NIH_SPENDING_CATS: Aging;Clinical Research;Genetics;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Kidney Disease;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative: Although antiretroviral therapy (ART) results in successful suppression of HIV and a decrease of AIDS progression, a substantial proportion of people living with HIV have elevated risk for chronic kidney disease, which leads to increased mortality. To thoroughly investigate the molecular system influencing kidney function and disease, we will conduct a longitudinal study using multi-omics approaches (i.e., epigenomics, genomics and transcriptomics) and methods of causal inference. This study aims to identify and replicate epigenomic markers and their related molecular functions to understand inter-individual variability of kidney function and chronic kidney disease, and to identify novel targets for improved treatment and prevention among people living with HIV of African ancestry.

PI_NAMEs: MARCONI, VINCENT CHARLES;SUN, YAN  (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;African American population;African ancestry;Aging;AIDS-Associated Nephropathy;antiretroviral therapy;Apolipoproteins;autosome;Biological;Biological Process;biological systems;Body mass index;Chronic Disease;Chronic Kidney Failure;cigarette smoking;Clinical;co-infection;Cohort Studies;comorbidity;Complication;Cross-Sectional Studies;Data;design;Development;Diabetes Mellitus;Diagnosis;Disease Outcome;DNA Methylation;End stage renal failure;Environment;Environmental Risk Factor;epigenetic clock;epigenetic marker;Epigenetic Process;epigenetic variation;epigenome;epigenome-wide association studies;epigenomics;experience;Exposure to;Filtration;functional genomics;Future;Gene Expression;Genes;Genetic;Genetic Variation;Genome;Genomics;Glomerular Filtration Rate;high risk;HIV;HIV Infections;HIV-2;HIV/AIDS;Human;human disease;Hypertension;Immune response;improved;Incidence;Individual;Infection;inter-individual variation;Kidney;Kidney Diseases;kidney dysfunction;Knowledge;Learning;Life Expectancy;life span;Link;longitudinal analysis;Longitudinal Studies;Measures;Mediating;Mediation;Mendelian randomization;Methods;Modeling;Modification;Molecular;mortality;multiple omics;novel;Outcome;Pathogenesis;Pathology;Pathway interactions;Persons;Physiological;Play;Population;precision medicine;predictive marker;Prevention;Prognosis;Regimen;Renal function;Research;Risk;Risk Factors;risk stratification;risk variant;Role;Site;superinfection;System;Therapeutic;Time;transcriptome;transcriptome sequencing;transcriptomics;Variant;Veterans;Viremia

PROJECT_TITLE: Multi-omic Predictors of Renal Function among HIV-infected Individuals of African Ancestry

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLUMBIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: RNA structures and interactions hold the key to many important biological processes. This project develops cutting-edge computational methods for the predictions of RNA structures and interactions. The results from the project will lead to novel computational tools for understanding disease mechanism at molecular level and for the rational design of RNA-based therapeutics. !

PI_NAMEs: CHEN, SHI-JIE  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Benchmarking;Biochemical;Biological Process;Biology;Biotechnology;Cell Physiology;Charge;Computer Models;computerized tools;Computing Methodologies;Cryoelectron Microscopy;Data;Data Analyses;Databases;deep learning;design;Disease;Drug Interactions;experimental study;FDA approved;Gene Expression;Gene Expression Regulation;gene therapy;genomic RNA;Goals;Grant;Hepatitis C virus;HIV;Hybrids;Ions;Kinetics;Knowledge;Metal Ion Binding;Metals;Methods;Microbiology;Modeling;Molecular;novel;novel strategies;Physics;Play;polyanion;precision medicine;predictive tools;rational design;RNA;RNA Computations;Role;Scientist;simulation;Site;Structure;synthetic biology;System;Testing;Therapeutic;therapeutic RNA;tool;United States National Institutes of Health;virology

PROJECT_TITLE: New methods for computational modeling of RNA structures

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(55)R]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infant Mortality;Machine Learning and Artificial Intelligence;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative Care and outcomes for vulnerable premature babies varies widely. While many of these babies are cared for in regionalized hospital networks, assessments of the quality of these networks has been held back by a lack of appropriate analytic tools. We propose to address this gap, using network analysis and machine learning to graphically and mathematically describe how well regionalized hospital networks function.

PI_NAMEs: PROFIT, JOCHEN  (contact);ROGOWSKI, JEANNETTE A;ZITNIK, MARINKA

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Address;Administrator;Adult;adverse outcome;analytical tool;Back;California;care delivery;care outcomes;Caring;Characteristics;Chronic lung disease;Clinical;clinical care;Data;Data Set;Data Sources;density;design;Dimensions;Effectiveness;Equity;Ethnic Origin;Ethnic Population;Evolution;experience;Family;financial incentive;Funding;Geographic Factor;Geography;Gestational Age;Goals;graph theory;Guidelines;Health;health equity;Health Services;Health system;high risk infant;Hospital Administrators;Hospitals;improved;Individual;Inequity;Infant;Infant Care;innovation;Institution;Insurance;Insurance Carriers;intraventricular hemorrhage;Joints;Lead;Length of Stay;Link;Machine Learning;machine learning algorithm;Maps;Mathematics;Measures;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Necrotizing Enterocolitis;Neonatal;Neonatal Intensive Care Units;Neonatal Mortality;neonatal outcome;novel;Observational Study;Outcome;Output;Pathway Analysis;Patient Care;Patient Discharge;Patients;Pattern;Patterns of Care;Performance;Perinatal;Perinatal Care;Policy Maker;Population;population based;Positioning Attribute;postnatal;Premature Infant;primary outcome;Provider;Quality of Care;Race;Recommendation;Records;Research;Research Infrastructure;Research Personnel;Resources;Retinopathy of Prematurity;Risk;Sampling;Science;secondary outcome;Services;Shapes;social;social factors;Structural Racism;Structure;System;Techniques;Testing;Time;tool;United States;United States National Institutes of Health;Variant;Very Low Birth Weight Infant;Visual;Visualization;Work

PROJECT_TITLE: Measuring Neonatal Regionalization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Lupus;Precision Medicine;Prevention

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The successful completion of the MONA-LISA project will provide detailed knowledge of the immunological, genomic, and metabolic characteristics of people who are at risk for the development of systemic lupus erythematosus and subsequently go on to develop the disease. This will enable clinical researchers to develop better clinical trials to test novel therapies that prevent the development of autoimmune diseases such as lupus. These data will also allow health care providers to better diagnose patients with early lupus features before they develop permanent organ damage and disability.

PI_NAMEs: GUTHRIDGE, JOEL MARVIN;KARP, DAVID R (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Anti-malarials;Antinuclear Antibodies;Atlases;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;B cell repertoire;B-Lymphocytes;Biological Markers;Black Populations;Blinded;Blood specimen;Categories;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;chemokine;Classification;Clinical;Clinical assessments;Clinical Data;clinical phenotype;Clinical Trials;cohort;Cutaneous Involvement;cytokine;Data;Data Set;Development;Diagnosis;diagnostic tool;disability;Disease;disorder prevention;DNA;Double-Blind Method;Down-Regulation;effective intervention;Enrollment;Epidemiology;Epigenetic Process;epigenomic profiling;epigenomics;Ethnic Population;Expression Profiling;Gene Expression Regulation;Genetic Polymorphism;Genomics;Goals;Health Personnel;Health Transition;high dimensionality;Hydroxychloroquine;Immune response;Immune system;Immunologics;Immunophenotyping;immunoregulation;Individual;Intention;Intervention Trial;Investments;Knowledge;Laboratories;Learning;lipidomics;Lipids;Lupus;Lupus Erythematosus;Measurement;Mediating;Mediator;Messenger RNA;Metabolic;metabolomics;mRNA Expression;multiple omics;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;new therapeutic target;Not Hispanic or Latino;novel;novel therapeutics;Observational Study;Organ;Participant;Pathogenesis;Pathway interactions;Patient Outcomes Assessments;Patients;Performance;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;phase 2 study;Placebo Control;Plasma;Population;Populations at Risk;Portraits;prevent;Prevention;primary endpoint;prognostic tool;Proteomics;Protocols documentation;Randomized;Recording of previous events;recruit;Research Personnel;Resources;response;Risk;Risk Assessment;risk variant;RNA;Role;screening;Serology;Serum;single cell ATAC-seq;single-cell RNA sequencing;Specimen;Standardization;Systemic Lupus Erythematosus;Systems Analysis;T-Lymphocyte;Testing;tool;transcriptomics;United States National Institutes of Health;Urine;Variant;Work

PROJECT_TITLE: Mechanisms of New-Onset Autoimmunity/Longitudinal Immune Systems Analysis (MONA-LISA)


ADMINISTERING_IC: MD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: MAPLE GROVE

ORG_NAME: ADVANCED MEDICAL ELECTRONICS CORPORATION

ORG_STATE: MN

PHR: Project Narrative Parkinson's disease is the second most common neurodegenerative disease, affecting 1% of Americans older than 65. Parkinson's disease is a complex disease affecting a wide range of organ systems and impacting patients in a variety of ways. The motor features of Parkinson's disease including tremor, gait and balance dysfunction are well known, but non-motor features of Parkinson's disease such as those affecting cognition, sleep, and gut absorption are wide ranging and less well known but have a significant impact on patient quality of life. The management of Parkinson's disease is complex and subspecialty care by a movement disorders neurologist is important for extending quality of life for as long as possible. This project seeks to develop improved technology for use in rural environments to aid in the diagnosis and management of Parkinson's disease patients.

