NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Underage Drinking;Women's Health Research

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE This revised proposal addresses HIV prevention and treatment for young couples through a comprehensive biobehavioral multilevel approach. We plan to conduct stigma-reduction training in clinics and to address alcohol and other drug use, gender-based violence, sexual risk within couples and with other partners, and uptake and adherence to HIV prevention and HIV treatment, with the overarching aim of preventing new cases of HIV.

PI_NAMEs: BROWNE, FELICIA AMIRA (contact);CARNEY, TARA

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;Adherence;Age;Age Years;aged;AIDS prevention;alcohol and other drug;Alcohol consumption;antiretroviral therapy;Attitude;Behavior;Behavior Therapy;biobehavior;burden of illness;Caring;Catchment Area;Clinic;Cluster randomized trial;Communication;Communities;condoms;Continuity of Patient Care;Couples;critical period;design;Discrimination;Drug usage;economic disparity;effective intervention;efficacy testing;empowerment;Ensure;Epidemic;evidence base;Fright;frontier;Gender;Gender Role;gender-based violence;Goals;Government;Health;Health Policy;Health Services Accessibility;Heterosexuals;HIV;HIV Infections;Human immunodeficiency virus test;Impairment;improved;Incidence;Individual;Intervention;Knowledge;Learning;life span;male;Mediation;Methods;National Institute of Drug Abuse;neighborhood disadvantage;novel strategies;Oral;Outcome;peer;Persons;Pharmaceutical Preparations;Phase;pre-exposure prophylaxis;prevent;Prevention;programs;Public Health;Randomized;Reporting;Reproductive Health Services;Risk;Risk Behaviors;Service provision;Services;sex risk;sexual and reproductive health;Sexual Partners;sexual risk behavior;sexually active;skills;social stigma;South Africa;Staff Attitudes;Stigmatization;syndemic;Testing;testing services;Training;transmission process;treatment as prevention;United States;Unsafe Sex;uptake;Viremia;Virus;Woman;Women's prevalence;young adult;young woman

PROJECT_TITLE: Resubmission: Multilevel Strategies & Tailored HIV Prevention & Care for Young Couples who use Alcohol & Other Drugs Across Cape Town

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative This study will uncover fundamental molecular mechanisms that regulate neural circuit development through interactions between cell surface proteins. Although our work is conducted in Drosophila, there is a subfamily of human proteins that corresponds to the Dprs and DIPs, called the IgLONs, which are important for neural circuit formation and have been linked to autism, schizophrenia, and dyslexia. By establishing how these proteins instruct precise neural circuit development, our work will build a foundation for clinical approaches to treat these debilitating diseases.

PI_NAMEs: CARRILLO, ROBERT ARNULFO (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Address;Affect;Affinity;autism spectrum disorder;Automobile Driving;Axon;axon guidance;Binding;Binding Proteins;Cell Communication;Cell Surface Proteins;Cells;Clinical;Code;Collaborations;combinatorial;Complex;Cues;Data;Development;Developmental Process;Disease;Drosophila genus;Dyslexia;Family;Foundations;Genes;Genetic;genetic approach;genetic manipulation;Goals;Growth;Homo;Human;Immunoglobulins;Individual;insight;Link;Maps;Mediating;member;Modeling;Molecular;Morphology;Motor Activity;Motor Neurons;Multigene Family;Muscle;mutant;Nervous System;Nervous System Disorder;neural;neural circuit;Neurobiology;neuromuscular;neuromuscular system;Neurons;novel;Pathway interactions;Pattern;Play;Positioning Attribute;postsynaptic;presynaptic;Presynaptic Terminals;Process;programs;Property;Proteins;Reagent;Regulation;Research;Resolution;Role;Schizophrenia;Shapes;Signal Pathway;Signal Transduction;Specific qualifier value;Specificity;Stereotyping;Structure;Synapses;synaptic function;synaptogenesis;Testing;Variant;Visual;Work

PROJECT_TITLE: IgSF protein interactions drive specificity in circuit wiring and synaptic elaboration

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Genetics;Human Genome;Mental Health;Mental Illness;Microbiome;Neurosciences;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: TEMPE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE More than 5% of US children and 45% of US adolescents have anxiety or depression; to identify effective treatment targets to address this growing concern we must first understand early childhood contributing factors. We will investigate the influence of early life stress and gut microbiome in relation to childhood and adolescent mental health. We will assess these questions using twins to identity genetic and environmental influences on mental health, which will pinpoint aspects of the environment, unrelated to genetic influences that are potential treatment targets for anxiety and depression.

PI_NAMEs: LEWIS, CANDACE RENEE (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Adolescence;Adolescent;adolescent mental health;Adrenal Glands;Affective;Anti-Bacterial Agents;Anxiety;Arizona;bead chip;Behavior;behavior influence;Behavioral;behavioral phenotyping;Bifidobacterium;Brain;Breast Feeding;Child;Child Health;Childhood;Clinical;Clinical Trials;cohort;Communities;comorbidity;Data;Data Analyses;Development;Diet;DNA;DNA Methylation;early childhood;early life stress;Economic Burden;effective intervention;effective therapy;Emotional;Environment;Epigenetic Process;epigenome;Etiology;Folic Acid;Future;Generations;Genes;Genetic;Genetic Identity;gut microbiome;gut microbiota;gut-brain axis;Human;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Immune response;infancy;Infection;insight;Intervention Trial;Joints;Knowledge;Lactobacillus;Life;Maternal Age;maternal depression;Mediating;Mediation;Mental Depression;Mental disorders;Mental Health;Metadata;Methods;Methylation;methylation pattern;microbiome;microbiome composition;microbiota;microbiota composition;Modeling;neurodevelopment;Outcome;Pathway interactions;Phase;Physiology;Pituitary Gland;Play;Population;Prevotella;Process;prospective;Psychosocial Stress;recruit;Research;Role;Sampling;Signal Transduction;Stress;stress reduction;Taxonomy;Testing;Therapeutic;Time;treatment trial;Twin Multiple Birth;Work

PROJECT_TITLE: Host DNA methylation as a mechanism of microbiome influence on internalizing behavior

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PI_NAMEs: MARSCH, LISA A. (contact)

PROJECT_TERMS: adaptive intervention;Address;Algorithms;analytical method;Area;Authorization documentation;base;Behavior Therapy;Behavioral;behavioral health;Behavioral Sciences;Characteristics;Collaborations;Communities;Computer software;contextual factors;cost;Data;Data Analytics;Data Set;data sharing;design;Development;Diagnostic;digital;digital treatment;Discipline;Dissemination and Implementation;Doctor of Philosophy;Education;Educational workshop;effective intervention;Emerging Technologies;Ethics;Evaluation;Faculty;faculty community;Goals;Grant;Guidelines;Home;implementation science;Individual;industry partner;innovation;interdisciplinary collaboration;International;Intervention;Learning;Libraries;Licensing;Measures;Mental Health;Mentors;Methods;multimodal data;new technology;novel;novel strategies;Paper;personalized intervention;Phenotype;physical conditioning;Physiological;Pilot Projects;Postdoctoral Fellow;Process;Publishing;Research;Research Personnel;Research Support;Resource Sharing;Resources;Scientist;sensor;sensor technology;Series;student training;Students;Substance Use Disorder;substance use treatment;Technology;terabyte;therapy development;Time;Underrepresented Populations;usability;user centered design;Visualization

PROJECT_TITLE: Emerging Technologies & Data Analytics Core


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: At the onset of COVID-19, primary care (PC) at the VA had a substantial increase in video-based encounters nationwide. However, this rapid uptake of video-based care during the pandemic varied by site. Given that the VA is committed to continue expanding VA Video Connect (VVC) as its videoconferencing platform, more research is needed to identify strategies to improve VVC use for all Veterans, nationally. [In-depth analysis of VA data will inform multilevel (patient, provider, site) characteristics and predictors of VVC use. Qualitative interviews with key stakeholders (patients, providers, and leadership) at identified high and low VVC sites, as well as qualitative analyses of VA documents from these selected sites, will allow us to develop patient-centered, provider-recommended, leadership-supported policies, procedures, and processes about how to improve delivery of VVC care at the VA. This 18-month pilot study will create context-specific VVC playbook for high and low VVC using sites, which will help improve delivery of video-based primary care at the VA.]

PI_NAMEs: ROSE, DANIELLE ELISE (contact)

PROJECT_TERMS: Adopted;Ambulatory Care;care delivery;care outcomes;Caregivers;Caring;Characteristics;Clinical;Collaborations;COVID-19;COVID-19 pandemic;Data;Data Collection;Development;Effectiveness;effectiveness evaluation;Equipment;experience;Familiarity;Feedback;Future;Guidelines;Health;health care delivery;Health Personnel;Home;improved;Individual;innovation;Interruption;Intervention;Interview;Knowledge;Leadership;Learning;Literature;Logistics;Maps;Methodology;Methods;Modality;operation;pandemic disease;patient oriented;Patient-Focused Outcomes;Patients;Persons;Pilot Projects;pilot test;Policies;preference;Primary Care;primary care clinic;primary care patient;Procedures;Process;Provider;Qualitative Research;Recommendation;Regression Analysis;Research;Research Personnel;sample collection;scale up;Schedule;Site;Structure;success;sustainability framework;Technology;telehealth;Telephone;Time;Time Series Analysis;Training and Education;Update;uptake;usability;Variant;Veterans;video delivery;Videoconferencing;virtual;Visit;willingness;Work

PROJECT_TITLE: Understanding and Improving Video-Based Primary Care Delivery to Veterans

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Sexual reproduction in animals requires first the formation of primordial germ cells during embryogenesis since these cells are the progenitors of eggs and sperm in the adult. In mammals, these cells are selected by signaling between cells, whereas in some other vertebrates, these same cells are selected based on what they inherit from the egg. We will decode these distinct mechanisms, and how these cells can be regenerated, by use of non- mammalian model organisms enabling longitudinal analysis, direct visualization, and multiple state-of-the-art molecular technologies to understand the process at the heart of sexual reproduction.

