobehavior;Biological;Brain;career development;Cellular Phone;Child;Chronic;Cognition;Communication;computer science;computerized tools;Couples;Data;depressive symptoms;Development;Development Plans;Diagnostic;Distress;Electroencephalography;Emotions;Employment;experience;Feeling;Female;Frequencies;Friends;Friendships;Functional disorder;functional improvement;Future;Goals;Hydrocortisone;Independent Living;Individual;individual variation;innovation;interdisciplinary collaboration;Intervention;Knowledge;Laboratories;Language;Lead;Linguistics;Link;Literature;Major Depressive Disorder;male;Measures;Mediating;member;Mental Depression;Mentorship;Methodology;Methods;mobile sensing;Modeling;Moods;Motivation;National Institute of Mental Health;Natural Language Processing;negative affect;neural;neurophysiology;Neurosciences;novel;Onset of illness;Outcome;Parents;Pathway interactions;Patient Self-Report;Patients;Pattern;Personal Communication;Phase;Physiological;Play;Process;prospective;Psychopathology;recruit;Refractory;Research;Research Domain Criteria;Research Methodology;Research Personnel;respiratory;Risk;Risk Factors;Role;rumination;Running;Same-sex;Severities;sex;Sinus Arrhythmia;social;societal costs;System;Testing;Text Messaging;Time;Training;Universities;Work

PROJECT_TITLE: Linguistic and Neural Synchrony During Co-Rumination as Interpersonal Mechanisms of Depression in Adult and Adolescent Dyads

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-M (02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: In preclinical therapeutic studies, the ability to conduct high-throughput imaging of large quantities of mice is crucial. While bioluminescence imaging has been widely utilized in cancer drug discovery and offers high- throughput capabilities, it is not readily applicable to Alzheimer's disease (AD) research. However, chemiluminescence imaging, similar to bioluminescence imaging, possesses desirable features such as high signal-to-noise ratios (SNRs), cost-effectiveness, and the potential for high-throughput imaging. In this proposal, we hypothesize that the chemiluminescence probe ADLumin-X can be effectively employed to monitor the therapeutic effects of AD drugs using a high-throughput approach in AD mouse models. By leveraging the advantageous properties of chemiluminescence imaging, we aim to facilitate an efficient and comprehensive evaluation of the efficacy of AD therapeutics in a large number of mice. By employing ADLumin-X as a tool for high-throughput chemiluminescence imaging, we anticipate significant advancements in our ability to monitor and assess the therapeutic responses of AD mice. This approach can potentially enhance the efficiency and effectiveness of AD drug discovery and evaluation processes, ultimately leading to improved treatments for AD.

PI_NAMEs: RAN, CHONGZHAO  (contact);ZHANG, CAN MARTIN

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: 3-Dimensional;Acceleration;AD transgenic mice;Address;Advanced Development;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease therapeutic;Amaze;Amyloid beta-Protein;Animal Model;anti-cancer research;Antibodies;Antineoplastic Agents;bioluminescence imaging;Brain;Brain imaging;Clinical;Clinical Trials;cost effective;cost effectiveness;Data;Dependence;Deposition;design;design verification;Disease;drug development;drug discovery;Drug Evaluation;Drug usage;Dwarfism;Effectiveness;efficacy evaluation;enzyme activity;Exhibits;Fees;Fluorescence;fluorescence imaging;Future;Goals;histological image;Image;imaging modality;imaging probe;improved;In Vitro;in vivo;in vivo imaging;in vivo two-photon imaging;Inflammation;Injectable;Label;Language;Malignant Neoplasms;Molecular;Monitor;mouse model;Mus;Noise;novel;optical imaging;Optics;Penetration;Pharmaceutical Preparations;Positron-Emission Tomography;pre-clinical;preclinical imaging;Process;Property;Reactive Oxygen Species;Reporting;Research;Rotation;Signal Transduction;System;Therapeutic Effect;Therapeutic Intervention;Therapeutic Studies;Tissues;tool;Transgenic Organisms;treatment response;two-photon;Validation;water solubility;Wild Type Mouse

PROJECT_TITLE: Molecular Chemiluminescence Probes for Imaging of Amyloid beta in Animal Models

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Behavioral and Social Science;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE States are adopting policy reforms for school resource officer programs to promote school safety, youth development, and mental health. The proposed project will analyze state SRO policies and examine their impacts on school-level exclusionary discipline and arrests, including racial and ethnic inequities in these outcomes. The project will also investigate whether and how state SRO policy reforms are implemented in school districts with and without school-wide positive behavioral interventions and supports systems to inform the development of a state SRO law implementation toolkit that promotes positive behavioral support for students.

