PHR: PROJECT NARRATIVE Sepsis is a complex clinical infectious disease that represents one of the leading causes of death across the world. Decades of research have failed to produce new clinically efficacious treatments, mandating the development of novel strategies to prevent and treat infection. The design of such strategies necessitates that we obtain a clear understanding of the mechanisms by which diverse human pathogens injure the endothelium causing lethal disease, which forms the focus of this proposal.

PI_NAMEs: ALFANO, DANIELLE NICOLE (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: alpha Toxin;Anatomy;Animal Disease Models;Antibiotics;Basic Science;Binding;Biological;Biology;Blood Platelets;Blood Vessels;cadherin 5;Candida albicans;career;career development;Cause of Death;CD44 gene;cecal ligation puncture;Cell membrane;Cell Physiology;Cessation of life;Clinical;Communicable Diseases;Complement;Complex;Data;Dependence;design;Development;Disease;Disintegrins;DTR gene;efficacious treatment;Elements;Endothelial Cells;endothelial-specific sialomucin;Endothelium;Ensure;Environment;Event;Faculty;Functional disorder;Funding;Future;Genetic Polymorphism;Goals;Homeostasis;Hospital Costs;Human;human pathogen;Immune response;Immunology;In Vitro;in vivo;in vivo imaging;Infection;Inflammatory;Injury;insight;Invaded;IV Fluid;K-Series Research Career Programs;Knock-out;Knockout Mice;Knowledge;Laboratory Study;Learning;Life;Lipopolysaccharides;Magic;Mediating;Mediator;member;Mentors;Metalloproteases;Modeling;Molecular;mortality;mouse model;multiorgan damage;Mus;Nature;notch protein;novel;novel strategies;novel therapeutics;Organ;organ injury;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Physicians;Physiological;Play;Population;pre-clinical research;prevent;promoter;Proteomics;Pseudomonas aeruginosa;Public Health;receptor;Recording of previous events;Research;Research Personnel;Resolution;Risk;Role;Scientist;sensor;Sepsis;septic;Septic Shock;Signal Pathway;Signal Transduction;skills;Staphylococcus aureus;Streptococcus Group B;Streptococcus pneumoniae;Supportive care;Syndrome;Systemic infection;Therapeutic;therapeutic development;Thrombosis;Thrombus;Tissues;TNF gene;Toxin;Training;Translating;Translational Research;Treatment Failure;Up-Regulation;Vascular Endothelial Growth Factors;Vascular Endothelium;Virulence

PROJECT_TITLE: ADAM10 as a molecular specifier of sepsis

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: LOUISVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Disruption of DNA double-strand break (DSB) repair promotes triple negative breast cancer (TNBC). The overarching goal of this study is to determine the molecular mechanisms responsible for disruption of DSB repair elicited by cadmium (Cd) exposure to promote TNBC. These studies will elucidate a fundamental mechanism not currently recognized that can explain TNBC disparities.

PI_NAMEs: NAIL, ALEXANDRA NICHOLE (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Affect;aggressive breast cancer;Anchorage-Independent Growth;Area;ataxia telangiectasia mutated protein;base editing;Binding;Biological;Biological Assay;Biophysics;Black race;black women;brca gene;BRCA mutations;BRCA1 gene;Breast;Breast Cancer gene;Breast Cancer Risk Factor;breast cancer survival;Breast Epithelial Cells;Cadmium;cancer health disparity;cancer initiation;carcinogenesis;Carcinogens;career development;Cell Separation;Cells;Chronic;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;Cysteine;Data;Death Rate;Development;DNA;DNA Adducts;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Environmental Exposure;Environmental Health;epidemiology study;experimental study;Exposure to;fusion gene;Gene Deletion;Gene Fusion;Gene Mutation;Genetic;Germ Lines;Germ-Line Mutation;Goals;Grant;Half-Life;Heavy Metals;high risk;Hispanic Women;homologous recombination;Housing;Human;Human body;Immunocompromised Host;In Vitro;Incidence;Individual;Industrialization;innovation;Lateral;lectures;Link;Malignant - descriptor;Malignant Breast Neoplasm;mammary;Mass Spectrum Analysis;Measures;Mediating;Mentors;Metal exposure;meter;Methods;Mind;Modeling;Molecular;molecular imaging;Mus;Mutation;mutation carrier;next generation sequencing;Nonhomologous DNA End Joining;Not Hispanic or Latino;Nuclear;overexpression;Pathway interactions;Peptides;Phase;Phosphotransferases;Population;Prevalence;programs;protein function;Proteins;Publications;Recombinant DNA;Recombinant Proteins;recombinational repair;repaired;Research;research and development;residential segregation;Resource Development;Rest;Role;Series;Signal Transduction;single molecule;Sister Chromatid Exchange;Site;skill acquisition;superfund site;targeted treatment;Technical Expertise;Testing;Tissues;Training;triple-negative invasive breast carcinoma;tumor;tumor progression;tumorigenic;United States National Institutes of Health;Universities;White Women;Writing;Zinc;Zinc Fingers

PROJECT_TITLE: Unraveling the molecular link between heavy metal exposure and triple negative breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-W (K9)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: NARRATIVE The research in this proposal aims to uncover the mechanisms underlying heterogeneity in complex diseases through the identification of: (i) the context (tissues, cell types, gene networks) in which causal genes operate, and (ii) shared and distinct genetic risk profiles among patients. This knowledge will be integrated with additional clinical data in statistical and machine learning models to stratify patients into more homogeneous disease subtypes, contributing to the development of new precision medicine strategies. The study will be initially applied to schizophrenia, inflammatory bowel disease, and coronary artery disease, acting as a guide in the psychiatric, cardiometabolic, and immunological fields.

PI_NAMEs: GARCIA GONZALEZ, JUDIT  (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: biobank;Biological;cardiometabolism;Career Ladders;causal variant;cell type;Cells;Chromosome Mapping;Clinical;Clinical Data;Clinical Pathways;clinical risk;Complex;Computer software;Coronary Arteriosclerosis;Data;Development;Disease;disease heterogeneity;disease model;Disease susceptibility;disorder risk;disorder subtype;Etiology;Exhibits;experimental study;Exposure to;Foundations;functional genomics;Future;Gene Expression;gene network;Genes;Genetic;genetic makeup;Genetic Models;Genetic Risk;genetic variant;genome wide association study;genome-wide;Genomics;Heritability;Heterogeneity;Immunologics;improved;Individual;Inflammatory Bowel Diseases;insight;interest;Intervention;Knowledge;machine learning method;machine learning model;Maps;Medical Genetics;medical schools;Mentors;Mentorship;method development;Methods;Mission;multidisciplinary;National Human Genome Research Institute;Nature;New York City;novel;novel strategies;Outcomes Research;Pathway interactions;patient stratification;Patients;Phase;polygenic risk score;precision medicine;programs;prototype;public database;Research;Research Personnel;Resolution;Risk Factors;RNA analysis;Route;Schizophrenia;skills;Specificity;statistical and machine learning;Statistical Methods;statistics;Subgroup;Symptoms;Techniques;Testing;Tissues;tool;Training;transcriptome sequencing;translational impact;Validation;Work

PROJECT_TITLE: PATHFINDER: Finding the genomic and clinical pathways underlying heterogeneity in complex disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (J2)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: CHICAGO

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

ORG_STATE: IL

PHR: Narrative Regeneration of bone injuries that will not heal on their own remains a significant clinical challenge, as this affects many veterans and soldiers in US Military and there are few viable treatment options. We propose to engineer scaffold-free cell condensation-based vascularized bone tissue using direct assembly of high-density stem cell- laden core-shell microgel and individual cell-only bioinks via new in situ bioprinting technology with precise spatiotemporally controlled delivery of tissue-specific growth factors. This platform strategy to create geometrically complex functional vascularized bone tissue by means of multi-tissue type cellular condensations may represent a powerful clinical therapeutic advance to treat patients suffering from craniofacial bone tissue damage or loss and improve their lives.

PI_NAMEs: ALSBERG, EBEN  (contact)

PROJECT_TERMS: 3-Dimensional;3D Print;active duty;Address;Affect;Air Movements;Architecture;Autologous Transplantation;Bathing;Biocompatible Materials;bioink;bioprinting;bioscaffold;Blood Vessels;bone;Bone Density;bone engineering;Bone Injury;Bone Morphogenetic Proteins;Bone Regeneration;Bone Tissue;Calvaria;cell assembly;Cell Communication;Cell Culture Techniques;Cell Density;Cell Differentiation process;Cells;Cephalic;Clinical;combat;Complex;cost;cost estimate;craniofacial;craniofacial bone;crosslink;Defect;density;design;Development;Devices;disability;Encapsulated;endothelial stem cell;Engineering;experience;Face;Functional Regeneration;Gel;Generations;Geometry;Growth;Growth Factor;Gunshot wound;healing;Health;Health Care Costs;Human;Hydrogels;Immune;Implant;implantation;improved;In Situ;In Vitro;in vivo;Individual;Inflammatory;Injury;innovation;Mechanics;Mental Health;Mesenchymal Stem Cells;Methods;Military Personnel;military veteran;Morbidity - disease rate;musculoskeletal injury;Nature;new technology;novel;osteogenic;Pain;particle;Patients;Pattern;Penetration;Phenotype;Physical condensation;physical property;pre-clinical;Printing;Procedures;Quality of life;Rattus;Reaction;Research Personnel;Resolution;Role;scaffold;self assembly;Shapes;Site;Soldier;spatiotemporal;standard care;stem cells;Structure;System;Techniques;Technology;Therapeutic;three dimensional structure;Tissue constructs;Tissue Engineering;tissue regeneration;Tissues;Vascularization;Vasculogenic;VEGFA gene;Veterans

PROJECT_TITLE: In situ bioprinting of high-density cell-laden core-shell microgel bioinks enabling cellular condensation for vascularized bone tissue regeneration

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This project, titled “Supporting Patients Recovering from COVID” (SPaRC), will build upon the existing multidisciplinary Johns Hopkins Post-Acute COVID-19 Team (JH PACT) out-patient program to expand essential clinical services for, and facilitate patient-centered, equitable care delivery to, people living with long COVID, especially those from under-served communities. SPaRC will build a coalition to strengthen collaboration with, and support for, primary care providers. The SPaRC program will be evaluated using a mixed methods approach, and iteratively refined, within a learning health system, and in collaboration with the SPaRC Stakeholder Advisory Council and the AHRQ Learning Community, to advance Long COVID care.

