ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: ORTHOPEDICS

PHR: NARRATIVE As one of the fastest growing health problems, OA affects 54 million people in the United States and more than 300 million people globally, however, there are currently no interventions to restore degraded articular cartilage or prevent OA progression. This proposal provides new mechanistic insights towards understanding the role of TGFβ/Nfia in regulation of articular chondrocyte lipid metabolism and homeostasis in the context of OA disease. We will define Nfia-mediated lipid metabolism as a novel target for the development of therapeutic approaches to treat OA.

PI_NAMEs: SHEN, JIE  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Ablation;Acetyl-CoA Carboxylase;Address;Affect;Aging;Arthritis;articular cartilage;ATAC-seq;Attenuated;Binding;Carnitine Palmitoyltransferase I;Cartilage;cartilage degradation;Cells;Chondrocytes;Critical Pathways;Data;Degenerative polyarthritis;Disease;Enzymes;Etiology;Fatty Acids;functional restoration;Gene Deletion;Genes;Genetic;genetic approach;Goals;Health;Homeostasis;Human;In Vitro;in vivo;Injury;innovation;insight;Intervention;joint injury;Joints;Knowledge;lipid metabolism;loss of function;Mediating;Mediator;metabolomics;multiple omics;Mus;NFIA gene;novel;Obesity;overexpression;oxidation;Pain;Pathogenesis;Pathway interactions;Patients;Persons;Play;prevent;Promoter Regions;receptor;Regulation;RNA analysis;Role;Sclerosis;screening;single-cell RNA sequencing;Synovitis;TGFBR2 gene;Therapeutic;therapeutic development;therapeutic target;transcription factor;transcriptome sequencing;Transforming Growth Factor beta;United States;Up-Regulation

PROJECT_TITLE: Lipid Metabolism in Articular Cartilage and OA Pathogenesis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Disability Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: MONTGOMERY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_FIPS: US

ORG_NAME: ALABAMA STATE UNIVERSITY

ORG_STATE: AL

PHR: Project Narrative We propose to measure trunk function in those with physical disability using novel tests. The proposed tests are the Volume of Action Score and the Trunk Stability Score. They evaluate limits of stability and the ability to resist an outside force respectively. These test build upon current methods to create precise measures that give more robust information related to functional outcomes. We plan evaluate the relationships of these measures to other functional measures and related factors.

PI_NAMEs: REHM, JARED  (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Adopted;Affinity;Area;Articular Range of Motion;biceps brachii muscle;Bilateral;Clinical;clinical care;Computer software;cost;Data;Data Collection;Degree program;Development;disability;Disabled Persons;Educational workshop;Electromyography;Elements;Equipment;experience;Exposure to;field study;Floor;foot;functional outcomes;Gastrocnemius Muscle;graduate student;Healthcare;Human;Impairment;improved outcome;Individual;Individuals with physical disabilities;Injury;innovation;insight;interest;Intervention;Journals;kinematics;Kinesiology;Lasers;Lead;Learning;lectures;Lower Extremity;Measurement;Measures;Methods;Mobility decline;Motion;motor impairment;Movement;Muscle;Nature;Normal Range;novel;Participant;Performance;Physical activity;Physical Function;physical impairment;physically handicapped;portability;pressure;Procedures;recruit;rectus femoris;Rehabilitation therapy;Research;Sampling;Signal Transduction;skills;Students;Surface;Testing;Time;tool;Training;Treatment Efficacy;undergraduate student;Underrepresented Minority;Validity and Reliability;Visual;wearable sensor technology;Wheelchair propulsion;Wheelchairs

PROJECT_TITLE: Enhancing Measures of Trunk Function in those with Physical Impairment

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-A (SU)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: IOWA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Although tau is best known for its role in Alzheimer disease, it is a major driver of brain injury in hypoxic-ischemic injury and two of its early life sequelae – autism and epilepsy. Tau-targeted agents are already under development for Alzheimer disease and could be readily adapted to treat these devastating developmental problems, but it is unclear whether tau is necessary for normal development. Without this knowledge further development of this potentially highly promising therapeutic strategy is unlikely.

PI_NAMEs: HEFTI, MARCO MATTHIAS (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Adult;Alzheimer's Disease;autism spectrum disorder;Axon;Binding;Biological Models;Brain;Brain Injuries;Cell Line;Data;Dendrites;Development;Disease;Ensure;Epilepsy;experimental study;fetal;gain of function;Goals;Human;human fetal brain;human model;human stem cell-derived;human stem cells;hypoxic ischemic injury;Impairment;In Vitro;Knock-in Mouse;Knock-out;Knowledge;Life;Literature;Microtubules;Mus;N-Methyl-D-Aspartate Receptors;network dysfunction;neurodevelopment;Neurodevelopmental Disorder;Neurons;neurotoxicity;Outcome;Pathology;Pathway interactions;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Physiological;postnatal;Process;protein function;Proto-Oncogene Proteins c-fyn;Publishing;Quality of life;Receptor Signaling;Reducing Agents;Rodent;Role;Safety;Stress;Structure;Synapses;targeted agent;targeted treatment;tau function;tau Proteins;tau-1;Testing;Therapeutic;therapeutic target;Toxic effect;Translating;Up-Regulation

PROJECT_TITLE: A non-canonical role for tau in early human brain development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-W (92)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: CAMBRIDGE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative and Public Health Relevance:  We propose to develop a research instrument that will allow stimulating biological cells with various chemical or biological compounds and then freezing these cells for subsequent analysis by high-resolution microscopy. This instrument will be useful in studying how cells respond to hormones, neurotransmitters, drugs, viruses, and many other agents relevant both to human physiology and disease. The project integrates a series of conceptual and methodological innovations that will result in a novel approach to nanoscale imaging of normal and aberrant cellular dynamics.

PI_NAMEs: PRIGOZHIN, MAXIM  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;acronyms;Address;Agonist;Biological;biological research;biological systems;biophysical techniques;biophysical tools;cell fixing;Cell Physiology;cell type;Cells;Cellular biology;cellular imaging;Cellular Membrane;Chemical Stimulation;Chemicals;Collaborations;commercialization;Cryo-electron tomography;Cryoelectron Microscopy;cryogenics;cytokine;Data;Data Analyses;Development;Devices;Disease;Educational workshop;experimental study;Face;falls;fluorescence imaging;Foundations;Freeze Substitution;Freezing;Future;Glass;Goals;high resolution imaging;Hormones;Human;Ice;Image;imaging modality;Immersion;innovation;instrument;instrumentation;Investigation;Ions;Ligands;Liquid substance;live cell imaging;Maps;Measurement;Membrane Proteins;Methodology;Methods;Microscopy;millisecond;Molecular;nanoscale;Neurotransmitters;novel strategies;Nucleic Acids;open source;Optics;Peptides;Pharmaceutical Preparations;pharmacologic;Physical condensation;Physiological;Physiology;Post-Translational Protein Processing;Preparation;pressure;prevent;Procedures;Protein Dynamics;Proteins;Protocols documentation;prototype;public health relevance;Publications;Qualifying;Research;Resolution;response;Retinal blind spot;risk mitigation;Sampling;Series;single molecule;small molecule;spatiotemporal;Stimulus;Surveys;technique development;Techniques;Technology;temporal measurement;Testing;Time;ultra high resolution;Ultrasonics;Validation;Virus;vitreous state;Work

PROJECT_TITLE: Dynamic nanoscale cellular imaging via time-resolved cryo-vitrification

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: HERSHEY

ORG_DEPT: PEDIATRICS

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: NARRATIVE  Colorectal cancer (CRC) is a lethal disease with limited treatment options. Pilot studies suggest that regulators of levels of the β-TrCP E3 ubiquitin ligase such as IGF2BP1 and PARP11 may contribute to CRC tumor growth, its control by anti-tumor immunity and responses to chemotherapy. Studies proposed here will determine the importance of IGF2BP1 and PARP11 in growth, progression, and metastasis of colorectal tumors and in their responses to therapy; these studies should reveal the IGF2BP1- and PARP11-dependent pathways as vulnerabilities that could be exploited for CRC treatment.

