NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Microglia, tissue-resident macrophages of the brain, respond to damage and have been implicated as a key cellular player in the context of aging and age-related neurological disorders, including Alzheimer’s disease (AD). We have found that proteins present within the systemic environment regulate various cellular and molecular processes within the brain in the context of aging and AD pathology. The proposed experiments will define the process by which specific proteins alter microglial function in the context of aging and AD to enhance our understanding of blood-brain communication, which will inform subsequent therapeutic approaches in this space.

PI_NAMEs: HEMMER, BRITTANY MARIE (contact)

PROJECT_TERMS: Age;age related;age-related disease;aged;Aging;aging brain;aging population;aging process;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;amyloid pathology;animal old age;Blood;Brain;Cells;cellular targeting;Central Nervous System;Chronic;cognitive change;cognitive performance;Communication;confocal imaging;Confocal Microscopy;cytokine;Data;Dendritic Spines;Development;Disease;Disease associated microglia;Disease Marker;Disease Progression;effective therapy;Environment;Exhibits;experience;experimental study;Exposure to;extracellular;Extracellular Matrix;Extracellular Protein;Extracellular Space;Functional disorder;Gene Expression;Gene Expression Profile;Genes;glial activation;Hippocampus;Homeostasis;Human;improved;in vivo;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;insight;Intercellular Fluid;Long-Term Potentiation;Macrophage;Maintenance;Matrix Metalloproteinases;Mediating;Memory;Metabolism;Methods;Microdialysis;Microglia;Modeling;Molecular;Morphology;mouse model;Mus;Myeloid Cells;Nerve Degeneration;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;Neuroimmune;Neurons;novel strategies;old mice;Organ;Pathologic;Pathology;Phagocytosis;Phenotype;Plasma;Play;Process;Proteins;Regulation;Rejuvenation;Resolution;response;restoration;Risk Factors;Role;Saline;senescence;superresolution microscopy;Surveys;Synapses;Synaptic plasticity;targeted treatment;Testing;Therapeutic;therapy development;Thromboplastin;Tissue Inhibitor of Metalloproteinases;Tissues;transcriptome sequencing;wasting;Wild Type Mouse;Work;Youth

PROJECT_TITLE: Regulation of microglial function by blood-borne factors


ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative This proposal seeks to determine how targeting molecular and circuit mechanisms of Dyrk1a function in the adult brain harbors potential to reverse impact of developmental loss of Dyrk1a on social cognition in Autism Spectrum Disorders.

PI_NAMEs: SAHAY, AMAR  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Acute;Adult;Affect;autism spectrum disorder;Behavior;Biological Process;Brain;cell type;Cells;Child;Chronic;Complement;Data;dentate gyrus;Development;Disease;Down-Regulation;Electrophysiology (science);Enhancers;Exhibits;exome sequencing;experience;gene therapy;Genes;Genetic;Genetic Epistasis;Genetic study;granule cell;Hippocampal Mossy Fibers;Hippocampus;Impaired cognition;Impairment;in vivo;inhibitory neuron;Learning;loss of function;loss of function mutation;Mediating;Memory;Memory impairment;memory recognition;mimetics;model of autism spectrum disorder;Modeling;Molecular;Molecular Target;mossy fiber;mouse model;Mus;mutant;Neurodevelopmental Disorder;Neuronal Plasticity;Neurons;optogenetics;Parvalbumins;patch clamp;Pathway interactions;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;recruit;repetitive behavior;Risk;Role;Seizures;social;Social Behavior;social cognition;Specificity;Synapses;System;Testing;Tyrosine Phosphorylation;United States;Viral

PROJECT_TITLE: Hippocampal synaptic and circuit mechanisms mediating Dyrk1a functions in social cognition

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: GUELPH

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF GUELPH

ORG_STATE: ON

ORG_ZIPCODE: N1G 2W1

PHR: Project narrative  This work will increase capacity and capability of veterinary diagnostic laboratories through use of harmonized analytical methods to combat antimicrobial resistance and to swiftly respond to animal foodborne illness outbreaks. It started and will continue by laying the important groundwork in establishing antimicrobial susceptibility trends in bacterial isolates recovered from companion animals across the USA and Canada and by submitting whole genome sequences (WGS) of selected isolates to National Center for Biotechnology Information (NCBI). By gathering all information and performing WGS veterinary laboratories are building their capacity for timely responses to outbreaks while at the same time providing significant amount of data available to general scientific community through NCBI for future work (i.e., monitoring antimicrobial resistance trends, exploring virulence factors, tracing outbreak sources, etc.).

PI_NAMEs: SLAVIC, DURDA  (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: Vet-LIRN antimicrobial resistance surveillance through collection of AMR data and whole genome sequencing of isolates from Canadian provinces


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: DALLAS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Deficits in social communication, including delays, disruptions or regression of speech and language, are important diagnostic features of many genetic disorders. Nonetheless, the genetic basis for vocal learning and imitation remain poorly understood. This research will establish the first large scale genetic screen in a vocal learning species to identify the genetic basis for vocal learning and vocal imitation.

PI_NAMEs: ROBERTS, TODD F (contact);TAKAHASHI, JOSEPH S

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Adult;Animals;Area;Artificial Insemination;autism spectrum disorder;Behavior;Behavioral;Birds;Brain;Breeding;Cell Line;Child;Chromosome Mapping;Communication impairment;Complex;Dedications;Development;Developmental apraxia;developmental disease;Diagnostic;Dominant Genetic Conditions;Environment;Ethylnitrosourea;experience;forward genetics;Foundations;FOXP1 gene;FOXP2 gene;gene discovery;gene function;gene replacement;Gene Targeting;Gene Transfer Techniques;Genes;Genetic;genetic approach;Genetic Diseases;Genetic Drift;genetic linkage analysis;genetic manipulation;genetic pedigree;Genetic Screening;genetic signature;Genomics;Germ Lines;Goals;Human;Individual;innovation;insight;Laboratories;Language;Language Development;learned behavior;Learning;Maps;Methods;Modeling;Molecular;Motor;Mutagenesis;Mutagens;Neurobiology;Neurodevelopmental Disorder;neurogenetics;novel;Parents;Persons;Phenotype;Play;Polygenic Traits;Primates;Production;Research;Rett Syndrome;reverse genetics;Role;Sensory;Shapes;social;Social Behavior;social communication;Social Development;social skills;Songbirds;Speech;Speech Development;Speech Disorders;Spermatogonia;stem cells;Technology;Testing;tool;trait;Transgenic Model;Transgenic Organisms;transmission process;Transplantation;Vertebrates;vocal learning;vocalization;zebra finch

PROJECT_TITLE: The Genetic Basis of Vocal Learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative In support of the FDA CVM antibiotic stewardship plan, our group has actively supported the technological capability and capacity of Vet-LIRN laboratories to perform genomic techniques for real-time antimicrobial resistance surveillance in a consistent and reliable manner. Now that a significant amount of data for E. coli in dogs is available and has brought attention to serious concerns, we propose to perform a comparative genomics study designed to assess the potential of E. coli in dogs to carry loci that might confer resistance to antibiotics and/or cause disease in people. We will also characterize the repertoire of coronaviruses in companion animals, conduct evolutionary genetic analyses that will provide an assessment of their potential risks for zoonotic transmission, and provide training in viral whole genome sequencing to other network laboratories.

PI_NAMEs: GOODMAN, LAURA BRUNENGRABER (contact);STANHOPE, MICHAEL J

PROJECT_TITLE: Assessment of Zoonotic Risk of Emerging Infections in Companion Animals


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: The TL1 Core is a critical component of the Georgia Clinical & Translational Science Alliance (Georgia CTSA) and designed to respond to the needs of training a new and diverse generation of clinical and translational  research (CTR) investigators focused on improving the health of diverse communities. The TL1 Core provides didactic and mentored CTR training to a diverse group of predoctoral and postdoctoral trainees at the four  partner Georgia CTSA institutions (Emory University, Georgia Institute of Technology, Morehouse School of  Medicine, and University of Georgia). The TL1 Core (in collaboration with the KL2 Core) also provides CTR  training infrastructure at the Georgia CTSA institutions through support of a Master of Science in Clinical  Research (MSCR) program and a Certificate Program in Translational Research (CPTR).

PI_NAMEs: BLUMBERG, HENRY M (contact);MICHOPOULOS, VASILIKI

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: Academia;Address;African American;Awareness;behavioral and social science;Biomedical Research;career;career development;certificate program;Clinical;Clinical Research;Collaborations;Communities;community engagement;Community Health;COVID-19 pandemic;Dedications;Degree program;Demography;design;Development;Dissemination and Implementation;dissemination science;Education;education research;Educational Curriculum;Entrepreneurship;Equity;experience;Federal Government;Funding;Future;Generations;Goals;Grant;Health;health disparity;health equity;Hispanic;Human;implementation science;improved;Individual;Industry;innovation;Institution;Joints;Leadership;Link;Master of Science;Mentors;Mentorship;Methods;Minority Groups;minority trainee;Modeling;Morehouse School of Medicine;National Research Service Awards;Pathway interactions;Population Heterogeneity;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Personnel;Research Training;Role;Science;skills;Technology;TNFSF15 gene;tool;Training;Training and Education;Training and Infrastructure;training opportunity;Training Programs;Translational Research;translational research program;Translations;Underrepresented Minority;United States National Institutes of Health;Universities;virtual;Woman

PROJECT_TITLE: J. NRSA Training Core


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

ORG_CITY: MINNEAPOLIS

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Bacterial adhesins contribute to formation of biofilms – ubiquitous structures with great importance for public health. Antigen type I/II (AgI/II) adhesins are found in various Streptococcus species and are known to mediate binding to several host molecules and other oral microbes. This proposal will identify roles of AgI/II adhesins in surface attachment and biofilm formation of Streptococcus gordonii, potentially identifying conserved mechanisms that may be targeted for manipulation of Streptococci-containing biofilms.

