NIH_SPENDING_CATS: Aging;Cardiovascular;Childhood Obesity;Clinical Research;Diabetes;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Infectious Diseases;Microbiome;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative  We propose to investigate the underlying immune pathway of the intergenerational link of adverse cardiometabolic outcomes by integrating state-of-the-art antibody profiles to a broad array of pathogenic and commensal microbes and systemic immunoproteomic profiles in a high-risk U.S. racially and ethnically diverse prospective birth cohort. Findings from this study may lead to a new paradigm to halt or reverse the vicious intergenerational cycle of cardiometabolic risk, and to improve health across the lifespan and generations.

PI_NAMEs: WANG, GUOYING  (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 18 year old;Adult;Adverse effects;Affect;Age;Anti-Inflammatory Agents;Antibodies;antibody detection;Antibody Repertoire;Automobile Driving;Biological Assay;Birth;Blood Pressure;blood pressure elevation;Boston;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Child;Childhood;chronic infection;Circulation;Clinical;clinical database;cohort;Cohort Studies;commensal microbes;Communities;cost efficient;cytokine;Data;Development;Diabetes Mellitus;Dyslipidemias;early detection biomarkers;Early identification;Enrollment;Epidemiology;ethnic diversity;ethnic minority population;fetal;Folic Acid;Folic Acid Deficiency;Funding;Future Generations;Generations;Goals;Health;high risk;high risk population;Household;human virome;Hypertension;Immune;Immune response;Immune system;Immunocompetence;Immunoglobulin G;Immunologic Markers;Immunologics;improved;in utero;Individual;Infant;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Insulin Resistance;intergenerational;Life;Life Cycle Stages;life span;Link;Low income;low socioeconomic status;maternal obesity;Mediating;Metabolic;Microbe;Micronutrients;Morbidity - disease rate;Mothers;multi-ethnic;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;Obesity;Obesity Epidemic;Outcome;overweight child;pathogen;pathogenic microbe;Pathway interactions;Phage ImmunoPrecipitation Sequencing;Pre-Eclampsia;Prevalence;Prevention;prospective;protective factors;racial diversity;racial minority population;Research;Resources;Risk Assessment;Role;screening;Technology;Time;transmission process;Umbilical Cord Blood;United States National Institutes of Health;Vitamin B 12

PROJECT_TITLE: Inter-Generational Cardiometabolic Risk: Explore Underlying  Immune Pathways

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE In preparation for a future large randomized controlled trial (RCT) and with active stakeholder engagement, during this proposed planning grant period there will be refinement and then preliminary evaluation of the impact of a tailored mobile optimized psychosocial support tool (named PerCS-YA: Personalized Cancer Support for Young Adults) on cancer-related worry and distress in young adult survivors of thyroid, melanoma, and testicular cancer. By leveraging advances in digital and mobile health and by tailoring the intervention to the young adult population, PerCS-YA has potential to reduce cancer burden and to improve the psychosocial well-being of young adult cancer survivors.

PI_NAMEs: HAWLEY, SARAH T;HAYMART, MEGAN RIST (contact)

PROGRAM_OFFICER_NAME: ACEVEDO, AMANDA MARIE

PROJECT_TERMS: 2 arm randomized control trial;Accounting;Address;Adherence;Adult;Age;age group;Android;Behavior Therapy;Behavioral;Behavioral Model;Behavioral trial;Biometry;Cancer Burden;cancer care;Cancer Center;cancer diagnosis;cancer health disparity;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;cancer type;care delivery;Cellular Phone;Clinical;Clinical Trials;Collaborations;Communication Research;Communities;Consolidated Framework for Implementation Research;Continuing Education;Diagnosis;digital health;Distress;efficacy trial;emotional distress;Ensure;Etiology;Evaluation;Event;experience;Family;Feasibility Studies;Feedback;Focus Groups;Foundations;Funding;Future;Geography;Goals;Grant;handheld mobile device;health communication;Health Technology;Impact evaluation;implementation evaluation;improved;Incidence;Individual;Intervention;intervention refinement;Interview;Knowledge;Length;Life;Malignant neoplasm of testis;Malignant neoplasm of thyroid;Malignant Neoplasms;Melanoma;mHealth;mobile computing;model development;Names;neoplasm registry;Obesity;Participant;Patient-Focused Outcomes;Patients;Perception;Phase;pilot test;Plague;Population;population based;Positioning Attribute;Preparation;primary endpoint;process evaluation;psychosocial;Psychosocial Assessment and Care;Psychosocial Influences;psychosocial wellbeing;Quality of life;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;resilience;Resources;Schools;secondary endpoint;SEER Program;Self Efficacy;Self Management;Severity of illness;socioeconomics;Source;Specific qualifier value;support tools;Survivors;survivorship;System;Technology;Testing;therapy development;Thyroid Gland;Time;tool;trial planning;understudied cancer;United States;United States National Institutes of Health;uptake;usability;user centered design;Work;young adult

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-V (M1)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Prevention;Serious Mental Illness;Sleep Research;Suicide;Suicide Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE: In older adults, sleep-wake rhythm disruption and recurring depression/suicide ideation are often inter-related, unmet, clinical needs. This project will confirm the efficacy and mechanism-of- action of targeting sleep-wake rhythms with the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), specifically, to improve depression in adults 55+ years of age. This multi-site trial will confirm if and how this approach works, and for whom, thereby advancing evidence-based strategies for controlling depression symptoms in older adults who have depression and high suicide risk.

PI_NAMEs: SMAGULA, STEPHEN F (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: actigraphy;Active Listening;Acute;Adult;Aftercare;Age Years;Algorithms;anti-depressive agents;Behavioral;Blinded;Circadian Dysregulation;Clinic;Clinical;clinically significant;Data;Death Rate;depressive symptoms;Diagnostic;diaries;Dose;Double-Blind Method;efficacy outcomes;efficacy trial;Eligibility Determination;evidence base;experience;experimental study;Feeling suicidal;Friends;Future;Hamilton Rating Scale for Depression;Health;Heterogeneity;high risk;Hospitalization;Hour;ideation;Impairment;improved;improvement on sleep;Incidence;Individual;innovation;Intervention;Interview;Measures;Mediating;Mediation;Mediator;Medicine;Mental Depression;Mental Health;Methods;Monitor;Moods;multi-site trial;National Institute of Mental Health;older adult;Outcome;Participant;Patient Self-Report;Patients;Pattern;Pharmacotherapy;Phase;Population;post intervention;precision medicine;Precision therapeutics;Psychiatric therapeutic procedure;psychosocial;Randomized;Randomized, Controlled Trials;Recording of previous events;recurrent depression;reduce symptoms;reducing suicide;Research Personnel;response;Safety;Sampling;Science;secondary outcome;severe mental illness;Severities;Site;Sleep;Sleep Disorders;Sleep disturbances;sociodemographics;statistics;Strategic Planning;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Testing;Time;Training;treatment as usual;treatment effect;Treatment outcome;treatment response;trial comparing;United States;Work;Wrist

PROJECT_TITLE: Multi-site, double-blind, randomized-controlled, efficacy trial of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction for depression symptoms in older adults with high suicide risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (04)]


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Chronic intestinal inflammation is a critical risk factor for the development of colon cancer; however, molecular and cellular mechanisms underlying chronic intestinal inflammation are still being uncovered. The proposed research will allow us to validate the importance of gene related to anergy in lymphocyte (Grail) expression in mucosal T follicular helper cells and its role in regulating the balance between intestinal homeostasis and inflammation. The implication from this work is significant, since it will provide novel insights into the genetic link between inflammation and cancer and project Grail as a potential marker for diagnosis of intestinal inflammation.

PI_NAMEs: NURIEVA, ROZA INSAFETDINOVNA (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: Address;anergy;B-Lymphocytes;cancer immunotherapy;carcinogenesis;carcinogenicity;Cell Physiology;Cells;Chronic;Clinical;Colitis associated colorectal cancer;Colon;Colon Carcinoma;colon tumorigenesis;Colonic inflammation;Colonic Neoplasms;Colorectal Cancer;cytokine;Development;Diagnosis;Disease;early detection biomarkers;Equilibrium;Foundations;Future;Genes;Genetic;Growth;gut inflammation;Helper-Inducer T-Lymphocyte;Hematopoietic;IL17 gene;Immune;Inflammation;Inflammatory;Inflammatory Response;insight;intestinal homeostasis;Intestinal Neoplasms;intestinal tumorigenesis;Intestines;knockout gene;Knockout Mice;Link;Lymphocyte;Lymphocyte Function;Malignant Neoplasms;Methods;Molecular;mouse model;Mucosal Immune Responses;Mucous Membrane;Mus;neoplastic;novel;novel marker;Patients;Play;Reagent;Reporter;Research;response;Risk Factors;Role;Severities;Time;tumor;tumor growth;Tumor stage;tumorigenesis;tumorigenic;ubiquitin-protein ligase;Wild Type Mouse;Work

PROJECT_TITLE: Role of Grail in colon inflammation and tumorigenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-Z (M1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Electronic Nicotine Delivery Systems;Pediatric;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: LOUISVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Due to the dramatic rise in adolescent e-cigarette use, we face an urgent need to promote e-cigarette cessation among adolescents; unfortunately, although most adolescent e-cigarette users are interested in quitting and have made at least one quit attempt, no empirically validated e-cigarette cessation interventions are available. For such interventions, formative research is needed to develop (1) a motivation-based typology of adolescent e-cigarette users in order to identify the cognitive and behavioral intervention targets specific to each type of user and (2) an understanding of adolescent views to further inform intervention content (e.g., examples of type-specific cues and maladaptive cognitions) and ensure maximal acceptability, engagement, and efficacy of the resulting interventions. The data from this project will inform the creation of subsequent adolescent e-cigarette cessation interventions that are targeted to specific use motivations, developmentally appropriate, grounded in cognitive behavioral principles, and highly engaging and acceptable to users.

