NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Infectious Diseases;Lung;Regenerative Medicine

PI_NAMEs: GRANDE-ALLEN, KATHRYN JANE (contact)

PROJECT_TERMS: 3-Dimensional;3D Print;Acceleration;airway epithelium;Anatomy;Biocompatible Materials;Biological Models;Biomechanics;Biomedical Engineering;Biomimetics;Biophysics;Calibration;Cardiovascular system;Categories;Cell Adhesion;cell community;Cell Culture Techniques;cell transformation;Cells;Coculture Techniques;Communicable Diseases;Computer Models;Connective Tissue;cost;design;Development;Disease;Encapsulated;Engineering;Enteral;enteric infection;Environment;Epithelial Cells;Epithelium;experience;Extracellular Matrix;Functional disorder;Funding;gastrointestinal;gastrointestinal epithelium;gastrointestinal system;Goals;Human;human disease;Human Resources;human tissue;Hydrogels;Immune;improved;in vitro Model;Individual;Infection;Infectious Diseases Research;intestinal epithelium;Intestines;Knowledge;Leadership;Liquid substance;Lung;Lung infections;mechanical behavior;mechanical load;Mechanical Stimulation;member;Modeling;Modification;Molds;Mucous body substance;Mucous Membrane;Neurons;novel;Oxygen;oxygen transport;pandemic disease;particle;pathogen;Pathogenesis;Perfusion;Physical environment;Physiological;Physiology;Pre-Clinical Model;Production;professor;Property;Public Health;Research;Research Personnel;respiratory;Respiratory Disease;Respiratory Tract Infections;Rice;Role;screening;Services;Surface;System;Technology;Technology Transfer;Testing;Time;Tissue Engineering;Tissues;tool;Training;transmission process;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Engineering MicroEnvironment Core (EMEC)


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Alzheimer's disease is highly heritable, yet the genetic factors that contribute to its pathogenesis remain unclear; thus, identifying such risk factors is critical for understanding the disease pathology and developing potential therapeutics. While severe mutations in CAPICUA (CIC) cause intellectual disability, a less severe mutation is associated with Alzheimer's disease. This study aims to evaluate if the less severe mutation in CIC can potentiate Alzheimer's pathology, providing a framework for how partial impairment of a gene that causes intellectual disability can serve as a risk factor for Alzheimer's disease.

PI_NAMEs: LEE, HAMIN  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Ablation;Acceleration;Affect;Age of Onset;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid precursor protein processing;ataxin-1;Behavioral Assay;behavioral phenotyping;beta secretase;beta-site APP cleaving enzyme 1;Binding;Body Weight;Brain;Cells;Child;Co-Immunoprecipitations;Cognition;cohort;Complex;conditional knockout;CRISPR/Cas technology;derepression;Development;Disease;Enzymes;ETV4 gene;exome;experimental study;Gene Expression;Genes;Genetic;genetic corepressor;Genetic Transcription;genome wide association study;Goals;Heritability;Heterozygote;Hippocampus;HMG-Box Domains;Human;Impairment;in silico;in vivo;insight;Intellectual functioning disability;Knock-in Mouse;Knock-out;Knockout Mice;Late Onset Alzheimer Disease;Learning;Link;loss of function;loss of function mutation;Loss of Heterozygosity;Measures;Mediating;Memory impairment;mouse model;Mus;Mutation;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;novel therapeutics;overexpression;paralogous gene;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Perinatal mortality demographics;Persons;Phenotype;Physiological;Proteins;Proteolysis;Repression;Risk Factors;risk variant;Role;secretase;Senile Plaques;Severities;Syndrome;System;Testing;Therapeutic;therapeutic target;Transcription Repressor;Up-Regulation;Variant;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: Evaluating the functional consequences of Alzheimer's disease-associated variant CICP36L


ADMINISTERING_IC: MD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative  Patients and families with limited English proficiency experience substantial barriers to communication in the healthcare setting, leading to medical care that is less safe, less efficient, less effective, and inequitable. Professional interpreter use has repeatedly been shown to improve outcomes and reduce disparities, yet it remains widely underused. This study will test two discrete, scalable implementation strategies for improving professional interpreter use in primary care, while collecting detailed information about mechanisms of action and costs that will be applicable to many sites of care and contribute meaningfully to the goal of reducing communication-based disparities. .

PI_NAMEs: LION, KATHERINE CASEY (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Address;Adherence;Adopted;Adult;Affect;Articulation;behavior change;Caring;Childhood;Clinic;Clinic Visits;Communication;compare effectiveness;Comprehension;cost;cost effective;Diagnosis;Disparity;Disparity population;disparity reduction;Education;Effectiveness;effectiveness/implementation study;Enrollment;Equity;Event;Evidence based practice;experience;Face;Family;Goals;handheld mobile device;health care disparity;health care quality;health care service organization;health care settings;implementation strategy;improved;improved outcome;incremental cost-effectiveness;Inequity;Infrastructure;insight;Interview;Knowledge;Language;Learning Module;Legal;Limited English Proficiency;Link;Medical;Methods;Modeling;multi-component intervention;novel;Online Systems;Outcome;outcome disparities;Parents;Pathway interactions;patient subsets;Patients;Persons;Population;pressure;Primary Care;primary care clinic;primary care setting;primary outcome;Production;Provider;provider behavior;Randomized;Research Personnel;Risk;Safety;satisfaction;Sequential Multiple Assignment Randomized Trial;Site;skills;Spanish;Surveys;System;Technology;Telephone;Testing;Theoretical Domains framework;Time;trial design;Uncertainty;United States;Video Recording;Visit;wireless

PROJECT_TITLE: Mobile Video interpretation to Optimize Communication Across Language barriers: mVOCAL

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Most precision medicine initiatives have not yet reached the clinic and are still yet to deliver effective individualized treatments for common diseases. The outcomes of this project will allow us to better characterize heterogeneity in complex disorders by identifying cell type-speciﬁc transcriptional mechanisms underlying disease phenotypes, and developing accurate and robust disease-risk stratiﬁcation methods. These risk prediction methods will be portable to different population ancestries, and the approach will be initially applied to asthma.

PI_NAMEs: PIVIDORI, MILTON  (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Acceleration;Affect;Algorithms;Area;Asthma;biobank;Biological;career;cell type;Clinic;Clinical;clinical care;Colorado;common treatment;Complex;Computing Methodologies;Databases;design;Detection;Dimensions;Disease;disease diagnosis;disease phenotype;disorder risk;Disparity;drug candidate;drug discovery;Drug Targeting;effective therapy;Environment;Environmental Exposure;Environmental Risk Factor;Etiology;FDA approved;flexibility;Gene Combinations;Gene Expression Profile;Generations;Genes;Genetic;Genetic Heterogeneity;genetic risk factor;Genetic study;Genetic Transcription;genetic variant;Genome;genome wide association study;Goals;Grouping;Heritability;Heterogeneity;high risk;Human;human disease;improved;Individual;individualized medicine;latent gene expression;Learning;Link;machine learning method;Maps;Medical Research;medical schools;Medicine;Mentors;Mentorship;method development;Methodology;Methods;Modality;Modeling;Molecular;Multiomic Data;Nature;Ontology;Outcome;Pathway interactions;Pattern;Pennsylvania;Performance;Peripheral;personalized medicine;Pharmaceutical Preparations;Pharmacology;Phase;Phenotype;Play;pleiotropism;polygenic risk score;Population;portability;precision medicine;Precision Medicine Initiative;Probability;profiles in patients;Prognosis;Property;recruit;Reduce health disparities;Regulation;Research;Research Personnel;Resources;risk prediction;risk stratification;Role;Systems Biology;Technology;Testing;Therapeutic;Tissues;Training;trait;Transcription Process;transcriptome;Translating;translational medicine;Universities;Validation;Variant;Work

PROJECT_TITLE: Computational approaches to characterize heterogeneity and improve risk stratification in complex disease phenotypes

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Our goals are to develop and use novel methodologies to understand the regulation of ion channels in the heart. By identifying new signaling pathways and interacting proteins, we hope, in the long-term, to develop new treatments for heart failure and arrhythmias.

PI_NAMEs: MARX, STEVEN O (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: A kinase anchoring protein;Ablation;Address;Adrenergic Agents;Adrenergic beta-Agonists;Affinity;Agonist;Alanine;Arrhythmia;ascorbate;Binding;Biochemical;Biotin;Cardiac;Cardiac Myocytes;Cells;Characteristics;Complex;Coupling;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;Dissociation;Doxycycline;Electrophysiology (science);Enzymes;Exercise;experience;fighting;Forskolin;Goals;Heart;Heart failure;in vivo;inhibitor;Ion Channel;Knock-in Mouse;Knockout Mice;Label;Macromolecular Complexes;Mass Spectrum Analysis;Measurement;Mediating;Methodology;Methods;Modeling;Molecular;Monomeric GTP-Binding Proteins;Mus;mutant;Mutate;Neighborhoods;new therapeutic target;novel;Peptides;Peroxidases;Phosphorylation;Phosphorylation Site;Physiological;Play;prevent;Probability;Process;protein activation;protein reconstitution;Proteins;Proteomics;recruit;Regulation;Resistance;response;Role;Sarcoplasmic Reticulum;Serine;Signal Pathway;Signal Transduction;Sympathetic Nervous System;Transgenic Mice;Transgenic Organisms;voltage

PROJECT_TITLE: Investigating Cardiac Ion Channels by Novel Methods

STUDY_SECTION: ESTA

STUDY_SECTION_NAME: Electrical Signaling, Ion Transport, and Arrhythmias Study Section[ESTA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Vaccine Related

PI_NAMEs: ESTES, MARY KOLB (contact)