PI_NAMEs: WESSEL, GARY M (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adult;animal resource;Animals;Biochemical;Biological;Biology;Biomedical Research;Cell Lineage;Cell Transplantation;Cells;Cellular biology;Characteristics;Chordata;chromatin modification;Complex;Coupled;CRISPR/Cas technology;Development;Drops;Echinodermata;egg;Embryo;Embryonic Development;Evaluation;Event;expiration;Female;Gene Expression;Genes;genetic manipulation;Genomics;Germ Cells;Germ Lines;Heart;in vivo;in vivo evaluation;Inherited;innovation;Knowledge;longitudinal analysis;male;Mammals;Manuals;Metabolic;model organism;Modeling;Molecular;Morphology;mRNA sequencing;Natural regeneration;Oligonucleotides;optical imaging;optogenetics;Organism;posttranscriptional;Process;Reagent;regenerative cell;Resolution;Sea Urchins;serial imaging;Sexual Reproduction;Signal Pathway;Signal Transduction;Sister;small molecule;Specific qualifier value;sperm cell;Starfish;stem cells;Sterility;Structure of primordial sex cell;System;Technology;Tissue Transplantation;trait;Transplantation;Vertebrates;Visualization;Work

PROJECT_TITLE: Mechanisms of specification, quiescence, and regeneration of primordial germ cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Substance Misuse

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Alcoholic liver disease (ALD) affects more than 10 million people in the U.S. and accounts for nearly half of the liver cirrhosis-associated deaths. Our preliminary studies have demonstrated that NOX2-deficient neutrophils exhibit an enhanced inflammatory phenotype and impairs resolution from alcohol-induced liver inflammation and injury. The current project aims to better understand the molecular mechanism(s) accounting for the functions of NOX2-deficient neutrophils and to evaluate the potential of targeting neutrophil-specific NOX2 as treatment for ALD. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page

PI_NAMEs: JU, CYNTHIA  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Accounting;Adoptive Transfer;Adrenal Cortex Hormones;Affect;Agonist;Alcoholic Hepatitis;Alcoholic Liver Cirrhosis;Alcoholic Liver Diseases;Alcohols;Attenuated;Cells;Cessation of life;Chronic;Data;Defect;Development;Disease;effective therapy;Ethanol;Exhibits;Goals;Impairment;Infection;Inflammasome;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;insight;Knowledge;Liver;Liver Cirrhosis;liver inflammation;liver injury;liver transplantation;Macrophage;Mitochondria;Modeling;Molecular;molecular marker;Mus;NADPH Oxidase;National Institute on Alcohol Abuse and Alcoholism;neutrophil;novel;Pathogenesis;Pathway interactions;Patients;Pentoxifylline;Persons;Pharmacologic Substance;Phase;Phenotype;Play;Predisposition;Production;Reactive Oxygen Species;Resolution;Role;Serine Protease;Source;therapeutic development;therapeutic target

PROJECT_TITLE: Role of neutrophil-specific NOX2 in alcohol-induced liver injury

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Substance Misuse;Telehealth

PROJECT_TERMS: Achievement;Address;Applications Grants;Area;Award;Behavior;behavior change;behavioral health;Behavioral Sciences;Blinded;Collaborations;Communities;Complement;computer science;Data;Data Science;deep learning;design;Development;Devices;digital;digital applications;digital health;digital intervention;digital phenotyping;digital technology;digital treatment;Discipline;diversity and inclusion;Doctor of Philosophy;Education Projects;Eligibility Determination;Emerging Technologies;Engineering;Ethics;Evaluation;experience;Extramural Activities;Faculty;Foundations;Funding;Funding Mechanisms;Funding Opportunities;Future;Glean;Grant;Health;Health behavior;Health Priorities;implementation science;innovation;insight;instructor;Intervention;intervention delivery;Investigation;Knowledge;Literature;Machine Learning;Measures;Methodology;minority investigator;Mission;Modeling;National Institute of Drug Abuse;Nature;novel;Peer Review;Phase;Pilot Projects;Postdoctoral Fellow;preservation;prevent;Process;professor;programs;Publications;Request for Applications;Research;Research Activity;Research Personnel;Research Project Grants;response;Science;Scientist;Speed;substance use;Substance Use Disorder;substance use treatment;synergism;Technology;Testing;Therapeutic Intervention;time interval;Training;Underrepresented Minority;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;wearable sensor technology;Work

PROJECT_TITLE: Pilot Project Core


ORG_CITY: MINNEAPOLIS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  Pyrazoles are an important class of bioactive molecules that are found in many FDA-approved drugs such as celecoxib (Celebrex®), a non-steroidal anti-inflammatory used to treat arthritis, and apixaban (Eliquis®), an anti-coagulant used to treat blood clots and prevent strokes. Although pyrazoles are commonly used in medicinal chemistry, their synthesis often relies on using potentially toxic hydrazine reagents in reactions with poor regiocontrol. A general synthesis of pyrazoles that avoids the use of these reagents is an unmet challenge. The objective of this proposal is to design a general synthesis of pyrazoles from alkynes and nitriles, forming the key N-N bond in the pyrazole using titanium catalysts. This strategy, and the related method for making N-N bonds and other heteroatom-carbon bonds, will allow synthetic chemists to access diverse molecular building blocks that will ultimately aid in widespread distribution of new drug-like architectures to the biomedical community.

PI_NAMEs: TONKS, IAN ALBERT (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Ti-Catalyzed Oxidative Amination Reactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Services;Palliative Care;Primary Health Care

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Delivering goal-concordant care is a cornerstone of high-value palliative care and is considered the most important outcome measure for advanced care planning, but no gold standard for measurement exists. Consequently, this project will create a valid and reliable patient-reported experience measure (PREM) that measures goal-concordant care for seriously ill older adults with multiple chronic conditions (MCC), a vulnerable population who often face treatment tradeoffs that require difficult choices. In line with the NIH’s mission, this PREM establishes a patient-centered quality indicator for palliative care delivery that also provides point-of-care feedback to help clinicians better meet the dynamic needs of seriously ill older adults with MCC at both the patient- and population-level.

PI_NAMEs: CHUA, ISAAC SHIN (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Advance Care Planning;Affect;Appointment;arm;beneficiary;care delivery;Caring;Clinical;cognitive interview;cognitive testing;Collection;Data;Death Rate;design;Development;Documentation;effectiveness measure;Elderly;Electronic Health Record;end of life;Ensure;experience;Face;Family;Family member;Feasibility Studies;Feedback;field study;Focus Groups;Generations;Goals;Grant;Health;Health system;Hospital Mortality;human old age (65+);implementation measures;implementation science;improved;innovation;Intensive Care;interest;Interview;Life;Life Expectancy;Literature;loved ones;Measurable;Measurement;Measures;Medicare;Methodology;Methods;Mission;multiple chronic conditions;Natural Language Processing;novel;older adult;Outcome;Outcome Measure;Palliative Care;patient oriented;Patient-Centered Care;Patients;Personal Satisfaction;Pilot Projects;point of care;Population;Positioning Attribute;preference;Primary Care;primary care clinic;primary care provider;Process;Property;Psychometrics;Qualitative Methods;Quality Indicator;Reporting;Research Methodology;Research Personnel;response;Science;skills;Structure;structured data;Surveys;Testing;theories;Time;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: A Novel Method for Measuring Goal-Concordant Care in Seriously Ill Older Adults with Multiple Chronic Conditions

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: HERSHEY

ORG_DEPT: PEDIATRICS

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Hispanic/Latino (H/)L children have a 40% higher death rate of B-cell acute lymphoblastic leukemia (B-ALL) than Non-Hispanic Whites (NHW), after correcting for socioeconomic factor. The proposed project studies the mechanisms that regulate growth of leukemia cells from H/L children. Results of these studies will aid in developing a novel therapeutic strategy to improve treatment for leukemia and reverse health disparity in pediatric leukemia.

PI_NAMEs: DOVAT, SINISA  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: 5'-Nucleotidase;6-Mercaptopurine;Adolescent;Affect;Affinity;Alleles;B-Cell Acute Lymphoblastic Leukemia;B-cell precursor acute lymphoblastic leukemia cell;Biological;Biological Models;cancer health disparity;casein kinase II;Chemoresistance;chemotherapy;Child;Childhood Leukemia;Combined Modality Therapy;cytotoxic;Data;Death Rate;DNA Binding;DNA-Binding Proteins;Exhibits;Gene Expression;gene repression;Genes;Genetic;Genetic Transcription;Growth;health disparity;high risk;Hispanic;Human;IGH@ gene cluster;Impairment;improved;In Vitro;in vivo;in vivo evaluation;Incidence;inhibitor;insight;knock-down;Latino;leukemia;leukemia treatment;Leukemic Cell;Malignant Childhood Neoplasm;Mediating;Molecular;Mutation;new therapeutic target;Not Hispanic or Latino;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;overexpression;Pathway interactions;patient derived xenograft model;pediatric patients;Pharmaceutical Preparations;Pharmacotherapy;Phosphorylation;Phosphotransferases;Population;Pre-Clinical Model;precision medicine;Prognosis;Publishing;Reduce health disparities;Regulation;Relapse;Repression;Resistance;resistance mechanism;restoration;Role;Signal Pathway;Socioeconomic Factors;Testing;Therapeutic Effect;thiopurine;thiopurine methyltransferase;Transcription Repressor;Transcriptional Regulation;Treatment Efficacy;Tumor Suppressor Proteins

PROJECT_TITLE: Novel targeted therapy to reduce health disparities in pediatric leukemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This proposal will explore the human stem cell model previously generated by our group for the incurable motor neuron disease: spinal and bulbar muscular atrophy (SBMA). This work will elucidate the transcriptional regulation involved this disease in a human backgroung. The results generated by this study will have direct implications for therapy development in SBMA, and broadly, it will contribute to a new understanding of how skeletal muscle and motor neurons interact to produce neuromuscular diseases.

