ORG_CITY: GAINESVILLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The proposed research aims to establish NR4A1 as a valid therapeutic target for melanoma. Using Proteolysis targeting chimera (PROTAC) technology, this project will develop first-of-its-kind NR4A1 degrader to potentially treat melanoma. Using in vivo models and cancer specimens, we will determine the mechanisms how NR4A1- targeting PROTACs work to promote an immune active environment and whether NR4A1 PROTAC is a useful tool for treating melanoma as a single agent or in combination with other frontline therapeutics.

PI_NAMEs: SMALLEY, KEIRAN ;ZHANG, WEIZHOU  (contact);ZHENG, GUANGRONG

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Agonist;analog;anti-PD1 antibodies;B-Lymphocytes;beta catenin;Binding;BRAF gene;cancer cell;cancer immunotherapy;cancer type;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;cell type;Cells;clinical translation;Clonal Expansion;Critical Pathways;CTLA4 gene;Data;Data Set;design;Development;diindolylmethane;Drug Kinetics;drug synthesis;effector T cell;Endometrial Carcinoma;Environment;Eragrostis;exhaust;exhaustion;Exhibits;Family member;fatty acid oxidation;Future;Goals;Growth;Immune;Immune checkpoint inhibitor;immunoregulation;Immunosuppression;In Vitro;in vivo;in vivo Model;Indoles;Infiltration;inhibitor;innovation;Killer Cells;Lead;Ligands;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;meetings;MEKs;Melanoma;Melanoma Cell;Metabolic;Modeling;Modification;Molecular;monocyte;Mus;Mutate;mutational status;Myeloid-derived suppressor cells;nanomolar;Natural Killer Cells;Nature;novel;Nuclear Orphan Receptor;Nuclear Receptors;Outcome;Pathway interactions;Patients;PD-1/PD-L1;pembrolizumab;Pharmaceutical Preparations;pharmacophore;programmed cell death protein 1;Property;Protac;Proteins;Protocols documentation;Publishing;rational design;recruit;Regulatory T-Lymphocyte;Rejuvenation;Renal Carcinoma;Reporting;Research;Resistance;Role;Safety;single-cell RNA sequencing;small molecule;small molecule inhibitor;Specimen;T-Lymphocyte;Technology;Therapeutic;therapeutic target;tool;treatment response;tripterine;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Proteolysis targeting chimera against nuclear receptor NR4A1 for melanoma therapy

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


ADMINISTERING_IC: HG

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: FARMINGTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: HUMAN GENOME ORGANIZATION INTERNATIONAL, INC.

ORG_STATE: CT

PHR: Narrative: This grant will support young investigators to attend the Human Genome Meeting (HGM) in 2024, 2025, and 2026. The HGM is an annual international scientific conference focused on the human genome, genomic medicine, and especially on education and bringing the benefits of new knowledge and understanding to all, focusing on those in low- and middle- income countries (LMICs).

PI_NAMEs: HAMOSH, ADA  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Africa;Asia;Award;Brazil;career;career development;Cities;Clinic;Coffee;Collaborations;Competence;Country;Databases;Development;disability;Disease;Education;Educational workshop;Ensure;equity, diversity, and inclusion;Ethics;Ethics Committees;Event;Faculty;Fellowship;Funding;Gender;Gene Structure;Genes;Genetic Counseling;genome analysis;Genome Mappings;Genomic medicine;genomic tools;Genomics;graduate student;Grant;Greece;Health;Housing;Human;Human Genetics;Human Genome;Human Genome Project;human genomics;improved;India;Infrastructure;interest;International;international scientific organization;Italy;Knowledge;Latin America;Laws;Legal;Link;Location;low and middle-income countries;meetings;member;Mentors;Mission;Names;Nomenclature;Persons;Population;Postdoctoral Fellow;posters;Prize;Research Personnel;Rome;Science;scientific organization;Scientist;Secure;Societies;South Africa;Structure;symposium;Time;tool;Training;Travel;Underrepresented Populations;UNESCO;Universities;Variant;web site;Work;World Health Organization

PROJECT_TITLE: Support for Young Investigators from LMICs to attend the Human Genome Meeting

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (J2)]


ADMINISTERING_IC: LM

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Data Science;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Narrative This project will develop new artificial intelligence methods and software for predicting health outcomes related to substance abuse in patients diagnosed with HIV infection. These new computational methods will be informed by knowledge derived from the primary literature about HIV, substance abuse, and their interaction. All software developed by the project will be released for free and as open-source so all researchers and clinicians can benefit from them.

PI_NAMEs: MOORE, JASON H. (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Acceleration;addiction;Adoption;Algorithms;analytical method;artificial intelligence method;automated algorithm;Biochemical Pathway;Biological Markers;Clinical;clinical biomarkers;Clinical Data;clinical data warehouse;clinical decision support;Clinical Research;Communities;comorbidity;Computer software;Computing Methodologies;Data;Data Analytics;data mining;data resource;Development;Diagnosis;Disease;Electronic Health Record;feature selection;Genes;Goals;graph database;Health;high risk population;HIV;HIV Infections;Hospitals;innovation;Knowledge;knowledgebase;large language model;Literature;Location;Los Angeles;Machine Learning;machine learning algorithm;machine learning method;machine learning model;machine learning pipeline;Measures;Medical center;Methods;Modeling;multimodal data;multimodal modeling;multimodality;natural language;novel;Ontology;open source;Outcome;Patients;Pharmaceutical Preparations;Precision Health;Research;Research Personnel;Resources;Running;Severities;software development;Substance abuse problem;Substance Use Disorder;Technology;Testing;translational approach;Translational Research;Trees;user-friendly

PROJECT_TITLE: Knowledge-guided automated machine learning methods for modeling the interaction of HIV with addictive drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 AS-C (01)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Summer Training as Research Scholars (STaRS) at Boston University is a summer Research Education Program for outstanding undergraduate and early medical school students from traditionally underrepresented groups in the biomedical sciences. The goal is to help ignite a passion for a career in biomedical research through immersion in authentic, faculty-mentored research experiences, supplemented by individualized career development planning (e.g., apply to and be accepted in graduate and medical programs). The program aims to promote a sense of belonging to the greater scientific research community among scholars, with the ultimate mission of retaining these scholars in research careers to diversify the biomedical workforce.

PI_NAMEs: DOMINGUEZ, MARIA ISABEL  (contact);WILSON, ANDREW A

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Address;Admission activity;aluminum sulfate;Biomedical Research;Boston;career;Career Choice;career development;career networking;college;Communication;Communities;community building;Critical Thinking;Degree program;design;Development Plans;Disease;Doctor of Philosophy;Education;education research;Educational workshop;Effectiveness;experience;Faculty;faculty mentor;Feedback;Fortification;Fostering;Funding;Future;Goals;Graduate Degree;Graduate Education;graduate school;Grant;Heart Diseases;Hematological Disease;higher education;Immersion;improved;innovation;journal article;Learning;Lung Diseases;matriculation;Medical;medical schools;Medical Students;Mentors;Methods;Mission;Monitor;National Heart, Lung, and Blood Institute;Outcome;Outcome Assessment;Pathway interactions;Physicians;programs;Readiness;recruit;Reporting;Research;research and development;Research Personnel;Research Project Grants;Resources;role model;satisfaction;Scholars Program;Science;Scientist;Self Assessment;skills;Sleep Disorders;Social Network;Students;success;Suggestion;summer research;Time;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: STaRS at BU - Summer Training as Research Scholars at Boston University

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-A (J1)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Microbiome;Rare Diseases;Vector-Borne Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Completing these studies will 1) provide mechanistic insight into how gut bacteria engage with the local gut and gut-distal immune system to impact Plasmodium-induced humoral immunity, 2) provide translational relevance to African children, and 3) identify how antibiotic treatment alters interactions between the gut bacteria-host immunity-Plasmodium triad to prevent severe malaria. These studies are poised to support the use of antibiotics to prevent severe malaria-related mortality in African children. Of note, antibiotic treatment has been tested for malnutrition in African children, providing a conceptual framework to use antibiotics to prevent severe malaria.

PI_NAMEs: SCHMIDT, NATHAN  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Affect;African;Antibiotic Therapy;Antibiotics;Bacteria;Bacteriology;Bacteroides;Cellular Immunology;Cerebral Malaria;Child;Colon;Data;Distal;experimental study;Feces;gut bacteria;gut microbiome;gut microbiota;Human;Humoral Immunities;Immune;Immune response;Immune system;Immunity;In Vitro;in vivo;Infection;insight;Intervention;Intestines;Malaria;malarial anemia;Malawi;Mali;Malnutrition;Mediating;member;Metronidazole;microbiome therapeutics;microbiota;Molecular;mortality;Mus;novel;Oral;Outcome;Parasite Control;Parasitemia;Parasites;Pathway interactions;Plasmodium;Plasmodium falciparum;Predisposition;prevent;Production;Propionates;Publications;Publishing;Regulatory T-Lymphocyte;Resistance;response;Role;secondary lymphoid organ;Series;Severities;Severity of illness;Shapes;Spleen;Structure of germinal center of lymph node;Testing;therapeutic target;Tissues;translational potential;Uganda;Vancomycin;Vendor;Volatile Fatty Acids

PROJECT_TITLE: Role of the Gut Microbiota in Shaping Severity of Malaria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (02)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Congenital Structural Anomalies;Heart Disease;Pediatric

ORG_CITY: STONY BROOK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Narrative This study aims to develop a new generation of Zn-based drug-eluting bioresorbable cardiovascular stents that possess sufficient mechanical strength, stability, and ideal biocompatibility without toxicity. The use of these novel stents would improve patients’ quality of life by providing a better recovery experience and eliminating the need for a second surgery and long-term complications due to their full biodegradability, particularly for young children.