PROJECT_TERMS: Address;Animal Model;Anti-viral Agents;Antigens;Apical;Attenuated;Bacteria;Bile Acids;Bile fluid;Binding;Biochemical;Biological;Biology;Biomimetics;Blood;Blood Group Antigens;burden of illness;Cell Culture Techniques;cell immortalization;Cell Line;cell type;Cells;Cellular biology;Ceramides;Cessation of life;Clinical;Clinical Trials;clinically relevant;co-infection;Colon;Communicable Diseases;Complex;Country;Cultured Cells;Data;Development;Disease;Engineering;Enteral;Enteric Nervous System;enteric virus infection;enteroaggregative Escherichia coli;Enterobacter;Enterocytes;Environment;epidemiology study;Epithelial Cells;Epithelium;Exhibits;first-in-human;flexibility;Functional disorder;Gastroenteritis;gastrointestinal;Gastrointestinal Diseases;gastrointestinal infection;Genetic;Genetic Transcription;Health Care Costs;Human;Immune;Immune Evasion;Immune response;Immune system;improved;Income;Infection;Interferons;Intervention;Intestines;Investments;Klebsiella;Knowledge;Laboratories;Life;Link;Low income;Mediating;Microbe;microbial community;microbiome;Modeling;Molecular;mortality;Mucosal Immune Responses;Mucous Membrane;multidisciplinary;Mus;Nerve;Neurons;Norovirus;Organ;Organoids;Outcome;pathogen;Pathogenesis;pathogenic bacteria;pathogenic virus;Physiological;Physiology;Play;Polysaccharides;pre-clinical;Predisposition;prevent;Production;Property;Research;response;Role;Rotavirus;Rotavirus disease;Rotavirus Infections;Rotavirus Vaccines;Route;Sampling;Serotonin;Severity of illness;Signal Pathway;Signal Transduction;Small Intestines;societal costs;success;Surface;technology development;Testing;tissue stem cells;translational model;translational potential;Translations;vaccine failure;vaccine response;Vaccines;Vesicle;Viral;Viral Gastroenteritis;virology;Virus;Virus Diseases;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Human Gastrointestinal Biomimetics for Enteric Viral Infections


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative  An expansion of a sequence of six DNA bases in the C9orf72 gene is the most common genetic cause for neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and the same mutation has been associated with other neurological diseases. Although these diseases are becoming an increasingly relevant public health challenge in our aging society, the mechanisms underlying most of these neurodegenerative conditions remain poorly understood. The biochemical, molecular, and genetic studies outlined in this proposal could lead to novel therapeutic interventions for these neurodegenerative diseases, for which effective treatments are still lacking.

PI_NAMEs: WANG, JIOU  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Aging;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;base;Binding;Biochemical;biological adaptation to stress;Brain;c9FTD/ALS;C9ORF72;Cells;Chromatin;chromatin remodeling;Clinical;DAXX gene;Defect;Dementia;Disease;DNA;DNA Binding;DNA Repeat Expansion;DNA-Binding Proteins;effective therapy;EIF-2alpha;Elements;Epigenetic Process;Equilibrium;Etiology;Expanded DNA Repeat;familial amyotrophic lateral sclerosis;Feedback;Foundations;frontal lobe;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;gain of function;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic approach;Genetic Diseases;Genetic Polymorphism;Genetic study;Genome;genome wide association study;genome-wide;Genomics;Goals;Human Genome;human old age (65+);Huntington Disease;Hybrids;infancy;insight;Intervention;Knowledge;Link;loss of function;Mediating;Microsatellite Repeats;Modeling;Molecular;Motor Neurons;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuromuscular Diseases;neurotoxicity;novel;novel strategies;novel therapeutic intervention;Nuclear;Nuclear Protein;Nucleotides;Older Population;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Phase;Phenotype;Phosphotransferases;Physical condensation;Process;Proteins;Public Health;Regulation;Reporting;Research;RNA;Role;Series;Short Tandem Repeat;Signal Transduction;Societies;sporadic amyotrophic lateral sclerosis;Stress;Structure;Temporal Lobe;theories;Toxic effect;Transcriptional Regulation;Translations;Untranslated RNA;Work

PROJECT_TITLE: Molecular Basis of Pathogenic Cascades in ALS/FTD Initiated from C9orf72 Hexanucleotide Repeat Expansion

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Chronic Kidney Disease is predominantly a result of initial injury to the glomerulus, the filtration system in the kidney. Dysregulated signaling between injured visceral and parietal epithelial cells is a major contributor to glomerular dysfunction and eventual kidney failure. In this research proposal, we aim to investigate the mechanisms mediating this cellular crosstalk in glomerular disease.

PI_NAMEs: HE, JOHN CIJIANG;MALLIPATTU, SANDEEP K (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Actins;Address;American;Attenuated;Binding;Cell Adhesion;Cell Cycle;Cell Cycle Checkpoint;Cell Differentiation process;cell type;Cellular Stress;ChIP-seq;Chronic Kidney Failure;comparison control;Cytoskeleton;Data;Development;differential expression;Differentiation Antigens;Disease;druggable target;Epithelial Cell Proliferation;Epithelial Cells;Failure;Family;Feedback;Filtration;Focal and Segmental Glomerulosclerosis;Functional disorder;Genes;GKLF protein;glomerulosclerosis;Goals;healthcare burden;Human;Hyperplasia;injured;Injury;Injury to Kidney;innovation;Kidney;kidney biopsy;Kidney Failure;Kidney Glomerulus;knock-down;Kruppel-like transcription factors;Laboratories;Lesion;Ligands;Maintenance;Mediating;Mediator;member;migration;Mitotic;Modeling;mouse model;Mouse Strains;Mus;mutant;Mutate;novel;Organoids;paracrine;Paracrine Communication;Parietal;Pathogenesis;Pathway interactions;Play;podocyte;postmitotic;Predisposition;prevent;Prevention;Proliferating;Proteomics;Rapidly Progressive Glomerulonephritis;receptor;Receptor Activation;Regulation;Renal glomerular disease;Reporting;Research Proposals;Role;Signal Induction;Signal Transduction;single nucleus RNA-sequencing;Specimen;Stat3 protein;System;Testing;therapeutic target;transcription factor;transcriptome sequencing;United States;Variant;Visceral;Zinc Fingers

PROJECT_TITLE: Mechanisms mediating podocyte-parietal epithelial cell crosstalk in proliferative glomerulopathies

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Aging;Lung;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Narrative With rapid growth of aging population, the annual incidence of aging related lung diseases is increasing. Our goal of this proposal is to test the hypothesis that ZIP8 deficiency in AEC2s which occurs with aging contributes to dysfunction of AEC2s progenitor cells leading to lung aging and restoration the components in ZIP8 mediated zinc metabolism may promote AEC2 renewal and slow down lung aging.

PI_NAMEs: LIANG, CAROL JIURONG (contact);NOBLE, PAUL WESLEY

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Acceleration;Acylation;age related;aged;Aging;aging population;aging related;Alveolar;alveolar epithelium;Anabolism;Biological Assay;Bleomycin;cell age;Cell Aging;Cell Compartmentation;cell injury;Cell Physiology;Cells;Characteristics;Complex;Coupled;Data;Disease;Elderly;Epithelial Cells;epithelial repair;epithelial stem cell;Epithelium;exhaust;exhaustion;Failure;Fibrosis;Flow Cytometry;Functional disorder;gain of function;genetic manipulation;Goals;healthspan;Homeostasis;Human;human old age (65+);idiopathic pulmonary fibrosis;Impairment;improved;In Vitro;in vivo;Incidence;injured;Injury;Intervention;Knock-in;Link;loss of function;Lung;Lung Diseases;lung injury;lung repair;Mediating;Metabolic;Metabolism;Molecular;mouse model;Mus;Natural regeneration;novel;old mice;Organoids;Pathway interactions;Phenotype;Population;Predisposition;premature;Premature aging syndrome;prevent;Process;Proteins;prototype;Pulmonary Fibrosis;rapid growth;Regulation;Rejuvenation;Reporting;restoration;Role;Signal Pathway;single-cell RNA sequencing;SIRT1 gene;Sirtuins;stem cell aging;stem cell division;stem cell function;stem cells;Testing;Zinc;Zinc supplementation;zinc-binding protein

PROJECT_TITLE: ZIP8-dependent Zinc Metabolic Regulation in Alveolar Progenitor Cell Aging and Fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-G(03)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Osteoporosis;Physical Injury - Accidents and Adverse Effects

ORG_CITY: CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Narrative Atypical femoral fractures (AFFs) are a rare but devastating side effect of long-term bisphosphonate (BP) treatment. The mechanisms driving BP associated AFFs remain elusive. The current collaborative grant seeks to investigate the contribution of bone matrix and bone remodeling to the development of AFFs.

PI_NAMEs: ANDERSEN, THOMAS LEVIN GEISER;ROSS, RYAN DEE (contact);WALLACE, JOSEPH MICHAEL

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Address;Affect;Alendronate;Automobile Driving;Awareness;Biological;bisphosphonate;bone;bone fatigue;Bone Matrix;Bone remodeling;Cell Density;Cells;Compensation;Contralateral;Data;Depressed mood;Development;Diet;Fatigue;Femoral Fractures;Formulation;Fracture;Functional disorder;Grant;Holidays;Ibandronate;Impairment;improved;Individual;innovation;interest;Kinetics;Laboratories;Lactation;Life;Long-Term Effects;Low Prevalence;medication compliance;Modeling;Molecular Structure;novel;Operative Surgical Procedures;osteoblast proliferation;Osteoblasts;Osteoclasts;Osteogenesis;Osteoporosis;osteoprogenitor cell;Pathogenesis;Patients;Pharmaceutical Preparations;Phase;Population;Pre-Clinical Model;Predisposition;Prevention;Prevention strategy;Process;Property;Qualifying;Radiology Specialty;Raloxifene;Rattus;Reporting;Research;response;Risedronate;Risk;Role;Secondary to;Selective Estrogen Receptor Modulators;side effect;Site;skeletal;Skeleton;Surface;Testing;Tissues;treatment strategy;Work;Zoledronate

PROJECT_TITLE: How bisphosphonates affect bone matrix and remodeling: implications for atypical femoral fractures

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Pediatric;Vaccine Related

PI_NAMEs: PIEDRA, PEDRO A (contact)

PROJECT_TERMS: 2019-nCoV;3-Dimensional;ACE2;adaptive immune response;Address;Adult;Advanced Development;Age;Air;airway epithelium;Animal Model;Animals;Apical;Automobile Driving;Biomimetics;biosafety level 3 facility;Bronchoalveolar Lavage;Cells;Cellular Immunity;Child;Childhood;Circulation;Clinical Trials;Coculture Techniques;Collaborations;Communities;Complex;Coronavirus;cost;COVID-19 pandemic;COVID-19 vaccine;cytokine release syndrome;Data;Deglutition;Development;Disease;Disease Pathway;Donor Selection;Engineering;experience;Female;gastrointestinal;Gastrointestinal Diseases;gastrointestinal symptom;gastrointestinal system;Gastrointestinal tract structure;Generations;gut-lung axis;Heparan Sulfate Proteoglycan;Human;human disease;Humoral Immunities;Immune;Immune response;Immunity;immunoprophylaxis;Infection;Inflammation;injured airway;Innate Immune Response;International;Intestines;Kinetics;Licensing;Liquid substance;Lung;male;Modeling;Molecular;Mucous Membrane;Nasal Epithelium;Nasal Lavage Fluid;neutralizing antibody;nonhuman primate;Nose;novel;Organoids;pathogen;Pathogenesis;Pathway interactions;Positioning Attribute;Pre-Clinical Model;Proxy;pulmonary symptom;receptor;Research;respiratory;respiratory challenge;Respiratory Disease;respiratory infection virus;respiratory pathogen;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Tract Infections;respiratory virus;Role;Safety;sex;Site;stem cells;Study models;System;Therapeutic;Time;Tropism;vaccine candidate;vaccine evaluation;Vaccines;Viral;Viral Pathogenesis;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Human Airway Biomimetics for RSV and Other Respiratory Viruses


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The current epidemic of e-cigarette use among adolescents is of great concern, as e-cigarette use can lead to nicotine addiction and associated negative consequences. The current project will develop and test prevention messages that aim to effectively discourage adolescents from using e-cigarettes. This research will contribute to decreased e-cigarette use and a reduction in associated negative consequences among adolescents.

