NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Eczema / Atopic Dermatitis;Infectious Diseases;Microbiome;Pediatric

ORG_DEPT: DERMATOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Atopic dermatitis is a very common disease with substantial morbidity, most prevalent among infants and children who are also colonized at high rates in the gut by Staphylococcus aureus. While S. aureus is known to contribute to atopic dermatitis pathogenesis, studies have primarily focused on S. aureus in the nares and on the skin, with little attention to S. aureus and other microbiota in the gastrointestinal tract. The proposed project aims to elucidate the contributions of gastrointestinal S. aureus and other gut microbiota to pediatric atopic dermatitis, thereby furthering our understanding of S. aureus colonization dynamics beyond the nares and skin, and potentially revealing novel therapeutic targets for the treatment of atopic dermatitis.

PI_NAMEs: KARAGOUNIS, THEODORA KATERINA (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 16S ribosomal RNA sequencing;Accounting;Adult;Affect;Age;Alleles;Atopic Dermatitis;Attention;Biology;burden of illness;Child;Childhood;Clinical;clinical phenotype;Clinical Trials;clinically relevant;cohort;Collection;Comparative Genomic Analysis;Core Facility;Cutaneous;Cytokine Gene;Data;density;Disease;Disease remission;Environment;Evaluation;Faculty;Failure;Feces;fitness;Flare;gastrointestinal;Gastrointestinal tract structure;Gene Expression;Genome;Genomics;Germ;Germ-Free;gut colonization;gut microbiome;gut microbiota;Health;high risk;Histologic;human subject;improved;in vivo Model;Individual;Infant;Inflammation;Inflammatory;Intestines;Measures;Mediating;Mentors;Microbe;Microbiology;microbiome;microbiome analysis;microbiota;Molecular Epidemiology;Morbidity - disease rate;mouse model;Mus;mutant;Mutation;new therapeutic target;novel therapeutic intervention;Pathogenesis;Patients;pediatric patients;Physicians;Population;Positioning Attribute;pressure;Probability;Quality of life;rectal microbiota;Rectum;Regulator Genes;Research;Research Personnel;Research Training;Role;sample collection;Sampling;Scientist;Severities;Site;Skin;Skin colonization;skin disorder;skin microbiome;Source;Staphylococcus aureus;stool sample;Swab;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Training;translational genetics;transmission process;Variant;Virulence;Work

PROJECT_TITLE: Contributions of gastrointestinal Staphylococcus aureus and other gut microbiota to pediatric atopic dermatitis

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: TAMPA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Project Narrative In this K99/R00 proposal, I will investigate the antagonism and bifunctionality of the dual E3 ligase TRIM25, a modulator of the innate immune response pathway. I will leverage my training in protein engineering, biochemistry, and immunology to investigate how the HPV viral protein E6 antagonizes TRIM25 (K99) and to understand the dual function of TRIM25 as a Ub and ISG15 ligase (R00). By understanding the molecular mechanism that dictates TRIM25 bifunctionality, we will gain valuable insight into the complexity and regulation of innate immune signaling as well as the mechanisms of ISG15 recognition, transfer, and substrate targeting.

PI_NAMEs: SMALLEY, TRACESS  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Ablation;Address;Advisory Committees;Advocacy;antagonist;Area;Award;Binding;Biochemistry;Biological Assay;Biology;Cancer Center;career development;Cells;Cellular biology;Communities;Coupling;Data;design;Deubiquitination;Directed Molecular Evolution;Enzymes;equity, diversity, and inclusion;experience;Fostering;Genes;Glean;Goals;Grant;Health;Human;Human Papillomavirus;Immune signaling;Immunology;Immunoprecipitation;Innate Immune Response;innovation;insight;Institution;Interferons;ISG15 gene;Knowledge;Leadership;Ligase;Maps;Mass Spectrum Analysis;Mediating;Mentors;Modification;Molecular;Mutation;Natural Immunity;novel;novel strategies;novel therapeutics;Papillomavirus Transforming Protein E6;pathogenic virus;Pathway interactions;Peptide Hydrolases;Phase;Play;Polyubiquitination;Positioning Attribute;Post-Translational Protein Processing;preference;Process;programs;Property;Protein Engineering;receptor;Regulation;Research;Research Personnel;Resources;Role;Scientist;Signal Pathway;Signal Transduction;Site;skill acquisition;structural biology;Substrate Specificity;symposium;System;Testing;therapeutic development;tool;Training;Tretinoin;TRIM25 gene;Ubiquitin;Ubiquitin Like Proteins;ubiquitin-protein ligase;Ubiquitination;Variant;Viral;Viral Physiology;virology;Yeasts

PROJECT_TITLE: Dual E3 ligase function of TRIM25 in modulating innate immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-8 (MK)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative This project aims to develop a novel method to facilitate discussions about end-of-life options among patients with Alzheimer's Disease and related Dementias (ADRD), their informal caregiver, and clinicians. We will first conduct interviews and administer surveys to identify the most important topics related to ADRD's progression, the ideal timing for discussions, and how other factors such as health literacy, race, ethnicity, religion, and education can influence such discussions. Since end-of-life conversations related to ADRD are challenging and advance care planning discussions are usually a solitary event, we will design and evaluate a shared medical appointment (SMA), which offers a sense of community where physicians have the liberty to continuously discuss sensitive topics with a group of patients and their informal caregivers to increase knowledge, awareness, and preparedness of end-of-life approaches.

PI_NAMEs: ALPERT, JORDAN M (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Advance Care Planning;Affect;Alzheimer's disease caregiver;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Appointment;Attitude;Awareness;caregiving;Caring;Characteristics;Charge;Chemicals;Communication;Communication Research;community based participatory research;Community Physician;Consult;Data;Decision Making;Dementia;design;Development;Devices;Diagnosis;discount;Disease;Disease Management;Disease Progression;Distress;Education;Educational Background;Educational Curriculum;Effectiveness;effectiveness evaluation;Elderly;end of life;end of life care;Environment;Ethnic Origin;Evaluation;Event;experience;Family;Family member;Freedom;Future;Goals;health communication;health literacy;Health Personnel;Healthcare;Heart failure;Hospice Care;hospice environment;Hospitalization;Hospitals;improved;informal caregiver;innovation;Insurance;interest;Interview;Knowledge;Learning;Malignant Neoplasms;Measures;Medical;medical appointment;Medication Management;Mentorship;Methods;mindfulness;Modeling;novel;optimism;Palliative Care;Participant;patient-clinician communication;Patients;Perception;Physical Restraint;Physicians;preference;Prevalence;prevent;provider communication;Qualitative Research;Quality of Care;Race;racial diversity;Randomized, Controlled Trials;Readiness;Recommendation;Religion;Religious Belief;Research;Research Methodology;Research Technics;Resources;response;Self Efficacy;Services;skills;social integration;Structure;Surveys;Symptoms;Terminal Disease;therapy development;Time;traumatic event;Trust;Tube;United States National Institutes of Health;user centered design

PROJECT_TITLE: Developing shared medical appointments for informal caregivers of Alzheimer’s and Dementia patients to improve knowledge, communication, and advanced planning

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: TEMPLE

ORG_NAME: OLIN TEAGUE VETERANS CENTER

ORG_STATE: TX

PHR: Depressive symptoms are common among Veterans and associated with significant impairment. Early intervention has the potential to improve mental health outcomes and restore functioning. Interventions delivered through the internet are ideally suited for early intervention as they can be completed remotely at any time, and thus minimize burden on Veterans, however the research examining their utility in Veterans is limited. This proposed project will examine the acceptability and effectiveness of Deprexis, a self-guided internet-delivered intervention, which targets depressive symptoms and associated functional impairments. The proposed work has great clinical utility, as it could provide a readily accessible, high- quality intervention for the many Veterans suffering from depressive symptoms, with the potential to improve functioning and long-term outcomes.

PI_NAMEs: PEARSON, RAHEL  (contact)

PROJECT_TERMS: Aftercare;Algorithms;Attenuated;Award;barrier to care;Behavior Therapy;Behavioral;career development;Caring;Chronic;Clinic;Clinical;Clinical Trials Design;Cognitive;common symptom;comorbidity;Competence;Complex;computerized;Computers;Control Groups;cost;Data;Depression screen;depressive symptoms;Development;Development Plans;Diagnosis;disability;Early Intervention;Effectiveness;effectiveness evaluation;Enrollment;Evaluation;experience;follow-up;functional disability;Functional impairment;functional improvement;functional restoration;Future;General Population;Health Services Accessibility;Healthcare;Healthcare Systems;Impairment;improved;Individual;insight;Institution;Internet;internet delivery;Intervention;Interview;K-Series Research Career Programs;Knowledge;Literature;Major Depressive Disorder;Measures;Medical center;Medical Records;medical specialties;Mental Depression;Mental Health;Mental Health Services;Mentors;military veteran;Morbidity - disease rate;mortality;Outcome;Outcome Measure;Patient Preferences;Perception;Personal Satisfaction;personalized medicine;Persons;Pharmaceutical Preparations;Positioning Attribute;Post-Traumatic Stress Disorders;preference;prevent;Primary Care;primary outcome;programs;psychologic;Psychopathology;Psychotherapy;Qualitative Research;Quality of life;Randomized, Controlled Trials;Recovery;Recovery of Function;Recurrent disease;rehabilitation research;Rehabilitation therapy;Research;research and development;Research Personnel;Resources;routine screening;Sampling;Services;Severities;Shame;social stigma;statistical and machine learning;Statistical Methods;suicidal risk;Suicide;symptomatology;System;system-level barriers;Techniques;Testing;Time;Training;treatment as usual;treatment effect;treatment optimization;treatment response;trial comparing;uptake;Veterans;Work

PROJECT_TITLE: A Randomized Controlled Trial of Deprexis; Evaluation of A Computerized Intervention to Decrease Depression and Restore Functioning in Veterans

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Headaches;Migraine;Neurosciences;Opioids;Pain Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Medication overuse headache (MOH) develops when migraine patients overuse acute migraine medications, resulting in a paradoxical increase in headache frequency and severity. Our lab has identified a novel mechanism for the treatment of MOH, by inhibiting the PAC1 receptor. The aim of this proposal is to develop novel PAC1 receptor blockers that can be used as a novel therapy for MOH.