PI_NAMEs: CHENG, KE ;ZHU, DONGHUI  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: abdominal aorta;absorption;Address;Adopted;Adult;Alloys;Anatomy;Anesthesia procedures;Angiography;Animal Model;Animals;Anti-Bacterial Agents;Aorta;aorta constriction;Aortic coarctation;Applications Grants;Area;Arteries;Biodegradation;biomaterial compatibility;Blood;blood pump;Blood Vessels;Body Fluids;Cardiovascular system;Cell Differentiation process;Cell Survival;Chest Pain;Child;Childhood;Congenital Heart Defects;Coronary Arteriosclerosis;Cost Savings;Descending aorta;design;Development;Diameter;drug release profile;Echocardiography;Effectiveness;Endothelium;Ensure;Excision;Exhibits;experience;Family suidae;Foundations;Funding;Future;Generations;Goals;Gram-Negative Bacteria;Growth and Development function;Headache;Health;Heart;heart defect;Heart Diseases;hemocompatibility;Histologic;Human;Hyperplasia;Hypertension;Immersion;Immune response;Implant;improved;In Vitro;in vivo evaluation;Inflammation;innovation;Intervention;Investigation;Investigational Drugs;Leg Cramp;Legal patent;Lithium;Magnesium;Manganese;mechanical properties;Mechanics;metallicity;Modeling;Molecular Weight;Monitor;novel;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;pediatric patients;Performance;Pharmaceutical Preparations;poly-L-lactic acid;polycarbonate;porcine model;Procedures;Process;Property;prototype;Quality of life;Radial;Rattus;Recovery;Research;Research Personnel;response;restenosis;Rodent;Role;Safety;Sirolimus;stem cell growth;Stenosis;Stents;success;Symptoms;Testing;Thick;Time;Tissues;Titanium;Toxic effect;Treatment Efficacy;Ultrasonography;United States National Institutes of Health;Work;Workload;Zinc

PROJECT_TITLE: Bioresorbable zinc-based drug-eluting stents for pediatric cardiovascular applications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Relevance to Public Health Cardiovascular disease (CVD) is leading cause of death in the United States and represents a significant burden to the national health system. We have uncovered a novel layer of posttranscriptional regulation for LDLR, the determinant of plasma cholesterol and the key driver of CVD, which may result in improved therapeutic interventions.

PI_NAMEs: TARLING, ELIZABETH JOANNA (contact);VALLIM, THOMAS A

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: 3' Untranslated Regions;Affect;apolipoprotein E-3;atheroprotective;Atherosclerosis;Bile Acid Biosynthesis Pathway;Bile Acids;Binding;Binding Proteins;Binding Sites;Biological Assay;Cardiovascular Diseases;cardiovascular disorder risk;Catabolism;Cause of Death;CETP gene;Cholesterol;cholesterol control;Cholesterol Homeostasis;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;crosslink;crosslinking and immunoprecipitation sequencing;CYP7A1 gene;Data;design;Enzymes;Family;Feedback;Female;functional genomics;gain of function;Genes;Genetic Transcription;Genomic Segment;Health system;Hepatic;High-Throughput Nucleotide Sequencing;Human;Immunoprecipitation;improved;in vivo;Knockout Mice;LDL Cholesterol Lipoproteins;Lipoproteins;Liver;Low-Density Lipoproteins;Luciferases;male;Mediating;Messenger RNA;Metabolic Pathway;Modeling;Molecular;mouse model;mRNA Decay;mRNA Stability;Mus;novel;particle;Pathway interactions;Plasma;Post-Transcriptional Regulation;posttranscriptional;Proteins;Public Health;Publishing;Regulation;Reporter;Reporting;Response Elements;Risk Factors;RNA-Binding Proteins;System;Testing;Therapeutic Intervention;Tracer;Transgenes;United States;Untranslated Regions;uptake;Variant;Work

PROJECT_TITLE: Post-transcriptional regulation of LDLR

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Social Determinants of Health;Substance Misuse

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE The Research in Addiction Medicine Scholars (RAMS) Program is significant because it engages trainees who are future clinical researchers and leaders in the expanding subspecialties of Addiction Medicine and Addiction Psychiatry. RAM Scholars’ research will seek to improve patient care; reduce the medical, social, and financial burden of individuals with substance use disorders; and promote equitable treatment and research.

PI_NAMEs: O'CONNOR, PATRICK ;SAMET, JEFFREY H. (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Academic Medical Centers;Acceleration;Active Learning;addiction;Address;Advisory Committees;Advocacy;aluminum sulfate;American;British Columbia;Canada;career;career development;Caring;Clinical;Clinical Investigator;Clinical Research;college;Communities;Dedications;Development;Drug Addiction;Educational Curriculum;Equity;equity, diversity, and inclusion;ethnic diversity;Faculty;falls;Feedback;Fellowship Program;Financial Hardship;Fostering;Future;Goals;Harm Reduction;improved;Individual;Infrastructure;innovation;Institution;Intervention;knowledge base;Leadership;leadership development;marginalization;Medical;Medicine;meetings;Mentors;Mentorship;Mission;multidisciplinary;National Institute of Drug Abuse;next generation;Outcome;Patient Care;Persons;Physicians;prevent;Prevention;programs;Psychiatry;Race;racial diversity;Racial Equity;recruit;Research;Research Personnel;Research Project Grants;Research Training;Residencies;Risk;Scholars Program;Scientific Advances and Accomplishments;Scientist;Site Visit;skills;social;Social Justice;Strategic Planning;Structure;substance use;Substance Use Disorder;substance use treatment;success;symposium;System;Telephone;Training;United States;webinar

PROJECT_TITLE: Advancing Clinical Research Training within Addiction Residency Programs

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Small cell lung cancer (SCLC) is a recalcitrant subtype of lung cancer for which there are limited treatment options. This study will employ novel mouse and patient-derived models of SCLC as well as state-of-the-art technologies in single cell genomics and lineage-tracing to determine the function of NEUROD1 in SCLC. This work is relevant to public health and the NIH mission because it is aimed to improve the quality of life and survival of lung cancer patients by increasing our understanding of SCLC molecular subtypes and their associated therapeutic vulnerabilities.

PI_NAMEs: OLIVER, TRUDY GALE (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Address;Alleles;Apoptosis;ASCL1 gene;BETA2 protein;Biological Assay;Cancer Patient;cancer subtypes;cancer therapy;cancer type;Cells;Cessation of life;Characteristics;chemotherapy;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Combination Drug Therapy;Complement;Consensus;Coupled;CRISPR screen;Data;Dependence;Development;Disease;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Exhibits;experimental study;Genes;Genetic;Genetic Screening;Genetic Transcription;Genetically Engineered Mouse;Goals;Histologic;Histopathology;Human;Human Cell Line;Immunocompetent;Immunotherapy;improved;in vivo;individualized medicine;innovation;Knock-out;Lung Adenocarcinoma;lung cancer cell;Lung Neoplasms;Lung Neuroendocrine Neoplasm;Malignant neoplasm of lung;Mediating;Medulloblastoma;MFNG gene;microCT;Mission;Modeling;Molecular;molecular subtypes;mortality;mouse model;Mus;mutant;MYC-Family Oncogene;MYCL1 gene;MYCN gene;neoplastic cell;Neuroendocrine Prostate Cancer;Neurons;Neurosecretory Systems;new therapeutic target;notch protein;novel;Oncogenes;Oncogenic;Organoids;overexpression;Pathway interactions;patient derived xenograft model;patient stratification;Patients;pharmacologic;Population;Proliferating;Public Health;Quality of life;RB1 gene;Regulation;Repression;Research;Resistance development;Resolution;response;Role;Signal Transduction;single cell genomics;single-cell RNA sequencing;small cell lung carcinoma;standard of care;Survival Rate;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;Time;TP53 gene;transcription factor;treatment strategy;tumor;tumor initiation;tumor progression;Tumor Suppressor Proteins;United States National Institutes of Health;Work;X-Ray Computed Tomography

PROJECT_TITLE: NEUROD1 function in SCLC fate and plasticity

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Obesity;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative A diverse scientific workforce can produce more innovative outcomes; however, the presence of underrepresented individuals in the workforce is low. A mentored research experience as an undergraduate can increase persistence in scientific fields. This proposal will support mentored research experiences relevant to the scope of the National Heart, Lung, and Blood Institute.

PI_NAMEs: IKRAMUDDIN, SAYEED  (contact);JACOBS, DAVID R

PROJECT_TERMS: Admission activity;African American population;African American student;Age;American;Artificial Intelligence;Atherosclerosis;Back;bariatric surgery;Basic Life Support;Bioinformatics;Biomedical Research;cardiovascular collapse;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;cardiovascular transplantation;career;Caring;Cause of Death;Cellular biology;Clinical;Clinical Trials;cohort;college;Community Outreach;Complex;Critical Thinking;Data;Data Analyses;Data Reporting;Death Rate;Dedications;Development;Diet;disability;Disease;Doctor's Degree;Education;education research;Educational Curriculum;Educational Status;Endothelial Cells;Enrollment;Evaluation;Exercise;experience;Exposure to;Faculty;follow-up;Foundational Skills;Funding;Goals;graduate school;Growth;Health;Health Services Research;Health system;Healthcare;Heart;Hematology;Hemorrhagic Shock;Individual;Inflammation;Informatics;innovation;Insulin Resistance;interest;Journals;Knowledge;Leadership;Learning;life span;Lung;Maps;Master of Science;matriculation;medical schools;Medicine;meetings;Mentors;Mentorship;Metabolic Diseases;microbiome;Minnesota;Minority Groups;Mission;Monitor;Myocardial;National Heart, Lung, and Blood Institute;Natural Language Processing;neuroregulation;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Obesity;Operating Rooms;Operative Surgical Procedures;Oral;Outcome;Physicians;Population;posters;pre-clinical research;Preparation;programs;regenerative approach;Reporting;Research;Research Project Grants;Resources;response;Risk Factors;Science;Scientist;service learning;simulation;skill acquisition;skills;Smoking;social media;stem;STEM field;Stroke;Students;success;summer research;surgical research;surgical service;Surveys;System;Testing;Time;Training;Training Support;Translational Research;Trauma;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;volunteer;Vulnerable Populations;Work;Writing

PROJECT_TITLE: M-STEPP


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Frontotemporal dementia (FTD) is a neurodegenerative disease that is one of the most common dementias for people under 60, and circadian disruptions are prevalent among patients with neurodegenerative diseases, including FTD. Since humans and flies share conserved molecular mechanisms underlying neurodegenerative and circadian processes, this work will offer valuable insights into the mechanisms connecting circadian dysfunction and FTD and may ultimately lead to novel biomarkers and treatment options for FTD.