PI_NAMEs: FUCHS, SERGE Y;SPIEGELMAN, VLADIMIR S. (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Ablation;Adenocarcinoma Cell;ADP ribosylation;anti-cancer;anti-cancer therapeutic;anti-tumor agent;antitumor effect;Benign;beta catenin;beta-Transducin Repeat-Containing Proteins;cancer cell;Cells;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;cohort;Colon Adenocarcinoma;colon cancer patients;colon growth;Colonic Neoplasms;Colorectal Cancer;colorectal cancer treatment;Colorectal Neoplasms;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Deceleration;Disease;Down-Regulation;Epithelial Cells;Exhibits;Genetic;Growth;Human;I Kappa B-Alpha;IFNAR1 gene;Immune system;improved;In Vitro;in vivo;inhibitor;insight;Interferon Type I;intestinal epithelium;Intestinal Neoplasms;Knock-out;Legal patent;Link;Malignant Neoplasms;Messenger RNA;Metastatic Neoplasm to the Liver;Molecular;multicatalytic endopeptidase complex;Neoplasm Metastasis;neoplastic cell;Non-Malignant;novel;Pathogenesis;Pathway interactions;Patients;Persons;pharmacologic;Phenotype;Pilot Projects;Play;Poly(ADP-ribose) Polymerases;Polymerase;Process;Prognosis;Proliferating;Proteins;Proteolysis;Public Health;Publishing;Regimen;Research;Resistance;response;RNA-Binding Proteins;Role;Signal Pathway;standard of care;Testing;Therapeutic;treatment response;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-infiltrating immune cells;tumorigenic;type I interferon receptor;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Up-Regulation

PROJECT_TITLE: Targeting ß-TrCP regulators to improve CRC response to chemotherapy

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Genetic Testing;Genetics;Immunization;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PHOENIX

ORG_NAME: BANNER HEALTH

ORG_STATE: AZ

PHR: Project Narrative The proposed project (Alzheimer's Prevention Initiative ADAD Colombia Program) is intended to clarify whether a clinically effective anti-amyloid antibody therapy reduces amyloid plaques and other biomarker evidence of disease progression in mildly impaired and unimpaired persons from the in the world's largest early onset, autosomal dominant Alzheimer's disease (ADAD) kindred to the same extent as it does in independent studies of late onset AD. The study will also characterize and compare the ability of continued antibody treatment, a potentially more accessible oral amyloid production inhibitor, a combination of these drugs or no drug to further decrease measurable plaques and other biological changes; it will provide a foundation to determine whether these treatments slow down, delay, or completely prevent the clinical onset of ADAD in the impaired and unimpaired mutation carriers; and it will provide an shared resource for the scientific community of trial data and samples from all study participants. The study capitalizes on an established late-onset AD-modifying drug and a promising new “gamma-secretase” modulator, and uses the clinical trial infrastructure that we established in Colombia and at Banner Alzheimer's Institute to advance the treatment, secondary prevention, primary prevention, and study of AD.

PI_NAMEs: ALEXANDER, ROBERT C (contact);LANGBAUM, JESSICA BROOKE;QUIROZ, YAKEEL T.;REIMAN, ERIC MICHAEL

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: abeta accumulation;Address;Affect;Age;Age Years;Agreement;Alzheimer disease prevention;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Antibodies;Antibody Therapy;autosomal dominant Alzheimer's disease;Biological;Biological Markers;blind;Blood specimen;blood-based biomarker;Brain;carrier status;Clinical;clinical effect;Clinical Trials;Cognitive;cognitive testing;Collaborations;Colombia;Colombian;Combined Modality Therapy;Community Trial;Data;data sharing networks;Dementia;design;Detection;Developing Countries;Development;Disease Progression;Double-Blind Method;Drug Combinations;Early Diagnosis;early onset;efficacy evaluation;Ethics;experience;Foundations;Funding;Future;gamma secretase;Guidelines;Human Resources;Image;Impaired cognition;Impairment;Individual;Inflammatory;Infrastructure;Infusion procedures;inhibitor;Intervention;intervention effect;Intervention Studies;Investigation;Investments;kindred;Ligands;Magnetic Resonance Imaging;Measurable;Measurement;member;Mentors;mutation carrier;Nerve Degeneration;older adult;Oral;Participant;Patients;Persons;Pharmaceutical Preparations;Placebo Control;placebo group;Placebos;Plasma;Population;Positron-Emission Tomography;pre-clinical;presenilin-1;prevent;Prevention Research;Prevention therapy;Prevention trial;Primary Prevention;Production;programs;Randomized;recruit;Registries;Research Personnel;Resource Sharing;Risk;Role;Sampling;Secondary Prevention;Senile Plaques;Social support;tau Proteins;Testing;treatment group;United States National Institutes of Health;virtual;Vulnerable Populations

PROJECT_TITLE: Alzheimer's Prevention Initiative ADAD Colombia Trial Program

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative: Despite the major advancement in the development of new therapies for the treatment of human prostate cancer, prostate cancer remains the second leading cancer cause of death in north American men. Therefore, there is an urgent need to develop new and more effective therapies for the treatment of human prostate cancer, particularly metastatic, castration-resistant prostate cancer. In this R01 award, we propose to develop orally active CBP/p300 degraders as a new class of therapy for the treatment of advanced, human prostate cancer.

PI_NAMEs: WANG, SHAOMENG  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: abiraterone;Address;American;androgen independent prostate cancer;Androgen Receptor;Androgens;Animal Model;antagonist;anticancer activity;AR gene;Award;Binding Proteins;Biological Availability;Biological Process;Bromodomain;c-myc Genes;Cancer Etiology;cancer therapy;Cause of Death;cell growth;Cessation of life;Clinical Data;clinical development;Clinical Trials;CREBBP gene;Data;design;Development;Dose;Down-Regulation;Drug Kinetics;E1A-associated p300 protein;effective therapy;enzalutamide;EP300 gene;Estrogen Receptors;Evaluation;Gene Amplification;Generations;Genes;Goals;Grant;Growth;histone acetyltransferase;Human;human disease;human model;improved;in vitro activity;in vivo;inhibitor;Investigation;Laboratories;Lead;Length;Ligand Binding Domain;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metabolic;mouse model;Mus;Mutate;Mutation;nanomolar;neoplastic cell;novel therapeutic intervention;novel therapeutics;Oral;Oral Administration;Patients;Phase;Play;preclinical development;prostate cancer cell line;Prostate Cancer therapy;prostate carcinogenesis;Protein Binding Domain;Protein Degradation Induction;Proteins;Rattus;Receptor Signaling;Reporting;Resistance;resistance mechanism;RNA Interference;Role;Schedule;Signal Transduction;small hairpin RNA;small molecule;small molecule inhibitor;targeted treatment;Technology;Therapeutic;Therapeutic Index;therapeutic target;therapy development;Toxic effect;Transcription Coactivator;transcription factor;tumor growth;Tumor Tissue;Variant

PROJECT_TITLE: Orally active CBP/p300 degraders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DMPC-J (90)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative / Relevance Human pluripotent stem cells have the capacity to give rise to any other cell type found in the body, including blood forming stem cells and their derivative immune cell progeny. The goal of this proposal is to understand how these processes occur, and, if the blood cell types obtained are functionally distinct from donor-derived sources. This will allow for technology development to scalably generate each of these blood cell types from a patient’s own cells.

