NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: TDP-43 pathology has been seen in a number of neurodegenerative diseases, but the mechanism by which TDP-43 contributes to cellular toxicity is still not fully understood. Our recent results from a large ALS and FTD patient profiling consortium have shown that TDP-43 normally regulates expression of retrotransposons and that elevation of retrotransposons accompanies TDP-43 pathology in human cortex. Retrotransposons have been shown to be both neuroinflammatory and neurotoxic in other disease contexts, and thus their ability to contribute to TDP-43 pathomechanisms will form the focus on this proposal.

PI_NAMEs: GALE HAMMELL, MOLLY  (contact);PHATNANI, HEMALI

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;ALS patients;Alzheimer's Disease;Alzheimer's disease patient;Astrocytes;Atlases;Autopsy;Cell model;cell type;Cells;Coculture Techniques;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Dementia;Disease;experimental study;frontal lobe;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Gene Expression Profile;Genomics;glial activation;Grant;histological stains;Human;Image;Immune signaling;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammatory;inflammatory marker;innate immune pathways;Link;Mediating;Microglia;Molecular;Molecular Profiling;Motor Cortex;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neuronal Differentiation;Neurons;neurotoxic;neurotoxicity;Organoids;Oxidative Stress;Pathologic;Pathology;Pathway interactions;Patient Selection;Patients;protein aggregation;protein TDP-43;Proteins;pseudotoxoplasmosis syndrome;Reporting;Resolution;Retrotransposon;Sampling;Signal Pathway;Slice;Sudden Death;System;TDP-43 aggregation;Testing;Tissue Banks;Tissue Sample;Tissue Stains;Tissues;Toxic effect;transcriptome;transcriptomics;TREM2 gene;Work

PROJECT_TITLE: Connecting TDP-43 Pathology to the Molecular Profiles of Neurodegeneration


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: The suicide rate among female Veterans is a growing concern, yet very little research has sought to understand how to alleviate risk among this group. As such, we know surprisingly little about the health and psychosocial experiences, healthcare utilization, or barriers to care for female Veterans at risk for suicide. By interviewing Veterans about their lived experiences with suicidal thoughts, suicide attempts, and recovery needs, we will begin to develop an understanding of female Veterans' risk. Then, we will follow a large cohort of female and male Veterans over time to develop and test an explanatory model of female Veterans' risk. Findings from this study will reveal which health and psychosocial experiences are predictive of suicide attempts among female Veterans as well as which healthcare services and barriers to care require attention, providing much-needed evidence to guide the selection of intervention targets and direct valuable suicide prevention resources.

PI_NAMEs: DENNESON, LAUREN M (contact)

PROJECT_TERMS: Address;administrative database;Attention;barrier to care;Biological;Caring;cohort;coping;Coping Skills;cost;Cross-Sectional Studies;Data;data warehouse;Development;Diagnosis;Distal;Distress;Enrollment;Event;evidence base;experience;falls;Feeling;Feeling suicidal;Female;follow-up;Gender;gender difference;Gender Role;Goals;Health;health care service;health care service utilization;Healthcare;Healthcare Systems;high risk;high risk population;High Risk Woman;interpersonal conflict;Intervention;Interview;Lived experience;Longitudinal cohort study;Longitudinal Studies;Longitudinal Surveys;male;Measures;Mediating;Medical Records;Mental Depression;Mental Health;Methodology;Methods;Military Personnel;military veteran;Modeling;Occupational;Participant;Patient Self-Report;Pattern;Population;Prevention approach;primary outcome;Process;psychosocial;Psychosocial Factor;Public Health;Questionnaires;Recording of previous events;Recovery;Reporting;Research;Research Priority;Resources;response;Risk;Risk Factors;Sample Size;Sampling;Self Direction;Services;sexual trauma;social;Socialization;Source;Stress;stressor;Substance Use Disorder;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surveys;Symptoms;Testing;Theoretical model;theories;Time;Transcript;Trauma;Veterans;Violence;women versus men;Women's cohort;women's prevention;Women's study;Work

PROJECT_TITLE: Advancing Suicide Prevention for Female Veterans

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE Medulloblastoma is the most common malignant brain tumor in children; although aggressive treatments have improved outcomes, many patients still die of their disease, and survivors suffer severe long-term side effects from the therapy. Our previous studies have identified pathways that are critical for growth of medulloblastoma, and uncovered agents that may be effective for therapy of the disease. Our overarching goal in the coming years is to develop a deeper understanding of the molecular basis of medulloblastoma and to use this information to discover safer and more effective approaches for treating the disease.

PI_NAMEs: WECHSLER-REYA, ROBERT J. (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: aggressive therapy;Animal Model;Biology;Cells;Child;Childhood Brain Neoplasm;Critical Pathways;Disease;effective therapy;Goals;Growth;Immune response;improved outcome;Maintenance;Malignant neoplasm of brain;Medulloblastoma;Metastatic Neoplasm to the Leptomeninges;Modeling;Molecular;novel strategies;novel therapeutics;Patients;Pediatric Neoplasm;Research;side effect;Survivors;tumor;tumor initiation

PROJECT_TITLE: Identifying and Targeting the Drivers of Pediatric Brain Tumors


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Opioid use disorder is on the rise and the economic and human cost is staggering, so understanding the factors that promote resilience to opioid misuse is critical. The preclinical, neurobiological studies in this proposal will reveal how manipulations early in life promote resilience to the development of addiction-related phenotypes from the behavioral to the molecular level. These findings can help guide the development of novel interventions to better treat opioid use disorder.

PI_NAMEs: BANGASSER, DEBRA A (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Adult;Adverse event;Affect;Animal Model;Beds;Behavior;behavior test;Behavioral;behavioral phenotyping;Brain;chromatin remodeling;cost;Data;Dependence;design;Development;discounting;Disease;Dose;early experience;early life adversity;early life stress;Economics;Environment;Enzymes;Epigenetic Process;Ethics;Event;experience;Exposure to;Female;Gene Expression;Genes;Genetic Transcription;glutamatergic signaling;Glutamates;HDAC1 gene;Histone Acetylation;Histone Deacetylase;Histone Deacetylase Inhibitor;histone modification;Histones;Human;hypothalamic-pituitary-adrenal axis;Impulsivity;innovation;Intake;Intervention;Life;Life Experience;Link;male;Measures;Mediating;Mental disorders;Metabolic;Modeling;Modification;Molecular;Morphine;Neurobiology;Neurons;neurotransmission;novel;Nucleus Accumbens;Opioid;opioid misuse;opioid use;opioid use disorder;overexpression;Paper;Persons;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Positioning Attribute;postnatal;postsynaptic;Poverty;pre-clinical;pre-clinical research;presynaptic;Probability;programs;promote resilience;Psychological reinforcement;pup;Rattus;Regulator Genes;Research Personnel;resilience;Resource-limited setting;Resources;response;reward circuitry;Rewards;Risk;Risk Factors;Self Administration;sex;Sex Differences;Specificity;Stress;Substance Use Disorder;Tail;Testing;tool;transcriptome;transcriptome sequencing;transmission process;Viral;Whole-Cell Recordings;Work

PROJECT_TITLE: Sex differences in stress inoculation of addiction-like phenotypes

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Hematology;Immunotherapy;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Graft-versus-host disease (GVHD) remains a significant problem in the use of allogeneic hematopoietic stem cell transplantation to cure a broad range of hematologic malignancies, bone marrow failure states, and genetic disorders; thus, novel approaches to prevent GVHD are critically needed. The adoptive transfer of certain subsets of murine invariant natural killer T (iNKT) cells have been shown to suppress GVHD, and human studies suggest a similar role for iNKT cells, but the heterogeneity of human iNKT cells remains largely unexplored and the subset best suited to prevent GVHD is unknown. The proposed research will define human iNKT cell heterogeneity and develop strategies for targeted selection and generation of immunosuppressive iNKT cells, yielding important preclinical data that will inform the design of a future clinical trial of iNKT adoptive transfer for prevention of GVHD and providing a framework for future studies of iNKT cells in other diseases.

PI_NAMEs: MAVERS, MELISSA  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute Graft Versus Host Disease;Adoptive Transfer;Advisory Committees;Allogenic;antimicrobial;Autoimmunity;Bone marrow failure;Cancer Relapse;career;career development;cell injury;Cell Physiology;Cells;Cellular Immunology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;cellular transduction;Clinical Trials;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;Data;design;Development Plans;Disease;disorder prevention;Engineered Gene;engineered T cells;Ensure;experience;experimental study;Future;Generations;Genetic Diseases;Genetic Engineering;Goals;graft vs host disease;graft vs leukemia effect;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Heterogeneity;high risk;High-Risk Cancer;Human;Human Characteristics;immune reconstitution;Immunophenotyping;immunoregulation;immunosuppressed;Immunosuppression;In Vitro;in vitro Assay;in vivo;Infection;insight;Interleukin-10;Interleukin-4;Lentivirus Vector;leukemia;Malignant Neoplasms;Mediating;Mentors;Mixed Lymphocyte Culture Test;Molecular;Morbidity - disease rate;mortality;Mus;Natural Killer Cells;Non-Malignant;novel;novel strategies;overexpression;Patients;Pattern;Phenotype;Physicians;Play;Population;pre-clinical;prevent;Prevention;Prevention strategy;Production;programs;Proteins;Proteomics;Reaction;Regulatory T-Lymphocyte;Research;Role;Scientist;skills;Sorting;Surface;T cell therapy;T-Cell Depletion;T-Lymphocyte;Techniques;Therapeutic Uses;Tissues;Toxic effect;Training;transcriptome sequencing;transcriptomics;Work;Xenograft procedure

PROJECT_TITLE: Immunosuppressive human invariant natural killer T cells for prevention of graft-versus-host disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project proposes to deconstruct the mechanism underlying response to antipsychotic treatment in patients with early schizophrenia. The information gathered from this work is of considerable public health significance given its potential to 1) establish promising avenues for the development of novel treatments for psychotic symptoms; 2) optimize our existing treatments; 3) uncover the molecular and neural mechanisms that contribute to psychosis. Knowledge gained from this project may ultimately reduce the public health burden experienced by people living with this disabling psychiatric condition.

