NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Services;Hypertension;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE  This K24 application aims to bolster my dual roles in advancing patient-oriented cardiovascular research and mentorship at Washington University in St. Louis. The research leverages the NHLBI-funded Hypertension Treatment in Nigeria Program, one of Africa's largest hypertension control programs, by focusing on mediation of team-based care and patient retention and re-engagement using advanced implementation science methods. This application also includes a comprehensive, integrated mentorship training approach designed to elevate my capacity, skills, and leadership to support US and international early-stage investigators who will become the next generation’s leaders in global cardiovascular patient-oriented research.

PI_NAMEs: HUFFMAN, MARK D (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Adherence;advanced analytics;Advisory Committees;Africa;Area;Award;Behavior;Blood Pressure;blood pressure control;blood pressure reduction;Cardiovascular system;Caring;Chronic Disease;Clinic;Clinical;Collaborations;Community Services;Competence;Complex;Consolidated Framework for Implementation Research;Data;Data Collection;Data Set;design;Diastolic blood pressure;Dissemination and Implementation;dissemination science;Ensure;Ethics;evidence base;experience;experimental study;Female;follow-up;Funding;Future;global health;Goals;Grant;Graph;Health care facility;Health Personnel;Health system;Heart;Hypertension;hypertension control;hypertension treatment;implementation context;implementation evaluation;implementation research;implementation science;implementation strategy;improved;Individual;infancy;informant;International;Interruption;Interview;knowledge translation;Leadership;Learning;longitudinal analysis;Maintenance;Maps;Measures;Mediation;Mediator;Medical;Mentors;Mentorship;Methods;Modeling;Monitor;National Heart, Lung, and Blood Institute;Nature;next generation;Nigeria;Participant;Pathway interactions;patient oriented;patient oriented research;patient retention;Patients;Pattern;Performance;preference;primary health center;Procedures;programs;psychosocial;recruit;Regression Analysis;Research;Research Personnel;Research Training;Resource-limited setting;responsible research conduct;retention rate;Role;Secure;Series;Site;skill acquisition;skills;success;System;team-based care;Time;tool;Training;Training Programs;Translational Research;Treatment Protocols;United States National Institutes of Health;Universities;Variant;Washington;Woman;Work;World Health Organization

PROJECT_TITLE: HEARTLINK: Harnessing Effective Approaches for Research and Training in Global Cardiovascular Dissemination, Implementation, and Knowledge Translation

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (MA)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE Eosinophils are a key type of white blood cell in allergic disease that were historically characterized as only promoting inflammation, but compelling evidence is emerging that eosinophils have a variety of functions in distinct tissue environments. This proposal will research the range of eosinophil functions during allergic disease, which may improve the understanding of how eosinophil-depleting drugs affect human health. This work may substantially expand the role of eosinophils to include resolving allergic inflammation and may inform strategies to bring personalized and predictive medicine to the treatment of allergic, inflammatory, and autoimmune diseases.

PI_NAMEs: DUNN, JULIA LOUISE MALIK (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;Address;Adopted;Affect;Agreement;Allergic;Allergic Disease;Allergic inflammation;Anti-Inflammatory Agents;Apoptosis;Area;Attenuated;Autoimmune;Autoimmune Diseases;Award;Benign;Biology;Biopsy;Cell Cycle;Cell Cycle Proteins;Cell division;Cells;Chromatin;Chromatin Loop;chronic inflammatory disease;Circulation;Clinical;Clinical Immunology;clinically relevant;Coculture Techniques;Creativeness;Cyclin-Dependent Kinases;Cyclins;cytokine;cytotoxic;design;Development;Diagnosis;differential expression;Disease;disease natural history;druggable target;Effector Cell;Enabling Factors;Environment;eosinophil;Eosinophilia;Eosinophilic Esophagitis;eosinophilic inflammation;Epithelial Cells;Epithelium;Event;experience;Fibroblasts;Fibrosis;Gene Expression;gene function;Genetic;Genetic Transcription;Genome;granulocyte;Health;Homeostasis;Human;Human Pathology;Immunoassay;improved;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory milieu;Injury;innovation;interest;Leukocytes;life span;Maintenance;Malignant Neoplasms;Medical Research;Medicine;Metabolic;Mitosis;Molecular;mouse model;Mucous Membrane;National Institute of Allergy and Infectious Disease;new technology;next generation sequencing;Nuclear Structure;Parasites;Pathogenicity;Pathology;Pathway interactions;Patients;personalized medicine;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Positioning Attribute;postmitotic;posttranscriptional;Prevalence;prevent;Problem Solving;Process;Productivity;Proteins;Publishing;reduce symptoms;Regulation;Reporting;Research;Resolution;Resources;response;Role;Signal Transduction;skills;Small Intestines;Structure;success;System;Technology;temporal measurement;Testing;therapeutic target;Time;Tissue Model;Tissues;transcriptome;Translations;Work

PROJECT_TITLE: Spatial and Temporal Resolution of EosinophilSpecialization in Allergic Microenvironments

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-D (M1)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Rural Health;Social Determinants of Health

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative Climate change is the largest public health threats in the 21st century, with rising global temperatures particularly harming the kidneys of individuals in high-heat environments. Bridging data science insights on the link between heatwaves and kidney disease hospitalization with community engagement is crucial for preparing communities to effectively respond to escalating temperatures. By employing the knowledge-to-action framework, this work aims to unite data science and community wisdom, laying the foundation for community-level interventions that mitigate morbidity and mortality stemming from heat-induced kidney issues.

PI_NAMEs: SMITH, DANIEL JACKSON (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Architecture;Area;built environment;career;Categories;Chronic Disease;Chronic Kidney Failure;Cities;climate change;Clinical Data;Color;Communities;Community Actions;community based participatory research;community engagement;Community Health Education;community intervention;community partnership;community-level factor;Compensation;Complex;Cost Control;Data;Data Science;Data Set;Dehydration;demographics;density;Development;Disease;Environment;Environmental Health;environmental health disparity;Etiology;Evaluation;experience;Foundations;Future;geographic difference;Geography;global temperature;Global Warming;Goals;Green space;Health;Health Care Costs;health disparity;health equity;heat island;Heat Stress;Heat Waves;Height;High temperature of physical object;Home;Hospital Records;Hospitalization;hospitalization rates;Human;Human body;Humidity;Incidence;indexing;Individual;Infarction;innovation;Inpatients;insight;Insurance;Intervention;intervention refinement;Interview;Intestines;Ischemic Stroke;Kidney;Kidney Diseases;kidney dysfunction;Knowledge;land use;Link;Literature;marginalization;marginalized population;Mentored Research Scientist Development Award;meteorological data;Methodology;Morbidity - disease rate;mortality;Neighborhoods;Patients;Pattern;Pennsylvania;Persons;Philadelphia;Population Density;Process;Public Health;Renal function;renal ischemia;Research;Risk;Role;rural area;Secondary to;skills;stem;Surface;systemic inflammatory response;Temperature;Testing;theories;therapy development;Time Series Analysis;tool;Training;Translating;urban area;Urban Hospitals;Work

PROJECT_TITLE: High Heat and Human Health: The Impacts of Heatwaves on Kidney Disease and Data Driven Solutions (The 4H Proposal)

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (89)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Once cognitive impairment occurs in an individual with Alzheimer’s disease, it is difficult to modify the devastating disease process. The long-term goal of this project is to develop a non-invasive tool that can visualize and quantify microstructural brain changes during the preclinical stage of Alzheimer’s disease. To this end, Dr. Yuto Uchida will conduct a proof-of-concept study to investigate the feasibility of ultra-high-field quantitative magnetic resonance imaging as a sensitive biomarker for neurodegeneration in preclinical Alzheimer’s disease.

PI_NAMEs: UCHIDA, YUTO  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: age effect;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnostic;Alzheimer’s disease biomarker;Amyloid;Amyloid Proteins;Anisotropy;Area;Autopsy;Biological Markers;Brain;Classification;Clinical;clinical application;Cognition;Cognitive;cognitive function;cohort;Cohort Studies;comparative;Consensus;Consumption;deep learning;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;Economics;entorhinal cortex;experimental study;Fiber;Funding;Future;Goals;Guidelines;Head;Hippocampus;Histologic;Histology;Histopathology;Human;Image;Impaired cognition;in vivo;Individual;Left cerebral hemisphere;Longitudinal Studies;Magnetic Resonance Imaging;Magnetism;Measures;Mentors;Microscopic;millimeter;Modality;Modeling;Morphologic artifacts;MRI Scans;Myelin;National Institute on Aging;Nerve Degeneration;Neuroanatomy;neuroimaging;neuropathology;Participant;Pathogenesis;Pathologic;Pathway interactions;Perforant Pathway;Phase;Physics;pre-clinical;predictive tools;Predisposition;preventive intervention;Process;prodromal Alzheimer's disease;Protocols documentation;Public Health;Quality of life;recruit;Reference Values;Research Personnel;Resolution;Resources;Rotation;Sampling;Scanning;Serum;sex;skills;Societies;Stains;Structure;tau Proteins;Testing;Therapeutic Intervention;Time;tool;tool development;tractography;Translating;United States;United States National Institutes of Health;Universities;Visualization

PROJECT_TITLE: Quantification of microstructures in the entorhinal-hippocampus pathway as a sensitive biomarker for neurodegeneration during the preclinical stage of Alzheimer's disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Opioids are important pain medications, but chronic opioid use in a particular environment can produce tolerance that is associated with that environment. However, when opioids are consumed in a different place, tolerance can be reversed rapidly, which can lead to fatal overdose. This proposal will explore the contributions of brain and spinal circuits to this environmental control of analgesic tolerance to help inform the development of new treatments aimed at decreasing pain and opioid overdose.