PI_NAMEs: HAVEY, GARY D (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: absorption;Academic Medical Centers;Accelerometer;Affect;American;arm;Back;Body System;Bradykinesia;Calibration;Caring;Cellular Phone;Cognition;Complex;Computer software;Computers;Data;Deep Brain Stimulation;design;Development;Devices;Diagnosis;Disease;Distal;Early Diagnosis;Electrical Engineering;Engineering;Equilibrium;Essential Tremor;experience;Farm;Fingers;Forearm;Functional disorder;Gait;Galvanic Skin Response;glucose sensor;Hand;Hearing Aids;Hospitalization;human old age (65+);improved;innovation;instrumentation;Internet;Location;Low income;Measurement;Medical;Medical Electronics;medical specialties;Minnesota;Monitor;Morbidity - disease rate;Motion;Motor;Movement;Movement Disorders;Neurodegenerative Disorders;Neurologist;Neurosurgeon;Occupational Therapist;Onset of illness;Operative Surgical Procedures;Parkinson Disease;Patients;Performance;Persons;Pesticides;Pharmaceutical Preparations;Phase;Primary Care Physician;Process;profession allied to medicine;Pronation;Protocols documentation;Quality of life;Radio;Records;reduce symptoms;Remote management;research and development;research clinical testing;Rest;Rest Tremor;Rural;rural area;rural environment;Rural Population;rural underserved;Screening procedure;Secure;sensor;Sleep;social stigma;Specialist;Speech;Supination;symptom management;System;Technology;Time;tool;Training;Tremor;Universities;urban area;usability;Visit;wearable device;wearable sensor technology;wireless;Work;Wrist

PROJECT_TITLE: Ring wearable sensor use for diagnosis and monitoring of Parkinson's disease in underserved rural populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 JT (A1)]


NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Genetics;Human Genome;Neurosciences;Physical Rehabilitation;Precision Medicine;Rehabilitation;Stroke

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE/PUBLIC HEALTH RELEVANCE  The proposed research is relevant to public health because it will inform stroke rehabilitation practices that can reduce the burden of neurological disorders and enhance the quality of life for people with disabilities. This work also addresses high-priority research areas identified by NIH/NCMRR to (i) develop objective measures of rehabilitation treatment response and functional progress and (ii) promote discovery of biomarkers that predict rehabilitation treatment response and enable the tailoring of interventions to the needs, abilities, and resources of the person with disability.

PI_NAMEs: BRAUN, ROBYNNE  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: acute stroke;Address;Animal Model;Animals;Area;Award;Biological;Biological Markers;Biological Process;biomarker discovery;Blood;Blood - brain barrier anatomy;brain tissue;Candidate Disease Gene;career;Cell Differentiation process;Cell Proliferation;cell type;Cells;Chemotaxis;Chronology;Communities;Corticospinal Tracts;Cross-Sectional Studies;Cytoskeletal Modeling;Data;database of Genotypes and Phenotypes;differential expression;Disabled Persons;Event;Flow Cytometry;functional outcomes;Funding;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Research;Genetic Transcription;genome repository;genomic data;Genomic medicine;Genomics;Goals;Hour;Immune;Immune response;Immunologics;Individual;Inflammation;innovation;Interdisciplinary Study;Intervention;Ischemic Stroke;Limb structure;Literature;Lymphocyte;Maryland;Measures;Medical Research;Methodology;Methods;Molecular;monocyte;Motor;Motor Evoked Potentials;motor impairment;motor recovery;Nervous System Disorder;neural repair;neuroinflammation;neurological rehabilitation;neutrophil;next generation sequencing;novel;optimal treatments;Pathway interactions;Patients;Pattern;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;personalized approach;personalized medicine;Phase;phenotypic data;plexin;post stroke;Pre-Clinical Model;predictive marker;programs;Public Health;public health relevance;Quality of life;Recovery;recruit;rehabilitation research;Rehabilitation therapy;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Resources;response;Semaphorins;Severities;Signal Transduction;Stroke;stroke outcome;stroke recovery;stroke rehabilitation;System;Technology;Time;timeline;Tissue-Specific Gene Expression;Transcript;transcriptome sequencing;transcriptomics;treatment response;United States National Institutes of Health;Universities;Vascular Endothelial Growth Factors;WNT Signaling Pathway;Work

PROJECT_TITLE: Transcriptional Profiling of the Post-Stroke Immune Response to Tailor Rehabilitation Timelines

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-G (57)]


ADMINISTERING_IC: HS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: OVERALL - NARRATIVE The Washington LHS E-STAR Center will build a consortium of research organizations that are leaders in LHS training and research, and diverse primary care organizations (PCOs) across the state, where early career scientists receive training and mentorship for the purpose of transforming primary care. The Center will (1) build new infrastructure for bidirectional research-health care partnerships, (2) train 7 early-career researchers in embedded LHS research in partnership with PCO leaders, and (3) lead embedded LHS research in participating PCOs. These activities will enable the Center to achieve its goals of producing a diverse set of independent scientists with a solid foundation in LHS research who can change the paradigm of primary care research through research that rapidly develops and implements evidence; and simultaneously building LHS capacity in safety net primary care settings.

PI_NAMEs: LOZANO, PAULA  (contact);RALSTON, JAMES D.

PROGRAM_OFFICER_NAME: GRIFFIOEN, MARI

PROJECT_TITLE: Washington Learning Health System Embedded Scientist Training and Research Center (WA LHS E-STAR Center)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHS1 HSR-B (01)]


PHR: Project Narrative not required for this component.

PI_NAMEs: LOZANO, PAULA  (contact)

PROJECT_TITLE: Admin Core - WA LHS E-STAR


PROJECT_TITLE: Research Education Core (REC) - WA LHS E-STAR


PROJECT_TITLE: Research and Data Analysis Core (RDAC) - WA LHS E-STAR


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: ROCHESTER

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Narrative This project will establish the Translational Center for Barrier MPS (TRaCe-bMPS). The Center will create five device platforms focused on dysregulated barrier function in disease and seek FDA approval for each as a qualified drug development tool (DDT).

PI_NAMEs: ADAMO, JOAN E;AWAD, HANI A;MCGRATH, JAMES L (contact);MILLER, BENJAMIN L;TRUSKEY, GEORGE A

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: Address;Advanced Development;Affect;Archives;arm;Autoimmune Diseases;Automation;Biological Assay;Biological Markers;Biological Models;Biological Process;Cells;Central Nervous System Diseases;Characteristics;Clinical;clinical translation;Collaborations;commercialization;data infrastructure;data sharing;data standards;design;Development;Devices;Disease;Drug Delivery Systems;Drug Design;drug development;drug discovery;Drug Targeting;efficacy evaluation;Ensure;experience;Feedback;Fibrosis;flexibility;Glass;Goals;Image;industry partner;Infection;Injury;Laboratories;Letters;Liquid substance;live cell imaging;manufacture;Manufacturer;Medicine;Membrane;microphysiology system;Mission;Molecular;multidisciplinary;Musculoskeletal;nanomembrane;National Center for Advancing Translational Sciences;Online Systems;Optics;Osteomyelitis;Outcome;Outcome Study;Pathology;Permeability;Pharmaceutical Preparations;Pharmacologic Substance;Physiological;Physiology;Play;Procedures;Process;programs;Protocols documentation;Qualifying;Reader;Reagent;Regulatory Affairs;Reporting;Reproducibility;Resource Sharing;Resources;response;Role;Sampling;Scientist;sensor;sensor technology;Sepsis;Silicon;Specific qualifier value;System;Technology;technology development;Testing;Thick;Tissue Microarray;Tissue Model;Tissues;tool development;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: A Translational Center for Barrier MPS

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 TC-9 (01)]


NIH_SPENDING_CATS: Aging

PI_NAMEs: MCGRATH, JAMES L (contact)

PROJECT_TERMS: arm;Autoimmune Diseases;Biological;Biometry;Cells;Central Nervous System Diseases;Charge;clinical translation;Collaborations;commercialization;Communication;Data;data integration;data management;Data Management Resources;Data Set;Decision Making;Development;Disease;disease model;drug development;drug discovery;Drug Packaging;Drug Utilization;Ensure;Evaluation;fabrication;Faculty;Feedback;Fibrosis;flexibility;Fostering;Funding;Glass;Goals;Human Resources;Individual;induced pluripotent stem cell;Industrialization;Industry;industry partner;innovation;Intellectual Property;Lead;Leadership;Legal patent;Letters;manufacture;meetings;Membrane;microphysiology system;Modeling;Musculoskeletal;nanomembrane;National Center for Advancing Translational Sciences;new technology;Optics;Osteomyelitis;Outcome;Pathology;Permeability;Play;Process;programs;Progress Reports;Qualifying;Quality Control;Regulatory Affairs;Research;Research Activity;Research Personnel;Resolution;Resource Development;Resources;Role;Schedule;sensor;Sepsis;Services;Silicon;Structure;success;Technology;Thick;Tissue Microarray;Tissues;tool development;Translating;Translational Research;United States National Institutes of Health;Universities;Validation;Work

PROJECT_TITLE: Administrative Core


PROJECT_TITLE: MPS Resources Section


NIH_SPENDING_CATS: Aging;Clinical Research

PROJECT_TERMS: Address;Adoption;Affect;arm;Autoimmune Diseases;Biological Assay;Biological Markers;Categories;cell type;Cells;Central Nervous System Diseases;Characteristics;Communicable Diseases;Communities;Cultured Cells;Data;Data Analyses;Data Collection;data format;Databases;Deposition;design;Development;Disease;disease model;drug development;drug discovery;drug efficacy;Drug Evaluation;Drug Targeting;Effectiveness;efficacy evaluation;efficacy study;Extracellular Matrix;Feedback;Fibrosis;flexibility;functional outcomes;Gene Expression;Goals;Health;Human;imaging system;improved;induced pluripotent stem cell;Infection;Inflammation;Inflammatory;insight;Laboratories;Letters;Literature;Measurement;Measures;member;Membrane;Methods;microphysiology system;Microscopy;Musculoskeletal;operation;Optics;Osteomyelitis;Output;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Pharmacotherapy;prevent;Procedures;Process;programs;prospective;Protocols documentation;Publishing;Qualifying;Reporting;Reproducibility;Resources;response;Role;Running;Scientist;Sepsis;Series;Silicon;specific biomarkers;Structure;System;Technology;Testing;Thinness;time use;Tissue Microarray;Tissue Model;Tissues;tool development;Training;Universities

PROJECT_TITLE: MPS Qualifications


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative  Chronic itch is a debilitating disease that can have serious clinical consequences. Our studies suggest that the sensory neuron expressed MrgprA1 and its human homolog MRGPRX4 are novel itch receptors and contribute to multiple chronic itch conditions including medication caused itch side effect, allergic contact dermatitis, and uremic itch. Therefore, functional analysis of MrgprA1/X4 will not only provide a mechanistic understanding of itch but also open new avenues for the development of novel itch therapeutics.