PI_NAMEs: SARPAL, DEEPAK K (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Acute;Address;Aftercare;Antipsychotic Agents;Basal Ganglia;Biological Assay;biomarker development;Cells;Characteristics;Classification;Clinical assessments;Clinical Trials;cohort;Communities;computational neuroscience;Computing Methodologies;Corpus striatum structure;Data;Development;Dimensions;Disabling;Disease;Dissection;Dopamine;Dopamine D2 Receptor;dopamine system;Economic Burden;Exhibits;experience;Family member;Foundations;Functional disorder;gamma-Aminobutyric Acid;Ganglia;glutamatergic signaling;Glutamates;Healthcare Systems;Heterogeneity;Hippocampus;Image;imaging study;in vivo;Individual;information gathering;innovation;Knowledge;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Measures;Mediating;Metabolism;Methodology;Methods;Midbrain structure;Molecular;Morbidity - disease rate;multimodality;National Institute of Mental Health;neurobiological mechanism;Neurobiology;neuroimaging;neuromechanism;neuromelanin;Neurons;neurotransmission;Neurotransmitters;next generation;Normal Range;novel;novel therapeutics;Patients;personalized therapeutic;Persons;Pharmaceutical Preparations;Positioning Attribute;Positron-Emission Tomography;Prefrontal Cortex;presynaptic;prospective;Prospective Studies;Proxy;Psychoses;psychotic;psychotic symptoms;Public Health;Publishing;Radiation exposure;Refractory;Research;Resolution;responders and non-responders;response;Scanning;Schizophrenia;schizophrenia spectrum disorder;Secondary to;Societies;spectroscopic imaging;success;System;Testing;Thalamic structure;therapeutic development;transmission process;treatment effect;Treatment Efficacy;Treatment Failure;treatment responders;treatment response;Work

PROJECT_TITLE: A Multidimensional Dissection of Antipsychotic Treatment Response in Early Schizophrenia

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: The impacts of Alzheimer disease on patients, families, caregivers and society are shattering. Regrettably, there are no drugs that can cure Alzheimer disease. We have created new rat models of Alzheimer disease: this model will be to identify therapeutic targets and test drugs that will prevent and/or cure Alzheimer disease.

PI_NAMEs: D'ADAMIO, LUCIANO  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Abeta clearance;Adult;Age-associated memory impairment;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease model;Amino Acids;Amyloid Beta A4 Precursor Protein;Amyloid beta-Protein;amyloid precursor protein processing;Animal Model;Animals;autosomal dominant mutation;Behavioral;beta secretase;Binding;Brain;Brain Pathology;Caregivers;Cells;Cerebrum;Cognitive;Consensus;Dementia;Deposition;Disease;disease-causing mutation;drug testing;early onset;Elderly;Equilibrium;extend lifespan;familial Alzheimer disease;Family;gamma secretase;Gene Mutation;Genetic;genetic variant;Human;hyperphosphorylated tau;Impaired cognition;Impairment;Individual;insight;Knock-in;Learning;Link;Mediating;Memory;Microglia;Microtubules;model organism;Modeling;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;Neurons;Organism;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathologic Processes;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Physiological Processes;Population;presenilin-1;presenilin-2;Prevalence;prevent;protective allele;Protein Isoforms;Proteolytic Processing;Rattus;Research;Risk;Rodent;Role;Senile Plaques;Signal Transduction;Societies;Spices;Synaptic Transmission;tau expression;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutic evaluation;therapeutic target;therapeutically effective;TNF gene;transcriptome;transcriptomics;Transgenic Model;Transgenic Organisms;Treatment Efficacy;TREM2 gene;Variant

PROJECT_TITLE: Trem2-mediated microglia-neuronal axis in Alzheimer disease pathogenesis


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Machine Learning and Artificial Intelligence;Nanotechnology;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: STONY BROOK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: NARRATIVE A quantitative laparoscopic spatial frequency domain imaging platform is proposed to map intraperitoneal ovarian metastases as well as to treat them effectively via targeted chemo-photo therapy. Cancer-targeting drug and optimized light delivery will allow local release and preferential uptake of the drug into tumors versus normal tissue for optimal cancer cell destruction with minimal side effects to the surrounding normal tissue. This approach is relevant to public health as it is expected to significantly improve detection and destruction of micromets in ovarian cancer patients, and reduce side effects in normal tissue, thereby fulfilling the overarching goal of improving patients’ survival rates and quality of life.

PI_NAMEs: SUNAR, ULAS  (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: absorption;Acids;Address;Adjuvant Chemotherapy;Algorithms;anti-cancer;Antineoplastic Agents;attenuation;Biodistribution;Biopsy;cancer cell;cancer diagnosis;Cancer Patient;cancer therapy;Cell Culture Techniques;Cell Line;chemotherapy;Clinic;Clinical;Combination Drug Therapy;contrast enhanced;controlled release;Data;deep learning;deep learning algorithm;Detection;Diagnosis;Disease;Dose;Doxorubicin;Drug Targeting;Ensure;Epithelial ovarian cancer;Epithelium;Excision;Exposure to;Feedback;Fluorescence;fluorescence imaging;Folic Acid;FOLR1 gene;Goals;Image;image guided;image guided therapy;image-guided drug delivery;imaging approach;imaging detection;imaging modality;imaging platform;Imaging technology;improved;In Vitro;in vivo;intraperitoneal;Kinetics;Laparoscopes;Lead;Lesion;Light;Lighting;Lipids;liposome vector;Liposomes;malignant mouth neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Metastatic Malignant Neoplasm to the Ovary;Micrometastasis;Microscopic;Modality;Monitor;nano;nanocarrier;nanomedicine;Neoplasm Metastasis;Nodule;Normal tissue morphology;novel;Operative Surgical Procedures;optical imaging;Ovarian;Ovarian Carcinoma;Patients;phantom model;Pharmaceutical Preparations;Phospholipids;Photosensitizing Agents;Phototherapy;Physiological;Platinum;Porphyrins;Protocols documentation;Public Health;PUVA Photochemotherapy;Quality of life;quantitative imaging;Recurrence;Resistance;Resolution;Scheme;Sensitivity and Specificity;Shapes;side effect;Signal Transduction;Spatial Frequency Domain Imaging;spatiotemporal;Specificity;Structure;Surface;Survival Rate;System;targeted treatment;Technology;Therapeutic;Time;Tissues;Toxic effect;Translating;Treatment Efficacy;treatment optimization;Treatment-related toxicity;tumor;tumor specificity;uptake;Visualization

PROJECT_TITLE: Quantitative Fluorescence Imaging-Guided Detection and Targeted Therapy Monitoring Platform for Ovarian Cancer Micrometastases


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebral Palsy;Cerebrovascular;Childhood Injury;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Infant Mortality;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Stroke;Unintentional Childhood Injury;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: MAESTRA Project Narrative Hypoxic-ischemic encephalopathy (HIE) occurs when a baby gets reduced oxygen and blood flow to the brain, and can lead to death or long-term disabilities such as cerebral palsy. During labor and delivery, doctors are able to continuously record the heart rate of the fetus. This study will determine how best to use the heart rate information so that we can reduce the number of infants who develop this severe brain condition.

PI_NAMEs: KEARNEY, ROBERT EDWARD;WU, YVONNE W (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Acidosis;Address;Apgar Score;Asphyxia;Blood;Blood flow;Brain;California;Categories;Cause of Death;Cerebral Palsy;Cesarean section;Cessation of life;Characteristics;Classification;Clinical;Clinical Data;Clinical Trials;cohort;Cohort Studies;computerized;Computerized Medical Record;Data;Data Set;design;digital;digital data;Discipline of obstetrics;Educational workshop;effectiveness evaluation;Electronics;falls;fetal;Fetal Heart Rate;Fetal Monitoring;Fetus;fetus at risk;Frequencies;Future;Heart Rate;high risk;improved;Infant;large datasets;Lead;Link;Long term disability;Machine Learning;Manuals;Metabolic acidosis;Metabolic Brain Diseases;Methods;Modeling;Modernization;Mothers;multidisciplinary;National Institute of Child Health and Human Development;Neonatal;Neonatal Brain Injury;neonatal hypoxic-ischemic brain injury;neonatal seizure;Neurologic;Neurological disability;Newborn Infant;novel;Observational Study;Outcome;Oxygen;Pattern;Perinatal;Perinatal mortality demographics;Population;population based;Positioning Attribute;predictive modeling;Predictive Value;Pregnancy;prenatal;prevent;preventive intervention;Records;Reporting;Research;Research Priority;Retrospective cohort study;Risk;routine care;Sensitivity and Specificity;signal processing;Signal Transduction;standard measure;standard of care;Syndrome;System;Techniques;Term Birth;Testing;Time;uterine contractility;Uterine Contraction;Uterus;Validation

PROJECT_TITLE: Maternal Antecedents and Electronic Fetal Monitoring in Term Asphyxia (MAESTRA)

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Lung cancer is the leading cause of cancer deaths, and African Americans have the highest lung cancer incidence and mortality rates when compared with any other racial or ethnic group in the U.S. We will study the biological differences between lung tumors from African Americans and European Americans. Our goal is to develop treatments that consider biomarkers and therapeutic responses based on biological differences that will help to reduce lung cancer racial health disparities.

PI_NAMEs: PINE, SHARON R. (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: addiction;Address;African American;African American population;American;angiogenesis;Antisense Oligonucleotides;Antitumor Response;Apoptotic;Automobile Driving;base;Behavior;Biological;Biological Factors;Biological Markers;Cancer Biology;Cancer Etiology;cancer health disparity;Cancer Model;Cancer Patient;cancer risk;cancer survival;Carboplatin;Cell Proliferation;Cells;Cessation of life;Chemoresistance;chemotherapy;Classification;Clinical;Clinical Research;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Data;data integration;Death Rate;Development;Disparity;Ethnic Population;European;Future;Gene Expression;genome editing;Genomics;Goals;health disparity;high throughput screening;Histologic;IL6 gene;improved;in vivo;Incidence;inhibitor;Institution;Invaded;Lung Adenocarcinoma;Lung Neoplasms;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;men;migration;Modeling;Molecular;Molecular Profiling;molecular subtypes;multidisciplinary;Mus;mutant;Mutation;Non-Small-Cell Lung Carcinoma;novel;novel marker;Oncogenic;Organoids;Outcome;Paclitaxel;Pathway interactions;patient derived xenograft model;Patient Selection;patient subsets;Patients;Pattern;Phosphoric Monoester Hydrolases;Population;pre-clinical;predictive marker;PTPRT gene;Race;racial difference;racial health disparity;racial population;recruit;Research;response;response biomarker;Signal Induction;Signal Transduction;small molecule inhibitor;Smoking;social health determinants;Socioeconomic Factors;Stat3 protein;STAT6 Transcription Factor;Testing;Therapeutic Intervention;therapeutic target;therapeutically effective;therapy resistant;transcription factor;transcriptomics;Treatment Efficacy;treatment response;tumor;Tumor Biology;tumor growth;tumor progression;tumorigenic;Xenograft procedure

PROJECT_TITLE: Discovery and therapeutic targeting of biological determinants of lung cancer health disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Z(55)R]


ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The proposed study is to conduct a large scale genomic discovery of recurrent pregnancy loss using an integrated and innovative genomics approach and construct an intolerome to guide the evaluation of pregnancy loss in clinic and studies of the human early development.

