ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: There is a critical need for a diverse group of highly trained basic and clinical oral health researchers. If effective preventive therapies and cures for the many diseases associated with the oral, dental and craniofacial complex are to be discovered and applied, a cadre of oral health researchers must be trained to work in interdisciplinary teams and to maintain the highest standards for ethical and responsible conduct of rigorous scientific research. The main objective of this comprehensive training program is to produce oral health researchers who can apply state-of-the-art technologies to generate new knowledge, translate that information to applied therapies, and rigorously evaluate the outcomes of implementation of novel preventive or treatment strategies to improve human health.

PI_NAMEs: LEMOS, JOSE A (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Appointment;Area;Autoimmunity;Biology;Biomedical Engineering;biomedical informatics;bone;career;Clinical;clinical investigation;Clinical Sciences;college;Communicable Diseases;Computational Biology;craniofacial;craniofacial complex;Dental;Dentistry;Detection;Disease;Doctor of Philosophy;doctoral student;Education;experience;flexibility;Florida;Goals;Head and Neck Cancer;Health;Human Microbiome;implementation science;Individual;Interdisciplinary Study;Knowledge;Medicine;Mouth Diseases;National Institute of Dental and Craniofacial Research;Oral;oral biology;Oral health;oral infection;post-doctoral training;Postdoctoral Fellow;Prevention;Productivity;programs;Research;Research Personnel;Resources;response;Salivary Glands;Science;Scientist;skills;stem cell biology;Students;Training;Training Programs;Translating;Translational Research;Universities;virology

PROJECT_TITLE: Comprehensive Training Program in Oral Biology


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: WINSTON-SALEM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Interleukin 6 (IL-6) trans-signaling is a non-canonical IL-6 signaling paradigm that is a modifier of inflammatory disease and enhanced by the inheritance of the common mutation IL6R Asp358Ala. We will use our robust, novel C57BL/6 Il6raE357A mouse model of enhanced IL-6 trans-signaling to investigate whether enhanced IL-6 trans-signaling worsens cardiac function and fibrosis in a model of cardiac pressure overload, and whether IL-6R blocking therapeutic interventions may will prevent or attenuate cardiac fibrosis and HF, and we will utilize spatial transcriptomics to identify the type and location of cells in cardiac tissue that are responding to IL-6 trans- signaling. The results of this study will provide insight into how IL-6 trans-signaling modifies disease pathology, cardiac fibrosis, and heart failure, and response to IL-6R blocking therapies.

PI_NAMEs: HAWKINS, GREGORY A (contact);MELENDEZ, GISELLE C

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Affect;African;antifibrotic treatment;aorta constriction;Attenuated;Binding;Biological Assay;Biological Markers;Biological Models;Blood Vessels;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;cell type;Cells;Clinical;Complex;coronary fibrosis;Data;Development;Disease;disorder risk;effective therapy;Ethnic Origin;European;Exhibits;experimental study;extracellular;Fibrillar Collagen;Fibroblasts;Frequencies;Functional disorder;Gene Expression Profile;General Population;Genetic Models;Genetic Polymorphism;Genotype;glycoprotein 130;Goals;Heart failure;heart function;Hepatocyte;High Prevalence;high risk;Histologic;Human;Inflammatory;insight;Interleukin 6 Receptor;Interleukin-6;interstitial;Left;Left Ventricular Dysfunction;Leukocytes;Link;Location;Measures;Membrane;Modeling;mouse model;Mus;Mutation;Myocarditis;Names;National Institute of Allergy and Infectious Disease;Native American Ancestry;novel;Outcome;Pathogenesis;Pathology;Pathway interactions;patient stratification;Patients;pharmacologic;Phase II Clinical Trials;Phenotype;Play;Population;pressure;prevent;Production;Protein Isoforms;response;Risk;Role;Signal Transduction;Stratification Factors;targeted treatment;Therapeutic Intervention;Tissues;transcriptomics;treatment response;treatment strategy;Variant;Ventricular

PROJECT_TITLE: A novel, genetic model of IL-6 trans-signaling to interrogate cardiac fibrosis pathology

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: GENT

ORG_COUNTRY: BELGIUM

ORG_FIPS: BE

ORG_NAME: FLANDERS INTERUNIV INST BIOTECHNOLOGY

PHR: NARRATIVE The aggregation and deposition of Amyloid-beta and tau are crucial pathological hallmarks of Alzheimer’s Disease (AD), but it remains unknown why certain cells and brain regions are vulnerable to their aggregation, and others less. The proposed project from the Switch Laboratory in VIB Flanders Institute for Biotechnology aims to perform a systematic search for potential interacting partners based on the sequence- and structure- specificity of aggregation in a project that starts with a computational search and then proceeds to verify potential interactor proteins in cells, in live animals, and using an extensive array of biophysics assays. This research may lead to a major breakthrough in current treatments of AD by providing a structural model with which the entire set of proteins within brain cells can be screened for potential interactors with the aggregates normally found in AD, providing potential therapeutic value.

PI_NAMEs: ROUSSEAU, FREDERIC ;SCHYMKOWITZ, JOOST  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta accumulation;abeta deposition;Affect;Alzheimer's Disease;Alzheimer's disease model;Amyloid;Amyloid beta-Protein;amyloid formation;Animals;beta amyloid pathology;Binding;Biological;Biological Assay;biophysical techniques;Biophysics;Biotechnology;Brain;brain cell;Brain region;candidate identification;Cell Culture System;Cell Line;Cell model;Cells;Complex;computational pipelines;Data Set;Deposition;Disease;Event;extracellular;Fluorescence Resonance Energy Transfer;in silico;In Situ;In Vitro;in vivo;Laboratories;Length;Mediating;Modeling;Molecular;Morphology;mouse model;Neurons;overexpression;Pathologic;Pathology;Play;Proteins;Proteome;Proteomics;proteostasis;Recombinant adeno-associated virus (rAAV);Reporter;Reproducibility;Research;Research Project Grants;Role;Running;Sequence Homology;Set protein;Site;Software Tools;Specificity;Statistical Data Interpretation;Structural Models;Structure;tau aggregation;tau Proteins;Therapeutic;Therapeutic Effect;vector;Viral

PROJECT_TITLE: Heterotypic amyloid interactions as modulators of selective cellular vulnerability


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Dissemination and Implementation Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Three-quarters of survivors of mechanical ventilation will develop persistent disability. Early mobilization engages patients in physical activity during mechanical ventilation to prevent disability, but has poor adoption into clinical practice. This proposal aims to apply precision medicine to identify patients who are most likely to benefit from early mobilization and elucidate how it can be implemented successfully to extend the benefits of early mobili- zation to patients at risk for long-term disability.

PI_NAMEs: PATEL, BHAKTI KIRAN (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Academy;Address;Adopted;Adoption;Beds;big-data science;career;career development;Caring;Chicago;Chronic disability;Clinical;clinical care;clinical practice;clinical trial implementation;Clinical Trials;Complex;Consolidated Framework for Implementation Research;contextual factors;Critical Care;Critical Illness;Data;Data Analyses;Data Set;Decision Trees;design;Development Plans;disability;Disability prevention;disability risk;Disablement;Early Mobilizations;early phase clinical trial;Early treatment;effectiveness/implementation design;effectiveness/implementation hybrid;effectiveness/implementation trial;efficacy evaluation;Enrollment;evidence base;Evidence based intervention;Evidence based practice;field study;Foundations;functional disability;functional independence;Funding;Future;Goals;high risk;Hospitals;Hour;implementation facilitators;implementation framework;implementation science;implementation strategy;improved;Incentives;innovation;insight;Institution;Intensive Care Units;Intervention;intervention effect;Interview;Investments;K-Series Research Career Programs;Lead;Long term disability;Long-Term Effects;Machine Learning;machine learning method;Mechanical ventilation;Mediating;Medicine;Mentors;Mentorship;Methodology;Methods;mortality;multidisciplinary;Muscle Weakness;Muscular Atrophy;neuromuscular;Outcome;Outcomes Research;participant enrollment;patient engagement;patient subsets;Patients;Penetration;Phenotype;Physical activity;Physical therapy;Population;Populations at Risk;Postdoctoral Fellow;precision medicine;predictive modeling;prevent;Process;Public Health;Publications;Publishing;Qualitative Methods;Quality of life;randomized, clinical trials;Rehabilitation therapy;Research;Resources;Risk;Scientific Advances and Accomplishments;Site;skills;Statistical Methods;Statistical Models;Structure;Survivors;Target Populations;Testing;Training;Translating;treatment effect;Treatment Efficacy;trial design;United States;United States National Institutes of Health;uptake;Vulnerable Populations

PROJECT_TITLE: Early Mobilization: Operationalizing Big Data & Implementation Science to Lead Expansion to ICUs (E-MOBILE-ICU)

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Parkinson's disease (PD) patients treated with deep brain stimulation (DBS) of the subthalamic nucleus (STN) have unpredictable and varied speech outcomes after this treatment. Our research will prospectively document speech performance before, during and 6- and 12-months after STN-DBS in 80 surgically treated patients and compared with 40 non-surgical PD controls. This study will provide unique insights into the role of STN in speech production, document speech outcome in a comprehensive fashion, identify factors that predict functional communication ability 12 months after STN-DBS, and test the feasibility of low frequency DBS in reversing DBS-induced speech declines in order to optimize treatment strategies for those living with PD.