PI_NAMEs: PEREZ, RAFAEL E (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: abuse liability;Academic skills;Acute;addiction;Address;Analgesics;Animals;Anterior;Automobile Driving;Behavior;Behavioral;behavioral pharmacology;Brain;Brain region;career;career development;cell type;Cells;Chronic;cingulate cortex;Data;Development;Dorsal;Environment;experimental study;Fiber;Foundations;Genetic;genetic approach;Goals;Immunohistochemistry;in vivo;insight;Knowledge;Laboratories;Laboratory Research;Learning;Mediating;Mentors;Mentorship;Modeling;Molecular;Mus;neural;Neuroanatomy;Neurons;Nociception;novel;Opioid;Opioid Analgesics;opioid overdose;opioid use;opioid use disorder;Optics;optogenetics;Overdose;overdose death;Pain;Pain management;Pathway interactions;Peripheral;Pharmaceutical Preparations;Pharmacology;Phase;Photometry;Physiological;Play;prescription opioid;prevent;Procedures;Process;professor;Regulation;Research Personnel;response;Risk;Role;Scientific Advances and Accomplishments;Signal Transduction;Site;Spinal;Spinal Cord;Technical Expertise;Techniques;Testing;Therapeutic Effect;tool;Tracer;Training;Transgenic Organisms;Viral

PROJECT_TITLE: Role of Anterior Cingulate Cortex Ensemble Regulation of Spinal Cord Excitability in Associative Opioid Analgesic Tolerance.

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Atherosclerosis;Autoimmune Disease;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Kidney Disease;Lupus;Prevention

ORG_CITY: MADISON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Patients with lupus nephritis (LN) frequently suffer from life-threatening clinical atherosclerotic cardiovascular disease (ASCVD) events, that can lead to devastating health consequences, such as stroke, lifelong paralysis, heart failure, and premature mortality; yet ASCVD preventive strategies are underutilized in LN. Therefore, the proposed work will develop two ASCVD preventive interventions: 1) an implementation guide to help clinicians tailor and start ASCVD preventive strategies by individual patient’s risk; 2) a shared decision-making tool to support patients and clinicians in decisions to start lifesaving ASCVD preventive strategies in LN. Finally, a pilot test will be done to examine the effectiveness and adoption of these ASCVD interventions during LN visits to inform a future multisite clinical trial.

PI_NAMEs: GARG, SHIVANI  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Acceleration;Address;Adherence;Adopted;Adoption;Arteriosclerosis;Atherosclerosis;Belief;black patient;Black race;burden of illness;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular disorder therapy;care delivery;Caring;Clinic;Clinical;Clinical Trials;cohort;Communication;conflict resolution;Consensus;cost;Data;Decision Making;design;Diagnosis;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;efficacy testing;Eligibility Determination;empowerment;Ensure;Environment;Equity;Event;evidence base;Face;Feedback;field study;Focus Groups;Foundations;Fright;Future;Goals;Growth;Health;health equity;Heart;Heart failure;high risk;implementation science;improved;improved outcome;Incidence;individual patient;individualized medicine;innovation;Intervention;Kidney;kidney biopsy;Knowledge;Lead;Life;literacy;Literature;Lupus;Lupus Nephritis;Measures;Medicine;Mentors;Methods;mortality;Multi-Institutional Clinical Trial;multidisciplinary;novel;Outcome;outcome disparities;Paralysed;patient engagement;Patient risk;patient-clinician communication;Patients;peer;performance tests;Pharmaceutical Preparations;Physicians;pilot test;Population;preference;Pregnancy;Premature Mortality;Prevention Research;Prevention strategy;Preventive care;preventive intervention;Preventive therapy;promoter;prospective;Public Health;Publishing;Qualitative Methods;Qualitative Research;Race;racial diversity;Recommendation;Research;rheumatologist;Risk;Risk Factors;Risk Management;Risk Marker;Risk Reduction;risk sharing;Safety;Science;Scientist;shared decision making;Site;social;Solid;Stroke;systemic inflammatory response;Teratogens;Testing;tool;Toxic effect;Training;Translational Research;United States National Institutes of Health;Visit;Wisconsin;Woman;Work;young woman

PROJECT_TITLE: Early and Personalized Cardiovascular Disease Preventive Care in Lupus Nephritis (EPiC-LN)

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Palliative Care

PHR: PROJECT NARRATIVE The new therapies for dementia come with trade-offs, this project aims to develop a decision aid (DA) regarding dementia care to support shared decision making. A DA could facilitate higher quality discussions to assure that patients wanting this therapy are fully informed regarding the potential benefits and harms. Using an iterative, user-centered approach with multilevel partner input, we will conduct a needs assessment among patients and clinicians while simultaneously developing and piloting a DA to support patients and families making decisions about medications for dementia.

PI_NAMEs: MATLOCK, DANIEL D (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: acceptability and feasibility;Aducanumab;Age;Alzheimer's Disease;Amyloid;Awareness;Brain;Brain Edema;Brain hemorrhage;Caregivers;Caring;Clinical;clinical effect;Colorado;Complication;Conflict (Psychology);cost;Decision Aid;Decision Making;Dementia;dementia burden;dementia care;Disease;effective therapy;Eligibility Determination;evidence base;expectation;Family;FDA approved;Image;Impaired cognition;improved;Institute of Medicine (U.S.);International;Knowledge;Medical;Medicare;Methods;Needs Assessment;novel therapeutics;older adult;patient oriented;Patient Preferences;Patient-Centered Care;patient-clinician communication;Patients;Persons;Pharmaceutical Preparations;pharmacologic;pilot trial;Population Heterogeneity;Prevalence;programs;Proteins;provider communication;randomized trial;Research;Sampling;satisfaction;Senile Plaques;shared decision making;Standardization;Symptoms;United States;user centered design;Voice

PROJECT_TITLE: Helping Patients, Families, and Clinicians Make Shared Decisions about Therapies for Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: BOSTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Project Narrative. Late talking bilingual children have atypically small vocabularies in both their languages, and it is unclear how they leverage the words they know to build their vocabularies from dual language input. Therefore, the primary objective of this proposal is to examine interactions between dual language input, semantic structure, and word learning in typically developing and late talking bilingual toddlers. Elucidating relationships between these factors is critical to identifying sources of variability in language outcomes and to developing language interventions for bilingual children with language disorders.

PI_NAMEs: CRESPO, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: 2 year old;aged;Animals;Award;Basic Science;Behavior;Behavioral;bilingualism;biomedical data science;career;career development;Categories;Child;Clinical;Clothing;cohort;Communication;Communication impairment;computer science;Data;Development;Disease;Education;Environment;ethnic minority;Exclusion;experience;experimental study;Exposure to;Future;Goals;Growth;health disparity;health inequalities;Home;indexing;Intervention;Language;Language Delays;Language Development;Language Disorders;language impairment;language outcome;Learning;Link;Measures;Mediating;Mentors;Methodology;Methods;Modeling;National Institute on Deafness and Other Communication Disorders;network models;Neurodevelopmental Disorder;novel;Outcome;Parent-Child Relations;Parents;peer;Performance;Play;Process;Property;Psycholinguistics;Psychology;Public Health;racial minority;Reporting;Research;Resolution;Risk Factors;Sampling;Science;Scientist;Semantics;skills;Source;Spanish;Spanish/English;Speech;standardize measure;statistical learning;statistics;Structure;Testing;theories;Toddler;Toy;Training;visual tracking;Vocabulary;word learning;Work

PROJECT_TITLE: Dual language input, semantic structure and word learning in typically developing and late talking bilingual children

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE. Our proposal addresses a large longitudinal data base on young patients with juvenile-onset depression (JOD), which reflects JOD’s course and outcome from childhood until young adulthood, followed under the auspices of 4 NIMH-funded projects, all of which are in the process of being archived in NIMH’s National Data Archives (NDA). Our aim is to develop prototype machine learning algorithms (which can be customized as needed) to facilitate the analyses of these longitudinal data, with a focus on predictors of clinical and functional outcomes of JOD. Our project will yield developmentally based findings about outcome predictors that can inform the prevention and treatment of JOD, a. particularly severe depression phenotype, and may also shift current analytic practices in developmental psychopathology research.

PI_NAMEs: KOVACS, MARIA  (contact);WEHBE, LEILA

PROGRAM_OFFICER_NAME: KIM, EUNYOUNG

PROJECT_TERMS: Address;Adolescent;Adult;Age;aged;Algorithms;archive data;archived data;Archives;Area;Biological;Childhood;Clinical;clinical predictors;Code;cohort;Communities;Competence;Complex;course development;Data;Data Analyses;data archive;data repository;Data Set;Databases;Depressed mood;Depressive disorder;Development;Diagnosis;Dimensions;Disease;diverse data;DSM-IV;Education;emotion regulation;Emotional;Enrollment;Functional impairment;functional outcomes;Funding;Future;Goals;Grant;Grouping;Hungary;Impairment;Individual;interest;Investigation;Knowledge;large datasets;learning strategy;Life;life span;Literature;longitudinal analysis;longitudinal dataset;Machine Learning;machine learning algorithm;Malignant - descriptor;Mental Depression;Mental disorders;Modeling;National Institute of Mental Health;Nature;novel;novel strategies;Onset of illness;open source;Outcome;outcome prediction;Paper;Participant;Pathway interactions;Patients;Phenotype;pre-trained transformer;prevent;Prevention;proband;Process;programs;prototype;Psychiatric Hospitals;Psychopathology;Pythons;Recurrence;recurrent depression;repository;Research;Research Personnel;research study;Risk;Sample Size;Sampling;Series;sex;Siblings;Sorting;Structure;suicidal behavior;Suicide attempt;Testing;young adult

PROJECT_TITLE: The promise of machine learning for novel approaches to archived developmental data

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ORG_CITY: ALBANY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: PROJECT NARRATIVE This proposal will define the molecules at the axon-Schwann cell interface in aged peripheral nervous system and will provide a core foundation for future in vivo investigations related to the failure of peripheral nerve regeneration and remyelination in the aging humans.