PI_NAMEs: KATRITCH, VSEVOLOD ;MAJUMDAR, SUSRUTA ;PRADHAN, AMYNAH AMIR ALI (contact)

PROGRAM_OFFICER_NAME: BACHMAN, JULIA LYNN

PROJECT_TERMS: Abstinence;Acute;addiction;Affect;Affinity;allodynia;Analgesic Overuse Headaches;analog;Animal Model;antagonist;associated symptom;Auras;Behavior;Behavioral;Behavioral Model;Binding;Biological Assay;Brain;Cell Line;Cephalic;Chemicals;Chronic;chronic pain management;Clinical;clinically significant;Collaborations;Computer Models;Cyclic AMP;Data;design;Development;disability;Disease;Drug Design;Drug Kinetics;efficacy evaluation;Evidence based treatment;experience;Family;FDA approved;Frequencies;Goals;Grant;Headache;Headache Disorders;improved;In Vitro;in vivo;inhibitor;Lead;lead candidate;Ligands;Link;Migraine;migraine treatment;Modeling;mouse model;multidisciplinary;Neuropeptides;neuropsychiatry;non-opioid analgesic;novel;novel therapeutics;Opioid;opioid therapy;opioid use;opioid withdrawal;PACAPR-1 protein;Parents;Patients;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Physiological;pituitary adenylate cyclase activating polypeptide;Plasma;polypeptide;Population;Post-Traumatic Stress Disorders;Pre-Clinical Model;Prevalence;Quality of life;receptor;Refractory;Reporting;return to use;screening;Severities;small molecule;Structure;System;targeted treatment;Testing;Therapeutic;Transfection;triptans;Up-Regulation;Vasoactive Intestinal Peptide;vasoactive intestinal peptide 2 receptor;VIPR1 gene;virtual;Work

PROJECT_TITLE: Development of PAC1 receptor antagonists for the treatment of Headache Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-S (18)]


ADMINISTERING_IC: AT

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Complementary and Integrative Health;Genetics;Natural Products;Nutrition

ORG_CITY: STANFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE: Plants are the origin of many FDA-approved drugs and, as food, deliver a daily dose of drug-like compounds into our bodies. This project establishes an efficient strategy to decode the genomes of dietary and medicinal plants by activating and identifying hundreds of different biochemical programs in multiplexed assays. This work will help illuminate what molecules a plant can synthesize, allowing us to (1) make informed dietary decisions, (2) engineer the metabolic content of our food, and (3) produce high-value medicinal compounds.

PI_NAMEs: MCCLUNE, CONOR JAMES (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Acceleration;Address;Adopted;Anabolism;Animals;Anti-Inflammatory Agents;Biochemical;Biochemical Pathway;Biochemistry;Biology;Candidate Disease Gene;career development;Cell Separation;cell type;Cells;Cellular Assay;Cellular biology;Cephalotaxus;Chemicals;Chemistry;Chromatin;Classification;Clinical;Colchicine;Complement;Complex;Coniferophyta;Consumption;Coupling;CRISPR-mediated transcriptional activation;dark matter;design;dietary;Dissection;Dose;drug-like compound;Environment;enzyme pathway;Enzymes;experimental study;FDA approved;Food;functional genomics;Gene Activation;Gene Expression;Gene Expression Profile;gene synthesis;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Goals;Health;homoharringtonine;Hormones;Human;In Vitro;in vivo;Individual;Learning;Libraries;Location;Mammalian Cell;Measurement;Measures;Medicinal Plants;Medicine;Mentors;Mentorship;Metabolic;metabolic engineering;Metabolism;Methodology;microfluidic technology;Microfluidics;Morphine;multiplex assay;neurotoxic;Organism;Output;overexpression;Paclitaxel;pathogen;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Phase;Physiology;plant genetics;Plant Genome;Plants;Process;programs;Protoplasts;Research;Research Personnel;Resolution;Resources;Role;Science;Scientist;screening;single cell technology;single-cell RNA sequencing;small molecule;Sorghum;Source;Specialist;stressor;Structure;synthetic biology;Systems Biology;Taxus;Technology;Therapeutic;Tissues;Tobacco;Tomatoes;tool;Training;transcription factor;transcriptomics;Translating;Variant;Velbe;Wheat;Work

PROJECT_TITLE: Dissection of specialized metabolism in plants using multiplexed perturbation

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (04)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE The proposed project aims to develop the next-generation photoacoustic computed tomography through an ergodic relay (PACTER) device for noninvasive monitoring of cerebral metabolic rate of oxygen (CMRO2). This research will have a significant positive impact on public health by addressing the critical gap in noninvasive CMRO2 monitoring and providing clinicians with timely and crucial information for accurate diagnosis, personalized treatment, and surgical decision-making. The development of next-generation PACTER will significantly advance brain health assessment, improve medical outcomes, reduce healthcare costs, and open new horizons for intraoperative brain monitoring and advancements in optical imaging technologies.

PI_NAMEs: ZHANG, YIDE  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Acoustics;Address;Anesthesia procedures;Animal Model;attenuation;Biological;Blood flow;Blood Vessels;Blood Volume;Brain;brain health;brain metabolism;brain surgery;Carotid Arteries;Carrying Capacities;Catheterization;Catheters;Cerebrum;Child;chromophore;Clinical;cost;cost effective;cost effectiveness;Critical Care;Decision Making;design;detector;Development;Devices;Diagnosis;diffuse optical tomography;electric impedance;Elements;Ensure;Exhibits;Exposure to;Fick method;Functional Magnetic Resonance Imaging;Future;Generations;Goals;Health;health assessment;Health Care Costs;healthy volunteer;hemodynamics;Hemoglobin;Human;Image;imaging capabilities;imaging detector;imaging modality;Imaging Techniques;Imaging technology;improved;innovation;Internal jugular vein structure;Intraoperative Monitoring;Label;Lasers;Light;Lighting;Measurement;Measures;Medical;Medical Care Costs;Medical Imaging;metabolic imaging;metabolic rate;Metabolism;Methods;Monitor;Neurodegenerative Disorders;Neurologic;Neurology;neurosurgery;next generation;non-invasive monitor;novel strategies;operation;Operative Surgical Procedures;optical imaging;Outcome;Oxygen;Patient-Focused Outcomes;Patients;Penetration;Performance;personalized care;personalized diagnostics;personalized medicine;phantom model;photoacoustic imaging;Physiologic pulse;Physiological;Positioning Attribute;Positron-Emission Tomography;Public Health;Quality of life;Radiation;Radiation exposure;real-time images;Research;Research Personnel;Resolution;Risk;skills;spatiotemporal;Speed;standard measure;stroke-like outcome;Structure of jugular vein;Techniques;Technology;temporal measurement;Therapeutic Intervention;Time;Tissues;tomography;translational scientist;transmission process;Traumatic Brain Injury;Ultrasonics;ultrasound;Validation;validation studies;vector;Venous;Work;X-Ray Computed Tomography

PROJECT_TITLE: Next-generation photoacoustic imaging for real-time, non-invasive monitoring of brain oxygen metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (J1)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Networking and Information Technology R&D (NITRD)

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Cancer cells produce non-normal protein sequences, which can be exploited for immunotherapy and vaccines for tumor prevention. We will build a novel, publicly accessible informatics resource containing software for predicting these non-normal sequences (called neoantigens) from DNA or RNA sequencing data, and confirming their presence by integration with mass spectrometry-based peptide data, thereby accelerating research in this critical area of cancer treatment.

PI_NAMEs: GRIFFIN, TIMOTHY J. (contact);JAGTAP, PRATIK D;NESVIZHSKII, ALEXEY I

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Acceleration;Adoption;Affinity;Algorithms;Amino Acid Sequence;Amino Acid Sequence Databases;anti-cancer research;Area;Automobile Driving;Base Sequence;Binding;Bioinformatics;cancer cell;cancer therapy;cancer type;Cancer Vaccines;Clinical Data;Collaborations;Communities;Complement;Complex;Computer software;computerized tools;Coupled;Data;Data Analyses;Data Set;Development;DNA;DNA Sequence;DNA sequencing;Ecosystem;empowerment;experience;Feedback;Funding;Galaxy;Genomics;Goals;Human;Immune system;immunogenic;immunogenicity;Immunooncology;Immunotherapy;improved;Informatics;informatics tool;interest;Life;Liquid Chromatography;Major Histocompatibility Complex;Malignant Neoplasms;Mass Spectrum Analysis;Methods;multiple omics;neoantigens;next generation sequencing;novel;novel therapeutics;Oncology;Peptides;Persons;Post-Translational Protein Processing;predictive tools;Prevention;protein aminoacid sequence;Proteomics;prototype;Research;Research Personnel;Resource Informatics;Resources;RNA;RNA Sequences;Sampling;success;synergism;System;tandem mass spectrometry;Technology;Testing;Tissue Sample;tool;Training;Training Activity;transcriptome sequencing;transcriptomics;tumor;Tumor Antigens;tumor progression;usability

PROJECT_TITLE: The immunoPeptidoGenomic (iPepGen) informatics resource forimmuno-oncology research

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-5 (J1)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunization;Immunotherapy;Orphan Drug;Ovarian Cancer;Prevention;Rare Diseases;Vaccine Related;Women's Health Research

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: NARRATIVE Despite evidence that ovarian cancer is immune reactive, with tumor regression occurring in response to immune modulation, no immune therapy has advanced to routine clinical use. Here we propose to use proprietary technology to transform cancer cells into highly immunogenic pathogen mimetics. Validation of the vaccine in humanized mouse models and therapeutic efficacy of allogeneic vaccines will be studied.

