PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will determine how T cells are activated. T cells are the cells of the immune system that kill tumor cells and provide protection against viruses and bacteria. When T cells are mis-activated they can attack one’s own organs and cause autoimmunity. The results of our work will provide new ways to engineer T cells for better anti-tumor specificity as well as new ways to use drugs to counter over-activated or mis-activated T cells, thereby reducing inflammation and autoimmunity. This project supports the NIH’s mission and aligns with its high-priority effort to address critical current and future issues in public health.

PI_NAMEs: KRUMMEL, MATTHEW F (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Affinity;Agonist;Antibodies;Antigens;Area;Autoimmunity;Bacteria;Binding;Biology;Cancer Model;Cell membrane;Cell model;Cell Physiology;Cell Therapy;Cells;Cellular biology;cellular microvillus;chimeric antigen receptor;clinical efficacy;Competence;Discrimination;Disease;Drug usage;engineered T cells;Engineering;Event;Extinction;Future;Generations;Goals;Grant;Heart;human disease;human model;Image;Immune system;immunoengineering;immunological synapse;Immunology;improved;In Vitro;Individual;Inflammation;Integrins;interest;Ligand Binding;Ligands;Malignant Neoplasms;Measures;Mediating;Membrane;Membrane Biology;Membrane Fusion;Methods;migration;Mission;Modification;mouse model;Nature;neoplastic cell;Organ;Outcome;Output;PD-1/PD-L1;Phase;programmed cell death ligand 1;programmed cell death protein 1;programs;Public Health;receptor;Receptor Signaling;Research;Research Personnel;Role;Scanning;Series;Signal Pathway;Signal Transduction;Site;Specific qualifier value;Specificity;success;Surface;Synapses;System;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Time;transcription factor;tumor specificity;United States National Institutes of Health;Variant;Villous;Virus;Work;ZAP-70 Gene

PROJECT_TITLE: CONTROL OF T CELL SYNAPSE STABILIZATION AND SIGNALING

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Hematology;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Acute myeloid leukemia (AML) accounts for disproportionately high morbidity and mortality in the pediatric population; one-third of patients will relapse, many despite having no detectable disease after therapy by all clinically available assays. Our research will evaluate the predictive value for relapse of novel molecular modalities for measurable residual disease (MRD) detection in retrospective and prospective cohorts of pediatric AML patients. Through this work we will lay a foundation for more comprehensive MRD assessment in pediatric AML that will ultimately enhance relapse prediction and early intervention.

PI_NAMEs: WINTERS, AMANDA C (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Acute Myelocytic Leukemia;Adolescent and Young Adult;adolescent patient;Adult;Adult Acute Lymphocytic Leukemia;Adult Acute Myeloblastic Leukemia;Aftercare;Allogenic;American Society of Hematology;Area;assay development;Bioinformatics;Biological Assay;Biological Sciences;Bone Marrow;Bone Marrow Transplantation;burden of illness;career;Cause of Death;CBFA2T1 gene;chemotherapy;Child;Childhood;Childhood Acute Myeloid Leukemia;Chimerism;Clinical;Clinical Trials Design;cohort;Collaborations;Colorado;Custom;Data Analyses;design;Detection;Development;Diagnostic;digital;digital measure;Disease;Disease Marker;Disease Outcome;Disease remission;Early identification;Early Intervention;Environment;experience;Faculty;Flow Cytometry;Fostering;Foundations;Frequencies;Genes;Goals;Hematologic Neoplasms;high risk;improved;improved outcome;Incidence;Jordan;K-Series Research Career Programs;knowledge base;leukemia;Measurable;Measures;Medical;meetings;Mentors;Modality;Molecular;Monitor;Morbidity - disease rate;Morphology;mortality;Mutation;mutation assay;Mutation Detection;Myelogenous;Myeloid Leukemia;Myeloproliferative disease;next generation sequencing;novel;NPM1 gene;Observational Study;patient oriented research;Patients;Pediatric cohort;Pediatric Hospitals;Pediatric Oncologist;Pediatric Oncology Group;pediatric patients;Physicians;Population;post-transplant;pre-clinical;Predictive Value;prevent;Probability;prospective;Prospective cohort;rare variant;Relapse;relapse patients;relapse prediction;relapse risk;Research;research clinical testing;Residual Neoplasm;Resources;Retrospective cohort;RUNX1 gene;Sampling;Scientist;Stem cell transplant;success;Survival Rate;Technical Expertise;Technology;Testing;Time;tool;translational physician;Translational Research;Transplantation;tumor;Universities;Validation;Wages;Work

PROJECT_TITLE: Preclinical Validation of Personalized Molecular Assays for Measurable Residual Disease Monitoring in Pediatric AML

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The neurotransmitter dopamine is essential for central nervous system control of locomotor activity, cognition and reward mechanisms. As such, dopamine is involved in several neurodegenerative and neuropsychiatric disorders, such as Parkinson’s disease, schizophrenia, ADHD and drug addiction. Dopamine transporter (DAT) serves to terminate dopamine neurotransmission and is a principal target of cocaine, methylphenidate and amphetamines. Revealing the components and processes that regulate DAT in intact brain as proposed in this application may lead to new strategies in the therapeutic intervention with drug addiction.

PI_NAMEs: SORKIN, ALEXANDER D (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Acute;Address;Affect;Amphetamines;Animals;Antibodies;Area;ascorbate;Attention deficit hyperactivity disorder;Axon;Binding;Biochemical;Biological Assay;Biotin;Brain;Brain region;Carrier Proteins;Cell membrane;Cells;Central Nervous System;Chemicals;Chimeric Proteins;Clathrin;Cocaine;Cognition;Complex;Corpus striatum structure;Coupling;Dependence;Dependovirus;Development;DLG4 gene;Dopamine;dopamine transporter;dopaminergic neuron;Dorsal;Down-Regulation;Drug Addiction;drug of abuse;Electron Microscopy;Endocytosis;Endocytosis Induction;Epitopes;experimental study;extracellular;Fluorescence;Generations;Goals;Gonadal Steroid Hormones;In Situ;in vivo;inhibitor;Injections;Kinetics;Knock-in Mouse;Label;Laboratories;male;Mass Spectrum Analysis;median forebrain bundle;Mediating;Membrane;Microscopy;Midbrain structure;Modeling;Molecular;Molecular Conformation;molecular mechanics;Morphology;Motor Activity;Mus;mutant;Nervous System control;Neurodegenerative Disorders;Neurons;neuropsychiatric disorder;neurotransmission;Neurotransmitters;novel;Nucleus Accumbens;Parkinson Disease;Pathway interactions;Peroxidases;Pharmaceutical Preparations;Positioning Attribute;Process;programs;protein activation;Protein Kinase C;protein protein interaction;Proteins;Proteome;psychostimulant;Regulation;Research;Resolution;response;reuptake;Rewards;Ritalin;RNA Interference;Schizophrenia;sex;Signal Transduction;Slice;small molecule;Specificity;stimulant abuse;Stimulus;Synaptic Membranes;System;temporal measurement;Tertiary Protein Structure;Testing;Therapeutic Intervention;Time;trafficking;Transgenic Mice;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Regulation of Dopamine Transporter by Trafficking

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Myotonic dystrophy is familial condition that causes muscle weakness and other problems. Currently there is no effective treatment, but many teams of drug developers are working to develop new therapies. This project is designed to create a laboratory measurement, called a biomarker, that is used to monitor whether a treatment is having beneficial effects, and speed up the process of making new treatments available.

PI_NAMEs: HAMEL, JOHANNA ;THORNTON, CHARLES A (contact)

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Address;Affect;Affinity;Agreement;Alternative Splicing;Animal Model;Ankle;Atrophic;biobank;Biological Assay;Biological Markers;biomarker driven;Biopsy Specimen;Cataract;Cessation of life;Clinical;clinical examination;Clinical Trials;cohort;compare effectiveness;CUG repeat;Defect;Degenerative Disorder;deltoid muscle;design;Detection;Development;disability;Disease;disease heterogeneity;Distal;Dose;Drug Approval;drug development;Drug Kinetics;early phase trial;effective therapy;Endosomes;Evaluation;Event;experience;Face;Frequencies;gain of function;Gene Transduction Agent;Genetic Transcription;Hand;Heart Block;Hip region structure;Human;improved;indexing;Individual;Inherited;interstitial cell;Laboratories;Link;Measurement;Messenger RNA;Methods;Monitor;motility disorder;mouse model;Movement;Mus;Muscle;Muscle Fibers;Muscle function;Muscle Weakness;Myotonia;Myotonic Dystrophy;Myotonic dystrophy type 1;Needle biopsy procedure;New Agents;novel;novel therapeutics;oligonucleotide therapeutics;Oligonucleotides;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;pharmacodynamic biomarker;pharmacologic;Phase;Physiological;population stratification;preclinical study;premature;preservation;Procedures;Process;Program Development;programs;Property;prospective;Protein Isoforms;Proteins;Regimen;Reporting;response;RNA;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Severity of illness;Shoulder;Skeletal Muscle;small molecule;Speed;Symptoms;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Trials;tibialis anterior muscle;Time;Toxic effect;Transcript;transcriptome sequencing;treatment response;trial design;Validation;wasting

PROJECT_TITLE: Pharmacodynamic Biomarker of Myotonic Dystrophy

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: NORTHSIDE HOSPITAL ATLANTA

ORG_STATE: GA

PHR: Project Narrative GA NCORP Community Site addresses two important challenges in US public health: expanding cancer research to a broader population and including underserved populations in cancer research. Advances in clinical care and scientific discovery are not currently equally available to all races and ethnic groups. GA NCORP will continue to analyze data to identify areas for potential improvement, identify proven best practices, and utilize the expertise of research network affiliates and disparities experts to develop and enhance efforts to achieve equitable access to clinical trials.

PI_NAMEs: CANTUARIA, GUILHERME  (contact);HENRY, LEONARD R.