PI_NAMEs: DONG, XINZHONG  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Adenine;afferent nerve;Afferent Neurons;Agonist;Allergens;Allergic Contact Dermatitis;American;antagonist;Anticonvulsants;Antihistamines;associated symptom;Behavioral Model;Bile Acids;bile duct;Bilirubin;Binding;Biological Assay;Cholestasis;chronic itch;Chronic Kidney Failure;Clinical;Complex;Data;debilitating symptom;Development;Dinitrochlorobenzene;Disease;Electrophysiology (science);Family;Funding;G-Protein-Coupled Receptors;Goals;Hemodialysis;Histamine;Homologous Gene;Human;Image;In Vitro;in vivo;Inflammation;Injections;insight;interdisciplinary approach;Irritant Dermatitis;Kidney Diseases;Kidney Failure;Knockout Mice;Knowledge;Life;mast cell;Mediating;Mediator;member;Modeling;Molecular;mortality;mouse genetics;mouse model;Mus;Neurons;neuropeptide FF;novel;Oxazolone;Pathogenesis;Pathologic;Pathway interactions;patient screening;Patients;Peptides;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenytoin;Plasma;Play;pruriceptive neurons;Pruritus;Quality of life;receptor;Research;Rhus radicans;Role;Sampling;side effect;Skin;skin disorder;solute;Spinal Ganglia;Stimulus;Symptoms;Testing;Therapeutic;Uremia;wasting

PROJECT_TITLE: Functional Analysis of Mrgpr Family in itch sensation

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Public Health Relevance/Narrative Ourproposed research is highly relevant to public health because it willprovide fundamental knowledge about molecular mechanisms regulating astrocytic scar progression and promising new targets for treating chronic SCI. We will investigate functions of long noncoding RNAs and their target genes and pathways in astrogliosis after SCI usingcutting-edge technology and innovative research strategies.These studies are important for developing novel therapeutic interventions to improve the injury environment and facilitate axonal regeneration.

PI_NAMEs: WU-HUBER, JIAQIAN  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Adult;Anatomy;Anti-sense RNA;Astrocytes;astrogliosis;Attenuated;axon regeneration;Behavioral;Binding;Biological Assay;Biology;Bromodeoxyuridine;Cells;ChIP-seq;Chronic;Cicatrix;Code;Complex;CSPG3 gene;Data;Dependovirus;Development;druggable target;Environment;experience;experimental study;Functional disorder;functional improvement;functional outcomes;Funding;Gene Expression;Genes;genetic manipulation;Genome;genome-wide;Genomics;Glial Fibrillary Acidic Protein;Goals;improved;In Vitro;in vivo;Injections;Injury;innovation;Integrins;interest;Interruption;knock-down;Knowledge;Lesion;Luciferases;Measurement;Molecular;Molecular Target;Morphology;mouse model;nerve injury;Nerve Regeneration;neuroprotection;neutralizing antibody;novel;novel therapeutic intervention;overexpression;Pathway interactions;Phase;Phenotype;phosphacan;Play;Proliferating;Promoter Regions;protein profiling;Proteins;Public Health;public health relevance;Regulation;Regulatory Pathway;Research;Research Personnel;RNA;Role;small hairpin RNA;Spinal;Spinal Cord;Spinal cord injury;Stains;STAT3 gene;Technology;Testing;Therapeutic;therapeutically effective;Time;transcriptome sequencing;Transgenic Mice;Untranslated RNA;Virus

PROJECT_TITLE: Identifying Novel Molecular Targets for Chronic SCI

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Diabetes;Regenerative Medicine;Wound Healing and Care

ORG_CITY: BEVERLY HILLS

ORG_NAME: SCARLESS LABORATORIES, INC.

PHR: PUBLIC HEALTH RELEVANCE Up to 25% of diabetic patients develop chronic non-healing ulcers in their lifetime, which present significant infection risks given the poor vascularity and immunodeficiency related to diabetes. More generally, chronic non-healing wounds affect an estimated 6.5 Million Americans with annual cost of $50 billion dollars. This project seeks to develop an effective, novel peptide-based treatment to promote wound healing and to improve the quality of life for patients suffering from chronic wounds, especially in the diabetic populations.

PI_NAMEs: SOO, CHIA ;ZHENG, ZHONG  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acceleration;acute wound;Adverse effects;Affect;Allografting;American;Amputation;Anatomy;angiogenesis;Animal Model;Animals;antimicrobial;Area;Becaplermin;Biological;Blood Glucose;blood glucose regulation;Blood Vessels;California;Cause of Death;cell motility;Cell Physiology;Cells;Cessation of life;Chronic;chronic ulcer;chronic wound;Cicatrix;Clinic;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;commercialization;cost;Data;Debridement;Defect;Development;Diabetes Mellitus;diabetic;diabetic patient;diabetic ulcer;diabetic wound healing;Diagnosis;Dose;Endothelial Cells;Ensure;Epidemic;Extracellular Matrix;Family suidae;Female;fetal;Fibroblasts;fibromodulin;first-in-human;Formulation;Funding;Goals;Good Manufacturing Process;Grant;Granulation Tissue;Growth Factor;Histologic;Human;Immunity;immunodeficiency;Impaired wound healing;Impairment;improved;In Vitro;Incidence;Incubators;Infection;infection risk;Infiltration;Infrastructure;Injury;innovative technologies;insulin signaling;lifestyle factors;limb amputation;Link;male;mechanical properties;Metabolic Diseases;Methods;Microvascular Dysfunction;migration;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myofibroblast;nanosystems;non-healing wounds;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Outcome;Outcome Measure;Patients;Peptides;Perfusion;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Phase;phase 2 study;Phase I/II Clinical Trial;Physiological;Population;porcine model;pre-clinical;preclinical efficacy;Prediabetes syndrome;Predisposition;pressure;primary outcome;Privatization;product development;Production;protein aminoacid sequence;Public Health;public health relevance;Quality of life;re-epithelialization;Recurrence;Regimen;Research;Resources;revascularization;Rodent Model;Safety;scaffold;secondary outcome;Skin;Skin repair;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Source;Sterile coverings;Testing;Therapeutic;Time;Tissues;Translational Research;United States Food and Drug Administration;United States National Institutes of Health;Work;wound;wound care;wound closure;wound healing

PROJECT_TITLE: Novel peptide for enhancing diabetic wound healing


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Half of patients with heart failure (HF) have preserved pumping function of the heart (HFpEF). There is no FDA approved therapy for HFpEF, which may be due to the fact that there are many causes for HFpEF. The impact of our proposed studies is high as it will help us understand the different types of patients with HFpEF and allow us to personalize therapy.

PI_NAMEs: CHEN, HORNG H (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Acute;Aldosterone;Angiotensin Receptor;Annexin A1;Atrial Natriuretic Factor;atrial natriuretic factor receptor A;Attenuated;biomarker identification;Blood Vessels;Cardiac;Cardiorenal syndrome;Cardiovascular system;Categories;Chronic Kidney Failure;Classification;Clinic;Clinical;clinical phenotype;Cyclic GMP;Data;design;Diabetes Mellitus;Dyspnea;Edema;EFRAC;Exercise;Extracellular Matrix;FDA approved;first-in-human;Fluid overload;Funding;Half-Life;Heart failure;heart function;Heterogeneity;Homeostasis;Hour;Human;human study;Hypertension;improved;individualized medicine;inhibitor;Kidney;knowledge integration;Left Ventricular Ejection Fraction;Liquid substance;Lung;National Heart, Lung, and Blood Institute;Natriuresis;Natriuretic Peptides;Neprilysin;non-compliance;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Obesity;Particulate;Patients;Peripheral;personalized medicine;Phenotype;Physiological;Physiology;Plasma;pre-clinical;precision medicine;preservation;pressure;Pump;Receptor Inhibition;Renal function;Research Priority;Resistant Hypertension;response;Rest;Saline;Secondary to;Sodium;Stress;Stress Tests;Stretching;subcutaneous;Subgroup;Symptoms;System;Testing;valsartan;Ventricular;working group

PROJECT_TITLE: Human Cardiorenal Syndrome

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: The Indiana University (IU) Comprehensive Training Program in Clinical Pharmacology, currently in its 29th year, has a track record of excellence in training successful clinician scientists able to implement the science of clinical pharmacology and therapeutics in academic, pharmaceutical industry/biotechnology and drug regulatory agencies. We propose to continue this successful training program in a setting of a well-established Division of Clinical Pharmacology, multiple well-funded and experienced investigators to mentor trainees, a pipeline of highly qualified applicants, and outstanding institutional training environment and support. Our goal is to continue generating clinical scientists that can augment translation of new therapies into clinical practice and ensure safe and beneficial effects of medications.

PI_NAMEs: DESTA, ZERUESENAY  (contact);EADON, MICHAEL THOMAS

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Indiana University Comprehensive Training in Clinical Pharmacology


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Nutrition;Pediatric;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE This innovative study seeks to understand how the use of specific food parenting practices varies across time and context, and how various food parenting approaches impact children’s dietary intake over the long term. A longitudinal study with 240 parent-child pairs will be conducted with data collection via state-of-the-art measures, including EMA and interview-led 24-hour diet recalls, every 6 months for two years. The proposed study represents a significant and necessary next step to inform the development of clinic-based recommendations and public health interventions that account for- and are responsive to- daily challenges found to influence parent’s use of specific food parenting practices.

PI_NAMEs: LOTH, KATIE ANN (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Behavior;Child;Child Behavior;Child Rearing;Chronic Disease;Clinic;Data;Data Collection;design;Development;Diet;dietary;Dietary intake;Disease Outcome;Disparity;early childhood;early experience;Eating;Eating Behavior;Ecological momentary assessment;Ethnic Origin;evidence base;experience;Family;feeding;flexibility;follow-up;Food;Goals;Growth and Development function;handheld equipment;Health Food;Healthy Eating;Hour;improved;indexing;innovation;Intake;Intervention;Interview;Life;Location;Longitudinal Studies;Measures;Moods;Occupations;Outcome;parental influence;Parents;Pattern;Population;prevent;Prevention;public health intervention;Questionnaires;Race;Recommendation;Reporting;Research;response;Sampling;Schedule;shift work;Single Parent;socioeconomics;Stress;Structure;Surveys;therapy design;Time;Variant;Work

PROJECT_TITLE: Examination of the longitudinal impact of within- and between-day fluctuations in food parenting practices on child dietary intake

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE: Animal embryos undergo precisely timed cellular/nuclear divisions that rely on histone protein availability. While the embryo initially relies on histones donated from its mother, at some point, the embryo must begin manufacturing its own histones. I propose to examine the role of pioneering transcription factors in embryonic histone gene expression.