PI_NAMEs: SERDA, RITA ELENA (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Actins;Adsorption;Agonist;Alleles;Allogenic;anti-cancer;Antigen Presentation;antigen processing;Antigen-Presenting Cells;Apoptotic;Ascites;Autoantigens;Autologous;cancer cell;Cancer Model;Cancer Patient;cancer therapy;Cancer Vaccines;CD8-Positive T-Lymphocytes;Cell Nucleus;Cell Physiology;Cell surface;Cells;Clinical;Clinical Research;clinical translation;Clonality;cost;CPG-oligonucleotide;Dehydration;Dendritic Cells;efficacy evaluation;efficacy testing;Haplotypes;HLA-A gene;Human;Human Biology;humanized mouse;Immune;immune activation;Immune response;Immunocompetent;immunogenic;immunoregulation;Immunotherapy;improved;in vivo;Irradiated tumor;large scale production;leukocyte activation;Lipid A;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Masks;Mediating;microbial;mimetics;Molecular;mouse model;Mus;neoplastic cell;novel;Outcome;pathogen;Patients;Pattern;Phagocytosis;Phosphatidylserines;Phospholipids;preclinical efficacy;preclinical study;pressure;Procedures;Process;Property;Proteins;Readiness;Resistance;response;Safety;Sampling;Signal Transduction;Structure;Surface;Surface Properties;T cell clonality;T cell response;T-Lymphocyte;Technology;Testing;therapeutic vaccine;Toll-like receptors;Treatment Efficacy;tumor;Tumor Antigens;tumor growth;Tumor Immunity;Vaccination;vaccine efficacy;Vaccines;Validation

PROJECT_TITLE: Preclinical Efficacy of Allogeneic and Human Silicified Cancer Vaccines

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-O (J1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRATIVE Drug discovery hinges upon the identification of compounds that can selectively alter the activity of a target protein or proteins. A challenge in identifying such compounds is the limited chemical space that can be practically synthesized and screened due to physical mass barriers. This proposal aims to develop novel shapeshifting drug-like compounds that overcome physical mass limitations as they possess the ability to interconvert internally and spontaneously, i.e. shapeshift, between multiple chemical structures with varying pharmacophore properties.

PI_NAMEs: STOWELL, MICHAEL H. B. (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Adopted;Affinity;Amines;Amino Acids;analog;Astronomy;Binding;Biological Assay;biophysical analysis;Carboxylic Acids;Chemical Structure;Chemicals;chymotrypsin;combat;combinatorial;Complex;CXCR4 Receptors;Cyclic Peptides;cycloaddition;Data;Development;Disease;Drops;drug discovery;drug structure;Drug Targeting;drug-like compound;Evaluation;forging;Glycine;Goals;GRB7 gene;high reward;high risk;Human;improved;Infection;instrument;Intervention;Isomerism;Libraries;Malignant Neoplasms;Metals;Methodology;Methods;milligram;Molecular;Multi-Drug Resistance;Nature;novel;novel therapeutics;Parents;peptide drug;Peptide Library;peptide structure;Peptide Synthesis;Pharmaceutical Preparations;pharmacologic;pharmacophore;Phase;Phosphotransferases;Physiological;Physiology;Positioning Attribute;Property;Proteins;Proteome;Resolution;Scientist;Shapes;Side;Signal Pathway;single molecule;small molecule;Solid;Specificity;Technology;Temperature;three dimensional structure;tool

PROJECT_TITLE: Shapeshifting Cyclic Peptides as Single Molecule Polypharmacological Drugs

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Visuomotor transformation is a critical process linking ethologically relevant visual information with appropriate behaviors, but little is known about its underlying circuit and molecular mechanisms. The objective of this research program is to establish Drosophila as a powerful model system to investigate the molecular determinants of circuit wiring underlying a visuomotor transformation using a combination of transcriptomics, connectomics, and physiology. Molecular mechanisms of synaptic specificity uncovered in this work will be applicable to brains of other animals, including mammals, and will provide a deeper understanding of human neurological disorders associated with impaired visuomotor processing.

PI_NAMEs: DOMBROVSKIY, MARK  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Affect;Animals;Atlases;Axon;Behavior;Behavioral;Biological Models;Brain;Candidate Disease Gene;candidate validation;cell type;Cells;Chromatin;Collaborations;connectome;Data;Data Analyses;Development;differential expression;Disease;Drosophila genus;Drosophila melanogaster;Electrophysiology (science);Esthesia;experimental study;extracellular;Eye;feature detection;Fiber;fly;Gene Expression Profile;gene regulatory network;Genes;Genetic;genetic manipulation;Genetic Screening;Genetic Transcription;Heterogeneity;Human;Impairment;Individual;insight;interest;Investigation;knock-down;Knowledge;large scale data;Ligands;Link;Location;Logic;Mammals;Measures;Mediating;Mental disorders;Mentors;Mentorship;Modeling;Molecular;Molecular Analysis;Molecular Genetics;molecular modeling;Motor;Movement;Nervous System Disorder;neural;neural circuit;Neurons;novel therapeutic intervention;optogenetics;overexpression;Pattern;Phase;Photic Stimulation;Physiology;Population;postsynaptic;postsynaptic neurons;presynaptic;presynaptic neurons;Process;programs;receptor;Regulation;Research;response;Role;Sampling;screening;Sensory;Signal Transduction;Signaling Molecule;single cell ATAC-seq;single-cell RNA sequencing;Specificity;Structure;Synapses;System;Testing;Time;Tissue-Specific Gene Expression;Training;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Vision;Visual;Visual Fields;visual information;visual motor;visual stimulus;Visual System;Weight;WNT Signaling Pathway;Work

PROJECT_TITLE: Molecular determinants of synaptic specificity underlying a visuomotor transformation

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (03)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Dental, Oral, and Craniofacial Disease;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Dentists may be the first and only providers who intimate partner violence survivors seek care from for their face, mouth, or teeth injuries. However, screening and diagnosis challenges exist. This study aims to leverage health informatics to develop a clinical decision support tool to streamline IPV screening for dentists.

PI_NAMEs: BANAVA, SEPIDEH  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adopted;Age;Alcohols;American Dental Association;Apical;Assessment tool;Award;care providers;care seeking;Caring;Case Management;Clinic;Clinical;Clinical Assessment Tool;clinical data warehouse;clinical decision support;Collaborations;Contusions;Data;Data Analyses;data integration;data repository;Databases;Decision Making;Decision Trees;Dedications;Dental;Dental General Practice;Dental Records;Dental Schools;Dentists;Development;Diagnosis;Documentation;Drug usage;Economics;Effectiveness;Electronic Health Record;electronic structure;Electronics;Emergency Medicine;empowerment;Ensure;Ethnic Origin;experience;Face;Facial Injuries;Feedback;Focus Groups;Fracture;Gender;Grant;human centered design;improved;Informatics;Injury;innovation;insight;Institution;Intervention;intimate partner violence;Jaw;Knowledge;Laceration;large language model;Letters;Machine Learning;Manuals;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Modeling;Modernization;Names;National Institute of Dental and Craniofacial Research;Natural Language Processing;neglect;Oral cavity;Oral health;Oral Surgeon;orofacial;Outcome;Patient-Focused Outcomes;Patients;Pattern;Persons;Phase;physical conditioning;Physicians;pilot test;Play;Predictive Value;Prevalence;Process;Protocols documentation;prototype;Provider;Public Health Informatics;Quality of Care;Race;Random Allocation;Recommendation;Records;Reporting;Research;Research Design;Research Methodology;Research Personnel;Resources;Rights;Role;screening;screening guidelines;Screening procedure;Screening Result;sex;skills;Specificity;Statistical Data Interpretation;Statistical Models;Structure;structured data;support tools;Surveys;Survivors;Techniques;Technology;Time;Tobacco;tool;Tooth Injuries;Tooth structure;Training;Trauma;Update;Visit;Work

PROJECT_TITLE: Using Informatics and Natural Language Processing to Develop a Clinical Decision Support Tool to Improve Intimate Partner Violence Diagnosis by Dentists and Assess its Feasibility and Acceptability

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Precision Medicine;Suicide

ORG_CITY: PORTLAND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative This study will employ cutting edge computational modeling of cognitive, behavioral, and environmental data, generated from large-scale, national mental health studies of youth, to enhance diagnostic and prognostic prediction for children with common forms of psychopathology. Effectiveness will be evaluated within pediatric and psychiatry clinic settings from several regions of the country. If successful, this work has the capacity to dramatically improve the efficiency and efficacy of child psychopathology identification and care.

PI_NAMEs: NAGEL, BONNIE J (contact);NIGG, JOEL T

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Address;advanced analytics;Affect;aged;alertness;Algorithms;Anxiety Disorders;Arousal;Attention;Attention deficit hyperactivity disorder;Behavior;behavior measurement;Behavioral;behavioral phenotyping;Caring;Child;Childhood;Classification;Clinic;Clinical;clinical care;clinical diagnostics;clinical predictors;clinical prognostic;Cognition;Cognitive;cohort;Complex;Computational algorithm;Computer Models;Computerized Medical Record;cost;Country;Data;Data Collection;Data Sources;Deterioration;Diagnosis;diagnosis standard;Diagnostic;diagnostic accuracy;Diagnostic tests;diagnostic value;Dimensions;Disruptive Behavior Disorder;Effectiveness;Emergency department visit;emotion dysregulation;emotion regulation;Emotional;Emotions;Evaluation;executive function;Face;follow-up;Goals;Hand;Harvest;high risk;Impairment;improved;indexing;informant;innovation;Laboratories;Learning;Location;Logic;machine learning model;Measures;Mental Health;Methods;Modeling;Mood Disorders;National Institute of Mental Health;Negative Valence;Neural Network Simulation;novel;novel diagnostics;Oregon;Outcome;outcome prediction;patient population;Patient Recruitments;Patients;person centered;Persons;Phenotype;Population;Positioning Attribute;Positive Valence;prediction algorithm;predictive modeling;Problem behavior;prognostic;prognostic value;prospective;prospective test;Psychiatry;Psychopathology;Readiness;Records;Recruitment Activity;Reproducibility;Research;research clinical testing;Resources;response;Role;Savings;service utilization;Site;substance use;suicidal;Symptoms;Testing;Time;trait;transfer learning;Underrepresented Populations;Underserved Population;Work;Youth

PROJECT_TITLE: Person-centered diagnostics and prediction for child dysregulatory psychopathology using novel phenotypes

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (01)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE This K23 project examines the optimal timing and route of amiodarone administration in out-of-hospital cardiac arrest due to an initial shockable rhythm, a condition that continues to have near 75% mortality in the United States. The proposed aims have the potential to produce evidence for multiple future testable alterations to the timing, route, and dose of amiodarone administration in shockable cardiac arrest that will inform treatment guidelines learned and used by nearly every healthcare professional in the United States. This application aligns with the objectives of the NHLBI on levering data science, optimizing therapeutic strategies, and using implementation research for improving health, in addition to having synergistic training aims to develop an independent physician-scientist.