PI_NAMEs: AITKEN, SARAH  (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Acetylation;Affect;Antigens;Bacterial Adhesins;Bacterial Attachment Site;bacterial genetics;Binding;Biology;Carbohydrates;career;Cell surface;Cells;clinical application;Communicable Diseases;Communities;Community Developments;Complex;Custom;Data;dental biofilm;Dental caries;Dental Pellicle;Dental Plaque;Dentistry;Dentists;Development;Disease;Electrophoretic Mobility Shift Assay;Environment;experience;experimental study;Family;gene repression;genetic approach;Genetic Transcription;Glycoproteins;Growth;Health;Human;improved;In Vitro;in vivo;Knowledge;Lead;Life Style;Link;Lysine;Measures;Mediating;Microbe;microbial;Microbial Biofilms;microbial community;Modeling;Molecular;Mucins;Mucous Membrane;Mutation;novel therapeutics;Oral;Oral cavity;oral commensal;oral infection;Peptides;Periodontitis;Phosphotransferases;Play;Point Mutation;polymicrobial biofilm;Polysaccharides;promoter;Protein Acetylation;Protein Family;Proteins;Public Health;Recombinants;Regulation;Regulatory Pathway;Reporting;Research;response;Role;Saliva;salivary mucins;Scientist;sensor;sensor histidine kinase;Specificity;Streptococcus;Streptococcus gordonii;Structure;Surface;surface coating;System;Testing;tooth surface;Training;Transcriptional Regulation;Vertebral column

PROJECT_TITLE: Binding specificity and transcriptional regulation of antigen I/II adhesins in Streptococcus gordonii

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Diabetes;Health Services;Mental Health;Nutrition;Obesity;Physical Activity;Prevention;Rehabilitation

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative  Type 2 diabetes and overweight/obesity are often described as accelerators of aging due to associations with decreased lifespan, increased disability risk, and reduced health-related quality of life. It is unknown whether lifestyle interventions delivered mid-life may lead to better health profiles in later life for individuals with these conditions. We are responding to RFA-AG-21-028 to continue following a cohort of individuals who had been enrolled in a 10-year randomized clinical trial to examine the impact of lifestyle intervention on their health, function, and health care needs later in life.

PI_NAMEs: ESPELAND, MARK ANDREW (contact);WAGENKNECHT, LYNNE E

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Adult;adult obesity;Age;age related;Aging;aging related;Ancillary Study;Behavior;Behavior Therapy;Behavioral;Behavioral trial;Biological Aging;Blood Pressure;Body Weight decreased;Caloric Restriction;Cardiovascular Diseases;Caring;Chronic Disease;Chronic Kidney Failure;Clinical;cognitive function;cohort;comparison intervention;Control Groups;cost;Counseling;Data;depressive symptoms;design;Development;Diabetes Mellitus;Diet;disability;disability risk;Education;Elderly;Enrollment;Ethnic Origin;Event;Face;follow-up;frailty;Gender;Glycosylated hemoglobin A;Goals;Health;health care service utilization;health related quality of life;Health Status;Healthcare;healthy aging;Heterogeneity;high risk;improved;indexing;Individual;Insulin;Interest Group;Intervention;intervention effect;Investigation;late life;Life;Life Experience;life span;lifestyle intervention;Long-Term Effects;Measures;Mediating;Medicare;Mental Depression;Metabolic;Metformin;middle age;Monitor;multiple chronic conditions;Non-Insulin-Dependent Diabetes Mellitus;Obesity;older adult;Older Population;Outcome;Overweight;Participant;Pharmaceutical Preparations;Phenotype;Physical activity;Physical Function;Positioning Attribute;Predictive Factor;Prognosis;Protocols documentation;Race;Randomized;Randomized Controlled Clinical Trials;randomized, clinical trials;resilience;Resources;response;Risk Factors;Risk Reduction;sex;Source;Specific qualifier value;study population;Subgroup;Syndrome;Telephone Interviews;therapy design;Time;Translating;United States;Weight;Weight maintenance regimen

PROJECT_TITLE: Action for Health in Diabetes (Look AHEAD) Extended Follow-up (LA-E2)


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

PHR: An exploratory research project will develop deep-UV Raman microscopic hyperspectral imaging for molecular and/or cellular analysis of biological tissues with a goal of the early detection, improved screening, and clinical diagnostics of cancer. The proposed strategy offers a novel enabling technology to elucidate basic mechanisms underlying cancer initiation and progression and will facilitate early cancer detection, screening, and/or cancer risk assessment, by differentiating, evaluating and/or observing cancer stages and progression. The overall approach targets the wide spread of the technology, its relatively low-cost and seamless transition to clinical setting. The research study will also provide a roadmap to develop a new advanced approach for studying a variety of bone-related tumors and identify novel preclinical and clinical assays.

PI_NAMEs: BEREZIN, MIKHAIL Y.;YAKOVLEV, VLADISLAV V. (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Acceleration;accurate diagnostics;Address;Algorithms;Animal Model;Artificial Intelligence enhanced;Binding Proteins;Biological;Biological Assay;Biopsy;bone;bone imaging;Bone neoplasms;Bone Tissue;Breast Cancer cell line;Cancer Biology;Cancer Detection;Cancer Diagnostics;cancer imaging;cancer initiation;cancer risk;cellular imaging;Chemicals;Clinical;clinical diagnostics;commercialization;Computer software;cost;data acquisition;Data Analyses;deep field survey;deep learning;deep learning algorithm;Detection;detection sensitivity;Development;diagnostic tool;drug discovery;Early Diagnosis;Electronics;Ensure;follow-up;Frequencies;Goals;Image;Image Analysis;imaging modality;imaging platform;imaging system;improved;Individual;instrument;Knowledge;Label;Legal patent;Lesion;Libraries;Machine Learning;machine learning algorithm;Malignant Neoplasms;Metastatic Neoplasm to the Bone;Methods;Microscope;Microscopic;Microscopy;Molecular;molecular imaging;Molecular Structure;multi-scale imaging data;novel;novel diagnostics;novel strategies;optical imaging;Optics;Pathology;Pathway interactions;Performance;Pharmaceutical Preparations;Phase;practical application;pre-clinical;prevent;Process;prognostic value;programs;Protein Conformation;protein structure;prototype;Raman Spectrum Analysis;Research;Research Project Grants;Research Proposals;research study;Resolution;response;Risk Assessment;screening;Screening for cancer;Sensitivity and Specificity;Signal Transduction;Specificity;spectroscopic imaging;Speed;success;Techniques;Technology;Time;Tissue Sample;Tissues;tool;tumor;tumor progression;Variant

PROJECT_TITLE: Molecular and cellular imaging of bone biopsies using AI augmented deep UV Raman microscopy


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: HEKTOEN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: IL

PHR: PROJECT NARRATIVE The purpose of this proposal is the renew the Minority-Underserved NCI Oncology Research Program at John H. Stroger, Jr. Hospital of Cook County in Chicago. The continuation of this valuable program is critically important to our minority patient population as it offers access to cancer care strategies that would not otherwise be available at our safety-net institution. It also contributes to the diversity of the study population in the NCTN.

PI_NAMEs: TAMKUS, DEIMANTE  (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: African American;anti-cancer research;base;Blood specimen;cancer care;Cancer Control;Cancer Patient;care coordination;care delivery;Caring;Chicago;Clinical Research;Clinical Trials;Communities;Community Care Networks;cooking;County;design;early onset;Eastern Cooperative Oncology Group;Female;Fostering;Growth;Head and Neck Cancer;Health;Hematologic Neoplasms;Hospitals;Illinois;improved;Incidence;Institution;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Managed Care;Methods;Minority Groups;minority patient;Morbidity - disease rate;mortality;multidisciplinary;new technology;Oncology;patient derived xenograft model;patient population;Patients;Prevention;Principal Investigator;process improvement;programs;Reproductive History;Research;Research Project Grants;safety net;Site;Source;study population;survivorship;symptom science;System;tertiary care;Tissue Sample;Translational Research;underserved minority;Underserved Population

PROJECT_TITLE: Stroger Hospital of Cook County (SHCC) MU-NCORP Renewal


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: Project Narrative Chemical modulation of T cells remains a clinical objective in a spectrum of disorders from cancer to transplant immunosuppression. Our work to date implicates DNA-PKcs as a critical regulator of CD4+ and CD8+ T cell activity. The goal of our proposal is to further elucidate mechanisms by which DNA-PKcs impacts T cell response to antigen in order to better understand how targeting this kinase can translate into clinical benefit.

PI_NAMEs: BURDINE, MARIE SCHLUTERMAN (contact);KOSS, BRIAN

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: adaptive immune response;Adaptor Signaling Protein;Affect;Alanine;Allogenic;Antigens;Autoimmune Diseases;B-Lymphocytes;Binding Proteins;cancer immunotherapy;cancer therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell membrane;Cell Physiology;Cell Separation;Cells;Cellular Immunity;Chemicals;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Communicable Diseases;congenic;Coupled;cytokine;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Development;Disease;DNA Repair;DNA-dependent protein kinase;DNA-PKcs;Effectiveness;experimental study;Flow Cytometry;Follow-Up Studies;Gene Expression;Genetic;genetic approach;Genetic Transcription;Goals;Immunity;immunogenic;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;inducible Cre;Inflammatory;inhibitor;insight;Investigation;Knock-out;Laboratories;Laser Scanning Confocal Microscopy;loss of function mutation;LoxP-flanked allele;Malignant Neoplasms;Mass Spectrum Analysis;Mature Lymphocyte;Mature T-Lymphocyte;MC38;Mediating;Mediator;Metabolism;model design;Modeling;Molecular;mouse model;Mouse Strains;Mus;Mutation;novel;novel therapeutic intervention;nuclear factors of activated T-cells;organ transplant rejection;Ovalbumin;Patients;pharmacologic;phosphoproteomics;Phosphorylation;Phosphotransferases;Production;programs;Proliferating;Proteins;Proteomics;PTPRC gene;receptor binding;Receptor Signaling;Regulation;Role;Signal Pathway;Signal Transduction;Signaling Protein;Site;small molecule;Synapses;T cell infiltration;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Tamoxifen;Therapeutic;Time;tool;Transgenic Mice;Transgenic Organisms;Translating;Transplantation;tumor;Tumor Antigens;tumor growth;Tumor-Infiltrating Lymphocytes;V(D)J Recombination;Vertebrates;Work

PROJECT_TITLE: DNA-PKcs Regulation of LAT-Mediated Early TCR Signaling in CD4+ and CD8+ T Cells

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Social Determinants of Health

PHR: Project Narrative Heart failure (HF) is an urgent public health priority whose incidence and prevalence increase non-linearly with age. By investigating factors underlying cardiac resilience in late life, this proposal will address critical challenges enumerated in the NHLBI Strategic Vision regarding pathobiologic mechanisms of HFpEF onset, factors underlying resilience to HLBS disease, and integration of multidimensional data to identify biologically distinct subgroups of cardiovascular aging. The results will identify health behaviors, social drivers, and biologic pathways promoting late-life cardiac resilience to inform future interventions to prevent HF, and thereby decrease HF-associated morbidity and mortality.