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Address;Adherence;Adolescent;Adolescent and Young Adult;Advocate;Aftercare;anti-cancer research;Area;base;biobank;cancer care;cancer clinical trial;Cancer Control;cancer health disparity;Cancer Hospital;Cancer Patient;care delivery;Caring;clinical care;Clinical Research;clinical trial enrollment;Clinical Trials;clinically significant;Collaborations;Collection;Communities;Community Clinical Oncology Program;community involvement;Contracts;control trial;Data;Development;Diagnosis;Disparity;Education;Elderly;Eligibility Determination;Enrollment;Equity;ethnic minority;Ethnic Population;evidence base;Evidence based practice;gender minority;Genetic Counseling;Goals;Guidelines;health care service organization;human subject;Image;imaging study;Improve Access;improved;Individual;Infrastructure;insight;Institution;Leadership;Maintenance;Malignant neoplasm of ovary;Malignant Neoplasms;medical specialist;Monitor;National Cancer Institute;National Comprehensive Cancer Network;Newly Diagnosed;Oncologist;Oncology;Participant;participant enrollment;Patient Outcomes Assessments;patient population;Patient-Focused Outcomes;Patients;Population;Prevention;Prevention trial;programs;protocol development;Protocols documentation;Public Health;Quality of Care;Quality of life;racial minority;racial population;Recording of previous events;Research;Research Design;Research Personnel;research study;Resources;Risk;rural dwellers;screening;Sexual and Gender Minorities;Side;simulation;Site;Structure;Study Subject;symptom management;treatment trial;Underrepresented Populations;Underserved Population;young adult

PROJECT_TITLE: Georgia NCI Community Oncology Research Program (GA NCORP)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Clinical Research;Diabetes;Digestive Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Relevance to Public Health Statement Acute pancreatitis is increasing in incidence and can lead to diabetes in some patients. Diabetes is a morbid disease. We plan to study both established and novel risk factors for developing diabetes in patients with acute pancreatitis.

PI_NAMEs: KALYANI, RITA R;SINGH, VIKESH  (contact);SUN, ZHAOLI

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Acute;Acute Necrotizing Pancreatitis;acute pancreatitis;Address;Antibodies;Autoantibodies;Autoantigens;Autoimmune Diabetes;Autoimmune Diseases;Autoimmune Responses;Autologous Transplantation;Beta Cell;Biochemical;Biological Markers;biomarker identification;Biopsy Specimen;Clinical;clinical center;Clinical Data;clinical risk;Clinical/Radiologic;Collection;Communicable Diseases;Development;Diabetes Mellitus;Disease;Disease Progression;experience;fabrication;Fatty acid glycerol esters;follow-up;Functional disorder;Future;Glucagon;Goals;Hospitals;Human;Hypoglycemia;Image;impaired glucose tolerance;Impairment;improved;Incidence;Individual;Inflammatory;Institution;Insulin;Insulin-Dependent Diabetes Mellitus;islet;Life;Machine Learning;machine learning model;machine learning prediction;macrovascular disease;Malignant Neoplasms;Mediating;Meta-Analysis;Methodology;model development;Morbidity - disease rate;mortality;novel;nutrient absorption;Organ;Organ failure;Pancreas;Pancreatic Diseases;Pathology;Patients;Prediabetes syndrome;predictive modeling;Process;Proteome;Proteomics;Public Health;radiological imaging;Radiology Specialty;radiomics;Recording of previous events;Recovery;Recurrence;Research;Research Design;Research Personnel;Resolution;Resources;Risk Factors;Role;Serology;Serum;subcutaneous;systematic review;Systemic Inflammatory Response Syndrome;Techniques;Technology;Texture;Time;Total Pancreatectomy;Visceral;X-Ray Computed Tomography

PROJECT_TITLE: Clinical, Radiologic and Biochemical Factors Related to Diabetes Development after Acute Pancreatitis


ADMINISTERING_IC: AI

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Food Allergies;Genetics;Infectious Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project narrative Dysregulated mucosal immune responses to dietary or microbial antigens can cause severe diseases. The main goal of this research program is to study the nature of immune cells communication that dictates tolerance or inflammation to food and microbes. This work will provide both a new perspective for the understanding of intestinal disorders and a foundation for the development of new therapies targeting specific cells, genes, and pathways.

PI_NAMEs: CAMPOS CANESSO, MARIA CECILIA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Advisory Committees;Allergic;Anti-Inflammatory Agents;Antigen-Presenting Cells;Antigens;Automobile Driving;Award;career development;CD4 Positive T Lymphocytes;Cell Communication;Cells;Charge;Colitis;Color;commensal bacteria;Communication;confocal imaging;Dendritic Cells;Development;Development Plans;dietary;Dietary Proteins;Digestive System Disorders;Disease;draining lymph node;effector T cell;enteric infection;enteric pathogen;Equilibrium;Etiology;Face;Flow Cytometry;Food;Food Hypersensitivity;Foundations;Functional Imaging;functional outcomes;Gene Modified;Gene Targeting;Generations;Genes;Genetic;Goals;gut inflammation;gut microbiota;Health;Homeostasis;host-microbe interactions;Hypersensitivity;ileum;Image;imaging genetics;Immune;Immune response;Immune system;Immunity;Immunology;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;insight;intestinal barrier;Intestinal Diseases;intestinal homeostasis;Intestines;Label;Location;Mentors;Mentorship;Microbe;microbiome;microbiota;microorganism antigen;migration;Molecular;mouse genetics;Mucosal Immune Responses;Mucous Membrane;Mus;Nature;new technology;new therapeutic target;novel;novel therapeutics;Nutrient;oral tolerance;Outcome;pathogen;Pathologic;Pathway interactions;Phase;Physiological;Population;Predisposition;preservation;prevent;Process;programs;Property;Public Health;rational design;Reaction;Regulatory T-Lymphocyte;Research;Research Personnel;Research Proposals;Resources;response;Role;single-cell RNA sequencing;Stimulus;System;T cell differentiation;T-Cell Activation;T-Lymphocyte;Technology;Testing;tool;Training;transcriptomics;Universities;Work

PROJECT_TITLE: Cell-cell interactions driving gut inflammation and tolerance

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NORTHRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

ORG_STATE: CA

PHR: PROJECT NARRATIVE The stomach is an important barricade that kills many bacteria before they can cause illness, in part by using its acidity to inactivate bacterial proteins. Some bacteria contain small chaperone proteins called HdeA and HdeB that help protect other proteins from becoming permanently inactivated and therefore help bacteria survive and cause infection. We are interested in studying, in-depth, how HdeA and HdeB work as a team to protect other proteins, and also how targeted modifications of each chaperone affect their structure and function; the insight we gain may aid others in the development of vaccines or therapeutics that combat dysentery.

PI_NAMEs: CROWHURST, KARIN A (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: acid stress;Acidity;Acids;Affect;Award;Bacteria;Bacterial Proteins;Binding;Binding Sites;Biological Models;biological systems;biophysical techniques;Brucella abortus;Cells;Cessation of life;Circular Dichroism;Client;combat;Data;diarrheal disease;dimer;Disease;Dissociation;disulfide bond;Dysentery;enteric infection;Environment;Escherichia coli;experimental study;Exposure to;flexibility;Funding;Goals;Health;Human;improved;In Vitro;Individual;Infection;innovation;insight;interest;Intestines;Investigation;Isotope Labeling;Link;Measures;Modeling;Molecular Chaperones;Molecular Conformation;molecular dynamics;Molecular Mechanisms of Action;Monitor;monomer;mutant;Mutation;NMR Spectroscopy;Occupations;pathogenic bacteria;periplasm;Periplasmic Proteins;Persons;Physiological;Play;Positioning Attribute;Process;Property;protein aggregation;Protein Engineering;protein folding;protein structure;Proteins;Publishing;Recovery;Research Personnel;Resolution;Role;Series;Shigella flexneri;Site;Site-Directed Mutagenesis;stem;Stomach;Structure;synergism;targeted treatment;Techniques;Testing;Therapeutic;Time;Titrations;Travel;Tryptophan;Vaccine Design;vaccine development;Visualization;Work

PROJECT_TITLE: Synergy between acid stress chaperones HdeA and HdeB with clients and their key sites of activity


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Recommendations for addressing the high burden of insufficient sleep among adolescents largely focus on individual-level factors (e.g. sleep hygiene), but the contribution of adolescents' larger environmental context to sleep health has been understudied. The proposed study will expand traditional approaches to assessing environmental effects on health by using advanced, spatiotemporal exposure assessment methods to understand how adolescents' home and neighborhood environments adolescents influence their sleep. This work will provide foundational knowledge regarding adolescents' environmental risks that will lead to an improved understanding of the determinants of adolescent sleep and development of an approach that can be applied across a wide range of modifiable health behaviors to inform preventive interventions and health policies aimed at improving cardiovascular health across the lifespan.

PI_NAMEs: MAYNE, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: actigraphy;Address;Adolescent;adolescent health;Adult;aged;Area;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cellular Phone;Characteristics;Child;Child Health;Childhood;Clinical;cohesion;cohort;Crime;Data;Data Analyses;Data Collection;Development;Diabetes Mellitus;Disease;Ecological momentary assessment;Enrollment;Environment;Environmental Exposure;Environmental Impact;Environmental Risk Factor;epidemiology study;evidence base;Exposure to;Family;Foundations;Funding;Future;Geographic Information Systems;Goals;Green space;Health;Health behavior;Health behavior and outcomes;Health Policy;High School Student;Home;Hour;Household;Housing;Hypertension;improved;Individual;Individual Adjustment;innovation;Intervention;K-Series Research Career Programs;Knowledge;life span;Light;Longitudinal Studies;Measures;Mentorship;Methodology;Methods;mHealth;Modeling;Neighborhoods;Noise;novel;obesity risk;Outcome;Patient Self-Report;Pediatric Hospitals;Pennsylvania;person centered;Philadelphia;poor sleep;Positioning Attribute;preventive intervention;Primary Care;programs;prospective;Public Health;public health intervention;Race;Recommendation;Research;Research Personnel;research study;Resolution;Risk;Schools;Science;skills;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep health;sleep pattern;sleep quality;social;Socioeconomic Status;socioeconomics;spatiotemporal;stress management;stressor;Surveys;Testing;Text Messaging;Time;Training;trend;Universities;urban area;Variant;Work;Youth

PROJECT_TITLE: Integrating GPS, GIS, and Ecological Momentary Assessment to Determine the Effect of Home and Neighborhood Context on Adolescent Sleep

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Digestive Diseases;Liver Disease;Nutrition

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Meal timing and frequency impact the glycemic responses of both diabetic and nondiabetic individuals, and we have shown that the insulinemic response to the first meal is the key determinant of the metabolic response to the second meal. The proposed studies will address questions relevant to this, including whether the direct effect of morning hyperinsulinemia on the liver is the key factor impacting the second meal response and, if so, whether insulin delivery into the peripheral circulation (the route of delivery for the majority of those with insulin-treated diabetes) can produce a similar response. Moreover, we will identify the second meal factor (elevated glucose or insulin or the signal generated by intraportal entry of glucose) most clearly impacted by the first meal, which can also provide valuable information for designing new treatments for those with diabetes and pre-diabetes.