PI_NAMEs: O'HAREN, THOMAS E (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: 3-Dimensional;Animals;Architecture;Binding Sites;Biological Assay;Cell Cycle Arrest;Cell Differentiation process;Cell division;Chromatin;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;Collaborations;Data;defined contribution;Deposition;Development;Distant;DNA;Dosage Compensation (Genetics);Drosophila genus;Drosophila melanogaster;Embryo;Embryonic Development;Engineering;experimental study;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic Transcription;Genome;Goals;Histones;Human Development;insight;male;manufacture;Maps;Mediating;Methylation;Microscopy;Mothers;nuclear division;Nucleosomes;overexpression;Preparation;Process;Proteins;recruit;Regulation;Role;System;Techniques;Technology;Testing;Time;tool;transcription factor;Transgenes;Transgenic Organisms;Work;X Chromosome;zygote

PROJECT_TITLE: Developmental regulation of histone genes by pioneer factors and three-dimensional architecture

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: MH

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Despite the fundamental role that risk plays in evaluating choice options as well as the role sensitivity to risk plays in psychiatric illness, including anxiety disorders at one extreme and health risk behaviors like substance use at another other, an understanding of the neurobiology of risk remains elusive. Here, we take advantage of a new technology to directly measure serotonin, norepinephrine and dopamine on a sub-second basis to investigate the neurocomputational role of these neurotransmitters in risky choice.

PI_NAMEs: CASAS, BROOKS  (contact);MONTAGUE, P READ

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Anhedonia;Anxiety Disorders;arm;awake;Behavioral;Chemicals;Clinic;Computer software;Decision Making;Dopamine;Dorsal;Elasticity;Electrochemistry;Electrodes;Epilepsy;experience;Functional Magnetic Resonance Imaging;Goals;Health;Hospitals;Human;Implant;Implanted Electrodes;in vivo;Learning;Link;machine learning algorithm;Major Depressive Disorder;Measurement;Measures;Medial;Medical;Mental disorders;Methods;Monitor;neural;Neurobiology;Neuromodulator;Neurosciences;neurosurgery;Neurotransmitters;new technology;noradrenergic;Norepinephrine;Outcome;Participant;Pharmaceutical Preparations;Pharmacology Study;Phase;Play;Prefrontal Cortex;Process;Resistance;Resolution;response;Rewards;Risk;Risk Behaviors;Role;Serotonin;Signal Transduction;Specificity;substance use;temporal measurement;Testing;Update;Virginia;Work

PROJECT_TITLE: Direct sub-second measurement of neuromodulator signaling during risky decision-making

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: TOLEDO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: PUBLIC HEALTH RELEVANCE: Studies in this proposal aspire to demonstrate the role of cofilin in microglial activation and inflammation after hemorrhagic brain injury which is still a leading cause of death and disability in the US and worldwide. Our experiments will lead to a better understanding of the signaling of cofilin rods/aggregates after hemorrhagic brain injury and subsequent inflammation and cognitive impairments, thereby identifying novel therapeutic targets for treating this devastating disease.

PI_NAMEs: SHAH, ZAHOOR AHMAD (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: actin depolymerizing factor;Actin-Binding Protein;Actins;Address;aged;Alzheimer's Disease;American;analog;Animals;Area;Autologous;Autopsy;Behavioral;Binding;Biological Assay;Blood brain barrier dysfunction;Brain;Brain hemorrhage;Brain Injuries;calmodulin-dependent protein kinase II;Case Study;Cause of Death;Cell Death;Cells;Central Nervous System;Cerebral hemisphere hemorrhage;cofilin;cofilin 2;Corpus striatum structure;Crossbreeding;Cytoskeletal Proteins;Death Rate;disability;Disease;drug development;drug discovery;effective therapy;Enterobacteria phage P1 Cre recombinase;experimental study;F-Actin;Female;Filament;functional disability;Functional disorder;glial activation;Hematoma;Hemin;Human;Immune;Immunofluorescence Immunologic;Impaired cognition;improved;In Vitro;Inflammation;inhibitor;Injections;Injury;insight;Ischemic Stroke;Knock-out;Knockout Mice;Left;Lipopolysaccharides;male;Maps;Mediating;Mediator;Microfilaments;Microglia;migration;Modality;Modeling;Morbidity - disease rate;mortality;Motor disability;mouse model;Mus;Neurites;neurobehavioral;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neuronal Injury;Neurons;new therapeutic target;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Pathologic;Pathway interactions;Pattern;Phase;Pilot Projects;Play;post stroke cognitive impairment;Prevalence;Process;promoter;Protein Isoforms;PTGS2 gene;public health relevance;Publishing;Recovery;Risk;Rod;Role;Sex Differences;Signal Transduction;Site;Small Interfering RNA;spatiotemporal;Specimen;Stress;Stroke;stroke cognitive outcome;stroke therapy;Survivors;Synapses;Tail;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Therapeutic Studies;Time;TNF gene;translational potential;Veins;Whole Blood;Wild Type Mouse

PROJECT_TITLE: Cofilin Signaling in Hemorrhagic Stroke

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Eosinophilic esophagitis (EoE) is a chronic disease in which allergic inflammation and tissue damage eventually lead to scarring and fibrosis of the esophagus. This proposal seeks to elucidate the role of epithelial- derived transforming growth factor- (TGF) and lysyl oxidase (LOX) in tissue remodeling and fibrosis. Results from this study will lead to a more precise understanding of role of the esophageal epithelium in pathologic remodeling in the esophagus and will provide the basis for future work targeting the prevention and reversal of fibrosis in EoE.

PI_NAMEs: MUIR, AMANDA BROOKE (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: 3-Dimensional;Affect;Allergic inflammation;Antibodies;Award;Basal Cell Hyperplasia;Biological Assay;Biology;Caliber;career;Cell Proliferation;Cells;Cellular Assay;chromatin immunoprecipitation;Chronic;Chronic Disease;Cicatrix;Clinical;clinical application;Coculture Techniques;cohort;Collagen;Coupled;crosslink;cytokine;Data;Defect;Development;Diagnosis;disability;Disease;Down-Regulation;Drug Delivery Systems;Early Diagnosis;Enzymes;eosinophil;Eosinophilic Esophagitis;Eosinophilic Infiltrate;Epithelial Attachment;Epithelium;Esophageal mucous membrane;Esophageal Stenosis;Esophagus;Evaluation;Event;Feedback;Fibroblasts;Fibrosis;Flow Cytometry;Fluorescence-Activated Cell Sorting;food allergen;Future;Gene Expression Profiling;healing;Human;Immune;Impairment;improved;In Vitro;in vivo;Infiltration;Inflammation;inflammatory milieu;innovation;keratinocyte;Knowledge;Lamina Propria;Lead;mast cell;Mediating;Mediator;Modeling;Monitor;mouse model;Mucous Membrane;Mus;Myofibroblast;Organoids;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;pre-clinical;Prevention;Production;prognostic;prognostic value;Proliferating;Protein-Lysine 6-Oxidase;Proteins;Quality of life;Receptor Inhibition;reconstitution;Regulation;Reporting;Role;Signal Transduction;Source;Structure;Symptoms;System;targeted treatment;Therapeutic;Therapeutic Uses;Thick;three dimensional cell culture;Time;Tissues;Transcriptional Regulation;transdifferentiation;Transforming Growth Factors;United States National Institutes of Health;Work

PROJECT_TITLE: Lysyl oxidase induced esophageal remodeling in eosinophilic esophagitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-D(90)]


NIH_SPENDING_CATS: Clinical Research;Kidney Disease

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Testican-2 is made by a special cell in the kidney called podocytes. The purpose of this study is to understand how testican-2 protects podocytes from injury and whether testican-2 levels provide information about kidney health.

PI_NAMEs: WEN, DONGHAI  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Actins;Adhesions;Adriamycin PFS;Advisory Committees;Affinity;Albuminuria;Aorta;aptamer;Area;Attenuated;Binding;Biological Markers;Biological Process;Biology;Blood;Boston;career;career development;Cell surface;Cells;Chronic Kidney Failure;Circulation;Clinical Research;cohort;Creatinine;Cytoskeleton;Data;Dedications;Diabetic Nephropathy;Emerging Technologies;Enzyme-Linked Immunosorbent Assay;Etiology;experience;Extracellular Matrix;Extracellular Matrix Proteins;Fellowship;Focal and Segmental Glomerulosclerosis;Future;General Population;Genes;Genetic;Glomerular Filtration Rate;glomerulosclerosis;Glycoproteins;Goals;Grant;Health;Human;human subject;Immunoassay;Immunofluorescence Immunologic;In Vitro;in vivo;Individual;inhibitor;Injury;insight;Integrin alphaVbeta3;Interferometry;Interstitial Nephritis;ITGB3 gene;Kidney;kidney biopsy;Kidney Diseases;kidney metabolism;knock-down;Knowledge;Ligands;Manuscripts;Mass Spectrum Analysis;Measures;Mediating;Mentors;Mentorship;Microscopy;multidisciplinary;Mus;Nephrology;novel;novel therapeutic intervention;overexpression;Patients;Peptides;Physicians;Physiology;Play;podocyte;population based;Prognosis;prognostic;protective effect;protein protein interaction;Proteins;Proteomics;Public Speaking;Publications;Renal glomerular disease;Research;Research Personnel;Research Training;RGD (sequence);Role;Sampling;Science;Scientist;Serum;Signal Transduction;single-cell RNA sequencing;Site-Directed Mutagenesis;Structure;Structure of renal vein;Surface;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;Time;tissue biomarkers;Tissue Sample;Tissues;Training;training opportunity;translational approach;Vitronectin;Writing

PROJECT_TITLE: Biological function of testican-2 in podocyte health


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Activity

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The research described in this proposal aims to challenge traditional views of brain aging by using the rejuvenating effects of exercise-induced blood factors to obtain a mechanistic understanding of the molecular and cellular events required to counteract the effects of aging in the old brain. These studies will have significant translational potential, identifying molecular pathways that could be targeted for novel therapies to restore age-related cognitive dysfunction and potentially treat dementia-related neurodegenerative disorders such as Alzheimer's disease.