PI_NAMEs: STURGEON, CHRISTOPHER MICHAEL (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Adoptive Immunotherapy;Adult;ALDH1A2 gene;B-Lymphocytes;Bioinformatics;Biology;Blood Cells;Bone Marrow;CD19 gene;CD34 gene;cell replacement therapy;cell type;Cells;Characteristics;Clinical;CXCR4 gene;Dependence;Derivation procedure;Development;directed differentiation;Disease;disease model;Embryo;Erythroid;Exhibits;FGF2 gene;Genetic Transcription;Goals;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Home;homeodomain;Homing;HOXA9 gene;human pluripotent stem cell;human stem cells;Immune;Immunotherapeutic agent;In Vitro;in vivo;insight;Length;Life;Lymphoid;Lymphoid Cell;Methodology;Methods;Molecular;Multipotent Stem Cells;Mus;Myelogenous;novel;Patients;peripheral blood;personalized medicine;Physiological;Pluripotent Stem Cells;Population;Positioning Attribute;Process;progenitor;Property;Protocols documentation;Regulation;Research;RNA Splicing;Role;self-renewal;Signal Pathway;Signal Transduction;Source;Specific qualifier value;stem cell biology;Stem Cell Development;stem cells;Study models;T-Cell Proliferation;technology development;Testing;tool;Transcript;transcription factor;Transgenes;translational potential;Tretinoin;Vascular Endothelial Growth Factors;Xenograft procedure

PROJECT_TITLE: Characterization of multilineage definitive hematopoietic progenitors from human pluripotent stem cells

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Rare Diseases;Rural Health;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The rural Appalachian region has a markedly high prevalence of cigarette smoking, contributing to disparities in lung and oral cancers. We propose to evaluate the effectiveness of a potentially reduced harm nicotine product, oral nicotine pouches, on reducing smoking in a large sample of rural Appalachian smokers. Results from this innovative investigation of oral nicotine pouches will inform whether they can be useful to reduce the burden of smoking in rural Appalachia.

PI_NAMEs: KELLER-HAMILTON, BRITTNEY L (contact);WAGENER, THEODORE LEE

PROGRAM_OFFICER_NAME: KAUFMAN, ANNETTE R

PROJECT_TERMS: Abstinence;Adult;Advertisements;Appalachian Region;Area;arm;Behavior;Behavioral;cancer health disparity;Carbon Monoxide;Carcinogens;Cigarette;Cigarette Smoker;cigarette smoking;County;craving;Data;Death Rate;Dependence;detection limit;Disparity;Economics;effectiveness evaluation;Farm;Foundations;Frequencies;Harm Reduction;health care availability;Health Insurance;Health Personnel;Healthcare Systems;High Prevalence;Incidence;Individuality;Industry;innovation;Intervention;Investigation;Lead;malignant mouth neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Marketing;Medicine;Nicotine;Nicotine Dependence;nicotine replacement;Nicotine Withdrawal;novel strategies;Oral;Outcome;Participant;Patient Self-Report;Pattern;Phase;Population;Poverty;Prevalence;Public Health;Randomized;Regulation;Reporting;Rural Appalachia;Sampling;Services;Smoke;Smoker;Smoking;smoking cessation;smoking-related cancer;social;success;Surveys;Testing;Tobacco;tobacco control;Tobacco Industry;tobacco products;Tobacco use;toxicant;United States;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Testing Oral Nicotine Pouches to Reduce Smoking-Related Cancer Disparities in Appalachia

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orthopoxviruses;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE We still do not understand why variola, the cause of smallpox and one of the deadliest pathogens in human history, and its close orthopoxvirus relatives, such as monkeypox virus, are so dangerous. In this project we focus on the B22 family of proteins, a single version of which is made by nearly all orthopoxviruses. B22 proteins potently interfere with immune responses by the infected individual in a combination of ways that has not been previously described. Gaining an understanding of how B22 proteins operate could provide key insights into orthopoxvirus virulence and point to novel anti-viral strategies.

PI_NAMEs: EISENLOHR, LAURENCE CRANE (contact)

PROGRAM_OFFICER_NAME: LINDE, AMBER SHRYER

PROJECT_TERMS: 3-Dimensional;Alaskapox virus;base;Binding;Biochemical;Bioterrorism;Biotin;Biotinylation;C-terminal;camelpox virus;Categories;CD8-Positive T-Lymphocytes;Cells;Complex;Dangerousness;Data;Development;Disease;Disease Outbreaks;Doxycycline;Ectromelia;Effector Cell;emerging virus;Epitopes;Family;Family member;Foundations;Fright;Future;Glycoproteins;Health;Host Defense;Human;human pathogen;Imaging Techniques;Immune response;Immunoprecipitation;In Vitro;in vitro Assay;in vivo;Inbred BALB C Mice;Individual;Infection;Infectious Ectromelia;insight;interest;Investigation;Lentivirus;Ligase;Location;Maps;Mediating;member;Membrane;MHC Class I Genes;Modeling;Monkeypox virus;mortality;Mouse Pox Virus;Mus;N-terminal;Natural Killer Cells;Nature;NK Cell Activation;nonhuman primate;novel;novel therapeutic intervention;Orthopoxvirus;pathogen;Pathogenicity;Phosphorylation;prevent;Property;Protein Family;Proteins;Publishing;Recombinant Proteins;Recombinants;Recording of previous events;Rodent;Site;Smallpox;Structure;System;Technology;Testing;Viral;Virulence;Virulence Factors;Virus;Work

PROJECT_TITLE: The B22 family of orthopoxvirus virulence factors: Investigating structure/function of these potent, multifaceted immunoevasins

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE  The proposed project is relevant to public health because proton therapy has reduced dose to healthy tissue vs. photon therapy and hence improves health, lengthens life, and reduces illness and disability in patients receiving external beam radiation therapy. Despite the fundamental dosimetric advantage of proton therapy, there are only 44 proton therapy centers in the USA due to the larger size, larger cost, and smaller economy of scale. We will determine the feasibility of reducing the gantry size while minimizing the impact to clinical capability and not complicating the design with superconductors, eccentric rotation, or seated treatments.

PI_NAMEs: CLASIE, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Air;Applications Grants;beamline;Clinical;commercialization;Computer software;cost;Custom;Dedications;design;Diameter;disability;Dose;Elements;Elevator;Evaluation;experience;External Beam Radiation Therapy;Floor;foot;General Hospitals;Goals;Government;Grant;Health;improved;Journals;Legal patent;Life;Linear Accelerator Radiotherapy Systems;Magnetism;Massachusetts;Patients;Peer Review;Persons;Photons;Protein Structure Initiative;proton therapy;Protons;prototype;Public Health;Publications;Radial;Radiation therapy;Recording of previous events;Rotation;Scanning;Source;Structure;Synchrotrons;System;Temperature;Tissues;Vendor;Work

PROJECT_TITLE: Mini-gantry for proton therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (J2)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE This proposal will assess acute air pollution mortality risk for individuals diagnosed with chronic respiratory diseases; a high-vulnerability group for environmental exposures. Using a patient data architecture built from clinical records, environmental conditions, and place-based characteristics of U.S. Veterans across a 20-year period, we will unpack the individual risk factors and neighborhood inequities that drive air pollution mortality risk in at-risk populations. Our findings will provide powerful insight into environmental risk for individuals with respiratory disease and inform regulatory policy and behavioral interventions to reduce health burdens in this population.