PI_NAMEs: CHERRINGTON, ALAN D (contact);EDGERTON, DALE S

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Accounting;Address;Adrenal Glands;Adult;Affect;Animal Model;Blood Glucose;blood glucose regulation;Brain;Buffers;canine model;Canis familiaris;Caring;Catheterization;Central Nervous System;Chronic;Circulation;Clinical;Closure by clamp;Complex;Conscious;Control Groups;design;Development;Diabetes Mellitus;diabetic;Drug Kinetics;Duodenum;Eating;Elements;Epinephrine;experimental study;Fasting;Fatty acid glycerol esters;feeding;Fiber;Frequencies;Generations;Glucagon;Glucose;glucose disposal;glucose production;glucose uptake;glycemic control;Glycogen;Goals;Hepatic;Hepatic artery;hepatic vein;Hormonal;Hormone secretion;Human;Hyperglycemia;Hyperinsulinism;Hypoglycemia;Iatrogenesis;impaired glucose tolerance;improved;incretin hormone;Individual;Infusion procedures;Ingestion;innovation;Insulin;Insulin Resistance;insulin secretion;Insulin-Dependent Diabetes Mellitus;Investigation;Islets of Langerhans;Knowledge;Leg;Limb structure;Liver;Liver Glycogen;Measures;Metabolic;Modeling;Muscle;neural;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Nutrient;Oral;Oral Ingestion;Organ;Pattern;Peripheral;Persons;Physiological;Play;Population;Portal vein structure;Prediabetes syndrome;Process;Regulation;response;Risk;Role;Route;Saline;Sampling;Signal Transduction;Site;Skeletal Muscle;Spinal;Techniques;Teenagers;Tissues;transmission process;treatment response;Vagus nerve structure;Veins;Withdrawal;Work

PROJECT_TITLE: Morning Meal-Associated Priming of the Liver

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: Narrative This project aims to develop and apply advanced and scalable and interpretable statistical and machine learning methods and tools to empower the integrative analysis of large-scale biobanks, germline and somatic whole genome/exome sequencing (WGS/WES) cancer studies and experimental single cell based cell-specific omic data. These methods and tools will accelerate the progress in advancing from cancer gene mapping to mechanisms to cancer precision prevention and medicine. We will develop open access high-performance cluster and cloud based software of these methods and data resources and make them available to the cancer research community.

PI_NAMEs: LIN, XIHONG  (contact)

PROGRAM_OFFICER_NAME: CHEN, HUANN-SHENG

PROJECT_TERMS: Acceleration;Advanced Malignant Neoplasm;anti-cancer research;ATAC-seq;Award;biobank;Biological Markers;Biology;Breast Cancer Genetics;cancer epidemiology;cancer genetics;cancer health disparity;cancer prevention;Cancer Prognosis;cancer subtypes;causal variant;Cells;Characteristics;Chromosome Mapping;Clinical;Clinical Data;Clinical Research;cloud based;Communities;Computer software;Data;Data Commons;data resource;Data Science;empowerment;epidemiologic data;Ethnic Origin;Etiology;Event;exome sequencing;Genes;Genetic;genetic analysis;genetic epidemiology;Genetic Medicine;Genetic Research;genetic variant;Genome;genome sequencing;genomic data;Germ Lines;Goals;Hematopoiesis;Heritability;Immunotherapy;improved;Joints;Length;Leukocytes;machine learning method;Malignant neoplasm of lung;Malignant Neoplasms;Mediation;Medicine;Mendelian randomization;Methods;mitochondrial dysfunction;multi-ethnic;multiple omics;non-genetic;Pathway interactions;Performance;phenome;Phenotype;phenotypic data;Population;population based;Population Study;precision cancer prevention;precision medicine;Prevention strategy;profiles in patients;rare variant;Reduce health disparities;Research Personnel;response;Risk;RNA;Silicon;statistical and machine learning;Statistical Methods;telomere;tool;treatment strategy;tumor;United States National Institutes of Health;Variant;whole genome

PROJECT_TITLE: Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer Research


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative: The long-term goal of this study is to determine how vagus nerve stimulation (VNS) regulates basal dopamine transmission and methamphetamine regulation of dopamine neurons. Our preliminary data support the idea that VNS can decrease methamphetamine- mediated stimulation of dopamine transmission. Our proposed mechanism is that VNS depolarizes dopamine neurons, internalizes dopamine transporter, and increases basal dopamine levels to bring about methamphetamine desensitization.

PI_NAMEs: KHOSHBOUEI, HABIBEH  (contact)

PROJECT_TERMS: Action Potentials;Acute;Affect;Afferent Neurons;Attenuated;Behavior;Behavioral;behavioral response;Biochemical;Biological Assay;biophysical analysis;Biotinylation;Brain;Cells;cocaine seeking;combinatorial;conditioned place preference;Corpus striatum structure;Data;desensitization;Dopamine;dopamine transporter;dopaminergic neuron;Exhibits;extracellular;FOS gene;Future;Goals;Grant;Halorhodopsins;Histologic;Image;Immunohistochemistry;in vivo;Induced Neurons;Injections;Light;Literature;LoxP-flanked allele;Measurement;Mediating;Membrane;Methamphetamine;methamphetamine abuse;Methamphetamine dependence;methamphetamine exposure;Microinjections;Midbrain structure;Molecular Conformation;mouse model;Mus;N-Methylaspartate;Neurons;neurophysiology;neurotransmitter release;Nodose Ganglion;NR1 gene;Optics;optogenetics;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Phosphorylation;Preparation;prevent;Property;psychostimulant;Public Health;Regulation;Reporting;response;Rewards;Slice;Synapses;Testing;transcriptomics;Translating;transmission process;Upper digestive tract structure;uptake;vagus nerve stimulation;Vagus nerve structure;Viral

PROJECT_TITLE: Vagus nerve stimulation increases basal dopamine levels in the brain to decrease methamphetamine-mediated responses

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Services;Hypertension;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Hypertension remains a major contributor to morbidity and mortality in the United States, and a fifth of affected individuals have a form of hypertension that appears resistant to usual approaches. The ability to reliably distinguish true resistant hypertension from pseudo-resistant hypertension (due to under-prescribing, medication non-adherence, or white coat effect) is essential for minimizing diagnostic and therapeutic errors. We will use electronic health record based analytics and tools to develop a clinically feasible and pragmatic approach to improving the quality and value of care for patients with resistant hypertension.

PI_NAMEs: EBINGER, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;adjudication;Adoption;Affect;Algorithms;Ambulatory Blood Pressure Monitoring;American;Anti-Hypertensive Agents;Automobile Driving;Bioinformatics;Biometry;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;Cardiology;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;care delivery;career;Caring;Clinical;clinical decision support;Clinical Informatics;clinical practice;clinical research site;Complex;computerized;computerized data processing;cost;Data;Data Analytics;Data Set;design;Detection;Development;Diagnosis;Diagnostic;Disease;Disease Management;Dose;Electronic Health Record;electronic health record system;Environment;Evaluation;Event;evidence base;experience;Explosion;falls;Focus Groups;Future;Guidelines;health data;health information technology;Health Services Research;Health Status;Health system;Healthcare Systems;Heart;Home Blood Pressure Monitoring;Hypertension;hypertension treatment;implementation science;improved;Individual;individualized medicine;Informatics;Infrastructure;innovation;insight;Institution;Intervention;Interview;Intuition;K-Series Research Career Programs;Manuals;medication compliance;medication nonadherence;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Morbidity - disease rate;mortality;Myocardial Infarction;Notification;Outcome;Outcomes Research;Outpatients;Patient Care;Patients;Pattern;Patterns of Care;Performance;Pharmaceutical Preparations;pilot test;population health;practice setting;pragmatic intervention;Prevalence;Preventive;Primary Care;Production;programs;prospective;prototype;Provider;Quality of Care;Research;Research Personnel;Research Project Grants;Research Proposals;Resistance;Resistant Hypertension;Risk;scientific computing;skills;Specialist;Stroke;Structure;support tools;Surveys;Syncope;System;Technology;Testing;Therapeutic;tool;Training;Training Programs;United States;usability;Visit;Work

PROJECT_TITLE: Implementation Science to Improve Cardiovascular Health: Leveraging EHR Systems to Advance Care of Resistant Hypertension

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Depression;Mental Health;Neurodegenerative;Palliative Care;Social Determinants of Health

ORG_CITY: Columbus

ORG_DEPT: PSYCHIATRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This study addresses two key questions: Does the chronic stress of dementia spousal caregiving accelerate molecular aging? Can caregiving-related distress propel molecular aging and shorten health span (the length of time that a person is healthy—not just alive)? This project will provide insight into the pathways through which caregiving can produce substantial health risks, and it will also explore possible paths to caregiving’s potential health benefits.

