NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: DURHAM

PHR: PROJECT NARRATIVE Some of the most important drugs used to treat cardiovascular diseases such as "ARBs" (angiotensin receptor blockers) target specific receptors on the outside of cells. Here we seek to understand, at a molecular level, a novel mechanism by which these receptors signal to the inside of cells, laying the basis for next-generation therapeutics for cardiovascular and other diseases.

PI_NAMEs: LEFKOWITZ, ROBERT J (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Allosteric Regulation;Angiotensin Receptor;ARRB2;arrestin3;attentional bias;base;beta-arrestin;Binding;Biological;biophysical techniques;Cardiovascular Agents;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Cell membrane;Cells;Complex;Congestive Heart Failure;Cryoelectron Microscopy;Data;desensitization;design;Development;Disease;drug development;drug discovery;Drug Receptors;Drug usage;Endocytosis;Enzymes;Event;Family;FDA approved;Funding;G protein coupled receptor kinase;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;Grant;GTP-Binding Proteins;Heterogeneity;Heterotrimeric GTP-Binding Proteins;Hormones;Hypertension;insight;Ligand Binding;Ligands;Link;MAPK1 gene;Mediating;member;Membrane;Modeling;Molecular;Molecular Conformation;Neurotransmitters;novel;novel therapeutics;Pharmaceutical Preparations;Phase;Phosphorylation;Process;programs;Property;Protein Conformation;receptor;Receptor Signaling;Receptor, Angiotensin, Type 1;Regulation;Research;Resolution;Rest;Safety;Sampling;seven-transmembrane G-protein-coupled receptor;side effect;Signal Transduction;Signaling Protein;Site;small molecule;Specificity;Spectrum Analysis;Structure;System;targeted treatment;Therapeutic;Therapeutic Agents;tool;Transducers;Translating;Vision;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular Regulation of Cardiovascular 7 TM Receptors

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infant Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative Poor Black and Hispanic preterm infants often receive care in newborn intensive care units (NICUs) in safety net hospitals. These NICUs tend to have worse performance than those in better resourced hospitals. However, even among safety net NICUs, quality varies widely. We don’t know why some of these safety net NICUs perform well while others are more challenged. In this study, we will address this knowledge gap by bringing a large group of these NICUs together to work together on a common problem area and using this intervention to study what makes these NICUs perform differently from one another. We plan to leverage this joint effort for future collaboration among safety net NICUs.

PI_NAMEs: PROFIT, JOCHEN  (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Abbreviations;Address;Administrator;Area;Automobile Driving;Benchmarking;Black race;burnout;California;care delivery;Caring;Characteristics;Clinical;clinical care;cohort;Collaborations;Communication;dashboard;Data;data resource;Data Set;design;deviant;Dimensions;Disparity;disparity reduction;Epidemiology;Equity;ethnic disparity;Ethnic Origin;Evaluation;Exhibits;feeding;Funding;Future;Graph;health care disparity;health equity;Health Personnel;Healthcare;healthcare-associated infections;Hispanic;Hospitals;Human Milk;implementation framework;improved;Infant;informant;Infrastructure;innovation;Institutional Racism;Intervention;Interview;Joints;Knowledge;Learning;learning network;Link;Maps;Measures;Methods;Minority;Modeling;multimodality;Necrotizing Enterocolitis;Neonatal Intensive Care Units;New York City;novel;Nursing Staff;Organization administrative structures;Outcome;Ownership;Patient Discharge;patient population;peer;peer learning;peer networks;Performance;Perinatal;Perinatal Care;Personal Satisfaction;Policy Maker;Population;population based;Premature Infant;primary outcome;Process;Public Health;Quality of Care;Race;racial disparity;Reporting;Research;Resources;Risk;Risk Adjustment;Safety;safety net;safety study;Sampling;segregation;Site;Site Visit;social;social factors;Statistical Computing;Structure;Surveys;Time;United States;United States National Institutes of Health;Variant;Very Low Birth Weight Infant;Vital Statistics;Vulnerable Populations;Work

PROJECT_TITLE: Revealing and Resolving Institutional Racism in the NICU

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: PROJECT NARRATIVE The influence of positive natural selection in shaping the genomes of southern African populations is largely unknown. In this study, using the most appropriate and accurate statistical method, we will scan large-scale whole genome sequencing datasets (> 1000 individuals from ~5 populations) for signals of positive natural selection and characterize the functional importance of identified signals. Ultimately, we aim to detect novel positive selection signals that could have a potential impact on various human phenotypes in a largely understudied population.

PI_NAMEs: UREN, CAITLIN  (contact)

PROGRAM_OFFICER_NAME: POVLICH, LAURA

PROJECT_TERMS: Address;Admixture;Africa;African;African ancestry;Area;Asian population;Biological;Botswana;Catalogs;Censuses;Cholera;Climate;Collection;Color;Dairy Products;Data;Data Set;design;Diabetes Mellitus;Disease;disease phenotype;disorder risk;Environment;European;Eye Color;Food;Future;Genes;Genetic Variation;Genome;genome sequencing;genome wide association study;genomic data;genomic locus;Geography;Gluten;Hair Color;Haplotypes;Health;Height;Historical Demography;HIV;Home;Human;human disease;Human Genome;improved;in silico;Individual;insight;machine learning framework;Malaria;Mentors;Methods;migration;Modeling;Modernization;Namibia;National Human Genome Research Institute;Native-Born;Natural Selections;novel;Pathway interactions;Pattern;Persons;Phase;Phenotype;Population;population genetic structure;pressure;Probability;Process;Resources;Role;Sample Size;Scanning;Shapes;Signal Transduction;Skin Pigmentation;South Africa;South African;Southeastern Asia;Southern Africa;Statistical Methods;statistics;Testing;Training;trait;translational potential;Translational Research;Tuberculosis;Variant;whole genome;Work;Zambia

PROJECT_TITLE: A comprehensive whole genome sequence scan for positive selection in southern Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-J(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative: The quest for a drug that can halt bone loss and subsequent skeletal fragility in the aging population continues. We discovered that inhibition of a protein called IL-17ra in the cells that destroy bone (osteoclasts) in osteoporotic patients led to increased bone mass in small animals. Here we proposed to validate our discovery in aging versus traumatic bone injury.

PI_NAMEs: DRISSI, MOULAY HICHAM (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Acetylation;acute myeloid leukemia 1 protein;Age Months;aged;Aging;aging population;Animals;Anti-Inflammatory Agents;Antigen Presentation;Attenuated;Biological Assay;Biological Products;bone;Bone callus;bone fracture repair;bone fragility;bone healing;bone health;Bone Injury;bone loss;Bone Marrow;bone mass;Bone remodeling;bone repair;Bone Resorption;Bone Resorption Inhibition;cartilaginous;Cell Lineage;Cells;Clinical;conditional knockout;cytokine;Data;density;efficacy evaluation;Enhancers;Evaluation;Exhibits;experimental group;experimental study;Family;Female;Femoral Fractures;Fracture;Genotype;glycol-chitosan;Gonadal Steroid Hormones;Harvest;healing;Histologic;Homeostasis;IL17 gene;Image;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Knock-out;Laboratories;Ligands;Link;LoxP-flanked allele;male;Mechanics;Medicine;Molecular;Mus;Myelogenous;Myeloid Cells;nanoparticle;old mice;Orthopedics;Osteoclasts;Osteoporotic;Outcome Measure;Ovariectomy;overexpression;Patients;peripheral blood;Phagocytosis;Pharmaceutical Preparations;Phase;Phenotype;Play;Population;Proteins;Publications;Publishing;receptor;RNA;Role;Senility;Serum;sex;Signal Pathway;Signal Transduction;skeletal;Skeleton;small molecule;Sorting;Spleen;Tamoxifen;Testing;Therapeutic;Tissues;Transcription Repressor;transcriptome sequencing;transcriptomics;Transgenic Mice;Trauma;Up-Regulation;Work

PROJECT_TITLE: Role of IL-17 receptor A in aging bone remodeling

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pediatric

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Although there have been advances in antiretroviral treatment (ART) for HIV, adolescents and young adults living with HIV (AHIV) continue to have disparate HIV outcomes particularly viral suppression (VS), when compared to other populations likely related to multi-layered challenges (social determinants, cognitive development), system, and biomedical challenges including the reliance on oral ART as the only choice for HIV treatment. Given that approximately 1/3 of AHIV despite being in care fail to attain or sustain VS with resultant individual and public health risk, there is a need to develop real-world implementable interventions that can improve their virologic outcomes. The Strategies to AchieVe Viral Suppression for Youth with HIV (SAVVY) Study aims to 1) optimize personal ART choice by using the HIV-ASSIST clinical program to inform CHOICE counseling regarding an AHIV's preferred approach, including the possibility of long-acting injectable ART (LAI- ART); 2) facilitate access to their preferred choice through deploying a focused team to navigate barriers to attaining LAI-ART; and 3) decipher and address the patient, provider, and systemic barriers to the uptake and routinization of LAI-ART among AHIV by applying an implementation science framework and assessing cost- effectiveness providing critical data to support comprehensive approaches to optimizing ART and VS for AHIV, a key population identified in the Ending the HIV Epidemic in the United States Initiative.

PI_NAMEs: AGWU, ALLISON L (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: 12 year old;Address;Adherence;adherence rate;Adolescent and Young Adult;Adult;Age;antiretroviral therapy;Baltimore;care delivery;Caring;Case Series;Characteristics;Clinic;Clinical;cognitive development;comorbidity;comparison intervention;Consolidated Framework for Implementation Research;Continuity of Patient Care;cost;Cost Analysis;cost effective;cost effectiveness;cost-effectiveness ratio;Counseling;Data;Decision Making;Diagnosis;Disease Progression;Disparity;disparity reduction;Dose;Economics;Eligibility Determination;Enrollment;Epidemic;epidemiological model;Epidemiology;Exclusion;Friends;Goals;Health;health related quality of life;Healthcare Systems;HIV;HIV diagnosis;HIV disparities;Immune;implementation barriers;implementation framework;improved;incremental cost-effectiveness;Individual;Injectable;Injections;innovation;interest;Intervention;Knowledge;Life;mathematical model;meetings;novel;older adult;Oral;Outcome;Outcome Study;patient-level barriers;Patients;Pharmaceutical Preparations;Population;preference;programs;Provider;provider-level barriers;psychosocial;Public Health;Publishing;Regimen;Reporting;Risk;scale up;Services;social determinants;Structure;Surveys;System;systemic barrier;Tablets;Time;tool;transmission process;treatment adherence;treatment choice;Treatment Protocols;treatment strategy;Uncertainty;United States;uptake;Viral;Viral Load result;Viremia;young adult;Youth

PROJECT_TITLE: Strategies to Achieve Viral Suppression for Youth with HIV (The SAVVY Study)

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: TAMPA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative Intracerebral hemorrhage (ICH), the deadliest form of stroke, causes high rates of death and long-term disability worldwide. This proposal investigates the biological functions of fibroblast-derived laminin in blood- brain barrier (BBB) repair and fibroblast biology after ICH. Successful completion of this proposal will: (1) elucidate the fundamental roles of fibroblast-derived laminin in BBB repair and fibroblast biology after ICH; and (2) identify the receptors that mediate these effects on endothelial cells and fibroblasts, which will provide new molecular targets with therapeutic potential and promote the development of innovative and effective treatments for ICH.