PI_NAMEs: PARKER, ANN MARIE (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Supporting Patients Recovering from COVID-19 (SPaRC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHS1 HSR-H (01)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE – OVERALL The Mayo Clinic Alzheimer's Disease Research Center (ADRC) will pursue the theme of Multiple Etiology Dementias. The ADRC will intensely focus its efforts on the recruitment on African American/Black, Hispanic/Latino, and rural dwelling communities, and will assess for all ADRC participants' structural and social determinants of health to evaluate the impact of multiple pathologies. Mayo ADRC will share its data, images, and biological specimens widely with the ADRC community and other investigators.

PI_NAMEs: BOEVE, BRADLEY F;PETERSEN, RONALD C (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: African American;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Artificial Intelligence;Basic Science;Biological;Biological Assay;Biological Markers;Black race;blood-based biomarker;Cerebrovascular Disorders;Clinic;Clinical;Clinical Trials;Cognition;cognitive change;cognitive testing;cohort;Collaborations;Communities;community center;Data;data management;data sharing;Dementia;Diagnosis;digital;Disease;education research;electronic data;Etiology;Florida;frontotemporal degeneration;Frontotemporal Lobar Degenerations;Gait;General Population;Genomics;Goals;Grant;Hispanic;Image;imaging modality;Individual;Industrialization;innovation;Institution;Investigation;Knowledge;Language;Latino;Lewy Bodies;Lewy Body Dementia;Lewy Body Disease;Magnetic Resonance Imaging;Methods;mixed dementia;Modality;Modeling;Molecular;multiple omics;National Institute on Aging;Nature;Neurodegenerative Disorders;neuroimaging;neuropathology;next generation;Outcome;Participant;Pathologic Processes;Pathology;Performance;Plasma;Positron-Emission Tomography;Privacy;Process;Protocols documentation;recruit;Research;Research Personnel;Resources;Role;rural dwellers;Rural Population;rural residence;Scanning;Secure;social determinants;social health determinants;Specimen;Speech;structural determinants;structural health determinants;therapy development;Tissues;Training;Underrepresented Populations;Underserved Population;Vascular Cognitive Impairment;Work

PROJECT_TITLE: Mayo Alzheimer's Disease Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Lewy Body Dementia;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: PETERSEN, RONALD C (contact)

PROJECT_TERMS: Advisory Committees;advocacy organizations;African American;Alzheimer's Disease;Alzheimer's disease related dementia;Animals;Area;Award;Biological Markers;Black race;Cerebrovascular Disorders;Clinic;Clinical;Cognitive;cohort;Collaborations;Communication;Complex;Data;data management;data sharing;Dementia;Development;digital;Disease;education research;Educational Activities;Ensure;Faculty;Florida;Foundations;frontotemporal degeneration;Frontotemporal Lobar Degenerations;Funding;Gait;Genetic;Genomics;Goals;Grant;Hispanic;Human Resources;IACUC;Image;Impaired cognition;Individual;innovation;Institution;Institutional Review Boards;International;Language;Latino;Leadership;Lewy Body Dementia;Lewy Body Disease;meetings;Minnesota;mixed dementia;National Institute on Aging;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuropathology;next generation;novel;operation;outreach;Participant;participant safety;Policies;Process;programs;Progress Reports;recruit;repository;Research;Research Activity;Research Personnel;Research Support;Resource Sharing;rural residence;Schedule;screening;Speech;Structure;success;symposium;Techniques;Training;Underrepresented Populations;United States National Institutes of Health;Vascular Cognitive Impairment;Vascular Diseases;virtual;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lewy Body Dementia;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: KNOPMAN, DAVID S (contact)

PROJECT_TERMS: African American;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Autopsy;Behavioral;Biological Assay;Biological Markers;Black race;Blood;burden of illness;cerebrovascular;Cerebrovascular Disorders;cerebrovascular pathology;Clinic;Clinical;clinical conference;clinical practice;Clinical Trials;Cognition Disorders;Cognitive;cohort;Collaborations;Communities;Consensus;data harmonization;Dedications;Dementia;Development;Diagnosis;Diagnostic;diagnostic tool;Diffusion Magnetic Resonance Imaging;digital;digital assessment;digital health;Dimensions;Disease;DNA;Education;Enrollment;Ensure;Ethnic Origin;Etiology;Evaluation;Florida;fluorodeoxyglucose positron emission tomography;Frontotemporal Lobar Degenerations;Funding;Genetic;Genomics;Goals;Grant;Heterogeneity;Hispanic;Image;imaging study;Impaired cognition;Individual;informant;Infrastructure;innovation;interest;Interview;Investigation;Joints;late life;Latino;Leadership;Lewy Body Disease;Liquid substance;Magnetic Resonance Imaging;Measures;Medical Genetics;Medical History;Methodology;mild cognitive impairment;multiple omics;Napping;Nerve Degeneration;neuroimaging;Neurologist;neuropathology;Neuropsychological Tests;next generation;novel diagnostics;outreach;Participant;Pathologic;Pathology;Patient Recruitments;Patients;Persons;Pharmaceutical Preparations;Phenotype;Physicians;Plasma;Populations at Risk;Positioning Attribute;Positron-Emission Tomography;Process;protein TDP-43;Psychometrics;Publications;racial diversity;recruit;Research;research clinical testing;Research Personnel;Research Project Grants;Resources;rural area;rural dwellers;Rural Population;Scanning;Site;social health determinants;Standardization;structural determinants;symposium;tau Proteins;Tauopathies;Technology;Training;Underrepresented Populations;United States National Institutes of Health;White Matter Hyperintensity;Work

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: KREMERS, WALTER K. (contact)

PROJECT_TERMS: African American;Alzheimer's Disease;Alzheimer's disease related dementia;Biological;Biological Markers;Biometry;Black race;central database;Clinical;Clinical Research;Collaborations;Collection;Communities;Complex;Computer software;Data;data access;Data Analyses;data exchange;data management;Data Management Resources;Data Set;data sharing;Database Management Systems;Databases;Dementia;Development;digital;Disease;disease model;education research;electronic data;Electronics;Evaluation;flexibility;follow-up;Foundations;Frontotemporal Lobar Degenerations;Funding;Genomics;Goals;health data;Hispanic;Housing;Impaired cognition;improved;Infrastructure;innovation;instrumentation;Knowledge Portal;Latino;Leadership;Link;Liquid substance;machine learning method;member;Mentors;Methods;Modeling;Neurodegenerative Disorders;neuroimaging;neuropathology;novel;open source;outreach;Participant;Patients;Performance;Preparation;recruit;relational database;repository;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;rural residence;Sampling;Scientific Advances and Accomplishments;Secure;social health determinants;Standardization;Statistical Methods;structural determinants;tool;Underrepresented Populations;Validation;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;vascular contributions;web page

PROJECT_TITLE: Data Management & Statistical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: DICKSON, DENNIS WILLIAM (contact)

PROJECT_TERMS: African American population;age related;age related neurodegeneration;Aging;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amygdaloid structure;Amyloid;Amyloid beta-Protein;Apolipoprotein E;Area;Asian Americans;Autopsy;Biochemical;Biological Assay;biomarker discovery;Black race;Brain;Brain Pathology;brain tissue;Caring;cerebrovascular lesion;cerebrovascular pathology;Clinic;Clinical;clinical conference;Clinical Data;Clinical Medicine;Collection;Consensus;Correlative Study;Data;data communication;data management;Data Reporting;Dementia;Dementia with Lewy Bodies;density;Diagnosis;Diagnostic;digital imaging;digital pathology;Dissection;Documentation;Education;Educational Activities;Electronic Mail;Electronics;Emergency Situation;endophenotype;Enrollment;Ensure;Evaluation;Event;Failure;Family member;Feedback;Florida;Fostering;Freezing;Frontotemporal Lobar Degenerations;Genetic;genetic information;Genotype;Guidelines;Hispanic;Histologic;Image;Image Analysis;Immunohistochemistry;improved;Individual;Institution;Latino;Lewy Body Disease;Maps;Measures;Methods;Mission;molecular imaging;Monitor;National Institute on Alcohol Abuse and Alcoholism;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;Neurologist;neuropathology;Participant;participant enrollment;Pathologic;Pathology;Patients;Phase;Population Heterogeneity;preservation;Probability;Prospective Studies;protein TDP-43;Protocols documentation;Qualifying;Records;Reporting;Research;Research Personnel;Sampling;Schedule;Scheme;Scientist;Senile Plaques;Services;Severities;Shapes;Standardization;System;tau Proteins;Tissue Sample;Tissues;Underrepresented Populations;United States National Institutes of Health;videoconference

PROJECT_TITLE: Neuropathology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: LUCAS, JOHN  (contact)

PROJECT_TERMS: Achievement;Address;African American;African American population;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;Biological Markers;Black race;Brain;career;Caregiver support;Caregivers;Caring;Cities;Clinic;Clinical;clinical care;clinical center;Clinical Trials;cohort;Collaborations;Communities;community based participatory research;community collaboration;community engagement;Community Networks;Community Outreach;community partners;community partnership;community-centered;Dementia;dementia care;Development;Diagnostic;digital;digital tool;Disease;Disparity;Educational Materials;Electronics;empowerment;Enrollment;Ensure;Epidemiology;ethnoracial;ethnoracial minority;Event;experience;Family;Florida;Fostering;Friends;Genomics;Geographic Locations;Goals;health determinants;health disparity;Health Fairs;Health system;Hispanic;Image;Infrastructure;innovation;interdisciplinary collaboration;Knowledge;Latino;Lead;Linguistics;Medical;member;Memory;Mentorship;Methodology;Methods;Minnesota;minority communities;mixed dementia;Modernization;Molecular;neuropathology;new technology;novel;outreach;outreach clinics;Participant;participant retention;Persons;Population;Positioning Attribute;Printing;programs;Public Health;recruit;Research;research data dissemination;Research Personnel;Resources;Risk;Rural;Rural Community;rural dwellers;rural residence;rurality;Science;Scientific Advances and Accomplishments;skills;social;social health determinants;structural determinants;success;Technology;Therapeutic;tool;Training;Trust;Underrepresented Populations;underserved minority;volunteer

