FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Aging;Palliative Care

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Research training is crucial for medical students because they need to observe and experience how modest contributions in the field of aging research interventions can bring about profound changes and can advance health care delivery and improve quality of life for older adults and their caregivers. We believe that participation of medical student trainees in a highly structured and mentored training program in aging research provides a positive introduction to the field and will lead many to leadership careers as clinician-scientists, assume academic leadership positions and serve as tireless advocates for older adults' overall well-being and care.

PI_NAMEs: ALDRIDGE, MELISSA DIANE;SORIANO, RAINIER P (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Advocate;Aging;Basic Science;career;Clinical;clinical care;clinical training;Consensus;Development;Foundations;Future;Future Generations;Geriatrics;Goals;Health;Health system;Healthcare;human old age (65+);Individual;interest;Knowledge;Lead;Leadership;Learning;Life;Medical Education;Medical Research;medical schools;Medical Students;Medicine;Mentors;Mentorship;Modernization;older adult;Palliative Medicine;peer coaching;Play;Population;Process;programs;Public Health;Records;Research;Research Contracts;research faculty;Research Methodology;Research Personnel;Research Project Grants;Research Training;Role;skills;Structure;student mentoring;student training;Students;success;System;Training;Training and Education;Training Programs

PROJECT_TITLE: Training Future Leaders in Aging Research


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: SAN ANTONIO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Narrative The work proposed in this study will determine the role of the abhydrolase domain containing 17B depalmitoylase (ABHD17B), a previous un-recognized enzyme in mammals, in the development of diet-induced inflammation and abdominal obesity, which will illuminate the molecular signaling pathways underlying the well-established connection between obesity and metabolic disease. Understanding the molecular mechanism of ABHD17B action and its role in mediating the anti-inflammatory function of adiponectin will provide unique insight into targetable pathways for therapy development. With rapid growth of an epidemic of obesity, the development of novel therapeutic approaches to obesity-related diseases is highly relevant to public health and to the NIH mission.

PI_NAMEs: DONG, LILY Q (contact);LEADBETTER, ELIZABETH ANN

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Acyltransferase;adipokines;adiponectin;Adipose tissue;Affect;Agonist;Anti-Inflammatory Agents;Antiinflammatory Effect;Apoptotic;Biochemical;Biological Assay;Cells;Central obesity;Chronic;Data;Development;Diet;Down-Regulation;Enzymes;Exhibits;Fatty Liver;Functional disorder;Genes;Genetic;Grant;Greater sac of peritoneum;Health;High Fat Diet;Homeostasis;Human;Immune;Immunology;Impairment;in vivo;Individual;Inflammation;Inflammatory;Injections;innovation;insight;Insulin;Insulin Resistance;Knockout Mice;Lecithin;Link;Lysophosphatidylcholines;Macrophage;Mammals;Mediating;membrane biogenesis;Mesentery;Metabolic;Metabolic Diseases;Metabolism;Mission;Molecular;mouse model;multidisciplinary;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;novel therapeutics;Obesity;Obesity associated disease;Obesity Epidemic;Organ;Organism;palmitoylation;Pathway interactions;Phagocytes;Phagocytosis;Phenotype;Physiological;Positioning Attribute;prevent;Proteins;proteostasis;Public Health;rapid growth;receptor;Regulation;Role;Scientist;selective expression;Signal Pathway;Signal Transduction;subcutaneous;systemic inflammatory response;Testing;therapy development;Tissue Expansion;tool;United States National Institutes of Health;Visceral;Work

PROJECT_TITLE: Adiponectin signaling and macrophage function

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Clinical Research;Infectious Diseases;Kidney Disease;Malaria;Neurosciences;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: Project narrative This K43 describes a career development plan for Dr Batte over 5 years to receive mentored research training, undertake critical courses and training to develop into an independent researcher. Dr Batte will delineate the mechanisms of kidney-related brain injury in severe malaria by determining the extent that AKI phenotypes are associated with biosignatures of brain injury and recovery. Further, Dr Batte will establish the extent that AKI and AKI phenotypes are associated with cerebral edema, and in addition define the association between neurobehavioral outcomes, brain injury biomarkers and AKI phenotypes

PI_NAMEs: BATTE, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;African;Award;Biological Markers;biosignature;blood-brain barrier disruption;Brain;Brain Edema;brain health;Brain imaging;Brain Injuries;career;career development;Cell Cycle Arrest;cell injury;Cerebral Edema;Child;Childhood;Childhood Injury;Chronic Kidney Failure;Clinical;clinical diagnosis;college;Coma;Communities;Creatinine;Data;Data Analyses;Detection;Development;Development Plans;Diagnosis;disability;early childhood;education planning;Endothelium;Epidemiology;Evaluation;evidence base;Fever;Filtration;Fogarty International Center;follow-up;Funding;Future;Goals;Growth and Development function;Health Sciences;Hospitalization;Image Analysis;immune activation;improved;Injury;Injury to Kidney;Intervention;Intervention Studies;Kidney;Kidney Diseases;Knowledge;Lead;Learning;lecturer;life span;Link;Longitudinal Studies;Magnetic Resonance Imaging;Malaria;Malnutrition;Mentors;mortality;National Institute of Neurological Disorders and Stroke;neurobehavioral;Neuroglia;Neurological outcome;Observational Study;Osmolar Concentration;Outcome;Pathogenesis;Pathway interactions;Patients;Phenotype;Physicians;Plasma;point of care testing;Population;Positioning Attribute;predictive marker;prevent;Problem behavior;prospective;Publishing;Recovery;Research;Research Personnel;Research Training;Risk Factors;Sampling;Scientist;Serum;Sickle Cell Anemia;Site;skills;Stress;Stroke;Structure;Teacher Professional Development;Testing;Time;tool;Training;Translating;United States National Institutes of Health;Universities;Urea;Work

PROJECT_TITLE: Delineating the kidney brain axis in children with severe malaria (KID-BRAIN)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-J(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARATIVE Atrial Fibrillation is the most common type of cardiac arrhythmia in clinical practice, with a projected rise in prevalence and increased economic burden due to its complications. Our proposed studies will help determine how transcription factors regulate cardiac excitability, advancing our mechanistic understanding of the genetic susceptibility to cardiac arrhythmias. This project is relevant to the NIH mission because it will lay the foundation for future development of new therapeutic approaches to atrial fibrillation

PI_NAMEs: TORRES, NATALIA  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Action Potentials;Active Learning;Acute;Adolescent;Adrenergic Agents;Adult;Animal Model;Arrhythmia;ATAC-seq;Atrial Fibrillation;Automobile Driving;autosome;Award;Calcium;Cardiac;Cardiac Myocytes;Cardiovascular system;career;career development;Cell Nucleus;Cells;Chromatin;Chronic;Clinical;clinical practice;CRISPR/Cas technology;Data;Development;Down-Regulation;Economic Burden;Electrophysiology (science);Event;Family;Fishes;Foundations;Functional disorder;Funding;Future;Gene Deletion;Gene Silencing;Genes;Genetic Predisposition to Disease;Genetic Transcription;genetic variant;Genomics;Goals;Healthcare Systems;Heart;Heart Atrium;Heart Diseases;Heart failure;Heritability;Homeostasis;Hospital Costs;Human;human induced pluripotent stem cells;Individual;induced pluripotent stem cell derived cardiomyocytes;insight;Ion Channel;Knowledge;Leadership;Link;Maintenance;Maps;Measures;Mediating;Mentors;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;multiple omics;novel;novel therapeutic intervention;Optics;Output;Pathogenesis;Pathway interactions;Patients;pharmacologic;Predisposition;Prevalence;Principal Investigator;Property;Regulation;Regulatory Pathway;Research;Research Activity;response;Risk;Role;Sarcoplasmic Reticulum;Secure;Signal Transduction;single-cell RNA sequencing;skills;Small Interfering RNA;Stress;stressor;Stroke;Sudden Death;Susceptibility Gene;Tachyarrhythmias;targeted treatment;Testing;therapeutic target;therapeutically effective;Transcript;transcription factor;transcription factor USF;transcriptional reprogramming;transcriptome sequencing;Transgenic Organisms;Tretinoin;United States National Institutes of Health;Western Blotting;Zebrafish

PROJECT_TITLE: A novel regulator of Ca2+ homeostasis and arrhythmia susceptibility


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Urologic Diseases;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Stress urinary incontinence is the most common female pelvic floor disorder encountered in clinical practice with significant negative impact on quality of life. The prevalence of urinary incontinence increases with aging, and weakness of the pelvic floor muscles contributes to the development of stress urinary incontinence. Given that androgen receptors are expressed throughout the pelvic floor, the anabolic effects of androgens on pelvic floor muscles may provide a therapeutic option in women with stress urinary incontinence. We propose a randomized, double-blind, placebo-controlled proof-of-concept trial in older postmenopausal women with stress urinary incontinence to assess whether testosterone therapy can increase pelvic floor muscles and improve urinary function.

