ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Many patient advocacy groups are working passionately to improve care and outcomes for specific diseases and vulnerable populations, but best methods to achieve these goals are unknown. Equal collaboration between clinicians, researchers, and advocacy groups utilizing implementation science methods is underutilized and promises to increase use of evidence-based interventions in clinical practice to increase quality of life and reduce disability and illness. This K18 training program will educate a successful clinical trialist in implementation science so that he can increase the use of these methods in clinical contexts and teach the methods to other clinician scientists.

PI_NAMEs: BLAKELY, MARTIN LEE (contact)

PROGRAM_OFFICER_NAME: GRIFFIOEN, MARI

PROJECT_TITLE: Advancing patient advocacy group-driven research via implementation science

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Hematology;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Project Narrative The goal of this proposal is to test our hypothesis that hepatitis C virus NS5A inhibitors Elb and Dac can be developed into cancer therapeutic agents. We will determine the role of HCV NS5A inhibitors in overcoming cancer cell intrinsic resistance to and TME-induced extrinsic protection from chemotherapies and elucidate the underlying mechanisms.

PI_NAMEs: YI, QING  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Adrenal Cortex Hormones;Aftercare;Alkylating Agents;analog;Anti-viral Agents;Antineoplastic Agents;ATP phosphohydrolase;Breast Cancer Cell;cancer cell;Cancer Patient;cancer therapy;cancer type;Cell Death;Cell Death Induction;Cell Line;Cells;Chemoresistance;chemotherapy;Cholesterol;Clinical;clinical application;Complex;Data;Deoxycytidine;Dexamethasone;Disease;Dose;Doxorubicin;Drug Efflux;Drug resistance;Estrogen receptor positive;experience;FDA approved;Felis catus;Fluorouracil;Future;gemcitabine;Goals;Hematologic Neoplasms;Hepatitis C virus;Human;improved;in vivo;inhibitor;Interferon Type I;Interferons;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Melphalan;mouse model;Multiple Myeloma;neoplastic cell;Normal Cell;Normal tissue morphology;novel;Pancreatic Ductal Adenocarcinoma;Patients;Pharmaceutical Preparations;Phospholipids;Proteasome Inhibitor;protective effect;Publishing;refractory cancer;Relapse;replicase;Reporting;Resistance;Role;side effect;Solid;Solid Neoplasm;Stromal Cells;Stromal Neoplasm;Tamoxifen;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Agents;tool;Toxic effect;Treatment Efficacy;Treatment outcome;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Tumor-associated macrophages;uptake

PROJECT_TITLE: Exploring the role and potential of anti-viral drugs to sensitize cancer cells to chemotherapy

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SEATTLE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Aging associated muscle loss, pathologically called sarcopenia, is related to dysfunctional mitochondria, metabolism, muscle function. Exercise and resistance training have been identified as one of the few viable therapies to slow or possibly reverse sarcopenia. This proposal is designed specifically with the goal of establishing naturally aged three-dimensional engineered muscle tissue differentiated as a model for metabolic testing to investigate and identify molecular mechanisms that contribute to sarcopenia that may be targeted for therapies.

PI_NAMEs: CAMPBELL, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: 3-Dimensional;Acute;Affect;Age;age effect;age related;Age Years;aged;Aging;aging related;Award;Bioenergetics;Biological;Biological Assay;Biology;Biology of Aging;cardiorespiratory fitness;cell immortalization;Cell Line;Cell Reprogramming;Cells;Circulation;Citric Acid Cycle;Collaborations;Complex;Data;Depressed mood;design;Development;Devices;Enrollment;Environment;Exercise;exercise training;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;fitness;frailty;Functional disorder;Future;Glutamates;Goals;hallmarks of aging;Health;Human;Human Cell Line;human model;Impairment;improved;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Infiltration;insight;Link;Longitudinal Studies;Maintenance;Measures;Mechanics;Mediating;Metabolic;Metabolism;metabolomics;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Mus;Muscle;muscle aging;Muscle Contraction;muscle engineering;muscle form;Muscle function;Muscle Mitochondria;Muscular Atrophy;Myoblasts;novel;old mice;older adult;Organelles;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Stress;Oxygen Consumption;Participant;Pathologic;pathological aging;Patients;Phenocopy;Phenotype;pluripotent stem cell differentiation;Positioning Attribute;Production;Proteomics;Protocols documentation;Regenerative Medicine;Relaxation;Research;Research Design;research study;resistance exercise;response;Sampling;sarcopenia;Shock;Signal Transduction;Site;Skeletal Muscle;skeletal muscle wasting;Spirometry;stem cells;Stress;targeted treatment;Testing;Time;Tissue Differentiation;Tissue Engineering;Tissue Model;Training;translational model;United States National Institutes of Health;Universities;University resources;Washington;Work

PROJECT_TITLE: Metabolic response to contraction in a 3D engineered muscle tissue model of aging

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Data Science;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Nutrition;Obesity;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Anti-obesity medications designed to reduce excess body fat or “adiposity” contribute to weight loss and substantially reduce the risk of heart disease. The genetic impact of adiposity on lipid levels—both critical risk factors for heart disease—remains uncertain but holds considerable clinical and therapeutic potential. This proposal will leverage comprehensive clinical and multi-omics data from large-scale cohorts to uncover key biological components at the intersection of adiposity and lipid pathways, potentially advancing heart disease risk assessment and identifying new therapeutic targets for individuals with obesity.

PI_NAMEs: DRON, JACQUELINE SHIRLEY (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Abdomen;Address;Adipose tissue;Advisory Committees;Affect;American;biobank;Biological;Biology;Biometry;blood lipid;Body fat;Body mass index;Body Weight decreased;Cardiology;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cardiovascular risk factor;Cardiovascular system;career;career development;Cause of Death;Cessation of life;Cholesterol;Clinical;Clinical Data;clinical risk;cohort;collaborative environment;Complex;computing resources;Coronary Arteriosclerosis;Coupled;Data;data access;Data Analyses;Data Set;design;disorder risk;DNA;Etiology;Event;experience;Foundations;Future;Genetic;Genetic Determinism;Genetic Research;genome wide association study;genome-wide;genomic data;genomic locus;Genomic medicine;Genomics;Goals;Health;heart disease risk;Heart Diseases;Heritability;Human Genetics;Hyperglycemia;Hypertension;Individual;innovation;insight;interest;Investigation;large scale data;Lead;Learning;Link;lipid metabolism;Lipids;Lipoproteins;Longitudinal cohort;Magnetic Resonance Imaging;Measures;Mediating;Mediation;member;Mendelian randomization;Mentors;Mentorship;Meta-Analysis;Metabolism;Modeling;mortality;Multiomic Data;multiple omics;National Heart, Lung, and Blood Institute;Nature;new therapeutic target;novel;novel strategies;Obesity;Pathway interactions;Pharmaceutical Preparations;polygenic risk score;Population;Population Heterogeneity;Prevention;Proteins;Proteomics;Quantitative Trait Loci;Research;Research Personnel;Research Proposals;Resources;Risk;Risk Assessment;Risk Factors;risk prediction model;Risk Reduction;Role;Sampling;Scientist;Statistical Methods;Statistical Models;statistics;subcutaneous;Techniques;Testing;Therapeutic;Time;Tissues;Training;trait;transcriptome sequencing;transcriptomics;Triglycerides;Variant;Visceral;whole genome;Work

PROJECT_TITLE: Multi-omic investigation of the adiposity-lipid intersection and its role in cardiovascular disease risk

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (MA)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Mitochondrial stability and activity support changes in neurons in reward-related areas of the brain in response to exposure to drugs contributing to substance use disorders, including nicotine. The current proposal seeks to determine how nicotine changes mitochondria and chromatin accessibility in specific neuron populations and how this influences the rewarding effects of nicotine that make smoking cessation difficult. This work will contribute to a novel understanding of drug-induced changes in the brain and will link epigenetic processes to mitochondrial signaling pathways, providing new therapeutic targets downstream of epigenetic modifications for substance use disorders.

PI_NAMEs: CALARCO, CALI ANN (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Abstinence;Acetyl Coenzyme A;Activities of Daily Living;Area;ATAC-seq;Automobile Driving;Behavior;Behavioral;Biological Models;Brain;Brain region;brain tissue;cell type;Chromatin;chromatin modification;Chronic;Cocaine;cocaine seeking;comorbidity;Complex;Corpus striatum structure;craving;CRISPR interference;CRISPR-mediated transcriptional activation;Cues;Data;Dendrites;density;Dopamine D2 Receptor;Drug Controls;drug relapse;drug reward;drug seeking behavior;Drug usage;Electron Transport;Electronic cigarette;Electrophysiology (science);Epigenetic Process;epigenome;Exposure to;Fluorescent in Situ Hybridization;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;Genome;Guide RNA;Hippocampus;Histone Deacetylase;Histone Deacetylase Inhibitor;histone modification;improved;Individual;insight;Intake;Intravenous;Label;Learning;Length;Link;Measures;Mediating;Metabolic;Mitochondria;Modification;Molecular;Molecular Target;Morphology;mouse model;multiple omics;Mus;Neurons;new therapeutic target;Nicotine;nicotine reward;nicotine seeking behavior;nicotine self-administration;nicotine use;Nicotine Use Disorder;novel;Nucleus Accumbens;Pathway interactions;Pharmaceutical Preparations;polysubstance use;Population;Production;programs;Property;Psychological reinforcement;Regulation;Regulator Genes;Relapse;Respiration;respiratory;response;Rewards;selective expression;Self Administration;Signal Pathway;single nucleus RNA-sequencing;skills;smoking cessation;Specificity;substance use;Substance Use Disorder;Techniques;Testing;Therapeutic;Tissues;Tobacco;training opportunity;transcription factor;Transgenic Mice;Translating;Venous;Vertebral column;Viral Vector;Work

PROJECT_TITLE: Cell-Type Selective Transcriptional and Mitochondrial Control of Drug Seeking

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


PHR: PROJECT NARRATIVE Current best practice guidelines and regulatory mandates for sepsis encourage immediate administration of broad-spectrum antibiotics to any patient with suspected sepsis, contributing to a high rate of overuse of antibiotics directed at methicillin-resistant Staphylococcus aureus and multidrug-resistant Gram-negative organisms. The proposed research seeks to quantify the impact of overly broad and overly narrow initial antibiotic coverage in a large multi-hospital cohort of patients with suspected sepsis, and then identify specific phenotypes of sepsis for which overly broad antibiotics can be safely avoided, by combining electronic health record data with information on symptoms and risk factors for multidrug resistant organisms extracted from clinical notes with large language models. This study will have important clinical and public health implications by quantifying the unintended adverse consequences of broad antibiotic use, helping clinicians select safer antibiotic choices for patients with potential sepsis, and enabling new data-driven strategies for antimicrobial stewardship.