PI_NAMEs: BERMAN, JESSE DAVID (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Acute;Address;Age;Air;Air Pollution;air quality regulation;airway inflammation;ambient air pollution;Architecture;Area;Asthma;Behavior;Behavior Therapy;Behavioral;Body mass index;Bronchiectasis;burden of illness;Cardiovascular system;Caring;Censuses;Characteristics;Chronic Kidney Failure;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Clinical;cohort;Communities;community-level factor;comorbidity;Congestive Heart Failure;County;Crossover Design;Data;Databases;demographics;deprivation;design;Diagnosis;disease diagnosis;disorder risk;Disparity;Dose;Early identification;Electronic Health Record;Environment;Environmental Exposure;environmental justice;Environmental Risk Factor;Epidemiology;Ethnic Origin;Evaluation;Exhibits;experience;Exposure to;fine particles;Foundations;Future;Goals;hazard;Health;health disparity;Home;Income;indexing;Individual;individual patient;Inequity;Injury;innovation;insight;intersectionality;Interstitial Lung Diseases;Intervention;Joints;Lung;Measures;Medicaid eligibility;Medical History;Metabolic;Methods;Modeling;modifiable risk;Morbidity - disease rate;mortality;mortality risk;neighborhood disadvantage;Neighborhoods;Neurological outcome;Non-accidental;Obesity;older adult;Oxidative Stress Induction;Ozone;ozone exposure;Patients;Persons;Policies;pollutant;poor health outcome;Population;Populations at Risk;Poverty;Predisposition;Prevalence;Public Health;Pulmonary Emphysema;Race;Racial Segregation;Records;Research;residence;Resolution;respiratory;Respiratory Disease;response;Risk;Risk Assessment;Risk Factors;Role;sex;Smoking Behavior;Smoking Status;social vulnerability;sociodemographics;spatiotemporal;Stroke;Testing;Time;United States;Veterans;Veterans Health Administration;vulnerable community;Vulnerable Populations

PROJECT_TITLE: Air Pollution and Mortality Risk in Veterans with Chronic Respiratory Disease: Assessing the Role of Individual and Place-Based Risk Factors

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Pain Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Chronic musculoskeletal pain, while a leading cause of disablement, is a neglected national health disparity issue in Black communities; as a matter of fact, only 11% (median) of participants in NIH-sponsored chronic pain research were identified as Black/African American. Specifically, chronic musculoskeletal pain is primarily driven by movement-evoked pain which contributes to pronounced mobility limitations and disability in Black/African American older adults. Disrupting persistent patterns of disparity in this population demands novel culturally congruent self-management interventions that will advance health equity and attenuate the adverse economic, functional, and mental health consequences associated with chronic musculoskeletal pain.

PI_NAMEs: BOOKER, STAJA  (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Acute;Address;Adult;Affect;African American;African American population;Age;Analgesics;Area;Arthritis;Attenuated;Back;barrier to care;Behavior;behavior change;Black race;Caring;Characteristics;Chronic;chronic musculoskeletal pain;chronic pain;Clinical;Communities;community intervention;comparison intervention;Control Groups;coping;Coping Skills;cost;Counseling;culturally appropriate intervention;daily pain;design;disability;Disablement;Disabling;Disparity;Ecological momentary assessment;economic disparity;economic need;Economics;Education;Educational Materials;effective intervention;Effectiveness;efficacy evaluation;Elderly;Enrollment;evidence base;experience;Face;Faith;Family;Feasibility Studies;Financial Hardship;financial literacy;Funding;Gender;Health;Health Care Costs;health care service;health disparity;health disparity populations;health equity;Health Insurance;health literacy;Healthcare;Hip region structure;Hour;human old age (65+);Hyperalgesia;improved;Individual;Inequality;Inequity;innovation;Insurance;Insurance Benefits;Intervention;intervention effect;intervention refinement;Intervention Trial;Joints;Knee;Knowledge;Lead;Learning;literacy;Literature;Low income;Measures;Mediating;Mediator;Medicare;men;Mental Health;Mobility decline;Modeling;Movement;Musculoskeletal;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;neglect;Non-Steroidal Anti-Inflammatory Agents;novel;Nurses;older adult;opioid use;Outcome;Outcome Assessment;Pain;Pain intensity;Pain interference;Pain management;Pain quality;pain reduction;pain relief;Pain Research;pain self-management;Participant;Pattern;perceived stress;Persons;Physical Function;Physical Performance;Population;post intervention;Poverty;Practice Management;Prayers;preference;primary endpoint;primary outcome;Professional counselor;prototype;psychosocial;Psychosocial Factor;Race;racial disparity;racial minority;Randomized, Controlled Trials;Reporting;Research;Resources;Rest;secondary outcome;Self Management;Seminal;Severities;sex;sex as a biological variable;Single-Blind Study;skills;smart watch;social culture;social health determinants;Societies;socioeconomics;Source;Spirituality;Technology;Telephone;Testing;Time;Tissues;Training;United States National Institutes of Health;usual care arm;Veterans;Walking;Woman;Work

PROJECT_TITLE: Testing the Pain Relief of musculOskeletal conditions and Arthritis using Culturally Tailored InterVentions for Black Elders (PROACTIVE) Intervention: A Randomized Controlled Trial

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Brain Disorders;Congenital Muscular Dystrophy;Congenital Structural Anomalies;Intellectual and Developmental Disabilities (IDD);Muscular Dystrophy;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: RENO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Project Narrative Laminin-2 related congenital muscular dystrophy (LAMA2-CMD) is a fatal neuromuscular disease for which there is no cure or approved treatments. This study will provide new mechanistic insights into the role laminin isoforms play in regulating muscle adhesion-signaling complexes, remodeling the extracellular matrix, restoring muscle repair and neuromuscular function. These studies will provide mechanistic insights into the role laminin isoforms play in skeletal muscle structure and function.

PI_NAMEs: BURKIN, DEAN J. (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Adhesions;Adult;Age;Axon;Basal lamina;Basement membrane;Biological;Biological Assay;biomarker identification;Birth;canine model;Cell Line;Complex;congenital muscular dystrophy;Data;Defect;Development;Diameter;digital;Direct Lytic Factors;Disease Progression;Distal;Duchenne muscular dystrophy;effective therapy;Embryo;Engraftment;Enteral Feeding;enzyme replacement therapy;Exhibits;Extracellular Matrix;Extracellular Matrix Proteins;functional loss;functional restoration;Genes;Goals;Growth;Human;Immune response;Immunohistochemistry;Impairment;improved;in vitro Assay;insight;Kidney;Kyphosis deformity of spine;Laminin;laminin alpha 2;Life;Life Expectancy;Measures;Merosin-Deficient Congenital Muscular Dystrophy 1A;Microscopy;Modeling;Molecular;Motor Neurons;mouse model;Mus;Muscle;Muscle Cells;Muscle Development;Muscle function;muscle regeneration;muscle repair;Muscle satellite cell;muscle strength;Muscle Weakness;Muscular Atrophy;muscular structure;Mutation;Myelin;myelination;Myoblasts;myogenesis;Myopathy;Nerve;Neural Conduction;Neuromuscular Diseases;neuromuscular function;Onset of illness;Pathology;Patients;Peripheral Nerves;Play;pre-clinical;premature;programs;Protein Isoforms;Proteins;Receptor Cell;Recombinants;repair function;repaired;Resolution;Respiratory Insufficiency;Role;Schwann Cells;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle growth;Spinal nerve root structure;superresolution microscopy;Testing;Thick;Transmission Electron Microscopy;Ventilator

PROJECT_TITLE: Laminin protein therapy for the treatment of Laminin-alpha2 deficient congenital muscular dystrophy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-D (05)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Inflammatory Bowel Disease;Prevention

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE Surveillance for pre-cancerous dysplasia with colonoscopy is standard of care for patients with long standing inflammatory bowel disease. While guidelines for surveillance colonoscopy have typically included recommendations to obtain four untargeted random biopsies every 10 cm throughout the colon along with targeted biopsies of abnormal appearing lesions, the utility of this approach has been questioned. This pragmatic randomized clinical trial titled “Utility of Random Biopsies in Inflammatory Bowel Disease (URBI)” will test whether a limited biopsy strategy obtaining two random biopsies from two locations is non-inferior to obtaining four random biopsies every 10 cm to detect dysplasia and will support translational research exploring the molecular changes that evolve during the progression from inflammation to high-grade dysplasia.

