NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Contraception/Reproduction;Hypertension;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: CUPERTINO

ORG_NAME: PYRAMES, INC.

PHR: Project Narrative -- Non-invasive, continuous blood pressure monitoring for prenatal maternal health The goal of this proposal is development of a non-invasive device that is comfortable, low-cost and easy to use in order to monitor the blood pressure and changes in the pulse waveform shape of pregnant women. Close surveillance of women at risk of developing complications from hypertensive disorders of pregnancy potentially enables timely diagnosis and treatment before they develop significant maternal and neonatal morbidities related to hypertensive disorders of pregnancy, such as pre-eclampsia. This project is based on technology invented in Prof. Zhenan Bao’s lab at Stanford University and a fully-functional prototype device, and includes prospective data collection, usability and validation studies with women at different stages of pregnancy.

PI_NAMEs: QUAN, XINA  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Address;Affect;algorithm development;Algorithms;Ambulatory Blood Pressure Monitoring;Arterial Lines;artificial neural network;Biological Markers;Blood flow;Blood Pressure;Blood pressure determination;Blood Pressure Monitors;Breakthrough device;Calibration;Caring;Child;classification algorithm;Clinic Visits;Clinical;Clinical Research;Companions;Consent;Contralateral;cost;Data;Data Collection;data quality;Databases;design;Development;Device Designs;Devices;Diagnosis;Documentation;Engineering;Enrollment;Ensure;Evolution;Feedback;follow-up;Goals;Good Clinical Practice;Guidelines;health goals;Heart Rate;high risk;High Risk Woman;Home;Hospitalization;Hospitals;Hour;Hypertension;improved;improved outcome;Individual;Infant;Infant Mortality;Informed Consent;Institutional Review Boards;Intervention;Interview;invention;Late pregnancy;Licensing;Life Style Modification;light weight;Machine Learning;Maternal Health;maternal morbidity;Maternal Mortality;Measurement;Measures;Medical;Medical center;Modeling;Modification;Monitor;monitoring device;Mothers;neonatal morbidity;neural network;Neural Network Simulation;non-invasive monitor;Office Visits;older patient;Participant;Patient Compliance;Patients;personalized medicine;Pharmaceutical Preparations;Phase;phase 1 study;Physiologic pulse;Population Distributions;Positioning Attribute;Postpartum Women;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy hypertension;Pregnancy Outcome;Pregnant Women;Premature Birth;Premature Infant;prenatal;Prenatal care;preterm newborn;Production;prospective;Protocols documentation;prototype;Records;recruit;Risk;scale up;sensor;Shapes;Site;Special Population;Specific qualifier value;standard care;standard of care;Statistical Data Interpretation;success;Surveys;System;Techniques;Technology;Tennessee;Testing;Time;time use;tool;Training;Universities;usability;User Compliance;validation studies;wearable device;Woman

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (J2)]


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: NEW ORLEANS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Community violence is a major public health concern in the U.S. Information on the nutritional consequences of community violence is scarce. This proposal aims to examine the influence of community violence on food retail, food purchasing behavior, and dietary intake in low-income African American communities in Chicago, IL.

PI_NAMEs: SINGLETON, CHELSEA R (contact)

PROGRAM_OFFICER_NAME: PICHARDO, CATHERINE MELISSA

PROJECT_TERMS: Adult;Affect;African American;African American population;Anxiety;assault;Attention;Baltimore;Behavior;built environment;Businesses;Censuses;Characteristics;Chicago;Cities;Communities;Community Health;community violence;cost;Country;Data;Decision Making;density;Diet;Dietary intake;experience;Exposure to;Family;fast food;Food;food environment;Forcible intercourse;Future;Green space;Health;Health behavior;Health behavior and outcomes;Health Food;health inequalities;improved;Individual;interest;Interview;Investigation;Investments;Knowledge;Leisure Activities;Link;Literature;Low income;Measures;Mental Depression;Mental disorders;Murder;nutrition;Nutritional;Nutritional status;operation;Participant;Patient Self-Report;Perception;Physical activity;physical inactivity;Play;Policy Maker;Post-Traumatic Stress Disorders;Public Health;Race;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Restaurants;robbery;Role;Safety;Series;social health determinants;socioeconomics;Structure;Substance abuse problem;Supermarket;Surveys;Time;Travel;underserved community;Violence;violent crime;Walking

PROJECT_TITLE: Community Violence and its Impact on Food Retail, Food Purchasing Behavior, and Dietary Intake among Low-income African Americans


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Epigenetics is a discipline that will help us to understand how inherited gene activity, based on past environmental exposures, contributes to cancer. The purpose of this study is to identify and characterize epigenetic marks that contribute to the excess risk of monoclonal gammopathy of undetermined significance in African Americans, which is a precursor to multiple myeloma. The knowledge gained from this study may help us to understand the disparate trends of these plasma cell proliferative disorders by race as well as to predict, classify and intervene more effectively in high-risk populations.

PI_NAMEs: BROWN, ELIZABETH E (contact)

PROGRAM_OFFICER_NAME: CAGA-ANAN, EMILIE CHARLISSE F

PROJECT_TERMS: advanced analytics;Affect;African American;African American population;Age;American;Antibodies;Apoptosis;bead chip;Biological;Biological Markers;bisulfite sequencing;Bone Marrow;candidate identification;case control;Classification;Clinical;Clinical Data;clinically significant;Clonal Expansion;Complex;Cytogenetics;Data;Diagnostic;Discipline;Disease;Disparate;Disparity;DNA;DNA Sequence;Environmental Exposure;Environmental Risk Factor;Epidemiology;Epigenetic Process;epigenome;epigenomics;Etiology;European;Evaluation;Event;exome;Extramedullary;Family history of;functional genomics;Gene Expression;Genes;Genetic;genome wide association study;Geography;Germ Lines;Goals;Hematologic Neoplasms;Hematopoietic Neoplasms;Heritability;high risk;high risk population;improved;Incidence;Individual;Inherited;insight;International;Investigation;Knowledge;Leukocytes;Lymphoma;male;Malignant lymphoid neoplasm;Malignant Neoplasms;Maps;Messenger RNA;Methylation;methylome;Modeling;Modification;Monitor;Monoclonal gammopathy of uncertain significance;Multiple Myeloma;neoplastic cell;Obesity;Participant;peripheral blood;Plasma Cells;Play;Population;Positioning Attribute;posttranscriptional;Predisposition;Quantitative Trait Loci;Race;Resistance;Resources;Risk;Risk Factors;Role;Sampling;sex;Single Nucleotide Polymorphism;Site;Specificity;Technology;Testing;Time;transcriptome;transcriptome sequencing;trend;Validation;Variant

PROJECT_TITLE: Epigenetic contribution to the excess risk of MGUS in African Americans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative There is evidence to support positive multisensory exposures in the NICU (such as skin-to-skin, holding, and language exposure), but these interventions are not applied in a consistent manner, reducing their benefit to high-risk infants. The critical next step is to address knowledge gaps about the effects of daily, evidence- based, positive, and multisensory interventions provided to very preterm infants throughout the duration of NICU hospitalization, on brain development during an important period of time. This is important to public health as it impacts millions of infants and families worldwide, the NICU environment is a modifiable factor, and there is high demand for interventions that can change the experience of NICU hospitalization, improve early parent-child relationships, and optimize developmental outcomes.

PI_NAMEs: MATHUR, AMIT MOHAN;PINEDA, ROBERTA  (contact)

PROGRAM_OFFICER_NAME: SANTOS SCHMIDT, AUGUSTO FREDERICO

PROJECT_TERMS: 2 year old;Address;Admission activity;Age;Attention;Auditory;Behavioral;Biological Markers;Birth;Brain;Caring;Cerebrum;Complex;Cues;Development;Dose;early experience;Electroencephalography;Emotional;Enrollment;Environment;Environmental Exposure;evidence base;Evidence based intervention;experience;Exposure to;extreme prematurity;Family;Future;Goals;Health;high risk infant;Hospitalization;Hospitals;Hour;Human;improved;improved outcome;Infant;infant outcome;Intervention;intervention program;Knowledge;Language;language outcome;Life;Masks;Massage;Measures;Medical;Mental Health;Monitor;multisensory;Music;neonatal brain;Neonatal Intensive Care Units;neurodevelopment;Newborn Infant;Outcome;Pain;Parent-Child Relations;parenting intervention;Parents;Pathway interactions;Pattern;Personal Satisfaction;Predisposition;Pregnancy;premature;Premature Infant;primary outcome;procedural pain;Process;programs;Public Health;Publishing;Randomized;Reporting;Research;Risk;Sampling;Sensory;sensory mechanism;sensory stimulus;Sensory Thresholds;Skin;Skin Care;social;Specific qualifier value;standard of care;Standardization;Stimulus;Structure;Tactile;Testing;therapy design;Time;Toddler;tool;Touch sensation;treatment as usual;Veins;volunteer;Work

PROJECT_TITLE: Multisensory interventions to improve neurodevelopmental outcomes of preterm infants hospitalized in the neonatal intensive care unit


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Prevention;Screening and Brief Intervention for Substance Misuse;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE When men who have sex with men use alcohol excessively, they experience greater risk of HIV infection; they may also have reduced adherence to and less retention in pre-exposure prophylaxis (PrEP) programs. A brief alcohol intervention, provided over about six weeks, may substantially reduce alcohol use among men who have sex with men. This trial will be conducted in Vietnam to assess the impact of the brief alcohol intervention on retention in a PrEP program and adherence to PrEP.