PI_NAMEs: KOH, KYUNGHEE  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Acceleration;Adult;ALS patients;Alzheimer's disease related dementia;antimicrobial;Appearance;Arginine;behavioral phenotyping;Biological Process;C9ORF72;Cactaceae;Candidate Disease Gene;candidate identification;cellular pathology;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clock protein;Collection;Data;Defect;Dementia;Dipeptides;Disease;disease model;Disease Progression;DNA Sequence Alteration;Dose;Double-Stranded RNA;Down-Regulation;Drosophila genome;Drosophila genus;Eye;fly;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;gain of function;Genes;Genetic;Genetic Screening;Genome;genome wide screen;Heterozygote;Human;Huntington Disease;Individual;insight;knock-down;Link;Mediating;Modeling;Modification;Molecular;Mutation;Natural Immunity;Nerve Degeneration;Neurodegenerative Disorders;Neurons;NF-kappa B;novel;novel marker;Nucleotides;null mutation;Orthologous Gene;overexpression;Pathogenesis;Pathology;Pathway interactions;Patients;Periodicity;Persons;Phenotype;Proline;Proteins;receptor;Receptor Signaling;Research;RNA;RNA Interference;Role;Signal Pathway;Signal Transduction;Sleep Disorders;Sleep disturbances;Sleep Wake Cycle;System;Testing;Toll-Like Receptor Pathway;Toll-like receptors;Toxic effect;transcription factor;Work

PROJECT_TITLE: Molecular pathways linking frontotemporal dementia and circadian dysfunction

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE Cardiovascular disease remains the number one cause of death in the United States. Despite lipid-lowering therapy, many patients remain at high risk of a cardiovascular event, and inflammation has been identified as a major residual risk factor. Our proposal aims to identify metabolic pathways contributing to inflammation resolution in atherosclerotic plaque and why they fail with disease progression, with the ultimate goal of discovering novel therapeutic strategies for treatment of cardiovascular disease.

PI_NAMEs: MOORE, KATHRYN J (contact)

PROGRAM_OFFICER_NAME: PLAYFORD, MARTIN P

PROJECT_TERMS: 3-Dimensional;Acceleration;Aconitic Acid;Address;Anti-Inflammatory Agents;Antiinflammatory Effect;antimicrobial;Antioxidants;Arterial Fatty Streak;Arterial Intimas;Arteries;ATAC-seq;atherogenesis;Atherosclerosis;Automobile Driving;Bacterial Infections;Blood Vessels;Bone Marrow;Carboxy-Lyases;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Carotid Artery Plaques;Cause of Death;Cell Physiology;Cells;Cellular Stress;chemokine;ChIP-seq;Cholesterol;Chronic;Citric Acid Cycle;Clinical;Coupled;cytokine;Cytometry;Data;Deposition;design;Disease Progression;Enzymes;Epigenetic Process;epigenetic silencing;epigenomics;Event;extracellular;feeding;Foundations;Genes;Glycolysis;Glycolysis Inhibition;Goals;high dimensionality;high risk;Human;human RNA sequencing;hypercholesterolemia;Image;Immune;Immune response;Immunity;immunoregulation;Impairment;In Vitro;in vivo;in vivo Model;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;innovation;Interleukin-1 beta;Interleukin-6;Investigation;LDL Cholesterol Lipoproteins;Learning;Lipids;Low-Density Lipoproteins;Macrophage;Mass Spectrum Analysis;Metabolic;Metabolic Control;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;microbial;Modification;monocyte;mouse model;multiplexed imaging;Mus;Myeloid Cells;Myeloid Progenitor Cells;Myocardial Infarction;neutrophil;novel;novel therapeutic intervention;Oxidative Stress;oxidized low density lipoprotein;Oxygen;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Permeability;Plasma;Pre-Clinical Model;prevent;Process;Production;Reactive Oxygen Species;recruit;Regulation;Residual state;Resolution;response;Risk;Risk Factors;Role;sensor;Signal Transduction;single cell analysis;single-cell RNA sequencing;stem;Stenosis;Sterility;Stroke;Succinate Dehydrogenase;systemic inflammatory response;T-Lymphocyte;Testing;Therapeutic;Therapeutic Uses;Time;Tissues;Training;transcription factor;treatment strategy;United States;western diet;Work

PROJECT_TITLE: The role of immune-responsive gene 1 and itaconate in atherosclerotic disease


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project narrative Adolescent binge drinking can lead to long-term deficits in behavioral flexibility and functional connectivity across brain regions. This project will study the role of perineuronal nets, which are extracellular matrix structures, in alcohol’s long-lasting effects.

PI_NAMEs: ROBINSON, DONITA L (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: 17 year old;ADAMTS;Address;Adolescence;Adolescent;adolescent alcohol exposure;adolescent binge drinking;aggrecan;alcohol consequences;Alcohol consumption;alcohol exposure;alcohol measurement;alcohol use disorder;Alcohols;Animal Model;Attention;Behavior;Behavior assessment;Behavioral;binge drinking;Brain;Brain region;brevican;Cognitive;cognitive performance;comparison control;conditioning;Consumption;Data;design;Development;drinking;Encapsulated;Epigenetic Process;Ethanol;Exhibits;experimental study;Extracellular Matrix;Female;flexibility;Foundations;Functional impairment;Functional Magnetic Resonance Imaging;functional restoration;Human;Impairment;improved;Infusion procedures;interest;Interneurons;Knowledge;Link;Magnetic Resonance Imaging;male;Measures;Mental disorders;Methods;Molecular;Nervous System Disorder;neurochemistry;neurotransmission;novel;Outcome;Parvalbumins;Pattern;Peptide Hydrolases;Performance;Physiological;Publishing;Rattus;Reporting;Rest;Reversal Learning;Risk Taking;Role;sex;Stimulus;Structure;Testing;Thalamic structure

PROJECT_TITLE: Role of perineuronal nets in adolescent alcohol-induced deficits

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative The Boston Bacterial Meeting (BBM) brings together bacteriologists at varying career stages and from distinct subfields of bacteriology and provides an opportunity for them to meet, hear the latest research, discuss new ideas and methods, and initiate collaborations. BBM is especially important in that it specifically promotes the careers of young scientists by allowing them to present their own research, be introduced to work done across disparate fields of bacteriology, and by providing an opportunity for them to network in the local scientific community. By including basic scientists, healthcare professionals, and industry researchers, BBM helps disseminate recent work, and foster creative collaborations that produce new ideas for infectious disease treatment and prevention.

PI_NAMEs: BERNHARDT, THOMAS G (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TITLE: 2024 Boston Bacterial Meeting (BBM)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: EAST LANSING

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE This research will explore the link between early life adversity, mast cells, and lifelong chronic inflammatory disease, through a mechanism involving modulation of cholesterol metabolism and heightened pro- inflammatory granule mediator production. These findings will contribute to the current understanding of ELA associated inflammatory and metabolic diseases and will be utilized for development of novel intervention strategies. Through this study, the applicant will broaden their technical and analytical skills, which will be critically useful during their career as they become an impactful, interdisciplinary, and translational scientist.

PI_NAMEs: LEMON, JANELLE  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: acute stress;Adult;adult stem cell;Atherosclerosis;Automobile Driving;behavioral response;Binding;biological sex;Bone Marrow;career;Cells;Cellular Stress;Characteristics;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;Cholesterol Synthesis Inhibition;Chronic;chronic inflammatory disease;Chronic stress;cytokine;Cytoplasmic Granules;Data;Development;Diabetes Mellitus;differentiation in vitro;Disease;Disease susceptibility;early life adversity;Effector Cell;Exhibits;experimental study;Face;Female;fluvastatin;Gene Expression;Generations;Genes;Genetic Transcription;Hematopoiesis;Hematopoietic stem cells;Histamine;Hyperactivity;Hypersensitivity;IgE;Immune;Immune response;Immunity;Immunological Models;In Vitro;in vivo Model;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Intervention;Leukocytes;Life;Link;Literature;Long-Term Effects;Longitudinal Studies;Mass Spectrum Analysis;mast cell;maternal separation;Mediating;Mediator;Metabolic;Metabolic Diseases;metabolome;Modeling;Molecular;mouse model;Mus;Neonatal;neonatal mice;novel;Obesity;pathogen;Pathway interactions;Peptide Hydrolases;pharmacologic;Phenotype;Play;porcine model;Predisposition;Production;Program Development;programs;Research;Risk;Risk Factors;RNA Sequences;Role;Same-sex;Secretory Vesicles;sex;Sexual Development;Shapes;Signal Pathway;Signal Transduction;skills;stem cells;Sterols;Symptoms;systemic inflammatory response;Testing;tissue/cell culture;Tissues;transcriptome sequencing;translational scientist;Up-Regulation;Weaning;Western Blotting;women versus men

PROJECT_TITLE: Early life adversity and biological sex developmentally heighten the mast cell proinflammatory phenotype by modulating its cholesterol metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Epilepsy;Gene Therapy;Genetics;Human Genome;Immunotherapy;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: RELEVANCE TO PUBLIC HEALTH The prognosis for GBM patients remains dismal and there is an urgent unmet need for novel therapies. The first oncolytic virus to be approved by the FDA is an oncolytic HSV whose use is prescribed for melanoma patients is HSV-1 derived. Japan has also recently conditionally approved use of an oncolytic HSV for GBM patients. Thus there is a lot of interest in developing this treatment modality. To increase the utility of this novel approach for brain tumor patients we propose to create and optimize a oncolytic HSV for therapy.

PI_NAMEs: KAUR, BALVEEN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acids;Adult;Affect;Aftercare;antiporter;Brain;Brain Neoplasms;CD44 gene;CD8-Positive T-Lymphocytes;Cell Death;cell motility;Cell Surface Receptors;Cells;Characteristics;chemotherapy;ChIP-seq;Collaborations;combat;comparison control;Cystine;Data;Diagnosis;Disease;DNA Damage;DNA Repair;Epilepsy;experience;extracellular;Extracellular Domain;Extracellular Matrix;FDA approved;Frequencies;Genetic Transcription;Glioblastoma;Glioma;Glutamates;Goals;Growth;Herpesvirus 1;Human;Hyaluronic Acid;Immunity;Immunocompetent;Immunofluorescence Immunologic;improved;In Vitro;in vivo;interest;Japan;Long-Term Survivors;Maximum Tolerated Dose;Measures;Melanoma;Melanoma patient;Metabolism;Modality;mouse model;Mus;neoplastic cell;next generation;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncolytic;oncolytic virotherapy;Oncolytic viruses;Patients;Phosphorylation;PI3K/AKT;Production;Prognosis;Proto-Oncogene Proteins c-akt;Public Health;Publishing;Quality of life;Radiation;Radiation therapy;receptor;Recurrence;Resistance;Resistance development;Safety;Seizures;Signal Induction;Signal Transduction;Simplexvirus;single-cell RNA sequencing;standard of care;stem cells;stemness;Symptoms;T-Cell Activation;T-Cell Depletion;temozolomide;Therapeutic;Therapeutic Index;transcriptome sequencing;Treatment Efficacy;tumor;tumor heterogeneity;Tumor Immunity;tumor microenvironment;tumorigenic;Universities;Viral;Virotherapy;Virus;Work

PROJECT_TITLE: Next generation oncolytic virotherapy targeting AKT and ERK signaling in glioma

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Nutrition;Osteoporosis

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Vitamin D is a critical factor that affects the intestine by enhancing calcium absorption, protecting the intestinal barrier, reducing gut inflammation, and reducing colon cancer risk. The intestinal effects of vitamin D change across the lifespan, leading to intestinal vitamin D resistance in older adults. We will use state of the art genomic technology to understand how intestinal resistance develops and test a strategy to promote intestinal calcium absorption to prevent adult- and age-related bone loss.