PI_NAMEs: BHASIN, SHALENDER  (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: abdominal pressure;Affect;Age;Aging;Anabolic Agents;Androgen Receptor;androgen sensitive;Androgen Therapy;Androgens;Animals;Area;Bladder;Bladder Control;Body Composition;Caring;clinical practice;Clinical Trials;comparative efficacy;comparison control;Coughing;Data;Development;Disease;Distress;Dose;Double-Blind Method;effective therapy;efficacy evaluation;Elderly;Electromyography;Equipment and supply inventories;Exertion;Experimental Animal Model;Experimental Models;Extravasation;Fascia;Female;Foundations;Functional disorder;Genitourinary system;Goals;Health;Hormonal;Hormonal Change;Human;Hysterectomy;improved;Incontinence;incontinence symptom;indexing;innovation;Intervention;Intra-abdominal;lean body mass;levator ani muscle;Lifting;Ligaments;Lower urinary tract;Magnetic Resonance Imaging;Measures;medication administration;Menopause;Mission;Muscle;Muscle Contraction;muscle form;muscle strength;Observational Study;older women;Operative Surgical Procedures;Organ;Outcome;Patient Self-Report;Patients;Pelvic Floor Disorders;Pelvic Floor Muscle;Pelvic floor structure;Pelvis;Performance;Physical Function;Pilot Projects;pilot trial;Placebo Control;Placebos;Play;Polycystic Ovary Syndrome;Postmenopause;pre-clinical;Pre-Clinical Model;pressure;Prevalence;Public Health;Quality of life;Quality of Life Assessment;Questionnaires;Randomized;randomized trial;Randomized, Controlled Trials;recruit;response;Role;Sexual Dysfunction;Skeletal Muscle;Sneezing;Sphincter;Stress;Stress Urinary Incontinence;Structure;Supplementation;Symptoms;Testing;Testosterone;Therapeutic;Training;United States;Urethra;Urethral sphincter;urinary;Urinary Incontinence;Urinary tract;Urination;Urine;Urodynamics;Woman;women patients;Women's study;women's treatment

PROJECT_TITLE: A Pilot Study to Evaluate the Anabolic Effect of Testosterone on Muscles of the Pelvic Floor in Older Women with Stress Urinary Incontinence

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE: Non-small cell lung cancer (NSCLC) leads to more cancer death annually than any other cancer, and despite the landmark approval of anti-PD-1 therapy for NSCLC, the majority of patients still have progressive disease. The IL-6/STAT3 pathway has been identified in association with decreased response to anti-PD-1 therapy in NSCLC patients, but the mechanism by which IL-6 leads to anti-PD-1 resistance is poorly understood. This proposed study will advance our basic understanding of IL-6-mediated anti-PD-1 resistance, and inform future combination therapy development in NSCLC for patients that have not responded to anti-PD-1 therapy.

PI_NAMEs: SOMASUNDARAM, ASHWIN  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Advisory Committees;Animal Model;anti-PD1 therapy;Binding;Biological Assay;Biological Markers;Blood;Cancer Etiology;Cancer Patient;Carcinogens;CD8-Positive T-Lymphocytes;Cell Physiology;Cessation of life;Coculture Techniques;cohort;Combined Modality Therapy;cytokine;cytotoxic CD8 T cells;Data;design;Disease Progression;Drug resistance;early phase clinical trial;Ensure;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;experience;Flow Cytometry;Formalin;Freezing;Functional disorder;Funding;Future;Gene Activation;Goals;IL6 gene;IL6ST gene;Immune;immune checkpoint blockade;Immunohistochemistry;Immunologist;Immunotherapy;In Vitro;in vivo;Infiltration;Interleukin-6;International;Ketones;Link;Lymphocyte Activation;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;meetings;Mentors;Modeling;Monitor;mouse model;Mus;Nicotine;Nitrosamines;Non-Small-Cell Lung Carcinoma;North Carolina;novel;Paraffin Embedding;Pathway interactions;Patients;PD-1 blockade;Peripheral;Physicians;Plasma;pre-clinical;predictive marker;prevent;Production;programmed cell death protein 1;Progressive Disease;Proliferating;Prospective cohort;Proteins;Research;Research Personnel;Resistance;resistance mechanism;Resources;responders and non-responders;response;response biomarker;Role;Sampling;Scientist;Signal Pathway;skills;Stat3 protein;systemic inflammatory response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;tenure track;therapy development;transcription factor;transcriptome sequencing;tumor;tumor growth;tumor immunology;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: The role of IL6-induced LAG3 as a resistance mechanism to PD1 blockade in NSCLC patients

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Emergency Care;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: SEATTLE

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Because Emergency Medical System providers (EMS) are first to arrive at the scene of an overdose and are critical partners in care for people who use drugs, we partnered with them, people who use drugs, and EMS leadership to collect pilot data and then co-design EMS-delivered interventions to reduce stigma and increase access to care for people who use drugs. These interventions are being rolled out as the EMS Overdose Prevention Project (EMS-OPP), and hold great potential to reduce racial disparities in access to evidence-based medical services and to improve long-term outcomes. Guided by Public Health Critical Race Praxis, we will study the impact of EMS-OPP on the experiences and outcomes of EMS encounters for overdose survivors who are Black, Hispanic/Latinx and American Indian/Alaskan Native to inform future policy and interventions to improve equitable care. 1

PI_NAMEs: VAN DRAANEN, JENNA  (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: access disparities;Address;Adopted;Affect;Alaska Native;American Indians;Black Populations;Black race;buprenorphine treatment;care providers;Caring;Cessation of life;cohort;combat;Communities;community intervention;community partners;County;Critical Race Theory;Data;Data Linkages;Data Management Resources;Death Rate;design;Disadvantaged;Discrimination;Disparity;Drug usage;Drug user;effectiveness evaluation;effectiveness/implementation study;Emergency medical service;Equity;Evaluation;evidence base;Evidence based intervention;experience;Fentanyl;fentanyl test;follow-up;Funding;Future;Health;Health Services Accessibility;Hispanic;Hispanic Populations;improved;Information Systems;Institution;Interruption;Intervention;Interview;Investigation;Jail;journal article;Latinx;Leadership;Link;Lived experience;Medical;Medical emergency;Methods;Naloxone;National Institute of Drug Abuse;Native-Born;Natural experiment;Opioid;opioid epidemic;opioid mortality;Outcome;outcome disparities;Overdose;overdose death;overdose prevention;Overdose reversal;Patient-Focused Outcomes;Patients;peer;people of color;perceived discrimination;Persons;Policies;Population;posters;prescription monitoring program;prevent;programs;Prospective cohort;Provider;Public Health;Race;racial disparity;racial health disparity;racial identity;racial population;Records;recruit;Research;Research Design;Research Personnel;response;Scientist;Series;Services;social stigma;State Government;stem;Stigmatization;Structural Racism;Structure;substance use;substance use treatment;Survivors;symposium;System;test strip;Time;Training;training project;Translations;Trauma;Work

PROJECT_TITLE: Assessing the Population-level and Equity Impact of the Emergency Medical Services Overdose Prevention Project (EMS-OPP) Using Critical Race Theory


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Transplantation

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Fuchs corneal endothelial dystrophy (FECD) is a blinding disease that affects millions of people each  year in the United States. Corneal transplantation is the common treatment for this condition. In the  current proposal, I outline experiments to identify and characterize the molecular mechanisms that lead to  disease progression in FECD with the objective of identifying therapeutics.

PI_NAMEs: SHYAM, RAJALEKSHMY  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Affect;Age;aging population;Alternative Therapies;Animal Model;Bilateral;Cell Line;Cells;Characteristics;common treatment;Corneal edema;Corneal Endothelium;Data;Development;Diabetes Mellitus;Disease;Disease Progression;Drug Targeting;Endothelial Cells;Endothelium;experimental study;Failure;Fuchs' Endothelial Dystrophy;Functional disorder;Genes;Graft Rejection;Infection;Integrin Signaling Pathway;Integrins;Keratoplasty;Knockout Mice;Malignant Neoplasms;Mesenchymal;Molecular;mouse model;Mus;Mutate;Mutation;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;Persons;Pharmacologic Substance;Phenocopy;Phenotype;Physiologic Intraocular Pressure;Repression;Role;Signal Pathway;Signal Transduction;standard care;Testing;Therapeutic;Tissue Donors;United States;WNT Signaling Pathway

PROJECT_TITLE: Molecular Dysregulation in Fuchs Corneal Endothelial Dystrophy

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Prevention

ORG_CITY: CLAREMONT

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CLAREMONT GRADUATE UNIVERSITY

ORG_STATE: CA

PHR: Diversifying the biomedical workforce is imperative to meet the healthcare needs of the U.S. population. We will build on our established longitudinal panel of Black and Hispanic science majors to test the long-term effectiveness of two widely utilized interventions: undergraduate research experience and faculty mentorship. Results will inform best practice for these large- scale interventions in training the next generation of diverse biomedical researchers.

PI_NAMEs: HERNANDEZ, PAUL R;SCHULTZ, PAUL WESLEY;WOODCOCK, ANNA  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Biomedical Research;biomedical scientist;Black race;career;Career Choice;college;comparison group;Data;design;Doctor's Degree;dosage;Educational Intervention;Effectiveness;Effectiveness of Interventions;effectiveness testing;efficacy testing;Elements;Equilibrium;ethnic identity;evidence base;experience;Faculty;follow-up;Funding;Future;graduate school;Healthcare;Hispanic;improved;insight;Intervention;Life;Longitudinal Studies;Mediating;Mentorship;Methodology;next generation;Personal Satisfaction;Population;post-doctoral training;Productivity;prospective;Race;Research;Research Personnel;Role;satisfaction;Science;Scientist;student retention;Students;success;Testing;Training;Training Programs;Treatment Efficacy;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Research Experience and Mentorship as Critical Interventions to Advance Diversity in Biomedical Science


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lymphatic Research;Neurosciences;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: AMES

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Project Narrative Filarial nematodes, Brugia malayi, B. timori, and Wuchereria bancrofti, cause lymphatic filariasis that affects millions of people in the tropical regions of the world. The chronic infections result in characteristic painful swelling of the limbs (elephantiasis) and later lymphedema of the genitals. The associated irreversible physical disability and profound disfiguring cause substantial economic, social, and psychological damage. Mass drug treatment with anthelmintic medicines is recommended to interrupt the transmission cycle of filarial infection. Chemotherapy effectively clears microfilariae from the host and suppresses their reappearance, but they have limited adulticidal activity. Inhibitory GABA-gated chloride channels present at the neuromuscular junction of nematodes are a vital mediator of locomotion. They serve as a target for only one nematocidal compound, piperazine, and have not been explored in filarial nematodes. unc-49 encodes for a GABA receptor in nematodes that mediates contralateral body muscle inhibition during locomotion. UNC-49 GABA channel has been characterized from Caenorhabditis elegans and Haemonchus contortus. These receptors are pharmacologically distinct from vertebrate channels and display species-based diversity. We will explore the biological significance and potential of Bma-UNC-49 channels as a novel drug target. This project will characterize the filarial UNC-49 receptors providing a better understanding of its pharmacology and the molecular basis of the activity of selective GABA channels. This proposal will have implications for identifying the molecular basis of the activity of GABA channel activators, exploring selective drugs, and contributing to the development of novel macrofilaricidal compounds in the future.