PI_NAMEs: HALL, IRA M;JIANG, YONG-HUI  (contact);REDDY, UMA ;TAYLOR, HUGH SMITH

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: biobank;Bioinformatics;bioinformatics tool;Biometry;Cell Line;Chromosome Mapping;Chromosomes;Clinic;Clinical;clinical phenotype;Clinical Research;clinical research site;Code;cohort;Collaborations;Collection;computerized data processing;Conceptions;Counseling;Couples;Data;Data Analyses;Data Science;Data Set;Data Sources;design;Detection;Development;Diagnosis;Disease;Etiology;Evaluation;Exclusion;exome sequencing;experience;Fathers;Fetal Development;Funding;Future;gene discovery;Generations;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;Genetic study;genetic variant;Genome;genome sequencing;genome-wide;Genomic approach;genomic predictors;genomic variation;Genomics;Goals;grandparent;Heterozygote;Human;Human Development;Human Genetics;human pangenome;improved;innovation;Knock-out;Lead;Leadership;Machine Learning;Maps;Mendelian disorder;Methods;Minority;Mitochondria;Modeling;Mosaicism;Mothers;multidisciplinary;multimodality;Mus;Mutation;National Institute of Child Health and Human Development;Nature;Network-based;novel;Pathogenicity;Pediatric Cardiac Genomics Consortium;Phenotype;Pilot Projects;Population;Pregnancy;Pregnancy loss;recruit;Recurrence;Reproductive Health;Reproductive Medicine;Research;Sample Size;Sampling;Short Tandem Repeat;Siblings;Site;Testing;tool;transcriptome sequencing;Untranslated RNA;Variant;variant detection;whole genome;Woman;Work

PROJECT_TITLE: Large scale genome sequencing and integrative analyses to define genomic predictors of recurrent pregnancy loss


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROGRAM NARRATIVE Biomarkers of aging are critical to effective research promoting the healthspan. There is a particularly urgent need for molecular biomarkers of brain aging; we propose novel research constructing a rDNAm clock in brain tissue in aging cohorts. The proposed Aims promise to yield novel tools to evaluate brain age, predict neurodegenerative disease risk, provide new insights into mechanisms underlying neurodegeneration, and identify/test interventions to delay brain aging.

PI_NAMEs: GRODSTEIN, FRANCINE  (contact);LEMOS, BERNARDO

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Age;age group;age related;Aging;aging biomarker;aging brain;aging mechanism;Alzheimer's Disease;Alzheimer's disease related dementia;Anterior;Autopsy;biological age;Biological Aging;Biological Markers;bisulfite sequencing;Blood;Blood specimen;Brain;brain health;Brain Pathology;Brain region;brain tissue;Calibration;Cessation of life;Childhood;Chronology;Clinical;cohort;Data;Dementia;Development;Dimensions;Disease;disorder risk;DNA Methylation;Elasticity;epigenetic clock;Epigenetic Process;epigenetic regulation;Genomic Segment;Genomics;healthspan;Heart Diseases;Human;human old age (65+);improved;Inferior;insight;internal control;Intervention;Link;Malignant Neoplasms;Memory;Metabolism;Methods;Methylation;molecular marker;mortality;multidimensional data;Mus;Nerve Degeneration;Nervous System Disorder;Neurobiology;Neurodegenerative Disorders;Neurological outcome;Neurons;neuropathology;novel;Occipital lobe;Older Population;Oranges;Participant;Pathway interactions;phenotypic data;Prefrontal Cortex;Publishing;Recommendation;religious order study;Reporting;Research;Ribosomal DNA;risk prediction;Severities;Site;Specimen;Temporal Lobe;Testing;Text;Tissues;tool;Training;trait;Translating;Variant;Work

PROJECT_TITLE: A Novel Epigenetic Clock for Brain Aging

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Women's Health Research

PHR: Project Narrative Infants born to mothers who are overweight or obese during pregnancy (70% of pregnant women) are more likely to have increased fat mass at birth, an important risk factor for childhood obesity which can be accompanied by childhood non-alcoholic liver disease (NAFLD). There are no effective interventions in obese pregnancies to significantly reduce fetal overgrowth, but we have shown that maternal triglyceride levels are much higher in obesity and triglycerides are stronger predictors than glucose for newborn fat mass and liver fat storage. In this community study, we will determine the role and timing of maternal fasting and post-meal triglycerides on newborn fat mass and liver fat and mechanistically examine placental transport and early fat cell development which may identify a novel strategy to prevent fetal overgrowth and childhood metabolic disease.

PI_NAMEs: BARBOUR, LINDA ANNE (contact);HERNANDEZ, TERI L

PROGRAM_OFFICER_NAME: BROCKWAY, HEATHER MARIE

PROJECT_TERMS: Accounting;Address;Adipocytes;adipose derived stem cell;Air;Attenuated;Birth;Birth Weight;Body mass index;boys;C-Peptide;Childhood;Clinical;Communities;Continuous Glucose Monitor;Data;Development;Diabetes Mellitus;Diagnosis;Diet;Discipline of obstetrics;Dose;Dual-Energy X-Ray Absorptiometry;early pregnancy;effective intervention;effective therapy;Exhibits;Fasting;Fatty acid glycerol esters;fatty acid oxidation;fatty acid transport;Fatty Acids;fetal;Fetal Growth;Fetal Macrosomia;Fetal Reduction;Fetus;Future;Gestational Age;Gestational Diabetes;girls;Glucose;glucose monitor;Goals;Growth;High Risk Woman;Hyperinsulinism;in utero;Infant;Insulin;Insulin Resistance;intergenerational;Intervention Trial;intrahepatic;Late Effects;Late pregnancy;Life;Lipase;lipid transport;lipidomics;Lipids;Liver;Magnetic Resonance Spectroscopy;maternal obesity;Measures;Mesenchymal Stem Cells;Metabolic Diseases;Metabolism;meter;Monitor;Mothers;newborn adiposity;Newborn Infant;non-alcoholic fatty liver disease;nonhuman primate;novel strategies;obese mothers;Obesity;obesity in children;obesity in pregnancy;obesity risk;Omega-3 Fatty Acids;Outcome;Overweight;Pancreas;Pathway interactions;Placenta;Plethysmography;portability;Predictive Value;Pregnancy;Pregnant Women;prevent;Production;Prospective cohort;Resistance profile;response;Retrospective Studies;Risk;Risk Factors;Risk Reduction;RNA;Role;Sampling;sex;Sex Differences;stem cells;subcutaneous;synergism;targeted treatment;Testing;Time;Triglycerides;Umbilical Cord Blood;Umbilical cord structure;Umbilicus;Weight;Weight Gain;Woman;Work

PROJECT_TITLE: Triglycerides as a Predictor of Newborn Subcutaneous and Liver Fat: Contributors to Fetal Fat Accretion in Obese Pregnancies

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Contraception/Reproduction;Genetics;Infertility;Neurosciences;Pediatric;Prevention

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: NARRATIVE (RELEVANCE) The proposal will: (1) establish a new and complementary paradigm for noninvasively studying genetic and environmental influences of the human brain that bridges animal and human studies; (2) contribute important foundational knowledge to the genetic and environmental determinants of reading phenotypes and other complex traits, and how neurobiological pathways such as the phonological and orthographic circuitries mediate these effects; and (3) ultimately provide important information about risk/protective factors, windows of opportunity to intervene, and developing early intervention and preventive strategies for reading disorders.

PI_NAMEs: HOEFT, FUMIKO  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Age;aged;Animal Experimentation;Animals;Behavioral;behavioral phenotyping;Behavioral Research;Biological;Biological Models;Black race;Brain;Brain region;Categories;Child;Cognitive;Complex;Conceptions;Creativeness;Daughter;design;Development;Developmental reading disorder;Dissociation;Dorsal;Early Intervention;egg;Environment;Environmental Risk Factor;Exposure to;Family;Family member;Fathers;Fertilization in Vitro;Formulation;Fostering;General Population;Genetic;Genetic study;Gestational surrogate;Human;Individual Differences;intergenerational;Intervention;Investigation;Knowledge;Language;language processing;Learning Disorders;Magnetic Resonance Imaging;Mathematics;Measures;Mediating;model organism;Mothers;multimodal neuroimaging;neural;Neurobiology;Neurocognitive Deficit;neurodevelopment;neuroimaging;Newborn Infant;non-genetic;novel strategies;offspring;Orthography;Outcome;Parents;Pathway interactions;Pattern;Phenotype;phonology;postnatal;prenatal;prenatal influence;Prevalence;Prevention strategy;Procedures;Process;protective factors;Protocols documentation;Publishing;Reading;Reading Disorder;recruit;Research;Risk;sex;Sex Differences;Site;skills;Son;sperm cell;success;Time;trait;Translations;transmission process

PROJECT_TITLE: Intergenerational Neuroimaging of Language and Reading Networks Using a Natural Cross-Fostering Design

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Brain cells communicate using electrical and chemical signals and measuring these is crucial to understanding brain function. However, there is no natural contrast mechanism that allows us "to see" these messages. This project aims to illuminate brain communication through developing novel classes of genetically-encoded fluorescent reporters and tracers to study the brain and unravel the functional basis of neural disorders at a level of detail that has not been accessible to date empowering us to develop novel treatments.