PI_NAMEs: NOAR, SETH MICHAEL (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: 2 arm randomized control trial;addiction;Address;Adolescence;Adolescent;Adult;Advertisements;Age;aged;arm;Attention;attentional control;Behavior;Belief;Cellular Phone;Centers for Disease Control and Prevention (U.S.);cigarette smoke;cigarette smoking;Cognitive;cognitive interview;Communication;Devices;Effectiveness;Electronic cigarette;electronic cigarette use;electronic vape;Epidemic;evidence base;experimental study;Focus Groups;follow up assessment;follow-up;Foundations;Funding;Harm Reduction;health communication;Industry;Intervention;Interview;Knowledge;Learning;Literature;Measures;Moods;Multimedia;negative affect;Nicotine;Nicotine Dependence;nicotine exposure;Outcome;Participant;Persons;Pilot Projects;Population;population based;Predisposition;prevent;Prevention;Prevention Research;primary outcome;Probability;Probability Samples;Protocols documentation;Randomized, Controlled Trials;reduce tobacco use;Research;Research Priority;response;Risk;Sampling;Science;secondary outcome;Services;Smoker;Social Desirability;Social Interaction;social norm;Surgeon;Teenagers;Testing;Text Messaging;Tobacco;Tobacco Control Research;tobacco products;Tobacco use;tool;United States Food and Drug Administration;vaping;Vulnerable Populations;willingness;Work;Youth

PROJECT_TITLE: Impact of e-cigarette prevention messages on adolescents


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Serious Mental Illness

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This project explores the potential effect of ketamine, an N-methyl-D-aspartate glutamate receptor (NM DAR) antagonist, to enhance fear memory extinction and reconsolidation using an intensive 4-day exposure therapy. Together with traditional symptoms reduction approach we combine neuroimaging and psychophysiology biomarkers to further validate the intervention. The work will facilitate the development of shorter and more robust treatment for PTSD.

PI_NAMEs: HARPAZ-ROTEM, ILAN  (contact)

PROGRAM_OFFICER_NAME: TUMA, FARRIS KEITH

PROJECT_TERMS: Acceleration;Affective;Aftercare;Amygdaloid structure;Anesthetics;Animals;anti-depressive agents;antidepressant effect;Atrophic;Back;Basic Science;Biological Markers;Brain;Brain region;Brain-Derived Neurotrophic Factor;Cell Proliferation;Chronic Post Traumatic Stress Disorder;Chronic stress;Classification;Clinical;Clinical assessments;clinical effect;Cognitive Therapy;Control Groups;Corpus striatum structure;Cues;Data;depressive symptoms;design;Development;Devices;Diagnosis;Dose;Double-Blind Method;Dropout;effective intervention;Effectiveness;efficacy evaluation;Excitatory Amino Acid Antagonists;experience;Exposure to;Extinction;FDA approved;fear memory;Fright;Functional disorder;Galvanic Skin Response;Harvest;Hippocampus;Human;Impairment;improved;in vivo;Individual;Industrialization;Infusion procedures;insight;Insula of Reil;interest;Intervention;Ketamine;Learning;Link;Measures;meetings;Memory;Midazolam;Moods;N-Methylaspartate;neural;Neurobiology;neurogenesis;neuroimaging;neuromechanism;Neuronal Plasticity;Neurosciences;novel;Participant;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Placebo Control;placebo group;Placebos;Post-Traumatic Stress Disorders;Prefrontal Cortex;premature;Process;Psychophysiology;Psychotherapy;randomized, controlled study;reduce symptoms;Reporting;response;Selective Serotonin Reuptake Inhibitor;severe mental illness;Startle Reaction;Structure;success;symptomatology;Symptoms;synaptogenesis;Testing;Therapeutic Intervention;therapy resistant;Time;Trauma;Treatment outcome;treatment response;treatment trial;treatment-resistant depression;Visit;Work

PROJECT_TITLE: Using Ketamine to enhance memory reconsolidation and extinction of overgeneralized fear in individuals diagnosed with PTSD


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE This project will measure levels of a brain nicotinic receptor in people exposed to trauma, half of them with PTSD. Relationships of these receptors with PTSD symptoms and fear learning will be investigated. The findings will advance the basic neuroscience understanding of factors contributing to distinct symptoms, informing future development and evaluation of pharmacotherapies for people with PTSD.

PI_NAMEs: HILLMER, ANSEL  (contact)

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: Acetylcholine;Address;Agonist;alpha-bungarotoxin receptor;Amygdaloid structure;Anti-Anxiety Agents;anxious;Arousal;Basic Science;Behavioral;Brain;Brain region;cholinergic;Chronic Post Traumatic Stress Disorder;Chronic stress;clinical development;clinically relevant;Computer Models;Data;density;Development;diagnostic criteria;Dimensions;Disease;Evaluation;Exhibits;Extinction;Fright;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Hippocampus;Human;human study;Image;Impairment;improved;Individual;Learning;learning extinction;Link;Maps;Measures;Mediating;meetings;memory process;Molecular Target;multidisciplinary;multimodality;neural;neural circuit;neuroimaging;neuronal circuitry;Neurosciences;Nicotinic Receptors;Participant;Persons;Pharmacological Treatment;Pharmacotherapy;physiologic model;Positron-Emission Tomography;Post-Traumatic Stress Disorders;pre-clinical;Pre-Clinical Model;Prefrontal Cortex;Process;Public Health;radioligand;receptor;recruit;Reporting;response;Role;Sampling;Sampling Studies;Scanning;Severities;Signal Transduction;symptom cluster;Symptoms;Therapeutic;therapeutic development;Translating;trauma exposure

PROJECT_TITLE: Neuroimaging Cholinergic Mechanisms of Fear Extinction in PTSD

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome

PI_NAMEs: MARESSO, ANTHONY W (contact)

PROJECT_TERMS: Ablation;Address;Adherence;Affect;antagonist;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Apical;Bacterial Infections;Bacteriophages;Binding;Biological Models;Biology;Biomedical Engineering;Biomimetics;Biota;Cell Physiology;Cells;Child;Coculture Techniques;Collection;Colon;Communicable Diseases;Complex;Cues;cytotoxicity;Data;Diarrhea;Disease;Duodenum;Ecosystem;Elements;Enteral;enteric pathogen;enteroaggregative Escherichia coli;Environment;Epithelial Cells;Equilibrium;Escherichia coli;Escherichia coli Infections;Etiology;Extracellular Matrix;Funding;gastrointestinal;gastrointestinal infection;Gastrointestinal tract structure;Growth;gut microbiota;Heparan Sulfate Proteoglycan;heparin proteoglycan;Human;Hybrids;ileum;Immune;Immune response;Immunocompromised Host;Immunologics;Infection;Infection prevention;Inflammation;Inflammatory;Inpatients;Integration Host Factors;intestinal epithelium;Intestinal Mucosa;Intestines;jejunum;Knowledge;Measures;Mediating;Medicine;microbiota;Modeling;Molecular;Molecular Profiling;Mucous Membrane;Multi-Drug Resistance;National Institute of Allergy and Infectious Disease;Nature;novel;Organoids;pathogen;Pathogenesis;Patients;Physiological;Physiology;Polysaccharides;Predisposition;Program Description;Property;receptor;Recording of previous events;Reporting;Research;response;Seminal;shear stress;Surface;System;Therapeutic;Tissues;Tropism;Vaccines;Virulent;Work

PROJECT_TITLE: Human Gastrointestinal Biomimetics for Enteric Bacterial Infections


NIH_SPENDING_CATS: Biotechnology;Genetics;Physical Injury - Accidents and Adverse Effects

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE MicroRNAs (miRNAs) are small non-coding RNA molecules that function to suppress synthesis of a number of proteins in the cell. We have identified miRNA candidates (miR-138 and miR-181a/b-1) that regulate bone formation. These studies will determine the mechanism by which these miRNAs control bone production and address the therapeutic potential of modulating their activity in vivo to attempt to enhance bone fracture repair or inhibit abnormal bone formation (heterotopic ossification).