PI_NAMEs: BELIN, SOPHIE  (contact);POITELON, YANNICK

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: ADGR1 gene;Affect;age effect;age related;age related decline;aged;Aging;aging population;Axon;axon injury;axon regeneration;Biological Assay;Cell Communication;cell dedifferentiation;Cell membrane;Cells;Clinical;Communities;Complex;Crush Injury;CSPG4 gene;Data Set;Defect;Demyelinations;design;Development;disabling symptom;Economic Burden;Event;Failure;fall risk;Foundations;Future;Genetic Transcription;Goals;Human;human old age (65+);Impairment;In Vitro;in vivo;Individual;Inherited;Investigation;Investments;Membrane;Methods;Molecular;Molecular Profiling;mouse model;Mus;Mutation;myelination;Natural regeneration;Nerve;Nerve Crush;Nerve Regeneration;nerve repair;Nervous System;Neuroglia;Neurons;Neurosciences Research;neurotransmission;normal aging;old mice;Older Population;Pain;Pathway interactions;peripheral nerve regeneration;Peripheral Nervous System;Peripheral Nervous System Diseases;Phenotype;Porosity;programs;prohibitin;Property;Protein Family;Proteins;Proteome;Proteomics;Quality of life;Recovery;regenerative;Regenerative capacity;remyelination;repaired;response;Schwann Cells;screening;Signal Pathway;Stimulus;Sumoylation Pathway;Support System;Suspensions;System;Techniques;Toxin;traumatic event;United States National Institutes of Health

PROJECT_TITLE: Studying axo-glial interface in aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-M (03)]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Childhood Obesity;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Obesity;Pediatric;Prevention

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative This proposal aims to create a series of new statistical methods to help us better utilize genetic scores in the study of the causes behind intricate human diseases. It will incorporate multi-omics data to facilitate molecularly- informed disease pathways and assess the impact of each pathway on the disease, and also use family-based studies to provide unbiased investigations of how multiple correlated environmental factors or biomarkers influence diseases. It will further provide easy-to-use software tools and a summary statistics database for researchers to analyze large-scale multi-modal data to accelerate future research, enabling a more comprehensive and unbiased understanding of how molecular changes contribute to human diseases.

PI_NAMEs: WANG, ZIQIAO  (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Acceleration;Address;autism spectrum disorder;Award;Biological Markers;Body fat;Body mass index;Cardiovascular Diseases;career development;Child;Childhood;Chronic Disease;clinical application;Cognitive;cohort;Collaborations;Communication;Complex;Computing Methodologies;Conceptions;Coronary Arteriosclerosis;Data;Data Set;Data Sources;Databases;Development;Disease;Disease Outcome;Disease Pathway;disease phenotype;disorder prevention;disorder risk;diverse data;DNA;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Etiology;Family;Gene Expression;Genes;Genetic;genetic association;Genetic Markers;Genetic Research;genome wide association study;Genomics;Goals;Health;high body mass index;Human;human disease;improved;indexing;Individual;Inherited;innovation;insight;Intervention;Investigation;Knowledge;large scale data;Leadership;Link;Machine Learning;machine learning method;Malignant Neoplasms;Mediating;Mental disorders;Mental Health;Mentors;Methodology;Methods;Modeling;Modernization;Molecular;mortality;multi-ethnic;multimodal data;multimodality;Multiomic Data;multiple omics;muscle form;Nature;non-genetic;novel;Obesity;orofacial cleft;Outcome;Parents;Partner in relationship;Pathway interactions;Phase;Phenotype;Polygenic Traits;Population;population stratification;Prevention;programs;Proteins;Public Health;Regulatory Pathway;Research;Research Personnel;Resource Development;Risk;Risk Assessment;Risk Factors;Role;Scoring Method;Series;Single Nucleotide Polymorphism;skills;Software Tools;Source;Statistical Methods;statistics;success;Testing;tool;tool development;Training;trait;Universities;user friendly software;Variant;Work

PROJECT_TITLE: Enhancing the Interpretability and Applicability of Polygenic Scores through Multi-Omics Integration and Analysis of Family-Based Studies

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Disorders in inferring and acting according to context as well as in learning how to behave in new contexts are implicated in numerous neurological disorders, including post-traumatic stress disorder, schizophrenia, and addictive behavior. The neural representations that support reliable contextual behavior are not well-understood, which complicates the development of specific behavioral and pharmacological interventions. This proposal will reveal the neural representations that underlie the learning and performance of contextual behavior.

PI_NAMEs: JOHNSTON, WILLIAM J (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Addictive Behavior;Anatomy;Animals;Area;artificial neural network;Banana;Behavior;Behavioral;Biological Neural Networks;Brain;brain behavior;Brain region;Bread;career;career development;Code;Cognition Disorders;Complex;cost;Data;Decision Making;Development;Dimensions;Disease;Disparate;Eating;Electrophysiology (science);experimental study;Faculty;flexibility;Future;Geometry;Health;high dimensionality;Human;Impairment;indexing;insight;Intervention;learned behavior;Learning;Literature;mathematical theory;Measures;Mediating;Mentors;Mentorship;Mind;Monkeys;Nervous System Disorder;neural;neural network;Neural Network Simulation;Neurons;Neurosciences;nonhuman primate;novel;Performance;Persons;pharmacologic;Phase;Population;Post-Traumatic Stress Disorders;programs;Recording of previous events;Reporting;Research;Resource Development;response;Role;Running;Schizophrenia;Sensory;Series;Shapes;Speed;Stimulus;Structure;System;Techniques;Testing;theories;Training;Universities;Work

PROJECT_TITLE: The Role of Functional Modularity in the Neural Code Underlying Contextual Behavior

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE This project seeks to pilot test the feasibility and acceptability of the PINPOINT intervention (Preventing CervIcal caNcer through HPV self-cOllection and patIent NavigaTion) for women with type 2 diabetes, obesity, and social vulnerability. The overarching objective of this career development award is to support Rahma Mkuu, Ph.D., MPH’s career development into an independent implementation scientist addressing cancer disparities.

PI_NAMEs: MKUU, RAHMA S (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: acceptability and feasibility;Address;Applications Grants;Area;Award;biomedical informatics;Biometry;black women;Cancer Center;Cancer Control;cancer diagnosis;cancer health disparity;cancer risk;career development;Caring;Cervical Cancer Screening;Chronic;Chronic Disease;Clinic;Clinical;Clinical Research;Collection;Continuity of Patient Care;Data;Data Set;Death Rate;Development;Diagnosis;Doctor of Philosophy;Educational Status;effectiveness testing;Electronic Health Record;enhanced care;ethnic minority population;Ethnic Origin;Etiology;Evidence based intervention;experience;Florida;Goals;Health;health belief;Health Insurance;Healthcare;high risk;Human Papillomavirus;implementation outcomes;implementation science;implementation strategy;improved;Incidence;Individual;intersectionality;Intervention;intervention mapping;K-Series Research Career Programs;Literature;Low income;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mentored Research Scientist Development Award;Methods;Minority Status;Modeling;mortality;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;patient navigation;Patients;Persons;pilot test;pilot trial;Population;Positioning Attribute;Poverty;prevent;Process;Proctor framework;protective behavior;Protocols documentation;Race;racial disparity;racial minority population;Randomized;Research;Risk;Risk Factors;rural area;rural residence;Sampling;Schedule;Scientist;screening;skills;social disparities;social vulnerability;survivorship;Testing;theories;Time;Training;trial comparing;United States;Vaccination;Woman;World Health

PROJECT_TITLE: Preventing Cervical Cancer through HPV Self-collection and Patient Navigation among Women Living with Chronic Conditions and Social Vulnerability

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The lymphatic system is essential for regulating fluid and maintaining tissue water balance, and its dysfunction can result in significant edema. Commonly used anesthetics may impact the lymphatic system and contribute to dangerous edema in critical illness, but this remains largely unexplored. The goal of this research project is to understand how anesthetic medications interact with the lymphatic system, with the potential to guide safer medication choices and improve patient outcomes in surgeries and intensive care settings.

PI_NAMEs: RUSCIC, KATARINA J (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: absorption;Acute;Address;Adrenergic Agents;Adrenergic alpha-Antagonists;Adrenergic Receptor;Aftercare;Anesthesia procedures;Anesthesiology;Anesthetics;Area;Arterial Lines;Behavior;Biological Assay;Biology;Blood;Blood Plasma Volume;Blood Vessels;Carbon Dioxide;career;Catheters;Cells;Circulation;Clinical;clinical practice;Complement;Confocal Microscopy;Critical Care;Critical Illness;Dangerousness;Dedications;Development;Dexmedetomidine;Doctor of Philosophy;Drainage procedure;Edema;Electrophysiology (science);Environment;Equilibrium;experimental study;Exposure to;Extracellular Fluid;Extravasation;Fatty acid glycerol esters;Fluid Balance;Fluorescence;Functional disorder;Functional Imaging;Future;General Anesthesia;General Hospitals;Goals;Grant;hemodynamics;Hour;Human;imaging modality;Imaging Techniques;Immune;Immunity;improved;in vivo;Inflammation;Infusion procedures;Inhalation;innovation;instrument;Intensive Care;Intensive Care Units;Intercellular Fluid;Intravenous;Intravenous Anesthetics;Isoflurane;K-Series Research Career Programs;Ketamine;Laboratories;Lead;Liquid substance;Literature;Location;Lymph;Lymphangiography;Lymphatic;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic function;lymphatic imaging;lymphatic pump;Lymphatic Research;Lymphatic System;lymphatic vessel;Lymphoid Tissue;Maps;Massachusetts;Measurement;Measures;Mechanical ventilation;Mediating;medical schools;Medicine;Membrane Potentials;Mentors;Mentorship;Metabolic Clearance Rate;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Cells;Norepinephrine;novel;Operating Rooms;Operative Surgical Procedures;patch clamp;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phentolamine;Physiology;Play;Positioning Attribute;prevent;Propofol;Publishing;Receptor Activation;Research;Research Project Grants;Resources;Role;Scientist;Shapes;skill acquisition;skills;Stains;Sympathetic Nervous System;Testing;Time;Tissues;Tracheostomy procedure;Training;translational model;Translational Research;ultra high resolution;Uncertainty;uptake;Venous;ventilation;Water;Work

PROJECT_TITLE: The Impact of Anesthetics on Lymphatic Vessel Contractility and Extracellular Fluid Uptake

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE The skin is our body’s first line of defense from external stressors, such as pathogens or physical injuries. Under normal condition, a tight equilibrium between different cells composing the skin is necessary to avoid inflammatory diseases. This proposal employs a multidisciplinary and innovative approach to elucidate how cooperation between different cells maximizes the ability of the skin to protect us against environmental stressors and tumor formation. These studies may reveal novel and specific targets for treatment of wound healing, inflammatory disorders or cancer.

