NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Neurosciences

ORG_CITY: SARASOTA

ORG_NAME: ROSKAMP INSTITUTE, INC.

PHR: Organophosphate (OP) pesticides, such as chlorpyrifos (CPF) are among the most toxic chemicals known to mankind and their use in Syria by terrorist on innocent civilians highlights the need to identify countermeasure approaches against these chemical threat agents. Many of the symptoms experienced by civilians intoxicated with OP chemicals resemble those associated with autoimmune disorders and, therefore, we will identify mechanisms associated with OP induced immune dysfunction. The proposed work will help identify mechanisms which could lead to future development of treatments that can improve the health of individuals who may suffer from chronic multisymptom illnesses after being exposed to such chemicals.

PI_NAMEs: ABDULLAH, LAILA  (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Accidents;Acids;Acute;adaptive immune response;adaptive immunity;adduct;Adverse effects;Affect;Albumins;Amino Acids;Antibodies;Antibody Formation;Antidotes;Antigens;Area;Astrocytes;Autoimmune;Autoimmune Diseases;B-Lymphocytes;Biological Markers;Blood;Brain;Cells;Central Nervous System;central nervous system injury;chemical threat;Chemical Warfare;Chemicals;Chlorpyrifos;Chronic;Chronic Fatigue Syndrome;Classification;Cognitive;Cross Reactions;Data;Development;Disease;Encephalitis;Environmental Exposure;experience;Exposure to;Future;Gases;Headache;Health;Health system;Human;Immune;immune activation;Immune response;Immune system;Immune System Diseases;Immune Targeting;Immunologic Stimulation;improved;in vivo;Individual;innovation;Intoxication;Iran;Iraq;Mass Spectrum Analysis;Mediating;medical countermeasure;Methods;Microglia;Morbidity - disease rate;mouse model;Mus;Muscle Fatigue;Muscle Weakness;nerve agent;nerve gas;neuroinflammation;Neurons;neurotoxicity;novel;Oral;organophosphate poisoning;Organophosphates;Peripheral;Peripheral Nervous System;Persian Gulf Syndrome;pesticide poisoning;Pesticides;Plasma;Poison;Poisoning;Population;programs;Proteins;pyrethroid;Quality of life;Reporting;response;Role;Sarin;Security;standard of care;Subway;Sydenham Chorea;Symptoms;Syria;T memory cell;T-Cell Activation;Testing;therapy development;Tokyo;Toxic effect;toxic organophosphate insecticide exposure;Tyrosine;Veterans;Woman;Work

PROJECT_TITLE: The role of adaptive immunity in organophosphate induced CNS injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-F(54)]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE – PUBLIC HEALTH RELEVANCE A key goal of “Healthy People 2030” is to improve health of adults through aerobic physical activity, and soccer, which is the most popular sport on earth, is an aerobic outlet for more than 25 million Americans of all ages that provides significant benefits for brain health. However, we and others have shown that repetitive subconcussive head impacts from soccer heading are associated with signs of subclinical brain injury among young adults, which impact function and may pose risk for neurodegeneration. Delineating the risk vs. benefit to cognitive performance from soccer, based upon a robust scientific foundation, can transform perception of risk by stakeholders and facilitate guidanceon soccer participation for young adult players with decades of future needs, and potential to impact their wellbeing, healthcare footprint and productivity for decades.

PI_NAMEs: LIPTON, MICHAEL LAWRENCE (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Adult;Adverse effects;Aerobic;Age;Alleles;American;Anisotropy;apolipoprotein E-4;Attenuated;attenuation;Benefits and Risks;Brain;Brain Concussion;brain health;Brain Injuries;Brain-Derived Neurotrophic Factor;central nervous system injury;Cognitive;cognitive change;cognitive enhancement;cognitive function;cognitive performance;cognitive testing;combat;Diffusion;Diffusion Magnetic Resonance Imaging;Enrollment;Equilibrium;Exhibits;Exposure to;Follow-Up Studies;Foundations;Future;genetic variant;Goals;Harm Reduction;head impact;Health;Healthcare;Impairment;improved;indexing;injury and repair;insight;Joints;Knowledge;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Mediation;Mediator;Morbidity - disease rate;Myelin;Myelin Water Imaging;myelination;Nerve Degeneration;neuroimaging;Outcome;Participant;Personal Satisfaction;Persons;Physical activity;Planet Earth;Play;Productivity;protective effect;public health relevance;Reporting;Risk;risk perception;Role;Sampling;Soccer;Sports;Structure;subconcussion;Testing;Time;VO2max;Water;white matter;white matter change;Work;young adult

PROJECT_TITLE: Heading and Soccer: understanding cognitive risks, benefits, and the potentialmediating role of white matter

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Transplantation

ORG_CITY: WINSTON-SALEM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Genetic information in the apolipoprotein L1 gene (APOL1) from African American donors of kidneys and transplant recipients may provide more accurate assessments of the likelihood of long-term survival of transplanted kidneys and optimize matching of donors with recipients. This application is submitted in response to the National Institutes of Health request for renewal applications for the APOL1 Long-term Kidney Transplant Outcomes Network (APOLLO) Scientific and Data Research Center prospectively evaluating effects of donor and recipient APOL1 genotypes in kidney transplants from African American donors performed at US transplant programs. Results from the national APOLLO study have the potential to transform the processes of organ allocation and informed consent in kidney transplantation, optimize survival of patients after kidney transplantation, and determine the safety of living kidney donation.

PI_NAMEs: ALLRED, NICHOLETTE D.;FREEDMAN, BARRY IRA (contact);REBOUSSIN, DAVID M;STRATTA, ROBERT J

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acute;Adult;African American;African American population;African ancestry;Allografting;American;Ancillary Study;APOL1 gene;Apolipoproteins;Archives;biobank;Bioinformatics;Biometry;Childhood;Chronic Kidney Failure;Clinical;clinical center;Clinical Data;Cohort Studies;Collection;Communities;Creatinine;Data;Data Analyses;data quality;Databases;Decision Making;design;Development;Disparity;DNA;donor-specific antibody;Eligibility Determination;Engraftment;Enrollment;Ensure;Ethicists;Ethics;ethnic disparity;Ethnic Population;European;Evaluation;Failure;Genes;Genetic;genetic information;genome-wide;Genotype;Glomerular Filtration Rate;graft function;Graft Survival;Health;Health Care Costs;Health protection;Histology;Human Resources;improved;Individual;Informed Consent;Institutional Review Boards;Kidney;kidney allograft;Kidney Transplantation;Laboratories;Leadership;Link;living kidney donor;Manuals;medical schools;Monitor;Multicenter Studies;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Observational Study;Operative Surgical Procedures;Organ;organ allocation;organ procurement transplantation network;Organ Procurements;Outcome;Outcome Assessment;Participant;Patients;Physicians;Population;post-transplant;precision medicine;Predisposition;primary outcome;Procedures;Process;programs;prospective;Prospective Studies;Proteinuria;Protocols documentation;Publications;Quality of life;racial population;recruit;Renal function;Reporting;repository;Research;Research Personnel;Resources;response;Retrospective Studies;Risk;risk variant;Safety;Sampling;Serum;Sickle Hemoglobin;skills;Statistical Data Interpretation;Structure;Time;tool;Transplant Recipients;Transplantation;United Network for Organ Sharing;United States National Institutes of Health;Universities;Variant;Virus Diseases;Vital Status;web site;Work;working group

PROJECT_TITLE: 14/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Scientific Data Research Center


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The Kids First Data Resource Core (KFDRC) is composed of three core, the Administrative and Outreach Core (AOC), the Data Coordination Core (DCC) and the Data Resource Core (DRC), which together will facilitate making Kids First, and other relevant interoperable datasets, Findable, Accessible, Interoperable and Reusable (FAIR). In this phase, the KFDRC will expand and scale its efforts for continued data generation, new data modalities, emerging interoperability initiatives and wider range of users across computational and biological researchers, to clinicians to patients and patient advocates. These efforts will continue to maximize the potential for novel discovery and better understanding across a multitude of pediatric diseases and disorders for clinical translation.

PI_NAMEs: CARROLL, ROBERT J;DIGIOVANNA, JACK ;FERRETTI, VINCENT ;GROSSMAN, ROBERT L.;HEATH, ALLISON ;RESNICK, ADAM CAIN (contact);TAYLOR, DEANNE MARIE;VOLCHENBOUM, SAMUEL

PROGRAM_OFFICER_NAME: FOURNIER, MARCIA VASCONCELLOS

PROJECT_TERMS: Acceleration;Address;Advocate;Architecture;Authorization documentation;base;Biological;Birth;Certification;Child;Childhood;Clinical;clinical decision support;clinical translation;cloud based;cloud platform;cohort;Communities;Data;data access;Data Commons;data ecosystem;data interoperability;data modalities;data resource;data reuse;Data Science;Data Set;data sharing;Development;Disease;Distributional Activity;Down's Syndrome;empowerment;Ensure;Environment;Etiology;experience;FAIR principles;Fostering;Funding;Generations;Growth;Hand;Infrastructure;innovation;Institution;interoperability;Investigation;Knowledge;Leadership;life span;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;Mission;multidisciplinary;new technology;novel;operation;Outcome;outreach;Patients;Pediatric Research;Phase;Phenotype;programs;Research;Research Personnel;Resources;Role;Services;software development;Structural Congenital Anomalies;success;Testing;Time;tool;translational impact;Trust;United States National Institutes of Health;Update;Vision;Work

PROJECT_TITLE: Gabriella Miller Kids First Pediatric Data Resource Center: Advancing Collaborative Platform-Enabled Data-Driven Discovery at the Intersection of Childhood Development and Cancer


PI_NAMEs: RESNICK, ADAM CAIN (contact)

PROJECT_TERMS: Advocate;Child;Childhood;Clinical;Collection;Communication;Communities;Data;data ecosystem;data resource;data tools;Development;Documentation;Education;Ensure;Evaluation;Event;experience;Foundations;Goals;improved;innovation;Logistics;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuscripts;meetings;novel;operation;outreach;Patients;Persons;Preparation;programs;Reporting;Research;Research Personnel;Resources;Schedule;Seasons;Structural Congenital Anomalies;timeline;tool;Training;Training and Education;Training Programs;Triage;United States National Institutes of Health;virtual

PROJECT_TITLE: Administrative and Outreach Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-S]


NIH_SPENDING_CATS: Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: Acceleration;Address;Adoption;analytical tool;Artificial Intelligence;Authorization documentation;Automation;Automobile Driving;Big Data;Binding;Child;Childhood;Clinical;Clinical Data;cloud based;cloud platform;cohort;Communities;Computer software;cost;Data;data access;Data Analyses;data interoperability;data management;data portal;data resource;Data Scientist;Data Set;database of Genotypes and Phenotypes;Databases;design;Development;Disease;empowerment;Family member;Fast Healthcare Interoperability Resources;Feedback;Foundations;Future;Genes;Genetic Predisposition to Disease;genomic data;Germ Lines;Growth;improved;Infrastructure;innovation;interoperability;Language;Leadership;Life Cycle Stages;light weight;Machine Learning;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;Metadata;Monitor;open data;open source;Patients;Pattern;programs;Research;Research Personnel;Resources;Secure;Services;Structural Congenital Anomalies;support tools;Sustainable Development;Techniques;Technology;Time;tool;Trust;United States National Institutes of Health;Variant;virtual;Work