PI_NAMEs: ABDELFATTAH, AHMED  (contact)

PROGRAM_OFFICER_NAME: ALVAREZ, RUBEN PAUL

PROJECT_TERMS: Action Potentials;Amino Acids;Animals;Behavior;Brain;brain cell;Brain Mapping;Cell Communication;Cells;Chemicals;Communication;Coupled;Coupling;detection method;Directed Molecular Evolution;Disease;empowerment;Exhibits;Fluorescence;genetic payload;Health;Heart;Human;Image;improved;Lighting;Longitudinal Studies;Maps;Measures;Memory;Microdialysis;Microscope;Molecular Conformation;nanobodies;neural;neural circuit;neural network;Neurons;Neuropeptides;neurotoxicity;novel;optogenetics;Phage Display;Process;Protein Engineering;Proteins;Rabies virus;Reporter;Resolution;Role;sensor;Shapes;Signal Transduction;spatiotemporal;Spectrum Analysis;Structure;Synaptic Potentials;tool;Tracer;Translating;two-photon;Visualization;voltage

PROJECT_TITLE: Lighting up the brain: Optogenetic tools to record, trace, and manipulate brain circuits at cellular resolution


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative: Osteoporosis is a major public health burden. Current estimates indicate that 12 million people suffer from osteoporosis in the U.S. Osteoporosis is largely influenced by genetics. This project seeks to identify the genes influencing bone mineral density. Successful completion of this project will new therapeutic targets for the treatment of osteoporosis.

PI_NAMEs: FARBER, CHARLES R (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Address;Bayesian Network;Biology;bone;bone cell;Bone Density;Bone Diseases;bone fragility;Bone Marrow;Bone Resorption;bone strength;Bone Tissue;causal variant;Cell Culture Techniques;Cell Physiology;cell type;Complex;cortical bone;Data;Data Set;Disease;Etiology;Evaluation;fracture risk;Genes;Genetic;genetic information;genome wide association study;Goals;Homeostasis;Human;In Vitro;in vivo;innovation;International;Knock-out;Knockout Mice;Knowledge;Molecular;Mus;network architecture;new therapeutic target;novel;Osteoblasts;Osteoclasts;Osteoporosis;Persons;Phenotype;Play;population based;Prevention;Public Health;Regulation;Role;single-cell RNA sequencing;System;Testing;therapeutic target;trait;transcriptome sequencing;transcriptomics;Variant

PROJECT_TITLE: Informing Osteoporosis GWAS Using Networks

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Social Determinants of Health;Violence Research

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PUBLIC HEALTH RELEVANCE: Depressive illness is the leading cause of disability world-wide, and it frequently begins during adolescence. Child abuse/neglect is a major risk factor for depression, and depression resulting from abuse/neglect may be different from depression due to other causes. We will identify the brain changes in these two subtypes of depression in adolescents which will increase our understanding of their biological bases and improve treatment guidelines.

PI_NAMEs: RAO, UMA  (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: abuse neglect;Accounting;Adolescence;Adolescent;Adult;Adverse event;Affect;Age;Age of Onset;Algorithms;Amygdaloid structure;Anhedonia;Anisotropy;attributable risk;base;Behavioral;Biological;Brain;Characteristics;Child Abuse and Neglect;child depression;Clinical;clinical practice;Clinical Trials;Cognitive;Data;Depressed mood;depression model;depressive symptoms;design;Development;Diffusion Magnetic Resonance Imaging;Dimensions;disability;Disease;disorder risk;disorder subtype;Economic Burden;Emotional;Emotions;Ensure;Etiology;experience;Formulation;Functional Magnetic Resonance Imaging;Genetic;gray matter;Hippocampus;imaging study;improved;indexing;Individual;infancy;Knowledge;Magnetic Resonance Imaging;Major Depressive Disorder;maltreatment;Measures;Mental Depression;Mental disorders;Motivation;Multimodal Imaging;negative affect;negative mood;neglect;neural;neural circuit;neural model;neural network;Neurobiology;neuroimaging;Outcome;Participant;Phase;Phenotype;Play;positive emotional state;Prediction of Response to Therapy;Prefrontal Cortex;Process;Public Health;public health relevance;Race;Recording of previous events;recruit;response;Rest;reward processing;Rewards;Risk Factors;Role;rumination;Sampling;sex;Shapes;social;Socioeconomic Status;Stress;Subgroup;Symptoms;Testing;Theoretical model;tractography;treatment guidelines;Treatment outcome;treatment response;Ventral Striatum;white matter

PROJECT_TITLE: Effects of Childhood Maltreatment on Neurocircuitry in Adolescent Depression


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: WASHINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: RELEVANCE Worldwide, there are 36.9 million people living with HIV infection in 2017. A recent report show that HIV infected patients has twice the risk to develop cardiovascular disease and, globally the burden has tripled in the last 20 years. In patients with HIV infection, activation of the immune system and systemic inflammation have been associated as the main drives of cardiovascular events. In this proposal, we will investigate the underlying mechanisms driving vascular damage/inflammation during HIV infection by focusing in a component of the immune system, CD8 T cells that have vascular repair properties (angiogenic CD8 T cells, CD8 Tang) and HIV-driven T cell immune activation interferes with their function. The ultimate goal of the proposal is restore CD8 Tang function in HIV infected patients to reduce vascular inflammation and cardiovascular risk.

PI_NAMEs: CATALFAMO, MARTA L. (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Adaptive Immune System;Address;Angiography;Apolipoprotein E;Automobile Driving;Biology;Blood;Blood Platelets;Blood Vessels;Bone Marrow;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cells;Chronic;Coagulation Process;Coculture Techniques;Critical Pathways;Data;Data Reporting;Disease;Disease Progression;Endothelial Cells;endothelial dysfunction;endothelial repair;endothelial stem cell;Endothelium;Event;General Population;Generations;Goals;Granzyme;Health;HIV;HIV Infections;Homeostasis;Human;Immune;immune activation;Immune system;Impairment;In Vitro;in vivo;Infection;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;Injury;injury and repair;innovation;Knockout Mice;Knowledge;Link;Literature;Lung;Lymphocytic choriomeningitis virus;Magnetic Resonance Imaging;Mediating;Memory;Molecular;Molecular Target;mouse model;novel;PAR-1 Receptor;Pathway interactions;Patients;Peripheral;Persons;Phenotype;Physiological;progenitor;programs;Proliferating;Property;Proteinase-Activated Receptors;receptor;recruit;repaired;Reporting;Research;Risk;Role;Signal Transduction;Site;stem cells;Stream;Supporting Cell;System;systemic inflammatory response;T cell differentiation;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Thrombin;Thrombin Receptor;tissue injury;tissue repair;Tissues;Trauma;vascular inflammation;vascular injury;Vascular Permeabilities;Viral

PROJECT_TITLE: The impact of HIV driven T cell immune activation in angiogenic CD8 T cell function: the role of PAR1 signaling

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Nutrition;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because it will allow us to identify the brain processes that lead some smokers to lose behavioral control and start compulsive smoking in the presence of cigarette-related cues. Identifying the neural underpinnings of cue-induced compulsive behaviors is likely to foster the development of new treatments targeting the brain processes responsible for cue-induced cravings and cue- induced relapses. Hence, this project is relevant to the NIDA Behavioral and Cognitive Neuroscience Branch mission of identifying individual differences that are associated with increased risk for addiction and predict individual responses to interventions.

PI_NAMEs: VERSACE, FRANCESCO  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: addiction;Affect;Affective;Animal Model;Behavior;Behavior Control;Behavioral;Brain;Categories;Cigarette;Classification;cognitive neuroscience;Compulsive Behavior;craving;Cue-induced relapse;Cues;Data;deprivation;Development;Disease;drug seeking behavior;Eating;Eating Behavior;Event-Related Potentials;Food;Fostering;Funding;General Population;Goals;Grant;habituation;Hour;Human;Hyperphagia;improved;Impulse Control Disorders;incentive salience;Incentives;Individual;Individual Differences;individual response;individualized prevention;innovation;Intervention;Knowledge;Laboratories;Lead;Mission;Modeling;motivated behavior;Motivation;National Institute of Drug Abuse;neural;neurobehavioral;neurobiological mechanism;Neurobiology;neurophysiology;Neuropsychology;Neurosciences;Nicotine;Nicotine Withdrawal;non-smoker;Obesity;Participant;personalized medicine;pre-clinical;prevent;Process;Property;Public Health;Rattus;Relapse;relapse prevention;Research;response;Rewards;Risk;Smoker;Smoking;Smoking Behavior;smoking relapse;Stimulus;Strategic Planning;Substance abuse problem;targeted treatment;Testing;theories;Therapeutic Intervention;trait;Translating;Translational Research;Translations;United States;Vulnerable Populations

PROJECT_TITLE: Incentive salience and the neuropsychological underpinnings of cue-induced smoking relapse

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Efforts to examine the utility of alternate modalities for genetic results disclosure has widespread implications for how precision medicine research might yield direct health benefits for study participants. This study will be the first to examine the efficacy of an online self-guided program to return genetic results to a racial minority cohort population. Study results will provide empirical evidence on the effectiveness of alternate modalities for genetic results return, inform ongoing efforts to establish scalable approaches for effective return of genetic research results, and increase access to personal health information among African American women.