PI_NAMEs: MCALINDEN, AUDREY  (contact)

PROJECT_TERMS: achilles tendon;Address;Affect;Biological Assay;bone;Bone callus;bone fracture repair;bone healing;bone repair;Cell Differentiation process;Cell Physiology;cell type;Cells;Chondrocytes;Chondrogenesis;Chromosome 1;clinically relevant;Computer Analysis;Data;Defect;design;Development;differential expression;differentiation in vitro;Disease;disease model;Down-Regulation;Embryo;Enzymes;Epigenetic Process;Epiphysial cartilage;FOXO1A gene;Fracture;Genes;Genetic Transcription;Goals;Heterotopic Ossification;Human;In Vitro;in vivo;inhibitor therapy;Knock-in Mouse;long bone;Mediating;Messenger RNA;Metabolic;MicroRNAs;mineralization;Mitochondria;mitochondrial metabolism;Modeling;mouse model;novel;novel strategies;Orthopedics;Osteogenesis;overexpression;Oxidative Phosphorylation;Oxygen Consumption;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;Physiologic Ossification;PI3K/AKT;Population;Process;Production;progenitor;Protein Biosynthesis;Proteins;Publishing;pyruvate dehydrogenase;Pyruvate Dehydrogenase Complex;pyruvate dehydrogenase kinase 4;Regulation;repaired;Reporting;Respiration;Role;Signal Transduction;skeletal;systemic inflammatory response;Testing;Therapeutic;therapeutic target;Transcription Coactivator;transcriptome sequencing;Translating;Translations;Ulna Fractures;Untranslated RNA

PROJECT_TITLE: MicroRNA regulation of bone formation and repair


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: COLUMBIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The proposed research examines the genetic processes that underlie complex biological differences among organisms. Examining the genetic basis of organismal differences in a variety of study systems may yield novel findings on how these differences arise and are maintained over evolutionary time, an issue of fundamental importance for identifying genetic mechanisms underlying human disease.

PI_NAMEs: WESSINGER, CARRIE  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: Quantitative genetics and population genomics of repeated complex trait evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


NIH_SPENDING_CATS: Asthma;Biotechnology;Lung;Pediatric

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE  Clinical interventions such as supplemental oxygen and CPAP for babies born prematurely predispose to chronic lung diseases such as wheezing and asthma which remain major health problems throughout childhood and beyond. The primary goal of this proposal is to understand how the initial exposure to oxygen and CPAP affects structure and function of developing airways even after these interventions are stopped, with the focus on novel piezo channels that sense the mechanical stretch imposed by CPAP on the airway. We believe that piezo channels can then promote airway hypercontractility and excessive growth of airway cells, all resulting in a thicker, more reactive airway while the baby and the lungs are growing.

PI_NAMEs: PRAKASH, Y. S.  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Acute;Adult;Adult asthma;Affect;Agonist;airway hyperresponsiveness;airway remodeling;Alveolar;antagonist;Asthma;beta catenin;Biochemical;Birth;Bladder;Blood Vessels;Breathing;Cations;Cell Proliferation;cell type;Cells;Childhood;Chronic;Chronic lung disease;Clinical;clinical application;clinically relevant;clinically significant;Continuous Positive Airway Pressure;critical period;Cytoskeleton;Data;Development;Elements;Embryo;Exposure to;expression vector;Extracellular Matrix;fetal;Fetal Viability;Fetus;Fibrosis;glycogen synthase kinase 3 beta;Goals;Growth;Health;Histology;Human;Hyperoxia;Image;In Vitro;Infant;inhibitor;Injury;Intervention;Knockout Mice;laser capture microdissection;Link;Long-Term Effects;Lung;lung development;Mechanics;Mediating;Modeling;Molecular;Motility;mouse model;Mus;Neonatal;neonatal mice;Newborn Infant;normoxia;Nose;novel;Oxygen;Pathway interactions;Periodicity;Phenotype;Phosphorylation;Piezo ion channels;Pregnancy;premature;Premature Birth;pressure;Proliferating;Recovery;respiratory;respiratory morbidity;respiratory smooth muscle;response;rho;Role;Signal Transduction;Slice;Small Interfering RNA;Smooth Muscle;Smooth Muscle Myocytes;Source;Stretching;Structure;supplemental oxygen;System;Techniques;Testing;tool;Touch sensation;Traction Force Microscopy;Transducers;Wheezing;wound healing

PROJECT_TITLE: Neonatal Modulation of Airway Contractility

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Recent preclinical studies demonstrated that FLASH radiation therapy at ultrahigh dose rates can substantially reduce normal tissue toxicities while maintaining the same tumor response as seen following conventional radiation therapy. As an absolute prerequisite, ultrafast time-resolved FLASH dosimetry is extremely challenging and currently not feasible with commercially available dosimetry methods. The proposed first-of-its- kind ultrafast dosimetry system will provide clinics worldwide a unique, accurate, and robust solution to the research, implementation, and quality assurance of precision FLASH radiation therapy.

PI_NAMEs: LI, HAROLD HUI (contact);ROYON, CHRISTOPHE

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TITLE: Ultrafast FLASH radiation therapy dosimetry

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT SUMMARY Alzheimer's disease (AD) affects half the US population over the age of 85 and despite decades of research, reliable treatments for AD have not been found. The overarching goal of our proposal is to generate multiscale genomics (gene expression and epigenome regulation) data at the single cell level and perform fine mapping to detect and validate causal variants, transcripts and regulatory sequences in AD. The proposed work will bridge the gap in understanding the link among the effects of risk variants on enhancer activity and transcript expression, thus illuminating AD molecular mechanisms and providing new targets for future therapeutic development.

PI_NAMEs: ROUSSOS, PANAGIOTIS  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;Alzheimer's Disease;Alzheimer's disease risk;Appearance;Architecture;ATAC-seq;Autopsy;Bioinformatics;Biological;Biological Assay;Brain;brain tissue;causal variant;Cell Nucleus;cell type;Cells;Cellular Assay;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chimeric Proteins;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collection;Communities;Data;Dementia;Development;Disease;disease mechanisms study;Disease Progression;Dissection;Enhancers;entorhinal cortex;epigenome;Evaluation;Fluorescence;Future;Gene Expression;Gene Expression Profiling;gene regulatory network;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic Variation;Genome;genome wide association study;genome-wide;genomic signature;Genomics;Genotype;Goals;Grant;Human;Impaired cognition;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;insight;Late-Onset Disorder;Lesion;Libraries;Link;Maps;Mediating;Microglia;Molecular;Molecular Disease;molecular marker;multidisciplinary;multimodality;Neurons;neuropathology;non-genetic;novel strategies;Nuclear;Nucleic Acid Regulatory Sequences;Outcome;Output;Pathogenesis;Phenotype;Population;programs;progressive neurodegeneration;promoter;Proxy;Regulation;Regulator Genes;Regulatory Element;Reporter;Research;Risk Factors;risk variant;Sampling;Secondary to;single nucleus RNA-sequencing;single-cell RNA sequencing;Sorting;Superior temporal gyrus;Symptoms;Testing;therapeutic development;three dimensional structure;Transcript;transcriptome;transcriptome sequencing;Untranslated RNA;Variant;Work

PROJECT_TITLE: Higher Order Chromatin and Genetic Risk for Alzheimer's Disease

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: AT

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Dietary Supplements;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Natural Products;Nutrition;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_NAME: CUNY GRADUATE SCH AND UNIV CTR

PHR: Project narrative This project will provide scientifically validated information on plants used for gynecological conditions by Caribbean women in New York City as well as other women globally who use these plants. Cross-cultural comparisons of women’s health practices within the larger Caribbean community in NYC will offer scientific feedback to these communities about their cultural healing traditions while contributing to the international dialogue on intercultural health. The results of this study will also be relayed to doctors and medical students to promote cultural competency through the Car-Lo E2 program at the New York Botanical Garden as well as a bilingal monograph that will be given back to the Caribbean community in NYC.

PI_NAMEs: VARDEMAN, ELLA  (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Address;Anti-Bacterial Agents;antimicrobial;Antimicrobial Effect;Back;Bacteria;Bixa;Botanica;Botanicals;Caribbean region;chemical fingerprinting;Chemicals;Cities;Coculture Techniques;Collaborations;Commerce;Communities;cost;Country;COVID-19 pandemic;Cross-Cultural Comparison;cultural competence;Data;Deposition;Disease;Effectiveness;Environment;Ethnobotany;ethnomedicine;Ethnopharmacology;Evaluation;Feedback;Fractionation;Future;Gardnerella vaginalis;Growth;Gynecologic;Haitian;healing;Health;Home;Immigrant;improved;In Vitro;Infection;insight;International;Interview;Investigation;Jatropha;Knowledge;Laboratories;Laboratory Study;Lactobacillus;Literature;Marketing;Measures;Medical;Medical Students;Medicinal Plants;Medicine;member;metabolomics;Methodology;Methods;microbiota;Monograph;Natural Products;New York;New York City;outreach;pathogenic bacteria;pathogenic microbe;Pathogenicity;Perception;Persons;Phytochemical;Plant Extracts;Plant Leaves;Plant natural product;Plants;Population;Preparation;Prickly Poppy;programs;Property;Public Health;Reporting;Research;Self Medication;Sexually Transmitted Diseases;Specimen;Statistical Data Interpretation;Surveys;Taxonomy;Testing;Tissues;Traditional Medicine;United Nations;Vagina;vaginal infection;vaginal microbiota;Validation;Variant;Woman;Women's Health;World Health Organization

PROJECT_TITLE: Ethnopharmacology of plants used by Haitians in New York City forwomen’s health


NIH_SPENDING_CATS: Immunotherapy;Microbiome

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Recent studies strongly suggest that molecules originating from symbiotic microbes can actively contribute to host immune development and regulation, nonetheless, the study of structures and functions of bioactive molecules is still lacking. Herein, we aim to understand how gut symbiont-derived lipids (BfaGCs) are recognized by the specific host protein CD1d. We will investigate how the CD1d-lipid complex can induce immunomodulatory functions of a specific subset of T cells (natural killer T cells) and can protect the host from excessive inflammation. This project will provide valuable knowledge on the host-microbiota interaction mechanism and will enable future development of immunotherapeutics from symbiotic microbiota-derived metabolites.

PI_NAMEs: OH, SUNGWHAN F (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Affinity;Agonist;alpha-galactosylceramide;Antigen-Presenting Cells;Antigens;Bacteroides fragilis;Biological;Cell Differentiation process;Cell Physiology;Chemical Structure;Chemicals;Colitis;Colon;Colonic inflammation;commensal microbes;Complex;Cytotoxic T-Lymphocytes;density;Development;Diglycerides;Disease;Disease susceptibility;Future;host microbiota;Human;Immune;Immune system;immunoreaction;immunoregulation;Immunotherapeutic agent;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;interest;Investigation;Knowledge;Life;Ligands;lipidomics;Lipids;Mediating;MHC Class I Genes;Microbe;microbiota;microbiota metabolites;Molecular;novel;Oral Administration;Organic Synthesis;pathogen;Phenotype;Population;Proliferating;Proteins;prototype;Regulation;Reporting;response;Signal Induction;Signal Transduction;Sphingomyelins;Structure;Structure-Activity Relationship;symbiont;System;T cell response;T-Cell Proliferation;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;TCR Activation;Variant

PROJECT_TITLE: Gut symbiotic microbiota-derived CD1d ligands and their immunomodulatory mechanisms

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Social Determinants of Health

PHR: Project Narrative: Older sexual and gender minority (SGM) patients are at risk for receiving  inequitable end-of-life care; those with Alzheimer’s disease and related dementias (ADRD) are  at particularly high risk. Failure to collect and integrate sexual orientation and gender identity  (SOGI) data to identify patients’ informal support systems may have adverse health  consequences for SGM older adults, particularly for those dependent on informal caregivers to  provide in-home support and assist with activities of daily living. The goal of this K01 is develop  a novel training for hospice staff in person-centered communication that includes SOGI data  collection to promote authentic end-of-life care for SGM patients and their caregivers.