PI_NAMEs: CHRISTAKOS, SYLVIA S (contact);FLEET, JAMES C.;VERZI, MICHAEL P.

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Address;Adult;Affect;Age;age related;age related changes;Age-Related Bone Loss;Aging;ATAC-seq;Binding;Biology;bone;bone loss;Bone Resorption;Calcium;calcium absorption;calcium intake;calcium metabolism;carcinogenesis;CDX2 gene;ChIP-seq;Chromatin;Collaborations;Colon;colon cancer risk;Colon Carcinoma;Colonic inflammation;CRISPR-mediated transcriptional activation;Data;design;Dihydroxycholecalciferols;Disease;Elderly;Enhancers;Epigenetic Process;Event;Foundations;GATA4 gene;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genomic approach;Genomics;Glucuronides;Goals;Grant;Growth;gut inflammation;Health Benefit;high risk;HNF4A gene;Hormonal;Human;Hypercalcemia;improved;Inflammation;Inflammatory;intestinal barrier;intestinal crypt;intestinal villi;Intestines;Knowledge;life span;Malabsorption Syndromes;Malignant Neoplasms;Mediating;Modeling;Molecular Biology;Mus;nuclear receptor coactivator 1;Nucleic Acid Regulatory Sequences;Nutrient;nutritional genomics;old mice;older adult;Older Population;Organoids;Osteoporosis;Physiologic calcification;Porosity;Positioning Attribute;prevent;Productivity;promoter;Proteins;receptor binding;Regulation;Research;Resistance;Resistance development;Rodent;Role;Serum;Small Intestines;substantia spongiosa;Syndrome;Technology;Testing;Transcription Coactivator;transcription factor;transcriptome sequencing;VDR interacting protein complex DRIP;Villus;Vitamin D;Vitamin D3 Receptor;Work

PROJECT_TITLE: Nutrigenomics of Intestinal Vitamin D Action

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Cannabinoid Research;Chronic Pain;Endocannabinoid System Research;Neurosciences;Pain Research;Therapeutic Cannabinoid Research

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Fatty acid binding protein 5 is a lipid chaperone implicated in pain modulation and is a promising target for the development of next-generation analgesics. This study seeks to identify a novel function for this protein in lipid- mediated pain hypersensitivity. The outcome of this study will greatly improve our understanding of fatty acid binding protein 5 function and may lead to novel therapeutic strategies to treat pain.

PI_NAMEs: KACZOCHA, MARTIN  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Absence of pain sensation;addiction;addiction liability;Adult;Affect;Afferent Neurons;Affinity;Anabolism;Analgesics;anandamide;ANK1 gene;Antibodies;antinociception;arthritic pain;Behavior;Behavioral;Binding;Binding Sites;Biological;Biological Process;Biological Sciences;Calcium;cannabinoid receptor;Cannabinoids;Carrier Proteins;CASP1 gene;Cell secretion;Cells;Central Nervous System;chemokine;chronic pain;chronic pain management;cytokine;Development;drug development;Eicosanoids;Electrophysiology (science);Endocannabinoids;Enzymes;extracellular;Family;fatty acid-binding proteins;Foundations;Future;Hyperalgesia;Hypersensitivity;Image;Immune;improved;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory modulation;inflammatory pain;inhibitor;Knockout Mice;Knowledge;Lead;Leukotriene B4;Leukotrienes;Ligand Binding;Link;lipid transport;Lipids;LTB4R gene;Mediating;Mediator;Molecular Chaperones;Mus;mutant;Myelogenous;Myeloid Cells;neurochemistry;Neurons;next generation;Nociception;Nociceptors;non-opioid analgesic;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutic intervention;Opiate Addiction;Opioid;opioid abuse;opioid use;Outcome;Outcome Study;Pain;Pain management;pain model;pain relief;painful neuropathy;palmidrol;Pathway interactions;Peripheral Nervous System;Population;Positioning Attribute;PPAR alpha;pre-clinical;protein function;Proteins;Quality of life;receptor;Receptor Activation;Regulation;research clinical testing;Schedule;Signal Pathway;Signal Transduction;Site;Spinal Ganglia;Testing;Therapeutic;Tissues;TLR4 gene;translational potential;TRP channel;TRPA channel;TRPV1 gene;Vanilloid;Work

PROJECT_TITLE: FABP5: Novel functions in pain modulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-N (03)]


NIH_SPENDING_CATS: Diabetes;Genetics

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative In this proposal we will explore the mechanisms by which Nrf2 preserves -cell mass and acts as a common node for the eicosanoid and incretin signaling pathways, and we will test the exciting therapeutic potential of activating combinations of these pathways to treat diabetes. These studies are directly relevant to the many millions of patients with diabetes worldwide who will benefit from the knowledge generated with these studies that could lead to the development of novel therapeutic strategies to treat this disease.

PI_NAMEs: GANNON, MAUREEN A;GARCIA-OCANA, ADOLFO ;SCOTT, DONALD K. (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Affect;Age;Aging;Agonist;antagonist;antioxidant enzyme;Antioxidants;ATAC-seq;Beta Cell;Biological Models;Cell Proliferation;Cells;ChIP-seq;Chromatin;Cues;Cyclic AMP;cytokine;Cytoprotection;Data;db/db mouse;Development;Diabetes Mellitus;Diabetic mouse;Diet;Dinoprostone;Disease;Eicosanoids;experience;G-Protein-Coupled Receptors;gain of function;Gene Targeting;Genes;Genetic Transcription;GLP-I receptor;Glucose;Glucose Intolerance;glucose tolerance;Human;Immunodeficient Mouse;improved;in vivo;innovation;Insulin;islet;Knowledge;Lead;Link;loss of function;Mediating;Metabolic stress;Modeling;Molecular;mouse model;novel therapeutic intervention;Oxidative Stress;Pathway interactions;Patients;Phenotype;Play;Positioning Attribute;preservation;prevent;Proliferating;Protective Agents;Publishing;receptor;Receptor Activation;Research Personnel;Role;Signal Pathway;Signal Transduction;Testing;Therapeutic;therapeutic evaluation;therapy development;Toxic effect;transcriptome;transcriptome sequencing;Transplantation;Treatment Efficacy;WFDC2 gene;Work

PROJECT_TITLE: Nrf2 and the expansion and preservation of beta cell mass

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Invasive fungal infections in immune compromised patients such as those undergoing chemotherapy or high dose corticosteroid treatments are a major impediment to human health. Infections by moulds are particularly problematic and often resistant to contemporary antifungal therapy. This proposal will further develop a novel small molecule with potent antifungal activity against human pathogenic moulds.

PI_NAMEs: CRAMER, ROBERT ANDREW (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Allergic Bronchopulmonary Aspergillosis;analog;anti-fungal agents;Antifungal Therapy;aqueous;Aspergillosis;Aspergillus;Aspergillus fumigatus;Automobile Driving;Azole resistance;Azoles;Biochemical;Biochemical Pathway;Biological Assay;Biology;Cessation of life;Chemicals;Chemosensitization;chemotherapy;Clinical;Collaborations;combat;Complex;Data;design;Development;Dose;Drug Kinetics;Drug resistance;Drug Utilization;efficacy testing;Exhibits;Family;Fluconazole;Fluconazole resistance;Fungal Drug Resistance;Future;Generations;Genetic;Goals;Health;Human;human pathogen;Immune;improved;In Vitro;in vitro Assay;in vivo;indexing;Infection;innovation;Knowledge;Lead;lead optimization;Liver Microsomes;meter;model design;Molds;Molecular Target;mouse model;Mucor;Multi-Drug Resistance;Mus;Mycoses;new therapeutic target;novel;Outcome;Oxygen;pathogenic fungus;Pathogenicity;Patients;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;piperidine;pre-clinical;Process;Property;Research Project Grants;Resistance;resistant Aspergillus;Rhizopus;Role;Safety;Series;Site;small molecule;Solubility;Structure-Activity Relationship;Study models;synergism;Technology;Therapeutic Index;Treatment Failure;Triazoles;Voriconazole

PROJECT_TITLE: Optimization and chemical biology of novel antifungals to combat azole resistant mould infections

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Any animal nervous system is composed of two types of cells, neuron and glia, each of critical importance of the function of the brain. The aim of this grant proposal is to explore unitary principles of nervous system development. Using a simple invertebrate model system as a test case, we test here the hypothesis that an evolutionarily conserved class of transcription factors, called homeobox genes, are regulators of glial cell fate specification throughout the entire nervous system of an animal.

PI_NAMEs: HOBERT, OLIVER  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Alleles;Animals;Applications Grants;Architecture;aspirate;Atlases;Biological Models;Brain;C. elegans genome;Caenorhabditis elegans;cell fate specification;cell type;Cells;Code;Collection;comparative;Complement;CRISPR/Cas technology;Fingers;Future;gain of function;gene function;Genes;Genetic;Genetic Markers;Genome engineering;Glial Differentiation;Hermaphroditism;HMGB Family Gene;Homeobox;Homeobox Genes;Homeodomain Proteins;Individual;insight;Invertebrates;Life;Lobular Neoplasia;loss of function;Maintenance;Maps;mutant;Nervous System;nervous system development;Neuroglia;Neurons;Phylogenetic Analysis;protein complex;protein expression;Proteins;Reporter;Resolution;Specific qualifier value;System;Testing;tool;Transcript;transcription factor;Work

PROJECT_TITLE: Regulatory Architecture of Glia Cell Type Diversity in C. Elegans

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: Project Narrative The proposed studies aim to reveal the structures and functions of various forms of N-methyl-D-aspartate receptor (NMDAR) ion channels, which play a significant role in brain function and development. These studies are relevant to public health because dysfunctional NMDARs are implicated in neurological disorders such as Alzheimer’s disease, depression, and stroke. Understanding what types of NMDARs are present in the brain and how they recognize compounds and regulate their activity will facilitate the development of therapeutic strategies for neurological disorders and diseases.