PI_NAMEs: YAO, YAO  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Ablation;Adherens Junction;Affect;Apoptosis;Basal lamina;Biological Process;Biology;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;brain endothelial cell;Brain hemorrhage;Brain Injuries;Cause of Death;cell type;Cells;central nervous system injury;Cerebral hemisphere hemorrhage;Cerebrovascular system;Cessation of life;Cicatrix;clinically relevant;cognitive function;Death Rate;density;Development;disability;Disease Outcome;effective therapy;Endothelial Cells;Fibroblasts;Fibronectins;Foundations;Gender;genetic approach;improved;In Vitro;in vivo;Infarction;Infiltration;Inflammatory;Injury;injury and repair;innovation;Innovative Therapy;Knowledge;Laboratories;Laminin;laminin S;Learning;Long term disability;long term memory;Mediating;Meninges;middle age;migration;Mission;Modeling;Molecular;Molecular Target;Molecular Weight;Morphology;Mus;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Neurologic;neuroprotection;novel;Outcome;Pathogenesis;pharmacologic;Physiological;Play;Population;Prevention strategy;Proliferating;Protein Isoforms;Proteins;receptor;repaired;Research;Role;Secondary to;Sensorimotor functions;single-cell RNA sequencing;Stroke;Testing;Therapeutic;Time;Tracer;transcriptome sequencing;transcytosis;Transgenic Mice

PROJECT_TITLE: Fibroblast-derived laminin regulates blood-brain barrier integrity and fibroblast biology in hemorrhagic brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-M(91)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Lung;Primary Health Care

ORG_CITY: WINSTON-SALEM

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narratives (3 sentences) Shared decision making (SDM) is a patient-centered process in which patients and providers work together to make decisions and select tests, treatments, and care plans based on evidence that balances risks with patient preferences and values. Here we will evaluate the implementation of Coach McLungsSM, a virtual evidence- based asthma SDM intervention integrated into the electronic medical record, into primary care practices across Atrium Health, a large healthcare system. After convening a Stakeholder Advisory Committee composed of researchers, patients, and stakeholders expert in implementation science and asthma advocacy, we will implement and evaluate the Coach McLungsSM SDM intervention into primary care practices where providers will be trained in SDM communication and use of Coach McLungsSM to evaluate asthma outcomes and ways to improve practice implementation.

PI_NAMEs: TAPP, HAZEL  (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: acute care;Adoption;Advisory Committees;Advocacy;Affect;Age;aged;Asthma;asthmatic patient;Back;Caring;Cessation of life;Child;Chronic Disease;Clinical;clinical decision support;Communication;Complex;Computerized Medical Record;Consolidated Framework for Implementation Research;Decision Making;Disparity;Education;Emergency department visit;Ethnic Origin;Evaluation;evidence base;Family;Feedback;Funding;Gender;Goals;Health;Health behavior change;Health Personnel;Health Policy;Health system;Healthcare;Healthcare Systems;Heart Atrium;Hospitalization;implementation evaluation;implementation facilitators;implementation science;implementation strategy;improved;improved outcome;Individual;inflammatory lung disease;Integrated Health Care Systems;Intervention;Knowledge;Measures;Medical;meetings;Methods;Morbidity - disease rate;mortality;multidisciplinary;operation;Oral;Outcome;patient oriented;Patient Preferences;Patient-Focused Outcomes;Patients;pediatric patients;Persons;practice-based research network;Primary Care;primary care practice;Process;process improvement;Provider;Race;randomized, controlled study;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Design;Research Institute;Research Personnel;Risk;shared decision making;Socioeconomic Status;Steroids;System;Testing;tool;Training;United States;uptake;virtual;Visit;Work

PROJECT_TITLE: Primary care Implementation and evaluation of Coach McLungs™ an asthma shared decision-making intervention, across a large healthcare system

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Our research focuses on the gas exchange region of lung, which is the site of injury in respiratory failure. By learning how resident cells are activated to repair injury, we may be able to apply this knowledge to develop new and effective treatment approaches for respiratory failure.

PI_NAMEs: DESAI, TUSHAR JASUBHAI (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: 3-Dimensional;Ablation;Activities of Daily Living;Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Adrenal Cortex Hormones;Adult;Aging;AGTR2 gene;Alleles;Alveolar;Alveolar Cell;alveolar epithelium;Anti-Inflammatory Agents;Antibiotics;Bacterial Pneumonia;beta catenin;Biology;Blood capillaries;Blood Vessels;Capillary Endothelial Cell;Cause of Death;Cell Differentiation process;cell growth regulation;cell injury;cell killing;Cell Proliferation;cell regeneration;cell type;Cells;Cessation of life;Chronic;comparative;Cytokinesis;Data;effective therapy;EGFR inhibition;Electrons;Endothelial Cells;Endothelium;Engineering;Epidermal Growth Factor Receptor;epithelial repair;Epithelium;epithelium regeneration;Failure;Fibroblasts;Functional disorder;Gases;Goals;Hand;Hyperplasia;Hypoxemic Respiratory Failure;Impairment;Individual;Influenza A Virus, H1N1 Subtype;influenza pneumonia;Injury;injury and repair;Kinetics;Knowledge;Learning;Liquid substance;Lung;Maintenance;Maps;Measures;Mechanical ventilation;Microscopic;Mitosis;Modeling;Molecular;molecular dynamics;molecular targeted therapies;Mononuclear;mouse genetics;Mus;Natural regeneration;novel;Nuclear;Outcome;Oxygen;Pathogenesis;Pathologic;Permeability;Pharmaceutical Preparations;Phenotype;Physiologic pulse;Physiological;Population;prevent;Process;progenitor;programs;Proliferating;Property;Pulmonary Edema;reconstitution;regenerative;Regenerative response;repaired;Research;Resolution;Respiratory distress;Respiratory Failure;response;restoration;Series;Signal Transduction;Site;spheroids;stem cell proliferation;stem cells;Structure;supplemental oxygen;surfactant function;temporal measurement;Testing;tool;transcriptome sequencing;transdifferentiation;Vascular Permeabilities;WNT Signaling Pathway;Work

PROJECT_TITLE: Cellular and molecular mechanisms of alveolar repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-Q(03)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LAS VEGAS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: PROJECT NARRATIVE There are substantial unmet needs of patients with Alzheimer’s Disease and Related Dementias (ADRD) that can be addressed by advances in entrepreneurship, understanding of non-academic research-based careers, and promoting academic programs in the ADRD drug development ecosystem. The UNLV Brain Health Innovation Incubator (InnovaTor) will develop comprehensive programs including seminars, lived experiences, internships, and team projects focusing on these three themes. UNLV is a minority-serving institution and is committed to inclusive involvement of diverse participants from UNLV and other educational institutions in InnovaTor activities.

PI_NAMEs: CUMMINGS, JEFFREY L. (contact);SCHWARTZ, JAMIE

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: academic program;Achievement;Address;Advocacy;aging population;Agreement;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Asian Americans;biopharmaceutical industry;Biotechnology;Black American;brain health;Businesses;Capital;career;Career Choice;Career Mobility;Caring;Clinical Trials;commercialization;Communities;Complex;Development;Doctor of Philosophy;drug development;Economic Development;Ecosystem;editorial;Education;Educational Curriculum;Employment;Entrepreneurship;Exercise;experience;Faculty;Family;Funding;Goals;Government;Grant;Hispanic Populations;Hispanic-serving Institution;Immersion;improved;Incubators;Individual;Industry;Infrastructure;innovation;insight;Institution;Instruction;Intellectual Property;interest;Internships;Investments;Journalism;Knowledge;Laws;Leadership;Learning;Licensing;Lived experience;Marketing;Medical;mild cognitive impairment;minority student;Minority-Serving Institution;Native Americans;Neurologist;Nonprofit Organizations;operation;outreach;Pacific Island Americans;Participant;Patients;pharmacovigilance;Policies;Population Heterogeneity;pre-clinical;Principal Investigator;Problem Solving;Process;Productivity;programs;Public Health;Regulatory Affairs;Research;Research Personnel;Resources;Role;Schools;Science;Secure;Series;Small Business Innovation Research Grant;Small Business Technology Transfer Research;southern nevada;Structure;Students;synergism;undergraduate student;United States National Institutes of Health;Writing

PROJECT_TITLE: Alzheimer's Disease and Related Dementias Innovation Incubator (InnovaTor)


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Health Services;Infectious Diseases;Primary Health Care

ORG_CITY: HOUSTON

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative There is a great need to reduce inappropriate antibiotic prescribing by dentists. In this project we seek to first use data from electronic health records to measure how often dentists prescribe antibiotics inappropriately. We then seek to understand the reasons why dentists prescribe outside clinical guidelines at two large dental institutions, and then develop solutions to improve prescribing practices.