PI_NAMEs: GO, VIVIAN F. (contact);LE, GIANG M;MILLER, WILLIAM C

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;AIDS prevention;alcohol abstinence;Alcohol consumption;alcohol misuse;alcohol use disorder;alcohol use initiation;Alcohols;antiretroviral therapy;arm;Asia;Back;Behavioral;binge drinking;Biological Assay;Biological Markers;brief alcohol intervention;Caring;Chlamydia Infections;Clinic;Clinical;Cognitive Therapy;Consolidated Framework for Implementation Research;Consumption;cost effective;cost effectiveness;cost estimate;cost per quality-adjusted life year;cost-effectiveness ratio;design;drinking;effectiveness evaluation;effectiveness outcome;Elements;eligible participant;Ensure;Epidemic;Evaluation;Event;experience;Gonorrhea;hazardous drinking;Health;Heavy Drinking;HIV;HIV Infections;Human immunodeficiency virus test;hybrid type 1 design;Hybrids;implementation outcomes;implementation process;implementation/effectiveness;improved;Incidence;incremental cost;incremental cost-effectiveness;Individual;Injectable;Injecting drug user;Intervention;intervention cost;Interview;Measures;Mediating;Medical;medication compliance;men;men who have sex with men;Methods;microcosting;Monitor;motivational enhancement therapy;Oral;Outcome;Participant;Patient Self-Report;Persons;Pharmacy facility;phosphatidylethanol;Policy Maker;pre-exposure prophylaxis;pressure;prevent;Prevention;primary outcome;programs;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;Records;reduced alcohol use;Regimen;Reporting;Risk;Risk Behaviors;scale up;secondary outcome;Self Assessment;Sex Behavior;Sexual Health;sexual risk reduction;Sexually Transmitted Diseases;social stigma;standard of care;Syphilis;Telephone;telephone session;Testing;therapy adherence;Time;timeline;tool;treatment arm;Universities;uptake;Vietnam;Vietnamese;Viral;Visit

PROJECT_TITLE: A brief alcohol intervention to reduce alcohol use and improve PrEP ouctomes among men who have sex with men: A randomized controlled trial in Vietnam


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases

ORG_CITY: LITTLE ROCK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: NARRATIVE The studies proposed in this application will investigate the role of Notch3 in integrating signals from the tumor microenvironment that promote tumor growth, bone destruction, and drug resistance in multiple myeloma. Successful completion of these studies will provide the rationale to target Notch3 in the clinic to improve MM patient outcomes, including those with refractory disease.

PI_NAMEs: SABOL, HAYLEY  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Antibodies;Apoptosis;Binding;Bioinformatics;Biology;bone;Bone Diseases;Bone Marrow;Bortezomib;career;Cell Communication;Cell Proliferation;Cell Survival;Cells;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Communication;design;Dexamethasone;Disease;Disease Resistance;Dose Limiting;Drug resistance;drug resistance development;effective therapy;efficacy evaluation;Exhibits;Fellowship;Foundations;fracture risk;Gene Expression;Gene Expression Regulation;genetic signature;Goals;Growth;Hematologic Neoplasms;Human;Image;Immunocompetent;improved;in vivo;inhibitor therapy;knock-down;Laboratories;lenalidomide;Lytic Metastatic Lesion;Malignant - descriptor;Malignant Neoplasms;Marrow;Mediating;Membrane;Mentors;migration;Molecular;mouse model;multidisciplinary;Multiple Myeloma;Mus;neoplastic cell;Newly Diagnosed;notch protein;NOTCH3 gene;novel;Osteoclasts;Osteocytes;Osteolytic;Outcome;overexpression;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Plasma Cells;Play;Pre-Clinical Model;pre-doctoral;Proliferating;Proteasome Inhibitor;Publishing;Quality of life;Refractory;Refractory Disease;Regimen;Regulation;Relapse;relapse patients;Reporting;Resistance;response;Role;Scientist;side effect;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stromal Cells;targeted treatment;Testing;therapy resistant;Training;transcriptome;treatment response;tumor;Tumor Burden;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Up-Regulation;Work;Xenograft procedure

PROJECT_TITLE: Targeting Notch3 for the treatment of multiple myeloma


ADMINISTERING_IC: HL

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Infectious Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Cardiovascular disease remains the leading cause of death in the United States, with myocarditis contributing to 42% of all sudden deaths in young adults annually, yet the relationship between viral infection and fatal arrhythmias is unknown. Our research reveals that cardiac cellular junctional structures, essential for normal electrical activity in the heart, are targeted during infection to facilitate viral replication and spread. This research will identify mechanisms underlying viral sudden cardiac death and mechanisms of arrhythmogenic ion channel remodeling, and will reveal therapeutic targets applicable not just to myocarditis, but also to the broad array of heart diseases involving deadly disruption of cardiac intercellular communication.

PI_NAMEs: SMYTH, JAMES WILLIAM (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Action Potentials;Acute;Adenovirus Infections;Adenoviruses;Adhesions;Affect;Anti-viral Agents;Arrhythmia;beta catenin;Biochemical;Biological Models;Biology;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cause of Death;Cell Line;clinical efficacy;Clinical Research;Confocal Microscopy;Connexin 43;Connexins;Coupling;Dangerousness;Data;Electrons;Electrophysiology (science);Etiology;Gap Junctions;Gene Expression;Generations;Genetic Transcription;Goals;Heart;Heart Diseases;Heart failure;Human;human induced pluripotent stem cells;Immune response;in vivo Model;induced pluripotent stem cell derived cardiomyocytes;Infection;Inflammation;Inflammatory;innovation;insight;Intercalated disc;intercellular communication;Intercellular Junctions;Ion Channel;Knowledge;Mechanics;model development;Modeling;Molecular;Molecular Probes;Mus;Mutation;Myocarditis;Myocardium;novel;Pathogenesis;Pathologic;Phosphoric Monoester Hydrolases;Phosphotransferases;PIK3CG gene;Potassium;protein expression;protein function;Proteins;Proteomics;Regulation;Research;research study;Role;Serotyping;Signal Transduction;Species Specificity;Structure;sudden cardiac death;Sudden Death;System;Testing;Therapeutic Intervention;therapeutic target;Time;transcription factor;Transgenic Animals;ultra high resolution;United States;Ventricular;Viral;viral myocarditis;Viral Proteins;Virus Diseases;Virus Replication;voltage;Work;young adult

PROJECT_TITLE: Viral subversion of intercellular coupling during myocarditis

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative  Dysregulation of molecular machinery and molecular pathways that establish precise circuit connections and specific subtype identity of cerebral cortex projection neurons disrupts sensation, skilled movement, social behaviors, and high-level cognition, and plays central roles in neurodevelopmental and neurodegenerative diseases. Axonal growth cones are semi-autonomous, subcellular compartments at tips of extending axons that rapidly integrate extracellular signals to control axon growth, developmental guidance to targets, maturation into correct functional synapses, and maintenance of appropriate and healthy neural circuits. Vast distances (103- 105 cell body diameters) separate growth cones from their nucleus-containing somata, strongly suggesting that local, subtype-specific growth cone proteins underlie proper growth cone function, and motivating this project’s integration of novel subcellular isolation approaches with ultra-low-input proteomics via state-of-the-art mass spectrometry to identify key proteins regulating axonal navigation of subtype-specific projection neurons in mouse cerebral cortex during development, and in disease.

PI_NAMEs: TILLMAN, DUSTIN ELIOT (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Adult;autism spectrum disorder;Axon;axon growth;axon guidance;axonal pathfinding;Behavior;Behavioral;candidate selection;causal variant;Cell Nucleus;Cells;Cerebral cortex;Chemicals;Cognition;Cognitive;combinatorial;Complex;Contralateral;Cues;Degradation Pathway;Development;Diameter;Disease;Environment;Esthesia;extracellular;Future;Genes;genetic approach;genetic manipulation;Genetic Transcription;Growth Cones;Hour;In Vitro;in vivo;Intellectual functioning disability;Investigation;Link;Maintenance;Maps;Mass Spectrum Analysis;Molecular;Motor;Movement;Mus;Nature;Nervous System Disorder;neural circuit;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;neuron development;neuronal circuitry;neuronal growth;Neurons;novel;Nuclear;Parents;Pathway interactions;Play;Process;Protein Biosynthesis;protein degradation;protein function;Proteins;Proteome;Proteomics;proteostasis;Regulation;Research;response;RNA;RNA Splicing;Role;Sensory;Signal Transduction;skills;Social Behavior;subcellular targeting;Synapses;synaptogenesis;therapeutic target;transcription factor;transcriptome;Translational Regulation;Variant;Work;Zinc Fingers

PROJECT_TITLE: Subcellular Proteomic Investigation of Projection Neuron Growth Cones in Developing Mouse Cortex


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE: Glioblastoma multiforme (GBM) is the most common brain malignancy in adults and is universally lethal, demonstrating a desperate need for more efficacious therapies. Poor survival outcomes are attributed to tumor recurrence, which is believed to arise from a chemo- and radioresistant, highly plastic population of glioblastoma stem cells. In this proposal we explore a completely novel function for EYA2 in centrosome biology and the molecular mechanism by which it regulates proliferation and mitotic spindle formation in GBM, presenting a novel potential therapeutic target for the disease.

PI_NAMEs: WOLIN, ARTHUR R (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: 2-tyrosine;3' Untranslated Regions;Adult;AKAP9 gene;Antibodies;Apoptosis;Binding;Biological Assay;Biology;Brain;Cell Cycle Arrest;Cell Cycle Progression;Cells;Centrosome;Characteristics;Chromosome Segregation;Co-Immunoprecipitations;Collaborations;Cytoplasm;Data;Defect;Development;Disease;efficacious treatment;Exhibits;experimental study;Eye;Foundations;G2/M Arrest;Genetic Variation;Glioblastoma;immunocytochemistry;In Vitro;inhibitor;knock-down;Link;Malignant Neoplasms;Mass Spectrum Analysis;mimetics;Mitosis;Mitotic;Mitotic spindle;Molecular;mutant;nerve stem cell;novel;Nuclear;overexpression;Peptides;pharmacologic;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotyrosine;PLK1 gene;Population;Proliferating;Protein Tyrosine Phosphatase;Proteins;radioresistant;Recurrent tumor;Role;small hairpin RNA;stem;stem cell population;stem cell proliferation;stem cells;survival outcome;Testing;therapeutic target;Time;Transcription Coactivator;Trimethoprim-Sulfamethoxazole;tumorigenic;Western Blotting;Work

PROJECT_TITLE: Elucidating the role of EYA2 at centrosomes in glioblastoma stem cells


NIH_SPENDING_CATS: Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative  Traumatic spinal cord injury is a devastating acquired disorder leading to permanent functional deficits, including loss of voluntary movement control due to damage and lack of repair of corticospinal neurons, the subtype of cortical projection neurons that normally connect the cerebral cortex to the spinal cord via segmentally-specific, exceptionally long circuitry that can extend up to a meter in humans– up to 100,000 times as long as the “cell body” size. The inability of corticospinal neurons to re-generate is in stark contrast with their ability to generate precise circuitry during development, during which axonal growth cones, subcompartments at the ends of these exceptionally long growing axons, respond to their environment relatively independently and are thus responsible for axonal guidance, and establishment and maintenance of functional synapses and functional circuitry. Using novel approaches to study cellular subcompartments of these vastly “polarized” neurons, I will investigate cell body- and growth cone-localized RNA and protein molecular machinery and thus local mechanisms responsible for executing developmental and treatment-enabled regenerative growth of corticospinal neurons, toward future development of targeted therapies for people with disability from spinal cord injury.