PROJECT_TITLE: Data Resource Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: HEATH, ALLISON  (contact)

PROJECT_TERMS: Acceleration;Agreement;analytical tool;Automation;Benchmarking;Bioinformatics;bioinformatics pipeline;Child;Childhood;Clinical;Clinical Data;clinical translation;Collaborations;Collection;Communities;community building;Computer software;Congenital Abnormality;Data;Data Analyses;Data Collection;data curation;data ecosystem;data exchange;data exploration;data format;data ingestion;data integration;data interoperability;data modalities;Data Reporting;data repository;data resource;Data Set;Data Sources;data warehouse;database of Genotypes and Phenotypes;Development;Disease;diverse data;Documentation;empowerment;Environment;epigenomics;experience;FAIR principles;Family;Fast Healthcare Interoperability Resources;Funding;Genetic;Genetic Annotation;genetic variant;Genome;genome resource;genomic data;Genomics;Genotype;Human;improved;Individual;Ingestion;Intake;interest;interoperability;Investigation;Language;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuals;Metadata;Mission;model organism;multimodal data;Nature;novel;Ontology;outreach;Pharmaceutical Preparations;Phenotype;phenotypic data;Process;programs;Public Domains;Reporting;repository;Reproducibility;Research;Research Personnel;Resources;Services;Source;Standardization;success;Therapeutic;tool;Training;transcriptome sequencing;United States National Institutes of Health;usability;Variant;Vision;Work

PROJECT_TITLE: Data Coordination Core


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative The Acquired Resistance to Therapy and Iron (ARTI) Center at The University of Texas MD Anderson Cancer Center will establish a foundation for understanding the role of iron in cancer resistance to therapies and will focus on deciphering the mechanisms of acquired resistance to radiation therapy, which can be extrapolated to other types of cancer therapy. The overarching goals of the ARTI Center are: 1) to bridge the basic science mechanism of a novel type of iron-dependent cell death called ferroptosis in acquired resistance to radiation therapy with translational research in preclinical models and human patient samples; 2) to identify cohorts of patients who are at greatest risk to develop acquired radiation therapy resistance; and 3) to investigate the ability of novel therapeutic agents to re-sensitize cancer cells to radiation by inducing ferroptosis. The long-term outcomes from the ARTI Center will foster collaborations with other centers in the Acquired Resistance to Therapy Network (ARTNet), build upon and iteratively feedback into research projects focused on drug resistance and sensitivities, and ultimately lead to cancer treatment strategies tailored to the individual patient.

PI_NAMEs: GAN, BOYI  (contact);KOONG, ALBERT

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Achievement;activating transcription factor 4;Advisory Committees;Basic Science;bioluminescence imaging;cancer cell;Cancer cell line;Cancer Center;cancer imaging;Cancer Patient;cancer therapy;cancer type;Cell Death;Cell Death Induction;Cells;chemoradiation;Clinical;Clinical Trials;clinically significant;Cloning;cohort;Collaborations;Communication;Cystine;Data;determinants of treatment resistance;Development;Drug resistance;drug sensitivity;effective therapy;Esophageal Adenocarcinoma;Failure;Family;Feedback;Fostering;Foundations;Future;Genes;Genomics;Goals;Grant;Guidelines;hormone therapy;Human;Hypoxia;Hypoxia Inducible Factor;Image;Imaging Device;imaging program;Immune;Immunologics;Immunotherapy;improved;individual patient;Infrastructure;Iron;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of thorax;Malignant Neoplasms;Mediating;Medical;member;Modality;Modeling;molecular imaging;Monitor;multidisciplinary;Mus;National Cancer Institute;Nature;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Outcome;Oxidation-Reduction;Patient-Focused Outcomes;Patients;Play;Policies;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Production;Prognostic Marker;programs;Radiation;Radiation Oncology;radiation resistance;Radiation therapy;Radiation-Sensitizing Agents;radioresistant;Reagent;Recurrence;Recurrent disease;Reporter Genes;Research;Research Project Grants;Resistance;Resource Sharing;Resources;Risk;Role;Sampling;single cell sequencing;solute;stable cell line;synergism;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Agents;therapy resistant;Tracer;Transfection;Transgenic Organisms;Translating;Translational Research;treatment strategy;tumor;tumor growth;tumor hypoxia;tumor microenvironment;Tumor Suppression;University of Texas M D Anderson Cancer Center;Xenograft Model


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Esophageal Cancer;Orphan Drug;Radiation Oncology;Rare Diseases

PI_NAMEs: GAN, BOYI  (contact)

PROJECT_TERMS: Achievement;Advisory Committees;anti-cancer research;Basic Science;Benchmarking;cancer cell;Cancer Patient;cancer type;chemoradiation;Clinical;Cloning;cohort;Collaborations;Combined Modality Therapy;Communication;conflict resolution;Data;data management;data sharing;Development;Direct Costs;Doctor of Philosophy;Ensure;Esophageal Adenocarcinoma;esophageal cancer patient;Evaluation;Faculty;Funding;Genomics;Goals;Guidelines;Human;Hypoxia;Image;Imaging Device;Immunotherapy;Infrastructure;Institution;Intellectual Property;interest;Iron;Knowledge;Leadership;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Measures;meetings;member;molecular imaging;Mus;Myeloid Cells;National Cancer Institute;neoplastic cell;novel therapeutics;Office of Administrative Management;outreach;Patients;peer;Performance;Policies;Pre-Clinical Model;Principal Investigator;Process;Production;programs;Progress Reports;Radiation;radiation resistance;Radiation therapy;Radiation-Sensitizing Agents;Reporter Genes;Research;Research Project Grants;Resistance;Resource Sharing;Resources;Risk;Role;Sampling;stable cell line;standard of care;Students;Technology;Testing;Therapeutic Agents;therapy resistant;tool;Training;Transfection;Transgenic Organisms;Translating;Translational Research;tumor;tumor growth;tumor hypoxia;Wages;web site;Work;Xenograft Model

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Esophageal Cancer;Orphan Drug;Radiation Oncology;Rare Diseases

PI_NAMEs: PIWNICA-WORMS, DAVID  (contact)

PROJECT_TERMS: activating transcription factor 4;Animal Model;Animals;Basic Science;Biochemical;Biological;Bioluminescence;bioluminescence imaging;Biosensor;Cancer Biology;cancer cell;Cancer Center;cancer imaging;Cell Culture Techniques;Cell Line;Chemicals;chemoradiation;Clinical;cohort;Collaborations;Communities;Computer software;Custom;Data;design;Esophageal Adenocarcinoma;experience;experimental study;Funding;Genetic Engineering;Genomics;Goals;Grant;Human;Human Resources;Hyperbaric Oxygenation;Hypoxia;Hypoxia Inducible Factor;Image;imaging program;imaging system;Immunotherapy;Individual;Infrastructure;inhibitor;Institution;International;Iron;knock-down;Laboratories;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant Neoplasms;Mammalian Cell;microscopic imaging;Modeling;Molecular Biology;molecular imaging;Monitor;Myeloid Cells;National Cancer Institute;novel;novel therapeutics;Patients;Plasmids;Play;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preclinical imaging;Production;Productivity;programs;Protocols documentation;Radiation;Radiation Oncology;radiation resistance;radiation response;Radiation therapy;Radiosensitization;Reagent;Reporter;Research Activity;Research Personnel;Research Project Grants;Resistance;Resource Sharing;Resources;Risk;Role;Sampling;Services;Site;Testing;Therapeutic Agents;therapy resistant;Tracer;Training;Translating;Translational Research;tumor;tumor growth;tumor hypoxia;University of Texas M D Anderson Cancer Center;virtual

PROJECT_TITLE: Molecular Imaging Core


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE This proposal is relevant to public health because it addresses a fundamental gap in understanding how DNA damaging therapies such as radiotherapy and chemotherapy lead to epigenetic alterations and treatment resistance in cancer. Addressing this knowledge gap and developing strategies to study this process will open new therapeutic avenues for cancer treatment. Therefore, the proposed research is relevant to the NIH's mission of seeking fundamental knowledge that can lengthen life and reduce illness.

PI_NAMEs: MODREK, ARAM SANDALDJIAN (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: 3-Dimensional;Address;Binding;Biological Models;cancer cell;cancer therapy;career;career development;Cell Culture Techniques;Cells;Chemotherapy and/or radiation;ChIP-seq;Chromatin;chromosome conformation capture;Chromosome Mapping;cohesin;Comet Assay;CRISPR/Cas technology;Data;demethylation;DNA;DNA Damage;DNA mapping;DNA Methylation;DNA Modification Methylases;DNA Repair;DNA sequencing;DNA-Binding Proteins;endonuclease;Enzymes;Epigenetic Process;epigenome;experimental study;Faculty;Gene Expression;Gene Expression Regulation;Genome;genome-wide;Glioblastoma;Goals;Guide RNA;histone modification;HMGB2 gene;Human;in vivo;Individual;inhibitor;innovation;insight;K-Series Research Career Programs;Knowledge;Lead;Life;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Mediating;meetings;Mentors;Mission;Modeling;Molecular Analysis;novel therapeutics;Oncogenes;Patients;Phase;Population;Post-Translational Protein Processing;Principal Investigator;Process;Public Health;Radiation;Radiation induced damage;Radiation Induced DNA Damage;Radiation therapy;Radiation-Induced Change;Radiation-Sensitizing Agents;Radiosensitization;recruit;Recurrent tumor;Regulatory Element;repaired;Reproducibility;Research;Research Personnel;Resolution;response;Role;Site;skill acquisition;small molecule inhibitor;spatiotemporal;Stress;Structure;System;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;time use;tool;Training;transcription factor;transcriptome sequencing;treatment effect;tumor;tumor growth;United States National Institutes of Health

PROJECT_TITLE: Epigenetic alterations after DNA damage repair drive treatment resistance in glioblastoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Esophageal Cancer;Lung;Lung Cancer;Orphan Drug;Radiation Oncology;Rare Diseases

PROJECT_TERMS: Anabolism;Automobile Driving;cancer cell;cancer therapy;Cell Death;Cell Line;comparative;Complement;CRISPR screen;Cystine;Data;effectiveness evaluation;Glutathione;Goals;Immunotherapy;innovation;Iron;Link;Lipid Peroxidation;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of thorax;Malignant Neoplasms;Mediating;Modeling;mutant;Normal Cell;Normal tissue morphology;novel;novel therapeutic intervention;Outcome;Pathway interactions;Radiation;radiation resistance;Radiation therapy;radiation-induced injury;Radiation-Sensitizing Agents;radioresistant;Radiosensitization;Recurrent disease;Resistance;Role;Testing;Therapeutic;Therapeutic Effect;Therapeutic Studies;therapeutically effective;therapy resistant;Toxic effect;TP53 gene;Translating;tumor;tumor microenvironment;Tumor Suppression;Xenograft procedure

PROJECT_TITLE: Ferroptosis resistance as a key driver in acquired radiation resistance


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_DEPT: NEUROSURGERY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Diffuse midline glioma (DMG) is the leading cause of death among pediatric brain tumors yet disease outcomes have not improved due to the lack of effective treatments and limited diagnostic tools. This proposal uses an innovative, multimodal treatment approach, involving mitogen- activated protein kinase (MEK) inhibition and aminolevulinic acid-photodynamic therapy, that addresses the barriers to successful DMG clinical trials and exploits the molecular composition of DMG cells to reduce morbidity and mortality. If successful, this treatment can be applied to other inoperable central nervous system (CNS) tumors.