PI_NAMEs: CHOUDHARY, SHIVANI  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Adult;Affect;Africa South of the Sahara;Agonist;Albendazole;antagonist;Anthelmintics;Antiparasitic Agents;Appearance;behavioral study;Biological;Biological Process;Biology;Brugia malayi;Caenorhabditis elegans;Cell Line;Characteristics;chemotherapeutic agent;chemotherapy;Child;Childhood;Chloride Channels;Chlorides;Chronic;chronic infection;Citrates;Cloning;Contralateral;Country;Culicidae;Data;Dedications;Development;Diethylcarbamazine;disease transmission;Drug resistance;drug resistance development;Drug Targeting;Economic Development;Economics;Electrophysiology (science);Elephantiasis;Exhibits;experimental study;Filaria bancrofti;Filarial Elephantiases;Filariasis;Future;GABA Receptor;GABA-A Receptor;gamma-Aminobutyric Acid;Genes;Genitalia;Haemonchus;Human;in vivo;Infection;Infectious Skin Diseases;insight;Interruption;Invertebrates;Ion Channel;Ion Channel Gating;Ivermectin;knock-down;Ligands;Limb structure;Locomotion;lymphadenopathy;Lymphatic;lymphatic drainage;lymphatic dysfunction;Lymphatic System;Lymphedema;Mediating;Mediator;Medicine;Methods;Molecular;mosquito-borne;Movement;Muscle;Muscle Contraction;Muscle relaxation phase;neglected tropical diseases;Nematoda;nerve supply;Neuromuscular Junction;Neurotransmitters;new therapeutic target;novel;Obstruction;Pain;Paralysed;Parasites;Parasitic infection;Parasitic nematode;Pathologic;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Phenotype;physically handicapped;Physiological;Piperazines;Potassium Channel;Poverty;Productivity;Property;Protein Isoforms;Psyche structure;psychologic;receptor;Recommendation;Research;response;RNA Interference;RNA Splicing;Role;Side;social;Southeastern Asia;Stress;Swelling;System;Techniques;Testing;Therapeutic;therapeutic target;transmission process;vaccine access;Variant;Xenopus oocyte

PROJECT_TITLE: A functional characterization of Brugia malayi GABA-gated chloride channels: an unexplored target for antifilarial therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: KANSAS CITY

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative The proposed research is relevant to public health because acquired brain injuries, such as stroke, leave many Americans with chronic motor disabilities, requiring long-term care. This project seeks to understand the role that premotor cortex, an area suggested to be involved in functional recovery, plays in motor rehabilitation following acquired brain injuries. The results will provide critical information needed to inform how rehabilitative strategies alter brain structure and function and ultimately leading to novel therapies and improved motor outcomes following stroke.

PI_NAMEs: GUGGENMOS, DAVID  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Affect;Agonist;American;Anatomy;Animal Model;Animals;Area;Basic Science;Behavioral;behavioral outcome;Bilateral;Brain;Brain Injuries;Brain region;Chronic;Clinical;Continuous Infusion;Coupled;critical period;Distant;experience;Functional impairment;GABA-A Receptor;Goals;Health;hemiparesis;Implant;improved;in vivo;Individual;Injury;injury recovery;innovation;Intervention;ischemic injury;Left;Lesion;Location;Long-Term Care;Measurement;Measures;Mediating;Medical Care Costs;medical complication;Microelectrodes;Modeling;Motor;Motor Activity;motor control;Motor Cortex;Motor disability;motor disorder;motor function recovery;motor impairment;motor recovery;motor rehabilitation;Movement;Muscimol;muscle strength;neural;neural tract;neurite growth;Neuronal Plasticity;Neurons;novel;novel therapeutics;Outcome;Performance;Persons;Physiological;Play;Population;post stroke;pre-clinical;Process;Public Health;Quality of life;Rattus;Recovery;Recovery of Function;Rehabilitation therapy;Research;research study;response;Role;Science;Shapes;skills;somatosensory;Speed;Spinal Cord;Stroke;Structure;Time;Tracer;Training;Translating;United States

PROJECT_TITLE: The contribution of premotor cortex to recovery after stroke.

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Mental Health;Obesity;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Given the strong link between education and health, improving schools and educational outcomes may be a potentially effective public health intervention. In 2013, we initiated a longitudinal natural experiment to study the impact of exposure to high-performing schools on adolescent health and found significant improvements in self-reported health among males, but worse health among females. We propose to continue this cohort study and follow subjects through age 28, examining males and females in physiologic health outcomes, stress, socioemotional factors, and resilience.

PI_NAMEs: WONG, MITCHELL DAVID (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: 21 year old;Admission activity;Adolescence;Adolescent;adolescent health;Adult;Affect;Age;Aging;Alcohol consumption;Alcohol dependence;alcohol use disorder;Anti-viral Response;Anxiety;Biological Aging;Biological Assay;Biological Markers;Blood Pressure;Blood specimen;Body mass index;C-reactive protein;Characteristics;Chronic stress;Cognitive;cognitive skill;cohort;Cohort Studies;college;Decision Making;Development;DNA Methylation;early childhood;Education;educational atmosphere;emerging adult;emotional factor;epigenetic aging;experience;Experimental Designs;experimental study;Exposure to;Family;Feeling hopeless;Female;fighting;follow-up;Follow-Up Studies;Future;gender difference;Gene Expression Profile;Genetic Transcription;graduate school;Hair;Health;Health behavior;Health Insurance;Healthcare Systems;high school;Hydrocortisone;Improve Access;improved;Inequity;Inflammation;Interferon Type I;Intervention;Knowledge acquisition;Life Cycle Stages;Link;literacy;male;mathematical ability;matriculation;Measures;Mediating;Mental Depression;Methods;mortality;Natural experiment;Neighborhoods;Neurobiology;Obesity;Observational Study;Outcome;Outcome Measure;Overweight;Participant;Patient Self-Report;peer;Personal Satisfaction;physical conditioning;Physiological;Policies;Poverty;Process;Public Health;public health intervention;public health relevance;Quality of Care;Randomized;rate of aging;Relative Risks;Reporting;resilience;Resources;response;retention rate;Risk Reduction;Role;school environment;Schools;Secondary Schools;Self Care;Sex Differences;Shapes;Signal Transduction;social;Social Network;socioeconomics;Standardization;Stress;Student recruitment;Students;substance use;Substance Use Disorder;Sympathetic Nervous System;teacher;Testing

PROJECT_TITLE: A natural experimental study of the impact of education on physiologic health, stress, and resilience and the role of socioemotional factors.

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Variants in the mitochondrial genome cause a range of disease in humans, ranging from severe pediatric syndromes to aging-related disease. Unlike the nuclear genome, the mitochondrial genome is present in hundreds to thousands of copies in a cell and hence, a cell may contain mitochondrial genomes with and without a disease-causing variant. Our study will evaluate whether mitochondrial genetic variants differ across the tissues of the human body and whether those variants arose during development or later in life.

PI_NAMEs: FETTERMAN, JESSICA L (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Adult;Affect;Age;age related;aging related disease;Autopsy;Benign;Biogenesis;Biology;Biopsy;Blood specimen;Brain;Cardiovascular Diseases;Catalytic Domain;Cell Cycle;Cell Differentiation process;cell type;Cells;Cessation of life;Childhood;Complex;Data;Data Set;Defect;Development;Diagnosis;Diagnostic;Disease;disease-causing mutation;Ectoderm;Endoderm;Enzymes;Exclusion;Future;Gene Frequency;General Population;Genes;Genetic;genetic epidemiology;genetic variant;Genetic Variation;Genome;genome sequencing;Genotype-Tissue Expression Project;Germ Layers;Heart;Hematopoietic;heteroplasmy;Human;human disease;Human Genome;human induced pluripotent stem cells;human tissue;Individual;Inherited;insight;Life;Mesoderm;Metabolism;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial genome;Mutation;Neurodegenerative Disorders;Nuclear;Oxidative Phosphorylation;Pathogenicity;Patients;Phase;Phenotype;Population;precursor cell;Publications;RNA Folding;Site;Skeletal Muscle;Syndrome;Time;tissue mosaicism;Tissues;transcriptome sequencing;transmission process;Variant;whole genome

PROJECT_TITLE: Mitochondrial Genetic Variation Across Human Tissues

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Clinical Research;Disability Research;Kidney Disease;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative People with all stages of chronic kidney disease (CKD) are at increased risk of poor physical functioning, but the burden and risk factors for physical function decline and its relationship to clinical outcomes in adults with non-dialysis dependent CKD has been under-studied. We propose to inform CKD clinical practice by determining the prognostic importance of physical function over time among persons with CKD, including insights to risk factors of physical function decline, and building a clinical tool to monitor physical function that could guide treatment and prognostic decisions, while identifying patients most likely to need further services. Ultimately, the proposed study will guide how patients with CKD are monitored in clinical care, inform patient-centered treatments, and promote broad improvement in physical function for this high-risk population by catalyzing greater awareness and targeted interventions.

PI_NAMEs: SCHRAUBEN, SARAH JEANNE (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Adult;adverse outcome;Age;Assessment tool;Awareness;Body Composition;Caring;Cessation of life;Characteristics;Chronic Kidney Failure;Chronic Kidney Insufficiency;Clinical;clinical care;clinical practice;Clinical Practice Guideline;cohort;Cohort Studies;Data;Decision Making;disability;Disability prevention;Disease;Early Diagnosis;Early Intervention;Eligibility Determination;Ensure;evidence base;Fatty acid glycerol esters;follow-up;Foundations;frailty;functional decline;functional status;General Population;Glomerular Filtration Rate;Goals;Health;High Prevalence;high risk population;Hospitalization;improved;improved outcome;Independent Living;insight;Intervention;Intervention Trial;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;low socioeconomic status;Measures;modifiable risk;Monitor;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;older adult;Outcome;Participant;Pathway interactions;Patient Monitoring;patient oriented;Patient Outcomes Assessments;Patient Self-Report;Patients;Performance;performance tests;Persons;Physical assessment;physical conditioning;Physical Function;physical impairment;Physical Performance;Population;Population Heterogeneity;Premature Mortality;prevent;Prognosis;prognostic;Quality of life;Recommendation;Replacement Therapy;Reporting;Research;Risk;Risk Factors;risk stratification;screening;Self Management;Services;social health determinants;Testing;therapy development;Time;tool;treatment center;Update;Work;young adult

PROJECT_TITLE: Physical Function in Chronic Kidney Disease: Characterizing the Natural History and Relationship to Clinical Outcomes

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project narrative: This study will test whether a brief, behavioral treatment program can help vulnerable youths struggling with depression and anxiety. A previous face-to-face version of this program was effective, and this study will test to see if the program works well when delivered in a telehealth format to families who are traditionally underserved by mental health. Results may help move effective treatments for these serious problems into widespread community practice.