PI_NAMEs: PALMER, JULIE R;WANG, CATHARINE  (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Acceleration;African American population;African American Women;Age;All of Us Research Program;anti-cancer research;arm;black women;brca gene;Breast Cancer Genetics;Breast Cancer Patient;Clinical;clinical predictors;clinically actionable;cohort;Communication;comparative efficacy;Data;design;Development;Disclosure;Discrimination;Distress;DNA;Education;Effectiveness;efficacy evaluation;efficacy testing;empowerment;ethnic minority population;Exclusion;Family Cancer History;follow-up;Fright;Genes;Genetic;genetic counselor;genetic information;Genetic Models;Genetic Research;Genomics;Germ Lines;Goals;Health;Health Benefit;health literacy;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;improved;Individual;individualized medicine;insight;interest;Intervention;Knowledge;Learning;Licensing;Malignant Breast Neoplasm;Medical;Medicine;Modality;Modeling;novel;Participant;Patients;Penetrance;Phase;Population;precision medicine;Privacy;Process;programs;prospective;Prospective, cohort study;Provider;psychologic;psychosocial;Psychosocial Factor;Qualifying;Questionnaires;Race;racial minority;racial minority population;Randomized, Controlled Trials;Recording of previous events;Research;Research Personnel;Research Project Grants;research study;Sampling;Self Efficacy;sociodemographics;targeted sequencing;Telephone;Testing;tool;Uncertainty;Underrepresented Populations;United States;uptake;Woman;Women's Health;Women's study;Work

PROJECT_TITLE: Testing scalable communication modalities for returning breast cancer genetic research results to African American women


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Hematology;Kidney Disease;Pediatric

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Fibroblast growth factor 23 (FGF23) levels are elevated in early stages of chronic kidney disease (CKD) in children and they are associated with CKD progression and cardiovascular disease. Thus, strategies that lower or limit the rise of FGF23 may lead to a new paradigm for the treatment of CKD-Mineral Bone Disorder. Thus, early intervention that focuses on control of FGF23 may lead to correcting 1,25D deficiency with replacement therapy that is associated with further rise in FGF23 levels.

PI_NAMEs: SALUSKY, ISIDRO B. (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: absorption;active method;Adult;Aftercare;Age;Anemia;arm;Biochemical;Biopsy;bone;Bone Diseases;bone metabolism;bone turnover;Calcitriol;Calcium;Cardiovascular Diseases;cardiovascular effects;Cessation of life;Child;Childhood;Chronic Kidney Failure;Citrates;Clinical;cohort;Combined Modality Therapy;Data;design;Development;Dialysis patients;Dialysis procedure;Disease Progression;Dose;Double-Blind Method;Early Intervention;efficacy evaluation;Enteral;Erythropoietin;Ferrous Sulfate;fibroblast growth factor 23;Future;Hemoglobin;Hormonal;improved;indexing;Infrastructure;inhibitor;inorganic phosphate;intervention effect;Iron;iron deficiency;Iron deficiency anemia;iron metabolism;Kidney;Kidney Diseases;lanthanum carbonate;Left Ventricular Hypertrophy;Link;Metabolism;Minerals;multi-site trial;Normal Range;novel;novel strategies;novel therapeutic intervention;Patients;pediatric patients;Pharmaceutical Preparations;Physiologic calcification;Physiological;Placebos;Plasma;Population;premature;prevent;primary endpoint;Production;Randomized;randomized placebo controlled trial;randomized trial;Renal function;Replacement Therapy;Safety;secondary analysis;secondary endpoint;Secondary Hyperparathyroidism;Serum;standard of care;treatment strategy

PROJECT_TITLE: Phosphate binder therapy and chronic kidney disease in children


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Genetics;Nanotechnology;Orphan Drug;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE This project is focused to determine functional and clinicopathological significance of miR-345 as well as development of novel combination therapies involving miR-345 restoration and gemcitabine therapy. The dual- delivery nanoscale device (DDND) loaded with miR-345 and GEM therapy concurrently targets pancreatic tumor cells and its stroma as well as pancreatic cancer (PC) stem cells by downregulating SHH, Kras and MUC4 for efficacious treatment of PC thereby overcoming challenges associated with current PC therapies.

PI_NAMEs: RACHAGANI, SATYANARAYANA  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Address;aldehyde dehydrogenase 1;angiogenesis;beta catenin;Biodistribution;c-myc Genes;cancer cell;Cancer cell line;cancer stem cell;cancer therapy;CASP3 gene;CASP7 gene;Cell Line;Chemosensitization;chemotherapy;Clinic;Clinical;clinical application;Clinical Trials;cohort;Combined Modality Therapy;Complex;copolymer;Cytotoxic agent;Data;Development;Device Designs;Devices;Diagnosis;Diagnostic;Diffusion;Disease-Free Survival;Distant;Dose;Dose Limiting;Down-Regulation;Drug Combinations;Drug Kinetics;drug release kinetics;Drug resistance;drug sensitivity;Ectopic Expression;efficacious treatment;Electrostatics;Encapsulated;Endosomes;epithelial to mesenchymal transition;Epithelium;Extracellular Matrix;Future;gemcitabine;Genes;Goals;Growth;HIF1A gene;Human;humanized mouse;improved;In Vitro;in vivo;Invaded;KPC model;liposome vector;lymph nodes;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mesenchymal;microRNA delivery;MicroRNAs;Modeling;Molecular;Motility;mouse model;MUC4 mucin;Mus;Nanodelivery;nanoscale;nanotherapeutic;Neoplasm Metastasis;Normal Cell;novel;novel therapeutics;Organ;Organoids;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Intraepithelial Neoplasia;pancreatic neoplasm;pancreatic stellate cell;Pathogenesis;Pathologic;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;Play;pre-clinical;Prognosis;prognostic;Property;Reporting;Resistance;restoration;Role;self assembly;SHH gene;side effect;Signal Transduction;Signaling Molecule;Site;success;Survival Rate;symptomatic improvement;synergism;System;Temperature;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;therapeutic miRNA;therapeutic target;therapy outcome;therapy resistant;Tissues;Toxic effect;Treatment Efficacy;tumor;tumor growth;tumor progression;tumor xenograft;Up-Regulation;Vascular Endothelium;Work;Xenograft procedure

PROJECT_TITLE: Targeting tumor and its microenvironment using nanotherapeutics for pancreatic cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PHR: Project Narrative Acetylation of the histone protein H4 is one of the most essential epigenetic marks found in human chromatin. This mark is directly linked to age-related disorders, Alzheimer’s disease (AD) in particular. The proposed studies will lead to a better understanding of how recognition of this acetylation mark can be therapeutically manipulated and may help to develop new strategies to prevent or treat age-related illnesses.

PI_NAMEs: KUTATELADZE, TATIANA G (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Acetylation;Acetyltransferase;Affinity;age related;age-related disease;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Binding;Binding Proteins;Biological;Biological Assay;Calorimetry;Cell Physiology;Chromatin;chromatin immunoprecipitation;Complex;design;DNA Repair;Epigenetic Process;Etiology;Fingers;Fluorescence;Gene Expression;Genes;Genetic Transcription;Genomics;Histone Acetylation;Histone H3;Histone H4;histone methyltransferase;histone modification;Histones;homeodomain;Human;human disease;In Vitro;in vivo;insight;Length;Link;loss of function;Lysine;Malignant Neoplasms;Measures;Mediating;Methylation;Methyltransferase;Modeling;Modification;Molecular;Mutagenesis;mutant;Neurodegenerative Disorders;novel;Pathogenicity;Peptides;PHD Finger;Physiological;Plants;Play;Post-Translational Protein Processing;prevent;Protein Acetylation;Reader;Reading;Role;screening;Signal Transduction;Site;Specificity;Structure;Tail;Therapeutic;Titrations;Transcriptional Activation;Western Blotting;Writing

PROJECT_TITLE: Targeting acetylated histone H4 by MLL4

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Hematology;Immunotherapy;Nanotechnology;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE New treatments for solid tumors can induce immune cells to ‘eat’ cancer cells, but not without toxic side effects. To avoid these side effects, we have developed nanoparticles for delivering drugs very selectively into inflammatory immune cells that infiltrate solid tumors. Our studies will reveal the mechanisms by which these selective nanoparticles can deliver drugs into tumors like a ‘Trojan Horse,’ so that inflammatory immune cells are unleashed to eat solid tumors without unwanted toxicity.

PI_NAMEs: SMITH, BRYAN RONAIN (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: 4T1;Acceleration;Address;Anemia;Animals;anti-cancer;Anti-CD47;Antibodies;Apoptotic;Beds;Binding;Biological Assay;Blocking Antibodies;Blood;Breast Cancer Model;Breast Cancer therapy;cancer cell;cancer immunotherapy;CD47 gene;CD47-SIRPα;cell growth;Cell surface;Cell Survival;cell type;Cells;Charge;Chemicals;Clinical;clinical translation;cytokine;Dangerousness;Darkness;Data;Dendritic Cells;design;dosage;Drug Delivery Systems;Eating;Endocytic Vesicle;Endosomes;Enzyme Inhibitor Drugs;Equus caballus;Excision;Fluorescence Microscopy;Frequencies;High Pressure Liquid Chromatography;Homing;Human;Hyperbilirubinemia;Immune;immune cell infiltrate;Immune mediated destruction;Immune system;In Vitro;in vivo;in vivo evaluation;Incubated;Infiltration;Inflammatory;Inflammatory Infiltrate;inhibitor;innovation;intravital microscopy;Kinetics;Leukocytes;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Membrane;Methods;monocyte;mouse model;Mus;nanoparticle;nanoparticle delivery;nanotherapy;neoplastic cell;nonhuman primate;novel;NR0B2 gene;Oncology;overexpression;Pathway interactions;patient derived xenograft model;Penetration;Peptides;Phagocyte Bactericidal Dysfunction;Phagocytes;Phagocytosis;Phagocytosis Inhibition;Pharmaceutical Preparations;Physiological;prevent;Process;Protein Tyrosine Phosphatase;Protocols documentation;PTPN6 gene;PTPNS1 gene;receptor;receptor binding;Reticulocytosis;Rodent;Safety;side effect;Signal Pathway;Signal Transduction;single walled carbon nanotube;small molecule;small molecule inhibitor;Solid Neoplasm;spatiotemporal;Spectrum Analysis;Surface;Testing;Therapeutic;Toxic effect;trafficking;Translating;translational therapeutics;Translations;Treatment Efficacy;tumor;Tumor Burden;tumor growth;tumor progression;uptake;Visualization

PROJECT_TITLE: Macrophage-specific nanotherapy for breast cancer

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE This research has substantial public health relevance as it will greatly improve our understanding of how people with a common genetic variant on chromosome 17 are at risk for multiple neurodevelopmental, psychiatric, and neurologic conditions. This work will begin to identify the brain-level mechanisms contributing to risk for these disorders, establishing the groundwork for future studies to develop new potential therapeutic interventions.