PI_NAMEs: VICENT ALLENDE, MARIA ALEJANDRA (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Adult;Animal Model;Axon;axon growth;axon guidance;Body Size;candidate identification;candidate selection;Cell Physiology;Cells;Central Nervous System;Cerebral cortex;Clinical;combinatorial;comparative;Cytoskeleton;Data;Development;disability;Disabled Persons;Disease;Elements;Environment;Exhibits;Future;gain of function;Genetic;genetic manipulation;Goals;gray matter;Growth;Growth Cones;Human;In Vitro;in vivo;injured;Injury;insight;Investigation;Label;Maintenance;Mediating;meter;Methodology;Modeling;Molecular;Motor output;Movement;Mus;Natural regeneration;Nerve Regeneration;nerve supply;neuron development;neuron regeneration;neuronal cell body;neuronal circuitry;neuronal growth;Neurons;novel strategies;Output;Parents;Persons;postnatal;postsynaptic;Process;programs;Proteins;Proteome;Proteomics;receptor;Recovery of Function;recruit;regenerative;Regenerative capacity;regenerative growth;Regulation;repaired;Research;RNA;Signal Transduction;Spinal Cord;Spinal cord injury;subcellular targeting;Synapses;synaptogenesis;System;targeted treatment;Therapeutic;Thoracic spinal cord structure;trafficking;Training;Transcript;transcriptome;transcriptome sequencing;translational progress;Translations;Validation;Work

PROJECT_TITLE: Subcellular investigation of molecular programs responsible for corticospinal neuron development and treatment-enhanced regeneration


NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD)

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This project will advance our knowledge of how mutations in the DEAD-box protein DDX3X dysregulate normal cellular metabolism and cause neurodevelopmental disease. We will gain much needed insight into how genetic defects in RNA metabolism lead to neurodevelopmental disorders such as autism spectrum disorder, epilepsy, and intellectual disability. Our proposed studies will guide a framework for understanding and develop treatments for patients with DDX3X syndrome.

PI_NAMEs: XU, ALBERT Y (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: 5' Untranslated Regions;Address;Affect;autism spectrum disorder;Binding;Biology;brain malformation;Cell Line;Cell Nucleus;Cell Physiology;Chemicals;Complex;CRISPR interference;Cytoplasm;Data;Developmental Disabilities;Disease;Epilepsy;Eukaryotic Initiation Factors;experimental study;Female;Genes;Genetic;genome-wide;Germ-Line Mutation;High-Throughput Nucleotide Sequencing;HIV-1;Immunofluorescence Microscopy;in vivo;insight;Intellectual functioning disability;Knowledge;Lead;Link;Measures;Messenger RNA;Metabolism;Modification;Molecular;Molecular Chaperones;mRNA Export;mRNA Translation;Mutagenesis;Mutation;Neurodevelopmental Disorder;Nuclear;Nuclear Export;Nuclear Localization Signal;Pathogenicity;Pathway interactions;patient - derived stem cells;Patients;Peptide Initiation Factors;Play;Process;Protein Family;Proteins;Regulation;Ribosomes;RNA;RNA Helicase;RNA metabolism;Role;Stains;Structure;Syndrome;Testing;therapy development;Transcript;Transformed Cell Line;Translating;Translation Initiation;Translations

PROJECT_TITLE: Investigating the role of DDX3 in regulating RNA structure and mRNA export

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Rare Diseases

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Kaposi’s sarcoma (KS) is one of the most common AIDS-associated malignancies. This cancer is known to be caused by Kaposi’s sarcoma herpes virus (KSHV). Despite years of the progress on our knowledge of how the virus causes this cancer, an outstanding paradox still remains unresolved. The viral gene, vGPCR, has been known to be necessary and sufficient for KS tumor development. However, vGPCR is produced in the lytic stage cells that destined to die to produce more virus particles. In this study, we aim to tackle the provocative question, how can vGPCR, a lytic viral gene expressed in cells destined to die, can cause cancer? To address this decades-long conundrum, we have development novel animal models and an engineered artificial skin platform. Our study will identify a totally new way of cancer initiation, advance our understanding of KS tumor development, and help to design novel anti-KS therapeutics.

PI_NAMEs: HONG, YOUNG-KWON  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Address;Affect;AIDS related cancer;Animal Model;Animals;Artificial skin;Automobile Driving;Biogenesis;cadherin 5;Cancer Etiology;cancer initiation;CD19 gene;Cell fusion;Cell Reprogramming;cell type;Cells;Coculture Techniques;cofactor;Colon Carcinoma;Data;design;Development;Endothelial Cells;Endothelium;Engineering;Event;Exclusion;exosome;Experimental Animal Model;extracellular vesicles;Extravasation;Foundations;G-Protein-Coupled Receptors;gain of function;Gene Expression;Goals;HIV;HIV Seropositivity;Human;Human Herpesvirus 8;humoral immunity deficiency;Immune;Immunity;implantation;In Vitro;in vitro Model;Individual;Inflammation;Injections;innovation;insight;Kaposi Sarcoma;Keratin;keratinocyte;Knockout Mice;Knowledge;Lymphocyte;Lytic;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;metaplastic cell transformation;microphysiology system;Modeling;Molecular;Mus;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;novel;Oncogenic;Organ;Parabiosis;paracrine;Pathogenesis;Pathogenicity;Phenotype;Process;promoter;Proteins;Reporter;Role;Series;Serum;Skin;Solid;System;Therapeutic;transdifferentiation;tumor;tumorigenesis;uptake;Vascularization;Viral;Viral Genes;Viral Oncogene;Viral Proteins;Virion;Virus;Work

PROJECT_TITLE: (PQ6) vGPCR-Mediated Paracrine Transformation for Kaposi Sarcoma


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The Cancer Biology Training Grant provides trainees with the fundamental skills necessary for outstanding careers in biomedical cancer research together with an appreciation of the challenges and complexity of cancer in the clinical setting. The training program emphasizes rigorous training in basic cancer-related laboratory research enriched by career enhancement activities and educational forums that address important topics in clinical and translational cancer research.

PI_NAMEs: JACKSON, MARK W. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Cancer Biology;Grant;Training

PROJECT_TITLE: Cancer Biology Training Grant


NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Congenital Structural Anomalies;Dietary Supplements;Genetics;Human Genome;Neurosciences;Nutrition;Pediatric;Prevention;Rare Diseases;Spina Bifida

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Folic acid (FA) supplementation is an effective modifier of neural tube defect (NTDs) prevalence, although a significant proportion of NTD cases are FA resistant. We hypothesize that some FA-resistant NTDs may be prevented by intervention with glycine. Discerning the mechanisms underlying the beneficial effects and relating them to known human NTD gene variants may enable us to expand effective intervention strategies to prevent previously unpreventable NTDs.

PI_NAMEs: FINNELL, RICHARD H. (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Alternative Therapies;Alzheimer's Disease;Automobile Driving;Biological Assay;Biological Markers;Birth;bisulfite;Carbon;Categories;Cells;Cessation of life;Child;Chromatin;cohort;Complex;Conceptions;Congenital Abnormality;cost estimate;Defect;Diabetes Mellitus;effective intervention;efficacy testing;Embryo;Epigenetic Process;epigenomics;Etiology;Family;Folic Acid;Folic acid fortification;folic acid supplementation;Food Supply;Formates;functional genomics;Funding;Gene Expression;Genes;Genetic;genetic variant;genome sequencing;Glycine;Health;Health Policy;Homeostasis;Human;human model;humanized mouse;Impairment;In Vitro;in vitro Model;in vivo;Infant Mortality;Influenza;Intervention;Investigation;Knock-out;Knockout Mice;Live Birth;malformation;Medical Care Costs;Meningomyelocele;Metabolic;Metabolism;metabolome;Methylation;Mitochondria;Modeling;Molecular;Monitor;Mouse Strains;multiple omics;Mus;Neonatal Mortality;Neural tube;Neural Tube Defects;Neuroepithelial;novel;Nutritional;Organoids;Outcome;oxidation;Oxidation-Reduction;Pathway interactions;Population;Positioning Attribute;precision medicine;Pregnancy;Prevalence;prevent;Prevention;Process;programs;Proteomics;Public Health;Research;Resistance;Resolution;Risk;Risk Factors;stable isotope;Stroke;success;Supplementation;Target Populations;Technology;Testing;trafficking;transcriptomics;United States;uptake;Variant;weapons;whole genome;WNT Signaling Pathway;Work

PROJECT_TITLE: Intervention Strategies for Non-Folate Responsive Neural Tube Defects

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative A steady stream of new researchers is necessary to continue the fight against cancer, the primary cause of death in the U.S. The training of a diverse workforce is a key component to the next generation of scientists. The goal of this Cancer Biology Training Program is to continue to give trainees a broad exposure to the many areas of cancer research, so that they can learn multidisciplinary and cutting-edge approaches to better understand and treat cancer, thereby reducing its overall burden nationwide.

PI_NAMEs: WANG, PEI ;YANG, FENG-CHUN  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Cancer Biology;Training Programs

PROJECT_TITLE: Cancer Biology Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Hospitalized children who develop a venous thromboembolism (VTE), a blood clot in the deep veins or pulmonary vasculature, have an increased risk of morbidity from long term pain and venous insufficiency, as well as increased mortality. The current lack of established methods for assessing VTE risk or applying safe and effective VTE prevention strategies as a standard component of hospital admission for children has led to the continuously increasing incidence of hospital-acquired VTE. Completing the aims of this study will contribute to the NIH mission to apply scientific knowledge to enhance health, lengthen life and reduce illness and disability in children through establishing a validated pediatric VTE risk assessment model, identifying barriers to hospital staff implementing risk models and determining the incidence and characterization of bleeding in hospitalized children to create safe thromboprophylaxis methods.