PI_NAMEs: PARIGI, SARA MARTINA  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: alpha-beta T-Cell Receptor;Anatomy;antimicrobial;Architecture;career development;Cell Communication;Cell Physiology;Cells;chemokine;Data;Development;Disease;Environment;environmental stressor;epidermal stem cell;Epidermis;epithelial stem cell;Epithelium;Equilibrium;Future;Gene Expression;Gene Expression Profile;Gene Silencing;Genetic;Genetic Transcription;Goals;Hair;Hair follicle structure;Heterogeneity;Homeostasis;Immune;Immune system;Immunologist;Immunology;imprint;in utero;in vivo;Inflammatory;Injury;innovation;Knowledge;Label;Laws;Light;Lipids;Lymphocyte;Lymphoid;lymphoid structures;Lymphoid Tissue;lymphotoxin beta receptor;Malignant Neoplasms;Mediating;Mentorship;Modeling;Molecular;mouse model;multidisciplinary;Mus;Names;novel;Oncogenic;Outcome;Output;overexpression;pathogen;Pathway interactions;Pattern;Positioning Attribute;Postdoctoral Fellow;Predisposition;Premature aging syndrome;Proliferating;recruit;Research;Research Personnel;Role;single-cell RNA sequencing;Skin;Specific qualifier value;Specificity;stem cell biology;stem cell fate specification;stem cell niche;stem cells;stemness;stressor;Supervision;System;T-Lymphocyte;Technical Expertise;Technology;tertiary lymphoid organ;Testing;Tissues;tool;tool development;Training;transcriptomics;tumor;Validation;Work;wound healing;wound treatment

PROJECT_TITLE: Exploring immune-mediated stem cell heterogeneity within and across niches


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Prevention;Social Determinants of Health;Suicide

ORG_NAME: HUNTER COLLEGE

PHR: PROJECT NARRATIVE Autistic sexual and gender minority adults are at high risk for co-occurring mental health conditions including depression, anxiety, and suicide attempts and require a psychosocial intervention tailored for their unique needs. This research involves developing and piloting a novel community-based minority stress intervention for autistic sexual and gender minority individuals. The emphasis on preparing for future adaptive interventions and on safe, ethical research with a population at heightened risk for suicide will make significant contributions to the autism research field and will promote the ultimate goal of improved psychosocial functioning and mental health in the autistic community.

PI_NAMEs: GRAHAM HOLMES, LAURA  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: 18 year old;acceptability and feasibility;active control;adaptive intervention;Address;adolescent with autism spectrum disorder;Adopted;Adult;adult with autism spectrum disorder;Advisory Committees;Affect;Anxiety;Anxiety Disorders;Area;Attention;autism spectrum disorder;autistic;biopsychosocial;Bisexual;burden of illness;career development;cisgender;Clinical;clinical implementation;Clinical Trials;Clinical Trials Design;Communication;Communities;community engaged intervention;community engagement process;community organizations;community setting;cost;Data;Data Collection;data management;design;Detection;Development;Diagnostic;Disparity;Distress;Education;emotion dysregulation;Employment;Ethics;evidence base;Evidence based intervention;expectation;experience;Family;feasibility testing;Future;Gays;gender minority;gender minority group;gender nonconforming;General Population;Goals;health disparity;Heterosexuals;high risk;Hybrids;implementation evaluation;implementation measures;implementation research;implementation/effectiveness;improved;Individual;individuals with autism spectrum disorder;innovation;internalized stigma;Intervention;intervention effect;intervention refinement;Interview;Lesbian;Lesbian Gay Bisexual Transgender;Major Depressive Disorder;Measures;member;men;Mental Depression;Mental Health;Mental Health Services;Mentored Patient-Oriented Research Career Development Award;Mentors;Meta-Analysis;Methodology;Minority;minority stress;Modeling;Monitor;Motivation;Neurodevelopmental Disability;novel;peer;Persons;pilot test;pilot trial;Population;Population Intervention;Preparation;Procedures;Process;Protocols documentation;psychoeducational intervention;Psychologist;Psychopathology;psychosocial;public health relevance;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Registries;Reporting;Research;Risk;Risk Factors;Safety;Sampling;satisfaction;Science;Services;Sexual and Gender Minorities;sexual minority;sexual minority group;skills;social;Social isolation;social stigma;Social support;Societies;Speed;stressor;successful intervention;suicidal;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Testing;therapy development;Time;trial design;Underserved Population;United States National Institutes of Health;Woman

PROJECT_TITLE: ALIVE: Development and feasibility of a psychosocial intervention for sexual and gender minority autistic adults

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE This research aims to identify broad-specificity phage-recombination systems that can facilitate straightforward and efficient genome editing across a diverse spectrum of human pathogens. This approach offers an innovative means of pinpointing the genetic determinants of bacterial pathogenicity. By comprehending how a bacterium's genetic makeup determines its capacity to cause disease, we can uncover novel strategies to counteract bacterial threats to human health.

PI_NAMEs: VARBLE, ANDREW  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;Automobile Driving;Bacteria;Bacterial Genome;Bacteriophages;Clinical;clinically relevant;combat;Coupling;Disease;DNA;DNA-Binding Proteins;ds-DNA;Effectiveness;Elements;Escherichia coli;ESKAPE pathogens;Exhibits;experimental study;Genetic;Genetic Determinism;genetic element;Genetic Engineering;genetic information;genetic makeup;genetic manipulation;Genetic Recombination;Genetic Variation;Genome;genome editing;Genome engineering;Genomics;Genus staphylococcus;Goals;Gram-Negative Bacteria;Health;homologous recombination;Human;human pathogen;Immune Evasion;Immune response;Individual;innovation;Integration Host Factors;Laboratories;Libraries;Life Cycle Stages;Mediating;Metagenomics;microbial;microbial genome;novel;novel strategies;Organism;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Play;Process;Proteins;recombinase;Research;Resistance;resistance mechanism;Role;Species Specificity;Specificity;Staphylococcus aureus;Structure;System;Techniques;Virulence;Virulent;Work

PROJECT_TITLE: Harnessing Broad-Specificity Phage Recombinases for Universal Bacterial Editing platforms


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Adoptive T cell therapy (ACT) has had limited success against pancreatic cancer, because of the T-cell intrinsic epigenomic programs and the tumor microenvironment (TME) suppressive factors that limit their anti-tumor functional status. Using single-cell and spatial omics, the proposed research will identify strategies that improve the anti-tumor activities of ACT T cells in TME. The proposed project will clarify the fundamental knowledge of the ACT for pancreatic cancer and will ultimately lead to more effective therapy for pancreatic cancer patients.

PI_NAMEs: SU, YAPENG  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Immunotherapy;Antigens;Architecture;ATAC-seq;Award;Benchmarking;Binding;Biological Assay;Biology;cancer cell;Cancer Center;cancer immunotherapy;cancer therapy;Cell Communication;Cell Physiology;cell type;Cells;cellular engineering;Clinical;Clinical Sciences;Clinical Trials;clinically actionable;clinically relevant;Computational Biology;Computer Analysis;computer framework;CRISPR/Cas technology;Data;Data Set;Death Rate;Dryness;effective therapy;engineered T cells;Engineering;Environment;Environmental Risk Factor;Epigenetic Process;epigenomics;experience;experimental study;Faculty;forging;Functional disorder;functional status;Generations;Genetically Engineered Mouse;Goals;Hematopoietic Neoplasms;high dimensionality;histone modification;Immune;immune checkpoint blockade;Immunocompetent;Immunooncology;immunoregulation;Immunotherapy;improved;in vivo;Infiltration;innovation;Institution;Interleukin-10;Knock-out;Knowledge;laboratory experience;Lead;Ligands;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Measures;Mentors;mesothelin;Molecular;Molecular Profiling;mouse model;multiple omics;Mus;Myeloid-derived suppressor cells;neoplastic cell;novel;overexpression;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patient-Focused Outcomes;Persons;Pharmaceutical Preparations;Phase;Phenotype;Positioning Attribute;Prevention;programs;Reagent;receptor;Refractory;Regulatory T-Lymphocyte;Relapse;Research;Resolution;Resources;RNA;Science;single cell analysis;skills;Solid Neoplasm;success;Systems Biology;T cell response;T cell therapy;T-Lymphocyte;Technology;Testing;therapy resistant;Training;transcription factor;transcriptome;transcriptomics;Transforming Growth Factor beta;Treatment Efficacy;Treatment Failure;Treatment outcome;tumor;tumor growth;tumor microenvironment;United States;Universities;Work

PROJECT_TITLE: Using Single-cell and Spatial Multi-omics to Improve Adoptive Cell Therapy against Pancreatic Cancer

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: NARRATIVE Problem substance use is a significant issue for many contemporary Indigenous communities, both reservation-based and urban, and opioid misuse is especially disproportionate among Indigenous young adults (ages 18-29) throughout the state of Montana, despite the fact that Indigenous communities hold traditional knowledge and tools, including traditional ceremonial practices (TCPs), that could be wielded to stem the tide of problem substance use. By obtaining community guidance on the rigorous adaptation of an existing evidence-based substance abuse prevention intervention to incorporate TCPs we can develop an effective, sustainable, and culturally centered approach aimed at reducing opioid misuse among urban Indigenous young adults. Once obtained, evidence of effectiveness of this approach can be used to more broadly inform public policy and, especially, expand reimbursement for these services by public and private payors to enhance their sustainability.