PI_NAMEs: FURUKAWA, HIROYASU  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Achievement;Agonist;Allosteric Site;Alzheimer's Disease;Animals;antagonist;Antibodies;Antibody Affinity;aspartate receptor;Binding;Brain;Calmodulin;Cell membrane;Cells;channel blockers;Cognition;Complex;Coupled;Cryoelectron Microscopy;Cytoplasmic Protein;Data;delta receptors;desensitization;Development;Electrophysiology (science);Epilepsy;Exhibits;experimental study;Family;fragment X;Glutamate Receptor;Glutamates;Glycine;Glycine Receptors;Grant;Insecta;insight;Ion Channel;Ion Channel Gating;Kainic Acid Receptors;Learning;Ligand Binding Domain;ligand gated channel;Ligands;Lipids;Magnesium;Measures;Mediating;Membrane;Membrane Proteins;Memory;Mental Depression;Molecular Conformation;N-Methyl-D-Aspartate Receptors;Nervous System Disorder;Neuronal Plasticity;neurotransmission;Neurotransmitters;NMDA receptor A1;novel;particle;Pattern;pharmacologic;Pharmacology;Physiological;Play;Preparation;Property;protein complex;Proteomics;Protocols documentation;Psychoses;Public Health;Rattus;receptor binding;Regulation;Research;Resources;Role;Sampling;Schizophrenia;Seizures;Site-Directed Mutagenesis;spatiotemporal;stoichiometry;Stroke;Structure;Synaptic Transmission;System;Technology;Therapeutic;therapeutic development;Transmembrane Domain;Visualization;X-Ray Crystallography

PROJECT_TITLE: Structure and Function of Hetero-Multimeric Ligand-Gated Ion Channels

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Orphan Drug;Pediatric;Rare Diseases

PHR: PUBLIC HEALTH RELEVANCE Single-cell RNA sequencing is powerful technology that can be used to study the cellular makeup of tissue and cell type-specific gene regulation during growth, development, and in disease. In this proposal, we seek to use mosaic human brain tissue comprised of a mixture of cells with and without a genetic variant that causes a rare brain malformation to study the effect of the variant on gene regulation in different types of brain cell types. The long-term goal of the work is to illuminate transcriptomic changes associated with the pathogenic variant that may direct us toward novel and targeted therapies.

PI_NAMEs: HEINZEN, ERIN L (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Affect;Age;AKT Signaling Pathway;AKT3 gene;Alleles;autism spectrum disorder;Autopsy;Brain;brain cell;brain control;brain malformation;Brain region;brain tissue;cell age;Cell Nucleus;Cell Separation;cell type;Cells;Cerebral hemisphere;Classification;Complementary DNA;Coupled;Data;Development;Diagnosis;Disease;disease-causing mutation;DNA;early embryonic stage;Embryo;Epilepsy;Event;FRAP1 gene;Functional disorder;Gene Expression Regulation;Genes;genetic architecture;Genetic Risk;Genetic Transcription;genetic variant;Genomic approach;genomic data;Genomics;Genotype;Goals;Growth;hemimegalencephaly;Human;Individual;Length;Methods;Modeling;mosaic;mosaic analysis;Mosaicism;multimodality;Mutation;Nervous System Disorder;Neurodevelopmental Disorder;neuropsychiatric disorder;neuropsychiatry;novel;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathogenicity;PIK3CA gene;PIK3CG gene;postnatal development;prototype;public health relevance;Recurrence;Reproducibility;Research;Resected;Risk Factors;RNA;Role;Schizophrenia;Signaling Protein;single cell genomics;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;Somatic Mutation;targeted treatment;Technology;Therapeutic;Tissue Sample;Tissues;tool;transcriptome sequencing;transcriptomics;Variant;Work

PROJECT_TITLE: Genotype-informed single cell transcriptomic profiling of mosaic brain tissue

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-W (92)]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Narrative Opioid-use disorder (OUD) and associated overdoses and deaths remain at epidemic levels. This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD. This is critical to improve understanding of brain mechanisms of relapse and is an essential precursor to the development of improved, evidence-based interventions based on known neurobiology.

PI_NAMEs: YIP, SARAH  (contact)

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: Abstinence;Achievement;Adherence;Basic Science;Behavior;Biological;Brain;brain based;brain behavior;Buprenorphine;Cessation of life;chronic pain;Clinical;clinically relevant;cocaine use;cognitive control;cognitive reappraisal;Collection;Complex;criminal behavior;Cues;Data;data archive;Development;Dose;Dropout;dual diagnosis;Educational Status;effective therapy;Epidemic;Evidence based intervention;Exclusion;Female;Fentanyl;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Generations;Hepatitis C Transmission;heroin use;Heterogeneity;HIV/HCV;illicit opioid;improved;Individual;Individual Differences;insight;Intelligence;interest;International;Link;Liquid substance;male;Medical;medication compliance;medication for opioid use disorder;Mental disorders;Methadone;Methods;Modeling;Mood Disorders;mortality;multitask;National Institute of Drug Abuse;National Institute of Mental Health;Nature;negative affect;Network-based;neurobiological mechanism;Neurobiology;neuroimaging;Opioid;opioid epidemic;opioid use;opioid use disorder;Outcome;Overdose;Overdose reduction;overdose risk;Participant;patient retention;Pattern;Performance;Pharmaceutical Preparations;predictive modeling;programs;prospective;Protocols documentation;Public Health;Publishing;Race;Recovery;Relapse;resilience factor;response;Rest;Risk;Risk Factors;Sampling;sex;Source;synthetic opioid;Testing;United States;Validation;Variant;Work

PROJECT_TITLE: Functional connectivity mechanisms of opioid abstinence

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative: Glioblastoma WHO grade IV (GBM) is the most common primary malignant brain tumor in adults with a grim prognosis. The current proposal explores an innovative, novel mitochondrial energetic pathway that is entertained by OGDH in model systems of GBM. Targeting OGDH through the novel compound, CPI613, extends animal survival and enhances the standard of care for GBM and therefore may be a novel treatment for this detrimental disease.

PI_NAMEs: SIEGELIN, MARKUS D (contact)

PROJECT_TERMS: activating transcription factor 3;Adult;Affect;Animals;Apoptotic;Astrocytes;Basal Ganglia;BCL2 gene;BCL2L1 gene;Binding;biological adaptation to stress;Biological Assay;Biological Models;Blood;Blood specimen;blood-brain barrier penetration;Body System;Bone Marrow;Brain;Brain Stem;Carbon;Catabolism;Cell Death;Cell Death Induction;Cells;Cerebellum;Chemistry;chromatin immunoprecipitation;Citric Acid Cycle;Clinical;Clinical Trials Design;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Complete Blood Count;CRISPR library;Data;Dependence;deprivation;Diagnosis;Disease;Electrolytes;Energy Metabolism;Enzymes;Epigenetic Process;experimental study;extracellular;Family member;Foundations;Gene Expression;Genes;Genetic;genome-wide;Glioblastoma;Glioma;Glucose;Growth;Harvest;Heart;Hematology;Hippocampus;Human;In Situ Nick-End Labeling;In Vitro;in vivo;Induction of Apoptosis;inhibitor;innovation;Intestines;Ketoglutarate Dehydrogenase Complex;Kidney;knock-down;Knock-out;Knowledge;Libraries;Liver;loss of function;Luciferases;Lung;Malignant neoplasm of brain;Mediating;Metabolic;Metabolism;mimetics;Mitochondria;Modeling;Mus;Neurosphere;new therapeutic target;novel;Nucleotides;Nutrient;nutrient deprivation;Pancreas;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;pre-clinical;Primary Brain Neoplasms;Prognosis;programs;Proliferating;promoter;Promoter Regions;Proteins;Radiation;Renal function;Research;RNA Interference;Science;screening;Serum;small hairpin RNA;Solid;Source;Spleen;Stains;standard of care;synergism;temozolomide;Testing;Time;Toxic effect;transcription factor;transcriptome;tumor;tumor growth;United States;Up-Regulation;Waste Products;white matter;Work

PROJECT_TITLE: Targeting OGDH for Glioblastoma Therapy

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative: Lassa virus (LASV) is a mammarenavirus highly prevalent in Western Africa, where it is estimated to infect several hundred thousand people yearly, resulting in a high number of Lassa fever (LF) cases, a hemorrhagic fever (HF) disease associated with high morbidity and mortality; there are no US FDA-approved LASV vaccines, and current anti-LASV therapy is limited to off-label use of ribavirin which has limited efficacy. LF has been included on the revised list of priority diseases for the WHO R&D Blueprint, underscoring an urgent need for vaccines to combat LF. The central goal of this application is to test the hypothesis that specific reorganization of the LASV genome can result in live-attenuated vaccine candidates with excellent safety and protective efficacy profiles, while exhibiting an unbreachable attenuation.

PI_NAMEs: DE LA TORRE, JUAN C. (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acceleration;Africa;Animals;Antibody Response;Attenuated;Attenuated Live Virus Vaccine;Attenuated Vaccines;attenuation;biodefense;Case Fatality Rates;Cavia;CBA/J Mouse;Cell Communication;Cell Culture Techniques;Cell Line;Cells;Characteristics;Clinical;Clinical Pathology;Codon Nucleotides;combat;Consensus Sequence;Containment;Cultured Cells;Development;Disease;Dose;Ecology;Ensure;epidemiology study;Exhibits;Exposure to;FDA approved;Generations;Genome;Genomic Segment;Glycoproteins;Goals;Growth;guinea pig model;Hematology;Hospitalization;Human;Immune response;Immunity;Immunization;immunogenicity;in vivo;Individual;Infection;innovation;Intercistronic Region;Knowledge;Lassa;Lassa Fever;Lassa virus;liver function;Lymphocytic choriomeningitis virus;Membrane Glycoproteins;Morbidity - disease rate;mortality;mouse model;Mus;novel;Nucleoproteins;off-label use;Open Reading Frames;pathogen;Persons;Phenotype;Population;prevent;Production;Property;protective efficacy;Proteins;Reassortant Viruses;Recombinants;Renal function;Research;research and development;Ribavirin;RNA;RNA-Directed RNA Polymerase;Safety;safety assessment;safety testing;Serial Passage;Survivors;Syndrome;T-Lymphocyte;Testing;Therapeutic;Training;Untranslated RNA;Vaccinated;Vaccination;vaccine candidate;vaccine platform;Vaccine Production;Vaccines;Vero Cells;Viral;Viral Genome;Viral Hemorrhagic Fevers;Virulence;Virus;Virus Diseases;Western Africa

PROJECT_TITLE: Novel Lassa fever live-attenuated vaccine platform with safety features ensuring unbreachable attenuation

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE During brain development astrocytes promote the formation and maturation of synapses, showing regionally specialized effects. This work investigates the factors that drive functional and molecular regional specializations of astrocytes in the brain, and how this impacts neurons and synapses. Multiple neurodevelopmental disorders including autism display alterations in neuronal and synaptic function, and the findings of this work will uncover pathways that can be targeted to correct these deficits.