PI_NAMEs: CANDRIAN, CAREY B (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Activities of Daily Living;Address;Adult;advanced disease;Affect;Aging;Alzheimer's disease patient;Alzheimer's disease related dementia;Attention;Back;Behavior;behavior change;Bioethics Consultants;bullying;care delivery;Caregivers;Caring;Child;Clinical;Clinical Trials;Colorado;Communication;communication behavior;Communities;community advisory board;Data;Data Collection;design;Diagnosis;Disclosure;Discrimination;Disease;Education;Educational Intervention;Educational process of instructing;end of life;end of life care;Enrollment;Environment;Ethics;Evaluation;experience;Failure;Family;Focus Groups;Fostering;Foundations;Fright;Future;Gender Identity;gender minority community;gender minority group;Goals;Grief reaction;Guidelines;Health;health care disparity;health communication;health disparity;high risk;Home;hospice environment;Hospitals;improved;Inequity;informal caregiver;informal support;insight;intersectionality;Intervention;Intervention Trial;K-Series Research Career Programs;Lived experience;Medical;medical schools;member;Mentors;Methods;minority patient;novel;Nurses;older adult;Outcome;participant enrollment;Patients;perceived discrimination;Perception;person centered;Persons;physical abuse;pilot test;Play;Policies;Positioning Attribute;preference;Process;professor;Recommendation;Reduce health disparities;Reporting;Research;Research Personnel;Respondent;Risk;Role;satisfaction;Sex Orientation;Sexual and Gender Minorities;shared decision making;social stigma;Source;Statistical Methods;Stress;Structure;Support System;Surveys;Testing;therapy development;Training;Training Activity;Universities;Verbally abusive behavior;virtual;Work

PROJECT_TITLE: A novel intervention to improve care for older sexual and gender minority (SGM) adults  with serious illness and especially those with Alzheimer’s Disease and Related Dementias  (ADRD)

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Cardiovascular diseases such as heart failure and arrhythmia are the leading cause of death in the U.S. While mathematical modeling has proven to be a useful tool in studying intracellular Ca2+ signaling in cardiomyocytes, current models fail to account for changes in Ca2+ release channel expression and subcellular remodeling that occur in heart failure. We propose development and experimental validation of new models of intracellular Ca2+ release that more accurately reflect Ca2+ signaling in failing ventricular cardiomyocytes.

PI_NAMEs: JONES, DEANALISA  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Address;Affect;Arrhythmia;Behavior;Calcium;Calcium Signaling;Cardiac Myocytes;Cardiovascular Diseases;Cause of Death;Cell membrane;Cell Physiology;cell type;Cells;Cessation of life;Clinical;Computer Models;Coupling;Cytoplasm;Data;design;Development;Disease;Event;Foundations;Frequencies;Geometry;Heart Atrium;Heart failure;Heterogeneity;In Vitro;Individual;insight;Link;mathematical model;Measures;Mediating;Membrane;Minor;Modeling;multi-scale modeling;Muscle Cells;nanometer;novel;Outcome Measure;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Physiological;Play;predictive modeling;prevent;Probability;Process;Property;Rattus;receptor;receptor expression;Risk;Role;Ryanodine Receptor Calcium Release Channel;Signal Transduction;Site;spatiotemporal;sudden cardiac death;Sum;Testing;tool;Training;Validation;Ventricular;Ventricular Arrhythmia;Visualization;voltage

PROJECT_TITLE: Modeling the spatiotemporal properties of crosstalk between RYR-mediated and IP3R-mediated calcium signaling in cardiac myocytes


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hematology;Racial and Ethnic Minority Health Research

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Six million Americans suffer with atrial fibrillation (AF), a heart rhythm abnormality that is a major risk factor for stroke. Despite this, only 60% of eligible AF patients receive treatment, and this gap is even larger for African- Americans with their use ranging 10-22% less compared to Whites and Hispanics. Within the context of an ongoing collaboration between two large learning health systems, we propose to develop and test the impact of a storytelling intervention in African-Americans through a pilot and feasibility trial in African-Americans not on AC and measure recruitment and retention rates as well as fidelity of and satisfaction with our storytelling intervention.

PI_NAMEs: KAPOOR, ALOK  (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: absorption;Address;Adherence;African American;African American population;American;Anticoagulation;Atrial Fibrillation;Awareness;behavior change;Belief;Cardiology;Collaborations;Communication;Communities;comparative effectiveness;Complex;Coping Skills;Development;Eligibility Determination;experience;Exploratory/Developmental Grant;falls;feasibility trial;Film;Focus Groups;Future;Guidelines;health belief;Health system;heart rhythm;Hemorrhage;Hispanic Populations;hypertension control;improved;Individual;Institution;instrument;Intervention;Interview;Learning;Lifelong disability;Manuals;Massachusetts;Measures;meetings;Michigan;Modeling;National Institute on Minority Health and Health Disparities;operation;Oral;Participant;Patients;Phase;pilot trial;Professional Organizations;Protocols documentation;Provider;Randomized;randomized trial;Recommendation;Recording of previous events;recruit;Reporting;Research;Research Project Grants;retention rate;Risk Factors;risk perception;satisfaction;Self Efficacy;Site;Specialist;Stroke;stroke risk;Testing;Time;Transportation;trend;Trust;Universities;usability;Videotape;web site;Work

PROJECT_TITLE: Storytelling for Reducing Gap in AC Use in African Americans with Atrial Fibrillation

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Physical function limitations among older cancer survivors is associated with multiple negative health outcomes, representing a critical problem in public health. This study will implement and assess the efficacy of the first online dietary and resistance training intervention to improve older cancer survivors’ physical function and improve associated health outcomes (muscle strength, dietary quality, health-related quality of life, self-efficacy, weight management). The expected outcomes of this study will inform the development of large-scale trials and have implications that can lead to efficacious behavioral interventions in health promotion for older cancer survivors.

PI_NAMEs: KROK-SCHOEN, JESSICA L. (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;acceptability and feasibility;Accounting;Address;Adherence;adherence rate;Age;Aging;Arthritis;behavior change;Behavior Therapy;Calories;Cancer Intervention;Cancer Patient;Cancer Survivor;Cancer Survivorship;Clinical;comorbidity;comparison control;Comprehensive Cancer Center;Consumption;Control Groups;Counseling;Coupled;COVID-19 pandemic;Data;design;Development;Diet;dietary;Dietary intake;Dietary Intervention;Dietitian;Education;Educational Intervention;Educational Materials;effective intervention;effectiveness evaluation;efficacy evaluation;Exercise;exercise intervention;exercise regimen;experience;experimental group;falls;Fatigue;follow-up;Functional impairment;Geriatrics;Goals;good diet;Health;Health behavior;Health Care Costs;Health Promotion;health related quality of life;Heart Diseases;Heart Rate;high risk;human old age (65+);Impairment;improved;Incidence;innovation;insight;Intake;Intervention;intervention effect;intervention participants;Knowledge;Lead;Lung Diseases;Malignant Neoplasms;Mission;mortality;multiple chronic conditions;muscle form;Muscle Proteins;muscle strength;Muscular Atrophy;novel;novel strategies;Nutritional;Obesity;Ohio;older adult;online delivery;Outcome;Outcome Study;Pain;Participant;peer;Physical assessment;Physical Function;Population;post intervention;Predisposition;Prevalence;prevent;Process;programs;Protein Biosynthesis;protein intake;Proteins;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Recording of previous events;recruit;Research;resistance exercise;retention rate;Risk;Risk Reduction;Sampling;sarcopenia;SARS-CoV-2 exposure;Science;Scientist;Self Efficacy;survivorship;Testing;Training and Education;Universities;waist circumference;Weight;Weight maintenance regimen;Work

PROJECT_TITLE: E-PROOF: E-intervention for Protein Intake and Resistance Training to Optimize Function

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: OSWEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: COLLEGE AT OSWEGO

PHR: PROJECT NARRATIVE Aging is associated with deficits in cognitive control, an executive function central to mental health. We propose new experiments to distinguish the psychological and neural processes underlying cognitive control dysfunction in older adults including those with mild cognitive impairment. The results will contribute to our understanding of the effects of aging on cognitive function and may help advance research of many age-related clinical conditions including Alzheimer’s disease.

PI_NAMEs: HU, SIEN  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Address;Age;age effect;age related;age related changes;age-related disease;Aging;aging hippocampus;Alzheimer's Disease;Anterior;Area;base;Behavioral;Brain;cardiovascular health;Caring;Cerebrum;Clinical;Cognitive aging;cognitive control;cognitive function;cognitive process;Cues;daily functioning;Data;Decision Making;Deterioration;diagnostic development;diagnostic tool;executive function;Experimental Designs;experimental study;Functional disorder;Functional Magnetic Resonance Imaging;Goals;gray matter;Health;healthy aging;hippocampal atrophy;hippocampal subregions;Hippocampus;Impaired cognition;Impairment;Individual;innovation;Intervention;Learning;Letters;Literature;Maps;men;Mental Health;mild cognitive impairment;morphometry;Motor;Motor output;neocortical;neural;neuropsychiatry;Neurosciences;older adult;Performance;Play;Prefrontal Cortex;Probability;Process;psychologic;Quality of life;Reaction Time;Reporting;Research;response;Response to stimulus physiology;Role;sex;Signal Transduction;Stimulus;Task Performances;Variant;Withdrawal;Woman

PROJECT_TITLE: Aging hippocampus and cognitive control in health and MCI


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Narrative Many individuals living in endemic areas are partially protected against malaria but the mechanisms underlying this lower susceptibility remain poorly understood, especially as they relate to Plasmodium vivax. We propose to use novel genomic approaches, including the characterization of parasite gene expression at a single cell level, to study how P. vivax parasites invade and grow within red blood cells in Cambodian patients. Our studies will generate novel insights on the parameters regulating P. vivax blood stage infections and provide immediately-relevant clinical information to better control this important human pathogen.