PI_NAMEs: PAK, THEODORE ROBERTSON (contact)

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: Identifying Sepsis Phenotypes Associated with Antibiotic-Resistant Pathogens Using Large Language Models and Machine Learning


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Data Science;Dental, Oral, and Craniofacial Disease;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Poor oral health negatively affects vulnerable and underserved populations that disproportionally rely on emergency departments (EDs) for treatment of non-traumatic dental conditions. This research will use advanced health informatics approaches and leverage electronic health record data to better address oral health disparities among underserved adults, including minority racial and ethnic groups, rural populations, and those with lower socioeconomic status, who seek non-traumatic dental treatment in emergency departments.

PI_NAMEs: TAYLOR, HEATHER LYNN (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Accident and Emergency department;Address;Adult;Affect;algorithmic bias;care delivery;care providers;career;career development;Caring;Categories;Chronic Disease;Clinical;clinical encounter;clinical predictors;Communities;Data;data repository;Data Sources;data standards;Decision Trees;demographics;Dental;Dental Care;Development;Documentation;Electronic Health Record;electronic structure;Emergency department crowding;Emergency department visit;Environment;Environmental Risk Factor;Ethnic Population;experience;Fostering;Frustration;Future;Goals;gradient boosting;Grant;Health;Health Care Costs;health care delivery;health data;Health Disparities Research;health disparity;health information technology;Health Services;Health Services Research;Health system;Healthcare;Hospitals;improved;Individual;Inequity;innovation;Institution;K-Series Research Career Programs;Knowledge;Link;low socioeconomic status;Machine Learning;machine learning classification;machine learning prediction;marginalized population;Measures;Medical;Mentors;Mentorship;model building;model design;Modeling;National Institute of Dental and Craniofacial Research;Natural Language Processing;novel;Oral;Oral health;Outcome;Patient Care;Patients;Performance;Personal Satisfaction;Population;population health;predictive modeling;Public Health Informatics;racial minority population;random forest;Recommendation;Research;research and development;Research Personnel;Research Project Grants;Resort;Resources;Risk;risk prediction;risk prediction model;Rural Population;Series;Services;skills;social;social determinants;social factors;social health determinants;Source;Strategic Planning;Structure;structured data;study population;System;Techniques;Testing;Training;Underserved Population;United States;United States National Institutes of Health;unstructured data;Validation;Vulnerable Populations;Writing

PROJECT_TITLE: Leveraging health systems' data to address oral health disparities

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Lupus;Physical Activity;Prevention;Rehabilitation

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

ORG_STATE: NY

PHR: PROJECT NARRATIVE While adults with systemic lupus erythematosus, a chronic autoimmune disease, now live routinely to 50 years of age and beyond, they remain at increased risk for poor health compared to older adults without lupus as they get older. Frailty, a state of decreased physiologic reserve, is a risk factor for poor health outcomes. The objective of this project is to adapt and pilot test a tablet-based physical activity intervention with embedded team-driven social support for frail and pre-frail adults with lupus 50 years of age and above, with the ultimate goal of improving their overall health and wellbeing.

PI_NAMEs: LIEBER, SARAH BETH (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Accident and Emergency department;Adult;Affect;Age Years;aged;Aging;arm;Behavior;Behavior Therapy;behavioral health intervention;Behavioral Model;Caring;Chest Pain;chronic autoimmune disease;clinically relevant;comorbidity;Computer software;Consensus;Data;depressive symptoms;design;Development;digital;disability;Disease;Double-Blind Method;Educational Activities;eligible participant;evidence base;Exclusion;Exercise;exercise intervention;Exercise Therapy;experience;Fatigue;Flare;Frail Elderly;frailty;functional status;General Population;Goals;Guidelines;Health;health related quality of life;heuristics;high risk;Hospitalization;improved;Individual;instrument;Intervention;Interview;Lupus;Malignant Neoplasms;Mediator;Modeling;mortality;multidisciplinary;multiple chronic conditions;Musculoskeletal Pain;older adult;Organ;Outcome;Pain;Participant;Personal Satisfaction;Photosensitivity;Physical activity;physical conditioning;Physical Fitness;Physical Function;physical therapist;Physiological;pilot test;poor health outcome;Population;Process;programs;prototype;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research;rheumatologist;Risk;Risk Factors;sedentary;Self Efficacy;social cognitive theory;Social support;stakeholder perspectives;Structure;Suggestion;Symptoms;System;Systemic Lupus Erythematosus;Tablets;Target Populations;Technology;therapy development;United States National Institutes of Health;usability;user centered design;Vulnerable Populations;Woman

PROJECT_TITLE: Tablet-Based Physical Activity Intervention for Frail and Pre-Frail Older Adults with Systemic Lupus Erythematosus

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Services;Prevention;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Identification of hereditary pathogenic germline variants in patients with colorectal cancer (CRC) informs treatment, surveillance, and familial cascade testing to reduce cancer incidence, morbidity, and mortality, yet rates of germline genetic testing in CRC are poor. Mainstream genetic testing (MGT) is an effective pathway to increase genetic testing in cancer patients, however it has not been widely adopted. This proposal seeks to increase genetic testing in CRC by tailoring and piloting an implementation strategy to increase the uptake of MGT.

PI_NAMEs: HOLLIS, ROBERT H (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adopted;Alabama;Benefits and Risks;Cancer Center;Cancer Patient;cancer risk;cancer type;career development;cascade genetic testing;Clinic;Clinical;Clinical Data;colon cancer patients;Colorectal Cancer;Consolidated Framework for Implementation Research;Counseling;Data;Development Plans;Diagnosis;Education;Educational Materials;effectiveness/implementation trial;Ethnic Origin;Evaluation;experience;Exposure to;Failure;Familial Adenomatous Polyposis Syndrome;familial colorectal cancer;Family;Genetic;genetic counselor;genetic testing;Germ Lines;Germ-Line Mutation;Goals;Guidelines;Health Personnel;Hereditary Malignant Neoplasm;Hereditary Nonpolyposis Colorectal Neoplasms;implementation evaluation;implementation science;implementation strategy;improved outcome;Incidence;Individual;Inherited;Institution;Intervention;Interview;Knowledge;lifetime risk;Mainstreaming;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical Oncologist;Mentors;Methods;Morbidity - disease rate;mortality;non-genetic;Office Nursing;Outcome;Outcomes Research;Pathogenicity;Pathway interactions;Patient Education;Patient-Focused Outcomes;Patients;Perception;pilot test;post implementation;preference;Private Practice;Provider;Race;Radiation Oncologist;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Reporting;Research;Research Personnel;Resources;screening;Structure;Surgeon;Surveys;Syndrome;Testing;Training;tumor;uptake;Work

PROJECT_TITLE: Piloting an Implementation Strategy for Mainstream Genetic Testing in Colorectal Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Infectious Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Staphylococcus aureus is the most common bacterial cause of mortality in the United States and is associated with rates of antibiotic treatment failure in excess of 15% for some types of infections. Depletion of arginine, an essential amino acid, leads to an increase in antibiotic failure in mature S. aureus communities through unclear mechanisms. Using a combination of in vitro experiments, tissue culture, in vivo mouse infection models, and advanced imaging mass spectroscopy, I will test the hypothesis that S. aureus is able to regulate the level of arginine to promote its own survival and persistence in the presence of antibiotics and the innate immune system.

PI_NAMEs: FREIBERG, JEFFREY ALEXANDER (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Abscess;Address;Animal Model;Antibiotic Resistance;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Arginine;Award;Bacteria;Bacterial Infections;Biological Availability;Catabolism;Cell Culture Techniques;Cell Physiology;Cells;Cessation of life;Chronic;chronic infection;Clinical;clinically significant;combat;Communicable Diseases;Communities;conventional therapy;Data;Death Rate;drug development;Effector Cell;Endocarditis;Essential Amino Acids;Eukaryotic Cell;experimental study;Exposure to;Failure;Fellowship;Future;Genes;Genetic;Goals;Growth;Image;Immune;immune clearance;Immune response;Immune system;improved;In Vitro;in vivo;Incidence;Individual;Infection;Innate Immune Response;Innate Immune System;insight;interest;K-Series Research Career Programs;Lead;Macrophage;mass spectrometric imaging;Mass Spectrum Analysis;Mediating;Mentors;Mentorship;Metabolic Pathway;Metabolism;Modeling;mortality;Mus;mutant;neutrophil;new therapeutic target;Nitric Oxide;Nitric Oxide Synthase;NOS2A gene;Osteomyelitis;Outcome;pathogen;Pathogenesis;Pathway interactions;Pattern;Penetration;Periprosthetic joint infection;Phagocytes;Phenotype;Physicians;Production;programs;protein expression;Proteins;Proteomics;Regulation;Research;response;Role;Scientist;Side;skills;Staphylococcus aureus;Staphylococcus aureus infection;Stress;Testing;tissue culture;Tissues;Treatment Failure;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Understanding the role of arginine metabolism in antibiotic treatment failure during Staphylococcus aureus infections

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Childhood exposure to violence (CEV) in early childhood is a significant and preventable public health problem in the United States, and pediatric healthcare settings are centrally positioned to identify and intervene upon early CEV. The proposed research aims to (1) understand existing CEV assessment tools and follow-up processes in pediatric primary care settings; (2) identify facilitators of and barriers to routine CEV assessment in these settings; (3) characterize patterns of early CEV assessment across one large medical system; and (4) determine whether these assessments are associated with subsequent healthcare referral, follow-up care receipt, and child health outcomes. Findings will provide translatable information for primary care settings implementing the recent Joint Commission mandate to assess social and environmental risks across health settings, and highlight areas for future measurement and implementation science research.