PI_NAMEs: LUPTON, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Advanced Cardiac Life Support;Algorithms;Amiodarone;Animals;Anti-Arrhythmia Agents;Biological Availability;Blood;Blood Vessels;Cardiac Volume;career;career development;Caring;Circulation;Clinical Trials;Cluster randomized trial;cluster trial;cohort;Data;Data Element;Data Science;Dose;Drug Evaluation;Drug Kinetics;efficacy evaluation;Electric Countershock;Emergency medical service;Epinephrine;experience;feasibility trial;Funding;Future;Goals;Guidelines;Health;Health Professional;Heart Arrest;Hospitals;Human;implementation research;improved;improved outcome;Informed Consent;Infrastructure;innovation;Intervention;Intravenous;Learning;Lidocaine;Life;lipophilicity;Measurement;Measures;Methodology;mortality;multilevel analysis;National Heart, Lung, and Blood Institute;Neurological status;novel;Observational Study;optimal treatments;out-of-hospital cardiac arrest;Outcome;participant enrollment;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Physicians;pilot trial;Population;programs;Property;prospective;Publishing;Randomized, Controlled Trials;Recommendation;Recovery;Refractory;Research;Research Personnel;Resuscitation;Route;Scientist;secondary outcome;Serum;Shock;Study of serum;Subgroup;Techniques;Testing;Therapeutic;Time;Training;Translating;treatment guidelines;treatment strategy;United States;Ventricular Fibrillation;Ventricular Tachycardia

PROJECT_TITLE: Optimizing the Timing and Route of Antiarrhythmic Administration in Out-of-Hospital Cardiac Arrest

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Transplantation

ORG_CITY: EUGENE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF OREGON

PHR: PROJECT NARRATIVE Large craniofacial bone defects are challenging to heal without surgical intervention and often require bone grafting, which has variable clinical outcomes with limited metrics to predict healing outcomes. Patient-specific organoids and systemic immune cell profiling are promising tools to understand mechanisms regulating regenerative processes, yet to date these tools are not widely used to study craniofacial bone healing. The experiments outlined in this proposal will characterize a newly developed bone-like organoid, as well as the local and systemic immune response during healing of a craniofacial defect, to identify therapeutics to improve healing and develop predictive models of healing outcomes.

PI_NAMEs: ROMANOWICZ, GENEVIEVE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Adipose tissue;Advisory Committees;alternative treatment;Biological Markers;Biology;Biomedical Engineering;Biotechnology;Blood;Blood Vessels;bone;bone fracture repair;bone healing;Bone Regeneration;bone repair;Bone Transplantation;career development;Career Mobility;Cell Separation;Cells;Cellular Morphology;Clinical;Clinical Treatment;clinically relevant;commercialization;Communication;cost;craniofacial;Craniofacial Abnormalities;craniofacial bone;craniofacial tissue;cytokine;Data;Defect;Development;Development Plans;Differentiation Antigens;Dose;Drug Screening;Evaluation;experience;experimental study;Exposure to;Female;Femur;Flow Cytometry;Foundations;Gene Expression;Genes;Goals;Grant;Growth Factor;Harvest;healing;Healthcare;high-throughput drug screening;Histologic;Human;Immune;Immune response;immunomodulatory therapies;immunoregulation;improved;In Vitro;in vivo;individualized medicine;Infection;inflammatory milieu;Injectable;Intervention;Literature;long bone;male;Maxilla;Measures;Mentors;Mentorship;mesenchymal stromal cell;microbiome;microCT;mineralization;Modeling;nano-string;Natural regeneration;next generation;next generation sequencing;novel;novel therapeutic intervention;Operative Surgical Procedures;Oral cavity;oral microbiome;oral tissue;Organoids;Osteoblasts;Osteocytes;Osteogenesis;osteogenic;osteoimmunology;Outcome;Patient Care;Patient-Focused Outcomes;Patients;personalized medicine;Pharmaceutical Preparations;Phase;Population;predictive modeling;Process;programs;Proteomics;Rattus;regenerative;regenerative approach;regenerative therapy;repaired;Research;RNA;Science;screening;Sinus;Site;skills;soft tissue;stem cells;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Time;Tissue Engineering;Tissues;tool;Trauma;United States National Institutes of Health;Work

PROJECT_TITLE: Bone-like organoids to understand factors controlling local bone immune response and regeneration


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Acquired and familial cardiomyopathies are common and fatal diseases in which protein mutations and other factors disrupt the function of individual components of the contractile machinery and ultimately lead to heart failure; unfortunately, standard treatment options only address disease symptoms and attempt to arrest disease progression without addressing its mechanistic origin. The project I propose here leverages a unique platform that combines computational approaches (in silico) with stem cell technologies (in vitro) to model the fundamental mechanisms of cardiac muscle contraction and identify new therapeutic small molecules by studying the structural communication pathways of proteins that comprise the contractile machinery. A multiscale, interdisciplinary approach will track how critical failures of (and corrections to) the contractile machinery at the single molecule level give rise to failure of organized contractile units (sarcomeres), subcellular contractile organelles (myofibrils), and cardiomyocytes.

PI_NAMEs: CHILDERS, MATTHEW CARTER (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Acceleration;Actins;Actomyosin;Address;Affect;Affinity;Amino Acid Substitution;Amino Acids;Area;ATP Hydrolysis;Benchmarking;beta-Myosin;Binding;Binding Sites;Biochemical;Biological Assay;Biology;Cardiac;Cardiac Muscle Contraction;Cardiac Myocytes;Cardiomyopathies;career development;Categories;Cell Physiology;Cells;Clinical;Communication;Complex;computational platform;Computer Models;Computer Simulation;computerized tools;Contractile Proteins;CRISPR/Cas technology;Data;design;Development;Dilated Cardiomyopathy;Disease;Disease Progression;Disparate;dynamic system;Electrostatics;experience;Failure;Familial Hypertrophic Cardiomyopathy;Filament;Functional disorder;Genes;genetic regulatory protein;Goals;Grain;Heart Diseases;Heart failure;human induced pluripotent stem cells;Hypertrophic Cardiomyopathy;in silico;In Vitro;Individual;induced pluripotent stem cell derived cardiomyocytes;inherited cardiomyopathy;insight;interdisciplinary approach;Interdisciplinary Study;Kinetics;Lead;Machine Learning;Measurement;Measures;Mechanics;Mentors;Methods;Microfilaments;Missense Mutation;Modeling;Molecular;Molecular Analysis;Molecular Conformation;Molecular Target;Motor;Muscle;Muscle Cells;Muscle Contraction;mutant;Mutation;Myofibrils;Myosin ATPase;novel;novel therapeutics;Organelles;Pathology;Pathway interactions;Periodicity;Phase;Play;Post-Translational Protein Processing;predictive modeling;Process;Property;Protein Biochemistry;Proteins;recruit;Regenerative Medicine;Relaxation;Reporting;Research;research and development;Research Personnel;Research Project Grants;Resources;Role;Sarcomeres;Side;simulation;single molecule;skills;small molecule;small molecule therapeutics;standard care;stem cell biology;stem cell technology;stem cells;structural biology;Structure;Surface;Symptoms;System;targeted treatment;Testing;Therapeutic;Thick Filament;Thin Filament;Tissues;Training Programs;Translating;Universities;Variant;Ventricular Remodeling;Washington;Work;X ray diffraction analysis

PROJECT_TITLE: A multiscale computational and experimental platform to investigate cardiomyopathies and targeted therapeutics

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (JA)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Food Allergies;Nutrition;Prevention

PHR: Project Narrative Daily maintenance dosing during oral immunotherapy (OIT) for food allergy and the risk of comorbid eosinophilic esophagitis (EoE) are major burdens for food allergic individuals. Here we propose to reduce these burdens by determining the safety and efficacy of high concentration reduced-frequency OIT maintenance dosing regimens (network-wide project). Furthermore, we will characterize gastrointestinal features of food allergic individuals with and without EoE (CRC-specific project).

PI_NAMEs: CHINTHRAJAH, R. SHARON;SINDHER, SAYANTANI B. (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Abdominal Pain;Accidents;Adherence;Age;Allergens;Allergic;Anaphylaxis;Antigens;Basophils;Biopsy;CD4 Positive T Lymphocytes;Cells;Characteristics;Clinical;clinical heterogeneity;Clinical Trials;common symptom;comorbidity;Consumption;desensitization;Development;Diagnosis;Diagnostic Procedure;Disease;Dose;Economics;effective therapy;Emotional;Endoscopy;eosinophil;Eosinophilia;Eosinophilic Esophagitis;experience;Follow-Up Studies;Food;food allergen;food challenge;Food Hypersensitivity;Frequencies;gastrointestinal;gastrointestinal symptom;Gastrointestinal tract structure;Gene Expression Profile;Immune;Immunologics;immunotherapy clinical trials;improved;Incidence;Individual;individualized medicine;insight;Laboratories;Life Style;Longterm Follow-up;Maintenance;mast cell;Methods;Modification;Nausea;novel diagnostics;Older Population;oral immunotherapy;Outcome;Participant;Pathogenicity;Patients;Persons;Pilot Projects;Procedures;Process;prospective;Regimen;Risk;Safety;side effect;Site;success;Symptoms;Testing;Th2 Cells;Therapeutic;Tissues;treatment strategy;Vomiting

PROJECT_TITLE: Therapeutic and Mechanistic Insights in Food Allergy

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 PT-I (J2)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Social Determinants of Health

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE Coronary heart disease (CHD) is a leading cause of death globally, and accurate risk prediction is vital for early intervention. However, current polygenic risk scores (PRS) for CHD have limited predictive value, particularly for populations with diverse ancestries, due to underrepresentation in genomic studies. Exploiting multiple recently developed increasingly diverse biobanks with 2.1 million individuals, Dr. Tcheandjieu aims to address these disparities by developing population-specific CHD PRSs, tailoring risk prediction approaches to individuals based on their genetic background, susceptibility to traditional risk factors, and social and environmental context.

