ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Clinical Research;Infectious Diseases;Microbiome;Prevention;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

PHR: Project Narrative Despite the clear association between high-risk human papillomavirus (HR-HPV) and cervical cancer, there is a lack of understanding why some women clear HPV infection while others suffer from chronic infection that leads to cervical dysplasia and cancer. There is emerging evidence that the vaginal microbiome plays an important role in this process however the mechanisms linking vaginal bacteria with host responses, specifically antibody responses, to HPV infection and cervical neoplasia progression are underexplored. This project will study the role of antibody bound and unbound bacteria and associated bacterial functions in women with different HPV infection status and cervical dysplasia pathology.

PI_NAMEs: LANGEL, STEPHANIE N. (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: African American;Antibodies;Antibody Response;Bacteria;Binding;Biological Assay;carcinogenicity;Cells;Cervical;Cervical dysplasia;Cervical Intraepithelial Neoplasia;Cervix Neoplasms;Chronic Disease;chronic infection;cohort;comparison group;Disease;dysbiosis;Enrollment;Environment;Failure;female reproductive tract;Flow Cytometry;Future;Goals;Health;high risk;HPV positive;HPV-High Risk;Human;Human papilloma virus infection;Human Papillomavirus;Immune response;Immune system;Immunoglobulin A;Immunoglobulin G;Immunologic Factors;Immunotherapeutic agent;Individual;Integration Host Factors;Intestines;Lactobacillus;Lesion;Link;Maintenance;Malignant neoplasm of cervix uteri;Medical;Metagenomics;Microbe;microbial;microbiome;microbiota;Monitor;Neoplasms;Normal tissue morphology;novel;Nuclear;Pap smear;pathogenic bacteria;pathogenic microbe;Pathologic;Pathology;Pathway interactions;Persons;Play;Population;Preventive vaccine;Process;recruit;Risk;Role;Sampling;Sorting;Stains;Structure;Swab;Testing;Time;Tissues;vaccine access;Vaccines;Vagina;vaginal microbiome;Woman;Women's cohort;Work

PROJECT_TITLE: Antibody bound bacteria during HPV infection and cervical dysplasia


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative In this study, we will establish a robust data ecosystem for the IMPACT-MH consortium, producing data that is findable, accessible, interoperable, and reusable (FAIR). By adhering to these principles, we aim to greatly accelerate scientific discoveries in mental health research. To achieve these goals, the IMPACT-MH Data Coordination Center will establish three cores: Project Coordination and Data Management Core. Data Standards Core and Data Analytics Core. Through collaborative efforts and the utilization of advanced data management and analytics techniques, we are confident that our team will make significant contributions to the field and advance our understanding of mental health. .

PI_NAMEs: CHEN, YONG ;TAO, CUI ;XU, HUA  (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: Acceleration;Address;Algorithms;Area;Behavior assessment;Big Data;Biological Markers;Characteristics;Clinical;clinical decision-making;clinical phenotype;Common Data Element;Communication;Complex;Comprehension;Computational Technique;Computer Analysis;computer infrastructure;Consensus;Data;Data Aggregation;Data Analyses;Data Analytics;Data Collection;Data Coordinating Center;data ecosystem;data harmonization;data integration;data interoperability;data management;Data Management Resources;data modeling;Data Reporting;data repository;data reuse;Data Set;Data Sources;data standards;data submission;Development;Diagnostic;diagnostic accuracy;digital;Disease;diverse data;Enabling Factors;Ensure;Evaluation;Exhibits;experience;Face;FAIR principles;Fostering;Generations;Goals;health data;Heterogeneity;heterogenous data;improved;Individual;individual patient;Infrastructure;insight;interoperability;Intervention;knowledge graph;Machine Learning;Measures;Mental disorders;Mental Health;mental representation;Methods;Modeling;Monitor;multimodal data;National Institute of Mental Health;Ontology;Patient Care;Patient-Focused Outcomes;personalized medicine;Phenotype;phenotyping algorithm;Process;Prognosis;programs;Records;recruit;Research;Research Domain Criteria;Research Personnel;Resources;Secure;Selection for Treatments;Services;Site;skills;sound;Source;Statistical Data Interpretation;System;Technical Expertise;Techniques;tool;Translations;United States National Institutes of Health;Validation;Validity and Reliability;web portal;Work

PROJECT_TITLE: Coordinating Individually Measured Phenotypes to Advance Mental Health Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (01)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF EDUCATION

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric

ORG_CITY: LOGAN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PHR: PROJECT NARRATIVE Children who have difficulty listening, especially in complex auditory environments, despite clinically normal hearing, are currently underserved because factors underlying their listening problems are not well understood. Our goal is to model the relationship between listening in noise ability and sentence comprehension which is a predictor of academic success in school-age children, with lexical knowledge as a mediator and working memory capacity as a moderator. Results will have direct implications in shifting clinical assessment and intervention paradigms for children with auditory processing problems.

PI_NAMEs: MAGIMAIRAJ, BEULA M;NAGARAJ, NAVEEN K (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 11 year old;Academy;Age;American;Area;Attention;Attentional deficit;Audiology;Auditory;Auditory Perception;Auditory Perceptual Disorders;auditory processing;British;Characteristics;Child;Clinical;Clinical assessments;Cognitive;cognitive control;cognitive load;Communication;comorbidity;Complex;Comprehension;comprehension skill;Cross-Sectional Studies;Data;Development;Diagnosis;Diagnostic;Dyslexia;Education;effective intervention;Environment;Failure;Goals;Growth;Hearing;hearing impairment;Impairment;improved;Individual Differences;individual variation;Intervention;intervention program;Knowledge;Label;Language;language comprehension;Language Development Disorders;language impairment;language outcome;language processing;Learning;lexical;Linguistics;Literature;Mediating;Mediator;middle childhood;Modeling;National Institute on Deafness and Other Communication Disorders;Nature;Noise;normal hearing;Oral;Otitis Media;Parents;Property;prospective;Psychometrics;Publications;Qualifying;reading comprehension;reading difficulties;Recording of previous events;recruit;Recurrence;Reporting;Research;Resources;Retrieval;Sampling;School-Age Population;Short-Term Memory;Societies;Source;speech in noise;Speech Perception;speech processing;Speech-Language Pathology;standardize measure;success;teacher;Testing;Theoretical model;theories;Training;Vocabulary

PROJECT_TITLE: Association between Speech Perception in Noise and Sentence Comprehension in School-age children

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emergency Care;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PUBLIC HEALTH STATEMENT Extreme heat events (EHEs) may intensify COVID-19 (C-19) propagation, representing the interaction of two devastating public health emergencies: the C-19 pandemic and climate change. This proposal will provide the first rigorous evidence of the association between EHEs and C-19 propagation using a quasi-experimental de- sign, as well as identifying individual and other factors increasing risk of C-19-related morbidity during EHEs. Findings will provide an important first step to overcome roadblocks that currently limit tailored public health risk messaging and interventions for individuals vulnerable to C-19-related and extreme heat event-related morbidity and mortality as these two public health emergencies interact. 1

PI_NAMEs: GHOSH, ARNAB KUMAR (contact)

PROGRAM_OFFICER_NAME: BROWN, PATRICK

PROJECT_TERMS: 2019-nCoV;Accounting;Admission activity;Adult;Adverse event;Affect;Age;aging population;Air;American;Area;Award;Behavior;Censuses;Cessation of life;Characteristics;Chronic Disease;Cities;Climate;climate change;climate-related health;Clinical;cohort;Communicable Diseases;comorbidity;Coronavirus;County;COVID-19;COVID-19 morbidity;COVID-19 pandemic;COVID-19 risk;COVID-19 susceptibility;Crowding;Data;Data Sources;design;econometrics;Economically Deprived Population;Environment;ethnic minority;ethnic minority status;Event;evidence base;experience;extreme heat;extreme weather;Federal Government;Foundations;Frequencies;Future;future pandemic;Health;health equity;Hospitalization;Household;human old age (65+);Humidity;improved;indexing;Individual;Infectious Disease Epidemiology;Institution;Intervention;Measures;Medical;Methods;Minority;Minority Groups;Modeling;Morbidity - disease rate;mortality;National Center for Advancing Translational Sciences;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Environmental Health Sciences;Outcome;pandemic preparedness;Pathway interactions;Patients;Physiological;Population;Populations at Risk;Poverty;Prevalence;programs;Public Health;public health emergency;Quasi-experiment;racial minority;Research;Research Personnel;Resources;Risk;SARS-CoV-2 transmission;Scientist;Services;Severities;simulation;socioeconomic disadvantage;socioeconomics;Southwestern United States;spatiotemporal;Specific qualifier value;Sunlight;Temperature;Testing;theories;tool;Translating;translational physician;United States National Institutes of Health;Vaccination;viral pandemic;Vulnerable Populations;Weather;Work

PROJECT_TITLE: The Interaction of Public Health Emergencies: Understanding Nation-wide and City-wide Spatiotemporal Dynamics of COVID-19 Transmission in a Warming World

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-6 (01)]


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Narrative Aging impairs immune cell functions, which causes a reduction in our ability to fight off pathogens. Research has shown that aging causes accumulation of fibrous extracellular matrix material in the lymph nodes, which may change the biophysical properties of the tissue, and immune cell functions have been shown to be impacted by these biophysical properties. Here, we investigate how lymph node biophysical properties change in aging, which has not been investigated.