PI_NAMEs: HART, JOY L.;MCLEISH, ALISON C (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Address;Adolescent;alcohol tobacco and other drug use;Attention;behavior change;Behavior Therapy;Behavioral;Belief;Brain;Cardiovascular Diseases;Cigarette Smoker;Clinical Trials;Cognition;Cognitive;cognitive development;combustible cigarette;comparative efficacy;Cues;Data;Data Reporting;design;Development;e-cigarette cessation;Electronic cigarette;electronic cigarette use;electronic cigarette user;Ensure;Face;flexibility;Focus Groups;Future;Generations;Health;Heterogeneity;High Prevalence;High School Student;Individual;interest;Intervention;Knowledge;Language;Literature;Methods;Motivation;Nicotine;Nicotine Dependence;nicotine exposure;nicotine use;Patient Self-Report;Pattern;peer;Perception;Population Intervention;preference;Prevalence;Psychopathology;psychosocial;recruit;Reporting;Research;Research Personnel;Respiratory Disease;Risk;Sampling;smoking cessation;social;Students;theories;therapy development;Tobacco;tobacco control;tobacco products;Tobacco use;tool;Treatment Protocols;Typology;uptake;vaping;Youth

PROJECT_TITLE: A Motivation-Based Adolescent Vaping Typology to Inform Cessation Interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-6 (M2)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Lung;Patient Safety;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Acute respiratory distress syndrome (ARDS) is a common form of severe lung injury that occurred in 10% of pre- pandemic ICU admissions, results in mortality of 30-45%, and has become a leading cause of death from COVID- 19. This multicenter randomized controlled trial evaluates whether a novel ventilation strategy that individualizes support to minimize lung stress, compared to guided usual care, improves survival and pulmonary recovery in ventilator-dependent patients with ARDS. Results from this trial may establish a personalized approach to ARDS management that reduces morbidity and mortality and, by extension, decreases costs and strain on the healthcare system.

PI_NAMEs: BEITLER, JEREMY R.;TALMOR, DANIEL STUART (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: abdominal pressure;Acute;Acute Respiratory Distress Syndrome;Adipose tissue;Admission activity;Adult;Alveolar;Anatomy;arm;Atelectasis;atelectrauma;Attenuated;Automobile Driving;Blinded;Body Weight;Breathing;Cause of Death;Chest wall structure;circulating biomarkers;Clinical;Clinical Management;Cognitive;Cohort Studies;cost;COVID-19;COVID-19 mortality;COVID-19 pandemic;Edema;Esophagus;Etiology;experience;expiration;Fibrosis;Grant;Healthcare Systems;hemodynamics;Heterogeneity;Histologic;Hospitalization;Human;Hypoxemia;improved;Injury;Insufflation;Intensive Care;Intra-abdominal;Life;Lung;lung injury;lung volume;Manometry;Measures;Mechanical Stress;Mechanical ventilation;Mechanics;Modeling;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;National Heart, Lung, and Blood Institute;Normal Range;novel;Outcome;Pancreatitis;Patient-Focused Outcomes;Patients;Periodicity;personalized approach;personalized strategies;Phase;physical impairment;Pleural;Pleural effusion disorder;Pneumonia;Positioning Attribute;Positive-Pressure Respiration;pre-clinical;Pre-Clinical Model;pre-pandemic;Predisposition;pressure;prevent;psychologic;Public Health;Pulmonary Edema;randomized trial;Randomized, Controlled Trials;receptor for advanced glycation endproducts;Recovery;recruit;Relaxation;Research;Risk;Role;Safety;Sepsis;Shapes;Shock;soft tissue;standard care;standard of care;Stress;stress reduction;Structure of parenchyma of lung;surfactant;Survivors;systemic inflammatory response;Testing;Tidal Volume;Time;Titrations;Trauma;treatment as usual;usual care arm;ventilation;Ventilator;Ventilator-induced lung injury;volunteer

PROJECT_TITLE: 1/2: PREcision VENTilation to attenuate Ventilation-Induced Lung Injury (PREVENT VILI)

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cervical Cancer;Clinical Research;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

PHR: PROJECT NARRATIVE There is an urgent need to develop low-cost, accurate and accessible approaches to improve cervical cancer screening in low- and middle-income countries, which bear the greatest burden of disease. We will adapt advances in nucleic acid amplification technology developed for COVID surveillance to develop the NATFlow HPV assay, a low-cost, fully integrated, sample-to-answer nucleic acid test that meets the needs for cervical cancer screening in low-resource settings. We will use a community- and stakeholder-engaged process to evaluate the technical and clinical performance of the NATFlow HPV test in Mozambique, as well as barriers and facilitators to its future implementation, in Mozambique.

PI_NAMEs: LORENZONI, CESALTINA FERREIRA;MONTEALEGRE, JANE R;RICHARDS-KORTUM, REBECCA R. (contact)

PROGRAM_OFFICER_NAME: SAHASRABUDDHE, VIKRANT V

PROJECT_TERMS: Acceleration;Acetic Acids;Address;Adoption;Africa South of the Sahara;Age;amplification detection;Australia;Biological Assay;burden of illness;Cancer Etiology;carcinogenicity;Caring;Cell Line;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cessation of life;Chemistry;Clinical;commercialization;Communities;community clinic;community partners;contextual factors;cost;Country;COVID-19 assay;COVID-19 surveillance;Cytology;Death Rate;design;Detection;detection limit;detection platform;Devices;Diagnosis;Disease;Disparity;DNA;DNA amplification;Early Diagnosis;Early treatment;Eligibility Determination;Enrollment;Equipment;experience;Female;future implementation;General Population;girls;Goals;Health;high risk;HIV;Hospitals;Hour;HPV screening;HPV-High Risk;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;Human Resources;Immunization Programs;implementation research;Improve Access;improved;Incidence;Income;Industrialization;Infrastructure;innovation;instrument;instrumentation;isothermal amplification;Lateral;lateral flow assay;Lesion;low and middle-income countries;low income country;Malignant neoplasm of cervix uteri;Malignant Neoplasms;manufacture;Mediating;medical specialties;Methods;mortality;Mozambique;New England;new technology;novel;Nucleic Acid Amplification Tests;nucleic acid detection;Nucleic Acids;Organizational Objectives;Performance;performance tests;point of care;point of care testing;premalignant;Preparation;preservation;prevent;Process;programs;prospective;Provider;Qualifying;Recommendation;Reporting;Resource-limited setting;Rice;Risk;Sampling;screening;Sensitivity and Specificity;Specimen;Technology;Temperature;Testing;Time;tool;Training;Training and Infrastructure;Translating;Translational Research;usability;Vaccination;Visual;Woman;women's diagnosis;Work;World Health Organization

PROJECT_TITLE: Sample-to-answer HPV DNA nucleic acid test for cervical cancer screening in Mozambique

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-Q (M1)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome

ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Antibiotic resistant bacteria are a growing global threat to human health and wellbeing. I propose to investigate how the spatiotemporal organization and physiology of gut bacteria could be targeted to stop the emergence and spread of antibiotic resistance. This work will inform the design of new strategies for combating antibiotic resistance through the therapeutic manipulation of the intestinal microbiome’s physical architecture.

PI_NAMEs: WILES, TRAVIS J (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Affect;Agriculture;Animals;Antibiotic Resistance;Antibiotics;Architecture;Attention;Bacteria;Bacterial Antibiotic Resistance;bacterial community;bacterial resistance;Bacteriophages;Behavior;Biological Models;Cell Physiology;Cells;Ciprofloxacin;Collection;Combating Antibiotic Resistant Bacteria;Complex;de novo mutation;design;Disease;Dissociation;DNA Damage;Dose;drug development;Ecology;Ecosystem;Elements;Environment;Environmental Risk Factor;Evolution;experimental study;fighting;Food Supply;Future;Genetic;Genetic Engineering;genetic manipulation;gut bacteria;gut microbiome;Health;Horizontal Gene Transfer;Human;Image;In Situ;In Vitro;Individual;Infection;innovation;Intestines;Livestock;Memory;Methods;Microbe;microbial;microbiota;Mobile Genetic Elements;Modeling;Molecular;molecular scale;Motility;Motivation;Movement;Mus;Mutation;Nature;novel;Optics;pathogen;Pathway interactions;Personal Satisfaction;Pharmaceutical Preparations;Physical shape;Physiological;Physiology;Plasmids;preservation;prevent;Production;public health intervention;Reporter;Research;Resistance;resistance gene;Resolution;response;side effect;Signal Pathway;SOS Response;spatiotemporal;Structure;Swimming;synthetic biology;System;Testing;Therapeutic;Time;Tissues;tool;trait;transmission process;Work;Zebrafish

PROJECT_TITLE: Connecting the Spatiotemporal Organization of Gut Bacterial Communities to the Emergence and Spread of Antibiotic Resistance


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Bacterial toxins that target insects could be utilized for developing bio-pesticides to control harmful insects, but a molecular understanding of toxin-host interactions is required. Here, we seek to establish and validate new methods and tools for carrying out unbiased genome-wide screens on insect cell models to uncover key host factors mediating the action of insect- targeting bacterial toxins.

PI_NAMEs: DONG, MIN  (contact);PERRIMON, NORBERT

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Bacterial Toxins;Bacteriophages;Cell Line;Cell model;Cells;Communicable Diseases;Communities;CRISPR screen;CRISPR/Cas technology;Culicidae;Dengue;design;Development;Drosophila genus;Drosophila melanogaster;experimental study;Family;Family member;fly;Future;Genetic Recombination;genome wide screen;genome-wide;Goals;Guide RNA;Human;human disease;human pathogen;In Vitro;in vivo;Insecta;Insecticides;Integration Host Factors;knock-down;Knock-out;Knowledge;lentivirally transduced;Lentivirus;Libraries;Life Cycle Stages;Lyme Disease;Malaria;Mammalian Cell;Mediating;member;Methods;Modeling;Molecular;mosquitocidal;Mucins;Nematoda;novel;pathogen;Pathogenesis;pathogenic bacteria;Plasmids;Proteins;prototype;receptor;recombinase-mediated cassette exchange;RNA library;Role;Series;Site;Small Interfering RNA;Specificity;success;System;Targeted Toxins;Technology;tool;Toxic effect;Toxin;transmission process;Validation;vector;Virulence Factors;West Nile;Xenorhabdus luminescens;ZIKV disease

PROJECT_TITLE: Genome-wide CRISPR-Cas9 screens in insect cells to characterize insecticidal toxins

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLLEGE STATION

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: NARRATIVE Building on social network and mentoring co-regulation theories, we propose to develop a generalizable model of how peer and mentor social networks can be leveraged to promote diverse students’ access to social capital and support for self-regulated learning skills, which in turn facilitate biomedical research career success. We propose to use a longitudinal experimental design to compare short-, medium-, and long-term “Hallmarks of Success” (e.g., well-being, degree conferral) of diverse first-year biomedical engineering students. Participating students will be assigned to one-of-three peer-network intervention groups and one-of-two mentor-network intervention groups, and the differential intervention effects for students from historically over- and under- represented racial/ethnic groups will be assessed.