PI_NAMEs: MIRANDA, HELEN C (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Address;Adult;Affect;Androgen Receptor;Androgens;Animal Model;AR gene;Atrophic;Award;Biological Assay;Cell Death;cell type;Cells;Central Nervous System;ChIP-seq;chromatin immunoprecipitation;comparison control;Consensus;CRISPR interference;Data;Data Set;deep sequencing;defined contribution;differential expression;Disease;disease model;Etiology;experience;Family;Fertility;functional genomics;Gene Expression;gene repression;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Glutamine;Goals;Grant;Gynecomastia;Hi-C;Human;human stem cells;Huntington Disease;In Vitro;induced pluripotent stem cell;Inherited;International;Journals;Kennedy Syndrome;Letters;Ligands;Link;Literature;Luciferases;Manuscripts;member;Mentors;Mentorship;Mitochondria;Molecular;motor control;motor neuron degeneration;Motor Neuron Disease;Motor Neurons;Muscle;Muscle Weakness;mutant;Mutation;Nervous System Disorder;Neurodegenerative Disorders;Neuromuscular Diseases;Neuronal Dysfunction;Neurosciences;overexpression;Pathogenesis;Pathology;Pathway interactions;Patients;Phenotype;polyglutamine;professor;programs;Quantitative Reverse Transcriptase PCR;Reporter Genes;Research;responsible research conduct;Scientist;Skeletal Muscle;skeletal muscle wasting;Specific qualifier value;spinal and bulbar muscular atrophy;Stanolone;stem cell biology;stem cell model;stem cells;symposium;Testing;theories;Therapeutic;therapy development;Time;Tissues;tool;Toxic effect;Training;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Universities;Validation;Work

PROJECT_TITLE: Study of SBMA mutant AR transcriptional network in stem cell-derived motor neurons and skeletal muscle


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: PORTLAND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative  The signaling molecule ubiquitin controls many aspects of human biology. Despite its importance in numerous human diseases, the intricacies of how and where ubiquitin serves a signaling role are unknown. We study the means through which disease-causing bacteria hijack the ubiquitin signal as an approach to understanding its function in regulating human health.

PI_NAMEs: PRUNEDA, JONATHAN N (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Bacteria;Bacterial Infections;Bacterial Interference;Biochemical;Biology;Case Study;Cell Cycle Regulation;Cell Physiology;Disease;Enzymes;Feeds;Health;Human;Human Biology;human disease;innovation;Invaded;Life;Motivation;novel;Outcome;pathogenic bacteria;Play;Polymers;pressure;Process;protein degradation;Proteins;Regulation;Research;Role;Signal Transduction;Signaling Molecule;Specificity;stem;System;tool;Ubiquitin;Ubiquitination;Vision;Work

PROJECT_TITLE: Exploiting bacterial effector proteins to study human ubiquitin signaling


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DETROIT

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Patients around the world underscore the fear, challenges, and toll accompanying diabetic retinopathy, a major progressive blinding disease. The proposed studies will advance our knowledge in explaining how diabetic retinopathy progresses to a later stage of neovascularization through the metabolic adaptation of the Warburg effect. Aligned with the mission of the National Eye Institute to prevent diabetes-related blindness, this project holds great promise in providing a new strategy, through the use of inhibitors of the Warburg effect, for preventing and/or treating diabetic retinopathy.

PI_NAMEs: IBRAHIM, AHMED S (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acceleration;Aging;angiogenesis;Angiogenic Switch;Animals;Benchmarking;bevacizumab;Bioenergetics;Bioinformatics;Blindness;Blood Vessels;cancer cell;Cell Proliferation;Cells;Cellular Metabolic Process;Complication;conditional knockout;CRISPR/Cas technology;Data;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Retinopathy;Disease;Dose;Endoplasmic Reticulum;endoplasmic reticulum stress;Endothelial Cells;Endothelium;Enzymes;Extravasation;Fright;Functional disorder;Gene Expression;Glucose;Glycolysis;Goals;Human;Hyperglycemia;Hypoxia;Hypoxia Inducible Factor;in vitro Model;in vivo;inhibitor;Inositol;insight;Knockout Mice;Knowledge;Lasers;Lipids;Mediating;Mediator;Metabolic;Metabolism;Mission;Mitochondria;mitochondrial dysfunction;Modeling;National Eye Institute;neovascularization;Neuroglia;Neurons;neurovascular;neurovascular unit;novel;nucleotide metabolism;Oxidative Phosphorylation;Oxygen;Pathology;Pathway Analysis;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphotransferases;prevent;Production;proliferative diabetic retinopathy;Protein Biosynthesis;Proteins;Research Personnel;response;Retina;Retinal Neovascularization;Ribonucleases;Risk Factors;Role;Sampling;sensor;Signal Transduction;Streptozocin;success;Testing;Tissues;Tube;Visual Acuity;Warburg Effect

PROJECT_TITLE: The Warburg Effect and Diabetic Retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Diabetes;Genetics;Human Genome;Neurosciences;Nutrition;Obesity;Physical Activity;Sleep Research

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE: The widespread incidence of metabolic disease, including obesity and type 2 diabetes mellitus, has emerged as a worldwide public health challenge. Accumulating evidence suggests that susceptibility to these disorders is increased in people who disrupt their daily sleep/wake fasting/feeding cycles, as is often the case for shift or night workers. To advance our understanding of the link between circadian rhythms and metabolism, I propose to pinpoint the molecular mechanisms underlying our recently characterized circadian clock-HIF interaction in skeletal muscle tissue, and to characterize the role of this interaction in muscle exercise physiology and diet- induced obesity-associated insulin resistance. The overarching goal of this proposal is to understand the molecular mechanisms underlying circadian timing of metabolism and to advance our knowledge of metabolic disease.

PI_NAMEs: PEEK, CLARA BIEN (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Ablation;Acute;Address;Affect;anaerobic glycolysis;Animal Model;Animals;ARNTL gene;ATAC-seq;blood glucose regulation;Cardiometabolic Disease;Cells;ChIP-seq;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Collection;Contracts;Coupling;Darkness;Data;Diet;diet and exercise;diet-induced obesity;Disease;Disease Resistance;Energy consumption;Epidemiology;Exercise;Exercise Physiology;Exposure to;Fasting;feeding;Feeding behaviors;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Glucose;glucose disposal;glucose metabolism;Glycolysis;Goals;HIF1A gene;Hour;Human;Hypoxia;Hypoxia Inducible Factor;Hypoxia-Inducible Factor Pathway;Impairment;In Vitro;in vivo;Incidence;innovation;insight;Insulin Resistance;Isotope Labeling;Knockout Mice;Knowledge;Light;Link;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;Modeling;Molecular;molecular clock;Mus;Muscle;Muscle Fibers;Mutant Strains Mice;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Obesity;Pathway interactions;Periodicity;Persons;Physiological;Predisposition;Process;Production;Public Health;Publishing;Respiration;response;Rest;RNA;Role;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Sleep;Sleep Wake Cycle;Stimulus;Strenuous Exercise;Stress;Techniques;Testing;Time;Tissues;transcription factor;uptake;Variant;Work

PROJECT_TITLE: Clock Control of Muscle Glucose Metabolism and HIF Activity

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: SILVER SPRING

ORG_NAME: CENTER FOR CONSTRUCTION RES AND TRAINING

ORG_STATE: MD

PHR: Project Narrative The relevance of this proposal is to mitigate the hazards posed by hazardous waste and other hazardous material releases to the environment and public by training the construction workforce to perform clean-up and emergency response operations in a safe and productive manner. A well trained construction workforce enables EPA, DHS and other local, state and federal agencies to not only protect the workers themselves, but to also protect the environment and public from hazardous waste and materials, and to respond to disasters whether they are man-made or natural.

PI_NAMEs: CAIN, CHRISTINA TRAHAN (contact)

PROGRAM_OFFICER_NAME: BEARD, SHARON

PROJECT_TITLE: Hazardous Materials Worker Health and Safety Training


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE/RELEVANCE BRCA mutations confer an over 70% lifetime risk for breast cancer and the approval of several poly (ADP-ribose) polymerase (PARP) inhibitors have brought new hope for patients with homologous recombination repair deficient (HRD), including BRCA1/2-mutated breast, ovarian, prostate and pancreatic cancers. The combination of epigenetic modulators, such as DNA methyltransferase inhibitors, with PARP inhibitors may help the considerable number of patients who are or become refractory to these agents by exploiting the DNA vulnerability of BRCA and other HRD-mutated tumors.

PI_NAMEs: MUNSTER, PAMELA N. (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Acceleration;Aftercare;Alternative Therapies;Back;Biological Markers;Biological Models;Biopsy;Biopsy Specimen;Blood;Blood specimen;brca gene;BRCA mutations;BRCA1 gene;BRCA2 gene;Breast;Breast Cancer Risk Factor;Cancer cell line;cancer subtypes;Cancer Therapy Evaluation Program;Cell Line;cell type;Cells;CHEK2 gene;chemotherapy;Clinic;Clinical;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Combination immunotherapy;Combined Modality Therapy;Communities;Companions;comparative;Complex;Correlative Study;Data;Decitabine;DNA;DNA Damage;DNA methyltransferase inhibition;DNA Methyltransferase Inhibitor;DNA Modification Methylases;DNA Repair;DNA Repair Inhibition;DNA Repair Pathway;DNA Single Strand Break;Dose;Drug Combinations;Engineering;Epigenetic Process;Ethnic Origin;follow-up;functional status;Gene Mutation;Genes;Genetic;Genetic Engineering;Genomics;Hereditary Malignant Neoplasm;homologous recombination;homologous recombination deficiency;improved;In Vitro;in vivo;in vivo Model;Individual;Inherited;insight;interest;Laboratories;lifetime risk;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Modeling;Molecular;Mutate;Mutation;Organoids;participant enrollment;Pathway interactions;patient derived xenograft model;patient population;patient response;Patient Selection;Patient-derived xenograft models of breast cancer;Patients;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;phase I trial;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;predictive marker;Race;Randomized;recombinational repair;Refractory;Regimen;repair function;repaired;Resistance;resistance mechanism;response;Risk;Role;Sampling;screening;side effect;Source;synergism;Testing;Therapeutic;therapeutic target;therapy resistant;Tissues;Toxic effect;Translating;treatment response;tumor;tumor DNA;tumor progression;tumor xenograft;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Integrating Epigenetic Modulation into DNA Damage Repair

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Prevention

PI_NAMEs: GUSTAFSON, GARY  (contact)

PROJECT_TERMS: Abate;Air;Ally;apprenticeship;arm;Asbestos;Canada;Cementation;chemical disaster;Communities;Confined Spaces;Containment;Country;Development;Educational Curriculum;Effectiveness;Emergency response;Engineering;Ensure;Environment;Evaluation;Evaluation Reports;Excision;experience;Exposure to;follow-up;Funding Opportunities;Generations;hazard;Hazardous Substances;Hazardous Waste;Health;health training;Hour;Industry;Infection Control;instructor;International;Interview;Iron;Knowledge;Lead;Metals;model development;Monitor;National Institute for Occupational Safety and Health;North America;operation;Outcome;Patient Self-Report;Plumbing;prevent;programs;Research;respiratory;response;restoration;Risk;Risk Assessment;Safety;scaffold;Site;social media;Students;success;Surveys;Target Populations;Teacher Professional Development;Technology;Trade Unions;Trainers Training;Training;Training and Education;Training Programs;Transportation;U-Series Cooperative Agreements;union lists;United States;Veterans;Work