PI_NAMEs: SHAH, AMIL M (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Acceleration;Activities of Daily Living;Address;Affect;Age;age related;Age Years;Aging;aptamer;Atherosclerosis Risk in Communities;Attention;Behavior;Biological;biracial;Cardiac;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cell Aging;circulating biomarkers;Communities;comorbidity;Data;Databases;Dementia;Development;Diet;Disease;Echocardiography;Education;effective intervention;Elderly;Exercise;experience;Exposure to;frailty;Freedom;Functional disorder;functional outcomes;Future;Genetic;Genetic Variation;genome sequencing;genomic data;Genomics;Goals;Health behavior;Heart failure;heart function;heart imaging;heart preservation;high risk;Impairment;Incidence;Income;Individual;innovation;Intervention;Intervention Studies;late life;Left Ventricular Ejection Fraction;lifestyle factors;lung pressure;Measurement;Measures;Mediating;mild cognitive impairment;Modeling;modifiable behavior;Molecular;Molecular Target;Morbidity - disease rate;mortality;multidimensional data;Myocardial dysfunction;National Heart, Lung, and Blood Institute;Neighborhoods;Neurocognitive;novel;older adult;Outcome;Participant;Pathway interactions;Persons;phenotypic data;Physical activity;Physical Function;Plasma;preservation;Prevalence;prevent;Prevention;protein biomarkers;Proteins;Proteomics;public health priorities;Race;Research;Research Proposals;resilience;Resources;Risk Behaviors;Risk Factors;Role;Sampling;senescence associated secretory phenotype;social;social adversity;Strategic vision;structural determinants;Subgroup;Symptoms;Visit;whole genome

PROJECT_TITLE: Late-life trajectories of cardiac function to define pathways of cardiac resilience

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ORG_CITY: STANFORD

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative: Our program aims to build a molecular and optical cell atlas of the human inner ear as a resource for the scientific community to accelerate progress in discovering effective therapies for auditory and vestibular disorders. To achieve this objective, we will apply the latest molecular and optical imaging tools to live human inner ear tissues from organ donors, vestibular schwannoma patients, and rapid autopsy participants. We will also raise awareness of human inner ear research and enhance opportunities for collaboration by making our data and tissues widely available, by providing technical instruction, and by outreach activities.

PI_NAMEs: CHENG, ALAN GI-LUN (contact);STANKOVIC, KONSTANTINA M

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: 3-Dimensional;Acceleration;Acoustic Neuroma;Address;Adult;Animal Model;Animals;Architecture;Archives;Artificial Intelligence;Atlases;Auditory;Auditory system;Autopsy;Awareness;Biological Response Modifier Therapy;Cadaver;Cataloging;Cells;cellular imaging;Cellular Morphology;Cochlea;Collaborations;Communities;Crista ampullaris;Cryoultramicrotomy;Data;Data Analyses;data sharing;Databases;deafness;design;Disease;Dissociation;Doctor of Philosophy;doctoral student;Ear;Educational Materials;Educational workshop;effective therapy;Epithelium;equilibration disorder;Equilibrium;Event;Excision;Faculty;Fetal Tissues;flexibility;Gene Expression;Genes;Hearing;hearing impairment;Hearing problem;high resolution imaging;Histologic;Histology;Hour;Human;human imaging;Image;Imaging Device;imaging probe;imaging system;Imaging Techniques;Immunohistochemistry;In Situ Hybridization;inner ear diseases;insight;Instruction;International;Investigation;Knowledge;Labyrinth;Linear Regressions;Maps;Medical;Medical Records;Medical Students;meetings;Messenger RNA;Methods;microendoscopy;Molecular;molecular imaging;Molecular Profiling;Morphology;novel;Operative Surgical Procedures;Optical Coherence Tomography;optical imaging;Optics;Organ;Organ Donor;Organ Procurements;Outcome;outreach;Oval Window;Participant;Patients;Perilymph;Persons;pharmacologic;Physiological;Postdoctoral Fellow;Process;programs;Proteins;Protocols documentation;Publications;Publishing;Recording of previous events;recruit;Registries;Research;Research Personnel;Resolution;Resources;round window;Saccule structure;Scanning Electron Microscopy;Science;Scientist;Sensory;single-cell RNA sequencing;social media;Specimen;State Medicine;success;Techniques;Temporal bone structure;Testing;Therapeutic;tissue archive;Tissue Banks;Tissue Donors;Tissues;tool;Training;Training Technics;Transcript;transcriptome;Translations;Utricle structure;Validation;validation studies;Vestibular Diseases;Vestibular function;vestibular system;Vestibule;virtual;virtual experiments;virtual surgery

PROJECT_TITLE: Human Ear Cellular Atlas


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Prevention;Urologic Diseases

PHR: PROJECT NARRATIVE Calcium phosphate kidney stones are increasing in prevalence, highly recurrent, and have no established medical preventive therapy. This proposal combines in vivo studies examining calcium phosphate crystal growth (a necessary precursor for calcium phosphate stone formation), short-term metabolic studies in calcium phosphate stone formers, and long-term studies in a rat model of calcium phosphate stone disease to test whether hydroxycitrate, a molecule closely related to citrate, can reduce calcium phosphate stone recurrence.

PI_NAMEs: MAALOUF, NAIM M (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Address;Alkalies;Animal Model;Atomic Force Microscopy;Biochemical;Biochemistry;Body Weight decreased;calcification;Calcium;Calcium Oxalate;calcium phosphate;calcium phosphate precipitation;Caring;Chemicals;Chemistry;Citrates;Clinical;Clinical Trials;clinically relevant;comparative effectiveness;Crystal Formation;Crystallization;Data;Deposition;Development;Disease;Dose;Environment;Excretory function;experience;experimental study;Foundations;Future;Growth;Human;hypercalciuria;In Vitro;in vivo;Incidence;Ingestion;inhibitor;innovation;interstitial;Intervention;Ionic Strengths;Kidney;Kidney Calculi;Kinetics;Length;Longitudinal Studies;Measurement;Medical;Metabolic;metabolic abnormality assessment;Methods;Microfluidic Microchips;Microscopic;Modeling;Molecular;Nephrolithiasis;novel;novel therapeutics;Operative Surgical Procedures;Oral;Outcome;Participant;potassium citrate;Prevalence;prevent;Prevention;Preventive therapy;prophylactic;Prophylactic treatment;Rattus;Recurrence;Regimen;Renal Tissue;Repeat Surgery;Research;Resolution;Risk;Risk Reduction;Rodent;Rodent Model;Role;Solubility;spatiotemporal;Specimen;Surface;System;Techniques;Testing;Therapeutic;thiazide;Treatment Efficacy;urinary;Urinary Calculi;Urine;urolithiasis;Weight-Loss Drugs

PROJECT_TITLE: Hydroxycitrate: A Novel Therapy for Calcium Phosphate Urinary Stones

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(05)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Hearing Loss;Infectious Diseases;Neurosciences;Patient Safety;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE ORC-13661 is novel, first in class, orally bioavailable drug developed to prevent the tragic side effect of hearing loss in patients being treated with parenteral aminoglycoside antibiotics. Preventing this side effect not only benefits patients who might be treated with aminoglycoside today, also makes these effective antibiotics a better choice for thousands of additional patients. The proposed multicenter clinical trial will evaluate the effectiveness of ORC-13661 for protecting the hearing of patients with severe non-tuberulous Mycobacteria infections requiring prolonged chronic treatment with IV amikacin.

PI_NAMEs: RUBEL, EDWIN W;WINTHROP, KEVIN LORING (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Adult;Adult women;Adverse event;Aftercare;Air;Amikacin;Aminoglycoside Antibiotics;aminoglycoside-induced ototoxicity;Aminoglycosides;Animal Model;Antibiotic Therapy;Antibiotics;Auditory Threshold;awake;Azithromycin;bactericide;Biological Availability;bone;Bronchiectasis;Canis familiaris;Chronic;Chronic Disease;chronic infection;Clarithromycin;Clinical;clinically relevant;Cochlea;Communicable Diseases;Control Animal;Data Reporting;design;Deterioration;Diagnosis;Disease;Disease Progression;Dose;Double-Blind Method;Drug Exposure;Drug Kinetics;effective therapy;effectiveness evaluation;efficacy evaluation;efficacy study;Electrocardiogram;Equilibrium;Equipment and supply inventories;Evaluation;experimental study;Exposure to;FDA approved;Frequencies;Genus Mycobacterium;Goals;Gram-Negative Bacteria;Guidelines;Hair Cells;Half-Life;Health;healthy volunteer;Hearing;hearing impairment;Hearing Protection;Human Volunteers;In Vitro;in vivo;indexing;Intravenous;intravenous administration;Laboratories;Laboratory Finding;Legal patent;Life;Lung;Measurable;Measures;men;Metabolic;Multi-Institutional Clinical Trial;Mus;Mycobacterium Infections;Neonatal;neonatal mice;new chemical entity;non-tuberculosis mycobacteria;non-tuberculous mycobacterial infection;novel;novel therapeutics;older adult;Oral;Oral Administration;Organ of Corti;ototoxicity;overtreatment;parenteral administration;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;phase 1 testing;phase 2 study;Placebo Control;Plasma;pre-clinical;prevent;prevent hearing loss;Prevention;primary endpoint;programs;Publishing;Quality of life;Randomized;Rattus;Recommendation;Research;response;Rifampin;Safety;safety study;secondary endpoint;Sensorineural Hearing Loss;Sensory Hair;Serious Adverse Event;side effect;small molecule;speech in noise;Swimming;Symptoms;Testing;Therapeutic Index;Time;Tinnitus;tool;Toxic effect;Toxicology;treatment duration;Treatment Protocols;United States;Universities;Vertigo;Washington;Work;Zebrafish

PROJECT_TITLE: Phase 2 Study of the Efficacy and Safety of ORC-13661 for the Prevention of Ototoxicity in Patients Receiving Intravenous Amikacin for Treatment of Non-Tuberculous Mycobacterium Infection


NIH_SPENDING_CATS: Cancer;Cardiovascular;Clinical Research;Heart Disease;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative: Bruton’s tyrosine kinase inhibitors (BTKIs) are an orally administered class of drug linked with dramatically improved survival for many blood-based cancers; however, BTKIs are associated with a high-risk of serious or fatal cardiac arrhythmias. Currently, little is known regarding what drives these cardiotoxic events, or who will develop them. This multidisciplinary proposal seeks to determine whether BTKIs lead to immune-induced adverse cardiac remodeling and arrhythmia vulnerability by using novel cardiac imaging and immunogenomic profiling techniques, while providing insights in the therapeutically targetable pathways involved.