PI_NAMEs: JAFFRAY, JULIE ANN (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Address;Adult;aged;Anticoagulants;Anticoagulation;Area;Award;Biological Assay;Blood coagulation;blood product;Calibration;California;career;career development;Case/Control Studies;Characteristics;Child;Child Care;Childhood;Clinical;Clinical Research;Clinical Trials;cohort;Computerized Medical Record;Data;deep vein;demographics;density;design;Development;Diagnosis;disability;Discrimination;Disease;Dose;Drug Monitoring;effective intervention;efficacy evaluation;Enrollment;Environment;Event;experience;Faculty;Focus Groups;Funding;Future;Goals;Health;Health Care Costs;Hemoglobin;Hemorrhage;high risk;Hospitalization;Hospitalized Child;Hospitals;implementation science;improved;Incidence;indexing;Information Technology;inpatient service;Inpatients;Institution;Intervention Trial;Interview;Knowledge;Knowledge acquisition;Laboratories;large datasets;Life;Location;Logistic Regressions;Los Angeles;Lung;Measures;Medical;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;Multicenter Studies;Multivariate Analysis;Names;Newly Diagnosed;Nurses;Outcome;Pain;Patients;Pediatric Hospitals;pediatric patients;Pediatrics;Pharmaceutical Preparations;Phase;Physicians;Populations at Risk;prevent;Prevention;Prevention strategy;prophylactic;prospective;Provider;Publishing;Qualitative Research;Random Allocation;Randomized, Controlled Trials;Registries;Research;Research Design;Research Personnel;Risk;Risk Assessment;Risk Factors;ROC Curve;Safety;Sampling;Severities;Signs and Symptoms;skill acquisition;skills;Specialist;standard of care;Standardization;Structure;success;Target Populations;Thrombosis;Time;Training;training opportunity;Transcript;United States National Institutes of Health;Universities;uptake;Validation;Venous Insufficiency;venous thromboembolism

PROJECT_TITLE: Validation of a pediatric thrombosis risk assessment model and characterization of bleeding in hospitalized children through the Children's Hospital Acquired Thrombosis (CHAT) Consortium

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Dietary Supplements;Natural Products;Nutrition;Regenerative Medicine;Transplantation

ORG_CITY: PULLMAN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Narrative Natural medicinal compounds (NMC) such as curcumin from turmeric, acemannan from aloe vera and essential nutrients such as Vitamin D3 can improve healing of bone disorders. The objective of this research is to test our central hypothesis, which is, NMC loaded doped CaP-based porous 3D printed scaffolds can significantly enhance osteogenic and angiogenic properties in vivo. Our long-range goal is to demonstrate clinically relevant patient matched, doped CaP or CaP– polymer scaffolds with NMCs that will substitute autologous bone. NMCs can also replace GFs and proteins for faster healing, and work on other materials such as titanium for applications in load-bearing or non load-bearing implants.

PI_NAMEs: BOSE, SUSMITA  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3D Print;absorption;Aloe vera plant;Alveolar Ridge Augmentation;angiogenesis;anti-cancer;Anti-Inflammatory Agents;antimicrobial;Arthritis;Autologous;Autologous Transplantation;Beds;Biocompatible Materials;Biological;Biological Availability;Biomimetics;bone;bone cell;Bone Diseases;bone healing;bone health;bone repair;Bone Tissue;Bone Transplantation;calcium phosphate;Cells;Ceramics;chelation;Chemistry;Chemopreventive Agent;Cholecalciferol;Clinical;clinical application;Clinical Research;clinically relevant;Curcumin;Data;Defect;Dental;Dental Materials;Dentistry;design;Distal;Dose;Exhibits;FASTK Gene;Femur;Filler;Goals;Growth;Growth Factor;Harvest;healing;Hydrophobicity;Immune response;Implant;improved;In Vitro;in vivo;Inflammation;innovation;Kinetics;Knowledge;Liposomes;maxillofacial;Measures;mechanical properties;Mechanics;Medicine;metabolic rate;Metals;Methods;Micelles;Modeling;next generation;Nutrient;Operative Surgical Procedures;Orthopedics;Oryctolagus cuniculus;Osseointegration;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;osteogenic;Patients;Performance;polycaprolactone;Polyethylene Glycols;Polymers;Porosity;Powder dose form;practical application;preclinical study;Property;Proteins;Rattus;reconstruction;repaired;Research;response;Role;scaffold;Serum;Site;Spinal Fusion;Testing;Tissues;Titanium;Trace Elements;Tumeric;Viscosity;Weight-Bearing state;Work

PROJECT_TITLE: 3D Printed Calcium Phosphate Scaffolds with Natural Medicinal Compounds for Dental Applications

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: The proposed research is relevant to public health because improved methodologies for modeling viral rebound trajectories will be useful in the discovery of predictors of viremia control and the assessment of effects of novel therapeutic interventions on time to viral load rebound or altered viral set point following the discontinuation of the antiretroviral treatment, benefit both ongoing and future clinical studies in HIV cure research, and ultimately improve our capacity to find a cure for HIV. Thus, the proposed research is relevant to the part of NIAID’s mission that pertains to conducting and supporting research to understand and treat infectious diseases.

PI_NAMEs: WANG, RUI  (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: Accounting;Address;Affect;AIDS clinical trial group;Algorithms;antiretroviral therapy;Binding;Biological Assay;biomarker selection;Clinical Research;cohort;Collaborations;Communicable Diseases;Data;data integration;design;Development;Disease remission;Drug Costs;Drug Interactions;Drug resistance;Evaluation;expectation;feature selection;flexibility;Future;Gifts;Heterogeneity;high dimensionality;HIV;HIV Infections;Immunologic Factors;improved;Individual;innovation;insight;Interruption;Intervention;Mediation;Methodology;Methods;Mission;Modeling;mortality;National Institute of Allergy and Infectious Disease;Non-linear Models;novel therapeutic intervention;novel therapeutics;Outcome;Parameter Estimation;Patients;Pharmaceutical Preparations;Phase;Predictive Factor;Prevalence;primary endpoint;Process;Public Health;Randomized;Reaction Time;Recording of previous events;Research;Research Personnel;Research Support;Resources;response;RNA;Role;Sample Size;side effect;Source;Subgroup;success;Techniques;Testing;Therapeutic Agents;Time;tool;Viral;Viral load measurement;Viral Load result;viral rebound;Viremia;Virus Replication;Withdrawal;Work

PROJECT_TITLE: Modeling of Viral Load Trajectories for HIV Cure Research

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: ATHENS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Mutations that accumulate throughout the life cycle can result in cancer, infertility, and aging. This proposal will characterize how multicellular organisms control genome structure and development in order to reduce the impact of new mutations, focusing on plant transposons because it is possible to follow the spread of transposon-mediated mutations soon after they arise. The goal is to establish general principles that limit the persistence of mutations in diverse species, including humans.

PI_NAMEs: NELMS, BRADLEE  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Aging;Arabidopsis;Biological Assay;Buffers;Cell division;Cells;cellular development;Chromatin;Chromosome Structures;coping;deep sequencing;Defect;Development;DNA Damage;Epigenetic Process;Face;Genes;Genetic Screening;Genome;Germ Cells;Germ Lines;Goals;Grain;Growth;Haploidy;Human;Individual;Infertility;insight;Life Cycle Stages;Maize;Malignant Neoplasms;Mediating;Meristem;Microscopy;Mutation;Mutation Detection;neuronal cell body;novel strategies;Organism;Pattern;Plants;Pollen;Population;pressure;prevent;Process;Regulation;sample fixation;single-cell RNA sequencing;Somatic Cell;Somatic Mutation;stem cell niche;stem cells;Structure;Testing;Tissues;Work

PROJECT_TITLE: Developmental mechanisms that buffer mutational load in plants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(55)R]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Microbiome

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE While it is clear that microbial diversity is important to human health, the mechanisms that underpin why remain elusive. This proposal seeks to shed light on how complex microbial communities assemble and function to affect host health through examining diversity at the strain level using naturally occurring genetic variation as tool for discovery.

PI_NAMEs: BISANZ, JORDAN ADAM (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Address;Affect;Animal Model;Anti-Bacterial Agents;Anti-malarials;Autoimmune Diseases;Big Data;bile acid metabolism;Bile Acids;Biological;Communicable Diseases;Communities;comparative genomics;Complex;Computational Biology;Coupled;Data;Equilibrium;Family;fecal transplantation;Gastrointestinal tract structure;gene discovery;Genetic Variation;Genome;Genotype;Gnotobiotic;Goals;gut microbiome;Health;High-Throughput Nucleotide Sequencing;host microbiome;host-microbe interactions;Human;Human Microbiome;laboratory experiment;Libraries;Malignant Neoplasms;Medicine;Metabolic;Metabolic Pathway;Microbe;microbial;microbial community;microbiome research;Mission;model organism;Oral Administration;Organism;Output;Pathway interactions;Pharmaceutical Preparations;Phenotype;Phylogenetic Analysis;Physiology;programs;rational design;Research;Resources;response;Shapes;Sum;Therapeutic;tool;translational applications;transplantation therapy;Variant

PROJECT_TITLE: Decoding Microbial Diversity in the Human Gut Microbiome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Genetics;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: The formation of the distal air sacs (alveolarization) requires the development of blood vessels by the process of angiogenesis. Disruption of angiogenesis and alveolarization in infants causes bronchopulmonary dysplasia, the most common complication of premature birth. Our studies will identify new pathways that direct angiogenesis in the developing lung, and explore new therapeutic strategies to promote lung growth by enhancing angiogenesis, an approach that may be applicable to diseases affecting both infants and adults.

PI_NAMEs: ALVIRA, CRISTINA MARIA (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Adult;Affect;Air;Air Sacs;Alveolar;Alveolar Cell Type I;angiogenesis;Angiogenesis Inhibition;Appearance;Area;ATAC-seq;Automobile Driving;Birth;blood vessel development;Blood Vessels;Bronchopulmonary Dysplasia;Cell Proliferation;Cell Separation;Cells;Chronic;Complication;Cues;Data;Data Set;Development;Disease;Distal;Endothelial Cells;endothelial stem cell;Endothelium;Experimental Models;Gases;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Growth;Heterogeneity;Hyperoxia;Image;Impairment;In Vitro;in vivo;Infant;KITLG gene;Knockout Mice;Knowledge;Life;Ligands;loss of function;Lung;lung development;lung injury;Mediating;Microcirculation;migration;Molecular;mouse model;Mus;Natural regeneration;Neonatal Hyperoxic Injury;NF-kappa B;novel;novel strategies;novel therapeutic intervention;Organ;paternal imprint;Pathway interactions;Perinatal;Phase;Phenotype;Population;postnatal;postnatal development;premature;Premature Birth;Process;Proliferating;rapid growth;receptor;receptor expression;Resolution;response;Role;self-renewal;Signal Transduction;single-cell RNA sequencing;Sorting;stem;stem cell population;stem cells;Stimulus;Surface;targeted treatment;Testing;Time;transcription factor;transcriptomics;Transgenic Organisms;Translating;Vascular Endothelial Cell;Vascular regeneration;virtual;Work

PROJECT_TITLE: Developmental Heterogeneity of Pulmonary Endothelial Phenotype at Single Cell Resolution

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Lung;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and current therapy only treats symptoms but cannot stop progression of this debilitating disease. We have found evidence that vascular dysfunction leads the development of the type of lung destruction that is found in COPD. In this proposal, we aim to uncover new therapies targeting the vascular impairments causing the disease state of COPD in the hopes of improving the lives of millions of patients.

