NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: COHEN, ANN D. (contact)

PROJECT_TERMS: Acceleration;Address;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;amyloid imaging;Behavioral Symptoms;Binding;Biological Markers;Biological Models;Brain;Brain imaging;Catalogs;Characteristics;Classification;Clinical;Clinical assessments;clinical effect;Clinical Trials;Collaborations;comorbidity;Data;data integrity;Data Set;Databases;demented;Dementia;Development;Diagnostic Imaging;Disease;Early Diagnosis;Early identification;Early treatment;education research;effective therapy;Elderly;Eligibility Determination;Enrollment;Ensure;Environment;Epidemiology;Etiology;Evaluation;Faculty;Foundations;Functional Imaging;Funding;Genetic study;Gifts;Goals;graduate student;gray matter;Guanosine Triphosphate;head-to-head comparison;Image;imaging agent;imaging biomarker;Imaging Device;imaging modality;imaging study;Individual;Inflammation;Lesion;Ligands;Magnetic Resonance Imaging;Measures;Medical Students;Methodology;Methods;molecular imaging;Monitor;MRI Scans;Nerve Degeneration;Neurobehavioral Manifestations;neuroimaging;neuropathology;non-demented;novel;novel therapeutics;Outcome;outreach;Participant;Pathogenesis;Pathologic;Patients;Performance;Positioning Attribute;Positron-Emission Tomography;Postdoctoral Fellow;pre-clinical;Procedures;protective factors;Protein Isoforms;Public Health;quality assurance;radiotracer;Recommendation;Recording of previous events;recruit;Reproducibility;Research;Research Personnel;Risk Factors;Role;Sampling;Science;specific biomarkers;Stream;structural imaging;Structure;Structure of choroid plexus;Symptoms;tau Proteins;Techniques;Technology;tool;Training;Treatment Efficacy;trial readiness;Universities;Update;white matter;Work

PROJECT_TITLE: Neuroimaging Core


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Chronic Fatigue Syndrome (ME/CFS);Chronic Pain;Clinical Research;Immunotherapy;Pain Research

ORG_CITY: WORCESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Narrative This proposal will examine the ME/CFS from the perspective that an aberrant response to an immunological trigger like infection results in a dysregulated immune system that is partially immunosuppressed due to CD8 T cell exhaustion. These studies will identify potential biomarkers and mechanisms driving the immunopathogenesis of ME/CFS leading to future therapies.

PI_NAMEs: SELIN, LIISA KAARINA (contact)

PROGRAM_OFFICER_NAME: BREEN, JOSEPH J

PROJECT_TERMS: Affect;Antigens;Autoantigens;Automobile Driving;Biological Assay;Biological Process;Body System;CD4 Positive T Lymphocytes;CD4/CD8 ratio procedure;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Count;Cells;Cellular Assay;Characteristics;Chronic;Chronic Fatigue Syndrome;Clonal Expansion;cohort;Complex;CTLA4 gene;cytokine;Data;deep sequencing;Disease;Environment;exhaust;exhaustion;Female;FOXP3 gene;Frequencies;Future;Human Herpesvirus 4;IL17 gene;IL9 gene;Immune response;Immune system;Immunologics;immunoregulation;immunosuppressed;Infection;Inflammation;Inflammatory;Interferon alpha;Interleukin-10;male;Metabolism;Microarray Analysis;Myalgia;Patients;Phenotype;Population;potential biomarker;Production;Publishing;receptor;Regulatory T-Lymphocyte;Reporting;response;Severities;Severity of illness;Signal Transduction;Sorting;Surface;Symptoms;T cell response;T-Cell Activation;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Time;tumor;Up-Regulation;Viral;Virus;Virus Diseases

PROJECT_TITLE: Altered T Cell Responses in Myalgic Enchephalomeylitis/Chronic Fatigue Syndrome (ME/CFS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CFS-N(80)S]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BALTIMORE

ORG_DEPT: SURGERY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Primary Dysautonomia (PD) is a condition in which the autonomic nervous system does not function correctly leading to disabling and pervasive disease. To start investigating the pathogenesis of PD, we initiated a large- scale exome sequencing project consisting of an unprecedented pool of patients and identified mutations in voltage-gated sodium channels as clinically relevant. To probe the involvement of these genes in autonomic dysfunction and PD, we will create robust animal models in which therapeutics can be tested, and by doing so, we expect to generate a first glimpse into possible causes of PD.

PI_NAMEs: BOSMANS, FRANK GERT WERNER;BROCK, MALCOLM V (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Ablation;Action Potentials;Adopted;Affect;Amino Acid Substitution;Animal Model;Animals;Arrhythmia;Autonomic Dysfunction;Autonomic nervous system;autosome;Baroreflex;Behavior;behavior test;Biophysics;Cardiac;Cells;Cervical;Chest;Chromosome 9;Chronic;chronic itch;Chronic Orthostatic Intolerance;Circadian Rhythms;Clinical;clinically relevant;Data;Diffuse;Disabling;disabling disease;Disease;disease model;drug testing;Dysautonomias;Electrophysiology (science);Exhibits;exome sequencing;experimental study;Familial Dysautonomia;Family;Family member;Fatigue;generalized anxiety;Genes;Genetic;Hormonal;Human;Hyperhidrosis disorder;Immunologics;Inheritance Patterns;insight;Knowledge;Link;Measures;Membrane;Methods;Microscopy;Modeling;Monitor;mouse model;Movement;Mus;mutant;Mutation;Nature;Nervous System;Neurons;Outcome;patch clamp;Pathogenesis;Patients;Pharmacological Treatment;Phenotype;Play;proband;Pruritus;reduce symptoms;Reporting;RNA Splicing;Role;Running;segregation;sensory stimulus;Severities;Site;Sodium;Sodium Channel;somatosensory;Spinal Ganglia;Stimulus;Sweating;Sympathetic Ganglia;Sympathetic Nervous System;symptomatology;Symptoms;System;Testing;Therapeutic;Time;trafficking;transcription factor;Variant;voltage

PROJECT_TITLE: Sodium channel mutations as a possible cause for primary dysautonomia

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PI_NAMEs: KAMBOH, M. ILYAS (contact)

PROJECT_TERMS: Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid beta-Protein;Ancillary Study;Archives;Biological Assay;Biological Markers;Blood;Blood specimen;blood-based biomarker;case control;Cerebrospinal Fluid;Clinical;Collection;Complex;cost;Country;Data;data management;Dementia;Deposition;Development;DNA;DNA Library;Early Diagnosis;endophenotype;Enzyme-Linked Immunosorbent Assay;Funding;Future;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic Markers;Genetic Polymorphism;Genetic Risk;Genetic study;genome wide association study;Genomics;Genotype;Goals;Grant;Image;Immunoprecipitation;Individual;International;Late Onset Alzheimer Disease;Light;Magnetic Resonance Imaging;mass spectrometer;Mass Spectrum Analysis;Measures;Medical;Medical Device;Methods;Multicenter Trials;Nerve Degeneration;neurofilament;neurofilament protein L;neurogenetics;neuroimaging;Neuronal Injury;neuropathology;novel;Participant;Pathologic;Performance;Phenotype;Pittsburgh Compound-B;Plasma;Play;Positron-Emission Tomography;Publications;Qualifying;Research;research clinical testing;Research Personnel;Research Project Grants;Resources;Risk Marker;RNA;Role;Sample Size;Sampling;Site;Standardization;tau Proteins;Techniques;Testing;Universities;Validation;Variant

PROJECT_TITLE: Biomarker and Neurogenetics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: AIZENSTEIN, HOWARD J (contact)

PROJECT_TERMS: Acceleration;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;apprenticeship;Area;Basic Science;career;career development;Clinical;Clinical Research;Complex;Dementia;Development;Education;education research;Educational Curriculum;Environment;Evaluation;Event;experience;Extramural Activities;Faculty;Fostering;Funding;Future;Future Generations;Goals;Grant;Growth;Infrastructure;innovation;interest;Leadership;leadership development;Manuscripts;Measures;Medical;meetings;Mentors;Mentorship;mid-career faculty;Modeling;Monitor;Neurosciences;Pathway interactions;Patients;peer coaching;Peer Review;Perception;Preparation;preservation;Process;Productivity;programs;recruit;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;Scholars Program;senior faculty;skills;Time;Training;Training and Education;Training Programs;Underrepresented Populations;Universities;uptake;Vision;Work;Writing

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Dementia;Health Services;Heart Disease;Hypertension;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Hypertension prevalence increases with aging and is a leading risk factor for chronic illnesses including dementia, cardiovascular disease, and several cancers, as well as mortality. Angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) are two of the most commonly prescribed antihypertensive medication classes, used by ~40 million US adults, and are often prescribed interchangeably despite different beneficial effects on physiologic abnormalities in hypertension. In this study, we will use national Veterans Health Administration and Kaiser Permanente Southern California data to determine the long-term comparative effects of ARBs versus ACEIs on the risk of dementia, cardiovascular disease, cancer, frailty, and life expectancy accounting for level of illness and quality of life.

PI_NAMEs: BRESS, ADAM P;COHEN, JORDANA B. (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accounting;active comparator;Address;Adult;Affect;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Angiotensin II Receptor;Angiotensin-Converting Enzyme Inhibitors;Anti-Hypertensive Agents;California;Cardiovascular Diseases;Chronic Disease;Clinical;Code;Cognition;Cognitive;comparative;comparative effectiveness analysis;Comprehensive Health Care;Coronary;cost efficient;Data;Data Sources;Dementia;dementia risk;design;Drug Prescriptions;Electronic Health Record;Event;experience;Fibrosis;follow-up;frailty;Goals;Guidelines;Health;Health Benefit;Heart Diseases;Heart failure;Hypertension;improved;Incidence;Individual;Inflammation;interest;Knowledge;Life Expectancy;Long-Term Effects;Longevity;Malignant Neoplasms;medication compliance;Methods;Modernization;modifiable risk;Morbidity - disease rate;mortality;multiple chronic conditions;Myocardial Infarction;Natural Language Processing;Organ;Outcome;Oxidative Stress;patient oriented;patient retention;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacologic;Physiological;Population;population health;Prevalence;prevent;Public Health;Quality of life;Race;Randomized, Controlled Trials;Recommendation;Regimen;Renin-Angiotensin System;Research;revascularization;Risk Factors;Safety;sex;Socioeconomic Status;Stroke;Subgroup;Time;treatment adherence;treatment effect;vasoconstriction;Veterans;Veterans Health Administration

PROJECT_TITLE: Informing optimal first-line antihypertensive therapy: A rigorous comparative effectiveness analysis of ARBs vs. ACEIs on long-term risk of dementia, cancer, heart disease, and quality of life

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Current theories dichotomize decision-making into planning and procedural information processing, but newer theories suggest more complex, hybrid algorithms may exist within mammalian decision-systems. Understanding the information processing within these decision-systems is critical to help recognize and alleviate disorders that arise from imbalances and dysfunctions within those decision-making systems (such as OCD, eating disorders, and drug addiction) and can also help us develop new behavioral “nudges” that can guide behavior.