PROJECT_TITLE: ORE - Outreach, Recruitment and Engagement Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lewy Body Dementia;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: PETRUCELLI, LEONARD  (contact)

PROJECT_TERMS: Address;African American;alpha synuclein;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-42;assay development;Biological Assay;Biological Markers;Biology;biomarker evaluation;Black race;Cerebrospinal Fluid;Clinic;Clinical;clinical diagnosis;Clinical Trials;Cognition;cohort;Communities;comorbidity;Data;data management;Data Set;Dementia;dementia burden;detection assay;Development;Diagnosis;Diagnostic;Disease;Disparity;Ethnic Origin;Etiology;Exons;Florida;Frontotemporal Lobar Degenerations;functional loss;Genomics;Glial Fibrillary Acidic Protein;Goals;Grant;Health;Heterogeneity;Hispanic;Impaired cognition;improved;Individual;interest;Latino Population;Lead;Lewy Bodies;Lewy Body Disease;Liquid substance;Measures;mixed dementia;neuroimaging;neuropathology;Not Hispanic or Latino;novel marker;outreach;Participant;Pathologic;Pathology;Patients;Performance;Pharmacodynamics;Plasma;Predisposition;Process;prognostic;prognostic performance;protein TDP-43;Proteins;Race;recruit;repository;Research;Research Personnel;Resources;Risk;Sampling;Serum;social health determinants;Specimen;structural determinants;Surrogate Markers;synergism;targeted agent;tau Proteins;tau-1;Transcript;Underrepresented Populations;Validation;Vascular Cognitive Impairment;web site;Work

PROJECT_TITLE: Biomarker Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: MCLEAN, PAMELA J (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease related dementia;Basic Science;Behavioral;Bioinformatics;built environment;career;career development;career life balance;Cerebrovascular Disorders;Clinic;Clinical;clinical application;Clinical Research;Clinical Sciences;Collaborations;Data;Dementia;digital;Disease;Doctor of Philosophy;Education;education research;Educational process of instructing;Educational Status;Educational workshop;Elements;Ethics;Etiology;Evaluation;experience;Faculty;Florida;Fostering;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Genetic;Genomics;Goals;graduate medical education;graduate school;Grant;Individual;Infrastructure;insight;Instruction;interdisciplinary approach;interpersonal conflict;Laboratories;Leadership;lectures;Lewy Body Dementia;Lewy Body Disease;Manuscripts;Massachusetts;member;Mentors;Mentorship;Methods;Minnesota;Minor;mixed dementia;multidisciplinary;Nerve Degeneration;Nervous System Disorder;Neurobiology;Neurodegenerative Disorders;neuroimaging;Neurologist;neuropathology;Neuropsychology;Neurosciences;next generation;Outcome;Participant;Persons;Prevalence;Process;programs;Recommendation;Recording of previous events;Research;Research Design;Research Methodology;Research Personnel;Research Project Summaries;Research Training;Resources;Science;Site;Site Visit;skills;social;Solid;Specimen;Students;Teacher Professional Development;Tissues;Training;Training and Infrastructure;Training Programs;Underrepresented Populations;Vascular Dementia;Wisconsin;Work;Writing

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lewy Body Dementia;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: KANTARCI, KEJAL  (contact)

PROJECT_TERMS: African American;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;Autopsy;Biological;Biological Markers;Black race;Blood Vessels;Brain Pathology;cerebrovascular;Cerebrovascular Disorders;cerebrovascular lesion;cerebrovascular pathology;Classification;Clinic;Clinical;Clinical Trials;cohort;Collaborations;Communities;Complex;Confidentiality of Patient Information;Data;Data Analyses;data management;Dementia;Deposition;design;Development;Diagnosis;Diagnostic;digital;Education;education research;Enrollment;Ethnic Origin;Etiology;Evaluation;Florida;fluorodeoxyglucose positron emission tomography;Frontotemporal Lobar Degenerations;Genetic Risk;Genomics;Goals;high resolution imaging;Hispanic;Image;image processing;imaging biomarker;imaging program;imaging study;Imaging technology;Impaired cognition;individual patient;innovation;innovative technologies;Latino;Lead;Leadership;Lewy Bodies;Lewy Body Dementia;Lewy Body Disease;Liquid substance;Magnetic Resonance Imaging;Measures;mild cognitive impairment;mixed dementia;Multimodal Imaging;multimodal neuroimaging;Nerve Degeneration;neuroimaging;neuroimaging marker;neuropathology;nonalzheimer dementia;novel;older adult;outreach;Participant;participant enrollment;Pathologic Processes;Pathology;Patients;Positron-Emission Tomography;pre-clinical;Procedures;Process;programs;protein TDP-43;Proteins;Protocols documentation;Quality Control;Race;racial diversity;radioligand;recruit;Research;Research Personnel;Research Project Grants;Resources;Role;rural residence;sex as a biological variable;single photon emission computed tomography;Site;social health determinants;Staging;Standardization;structural determinants;Symptoms;tau Proteins;Technology;Training

PROJECT_TITLE: Neuroimaging Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: ERTEKIN-TANER, NILUFER  (contact)

PROJECT_TERMS: African American population;Algorithms;Aliquot;alpha synuclein;Alzheimer's Disease;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;Biochemistry;Biological Markers;Brain;caucasian American;Clinic;Clinical;Code;Cognition;Collaborations;Communities;Data;data management;data repository;data sharing;Dementia;Diagnosis;digital;Disease;disease phenotype;disorder risk;DNA;Education;endophenotype;Ethnic Origin;Etiology;experience;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Funding;Gene Expression;Generations;Genes;Genetic;genetic risk factor;genome wide association study;Genomics;Genotype;Goals;Grant;inclusion criteria;Infrastructure;innovation;Institution;Knowledge;Knowledge Portal;Lead;Leadership;Lewy Bodies;Measures;Methylation;mixed dementia;Molecular;Molecular Profiling;molecular subtypes;Multiomic Data;multiple omics;Mutation;mutation screening;Neurodegenerative Disorders;neuroimaging;neuropathology;new therapeutic target;Not Hispanic or Latino;Office of Administrative Management;Outcome;outreach;Participant;Patients;Phenotype;Plasma;presenilin-1;programs;Quality Control;Race;recruit;repository;Reproducibility;Research;Research Personnel;resilience;Resources;risk variant;RNA;sample collection;Sampling;screening;Seminal;sex;social health determinants;Standardization;statistics;structural determinants;Systems Biology;therapeutic biomarker;United States National Institutes of Health;vascular cognitive impairment and dementia

PROJECT_TITLE: Genomic Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Telehealth

PI_NAMEs: JONES, DAVID T (contact)

PROJECT_TERMS: Achievement;Address;Adoption;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Artificial Intelligence;Attention;Awareness;Caring;Clinic;clinical center;Clinical Research;Clinical Sciences;cognitive testing;Collaborations;Communities;computational platform;Computer software;Data Engineering;data management;Dementia;Development;Diagnosis;digital;Digital biomarker;digital health;digital imaging;digital pathology;digital technology;digital tool;Disease;education research;education resources;Educational workshop;effectiveness evaluation;Engineering;equity, diversity, and inclusion;Ethics;Etiology;Evaluation;Feedback;Fostering;Goals;health disparity;Health Promotion;Health Technology;Healthcare;Image;improved;Infrastructure;innovation;Institution;Knowledge;member;mobile application;Monitor;Motion;multidisciplinary;Neurologic Examination;Neurology;novel;operation;Outcomes Research;outreach;Pathology;Patient Care;Population Heterogeneity;Privacy;Process;programs;Publications;Quality of life;remote monitoring;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;satisfaction;Scientist;sensor;Services;Software Engineering;Source;Specialist;Speech;Stress;Surveys;System;Technology;Telemedicine;Training;Training and Education;Training Programs;Translational Research;wearable device;Work

PROJECT_TITLE: Digital Innovation Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Lung;Pulmonary Fibrosis;Rare Diseases;Scleroderma

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE We propose that degradation of the extracellular matrix protein Fibronectin-EDA (FN-EDA) could be a novel strategy to mitigate the severity of pulmonary fibrosis. I will identify mechanisms of FN-EDA degradation and test the repurposed drug Lonafarnib for its effects on FN-EDA degradation.

PI_NAMEs: EVANKOVICH, JOHN W (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Alternative Splicing;Attenuated;Automobile Driving;Award;Back;Binding;Biological Assay;Bleomycin;burden of illness;Cell surface;cell type;Cells;chimeric antigen receptor T cells;Chronic;Clinical;Collagen;Critical Care;Data;Defect;Degradation Pathway;Deposition;Development;Diagnosis;Disease;drug repurposing;druggable target;effective therapy;Embryo;Embryonic Development;Endosomes;Extracellular Matrix;Extracellular Matrix Degradation;Extracellular Matrix Proteins;Farnesyl Transferase Inhibitor;Fibroblasts;Fibronectins;Fibrosis;fibrotic lung disease;Glycoproteins;Grant;Growth Factor;Half-Life;high throughput screening;Human;Hypersensitivity;idiopathic pulmonary fibrosis;Immune;Immunologic Receptors;In Vitro;in vivo;Inflammatory;insight;Integrins;interstitial;Interstitial Lung Diseases;Investigation;Knockout Mice;Laminin;Learning;Ligands;Lonafarnib;Lung;Lung Diseases;Lysosomes;Medicine;Methodology;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Myofibroblast;National Heart, Lung, and Blood Institute;novel;novel strategies;Oxygen;Pathogenesis;Pathologic;Pathway interactions;patient subsets;Patients;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Physicians;polypeptide;Pre-Clinical Model;prevent;programs;Property;protein degradation;Protein Isoforms;Proteins;Publishing;Pulmonary Fibrosis;receptor;Recycling;Reporting;Research;response;RNA Splicing;Scaffolding Protein;Scientist;Severities;Signal Transduction;Site;Slice;Supportive care;System;Systemic Scleroderma;Testing;Time;Toll-like receptors;trafficking;Training;Transforming Growth Factor beta;Ubiquitin;Ubiquitination;Universities;Variant;Work

PROJECT_TITLE: Fibronectin Extra Domain A Degradation as an Antifibrotic Approach in Lung Fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Z (J2)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE  The response rates of NSCLC patients to immunotherapy remain low despite significant advances in the development of immune checkpoint inhibitors (ICIs). Our proposed research addresses the premise that the MUC1-C oncoprotein suppresses immune surveillance, promotes resistance to ICIs and is a novel target for the development of antibody-drug conjugates in advancing the immunotherapy of NSCLCs.