PI_NAMEs: MAISEL, KATHARINA  (contact);SCARCELLI, GIULIANO

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: Acoustics;adaptive immunity;Adipose tissue;Affect;Age;age related changes;aged;Aging;B-Lymphocytes;biophysical properties;Biophysics;cell behavior;Cell Compartmentation;cell motility;Cell Physiology;Cells;Collagen;Complex;COVID-19;Data;density;Disease;Elastic Tissue;Elasticity;Elastin;Elderly;Environment;Enzymes;experience;Extracellular Matrix;Extracellular Matrix Proteins;Fatty acid glycerol esters;Fibronectins;fighting;Foundations;Frequencies;Future;Hydrogels;imaging modality;Immune;immune function;Immunofluorescence Immunologic;Impairment;Incubated;Individual;Influenza;Investigation;Knowledge;Laminin;Lymph Node Tissue;lymph nodes;Maps;mesenteric lymph node;Methods;Microscopy;migration;milliliter;Mobility decline;Modulus;Motion;Mus;nanoparticle;Nature;old mice;particle;pathogen;pathological aging;Polymers;Property;Regenerative Medicine;Regenerative research;Research;Research Personnel;response;Rheology;Shapes;Skin;Slice;Stress;Structure;Structure-Activity Relationship;System;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Tissues;Vaccination;Vaccines;viscoelasticity;Viscosity;Work

PROJECT_TITLE: Biophysical properties of lymph nodes in aging

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: GM

ED_INST_TYPE: COMPUTER CENTER

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative The Anton 3 supercomputer and data resource to be deployed at the Pittsburgh Supercomputing Center, through this award and in partnership with D. E. Shaw Research, will enable researchers to simulate larger and more complex biomolecular systems hundreds of times faster than any other resource available to the biomedical community and will make the resulting simulation data readily available to all. This powerful and unique resource will bring unprecedented understanding of fundamental processes of biology, leading to better ways to treat disease and improve quality of life.

PI_NAMEs: BLOOD, PHILIP D. (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Academy;Address;anxious;Area;Award;Awareness;base;Binding Proteins;Biological;Biological Process;Biology;Biomedical Research;broadening participation research;Chemicals;Collaborations;Communities;Complex;cost;Creativeness;cyber infrastructure;Data;Data Collection;data management;data mining;data resource;Data Science;Data Set;Development;Disease;Education;Evaluation;FAIR principles;Funding;Gifts;Goals;improved;Infrastructure;innovation;Institution;Instruction;interoperability;Ion Channel;Knowledge;Life;Machine Learning;Membrane;Metadata;Methods;millisecond;Molecular;molecular dynamics;National Institute of General Medical Sciences;National Research Council;Neocortex;next generation;outreach;outreach program;price lists;Process;protein folding;Protocols documentation;Provider;Publications;Quality of life;Reporting;Research;Research Personnel;Research Project Grants;Resources;Science;Secure;service providers;Services;simulation;Speed;Standardization;Students;success;supercomputer;Supercomputing;System;Time;Training Programs;Underrepresented Populations;United States National Academy of Sciences;United States National Institutes of Health;uptake;web portal

PROJECT_TITLE: Breakthrough Molecular Dynamics Research via an Anton 3 Supercomputer

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 BBCB-U (NR)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homicide and Legal Interventions;Mental Health;Mental Illness;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE     During adolescence, exposure to media depicting gun violence, including mass shootings and police-involved shootings of Black people, has been linked to increased anxiety and depression symptoms, as well as racial stress and trauma among Black adolescents. This project seeks to determine if a novel probe of neurocognitive processing (i.e., steady-state visual evoked potentials) and experience sampling of media consumption of gun violence events can be used to predict future adolescent anxiety, depression, and racial inequities. Findings will enhance understanding of the negative effects of specific media content on adolescent mental health, enabling the development of targeted interventions to reduce anxiety and depression, with particular emphasis on addressing racial stress and trauma.

PI_NAMEs: WOODY, MARY LOUISE (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent mental health;Age;Anxiety;anxiety reduction;anxiety symptoms;assigned female at birth;Attention;Behavioral;Biological;Black Populations;Black race;Brain;brain based;Broadcast Media;cognitive task;Communities;community advisory board;Consumption;critical period;depressive symptoms;design;Development;diaries;directed attention;Distress;Electroencephalography;Emotional;Enrollment;Ensure;Event;Exhibits;experience;Exposure to;Face;Feedback;firearm access;Functional disorder;Future;Goals;gun violence;Image;indexing;insight;Intervention;killings;Lead;Link;mass shooting;Measures;media use;Mental Depression;Modeling;Moods;neural;Neurocognitive;neurocognitive test;Neuronal Plasticity;Neurons;novel;Pathway interactions;peer;Perception;Persons;Police;Population;prospective;Race;racial disparity;racial identity;recruit;Reporting;Research;Resolution;response;Risk;Role;Safety;Sampling;school shooting;Signal Transduction;Stimulus;Stress;Surveys;Symptoms;Teenagers;Testing;Time;Trauma;vigilance;Violence;violence exposure;Visit;Visual Cortex;Visual evoked cortical potential;Work

PROJECT_TITLE: Neurocognitive Processing of Gun Violence in the Media: Implications for Adolescent Anxiety, Depression, and Racial Inequities

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-G (01)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Glaucoma, the leading cause of irreversible blindness worldwide, has significant disparities in prevalence, presentation, and treatment in the United States (US). Pragmatic registry-based randomized controlled trials (RRCT) can increase participant diversity, more efficiently enroll patients, improve the generalizability of study findings, and reduce costs. This planning grant helps to prepare for a future RRCT in ophthalmology in the US, and to establish infrastructure vital to support additional pragmatic RRCTs in ophthalmology.

PI_NAMEs: SUN, CATHERINE QING (contact)

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: Adoption;Affect;Attitude;Belief;Blindness;Caring;Cataract Extraction;Clinical;Clinical Research;Clinical Trials;cohort;comorbidity;cost;Data;design;Disparity;Electronic Health Record;Eligibility Determination;Enrollment;Ethics;Ethnic Origin;Ethnic Population;Eye;Feasibility Studies;follow-up;Foundations;Future;Glaucoma;glaucoma surgery;Grant;Guidelines;health care availability;Health Insurance;health related quality of life;improved;Infrastructure;Insurance Coverage;Interview;Lasers;Methodology;Methods;Newly Diagnosed;Ocular Hypertension;Open-Angle Glaucoma;operation;Ophthalmology;Outcome;Paper;Participant;participant enrollment;patient population;Patient Recruitments;Patients;Pattern;Persons;Pharmaceutical Preparations;Population;Population Heterogeneity;Prevalence;Primary Open Angle Glaucoma;primary outcome;Protocols documentation;Publishing;Questionnaires;Race;racial population;Randomized;Randomized, Controlled Trials;recruit;Registries;Research;Sample Size;secondary outcome;socioeconomic disadvantage;Specialist;Specific qualifier value;Structure;Subgroup;Trabeculectomy;treatment as usual;Treatment Efficacy;United Kingdom;United States;United States National Institutes of Health;Vision

PROJECT_TITLE: Designing a Pragmatic Registry-based Randomized Controlled Trial for Open-Angle Glaucoma Treatment in the US

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (01)]


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative This project will identify disparities in access to reproductive healthcare at the U.S. county level from 2009- 2021. This will be the first project to measure reproductive healthcare deserts, or areas where access to reproductive care is limited or nonexistent, and to document the relationship between access to reproductive healthcare and reproductive autonomy and maternal and infant health. This information will allow researchers, policymakers, and practitioners to better understand areas of need and to address inequalities in access to reproductive healthcare by race/ethnicity, socioeconomic status, and rurality.

PI_NAMEs: SENNOTT, CHRISTIE  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;access disparities;Address;Affect;American;Area;Attention;Birth;Birth Intervals;Caring;Characteristics;Clinic;Collaborations;Community Surveys;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;County;dashboard;Data;data integration;data management;Data Scientist;Data Set;Data Sources;Databases;Disadvantaged;Disparity;Ethnic Origin;experience;Family;Federally Qualified Health Center;Funding;Goals;Grain;Growth;Health;health care availability;health disparity;Health Services Accessibility;Healthcare;Human Rights;improved;Individual;Inequality;Infant Health;longitudinal analysis;longitudinal dataset;Maps;Maternal Health;maternal morbidity;Measures;Mediating;Modeling;multilevel analysis;novel;Outcome;Pathway interactions;Pattern;Policies;Policy Maker;Population;postpartum complications;postpartum contraception;Pregnancy;Prenatal care;prepregnancy;Provider;Race;reproductive;Reproductive Health;Research;Research Personnel;response;rural area;rurality;Science;Services;sexual and reproductive health;Shapes;sociodemographics;Socioeconomic Status;structural determinants;Surveys;System;Time;trait;Translating;United States Centers for Medicare and Medicaid Services;United States Health Resources and Services Administration;Variant;Vital Statistics;Woman

PROJECT_TITLE: Reproductive Healthcare Deserts and Inequalities in Maternal and Infant Health

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: EAST LANSING

ORG_DEPT: PATHOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because this work will decipher the antigenic variation mechanism through which Borrelia recurrentis, the agent of louse-borne relapsing fever (LBRF) establishes bacteremic relapses in LBRF human patients. The antigenic variation system is critical for B. recurrentis to evade human antibodies. The anticipated results will advance the knowledge on this neglected disease and its pathogen.

PI_NAMEs: ROGOVSKY, ARTEM S (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TITLE: Characterization of vsp/vlp system of Borrelia recurrentis

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Cachexia;Cancer

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: NARRATIVE The impact of this project lies in advancing the understanding of platelet involvement and significance in cancer cachexia. By targeting platelets in the context of cancer cachexia, this research will provide novel prognostic and therapeutic insights, moving the field forward in a new direction.

PI_NAMEs: VELAZQUEZ, KANDY T (contact)

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: Adoptive Transfer;Antibodies;ApcMin/+ mice;Automobile Driving;Blood;Blood Platelets;Body Weight decreased;Bone Marrow;Cachexia;Cancer Cachexia;Cancer Patient;cancer therapy;Cells;Chemicals;chemokine;chemotherapy;combat;Complex;cytokine;Data;Death Rate;Development;effective therapy;Elements;epidemiologic data;Exhibits;experience;Fibrosis;Functional impairment;Growth;Growth Factor;Hemostatic function;Histopathology;Human;Immune;immune cell infiltrate;Immunologics;Immunophenotyping;Impairment;improved;Inflammation;Inflammatory;Inflammatory Response;insight;Interleukin-6;Link;Macrophage;Malignant Neoplasms;Measures;Mediating;Mediator;Metabolic syndrome;Methods;Modeling;Molecular;mortality;Mus;Muscle;muscle form;Muscle function;Muscle Weakness;Muscular Atrophy;neutrophil;novel;Outcome;Pathway interactions;Patients;Platelet Activation;Platelet Count measurement;Play;prevent;Process;Production;prognostic;Quality of life;recruit;Refractory;Research;Role;Skeletal Muscle;skeletal muscle wasting;Survival Rate;systemic inflammatory response;Testing;Therapeutic;Therapeutic Intervention;Tissues;Transfusion;tumor;Tumor Burden;wasting;Weight

PROJECT_TITLE: The Role of Platelets in Cancer Cachexia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-M (55)]


ADMINISTERING_IC: OH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: WAYNE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: WILLIAM PATERSON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative  This project will accurately determine the longitudinal changes in physical characteristics through the different stages of pregnancy. With this knowledge, we can begin to biomechanically analyze how pregnant individuals perform different occupational tasks as they learn to adapt to their rapidly changing bodies. In turn, we can develop occupational standards and protocols unique to the pregnant population that are based on sound empirical research.