PI_NAMEs: ALLEN, NICOLA J (contact)

PROJECT_TERMS: Address;antagonist;aquaporin 4;Astrocytes;autism spectrum disorder;Automobile Driving;Biological Assay;BMPR2 gene;bone morphogenetic protein receptors;Brain;Brain region;Cell Culture Techniques;Cells;Cerebellum;Complex;Cues;Development;Down-Regulation;Electrophysiology (science);Excision;excitatory neuron;experimental study;Family;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Goals;Growth Factor;Heterogeneity;Hippocampus;Immunohistochemistry;In Vitro;in vivo;inhibitor;inhibitory neuron;innovation;insight;Interneurons;Label;MADH4 gene;Mass Spectrum Analysis;Mediator;member;Membrane;Molecular;morphogens;Morphology;Mus;nervous system development;Neurodevelopmental Disorder;Neuroglia;neuronal circuitry;Neurons;Pathway interactions;Play;prevent;Production;programs;Protein Secretion;Proteins;Proteomics;Role;SHH gene;Signal Transduction;single nucleus RNA-sequencing;Source;Synapses;synaptic function;Testing;Thalamic structure;Tissue-Specific Gene Expression;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;Up-Regulation;Work

PROJECT_TITLE: Determining the role of astrocyte BMP signaling in cortical astrocyte heterogeneity

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Bioengineering;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Telehealth

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: PROJECT NARRATIVE There is an important and growing need for tele-health solutions for the diagnosis and management of chronic respiratory diseases such as asthma, COPD, or cystic fibrosis. This proposal will develop a highly innovative, non-invasive, smartphone-based ultrasonic technology to aid in disease diagnosis and in remotely monitoring lung function and airway obstruction.

PI_NAMEs: FORNO, ERICK  (contact);GAO, WEI

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Abbreviations;Acoustics;Acute;Adult;advanced disease;Affect;Age;Air Movements;Airway Disease;airway obstruction;Area;Asthma;biomedical referral center;Bronchopulmonary Dysplasia;Caliber;Calibration;Cause of Death;Cellular Phone;Cessation of life;Characteristics;Child;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Classification;Client;Clinic;Clinic Visits;Clinical;clinical center;cohort;cost;Country;COVID-19;Cystic Fibrosis;deep learning;Detection;Devices;Diagnosis;Disease;disease diagnosis;Disease Management;disorder control;disparity reduction;Early Diagnosis;Emergency department visit;Equipment;Evaluation;evaluation/testing;explainable artificial intelligence;Future;Gender;Health Personnel;Hospitalization;Human;improved;indexing;innovation;invention;Legal patent;Lung;Lung Diseases;lung health;Machine Learning;machine learning algorithm;Measures;Monitor;neural network;new technology;novel;older adult;Oscillometry;Outcome;pandemic disease;Participant;Patient Care;Patient Self-Report;Patients;Perception;Persons;Population;portability;pressure;Primary Ciliary Dyskinesias;Prognosis;prototype;Public Health;Pulmonary Fibrosis;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;Pulmonology;Quality of life;Race;recruit;remote monitoring;Reporting;research clinical testing;respiratory;Respiratory Disease;Risk Reduction;Signal Transduction;Spirometry;Stable Disease;Symptoms;synergism;System;Techniques;Technology;technology development;telehealth;Telemedicine;Testing;tool;Ultrasonics;video chat;Vital capacity;Vulnerable Populations;Work

PROJECT_TITLE: Advancing telemedicine in pulmonology: acoustic-waveform respiratory evaluation (AWARE) via sensing and machine learning on smartphones

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ORG_NAME: JOSLIN DIABETES CENTER

PHR: NARRATIVE Failure of pancreatic β-cells to secrete insulin in response to glucose is a hallmark of diabetes pathogenesis. Under normal conditions, glucose stimulates synthesis of the insulin protein, but prolonged exposure to high glucose during the development of diabetes impairs this critical β-cell function. By discovering new mechanisms by which glucose regulates production of the hormone insulin, this project has the potential to identify novel targets for the development of treatments to halt or delay diabetes progression.

PI_NAMEs: SCHAFFER, JEAN E. (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: 5' Untranslated Regions;Acute;Anabolism;autoimmune pathogenesis;Beta Cell;Binding Proteins;blood glucose regulation;Cell Physiology;cell replacement therapy;Cells;Chronic;Development;Diabetes Mellitus;diabetes pathogenesis;Dissociation;Event;Exposure to;Failure;Functional disorder;Genes;genome-wide;Glucose;glucose metabolism;Golgi Apparatus;Hormones;Human;Hyperglycemia;Impairment;improved;in vivo;Incubated;insight;Insulin;Insulin Resistance;insulin secretion;insulinoma;islet;Knowledge;Mediating;Messenger RNA;Methods;mRNA Translation;new therapeutic target;non-diabetic;novel;Organelles;Peptides;Phenotype;Physiological;Prevention;Process;Production;Proinsulin;Property;Protein Subunits;Proteins;Proteomics;Rattus;Regulation;response;Ribosomal Proteins;ribosome profiling;Ribosomes;RNA-Binding Proteins;Rodent;Rodent Model;Secretory Vesicles;Structure of beta Cell of islet;Testing;therapy development;Toxic effect;Translating;translational impact;Translational Regulation;Translations;Untranslated Regions;Up-Regulation;Work

PROJECT_TITLE: Translational Programming of Beta-cells in Response to Glucose Toxicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-B (02)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

PHR: Polygenic scores (PS) are a mathematic way to try to measure genetic tendency towards a trait, considering a person’s entire genetic makeup, not just one or two genes. So far, PS have mostly been tested in white people and focused on risk of disease, but a major issue in medicine is that individuals often respond differently to medications (some of this being due to differences in genetics) and this is sometimes a particular concern for African American patients who are under-represented in clinical trials and genetic research. The goal of this project is to learn how to create PS for African Americans that can help doctors know which medicines will work best for individual patients based on their genetics.

PI_NAMEs: LANFEAR, DAVID E (contact);WILLIAMS, KEOKI

PROGRAM_OFFICER_NAME: JAQUISH, CASHELL E

PROJECT_TERMS: Admixture;Adrenergic beta-Antagonists;Affect;African American;African American population;African ancestry;Alleles;American;Bayesian Method;biobank;Cardiac;causal variant;Cause of Death;Chronic Disease;Clinical;clinical application;Clinical Trials;cohort;Complex;Data;design;Development;Diabetes Mellitus;Disease;disorder risk;Disparity;Dose;Drug Modelings;drug response prediction;Drug Targeting;European;European ancestry;Family;Gene Frequency;Genes;Genetic;genetic approach;genetic makeup;Genetic Predisposition to Disease;Genetic Research;genetic variant;genome wide association study;genome-wide;Genomics;Genotype;Glycosylated hemoglobin A;Goals;Health;Healthcare;Heart failure;Heritability;Home;Hyperlipidemia;Hypertension;improved;Individual;individual patient;innovation;Intervention;Knowledge;Learning;Linkage Disequilibrium;Mathematics;Measures;Medical;Medical Genetics;Medicine;Metformin;Methods;Minority;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Outcome;Patients;Performance;Persons;Pharmaceutical Preparations;Pharmacogenomics;Phenotype;Population;Population Group;Population Heterogeneity;precision medicine;predicting response;Prevalence;Property;Publications;Publishing;racial population;Recording of previous events;response;Risk;Risk Factors;Sampling;Scoring Method;Structure;Testing;Time;tool;trait;translational applications;Variant;Work

PROJECT_TITLE: Development of Polygenic Scores for Medication Response in Diverse Populations

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ADMINISTERING_IC: OD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: SAN MARCOS

ORG_NAME: TEXAS STATE UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative Aquatic animals are key experimental platforms for biomedical research as models of human disease. This conference will bring together researchers and investigators at different career levels and trainees from the US and around the world to explore the recent discoveries using a wide spectrum of aquatic model organisms, developments in technology and the latest applications of aquatic animals in studying human diseases exemplifying the theme “Discovery Through Diversity”.

PI_NAMEs: LU, YUAN  (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Address;Ambystoma;Animal Model;Animals;Applications Grants;Area;Award;Biomedical Research;Businesses;career;Cephalopoda;Clinical Research;Cnidaria;Coffee;Collaborations;Communities;comparative;Complex;Dedications;design;Development;Diagnosis;disability;Discipline;Disease;disease model;Drug Targeting;drug testing;Educational workshop;Environmental Health;Etiology;Fishes;Fresh Water;Funding;Genetic;Goals;graduate student;Grant;Health;Human;human disease;human model;improved;Information Dissemination;innovation;International;Investigation;Knowledge;Lampreys;marine;meetings;Mentors;Methods;model organism;Modeling;novel;Organism;Outcome;Outcomes Research;Play;posters;Prevention;programs;recruit;Recruitment Activity;Relaxation;Research;Research Methodology;Research Personnel;Research Support;Resources;Role;Science;Scientist;Sea Urchins;Series;Site;stem;Strategic Planning;symposium;System;Techniques;Technology;Texas;therapy development;tool;tool development;Translational Research;Travel;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Woman;Xenopus;Xiphophorus

PROJECT_TITLE: The 11th Aquatic Model for Human Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZOD1 MCST-F (90)]


ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE A diversity of perspectives enriches scientific research, but unfortunately, the existing STEM/health workforce, particularly with respect to research, is among the least diverse. The Promoting Underrepresented and Marginalized Populations’ Advancement in the Sciences (PUMAS) program was conceived to address this issue by providing twelve summer research opportunities in our laboratories for community college students from groups that are traditionally underrepresented in the sciences. The program aims to increase the scientific skills, knowledge, personal confidence, and scientific networks of underrepresented college-aged youth in support of their continued education and eventual careers in STEM, particularly biomedical research and health-related fields.