PI_NAMEs: PRICE, GABRIELLE ALEXIA (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Address;Adult;Affect;Aftercare;aggressive therapy;Aminolevulinic Acid;antitumor effect;Apoptosis;Astrocytes;Behavior;Bioinformatics;Biological Assay;Blood;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;Brain;Brain Neoplasms;Brain Stem;Bromodeoxyuridine;cancer cell;Cause of Death;Cell Culture Techniques;Cell Cycle Arrest;Cell Death;Cell Death Induction;cell injury;cell killing;cell motility;Cell Proliferation;Cell Survival;Cells;Central Nervous System;Central Nervous System Neoplasms;Child;Childhood;Childhood Brain Neoplasm;Childhood Brain Stem Neoplasm;Clinical Trials;Combined Modality Therapy;Data;Data Set;Diagnosis;diagnostic tool;Diffuse intrinsic pontine glioma;diffuse midline glioma;Disease Outcome;Drug Delivery Systems;effective therapy;experimental study;extracellular;Extracellular Signal Regulated Kinases;extracellular signal-regulated kinase 3;Flow Cytometry;Future;Gene Expression Profile;Genetic;genetic signature;Genetically Engineered Mouse;Glioma;Immune Evasion;Immune response;Immune Targeting;immunocytochemistry;immunoregulation;improved;In Vitro;in vivo;Inhibition of Cell Proliferation;innovation;interest;Invaded;Knock-out;Light;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;MAP Kinase Gene;MAPK3 gene;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinase Kinases;Mitogen-Activated Protein Kinases;Modality;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;neoplastic cell;nerve stem cell;Oncogenic;Pathway interactions;Patients;Pattern;Phenotype;Photosensitizing Agents;pleiotropism;preclinical trial;Prognosis;Propidium Diiodide;Protein Kinase;Proteomics;protoporphyrin IX;PUVA Photochemotherapy;Radiation therapy;Reactive Oxygen Species;Receptor Protein-Tyrosine Kinases;Role;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Slice;Specimen;spheroids;Stains;standard of care;Stromal Cells;Subgroup;synergism;Testing;Therapeutic;Tracer;transcriptomics;translational therapeutics;Treatment Efficacy;treatment response;Treatment-related toxicity;tumor;Tumor Burden;tumor microenvironment;tumorigenesis;United States;Western Blotting

PROJECT_TITLE: MEK PATHWAY INHIBITION COMBINED WITH 5-AMINOLEVULINIC ACID-PHOTODYNAMIC THERAPY FOR THE TREATMENT OF DIFFUSE MIDLINE GLIOMA


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Complementary and Integrative Health;Digestive Diseases;Esophageal Cancer;Hyperbaric Oxygen;Lung;Lung Cancer;Orphan Drug;Radiation Oncology;Rare Diseases

PI_NAMEs: KOONG, ALBERT  (contact)

PROJECT_TERMS: 3-Dimensional;acquired factor;activating transcription factor 4;Anabolism;Anatomy;Area;Basic Science;biological adaptation to stress;bioluminescence imaging;cancer cell;Cancer cell line;cancer therapy;cancer type;Cause of Death;Cell Death;Cell Death Induction;Cell Physiology;cell type;chemoradiation;Clinical;Combined Modality Therapy;Cultured Tumor Cells;Cystine;Data;design;Disease;DNA Damage;efficacy evaluation;Environment;epithelial to mesenchymal transition;Esophageal Adenocarcinoma;Esophageal Neoplasms;Family;FDA approved;Genes;Genetic;Genetic Transcription;Glutathione;Goals;Hyperbaric Oxygen;Hyperbaric Oxygenation;Hypoxia;Hypoxia Inducible Factor;In Vitro;in vivo;inhibitor;Ionizing radiation;Iron;Lipid Peroxidation;Lung Neoplasms;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Mediator;member;molecular imaging;Monitor;Mus;Neoplasm Metastasis;neoplastic cell;Organoids;Oxygen;Oxygen Therapy Care;Pathway interactions;Patient Selection;pharmacologic;Play;Positron-Emission Tomography;pre-clinical;Proliferating;Radiation;Radiation induced damage;radiation resistance;Radiation therapy;Radiation Tolerance;Regulation;Resistance;response;Role;Signal Pathway;Site;small molecule;small molecule inhibitor;Solid;solute;Testing;Therapeutic;therapeutically effective;therapy resistant;Time;Tracer;transcription factor;tumor;tumor growth;tumor hypoxia;tumor metabolism;tumor microenvironment;Tumor Oxygenation;tumor xenograft;Up-Regulation;Vascular blood supply

PROJECT_TITLE: Tumor hypoxia promotes acquired resistance to radiation through ferroptosis inhibition


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Project Narrative Many underrepresented high school students lack exposure to authentic laboratory science experiences that can profoundly influence their academic performance in school and their subsequent career trajectories. Since today’s students will determine our nation’s future scientific competitiveness and need to be intelligent evaluators of new science and health advances, CityLab will use well-matched comparison studies with a diverse pre-college student population to determine whether infusing socioscientific reasoning skill development into its new gene editing curriculum supplement can not only teach students important science concepts and practices but also promote continued engagement in the biomedical sciences/STEM. This project will test the hypothesis that teaching socioscientific reasoning skills, in conjunction with laboratory- based experiences and extended participation in a community of learners, will positively impact diverse populations of students, promote their continued engagement in STEM and raise all students’ awareness of attitudes and practices that promote equity, inclusion, and diversity in STEM, inspire them towards careers in the health professions and biomedical sciences, and ultimately improve the nation’s understanding of gene editing and its role in improving human health and eradicating disease.

PI_NAMEs: DEROSA, DONALD A (contact);FRANZBLAU, CARL ;ROMNEY, CARLA A

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Area;Attitude;Awareness;Behavior;Biological Assay;Boston;California;career;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;college;Color;Communities;Computer Simulation;curriculum enhancement;Data;Decision Making;design;Development;digital;digital media;Disease;diversity and equity;diversity and inclusion;education pathway;Educational Curriculum;Educational process of instructing;effectiveness testing;efficacy testing;Elements;equity, diversity, and inclusion;Ethics;experience;Exposure to;falls;Fostering;Future;Genes;Genomics;Health;Health Occupations;high school;High School Faculty;High School Student;high standard;Human;improved;innovation;insight;Investigation;Laboratories;laboratory experience;Lead;Learning;learning community;Length;Longitudinal Studies;Measures;medical schools;Medicine;Modeling;Molecular;Molecular Biology;next generation;Next Generation Science Standards;novel;Ownership;Participant;Performance;Phase;pilot test;Population;Population Heterogeneity;Positioning Attribute;programs;Race;Readiness;Rejuvenation;Reporting;response;restriction enzyme;Role;Schools;Science;science education;science teacher;Science, Technology, Engineering and Mathematics Education;Scientific Inquiry;Secondary Schools;Seminal;Sickle Cell Anemia;Site;skill acquisition;skills;Social Environment;Social Justice;Societies;Source;STEM career;student participation;Students;teacher;Techniques;Technology;Testing;therapy development;tool;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;university student;Virtual and Augmented reality;virtual experiments;virtual reality environment;virtual reality game;virtual reality simulation;Wisconsin;Work

PROJECT_TITLE: Mystery of the Crooked Cell 2.0: CityLab's Next Generation SocioscientificApproach to Gene Editing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

PI_NAMEs: LIN, STEVEN HSESHENG (contact)

PROJECT_TERMS: base;Basic Science;Biopsy;Biopsy Specimen;cancer cell;Cancer cell line;cancer therapy;Cause of Death;Cell Death Induction;Cell Differentiation process;Cells;chemoradiation;Chemotherapy and/or radiation;Chromosome abnormality;Clinical;Communication;Complex;curative treatments;Cystine;cytokine;Data;data integration;determinants of treatment resistance;differential expression;Disease;DNA copy number;DNA sequencing;Drops;Esophageal Adenocarcinoma;Excision;Fibroblasts;Fluorescent in Situ Hybridization;Future;Gene Expression;Gene Expression Profile;Genes;Genomics;Goals;healthcare burden;Heterogeneity;humanized mouse;Hypoxia;Image;Immune;improved;In complete remission;innovation;insight;Iron;irradiation;KRAS2 gene;Link;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant Neoplasms;Maps;MDM2 gene;Mediating;Molecular;molecular imaging;Morbidity - disease rate;mortality;mouse model;Myeloid Cells;neoplastic cell;neutrophil;Neutrophil Infiltration;Nonmetastatic;Operative Surgical Procedures;Organoids;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Positron-Emission Tomography;Pre-Clinical Model;Preclinical Testing;predicting response;predictive tools;radiation resistance;Radiation therapy;Refractory;Regimen;Resistance;Resolution;response;Risk;Role;Sampling;Selection for Treatments;Signal Pathway;single-cell RNA sequencing;Societies;Solid Neoplasm;Stromal Cells;Survival Rate;Technology;Testing;therapy development;therapy resistant;Time;tissue mapping;tool;Tracer;trait;transcriptome;transcriptomic profiling;Transplant Recipients;Treatment outcome;treatment response;Treatment-related toxicity;tumor;tumor microenvironment;Tumor-infiltrating immune cells

PROJECT_TITLE: Role of genomic and microenvironment factors in conferring acquired resistance to ferroptosis to chemoradiation in esophageal adenocarcinoma


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Despite intensive efforts to develop methods for analyzing fast-growing environmentally-sequenced microbiome data, many challenges remain, and there is substantial room for improvements. We will build several methods for building better reference datasets, increasing the accuracy of proﬁling contents of microbiome samples, and ﬁnding associations between changes in the proﬁle and phenotypes of interest. Our publicly available methods will use advanced algorithms, statistics, and state-of-the-art machine learning techniques, but will adopt these techniques to incorporate a deep understanding of the evolutionary processes that shape the microbiome.

