ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE All animals encode and express long double-stranded RNA (dsRNA) that must be distinguished from viral dsRNA. The proposed research will use the model organism C. elegans, biochemistry, and structural biology, to elucidate pathways and mechanisms involved in distinguishing “self” from “nonself” dsRNA, ultimately providing information relevant to the health of all animals, including humans.

PI_NAMEs: BASS, BRENDA L. (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Animals;Anti-viral Response;Binding Proteins;Biochemical;Biochemistry;Caenorhabditis elegans;Deamination;design;Dicer Enzyme;Double-Stranded RNA;dsRNA adenosine deaminase;Enabling Factors;Enzymes;fascinate;Gene Silencing;Genetic Screening;Goals;Health;helicase;Human;Immune;Immune response;In Vitro;in vivo evaluation;Innate Immune Response;insight;Interferons;Invertebrates;Kinetics;Knowledge;Mammals;Mediating;model organism;Molecular;Molecular Motors;Pathway interactions;Process;Proteins;Research;RNA;RNA Editing;RNA Interference;RNA Interference Pathway;Role;Site;Small RNA;structural biology;Vertebrates;Viral;viral RNA

PROJECT_TITLE: Elucidating roles and mechanisms of double-stranded RNA-mediated pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-X(07)R]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE Research proposed here will uniquely advance knowledge of the physiological and perceptual relevance of olfactory oscillations in the human brain, and may enable us to infer mechanistic principles at the level of local neuron ensembles. Our findings should have a far-reaching impact not only on basic models of olfactory system function, but also more generally on the role of theta oscillations in neural information processing. Finally, given the high degree of overlap between the olfactory system and brain networks implicated in temporal lobe epilepsy, our studies may enhance understanding of the neurophysiological derangements underlying epilepsy, and could provide insights into establishing novel diagnostic interventions that improve spatial localization of epileptogenic foci in cases of non-lesional epilepsy.

PI_NAMEs: GOTTFRIED, JAY A (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Air;animal data;Animal Model;Animals;Area;Back;Basic Science;Behavior;Biological;Brain;Brain region;Categories;Clinical Research;Code;cognitive neuroscience;Coupling;design;Distant;Electric Stimulation;Electroencephalography;Electrophysiology (science);Emotional;Epilepsy;experimental study;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Future;Hippocampus;Human;Implanted Electrodes;improved;insight;Intervention;Knowledge;Laboratories;Literature;Medical;Memory;Methods;millisecond;Modeling;Molecular Structure;Nervous System Physiology;neural;neural information processing;Neurons;neurophysiology;Nose;novel;novel diagnostics;odor discrimination;Odors;olfactory bulb;Olfactory Cortex;Olfactory Pathways;Operative Surgical Procedures;Pathologic;Patients;Pattern;Pattern Recognition;Perception;Periodicity;Phase;Physiologic pulse;Physiological;piriform cortex;Play;Population;Population Dynamics;preclinical evaluation;Research;Resistance;Resolution;Role;Scalp structure;Seizures;Shapes;Signal Transduction;Smell Perception;spatiotemporal;Stimulus;Study models;Techniques;Temporal Lobe;Temporal Lobe Epilepsy;Testing;Time;tool;Work

PROJECT_TITLE: Spatiotemporal Mechanisms of Olfactory Processing in the Human Brain

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Lung;Nanotechnology

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: The proposed studies will elucidate the contribution of specific engineered nanomaterial properties that determine in vitro and in vivo toxicity, as well as provide mechanistic information to help develop therapeutic interventions to block their inflammation when inhaled. These results will also be used to help develop treatments to block inflammation caused by various particles including silicates. Finally, this information will be used to develop safer materials to protect workers and end users.

PI_NAMEs: HOLIAN, ANDRIJ  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Aerosols;Affect;Alveolar Macrophages;amphiphilicity;Animal Model;Applied Research;Asbestos;bafilomycin A;Biological;Biological Models;CASP1 gene;Cell Membrane Permeability;Cell Physiology;Cells;Characteristics;Charge;Chemistry;Cholesterol;commercial application;cytokine;cytotoxicity;design;Development;Disease;Dust;Engineering;Event;exposed human population;Exposure to;fundamental research;Goals;granite;hazard;Health;IL18 gene;Immune;In Vitro;in vivo;Industrialization;Inflammasome;Inflammation;Inflammatory;Inhalation;Injury;interest;Interleukin-1 beta;Knockout Mice;Knowledge;large-conductance calcium-activated potassium channels;Libraries;Lung Diseases;lysosome membrane;Lysosomes;Macrophage;Mediating;Membrane;metal oxide;Mitochondria;Modeling;nanoengineering;nanomaterials;Nanosphere;Nanotechnology;nanotoxicology;novel therapeutics;Occupational;Outcome;particle;particle exposure;Particle Size;Pathology;Pathway interactions;paxilline;Peptide Hydrolases;Phagolysosome;Phagosomes;Pharmaceutical Preparations;Phenotype;Preparation;prevent;Process;Property;Pulmonary Fibrosis;Pulmonary Inflammation;Pulmonary Pathology;Research;Resolution;response;Role;Signal Transduction;Silicates;Silicon Dioxide;Surface;Surface Properties;Systemic disease;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutically effective;titanium dioxide;Toxic effect;Uncertainty;Vesicle;water solubility;Wettability

PROJECT_TITLE: Role of particle surface functionalization in inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-H(03)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Diabetes;Digestive Diseases;Liver Disease;Nutrition

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Our proposed studies will unravel that the hyperglycemia-PKCα axis feedforward regulates the crosstalk between iron metabolism and diabetes. Hyperactive PKCα promotes intestinal iron absorption resulting in hepatic iron loading that in turn exacerbates liver injury related to diabetes. The current project may lead to the development of potential novel treatment modalities in diabetic control through the control of iron absorption.

PI_NAMEs: HE, PEIJIAN  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Accounting;Acetylation;Address;Adult;Albumins;Attenuated;Autophagocytosis;Binding;Biopsy;blood glucose regulation;Cessation of life;Cohort Studies;Complications of Diabetes Mellitus;cost estimate;Data;Dependence;Deposition;Development;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Dietary Iron;Disease;Duodenum;Engineering;Enterocytes;Epithelial Cells;Ferritin;Foundations;Genetically Engineered Mouse;Goals;Hepatic;Hepatocyte;hepcidin;Hyperactivity;Hyperglycemia;Impairment;improved;In Vitro;in vivo;Incidence;Inflammation;Inherited;inhibitor;insight;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;intestinal epithelium;Intestines;Iron;iron absorption;iron metabolism;Iron Overload;Knock-out;lenalidomide;Lipid Peroxidation;Liver;liver inflammation;liver injury;loss of function;Mediating;Membrane;metal transporting protein 1;microscopic imaging;Modality;Modeling;Molecular;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Pathogenesis;Pathologic;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phosphorylation;Play;Population;Prediabetes syndrome;PRKCA gene;Production;protein activation;Protein Kinase C;Publishing;Reactive Oxygen Species;receptor;Regulation;Risk Factors;Role;Serum;Severities;Signal Transduction;Site;SLC11A2 gene;Streptozocin;Testing;tissue injury;Type 2 diabetic;ubiquitin-protein ligase;Ubiquitination;United States;Up-Regulation;uptake;Work

PROJECT_TITLE: Mechanistic insights into the crosstalk between iron metabolism and diabetes

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Infectious Diseases;Lung;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Cystic fibrosis (CF) remains one of the most common, life-limiting genetic disorders due to chronic bacterial lung infections that do not respond to traditional antibiotic therapy. The proposed research will help us achieve a thorough understanding of how the immune system responds to treatment with novel CFTR modulators, and how these responses correlate with important clinical outcomes. The proposal is relevant to public health and the NIH’s mission as the findings will impact the treatment and understanding of immunodeficiencies and lung diseases associated with chronic bacterial infections and genetic or acquired CFTR dysfunction.

PI_NAMEs: AMER, AMAL O;HALL-STOODLEY, LUANNE ;KOPP, BENJAMIN T (contact);PARTIDA-SANCHEZ, SANTIAGO

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: 3-Dimensional;Affect;Antibiotic Therapy;Antibiotics;antimicrobial;Autophagocytosis;Bacteria;bacterial genetics;Bacterial Infections;Biological Assay;Burkholderia cepacia;Cell Physiology;Cells;Chronic;chronic infection;Clinical;Clinical Data;combat;Communities;Cystic Fibrosis;cystic fibrosis infection;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Delta F508 mutation;Disease;Exposure to;extracellular;Functional disorder;Generations;Genetic Diseases;Goals;Homeostasis;Human;Image Analysis;Immune;Immune response;Immune system;immunodeficiency;Impairment;improved;Individual;Infection;Inflammation;Inflammatory;innovation;insight;Ions;Knowledge;Life;Lung Diseases;Lung infections;Macrophage;Mediating;Metadata;Microscopy;Mission;Mitochondria;Modeling;monocyte;Mycobacterium abscessus;neutrophil;non-tuberculosis mycobacteria;novel;nutrition;Outcome;patch clamp;pathogen;Patients;personalized approach;personalized medicine;Persons;Phagocytes;Pharmaceutical Preparations;Process;Production;protein expression;Pseudomonas aeruginosa;Public Health;pulmonary function;Reactive Oxygen Species;reconstruction;Research;research clinical testing;Resolution;Resources;respiratory;response;restoration;Signal Transduction;Staphylococcus aureus;Testing;Therapeutic;trafficking;Translating;treatment response;United States National Institutes of Health;uptake;Variant;VX-770;VX-809;Western Blotting;Work

PROJECT_TITLE: Resue of CF phagocyte function with CFTR modulator therapy

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Mental Health;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Progress in preventing and treating mental illness requires training and supporting a diverse workforce of scientists who take a collaborative, translational approach to research. The proposed Career Development Institute for Psychiatry (CDI) will continue a nearly 20-year program of career skills training, mentoring, and community building to foster that workforce by helping early-career scientists at a vulnerable and important time in their professional development.

PI_NAMEs: FORBES, ERIKA E (contact);SCHATZBERG, ALAN F.