PI_NAMEs: GANDAL, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: 11 year old;17q21;3-Dimensional;Adolescent;Adult;Alleles;Area;ATAC-seq;autism spectrum disorder;biobank;Biological;Brain;brain volume;British;Cell Differentiation process;cell growth;Cell Line;Cells;Chromatin;Chromosome 17;Clinical;clinical diagnosis;Code;Cognitive;cohort;Cohort Studies;Communities;Complex;Copy Number Polymorphism;Data Set;Development;Diagnostic;Disease;disorder risk;Dissection;Education;endophenotype;European;Female;fetal;functional genomics;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome wide association study;genomic profiling;Genomics;Genotype;Haplotypes;Heritability;Human;Human Genome;improved;Individual;insight;Linkage Disequilibrium;male;Measures;Mediating;Medical;Mental disorders;middle age;Molecular;multi-ethnic;nerve stem cell;Nervous System;neurobiological mechanism;Neurobiology;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuroimaging;Neurologic;Neurotic Disorders;Outcome;Pattern;Performance;Persons;phenome;Phenotype;Population;Post-Traumatic Stress Disorders;protective effect;Psychiatric Diagnosis;psychiatric symptom;Psychiatry;public health relevance;Recurrence;Regulation;repository;Research;Risk;Sampling;Schizophrenia;Science;sex;single cell ATAC-seq;single-cell RNA sequencing;Surface;Syndrome;Therapeutic Intervention;Tissue-Specific Gene Expression;trait;transcriptome;transcriptome sequencing;Variant;volunteer;Work

PROJECT_TITLE: Population-level and mechanistic dissection of 17q21 structural variant association with psychiatric traits


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Women living with HIV/AIDS (WLHA) who are also impacted by adulthood interpersonal violence and co- occurring mental health and/or substance use disorders, suffer from poor outcomes along the HIV care continuum. However, few interventions have been developed and tested that address trauma from interpersonal violence among WLHA. We propose to determine the efficacy and mechanisms of change for Women SHINE, a web-based trauma-informed peer navigation-psychoeducation social support program aimed at primarily improving ART adherence and secondarily improving PTSD symptoms and emotion regulation among WLHA who have experienced interpersonal violence (i.e., physical, sexual, and/or psychological abuse) in adulthood.

PI_NAMEs: STOCKMAN, JAMILA KINSHASA (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Address;Adherence;Adult;Affect;Affective;AIDS prevention;antiretroviral therapy;arm;California;Caring;cis-female;Clinic;Collection;comparison control;Continuity of Patient Care;coping;County;Distress;Effectiveness;efficacy evaluation;emotion regulation;emotional abuse;Emotions;Enrollment;Epidemic;experience;follow up assessment;Goals;Hair;HIV;HIV/AIDS;implementation cost;implementation intervention;improved;Individual;interpersonal trauma;Interpersonal Violence;Intervention;intimate partner violence;Link;Mediator;Medical;men;Mental Depression;Mental Health;Methods;Moods;new technology;Online Systems;Outcome;Participant;Pathway interactions;peer;Personal Satisfaction;Persons;physical abuse;pilot test;Population;Post-Traumatic Stress Disorders;preventive intervention;programs;Proliferating;psychoeducation;psychological violence;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Research;Resources;Sampling;Self Care;Self Efficacy;Services;Sexual abuse;sexual violence;skills;social stigma;social structure;Social support;structural determinants;Substance abuse problem;substance use;Substance Use Disorder;Support Groups;Surveys;Symptoms;syndemic;Technology;technology intervention;Testing;theories;therapy adherence;therapy design;transgender women;Transportation;Trauma;trauma exposure;treatment arm;Treatment outcome;Violence;violence exposure;Viral;web site;Woman;women of color;women's outcomes;Women's trial

PROJECT_TITLE: Addressing Trauma from Interpersonal Violence through a Web-based Peer Navigation-Social Support Intervention to Improve ART Adherence among Women


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Prevention;Stroke

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Approximately 70,000 Americans suffer from a brain hemorrhage each year. Although brain hemorrhage is a major cause of death and permanent disability, a substantial number of patients may be able to function independently afterwards and would benefit from avoiding a recurrent and disabling hemorrhage. This project aims to investigate possible ways to decrease the recurrence of brain hemorrhage in patients who survive their first hemorrhage. It can have important clinical implications to improve the welfare of these patients and their families; and to minimize healthcare-related expenses.

PI_NAMEs: SELIM, MAGDY H (contact)

PROGRAM_OFFICER_NAME: AFZAL, MARIAM MASHEEB

PROJECT_TERMS: Address;American;Apolipoprotein E;Area;Arterial Occlusive Diseases;Benefits and Risks;Biological Markers;Blinded;Blood Vessels;Brain hemorrhage;Cardiovascular system;Cause of Death;Cerebral hemisphere hemorrhage;Cessation of life;Clinical;Cognitive;cognitive testing;Coronary;Cost Savings;Data;Decision Analysis;Disabling;efficacy outcomes;Equipoise;EuroQOL;Event;Family;follow-up;functional disability;Genotype;Healthcare;Hemorrhage;high risk;Impaired cognition;improved;Incidence;Individual;Ischemic Stroke;Knowledge;Lifelong disability;Link;Lobar;Magnetic Resonance Imaging;Myocardial Infarction;National Institute of Neurological Disorders and Stroke;Neurological disability;open label;Outcome;patient subsets;Patients;Peripheral;Peripheral arterial disease;Pharmaceutical Preparations;Phase III Clinical Trials;prevent;Prevention;Procedures;prospective;Public Health;Quality of life;Questionnaires;Randomized;Recurrence;Relative Risks;Research;Retina;revascularization;Risk;Risk Reduction;risk stratification;safety outcomes;stroke patient;Survivors;Telephone;Uncertainty;United States National Institutes of Health;welfare

PROJECT_TITLE: StATins Use in intRacerebral hemorrhage patieNts (SATURN)


NIH_SPENDING_CATS: Aging;Chronic Pain;Clinical Research;Neurosciences;Pain Research;Prevention

PHR: PROJECT NARRATIVE Chronic pain is a leading cause of disability in the US and globally, yet management options are limited and fundamental knowledge regarding causes of co-occurrence of multiple chronic pain conditions and neurophysiologic alterations in pain processing is lacking. Our grant creates an innovative inter-disciplinary collaboration to study the co-occurrence of multiple chronic pain conditions in middle age and older adults, focusing on potential common underlying causes, risk factor profiles, and heritability. The proposed work will bring new insights into chronic pain as a condition itself regardless of anatomic location of pain, with an aim to help the millions of American suffering from chronic pain.

PI_NAMEs: BENJAMIN, EMELIA J.;EDWARDS, ROBERT R;NEOGI, TUHINA  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Abdominal Pain;Address;Adult;Affect;Age;aged;American;Anatomy;Arthralgia;Autonomic Dysfunction;Autonomic nervous system;Back Pain;Body part;Chronic;chronic pain;chronic painful condition;cohort;Cohort Studies;Communities;cost;cost estimate;Data;Degenerative polyarthritis;Development;Diagnosis;disability;Disease;Electrocardiogram;Epidemiologist;Evolution;experience;follow up assessment;Framingham Heart Study;Functional disorder;Generations;Genetic;Genotype;Grant;Health;Health Personnel;heart rate variability;Heritability;High Prevalence;high risk;Impairment;Incidence;innovation;insight;interdisciplinary collaboration;International;Knowledge;Light;Location;Measures;middle age;Migraine;multidisciplinary;multisensory;Nature;Nervous System;Nervous System Physiology;neurophysiology;Nociception;novel;novel strategies;offspring;older adult;opioid epidemic;optimism;Pain;Pain management;Pain Measurement;pain processing;Participant;Pathway interactions;Patient Self-Report;Patients;Physical activity;Physicians;Preventive;Psychologist;resilience;rheumatologist;Risk;Risk Factors;risk sharing;Sensory;Severities;Signal Transduction;Sleep;sleep quality;Smell Perception;Social support;sound;Specialist;Spirituality;Stimulus;Testing;Therapeutic;Time;Visit;Work

PROJECT_TITLE: PRROPS:  Pathways of Risk and Resilience for Overlapping Pain and Sensitization


NIH_SPENDING_CATS: Aging;Clinical Research;Estrogen;Menopause;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Over 1.4 million postmenopausal women in the U.S. suffer an osteoporotic fracture yearly, resulting in disability and even mortality. This project will contribute to a long-term research agenda that seeks to determine if preventing rapid loss of bone mineral density (BMD) during the menopause transition (MT) and early postmenopause reduces the risk of osteoporotic fracture later in life; its specific contribution will be to examine whether we can predict accelerated BMD loss during the MT and early postmenopause before it occurs. This program of research, if successful, could ultimately redefine the way that we prevent fractures, by newly targeting high-risk women for early prevention prior to substantial BMD loss.

PI_NAMEs: SHIEH, ALBERT  (contact)

PROJECT_TERMS: Acceleration;Address;Affect;bone;Bone Density;bone loss;Bone Resorption;bone turnover;C-telopeptide;Circulation;Clinical Research;clinical risk;Clinical Trials;Collagen Type I;Cyclophosphamide;Data;disability;Early Intervention;efficacy testing;Equilibrium;Ethnic Origin;experience;Foundations;Fracture;fracture risk;Future;high risk;High Risk Woman;improved;indexing;Individual;individual variation;Intervention;Investigation;Lead;Life;Longitudinal Studies;Measures;Menstruation;Midlife women;mortality;multi-racial;N-telopeptide;novel;Osteocalcin;Osteogenesis;osteoporosis with pathological fracture;Ovarian aging;Participant;Perimenopause;Postmenopause;predictive tools;preservation;prevent;Prevention;preventive intervention;Probability;programs;prospective;Publishing;Recommendation;Research;Risk;Risk Factors;Risk Reduction;Serum;Serum Markers;Skeleton;Study of Women's Health Across the Nation;Testing;Time;tool;Translating;Type I Procollagen;Urine;Woman;Women's study;Work

PROJECT_TITLE: Predicting Fast Bone Mineral Density Decline and Fracture Across the Menopause Transition


NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative: This work examines the impact of SUMO modification on the biogenesis vs. degradation of the cystic fibrosis (CF) gene product, CFTR. Most CFTR mutations cause misfolding and premature degradation of the protein, preventing its trafficking to the apical membranes of epithelial cells. Understanding the ability of SUMO to increase CFTR biogenesis will enhance our knowledge of the CFTR folding pathway and support therapeutics development for CF.