PI_NAMEs: RACANELLI, ALEXANDRA CHRISTIN (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Acute;Address;Adult;Airway Disease;airway obstruction;Alveolar;Binding;Biological Models;Blood capillaries;Blood Vessels;Capillary Endothelial Cell;career development;Cause of Death;Cell Compartmentation;Cell Separation;Cell Therapy;Chronic;Chronic Obstructive Pulmonary Disease;cigarette smoke;Cigarette smoke-induced emphysema;Clinical;Data;density;Development;Development Plans;Disease;Elastases;Endothelial Cells;Endothelium;Environment;experimental study;exposure to cigarette smoke;Extracellular Matrix;Gene Modified;Genes;Glycoproteins;Goals;Growth Factor;Homeostasis;Human;human model;Impairment;improved;Inflammation;Injury;Leucine;Link;Lung;Lung Diseases;lung injury;Malignant Neoplasms;Medicine;Meditation;Mentorship;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Natural regeneration;neutralizing antibody;new therapeutic target;novel;novel strategies;Organ;Organoids;Pathogenesis;Pathologic;Patients;Permeability;Phenotype;Play;Pulmonary Emphysema;pulmonary function;Pulmonary Inflammation;receptor;repaired;Research Personnel;Resources;Respiratory Signs and Symptoms;response;response to injury;Role;Severities;Severity of illness;Signal Transduction;Structure;Structure of parenchyma of lung;symptom treatment;Syndrome;Testing;Therapeutic;Tissues;Training;Transforming Growth Factor beta;vascular abnormality;Vascular Diseases;Vascularization

PROJECT_TITLE: The role of endothelial derived Leucine-Rich Alpha-2-Glycoprotein 1 (LRG1) in the pathogenesis of COPD

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Clinical Research;Data Science;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE: This application proposes a Kidney Precision Medicine Project Tissue Interrogation Site (TIS) for the mapping of a diverse set of acute kidney injury (AKI) and chronic kidney disease (CKD) biopsies and subsequent construction of detailed multiomic molecular atlases. Atlases will be generated using an innovative and state-of-the-art multimodal imaging pipeline consisting of matrix-assisted laser desorption/ionization imaging mass spectrometry, autofluorescence, and stained microscopy. Spatial transcriptomics and proteomics will be used for cross-modal biological validation of the imaging data, and advanced data analysis strategies will reveal disease state/transition/class-specific biomarkers, provide insight into key molecular pathways that characterize heterogenous tissue regions, and explore potential disease subgroups; all across a diverse patient cohort with the objective of identifying specific biomarkers of disease.

PI_NAMEs: SPRAGGINS, JEFFREY M (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Academic Medical Centers;Acute Renal Failure with Renal Papillary Necrosis;Affect;Age;analysis pipeline;Analytical Chemistry;Anatomy;Atlases;Automobile Driving;biocomputing;Biological;Biopsy;Blood capillaries;blood pressure control;cell type;Cells;Cellular biology;Characteristics;Chronic Kidney Failure;Clinical;clinical phenotype;cohort;Collection;Computer Analysis;computerized tools;Data;Data Analyses;data integration;Data Science;Data Set;Digestion;digital;Disease;disease heterogeneity;disorder subtype;Distal;Duct (organ) structure;Elements;Environment;experience;experimental study;extracellular;Filtration;Heterogeneity;Homeostasis;Human;Human BioMolecular Atlas Program;human imaging;Image;Image Analysis;image registration;imaging facilities;imaging Segmentation;Individual;Infrastructure;injured;innovation;insight;interstitial;Kidney;kidney biopsy;kidney cell;Kidney Diseases;kidney imaging;Knowledge;Label;Laboratories;laser capture microdissection;Learning;Link;Lipids;Lymphatic;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Messenger RNA;Microscopy;Mission;Modality;Molecular;Molecular Analysis;molecular imaging;Molecular Profiling;Morphology;multimodal data;Multimodal Imaging;multimodality;multiple omics;nano-string;Neighborhoods;Nephrology;Nephrons;next generation sequencing;Pathology;Pathway interactions;patient population;Patients;Performance;potential biomarker;precision medicine;Process;Proteins;Proteomics;Protocols documentation;Race;Research;Research Personnel;Resolution;Resources;Sampling;sex;Site;Sodium Chloride;spatial integration;spatial relationship;specific biomarkers;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stains;Structure;supervised learning;Surface;Technology;Therapeutic Intervention;Tissue atlas;Tissues;transcriptomics;Translating;Tubular formation;Universities;unsupervised learning;Validation;Water

PROJECT_TITLE: Multimodal Imaging Mass Spectrometry and Spatial Omics for the Human Kidney


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: MARSHFIELD

ORG_NAME: MARSHFIELD CLINIC RESEARCH FOUNDATION

ORG_STATE: WI

PHR: PROJECT NARRATIVE WiNCORP represents a collaborative effort among three healthcare systems that provide oncology care to a predominantly rural population in Wisconsin, the Upper Peninsula of Michigan, Northeastern Iowa, and Southeastern Minnesota. Member sites have developed multidisciplinary care teams and research staff to accrue numerous patients to NCI-sponsored trials and encourage collaboration through participation in regional research networks and affiliations with academic medical centers. WiNCORP will continue to provide patient access to NCI-sponsored clinical trials and influence oncology practice patterns in the region through the conduct and publication of cancer care delivery research (CCDR) projects.

PI_NAMEs: OETTEL, KURT ;ONITILO, ADEDAYO A (contact);WEISS, MATTHIAS

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Academic Medical Centers;Advisory Committees;Aftercare;Agreement;American College of Radiology Imaging Network;American College of Surgeons Oncology Group;Area;base;Basic Science;Cancer Burden;cancer care;Cancer Center;cancer clinical trial;cancer health disparity;cancer prevention;care delivery;Caring;Clinic;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communication;Community Clinical Oncology Program;community engagement;Community Outreach;Conduct Clinical Trials;County;Development;disparity reduction;Eastern Cooperative Oncology Group;Education;Elderly;feasibility trial;Geography;Goals;Grant;Health Service Area;Health system;Healthcare Systems;Hospitals;Human Resources;Image;improved;Infrastructure;Institution;Integrated Health Care Systems;Iowa;Leadership;Low Income Population;member;Michigan;Minnesota;Mission;Molecular Target;multidisciplinary;North Central Cancer Treatment Group;Oncology;Operative Surgical Procedures;participant enrollment;Patient Care;patient population;Patients;Pattern;Phase;Physicians;Positioning Attribute;Prevention;Procedures;Process;programs;Provider;Publications;Quality of life;Recording of previous events;Research;Research Infrastructure;Research Personnel;Research Project Grants;research study;Resource Sharing;Rural;rural area;Rural Population;screening;Screening for cancer;Services;Site;survivorship;symptom management;Symptoms;synergism;System;Systems Development;Translational Research;Underrepresented Populations;Wisconsin;Work

PROJECT_TITLE: Wisconsin NCI Community Oncology Research Program (WiNCORP)


NIH_SPENDING_CATS: HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This project will develop a new type of mathematical model, which could be used in any country in Sub-Saharan Africa to identify geographic disparities in the opportunity for people living with HIV (PLHIV) to access antiretroviral treatment (ART), and then to determine optimal strategies for reducing these disparities. We will demonstrate the utility of the model by analyzing a series of datasets from Malawi, a low-income country with one of the most severe HIV epidemics in the world. In doing so we will help advance UNAIDS’ 2021-2026 global strategy, which emphasizes the application of novel, data-driven approaches for achieving a more equitable access to HIV interventions.

PI_NAMEs: BLOWER, SALLY MARGARET (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: access disparities;Acquired Immunodeficiency Syndrome;Adopted;Africa;Africa South of the Sahara;African;antiretroviral therapy;Area;Caring;Collaborations;Country;COVID-19;Data;Data Set;design;Disparity;disparity reduction;Economics;Epidemic;Equity;Face;geographic disparity;Geographic Distribution;Geography;Health;Health care facility;Health Resources;Healthcare;Healthcare Systems;HIV;Incidence;Individual;Inequality;Interruption;Intervention;Location;low income country;Malawi;mathematical model;Methods;model design;Modeling;novel;Pattern;Persons;Population;population based;Prevalence;Process;programs;Sampling;Science;Series;Spatial Distribution;Surveys;theories;tool;Travel

PROJECT_TITLE: Using geospatial science to maximize the opportunity to access ART in Africa


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: WINSTON-SALEM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Understanding the brain processes underlying alcohol use and misuse are essential for the development of effective treatments for alcohol use disorder or AUD. The current proposal will develop new methodologies to examine functional brain networks in humans. The networks will then be used to identify critical brain circuits that are predictive of future alcohol consumption.

PI_NAMEs: BOLLT, ERIK ;LAURIENTI, PAUL  (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Adolescence;Alcohol consumption;alcohol misuse;alcohol use disorder;Alcohols;Area;Biological;Brain;Brain Diseases;brain dysfunction;Brain imaging;Brain region;Clinical Research;Cognitive;Coin;cooperative study;Data;Data Set;design;Development;Diagnosis;drinking behavior;dynamic system;effective therapy;Etiology;flexibility;Formulation;Functional Imaging;Future;Human;Knowledge;Maps;Mathematical Model Simulation;Mathematics;Methodology;Methods;neural;neurodevelopment;neuroimaging;Neurosciences;novel diagnostics;novel therapeutic intervention;Participant;Patient Care;Play;potential biomarker;Principal Investigator;Process;programs;Reproducibility;Rest;Role;Science;Series;success;targeted therapy trials;Time;underage drinking;Work

PROJECT_TITLE: CRCNS: Functional Brain Networks with Tensioned Stability for Optimal Processing


ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Multiple organ dysfunction syndrome (MODS) affects as many 57% of critically ill children, with mortality rates as high 67% among those infected. Infectious outcomes are affected by the host immune response and timely, effective antibiotic strategies; however the modification of antibiotic management strategies as a function of both MODS and host immune paralysis (IP) are key knowledge gaps in pediatric MODS. By leveraging the PARADIGM study infrastructure (R01HD095976), the objectives of this application are to characterize the variability of concentrations for the antibiotics most commonly used in pediatric MODS; to investigate the relationships between antibiotic target attainment and outcomes in pediatric MODS with and without IP; to develop model-based dosing approaches that rapidly achieve and maintain target antibiotic concentrations.