PI_NAMEs: CHRISTIAN, LISA MICHELLE (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Acceleration;Address;Age;age acceleration;age related;Aging;aging biomarker;Bacterial Translocation;Behavior;Behavioral;Biological Aging;Biological Markers;care recipients;Caregiver Burden;caregiver stress;Caregivers;caregiving;Caring;CD8-Positive T-Lymphocytes;CDKN2A gene;Chronic;Chronic stress;Chronology;Clinic;clinically significant;Cytomegalovirus;Data;Dementia;Dementia caregivers;dementia caregiving;depressive symptoms;design;Dimensions;Disease;Distress;Eligibility Determination;Endotoxins;Epigenetic age;extend lifespan;Family Practice;follow-up;frailty;frontier;Gender;Health;Health Benefit;healthspan;Home;immune function;Immune system;Immunologics;Impairment;Individual;Inflammaging;Inflammation;innovation;insight;Intake;Intestinal permeability;Leaky Gut;Length;life span;Longevity;Memory;Memory Disorders;men;Mental Depression;Meta-Analysis;Methodology;Molecular;Moods;Morbidity - disease rate;mortality;Nature;novel;Ohio;Outcome;Pathway interactions;Persons;Process;prospective;recruit;Research;Risk;Risk Behaviors;Sampling;secondary analysis;seropositive;social relationships;sociodemographics;Source;Spouse Caregiver;Spouses;Stress;stressor;Support Groups;telomere;Telomere Shortening;Testing;Time;Visit;Woman

PROJECT_TITLE: Spousal Dementia Caregivers:  Risk for Accelerated Aging

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;Neurosciences;Rare Diseases;Scleroderma

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Increasing evidence demonstrates that systemic sclerosis-related constipation (SSc-constipation) is a common and often severe problem, associated with significant morbidity and mortality. However, several subgroups of SSc-constipation exist [i.e. slow colonic transit, rectal hyposensitivity, or anorectal dyssynergy (i.e. pelvic floor dysfunction)], and are hypothesized to have different mechanisms which may involve abnormal autonomic and pelvic reflexes. In this proposal we will interrogate the relationship between each SSc-constipation subgroup and [1] physiological responses to transcutaneous electrical acustimulation (an intervention that is known to alter autonomic and pelvic reflexes); [2] measures of autonomic dysfunction; and [3] inflammation to better understand disease mechanism and predict response to therapy.

PI_NAMEs: CHEN, JIANDE ;MCMAHAN, ZSUZSANNA HORTOBAGYI (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Acceleration;Acustimulation;Aftercare;Anus;Automobile Driving;Autonomic Dysfunction;Autonomic nervous system;Central Nervous System;Clinical;clinically relevant;Colon;Colorectal;Communication;Constipation;cytokine;Data;Defecation;Defect;design;Development;Disease;Enteric Nervous System;Equilibrium;Esthesia;Exclusion;experience;Functional disorder;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal Physiology;gastrointestinal symptom;Growth;heart rate variability;Home;improved;Inflammation;Inflammatory;inflammatory modulation;Interleukin-6;Intervention;Intestines;Knee;Life;Manometry;Measurement;Measures;Mediating;Megacolon;Morbidity - disease rate;mortality;Motility;Muscle relaxation phase;Nervous System Physiology;Neuronal Dysfunction;neuroregulation;novel therapeutics;Obstruction;Outcome;Pathway interactions;Patient Outcomes Assessments;Patients;Pelvic floor dysfunction;Pelvis;peroneal nerve;Physiological;Physiology;Pilot Projects;Play;Prediction of Response to Therapy;Predictive Value;Prevalence;primary outcome;Production;Quality of life;recruit;Rectum;Recurrence;Reflex action;Relaxation;Reporting;Resolution;response;Rheumatism;Role;sciatic nerve;secondary outcome;Sensory;sensory system;Severities;Site;Small Intestines;Statistical Data Interpretation;Structure of tibial nerve;Subconscious;Subgroup;Surveys;symptomatic improvement;Symptoms;systemic inflammatory response;Systemic Scleroderma;Testing;Total Parenteral Nutrition;treatment response;wearable device;wireless;Work

PROJECT_TITLE: Interrogating the pathophysiological mechanisms of constipation in patients with systemic sclerosis


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cerebral Palsy;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: DANVILLE

ORG_NAME: GEISINGER CLINIC

PHR: PROJECT NARRATIVE Cerebral palsy (CP) is a common (prevalence 1 in 500) developmental brain disorder affecting early motor development, and although birth asphyxia was long considered the most frequent cause, it actually accounts for less than 10% of CP cases. Recent evidence, which requires further investigation, indicates that a large proportion of CP is likely genomic in origin. We propose a novel, cost-effective strategy to leverage genomic and clinical data from Geisinger’s healthcare-based population and referrals from a major clinical genetics laboratory to enroll individuals with CP and identify the critical regions of the genome and individual genes responsible for CP.

PI_NAMEs: MYERS, SCOTT  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Adult;Affect;Architecture;Asphyxia Neonatorum;autism spectrum disorder;bioinformatics tool;Biological;brain abnormalities;Brain Diseases;Candidate Disease Gene;candidate identification;Cerebral Palsy;Childhood;Clinical;clinical care;Clinical Data;cohort;Cohort Analysis;Collaborations;Common Data Element;comorbidity;Copy Number Polymorphism;Correlation Studies;cost effective;Data;Data Set;Databases;Development;Disease;Electronic Health Record;Enrollment;Etiology;Evaluation;exome sequencing;Fostering;Frequencies;Gene Family;Generations;Genes;genetic variant;Genome;genome wide association study;genomic data;Genomics;Genotype;Guidelines;Healthcare;Heritability;Human;Impairment;Individual;Intellectual functioning disability;Investigation;Knowledge;Laboratories;Link;Medical;Medical Genetics;Molecular;Motor;National Institute of Neurological Disorders and Stroke;neuroimaging;novel;novel strategies;Ontology;Outcome Study;Participant;Pathogenicity;Pathway interactions;Patients;Pediatric cohort;Phenotype;phenotypic data;population based;Prevalence;Publishing;rare variant;recruit;Research;Risk Factors;Role;Site;SNP genotyping;Source;Standardization;Subgroup;success;targeted treatment;Testing;transmission process;Variant

PROJECT_TITLE: Characterizing the spectrum of genomic and phenotypic variation in cerebral palsy

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative/Relevance to Public Health Older adults disproportionately experience high rates of “low-value care” – tests and procedures with no benefit that often harm patients. This proposal aims to advance academic-health system partnerships in real-world settings to reduce wasteful spending, ensure that patients receive appropriate and high-quality care, and reduce racial and ethnic disparities in the receipt of high-value care. The proposed infrastructure will also facilitate mentoring and support the next generation of patient-oriented researchers in aging.

PI_NAMEs: SARKISIAN, CATHERINE A (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Academic support;Address;Affect;Aging;Area;Award;behavior change;Behavioral;behavioral economics;California;Cardiac;career;Career Mobility;Caring;Clinical;clinical decision-making;Clinical Trials;Collaborations;community academic partnership;community engaged research;cost;COVID-19;Data;data management;Decision Making;design;Electronic Health Record;Ensure;ethnic disparity;ethnic diversity;experience;Faculty;Funding;Grant;Health;health disparity;Health Services;Health system;Healthcare Systems;high risk population;Home;implementation intervention;implementation science;improved;Individual;Infrastructure;Inpatients;Intention;Interdisciplinary Study;Intervention;Intervention Trial;Investigation;Leadership;Learning;Measures;Medical center;medical schools;Mentors;Mentorship;Minority;Mission;next generation;older adult;operation;Outcome;patient oriented;patient oriented research;Patients;Persons;Pharmaceutical Preparations;population health;Postdoctoral Fellow;pragmatic trial;prevent;Procedures;Productivity;Public Health;Publications;Quality of Care;Quality of life;racial disparity;randomized, clinical trials;Randomized, Controlled Trials;Research;Research Personnel;Research Support;Resources;Scientific Advances and Accomplishments;Scientist;Series;Services;skills;Testing;Time;Universities;Work

PROJECT_TITLE: Midcareer Award in Patient-Oriented Aging Research

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative  Clinical trial of the photovoltaic substitute for the lost photoreceptors in AMD patients confirmed the safety of such implants (PRIMA) and spatial resolution closely matching the 100µm pixel size. This proposal describes three complimentary approaches to advance this technology towards 20µm pixels in order to enable visual acuity exceeding 20/100, which should allow highly functional restoration of sight. All three approaches, including the pillar electrodes and optical current steering, demonstrated very encouraging preliminary results, and will now be developed to the full extent.

PI_NAMEs: PALANKER, DANIEL V (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Algorithms;Anatomy;Anodes;Blinded;Blindness;Cathodes;Cells;Clinical;Clinical Trials;Computer Models;Contrast Sensitivity;Darkness;design;electric field;Electric Stimulation;Electrodes;Electrolytes;Electronics;functional restoration;ganglion cell;geographic atrophy;Geometry;Image;Implant;in vivo;Lateral;Letters;Light;Lighting;Maps;Measures;Mediating;migration;neuronal survival;Neurons;Nonexudative age-related macular degeneration;Ocular Prosthesis;Optics;Patients;Pattern;Penetration;Peripheral;Photoreceptors;Physiologic pulse;Prosthesis;Rattus;research clinical testing;Resolution;Retina;Retinal Degeneration;retinal neuron;retinal stimulation;Safety;Sampling;Shapes;Shunt Device;sight restoration;spatiotemporal;Technology;Testing;Tissues;Vision;Visual Acuity;visual information

PROJECT_TITLE: Electronic photoreceptors for restoration of sight in retinal degeneration

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Lupus;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease with a female to male ratio of 9:1. We recently identified an evolutionary conserved sex-biased transcriptional regulator VGLL3, which leads to development of an IL-7 dependent SLE-like disease when overexpressed in skin. In this application we will elucidate the mechanism of this novel VGLL3-IL7-autoimmune pathway in SLE pathogenesis.