PI_NAMEs: BENDER SWEET, ANNA ELISABETH (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Adolescent;Adult;Adverse event;Age;Area;Assessment tool;Award;Behavioral;Big Data;career networking;Caring;Characteristics;Child;Child Health;Child health care;Child Welfare;Childhood;Cognitive;Data;Data Analyses;Data Set;Development;Developmental Process;Documentation;early childhood;early life adversity;Electronic Health Record;Emergency department visit;Ensure;Environmental Risk Factor;experience;Family;follow-up;food insecurity;Future;Grant;gun violence;Health;health care referral;health care service utilization;health care settings;health disparity;Health system;Healthcare;Healthcare Systems;high risk;Holistic Health;Human Resources;implementation efforts;implementation evaluation;implementation science;improved;Injury;Interruption;Intervention;Interview;Joints;Life Cycle Stages;maltreatment;marginalized population;Measurement;Medical;Medicine;Mentorship;Minority Groups;National Institute of Child Health and Human Development;novel;Oral;Outcome;Pathway interactions;Patients;Pattern;pediatrician;Pediatrics;Personal Satisfaction;Phase;physical abuse;physical assault;Pilot Projects;Play;Positioning Attribute;prevent;primary care setting;Process;Property;Psyche structure;Psychometrics;Public Health;Reduce health disparities;Reporting;Research;Research Methodology;Research Personnel;Research Priority;Resources;Risk;Risk Assessment;Role;Schools;Series;sexual assault;Site;skills;social;social health determinants;Social outcome;Social Workers;Surveys;System;systematic review;Techniques;Testing;Time;Training;traumatic stress;United States;Universities;Violence;violence exposure;violence prevention;Washington;weapons;Well Child Visits;Work;Writing

PROJECT_TITLE: Assessing for and Intervening upon Early Childhood Violence Exposure in Pediatric Primary Care Settings

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Numerous neurodevelopmental and neurodegenerative disorders are driven by aberrant levels of proteins that must remain tightly regulated for brain health, such as tau aggregation in Alzheimer’s disease. Large-scale cell- based screens have been used to discover previously unknown regulators of highly regulated proteins, however these screens require multiple rounds of strenuous validations to eventually identify the candidate that will then need to be tested in vivo. Here, this project will bypass cell-based screens by developing a high-throughput genome-wide in vivo CRISPR/Cas9 screening method, which will provide a powerful and efficient tool to identify new therapeutic targets for several neurological disorders driven by altered protein levels.

PI_NAMEs: KIM, JIYOEN  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 3-Dimensional;adenovirus mediated delivery;Affect;alpha synuclein;Alzheimer's Disease;Animals;Antibodies;Automobile Driving;Biological;Brain;brain cell;brain health;Brain region;Bypass;candidate identification;Cause of Death;Cell Culture Techniques;Cell Separation;Cells;Central Nervous System;Cerebral cortex;clinical translation;Computer Analysis;Consumption;Corpus striatum structure;CRISPR screen;CRISPR/Cas technology;Data;deep sequencing;Dependovirus;Detection;Disease;disease model;disease phenotype;Dissociation;effective therapy;Enterobacteria phage P1 Cre recombinase;Environment;Flow Cytometry;Fluorescence-Activated Cell Sorting;fly;Genes;Genetic;Genetic Screening;genome-wide;Goals;Green Fluorescent Proteins;Guide RNA;high throughput screening;Human;immunodeficient mouse model;improved;In Vitro;in vitro Assay;in vivo;in vivo evaluation;in vivo Model;Infection;Injections;innovation;insight;Label;Lead;Libraries;Malignant Neoplasms;Methods;Modeling;Molecular;mouse model;Mus;mutant;neonatal mice;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurodevelopmental Disorder;new therapeutic target;novel;novel therapeutic intervention;Outcome;Palliative Care;Parkinson Disease;particle;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Persons;Phenotype;Physiological;Population;postnatal;Process;Property;Proteins;red fluorescent protein;Regulation;Reporting;resilience;Risk;screening;Screening Result;small hairpin RNA;Stains;targeted treatment;tau aggregation;tau Proteins;Tauopathies;Testing;therapeutic candidate;therapeutic development;therapeutic target;Time;tool;Translating;Translations;tumor xenograft;Ubiquitin;Validation;Viral;Viral Packaging;Virus;Zebrafish

PROJECT_TITLE: In vivo Screening Methods Targeting Levels of Tau Protein within Mouse Brains

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSURGERY

PHR: Project narrative Outcomes in epilepsy surgery are dependent on correctly identifying and mapping the seizure onset zone and epileptic network. Despite recent advance, seizure freedom rates have not improved and have remained stagnant, which can be attributed to poor localization of epileptic tissue. In this study, we translate our recent findings of lactate upregulation in epileptic tissue to develop metabolic imaging of hyperpolarized 13C pyruvate as a novel tool to identify the seizure onset zone. 1

PI_NAMEs: KSENDZOVSKY, ALEXANDER  (contact);MAYER, DIRK

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Animals;Behavioral;Bicarbonates;Biological Assay;Biological Markers;Brain;brain tissue;Chronic;Clinical;clinical investigation;Clinical Trials;comparison control;Data;Disease;efficacy evaluation;Electrodes;Electroencephalography;Energy Metabolism;Epilepsy;Excision;extracellular;Freedom;Future;Glioma;glucose metabolism;Glycolysis;Healthcare Systems;HIF1A gene;Human;Hypoxia Pathway;Image;Imaging Device;imaging modality;Imaging Techniques;Immunofluorescence Immunologic;improved;in vivo;insight;Investigation;lactate dehydrogenase A;Lithium;Magnetic Resonance Imaging;Maps;Mediating;Medical;Metabolic;metabolic imaging;Metabolism;Methods;Modeling;Molecular;molecular imaging;mouse model;Mus;Neurons;new technology;NMR Spectroscopy;novel;Operative Surgical Procedures;Outcome;Oxidative Phosphorylation;Partial Epilepsies;Patient Selection;Patients;Pilocarpine;Polypharmacy;pre-clinical;Production;Pyruvate;Quality of life;Rattus;Resected;Seizures;Source;Specimen;surgery outcome;Techniques;Temporal Lobe;Temporal Lobe Epilepsy;Tissues;tool;Translating;Traumatic Brain Injury;tumor;Up-Regulation;Visualization;Warburg Effect

PROJECT_TITLE: Hyperpolarized MRI for Metabolic Imaging of Epileptic Tissue

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: MH

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Rehabilitation

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE Atypical sensorimotor behaviors are common in autism spectrum disorder (ASD), and they appear to be mechanistically related to clinical and cognitive traits and distinct in autistic individuals with co-occurring intellectual disability (ID). The proposed studies will characterize the motor and neurophysiologic mechanisms of multisensory (visual and somatosensory) feedback processing during sustained fine and gross motor control in school-aged autistic children with and without ID. Theses studies hold promise for identifying physiologic mechanisms contributing to clinical and cognitive challenges in ASD to aid the development of effective interventions and supports.

PI_NAMEs: SHAFER, ROBIN L (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Affect;Age;aged;autism spectrum disorder;autistic;autistic children;Behavior;Behavioral;Brain;Cerebellar Cortex;Cerebellum;Clinical;Clinical Data;clinical predictors;Cognition;Cognitive;cognitive function;communication behavior;Computer Analysis;Data;Dependence;design;Development;effective intervention;Electroencephalography;Exclusion;Feedback;Functional Magnetic Resonance Imaging;functional outcomes;Goals;grasp;Impairment;improved;improved outcome;Individual;individuals with autism spectrum disorder;Intellectual functioning disability;Intervention;machine learning model;Mentors;Mentorship;model of autism spectrum disorder;Motor;motor behavior;motor control;Motor Cortex;Movement;multidisciplinary;multimodality;multisensory;Musculoskeletal Equilibrium;neural;neurophysiology;neuroregulation;Neurosciences;novel;Outcome;Parietal;Parietal Lobe;Pathway interactions;Pattern;Persons;Physiological;Physiological Processes;Physiology;Population;Posture;Prevalence;Process;Quality of life;repetitive behavior;Research;Research Personnel;Role;scaffold;Scalp structure;School-Age Population;Sensorimotor functions;sensory feedback;sensory input;Severities;sex;social communication;somatosensory;supervised learning;Symptoms;System;Tendon structure;Testing;Training;Training Activity;trait;Translations;vibration;Vision;Visual;visual feedback;visual motor

PROJECT_TITLE: Multi-modal sensory feedback mechanisms of fine and gross motor control in autism spectrum disorders

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Diabetes and metabolic diseases are a global and national burden for health care with a high death toll. Hormones produced by intestinal endocrine cells exert important regulatory actions in metabolism and glucose homeostasis. The studies proposed by the candidate seek to investigate the modulatory effects of a retinoid- related protein on intestinal endocrine cell homeostasis and insulinotropic hormone production and will provide physiological insights that may help harness these cells’ therapeutic potential.

PI_NAMEs: CALDERON, ROSSANA M (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Ablation;absorption;Affect;Age;Appetite Regulation;Area;blood glucose regulation;Body Weight;career;career development;Cell Count;Cell Death;Cell Differentiation process;Cell Lineage;Cell Physiology;Cell Proliferation;cell type;Cells;Cellular biology;Cessation of life;Classification;Complex;Data;design;Desire for food;Development;Diabetes Mellitus;Diet;dietary;differential expression;Disease;Down-Regulation;Endocrine;Endocrine Glands;Endocrinologist;Enterobacteria phage P1 Cre recombinase;Enterocytes;Enteroendocrine Cell;Environment;experimental study;functional genomics;Gastric Inhibitory Polypeptide;gastric inhibitory polypeptide receptor;Gastrointestinal tract structure;Gene Expression;Gene Expression Regulation;Generations;Genes;glucagon-like peptide 1;glucagon-like polypeptides;Glucose;Goals;Goblet Cells;Health;healthcare burden;High Fat Diet;Homeostasis;Hormonal;Hormone secretion;Hormones;Human;Human body;In Vitro;in vivo;incretin hormone;insight;Insulin Resistance;insulin secretion;intestinal epithelium;Intestines;Islets of Langerhans;Knockout Mice;Knowledge;L Cells;Lead;Learning;Measures;Mentorship;Metabolic;Metabolic Diseases;Metabolism;migration;Molecular Biology;mouse model;Mucous Membrane;multidisciplinary;Mus;novel;Organoids;Paneth Cells;Pathway interactions;Phase;Physiological;Physiology;Population;Production;Proliferating;Proteins;Publishing;Regulation;Reporting;research data dissemination;Research Proposals;Resources;response;Retinoids;Retinol Binding Proteins;Role;Signal Pathway;Site;skills;Small Intestines;Technical Expertise;Therapeutic;three dimensional cell culture;trafficking;Training;Training Programs;transcription factor;Transcription Factor AP-1;Transcriptional Regulation;transcriptomics;Transgenic Mice;translational scientist;Universities;Villus;Vitamin A;Weight;Writing

PROJECT_TITLE: Modulatory effects of a retinoid-related protein on intestinal endocrine cells

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: LEXINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Chlamydia trachomatis is a common human pathogen, yet a full understanding of how Chlamydia causes disease is lacking. This proposal contains work designed to create a transposon system to enable mutagenesis capable of supporting forward genetic analyses. This capability has proven essential in other bacterial systems to fully comprehend pathogenesis.