PROJECT_TITLE: Hazardous Waste Worker Training Program


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: SURTEES, STEVE  (contact)

PROJECT_TERMS: apprenticeship;arm;Behavior;Boston;career;career preparation;Communities;community organizations;Complement;Containment;Contractor;Country;Disparity;Disparity population;Economics;Effectiveness;Emergency response;Employment;empowerment;Ensure;Environment;Environmental Hazards;Evaluation;Excision;Funding;Funding Opportunities;Generations;Goals;Hazardous Substances;Hazardous Waste;Health;high risk;Hour;Impact evaluation;improved;Individual;Industry;Injury;innovation;Institution;International;Learning;Letters;Life;Longevity;Low income;Mentors;Michigan;Minnesota;Minority;minority communities;model development;Modeling;National Institute of Environmental Health Sciences;Nonprofit Organizations;North America;occupational health/safety;Occupations;Outcome;Participant;Pathway Analysis;Pathway interactions;Process;programs;recruit;remediation;Research;response;Safety;Services;Site;skills;skills training;Social Network;Students;success;Toxicant exposure;Trade Unions;Training;Training Programs;Transportation;U-Series Cooperative Agreements;Underserved Population;Unemployment;union lists;Vocational Guidance;Vulnerable Populations;Work;Workplace

PROJECT_TITLE: Environmental Career Worker Training Program


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Hematology;Infectious Diseases;Sepsis

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE – PUBLIC HEALTH RELEVANCE Vancomycin-resistant enterococci (VRE) are one of the most important hospital-associated, multidrug- resistant organisms affecting critically ill patients and are considered a major public health threat by the WHO and CDC. Treatment of VRE bloodstream infections poses immense therapeutic dilemmas in clinical settings due to the lack of reliable antibiotic options, making these infections untreatable in certain scenarios. Using a contemporary prospective cohort of patients with enterococcal bacteremia, this proposal seeks to provide a robust characterization of the clinical impact of VRE bloodstream infections, deliver epidemiological insights into the genomic characteristics of infecting isolates and develop innovative approaches to optimize the diagnosis and treatment of these organisms causing recalcitrant infections in vulnerable patients.

PI_NAMEs: ARIAS, CESAR AUGUSTO (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Affect;Ampicillin;Antibiotics;antimicrobial;appropriate dose;Bacteremia;bactericide;beta-Lactams;Biological;biological adaptation to stress;Blood;Cell membrane;Cell surface;Cessation of life;Characteristics;Cities;Clinical;clinical practice;cohort;comorbidity;Critical Illness;Daptomycin;Data;design;Detection;Diagnosis;Diagnostic;diagnostic strategy;Diagnostic tests;Disease;DNA Sequence Rearrangement;drug resistant microorganism;Enterococcus;Enterococcus faecium;Epidemiology;Europe;Evolution;Extracellular Protein;Failure;FDA approved;Future;Genes;Genetic;Genetic Heterogeneity;Genome;genomic variation;Genomics;Geographic Locations;Hematologic Neoplasms;Hospitals;Immune system;Immunocompromised Host;improved;improved outcome;In Vitro;Individual;Infection;innovation;insight;Intervention Studies;Knowledge;Life;Linezolid;Location;Mediating;Methods;minimal inhibitory concentration;mortality;Multi-Drug Resistance;multi-drug resistant pathogen;Multivariate Analysis;Mutation;novel;novel diagnostics;novel strategies;novel therapeutics;organ transplant recipient;Organism;Outcome;Outcome Study;pathogen;Patient-Focused Outcomes;Patients;Performance;Population;Population Dynamics;Predisposition;prospective;Prospective cohort;Prospective Studies;Public Health;public health relevance;recruit;Recurrence;Reproducibility;Resistance;Resistance development;response;Safety;Sepsis;Solid;South America;Structure;Survival Analysis;System;Testing;Therapeutic;tool;translational study;treatment optimization;Treatment Protocols;Uncertainty;Vacuum;Vancomycin resistant enterococcus;Venous;virtual;Vulnerable Populations

PROJECT_TITLE: VENOUS: A translational study of enterococcal bacteremia

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


PI_NAMEs: KASSMAN, MICHAEL  (contact)

PROJECT_TERMS: Applications Grants;apprenticeship;Area;arm;community organizations;Containment;Data Collection;Disasters;Education and Outreach;Emergency response;empowerment;Ensure;Excision;first responder;Funding;Funding Opportunities;Generations;Goals;Grant;hazardous materials disaster;Hazardous Substances;Hazardous Waste;Health;Hour;improved;Industrialization;Industry;Injury;Institution;instructor;International;man-made disasters;metropolitan;model development;National Institute of Environmental Health Sciences;Nonprofit Organizations;North America;occupational health/safety;Occupations;operation;outreach;Private Sector;Program Appropriateness;programs;Qualifying;Readiness;Recovery;Registries;Request for Applications;Research;Resources;response;Safety;Services;skills;skills training;Students;success;synergism;System;Terrorism;Trade Unions;Trainers Training;Training;Training and Education;Training Programs;Training Support;Transportation;U-Series Cooperative Agreements;union lists;Work

PROJECT_TITLE: Hazmat Disaster Preparedness Training Program


NIH_SPENDING_CATS: Neurosciences;Sleep Research

ORG_CITY: SEATTLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE  Central clocks within the brain regulate 24-h rhythmicity including the sleep-wake cycle. Although the intracellular molecular mechanisms by which these clocks operate are well characterized, little is known about how their neurons interact to generate coordinated and robust 24-h signals. In this proposal, we test the hypothesis that part of the essential mechanisms by which these neurons interact is a 24-h change in the structure of synaptic contacts between neurons.

PI_NAMEs: CERIANI, MARIA FERNANDA;DE LA IGLESIA, HORACIO O (contact);ELLISMAN, MARK H

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Adult;Animals;Argentina;ARNTL gene;Astrocytes;Automobile Driving;Behavior;Behavioral;Biological Models;Brain;Calcium;Cell Communication;Cells;circadian;circadian pacemaker;Circadian Rhythms;Confocal Microscopy;Country;Coupled;Cues;density;Dependovirus;Drosophila genus;Electron Microscopy;Enterobacteria phage P1 Cre recombinase;ex vivo imaging;experience;experimental study;Face;Feedback;Fiber;Flavoproteins;fly;gene product;Genetic;Genetic Transcription;Hypothalamic structure;immunocytochemistry;Immunohistochemistry;Impairment;Injections;knock-down;Label;light microscopy;longitudinal analysis;M cell;Mammals;Mediating;Molecular;Motor Activity;mouse Cre recombinase;Mus;Neurites;Neuroglia;neuronal circuitry;Neurons;Neuropeptides;Neurotransmitters;Organism;Pacemakers;Periodicity;Photoperiod;Physiological;Pigments;polymerization;Polymers;Postdoctoral Fellow;postsynaptic;presynaptic;Principal Investigator;Process;promoter;Property;receptor;reconstitution;recruit;Reporter;Reporting;Research;response;Satellite Viruses;Scanning Electron Microscopy;Seasons;Signal Transduction;Sleep Wake Cycle;Slice;Structure;Students;suprachiasmatic nucleus;Synapses;Synaptophysin;System;Techniques;Testing;Time;tissue fixing;tool;Training;Translations;Vasoactive Intestinal Peptide;vector;Viral;Visualization

PROJECT_TITLE: Circadian Structural Plasticity in Central Pacemakers


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: RELEVANCE: Cell cycle deregulation is the fundamental foundation of cancer, and understanding how this occurs and can be therapeutically targeted is of clinical significance. Here we will explore how the RB- pathway and cell cycle states can be exploited therapeutically either as a mechanism using models of triple negative breast cancer.

PI_NAMEs: KNUDSEN, ERIK  (contact);WITKIEWICZ, AGNIESZKA

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Ablation;Automobile Driving;Biochemical;Biological;Breast Cancer cell line;cancer cell;Cancer cell line;Cancer Model;CCNE1 gene;CDK4 gene;Cell Cycle;Cell Cycle Deregulation;Cell Cycle Progression;Cell Cycle Regulation;Cells;Clinic;clinically relevant;clinically significant;Complex;Computer Models;Coupled;Cyclin D1;Cyclins;Data;Dependence;Disparate;Event;Evolution;FDA approved;Foundations;G1 Phase;Gene Expression;Genes;Heterogeneity;in vivo;inhibitor;Intervention;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;Mammalian Cell;Modeling;Molecular;Nature;novel strategies;oncogene addiction;Oncogenes;Oncogenic;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;Play;Primary Neoplasm;Process;Proliferating;Resistance;response;Role;Signal Transduction;Specimen;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;Tissues;tool;triple-negative invasive breast carcinoma;tumor;Tumor Tissue;tumorigenic;Work;Xenograft procedure

PROJECT_TITLE: Delineating the dystopian nature of the cell cycle in cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Lung;Neurosciences;Physical Rehabilitation;Rehabilitation;Sleep Research;Stroke

ORG_CITY: SYRACUSE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative Sleep is critical for health and quality of life; however, little is known about the prevalence or impact of non- obstructive sleep apnea (non-OSA) sleep disorders in people with stroke. The proposed study aims to characterize the proportion of people with stroke that have non-OSA sleep disorders and their impact on recovery of activities of daily living, functional mobility, and participation along the continuum of recovery in people with stroke.