PI_NAMEs: GUDJONSSON, JOHANN ELI (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Address;Affect;American;anti-dsDNA antibodies;Antibodies;Antigen-Antibody Complex;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;autoreactive T cell;autosome;B-Lymphocytes;Basement membrane;Binding;biological age;Cell Nucleus;cell type;Chronic;cofactor;Cre driver;Cutaneous;cytokine;Cytoplasm;Data;Dependence;Deposition;Development;Disease;Disease susceptibility;Disproportionately impacts women;ds-DNA;Epidermis;Family;Female;FOXM1 gene;Future;Genes;Genetic Transcription;Gonadal Steroid Hormones;hormone regulation;Human;human male;IL7 gene;Immune;Immune response;Immune Response Genes;Immunoglobulin G;in silico;In Vitro;in vivo;Inflammatory;Interferon Activation;Interferon Type I;Interferons;Interleukin 7 Receptor;keratin 5;keratinocyte;Kidney;Knock-out;Knockout Mice;Life;Location;LoxP-flanked allele;Lupus;Lymphoid Tissue;male;Mediating;member;men;Modeling;mouse model;Mus;Myeloid Cells;Nephritis;Neurofibromin 2;novel;novel strategies;Nuclear;overexpression;pathogen;Pathogenesis;Pathway interactions;Peripheral;Phenotype;Predisposition;prevent;Process;programmed cell death protein 1;promoter;Protein Isoforms;protein transport;Proteins;Regulation;Regulatory Pathway;response;Response Elements;Role;Sex Bias;Sex Chromosomes;sex determination;Sex Differences;sexual dimorphism;Signal Pathway;Signal Transduction;Skin;SLEB1 gene;SLEB3 gene;SOX7 gene;systemic autoimmune disease;systemic inflammatory response;Systemic Lupus Erythematosus;T-Cell Development;T-Lymphocyte;therapeutic target;Thymus Gland;TLR7 gene;trafficking;transcription factor;Transgenic Mice;Transgenic Organisms;Woman;women's morbidity;Work

PROJECT_TITLE: Role of the gender biased transcription factor VGLL3 in promoting autoimmune responses in SLE


ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE The mammalian cerebral cortex is the center of remarkable cognitive, perceptive, and motor capabilities, the execution of which depends on the correct assembly of circuit connectivity during development. Miswiring of cortical circuitry can contribute to disorders of brain development. In this study, we seek to understand the roles of subplate neurons in orchestrating the formation of cortical circuits, and the potential contribution of subplate neuron dysfunction to neurodevelopmental disorders.

PI_NAMEs: KWAN, KENNETH YU-CHUNG (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Ablation;ARID1A gene;Axon;axon growth;axon guidance;axonal pathfinding;Biological Assay;Biology;Brain Diseases;Candidate Disease Gene;candidate selection;cell type;Cells;Cerebral cortex;Chromatin;Coffin-Siris Syndrome;Cognitive;Corpus Callosum;Data;Defect;Development;developmental disease;differential expression;DNA Binding;Embryo;Extracellular Matrix;follow-up;Functional disorder;functional genomics;Gene Deletion;Gene Expression Regulation;gene function;Gene Silencing;Genes;Genetic;genetic approach;genetic manipulation;Genetic Models;Genetic Transcription;Genomic approach;genomic locus;Genomics;gray matter;Human;in utero;in vivo;innovation;insight;Intellectual functioning disability;Maps;Mediating;Molecular;Molecular Genetics;Motor;Muscle fasciculation;Mutation;nerve stem cell;neural circuit;Neurobiology;Neurodevelopmental Disorder;neuronal circuitry;Neuronal Dysfunction;Neurons;novel;Phenocopy;Phenotype;Play;Positioning Attribute;Reporting;Role;Sensory;single nucleus RNA-sequencing;SOX5 gene;Specificity;Syndrome;Testing;transcription factor;transcriptomics;white matter;Work

PROJECT_TITLE: Subplate-dependent mechanisms of cortical circuit assembly

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The phosphatidylinositol phosphate 5-kinases are responsible for the synthesis of two functionally important phosphatidylinositol bisphosphates, PI(4,5)P2 and PI(3,5)P2. Biochemical and crystallographic experiments are planned in this application to study how these lipid kinases achieve substrate specificity and how pharmacological inhibition of PIKfyve could disrupt SARS-CoV-2 replication within infected cells.

PI_NAMEs: HA, YA  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: 2019-nCoV;analog;Binding;Biochemical;Biological;Biology;Catalytic Domain;CCR;Cell Culture Techniques;Cell Line;Cells;Chemicals;clinical center;clinical investigation;Complex;COVID-19 treatment;crosslink;Crystallization;Crystallography;Development;Disease;drug repurposing;Ebola virus;Elements;Endosomes;Epithelial Cells;experimental study;Family;Future;Genetic;Goals;Head;Human;Hydroxyl Radical;In Vitro;Infection;inhibitor;Inositol;Integration Host Factors;interest;Knock-in;Knock-out;Knowledge;Lead;Life Cycle Stages;Lipids;Lung;Marburgvirus;member;Membrane;Molecular Conformation;mutant;Pattern;Pharmaceutical Chemistry;pharmacologic;Pharmacology Study;Phase II Clinical Trials;phosphatidylinositol 5-phosphate;Phosphatidylinositol Phosphates;Phosphatidylinositols;Phosphorylation;Phosphotransferases;Positioning Attribute;programs;Refractory;Research;Resolution;Role;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;Sequence Homology;small molecule inhibitor;Specificity;Structure;Substrate Specificity;Testing;tool;trafficking;Viral;Viral Physiology;Work

PROJECT_TITLE: The biochemical mechanism and pharmacological inhibition of phosphatidylinositol phosphate kinases

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE

PHR: Public Health Relevance Amblyopia (`lazy eye') is the leading cause of monocular vision loss in children worldwide and affects 3-5% of the population. With current patching treatment, the success rate is about 60-80% with 20-25% recurrence following the treatment, leaving about one third of affected children with amblyopia that persists into adulthood. Visual suppression plays a critical role in developing amblyopia, failure of treatment, and regress following the treatment. This project aims to comprehensively investigate the neural basis of how and where amblyopic suppression occurs in the brain. Understanding the neural mechanisms underlying visual suppression can significantly help prevent and treat amblyopia.

PI_NAMEs: HOU, CHUAN  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Adult;Affect;Agreement;Amblyopia;Anisometropia;Area;Attention;attentional bias;attentional modulation;behavior measurement;Behavioral;Binocular rivalry;Blindness;Brain;Characteristics;Child;Chronic;Correlation Studies;Coupled;Cues;Data;early childhood;Electroencephalography;extrastriate visual cortex;Eye;Frequencies;Functional Magnetic Resonance Imaging;Funding;Goals;Image;improved;induced pluripotent stem cell;Knowledge;Lazy Eyes;Measures;monocular;Monocular Vision;Motion;neural;neural correlate;neuromechanism;Ocular Dominance;Optics;Pattern;Perception;Performance;Physiological;Play;Population;prevent;Psychophysics;public health relevance;Recurrence;Refractive Errors;Resources;response;Role;Scotoma;selective attention;Signal Transduction;Source;Stimulus;Strabismus;success;Testing;Therapeutic;Training;Treatment Failure;Vision;Visual;Visual attention;Visual Cortex;Visual Perception;visual processing;Visual Psychophysics;Work

PROJECT_TITLE: Interocular Suppression and Selective Attention in Amblyopia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-U(02)M]


NIH_SPENDING_CATS: Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Kidney Disease;Women's Health Research

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Hypertension is a leading modifiable risk factor for cardiovascular and renal disease that remains suboptimally controlled in at least one third of treated patients, putting them at an increased risk of premature death. Biological sex has become increasingly recognized as a pivotal factor affecting the development and pathophysiological outcomes of hypertension, however limited understanding of the sex-specific mechanisms regulating blood pressure poses a critical barrier to the optimization of antihypertensive therapies. The current proposal addresses this knowledge gap and improves our understanding of blood pressure control mechanisms in both sexes.

PI_NAMEs: MAMENKO, MYKOLA  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: absorption;Accounting;Address;Adrenalectomy;Adult;Affect;Albuminuria;Aldosterone;Amiloride;Angiotensin II;Animal Model;Animals;antagonist;Anti-Hypertensive Agents;Area;artery infusion;Attenuated;Automobile Driving;biological sex;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;blood pressure regulation;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chronic;Clinical;clinically relevant;cohort;combat;Data;decubitus ulcer;Development;Disease;Distal;Dose;epithelial Na+ channel;Equilibrium;Excretory function;Exhibits;experimental study;Female;female sex hormone;Functional disorder;Genomics;Gonadal Steroid Hormones;Human;Hypersensitivity;Hypertension;hypertensive;improved;Inflammation;Infusion procedures;inhibitor;Injury to Kidney;Intervention;Investigation;Kidney;Kidney Diseases;Knowledge;Link;male;Measures;Mediating;men;Microscopy;Mineralocorticoid Receptor;modifiable risk;Molecular;Mus;Natriuretic Peptides;Nephrons;non-genomic;novel;Outcome;Pathogenicity;Pathology;Pathway interactions;Patient Noncompliance;Patients;Population;pre-clinical;premature;Production;Public Health;Quantitative Reverse Transcriptase PCR;Randomized;Rattus;receptor expression;Receptor Inhibition;Regulation;renal artery;renal damage;renal epithelium;response;reuptake;Risk;Rodent;Safety;salt sensitive;sex;Sex Differences;sex disparity;Signal Transduction;Sodium;Testing;Therapeutic;Titrations;Treatment Efficacy;treatment strategy;treatment stratification;Western Blotting;Woman

PROJECT_TITLE: Sex disparities in aldosterone-dependent renal Na+ transport and blood pressure control

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE Hand tendon injures are very common and need surgical repair, however, the clinical results after repair have not reached patients’ satisfaction because of adhesion and scar formation that glue the injured tendon to the neighboring tissues and harms the hand function. In this study, we will use our newly developed turkey animal model to study tendon healing mechanism and some new treatments using biological agents to improve tendon healing and prevent scar formation.

PI_NAMEs: ZHAO, CHUNFENG  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Address;Adhesions;Affect;Age;Anatomy;Animal Model;Antibodies;Area;Autologous;Basic Science;Biological;Biological Products;Canis familiaris;Carbodiimides;cDNA Library;cell growth;cell type;Cells;Chickens;Chondrocytes;Cicatrix;Client satisfaction;Clinic;Clinical;clinical application;clinical practice;clinical translation;Clinical Trials;clinically relevant;crosslink;Data;Derivation procedure;Development;digital;disability;disability impact;Domestic Fowls;Economic Burden;economic impact;Effectiveness;Elements;exosome;Fibrocartilages;Flexor;foot;functional improvement;functional outcomes;functional restoration;Future;Gelatin;Genetic Markers;genome sequencing;Glues;Good Manufacturing Process;Hand;Hand functions;healing;Human;improved;Injury;Intervention;Intrinsic factor;Knowledge;Lead;Leg;Meleagris gallopavo;mineralization;Modeling;Molecular;molecular marker;Motion;Natural regeneration;Necrosis;novel;Operative Surgical Procedures;Outcome;Patients;Population;Postoperative Period;prevent;Productivity;progenitor;Recovery of Function;regeneration potential;Regenerative Medicine;repair model;repaired;Reporting;Research;response;Rodent;Role;Rupture;Second Look Surgery;severe injury;stem cells;Structure;Surface;Synovial Fluid;Techniques;tendon graft;Tendon Injuries;Tendon structure;Testing;Therapeutic;therapy development;Time;Tissues;tool;Vascular blood supply;Work

PROJECT_TITLE: Flexor tendon intrinsic healing and intervention strategy development

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Substance Misuse

PHR: Project Narrative Many Hispanics who have an alcohol use disorder face much greater difficulties getting treatment than non- Hispanic Whites. This disparity exists partially because there are not enough Spanish-speaking treatment providers who can deliver culturally adapted treatments. This research will develop a brief culturally adapted mobile treatment for alcohol use disorder that Spanish-speaking Hispanics can use through their smartphones on days when they are at high risk for drinking (e.g. weekends, holidays).