PI_NAMEs: VILLEDA, SAUL A (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Adherence;Adult;adult neurogenesis;Age;age effect;age related;age related decline;age related neurodegeneration;age-related disease;Aging;aging brain;aging hippocampus;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;animal old age;arm;Behavioral Paradigm;Bioluminescence;Blood;Brain;Cardiovascular system;Circulation;Cognition;cognitive benefits;cognitive function;cognitive process;conditioned fear;Confocal Microscopy;Data;Dementia;Elderly;Enzymes;Event;Exercise;Exposure to;fitness;frailty;Glycosylphosphatidylinositols;Health;hippocampal atrophy;Hippocampus;Human;Immunohistochemistry;Impaired cognition;improved;in vivo;Individual;insight;juvenile animal;Kinetics;Knowledge;Learning;Link;Liver;Mass Spectrum Analysis;Memory;Molecular;mouse model;Mus;Neurodegenerative Disorders;neurodegenerative phenotype;neurogenesis;new therapeutic target;old mice;overexpression;Parabiosis;Pathway interactions;Perception;phospholipase D1;Plasma;Population;Predisposition;Proteomics;Radial;regeneration function;regenerative;Regenerative capacity;Rejuvenation;Research;Role;Running;Site-Directed Mutagenesis;systemic intervention;Testing;theories;Therapeutic;Therapeutic Effect;translational potential;water maze

PROJECT_TITLE: Role of exercise-induced blood factors in rejuvenating the aged brain


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Rotavirus (RV) infections kill an estimated 130,000-215,000 young children globally in spite of the recent introduction of vaccines, highlighting the importance for continued study of this pathogen. Our proposed studies are designed to understand how RVs take advantage of key host cellular pathways involved in the accumulation of fat (lipid) and cellular membranes to form specialized sites in the infected cell critical for virus replication. We expect the knowledge gained from our studies will help (1) understand how RVs and many other viruses cause disease, (2) explain why RV infections in children become life-threatening, and (3) lead to new treatment and antiviral therapies.

PI_NAMEs: CRAWFORD, SUE ELLEN;ESTES, MARY KOLB (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: absorption;Address;Affect;Anti-viral Therapy;Autophagocytosis;Bacterial Infections;BCAR3 gene;Biogenesis;Biology;Calcium;Cells;Cellular Membrane;Child;Cholesterol Esters;Chylomicrons;Cytoplasm;Cytoplasmic Organelle;design;Diabetes Mellitus;diacylglycerol O-acyltransferase;Diarrhea;Disease;Endoplasmic Reticulum;enteric infection;Enterocytes;Enzymes;experimental study;Fatty acid glycerol esters;Gastroenteritis;Goals;Health;Heart Diseases;Homeostasis;Human;human disease;human pathogen;Hypertriglyceridemia;Immune response;immunoregulation;Infectious Agent;Inflammatory Response;insight;interest;Intestines;Intracellular Membranes;Knowledge;Lead;Life;Lipids;Membrane;Metabolic Pathway;Metabolism;model organism;Modeling;Molecular;monolayer;multicatalytic endopeptidase complex;Nonstructural Protein;novel;Obesity;Organelles;pathogen;Pathogenesis;Pathway interactions;perilipin;Phospholipids;Phosphorylation;Play;Protein Isoforms;Protein Kinase;Proteins;Regulation;Research;Role;Rotavirus;Rotavirus Infections;Signal Pathway;Signal Transduction;Site;Small Intestines;Tissues;trafficking;Triglycerides;Vaccines;Viral;Viral Proteins;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Regulation of Rotavirus Replication

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ADMINISTERING_IC: CA

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The American Cancer Society estimates that in 2019 around 74,000 people will be diagnosed with non-Hodgkin Lymphoma (NHL). The majority of these tumors arise from B cells (B-NHL) at the germinal center stage of differentiation. Using mouse models of B-NHL that recapitulate the human disease, we will determine the function and potential targeting of Coactivator-Associated Arginine Methyltransferase 1 (CARM1) in NHBCL.

PI_NAMEs: GREEN, MICHAEL RICHARD;SANTOS, MARGARIDA  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acetyltransferase;Affect;Alleles;American Cancer Society;Animals;Arginine;arginine methyltransferase;attenuation;B-Cell Activation;B-Cell Development;B-Cell Lymphomas;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;Behavior;Biological Assay;Biological Availability;Bromodomain;cell growth;Cell Line;Cell Survival;cell type;Cellular biology;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical Research;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;coactivator-associated arginine methyltransferase 1;Complex;conditional knockout;CREBBP gene;CRISPR screen;CRISPR/Cas technology;Critical Pathways;Data;Development;Diagnosis;Disease;EP300 gene;Epigenetic Process;epigenetic profiling;epigenetic therapy;Etiology;Exhibits;Follicular Lymphoma;Frequencies;Future;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Goals;Growth;histone acetyltransferase;Human;human disease;Immunization;Immunotherapy;Indolent;inhibitor;innovation;insight;Knock-out;knockout animal;Knockout Mice;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;Late Effects;Lesion;Lymphoma;Lymphoma cell;Lymphomagenesis;Malignant neoplasm of lung;Malignant Neoplasms;malignant phenotype;Mediating;Methylation;Molecular;Molecular Biology;mouse model;Mus;mutant;Mutate;Mutation;Neoplasms;Neoplastic Cell Transformation;next generation sequencing;Non-Hodgkin's Lymphoma;novel;Oral;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Pattern;Persons;Phenotype;Play;premalignant;Progressive Disease;Protein-Arginine N-Methyltransferase;Publishing;Recurrent disease;Refractory;Regulation;Residual state;response;Role;side effect;Small Interfering RNA;small molecule inhibitor;Somatic Mutation;Spleen;Structure of germinal center of lymph node;targeted treatment;Testing;Therapeutic;therapeutic target;Transplantation;tumor;Work;Xenograft Model

PROJECT_TITLE: Roles of Coactivator-Associated Arginine Methyltransferase 1 in B cell activation and lymphomagenesis

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The goal of this project is to develop a comprehensive learning-based causal inference framework to generate high-throughput drug repurposing hypotheses for Alzheimer’s' disease and related dementias (AD/ADRD) from real-world data and biomedical knowledge bases. The generated drug repurposing hypotheses will be validated with diverse data sources and approaches including (1) using multi-omics data based on the network medicine approach, and (2) using the trial emulation approach and with i) high-quality cohorts’ data from the National Alzheimer's Coordinating Center (NACC), and ii) a prospective RWD-based cohort. The developed algorithms and software tools will be made publicly available and widely disseminated in the AD/ADRD research communities.

PI_NAMEs: BIAN, JIANG ;WANG, FEI  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Acceleration;Affect;age related neurodegeneration;Algorithmic Software;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;base;billing data;Bioinformatics;Biological;Biology;Cause of Death;Characteristics;Clinical Medicine;Clinical Research;cohort;Cohort Studies;Collection;Communities;Complex;computable phenotypes;Computer software;computerized tools;cost;cost effective;Data;Data Science;Data Sources;deep learning;Development;disease heterogeneity;diverse data;Dose;drug candidate;drug development;drug quality;drug repurposing;Electronic Health Record;Evaluation;Failure;Formulation;Functional disorder;Future;Generations;Goals;heterogenous data;high risk;improved;in silico;Investments;Knowledge;knowledge graph;Learning;Machine Learning;machine learning framework;Malignant Neoplasms;manufacture;Medical Genetics;Medicine;Methodology;Methods;Molecular;Multiomic Data;Natural Language Processing;novel;novel therapeutic intervention;open source;Outcome;Pathogenicity;patient oriented;Patients;Pharmaceutical Preparations;phenotyping algorithm;pragmatic trial;Prevention strategy;Program Development;Proliferating;prospective;Prospective cohort;Reporting;Research;Safety;Sampling;Severities;Signal Transduction;Software Tools;Source;Standardization;study population;success;Techniques;tool;translational impact;United States;Update;Validation

PROJECT_TITLE: Computational Drug Repurposing for AD/ADRD with Integrative Analysis of Real World Data and Biomedical Knowledge


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Pain Research;Physical Injury - Accidents and Adverse Effects;Prevention;Wound Healing and Care

ORG_CITY: CHAPEL HILL

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Chronic pain is a common, morbid sequela following burn injury. Currently, there are no therapies to prevent chronic pain development after burn injury; therefore, the goal of this research is to provide evidence on the effectiveness and corresponding immune mechanisms of vitamin D to prevent chronic pain following major thermal burn injury. This work has the potential to improve pain outcomes, understand important mechanisms through which vitamin D reduces pain, and provide new mechanistic insights into the transition from acute to chronic pain following burn injury.

PI_NAMEs: MAUCK, MATTHEW CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: Acute;adaptive immunity;Affect;Algorithms;Anti-Inflammatory Agents;Area;arm;Biological;Biology;biopsychosocial factor;Blood specimen;Burn injury;care seeking;career;Cell Culture Techniques;Cells;Chronic;chronic pain;Clinical;Clinical Trials;Communities;Confidence Intervals;cost;Cytometry;Data;depressive symptoms;Development;dimensional analysis;Disease;Dropout;Effectiveness;Elasticity;Enrollment;Equilibrium;experience;Foundations;Funding;Goals;Growth;high dimensionality;high risk;Hospitalization;Immune;Immunologics;improved;Individual;Inflammatory;insight;Institution;Intervention;Intervention Trial;Investments;Learning;Measurement;Measures;Mediating;Mediation;Mentored Clinical Scientist Development Program;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modeling;monocyte;National Center for Complementary and Integrative Health;Natural Immunity;Natural Products;neuroprotection;non-opioid analgesic;Operative Surgical Procedures;Outcome;Pain;pain chronification;pain outcome;pain reduction;Participant;Pathogenesis;Patients;Phenotype;Plasma;Population;prevent;Property;Protocols documentation;Psychosocial Factor;Psychosocial Influences;Randomized;Randomized, Controlled Trials;recruit;Regulation;Regulatory T-Lymphocyte;Research;Research Personnel;Safety;Science;screening;secondary analysis;Signal Transduction;Site;skills;Skin;Skin graft;sociodemographic factors;Statistical Methods;success;Survivors;Testing;Therapeutic;Therapeutic Effect;Tissue Grafts;TLR4 gene;Training;treatment effect;United States National Institutes of Health;Vitamin D;Work;wound;wound healing

PROJECT_TITLE: Immune mechanisms of Vitamin D in a randomized controlled trial to reduce chronic pain after burn.


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Heart Disease;Liver Disease;Prevention

ORG_CITY: MINEOLA

ORG_NAME: NEW YORK UNIVERSITY D/B/A NYU LONG ISLAND SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Cardiovascular disease is one of the risk factors for nonalcoholic fatty liver diseases (NAFLD), an emerging metabolic disease in the US population. The proposed research will lead to many discoveries that will significantly improve the health of US citizens and others suffering from nonalcoholic fatty liver disease by revealing new concepts and ideas that can be used to develop therapies for the prevention and treatment of atherosclerosis. Thus, the proposed research is relevant to NIH's mission that pertains to developing new approaches and fundamental knowledge that will help to reduce the burdens of human disability.