PI_NAMEs: REDISH, A DAVID (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Algorithms;Behavior;Behavioral;Cells;Cognitive;Complex;Computer Analysis;Consensus;Corpus striatum structure;Data;Decision Making;design;designer receptors exclusively activated by designer drugs;Development;discounting;Disease;Dorsal;driving behavior;Drug Addiction;Eating Disorders;Evaluation;experience;Food;Functional disorder;Future;Goals;Habits;Hippocampus;Hybrids;information processing;Intervention;Left;Medial;Mediating;Memory;Mental disorders;neural;neuroeconomics;neuromechanism;neurophysiology;Outcome;Perception;prediction algorithm;Process;prospective;Psychiatry;Rattus;Rewards;Role;Running;Self-control as a personality trait;Signal Transduction;Sociology;Structure;System;Technology;Testing;theories;Titrations;Work

PROJECT_TITLE: Testing hybrid theories of action-selection

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Pancreatic cancer is the eighth and ninth leading cause of cancer in men and women, respectively in the United States. The therapeutic options for patients with pancreatic cancer have not improved as quickly as other cancers because the main driver mutations are KRAS and GNAS, two GTPases. We propose a research effort to make the first GNAS inhibitor to treat a subset of pancreatic cancer patients that currently have no targeted therapeutic options.

PI_NAMEs: SHOKAT, KEVAN M. (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Adenylate Cyclase;Adopted;Affinity;Binding;Biological Assay;Bypass;Cancer Etiology;cancer type;cell growth;Cell model;Cells;Chemicals;Complex;Crystallization;Cyclic Peptides;Data;driver mutation;Drops;Drug Design;drug discovery;Evaluation;Exhibits;extracellular;G Protein-Coupled Receptor Signaling;gain of function;gain of function mutation;Gases;Generations;Genetic;GNAS gene;Gnas protein;GTP Binding;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Proteins;Guanosine Triphosphate Phosphohydrolases;Heterotrimeric G Protein Subunit;Human;Hydrogen Bonding;improved;in vitro Assay;inhibitor;kinase inhibitor;KRAS2 gene;KRASG12D;Laboratories;Lead;Learning;Lesion;Ligands;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;MEKs;men;Messenger RNA;Methods;Modeling;Molecular;Molecular Conformation;mouse model;Mucinous Neoplasm;mutant;Mutate;Mutation;novel therapeutics;Nucleotides;Oncogenic;Oncoproteins;Pancreas;pancreatic cancer cells;pancreatic cancer patients;pancreatic neoplasm;pancreatic tumorigenesis;Papillary;Pathway interactions;Penetration;Peptide Library;peptide natural products;Peptides;Permeability;protein complex;Proteins;Recurrence;Research;Resolution;Roentgen Rays;Signal Transduction;Signaling Protein;Specificity;Stimulus;Structure;System;targeted treatment;Technology;Testing;Therapeutic;three dimensional structure;TP53 gene;tumor;Tumor-Derived;United States;Validation;Variant;Woman

PROJECT_TITLE: Inhibitors of the G protein GNAS which drives pancreatic tumorigenesis

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE - UNIVERSITY OF NORTH CAROLINA-CHAPEL HILL, FROHLICH The proposed research is relevant to public health since it investigates the causal role of oscillatory dynamics in cognition with emphasis on output-gating of information and the mechanistic implementation of gating processes in the brain. This work will contribute to a mechanistic understanding of how network-level neural dynamics facilitate cognition across scales, providing new network targets for psychiatric disorders with cognitive impairment, making it highly relevant to the NIH mission of fostering innovative research strategies to improve human health.

PI_NAMEs: FROHLICH, FLAVIO  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Address;Agreement;Attention;Behavior;Behavioral;Brain;brain dysfunction;Clinical;Cognition;cognitive control;Cognitive deficits;cognitive function;cognitive process;Cues;Data;density;Development;Electroencephalography;Electrophysiology (science);Epilepsy;Ferrets;Fostering;Foundations;Frequencies;Future;Health;Human;Impaired cognition;Implanted Electrodes;improved;Individual;information processing;innovation;Intervention;Investigation;Location;Magnetism;Maps;Mediating;Memory;Mental disorders;Mission;neural;Neuroanatomy;Neurons;neurotransmission;noninvasive brain stimulation;North Carolina;novel therapeutic intervention;optogenetics;Outcome;Output;Parietal;Parietal Lobe;Participant;Patients;Pattern;Periodicity;Play;Prefrontal Cortex;Process;Proxy;Public Health;recruit;Research;Resolution;Resources;restoration;Role;Short-Term Memory;Signal Transduction;Site;Source;Task Performances;Testing;Transcranial magnetic stimulation;Translating;treatment strategy;United States National Institutes of Health;Universities;Visual attention;Work

PROJECT_TITLE: Causal investigation of the functional interactions of theta and alpha neural oscillations in output-gating


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Current treatment decisions for millions of patients rely on classification of patients into risk categories using a single model for predicting 10-year risk of cardiovascular events. Although this model and other recently published models have comparable overall performance, their performance varies in racial and other important subgroups. We propose instead of focusing on a single model, develop a consensus of models that best performs in clinically-important subgroups, accommodates availability of known risk factors or missing data patterns to personalize risk estimates.

PI_NAMEs: DEMLER, OLGA  (contact)

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Address;Affect;Algorithms;Area;Biological Markers;Black Box;Boston;Calibration;cardiovascular risk factor;Categories;Classification;Clinical;clinical application;clinical practice;clinical prognostic;cohort;Consensus;Counseling;Data;Data Set;Decision Making;Development;Diagnostic;Discrimination;Electronic Health Record;Ensure;Equation;Equilibrium;Evaluation;Event;explainable machine learning;flexibility;follow-up;Foundations;Future;Goals;gradient boosting;Guidelines;hazard;Healthcare;Hospitals;improved;Individual;Logistic Regressions;machine learning method;Measures;Methods;Modeling;novel;novel marker;patient subsets;Patients;Pattern;Performance;personalized medicine;Population;predictive modeling;prognostic;prognostic model;Property;Prospective cohort;Public Health;Publications;Publishing;Race;Risk;Risk Assessment;Risk Estimate;Risk Factors;risk prediction;risk prediction model;ROC Curve;Subgroup;Techniques;Testing;Time;tool;treatment guidelines;Women's Health

PROJECT_TITLE: Consensus Framework for Cardiovascular Risk Prediction in a Clinical Setting

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: Project Narrative  Nearly half of the U.S. population sometimes or always experiences loneliness, which is alarming given that loneliness confers risk for negative mental and physical health outcomes. Extensive research suggests loneliness is characterized by subjective isolation: many lonely individuals maintain a number of relationships but still report feeling lonely. The goal of this proposal is to use functional magnetic resonance imaging to reveal how the brain represents our subjective connection to and isolation from other people, which will ultimately inform optimal ways to intervene to reduce loneliness.

PI_NAMEs: MEYER, MEGHAN LEIGH (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Acquaintances;Attenuated;Brain;Brain region;Categories;Cognitive;cognitive process;Data;design;Development;Dimensions;experience;Familiarity;Feeling;Functional Magnetic Resonance Imaging;Goals;Individual Differences;information organization;insight;Intervention;Judgment;Knowledge;Loneliness;lonely individuals;Maps;Measures;Medial;member;Mental Depression;Mental Health;mental representation;mental state;Modeling;neural;neurobiological mechanism;Neurobiology;Neurocognitive;Neurosciences;novel;Outcome;Participant;Pattern;Personality;Persons;physical conditioning;Population;Prefrontal Cortex;Process;Reporting;Research;response;Risk;Role;Route;Sampling;self esteem;self organization;social;social cognition;Social Network;Specificity;Statistical Methods;Testing;Training;trait

PROJECT_TITLE: Using the Brain to Reveal Mental Representations of Subjective Connection


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Mental Health;Mental Illness;Neurosciences

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE:  Behavioral and cognitive symptoms of many psychiatric diseases are linked to synaptic loss in the prefrontal cortex. Converging evidence indicates that dynamic neuron-microglia interactions contribute to synaptic deficits in the prefrontal cortex following chronic stress. This application will examine the role of neuron- and microglia- specific molecular mechanisms that initiate synapse loss and resultant behavioral and cognitive impairments.

PI_NAMEs: WOHLEB, ERIC S (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Anhedonia;antagonist;Attenuated;Behavior;Behavior assessment;Behavioral;behavioral impairment;Behavioral Symptoms;Brain;Brain region;calmodulin-dependent protein kinase II;cell type;Chronic;Chronic stress;Clinical Research;Cognitive;Cytomegalovirus;depressive behavior;depressive symptoms;Development;DNA Damage;Electrophysiology (science);environmental stressor;Exposure to;Functional disorder;Gene Expression Profiling;gene network;Genetic;Genetic Transcription;Glucocorticoid Receptor;glucocorticoid-induced orphan receptor;Glucocorticoids;Glutamate Receptor;hippocampal pyramidal neuron;Impaired cognition;Impairment;Induced Neurons;Infusion procedures;insight;knock-down;Link;Macrophage;Macrophage Colony-Stimulating Factor;Major Depressive Disorder;Medial;Mediating;Mediator;Memory impairment;Mental disorders;Microglia;Molecular;Mus;Neurobehavioral Manifestations;Neurobiology;Neuronal Plasticity;Neurons;novel;overexpression;Pathologic;Pathway interactions;pharmacologic;Physiological;Pre-Clinical Model;preclinical study;Predisposition;Prefrontal Cortex;prevent;Proteins;psychosocial stressors;Receptor Signaling;Recombinants;Recurrence;Regulation;Research;response;Reverse Transcriptase Polymerase Chain Reaction;Risk;Role;Self Care;Short-Term Memory;Signal Induction;Signal Transduction;Slice;Sorting;Stress;stress reduction;Synapses;Synaptic plasticity;Synaptosomes;Testing;TNF gene;tool;trafficking;transcriptome sequencing;treatment strategy;Viral;Work

PROJECT_TITLE: Defining neuron- and microglia-specific contributions to prefrontal cortex dysfunction in chronic stress

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Autoimmune Disease;Climate-Related Exposures and Conditions;Genetics;Lupus;Lymphatic Research

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: Narrative Patients with systemic lupus erythematosus and other autoimmune diseases can develop systemic disease flares upon even ambient sunlight, but the mechanisms are poorly understood. Here, we will examine the how the flow of information from skin to immune tissues via lymphatic vessels modulates skin and immune function.