PI_NAMEs: GOETZMAN, ERIC S (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Acetylation;Apical;apical membrane;Autophagocytosis;Behavior;Binding Proteins;Biochemical;Biogenesis;Biological Assay;Biology;Biophysics;bronchial epithelium;Cell membrane;Cell surface;Cells;Clinical;Clinical Research;Complex;Conflict (Psychology);Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Cytoplasm;Data;Deacetylase;Defect;Delta F508 mutation;density;Dependence;Disease;Endoplasmic Reticulum;Enzymes;Epithelial Cells;Facebook;Friends;gene product;Generations;HDAC6 gene;Heat shock proteins;Histone Deacetylase;Human;Integral Membrane Protein;Knowledge;Length;Ligation;Link;Mass Spectrum Analysis;Mediating;Mediator;misfolded protein;Modification;Molecular Chaperones;Molecular Conformation;Mutagenesis;mutant;Mutation;novel;novel strategies;Outcome;paralogous gene;Pathway interactions;Peptide Hydrolases;Phenotype;Phosphorylation;Physiologic pulse;posters;premature;prevent;Production;protein aggregation;protein complex;protein degradation;protein folding;Protein-Folding Disease;Proteins;Proteolysis;proteostasis;Quality Control;rare variant;Recycling;Reporting;response;Role;Scheme;Site;small molecule;Sumoylation Pathway;Support System;System;therapeutic development;Thermodynamics;trafficking;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Variant;VX-809;Western Blotting;Work

PROJECT_TITLE: Chaperone Actions in CFTR Biogenesis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Aging;Kidney Disease

ORG_CITY: Columbus

ORG_DEPT: SURGERY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Age-related decline of renal function reflects the reduced capability of the kidney to repair or regenerate in response to stress. By defining the fundamental biology that governs the muscle-kidney crosstalk, we aim to translate the basic findings of a novel tissue repair protein named MG53 into treatment of age-related kidney diseases.

PI_NAMEs: LIN, PEI-HUI  (contact);ROVIN, BRAD H

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Ablation;Acute Renal Failure with Renal Papillary Necrosis;Age;age related;age related decline;Aging;aging process;aging related;Antibiotics;Attenuated;Biochemical;Biology;Biomedical Research;canine model;Cell membrane;Cellular Structures;Chronic;Chronic Kidney Failure;Circulation;Communication;coping;cytokine;Disease;Doxycycline;Elderly;Engineering;Epithelial Cells;Epithelium;Exercise;Exposure to;Fibrosis;Functional disorder;Genes;Geriatrics;Health;Human;Individual;Infiltration;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injury;injury and repair;Injury to Kidney;Interleukin-1 beta;Intravenous;Intravenous infusion procedures;Ischemic Preconditioning;Kidney;Kidney Diseases;kidney fibrosis;kidney preservation;Knock-out;Limb structure;Link;live cell imaging;Macrophage;Mediating;Molecular;mouse model;Multicellular Process;Mus;Muscle;Myeloid Cells;Names;Natural regeneration;novel;old mice;Operative Surgical Procedures;Organ;Pathology;Physical Exercise;Physiological;Physiology;Play;Predisposition;preservation;prophylactic;protein function;Proteins;Recombinants;Rejuvenation;Renal function;repaired;Research;response;Role;Signal Transduction;Skeletal Muscle;Stress;Testing;Therapeutic;tissue repair;Tissues;TNF gene;tool;Translating;Transplantation;Tubular formation;Ureteral obstruction;welfare

PROJECT_TITLE: Muscle-Kidney Crosstalk in Age-related Kidney Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Parkinson Disease (PD) is a progressive movement disorder characterized by the dysfunction and loss of neurons which release the neurotransmitter dopamine. Recent evidence suggests that abnormalities in non- neuronal cells in the vicinity of dopaminergic neurons can influence their survival. The experiments in this proposal aim to determine the mechanisms by which a glial-enriched PD-risk gene influences dopaminergic viability, giving novel insight into the pathways by which glia support dopaminergic neuron survival in health and disease.

PI_NAMEs: COWELL, RITA MARIE (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: Acute;Age;Aging;alpha synuclein;Astrocytes;Autopsy;Behavior;Bioinformatics;Biological Availability;Brain;carbohydrate metabolism;cell type;Cells;Cellular Stress;Characteristics;Data;Disease;disorder risk;DNA Repair;Dopamine;dopaminergic neuron;Down-Regulation;Enzymes;Equilibrium;Etiology;Evaluation;Exhibits;experimental study;extracellular;Extracellular Space;Functional disorder;Gene Expression;Genes;Genetic Transcription;Genetic Variation;genome wide association study;Health;Heterozygote;Homeostasis;Human;Immune;immune cell infiltrate;Impairment;Inflammation;Inflammatory;Inherited;Injections;insight;Knockout Mice;Laboratories;Lewy Bodies;Lewy neurites;Link;Lipopolysaccharides;Maintenance;Mediator;Messenger RNA;Microglia;Mitochondria;mitochondrial dysfunction;Modeling;Motor;mouse model;Movement Disorders;mRNA Expression;Mus;Mutation;Neuroglia;Neurologic;neuron loss;neuronal survival;Neurons;neuropathology;neurotransmitter release;Niacinamide;Nicotinamide adenine dinucleotide;nicotinamide-beta-riboside;novel;Ontology;Oxidative Stress;Parkinson Disease;Pathogenesis;Pathway interactions;Patients;Peripheral;Phenotype;prevent;Process;Production;Proteins;Quantitative Trait Loci;Reaction;reconstitution;Regulation;Research Personnel;response;risk variant;Role;Single Nucleotide Polymorphism;Sirtuins;Source;Substantia nigra structure;Synapses;synaptic function;synucleinopathy;Testing;Tissues;trafficking;Transcript;Vesicle;Work

PROJECT_TITLE: Glial Involvement in REDOX Homeostasis in the Substantia Nigra

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Immunotherapy;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Patients with undifferentiated pleomorphic sarcoma (UPS), the most common cancer of soft tissue in older adults, frequently suffer from incurable disease recurrence. Immunotherapy combined with radiation is a promising alternative for these patients, but its efficacy is impeded by myeloid cells that infiltrate UPS tumors. Using mouse models and a clinical trial, the candidate will study a virus-like compound to redirect these myeloid cells, addressing a major obstacle to the success of immunotherapy and radiation for patients with UPS.

PI_NAMEs: KALBASI, ANUSHA  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: 3-Dimensional;Address;Adjuvant Study;Adopted;Adoptive Transfer;Adult;anti-PD-1;Antigen Presentation;Antitumor Response;Ants;Area;Atypical lymphocyte;Autologous;bench to bedside;Bone Marrow;cancer immunotherapy;career;career development;Cells;Cellular biology;chemotherapy;Clinical;Clinical Trials;Coculture Techniques;Combination immunotherapy;cytokine;Cytometry;Data;Dependence;Distant Metastasis;Double-Stranded RNA;Equation;Equilibrium;Equipment;Failure;Foundations;Frequencies;Genetic;Goals;high dimensionality;Human Resources;immune checkpoint blockade;Immune system;Immunity;Immunohistochemistry;immunoregulation;Immunosuppression;Immunotherapy;improved;In Vitro;in vitro Assay;Infiltration;Inflammatory;insight;Interferon Type I;Investigation;Knockout Mice;Literature;Localized Disease;Malignant Fibrous Histiocytoma;Malignant Neoplasms;Mediating;Mentors;Modeling;mouse model;Mus;Myelogenous;Myeloid Cells;nano;Neoadjuvant Therapy;Nivolumab;novel therapeutic intervention;older adult;Operative Surgical Procedures;participant enrollment;Pathway interactions;Patient Care;patient subsets;Patients;Phase;Phase I Clinical Trials;Phenotype;Poly I-C;Population;Productivity;professor;programmed cell death protein 1;programs;PTPRC gene;Radiation;Radiation Oncology;radiation response;Radiation therapy;recruit;Recurrent disease;Research;research and development;Research Personnel;Resources;response;restraint;Role;safety testing;Sarcoma;Signal Transduction;single-cell RNA sequencing;soft tissue;Soft tissue sarcoma;success;synergism;Systemic Therapy;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;three dimensional cell culture;Time;tool;Training;transcriptomics;translational immunology;tumor;tumor growth;Tumor Immunity;tumor immunology;Tumor Promotion;Tumor-Derived;Tumor-Infiltrating Lymphocytes;Undifferentiated;Virus

PROJECT_TITLE: Targeting Radiation-Induced Myeloid Cells to Promote T cell Immunity in Undifferentiated Pleomorphic Sarcoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: Suicide rates have increased rapidly in Veterans not using VHA care, particularly among females. Yet understanding of the reasons for these increases and how to address them is lacking. To address this knowledge gap, this study compares male and female Veterans who never used VHA care, were lost to VHA care after previous use, and who are currently using VHA care. We will examine if Veterans in these groups differ regarding: (1) circumstances and precipitants to suicide among suicide decedents; (2) mental health care experiences, barriers, and willingness to seek help; and (3) experiences, preferences, and barriers to help-seeking when suicidal. This mixed-methods study will link national datasets for suicide decedents, survey living Veterans, and conduct qualitative interviews of Veterans who have experienced suicidal ideation or suicide attempts. Gender differences will be examined to inform gender-sensitive, patient-centered suicide prevention efforts. Findings will be used to inform suicide prevention efforts for all Veterans, with an emphasis on non-VHA and female Veterans.

PI_NAMEs: HOFFMIRE, CLAIRE ;MONTEITH, LINDSEY LIH (contact)

PROJECT_TERMS: Address;Attention;barrier to care;Caring;Cessation of life;Characteristics;Clinical;clinically actionable;Communities;Data Linkages;Data Set;Distal;empowerment;Enabling Factors;Ensure;Epidemiological trend;evidence base;experience;Feeling suicidal;Female;Gender;gender difference;Health;health care service utilization;Health Services Accessibility;Health Services Administration;Healthcare;help-seeking behavior;Improve Access;improved;innovation;insight;Intervention;Interview;Knowledge;Link;male;Mental Health;Mental Health Services;Methods;Military Personnel;military veteran;Modeling;morphogens;Outcome;patient oriented;Policies;Population;Predisposing Factor;preference;Prevention;Prevention Research;Prevention strategy;Provider;Quality of Care;Recording of previous events;Records;reducing suicide;Reporting;Research;Sampling;Side;sociodemographics;socioeconomics;Source;stressor;Subgroup;suicidal;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surveys;Target Populations;Testing;trend;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;willingness;Work

PROJECT_TITLE: Preventing Suicide Among Female and Male Veterans Not Receiving VHA Services

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homicide and Legal Interventions;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Violence Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it is aimed at reducing racial disparities in sleep health, which translate into racial disparities in cardiometabolic health and health outcomes. The proposed research is relevant to the NIH mission of promoting research to improve minority health and advance scientific understanding of the causes of health disparities. The proposed research is relevant to the funding opportunity announcement PAR-17-234, “Mechanisms and Consequences of Sleep Disparities in the U.S. (R01),” given its focus on understanding how multilevel psychosocial determinants contribute to sleep disparities across the life course in health disparity populations.