PI_NAMEs: HULLENAAR, KEITH  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;adolescent health;adolescent mental health;Adopted;Adverse effects;Area;Award;Behavior;Behavior Therapy;Behavioral;Child Health;Color;Communities;Community Actions;community based participatory research;community intervention;Complex;Congresses;Crime;Criminal Justice;Criminology;cultural competence;design;Development;disability;Discipline;Education;educational atmosphere;Educational process of instructing;Effectiveness;Emotional;ethnic disparity;Evaluation;Exposure to;feasibility testing;Goals;Health;high school;Iatrogenesis;implementation facilitators;implementation science;improved;Inequity;Injury;Intervention;Interview;Law Enforcement;Law Enforcement Officers;Laws;Link;longitudinal database;marginalized population;Medicine;Mental Health;Mentorship;Methodology;mortality;National Institute of Child Health and Human Development;Outcome;Pathway interactions;Police;Police officer;Policies;Policy Analysis;prevent;Prevention;Prevention strategy;Program Evaluation;programs;Protocols documentation;Psychiatry;Public Health;Qualitative Research;racial disparity;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;response;Role;Safety;Sampling;school district;school shooting;school violence;school violence prevention;Schools;Security;skills;social;socioeconomics;Structure;Students;success;Support System;Surveillance Methods;Surveys;System;Testing;theories;Training;transition to adulthood;United States;Variant;violence prevention;Work;Youth;youth violence prevention

PROJECT_TITLE: Examining the Implementation and Impact of School Resource Officer Policy Reform in the United States


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Microbiome;Neurodegenerative;Neurosciences

ORG_CITY: GREAT FALLS

ORG_NAME: MC LAUGHLIN RESEARCH INSTITUTE

ORG_STATE: MT

PHR: Project Narrative Individuals with two copies of the APOE4 gene are 12 times more likely to develop Alzheimer’s disease compared to those with two copies of the APOE3 version of the gene, yet how different APOE gene alleles mediate Alzheimer’s risk is unclear. Studies suggest that different APOE genotypes result in altered inflammatory responses, which may lead to neuroinflammation, neural damage, and cognitive decline in individuals with APOE4. In this study, we will test the theory that neutrophils, an inflammatory cell type that can damage tissue, play a role in neuroinflammation in individuals with APOE4, and determine if and how neutrophils could be targeted in individuals with APOE4 who have Alzheimer’s disease or are at risk for Alzheimer’s disease.

PI_NAMEs: HENSLEY-MCBAIN, TIFFANY  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Age;Age Years;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-3;Apoptosis;Automobile Driving;Bacteria;Behavior assessment;behavioral outcome;Body System;Brain;brain based;brain parenchyma;cell type;Cerebrovascular system;Chronic;Coculture Techniques;commensal bacteria;cytokine;Data;Disease Progression;dysbiosis;Encephalitis;experimental study;extend lifespan;extracellular;gastrointestinal;Gastrointestinal tract structure;Genes;genetic risk factor;Genotype;Goals;Histologic;Human;Immune system;Impaired cognition;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;innovation;Intraperitoneal Injections;Late Onset Alzheimer Disease;LDL-Receptor Related Protein 1;Leukocytes;life span;Ligands;Mediating;Mediator;Memory Loss;microbial;microbiome;microbiome alteration;microorganism interaction;Modeling;mouse model;Mus;neural;Neurofibrillary Tangles;Neuroglia;neuroinflammation;neutrophil;Neutrophil Activation;Neutrophil Infiltration;Pathogenesis;Peripheral;Phagocytes;Play;promoter;Publishing;response;Risk;Role;Senile Plaques;Shotgun Sequencing;Signal Transduction;Stimulus;stool sample;System;targeted treatment;Testing;theories;therapeutic target;Tissues;Work

PROJECT_TITLE: Investigating neutrophilic inflammation as an APOE genotype-specific mediator of neuroinflammation and cognitive decline in aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative The proposed research is relevant to public health because it aims to identify novel digital markers to detect subtle cognitive decline in the preclinical phase of Alzheimer’s disease and related dementias (ADRD) and that can be used to evaluate outcomes of early interventions aimed at mitigating advanced cognitive decline. The proposed research is relevant to NIH’s mission as it contributes to fundamental knowledge to protect health. It also aligns well with the NIA’s Strategic Directions for Research on Aging goals of understanding the dynamics of the aging process, including the prognosis of disease.

PI_NAMEs: ORAVECZ, ZITA  (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Address;Adult;Age;Aging;aging process;Alzheimer disease detection;Alzheimer's disease related dementia;Bayesian Analysis;Bayesian Method;Bayesian Modeling;Binding;Biological Markers;Blood;causal variant;Cellular Phone;Characteristics;Clinical;Clinical Trials;Code;Cognitive;Cognitive aging;cognitive change;cognitive performance;cognitive process;cognitive task;cognitive testing;Communication;Computer Models;computerized data processing;computerized tools;Data;Data Collection;Data Set;Decision Making;dementia risk;design;Detection;Diffusion;digital;Digital biomarker;disease prognosis;Disease Progression;Early Diagnosis;Early Intervention;Face;forgetting;Frequencies;Genetic Risk;Goals;Health protection;Impaired cognition;Individual;Individual Differences;information processing;Inherited;innovation;interest;Intervention;Knowledge;Learning;Life;Link;Long-Term Effects;Longitudinal Studies;Maps;Measurement;Methodology;middle age;Mission;Modeling;Modernization;Monitor;Nerve Degeneration;Neurodegenerative Disorders;normal aging;novel;Outcome;Pattern;Performance;Persons;Phase;Phenotype;pre-clinical;predictive marker;Probability;Procedures;Process;processing speed;Prospective Studies;Public Health;Publishing;Research;Research Design;Research Personnel;Risk;Sampling;Short-Term Memory;Signal Transduction;Task Performances;Testing;Time;time interval;time use;tool;United States National Institutes of Health;Visual;Visuospatial;Work