PI_NAMEs: GREENLEE, JEREMY  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Acute;Address;Aftercare;American;Articulation;awake;Behavior;Bilateral;Brain;Characteristics;Cohort Studies;Communication;Control Groups;Data;Deep Brain Stimulation;Deterioration;Development;Disabling;Disease;Disease Progression;disorder control;disparity reduction;effective therapy;Exhibits;experience;Failure;Family;feasibility testing;Frequencies;Future;Goals;human model;Impairment;implantation;improved;insight;Knowledge;Limb structure;Literature;Measures;Microelectrodes;Motor;motor control;motor symptom;Movement;neural model;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurons;neurophysiology;Operative Surgical Procedures;Outcome;Outcome Study;Parkinson Disease;Participant;Patient Selection;Patients;Performance;Persons;Pharmaceutical Preparations;Physiology;Pilot Projects;Postoperative Period;Predictive Factor;preoperative counseling;Prevalence;Production;prospective;Protocols documentation;Quality of life;reduce symptoms;Regression Analysis;Reporting;Research;respiratory;Respiratory physiology;Role;side effect;Source;Speech;STN stimulation;Structure of subthalamic nucleus;Surveys;Techniques;Testing;Therapeutic Effect;Time;tool;treatment optimization;treatment strategy

PROJECT_TITLE: Role of Subthalamic nucleus in Speech and Movement among people with Parkinson’s as Revealed by Intraoperative Recordings and Deep Brain Stimulation

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Plasmodium ovale and Plasmodium vivax are resistant to many current malaria control interventions, due to evolutionary advantages affecting transmission and relapse. They are increasingly identified in infections in Africa and, in the case of vivax, potentially evolving to overcome limitations to red blood cell invasion. This proposal seeks to provide the evidence base and to develop tools needed to face challenges associated with control of relapsing malarias by providing fundamental knowledge about the infectious reservoir and vectors involved in transmission, developing tools to understand relapse and defining mechanisms by which vivax malaria may be evolving to expand its range and impact in Africa.

PI_NAMEs: DINGLASAN, RHOEL DAVID RAMOS;JULIANO, JONATHAN J (contact);NSANGO, SANDRINE

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Affect;Africa;African;Anopheles Genus;Anti-malarials;Asia;Binding Proteins;Biological;Biological Assay;Biology;Blood;Cameroon;Cells;Central Africa;Clinic;Communities;Community Surveys;Country;Culicidae;deep sequencing;density;design;Diagnostic;Disease;epidemiologic data;Epidemiologist;Erythrocytes;Ethiopia;evidence base;Face;feeding;genome sequencing;genomic locus;genomic tools;Genomics;Genotype;Human;Immune;Individual;Infection;insight;Intervention;Invaded;Investigation;Investments;Kenya;Knowledge;Larva;Left;Life Cycle Stages;Ligands;Liver;Longitudinal cohort;Madagascar;Malaria;malaria infection;Molecular;molecular diagnostics;Monitor;neglect;Parasitemia;Parasites;Pattern;Periodicity;Plasmodium falciparum;Plasmodium ovale;Plasmodium vivax;point of care;point-of-care diagnostics;Prevalence;Production;Proteins;Proteomics;recurrent infection;Relapse;relapse prediction;Research;Research Personnel;resilience;Resistance;Sampling;screening;Shapes;single cell sequencing;Site;Skin;Sorting;Surveys;Tanzania;Time;tool;transcriptomics;transmission process;Uganda;vector;vector competence;Vivax Malaria;whole genome;Work

PROJECT_TITLE: Relapsing malaria in Africa: mechanisms for persistence amid falciparum decline

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Combing auditory and visual speech information (multisensory integration) is important to an infant’s ability to learn to speak. Non-invasive multimodal brain imaging and infant vocalization analysis is used to investigate 1) the neural correlates of multisensory integration in infants, 2) brain-behavioral associations, and 3) whether multisensory brain measures obtained at 9-12 months can predict speech/language outcome and delays at 2 years old.

PI_NAMEs: SHEN, GUANNAN  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: 2 year old;3 year old;Acoustics;Adult;Age;Age Months;Area;audiovisual speech;Auditory;Auditory area;Award;base;Behavior assessment;Behavioral;behavioral outcome;Brain;brain behavior;Brain imaging;Brain region;Broca's area;Child;Clinical;Code;Complex;Data;Databases;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Early Diagnosis;Early Intervention;Equipment and supply inventories;extreme prematurity;Face;Failure;Future;Gestational Age;Goals;imaging study;Imaging Techniques;improved;Incidence;indexing;Individual;Infant;Inferior;Institution;Intervention;K-Series Research Career Programs;Knowledge;Language;Language Delays;Language Development;Language Disorders;language outcome;Learning;Life;Linguistics;Link;Lip structure;Magnetoencephalography;Measures;Modality;Movement;Multimodal Imaging;multimodality;multisensory;neural;neural circuit;neural correlate;neuromechanism;neurophysiology;Parents;Pathway interactions;Perception;Phonetics;Play;Population;Premature Infant;Prevalence;Process;recruit;Research;Resources;response;Risk;Role;Sampling;Scientist;Sensory;sensory integration;Sensory Process;Speech;Speech Delay;Speech Development;Speech Disorders;speech processing;Speech Sound;Stimulus;Structure;System;Technology;Testing;Time;Training;Training Support;verbal;Visual;Visual Cortex;visual information;visual speech;vocalization;Voice;white matter

PROJECT_TITLE: Infant multisensory integration and speech development: A multimodal imaging study

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Pregnancy and breastfeeding are periods of high HIV acquisition risk for African women. Oral pre-exposure prophylaxis (PrEP) can prevent HIV infection, yet PrEP adherence during pregnancy and postpartum is sub- optimal due to specific issues women face during this period that could be addressed by real-time SMS communication with a health worker. We propose a randomized trial to determine the effect of a bidirectional SMS communication tool (mWACh-PrEP) on PrEP adherence during pregnancy and postpartum and we will collect data on implementation and cost to expedite translation into routine practice.

PI_NAMEs: KINUTHIA, JOHN ;PINTYE, JILLIAN  (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Adherence;African Women;antenatal care;antiretroviral therapy;arm;Behavioral;Birth;Blood;Breast Feeding;care delivery;care outcomes;Characteristics;Childbirth;Clinic;cofactor;Collaborations;Communication;Communication Tools;cost;cost effective;cost effectiveness;cost estimate;cost-effectiveness ratio;Counseling;Country;critical period;Data;Diphosphates;disability-adjusted life years;Dose;Dryness;Event;Face;Focus Groups;follow-up;Future;Growth;Hair;Health;Health system;High Risk Woman;HIV;HIV Infections;HIV risk;HIV Seronegativity;implementation outcomes;improved;Incidence;incremental cost-effectiveness;Individual;Intervention;Intervention Studies;Interview;Kenya;Life;Maternal and Child Health;Maternal Health;member;Mental Depression;microcosting;Modeling;Mother-to-child HIV transmission;motherhood;Mothers;Motivation;Neonatal Mortality;Nurses;Oral;Outcome;Patient Self-Report;Patients;Perinatal;perinatal outcomes;Pharmaceutical Preparations;pill;Population;Positioning Attribute;Postpartum Period;Postpartum Women;pre-exposure prophylaxis;Pregnancy;pregnant;Pregnant Women;Prevalence;prevent;Prevention;Prevention Research;primary outcome;Proctor framework;Provider;Qualitative Evaluations;Randomized;randomized trial;Readiness;Recommendation;Reporting;Research Infrastructure;Risk;Risk Behaviors;Risk Factors;routine practice;scale up;secondary outcome;side effect;skills;Spottings;standard of care;Symptoms;Tenofovir;theories;therapy adherence;Time;Time and Motion Studies;tool;Translations;trial comparing;two way texting;Use Effectiveness;Visit;Woman;World Health Organization

PROJECT_TITLE: mWACh-PrEP: A SMS-based Support Intervention to Enhance PrEP Adherence during Pregnancy and Breastfeeding

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DALLAS

ORG_DEPT: DERMATOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative: Melanoma is the deadliest type of skin cancer because it rapidly and widely metastasizes. While cancer cells require significant metabolic rewiring for metastasis, the metabolic pathways essential for melanoma metastasis are poorly understood. Here, we propose to identify the critical metabolic functions of the metastatic suppressor GAPDHS (glyceraldehyde 3-phosphate dehydrogenase, spermatogenic) and determine its role in melanoma patients.

PI_NAMEs: GILL, JENNIFER GIBSON (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Award;biobank;Biological Markers;Biological Models;Biology;biomarker development;Biometry;cancer cell;Carbon;career;Catalytic Domain;Categories;Cells;Cessation of life;Citric Acid Cycle;Clinical;clinical practice;comparison control;Data;Dedications;Dependence;Dermatology;Disease;Distant;Enzymes;Equilibrium;Excision;experience;Glucose;glucose metabolism;Glyceraldehyde-3-Phosphate Dehydrogenases;Glycolysis;Goals;high risk;Human;Immunotherapy;improved outcome;in vivo;in vivo Model;Infusion procedures;interest;Isotopes;Knowledge;knowledge base;Laboratories;Malignant Neoplasms;Mediating;Medical center;Melanoma;melanoma biomarkers;Melanoma Cell;Melanoma patient;Mentors;Mentorship;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Metastatic Melanoma;Molecular;Mutate;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Nutrient;Nutrient availability;Operative Surgical Procedures;Organ;Oxidation-Reduction;Oxidative Stress;Pathway interactions;patient derived xenograft model;Patients;Primary Neoplasm;Process;professor;programs;Pyruvate Carboxylase;Regulation;Research;Research Personnel;Resources;Role;Sampling;Site;Skin Cancer;targeted treatment;Techniques;Testing;Texas;Therapeutic;therapeutic target;therapy resistant;Time;tool;Training;transcriptome sequencing;tumor metabolism;tumor progression;Universities

PROJECT_TITLE: Investigating the role of GAPDHS in melanoma metabolism and metastasis

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Nutrition;Pediatric;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Many children in underserved communities face food insecurity, which can adversely impact behavioral disorders. The study will use medical claims data linked to educational outcomes for Arkansas public schoolchildren to test whether school meal delivery options that make it easier to participate in child nutrition programs lead to improvements in discipline and academic performance at school. The study will also determine whether school meal delivery policies can reduce the diagnosis of behavioral disorders and associated healthcare utilization.