PI_NAMEs: RINDAL, D. BRAD;SUDA, KJ ;WALJI, MUHAMMAD  (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Adverse event;Aftercare;Algorithms;Allergic Reaction;American Dental Association;Antibiotic Prophylaxis;Antibiotics;Antimicrobial Resistance;arm;Behavior;Characteristics;Clinic;Clinical;clinical decision support;Clostridium difficile;computerized;dashboard;Data;Dental;Dental Care;Dental General Practice;Dental Informatics;Dentistry;Dentists;design;Development;Diagnosis;Discipline;electronic health data;Electronic Health Record;Engineering;Environment;evidence base;Feedback;Fostering;Funding;Future;Goals;Group Practice;Guidelines;Health;health care quality;Health system;Healthcare;high risk;Human;human centered design;improved;Infection;Informatics;informatics infrastructure;innovation;Institution;Intervention;Interview;Knowledge;Learning;Measures;medical specialties;National Institute of Dental and Craniofacial Research;novel strategies;Occupations;Oral health;Outcome;Patients;Performance;Pharmacology;preservation;Procedures;Process;Productivity;prophylactic;Prophylactic treatment;Provider;Qualifying;Recommendation;Research;Safety;Support System;synergism;System;Testing;Time;tool;United States Agency for Healthcare Research and Quality;uptake;Visit;Work

PROJECT_TITLE: Informatics Approaches to Understand and Reduce Inappropriate Antibiotic Prescribing by Dentists

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Hypertension;Mental Health;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: BURLINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: The proposed research is highly relevant to public health, reflecting the fact that psychological stress is a major risk factor for hypertension and cardiovascular disease. This proposal investigates novel signaling mechanisms that induce both morphological and functional transformations of the neuronal circuitry in the hypothalamus, a brain region that plays a central role in orchestrating cardiovascular responses to stress. The long-term goal of our studies is to identify novel therapeutic targets for treating hypertension associated with psychological stress.

PI_NAMEs: ERDOS, BENEDEK  (contact);WESTON, MATTHEW C

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: acute stress;Animals;Anti-Hypertensive Agents;biological adaptation to stress;Blood flow;Blood Pressure;blood pressure elevation;blood pressure reduction;Blood Vessels;Brain;Brain region;Brain-Derived Neurotrophic Factor;Cardiac;Cardiovascular Diseases;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Characteristics;Chronic;Chronic stress;clinically relevant;Complex;Conscious;coping;COVID-19;Data;density;Development;Electrophysiology (science);Equilibrium;experimental study;Female;FRAP1 gene;Future;genetic manipulation;Glutamates;Goals;Hypertension;hypertensive;Hypothalamic structure;Immunofluorescence Immunologic;In Vitro;in vivo;Individual;Life;male;Measures;Mediating;Metabolic;Modeling;Modernization;Monitor;Morphology;multidisciplinary;neural circuit;neuronal cell body;neuronal circuitry;neuronal excitability;Neuronal Plasticity;Neurons;Neurosecretory Systems;neurotransmission;new therapeutic target;normotensive;novel;Organ;Organism;Output;paraventricular nucleus;patch clamp;Pathway interactions;Physiological;Play;Predisposition;prevent;psychologic;Psychological Stress;psychological stressor;Public Health;Rattus;Regulation;renal damage;Research;response;Risk;Risk Factors;Role;sensor;Signal Transduction;Slice;Social isolation;Societies;Socioeconomic Status;Spinal;Stimulus;Stress;stressor;Sympathetic Nervous System;Synapses;Synaptic Transmission;Techniques;Telemetry;Testing;therapeutic target;transmission process;Viral Vector;Work

PROJECT_TITLE: Hypothalamic BDNF-mTOR signaling promotes hypertension by increasing cardiovascular sensitivity to stress

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: We discovered the important role of TFEB, the master transcription factor of autophagy and lysosome biogenesis, in host defense response to coronavirus infection. We developed small molecule E3 ligase subunit DCAF7 inhibitor to maintain TFEB protein levels, activate lysosome and enhance HCoV clearance both in cellular models and in K18-hACE2 SARS-CoV-2 mouse model. We propose that this novel strategy of activating lysosome to boost host defense can serve as an off-the-shelf therapy for the next coronavirus pandemic.

PI_NAMEs: BARRATT-BOYES, SIMON M;LIU, YUAN  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Affinity Chromatography;Animal Model;Anti-viral Agents;Anti-viral Response;Attenuated;Autophagocytosis;Bacteria;betacoronavirus;Biogenesis;Cell model;Cell Physiology;Cells;Cessation of life;Characteristics;Chemistry;Common Cold;Coronavirus;coronavirus disease;Coronavirus Infections;coronavirus pandemic;coronavirus therapeutics;Coupled;COVID-19;COVID-19 pandemic;COVID-19 therapeutics;COVID-19 treatment;Critical Pathways;current pandemic;defense response;Degradation Pathway;Development;Disease Outbreaks;drug discovery;Drug Targeting;efficacy testing;empowerment;Endocytosis;Epithelial Cells;Eukaryota;Functional disorder;Future;future pandemic;Gene Expression;gene network;genetic evolution;Homeostasis;Host Defense;Housekeeping;human coronavirus;Immune;in silico;Infection;inhibitor;Innate Immune Response;innovation;Invaded;K-18 conjugate;Lead;Libraries;Life;Life Cycle Stages;Lung;lung injury;Lysosomes;Macrophage;Mass Spectrum Analysis;Mediating;Middle East Respiratory Syndrome Coronavirus;Molecular;molecular modeling;mouse model;Mutation;Natural Immunity;neutralizing antibody;novel;novel coronavirus;novel strategies;novel therapeutics;Nuclear;Nuclear Translocation;pathogen;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Play;preservation;Process;programs;prophylactic;protein degradation;Proteins;Quality Control;Regulation;Reporting;resilience;Respiratory Tract Infections;RNA Viruses;Role;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 variant;Scheme;Severe Acute Respiratory Syndrome;small molecule;small molecule inhibitor;stem;Structure;targeted treatment;Technology;Therapeutic antibodies;Transcription Coactivator;transcription factor;Transgenic Mice;ubiquitin-protein ligase;Ubiquitination;vaccine development;Vaccines;Variant;variants of concern;Viral;Viral Load result;Viral Proteins;Virulent;Virus;Virus Diseases;Work

PROJECT_TITLE: Host Defense Small Molecule Development for COVID-19 Treatment by Targeting Lysosome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(81)]


ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Programmed cell death known as apoptosis is important process to prevent production and release of progeny virus from virus-infected cells. We will test the hypothesis that RNase enzyme Dicer, which produces small silencing RNAs, is converted from RNase (day-job) to DNase (death-job) to facilitate the apoptosis process in the anti-viral defense system.

PI_NAMEs: FUKUNAGA, RYUYA  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Affect;Animals;antiviral immunity;Apoptosis;Apoptotic;Biochemical;C-terminal;Caenorhabditis elegans;CASP3 gene;Caspase;Cell Death;Cell Line;Cell Physiology;Cells;Cessation of life;Chromatin Structure;Collaborations;CRISPR/Cas technology;Deoxyribonucleases;design;Development;Dicer Enzyme;DNA;Double-Stranded RNA;Endonuclease I;Enzyme Kinetics;Enzymes;Evolution;Exhibits;experimental study;Foundations;Future;genome editing;Human;Length;Link;Mammals;Mediating;MicroRNAs;Molecular;novel;Occupations;Pathway interactions;Physiological;prevent;Process;Production;Proteins;Proteolysis;Ribonuclease III;Ribonucleases;RNA Interference;Role;Small Interfering RNA;Small RNA;System;TdT-Mediated dUTP Nick End Labeling Assay;Testing;Tube;Viral;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Dicer DNA nickase activity and its role in anti-viral immunity in human cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-G(02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: NARRATIVE The Cincinnati Children’s K12 Pediatric Clinical Pharmacology Program will provide the essential resources to expand the critically small pool of pediatric clinical pharmacologists by training a diverse group of junior faculty to become the next generation of independent investigators in the field of Pediatric Clinical Pharmacology. The K12 Scholars will be equipped to lead the development of innovative clinical pharmacology approaches that transform the use of medications in pediatrics. The program will further advance the mission to implement personalized pediatric therapeutics to improve clinical outcomes of children.

PI_NAMEs: GLAUSER, TRACY A;TANG GIRDWOOD, SONYA C (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: Active Learning;Appointment;Area;Award;career development;Child;Childhood;Clinical Pharmacology;Collaborations;Competence;Congresses;design;Development;drug action;Drug toxicity;Educational process of instructing;effective therapy;Environment;experience;Faculty;Fellowship;Funding;Grant;Health;Healthcare;improved;K-Series Research Career Programs;Knowledge;Leadership;leadership development;lectures;Manuscripts;Medical center;Mentored Clinical Scientist Development Program;Mentors;Mentorship;next generation;novel therapeutics;Outcome;patient population;Pediatric Hospitals;pediatric patients;Pediatrics;personalized therapeutic;Pharmaceutical Preparations;Pharmacogenetics;Pharmacology;pharmacometrics;Pharmacotherapy;Positioning Attribute;programs;Research;Research Infrastructure;Research Personnel;Research Training;Resources;responsible research conduct;Site;skills;Societies;symposium;Time;Training;Training Activity;Training Programs;Translations;United States Food and Drug Administration;United States National Institutes of Health;Universities

PROJECT_TITLE: Clinical Pharmacology K12 Training Program


NIH_SPENDING_CATS: Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative:  The goal of this proposal is to determine distinct cellular and molecular mechanisms involved in lung alveolar epithelial homeostasis and repair. We believe this will shed light on the pathogenesis of lung diseases resulting from abnormal homeostasis or failed repair, and further identify drug targets that specifically modulate these processes and improve the disease outcomes.

PI_NAMEs: LIU, YURU  (contact)

PROJECT_TERMS: 3-Dimensional;Alveolar Cell Type I;alveolar epithelium;alveolar homeostasis;alveolar type II cell;Alveolus;Area;Bacterial Infections;Behavior;Bleomycin;Carbon Dioxide;CD44 Antigens;CD44 gene;Cell Physiology;Cells;Chronic lung disease;Data;Disease Outcome;Drug Targeting;Epithelial Cells;epithelial injury;epithelial stem cell;Epithelium;Event;Failure;Fibrosis;Goals;Homeostasis;Human;Immune;Immunity;improved;Injury;injury and repair;Knock-out;Lung;Lung Diseases;lung injury;lung repair;Maintenance;Mediating;Modeling;Molecular;Mus;Mutant Strains Mice;Natural regeneration;new therapeutic target;Organoids;Pathogenesis;Pathway interactions;Phenotype;Population;prevent;Process;Property;Pulmonary alveolar structure;Pulmonary Emphysema;pulmonary function;Regulation;repair function;repaired;Role;self-renewal;Signal Pathway;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;STAT1 gene;STAT3 gene;stem cell function;stem cells;stemness;Subgroup;Surface;surfactant;Testing;transcriptome sequencing;Type II Epithelial Receptor Cell

PROJECT_TITLE: Regulation of type II cells in the repair of alveolar epithelial injury


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Columbus

ORG_DEPT: GENETICS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: This proposal examines a potential link between a cytoplasmic ribonucleoprotein granule, known as the Processing-body, and the microtubule network of eukaryotic cells. The experiments herein will test whether the process of tubulin autoregulation occurs within these granules and may therefore provide valuable insight into this form of regulation. This process has been studied for more than forty years but the machinery responsible for the mRNA degradation had not been identified.