PI_NAMEs: SERRE, DAVID  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: acquired immunity;Antibodies;Antigens;Area;asexual;Binding;Biology;Blood;Blood specimen;Cambodia;Cambodian;Cell Cycle Progression;Cell Physiology;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;clinically relevant;Collaborations;Complement;cytokine;Data;density;Development;DNA;Erythrocytes;experience;experimental study;Exposure to;Foundations;G6PD gene;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic Polymorphism;genome-wide;Genomic approach;Genotype;Geographic Distribution;Glucosephosphate Dehydrogenase Deficiency;Growth;Hemoglobin;Hemoglobinopathies;Human;human pathogen;Immune;Immunity;improved;In Vitro;in vivo;Individual;Infection;Inflammation;insight;Invaded;Leukocytes;Malaria;Malaria Vaccines;Measures;Molecular;novel;parasite invasion;Parasitemia;Parasites;Participant;Pathway interactions;patient subsets;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Plasmodium;Plasmodium vivax;Population;Predisposition;prevent;Process;Proteins;Regulation;resilience;response;RNA;Role;Sampling;Serology;Severity of illness;Sex Differentiation;single-cell RNA sequencing;Solid;Symptoms;Testing;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;vaccine trial;Variant;Vivax Malaria;Whole Blood

PROJECT_TITLE: Host and parasite factors influencing P. vivax RBC invasion and asexual development

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: NEUROSURGERY

PHR: Adaptive neurotechnologies interact with the nervous system to provide new therapies for a wide variety of neurological disorders. The development of these technologies is complex, time-consuming, and costly. In this project, we propose to provide and to widely disseminate a software resource that greatly simpliﬁes the development process, and thereby accelerates the realization of new adaptive neurotechnologies that will improve diagnosis and treatment of many devastating neurological disorders.

PI_NAMEs: BRUNNER, PETER  (contact)

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: Acceleration;Achievement;Address;Adopted;Adoption;Area;Behavior;Biomedical Engineering;Central Nervous System;Clinical;collaborative environment;Communication;Complement;Complex;computer science;Computer software;Consumption;cost;Custom;Development;Diagnosis;Disease;Documentation;Educational Curriculum;Engineering;experimental study;Feedback;Fostering;Funding;Impairment;improved;Injury;interest;interoperability;Investigation;knowledge integration;Laboratories;Life;Measures;multidisciplinary;Muscle;Nervous System;Nervous System Disorder;Nervous System Physiology;Neurosciences;neurotechnology;novel;novel therapeutics;Output;Peer Review;Persons;Process;Programming Languages;Protocols documentation;Publications;Recovery;Research;research and development;Research Personnel;Resources;Scientist;Signal Transduction;Site;Software Tools;Spinal cord injury;Stroke;success;System;Systems Development;Teaching Materials;Technology;technology development;Testing;Time;Training;Translations;United States National Institutes of Health;Universities;verification and validation;Work

PROJECT_TITLE: BCI2000: Software Resource for Adaptive Neurotechnology Research


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Narrative Dementia with Lewy bodies and Parkinson’s disease are characterized by the a-synuclein accumulation, but the downstream pathophysiological mechanisms are not known. Our data indicate that a-synuclein perturbs lysosomal degradation by blocking the transport of hydrolases to the lysosome. Here, we examine the mechanism of this process and develop novel methods to restore lysosomes in these disorders.

PI_NAMEs: MAZZULLI, JOSEPH R (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: age related neurodegeneration;alpha synuclein;Biogenesis;Biological;Biology;Brain;Cell Death;Cell Physiology;Cells;Clinic;clinical development;Data;Dementia with Lewy Bodies;Disease;Documentation;efficacy testing;Endoplasmic Reticulum;endoplasmic reticulum stress;Enhancers;Failure;Foundations;Functional disorder;Funding;genetic risk factor;Genetic study;genetic variant;Glucose;glucosylceramidase;Glycolipids;Glycosphingolipids;glycosylation;Golgi Apparatus;Health;Hexosamines;Human;human induced pluripotent stem cells;Hydrolase;improved;In Vitro;in vivo;Inclusion Bodies;Induced Neurons;Induced pluripotent stem cell derived neurons;Knowledge;Lewy Bodies;Link;link protein;loss of function;loss of function mutation;Lysosomes;Membrane Fusion;Methods;misfolded protein;Modeling;mouse model;Mus;Mutation;Nerve Degeneration;Nervous System;Neurons;neurotoxicity;new therapeutic target;novel;novel therapeutic intervention;Parkinson Disease;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phenotype;Play;posters;prevent;Process;protein aggregation;Protein Biosynthesis;protein folding;protein transport;Proteins;proteostasis;proteostasis loss;Quality Control;response;Role;sensor;small molecule;SNAP receptor;Solubility;sound;Stress;Structure;synucleinopathy;System;Testing;therapy development;Toxic effect;trafficking;Transducers;Work

PROJECT_TITLE: The role of a-synuclein accumulation in lysosomal hydrolase trafficking and function


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative: A neurocomputational model of age-related differences in navigation Declines in spatial navigation often accompany advanced age and with a growing aging population, understanding the basis for age-related navigation differences is urgent. Therefore, developing experimental paradigms and models that can account for age- related differences in navigation is important to predicting who may be at risk for getting lost or having trouble finding their medicine, either as part of healthy or pathological aging. More generally, a deeper understanding of age-related declines in navigation is necessary to developing effective therapies that can help individuals with way-finding difficulties.

PI_NAMEs: EKSTROM, ARNE D (contact)

PROGRAM_OFFICER_NAME: THOMAS, CIBU PAUL

PROJECT_TERMS: Adult;Age;age difference;age effect;age related;age related changes;age related decline;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Atrophic;Back;Bayesian Modeling;Blood Screening;Brain imaging;Cognition;Cognitive;cognitive skill;Computer Models;Consensus;Coupled;Cross-Sectional Studies;Cues;Data;effective therapy;Elderly;entorhinal cortex;Environment;experience;experimental study;Goals;gray matter;head mounted display;healthy aging;Heterogeneity;high risk;Hippocampus;Human;Illusions;Impairment;Individual;Individual Differences;Learning;Leg;Location;Longitudinal Studies;Maps;Medicine;Metaphor;mild cognitive impairment;Modeling;multimodality;Nature;Neuropsychology;novel;older adult;Outcome;Participant;pathological aging;Patients;Pattern;preservation;Quality of life;Recording of previous events;response;Risk;Sampling;Sensory;skills;spatial memory;Testing;Time;Variant;virtual reality environment;Visual;Visual Illusions;Walking;way finding;young adult

PROJECT_TITLE: A neurocomputational model of age-related differences in navigation.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-N(02)M]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Congenital Structural Anomalies;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Social Determinants of Health

ORG_CITY: ALEXANDRIA

ORG_NAME: AMERICAN ASSOCIATION FOR DENTAL, ORAL, AND CRANIOFACIAL RESEARCH

ORG_STATE: VA

PHR: Project Narrative Enormous and unacceptable oral health disparities exist across vulnerable and underserved populations, cleft lip and palate remains a common birth defect, oropharyngeal cancer is rising in young adults –related to HPV, and we’ve yet to harness the true diagnostic value of salivary biomarkers or leverage the tremendous genomic medicine advances for oral health improvement. Dental caries remains one of the most common diseases of childhood, periodontal disease prevalence estimates have recently been revised upwards to nearly half the adult populations after a more thorough full-mouth exam methodology; and oral health consequences of the use of e-cigarettes remain largely unknown. The biologic impact of SARS- CoV2 on the craniofacial complex is a new critical area of exploration from potential sites of infection, transmission, and for reservoirs as well as the long-term impact on oral health from post-acute sequelae SARS-CoV-2 infection (PASC) or long-COVID and we must have a well- trained, diverse dental, oral, and craniofacial health research workforce to address these challenges, to serve as the catalyst to develop appropriate strategies and further the translation of dental, oral, and craniofacial research.

PI_NAMEs: FOX, CHRISTOPHER H (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: 2019-nCoV;Address;Adult;American Dental Association;Applications Grants;Area;Award;Biological;Biological Markers;California;career;career development;catalyst;Childhood;cleft lip and palate;clinical care;Collaborations;Congenital Abnormality;Continuing Education;craniofacial;craniofacial complex;Dental;Dental caries;Dental Students;diagnostic value;Disabled Persons;disadvantaged background;Disease;Disparity population;doctoral student;Educational workshop;electronic cigarette use;Elements;Eligibility Determination;Environment;Ethnic Origin;Ethnic Population;Evaluation;exhibitions;experience;Exposure to;Faculty;follow-up;Friends;Funding;Future;Gender Identity;Genomic medicine;Goals;Grant;Health;health disparity;Human Papillomavirus;improved;Infection;innovation;Institution;Investigation;Learning;lectures;Locales;Location;Long COVID;Louisiana;malignant oropharynx neoplasm;meetings;Mentors;Mentorship;Methodology;multidisciplinary;National Institute of Dental and Craniofacial Research;New York;Notification;Oral;Oral cavity;Oral health;outreach;Participant;Periodontal Diseases;Persons;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;Postdoctoral Fellow;Prevalence;Process;Program Evaluation;programs;Provider;Published Comment;Race;racial population;Religion;Reporting;Research;Research Personnel;Salivary;Schedule;Scientist;Secure;Sex Orientation;Site;Socioeconomic Status;student participation;Students;symposium;Technology;Time;Training;Translations;transmission process;Travel;Underrepresented Populations;Underserved Population;United States;United States National Institutes of Health;Vulnerable Populations;Woman;Writing;young adult

PROJECT_TITLE: AADOCR Bloc Travel Grant


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;HIV/AIDS;Infectious Diseases;Nutrition;Pediatric;Pregnancy;Prevention;Rare Diseases;Spina Bifida;Women's Health Research

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY HEALTH NETWORK

ORG_STATE: ON

ORG_ZIPCODE: M5G 2C4

PHR: PROJECT NARRATIVE Treatment with dolutegravir from conception has been associated with increased risk for neural tube defects, which has created uncertainty over the use of dolutegravir in the treatment of women of reproductive age living with HIV. Dolutegravir has also been associated with excess weight gain, a known risk factor for neural tube defects, suggesting that dolutegravir-associated metabolic alterations could contribute to the increased risk for neural tube defects. We will study the association of dolutegravir use in pregnancy with maternal and fetal metabolic alterations and the contribution to fetal defects, using murine in vivo and embryo culture models, and clinical samples from a pregnancy study in Botswana.