PI_NAMEs: THOMSEN, MICHAEL R. (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Academic achievement;Address;Adolescent;Adopted;Adult;Affect;African American;Age;Arkansas;Attention deficit hyperactivity disorder;Behavior;Behavior Disorders;Behavioral;Behavioral Symptoms;Characteristics;Child;Child Development;Child Health;Child Nutrition;Childhood;Communities;Conduct Disorder;Criminal Justice;Data;Databases;Development;Diagnosis;Discipline;Disparity;Education;Educational Status;Eligibility Determination;Enrollment;Ethnic Origin;Event;externalizing behavior;Face;food insecurity;Food Policy;Gender;health care service utilization;health disparity populations;health related quality of life;Household;human capital;Hunger;Impairment;improved;inattention;Incidence;Intervention;juvenile justice system;Lead;Link;longitudinal database;Low income;Medical;medically underserved;Minor;Mississippi;Neighborhoods;Not Hispanic or Latino;novel;nutrition;Oppositional Defiant Disorder;Outcome;Pathway interactions;Performance;Pharmaceutical Preparations;Policies;Population;Prevalence;prevent;Probability;Problem behavior;Prognosis;programs;Public Health;Quasi-experiment;Race;Risk;Rural Population;rurality;Schools;Self-control as a personality trait;service utilization;Socioeconomic Status;Suspensions;Symptoms;System;Testing;underserved community;Variant

PROJECT_TITLE: The Impact of School Meal Delivery on Behavioral Disorders among Children in Health Disparity Populations


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CLEVELAND

ORG_DEPT: PSYCHIATRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Traumatic brain injury (TBI) is an increasingly common cause of neurodegeneration in society today, and the leading environmental cause for Alzheimer's disease (AD)1–5. Mitochondrial fission/fusion activity has been identified as a significant player in neuronal deterioration in several neurodegenerative diseases, including TBI, AD, Huntington's, and Parkinson's diseases, and my preliminary results suggest that this process is also critically involved in both the acute and chronic progression of neurodegeneration after TBI. Here, I propose to fully characterize the role of mitochondrial fission in TBI, and establish its utility as a pharmacologic target for treatment, with the ultimate goal being to expand our understanding of how TBI and AD are connected and facilitate the development of a new neuroprotective treatment for TBI and its resulting acceleration AD.

PI_NAMEs: SRIDHARAN, PREETHY  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Acceleration;Acute;Address;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Animals;Axon;axonal degeneration;behavior test;Behavioral;Biochemical;Bioenergetics;Biological Assay;Blood - brain barrier anatomy;Brain;Brain Concussion;Brain region;career;Chronic;Clinical;Cognitive deficits;Collaborations;Confocal Microscopy;Congo Red;Craniocerebral Trauma;Data;Deposition;Deterioration;Development;Disease;Dynamin;Early treatment;efficacy evaluation;efficacy study;Electron Microscopy;Environmental Risk Factor;Equilibrium;Fostering;Functional disorder;genetic regulatory protein;Genus Hippocampus;Goals;Hippocampus;Histologic;Huntington Disease;Immunohistochemistry;Impairment;Incidence;inhibitor;injured;Injury;insight;Investigation;Life;Link;Measures;Mediating;Mediator;Methods;mild traumatic brain injury;Mitochondria;mitochondrial dysfunction;Modeling;Modification;Monitor;motor deficit;mouse model;multimodal modeling;Mus;Nature;Nerve Degeneration;Neurocognitive;Neurocognitive Deficit;Neurodegenerative Disorders;neurogenesis;neuroinflammation;Neurons;neuroprotection;neuropsychiatry;novel;object recognition;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Peptides;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physicians;Play;Post-Translational Protein Processing;pressure;prevent;Process;Proteins;recruit;Regulation;Reporting;Research Personnel;Risk;Role;Scientist;Senile Plaques;skills;Societies;Stains;Symptoms;System;TBI treatment;Techniques;Testing;Time;Training;Transmission Electron Microscopy;Traumatic Brain Injury

PROJECT_TITLE: The role of mitochondrial fission in neurodegeneration in the leading environmental cause of Alzheimer's disease


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: BURLINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: HIV/AIDS remains an important public health problem. Investigations aimed at understanding how HIV disseminates in infected individuals and how its mode of spread contributes to establishment of latency and pathogenesis may reveal novel targets for intervention.

PI_NAMEs: THALI, MARKUS  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: 3-Dimensional;antiretroviral therapy;Behavior;Binding;Biochemical;Biological Assay;Cell Nucleus;Cells;cellular imaging;Computer Analysis;cytotoxic;Data;design;differential expression;Endowment;Evaluation;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Flow Cytometry;Fostering;Funding;Giant Cells;Goals;Grant;Heterogeneity;HIV;HIV-1;HIV/AIDS;Homeostasis;humanized mouse;imaging study;Immune;Immune response;Impairment;In Vitro;in vivo;Individual;Infection;inflammatory milieu;Integration Host Factors;Interruption;Intervention;intravital imaging;Investigation;Laboratories;live cell imaging;Lymphoid Tissue;Maintenance;Maps;Mediating;Membrane Proteins;migration;Minority;Motility;Natural Killer Cells;novel;particle;Pathogenesis;Phenotype;Physiological;Polyploidy;Population;preservation;prevent;Procedures;Property;Proteome;Proteomics;Public Health;Publishing;quantitative imaging;recruit;resilience;Resistance;Resolution;Role;Secure;Surface;T-Lymphocyte;Testing;Therapeutic;tool;transmission process;Universities;Viral;viral transmission;Virus;Work

PROJECT_TITLE: Multiscale analysis of HIV-1-induced small T cell syncytia

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed studies aim to reveal new molecular and cellular mechanisms for learning, memory and synaptic plasticity involving the role of a specific biochemical pathway controlling protein synthesis and the process of cholinergic neuromodulation. The knowledge gained may uncover new molecular targets to consider for therapy development for a wide range of human disorders, including aging and memory-related conditions. Mechanisms revealed specifically in the basal ganglia circuitry may further provide insights helpful for a range of conditions that include Parkinson's disease, dystonia, Tourette's syndrome, addiction, Obsessive compulsive disorder and autism.

PI_NAMEs: CALAKOS, NICOLE  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acetylcholine;Adaptive Behaviors;addiction;Affect;Aging;autism spectrum disorder;Basal Ganglia;Behavior;Behavioral;behavioral plasticity;Biochemical Pathway;Biological;biological adaptation to stress;Brain;calmodulin-dependent protein kinase II;Cells;Cellular Stress;Chemosensitization;cholinergic;cholinergic neuron;Code;Cognitive;Color;Corpus striatum structure;Data;Dedications;Dementia;Disease;Dopamine;DRD2 gene;Dystonia;EIF-2alpha;Endowment;Eukaryotic Initiation Factors;experience;experimental study;Foundations;G Protein-Coupled Receptor Signaling;Genes;Genetic;genetic approach;Genetic Techniques;Gilles de la Tourette syndrome;Health;Human;insight;Intellectual functioning disability;Interneurons;Knowledge;Laboratories;learned behavior;Learning;Mediating;Memory;Memory impairment;Methodology;Modality;Modeling;Molecular;Molecular Genetics;Molecular Target;Names;Neuromodulator;Neurons;neuroregulation;Obsessive-Compulsive Disorder;Outcome;Parkinson Disease;Pathway interactions;Peptide Initiation Factors;permissiveness;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Physiology;Process;Protein Biosynthesis;Proteins;Proteomics;proteostasis;real time monitoring;Regulation;Reporter;Reporting;Resolution;response;Role;Series;Signal Transduction;Site;small molecule;spatiotemporal;stressor;Synapses;synaptic depression;Synaptic plasticity;targeted treatment;Testing;therapy development;Transcript;Translations;Traumatic Brain Injury;Validation;Viral;Visit;Work

PROJECT_TITLE: Significance of Protein Synthesis by the Integrated Stress Response in Neuromodulatory Neurons for Adaptive Behavior and Synaptic Plasticity

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Mental Illness;Neurosciences

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Working memory is the ability to think about information that is not present in the environment and to use it guide behavior. Its impairment is characteristic of many psychopathologies and psychiatric syndromes, including attention deficit hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia. These experiments will study how the brain controls working memory, and may provide results that could be useful for developing diagnostic tools and treatments.

PI_NAMEs: POSTLE, BRADLEY R (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Algorithms;Anterior;Attention deficit hyperactivity disorder;Basal Ganglia;base;Behavior;Behavior Control;Behavioral;Behavioral trial;Brain;brain control;Brain region;Characteristics;Cognition;cognitive control;cognitive system;Computer Simulation;Data;Data Set;diagnostic tool;Electroencephalography;Elements;Environment;Excision;experimental study;flexibility;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;Goals;Human;Impairment;indexing;Insula of Reil;Investigation;Laboratories;Learning;Left;Magnetic Resonance Imaging;Major Depressive Disorder;Modeling;neural;novel;operation;paired stimuli;Parameter Estimation;Pattern;Problem Solving;Process;Psychological reinforcement;Psychopathology;recruit;recurrent neural network;Research;Schizophrenia;sensory input;Short-Term Memory;Signal Transduction;Site;Source;stimulus processing;Syndrome;System;Testing;Training;Transcranial magnetic stimulation;trial comparing;Visual;Visual Perception;visual stimulus;Work

PROJECT_TITLE: Controlling the Contents of Working Memory

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Juvenile myelomonocytic leukemia (JMML), a fatal childhood blood cancer, has limited therapeutic options. Relapse remains the main cause of treatment failure, most likely due to the persistence of leukemic stem cells, a small population of self-renewing precursor cells that is responsible for the long-term maintenance of leukemia growth and is also a major source of drug resistance. The project proposed in this application explores a novel strategy to eradicate these tumor initiating cells in a subset of JMML caused by genetic mutations in Ptpn11.