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Applications Grants;Appointment;Behavioral Sciences;Biomedical Engineering;career;career development;Clinical;Collaborations;Communication;Communities;community building;Country;Coupled;Creativeness;Development;Diverse Workforce;doctoral student;Education Projects;Educational workshop;Environment;equity, diversity, and inclusion;Evaluation;experience;Faculty;faculty community;flexibility;Fostering;Foundations;Goals;improved;Individual;interdisciplinary approach;Leadership;Learning;Manuscripts;Marketing;Mediation;medical specialties;meetings;member;Mental disorders;Mental Health;Mentors;Methods;Mission;Modeling;National Institute of Mental Health;Neurosciences;outreach;peer coaching;Persons;Phase;Physicians;Positioning Attribute;Postdoctoral Fellow;prevent;Prevention;Productivity;Professional Competence;Program Development;Program Evaluation;programs;Psychiatry;Psychology;Public Health;Recommendation;recruit;Research;Research Ethics;Research Personnel;Research Training;Residencies;resilience;responsible research conduct;Science;Scientist;Self Assessment;Self-Examination;skills;skills training;Strategic Planning;Structure;success;symposium;Talents;Time;Training;translational approach;Translational Research;translational scientist;Underrepresented Minority;United States;Universities;Wages;web site;webinar;Woman;Work;Writing

PROJECT_TITLE: The Career Development Institute for Psychiatry


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Substance Misuse;Telehealth

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Patients with comorbid substance use (SUD) and anxiety disorders (AD) experience increased risk for relapse and require novel integrative treatment strategies leveraging new technologies. The Unwinding Anxiety (UA) mobile app can fulfil this need for a digital, evidence-based training in a manualized, scalable, and high-fidelity manner. We will comprehensively investigate user experience of UA for patients with SUD-AD and identify customizations to develop a scalable evidence-based intervention for comprehensive integrative therapies.

PI_NAMEs: NARDI, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Address;Adult;Affect;Anxiety;Anxiety Disorders;anxiety treatment;Applications Grants;behavioral health;Caring;Clinical;Collection;comorbidity;Comprehensive Health Care;craving;Data;design;digital;digital delivery;digital health;digital treatment;Distress;Eating Disorders;effectiveness testing;Emotional;evidence base;Evidence based intervention;Evidence based treatment;experience;Focus Groups;follow-up;Funding;Future;Generalized Anxiety Disorder;health care settings;Health Technology;improved;Individual;informant;Integrative Therapy;Interview;Learning Module;Lived experience;long term recovery;Manuals;Measures;Mental Health;mental health organization;mHealth;mobile app development;mobile application;Mobile Health Application;National Institute of Drug Abuse;new technology;novel;Outcome;Participant;Pathway interactions;patient oriented;Patient-Focused Outcomes;Patients;Persons;Pharmacotherapy;polysubstance use;poor health outcome;Postdoctoral Fellow;Preparation;programs;psychoeducation;Psychotherapy;Quality of life;Recovery;Recovery Support;relapse risk;Reporting;Research;Research Design;Research Methodology;Resources;Role;smoking cessation;social stigma;substance use;substance use treatment;System;Testing;Therapeutic;Training;treatment of anxiety disorders;treatment program;treatment strategy;United States National Institutes of Health;usability;virtual;Work

PROJECT_TITLE: Developing an adjunctive mobile application for co-morbid substance use and anxiety disorders: comprehensive user experience testing of the Unwinding Anxiety application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PHR: NARRATIVE The Utah Clinical & Translational Science Institute (CTSI) and its local, regional, and national partners and collaborators develop, implement, and disseminate new translational science methods, tools, techniques, and best practices to support translational research. The Utah CTSI facilitates collaborations with patient, clinical, and community stakeholders and trains the next generation of the translational workforce. Together, these efforts aim to increase the efficiency and effectiveness of translational research, and ultimately improve the health of our population—reducing health disparities and increasing equity.

PI_NAMEs: HESS, RACHEL  (contact);MAJERSIK, JENNIFER JUHL

PROGRAM_OFFICER_NAME: DIBELLO, ANTHONY THOMAS

PROJECT_TERMS: Acceleration;Address;Award;bench to bedside;Biomedical Research;Caring;Clinic;Clinical;Clinical and Translational Science Awards;Clinical Data;Clinical Research;Clinical Sciences;Collaborations;Communities;community engagement;Country;Data;design;Development;Dissemination and Implementation;Ecosystem;Education;Effectiveness;effectiveness research;Elderly;Ensure;Equity;Ethics;Ethnic Population;Evaluation;experience;Extramural Activities;Fostering;Foundations;frontier;Funding;Genetic;Health;health disparity;health equity;Health Services;Hearing;Hematologist;Hereditary Disease;HIV;improved;Individual;Informatics;Infrastructure;innovation;Institution;Internal Medicine;International;Investments;Knowledge;Leadership;Lesbian Gay Bisexual Transgender Queer;Life Cycle Stages;Measurable;medical schools;member;Metabolic Diseases;Methods;Mission;Modeling;Modernization;Muscular Dystrophies;National Center for Advancing Translational Sciences;next generation;novel;Participant;Patients;Population;pre-exposure prophylaxis;Program Development;programs;Provider;Race;Recording of previous events;Reduce health disparities;Reproducibility;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Rural;Science;Scientist;Series;Services;social health determinants;Social Justice;Strategic Planning;structural biology;Sum;Techniques;Testing;tool;Training;Translating;translational pipeline;Translational Research;United States National Institutes of Health;Universities;Utah;Vision;Voice;Workforce Development

PROJECT_TITLE: CTSA UM1 Program at University of Utah


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Youth-onset type 2 diabetes (T2D) is increasing in prevalence and is accompanied by a greater degree of insulin resistance, more rapid deterioration of β-cell function, and earlier onset of life-threatening complications than seen in adults. However the causes and biomarkers of youth-onset T2D are not well-understood. We will bring our expertise in research methods, recruitment and retention of youth and their families, as well as lessons learned from our stakeholder engagement activities to help the Consortium design and implement a longitudinal study to identify youth at greatest risk and identify the factors driving this growing public health problem.

PI_NAMEs: GALLAGHER, MARY PATRICIA (contact);JACOBSON, ALAN M

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: 19 year old;Address;Adult;Advanced Glycosylation End Products;Affect;Age;Animals;Area;Automobile Driving;Basic Science;behavioral economics;Beta Cell;Biological Markers;Black race;Body mass index;built environment;cardiometabolism;Caring;Cell Physiology;Characteristics;chemical association;Chemical Exposure;Chemicals;Child;Clinical;clinical center;cohort;Collaborations;Communities;community research;Complex;Data;Data Collection;design;Deterioration;Development;Diabetes Mellitus;diabetes risk;Disease;Disease Progression;disorder risk;early onset;Enrollment;Ensure;environmental chemical;Environmental Exposure;Environmental Hazards;Environmental Risk Factor;epigenome;Evaluation;experience;Exposure to;Failure;Family;Family health status;Food;food environment;food resource;Functional disorder;gene environment interaction;Genetic;Health;Healthcare Systems;High Prevalence;high risk;Hospitals;Human;Human Subject Research;Incidence;Individual;Inflammation;Institution;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;interest;Intervention;Investigation;Kidney Diseases;Latinx;Life;Life Style;Long Island;Longitudinal Studies;Low income;Measurement;Measures;meetings;Mental Depression;Metabolism;metabolome;microbiome;Microvascular Dysfunction;Modification;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;Obesity;obesity risk;Onset of illness;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Physical activity;Population;Population Heterogeneity;Poverty;predictive marker;predictive modeling;Prevalence;prevent;Process;prognostic;Prospective, cohort study;Proteome;Protocols documentation;psychosocial;Psychosocial Factor;Public Health;receptor for advanced glycation endproducts;recruit;Research;Research Methodology;Research Personnel;response;Risk;Risk Factors;Role;safety net;Seminal;Severities;Site;Social Environment;social health determinants;societal costs;Source;success;Systems Integration;Therapeutic;therapeutic target;transcriptome;United States;urban setting;Youth

PROJECT_TITLE: Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes- NYU Clinical Center


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE Excess fetal adipose tissue growth during intrauterine development increases future obesity risk. Development of brown adipose tissue, a highly thermogenic organ in utero, may affect postnatal energy expenditure, thus influencing obesity risk. This novel mentored F32 application is designed to understand the developmental origins of energy balance by examining maternal and neonatal factors that influence neonatal brown adipose tissue and to quantify its physiological relevance to energy expenditure in human neonates.

PI_NAMEs: FLANAGAN, EMILY W (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Adipose tissue;Adult;Affect;Anatomy;Attenuated;Biomedical Research;Birth;Birth Weight;Body mass index;Brown Fat;career;Characteristics;Clinical assessments;Clinical Trials;Data;Data Collection;design;Development;Differentiation and Growth;energy balance;Energy Metabolism;Environment;Equilibrium;Expenditure;experience;Fatty acid glycerol esters;Fatty Acids;Fellowship;fetal;Funding;Future;gestational weight gain;global health;Glucose;Goals;group intervention;Growth;Histologic;Human;in utero;Individual;Infant;intrauterine environment;Knowledge;Learning;Life;lifestyle intervention;Lipids;Magnetic Resonance Imaging;Maternal Health;Measurement;Measures;Mentors;Methodology;Methods;Mothers;natural hypothermia;Neonatal;neonate;newborn adiposity;novel;Obesity;obesity in children;obesity risk;offspring;Organ;Phenotype;Physiologic Thermoregulation;Physiological;Physiology;postnatal;Pregnancy;Pregnant Women;prenatal;Prenatal care;prenatal intervention;prepregnancy;Principal Investigator;programs;Property;Publications;Randomized;Research;Research Personnel;response;Rest;Role;sex;Signal Transduction;skills;Supraclavicular;Testing;Thermogenesis;Time;Tissues;Training;training opportunity;transmission process;treatment as usual;United States National Institutes of Health;Water;weight maintenance;women versus men

PROJECT_TITLE: An Examination of Brown Adipose Tissue and Energy Expenditure in Infants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-A(20)L]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Endocrine Disruptors;Health Effects of Indoor Air Pollution;Immunization;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Semi-volatile organic compounds (SVOCs) are ubiquitous environmental contaminants, and human exposure is widespread. We will investigate whether early-life exposure to SVOCs adversely affects children’s immunity to common pathogens. Identifying modifiable environmental factors that influence the development and function of the immune system has long-term implications for improving health.