PI_NAMEs: KLINGMAN, KAREN J (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: actigraphy;Activities of Daily Living;Age;Big Data Methods;Chronic;Circadian Rhythm Disorder;Clinic;cognitive disability;Complement;Complex;Data;Data Analyses;Development;Diagnosis;Drowsiness;Exhibits;experience;Foundations;Frequencies;General Population;Global Positioning System;Goals;Health;Hypersomnias;improved;indexing;Individual;innovation;Intervention;Knowledge;Learning;Measurement;Measures;Medicine;Monitor;Mood Disorders;motor learning;motor skill learning;Motor Skills;Movement Disorders;Nature;Nonpharmacologic Therapy;Obstructive Sleep Apnea;Parasomnias;Participant;Patient Self-Report;Persons;pharmacologic;Physicians;Play;post stroke;Prevalence;Probability;Productivity;Quality of life;Questionnaires;Recommendation;Recovery;Recovery of Function;Recurrence;rehabilitation strategy;Rehabilitation therapy;Research;response;Restless Legs Syndrome;Risk Factors;Role;secondary analysis;Severities;Sleep;sleep abnormalities;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;Sleeplessness;Societies;Speed;Stroke;stroke recovery;stroke rehabilitation;Symptoms;Techniques;Testing;Time;tool;wearable sensor technology;Workplace

PROJECT_TITLE: The SLEEPR study: SLEep Effects on Post-stroke Rehabilitation

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Charcot-Marie-Tooth Disease;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Narrative This project will investigate the involvement of neuropilin 1 (Nrp1) cell signaling pathway in all tRNA synthetase-linked Charcot-Marie-Tooth disease (CMT) subtypes and uncover the role of extracellular tRNA synthetases in the normal cell signaling process.

PI_NAMEs: YANG, XIANG-LEI  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;Alleles;Amino Acids;Amino Acyl-tRNA Synthetases;Biological Process;Body System;Cell Culture Techniques;Cell Physiology;Cell Signaling Process;Cells;Charcot-Marie-Tooth Disease;Circulation;Culture Media;Cytosol;Disease;disorder subtype;Enzymes;extracellular;Extracellular Space;Family;Family member;Human;human disease;Link;Mus;mutant;Mutation;Neurodegenerative Disorders;Neuropilin-1;Normal Cell;Pathologic;Physiological;Protein Biosynthesis;Reaction;Role;Signal Pathway;Signal Transduction;Tooth Diseases;Transfer RNA Aminoacylation

PROJECT_TITLE: Link extracellular function of tRNA synthetase with pathological mechanism of disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Sleep Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative High blood pressure and blood pressure that does not decrease by at least 10% during sleep are both associated with cardiovascular disease and death. The overall objective of the proposed study is to determine specific sleep and circadian rhythm factors that contribute to high blood pressure during sleep. A better understanding of these factors will help us design specific interventions to lower blood pressure during sleep and reduce cardiovascular disease and death.

PI_NAMEs: THOMAS, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: TATAW-AYUKETAH, GLADYS OROCK

PROJECT_TERMS: Academic Medical Centers;actigraphy;Activities of Daily Living;Address;Age;age difference;Alabama;Ambulatory Blood Pressure Monitoring;Anti-Hypertensive Agents;awake;Behavior Therapy;Behavioral;Biological;Blood Pressure;blood pressure control;Blood Pressure Monitors;blood pressure reduction;Body Temperature;California;Cardiovascular Diseases;cardiovascular disorder risk;Cessation of life;Characteristics;Chronotherapy;circadian;Circadian Rhythms;Clinical;Clinical Sciences;cohort;Data;design;Detection;Development;Educational workshop;Ethnic Origin;feeding;Future;Home Blood Pressure Monitoring;Hour;Human;Hypertension;improved;Intervention;Jet Lag Syndrome;Light;Los Angeles;Low Prevalence;Measurement;Melatonin;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;New York;Organ;Participant;participant enrollment;Pattern;Persons;Pharmaceutical Preparations;Phase;Phenotype;Play;Population;Population Sciences;Posture;precision medicine;Prevalence;prevent;primary outcome;Protocols documentation;Questionnaires;Race;Research;Role;Salivary;Sampling;secondary outcome;sex;shift work;Site;Sleep;sleep behavior;Sleep Fragmentations;social;Strategic Planning;System;therapy development;Time;Universities;Wrist

PROJECT_TITLE: Sleep and Circadian Contributions to Nighttime Blood Pressure Rhythms (SCN-BP)

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Dissemination and Implementation Research;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Sepsis

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The proposed project is making use of Internet of Things (IoT) sensors and computers to collect and analyze data from hospitalized patients with sepsis. We plan to develop methods to identify patterns in the patient data which predict who is at risk for deterioration and which treatments they may benefit. We have a very strong team of doctors and researchers who work closely together, covering all aspects of the proposed research, which we hope will help us improve the care of hospitalized patients with sepsis.

PI_NAMEs: NEMATI, SHAMIM  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;advanced analytics;Algorithms;analytical tool;Antibiotics;Blood Pressure;Blood Vessels;Caregivers;Caring;Cessation of life;Clinical;Clinical Data;Clinical Research;Collaborations;Computers;Data;data integration;Data Sources;data-driven model;Death Rate;Deterioration;Development;Devices;Dialysis procedure;Dissemination and Implementation;Education;Electronic Health Record;Ensure;Fast Healthcare Interoperability Resources;Healthcare Systems;Hospitalization;Hospitals;Hour;Hypotension;implementation barriers;implementation study;improved;Infection;Inflammation;Injury to Kidney;Inpatients;insight;Internet of Things;interoperability;K-Series Research Career Programs;Life;Liquid substance;Liver;Lung;Machine Learning;Medical;Methods;Monitor;multi-task learning;next generation;organ injury;Outcome;Patient Care;Patients;Pattern;personalized therapeutic;Pharmaceutical Preparations;Phenotype;portability;Predictive Analytics;Prevention;programs;Pump;Research;Research Personnel;Resolution;Resources;response;Risk;Risk Estimate;sensor;Sepsis;Septic Shock;Syndrome;Therapeutic Intervention;Time;usability;Validation;Vasoconstrictor Agents;Ventilator;wearable device;wearable monitor;wearable sensor technology;Work

PROJECT_TITLE: GeneRAlizable Sepsis Phenotyping (GRASP) using Electronic Health Records and Continuous Monitoring Sensors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative: DNA packaging into open euchromatin and more compacted heterochromatin is essential for normal development and this packaging is disrupted in disease. Our research aims to define mechanisms that control heterochromatic compaction during embryogenesis and to understand the requirements for this compaction in regulating early transcription. Understanding the mechanisms that drive heterochromatin establishment in normal development is a critical first step toward designing approaches to restore appropriate DNA packaging to diseased tissues, while defining requirements for heterochromatin in the early embryo will elucidate the relationship between genome organization and the emergence of gene expression programs that control development.

PI_NAMEs: GOLL, MARY GRACE (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TITLE: Heterochromatin in the developing vertebrate embryo


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Stroke

ORG_CITY: LOS ANGELES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Stability of intracranial aneurysms is affected by local hemodynamic flow stress, which can trigger growing and rupture, resulting in severe morbidity and high mortality. The goal of this project is to characterize the endothelial signaling pathways induced by abnormal flow stress in intracranial aneurysms, and cellular mechanisms which contributes to unstable wall remodeling at high risk for rupture. The knowledge gained in this project will be fundamental to the development of accurate and reliable prediction tools or drug treatments for unruptured intracranial aneurysms.

PI_NAMEs: KANEKO, NAOKI  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3-Dimensional;3D Print;Abnormal Endothelial Cell;Address;Affect;Aneurysm;Angiography;Animal Model;Area;Biological;Biological Markers;Bulla;Cell Shape;Cellular Morphology;cerebrovascular;Characteristics;Clinical;clinical database;clinical imaging;Collaborations;Complex;Data;data integration;Data Set;Databases;Development;Diagnostic Imaging;Endothelial Cells;Endothelium;Exhibits;follow-up;Functional disorder;Gene Expression;Goals;Growth;Harvest;hemodynamics;high risk;histological image;Human;human imaging;Image;In Vitro;in vitro Model;Inflammation;innovation;Intracranial Aneurysm;Investigation;Knowledge;Link;Liquid substance;Maps;Mediating;Medical;Methods;microCT;Microscopic;Microscopy;Microsurgery;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;multi-photon;multidisciplinary;multimodality;multiphoton microscopy;novel;Operative Surgical Procedures;Pathologic;Patients;Permeability;pharmacologic;Pharmacotherapy;precision medicine;predictive tools;Prevention;radiological imaging;Regulation;Reporting;Research;response;Risk;Risk Factors;risk prediction;Role;Rupture;Ruptured Aneurysm;Sampling;Scanning;Signal Pathway;Signal Transduction;simulation;Source;Spatial Distribution;Specific qualifier value;Stress;stressor;Subarachnoid Hemorrhage;Surgical Clips;System;Techniques;Technology;Testing;Thinness;Time;Tissue Sample;Tissues;translational therapeutics;Unnecessary Surgery;Vascular Endothelial Cell

PROJECT_TITLE: Bridging the Gap from Hemodynamic Stress to Intracranial Aneurysm Instability: An Integrated Multimodal Approach

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Childhood Obesity;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Nutrition;Obesity;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: DENTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEXAS WOMAN'S UNIVERSITY

PHR: Project Narrative The current proposal seeks to determine if neuroepigenetic mechanisms are involved in the pathophysiology of obesity. The aims of this proposal will be addressed using a recently developed animal model of obesity and will combine molecular biology and behavioral techniques. The results generated from this research will yield significant insight into putative molecular mechanisms involved in the etiology of obesity and will provide potential therapeutic targets with which to treat those individuals suffering from obesity.