PROJECT_TITLE: Multi-timescale process models to disentangle subtle cognitive decline and learning effects

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Pediatric;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Nashville

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Early onset cocaine use during critical neurodevelopmental periods like adolescence is associated with pronounced cognitive deficits later in life which are paralleled by neurobiological changes in the prefrontal cortex (PFC). Therefore, we propose a series of studies aimed at testing the hypothesis that physiological and cognitive deficits associated with adolescent cocaine exposure are mediated by the mGlu1 subtype of metabotropic glutamate (mGlu) receptor on specific neuron populations in the PFC. Results from these studies will enhance our understanding of the neurobiology underlying neurodevelopmental consequences related to early onset cocaine exposure and will aid in efforts to develop mGlu receptor modulators as novel medications to treat cocaine use disorder.

PI_NAMEs: LUESSEN, DEBORAH JOYCE (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Adherence;Adolescence;Adolescent;Adult;associated symptom;Behavioral;Brain region;career;cell type;Cells;Cocaine;Cocaine Dependence;cocaine exposure;cocaine use;Cocaine use disorder;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive performance;cognitive process;cognitive testing;Communication;critical period;Data;drug abuse vulnerability;Drug Exposure;early onset;efficacy evaluation;Electrophysiology (science);Fiber;flexibility;Foundations;Functional disorder;Goals;GRM1 gene;Image;Impaired cognition;Impairment;improved;in vivo;Individual;insight;interest;Interneuron function;Interneurons;Life;Mediating;Mentors;Metabotropic Glutamate Receptors;Mus;Neurobehavioral Manifestations;Neurobiology;neurodevelopment;Neurons;novel;novel therapeutic intervention;Output;patch clamp;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Photometry;Physiological;Population;positive allosteric modulator;Prefrontal Cortex;receptor;Regulation;Reporter Genes;Research;Risk;Rodent Model;Role;Series;Short-Term Memory;Somatostatin;stimulant exposure;Stimulus;Substance Use Disorder;Synapses;Techniques;Testing;Therapeutic;therapeutic target;Time;tool;touchscreen;Training;Transgenic Mice;Transgenic Organisms;transmission process

PROJECT_TITLE: Mechanisms of mGlu1 regulation of cortical inhibition and cognitive function: Implications in adolescent cocaine exposure

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: TROY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

PHR: Project Narrative Polymorphism in the APOE gene is the leading risk modulator for late onset Alzheimer’s Disease (LOAD) but the molecular mechanisms by which Apolipoprotein E (ApoE) influences AD risk remain poorly understood. We will study the differential binding modes between ApoE isoforms and heparan sulfate (HS) using a multi-scale, multi-disciplinary approach, which we hypothesize to play an important role in modulating AD risk. Successful completion of this project will provide novel insights into how ApoE isoforms contribute to AD risk through their distinct interactions with HS, and will identify new drug targets for AD.

PI_NAMEs: LIU, JIAN ;WANG, CHUNYU  (contact);WANG, LIANCHUN

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Affect;Affinity;Age;Alleles;Alzheimer's Disease;Animal Model;Apolipoprotein E;apolipoprotein E-4;Binding;Binding Sites;Brain;brain control;brain tissue;Cell Line;Cell model;Cell surface;Charge;Data;Dementia;Dependence;Epitopes;Genes;genetic manipulation;Genetic Polymorphism;genetic risk factor;genome wide association study;Genotype;Heparin;Heparitin Sulfate;insight;interdisciplinary approach;Kinetics;Knock-out;knockout gene;Late Onset Alzheimer Disease;Link;Liquid Chromatography;Maps;Measures;Methods;Modification;Molecular;Molecular Disease;molecular modeling;Mus;Mutagenesis;mutant;Mutation;Nature;Neurons;new therapeutic target;novel;Oligosaccharides;overexpression;Pathogenesis;Pathway interactions;Pattern;Play;Polysaccharides;Predisposition;Protein Isoforms;Research;Research Support;Resolution;Risk;Role;sex;structural biology;Structural Models;Sulfate;sulfotransferase;Surface;Surface Plasmon Resonance;tandem mass spectrometry;tau Proteins;Testing;Thermodynamics;uptake;Validation