PI_NAMEs: HOFFMAN, JENNIFER K (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Active immunity;Affect;Age Months;Allergic;Animals;Antibodies;Antibody Formation;Antibody Response;Antigens;Autoimmune Diseases;Binding;Birth;Blood specimen;building materials;cell mediated immune response;Cellular Immunity;Characteristics;Chemicals;Child;Child Health;Childhood;cohort;Cohort Studies;Collection;Communicable Diseases;Data;design;Developed Countries;Development;Diphtheria-Tetanus-acellular Pertussis Vaccines;Disease;early childhood;early life exposure;Electronics;emerging pathogen;environmental chemical;Environmental Exposure;Environmental Impact;Environmental Pollutants;Environmental Risk Factor;epidemiology study;Esters;experience;exposed human population;Exposure to;Fetus;Flame Retardants;follow-up;Frequencies;Furniture;General Population;Goals;Health;Hospitalization;Human;IgG Receptors;Immune;immune function;immune health;Immune response;Immune system;immune system function;Immunity;Immunoglobulin G;immunoregulation;Impairment;improved;In Vitro;Incidence;Individual;Indoor environment;infancy;Infant;infant morbidity;infant morbidity/mortality;Infant Mortality;Infection;influenza virus vaccine;Infrastructure;Intervention;Life;Maternal antibody;Measurement;Measures;Medical;Modeling;Monitor;Morbidity - disease rate;mortality;multiplex assay;Mus;neoantigens;Neonatal;neonate;neutralizing antibody;novel;Organophosphates;Outcome;Passive Transfer of Immunity;pathogen;personal care products;Pesticides;phthalates;Placenta;placental transfer;Plasticizers;Play;Policies;Population;Predisposition;Pregnancy;Pregnancy Trimesters;prevent;Property;prospective;Prospective cohort;Public Health;Reporting;Research;Resources;response;Role;seasonal influenza;Silicones;Specimen;Systems Development;Technology;Testing;Umbilical Cord Blood;Vaccination;vaccine immunogenicity;vaccine response;Vaccines;volatile organic compound;Woman;wristband

PROJECT_TITLE: Impact of Early-life Exposure to Semi-Volatile Organic Compounds (SVOCs) on Neonatal and Early Childhood Immune Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Substance Misuse;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Project Narrative Despite the relevance of the pro-stress corticotropin-releasing factor and norepinephrine and the anti-stress nociceptin systems in the sexually dimorphic behavioral aspects of AUD, their sex-specific cellular mechanisms and interactions in the amygdala have not been fully delineated. Thus, this proposal will elucidate the neuroadaptive changes induced by ethanol dependence and withdrawal in these systems in the amygdala. Identifying the potential neuroadaptations occurring with chronic alcohol is essential for the development of more effective targeted pharmacotherapeutics for treatment of AUD sufferers.

PI_NAMEs: ROBERTO, MARISA  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Abstinence;Accounting;Acute;addiction;Adrenergic Receptor;alcohol abstinence;Alcohol abuse;alcohol abuse therapy;alcohol availability;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholic Intoxication;Alcoholism;Alcohols;Amygdaloid structure;Anxiety;anxiety-like behavior;Behavior;Behavioral;behavioral study;beta-adrenergic receptor;Brain;Cell Nucleus;Chronic;Complex;compulsion;Compulsive Behavior;Corticotropin-Releasing Hormone;Cre driver;Data;design;Development;Disease;drug withdrawal;dysphoria;Electrophysiology (science);Elements;Equilibrium;Ethanol;Ethanol dependence;Female;gamma-Aminobutyric Acid;glutamatergic signaling;Immunohistochemistry;Immunology procedure;In Situ Hybridization;In Vitro;Individual Differences;insight;Intake;interdisciplinary approach;Laboratories;Lead;locus ceruleus structure;male;Mediating;Molecular;Molecular Biology;negative affect;negative emotional state;Negative Reinforcements;neuroadaptation;Neurons;Neurophysiology - biologic function;Neurotransmitters;nociceptin;Norepinephrine;norepinephrine system;novel;Opioid;Pathway interactions;Pattern;Peptides;Play;Population;preclinical study;Predisposition;prevent;Psychological reinforcement;Public Health;Rattus;receptor;recruit;Regulation;Relapse;Research;Research Personnel;Rodent;Role;sex;Sex Differences;sexual dimorphism;Shapes;Signal Transduction;Stress;Synapses;System;Testing;Therapeutic;tool;Transgenic Organisms;transmission process;treatment strategy;Withdrawal;Withdrawal Symptom;withdrawal-induced anxiety

PROJECT_TITLE: Synaptic Mechanisms underlying sex-differences in alcohol use disorder

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Childhood Obesity;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world, affecting 8% of all children and 34% or more of those with obesity. This study will determine and validate the role of skin surface lipids, which can be collected using painless tape stripping, as novel, non-invasive biomarkers of disease presence and severity in youth with NAFLD. The results have the potential to revolutionize clinical practice and to enhance therapeutic discovery, which is currently limited by the need for invasive liver biopsies to accurately detect and stage disease severity.

PI_NAMEs: MOUZAKI, MARIALENA  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: 21 year old;Acceleration;Adult;advanced disease;Affect;Age;Alanine Transaminase;Animal Model;arm;Attenuated;Biological Markers;biomarker development;Biopsy;Ceramides;Characteristics;Child;Childhood;Cirrhosis;Clinical;clinical practice;cohort;Collection;Cutaneous;density;Dermal;Diabetes Mellitus;Diagnostic;Diet;Disease;disorder control;drug development;Endocrine;Fatty acid glycerol esters;Fatty Liver;Feces;Fibrosis;Foundations;Health;Hepatic;High Pressure Liquid Chromatography;Histologic;Histology;Human;Immune;Incidence;Insulin Resistance;lipidome;lipidomics;Lipids;Liver;liver biopsy;Liver diseases;Liver Fibrosis;Magnetic Resonance Imaging;Masks;metabolomics;Methodology;microbiome;Modality;Monitor;Multicenter Studies;non-alcoholic fatty liver;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;noninvasive diagnosis;novel;Obesity;obesity in children;Painless;Participant;Pathogenesis;Pathologist;patient subsets;Patients;pediatric non-alcoholic fatty liver disease;Pediatrics;Performance;pharmacologic;Pharmacotherapy;Plasma;Prevalence;Procedures;progression marker;Protons;Puberty;Race;recruit;Research;Role;Sampling;screening;Seasons;Sebaceous Glands;Serum;Severities;Severity of illness;sex;Skin;stool sample;Stratum corneum;Surface;Testing;Therapeutic;therapeutic development;time of flight mass spectrometry;Transplantation;treatment response;United States Food and Drug Administration;urinary;Validation;Venipunctures;weight loss intervention;young adult;Youth

PROJECT_TITLE: Cutaneous biomarkers of pediatric non-alcoholic fatty liver disease

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Brain Disorders;Breast Cancer;Cancer;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Women's Health Research

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE Breast cancer brain metastasis (BCBM) is a lethal malignant disorder with prominent breast cancer cell growth to cause malformations and dysfunctions in brain. Our proposed research aims to determine the molecular mechanisms of astrocytes in the initiation and progression of BCBM. The proposal has strong clinical relevance to understand the novel mechanisms of neuropathological impact on breast cancer patients and other malignant diseases with brain colonization.

PI_NAMEs: WANG, CHENRAN  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Aging;anti-tumor immune response;Arteries;Astrocytes;astrogliosis;Autophagocytosis;Biological;Biology;Blood - brain barrier anatomy;Brain;Brain Neoplasms;brain parenchyma;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;breast cancer survival;Breast Cancer Treatment;cancer cell;Cancer Cell Growth;Cancer Patient;cancer stem cell;cancer subtypes;Cell Maintenance;Cells;Cerebrovascular Circulation;Cerebrum;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Communicable Diseases;conditional knockout;Cytoplasm;Data;Dependence;Development;Developmental Process;Disease;Disseminated Malignant Neoplasm;effective therapy;Essential Genes;Exposure to;Functional disorder;Genes;genetic approach;Growth;Homeostasis;Human;human embryonic stem cell;human model;Immunosuppression;Incidence;induced pluripotent stem cell;Infiltration;inhibition of autophagy;Injections;innovation;insight;Intracarotid;Investigation;Knockout Mice;Knowledge;Lesion;malformation;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;MCF7 cell;MDA MB 231;Mediating;Mediator;Metabolic;Metabolic Diseases;metastasis prevention;Metastatic malignant neoplasm to brain;Methods;Microglia;Micrometastasis;Modeling;Molecular;Molecular Biology;Monitor;mouse genetics;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;Neurodegenerative Disorders;Neuroglia;Neurons;neuropathology;neurotransmission;Nonmetastatic;novel;Oncogenic;Organelles;Organoids;paracrine;Paracrine Communication;Pathologic;Pathway interactions;Patients;pharmacologic;Physiological;polyoma middle tumor antigen;pressure;prevent;Prevention;Primary Brain Neoplasms;Primary Neoplasm;Process;Prognosis;Proliferating;Quality of life;Reporter;Research;Resistance;response;Role;Sampling;self organization;Signal Pathway;Stat3 protein;stem cell technology;Stratification;Structure;Synapses;System;Therapeutic;translational approach;triple-negative invasive breast carcinoma;Tropism;tumor;tumor microenvironment;tumor progression;Tumor Promotion;Woman

PROJECT_TITLE: Roles of Glial Autophagy in Breast Cancer Brain Metastasis

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Drugs of abuse share the common property of increasing dopamine release in a key brain structure, the nucleus accumbens. This proposal uses innovative experiments with the goal of better understanding how dopamine signals in this structure alter learning and motivation.

PI_NAMEs: BERKE, JOSHUA D (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Address;Adenosine;Affect;Anesthesia procedures;Animals;Area;Axon;Behavior;behavior influence;Behavioral;Brain;Cell Physiology;Cells;Chemicals;cholinergic;Cholinergic Receptors;Communities;Computer Models;Corpus striatum structure;Cues;Data;Data Set;discount;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;dopaminergic neuron;Dorsal;drug of abuse;Electrophysiology (science);expectation;experimental study;Feedback;Funding;Future;Goals;Heterogeneity;Individual;Influentials;innovation;Interneurons;Label;Lateral;Learning;Measurement;Measures;Medial;Mediating;Methods;Midbrain structure;Monitor;motivated behavior;Motivation;neural circuit;Neurons;Nicotinic Receptors;novel;Nucleus Accumbens;Optics;optogenetics;Output;Pathologic;Pattern;pharmacologic;Population;programs;Property;Psychological reinforcement;Ramp;Rattus;receptor;Research;response;reward anticipation;Rewards;Role;sensor;Shapes;Signal Transduction;Slice;Structure;Substance abuse problem;Synaptic plasticity;Testing;theories;Time;Travel;Uncertainty;Update;Ventral Tegmental Area;willingness;Work

PROJECT_TITLE: Dopaminergic mechanisms for motivation and reinforcement learning

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: LEXINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE This project will develop statistical methods and use multi-regional International epidemiology Databases to Evaluate AIDS (IeDEA) data to support a worldwide evaluation of the Treat-All policy regarding the global HIV/AIDS epidemic. The methods will bring robustness in understanding HIV disease evolution subjected to data complexities, the effectiveness of WHO's Treat-All policy, and the patient, clinic, and country characteristics that modify the policy's impact. In addition, the findings from this project may lead to the development of more precise intervention and resource-allocation options that take these factors into account and ultimately improve overall outcomes for people living with HIV.