PI_NAMEs: MIAO, QING  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Acetylation;Acetyltransferase;Affect;Atherosclerosis;Cardiovascular Diseases;cardiovascular disorder risk;Cause of Death;Cholesterol;Cholesterol Homeostasis;CRISPR/Cas technology;cytokine;Data;Deacetylase;Development;disability;Down-Regulation;Fatty Liver;Gene set enrichment analysis;Genes;Genetic Transcription;Health;Hepatic;Hepatocyte;Heterodimerization;High Fat Diet;Histone Deacetylase;Human;hypercholesterolemia;Impairment;improved;in vivo;Inflammatory;Knockout Mice;Knowledge;LDL Cholesterol Lipoproteins;Lead;lipid biosynthesis;Lipids;Liver;Liver diseases;Low Density Lipoprotein Receptor;LXRalpha protein;Mediating;Metabolic Diseases;Mission;Molecular;Monoclonal Antibodies;mouse model;Mus;mutant;non-alcoholic fatty liver;non-alcoholic fatty liver disease;novel;novel strategies;Nuclear Receptors;Nuclear Translocation;obesity prevention;overexpression;Pathogenesis;Pathway interactions;Patients;Plasma;Population;Post-Translational Protein Processing;PPAR alpha;preservation;prevent;Prevention therapy;Production;Proprotein Convertases;Repression;Research;resilience factor;Risk Factors;Role;RXRA gene;Signal Pathway;Signal Transduction;Subtilisins;success;Testing;therapy development;TNF gene;transcriptome sequencing;United States;United States National Institutes of Health;Up-Regulation

PROJECT_TITLE: Role of Retinoid X Receptor Alpha in regulating PCSK9 transcription in the liver

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative This project uses preclinical mouse models to investigate how inflammation during the saccular stage of lung development alters the arrangement of elastic fibers in newborn lungs and leads to abnormal lung structure and function throughout life. Successful completion of these studies may allow us to identify therapeutic strategies that will benefit both neonates and adults with chronic lung disease.

PI_NAMEs: BENJAMIN, JOHN  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Acceleration;Adult;Age Months;age related decline;airway epithelium;Alveolar;Area;Birth;Bronchopulmonary Dysplasia;Cause of Death;Cells;Childhood;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;cigarette smoke;clinically relevant;Complication;Data;design;Development;Disease;disease phenotype;Distal;Down-Regulation;Doxycycline;Elastic Fiber;Elastin;emerging adult;empowerment;Epidermal Growth Factor Receptor;Epithelial Cells;Epithelium;Escherichia coli;Exposure to;exposure to cigarette smoke;Failure;FBLN5 gene;Fibroblasts;Future;genetic approach;Growth;Hyperoxia;Impairment;In Situ Hybridization;infancy;Infant;Inflammation;Inflammatory;Investigation;Leukocyte Elastase;Life;life span;Lipopolysaccharides;Long-Term Effects;Lung;lung development;Lung Diseases;Mediating;Mesenchymal;Mesenchyme;Modeling;mouse model;Mus;Neonatal;Neonatal lung;neonatal lung disease;neonate;neutrophil;Neutrophil Activation;novel;Patients;pharmacologic;Phenotype;Population;pre-clinical;Predisposition;premature;Premature Infant;prevent;Pulmonary Emphysema;pulmonary function;Pulmonary Inflammation;Receptor Signaling;Regulation;respiratory morbidity;Risk;RNA;Role;scaffold;Signal Pathway;single-cell RNA sequencing;Slice;stem;Stimulus;Structure;Survivors;Testing;Therapeutic;Transgenic Mice;Transgenic Model

PROJECT_TITLE: Developmental Origins of COPD

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Cognitive symptoms in patients with Parkinson’s disease cause morbidity and mortality and have few effective treatments. This proposal explores the fundamental mechanisms of dopamine and cognition in rodent models with the hope of generating new treatments for cognitive dysfunction in Parkinson’s disease.

PI_NAMEs: NARAYANAN, NANDAKUMAR  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;Alzheimer's disease related dementia;Area;Attention;Attenuated;Basic Science;Behavior;Behavioral;Biological Markers;cell type;Cessation of life;Cognition;Cognitive;cognitive function;cognitive impairment in Parkinson's;cognitive performance;cognitive process;Data;Dementia;Dementia with Lewy Bodies;Disease;Dopamine;dopaminergic neuron;effective therapy;Employment;Executive Dysfunction;executive function;Fiber;flexibility;Goals;Hallucinations;Human;Impaired cognition;Impairment;improved;Internal Ribosome Entry Site;Knowledge;Methods;Midbrain structure;millisecond;Morbidity - disease rate;mortality;Motivation;motor symptom;mouse model;Mus;Neurobehavioral Manifestations;Neurons;novel;novel therapeutics;Nucleus Accumbens;Nursing Homes;optogenetics;Parkinson Disease;Participant;Patients;Performance;Photometry;Prefrontal Cortex;Psychoses;Publishing;reduce symptoms;Research;Resolution;Rewards;RNA Interference;Rodent;Rodent Model;Short-Term Memory;societal costs;Specificity;Substantia nigra structure;Symptoms;temporal measurement;Testing;Time;time interval;Training;Transgenic Mice;Tyrosine 3-Monooxygenase;Ventral Tegmental Area;Work

PROJECT_TITLE: VTA dopamine neurons and cognitive symptoms of Parkinson’s disease

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Sleep Research

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: The locus coeruleus and the entorhinal cortex region of the brain are among the first to be affected in Alzheimer’s disease, causing sleep problems and cognitive dysfunction. Using multi-region recording probes we will evaluate their function to determine which one of them is more vulnerable to tau and aβ pathology. We will test if by using optogenetic approach the neurons in these regions can be rescued and cognitive deficits be reversed.

PI_NAMEs: HUSSAINI, S. ABID  (contact)

PROJECT_TERMS: 20 year old;Adult;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Amyloid beta-Protein;Animal Testing;Animals;Arousal;Behavior;behavior measurement;Behavioral;Biological Markers;Brain;Brain region;Brain Stem;Cognitive;cognitive ability;Cognitive deficits;cognitive testing;computational neuroscience;Computing Methodologies;Confusion;Data;Disorientation;Electrophysiology (science);entorhinal cortex;Environment;Evaluation;Functional disorder;Halorhodopsins;Head;Hippocampus;Home;Human;Hyperactivity;Immunohistochemistry;Impaired cognition;Impairment;Knock-in Mouse;Learning;Life;Location;locus ceruleus structure;machine learning algorithm;Measures;Medial;Memory;memory consolidation;Memory impairment;mouse model;Mus;neural;Neurobehavioral Manifestations;neuron loss;Neuronal Dysfunction;Neurons;Neurosciences;non rapid eye movement;optogenetics;Pathologic;Pathology;Performance;Physiological;Positioning Attribute;predictive test;Property;rapid eye movement;Role;Shapes;Silicon;Sleep;Sleep Disorders;Sleep disturbances;sleep regulation;Sleep Stages;Slow-Wave Sleep;spatial memory;Symptoms;targeted treatment;tau aggregation;tau Proteins;Tauopathies;Techniques;Testing;tool;virtual environment;virtual reality;virtual reality environment;way finding;Wild Type Mouse;Work

PROJECT_TITLE: Electrophysiological Evaluation of Brain Regions Vulnerable to Alzheimers Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Social Determinants of Health

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The proposed NCI R01 will refine and test a digital solution, called the eNav Toolkit, designed to improve colorectal cancer (CRC) screening uptake among patients treated at federally qualified health centers (FQHCs). If proven efficacious, the eNav Toolkit can revolutionize the standard care for CRC prevention in FQHCs with the ultimate goal of increasing CRC screening rates among socioeconomically disadvantaged and underserved patient populations.

PI_NAMEs: MILLER, SARAH J (contact)

PROGRAM_OFFICER_NAME: RANDHAWA, GURVANEET

PROJECT_TERMS: 2019-nCoV;Adherence;Adult;Appointment;barrier to care;Belief;Cancer Etiology;Caring;Cellular Phone;Cessation of life;Colonoscopy;Colorectal Cancer;colorectal cancer prevention;colorectal cancer screening;Communities;Complex;Computers;cost;COVID-19 pandemic;Cues;Data;Decision Making;design;Diagnosis;digital;digital health;digital solutions;Disparity population;Economically Deprived Population;Economics;Education;Effectiveness;efficacy evaluation;efficacy testing;Electronic Health Record;Eligibility Determination;Enrollment;Equation;ethnic minority;Ethnic Origin;Ethnic Population;experience;Federally Qualified Health Center;Feedback;field study;follow-up;Funding;Goals;Guidelines;Health;health belief;Health Services Accessibility;Healthcare;Healthcare Systems;improved;Incidence;Individual;Instruction;Intervention;Malignant Neoplasms;Mediation;Mediator;Modeling;mortality;mortality disparity;Motivation;motivational enhancement therapy;Neighborhood Health Center;Participant;patient navigation;patient oriented;patient population;Patients;Persons;Poverty;Predisposition;Preparation;Preventive Medicine;primary outcome;Procedures;Public Domains;Public Health;Questionnaires;Race;racial minority;racial population;Randomized;randomized, clinical trials;Recommendation;Research;Resource-limited setting;Resources;Risk;screening;screening guidelines;secondary outcome;Self Efficacy;Site;socioeconomic disadvantage;Socioeconomic Status;socioeconomics;standard care;Tablets;Test Result;Testing;Text;Time;treatment as usual;Underserved Population;Unemployment;Uninsured;United States;United States Health Resources and Services Administration;uptake;web app

PROJECT_TITLE: Developing and Testing a Digital Toolkit to Improve Colorectal Cancer Screening Rates in Federally Qualified Health Centers

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases

ORG_CITY: DETROIT

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Bacterial endophthalmitis remains a significant cause of visual loss in patients undergoing eye surgeries. As the aging population grow worldwide, the demand for cataract and other ocular surgeries increases as well, and so too will the incidence of endophthalmitis. In this study, we aim to investigate the role of NAD+ in protecting the eye during infection and provide the rationale to consider NAD+ boosting supplements as an adjunct therapy to treat bacterial endophthalmitis.