PI_NAMEs: BENITEZ, BRYAN  (contact)

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: acceptability and feasibility;Adult;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;Alcoholic Liver Diseases;Alcohols;Award;barrier to care;binge drinking;career;career development;Cellular Phone;Clinical Research;Clinical Trials;Cognitive Therapy;cohort;computerized;Conduct Clinical Trials;Coping Skills;cost effective;cost effectiveness;craving;Data;design;Development;Development Plans;digital delivery;digital technology;Disparity;drinking;Drug usage;E-learning;Educational process of instructing;efficacy evaluation;efficacy research;Evidence based treatment;experience;Face;feasibility testing;Feedback;Focus Groups;Fostering;Future;Goals;Grant;Health Personnel;Health Services Accessibility;high risk;high risk drinking;Hispanic Populations;Holidays;Home;improved;Incidence;Individual;Intervention;Leadership;Life;Linguistics;Measures;Mentors;Methods;minority health;mobile computing;mobile delivery;Modification;mood symptom;Morbidity - disease rate;mortality;Motivation;multilevel analysis;Not Hispanic or Latino;Parameter Estimation;Participant;Patients;Population Heterogeneity;power analysis;Process;programs;prospective;Provider;psychiatric symptom;Publishing;Qualitative Research;Questionnaires;randomized, clinical trials;recruit;reduced substance use;Reporting;Research;satisfaction;secondary outcome;simulation;skills;skills training;Social Processes;socioeconomics;Spanish;stakeholder perspectives;statistics;Substance Use Disorder;sustained attention;Symptoms;System;Testing;Time;Training;Training Programs;Treatment Protocols;United States;United States National Institutes of Health;Universities;usability;user centered design;Writing

PROJECT_TITLE: Targeting High Risk Drinking Days with Mobile Treatment for Spanish-Speaking Patients

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Project Narrative DNA breaks and repairs have been linked to opioid use disorders. To elucidate the mechanism for this, we propose to characterize the changes in DNA damage and repair sites and the associated changes in chromatin accessibility and gene expression in specific types of neurons in mice that self-administered heroin. Our study will therefore provide a novel mechanism for the epigenetic regulation of the transcriptional and behavioral maladaptations underlying opioid addiction, which will fundamentally advance the understanding of the neurobiology of drug addiction.

PI_NAMEs: WANG, ZIJUN  (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Address;Affect;Affinity Chromatography;Animal Model;Autopsy;Behavior;Behavioral;behavioral plasticity;Brain;Cells;Chromatin;chromatin remodeling;Chromatin Structure;Chronic;Clinical Research;Coupled;CRISPR/Cas technology;Data;Disease;DNA;DNA Damage;DNA Repair;Drug Addiction;Epigenetic Process;epigenome;epigenomics;Foundations;Gene Expression;Gene Expression Profile;Genetic;Genetic Transcription;genome editing;Genomics;Goals;Heroin;hippocampal pyramidal neuron;Individual;Induced Neurons;Interneurons;Link;Metabolic;Mus;Neurobiology;Neuronal Plasticity;Neurons;novel;Opiate Addiction;Opioid;opioid abuse;opioid use disorder;Output;Parvalbumins;Play;postmitotic;preclinical study;Predisposition;Prefrontal Cortex;Process;Relapse;repaired;response;reward circuitry;Role;Self Administration;Site;Solid;Tissues;Transcriptional Regulation;transcriptome;translatome

PROJECT_TITLE: The role of DNA breaks and repairs in opioid addiction


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project narrative / Public health relevance statement: We have made major contributions to understanding the molecular pathogenesis of follicular lymphoma (FL). We will now examine the unique dependence of FL cells on their supportive niche. We think this will reveal opportunities for intervention in this incurable cancer. !

PI_NAMEs: WENDEL, HANS-GUIDO  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Affect;B-Cell Lymphomas;B-Lymphocytes;BCL2 gene;Biological Process;Biology;Bispecific Antibodies;Cell Communication;Cell Cycle Regulation;Cells;Cellular Metabolic Process;checkpoint inhibition;chimeric antigen receptor T cells;Chronic Leukemia;CREBBP gene;Data;Dependence;Development;Disease;driver mutation;Elements;Engineering;Epigenetic Process;EZH2 gene;Follicular Lymphoma;Genetic;Genotype;Goals;Human;Immunologic Receptors;Indolent;inhibitor;Intervention;Legal patent;leukemia/lymphoma;Lymphoma;Lymphoma cell;Malignant - descriptor;Malignant Neoplasms;Modeling;Molecular;Molecular Biology;mouse model;mRNA Translation;Mus;Mutation;novel therapeutics;Pathogenesis;PIK3CG gene;public health relevance;Publications;Reporting;Role;Series;Shapes;single-cell RNA sequencing;success;therapy resistant;tool;tumor;Work

PROJECT_TITLE: Towards targeting the lymphoma microenvironment


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: CHICAGO

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project narrative: Numerous biological processes from the immune system to development rely on the ability of biomolecular systems to correctly recognize one molecular signal, such as a viral or signaling protein or a combination of molecules, against a sea of decoys. The goal of the proposed research program is to develop new computational tools and principles that can harness high- throughput experimental data to provide a predictive understanding of how such recognition works, how recognition can go wrong and how it can be engineered on different scales.

PI_NAMEs: MURUGAN, ARVIND  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Algorithms;antibody mimetics;Antibody Specificity;Architecture;Atlases;Binding;Biological Process;biophysical model;Biophysics;Buffers;Cells;Chemistry;circadian pacemaker;Circadian Rhythms;combinatorial;computerized tools;Coupling;cytokine;Cytokine Signaling;Data;data-driven model;Development;Directed Molecular Evolution;dynamic system;EGF gene;Engineering;Environment;Epitopes;experimental study;Goals;Immune system;information processing;Information Theory;insight;Life;Ligands;Machine Learning;Metabolism;model building;Modeling;Modernization;Molecular;molecular modeling;Mutation;NF-kappa B;novel;Nutrient;Organism;Pathway interactions;Pattern;Planet Earth;predictive modeling;programs;Proteins;receptor;Research;Sea;Signal Transduction;Signaling Protein;Specificity;Statistical Models;success;System;Systems Theory;theories;Time;Transforming Growth Factor beta;Viral;Viral Proteins;Work

PROJECT_TITLE: Revealing mechanisms of specificity and adaptability in molecular information processing through data-driven models


NIH_SPENDING_CATS: Brain Disorders;Dissemination and Implementation Research;Drug Abuse (NIDA only);Social Determinants of Health;Substance Misuse

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE In 2019, Hispanic/Latinx individuals were awarded 8.6% of the 187,568 doctoral degrees awarded in the US despite accounting for 18.5% of the US population, and African American graduates were awarded 9.2% of degrees awarded despite accounting for 12.5% of the population, a disparity which drives a lack of diversity among faculty at leading health institutions and in the field of substance use research. There is a need to focus on the necessary first step to increasing diversity in substance use treatment and prevention research: getting college-aged scholars of color who have been underrepresented in academic medicine and public health to attend graduate programs at Research 1 (R1; Carnegie very high research activity designation) institutions where rigorous training will enable independence. The primary innovation of this R25 proposal is its ability to deliberately build a substantial and sustainable pathway between six Hispanic-Serving Institutions and New York University to both identify and enroll exceptional underrepresented undergraduate students into a training program that will provide a pathway to doctoral training in substance use research at R1 institutions.

PI_NAMEs: KHAN, MARIA RABIA (contact)

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: Accounting;addiction;Address;African American;African American student;aged;Alaska Native;Area;Award;Bachelor's Degree;Biometry;Black race;career;career development;Cities;Clinical Trials Network;college;Color;Comparative Effectiveness Research;County;Dependence;design;Discipline;Disparity;Doctor of Philosophy;Doctor's Degree;Drug Addiction;Drug usage;education research;Educational Status;Educational workshop;Enrollment;Ensure;Environment;Epidemiology;Ethnic Origin;experience;Faculty;falls;First Generation College Students;Funding;Funding Mechanisms;Goals;graduate school;Health;higher education;Hispanic;Hispanic-serving Institution;HIV;implementation research;implementation science;innovation;Institution;Island;Knowledge;Latinx;Latinx population;Lead;Leadership;Life;matriculation;Medical;medical schools;Medicine;meetings;Mentors;Methods;minority undergraduate;Movement;National Institute of Drug Abuse;Native Americans;Native Hawaiian or Other Pacific Islander;New York;next generation;Opioid;Pathway interactions;peer networks;Persons;Policies;Population;population health;Postbaccalaureate;Postdoctoral Fellow;Prevention Research;programs;prospective;Public Health;Publications;racial diversity;recruit;Research;Research Activity;Research Methodology;Research Personnel;Research Training;Science;Scientist;Secure;Site;skills;skills training;Social Work;Students;Substance abuse problem;Substance Addiction;substance use;substance use treatment;suburb;System;Teleconferences;Training;Training Programs;treatment research;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;university student;Work

PROJECT_TITLE: Strengthening Pathways between Hispanic-Serving Institutions and Leadership in Addiction Science


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Palliative Care;Rural Health;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative The short-term goal of this K23 award is the development of the PI as an independent investigator skilled in the assessment and behavioral intervention, most especially focused on underrepresented and vulnerable aging populations, in rural regions who are disproportionately impacted by dementia. The proposed research will use a non-pharmacological, environmental approach to develop assessments and tailored interventions that can be delivered via telehealth to improve behaviors and activity engagement for people with dementia in their home. The long-term goal is to empower older adults with dementia to age in place within their home with minimal behavior disruption and maximum activity participation.