PI_NAMEs: NASH, DENIS ;ZHANG, HONGBIN  (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adopted;Adoption;African;antiretroviral therapy;Binding;Caring;CD4 Lymphocyte Count;Cells;Central Africa;Cessation of life;Characteristics;Clinic;Clinical;clinically relevant;cohort;Country;Data;Data Collection;data complexity;data imputation;Databases;demographics;design;Development;Diagnosis;Disease;disease model;Disease Progression;Effectiveness;Eligibility Determination;Enrollment;Ensure;Epidemic;Epidemiology;Evaluation;Event;Evolution;follow-up;Future;Guidelines;hazard;HIV;HIV/AIDS;improved;Individual;International;Intervention;Investigation;Laboratories;Methods;Modeling;mortality;Outcome;outreach;Patient Care;Patient-Focused Outcomes;Patients;Performance;Persons;Pharmaceutical Preparations;Policies;Policy Analysis;Policy Developments;Population Heterogeneity;Probability;Procedures;Prognostic Factor;Randomized, Controlled Trials;Recommendation;Recording of previous events;Research;Research Personnel;Resource Allocation;Sample Size;Sampling;Selection Bias;semiparametric;Severity of illness;Statistical Methods;Structure;Testing;Time;trial design;Validation;Withdrawing Care;Work;World Health Organization

PROJECT_TITLE: Developing Statistical Methods on Event History Data Subject to Data Complexities for HIV Disease Progression and Policy Evaluation

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: ADDITIONAL NARRATIVE JUSTIFICATION The budget years are not even modules because in year one we will simultaneously work on all three aims which will require the support of 2 full graduate students. In year 2, effort will shift toward Aim 3, requiring the support of 1.5 graduate students.

PI_NAMEs: PEPPAS, NICHOLAS A (contact);ZOLDAN, JANETA

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Adhesions;Affect;arm;Autocrine Communication;Behavior;Binding Sites;Biochemical;biomaterial compatibility;Biophysics;Blood;Bone Marrow;Budgets;Categories;Cell Adhesion;cell behavior;Cell Communication;Cell Culture Techniques;Cell Differentiation process;Cell Proliferation;cell type;Cells;Chemicals;Crosslinker;curative treatments;cytokine;Cytokine Signaling;Dependence;design;Diffusion;Disease;dithiol;Encapsulated;Environment;ethylene glycol;Extracellular Matrix;Formulation;Genetic Diseases;Goals;graduate student;hematopoietic stem cell expansion;hematopoietic stem cell niche;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homeostasis;Human;Hydrogels;Immune;Immune system;improved outcome;In Vitro;insight;Integrin alpha5beta1;Integrin Binding;Knowledge;Libraries;Long-Term Effects;Malignant Neoplasms;mechanical signal;Methods;Modeling;Morbidity - disease rate;Motivation;novel;Outcome;Paracrine Communication;Peptides;Phenotype;Physical environment;physical property;Play;predictive modeling;Proliferating;Property;Research;response;Role;scaffold;self-renewal;Signal Transduction;solute;stem cell survival;stemness;success;System;Testing;theories;Time;Tissues;transplantation therapy;Umbilical Cord Blood;Uncertainty;Variant;Work

PROJECT_TITLE: Decoupling Hydrogel Stiffness and Diffusivity for Hematopoietic Stem Cell Culture and Differentiation

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Nutrition

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Identification of the growth factor pathways involved in cell fate specification of peripheral oral sensory neurons may shed light on the regenerative capacity of these neurons and their target taste buds. Furthermore, these molecular mechanisms are likely to be involved in the phenotypic maintenance of oral sensory neurons throughout the lifespan, thereby providing new strategies for the recovery of the taste system after injury or during disease states.

PI_NAMEs: PIERCHALA, BRIAN ANTHONY (contact)

PROJECT_TERMS: Adult;Afferent Neurons;Aging;anaplastic lymphoma kinase;Anterior;Brain;Brain Stem;Brain-Derived Neurotrophic Factor;cancer therapy;cell fate specification;Cells;Chemical Stimulation;chorda tympani;cold temperature;Communication;comorbidity;Complex;Dependence;Development;Disease;Electrophysiology (science);Epitopes;Esthesia;experimental study;Family;feeding;Fiber;FOXG1B gene;Fungiform Papilla;Ganglia;Gene Expression;Genes;Genetic;glial cell-line derived neurotrophic factor;Growth;Growth Factor;Growth Factor Receptors;Impairment;in vivo;inhibitor;Injury;kinase inhibitor;Life;life span;Ligands;Link;Maintenance;Malignant neoplasm of lung;Mechanoreceptors;Messenger RNA;Methods;Molecular;Morphology;multimodality;Mus;Nerve;Nerve Fibers;nerve supply;Neuronal Differentiation;Neurons;neurotrophic factor;Oral;oral sensory;Organ;Pathway interactions;Pattern;Perception;Peripheral;Phenotype;Physiological;Physiology;Population;postnatal;Presynaptic Terminals;receptor;Receptor Activation;Recovery;Regenerative capacity;Reporter;response;ribosome profiling;Ribosomes;RiboTag;Role;Schwann Cells;selective expression;Sensory;sensory system;side effect;Signal Pathway;Signal Transduction;Specific qualifier value;Stimulus;Structure;Structure of geniculate ganglion;Surface;System;tactile stimulation;Taste Buds;Taste Perception;taste system;Temperature;Testing;Therapeutic;Tongue;transcription factor;transcriptome sequencing;Transgenic Mice;Trigeminal System;Virus Diseases;Visceral

PROJECT_TITLE: Growth factors in the development and physiology of geniculate taste neurons

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: MILWAUKEE

ORG_NAME: CHILDREN'S HOSPITAL OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE This study will determine how to successfully implement H-HOPE, a known efficacious developmental behavioral intervention, in neonatal units. These data are vital to deliver early interventions that can promote preterm infant growth and development, improve public health and reduce cost.

PI_NAMEs: BRANDON, DEBRA H;NORR, KATHLEEN F;WHITE-TRAUT, ROSEMARY C (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Acceleration;acute care;Address;Affect;Age;Auditory;Behavior;Behavior Therapy;Brain;Characteristics;Chronology;clinical practice;clinical research site;cohort;Consolidated Framework for Implementation Research;cost;Cost Savings;Data;design;Development;Early Intervention;Effectiveness;effectiveness evaluation;effectiveness outcome;Eligibility Determination;Enrollment;Environment;evidence base;experience;Eye;Funding;Growth;Growth and Development function;Health;Health Care Costs;health care service utilization;Healthcare;Home;Hospital Costs;Hospitalization;Hospitals;Hybrids;implementation evaluation;implementation framework;implementation outcomes;implementation process;implementation science;implementation strategy;implementation/effectiveness;improved;Individual;Infant;Infant Behavior;Infant Care;Infant Development;Infant Health;infant outcome;Intervention;Interview;Investments;Length of Stay;Massage;Measures;Methods;Modeling;Mothers;multisensory;Neonatal;Neonatal Intensive Care Units;Outcome;Outcomes Research;Parents;Patient Self-Report;Patients;Phase;post implementation;Premature Infant;primary outcome;programs;Protocols documentation;Public Health;Recommendation;Records;Reporting;Research;Safety;Services;Site;Social Interaction;Social support;standard of care;Standardization;Stress;Structure;success;Tactile;Testing;Time;Touch sensation;United States National Institutes of Health;Variant;vestibular system;Visit;Visual;Voice

PROJECT_TITLE: Implementation of an Evidence Based Parentally Administered Intervention for Preterm  Infants.

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;HIV/AIDS;Human Genome;Infectious Diseases

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Quality of life remains suboptimal for people living with HIV taking anti-retroviral drugs due to persistent infection and its negative impact on health. Persistent infection generates virus RNA and protein that contributes to chronic low level immune activation. This project will focus on the therapeutic potential of reducing viral RNA and protein burden by understanding and altering the chemical state of HIV RNA.

PI_NAMEs: GAGNON, KEITH THOMAS (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Anti-HIV Agents;Anti-Retroviral Agents;antiretroviral therapy;base;Binding;Biology;CD4 Positive T Lymphocytes;Cell Separation;Cells;Chemicals;Chronic;chronic infection;Coupling;Disease;drug discovery;Enzymes;epitranscriptome;epitranscriptomics;experimental study;Family;Fluorescence;Fluorescent in Situ Hybridization;Gene Expression;gene function;Genetic;Genetic Transcription;Guide RNA;Health;HIV;HIV Infections;Immune;immune activation;immune health;Immune system;improved;Infection;interest;knock-down;Knock-out;Life;Macrophage;Metabolism;Methodology;Methods;Modality;Modeling;Modification;Molecular Disease;nanopore;next generation sequencing;nucleic acid-based therapeutics;Nucleic Acids;Oligonucleotides;Output;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase;Play;posttranscriptional;prevent;Process;Production;protein expression;Proteins;Proviruses;Quality of life;Regulation;Residual state;ribosome profiling;RNA;RNA Biochemistry;RNA metabolism;RNA Processing;RNA Stability;Role;Site;Systemic disease;T-Lymphocyte;Testing;Therapeutic;therapeutic candidate;Therapeutic Intervention;Transcript;transcriptome;transcriptome sequencing;Translations;translatome;Viral;Viral Load result;Viral Proteins;viral RNA;virology;Virus;Virus Replication;Work

PROJECT_TITLE: Coupling Epitranscriptomics to Molecular Disease Mechanisms and Nucleic Acid Therapeutics in Persistent Residual HIV Infection


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Maternal Health;Pediatric;Pediatric - AIDS;Pregnancy;Prevention;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE Daily oral HIV pre-exposure prophylaxis with emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) has been shown to reduce new HIV infections in different settings. When used in pregnancy, however, the standard FTC/TDF dose is associated with lower drug concentrations, raising concerns about reduced efficacy. We seek to identify and evaluate the optimal FTC/TDF dose for pregnant women, with a focus on pharmacokinetic and safety outcomes. Our study will be conducted in Zimbabwe, where—like much of sub-Saharan Africa—the burden of HIV is high and the need for HIV prevention is great.