PI_NAMEs: QU, CHENG-KUI  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Acceleration;Address;Adolescent;Allogenic;anti-cancer research;Anti-malarials;Area;atovaquone;cancer therapy;Cell Death Induction;Cell Separation;Cells;Characteristics;Childhood;Clinical;Clinical Research;Development;Diagnosis;DNA Sequence Alteration;Drug resistance;early childhood;Experimental Leukemia;FDA approved;Funding Opportunities;Growth;Hematologic Neoplasms;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic stem cells;Hematopoietic System;Heterozygote;Hyperactivity;Impairment;inhibitor;Juvenile Myelomonocytic Leukemia;juvenile myelomonocytic leukemia cell;Knock-in Mouse;Laboratories;leukemia;leukemic stem cell;Maintenance;Malignant Neoplasms;Methodology;Modeling;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Myeloproliferative disease;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Outcome;Pathogenesis;Pathway interactions;Patient Care;Patients;Penetrance;Pharmaceutical Preparations;pharmacologic;Phase;Population;pre-clinical;precursor cell;Prevention;Prognosis;Property;Protein Dephosphorylation;Protein Tyrosine Phosphatase;Proteins;Relapse;Research;response;Risk;Role;self-renewal;Signal Pathway;Signal Transduction;Signaling Protein;Source;standard of care;Stem cell transplant;stem cells;Techniques;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapeutically effective;Transplantation;Treatment Failure;tumor eradication;tumor initiation;Tyrosine Phosphorylation;Work;Xenograft Model

PROJECT_TITLE: Eradicating leukemic stem cells in juvenile myelomonocytic leukemia


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Neurosciences;Rehabilitation;Stroke

ORG_CITY: BOSTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE Approximately 100,000 individuals suffer from aphasia each year. The academy of aphasia is an organization of clinicians, scientists and practitioners who study this communication disorder and develop interventions to treat individuals with aphasia. The members comprise a very interdisciplinary group of linguists, psychologists, speech and language clinicians, neurologists and neuroscientists. The annual academy of aphasia meeting is the premier venue to share state of the art methodologies for application in the study of aphasia to improve the research in the development of diagnosis and treatment approaches to alleviate aphasia. This conference is also the ideal venue to educate and train the next generation of aphasia researchers who are well trained from a theoretical, technical and clinical standpoint and are committed to expand the impact of research in aphasia.

PI_NAMEs: KIRAN, SWATHI  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Academia;Academy;Acquired Language Disorders;Address;Aging;Aphasia;Basic Science;Behavioral;bilingualism;Brain;Brain imaging;Caliber;career;career networking;Chicago;Clinical;Communication;Communication impairment;Computer Models;Continuing Education;Country;COVID-19 pandemic;Development;Diagnosis;Discipline;Disease;Educational workshop;Ensure;Equity;experience;explicit bias;Feedback;Fellowship;follow-up;Fostering;Foundations;frontier;Funding;Goals;Grant;Hour;Hybrids;implicit bias;improved;Individual;Inequality;Inequity;Interdisciplinary Study;International;Intervention;Journals;Language;Language Disorders;language processing;Learning;Lesion;lexical;Linguistics;Manuscripts;Maps;meetings;member;Mentors;Mentorship;Methodology;Minority;National Institute on Deafness and Other Communication Disorders;Nature;Neurodegenerative Disorders;neuroimaging;Neurologist;Neurology;Neuronal Plasticity;Neurosciences;next generation;Nonprofit Organizations;novel strategies;Orthography;Outcome;Paper;Pathologist;Persons;phonology;Population;Positioning Attribute;post stroke;Postdoctoral Fellow;Process;programs;Psychologist;Psychology;Publications;Publishing;Quality of life;Recovery;Rehabilitation therapy;Research;Research Personnel;Science;Scientist;Secure;semantic processing;social culture;Speech;Speech Pathologist;Structure;Student Selections;Students;success;symposium;Symptoms;syntax;Talents;Techniques;tenure track;Textiles;Training;Travel;Underrepresented Minority;Woman;Work;Writing

PROJECT_TITLE: Academy of Aphasia Research and Training Symposium


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Prevention;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: VALHALLA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NEW YORK MEDICAL COLLEGE

ORG_STATE: NY

PHR: Narrative Schizophrenia is a highly heritable neurodevelopmental disorder, but the mechanisms behind how schizophrenia genetic risk loci function is not clear. Cortical interneurons are substantially affected in schizophrenia and enriched for schizophrenia heritability during development. The proposed study is aimed at identifying schizophrenia risk loci that are active in these neurons during development, which will provide insights on the developmental mechanisms of SCZ risks, and help identify novel therapeutic targets.

PI_NAMEs: CHUNG, SANGMI  (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;ATAC-seq;Autopsy;Biological;Brain;brain cell;brain tissue;cell type;Cells;ChIP-seq;Chromatin;Chromosomes;Code;cohort;Complement;Complex;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Data Set;Development;Developmental Process;differentiation in vitro;Disease;Distal;Early identification;Embryo;Embryonic Development;fetal;Fetal Development;Gene Expression;Gene Expression Profile;gene regulatory network;Generations;Genes;Genetic;genetic makeup;Genetic Risk;Genetic study;Genome;genome wide association study;genome-wide;Genomics;Genotype;Glean;Goals;Heritability;Human;human fetal brain;In Vitro;in vivo;induced pluripotent stem cell;insight;Interneurons;Libraries;Maps;Medial;Methods;migration;Mus;Neurodevelopmental Disorder;Neurons;new therapeutic target;Parvalbumins;Pathologic;Pathway interactions;Patients;pluripotent stem cell differentiation;Population;Procedures;Qualifying;Quantitative Trait Loci;Regulation;Resolution;risk variant;Role;Schizophrenia;schizophrenia risk;Somatostatin;Synapses;Testing;Time;Tissues;Training;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Transplantation;Untranslated RNA;Validation;Variant;Weight;Work

PROJECT_TITLE: Common schizophrenia variants functioning in developmental human cortical interneurons

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: Aurora

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Three-dimensional brightfield and bioluminescent microscopy has provided meaningful insights into biology with small animals, parasites, and large bacteria. Existing tools that perform this type of imaging cost between thousands and tens of thousands of US dollars, which limits the research to well-resourced laboratories. We propose to use 3D printed parts, laser cut acrylic, and commercially available components to create tomographic microscope of this type with a smartphone for less than $50, which would provide this type of microscopy to less-resourced laboratories and to remote locations.

PI_NAMEs: DWORK, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TITLE: Three-dimensional, Portable, Inexpensive, and Reusable Tomographic Microscopy


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Infectious Diseases;Precision Medicine;Radiation Oncology;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Patients with locally-advanced cervical cancer with lymph node metastases exhibit poor prognosis despite the current standard of care therapy with chemotherapy and radiation. There is thus a critical need to develop new therapeutic strategies for patients with high-risk cervical cancer and to identify biomarkers that could predict which patients are more likely to benefit. The current proposal will take advantage of tumor and blood samples collected from high-risk cervical cancer patients treated on an NCI-funded clinical trial of immunotherapy combined with chemotherapy and radiation to determine optimal sequencing of immunotherapy and radiation and to identify the patients that do or do not benefit from this approach.

PI_NAMEs: ZAMARIN, DMITRIY  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Address;Affect;Aftercare;anti-tumor immune response;Antigen-Presenting Cells;arm;Bioinformatics;Biological Assay;Biological Markers;biomarker identification;Biopsy;Blood;Blood specimen;burden of illness;Cancer Patient;Cells;Cessation of life;chemoradiation;Chemotherapy and/or radiation;Cisplatin;Clinical;Clinical Trials;Clonality;Collection;Combination Drug Therapy;Combination immunotherapy;Data;digital;Disease;Disease Marker;Disease-Free Survival;DNA;DNA copy number;draining lymph node;Drug Targeting;Early identification;Evolution;Exhibits;experience;Financial Hardship;Fluorescence Microscopy;follow-up;Freezing;Funding;Genetic;Genomics;Goals;Head and Neck Cancer;high risk;Human papilloma virus infection;Human Papillomavirus;immune checkpoint blockade;Immunofluorescence Microscopy;Immunogenomics;Immunotherapy;immunotherapy clinical trials;improved;In complete remission;Knowledge;Maintenance;Maintenance Therapy;Malignant neoplasm of cervix uteri;Measures;Metastatic Neoplasm to Lymph Nodes;Molecular Profiling;Morbidity - disease rate;mortality;neoplastic cell;novel therapeutic intervention;Outcome;outcome prediction;Paraaortic;partial response;Pathologic;Patient Selection;patient stratification;Patient-Focused Outcomes;Patients;PD-1 inhibitors;PDL1 inhibitors;pembrolizumab;Peripheral;peripheral blood;PET/CT scan;Phenotype;Plasma;Positron-Emission Tomography;predicting response;predictive marker;Predictive Value;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;prospective;Radiation;Radiation therapy;radiological imaging;Randomized;Recurrence;Relapse;response;Risk;risk stratification;Source;spatial relationship;Specimen;standard of care;T cell receptor repertoire sequencing;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Techniques;Tissues;Toxic effect;treatment response;tumor;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;United States;uptake;Viral;Woman

PROJECT_TITLE: Immunogenomic predictors of outcomes in patients with locally advanced cervical cancer treated with immunotherapy and chemoradiation

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Patient Safety

ORG_CITY: IRVINE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PUBLIC HEALTH RELEVANCE: Ischemic heart disease is a leading cause of mortality and morbidity. This project proposes to test a new noninvasive technique that can accurately assess the functional severity of ischemic heart disease in patients, with the goal to reduce unnecessary invasive studies, increase patient safety, and reduce related healthcare costs.

PI_NAMEs: MOLLOI, SABEE  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: accurate diagnosis;Anatomy;Angiography;Arrhythmia;Blood flow;Blood Vessels;Calcium;Cardiac;Cardiac Catheterization Procedures;cardiovascular risk factor;Catheterization;Catheters;Cause of Death;Claustrophobias;Clinical;Clinical assessments;clinical implementation;Complex;Coronary;Coronary Angiography;Coronary Arteriosclerosis;Coronary artery;coronary artery calcification;coronary calcium scoring;Coronary Circulation;coronary computed tomography angiography;Coronary heart disease;coronary plaque;cost;Diagnosis;Diffuse;Disease;Dose;Enrollment;Evaluation;Event;Goals;Health Care Costs;Healthcare Systems;Heart failure;high risk;Ischemia;Laboratories;Lesion;low dose computed tomography;Low Dose Radiation;Magnetic Resonance;Measurement;Measures;Methods;Morbidity - disease rate;mortality;mortality risk;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardial perfusion;non-invasive imaging;Normal Range;novel;Outcome;patient safety;Patients;Perfusion;Physiological;Physiology;Positron-Emission Tomography;Pre-Clinical Model;Procedures;Prospective Studies;public health relevance;Radiation Dose Unit;recruit;Reference Standards;Reference Values;Reporting;Resolution;Rest;Risk;Safety;Severities;Stress;Stress Tests;successful intervention;sudden cardiac death;Symptoms;Techniques;Testing;Time;tool;Validation;X-Ray Computed Tomography

PROJECT_TITLE: Quantitative coronary flow capacity with low-dose CT for ischemia but no obstructive coronary artery disease

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Neurosciences

ORG_CITY: MEMPHIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF MEMPHIS

ORG_STATE: TN

PHR: PROJECT NARRATIVE Stuttering profoundly impacts quality of life, mental health, and social, educational, and occupational success for millions of Americans and approximately 55 million worldwide. The proposed research addresses this critical public health need by contributing fundamental knowledge about the role of attention in core emotional features of stuttering. Through a multi-paradigm approach that synthesizes behavioral and eye-tracking indices of attention bias, the project examines associations between threat-related patterns of attention allocation and stuttering, providing a foundation for the development of novel interventions designed to target emotional responses to stuttering by reshaping underlying attention patterns.