PI_NAMEs: ALGE, DANIEL ;HERNANDEZ, PAUL R (contact);PATTERSON, MEGAN STIEFEL

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Address;Award;Bachelor's Degree;Biomedical Engineering;Biomedical Research;Birds;Black race;career;cohort;Communities;Control Groups;Data;Development;disadvantaged background;Disparity;Drops;Educational workshop;Engineering;Ensure;ethnic minority;ethnic minority population;Ethnic Population;experience;Experimental Designs;experimental study;Feathers;follow-up;Generations;Geoscience;Goals;graduate student;group intervention;Growth;help-seeking behavior;Hispanic;Hispanic-serving Institution;improved;Individual;Intervention;intervention effect;Latinx;Learning;Learning Skill;learning strategy;Link;Literature;Measures;Mediating;Medicine;Mentors;Mentorship;Methods;model generalizability;Network-based;Not Hispanic or Latino;Outcome;Participant;peer;peer coaching;Peer Group;peer networks;Personal Satisfaction;Positioning Attribute;Postdoctoral Fellow;Process;psychosocial;racial minority;racial minority population;racial population;Randomized;recruit;Research;Research Personnel;Resources;Sampling;self-directed learning;social capital;Social Network;social network intervention;Social support;statistics;student participation;Students;success;Testing;Texas;theories;therapy design;Time;Training;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: Biomedical Engineering Social Networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-W (RI)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: The results of this mechanistic study will provide first evidence for a role of vesicular acetylcholine transporter in the pathophysiology of depression and as the mechanism of action of a novel cholinergic intervention. Our findings will thus provide the first in vivo human support of the cholinergic hypothesis of depression, and the proof of concept to support a larger investigation of this novel biological avenue for treatment.

PI_NAMEs: DELORENZO, CHRISTINE ;PARSEY, RAMIN V. (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Acetylcholine;acetylcholine transporter;Acute;Affect;Aftercare;Age;Animal Model;Animals;anti-depressive agents;antidepressant effect;Automobile Driving;Biological;Biological Process;Brain;cholinergic;Chronic;common treatment;Data;density;Depressed mood;depression model;depressive symptoms;design;Development;Diagnosis;disability;Disease remission;Exhibits;experimental study;Functional disorder;Future;healthy volunteer;high reward;high risk;Hippocampus;Human;imaging study;in vivo;Individual;insight;interest;Intervention;Investigation;Literature;Major Depressive Disorder;Measures;Mental Depression;mRNA Expression;Neurobiology;neuropsychiatric disorder;Neurotransmitters;Nicotine;novel;novel drug class;novel therapeutic intervention;Outcome;Participant;Pathology;Persons;Pharmacotherapy;Positron-Emission Tomography;Publishing;restraint stress;Rodent;Role;Selective Serotonin Reuptake Inhibitor;Severities;sex;Signal Transduction;Symptoms;Synaptic Vesicles;System;targeted treatment;Therapeutic;therapeutic development;Time;Tracer;Validation;Visualization;World Health Organization

PROJECT_TITLE: Preliminary imaging studies evaluating the vesicular acetylcholine transporter as a treatment target in major depressive disorder

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Menopause increases the risks of various diseases like cardiovascular disorders, osteoporosis, depression, and cognitive decline, however current clinical markers are not able to identify when the menopause transition will start nor how long it will last. While identifying menopause transition biomarkers is challenging due to the complex multi-cellular, spatial and temporal heterogeneity of the ovary, systems approaches are ideal frameworks to integrate spatiotemporal multi-omics assessments (e.g., single-cell and spatial transcriptomics, and non-targeted metabolomics) in order to reveal the key signaling and metabolic processes that regulate a phenotype, i.e., menopause transition. Here we prosed to use a Systems Metabolic network-based approach, Genome-scale metabolic models (GMMs), to identify age-regulated ovarian-produced metabolites that can be secreted into circulation and are significantly associated with and predictive of the state of the menopause transition potentially enabling interventions to delay early or premature menopause, and reduce the risk of future menopause-related diseases.

PI_NAMEs: PENALVER BERNABE, BEATRIZ  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: Address;Age;age related;Age Years;Aging;Area;Biochemical Pathway;biological age;Biological Assay;Biological Markers;Biological Process;biomarker identification;Brain;Cardiovascular Diseases;cardiovascular disorder risk;Cell model;cell type;Cells;Circulation;Clinical;clinical diagnostics;Clinical Markers;cognitive function;Communication;Communities;Complex;Consumption;Cortex of ovary;daily functioning;Data;Data Set;Development;diagnostic tool;Disease;Early Intervention;Endothelial Cells;Epithelial Cells;Estrogens;Exclusion;Female;Fertilization;Follicle Stimulating Hormone;Foundations;Future;Genetic Transcription;genome-wide;Germ Cells;Glucose;Goals;health related quality of life;Heterogeneity;Hot flushes;Immune;Impaired cognition;Individual;Intervention;Knowledge;Length;life span;Location;Measurable;Measures;Menopausal Symptom;Menopause;Menstruation;Mental Depression;Metabolic;Metabolic Marker;Metabolism;metabolomics;Migraine;migration;minimally invasive;Modeling;Mood Disorders;mullerian-inhibiting hormone;Multiomic Data;multiple omics;Mus;network models;Network-based;novel;novel marker;old mice;Oocytes;Organ;Organism;Osteoporosis;Ovarian;Ovarian aging;Ovarian Follicle;ovarian reserve;Ovary;Perimenopause;personalized intervention;Phenotype;Premature Menopause;prepuberty;preventive intervention;primary ovarian insufficiency;Process;prospective;Proteomics;Quality of life;Reaction;reduce symptoms;Reproduction;reproductive;Research;Risk;Risk Reduction;Role;Sensitivity and Specificity;Serum;Signal Transduction;single-cell RNA sequencing;Sleep Disorders;Sleep disturbances;Somatic Cell;spatiotemporal;Steroid biosynthesis;success;Symptoms;System;Testing;tool;transcriptomics;Validation

PROJECT_TITLE: Utilizing spatially-informed cell-specific multicellular genome-scale metabolic models to unveil the mechanisms that regulate the decline of the ovarian reserve

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Although antiretroviral therapy (ART) is now widely available, people with HIV continue to have shorter life expectancy compared to the general population. We previously found that gut barrier dysfunction predicted mortality in persons with ART-suppressed HIV and a history of AIDS. Cytomegalovirus (CMV), a common coinfection in HIV, disrupts the gut barrier, and a recent clinical trial showed that a drug active against CMV reduced harmful immune activation in HIV-infected participants. In this project, we will study the role of CMV in gut barrier dysfunction and immune activation. We predict that treatment for CMV infection will help restore gut barrier function and improve outcomes for HIV-infected individuals on ART.

PI_NAMEs: HUNT, PETER W;SHACKLETT, BARBARA L. (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS clinical trial group;Ancillary Study;Antigen Presentation;antigen-specific T cells;antiretroviral therapy;base;Biological Markers;CD8-Positive T-Lymphocytes;Cells;Chronic;Clinical Trials;co-infection;cohort;Colorectal;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Defect;Dendritic Cells;Disease;DNA;Epitopes;exhaustion;Failure;Functional disorder;Funding;gastrointestinal;gastrointestinal epithelium;Gastrointestinal tract structure;General Population;Gut Mucosa;HIV;HIV Infections;Homing;immune activation;Immune System Diseases;imprint;improved;improved outcome;in vivo;Individual;Infection;intestinal barrier;Life Expectancy;Macaca mulatta;Measures;Mediating;microbial;Modeling;Modified Vaccinia Virus Ankara;mortality;Mucous Membrane;Parents;Participant;Pathogenesis;Pathway interactions;peripheral blood;Persons;Pharmaceutical Preparations;Plasma;Prediction of Response to Therapy;Recording of previous events;response;Role;senescence;Series;Site;Specificity;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Tight Junctions;Tissues;trafficking;Tretinoin;United States National Institutes of Health;Vaccination;vaccination strategy;vaccine strategy;Vaccine Therapy;Vaccines;vector vaccine

PROJECT_TITLE: Cytomegalovirus (CMV), the gut barrier and immune dysfunction in HIV


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Drug Abuse (NIDA only);Immunization;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse;Women's Health Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

PHR: NARRATIVE Pre-pregnancy obesity is associated with significant adverse health outcomes for the mother including increased risk of gestational diabetes and hypertension, preeclampsia and infection. Recent studies from our laboratory revealed significant changes in immune cell function in blood samples collected from obese women at week 37 of gestation. Since immune cells play a critical role in anti-microbial defense as well as the development of chronic inflammation, this application will carry out an in-depth investigation of maternal pre-pregnancy obesity- driven changes in the functional, transcriptional, and epigenetic landscape of blood immune cells.

PI_NAMEs: MESSAOUDI, ILHEM  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 37 weeks gestation;Address;adverse outcome;adverse pregnancy outcome;age related;antimicrobial;Biology;Birth;Blood;Blood specimen;Body mass index;Categories;Cell Physiology;cell type;Cells;Cesarean section;Chronic;comorbidity;Data;Decidua;Dendritic Cells;Development;Dimensions;epidemiology study;Epigenetic Process;epigenome;Equilibrium;Exhibits;experimental study;Female of child bearing age;fetal;Fetal Growth;Frequencies;Functional disorder;Genetic Transcription;Genomics;Gestational Age;Gestational Diabetes;Gravid;Growth;Growth and Development function;Health;healthy pregnancy;Heterogeneity;Homeostasis;Host Defense;Immune;Immune system;Immunologics;Immunology;Impaired wound healing;Impairment;Induced Labor;Infection;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Innate Immune System;insight;intraamniotic infection;Investigation;Labor Complications;Laboratories;Ligands;Link;Macrophage;Macrophage Activation;Maintenance;maternal outcome;Maternal-Fetal Exchange;Maternal-fetal medicine;Maternally-Acquired Immunity;Metabolic;Metabolism;Modeling;Molecular;monocyte;Natural Killer Cells;next generation sequencing;novel;obese mothers;Obesity;Outcome;peripheral blood;Phagocytes;Phenotype;Placenta;Placentation;Play;Positioning Attribute;Pre-Eclampsia;Predisposition;Pregnancy;pregnancy hypertension;Pregnant Women;Premature Birth;prepregnancy obesity;Publishing;recruit;response;Risk;Role;Sampling;Statistical Models;surgical risk;Surgical Wound Infection;Systems Biology;Testing;Thinness;Third Pregnancy Trimester;Time;Tissues;Villous;Woman;wound healing

PROJECT_TITLE: Dysregulation of maternal immunity during pregnancy by pregravid obesity


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Pinpointing the putative susceptibility genes that mediate genetic associations in breast cancer has been a challenge, partly due to lack of data on alternative transcript-isoforms and splice sites in available gene expression datasets. We will enhance existing large short-read RNA-sequencing datasets by quantifying isoform and alternative splicing patterns, leveraging tissue-specific long-read RNA-seq datasets as reference. We will build on our previous experience developing cutting-edge machine learning frameworks to not only elucidate breast cancer risk etiology, but also provide open-source computational pipelines and data resources for future research by the human genetics community.