PI_NAMEs: LU, THERESA T. (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Antigen-Presenting Cells;Antigens;Apoptosis;Autoantibodies;Autoimmune Diseases;Autoimmunity;Automobile Driving;B-Lymphocytes;Binding;CCL2 gene;Cell Physiology;Cells;Client;Communication;Data;Development;Disease;draining lymph node;epitranscriptomics;Exposure to;FDA approved;Flare;Gene Expression;Generations;Goals;Human;IFNAR1 gene;IL17 gene;Immune;immune function;Immune response;Immune system;Immunity;Immunize;immunoregulation;improved;in vivo;Inflammation;Inflammatory;Infrastructure;Injury;insight;Intercellular Fluid;Interferons;Interleukin-1;Life Style Modification;Link;Liquid substance;Lupus;lupus-like;Lymph;lymph flow;lymph nodes;Lymphatic;lymphatic circulation;lymphatic dysfunction;Lymphatic function;lymphatic vessel;Lymphoid Tissue;Manual Lymphatic Drainage;Mediating;Mediator;Messenger RNA;Modeling;Modification;monocyte;mouse model;Mus;NADPH Oxidase;Organ;organ injury;Patients;Phenotype;Photosensitivity;Plasmablast;programs;Quality of life;Reactive Oxygen Species;Reader;receptor;Regulation;Regulatory T-Lymphocyte;response;Reticular Cell;RNA;RNA-Binding Proteins;Role;sensor;Shapes;Signal Transduction;Skin;skin disorder;skin lesion;Stimulus;Stromal Cells;Sunlight;systemic autoimmunity;Systemic disease;Systemic Lupus Erythematosus;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;Transcript;Transgenic Model;Transplantation;Ultraviolet Rays;Up-Regulation;UV induced;UV Radiation Exposure

PROJECT_TITLE: Lymphatic regulation of lymph node function in lupus

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: DENVER

ORG_NAME: UNIVERSITY OF DENVER (COLORADO SEMINARY)

ORG_STATE: CO

PHR: NARRATIVE Sexual and gender minority adults face persistent, stark health disparities in both physical and mental health. Romantic relationships are a critical context for understanding health and legalized marriage, an important relationship milestone, is only newly available to sexual minority couples. This project has clear relevance for understanding sexual and gender minority health by examining stress, health, and relationship processes repeatedly and dyadically at multiple levels across the newlywed period among sexual minority couples.

PI_NAMEs: PERRY, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Affective;Alcohol abuse;Alcohol consumption;alpha-amylase;Biological;biopsychosocial;Buffers;Cardiovascular Physiology;cisgender;Climacteric;Couples;critical period;Data;Decision Making;diaries;Diet;Enrollment;Exercise;experience;Exposure to;Face;family support;female couples;Gender;Gender Identity;gender minority health;gender minority health research;gender minority stress;Happiness;Health;Health behavior;Health Benefit;health disparity;health disparity populations;Heterosexuals;high risk;Hydrocortisone;immune function;improved;Individual;Inflammation;Interpersonal Violence;Intervention;Interview;intimate partner violence;Legal;Legal Rights;Lesbian Gay Bisexual;Life;Link;Longevity;longitudinal design;Longitudinal Studies;male couples;marginalization;Marriage;Measures;Mediator;Mental Depression;Mental Health;minority health;minority stress;Morbidity - disease rate;mortality;Motivation;National Institute on Minority Health and Health Disparities;non-heterosexual;Outcome;Pathway interactions;Patient Self-Report;Perception;physical conditioning;Physiological;Physiology;Population;population health;Process;protective factors;Psychopathology;Public Policy;queer;Research;resilience factor;Risk;Risk Factors;Risk Reduction;Sex Orientation;Sexual and Gender Minorities;sexual minority;sexual minority female;sexual minority group;sexual minority health;sexual minority male;sexual minority stress;Shapes;Sleep;social;Social Change;Social Environment;social stigma;social stress;Strategic Planning;Stress;stressor;substance use;Surveys;United States;United States National Institutes of Health;Vision

PROJECT_TITLE: Sexual minority couples' health during the transition to marriage

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Hyperactivation of receptor tyrosine kinase (RTK) signaling is associated with cancer aggressiveness, increased metastasis, and chemotherapy resistance yet direct inhibitors of RTKs have had limited efficacy and a new strategy to target metastatic tumors harboring active RTKs is needed. This proposal will functionally connect RTK-driven changes in metabolism of sphingolipids – bioactive molecules involved in diverse cell processes – to cancer metastasis through the acquisition of anoikis resistance, a key metastasis-enabling biology. These studies will mechanistically advance our understanding of how sphingolipids promote tumorigenesis and establish the sphingolipid enzyme DES1 as a novel therapeutic target for the treatment of metastatic breast cancer harboring hyperactive RTK signaling.

PI_NAMEs: CLARKE, CHRISTOPHER JAMES (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Anoikis;Automobile Driving;Biological;Biological Models;Biology;Breast Cancer Cell;cancer therapy;Carcinoma;Cell Death;Cell Physiology;Cell Survival;cell transformation;Chemoresistance;Circulation;Clinical;Clinical Data;Clinical Trials;CRISPR/Cas technology;Data;desaturase;Development;dihydroceramide;dihydroceramide desaturase;Disease;druggable target;Enzymes;Epidermal Growth Factor Receptor;ERBB2 gene;Extracellular Matrix;Family;gain of function;Generations;glucose uptake;Goals;Hyperactivity;IGF1 gene;IGF1R gene;improved;improved outcome;In Vitro;in vivo;inhibitor;inorganic phosphate;interest;knock-down;Knock-out;lapatinib;Link;Lipids;loss of function;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mediating;Mediator;Metabolism;Metastatic breast cancer;Modeling;mortality;NADP;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutics;Oncogenic;Outcome;overexpression;Pathway interactions;Pentosephosphate Pathway;Phenotype;PIK3CG gene;Probability;Process;Prognosis;Receptor Protein-Tyrosine Kinases;Research Project Grants;Resistance;Role;Signal Transduction;Sphingolipids;Testing;Therapeutic;translational impact;Translations;tumor behavior;tumorigenesis;Tumorigenicity;Tyrosine Kinase Inhibitor;Work;Xenograft Model;Zebrafish

PROJECT_TITLE: Dihydroceramide desaturase (DES1) as a mediator of receptor tyrosine kinase-driven metastasis in breast cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Alzheimer's disease (AD) affects millions of Americans; however, we do not have effective therapies for AD due to lack of understanding of the disease at cellular level. In this project we take the advantage of CRISPR- Cas9 to unlock the molecular role of AD linked protein SORL1, in resident immune cells of the brain. Parallel, we examine the therapeutic potential of SORL1 and its partner proteins using newly developed CRISPR tiling screen strategy.

PI_NAMEs: SHER, FALAK  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Abbreviations;Acceleration;Address;Affect;aging population;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapeutic;Alzheimer's disease therapy;American;Amino Acids;Autopsy;Biology;Brain;brain cell;brain tissue;Cell Adhesion;cell growth;Cell Mobility;cell motility;Cells;Cellular Morphology;Central Nervous System;Chemotaxis;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cognitive function;cohort;Complex;CRISPR/Cas technology;cytokine;Cytokine Receptors;Data;Defect;Dementia;Disease;Disease associated microglia;Disease Progression;Disease susceptibility;Dissection;drug discovery;Drug Targeting;early onset;effective therapy;Epidermal Growth Factor Receptor;Fibronectins;Gene Expression;Genes;Genetic;genetic association;Genetic Predisposition to Disease;genome editing;genome wide association study;Health;Human;Immune;Immunoprecipitation;Impaired cognition;Individual;innovation;Late Onset Alzheimer Disease;link protein;Lipoprotein (a);Lipoprotein Receptor;Macrophage;Mass Spectrum Analysis;Measures;Mediating;member;Memory Loss;Microglia;migration;Molecular;Monitor;Mutagenesis;Mutate;Neurons;novel;novel therapeutics;Open Reading Frames;Pathologic;Phagocytes;Phagocytosis;Phenotype;Play;Prevention;protein complex;Protein Isoforms;protein protein interaction;Proteins;Proteomics;Reaction;receptor expression;Reporting;response;risk variant;Role;Structure;Susceptibility Gene;Technology;Tertiary Protein Structure;Therapeutic;therapeutic target;Tissues;Toxic effect;trait;transcriptome sequencing;Vacuolar Protein Sorting;Western Blotting

PROJECT_TITLE: Functional dissection of fibronectin type 3 domains of SORL1 in Alzheimers disease associated microglia

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: DERMATOLOGY

PHR: Project narrative This proposal seeks to elucidate how human T cells use asymmetric cell division to generate long- and short- lived daughter cells with distinct phenotypes, metabolism and functions. The proposal has broad public health relevance, as the cellular mechanism underlying the development of distinct T cell phenotypes determines the clinical outcome of engineered T cell therapeutics. Similarly, a better mechanistic understanding of persistence of skin-resident T cells has significant implications for inflammatory skin disease pathophysiology and treatment.