PI_NAMEs: EICHORN, NAOMI  (contact)

PROJECT_TERMS: Address;Adult;adverse outcome;Affect;American;Anxiety;Anxiety Disorders;Attention;attentional bias;attentional control;Attitude;Automobile Driving;Behavior;Behavioral;Belief;Categories;Characteristics;Child;Clinical;Cognitive;Data;Detection;Development;Disease;Education;Emotional;Emotions;Etiology;experience;Foundations;Fright;Future;Goals;high risk;indexing;Individual;Individual Differences;individual response;information processing;innovation;Intervention;Intervention Studies;Joints;Knowledge;Life Experience;Link;Literature;Lived experience;Maintenance;Measures;Mediating;Mediation;Mental Health;Methodology;Minor;Mission;Modeling;Modification;National Institute on Deafness and Other Communication Disorders;Neurodevelopmental Disorder;novel;novel strategies;Occupational;Outcome;Pattern;peer;Population;Process;psychologic;psychosocial;Public Health;Quality of life;Reaction;Reaction Time;Research;Research Design;response;Risk;Risk Factors;Role;Sampling;Scanning;selective attention;Shame;Shapes;social;Social isolation;sound;Specificity;stem;Stimulus;Stuttering;success;Surface;Symptoms;Techniques;Temperament;theories;therapy design;Thinking;Time;Training;Translational Research;vigilance;Visual attention;visual tracking;Work

PROJECT_TITLE: Information processing biases in adults who stutter: Behavioral and eye-tracking indices of threat-related attention allocation


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pain Research;Patient Safety;Precision Medicine;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative Refractive eye surgery, including photorefractive keratectomy (PRK) and laser-assisted in-situ keratomileusis (LASIK), leads to persistent pain in some individuals that negatively and significantly impacts quality of life. Our studies will examine whether proteins in tear fluids collected before and after surgery can identify a biomarker signature that is predictive and diagnostic of persistent corneal pain after eye surgery.

PI_NAMEs: AICHER, SUE A (contact);GALOR, ANAT

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: Ablation;Acute Pain;Age;Algorithms;American;analytical method;antinociception;Bathing;Biological;Biological Assay;Biological Markers;biomarker signature;biomarker validation;Biometry;Categories;Clinical;Collection;combat;Consensus;Cornea;corneal ablation;corneal epithelium;Corneal Injury;Corneal pain;Detection;Development;Diagnostic;diagnostic biomarker;Disease;Disease Progression;Excision;experience;Eye;Eye diseases;eye dryness;Feeling suicidal;Future;Goals;Hour;improved;In Situ;Individual;keratomileusis;Knowledge;Lasers;Link;Lipids;Liquid substance;Mass Spectrum Analysis;Measures;Mental Health;Methods;Morbidity - disease rate;Nerve;Nociception;Non-Steroidal Anti-Inflammatory Agents;Normal Range;Numeric Rating Scale;ocular pain;Operative Surgical Procedures;Ophthalmologic Surgical Procedures;Opioid;Oral;Outcome;Pain;Pain management;Pain Measurement;pain reduction;pain score;Participant;patient population;patient screening;patient stratification;Patients;Persistent pain;Phase;Photorefractive Keratectomy;Population;Postoperative Pain;predictive marker;Probability;Procedures;prognostic;Prognostic Marker;prognostication;Protein Analysis;protein biomarkers;Proteins;Proteomics;Quality of life;recruit;Refractive Errors;Reporting;Reproducibility;resilience;response;Risk;Sampling;Sensory Nerve Endings;sex;Smoking Status;Source;Suicide;Surface;surgical pain;tear proteins;Therapeutic;Treatment Efficacy;United States;Validation;Variant;Vision;Visit;Vulnerable Populations;Water;Work

PROJECT_TITLE: Tear protein biomarkers of refractive surgery pain

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Lupus;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: SHERMAN OAKS

ORG_NAME: TRETHERA CORPORATION

PHR: PROJECT NARRATIVE Lupus is a debilitating autoimmune disease that damages vital organs and is associated with significant morbidity and mortality. Current therapies can be effective but work on only a subset of patients and suffer from significant side effects, and new therapies are urgently needed. Here we test whether a newly developed inhibitor of the enzyme deoxycytidine kinase can limit disease in a mouse model of lupus.

PI_NAMEs: SCHULTZ, KENNETH  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Adverse event;Affect;Alopecia;Ames Assay;anti-dsDNA antibodies;Arthritis;Autoimmune Diseases;Autoimmune Hepatitis;autoreactive B cell;autoreactivity;B Cell Proliferation;B-Lymphocytes;Biological Markers;Blood Urea Nitrogen;Body System;Brain;Cancer Patient;CD4 Positive T Lymphocytes;cell type;Cells;Central Nervous System;Chronic;Clinical;Data;Deoxycytidine;Deoxycytidine Kinase;Deoxyribonucleosides;Deoxyribonucleotides;Dermatitis;Development;Disease;disease heterogeneity;Disease Progression;DNA biosynthesis;Dose;Drug Targeting;effective therapy;Enzyme Inhibitor Drugs;Enzymes;Experimental Autoimmune Encephalomyelitis;extracellular;Fever;Flare;Glomerulonephritis;Grant;Human;Hydroxychloroquine;Image;Immune;immune cell infiltrate;Immune system;Impairment;in vivo;inhibitor;Kidney;Lead;Life Expectancy;Link;Lung;Lupus;lymph nodes;lymphadenopathy;Lymphocyte;Lymphocyte Activation;lymphoid organ;Lymphoid Tissue;Malignant Neoplasms;Measurable;Measurement;Measures;Metabolism;Modeling;Morbidity - disease rate;mortality;mouse model;Multiple Sclerosis;Mus;Myocardial Infarction;novel;novel therapeutics;nucleoside inhibitor;Onset of illness;Organ;Pathway interactions;patient biomarkers;patient stratification;patient subsets;Patients;PET/CT scan;Pharmaceutical Preparations;pharmacodynamic biomarker;pharmacokinetics and pharmacodynamics;Phase;phase 2 study;Phase I Clinical Trials;Phenotype;Plasma;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Proliferating;Property;prophylactic;Proteinuria;Publishing;radiotracer;Regulatory T-Lymphocyte;Reporting;response;Role;Serious Adverse Event;side effect;Small Business Technology Transfer Research;small molecule;small molecule inhibitor;Solid Neoplasm;Spleen;Stable Disease;Stroke;success;Symptoms;systemic autoimmune disease;Systemic Lupus Erythematosus;T-Cell Proliferation;T-Lymphocyte;targeted biomarker;Testing;Therapeutic;Time;Tissues;Treatment Efficacy;Work

PROJECT_TITLE: Development of a Novel, Targeted Small Molecule Inhibitor of the Nucleoside Salvage Pathway to Treat Systemic Lupus Erythematosus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(10)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Pregnancy;Prevention;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative The COVID-19 pandemic is an unprecedented public health crisis. Pregnant women and their fetuses may be particularly vulnerable to the long-term effects of SARS-CoV-2 infection (the viral infection responsible for COVID-19). This study aims to clarify the long-term effects of SARS-CoV-2 infection during pregnancy on women’s and children’s health, to inform health systems of the need to identify and treat high-risk women and children.

PI_NAMEs: AVALOS, LYNDSAY AMMON;HEDDERSON, MONIQUE MARIE (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 3 year old;Anxiety;Biological;Birth;Body mass index;California;Cardiac;cardiometabolism;Cardiovascular system;Chest Pain;Child;Child Health;Chronic stress;Clinical;clinical diagnosis;cohort;Communication;comorbidity;comparison group;COVID-19;COVID-19 diagnosis;COVID-19 impact;COVID-19 pandemic;COVID-19 susceptibility;Data;depressive symptoms;Diabetes Mellitus;Diagnosis;Disease;Early Intervention;Electronic Health Record;Epidemiology;Ethnic Origin;Event;Exposure to;Fetus;Future;Gestational Age;Growth;Growth and Development function;Health;health goals;Health system;Healthcare;Healthcare Systems;high risk;High Risk Woman;Hospitalization;Hypertension;Immune response;Immunity;Impairment;Individual;Infection;interest;Joints;Knowledge;long term consequences of COVID-19;Long-Term Effects;Longterm Follow-up;maternal morbidity;Mental Depression;Modification;Monitor;Morbidity - disease rate;Mothers;Motor;neurodevelopment;Neurodevelopmental Impairment;Neurologic Effect;neuropsychiatry;Organ;Outcome;pandemic disease;Parents;Pathway interactions;Patient Self-Report;perinatal outcomes;Persons;Population;post pregnancy;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;Post-Traumatic Stress Disorders;Postpartum Period;Pregnancy;Pregnant Women;Premature Birth;prenatal exposure;prepregnancy;Problem Solving;Public Health;Quality of life;Race;recruit;Reporting;Research;Risk;Risk Factors;Sampling;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.1.7;SARS-CoV-2 B.1.351;SARS-CoV-2 B.1.617.2;SARS-CoV-2 exposure;SARS-CoV-2 infection;SARS-CoV-2 infection history;SARS-CoV-2 positive;SARS-CoV-2 variant;Self Assessment;severe maternal morbidity;Severities;skills;Speech Disorders;Surveys;Symptoms;systemic inflammatory response;Testing;Time;unvaccinated;Vaccination;Variant;venous thromboembolism;Virus;Virus Diseases;Woman;women of color;women's outcomes

PROJECT_TITLE: Long term adverse health outcomes for women and children following SARS-CoV-2 infection during pregnancy

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Lymphatic Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  The lymphatic system is essential for tissue fluid homeostasis, immune surveillance and fat absorption among others. However, the lymphatic system has been inadequately studied in the liver and its role in liver physiology and pathophysiology is poorly understood. The goal of this proposed research is to advance our understanding of the hepatic lymphatic system.