PI_NAMEs: MIR ARABBAYGI, SIAVASH  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Adopted;Algorithms;Area;Awareness;Biological;Biology;Biomedical Research;Black Box;Characteristics;comparative;Computing Methodologies;Data;Data Set;deep learning;design;Disease;Environment;Epidemiology;Genome;genome-wide;Genomics;Genotype;Goals;High Performance Computing;Immunology;improved;interest;Knowledge;Laboratories;Machine Learning;machine learning method;Measurable;Measures;Metagenomics;Methods;microbiome;microbiome analysis;Modernization;multiple data sources;Organism;Phenotype;Phylogenetic Analysis;Phylogeny;Process;Recording of previous events;Research;Sampling;Sequence Alignment;Shapes;Statistical Data Interpretation;statistics;Techniques;Testing;Trees;Update;Work

PROJECT_TITLE: Biology-aware machine learning methods for characterizing microbiome genotype and phenotype

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health;Violence Research

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Interpersonal violence is a leading cause of posttraumatic stress disorder (PTSD), a debilitating syndrome characterized by sleep disturbances, flashbacks, dysregulated emotional reactivity, and increased potential for aggression. Understanding how stress affects the neural circuitry underlying aggression and violence is fundamental to developing effective therapies for treatment or prevention of pathological aggression. These experiments will examine the central amygdala – a brain region involved in both stress and fighting – in the generation of social trauma-induced and stress-related aggression.

PI_NAMEs: NEWMAN, EMILY L (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acute;Adopted;Affect;Aggressive behavior;Amygdaloid structure;behavioral response;Brain;Brain region;Breeding;Calcium;career development;Cells;cellular imaging;Clinical;Complex;Corticotropin-Releasing Hormone;CRH gene;Data;data hub;Decision Making;Deep Brain Stimulation;design;Detection;Development;effective therapy;emotion regulation;Emotional;Ensure;Exhibits;experience;experimental study;Exposure to;Female;fighting;Fright;Future;Generations;Goals;Home;Home environment;Hostility;Hybrids;Image;Impairment;Individual;interpersonal trauma;Interpersonal Violence;Investigation;Link;machine learning algorithm;male;Maps;Mediating;Mediator;Methodology;Modeling;Molecular;Mus;neural;neural circuit;Neurons;Neuropeptides;novel;novel therapeutics;offspring;Operative Surgical Procedures;Optics;optogenetics;Pathologic;Phase;Phenotype;Play;Population;post-doctoral training;Post-Traumatic Stress Disorders;Postdoctoral Fellow;prevent;Prevention;Process;programs;Protocols documentation;Reaction;recruit;Regulation;Research;response;Role;Sensory;sex;Signal Transduction;Sleep disturbances;social;Social Behavior;Social Controls;social defeat;social stress;Specificity;Stress;Stress Tests;stressor;Structure;supervised learning;Synapses;Syndrome;System;theories;Time;Training;translational model;Translational Regulation;Trauma;trauma exposure;Violence;Work

PROJECT_TITLE: Amygdala Circuit Mechanisms for Stress-escalated Aggression


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative (Overall) We and others have recently identified mutations in histone proteins, as well as proteins that mimic oncohistone sequences, in a range of human cancers including brain and mesenchymal tumors. We will determine the effects of newly discovered mutations on the chromatin landscape, the underlying mechanism, and the contexts in which they are relevant to tumorigenesis. Findings of our project will facilitate the development of therapeutics for tumors harboring histone mutations or aberrantly expressing oncohistone mimics.

PI_NAMEs: MUIR, TOM  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Address;Affect;Animal Model;Astrocytoma;ATAC-seq;Bar Codes;big gastrin;Biochemical;Biochemical Genetics;biochemical tools;Biology;Bone neoplasms;Brain Neoplasms;Cancer Model;Cell Culture Techniques;Cell Differentiation process;Cell Fate Control;Cell Line;Cell Physiology;Cells;Chemicals;Chemistry;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Structure;Classification;Clinical;Complex;Data;derepression;design;Development;Diagnosis;DNA methylation profiling;DNA Repair;driver mutation;Enzymes;Ependymoma;Epigenetic Process;epigenome;epigenomics;Frequencies;Future;Gene Expression;gene repression;Genetic;Genetic Screening;Genetic Transcription;Genomic approach;Glioma;Goals;Grant;Histone H3;Histone H3.3;Histones;Human;In Vitro;in vivo;insight;interdisciplinary approach;Investigation;Lead;Libraries;Malignant Neoplasms;Mediating;member;Mesenchymal;Mesenchymal Cell Neoplasm;Modeling;Molecular;mouse model;mutant;Mutation;N-terminal;Nature;novel;Nucleosomes;Oncogenic;oncohistone;overexpression;Pathogenesis;Pathogenicity;Patients;Phenotype;Polycomb;Polymers;Post-Translational Protein Processing;Posterior Fossa;PRC1 Protein;Pre-Clinical Model;Process;programs;Proteins;Proteomics;Recurrence;Role;Sampling;Screening procedure;small molecule inhibitor;Somatic Mutation;Structure;synergism;System;Tail;Testing;theories;Therapeutic;therapeutic development;Trans-Activators;transcriptome sequencing;transcriptomics;Transgenic Organisms;tumor;tumorigenesis;tumorigenic;Work;yeast genetics;Yeasts

PROJECT_TITLE: Role of Histone and Histone-like Mutations in the Oncogenesis of Human Cancers


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

PHR: PROJECT NARRATIVE Discovery of mutations in histone genes (oncohistones) in deadly cancers has uncovered a novel mechanism of oncogenesis with deregulation of normal development at its core. We aim in this project to understand how the H3.3G34 mutations and the new oncohistone-mimic EZHIP act to promote oncogenesis, identify targets amenable to therapy, provide relevant pre-clinical models, and design strategies to optimally engage the immune system to improve survival and provide cure for patients with oncohistone-associated cancers.

PI_NAMEs: JABADO, NADA  (contact)

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;Adopted;Affect;Amino Acid Substitution;Animal Model;base;big gastrin;Biochemical;Bone neoplasms;cancer cell;cancer therapy;Cell Culture Techniques;Cell Line;Childhood Glioma;Chromatin;Classification;Clinical;clinical diagnosis;Codon Nucleotides;Collaborations;Communities;Complement;Coupled;CRISPR/Cas technology;Data;design;Development;Dimensions;Disease;DNA Sequence Alteration;efficacy testing;Elements;Engineering;Ependymoma;epigenetic drug;Epigenetic Process;epigenome;epigenome editing;epigenomics;Exhibits;EZH2 gene;Funding;Genes;Genetically Engineered Mouse;genome-wide;Giant Cell Tumors;Glioma;Goals;H3 K27M mutation;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Histone H3;Histone H3.3;histone methyltransferase;Histones;Human;human disease;immune cell infiltrate;Immune checkpoint inhibitor;Immune system;Immunocompetent;immunogenicity;improved;In Vitro;inhibitor;Innate Immune Response;insight;Joints;Knock-in Mouse;Knowledge;knowledge base;Lead;Lymphocytic Infiltrate;Malignant Neoplasms;Mediating;member;metabolomics;mimicry;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Nature;non-histone protein;novel;Oncogenic;oncohistone;Osteosarcoma;overexpression;Pathogenicity;Patients;Phase;Phenotype;Posterior Fossa;Pre-Clinical Model;programs;Proteins;Regulation;Resources;Role;Sampling;Sarcoma;spatiotemporal;Specificity;stem cell differentiation;Subgroup;success;synergism;System;Tail;Testis;Therapeutic;tissue stem cells;tool;transcriptome;tumor;Tumor Cell Line;tumorigenesis;Validation;Variant;Viral;Xenograft procedure

PROJECT_TITLE: Project 1: Decoding, Modeling and Targeting Oncohistones and an Oncohistone-like Protein


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Food Allergies;Genetics;Human Genome;Prevention

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Eosinophilic esophagitis (EoE) is an allergic disease of the esophagus and has a complex, genetic basis. Though recent research progress suggests that EoE is linked to genetic variants, testing single variants separately does not consider how these variants may be interacting nor how these interactions may bring about or impact disease. This study will evaluate how variants linked to EoE interact and what effects these interactions have on disease features and will develop risk scores based on the biological pathways to predict the chance of developing EoE.

PI_NAMEs: SHODA, TETSUO  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 3-Dimensional;Allergic;Allergic Disease;analytical method;Autoimmune;biobank;Bioinformatics;Biological;Biological Models;Biology;Calpain;Case/Control Studies;cell type;ChIP-seq;Chronic;Clinical;cohort;Collaborations;Complex;CRISPR/Cas technology;Data;Deglutition Disorders;Desmosomes;Disease;disease model;Disease susceptibility;Educational workshop;Eosinophilia;Eosinophilic Esophagitis;Epithelial Cells;Epithelium;Esophageal Diseases;Esophagus;Etiology;Exclusion;exome sequencing;Extracellular Space;Family;Food;Foundations;Functional disorder;Future;Gene Deletion;Gene Frequency;gene interaction;Genes;Genetic;Genetic Predisposition to Disease;Genetic study;genetic variant;Genetic Variation;Genome;genome wide association study;genomic data;Genomics;Heritability;Histologic;Human Genetics;Hyperplasia;Impairment;Inflammatory;innovation;insight;Knowledge;Link;Medical;Medicine;Modeling;Monozygotic twins;multidisciplinary;Multiomic Data;next generation sequencing;novel;Odds Ratio;Organoids;Pain;Pathway interactions;Patients;personalized medicine;Phenotype;Positioning Attribute;Preventive therapy;Process;protein expression;rare condition;rare variant;Research;Research Design;Resources;Risk;risk variant;screening;segregation;Siblings;Single Nucleotide Polymorphism;skill acquisition;stem cells;Testing;transcriptome sequencing;treatment response;TSLP gene;Twin Studies;United States National Institutes of Health;Variant;Vomiting;Widespread Disease

PROJECT_TITLE: Combinatory Effects of Genetic Variants in Eosinophilic Esophagitis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE (ALLIS) Genome-wide sequencing technologies have allowed an unprecedented discovery of somatic mutations in “chromatin and epigenetic modifiers” in human cancers, including high-frequency mutations in histones, the proteins charged with packaging our genome. The proposed research will determine how newly identified cancer-associated histone mutations disrupt epigenetic landscapes and lead to cancer. These findings are expected to pave new avenues for the development of cancer therapeutics in tumors harboring histone mutations.