PI_NAMEs: ANDERSON, PETER L.;CHI, BENJAMIN H. (contact);STRANIX-CHIBANDA, LYNDA

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: Adherence;Adverse event;adverse pregnancy outcome;Africa South of the Sahara;AIDS prevention;Area;Award;Benchmarking;Birth;Body Weight;Body Weight Changes;bone;Bone Density;Breast Feeding;cervicovaginal;Clinical;Clinical Trials;Creatinine clearance measurement;Data;design;Diphosphates;Discipline of obstetrics;Dose;Drug Kinetics;Effectiveness;emtricitabine;Erythrocytes;Evaluation;Event;experience;Face;follow-up;Fumarates;Future;Gestational Age;Goals;Growth;Hematology;Hepatitis B Therapy;high risk;high risk population;HIV;HIV Infections;Hour;Infant;infant outcome;insight;Institution;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;Kidney;Life;Liquid substance;Measures;Modeling;Monitor;multidisciplinary;Oral;oral HIV;Outcome;Participant;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacokinetic model;Pharmacology;Phase;Plasma;Population;post pregnancy;Postpartum Period;pre-exposure prophylaxis;predictive modeling;Pregnancy;Pregnancy Outcome;Pregnancy Trimesters;pregnant;Pregnant Women;primary outcome;Prophylactic treatment;Randomized;Recommendation;Regimen;Renal function;Reporting;Research Infrastructure;Research Personnel;Safety;safety assessment;safety outcomes;Sampling;Second Pregnancy Trimester;Tenofovir;Therapeutic Equivalency;Third Pregnancy Trimester;Time;Universities;Urine;Woman;women's outcomes;Zimbabwe

PROJECT_TITLE: Optimizing PrEP regimens for pregnant women in sub-Saharan Africa

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: BOSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative Our goal is to elucidate the mechanisms governing the regulation of cardiac and skeletal muscle contraction at a fundamental molecular level by determining the atomic structures and changing interactions of muscle proteins that control muscle activation and relaxation. A complete understanding of muscle regulatory switching mechanisms is essential to define how mutations linked to the muscle control proteins perturb muscle activation and relaxation and then lead to cardiomyopathies and skeletal muscle disease. In turn, our atomic level structures provide a platform to design compounds that specifically target the control proteins to modulate muscle activation or relaxation and thus will be able to reverse initial stage pathophysiology and delay or treat disease progress and symptoms.

PI_NAMEs: LEHMAN, WILLIAM J (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Actin-Binding Protein;Actins;Actomyosin;Address;Affect;Binding;Biochemical;Biochemistry;Biological Assay;Biomedical Research;Boston;C-terminal;Cardiac;Cardiac Muscle Contraction;cardiac tissue engineering;Cardiomyopathies;Clinical;Collaborations;Communication;Complex;Computer Models;computerized tools;Coupled;Cryoelectron Microscopy;Data;Defect;defined contribution;design;Disease;Disease Outcome;Disease Progression;Docking;drug development;druggable target;Face;Filament;Functional disorder;Genes;Genetic;genetic regulatory protein;Goals;Head;Heart;heart function;Homeostasis;image reconstruction;In Vitro;in vitro Assay;Individual;insight;Intervention;Lead;Left;Link;link protein;Location;Measures;Microfilaments;Modeling;Molecular;Molecular Conformation;molecular dynamics;Motility;Muscle;Muscle Contraction;Muscle Proteins;Muscle relaxation phase;mutant;Mutation;Myocardium;Myopathy;Myosin ATPase;Pathologic;Pathway interactions;Penetrance;Phenotype;Physiological;Physiology;Play;Positioning Attribute;Process;Proteins;Protocols documentation;reconstruction;Regulation;Regulatory Pathway;Relaxation;Research;Research Personnel;response;Restrictive Cardiomyopathy;Role;Severities;Signal Pathway;Site;Skeletal Muscle;small molecule;Specific qualifier value;Structure;Symptoms;synergism;Tail;Testing;Thin Filament;Three-Dimensional Image;Tissue Model;Tissues;tool;Translations;Tropomyosin;Troponin;Universities;Work;X-Ray Crystallography

PROJECT_TITLE: Thin Filaments and Muscle Regulation

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Obesity

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: NARRATIVE Nonalcoholic fatty liver disease (NAFLD) is a common comorbidity of type 2 diabetes (T2D) that can progress to nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. The increased prevalence of these metabolic disorders presents a significant threat to public health worldwide, and treatment strategies that address the underlying pathological processes in liver are urgently needed. In the current proposal we will reveal novel physiological and molecular mechanisms of insulin sensitization with the goal of identifying novel strategies to target these metabolic diseases in the future.

PI_NAMEs: DEFRONZO, RALPH A;NORTON, LUKE  (contact)

PROJECT_TERMS: Acute;Address;Adipose tissue;Agonist;Antioxidants;Benign;Cardiolipins;Cell Nucleus;Cells;Chronic;Cirrhosis;Citric Acid Cycle;Clinical Trials;comorbidity;Coupled;Defense Mechanisms;density;design;Development;Disease;Disease Progression;Enzymes;Epidemic;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Fibrosis;Fostering;Future;Genomics;Glucose;glucose metabolism;Goals;Hepatic;hepatocellular injury;High Fat Diet;Human;human subject;in vivo;Inflammatory;innovation;insight;Insulin;Insulin Resistance;insulin sensitizing drugs;Knowledge;Life;lipidomics;Lipids;Liver;liver biopsy;Liver diseases;liver injury;Liver Mitochondria;liver transplantation;Mediating;Metabolic;Metabolic Diseases;Methodology;Mitochondria;mitochondrial metabolism;Molecular;Multiple Abnormalities;Mus;new epidemic;non-alcoholic fatty liver;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;novel strategies;novel therapeutics;Obesity;Outcome;oxidation;Oxidative Stress;Pathogenesis;Pathologic;Pathologic Processes;Pathway interactions;Patients;Peripheral;Phospholipids;Physiological;Pioglitazone;placebo controlled trial;Play;pleiotropism;PPAR gamma;preclinical study;Prevalence;Primary carcinoma of the liver cells;Propionates;Public Health;Publishing;pyruvate dehydrogenase kinase 4;response;Risk;Rodent;Role;Shotguns;single nucleus RNA-sequencing;stable isotope;Techniques;Testing;Therapeutic;therapeutic target;Tracer;transcriptomics;treatment strategy;uptake;Woman

PROJECT_TITLE: Targeting hepatic mitochondrial function in humans with NAFLD using insulin sensitizers

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Physical Activity;Prevention;Sleep Research;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Postpartum weight retention contributes to long term weight gain and obesity development in women. The purpose of this study is to develop a novel weight loss intervention that address diet, physical activity, and sleep in women during the postpartum period. This intervention has the potential to maximize the effects of prior interventions and improve maternal health.

PI_NAMEs: HAWKINS, MARQUIS S (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: acceptability and feasibility;Address;Age;Basic Science;Behavior;behavior change;Behavioral;behavioral health intervention;Behavioral Sciences;behavioral sleep intervention;Benchmarking;Body Weight decreased;Cardiovascular Diseases;career;Childbirth;circadian;Circadian Rhythms;Clinical Research;Conduct Clinical Trials;Control Groups;critical period;Development;diabetes prevention program;Diagnostic;Diet;diet and exercise;Disproportionately impacts women;Education;Effectiveness;efficacy testing;Elements;Energy Intake;Ensure;Epidemiology;exercise intervention;experience;feasibility testing;Feedback;Future;Goals;group intervention;Health behavior;Heterogeneity;improved;Individual;innovation;Internet;Intervention;intervention mapping;Interview;Learning;Life;Life Style;lifestyle intervention;lipid metabolism;Maternal Health;Measures;Medicine;Morbidity - disease rate;mortality;multidisciplinary;National Heart, Lung, and Blood Institute;novel;novel strategies;Obesity;obesity development;online intervention;online version;Overweight;Participant;perinatal period;Physical activity;pilot trial;poor sleep;post intervention;Postpartum Period;postpartum weight;Postpartum Women;prevent;Process;Randomized;Randomized, Controlled Trials;Reaction;recruit;reproductive;Research;Research Personnel;Risk;Risk Factors;Sampling;secondary outcome;Sleep;sleep behavior;Sleep Deprivation;Sleep Disorders;sleep health;sleep onset;Structure;Suggestion;Testing;therapy development;Thinking;Training;treatment strategy;user centered design;Weight;Weight Gain;weight loss intervention;Weight maintenance regimen;Woman

PROJECT_TITLE: Sleep GOALS - An Internet-Assisted Diet, Physical Activity, and Sleep Weight Loss Intervention for Postpartum Women

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Nanotechnology;Orphan Drug;Ovarian Cancer;Pancreatic Cancer;Precision Medicine;Radiation Oncology;Rare Diseases;Women's Health Research

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: NARRATIVE Advanced stage ovarian and pancreatic cancers with intrinsic or acquired resistance are considered incurable primarily due to the poor response rate of salvage chemotherapies, such as irinotecan and topotecan. The two main mechanisms that induce or promote chemoresistance are drug efflux mediated by ATP-binding cassette (ABC) transporters and DNA damage repair. This proposal will engineer the first light-activatable nanotechnology platform that combines photochemistry and drug repurposing strategies to selectively damage ABC transporters and inhibit DNA damage repair enzymes for improved outcomes.

PI_NAMEs: HUANG, HUANG CHIAO  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: ABCB1 gene;ABCG2 gene;Address;advanced pancreatic cancer;Animals;Antibiotic Therapy;Antibiotics;Antibodies;Antibody Therapy;ATP binding cassette transporter 1;ATP-Binding Cassette Transporters;Binding;Biodistribution;Biometry;blind;Cancer Biology;cancer cell;Cancer Model;Cancer Patient;cancer therapy;cell killing;Cell Proliferation;Chemoresistance;Chemosensitization;chemotherapy;Clinical;Clinical Trials;clinically relevant;Combined Modality Therapy;Complex;cytotoxic;density;Development;Diffusion;DNA;DNA Repair;DNA Repair Enzymes;dosimetry;driving force;Drug Delivery Systems;Drug Efflux;Drug Kinetics;drug repurposing;Drug resistance;Engineering;Epidermal Growth Factor Receptor;Extravasation;Fluorescence;fluorescence imaging;Goals;Human;Image;image guided;imaging capabilities;imaging system;improved;improved outcome;in vivo;individual patient;inhibitor;intraperitoneal;irinotecan;Knowledge;Ligation;Light;light dosimetry;liposomal formulation;Liposomes;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Mediating;Medical Oncology;microendoscope;Minocycline;Modality;Modification;Molecular Profiling;Monitor;mortality;mouse model;multidisciplinary;nanoscale;Nanotechnology;nanotechnology platform;Neoplasm Metastasis;Normal tissue morphology;novel;Operative Surgical Procedures;ovarian neoplasm;pancreatic cancer cells;pancreatic cancer model;pancreatic neoplasm;patient derived xenograft model;patient prognosis;Patients;Pharmaceutical Preparations;Photochemistry;Photosensitizing Agents;Play;predictive marker;Pump;Regimen;Regulation;repair enzyme;Resistance;response;Role;Safety;safety assessment;spatiotemporal;Surface;Surgical Oncology;synergism;targeted treatment;Technology;Tetracyclines;Therapeutic;Tissues;Topoisomerase-I Inhibitor;Topotecan;Toxic effect;Treatment Efficacy;Treatment outcome;tumor;Tumor Debulking;tumor microenvironment;Type I DNA Topoisomerases;tyrosyl-DNA phosphodiesterase;Unresectable;Up-Regulation

PROJECT_TITLE: Addressing Chemoresistance in Pancreatic and Ovarian Cancers: Photodynamic Priming and Repurposing of Tetracyclines using Targeted Photo-Activable Multi-Inhibitor Liposome

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Gene Therapy;Genetics;Nanotechnology;Prostate Cancer;Urologic Diseases

ORG_CITY: EDINBURG

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

PHR: Tumor suppressor microRNAs (miRNAs, in this case miR-205) extends the ability to turn off specific genes or pathways associated to cancer cell survival, metastasis and drug resistance, however, efficient delivery to tumors is hampered to due to stability and toxicity issues. Therefore, we propose to use a dual layered magnetic nanoplatform of miR-205 to CRPC tumors which can significantly improve tumor treatment, lower drug resistance and recurrence. In addition, this SCORE Program SC01 application will promote the research competitiveness of Dr. Yallapu at the University of Texas Rio Grande Valley (UTRGV), which has focused on training and graduating students from backgrounds nationally underrepresented in biomedical research.