PI_NAMEs: IWAKIRI, YASUKO  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: 3-Dimensional;Ablation;absorption;Area;Ascites;bile duct;Carbon Tetrachloride;Cell Separation;Cells;Cirrhosis;Data;Development;Disease;Disease Progression;Fatty acid glycerol esters;Fibronectins;Fluid Balance;Fluorescence Microscopy;Functional disorder;Goals;Health;Hepatic;Hepatic Fibrogenesis;Immunologic Surveillance;Inflammation;Inflammatory Response;Inhalation;Integrins;KDR gene;Kupffer Cells;Ligation;Light;Liver;liver development;Liver Fibrosis;Lymph;Lymphangiogenesis;Lymphatic;Lymphatic Endothelial Cells;Lymphatic System;lymphatic vessel;Macrophage;Modeling;Mus;Nerve;Nervous System;Neurotransmitters;Operative Surgical Procedures;Organ;overexpression;Patients;Phenotype;Physiology;Play;Portal Hypertension;Portal vein structure;Prevention;Preventive;Production;recruit;Regulation;Research;response;Role;Schwann Cells;Signal Transduction;single-cell RNA sequencing;Site;Source;spatiotemporal;Surgical Models;Testing;Therapeutic;Tissues;treatment effect;vascular contributions;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factor Receptor-3;vessel regression;Visual;Visualization

PROJECT_TITLE: Lymphatics in the liver

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(04)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Hepatitis - C;Infectious Diseases;Liver Disease;Orphan Drug;Pediatric;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Current treatment and prevention of HIV, tuberculosis, and viral hepatitis requires taking pills every day for long periods of time. LEAP encourages the development of long-acting injectable and implantable drugs by providing access to scientific, pharmaceutical, regulatory, and community-based experts and services. This could results in the replacement of daily oral regimens with products given as infrequently as once per year.

PI_NAMEs: FLEXNER, CHARLES W. (contact)

PROGRAM_OFFICER_NAME: PROTOPOPOVA, MARINA

PROJECT_TERMS: Acceleration;Adolescent;Affect;AIDS prevention;animal data;Anti-Infective Agents;Anti-Retroviral Agents;Area;Award;Benchmarking;biodegradable polymer;Capsid;Characteristics;Child;clinical development;Clinical Trials;Communication;Communities;Consultations;Development;Devices;Disease;Dose;drug action;Drug Approval;Drug Combinations;Drug Delivery Systems;Drug Exposure;Drug Implants;Drug Interactions;drug resistance development;Drug Screening;Drug Targeting;Ensure;Epidemic;Failure;Formulation;Funding Mechanisms;Future;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;HIV;Human;Hydrogels;Implant;improved;in silico;In Vitro;Infection;Infection prevention;Infrastructure;inhibitor;Injectable;Intramuscular Injections;Knowledge;Laboratories;Malaria;Modeling;models and simulation;Monoclonal Antibodies;National Institute of Allergy and Infectious Disease;Needles;new chemical entity;new technology;next generation;novel;novel strategies;novel therapeutics;open source;Oral;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacokinetic model;pharmacologic;Pharmacologic Substance;Phase;Physiological;pill;preclinical development;predictive modeling;Pregnant Women;prevent;Prevention;Process;product development;programs;Property;R24;Regimen;Research;Resource-limited setting;Resources;Risk;Seminal;Services;symposium;Technology;Testing;Time;Toxic effect;Toxicology;trait;Translations;Tuberculosis;Viral;Viral hepatitis;Vulnerable Populations;web site;Work;working group

PROJECT_TITLE: The Long-Acting/Extended Release Antiretroviral Resource Program (LEAP)


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Human Genome;Kidney Disease;Lupus;Prevention

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

PHR: PROJECT NARRATIVE Systemic lupus erythematosus is a complex autoimmune disease that affects up to 1.5 million Americans; up to half of people with lupus have a serious kidney disease called lupus nephritis. Though how doctors treat lupus nephritis has improved over the years, few drugs to treat lupus nephritis exist and the underlying mechanisms of disease are still being discovered. Here, we propose a cutting-edge method to identify genes that affect one new mechanism of lupus nephritis involving a specialized white blood cell called patrolling monocytes with the goal to not only learn new information about how lupus nephritis develops, but to also identify new proteins that may serve as targets for future therapeutics.

PI_NAMEs: HAMERMAN, JESSICA A (contact);RAY, JOHN PHILIP

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Ablation;Affect;African American population;American;Asian population;Autoimmune;Autoimmune Diseases;B-Lymphocytes;belimumab;Bioinformatics;cell type;Cells;chronic autoimmune disease;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR screen;CRISPR/Cas technology;Data;Diagnosis;Disease;disorder risk;Disproportionately impacts women;End stage renal failure;experimental study;Exploratory/Developmental Grant;FCGR2B gene;Future;Genes;Genetic Risk;genetic variant;genome wide association study;genomic locus;Genomics;Glomerular Capillary;Glomerulonephritis;Goals;Haplotypes;Hematopoietic stem cells;high reward;high risk;Hispanic Populations;Human;Human Genetics;Immune;improved;in vivo;Individual;innate immune mechanisms;innovation;ITGAM gene;Kidney;Kidney Diseases;knockout gene;Learning;Leukocytes;Lupus;Lupus Nephritis;lupus prone mice;lupus-like;Macrophage;Mediating;Methods;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Myeloid Cells;Nephritis;new therapeutic target;novel;novel therapeutic intervention;Organ;Pathogenicity;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;prevent;Process;Proteins;recruit;Research Institute;Risk;risk variant;Role;Source;systemic autoimmune disease;Systemic Lupus Erythematosus;T-Lymphocyte;Testing;Therapeutic;Therapeutically Targetable;TLR7 gene;transcription factor;Validation;Variant

PROJECT_TITLE: Identifying autoimmune associated genes in patrolling monocytes that promote lupus nephritis

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Patient Safety;Precision Medicine

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The goal of this proposal is to improve our understanding of how genetic and non-genetic factors affect drug metabolism and drug response in patients from understudied ethnic backgrounds. This research is important to individualize drug treatment for patients to maximize beneficial drug effects (efficacy) and minimize serious side effects (toxicity). This work will lay the foundation needed to implement precision medicine for ethnically diverse patient populations to achieve the right drug at the right dose for the right patient at the right time.

PI_NAMEs: JACKSON, KLARISSA D (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Affect;Age;Award;Biological Markers;Clinical;Cytochrome P450;Data;Dedications;Dose;drug disposition;Drug Interactions;Drug Kinetics;drug metabolism;drug response prediction;Enzymes;Epigenetic Process;epigenomics;ethnic diversity;Ethnic Origin;Ethnic Population;European;European ancestry;Foundations;Genes;Genetic;Genetic Markers;genetic variant;Genotype;Germ Lines;Goals;implementation barriers;improved;Individual;insight;inter-individual variation;Investigation;Investments;Laboratories;Mentors;metabolic abnormality assessment;metabolomics;multiple omics;next generation;non-genetic;patient population;Patients;Pharmaceutical Preparations;Pharmacogenetics;Pharmacogenomics;pharmacokinetic model;Pharmacotherapy;Phenotype;phenotypic biomarker;physiologically based pharmacokinetics;Population;Population Heterogeneity;precision medicine;Precision Medicine Initiative;predictive modeling;programs;Proteomics;Research;Research Personnel;response;Scientist;sex;side effect;Testing;Time;Toxic effect;Variant;Vision;Work

PROJECT_TITLE: Interindividual Variability in Drug Metabolism in Ethnically Diverse Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Social Determinants of Health;Telehealth

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE In partnership with Mental Health America (MHA), a non-profit mental health advocacy group offering free, evidence-based screenings and self-guided digital mental health (DMH) resources, the proposed research aims to identify and test tailored strategies to optimize sexual and gender minority (SGM) consumers' engagement with MHA's DMH content. The use of an existing DMH infrastructure, a large, naturalistic sample, and methods such as supervised machine learning, human-centered design approaches, and micro-randomized trial design provide an innovative approach to optimize DMH engagement outcomes among SGM consumers. This study addresses several key objectives outlined within Goal 4 of the NIMH Strategic Plan—to strengthen the public health impact of NIMH-supported research—including improving access, delivery, and quality of mental health care (Objective 4.1) and promoting mental health equity for SGM populations (Objective 4.3).

PI_NAMEs: ROMANELLI, MEGHAN  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Address;Adult;Advocacy;Affective;analytical method;Anxiety;barrier to care;Behavioral;big data management;care preference;career;Caring;Characteristics;cisgender;Cognitive;Communities;Data Analyses;Data Analytics;data integration;design;Development;digital intervention;digital mental health;Discrimination;Distal;Ethnic Origin;Evaluation;evidence base;Expectancy;experience;Experimental Designs;feasibility testing;Feedback;Focus Groups;Funding;Future;Gender Identity;gender minority group;gender minority health;gender minority youth;Goals;Health;Health behavior change;health care availability;health disparity;health equity;health equity promotion;health goals;Health Resources;Health Services;Health Services Accessibility;Health Services Research;Healthcare;help-seeking behavior;Heterogeneity;Heterosexuals;human centered design;Improve Access;improved;Informatics;Infrastructure;innovation;insight;Internet;Intervention;K-Series Research Career Programs;marginalized population;member;Mental Depression;Mental Health;Mental health promotion;Mental Health Services;Metadata;Methodology;Methods;Modeling;Names;National Institute of Mental Health;Outcome;Pattern;peer;Personal Satisfaction;Population;Positioning Attribute;preference;Principal Investigator;Process;professor;prototype;psychoeducation;Public Health;Race;randomized trial;Reporting;Research;Research Support;Route;Safety;Sampling;screening;Self Direction;self reliance;service delivery;Services;Sex Orientation;Sexual and Gender Minorities;sexual identity;sexual minority group;sexual minority youth;Shapes;Social Work;Source;Strategic Planning;Subgroup;supervised learning;Support Groups;Symptoms;Technology;Testing;theories;Therapeutic;tool;Training;trial design;Universities;Washington

PROJECT_TITLE: Optimizing Engagement in Digital Mental Health Services among Sexual and Gender Minority Consumers

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Batten Disease;Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: Our goal is to find new ways to treat CLN1 disease or Infantile Neuronal Ceroid Lipofuscinosis (or Infantile Batten disease), a fatal neurodegenerative disorder of childhood. Based on the therapeutic advances we have made in CLN1 mice, we now propose scaling up our AAV9-mediated gene therapy approach in a CRISPR/Cas9 generated sheep model of this disorder. Defining the affected regions of the CNS, the neurologic consequences, and optimizing vector delivery routes will allow us to test the efficacy, dosing and safety of gene therapy in CLN1 R151X sheep in order to define a strategy that is clinically translatable.