PI_NAMEs: LYNCH, FRANCES L;WEERSING, V ROBIN (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: acceptability and feasibility;Adopted;Affect;Aftercare;Age;Anxiety;Anxiety Disorders;anxiety treatment;anxious;Area;arm;avoidance behavior;Behavior Therapy;Behavioral;Caring;Clinic;Clinical;Clinical effectiveness;Communities;Community Mental Health Services;Community Practice;Community Surveys;comorbidity;Consolidated Framework for Implementation Research;cost effective;cost effectiveness;cost estimate;cost per quality-adjusted life year;Data;Depressed mood;Development;Diagnostic;digital health;Disadvantaged;Disease;disparity reduction;effective therapy;Effectiveness;effectiveness testing;effectiveness-implementation randomized trial;effectiveness/implementation study;Electronic Health Record;Eligibility Determination;Etiology;evidence base;experience;Face;Family;follow-up;Functional impairment;Funding;Future;future implementation;health care disparity;health service use;Housing;Hybrids;Impairment;implementation efforts;implementation evaluation;implementation framework;Implementation readiness;implementation trial;improved;incremental cost-effectiveness;innovation;Intake;Intervention;Interview;Language;Latinx;Lead;Leadership;Masks;Mediating;Mental Depression;Mental Health;Mental Health Services;minority children;Modeling;Modification;Mood Disorders;Neighborhood Health Center;Outcome;Patients;Pediatrics;Pilot Projects;Population;Population Heterogeneity;Predictive Factor;Primary Care;primary care setting;Process;programs;Provider;public health priorities;Quality of Care;Randomized;Readiness;recruit;Recurrence;Reporting;Resource-limited setting;Resources;response;Risk;safety net;Sampling;Site;social health determinants;Spanish;Suicide;Surveys;Technology;telehealth;Testing;tool;Translations;treatment program;treatment research;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Behavioral telehealth in low-resource primary care settings for anxiety and depression in youth: A randomized effectiveness-implementation study

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The Analysis, Visualization, and Informatics Lab-space (AnVIL) is a cloud-based computing platform that brings together genomics resources and broad access to genomics datasets to enhance collaboration across research teams. The AnVIL Clinical Environment for Innovation and Translation (ACE-IT) team will amplify the existing AnVIL platform by first engaging with diverse partners to characterize barriers to clinical genomics research on cloud environments integrating tools that enable clinical genomics research methods. The team will then work with existing AnVIL teams and partners to integrate diverse datasets and implement clinical genomics tools to support the rapidly evolving field of clinical and translational genomics research.

PI_NAMEs: CARROLL, ROBERT J (contact);LEBO, MATTHEW S

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Adopted;Adoption;All of Us Research Program;American Heart Association;Biomedical Research;Breast Cancer Risk Factor;Cancer Control;cancer prevention;Capital;Clinical;Clinical Research;cloud based;Cloud Computing;Collaborations;Collection;Communities;Complex;computational platform;computing resources;Cost Control;Data;data integration;data resource;Data Science;Data Set;data space;design;Development;Diagnosis;Disease;disease diagnosis;diverse data;Ecosystem;Electronic Medical Records and Genomics Network;Environment;Equity;evidence base;Family;Foundations;Funding;General Hospitals;Genome;genome resource;genome sciences;genomic data;genomic tools;Genomics;Growth;hazard;Health;health care settings;Health Disparities Research;Health Resources;Healthcare;Hospitals;improved;indexing;Individual;Informatics;informatics tool;Infrastructure;Ingestion;innovation;Investments;Knowledge;Libraries;Massachusetts;meetings;member;Methods;Mission;National Human Genome Research Institute;new technology;novel;Outcome;Patient Care;Persons;Pharmacogenomics;phenotypic data;polygenic risk score;Population;Population Heterogeneity;Process;Rare Diseases;Recording of previous events;Research;Research Methodology;Research Personnel;Resources;Risk;Risk Assessment;Risk Factors;Security;Services;social health determinants;Stream;support tools;System;Technology;Time;tool;Training Support;translational approach;translational genomics;Translational Research;Translations;United States National Institutes of Health;Visualization;Woman;Work;working group


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: WISTAR INSTITUTE

PHR: Project Narrative – Overall Melanoma is a devastating disease, with increasing incidence worldwide. Although remarkable progress has been made treating melanoma, more than 60% of patients do not achieve long-term benefit. The central goal of this program is to develop functional personalized combination therapies to combat tumors that are resistant to current therapies. These studies are possible because we have a large bank of >500 melanoma patient derived xenografts which have been characterized based on DNA- and RNA-sequencing, and protein expression. We aim at matching novel combination therapies with the right patient based on the individual tumor profile; the knowledge obtained from these studies will be critical to prioritize clinical testing of novel combination therapies to improve patient’s outcomes.

PI_NAMEs: DAVIES, MICHAEL ;HERLYN, MEENHARD F;VILLANUEVA, JESSIE  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acral Lentiginous Malignant Melanoma;advanced disease;Back;Behavior;bench to bedside;Bioinformatics;Biologic Characteristic;Biological;Biology;biomarker identification;BRAF gene;Cataloging;Clinical;Clinical Trials;Collaborations;Collection;combat;combinatorial;Combined Modality Therapy;Communities;Cutaneous Melanoma;Data;design;Development;Disease;DNA Integration;DNA sequencing;Drug Combinations;Drug resistance;early phase clinical trial;efficacious treatment;Evaluation;Exhibits;exome sequencing;FDA approved;Fostering;Funding;Genetic;Genetic Drift;Genetic Heterogeneity;Goals;Grant;Heterogeneity;Histologic;Human;Immunotherapy;improved;improved outcome;Incidence;Individual;inhibitor;innovation;Institution;Investigational Drugs;Knowledge;Laboratories;Malignant Neoplasms;Maps;MEKs;Melanoma;Melanoma patient;Modeling;Molecular;Molecular Profiling;mucosal melanoma;multidisciplinary;mutant;Mutation;novel;novel therapeutic intervention;novel therapeutics;Organoids;Paper;patient derived xenograft model;Patient Selection;patient subsets;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase;Phenotype;Pilot Projects;pre-clinical;Pre-Clinical Model;Precision therapeutics;preclinical study;preclinical trial;prevent;programs;Property;Protein Array;protein expression;Proteins;Publishing;Recommendation;repository;Research;research clinical testing;Research Personnel;Research Project Grants;Resistance;Resources;response;RNA;Sampling;Specimen;Subgroup;success;synergism;targeted sequencing;targeted treatment;technology development;Therapeutic;Therapeutic Studies;transcriptome sequencing;Translating;treatment response;tumor;University of Texas M D Anderson Cancer Center;Uveal Melanoma;Work

PROJECT_TITLE: Rational Approaches to Melanoma Therapy


NIH_SPENDING_CATS: Cancer;Skin Cancer

PI_NAMEs: VILLANUEVA, JESSIE  (contact)

PROJECT_TERMS: Administrative Efficiency;Cancer Center;Communication;Data Commons;design;Development;Ensure;Environment;Fostering;Institution;Leadership;meetings;Melanoma;member;Occupational activity of managing finances;patient derived xenograft model;Pennsylvania;Pilot Projects;Policies;Process;programs;Regulation;Research;Research Personnel;Services;Structure;The Wistar Institute;Translational Research;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Skin Cancer

PI_NAMEs: HERLYN, MEENHARD F (contact)

PROJECT_TERMS: 3-Dimensional;Biological;Biological Assay;Biological Models;Cell Aggregation;cell bank;Cell Line;Cells;Cellular biology;Clinical;Collaborations;Collagen;Data;data sharing;Data Storage and Retrieval;Databases;Development;Dimensions;Disease;DNA;DNA sequencing;Ensure;exome;experimental study;Freezing;Future;Genetic;Genetic Fingerprintings;Growth;Guidelines;Human;Immunodeficient Mouse;In Vitro;in vitro Model;in vivo Model;investigator training;Laboratories;Lesion;Melanoma;Melanoma Cell;member;Methodology;Methods;Modeling;Molecular;Molecular Abnormality;Molecular Profiling;Monitor;Mus;Neoplasm Metastasis;neoplastic cell;novel therapeutics;Organoids;pathogen;patient derived xenograft model;Patients;Pilot Projects;pre-clinical;Pre-Clinical Model;preclinical study;programs;protein expression;Quality Control;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Scientist;screening;Services;Skin;Specimen;spheroids;subcutaneous;success;Testing;three-dimensional modeling;tool;Training;transcriptome sequencing;tumor;tumor growth;Work

PROJECT_TITLE: PDX Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Skin Cancer

PI_NAMEs: KOSSENKOV, ANDREW V (contact)

PROJECT_TERMS: Address;Bioinformatics;Characteristics;Consultations;Data;Data Analyses;data management;Data Security;Development;Ensure;Environment;Experimental Designs;experimental study;Generations;Goals;Manuscripts;Melanoma;member;Molecular;mRNA Expression;Mutation;Pharmacotherapy;preclinical study;Preclinical Testing;Preparation;Process;programs;Progress Reports;protein expression;Protocols documentation;Quality Control;Research;Research Design;Research Personnel;Research Project Grants;Research Proposals;Sample Size;Statistical Data Interpretation;treatment response;Writing

PROJECT_TITLE: Bioinformatics Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prostate Cancer;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE: Male stress urinary incontinence (SUI), a frequent result of radical prostatectomy for prostate cancer, significantly reduces health-related quality of life among older men. Surgical treatment options are known to provide near-term improvement in quality of life with high satisfaction rates but are underutilized and patients have regret about treatment decisions. The goal of this K76 proposal is to improve goal-concordant treatment decisions for SUI management in older men by identifying disparities in surgical care and addressing these disparities by developing a geriatric-informed patient-centric decision support tool to promote individualized, goal-concordant decision-making for SUI treatment decisions among older men, which will then be tested in an R01 multi-institutional implementation-effectiveness trial.