PI_NAMEs: KAESTNER, KLAUS H;LEWIS, JAMES D (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Acute;Address;Agreement;Anesthesia procedures;Biological;Biology;Biopsy;Biopsy Specimen;Categories;Characteristics;chromoscopy;Chronic;Classification;Clinical;Clinical Data;Clinical Trials;Colitis;Colon;Colonic Diseases;Colonoscopy;Colorectal Cancer;colorectal cancer risk;cost;Crohn's disease;Detection;Diagnosis;Dysplasia;efficacy testing;Equipoise;follow-up;Gene Expression Profile;Guidelines;Hemorrhage;High grade dysplasia;Imaging Techniques;improved;Inferior;Inflammation;Inflammatory Bowel Diseases;instrument;Label;Lesion;Light;Link;Location;Microscopic;Modernization;Molecular;Molecular Biology;molecular imaging;Morbidity - disease rate;mortality;Mucous Membrane;Optics;Outcome;Pathologic;Pathologist;Patient Care;Patient Schedules;Patients;Perforation;Phenotype;premalignant;primary outcome;Procedures;Professional Organizations;Provider;Randomized;randomized, clinical trials;Recommendation;Research;Resected;Residual state;Resources;Respondent;Risk;Serrated Adenoma;Specimen;standard of care;Surveys;Technology;Testing;Time;Tissues;transcriptomics;Translational Research;Ulcerative Colitis;Uncertainty;United States;virtual;Visualization

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-Q (J2)]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Pediatric;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Bipolar disorder typically begins in adolescence; recurrent mood symptoms during this period can have a devastating impact on a person's ability to achieve a high quality of life. Digital phenotyping, defined as the “moment-by-moment quantification of the human phenotype in situ” using data collected from smartphone sensors, may make it possible to better understand and predict the onset of mood symptoms with minimal burden to the individual. The goal of this K23 proposal is to characterize the digital phenotype of bipolar disorder in adolescents in order to prospectively predict mood symptoms, creating an opportunity to reduce the harmful effects of recurrent episodes.

PI_NAMEs: VAN METER, ANNA ROBINSON (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Accelerometer;Adolescence;Adolescent;Adult;aged;Android;Award;Behavior;Bipolar Disorder;career;Caregivers;Cellular Phone;computer science;Data;Development;digital phenotyping;Doctor of Philosophy;emerging adult;Exposure to;follow-up;Future;Goals;higher education;Human;improved;In Situ;Individual;innovation;Intervention;Interview;Learning;Link;longitudinal analysis;Longitudinal Studies;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;meter;Methods;mobile computing;mood symptom;Moods;Morbidity - disease rate;mortality;National Institute of Mental Health;new technology;novel strategies;Occupations;Participant;patient oriented;patient oriented research;Patients;Persons;Phenotype;Population;predictive modeling;programs;prospective;Psychiatry;Quality of life;Recurrence;Relapse;Research;Research Design;Research Personnel;Risk;sensor;skills;smartphone application;Specific qualifier value;statistical and machine learning;Symptoms;Techniques;Technology;Telephone;Training;Translational Research;Youth

PROJECT_TITLE: The Digital Phenotype of Bipolar Disorder: Harnessing Technology to Identify Bipolar Mood Symptoms - Revision - 1

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Prevention;Sleep Research

PHR: Project Narrative Insomnia places a significant burden on public health due to its high prevalence and negative impact on a wide range of health-related domains. However, we have limited understanding of how insomnia should be defined and whether there are different subtypes, which impairs our ability to prevent and treat this common sleep disorder. This study will conduct the most comprehensive re-evaluation to date of the classification of insomnia in order to guide future diagnosis, prevention and treatment.

PI_NAMEs: GEHRMAN, PHILIP RICHARD (contact)

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: actigraphy;Address;Adult;Age;Anxiety;Categories;circadian;Circadian desynchrony;Classification;Clinical;Clinical assessments;clinical diagnosis;clinical practice;Cognitive;Communities;daily functioning;Data;Detection;Diagnosis;Diagnostic;diagnostic criteria;Diagnostics Research;diaries;Dimensions;Disease;Distress;Electroencephalography;Equation;Etiology;Evaluation;Functional disorder;Future;Goals;Health;health care service utilization;heart rate variability;Heterogeneity;High Prevalence;Home;Impairment;Individual;Inflammation;Knowledge;Lead;Light;Measures;Melatonin;Mental Depression;Mental Health;Modeling;Neurocognitive;Outcome;Patient Self-Report;Patients;Pattern;Performance;Periodicity;Peripheral;Phase;Phenotype;Physiological;Polysomnography;precision medicine;prevent;Prevention;Productivity;Provider;Public Health;Quality of life;recruit;Reporting;Research;Risk Factors;Science;screening;Self Management;sex variable;Sleep;Sleep Apnea Syndromes;Sleep Disorders;sleep onset;Sleeplessness;Solid;Strategic Planning;Subgroup;Symptoms;System;Testing;Time;Validity and Reliability;Visit;Wakefulness;Woman;Work

PROJECT_TITLE: Redefining Insomnia: A Comparison of Categorical and Dimensional Approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-N (02)]


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The inflammation and degeneration of the aortic artery can lead to life-threatening rupture and unfortunately, there is no medical therapy available to prevent this from happening. Our biologist/engineer/surgeon team will perform research to better understand the molecular and cellular underpinning of the disease and in parallel develop targeted drug delivery so that clinically viable therapies could result sooner.

PI_NAMEs: GONG, SHAOQIN -;GUO, LIANWANG  (contact);KENT, K CRAIG;MCNAMARA, COLEEN A

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Abdominal Aortic Aneurysm;Aneurysm;Aorta;Arteries;ATAC-seq;Automobile Driving;Binding;Biochemical;Biodistribution;biomaterial compatibility;Biomimetics;Blood Platelets;Blood Vessels;Bromodomain;CCAAT-enhancer-binding protein-delta;Cell Death;Cell Nucleus;Cells;ChIP-seq;Chromatin;Clinical;cytokine;Data;Development;Disease;Drug Delivery Systems;Drug Targeting;efficacy evaluation;Elastases;Encapsulated;Endothelial Cells;Engineering;Enhancers;Epigenetic Process;epigenome editing;Exposure to;Functional disorder;Gene Activation;Gene Expression;Genes;Genetic Transcription;genome-wide analysis;Histone Acetylation;Homing;Human;Immune;improved;Inflammation;Inflammatory;inhibitor;Injectable;insight;knock-down;Knock-out;Knockout Mice;Lentivirus;Lesion;Life;Mediating;Medical;Medicine;Membrane;Metalloproteases;Methods;Modeling;Molecular;Molecular Target;mortality;mouse model;Mus;nanoparticle;nanotechnology platform;novel;novel therapeutic intervention;overexpression;Peptide Hydrolases;Pharmaceutical Preparations;Physiological;Play;prevent;protein expression;Proteins;Proteolysis;Research;Resistance;Resistance development;Role;Rupture;Severities;Signal Transduction;Site;Smooth Muscle Myocytes;Sudden Death;Surgeon;targeted delivery;TNF gene;Transcription Coactivator;transcription factor;Vascular Smooth Muscle

PROJECT_TITLE: Targeted approach to the mitigation of abdominal aortic aneurysm

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-D (02)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Over 3 million people in the United States suffer from epilepsy, which is a serious disease that in many cases cannot be effectively treated with medications or brain surgery. The goal of this project is to develop and test a powerful new processor and supporting software to analyze brain signals in a brain implantable neuromodulation device for epilepsy. We believe this project will result in both an improved understanding of epilepsy and improved therapy for epilepsy and is thus highly relevant to the NINDS mission to reduce the burden of neurological disease.