PI_NAMEs: COOPER, JONATHAN D (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;adeno-associated virus 9 delivery;Affect;Animals;Biodistribution;Brain;brain magnetic resonance imaging;Brain region;canine model;Canis familiaris;Central Nervous System;cerebral atrophy;Characteristics;Child;Childhood;Clinic;Clinical;clinical translation;Clinical Treatment;Clinical Trials;CLN1 gene;CLN2 gene;Cognitive;cognitive function;Complex;CRISPR/Cas technology;Data;Data Correlations;delivery vehicle;design;Development;Disease;disease model;disease phenotype;Disease Progression;disease-causing mutation;Dose;early onset;effective therapy;efficacy evaluation;efficacy testing;end stage disease;enzyme activity;Enzymes;experience;FDA approved;Gene Delivery;gene therapy;genome editing;Goals;Histologic;Human;human model;Image;Immune response;improved;in vivo;infancy;Infantile neuronal ceroid lipofuscinosis;Inherited;Injections;Knowledge;Life;life span;Magnetic Resonance Imaging;Mediating;mouse model;Mus;Nerve Degeneration;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;Neurologic;Neuronal Ceroid-Lipofuscinosis;neuropathology;novel;Organ;Outcome;Outcome Measure;Pathogenesis;Pathology;Performance;Phenotype;Positioning Attribute;Program Development;Publishing;Radiology Specialty;Regimen;research clinical testing;response;Route;Safety;scale up;Serotyping;Sheep;sheep model;Site;Spielmeyer-Vogt Disease;Spinal Cord;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapy outcome;thioesterase PPT1 gene product;Time;Translating;Treatment Efficacy;Treatment outcome;vector;Viral;Viral Genes;Viral Vector;Visceral;Work

PROJECT_TITLE: Characterizing and testing the efficacy of AAV-mediated gene therapy in a sheep model of CLN1 disease.

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences;Nutrition;Patient Safety;Pediatric

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: NARRATIVE Impairments in eating, dysfunctional swallowing, and aerodigestive symptoms in infants are a notable public health concern and contribute to significant socio-economic burdens such as prolonged hospital stays, neuro- developmental delays, or death and parental suffering. This proposal addresses a critical need in neonatal gas- troenterology by examining unique swallowing mechanisms, and defining the basis for preventative and correc- tive therapies by employing new translational research initiatives. Our research aligns closely with NIDDK's mis- sion to conduct and support medical research on digestive diseases and nutritional disorders that will impact the quality of life of infants and parents.

PI_NAMEs: JADCHERLA, SUDARSHAN R (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Acute;Address;Age;Algorithmic Analysis;Algorithms;Apple;Behavioral;behavioral response;Biofeedback;Biological Markers;biomarker validation;Caring;Cessation of life;Characteristics;Chronic;Clinical;clinical care;clinical decision-making;cost estimate;Coupled;Data;data acquisition;Data Analyses;Decision Making;Deglutition;Deglutition Disorders;Dehydration;design;Development;Diagnosis;Diagnostic;diagnostic algorithm;diagnostic biomarker;Digestive System Disorders;Distal;Eating;Economic Burden;Effectiveness;electric impedance;Eligibility Determination;Enteral Feeding;Esophagus;Esophagus motility;expectation;feeding;Feeding Methods;Feeds;Functional disorder;Funding;Gastroenterology;Goals;Growth;Health;Health Care Costs;healthcare burden;Hospitals;Impairment;improved;Infant;insight;Intervention;Juice;Knowledge;Length of Stay;Liquid substance;Malnutrition;Managed Care;Manometry;Mathematics;Medical Research;Methods;Milk;Mission;Monitor;Motility;Motor;National Institute of Diabetes and Digestive and Kidney Diseases;Neonatal;Neonatal Intensive Care Units;neurodevelopment;Neurodevelopmental Deficit;neuropathology;novel;novel diagnostics;novel therapeutics;nutrition;Nutrition Disorders;Oral;Outcome;Parenting Education;Parents;Pathologic;Perinatal;personalized diagnostics;Pharyngeal structure;Physiologic Monitoring;Physiological;Pregnancy;premature;Prevalence;Process;Productivity;Protocols documentation;Provider;Public Health;Quality of life;Recovery;Reflex action;Rehabilitation therapy;Reproducibility;Research;Resolution;response;Risk;Safety;safety testing;Saline;Sensory;Side;socioeconomics;Sterility;Stimulus;Sucrose;Survivors;Symptoms;System;Taste Perception;Techniques;Technology;Testing;Time;Training;Translational Research;Translations;Upper Esophageal Sphincter;Variant;Visit;Water

PROJECT_TITLE: Aerodigestive Pathophysiology-Driven Mechanisms of Infant Feeding Difficulties

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Violence Research

PHR: PROJECT NARRATIVE The development of strategies and interventions for preventing or minimizing violent behavior in individuals with psychotic disorders has been limited, in part, by a lack of information about the effects of antipsychotic medications, and in particular clozapine, on violent acts in community settings. In this project, we will determine whether clozapine, when administered in real-world settings, decreases the risk for violent acts in individuals with schizophrenia at high risk for violence when compared to treatment with other antipsychotic medications, and investigate whether previously identified change mechanisms are operative in the effectiveness setting. Examining clozapine in this way will foster a better understanding of the effects of clozapine on violent acts in community settings and allow us to test a scalable intervention and service delivery approaches that can be broadly implemented using typically available resources, and as such has significant public health implications.

PI_NAMEs: JARSKOG, LARS FREDRIK (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Address;Aggressive behavior;Alcohol consumption;Alcohols;Antipsychotic Agents;antisocial behavior;Behavior;blind;Clinical;Clinical Research;clinical research site;Clinical Trials;clinically relevant;Clozapine;Collaborations;community partners;community setting;community violence;Data;Delusions;Development;Diagnostic;Disparate;Effectiveness;effectiveness outcome;effectiveness study;efficacy trial;Ensure;Fostering;Future;high risk;Hostility;Human Resources;improved;Impulsivity;Individual;individual patient;interest;Intervention;intervention delivery;Interview;Link;Magnetic Resonance Imaging;Measures;Multi-Institutional Clinical Trial;Murder;Neurobiology;New York;open label;Outcome;Outcome Measure;Outpatients;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Populations at Risk;Positron-Emission Tomography;prevent;primary outcome;Property;Protocols documentation;psychopathic personality;Psychoses;psychotic;Psychotic Disorders;Public Health;Randomized;randomized, clinical trials;Research;Research Domain Criteria;Resources;Risk;Risk Reduction;Running;Safety;Sample Size;Schizophrenia;Sedation procedure;Self-Injurious Behavior;service delivery;Site;social stigma;substance use;Symptoms;Syndrome;Testing;Time;treatment as usual;treatment effect;Violence;violence prevention;Vulnerable Populations;Work

PROJECT_TITLE: 3/7 Clozapine for the Prevention of Violence in Schizophrenia: A Randomized Clinical Trial


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Dissemination and Implementation Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_STATE: WA

PHR: PROJECT NARRATIVE Adolescent intimate partner violence (IPV) is widespread, and states are increasingly enacting laws that require school districts to adopt policies for addressing IPV. The proposed research aims to assess the impact of state IPV laws on reducing adolescent IPV, assess if and how high schools in the U.S. implement these laws, and develop and test a toolkit to guide implementation. Findings will provide actionable evidence for schools that carry out the laws, state and local departments of education that provide guidance and hold schools accountable for implementing the laws, and policymakers who may amend or create laws in the future.

PI_NAMEs: ADHIA, AVANTI B (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: acceptability and feasibility;Accountability;Address;Administrator;Adolescent;Adolescent Risk Behavior;Adopted;Adult;adverse outcome;aged;Amendment;Anxiety;Area;Award;Behavior;bullying;career networking;Cessation of life;Communication;Country;Data;Development;econometrics;Education;Educational Curriculum;Effectiveness;effectiveness evaluation;emotional abuse;Ensure;Evaluation;expectation;experience;feasibility testing;Feeling suicidal;Future;Grant;Health;Health Policy;high school;implementation evaluation;implementation facilitation;implementation facilitators;implementation science;improved;Individual;Intervention;Interview;intimate partner violence;Laws;Legal;Link;Medicine;Mental Depression;Mentorship;Modeling;Oral;Outcome;Pathway interactions;Phase;physical abuse;Play;Policies;Policy Maker;Prevalence;prevent;Prevention education;Prevention strategy;Primary Prevention;Procedures;protective factors;Public Health;Public Policy;Qualitative Methods;Reporting;Research;Research Personnel;response;Role;Sampling;school district;school health;school violence prevention;Schools;Sexual abuse;skills;Social Environment;Statutes and Laws;Students;substance use;Surveillance Methods;System;teacher;Teen Dating Violence;Testing;Time;Training;United States;Victimization;violence prevention;violence victimization;Writing

PROJECT_TITLE: Assessing the impact and implementation of state laws for adolescent intimate partner violence


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Sarcopenia

ORG_CITY: CLEVELAND

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Heart failure represents one of the most significant burdens to patients of advanced age and often presents with sarcopenia, or muscle wasting, which is independently predictive of poor outcomes. The objective of this project is to develop a novel quantitative magnetic resonance imaging technology and use it to characterize the skeletal muscle and myocardium in heart failure patients with sarcopenia. This project will advance the career development pursued by the investigator as well as provide a novel imaging tool that can help to improve the assessment, and potentially the clinical management, of heart failure patients with sarcopenia.