PI_NAMEs: ADDISON, DANIEL  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Address;Adult;Affect;Agammaglobulinaemia tyrosine kinase;Age;American;animal data;Animal Model;Animals;Aorta;Arrhythmia;Atrial Fibrillation;Automobile Driving;Blood;Blood Pressure;Blood Vessels;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;Cardiotoxicity;cardiovascular effects;Cardiovascular system;Cells;Chronic Lymphocytic Leukemia;Clinical;cohort;Data;Development;effective therapy;EFRAC;Electrocardiogram;Event;Expectancy;Fibrosis;Gender;Heart Atrium;heart imaging;Hematologic Neoplasms;high risk;Holter Electrocardiography;Human;Hypertension;IL17 gene;IL8 gene;Immune;immune activation;Immune response;Immunogenomics;Immunologic Techniques;improved;improved outcome;Incidence;indexing;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;inhibitor therapy;Innate Immune Response;insight;Interleukin-1;Interleukin-6;Intervention;kinase inhibitor;Lead;Left;Link;Malignant Neoplasms;Measures;Mediating;Mediator;Methods;Modeling;Monitor;monocyte;mortality;mouse model;multidisciplinary;novel;Ohio;Oncology;oncology program;Oral;Oral Administration;Pathway interactions;patient biomarkers;Patients;Pharmaceutical Preparations;Phenotype;Play;Population;pre-clinical;preclinical study;Prediction of Response to Therapy;Predisposing Factor;primary endpoint;prospective;Prospective Studies;prospective test;recruit;Resources;response;Risk;Risk Factors;Role;single cell genomics;success;Techniques;Testing;Therapeutically Targetable;Time;Toxic effect;Tyrosine Kinase Inhibitor;Up-Regulation;Ventricular

PROJECT_TITLE: Novel patient biomarkers and mechanisms of TKI associated Cardiotoxicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-Q(02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Nutrition;Obesity;Patient Safety;Pediatric;Prevention;Primary Health Care

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Obesity, heart disease, and diabetes risks begin very early in life, and finding new ways to promote healthy growth can be of large benefit to public health by reducing the number of children who are already obese and at risk for poor health. This research explores factors related to obesity that are present in infancy, and how these factors can be used to better understand a child’s risk for obesity. The research tests new ways to predict obesity and designs tools for clinicians to assess a child’s obesity risk in real-time and provide guidance on healthy growth.

PI_NAMEs: WOOD, CHARLES T (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 2 year old;3 year old;Active Learning;Address;Adolescent;Award;Behavioral;Bioinformatics;Biometry;Body mass index;Cardiometabolic Disease;cardiometabolic risk;career;career development;Cessation of life;Characteristics;Child;Child Health;Childhood;Clinical;clinical decision support;clinical implementation;clinical predictive model;Clinical Research;Clinical Trials;clinically relevant;comparative;Consultations;Consumption;cost;Data;data harmonization;Data Linkages;Data Science;Data Set;design;Development Plans;diabetes risk;early childhood;Electronic Health Record;Endowment;Enrollment;Ensure;Environment;Epidemiologist;Epidemiology;experience;feeding;Food;Goals;Growth;Health;Health Sciences;Health Services Research;Healthcare;heart disease risk;high risk;implementation evaluation;implementation science;improved;Individual;infancy;Infant;insight;Intervention;Intervention Trial;Learning;Length;Life;Life Cycle Stages;longitudinal analysis;Measurement;Measures;Medical center;Mentors;Mentorship;Modeling;modifiable risk;Morbidity - disease rate;novel;Obesity;obesity in children;obesity prevention;obesity risk;obesity treatment;Outcome;Outcomes Research;Overweight;Parents;Patients;Pattern;Pediatric Hospitals;Pediatrics;population health;predictive modeling;predictive tools;premature;Prevalence;prevent;Prevention strategy;Prevention trial;preventive intervention;Primary Care;primary care clinician;primary care setting;primary care visit;Primary Prevention;professor;prognostic model;programs;prospective;Provider;Public Health;rapid infant weight gain;Research;research and development;Research Institute;Research Personnel;Research Proposals;Resources;Risk;Risk Factors;risk prediction;risk prediction model;Series;Site;skills;Source;statistics;success;support tools;Testing;Time;tool;Training;Translations;Universities;Validation;Weight;wellness visit;Wood material;Work

PROJECT_TITLE: POWER: Predicting Obesity with Enhanced EHR Resources

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Disability Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE This study proposes to use newly available databases and methods to monitor the health of adolescents and young adults with intellectual or developmental disabilities; it will also examine the circumstances under which transitions from pediatric to adult-oriented health care promote or impede the health of this population.

PI_NAMEs: CHIEN, ALYNA TUNG-MEI (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent and Young Adult;adolescent health;adolescent health outcomes;Adult;Adult Children;Age;age related;aged;Algorithms;associated symptom;Cardiovascular Diseases;care outcomes;Caring;Characteristics;Child;Childhood;childhood cancer survivor;Chronic Disease;Clinical;clinical care;Colorado;comorbidity;Data;Data Set;Databases;demographics;Developmental Disabilities;Disabilities experience;disability;Disabled Children;Disabled Persons;Disease Management;Eligibility Determination;Emergency medical service;Emergency Situation;Excess Mortality;experience;Health;health care quality;Healthcare;Healthcare promotion;Healthcare Systems;Hospitals;improved;in vivo;Individual;inpatient service;Inpatients;Insurance;Insurance Carriers;Insurance Coverage;Intellectual functioning disability;interest;Intervention;Life;Life Expectancy;life span;longitudinal dataset;Massachusetts;Measures;Medicaid;Medicaid eligibility;Methods;Monitor;Morbidity - disease rate;Movement;National Institute of Child Health and Human Development;New York;novel;Nurses;Outcome;Patients;payment;Persons;physical impairment;Physicians;Play;Policies;Population;population health;profession allied to medicine;Quality of Care;Quality of life;Quasi-experiment;Recommendation;Research;Role;screening;service utilization;Services;System;Testing;Time;tool;Validation;young adult;Youth

PROJECT_TITLE: Healthcare Transitions and the Health of Adolescents and Young Adults with Intellectual or Developmental Disabilities

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The proposed research is relevant to NIH because it is a science oriented proposal that has strong translational potential. The proposal will identify novel mechanistic pathophysiology during heart failure development and progression in a large animal model close to human physiology. The study will also provide critical preclinical data on the therapeutic efficacy of a novel gene therapy for heart failure which represents a potential major advance in treating patients with failing hearts.

PI_NAMEs: HONG, TINGTING ;SHAW, ROBIN M (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Affect;Animal Model;Animals;Architecture;Biochemical;biochemical tools;Biological;Biological Markers;Blood;Calcium;Calcium Signaling;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cells;Chronic;Clinical Trials;Congestive Heart Failure;Data;Dependovirus;Deterioration;Development;Dilated Cardiomyopathy;Dose;Echocardiography;efficacy study;EFRAC;Electron Microscopy;Epidemic;Evaluation;Excision;Failure;Functional disorder;gene therapy;gene-targeted therapy;Goals;Government;Heart;Heart failure;heart function;heart preservation;hemodynamics;Human;Image;Imaging Device;Impairment;improved;in vivo;Injections;innovation;intravenous injection;L-Type Calcium Channels;Left Ventricular Ejection Fraction;Left Ventricular Function;Link;Medical;Membrane;Membrane Microdomains;Methods;Microanatomy;microscopic imaging;Miniature Swine;Modeling;Monitor;Morbidity - disease rate;mortality;Mus;Muscle;Muscle Cells;Myocardial;Myocardial dysfunction;Myocardium;novel;Organelles;Outcome;Pathologic;Pathway interactions;Patients;Persons;Physiology;pre-clinical;Proteins;reconstitution;Recovery;reduce symptoms;Relaxation;Research;restoration;Rodent;Rodent Model;Role;Ryanodine Receptor Calcium Release Channel;Satellite Viruses;Science;SERCA2a;Stress;Symptoms;Syndrome;Tachycardia;Testing;Text;Therapeutic;therapeutic target;Translating;translational potential;Treatment Efficacy;United States;United States National Institutes of Health;Ventricular;Ventricular Remodeling;Work

PROJECT_TITLE: Correcting Cardiac Microdomains Reverses Non-Ischemic Cardiomyopathy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: BERKELEY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project narrative Understanding differences between human populations at the level of individual cells has the po- tential to improve our understanding of human health, with direct applications in the areas of diagnosis and therapeutics. While the exploration of human variability at the single-cell level is rapidly advancing, the corresponding statistical methodology to analyze this data when collected from a heterogeneous human population lags behind. This project will create a coherent statistical framework for determining the effect of single-cell variability on patient health; the methods will be implemented in open-source software that researchers can use in their studies to ﬁnd predictors of human health outcomes at the single-cell level.

PI_NAMEs: PURDOM, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;advanced disease;analytical tool;Area;bioinformatics pipeline;Biological;biological systems;biomarker identification;cell type;Cells;Complement;Computer software;Computing Methodologies;Data;Data Analyses;Data Reporting;Detection;Development;Diagnosis;direct application;Disease;disease classification;disease diagnosis;Eating;Evaluation;Foundations;Future;Genes;Goals;Health;Heterozygote;Human;human disease;improved;Individual;individual patient;insight;Mathematics;Measurement;method development;Methodology;Methods;Modeling;mRNA Expression;novel;novel marker;open source;Outcome;Output;Partner in relationship;patient biomarkers;patient population;patient variability;Patient-Focused Outcomes;Patients;Phenotype;Population;Population Study;potential biomarker;predictive modeling;Prevention;Probability;Procedures;programs;Research;Research Personnel;Role;single cell mRNA sequencing;single cell sequencing;single-cell RNA sequencing;Statistical Methods;Stream;Techniques;Testing;Therapeutic;tool;Tweens;Variant;Visualization software;Work

PROJECT_TITLE: A statistical framework for disease classification with scRNA-Seq data

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TEMPE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative To reduce the substantial health disparities in childhood obesity (a major focus of the public health agenda in the U.S.) among low-income ethnic minority groups, we must understand social, cultural, behavioral, and biological influences on the course of weight gain from the prenatal period through infancy and childhood. A central goal of this project is to evaluate trajectories of weight gain and cardiometabolic health over time among low-income Mexican American youth and identify the reasons children divert from a healthy pattern of weight gain. An understanding of risk and protective influences on the health of at-risk youth will maximize the effectiveness of targeted prevention efforts and inform public health policy.