PI_NAMEs: RHODUS, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Active Learning;Address;Adoption;Adult;Advisory Committees;Aggressive behavior;Aging;aging in place;Agitation;Alzheimer's Disease;Alzheimer's disease related dementia;Analysis of Covariance;Anxiety Disorders;arm;Behavior;Behavior assessment;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral Model;behavioral response;Behavioral Symptoms;career;career development;Career Mobility;Caregiver Burden;caregiver education;caregiver quality of life;Caregivers;Caring;Client satisfaction;Clinic;Clinical;Clinical assessments;Clinical Trials Design;college;Communities;community based research;Country;Cues;Data;Death Rate;Dementia;dementia care;Development;Development Plans;Diagnosis;dimension reduction;empowerment;Environment;environmental intervention;evidence base;experience;Extramural Activities;Faculty;feasibility trial;Fellowship;follow-up;Fostering;Foundations;Funding;Future;Goals;Grant;health disparity;health equity;Health equity research;Health Services Accessibility;Home;Home environment;improved;in-home care;Individual;innovation;Institution;Institutionalization;Intervention;Interview;Kentucky;knowledge base;Letters;Measurement;Measures;Medicine;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Morbidity - disease rate;mortality;Neurology;Neurosciences;Nonpharmacologic Therapy;novel strategies;older adult;Pamphlets;patient home care;Performance;Persons;Physiological;Population;Positioning Attribute;Postdoctoral Fellow;programs;Protocols documentation;Proxy;psychiatric symptom;Psychiatrist;Psychophysiology;Quality of life;Randomized, Controlled Trials;Reporting;Research;Research Activity;research and development;Research Personnel;Residencies;response;Rural;Rural Appalachia;rural area;Rural Community;Safety;satisfaction;Scholarship;Science;Scientist;Single-Blind Study;skills;Sleep Disorders;social;standard of care;Stimulus;supportive environment;Surveys;Teacher Professional Development;telehealth;tenure track;Testing;therapy development;tool;Training;Underrepresented Populations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Improving Person-Environment Fit of Community-Residing Older Adults with Dementia Through Assessment and Individualized Intervention

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes;Regenerative Medicine;Wound Healing and Care

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Chronic skin wounds are a significant clinical problem, particularly in the context of diabetes. The goal of the proposed work is to develop a fully synthetic, cell-degradable wound dressing that promotes repair of nonhealing skin wounds.

PI_NAMEs: DUVALL, CRAIG LEWIS (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Acceleration;adaptive immune response;Address;Admission activity;aging population;Animal Model;Becaplermin;Benchmarking;Biocompatible Materials;Biomedical Engineering;Carbon Dioxide;Cattle;Cells;Cellular Infiltration;Cellulose;Cessation of life;Chemistry;chronic wound;Clinical;clinical application;clinical development;clinically relevant;Collaborations;Collagen;cost;Couples;crosslink;Crosslinker;Data;density;design;Devices;Diabetes Mellitus;diabetic;diabetic patient;diabetic rat;diabetic ulcer;Engineering;Equilibrium;ethylene glycol;Excision;fabrication;Family suidae;FDA approved;Formulation;Gene Expression;Generations;Glycols;Glycosaminoglycans;Goals;Granulation Tissue;healing;Health Care Costs;Healthcare Systems;Histologic;Histopathology;Hospitals;Hydrolysis;hydrophilicity;Hydrophobicity;Hydroxyl Radical;Immune;immunogenic;immunogenicity;Immunologics;Immunology;in vivo;Incidence;Infiltration;innovation;invention;Ischemia;Isocyanates;Kinetics;Lead;lead candidate;Legal patent;Length;Libraries;limb amputation;manufacture;mechanical properties;Modeling;Morbidity - disease rate;multidisciplinary;nanoparticle;Nature;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Pathologic;Phenotype;Platelet-Derived Growth Factor;Polyesters;Polymers;polyurethane foam;Polyurethanes;Porosity;pre-clinical;prisma;Process;Procollagen-Proline Dioxygenase;Property;Publications;Publishing;Reaction;Reactive Oxygen Species;Recombinants;repaired;response;scaffold;screening;Series;Side;Silicones;Silver;Site;Skin;skin wound;Small Interfering RNA;Source;Sterile coverings;success;Technology;Testing;Time;timeline;tissue repair;Tissues;translational medicine;Translational Research;Urethane;Variant;Vertebral column;Water;Work;wound;wound care;wound dressing;wound healing;Wound Infection;Wound models

PROJECT_TITLE: Bioresorbable Polythioketal Urethane Wound Dressings

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Aging;Neurosciences;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project narrative Why the repeated activation of the fight-or-flight response increases disease susceptibility and reduces lifespan is poorly understood. Using the nematode C. elegans as a model, this proposal aims to gain fundamental understanding of how stress neurohormones activate the highly conserved insulin pathway that regulates stress resistance and aging. These studies will provide crucial new insights that will inform the treatment of people suffering from stress disorders, which are associated with accelerated aging and increased susceptibility to diabetes, cardiovascular- and infectious-diseases.

PI_NAMEs: ALKEMA, MARK  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Ablation;Acute;acute stress;Address;Adolescent;Adrenergic Agents;Adult;Affect;age acceleration;Aging;analog;Animals;associated symptom;Behavioral;Binding;biological adaptation to stress;Biology;Caenorhabditis elegans;Calcium;Cardiovascular Diseases;Cells;Communicable Diseases;coping;cost;Cytoprotection;Defense Mechanisms;Development;Diabetes Mellitus;Disease;Disease susceptibility;Down-Regulation;early life stress;enhancing factor;environmental stressor;Epigenetic Process;Epinephrine;experience;experimental study;Exposure to;fighting;G-Protein-Coupled Receptors;Genes;Genetic;Goals;GTP-Binding Proteins;gut-brain axis;Health;Hormones;Human;IGF-1 Signaling Pathway;Image;Imaging Techniques;Impaired health;Impairment;in vivo;insight;Insulin;Insulin-Like Growth Factor I;insulin-like peptide;Intestinal Secretions;Intestines;Invertebrates;Life;life span;Link;Mammals;Modeling;Molecular;mutant;Nematoda;Nervous System;neural;neural circuit;Neuroglia;Neurohormones;neuromechanism;Neurons;neuroregulation;novel;optogenetics;Oxidative Stress;Pathway interactions;Peptides;Persons;Pharmacology;Physiology;Predisposition;receptor;Repression;Resistance;response;Role;Severities;Signal Transduction;Signaling Protein;Starvation;Stress;stress disorder;stress management;stress reduction;Sympathetic Nervous System;Symptoms;System;Transcend;transcription factor;Transgenes;Tyramine

PROJECT_TITLE: The impact of stress neurohormones on health and aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative The primary goal of our program is the career development of the next generation of scientific leaders in the biomedical sciences. Our program is uniquely positioned to recruit internal medicine residents of varied backgrounds and experiences to undergo mentored research training that will ultimately help to foster highly diverse and skilled physician-investigators. Our strong mentorship platform derives from a large group of senior investigators who are leaders in multidisciplinary research and emphasize novel investigative approaches in an ethical and scientifically responsible environment.

PI_NAMEs: DUDEK, STEVEN M;JACOBSON, JEFFREY R (contact);MCCAULEY, MARK D

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: African American population;Area;base;Basic Science;career;career development;Chicago;Clinical;clinical development;Clinics and Hospitals;Collaborations;college;Dedications;design;Development;Discipline;Education;Educational Curriculum;Elements;Environment;Ethics;expectation;experience;Faculty;faculty mentor;Fostering;Foundations;Future;global health;Goals;Grant;Growth and Development function;Health;health care service;high risk population;Hispanic;Illinois;Infrastructure;inner city;innovation;Interdisciplinary Study;interest;Internal Medicine;Latinx;Leadership;Life Experience;Medical center;Medicine;Mentors;Mentorship;metropolitan;Mission;National Heart, Lung, and Blood Institute;next generation;novel;Outcome;Patient Care;Patients;Physicians;Population;Positioning Attribute;Program Evaluation;programs;prospective;recruit;Research;Research Personnel;Research Project Grants;Research Training;Residencies;responsible research conduct;Role;Science;skills;synergism;Talents;Technology;Time;Training;trend;Underrepresented Minority;United States Department of Veterans Affairs;Universities;Urban Health;Work;Workforce Development

PROJECT_TITLE: Fostering Academic Physician-Investigators Treating High Risk Populations


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Biotechnology;Cancer;Lung;Lung Cancer;Prevention;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative  Small cell lung cancer (SCLC) is a highly aggressive, recalcitrant, and deadly cancer that can only be effectively treated if fortuitously detected early; however, no early detection protocol exists. We have discovered that the presence of tumor-specific autoantibodies can accurately predict SCLC earlier. Radioimmunoconjugates based on these autoantibodies could also be used to image SCLC tumors, creating a paradigm in which the early detection of SCLC biomarkers circulating in blood triggers targeted PET imaging and treatment.