PI_NAMEs: ECK, BRENDAN LEE (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Address;Affect;Aging;aging population;aging related disease;Assessment tool;Biological Assay;Biology;Biology of Aging;biomedical imaging;Biopsy;Biopsy Specimen;Blood capillaries;bone imaging;cardiac aging;cardiac magnetic resonance imaging;Cardiopulmonary;cardiovascular imaging;career development;Career Mobility;Characteristics;Chronic Disease;Chronology;Clinical;Clinical assessments;Clinical Management;Consumption;density;Deposition;Deterioration;Development;Development Plans;Diabetes Mellitus;Disease;Doctor of Philosophy;Dual-Energy X-Ray Absorptiometry;Edema;Elderly;Evaluation;Exhibits;Fatty acid glycerol esters;Fiber;Fibrosis;Fingerprint;frailty;General Population;Goals;grasp;Hand Strength;healthy volunteer;Heart;Heart failure;heart imaging;human subject;Hypertension;Image;Imaging Device;Imaging technology;Impairment;improved;in vivo evaluation;Individual;insight;Interdisciplinary Study;Knowledge;Link;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mentorship;Metabolic;Methods;Mitochondria;mitochondrial dysfunction;Morphologic artifacts;mortality;Muscle;muscle form;Muscle function;Muscular Atrophy;Myocardial dysfunction;Myocardial tissue;Myocardium;Noise;novel;Organ;Outcome;Pathologic;Pathway interactions;Patients;Performance;Population;Process;programs;Property;Proteins;Quality of life;Questionnaires;Relaxation;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;research study;Rotation;sarcopenia;Scanning;simulation;Site;Skeletal Muscle;skeletal muscle wasting;skills;Techniques;Technology;Testing;Thigh structure;Time;Tissues;tool;Training;Walking;X-Ray Computed Tomography

PROJECT_TITLE: Characterization of sarcopenia in heart failure by T1rho magnetic resonance fingerprinting

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Facioscapulohumeral Muscular Dystrophy;Genetics;Muscular Dystrophy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE The proposed research will identify the fundamental molecular mechanisms that epigenetically repress the D4Z4 region through the production, modification, stability and interacting partners of SMCHD1. The health relevance of this research is that the failure of these mechanisms results in facioscapulohumeral muscular dystrophy and the proposed studies will provide the basis for future therapeutic development.

PI_NAMEs: TAPSCOTT, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Affect;autosome;Binding;Binding Sites;Cell Differentiation process;Cell Reprogramming;Cells;Chromatin;chromatin modification;Chromatin Structure;Complex;D4Z4;Dependence;Development;Disease;DNMT3B gene;Epigenetic Process;epigenetic regulation;Facioscapulohumeral;Facioscapulohumeral Muscular Dystrophy;Failure;Family;Future;Gene Mutation;Genome;Goals;Health;human induced pluripotent stem cells;Intervention;Maintenance;Mediating;Modeling;Modification;Molecular;Molecular Biology;Muscle Cells;Mutation;Pathway interactions;Persons;Post-Translational Protein Processing;prevent;Production;protein complex;Proteins;recruit;Regulation;Repetitive Sequence;Repression;Research;Role;Set protein;Skeletal Muscle;stem cells;Testing;therapeutic development;therapy design;therapy development;Validation

PROJECT_TITLE: SMCHD1 Pathways as Candidate Targets for FSHD

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Natural Products;Neurodegenerative;Neurosciences

ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE  The aging population in the United States exacerbates the economic and societal impacts of neurodegenerative disorders, which are among the leading causes of death and disability in the elderly. Novel therapeutic targets need to be investigated to address these illnesses, including improving understanding the molecular mechanisms of their inhibition. This proposal describes the development of first-row transition metal catalyzed transformations to provide laboratory routes to generate structurally diverse complex molecules that are inhibitors of PTP1B, a protein recently implicated in neurodegeneration.

PI_NAMEs: NEWHOUSE, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Address;aging population;Alzheimer's Disease;Alzheimer's disease model;American;analog;Architecture;Binding;Binding Sites;Brain-Derived Neurotrophic Factor;Carbon;Catalysis;Cause of Death;Chemicals;Clinical Trials;cognitive function;Collaborations;Complex;cost;dehydrogenation;deprotonation;Derivation procedure;design;Development;disability;Docking;drug development;Economics;Elderly;empowerment;Etiology;Evaluation;Exhibits;flexibility;Goals;Hippocampus;improved;inhibitor;invention;Investigation;J20 mouse;Laboratories;Ligands;Mediating;Medicine;member;Memory impairment;metal complex;Metals;meter;Methodology;Methods;Modification;Molecular;Molecular Mechanisms of Action;mouse model;Mus;Natural Products;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;neuron loss;Neuronal Dysfunction;neuronal growth;neuronal survival;new therapeutic target;novel;Parkinson Disease;Pathology;Pharmaceutical Chemistry;Pharmacologic Substance;Phase;Phosphotransferases;Positioning Attribute;prevent;Property;Protein Dephosphorylation;Protein Inhibition;protein tyrosine phosphatase 1B;Proteins;Reaction;receptor;Research;Role;Route;scaffold;Scheme;Signal Pathway;small molecule;social;spatial memory;Structure-Activity Relationship;Terpenes;Therapeutic;therapy development;Transition Elements;Tropomyosin;United States

PROJECT_TITLE: Synthesis of Neurologically Active Small Molecules

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Health relevance The research described in this new application has direct relevance to human health in that we are investigating the mechanism of action of novel therapeutic agents to be used in the treatment of human cancer. We will conduct research exploiting a novel mechanism to impact the DNA damage response pathway to allow more effective treatment of human cancer.

PI_NAMEs: TURCHI, JOHN J. (contact)

PROJECT_TERMS: Address;anticancer activity;ataxia telangiectasia mutated protein;Automobile Driving;Biochemical;cancer cell;cancer type;Cell Death;Cells;Characteristics;CHEK1 gene;CHEK2 gene;chemical genetics;Chemicals;Chromosomal Rearrangement;Chromosomes;Clinical;Clinical Trials;clinically relevant;Combined Modality Therapy;Coupled;CRISPR screen;Data;Developmental Therapeutics Program;DNA Binding;DNA Damage;DNA Repair Pathway;DNA-dependent protein kinase;driver mutation;Drug Targeting;effective therapy;Epithelial Cells;Epithelial ovarian cancer;exhaustion;Genetic;Genetic Determinism;Genetic Models;genome sequencing;Genomic DNA;Health;homologous recombination deficiency;Human;in vivo;Individual;inhibitor;inhibitor therapy;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Methodology;Modeling;Molecular;Mutation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Oncogenic;Pathway interactions;patient derived xenograft model;patient response;Patients;personalized medicine;pharmacologic;Phosphotransferases;PIK3CG gene;Play;Poly(ADP-ribose) Polymerase Inhibitor;Publishing;repaired;replication factor A;replication stress;Research;response;Role;Series;Serous;Signal Transduction;Single-Stranded DNA;small molecule;spheroids;SS DNA BP;success;synthetic lethal interaction;targeted agent;targeted cancer therapy;targeted treatment;Therapeutic;Therapeutic Agents;therapeutic target;Toxic effect;treatment response;treatment strategy;tumor;whole genome

PROJECT_TITLE: Novel DNA damage response therapeutics targeting replication protein A

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, are debilitating and highly prevalent chronic conditions. The strongest genetic associations lie within the human leukocyte antigen (HLA) genes, which play a critical role in activating the immune system, but exactly how HLA variants increase risk for autoimmunity is not fully understood. This project will use paired genomic and single-cell transcriptomic data from inflamed human tissues to explore how genetic variants regulate HLA expression, link these effects to specific disease-driving cell states, and improve our understanding of how autoimmunity is initiated and hopefully lead to new treatment strategies.

PI_NAMEs: KANG, JOYCE BLOSSOM (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acceleration;Affect;Alleles;antigen binding;Antigen Presentation;Autoimmune Diseases;Autoimmunity;Automobile Driving;autoreactive T cell;Binding Sites;Biological;cell type;Cells;Chromosome 6;Chronic;Clinical;Code;cohort;Communication;comparison control;Complex Genetic Trait;Computing Methodologies;Data;Data Science;Data Set;Dendritic Cells;Disease;disorder risk;Environment;Fibroblasts;Funding;Gene Expression;Genes;Genetic;genetic association;Genetic Transcription;genetic variant;Genetic Variation;Genome;genomic data;Genomics;Genotype;Grain;high dimensionality;Histocompatibility;Histocompatibility Antigens Class I;Histocompatibility Antigens Class II;HLA Antigens;Human;human disease;Human Genetics;human model;human tissue;Immune;Immune system;Immunogenomics;Immunology;improved;Individual;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;innovation;Interferon Type II;Knowledge;Label;Lead;Link;Macrophage;Maps;Mediating;Medicine;Mentorship;method development;Methods;MHC Class II Genes;Modeling;Molecular;multimodal modeling;multiple datasets;Myelogenous;Myeloid Cells;National Institute of Allergy and Infectious Disease;novel strategies;novel therapeutic intervention;Pathogenicity;Patients;Peptides;personalized approach;Physicians;Play;Population;Process;programs;protein structure;Publishing;Quantitative Trait Loci;reference genome;Regulation;Research;Resolution;Resources;response;Rheumatoid Arthritis;Risk;risk variant;Role;Sampling;Scientist;Single Nucleotide Polymorphism;single-cell RNA sequencing;skills;Statistical Models;Stromal Cells;Surface;Synovitis;Systemic Lupus Erythematosus;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Tissues;Training;Transcription Coactivator;transcription factor;transcriptomics;translational immunology;Untranslated RNA;Variant;Work

PROJECT_TITLE: Pinpointing how single-cell states affect genetic regulation of HLA expression in autoimmune diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]