PI_NAMEs: WICKE, JASON  (contact)

PROGRAM_OFFICER_NAME: LIOCE, MARIA

PROJECT_TITLE: Capturing body segment changes during pregnancy to develop an accurate biomechanical model.

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB) are related neurodegenerative diseases in which the protein alpha-synuclein disrupts transport of cargo in vesicles (trafficking) within the cell. We have previously found that increasing palmitoylation (modification of proteins by the fatty acid palmitate) by inhibiting a depalmitoylating enzyme, acyl protein thioesterase-1 (APT1), helps restore trafficking. In this proposal, we evaluate the potential of palmitoylation as a therapeutic strategy for PD and DLB by identifying and validating the specific proteins affected by APT1 inhibition and also determining if alpha-synuclein alters the global palmitoylation profile in a mouse model of PD/DLB.

PI_NAMEs: HO, GARY P. H. (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Abnormal coordination;Address;Affect;alpha synuclein;Alpha-Synuclein transgenic mouse;Alzheimer's disease related dementia;Binding;Biological;Biological Assay;Biotin;Brain;Cell Physiology;Cells;Cellular biology;clinical translation;Cognitive;Compensation;Cysteine;Cytopathology;Defect;Dementia;Dementia with Lewy Bodies;Development;Disease;Drug Targeting;endoplasmic reticulum stress;Ensure;Enzymes;Fatty Acids;Functional disorder;Gait;Gene Modified;Genes;Goals;Golgi Apparatus;Human;human induced pluripotent stem cells;Impairment;improved;Individual;Induced Neurons;Induced pluripotent stem cell derived human neuron;inhibitor;insight;interest;Knowledge;lentivirally transduced;Lewy Bodies;Mass Spectrum Analysis;Measures;Membrane;Methods;morris water maze;Motor;mouse model;Mus;mutant;Mutation;nanomolar;neural;Neurodegenerative Disorders;neuronal cell body;Neurons;novel therapeutic intervention;overexpression;Palmitates;palmitoylation;Parkinson Disease;Parkinson's Dementia;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;Physiological;Play;Post-Translational Protein Processing;pre-clinical assessment;Prevalence;prevent;Process;Protein Analysis;protein transport;Proteins;Proteomics;Rattus;receptor;Research Priority;Rest Tremor;Rodent;Rodent Model;Role;Saturated Fatty Acids;Set protein;spatial memory;Specificity;Symptoms;Synapses;Synaptic plasticity;synucleinopathy;Testing;Therapeutic;therapeutic target;Toxic effect;trafficking;Transgenic Mice;Transgenic Organisms;Translating;translational therapeutics;Vesicle;Work

PROJECT_TITLE: Defining The Substrates of Acyl Protein Thioesterase-1: Their Role in Modulating Alpha-Synuclein Toxicity

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Infectious Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative We seek to understand how infection with the enteric pathogen, Yersinia pseudotuberculosis, impacts M cells in the intestinal epithelium that overlying the Peyer’s patches in the small intestine. We will build a genetic system based on mouse intestinal organoids that express Cas9 only in M cells and use this system to interrogate how M cell proteins that are targeted by the Y. pseudotuberculosis Yops interfere with M cell functions. In addition, we will measure the numbers of M cells during an acute Y. pseudotuberculosis infection.

PI_NAMEs: MECSAS, JOAN C (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Acute;acute infection;Anoikis;antigen binding;Antigen Receptors;Antigens;Apical;Binding;Biological Models;Cell Communication;Cell Line;Cell Physiology;cell type;Cells;CRISPR/Cas technology;Data;design;Development;Enteral;enteric pathogen;Epithelium;Event;extracellular;gastrointestinal epithelium;Genetic;Goals;Guide RNA;Gut associated lymphoid tissue;Homeostasis;Host Defense;Human;ileum;Immune;Immune response;Immunofluorescence Immunologic;Immunoglobulin A;Immunologics;Impairment;in vivo;Infection;intestinal epithelium;Intestines;Invaded;Ligation;Lymph;Lymphatic System;M cell;Measures;Minority;Modeling;Molecular;monolayer;mouse model;Mus;mutant;Oral;oral infection;Organoids;particle;Pasteurella pseudotuberculosis;pathogen;pathogenic bacteria;pathogenic virus;Pathway interactions;Peyer's Patches;Population;prevent;Proteins;receptor;response;Role;Salmonella typhimurium;Sampling;Small Intestines;superinfection;Surface;System;Techniques;Testing;Tissues;tool;transcription factor;transcytosis;Type III Secretion System Pathway;Virulence;Work;Writing;Yersinia pseudotuberculosis Infections

PROJECT_TITLE: Impact of Yersinia pseudotuberculosis infection on M cells in murine infections

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative This project will develop a universal sensitivity analysis framework for unmeasured confounding in drug-related public policy evaluation, which can simultaneously handle three data challenges commonly encountered in sensitivity analyses in drug-related policy research: non-binary treatments, multiple outcomes, and subgroup- specific effects. Such a universal sensitivity analysis framework will produce more reliable and robust causal inference results for drug-related public policy research in much broader settings. The new framework will be applied to study the causal influences of mobility policies (e.g., social distancing policies) on drug overdose deaths among the overall population and those among different racial groups, as well as other outcomes such as tobacco use and excessive drinking.

PI_NAMEs: HENG, SIYU  (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: Address;Adopted;Age;Alcohols;Behavior;Cannabis;Censuses;Communication;Confidence Intervals;County;Data;data resource;Disparity;dose information;Drug usage;Economics;experimental study;Health;Heavy Drinking;indexing;interest;Justice;Language;Legal;Measures;Methods;National Institute of Drug Abuse;Nature;nonbinary;Observational Study;open source;Outcome;Output;overdose death;Pharmaceutical Preparations;Policies;Policy Analysis;Policy Research;Population;Public Policy;public policy on alcohol;Race;racial population;Randomized;Research Personnel;Social Distance;Societies;Socioeconomic Status;Source;Statistical Methods;Subgroup;System;Taxes;Tobacco;tobacco control;Tobacco use;Transportation;United States;user-friendly;Vital Statistics;Work

PROJECT_TITLE: Universal Sensitivity Analysis for Unmeasured Confounding in Drug-Related Public Policy Evaluation

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed studies are relevant to public health, as they aim to greatly improve the reference sequence database for eukaryotic pathogens, VEupathDB, a Bioinformatics Resource Centers (BRCs) project funded by the National Institute of Allergy and Infectious Diseases (NIAID). By significantly increasing the number of functionally annotated genes in this database, the research outcomes will offer crucial insights into the underlying biology of parasitic eukaryotes that have a significant impact on global health. This expanded knowledge will aid in identifying promising targets for further functional studies and ultimately contribute to the development of innovative therapeutic interventions for infectious diseases.

PI_NAMEs: PHAN, ISABELLE  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Affect;Algorithms;Base Sequence;bioinformatics resource;Biology;Collaborations;Communicable Diseases;Databases;Dedications;Development;Disease;Ensure;Eukaryota;Funding;Genes;Genome;genome sequencing;global health;Human;improved;Infectious Diseases Research;innovation;insight;Knowledge;Leishmania;Manuals;Methods;Modeling;molecular sequence database;Names;National Institute of Allergy and Infectious Disease;Natural Language Processing;novel;novel therapeutic intervention;Organism;Orthologous Gene;Outcomes Research;Parasites;pathogen;pathogen genome;Persons;Positioning Attribute;Process;protein data bank;protein function;Proteins;Protocols documentation;Public Health;Published Comment;reference genome;repository;Sequence Alignment;Speed;structural biology;Structure;Techniques;Technology;therapeutic development;Therapeutic Intervention;tool;Update;whole genome;Zea mays

PROJECT_TITLE: A Structure-based orthology approach to predict protein function in eukaryotic parasites

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ORG_CITY: Boston

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: PROJECT NARRATIVE  A major bottleneck in untargeted metabolomics workflows is assigning chemical identities to measured spectra. This work proposes several novel computational techniques to annotate spectral measurements. We anticipate that this work will advance discoveries in biomedical research and have direct benefits to human health.

PI_NAMEs: HASSOUN, SOHA  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Algorithms;annotation  system;Biological;biomarker discovery;Biomedical Research;Chemicals;Computational Technique;Data;data modalities;Data Set;data sharing;deep learning;deep learning model;experience;experimental study;Gases;Goals;graph neural network;Health;Human;improved;innovation;instrument;Learning;Liquid substance;Maps;Mass Spectrum Analysis;Measurement;Measures;Metabolism;metabolomics;Modeling;Molecular;neural network;novel;Ontology;Performance;Research;success;tandem mass spectrometry;Technology;Training;Translations;Work

PROJECT_TITLE: Deep Learning Models for Metabolomics Analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: Project Narrative Human health and disease is governed by the cellular and molecular processes of life and detail down to the atomic structure of individual proteins is often required to understand the mechanisms that control disease progression and to design drugs and other therapies such as vaccines to combat them. X-ray crystallography is one of the prime technologies used to generate high quality structures, generated from crystallographic data collected at large US facilities like synchrotrons and X-ray free electron lasers. The DIALS National Resource will support software for the processing of crystallographic data in automated pipelines that will accelerate the discovery of new treatments and improve health outcomes.