PI_NAMEs: FIELDS, KENNETH A (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Address;Alleles;Attenuated;Bacteria;Biology;Cell Culture Techniques;Cells;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Collection;comparative;Complex;Coupled;Couples;Data;design;Detection;Development;Disease;Dissection;DNA Transposable Elements;Engineering;Essential Genes;Female;fitness;Fluorescence;forward genetics;Future;gene product;Gene Silencing;Generations;Genes;Genetic;genetic analysis;genetic approach;genetic manipulation;Genetic Techniques;Genome;genome sequencing;genome-wide;Goals;Growth;Health;Hela Cells;Host Defense Mechanism;Human;human pathogen;Individual;Infection;innovation;intracellular parasitism;Investigation;Libraries;loss of function mutation;Maintenance;Mediating;Molecular;Mutagenesis;mutant;novel;obligate intracellular parasite;Organism;pathogen;Pathogenesis;Phase;Phenotype;Plasmids;Preventive vaccine;Production;Productivity;Reagent;Recombinants;Replication Origin;Replicon;Reporting;Reproducibility;reproductive fitness;Resources;reverse genetics;screening;System;Techniques;Testing;tool;Toxic effect;Transposase;user-friendly;Virulence;whole genome;Work

PROJECT_TITLE: Saturating transposon mutagenesis for Chlamydia

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: Bethesda

ORG_NAME: ASSOCIATION /PUBLIC HEALTH LABORATORIES

PHR: FOA PAR-23-072 Regulatory Science Track of the 2024 APHL Annual Conference  Project Narrative The new Regulatory Science Track of the 2024 APHL Annual Conference will enable leaders, scientists, policy makers, regulators, and their partners to share issues, trends and best practices driving public health. Information presented will help scientists in their efforts to submit high-quality data for regulatory action, improve investigations that rely on food testing and human illness data, and reduce foodborne illnesses and deaths overall. This purpose aligns with ORA's commitment to building laboratory capacity and capability and integrating the food testing community with regulatory and public health partners.

PI_NAMEs: SHEA, SHARI  (contact)

PROGRAM_OFFICER_NAME: WEBB, SUZANNE

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 ORA-J (01)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Wound Healing and Care

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE Community-based drug checking (CBDC) has the potential to identify emerging substances like xylazine (a dangerous adulterant not approved for use in humans) in the illicit drug market in real time and serve as point of care with actionable responses and referrals to treatment and services; however, there is limited information on the use of CBDC in rural settings. Minnesota legalized all drug paraphernalia in 2023, and the state provided funding to syringe service programs (SSPs) to purchase Fourier-transform infrared spectroscopy equipment, xylazine testing strips, and wound care kits. Through collaboration with an SSP that has a delivery area classified as rural and includes two American Indian / Native American tribal reservations, we will examine use of their CBDC program using the Behavioral Model for Vulnerable Populations as a guiding framework. The 24-month mixed-methods study will examine feasibility and acceptability of the CBDC program to detect xylazine through surveys with program participants and interviews with staff—with those whose drugs test positive for xylazine recruited to complete a qualitative interview on use and health effects— and the prevalence of xylazine calculated among the illicit drug samples tested with dissemination to harm reduction and public health stakeholders prioritized.

PI_NAMEs: RAY, BRADLEY  (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: acceptability and feasibility;Adult;Age;Alaska Native;Alaska Native population;Alaska Native reservation;American Indian Population;American Indians;Amputation;Area;Back;Behavioral;Behavioral Model;Black race;central database;Cessation of life;Classification;Collaborations;Communities;Dangerousness;Data;Data Set;Death Rate;Disparity;drug market;drug testing;Drug user;Equipment;experience;Fentanyl;Funding;Future;Grant;Harm Reduction;Health;Human;Illicit Drugs;implementation facilitators;implementation science;improved;Indian reservation;Individual;infrared spectroscopy;Intake;Intervention;Interview;Investigation;Legal;Literature;Measures;Methods;Minnesota;Native American Tribe;Needle-Exchange Programs;Not Hispanic or Latino;Overdose;overdose death;Paper;Participant;Pattern;Perception;Pharmaceutical Preparations;Philadelphia;point of care;Population;Prevalence;Process;programs;Public Health;Puerto Rico;racial disparity;recruit;Research;Research Methodology;response;Rural;Rural Community;rural setting;Sampling;sedative;Services;Skin Tissue;skin ulcer;Source;Spectroscopy, Fourier Transform Infrared;Structure;suburb;Surveys;synthetic opioid;Techniques;Technology;test strip;Testing;Time;Training;tribal community;United States;United States National Institutes of Health;Variant;Vulnerable Populations;Withdrawal Symptom;wound;wound care;Xylazine

PROJECT_TITLE: Community Mitigation Against Xylazine

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Prevention;Substance Misuse;Tobacco

ORG_CITY: CHICAGO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Cigarette smoking and nicotine dependence are the major cause of preventable death in the United States. A potent driver of relapse to smoking are places (e.g., bars or coffee shops) where the effects of nicotine were previously experienced. The proposed research aims to understand the neural basis of these drug-place associations by determining how the hippocampus and nicotinic receptors regulate learning in a mouse model, findings that will potentially lead to novel treatments to prevent relapse.

PI_NAMEs: KRISHNAN, SEETHA LAKSHMI  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Address;Alleles;Animal Behavior;antagonist;awake;Behavior;Behavioral Model;Behavioral Paradigm;Binding;Calcium;Cells;Cessation of life;cigarette smoking;Coffee;Computer Analysis;computerized tools;conditioning;Data Set;design;Development;Dorsal;Drug Addiction;drug relapse;Drug usage;Enterobacteria phage P1 Cre recombinase;Environment;Exhibits;experience;experimental group;Extinction;Foundations;Funding;Genetic;Genetic Techniques;Goals;Head;Hippocampal Formation;Hippocampus;Image;Imaging Techniques;Individual;Knockout Mice;Knowledge;Learning;Mediating;Memory;memory process;memory retrieval;Mentors;Mentorship;mouse model;Mus;neural;neurobiological mechanism;Neurobiology;neuromechanism;Neurons;Nicotine;nicotine craving;Nicotine Dependence;nicotine reward;Nicotinic Receptors;novel;novel therapeutics;optical imaging;Oral;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Phase;Population;prevent;preventable death;Prevention strategy;programs;receptor;receptor function;Relapse;relapse prevention;Research;Research Personnel;Retrieval;Rewards;Role;Running;skills;Smoke;Smoking;smoking addiction;smoking cessation;Smoking Cessation Intervention;social;Substance Use Disorder;System;Techniques;Testing;Time;tool;Training;two-photon;United States;Ventral Tegmental Area;Viral Vector;virtual reality;Water

PROJECT_TITLE: Hippocampal memory mechanisms in nicotine relapse

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Genetics;Lung;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Plasticity is a key property of the neural system controlling breathing, and is an important compensatory mechanism for disease or injury. Acute intermittent hypoxia triggers respiratory plasticity, and has emerged as a promising neurotherapeutic to preserve/restore breathing in devastating clinical disorders such as spinal cord injury and ALS; thus, understanding how specific factors affect individual responses to this promising treatment is a key ‘next-step’ in finding biomarkers to assure success (or failure) of clinical trials. I propose experiments to investigate the specific roles of the APOE4 gene and inflammation in motor neuron-microglia interactions that regulate respiratory motor plasticity.

PI_NAMEs: MARCIANTE, ALEXANDRIA  (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Acceleration;Acute;Adenosine;Affect;Agonist;Alleles;Alzheimer's Disease;apolipoprotein E-3;apolipoprotein E-4;Apolipoproteins;Automobile Driving;Award;Biological Markers;Breathing;career;Cell model;Cell Nucleus;Cells;Central Nervous System Diseases;Clinical;Clinical Trials;Communication;Compensation;CX3CL1 gene;Data;Dedications;Dependence;design;Disease;experimental study;Failure;Female;Foundations;Fractalkine;fractalkine receptor;Genes;Genetic;genetic manipulation;Genetic study;Goals;Hippocampus;Human;Hypoxia;Impairment;improved;Individual;individual response;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;interdisciplinary approach;Knock-in;Knowledge;Life;Lipopolysaccharides;Lung;Lung Diseases;lung injury;male;Mentors;Microglia;Modality;Modeling;Molecular Analysis;Molecular Target;Motor;Motor Neurons;Motor output;Nerve Degeneration;nerve injury;Nervous System Trauma;neural;neural network;Neuroglia;neuroinflammation;Neuronal Plasticity;Neurons;neuroregulation;Neurosciences;neurotransmission;novel;Pathway interactions;personalized intervention;Persons;Phase;Phase Transition;preservation;Productivity;programs;Property;Rattus;receptor;Regulation;Research;Research Personnel;Respiration;respiratory;Respiratory Diaphragm;Respiratory Failure;Respiratory physiology;response;Rest;Rodent;Role;Scientist;Serotonin;Signal Transduction;skills;Specificity;Spinal;Spinal cord injury;Sprague-Dawley Rats;Study models;success;Synaptic plasticity;System;systemic inflammatory response;Technical Expertise;Testing;Therapeutic;Time;Tissues;TLR4 gene;Training;Translations;Treatment Efficacy;Variant;virtual;young adult

PROJECT_TITLE: Rest/Active Phase Specificity of APOE4 and Inflammation on Respiratory Plasticity


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Human Genome;Lung;Machine Learning and Artificial Intelligence;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Large-scale human studies have pinpointed thousands of regions in the human genome that are associated with susceptibility to diseases such as type 2 diabetes, asthma, and cardiovascular disease. Understanding how genetic variants are linked to specific disease processes is needed to establish effective, novel therapies. The goal of this project is to develop and apply new tools to map out gene regulatory networks and connect their activities to disease-associated genetic variation.