PI_NAMEs: YOUNG, MICHAEL WARREN (contact)

PROJECT_TERMS: Affect;Alleles;Allografting;Animal Model;ATAC-seq;Bar Codes;Biological Assay;Biology;Cancer Biology;cancer cell;Cancer cell line;cancer type;Cell Differentiation process;Cell Fate Control;Cell Line;Cell Physiology;cell type;Cells;Cellular Structures;cellular transduction;Characteristics;Charge;Chemicals;Childhood Glioma;ChIP-seq;Chondroblastoma;Chromatin;Chromatin Structure;Collaborations;Complementary DNA;Cues;Data;Defect;design;Development;DNA;DNA Damage;DNA methylation profiling;DNA Modification Process;DNA Repair;driver mutation;Epigenetic Process;epigenome;Frequencies;gain of function;Gene Expression;Genetic;Genetic Screening;Genetic Transcription;Genome;genome-wide;Goals;Grant;Growth;Histone H3;histone methyltransferase;histone modification;Histones;Human;in vivo;inducible Cre;insight;interdisciplinary approach;Knock-in;Laboratories;Lead;Libraries;Link;Lysine;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Mesenchymal Stem Cells;Methionine;Missense Mutation;Modeling;Modification;Molecular;mouse model;multidisciplinary;Mus;Mutate;Mutation;N-terminal;novel;Nucleosomes;Oncogenic;oncohistone;Pathologic;Pathway interactions;Patients;pharmacologic;Phenotype;Play;Positioning Attribute;Post-Translational Protein Processing;Pre-Clinical Model;prevent;Process;programs;Property;Proteins;Reader;Recurrence;Research;Research Personnel;response;Role;Sarcoma;self-renewal;Site;small molecule;small molecule inhibitor;Somatic Mutation;success;Tail;Technology;Testing;Therapeutic;transcriptome sequencing;transcriptomics;Translating;translational approach;Transplantation;tumor;Tumor Subtype;tumorigenesis;tumorigenic;Undifferentiated;Variant;Work;Writing;Xenograft procedure

PROJECT_TITLE: Project 2: Elucidating Mechanisms of Chromatin Dysregulation by Oncohistones


PHR: PROJECT NARRATIVE The broad goal of this project is to use high-throughput screening tools to profile a newly identified collection of cancer-associated histone mutations, thereby guiding subsequent mechanistic investigations into how select mutations alter chromatin structure and state.

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;Alleles;Architecture;Bar Codes;Biochemical;Biochemical Genetics;Biochemical Process;Biological;Biology;biophysical properties;Biophysics;cancer cell;cancer type;Categories;Cell Culture System;Cell Survival;Chemicals;Chemistry;Chromatin;chromatin remodeling;Chromatin Structure;Collaborations;Collection;Data;Databases;Deposition;design;dimer;Disease;DNA;Epigenetic Process;epigenetic regulation;Excision;falls;Funding;Future;Genes;Genetic Screening;Genetic Transcription;Genome;genome integrity;Genomic approach;Genomic DNA;Genomics;Globular Region;Goals;high throughput screening;Histone Fold;Histone H3;Histones;Human;in vivo evaluation;Investigation;knowledge base;Lead;Libraries;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;member;Methods;Methyltransferase;Missense Mutation;Modification;Molecular;mouse model;mutant;Mutation;N-terminal;Nucleosomes;oncohistone;Output;permissiveness;Phase;Phenotype;Physiological;Polymers;Post-Translational Protein Processing;Process;programs;Proteins;Proteomics;Role;screening;Screening procedure;Screening Result;Signal Transduction;Structure;success;Tail;Technology;Testing;Therapeutic;tool;Trans-Activators;Transcriptional Regulation;tumor;tumorigenesis;Validation;Work;yeast genetics;Yeasts

PROJECT_TITLE: Project 3: Mechanisms of Methyltransferase Dysregulation by Oncohistones


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases

PHR: PROJECT NARRATIVE: In this project, we aim to define how misregulation of histone H3K36 methylation by oncohistones promotes tumorigenesis. Specifically, our study will provide new insights into the role of H3K36-directed methyltransferases and the H3.3 G34 and H3 K36M oncohistones in cancer biology. Results from our studies will provide new insights into molecular targets for disease diagnosis and advance therapeutic intervention.

PI_NAMEs: LEWIS, PETER W (contact)

PROJECT_TERMS: Affect;Animals;Astrocytoma;big gastrin;Binding;Biochemical;Biochemistry;Biological Assay;Bone neoplasms;Brain Stem Glioma;Cancer Biology;Cancer Model;Cell Differentiation process;Cell Proliferation;Cells;Chemistry;Chondroblastoma;Chromatin;chromatin modification;Clinical;Complex;CpG Islands;CRISPR/Cas technology;derepression;design;Development;Diagnostic;Diffuse;diffuse midline glioma;disease diagnosis;DNA Methylation;effective therapy;Elements;Enhancers;Enzymes;Ependymoma;Epigenetic Process;EZH2 gene;Foundations;Frequencies;Gene Expression;gene repression;Gene Silencing;Genes;Genetic Screening;genome-wide;Genomics;Giant cell tumor of bone;Glioma;Goals;Health;Histone H3;histone methylation;Histones;Human;In Vitro;in vivo;innovation;insight;interdisciplinary approach;Investigation;Kinetics;Lead;Malignant - descriptor;Malignant Neoplasms;Mediating;member;Methods;Methylation;Methyltransferase;Modeling;Molecular;Molecular Chaperones;Molecular Target;mutant;Mutation;novel;oncohistone;Pathogenicity;Pathway interactions;Patients;Phenotype;Polycomb;Positioning Attribute;Post-Translational Protein Processing;Post-Translational Regulation;Posterior Fossa;PRC1 Protein;prevent;programs;recruit;Regulation;Role;Sampling;Sarcoma;sensor;Squamous cell carcinoma;Structure-Activity Relationship;Surface;System;Testing;theories;Therapeutic;therapeutic development;Therapeutic Intervention;Toxic effect;Transcript;tumor;tumorigenesis;tumorigenic;Undifferentiated;Work

PROJECT_TITLE: PROJECT 4: ELUCIDATING MECHANISMS OF HISTONE H3K36 DYSREGULATION BY ONCOHISTONES


NIH_SPENDING_CATS: Cancer;Genetics

PROJECT_TERMS: Administrative Personnel;Administrator;Attention;Budgets;career development;Collaborations;Communication;Communities;data sharing;Ensure;experience;General Population;Histones;Human;Institution;Laboratories;Location;Maintenance;Malignant Neoplasms;meetings;Mutation;Occupational activity of managing finances;Office of Administrative Management;Postdoctoral Fellow;Program Development;programs;Progress Reports;Records;Reporting;Research;research and development;Research Personnel;Role;Safety Management;Schedule;Science;Scientist;Students;synergism;tumorigenesis;Universities;Update;web site;Workplace


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE (MAJEWSKI) Cancer progression is associated with massive global aberrations of genome and epigenome organization. Modern genomics technologies have provided invaluable new insights into molecular mechanisms of cancers, including the discovery by our team members of the histone mutations that are the subject of this proposal. The establishment of this Core will provide team members with state of the art genomic and computational tools to unravel the mechanisms of action of histone mutations.

PI_NAMEs: MAJEWSKI, JACEK  (contact)

PROJECT_TERMS: Antibodies;ATAC-seq;Bioinformatics;Biological Assay;Cells;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;Collaborations;comparative;computerized data processing;computerized tools;Computing Methodologies;Data;Detection;DNA;DNA Methylation;Emerging Technologies;Epigenetic Process;epigenome;epigenomics;functional genomics;Gene Expression;Generations;Genes;Genome;genome-wide;Genomic approach;genomic data;genomic tools;Genomics;histone modification;Histones;Human;improved;insight;interest;Malignant Neoplasms;Maps;Mediating;member;Methods;Modernization;Modification;Molecular;Molecular Conformation;Mutation;nanopore;Neoplastic Cell Transformation;novel;Phenotype;Production;Publications;Quality Control;Quebec;Resource Sharing;RNA;Role;secondary outcome;Side;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;success;Techniques;Technology;tool;Transcription Initiation Site;transcriptome;transcriptome sequencing;tumor progression;tumorigenesis;Universities;Variant;Work

PROJECT_TITLE: Shared Resources Core 1:  Genomics/Epigenomics Core


PHR: Project Narrative Mutations to several epigenetic related genes have been discovered across several classes of human cancers. This research will help define altered chromatin and signaling pathways due to these gene mutations, which will inform mechanisms and potential design of therapeutics for treatment of human cancers.

PI_NAMEs: GARCIA, BENJAMIN A (contact)

PROJECT_TERMS: Affect;Antibodies;Biochemical;Biology;Cell Line;Cells;Chromatin;Chromatin Structure;Chromatography;combinatorial;Communities;Computing Methodologies;design;Enhancement Technology;Enzymes;Epigenetic Process;Epitopes;experimental study;Formalin;Gene Expression Profile;Gene Mutation;Genes;Goals;histone modification;Histones;Human;human disease;improved;In Vitro;in vivo;Injections;Isotope Labeling;Isotopes;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Measurement;member;Methods;Modeling;Modification;Mutation;nano;new technology;next generation;non-histone protein;novel;Oncogenic;oncohistone;Paraffin Embedding;Pennsylvania;polypeptide;Post Translational Modification Analysis;Post-Translational Modification Site;Post-Translational Protein Processing;Process;Program Research Project Grants;programs;Protein Analysis;Protein Conformation;protein expression;protein protein interaction;Proteins;Proteome;Proteomics;Research;Research Personnel;Resource Sharing;Role;sample archive;Sampling;Signal Pathway;Signaling Protein;sortase;structural biology;Structure;Techniques;Technology;technology development;Therapeutic;Time;Tissues;tumor;Tumor Tissue;tumorigenesis;Universities;Work

PROJECT_TITLE: Shared Resources Core 2: Quantitative Proteomics Core


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Substance Misuse

ORG_CITY: LOUISVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PUBLIC HEALTH RELEVANCE The proposed research is relevant to public health because the insights gained by the accomplishments of the proposed studies will help in elucidating the molecular mechanisms underlying ethanol-induced birth defects and characterizing a novel, exosome-mediated intercellular interaction between neural crest cells and placodes during ethanol-induced teratogenesis. These studies are expected to establish the administration of edible plant-derived exosome-like nanoparticles as a novel strategy for the prevention of human FASD. Thus, the proposed research is relevant to the NIAAA's mission that pertains to using the knowledge gained in uncovering target sites for alcohol's action on the embryonic and fetal stages of life to begin developing potential therapeutic or preventative interventions.