PI_NAMEs: BHATTACHARJEE, ABHISHEK ;MANOHAR, RAJIT  (contact);SPENCER, DENNIS D;ZAVERI, HITTEN P

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Algorithms;analog;Animals;Anticonvulsants;Anxiety;Applications Grants;Benchmarking;Biomedical Engineering;Brain;Brain region;brain surgery;Budgets;Cessation of life;clinical translation;Cognition Disorders;comorbidity;Computer software;Computers;Computing Methodologies;Data;Data Science;deep learning;design;Detection;Development;Devices;Diagnosis;digital;digital solutions;Disease;Electric Stimulation;Electroencephalography;Elements;Engineering;Epilepsy;Epileptogenesis;Evaluation;Excision;experience;feature detection;Feedback;flexibility;Goals;Human;Implant;implantable device;improved;in vivo evaluation;Incidence;innovation;Instruction;Intractable Epilepsy;Knowledge;Language;Libraries;Location;Machine Learning;machine learning method;Measures;Medical;Mental Depression;Mental disorders;Methodology;Methods;Mission;Modeling;Modernization;Monitor;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neural implant;neuropsychiatric disorder;neuroregulation;Neurosciences Research;open source;Operative Surgical Procedures;Outcome;Partial Epilepsies;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Population;Prevention;programs;Pythons;real time monitoring;Recurrence;Refractory;Research;Research Project Grants;Rodent Model;Seizures;signal processing;Signal Transduction;Stream;Techniques;Testing;theories;Time;translational applications;United States;United States National Institutes of Health;vector;Work

PROJECT_TITLE: A flexible, low power, multi-channel, real-time BCI for seizure monitoring and Modulation

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: FORT COLLINS

ORG_DEPT: BIOLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Adaptation to high elevation environments protects against hypoxia-related pregnancy complications. Studying how these genetically-based adaptations influence placental responses to hypoxia offers an opportunity to improve our understanding of both the fundamentals of placental development and the origins of obstetric diseases in humans. With these broad goals in mind, the present proposal uses a model system for high- elevation adaptation, the deer mouse, to identify transcriptional variation that shapes placental development and protects fetal development under chronic hypoxia.

PI_NAMEs: WILSTERMAN, KATHRYN  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Acclimatization;Address;Adverse effects;adverse pregnancy outcome;Alleles;Andean;ATAC-seq;Biological Models;Biology;Candidate Disease Gene;Cell Nucleus;cell type;Cells;Chromatin;Chronic;Data;Deer Mouse;Development;Developmental Process;Discipline of obstetrics;Disease;Environment;experience;experimental study;fetal;Fetal Development;Fetal Growth;Fetal Growth Retardation;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene network;Generations;Genetic;Genetic Processes;Genetic Transcription;genetic variant;Genetic Variation;genome sequencing;gestational hypoxia;Goals;Haplotypes;Health;Histologic;Histology;Human;Hybrids;Hypoxia;improved;In Vitro;in vivo;Individual;innovation;Labyrinth;Link;Mammals;Maternal-Fetal Exchange;Mediating;Molecular and Cellular Biology;Molecular Conformation;multiple omics;Mus;normoxia;Outcome;Pattern;Peromyscus;Physiological;Physiological Processes;Physiology;Placenta;Placentation;Play;Population;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy Complications;Premature Birth;prevent;Primary Cell Cultures;Process;protein function;Quechua;Regulation;Research;resilience;response;Risk;Role;Shapes;single nucleus RNA-sequencing;Structure;Surface;System;Tissues;transcriptome;transcriptome sequencing;Variant;whole genome

PROJECT_TITLE: The physiological and genetic basis of gestational adaptations to hypoxia

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Clinical Research;Precision Medicine;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE While it is established that a subgroup of patients with idiopathic inflammatory myopathies (IIM) are diagnosed with contemporaneous cancer, the ability to predict cancer at the patient-level is imperfect. This proposal will develop and externally validate the first predictive tool to determine cancer risk and guide clinical decision- making in IIM patients (Aim 1). In Aim 2, the relationship between cancer emergence, cancer elimination, and IIM outcomes will be determined using novel liquid biopsy cancer detection technologies, providing insights into novel IIM treatment strategies and improvements in disease monitoring.

PI_NAMEs: MECOLI, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Antibodies;Autoantibodies;Autoimmunity;Biological;Biological Markers;Cancer Detection;cancer diagnosis;Cancer Remission;cancer risk;cancer site;carcinogenesis;chronic autoimmune disease;Chronic disability;Clinical;clinical decision-making;clinical remission;cohort;Cohort Studies;cost;Data;Death Rate;Development;Diagnosis;Disease;Disease remission;effective therapy;Enrollment;Equilibrium;General Population;Goals;high risk;Idiopathic Inflammatory Myopathies;illness length;Immunosuppression;improved;individual patient;Inflammatory;insight;Knowledge;liquid biopsy;Malignant Neoplasms;Measures;Methods;Minority;Monitor;Muscle Weakness;Myositis;neglect;Newly Diagnosed;novel;Oncology;Onset of illness;Outcome;Pathogenesis;patient subsets;Patients;Population;Predictive Cancer Model;predictive tools;prospective;Prospective, cohort study;Pulmonary Fibrosis;Radiation;Reporting;Research;response;Risk;risk stratification;Screening for cancer;SEER Program;Site;standard of care;Standardization;Subgroup;Technology;tool;transcriptional intermediary factor 1;Treatment Protocols;treatment strategy;tumor DNA;United States;Universities;Validation;web portal

PROJECT_TITLE: Prediction and Significance of Cancer in Idiopathic Inflammatory Myositis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Nanotechnology

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: NARRATIVE. As demonstrated by the utilization of nanoparticles for vaccine delivery during the COVID-19 pandemic, nanomedicine has the potential to transform human health. However, nanomedicine is yet to reach its full potential in several diseases, partly due to our inability to tailor nanoparticle delivery to regions of interest and the potential toxicity associated with nanoparticle accumulation in off-target locations. To overcome these challenges, we propose to use artificial intelligence, mathematical modeling, and animal experiments to generate guidelines for rational design of nanoparticles for improved clinical outcomes.

PI_NAMEs: DOGRA, PRASHANT  (contact);NOUREDDINE, ACHRAF

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Acceleration;Adoption;Animal Experiments;Animal Testing;Artificial Intelligence;artificial intelligence method;artificial intelligence model;Biodistribution;Biological;Blood Cells;Blood Vessels;Chemistry;Classification;Clinical;clinical translation;cohort;COVID-19 pandemic;Data;Data Set;design;Development;Diffusion;digital twin;Disease;diverse data;Dose;Drug Delivery Systems;Drug Kinetics;Drug Targeting;Endothelium;Environment;Excretory function;explainable artificial intelligence;feature selection;first-in-human;Formulation;Generations;generative models;Guidelines;Health;Hepatobiliary;Human;Immune;improved;In Vitro;in vivo;innovation;interest;Investigation;Kidney;Kinetics;Literature;Liver;Location;Machine Learning;materials science;mathematical model;Mathematics;Mediating;Medical;Medicine;Modeling;models and simulation;Mononuclear;multi-scale modeling;multidisciplinary;Mus;nano;nanomaterials;nanomedicine;nanoparticle;nanoparticle delivery;nanoscience;nanotoxicity;novel;off-target site;open source;Organ;Outcome;PET/CT scan;Phagocytes;pharmacokinetic model;Physiological;Plasma Proteins;pre-clinical;preclinical development;predictive modeling;Property;rational design;Rationalization;Research;research and development;Route;Safety;Science;Shapes;Site;Solid Neoplasm;Spleen;Structure;Surface;synthetic data;System;Testing;Tissues;Toxic effect;Toxicology;training data;vaccine delivery;Validation;virtual animals;web-based tool;Work;X-Ray Computed Tomography;zeta potential

PROJECT_TITLE: Artificial intelligence-integrated mechanistic modeling for rational design of nanoparticles to improve organ targeting and safety

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Wound Healing and Care

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative A novel drug delivery platform will be studied for local, sustained growth factor delivery. Its success will lead to a paradigm shift in the development of drug delivery systems for the treatment of various human diseases such as tissue loss or damage.