PI_NAMEs: DOWNES, KEVIN JAMES (contact);SCHEETZ, MARC HOWARD

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;adverse outcome;Affect;Antibiotic Therapy;Antibiotics;Bacterial Infections;beta-Lactams;Biological Assay;Biological Markers;Blood;Cessation of life;Child;Childhood;Clinical;Clinical Data;Clinical Trials;Critically ill children;Data;Death Rate;Decision Trees;Development;Dose;Drug Kinetics;Drug Monitoring;Effectiveness;Enrollment;Epidemiologic Factors;Functional disorder;Funding;Future;Goals;high risk population;Hour;immune function;Immune response;Immune Tolerance;Immunocompetent;immunological status;improved outcome;Infection;Infrastructure;Intervention;Kidney;Knowledge;Laboratories;Measures;Modeling;models and simulation;Modification;Morbidity - disease rate;mortality;mortality risk;Multiple Organ Failure;National Institute of Child Health and Human Development;Nosocomial Infections;Organ;Organ failure;Outcome;Pediatric Intensive Care Units;pediatric pharmacology;pediatric sepsis;pharmacokinetic model;Physiology;Population;Prospective Studies;Publishing;Qualifying;Research;Risk Factors;Sampling;simulation;Source;Strategic Planning;Therapeutic;therapeutically effective;Time;tool;Toxic effect;trial comparing;United States National Institutes of Health;Vancomycin;Weight

PROJECT_TITLE: Assessment of MODS and Personalized Exposures of Antibiotics

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Conservative in situ management is a promising alternative treatment to hysterectomy for patients with placenta accreta spectrum and may be safer and preferable for some patients. The proposed research will evaluate the feasibility of a future randomized clinical trial comparing these treatments and provide novel data to inform shared decision-making and cost-effective care for patients with this deadly pregnancy disorder.

PI_NAMEs: EINERSON, BRETT DAVID (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Address;alternative treatment;Award;barrier to care;Benefits and Risks;career;career development;Caring;Clinical;Clinical Treatment;Clinical Trials;Clinical Trials Design;Cohort Studies;Complex;Control Groups;cost;cost comparison;cost effective;cost effective treatment;Counseling;Data;Decision Aid;Decision Making;design;Discipline of obstetrics;Disease;Economic Burden;economic evaluation;Economics;Eligibility Determination;Enrollment;evidence base;follow-up;Foundations;Frustration;Funding;Future;Goals;Health;health economics;Healthcare Systems;Hemorrhage;Hysterectomy;improved;In Situ;Incidence;Infertility;International;Interview;Knowledge;Leadership;Left;Maternal-fetal medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Monitor;Morbidity - disease rate;mortality;Needs Assessment;Neonatal;novel;Operative Surgical Procedures;Outcome;Patient Care;patient oriented;Patient Outcomes Assessments;Patients;Physicians;pilot trial;Placenta;Placenta Accreta;Placental Necrosis;Positioning Attribute;preference;Pregnancy;pregnancy disorder;premature;Principal Investigator;Process;Qualitative Methods;Qualitative Research;Quality of life;Randomized;randomized, clinical trials;Repeat Surgery;Research;Research Design;Research Ethics;Research Personnel;Risk;Safety;Scientist;severe maternal morbidity;shared decision making;Silver;skills;standard care;Structure;Therapeutic;Time;treatment comparison;trial comparing;trophoblast;United States National Institutes of Health;Universities;Utah;Uterus;Woman;Work

PROJECT_TITLE: Conservative management as an alternative to hysterectomy for placenta accreta spectrum.

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


NIH_SPENDING_CATS: Clinical Research;Emergency Care;Hematology;Infectious Diseases;Sepsis

PHR: PROJECT NARRATIVE Sepsis is a severe infection defined by a dysregulated immune response and organ dysfunction that causes significant morbidity and mortality worldwide, despite decades of research. Necroinflammatory cell death is an important mechanism in the initiation of the innate immune and organ dysfunction in sepsis. This project aims to evaluate novel necroinflammatory cell death biomarkers in early sepsis and track their change, with the ultimate goal of establishing necroinflammatory subphenotypes in sepsis.

PI_NAMEs: SCHENCK, EDWARD JAMES (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Accident and Emergency department;Acute;Admission activity;Affect;antimicrobial;Apoptosis;Area;Benign;biobank;Biological Markers;biomarker development;biomarker panel;Blood;Body System;Cell Death;Cell Death Process;Cell Physiology;Cells;Circulation;Clinical;Clinical Trials;cohort;Complex;cytokine;Data;Development;Diagnosis;Emergency Department patient;Enrollment;Epithelial Cells;follow-up;Functional disorder;Goals;Heterogeneity;HMGB1 gene;Hospitals;Human;Immune;Immune response;Immune system;Immunologic Stimulation;Immunologics;immunomodulatory therapies;Immunotherapy;improved;Induction of Apoptosis;Infection;Inflammation;Inflammatory;Innate Immune Response;Innate Immune System;insight;Intensive Care Units;Ligands;Measures;member;Methodology;Mitochondrial DNA;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;mortality risk;novel;Organ;Organ failure;Outcome;pathogen;Pathogenesis;Pathway interactions;Patients;Pattern;Phenotype;Physiological;Plasma;predictive marker;predictive tools;Production;Protein-Serine-Threonine Kinases;Proteomics;prototype;receptor;recruit;Research;Resuscitation;RIPK1 gene;RIPK3 gene;Risk;Role;sample collection;Sepsis;septic patients;Septic Shock;Serine;Severities;Syndrome;Testing;Time;TNF gene;TNF-related apoptosis-inducing ligand;treatment effect;Treatment Factor;ward;Work

PROJECT_TITLE: Necroinflammatory Cell Death in Sepsis

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PITTSBURGH

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative: Overall The mission of the UPMC Hillman Cancer Center (HCC) is to reduce the burden of cancer in western Pennsylvania and the nation through research, patient care, education and outreach. Since its founding in 1985, HCC has been at the forefront in discovery and advancement of scientific findings that have led to new strategies for preventing, detecting, diagnosing, and treating cancer, and for addressing the health-related needs and well-being of cancer patients and survivors.

PI_NAMEs: SCHMITZ, KATHRYN H. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Address;Adult;Aging;anti-cancer research;Appointment;Area;Articulation;Basic Science;biobehavior;Bioinformatics;Caliber;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer epidemiology;cancer genomics;cancer health disparity;cancer immunotherapy;Cancer Patient;cancer prevention;Cancer Survivor;Catchment Area;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communication;community advisory board;community engagement;Community Networks;Community Outreach;Consent;cost effective;County;Cyclic GMP;Databases;Decision Making;Dedications;Development;Diagnosis;Disadvantaged;Disease;Disparity;Doctor of Philosophy;early-career faculty;Education;Education and Outreach;Educational Status;Enrollment;Ensure;Environmental Risk Factor;Equipment;Evaluation;experience;Faculty;Faculty Recruitment;faculty support;Funding;Future;Genome Stability;Genomic medicine;Goals;Health;health equity;Healthcare Systems;high school;High-Throughput Nucleotide Sequencing;Immune;Immunologic Monitoring;improved;Infrastructure;Institution;Intervention;Investments;Laboratories;Leadership;Learning;Malignant Neoplasms;member;Mission;Modality;National Cancer Institute;operation;organizational structure;Patient Care;pediatric patients;peer;Pennsylvania;Personal Satisfaction;Philanthropic Fund;Population;Population Sciences;population survey;precision medicine;prevent;Process;programs;Protocols documentation;Publications;Publishing;Recommendation;recruit;Research;Research Personnel;Resource Sharing;Risk;rural dwellers;Science;Scientific Advances and Accomplishments;Services;Site;Source;Strategic Planning;Therapeutic;Time;Training;Training and Education;Translational Research;Transplantation;tumor;tumor immunology;Underrepresented Minority;United States National Institutes of Health;Universities;University resources;Update;urban minority;virology;Vision

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention

ORG_CITY: NEWARK

ORG_NAME: CHRISTIANA CARE HEALTH SERVICES, INC.

ORG_STATE: DE

PHR: Project Narrative Our mission statement is to provide the community with coordinated access to National Cancer Institute sponsored clinical trials and Cancer Care Delivery Research in order to reduce cancer incidence, morbidity and mortality while improving quality of life. Participation in the NCORP provides us with the opportunity to work towards our mission.

PI_NAMEs: MASTERS, GREGORY A (contact)

PROJECT_TERMS: Address;Advisory Committees;Advocate;Affect;Aftercare;American College of Radiology Imaging Network;American Society of Clinical Oncology;Appointment;Area;base;Breast;cancer care;Cancer Center;cancer clinical trial;Cancer Control;Cancer Control Research;cancer health disparity;cancer prevention;cancer therapy;care coordination;care costs;care delivery;Caring;Catchment Area;Clinical Research;Clinical Treatment;Clinical Trials;Collaborations;Communities;Community Clinical Oncology Program;community engagement;Community Hospitals;Conduct Clinical Trials;cost;data management;data quality;Dedications;Delaware;Development;early phase trial;Eastern Cooperative Oncology Group;Enrollment;Ensure;Evidence based practice;expectation;Financial cost;Funding;Genetic Counseling;Goals;Grant;Gynecologic;health care service organization;Health Technology;Healthcare;Image;improved;Incidence;Individual;Investigation;Investigational Drugs;Leadership;Malignant Neoplasms;Maryland;member;Minority;Minority Outreach Program;Mission;Morbidity - disease rate;mortality;multidisciplinary;National Cancer Institute;National Cancer Program;National Clinical Trials Network;NCI Center for Cancer Research;New Jersey;Oncologist;Oncology;organizational structure;Palliative Care;Participant;patient engagement;Patients;Pennsylvania;Persons;Physicians;Positioning Attribute;Prevention;Principal Investigator;Process;Program Evaluation;programs;protocol development;Protocols documentation;quality assurance;Quality of Care;Quality of life;Rare Diseases;Research;Research Design;Research Institute;Research Personnel;Resources;routine care;screening;social factors;technology platform;Travel;treatment trial;trial enrollment;Tumor Bank;Underrepresented Populations;Underserved Population;uptake;Work

PROJECT_TITLE: Delaware Christiana Care NCORP


PI_NAMEs: FERRIS, ROBERT L. (contact)