PI_NAMEs: BHATTACHARYA, ARJUN  (contact);LINDSTROEM, SARA

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: Address;Alternative Splicing;Atlases;Automobile Driving;Benchmarking;Biological;Biological Process;Breast;Breast Cancer Risk Factor;breast tumorigenesis;cancer diagnosis;cancer genomics;cancer risk;candidate identification;Cell Line;Chromosome Mapping;Code;Communities;Complex;computational pipelines;computer framework;computerized tools;Computing Methodologies;Consensus;cost;Data;data resource;Data Set;Development;Etiology;Evaluation Studies;Event;Excision;experience;follow-up;functional genomics;Gene Expression;Gene Rearrangement;Genes;Genetic;genetic architecture;genetic association;genetic predictors;Genetic Predisposition to Disease;Genetic study;genetic variant;genome wide association study;genomic data;genomic epidemiology;genomic locus;Genomic Segment;Genotype;Genotype-Tissue Expression Project;Germ Lines;Heritability;Human;Human Genetics;innovation;insight;Introns;Investigation;Investments;Libraries;machine learning framework;machine learning method;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammographic Density;Maps;Measurement;Mediating;Mediator;Messenger RNA;Methods;Modeling;Molecular;neoplastic cell;neuropsychiatric disorder;novel;open source;Outcome;Pathway interactions;Pattern;Phenotype;predictive modeling;promoter;Protein Isoforms;Quantitative Trait Loci;Reproducibility;Research;Resources;response;Risk;RNA Splicing;secondary analysis;Sequence Alignment;Site;Spliced Genes;statistics;Susceptibility Gene;The Cancer Genome Atlas;Tissue Model;Tissues;trait;Transcript;transcriptome;transcriptome sequencing;transcriptomics;translational potential;Tumor Tissue;Untranslated RNA;Variant;Work

PROJECT_TITLE: Alternative splicing and isoform expression as mediators for the genetic etiology of breast cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Hypertension;Nutrition;Physical Activity;Prevention;Rehabilitation

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE  Combining a modified dietary approaches to stop hypertension (modDASH) eating plan with a home-based exercise program may be a new method that people with peripheral artery disease can do to optimally improve walking ability, quality of life, vascular function, and vascular inflammation. These improvements could also improve the long-term risks of having major cardiovascular events, as well as improve other health conditions such as obesity, diabetes, high cholesterol, and high blood pressure.

PI_NAMEs: GARDNER, ANDREW W (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Affect;Age Years;American;Ankle;Behavioral Paradigm;Biological Markers;Blood flow;Blood Vessels;C-reactive protein;cardiovascular risk factor;Cardiovascular system;Cholesterol;claudication;Clinical;clinically relevant;clinically significant;comparative effectiveness;Comparative Effectiveness Research;Consumption;cost;DASH diet;Data;Death Rate;Diabetes Mellitus;dietary;Dietary Intervention;Eating;efficacy testing;Event;Exercise;exercise intervention;exercise program;Exercise Therapy;fruits and vegetables;Functional disorder;Goals;Health;health related quality of life;Hemoglobin;High Prevalence;Home;human old age (65+);Hypertension;Impairment;improved;indexing;Inflammation;innovation;Institute of Medicine (U.S.);Intervention;Investigation;Knowledge;Leg;Lower Extremity;Measures;Mediating;Metabolic syndrome;Methods;Monitor;Muscle;novel;Obesity;Outcome;Outcome Measure;Pain in lower limb;patient oriented;Patients;Peripheral;Peripheral arterial disease;Persons;Physical Function;Physiological;primary outcome;programs;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Risk;Risk Factors;secondary outcome;Severities;standard care;standard of care;Symptoms;systemic inflammatory response;Testing;Therapeutic Intervention;Time;treatment strategy;Unhealthy Diet;vascular inflammation;Walking;Work

PROJECT_TITLE: The Effects of Diet and Exercise Interventions in Peripheral Artery Disease

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Behavioral and Social Science;Clinical Research;Disability Research;Lupus;Prevention;Rehabilitation

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Functional impairment, or reduced ability to carry out day-to-day tasks, is often associated with older populations but may occur in lupus patients of all ages. Our study aims to: estimate the burden of both physical and cognitive functional impairment; identify potential risk factors for this impairment among lupus patients; and compare outcomes among lupus patients with and without signs of impairment. The results of this study will help adapt and target geriatric interventions to support lupus patients with impairment, which will be essential for the maintenance of high-quality, patient-centered, efficient clinical care of the rapidly aging U.S. lupus population.

PI_NAMEs: PLANTINGA, LAURA  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Affect;Age;age group;age related;aged;Aging;aging population;Ancillary Study;care costs;Caring;Characteristics;Chronic Disease;Clinical;clinical care;Cognitive;cognitive function;cognitive performance;cohort;Communities;Complex;cost;Data;Disability status;Disease;Elderly;End stage renal failure;experience;falls;Functional disorder;Functional impairment;Goals;Health;High Prevalence;Hospitalization;Immunity;Impaired cognition;Impairment;Inflammation;inflammatory marker;instrument;Intervention;Life Expectancy;Link;Lupus;Maintenance;Measurement;Measures;men;Mental Depression;middle age;Morbidity - disease rate;mortality;Neurobehavioral Manifestations;novel;older patient;Older Population;Organ;Outcome;overtreatment;patient oriented;patient population;Patient risk;Patient Self-Report;Patients;Pattern;Persons;Physical assessment;Physical Function;physical impairment;Physical Performance;Pilot Projects;Population;population based;potential biomarker;Prevalence;Prevention;Preventive;Quality of life;Rare Diseases;Reporting;Resources;Risk;Risk Factors;Risk Reduction;risk stratification;Sampling;sociodemographics;Stress;Supportive care;Systemic Lupus Erythematosus;Target Populations;Treatment Cost;Woman;Work;young woman

PROJECT_TITLE: Burden, correlates, and outcomes of poor cognitive and physical functioning in the lupus population

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: CINCINNATI

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Impairments in walking and balance are common after stroke, and current rehabilitation strategies lack specificity due to a limited mechanistic understanding of the early determinants of walking and balance recovery. This study will serially track the development of balance control, walking ability, and fall events in the first six months following a stroke, and use structural imaging to identify key neurological correlates. Knowledge gained from this study will likely improve the precision of rehabilitation by leading to more informed and customized treatment strategies.

PI_NAMEs: AWOSIKA, OLUWOLE OLADIMEJI (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Academy;Acute;American;Anatomy;Anisotropy;Assessment tool;balance recovery;Biological;Biomechanics;Biometry;career development;Caregivers;Cessation of life;Characteristics;Chronic;Chronic Phase;Clinical;Clinical Investigator;clinical trial recruitment;Collaborations;Cross-Sectional Studies;Dependence;design;Development;Diffusion Magnetic Resonance Imaging;Disease;Early identification;equilibration disorder;Equilibrium;Event;Evolution;expectation;fall risk;falls;fear of falling;Fostering;Fracture;Functional disorder;Future;Gait abnormality;Goals;Health;Hospitals;Human;Impairment;improved;Incidence;indexing;Individual;individualized medicine;Injury;innovation;insight;Intervention;Journals;Knowledge;Lead;Light;Magnetic Resonance Imaging;Measures;medical complication;meter;Methodology;Motor;motor control;Motor Pathways;multimodal neuroimaging;Musculoskeletal Equilibrium;Neuroanatomy;Neurologic;neurological rehabilitation;Neurology;neuroregulation;Outcome;Participant;Physiological;post stroke;Posture;Process;Protocols documentation;Public Health;Recovery;recruit;rehabilitation strategy;Rehabilitation therapy;Research;research clinical testing;Research Personnel;Research Proposals;Resolution;response;Sensory;sensory input;sensory system;Shapes;Social isolation;somatosensory;spatiotemporal;Specificity;Stroke;stroke survivor;structural imaging;Supratentorial;Survivors;Technology;Testing;Time;tractography;treatment strategy;trial design;United States;vestibular system;Visual;Walking;walking performance;walking rehabilitation;walking speed

PROJECT_TITLE: Tracking the Development and Influence of Post-Stroke Sensory Reweighting on Walking and Balance Outcomes

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE: Toxoplasma is an important opportunistic pathogen of humans and has infected over a billion people worldwide, where it can cause severe disease in HIV/AIDS patients, the developing fetus and other susceptible children and adults. Our goal is to use comparative approaches to determine how this parasite causes disease.