PI_NAMEs: YALLAPU, MURALI MOHAN (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Address;Affect;androgen independent prostate cancer;anti-cancer research;Antigen Targeting;Apoptotic;Award;beta Tubulin;Biodistribution;Biological;Biological Assay;Biological Availability;biomaterial compatibility;Biomedical Research;Blood;cancer cell;Cell Survival;Cells;Characteristics;Chemoresistance;Chemosensitization;chemotherapy;Clinic;Clinical;Clinical Oncology;Complex;contrast enhanced;cost effective;cost efficient;Data;Development;docetaxel;Down-Regulation;Drug resistance;efficacy evaluation;Environment;Epigenetic Process;epithelial to mesenchymal transition;Epithelium;FDA approved;Flow Cytometry;Fluorescence;FOLH1 gene;Formulation;Gel;Genes;graduate student;Growth;Human;Immunology;improved;In Vitro;in vivo;Investigation;Link;Literature;Magnetic nanoparticles;Magnetic Resonance Imaging;Magnetism;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;medical schools;men;Methods;Microbiology;microRNA delivery;MicroRNAs;mid-career faculty;Mission;Molecular;mouse model;nanoparticle;nanotechnology platform;Neoplasm Metastasis;neovasculature;Normal tissue morphology;novel;Oncogenic;Outcome;particle;Particle Size;Pathway interactions;patient derived xenograft model;PIK3CG gene;preclinical study;Productivity;programs;Prostate;prostate cancer cell;prostate cancer cell line;prostate cancer progression;Publications;Recurrence;Regulation;Replacement Therapy;Research;Research Activity;Research Support;Resistance;resistance mechanism;restoration;Risk;Role;Safety;Science;self assembly;Shapes;Signal Pathway;Site;Stream;Surface;System;systemic toxicity;targeted treatment;Texas;theranostics;Therapeutic;therapeutic miRNA;therapeutic nanoparticles;therapy outcome;Time;Tissues;Toxic effect;Training;Treatment Efficacy;tumor;Tumor Suppressor Proteins;Tumor Tissue;tumorigenesis;undergraduate student;United States National Institutes of Health;Universities;uptake;Virus;Western Blotting;Work;Xenograft procedure;zeta potential

PROJECT_TITLE: miR-205 Nanoparticle system circumvents docetaxel resistance in prostate cancer


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative: The proposed research will define the cellular biology of the oxysterol-binding protein (OSBP) in viral proliferation. OSBP has been identified as a critical mediator in the replication of RNA pathogenic viruses, including coronaviruses. These viruses are a major cause of human sickness and mortality, and therefore the proposed research is relevant to public health and relevant to the NIH's mission of reducing illness and disability.

PI_NAMEs: BURGETT, ANTHONY WG (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: 2019-nCoV;Alternative Splicing;Anti-viral Response;antiviral drug development;antiviral immunity;Autophagocytosis;Biological;Biology;Cell Physiology;Cells;Cellular biology;Chemicals;cholesterol-binding protein;Complex;Coronavirus;Coronavirus Infections;COVID-19 pandemic;Dengue Virus;design;disability;Disease;Dose;drug development;Drug Targeting;Enterovirus;Eukaryotic Cell;Family;Family Picornaviridae;Flavivirus;Foundations;Future;Generations;Goals;Hepatitis C;Human;human pathogen;Individual;Infection;Innate Immune Response;insight;Lipids;Mediating;Mediator;Membrane;Messenger RNA;Mission;Modality;Modeling;Morphology;mortality;nanomolar;Nonsense-Mediated Decay;novel virus;oxysterol binding protein;pathogenic virus;Pathogenicity;Pathway interactions;Process;Program Development;Proliferating;prophylactic;protein function;Proteins;Public Health;Publications;Publishing;Reporting;Repression;Research;response;Rhinovirus;RNA;RNA replication;RNA Viruses;Role;sensor;small molecule;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic lead compound;Translations;United States National Institutes of Health;Viral;Viral Physiology;Viral Proteins;Virus;Virus Diseases;Virus Replication;Work;Zika Virus

PROJECT_TITLE: Cellular Mechanism of Oxysterol-Binding Protein (OSBP) in Viral Proliferation: A Chemical Biology Approach

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence

ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: Positron emission tomography (PET) imaging is a non-invasive molecular imaging technique that allows real-time in vivo monitoring of physiological processes via administration of a radiotracer (a molecule tagged with a PET radioisotope) to a patient. Currently, PET imaging finds application in drug discovery, disease diagnosis and monitoring, and personalized medicine. Approximately 2 million PET scans are conducted annually, and there is significant room for further growth. However, the impact of PET cannot be fully realized without both new synthetic methods for the assembly of radiotracers as well as the translation of these synthesis methods to routine clinical production. The overall objective of our research is to develop new chemistry for preparing currently inaccessible PET radiotracers, use machine learning techniques to optimize production yields with these new methods, and introduce automated cassette technology that will allow easy and confident use of this new chemistry to produce PET radiotracers for clinical trials and routine standard of care.

PI_NAMEs: SANFORD, MELANIE S.;SCOTT, PETER JAMES HENRY (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acceleration;Address;Adoption;aryl halide;Automation;Award;Basic Science;Caring;Catalysis;Chemistry;Clinical;clinical application;Clinical Trials;Collaborations;Copper;cost;Data;Data Set;design;Development;disease diagnosis;disorder prevention;Dose;drug discovery;drug-like compound;Electrons;Emission-Computed Tomography;FDA approved;Fluorides;Fluorine;Generations;Goals;Good Manufacturing Process;Grant;Growth;Hydrogen Bonding;imaging agent;imaging detection;Imaging Techniques;improved;in vivo monitoring;innovation;Label;Machine Learning;machine learning algorithm;Manuals;manufacturing capabilities;Mediating;Mediator;Medical;method development;Methods;Modeling;molecular imaging;Monitor;morpholine;Multi-Institutional Clinical Trial;neural network;Nuclear;Paper;Patients;Pattern;Performance;personalized medicine;Pharmacy facility;Physiological Processes;Play;Positioning Attribute;Positron-Emission Tomography;preclinical imaging;predictive modeling;Process;Production;Publishing;pyridine;Radiochemistry;Radioisotopes;Radiolabeled;radiotracer;random forest;Reaction;Reporting;Reproducibility;Research;scaffold;Side;Site;standard of care;success;Techniques;Technology;Time;Transition Elements;Translating;Translations;Validation

PROJECT_TITLE: Copper-mediated Radiofluorination: from Proof-of-Concept to Clinical Impact

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative – Relevance to Public health Heart failure remains a leading cause of mortality in the United States. The underlying molecular mechanisms of pathological cardiac remodeling and dysfunction in heart failure are not fully understood. Our goal is to advance our understanding of the molecular and cellular bases of heart failure, which may lead to the identification of novel therapeutic targets and strategies for treating heart failure. This project is to elucidate the functions and underlying mechanisms of dysregulating cyclic nucleotide phosphodiesterase 10A (PDE10A) expression in pathological cardiac remodeling and dysfunction, particularly from the perspective of revealing the therapeutic potential of PDE10A inhibition in pharmacological intervention of cardiac disorders. Given the clinical trials of PDE10A inhibitors for schizophrenia and Huntington’s disease, PDE10A has been proven to be a safe drug target.

PI_NAMEs: YAN, CHEN  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Ablation;Adenosine;ADORA2A gene;Agonist;Antipsychotic Agents;ARRB2;Attenuated;attenuation;base;Biological Process;Biology;Brain;Cardiac;Cardiovascular system;Cell model;Cell-Free System;Cells;Cessation of life;Clinical Trials;Corpus striatum structure;Couples;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Cyclic Nucleotides;Data;Development;Dimerization;Disease;Dopamine Receptor;Dose;DRD2 gene;drug metabolism;Drug Targeting;Enzymes;Fibrosis;Functional disorder;G-Protein-Coupled Receptors;Genes;Genetic;Goals;HDAC5 gene;Heart;Heart Diseases;Heart failure;Heart Injuries;Heterodimerization;Homeostasis;Human;Huntington Disease;Hypertrophy;In Vitro;in vivo;inhibitor;insight;Intervention;ischemic injury;Isoenzymes;Knock-out;Knockout Mice;Mediating;Molecular;mortality;Multiprotein Complexes;Mus;Muscle Cells;Muscle Contraction;myocardial damage;Myocardial Infarction;Myocardial Ischemia;Nervous System Disorder;Nervous System Physiology;Neurons;new therapeutic target;novel;novel drug combination;novel therapeutic intervention;Nuclear Import;nucleotide metabolism;overexpression;Pathologic;Pathologic Processes;Peripheral;pharmacologic;Pharmacotherapy;phosphoric diester hydrolase;Phosphorylation;Physiological;Play;pressure;protective effect;Protein Isoforms;Protein Phosphatase 2A Regulatory Subunit PR53;Public Health;Reaction;receptor;recruit;Regulation;Relaxation;Reporting;Role;Schizophrenia;Second Messenger Systems;side effect;Signal Pathway;Signal Transduction;Signaling Molecule;Source;Specificity;Stimulus;System;Testing;Therapeutic;Tissues;tool;United States;ventricular hypertrophy

PROJECT_TITLE: Regulation and Function of Cyclic Nucleotide Phosphodiesterase in Cardiac Biology and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MIM-R(01)]


NIH_SPENDING_CATS: Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Infectious Diseases;Liver Disease;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

PHR: PROJECT NARRATIVE Schistosomiasis is a helminth or worm infection prevalent in many countries globally that can cause significant scarring of the liver. This study will use blood samples to identify “biomarkers” that predict the risk of worsening of this scarring over time so that these individuals may receive treatment earlier.