PI_NAMEs: LUECKEN, LINDA J;PEREZ, MARISOL  (contact)

PROGRAM_OFFICER_NAME: ROUSSOS, GINA PATIENCE

PROJECT_TERMS: 10 year old;19 year old;5 year old;Acculturation;Acute;Address;Adolescence;Affect;Age;Behavioral;Biological;Birth;Blood Pressure;Body mass index;C-reactive protein;cardiometabolic risk;cardiometabolism;cardiovascular health;Cardiovascular system;Characteristics;Child;Child Mental Health;Childhood;Cholesterol;Chronic;Classification;Climate;Communities;Country;COVID-19;COVID-19 impact;COVID-19 pandemic;critical period;cultural values;Data;Data Collection;Development;Diabetes Mellitus;Disadvantaged;Discrimination;Disease;Eating Behavior;Economics;Effectiveness;Environmental Risk Factor;ethnic minority population;ethnic minority status;Ethnic Origin;Ethnic Population;Event;experience;Exposure to;Family;feeding;Funding;General Population;Glycosylated hemoglobin A;Goals;Growth;Health;health difference;health disparity;health equity;health goals;health inequalities;Health Policy;Health Status;Heart Diseases;high risk;high risk population;Hispanic;Hispanic Americans;Hispanic Populations;infancy;Infant;Interleukin-6;Latino;Life;life span;longitudinal dataset;Longitudinal Studies;Low income;Measures;Medical Records;Mental Health;Mexican Americans;middle childhood;Morbidity - disease rate;mortality;Mothers;Neighborhoods;Not Hispanic or Latino;Obesity;obesity development;obesity in children;obesity prevention;obesity risk;Overweight;pandemic disease;Parents;Participant;Pathway interactions;Pattern;physical conditioning;Policies;Poverty;prenatal;Prevention;Preventive;Process;prospective;protective factors;Protocols documentation;Puberty;Public Health;public health intervention;Race;racial population;Reporting;Research;resilience;resilience factor;Risk;Risk Factors;Sampling;Shapes;social;social culture;social group;statistics;Stress;stressor;Surveys;System;Time;United States National Institutes of Health;Weight;Weight Gain;World Health Organization;Youth

PROJECT_TITLE: Childhood Obesity and Cardiometabolic Health among Impoverished Mexican Americans

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE In cystic fibrosis (CF), a life-limiting lung disease caused by mutations in the CFTR gene, recently FDA-approved therapies still only partially restore the basic defect for some mutations, while other genotypes have no available intervention. We have discovered that small non- coding nucleotide sequences called microRNA are targetable inhibitors of CFTR restoration, applicable across mutation and therapeutic approach. In the proposed experiments, we will test whether antisense oligonucleotide (ASO) steric blockade of miR-145 binding to CFTR selectively improves the effectiveness of current FDA-approved and future investigational CFTR-directed therapies to improve the pulmonary health and quality of life for all patients with the disease.

PI_NAMEs: HARRIS, WILLIAM THOMAS (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: 3' Untranslated Regions;Affect;airway epithelium;airway surface liquid;Animal Model;antagonist;Antisense Oligonucleotides;autosome;Base Sequence;Binding;Binding Sites;Caring;Caucasians;Cell Line;Cells;Child;Chlorides;Clinical;Clinical Research;Complex;CRISPR/Cas technology;Cystic Fibrosis;cystic fibrosis airway epithelia;cystic fibrosis patients;Data;Defect;Delta F508 mutation;Disease;Disease Progression;effective intervention;effective therapy;Effectiveness;efficacy testing;Epithelial Cells;Epithelium;Exons;experience;experimental study;FDA approved;Future;Gene Expression;Genes;Genetic;Genotype;genotyped patients;Health;Hereditary Disease;Human;improved;in silico;in vivo;in vivo evaluation;Individual;inhibitor;innovation;Interruption;Intervention;Length;Life;Lung Diseases;lung health;Measurement;Measures;Mediating;Messenger RNA;MicroRNAs;Modeling;monolayer;Mucociliary Clearance;Mucous body substance;mutant;Mutation;next generation;Nonsense Mutation;Nonsense-Mediated Decay;Nose;novel;novel strategies;Nucleotides;oligonucleotide delivery;Optical Coherence Tomography;Organoids;Participant;Pathway Analysis;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phenotype;Population;premature;preservation;protein expression;Proteins;pulmonary function;Quality of life;Rattus;Regulator Genes;response;restoration;Sampling;screening;side effect;Site;Specimen;Swelling;Techniques;Terminator Codon;Testing;Therapeutic;Transcript;transcriptome sequencing;Transfer RNA;Transforming Growth Factor beta;Translating;Translations;Untranslated RNA;VX-770

PROJECT_TITLE: miR-145 target site blockade is a selective strategy to enhance CFTR restoration and readthrough

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: HOUSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: TEXAS SOUTHERN UNIVERSITY

PHR: PROJECT NARRATIVE The Center for Biomedical and Minority Health Research (CBMHR) at Texas Southern University (TSU) aims to support basic biomedical research for diseases that disproportionately impact underrepresented minority (URM) populations and lead to burdensome morbidity and mortality among this community. The CBMHR proposes to propel studies of these diseases by providing facilities, equipment, and expertise for research studies, career enhancement programs to develop early stage investigators into thriving biomedical scientists able to secure funding for URM health research, as well as strategic community partnerships that bridge URMs with healthcare services and research throughout the Greater Houston Community.

PI_NAMEs: LIANG, DONG ;OLALEYE, OMONIKE ARIKE (contact);XIE, HUAN

PROGRAM_OFFICER_NAME: GARRIDO, CARLOS OSWALDO

PROJECT_TERMS: Address;Affect;African American population;Animal Model;Applications Grants;Award;Basic Science;Biomedical Research;biomedical scientist;career;career development;Collaborations;collaborative environment;Communicable Diseases;Communities;community engaged approach;community engagement;community organizations;community partnership;COVID-19 impact;data acquisition;design;Development;Disease;disease disparity;disparity gap;education research;Environment;Equipment;Evaluation;Extramural Activities;Faculty;faculty research;Fostering;Foundations;Funding;Goals;Grant;Health;health care service;health disparity;Health Personnel;high reward;Historically Black Colleges and Universities;improve minority health;improved;Infrastructure;innovation;Institution;instrument;instrumentation;Language;Legal patent;Malignant Neoplasms;Mentors;Mentorship;Methodology;minority communities;Minority Groups;minority health;Minority Health Research;Mission;Modality;Monitor;Morbidity - disease rate;mortality;novel;Outcome;outreach;Paper;Pilot Projects;Postdoctoral Fellow;Productivity;programs;Publications;Publishing;Recommendation;Recording of previous events;Research;Research Design;research facility;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;research study;Research Support;Scientific Inquiry;Secure;Services;Students;success;synergism;Teacher Professional Development;Texas;Training Programs;Underrepresented Minority;United States National Institutes of Health;Universities;urban setting;Writing


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: LIANG, DONG  (contact)

PROJECT_TERMS: Accountability;Address;Administrator;Advisory Committees;anti-cancer research;Anti-HIV Agents;Area;Award;Back;Biomedical Research;cancer prevention;career;career development;Cities;Classification;Collaborations;collaborative environment;college;Communication;Communities;community engagement;conflict resolution;Consultations;Development;Drug Interactions;Drug Kinetics;Education;Educational workshop;Ensure;Environment;ethnic diversity;Evaluation;experience;Extramural Activities;Faculty;faculty mentor;Fostering;Funding;Future Generations;Geographic Locations;Grant;Health;health disparity;health equity;Health Professional;higher education;Historically Black Colleges and Universities;improved;Infrastructure;infrastructure development;innovation;Institution;International;Journals;Leadership;Legal patent;Logistics;Mainstreaming;Medical center;Medicine;meetings;member;Mentors;Mentorship;Methodological Studies;minority children;minority communities;minority health;Minority Health Research;minority investigator;Minority-Serving Institution;Monitor;multidisciplinary;National Institute of Allergy and Infectious Disease;novel;Outcome;Peer Review;Persons;Pharmaceutical Preparations;Phase I Clinical Trials;Pilot Projects;Postdoctoral Fellow;Preclinical Drug Development;Procedures;Process;Productivity;Program Development;Program Reviews;programs;Progress Reports;Publications;Recommendation;Recording of previous events;recruit;Research;Research Activity;Research Design;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Scientist;senior faculty;Series;Structure;Students;success;symposium;synergism;Talents;Teacher Professional Development;Texas;Training;Underrepresented Minority;underserved community;United States National Institutes of Health;Universities;Vocational Guidance;ward;Writing

PROJECT_TITLE: CBMHR Administrative Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: GAO, SONG  (contact)

PROJECT_TERMS: Acceleration;Address;androgen independent prostate cancer;animal care;Animals;anti-cancer research;antimicrobial;Applications Grants;Area;Award;Bioinformatics;Biological Products;Biomedical Research;Biometry;cancer prevention;career;chemotherapeutic agent;Clinical Sciences;Collaborations;community engaged approach;Core Facility;data management;Development;drug candidate;drug development;drug metabolism;Educational workshop;Environment;environmental toxicology;Equipment;Evaluation;Event;Faculty;faculty research;falls;Fees;Formulation;Funding;genetic analysis;genome editing;Grant;gulf coast;Health care facility;Human Resources;improved;Infrastructure;innovation;Institution;instrument;inter-institutional;Interdisciplinary Study;International;Intervention;Laboratories;Lead;lead optimization;Legal patent;Link;member;Methionine;Methodology;minority health;Minority Health Research;Molecular;Molecular and Cellular Biology;Molecular Biology;new therapeutic target;novel;Peer Review;Peptide Hydrolases;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacy facility;Pilot Projects;pre-clinical;preclinical development;Productivity;programs;Publishing;recruit;Reproducibility;Research;Research Design;research faculty;Research Infrastructure;Research Institute;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Reverse Transcriptase Polymerase Chain Reaction;Services;skills;Structure;symposium;synergism;Techniques;Texas;Toxic effect;Training;Training Programs;Translational Research;Translations;Underrepresented Minority;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Research Infrastructure Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Patient Safety

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE The overall goal of the University of Chicago K12 program in Oncology is to provide a distinct pathway of training, producing the next generation of highly skilled academic Oncologists who are capable of designing and administering hypothesis-driven pilot/Phase I, Phase II and Phase III cancer therapeutic trials on a global scale. Leveraging resources across the University, the Paul Calabresi K12 Scholars Program is our highly mentored, didactic coursework-intensive program, and “hands on” clinical research training which results in a Master of Science in Clinical Investigation. The strength of our clinical programs coupled with our research intensity and our focus on genetics/genomics and experimental therapeutics makes the University of Chicago an ideal institution for the preparation of a clinical oncology workforce for the era of precision medicine in Oncology.