PI_NAMEs: BOYLE, JON P (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Acute;Adopted;Adult;Animal Model;Animals;Antiparasitic Agents;Automobile Driving;Biology;Candidate Disease Gene;Cell Aging;Cell Cycle;Cells;Child;comparative;comparative genomics;Complement;Cyst;Data;Development;Developmental Gene;Disease;DNA Damage;epigenomics;experience;experimental study;Fetal Development;follow-up;Foundations;functional genomics;Funding;Gene Expression Regulation;Genes;Genetic;genetic approach;Goals;Growth;Growth and Development function;HIV/AIDS;Host Defense;human disease;human pathogen;Immune response;Immunosuppression;in vitro Assay;Infection;Inflammatory;Inflammatory Response;Innate Immune Response;innovation;knockout gene;Life Cycle Stages;Link;Masks;Modeling;Molecular;new therapeutic target;novel;novel therapeutic intervention;nucleic acid binding protein;obligate intracellular parasite;opportunistic pathogen;Organism;Outcome;Parasites;Pathogenesis;Pathway interactions;Patients;Persons;Phenotype;Placenta;Predisposition;prevent;Refractory;Regulation;Regulatory Pathway;response;Signal Pathway;Sporozoites;Stress;success;Synteny;System;Testing;Therapeutic Intervention;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;trait;transcriptome sequencing;transcriptomics;Transgenic Organisms;Virulence;Virulence Factors;virulence gene;Work

PROJECT_TITLE: Comparative and functional genomics of Toxoplasma and Hammondia hammondi

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease;Nutrition

ORG_CITY: Boulder

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Vascular dysfunction contributes to a higher risk of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) in comparison to individuals without CKD. This study will assess how daily consumption of beetroot juice changes factors in circulation (blood) to improve vascular function in patients with CKD. Overall, this research will provide scientific evidence supporting the use of beetroot juice for improving vascular function in CKD and insight into the biological reasons (mechanisms) by which this occurs.

PI_NAMEs: ROSSMAN, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acetylcholine;active method;Age Years;Antioxidants;Aorta;Attenuated;Biological;Biological Availability;Biomedical Research;Blood;Blood Vessels;brachial artery;Cardiovascular Diseases;cardiovascular disorder risk;Cause of Death;Cell Culture Techniques;Cell Physiology;Chronic;Chronic Kidney Failure;Circulation;Clinical Trials;commensal bacteria;Consumption;dietary nitrate;Double-Blind Method;effective therapy;efficacy evaluation;Endothelial Cells;endothelial dysfunction;Endothelium;Exposure to;fitness;Glomerular Filtration Rate;Health;high risk;Human;improved;Individual;Ingestion;innovation;insight;Intervention;Juice;Mediating;men;Mentored Research Scientist Development Award;metabolome;metabolomics;Mitochondria;Molecular;Nitrates;Nitric Oxide;Nitric Oxide Pathway;Nitrite Reductase;Nitrites;novel;novel strategies;novel therapeutics;older adult;Oral cavity;Oxidative Stress;Pathway interactions;Patients;Phase II Clinical Trials;Placebos;Plasma;primary outcome;Production;Randomized;randomized, clinical trials;Reactive Oxygen Species;Research;Research Priority;Role;Sampling;Signal Pathway;Sodium Nitrite;Source;Supplementation;Testing;Transducers;Translating;translational approach;Vascular Diseases;vascular endothelial dysfunction;Vascular Endothelium;Woman

PROJECT_TITLE: Circulating factors as a mechanism of improvements in vascular endothelial function with inorganic nitrate in patients with chronic kidney disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Object recognition lies at the heart of our ability to make sense of the visual world, engaging a series of hierarchical processing in the ventral temporal cortex (VTC) and medial temporal lobe (MTL) network, which coordinately transforms the visual inputs to semantic representation. This project aims to reveal the underlying neural computations and circuit-level dynamics during this process using human intracranial recordings at both single-neuron and neural-circuit levels, behavioral measurements, and sophisticated computational algorithms. The anticipated outcomes of this proposal will contribute to the mechanistic understanding of object perception, which will shed light on developing new therapeutic interventions for patients affected by object recognition difficulties .

PI_NAMEs: CAO, RUNNAN  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Achievement;Address;Affect;Alzheimer's Disease;analysis pipeline;Area;artificial neural network;Award;behavior measurement;Behavioral;Brain;career;career development;Categories;Cells;Code;cognitive neuroscience;Computational algorithm;Computer Models;Coupled;Coupling;Data;Dementia;discrimination task;Disease;Electrodes;Electroencephalography;Emotions;Ensure;Etiology;examination questions;Exhibits;Face;Frequencies;Goals;Hallucinations;Heart;Human;Image;Impairment;Individual;insight;Label;Laboratories;Literature;medial temporal lobe;Memory;Mentors;Microscopic;Modeling;Monkeys;Nervous System Disorder;neural;neural circuit;neural model;neural network;Neural Pathways;neuroimaging;Neurologic;neuromechanism;neuronal circuitry;Neurons;neurotransmission;nonhuman primate;novel;novel therapeutic intervention;object perception;object recognition;Outcome;Pathway interactions;Patients;Performance;Persons;Phase;Primates;Process;Research;response;Scheme;Schizophrenia;Semantics;Series;Shapes;social cognition;statistics;Stimulus;success;Surveys;Syndrome;Temporal Lobe;Testing;Texture;Training;Translating;Universities;Visual;Visual Agnosias;visual cognition;Visual Cortex;visual information;Visual Pathways;Washington;Work

PROJECT_TITLE: Delineating the neural computational network for object recognition

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (03)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Tuberculosis

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Patients with tuberculosis (TB) can benefit greatly if we could identify signs of poor response earlier and adjust therapy intensity accordingly. Innovations in DNA isolation and sequencing technologies now enable the study of TB pathogen populations in an individual patient with very high resolution. Here, we propose to use these technologies and a highly well-characterized cohort of South African TB patients to investigate how pathogen population genetic changes link to pathogen survival and treatment response, laying the foundation for improvements in clinical treatment monitoring using DNA sequencing.

PI_NAMEs: FARHAT, MAHA  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Adherence;Adopted;Affect;Aftercare;Alcohol abuse;Alcohol consumption;Anabolism;Antibiotic Therapy;Antibiotics;arms race;Attenuated;Bacteria;Biohazardous Substance;Bioinformatics;Biological;Biological Response Modifiers;Clinical;clinical predictors;Clinical Treatment;Cobalamin;cohort;Communicable Diseases;Complex;Data;Data Set;Development;Diagnosis;DNA;DNA sequencing;Drug Kinetics;Drug resistance;Drug Tolerance;Early identification;Early Intervention;Evaluation;Evolution;experience;Failure;Family;Foundations;Gene Frequency;Genes;Genetic;Genetic Recombination;genetic variant;Genetic Variation;Genome;genome sequencing;Genomic approach;genomic variation;Genomics;Genotype;Geography;Growth;Heritability;high risk;HIV;Human;Immune;Immune response;Immune system;Immunocompetence;immunological status;Immunotherapeutic agent;improved;improved outcome;in silico;Individual;individual patient;Infection;innovation;Integration Host Factors;Intervention;Iron;Isoniazid resistance;Knowledge;Link;Machine Learning;Measurable;medication compliance;Metabolic;Methodology;Methods;Minimum Inhibitory Concentration measurement;Minor;Modeling;Molecular;Monitor;Mutation;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;novel;Outcome;pathogen;pathogen genomics;Pathway interactions;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Phenotype;Population;Population Genetics;Population Heterogeneity;Prediction of Response to Therapy;predictive modeling;Predisposition;pressure;prevent;prospective;real time monitoring;recruit;Recurrent disease;Regulator Genes;Relapse;relapse risk;Resistance;Resistance development;resistance gene;resistant strain;Resolution;response;Rifampin;Role;Sampling;Source;South Africa;South African;Specific qualifier value;Specimen;Speed;Sputum;statistical learning;Sterilization;Technology;Test Result;Testing;Time;Training;Treatment Failure;Treatment outcome;Treatment Protocols;treatment response;Tuberculosis;tuberculosis treatment;Variant;Virulent;whole genome;Work

PROJECT_TITLE: Investigating bacterial contributions to TB treatment response: a focus on in-host pathogen dynamics

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Adolescence is a period of remarkable psychological, social, and physiological changes and a pivotal transition for youth with autism spectrum disorder (ASD), a condition characterized by difficulty with social competence and change including developmental transitions. The overarching goal is to focus on mental health and key developmental, physiological, socioemotional, and demographic factors that confer risk or resiliency in youth with ASD or TD.

PI_NAMEs: CORBETT, BLYTHE ANNE (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 14 year old;Acceleration;Address;Adolescence;Adolescent;adolescent with autism spectrum disorder;Adult;Age;age effect;Area;Arousal;autism spectrum disorder;autistic;biobehavior;biopsychosocial;Central Nervous System;Clinical;cognitive process;cohort;Communication;Complex;coping;Coping Skills;critical period;Data;Demographic Factors;depressive symptoms;Development;Diagnosis;early adolescence;Elderly;Emotional;emotional factor;emotional functioning;Emotions;Enrollment;Event-Related Potentials;Female;Foundations;Gender;Goals;Health Status;heart rate variability;high risk;Hormones;Hydrocortisone;hypothalamic-pituitary-adrenal axis;indexing;Individual;innovation;Knowledge;longitudinal design;Longitudinal Studies;male;Mental Depression;mental development;Mental disorders;Mental Health;National Institute of Mental Health;nonbinary;Outcome;peer;Peripheral Nervous System;Persons;Phase;Physiological;prevent;psychologic;pubertal timing;Puberty;puberty transition;Regulation;Research;resilience;response;Risk;Risk Factors;risk prediction;Risk Reduction;Same-sex;Severities;sex;social;Social Change;social engagement;Social Functioning;Social Processes;social skills;Stimulus;Strategic Planning;Stress;Symptoms;Testosterone;Time;Youth

PROJECT_TITLE: Examining Stress and Arousal Across Pubertal Development in ASD

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Burden of Illness;Climate-Related Exposures and Conditions;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Social Determinants of Health;Valley Fever

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative This project addresses gaps in our understanding of the kinds of dust exposures, and the environmental and social conditions, that increase the incidence of coccidioidomycosis in the southwest. The findings will have wide-ranging benefits for public health, including a better understanding of how people are exposed to the pathogen, the identification of areas and people that are at the highest risk, and predictions of future coccidioidomycosis that can be used to prevent infection in vulnerable groups.