PI_NAMEs: BREWSTER, AARON SAMUEL (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Achievement;Address;Adoption;Advisory Committees;base;beamline;Biological;cluster computing;Code;Collaborations;combat;Communities;Computer software;computerized data processing;COVID-19;Crystallography;Data;Data Analyses;data archive;Data Collection;Data Files;data quality;Data Set;Decision Making;Dependence;design;detector;Development;Diamond;Disease;Disease Progression;disorder control;Documentation;Drug Design;Education and Outreach;Ensure;Environment;experimental study;Exposure to;Feedback;file format;flexibility;Funding;Future;Goals;graphical user interface;Health;Human;human disease;Image;improved;Individual;International;Intervention;large datasets;Libraries;Life;Light;Maintenance;Malaria;Memory;Molecular;open source;operation;Outcome;Pattern;Performance;Phase;Photosynthesis;portability;Positioning Attribute;Process;programs;Progress Reports;protein structure;Proteins;Pythons;R24;Reading;Research;research and development;Research Personnel;Resources;Roentgen Rays;Schedule;Scientist;Signal Transduction;Site;Software Design;Software Tools;Source;Speed;structural biology;Structure;Synchrotrons;System;Technology;technology development;Testing;tool;Training;Update;Vaccines;Writing;X-Ray Crystallography;x-ray free-electron laser

PROJECT_TITLE: DIALS: supporting structural biology through open source diffraction processing software


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Women's Health Research

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

PHR: Project narrative Fuchs corneal endothelial dystrophy (FECD) is a common disease leading to vision impairment worldwide. Corneal transplantation is the only therapy to date, however post-surgical complications and availability of donor corneas are serious challenges. This project will establish a complete FECD mouse model (currently unavailable) that will facilitate the study of the pathological process and testing of potential therapies.

PI_NAMEs: OGANDO, DIEGO  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 1 year old;Acceleration;Acute;Affect;Age;Age Years;analog;Apoptosis;Appearance;Basement membrane;Biological Markers;Cell Death;Cell Density;cell type;Cells;Cessation of life;Characteristics;Chimeric Proteins;Clinical;Code;Cornea;Corneal edema;Corneal Endothelium;corneal epithelium;density;Deposition;Descemet's membrane;Disease;Disease Pathway;Doxycycline;Edema;Endothelial Cells;Endothelium;Enterobacteria phage P1 Cre recombinase;Environment;Estrogen Receptors;Event;Eye;Fluorescence;Fuchs' Endothelial Dystrophy;Functional disorder;Gene Expression;Gene Mutation;Generations;Genes;genetic manipulation;Genotype;Goals;graft failure;Hearing;Human;Hydration status;In Vitro;Induction of Apoptosis;Inherited;Internal Ribosome Entry Site;Keratoplasty;knock-down;Knock-in;Knock-in Mouse;Knock-out;Link;LoxP-flanked allele;Measures;Medical;men;Messenger RNA;Missense Mutation;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Mus;mutant;Mutation;Osmolar Concentration;overexpression;Oxidative Stress;Pathologic;Pathologic Processes;Persons;Phenotype;Population;Production;promoter;Pump;Reactive Oxygen Species;receptor;Reporter;Research Personnel;Response Elements;Retina;SOD2 gene;System;Tamoxifen;Terminator Codon;Testing;Tetracyclines;Thick;Tomatoes;tool;Transcription Coactivator;Translating;ultraviolet irradiation;Urine;Visual impairment;Women's prevalence

PROJECT_TITLE: Models of Fuchs Corneal Endothelial Dystrophy

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Huntington's Disease;Mental Health;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Apathy is the most prevalent neuropsychiatric symptom in Huntington’s disease (HD) and is strongly associated with cognitive dysfunction and suicide, which is the third most common cause of death in HD. The treatment of apathy should be a priority in the clinical care of HD patients, but the etiology or pathophysiology of apathy in HD is unknown. Understanding the mechanisms that regulate apathy in HD is crucial to develop effective treatments to prevent unnecessary deaths and improve the quality of life of patients with HD.

PI_NAMEs: GOMEZ-PASTOR, ROCIO  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Ablation;Activities of Daily Living;Affect;Area;Astrocytes;Atrophic;Axon;Behavior;Brain;brain morphology;Brain region;CAG repeat;Caregivers;Cause of Death;Cells;Cessation of life;clinical care;Cognition;Corpus striatum structure;Coupled;diphtheria toxin fragment A;effective therapy;Etiology;experimental study;Fascicle;Feeling suicidal;Functional disorder;Future;General Population;Genes;Genetic Markers;Genetic Transcription;Glial Fibrillary Acidic Protein;Gliosis;Goals;gray matter;Huntington Disease;Huntington gene;Immunofluorescence Immunologic;Impaired cognition;improved;Inflammation;Injections;insight;Knowledge;Lesion;Medial;Mediating;Mood Disorders;motivated behavior;Motivation;Motor;motor disorder;motor symptom;mouse model;Movement;Mus;Myelin Basic Proteins;nano-string;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuropsychiatric symptom;neuropsychiatry;Patients;Play;Population;Population Heterogeneity;Prefrontal Cortex;prevent;Process;progressive neurodegeneration;Proteomics;psychiatric comorbidity;Quality of life;Regulation;Research;Risk Factors;Role;Severity of illness;Slice;suicidal behavior;Suicide;System;systemic inflammatory response;Testing;touchscreen;transcriptomics;Travel;Viral;white matter

PROJECT_TITLE: White matter-associated striatal astrocytes and their role in apathy in Huntington's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Stroke

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative There is currently no disease specific treatment for patients with brain hemorrhage. Multiple surgical clinical trials have failed to show benefit in outcomes. The prospective study proposed here will examine the use of magnetic resonance imaging to assess the damaged tissues around the bleed and to examine if these tissues are salvageable. The results of this study will help select patients for an intervention in future clinical trials.

PI_NAMEs: ALKHACHROUM, AYHAM ;KOCH, SEBASTIAN  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Acute;acute stroke;American Heart Association;Anisotropy;Area;Axon;axon injury;biomarker selection;Brain hemorrhage;Caring;Cerebral hemisphere hemorrhage;Cerebrum;Clinical;Clinical Trials;Corticospinal Tracts;Data;Data Analyses;Deterioration;Diffusion Magnetic Resonance Imaging;Disease;Evolution;Excision;follow-up;functional outcomes;Future;Goals;Guidelines;Hematoma;Hemorrhage;Hour;Image;imaging biomarker;imaging detection;Imaging Techniques;improved;individualized medicine;Injury;innovation;Institution;Internal Capsule;Intervention;Ischemic Stroke;Knowledge;Magnetic Resonance;Magnetic Resonance Imaging;Measures;Mechanical Stress;Mechanics;Mission;Motor;motor recovery;National Institute of Neurological Disorders and Stroke;Neurology;neurosurgery;novel;Operative Surgical Procedures;Outcome;Participant;Patient Selection;Patients;Pattern;Phase III Clinical Trials;preservation;Prospective Studies;putamen;Radiology Specialty;randomized, clinical trials;Recommendation;Recovery;Recovery of Function;Reporting;Risk;Spinal Cord;Stroke;Symptoms;Testing;Thalamic structure;Therapeutic;Therapeutic Intervention;Time;Tissues;United States;white matter

PROJECT_TITLE: MRS DITCH - Magnetic Resonance Selection with DIffusion Tensor Imaging in Cerebral Hemorrhage

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE The UCSF Alzheimer’s Disease Research Center (ADRC) will benefit public health by advancing knowledge about brain conditions that cause cognitive decline and dementia. The ADRC collects data about medical and neurological conditions, cognitive test performance, DNA and blood samples, brain images and autopsy. These data are shared with other researchers to advance science on aging and dementia.

PI_NAMEs: RABINOVICI, GIL DAN (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Academia;Acceleration;accurate diagnosis;African American population;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;American;Asian;Asian Americans;Autopsy;Basic Science;behavioral impairment;Biological Markers;Biology;Biometry;Black race;Blood specimen;Brain;brain health;Brain imaging;California;career;catalyst;Chinese;Chinese American;chronic traumatic encephalopathy;Clinical;clinical phenotype;Clinical Research;Clinical Trials;cognitive testing;cohort;Collaborations;Communities;community advisory board;community engagement;Creutzfeldt-Jakob Syndrome;Data;data management;data sharing;Dedications;Dementia;Development;Diagnosis;Diagnostic;diagnostic criteria;Discipline of Nursing;Disease;DNA;drug development;Early Diagnosis;early onset;Early Onset Alzheimer Disease;Education;Education and Outreach;education research;Endowment;Epidemiology;Faculty;Foundations;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Funding;Future;Genetic;Geriatrics;Grant;healthy aging;Heterogeneity;Home;Image;Impaired cognition;improved;Industry;Industry Collaboration;innovation;Institution;International;K-Series Research Career Programs;Knowledge;Latin America;Latino;Leadership;Link;Medical;mild cognitive impairment;Molecular;molecular imaging;multidisciplinary;Nerve Degeneration;Network-based;Neurologic;Neurologist;Neurology;Neuropsychology;Neurosciences;next generation;normal aging;novel;novel strategies;outreach;Participant;Pathologic;Pathology;performance tests;Persons;Population Heterogeneity;Positioning Attribute;Prevention;Prion Diseases;programs;protein TDP-43;Psychiatry;Public Health;Publications;recruit;Research;Research Personnel;resilience;Resources;Risk;Role;Sampling;San Francisco;Science;Secure;Site;social health determinants;statistics;Syndrome;tau Proteins;Training;training opportunity;Training Programs;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: New Approaches to Dementia Heterogeneity

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

PROJECT_TERMS: Administrative Supplement;Administrator;Advisory Committees;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Back;base;Basic Science;Biological;Biological Markers;brain health;career;career development;Caring;chronic traumatic encephalopathy;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communication Tools;Communities;community advisory board;community engagement;community partners;COVID-19 pandemic;Creativeness;Data;data management;data sharing;data submission;Dementia;Development;Discipline;Disease;Education;Education and Outreach;education research;Endowment;Ensure;Equilibrium;Ethics;Evaluation;Faculty;Fostering;Foundations;Frontotemporal Dementia;Funding;Generations;Grant;Heterogeneity;Human;Image;improved;Industry;Infrastructure;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;International;Knowledge;Lead;Leadership;Mentors;mild cognitive impairment;Monitor;multidisciplinary;Nerve Degeneration;neuroimaging;neuropathology;Neurosciences;novel;novel strategies;Outcome;patient engagement;Peer Review;Persons;Phenotype;Policies;Population Heterogeneity;Procedures;Process;Productivity;programs;Publications;Regulation;Reporting;Research;Research Personnel;Resources;Sampling;Scanning;Science;Scientist;Secure;Services;social health determinants;Strategic Planning;Structure;Syndrome;synergism;therapy development;Training;Training Programs;TREM2 gene;United States National Institutes of Health;Universities;Vision;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Core A - Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Emerging Infectious Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PI_NAMEs: POSSIN, KATHERINE LAUREL (contact)