PI_NAMEs: WANG, YONG  (contact)

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: Affinity;angiogenesis;Animal Model;aptamer;Area;Binding;Biocompatible Materials;Biodegradation;bioimaging;Biological Assay;Biomanufacturing;Biomedical Engineering;Biosensing Techniques;Cells;cellular engineering;chemical conjugate;Clinical;Collagen;Collagen Fiber;density;design;Development;Drug Delivery Systems;drug development;Engineering;Exhibits;FGF2 gene;Goals;Growth;Growth Factor;human disease;in vivo;Infiltration;innovation;Kinetics;Lead;Malignant Neoplasms;manufacture;Mediating;Methods;Modeling;Mole the mammal;molecular recognition;novel;novel therapeutics;Operative Surgical Procedures;Patients;Pharmaceutical Preparations;platelet-derived growth factor BB;Procedures;Property;Regenerative Medicine;release factor;Research;Scheme;Specificity;Subcutaneous Injections;success;synergism;System;technology platform;Testing;Tissues;Toxic effect;Treatment Efficacy;Vascular Endothelial Growth Factors;wound;wound closure;wound healing;Wound models

PROJECT_TITLE: Non-covalent functionalization of collagen for growth factor delivery using bispecific aptamers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (81)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Disability Research;Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Traditional rehabilitation approaches are time and personnel intensive and costly, and leave ~75% of stroke survivors with residual disability. We propose a clinical trial to determine effects of forced aerobic exercise (FE; i.e., mechanically supplemented) in facilitating upper and lower extremity motor recovery post-stroke in an outpatient rehabilitation setting, to elucidate neural and biochemical substrates of FE-induced motor recovery, and to evaluate cost effectiveness of a FE-centered intervention compared to traditional stroke rehabilitation. The global effect of FE has the potential to enhance recovery in a growing population of stroke survivors in a cost-effective manner, thus accelerating its clinical acceptance.

PI_NAMEs: LINDER, SUSAN MARIE (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: 3-Dimensional;Abbreviations;Acceleration;Action Research;Adopted;Aerobic;Aerobic Exercise;Animals;Area;arm;Biochemical;Biochemical Markers;Biological Markers;biomechanical test;Brain;Brain Injuries;Brain-Derived Neurotrophic Factor;Cardiovascular Physiology;Central Nervous System;Clinical;clinical care;Clinical Trials;comparison intervention;cost;cost effective;cost effectiveness;cost estimate;cost-effectiveness evaluation;cost-effectiveness ratio;Coupled;Data;dexterity;disability;Doctor of Philosophy;Dose;economic value;Effectiveness;Electroencephalography;Electrophysiology (science);Exercise;exercise intensity;Exhibits;experience;Gait;Goals;grasp;Growth Factor;hemiparesis;Human Resources;improved;incremental cost-effectiveness;Individual;Insulin-Like Growth Factor I;Intervention;kinematics;Kinetics;Lower Extremity;Manuals;Measures;Mechanics;Methods;Modeling;Motion;Motor;motor impairment;motor learning;motor recovery;Movement;multidisciplinary;Nervous System Physiology;neural;Neurologic;Neuronal Plasticity;Occupational Therapy;older adult;Outpatients;Patients;Pattern;Peripheral;Persons;Physiatrist;physical therapist;Physical therapy;Population;post stroke;Pragmatic clinical trial;primary outcome;prospective;Protocols documentation;Randomized;Recovery;Rehabilitation therapy;Residual state;response;secondary outcome;spatiotemporal;Stroke;stroke rehabilitation;stroke survivor;Testing;theories;Time;Torque;Training;treatment as usual;Uncertainty;Upper Extremity;Walking

PROJECT_TITLE: The I-SCORE (Intensive Stroke Cycling for Optimal Recovery and Economic value) Trial

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ORG_NAME: DANA-FARBER CANCER INST

PHR: Despite recent advances in understanding the genomic landscape of bladder cancer, the median survival for advanced bladder cancer patients is only 14 months; therefore, there is an urgent need to develop new therapeutic approaches to improve clinical outcomes. A subset of bladder tumors harbor alterations in the mitogen-activated protein kinase (MAPK) and peroxisome proliferator activated receptor gamma (PPARG) pathways, and we hypothesize that MAPK signaling drives a PPARG-mediated luminal-like, immune-excluded bladder cancer phenotype. Using genetically annotated patient-derived and immune-competent preclinical bladder cancer models, we will functionally dissect the molecular interplay between MAPK and PPARG signaling, define the role of MAPK pathway activity on the PPARG-mediated immune-excluded phenotype, and investigate the activity of co-targeting MAPK and immune checkpoint signaling in bladder cancer.

PI_NAMEs: MOUW, KENT W (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Address;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;Binding;Biology;Bladder Neoplasm;blood glucose regulation;Cancer Biology;cancer cell;Cancer cell line;cancer diagnosis;Cancer Model;Cancer Patient;Cell Differentiation process;cell type;Cells;Cessation of life;checkpoint inhibition;Chromosome Mapping;Clinical;cohort;cytokine;Cytokine Gene;Cytokine Signaling;Data;Dimerization;DNA Sequence Alteration;Exclusion;Gene Expression;Genetic Transcription;genomic data;Genomics;Glucose;Homeostasis;Human;Immune;immune cell infiltrate;immune checkpoint;Immune Tolerance;Immunocompetent;improved;improved outcome;inhibitor;Lipids;Macrophage;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Measures;Mediating;MEKs;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinases;Modeling;Molecular;Mus;mutant;Mutation;neoplastic cell;NF-kappa B;novel;novel therapeutic intervention;Nuclear Receptors;Oncogenic;Outcome;paracrine;Pathway interactions;Patients;Phenotype;Phosphorylation;PPAR gamma;pre-clinical;programs;Property;RAF1 gene;RAS genes;response;restraint;Role;RXRA gene;Shapes;Signal Transduction;targeted treatment;Testing;Therapeutic;Therapeutic Effect;transcription factor;Translating;treatment effect;Treatment outcome;tumor;tumor growth;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;Urothelial Cell;Work

PROJECT_TITLE: Dissecting and Targeting MAPK - PPARG Crosstalk in Bladder Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: The validation of breast-specific treatment planning, monitoring and assessment techniques will accelerate translation of a magnetic resonance-guided focused ultrasound system towards the efficient, non-invasive treatment of localized breast cancer. Incorporation of validated techniques in a clinic-ready planning, monitoring and assessment software package will enable a feasibility clinical trial to verify this non-invasive therapy can achieve efficacy within acceptable safety limits.

PI_NAMEs: PAYNE, ALLISON  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Ablation;Acceleration;Algorithms;Alprostadil;Applications Grants;aqueous;Breast;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;Breast conservation;Breast Diseases;Cicatrix;clinic ready;Clinical;clinical translation;Clinical Treatment;Clinical Trials;Collaborations;Computer software;cost;Data;Early treatment;Ensure;Environment;experience;Fatty acid glycerol esters;Fiber Optics;Focused Ultrasound;Functional impairment;Gadolinium;high resolution imaging;Histology;Histopathology;Hybrids;Image;image guided;image guided therapy;Immunohistochemistry;improved;in vivo;in vivo Model;Industrialization;Industry;industry partner;Infection;innovation;Institution;Intervention;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Measurement;Methodology;Methods;minimally invasive;Modeling;Monitor;Morbidity - disease rate;necrotic tissue;non-invasive system;novel;Operative Surgical Procedures;parent grant;Patients;Phase;Phase I Clinical Trials;Planning Techniques;pre-clinical;preclinical evaluation;Procedures;Process;Protocols documentation;prototype;psychological distress;real time monitoring;Recovery;Research Personnel;Resected;Resources;Safety;safety assessment;Scanning;Scientist;simulation;Site;System;Techniques;Technology;Temperature;Thermometry;Time;Tissues;tool;Translating;Translations;treatment planning;tumor;ultrasound;Universities;Utah;Validation;Work

PROJECT_TITLE: Validation and translation of a non-invasive, MR-guided breast cancer therapy


NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Genetics;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

PHR: PROJECT NARRATIVE There is a need to uncover the etiological mechanisms underlying the association between preterm birth and impaired neurodevelopment, both to improve the identification of the preterm infants who are at higher risk for impaired neurodevelopment and to inform efforts towards neurodevelopmental interventions. This project will provide much needed data to pave the way for novel opportunities for neurodevelopmental prevention and intervention efforts for preterm infants, and thus, decrease the incidence of neurodevelopmental disabilities and morbidities.