PI_NAMEs: KUFE, DONALD W. (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Address;Antibodies;Antibody-drug conjugates;C-terminal;Cancer cell line;cancer immunotherapy;Cancer Patient;cancer therapy;checkpoint therapy;citrate carrier;Clinical;cytokine;Development;Epidermal Growth Factor Receptor;Exhibits;experience;extracellular;Extracellular Domain;Genetically Engineered Mouse;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immune mediated destruction;immune resistance;Immunocompetent;Immunologic Surveillance;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;Inflammatory;lung cancer cell;Malignant Neoplasms;Membrane;Modeling;Monoclonal Antibodies;Mucin 1 protein;Mucins;mutant;Mutation;N-terminal;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Oncogenic;Oncoproteins;Pathogenesis;Pathway interactions;Patients;PD-1 blockade;PD-1/PD-L1;PDL1 pathway;Play;Principal Investigator;Production;programmed cell death ligand 1;programs;Reaction;Research;Resistance;response;restraint;Role;Specimen;T-Lymphocyte;targeted agent;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Work;Writing

PROJECT_TITLE: MUC1-C is a target for advancing immunotherapy of non-small cell lung cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-S (J1)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alcoholism, Alcohol Use and Health;Brain Disorders;Cerebrovascular;Childhood Injury;Dementia;Neurodegenerative;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Underage Drinking;Unintentional Childhood Injury

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: NARRATIVE  The neurobiological basis for the co-morbidity between repeat mild traumatic brain injury (rmTBI), intermittent alcohol exposure (IAE) during adolescence, and dementia remains unclear. This proposal will utilize animal models of rm TBI and IAE during adolescence to examine the role of blood-brain barrier (BBB) disruption and how that may drive the development of dementia-associated proteinopathies in adulthood. The results of this work may provide a new therapeutic treatment to treat humans following TBI.

PI_NAMEs: VITA, SYDNEY M (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: 3-Dimensional;Abeta clearance;Adenosine;Adolescence;Adolescent;adolescent alcohol exposure;ADORA2A gene;Adult;Agonist;Alcohol consumption;alcohol effect;alcohol exposure;Alcohols;Amyloid beta-42;Animal Model;Animals;antagonist;Apolipoprotein E;Area;Biological;biomarker identification;Blood - brain barrier anatomy;blood-brain barrier disruption;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain health;career;Cellular Structures;chronic alcohol ingestion;chronic traumatic encephalopathy;Clinical;clinically relevant;comorbidity;cost;cytokine;Data;Dementia;dementia risk;Dependence;Development;disability;Disease;Drops;emerging adult;Event;experience;experimental study;extracellular;Extravasation;Female;Female Adolescents;Future;General Population;high risk;Hippocampus;Homeostasis;Human;Immunohistochemistry;Inflammatory;Injury;insight;Knowledge;Life;Link;male;Male Adolescents;Maps;Measures;mechanical force;Mechanics;Mediating;men;mild traumatic brain injury;Modeling;Molecular Structure;Neurobiology;Neurodegenerative Disorders;novel therapeutics;Outcome;Pathologic;Patient Self-Report;peer;Pericytes;pharmacologic;Production;protein TDP-43;Rattus;Recording of previous events;Research;Role;Rupture;SCH 58261;Series;Sex Differences;Sports;Structure;tau-1;Testing;Tight Junctions;Tissues;Training;Traumatic Brain Injury;underage drinking;Weight;Work

PROJECT_TITLE: Adolescent alcohol exposure exacerbates rmTBI associated BBB disruption and dementia risk

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Hematology;Microbiome;Natural Products;Neurosciences;Nutrition;Orphan Drug;Pain Research;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: BIRMINGHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Sickle cell disease (SCD) affects millions of individuals worldwide and is associated with significant morbidity, mortality, and health care burden. This study investigates the use of a plant-based omega-3-fatty acid (Flaxseed) baked or added to foods to improve inflammation driven pain outcomes in SCD. Flaxseed is an inexpensive, widely available food that has the potential to improve outcomes in SCD and other disease states that are inflammation driven.

PI_NAMEs: DIKE, CHINENYE REBECCA (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Acute;Acute Pain;Adherence;Adult;Adverse effects;Affect;Alabama;American;Anemia;Anti-Inflammatory Agents;Antioxidants;arm;Award;Benchmarking;Bioinformatics;career;Caring;Child;Childhood;chronic pain;Clinical;clinical center;Clinical Sciences;Clinical Trials;Clinical Trials Design;Complement;Complication;Data;Dedications;Dependence;Diet;dietary;dietary approach;Dietary Intervention;Dietary Lignans;dietary manipulation;Disease;Double-Blind Method;Double-blind trial;dysbiosis;Enrollment;enterolactone;Environment;Family;Feasibility Studies;feasibility trial;Fiber;Fish Oils;Flax;Food;Gastroenterologist;Genotype;Goals;gut dysbiosis;gut inflammation;gut microbiome;gut microbiota;healthcare burden;Hemoglobin;Hyperalgesia;Immunology;improved;improved outcome;Individual;Inflammation;inflammatory marker;Ingestion;Institution;Intake;Interleukin-1;Interleukin-6;Intervention;Intervention Studies;Lead;life span;Lignans;Link;marine;Measures;medical schools;medication compliance;Mentored Patient-Oriented Research Career Development Award;Mentorship;metabolomics;Metagenomics;microbial;microbial signature;Microbial Taxonomy;microbiome;microbiota profiles;Monitor;Morbidity - disease rate;mortality;Mucous Membrane;Mus;non-opioid analgesic;novel;novel therapeutics;nutrition;Obesity;Odors;Omega-3 Fatty Acids;Opioid;opioid sparing;Organ;Outcome;Pain;Pain management;Pain Measurement;pain outcome;pain reduction;Participant;Patient Outcomes Assessments;Patients;Pattern;pediatric department;Perception;Physicians;Plant Sources;Plants;Plasma;Population;Property;prospective;Prospective Studies;Psychology;Quality of life;Questionnaires;Randomized;recruit;Regimen;Reporting;Research;Research Infrastructure;Rheumatoid Arthritis;Risk;Scientist;Sickle Cell Anemia;Sickle Cell Trait;side effect;skill acquisition;Source;statistics;success;Supplementation;Taste Perception;Testing;Thalassemia;TNF gene;Training;Translational Research;Universities;willingness;Work

PROJECT_TITLE: A Double Blinded Randomized Feasibility Trial on the Use of Plant Based Omega-3-Fatty Acids  (Flaxseed) to Improve Inflammation Driven Pain Outcomes in Children with Sickle Cell Anemia

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Services;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Patient Safety;Pediatric

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Up to one-third of young infants aged ≤90 days old who present to the emergency department (ED) with viral bronchiolitis have potentially avoidable hospitalizations, contributing to preventable exposure to hospital- acquired infections, undue caregiver distress, and high healthcare costs. An accurate clinical prediction model is needed to identify young infants at low risk of developing respiratory progression who can be safely discharged to home. Using clinical history and physical examination factors, identification of the etiologic viruses, and physiologic time series data measured from bedside monitors, the proposed study will create new prediction models to guide clinical decisions and improve clinical outcomes for young infants with bronchiolitis.

PI_NAMEs: MCLAREN, SON  (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: 2 year old;Accident and Emergency department;acute care;Address;Age;age group;aged;Bronchiolitis;career;Caregivers;Caring;Child;Clinical;clinical development;clinical predictive model;cohort;cost;Critical Care;Data;Data Analyses;Dedications;Distress;Emergency Department evaluation;Emergency department visit;Emergency Medicine;Environment;Epidemiology;Etiology;experience;Exposure to;family burden;Funding;Future;Goals;Health;Health Care Costs;health care service utilization;Health system;Heart Rate;Home;Hospitalization;Hour;improved;Infant;Infant Care;infant outcome;innovation;K-Series Research Career Programs;Knowledge;Learning;Least-Squares Analysis;Literature;Logistic Regressions;Lower Respiratory Tract Infection;Machine Learning;machine learning classifier;Measurement;Measures;Medical Errors;Mentors;Mentorship;model building;Modeling;Monitor;Nosocomial Infections;novel;Outcome;Oxygen;Patients;Pattern;Performance;Physical Examination;Physicians;Physiological;Population;Population Heterogeneity;predictive modeling;productivity loss;Prospective, cohort study;psychosocial;Recording of previous events;Research;Research Methodology;respiratory;Respiratory syncytial virus;Risk;Risk Factors;risk prediction;Sample Size;Scientist;Series;Severities;support vector machine;Techniques;Time;Training;trend;Triage;United States;Universities;Viral;Viral Bronchiolitis;Virus;Work

PROJECT_TITLE: Identification of Young Infants with Bronchiolitis at Low Risk of Developing Respiratory Progression

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Patient Safety;Rare Diseases;Tuberculosis

ORG_CITY: AMHERST

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Human enzymes that are needed to metabolize drugs resemble the structure of the Mycobacterial enzyme (CYP121) that is a current drug target against tuberculosis. Therefore, conventional drug design targeting CYP121 carries a significant risk of unintended inhibition of human drug metabolizing enzymes. The proposed study seeks to take advantage of a unique arrangement of this bacterial enzyme that is necessary for its function and would allow for the development of specific drugs that minimize the risk of drug-related toxicities for patients being treated for this disease.