PI_NAMEs: HAMPSON, LINDSAY ANN (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Academic Medical Centers;Address;Adoption;Affect;Age Years;Aging;Award;career;career development;Caring;Characteristics;clinical practice;cohort;Cohort Studies;Complex;cost;Data;Decision Making;Dedications;design;Diagnosis;Disease;Disparity;effectiveness/implementation study;effectiveness/implementation trial;Elderly;Equity;Ethics;Evaluation;experience;Experimental Designs;experimental study;Face;feasibility trial;Foundations;functional decline;Funding;Future;Geographic Locations;Geriatrics;Goals;Guidelines;Health;health care disparity;health related quality of life;Health Services Accessibility;Health Services Research;Health system;Healthcare Systems;implementation outcomes;implementation science;improved;Incontinence;individual patient;individualized medicine;innovation;Institution;International;Intervention;Interview;K-Series Research Career Programs;Knowledge;Leadership;Link;male;Malignant neoplasm of prostate;Measures;Medicare;men;Mental Depression;Mentors;Mentorship;Methods;multidisciplinary;older adult;older men;Older Population;Operative Surgical Procedures;patient oriented;patient population;Patient Preferences;Patients;personalized decision;pilot test;preference;Prostate Cancer therapy;Prostatectomy;Protocols documentation;prototype;Quality of life;Race;Radical Prostatectomy;recruit;Regrets;Reporting;Research;Research Personnel;Risk;Rural;satisfaction;Shame;Site;Social isolation;Socioeconomic Factors;Stress Urinary Incontinence;Structure;support tools;Surveys;Testing;theories;Time;Training;treatment disparity;United States Department of Veterans Affairs;urinary;Urinary Incontinence;urologic;Urologist;Urology;usability;young man

PROJECT_TITLE: Improving Patient-Centered Decision-Making for Stress Urinary Incontinence Treatment in Older Men


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Precision Medicine;Skin Cancer

PROJECT_TERMS: acquired drug resistance;Address;anti-PD-1;bench to bedside;beta catenin;Biological;biomarker identification;BRAF gene;BRD2 gene;Bromodomains and extra-terminal domain inhibitor;cancer therapy;Cancer Therapy Evaluation Program;Cell Cycle;Cells;Chemoresistance;Child;Clinical;clinical development;clinical predictors;clinical subtypes;clinical translation;Collection;Combined Modality Therapy;Complex;Critical Pathways;Data;design;Development;digital;Disease;Dose;Drug Combinations;Drug resistance;drug testing;Drug Tolerance;exome sequencing;Failure;Gene Expression Profile;Genetic Transcription;genomic profiling;Genomics;Goals;Growth;Heterogeneity;Immunotherapy;improved;improved outcome;individualized medicine;inhibitor;KDM5B gene;Malignant Neoplasms;MAP Kinase Gene;MEKs;Melanoma;Melanoma patient;Metabolic;Metastatic Melanoma;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Molecular;Molecular Profiling;Monitor;mutant;Mutation;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Organoids;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;PD-1 inhibitors;Peroxisome Proliferator-Activated Receptors;personalized approach;Pharmaceutical Preparations;Phosphotransferases;posters;pre-clinical;Precision therapeutics;preclinical study;prevent;Property;Proteins;Proteomics;Recurrent tumor;Refractory;Relapse;research clinical testing;Research Project Grants;Resistance;response;response biomarker;Safety;Signal Transduction;Somatic Mutation;targeted agent;targeted treatment;Testing;Therapeutic;therapy design;Toxic effect;transcriptome sequencing;transcriptomics;Translating;treatment optimization;Treatment outcome;Treatment Protocols;treatment response;tumor;tumor heterogeneity;Validation;Work

PROJECT_TITLE: Functional precision approaches to overcome intrinsic and acquired drug resistance in melanoma


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: WORCESTER

ORG_NAME: MICROBIOTIX, INC

PHR: Project Narrative Filoviruses, including Ebola virus and Marburg virus, are highly pathogenic viruses that cause hemorrhagic fever in humans with a case fatality rate up to 90%, with an unmet medical need for new agents to combat filovirus infections. This proposal is designed to develop a novel series of antibody drug conjugates (ADCs) that combine an efficacious pan-filovirus small molecule inhibitor with an efficacious bispecific pan-filovirus antibody (bNAb) to target entry of filoviruses with the potential for synergistic activity, broadening the therapeutic window and easing drug stockpiling efforts. The broad range of bNAbs, mAbs and small molecules available for conjugation provides a high probability of identifying a succeeding in identifying ADCs appropriate for preclinical development en route to effective pan-filovirus therapeutics.

PI_NAMEs: LIU, GAI  (contact)

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: acute toxicity;Address;Africa;Animal Model;Anti-viral Agents;Antibodies;Antibody-drug conjugates;Binding;Binding Sites;Biological;Biological Assay;bioweapon;Bispecific Antibodies;Carrier Proteins;Case Fatality Rates;Categories;Cathepsins B;Centers for Disease Control and Prevention (U.S.);Cholesterol;Classification;clinical candidate;Clinical Trials;combat;Cytosol;cytotoxicity;Death Rate;Democratic Republic of the Congo;design;Development;Disease Outbreaks;Dose;Drug Design;drug development;Drug Kinetics;Ebola virus;emerging virus;Endosomes;Epidemic;Epitopes;Evaluation;Exhibits;Exposure to;Family;FDA approved;Filoviridae Infections;Filovirus;Future;Glycoproteins;Goals;Hepatitis C;Hepatitis C virus;Hospitalization;Human;improved;In Vitro;in vivo;Infection;Influenza;inhibitor;late endosome;Lead;Life Cycle Stages;Link;Literature;Lysosomes;Marburgvirus;Medical;member;Membrane Fusion;Modeling;Monoclonal Antibodies;mouse model;Mus;Nature;neutralizing antibody;neutralizing monoclonal antibodies;New Agents;nonhuman primate;novel;pathogenic virus;Patients;Periodicals;Pharmaceutical Preparations;Phase;phenylpiperazine;preclinical development;Prevention;Probability;Property;prophylactic;Proteins;receptor;receptor binding;Reporting;Research;RNA Interference;Route;Safety;Series;Serum;Small Business Innovation Research Grant;small molecule;small molecule inhibitor;Sudan Ebola virus;Surface;synergism;targeted delivery;Therapeutic;Therapeutic antibodies;Toxic effect;Vaccines;Vesicular stomatitis Indiana virus;Viral;viral entry inhibitor;Viral Hemorrhagic Fevers;Viral Physiology;Viral Proteins;Virion;Virulent;Virus;virus classification;Virus Diseases;Work;Zaire Ebola virus

PROJECT_TITLE: Development of antibody drug conjugates as pan-filo antivirals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Services;Hearing Loss;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Rehabilitation

ORG_CITY: NEW YORK

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative This proposal is significant to public health in that age-related hearing loss is common and if untreated, negatively impacts on healthy aging and quality of life. This study tests the feasibility of a hearing screening and counseling program on patient-centered rehabilitation strategies for older adults in a public hospital primary care clinic.

PI_NAMEs: FRIEDMANN, DAVID R (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Adult;Age Years;Aging;Agreement;American;Audiology;Award;biopsychosocial;care delivery;career;career development;Caring;Cellular Phone;Chronic;Clinic;Collection;Communication;Communication difficulty;Computer Assisted;cost;Counseling;Data;design;Devices;Disabling;Ear;efficacy trial;Eligibility Determination;Ensure;Equity;Evaluation;feasibility testing;Feedback;follow-up;Future;Goals;Health;health care disparity;health care service utilization;healthy aging;Hearing;Hearing Aids;hearing impairment;hearing screening;Impaired cognition;implementation science;improved;inattention;innovation;insight;Intervention;Learning;Logistics;Measures;Medical;Methods;Modeling;novel;older adult;Older Population;Outcome;Participant;Pathway interactions;patient oriented;patient screening;Patients;Population;Preparation;Presbycusis;Primary Care;primary care clinic;primary care practice;primary care setting;primary care visit;Process;programs;Provider;Public Health;Public Hospitals;Quality of Care;Quality of life;Randomized;Recommendation;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Research Personnel;screening;screening program;Self Administration;self testing;shared decision making;Site;Social isolation;Specialist;Surveys;Training;United States Preventative Services Task Force;Work

PROJECT_TITLE: Feasibility of a Hearing Program in Primary Care for Underserved Older Adults


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunotherapy;Orphan Drug;Precision Medicine;Rare Diseases;Skin Cancer

PI_NAMEs: DAVIES, MICHAEL  (contact)

PROJECT_TERMS: Acral Lentiginous Malignant Melanoma;Address;Aftercare;Apoptosis;Apoptotic;Automobile Driving;BCL2 gene;biological adaptation to stress;biomarker driven;biomarker identification;BRAF gene;Cancer Therapy Evaluation Program;Cells;Cessation of life;Clinical;Clinical Research;Clinical Trials;clinically relevant;Collection;Combined Modality Therapy;Cutaneous Melanoma;Data;design;DNA Damage;DNA Repair;Dose Limiting;Drug resistance;early phase clinical trial;effective therapy;efficacy evaluation;Exhibits;Future;Gene Mutation;gene repair;Genes;Genotoxic Stress;Goals;High Prevalence;Immune checkpoint inhibitor;Immunotherapy;In Vitro;in vivo;Induction of Apoptosis;inhibitor;Lead;Malignant Neoplasms;MAP Kinase Gene;MCL1 gene;Mediating;MEKs;Melanoma;Melanoma patient;Metastatic Melanoma;Mitogen-Activated Protein Kinase Inhibitor;Molecular;Molecular Analysis;mutant;Mutation;neoplastic cell;Non-Cutaneous Melanoma;novel;novel strategies;overexpression;Pathway interactions;Patients;personalized medicine;personalized therapeutic;prevent;Proteins;Refractory;Research Personnel;Resistance;Resistance development;Resources;responders and non-responders;response;response biomarker;Skin Cancer;Somatic Mutation;targeted agent;targeted sequencing;targeted treatment;Testing;Therapeutic;therapeutically effective;therapy resistant;Toxic effect;Translating;Treatment Efficacy;Treatment outcome;treatment strategy;tumor;tumor growth;Tumor Promotion;years of life lost

PROJECT_TITLE: Personalized targeting of anti-apoptosis pathways to overcome therapeutic resistance in melanoma


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE It is increasingly becoming apparent that reproductive fitness has a major impact on the overall health and aging of the individual but little is known about the mechanisms underlying. This project utilizes the model nematode, C. elegans, to identify genes that determine how meiosis in germ cells influences overall aging. The research has relevance for human health and high public-health significance because human counterparts of genes being studied here have been implicated in human reproductive aging, so the findings from this work may help design therapies for age-related diseases, especially those pertaining to reproductive health.