PROJECT_TERMS: Acceleration;Address;Age of Onset;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;Autopsy;base;Behavior;Behavioral;behavioral impairment;Biological Markers;brain health;Caring;Chinese;Chinese American;chronic traumatic encephalopathy;Clinical;Clinical assessments;clinical care;Clinical Data;clinical diagnosis;clinical phenotype;clinical practice;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive testing;cohort;Collaborations;Collection;Communities;Community Healthcare;Data;data acquisition;data sharing;Dementia;demographics;design;Development;Diagnosis;diagnostic strategy;Differential Diagnosis;digital;Dimensions;Disease;Doctor of Philosophy;Early Diagnosis;early onset;Emotions;Enrollment;Ensure;Equity;Evaluation;Executive Dysfunction;Faculty;follow-up;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Funding;Genetic;Goals;Grant;Health;Heterogeneity;Human Resources;Image;improved;Infrastructure;innovation;International;K-Series Research Career Programs;Latino;Lead;Life Style;Magnetic Resonance Imaging;Measures;Medical Students;member;Memory;Mentorship;Methods;mild cognitive impairment;Mission;Modeling;Molecular;molecular subtypes;multidisciplinary;Nerve Degeneration;neural;neurobehavioral;neuroimaging;Neurologist;Neurology;Neuropsychology;novel;novel strategies;Onset of illness;outreach program;Participant;Pathologic;Patients;Phenotype;Plasma;Play;Population Heterogeneity;Postdoctoral Fellow;precision medicine;Prion Diseases;Prions;Recording of previous events;Registries;Research;Research Infrastructure;Research Personnel;Research Support;Research Training;Resources;Role;Rotation;San Francisco;social cognition;social health determinants;Syndrome;Telephone;tool;trial readiness;Underrepresented Populations;Visit;volunteer;Work

PROJECT_TITLE: Core B - Clinical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: RANKIN, KATHERINE P (contact)

PROJECT_TERMS: Acceleration;accurate diagnosis;Address;Aging;Alzheimer's disease related dementia;analytical method;Architecture;Basic Science;Biological Markers;Biometry;Brain;career;Clinical;Clinical Research;Collection;Complex;complex data;Consultations;Creativeness;Custom;Data;Data Analyses;Data Analytics;Data Collection;data infrastructure;data integration;data management;Data Management Resources;data resource;Data Set;data submission;data tools;Dementia;design;Disease;Early Diagnosis;education research;Educational process of instructing;Ensure;Epidemiologist;Epidemiology;Etiology;experience;Faculty;Foundations;Generations;Genetic;genetic signature;Genotype;Goals;Heterogeneity;Human Resources;Image;improved;Infrastructure;innovation;insight;Institution;investigator training;Leadership;Link;Memory;Modeling;multidisciplinary;Natural History;Nature;Neuroanatomy;neurobehavioral;Neurologic;Neurology;neuropathology;novel strategies;novel therapeutics;open source;Patients;Pattern;Phenotype;Population Heterogeneity;Positioning Attribute;predictive modeling;Process;programs;proteomic signature;quality assurance;Quality Control;Recommendation;Research;Research Design;Research Methodology;Research Personnel;Resources;Signs and Symptoms;Solid;Source;Statistical Data Interpretation;Statistical Methods;Structure;structured data;Support System;support tools;Syndrome;System;tool;Training;Training and Education;Training Support;Translational Research;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: Core C - Data Management and Statistical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: SEELEY, WILLIAM W (contact)

PROJECT_TERMS: Age;Age of Onset;Alzheimer's Disease;Anatomy;Autopsy;Basic Science;Biological;Biological Markers;biomarker discovery;Brain;Brain Stem;Cell Nucleus;Clinical;clinical conference;cohort;Collaborations;Communities;Complex;Consensus;Data;Databases;Dementia;design;Diagnosis;Diagnostic;digital pathology;Disease;DNA;Dura Mater;Equipment and supply inventories;Event;Fostering;Freezing;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Genetic;Genotype;Goals;Heterogeneity;Human;Image;improved;innovation;International;Leadership;Link;Liquid substance;loss of function;meetings;Methods;molecular imaging;Nerve Degeneration;Neurodegenerative Disorders;neurodevelopment;neuroimaging;Neurologist;neuropathology;Neurosciences;next generation;novel strategies;Paper;Participant;Pathogenicity;Pathologic;Pathology;Patient Recruitments;Patients;Phenotype;programs;protein TDP-43;Publishing;Qualifying;recruit;Research;Research Personnel;Research Support;Research Training;Resources;RNA Splicing;Role;Rotation;Sampling;Scientist;Secure;Services;Specimen;Spinal Cord;Stains;success;symposium;Symptoms;tau Proteins;tau-1;tissue processing;Tissues;Training;transcriptomics;Translational Research;Underrepresented Populations;Validation;Work

PROJECT_TITLE: Core D - Neuropathology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: LANATA, SERGGIO CARLO (contact)

PROJECT_TERMS: Accounting;Address;Adult;African American;African American population;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;Asian;Awareness;behavioral impairment;Biological Markers;Black race;Brain;brain health;Caring;Chinese;Chinese American;chronic traumatic encephalopathy;Clinic;Clinical;clinical care;clinical center;Clinical Research;Cognitive;cohort;Collaborations;Communities;community advisory board;community based participatory approach;community based participatory research;community center;community clinic;community living;Community Outreach;community partners;Data;Dementia;Development;Diagnosis;Disease;Education;education research;Elderly;Eligibility Determination;Enrollment;Ensure;Equity;Evaluation;Evaluation Research;Event;Frontotemporal Lobar Degenerations;Genetic;Goals;health disparity;Health education;Health Personnel;Heterogeneity;Image;Impairment;improved;innovation;interest;International;Language;Latin America;Latino;Lead;learning strategy;Linguistics;Link;Liquid substance;Lived experience;Measures;Mentors;metropolitan;mild cognitive impairment;Movement;Multilingualism;multimodality;Neighborhoods;Nerve Degeneration;neuropathology;novel strategies;operation;Outcome;outreach;outreach program;Participant;participant retention;Patients;Population Heterogeneity;primary care provider;Prion Diseases;programs;Questionnaires;Recommendation;recruit;Recruitment Activity;Research;Research Methodology;Research Personnel;Risk;San Francisco;social determinants;sociodemographics;Spanish;stem;success;Syndrome;Training;Training Programs;Training Support;Underrepresented Populations;underserved community;Visit;vulnerable community;Work

PROJECT_TITLE: Core E - Outreach, Recruitment, and Engagement Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

PI_NAMEs: YOKOYAMA, JENNIFER S (contact)

PROJECT_TERMS: accurate diagnosis;Age of Onset;Aging;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Amyloid;Argentina;Belief;biobank;Biological;Biological Markers;Biological Specimen Banks;biomarker discovery;Blood;Blood specimen;C9ORF72;career;cell repository;Cells;Classification;Clinical;Clinical Research;Clinical Trials;cohort;Collaborations;Collection;Communities;Data;Data Analyses;Data Management Resources;Dementia;design;Development;Diagnosis;Diagnostic;diverse data;DNA;Doctor of Philosophy;Early Diagnosis;early onset;Education;education research;Ensure;exome;exome sequencing;experience;Faculty;Fibroblasts;Frontotemporal Dementia;gene discovery;Generations;Genetic;Genetic Risk;genome sequencing;genome-wide;Genomics;Genotype;Goals;Grant;Health;Heterogeneity;Human;Image;improved;induced pluripotent stem cell;Infrastructure;innovation;interest;International;Investigation;Lead;Leadership;Light;Liquid substance;Measurement;Measures;Mentors;Mission;molecular phenotype;multidisciplinary;Nerve Degeneration;Neurodegenerative Disorders;neurofilament;Neurons;novel;novel marker;novel strategies;Participant;participant enrollment;Pathology;Pathway interactions;Patient Selection;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Philosophy;Pilot Projects;Plasma;Population;Population Heterogeneity;Positioning Attribute;precision medicine;presenilin-1;presenilin-2;Procedures;prognostic;Protein Isoforms;Proteins;Proteomics;Proxy;rare variant;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Resources;Risk;risk variant;Sampling;Scientist;screening;SNP array;Specimen;Standardization;Synapses;Syndrome;synergism;System;tau Proteins;tau-1;TBK1 gene;Techniques;Technology;Training;transcriptomics;Translational Research;TREM2 gene;Underrepresented Populations;United States National Institutes of Health;Universities;Validation;whole genome;Work

PROJECT_TITLE: Core G - Biomarker Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Palliative Care