PI_NAMEs: SERGHIDES, LENA  (contact)

PROGRAM_OFFICER_NAME: MOYE, JACK

PROJECT_TERMS: Age;animal data;Animals;Anti-Retroviral Agents;antiretroviral therapy;biomarker selection;blood glucose regulation;Botswana;candidate validation;Carbon;Clinical;clinically relevant;clinically significant;Complement;Conceptions;Congenital Abnormality;congenital anomaly;Contracts;Data;Defect;Diabetes Mellitus;Dose;efavirenz;Embryo;embryo culture;Environment;excessive weight gain;experimental study;Exposure to;fetal;Fetus;First Pregnancy Trimester;Folic Acid;Folic Acid Deficiency;folic acid metabolism;General Population;Glucose;HIV;HIV Seronegativity;Human;In Vitro;in vivo;Incidence;Intervention;Investigation;Length;Link;Mediating;Metabolic;metabolic profile;Metabolism;metabolomics;Mitochondria;Modeling;Mothers;mouse model;Mus;National Institute of Child Health and Human Development;neural model;Neural Tube Defects;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Persons;Plasma;Pregnancy;pregnant;Pregnant Women;prepregnancy obesity;Prevention;prospective;protective effect;Recommendation;Regimen;Reporting;reproductive;Resistance;Resources;Risk;Risk Factors;Risk Reduction;Safety;Sampling;screening;surveillance data;System;Testing;Therapeutic;Toxic effect;Uncertainty;United States National Institutes of Health;Weight Gain;Woman;women's treatment;World Health Organization

PROJECT_TITLE: Defining the impact of dolutegravir on the maternal metabolic environment and its implications on risk of congenital anomalies.


ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Autoimmune diseases, which constitute a broad range of chronic illnesses, cause significant morbidity and mortality in the US and worldwide. Here we seek to understand how inhibitory pathways restrain enhanced TCR signaling strength to achieve peripheral tolerance and prevent autoimmunity. New mechanistic insights into peripheral tolerance regulation hold promise for improving or identifying new therapeutic strategies to treat spontaneous autoimmune diseases or to prevent autoimmunity resulting from cancer immunotherapy with checkpoint inhibitors.

PI_NAMEs: SHEN, LIN  (contact)

PROJECT_TERMS: Agonist;Alleles;anergy;anti-PD1 antibodies;Antigens;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;autoreactive T cell;autoreactivity;Biochemical;cancer immunotherapy;career;career development;Cells;Chronic Disease;Coupled;Cytoplasm;Cytoplasmic Protein;Data;Defect;Dependence;design;Development;Disease;Emigrations;Environment;Equilibrium;Exhibits;experimental study;Gene Expression Profile;Gene Expression Profiling;Goals;Heterogeneity;Human;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immune Tolerance;immunodeficiency;immunoregulation;improved;insight;Lipids;Lymphocyte;Mentors;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;novel therapeutic intervention;Pathogenesis;Pathway interactions;Peptides;Peripheral;peripheral tolerance;Phenotype;Physicians;Play;Preparation;prevent;programs;Protein Tyrosine Kinase;Protein Tyrosine Phosphatase;Proteins;Publishing;receptor;Regulation;Regulatory Pathway;Regulatory T-Lymphocyte;Research;Resources;response;restraint;Role;Scientist;Series;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Syndrome;synergism;T cell response;T-Lymphocyte;Techniques;Testing;Thymus Gland;Tissues;tool;Training;Training Programs;transcriptomic profiling;Transgenic Organisms;ubiquitin ligase;Up-Regulation

PROJECT_TITLE: Dissecting the interactions between TCR signaling strength and inhibitory pathways

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioids;Substance Misuse

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Opioid drug abuse is associated with worsening of neurocognitive deficits and other neurodegenerative effects seen with HIV infection. This grant proposes to use two in vivo models to examine the complex interplay of opiate-HIV-antiretroviral drug exposure on the central accumulation of drugs (antiretrovirals and morphine), blood-brain barrier function, and neuroimmune function in these mice. Gaining a better understanding of this dynamic interplay, with specific focus on antiretroviral brain concentrations, will improve the current therapeutic approaches for the opiate-using HIV population.

PI_NAMEs: MCRAE, MARY PEACE  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: ABCB1 gene;ABCG2 gene;Amantadine;Animal Model;Anti-Retroviral Agents;antiretroviral therapy;arm;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood damage;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;Brain region;Carrier Proteins;carvedilol;Cells;Cognitive;Cognitive deficits;Complex;cytokine;Dantrolene;Data;Drug Controls;drug efficacy;Drug Exposure;drug metabolism;Drug toxicity;Drug Transport;Event;Feedback;Glial Fibrillary Acidic Protein;Glucuronides;Goals;Grant;HIV;HIV anti-retroviral;HIV Infections;HIV-1;human model;Immune;immune cell infiltrate;Immunofluorescence Immunologic;Impaired cognition;Impairment;improved;in vivo;in vivo Model;Individual;Infection;Infiltration;Inflammation;Inflammatory;inhibitor;Knowledge;Macrophage;mass spectrometric imaging;Measures;Mediating;Metformin;migration;Modeling;monocyte;Morphine;motor deficit;mouse model;Mus;Nerve Degeneration;neuroAIDS;neurobehavioral;Neurocognitive;Neurocognitive Deficit;Neuroimmune;neuroinflammation;neuropathology;neurotoxic;Opioid;opioid abuse;opioid exposure;opioid use;Outcome;Pathogenesis;patients who use opioids;Penetration;Permeability;Pharmaceutical Preparations;Population;Production;promoter;protein expression;Quinidine;recruit;regional difference;Reporting;RNA Interference;Role;Signal Transduction;targeted treatment;tat Protein;Therapeutic;therapeutic development;Time;trafficking;Transgenic Mice;Transgenic Organisms;Treatment Efficacy;Viral Proteins;Western Blotting;Work

PROJECT_TITLE: Opioid- and HIV-mediated effects on the integrity of the blood-brain barrier, on immune cell recruitment, and on antiretroviral penetration into thebrain

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cerebrovascular;Gene Therapy;Genetics;Nanotechnology;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Regenerative Medicine;Rehabilitation

ORG_CITY: STANFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative: The thesis and F99 phase of this proposal investigates a nanomedicine-based approach to drive the peripheral nerve regeneration and functional recovery, while also working to limit neuromuscular degeneration resulting from the loss of nerve function by creating new neurons within the muscle to promote and preserve healthier state. The applications of genetic and cell-based therapies extend well beyond the study of nerve regeneration and will be applied to neurodevelopmental disorders in the K00 period. Completion of the F99 phase will provide professional, intellectual, and technical training in preparation for the transition to the postdoctoral phase (K00) of the award.

PI_NAMEs: MOORE, JORDAN TAYLOR (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: age related;Alzheimer's Disease;angiogenesis;Architecture;Atrophic;Award;Axon;axon regeneration;Biomedical Engineering;Bioreactors;Blood - brain barrier anatomy;Blood Vessels;Brain-Derived Neurotrophic Factor;Cell Reprogramming;Cell Therapy;Cells;Central Nervous System;Cerebral Palsy;Chromosome Mapping;community involvement;Cues;Data;Development;developmental neurobiology;doctoral student;Drug Delivery Systems;Effectiveness;Electroporation;Engineering;Environment;Experimental Designs;Foundations;Functional disorder;functional restoration;Gene Delivery;gene therapy;Genes;Genetic;Goals;Growth;healing;Health;Histologic;Immune response;improved;Injectable;injured;Injury;innovation;Intervention;Ischemic Stroke;Knowledge;Lead;Leadership;Left;loss of function;Manuscripts;Mediating;Mentors;Mentorship;meter;Methods;Modeling;Molecular;Motivation;motor function improvement;Motor Neurons;Mus;Muscle;Muscle Cells;nanochannel;nanomedicine;nanotransfection;Natural regeneration;Nerve;Nerve Degeneration;nerve injury;Nerve Regeneration;nerve repair;Nervous System Physiology;neural;Neurites;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;neuromuscular;neuromuscular function;Neuromuscular Junction;neuronal cell body;Neurons;neurovascular;non-viral gene delivery;Ohio;Organ;Outcome;Peripheral nerve injury;peripheral nerve regeneration;Peripheral Nerves;Phase;plasmid DNA;Population;Positioning Attribute;Postdoctoral Fellow;posters;pre-doctoral;precision medicine;Predisposition;Preparation;preservation;programs;Quality of life;Recovery of Function;regeneration function;reinnervation;repaired;Research;Research Personnel;Research Project Grants;response;Role;scaffold;sciatic nerve injury;Science;Site;Skeletal Muscle;skills;Spinal Ganglia;STEM field;Stroke;System;Technical Expertise;tenure track;Testing;Therapeutic;Tissues;Training;Universities;vascular injury;Vascular System;Vertebral column;Viral Vector;Work;Writing;Youth

PROJECT_TITLE: Injectable drug-delivery system to repair the blood-brain-barrier after ischemic stroke


NIH_SPENDING_CATS: Aging;Back Pain;Genetics;Pain Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it investigates how a class of cell type known as cellular senescence drives age-dependent intervertebral disc degeneration that results in low back pain. The proposed studies aim to elucidate the molecular and cellular mechanisms through which cellular senescence promotes disc aging and identify therapeutic drug interventions to mitigate age-dependent intervertebral disc degeneration at the systemic and local disc tissue level.