PROJECT_TITLE: ApoE and Heparan Sulfate Interaction in Alzheimer’s Disease

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative  We seek to accelerate detection and tracking of the earliest cognitive changes associated with Alzheimer’s disease (AD) by exploring aberrations in memory consolidation (an aspects of learning whereby a temporary, labile memory is transformed into a more stable, lasting form), which, recent evidence suggests, may be a very early cognitive indicator of preclinical AD. We will employ remote, unsupervised, web-based cognitive testing to quantify individualized multi-day learning curves (MDLC) on memory and processing speed tests, repeated daily for 10 minutes/day over one week to determine whether MDLC, in contrast with standard cognitive assessments, are associated with AD biomarkers, predictive of prospective cognitive decline and clinical progression, and more sensitive indicators of change when captured semi-annually; we will assess this first leveraging well-characterized older adults with molecular neuroimaging AD biomarkers spanning the AD continuum from cognitively unimpaired (CU) to subjective cognitive decline (SCD) to Mild Cognitive Impairment (MCI) (n=250) and subsequently determine if findings are generalizable to a larger (n=400) more diverse (>24% URG) community cohort of CU older adults with novel plasma AD biomarkers. Ultimately, we seek to provide a rapidly obtainable, repeatable, high-resolution snapshot of clinically relevant memory decrements across the very early AD continuum to facilitate early detection of worrisome memory decrements in the general population and to provide a more sensitive method to monitor cognitive change.

PI_NAMEs: PAPP, KATHRYN VICTORIA (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Acceleration;Acquaintances;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;Area;Area Under Curve;Biological Assay;Biological Markers;Blood;Boston;Clinic;Clinical;clinically relevant;Cognitive;cognitive change;cognitive testing;cohort;Communities;Data;Deposition;Detection;Devices;digital;Disease;Early Diagnosis;Early identification;Early treatment;Evaluation;experience;Face;formycin triphosphate;Future;General Population;Gold;Growth;Health;Image;Impaired cognition;improved;Individual;Learning;Life;Measures;Memory;memory consolidation;Memory Loss;Methods;mild cognitive impairment;Molecular;Monitor;Names;Neurocognitive;neuroimaging;novel;older adult;Online Systems;Outcome;Paper;Participant;Pattern;Performance;Plasma;Positron-Emission Tomography;pre-clinical;Prevention;processing speed;prospective;Reaction Time;recruit;remote assessment;Research Personnel;Resolution;response;Risk;screening;standard measure;Stimulus;Symptoms;tau Proteins;Testing;Therapeutic Intervention;Time;time interval;treatment response;Underrepresented Populations;web platform;Work;β-amyloid burden

PROJECT_TITLE: Ahead of the Curve: Early detection and monitoring of learning decrements in Alzheimers disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Mental Health;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Caring for people living with dementia (PLWD) can be highly stressful, and is associated with negative mental health outcomes, including depression and anxiety. High levels of cognitive empathy have been associated with lower levels of subjective stress and depression among dementia caregivers. The goal of this project is to investigate the effect of cognitive empathy training on mental health, inflammation and immune function in caregivers of people living with dementia, and to examine the underlying psychological and neurobiological mechanisms.

PI_NAMEs: HEPBURN, KEN W;RILLING, JAMES K (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Adopted;Age;aging related disease;Alzheimer's Disease;American;Antibody titer measurement;Anxiety;Area;Automobile Driving;behavioral and social science;Biological Assay;Biological Markers;Blood;Brain;Brain region;care giving burden;care recipients;Caregiver Burden;Caregiver research;Caregiver well-being;Caregivers;caregiving;Caring;Cellular Phone;Chronic Disease;Chronic stress;Cognitive;cognitive enhancement;Crossover Design;cytokine;Dementia;dementia care;Dementia caregivers;Effectiveness;emotion regulation;Emotional;Empathy;Exercise;experience;Family member;Feeling;Functional Magnetic Resonance Imaging;Goals;Home;Human Herpesvirus 4;human old age (65+);immune function;improved;Individual;Inflammation;Inflammatory;interest;Interleukin-10;Interleukin-6;Intervention Studies;Interview;Journalism;Literature;Measures;Mediating;Mental Depression;Mental Health;Modeling;neural;neurobiological mechanism;Outcome;Parent-Child Relations;Parents;Participant;Patient Self-Report;Personal Satisfaction;Persons;Pilot Projects;Prefrontal Cortex;Psyche structure;psychologic;Quality of Care;Questionnaires;Race;Randomized;recruit;response;Same-sex;Sampling;Scanning;Spottings;Stress;Text;Thinking;Time;TNF gene;Training;Well in self;Work

PROJECT_TITLE: Effect of Cognitive Empathy Training on Dementia Caregivers

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Current anti-VEGF agents offer benefits in the treatment of retinopathy of prematurity (ROP) by reducing the destruction of the peripheral avascular retina caused with laser. Anti-VEGF also extends developing vasculature into the peripheral avascular retina, but advances in treatments are still needed to improve safety and efficacy. Our lab studies VEGF signaling pathways in order to discover better strategies to safely extend vascularization into the peripheral avascular retina and effectively inhibit vision-threatening ROP.