PI_NAMEs: TOVAR, ADELAIDE E (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 3-Dimensional;Address;Architecture;Asthma;ATAC-seq;Automobile Driving;Beta Cell;Binding;Binding Sites;Biological;Biological Assay;candidate identification;Cardiovascular Diseases;career;Catalogs;Cell Line;cell type;Cells;Chromatin;Code;combinatorial;Complex;CRISPR screen;cytokine;Data;data modalities;Data Set;Development;Diabetes Mellitus;Dimensions;Disease;disease phenotype;disorder risk;Dissection;Distal;DNA Binding Domain;early onset;Enhancers;Etiology;Fellowship;functional genomics;gene environment interaction;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic Diseases;Genetic Screening;genetic signature;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic locus;genomic profiles;Genomic Segment;Genomics;Goals;Heritability;histone modification;Human;Human Genetics;Human Genome;human genomics;Individual;Inflammatory;insight;Islets of Langerhans;Knowledge;Learning;lens;Link;Lung;Lung Diseases;Machine Learning;Maps;Mediating;Mendelian disorder;Mentors;Mentorship;Methods;Modeling;mutation screening;non-genetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutics;Organoids;Pathogenesis;Pathway interactions;Phase;Phenotype;Postdoctoral Fellow;Predisposition;Process;programs;Proteins;Regulation;Regulatory Element;Reporter;Repression;Research;respiratory;Respiratory Disease;Signal Transduction;skills;Stimulus;Structure;System;Techniques;Technology;Testing;therapeutic target;Thyroid Diseases;Thyroid Gland;Tissues;tool;Training;trait;transcription factor;transcriptome sequencing;Untranslated RNA;Variant

PROJECT_TITLE: Using the continuum of genetic causality to investigate trans regulatory mechanisms.

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (MK)]


NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE: Myelodysplastic syndrome (MDS) is a common blood disorder in which the bone marrow fails to produce enough blood cells, resulting in anemia, infection and bleeding. Although we know what genetic changes (mutations) cause MDS, the precise mechanisms that cause MDS are still unclear, and this has prevented development of effective therapies. This proposal seeks to improve our understanding of molecular pathways of MDS, especially those affecting processing of ribonucleic acid (RNA); it is hoped that this work will help develop novel therapies and offer a path to cure for patients with MDS.

PI_NAMEs: BODDU, PRAJWAL  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: 3-Dimensional;Accounting;Acute;Address;Adult;Advisory Committees;Affect;Alternative Splicing;Anemia;Architecture;Binding;Biochemical;Biology;Blood Cells;Bone Marrow;Bone marrow failure;bone marrow failure syndrome;career;career development;Chromatin;Chromatin Structure;Clinical;Clonal Evolution;Complement;Complex;Data;Data Set;Defect;demethylation;density;design;Development;Development Plans;Disease;driver mutation;Dysmyelopoietic Syndromes;effective therapy;Epigenetic Process;epigenetic therapy;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genome;genome-wide;Global Change;HDAC2 gene;Hematological Disease;Hematopoiesis;Hemorrhage;Higher Order Chromatin Structure;Histone Deacetylase;Histones;Impairment;improved;Induced Mutation;Infection;insight;Investigation;investigator training;K-Series Research Career Programs;Kinetics;Knowledge;Link;Mentors;Mentorship;Modeling;Modification;Molecular;mouse model;mRNA Precursor;mutant;Mutation;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Oncogenes;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Physicians;Polymerase;Positive Transcriptional Elongation Factor B;preclinical study;premature;prevent;Principal Investigator;Process;promoter;protein degradation;Protein Isoforms;Proteins;Recurrence;Regulation;Regulator Genes;Research;response;Reverse Transcription;RNA;RNA Splicing;Role;Sampling;Scientist;Shapes;Spliceosome Assembly Pathway;Spliceosomes;SRSF2 gene;System;targeted treatment;Testing;Therapeutic;therapeutic target;Training;Training Programs;Tumor Suppressor Proteins;Universities;Work

PROJECT_TITLE: Therapeutic Targeting of Transcription-Driven Epigenetic Defects in SF3B1 Mutant Myelodysplastic syndromes (MDS)

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: ORLANDO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

PHR: Project Narrative Tuberculosis (TB) exerts a global impact on public health, causing nearly 10 million new infections and 1.5 million deaths annually. There remains an urgent need for new anti-TB drugs and many genetically validated drug targets remain to be exploited. In this project, we seek to optimize a novel type of cell wall synthesis inhibitor with the goal of developing a new candidate antibiotic for the treatment of TB.

PI_NAMEs: ROHDE, KYLE H (contact);SCHOMAKER, JENNIFER MARIE

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: 2019-nCoV;Acute;Address;Anabolism;analog;Antibiotic Therapy;antibiotic tolerance;Antibiotics;antimicrobial;Antitubercular Antibiotics;Bacillus;Bacteria;bactericide;Biochemical;Biological Availability;cell type;Cell Wall;Cells;Cessation of life;Chronic;Clinical;Clinical Trials;cost;COVID-19 impact;COVID-19 pandemic effects;CRISPR interference;Cytolysis;Development;Disease;Docking;drug candidate;Drug Combinations;drug discovery;Drug Kinetics;Drug resistance;Drug resistant Mycobacteria Tuberculosis;Drug Targeting;efficacy study;Ensure;Enzymes;Equilibrium;Evaluation;extensive drug resistance;extracellular;Extreme drug resistant tuberculosis;Future;Genetic;genome sequencing;genotoxicity;Genus Mycobacterium;Goals;Granuloma;Heterogeneity;in silico;In Vitro;in vivo;in vivo Model;Infection;Infectious Agent;inhibitor;insight;isoniazid;knock-down;Knowledge;Lead;lead optimization;Lesion;Logistics;Macrophage;Mammalian Cell;Metabolic;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Multidrug-Resistant Tuberculosis;Multiple drug resistant Mycobacteria Tuberculosis;mutant;mycobacterial;Mycobacterium tuberculosis;Mycolic Acid;Natural Products;novel;novel therapeutics;Oral;pandemic disease;Patients;Performance;Periodicity;Permeability;Persons;Phagosomes;Pharmaceutical Preparations;pharmacologic;Phenotype;pre-clinical;Predisposition;Property;Public Health;Regimen;Reporting;Research;Resistance;Resistance development;resistant strain;Route;Safety;screening;Series;side effect;Specificity;standard of care;stem;Structure-Activity Relationship;success;sulfamate;synergism;Synthesis Chemistry;Testing;Treatment Protocols;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Validation;Variant;Virulence;whole genome;Work

PROJECT_TITLE: Optimization of novel inhibitors of mycolic acid synthesis as TB drug candidates.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-T (90)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project narrative Loss of muscle mass occurs in various diseases such as sarcopenia, cancer cachexia, amyotrophic lateral sclerosis, leading to poor prognosis and increased mortality rate. There is an urgent need to understand the requirements for maintaining muscle mass and to develop therapeutic treatments for muscle disease. Our research explores the role of the transcription factor Maf in repressing muscle atrophy to develop new therapeutic strategies against muscle mass loss.

PI_NAMEs: DOS SANTOS, MATTHIEU  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Affect;Aging;aging population;Amyotrophic Lateral Sclerosis;Anabolism;ATAC-seq;Atrophic;Award;Cachexia;Calcineurin;Cancer Cachexia;Catabolism;Cell Culture Techniques;Cell Nucleus;Classification;Co-Immunoprecipitations;Data;Death Rate;Defect;Dependovirus;Disease;disease model;effective therapy;Elderly;Energy Metabolism;Equilibrium;Event;experimental study;Fasting;Fiber;Foundations;FRAP1 gene;Gene Expression;gene repression;gene therapy;Genes;Genetic Transcription;global health;Glucocorticoids;glycogen synthase kinase 3 beta;Growth;Human body;IGF1 gene;in vivo;Injections;insight;Investigation;Knowledge;Locomotion;Mass Spectrum Analysis;Measures;Mentors;Metabolic;Metabolism;Modeling;Molecular;mortality;mouse model;multiple omics;Muscle;muscle form;Muscular Atrophy;Myopathy;Neuromuscular research;novel;novel therapeutic intervention;Organ;Outcome;overexpression;Pathway interactions;Patients;Persons;Phase;Play;Population;prevent;Prevention;Prognosis;programs;Property;protective effect;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Quality of life;Regulation;Repression;Research;Research Personnel;Research Proposals;Role;sarcopenia;Shapes;Signal Pathway;Skeletal Muscle;skeletal muscle wasting;skills;Structure;Testing;Therapeutic;Time;Training;transcription factor;Transcription Repressor;transcriptome sequencing;transcriptomic profiling;Work

PROJECT_TITLE: Characterization of Maf function in muscle atrophy

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Psychological stress is associated with elevated risk for negative mental and physical health outcomes, yet we have a limited understanding of the brain circuits and brain-body pathways that are a) implicated in this risk and b) can be modified by interventions in humans. In this K01 application, the applicant proposes training goals in 1) clinical affective neuroscience, 2) transcranial magnetic stimulation methods, and 3) human experimental study design, which will enable the applicant to complete the proposed research and transition to an independent investigator focused on characterizing and manipulating brain-body interactions in healthy and clinical populations. This study will manipulate brain activity in a circuit implicated in stress processing and test the effect of this manipulation on brain and emotional responses to psychological stress in midlife adults.