PI_NAMEs: HERMAN, PAUL K (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Appearance;Area;Benomyl;beta Tubulin;Binding;Biological;Biology;Cell Survival;Cells;Cytoplasm;Cytoplasmic Granules;Data;Eukaryotic Cell;Exhibits;experimental study;Family;Gene Expression;Genetic Transcription;Glean;Grant;Homeostasis;insight;Link;Mammals;Meiosis;Membrane;Messenger RNA;Microtubules;Modeling;monomer;mRNA Decay;mRNA Stability;mRNA Transcript Degradation;mutant;Nature;novel;Organelles;Pathway interactions;Phosphorylation;Physical condensation;Physiological;portability;Process;Protein Kinase;Proteins;proteostasis;recruit;Regulation;Resolution;response;Ribonucleoproteins;RNA Polymerase II;Role;Saccharomyces cerevisiae;Signal Transduction;Site;Structure;Testing;Transcript;Translating;Translational Repression;Tubulin;Work;Yeasts

PROJECT_TITLE: An analysis of the regulation and functions of a novel family of membraneless organelles in eukaryotic cells

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ORG_CITY: LA JOLLA

ORG_NAME: PROTEOGENOMICS RESEARCH INSTIT/SYS/ MED

PHR: Project Narrative The overarching goal of the proposed project is to design, develop, and optimize a new class of dual precision therapeutics that are the first to be pumped across the restrictive vascular endothelial cell barrier to achieve high concentrations exclusively inside lung tissue where they can comprehensively block TGF-β, a key signaling cytokine driving inflammation and fibrosis. This lung precision delivery system with active tissue penetration exhibits extraordinary promise at very safe, ultra-low doses and will be rigorously tested in rodent pneumonitis and fibrosis models. It is expected to boost therapeutic potency and efficacy in treating multiple lethal lung diseases that currently lack adequate therapies.

PI_NAMEs: SCHNITZER, JAN EUGENIUSZ (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Address;Affect;Affinity;Animals;Antibodies;Antiinflammatory Effect;arm;Binding;Biodistribution;Biological Markers;Biological Products;Bispecific Antibodies;Bleomycin;Blood Vessels;Cause of Death;Caveolae;Cells;Cessation of life;Chimeric Proteins;Chronic;Clinical;comparative;Convection;COVID-19;Cytokine Signaling;Data;design;Diffusion;Disease;dosage;Dose;Drug Delivery Systems;Drug Targeting;drug testing;efficacy testing;Endothelial Cells;Endothelium;Engineering;Exhibits;expectation;Extravasation;Fibrosis;Foundations;Genetic Engineering;Goals;Histopathology;Hour;human disease;Image;Imaging Techniques;Immunotherapeutic agent;improved;In Vitro;Inflammation;Inflammatory;Intravenous;intravenous injection;Lung;Lung Diseases;Magic;Mediating;Modality;Modeling;Modern Medicine;novel;novel therapeutics;Organ;passive transport;Pathologic;Pathology;Pathway interactions;Penetration;Pharmaceutical Preparations;Phosphorylation;Physiology;Pneumonia;pneumonitis and fibrosis;Pre-Clinical Model;precision drugs;Precision therapeutics;Preclinical Testing;prevent;Property;prophylactic;protein expression;prototype;Pulmonary Inflammation;Pulmonary Pathology;Pump;Rattus;research clinical testing;Research Proposals;response;Rodent;Signal Transduction;single photon emission computed tomography;Site;Specificity;Structure of parenchyma of lung;System;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Therapeutic Index;therapeutic target;therapy outcome;Time;Tissues;Toxic effect;transcytosis;Transforming Growth Factor beta;Treatment Cost;Treatment Efficacy;uptake;Vascular Endothelial Cell;Vascular Endothelium;Work;Workplace

PROJECT_TITLE: Bispecific immunotherapeutic delivery system for lung diseases

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Precision Medicine;Prevention;Radiation Oncology;Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will lead to the development of clinically useful biomarkers that can guide the precise use of bladder preservation therapy for patients with bladder cancer, a well-tolerated treatment that preserves the quality of life of blad- der cancer survivors. It will also advance our understanding of bladder cancer biology with re- spect to mechanisms of treatment resistance, ultimately leading to improvements in bladder cancer therapy. Thus, the proposed research is relevant to the part of the NCI’s Scientific Priori- ties that pertains to treating cancer.

PI_NAMEs: MIYAMOTO, DAVID T. (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Biological Assay;Bladder;Bladder Neoplasm;Blood;Cancer Biology;cancer cell;Cancer Patient;Cancer Survivor;cancer therapy;candidate identification;Cellular Assay;chemoradiation;Clinical;clinical biomarkers;clinical development;Clinical Trials;cohort;Consensus;Cystectomy;Cystoscopy;Data;Development;Disease;Early Diagnosis;Evolution;Expression Profiling;follow-up;Gene Expression Profile;Genetic Transcription;Goals;Guidelines;Image;Immune;improved;improved outcome;innovation;Isodicentric Chromosome;liquid biopsy;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Methodology;Methods;Microfluidics;Modality;Molecular;molecular marker;Molecular Profiling;Monitor;Monitoring for Recurrence;muscle invasive bladder cancer;Neoplasm Circulating Cells;non-invasive monitor;novel;Outcome;outcome prediction;participant enrollment;Patient Monitoring;Patient Selection;Patient-Focused Outcomes;Patients;personalized care;predict clinical outcome;predicting response;Prediction of Response to Therapy;predictive marker;predictive signature;preference;preservation;Primary Neoplasm;Prognosis;Provider;Public Health;Quality of life;radiation response;Radical Cystectomy;rare cancer;Recommendation;Recurrence;Recurrent disease;Recurrent tumor;Relapse;Research;Resistance;resistance mechanism;response;RNA;Selection for Treatments;Southwest Oncology Group;Testing;therapy resistant;tool;transcriptome sequencing;Transurethral Resection;treatment response;tumor;Tumor Markers;Validation

PROJECT_TITLE: Blood-based monitoring of bladder-sparing trimodality therapy for muscle-invasive bladder cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Genetics;Human Genome;Immunotherapy;Microbiome;Precision Medicine

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: NARRATIVE Through rigorous implementation of state-of-the-art, cross-compared technological platforms, we aim to accelerate identification of clinically actionable biomarkers of response, resistance, and adverse events, and define mechanisms at play to guide and improve novel NCI-supported cancer immunotherapy clinical trials.

PI_NAMEs: GNJATIC, SACHA  (contact);KIM-SCHULZE, SEUNGHEE

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Achievement;Administrator;Adverse event;Agreement;Antigens;Architecture;Biological Assay;Biological Markers;biomarker discovery;Biometry;Blood;Cancer Center;cancer clinical trial;cancer immunotherapy;cancer therapy;candidate marker;Cell Therapy;Cells;Characteristics;Clinical;Clinical Trials;clinically actionable;Collaborations;Communities;Complex;complex data;Correlative Study;cost;Dana-Farber Cancer Institute;Data;Data Commons;data integration;data repository;Data Scientist;Data Set;data sharing;Dedications;demographics;design;early phase clinical trial;empowerment;Ensure;exceptional responders;expectation;FDA approved;fitness;Fruit;Funding;Genetic;Goals;Heart;Hematologic Neoplasms;high dimensionality;Human;Human Resources;Immune;immune checkpoint;immune checkpoint blockade;Immunologic Monitoring;Immunologics;Immunologist;Immunooncology;Immunotherapy;immunotherapy clinical trials;immunotherapy trials;improved;innovation;Institution;interest;Joints;Knowledge;Laboratories;Leadership;machine learning method;Malignant Neoplasms;Manuscripts;medical schools;Methodology;microbiome;Mission;Modality;Modeling;Molecular;Molecular Profiling;multidimensional data;multiple omics;Mutation;new therapeutic target;next generation;novel;novel marker;Outcome;Output;Pathologist;Pathology;Pathway interactions;Patients;personalized biomarkers;pharmacodynamic biomarker;Phenotype;Play;Postdoctoral Fellow;Practice Guidelines;Precision cancer therapy;predictive marker;Procedures;Process;Prognostic Marker;programmed cell death ligand 1;programs;Proteomics;Protocols documentation;Recommendation;repository;Reproducibility;Research;Resistance;Resources;response;response biomarker;sample collection;Sampling;Scientist;Serum;single-cell RNA sequencing;Solid Neoplasm;Specialist;Specimen;Standardization;T cell receptor repertoire sequencing;Technology;technology platform;Thinking;Time;Tissues;transcriptome sequencing;transcriptomics;tumor;Tumor Tissue;tumor-immune system interactions;Universities;Viral;Work

PROJECT_TITLE: High-Dimensional Immune Monitoring of NCI-Supported Immunotherapy Trials


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Risk-reducing medications such as tamoxifen and aromatase inhibitors can reduce breast cancer risk among survivors of childhood and adolescent cancer but are not currently standard care for these high-risk women. By using simulation modeling and longitudinal observational data, we will provide estimates of the clinical benefits and harms of risk-reducing medications among high-risk survivors to inform follow-up care guidelines and discussions. This work will reduce morbidity and improve care for survivors by broadening the focus of survivorship care to include primary prevention alongside screening and creating resources that can facilitate care discussions between survivors and care-providers about breast cancer prevention and early detection.