PI_NAMEs: ELLEBRECHT, CHRISTOPH THOMAS (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Affect;Bioinformatics;Biology;Blood;career development;Cell division;Cell Separation;Cells;Cellular biology;Cellular immunotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;chronic inflammatory skin;Clinical;Color;Core Facility;Data;Daughter;daughter cell;Dermatology;design;Development;Development Plans;differentiation in vitro;Distal;Effector Cell;effector T cell;engineered T cells;Engineering;Environment;exhaustion;experience;experimental study;fatty acid oxidation;Flow Cytometry;FOXO1A gene;Functional disorder;Funding;Gene Expression Profile;Gene Expression Profiling;Genetic Engineering;genetic manipulation;Genetic Transcription;Germany;Goals;Human;human disease;Human Engineering;human tissue;immunological synapse;Immunotherapy;improved;In Situ;In Vitro;in vivo;Infection;Inflammatory;innovation;Knowledge;Label;Laboratories;Laboratory Research;Longevity;lymphoid organ;Memory;Mentors;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Mitochondria;Mitosis;Molecular;mouse model;Mus;notch protein;novel;Outcome;pathogen;Pathway interactions;Pattern;Pennsylvania;pharmacologic;Phenotype;Physicians;Population;post-doctoral training;pre-clinical;programs;public health relevance;Research;Research Personnel;Residencies;Scientist;self renewing cell;self-renewal;Signal Pathway;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Skin;skin disorder;Skin Tissue;skin xenograft;Structure;T cell differentiation;T cell therapy;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;TCR Activation;Technology;Testing;Therapeutic;tissue resident memory T cell;Tissues;Training;United States National Institutes of Health;Universities;Xenograft Model

PROJECT_TITLE: Asymmetric cell division for fate commitment of human T cells

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Liver Disease;Radiation Oncology

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative We will develop new ultrasound imaging methods to guide and assess liver interventions. The protocols will facilitate visualization of small lesions while avoiding adverse effects such as exposure to ionizing radiation or nephrotoxicity from iodinated contrast material.

PI_NAMEs: FERRARA, KATHERINE W (contact);ZHOU, QIFA

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Abdomen;Ablation;Acceleration;Acoustics;Address;Adult;Adverse effects;Algorithms;Anatomy;angiogenesis;Animals;Biopsy;Blood flow;Buffers;California;Cancerous;Clinical;clinical application;Color;contrast enhanced;contrast enhanced computed tomography;contrast imaging;Contrast Media;cost;Cyst;Dedications;Dependence;design;Diagnosis;Diagnostic Imaging;Dimensions;Disease;Electronics;Elements;Exposure to;Family suidae;Future;Geometry;high resolution imaging;Hospitals;Image;Image Enhancement;image guided;image guided intervention;imaging capabilities;Imaging Device;imaging modality;imaging software;imaging study;imaging system;improved;in vivo;Individual;integrated circuit;Intervention;Intervention Studies;Interventional Imaging;Interventional radiology;Ionizing radiation;Lesion;Liquid substance;Liver;liver ablation;liver imaging;liver visualization;Magnetic Resonance Imaging;Maps;Medical Device;Medical Imaging;Methods;microwave ablation;minimally invasive;Monitor;Needle biopsy procedure;Needles;nephrotoxicity;Noise;novel;Operative Surgical Procedures;Patients;Performance;Physiology;Procedures;Protocols documentation;Radiation;Radiation Dose Unit;Radiology Specialty;Resolution;Resource-limited setting;Scanning;Signal Transduction;Speed;System;Systems Integration;Technology;technology development;technology intervention;technology platform;Testing;three-dimensional visualization;Time;Tissues;tool;Transducers;transmission process;tumor;Ultrasonography;ultrasound;Universities;Update;vector;Vision;Visualization;volunteer;X-Ray Computed Tomography

PROJECT_TITLE: High Resolution Ultrasound in Interventional Radiology

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The modern era of molecular biology has revealed key variants throughout the genome that are enriched in those who develop complex autoimmune diseases, including type 1 diabetes (T1D). Our goal is to understand how these variants in immune checkpoints contribute to a loss of immune tolerance to pancreatic -cells, and toward that objective, this R01 renewal application is centered on CD226, a gene encoding a costimulatory molecule associated with T1D genetic risk and disease development. The results of this project are expected to inform on the biological mechanisms by which CD226 signaling alters peripheral tolerance and contributes toward disease progression, as well as provide preclinical data related to therapeutic targeting the CD226/TIGIT/CD96:CD155/CD112 pathway to correct immune defects and restore immune tolerance.

PI_NAMEs: BRUSKO, TODD MICHAEL (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Transfer;Animals;Antigen-Presenting Cells;Antigens;Antithymoglobulin;Attenuated;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactive T cell;autoreactivity;Beta Cell;Binding;Biological;Biological Assay;Blocking Antibodies;Blood specimen;Candidate Disease Gene;CD3 Antigens;CD8-Positive T-Lymphocytes;cell killing;Cell Lineage;Cell Physiology;Cell Separation;Cells;Chimeric Proteins;Clinical;Code;Complex;conditional knockout;CRISPR/Cas technology;Cytokine Signaling;cytotoxic CD8 T cells;cytotoxicity;Data;Defect;Development;Diabetes Mellitus;diabetes pathogenesis;Diabetes prevention;diabetic;diabetogenic;Disease;Disease Progression;Disease susceptibility;Dose;draining lymph node;drug mechanism;effector T cell;Environmental Risk Factor;experimental study;Female;Flow Cytometry;Frequencies;Gene Expression Profiling;Gene Transfer;Gene Transfer Techniques;Genes;Genetic;Genetic Diseases;Genetic Risk;Genome;genomic locus;Genomics;Genotype;Goals;Grant;Histocompatibility Antigens Class II;Histology;HLA Antigens;Human;human tissue;Image;Immune;immune checkpoint;immune function;Immune mediated destruction;Immune Tolerance;immunoregulation;In Situ;In Vitro;in vivo;in vivo Model;Inbred NOD Mice;Incidence;Individual;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;insulitis;Intervention;Investigation;islet;islet cell antibody;Knock-out;knockout animal;knockout gene;Link;lymph nodes;Lymphocyte;Lymphocyte Function;Methods;Modeling;Modernization;Molecular;Molecular Biology;mouse model;multiple omics;Multiple Sclerosis;Natural History;Non obese;novel;Organ Donor;Pancreas;Pathogenesis;Pathway interactions;Peripheral;peripheral blood;peripheral tolerance;Phase;Phenotype;pre-clinical;prevent;programs;protective allele;Proteins;Proto-Oncogene Proteins c-akt;Publishing;Regulatory T-Lymphocyte;Rheumatoid Arthritis;Risk;risk variant;Role;Safety;Sampling;Signal Transduction;Specificity;Spleen;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;T-Lymphocyte Subsets;targeted agent;targeted treatment;Testing;Th1 Cells;therapeutic candidate;Therapeutic Intervention;therapeutic target;Tissue Donors;Tissue imaging;Tissues;trafficking;transcriptomics;translational potential;Variant

PROJECT_TITLE: The CD226 costimulatory axis in type 1 diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-D(02)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Wound Healing and Care

ORG_CITY: AMHERST

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Current limitations in assessing tissue perfusion around chronic wounds will be addressed through a new imaging modality that combines light and ultrasound. This hybrid technique, called photoacoustic tomography, will allow detailed visualization of tissue perfusion at and around the wound and will facilitate post-surgical wound assessment and treatment.

PI_NAMEs: XIA, JUN  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;absorption;Acoustics;Address;Affect;Agreement;Ambulatory Care Facilities;American;Amputation;Angiography;Ankle;Biometry;Blood;blood perfusion;Blood Vessels;Chronic;chronic ulcer;chronic wound;Circulation;Clinic;Clinical;Clinical and Translational Science Awards;clinical risk;clinical translation;Clinical Trials;Collaborations;computer science;Contrast Media;Control Groups;County;Data;Decision Making;decubitus ulcer;design;Detection;Development;diabetic;diabetic patient;Diffusion;Disease;Doppler Ultrasound;effectiveness analysis;Ensure;Evaluation;feasibility testing;follow-up;foot;Generations;Geometry;Goals;Guidelines;hemodynamics;Hemoglobin;high resolution imaging;Hospitals;Hybrids;Image;image processing;imaging capabilities;imaging modality;imaging platform;imaging system;improved;indexing;innovation;Intervention;Label;Lasers;Leg Ulcer;Light;Lighting;Location;Medical center;Microcirculation;Modality;Monitor;mortality;multidisciplinary;nephrotoxicity;Neuropathy;Operative Surgical Procedures;Optics;optoacoustic tomography;Outcome;Oxygen;Patients;Penetration;Performance;Perfusion;photoacoustic imaging;Photoplethysmography;portability;Positioning Attribute;pressure;prevent;programs;Quality of life;reconstruction;Resolution;revascularization surgery;Rotation;Scheme;Secure;Signal Transduction;Skin;Stasis Ulcer;Surgeon;System;Systems Development;systems research;Techniques;Testing;Three-Dimensional Imaging;Time;Tissue imaging;Tissues;Toes;tool;Transducers;Treatment Cost;treatment group;treatment planning;two-dimensional;Ulcer;ultrasound;United States National Institutes of Health;Universities;Venous;Visit;Visual;Visualization;Work;wound;wound care;wound healing;wound treatment;X-Ray Computed Tomography

PROJECT_TITLE: Development of photoacoustic tomography for non-invasive, label-free imaging of tissue perfusion in chronic wounds

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE STATEMENT The goal of this study is to understand the specific mechansims underlying activation of T cells that already migrated to the tissue and cause inflammatory reactions. We expect to uncover this novel mechanism using molecular and genetic tools, NKD2 and Rab44, that we have identified from large-scale screening efforts. Outcomes of the proposed studies will have positive impact on development of drugs that specifically suppress local inflammatory events (multiple sclerosis, rheumatoid arthritis, psoriasis, etc.) without affecting general immune cell functions.

PI_NAMEs: GWACK, YOUSANG  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Adoptive Transfer;Affect;Animal Model;Autoantigens;Autoimmunity;biochemical tools;Biochemistry;CD28 gene;Cell membrane;cell motility;Cell Physiology;Cells;Central Nervous System;Clinic;Clinical;Cyclosporine;cytokine;Data;Defect;design;drug development;effector T cell;Event;Experimental Autoimmune Encephalomyelitis;FK506;Genetic;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Guanosine Triphosphate Phosphohydrolases;Homologous Gene;Human;IL17 gene;Imaging Device;Imaging Techniques;Immune;immunodeficiency;Immunosuppression;in vivo;Inflammation;Inflammatory;innovation;Interferon Type II;Investigation;Knock-out;Lead;lymph nodes;Mediating;Membrane;Methods;migration;Molecular;Movement;Multiple Sclerosis;Mus;Neurons;NFAT Pathway;novel;nuclear factors of activated T-cells;Outcome;Pathway interactions;PHluorin;Phosphorylation;Physiological;Process;Production;Proteins;Psoriasis;rab GTP-Binding Proteins;Reaction;receptor;Receptor Signaling;Regulation;response;Rheumatoid Arthritis;Role;screening;side effect;Signal Pathway;Signal Transduction;Site;Source;Surface;Symptoms;T cell reconstitution;T cell response;T-Cell Activation;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Th1 Cells;Therapeutic;thymocyte;Tissues;tool;trafficking;Vesicle

PROJECT_TITLE: Mechanism underlying regulation of Ca2+ signaling in local effector T cells

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Digestive Diseases;Lung;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE The coordination between breathing and postinspiratory behaviors such as swallow and laryngeal postinspiratory activity is essential to health and is disrupted in a host of neurological disorders. This project aims to advance the understanding of neurocircuitry governing these complex behaviors, which is currently limited. Novel experimental techniques will be used to elucidate the neural coordination of breathing with the postinspiratory behaviors vital to efficient ventilation and airway protection.