PI_NAMEs: HARTNETT, MARY ELIZABETH RUTH (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Adaptor Signaling Protein;Adverse event;Affect;analog;Anemia;angiogenesis;Blood Vessels;C-terminal;Cell division;Cell model;cell motility;Cell Proliferation;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Disease;disease model;effective therapy;Electroretinography;Endothelial Cells;Endothelial Growth Factors Receptor;Endothelium;Engineering;Erythropoietin Receptor;Event;Extracellular Signal Regulated Kinases;Functional disorder;Future;Genes;Guanosine Triphosphate Phosphohydrolases;Human;humanized mouse;Image;improved;In Vitro;Infant;KDR gene;knock-down;Knock-out;Lasers;Learning;Lentivirus;Mediating;Methods;Modeling;Mus;mutant;Mutation;neovascularization;neural;Neural Retina;Neurocognitive Deficit;Neurophysiology - biologic function;neuroprotection;novel;Optical Coherence Tomography;Oxygen;Pathologic;Pathologic Neovascularization;Peripheral;phosphatase inhibitor;Phosphorylation;Physiological;premature;Premature Infant;Protective Agents;Protein Tyrosine Phosphatase;Proteins;Pulmonary Hypertension;Rattus;Receptor Signaling;Recovery;Regulation;Reporting;Retina;retinal damage;Retinal Diseases;Retinopathy of Prematurity;Safety;Signal Pathway;Signal Transduction;Site;small hairpin RNA;standard care;STAT3 gene;Testing;Transgenic Mice;Transgenic Organisms;Treatment Factor;Tyrosine;Tyrosine Phosphorylation Site;Vascular Endothelial Growth Factors;Vascularization;Vision;Visual Fields;Wild Type Mouse

PROJECT_TITLE: Mechanisms of Angiogenesis in ROP

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE Taking advantages of our novel methods, this project will be the first to investigate the alterations in functional interactions between brain white matter and gray matter resulting from sensory and motor dysfunctions in preclinical Alzheimer’s disease (AD). The outcomes will offer novel insights into the neural basis of sensory and motor dysfunctions in AD and contribute to seeking biomarkers for prediction of early AD, which will eventually improve the well-being of both the aging population and their caregivers.

PI_NAMEs: GAO, YURUI  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Adult;Affect;Age;Aging;aging population;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;amyloid pathology;Architecture;Atlases;Behavior;Biological;Biological Factors;Brain;Caregivers;cerebral atrophy;Clinical;Code;Cognition;cohort;Communities;Complex;connectome;Data;Databases;denoising;density;Deposition;design;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Early Diagnosis;Elderly;Evaluation;Failure;Family;Fiber;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Graph;gray matter;Image;Impaired cognition;improved;innovation;insight;interest;Knowledge;Link;Measures;Mediator;Mental Depression;Methodology;Methods;mild cognitive impairment;Modeling;Motor;motor disorder;Nature;neglect;neural;novel;Outcome;Pathway Analysis;Pathway interactions;Personal Satisfaction;Pilot Projects;Population;potential biomarker;pre-clinical;predictive marker;Property;Research Personnel;Resolution;response;Role;Sensory;sex;Shapes;Signal Transduction;Skeleton;Statistical Data Interpretation;Statistical Methods;Structure;System;Testing;Thinness;Tissues;tool;white matter

PROJECT_TITLE: Influence of Sensory and Motor Dysfunctions on White - Gray Matters Functional Connectome in Preclinical AD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-Q (81)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Heart Disease;Mental Health;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Sleep Research

PHR: PROJECT NARRATIVE Postoperative delirium (POD) is a burdensome clinical and patient-centered outcome associated with long-term cognitive deficits like Alzheimer's Disease (AD) and Related Dementias (AD/RD). This pragmatic randomized controlled trial aims to provide the definitive evidence needed to support the widespread implementation of nighttime intravenous and sublingual dexmedetomidine for POD prevention in an increasingly vulnerable population of elderly patients undergoing cardiac surgery. Given plausible bidirectional links between POD and ADRD, POD prevention may reduce the incidence of ADRD by delaying the progression of underlying ADRD vulnerabilities.