PI_NAMEs: KRISHNAMURTHY, SUDHA  (contact);OTT, MELANIE MARIA

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Achievement;Address;aged;aluminum sulfate;Area;Awareness;Bachelor's Degree;Biomedical Research;Biotechnology;Cardiovascular Diseases;career;career networking;career preparation;Chemistry;Clinical;cohort;college;Communication;Communities;community college;Continuing Education;Data;Development;Doctor of Philosophy;economic disparity;Education;education research;Educational Activities;Educational workshop;Engineering;Enrollment;Ethnic Origin;Evaluation;experience;Exposure to;Faculty;Fostering;Foundations;Funding;Goals;Graduate Degree;graduate school;graduate student;Grant;Health;Health Personnel;higher education;Individual;innovation;Institution;interest;Internships;Investments;Journals;Knowledge;Laboratories;lectures;Lung Diseases;marginalization;marginalized population;Marketing;Mathematics;medin;meetings;Mentors;Minority Health Research;Molecular Biology;National Research Council;outreach;Participant;podcast;Population;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;posters;Principal Investigator;professor;Program Development;programs;Race;recruit;Research;Research Activity;Research Personnel;Research Project Grants;resilience;Role;Running;Science;Scientist;Series;skills;Structure;Student recruitment;Students;success;summer research;symposium;System;Technology;Time;Training;Training Programs;Underrepresented Populations;Underrepresented Students;United States;United States National Institutes of Health;university student;Vocational Guidance;webinar;Work;Youth

PROJECT_TITLE: Promoting Underrepresented and Marginalized Populations' Advancement in the Sciences (PUMAS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-A (J1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurosciences;Rare Diseases

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative On average a third of the world is infected with the protozoan parasite Toxoplasma gondii that causes chronic inflammation in the brain. This proposal will address the activation of CNS resident astrocytes to determine the subsets involved in crucial aspects of neuroinflammation. Knowledge gained from this work will inform not only our understanding of the balance of infection in the brain but also processes that are involved in many neurological neuroinflammatory diseases.

PI_NAMEs: FIACCO, TODD A;RICCOMAGNO, MARTIN MIGUEL;WILSON, EMMA H (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Ablation;Acute;Astrocytes;astrogliosis;Brain;Cell Nucleus;Cell surface;cell type;Cells;Characteristics;chemokine;Chronic;chronic infection;Clinical Pathology;combinatorial;cytokine;Data;Development;Diphtheria Toxin;Disease;Disparate;Encephalitis;Epigenetic Process;Equilibrium;experimental study;extracellular;falls;Flow Cytometry;Gene Expression;Genetic;genetic manipulation;Glial Fibrillary Acidic Protein;Heterogeneity;Histologic;Immune;Immune response;Inbred BALB C Mice;inducible Cre;Infection;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;inhibitor;Knock-in Mouse;Knowledge;Label;LCN2 gene;Location;Modification;Mus;Natural Immunity;Neuroglia;neuroinflammation;Neurologic;Neurons;neurotoxicity;Neurotransmitters;novel;Outcome;overexpression;Parasite Control;Parasites;Pathologic;Phenotype;Play;Population;Process;Production;programs;Proliferating;promoter;receptor;Regulation;Reporter;Research;Resolution;Role;selective expression;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;STAT1 gene;STAT3 gene;systemic inflammatory response;Tamoxifen;Testing;Time;Tissues;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;Visualization;Work

PROJECT_TITLE: Interrogating the role of reactive astrocytes during Toxoplasma-induced brain inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-X (02)]


NIH_SPENDING_CATS: Aging;Cancer

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: Project Narrative TGF-β family signaling pathways act as central mediators of embryonic development, organ homeostasis, and the body's ability to repair successfully after injury. Importantly, perturbations in the TGF-β signaling axis are linked to a long and growing list of diseases of cardiovascular, respiratory, and skeletal systems, a multitude of cancers, and physiological changes during aging, providing fertile ground for the identification of novel targets and promising new therapies that can fundamentally impact the health of a broad segment of the population. The 2024 FASEB SRC TGF-β Superfamily Conference: Signaling in Development and Disease aims to exploit these exciting discoveries and provide a timely and relevant forum for their presentation, appreciation, analysis, and discussion to inspire and stimulate progress toward ever more effective and targeted therapeutics for TGF-β signaling disorders, while promoting the career development goals of participants, particularly those who are early career scientists, new to the TGF-β field, and/or members of underrepresented groups.

PI_NAMEs: SAVAGE-DUNN, CATHY  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Acceleration;Activins;Adult;Aging;Area;autocrine;Biochemical;Biological;Body System;Cardiovascular Diseases;Cardiovascular system;career;career development;Cells;cohort;Collaborations;Communication;Defect;design;Development;Discipline;Disease;Disparate;Embryo;Embryonic Development;Ensure;Event;experience;experimental analysis;Family;Family member;Fostering;Future;Genetic;genome-wide;Goals;Health;Homeostasis;Human;human disease;Human Pathology;In Vitro;Injury;innovation;interdisciplinary approach;interdisciplinary collaboration;International;Knowledge;Ligands;Link;Maintenance;Malignant Neoplasms;Mediator;member;Mentors;Metabolic;Methods;model organism;Molecular;muscular system;Musculoskeletal;Natural regeneration;Nervous System;Nervous System Disorder;Nodal;novel;novel therapeutics;Oral;Organ;Organism;paracrine;Participant;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Physicians;Physiological;Play;polypeptide;Population;posters;Process;programs;Proteomics;Publishing;Regulation;repaired;Research;Research Activity;Research Personnel;Respiratory System;Role;Scientist;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Skeletal system;Specialist;stem cells;Structural Biologist;success;symposium;System;targeted treatment;Testing;TGF Beta Signaling Pathway;Therapeutic;tissue regeneration;tissue repair;Tissues;Training;transcriptomics;Transforming Growth Factor beta;Underrepresented Populations;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The septal complex critically regulates a number of behavioral processes related to motivation and emotion yet very little is known about the mechanisms that govern its development. Our studies will identify the key genetic and molecular pathways that underlie the developmental logic for the functional specialization of diverse neuronal cell types in the septum.

PI_NAMEs: HARWELL, COREY C (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Address;Affective;Anatomy;Anxiety;anxiety-related behavior;anxiety-related disorders;basal forebrain;Behavior;Behavioral;biological adaptation to stress;Bipolar Disorder;Brain region;Cell surface;cell type;Cells;cholinergic;Classification;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;conditional knockout;Development;early life stress;Electrophysiology (science);Emotional;emotional behavior;Emotions;Enkephalins;Exhibits;Functional disorder;Funding;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Transcription;Goals;Hippocampus;Hypothalamic structure;Knockout Mice;Lateral;Lateral Septal Nucleus;Logic;loss of function;Medial;Mediating;Mental Depression;Mental disorders;Molecular;Morphology;Motivation;mouse genetics;Mus;Mutagenesis;nerve supply;neural;neural circuit;Neurons;Neuropeptides;neuropsychiatric disorder;novel;optogenetics;Pathway interactions;Play;Process;programs;Prosencephalon;receptor;Research Proposals;Rest;Role;Schizophrenia;Septal Nuclei;social;Social Behavior;Specific qualifier value;Stress;Subgroup;Synapses;Testing;transcription factor;transcriptomics;Trauma;urocortin;Viral

PROJECT_TITLE: Temporal Specification of Basal Forebrain Circuitry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-V (02)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE This project examines how red blood cells contribute to the severe inflammatory response that occurs after exposure to cardiopulmonary bypass (CPB) since this response impairs the function of all most every organ in the body, especially in infants. We will test if reducing the exposure to blood products reduces CPB induced inflammation. The resulting data will be used to help new ways of protecting children during cardiac surgery.

PI_NAMEs: DEL ALAMO, JUAN CARLOS ;NIGAM, VISHAL  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, BRYANNA NICOLE

PROJECT_TERMS: Adrenal Cortex Hormones;Air;Animal Model;Biomechanics;Blood;blood product;Blood Viscosity;Cardiac Surgery procedures;Cardiopulmonary Bypass;cell injury;Cells;Child;Childhood;Circulation;Clinical;Clinical Research;Computer Simulation;Congenital Heart Defects;crystalloid;Cytolysis;Data;design;Embolism;Erythrocytes;Erythrophagocytosis;experience;experimental study;Exposure to;Functional disorder;Goals;Health Care Costs;Hemodilution;Hemolysis;Impairment;improved outcome;In Vitro;Infant;Inflammation;Inflammatory;Inflammatory Response;injured;insight;Investigation;irradiation;Knowledge;Leukocytes;Liquid substance;Literature;Mechanics;Mediating;Microfluidic Microchips;Molecular;Molecular Target;monocyte;Morbidity - disease rate;mortality;Myeloid Cell Activation;Myeloid Cells;Natural Immunity;Neonatal;neonatal patient;novel;novel strategies;Operative Surgical Procedures;Organ;Outcome;palliation;Pathway interactions;Patients;pediatric patients;Phenotype;Physiological;porcine model;prevent;Process;repaired;Research;response;Sampling;shear stress;standard of care;Stimulus;Stress;synergism;systemic inflammatory response;Techniques;Temperature;Testing;Translating;Trauma;treatment strategy;Tube

PROJECT_TITLE: Mechanisms by which red blood cells contribute cardiopulmonary bypass associated inflammation

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Evident in its name, Helicobacter pylori is a helical-rod shaped bacterium that colonizes the human stomach causing clinical outcomes that range from mild gastritis to peptic ulcer and gastric cancer. We discovered genes that promote helical cell shape through modification of the cell wall. Study of how these cell wall modifications promote helical cell shape and the ability of the bacterium to live in its niche will help us better understand how this bacterium causes disease and uncover new ways to inhibit infection.

PI_NAMEs: SALAMA, NINA  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Bacteria;Binding;Campylobacter;Cancer Etiology;Caulobacter crescentus;cell envelope;cell fixing;Cell membrane;Cell Shape;Cell Wall;Cells;Chronic;chronic infection;Clinical;Clinical Pathology;Complex;Cryo-electron tomography;Cytoskeletal Proteins;Data;Defect;Disease;Endopeptidases;Enzymes;Filament;Gastritis;gene discovery;Generations;Genes;Genetic Polymorphism;Helicobacter pylori;Human;In Situ;Infection;Inflammation;Integral Membrane Protein;Label;Link;Maintenance;malignant stomach neoplasm;Maps;Measures;Methods;Microbial Biofilms;Minor;Modeling;Modification;Morphology;mortality;Motility;Motion;mutant;N-Acetylmuramoyl-L-alanine Amidase;Names;Nutrient;Organism;Outcome;particle;Pathogenesis;Pattern;Peptic Ulcer;Peptidoglycan;persistent bacteria;polymerization;Polymers;Population;preference;pressure;Protein Dynamics;Proteins;Radiation;Rod;Role;Shapes;Side;Stomach;Testing;tool;Treatment Protocols;uptake;Variant;Vibrio;Vibrio cholerae;Work

PROJECT_TITLE: Mechanisms and consequence of helical shape generation in Helicobacter pylori

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-L (02)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE A recurring difficulty in the treatment of drug addiction is the reinstatement of drug use even after a lengthy abstinence period. The purpose of this proposal is to exploit recent technical advancements in order to analyze and discover the neuronal adaptation in specific neural circuitry in the prefrontal cortex for the self-administration of cocaine. We believe that the exploration of the circuit mechanisms for drug seeking after withdrawal will be extremely useful for creating a framework for researching drug addiction in a circuit-specific manner and for devising a treatment strategy for drug addiction.