PI_NAMEs: CHEN, SHAO-YU  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Address;Affect;alcohol effect;alcohol exposure;Alcohols;Cells;Cephalic;Congenital Abnormality;Cranial Nerves;craniofacial;Craniofacial Abnormalities;CRISPR/Cas technology;CXCR4 gene;Data;Defect;Distant;Edible Plants;Embryo;Ethanol;exosome;fetal;Fetal Alcohol Spectrum Disorder;Grapes;Human;In Vitro;in vivo;innovation;insight;intercellular communication;Knowledge;Laboratories;Life;Mediating;Mental Retardation;microRNA delivery;MicroRNAs;migration;Mission;Modeling;Molecular;nanoparticle;National Institute on Alcohol Abuse and Alcoholism;Neural Crest Cell;novel;novel strategies;novel therapeutic intervention;Pathogenesis;Plants;prevent;Prevention;Prevention strategy;preventive intervention;Public Health;public health relevance;Regulation;Repression;Research;Role;sensory system;Signal Transduction;Site;Skeleton;Stromal Cell-Derived Factor 1;teratogenesis;Testing;Therapeutic;Therapeutic Intervention;transcriptome sequencing;translational potential;Work;Zebrafish

PROJECT_TITLE: Role of exosomes in the coordinated migration of neural crest cells and placodes and ethanol-induced teratogenesis


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Precision Medicine

ORG_CITY: HONOLULU

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: LAY SUMMARY Diet and nutrition have well-recognized significance in human development and health, and diseases, particularly the common chronic diseases, such as obesity, cancer, cardiovascular disease, and diabetes mellitus, but the underlying molecular and biochemical mechanisms are often unknown, which hinder the development of effective and specific interventions. Furthermore, these chronic and life-threatening diseases also show remarkable disparities in diverse populations, including the underrepresented and underserved groups, highlighting the urgent need for employing novel approaches such as precision nutrition analyses empowered by artificial intelligence and machine learning for growing data sources. This training program will produce doctoral scientists with cross-disciplinary breadth and knowledge in artificial intelligence for precision nutrition science research as the innovators and leaders to improve nutrition health and prevent and treat nutrition-related chronic diseases, with special attention to the unique populations found in Hawaii.

PI_NAMEs: DENG, YOUPING  (contact);NOVOTNY, RACHEL

PROGRAM_OFFICER_NAME: RAVICHANDRAN, VEERASAMY

PROJECT_TERMS: Artificial Intelligence;Hawaii;Nutritional Science;precision nutrition;Research;Training

PROJECT_TITLE: The Hawaii Advanced Training in Artificial Intelligence for Precision Nutrition Science Research (AIPrN)


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE  Evidence supports tailoring cancer screening to each individual’s risk. We propose to enhance and disseminate software that scans electronic health records of target patient populations to (i) automatically identify those who may benefit from genetic testing for hereditary cancers according to national cancer guidelines; and (ii) use automated “chatbots” for patient outreach offering patient education and the opportunity to receive at-home genetic testing for hereditary cancers. Through wide dissemination, our software platform has the potential to reduce cancer burden by enabling evidence-based cancer screening tailored to the individual.

PI_NAMEs: DEL FIOL, GUILHERME  (contact);KAWAMOTO, KENSAKU

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Academic Medical Centers;Address;Adoption;Advanced Malignant Neoplasm;Algorithms;anti-cancer research;budget impact;Cancer Burden;Cancer Center;cancer genetics;cancer prevention;Cancer Research Project;cancer risk;chatbot;Clinical;clinical decision support;Clinical effectiveness;cloud based;Collaborations;Colorectal Cancer;Complex;Computer software;Cost Analysis;Coupled;Data;detector;Disparity;Education;Electronic Health Record;electronic health record system;Eligibility Determination;evidence base;experience;Family;Fast Healthcare Interoperability Resources;Funding;Genetic;genetic analysis;Genetic Counseling;Genetic Enhancement;genetic testing;Goals;Guidelines;Health;health disparity;health equity promotion;Health Expenditures;Health system;Healthcare Systems;Hereditary Malignant Neoplasm;high risk;high risk population;Home;Hospitals;implementation barriers;implementation evaluation;implementation framework;Implementation readiness;implementation strategy;implementation tool;Individual;Informatics;informatics tool;Infrastructure;interoperability;Intervention;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;marginalized population;Marketing;Medical;Medical center;Medicine;meetings;Morbidity - disease rate;mortality;National Cancer Institute;National Comprehensive Cancer Network;New York;novel;novel strategies;open source;Patient Education;patient outreach;patient population;Patients;personalized approach;Phase;Population;population based;precision medicine;Prevention Research;Primary Care;primary care clinic;primary care setting;Process;programs;Public Health;Randomized;Recording of previous events;Research;Research Personnel;Research Training;Resource-limited setting;Resources;Risk;Risk Assessment;Risk Factors;Risk Management;risk stratification;safety net;Scanning;Science;screening;Screening for cancer;Services;Site;South Carolina;support tools;Technology;Test Result;Testing;Universities;Utah;Variant;Workload

PROJECT_TITLE: GARDE: Scalable Clinical Decision Support for Individualized Cancer Risk Management


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative A comparative effectiveness study of buprenorphine vs. methadone vs. morphine for the pharmacological treatment of Neonatal Opioid Withdrawal Syndrome (NOWS). Outcome measures include: length of hospital stay, length of pharmacological treatment and neurodevelopmental outcomes up to 24 months of age. Identifying the optimal treatment can shorten the time of maternal-newborn separation, decrease the costs of treatment for NOWS and ensure that the chosen medication does not have adverse developmental outcomes compared to other medication options.

PI_NAMEs: LEEMAN, LAWRENCE M (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Admission activity;Age Months;American Indian Women;Assessment tool;Buprenorphine;Caring;clinical center;clinically relevant;Collaborations;comparative effectiveness;comparative effectiveness study;comparative effectiveness trial;design;Development;Dose;Drug Exposure;Ensure;Evaluation;experience;follow-up;Growth;Health Benefit;Helping to End Addiction Long-term;Hospitals;improved;Infant;Institution;Latinx;Length;Length of Stay;maternal opioid use;Methadone;Methamphetamine;Mexican;Morphine;Mothers;multi-ethnic;Neonatal;Neonatal Abstinence Syndrome;neonatal care;Neonatal Intensive Care Units;neonate;neurodevelopment;New Mexico;Newborn Infant;non-opioid analgesic;Nonpharmacologic Therapy;Nursing Research;opioid epidemic;opioid use;opioid use disorder;optimal treatments;Outcome;Outcome Measure;Perinatal;Pharmaceutical Preparations;Pharmacological Treatment;polysubstance use;Population;Principal Investigator;Protocols documentation;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Regimen;Research;Research Personnel;Research Subjects;Selective Serotonin Reuptake Inhibitor;Series;Site;Standardization;study population;Time;Tobacco;Tobacco use;Toddler;Treatment Cost;Universities;Weaning

PROJECT_TITLE: HEAL Initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial New Mexico Site


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: FOX LEARNING SYSTEMS, INC.

PHR: Postpartum depression can be prevented by the Reach Out, Stay Strong, Essentials for mothers of newborns (ROSE) evidence-based program yet continues to affect nearly 600,000 women and their families annually. Our goal is to help reduce rates of PPD by finishing development of a full app-based ROSE program (e-ROSE), evaluate the app’s outcomes for depression and return on investment, and determine if satisfaction and perceived access mediate outcomes. At the end of the project, the e-ROSE product will be ready for commercialization nationwide, allowing for easy, low-cost distribution on a variety of platforms to end-users, and we will have laid the groundwork for further research on implementation.

PI_NAMEs: FOX, DEBRA L (contact);POLESHUCK, ELLEN L

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Affect;Child;Clinical Trials;commercialization;commercialization readiness;Computers;Control Groups;cost;Data;depression prevention;design;Development;Diagnosis;Education;Effectiveness;efficacy evaluation;Electronic Health Record;emotional distress;evidence base;Evidence based program;experience;Family;Family Relationship;Feedback;Financial Hardship;Goals;health care service utilization;Health Insurance;Health Personnel;High Risk Woman;implementation cost;implementation study;improved;Incidence;Individual;Industry;Infant Development;Intervention;Interview;Investments;Lived experience;Low income;Measures;Mediating;Mediator;Medicaid;Mental Depression;Mothers;Nature;neuropsychiatry;Newborn Infant;Outcome;Pamphlets;Pathway interactions;Persons;Phase;Positioning Attribute;Postpartum Depression;Postpartum Period;Pregnant Women;prevent;preventive intervention;Production;programs;prototype;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Research;satisfaction;Schedule;Series;Testing;Third Pregnancy Trimester;Time;Training;United States Preventative Services Task Force;uptake;virtual;virtual group;Woman;Women's Group

PROJECT_TITLE: Development and Randomized Clinical Trial of an App-based Intervention to Reduce Postpartum Depression in High-Risk Women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-D(16)]


ORG_CITY: DURHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Epilepsy arising from the temporal lobes is a major public health problem for which there is only symptomatic therapeutics. Developing preventive and disease modifying therapies for human epilepsy is a glaring unmet medical need. This proposed study is to identify novel small molecule inhibitors for inhibiting the signaling pathway required for development of temporal lobe epilepsy.

PI_NAMEs: MCNAMARA, JAMES O. (contact)

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: Adult;Anticonvulsants;anxiety-like behavior;aqueous;Autoimmune;Behavior assessment;Benchmarking;Binding Proteins;Biological Assay;Biological Markers;Brain;brief intervention;Cells;Central Nervous System Diseases;Cessation of life;chemical genetics;Clinical Research;comorbidity;design;Development;Disadvantaged;Disease;Dose;drug discovery;Drug Kinetics;drug modification;efficacy evaluation;Epilepsy;Epileptogenesis;Exhibits;experimental study;genetic approach;Goals;Human;improved;In Vitro;in vivo;inhibitor;innovation;insight;Lead;lead series;Measures;Mediating;Medical;Mission;Modeling;Molecular;Molecular Target;molecular targeted therapies;Mus;National Institute of Neurological Disorders and Stroke;Nervous System;Neuronal Injury;neuroprotection;Neurotrophic Tyrosine Kinase Receptor Type 2;novel;Pathway interactions;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phase;Phosphotransferases;Plasma;PLC gamma1;preclinical study;prevent;Preventive;programs;Property;Proteins;Public Health;Pyrimidinones;Receptor Protein-Tyrosine Kinases;Recurrence;Sampling;Seizures;Series;Signal Pathway;Signal Transduction;small molecule inhibitor;Solubility;Status Epilepticus;symptom treatment;Temporal Lobe;Temporal Lobe Epilepsy;Testing;Therapeutic;Thiourea;Time;Validation;Work

PROJECT_TITLE: Small molecule inhibitors of TrkB Signaling

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE A significant portion of adult patients with depression exhibit increased inflammation, which has been associated with impaired corticostriatal reward circuitry and symptoms of anhedonia. Preclinical and clinical evidence from our group and others demonstrates that inflammation impacts corticostriatal circuitry by decreasing the availability and release of dopamine. The current proposal builds upon our prior work and aims to develop potential new treatment interventions for adult patients with depression and high inflammation by targeting reward circuitry and anhedonia through the use of a dopaminergic therapy.