PI_NAMEs: REMAIS, JUSTIN V (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Air;Area;burden of illness;California;Cessation of life;Charge;Chronic;Climate;Climatology;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;Crossover Design;Data;Data Collection;density;design;Development;Disease;Disease Outbreaks;Dose;Droughts;Dust;Economic Burden;Economics;Elderly;Environment;environmental intervention;Environmental Risk Factor;Environmental Wind;Epidemic;Epidemiology;Event;experience;Exposure to;fungus;Future;Goals;Heterogeneity;high risk;High temperature of physical object;Hospitalization;Human;Incidence;Individual;Infection;Infection prevention;infection rate;infection risk;Influenza;Inhalation;Knowledge;Laboratories;Lung infections;Measures;Meningitis;Methods;Modeling;Monitor;novel;pathogen;Pathogen detection;pathogen exposure;Pattern;Performance;Persons;Population;Population Analysis;predictive modeling;Proliferating;prospective;Public Health;Rain;Records;remote sensing;Reproduction spores;Research;Resolution;response;Retrospective cohort;Risk;Risk Factors;Sampling;Seasons;Social Conditions;sociodemographics;Soil;Source;spatiotemporal;statistical and machine learning;Subgroup;Symptoms;temporal measurement;Testing;Time;timeline;transmission process;Variant;Vulnerable Populations

PROJECT_TITLE: Integrating epidemiologic and environmental approaches to understand and predict Coccidioides exposure and coccidioidomycosis emergence

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Human Genome;Lung;Rare Diseases;Scleroderma

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE In the proposed research, we aim to elucidate the mechanisms involved in the lipofibroblast to myofibroblast transition in the lungs of a mouse model of systemic sclerosis. Through this research, we will gain insight into disease mechanism and hope to reveal novel treatment targets for interstitial lung disease in systemic sclerosis.

PI_NAMEs: YOUNG, ARISSA C (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Affect;Agonist;ATAC-seq;Autoimmune;Bioinformatics;Bleomycin;career development;Cells;Chromatin;circadian;Collagen Type I;Complication;Core Facility;Data;Differentiation Antigens;Disease;Down-Regulation;Equipment;experimental study;Extracellular Matrix;falls;fatty acid oxidation;Fibroblasts;Fibrosis;Freezing;Future;Gene Expression;Genes;Genetic Transcription;Genomics;Histology;Homologous Protein;human disease;Injections;insight;Interstitial Lung Diseases;Laboratories;lipid biosynthesis;lipid metabolism;long chain fatty acid;Lung;lung injury;Mediating;Mediator;Molecular;Morbidity - disease rate;mortality;mouse model;multiple omics;Mus;Myofibroblast;North America;novel;novel strategies;Pathology;Patients;Persons;PPAR gamma;Production;Protein translocation;Proteins;Regulation;Research;Rheumatism;Role;Sclerosis;single-cell RNA sequencing;skills;Structure of parenchyma of lung;Systemic Scleroderma;Technology;text searching;Time;Tissue Harvesting;Tissues;Training;transcriptome sequencing;Transitional Cell;United States;Up-Regulation

PROJECT_TITLE: The Lipofibroblast to Myofibroblast Transition in Systemic Sclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (M3)]


NIH_SPENDING_CATS: Clinical Research;Genetics;Kidney Disease;Precision Medicine

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Inflammation and tubular injury are key factors in progression of APOL1- mediated chronic kidney disease (CKD). This research examines differences in tubular injury and inflammation biomarkers in APOL1- and non- APOL1 mediated CKD. This study will utilize novel CKD biomarkers and genomic data to advance the field of precision medicine in a population of Black individuals disproportionately affected by CKD.

PI_NAMEs: ILORI, TITILAYO OMOLARA (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acceleration;Affect;Africa;Africa South of the Sahara;African;African American population;African ancestry;Aliquot;Ancillary Study;Apolipoproteins;Biological Markers;Black Populations;Cells;Cessation of life;Chronic Kidney Failure;Clinical;Clinical Data;cohort;Creatinine;Data;Demographic Factors;Development;Dialysis procedure;Diet;Disease Progression;Early identification;Elements;End stage renal failure;Endothelial Cells;Enrollment;evidence base;follow-up;Funding;Future;gene interaction;Genes;genomic biomarker;genomic data;Genotype;Ghana;Glomerular Filtration Rate;Health;high risk;Human;Hypertension;immune activation;Immunologic Markers;In Vitro;in vivo;Incidence;Individual;Inflammation;inflammatory marker;Inherited;Injury;Interferon alpha;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Life;Measurement;Measures;Mediating;Natural Immunity;Nigeria;novel;Participant;Pathway interactions;Patients;Persons;Phenotype;Plasma;podocyte;precision medicine;prognostic significance;Prospective cohort;Proteins;rat KIM-1 protein;recruit;Renal function;Research;Risk;risk variant;Role;Sample Size;Sampling;Serum;Testing;Time;TNF gene;TNFR-Fc fusion protein;TNFRSF1A gene;Transplantation;Tubular formation;urinary;Urine;Urokinase Plasminogen Activator Receptor;Variant

PROJECT_TITLE: ApolipoproteinL1 Genotypes and Biomarkers of Immune Activation and Tubular Injury


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health;Violence Research

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE This project will determine whether adversity exposure impacts parent-child linguistic interactions and how the parent’s own childhood history of adversity influences language use with their child. Using observational methods, this project will clarify the role of the parent’s language input on child language outcomes within an intergenerational framework.

PI_NAMEs: SELIN, CLAIRE  (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Adolescent;Adult;adverse childhood events;Adverse event;Age;Area;Biological;biological adaptation to stress;Child;Child Abuse and Neglect;Child Language;Childhood;childhood adversity;Chronic;chronic depression;Code;Data Analyses;Data Collection;Data Set;design;Dimensions;Discipline;Education;Effectiveness;Endocrine system;Environment;Environmental Risk Factor;epigenome;expectation;Failure;Functional disorder;General Population;Generations;Genes;Genetic;Genetic Transcription;Growth;health of the mother;Healthcare;Heritability;Household;Immune system;Individual;Interdisciplinary Study;interest;intergenerational;Intervention;intimate partner violence;Justice;Knowledge;Language;Language Development;Language Development Disorders;language impairment;language outcome;Left;Life Cycle Stages;Linguistics;Link;maltreatment;Mediating;Methods;Modeling;Nature;neurodevelopment;next generation;novel;Outcome;Parent-Child Relations;parental influence;parental role;Parents;Pathway interactions;Play;Population;Productivity;Prospective Studies;Psychopathology;Recording of previous events;Reporting;Research;Research Personnel;Risk;Risk Factors;Role;Sampling;Science;social;Socioeconomic Status;Special Education;Structure;Substance Use Disorder;System;Time;United States;Video Recording;Violence;Work;Youth

PROJECT_TITLE: Intergenerational Adversity Exposure and Language Acquisition

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-B (03)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE  With increasing recognition that all treatments will not suit all patients, and that no singular treatment is likely to cure, prevent, or stop the onset or progression of Alzheimer’s dementia, it is of critical importance to pursue a precision medicine approach to understand which therapies will be most beneficial and for whom. This project aims to fill an unmet critical need in the Alzheimer’s field to examine Alzheimer’s risk in response to treatment by leveraging existing trial data from major, field-changing studies. This work could inspire new trial designs that sharpen their lens towards phenotypic risk based on factors such as sex/gender, APOE4 status, baseline levels of amyloid and tau, and overall genetic risk.

PI_NAMEs: PA, JUDY  (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Activities of Daily Living;Age;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;analysis pipeline;apolipoprotein E-4;arm;Back;Binding;Biological Markers;Brain imaging;brain magnetic resonance imaging;brain volume;carrier status;Characteristics;Cholinesterases;Clinical dementia rating scale;Clinical Trials;Cognition;Cognitive;Communities;complex data;Data;Data Aggregation;data harmonization;Data Set;Dedications;design;donepezil;Expeditions;functional outcomes;Future;Gender;Genetic;genetic analysis;Genetic Risk;Genotype;Goals;Grouping;Guidelines;hazard;Homozygote;Hypertension;Immunotherapy;Impaired cognition;Individual;insight;Institution;Investigation;Knowledge;lens;lifestyle intervention;Liquid substance;men;Meta-Analysis;Methods;Mind;modifiable risk;Monoclonal Antibodies;neuroimaging;Neurology;Outcome;Participant;Pathology;Patients;Persons;Pharmaceutical Preparations;Phenotype;Placebos;Plasma;Positron-Emission Tomography;pre-clinical;precision medicine;Prediction of Response to Therapy;prevent;profiles in patients;public-private partnership;Randomized;Regulation;Research Design;Resources;response;Risk;Risk Factors;risk variant;Role;Sampling;Sampling Studies;sex;Specific qualifier value;Statistical Models;Subgroup;Sum;tau aggregation;tau Proteins;Technology;Testing;Traction;treatment arm;treatment effect;Treatment outcome;treatment responders;treatment response;treatment trial;trial design;Woman;Work

PROJECT_TITLE: Leveraging 30 years of Alzheimer's disease clinical trials data to decipher phenotypic response to treatment

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Alcohol-related intimate partner aggression (IPA) is a significant public health concern, especially among couples from low-income communities. The proposed study seeks to examine how social isolation and social norm perceptions in in-person versus virtual social networks are associated with alcohol use and IPA among high-risk, disadvantaged couples. This research has the potential to provide critical knowledge toward the development of interventions that target social networks for reducing alcohol-related IPA.

PI_NAMEs: HAMMETT, JULIA FRIEDERIKE (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Aggressive behavior;Alcohol consumption;alcohol risk;Alcohols;Behavioral Research;Belief;Collection;Communication;Communities;Couples;Data;Data Analytics;density;Disadvantaged;Evidence based intervention;Foundations;high risk;Individual;insight;Knowledge;Low income;Measures;member;mhealth interventions;Modeling;Names;partner aggression;Perception;Personality;personalized normative feedback;Persons;Population;Privatization;psychologic;Public Health;Reporting;Research;Resources;Risk;Risk Factors;social;Social Environment;Social isolation;social media;Social Network;social norm;Social support;Surveys;Techniques;Testing;Theoretical model;therapy development;United States;virtual

PROJECT_TITLE: Duocentric Social Networks and Alcohol-Related Intimate Partner Aggression among Couples from Low-Income Communities

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2 (AA)]


ADMINISTERING_IC: EB

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Narrative There is a great need to enable scientists to link brain activity to human movement, perception and cognition, and social communication and interaction continuously, in real time, and in naturalistic settings. fNIRS provides such measures but is compromised by challenging hair characteristics limiting image quality. Our advances will dramatically expand the utility of fNIRS to greatly expand the inclusion of subjects while simultaneously improving image quality metrics.