PI_NAMEs: ESTRADA, DAVID FERNANDO (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Active Sites;Affinity;Antitubercular Agents;Attention;Automobile Driving;Bacteria;Binding;Binding Sites;Biochemical;Biological Assay;Cause of Death;Chimera organism;co-infection;Complement;Complex;Computer Analysis;Coupled;Coupling;covalent bond;COVID-19 pandemic;CYP3A4 gene;Cytochrome P450;Data;design;Development;dimer;Disease;Distal;Drug Design;Drug Interactions;Drug resistance in tuberculosis;Drug Screening;Drug Targeting;Enzyme Inhibitor Drugs;Enzyme Kinetics;enzyme structure;enzyme substrate;Enzymes;Fluorine;Foundations;functional loss;Genes;Goals;Heme;Heme Iron;Hepatic;HIV;Human;Hydrophobicity;In Vitro;Infection;inhibitor;inhibitor therapy;Investigation;isoniazid;Label;loss of function;loss of function mutation;Membrane Proteins;Monitor;monomer;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;mycobacterial;Mycobacterium tuberculosis;Nitrogen;NMR Spectroscopy;novel;Nuclear Magnetic Resonance;pandemic disease;pathogenic bacteria;Patients;Pharmaceutical Preparations;pharmacophore;Phenols;Point Mutation;Prevalence;Reaction;Resistance;Rifampin;Risk;risk minimization;Role;Site;small molecule;Specificity;Structure;Surface;Testing;Therapeutic;Toxic effect;Tuberculosis;tuberculosis treatment;virtual;Work

PROJECT_TITLE: Noncompetitive inhibition of CYP121 dimers from Mycobacterium tuberculosis

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lymphatic Research;Pulmonary Hypertension;Rare Diseases;Tuberous Sclerosis;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Mechanistic target of rapamycin (mTOR) is a highly conserved signaling network upregulated in a number of proliferative lung diseases including pulmonary arterial hypertension (PAH) and lymphangioleiomyomatosis (LAM). This proposal uses three transgenic mouse lines and primary PAH and LAM lung tissues to investigate the role of mTOR hyperactivation on pulmonary vascular remodeling and pulmonary hypertension. The results from this work will help define the role of aberrant mTOR signaling on cellular crosstalk and identify mechanisms of vascular remodeling that can be harnessed to provide potential new therapeutic targets.

PI_NAMEs: LIN, SUSAN M (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: 3-Dimensional;Address;Advisory Committees;behavior in vitro;Bioinformatics;Biological Models;Biology;Blood Vessels;career;career development;cell behavior;Cell Lineage;Cell Physiology;Cells;Cellular biology;Cellular Morphology;ChIP-seq;Coculture Techniques;cohort;Coupled;Data;Defect;defined contribution;Development;Development Plans;Disease;Educational workshop;Endothelial Cells;epigenetic memory;Epigenetic Process;experience;experimental study;Fibroblasts;FRAP1 gene;Functional disorder;Future;Gene Expression;Genomics;Heterogeneity;high resolution imaging;Human;human tissue;Hyperactivity;hypertension treatment;In Vitro;in vivo;innovation;insight;Knockout Mice;Lead;Lung;Lung Diseases;lung imaging;Lung Lymphangioleiomyomatosis;Lung retention;Lymphangioleiomyomatosis;Maintenance;matrigel;meetings;Mendelian disorder;Mentorship;Mesenchymal;Mesenchymal Stem Cells;Mesenchyme;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;new therapeutic target;novel;novel therapeutics;Organoids;Pathway interactions;patient subsets;Patients;PDGFRB gene;Platelet-Derived Growth Factor;Population;prevent;programs;Property;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary Hypertension;pulmonary vascular disorder;pulmonary vascular remodeling;Pulmonary vessels;Regulation;Research;research and development;Research Personnel;response;Role;Serial Passage;Signal Pathway;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;skills;Slice;Structure of parenchyma of lung;Study models;Techniques;Testing;Training;Transcriptional Regulation;Transgenic Mice;Transgenic Organisms;Tuberous Sclerosis;Vascular Endothelial Cell;Vascular remodeling;vasculogenesis;Work

PROJECT_TITLE: Role of mTOR Hyperactivation in Pulmonary Vascular Remodeling

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Mental Health;Neurodegenerative;Neurosciences;Pain Research;Palliative Care;Prevention;Primary Health Care

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Many family caregivers to people with dementia have persistent musculoskeletal pain, which exacerbates their emotional and psychological stress and makes care tasks more difficult to perform. This study aims to adapt an existing evidence-based pain management intervention, Problem Adaptation Therapy for Pain (PATH-Pain), for use by dementia family caregivers who have co-existing persistent pain and high negative emotions. The adapted intervention will be the first evidence-based pain management program customized for dementia family caregivers and will offer a sustainable and scalable approach to person-centered pain management for the growing number of dementia family caregivers who are managing their own physical and mental health comorbidities.

PI_NAMEs: TURNER, SHELBIE G (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Address;adjudication;Affect;Aging;Area;arm;Arthritis;Assessment tool;associated symptom;Behavior;Behavior Therapy;Behavioral;Behavioral Research;care outcomes;care recipients;career;caregiver interventions;Caregivers;caregiving;Caring;Chronic;chronic back pain;Clinical;Clinical Trials;Collaborations;community engagement;comorbid depression;comorbidity;comparison control;Conduct Clinical Trials;Control Groups;Data;Dementia;dementia care;Dementia caregivers;dementia caregiving;design;Development;emotion regulation;Emotional;Emotional Stress;Emotions;Environment;evidence base;Evidence based intervention;experience;Family Caregiver;Family member;Fostering;Foundations;Funding;Future;Geriatrics;Goals;Grant;Health;Health behavior change;High Prevalence;Hypertension;Impairment;improved;informant;innovation;Institutionalization;interest;Intervention;Intervention Studies;Interview;Knowledge;Leadership;Managed Care;medical schools;Mental Depression;Mental Health;Methodology;Methods;Mission;Modeling;mortality;Musculoskeletal Pain;Nature;older adult;Outcome;Output;Pain;Pain management;pain outcome;pain reduction;Pain Research;pain self-management;pain symptom;pain-related disability;Palliative Medicine;Participant;Persistent pain;person centered;Personal Satisfaction;Persons;Phase;physical conditioning;pilot test;poor health outcome;Population;Positioning Attribute;prevent;Primary Care;Problem Solving;programs;Psychological Stress;Randomized, Controlled Trials;Recommendation;Reporting;Research;research and development;Research Personnel;Research Support;Resources;Role;Scientist;Self Care;Self Management;self-management program;skills;stressor;Structure;Surveys;Techniques;Testing;Training;Training Programs;Translational Research;Treatment Efficacy;treatment group;trend;United States;United States National Institutes of Health;Universities;uptake;usability;Work;Writing

PROJECT_TITLE: Adaptation of PATH-Pain for Dementia Family Caregivers Living with Persistent Pain and Negative Emotions

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Rural Health;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: HERSHEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE Rigorous research is needed to identify mechanisms contributing to sexual minority health disparities, particularly from an intersectionality perspective. The intersectionality of geographic location and sexual orientation can profoundly impact prevalence of suicidal thoughts and behaviors, as rural sexual minorities experience disproportionate burden of suicidal thoughts and behaviors, often reside in high-stigma environments, and have limited access to healthcare resources. This project uses an innovative mixed methods approach to clarify acute and dynamic mechanisms underlying suicidal thoughts and behavior disparities among rural sexual minority adults and will inform therapeutic targets for suicide prevention in this uniquely high-risk population.

PI_NAMEs: FORREST, LAUREN NICOLE (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Adult;Age;aged;Award;barrier to care;behavior prediction;Birth;Bisexual;career;Cause of Death;Cellular Phone;Clinical;college;Communities;Data;Data Analyses;Dedications;Disparity;Ecological momentary assessment;Enrollment;Environment;Ethnic Origin;Exclusion;experience;Feeling suicidal;Fibrinogen;follow-up;Future;Gays;Gender;gender minority group;Geographic Locations;Goals;health care availability;Health Services Accessibility;Heterosexuals;high risk population;HIV/AIDS;Hour;Individual;innovation;Institution;Internet;intersectionality;Interview;Learning;Lesbian;Medicine;Mental Health;Mentors;Methods;minority stress;Modeling;Participant;Pattern;Pennsylvania;Persons;Prevalence;prevent;Prevention;Procedures;Process;Protocols documentation;Qualitative Methods;Race;Reporting;Research;Resources;response;Risk;Risk Behaviors;Risk Factors;Rural;Rural Community;rurality;Sampling;Scientist;Severities;sex assigned;Sex Orientation;sexual minority;sexual minority group;sexual minority health;sexual minority health disparity;skills;social stigma;Structure;Subgroup;suicidal behavior;suicidal risk;Suicide;Suicide prevention;Surveys;systematic review;Testing;therapeutic target;Training;Training Activity;Universities;urban area;Work

PROJECT_TITLE: Predicting acute and dynamic suicide risk in rural sexual minorities

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (J1)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative There are significant racial disparities in breastfeeding rates, particularly for non-Hispanic black (NHB) women, who are already disproportionally impacted by adverse health outcomes. The proposed research aims to understand the decision-making process, individual level determinants, and environmental barriers to breastfeeding among NHB women. Findings will inform the systematic and community-engaged design of a tailored breastfeeding peer counselor program to improve breastfeeding outcomes (e.g., initiation, duration, intensity, breastfeeding goals) among NHB women.