PI_NAMEs: CHEN, DELPHINE L;LAMPE, PAUL D. (contact);ZEGLIS, BRIAN MATTHEW

PROGRAM_OFFICER_NAME: MAZURCHUK, RICHARD V

PROJECT_TERMS: Address;American;Antibodies;Antigens;Autoantibodies;Autoantigens;Autoimmune Responses;Autoimmunity;B-Lymphocytes;Benefits and Risks;Binding;Biodistribution;Biological Assay;Biological Markers;Blood;Blood Tests;Cancer Patient;cell immortalization;Cell Line;Cell membrane;Cell surface;Cessation of life;Chelating Agents;circulating biomarkers;Clinic;Clinical;cohort;Complex;computed tomography screening;Data;density;Detection;Development;Diagnosis;diagnostic biomarker;diagnostic platform;Disease;early detection biomarkers;Early Diagnosis;Early Intervention;early screening;Eligibility Determination;Ensure;Epitopes;Excision;experimental study;expression vector;first-in-human;fluorodeoxyglucose;fluorophore;Future;Guidelines;high risk;high risk population;Human;human monoclonal antibodies;human tissue;humanized monoclonal antibodies;Image;imaging agent;imaging modality;immune imaging;Immunoconjugates;improved;in vivo;Label;Limited Stage;Location;low dose computed tomography;Lung;lung cancer screening;Malignant Neoplasms;Mediastinal;Mediating;men;Monoclonal Antibodies;mortality;mouse model;neoantigens;Nerve Tissue;Neuroendocrine Cell;Neurologic;non-invasive imaging;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;Operative Surgical Procedures;Outcome;Pathway interactions;patient derived xenograft model;Patients;Performance;Persons;Plasma;Population;Positron-Emission Tomography;Post-Translational Protein Processing;Pre-Clinical Model;preclinical study;Primary Neoplasm;Production;protein expression;Proteins;Protocols documentation;Radioimmunoconjugate;Radioisotopes;Recombinant Antibody;Recommendation;Reproducibility;Resected;Risk Factors;risk stratification;Role;Sensitivity and Specificity;Site;small cell lung carcinoma;Smoker;Smoking;SPINK1 gene;standard of care;subcutaneous;Survival Rate;Syndrome;targeted imaging;Testing;TFRC gene;Therapeutic Intervention;therapy resistant;TIMP2 gene;Translating;Translations;tumor;Tumor stage;Tumor-Derived;United States Preventative Services Task Force;Woman;Xenograft Model

PROJECT_TITLE: Autoantibodies to tumor-derived neoepitopes as biomarkers and immunoPET agents for the early detection of small cell lung cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-L(59)R]


NIH_SPENDING_CATS: Brain Disorders;Complementary and Integrative Health;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Drug-resistant epilepsy is a debilitating disease that affects millions of people. One of the most effective treatments is dietary therapy that changes brain metabolism, but the mechanism by which this difficult diet prevents seizures remains poorly understood. This study uses gene alteration in a mouse to produce a similar metabolism-based seizure resistance, and to define the molecular and cellular mechanism for this seizure resistance and discover pharmacological tools that mimic it, with the ultimate goal of finding new therapeutic approaches that exploit this anticonvulsant mechanism.

PI_NAMEs: YELLEN, GARY I (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acute;Affect;Animals;Anticonvulsants;Antioxidants;Apoptosis Regulation Gene;Apoptotic;ATP sensitive potassium channel complex;Bad protein;Biosensor;Brain;brain cell;brain metabolism;Carbohydrates;Carbon;Caregivers;Cells;Cellular Metabolic Process;Chronic;Convulsants;Data;Diet;Diet therapy;dietary;Disease;effective therapy;Effectiveness;Energy Metabolism;enzyme activity;Epilepsy;Equilibrium;Event;Exhibits;experience;Gene Mutation;Genes;Genetic;Genetic Models;Glucose;Glycolysis;Goals;Grant;in vivo;inhibitor;inorganic phosphate;Intervention;Intractable Epilepsy;Ion Channel;ketogenic diet;Ketone Bodies;Knock-out;Label;Metabolic;Metabolism;Modeling;Molecular;Monitor;mouse genetics;mouse model;Mus;Mutation;NADP;neuronal excitability;Neurons;novel therapeutic intervention;novel therapeutics;Oxidation-Reduction;Oxygen;Pathway interactions;Pentosephosphate Pathway;Persons;pharmacologic;Point Mutation;Potassium Channel;Predisposition;prevent;Probability;Production;public health relevance;Resistance;response;Reverse engineering;Role;Seizures;Signal Transduction;Slice;Source;Status Epilepticus;Testing;Therapeutic;tool;Work

PROJECT_TITLE: Mechanisms of Seizure Resistance in a Mouse Genetic Model with Altered Metabolism

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Genetic changes in the single gene, MYH7, which encodes the major motor protein in the heart, cause a variety of human heart diseases, called cardiomyopathies. Up to 1/250 individuals carries a genetic change in this gene. Through this work, we will detail why specific genetic defects cause a specific type of developmental heart disease which manifest as cardiomyopathies, and this information will help identify and reduce disease risk.

PI_NAMEs: MONROE, TANNER O (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;adjudication;Alleles;biobank;Bioinformatics;Cardiac;Cardiac Myocytes;cardiac tissue engineering;cardiogenesis;Cardiomyopathies;cardiovascular health;career development;Cell Cycle;Cell Line;Cells;Childhood;Code;cohort;Complex;Cytoskeleton;Data;Data Discovery;Data Set;Defect;Development;Development Plans;Developmental Biology;developmental genetics;deviant;Dilated Cardiomyopathy;Disease;disorder risk;DNA sequencing;Educational workshop;Electronics;Equity;Family;Functional disorder;Future;General Population;Genes;Genetic;genetic approach;genetic architecture;genetic variant;Genetic Variation;genome editing;Genomics;Genotype;Hand;Head;Health;Heart;Heart Diseases;heart imaging;Heterogeneity;Heterozygote;Human;Human Engineering;human induced pluripotent stem cells;human tissue;Hypertrophic Cardiomyopathy;Impairment;improved;in vivo;indexing;Individual;induced pluripotent stem cell derived cardiomyocytes;inherited cardiomyopathy;Investigation;Left ventricular non-compaction;Link;loss of function;Loss of Heterozygosity;Mediating;Medical;Mentors;Methods;Modeling;Molecular;Motor;Mutation;Myosin ATPase;Myosin Heavy Chains;N-terminal;Non-compaction cardiomyopathy;Outcome;Pathogenicity;Pathway interactions;Performance;Phase;Phenocopy;Phenotype;pleiotropism;Population;Population Study;premature;Prevalence;Productivity;Proliferating;Proteins;Publications;Research;Resources;risk variant;Sarcomeres;Secondary to;Series;Signal Transduction;single-cell RNA sequencing;skills;Specific qualifier value;Study models;Testing;Tissue Engineering;Tissues;Training;Training Programs;trait;transcriptomics;United States National Institutes of Health;Variant;variant of unknown significance;Work

PROJECT_TITLE: Mechanisms linking the frail sarcomere to noncompaction cardiomyopathy

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) are highly aggressive and genetically complex B-cell lymphomas. Standard treatment with high-intensity chemotherapy leads to treatment- related mortality in approximately 10% of patients and fails to cure approximately 36-40% of patients. Investigating the genetic, epigenetic and immunological etiology of BL may inform future rational therapeutic strategies, and is likely to improve the outcome of these patients and have a substantial impact on public health.

PI_NAMEs: GREEN, MICHAEL RICHARD (contact);MASON, CHRISTOPHER EDWARD

PROJECT_TERMS: Adopted;Affect;Alleles;Animals;ARID1A gene;Automobile Driving;B cell differentiation;B lymphoid malignancy;B-Cell Development;B-Cell Lymphomas;B-Lymphocytes;Binding Sites;Biology;Bladder;Burkitt Lymphoma;Catalytic Domain;Cell Communication;Cell Line;Cells;Characteristics;chemotherapy;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;cohort;Complex;conditional knockout;Darkness;Dependence;Disease;Disease Progression;driver mutation;Enhancers;Epigenetic Process;epigenetic regulation;Etiology;Failure;Family;Frequencies;Future;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genomic approach;Genomics;Histologic;Human;immunological synapse;immunological synapse formation;Immunologics;improved outcome;insight;Knockout Mice;large cell Diffuse non-Hodgkin's lymphoma;Lead;Light;loss of function;Lymphoma;Lymphomagenesis;Malignant - descriptor;Malignant Neoplasms;Maps;Modeling;Molecular;Molecular Analysis;mortality;Mutation;Nucleosomes;Organoids;Outcome;overexpression;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pattern;Phenotype;Play;precision medicine;prevent;Process;programs;Progression-Free Survivals;promoter;protein expression;Public Health;Reaction;Recurrence;Refractory;Regulatory Element;RELA gene;response;rituximab;Role;Signal Transduction;SMARCA4 gene;Somatic Mutation;SPI1 gene;standard care;Stomach;Structure of germinal center of lymph node;T-Lymphocyte;targeted treatment;Therapeutic;TNFRSF5 gene;tositumomab;Toxic effect;transcription factor;Transcriptional Activation;transcriptome sequencing;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumor-immune system interactions;Uterus;Work

PROJECT_TITLE: BAF complex deregulation in lymphoma

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Timely diagnosis of dementia remains a challenge for Black American populations contributing to high prevalence of moderate to severe Alzheimer’s. This proposal will adapt and implement an intervention to increase dementia literacy and provide pre-care setting skills training in goals of care conversations.

PI_NAMEs: SLOAN, DANETTA ELIZABETH HENDRICKS (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Advance Care Planning;Advocate;African American Women;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Attitude;Award;Awareness;Behavior;Benefits and Risks;Black American;Black church;Black Populations;Black race;care providers;career;career development;Caring;caucasian American;Church;Cognitive;Communication;communication behavior;Communities;community based research;Complex;Comprehension;Conflict (Psychology);Decision Making;decision-making capacity;Dementia;dementia care;design;Diagnosis;Disease;Distress;Early Diagnosis;Education;Educational Curriculum;Educational workshop;Ensure;evidence base;experience;Experimental Designs;Faith;Family;Focus Groups;Future;Goals;Growth;Health;health literacy;Healthcare;High Prevalence;Home;Hospice Care;Image;implementation science;improved;Individual;Inequity;Institution;Intervention;intervention refinement;Interview;Knowledge;Legal;Life;literacy;Literacy Programs;loved ones;Manuscripts;Medical;Mentors;Mentorship;Modeling;Morbidity - disease rate;mortality;Outcome;patient home care;Patients;Persons;Phase;Population;pre-clinical;preference;Preparation;Quality of Care;Quality of life;Readiness;Research;Research Methodology;Research Personnel;Resources;satisfaction;Scientist;Self Efficacy;Services;Signs and Symptoms;skills;skills training;Social Workers;Societies;Source;surrogate decision maker;surrogate decision making;Testing;therapy design;Training;Translating;Treatment Efficacy;Trust;United States National Institutes of Health;uptake;Work

PROJECT_TITLE: Video intervention to improve dementia literacy and goal of care conversations for Black Americans

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]