PI_NAMEs: FRIEDMAN, JENNIFER F (contact);JIZ, MARIO ANTONIO II LARIDA

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Address;Age;Animal Model;Antigens;Area;Area Under Curve;Biological Assay;Biological Markers;biomarker identification;Blood specimen;Case Fatality Rates;Cessation of life;chemotherapy;Cicatrix;Compensation;Country;Death Rate;Deposition;Development;Diagnostic tests;Early identification;Early treatment;egg;equipment acquisition;Esophageal Varix;Evaluation;Exclusion;Fibrosis;Funding Opportunities;Future;Gastroenterology;Goals;Grant;Guidelines;Helminths;Hemorrhage;high risk;high risk population;Human;Individual;Infection;inhibitor;Intervention;Intestines;intrahepatic;Lateral;Liver;Liver Fibrosis;low and middle-income countries;manufacturing capabilities;Metalloproteases;Morbidity - disease rate;novel marker;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Philippines;point of care testing;Portal Hypertension;Praziquantel;Preventive treatment;Process;Production;progression risk;Protocols documentation;Pulmonary Fibrosis;Randomized, Controlled Trials;Recommendation;recruit;Research;research clinical testing;Research Institute;Research Personnel;response;Risk;Risk Factors;risk mitigation;risk prediction;Rupture;Schistosoma;Schistosoma japonicum;Schistosomiasis;screening;Secondary to;Serum;specific biomarkers;surgical risk;synthetic polymer Bioplex;Time;Tissues;treatment strategy;Tropical Medicine;Ultrasonography;ultrasound

PROJECT_TITLE: Biomarkers to Identify Individuals at RIsk for Progression of S. Japonicum Associated Hepatic Fibrosis with Point of Care Test Development


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative A central question in dementias including in Alzheimer's disease (AD), Lewy body dementia (LBD) and frontotemporal dementia (FTD) is how synapse loss occurs and whether (and if so, how) synaptic and memory loss can be attenuated or halted. This effort seeks to uncover the role of αSyn on tau expression, tau aggregation, tau deposition and tau-mediated cognitive impairment. We will be using a series of genetic approaches to assess whether constitutive or conditional ablation of the SNCA gene encoding αSyn modulates human tau expression, alleviates tau pathology and tau-induced cognitive deficits in a model of tauopathy.

PI_NAMEs: LEE, MICHAEL K (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Ablation;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Attenuated;Autophagocytosis;Biology;Cell Culture System;Chronic;Clinical;Cognitive;Cognitive deficits;cognitive function;conditional knockout;Coupling;Data;Defect;Degradation Pathway;delivery vehicle;Dementia;Deposition;design;Disease Progression;endoplasmic reticulum stress;excitatory neuron;Frontotemporal Dementia;genetic approach;Human;hyperphosphorylated tau;Impaired cognition;in vivo;Knowledge;Lewy Body Dementia;Link;Mediating;Memory impairment;Memory Loss;Modeling;mouse model;multicatalytic endopeptidase complex;Mus;Neurons;neuropathology;novel;Onset of illness;overexpression;Parkinson Disease;Pathologic;Pathology;Pathway interactions;PHF-1;pre-clinical;prevent;Prosencephalon;protein degradation;Protein Isoforms;Proteins;Regulation;Reporting;Role;Series;SNCA gene;Surveys;Synapses;synaptic function;Synaptic Vesicles;Syndrome;synuclein;System;tau aggregation;tau expression;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;therapeutic evaluation;Transgenic Mice;Ubiquitin;Viral Vector;Wild Type Mouse;β-amyloid burden

PROJECT_TITLE: Regulation of human tau expression and tauopathy by alpha-synuclein


NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Prostate Cancer;Urologic Diseases;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Breast and prostate tumors are dependent for growth on estrogen receptor or androgen receptor respectively and harbor mutations in the PI3K pathway. As such, they are treated with endocrine therapies and PI3K inhibitors but the clinical benefit to these therapies in limited by the emergence of drug resistance. In this proposal we are studying the molecular mechanisms of the epigenetic regulators KMT2D and SMYD2 in the regulation of nuclear receptor function and treatment outcome with the goal of designing and developing improved therapeutic strategies for these patients.

PI_NAMEs: TOSKA, ENEDA  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Ablation;advanced prostate cancer;Affect;AKT inhibition;AKT1 gene;Androgen Antagonists;Androgen Receptor;Androgens;anti-cancer research;Anti-estrogen Therapy;Breast;Breast Cancer cell line;Breast Cancer Model;cancer cell;Cancer Etiology;Cancer Patient;Cell Differentiation process;Cells;Chromatin;Clinical;cofactor;Combined Modality Therapy;Computational Biology;Data;design;Diagnosis;DNA Sequence Alteration;Drug resistance;Enhancers;Environment;Epigenetic Process;epigenetic therapy;epigenomics;Estrogen Nuclear Receptor;Estrogen Receptors;Estrogens;Genes;genetic manipulation;Genetic Transcription;Goals;Growth;histone methyltransferase;Hormone Receptor;hormone therapy;Hormones;improved;inhibitor;Lysine;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mammary Neoplasms;Mediating;men;Methylation;Methyltransferase;Modeling;Molecular;multidisciplinary;mutant;Mutation;novel;Nuclear Hormone Receptors;Nuclear Receptors;Organoids;Pathway interactions;patient population;Patients;pharmacologic;Phosphorylation;PI3K/AKT;PIK3CA gene;PIK3CG gene;Play;pre-clinical;Prostate;prostate cancer cell;prostate cancer model;Prostatic Neoplasms;Protein Methylation;Publishing;Reagent;receptor function;Receptor Signaling;recruit;Regulation;Reporting;research clinical testing;Resistance;Resources;response;Role;Science;Serine;Signal Pathway;single cell sequencing;Site;Therapeutic;Therapeutic Studies;transcription factor;Treatment outcome;treatment response;tumor;tumor growth;tumorigenesis;United States;Women's mortality

PROJECT_TITLE: Mechanisms by which histone methyltransferases regulate nuclear receptor activity and response to therapy in hormone-driven tumors.

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Immunization;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Vaccine Related

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative In this interdisciplinary project, we will use cell- and tissue-specific galectin-3 loss- and gain-of-function mouse models to determine the causative effects and the mechanisms mediated by galectin-3 in cardiac fibrosis and myocardial dysfunction after repetitive exposure to ionizing radiation. In addition, we will test the efficacy of a new galectin-3 inhibitor vaccine in preventing radiation-induced cardiotoxicity.

PI_NAMEs: SHARMA, UMESH C (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Acceleration;Address;Affinity;Algorithms;Attenuated;Binding;Biological Markers;Blood;Bone Marrow Purging;Bone Marrow Transplantation;Cancer Patient;Carbohydrates;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;cardioprotection;Cardiotoxicity;Cell Communication;Cell Surface Receptors;Cells;Cessation of life;Chest;Clinical Research;Collagen;coronary fibrosis;Cyclin D1;Data;design;Development;Dose;Early identification;efficacy testing;Engraftment;Experimental Designs;Exposure to;Fibroblasts;fibrogenesis;Fibrosis;Functional disorder;gain of function;Galectin 3;Genes;Genetic;Genetic Engineering;Goals;Growth;Half-Life;Heart;heart damage;Heart failure;heart function;Immunization;Immunomodulators;immunoregulation;In Vitro;Inflammation;Inflammatory;inhibiting antibody;inhibitor;Intervention;Intramuscular;Ionizing radiation;irradiation;Knock-out;Knockout Mice;Laboratories;loss of function;Macrophage;Malignant neoplasm of thorax;MAPK8 gene;mast cell;Measures;Mediating;Mediator;Modeling;mouse model;Mus;Muscle Cells;Myocardial;Myocardial dysfunction;Myocarditis;Myocardium;neutralizing vaccine;novel therapeutics;novel vaccines;Outcome;overexpression;paracrine;Pathway interactions;Patients;Peptides;pre-clinical;preclinical study;Predisposition;prevent;Preventive;Process;Proliferating;Property;protective effect;Publishing;Pulmonary Fibrosis;Radiation;radiation effect;Radiation exposure;Radiation therapy;receptor;Recombinant Proteins;Reporting;response;Risk;stem cells;Surface;System;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;Therapeutic Studies;Tissues;Transforming Growth Factors;Transgenic Organisms;United States Food and Drug Administration;Vaccine Adjuvant;Vaccines;Work

PROJECT_TITLE: Immunomodulation of Galectin-3 to Prevent Radiation-Induced Myocardial Fibrogenesis

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE The SIM-STI Program aims to develop an innovative biomimetic model of the lower reproductive tract to study aspects of the sexually transmitted infections (STIs), chlamydia and gonorrhea, that are not achievable in humans or with current animal or cell models. The ultimate impact of this research will be to improve public health by reducing the incidence of STIs in humans. Therefore, it is relevant to the field of public health and to the mission of the NIH, in that it seeks to improve women’s well-being by generating critical research, pre-clinical tools and additional knowledge, both fundamental and action-oriented.