PI_NAMEs: JOHNSON-AKEJU, OLUWASEUN  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Academic Medical Centers;Acute;Adrenergic Agonists;aged;Alzheimer's disease related dementia;Anti-Inflammatory Agents;arm;Atrial Fibrillation;Attention;biobank;Biological;Biological Markers;biomarker discovery;Blinded;Brain;Cardiac Surgery procedures;Cardiopulmonary Bypass;clinical center;clinical practice;Clinical Trials;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive recovery;cognitive testing;Cohort Studies;Confusion;confusion assessment method;Consensus;daily pain;Data;Dexmedetomidine;Dose;Exertion;experience;Formulation;Guidelines;Health Care Costs;Healthcare;Hospital Mortality;hospital readmission;Hospitalization;Impaired cognition;improved;improvement on sleep;inattention;Incidence;Inflammation;Information Systems;Infusion procedures;innovation;Inpatients;insight;Institutionalization;Intensive Care Units;Intravenous;Investigation;Joints;Kidney Failure;Length of Stay;Link;lipid metabolism;Measurement;Morbidity - disease rate;mortality;Neurologic Dysfunctions;Odds Ratio;older patient;Operative Surgical Procedures;opioid use;Pain;pain score;Pathology;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Perioperative;Pharmaceutical Preparations;pharmacologic;Phase;pilot trial;Placebo Control;Placebos;Plasma;postoperative delirium;Postoperative Period;pragmatic trial;prevent;Prevention;Prevention strategy;Property;prophylactic;Protein Isoforms;Public Health;Randomized;Randomized, Controlled Trials;readmission rates;Recovery;Research;Resources;Rest;Sampling;Serum;Severities;Sleep;sleep quality;stressor;Stroke;tau Proteins;tau-1;Tauopathies;Telephone;three-arm study;three-arm trial;Toxin;United States;United States Food and Drug Administration;Vulnerable Populations

PROJECT_TITLE: Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS II)

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE The Cooperative Human Tissue Network (CHTN) was established to address the increasing demand by the scientific community for access to high-quality human biospecimens for research. The scientific community can request CHTN biospecimens to perform cutting-edge research, including basic and translational cancer research, as well as assay development. The goal of the Pediatric Division of the CHTN is to support pediatric and adolescent research (including cancer) by collecting, processing, and distributing high quality biospecimens to approved investigators.

PI_NAMEs: RAMIREZ MILAN, NILSA DEL CARMEN (contact)

PROGRAM_OFFICER_NAME: CHUAQUI, RODRIGO F

PROJECT_TERMS: Acute Disease;Address;Adolescent;Adolescent and Young Adult;assay development;Basic Cancer Research;Behavior;Benign;Biological;Biological Assay;Biological Specimen Banks;cancer therapy;Cancerous;Child;Childhood;Chronic Disease;Collaborations;Collection;Communities;Cooperative Human Tissue Network;Data;Diagnosis;digital imaging;Disease;Ensure;Fostering;Goals;Hospital Departments;Human;improved;Individual;Laboratories;Malignant - descriptor;Malignant Neoplasms;Medicine;Monitor;Nucleic Acids;Pathology;Pediatric Hospitals;Pediatric Oncology Group;privacy protection;Process;programs;prospective;rare cancer;Research;research and development;Research Institute;Research Personnel;Resources;satisfaction;Slide;Specific qualifier value;Tissue Microarray;Tissue Stains;translational cancer research;Treatment Side Effects

PROJECT_TITLE: Cooperative Human Tissue Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (J1)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative: Pseudomonas is a common multidrug resistant bacterium that causes diverse infections that can be difficult to treat. Isolates are found that are resistant to all known antibiotics. Bacteriophages, viruses that prey upon bacteria are a possible solution to this. This proposal will study interactions within bacteriophage cocktails, providing critical data to guide treatment of this challenging pathogen.

PI_NAMEs: NICHOLLS, PAUL  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Adult;Affect;antibiotic resistant infections;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Atomic Force Microscopy;Attenuated;attenuation;Award;Bacteria;Bacterial Antibiotic Resistance;bacterial fitness;Bacterial Infections;bacterial resistance;Bacteriophages;Basic Science;Biology;Biomechanics;career;career development;Catheters;Cefepime;Cephalosporins;Chemicals;Child;Chronic;Clinical;clinical practice;clinically relevant;college;Combined Antibiotics;Communicable Diseases;Complement;Cystic Fibrosis;Data;data integration;design;Development;Development Plans;Devices;Drug resistance;drug resistant bacteria;Ensure;Environment;Epidemic;Evolution;experience;Exposure to;Extracellular Matrix;fitness;Generations;Genetic;genome sequencing;Goals;Growth;infancy;Infection;insight;interest;Intravenous;K-Series Research Career Programs;Knowledge;laboratory facility;Lead;Libraries;Literature;Measures;Mediating;Medicine;meetings;Mentors;Mentorship;Methods;Microbial Biofilms;Modulus;Molecular Target;Multiple Bacterial Drug Resistance;nanomechanics;Nature;Osteomyelitis;particle;pathogen;pathogenic bacteria;Pathway interactions;Patients;Persons;Phenotype;Planet Earth;Play;pressure;Probability;professor;Property;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;rational design;Recovery;Research;research and development;Research Personnel;resilience;Resistance;Respiratory Tract Infections;Science;Scientist;success;Survivors;synergism;Testing;Therapeutic;therapeutically effective;Thick;Time;Training;United States National Institutes of Health;urinary;ventilator-associated pneumonia;ventricular assist device;Virulence;Virulence Factors;Virus;whole genome;Work

PROJECT_TITLE: Interactions and mechanisms of bacteriophages and antibiotics in phage cocktails

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Biotechnology;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

ORG_NAME: RAMONA OPTICS, INC.