PI_NAMEs: YEH, JENNIFER M. (contact)

PROGRAM_OFFICER_NAME: DIMOND, EILEEN

PROJECT_TERMS: Address;Adolescent;Affordable Care Act;Age;Anthracycline;Area;Aromatase Inhibitors;barrier to care;Black race;BRCA1 Mutation;Breast;Breast Cancer Detection;Breast Cancer Early Detection;Breast Cancer Prevention;Breast Cancer Risk Factor;Cancer Intervention and Surveillance Modeling Network;Cancer Survivor;care providers;Caring;Cessation of life;chemotherapy;Chest;Childhood;childhood cancer survivor;Childhood Cancer Survivor Study;Clinical;clinical care;Clinical Course of Disease;clinically relevant;Cohort Studies;Collaborations;Combination Medication;Communities;comparative;cost;Data;Decision Aid;Decision Modeling;Development;Disparity;Dose;Early Diagnosis;Economics;Elements;Estrogen receptor positive;Exposure to;Face;Female;follow-up;Goals;Guidelines;high risk;High Risk Woman;improved;Incidence;innovation;Internal Medicine;Intervention;Knowledge;Late Effects;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Medicine;Methodology;Modality;Modeling;models and simulation;Morbidity - disease rate;mortality;mortality disparity;mortality risk;mutation carrier;network models;Outcome;Pediatric Oncology Group;Performance;Pharmaceutical Preparations;Postmenopause;Prevention;Prevention trial;Preventive;Primary Cancer Prevention;Primary Prevention;prospective;Publishing;Quality of life;Race;Radiation;Recommendation;Regimen;Research;Resources;Risk;Risk Reduction;routine screening;Saint Jude Children's Research Hospital;screening;screening guidelines;Selective Estrogen Receptor Modulators;Shapes;shared decision making;side effect;Societies;standard care;Survivors;survivorship;Tamoxifen;tumor;United States National Academy of Sciences;United States Preventative Services Task Force;uptake;web site;Woman;Work

PROJECT_TITLE: Can risk-reducing medications improve breast cancer prevention in childhood and adolescent cancer survivors? Comparative modeling to inform care


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Rare Diseases;Stomach Cancer

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Diverse cancers can now be treated by modulating the immune system to recognize and destroy tumor cells; however, only subsets of patients respond to such immunotherapies and tumors often progress despite these efforts. I propose to apply a coupled set of cutting-edge, next-generation in vitro and in vivo methodologies to define the role of somatic mutations in response to cancer immunotherapies in human gastrointestinal cancers. My data will elucidate fundamental biological principles of the tumor-immune interaction, providing a mechanistic framework to inform immunotherapeutic strategies and targets.

PI_NAMEs: LO, YUAN-HUNG  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: 3-Dimensional;adaptive immunity;Air;Anatomy;ARID1A gene;Automobile Driving;Biological;Biology;cancer cell;cancer immunotherapy;Cancer Patient;cancer subtypes;cancer surgery;cancer therapy;Candidate Disease Gene;career;cell killing;Cells;Chromosomal Instability;Coculture Techniques;conventional therapy;Coupled;CRISPR interference;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Cytotoxic Chemotherapy;Data;Detection;Disease;Early Diagnosis;Ecosystem;Engineering;Epithelium;Event;Evolution;Exhibits;Experimental Models;gastric organoids;gastric tumorigenesis;Gene Expression;Generations;Genes;Genetic;genetic approach;Genetic Engineering;genetic manipulation;genome editing;Genome Stability;Genomic approach;Genomics;Genotype;Goals;Human;Human Herpesvirus 4;Immune;immune cell infiltrate;immune checkpoint blockade;Immune Evasion;Immune response;Immune system;immunodeficiency;Immunology;Immunooncology;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vitro Model;in vivo;Infiltration;Inflammatory;insight;Liquid substance;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;malignant stomach neoplasm;Measures;Mediating;Mentors;Methodology;Methods;Microsatellite Instability;MLH1 gene;Modeling;Molecular;Monitor;mouse model;multimodality;mutant;Mutate;Mutation;Natural Immunity;Natural Killer Cells;neoantigens;neoplasm immunotherapy;neoplastic cell;next generation;Normal tissue morphology;novel;novel therapeutics;Oncogenes;Oncogenic;Oncology;Organoids;patient subsets;Patients;pharmacologic;Phase;Phenotype;Physiological;Population;Predisposition;preservation;Proteins;Reaction;Regulation;Research;Research Personnel;Resistance;Resistance development;response;Role;Series;Shapes;skills;Somatic Mutation;success;System;T-Lymphocyte;Technology;Testing;The Cancer Genome Atlas;Therapeutic;tool;TP53 gene;Training;treatment response;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;tumorigenesis;Work;Xenograft procedure

PROJECT_TITLE: Functional characterization of novel oncogenic loci driving progression and immune response in gastrointestinal cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Lung;Nutrition

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE Despite the profound prevalence of asthma, we do not yet have a defined nutritional approach to support disease management. This research will elucidate a novel relationship between how diet effects asthma symptoms and lung function through altering the way our cells use energy. The short-term impact is new fundamental knowledge on the connection between diet, cellular energetics and asthma, while the long- term impact will open new lines of research aimed at using nutrition to improve the treatment and management of asthma, which may elevate patient care and quality of life for individuals with asthma.

PI_NAMEs: MEY, JACOB T (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Address;Adult;Affect;American;Asthma;asthmatic;Award;Bioenergetics;Biological;Biology;Biomedical Research;Biometry;Breathing;career;career development;Caring;Cell Physiology;Cells;Chronic;Clinic;Clinical;clinical application;clinical care;Clinical Management;Clinical Research;clinical translation;Clinical Trials Design;Conduct Clinical Trials;cost;Crossover Design;Data;Defect;Development;Diet;dietary approach;dietary guidelines;Dietitian;Disease;Disease Management;educational atmosphere;Electron Transport;Evolution;Fatty acid glycerol esters;feeding;Functional disorder;Future;Goals;Grant;Growth;Heart Diseases;improved;In Vitro;Individual;individual response;innovation;insight;Intake;inter-individual variation;interest;ketogenic diet;Ketones;Kidney Diseases;Knowledge;Link;Literature;Lung;Lung Diseases;Machine Learning;Medical;Medical Nutrition Therapy;Medium chain triglycerides;Mentored Research Scientist Development Award;Mentors;Mentorship;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Methods;Mission;Mitochondria;mitochondrial metabolism;Modeling;National Heart, Lung, and Blood Institute;novel;Nutrient;nutrient metabolism;nutrition;Nutritional;nutritional approach;Nutritional Study;Nutritional Support;Pathology;Patient Care;Patient-Focused Outcomes;Patients;Permeability;personalized nutrition;Physicians;Plasma;Play;precision nutrition;Prevalence;Productivity;professor;programs;Protons;pulmonary function;Quality of life;Randomized;Recommendation;Recording of previous events;Research;Research Personnel;Respiration;Respiratory Failure;respiratory smooth muscle;response;Role;Scientist;Services;Smooth Muscle Myocytes;Symptoms;Testing;tool;Training;Translational Research;Translations;trial design;vasoconstriction;Writing

PROJECT_TITLE: Individualized Nutrition to Help Asthmatics Improve Lung Function and Energetics (INHALE)


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Social isolation is common among young adults with cancer, which can compromise their psychosocial health. We propose to optimize an evidence-based social connectedness intervention for young adults with cancer and conduct a randomized controlled trial to test its efficacy to improve psychosocial health in this population. This research leverages a highly scalable behavioral intervention to address the unmet psychosocial needs of young adults with cancer.

PI_NAMEs: FREDRICKSON, BARBARA LEE;LAZARD, ALLISON JOAN (contact)

PROGRAM_OFFICER_NAME: EVERSON, NICOLE MARIE

PROJECT_TERMS: Address;Age;Basic Science;Behavior Therapy;Behavioral;cancer diagnosis;Cellular Phone;Communication;compliance behavior;cost;Cues;Data;Data Analyses;demographics;design;digital;digital delivery;digital intervention;effective intervention;Effectiveness of Interventions;emerging adult;Emotional;Emotions;evidence base;Evidence based intervention;experience;experimental study;Goals;Health;health communication;Heavy Drinking;Human;Image;Imagery;improved;Individual;Intervention;intervention effect;Interview;Knowledge;Life;Malignant Neoplasms;Measures;Mediator;Mental Health;Meta-Analysis;mortality;Motivation;multidisciplinary;novel;Obesity;Oncology;Outcome;Participant;peer;Personal Satisfaction;Persons;pilot test;Placebo Control;Population;positive emotional state;post intervention;primary outcome;programs;promote resilience;Protocols documentation;psychologic;psychological distress;Psychology;psychosocial;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;Reproducibility;Research;Risk Factors;Sampling;Science;secondary outcome;sedentary;social;Social Environment;social interventions;Social isolation;social media;Social Psychology;Statistical Models;Symptoms;Testing;Text;theories;therapy design;Tobacco use;Translations;Underserved Population;United States;Visual;Vulnerable Populations;Well in self;Work;young adult

PROJECT_TITLE: Optimizing a Social Connectedness Intervention for Young Adults with Cancer

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative: Motivated by the analysis of big imaging data in the Adolescent Brain Cognitive Development (ABCD) study, in this project, we will develop a set of new Bayesian statistical models to analyze the association between high- resolution images of brain activity and high-dimensional measurements of social environmental factors and clinical variables. These models will allow individual prediction of the risk of beginning substance use, and will identify important imaging biomarkers that are associated with substance use patterns. 1" "

PI_NAMEs: JOHNSON, TIMOTHY D;KANG, JIAN  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Affect;Age;Algorithms;Bayesian Analysis;Bayesian Method;Bayesian Modeling;Behavioral;Big Data;Biological;Brain;Brain imaging;Cations;Child;Child Health;Childhood;Clinical;Clinical Research;cluster computing;cognitive development;Complex;Computational algorithm;Computer software;computerized tools;Data;Data Analyses;Dependence;Development;Discipline;Electronic Health Record;Environmental Risk Factor;Etiology;experience;feature selection;Frequencies;Functional Magnetic Resonance Imaging;Funding;Goals;high dimensionality;High Performance Computing;high resolution imaging;high risk;High-dimensional Modeling;Human;Human Genome;Image;imaging biomarker;imaging modality;Individual;innovation;Intervention;Joints;Knowledge;large-scale imaging data;Longitudinal Studies;Magnetic Resonance Imaging;Maps;Measurement;Mediating;Mediation;Medicine;Methods;Modeling;Modernization;Modification;Multimodal Imaging;neural network;Neural Network Simulation;neuroimaging;Neurosciences;novel;Outcome;parallel computer;Pathology;Pattern;Performance;precision medicine;predict clinical outcome;predictive modeling;Process;Psychology;Psychopathology;Research;Rest;Risk;risk prediction;Route;Sample Size;screening;Seminal;sleep pattern;Smoking;social;social factors;social media;Sports;Statistical Data Interpretation;Statistical Methods;Structure;substance use;Substance Use Disorder;Technology;tool;translational applications;Translational Research;United States;United States National Institutes of Health;user friendly software;vector;Video Games;web based software;web page;Work;young adult;Youth

PROJECT_TITLE: Scalable Bayesian methods for big imaging data analysis

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Nanotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE A major impediment to developing effective therapeutics after spinal cord injury and other neurological disorders is that therapeutics that target one cell type may be contraindicated for another cell type, thereby masking any potential beneficial effects. In this proposal, we will address this issue by utilizing single-cell transcriptomics and proteomics data of the spinal cord injury site to bioinformatically identify compounds that are predicted to reverse the disease phenotype in a cell-type and cell-state-specific manner. These compounds will be targeted to specific cell types using nanoparticle-based drug delivery systems that minimize off-target effects.