PI_NAMEs: CHASE-BEGAY, DAMIAN M (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Administrator;Adolescent;Age;Age Years;Alaska Native;Alaska Native population;American Indian Tribe;American Indians;Appointment;Award;Behavior;Behavioral;Behavioral Sciences;California;career development;Cause of Death;Centers for Population Health;Cessation of life;Client satisfaction;Clinic;Clinical;Clinical Trials;Collection;college;Communities;community based participatory research;Community Health;cost;culturally appropriate intervention;Data;design;Doctor of Philosophy;Drug usage;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness testing;effectiveness/implementation trial;Elements;Epidemiologist;Epidemiology;Ethnic Population;European;evidence base;Evidence based practice;experience;Focus Groups;follow-up;Future;Gender Identity;Genocides;Goals;Health;health care settings;health disparity;health organization;Health Promotion;Health Sciences;Healthcare;Heroin;Human;Hybrids;illicit drug use;implementation evaluation;implementation science;implementation strategy;implementation/effectiveness;Indigenous;indigenous community;Individual;informant;Intervention;Interview;invention;Knowledge;Leadership;Master of Science;Measurement;Mental disorders;Mentors;Methods;mid-career faculty;misuse of prescription only drugs;Montana;Native Americans;Native-Born;Neurosciences;Not Hispanic or Latino;Opioid;opioid abuse;opioid misuse;opioid use;Outcome Measure;Participant;peer;Perception;Pharmaceutical Preparations;PhenX Toolkit;Population;post intervention;Postdoctoral Fellow;prescription pain reliever;Prevalence;prevent;preventive intervention;Privatization;Process;professor;programs;Provider;Psychiatry;Public Health;public health intervention;Public Health Schools;Public Policy;Questionnaires;racial population;Reporting;Research;research and development;Research Personnel;reservation-based;Respondent;Risk Factors;San Francisco;satisfaction;School-Age Population;Schools;screening;Services;Sex Orientation;Site;Social Work;Source;stem;Structure;substance abuse prevention;Substance abuse problem;Substance Addiction;substance use;substance use prevention;Surveys;System;Target Populations;Testing;therapy design;tool;Training;Trauma;tribal community;Tribes;United States National Institutes of Health;Universities;urban area;Washington;Work;young adult;Youth

PROJECT_TITLE: Reducing opioid misuse among urban Indigenous young adults in Montana using a culturally centered intervention

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurosciences

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Violation of our predictions about the world impact our affective state and when this happens repeatedly this may lead to increased or decreased moods. By changing the context of prediction violations, I aim to establish the neural mechanisms of mood-like states and to then non-invasively modulate these mechanisms to alter mood- like states. Specifically, by combining neurophysiology with computational modelling and focused ultrasound, this proposal has the unique potential to causally establish single-neuron and population activity associated with mood-like states in primate brain circuits that can be directly translated into novel treatments in the clinics for patients with depression.

PI_NAMEs: FOLLONI, DAVIDE  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Affect;Affective;Amygdaloid structure;Animals;Anterior;Applications Grants;Area;awake;Award;Basic Science;Behavior;behavior influence;Behavioral;Biological Markers;Brain;career;Cephalic;Chronic;cingulate cortex;Clinic;Clinical;Computer Models;Corpus striatum structure;Coupling;Data;density;Depressed mood;depressive symptoms;Development;Disease;dopaminergic neuron;Environment;Expectancy;expectation;experience;experimental study;Focused Ultrasound;Frequencies;frontal lobe;Goals;Grant;Hour;Human;Hyperactivity;Image;improved;insight;Institution;Insula of Reil;interdisciplinary approach;Laboratories;Laboratory Research;Lead;Learning;Limbic System;Location;Macaca;Major Depressive Disorder;medical schools;Mental Depression;Mentors;Midbrain structure;Monkeys;Moods;multidisciplinary;negative affect;neural;neural correlate;neural patterning;Neurobiology;neuromechanism;Neurons;neurophysiology;neuroregulation;next generation;nonhuman primate;noninvasive brain stimulation;novel;Pathologic;Pathway interactions;Patients;Pattern;Persons;Phase;Physiological;Population;Positioning Attribute;Primates;Principal Investigator;Protocols documentation;Recording of previous events;recruit;Regulation;Research;Resolution;Rewards;Role;Scientist;Shapes;Signal Transduction;simulation;Techniques;Testing;Training;Translating;ultrasound;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Neural Mechanisms and Neuromodulation of Affective States

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-M (03)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Amblyopia is the leading cause of preventable vision loss among children in the United States. This project aims to identify vision screening policies that increase screening uptake, examine how factors influence access to eye specialty care, and develop predictive models to identify children with preventable vision loss. The findings will deepen our understanding of the social determinants of vision health in children and inform the development of novel interventions to improve visual outcomes for children nationwide.

PI_NAMEs: OKE, ISDIN  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Acceleration;Address;Adolescence;Affect;Amblyopia;Area;barrier to care;Biometry;Blindness;Boston;care delivery;career;career development;caregiver education;Caring;Characteristics;Child;Childhood;clinical predictive model;cohort;Cohort Studies;community intervention;computer infrastructure;Cross-Sectional Studies;Data;Data Science;Data Scientist;Data Sources;design;Development;Development Plans;Devices;Diagnosis;Diagnostic;Disparity;early childhood;effectiveness evaluation;Electronic Health Record;elementary school;Environment;Ethnic Origin;Evaluation;Eye;fifth grade;Funding;Geographic Distribution;Goals;Health;health care availability;Health Disparities Research;health equity;health equity promotion;Health equity research;Health Services;Health Services Research;high risk;Household;improved;Income;Institution;insurance claims;interest;Intervention;Investigation;kindergarten;Knowledge;Link;machine learning model;marginalized community;Measures;medical schools;medical specialties;Mentorship;Modeling;multilevel analysis;National Eye Institute;Neighborhoods;novel;Nursery Schools;Ophthalmologist;Ophthalmology;Outcome;Pediatric Hospitals;Performance;Policies;Population;predictive modeling;Prevalence;Preventive;Public Health;Race;Reduce health disparities;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk;risk prediction;Sampling;School-Age Population;screening;screening policy;skills;social determinants;social epidemiology;social health determinants;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Source;Specialist;success;Surveys;tool;Training;Training Programs;Treatment Failure;United States;United States National Institutes of Health;Vision;Vision Screening;Visual;Visual impairment

PROJECT_TITLE: Social Determinants of Vision Health in Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (04)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Complementary and Integrative Health;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: PORTLAND

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PORTLAND STATE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Chronic pain unduly burdens Black adults across the lifespan, yet a dearth of studies focus on the pain characteristics, treatment experiences, and support needs of young Black adults. Supporting young Black adults with managing their own pain is key for reducing the impact of pain, but self-management education programs are criticized for cultural incongruence, inattention to the social determinants of health that increase pain in Black adults, and they commonly exclude mind-body therapies that reduce pain and improve psychological comorbidities. The proposed project will culturally and structurally adapt the evidence-based Chronic Pain Self-Management Program (CPSMP) for young Black adults to improve their self-management competency and improve pain outcomes.

PI_NAMEs: WOLF, DE'SHA SHANTRELL (contact)

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: Achievement;Adult;Affect;Age;aged;All of Us Research Program;American;Area;Attention;Attitude;Behavior;behavioral health intervention;Black Populations;Black race;black women;career;career development;Caring;Characteristics;chronic pain;chronic pain management;Clinical;Communities;community advisory board;community based research;community collaboration;comorbidity;Competence;Complementary and alternative medicine;Complex;Data;Decision Making;depressive symptoms;disability;Disparity;disparity reduction;Education;Educational workshop;Effectiveness;Elderly;Enrollment;evidence base;Exclusion;Exhibits;experience;Face;Feasibility Studies;Focus Groups;Frequencies;Future;Goals;Health;implementation science;improved;inattention;inferential statistics;Integrative Medicine;Intervention;intervention mapping;Interview;Knowledge;life span;Massage;Medicine;Mentored Research Scientist Development Award;Mentors;Methods;Mind-Body Intervention;mind/body;mindfulness intervention;Minority;minority children;Modality;Modeling;National Center for Complementary and Integrative Health;Not Hispanic or Latino;Oregon;Outcome;Pain;Pain intensity;Pain interference;Pain management;pain outcome;pain reduction;Pain Research;pain self-management;pain symptom;pain-related disability;Participant;patient oriented;peer;persistent symptom;Play;Population;Positioning Attribute;Practice Management;preference;Prevalence;prevent;Prevention;Process;programs;Protocols documentation;psychologic;Qualitative Research;Quality of life;Questionnaires;Recommendation;Relaxation Techniques;Reporting;Research;Sampling;Science;Scientist;Self Care;Self Efficacy;Self Management;self-management program;Severities;social;social health determinants;structural determinants;Techniques;Training;United States National Institutes of Health;Universities;Yoga;young adult

PROJECT_TITLE: Culturally and Structurally Adapted Chronic Pain Self-Management Program for Young Black Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (05)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Stroke;Telehealth

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Blood pressure control and physical activity in the first months after a stroke are known to reduce the risk of a second stroke and improve recovery, but effective interventions and strategies to promote these factors are lacking, particularly for ethno-racial minorities. We hypothesize that repetitive learning through self-monitoring and motivational feedback with patient-tailored infographics can improve these preventive health behaviors through enhanced self-regulation. Therefore, in alignment with the NINDS mission to reduce the burden of neurological disease for all people, we will develop and test a scalable patient-centered telehealth-delivered behavioral intervention for secondary stroke prevention in our underserved urban population.