PI_NAMEs: TCHEANDJIEU, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: 9p21;Address;African;African ancestry;Age;Asian ancestry;biobank;Biomedical Research;California;Cardiovascular system;career;Cause of Death;Clinic;clinical practice;clinical risk;Complex;Coronary heart disease;Country;Coupled;Data;Detection;Development;Diabetes Mellitus;disease disparity;Disease susceptibility;Disparity;disparity reduction;Early Intervention;Environment;Environmental Risk Factor;Equity;European;European ancestry;Exclusion;Exhibits;experience;Frequencies;functional genomics;Future;Gene Frequency;Genes;Genetic;genetic architecture;Genetic Risk;genetic variant;Genetic Variation;Genomics;Goals;Haplotypes;Health;health equity;heart disease risk;Heritability;Historical Demography;Human Genome;Hyperlipidemia;Hypertension;improved;Indigenous American;Individual;innovation;Institution;Knowledge;Linkage Disequilibrium;Medicine;Mentors;Minor;Minority Groups;non-genetic;novel;Obesity;Outcome;Participant;Pattern;Performance;personalized risk prediction;Phenotype;polygenic risk score;Population;Population Genetics;Population Heterogeneity;portability;predictive tools;Predictive Value;Predisposition;Prevalence;prevent;programs;rare variant;Reduce health disparities;Research;Research Personnel;Resources;Risk;Risk Factors;risk prediction;risk variant;San Francisco;Scientist;sex;Single Nucleotide Polymorphism;social;social determinants;social epidemiology;social factors;sociodemographics;stem;Structure;Technology;Testing;tool;Training;United States;Universities;Variant;Work

PROJECT_TITLE: Addressing Disparities in Polygenic Risk Score for Coronary Heart Diseases in Diverse Populations

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (JA)]


ORG_CITY: COLUMBIA

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: SC

PHR: When mobility is limited, such as during severe illness or injury, muscles undergo a rapid loss in mass referred to as disuse atrophy. Atrophy decreases muscle strength and hinders the patient’s ability to rehabilitate, leading to functional disability which is exacerbated in aged populations. We are developing biodegradable, biocompatible particles for delivery to atrophied muscle. The particles are designed to promote the release of biomolecules that enhance muscle metabolism and growth. This innovative approach complements current rehabilitation strategies (e.g. physical therapy, nutritional support) and is expected to maximize functional recovery in aged patients, a population that struggles to recover from muscle atrophy secondary to disuse.

PI_NAMEs: GOWER, ROBERT MICHAEL (contact)

PROJECT_TERMS: Abbreviations;Acceleration;Address;age-related muscle loss;aged;aging population;Animals;Area;Atrophic;biomaterial compatibility;Caring;Cells;Clinical;clinical implementation;cytokine;Data;design;Development;disability risk;Disuse Atrophy;Drug Delivery Systems;Drug Formulations;Drug Prescriptions;Exhibits;Fiber;functional disability;Gene Expression;General Population;Genetic Complementation Test;Growth;Healthcare;Histologic;Human;Immobilization;Immunology;improved mobility;improved outcome;In Vitro;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;Insulin-Like Growth Factor I;Interleukin-6;Intervention;Kinetics;Leg;Locomotion;loss of function;Macrophage;mass spectrometric imaging;Molecular;Molecular Analysis;Monitor;Motor Activity;Mus;Muscle;Muscle Fibers;muscle form;Muscle function;muscle metabolism;muscle physiology;muscle regeneration;Muscle satellite cell;Muscle Weakness;Muscular Atrophy;Musculoskeletal;Natural regeneration;novel therapeutics;Nutritional Support;old mice;Operative Surgical Procedures;particle;Pathway interactions;Patients;Pharmacotherapy;Pharmacy (field);Phase;Phenotype;Physical therapy;Polymers;Population;Production;Protein Biosynthesis;Recovery;Recovery of Function;reduced muscle strength;regenerative;Regenerative response;rehabilitation strategy;Rehabilitation therapy;repaired;response;Rodent;Secondary to;Site;Skeletal Muscle;skeletal muscle wasting;System;Testing;Time;Tretinoin;ultrasound;Veterans;Work

PROJECT_TITLE: Macrophage targeted microparticles for the regeneration of atrophied muscle

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Project Narrative As a unique ethnic group in the US, Native Hawaiians exhibit increased incidence and mortality rates of colorectal cancer. The project addresses these disparities by using multiple approaches to define biological risk factors to improve prevention and clinical outcomes for Native Hawaiians who are stricken with colorectal cancer. This research carries the potential to make a meaningful impact on the well-being of Native Hawaiians and contribute to the overall goal of eliminating colorectal cancer disparities.

PI_NAMEs: FU, YUANYUAN  (contact)

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Address;Age;Biological;Biological Factors;Cancer Etiology;cancer health disparity;Candidate Disease Gene;Caucasians;Cessation of life;Characteristics;Clinical;cohort;Cohort Studies;colon cancer patients;Colorectal Cancer;colorectal cancer risk;Colorectal Neoplasms;Communities;Data;Death Rate;Detection;Development;differential expression;Disease;Disparity;DNA;DNA Damage;DNA Sequence Alteration;DNA sequencing;driver mutation;Early Intervention;early onset colorectal cancer;Environmental Risk Factor;epidemiologic data;Epidemiologic Factors;Epidemiology;ethnic minority;Ethnic Origin;Ethnic Population;Etiology;Exhibits;exome;Exons;experience;experimental study;Female;Gene Expression;Gene Mutation;Genetic;Genetic Predisposition to Disease;Genetic study;genetic variant;Genetic Variation;genome sequencing;Genomics;Goals;Hawaii;Hawaiian;Hawaiian population;Health;health disparity;high risk;high throughput technology;Human Genome;improved;In Vitro;Incidence;Inflammation;insight;Intervention;Investigation;Levocarnitine;Life Style;male;Malignant Neoplasms;Measurement;Measures;Mediator;Metabolic;Metabolic Pathway;metabolomics;Modeling;Molecular;mortality;mortality risk;multi-ethnic;Multiomic Data;Mutate;Mutation;Native Hawaiian;non-genetic;Normal tissue morphology;novel;Nutrient;Oncogenic;Outcome;Participant;Pathogenesis;Pathway interactions;Patients;Personal Satisfaction;Pharmaceutical Preparations;Phenylalanine;Plasma;Population;precision medicine;Predictive Value;Predisposition;Prevention;prognostic model;Race;racial population;Research;Resources;Risk Factors;risk prediction;RNA;Sampling;screening;Signal Pathway;Signal Transduction;social determinants;Somatic Mutation;Symptoms;Testing;The Cancer Genome Atlas;Therapeutic Intervention;Tissue Sample;transcriptome;transcriptome sequencing;transcriptomics;translational cancer research;tumor;Tumor Tissue;Validation;Variant;whole genome

PROJECT_TITLE: Identifying unique biological factors as potential targets to mitigate colorectal cancer health disparities in Native Hawaiians

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (J1)]


ADMINISTERING_IC: DP

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: SHAO, HUI  (contact)

PROJECT_TITLE: DP22-001 Real-world effectiveness of structured lifestyle interventions in preventing type 2 diabetes - 2022


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative Low frequency rhythms in human brain activity have been studied for 90 years and correlated with changes in attention, perception, and memory. However, it is still unknown if these rhythms actually change how the brain processes information, and, if they do, what these changes are. Here we propose to answer these questions by ﬁrst examining how endogenous rhythms alter the processing of visual information at the single cell and population level, and then by directly modulating these rhythms with electrical stimulation.

PI_NAMEs: GHOSE, GEOFFREY M (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Address;Affect;Afferent Neurons;Alpha Rhythm;area V4;Attention;Attention deficit hyperactivity disorder;attentional modulation;Behavior;behavior prediction;Behavioral;Brain;Cells;Cognition;Cognition Disorders;Decision Making;density;Detection;Development;developmental disease;Disease;Electric Stimulation;Electrocorticogram;Electrodes;Electroencephalography;experimental study;Frequencies;Human;Implant;improved;inattention;Individual;information processing;Knowledge;Link;Measures;Memory;Mental disorders;Methods;Monkeys;Neurons;neurophysiology;nonhuman primate;novel;novel therapeutic intervention;Pathology;Pathway interactions;Penetration;Perception;Performance;Phase;Physiological;Population;Prefrontal Cortex;Process;response;Role;Schizophrenia;Sensory;Shapes;Signal Transduction;Task Performances;Techniques;Testing;Therapeutic;Time;V4 neuron;Visual;Visual Cortex;visual information;visual processing;Work

PROJECT_TITLE: Modulating attention and decision making with closed loop control of low frequency oscillations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IFCN-J(58)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative This study will integrate a virtual reality driver system (VRDS) into a current clinical driving assessment program to evaluate and predict long term driving performance among individuals with brain injury. The study will include a 2 year follow-up and examine driving behaviors (i.e., errors, crash involvement) using web-based self-report, a driving sample monitored by in-vehicle technologies and reports from the Department of Motor Vehicles. The findings will define the utility of VRDS to current clinical approaches and generate predictive models of driving outcome, which can serve to benefit individuals with brain injury and the safety of the general public.