PI_NAMEs: ROSEN, HOWARD J (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Basic Science;behavioral neurology;brain health;California;Capsicum;career;Career Mobility;Clinical;clinical center;Clinical Research;Clinical Sciences;Clinical Trials;Communication;Communities;Dementia;Development;Diagnostic;Discipline;Discipline of Nursing;diversity and equity;Education;education research;Educational Curriculum;Educational workshop;Ensure;Environment;Epidemiology;Equity;experience;Exposure to;Faculty;Fellowship;Foundations;Funding;Geriatric Psychiatry;Geriatrics;Grant;Heterogeneity;Home;Image;interest;Leadership;Medical;Medical Research;medical specialties;Medical Students;Medicine;meetings;Memory;Mental disorders;Mentorship;Methods;Minority;Modeling;multidisciplinary;Nerve Degeneration;Neurology;Neuropsychology;Neurosciences;novel strategies;Online Systems;outreach;Palliative Care;Phenotype;Positioning Attribute;Postdoctoral Fellow;Program Description;programs;Psychiatry;Publications;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Research Project Summaries;Research Training;Resources;Role;Rotation;Science;Scientist;Secure;Structure;Students;symposium;Training;training opportunity;Training Programs;trend;Underrepresented Populations;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: accurate diagnosis;Age of Onset;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid;analytical tool;Anatomy;Archives;arterial spin labeling;Autopsy;Biological Markers;brain volume;Cerebrum;Chinese;chronic traumatic encephalopathy;Clinical;Collaborations;Collection;Cross-Sectional Studies;Data;data management;Data Set;Dementia;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Early Diagnosis;Early Onset Alzheimer Disease;education research;Educational process of instructing;emotional functioning;Exclusion;executive function;Feedback;fluorodeoxyglucose positron emission tomography;Functional Magnetic Resonance Imaging;Funding;Genetic;Heterogeneity;Image;Image Analysis;image archival system;imaging approach;Impairment;Individual;innovation;International;Language;Latino;Leadership;Ligand Binding;Ligands;Link;longitudinal analysis;Magnetic Resonance Imaging;Measures;Molecular;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;neuropathology;Neurosciences;novel strategies;outreach;Participant;Pathologic;Patient Recruitments;Patients;Perfusion;Plasma;Population;Positron-Emission Tomography;programs;Quality Control;rapid diagnosis;recruit;Research;Research Personnel;Research Support;Research Training;Rest;Role;Signal Transduction;Site;skills;social;Staging;Standardization;statistics;Structure;Syndrome;tau Proteins;Techniques;tool;Training;Training Programs;Training Support;Validation;Visuospatial;white matter;Work

PROJECT_TITLE: Core F - Neuroimaging Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Hematology

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: TITLE: Pathogenesis of Vascular Anomalies with GNAQ mutations. PROJECT NARRATIVE: A class of disfiguring and life-threatening vascular anomalies is associated with mutations in the GNAQ gene that cause excessive, uncontrolled activity of the protein encoded by this gene. A key roadblock to finding effective, non-invasive treatments has been the lack of animal models for the study of disease development and treatment. Our project goals are to devise a murine model to study vascular disease progression and complications in response to GNAQ activating mutation, and to identify targeted treatments for patients.

PI_NAMEs: BOSCOLO, ELISA  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Address;Affect;Animal Model;Automobile Driving;Blood capillaries;Blood Coagulation Disorders;blood perfusion;Blood Platelets;Blood Vessels;Cell Proliferation;Cells;chronic pain;Complication;Data;Defect;Development;Disease;disease phenotype;Disease Progression;Drug Targeting;Endothelial Cells;Endothelium;experience;experimental study;extend lifespan;Fibrin;G-substrate;gain of function;Gene Family;Generations;Genes;Genetic;GNAQ gene;Goals;Growth;guanine nucleotide binding protein;Hemostatic Agents;Hyperactivity;improved;In Vitro;in vivo;inhibitor;innovation;insight;Knowledge;Lesion;Life;Lobule;Maintenance;MAP Kinase Gene;MEKs;Modeling;Molecular;Molecular Target;Morphogenesis;mouse model;mutant;Mutant Strains Mice;Mutate;Mutation;novel;novel therapeutics;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Peptide Hydrolases;pharmacologic;Physiological;Polymers;Positioning Attribute;preclinical development;preclinical study;prevent;programs;Proliferating;protein activation;Proteins;Research;response;Role;Signal Pathway;Signal Transduction;Study models;System;targeted treatment;Testing;therapeutic target;Thrombin;Thrombocytopenia;Thromboplastin;Tissues;transcriptomics;Transgenic Organisms;Treatment Efficacy;Up-Regulation;Uveal Melanoma;vascular abnormality;Vascular Diseases;Vascular Permeabilities;venule

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDD-Q (81)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Neurodegenerative

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE The proteome encompasses all the proteins present in a cell, tissue, or body fluid, serving as the fundamental framework for biological processes. It plays a crucial role in defining the characteristics of an organism. Despite its immense potential, the utilization of proteomics, a method for comprehensive proteome mapping based on the use of mass spectrometry, remains limited in our endeavors to comprehend diseases and largely unexplored in clinical investigations. This can be primarily attributed to the technology’s lower sample throughput and sensitivity compared to genomic technologies. We request funding for a novel mass spectrometer addressing both of these problems with an unprecedented performance several folds superior to existing instruments. The mass spectrometer will be used in several projects aimed at a better understanding of complex diseases such as cancer and neurodegenerative disorders.

PI_NAMEs: HAAS, WILHELM  (contact)

PROGRAM_OFFICER_NAME: CHEN, YONG

PROJECT_TERMS: Acetylation;Address;Alzheimer's Disease;Biological Markers;biological systems;Boston;Cancer Center;Cell Line;Cells;Clinical Treatment;Combined Modality Therapy;Complex;cost;Data;Detection;detection limit;Development;Diagnostic;Disease;enzyme activity;Funding;General Hospitals;Genomics;human disease;Institution;instrument;Ions;Label;Malignant Neoplasms;Maps;mass analyzer;mass spectrometer;Mass Spectrum Analysis;Massachusetts;Measures;Methods;Methylation;Minor;Monitor;Neurodegenerative Disorders;novel;Performance;Phosphorylation;Plasma;Post-Translational Protein Processing;protein expression;Proteins;Proteome;Proteomics;Research;Research Personnel;Resolution;Running;Sampling;Scanning;Technology;therapy resistant;Tissues;tool;Ubiquitination;United States National Institutes of Health

PROJECT_TITLE: A High Throughput and High Sensitivity Mass Spectrometer for Proteomics Studies on Human Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-T (30)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Insight into the 3D architectures of nucleic acids is essential for understanding their diverse roles in biotechnology and medicine, especially in the growing use of DNA and RNA vaccines and therapeutics. X3DNA-DSSR is a sophisticated, highly used software tool for the analysis, annotation, and visualization of 3D nucleic acid structures. The resource is employed in biomedical research and teaching in academic institutions and for the design of pharmaceuticals in industry.

PI_NAMEs: LU, XIANG-JUN  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 3-Dimensional;Applications Grants;Architecture;base;Bioinformatics;bioinformatics resource;Biology;Biomedical Research;Biotechnology;Case Study;Code;Communication;Communities;Dependence;design;Development;DNA;DNA Vaccines;DNA-Protein Interaction;Educational process of instructing;Funding;G-Quartets;Grant;Home Page;improved;Industry;insight;Institution;Internet;Journals;Knowledge;Libraries;Maintenance;Medicine;member;Mind;Nanotechnology;National Institute of General Medical Sciences;next generation;nucleic acid structure;Nucleic Acids;Paper;Peer Review;Pharmacologic Substance;Process;programs;Proteins;Publishing;R24;Reporting;Research;Resources;RNA;RNA vaccine;Role;Scientist;Services;Software Tools;spam;Standardization;structural biology;Structure;Therapeutic;three-dimensional visualization;tool;United States National Institutes of Health;usability;web app;web interface;Work;Writing

PROJECT_TITLE: X3DNA-DSSR: a resource for structural bioinformatics of nucleic acids

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 BBCB-U (NR)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: BATON ROUGE

ORG_DEPT: CHEMISTRY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project Narrative  The proposed research concerns the synthesis and evaluation of a glycoconjugate vaccine to be used for the prevention of infections caused by the bacteria Acinetobacter baumannii. A. baumannii is a major cause of hospital-related and combat-related infections resulting in serious illness and high rates of death. Because of an increasing incidence of drug resistance and because there is no approved vaccine for A. baumannii, novel and effective approaches to the prevention and treatment of infections that it causes are in demand.

PI_NAMEs: RAGAINS, JUSTIN ROBERT (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acinetobacter baumannii;adaptive immune response;adaptive immunity;Address;Antibodies;Antibody Formation;Antibody titer measurement;appendage;B-Lymphocyte Epitopes;Bacteria;Bacterial Infections;Binding;Carrier Proteins;chemical conjugate;chemical synthesis;Chemicals;Clinical;clinical implementation;clinically relevant;combat;cross reacting material 197;cytokine;Death Rate;design;Development;Diphtheria Toxin;Drug Metabolic Detoxication;Drug resistance;Ensure;Enzyme-Linked Immunosorbent Assay;Evaluation;Excision;experimental study;fitness;Flow Cytometry;Formulation;Glycoconjugates;Goals;Gram-Negative Bacteria;Haemophilus influenzae;Hospitals;Human;Immune response;Immune Sera;Immune system;Immune Targeting;Immunization;Immunize;immunogenicity;Immunologic Memory;Immunologics;Immunologist;Immunology;Incidence;Infection;Infection prevention;Injections;innovation;interest;Laboratories;Link;lipooligosaccharide;Memory B-Lymphocyte;Morbidity - disease rate;mortality;Multi-Drug Resistance;Mus;Nature;Neisseria meningitidis;novel;Oligosaccharides;Oximes;pathogen;Physicians;Polysaccharides;Prevention;Prevention approach;Production;protective effect;Recording of previous events;Reporting;Research;Scheme;Series;Serotyping;Streptococcus pneumoniae;Sulfhydryl Compounds;Sulfides;Surface;Survival Rate;T-Lymphocyte Epitopes;Vaccination;vaccination outcome;vaccine development;Vaccines;Virulence;Vulnerable Populations;Work

PROJECT_TITLE: Synthesis and Evaluation of a Bivalent Glycoconjugate Vaccine for Prevention of Infection with Acinetobacter baumannii

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This project will address fundamental questions about the mechanisms that process and repair single-stranded DNA gaps to maintain genome stability. We will achieve our goals by using unique single-molecule approaches available in the Vindigni lab. This knowledge is crucial for basic research to inform how cancer cells regulate the balance between mutagenic and error-free mechanisms of gap repair, and how targeting these mechanisms modulates chemotherapy response, particularly in the context BRCA1-deficient tumors.