PI_NAMEs: KASPRZAK, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Affect;Attention;Award;behavior influence;Behavior Therapy;black women;Breast Feeding;career;career development;Child;Collaborations;Communities;community engaged intervention;community engaged research;Community Health;community intervention;Complex;contextual factors;Decision Making;Dedications;design;Development;Disparity;Dose;Ecological momentary assessment;Education;Equity;Ethnic Population;Evaluation;Exclusive Breastfeeding;Focus Groups;Goals;Health;Health behavior;Health behavior and outcomes;Health Benefit;health disparity;implementation determinants;implementation evaluation;implementation fidelity;implementation research;improved;Individual;Infant;instrument;Intention;Intervention;intervention mapping;Interview;Lactation;Low income;Measurement;Measures;Mentorship;Methods;Minority;Minority Women;Modeling;Mothers;Not Hispanic or Latino;Outcome;peer;Persons;Phase;pilot test;Population Intervention;Postpartum Period;preference;prenatal;prevent;Process;process evaluation;Productivity;Professional counselor;programs;Provider;Qualitative Methods;racial disparity;racial population;randomized controlled design;Research;Research Design;Research Personnel;Services;skills;Social support;socioeconomics;therapy design;Universities;Validation;Vulnerable Populations;White Women;Woman;Work

PROJECT_TITLE: Design and pilot testing of a culturally tailored breastfeeding promotion intervention for non-Hispanic black women


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Cancer;Skin Cancer

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Therapy resistance remains a major problem in effectively treating melanoma despite recent advances in developing chemical inhibitors specifically targeting the most common mutation BRAFV600E in melanoma. This resistance at least in part results from the counteraction of oncogenic phosphatidylinositol 3-kinase catalytic subunit PI3Kβ, a kinase that is highly homologous to, yet functionally divergent from, the other three catalytic subunits PI3Kα/PI3Kδ/PI3Kγ. Based on our recent findings that a nine-residue motif which is found in PI3Kβ, but not in PI3Kα/PI3Kδ/PI3Kγ, we will in this application explore how Selectide-9 comprising this nine-residue motif and a cell- penetrating peptide selectively inactivates PI3Kβ and if Selectide-9 can overcome therapy resistance in melanoma.

PI_NAMEs: SHENG, ZHI  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Affinity;anticancer activity;Binding;Biochemical;BRAF gene;Cancer Patient;Catalytic Domain;Cells;Chemicals;chemotherapy;Clinical;Co-Immunoprecipitations;Complex;cytotoxic;Dissociation;drug development;Drug resistance;Exhibits;Family;fluorescence imaging;Fluorescence Microscopy;Future;genetic signature;Growth;Human;Image;Imaging Techniques;Immune;Immunodeficient Mouse;improved;in silico;In Vitro;in vivo;Individual;inhibitor;innovation;insight;interest;kinase inhibitor;Laboratories;live cell imaging;Lymphoma;MEKs;Melanoma;Melanoma Cell;Melanoma patient;Metabolic;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinase Kinases;Mitogen-Activated Protein Kinases;Monitor;monomer;mutant;Mutation;novel;novel therapeutic intervention;Oncogenic;Outcome;Pathway interactions;patient derived xenograft model;Patients;Penetration;Peptides;Pharmaceutical Preparations;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Phosphotransferases;PIK3CG gene;pre-clinical;Prognosis;Protein Analysis;Protein Kinase;Proteins;Proto-Oncogenes;PTEN gene;Recurrence;Recurrent tumor;Resistance;Resolution;single-cell RNA sequencing;Skin Cancer;success;Testing;Therapeutic;therapy resistant;Toxic effect;tumor;tumor progression;Tumor-Derived;United States Food and Drug Administration;Work

PROJECT_TITLE: Overcoming therapy resistance in melanoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-5 (J1)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Stroke

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Preterm infants with intraventricular hemorrhage are at high risk of developing childhood epilepsy and may provide important insights into epilepsy risk stratification if studied early. This study will capture high-density EEG data from preterm infants with intraventricular hemorrhage during a critical period before epilepsy develops to compare to both early epilepsy and developmental outcomes. The goal of this study is to identify predictive biomarkers directly translatable to future clinical screening and interventions which prevent epilepsy in preterm infants and others at risk.

PI_NAMEs: TRIPLETT, REGINA  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: 2 year old;Address;Age;Area;Award;Biological Markers;Brain;Brain Diseases;Brain Injuries;Brain region;career;Caregivers;Cerebral hemisphere;Child;Childhood;childhood epilepsy;Clinical;cohort;Collection;computational neuroscience;Computing Methodologies;Country;critical period;Data;Data Collection;density;Development;Diagnosis;Disease;Electrodes;Electroencephalography;Electrophysiology (science);Epilepsy;experience;extreme prematurity;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;Goals;high risk;high risk population;Hippocampus;improved;indexing;infancy;Infant;Infantile spasms;Injury;innovation;insight;Institution;Intervention;intraventricular hemorrhage;Learning;Life;Link;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Measures;Medical Records;Mentored Patient-Oriented Research Career Development Award;Mentors;Modeling;Motor;Motor Cortex;multidisciplinary;multimodality;Neonatal;Neonatal Intensive Care Units;Neonatology;neurodevelopment;Neurodevelopmental Impairment;neuroimaging;Neurologic;Outcome;outcome prediction;Parents;Partial Epilepsies;Pathologic;Patients;Phase;Physicians;Play;Populations at Risk;predictive marker;Predisposition;Pregnancy;Premature Infant;prevent;Prevention;prospective;Prospective Studies;Qualifying;Questionnaires;Research Personnel;Resistance;Risk;Risk Assessment;Risk Marker;risk stratification;Role;Sampling;Scientist;screening;Seizures;Signal Transduction;skills;source localization;Specificity;targeted treatment;Techniques;Testing;Time;Toddler;Training;treatment effect;Ventricular;Visual

PROJECT_TITLE: Epilepsy and Neurodevelopmental Risk Stratification in Very Preterm Infants with Intraventricular Hemorrhage

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Biomedical Imaging;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: CAMBRIDGE

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

PHR: Project Narrative Studies focusing on regeneration within the nervous system hold great potential for the development of therapeutic approaches that aim to generate cures for central nervous system injury and degeneration. In this project, I aim to establish the emerging model Danionella cerebrum – one of the world's smallest vertebrates and a member of a clade of vertebrates (teleost fish) that can regenerate after brain injury – as a novel vertebrate model system for nervous system function, and regeneration research. Combining single-cell RNA sequencing, cell-type-specific ablations, and live calcium imaging will allow study of regeneration in the central and peripheral nervous system, and reveal principles concerning the functional and structural basis of regeneration in specific neural circuits.

PI_NAMEs: ATABAY, KUTAY DENIZ  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Ablation;Acceleration;Acute;Adult;Affect;Animals;Area;Atlases;Behavioral;Biological Models;Brain;Brain imaging;Brain Injuries;Brain region;Calcium;Cell division;cell type;Cells;Central Nervous System;central nervous system injury;Cerebrum;Chronic;Communities;Compensation;Complex;Computing Methodologies;Data;Data Set;Development;Disease;Evolution;experimental study;Fishes;Fostering;Functional Imaging;Functional Regeneration;Future;Generations;Genes;Genetic;genetic approach;Heart;Human;Image;imaging approach;imaging platform;imaging study;Injury;injury recovery;insight;Label;Lasers;Learning;member;Memory;Mentors;Microscopy;Microsurgery;Modeling;Molecular;Natural regeneration;Nerve Regeneration;Nervous System;Nervous System Physiology;Nervous System Trauma;neural;neural circuit;neurodevelopment;neurogenesis;neuron regeneration;neuronal circuitry;neuronal patterning;Neurons;Neurosciences;Nitroreductases;novel;Optics;optogenetics;Organism;Pattern;Peripheral Nervous System;Phase;progenitor;programs;regeneration potential;Regenerative capacity;Regenerative research;Research;Resources;response;RNA Probes;Role;single-cell RNA sequencing;Site;Stimulus;success;Surgical Injuries;System;Techniques;teleost fish;therapeutic development;Therapeutic Intervention;Tissue Model;Tissues;tool;Training;transcriptome;Validation;Vertebrate Biology;Vertebrates;Work

PROJECT_TITLE: The world’s smallest vertebrate brain: A new model for nervous system function and regeneration research

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY

PHR: Project Narrative Researchers gather a wide range of complex genetic information in order to comprehend the intricate factors involved in the development and treatment of cancer. This proposal develops, expands, and sustains essential software and data resources that aid cancer researchers in effectively managing and analyzing this information using advanced computational and statistical approaches.

PI_NAMEs: DAVIS, SEAN ;WALDRON, LEVI  (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Adopted;Advanced Malignant Neoplasm;anti-cancer research;Architecture;Bioconductor;Biological Assay;Cancer Biology;cancer genomics;cancer therapy;cBioPortal;Cells;chatbot;cloud based;Collaborations;Communities;Complex;Computer software;Data;Data Analyses;data format;data infrastructure;data integration;data management;Data Provenance;data repository;data resource;Data Set;data sharing;Development;Development Plans;Distributed Systems;DNA Sequence;Documentation;Ecosystem;Educational workshop;empowerment;Ensure;Epigenetic Process;experience;experimental study;extracellular vesicles;FAIR principles;feature extraction;flexibility;Fostering;Friends;Funding;Gene Expression;genetic information;genomic data;Goals;high standard;Histopathology;Image;Image Analysis;improved;indexing;Infrastructure;interoperability;Knowledge;Language;large language model;learning materials;Maintenance;Malignant Neoplasms;Memory;Metadata;Methods;Modernization;Molecular;Molecular Biology;multimodal data;multimodality;next generation;novel;open source;operation;outreach;parallelization;Process;programs;Proteins;Recording of previous events;Records;repository;Research;Research Personnel;Resources;single-cell RNA sequencing;skills;software infrastructure;Statistical Data Interpretation;statistics;Structure;success;System;The Cancer Genome Atlas;The Cancer Imaging Archive;tool;Training;training opportunity;Training Support;transcriptome sequencing;transcriptomics;Update;usability;Validation;Vertebral column

PROJECT_TITLE: Cancer Genomics: Integrative and Scalable Solutions in R/Bioconductor

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-5 (J2)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Precision Medicine;Prevention;Primary Health Care;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The overdose crisis is a pressing issue, and there is a need to implement evidence-based interventions for opioid use disorder (OUD) in Federally Qualified Health Centers (FQHCs). To address this need, I propose developing, adapting, and testing the ReTAIN program intervention package to implement measurement- based OUD care using patient-reported outcome measures (PROMs) to monitor treatment progress and improve patient retention in FQHCs. As part of a mentored research training program, this award will enable me to gain expertise in implementation science and become a leading independent researcher with dual expertise in implementation science and addiction medicine. My goal is to bridge the evidence-to-practice gap by studying optimal approaches for integrating evidence-based addiction medicine interventions in FQHCs and other primary care settings.