PI_NAMEs: HUFF, ALYSSA  (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: adduct;Anesthesia procedures;Animals;aspirate;Behavior;Behavioral;Brain Stem;Breathing;Cause of Death;Cell Nucleus;Complex;Coughing;Data;Deglutition;Deglutition Disorders;Disease;disorder risk;Dorsal;Electrophysiology (science);expiration;Goals;Health;Implant;in vivo;Individual;Injections;Larynx;Lung;Mus;Nervous System Disorder;neural;neural circuit;Neurologic;Neurons;novel;Obstructive Sleep Apnea;optogenetics;Oral;Patients;Pattern;Periodicity;Phase;Plethysmography;Pneumonia;preBotzinger complex;Preparation;prevent;Property;Respiration;respiratory;Respiratory Center;response;Risk;Role;Techniques;Testing;transmission process;ventilation;vocalization;Water

PROJECT_TITLE: Characterizing the neural circuitry of postinspiratory behaviors and its coordination with breathing


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Pain Research

ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative The TRPM8 ion channel protein has emerged as a promising drug target for diverse diseases including many types of pain; however, we currently understand relatively little about its function at the molecular level. This proposed research sets out to illuminate the mechanisms and networks that underlie TRPM8 function. The outcomes of this research will help us better understand normal human physiology, general fundamentals of membrane protein function, and contribute information that will be helpful in guiding future TRPM8-based drug discovery efforts.

PI_NAMEs: VAN HORN, WADE D. (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Biological Process;Biophysics;cancer type;Cells;Chemicals;cold temperature;Complement;Complex;Computational Technique;Data;Development;Disease;drug discovery;Drug Targeting;Electrophysiology (science);Explosion;Future;Genus Mentha;Goals;Health;Horns;Human;insight;interdisciplinary approach;Ion Channel;Ion Channel Protein;Laboratories;Legal patent;Link;Maps;Membrane Proteins;Menthol;Modernization;Molecular;Obesity;Oncogenes;Outcome;Outcomes Research;Output;Pain;patch clamp;Physiology;prognostic;Property;protein complex;protein function;Proteins;Publications;Regulation;Research;research vision;sensor;Signal Transduction;Stimulus;stoichiometry;structural biology;Structure;Techniques;Therapeutic Intervention;therapeutic target;TRP channel;tumor progression

PROJECT_TITLE: Molecular Mechanisms and Regulation Networks of TRPM8

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Obesity is a common, serious, and costly disease. Fructose consumption is associated with obesity and promotes intestinal villous hypertrophy. This proposal will test how the activity of pyruvate kinase alters the response to dietary fructose and promotes intestinal lipid absorption and obesity.

PI_NAMEs: GONCALVES, MARCUS DASILVA (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: absorption;Address;Adult;Affect;Biochemical;Calories;cancer type;cell motility;Cell Proliferation;Cell Survival;Cessation of life;Chylomicrons;clinical development;combat;Consumption;Cost of Illness;Data;Diet;diet-induced obesity;dietary;Dietary Fats;dietary restriction;Dietary Sucrose;Eating;Energy Metabolism;Enterocytes;Enzymes;Exercise;experimental study;Exposure to;Fatty acid glycerol esters;Feces;Fructose;fructose-1-phosphate;Genetic;Genetic Models;Glucose Intolerance;Goals;Heart Diseases;High Fat Diet;Honey;Human;Hyperinsulinism;Hyperplasia;Hypertrophy;improved;inhibitor;Intervention;intestinal epithelium;Intestines;Isoenzymes;Isotopes;Ketohexokinase;Length;Link;lipid biosynthesis;lipid mediator;lipid metabolism;lipid transport;Lipids;Lipoproteins;Liver;Mass Spectrum Analysis;Measures;Mediator;Metabolic;Metabolism;metabolomics;Modality;Morbid Obesity;Mus;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;nutrient absorption;Obese Mice;obese patients;Obesity;Obesity Epidemic;obesity prevention;obesity risk;obesity treatment;obesogenic;Organoids;pharmacologic;Physical activity;Play;pre-clinical;premature;Prevalence;prevent;Prospective Studies;Protein Isoforms;Pyruvate Kinase;Research;response;Risk;Role;Science;Small Intestines;small molecule;Stroke;Sucrose;sugar;Sweetening Agents;Testing;Time;Tracer;treatment strategy;Triglycerides;uptake;Villous;Villus;Weight Gain;Western World;Wild Type Mouse;Work

PROJECT_TITLE: The role of PKM2 in dietary lipid absorption and fructose-induced obesity

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Alcohol abuse affects millions of people in the United States, and individuals who are resistant to alcohol intoxication and sedation are more likely to develop alcohol use disorder. Chromatin remodeling in GABA neurons is one mechanism that may be involved in alcohol use disorders, because these mechanisms regulate downstream gene expression and neuronal function. I propose to investigate how chromatin in GABA neurons is altered by alcohol abuse, which will elucidate the role of GABA neurons in alcohol use disorder and will identify new therapeutic targets.

PI_NAMEs: MERRILL, COLLIN  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Acute;Affect;Alcohol abuse;alcohol behavior;Alcohol consumption;alcohol effect;alcohol exposure;alcohol measurement;alcohol misuse;alcohol research;alcohol response;alcohol sensitivity;alcohol use disorder;Alcoholic Intoxication;Alcohols;ATAC-seq;Binding Sites;binge drinking;Bioinformatics;Biological Models;Brain;career;Cells;Cessation of life;Chromatin;chromatin remodeling;Chromatin Structure;Consumption;Coupled;Data;Development;Disinhibition;Dose;Drosophila genus;Drosophila melanogaster;Economic Burden;Enzymes;Ethanol;experience;Extramural Activities;fly;Funding;Future;gamma-Aminobutyric Acid;Gene Expression;Gene Expression Regulation;Genes;Genetic;Goals;Grant;high risk;Human;Individual;Insulin Receptor;insulin regulation;Intoxication;knock-down;Knock-out;Mammals;Manuscripts;Mediating;Modeling;Neuronal Plasticity;Neurons;Neurotransmitters;new therapeutic target;Orthologous Gene;Pathway interactions;Persons;Physiology;Play;preference;Principal Investigator;programs;Receptor Signaling;Research;Research Personnel;Resistance;response;Rewards;Risk;Role;Route;Sedation procedure;single cell ATAC-seq;System;therapeutic target;tool;Training;transcription factor;United States;vinegar fly

PROJECT_TITLE: Chromatin remodeling in GABA neurons contributes to alcohol use disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: This project will investigate the strain-dependent tau pathogenesis in Alzheimer's disease (AD) and Frontotemporal Lobar Degeneration with tau pathology (FTLD-tau) using spreading models of tauopathy. The study aims to elucidate the molecular mechanism by which diverse tau strains transmit through the interconnected neurons and compromise neuron functions. Upon  accomplishing the study, we will open up potential avenues for the selective treatment of the diseases via targeting the vital transmission steps of tau pathology.

PI_NAMEs: LEE, VIRGINIA M (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease patient;Amyloid beta-Protein;Argyrophilic Grain Disease;Binding;Biochemical;Biology;Brain;Brain Diseases;Cell-Free System;Clinical;comorbidity;connectome;corticobasal degeneration;Cryoelectron Microscopy;Deposition;Disease;Ensure;Experimental Models;Frontotemporal Lobar Degenerations;Genes;Genetic Predisposition to Disease;genetic risk factor;Goals;Histologic;Human;human model;Impairment;imprint;In Vitro;in vivo;Injections;innovation;insight;Knockout Mice;Lesion;Microtubule-Associated Proteins;Microtubules;Modeling;Molecular;Molecular Conformation;mouse model;Mus;Nerve Degeneration;Neuroanatomy;Neurodegenerative Disorders;Neuroglia;Neurons;neuropathology;novel;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pattern;Pick Disease of the Brain;pre-formed fibril;Procedures;Process;Progressive Supranuclear Palsy;Property;Protein Isoforms;Proteins;Recombinants;Research;Risk Factors;risk variant;Role;Senile Plaques;spatiotemporal;Susceptibility Gene;tau aggregation;tau mutation;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutic development;therapeutic target;tool;Toxic effect;Transgenic Mice;transmission process;Transportation;uptake;Wild Type Mouse

PROJECT_TITLE: Pathogenesis of Tauopathies

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Genetics;Prevention

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Failures in the evolutionarily conserved cell division of meiosis result in infertility and birth defects such as Down syndrome. Proper meiotic segregation requires double strand break repair—a process also required to maintain genome integrity and prevent cancer. This grant seeks to understand the molecular basis for proper chromosome behavior during meiosis. This knowledge may ultimately lead to the diagnosis and/or prevention of certain types of infertility and birth defects.

PI_NAMEs: HOLLINGSWORTH, NANCY M. (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Base Pair Mismatch;Behavior;Biochemical;Biological;Biological Models;Cell Cycle;Cell division;Cells;Chromosome Pairing;Chromosome Segregation;Chromosomes;cohesion;Congenital Abnormality;Diagnosis;Diploid Cells;Diploidy;DNA;DNA biosynthesis;DNA Sequence;Double Strand Break Repair;Down's Syndrome;egg;Ensure;Failure;Family;Fertilization;gene function;Genes;Genetic;Genetic Recombination;genome integrity;Germ Cells;Grant;Haploidy;helicase;Homologous Gene;Human;Hybrids;in vivo;Infertility;Invaded;Knowledge;Life;Malignant Neoplasms;Mammals;Mediating;Meiosis;Meiotic Recombination;member;Mitotic;Mitotic Recombination;Molecular;Mutation;novel;novel strategies;Organism;Orthologous Gene;Phosphorylation;Phosphotransferases;prevent;Prevention;Process;recombinase;Regulation;Research;RNA;Role;Saccharomyces cerevisiae;Saccharomycetales;segregation;Sexual Reproduction;Sister Chromatid;Sorting;sperm cell;Testing;tool;Work;Yeasts

PROJECT_TITLE: Meiotic recombination in budding yeast

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Proinflammatory Th17 and microglial cells have been implicated in Alzheimer’s disease (AD). However, the understanding of their roles in neuroinflammation that drive the AD pathogenesis is limited. In this study we will investigate the mechanisms underlying the regulation of peripheral Th17 and central microglial cells in AD development and progression, as well as the therapeutic potential of pharmacological inhibition of the production of proinflammatory Th17 and microglial cytokines as new immunomodulation therapy for AD.