PI_NAMEs: GHAZI, ARJUMAND  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Acceleration;Address;advanced maternal age;Age;age-related disease;aged;Aging;aging mechanism;Animals;beta catenin;Biological Assay;Brothers;Caenorhabditis elegans;Cardiovascular Diseases;Clinical;Coal;comorbidity;Data;Defect;Dementia;Epidemiology;epigenetic aging;Etiology;Exhibits;extend lifespan;Fertility;fitness;Foundations;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genes;genetic approach;Genetic Transcription;Genome;Germ Cells;Germ Lines;Gonadal structure;Health;healthspan;Homologous Gene;Human;human tissue;Impairment;in vivo;Individual;insight;Knowledge;late life;Lead;life span;Ligands;Link;Longevity;Mediating;Meiosis;member;men;Menopause;Modeling;Molecular;Molecular Genetics;mortality;mortality risk;mutant;Mutation;Nematoda;neuronal cell body;novel;Nuclear;Nuclear Accidents;Organism;Outcome;Pathway interactions;Predisposition;Pregnancy;premature;Premature aging syndrome;Process;programs;proteostasis;Public Health;rate of aging;receptor;Regulatory Pathway;Reproduction;reproductive;reproductive fitness;Reproductive Health;reproductive longevity;reproductive senescence;Reproductive system;Research;response;Role;Serinus;sex;Signal Pathway;Signal Transduction;SPO11 gene;Sterility;Testing;Testosterone;therapy design;Tissues;transcription factor;transcriptome;transcriptome sequencing;transmission process;trend;WNT Signaling Pathway;Woman;Women's mortality;Work;young adult

PROJECT_TITLE: Modulation of Lifespan and Healthspan by Meiosis Genes

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_DEPT: PHARMACOLOGY

PHR: NARRATIVE Epilepsy affects over 65 million people worldwide, yet roughly 30% of patients remain resistant to available antiseizure drugs. Newer, better tolerated, and more effective treatments are desperately needed, including agents that can prevent the development of epilepsy in at-risk individuals. This proposal will thus fully characterize the anticonvulsant and potentially disease-modifying potential of two promising candidate investigational treatments for epilepsy.

PI_NAMEs: BARKER-HALISKI, MELISSA LEIGH (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: acquired epilepsy;Acute;Address;Adult;Affect;Animal Model;Animals;Anticonvulsants;Antiepileptogenic;Behavior assessment;behavioral impairment;beta catenin;Biological Assay;Bone Growth;Brain;Caring;Chemicals;Chronic;Clinical;clinically relevant;cohort;Cornea;Data;Development;Disease;Dose;drug market;drug repurposing;Drug resistance;drug standard;effective therapy;Electroconvulsive Shock;Electroencephalography;Epilepsy;FDA approved;Female;Focal Seizure;Goals;habituation;Harvest;Homeostasis;indexing;Individual;Intractable Epilepsy;intraperitoneal;Investigational Therapies;Levetiracetam;Life;Locomotion;male;Marketing;Medical;Methodology;Modeling;Molecular Target;motor impairment;mouse model;Mus;nervous system development;Neurologic;Neurons;novel;Oral Administration;Organ;Outcome;Pathway interactions;Patients;Pentylenetetrazole;Peripheral;Persons;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;Plasma;pre-clinical;prevent;preventable epilepsy;Prevention;Published Comment;Rattus;Recurrence;Resistance;Risk;Rodent;Rodent Model;Route;screening;Seizures;Severities;Signal Transduction;small molecule;standard of care;Status Epilepticus;subcutaneous;symptom treatment;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;Toxic effect;Toxicology;tumor;Valproic Acid;WNT Signaling Pathway;Work

PROJECT_TITLE: Investigational WNT-pathway modulators for the treatment and prevention of drug-resistant seizures

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARATIVE Humans are colonized with a large number of microorganisms, collectively known as the microbiota that provide us with key functions. Signals from these microbes regulate immunological functions and play a key role in inflammatory disease. We will investigate how mucosal associated microbes drive pro- and anti-inflammatory immune responses to define their role in intestinal homeostasis.

PI_NAMEs: DIEHL, GRETCHEN E (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;Animal Disease Models;Anti-Inflammatory Agents;antimicrobial;Calibration;CD4 Positive T Lymphocytes;Cell Communication;Cell Death;Cell Physiology;cell type;Cells;Characteristics;Chronic;commensal microbes;Communicable Diseases;Communities;cytokine;Dendritic Cells;Development;Disease;dysbiosis;enteric infection;Escherichia coli;Event;Generations;Goals;gut inflammation;gut microbes;gut microbiota;Homeostasis;Human;Immune;immune activation;immune function;Immune response;Immune system;immune system function;Immunity;improved;improved outcome;In Vitro;in vivo Model;Individual;Inflammasome;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;intestinal barrier;intestinal epithelium;intestinal homeostasis;intestinal injury;Intestines;Left;Macrophage;Maintenance;Microbe;microbial;microbiota;microorganism;Molecular;mucosal microbiota;Mucous Membrane;Mus;normal microbiota;novel;pathogen;Pathogenicity;Pathologic;Pathology;Pathway interactions;Penetration;Physiological;Play;Population;Predisposition;Production;protective effect;Regulation;Regulatory Pathway;repaired;response;restraint;Role;Shapes;Signal Transduction;Site;T cell response;T-Lymphocyte;Testing;Tissues;Work

PROJECT_TITLE: Orchestrating intestinal immunity through microbiota-CX3CR1+ cell interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMII-U(01)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Skin Cancer

PROJECT_TITLE: Pilot-Trans Network Core


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Sleep Research

PHR: NARRATIVE The proposed work will support Dr. Martin's mentorship of early-career clinical researchers in patient oriented research related ot sleep health in special populations. The protected time and additional resources provided by this award will allow her to expand her successful research mentoring program in patient oriented research and continue to dedicate time to additional leadership development and training. The program will benefit from Dr. Martin's ongoing program of patient-oriented research focused on treatment of sleep disorders, and from the resource-rich environment at UCLA and VAGLAHS.

PI_NAMEs: MARTIN, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Address;Adherence;Aftercare;Anxiety;Area;Attenuated;avoidance behavior;Award;Behavior;Behavioral;career;Clinical;clinical center;Clinical Trials;Cognitive;Cognitive Therapy;Combined Modality Therapy;Comorbid Insomnia;comorbidity;comparative effectiveness;Data Analyses;data dissemination;Dedications;design;Development;diaries;Disadvantaged;Discipline;Education;Educational Curriculum;effectiveness evaluation;Environment;Epidemiology;evidence base;Evidence based intervention;Exercise;experience;Feeling suicidal;flexibility;follow-up;Funding;Geriatrics;Goals;Health;health disparity;Hospitalization;implementation evaluation;implementation research;implementation science;improved;improvement on sleep;Individual;innovation;Institutionalization;interest;Intervention;Leadership;leadership development;Learning;Los Angeles;medical specialties;Mental Depression;Mental Health;Mentors;Mentorship;Methodology;Methods;mindfulness;National Heart, Lung, and Blood Institute;Neurobehavioral Manifestations;novel;Nurses;older adult;Outcome;Outcome Measure;Participant;patient oriented;patient oriented research;patient population;Patient-Focused Outcomes;Patients;Physicians;Population;Population Heterogeneity;Populations at Risk;positive airway pressure;Post-Traumatic Stress Disorders;Process Measure;programs;psychiatric comorbidity;psychologic;Psychologist;Quality of life;Randomized;randomized trial;reducing suicide;Relaxation;Research;Research Personnel;Resources;Respiration Disorders;Risk;Scientist;Severities;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;Sleep Disorders Therapy;sleep health;sleep quality;sleep-focused interventions;Sleeplessness;Special Population;Spinal cord injury patients;Stimulus;Symptoms;Techniques;Testing;theories;Time;Training;treatment response;United States National Institutes of Health;Veterans;Woman;Work

PROJECT_TITLE: Sleep health in special populations

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Organ Transplantation;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The Latinx community (gender-inclusive term; includes Hispanics, Latino/a) bears a disproportionate burden of chronic kidney disease (CKD) and are less likely to start recommended kidney replacement therapy, such as kidney transplant or home dialysis, compared to non-Latinx Whites. NAVIGATE-Kidney is a multi-level, community-engaged, language and culturally concordant community health worker intervention for Latinx with advanced CKD, that will reduce kidney health disparities, and address structural racism. Results from this study will provide important research evidence for solutions to reduce kidney health disparities and inform local, state, and federal health policy changes.