PI_NAMEs: VINDIGNI, ALESSANDRO  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Affect;Basic Science;Biochemical;Biological;biological adaptation to stress;Biological Assay;BRCA deficient;BRCA1 gene;BRCA2 gene;cancer cell;Cancer-Predisposing Gene;Cells;Cellular Assay;chemotherapy;cohort;Collaborations;Coupling;Data;DNA;DNA biosynthesis;DNA Damage;DNA fiber assay;DNA lesion;DNA replication fork;Electron Microscopy;Equilibrium;Event;Excision;EXO1 gene;Fiber;Funding;Genome;Genome Stability;Genomic Instability;Goals;Impairment;In Vitro;innovation;insight;Knowledge;Lesion;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Mediating;Molecular;molecular modeling;Mutation;novel;novel strategies;nuclease;Oligonucleotides;Pathway interactions;Platinum;Play;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;prevent;Process;protein purification;reconstitution;repaired;replication stress;Resected;Resistance;response;Role;single molecule;Single-Stranded DNA;Structure;targeted treatment;Technology;Testing;Time;treatment response;tumor;Visualization;Work

PROJECT_TITLE: DNA replication stress in cancer

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Autoimmune Disease;Climate-Related Exposures and Conditions;Genetics;Lupus;Lymphatic Research

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: Narrative Patients with systemic lupus erythematosus and other autoimmune diseases can develop systemic disease flares upon even ambient sunlight, but the mechanisms are poorly understood. Here, we will examine the how the flow of information from skin to immune tissues via lymphatic vessels modulates skin and immune function.

PI_NAMEs: LU, THERESA T. (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Antigen-Presenting Cells;Antigens;Apoptosis;Autoantibodies;Autoimmune Diseases;Autoimmunity;Automobile Driving;B-Lymphocytes;Binding;CCL2 gene;Cell Physiology;Cells;Client;Communication;Data;Development;Disease;draining lymph node;epitranscriptomics;Exposure to;FDA approved;Flare;Gene Expression;Generations;Goals;Human;IFNAR1 gene;IL17 gene;Immune;immune function;Immune response;Immune system;Immunity;Immunize;immunoregulation;improved;in vivo;Inflammation;Inflammatory;Infrastructure;Injury;insight;Intercellular Fluid;Interferons;Interleukin-1;Life Style Modification;Link;Liquid substance;Lupus;lupus-like;Lymph;lymph flow;lymph nodes;Lymphatic;lymphatic circulation;lymphatic dysfunction;Lymphatic function;lymphatic vessel;Lymphoid Tissue;Manual Lymphatic Drainage;Mediating;Mediator;Messenger RNA;Modeling;Modification;monocyte;mouse model;Mus;NADPH Oxidase;Organ;organ injury;Patients;Phenotype;Photosensitivity;Plasmablast;programs;Quality of life;Reactive Oxygen Species;Reader;receptor;Regulation;Regulatory T-Lymphocyte;response;Reticular Cell;RNA;RNA-Binding Proteins;Role;sensor;Shapes;Signal Transduction;Skin;skin disorder;skin lesion;Stimulus;Stromal Cells;Sunlight;systemic autoimmunity;Systemic disease;Systemic Lupus Erythematosus;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;Transcript;Transgenic Model;Transplantation;Ultraviolet Rays;Up-Regulation;UV induced;UV Radiation Exposure

PROJECT_TITLE: Lymphatic regulation of lymph node function in lupus

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Nanotechnology

ORG_CITY: GOLDEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLORADO SCHOOL OF MINES

ORG_STATE: CO

PHR: Warming eyelids of Meibomian gland dysfunction (MGD) patients to increase oil flow is a common treatment but most commercial therapies heat eyelids from the outside, even though the glands are located close to the inner surface of the eyelids. We are proposing a novel approach for warming the eyelids from inside by designing gold nanoparticle loaded contact lenses (GoldInLens) which can be warmed by exposure to a low intensity light source due to surface plasmon resonance (SPR). The warming lens will be placed on a low thermal conductivity lens which will act as an insulator to minimize heat transfer to the cornea. 3

PI_NAMEs: CHAUHAN, ANUJ  (contact);KOMPELLA, UDAY B

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: absorption;Affect;Air;Animals;Anti-Inflammatory Agents;Burn injury;China;Colorado;common treatment;Contact Lenses;Cornea;Corneal Injury;Country;design;Development;Devices;Drug Delivery Systems;Dry Eye Syndromes;evaporation;experimental study;Exposure to;Eye;eye dryness;Eyelid structure;Film;Future;Generations;Gland;Goals;Gold;gold chloride;Heating;High temperature of physical object;Histologic;Home;In Situ;In Vitro;in vivo;India;Injury;Japan;lens;Light;light intensity;Lipids;Liquid substance;manufacture;manufacturing process;Massage;Measures;meibomian gland;meibomian gland dysfunction;melting;Monitor;nanoGold;novel;novel strategies;ocular surface;Oils;Oryctolagus cuniculus;Patients;Persons;Pharmaceutical Preparations;Phase;Physicians' Offices;Polymethyl Methacrylate;Prevalence;Procedures;professor;Radiation;Reporting;Research;Skin;sodium borohydride;Solid;Source;Structure of palpebral conjunctiva;success;Surface;Surface Plasmon Resonance;Symptoms;System;Taiwan;Temperature;Testing;Therapeutic heat application;Thermal Conductivity;Thermogenesis;Thinness;Time;Toxic effect;United States;Universities

PROJECT_TITLE: Unidirectional delivery of heat to the eyelid by GoldInLens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Cancer;Hematology;Hodgkin's Disease;Infectious Diseases;Lymphatic Research;Lymphoma;Prevention;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Narrative: Over 95% of adults are infected with gammaherpesviruses that are known to drive development of B cell lymphomas. Unfortunately, very little is known about the viral and host factors that influence the development of gammaherpesvirus-driven lymphomas. This proposal will determine how a classical antiviral factor of the host is usurped by gammaherpesviruses to establish life-long infection.

PI_NAMEs: TARAKANOVA, VERA L. (contact)

PROGRAM_OFFICER_NAME: LINDE, AMBER SHRYER

PROJECT_TERMS: Acute;Address;Adult;Animal Model;Anti-viral Agents;Attenuated;B cell differentiation;B-Cell Development;B-Cell Lymphomas;B-Lymphocytes;Biological;cell growth regulation;Chronic;chronic infection;Developed Countries;Development;Ensure;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Lymphoma;Friends;gammaherpesvirus;Generations;Genes;Genetic;Goals;Heart;Hodgkin Disease;Human;Human Herpesvirus 4;Human Herpesvirus 8;humanized mouse;Immunocompetent;Immunocompromised Host;Incidence;Individual;Infection;Infection Control;Innate Immune Response;insight;Integration Host Factors;Interferon Type I;Interferon-beta;Interferons;IRF3 gene;Knowledge;latent infection;Life Cycle Stages;Lymphoma;Lymphomagenesis;Macrophage;Malignant Neoplasms;Mediating;Memory B-Lymphocyte;Modeling;Molecular;monocyte;Mus;novel;pathogen;Pathogenesis;Persons;Physiological;Prevention;Proliferating;Reaction;response;Risk Factors;Rodent;Role;Signal Transduction;Species Specificity;Structure of germinal center of lymph node;System;Testing;transcription factor;Vaccines;Viral;Viral Genes;viral interferon regulatory factor;Viral Pathogenesis;Viral Proteins;Viral reservoir;Virus;Virus Diseases;virus host interaction;Virus Latency

PROJECT_TITLE: From friend to foe: proviral role of IRF-3 in chronic gammaherpesvirus infection

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: IOWA CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Environmental contaminants are ubiquitous and many cause significant harm to human health. In this proposal, we seek to discover contaminant interactions with living cells and elucidate the mechanisms that determine changes in normal cell functions.

PI_NAMEs: ROMAN, DAVID L. (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Adverse effects;ARNT gene;Biological;Biological Assay;Biological Process;Cell Line;Cell Physiology;Cells;Chemicals;Data;design;drug discovery;Environmental Pollutants;Future;G-Protein-Coupled Receptors;Health;high throughput screening;holistic approach;Homeostasis;Human;improved;Individual;innovation;insight;Intuition;Investigation;Knowledge;Ligands;Link;Lipids;Literature;Mediating;Mediator;Melatonin;Methodology;Methods;Modeling;Molecular;Normal Cell;novel;open source;Orphan;Outcome;Pathway interactions;Pharmacology;phthalates;Physiological;Physiological Processes;Physiology;Plasticizers;pollutant;Poly-fluoroalkyl substances;Polychlorinated Biphenyls;Process;quaternary ammonium compound;receptor;Reporting;Research;Research Support;Resources;screening;Signal Pathway;Signal Transduction;Specificity;Sphingolipids;Stress;success;System;Techniques;Technology;Testing;tool;Toxicology;Work;Xenobiotics

PROJECT_TITLE: Investigating environmental contaminant interactions on the GPCRome: an unexplored landscape of activity

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Narrative The proposed experiments will both provide IND-enabling data to support clinical evaluation of intrOv as a novel oral vaccine against CT infection in the human genital tract and reveal new mechanisms of transmucosal immunity induced by an oral vaccine.

PI_NAMEs: ZHONG, GUANGMING  (contact)

PROGRAM_OFFICER_NAME: HILTKE, THOMAS J

PROJECT_TERMS: Address;Animals;Antibiotic Therapy;Antibiotics;Antigen-Presenting Cells;Antigens;Attenuated;Attenuated Live Virus Vaccine;Attenuated Vaccines;Biological Assay;Biotechnology;CD4 Positive T Lymphocytes;Cells;Cervicitis;Chlamydia Infections;Chlamydia muridarum;Chlamydia trachomatis;Chlamydophila psittaci;Clinical;Clinical Trials;Colon;Cowpox;Cross Presentation;Cross Reactions;Data;Disease;Epitopes;Evaluation;experience;experimental study;FDA approved;Formulation;Future;Gastrointestinal tract structure;Genitalia;Gonorrhea;Human;human pathogen;Immune response;Immune system;Immunity;improved;Infection;Infertility;Legal patent;Letters;Licensing;Link;Lymphocyte;Lymphoid Cell;male;Mediating;Meningococcal vaccine;Microbe;Monitor;Monkeys;Mouse Strains;Mucosal Immunity;Mucous Membrane;Mus;Mycobacterium bovis;Mycobacterium tuberculosis;novel;Oral;oral vaccine;Pathogenicity;Pathology;phase I trial;Phenotype;pre-Investigational New Drug meeting;Predisposition;prevent;Production;recruit;Reporting;reproductive tract;research clinical testing;RNA vaccine;Safety;Sexually Transmitted Diseases;Smallpox;Subunit Vaccines;Testing;Texas;Toxicology;trachoma vaccine;Tuberculosis Vaccines;Universities;vaccine efficacy;Vaccines;vector vaccine;Water

PROJECT_TITLE: An oral vaccine against Chlamydia trachomatis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 KAR-M (J1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PHR: Project Narrative Decades of pharmacological work has shown that neuromodulators like dopamine and serotonin can affect the activity and output of the spinal cord to change movement, but it has been difficult to understand their natural functions and targets. We will measure where and when these neuromodulators are released in the spinal cord during locomotion, and use genetic tools to see exactly what types of neurons respond. We will also block the effects of these neuromodulators and study how movement is changed.