PI_NAMEs: CAI, DONGMING ;ZHOU, MING-MING  (contact)

PROJECT_TERMS: abeta accumulation;Address;Affect;Age Months;aging related disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease test;Alzheimer's disease therapy;Alzheimer's neuropathogenesis;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Apolipoprotein E;apolipoprotein E-4;Autopsy;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;brain tissue;Bromodomain;CD4 Positive T Lymphocytes;Cells;Central Nervous System;Chemicals;Clinical Trials;Cognitive deficits;cytokine;Dementia;Development;Disease;drug development;Drug Kinetics;drug testing;Etiology;Experimental Autoimmune Encephalomyelitis;Feedback;Female;Genetic Transcription;Genotype;healthy aging;Human;IL17 gene;IL18 gene;Immunomodulators;immunomodulatory therapies;immunoregulation;Impairment;in vivo;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;inhibitor;interest;interleukin-21;interleukin-22;interleukin-23;Interleukin-6;Knock-in Mouse;Lead;male;Mediating;Medical;Microglia;mild cognitive impairment;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;normal aging;novel therapeutic intervention;Oxidative Stress Induction;Pathogenesis;Pathogenicity;Pathologic;Peptides;Peripheral;peripheral blood;Persons;Pharmaceutical Chemistry;pharmacologic;Phenotype;Prevention;Process;Production;Proteins;Regulation;Research;Research Priority;Role;Senile Plaques;sex;Specific qualifier value;Structure;Therapeutic;transcription factor;Transcriptional Regulation;Treatment Efficacy;Up-Regulation;Work

PROJECT_TITLE: Transcriptional Control of Neuroinflammation in Alzheimer's Disease


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: The proposed research will result in technologies that enable the easy nanoscale imaging of biological specimens, such as cells and tissues. These technologies will open up the ability to map how biomolecules are organized in healthy and disease states, enabling discovery of new therapeutic targets.

PI_NAMEs: BOYDEN, EDWARD S. (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Binding;Biological;Biological Preservation;biological systems;Biology;Brain Mapping;cell type;Cells;cellular imaging;Cellular Structures;Chemicals;cold temperature;Communities;Complex;Consumption;Cryoelectron Microscopy;Democracy;Development;Diamond;Disease;Educational workshop;Electron Microscopy;Equipment;Fluorescent Probes;Free Radicals;Goals;Grant;High temperature of physical object;Human;human tissue;Hydrogels;Image;imaging modality;insight;Internet;invention;Label;Lipids;Maps;Medical;Methods;Microscope;Microscopy;nanoimaging;nanoscale;new therapeutic target;Nucleic Acids;Paper;Paraffin Embedding;Persons;Polymers;preservation;Printing;Process;Proteins;Protocols documentation;Reagent;Research;Resolution;Resource Sharing;RNA;Sampling;scale up;Shapes;skills;Specimen;Specimen Handling;Speed;superresolution microscopy;Swelling;Technology;technology development;Time;Tissues;Training;ultra high resolution;Visualization;Water;Work

PROJECT_TITLE: Expansion Microscopy

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE (RELEVANCE STATEMENT) Central to the etiology of the “Great Obstetric Syndromes” (early pregnancy loss, preeclampsia, intrauterine growth restriction, placentae abruptio, and pre-term birth) is the maldevelopment of the uterine-placental interface. Construction of the uterine-placental interface depends on its constituents, including the interplay between invasive trophoblast cells arising from extraembryonic lineages and uterine cells of maternal origin. Identification of regulators of the uterine-placental interface will permit: i) the effective discovery of diagnostics for early detection of failures in placentation; and ii) elucidation of molecular mechanisms controlling placentation that can be targeted for therapeutic intervention.

PI_NAMEs: SOARES, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Abruptio Placentae;Cell Communication;Cell Lineage;Cells;Chromatin;Development;Developmental Process;Diagnostic;Disease;Early Diagnosis;early pregnancy loss;Embryo;Endothelial Cells;Environment;Etiology;Event;Failure;Fetal Growth Retardation;Functional disorder;genetic manipulation;genome-wide analysis;Goals;Health;Human;Immune;Infiltration;Invaded;loss of function;Modeling;Molecular;obstetrical syndromes;Pathogenesis;Pathway interactions;Placenta;Placentation;Population;postnatal;Pre-Eclampsia;Pregnancy;pregnancy disorder;Premature Birth;Process;Property;Rattus;Research Project Grants;Role;Site;Smooth Muscle Myocytes;stem cell population;Stromal Cells;targeted treatment;Therapeutic Intervention;transcriptome;trophoblast;trophoblast stem cell;Uterus;Villous

PROJECT_TITLE: Trophoblast-Guided Uterine Transformation in the Establishment of Pregnancy

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Cancer

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Loss of cell polarity and uncontrolled proliferation are two universal hallmarks of cancer. We have shown that cell polarity is temporarily dismantled during cell division, and that the same machinery that controls cell division triggers the removal of polarity proteins from the cell surface. Building on these discoveries, we will decipher the mechanisms that erase and restore cell polarity when cells divide and determine the consequences to tissue architecture when these processes go awry.

PI_NAMEs: DEVENPORT, DANELLE N (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Adhesives;Architecture;Behavior;Binding;Carcinoma;cell cortex;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell division;Cell Physiology;Cell Polarity;Cell surface;Cell Surface Proteins;Cells;Cellular biology;Complex;Cues;Cytoplasm;Cytoskeleton;defined contribution;Dehydration;Destinations;Disease;Endocytosis;Ensure;epidermis cell;epithelial repair;Epithelium;Excision;Growth;Impairment;in vivo;Inflammatory;Inherited;Injury;insight;Intercellular Junctions;Intracellular Transport;Life;Maintenance;Malignant Neoplasms;Mechanics;Membrane;Memory;Microtubules;Mitosis;Mitotic;Morphogenesis;mouse model;pathogen;Phosphotransferases;planar cell polarity;Positioning Attribute;preservation;Process;Proliferating;Proteins;Recycling;Role;Skin;skin disorder;stem cells;Subcellular structure;superresolution imaging;Surface;Testing;Tissue Preservation;Tissues;trafficking;Tumor Suppression;Vesicle;Work

PROJECT_TITLE: Cell cycle control of cell polarity and fate in epidermal morphogenesis

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Pediatric;Prevention

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: The Child Health Research Career Development Award at Cincinnati Children’s Hospital Medical Center has been in continuous operation for 31 years, fulfilling its mission of training young physician-scientists who are seeking careers in pediatric research. The goal of the program is to provide a strong, well- structured experience that will develop successful and independent investigators in child health who are poised to become leaders in their chosen field.

PI_NAMEs: CHENG, TINA LEE (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Appointment;Area;base;Basic Science;Bioinformatics;career;career development;Child Health;Childhood;Communities;Department chair;Development;diversity and inclusion;Educational Curriculum;Environment;Exposure to;Faculty;faculty mentor;Funding;Future Generations;Gene Expression Regulation;Genetic;Grant;Immunology;innovation;Institution;K-Series Research Career Programs;Medical center;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Nursery Schools;Paper;Pediatric Hospitals;Pediatric Research;Pediatrics;Physicians;Positioning Attribute;Program Development;programs;Publishing;Rare Diseases;Recording of previous events;Research;Research Infrastructure;Scholars Program;Scientist;Series;success;technological innovation;Technology;United States National Institutes of Health

PROJECT_TITLE: Child Health Research Career Development Award (K1-Renewal Yrs 31-35)


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF TORONTO

ORG_STATE: ON

ORG_ZIPCODE: M5S 1S8

PHR: Project Narrative Invasive fungal infections pose an escalating threat to human health and have enormous economic consequences. This project will optimize compounds that inhibit a newly discovered antifungal target to deliver one or more advanced leads for future development of a clinical drug candidate. In doing so, it will pioneer protein kinases as a greatly needed new target class for highly effective single-agent antifungals which also possess the potential for use in resistance- aversive combination regimens, a treatment strategy that has been missing for antifungals but has proven key to controlling other life-threatening infectious diseases.

PI_NAMEs: COWEN, LEAH ELIZABETH (contact);WILLSON, TIMOTHY M

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Acceleration;Achievement;analog;Animals;anti-fungal agents;Antifungal Therapy;Biochemical;Biological Assay;Biology;blood-brain barrier permeabilization;cancer therapy;Candida albicans;Candida auris;casein kinase I;Cell Culture Techniques;Cells;Chemicals;Chemistry;Clinical;Collaborations;Communicable Diseases;Complex;design;Development;Disease;Dose;drug candidate;drug development;Drug Kinetics;Drug resistance;drug resistant pathogen;Drug Targeting;echinocandin resistance;Economics;efficacy evaluation;emerging pathogen;experience;Family;Future;Genetic;Genetic Induction;Genetic Techniques;Genomic approach;Goals;Growth;Health;HIV;Human;Immune;immune function;Immunocompetent;improved;in vitro Assay;in vivo;Industry;Infection;inhibitor;kinase inhibitor;Lead;Life;life span;liver metabolism;Malaria;Malignant Neoplasms;Measures;Medicine;member;Metabolic;Metabolic Diseases;Methods;Molecular Biology;mouse model;multidisciplinary;Mus;Mycoses;Organ Transplantation;Organism;Outcome;pathogen;Pathogenesis;pathogenic fungus;Persons;pharmacologic;Pharmacology;Phosphotransferases;Predisposition;prevent;Property;Protein Kinase;Regimen;Research;Resistance;Resistant candida;Rewards;scaffold;Schedule;Sepsis;structural biology;Structure;Systemic infection;Testing;Therapeutic;Toxic effect;treatment strategy;Tuberculosis;Virulence;Work

PROJECT_TITLE: Targeting the casein kinase 1 (CK1)-like kinase Yck2 in fungal pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-Q(83)]


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Hematopoietic stem cells, which are the source of all blood cells throughout our lifetime, form in the embryo. The goal of this research is to identify important signals that regulate the formation of hematopoietic stem cells in the embryo. The research may ultimately guide the design of new protocols for generating hematopoietic stem cells from other cell sources for use in transplantation.