PI_NAMEs: VO, NAM V (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Age Months;age related;aged;Aging;Automobile Driving;Back Pain;Behavior;Biology;Blood;CDKN1A gene;CDKN2A gene;cell age;Cell Aging;Cell Culture Techniques;Cell Cycle Proteins;Cell Therapy;cell type;Cells;Chronic;chronic back pain;Clinical;Dasatinib;Data;disability;disc regeneration;Disease;DNA Damage;DNA Repair Endonuclease;DNA Repair Gene;Economic Burden;Economics;Endocrine;ERCC1 gene;Event;experimental study;Exposure to;fisetin;Funding;Genetic;health economics;Human;human model;Immune system;Immunological Models;Inflammatory;innovation;Intervention;Intervertebral disc structure;intervertebral disk degeneration;Knock-out;Knowledge;Laboratories;Low Back Pain;LOX gene;Maps;Mediating;Modeling;Molecular;mouse model;Mouse Strains;Mus;Mutagens;normal aging;novel;old mice;Parabiosis;Pathway interactions;Pharmaceutical Preparations;Phenotype;Process;promoter;Public Health;Quercetin;Regenerative research;Reporter;Research;Risk Factors;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Signal Transduction;socioeconomics;Spinal Diseases;success;Syndrome;Testing;Therapeutic;Therapeutic Effect;Tissues;Transgenic Mice;Transgenic Organisms;Vertebral column

PROJECT_TITLE: Mechanisms of Cellular Senescence Driving Intervertebral Disc Aging through Local Cell Autonomous and Systemic Non-Cell Autonomous Processes


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Genetics;Human Genome;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Narrative There is a growing body of research confirming the role of epigenetic events promoting or repressing the expression of genes that shape the risk of an individual to become affected by multiple sclerosis. The principal goal of the proposed project is to identify these landmarks at the single cell level in blood and cerebrospinal fluid.

PI_NAMEs: OKSENBERG, JORGE R. (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: 3-Dimensional;6p21;Affect;African American;Age;Antibody Therapy;Atlases;Automobile Driving;B-Lymphocytes;biobank;Biological Markers;Blood;California;case control;CD19 gene;Cell Communication;Cell Physiology;Cell surface;Cells;Cellular Assay;Cerebrospinal Fluid;Chromatin;Chromosomes;Clinical;cohort;Coupled;Data;Data Set;Development;Diagnosis;disability;Disease;disease model;Disease susceptibility;disorder risk;diverse data;DNA;DNA Methylation;Epigenetic Process;epigenomics;Event;follow-up;Gene Expression;Gene Expression Profile;Genetic;genome wide association study;Genotype;Goals;Heterogeneity;histone modification;Immune;Immunologics;Individual;insight;Ligands;Link;Magnetic Resonance Imaging;Major Histocompatibility Complex;Maps;Measurement;Measures;Modality;Modeling;Modification;multiple omics;Multiple Sclerosis;multiple sclerosis patient;novel;Participant;Pathogenesis;Pathologic;Patient Recruitments;Peripheral;Peripheral Blood Mononuclear Cell;Phenotype;phenotypic data;polygenic risk score;Population;Process;Prognosis;prognostic;programs;Quantitative Trait Loci;receptor;Repression;Research;Resolution;Risk;Role;Sampling;sex;Shapes;single cell ATAC-seq;single-cell RNA sequencing;statistics;Susceptibility Gene;Symptoms;System;Therapeutic;Time;tositumomab;transcriptome;Update;Validation;Visualization

PROJECT_TITLE: DNA methylation in the development of multiple sclerosis

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE: Training the next generation of academicians in gastroenterological sciences continues to be the primary goal of the UCLA NIH T32 GI training program which has a long, productive history over the last 48 years. Through state-of-the art, multidisciplinary scientific approaches provided by a diverse faculty of 34 dedicated, experienced, and successful mentors and a highly supportive administrative platform, we strive to continue our recruitment, research mentoring, and nurturing of outstanding trainees including women and under-represented minorities from adult and pediatric GI fellowships, the UCLA STAR program, the UCLA General Surgery residency, and other UCLA post-doctoral programs. The breadth of training is from basic science and translational research to clinical and health services research with an emphasis on didactic training through UCLA graduate school programs and with major institutional resources to sustain the excellence and productivity of this important training program.

PI_NAMEs: JENSEN, DENNIS MICHAEL (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Gastroenterology

PROJECT_TITLE: Gastroenterology


NIH_SPENDING_CATS: Diabetes;Nutrition

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Pancreatic beta and alpha cells couple nutrients with insulin and glucagon secretion and abnormalities in nutrient signaling can lead to defects in insulin and glucagon secretion in the pathogenesis of diabetes. The signaling mechanism that regulates the tight link nutrient sensing and the insulin and glucagon secretion characteristics of beta and alpha cells are not completely understood. In this study, we aim to characterize how amino acid sensing mechanisms regulate the function and mass of beta and alpha cells during normal conditions and diabetes development.

PI_NAMEs: BERNAL-MIZRACHI, ERNESTO  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Acute;Alpha Cell;Amino Acids;antagonist;Arginine;Aromatic Amino Acids;B-Lymphocytes;Beta Cell;blood glucose regulation;Branched-Chain Amino Acids;Cell Physiology;Cells;Characteristics;Chronic;Circulation;cohort;Complex;Coupling;Cytoplasm;Data;Defect;detection of nutrient;Development;Diabetes Mellitus;diabetes pathogenesis;diabetes risk;diabetic;dietary;Disease;drug development;Exhibits;Fasting;Functional disorder;genetic approach;Glucagon;Glucagon Receptor;Glucose;Glucose Intolerance;Goals;Guanosine Triphosphate Phosphohydrolases;Homeostasis;Human;human data;Hyperglycemia;Impairment;In Vitro;in vivo;insight;Insulin;Insulin Resistance;insulin secretion;islet;Learning;Leucine;Link;Mediating;Metabolic;Molecular;Monitor;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Nutritional;Obesity;Pathogenesis;Pathologic;Pathway interactions;Physiological;Physiology;Play;Publishing;Reporting;Resistance;response;Risk;Role;sensor;Signal Pathway;Signal Transduction;Structure of beta Cell of islet;Testing;Tissues;Work

PROJECT_TITLE: Amino acid sensing mechanisms in beta and alpha cells

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE This project will identify molecular mechanisms regulating the development and maturation of astrocytes, one of two classes of non-neuronal cells in the brain that play essential roles in health and disease. Despite recognition of the critical and diverse roles astrocytes play in brain function, the mechanisms and principles governing their identity and function remain poorly understood. Gaining insight into the molecular signaling programs regulating astrocyte identity and function will facilitate the development of novel therapies targeting these cells for restoration or repair in the injured or diseased brain.

PI_NAMEs: GARCIA, ANNA DENISE RESURRECCION (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: 3-Dimensional;Ablation;Address;astrocyte progenitor;Astrocytes;Bioinformatics;Biology;Blood - brain barrier anatomy;Brain;Brain Diseases;Cell Lineage;cell type;Cells;cellular transduction;Characteristics;Compensation;Complement;Data;Development;Disease;experimental study;Gene Expression;Genetic Transcription;Goals;Health;high resolution imaging;injured;insight;Ions;loss of function;Maps;Mediating;Molecular;Molecular Genetics;molecular phenotype;Morphogenesis;Morphology;neural circuit;neural repair;Neuroglia;neuromechanism;Neurons;Neurotransmitters;new therapeutic target;novel;Oligodendroglia;Perinatal;Phenotype;Play;Population;postnatal;postnatal development;Production;progenitor;programs;Property;Prosencephalon;reconstruction;Regulation;repaired;restoration;Role;SHH gene;Signal Pathway;Signal Transduction;smoothened signaling pathway;stem cells;Synapses;synaptogenesis;tool;transcriptome sequencing

PROJECT_TITLE: Elucidating the Role of Sonic Hedgehog Signaling in Cells Along the Astrocyte Lineage

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: BALTIMORE

PHR: Project Title: Ion Channel Function and Regulation of the Polycystin-1/2 complex in Kidney Physiology and Polycystic Kidney Disease Project Narrative: Despite the clear linkage between polycystin-1/polycystin-2 (polycystin-1/2) ion channel protein complex and polycystic kidney disease (PKD), the function and regulation of this complex and the role of its ion channel activity in kidney cyst formation is largely unknown. This multi-PI project will provide critical insights into the fundamental molecular mechanism of the polycystin-1/2 channel function and regulation, and discover its requirement in ensuring normal kidney development and preventing cyst formation. It is expected that the proposed studies will lead to a better understanding of PKD pathogenesis and help form the basis for targeting the polycystin-1/2 channel for preventive and therapeutic purposes.

PI_NAMEs: QIAN, FENG  (contact);YU, YONG

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Affect;Amino Acids;Architecture;Autosomal Dominant Polycystic Kidney;Binding;Biochemical;Biological Assay;Biological Process;C-terminal;Calcium;Cations;Coiled-Coil Domain;Complex;Coupling;Cryoelectron Microscopy;Cyst;Cystic kidney;Development;Disease;EF Hand Motifs;Electrophysiology (science);Ensure;extracellular;G-Protein-Coupled Receptors;gain of function;Goals;Human;in vivo;insight;Ion Channel;Ion Channel Protein;Ions;Kidney;Kidney Diseases;Knock-in Mouse;Laboratories;Life;Link;Liquid substance;Live Birth;loss of function;Maps;Measures;Mediating;Membrane;Methods;Molecular;Morphogenesis;Morphology;mouse model;mutant;Mutant Strains Mice;Mutate;Mutation;N-terminal;nephrogenesis;Nephrons;new therapeutic target;novel;Pathogenesis;Pathogenicity;Pathway interactions;Permeability;Physiology;PKD1 gene;PKD2 gene;PKD2 protein;Play;polycystic kidney disease 1 protein;Polycystic Kidney Diseases;Potassium;preservation;prevent;Preventive;Process;Property;Proprotein Convertase 1;Proprotein Convertase 2;protein complex;Proteins;Proteolysis;Publishing;receptor;Regulation;Renal function;Role;Signal Pathway;Signal Transduction;Site;Sodium;stoichiometry;Structure;success;System;Tail;targeted treatment;Testing;Therapeutic;therapeutic target;therapy development;TRP channel;Uncertainty;Xenopus oocyte

PROJECT_TITLE: Ion Channel Function and Regulation of the Polycystin-1/2 Complex in Kidney Physiology and Polycystic Kidney Disease

STUDY_SECTION: KMBD

STUDY_SECTION_NAME: Kidney Molecular Biology and Genitourinary Organ Development[KMBD]