PI_NAMEs: SCHULTHEIS, MARIA TERESA (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Accidents;Address;Algorithms;Assessment tool;Automobile Driving;Behavior;Brain Injuries;Clinic;Clinical;Clinical assessments;Clinical Protocols;Communities;Complex;Consensus;Data;Data Reporting;Databases;driving behavior;driving performance;driving skills;Education;evidence base;experience;follow-up;Follow-Up Studies;General Population;Generations;Human;Individual;innovation;Intervention;Laboratories;Life;Literature;Measures;Methodology;Methods;Modeling;Modification;Monitor;Moods;Motor Vehicles;novel;Online Systems;Outcome;Outcome Measure;Output;Participant;Patient Self-Report;Pattern;Performance;Persons;Population;predictive modeling;Predictive Value;Process;Process Assessment;programs;Quality of life;Records;Reporting;Risk;Risk Behaviors;Risk Reduction;Safety;Sampling;simulation;Standardization;Statistical Data Interpretation;System;Techniques;Technology;Thinness;Training;virtual reality;Work

PROJECT_TITLE: Virtual reality driving and brain injury in the clinic

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Somatosensation and vision are crucial for functioning in daily life and can be lost due to various neurological injuries and diseases. While these senses can potentially be restored with stimulation of the sensory cortices, it is not currently well understood how stimulation affects the brain and drives activity. By studying the mechanisms of stimulation in mouse cortex using high-resolution imaging techniques, we aim to develop a better understanding of the basic science of neural circuits underlying sensory processing and how they are impacted by stimulation, which in the long-term will inform better technologies and clinical approaches.

PI_NAMEs: HUGHES, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acute;Affect;Animal Model;Animals;Automobile Driving;Basic Science;Blindness;Brain;BRAIN initiative;Calcium;career;career development;cell type;Clinical;Clinical Trials;Complement;Data;Devices;Disease;Disinhibition;Distant;Electrodes;Electrophysiology (science);Esthesia;excitatory neuron;expectation;experience;Frequencies;Future;Genetic;Goals;Hand;Health;high resolution imaging;Hour;Human;Image;imaging approach;imaging capabilities;Imaging Techniques;Imaging technology;Implant;implantation;improved;in vivo;in vivo calcium imaging;Individual;inhibitory neuron;Intervention;Investigation;Label;Life;Literature;Location;Measures;Methods;Michigan;microstimulation;mouse model;Mus;Nervous System Disorder;Nervous System Trauma;neural;neural circuit;neural recruitment;neuroimaging;neuromechanism;Neurons;neurophysiology;Outcome;Participant;Parvalbumins;Perception;Persons;Play;Population;recruit;Research;response;Rodent Model;Role;Scientist;Sensory;sensory cortex;sensory input;sensory neuroscience;sensory system;sight restoration;skills;Somatosensory Cortex;Somatostatin;Spinal cord injury;Stimulus;Structure;Techniques;Technology;tool;Training;Transgenic Mice;Transgenic Organisms;two photon microscopy;two-photon;Vision;Work

PROJECT_TITLE: Investigating the Recruitment of Different Neuronal Subpopulations by Intracortical Micro Stimulation Using Two Photon-Microscopy


NIH_SPENDING_CATS: Aging;Bioengineering;Cancer;Cancer Genomics;Colorectal Cancer;Data Science;Digestive Diseases;Genetics;Human Genome;Microbiome;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The proposed research will provide a substantial advancement in our ability to identify metabolites that are biomarkers for distinguishing between people with and without colorectal cancer, resulting in significant public health relevance. We seek to develop a new open source R package, mums2, which will broadly enable researchers to better understand the metabolome across a variety of diseases regardless of whether individual metabolites can be annotated.

PI_NAMEs: BALUNAS, MARCY J;SCHLOSS, PATRICK DAVID (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Adoption;Algorithms;American;Animal Model;anti-cancer research;Attention;Biological Assay;Biological Markers;Biology;biomarker identification;Black Box;Blood;Butyrates;Cancer Biology;Cancer Research Project;Cancerous;Cells;Chemicals;Chromatography;Clinical;Colon;Colonic Neoplasms;Colonoscopy;Colorectal Cancer;colorectal cancer progression;colorectal cancer screening;Communities;Complement;Complex;Computer software;cost;Data;Data Analyses;Data Set;Democracy;design;Detection;Diagnosis;diagnostic biomarker;Disease;DNA;dysbiosis;Early Diagnosis;Early treatment;Elements;Environment;Exclusion;fecal microbiota;Feces;Fees;Funding;Genetic Markers;Goals;gut microbiota;Health;Human;Human Microbiome;human population study;improved;in silico;In Vitro;Incidence;Individual;Industrialization;Informatics;interest;Licensing;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mass Spectrum Analysis;Metabolic;metabolic profile;Metabolism;metabolome;metabolomics;Methods;microbial;microbiome;microbiota;Modeling;Molecular Weight;mortality;Multiomic Data;Neoplasms;noninvasive diagnosis;open source;Patient Compliance;Pattern;Persons;Population;Prevention;public health relevance;R programming language;Reproducibility;Research;Research Personnel;Risk;Role;screening;Screening procedure;Signal Transduction;Source;Specimen;stool sample;Structure;synergism;Taxonomy;Techniques;Technology;Testing;Time;tool;tumor;Tumor Burden;tumorigenesis;Urine;Volatile Fatty Acids;Writing

PROJECT_TITLE: muMS2: an open source R package for analyzing and integrating multi-omics datasets to improve early detection and understanding of colorectal cancer


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Lung;Prevention;Pulmonary Hypertension;Rare Diseases

PHR: Project Narrative Using relevant translational approaches we will dissect how GP130 signaling modulates right ventricular function via microtubules in preclinical pulmonary arterial hypertension (PAH). Our findings will have broad implications for future treatment of PAH, a lethal disease with a median survival of only five to seven years. No current therapy targets the right ventricle directly; thus there is a critical need to define targetable molecular mechanisms that cause right ventricle disease so as to develop an effective therapy.

PI_NAMEs: PRINS, KURT W (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Address;Affect;Animal Model;antagonist;Architecture;Attenuated;Biology;Blood capillaries;Calcium;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;Cell Nucleus;Cessation of life;Chemicals;Chimeric Proteins;Colchicine;cytokine;Data;density;Disease;Dose;druggable target;effective therapy;Equilibrium;Failure;Family suidae;first-in-human;Functional disorder;Future;gastrointestinal;Genetic Transcription;Genus Hippocampus;Grant;Human;human disease;human study;IL6ST gene;improved;In Vitro;Inflammatory;Interleukin-6;junctophilin;Left;Lung;Measures;Mediating;Medical;Membrane Proteins;Metabolic;Metabolic dysfunction;Metabolism;metabolomics;Microtubule Stabilization;Microtubule stabilizing agent;Microtubules;Mitochondria;Modeling;Molecular;Molecular Probes;Monocrotaline;Morphology;mortality;Neurologic;new therapeutic target;Paclitaxel;Pathologic;Pathway interactions;Patients;pharmacologic;Phosphorylation;Physiologic intraventricular pressure;Physiological;Physiology;porcine model;pre-clinical;pressure;prevent;Proteins;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary Vascular Resistance;Pulmonary vessels;Rattus;receptor;Regulation;Right Ventricular Dysfunction;right ventricular failure;Right Ventricular Function;Right ventricular structure;Risk Factors;Rodent;Severities;side effect;Signal Transduction;small molecule;Stat3 protein;Structure;targeted treatment;Testing;Therapeutic;therapeutic target;trafficking;translational approach;Translations;Transmission Electron Microscopy;Vascular Diseases;Ventricular;Western Blotting;Workload

PROJECT_TITLE: GP130 Antagonism in Porcine RV Pressure Overload

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: We propose to connect engineering students’ laboratory work with healthcare and help them give their discoveries the best chance to benefit clinical medicine by immersing them in a major medical center to shadow medical practitioners and participate in clinical research. When engineering students see patients’ suffering, they appreciate the urgency and importance of developing medical technology solutions to healthcare problems; when students watch in person their clinician mentor diagnosing and treating patients, students appreciate the utility of medical technology in medicine; when students see the limitations of the patients and the clinical environment, they develop a perspective on what kinds of technology solutions can be clinically workable; when students participate in clinical research, they appreciate the impact of medical technology.

PI_NAMEs: MIN, ROBERT J;PRINCE, MARTIN R;WANG, YI  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TITLE: Clinical Summer Immersion for Biomedical Engineering PhD Students


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE The objective of this proposal is to develop new methods for asthma risk prediction in a health plan setting by incorporating social and financial hardship data, temporal features, and machine learning. Applications of this research will directly enable U.S. health plans to better identify adults and children for enrollment in asthma care management programs in order to moderate their combined clinical and social risks for poor asthma quality. This career development award will support Dr. Alon Peltz, a physician health services researcher, in developing expertise in machine learning risk prediction incorporating expanded social data.

PI_NAMEs: PELTZ, ALON  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Adult;Asthma;asthma exacerbation;Award;care seeking;Child;Classification;Clinical;clinical risk;Computer Models;Continuity of Patient Care;cost;Data;Data Set;Demographic Factors;Development;Early identification;Emergency department visit;Enrollment;Environment;Environmental Risk Factor;Evidence based intervention;experience;Family;Financial Hardship;food insecurity;Future;Goals;Health Insurance;health plan;health record;Health Services;Healthcare;high risk;housing instability;improved;Incentives;Individual;Intervention;Investments;K-Series Research Career Programs;Learning;Link;Low income;Machine Learning;machine learning model;Managed Care;Managed Care Programs;Measures;Mediating;Medicaid;medical schools;medication compliance;Medicine;Mentors;Methods;Modality;Modeling;Morbidity - disease rate;network models;Outcome;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Physicians;Population;Positioning Attribute;predictive modeling;prevent;Privatization;programs;Public Policy;random forest;relative cost;Research;Research Personnel;Resources;Risk;Risk Factors;risk prediction;risk prediction model;screening;Severity of illness;skills;social;socioeconomic disparity;Socioeconomic Factors;Surveys;Time;Uninsured Medical Expense

PROJECT_TITLE: Sociomarkers to Predict Asthma Control and Emergency Room Visits (SPACER)

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE The rapid rise in untreated substance use among justice-involved young (JIY) women in low- and middle- income countries (LMIC) is a critical global public health issue and there is a pressing need to study implementation factors that hinder delivery of substance use services. Integrating substance use and mental health services is a potential efficient and sustainable means of closing the substance use treatment gap for JIY women, but there is limited research on how to effectively implement integrated services in LMIC. The current study leverages quantitative and qualitative methods to study multi-level implementation factors influencing integration of an evidence-based substance use intervention with existing mental health services for JIY women in Brazil, with the goal of informing best practices for services integration in LMIC and resource- constrained, high-income country settings.