PI_NAMEs: SPECK, NANCY  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Abbreviations;Adult;Aorta;Arteries;Bar Codes;Blood Cells;Bone Marrow;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;Cell Differentiation process;Cell Maturation;Cell Nucleus;Cell surface;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Confocal Microscopy;Data;Data Set;derepression;design;Development;differential expression;Dorsal;Embryo;Embryonic arterial structure;Endothelial Cells;Endothelium;Family;Generations;Genes;Goals;Gonadal structure;Hematopoiesis;Hematopoietic;hematopoietic stem cell differentiation;hematopoietic stem cell formation;hematopoietic stem cell self-renewal;Hematopoietic stem cells;hemogenic endothelium;Human;human embryonic stem cell;human stem cells;Impairment;in vivo;induced pluripotent stem cell;insight;MADH2 gene;MADH7 gene;Maintenance;Measures;Mesonephric structure;Molecular;Mus;mutant;Mutation;Myelogenous;Pathway interactions;peripheral blood;Population;Production;progenitor;Protocols documentation;receptor;Regenerative Medicine;repaired;Repression;Research;restraint;RUNX1 gene;self-renewal;Signal Pathway;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Smad Proteins;Source;Specific qualifier value;stem cell engraftment;stem cell function;Structure of umbilical artery;transcription factor;transcriptome;Transducers;Transforming Growth Factor beta;Transplantation

PROJECT_TITLE: Repressing TGFbeta family signaling to promote hematopoietic stem cell formation in the embryo

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE HIV infection disproportionately affects rural communities in sub-Saharan Africa, leading to high rates of mortality and fueling ongoing transmission. The proposed research seeks to engage and support rural people living with HIV in Uganda through local traditional healers as an adjunct to routine clinical care, with the goal of improving viral suppression and thereby reducing HIV-associated morbidity and transmission. This proposal aligns with the National Institutes of Health’s mission to foster “innovative research strategies … for ultimately protecting and improving health”, and is responsive to the National Institute of Mental Health’s goal of supporting research to improve the HIV continuum of care in order to reduce HIV deaths and infections worldwide.

PI_NAMEs: SUNDARARAJAN, RADHIKA LU (contact)

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Adult;Affect;Africa;Africa South of the Sahara;African;arm;Benchmarking;Blood;Caring;Cessation of life;Client;Clinic;Clinical;clinical care;Clinical Trials;Cluster randomized trial;Communities;community intervention;Consolidated Framework for Implementation Research;Continuity of Patient Care;Counseling;Data;Death Rate;Dryness;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Enrollment;Epidemic;evidence base;follow-up;Fostering;global health;Goals;Guidelines;Hair;Health;health goals;Healthcare;HIV;HIV Infections;HIV Seropositivity;HIV-1;Human immunodeficiency virus test;Hybrids;implementation determinants;implementation evaluation;implementation outcomes;implementation/effectiveness;improved;Individual;Infection;innovation;Intervention;intervention delivery;Link;Maintenance;Measures;member;men;Methods;Mission;Morbidity - disease rate;Names;National Institute of Mental Health;Newly Diagnosed;novel;Outcome;Participant;Persons;Pilot Projects;primary outcome;programs;Provider;provider intervention;psychosocial;Randomized;randomized, clinical trials;Recommendation;recruit;Reporting;Research;Research Design;Research Support;Resource Allocation;resource guides;Resources;RNA;Rural;Rural Community;Rural Population;secondary outcome;self testing;Service delivery model;Site;Spottings;System;Tenofovir;Test Result;Testing;testing uptake;Training;transmission process;treatment arm;Trust;Uganda;United States National Institutes of Health;uptake;Viral;Viral Load result;World Health Organization

PROJECT_TITLE: Omuyambi: Traditional healer support to improve HIV viral suppression in rural Uganda

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: Project Narrative One of the hallmarks of cancer is its ability to evade the immune system. The immune cells responsible for eliminating tumor cells, known as CD8 T-cells (or informally as “killer” or “effector” T cells), function by entering and destroying tumors. In many cases, however, the CD8 T-cells become “exhausted”, a state in which they infiltrate the tumor normally but fail to kill the tumor cells. The functions of CD8 T cells are controlled by transcription factors that act in the cell nucleus to turn on or repress genes. We previously showed that two distinct classes of transcription factors, NFAT and bZIP proteins, control the balance between CD8 T cell exhaustion and effector function. In this application we will continue our long-term collaboration to investigate the fundamental mechanisms by which these transcription factors influence immune responses against tumors.

PI_NAMEs: HOGAN, PATRICK  (contact);RAO, ANJANA

PROJECT_TERMS: acquired factor;Antibodies;Antigens;Antitumor Response;ATAC-seq;Automobile Driving;Binding;Blocking Antibodies;Calcineurin;Calcium;Calcium Channel;cancer infiltrating T cells;CD19 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Nucleus;Cell Surface Receptors;Cells;Characteristics;chimeric antigen receptor;Chromatin;Chronic;Collaborations;Consensus;Coupled;CTLA4 gene;cytokine;Data;DNA;effective therapy;effector T cell;Engineering;Enhancers;Equilibrium;Evaluation;exhaust;exhaustion;experimental study;Exposure to;Family;Family member;Feedback;follow-up;Functional disorder;Funding;gene repression;Genes;Genetic Transcription;Government;Grant;Human;Immune;immune checkpoint blockade;Immune Evasion;Immune response;Immune system;Individual;Infiltration;inhibitory surface receptor;Lead;Leucine Zippers;Ligands;Lymphocyte;Malignant Neoplasms;Mediating;member;Modeling;Molecular;mouse model;Mus;neoplastic cell;novel;nuclear factors of activated T-cells;Nuclear Receptors;Paper;Patients;Peripheral;Persons;Phenotype;prevent;programmed cell death ligand 1;programmed cell death protein 1;programs;promoter;Proteins;Proteomics;receptor;Repression;response;RNA Splicing;Role;Series;Signal Transduction;Site;Solid Neoplasm;Stromal Cells;success;T-Cell Activation;T-Lymphocyte;Techniques;Testing;transcription factor;Transcription Factor AP-1;tumor;tumor growth;Up-Regulation;Variant;Viral Cancer;Virus Diseases;Work

PROJECT_TITLE: NFAT, bZIP proteins, and transcriptional programs in lymphocytes

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

PI_NAMEs: YAN, DONG  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Age;age related neurodegeneration;aged;Aging;aging mechanism;aging related;Alzheimer's disease patient;animal old age;Animals;anti-microbial peptide;Astrocytes;Caenorhabditis elegans;cell age;Cells;Clinical Research;Data;Development;Disease;driving force;Generations;Genetic;Genetic Screening;Genetic Transcription;Genomics;Goals;Homologous Gene;Host Defense;Human;Immune response;Immune signaling;Infection;Lead;Mammals;Methods;model organism;Modeling;Molecular;Nerve Degeneration;Neurites;Neurodegenerative Disorders;Neuroglia;Neurons;Neuropeptide Receptor;new therapeutic target;novel;Outcome;overexpression;Pathogenesis;Peptide Receptor;Peptide Signal Sequences;Peptides;Play;Population;preservation;prevent;Probability;Protein Biosynthesis;Publishing;Punishment;Rattus;Regulation;Risk Factors;RNA Interference;Rodent;Role;Signal Transduction;Structure;System;tool;Work

PROJECT_TITLE: Use of C. elegans as a model to study aging-associated neurodegeneration


NIH_SPENDING_CATS: Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Relevance to Public Health: The Notch signaling pathway enables cell-cell communication in critical and diverse developmental processes including neurogenesis, somitogenesis, angiogenesis, and hematopoietic development, and is implicated in many diseases, making Notch a major therapeutic target. Using quantitative single-cell analysis of reconstituted signaling pathways together with mathematical modeling, this proposal will provide an understanding of how molecular components of the Notch pathway function together through a newly discovered dynamic ‘code’ that ensures that the correct target gene expression programs are activated in individual cells. These studies will elucidate fundamental mechanisms of Notch function relevant for diverse diseases and pharmacological interventions.

PI_NAMEs: ELOWITZ, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Affect;angiogenesis;Architecture;Behavior;Biological;Biological Models;Brain;Cell Communication;Cell Line;cell type;Cells;cellular imaging;Chick Embryo;Coculture Techniques;Code;Communication;Decision Making;Development;Developmental Process;Disease;Drug Targeting;Drug usage;Engineering;Enhancers;Ensure;Event;experimental study;Family;fringe protein;Gene Expression;Genes;Genetic;Genetic Transcription;glycosyltransferase;Hematopoietic;Image;In Vitro;in vivo;Individual;Intervention;Ligands;Link;Malignant Neoplasms;Maps;mathematical model;Microscopy;Molecular;Monitor;Mus;mutant;nerve stem cell;neurodevelopment;neurogenesis;notch protein;Notch Signaling Pathway;novel;Pathway interactions;Pattern;pharmacologic;Play;predictive modeling;Process;programs;Public Health;receptor;reconstitution;Regenerative Medicine;Regulation;Reporter;Reporting;response;RNA;Role;self-renewal;Signal Pathway;signal processing;Signal Transduction;single cell analysis;single molecule;somitogenesis;Specificity;Spinal Cord;stem cell self renewal;Structure;System;Testing;Therapeutic;therapeutic target;Time;tissue slice preparation;Tissues;Variant;Work

PROJECT_TITLE: Deciphering the Dynamic Notch Signaling Code

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: There are currently no vaccines against any fungal disease. This application is proposes to develop a vaccine for the prevention of Cryptococcosis, a serious and life-threatening disease caused by the fungus Cryptococcus neoformans. Our goal is to take advantage of recent advances to create a novel polysaccharide-protein conjugate that will elicit protective antibody responses and be useful for the prevention and therapy of cryptococcosis.