PI_NAMEs: NAQVI, IMAMA A (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Adherence;Attention;attentional control;Awareness;Back;behavior change;behavior influence;Behavior Therapy;Behavioral;behavioral outcome;biomedical informatics;Black Populations;Blood Pressure;blood pressure control;blood pressure intervention;blood pressure medication;blood pressure reduction;career;Caring;Cerebrovascular Disorders;Chronic Disease;Clinical;Cognitive;cognitive process;Comprehension;Counseling;critical period;Data;Devices;Diagnosis;disability;disparity reduction;Education;effective intervention;efficacy evaluation;efficacy outcomes;efficacy trial;ethnoracial minority;Event;feasibility trial;Feedback;Focus Groups;functional status;Future;Goals;Health;Health behavior;Health behavior change;Health Disparities Research;health goals;Health Promotion;Hispanic Populations;Home;Hospitals;human centered design;Hypertension;improved;improved outcome;Individual;Inequity;Informal Social Control;Intervention;Intervention Trial;K-Series Research Career Programs;Language;learned behavior;Learning;Limited English Proficiency;Link;low health literacy;Master of Science;Measures;Medical;medication compliance;Mentors;Methods;Minor;Minority;Mission;Modeling;modifiable risk;Monitor;Motivation;motivational enhancement therapy;multidisciplinary;multimodality;multiphase optimization strategy;National Institute of Neurological Disorders and Stroke;Nature;Nervous System Disorder;Neurology;novel;Outcome;patient engagement;patient oriented;patient oriented research;Patient Recruitments;Patients;Persons;Physical activity;Physicians;Population Heterogeneity;post stroke;Prevalence;Prevention Research;Preventive;preventive intervention;Provider;Qualitative Methods;racial diversity;Randomized;real world application;Recovery;Recurrence;Reporting;Research Personnel;Resources;Risk;Risk Factors;Risk Reduction;Self Management;social cognitive theory;Spanish/English;Stroke;stroke event;stroke intervention;stroke outcome;stroke patient;Stroke prevention;stroke recovery;stroke risk;Technology;telehealth;telemonitoring;Testing;theories;Time;tool;Training;Translational Research;Treatment Efficacy;trial design;United States National Institutes of Health;uptake;Urban Population;urban underserved;usability;Visit;wireless;wireless electronic;Work

PROJECT_TITLE: Optimizing telehealth to improve secondary stroke prevention

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: DURHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Signaling pathways are reused in multiple contexts from disease states, to development, to tissue homeostasis. Using a multidisciplinary approach, this proposal will establish how the context and dynamics of BMP signaling lead to the correct cellular outputs at the level of gene expression. The quantitative input- output signaling relationships identified in this study may provide useful information for the use of BMPs as therapeutics or in the use of BMP molecules to promote robust cellular differentiation for regenerative biology applications.

PI_NAMEs: BRANTLEY, SUSANNA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Adult;Animals;Architecture;Award;Biological;Biological Models;Biological Phenomena;Cell Differentiation process;Cell Nucleus;Cells;Characteristics;cohort;Collaborations;combinatorial;Complex;Data;design;Development;Developmental Biology;Disease;Disease Progression;Dorsal;Drosophila genus;EGF gene;Elements;Embryo;embryo tissue;Embryonic Development;Epidermal Growth Factor Receptor;experimental study;Family member;Feedback;Fire - disasters;Flour;fly;Foundations;Future;gastrulation;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Geometry;Goals;Health;Homeostasis;human disease;Image;imaging approach;Imaging Device;Imaging Techniques;In Vitro;in vivo;Insecta;interdisciplinary approach;Knowledge;Laboratories;Lateral;Lead;Maintenance;mathematical model;Measures;Methods;Modeling;Molecular;morphogens;Natural experiment;Natural regeneration;Order Coleoptera;Output;Pathway interactions;Pattern;Phase;Play;Population;predictive modeling;Process;Productivity;programs;promoter;Recording of previous events;regenerative biology;Regulation;Research;response;Role;Running;sensor;Signal Pathway;Signal Transduction;skills;spatiotemporal;Specific qualifier value;Specificity;Speed;Testing;Therapeutic;Time;Tissues;tool;tool development;Training;Transcript;transcription factor;Translating;translational applications;Tribolium;Visualization;Work

PROJECT_TITLE: Dissecting input-output relationships of Developmental BMP Signaling

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Post-Traumatic Stress Disorder (PTSD);Pregnancy;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Posttraumatic stress disorder (PTSD) experienced during pregnancy and the postpartum period can have a profound effect on an individual’s mental and physical health. There is a critical need to engage Black women and rural-dwelling women in perinatal PTSD treatment as they are often the most likely to experience trauma exposure and subsequent PTSD symptoms, yet rarely receive targeted PTSD treatment; engaging perinatal individuals in PTSD treatment is critical as there are serious risks associated with untreated perinatal PTSD that often extend into the next generation. The proposed study (the New Empowerment after eXposure to Trauma (NEXT) Study) will evaluate the acceptability and feasibility of a brief perinatal PTSD intervention specifically targeting engagement and retention of Black women and rural-dwelling women.

PI_NAMEs: MILLER, MICHELLE LOUISE (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: acceptability and feasibility;Address;Adverse event;Affect;Aftercare;Award;biological adaptation to stress;Black race;black women;career;Career Choice;Caring;Clinical;Clinical Research;Clinical Trials;Clinics and Hospitals;Communities;community academic partnership;community engagement;comparison control;comparison group;Complex;Conduct Clinical Trials;Control Groups;Data;Data Collection;Death Rate;design;Drops;DSM-V;effective therapy;Eligibility Determination;empowerment;Enrollment;Environment;Evaluation;Evidence based treatment;Exhibits;experience;follow-up;Foundations;Goals;Health;health disparity;health equity;Healthcare;high risk;improved;Indiana;Individual;Infant Mortality;interest;Intervention;Literature;Manuals;Maternal Health;Maternal Mortality;Measures;medical schools;Mental Health;Mentors;Mentorship;Methodology;Methods;minority engagement;Minority Groups;Multiple Trauma;next generation;Outcome;Participant;Perinatal;perinatal health;perinatal outcomes;perinatal period;perinatal women;physical conditioning;Pilot Projects;pilot trial;Population;Post-Traumatic Stress Disorders;Postpartum Depression;Postpartum Period;Postpartum Women;Pre-Eclampsia;Pregnancy;pregnant;Pregnant Women;Premature Birth;Protocols documentation;Randomized;recruit;Research;Risk;Risk Factors;Rural Population;rural residence;Sampling;screening;Severities;skills;standard care;Structure;Symptoms;Testing;Therapeutic Intervention;Training;Training Activity;trauma exposure;treatment adherence;treatment as usual;treatment group;Underrepresented Populations;Underserved Population;Universities;uptake;Urban Population;urban underserved;virtual;Vulnerable Populations;Woman;Women's Group;Work

PROJECT_TITLE: Breaking the Cycle of Posttraumatic Stress Disorder for High-Risk Perinatal Populations

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Hearing Loss;Neurosciences;Rehabilitation

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: PROJECT NARRATIVE According to the World Health Organization's projections, by the year 2050, approximately 2.5 billion individuals are expected to experience varying degrees of hearing impairment, rendering sensorineural hearing loss and associated suprathreshold hearing disorders such as hyperacusis a significant healthcare problem. Recent research of neurodegenerative disorders and hearing loss suggests that in addition to neuronal factors, non-neuronal entities, particularly perineuronal nets (PNNs) and microglia, could play crucial roles in the pathogenesis of these disorders. PNN degradation and activated microglia are proposed as key contributors to central auditory neuron dysfunction after hearing loss, offering potential targets for therapeutic interventions to alleviate hearing loss and central gain disorders in the auditory cortex.

PI_NAMEs: KEMPFLE, JUDITH  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Acoustic Trauma;Adult;Auditory;Auditory area;auditory processing;Behavioral;Brain region;Cause of Death;Cell Death;Cells;Central Nervous System Diseases;Chronic;Cochlea;Data;Depressed mood;Development;Disease;Disinhibition;Elements;experience;experimental study;Extracellular Matrix;Extracellular Structure;Frequencies;Functional disorder;GABA Receptor;Glutamates;Healthcare;hearing impairment;Hearing problem;hippocampal pyramidal neuron;Homeostasis;Hour;Hyperactivity;Hyperacusis;Immune;Immune response;Individual;Inferior Colliculus;Inflammatory Response;Injury;Interneuron function;Interneurons;Intervention;loss of function;Loudness;Measurement;Mediating;Membrane;Metabolic;Microanatomy;Microglia;Modification;Mus;Natural regeneration;Neocortex;neural;Neurodegenerative Disorders;neuroinflammation;Neuronal Dysfunction;neuronal excitability;Neurons;Noise;noise exposure;optogenetics;ototoxicity;Oxidative Stress;Parvalbumins;Pathogenesis;Pathology;Peripheral;Pharmaceutical Preparations;Play;postsynaptic;presynaptic;prevent;Property;Protocols documentation;Recovery;Rejuvenation;Reporting;Research;response;Role;Sensorineural Hearing Loss;Signal Transduction;sound;Structure;Symptoms;Synapses;Synaptic plasticity;synaptic pruning;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Time;Tinnitus;tissue fixing;Toxic effect;Trauma;World Health Organization

PROJECT_TITLE: Plasticity of auditory cortex microglia and perineuronal nets after hearing loss


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health;Violence Research

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Elder mistreatment among ADRD caregivers remains understudied, in part because no measures of mistreatment exist which are tailored to this unique population. The proposed project seeks to iteratively develop a new measure of elder mistreatment among ADRD caregiver, grounded in user-centered design, soliciting feedback from caregivers and geriatric professionals at all stages of development and validation. The ultimate goals of this project are to create a measure which will advance the understanding of the rates of mistreatment among dementia family caregivers and identify factors related to rates of mistreatment among ADRD caregivers to inform future intervention development to reduce EM.