PI_NAMEs: NA, ELISA S (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Address;Adult;Affect;Animal Model;Award;Behavioral;behavioral response;Body Weight;Body Weight decreased;Calories;Cardiovascular Diseases;Child;Chronic;Classification;Clinical Data;combat;Data;Desire for food;Diabetes Mellitus;Diagnosis;Disease;Eating;effective therapy;Electrophysiology (science);Epidemic;Epigenetic Process;Etiology;Failure;Fatty acid glycerol esters;Food;food quality;Functional disorder;gain of function mutation;Goals;Grant;Healthcare;hedonic;High Fat Diet;Homeostasis;Hyperphagia;Hypertension;Hypothalamic structure;Individual;insight;Kidney Diseases;knock-down;Knock-out;Knockout Mice;Leptin;Liver diseases;loss of function mutation;male;Malignant Neoplasms;MeCP2 Duplication Syndrome;Mediating;Metabolism;Methyl-CpG-Binding Protein 2;Mind;Molecular;Molecular Biology;Morbid Obesity;mouse model;Mus;Mutation;neurobiological mechanism;Neurobiology;Neurodevelopmental Disorder;Neurologic;neuronal excitability;Neurons;Obesity;obesity development;Obesity Epidemic;Overweight;Persons;Phenotype;Play;Prader-Willi Syndrome;preference;Prevalence;Pro-Opiomelanocortin;Process;Productivity;Property;Prosencephalon;Recurrent disease;Research;Rett Syndrome;reward processing;Rewards;Risk Factors;Role;Secure;Signal Pathway;Signal Transduction;statistics;Syndrome;Techniques;Therapeutic;therapeutic target;Transgenic Mice;treatment strategy;Underweight;Weight Gain;World Health Organization

PROJECT_TITLE: Elucidating the role of MeCP2 in the pathophysiology of obesity


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome;Prevention

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Antibiotic-resistant microbial pathogens are a grave and urgent threat to public health. With rising rates of drug- resistant infections and a diminishing arsenal of new antibiotic treatments, there is pressing need for approaches to better understand, predict, and prevent the emergence of antibiotic resistance, particularly in the human gut microbiome, which is an important source of antibiotic resistances. We are developing an automated, high-throughput technology that can reproduce key features of the human gut ecosystem, and enable us to evolve antibiotic resistance in pathogenic bacteria directly in the laboratory to understand how resistance emerges.

PI_NAMEs: KHALIL, AHMAD SAMIR (contact);RAKOFF-NAHOUM, SETH

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Address;Aerobic;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Atmosphere;atmospheric conditions;Automation;Automobile Driving;bacterial community;Bioreactors;Clinical;Communities;Complex;cost;cost effective;Drug resistance;Ecology;Ecosystem;emerging antibiotic resistance;emerging antimicrobial resistance;Environment;Escherichia coli;Evolution;experimental study;Feedback;fitness;Gases;Genetic;genetic approach;genetic element;global health;Growth;gut microbes;gut microbiome;gut microbiota;high throughput technology;Human;Human Microbiome;in vivo;Individual;Infection;instrument;Laboratories;Life;Maps;member;metagenomic sequencing;Microbe;microbial;Microbial Antibiotic Resistance;microbiome research;multi-drug resistant pathogen;Mutation;Nature;novel;open source;Organism;Outcome;Oxygen;pathogen;pathogenic bacteria;pathogenic microbe;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Population;Population Genetics;Predisposition;prevent;Prevention strategy;Probiotics;Public Health;Research;Research Personnel;Resistance;resistance mutation;Role;Sampling;Schedule;Scheme;Site;Source;success;System;Technology;Time;tool;treatment strategy;Work

PROJECT_TITLE: Programmable benchtop bioreactors for scalable eco-evolutionary dynamics of the human microbiome

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: FD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE The California Animal Health and Food Safety (CAHFS) system is comprised of four branch laboratories dedicated to veterinary diagnostics with a diagnostic mission that includes testing samples from animals, the environment and food destined for human consumption. The CAHFS system is uniquely qualified to assist with the Veterinary Laboratory Investigation Response Network (Vet-LIRN) mission by providing technical expertise with surge capacity, reliable performance of established procedures and diagnostic acumen.

PI_NAMEs: KURTH, KATHY LYNN (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: CAHFS Microbiology VetLIRN support


ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

PHR: Ending Veteran homelessness remains a major federal priority. The US Department of Housing and Urban Development-Veterans Affairs Supportive Housing (HUD-VASH) program is the largest supported housing program for homeless Veterans. Before COVID-19, HUD-VASH case management was provided in-person. During the pandemic, case management shifted to virtual care. The pandemic provides an opportunity for the first time to examine changes, both positive and negative, associated with virtual care in the HUD-VASH program nationally. A mixed methods design will be used to: 1) Determine the effect of HUD-VASH’s shift to virtual care during the COVID-19 pandemic on case management services; 2) Evaluate the effect of HUD- VASH’s shift to virtual care during the pandemic on Veteran’s health care utilization and continuity of care; and 3) Examine Veteran and provider experiences with virtual case management in HUD-VASH. The results will inform the future use of virtual care in HUD-VASH and help prepare for the next public health emergency.

PI_NAMEs: JUTKOWITZ, ERIC  (contact);TSAI, JACK

PROJECT_TERMS: Address;Adopted;Alcohol abuse;Ambulatory Care;Behavioral;behavioral health;Caring;Case Management;Case Manager;clinical care;Clinical Services;Communities;Complex;Continuity of Patient Care;COVID-19;COVID-19 impact;COVID-19 pandemic;Data;data warehouse;Dedications;design;Diagnosis;Enrollment;Ensure;Evaluation;evidence base;Evolution;experience;follow-up;Future;Goals;Health;health care service utilization;Health Services Accessibility;Healthcare;Home;Homelessness;Hospitalization;Housing;implementation facilitators;improved;inpatient psychiatric treatment;Interruption;Interview;Investments;Joints;Leadership;Link;Measures;Medical;Medical center;Mental Health;Methodology;Methods;Modeling;operation;Opioid Analgesics;opioid use disorder;Outcome;Outpatients;outreach;pandemic disease;pandemic disruption;Persons;Pharmaceutical Preparations;Policies;Poverty;pre-pandemic;Primary Care;programs;Provider;public health emergency;response;Risk;secondary analysis;Series;Services;social health determinants;Specialist;Structure;Suicide;supported housing;System;Systems Analysis;Telephone;theories;Time;U.S. Department of Housing and Urban Development;United States Department of Veterans Affairs;Veterans;virtual;virtual healthcare

PROJECT_TITLE: Evaluating the Impact of COVID-19 on Case Management, Health Care Utilization, and Housing Outcomes for HUD-VASH Veterans

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

PHR: Project Narrative  A key component of success for most viruses is the antagonisim of the production of interferons, potent signaling proteins that drive the induction of an antiviral state. Critically, viruses must maintain this antagonism throughout all members of the the population, as detection of any single viral particle and subsequent interferon production endangers them all. This proposal seeks to understand how this difficult challenge is achieved by influenza A virus in the face of highly promiscuous replication machinery, in the hopes that such an understanding may provide insight into novel therapeutic targets as well as an improved understanding of viral evolution.

PI_NAMEs: RUSSELL, ALISTAIR B (contact)

PROJECT_TERMS: acute infection;Address;antagonist;Cells;Cessation of life;Data;Defect;Detection;Disease;Evolution;Failure;Genomic Segment;high risk;Human;Immune;improved;Individual;Influenza;Influenza A virus;insight;Interferons;Life Cycle Stages;Ligands;member;Modeling;Molecular Virology;mutation screening;Natural Immunity;new therapeutic target;novel therapeutics;Oncolytic;particle;pathogen;pathogenic virus;Pathology;Pathway interactions;Polymerase;Population;pressure;Production;Property;respiratory infection virus;response;Rest;Route;Signaling Protein;Structure;success;Therapeutic;vaccine candidate;Variant;Viral;viral detection;Virion;Virus;Virus Diseases

PROJECT_TITLE: Understanding evasion of cell intrinsic innate immunity in viral populations with high rates of replicative failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)R]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE Heart disease remains the leading cause of death and disability in the western world. This proposed renewal training grant application will again focus on this theme, and our collective 18 faculty members have made this their life’s work. The program will train the highest quality of young scientists in cardiovascular research, who will be the future leaders in developing better therapy and treatment for this devastating condition.

PI_NAMEs: KRANIAS, EVANGELIA G;MOLKENTIN, JEFFERY D (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Cardiovascular Diseases

PROJECT_TITLE: Understanding Cardiovascular Disease Mechanisms

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Gene Therapy;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Age-related neurodegenerative disorders, such as Alzheimer’s disease and related tauopathies, are a major therapeutic challenge. Gene therapy shows great promise for treating neurological disorders; however, non- invasive, and brain-specific gene delivery remains a challenge. Our study seeks to optimize the application of combining transcranial focused ultrasound with intrathecal delivery of AAV vectors to treat the adult brain overall more effectively as well as to target disease-critical regions, determine mechanisms for this action, and validate this method for the treatment of tauopathies.

PI_NAMEs: BAILEY, RACHEL M (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: adeno-associated viral vector;adeno-associated virus 9 delivery;adenovirus mediated delivery;Adult;Affect;Age;age related neurodegeneration;Alzheimer's Disease;Animal Model;Animals;behavior test;Biochemical;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier disruption;Brain;brain parenchyma;Brain region;Capsid;Cells;Cephalic;Cerebrospinal Fluid;Clinical Treatment;Clinical Trials;cost;Coupled;cranium;Data;delivery vehicle;Dependovirus;Disease;Distal;Dose;Engineering;Etiology;Exposure to;Focused Ultrasound;Gene Delivery;gene therapy;Gene Transfer;gene-targeted therapy;Genetic Materials;Goals;Grant;Hepatotoxicity;hindbrain;Histopathology;Human;Immune response;Immunize;improved;Injections;Insertional Mutagenesis;Interphase Cell;Intervention;Intrathecal Injections;Intravenous;Kinetics;knock-down;manufacture;Mediating;Methods;MicroRNAs;mouse model;Mus;Nervous System Disorder;Neurodegenerative Disorders;Neurons;neutralizing antibody;novel;novel strategies;Outcome;particle;Pathogenesis;Pathologic;Procedures;promoter;Recombinant adeno-associated virus (rAAV);Research;Risk;Route;Safety;Serotyping;Site;Specificity;Spinal Cord;Spinal Ganglia;tau mutation;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutic gene;therapeutically effective;therapy outcome;Toxic effect;transduction efficiency;transgene expression;Translating;Trauma;Tropism;vector;Viral;Viral Vector;Weight;Work

PROJECT_TITLE: Gene Therapy Delivery for Age-related Neurodegenerative Diseases

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The proposed research is relevant to public health because a careful data-driven examination of the research domain criteria (RDoC) framework would provide the much-needed validation and potentially new data-driven hypotheses for fine-tuning. Further, by performing a secondary analysis of three large-scale cohorts, consisting of participants from the general population and patients, we aim to reveal how RDoC hierarchy is affected by age, diagnosis, and sex.