PI_NAMEs: OLOPADE, OLUFUNMILAYO F. (contact);SMITH, SONALI

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Advisory Committees;Appointment;Award;cancer clinical trial;cancer genomics;career;Chicago;Clinical;Clinical Informatics;clinical investigation;Clinical Oncology;Clinical Pharmacology;Clinical Research;Clinical Trials;Clinical Trials Network;Communities;Comprehensive Cancer Center;Country;Data Science;design;Doctor of Medicine;Doctor of Pharmacy;Doctor of Philosophy;Education;Elements;Entrepreneurship;Environment;Faculty;flexibility;Funding;Genomics;Goals;Immunology;Immunotherapy;innovation;Institution;K-Series Research Career Programs;Master of Science;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;microbiome research;mid-career faculty;Minority Groups;Nurses;Oncology;Paper;patient oriented research;Peer Review;Pharmacogenomics;Phase;phase III trial;Postdoctoral Fellow;Principal Investigator;Productivity;programs;Protocols documentation;Publishing;Qualifying;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Scholars Program;skills;Structure;Teacher Professional Development;Testing;Therapeutic Research;Training;training opportunity;Training Programs;Translational Research;underserved minority;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Developing an Oncology Workforce for the 21st Century

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Urologic Diseases

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: NARRATIVE Poor response to chemotherapy poses a major obstacle for muscle-invasive bladder cancer patients, since chemotherapy only generates a dismal 5% improvement in overall survival. The success of chemotherapy not only results from its direct cytotoxic effects on tumor cells but also depends on 1) a “wound response” of cancer stem cells to repopulate tumors and 2) an effective anti-tumoral immune response. Our proposal will investigate the above two understudied phenomena, with the long-term goal to exploit these processes for therapeutic targeting.

PI_NAMEs: CHAN, KEITH SYSON  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Address;Adjuvant Therapy;antagonist;anti-tumor immune response;Attenuated;Automobile Driving;Biology;Bladder Neoplasm;cancer cell;Cancer Model;Cancer Patient;cancer prevention;cancer stem cell;cancer survival;cancer therapy;cancer type;CASP1 gene;cell injury;Cells;Cessation of life;Chemoresistance;chemotherapy;Clinical;clinical translation;cytotoxic;Dinoprostone;DNA;Drug Targeting;druggable target;ds-DNA;Epithelium;extracellular;Extravasation;FDA approved;Funding;Genetic;Goals;HMGB1 gene;Immune;Immune response;Immuno-Chemotherapy;Immunosuppression;improved;in vivo;Inflammasome;inhibitor;innovation;insight;Interleukin-1 beta;Intervention Studies;Knock-out;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Molecular;Mus;muscle invasive bladder cancer;Myelogenous;Myeloid-derived suppressor cells;Nature;neoplastic cell;novel strategies;Pathway interactions;patient response;Patients;Peptide Hydrolases;Pharmaceutical Preparations;pharmacologic;Population;prevent;Process;programs;Proliferating;protein complex;PTGS2 gene;Publishing;receptor;Regulation;Reporting;Research;Research Project Grants;Residual Neoplasm;response;Rest;sensor;Signal Pathway;Signal Transduction;stem cells;success;synergism;T-Lymphocyte;Testing;therapeutic target;therapeutically effective;TLR4 gene;Transcription Repressor;Treatment Efficacy;treatment response;tumor;tumor microenvironment;tumor xenograft;tumor-immune system interactions;United States;Up-Regulation;WFDC2 gene;wound;wound response

PROJECT_TITLE: Targeting tumor repopulation and the immune microenvironment to overcome chemoresistance

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


PI_NAMEs: POON, IVY CHUI (contact)

PROJECT_TERMS: Adherence;Advertisements;Advisory Committees;Affect;African American population;Applications Grants;Area;Award;Behavioral;Behavioral Sciences;Biomedical Research;Cardiovascular Diseases;career development;Clinical;Clinical Sciences;Collaborations;college;Committee Members;Communities;community engagement;Community Networks;Competence;Core Facility;COVID-19;Data;design;Development;Development Plans;Disease;Doctor's Degree;Educational workshop;Effectiveness;Electronic Mail;Eligibility Determination;Engineering;Equipment;Evaluation;Extramural Activities;Faculty;Feedback;Funding;Future;Goals;Government;Grant;gulf coast;Health Disparities Research;Health Sciences;Hispanic Americans;HIV/AIDS;improved;Individual;Institution;interest;Leadership;Malignant Neoplasms;Mathematics;Measures;Medical center;meetings;Mentors;Mentorship;Minority Groups;Minority Health Research;minority scientist;Modification;Native Americans;novel;Participant;Performance;Pharmacy facility;Pilot Projects;Population;Positioning Attribute;Postdoctoral Fellow;preference;Preparation;Productivity;professor;Program Development;Program Effectiveness;Program Evaluation;programs;recruit;Reduce health disparities;Reporting;Request for Applications;Research;Research Activity;Research Infrastructure;Research Personnel;Research Proposals;Resources;Science;Scientist;Senior Scientist;Series;Services;skills;success;symposium;synergism;Technology;Texas;Time;Training;Travel;Underrepresented Minority;United States National Institutes of Health;Universities;web site;webinar;Writing

PROJECT_TITLE: Investigator Development Core


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: PITTSBURGH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The Training in Diversity education program, or TiDe, will transform rehabilitation research culture by educating rehabilitation clinician scientists in the skills and knowledge needed to train and support the next generation of underrepresented clinician scientists with the capacity to advance rehabilitation research.

PI_NAMEs: HICKS, GREGORY E;SKIDMORE, ELIZABETH RENEE (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: academic program;Address;Agreement;American;American Physical Therapy Association;Boston;career;Climate;cohort;Collaborations;combat;Communities;community partners;Delaware;demographics;Development;Discipline;Doctor's Degree;Education;education cost;Educational workshop;Ensure;Environment;Equity;Ethnic Origin;experience;Extramural Activities;Faculty;Financial Support;Foundations;Funding;Future;Generations;hands on research;Health Sciences;Human Resources;Institution;Investments;Knowledge;Laboratory Research;Learning;Learning Skill;matriculation;meetings;Mentorship;next generation;Occupational Therapy;Outcome;Participant;Pathway interactions;Phase;Physical therapy;Professional Organizations;professional students;Program Sustainability;programs;Race;recruit;rehabilitation research;Rehabilitation therapy;Research;Research Support;Research Training;Resources;Risk;Science;scientific organization;Scientist;Series;skills;Societies;socioeconomic diversity;Students;Talents;Therapeutic Studies;Time;Trainers Training;Training;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Washington;webinar

PROJECT_TITLE: Turning the TiDe: Training Diverse Clinician Scientists in Rehabilitation Research

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: AJEWOLE, VERONICA B. (contact)

PROJECT_TERMS: Access to Information;Address;Affect;African American;African American population;Appointment;Appointments and Schedules;Asian;Awareness;barrier to care;Biomedical Research;Black race;Charities;Chronic Disease;Clinic;Clinical Research;Clinical Trials;Collaborations;college;Communication;Communities;community center;community collaboration;community engagement;Community Health;Community Healthcare;community organizations;community partners;Community Services;Complex;County;Databases;Development;Diabetes Mellitus;disparity gap;Dyslipidemias;Education;education research;Ensure;ethnic diversity;Ethnic Origin;Event;Faculty;Federally Qualified Health Center;Feedback;Financial Support;Freedom;Goals;Health;health care availability;Health Care Costs;health disparity;Health education;Health Educators;Health Insurance;Health Professional;Health system;Healthcare;Healthcare Systems;Hispanic;Hospitals;Household;Hypertension;Improve Access;Individual;Infrastructure;innovation;Institution;Insurance Coverage;Journals;Language;Latino;Legal Status;Letters;Linguistics;Location;Malignant Neoplasms;Mass Media;Medical;Medical center;medical specialties;Medicine;Methodist Church;metropolitan;Minority Access;minority communities;Minority Groups;Minority Health Research;Minority Participation;Mission;mortality;Nongovernmental Organizations;Nonprofit Organizations;Obesity;Office Visits;Outcome;Outcomes Research;outreach;Participant;Population;Principal Investigator;Process;programs;Publications;Publishing;racial diversity;Radio;Recording of previous events;Reporting;Research;research study;Research Support;Resources;school district;Services;social media;social stigma;Students;Surveys;symposium;Technology;Telemedicine;Texas;Textbooks;trend;trial comparing;Trust;Underrepresented Minority;United States;Universities;Update;Vision;Wait Time;web site;Work

PROJECT_TITLE: CBMHR Community Engagement Core


ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: OVERALL PROJECT NARRATIVE Cancer is a genetic disease driven by somatic or inherited mutations and, thus, genomic technologies, particularly next-generation sequencing and bioinformatic analysis, have made significant impact on cancer diagnosis, management, and treatment. However, unlike laboratory protocols and benchwork, researchers find it difficult to bring the necessary expertise in bioinformatic data analysis into their labs. The support of this R50 award will allow Dr. Lopez- Giraldez to provide broader bioinformatics analysis access and training to Yale Cancer Center researchers, and to expedite the progress, enable innovative NGS technologies, and enrich the scope of their research.

PI_NAMEs: LOPEZ GIRALDEZ, JUAN FRANCISCO (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: anti-cancer research;Area;Award;Bioinformatics;bioinformatics tool;Cancer Biology;cancer diagnosis;Cancer Science;cancer therapy;cancer type;Comprehensive Cancer Center;Data;Data Analyses;data analysis pipeline;design;Educational Activities;Educational workshop;Future;Genetic Diseases;genome analysis;Genomics;Goals;Inherited;innovation;insight;Journals;Laboratories;Malignant Neoplasms;Medicine;Mentors;method development;Mutation;NCI Center for Cancer Research;next generation sequencing;Organism;prevent;programs;Protocols documentation;Publications;Research;Research Activity;Research Personnel;Resource Sharing;Screening for cancer;Services;skills;Standardization;Students;Techniques;Technology;tool;Training;Training and Education;Work;Yale Cancer Center

PROJECT_TITLE: Cancer Bioinformatics: Data analysis and method development for the Yale Cancer Center


NIH_SPENDING_CATS: Aging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Neurosciences;Prevention;Stroke

ORG_CITY: BOSTON

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

ORG_STATE: MA

PHR: PROJECT NARRATIVE Atrial fibrillation (AF) is an important risk factor for recurrent stroke that can be effectively mitigated with anticoagulation if detected. Implantable loop recorders (ILRs) are the most sensitive method to detect paroxysmal AF, but universal ILR placement is suboptimal because ILRs are resource-intensive and only 30% of patients who receive ILR after stroke are diagnosed with AF. To test the hypothesis that using individual AF risk estimation can improve the appropriateness of overall ILR use in a resource-effective manner, the proposed research seeks to identify healthcare settings in which a risk-guided approach will be most impactful, develop a post-stroke AF risk estimation tool, and pilot test the tool to assess acceptability, adoption, and validity prior to testing it in a randomized trial.