PI_NAMEs: KRAYNAK, THOMAS EDWARD (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acute;acute stress;Address;Adult;Affect;Affective;affective neuroscience;Age;Amygdaloid structure;Anterior;Anxiety;Anxiety Disorders;Atherosclerosis;Behavior;Behavioral;Brain;brain based;brain circuitry;Brain imaging;Brain region;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Characteristics;cingulate cortex;Clinical;cohort;collaborative environment;Cone;cost;Cues;design;Development;Dorsal;electric field;Emotional;experimental study;Exposure to;Functional Magnetic Resonance Imaging;Future;Goals;Health;Homosynaptic Depression;Human;Hypertension;Individual;Individual Differences;Insula of Reil;Intervention;K-Series Research Career Programs;Lateral;Link;Mediating;Mediator;Mental disorders;Mental Health;Metabolic;Methodology;Methods;midbrain central gray substance;middle age;mind body interaction;Modeling;Moods;multimodality;negative affect;neurobiological mechanism;Neurobiology;neuroimaging;neuromechanism;Neuronavigation;neuroregulation;novel;Observational Study;Outcome;Participant;Pathogenicity;Pathway interactions;Patient Self-Report;Peripheral;Phenotype;physical conditioning;Physiological;Physiology;Population;Postdoctoral Fellow;Prefrontal Cortex;Process;Protocols documentation;Psychiatry;Psychological Stress;psychological stressor;Psychopathology;Psychophysiology;Reporting;Research;Research Design;Research Personnel;response;Risk;Stress;Stressful Event;stressor;Stroke;Structure;symptomatology;Testing;Training;Transcranial magnetic stimulation;Translating;Universities;Work

PROJECT_TITLE: Neuromodulation of brain and emotional responses to psychological stress

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Infectious Diseases;Malaria;Networking and Information Technology R&D (NITRD);Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE While genomic data can provide an invaluable source of information to understand pathogen evolution, identify patterns of transmission, and characterize phenotypes such as drug resistance and immune escape, the complex biology and infection dynamics of eukaryotic pathogens have limited the use of these data. Leveraging recent laboratory advances in targeted amplicon sequencing that are changing the landscape of data availability, we propose to develop an ecosystem of integrated analysis tools to facilitate research using these data.

PI_NAMEs: GREENHOUSE, BRYAN R (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: 2019-nCoV;Address;American;Automobile Driving;Bacteria;base;Bioinformatics;bioinformatics pipeline;Biological;Biology;Chagas Disease;Clinical Data;cloud platform;Communities;Complex;Computer software;computerized tools;Data;Data Analyses;data reuse;data standards;Data Storage and Retrieval;Development;direct application;Disease;disorder control;Documentation;Drug resistance;Ecosystem;Education and Outreach;Educational workshop;Ensure;epidemiologic data;Epidemiology;Evolution;Exhibits;Feedback;Filariasis;Galaxy;Gene Frequency;Generations;Genetic;genetic analysis;Genetic Recombination;Genetic Research;Genetic Variation;Genome;genomic data;Genomics;Goals;HIV;Human;Hygiene;Immune;improved;Individual;Infection;Influenza;innovation;interest;interoperability;Laboratories;laboratory development;Leishmaniasis;Malaria;malaria infection;meetings;Metadata;method development;Methods;Morbidity - disease rate;mortality;Motivation;Nature;Ontology;Organism;Outcome;Output;outreach;Parasites;pathogen;Pattern;Performance;Phenotype;Plasmodium;Plasmodium falciparum;Population;Population Genetics;portability;Process;Productivity;Public Health;Reproducibility of Results;Research;Research Personnel;Resolution;Resources;Sampling;Schistosomiasis;Scientist;Societies;software development;Software Tools;Source;Standardization;Statistical Data Interpretation;Structure;targeted sequencing;Techniques;tool;Translating;transmission process;Tropical Medicine;uptake;Validation;Variant;Viral;Virus;Work

PROJECT_TITLE: Data and analysis ecosystem for eukaryotic pathogen targeted sequencing

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SB-X (M1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Rural Health;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: DUKE UNIVERSITY

PHR: Title: Building a Harmonized Village Network Data Resource for Realistic Disease Transmission Models PROJECT NARRATIVE To understand how policy, behavior and disease interact to generate outbreaks, social scientists need models that can accurately capture the myriad factors driving real-life epidemics, but current data and modeling practices perform poorly and fail to meet this need, largely due to insufficient data support and heterogenous modeling practices. Collective science – pooling data and tools from multiple investigators – is a proven method to amplify scientific investment for public good, allowing researchers greater insights across larger and more diverse domains. This project will (1) develop a secure-but-shareable repository of village and rural networks to serve as a test-bed for disease simulation modeling; (2) expand tools for network simulation to allow modeling of multiple types of pathogens, disease responsiveness, information flow, and policy interventions; and (3) compare disease-responsive behavior models across multiple contexts to identify how network structure moderates behavioral effects on epidemic size.

PI_NAMEs: MOODY, JAMES  (contact)

PROJECT_TERMS: Adopted;Agreement;archived data;Archives;Automobile Driving;base;Beds;Behavior;behavior test;Behavior Therapy;Behavioral;Censuses;Characteristics;Code;cohesion;Communities;Community Networks;community science;cost;Data;data archive;Data Collection;data harmonization;data hosting;data modeling;Data Pooling;data resource;Data Set;data sharing;Data Storage and Retrieval;data structure;Deposition;Discipline;Disclosure;Disease;disease model;Disease Outbreaks;disease transmission;disinformation;diverse data;Electronic Mail;Epidemic;epidemiological model;experimental study;flexibility;Foundations;Future;future outbreak;future pandemic;Heterogeneity;improved;Infection;insight;Institutional Review Boards;interest;Intervention;Investments;Life;Link;Mathematics;Methods;Modeling;models and simulation;Network-based;online repository;open-access repositories;pathogen;Pattern;Persons;Phase;Policies;Population;Positioning Attribute;Preparation;preservation;Process;Production;Relaxation;repository;Reproducibility;Research;Research Personnel;Resources;response;Risk;Running;Rural;Rural Community;rural setting;Sampling;Science;Scientist;Secure;Shapes;simulation;social;sociodemographics;Structure;Testing;text searching;Time;tool;transmission process;Universities;Validation;web page;Work;zoonotic spillover

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Project Narrative: Public Health Relevance The proposed research is relevant to public health because it will increase access to evidence-based mental health resources for hundreds of Latino families who need intervention but for whom myriad barriers impede their access. Furthermore, a significant step will have been taken toward providing much-needed mental health resources to Latino parents following the largest global health crisis of the modern era. The project aligns with NIMH's strategic plan to develop innovative service delivery models to improve the outcomes of mental health services received in underserved communities through technology-mediated services that have the potential to improve access to and effectiveness of evidence-based interventions for adolescent mental health problems.

PI_NAMEs: COBB, CORY LAMOINE (contact);MARTINEZ, CHARLES R

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Address;adolescent mental health;adverse outcome;Affect;behavioral health;behavioral outcome;Child;Child Care;Child Mental Health;Child Rearing;Chronic;Clinical;Communities;community partners;Complex;cost;COVID-19;COVID-19 disparity;COVID-19 impact;COVID-19 pandemic;Death Rate;Development;digital;digital mental health;digital technology;Discipline;Discrimination;Economics;Effectiveness;effectiveness trial;effectiveness-implementation RCT;efficacy evaluation;empowerment;Environment;ethnic identity;Ethnic Population;evidence base;Evidence based intervention;experience;Exposure to;Face;Failure;Family;Feedback;Feeling suicidal;follow-up;Foundations;Funding;Gender;global health;health care settings;health disparity;health equity;Health Promotion;Health Resources;Health Services Accessibility;Health Technology;Healthcare Systems;High Prevalence;high risk;Hybrids;Imprisonment;Improve Access;improved;improved outcome;infection rate;innovation;Intervention;intervention refinement;Language;Latino;Latino Population;Loneliness;Manuals;Mediating;Mental Depression;mental development;Mental Health;Mental Health Services;Minority Groups;Modernization;Monitor;National Institute of Mental Health;Nonprofit Organizations;online version;Outcome;outcome disparities;pandemic disease;parental role;parenting intervention;Parents;Population;prevent;Preventive;preventive intervention;Problem Solving;Process;programs;psychosocial;Public Health;public health priorities;public health relevance;racial population;Reporting;Research;Risk;scale up;Schools;Service delivery model;Services;Severity of illness;Social Environment;social stigma;Socioeconomic Factors;Strategic Planning;Stress;stressor;substance use;Suicide attempt;suicide rate;Technology;Testing;Texas;Time;Training Programs;Treatment Cost;underserved community;Underserved Population;United States National Institutes of Health;uptake;Work;Youth

PROJECT_TITLE: The Latino Youth and Family Empowerment Study – III (LYFE-III): Bringing to Scale a Culturally-Adapted and Evidence-Based Intervention for Latino Families

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Lung;Pulmonary Hypertension;Rare Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Pulmonary arterial hypertension (PAH) is a deadly under-recognized disease characterized by high blood pressure in the lungs and right heart failure. While several medicines are used to treat PAH, none can cure this disease and none are aimed at helping right heart function. We propose to serve as the Data Coordinating Center for a randomized clinical trial testing whether the drug empagliflozin, classified as a sodium glucose co- transporter 2 (SGLT-2) inhibitor, will improve right heart function and other outcomes in patients with PAH.