PI_NAMEs: HANCOCK, DAVID  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Age;Aging;Agitation;Alzheimer's disease related dementia;Behavioral Symptoms;care recipients;Caregivers;caregiving;caregiving research;Caring;cognitive interview;Complement;Data;Databases;Dementia;Dementia caregivers;dementia caregiving;design;Development;Distress;Elder Abuse;Elderly;Emotional;ERCC2 gene;ethnic diversity;Ethnic Origin;expectation;experience;Factor Analysis;Failure;Family;Family Caregiver;family caregiving;Family member;Feedback;Fostering;Friends;Funding;Future;Gender;General Population;Goals;Grant;Health;improved;Incidence;Individual;informal care;interest;Intervention;Interview;Knowledge;Lead;Leadership;Link;Literature;loved ones;maltreatment;Measurement;Measures;Mental Depression;Mentors;Modeling;modifiable risk;neglect;novel;older adult;Outcome;Participant;Patient Self-Report;Patients;Performance;Personal Satisfaction;Persons;pilot test;Policies;Population;Population Heterogeneity;Prevalence;prevent;Process;programs;Property;protective factors;psychologic;Psychometrics;Public Health;Publications;Qualitative Research;Quality of Care;Quality of life;Race;racial diversity;Readiness;Reporting;Research;Research Methodology;Research Personnel;Research Proposals;Research Training;response;Risk;Risk Factors;Role;Running;Sampling;Scientist;Self Efficacy;Sexual abuse;skill acquisition;skills;Socioeconomic Status;Stress;stressor;Structure;theories;therapy development;Thinking;tool;Training;Translating;Trust;United States National Institutes of Health;usability;user centered design;Validation;Work;Writing

PROJECT_TITLE: The EM-AD, a Novel Measure of Elder Mistreatment Among Dementia Family Caregivers

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Bioengineering;Brain Disorders;Cardiovascular;Clinical Research;Data Science;Depression;Diabetes;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Depression and anxiety are common among patients with cardiovascular disease (CVD) or diabetes mellitus (DM), having detrimental impact on these chronic conditions. This project will identify symptomatic issues, care needs, and at-risk subgroups of depression and anxiety in CVD and DM patients by analyzing patient portal messages and electronic health records using large language models and machine learning algorithms, approaches that can overcome the current multilayer barriers to timely detection. The findings will contribute to the preparation of targeted and tailored interventions, ultimately improving mental health outcomes.

PI_NAMEs: KIM, JIYEONG  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Algorithms;Anxiety;Anxiety Disorders;anxiety symptoms;Area Under Curve;Artificial Intelligence;artificial intelligence algorithm;Awareness;Behavioral;Bioethics;Biometry;Brain;burden of illness;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Models;career;career development;Caring;Chronic;Chronic Disease;Clinical;comorbid depression;comorbidity;Confidence Intervals;Data;depressive symptoms;design;Detection;Development;Development Plans;Diabetes Mellitus;Diagnosis;digital health;Discipline;Disease;Early Diagnosis;Electronic Health Record;Endocrinologist;Endocrinology;Environment;Epidemiology;Frequencies;generative artificial intelligence;Goals;Health;Health Personnel;health related quality of life;health service use;Health Status;Health system;Hospitalization;impaired functional status;improved;Individual;innovation;Institution;Intervention;Knowledge;large language model;Logistic Regressions;Machine Learning;machine learning algorithm;machine learning model;Medical Informatics;medical specialties;Mental Depression;mental disorder diagnosis;Mental disorders;Mental Health;mental health center;Mentors;Mission;Modeling;mortality;National Institute of Mental Health;Natural Language Processing;non-compliance;Odds Ratio;Outcome;patient engagement;patient oriented;patient population;patient portal;Patients;persistent symptom;Phase;Physiological;Population;Populations at Risk;predictive modeling;Preparation;Prevention;Provider;provider communication;Psyche structure;Psychiatrist;Psychiatry;Recovery;Research;Research Personnel;Risk;Risk Factors;risk prediction;risk prediction model;Series;Signal Transduction;skills;Solid;Specific qualifier value;Stigmatization;Subgroup;Symptom Burden;Symptoms;Testing;Text;Time;Training;Validation;Visit;Weight

PROJECT_TITLE: Leveraging Large Language Models and Machine Learning Algorithms to Assess Depression and Anxiety Symptoms and Risks for Patients with Cardiovascular Disease or Diabetes Mellitus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-N (90)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cost Effectiveness Research;Hematology;Orphan Drug;Prevention;Rare Diseases

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative There is no publicly available health economic model of therapeutic strategies in hemophilia A. Published models are limited by study heterogeneity, industry sponsorship, and lack of public availability. Using microsimulation, equity impact, value of information, and pharmacoepidemiologic analyses, the applicant will quantify the risks, benefits, and costs of time-variant prophylactic strategies in hemophilia A.

PI_NAMEs: GOSHUA, GEORGE  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: aging population;Benchmarking;beneficiary;Benefits and Risks;Budgets;Calibration;care costs;career development;Caring;Categories;Child;Clinical;Clinical Trials;Cohort Analysis;Collaborations;cost;cost effective;cost effectiveness;Cytomegalovirus Infections;Data;Data Collection;Databases;Decision Making;design;Diagnostic;Disease;economic evaluation;Economic Models;economic value;Ensure;Equity;Evaluation;Explosion;Factor Analysis;FDA approved;frontier;Funding;Future;gene therapy;Goals;Half-Life;Health;health economics;Health Policy;Health system;Hematological Disease;Hematology;Hemophilia A;Hemorrhage;Heterogeneity;Incidence;inclusion criteria;Industry;Infrastructure;inhibitor;Institution;life span;life time cost;lifetime risk;Medicare Part B;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Modeling;models and simulation;Observational Study;Patient Care;patient subsets;Patients;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Phenotype;Play;Prevention;Prevention strategy;prophylactic;Prophylactic treatment;prospective;Publishing;Quality of life;recombinant antihemophilic factor VIII;Recommendation;Recording of previous events;Research;Research Personnel;Research Priority;Research Project Grants;research study;Resource Allocation;Risk;Science;Scientist;Secondary to;Severities;Severity of illness;simulation;skills;standard of care;Structure;Techniques;Therapeutic;Time;Training;Treatment Cost;treatment strategy;Variant;Weight;Work

PROJECT_TITLE: Targeted, adaptive and time-variant strategies for bleed prevention across the lifespan for persons with hemophilia A

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Despite extensive characterization, we struggle to understand and control the progression of human-associated microbial communities, including bacterial vaginosis (BV), a condition that is directly impactful to women’s health and the acquisition of sexually transmitted infections. This proposal investigates single-cell genomic and transcriptomic heterogeneity as two underexplored areas that impact the progression of BV. This intellectually and methodologically innovative research will transform our understanding of the development, treatment, and recurrence of BV and will provide broad-reaching insights into new strategies to prevent and treat polymicrobial infections.

PI_NAMEs: LEWIN, GINA  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Address;Aftercare;aged;Anti-microbial susceptibility;Antibiotics;antimicrobial;Area;bacterial community;Bacterial Physiology;Bacterial Vaginosis;Behavior;Candidiasis;Cells;Clinical;Clinical Research;Communities;Complex;Data;Development;Diagnosis;Disease;Disease Outcome;dysbiosis;Ecology;Economic Burden;effective therapy;expectation;experience;Exposure to;female reproductive tract;Gardnerella vaginalis;Genetic Transcription;Genomics;Goals;Health;Heterogeneity;HIV;human microbiota;Human Papillomavirus;Immune response;In Vitro;Individual;Infection;innovation;insight;interest;Invaded;Maintenance;Malignant neoplasm of cervix uteri;Measures;Mediating;Methodology;Microbe;microbial;microbial community;microbiome;microbiome alteration;microorganism interaction;Microscopy;National Institute of Allergy and Infectious Disease;North America;novel strategies;Odors;Pain;pathobiont;pathogen;Pathogenesis;Patients;Pelvic Inflammatory Disease;Phenotype;polymicrobial disease;Pre-Clinical Model;Predisposition;Premature Birth;prevent;Prevention;Prevention approach;Prevention strategy;Recurrence;reproductive;Research;Resistance;response;Role;Sampling;Sexually Transmitted Diseases;single cell genomics;single-cell RNA sequencing;Site;Specimen;Taxonomy;Testing;trait;transcriptomics;treatment response;tumor progression;United States;Urinary tract infection;Vagina;vaginal microbiome;vaginal microbiota;Variant;virtual;Woman;Women's Health;Work

PROJECT_TITLE: Defining the role of single-cell heterogeneity in bacterial vaginosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-D (M1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: WALTHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Narrative  Human-induced pluripotent stem cells (iPSCs) have enormous potential for generating a variety of cell types for cell therapy but are impeded by the tumorigenic risk of residual iPSCs in cell mixtures during differentiation. The proposed study aims to develop new peptide assemblies to selectively eliminate unwanted human iPSCs in cell mixtures for cell therapy. The success of this project will ensure the safety of cell therapy, thereby enhancing the treatment of human diseases.