PI_NAMEs: AYAD, NAGI G;LEE, JAE K (contact);LEE, KIBUM

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Address;Attenuated;axon growth;axon regeneration;Behavioral;Bioinformatics;Cell surface;cell type;Cells;Cicatrix;Data;Data Set;Disease;disease phenotype;Drug Delivery Systems;drug discovery;Fibroblasts;Fibrosis;Gene Expression;Gene Expression Profile;Goals;Heterogeneity;Hybrids;In Vitro;in vivo evaluation;Individual;Injury;Laboratories;Libraries;lipid nanoparticle;Macrophage;Malignant Neoplasms;Microfluidics;Modality;Modeling;mouse model;Mus;nanoparticle;nanoparticle drug;Nanotechnology;Natural regeneration;Nervous System Disorder;Network-based;Neurons;new technology;novel;novel therapeutics;Oligodendroglia;Pathology;Pharmaceutical Preparations;Phenotype;Polymers;Process;Proteins;Proteomics;Recovery;repaired;Reporting;Research;response;RNA;single-cell RNA sequencing;Site;small molecule;spatiotemporal;Specificity;Spinal cord injury;Stimulus;targeted delivery;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissues;tool;transcriptomics;Treatment Efficacy;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: Targeting cell-type specific disease phenotypes to promote CNS repair


NIH_SPENDING_CATS: Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE African American men are immensely affected by prostate cancer, often diagnosed at an earlier age and with advanced disease. Our work has established a link between metabolic rewiring and defects in the DNA damage response that drives biological disparities in African American prostate cancer patients. Findings from this study will identify metabolic underpinnings and provide a new avenue for biomarker development and targeted cancer therapeutics for African American men.

PI_NAMEs: KRIEGER, KIMIKO  (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: 2'-Deoxythymidine;advanced disease;Affect;African American;Age;American;Anabolism;Automobile Driving;base;Base Excision Repairs;Biochemical;Biological;Biological Factors;Biological Markers;biomarker development;Biopsy;cancer diagnosis;cancer health disparity;Cancer Patient;Carbon;Clinical;clinically relevant;cofactor;cohort;Collection;Communities;Data;Data Set;Defect;Deoxyuridine;Detection;detection method;Diagnosis;Dietary Questionnaires;Disease;Disease Outcome;Disparity;DNA Damage;DNA lesion;DNA Repair;DNA Sequence Alteration;Enzymes;European;Excision;Excision Repair;Exhibits;Folic Acid;Functional disorder;Genetic;Genomic Instability;Germ Lines;Homocysteine;Immunofluorescence Immunologic;Immunohistochemistry;In Vitro;in vivo;inhibitor;inhibitor therapy;knock-down;Lesion;Link;Logistic Regressions;Logistics;Malignant neoplasm of prostate;Malignant Neoplasms;Malnutrition;Mass Spectrum Analysis;Measures;Mediating;men;Metabolic;Metabolism;Methionine;Methylenetetrahydrofolate reductase (NADPH);Modeling;Molecular;Neoplasm Metastasis;novel;nucleotide metabolism;Outcome Measure;Pathway interactions;patient stratification;Patients;Plasma;prostate cancer cell;prostate cancer progression;prostate cancer risk;Prostatectomy;Prostatic Neoplasms;Proteins;Pyrimidine;Recurrence;Regulation;repair function;repaired;Resistance;response;Risk;Role;Sampling;Scaffolding Protein;small hairpin RNA;Socioeconomic Factors;Stress;Therapeutic;Therapeutic Intervention;thymidylate;Thymidylate Synthase;tumor;tumor growth;United States;Up-Regulation;Uracil;Vitamin B 12;Work;XRCC1 gene

PROJECT_TITLE: DELINEATING THE ROLE OF THE HOMOCYSTEINE-FOLATE-THYMIDYLATE SYNTHASE AXIS AND URACIL ACCUMULATION IN AFRICAN AMERICAN PROSTATE TUMORS


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The goal of this project is to expand the NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL) platform for genomics and biomedical research. The research enabled by this platform will accelerate our understanding of the genetic components of human health and disease as well as accelerate progress towards implementing genomic knowledge in medical practice supported by the AnVIL Clinical Resource (ACR). This will be accomplished through improvements to the core AnVIL platform for scalability, usability, and interoperability, the addition of several new scientiﬁc services to make researchers more eﬃcient, and a multi-faceted approach to training and outreach.

PI_NAMEs: AFGAN, ENIS ;CAREY, VINCENT JAMES;ELLROTT, KYLE ;GOECKS, JEREMY ;HOFFMAN, AVA MARIE;LEEK, JEFFREY T.;NEKRUTENKO, ANTON ;SCHATZ, MICHAEL  (contact);TAN, FREDERICK J;TAYLOR, CASEY OVERBY;WALDRON, LEVI

PROGRAM_OFFICER_NAME: WELLINGTON, CHRISTOPHER

PROJECT_TERMS: Acceleration;Bioconductor;Biomedical Research;Clinical;Clinical Research;cloud based;Cloud Computing;Collaborations;Communities;community partnership;Complex;computing resources;cost;cost efficient;dashboard;Data;data access;data harmonization;data ingestion;Data Science;design;Development;Disease;Education;Education and Outreach;Educational Curriculum;Educational process of instructing;Educational workshop;empowerment;Engineering;Ensure;Environment;Ethnic Origin;Event;experience;Galaxy;Genetic;Genome;genomic data;genomic platform;Genomics;Genotype-Tissue Expression Project;Goals;Health;Human;improved;Individual;Informatics;Infrastructure;innovation;interoperability;Joints;Knowledge;Leadership;Lifting;Machine Learning;machine learning model;massive open online courses;Medical;Mendelian disorder;Metadata;Methods;Minority-Serving Institution;Modeling;Monitor;Monograph;National Human Genome Research Institute;Needs Assessment;new technology;next generation;online delivery;outreach;Participant;Persons;Phase;programs;Property;Publishing;reference genome;repository;Research;Research Personnel;Resources;Running;Sampling;scientific computing;Secure;Services;Slide;Software Engineering;Software Tools;Students;success;System;systems research;task analysis;telomere;Tissues;tool;Training;Translating;usability;Variant;Visualization;Work

PROJECT_TITLE: Expanding the AnVIL (Analysis, Visualization, and Informatics Lab-space)


ORG_CITY: ROCHESTER

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative The genomes of most organisms, including humans, harbor a variety of so-called selfish genetic elements that enhance their own transmission by subverting normal reproduction and, in doing so, often contribute to genome evolution, genome instability, mutation, and host infertility. We will study the genetics, molecular mechanisms, and genomic consequences of a selfish meiotic drive element that distorts fair Mendelian transmission of sex chromosomes by killing non- carrier spermatids during spermatogenesis and biasing progeny sex ratios. We will determine how this meiotic drive system has given rise to a network of new genes and regulatory interactions, shaped the evolution of the sex chromosomes, and influenced speciation, the process by which one species split into two reproductively incompatible descendant species.

PI_NAMEs: PRESGRAVES, DAVEN C (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Alleles;arms race;autosome;Binding;chromatin remodeling;Conflict (Psychology);Conflict of Interest;Data;Demography;DNA;DNA Binding;DNA Binding Domain;DNA Sequence;DNA Transposable Elements;Drosophila genus;Elements;Enhancers;Evolution;Experimental Genetics;experimental study;Extinction;Family;Fishes;fungus;Gene Amplification;Gene Family;Genes;Genetic;Genetic Polymorphism;Genetic Recombination;genetic signature;Genetic study;Genome;Genomic Instability;Genomics;Histones;Human;Hybrids;Infertility;Insecta;Invaded;Knock-out;Link;male;male fertility;Mammals;Mediating;Meiosis;Methods;Molecular;Molecular Biology;Mutation;Nucleotides;Organism;Phenotype;Plants;Population;Population Genetics;Predisposition;Process;Production;Protamines;Recording of previous events;Recurrence;Reproduction;reproductive;Research;Research Project Grants;Resistance;Risk;RNA;RNA Interference;Role;Satellite DNA;Selfish Genes;Sex Chromosomes;Sex Ratio;Shapes;Side;Small Interfering RNA;sperm cell;Spermatids;Spermatogenesis;Spermiogenesis;Sterility;Suppressor Genes;System;Testing;Third Generation Sequencing;transmission process;Work;X Chromosome;Y Chromosome

PROJECT_TITLE: Investigating the evolutionary genetics and genomic consequences of sex-ratio meiotic drive in Drosophila

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Neurosciences;Rare Diseases;Stroke;Tuberculosis

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The proposed research is relevant to public health because it focuses on understanding the pathophysiological changes to cerebral vessels in HIV-associated tuberculous meningitis so as to understand the mechanism underlying stroke development and long-term neurological disability. Once the mechanism leading to strokes in TBM is understood, there is the protentional for the development of targeted interventions to reduce the incidence of strokes in HIV-associated tuberculous meningitis. Thus, the proposed research is relevant to NINDS’ mission pertaining to the reduction of long-term neurological disability in neuroinfections.