PI_NAMEs: GASSMAN, JENNIFER J (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Achievement;Adherence;Administrative Personnel;Adverse event;Archives;biobank;Biological;Biometry;Blinded;Brain natriuretic peptide;Cardiac;cardiac magnetic resonance imaging;Case Report Form;Cholesterol;Classification;Clinic;Clinical;clinical imaging;clinical research site;Code;Communication;Communities;Data;Data Analyses;Data Collection;Data Coordinating Center;Data Files;data quality;Database Management Systems;Databases;Death Rate;design;Development;Disease;distributed data;Doctor of Philosophy;Documentation;Echocardiography;EFRAC;Eligibility Determination;Ensure;Environment;experience;Feedback;follow-up;Glucose;Goals;Health Personnel;heart function;heart imaging;High Density Lipoproteins;Human Resources;Hypertension;Image;image processing;imaging facilities;improved;Information Dissemination;inhibitor;Institutional Review Boards;Knowledge;Leadership;Lipids;Logistics;Low-Density Lipoproteins;Lung;Magnetic Resonance;Manuals;Manuscripts;Measurement;Measures;Medical;Medicine;meetings;member;Metabolic;Methodology;Monitor;N-terminal;National Heart, Lung, and Blood Institute;operation;Outcome;Participant;Patients;Pharmaceutical Preparations;Phase;phase II trial;phase III trial;phenomics;Phenotype;physical conditioning;Placebo Control;Placebos;Play;primary endpoint;Procedures;Process;programs;Protocols documentation;Publications;pulmonary arterial hypertension;Pulmonary Hypertension;pulmonary vascular disorder;Quality Control;Quality of life;Randomized;randomized, clinical trials;recruit;Reporting;Reproducibility of Results;Research;Research Design;Research Personnel;Resolution;response;right ventricular failure;Right Ventricular Function;Risk;Role;Safety;sample archive;sample collection;Sample Size;Sampling;Schedule;secondary endpoint;Secure;SF-36;Site;Sodium;sound;Specific qualifier value;Specimen;statistical center;Statistical Data Interpretation;Subconscious;symporter;System;Testing;Time;Training;transmission process;trial design;Triglycerides;United States National Institutes of Health;Ventricular Ejection Fractions;virtual;Walking;Writing

PROJECT_TITLE: Master - 2/2 Empaglifozin To Improve Right Ventricular Function in Pulmonary Arterial Hypertension

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR (MA)]


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: PATHOLOGY

PHR: Project Narrative High-throughput Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) has become a fundamental method for investigating B cell and T cell adaptive immune responses. We developed nf-core/airrflow (AIRRflow), a high-throughput, scalable analysis workflow using the Immcantation Framework that facilitate AIRR-seq data processing in high-performance clusters and cloud infrastructure. Through novel features that enable the integrated analysis of large-scale AIRR-seq datasets and improve interoperability with public databases and downstream analysis tools, we aim to make AIRRflow an even more useful tool for the infectious and immune- mediated disease community.

PI_NAMEs: GABERNET, GISELA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Address;analysis pipeline;B-Lymphocytes;base;Cloud Computing;cluster computing;Code;cohort;Collaborations;Collection;Communication;Communities;community engagement;Community Surveys;Computer software;computerized data processing;Data;Data Analyses;data ecosystem;data integration;data reuse;Data Set;Databases;Disease;Ecosystem;Ensure;Epitopes;Event;FAIR principles;Feedback;Goals;hackathon;High Performance Computing;high throughput analysis;Immune;Immunoglobulin Somatic Hypermutation;Immunologic Receptors;improved;Individual;Infrastructure;International;interoperability;Length;Lymphocyte;Machine Learning;machine learning model;Maintenance;Mediating;meetings;member;Metadata;Methods;Modality;National Institute of Allergy and Infectious Disease;novel;open source;parallelization;Patients;Performance;public database;Pythons;receptor;reconstruction;Reporting;repository;Reproducibility;Research;Research Personnel;Resources;response;Sampling;Sequence Read Archive;single-cell RNA sequencing;software development;Specificity;Surveys;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte;task analysis;Technology;Testing;tool;Training;transcriptome sequencing;Translating;United States National Institutes of Health;usability;vector;Visualization;Work

PROJECT_TITLE: Large-scale integrated data analysis of lymphocyte receptor repertoires with workflows


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Precision Medicine;Rare Diseases;Skin Cancer

ORG_CITY: BALTIMORE

ORG_DEPT: DERMATOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Some patients with mycosis fungoides (MF), a skin cancer, will progress to late-stage disease with involvement beyond the skin and a higher mortality risk. This study will investigate the subtypes and the location of cancer- associated fibroblasts (CAFs) responsible for immune evasion of MF tumor cells in the skin of diverse patient populations. Results obtained here will provide insights into the role of the tumor microenvironment in the progression of MF and identify potential targets for more direct personalized therapies to improve overall survival.

PI_NAMEs: JOHNSON, COURTNEY MICHELE (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Age;anti-tumor immune response;biobank;Biological Markers;Biology;biomarker identification;Biomedical Engineering;black patient;Black race;Blood;cancer cell;cancer classification;cancer gene expression;cancer site;cancer subtypes;candidate identification;career;career development;Cell Line;Cells;Clinical;Coculture Techniques;Communication;Complex;Computer Analysis;Core Facility;Cutaneous;Cutaneous Lymphoma;cytokine;Data;demographics;density;Dermatology;Detection;Development;Development Plans;deviant;Diagnosis;Disease;disease diagnosis;disease prognosis;Disease Progression;Dissociation;Elements;Environment;Fibroblasts;Gene Expression;Gene Expression Profile;Genetic Markers;Genomics;high risk;Hispanic;Homing;IL16 gene;IL4 gene;Immune;Immune Evasion;Immune system;Immune System Diseases;immune system function;Immunohistochemistry;Immunophenotyping;improved;Incidence;Individual;Indolent;Infrastructure;insight;interest;Interleukin-16;Ligands;Location;lymph nodes;Malignant - descriptor;Malignant Neoplasms;Mentors;Methods;Minority Groups;Molecular;mortality risk;Mycosis Fungoides;neoplastic cell;novel;Outcome;Pathogenesis;Pathway interactions;patient biomarkers;patient population;Patients;personalized medicine;Phase;Population;Prognosis;progression risk;Proliferating;Race;receptor;Research Training;Resolution;risk stratification;RNA;RNA analysis;Role;Sample Size;Sampling;single cell analysis;single-cell RNA sequencing;skills;Skin;Skin Cancer;Skin Neoplasms;Skin Tissue;Specific qualifier value;Staging;Statistical Data Interpretation;Statistical Models;Stromal Cell-Derived Factor 1;survival outcome;Survival Rate;T-Lymphocyte;Techniques;Testing;therapeutic target;Tissue-Specific Gene Expression;Training;transcriptome sequencing;transcriptomics;Treatment Protocols;tumor;Tumor Cell Invasion;tumor microenvironment;Tumor Suppression;TWIST1 gene;Viscera;Work

PROJECT_TITLE: Investigating the Role of Cancer-Associated Fibroblasts in Immunodetection of Mycosis Fungoides


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Neurosciences;Pediatric;Prevention;Sleep Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Our research team has shown a link between poor sleep health and late circadian timing with cardiometabolic dysfunction in adolescents with type 1 diabetes (T1D). Our central hypothesis is that that cardiometabolic dysfunction associated with T1D can be reduced by improving sleep health and circadian timing. The overall objective of the current proposal is to use a 1-month intervention with known chronobiotic tools, PM melatonin and AM bright light, in conjunction with extended sleep opportunity, as a mechanistic probe to understand changes in cardiometabolic outcomes (insulin sensitivity, glycemic control, and aortic stiffness) and physiologic mechanisms in adolescents with T1D using a combined free-living and in-laboratory paradigm.

PI_NAMEs: SIMON, STACEY LYNN (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: adipokines;Adolescence;Adolescent;Age;Aorta;arterial stiffness;Attention;Beds;Behavior;Behavior Therapy;Behavioral;Behavioral Mechanisms;Blood Pressure;Blood Vessels;C-reactive protein;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;circadian;Circadian Dysregulation;Clinical Trials Design;comparison control;comparison intervention;Diastolic blood pressure;Dimensions;Dose;Functional disorder;Glucose Clamp;glycemic control;Health;high body mass index;Hormones;Hour;Hydrocortisone;Hyperinsulinism;improved;improvement on sleep;Inflammation;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Intervention;Laboratories;Leptin;Light;Link;Magnetic Resonance Imaging;Measures;Mediator;Melatonin;Methods;Moods;Morbidity - disease rate;mortality;novel therapeutics;Obesity;Outcome;Persons;Physiological;poor sleep;Positioning Attribute;randomized, clinical trials;Recommendation;Research;research study;response;Sampling;Self Management;Sleep;Sleep disturbances;sleep health;sleep onset;sleep quality;stress management;Testing;Time;time use;tool;urinary;waist circumference

PROJECT_TITLE: Mechanisms underlying the relationship between sleep health and circadian timing with cardiometabolic risk in adolescents with type 1 diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Z (M2)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Contraception/Reproduction;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: In this study, we propose a new imaging tool to assess human uteroplacental vascularization in early pregnancy based on the pressure estimation using subharmonic aided pressure estimation (SHAPE) technique. We suggest using the mean pressure gradients between the uterine artery, placental bed (arteries in decidua and myometrium), and intervillous space as well as the standard deviation of SHAPE pressure estimates in the placental bed as functional indices of placental development. We hypothesize that these indices will correlate with the degree of uteroplacental vascularization, i.e., with gestational age in normal pregnancy.

PI_NAMEs: NAM, KIBO  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Area;Arteries;arteriole;Beds;Blood;Blood flow;Blood Pressure;Blood Vessels;Characteristics;Chronic;Circulation;contrast enhanced;Decidua;Development;Disease;Doppler Ultrasound;Drops;early pregnancy;Ensure;Estimation Techniques;Fetal Development;Fetal Growth Retardation;Fetal health;Frequencies;Gestational Age;health of the mother;hemodynamics;Human;hypoperfusion;Imaging Device;Imaging Techniques;improved;indexing;Individual;Intercellular Fluid;intracardiac pressure;Knowledge;Location;Malignant Neoplasms;Maternal-Fetal Exchange;Measures;Mechanics;Methods;Microbubbles;Modification;myometrium;non-invasive imaging;Nutrient;Pathologic;Perfusion;Physiological;Placenta;Placentation;Portal Pressure;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pressure;pressure sensor;Process;radial artery;Resistance;Signal Transduction;Specimen;Spiral Artery of the Endometrium;System;Techniques;Time;tool;Trees;Tube;Ultrasonography;ultrasound;Uteroplacental Circulation;Uterus;Variant;Vascular blood supply;Vascular remodeling;Vascularization;Villous;wasting

PROJECT_TITLE: Assessment of placenta vascularization development using contrast-enhanced ultrasound

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Genetics;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Injuries to the tendon-bone attachment, or enthesis, are frequent amongst the general population and existing treatments are limited with variable efficacy, leaving patients with high re-rupture rates, impacted quality of life, and increased likelihood of developing joint degenerative diseases. Unlike the mammalian enthesis which scars after injury, the zebrafish tendon-bone attachment can fully regenerate through mechanisms yet to be discovered. By employing cross-species comparative genetics and genomics approaches in zebrafish and mice after injury, this proposal will elucidate divergent signaling mechanisms driving successful enthesis regeneration versus fibrosis which may be leveraged to inspire new treatment strategies in the clinic.