PI_NAMEs: CASADEVALL, ARTURO  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: anti-fungal agents;Anti-Retroviral Agents;Antibodies;Antibody Response;Antibody-mediated protection;Antigen Targeting;Antigenic Variation;Antigens;antiretroviral therapy;Area;Autoimmune Diseases;Basic Science;Binding;Biochemistry;capsule;Carbohydrates;CD4 Lymphocyte Count;Chemicals;Chronic;Communicable Diseases;Conjugate Vaccines;Cryptococcosis;Cryptococcus;Cryptococcus gattii;Cryptococcus neoformans;Cryptococcus neoformans infection;Defect;design;Development;Diarrhea;Disease;Disputes;Encapsulated;Epitopes;Exhibits;Funding;fungus;Generations;glucuronoxylomannan;Goals;Haemophilus influenzae;Haemophilus influenzae type b;HIV;HIV Infections;Host Defense;Human;human pathogen;Immune;Immune response;immunogenic;immunogenicity;Immunology;Immunosuppression;Incidence;Individual;Infection;Influenza B Virus;interest;Knowledge;Laboratories;Learning;Life;Lymphopenia;Malaria;Malignant Neoplasms;Mediating;Medical;Meningitis;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mus;Mycoses;Natural Source;Neisseria meningitidis;novel;novel strategies;Oligosaccharides;Organ Transplantation;Organic Chemistry;pathogen;pathogenic fungus;pathogenic microbe;Patients;Pharmaceutical Preparations;Polysaccharides;prevent;Prevention;Proteins;Recurrence;Research;response;Risk;Serotyping;Streptococcus pneumoniae;Structure;success;Target Populations;Tetanus Toxoid;Time;Tuberculosis;United States National Institutes of Health;vaccine access;vaccine candidate;Vaccine Design;vaccine development;Vaccines;Virulence;Visit

PROJECT_TITLE: Conjugate vaccines for prevention and treatment of cryptococcosis

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Autosomal Dominant Leukodystrophy (ADLD) is an adult onset disease which leads to CNS degeneration resulting in muscle wasting, weakness and early death for which there is no treatment. We propose to characterize a novel mouse model where we can reduce the levels of the causative protein, lamin B1, to determine whether it can delay or reverse the disease phenotype.

PI_NAMEs: PADIATH, QUASAR S (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Adult;Age of Onset;age related;Antisense Oligonucleotides;Applications Grants;Architecture;Autonomic Dysfunction;autosome;Behavioral;Biochemical;Cessation of life;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CNS degeneration;Data;Demyelinating Diseases;Demyelinations;Development;Disease;disease model;disease phenotype;Disease Progression;DNA cassette;Down-Regulation;Effectiveness;Enterobacteria phage P1 Cre recombinase;Eukaryotic Cell;Excision;Exhibits;experimental study;Gene Expression;Genes;Human;in vivo;Injections;insight;Lamin B1;leukodystrophy;Life;LMNB1 gene;LoxP-flanked allele;Modality;Molecular;motor disorder;motor symptom;mouse model;Mus;Muscular Atrophy;novel;Nuclear;Nuclear Inner Membrane;Nuclear Lamina;Oligodendroglia;Onset of illness;overexpression;Pathologic;Pathology;Patients;Phenotype;Positioning Attribute;pre-clinical;Pre-Clinical Model;prevent;Process;promoter;protein expression;Proteins;RNA Interference;Side;Site;Spinal Cord;Symptoms;Tamoxifen;targeted treatment;Testing;Therapeutic;Time;Transgenic Mice;Transgenic Organisms

PROJECT_TITLE: Modulating Lamin B1 levels  as a therapeutic strategy for Autosomal Dominant Leukodystrophy

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Brain Disorders;Infectious Diseases;Neurosciences;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: SHREVEPORT

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: The proposed project is relevant to public heath because its performance will demonstrate the undefined contribution of RIPK3 to severe human encephalitis disease pathology induced by Herpes Simplex Virus (HSV) infection. Its performance could lead to new therapeutic approaches by targeting RIPK3 signaling therapeutically towards diagnosing, preventing, and/or treating this life-threatening virus-induced encephalitis in human settings.

PI_NAMEs: GUO, HONGYAN  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: adaptive immune response;Apoptosis;Apoptotic;attenuation;Brain;C57BL/6 Mouse;CASP8 gene;Cell Death;Cell Separation;Cells;Central Nervous System;Cessation of life;chemokine;Collaborations;Complex;cytokine;Cytoplasm;Development;Diagnosis;Disease;Double Stranded DNA Virus;Encephalitis;Functional disorder;Herpes encephalitis;Herpes Simplex Infections;Herpesvirus 1;Human;Immune response;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Innate Immune Response;Interleukin-1 beta;Invaded;Knock-in;Knowledge;Left;Life;Literature;Mediating;Mediator;Microglia;Modeling;mortality;mouse model;Mus;Necrosis;neuroinflammation;novel therapeutic intervention;novel therapeutics;Outcome;Pathogenesis;Pathology;Pathway interactions;Performance;Persons;Phosphotransferases;Prevalence;prevent;Production;Public Health;Regulation;Research;RIPK3 gene;Role;scaffold;Signal Transduction;Supporting Cell;Testing;Therapeutic;therapeutic target;Viral;Virus;Virus Diseases;Virus Replication;Western World

PROJECT_TITLE: Role of receptor-interacting serine/threonine-protein kinase 3 (RIPK3) in Herpes Simplex Virus (HSV) Encephalitis

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

PHR: Project Narrative Understanding of the development of anxiety/depression during alcohol withdrawal is critical to the prevention of relapse during alcohol abstinence and overall treatment of alcoholism. This project investigates the effects of adolescent alcohol use on a primary neurotransmitter system (glutamate) in key brain areas (the extended amygdala) known to be important for the development of anxiety/depression. These studies also explore differences in the development of these behaviors between sexes.

PI_NAMEs: WILLS, TIFFANY A (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acute;Adolescence;Adolescent;adolescent alcohol effect;adolescent alcohol exposure;Adult;alcohol abstinence;Alcohol consumption;alcohol exposure;alcohol relapse;alcohol testing;alcohol use disorder;Alcohol withdrawal syndrome;alcoholism therapy;Alcohols;Amygdaloid structure;antagonist;Anxiety;Area;Behavior;Behavioral;behavioral phenotyping;behavioral response;biological adaptation to stress;Brain;Brain region;Cell Nucleus;Data;designer receptors exclusively activated by designer drugs;Development;Electrophysiology (science);experience;Exposure to;Female;foot;Freezing;Future;Genetic;Glutamates;Goals;Hippocampus;Hypothalamic structure;innovation;LoxP-flanked allele;male;Male Adolescents;Mediating;Mental Depression;Modeling;Molecular;mouse model;Mus;negative affect;Neurons;Neurotransmitters;Output;paraventricular nucleus;pharmacologic;Pharmacotherapy;Phenotype;Physiological;presynaptic;prevent;receptor;Recording of previous events;Relapse;relapse prevention;restraint stress;Risk;Risk Factors;Role;sex;Sex Differences;sexual dimorphism;Shock;Signal Transduction;Stress;stressor;Structure;Structure of terminal stria nuclei of preoptic region;Synaptic Transmission;System;Testing;transmission process;underage drinking;Withdrawal;Work

PROJECT_TITLE: Sex Specific Effects of Adolescent Alcohol Exposure on BNST Plasticity

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Precision Medicine;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Patient-derived pluripotent stem cells are essential tools for studying human disease biology and for the development of individualized regenerative medicine, however, stem cells from genetically diverse patients behave in unpredictable ways. One potential route to overcome this confounding variable and help realize the promise of precision medicine is accurate prediction of the diverse cellular states that are dictated by an individual's genome. This project will generate key resources to help achieve this goal by providing experimental tools for the identification and validation of critical genes and pathways governing cell state transitions and differentiation propensity, and the information needed to build predictive models based on an individual's genetic background.

PI_NAMEs: BAKER, CHRISTOPHER LEE;MUNGER, STEVEN CARMEN;REINHOLDT, LAURA G (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acceleration;Adoption;advanced system;Allelic Imbalance;Biological Assay;Biology;Cell Line;Cell Shape;Cell Therapy;cell type;Cells;Chromosome Mapping;cohort;Communities;Confounding Factors (Epidemiology);cost effective;Credentialing;Data;Data Analyses;data integration;Development;directed differentiation;Environment;ES Cell Line;Exhibits;Experimental Designs;gene environment interaction;Gene Expression;Gene Frequency;gene regulatory network;Generations;Genes;Genetic;genetic manipulation;Genetic Research;genetic resource;Genetic study;Genetic Transcription;Genetic Variation;Genome;genomic locus;Genotype;Goals;Grant;Heterogeneity;Human;human disease;human pluripotent stem cell;human stem cells;In Vitro;Inbred Strain;Individual;interactive tool;Laboratory mice;Maps;Masks;Mesoderm;Modeling;molecular phenotype;Mouse Embryonic Stem Cells;Mus;Mutant Strains Mice;novel;Online Systems;Organoids;Pathway interactions;patient derived induced pluripotent stem cells;Patients;personalized medicine;Pharmacogenomics;Phenotype;phenotypic data;Pilot Projects;pluripotency;Pluripotent Stem Cells;Population;precision medicine;predictive modeling;Publishing;Quantitative Trait Loci;rational design;Regenerative Medicine;Reporting;Reproducibility;Research;Resolution;Resources;response;reverse genetics;Role;Route;Sampling;searchable database;single-cell RNA sequencing;SNP genotyping;Source;stem cell biology;stem cells;Structure;System;Systems Development;Testing;The Jackson Laboratory;tool;Toxicogenomics;transcriptome sequencing;Validation;Variant;Visualization software

PROJECT_TITLE: Genetically Diverse Mouse Embryonic Stem Cells: A Platform for Cellular Systems Genetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-P(55)R]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Heme is an essential cofactor, signaling molecule, and metallonutrient that is implicated in the pathogenesis of numerous human diseases. Using an innovative blend of genetic, biophysical, and biochemical approaches, we seek to characterize the molecules and mechanisms underlying heme acquisition, trafficking, and signaling in health and disease.

PI_NAMEs: REDDI, AMIT RAM (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Biochemical;Biodistribution;Biological;Biology;Biophysics;Candida albicans;Cell Line;Cells;Chelating Agents;Chemicals;cofactor;cytotoxic;Disease;Eukaryotic Cell;Gene Deletion;Genetic;Health;Heme;human disease;human pathogen;Image;innovation;Iron;Mammalian Cell;Mediating;Metabolism;Modeling;Molecular Genetics;Mycobacterium tuberculosis;novel;Nutritional;overexpression;pathogen;Pathogenesis;Pathway interactions;Physiology;Process;Proteins;ratiometric;Research;Saccharomyces cerevisiae;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Source;spatiotemporal;Technology;tool;trafficking;transmission process;uptake

PROJECT_TITLE: Illuminating Heme Trafficking and Signaling Pathways in Health and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]