PI_NAMEs: RAMAIYA, MEGAN  (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;adolescent substance use;Age;associated symptom;Behavior;Brazil;Child Abuse;Cognitive Therapy;Communities;community collaboration;contingency management;Country;Criminal Justice;Data;detention center;Development;Educational Curriculum;Educational workshop;evidence base;Family;Fracture;Funding;Future;General Population;global environment;global health;Goals;Health Services Research;Healthcare;Healthcare Systems;high risk behavior;high risk population;implementation determinants;implementation science;implementation strategy;Imprisonment;Income;Individual;Interpersonal Violence;Intervention;Justice;low and middle-income countries;Maintenance;male;Mental disorders;Mental Health;Mental Health Services;Mentorship;Methods;mortality risk;National Institute of Drug Abuse;non-suicidal self injury;novel;Politics;Population;Provider;provider-level barriers;Psychiatric Diagnosis;psychiatric symptom;Public Health;Qualitative Methods;recidivism;reduced substance use;Relapse;Research;Research Training;Resources;Risk;service delivery;service providers;Services;social stigma;substance use;Substance Use Disorder;substance use treatment;Suicide attempt;System;theories;Training;Trauma;trauma exposure;Violence;young adult;young woman;Youth

PROJECT_TITLE: Integration of substance use and mental health services for justice-involved young women in Brazil

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Clinical Research;Prevention;Women's Health Research

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE By analyzing tissue samples from benign breast biopsies, we have found that more than 40% of postmenopausal women have incomplete lobular involution, and that these women are at substantially greater risk for subsequently developing cancer. Our project will provide insight into the previously unstudied mechanisms that control lobular involution and will define why postmenopausal women who have not completed the process of lobular involution are at greater risk for breast cancer development. This research will be crucial for better guiding women who obtain breast biopsies toward the most appropriate strategies of surveillance, risk management, and treatment, and will also point towards new physiologic strategies to reduce breast cancer incidence, including the induction of lobular involution in postmenopausal women for whom this process is incomplete.

PI_NAMEs: DEGNIM, AMY C;RADISKY, DEREK C (contact);SHERMAN, MARK E

PROJECT_TERMS: Abbreviations;Address;Affect;African American Women;Age;age related;Aging;Benign;benign state;Biological;Biological Markers;biomarker identification;Biopsy;Black race;Breast;Breast biopsy;Breast Cancer Prevention;Breast Cancer Risk Factor;Breast Diseases;Breast Epithelial Cells;cancer risk;case control;Caucasians;Cell Separation;Cells;child bearing;Classification;Clinic;Clinical;cohort;Control Groups;Cytometry;Data;data integration;Development;Epithelial Cells;Epithelium;Evaluation;Experimental Models;experimental study;Future;Goals;high risk;Human;human disease;humanized mouse;Immunohistochemistry;improved;Incidence;innovation;insight;Investigation;Knowledge;Lactation;Link;Lobular;Lobule;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mammary Gland Parenchyma;Mediator;Methods;milk production;Modeling;Molecular;mouse model;Myoepithelial cell;nano-string;novel;Pathway interactions;Patients;Perimenopause;periostin;Phenotype;Physiological;Physiological Processes;Population;Population Heterogeneity;Postmenopause;predictive marker;Prevention;Process;Proliferating;Publishing;Race;Research;Research Design;Risk;Risk Assessment;Risk Management;risk prediction;Signal Pathway;Site;Source;Structure;surveillance strategy;Testing;Time;Tissue Sample;White Women;WNT Signaling Pathway;Woman;women's diagnosis;Work;Xenograft Model

PROJECT_TITLE: Involution-based biomarkers of breast cancer risk

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Diabetes;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE COVID-19 related mitigation efforts and increased social distancing have impeded access to primary care and chronic disease management, especially for medically and socially vulnerable populations. In this study, we will use a mixed-methods approach combining established and novel data sets with qualitative interviews to understand the short- to medium-term secondary health impact of the COVID-19 pandemic. The results of our study will provide crucial information to help determine how we should direct health care resources during national crises and how to rebuild an equitable health system in the post-pandemic period.

PI_NAMEs: KAPLAN, CAMERON MAXWELL (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: access disparities;Address;Adherence;Affect;Age;Ambulatory Care;Behavioral;billing data;care seeking;care systems;Caring;Chronic;Chronic Disease;Clinic;clinical encounter;Contracts;County;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Analyses;Data Set;design;diabetes management;Diabetes Mellitus;Disease Management;Disparity;Disparity population;Equity;ethnic disparity;ethnic minority;Ethnic Origin;Future;Guidelines;Health;health care service utilization;health disparity;health equity;Health Insurance;health management;Health Resources;Health system;Healthcare;Healthcare Systems;high risk;Hospitalization;Hypertension;improved;Income;Individual;insurance claims;Intervention;Interview;Literature;Low income;Low Income Population;Managed Care;Measures;medical vulnerability;Methods;minority patient;Morbidity - disease rate;Municipalities;novel;Outcome;pandemic disease;pandemic impact;pandemic response;patient population;Patients;Patterns of Care;Persons;Pharmacologic Substance;Policies;Policy Maker;Population;post-pandemic;Preventive care;Preventive healthcare;Primary Care;primary care services;Primary Health Care;Provider;Race;racial disparity;racial minority;Recommendation;Reduce health disparities;Renal function;Resources;Risk;safety net;Screening for cancer;severe COVID-19;Social Distance;social vulnerability;Social Work;socioeconomic disadvantage;structural determinants;Time;United States;Vulnerable Populations

PROJECT_TITLE: COVID-19 Mitigation Efforts and Disparities in Access to Routine Preventive Care and Chronic Disease Management


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project narrative Langerhans cell histiocytosis (LCH) is a disease characterized by granulomatous lesions with characteristic clonal CD207+ CD1a+ mononuclear phagocytes (MNP) with activating somatic mutations in MAPK pathway genes. Optimal therapeutic strategies for patients with LCH remain a major unmet need. We therefore propose to define the roles of cell of origin, differentiation of cells harboring activating MAPK pathway mutations, and the impact of target tissue on pathogenesis in order to identify and test novel therapeutic strategies to improve outcomes for patients with LCH.

PI_NAMEs: ALLEN, CARL E;MERAD, MIRIAM  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Address;Adult;Age;Apoptotic;Applications Grants;BCL2L1 gene;Biological Markers;BRAF gene;Budgets;CD34 gene;Cell Aging;Cell Cycle;Cell Differentiation process;Cells;Cessation of life;Characteristics;chemotherapy;Classification;Clinical;clinical phenotype;Disease;Disease Outcome;disease phenotype;Eosinophilic Granuloma;Erdheim-Chester Disease;FRAP1 gene;Functional disorder;Genes;Goals;Granuloma;Hematology;hematopoietic stem cell differentiation;Hematopoietic stem cells;histiocyte;Histology;Human;humanized mouse;Immunodeficient Mouse;improved;improved outcome;Inflammatory;Inflammatory Infiltrate;inhibitor;Interruption;Kinetics;Langerhans cell;Lesion;MAP Kinase Gene;MEKs;mimetics;Molecular;monocyte;Mononuclear;Morbidity - disease rate;mouse model;Mus;Mutate;Mutation;Myelogenous;Neoplasms;novel;novel therapeutic intervention;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;peripheral blood;Phagocytes;Pharmaceutical Preparations;precursor cell;progenitor;programs;progressive neurodegeneration;promoter;relapse patients;Research;response;Risk;Role;secretory protein;senescence;senolytics;Severity of illness;skin lesion;skin organogenesis;Somatic Mutation;standard of care;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Time;Tissues;Transplantation;Treatment Failure

PROJECT_TITLE: Defining Pathogenic Mechanisms and Therapeutic Opportunities for Langerhans Cell Histiocytosis

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: Project Narrative The ongoing HIV endemic and the COVID-19 pandemic have disproportionately affected racial and ethnic minority groups. Increased rates of COVID-19 diagnosis and mortality among people with HIV (PWH) are likely associated with individual and community factors, that if identified, can be targeted to create better intervention strategies. This study will assess the effect of COVID-19 community-level prevention strategies and the impact of COVID-19 vaccine availability in reducing the risk of COVID-19 in PWH and related disparities and identify factors associated with co-occurring high rates of COVID-19 and HIV across communities.

PI_NAMEs: GWANZURA, TENDAI NOMHLE RUMBIDZAI (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Affect;Age disparity;American;Area;Black race;burden of illness;Communities;Community Surveys;community-level factor;comorbidity;County;County Government;COVID-19;COVID-19 diagnosis;COVID-19 disparity;COVID-19 health disparity;COVID-19 impact;COVID-19 incidence;COVID-19 mortality;COVID-19 pandemic;COVID-19 prevention;COVID-19 risk;COVID-19 surveillance;COVID-19 vaccine;Data;Data Set;Death Rate;Diagnosis;Disparity;disparity reduction;doctoral student;Epidemic;Epidemiologic Methods;ethnic disparity;ethnic minority;ethnic minority population;Ethnic Origin;experience;Florida;gender disparity;Goals;Grant;Health;health determinants;Health Disparities Research;health disparity;Health Policy;Hispanic;HIV;HIV diagnosis;HIV/AIDS;hospitalization rates;Incidence;Individual;Inequity;Intervention;Investigation;Knowledge;Lead;Link;Location;Longitudinal trends;Masks;Mentorship;Meta-Analysis;Minority;Minority Groups;Modeling;mortality;mortality risk;multilevel analysis;Neurofibromin 2;New York;Outcome;Persons;Policies;Population Density;Population Study;pre-doctoral;Prevention strategy;Publishing;Race;racial disparity;racial minority;racial minority population;Reporting;Research;Research Methodology;Research Personnel;Resource Allocation;responsible research conduct;Risk;Risk Reduction;SARS-CoV-2 infection;severe COVID-19;skills;social disparities;Social Distance;social health determinants;socioeconomic disadvantage;Statistical Methods;statistics;stay-at-home order;surveillance data;syndemic;System;Training;trend;trend analysis;United States;United States National Institutes of Health;Vaccination;vaccine acceptance;vaccine access;Vulnerable Populations;web site;Writing

PROJECT_TITLE: Identifying individual and community factors associated with high COVID-19 incidence and mortality rates among people with HIV.