PI_NAMEs: TSAI, STEPHANIE L (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Acceleration;Adult;Advisory Committees;Area;ATAC-seq;Automobile Driving;beta catenin;Biomechanics;bone;Cell Lineage;Cell Proliferation;cell type;Cells;Chemicals;Chromatin;Cicatrix;Clinic;Clinical;Communities;comparative;comparative genomics;constitutive expression;Cues;Data;Data Set;Degenerative polyarthritis;experimental study;Failure;Fascia;Fibroblasts;Fibrocartilages;Fibrosis;Fishes;Foundations;General Population;Genetic;genetic approach;Genetic Transcription;Genomic approach;Goals;Grant;healing;Impairment;improved;inhibitor;Injury;interstitial;Lead;Leadership;Mammalian Cell;Mammals;Maps;mechanical properties;Mentors;Mentorship;migration;Modeling;Molecular;Movement;multiphoton imaging;Mus;Natural regeneration;novel strategies;novel therapeutic intervention;Organ;Outcome;Pathway interactions;Patients;Phase;Population;Positioning Attribute;programs;Proliferating;Property;Quality of life;Recovery;recruit;regenerative;Regenerative Medicine;Research;response;RNA;Role;Rupture;scleraxis;Signal Transduction;single cell ATAC-seq;single cell genomics;Site;skill acquisition;skills;Source;Structure;System;Tendon force;Tendon Injuries;Tendon structure;Testing;Therapeutic;therapeutic target;Time;Tissues;Training;Transgenic Organisms;transmission process;Validation;WNT Signaling Pathway;Work;Writing;Zebrafish

PROJECT_TITLE: Cellular and molecular mechanisms driving regeneration and fibrosis of the tendon-bone attachment


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative G protein–coupled receptors (GPCRs) are common drug targets and include chemokine receptors, which help immune cells respond to infections and cancer. However, chemokine signaling is often dysregulated in many inflammatory skin and other diseases. My project will biochemically define a new GPCR chemokine signaling pathway in immune cells, which may provide new avenues to treat inflammatory diseases.

PI_NAMEs: SMITH, JEFFREY SCOTT (contact)

PROJECT_TERMS: Adrenergic Agents;Advisory Committees;Amino Acids;Autoimmune;Autoimmune Diseases;beta-arrestin;Binding;Biochemical;Biochemistry;Biological Assay;Biology;Biotin;career;cell type;Cells;Chemicals;chemokine;chemokine receptor;Clinical;clinically significant;cofactor;Complex;CRISPR/Cas technology;crosslink;Cryoelectron Microscopy;CXC chemokine receptor 3;CXCL10 gene;CXCL11 gene;CXCL9 gene;CXCR3 gene;cytokine;Data;design;Deuterium;dimer;Disease;Dopamine;Drug Targeting;Educational process of instructing;Event;Family;FDA approved;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Expression;Genetic Transcription;Goals;Grant;GTP-Binding Proteins;Guanosine Triphosphate;Heart Diseases;Heterotrimeric G Protein Subunit;Heterotrimeric GTP-Binding Proteins;Hydrogen;Immune;Immunoprecipitation;immunoregulation;improved;In Vitro;Infection;Inflammation;Inflammatory;interest;Knock-in;Label;Leadership;Ligands;Luciferases;lupus cutaneous;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Mental disorders;Mentors;Methods;Modification;Molecular;monomer;mutant;Mutate;Mutation;novel;novel therapeutics;Nucleotides;oral communication;Pathway interactions;Patient Care;Patients;Pharmaceutical Preparations;Pharmacology;Physicians;Post-Translational Protein Processing;preservation;professor;programs;Protein Family;protein purification;Proteins;Psoriasis;Publishing;receptor;Receptor Signaling;recruit;Research;Resolution;response;Role;Scientist;Signal Induction;Signal Pathway;Signal Transduction;Signaling Protein;Site;skills;Skin;Skin and Connective Tissue Diseases;skin disorder;structural biology;Structure;success;T cell response;T-Cell Activation;T-Lymphocyte;Therapeutic;therapeutic target;three dimensional structure;three-dimensional visualization;Tissues;Training;transcriptome sequencing;Translating;Work;Writing

PROJECT_TITLE: Biochemical Determinants of Chemokine Receptor Signaling


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PHR: PROJECT NARRATIVE Genes, which contain instructions for making all proteins in the body, are regulated by sequence-specific DNA interactions by transcription factors (TF). Current methods to detect TF-DNA interactions are biased for only the highest affinity interactions when medium-low affinity interactions are very important and more common. I have developed PADIT-seq, an improved technology to detect TF-DNA interactions across the entire spectrum of affinities. The overall goal of this proposal is to utilize and further develop PADIT-seq to uncover fundamental TF-DNA binding principles, which will significantly advance our mechanistic understanding of the principles governing gene regulation and genetic risk factors for complex diseases.

PI_NAMEs: KHETAN, SHUBHAM  (contact)

PROJECT_TERMS: Address;Affect;Affinity;Amino Acid Sequence;Applications Grants;Architecture;Award;Bacteria;Binding;Binding Proteins;Binding Sites;Biological Assay;C-terminal;career development;cell type;Cells;Code;Complement;Complex;Data;Development;Development Plans;Disease;DNA;DNA Binding;DNA Binding Domain;DNA Sequence;Doctor of Philosophy;Escherichia coli;experimental study;extracellular;Face;Faculty;Foundations;Future;Gene Expression;Gene Expression Regulation;gene network;Genes;genetic risk factor;Genetic Transcription;genetic variant;Genome;genome wide association study;Genomic approach;Genomics;Genotype;Goals;Human Development;human disease;improved;In Vitro;in vivo;Individual;innovation;insight;Instruction;Libraries;Link;Maps;Measures;Methods;Molecular;Mutation;new technology;novel;Nucleotides;Pancreatic Diseases;parallelization;paralogous gene;Phase;Phenotype;Plasmids;Play;Positioning Attribute;Postdoctoral Fellow;preference;Principal Investigator;Process;programs;Proteins;Publications;Regulatory Element;Reporter;Research;residence;response;RNA chemical synthesis;Role;Shapes;Signal Transduction;Single Nucleotide Polymorphism;Site;skills;Specificity;Technology;Testing;Time;Training;transcription factor;Transcriptional Regulation;transcriptome sequencing;Untranslated RNA;Variant;Work;Zinc Fingers

PROJECT_TITLE: Studying Protein Affinity to DNA by in vitro Transcription and Sequencing (PADIT-seq)

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE The WHO currently recommends annual mass azithromycin distribution in trachoma-endemic areas until the district-level prevalence of trachomatous inflammation-follicular (TF) drops below 5%. Since there is no true gold standard test to assess the prevalence of active disease, we will use a model which assumes a true, but latent or hidden state of infection. We anticipate that the results of this study will provide will show modestly improved precision of detecting the true state of trachomatis infection in a hypoendemic and hyperendemic communities.

PI_NAMEs: LIETMAN, THOMAS M (contact);PORCO, TRAVIS CHRISTIAN

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Affect;Antibiotics;Area;Azithromycin;Blindness;Child;Chlamydia trachomatis;Clinical;Clinical Trials;Communities;Country;Data;Disease;Dose;Drops;Ensure;Funding;Goals;Guidelines;Hot Spot;improved;Infection;Inflammation;Intervention;Long-Term Effects;markov model;Methods;Modeling;Modification;optimal treatments;Oral;parent grant;predictive modeling;Prevalence;programs;Protocols documentation;Public Health;Recommendation;Research;Signal Transduction;Surveillance Methods;Testing;theories;Trachoma;transmission process;Treatment Protocols;World Health Organization

PROJECT_TITLE: Forecasting Trachoma Control - Diversity Supplement


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BROOKINGS

ORG_NAME: SOUTH DAKOTA STATE UNIVERSITY

ORG_STATE: SD

PHR: Project Narrative Older adults – particularly older women – are at increased risk of prolonged inflammation and inflammatory- related diseases; one way through which older adults may be at higher risk for prolonged inflammation and inflammatory disease is through daily stress processes. The proposed research will examine how aspects of daily stressors (i.e., frequency, severity, immediate and prolonged affective reactions to daily stressors) are linked with inflammatory biomarkers in a racially and socioeconomically diverse sample of older adults, and how gender may differentially inform these associations. Study findings will determine the contexts in which intervention efforts may be particularly advantageous and may inform future studies using complex, repeated methodology.

PI_NAMEs: WITZEL, DAKOTA DANIELLE (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Address;Adult;Affect;Affective;Age;Aging;Anti-Inflammatory Agents;biological adaptation to stress;Biological Assay;Biological Markers;Black race;Blood;C-reactive protein;Complex;COVID-19 pandemic;cytokine;Data;design;diet and exercise;Disease;Ecological momentary assessment;Economic Burden;Equation;experience;Frequencies;Future;Gender;gender disparity;Goals;Health;health disparity;high risk;human old age (65+);IL8 gene;Immune response;improved;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;innovation;Interleukin-1 beta;Interleukin-10;Interleukin-4;Interleukin-6;Intervention;Joints;Knowledge;Link;Literature;Measurement;men;Methodology;middle age;Migration Inhibitory Factor;Mitogens;Modeling;modifiable risk;mortality;negative affect;novel;older adult;older men;Older Population;older women;Outcome;parent project;Pathway interactions;Persons;Pharmaceutical Preparations;Physiological;Positioning Attribute;Process;programs;psychosocial;Psychosocial Stress;Public Health;Race;racial diversity;Reaction;Reporting;Research;Research Design;Research Personnel;response;Risk;Risk Factors;Sampling;Severities;sex;Sex Differences;socioeconomics;Stress;stressor;systemic inflammatory response;Testing;theories;TNF gene;Woman;Work

PROJECT_TITLE: Stress and Affective Mechanisms that Relate to Inflammation in Diverse Older Men and Women