PROJECT_TERMS: anti-cancer research;Award;Basic Science;Budgets;Cancer Center;Cancer Center Support Grant;cancer research center director;Catchment Area;Chad;Clinical Research;Collaborations;Communication;Communities;Comprehensive Cancer Center;computer network;Contracts;cost;County;Data;data resource;Development;Doctor of Philosophy;Education;Education and Outreach;Ensure;Equipment;Evaluation;Faculty;Faculty Recruitment;Fostering;Funding;Funding Opportunities;Grant;Healthcare;Human Resources;Informatics;Information Technology;Infrastructure;Institution;Leadership;Malignant Neoplasms;Marketing;meetings;member;microbiome;Mission;Monitor;multidisciplinary;National Cancer Institute;NCI Center for Cancer Research;Newsletter;Office of Administrative Management;Output;outreach;Pennsylvania;Play;Population Research;population survey;Process;Productivity;programs;Publications;Recommendation;recruit;Reporting;Research;Resource Sharing;Role;Schools;Science;Services;State Government;Strategic Planning;Surveys;Translational Research;Travel;United States National Institutes of Health;Universities;University resources;Wages;web site

PROJECT_TITLE: Cancer Center Administration


PI_NAMEs: BAKKENIST, CHRISTOPHER J. (contact)

PROJECT_TERMS: Academy;Accountability;anti-cancer research;Appointment;Award;Biology;Biomedical Research;cancer care;Cancer Center;Cancer Center Support Grant;cancer education;Cancer Research Project;cancer therapy;career;career development;Career Mobility;Catchment Area;Clinical;college;Communities;computer science;design;Disadvantaged;disadvantaged student;doctoral student;Education;education research;Educational Activities;Educational workshop;Effectiveness;Enrollment;Ensure;Equity;experience;Faculty;faculty mentor;Foundations;Funding;Future;Goals;Government;graduate student;Grant;Growth;Health Personnel;high school;High School Student;improved;Industry;Informatics;innovation;Internships;Investments;Journals;Leadership;literacy;Malignant Neoplasms;Medical Students;Mentors;Mentorship;next generation;Nurse Practitioners;Physician Assistants;Population;Positioning Attribute;Postdoctoral Fellow;programs;Publishing;racism;recruit;Research Personnel;Science;Strategic Planning;Students;Study Section;success;summer internship;Training;Training and Education;training opportunity;Training Programs;Translational Research;Travel;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;Universities;Wages;Work;Writing

PROJECT_TITLE: Cancer Research Career Enhancement and Related Activities


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Mental Health;Multiple Sclerosis;Neurodegenerative;Neurosciences;Physical Activity;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: People with multiple sclerosis (MS) commonly experience problems with cognitive function, but current assessment methods only provide a “snapshot” of cognition and fail to capture its true nature where it matters most, in daily life. The proposed research will examine the utility of novel mobile app-based cognitive tests to characterize changes in cognitive function, while simultaneously collecting data on important modifiable factors (e.g., physical activity, sleep, fatigue) that may impact cognitive function. Better understanding of daily variability in cognitive function, predictors of cognitive decline and the impact of cognitive dysfunction is crucial to developing treatments that can improve the functioning and health-related quality of life of people with MS.

PI_NAMEs: FRITZ, NORA E.;KRATZ, ANNA LOUISE (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Accelerometer;Address;Affect;Attention;Autoimmune Diseases;Behavioral;Brain Diseases;Caring;Central Nervous System Diseases;Characteristics;Chronic;Chronic Disease;Clinic;Cognition;cognitive ability;cognitive change;cognitive function;cognitive performance;cognitive testing;Data;design;Detection;Development;Dimensions;disability;Ecological momentary assessment;Employment;Environment;Episodic memory;executive function;experience;Fatigue;follow-up;functional improvement;Future;Grain;Health Psychology;health related quality of life;Impaired cognition;improved;Independent Living;Individual;Inflammatory;innovation;Intervention;Knowledge;Life;Link;Measurement;Measures;Medical;medical specialties;Memory;Methods;mobile application;Moods;Multiple Sclerosis;multiple sclerosis patient;Natural History;Nature;neurocognitive test;neurological rehabilitation;Neurology;Neuropsychology;novel;Outcome;Pain;patient oriented;Patient Self-Report;person centered;Persons;Physical activity;Physical Function;Physical therapy;processing speed;Productivity;prognostic value;Protocols documentation;Reporting;Research;restorative treatment;Short-Term Memory;Sleep;smartphone application;social engagement;Social Functioning;Social outcome;Spinal Diseases;Statistical Data Interpretation;Stress;Symptoms;Techniques;Technology;Testing;Time;treatment adherence;verbal;visual memory;Work;young adult

PROJECT_TITLE: Optimizing detection and prediction of changes in cognitive function in multiple sclerosis with novel ambulatory assessment methods

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


PI_NAMEs: NEWSOME, JOSEPH T (contact)

PROJECT_TERMS: animal care;Animal Experimentation;animal facility;Animal Housing;animal imaging;Animal Model;Animals;Biological Markers;Biological Process;Biomedical Research;Breeding;Budgets;Cancer Center;Cancer Center Support Grant;cancer prevention;cancer therapy;Case Management;Cells;Cessation of life;Charge;chemotherapeutic agent;Collaborations;Communities;Comparative Pathology;Consultations;cost;Day Care;Dedications;density;design;Development;Diagnostic;Education;Educational process of instructing;Effectiveness of Interventions;effectiveness study;Effector Cell;Electronics;Equipment;Equipment and supply inventories;Event;Expenditure;experience;Funding;gene therapy;germ free condition;Gnotobiotic;Goals;Grant;Health;Housing;Human Microbiome;Human Resources;IACUC;Imaging Device;Immune;In Vitro;in vivo;in vivo Model;Individual;Investigation;Malignant Neoplasms;Measures;Medical Records;meetings;member;Methodology;microbiome research;Modality;Molecular;Mus;NCI Center for Cancer Research;novel;Online Systems;Pathologic;Pathologist;pharmacologic;Phenotype;pre-clinical;Pre-Clinical Model;Preventive measure;Procedures;programs;Protocols documentation;Rattus;Recommendation;recruit;Reporting;Reproducibility;Research;research clinical testing;research facility;Research Personnel;Resource Sharing;Resources;Services;Shrews;single molecule;square foot;System;Testing;Therapeutic;Tissues;Training;Transgenic Organisms;Translational Research;tumor;Tumor Burden;tumor microenvironment;tumor progression;Validation;ventilation

PROJECT_TITLE: Animal Facility


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence

PI_NAMEs: NORMOLLE, DANIEL P (contact)

PROJECT_TERMS: Achievement;anti-cancer research;Applications Grants;bench to bedside;biobehavior;Bioinformatics;Biological Assay;Biological Markers;Biometry;Budgets;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer epidemiology;cancer genome;cancer immunotherapy;cancer prevention;clinical center;Clinical Research;clinical trial analysis;clinical trial protocol;Clinical Trials;Clinical Trials Design;Computers;Conduct Clinical Trials;Data;Data Analyses;Dedications;design;Development;Diagnostic;Disease;DNA sequencing;Education;Ensure;Epidemiologist;Experimental Designs;experimental study;Faculty;Faculty Recruitment;Foundations;Funding;Genetic Transcription;Genotype;Human Resources;Immunoassay;in vivo;Knowledge;Laboratories;Letters;Literature;Machine Learning;machine learning method;Malignant Neoplasms;Manuscripts;medical specialties;meetings;member;Methods;Monitor;multidimensional data;novel;Observational Study;Paper;Peer Review;Population Programs;posters;pre-clinical;pre-clinical research;precision medicine;Principal Investigator;programs;Proteomics;Reporting;Research;Research Personnel;Resource Sharing;Services;Statistical Data Interpretation;Statistical Methods;Technology;Therapeutic;tool;transcriptome sequencing;Translational Research;tumor immunology;United States Dept. of Health and Human Services;virology;Work

PROJECT_TITLE: Biostatistics Facility


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: PROJECT NARRATIVE. The goal of the proposed research is to use mass spectrometry-based methods to characterize proteomes in neuron and organoid models of Rett syndrome and CNV 16p11.2 genotypes that are on the Autism Spectrum.

PI_NAMEs: MUOTRI, ALYSSON R.;YATES III, JOHN R (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: 16p11.2;Action Potentials;Age;autism onset;autism spectrum disorder;Biochemical;Brain;Brain Diseases;Cell Communication;cell cortex;Cell model;Cells;Cerebrum;clinical phenotype;Copy Number Polymorphism;Data;data acquisition;Development;Devices;Disease;Electrophysiology (science);Elements;Exhibits;experimental study;Family;Fetal Development;Fibroblasts;Gene Dosage;Genes;Genetic;Genetic Models;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;Genotype;genotyped patients;Goals;Human;human disease;human induced pluripotent stem cells;in vitro Model;Individual;Individual Differences;induced pluripotent stem cell;Libraries;Mass Spectrum Analysis;Measurement;Measures;Methods;Methyl-CpG-Binding Protein 2;Microelectrodes;Modeling;Molecular;Morphology;mutant;Mutation;nerve stem cell;Neurons;Organoids;Outcome;patch clamp;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phenotype;Phosphoproteins;Procedures;Process;Process Measure;process optimization;programs;Proteins;Proteome;Proteomics;Recording of previous events;Research;Rett Syndrome;Role;Sampling;Skin;Technology;Twin Studies

PROJECT_TITLE: Proteogenetics of Autism Spectrum Disorders

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Cancer incidence is expected to increase to 23.6 million by 2030 worldwide, and cancer is the leading cause of death for Asian Americans whose numbers are rapidly rising to reach 40 million by 2050. Despite instances of greater cancer-specific mortality compared to other Asians and likely limited access to high-quality care due many experiencing language barriers (~50%), very little is known about supportive care needs in Chinese-, Vietnamese-, and Korean-Americans with metastatic cancers. This project will fill a critical gap in our understanding, and develop culturally relevant and scalable psychosocial resources aimed at improving the quality of life of Chinese-, Vietnamese-, and Korean-Americans with metastatic cancers.