PI_NAMEs: BOAS, DAVID A (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Address;Behavior;Brain;Brain imaging;Characteristics;Cognition;cognitive load;Collaborations;commercialization;Communication;Complex;contrast imaging;density;design;Detection;detection platform;detector;Environment;Failure;Floor;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Grant;Hair;Head;Human;human subject;Image;improved;insight;Link;Measurement;Measures;Miniaturization;miniaturize;Morphologic artifacts;Movement;multisensory;Noise;Perception;Performance;Phase;photomultiplier;Physiologic pulse;Pilot Projects;Population Heterogeneity;prototype;Psyche structure;Research Personnel;Resolution;Safety;Scientist;Signal Transduction;Silicon;Skin;Skin Pigmentation;social communication;Social Interaction;Source;Structure;System;Technology;Testing;Time;Tissues;tool;usability;way finding;wearable device;Work;Workload

PROJECT_TITLE: Expanding Inclusion of All Subjects for Ultra-High Density Wearable fNIRS in the Everyday World

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-G (M1)]


ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative The integration of SIV into the host genome poses a significant barrier to achieving a successful HIV cure. This project seeks to elucidate the host-dependent mechanisms that govern preferences in HIV/SIV integration and the pivotal role SIV integration plays in disrupting host cellular functions; the latter ultimately leads to immune senescence, premature aging of the immune system, and, in some cases, tumorigenesis. By addressing these crucial aspects, my project aims to offer mechanistic insights that can lead to potential therapeutic targets for preventing integration or reversing host-immune dysfunctions triggered by SIV integration.

PI_NAMEs: BOUDRIES, MALIKA  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Animals;antiretroviral therapy;ATAC-seq;Automobile Driving;Award;Cardiovascular Diseases;Cell Physiology;Cells;Cellular Assay;Chromatin;chronic infection;Collaborations;commensal bacteria;comorbidity;cytokine;Data;Data Analyses;data integration;Diabetes Mellitus;Disease Progression;DNA;Early identification;Epigenetic Process;epigenome;Exposure to;Frequencies;Gene Expression;Genes;Genetic Transcription;Genome;global health;healthcare burden;Healthcare Systems;Heterogeneity;HIV;HIV Infections;HIV-1;Homeostasis;Human;Immune;immune function;Immune system;Immune System Diseases;Immunomodulators;immunosenescence;Infection;Inflammation;innovation;insight;Integration Host Factors;integration site;Knowledge;Location;lymph nodes;Macaca mulatta;Malignant Neoplasms;Maps;Molecular;Multiomic Data;nonhuman primate;Outcome Study;Peripheral Blood Mononuclear Cell;Persons;Plasma;Play;predictive modeling;predictive signature;Predisposition;preference;Premature aging syndrome;prevent;programs;Proteins;Provirus Integration;Proviruses;Research;Residual state;Risk;Role;Sampling;senescence;Shapes;single-cell RNA sequencing;Site;SIV;success;Testing;Therapeutic;therapeutic target;Time;transcriptome;tumorigenesis;viral rebound;Virus;Virus Integration;Whole Blood

PROJECT_TITLE: Host-Dependent Mechanisms that Guide the Longitudinal Dynamic of Sites of SIV Integration

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-D (M1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Through a systematic review, we identified research gaps related to social determinants of health and their relationship with dry eye. Leveraging multi-center electronic health records, our proposal seeks to investigate the association between indicators of social determinants and disparities in access to care and unequal prognosis in dry eye patients. By incorporating this routinely collected information as predictors in the rigorously constructed and externally validated prognostic models, our goal is to provide updated evidence, improve disease management, and enhance outcomes for individuals with dry eye.

PI_NAMEs: LIU, SUHSUN  (contact)

PROGRAM_OFFICER_NAME: SHOAIBI, AZADEH

PROJECT_TERMS: access disparities;Address;Adherence;Affect;Age;Anterior;built environment;burden of illness;Caring;Characteristics;Clinical;cohort;Colorado;Cornea;Data;Data Set;density;Diagnosis;Disease;Disease Management;Disease Progression;disorder risk;Disparity;Disparity in diagnosis;Dry Eye Syndromes;Education;Electronic Health Record;Environment;Environmental Risk Factor;Ethnic Origin;Eye;eye center;eye dryness;Film;follow-up;geographic difference;geographic disparity;Geography;global health;Goals;Health;Health Services Accessibility;improved;Individual;Insurance Coverage;International Classification of Disease Codes;intervention program;Investigation;Language;Learning;Measures;medication compliance;National Eye Institute;ocular surface;ophthalmic examination;Ophthalmology;Outcome;Outcomes Research;Patients;Pattern;personalized care;Persons;PhenX Toolkit;Physicians;Play;population based;predictive modeling;Prevalence;Prognosis;prognostic model;Provider;Quality of life;Race;Reporting;Research;research clinical testing;Risk;Risk Assessment;Risk Factors;Sample Size;Site;social determinants;social disparities;social health determinants;societal costs;Specialist;Symptoms;systematic review;Test Result;Testing;therapy development;Time;Universities;Update;Validation;Vision;Visit;Visual;Work

PROJECT_TITLE: Understanding barriers to accessing eye care and their impacts on the prognosis of dry eye disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (02)]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Precision Medicine;Rural Health

ORG_CITY: MARSHFIELD

ORG_NAME: MARSHFIELD CLINIC RESEARCH FOUNDATION

ORG_STATE: WI

PHR: Data collected as part of AoURP is not about one single disease or even a class of diseases; it is about all diseases that can impact the health and wellbeing of all Americans. This resource will foster academic freedom, transparency, and be a trusted dataset for the public and scientists alike.

PI_NAMEs: BURNSIDE, ELIZABETH S;CADMUSBERTRAM, LISA ANNE;FRANCO, ZENO E;HEBBRING, SCOTT JOSEPH (contact);MAHR, TODD A;SHUKLA, SANJAY K

PROGRAM_OFFICER_NAME: PRABHUDAS, IRENE

PROJECT_TERMS: Academy;Acceleration;Adult;Advocacy;Advocate;All of Us Research Program;American;Ancillary Study;Appointment;Area;Asian population;Awareness;biobank;Biomedical Research;Black race;care delivery;care providers;career;Caring;Censuses;Childhood;Clinic;Collaborations;Collection;Communities;community center;community partners;Complex;Computer Literacy;Computers;Consent;Consent Forms;COVID-19 pandemic;Data;Dedications;demographics;Development;disability;Disease;Education;Electronics;Eligibility Determination;Enrollment;Ensure;Environment;Ethics;ethnic diversity;Ethnic Origin;experience;Faith;Family;flexibility;follow-up;Friends;Frontline worker;Genetic;Geography;Health;Health Campaign;health care service organization;Health Personnel;Health system;Healthcare;Healthcare Systems;Hispanic;Hospitals;Hour;Household;human disease;human old age (65+);illiteracy;Indigenous;Individual;individualized prevention;Infrastructure;innovation;Inpatients;Institution;Institutional Review Boards;Intake;Integrated Health Care Systems;interest;Intuition;Letters;Life Style;Link;literacy;Location;Measurement;Medical;medical schools;meetings;member;Mental Health;migration;Minority Groups;Mission;Modeling;Mothers;Native American population;Newborn Infant;Older Population;Outpatients;outreach;pandemic disease;Paper;Parents;Participant;participant enrollment;participant retention;Pediatric Hospitals;pediatrician;Pediatrics;Pharmacy facility;Population;Population Heterogeneity;Positioning Attribute;Precision Health;precision medicine;precision nutrition;Process;Productivity;programs;Provider;racial diversity;Recontacts;recruit;Refugees;Research;Research Personnel;Research Training;retention rate;retiree;Rural;rural area;Rural Population;Scientist;Site;social;Social Work;Societies;Source;Southeastern Asia;Special Population;success;Surveys;Technology;Time;United States;United States National Institutes of Health;Universities;Urban Community;Vietnam;Visit;Walking;War;Wisconsin;Youth

PROJECT_TITLE: AOU WI Area of Interest 1: Community, Participant and Provider Engagement, Enrollment...


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases;Liver Disease;Neurosciences;Nutrition

PHR: This proposal investigates undefined neuronal mechanisms that orchestrate metabolic shifts during bacterial infections. By employing innovative methodologies, the aim is to elucidate the role of the brain-liver axis in modulating metabolic responses, thereby bolstering host survival during infections. By intertwining neuroscience and immunology, this research can unveil new dimensions in host defense strategies, examining both neuronal and hepatic responses to infections.

PI_NAMEs: NIKKANEN, JONI  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Anorexia;anorexic;Bacterial Infections;BCL6 gene;Biotin;Blood;Brain;brain control;Cells;CRISPR/Cas technology;cytokine;designer receptors exclusively activated by designer drugs;Dimensions;Disease;Escherichia coli;Escherichia coli Infections;experience;Fasting;Female;Genetic;Glucose;Glycogen;Goals;Hepatic;Host Defense;Host Defense Mechanism;House mice;Housing;Human;Hyperlipidemia;Hypothalamic structure;immune clearance;Immune response;Immunologist;Immunology;immunopathology;improved;in vivo;Infection;Inflammatory;innovation;insight;Invaded;Ligase;lipid metabolism;Lipids;Lipoproteins;Liver;liver function;male;Metabolic;Metabolic Control;Metabolism;Methodology;Methods;Molecular;Monitor;mouse model;Mus;neuromechanism;Neurons;Neurosciences;novel;Nutrient;Organ;Organism;pathogen;Pathogen detection;Pathogenicity;patient subsets;Peripheral;Phenotype;Physiological Processes;post-doctoral training;programs;Proteins;Proteomics;Regulation;Research;Research Proposals;response;Role;Sex Bias;Signal Transduction;Signaling Molecule;Source;stem;System;Temperature;Testing;Training;transcription factor;Vitamins

PROJECT_TITLE: Decoding the Brain-Liver Axis: Uncovering mechanisms of host defense


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative: This research project focuses on developing and optimizing ribozymes for the selective killing of cancer cells carrying specific driver mutations, using the JAK2-V617F driver mutation in myeloproliferative neoplasms as a proof-of-principle. The proposed work uses a combinatorial approach called RABADOCS to identify highly specific and efficient ribozyme variants that can trans-splice and replace target mRNA sequences with a sequence encoding a cytotoxic peptide, inducing cell death in cancer cells while sparing healthy ones. The ultimate goal of this three-year project is to demonstrate the feasibility of using these engineered ribozymes as a novel therapeutic strategy for treating myeloproliferative neoplasms and potentially other cancers with prevalent missense mutations, offering a promising avenue for precision cancer treatment.