PI_NAMEs: SAGGAR, MANISH  (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: Address;Adolescent;Adult;Advocate;Affect;Age;Architecture;Attention;Behavior;Behavior assessment;Behavioral;Behavioral Paradigm;Biological;Bipolar Disorder;Brain;brain based;Child;Clinical;clinical translation;Cognitive;cognitive development;cohort;Communities;computer framework;connectome;Costs and Benefits;Data;Data Aggregation;Data Analyses;Data Analytics;Data Set;Development;Diagnosis;Diagnostic;Dimensions;Disease;disease classification;domain mapping;Effectiveness;efficacy research;functional MRI scan;General Population;Genes;Goals;Human;Hyperactivity;Individual Differences;insight;Instruction;large scale data;Maps;Measures;Methods;National Institute of Mental Health;Negative Valence;neuroimaging;Neuropsychology;Neurosciences;Participant;Pathway interactions;patient population;Patients;Population;Positive Valence;Psychopathology;Public Health;Research;Research Domain Criteria;Research Project Summaries;Rest;Sample Size;Sampling;Scanning;Schizophrenia;secondary analysis;sex;sex as a biological variable;Site;spatiotemporal;Structure;Syndrome;System;Task Performances;Translations;Validation;Vertebral column

PROJECT_TITLE: Examining the hierarchical structure of the RDoC framework using large-scale data-driven computational approaches


ADMINISTERING_IC: DC

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Neurosciences;Nutrition;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SANTA BARBARA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project narrative The mosquito disease vector, Aedes aegypti, is troubling because it spreads viruses that cause diseases such as dengue, yellow fever, and Zika, which infect >100,000,000 people/year. The identification of opsins as the first bitter taste receptor in mosquitoes offers the potential for identifying receptor antagonists to improve the efficacy of attractive toxic sugar baits, and reduce populations of insect disease vectors, and human disease. In addition, identifying mammalian opsins as the first receptor for the bitter compound, naringin, which is a common bitter ingredient in grapefruit and other fruit, provides the possibility of isolating antagonists for this receptor, to improve the palatability of many nutritious fruit that promote human health.

PI_NAMEs: MONTELL, CRAIG  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Aedes;Amino Acids;Animals;antagonist;Behavior;behavior test;Behavioral Assay;Biological Assay;Blood;Catechin;Cellular biology;Chemicals;chromophore;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Culicidae;Data;defined contribution;Dengue;Detection;detector;Development;Diet;dietary;Disease;Disease Vectors;Drosophila genus;egg;Electrophysiology (science);Esthesia;Evolution;experience;experimental study;Family;fascinate;feeding;Female;Flavonoids;fly;Fruit;G-Protein-Coupled Receptors;Genetic;genetic manipulation;Goals;Grapefruit;Health;Homologous Gene;Human;human disease;Image;Impairment;improved;In Vitro;in vitro Assay;in vivo;insect disease vector;Insecta;interest;Ligand Binding;Ligands;Light;male;Mammals;member;Modality;Modeling;Molecular Genetics;Motivation;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutation;Neurons;Nutrient;Nutritional;Opsin;Organ;Partner in relationship;Persons;Photoreceptors;Plants;Poison;Population;Production;Property;Proteins;receptor;Receptor Activation;Receptor Cell;response;Rhodopsin;Role;Specificity;sugar;Taste Buds;Taste Perception;Testing;Tongue;tool;transcriptome;transcriptome sequencing;Transgenic Organisms;vector;Vertebrate Photoreceptors;Virus;Visual System;Vitamin A;Work;Yellow Fever;ZIKA

PROJECT_TITLE: Opsins as a new class of evolutionarily conserved taste receptors

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: MEDICI, VALENTINA  (contact)

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Agriculture;Biological Sciences;career;career development;Center for Translational Science Activities;Clinical;Clinical Research;Clinical Sciences;college;Competence;Creativeness;Discipline of Nursing;Diverse Workforce;Educational Curriculum;Engineering;Environmental Science;experience;flexibility;Fostering;Foundations;Funding;Goals;Government;graduate student;Individual;Industry;Institution;interdisciplinary curriculum;Letters;Medical;medical schools;Medical Students;member;Mentors;National Research Service Awards;Pathway interactions;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Process;programs;Qualifying;Research;Research Personnel;Resources;Role;Science;Structure;Students;synergism;Time;TNFSF15 gene;Training;Translational Research;Veterinary Medicine

PROJECT_TITLE: NRSA Training Core (TL1)


ORG_CITY: RENO

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Project Narrative Overall Neurological impairments and disease are a major focus of healthcare, and understanding and treating these impairments is central to the mission of many institutes at NIH. The COBRE will support research infrastructure across multiple platforms that will help to characterize both the healthy brain and neural disorders, and will advance knowledge of the neural basis of behavior and cognition.

PI_NAMEs: WEBSTER, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Address;Area;arm;Award;base;Basic Science;Behavior;Biomedical Engineering;Brain;cellular imaging;Centers of Research Excellence;Clinical Research;Clinical Sciences;Cognition;Cognitive;Collaborations;Communities;computational neuroscience;Computer Analysis;Computer Models;Core Facility;cost;cost effective;Data;Data Analytics;deep learning;design;Development;Discipline;Disease;driving force;Extramural Activities;Faculty;Financial Support;Fostering;Functional Magnetic Resonance Imaging;Funding;Funding Agency;Goals;Growth;Healthcare;Impairment;Infrastructure;Institution;Knowledge;Machine Learning;Mentors;Mission;Modernization;Molecular;molecular imaging;neural;neuroimaging;Neurologic;Neurosciences;Neurosciences Research;Nevada;Output;Peer Review;Phase;Pilot Projects;Positioning Attribute;Productivity;programs;Publications;rapid growth;Research;research facility;Research Infrastructure;Research Personnel;Research Priority;Research Support;Resources;Scientific Advances and Accomplishments;Secure;Services;success;synergism;tenure track;Time;Training;Training Programs;undergraduate student;United States National Institutes of Health;Universities;Virtual and Augmented reality;virtual reality

PROJECT_TITLE: Center for Integrative Neuroscience


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PHR: Project Narrative Administrative Core The Administrative Core will coordinate and implement the overall management, evaluation, and strategic planning for all aspects of the center including the research cores and pilot project program.

PROJECT_TERMS: Address;Advisory Committees;Animals;Award;base;Biomedical Research;Budgets;Businesses;Centers of Research Excellence;cognitive neuroscience;Communication;Communities;Core Facility;cost effective;design;Employee;Ensure;Equipment;Equipment and supply inventories;Evaluation;Faculty;Fertilization;Funding;Goals;Grant;Human;Human Resources;Infrastructure;Institution;Knowledge;Lead;meetings;member;Methods;Mission;Modeling;National Institute of General Medical Sciences;neuroimaging;Neurosciences;Nevada;Phase;Pilot Projects;Program Evaluation;programs;Progress Reports;Protocols documentation;Psychology;Recommendation;Records;Reporting;Research;Research Personnel;Series;Services;Social Sciences;Strategic Planning;success;Training;Training Programs;Travel;undergraduate student;United States National Institutes of Health;Universities;University adminstration;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The Joint Graduate Program in Toxicology (JGPT) is a training program designed to instruct doctoral students, postdoctoral fellows, and clinician-scientists in the field of mechanistic toxicology. Trainees study how chemicals in the environment cause disease in people and develop strategies to prevent or treat these illnesses. Comprehensive laboratory and classroom training prepares toxicologists from the JGPT to address emerging environmental health issues confronting our society.

PI_NAMEs: ALEKSUNES, LAUREN M (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: environmental toxicology;Training

PROJECT_TITLE: Training in Environmental Toxicology


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PHR: Project Narrative Neuroimaging Core The Neuroimaging core enables and enhances the scope and quality of the research of past, current and future COBRE projects, and other investigators with the goal of providing access and support to advanced neuroimaging technologies. The core will continue to provide essential research infrastructure to allow understanding of neuronal mechanisms at different scales of processing in both healthy brain function and neural deficits.

PI_NAMEs: STROTHER, LARS  (contact)

PROJECT_TERMS: adaptive optics;Applications Grants;Award;base;Brain;Businesses;Centers of Research Excellence;Charge;cognitive function;cognitive neuroscience;cognitive testing;Communities;Community Hospitals;computational neuroscience;Computer Analysis;Computer Models;Computer software;Consult;Consultations;Contract Services;Core Facility;cost;Data;Data Analyses;data analysis pipeline;Data Collection;data resource;Dedications;density;Education;Electroencephalography;Equipment;Extramural Activities;Faculty;Fee-for-Service Plans;Feedback;Fees;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Funding;Future;Goals;Grant;Health;Hour;Human;Human Resources;Image;Improve Access;improved;Individual;Infrastructure;Institution;Knowledge;Magnetic Resonance Imaging;Maintenance;Measurement;Modality;Modeling;Near-Infrared Spectroscopy;neural;neuroimaging;Neurons;Neurosciences;Neurosciences Research;Nevada;online resource;operation;Phase;Pilot Projects;Policies;Principal Investigator;programs;Psychology;Research;research facility;Research Infrastructure;Research Personnel;Resources;Scanning;Screening procedure;Sensory;Series;Services;Structure;System;Technology;tool;Training;Translating;Universities;University resources;Visual;Wages;Work

PROJECT_TITLE: Neuroimaging Core


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

PHR: Project Narrative Computational Modeling and Analysis (CMA) Core The Computational Modeling and Analysis Core will provide state-of-the-art AI and deep learning frameworks as well as advanced statistical design and analysis support for projects focused on the neurosciences. These services will meet the critical recognized need for computational resources to increase scientific rigor and leverage modern tools and statistical learning for big data.

PI_NAMEs: TAVAKKOLI, ALIREZA  (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;Advanced Development;analytical tool;Artificial Intelligence;Award;Behavioral Sciences;Big Data;Biomedical Research;Centers of Research Excellence;Communities;Complex;computational platform;Computer Analysis;Computer Models;computer science;Computer software;Computer Vision Systems;Computing Methodologies;computing resources;Consult;Contract Services;Core Facility;cost;Data;Data Analyses;Data Analytics;data modeling;Dedications;deep learning;deep learning model;design;Development;Education;Engineering;Ensure;Equipment;Evolution;experience;Experimental Designs;experimental study;Faculty;Fee-for-Service Plans;Fees;Goals;graduate student;Grant;High Performance Computing;Human Resources;Infrastructure;Institution;Journals;Libraries;Machine Learning;machine learning model;Measurement;Measures;Medical;mid-career faculty;Modeling;Modernization;multimodality;neuroimaging;Neurosciences;Neurosciences Research;novel;operation;Phase;Physiological;Pilot Projects;Postdoctoral Fellow;pressure;Principal Investigator;programs;prototype;Reproducibility;Research;Research Activity;Research Infrastructure;Research Personnel;Research Support;Resources;Sample Size;Scientist;self supervised learning;Series;Service delivery model;Services;sound;Specialist;Statistical Computing;Statistical Data Interpretation;statistical learning;Statistical Methods;Statistical Models;statistics;Structure;Supercomputing;System;Time;tool;Training;Translating;trend;United States National Institutes of Health;Universities;Wages;Work


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Digestive diseases that have immunological, metabolic, microbial, and developmental bases represent a significant burden of disease and public health problem in the US and worldwide. The objective of this Program is to prepare the next generation of leaders, scholars and educators performing cutting edge research in Digestive Health and Diseases.