PI_NAMEs: KO, DARAE  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Accounting;administrative database;Adoption;Algorithms;Anticoagulation;arm;Atrial Fibrillation;Award;Awareness;Benchmarking;Biometry;Boston;Calibration;Caring;Characteristics;Clinical;clinical risk;Clinical Trials;cohort;comorbidity;Complication;cost;Data;Databases;demographics;Derivation procedure;design;Detection;Diagnosis;Echocardiography;effectiveness trial;Electrocardiogram;experience;follow-up;Future;Goals;Guidelines;health care service utilization;health care settings;Health system;Healthcare;Hospitals;Implant;improved;Individual;innovation;Inpatients;Insurance Coverage;Intervention;Ischemic Stroke;K-Series Research Career Programs;Knowledge;Medical center;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Methods;Modeling;Monitor;National Heart, Lung, and Blood Institute;Neurologist;new technology;Nurse Practitioners;patient population;Patient risk;Patients;Pattern;Physicians;pilot test;point of care;Population;population health;post stroke;predictive modeling;Prevention;Prevention strategy;randomized trial;Recommendation;Recurrence;Research;Research Personnel;Research Priority;Resources;Risk;Risk Estimate;Risk Factors;risk prediction model;Rotation;Sample Size;Sampling Studies;Scientist;screening;Secondary Prevention;Services;Stroke;stroke patient;Stroke prevention;stroke survivor;stroke therapy;Testing;Time;tool;Training;Translating;trial design;usability;Validation;Variant;Veterans Health Administration;Work

PROJECT_TITLE: Risk-Guided Atrial Fibrillation Surveillance in Ischemic Stroke

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Nanotechnology;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

PI_NAMEs: XIE, HUAN  (contact)

PROJECT_TERMS: absorption;Address;advanced prostate cancer;Adverse reactions;Affinity;African American;African American population;Agreement;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;Androgens;Animal Model;Antigen Targeting;antitumor effect;Area;Award;Binding;Biological Availability;Caco-2 Cells;Cancer Etiology;Cancer Patient;Cell Culture Techniques;Cell model;Cessation of life;Characteristics;Chemosensitization;chemotherapy;clinical application;Clinical Data;Clinical Research;Clinical Trials;Collaborations;Combined Modality Therapy;Communities;community engagement;CWR22Rv1;Data;deprivation;Disease;docetaxel;Dose;drug candidate;Drug Delivery Systems;Drug or chemical Tissue Distribution;Drug Receptors;Drug Targeting;Environment;enzalutamide;Enzymes;Evaluation;experimental study;fighting;first-in-human;FOLH1 gene;Folic Acid;Food;Formulation;Fostering;Future;Gene Expression;Genetically Engineered Mouse;Goals;Hormones;in vivo;Incidence;indexing;Institution;Intestines;Intravenous;intravenous administration;Investigational Drugs;Investigational New Drug Application;Legal patent;lipid nanoparticle;Liposomes;Magic;male;Malignant neoplasm of prostate;Marketing;Mediating;Medical;Membrane;men;Metabolism;Minority Health Research;minority student;Modeling;Monitor;Morphology;mortality;mouse model;nanodrug;New Drug Approvals;new therapeutic target;novel;novel strategies;novel therapeutics;Outcome;overexpression;Particle Size;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;pharmacodynamic model;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Polymers;preclinical study;Primates;prostate cancer cell;prostate cancer cell line;Publications;Race;Rattus;Reaction;Receptor Signaling;Recurrence;Regimen;Research;Research Infrastructure;response;Role;Series;Site;Solid;standard care;Statistical Data Interpretation;success;Surface;synergism;tacrolimus binding protein 4;Tacrolimus Binding Proteins;targeted treatment;Techniques;Texas;Therapeutic;therapeutic development;Training;tumor;tumor growth;tumor xenograft;United States;Universities;Xenograft Model;Xenograft procedure;zeta potential

PROJECT_TITLE: Targeted Nano-drug-delivery-systems of Frist-in-class Drugs for CRPC: PK/PD Evaluation and Combination Therapy


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Lung;Lung Cancer;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Project Narrative Although targeted anti-cancer therapeutics have improved patient outcomes, benefits can be short-lived and new approaches are needed to prevent the emergence of drug resistance. We aim to determine if CDK12/13 inhibition can prevent drug resistance in combination with targeted agents and use our new inhibitors to reveal the complexities of acquired drug resistance. Thus, the proposed research is directly relevant to NIH’s mission – to fuel discovery, reduce illness and disability.

PI_NAMEs: DUCKETT, DEREK RONALD (contact);HAURA, ERIC B.;MONASTYRSKYI, ANDRII

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: acquired drug resistance;Affect;analog;anti-cancer;anti-cancer therapeutic;anticancer activity;Apoptosis;Biochemical;Biological Assay;Biological Models;Brain;Breast Cancer Treatment;Bypass;cancer cell;Cancer Patient;Cells;Chemicals;chemotherapy;Cisplatin;clinical development;combat;Combined Modality Therapy;Cyclin-Dependent Kinases;Data;design;Development;disability;Disease;Disseminated Malignant Neoplasm;Dose;Drug Kinetics;Drug resistance;Drug Targeting;Drug Tolerance;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;Epithelium;ERBB2 gene;Evaluation;Fatty acid glycerol esters;first-in-human;fluorescence imaging;FRAP1 gene;Future;Genes;Genetic Transcription;Goals;Growth Factor Receptors;Image;immune resistance;Immune system;Immunocompetent;immunoregulation;improved;in vivo;ineffective therapies;inhibitor;innovation;insight;Investigational Drugs;kinase inhibitor;KRAS2 gene;Lead;Ligands;lung cancer cell;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;mammary;Mediating;Mesenchymal;Metabolism;Microsomes;Mission;Modeling;Molecular;Molecular Probes;Mutation;Neoplasm Metastasis;neoplastic cell;New Agents;Non-Small-Cell Lung Carcinoma;novel;novel strategies;novel therapeutics;Oncogenes;overexpression;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacotherapy;phosphoproteomics;Play;posttranscriptional;pre-clinical;prevent;programs;Proliferating;Property;Proteomics;Receptor Signaling;Reporter;Reporting;Research;research clinical testing;Resistance;Resistance development;resistance mechanism;response;Role;safety assessment;Signal Transduction;single-cell RNA sequencing;small molecule;Solubility;Stress;stressor;Structure;success;targeted agent;targeted treatment;Testing;therapy resistant;three-dimensional modeling;Transcription Alteration;Transcription Process;Transcriptional Regulation;transcriptome sequencing;translational approach;Trastuzumab;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor progression;United States National Institutes of Health;Work;Xenograft Model

PROJECT_TITLE: Developing CDK12 inhibitors to overcome therapy resistance in HER2+ and KRAS driven breast and lung cancers

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: EDINBURG

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Chromosome structures and genome integrity are dynamically maintained, and newly replicated DNAs must be accurately segregated into two daughter cells. These processes are controlled by various DNA binding proteins, and their malfunctioning leads to various abnormalities such as cancer and changes in chromosome structure. The PI’s laboratory will utilize novel single-molecule and biophysical techniques to elucidate how these proteins function on a molecular level.

PI_NAMEs: KIM, HYEONGJUN  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Accounting;ATP phosphohydrolase;Bacteria;Bacterial Chromosomes;Binding;Binding Proteins;Biological Assay;Biology;biophysical techniques;Cellular biology;Chromatin Loop;Chromosome Segregation;Chromosome Structures;Chromosomes;Closure by clamp;cofactor;Complex;CTPase;Cytidine;Data;daughter cell;Disease;DNA;DNA biosynthesis;DNA Sequence;DNA Structure;DNA-Binding Proteins;DNA-Protein Interaction;Environment;Enzymes;Future;genetic information;Genetic Transcription;genome integrity;Genome Stability;Goals;Hydrolysis;Immunoprecipitation;In Vitro;in vivo;Laboratories;Link;Maintenance;Malignant Neoplasms;Measurement;Modeling;Molecular;Nature;novel;Process;programs;protein complex;protein function;Proteins;recruit;Replication Origin;Research;Role;segregation;single molecule;Site;Slide;Surface Plasmon Resonance;System;Techniques;Theoretical model;Thinking;translational genetics;tripolyphosphate;Variant;Work

PROJECT_TITLE: Molecular basis of bacterial chromosome segregation and organization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Notch2 is a key signal responsible for the development and maintenance of functionally poised marginal zone B (MZ B) cells, but whether Notch2 engenders these efficient effector programs in MZ B cells is not well understood. This proposal will investigate the mechanisms that amplify mitotic and plasma cell (PC) responses in Notch2-experienced cells and apply them in a DNA vaccine setting for SARS-CoV-2 receptor binding domain (RBD). These findings will elucidate strategies to augment B cell responses in sub-optimal vaccine settings.

PI_NAMEs: LONDREGAN, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Adopted;Adoptive Cell Transfers;Agonist;anti-IgM;Antibodies;Antibody Diversity;Antibody Formation;Antibody Response;Antigen Receptors;Antigens;B Cell Proliferation;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Biochemical;Biochemical Pathway;Cell Cycle Regulation;Cell Differentiation process;Cell division;Cell Physiology;Cell Survival;Cells;cellular transduction;cohort;Cohort Analysis;Complex;congenic;COVID-19 vaccination;COVID-19 vaccine;Data;Development;DNA;DNA Vaccines;Event;Exhibits;experience;experimental study;Family member;Fibroblasts;Fostering;Frequencies;Gene Expression;Gene Expression Profile;Genes;Heterophile Antigens;Hour;Humoral Immunities;Immunity;Immunoglobulin-Secreting Cells;improved;In Vitro;Label;Ligands;Ligation;Link;Longevity;Lymphoid Follicle;Maintenance;mathematical analysis;mathematical model;Membrane;Memory;Microbe;Mitosis;Mitotic;Molecular;Mutation;neutralizing antibody;notch protein;pathogen;Pathway interactions;plasma cell differentiation;Plasma Cells;Poly I-C;Population;Probability;Process;programs;Proliferating;Readiness;receptor;receptor binding;response;Rest;RNA Viruses;SARS-CoV-2 immunity;Signal Induction;Signal Transduction;Sinus;Spleen;Stimulus;Stromal Cells;System;Testing;Time;TLR3 gene;tool;transcriptome sequencing;Vaccination;vaccination strategy;Vaccine Design;vaccine development;vaccine response;Vaccines;Vascular blood supply

PROJECT_TITLE: Notch2 Amplification of B Cell Division and Differentiation Fates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Biotechnology;Cancer

PHR: Project Narrative The importance of collagen in cancer biology has been well-defined, serving to regulate the tumor microenvironment through increased density of the extracellular matrix and dysregulation of cell signaling. The interaction between collagen and the discoidin domain receptor type 2 (DDR2) is a key cancer target that contributes to tumor proliferation and metastasis. This application proposes to develop linked and cyclic collagen mimetic peptides to target the collagen-DDR2 interaction, constructing a set of biochemical tools that will facilitate new discoveries surrounding the role of collagen in cancer biology with potential applications in drug discovery.