PI_NAMEs: FELGER, JENNIFER C (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Acute;Adult;Affect;Anhedonia;Anisotropy;anti-depressive agents;Behavior;Behavioral;Biological;Biological Availability;Biological Markers;Brain;C-reactive protein;Central Nervous System;Clinical;Corpus striatum structure;Cross-Over Studies;cytokine;Data;density;depressed patient;depressive symptoms;Disease;Disease remission;DOPA decarboxylase;Dopamine;Dose;Double-Blind Method;DSM-V;Exhibits;Functional impairment;Functional Magnetic Resonance Imaging;Gene Expression;Hamilton Rating Scale for Depression;imaging biomarker;Impairment;improved;indexing;Inflammation;Inflammatory;inflammatory marker;Intervention;inventory of depressive symptomatology;Levodopa;Link;Magnetic Resonance Imaging;Major Depressive Disorder;Measures;Medical;meetings;Mental Depression;Motivation;novel strategies;Outcome;Pathway interactions;patient population;Patient Self-Report;Patients;peripheral blood;personalized medicine;Pharmaceutical Preparations;pharmacologic;Phase;Placebo Control;Placebos;Plasma;pre-clinical;predicting response;Prefrontal Cortex;Prevalence;Psychomotor Performance;Public Health;Randomized;receptor;Reporting;Residual state;Resistance;response;Rest;reward circuitry;Rewards;Role;Safety;Severities;Speed;Subgroup;Symptoms;Testing;Time;treatment strategy;Ventral Striatum;Visit;white matter;Work

PROJECT_TITLE: Dopaminergic Therapy for Inflammation-Related Anhedonia in Depression


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Transplantation

ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE APOL1 genetic variations have been shown to explain in part the increased risk of African Americans compared to non-African American for end-stage kidney disease. However, the association of APOL1 high risk alleles with kidney transplant outcomes such as change of kidney function, acute rejection and graft failure is unclear. We propose to determine if the presence of APOL1 risk alleles in donor and recipients is associated with recipient kidney transplant outcomes as well as determine the impact of kidney donation for individuals with APOL1 risk alleles.

PI_NAMEs: ROSAS, SYLVIA E (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acceleration;Acute;Address;African American;African American population;African ancestry;Albumins;Alleles;Allografting;American;Antibodies;APOL1 gene;Apolipoproteins;Arizona;Bacterial Infections;Basic Science;Biological Specimen Banks;Biopsy;Blood;Chronic;Chronic Kidney Failure;Clinic;clinical center;Clinical Data;Clinical Research;cohort;Consent;Cost Savings;Counseling;Creatinine;Data;data repository;Deterioration;Diabetes Mellitus;Diagnostic;digital pathology;Disparity;DNA;Donor person;Education;Eligibility Determination;End stage renal failure;Enrollment;Ensure;Environmental Risk Factor;ethnic difference;European;Evaluation;experience;Face;Failure;follow-up;Future;gene interaction;General Hospitals;Genes;Genetic;genetic risk factor;Genetic Variation;Genotype;Geography;graft failure;Graft Survival;Hand;Health;Health Care Costs;high risk;HLA Antigens;Hospitals;Immunosuppression;improved;Individual;Infrastructure;Interdisciplinary Study;Israel;Kidney;kidney biopsy;Kidney Failure;Kidney Transplantation;Lesion;Living Donors;living kidney donor;Longterm Follow-up;Massachusetts;Measures;Medical;Medical center;novel;Organ;Outcome;Participant;Patients;Pattern;Phase;Phenotype;Policies;policy implication;post-transplant;Prevalence;primary outcome;prognostic;programs;prospective;Proteinuria;protocol development;Public Health;Quality of life;racial difference;recruit;Recurrent disease;Registries;Renal function;Renal Replacement Therapy;Reporting;repository;Research;Resources;Risk;risk variant;RNA;Role;Safety;Science;secondary outcome;Serum;Site;Slide;Therapeutic;Time;Translational Research;Transplant Recipients;Transplantation;United Network for Organ Sharing;United States National Institutes of Health;Universities;Urine;Variant;Virginia;Virus Diseases;Woman

PROJECT_TITLE: 9/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center


ORG_DEPT: SURGERY

PHR: Overall NARRATIVE The Houston Center for Acquired Resistance Research (H-CARR) will act as the organizing entity for a multi- institutional, multi-disciplinary effort to detect acquired cisplatin resistance early in development and generate molecular and metabolic strategies for overcoming it. Investigators from Baylor College of Medicine and the University of Texas MD Anderson Cancer Center will investigate interactions between cancer cells, infiltrating immunocytes and neurons to both understand the critical drivers of cisplatin resistance in head and neck squamous cell carcinoma and develop precision oncology approaches to its clinical utilization in this deadly cancer and other similar solid tumors.

PI_NAMEs: MYERS, JEFFREY NICHOLAS (contact);SANDULACHE, VLAD C

PROJECT_TERMS: Acute;Adrenergic Agents;afferent nerve;Algorithms;Amino Acids;Biological;Biological Markers;Biomass;cancer cell;Cancer Etiology;cancer imaging;cancer survival;Carbon;Cessation of life;Cetuximab;chemotherapeutic agent;chemotherapy;Chronic;Cisplatin;Citric Acid Cycle;Clinical;clinical application;clinical practice;Clinical Trials;college;Data;Dependence;design;Development;Distant Metastasis;early detection biomarkers;experimental study;Extinction;FADH2;Generations;Genomics;Genotoxic Stress;Glutathione;Glycolysis;Goals;GPX2 gene;Head and Neck Squamous Cell Carcinoma;Human;Human Papillomavirus;Image;imaging study;Immune checkpoint inhibitor;immunogenic;improved;Individual;individual patient;Infiltration;Infrastructure;insight;Institution;Invaded;Link;Magnetic Resonance Imaging;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant Neoplasms;Medicine;Metabolic;metabolic imaging;Metabolic stress;metabolomics;Modality;Modeling;Molecular;multidisciplinary;Mutation;Neoadjuvant Therapy;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Neurons;non-invasive imaging;novel;Paracrine Communication;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Pre-Clinical Model;precision oncology;prevent;Production;prospective;Pyruvate;Regimen;Research;Research Personnel;Resistance;Resistance development;response;Role;Signal Transduction;Solid Neoplasm;standard of care;Stress;targeted agent;Technical Expertise;Testing;Time;TP53 gene;transcriptomics;translational potential;tumor;Tumor Biology;Tumor Immunity;tumor metabolism;tumor-immune system interactions;University of Texas M D Anderson Cancer Center;Upper aerodigestive tract cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative: Human papillomaviruses (HPVs) are important human viral pathogens responsible for cervical cancer and more than 70% of head, neck, and throat cancers (HNT), which are on the rise, especially in a younger group of non- smoking men aged 40s and 50s. There are no effective treatments for HPV infection and the subsequent potential for malignant transformation has a serious effect on public health. This proposal is aimed at understanding HPV-host interactions that represents a significant gap in knowledge that is critical to drive research into improved health care of HPV-infected patients and improved vaccine design.

PI_NAMEs: HAFENSTEIN, SUSAN  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;Affect;Affinity;aged;Antibodies;Antibody Response;Antibody-mediated protection;Basal Cell;Binding;Capsid;Capsid Proteins;Cells;Cervical;Characteristics;Collaborations;Communities;Computers;Cryoelectron Microscopy;design;effective therapy;Epitopes;Genome;Head and Neck Cancer;Head Cancer;Healthcare;Human;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Immune;Immune response;Immunologics;improved;Infection;Knowledge;L2 viral capsid protein;Life Cycle Stages;Link;Location;Malignant - descriptor;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;men;Minor;Molecular;Molecular Biology;Molecular Conformation;Monoclonal Antibodies;Neck Cancer;non-smoking;novel therapeutics;particle;pathogenic virus;Patients;Persons;Pharmaceutical Preparations;Process;Production;Proteins;Public Health;receptor;Research;Research Personnel;Resolution;response;Scheme;Shapes;stoichiometry;Structural Protein;Structure;System;Techniques;three dimensional structure;Throat Cancer;Time;Vaccine Design;vaccine development;Vaccines;Virus;Virus-like particle

PROJECT_TITLE: Structural Studies of Human Papillomavirus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Y(03)M]


NIH_SPENDING_CATS: Cancer

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PI_NAMEs: MYERS, JEFFREY NICHOLAS (contact)

PROJECT_TERMS: Administrative Coordination;Administrator;Advisory Committees;Affect;Agreement;Basic Science;Bioinformatics;Biological Specimen Banks;Cisplatin;Clinical Research;Collaborations;Communication;Communities;Consult;Consultations;cost effective;Data Coordinating Center;data integrity;data management;data quality;Decision Making;Dedications;design;Discipline;Drug resistance;Employment;Ensure;Equilibrium;Event;experience;Future;Goals;Grant;Head and Neck Cancer;Human Resources;Institution;interdisciplinary approach;Leadership;lectures;meetings;Modeling;Monitor;multidisciplinary;Outcome;Performance;Periodicals;Pharmacotherapy;pre-clinical;pre-clinical research;Preparation;Publications;Qualifying;quality assurance;Quality Control;Recommendation;Regulation;Reporting;Research;Research Activity;Research Infrastructure;Research Personnel;Resistance;Resources;Rest;Schedule;Structure;success;symposium;System;Training;Translational Research;tumor;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Rare Diseases

PI_NAMEs: COARFA, CRISTIAN  (contact)

PROJECT_TERMS: advanced analytics;Advisory Committees;ATAC-seq;Big Data;Bioinformatics;Biological Markers;Cell Line;ChIP-seq;Cisplatin;Code;Collaborations;Communities;complex data;Consult;Data;data acquisition;Data Analyses;data dissemination;data integration;data pipeline;Data Set;data sharing;data streams;design;Development;Drug resistance;Ensure;Funding Agency;Generations;Genomics;Head and Neck Squamous Cell Carcinoma;Human;human data;Individual;Institution;metabolic imaging;metabolomics;Metadata;Methodology;mid-career faculty;Modeling;Molecular and Cellular Biology;Multiomic Data;multiple omics;Neoplasm Circulating Cells;open source;Policies;prevent;Process;programs;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;Resistance;Resistance development;response;sharing platform;single-cell RNA sequencing;Site;Solid Neoplasm;Source Code;success;synergism;System;Technology;Time;transcriptomics;United States National Institutes of Health;University of Texas M D Anderson Cancer Center;Visualization;Work

PROJECT_TITLE: Systems Bioinformatics Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Rare Diseases

PI_NAMEs: EL-NAGGAR, ADEL K. (contact)