PI_NAMEs: CHANG, EUGENE B (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Disease;Grant;Health;Training

PROJECT_TITLE: Digestive Health and Diseases (DHD) Training Grant


PHR: Program Director/Principal Investigator (Last, First, Middle): Michael A. Webster  PROJECT NARRATIVE Cellular and Molecular Imaging Core Modern neuroscience research requires access to newly emerging technologies and instruments that are often difficult and impractical to support in individual laboratories. Building on its successful operation and support of outstanding investigators at the University of Nevada, Reno (UNR), the COBRE Cellular and Molecular Imaging (CMI) core facility seeks continued funding to transition to a sustainable core to provide support to COBRE faculty investigators and others with an emphasis in gaining fundamental knowledge about the basic function, development and disorders of the nervous system. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: VAN DER LINDEN, ALEXANDER MARTINUS (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Administrative Supplement;Animals;Automation;Award;base;Biology;Cell Separation;Cells;Cellular biology;cellular imaging;Centers of Research Excellence;Consult;Contract Services;Core Facility;cost effective;Data;Data Collection;Detection;Development;Disease;DNA;Education;Emerging Technologies;Ensure;Environment;Equipment;Extramural Activities;Faculty;Fee-for-Service Plans;Fees;Funding;Gel;Goals;Grant;Human Resources;Hybrids;Image;imager;Imaging Device;imaging platform;Imaging technology;Individual;Institution;instrument;Knowledge;Laboratories;Microfluidics;Microscope;microscopic imaging;Microscopy;model organism;Modeling;Modernization;Molecular;Molecular Biology Techniques;molecular imaging;nervous system development;Nervous System Disorder;Nervous System Physiology;Neurosciences;Neurosciences Research;Nevada;operation;Organ;Organism;parent grant;Phase;Pilot Projects;Postdoctoral Fellow;Principal Investigator;Process;Productivity;programs;Proteins;Publications;recruit;Research;Research Infrastructure;Research Personnel;Research Priority;Research Support;Resources;RNA;Robot;Sampling;satisfaction;Services;Specialist;Structure;Students;success;Technology;technology platform;Tilia;Time;tissue culture;Tissues;tool;Training;Training and Education;Translating;two-photon;ultra high resolution;Universities;Visualization;voucher;Wages

PROJECT_TITLE: Cellular and Molecular Imaging Core


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Aging of the vascular endothelial cells is a key event in the decline in organ function and frailty. This proposal will examine how lipid mediators that protect blood vessels become dysfunction in old age, and this knowledge will be used to develop new ways to achieve healthy blood vessels in aging.

PI_NAMEs: HLA, TIMOTHY TUN (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;age related;age related decline;Aging;aging mechanism;aging population;Air;Alveolar;Aorta;Architecture;astrogliosis;Atherosclerosis;Attenuated;beta-arrestin;Binding;Blindness;Blood Vessels;Cell Line;Cell Physiology;Cells;cellular resilience;Central Nervous System;central nervous system vasculature;Chromatin;Chronic;Clinical;combat;Data;Defect;Dementia;design;Disease;Endothelial Cells;Event;Exhibits;frailty;Frequencies;Functional disorder;Gases;Gene Expression;Gene Expression Profile;Genetic;Genetic Models;genetic signature;Genetic Transcription;High Density Lipoproteins;Host Defense;Human;human old age (65+);Inflammation;Inflammatory;influenza infection;Injury;insight;Knock-in;Knowledge;Laboratories;Lead;lipid mediator;Lung;Modeling;Molecular Chaperones;Morbidity - disease rate;mortality;mosaic pattern;mouse genetics;mouse model;Mus;mutant;Nerve Degeneration;novel therapeutic intervention;old mice;Organ;Outcome;Pathologic;Pathologic Processes;Pathology;Pathway interactions;Phenotype;Physiological;Population;programs;Prostaglandins;Pulmonary Fibrosis;pulmonary function;resilience;Resistance;Retina;senescence;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;SLC2A1 gene;Sphingolipids;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Stress;Supporting Cell;Testing;TFRC gene;Therapeutic;Thrombosis;transcriptome;Transgenic Organisms;vascular abnormality;Vascular Diseases;Vascular Endothelial Cell;Vascular System;Vesicle;Viral;Virus Diseases;WNT Signaling Pathway

PROJECT_TITLE: Sphingolipid signaling in age-associated vascular pathology

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD);Neurosciences

PHR: Project Narrative Virtual and Augmented Reality Interaction Core Virtual reality and augmented reality are considered essential to the next generation of visual, cognitive, and behavioral neuroscience research programs. This core will continue to provide the necessary hardware and software development services that will support a wide base of neuroscience and behavioral science faculty at the University of Nevada, Reno.

PI_NAMEs: FOLMER, EELKE  (contact)

PROJECT_TERMS: Area;Augmented Reality;augmented reality headset;base;Behavior;Behavioral;Behavioral Sciences;Centers of Research Excellence;Cognition;Cognitive;cognitive neuroscience;computer science;Computer software;Consult;Core Facility;Data;Dedications;density;design;Education;Educational workshop;Engineering;Environment;Equipment;experience;Extramural Activities;Faculty;faculty support;Feedback;Funding;Future;Goals;Grant;Human Resources;improved;Institution;interest;Neurosciences;Neurosciences Research;Nevada;new technology;next generation;novel;operation;Perception;Phase;Pilot Projects;Policies;Principal Investigator;professor;programs;recruit;Research;Research Personnel;Research Support;Resolution;Resources;Services;software development;Stimulus;Students;Technology;Training;Translating;Universities;Update;virtual;Virtual and Augmented reality;virtual reality;virtual reality headset;Visual;visual neuroscience;visual stimulus


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROLOGY

ORG_STATE: CA

PHR: Project Narrative In order to make major advancements in our treatment and understanding of developmental epileptic encephalopathies we need novel model systems that faithfully recapitulate human disease pathophysiology. By virtue of being human cell derived and having a complex multi-layered 3D architecture, human brain organoids are distinct from models traditionally utilized in biomedical research, and have the potential to make an immediate impact on disease treatment. In the following proposal we will use disease-to-dish induced pluripotent stem cells from 3 patients with epilepsy associated SCN8A gene variants, neural network modeling, and the latest brain organoid generation and fusion techniques to gain novel insights into how this gain of function sodium channel mutation alters neural network formation and function.

PI_NAMEs: SAMARASINGHE, RANMAL A (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: 3-Dimensional;Anticonvulsants;Architecture;Biological Models;Biomedical Research;Brain;Brain region;Calcium;calcium indicator;career;cell type;Cells;Child;Childhood;childhood epilepsy;comparison control;Complex;Data;Defect;Development;developmental epileptic encephalopathy;Disease;drug testing;Drug usage;effective therapy;Electrodes;Elements;Embryo;Epilepsy;epileptic encephalopathies;epileptiform;Etiology;excitatory neuron;extracellular;Frequencies;Functional disorder;gain of function;gain of function mutation;Generations;genetic manipulation;genetic variant;Goals;Hippocampus;Human;human disease;human embryonic stem cell;human induced pluripotent stem cells;Image;Immunohistochemistry;Impaired cognition;Impairment;In Vitro;in vivo;Individual;induced pluripotent stem cell;inhibitory neuron;insight;Interneurons;Medical;memory consolidation;Memory impairment;Methodology;migration;Modeling;Morphology;mutant;Mutation;neonatal seizure;Nervous System Disorder;neural;neural circuit;neural model;neural network;Neural Network Simulation;neurodevelopment;Neurodevelopmental Disorder;Neurons;neurophysiology;new technology;new therapeutic target;novel;novel therapeutics;Organoids;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Pattern;Phenotype;Physiological;Play;Population;programs;Prosencephalon;Public Health;Publishing;Refractory;Research;Rett Syndrome;Role;School-Age Population;Scientist;SCN8A gene;Seizures;Sodium Channel;Sorting;stem cell biology;stem cell organoids;Structure;Subcellular Anatomy;synaptogenesis;Syndrome;System;Techniques;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic target;three dimensional structure;Tissues;Training;two-photon;Validation;voltage;Work

PROJECT_TITLE: Utilizing Human Brain Organoids to Model the Differential Effects of SCN8A Mutation on Cortex and Hippocampus

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


PHR: Project Narrative Pilot Project Program The Pilot Project Program for the Center for Integrative Neuroscience will continue the funding and support for junior faculty and access to required research infrastructure to develop the University of Nevada’s research capacity to contribute to advances in the understanding of normal brain function and neural deficits.

PI_NAMEs: WALSH-SNOW, JACQUELINE C (contact)

PROJECT_TERMS: Area;Award;base;Biomedical Research;Brain;Budgets;career;cellular imaging;Centers of Research Excellence;Cognitive;cohort;Communities;computational neuroscience;Computer Analysis;Computer Models;Core Facility;Data;Development;Discipline;Equipment;Extramural Activities;Faculty;faculty support;Fees;Fostering;Funding;Goals;Grant;Growth;Infrastructure;Institution;Learning;Mentors;Methodology;Mission;Modernization;Molecular;molecular imaging;neural;neuroimaging;Neurosciences;Neurosciences Research;Nevada;Phase;Pilot Projects;professor;programs;Publishing;Reproducibility;Research;research facility;Research Infrastructure;Research Personnel;Research Project Grants;Services;skills;synergism;Techniques;tenure track;tool;Training;translational neuroscience;Universities;Virtual and Augmented reality;voucher;Writing

PROJECT_TITLE: Pilot Project Program