PI_NAMEs: RAFIZADEH, DIANE NAAVA (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Affect;Affinity;Binding;Biochemical;biochemical tools;Biological;Biological Assay;Biology;biophysical properties;Biophysics;Breast;Calorimetry;Cancer Biology;cancer cell;Cells;Cellular biology;chemical property;Chemicals;Chemistry;Circular Dichroism;Collagen;collagenase;comparison control;Coupled;Crystallography;Cyclization;density;design;Development;Diazomethane;discoidin receptor;drug discovery;Entropy;Environment;epithelial to mesenchymal transition;extracellular;Extracellular Matrix;Fellowship;Fibrillar Collagen;Foundations;Glycine;Goals;Human;Human body;Hydroxyproline;Immune;improved;In Vitro;in vivo;innovation;Left;Link;Lung;Malignant Neoplasms;Mammalian Cell;Measures;Mediating;Medical;medical schools;melting;Methodology;Methods;miniaturize;Modality;Modification;Nature;Neoplasm Metastasis;Neoplasms;novel;novel therapeutics;Organic Synthesis;organizational structure;Pennsylvania;Peptide Synthesis;Peptides;peptidomimetics;Periodicity;Phase;Phosphotransferases;Physicians;Plant Resins;Polymers;polyproline;Positioning Attribute;Proliferating;Property;protein protein interaction;Proteins;Publishing;Reagent;Receptor Protein-Tyrosine Kinases;Regulation;Research Personnel;Role;Scientist;Series;Severities;Signal Transduction;Signal Transduction Induction;Signal Transduction Pathway;skills;Solid;Structure;System;Temperature;Testing;therapeutic development;therapeutic target;Tissues;tool;Training;Training Programs;Trinucleotide Repeats;triple helix;tumor;tumor microenvironment;tumorigenesis;Tyrosine Phosphorylation;Universities;unnatural amino acids;Western Blotting;Work;X-Ray Crystallography

PROJECT_TITLE: Synthesis and design of macrocyclic collagen mimetic peptides for targeting the cancer-implicated DDR2 kinase

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


PHR: Project Narrative Organization of the mammalian genome is one mechanism that regulates gene expression, cellular identity, and disease. Mutations in the LMNA gene result in altered chromatin organization, nuclear morphology defects, and dilated cardiomyopathy, which is abrogated upon co-deletion of SUN1 in a mouse model. The proposed studies will begin to elucidate the mechanisms underlying how nuclear-cytoskeleton interactions via the LINC complex are critical to the maintenance of genome organization and cellular function in cardiomyocytes.

PI_NAMEs: SHEN, KAITLYN MARIE (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Address;Affect;Area;Atomic Force Microscopy;Biological Assay;Cardiac Myocytes;Cell Nucleus;Cell Physiology;cell type;Cells;Characteristics;Chromatin;Chromosomes;Clinical;Collaborations;Complex;Cytoskeleton;Data;Defect;Development;Dilated Cardiomyopathy;Disease;disease phenotype;Elasticity;experimental study;Gene Expression;Gene Order;Gene Silencing;Genes;Genetic Diseases;Genetic study;Genome;genome-wide;Genomic approach;Genomics;Goals;heart function;Heterochromatin;Human Genetics;Image;imaging approach;Impairment;improved;insight;Ion Channel;knock-down;Lamin Type A;Lamins;Link;Maintenance;mammalian genome;Measures;Mechanics;Mediating;Microscopy;Missense Mutation;Modeling;Molecular;Morbidity - disease rate;Morphology;mortality;Motion;mouse model;Muscle;mutant;Mutant Strains Mice;Mutate;Mutation;novel;Nuclear;Nuclear Envelope;Nuclear Lamina;Pathogenesis;Pathogenicity;Patients;Peptides;Peripheral;Phenotype;Physiological;population based;Positioning Attribute;preservation;prevent;Process;programs;Property;Proteins;Publishing;Regulatory Element;release of sequestered calcium ion into cytoplasm;Role;Striated Muscles;Surface;Testing;Tissues;transcriptome sequencing;transcriptomics;Variant;viscoelasticity;Work

PROJECT_TITLE: Deciphering the role of cytoskeletal-nuclear interactions in peripheral chromatin organization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Orthopoxviruses;Rare Diseases

PHR: PROJECT NARRATIVE Poxviruses pose a substantial public health threat to the worldwide population even with FDA-approved vaccines and therapeutics, as evidenced by the recent global outbreak of Mpox. Although we know poxviruses function predominately by modulating host immune responses, the specific genes responsible for their extreme virulence remain ill-defined, which limits the capacity to design novel antiviral therapeutics. This proposal will define the molecular mechanisms of a conserved poxvirus virulence factor that is essential for pathogenesis and antagonizes both the innate and adaptive arms of the immune system to inform our comprehension of poxviral virulence determinants and identify novel strategies to combat poxvirus infections.

PI_NAMEs: CARRO, STEPHEN DAVID (contact)

PROGRAM_OFFICER_NAME: KNISELY, JANE M

PROJECT_TERMS: adaptive immune response;adaptive immunity;Amino Acid Sequence;Amino Acids;antagonist;Anti-viral Agents;arm;Biological Assay;Biology;C-terminal;career;CD8-Positive T-Lymphocytes;Cell membrane;cell type;Cells;Cellular biology;Collaborations;combat;Communication;Comprehension;Coupled;Cowpox;Cytolysis;Cytoplasm;Data;Data Analyses;design;Disease Outbreaks;Ectromelia;Event;Family;Family member;FDA approved;Flow Cytometry;Foundations;Genes;Glycoproteins;Goals;Home;Immune response;Immune system;Immunoglobulin Domain;Immunology;immunoregulation;In Vitro;in vitro Assay;Individual;Infection;Infectious Ectromelia;Innate Immune Response;insight;Knowledge;Link;Mammals;Mediating;Membrane;Membrane Glycoproteins;Mentorship;MHC Class I Genes;Modeling;Molecular;Molecular and Cellular Biology;Molecular Biology;Monkeypox;mortality;Mus;Mutagenesis;Mutagens;N-terminal;Natural Immunity;Natural Killer Cells;NK Cell Activation;novel;novel strategies;Orthopoxvirus;Outcome;pathogen;Pathogenesis;Pathogenicity;Peptides;Phase;Population;post-doctoral training;Post-Translational Protein Processing;Poxviridae;Poxviridae Infections;Predisposition;Principal Investigator;protein complex;Protein Family;Protein Fragment;protein function;protein structure;Proteins;Proteolytic Processing;Public Health;Publishing;Recombinant Proteins;Recombinants;Research Proposals;Role;Site;small molecule;Smallpox;structural biology;structural determinants;Structure;Structure-Activity Relationship;Surface;T-Cell Activation;T-Lymphocyte;Techniques;Technology;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;trafficking;Training;Transfection;Vaccines;Viral;Viral Proteins;Virulence;Virulence Factors;Virus;Western Blotting;Work

PROJECT_TITLE: Uncovering the molecular underpinnings of C15, a potent orthopoxvirus virulence factor

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Infectious Diseases;Nutrition;Patient Safety;Prevention;Urologic Diseases

ORG_CITY: KANSAS CITY

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE The ultimate goal of this research is to unlock the potential of nutrition interventions to improve outcomes, survival, and quality of life in patients with cancer. The aims follow the National Cancer Institute's (NCI) strategic objectives to improve the quality of life for cancer survivors and to use the National Clinical Trials Network for a rapid translation of findings into better clinical outcomes from cancer treatment.

PI_NAMEs: HAMILTON-REEVES, JILL REEVES (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Address;Amino Acids;Antibiotics;Arginine;arm;Calories;Cancer Patient;cancer surgery;cancer therapy;Caring;Cells;Clinical;clinical practice;Clinical Trials;Complication;Consumption;cost;Cystectomy;cytokine;Data;Death Rate;design;dietary;Dietary Intervention;Disease-Free Survival;Double-Blind Method;Dual-Energy X-Ray Absorptiometry;effectiveness evaluation;experience;Fatty Acids;Fortification;Future;Goals;healing;Immune;immune function;Immune response;Immune system;Immunomodulators;immunoregulation;Impairment;improved;improved outcome;Infection;Infection prevention;infection rate;Inflammation;Inflammatory;Inflammatory Response;innovation;Intake;Interleukin-6;Intervention;Intestines;Laboratories;Lymphocyte;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Metabolism;Methods;microbiome;mortality;multi-site trial;Muscle;Muscular Atrophy;Myeloid-derived suppressor cells;National Cancer Institute;National Clinical Trials Network;neutrophil;Nitrogen;Nucleotides;Nutrient;nutrient metabolism;nutrition;Nutritional status;Nutritional Support;Omega-3 Fatty Acids;operation;Operative Surgical Procedures;Oral;Outcome;parent grant;Pathway interactions;Patient-Focused Outcomes;Patients;Perioperative;Phase;Pilot Projects;pilot trial;Postoperative Complications;Postoperative Period;preservation;Procedures;Quality of life;quality of life for cancer survivors;Radical Cystectomy;Randomized;readmission rates;reconstruction;Research;Resistance to infection;restraint;Risk;Route;Running;skeletal muscle wasting;Southwest Oncology Group;standard care;Supplementation;surgery outcome;Surgical complication;Surgical Oncology;Testing;Translations;Urine;Urologic Oncology;Vitamin A;Work;wound healing

PROJECT_TITLE: Effect of Immune-Enhancing Nutrition on Radical Cystectomy Outcomes- MERIT extension