PI_NAMEs: TSAI, ALEXANDER C (contact);VENKATARAMANI, ATHEENDAR S.

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Age;Black American;Boston;cardiometabolism;Chicago;Child;Cities;Coping Skills;Data;Data Set;Development;Disparity;ethnic disparity;experience;Funding Opportunities;General Population;Goals;Health;Health behavior;health disparity;health disparity populations;improve minority health;innovation;Intervention;Interview;killings;Knowledge;Lead;Life Cycle Stages;Link;Los Angeles;Maps;Measures;Mediating;Mental Health;Mission;Modeling;Modification;mortality;novel;Outcome;Pathway interactions;perceived discrimination;Philadelphia;Police;poor sleep;Population;population based;Population Study;Procedures;psychosocial;Public Health;Qualitative Research;Quasi-experiment;racial discrimination;racial disparity;racial health disparity;Research;Resolution;Scientific Advances and Accomplishments;sex;Sleep;Sleep Deprivation;sleep health;Structural Racism;Surveys;Testing;theories;Transcript;Translating;United States National Institutes of Health;Violence

PROJECT_TITLE: Racial disparities in police use of deadly force as a cause of racial disparities in sleep health across the life course


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Childhood Injury;Clinical Research;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE The number of impacts to the head in contact sports, like American football, is reportedly very high. Increasing evidence shows that effects of repetitive blows to the head are cumulative and can cause deterioration of brain structure and function. This study will use advanced neuroimaging, biomechanical techniques and neurocognitive assessments to examine brain structure and function changes in two contract sports (football or soccer) middle school and high school players after exposure to repetitive head impacts during two consecutive routine game and training seasons, in comparison with matched non-contact sports athletes.

PI_NAMEs: MCCREA, MICHAEL A;WANG, YANG  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: 3-Dimensional;Affect;Age;age effect;age group;American;arterial spin labeling;Biomechanics;Brain;Brain Concussion;Brain Injuries;career;Cerebrovascular Circulation;Cerebrum;Child;Clinical assessments;clinical translation;clinically significant;Cognitive deficits;college;contact sports;Contracts;Data;density;Deterioration;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Dose;Evaluation;Exposure to;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Head;head impact;Health;high school;Incidence;Injury;innovation;Intervention;junior high school;Knowledge;Life;Link;Long-Term Effects;Longitudinal Studies;longitudinal, prospective study;Manufactured football;Maps;Measurable;Measures;Monitor;multimodality;Nature;neurobehavioral;Neurocognitive;neuroimaging;neuroimaging marker;neurophysiology;Neuropsychology;novel;Outcome;Pathologic;Play;potential biomarker;Probability;Process;Public Health;public health relevance;Recovery;Recurrence;Reporting;Research;Seasons;Soccer;Source;Sports;Structure;subconcussion;System;Techniques;Time;Training;translational impact;treatment response;Work;Youth

PROJECT_TITLE: Effects of Head Impact Exposure During Contact Sport on Middle School and High School Athletes

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Project Narrative  This is a competitive renewal application for a NIH R01 grant that has been continuously funded and remarkably successful for 22 years. The long-standing goals of this project are to understand the mechanisms of chemokines and their receptors in various pathologies and to translate such information into the development of new intervention strategies. We propose to extend our exciting discoveries to the development of new CXCR4- targeted stem cell mobilizers with optimized pharmacological and biological properties to further probe the structure-function relationship of CXCR4-ligand binding and signaling and as drug leads to develop new medicines for promoting stem cell-based tissue repairs.

PI_NAMEs: AN, JING  (contact);HUANG, ZIWEI

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Affinity;Agonist;Amino Acids;analog;Animal Model;Animals;Basic Science;Binding;Biological;Biological Assay;Central Nervous System Diseases;chemical synthesis;Chemicals;chemokine;chemokine receptor;Clinical Research;Complex;Computer Simulation;cost;Coupled;CXCR4 gene;CXCR4 Receptors;design;Development;drug development;Foundations;Funding;Goals;Grant;human migration;human model;In Vitro;in vivo;Intervention;Lead;Ligand Binding;Ligands;Maps;Medicine;migration;mimicry;Modification;Molecular Mechanisms of Action;Mus;nerve stem cell;Neurodegenerative Disorders;novel;Pathology;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Point Mutation;preclinical study;Progress Reports;Property;prototype;receptor;receptor binding;Receptor Signaling;Regenerative Medicine;screening;Series;Signal Transduction;Site;Site-Directed Mutagenesis;small molecule;Solid;stem cell migration;stem cells;Structure;Structure-Activity Relationship;Therapeutic;therapeutic development;Therapeutic Effect;tissue repair;Translating;Translational Research;Transmembrane Domain;United States National Institutes of Health

PROJECT_TITLE: Structures and Interactions of Chemokine Receptors

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE We will use male and female rat pups to study inflammation in the young brain after traumatic brain injury (TBI). TBI is the leading cause of acquired disability in children, yet no effective therapies exist. Our results will inform future testing of Docosahexaenoic Acid (DHA), a promising therapy, in children after TBI.

PI_NAMEs: SCHOBER, MICHELLE ELENA (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acquired disability;Acute;Affect;Age;Anatomy;Anti-Inflammatory Agents;Antioxidants;Binding;Biological Assay;Brain;brain cell;Caspase;Cell Death;Cell membrane;Cell Separation;Cells;Child;Childhood;Chronic;Clinical Trials;clinically relevant;controlled cortical impact;cytotoxic;Development;Diet;Docosahexaenoic Acids;Dose;Edema;effective therapy;Encephalitis;Essential Fatty Acids;experimental study;Family;Female;Flow Cytometry;Functional Magnetic Resonance Imaging;Future;Genes;glial activation;Growth;Histology;IFNGR1 gene;Immune;Impaired cognition;improved;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Injury;innovation;Interferons;Interleukin-1 beta;intraperitoneal;Knowledge;Learning;Lesion;Long-Term Effects;Macrophage;Magnetic Resonance Imaging;male;Measures;Mechanics;Mediating;Membrane Microdomains;Memory impairment;Messenger RNA;Microglia;Modeling;Molecular;morris water maze;NADPH Oxidase;Nervous System Trauma;Neurologic;Neurological disability;Neurological outcome;neuroprotection;novel;object recognition;Outcome;Outcome Measure;Oxidative Stress;Pattern;pediatric traumatic brain injury;Phagocytosis;Phenotype;pre-clinical;Production;protein biomarkers;pup;Rattus;Reactive Oxygen Species;Receptor Signaling;Recovery;research clinical testing;response;Secondary to;sex;sham surgery;Signal Transduction;STAT protein;STAT1 gene;STAT1 protein;TBI treatment;Testing;Therapeutic;Time;Tissues;TLR4 gene;TNF gene;tool;transcription factor;Traumatic Brain Injury;white matter injury

PROJECT_TITLE: Microglial Function and Neurologic Outcome in Rat Pups after Experimental Traumatic Brain Injury: Effects of Timing and Duration of Docosahexaenoic Acid Therapy

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Chronic neuropathic pain is a debilitating condition that occurs in 10% of the general population and in 40-70% of those with spinal cord injury. This research aims to identify a biomarker signature with high sensitivity and specificity that is prognostic of neuropathic pain after spinal cord injury. The research would contribute knowledge about the relationship between autoantibodies and neuropathic pain, and the application of this knowledge may pave the way for clinical studies utilizing non-opioid therapeutics aimed at reducing plasma autoantibody levels in order to hinder the development of neuropathic pain.

PI_NAMEs: HERGENROEDER, GEORGENE W (contact)

PROGRAM_OFFICER_NAME: ARUDCHANDRAN, RAMACHANDRAN NMN

PROJECT_TERMS: Acute;adverse outcome;antibody and antigen binding;Antigens;Archives;Area Under Curve;Autoantibodies;Autoantigens;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;biomarker panel;biomarker signature;Blood;Blood capillaries;Central Nervous System;Characteristics;Chronic;chronic neuropathic pain;Classification;Clinical;Clinical Data;Clinical Research;cohort;collapsin response mediator protein-2;conventional therapy;Development;Disease;Early Diagnosis;Early Intervention;Early treatment;Enrollment;experimental study;Future;General Population;Glial Fibrillary Acidic Protein;Goals;Human;Immune system;Immunoglobulin G;Individual;injured;Injury;International;Knowledge;Lesion;Light;Logistic Regressions;Mass Spectrum Analysis;Measures;Modeling;Molecular;Morbidity - disease rate;Needles;Neuropathy;Nociceptors;non-opioid analgesic;novel;Opioid agonist;Pain;pain scale;painful neuropathy;Patients;Persons;Phase;Phenotype;Physical activity;Plasma;predictive signature;Predictive Value;prevent;Prevention;prognostic;Prognostic Marker;prognostic signature;prognostic value;prospective;Proteins;Quality of life;Rank-Sum Tests;Receiver Operating Characteristics;Refractory;Rehabilitation therapy;Research;response;Risk;Rodent Model;Sampling;Sensitivity and Specificity;Signs and Symptoms;somatosensory;Spinal Cord;Spinal cord injury;Spinal cord injury patients;System;Techniques;Testing;Therapeutic;Therapeutic Effect;Time;Touch sensation;Two-Dimensional Gel Electrophoresis;Western Blotting;Work

PROJECT_TITLE: Discovery of Biomarker Signatures Prognostic for Neuropathic Pain after Acute Spinal Cord Injury