PI_NAMEs: LEIER, ANDRÉ  (contact);MULLER, ULRICH F

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Address;Bar Codes;Base Pairing;cancer cell;cancer therapy;cancer type;Catalogs;Catalytic RNA;Cell Death;Cell Death Induction;cell killing;Cell Line;Cell Proliferation;Cell Survival;Cells;Cessation of life;Chimeric Proteins;Code;combinatorial;Consumption;cytotoxic;Databases;design;Diphtheria Toxin;Disease;driver mutation;Engineering;Event;FarGo;Funding;Genes;Goals;Guanine;Hematopoietic stem cells;High-Throughput Nucleotide Sequencing;improved;Individual;Introns;JAK2 gene;KRAS2 gene;Libraries;Malignant Neoplasms;Mediating;Messenger RNA;Methods;Missense Mutation;Mus;mutant;Mutate;Mutation;Myeloproliferative disease;novel;novel strategies;novel therapeutic intervention;Oncogenes;Peptides;PIK3CA gene;Population;Precision cancer therapy;protein aminoacid sequence;Proteins;Research Project Grants;RNA;RNA Splicing;Sampling;Sensitivity and Specificity;Site;Somatic Mutation;Specificity;stemness;System;Tail;targeted treatment;Technology;Testing;Tetrahymena thermophila;Thymine;Time;Toxic effect;Toxin;TP53 gene;Trans-Splicing;Translating;Translations;Uridine;Variant;Work

PROJECT_TITLE: Ribozyme-mediated killing of cells harboring cancer driver mutations

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: PROJECT NARRATIVE Myeloperoxidase (MPO), which gives the distinctive green tinge in pus and phlegm, is the key enzyme that generates chlorine bleach in white blood cells for bacterial killing, and patients lacking this enzyme often contract fungal infection and develop inflammatory diseases. Because the existing MPO-deficient mouse model fails to reproduce the human disease, an accurate and faithful animal model is critically needed. The current application has laid out a comprehensive plan to characterize a novel MPO-deficient rabbit model to meet the need for basic research of MPO-related infection and inflammatory diseases.

PI_NAMEs: WANG, GUOSHUN  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Animal Model;Anions;Anti-Inflammatory Agents;Antiatherogenic;antimicrobial;Arbitration;Atherosclerosis;Azurophilic Granule;Basic Science;Biology;Candida albicans;Cardiovascular Diseases;Cardiovascular system;Cells;Chlorides;Chlorine;Chronic Granulomatous Disease;Circulation;Clinical;Clinical Data;Contracts;CRISPR/Cas technology;Data;Development;dextran sulfate sodium induced colitis;Disease;Disparity;effective intervention;Electrons;Environment;Enzymes;Exhibits;experience;Failure;fungus;gene editing technology;Genes;germ free condition;heme a;Hereditary Disease;Host Defense;Human;Human Biology;human data;human disease;human model;Hydrogen Peroxide;Hypochlorous Acid;Immune system;Immunity;Individual;Infection;Inflammation;Inflammatory;Inherited;Kidney Diseases;Knock-out;Knockout Mice;Leukocytes;Lung;Lung infections;Mediating;microbial;microbicide;Modeling;Molecular;mouse model;Mus;Mycoses;NADPH Oxidase;Neurons;neutrophil;novel;Organ;Oryctolagus cuniculus;Oxidants;oxidation;Pathogenesis;Pathologic;Patients;Peroxidases;Phagocytes;Phenotype;Precipitation;Predisposition;Proteins;Pulmonary Inflammation;Pus;recruit;Research;research and development;Rest;Rheumatoid Arthritis;Role;Septic Shock;skin disorder;Stress;System;Testing;Therapeutic;therapeutic development;Tissues;tool;Validation

PROJECT_TITLE: Development of a Rabbit Model for Myeloperoxidase Deficiency

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ED_INST_TYPE: SCH OF BUSINESS/PUBLIC ADMIN

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative Active Viral Hepatitis Diagnostics to Support Prevention/Treatment of HCC Hepatocellular carcinoma (HCC) is a highly lethal cancer with over 80% of the cases occurring in low resource settings. Chronic hepatitis C (HCV) infection is major risk factor for HCC development. The goal of this proposal is to develop and validate a diagnostic test for HCV infections for use in low-and-middle-income-countries to identify patients for treatment thus reducing their risk of developing HCC.

PI_NAMEs: HAWKINS, CLAUDIA A;MCFALL, SALLY MAUREEN (contact)

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: acceptability and feasibility;Administrator;Adult;Age;anti-hepatitis C;Biological Assay;Blood capillaries;Blood specimen;Cancer Etiology;Caring;Cessation of life;Characteristics;Chronic Hepatitis C;Cirrhosis;Clinical Sensitivity;commercialization;Communicable Diseases;Complex;cost;Country;COVID-19 test;Data;design;detection limit;Development;Devices;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic tests;Enrollment;Enzyme Immunoassay;Epidemic;FDA Emergency Use Authorization;Fingers;Future;Genotype;Geographic Locations;Global Awareness;global health;Goals;Health Technology;Hepatitis B Virus;Hepatitis C;Hepatitis C Incidence;Hepatitis C Therapy;Hepatitis C Viremia;high risk;HIV;Human Resources;Improve Access;improved;Incidence;Infection;Infrastructure;innovation;Kinetics;Laboratories;Left;Licensing;Life;Link;Liver;Liver diseases;low and middle-income countries;Malignant Neoplasms;Molecular;mortality;Nigeria;Nigerian;novel;Participant;patient population;Patients;Performance;Persons;Plasma;point of care;point of care testing;point-of-care diagnostics;Polymerase Chain Reaction;Population;portability;preference;Prevalence;prevent;Prevention;preventive intervention;Primary carcinoma of the liver cells;prospective;Public Health;Reagent;reagent testing;Resource-limited setting;Reverse Transcription;Risk;Risk Factors;RNA;rural area;Sampling;screening;Sensitivity and Specificity;Serology;Serology test;sex;Specificity;System;Technology;Testing;Time;touchscreen;urban area;usability;Venous;Viral hepatitis;Viral Load result;viral RNA;Virus;virus testing;Visit;Whole Blood

PROJECT_TITLE: Active HCV diagnosis to support prevention of HCC in LMICs

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-Q (M1)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric;Regenerative Medicine

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project narrative The loss of heart cells after heart attack is a major cause of heart failure. The newborn mammalian hearts can regrow back after heart attack while the adult mammalian hearts loss the capacity. The proposed research is investigating the molecular mechanisms underlying the heart regrowth capacity in the newborn hearts. Understanding the mechanisms will provide a mechanistic base for designing new treatment for heart failure.

PI_NAMEs: ZHANG, MANLING  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Adult;Age;Back;base;biological adaptation to stress;Biology;Birth;BMP10 gene;Bone Morphogenetic Proteins;Brain;brain abnormalities;Calcineurin;Calcium;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiogenesis;Cardiomyopathies;Cell Cycle;Cells;Cessation of life;Clinical Research;Complex;Data;design;Development;Disease;drug development;Embryo;epigenetic regulation;Family;fetal;Genetic Transcription;Goals;Growth;Heart;heart cell;Heart failure;Heart Injuries;High-Throughput Nucleotide Sequencing;Hypertrophy;Impairment;induced pluripotent stem cell;integration site;knock-down;Knock-out;Knockout Mice;Ligands;LoxP-flanked allele;Mediating;member;Messenger RNA;Methylation;Methyltransferase;Microfilaments;Mitochondria;Modification;Molecular;Morphogenesis;Mouse Mammary Tumor Virus;Mus;Myocardial Infarction;Myosin Heavy Chains;Neonatal;neonatal mice;neonatal period;Nerve;Neurons;Newborn Infant;nuclear factors of activated T-cells;overexpression;Pathway interactions;Phase;Phospholipase C;Play;postnatal;programs;Proliferating;Protein Isoforms;Rattus;regeneration following injury;Regenerative capacity;regenerative therapy;Regulation;Research;research and development;RNA;Role;Signal Transduction;System;Testing;tissue regeneration;Transcript;Ventricular Cardiac alpha-Myosin;WNT Signaling Pathway

PROJECT_TITLE: Mettl14 mediated mRNA methylation orchestrates postnatal cardiac development

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-N (M1)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE Coronary Microvascular Disease (CMVD) accounts for 30-50% of ischemic heart disease and can lead to angina, heart failure with preserved ejection fraction, and cardiovascular death. In prior and preliminary studies, we have identified a single nucleotide polymorphism in the Friend of GATA 2 (FOG2), termed FOG2S657G, which is associated with CMVD and increases expression of β1-adrenergic receptor. In this proposal, we use novel mouse and induced pluripotent stem cell models to determine the link between FOG2S657G, increased β1-adrenergic receptor expression, and increased cardiac work to promote CMVD.

PI_NAMEs: GUERRATY, MARIE A (contact)

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: ADRB1 gene;Adrenergic Receptor;Affect;antagonist;Automobile Driving;Binding;Biological Assay;Blood flow;Blood Pressure;Cardiac;Cardiac Myocytes;Cardiovascular system;Cessation of life;Clinical;Co-Immunoprecipitations;Code;cofactor;cohort;Complex;Coronary;CRISPR/Cas technology;Data;Development;Disease;Echocardiography;EFRAC;experimental study;Family;Female;Friends;Future;GATA4 gene;Gene Expression;Gene set enrichment analysis;Genes;Genetic Transcription;Goals;Heart;Heart Contractilities;Heart failure;Heart Rate;Human;human induced pluripotent stem cells;Implant;In Vitro;in vivo;induced pluripotent stem cell;insight;Link;Luciferases;Maintenance;male;Measurement;Measures;Mediating;Microvascular Dysfunction;Molecular;Morphology;mouse model;Mus;Myocardial;Myocardial Infarction;Myocardial Ischemia;myocyte-specific enhancer-binding-factor 2C;novel;Ontology;Oxygen;Pathogenesis;Pathway Analysis;Pathway interactions;pluripotent stem cell differentiation;preservation;pressure;promoter;protein expression;receptor expression;Receptor Signaling;Receptors, Adrenergic, beta-1;Reporting;Role;Single Nucleotide Polymorphism;single photon emission computed tomography;stem cell model;System;targeted treatment;Telemetry;Testing;therapeutic target;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transfection;Variant;Vascular blood supply;Work

PROJECT_TITLE: Friend of GATA 2 (FOG2) S657G regulates ß1-adrenergic receptor and cardiac work to promote Coronary Microvascular Disease