PI_NAMEs: PYTELL, JARRATT  (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: addiction;Address;Administrator;Adult;Area;Assessment tool;Award;Buprenorphine;buprenorphine treatment;candidate identification;candidate validation;career;Caring;Characteristics;clinical care;Collection;contextual factors;cost;Data;Decision Making;design;Development;Effectiveness;effectiveness evaluation;Epidemic;Evaluation;evidence base;Evidence based intervention;Evidence based practice;Evidence based treatment;experience;Federally Qualified Health Center;Fellowship;Focus Groups;Funding;Future;Goals;Guidelines;Helping to End Addiction Long-term;Hybrids;implementation evaluation;implementation intervention;implementation outcomes;implementation research;implementation science;implementation/effectiveness;improved;Individual;individualized medicine;Internal Medicine;International;Intervention;intervention program;Knowledge;Learning;Length;Maintenance;Measurement;medical specialties;Medically Underserved Area;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;minority communities;minority patient;Monitor;National Institute of Drug Abuse;opioid overdose;opioid use disorder;Outcome;Outcome Measure;Overdose;overdose prevention;Participant;Patient Care;patient oriented;Patient Outcomes Assessments;patient response;patient retention;Patient-Focused Outcomes;Patients;pilot test;Practical Robust Implementation and Sustainability Model;pragmatic trial;Prevention strategy;Primary Care;primary care setting;primary outcome;programs;prototype;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Personnel;Research Training;Resources;Sampling;satisfaction;Scientist;secondary outcome;Site;skills;Specialist;Strategic Planning;substance use;Surface;systematic review;Tea;Testing;Therapeutic;Training;Training Programs;treatment as usual;treatment guidelines;treatment response;underserved community;usability;user centered design;women patients;Work

PROJECT_TITLE: Patient Reported Outcome Measures to Individualize Treatment And Improve ReteNtion (ReTAIN) program in primary care-based OUD treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (02)]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Hematology;Lung;Precision Medicine

PHR: PROJECT NARRATIVE Peripheral blood eosinophil count, a good molecular biomarker in asthma, has been inconsistent in chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality in the United States, leading to mixed results for targeted therapies. Since COPD is a heterogenous and complex disease, it is necessary to investigate the relationship of eosinophils with activated platelets, which perpetuate inflammation and regulate immune cell function. Understanding the complex interplay of platelet-eosinophil conjugates with COPD clinical outcomes and of platelet activation with eosinophil activity furthers the knowledge of inflammatory and immune mechanisms in COPD and provides a foundation for future clinical trials investigating precision therapies.

PI_NAMEs: FAWZY, ASHRAF  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: activation product;Acute;Adrenal Cortex Hormones;Agonist;Algorithms;Aspirin;Asthma;Biological;Biological Markers;Blood Platelets;Blood specimen;Cardiovascular Diseases;Cardiovascular system;CCL26 gene;Cell Physiology;Cells;Chronic Obstructive Pulmonary Disease;Circulation;Clinical;Clinical Trials;comorbidity;Complex;Data;Disease;Endothelium;Enrollment;eosinophil;Excretory function;Exercise Tolerance;experimental study;Flow Cytometry;former smoker;Foundations;Future;Glycoproteins;Goals;Health Status;Immune;improved;In Vitro;in vivo;Incidence;Individual;Inflammation;Inflammatory;Infrastructure;Inhalation;Integrins;Interleukin-13;Interleukin-4;Interleukin-5;Intervention Studies;Investigation;ITGB2 gene;Knowledge;Laboratories;Leukocytes;Lung;Lung Diseases;Measurement;Measures;Molecular;molecular marker;molecular phenotype;Monoclonal Antibody Therapy;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Nitric Oxide;novel therapeutics;Observational Study;Outcome;P-Selectin;Parents;Participant;Pathway interactions;Patients;peripheral blood;personalized medicine;Phenotype;Plasma;Platelet Activation;Platelet Inhibitors;precision medicine;Precision therapeutics;Proteins;Protocols documentation;Quality of life;Questionnaires;recruit;respiratory;respiratory morbidity;Respiratory Signs and Symptoms;response;Role;sample collection;Sampling;Severity of illness;Spirometry;Structure;Structure of parenchyma of lung;Surface;Symptoms;systemic inflammatory response;targeted treatment;Thromboxane A2;Thromboxane B2;Time;TNFSF5 gene;trafficking;treatment response;United States;urinary;Whole Blood;Work

PROJECT_TITLE: Role of platelet-eosinophil interactions in COPD morbidity


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE Episodic memory is central to the human sense of self and wellbeing, and its disruption in Alzheimer’s disease or other forms of dementia profoundly reduces quality of life. This work contributes to an understanding of the fundamental mechanisms, shared across vertebrate species, by which the hippocampus supports episodic memory function. Results will have broad scientific relevance for the development of future technology to improve memory function in health, and alleviate functional declines with age and disease.

PI_NAMEs: CHETTIH, SELMAAN  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: 3-Dimensional;Address;Affect;age related decline;Alzheimer's Disease;Anatomy;Area;Bar Codes;Behavior;Behavioral;Behavioral Paradigm;Biological Models;Birds;Brain;career;career development;Cells;Code;Cognitive;Collection;Computer Models;Data;Decision Making;Dementia;design;Development;Development Plans;Disease;Electrophysiology (science);Elements;Environment;Episodic memory;Event;Exhibits;experience;experimental study;Faculty;Family;flexibility;Food;Foundations;functional decline;Future;Goals;Health;Hippocampus;Human;improved;Individual;Lateral;Link;Location;Locomotion;Mammals;Maps;Mediating;Memory;memory recall;memory retrieval;Mentors;model development;model organism;Modeling;Motor;motor behavior;motor control;neural;neural circuit;Neurons;Neurosciences;novel;Nucleus Accumbens;Organism;Output;Pattern;Personal Satisfaction;Phase;Physiological;Population;Positioning Attribute;Postdoctoral Fellow;Preparation;preservation;Probability;Process;Quality of life;Research;Research Support;response;Retrieval;Role;Saccades;Series;Signal Transduction;spatial memory;Structure;System;Techniques;Technology;technology development;tenure track;Time;Training;Universities;Vertebrates;Visual;way finding;Work

PROJECT_TITLE: Hippocampal Mechanisms of Episodic Memory Recall and their Contribution to Naturalistic Navigation Decisions

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Kidney Disease;Prevention;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE The increasing salinity of groundwater is a key emerging global environmental health risk factor for hundreds of millions of adults, including in the United States. With climate change increasing these risks, there is a vital need to understand the consequences of differential levels of drinking water salinity on risk of dehydration, water insecurity, kidney damage, and hypertension—all significant public health concerns, particularly in hot environments. The findings from the proposed study will inform policy recommendations about maximum salinity levels for health and interventions to prevent exposure to drinking water salinity and its related public health consequences.

PI_NAMEs: ROSINGER, ASHER Y. (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Adult;Affect;African;age difference;aged;Albumins;anthropogenesis;Area;Attention;Awareness;Biological Markers;Blood Pressure;blood pressure control;blood pressure elevation;Body Water;Chronic;Chronic Kidney Failure;climate change;Communities;Coupled;Creatinine;Dehydration;Diastolic blood pressure;Diet;dietary salt;Dose;drinking water;Dryness;Enrollment;Environment;Environmental Exposure;Environmental Health;evidence base;Excretory function;Exposure to;extreme heat;food insecurity;Fresh Water;global environment;ground water;Guidelines;Health;health disparity populations;health inequalities;Health protection;Heat Stress;Heavy Metals;Homeostasis;Human;Human Biology;Hydration status;hydrology;Hypertension;Individual;Injury;Injury to Kidney;innovation;Intervention;Kenya;Kidney;kidney dysfunction;Laboratories;Lactation;LCN2 gene;Lead;Life Cycle Stages;Link;longitudinal design;Longitudinal Studies;low income country;marginalization;marginalized population;Measurement;Measures;Mediating;Mediation;men;Metals;Methods;Microalbuminuria;multimodality;Natural experiment;novel;Outcome;Participant;people of color;Physiological;point of care;Policies;policy recommendation;Population;pregnant;Prevalence;prevent;prospective test;Proteins;Proteinuria;Public Health;Recommendation;renal damage;Renal function;reproductive;Research;Resource-limited setting;response;Risk;Risk Factors;Safety;Saline;salt intake;Salts;screening;Seasonal Variations;Seasons;Serum;sex;Site;social;sociodemographics;Sodium;Sodium Chloride;Source;Stream;stressor;System;Temperature;Testing;Thirst;Time;United States;Urine;Variant;Water;water quality;Woman;Work

PROJECT_TITLE: Drinking water salinity in a hot-dry environment: Hydration, kidney function, and blood pressure

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Pathological social aggressive behavior affects 45% of individuals with Alzheimer’s disease, and is associated with poorer quality of life, enhanced burden on caregivers, and poorer outcomes overall. The pathophysiological basis of these symptoms is unknown. By systematically mapping the ability of oxytocin-sensitive neuromodulatory circuits connecting the hippocampus to the lateral septum to control social aggressive behavior and the impact of AD-related pathology on this circuit, we explore the possibility that these devastating neuropsychiatric symptoms can be treated early in disease progression.