PI_NAMEs: BAGNALL, MARTHA W (contact);DOUGLASS, ADAM D;MCLEAN, DAVID ;MURRAY, JAMES ;TADROSS, MICHAEL R

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TITLE: Unmasking neuromodulatory control of locomotion

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-P (12)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE This proposal seeks funding for the purchase of a Nanostring CosMX SMI. This instrument is the preeminent instrument on the market for single-cell spatial -omics. Using this instrument, the positional context of transcriptional activity as well as proteins within cells in intact tissue can be assessed, leading to new insights in our understanding of cell-to-cell interactions and functional organization of tissue.

PI_NAMEs: JEPSEN, KRISTEN LYNN (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Area;Biomedical Research;California;cellular imaging;Clinical;Communities;Core Facility;Data;Disease;Ensure;Equipment;experience;Funding;Genomic medicine;Genomics;Health;Human;imager;Immunology;Inflammatory Bowel Diseases;innovation;Institution;Minor;Molecular;nano-string;Nerve Degeneration;Neurobiology;novel;Qualifying;Reproductive Sciences;Research;Research Personnel;Retinal Diseases;Services;single molecule;skills;Technical Expertise;Technology;Training;Translating;United States National Institutes of Health;Universities;wound healing

PROJECT_TITLE: Spatial Molecular Imager for Single Cell Imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE - OVERALL The New Mexico Alzheimer’s Disease Research Center (NM ADRC) is developed from our exploratory ADRC funded in 2020 that has been able to recruit a large, underrepresented population of Hispanics/Latinos (H/L) and American Indians (AI) for inclusion in national databanks. This is the ADRC between the Canadian and Mexican borders in the Rocky Mountain region in a state that lacks resources in its rural areas. Some of our strategies include use of a mobile MRI scanner and community health workers to obtain MRI and plasma-based biomarkers to test for early dementia in this rural population to determine those in need of further diagnostic testing and possible inclusion in future clinical trials. The outreach program in the NM ADRC will facilitate recruitment of minorities into studies, identify potential trainees, promote AD/ADRC research in New Mexico, and expand dementia care to otherwise inaccessible individuals of the state.

PI_NAMEs: ROSENBERG, GARY ALLEN (contact)

PROJECT_TERMS: Adult;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American Indian community;American Indians;Angiogenic Factor;Area;Automobile Driving;Biological Markers;Blood;Blood - brain barrier anatomy;blood-brain barrier disruption;Caring;Cities;Classification;Clinical Trials;cognitive disability;cognitive function;cohort;Collaborations;Communities;Community Health;Community Health Aides;Consultations;Country;data management;data repository;Dementia;dementia care;dementia risk;Development;Diagnosis;Diagnostic tests;Diffusion Magnetic Resonance Imaging;Disease;Early Diagnosis;Education;education research;Etiology;experience;Faculty;flexibility;frontier;Funding;Future;Geography;Goals;Grant;health care availability;health care disparity;Health Personnel;Health Sciences;Health Services Accessibility;Heterogeneity;Hispanic;Hispanic Populations;Image;Impaired cognition;improved;Individual;Inflammation;Inflammatory;Infrastructure;Latino;Latino Population;Liquid substance;Magnetic Resonance Imaging;Matrix Metalloproteinases;Measures;Medical;medically underserved;Medicine;Memory;Methods;Mexican;Minority;minority communities;Minority Groups;Minority Recruitment;mixed dementia;multimodality;Nerve Degeneration;neuroimaging;neuropathology;Neuropsychological Tests;neurovascular injury;New Mexico;news;next generation;novel;novel marker;older adult;Older Population;outreach;outreach program;pandemic disease;Participant;Pathogenesis;patient population;Patient Recruitments;patient screening;Patients;Plasma;Population Heterogeneity;Positioning Attribute;precision medicine;Preparation;prevent;Prevention;Process;programs;Proteins;Pueblo Race;recruit;Reporting;repository;Research;Research Infrastructure;Research Personnel;Resources;Risk;Risk Factors;Role;Rural;rural area;Rural Community;rural dwellers;rural healthcare;Rural Minority;Rural Population;rural setting;Science;Scientist;screening;Services;Site;Social Workers;statistics;System;Testing;Training;Underrepresented Minority;Underrepresented Populations;underserved minority;Underserved Population;United States National Institutes of Health;Universities;Validation;vascular contributions;Vascular Dementia;Vascular Diseases;vascular inflammation;vasogenic edema;white matter;Work;Zuni

PROJECT_TITLE: New Mexico Alzheimer's Disease Research Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health

PROJECT_TERMS: Address;Adherence;advanced dementia;Advisory Committees;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American Indian community;American Indians;Area;Award;Biological Markers;Blood specimen;blood-based biomarker;Brain;Canada;Caring;Center Core Grants;Chronic Kidney Failure;Classification;Clinical;Communities;Community Health;Community Outreach;Consultations;Contracts;Data;data submission;Dementia;dementia care;Development;diabetes risk;Diagnosis;diversity and inclusion;Education;Ensure;Ethics;Evaluation;Faculty;Feedback;Fostering;frontier;Funding;Goals;Grant;Guidelines;Health Resources;Health Sciences;Image;improved;Individual;Inflammation;Infrastructure;Laboratories;Latino;Machine Learning;Magnetic Resonance Imaging;Medical;Medical center;medically underserved;meetings;Memory;Methods;Mexico;minority communities;Minority Groups;Modeling;Monitor;neuropathology;Neuropsychological Tests;New Mexico;next generation;operation;Patients;Phase;Philanthropic Fund;Plasma;Policies;Population;Positioning Attribute;precision medicine;programs;Progress Reports;Pueblo Race;Recommendation;recruit;Reporting;repository;Research;Research Personnel;Resource Sharing;Resources;Risk;Role;Rural;rural area;Rural Community;rural Hispanic;Sampling;Science;Scientist;Services;Site;Social Workers;Source;symposium;telehealth;Training;Travel;Underrepresented Populations;underserved community;United States National Institutes of Health;Universities;urban setting;Validation;Work;Zuni

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: ADAIR, JOHN CHALMERS (contact)

PROJECT_TERMS: Address;Affect;Age;age related;Alaska Native;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indians;Animals;Behavioral Sciences;bilingualism;Biological Markers;biomarker validation;Blood Vessels;blood-based biomarker;blood-brain barrier disruption;brain health;Brain Pathology;cerebrovascular;Clinical;clinical center;Clinical Data;clinical heterogeneity;Clinical Markers;Clinical Research;cohort;Collaborations;Communication;Communities;comorbidity;Data;Dementia;Development;Diagnosis;Disease;Disparity;Education;education research;Effectiveness;Ensure;Epidemiology;Equity;Evaluation;experience;Feedback;Fostering;Functional disorder;Goals;health literacy;Healthcare;healthy aging;high risk;Hispanic;Hispanic Populations;Human;Image;imaging biomarker;Incidence;Individual;Inequity;Inflammation;Inflammatory;Injury;interest;Latino;Latino Population;Liquid substance;literacy;Literature;Longitudinal cohort;Magnetic Resonance Imaging;Measurement;Measures;Mentorship;mixed dementia;Multimodal Imaging;multimodality;National Institute of Neurological Disorders and Stroke;neuroinflammation;neuropathology;Neuropsychology;neurovascular unit;New Mexico;next generation;Not Hispanic or Latino;outreach;Participant;Pathologic;Pathology;Performance;Persons;Population;Population Heterogeneity;pre-clinical;Procedures;recruit;Research;Research Personnel;Research Project Grants;Research Support;Research Training;resilience;Risk;Risk Reduction;Role;Sampling;Severities;social culture;social disparities;social health determinants;Social Sciences;sociocultural determinant;Structure;symposium;Target Populations;Testing;Time;Training;training opportunity;Training Support;Translational Research;Validation;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;vascular injury;Work

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Brain Disorders;Clinical Research;Data Science;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: ERHARDT, ERIK BARRY (contact)

PROJECT_TERMS: Acceleration;Accountability;Address;Alzheimer's Disease;Alzheimer's disease related dementia;analytical tool;Applications Grants;Artificial Intelligence;Big Data;Biological;Biological Markers;Blood specimen;Blood Vessels;Brain;Brain imaging;career development;catalyst;Cerebrovascular Disorders;Clinical;Clinical Trials;Collaborations;Community Health;Complex;Conceptions;Data;Data Analyses;data anonymization;data harmonization;data management;data mining;data repository;Data Set;data sharing;Data Sources;deep learning;Dementia;dementia risk;Demographic Factors;design;Detection;Development;Diagnosis;Discipline;Disease Progression;DNA;Ensure;Extramural Research Program;fighting;forging;Fostering;Goals;Grant;Image;Image Analysis;Individual;Inflammatory;Life Cycle Stages;Liquid substance;Machine Learning;Manuscripts;Mathematics;Mentorship;Methods;Monitor;New Mexico;novel;novel strategies;Ownership;Participant;Pattern;Performance;Pilot Projects;pre-clinical;Preparation;Productivity;prognostic;programs;Protocols documentation;Pueblo Race;Regulation;Reporting;repository;Research;Research Design;Research Personnel;Resources;Sampling;Secure;skills;Source;Statistical Methods;statistical service;statistics;Structure;Testing;tool;Training;transmission process;Tribal Council;Tribes;Underrepresented Populations;United States Indian Health Service;Update;user-friendly;web site;Work;Zuni

PROJECT_TITLE: Data Management and Statistics Core