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Autism spectrum disorder (ASD) often manifests with cognitive impairments associated with sensory processing defects. The goal of the proposed research is to understand how a major ASD risk gene regulates the formation of brain connections during learning and how changes in sensory processing associated with ASD risk gene mutation contribute to learning related sensorimotor connectivity. The results of this research will increase our understanding of the contribution of impaired sensory processing and altered sensorimotor connectivity related to a major ASD risk gene.

PI_NAMEs: GOLOVIN, RANDALL M. (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Affect;Animals;Area;ASD patient;autism spectrum disorder;autism symptoms;Behavior;Behavioral;behavioral impairment;Brain;Calcium;career;Clinical;Clothing;Code;Cognition;Cognitive;cognitive control;Cognitive deficits;cognitive function;cognitive performance;comorbidity;Data;Defect;Detection;Diagnosis;Disease;Dorsal;Exhibits;experimental study;Fellowship;Foundations;Functional disorder;functional plasticity;Gene Mutation;Genes;Genetic;Genetic Risk;genetic risk factor;Goals;Heterozygote;Human;Image;Impaired cognition;Impairment;Intellectual functioning disability;Laboratory Research;learned behavior;Learning;loss of function;maladaptive behavior;Measures;Mental disorders;Monitor;Motor Cortex;Motor output;mouse model;Mus;Mutation;National Research Service Awards;Neurobiology;Neurodevelopmental Disorder;Neurons;Neurophysiology - biologic function;Neurosciences;Operant Conditioning;Output;Patients;Performance;Phenotype;Population;predictive modeling;Prosencephalon;protein function;Regulation;repetitive behavior;Reporting;Research;response;risk variant;Role;Running;Sensory;sensory cortex;sensory input;sensory stimulus;sensory system;Signal Transduction;Skin;social deficits;stem;Surface;SYNGAP1;System;Tactile;Task Performances;Testing;Texture;therapy development;tool;Touch sensation;Training;Variant;Vibrissae;Work

PROJECT_TITLE: Impact of autism genetic risk on cortical sensorimotor dynamics


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: IOWA CITY

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Training physician scientists in communicative disorders basic, translational and clinical research is essential to enhance our ability to understand basic disease mechanisms and develop novel, effective treatment of communicative disorders.

PI_NAMEs: HANSEN, MARLAN R (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TITLE: Research Training Program in Otolaryngology


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Symptoms of withdrawal from chronic ethanol exposure are well-known triggers for relapse. While evidence suggests that both the rostromedial tegmental nucleus (RMTg) and the lateral habenula (LHb) mediate withdrawal symptoms, prior work has focused on analyses at the level of whole brain region despite the presence of a dense neural connection between the two regions. The proposed project uses circuit-specific approaches to investigate the role of input from the LHb to the RMTg in the mechanisms underlying symptoms of withdrawal.

PI_NAMEs: YANG, HYERIM  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Abstinence;Acute;addiction;Affect;alcohol abuse therapy;alcohol behavior;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohol withdrawal syndrome;Animals;Anxiety;anxiety-like behavior;Attenuated;avoidance behavior;Behavioral;Brain region;career;Cell Nucleus;Cells;Chronic;Clinical;CpG Islands;Data;DNA;DNA Methylation;Electrophysiology (science);Epigenetic Process;epigenetic regulation;Ethanol;experience;experimental study;Fluorescent in Situ Hybridization;Gene Expression;Genes;Genetic;genetic approach;Genetic Transcription;Glutamates;Habenula;Human;Hyperactivity;Hyperalgesia;Hypermethylation;in vivo;Individual;innovation;insight;Lateral;Measures;Mechanics;Mediating;Mental Depression;Methylation;Molecular;mRNA Expression;mu opioid receptors;negative affect;neural;neuroadaptation;neuromechanism;Neurons;Neurosciences;Neurosciences Research;neurotransmission;new therapeutic target;Pain;pain sensitivity;patch clamp;pharmacologic;Pharmacology;Physiological;Plasma;Play;pre-clinical;Predisposition;promoter;Promoter Regions;Publishing;Rattus;receptor;Relapse;Role;Scientist;Signal Transduction;Sleep disturbances;Slice;sobriety;Symptoms;Techniques;Testing;Training;Transcriptional Regulation;Tremor;Withdrawal;Withdrawal Symptom;withdrawal-induced anxiety;Work

PROJECT_TITLE: Role of afferents to the rostromedial tegmental nucleus in symptoms of withdrawal from chronic ethanol exposure


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE We propose to develop 3D bioprinted personalized autologous vaginal tissue constructs consisting of patient- derived vaginal epithelial and smooth muscle cells for surgical reconstruction. We will utilize clinically applicable 3D bioprinting workflow to manufacture patient-specific vaginal tissue constructs for long-term use, adapting to the needs of growing children and adults. This study will explore the potential of utilizing a 3D bioprinting strategy in a clinically relevant surgical animal model and establish a process development and batch record for regulatory approval.

PI_NAMEs: YOO, JAMES J (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Adult;Anatomy;Animal Model;Animals;Autologous;Biocompatible Materials;bioink;Biomanufacturing;biomaterial compatibility;Biomechanics;Biomedical Engineering;bioprinting;Bladder;bone;Cartilage;Cell Density;Cell Separation;Cells;Child;Childhood;Clinical;clinical application;Clinical Trials;clinically relevant;Development;Discipline of obstetrics;Disease;Dryness;Epithelial Cells;Epithelium;Extracellular Matrix;fabrication;female reproductive tract;Goals;Good Manufacturing Process;Gynecologic;Histologic;Implant;innovation;Intestines;Libraries;Malignant Neoplasms;manufacture;Mechanics;neovagina;non-Native;Operative Surgical Procedures;Organ;Pathologic;Pathway interactions;Patient Care;Patients;pediatric patients;Physiological;pre-clinical;Preparation;Procedures;Process;product development;Production;Property;Protocols documentation;quality assurance;Quality Control;reconstruction;Reconstructive Surgical Procedures;Recording of previous events;Regenerative Medicine;Reproducibility;Running;Safety;Series;Skin;Smooth Muscle Myocytes;Standardization;Technology;Testing;Therapeutic;Tissue constructs;Tissue Engineering;tissue reconstruction;Tissues;Trauma;Urethra;Uterus;Vagina;Validation;Work

PROJECT_TITLE: Production of 3D Bioprinted Autologous Vaginal Tissue Constructs for Reconstructive Applications


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE This project is relevant to public health because it explains how the production of dopamine by specific neuron types can control retinal vascular development and homeostasis. This work has implications for human health because vascular diseases of the eye involve dopamine signaling and because it will lay the foundation for new dopamine targeted therapies aimed at preventing retina pathology.

PI_NAMEs: SAMUEL, MELANIE A (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Amacrine Cells;Basic Science;Biology;Blood Vessels;Catecholamines;cell type;Cells;Coupling;Cues;Data;density;Development;Diabetic Retinopathy;Disease;Dopamine;Dopamine Receptor;dopaminergic neuron;DRD1 gene;DRD2 gene;DRD4 gene;Etiology;Experimental Designs;experimental study;Eye diseases;Failure;Feedback;Foundations;Future;gain of function;Genetic;Growth;Health;Homeostasis;Human;Hypoxia;interest;Knowledge;Lead;loss of function;Maintenance;Measures;Mediating;Molecular Target;Myopia;Nanotubes;Neuromodulator;Neurons;neurovascular unit;novel;novel therapeutics;Oxygen;Pathology;Pathway interactions;Pattern;Pericytes;Physiology;prevent;Production;Public Health;Regulation;response;Retina;retina blood vessel structure;Retinal Ganglion Cells;retinal neuron;Role;Signal Transduction;Source;Specific qualifier value;targeted treatment;Testing;vascular abnormality;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;VEGFA gene;vessel regression;Vision;Visual System;Work

PROJECT_TITLE: Dopamine Mediated Control of Retinal Vascular Integrity

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: ROCHESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: NARRATIVE-RELEVANCE Urban adolescents with asthma suffer from substantial morbidity and suboptimal preventive care. This project is expected to have a profound impact on public health because it proposes an innovative and sustainable intervention that uses specialist directed telemedicine and virtual care management, along with school-based DOT, to optimize guideline-based care and improve outcomes for high risk teens with asthma. Should this program prove successful in improving the health of urban teens with moderate to severe persistent asthma, it has the potential to serve as a sustainable model for improved asthma care in this population.

PI_NAMEs: HALTERMAN, JILL S (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Absenteeism;Adherence;Adolescent;age group;Asthma;care outcomes;Caring;Cessation of life;Child;clinical outcome assessment;Communities;comorbidity;Consultations;contextual factors;Control Groups;Counseling;demographics;Development;Directly Observed Therapy;disparity reduction;Drug Prescriptions;Education;Effectiveness;effectiveness evaluation;elementary school;Emergency department visit;Emergency Situation;enhanced care;Ensure;experience;follow-up;functional outcomes;Guideline Adherence;Guidelines;Healthcare;high risk;Hospitalization;Hypersensitivity;implementation intervention;improved;improved outcome;Inflammation;Infrastructure;innovation;Intervention;intervention effect;Low income;Managed Care;Mediator;medication compliance;Minority;Modeling;Morbidity - disease rate;Motivation;motivational enhancement therapy;National Heart, Lung, and Blood Institute;novel;Nurses;optimal treatments;Outcome;Patient Compliance;Patients;Persons;Pharmaceutical Preparations;Population;Prevention;Preventive;Preventive care;Preventive therapy;primary care provider;primary outcome;Process;Process Measure;programs;Provider;provider communication;Public Health;Quality of life;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Regimen;Resources;response;Risk;Sampling;satisfaction;Schools;Self Management;Site;social factors;Specialist;Symptoms;System;Technology;Teenagers;telehealth;Telemedicine;Testing;Time;treatment planning;urban children;Urban Health;virtual healthcare;Visit;Visiting Nurse;Work

PROJECT_TITLE: Telemedicine Enhanced Asthma Management - Uniting Providers for Teens (TEAM-UP for Teens)