PI_NAMEs: ABASSI, MAHSA  (contact);MUSUBIRE, ABDU KISEKKA;SCRIVEN, JAMES

PROGRAM_OFFICER_NAME: SRINIVASAN, SUDHA

PROJECT_TERMS: Affect;Age;Basal Ganglia;Blood flow;Blood Flow Velocity;Blood Pressure;Blood Vessels;Brain imaging;brain magnetic resonance imaging;Carbon Dioxide;Caring;Categories;Central Nervous System Infections;Cephalic;cerebral artery;cerebral hemodynamics;Cerebral Infarction;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Physiology;Cerebrovascular system;Cerebrum;Clinical;Clinical Trials;Collaborations;Communicable Diseases;Complication;Death Rate;Development;disability;Disease;Enrollment;experience;follow-up;Functional disorder;functional outcomes;Future;Goals;HIV;HIV Infections;Image;Immune response;Impairment;improved;indexing;Individual;Infection;Inhalation;innovation;Intervention;Knowledge;low and middle-income countries;Magnetic Resonance Imaging;Measurement;Measures;Meningeal Tuberculosis;Meningitis;middle cerebral artery;Minnesota;Mission;Morbidity - disease rate;mortality;Motor;National Institute of Neurological Disorders and Stroke;Necrosis;Nervous System Disorder;Nervous System Trauma;Neurocognitive;Neurocognitive Deficit;neurocognitive test;Neurologic;Neurological disability;Neurological outcome;novel;Outcome;Outcome Assessment;Participant;Pathogenesis;Pathology;Patients;Pattern;Perforating Artery;Performance;Persons;Phase;predicting response;prevent;Productivity;Prospective, cohort study;Public Health;randomized, clinical trials;Research;response;Stimulus;Stroke;stroke incidence;Study Subject;Survivors;Testing;theories;Time;Transcranial Doppler Ultrasonography;Uganda;Universities;Vascular Diseases

PROJECT_TITLE: Cerebral Hemodynamics and Stroke in HIV-associated TB Meningitis.

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine;Women's Health Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative For many patients with cancer, immune checkpoint inhibitors (ICIs) have transformed the course of their diseases; however, only a small subset of patients with breast cancer have benefited from this therapy, in part because of high levels of immunosuppression imposed by myeloid cells in the patient’s tumor. This proposal will determine how treatment with entinostat, an epigenetic modulating drug and inhibitor of histone deacetylase, improves the response to ICIs in metastatic breast cancer via its effects on myeloid immunosuppression and on other suppressive immune cells, tested in mouse models and in samples from breast cancer patients in our clinical trial NCI-9844. The study will reveal new biomarkers and targets for therapy, assisted by a mathematical model that will decipher the complex and collective mechanisms of altered suppression, and predict tumor response to therapy.

PI_NAMEs: ROUSSOS TORRES, EVANTHIA THEODOSIOU (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: advanced breast cancer;Advanced Malignant Neoplasm;Antigen Presentation;Antitumor Response;Automobile Driving;Binding;Biological Markers;biomarker identification;Biopsy;Breast;Breast Cancer Model;Breast Cancer Patient;Candidate Disease Gene;Cell Separation;cell type;Cells;checkpoint inhibition;ChIP-seq;Clinical;Clinical Trials;Co-Immunoprecipitations;Coculture Techniques;cohort;Complex;Couples;Cytometry;Data;Data Analyses;Data Correlations;Dendritic Cells;Differential Equation;Disease;Dose;Drug Modulation;Effector Cell;Epigenetic Process;Evaluation;Flow Cytometry;Frequencies;Future;Gene Expression;Genes;Genomics;Histone Deacetylase Inhibitor;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunosuppression;improved;Infiltration;innovation;Investigation;ipilimumab;Laboratories;loss of function;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;mathematical model;Mediating;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Modeling;models and simulation;Molecular;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;NF-kappa B;Nivolumab;novel;novel strategies;Outcome;patient stratification;patient subsets;Patients;Phase;Phase I Clinical Trials;Phenotype;Play;potential biomarker;pre-clinical;Pre-Clinical Model;preclinical study;predict clinical outcome;promoter;Publishing;Recommendation;Resistance;response;Role;Running;Sampling;Serum;Signal Transduction;single-cell RNA sequencing;Site;Solid Neoplasm;STAT3 gene;T-Lymphocyte;targeted treatment;Testing;Tissue-Specific Gene Expression;Tissues;transcription factor;Transcription Factor AP-1;transcriptome sequencing;treatment response;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages

PROJECT_TITLE: Targeting myeloid suppression to enhance anti-tumor immunity in breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


NIH_SPENDING_CATS: Aging;Cardiovascular;Congenital Heart Disease;Heart Disease;Pediatric;Rare Diseases;Women's Health Research

PHR: The pathological changes in excitation-contraction-bioenergetics coupling contribute to malignant ventricular arrhythmias, both in genetic arrhythmia syndromes and acquired cardiac disease. These studies aim to identify specific molecular targets to reduce the damaging influence of defective calcium signaling on mitochondrial function, and conversely improve mitochondria electron transport to restore aberrant calcium handling. Interruption of the vicious cycle of mitochondria dysfunction and defective intracellular calcium homeostasis is thought have a significant therapeutic potential, reducing arrhythmogenesis and improving contractile function of the heart.

PI_NAMEs: TERENTYEV, DMITRY A (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Acceleration;Adenovirus Vector;Affect;Aging;Animals;Antioxidants;Arrhythmia;Attenuated;Biochemical;Bioenergetics;Bioprobe;Biosensor;Calcium;Calcium Signaling;Calpain;calpain inhibitor;calpastatin;Cardiac;Cardiovascular Diseases;Cardiovascular system;Catecholaminergic Polymorphic Ventricular Tachycardia;Coupling;COX7A2L gene;Crista ampullaris;Diameter;Down-Regulation;Electrocardiogram;Electron Transport;Elements;Event;Extravasation;Female;fluorescence lifetime imaging;gain of function;Generations;Genetic;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Heritability;Homeostasis;Human;Hyperactivity;Hypertrophy;improved;in vivo;Inherited;insight;Interruption;Lead;Link;loss of function;male;Malignant - descriptor;Maps;Mediating;Membrane Potentials;Metabolic;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;mitochondrial membrane;Modeling;Modification;Molecular;Molecular Target;Monitor;mortality;Muscle Cells;novel;novel strategies;OPA1 gene;Optics;Output;oxidation;Pathologic;Peptide Hydrolases;Physiological;Pilot Projects;Play;Premenopause;Process;Production;Proteins;Proteolysis;Rattus;Reactive Oxygen Species;receptor function;Respiration;response;restoration;Risk;Role;Ryanodine Receptor Calcium Release Channel;sex;Sex Differences;sexual dimorphism;Signal Transduction;Stress;Structural Protein;Structure;sudden cardiac death;Syndrome;Tachyarrhythmias;targeted treatment;Testing;Therapeutic;Thoracic aorta;Tissues;Transmission Electron Microscopy;vector;Ventricular;Ventricular Arrhythmia;Visualization;women versus men;women's outcomes;Workload

PROJECT_TITLE: The mechanisms and roles of mitochondria dysfunction in cardiac arrhythmogenesis

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The growing spread of antibiotic resistance has led to an urgent need for new treatments to bacterial infections. While the treatment of bacterial infections with their viruses, bacteriophages, has enormous potential, it is held back by the high levels of specificity of phages for bacterial strains. Here, I will develop a phage therapy treatment that is able to overcome existing bacterial defense mechanisms, one of the key factors driving specificity and thus holding back this therapeutic option.

PI_NAMEs: LEROUX, MICHELE  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Adoption;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;arms race;Automobile Driving;Back;Bacteria;Bacterial Infections;bacterial resistance;Bacteriophages;Biological;Biology;career;Catalogs;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Defense Mechanisms;design;Development;DNA cassette;DNA Restriction-Modification Enzymes;Elements;Engineering;Environment;Escherichia coli;Evolution;experience;flexibility;follow-up;Future;Genome;Genomic approach;Genomics;Growth;high throughput screening;Immune;Immune system;Immunity;Individual;individualized medicine;Infection;innovation;insight;Lead;Libraries;Maps;medical schools;Methods;Mind;Mining;model organism;Molecular;Multi-Drug Resistance;multi-drug resistant pathogen;multidisciplinary;novel;opportunistic pathogen;Organism;pan-genome;Pathogenesis;pathogenic bacteria;Pathway interactions;Patients;Phage Display;Population;Population Heterogeneity;Printing;Process;Production;Pseudomonas aeruginosa;Resistance;Scientist;screening;skills;Specificity;System;targeted treatment;Therapeutic;tool;Training;Universities;Viral;Virus;Vision;Washington;Work

PROJECT_TITLE: Mining the phage playbook to create a potent, generic phage therapy


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Urologic Diseases

ORG_CITY: STANFORD

ORG_DEPT: UROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The overall Multidisciplinary K12 Urology Research at Stanford (KUReS) Career Development Program is to develop the next generation of diverse, highly trained MD, MD/PhD, and PhD scientists to emerge as independent investigators capable of obtaining funding to support their research, leading their area of research in benign urology, and ultimately bring meaningful impact to their field. Having this program embedded in Stanford’s rich culture of innovation and collaboration provides an exceptional environment to empower the next generation of independent investigators who will advance reproductive health for all.

PI_NAMEs: BROOKS, JAMES D.;LIAO, JOSEPH C (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: Address;Advisory Committees;Area;Basic Science;Benign;bridge program;career;career development;clinical care;Clinical Research;Collaborations;Committee Members;Communities;Competence;didactic education;Disease;Doctor of Philosophy;Educational Curriculum;Engineering;experience;Faculty;Functional disorder;Funding;Future Generations;Goals;hands on research;Health;Image;Immersion;Infection;Infrastructure;Interstitial Cystitis;Junior Physician;Leadership;Lesbian Gay Bisexual Transgender Queer;lower urinary tract symptoms;Mentored Clinical Scientist Development Program;Mentors;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Outcome;peer coaching;Physicians;Productivity;Program Development;programs;Qualifying;recruit;Regenerative Medicine;Research;Research Personnel;Research Project Grants;Resources;Schools;Scientist;skill acquisition;skills;Solid;Structure;success;System;Time;Training;Translational Research;United States National Institutes of Health;Urinary Calculi;Urinary tract;urologic;Urology

PROJECT_TITLE: Multidisciplinary K12 Urologic Research at Stanford (KUReS) Career Development Program


NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: MEMPHIS

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: This exploratory R21 grant proposes to generate biocompatible FNTPs and investigate their efficiencies on fluoride delivery into enamel, enhancing remineralization of enamel, and modulation of acid-producing dental biofilms in vitro. Completion of this project will significantly facilitate the development of FNTPs as an innovative approach for prevention and early treatment of dental caries and produce a major impact on the control of dental caries, one of most common human diseases.