PROJECT_TERMS: Animal Model;Biological Markers;Biological Specimen Banks;Blood;Cancer cell line;Cell Line;Cell Maintenance;Clinical;Collaborations;Collection;college;cytokine;Cytology;Database Management Systems;Databases;Development;Diagnosis;Drug or chemical Tissue Distribution;Ensure;Evaluation;Fine needle aspiration biopsy;Fostering;Genomics;Guidelines;Harvest;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Health Insurance Portability and Accountability Act;Human Resources;Immunohistochemistry;immunosuppressed;Individual;innovation;Laboratories;Lead;Leadership;Link;Malignant - descriptor;Medicine;Modeling;Mus;Nucleic Acids;Pathologic;Pathology;patient derived xenograft model;Patients;peripheral blood;Preparation;Process;programs;repository;Research;Research Personnel;Resistance;Resources;Sampling;Secure;Services;Specimen;Techniques;Tissue Banks;Tissue Microarray;Tissue Sample;Tissues;tumor;United States National Institutes of Health;University of Texas M D Anderson Cancer Center;Western Blotting

PROJECT_TITLE: Tumor Model and Biospecimen Repository Core


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Immunotherapy;Rare Diseases

PI_NAMEs: SANDULACHE, VLAD C (contact)

PROJECT_TERMS: Ablation;Aggressive behavior;amino acid metabolism;Amino Acids;Anabolism;Automobile Driving;Biological Markers;cancer type;Carbon;Catabolism;Cell Line;Cell Survival;Cells;Chemicals;chemokine;chemotherapy;Cisplatin;Clinic;Clinical;Coupled;cytokine;cytotoxic;Data;defined contribution;design;Development;disorder control;Effectiveness;Enzymes;Equilibrium;experimental study;FADH2;Generations;Genetic Transcription;Genomics;Genotoxic Stress;Glucose;Glutamine;Glutathione;GPX2 gene;Head and Neck Squamous Cell Carcinoma;Human;Image;Immune;Immune checkpoint inhibitor;Immunocompetent;Immunologic Surveillance;Immunologics;immunoregulation;In Vitro;in vivo;Incidence;Individual;knock-down;Link;Lung;Malignant Neoplasms;Measurement;Measures;Mediating;Metabolic;Metabolism;Mitochondria;Modeling;Molecular Target;mouse model;Myeloid-derived suppressor cells;Natural regeneration;neoplastic cell;NF-kappa B;overexpression;Paracrine Communication;Pathway interactions;patient biomarkers;patient response;Patients;permissiveness;Peroxidases;Peroxides;personalized approach;Phenotype;Platinum;Platinum Compounds;Population;Pre-Clinical Model;Production;Prostaglandin Production;Prostaglandins;rapid detection;Research;Resistance;Resistance development;response;Role;Signal Transduction;small hairpin RNA;Solid Neoplasm;Stress;Testing;therapy resistant;Time;Treatment Failure;treatment response;tumor;tumor behavior;tumor growth;Tumor Immunity;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Work

PROJECT_TITLE: Metabolic adaptation enables cisplatin resistance and inhibits tumor immunity


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Rare Diseases

PI_NAMEs: OSMAN, ABDULLAH ALI (contact)

PROJECT_TERMS: Adrenergic Agents;afferent nerve;Afferent Neurons;Agreement;Biological Markers;Cell Line;Cells;Chemoresistance;chemotherapy;Cisplatin;Clinical;clinical biomarkers;Clinical Data;cohort;Complex;CRISPR library;Data;Data Correlations;defined contribution;Development;Disease;Distant Metastasis;DNA Sequence Alteration;Drug Targeting;Event;Fostering;functional status;Gene Expression;Genetic Transcription;Genomics;Glutaminase;Glutathione;Head and Neck Squamous Cell Carcinoma;HPV positive;Human;Human Papillomavirus;Immunotherapy;improved;in silico;Incidence;inhibitor;Invaded;knock-down;Knowledge;Laboratories;Link;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant Neoplasms;Metabolic;Metabolism;MicroRNAs;Modeling;Molecular;Molecular Profiling;mortality;Mus;Mutation;mutational status;Neoplasm Metastasis;neoplastic cell;neural;neurogenesis;Neurons;Normal tissue morphology;novel;novel therapeutics;oral HPV-positive head and neck cancers;paracrine;Paracrine Communication;Pathway interactions;Patients;perineural;permissiveness;Pharmaceutical Preparations;pharmacologic;phase II trial;Phenotype;pre-clinical;Pre-Clinical Model;prevent;Prognosis;Publications;Recurrence;Reproducibility;Research;Resistance;response;Role;Signal Transduction;Solid Neoplasm;Somatic Mutation;Testing;Therapeutic;Tongue Neoplasms;Toxic effect;TP53 gene;Transcriptional Regulation;Treatment Failure;tumor;tumor behavior;tumor microenvironment;tumor progression;Upper aerodigestive tract cancer

PROJECT_TITLE: Defining the role of KEAP/NRF2 signaling dysregulation and sensory nerve reprograming during acquisition of cisplatin resistance and metastasis in HNSCC


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Rare Diseases

PI_NAMEs: LAI, STEPHEN Y (contact)

PROJECT_TERMS: Aerodigestive Tract;Algorithms;Biochemical;Biological;Biological Assay;Biological Markers;Biological Models;biomarker identification;Biopsy Specimen;Blood specimen;Carbon;Cell Line;Cells;Characteristics;Chemicals;chemoradiation;chemotherapy;Cisplatin;Clinical;clinical decision-making;Clinical Trials;Coenzymes;Coupled;Data;design;Detection;Development;Diagnostic Neoplasm Staging;Disease;Dose;drug testing;Early Diagnosis;effective therapy;Effectiveness;Evaluation;Exposure to;Failure;Feedback;Genomics;Genotoxic Stress;Glycolysis;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Human;Image;imaging approach;In Vitro;in vitro Assay;in vivo;Knowledge;Lactate Dehydrogenase;Link;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Malignant Neoplasms;malignant oropharynx neoplasm;Measurable;Measurement;Measures;Mediating;Metabolic;metabolic imaging;Metabolic Pathway;metabolic phenotype;Metabolism;minimally invasive;Mission;Modeling;Molecular;mortality;Mutagens;NADH;NADP;Neoadjuvant Therapy;Neoplasm Circulating Cells;neoplastic cell;Nicotinamide adenine dinucleotide;Non-Invasive Detection;non-invasive imaging;Normal tissue morphology;novel;oxidation;Oxidation-Reduction;Patients;Pharmaceutical Preparations;phase 2 study;pre-clinical;Pre-Clinical Model;precision oncology;prospective;Pyruvate;real-time images;Recycling;Regimen;relative effectiveness;Research;Resistance;response;Solid Neoplasm;Spectrum Analysis;success;Systemic Therapy;Testing;Therapeutic;Time;Toxic effect;transcriptomics;Treatment Failure;treatment optimization;treatment response;tumor;Tumor Biology;Tumor Burden;tumor growth;Tumor Markers;tumor metabolism;United States National Institutes of Health;Work;Xenograft procedure

PROJECT_TITLE: Quantification of cisplatin sensitivity and resistance using metabolic imaging and circulating tumor cell (CTC) biomarkers


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

PHR: Plasticity underlies learning, and can partially mitigate the impact of neurodegenerative conditions.  Studying changes of neural interactions in the healthy brain at the cellular-level in vivo is necessary to  understand how they become altered in disease (e.g., Stroke, Alzheimer's disease). Specifically, this  project will lead to theory-grounded experimental studies of reorganization of cortical networks in an animal  model of stroke, paving a path for therapeutic targeted enhancements of plasticity counteracting impacts of  stroke.

PI_NAMEs: ALJADEFF, JOHNATAN  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Alzheimer's Disease;Animal Behavior;Animal Model;Animals;Area;Behavior;behavior change;Behavioral;Biological;Biological Models;Brain;Brain region;brain shape;Computer Models;Data;design;Disease;dynamic system;experience;experimental study;flexibility;Future;Goals;Image;in vivo;information processing;insight;Investigation;Knowledge;Laws;learned behavior;Learning;Link;Maps;mathematical model;Measures;Memory;Methods;Modeling;Motor Cortex;Nerve Degeneration;network models;neural;neural network;Neuronal Plasticity;Neurons;Neurophysiology - biologic function;Neurosciences;novel;Optics;optogenetics;Pattern;Process;Property;Resolution;Role;Route;spatiotemporal;Stroke;stroke model;Synaptic plasticity;Techniques;Testing;theories;therapeutic target;Time;Update;Work

PROJECT_TITLE: CRCNS: Emergence of coordinated multi-region brain activity supporting behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(50)R]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Prevention;Rare Diseases;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE Suicide is a major public health imperative in the US, and the rate of suicide is significantly higher among patients with head and neck cancer (HNC) compared with patients with cancer at other sites as well as the general US population. Screening for suicidal ideation and behavior is known to be an evidence-based suicide prevention strategy, and the Columbia Suicide Severity Rating Scale (C-SSRS) is considered the ideal suicide ideation screening tool. Our research will contribute to suicide prevention and mitigation by administering the C-SSRS in an HNC care setting, and evaluate the potential implementability of the tool in routine HNC care.

PI_NAMEs: OSAZUWA-PETERS, NOSAYABA  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Accident and Emergency department;Address;Adjustment Disorders;Adopted;Alcohols;Automobile Driving;cancer diagnosis;Cancer Etiology;Cancer Patient;Cancer Survivor;career;Caring;Cause of Death;Chronic Disease;chronic pain;Clinical;clinical practice;Consolidated Framework for Implementation Research;Data;Depression screen;design;Detection;Diagnosis;Distress;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation hybrid;Electronics;Evaluation;evidence base;Feedback;Feeling suicidal;follow-up;Future;Goals;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;Health;health care settings;high risk;ideation;implementation facilitators;implementation framework;implementation science;Individual;informant;insight;Intervention;Interview;Investigation;Knowledge;Link;Literature;Longitudinal Studies;Malignant Neoplasms;Measures;Mental Depression;Mentors;Methods;Modeling;Morbidity - disease rate;novel;Nurse Practitioners;Nurses;Oncologist;Oncology;Outcome;patient population;Patient Recruitments;Patient risk;patient screening;patient subsets;Patients;Persons;Population;Positioning Attribute;Prevalence;Prevention strategy;preventive intervention;Prospective cohort;Provider;psychiatric comorbidity;Psychiatric epidemiology;psychosocial;Public Health;public health relevance;Questionnaires;Reporting;Research;Research Design;Research Methodology;Research Personnel;Risk Management;routine care;routine screening;Sampling;screening;Screening procedure;Severities;Site;Spouses;Substance abuse problem;suicidal;suicidal behavior;suicidal morbidity;suicidal patient;suicidal risk;Suicide;Suicide attempt;suicide model;suicide mortality;Suicide prevention;suicide rate;Survivors;System;Testing;Thermometers;tool;Training;Triage;United States Food and Drug Administration;United States National Institutes of Health;University Hospitals;Work

PROJECT_TITLE: Suicide risk detection and mitigation in patients with head and neck cancer

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]