PI_NAMEs: XU, BING  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;Affect;Alkaline Phosphatase;Biocompatible Materials;Cell Therapy;Cell Transplantation;cell type;Cells;Cellular Assay;clinical application;clinically relevant;cost;design;Development;efficacy evaluation;Ensure;Environment;Enzymes;Evaluation;Exhibits;Goals;Hematopoietic stem cells;Hour;human disease;human induced pluripotent stem cells;immunodeficiency;improved;in vivo;induced pluripotent stem cell;innovation;invention;Location;Methods;Modeling;Morphology;mouse model;multidisciplinary;Mus;nano;Normal Cell;novel strategies;Nuclear;overexpression;peptide L;Peptide Synthesis;Peptides;Performance;personalized medicine;Phase;Photoreceptors;precursor cell;prevent;Process;Protein Dephosphorylation;Proteolysis;Reaction;Reporting;Research;Residual state;Risk;Safety;self assembly;side effect;Solid;spatiotemporal;stem cells;Structure;success;Teratoma;Time;Transplantation;tumor;tumorigenic;Tumorigenicity

PROJECT_TITLE: Selectively eliminating residual human induced pluripotent stem cells (iPSCs) in cell mixtures for cell therapy

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Eczema / Atopic Dermatitis;Infectious Diseases;Microbiome;Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Staphylococcus aureus is a leading cause of human skin infections and colonizes up to 90% of itchy skin lesions in patients with Atopic Dermatitis. This proposal will investigate the role of S. aureus itch and neuro-immune signaling in driving skin damage and immune responses. These studies will reveal novel mechanisms of itch, inflammation, and neuron signaling and further our understanding of how microbes contribute to Atopic Dermatitis pathology.

PI_NAMEs: DENG, LIWEN  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 16S ribosomal RNA sequencing;Ablation;Afferent Neurons;Age;antagonist;Architecture;Atopic Dermatitis;Automobile Driving;Award;Back;Bacteria;Behavior;Biological;Biological Assay;Cells;Characteristics;chronic itch;Complex;Confocal Microscopy;cytokine;Data;Defect;defined contribution;density;Dermatitis;Disease;Distal;dysbiosis;Enzyme-Linked Immunosorbent Assay;Epidermis;Esthesia;experience;Exposure to;Extramural Activities;Flow Cytometry;Foundations;Funding;genetic approach;Genetic Transcription;glutamyl endopeptidase;Goals;Health;Home;host-microbe interactions;Human;Immune;Immune response;Immunologics;Immunology;immunoregulation;Induced Neurons;Infectious Skin Diseases;Inflammation;Inflammatory;Label;Link;Measures;Mediating;Mediator;Mentorship;Microbe;microbial;Microbiology;microbiome;Modeling;Molecular;mouse model;Mus;Mutation;Nerve;Nerve Fibers;nerve supply;Neurobiology;Neuroimmune;Neurons;Neuropeptides;neurotransmission;novel;Operative Surgical Procedures;opportunistic pathogen;Organ;PAR-1 Receptor;Pathologic Processes;Pathology;Patients;Phase;Population;Production;Proteinase-Activated Receptors;Pruritus;Publications;Publishing;Quality of life;receptor;recruit;Reflex action;Reporter;Research Personnel;Research Proposals;response;Role;Sampling;Serine Protease;Signal Transduction;Site;skills;Skin;skin barrier;Skin colonization;skin damage;skin disorder;skin lesion;skin microbiome;Spinal Ganglia;Staphylococcus aureus;Symptoms;Techniques;Time;Touch sensation;Training;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Staphylococcus aureus induced itch and neuro-immune signaling in skin inflammation and atopic dermatitis

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Patient Safety

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Peter Abadir, MD is a Geriatrician at Johns Hopkins University whose research and clinical focus for the past 15 years has been on the molecular mechanisms underlying age-related physical and cognitive decline. This career development award will provide him with additional training and protected time to identify, recruit, and mentor young, motivated scholars, and to undertake rigorous training. His development plans include educa- tion and mentorship in patient-oriented research, with a focus on using various sensors and artificial intelli- gence tools to identify and predict outcomes in frail older individuals, as well as linking these outcomes to mo- lecular biomarkers that underlie Frailty and Alzheimer's disease.

PI_NAMEs: ABADIR, PETER M. (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Achievement;adverse outcome;Affect;Age;age related;aged;Aging;Alzheimer's Disease;American;Artificial Intelligence;Attention;Biological;Biology;Biometry;Body Weight decreased;care outcomes;career development;Categories;Characteristics;Clinical;Clinical Data;Clinical Research;clinical translation;Cognitive;Cognitive deficits;cognitive process;cohort;collaboratory;Computer Analysis;Computers;cytokine;Data;Data Analyses;Dedications;Detection;Development Plans;digital;Early Diagnosis;Education;Elderly;Engineering;Ensure;Environment;Evaluation;Exhibits;experience;Eye Movements;Frail Elderly;frailty;Funding;Future;Gait;gait examination;Geroscience;Goals;Grant;Grouping;hands on research;Handwriting;Heterogeneity;Iatrogenesis;Impaired cognition;Individual;innovation;insight;Institution;interest;K-Series Research Career Programs;Knowledge;Leadership;Learning;Link;Measurement;Measures;Medicine;meetings;Mentors;Mentorship;metabolomics;Methodology;Methods;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Molecular;molecular marker;Molecular Profiling;mortality;Motor;Motor Activity;multimodality;Muscle;Muscle Weakness;novel strategies;older adult;Older Population;Outcome;outcome prediction;Participant;patient oriented research;Patients;Pattern;Phenotype;Physical assessment;prevent;programs;Recovery;recruit;Research;Research Personnel;Research Training;Resources;Risk;Role;Sampling;Scientist;Sensitivity and Specificity;sensor;Serum;Signal Transduction;skills;Specificity;Speech;Structure;Subgroup;Syndrome;technological innovation;Technology;Time;tool;Training;Training Programs;Translational Research;Underrepresented Minority;Universities;Validation;Voice

PROJECT_TITLE: AI-Driven Frailty Assessment and Molecular Correlation: A Multimodal Mentorship Initiative

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Aging-associated somatic mutational spectra are a record of an organism’s lifelong attempts to maintain cellular homeostasis. Uncovering the mechanisms underlying longevity-associated mutational signatures furthers the NIA’s goal of understanding the biology of aging by improving our understanding of the progression of an aging-related biomarker, and by enabling the discovery of novel processes that lead to aging-related disorders.

PI_NAMEs: VAZQUEZ, JUAN MANUEL (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Address;Age;Aging;aging process;aging related;Animals;Automobile Driving;Biological;Biological Markers;Biology;Biology of Aging;Cause of Death;Cell Line;cell type;Cells;Chiroptera;Collaborations;Collection;combinatorial;Comparative Biology;comparative genomics;Controlled Environment;CRISPR interference;Data;Dementia;design;Development;differential expression;directed differentiation;Disease;DNA Damage;DNA Double Strand Break;DNA Repair;Embryoid bodies;Evolution;experimental study;Fibroblasts;follow-up;Foundations;functional genomics;Future;gene repair;Genes;Genetic;Genomics;Goals;hallmarks of aging;Heart Diseases;Homeostasis;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;interest;knock-down;Knowledge;Libraries;Life;life span;Longevity;Longitudinal Studies;Malignant Neoplasms;Mammals;Mitotic;Mutation;Mutation Spectra;Names;nano;North America;novel;Organ;Organism;Organoids;Pattern;Positioning Attribute;Process;programs;Protocols documentation;rate of aging;Recording of previous events;repaired;Research;Research Personnel;Resolution;response;Risk Factors;Sample Size;Sampling;single cell sequencing;Skin;skin biopsy;Skin Tissue;Somatic Mutation;Stress;Surveys;Taxonomy;Techniques;Testing;Time;Tissue Sample;Tissues;trait;Trees;Variant;Wing;Work

PROJECT_TITLE: Patterns and Mechanisms Underlying Somatic Mutations Across Long-Lived Bats

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric

ORG_CITY: MILWAUKEE

ORG_DEPT: SURGERY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Kleefstra Syndrome is a rare genetic neurodevelopmental syndrome resulting from EHMT1 gene haploinsufficiency, presenting with intellectual disability, developmental delay, facial features, and childhood hypotonia, often co-occurring with autism spectrum disorders. Studying the impact of EHMT1 genomic variants on its protein structure and function is crucial for advancing our understanding of Kleefstra Syndrome and potentially improving therapies to benefit affected patients. Ultimately, these findings may have broader relevance for addressing neurodevelopmental disorders, enhancing public health efforts in this field.

PI_NAMEs: CHI, YOUNG-IN ;URRUTIA, RAUL A. (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Alleles;Amino Acid Sequence;Animal Model;Ankyrin Repeat;Ankyrins;autism spectrum disorder;Binding;Biochemical;Biophysical Process;biophysical properties;biophysical techniques;Biophysics;Catalytic Domain;Cells;Child;Childhood;Chromatin;Classification;ClinVar;comorbidity;Computing Methodologies;Data;Decision Making;Development;Developmental Delay Disorders;Diagnostic;Disease;Disease Management;disease-causing mutation;Elements;Enzymes;Epigenetic Process;euchromatic histone methyltransferase 1;experimental study;Face;Family;Foundations;Functional disorder;Future;Genes;Genetic;genetic variant;Genetic Variation;genomic variation;Goals;Histone H3;histone methylation;Histones;human disease;improved;insight;Intellectual functioning disability;Investigation;Knowledge;Link;Lysine;Mediating;Methods;Molecular;Muscle hypotonia;mutant;Mutation;Neurodevelopmental Disorder;novel;novel therapeutic intervention;Pathogenesis;Pathogenicity;Patients;Personal Satisfaction;personalized approach;Phenotype;precision medicine;protein function;protein structure;protein structure function;Proteins;Public Health;Reader;Regulation;scaffold;SET Domain;Structure;Structure-Activity Relationship;Study models;Supersecondary Protein Structure;Syndrome;Testing;Therapeutic;Variant;variant of unknown significance

PROJECT_TITLE: Insights into EHMT1 Variants in the Neurodevelopmental Disorder Kleefstra Syndrome through Structural Dynamics and Functional Analysis

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]