PI_NAMEs: LIU, JINGJING  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Acute;Affect;Aggressive behavior;Agitation;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;American;Amyloid beta-Protein;amyloid pathology;Animal Behavior;Animals;antisocial behavior;Anxiety;anxiety states;Behavior;Behavior Control;behavioral outcome;Biophysics;Brain region;career;Caregiver Burden;Caregivers;Cell Nucleus;Clinical;Cognition;Cognitive;Complex;computational neuroscience;Coupled;Data;design;Development;Disease;Disease Progression;Disinhibition;Distress;early onset;Economic Burden;Exhibits;Familiarity;Goals;Grant;Health;Heterogeneity;Hippocampus;Hospitalization;Human;human old age (65+);Hypothalamic structure;Impaired cognition;Impairment;improved;in vivo;Individual;Infusion Pumps;innovation;Institutionalization;Interruption;Ion Channel;knock-down;Lateral;Lesion;Literature;Maps;Mediating;Membrane;Memory;Mentors;Modernization;Molecular;Motivation;mouse model;mRNA Expression;Mus;neural;neural circuit;Neurobiology;neuromechanism;Neurons;Neuropeptides;neurophysiology;neuropsychiatric symptom;neuropsychiatry;neuroregulation;non rapid eye movement;novel;Optics;optogenetics;Outcome;Oxytocin;Oxytocin Receptor;patch sequencing;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Peptides;Perception;Pharmacology;Physiology;Positioning Attribute;programs;Quality of life;Reagent;receptor expression;recruit;Regulation;Research;research and development;Research Personnel;response;Role;Senile Plaques;Signal Transduction;Sleep;Slice;social;social anxiety;social attachment;Social Controls;social deficits;Social Functioning;Social Hierarchy;social implication;Social Interaction;socioeconomics;spatiotemporal;Stimulus;Symptoms;Synapses;System;Techniques;Testing;therapeutic development;therapeutic target;tool;Training;translational potential;transmission process;tumor;Withdrawal;Work

PROJECT_TITLE: Decoding the Mechanisms of Oxytocinergic Regulation in the Hippocamposeptal Circuit: Implications for Social Dysfunction in Alzheimer's Disease

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Nonsense Mediated mRNA Decay (NMD) degrades both aberrant transcripts and “normal” transcripts with other specific features, impacting around 10% of the transcriptome. This project will investigate the biological roles and molecular functions of UPF3, a disease-linked core NMD factor, in both human cells and zebrafish development. Taken together, this study will help us understand how UPF3-activated NMD and transcriptional regulation is modulated, and elucidate connections between mRNA decay and transcriptional regulation.

PI_NAMEs: ARVOLA, RENE MARLENE (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Biological;Biological Assay;Biological Models;Cell Nucleus;Cells;Compensation;Complex;Cytoplasm;Data;Deposition;Development;Disease;Eukaryota;Event;Exons;Feedback;Genes;Genetic;Genetic Transcription;genomic locus;histone methyltransferase;Histones;Human;Immunoprecipitation;in vivo;Link;Mammals;Mass Spectrum Analysis;Mediating;member;Mentors;messenger ribonucleoprotein;Messenger RNA;Modeling;Molecular;mRNA Decay;Nuclear;Nuclear Import;nucleocytoplasmic transport;Outcome;overexpression;paralogous gene;Phase;premature;Process;Proteins;Proteomics;Regulation;Reporter;Research Training;response;Rest;RNA Binding;RNA Decay;Role;Terminator Codon;Testing;Tissues;Transcript;Transcriptional Regulation;transcriptome;Work;Zebrafish;zebrafish development

PROJECT_TITLE: Investigating UPF3 paralog function in Nonsense-Mediated mRNA Decay and Genetic Compensation

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-8 (MK)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: Chicago

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Alzheimer's disease (AD) is a neurodegenerative disease characterized by a failure in synapses and consequently the progressive deterioration of cognitive functions. The amyloid β peptide (Aβ) and APOE genotype are critical initiators that trigger the progression of Alzheimer’s Disease (AD) I propose an optical imaging approach to investigate the loss of synaptic function associated with Aβ and APOE genotype contribute to the physiological consequences of aging and AD.

PI_NAMEs: POTCOAVA, MARIANA CAMELIA (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: absorption;Action Potentials;Affect;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Animal Model;apolipoprotein E-3;apolipoprotein E-4;Apoptosis;Applied Skills;Area;Behavioral;Brain;Brain region;Buffers;Calcium;Cognition;cognitive function;Complex;Custom;Data;Defect;Dementia;design;Detection;Deterioration;Diagnosis;Disease;disease model;effective therapy;Elements;Endothelium;Equilibrium;Event;Excision;Excitatory Synapse;Exocytosis;Failure;Fluorescent Dyes;Foundations;Functional disorder;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Genetic;Genetic Engineering;genetic risk factor;Genotype;Glutamates;Goals;Hippocampus;Holography;Homeostasis;Image;imaging approach;Impaired cognition;Inflammatory Response;instrument;Invaded;irradiation;Laboratories;LDL-Receptor Related Protein 1;lectures;Light;Maps;Measures;Mediating;Memory;Memory Loss;Mentors;Metabolism;Microglia;Microscope;Mitochondria;Modeling;Modernization;mouse model;Mus;Nerve Degeneration;neural;Neurites;Neurodegenerative Disorders;neuron loss;neuronal circuitry;Neurons;neurotransmission;neurotransmitter release;novel strategies;optical imaging;optical lattices;Optics;Pathogenesis;Pathologic;Phase;Phenotype;photonics;Phototoxicity;Physics;Physiological;postsynaptic;presynaptic;Presynaptic Terminals;Probability;Process;programs;Proteins;Pump;Research;Resolution;Resources;response;Role;Sampling;Scanning;sensor;sex;Signal Transduction;Signaling Molecule;skills;Slice;SNAP receptor;spatiotemporal;Specialist;Stimulus;Synapses;synaptic function;Synaptic Transmission;Synaptic Vesicles;Time;Tissues;Training;Training Programs;Visualization;voltage

PROJECT_TITLE: Imaging Synaptic Decline in Models of Alzheimer's Disease

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Chronic Pain;Clinical Research;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Pain Research;Patient Safety;Peripheral Neuropathy;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Trigeminal Neuralgia (TN) is a debilitating orofacial condition associated with severe pain, and undertreatment can lead to a decline in quality of life for older adults. The study aims to investigate the optimal pharmacological treatment approaches for TN among aging Americans by documenting patient-reported experiences of diagnosis and treatment, developing a validated algorithm to identify incident TN cases in Medicare data, and investigating the risk of injurious falls caused by different treatment options using advanced causal inference methods and machine learning techniques. This research is critical for improving clinical outcomes and quality of life for older adults living with TN, while also contributing to the development of precision pain care and comparative effectiveness research in this population.

PI_NAMEs: HINCAPIE CASTILLO, JUAN MANUEL (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: active comparator;advanced analytics;Adverse drug event;adverse drug reaction;Affect;Age;Aging;aging population;Algorithms;American;analytical method;anti-epileptic agents;Area;Biomedical Research;Carbamazepine;Caring;Case Study;Central Nervous System;Clinical;Cohort Studies;Collection;comorbidity;comparative;comparative effectiveness;Comparative Effectiveness Research;comparative safety;Competence;Data;Data Analytics;Data Collection;Data Linkages;Data Sources;debilitating pain;design;Development;Diagnosis;Diagnostic;eHealth;Electronic Health Record;Epidemiology;Evaluation;experience;fall injury;falls;forest;Foundations;frontier;Future;gabapentin;Goals;Guidelines;Health;Healthcare;Heterogeneity;high risk;Hospitals;improved;Incidence;individual patient;Interview;K-Series Research Career Programs;Knowledge;Learning;Literature;Lived experience;Machine Learning;machine learning algorithm;machine learning method;Manuals;Measures;Medical;Medicare;Medicare claim;medication safety;Mental Depression;Mentored Research Scientist Development Award;Mentors;Methods;National Institute of Dental and Craniofacial Research;Newly Diagnosed;North Carolina;novel;older adult;older patient;orofacial;Orofacial Pain;Outcome;oxcarbazepine;Pain;Pain management;painful neuropathy;patient engagement;patient population;Patient-Centered Care;Patients;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacologic;Pharmacological Treatment;Population;Quality of life;Recommendation;Recording of previous events;Reporting;Research;Research Personnel;Risk;Risk Estimate;Safety;safety study;skills;Support Groups;Surveys;Techniques;Testing;Training;treatment effect;treatment risk;Trigeminal Neuralgia;Universities;Variant;Woman

PROJECT_TITLE: Real-world Evidence Study with Patient Input to evaluate Treatment Effects in Trigeminal Neuralgia (RESPITE-TN)

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVES: This research introduces a unique multi-trait model that leverages extensive electronic health records to bolster disease prediction and mapping. Addressing the constraints of current genomic studies enhances personalized medicine through optimized treatment strategies and deeper insights into the genetic relationships among complex human diseases. Furthermore, it promotes health improvement and disease prevention, reinforced by rigorous model validation using extensive data sets and expert analyses.

PI_NAMEs: LEE, HYUNKYU  (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Accounting;Address;Affect;All of Us Research Program;Anxiety Disorders;biobank;Biological;Biological Markers;career;case control;Chronic Kidney Failure;cohort;Complex;Data;Data Analyses;data privacy;Data Set;data sharing;design;Disease;Disease susceptibility;disorder prevention;disorder risk;Drug Targeting;Effectiveness;electronic health data;Electronic Health Record;Electronic Medical Records and Genomics Network;Ensure;experience;Family;Foundations;Funding;Genetic;genetic approach;Genome;genome wide association study;genomic data;Genomics;Genotype;Goals;Health;Health Promotion;Heterogeneity;human disease;improved;Individual;insight;interest;Joints;Kidney Diseases;Knowledge;large scale data;Length;Link;Logistic Regressions;Maps;Mentors;Methods;Modeling;neglect;neuropsychiatric disorder;non-genetic;Normal Statistical Distribution;novel;Odds Ratio;Outcome;Partner in relationship;Pattern;Performance;personalized medicine;Phenotype;phenotypic data;pleiotropism;Population;Postdoctoral Fellow;predictive modeling;Probability;Process;programs;Recording of previous events;Research;Risk;Risk Assessment;Risk Estimate;risk prediction;Sampling;Sampling Biases;Selection Bias;Statistical Methods;Sum;Target Populations;Training;trait;treatment optimization;treatment strategy;Validation;Work

PROJECT_TITLE: Multi-Trait Analysis in Large-Scale Biobank Datasets Linked to Electronic Health Records.

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (J2)]