PI_NAMEs: CERVANTES, LILIA  (contact);MYASKOVSKY, LARISSA

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Address;American;American Indian community;American Indians;Arteriovenous fistula;arteriovenous graft;Blood Vessels;Caring;Catheters;Chronic Kidney Failure;Colorado;Communities;community engaged research;Community Health Aides;community partners;Complex;Conflict (Psychology);contextual factors;cost;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness evaluation;Data;Dialysis procedure;Discrimination;Disparity;distrust;economic evaluation;Education;Effectiveness;effectiveness evaluation;effectiveness outcome;Ensure;Equity;ethnic minority;Ethnic Population;Evaluation;experience;Face;Family;food environment;Funding;Gender;Geography;Goals;Health;Health Care Sector;health disparity;health equity;Health Insurance;health literacy;Health Policy;Hemodialysis;high risk;Hispanic Populations;Home;Hospitalization;implementation context;implementation framework;implementation outcomes;Improve Access;improved;Incentives;Individual;Infection;innovation;Intervention;intervention participants;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Language;Latino;Latinx;Latinx population;Measures;member;Methods;Modeling;mortality;mortality risk;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute on Minority Health and Health Disparities;New Mexico;Organizational Policy;Participant;Patient-Centered Care;Patient-Focused Outcomes;Patients;payment;Peritoneal Dialysis;person centered;Phenotype;Policies;Policy Maker;Poverty;Practical Robust Implementation and Sustainability Model;primary outcome;Procedures;Provider;racial minority;racial population;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Renal Replacement Therapy;Research;response;Schedule;secondary outcome;shared decision making;social health determinants;standard care;Structural Racism;Structure;Testing;Transplant Recipients;Transplantation;trial comparing;United States Centers for Medicare and Medicaid Services;Venous;Visit;Waiting Lists;Work

PROJECT_TITLE: NAVIGATE Kidney: A Multi-Level Intervention to Reduce Kidney Health Disparities


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Data Science;Dementia;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Patient Safety;Precision Medicine;Prevention

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Narrative We will build an end-to-end system to convert electronic health records (EHR) to Fast Healthcare Interoperability Resources (FHIR) with integrated machine learning models to explore multiple chronic diseases (MCC)’s impact on Alzheimer's disease. Partnering with ACTIVE MIND, an interventional trial that examines the potential efficacy of cognitive training (CT) in reducing dementia incidences, we will develop a demonstration project to promote the use of interoperable health records in clinical research by identifying and stratifying patients with Mild Cognitive Impairment (MCI) who are at risk for developing Alzheimer's disease.

PI_NAMEs: BIAN, JIANG ;JIANG, XIAOQIAN  (contact);TAO, CUI

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: African American population;aging population;Alzheimer's Disease;Alzheimer's Disease Pathway;Alzheimer's disease risk;application programming interface;Biological Markers;burden of illness;Cardiovascular Diseases;care costs;care seeking;Caucasians;cerebral atrophy;Characteristics;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Data;Clinical Pathways;Clinical Research;cognitive benefits;cognitive testing;cognitive training;cohort;comorbidity;Complex;Consent;Data;Data Coordinating Center;data format;data imputation;data standards;Databases;deep learning;Dementia;Development;Diagnosis;Disease Progression;efficacy evaluation;Electronic Health Record;electronic health record system;Eligibility Determination;Ethnic Population;Fast Healthcare Interoperability Resources;Florida;Health;health record;Health system;Healthcare;Impaired cognition;Incidence;Informatics;insight;interest;interoperability;Intervention Trial;Knowledge;Link;machine learning model;Maps;Medical;Mental Depression;Methods;mild cognitive impairment;Modeling;multiple chronic conditions;Natural Language Processing;Nature;novel;Obstructive Sleep Apnea;Onset of illness;Ontology;Outcome;outcome prediction;Participant;patient stratification;patient subsets;Patients;Pattern;Performance;Periodontitis;pharmacologic;Phenotype;phenotyping algorithm;Prevalence;Process;Public Health;racial population;Records;recruit;Research;Research Personnel;response;Risk;Risk Factors;screening;Standardization;Structure;structured data;success;System;Testing;tool;unstructured data;Work;World Health

PROJECT_TITLE: An end-to-end informatics framework to study Multiple Chronic Conditions (MCC)'s impact on Alzheimer's disease using harmonized electronic health records


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Structural racism is an important contributor to disparities in kidney disease. The proposed research coordinating center will support a research network and multiple clinical trials focused on addressing structural racism to reduce disparities in kidney health and disease.

PI_NAMEs: BARNHART, HUIMAN X;BENTLEY-EDWARDS, KEISHA L.;WYATT, CHRISTINA M (contact)

PROJECT_TERMS: Address;Ancillary Study;Authorship;Biometry;career;career development;Caring;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Collaborations;Common Data Element;Communication;Communities;community engaged intervention;community engagement;community partners;conflict resolution;cooking;COVID-19 disparity;Data;Data Analyses;Data Collection;data management;data sharing;design;Dialysis procedure;Disease;Disparity;disparity reduction;Educational workshop;Enrollment;Ensure;Equity;experience;Fostering;Funding;Goals;Health;Health Disparities Research;health disparity;Health equity research;Historically Black Colleges and Universities;improved;Infrastructure;Institution;Interdisciplinary Study;Intervention;Intervention Studies;Intervention Trial;Kidney;Kidney Diseases;Leadership;marginalized population;medical schools;meetings;Minority Groups;Monitor;multidisciplinary;North Carolina;Online Systems;operation;Policies;Population Heterogeneity;pragmatic randomized trial;programs;RADx Underserved Populations;recruit;Research;Research Activity;Research Institute;Research Personnel;Resources;Secure;Site;social;Special Population;Statistical Data Interpretation;Structural Racism;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Interventions that Address Structural Racism to Reduce Kidney Health Disparities Research Coordinating Center


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: RICHMOND

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Experiences of loneliness are prevalent among older adults living in the community. The proposed study aims to develop, deploy, and validate a smart speaker-based in-home loneliness assessment system for community-dwelling older adults. This study is highly relevant to public health as it explores the innovative use of commercially available digital technologies to enable a remote loneliness assessment for older adults, which will move assessment out of the clinic and into older adults’ everyday lives to identify lonely individuals early enough to intervene before negative health outcomes occur.

PI_NAMEs: CHUNG, JANE  (contact);NADEEM, TAMER

PROGRAM_OFFICER_NAME: PLUDE, DANA JEFFREY

PROJECT_TERMS: Acoustics;Activities of Daily Living;Adoption;Algorithms;Awareness;Behavioral;Classification;Clinic;Communities;community based service;community partnership;Computers;cultural values;Data;Data Reporting;dementia risk;Detection;Devices;digital;Digital biomarker;digital technology;Dimensions;Effectiveness;Enrollment;experience;Frequencies;functional decline;Future;generative adversarial network;Goals;Grain;Health;Health Personnel;Healthcare Systems;Home;human old age (65+);Impaired cognition;implementation barriers;improved;Individual;innovation;insight;instrument;Internet of Things;Intervention;Label;Life Expectancy;Linguistics;Loneliness;lonely individuals;machine learning algorithm;machine learning model;Measures;Mental Health;modifiable risk;Monitor;Morbidity - disease rate;mortality;Music;Names;novel;older adult;Outcome;Pain;Participant;Patient Self-Report;Patients;Pattern;Performance;physical conditioning;Population;prevent;Primary Care;Privacy;Public Health;recruit;Reporting;Research;Resolution;Risk;Risk Factors;Security;sedentary lifestyle;Sleep;smart speaker;social influence;Social Interaction;social relationships;social stigma;Social Well-Being;Speech;Stream;System;Telephone;Testing;therapy design;Time;Training;virtual;Work

PROJECT_TITLE: HomePal: Developing a Smart Speaker-Based System for In-Home Loneliness Assessment for Older Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-X(90)S]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Overall PROJECT NARRATIVE The Center for Somatic Cell Genome Editing in Nonhuman Primates will serve the research community by supporting innovative studies in nonhuman primates to identify safe and efficient treatments for human diseases. The program will ensure essential resources, expertise, and research opportunities are available for investigators nationwide to advance new and emerging genome editing therapies for patients in need across all age groups, and in a collaborative multidisciplinary setting that promotes transparency and data sharing.

PI_NAMEs: HARTIGAN-O'CONNOR, DENNIS J.;SEGAL, DAVID J;TARANTAL, ALICE F (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acceleration;Address;Adult;age group;Animal Model;Animal Testing;Animals;Benchmarking;Biological;Biological Assay;Biological Models;California;Center for Translational Science Activities;Clinical Sciences;Clinical Trials;Collaborations;Communication;Communities;data exchange;data sharing;Development;disease model;Emerging Technologies;empowerment;Ensure;Evaluation;experience;Feedback;fetal;Fostering;Future;gene therapy;Genome;genome editing;Goals;Governing Board;home test;Human;human disease;immunogenicity;Inflammation;Infrastructure;innovation;Leadership;Letters;life span;meetings;Methodology;Modeling;multidisciplinary;new technology;nonhuman primate;Office of Administrative Management;organizational structure;outreach;Patients;Positioning Attribute;pre-clinical research;Preclinical Testing;prenatal;Primates;Procedures;Process;Productivity;programs;Reagent;Reporter;Research;Research Personnel;Research Priority;Resources;Role;Safety;Schedule;Scientist;Services;somatic cell gene editing;Specificity;synergism;System;Techniques;Technology;Testing;Therapeutic;therapeutic genome editing;tool;Translational Research;Translations;United States National Institutes of Health;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-V(50)R]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

PI_NAMEs: TARANTAL, ALICE F (contact)

PROJECT_TERMS: Achievement;Address;Adult;Applications Grants;Benchmarking;Biological;California;Cells;Center for Translational Science Activities;Clinical Sciences;cohesion;Collaborations;Communication;Communities;cost effectiveness;Data;data sharing;disease model;Ensure;Equity;Evaluation;Fee-for-Service Plans;fetal;Future;Genome;genome editing;Goals;Grant;Growth;Home;home test;Information Dissemination;Infrastructure;interest;Investigation;Knowledge;Leadership;life span;meetings;Methods;Modeling;multidisciplinary;nonhuman primate;novel therapeutics;Office of Administrative Management;outreach;Policies;pre-clinical;Preparation;Primates;Procedures;Process;Productivity;programs;Progress Reports;Protocols documentation;Publications;Rare Diseases;Reporter;Reporting;repository;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;Safety;Services;somatic cell gene editing;Strategic Planning;Structure;Technology;Test Result;Testing;Tissues;tool;Translational Research;United States National Institutes of Health;user-friendly

PROJECT_TITLE: Coordination Component

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-V]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative As the burden of Alzheimer’s disease and related dementias in the United States and worldwide is high, there is a critical and unmet clinical need to develop and translate novel positron emission tomography (PET) imaging tools to study neurodegeneration-related biological processes in the brain. This work will validate and translate key imaging ligands in humans designed to substantially advance our scientific understanding of subtype-specific N-methyl-D-aspartate receptor and its role in the pathophysiology and glutamatergic signaling transduction pathway of Alzheimer’s disease (AD), facilitating drug discovery of novel neurotherapeutics for AD patients.