PI_NAMEs: KIM, JACQUELINE H. J. (contact)

PROGRAM_OFFICER_NAME: ACEVEDO, AMANDA MARIE

PROJECT_TERMS: active method;Adult;Advocacy;Agreement;American;Area;Asian;Asian Americans;Asian population;Behavioral;California;cancer care;Cancer Control;Cancer Etiology;Cancer Patient;cancer survival;care delivery;care outcomes;career;Caregivers;Caring;Cause of Death;Chinese;Collaborations;Communication;Competence;coping;cultural values;Data;demographics;design;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;Early Diagnosis;East Asian;Emotions;Ethnic Population;experience;Faculty;Family;Focus Groups;Fostering;Functional impairment;Future;Goals;Guidelines;Hispanic;Immigrant;improved;improved outcome;Incidence;informant;innovation;Intervention;Interview;Knowledge;Korean American;Koreans;Language;Latinx;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;Mentorship;Methods;Modality;mortality;Not Hispanic or Latino;Oncology;Outcome;Participant;Patient Outcomes Assessments;Patients;Persons;Phase;Philosophy;Population;Positioning Attribute;preference;Process;Provider;psychosocial;psychosocial resources;Qualifying;Quality of Care;Quality of life;Randomized, Controlled Trials;Research;Research Methodology;Research Personnel;Resource Development;Resources;response;skills;social;southeast Asian;Structure;Supportive care;Surveys;Survival Rate;survivorship;Symptoms;tenure track;Testing;therapy development;Training;Vietnamese;Work;Writing

PROJECT_TITLE: Supportive Care Needs in Asian Americans with Metastatic Cancer


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Women's Health Research

PI_NAMEs: BAO, RIYUE  (contact)

PROJECT_TERMS: Agreement;anti-cancer research;ATAC-seq;Attention;Award;Big Data;Bioinformatics;biomedical informatics;Biometry;Budgets;Cancer Center;Cancer Center Support Grant;cancer genome;cancer genomics;Cells;ChIP-seq;Collaborations;computer infrastructure;cost;cost effective;Custom;Data;Data Analyses;Data Coordinating Center;data integration;data mining;data privacy;Data Science;data sharing;Data Sources;Development;DNA methylation profiling;Educational process of instructing;Ensure;exome;Faculty;Foundations;Funding;genome resource;genome sequencing;genomic data;genomic profiling;Genomics;Health;Health Science Library;High Performance Computing;Hour;Immunogenetics;Individual;informatics tool;Infrastructure;Institution;Internet;Laboratories;machine learning algorithm;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;member;Metadata;Metagenomics;Metastatic breast cancer;microbiome;microbiome analysis;Molecular Biology;Pathology;Play;Policies;Postdoctoral Fellow;precision medicine;predictive marker;Process;recruit;repository;Reproducibility;Research;Research Personnel;Resource Sharing;Role;Services;Shotguns;single-cell RNA sequencing;Skin Cancer;Specialized Program of Research Excellence;Specimen;Students;Supercomputing;System;The Cancer Genome Atlas;Tissues;tool;transcriptome sequencing;transcriptomics;Universities;variant detection;whole genome;Work

PROJECT_TITLE: Cancer Bioinformatics Services


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

PI_NAMEs: NIKIFOROV, YURI E (contact)

PROJECT_TERMS: Basic Science;biobank;Bioinformatics;Biological Assay;Biometry;Budgets;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer genomics;CLIA certified;Clinical;Clinical Research;cloud storage;Collaborations;Complex;Consultations;cost;cost effective;Data;Data Analyses;Detection;Diagnostic;DNA Repository;DNA sequencing;epigenomics;exome;exome sequencing;Experimental Designs;foot;Formalin;Freezing;Funding;gene therapy;Genes;Genome;genome sequencing;Genomics;Genotype;Glioma;Goals;Hematologic Neoplasms;High-Throughput Nucleotide Sequencing;Immunogenomics;Immunotherapy;improved;Individual;Informatics;instrumentation;Laboratories;Libraries;Malignant neoplasm of pancreas;Malignant Neoplasms;member;Methylation;Molecular;next generation sequencing;Nucleic Acids;Oncology;Paraffin Embedding;Pathology;Phase;Precision cancer therapy;precision medicine;Process;prognostic;Research;Research Personnel;research study;Resources;RNA;Robotics;Sampling;Services;single cell genomics;single cell sequencing;single-cell RNA sequencing;skills;Solid Neoplasm;System;Techniques;Technology;Testing;Thyroid Gland;Time;Tissue Banks;Tissue Embedding;Tissue Microarray;Tissue Sample;Tissues;Training and Education;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;tumor;Validation;Vision;whole genome

PROJECT_TITLE: Cancer Genomics Facility


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Nanotechnology;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse;Tobacco

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE Prenatal alcohol/ethanol and nicotine exposure (PEE/PNE) are common causal factors in the US and worldwide for fetal brain growth deficits, and their effects can be synergistic. The proposed research is relevant to public health because it provides a new method for understanding the impacts of maternal ethanol and nicotine consumption during pregnancy on the mammalian brain and microvasculature development. The proposed research is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge that will reduce the burdens of human disability, in this case, due to exposure to toxins during gestation.

PI_NAMEs: LARIN, KIRILL V (contact);LARINA, IRINA ;MIRANDA, RAJESH C

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: 3-Dimensional;Acute;Adhesions;Adult;Alcohol consumption;alcohol exposure;Alcohols;Algorithms;angiogenesis;Animals;Arteries;Attenuated;Behavior;Blood;Blood - brain barrier anatomy;Blood capillaries;Blood flow;blood vessel development;Blood Vessels;Brain;Brain region;Capillary Permeability;Cell Count;cell motility;Cells;Cephalic;cerebral capillary;cerebral microvasculature;Cerebrovascular system;Circulation;Companions;Complex;computerized data processing;critical period;Data;Development;disability;efficacy evaluation;Embryo;Endothelial Cells;Endothelium;Ethanol;Etiology;Exposure to;Fenestrated Capillary;fetal;Fetal Alcohol Exposure;fetal stem cell;Fetus;Fluorescence;Fluorescence Microscopy;Funding;Growth;Hemorrhage;high resolution imaging;Human;Image;Imaging Device;imaging platform;Imaging technology;Immune;in utero;Individual;Infiltration;Inflammation Mediators;Inflammatory;innovation;instrument;Interleukin-12;interleukin-21;Intervention;intravital imaging;Invaded;Knowledge;Leptomeninges;Light;Link;macromolecule;Maternal Exposure;Mediating;meter;Methods;Microglia;Microscopy;middle cerebral artery;migration;Mission;Modeling;Molecular;monocyte;Multi-modal optical imaging;Multimodal Imaging;Mus;nanoparticle;nerve stem cell;neurogenesis;neuroregulation;new technology;Nicotine;nicotine exposure;nicotine use;novel;nutrition;Optical Coherence Tomography;optical imaging;Peer Review;Penetration;perineural;Peripheral;Permeability;Pharmaceutical Preparations;pharmacologic;Physiological;Physiology;polysubstance use;Positioning Attribute;pre-clinical;Pregnancy;prenatal;prenatal nicotine exposure;prevent;Proteins;Public Health;Publications;Publishing;Reporter;Reporting;Research;Residual state;Resolution;response;Sampling;Specificity;stem cell niche;stem cell proliferation;structural imaging;Structure;Surface;symposium;systemic inflammatory response;Teratogens;Testing;Time;tool;Toxin;trafficking;Transgenic Mice;two-photon;United States National Institutes of Health;Uterus;Vascular blood supply;Vascular Permeabilities;Ventricular;Ventricular Function;Visualization

PROJECT_TITLE: Multimodal Optical Imaging on the Effect of Maternal Polysubstance Exposure on Fetal Brain Microvessel Function


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_STATE: NC

PHR: The Wake Forest NCORP Research Base develops and implements multi-site Cancer Control and Cancer Care Delivery (CCDR) clinical research studies in partnership with NCORP Community and Minority/Underserved Community Sites to improve patient well-being and the quality of cancer care.

PI_NAMEs: DRESSLER, EMILY VAN METER;LESSER, GLENN J (contact);WEAVER, KATHRYN ELIZABETH

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Acceleration;Address;Age;Aging;Area;base;Behavioral Sciences;biobank;Biological;Biometry;Blood;cancer care;cancer complication;Cancer Control;cancer health disparity;cancer site;cancer therapy;Cardiology;Cardiovascular system;care delivery;care systems;Caregivers;Caring;chemotherapy;Chemotherapy and/or radiation;clinical investigation;Clinical Research;Collaborations;Collection;Communities;Community Clinical Oncology Program;community partners;Comprehensive Cancer Center;Country;Data;Development;Disparity;Dissemination and Implementation;Early treatment;early-career faculty;Enrollment;ethnic minority;ethnic minority population;evidence base;Faculty;Family;Funding;Future;Goals;health disparity;Health Sciences;Health Services Research;Image;improved;Individual;Infrastructure;innovation;Interdisciplinary Study;Intervention;Investigation;knowledge translation;Late Effects;Liquid substance;Malignant Neoplasms;medical schools;Mentors;Minority;multidisciplinary;NCI Center for Cancer Research;NCI-Designated Cancer Center;Neurocognitive;Neurosciences;next generation;novel;Oncology;Outcome;Participant;patient oriented;patient population;Patients;Personal Satisfaction;Postdoctoral Fellow;Prevention;Primary Care;Process;protocol development;Protocols documentation;Public Health;racial minority;Radiation therapy;recruit;Research;Research Activity;Research Design;Research Personnel;research study;Resources;rural dwellers;Salivary;Sampling;Science;Site;Specimen;Students;Supportive care;survivorship;Symptoms;Toxic effect;Training;Treatment Efficacy;Treatment outcome;underserved community;underserved minority;Underserved Population;Urine;Woman

PROJECT_TITLE: Wake Forest NCORP Research Base


NIH_SPENDING_CATS: Cancer

PI_NAMEs: BEUMER, JAN HENDRIK (contact)

PROJECT_TERMS: absorption;Adopted;Advisory Committees;Antineoplastic Agents;Award;Biological Assay;Budgets;Cancer Center;Cancer Center Support Grant;Capital;Cells;Clinical;Clinical Pharmacology;Clinical Trials;Clinical Trials Network;Communities;Data;Data Analyses;Development;DNA Damage;drug development;Drug Kinetics;early phase clinical trial;Early Therapeutic-Clinical Trials Network;Ensure;Equipment;Exclusion;experience;Exposure to;Funding;High Pressure Liquid Chromatography;Human Resources;Hybrids;Injections;instrumentation;Investments;Ions;Joints;Label;Lead;Liquid substance;Malignant Neoplasms;Measures;Medicine;meetings;member;Methodology;Methods;mid-career faculty;NCI Center for Cancer Research;Nitrogen;novel;novel anticancer drug;Outcome;Peer Review Grants;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Substance;Pharmacology;Phase I Clinical Trials;Phase II Clinical Trials;Philosophy;Population;Power Sources;pre-clinical;Procedures;Process;professor;programs;Publications;Quality Control;Reader;Reagent;Research;Research Design;Research Personnel;Resource Sharing;Role;sample collection;Sampling;Science;Scientist;Scintillation Counter;Services;Site;skills;small molecule;Specialist;Therapeutic Studies;Training;Translational Research;Validation;Water

PROJECT_TITLE: Cancer Pharmacokinetics and Pharmacodynamics Facility