PHR: Narrative: Zebrafish is an excellent model for screening Developmental Neurotoxicity (DNT). However, neuroimaging and neurobehavior assessments for DNT screening are imaging based, and are manual and limited in throughput with critical gaps in high-throughput morphological assessments. The proposed MCAM-DNT imaging system with its novel “periscopic” multi-well plate will be the first system to integrate 2D behavioral as well as 3D behavioral, lateral morphology, dorsal morphology and gross fluorescence imaging assessments for DNT screening. This will be a significant leap in DNT screening using zebrafish for throughput, automation and standardization of assessments on one integrated system.

PI_NAMEs: HARFOUCHE, MARK  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: 3-Dimensional;automated analysis;automated segmentation;Automation;Axon;Behavior;Behavioral;Biological Assay;Categories;Computer software;Control Groups;Data;Development;developmental neurotoxicity;Dimensions;DNA Microarray Chip;Dorsal;environmental chemical;experimental study;Feedback;Fishes;Fluorescence;fluorescence imaging;Gene Expression Profiling;Grant;Hour;Human;Image;imager;imaging approach;imaging system;improved;Individual;innovation;insight;Lateral;Length;Lighting;Mammals;Manuals;Measures;member;meter;Methods;Microscope;model organism;Modeling;Morphology;Motor;nervous system development;neurobehavior;neurobehavioral;neurobehavioral test;neurodevelopment;neuroimaging;Neurotoxins;non-invasive monitor;novel;Oryziinae;Output;Pathway interactions;Pattern;Phase;Poison;protein expression;Recommendation;Resolution;response;Risk Assessment;Scanning;screening;small molecule libraries;software systems;sound;Standardization;Stimulus;Swimming;System;Systems Integration;Technology;Testing;Time;treatment group;usability;Visualization;Zebrafish

PROJECT_TITLE: Integrating developmental neurotoxicity screening using automated neuro-behavioral, morphological and neuro-developmental tests in the larval zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-D (R4)]


NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Cooperative Human Tissue Network Eastern Division NARRATIVE CHTNED provides high quality human bio specimens to support research in cancer, autoimmunity, and other classes of human diseases. These research projects advance understanding of disease development leading to new diagnostic and therapeutic modalities. These in turn benefit public health by allowing screening procedures for diseases in preclinical asymptomatic stages and defining new therapies to patients with fully developed and even late stage disorders.

PI_NAMEs: MONTONE, KATHLEEN T. (contact)


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: SAN ANTONIO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF THE INCARNATE WORD

PHR: Project Narrative: The acquisition of a liquid chromatography system will provide research and teaching communities at the University of the Incarnate Word with access to current instrumentation to purify proteins while also enhancing research experiences for our diverse pool of undergraduate students. This system will improve the capabilities of our research programs and contribute to a deeper understanding of the various roles that proteins play in human diseases.

PI_NAMEs: BOOTH, RACHELL ESCHETTE (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Affinity Chromatography;Biochemical;Biochemistry;career;career preparation;Cell Physiology;Cementation;Chemistry;Chromatography;Collaborations;Communities;Education;Educational process of instructing;equipment acquisition;Faculty;First Generation College Students;Force of Gravity;Funding;human disease;laboratory curriculum;Laboratory Research;Lead;Liquid Chromatography;Pathway interactions;Play;Population;programs;protein purification;Proteins;Research;Research Activity;Role;skill acquisition;skills;student participation;Students;System;Techniques;undergraduate student;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Liquid Chromatography System with Fraction Collector

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (30)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Physical inactivity is a public health crisis and a major contributor to chronic disease disparities, which disproportionately impact low-income, minoritized communities because of historical disinvestments and institutional bias that result in suboptimal access to safe, quality active transportation options and places for active play, recreation, and sports. We propose to conduct a comprehensive, community-engaged, equity- driven study to design and test strategies for improving individual-level and community-wide physical activity outcomes in low-income, middle school communities with high proportions of minority students and residents.