PI_NAMEs: LAH, JAMES J;LIANG, STEVEN H (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: 3xTg-AD mouse;AD transgenic mice;Affinity;Age;Alzheimer's Disease;Alzheimer's Disease Pathway;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Amyloid beta-Protein;Animals;Autopsy;Autoradiography;Binding;Biological;Biological Process;Blood;Blood specimen;Brain;Brain region;brain tissue;Characteristics;Clinical;Clinical Trials;Cognition;Cognitive deficits;cohort;Correlation Studies;Data;Dementia;design;Development;disease model;Disease Progression;drug development;drug discovery;efficacious treatment;Evaluation;excitotoxicity;Functional disorder;Future;glutamatergic signaling;Glutamates;Goals;healthy volunteer;Homeostasis;Human;Image;imaging biomarker;Imaging Device;Imaging ligands;imaging study;In Vitro;in vivo;in vivo imaging;indexing;Individual;kinetic model;Kinetics;Knowledge;Learning;Longitudinal Studies;Maps;Measures;Mediating;Medical;Memory;Metabolism;Methods;molecular imaging;Monitor;mouse model;N-Methyl-D-Aspartate Receptors;Nerve Degeneration;Neuroimmune;neuroinflammation;neurotoxicity;novel;old mice;Outcome Measure;Patient Selection;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Pilot Projects;Plasma;Play;Positron-Emission Tomography;pre-clinical;Radiopharmaceuticals;radiotracer;Receptor Activation;receptor function;Reporting;Role;Signal Transduction;Signal Transduction Pathway;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;targeted imaging;tau expression;tau-1;Testing;Therapeutic Intervention;Tissues;tool;Tracer;Translating;Translations;Treatment Efficacy;United States;Work

PROJECT_TITLE: Translation of GluN2B-selective PET radiopharmaceuticals in Alzheimers patients

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


PI_NAMEs: SEGAL, DAVID J (contact)

PROJECT_TERMS: Acceleration;adaptive immunity;Address;Adult;age group;Animals;Antibodies;B-Lymphocytes;base editor;Biodistribution;Biological;Biological Assay;Biological Markers;Biopsy;Body System;bone;Brain;California;Cell Physiology;cell type;Cells;Center for Translational Science Activities;Clinical Chemistry;Clinical Sciences;Collaborations;Communities;comparative;Data;Data Collection;delivery vehicle;design;Disease;disease model;disease phenotype;DNA;Ear;Ensure;Equity;Evaluation;Event;Eye;Female;fetal;flexibility;Frequencies;Genes;Genome;genome editing;genome editor;Genomic DNA;Goals;Gonadal structure;Heart;Hematology;Hematopoietic System;Histologic;Homeostasis;human disease;Immune response;immunogenicity;In Vitro;in vivo;in vivo imaging;Inflammation;Infrastructure;insertion/deletion mutation;Kidney;Link;Lipids;Liver;Lung;male;Measurement;Metabolic;Methods;Modeling;Muscle;Mutation;Natural Immunity;Non-Viral Vector;nonhuman primate;off-target site;optical imaging;organizational structure;Population Group;Positron-Emission Tomography;Primates;Procedures;Process;programs;Proteins;quality assurance;Quality Control;Reagent;Reporter;Reproducibility;Research;Research Design;Research Personnel;Resolution;Resources;Safety;Sex Differences;shared database;single-cell RNA sequencing;Site;Somatic Cell;somatic cell gene editing;Specificity;Standardization;System;T cell response;T-Lymphocyte;Techniques;Technology;Testing;Tissues;tool;Translations;Viral Vector;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Genome Editing and Biological Effects Testing Component


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: SURGERY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE. Extracellular vesicles and particles (EVPs) have emerged as important mediators β cell-immune cell interaction and β cell dysfunction and survival in type 1 diabetes (T1D). Here, we have assembled an interdisciplinary team to systematically examine the role of human islet/pancreas-associated EVPs in islet cell function and survival during T1D progression. This study will identify novel “biomarkers” for T1D diagnosis and pave the road to the development of new therapy strategies to treat and prevent the progression of T1D.

PI_NAMEs: CHEN, SHUIBING  (contact);LYDEN, DAVID CHARLES;RAFII, SHAHIN

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Alpha Cell;Antigen Presentation;Antigen-Presenting Cells;Apoptotic;autoreactivity;Beta Cell;Binding;Biological Markers;Biology;Blood Vessels;Body Fluids;Cell Communication;Cell Line;Cell membrane;Cell Physiology;Cell Survival;cell type;Cells;Coxsackie Viruses;cytokine;Databases;Development;diabetes pathogenesis;Diagnosis;DNA;Endocrine;Endothelial Cells;exosome;extracellular;extracellular vesicles;Field Flow Fractionation;Functional disorder;gain of function;Heterogeneity;Human;human pluripotent stem cell;Immune;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;islet;Islet Cell;Lipid Bilayers;Lipids;Macrophage;Mediating;Mediator;Membrane;Membrane Proteins;Methods;Microfluidic Microchips;MicroRNAs;MLLT2 gene;Molecular;Molecular Profiling;mouse model;nanoparticle;novel marker;novel therapeutic intervention;novel therapeutics;Organ;Organoids;Outcome;Pancreas;particle;Pathogenicity;Pathologic;Patient Care;Patients;Plasma;prevent;Proteins;Proteomics;RNA;Role;Sampling;senescence;signature molecule;Slice;Stress;Structure;superresolution imaging;Technology;Testing;Tissues;Ultracentrifugation;Vascular blood supply;Vascularization

PROJECT_TITLE: Abnormal Extracellular Vesicles and Particles from Human Islets Impact T1D progression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-L(02)M]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Infertility;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: THERAPYX, INC.

PHR: NARRATIVE-PUBLIC HEALTH RELEVANCE Gonorrhea is the second most frequent reportable bacterial infectious disease in the US with a reported incidence of 696,764 cases in 2021, reflective of a steady increase in recent years. Because of under-reporting and symptomatic treatment, the real incidence is believed to be much greater. Worldwide incidence is now estimated at greater than 87 million new cases per annum. Untreated gonorrhea in women can lead to upper genital tract infection and pelvic inflammatory disease, with tubal scarring, infertility, and risk for ectopic pregnancy. It also increases the risk of acquisition and transmission of HIV up to 5-fold, for reasons that remain unclear. Because no vaccine is available, control and treatment depend upon antibiotics, but N. gonorrhoeae has steadily developed resistance to each class of antibiotics deployed against it, including fluoroquinolones and most recently even cephalosporins. Importantly, gonorrhea can be acquired repeatedly with no development of protective immunity, compounding the danger of emerging antibiotic resistance. This CRP proposal seeks to further the development of an intravaginally administered formulation of the key inflammatory cytokine interleukin-12 (GneX12) as a novel therapeutic vaccine against gonorrhea, to be used in conjunction with standard-of-care antibiotics, and as a failsafe therapeutic treatment against emerging super-resistant strains.

PI_NAMEs: AUCI, DOMINICK  (contact);RUSSELL, MICHAEL W

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Acceleration;acute toxicity;Agreement;analytical method;Antibiotic Therapy;Antibiotics;Antibodies;Antibody Response;Antimicrobial Resistance;Attenuated Vaccines;Award;Biological;Biological Sciences;Biotechnology;Cephalosporins;Cicatrix;Clinical;Clinical Research;Clinical Trials;Collaborations;Communicable Diseases;Communication;comparative;Consultations;cost effective;cross immunity;Cyclic GMP;cytokine;Dedications;design;Development;Dose;Drug Compounding;Drug Kinetics;drug-resistant gonorrhea;Ectopic Pregnancy;emerging antibiotic resistance;Encapsulated;Fluoroquinolones;Formulation;Funding;Future;Goals;Gonorrhea;HIV;Human;Immunity;Immunotherapeutic agent;Immunotherapy;Incidence;Infection;Infertility;Inflammatory;Interleukin-12;Intravaginal Administration;Investigational Drugs;Legal patent;Macaca fascicularis;manufacture;manufacturing process;manufacturing scale-up;Marketing;Mediating;meetings;Methods;Monkeys;mouse model;Mucous Membrane;Multi-Drug Resistance;Mus;Neisseria gonorrhoeae;nonhuman primate;novel;novel therapeutics;particle;Pelvic Inflammatory Disease;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phase I/II Clinical Trial;Phase I/II Trial;Pichia;Preparation;Primates;product development;Production;Prophylactic treatment;Public Health;public health relevance;Qualifying;Rattus;Readiness;Recombinants;Recommendation;Regimen;Reporting;reproductive;reproductive toxicity;reproductive tract;Resistance development;resistant strain;response;Risk;Rodent;Role;scale up;Secure;Small Business Innovation Research Grant;Source;Specific qualifier value;standard of care;symptom treatment;T-Lymphocyte;Testing;Therapeutic;therapeutic vaccine;Toxic effect;Toxicology;transmission process;treatment optimization;Treatment Protocols;Universities;Vaccines;Woman;Work

PROJECT_TITLE: Therapy and Prophylaxis for Genital Tract Infection


PROJECT_TERMS: Acceleration;adaptive immunity;Adenocarcinoma;Adolescent;Adult;Age;age group;aging related;animal care;Animal Housing;Animal Husbandry;Animals;behavioral health;biobank;Biological;Blood Cells;Blood specimen;Breeding;California;Caring;Certification;Cohort Studies;Data;Degenerative polyarthritis;Development;Disease;disease model;Elderly;emergency preparedness;Emergency Situation;Ensure;Evaluation;experience;Eye diseases;Female;fetal;Funding Mechanisms;Future;Genetic;genome editing;genome editor;Goals;hazard;Health;Health Services;Heart Diseases;high volume manufacturing;Human;human disease;immunodeficiency;immunogenicity;in utero;Infrastructure;Investigation;Kidney Diseases;Knowledge;life history;life span;Macaca mulatta;male;Medicine;Methods;Modeling;Newborn Infant;nonhuman primate;novel therapeutics;Pathology;Population;postnatal;Primates;Procedures;Productivity;programs;quality assurance;Quality Control;Quarantine;Reporter;Reproducibility;reproductive;Research;Research Personnel;Research Project Grants;Resources;Safety;safety assessment;Sample Size;Sampling;searchable database;Security Measures;Services;Site;somatic cell gene editing;Specificity;Specimen;System;Technology;Testing;Translations;United States National Institutes of Health

PROJECT_TITLE: Resource Component