PI_NAMEs: KUMAR, ASHOK  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: aging population;Antibiotics;bacterial endophthalmitis;Bacterial Infections;Bioenergetics;Biosensor;Blindness;Cataract;Cell Death;cell type;Cells;Citric Acid Cycle;Communicable Diseases;Complement;Complication;Consumption;Cultured Cells;Data;Disease;Endophthalmitis;Energy Metabolism;Enzymes;Exhibits;Eye;Eye Infections;Funding;gene therapy;Generations;Genes;Genetic;Global Change;Goals;Homeostasis;Impairment;In Vitro;Incidence;Individual;Infection;Inflammation;Inflammatory Response;insight;Intervention;intravitreal injection;Knockout Mice;Link;Measurement;Mediating;Metabolic;Metabolism;metabolomics;Mitochondria;mouse genetics;Mus;NAD+ Nucleosidase;Natural Immunity;Niacinamide;Nicotinamide adenine dinucleotide;Nicotinamide Mononucleotide;nicotinamide phosphoribosyltransferase;Nicotinamide-Nucleotide Adenylyltransferase;Nicotinic Acids;Operative Surgical Procedures;Ophthalmologic Surgical Procedures;overexpression;Oxidation-Reduction;pathogen;Pathogenesis;Pathway interactions;Patients;Penetrating Eye Injuries;pharmacologic;prevent;Protein Kinase Interaction;Receptor Activation;Receptor-Interacting Protein;Research;restoration;Retina;Role;Severities;Signal Transduction;Sirtuins;Staphylococcus aureus;Staphylococcus aureus infection;Supplementation;Testing;Therapeutic;therapeutic target;Tissues;tool;transcriptomics;treatment strategy;Vision

PROJECT_TITLE: Targeting NAD metabolism to ameliorate bacterial endophthalmitis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Emerging adulthood is a high-risk time for type 1 diabetes (T1D). We test the efficacy of a newly developed intervention (FAMS-T1D, modifying FAMS developed for type 2 diabetes) to examine how it improves self- regulation and social support and thereby T1D management.

PI_NAMEs: BERG, CYNTHIA A (contact);MAYBERRY, LINDSAY S.;WIEBE, DEBORAH J

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Address;Adolescence;Adult;Age;American;Behavior;Blood Glucose;blood glucose regulation;Characteristics;Childhood;Cognition;college;comparison intervention;Continuous Glucose Monitor;Data;Deterioration;diabetes distress;diabetes management;Diabetes Mellitus;Diet;Disclosure;effective intervention;effectiveness evaluation;efficacy testing;emerging adult;emerging adulthood;Enrollment;ethnic diversity;Ethnic Origin;experience;Failure;Family;forgetting;Friends;Goals;Grain;high risk;improved;Individual;Informal Social Control;innovation;Insulin-Dependent Diabetes Mellitus;Intervention;intervention effect;Knowledge;Life;Measures;Mediating;Mediator;meetings;Non-Insulin-Dependent Diabetes Mellitus;Outcome;parental involvement;Parents;Participant;Patient-Focused Outcomes;Patients;Persons;Pilot Projects;post intervention;primary outcome;Public Health;racial diversity;Randomized, Controlled Trials;Recommendation;recruit;Regulation;Reporting;Research;Resources;Risk;Sampling;Schools;secondary outcome;Self Care;Self Efficacy;Self Management;Site;skills;social;Social Change;social relationships;Social support;Telephone;telephone coaching;Text Messaging;Theoretical model;theories;Time;treatment as usual;Treatment Efficacy;Work

PROJECT_TITLE: Improving Self-Regulation and Social Support for Type 1 Diabetes During Emerging Adulthood

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-C(90)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Heart disease during pregnancy with no previous history of cardiovascular disease is uncommon; however, its prevalence has increased over the past decades as more women delay their pregnancy. Heart disease during pregnancy bears a worse prognosis than in non-pregnant women for unclear reasons. Here, we propose to study what makes the heart in late pregnancy be more vulnerable to heart disease and to find potential therapeutic targets for the treatment of pregnant women who are at higher risk of cardiovascular disease.

PI_NAMEs: ARYAN, LAILA  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: 3-Dimensional;advanced maternal age;Age;age group;age related;Apoptosis;Biological Assay;Cardiac;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cessation of life;Chronic;circulating microRNA;Computer software;Data;Diabetes Mellitus;Diagnostic;Disease;early detection biomarkers;Event;Female;Gene Expression;Heart;Heart Diseases;high risk;High Risk Woman;Hypertension;Hypoxia;In Vitro;in vivo;Infarction;Inflammation;inflammatory marker;Injury;innovation;knock-down;Late pregnancy;Lead;Life;Life Style;Luciferases;Maternal Age;Mediating;Micro Array Data;Microarray Analysis;MicroRNAs;Mitochondria;Modality;Modeling;Molecular;Mothers;Mus;myocardial infarct sizing;Myocardial Infarction;Myocardial Reperfusion Injury;novel;Obesity;overexpression;Oxidative Stress;Pathologic Processes;Patients;peripartum cardiomyopathy;Physiological Processes;Plasma;predictive tools;Predisposition;Pregnancy;pregnant;Pregnant Women;prenatal;Prevalence;Production;Prognosis;prognostic;protein expression;Rattus;Reactive Oxygen Species;Recording of previous events;Regulation;Regulator Genes;Relative Risks;Reperfusion Injury;Reperfusion Therapy;Reporting;reproductive;Rodent;Role;Serum;Smoking;Societies;STAT3 gene;Stimulus;Testing;Therapeutic;therapeutic target;Third Pregnancy Trimester;translational potential;Western Blotting;Woman

PROJECT_TITLE: Role of microRNA-98 in Myocardial Ischemia Reperfusion Injury in Late Pregnancy


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Estrogen;Fentanyl Misuse and Addiction;Genetics;Opioid Misuse and Addiction;Opioids;Substance Misuse;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: PROJECT NARRATIVE Opioid use disorder (OUD) is a major epidemic in the United States, and despite a severe impact on women, very little information is known regarding mechanisms underlying OUD in females or sex-specific differences in the development, expression, and molecular mechanisms of OUD. Thus, the goal of this F30 application is to fill these research gaps using a novel rat model of OUD with fentanyl, and in doing so, provide foundational information on sex differences in OUD that can be used to refine the use of already approved treatments for OUD in women versus men as well as guide the development of new sex-specific treatments for OUD. These studies will also address gaps in my training and facilitate my development as an independent physician scientist specializing in substance use disorder.

PI_NAMEs: TOWERS, ELEANOR  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Address;Animal Model;Animals;Attenuated;Automobile Driving;Behavioral;biological sex;Buprenorphine;Chronic;cohort;craving;Cues;Data;Development;differential expression;Disease;Dorsal;drug craving;drug relapse;Drug usage;Epidemic;Estradiol;experience;FDA approved;Female;Fentanyl;fentanyl seeking;fentanyl self-administration;fentanyl use;Gene Expression Profile;Genes;Genetic Transcription;Goals;Health;Hormonal;Hormones;Human;human model;Intravenous;male;Medial;Medical;medication for opioid use disorder;men;Modeling;Molecular;Motivation;Neurobiology;novel;Opiate Addiction;Opioid;opioid use disorder;Oral Contraceptives;Ovarian hormone;Ovariectomy;Pharmaceutical Preparations;Phenotype;Physicians;Positioning Attribute;preclinical study;Prefrontal Cortex;prevent;Prevention strategy;Procedures;Progesterone;psychologic;Punishment;Rattus;Relapse;Reporting;Research;Role;Schedule;Scientist;Self Administration;Severities;sex;Sex Differences;Stimulant;Substance Use Disorder;Testing;Time;Tissues;Training;transcriptome;transcriptome sequencing;treatment strategy;United States;Withdrawal;Woman;women versus men

PROJECT_TITLE: Sex Differences in a Rat Model of Opioid Use disorder


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative CNS barrier breakdown occurs in a wide variety of CNS diseases, from acute brain injury or infection to neurodegenerative disorders like Alzheimer’s Disease, disrupting ion balance needed for neuronal function and exposing the cerebrospinal (CSF) fluid and brain tissue to blood contents and circulating, peripheral immune cells that upon entry can irreparably damage the CNS. As a result, barrier breakdown can have long lasting or permanent motor, behavioral and cognitive deficits in patients. This proposal focuses on an understudied and poorly understood part of the CNS barrier system, the arachnoid barrier in the meninges; our studies of this barrier will provide key insight into its development, function in regulating normal ionic, protein and cellular content of the CSF and its vulnerability in diseases like bacterial meningitis.

PI_NAMEs: SIEGENTHALER, JULIE  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Acute Brain Injuries;Adult;Age;age related;Alzheimer's Disease;Animal Model;Arachnoid mater;Award;Bacterial Meningitis;Behavioral;beta catenin;Biological Assay;Birth;Blood;Blood - brain barrier anatomy;blood cerebrospinal fluid barrier;Blood Vessels;Brain;brain tissue;Carrier Proteins;cell type;Cells;Central Nervous System;Central Nervous System Diseases;central nervous system injury;Cerebrospinal Fluid;Choroid Plexus Epithelium;Clinical;Cognitive deficits;Collaborations;Data;design;Development;Disease;Down-Regulation;Drug Delivery Systems;Dura Mater;E-Cadherin;Embryo;Endothelium;Epithelium;Equilibrium;experimental study;fetal;Functional disorder;Future;Genetic Transcription;Growth;Hand;Health;Homeostasis;Immune;immune activation;Impairment;in vivo;Infection;inhibitor;insight;Intercellular Junctions;interest;Ions;Knowledge;Life;Location;Measures;Meningeal;Meninges;Meningitis;Mesenchymal;Metabolic;Methods;Modeling;Mole the mammal;Molecular;Motor;mouse model;Movement;Multiple Sclerosis;Mus;Mutant Strains Mice;Neonatal;neonate;nervous system development;Neurodegenerative Disorders;neuroinflammation;Neurons;neuropathology;Pathology;Patients;Perinatal;Peripheral;Permeability;Pharmaceutical Preparations;postnatal;postnatal development;Predisposition;prenatal;Property;protein expression;Proteins;Regulation;repaired;Reporting;response;Role;segregation;Signal Transduction;single-cell RNA sequencing;Site;Specific qualifier value;Spinal Cord;Streptococcal Infections;Streptococcus Group B;Structure;Structure of choroid plexus;Subarachnoid Space;System;Testing;Therapeutic;Tight Junctions;Time;tool;Tracer;Vascular System;Visualization;Work

PROJECT_TITLE: Development and function of the meninges arachnoid barrier


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Genetics;Human Genome;Patient Safety;Precision Medicine

PHR: Type 2 diabetes can be treated with various glucose-lowering medications, but guidance to match each drug to the pathophysiology affecting an individual patient is lacking. We plan to leverage the DNA samples and data of consented 4,730 participants in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study to conduct a genome-wide association study, in which we will identify genetic determinants of drug response, of glycemic traits relevant to specific modes of action, of side effects, and of diabetic complications. This pharmacogenomic resource will also enable the testing of polygenic scores constructed from established genetic variants for association with drug response endpoints, as a way to advance precision medicine in diabetes.