PI_NAMEs: HOELSCHER, DEANNA MARIE (contact);SALVO, DEBORAH

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Active Biological Transport;active lifestyle;Address;Adolescence;Adolescent;Adult;Air;Black race;cancer type;Cardiovascular Diseases;Catchment Area;Child;Childhood;Chronic Disease;Cities;Climate;cognitive function;Communities;community barrier;community intervention;community partners;community setting;community-level factor;concept mapping;COVID-19 pandemic;Crime;Dementia;design;disease disparity;Disparity;Disparity population;early adolescence;Economics;Effectiveness;effectiveness testing;elementary school;Equity;Ethnic Origin;Ethnic Population;Evaluation;Exercise;exercise intervention;experience;Family;Generations;Guidelines;health equity;Improve Access;improved;Income;Individual;Institution;Intervention;junior high school;Knowledge;late life;Latino;learning outcome;Leisures;Life;life span;Low income;Maintenance;meetings;member;Methods;Middle School Student;Minority;minority children;minority communities;Minority Groups;minority student;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Osteoporosis;Outcome;pandemic disease;Parents;Phase;Physical activity;Physical Education;physical inactivity;Play;programs;Public Health;Quality of life;Race;racial disparity;racial population;Recreation;Research;Research Personnel;resilience;Risk Factors;Safety;scale up;Schools;segregation;social capital;social cohesion;social health determinants;Social Justice;socioeconomics;Sports;Structure;Students;Surveys;Testing;therapy development;Transportation;Travel;trend;United States;urban minority;vigorous intensity;Work;Youth

PROJECT_TITLE: Co-creating and implementing contextually responsive physical activity interventions with low-income adolescents

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 IN (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  Altered lipid metabolism in the brain is an early event in patients with Alzheimer’s disease (AD). The proposed program of research determines how disrupted lipid metabolism initiates and how it promotes AD onset and progression. Outcomes of this research will provide novel insights into the multifactorial nature of AD and explore therapeutic opportunities by restoring lipid balance in the brain.

PI_NAMEs: YIN, FEI  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: abeta deposition;abeta oligomer;Affect;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapeutic;Amyloid;Amyloid beta-Protein;amyloid pathology;Amyloidosis;apolipoprotein E-4;Astrocytes;astrogliosis;Automobile Driving;Autopsy;beta amyloid pathology;Brain;brain cell;Brain region;cell type;Cholesterol;Clinical;Cognitive deficits;Cohort Studies;Dementia;Disease;Disease Progression;Equilibrium;Essential Fatty Acids;Event;fatty acid metabolism;Fatty Acids;Gene Delivery;Genes;genetic risk factor;Genetic Transcription;glucose metabolism;Homeostasis;Impaired cognition;Impairment;In Vitro;in vivo;insight;Intervention;Link;lipid metabolism;lipid transport;lipidomics;Lipids;Mediating;Metabolic;Mitochondria;Modeling;mouse model;multiple omics;Mus;myelin degeneration;Nature;Nerve Degeneration;neuroinflammation;Neurons;neuropathology;neuroprotection;Nonesterified Fatty Acids;novel;Onset of illness;Outcomes Research;oxidation;Oxidative Phosphorylation;Pathogenesis;Pathologic;Pathology;Peripheral;Persons;Phenotype;Pilot Projects;PPAR alpha;pre-clinical;programs;Reporting;Research;response;risk variant;Role;Synapses;tau aggregation;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutic target;Time;vascular abnormality;Virus;Work

PROJECT_TITLE: Disrupted Lipid Metabolism in Alzheimer's Disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The generation of virus-neutralizing antibodies is essential for recovery from infection and for the development of protective vaccines. Stimulation of antibody production requires detection of the infection and activation of downstream signaling networks. This project will reveal the genetic basis for a previously unknown pathway for the detection of retroviral infection and stimulation of anti-viral antibody production.

PI_NAMEs: KANE, MELISSA E (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: adaptive immune response;Address;Animal Model;Anti-Retroviral Agents;Antibodies;Antibody Formation;Antibody Response;Antigen-Presenting Cells;Antigens;B-Lymphocytes;BALB/cJ Mouse;C57BL/6 Mouse;CD4 Positive T Lymphocytes;cell type;Cells;chromosomal location;Congenic Mice;Detection;Development;Disease;Dissection;Endosomes;forward genetics;Generations;Genetic;genetic approach;genetic makeup;genetic manipulation;Goals;Hematopoietic;Human;human disease;human model;I/LnJ Mouse;Immune;Immune Evasion;Immune response;Immune signaling;Immunity;Immunologic Receptors;Immunologics;Inbred Mouse;Inbred Strain;Individual;Infection;Inherited;innate immune mechanisms;Innate Immune System;insight;Interferon Type I;Interferon Type II;Investigation;Knowledge;mammary tumor virus;Mediating;model organism;Molecular;Mouse Mammary Tumor Virus;mouse model;Murine leukemia virus;Mus;neutralizing antibody;novel;novel therapeutic intervention;pathogen;Pathogen detection;Pathway interactions;Pattern recognition receptor;Phenotype;Predisposition;prevent;Probability;Production;receptor;Recovery;Resistance;resistance gene;response;Retroviridae;reverse genetics;RNA;RNA Virus Infections;sensor;Signal Pathway;Signal Transduction;TLR7 gene;tool;Translating;Tumor Virus Infections;Up-Regulation;Vaccines;Viral;Viral Antibodies;viral detection;viral RNA;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Genetic basis for TLR7-independent antiretroviral antibody responses

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]