PI_NAMEs: LIM, BYUNGKOOK  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;addiction;Addictive Behavior;Area;Attention;Automobile Driving;Axon;Behavior;Brain;cell type;Chronic;Cocaine;cocaine seeking;cocaine self-administration;Complex;Cues;Decision Making;Deep Brain Stimulation;Development;Drug abuse;Drug Addiction;drug craving;drug development;Drug Modulation;Drug usage;Emotional;experience;Exposure to;Extinction;Fiber;genetic manipulation;Goals;Head;Impulsivity;Individual;Interneurons;Interruption;Measurement;Medial;Memory;Microscopy;Molecular;Monitor;Morphine;multi-photon;neural circuit;neuroadaptation;Neurons;Output;Parvalbumins;Pharmaceutical Preparations;Photometry;Photons;physical state;Play;Population;Prefrontal Cortex;Prevalence;Psychological Stress;psychostimulant;Recurrence;Relapse;Reporting;Research;Resolution;response;reward circuitry;Rewards;Role;Self Administration;Short-Term Memory;Signal Transduction;Site;Somatostatin;Substance abuse problem;substance use;System;transmission process;treatment strategy;two photon microscopy;Vasoactive Intestinal Peptide;Withdrawal

PROJECT_TITLE: Differential Roles of Prefrontal Cortical Interneurons in Drug Seeking after Withdrawal

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: PROJECT NARRATIVE Engineering a patient’s own immune cells to fight cancer is one of the most promising new advances in cancer therapy, yet this strategy has been limited by a lack of tumor-specific surface targets. Here we aim to advance the development and capabilities of a technology we invented, called “structural surfaceomics”, to characterize the set of potential tumor-specific surface antigens defined by their 3-dimensional protein conformation. The long term goal of this proposal is to directly spur the development of new cancer therapies for patients currently in need.

PI_NAMEs: HUANG, LAN ;WIITA, ARUN P. (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: 3-Dimensional;Acute Myelocytic Leukemia;Address;Adoption;Advanced Development;Adverse effects;Antigen Targeting;Antigens;B-Lymphocytes;Biochemistry;Biological Models;biological systems;Biology;cancer cell;cancer immunotherapy;cancer therapy;CD19 gene;Cell membrane;Cell surface;Cell Therapy;Cells;cellular engineering;Cellular immunotherapy;Cessation of life;Chemicals;chimeric antigen receptor T cells;Clinical;clinical investigation;Clinical Pathways;clinical translation;Communication;Complex;Computer software;crosslink;Custom;Data;Data Set;design;Development;Disease;Drug Targeting;efficacious treatment;engineered T cells;Engineering;Epidermal Growth Factor Receptor;Epitopes;ERBB2 gene;exhaust;fighting;Funding;Goals;Hematopoietic Neoplasms;Immune;Immunotherapeutic agent;Immunotherapy;improved;innovation;Institution;Integrins;invention;Joints;Knowledge;leukemia;Malignant neoplasm of brain;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Spectrum Analysis;Membrane Proteins;Messenger RNA;Methodology;Methods;Modality;Modeling;Molecular Conformation;MS4A1 gene;nanobodies;Nature;neoplastic cell;new technology;new therapeutic target;Normal tissue morphology;novel;Patients;preclinical development;Primary Neoplasm;Protein Conformation;Proteins;Proteome;Proteomics;Recombinant Antibody;Relapse;Research;Research Personnel;resistance mechanism;Sampling;Site;Solid Neoplasm;Speed;structural biology;Structure;Surface;Surface Antigens;T cell therapy;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;therapy development;Toxic effect;transcriptome;tumor;Tumor Tissue;Validation;Work

PROJECT_TITLE: Structural surfaceomics to probe conformation-selective immunotherapy targets

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DMPC-J (90)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The rates of dual use of cigarettes and electronic cigarettes are increasing, but there are no evidence-based treatments for such dual users. This innovative research will compare the effectiveness of two cessation medications (varenicline vs. nicotine patches), two counseling interventions (focusing on quitting smoking and quitting e-cigarettes vs. focusing exclusively on quitting smoking), and two counseling durations (1 vs. 4 sessions) in helping dual users quit smoking. These findings could inform clinical treatment decisions for dual users.

PI_NAMEs: BAKER, TIMOTHY B;PIPER, MEGAN E (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Abstinence;Behavioral;Biochemical;Biological Assay;Carbon Monoxide;Cause of Death;Cellular Phone;Cessation of life;Characteristics;Cigarette;cigarette smoking;cigarette user;Clinical Treatment;Clinical Trials;combustible cigarette;combustible tobacco;compare effectiveness;coping;Coping Skills;Cotinine;Counseling;craving;Cues;Data;demographics;Dependence;Disease;e-cigarette cessation;Ecological momentary assessment;effective intervention;efficacy evaluation;Electronic cigarette;electronic cigarette use;Electronic Nicotine Delivery Systems;Enrollment;Evidence based treatment;follow up assessment;follow-up;Goals;Harm Reduction;Individual;innovation;Intervention;Laboratories;Malignant Neoplasms;Measures;Mediating;Mediator;Menthol;multiphase optimization strategy;nicotine exposure;nicotine patch;Outcome;Participant;Pattern;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Policy Maker;Prevalence;primary outcome;Public Health;Publishing;Race;Randomized;Recording of previous events;Relapse;Reporting;Research;Rewards;Sampling;screening;Self Efficacy;Services;skills;Smoke;Smoking;smoking abstinence;smoking cessation;smoking cue;Societies;Testing;Time;Tobacco use;translational potential;treatment effect;trend;Urine;vaping;varenicline;Withdrawal Symptom;Work

PROJECT_TITLE: Dual Use Cessation: A MOST Screening Trial to Identify Effective Interventions to Help People Who Smoke and Vape

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-J (02)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse;Underage Drinking

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: LOYOLA MARYMOUNT UNIVERSITY

PHR: Project Narrative The proposed project develops and evaluates the efficacy of Digitally Prompted Parenting (DPP), a text- message parent-based intervention (PBI) for parents of incoming college students that is designed to prevent heavy episodic drinking and the development of risky drinking behavior that often occurs in the first semester in college. Unlike existing PBIs which are delivered before students arrive on campus, DPP leverages existing parent-student communication via texts prompting parents to send tailored risk-reducing messages on days and times when alcohol use is common among college students. The brevity of text messages and the simplicity of the task that parents are asked to engage in makes DPP cost-effective and easy to disseminate, while increasing the likelihood that parents engage with and implement the intervention content in a way that translates into stronger effects on drinking relative to the more demanding and time-consuming standard PBIs.

PI_NAMEs: LABRIE, JOSEPH W. (contact);TRAGER, BRADLEY MARCK

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: active control;Address;Adult Children;Affect;African American;alcohol consequences;Alcohol consumption;alcohol intervention;Alcohols;Asian;Attitude;Belief;binge drinking;Black race;Calendar;Caucasians;Cellular Phone;Child;Child Rearing;college;Communication;compare effectiveness;Consumption;cost effective;critical period;Data;design;Development;digital;drinking;drinking behavior;efficacy evaluation;emerging adult;Ethnic Origin;Ethnic Population;Fathers;Feedback;financial incentive;Focus Groups;Future;Gender Role;handbook;Heavy Drinking;high risk;high risk drinking;Hispanic;Home;Intervention;Latinx;Literature;matriculation;Measures;Mechanics;Mental Health;Modeling;Mothers;National Institute on Alcohol Abuse and Alcoholism;Native Americans;novel;Outcome;parental role;parenting intervention;Parents;Participant;Patient Self-Report;Performance;permissiveness;personalized normative feedback;Phase;pilot test;Play;Population;prevent;programs;Public Health;Race;racial population;Reading;Research;Risk;Risk Reduction;Role;Sampling;Self Efficacy;sex;Stress;student drinking;Students;Surveys;tailored text messaging;Testing;Text;Text Messaging;theories;Time;Translating;treatment duration;underage drinking;university student;Voice;web platform;Work

PROJECT_TITLE: Digitally Prompted Parenting: A Text Message Parent-Based Alcohol Intervention for Incoming College Students


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: NARRATIVE This conference is organized as a response to well-articulated research needs expressed by retired gold/uranium miners and community leaders in South Africa since May 2021, as well as by UNM HSC COP and UNM METALS SRP community partners, the Navajo Nation (Diné Bikéyah) and the Pueblo of Laguna (K’awaika). The conference will unite in-person African and Native people affected by uranium developments worldwide and share community engagement goals and practices of the UNM METALS Superfund Research Center (SRP) in support of NIEHS’s programmatic mission. The conference will bring together community knowledge holders, researchers to discuss findings of ongoing environmental health and risk assessment research conducted in their respective communities, cultivate collaborative community partnerships for future research as well as actions promoting healing, social networking, and environmental justice for marginalized people exposed to uranium mining.

PI_NAMEs: ERDEI, ESTHER  (contact)

PROGRAM_OFFICER_NAME: TROTTIER, BRITTANY

PROJECT_TERMS: Affect;African;Articulation;Chemicals;climate change;Communities;community center;community engaged research;community engagement;community partners;community partnership;community-centered;Crow Tribe;Development;Diné Nation;Education;empowerment;Environmental Health;environmental justice;experience;Exposure to;Food;Funding Opportunities;Goals;Gold;Growth;Growth and Development function;healing;health assessment;health literacy;Indigenous;innovation;interest;International;Intervention Studies;Knowledge;Learning;Lived experience;marginalization;marginalized population;meetings;Methods;Mining;Mission;National Institute of Environmental Health Sciences;Native American community;Native-Born;Navajo;Participant;Persons;Public Health;Pueblo Race;remediation;Research;Research Personnel;Resources;response;Risk Assessment;Science;Site;social;Social Network;South Africa;South African;Superfund;symposium;Testing;Toxic effect;Tribes;Trust;Uranium;Video Recording;Visit;wasting;web site

PROJECT_TITLE: Shared Lived Experiences of Uranium-Exposed Communities - A Global Discussion Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-W (R3)]