PI_NAMEs: BAVOIL, PATRIK M;GLEGHORN, JASON PAUL;RAVEL, JACQUES  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: 3-Dimensional;Address;Animal Model;Animals;Biological Models;Biomimetics;Cell Culture Techniques;Cell model;Cells;Cervical;cervicovaginal;Chlamydia;Chlamydia trachomatis;Chronic Disease;Clinical;co-infection;Collaborations;Communicable Diseases;Data;Disease;Disease Outcome;Ectopic Pregnancy;Endothelial Cells;Engineering;Environment;Epithelial Cells;Epithelium;Estradiol;Ethics;Evaluation;experimental study;Exposure to;Failure;Fibroblasts;Genetic Transcription;Gonadal Steroid Hormones;Gonorrhea;Homeostasis;Hormonal;Human;human tissue;Immune;Immune response;Immunity;Immunologics;improved;Incidence;Infection;innovation;Knowledge;Life;Menstrual cycle;Metabolic;Methodology;Microbe;microbial;microbiome;microbiota;microbiota composition;Mission;model design;Modeling;Molecular;Mucous body substance;Mucous Membrane;Nature;Neisseria gonorrhoeae;novel;Outcome;pathogen;Pathogenesis;Pelvic Inflammatory Disease;permissiveness;Personal Satisfaction;Phase;pre-clinical;Predisposition;prevent;Preventive;Progesterone;programs;Public Health;reproductive tract;Research;Resistance to infection;Resources;response;Role;Severity of illness;Sexually Transmitted Diseases;Site;Structure;success;Symptoms;Testing;Therapeutic;Tight Junctions;Time;Tissues;tool;tubal infertility;United States National Institutes of Health;Virulence Factors;Woman

PROJECT_TITLE: Structure, immunity and microbiome: Human 3D biomimetics cervicovaginal models for sexually transmitted infections (SIM-STI)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Women's Health Research

PI_NAMEs: RAVEL, JACQUES  (contact)

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Back;Baltimore;Biological Response Modifier Therapy;Biomimetics;Budgets;cervicovaginal;Chlamydia trachomatis;Clinical;Collaborations;college;Communication;Communities;Complex;Coordination and Collaboration;Data;Data Analyses;data dissemination;data integration;data sharing;Delaware;Engineering;Ensure;Environment;experience;Financial Support;Fostering;genome sciences;Goals;Grant;Group Meetings;Human;Immunity;improved;Individual;Infection;innovation;Institution;Intellectual Property;Knowledge;Leadership;lectures;Maryland;medical schools;meetings;microbiome;microbiota;Modeling;Neisseria gonorrhoeae;Outcome;outreach;Pharmaceutical Preparations;Policies;preclinical study;Principal Investigator;programs;Progress Reports;Reporting;Research;Research Activity;research and development;Research Personnel;Research Project Grants;Resolution;Resources;Running;Schedule;School Dentistry;Scientist;Sexually Transmitted Diseases;Structure;Subgroup;symposium;Technology;Teleconferences;Training;United States National Institutes of Health;Universities;Women's Health;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Stroke

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative The blood vessels in our brains form a complicated three-dimensional network that varies from person to person. Neurosurgeons need a roadmap of this vascular network to effectively treat neurovascular disease, which can cause devastating and life-threatening injury to the brain. We are developing ways to create patient-specific models of neuro-vasculature that show how blood moves to different parts of the brain, and software that allows surgeons to interactively explore these models to enable safer and more effective treatment of these diseases.

PI_NAMEs: FRISKEN, SARAH  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;Affect;Algorithms;American;Aneurysm;Angiography;annotation  system;Architecture;Area;Arteriovenous fistula;Arteriovenous malformation;Blood;Blood flow;Blood Vessels;Bolus Infusion;Brain;Brain Death;Brain Edema;Brain Injuries;Brain Neoplasms;cerebrovascular;Cerebrovascular Disorders;cerebrovascular surgery;Cerebrovascular system;Clinical;Communities;Complex;Computer Assisted;Computer software;Contrast Media;Data;Diameter;digital;Digital Subtraction Angiography;Disease;effective therapy;Effectiveness;Exposure to;Generations;Goals;Hemorrhage;Image;image processing;imaging modality;improved;Individual;Injury;interactive visualization;Intraoperative Monitoring;Ionizing radiation;Life;Machine Learning;machine learning method;Magnetic Resonance Angiography;Manuals;Measures;Medical Imaging;Methods;Modeling;Monitor;Movement;Neurosurgeon;neurovascular;novel;novel strategies;open source;Operative Surgical Procedures;Patients;Persons;Phase;Population;Probability;prototype;reconstruction;Research;Resolution;Risk;Rupture;Safety;simulation;software systems;Stroke;Surgeon;System;technology validation;temporal measurement;Testing;three dimensional structure;Three-Dimensional Imaging;three-dimensional visualization;Time;tool;Training;Trees;Uncertainty;usability;vector;Venous;virtual;Visualization;Visualization software;white matter;Work;X-Ray Computed Tomography

PROJECT_TITLE: Generating High Quality, High Resolution, Patient-Specific 4D Models of Cerebral Vasculature

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE This study aims to assess the availability of the alpha7 nicotinic acetylcholine receptor (α7-nAChR) in patients with mild cognitive impairment (MCI). This project will use positron emission tomography and [18F]ASEM, a new radiotracer developed to image the α7-nAChR, in brains of patients with MCI and cognitively normal individuals, the latter serving as a comparison group. We will also assess the relationships between the α7- nAChR in the brain and 1) cognitive performance and 2) circulating autoantibodies to the α7-nAChR and other biofluid markers at baseline and 2-year follow-up.

PI_NAMEs: BAKKER, ARNOLD ;COUGHLIN, JENNIFER MARIE (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta accumulation;Affinity;Age;alpha-bungarotoxin receptor;Alzheimer's Disease;Amyloid beta-42;Amyloid beta-Protein;apolipoprotein E-4;Autoantibodies;basal forebrain;Binding;Biological;Biological Markers;Blood;Brain;Brain region;carrier status;Cell Death;Cell surface;Cells;Cerebrospinal Fluid;Cerebrum;cholinergic;cholinergic neuron;Cognition;Cognitive;cognitive control;cognitive performance;cognitive testing;comparison control;comparison group;Complex;Control Groups;Cytolysis;Data;Data Collection;Dementia;Diagnosis;Diagnostic;disability;Disease;DNA;Elderly;experience;extracellular;follow-up;Functional disorder;Goals;Image;imaging biomarker;Immune Plasma;Immunologic Markers;Impaired cognition;in vivo;in vivo imaging;Individual;Individual Differences;inflammatory marker;Link;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Microglia;mild cognitive impairment;Morbidity - disease rate;neocortical;neuroimaging;Neurons;non-smoking;normal aging;Occipital lobe;Parietal Lobe;Participant;Pathology;Patients;Plasma;Population;Positron-Emission Tomography;Protein Microchips;Publishing;radiotracer;receptor binding;Research;Risk;Risk Factors;Senile Plaques;sex;Staging;Synapses;tau Proteins;tau-1;Testing;Therapeutic;Work

PROJECT_TITLE: Imaging the alpha7 nicotinic acetylcholine receptor in mild cognitive impairment

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Drug Abuse (NIDA only);Health Services;Heart Disease;Infectious Diseases;Patient Safety;Rare Diseases;Substance Misuse

PHR: PROJECT NARRATIVE The opioid epidemic has been associated with a sharp increase in hospitalizations for drug use-associated infective endocarditis (DUA-IE), a severe infection of the heart valves resulting from injecting drugs. Little is known regarding long-term outcomes following DUA-IE or about patients’ knowledge and preferences surrounding addiction treatment in this setting. This proposed research aims to address these fundamental gaps in knowledge, generating foundational data that can help inform treatment protocols as well as individual and structural interventions to improve DUA-IE patients’ outcomes.

PI_NAMEs: SCHRANZ, ASHER JACOB (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Accounting;addiction;Address;adverse outcome;Antibiotic Therapy;Antibiotics;Area;Award;Behavioral;behavioral health;Cardiac Surgery procedures;career;Caring;Clinical;Communicable Diseases;Data;Data Set;Death Records;Demographic Factors;Development;Disease;Drug Metabolic Detoxication;Drug usage;Drug Use Disorder;Education;Emergency Situation;Endocarditis;Epidemiologist;Epidemiology;Evaluation;experience;Fostering;Foundations;Funding;Future;future implementation;Goals;Health Services Accessibility;Health Services Research;heart damage;heart valve replacement;Heart Valves;high risk;Hospital Charges;Hospital Costs;hospital readmission;Hospital Referrals;Hospitalization;Hospitals;Human Subject Research;improved;Incidence;Individual;Infection;Infectious Diseases Research;Infective endocarditis;injection drug use;Injections;Inpatients;Instruction;Insurance;Intervention;Interview;Intravenous;Knowledge;Length of Stay;Life;Link;Medicaid;medical complication;Mentors;Mentorship;Morbidity - disease rate;mortality;North Carolina;novel;Operative Surgical Procedures;opioid epidemic;Outcome;Overdose;patient safety;Patient-Focused Outcomes;Patients;Perception;Pharmaceutical Preparations;Population;preference;prevent;Public Health;Qualitative Research;Questionnaires;Recurrence;Relapse;Repeat Surgery;Research;Research Personnel;Resources;response;Risk;Risk Factors;Role;Scientist;Site;skill acquisition;skills;Structure;Surveys;System;Training;treatment guidelines;Treatment Protocols;Uninsured;Universities;Visit;Work

PROJECT_TITLE: Drug-use associated infective endocarditis: Post-hospitalization outcomes and patient treatment preferences

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: In humans, accumulating evidence links mutations in a number of core ribosome components and in particular ribosomal proteins (RPs) to congenital birth defects, including Diamond-Blackfan anemia (DBA) characterized by specific congenital birth defects including limb abnormalities, cleft palate, growth failure, as well as bone marrow failure. In all of these cases, the mechanism(s) that would account for these cell and tissue specific phenotypes remain poorly understood. Defining at a more basic level the specificity and dynamics of ribosome-mediated control gene regulation will be invaluable for our understanding of how deregulations in the ribosome alter accurate control of gene expression underlying human congenital birth defects.

PI_NAMEs: BARNA, MARIA  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: 5' Untranslated Regions;Area;Atlases;Attention;Biological;Biology;Bone marrow failure;Cell Differentiation process;Cell Lineage;cell type;Cells;Cellular biology;Cleft Palate;Code;Complex;Congenital Abnormality;Cytoplasm;Data;Development;Developmental Biology;Developmental Gene;Diamond-Blackfan anemia;Disease;Elements;Embryo;Embryonic Development;embryonic stem cell;Endoderm;Endoderm Cell;Endowment;Enhancers;Epithelial Cells;Failure;Fibroblast Growth Factor;field study;frontier;Gene Expression;Gene Expression Regulation;gene regulatory network;Genetic;genetic approach;Genetic Transcription;genome-wide;genome-wide analysis;Growth;Heterogeneity;Human;human embryonic stem cell;in vivo;Individual;interdisciplinary approach;Lactation;Life;Limb structure;Link;mammalian genome;mammary;mammary gland development;MAP Kinase Gene;Mediating;Mesoderm;Mesoderm Cell;Messenger RNA;Milk Proteins;Molecular Machines;mRNA Translation;Mus;Mutation;neonate;new technology;novel;Organelles;paralogous gene;Paraxial Mesoderm;Pathway interactions;Pattern;Phenotype;PIK3CG gene;Play;Population;postnatal development;posttranscriptional;preference;Pregnancy;Process;Production;progenitor;programs;Protein Isoforms;Proteins;Pseudogenes;Regulation;Regulon;Research;Ribosomal Proteins;Ribosomes;ribosomopathy;RNA Splicing;Role;RPS27 gene;sequencing platform;SHH gene;Signal Pathway;Signal Transduction;spatiotemporal;Specific qualifier value;Specificity;stem cell biology;stem cell differentiation;stem cells;Subcellular Spaces;System;Time;Tissues;tool;Translating;Translational Regulation;Translations;Variant;WNT Signaling Pathway;Work

PROJECT_TITLE: Specialized Translational Control of Stem Cell Differentiation and Embryonic Development

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]