PI_NAMEs: FLOREZ, JOSE CARLOS (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Address;Adverse effects;Affect;Agonist;basal insulin;Beta Cell;blood glucose regulation;Candidate Disease Gene;Cell Physiology;Clinical;clinical decision-making;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Design;cohort;comparative effectiveness;comparative effectiveness trial;Complex;Complications of Diabetes Mellitus;Consent;Continuous Glucose Monitor;cost;Data;Decision Making;Diabetes Mellitus;diabetes mellitus therapy;Disease;DNA;drug intolerance;effectiveness evaluation;Functional disorder;Genes;Genetic;genetic analysis;Genetic Determinism;Genetic Markers;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic locus;Genomic Segment;genomic variation;GLP-I receptor;Glucose;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Human;Incidence;Individual;Individual Differences;individual patient;individualized medicine;inhibitor;insulin sensitivity;Knowledge;Medical;Metabolic;Metformin;Molecular Target;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;OGTT;Participant;Pathogenicity;Patients;Periodicals;personalized medicine;Pharmaceutical Preparations;Pharmacogenetics;Pharmacogenomics;pharmacologic;Pharmacotherapy;Phenotype;Physiological;Physiology;precision medicine;predicting response;predictive tools;Randomized;Resources;response;Risk;Sampling;side effect;Sulfonylurea Compounds;Testing;Therapeutic Agents;trait;Treatment Efficacy;treatment response;trial comparing;Validation;Variant;whole genome

PROJECT_TITLE: Pharmacogenetic discovery in the GRADE comparative effectiveness type 2 diabetes clinical trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(07)]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Social Determinants of Health;Teenage Pregnancy

ORG_CITY: DURHAM

ORG_NAME: INNOVATION RESEARCH AND TRAINING, INC.

PHR: Project Narrative Media literacy education (MLE) is an effective approach to sexual and relationship health promotion for young adult community college students, but little is understood regarding the incremental impact 0f MLE above traditional sexual health programming, the mechanisms underlying MLE’s impact on health outcomes, or the long-term impact of MLE on sexual and relationship health behaviors. The purpose of this project is to conduct a three-arm randomized control trial with long-term follow-up to isolate the effects of MLE on health outcomes, examine potential mediators of MLE’s health effects, and evaluate the immediate and long-term impact of a MLE sexual and relationship health promotion program for community college students, Media Aware Sexual Health for Young Adults (MASH-YA). This project has the potential to advance theory and inform the development of future MLE health promotion programs, as well as to shift the paradigm towards community colleges implementing evidence-based sexual and relationship health programming.

PI_NAMEs: SCULL, TRACY MARIE (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: active control;active control group;Adolescent;Adolescent and Young Adult;Adoption;Age;arm;Awareness;Behavior;Behavioral;Belief;Cognition;college;community college;Community Health;condom use rate;condoms;Consumption;Control Groups;Critical Thinking;dating violence;design;Development;Distal;Education;Educational Intervention;Effectiveness;Evaluation;evidence base;experience;Feedback;Future;Goals;group intervention;Health;Health behavior;Health education;Health Promotion;Health Promotion and Education;Health Resources;Health Services;high risk sexual behavior;Human Resources;implementation science;improved;information gathering;Interview;Latex;Left;literacy;Long-Term Effects;Longterm Follow-up;media use;Mediator;novel;novel strategies;Online Systems;Outcome;peer;Population;Populations at Risk;prevent;Prevention education;Prevention program;programs;Questionnaires;Randomized;Randomized, Controlled Trials;Reduce health disparities;Research;Research Design;sex;Sex Behavior;sexual assault;Sexual Health;Sexual Partners;skills;Structure;Students;Testing;theories;Time;Underserved Population;underserved students;unintended pregnancy;university student;Unsafe Sex;willingness;young adult

PROJECT_TITLE: Mechanisms of Media Literacy Education for Promoting Relationship Health in Older Adolescents

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Organ Transplantation;Transplantation

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative The donor lung supply is inadequate to meet the ever-increasing need of patients awaiting transplant. Compounding this problem, the US lung transplant system does not consider all known donor and patient information available at time of an organ offer, missing the opportunity to maximize best use of organs and survival gained from each transplant. This research will contribute to the development of a system that will use all known data at the time of an organ offer to find the best donor and patient match improving utilization of available organs and maximizing transplant patient survival.

PI_NAMEs: LEHR, CARLI  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Accounting;Affect;Algorithms;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence method;Bioethics;career;career development;Characteristics;Clinical;Complex;dalton;Data;Development;evidence base;functional status;Goals;Healthcare;Heart;improved;individual patient;innovation;Interdisciplinary Study;Intervention;Intuition;K-Series Research Career Programs;Kidney Transplantation;Leadership;Learning;Lung;Lung Diseases;Lung Transplantation;Machine Learning;machine learning model;Medical;Mentors;Methodology;Modeling;Modernization;Modification;mortality;Organ;organ allocation;Organ Donor;Outcome;Outcomes Research;Patient-Focused Outcomes;Patients;Pattern;Perception;Physicians;Play;Policies;Policy Maker;post-transplant;Process;prognostic;prognostic model;Qualifying;Research;Research Personnel;Resources;risk prediction;Role;Scientific Advances and Accomplishments;Scientist;Severity of illness;skills;System;Techniques;Testing;Time;Translating;transplant centers;Transplant Recipients;Transplantation;treatment choice;Variant;Waiting Lists;Work

PROJECT_TITLE: Developing a Donor-Candidate Risk Prediction System to Optimize Lung Allocation and Transplant Outcomes

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This proposal aims to decipher how two conserved output pathways from the retina to the brain cooperate to control gaze and mediate high-acuity binocular vision in a complex behavior (i.e., predation). Insights into the organization and function of visual pathways in health facilitate the identification of early disorganization and dysfunction in common diseases of the retina and the brain. In addition, knowledge about the function of specific pathways in visually guided behaviors establishes benchmarks for comparing competing strategies for vision restoration.

PI_NAMEs: KERSCHENSTEINER, DANIEL  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: 3-Dimensional;Ablation;Acute;Anatomy;Animals;Area;Back;Behavior;Behavioral;Benchmarking;Binocular Vision;Brain;Calcium;Cell Density;cell type;Cells;Code;Complex;Computer Models;Data;Data Set;density;Early identification;Electrophysiology (science);Excision;experimental study;follow-up;Functional disorder;ganglion cell;gaze;Genetic;genetic manipulation;Gryllidae;Health;high resolution imaging;Image;Immunohistochemistry;Impairment;in vivo;Individual;Inner Nuclear Layer;Insecta;insight;Ipsilateral;Knowledge;Label;Maps;Measures;Mediating;mosaic;Motion;Mus;Neurons;optic flow;Optics;Output;patch clamp;Pathway interactions;Population;Predatory Behavior;preference;receptive field;Reporting;response;Retina;Retinal Diseases;Retinal Ganglion Cells;sight restoration;Signal Transduction;Stains;Stimulus;superior colliculus Corpora quadrigemina;System;Testing;tool;Transgenic Organisms;two-photon;vestibulo-ocular reflex;Viral;Vision;Visual;Visual Fields;Visual Pathways;visual processing;visual stimulus

PROJECT_TITLE: Visual pathway cooperation to align viewing strategies and processing specializations for predation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: Arenaviruses, such as Junín and Lassa, cause severe life-threatening hemorrhagic fevers and are recognized as Category A priority pathogens and important targets for vaccine development. Despite use of the classically derived live-attenuated Candid#1 strain of Junín virus in Argentina to protect against Argentine hemorrhagic fever, this vaccine has not been licensed in the US in part due to concerns regarding the stability of attenuation, which relies on a single mutation in the virus envelope glycoprotein (GPC). In this proposal, we will capitalize on our understanding of GPC structure and function to design and characterize recombinant Candid#1 (rCan) viruses that enhance the genetic and phenotypic stability of attenuation, with the long-term goal of developing a safe and effective second-generation rCan vaccine.

PI_NAMEs: NUNBERG, JACK H (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acceleration;acute infection;Advanced Development;Amino Acids;Animals;Arenavirus;Argentina;Argentine;Argentinian Hemorrhagic Fever;Attenuated;attenuation;Biological Assay;C57BL/6 Mouse;Category A pathogen;Cavia;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Codon Nucleotides;Defect;design;Development;direct application;Disease;Ensure;Equilibrium;Generations;Genetic;genetic approach;Genetic Enhancement;Genetic Epistasis;Glycine;Glycoproteins;Goals;GP2 gene;Growth;guinea pig model;Human;Immunity;Immunization;Immunize;immunogenicity;Immunologics;Infection;International Agencies;Isoleucine;Junin virus;Laboratories;Laboratory Animals;Lassa;Lassa virus;Licensing;Licensure;Life;Lysine;Membrane Fusion;Membrane Fusion Activity;Modeling;Molecular;mouse model;Mus;Mutation;myristoylation;N-terminal;National Security;neutralizing antibody;novel;old mice;Peptide Signal Sequences;Peptides;Phenotype;Phenylalanine;Pilot Projects;Population;Positioning Attribute;priority pathogen;Production;Property;protective efficacy;Public Health;rational design;Recombinants;Reporting;response;Rodent;Safety;sample collection;Serial Passage;Serine;Standard Model;Structure;T cell response;Testing;transcriptome sequencing;transmission process;Vaccination;vaccine candidate;vaccine development;vaccine safety;Vaccinee;Vaccines;Variant;Viral Hemorrhagic Fevers;Virulence;Virulent;Virus;Virus Diseases;virus envelope;Virus Replication;Work

PROJECT_TITLE: Rational design of a safe recombinant Candid#1 vaccine

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]