PI_NAMEs: HONG, LIANG  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acids;Adult;aged;Animal Model;Area;Argon;Atmosphere;biofilm species;biomaterial compatibility;burden of illness;Caries prevention;cariogenic bacteria;Cells;Childhood;Chronic Disease;Communicable Diseases;Custom;cytotoxicity;Data;deciduous tooth;demineralization;Dental;dental biofilm;Dental caries;Dental Enamel;Dentistry;design;Development;Devices;Disease;Early treatment;Environment;Epithelial Cells;Exhibits;experimental study;Fluorides;Fluorine;Foundations;Free Radicals;Funding;Future;Gases;Generations;Gingiva;Goals;Grant;Growth;hazard;Health;Human;human disease;human old age (65+);Hydroxyapatites;In Vitro;in vitro Model;in vivo;innovation;Interdisciplinary Study;Ions;Knowledge;Literature;Metals;Microbial Biofilms;Modeling;novel;Odontogenesis;Oral;oral biofilm;Oxidative Stress;Penetration;permanent tooth;Persons;Physiological;Plasma;Predisposition;prevent;Prevention approach;Process;Production;Protocols documentation;prototype;Public Health;Publishing;Rattus;Recovery;remineralization;Reporting;Research;Research Project Grants;Selection Criteria;Solid;Sprague-Dawley Rats;Streptococcus mutans;Streptococcus sanguis;Structure;Technology;Temperature;Testing;Tooth Remineralization;Tooth structure;tooth surface;Water fluoridation;Women's study;Work

PROJECT_TITLE: Feasibility of novel Fluorine Non-thermal plasma for dental caries control

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Genetics

ORG_CITY: NORFOLK

ORG_NAME: OLD DOMINION UNIVERSITY

ORG_STATE: VA

PHR: Project narrative  The proposed research will examine how Bone Morphogenic Protein Receptor1α regulates balance of TR and exTR cell subsets to prevent autoimmune diseases. We will investigate how BMP\BMPR1α signaling operates in vivo to regulate tissue tolerance and inflammation.

PI_NAMEs: KRAJ, PIOTR J. (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: activin A;Adhesions;Agonist;antagonist;Antigens;Apoptosis;ATAC-seq;Autoimmune;Autoimmune Diseases;Autoimmunity;Biological Process;BMP2 gene;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;CD4 Positive T Lymphocytes;Cell Aging;Cell Cycle;cell motility;Cell Physiology;Cell secretion;Cell Separation;cell type;Cells;Chromatin Structure;clinically significant;Collaborations;Complex;Cues;cytokine;Data;design;Development;Disease;Down-Regulation;Effector Cell;Epigenetic Process;epigenetic regulation;epigenome;Equilibrium;Family;FOXP3 gene;Gene Expression;Gene Expression Profiling;Generations;Genetic Transcription;HIF1A gene;Homeostasis;IL17 gene;Immune;Immunologics;immunoregulation;In Situ;in vivo;Individual;Inflammation;Inflammatory;inflammatory milieu;inhibitor;insight;Interferon Type II;Maintenance;member;Modification;Molecular;mouse model;Mus;novel therapeutic intervention;overexpression;Pathology;Patients;Peptides;peptidomimetics;Peripheral;peripheral tolerance;pharmacologic;Phenotype;Play;Polycomb;preservation;prevent;programs;Reaction;receptor;Regulatory T-Lymphocyte;Reporting;Research;response;Rheumatoid Arthritis;Role;senescence;Signal Pathway;Signal Transduction;Signaling Protein;T-Lymphocyte Subsets;Testing;Therapeutic;Thymus Gland;Tissues;TNF gene;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Up-Regulation

PROJECT_TITLE: Bone Morphogenic Protein Receptor 1a signaling controls stability of Treg cell phenotype

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Prevention;Telehealth

ORG_CITY: MBARARA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY

PHR: Project narrative Adolescents and young adults with HIV (AYWH) aged 15-24 years are the fastest-growing population of people living with HIV worldwide. AYWH have worse outcomes along the HIV continuum of care than adults with HIV; HIV/AIDS is the second leading cause of mortality and the fourth leading cause of disability among AYWH worldwide. This study will develop an adolescent-tailored, mobile health (mHealth) intervention to improve retention in care and thus has the potential to improve AIDS-related mortality and morbidity among AYWH and decrease new onward transmission.

PI_NAMEs: ADONG, JULIAN  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adolescent Behavior;Adult;Age;aged;Area;Award;Behavior;Behavioral;Behavioral Sciences;care delivery;Caring;Cellular Phone;Childhood;Clinic;Clinical;Clinical Trials;Cognitive;community intervention;Continuity of Patient Care;cost;Data Analyses;Data Collection;Dedications;design;Development;disability;Effectiveness of Interventions;efficacy testing;Emotional;Epidemic;Epidemiology;experience;Fatigue;feasibility testing;flexibility;follow-up;Future;Goals;Health behavior;Health behavior change;Health Priorities;Healthcare;HIV;HIV/AIDS;improved;Infection;innovation;Intention;Intervention;Interview;iterative design;Knowledge;Life;Mental Health;Mentors;mHealth;mhealth interventions;Morbidity - disease rate;mortality;multidisciplinary;Neurobiology;neurodevelopment;Outcome;Perinatal;Persons;pilot test;Planning Theory;poor health outcome;Population;Positioning Attribute;primary outcome;Process;Professional counselor;Randomized;Randomized, Controlled Trials;Research;Research Methodology;Research Training;Resource-limited setting;response;Rewards;Risk Taking;Role;Route;Science;Scientist;Self Efficacy;skill acquisition;skills;social;Social Change;social cognitive theory;social media;Statistical Methods;System;Technology;Testing;theories;therapy development;Training;transmission process;Transportation;Treatment Efficacy;Treatment outcome;Uganda;Universities;usability;Viral;Visit;Visual;Waiting Lists;Work

PROJECT_TITLE: A social media mHealth intervention to improve retention in care for adolescents and young adults with HIV in Uganda

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-J(55)R]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Pathogens in the Rickettsia genus cause an array of potentially fatal arthropod-borne vascular diseases in humans, but their infection mechanisms are poorly understood. The goal of this project is to investigate how two Rickettsia surface or secreted proteins of unknown function promote infection of host cells. Knowledge from this work will improve our understanding of Rickettsia pathogenesis and directly inform the development of diagnostics, therapeutics, and vaccines for these pathogens.

PI_NAMEs: SIT, BRANDON YIU CHUNG (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Adhesions;Affinity Chromatography;Antigens;arthropod-borne;Attenuated;Autophagocytosis;Binding;Bioinformatics;Biology;Cells;Cellular biology;Collagen;Complex;CRISPR/Cas technology;Cytoskeleton;Cytosol;Defect;design;Development;diagnostic development;Dissection;Engineering;Environment;Equipment;Fimbriae Proteins;gene product;Genes;Genetic;genetic approach;genetic manipulation;Genetic Screening;Genome;Genomics;Goals;Human;Imaging Techniques;improved;Infection;innovation;Integration Host Factors;Invaded;Investigation;Joints;Knock-out;Knowledge;Libraries;Life Cycle Stages;Life Style;Link;Lipoproteins;Mentorship;Methods;Microbe;Modeling;Mutagenesis;mutant;Nature;novel;novel therapeutics;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Phenotype;Positioning Attribute;Probability;Protein Secretion;Proteins;Public Health;receptor binding;Reporting;Research Personnel;Resistance;Rickettsia;Rickettsia Infections;Rickettsia parkeri;Rocky Mountain Spotted Fever;Role;screening;spatiotemporal;spotted fever;Surface;System;Techniques;Therapeutic;therapeutic development;Time;tool;Training;Vaccines;Vascular Diseases;Virulence;Work

PROJECT_TITLE: Investigating genes of unknown function required for Rickettsia parkeri infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07B-U(20)]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Kidney Disease;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Membranous nephropathy (MN) is a kidney disease that results from an autoimmune response against the kidney glomeruli. Recently, HTRA1 has been identified as a new antigen in MN. Currently, little is known about the mechanisms by which HTRA1 may trigger autoimmune responses in this disease. This proposal will employ an integrated approach of proteomics and animal studies to characterize HTRA1 epitopes, which might be involved in MN development. The study should extend and expand insights regarding the disease mechanisms of HTRA1- associated MN, as well as establishing a foundation to develop novel peptide-based therapies for this condition.

PI_NAMEs: AL-RABADI, LAITH  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Albuminuria;Animal Model;Animals;Antibodies;Antibody titer measurement;Antigen Targeting;Antigen-Antibody Complex;Antigens;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmune Process;Autoimmune Responses;Automobile Driving;Award;Basement membrane;Binding;Biological Assay;Blood;Brain;Bruch's basal membrane structure;Career Choice;career development;chromatin immunoprecipitation;Circulation;Clinic;Clinical;clinical development;Clinical Research;clinically relevant;cohort;Communication;Data;Deposition;design;Development;Diagnosis;Disease;Education;Electron Microscopy;End stage renal failure;Endothelial Cells;Ensure;Epitopes;Event;experience;Extracellular Matrix;Extracellular Matrix Proteins;Eye;Eye diseases;Filtration;Foundations;Generations;glomerular basement membrane;glomerular filtration;Goals;Heterophile Antibodies;Histologic;Homeostasis;Human;Immune response;Immunization;Immunize;Immunofluorescence Immunologic;Immunology;improved;In Situ;In Vitro;in vivo;Injury;insight;Junior Physician;Kidney;Kidney Diseases;Kidney Glomerulus;Knockout Mice;Knowledge;Laboratories;Leadership;Mediating;Membranous Glomerulonephritis;Mentors;Mentorship;Modeling;Mus;Nephrology;Nephrotic Syndrome;novel;Organ;Oryctolagus cuniculus;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Peptide Hydrolases;Peptides;podocyte;Pre-Clinical Model;Production;programs;Protease Domain;Protein Fragment;protein function;protein protein interaction;Protein Secretion;Proteins;Proteinuria;Proteomics;Renal glomerular disease;Research;Research Personnel;Resources;response;Rodent;Running;Scientist;Serine Protease;Serum;Site;skills;Structure;Testing;Therapeutic;Time;Tissues;Training;Training Activity;Transgenic Model;Treatment outcome;trypsin-like serine protease;Universities;Utah

PROJECT_TITLE: The Serine Protease HTRA1 Antigen: A Gateway to Elucidating Membranous Nephropathy Pathogenesis and the Targeting of Antigen Epitopes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]