PI_NAMEs: MOMANY, ALLISON MARIE (contact)

PROGRAM_OFFICER_NAME: MACHLIN, LAURA STONER

PROJECT_TERMS: 2 year old;37 weeks gestation;Affect;Age;Biological;biological adaptation to stress;Birth;Blood Pressure;Buffers;career;caregiver stress;Caregivers;Child;Clinic;Clinical;Clinical Nursing Research;Complex;Data;Development;Developmental Process;Distress;DNA Methylation;early childhood;economic cost;Educational workshop;effective intervention;Environment;Epigenetic Process;Etiology;experience;extreme prematurity;Faculty;follow-up;Future;Genes;genetic analysis;Gestational Age;Goals;Heart Rate;high risk;high risk infant;Hospitalization;Human;Human Genetics;Hydrocortisone;Hydroxyprogesterone;Impairment;improved;Incidence;indexing;infancy;Infant;Infrastructure;Institution;Intervention;Investigation;Iowa;Knowledge;laboratory experience;Lead;Level of Evidence;Life;Link;Literature;longitudinal analysis;Measures;Mediating;member;Mentors;Mentorship;Methods;Modification;Molecular Genetics;Morbidity - disease rate;National Institute of Child Health and Human Development;neglect;Neonatal;neonatal morbidity;Neonatology;neurodevelopment;Neurodevelopmental Deficit;Neurodevelopmental Disability;Neurodevelopmental Disorder;novel;Outcome;Oxygen;Physiological;Physiology;premature;Premature Birth;Premature Infant;Prevention;Procedures;professor;programs;psychological distress;Research;Research Personnel;research study;Research Support;Risk;Risk Factors;Sampling;Scientist;Severities;skill acquisition;skills;Statistical Models;Strategic Planning;Stress;success;tenure track;Training;Training and Education;Translating;United States;Universities;Variant

PROJECT_TITLE: Neonatal Stress in Very Preterm Infants:  Longitudinal Effects on Epigenetics and Neurodevelopment

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: NARRATIVE Aging is the major risk factor for human pathologies that lead to disease, morbidity and mortality. Therefore, a better understanding of aging and the processes that affect lifespan at the molecular level remains an important problem in modern biology and medicine. The goals of this project are to better understand one of the potential drivers of aging.

PI_NAMEs: MARR, MICHAEL THOMAS (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;Affect;Age;age effect;age related;age related changes;age-related disease;Aging;aging related;animal old age;Biological Models;Biology;Bystander Effect;Cell Physiology;cell type;Cells;Cellular Stress;Complement;Complex;Disease;DNA;DNA Damage;DNA Transposable Elements;drivers of aging;Drosophila genus;Elements;Engineering;Excision;extend lifespan;fly;Gene Expression;Genes;Genetic;genetic element;Genetic Engineering;Genome;genome integrity;Genomics;Genotype;Goals;Heterochromatin;Homeostasis;Hot Spot;Human;Human Pathology;Intervention;Isoptera;juvenile animal;life span;Longevity;Medicine;Messenger RNA;Mobile Genetic Elements;Modeling;Modernization;Molecular;Morbidity - disease rate;mortality;Movement;mRNA Expression;mRNA sequencing;Organism;Oxidative Stress;Pathogenesis;Pathway interactions;Phase;Phenotype;Physiological;preference;Process;Proteins;proteostasis;proteostasis loss;Recording of previous events;response;Retrotransposon;Risk Factors;RNA-Directed DNA Polymerase;Rodent;Role;Siblings;Site;Specificity;System;Taxes;Testing;Tissues;tool;transcription factor;transcriptome;Translations;Work

PROJECT_TITLE: Genetic and genomic effects of increased transposition

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Organ Transplantation;Prevention;Transplantation;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative We will use preclinical mouse models to define the mechanisms underlying humoral sensitization by semi- allogeneic pregnancy, and to investigate how this sensitization overrides pregnancy-induced and co-stimulation blockade-induced long-term acceptance of offspring-matched heart grafts. The long-term goal of this project is to improve access to transplantation in historically-disadvantaged multiparous women, as well as to optimize their post-transplant outcomes through the prevention and reversal of pregnancy-induced humoral sensitization.

PI_NAMEs: CHONG, ANITA S (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: access disparities;Address;Adult;Adult women;Allogenic;Allografting;Antibodies;Antibody Response;antibody-mediated rejection;B-Lymphocytes;Binding;Blood Transfusion;C57BL/6 Mouse;CD4 Positive T Lymphocytes;Cells;Clinic;Clinical;desensitization;Disadvantaged;embryo/fetus antigen;Endothelial Cells;Equilibrium;Equitable healthcare;Event;Female;Fetus;Genes;Goals;Graft Rejection;Heart;Heart Transplantation;Helper-Inducer T-Lymphocyte;Humoral Immunities;humoral sensitization;Immunization;Immunoglobulin G;Immunoglobulin-Secreting Cells;Immunologic Memory;Improve Access;improved;improved outcome;Inbred BALB C Mice;Knowledge;male;Mediating;Mothers;mouse model;Mus;neonate;offspring;Organ Transplantation;Outcome;parous;Partner in relationship;pathogen;Patients;post pregnancy;post-transplant;Postpartum Period;pre-clinical;Pregnancy;preservation;prevent;Prevention;Production;Quality of life;Reporting;Research;Resistance;response;sex disparity;Spleen;success;synergism;T-Lymphocyte;Testing;theories;Transplantation;Transplantation Tolerance;Woman

PROJECT_TITLE: Mechanistic studies on pregnancy-induced humoral sensitization in organ transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Radiation Oncology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: COLLEGE STATION

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Project narrative Radiotherapy for head and neck cancer commonly results in the irreversible and severe decrease of saliva secretion that impairs the quality of life of patients remarkably. The goals of this proposal are to determine novel mechanisms of this side effect related to local macrophages and to develop corresponding approaches for restoring radiotherapy- damaged salivary gland function. The success of proposed studies will improve the recovery of saliva secretion and consequent quality of life in head and neck cancer patients treated with radiotherapy.

PI_NAMEs: LIU, FEI  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Address;Adult;Affect;Anti-Inflammatory Agents;Binding;cell injury;cell type;Cells;Cessation of life;Complement 1q;cytokine;Dendrites;Development;Duct (organ) structure;Embryo;Endothelial Cells;Epithelial Cells;epithelial stem cell;Feasibility Studies;Functional Regeneration;Gene Expression;Gene Transfer;gland development;Goals;Growth Factor;Hand;Head and Neck Cancer;head and neck cancer patient;Homeostasis;Immune response;Impairment;improved;Inflammation;Inflammatory;Infusion procedures;Interleukin-10;Interleukin-15;irradiation;Kinetics;Knock-out;Knowledge;Ligation;Lymphoid Cell;Macrophage;Maintenance;Membrane;Molecular;monocyte;Morphology;Mouse Strains;Mus;Natural regeneration;novel;novel strategies;novel therapeutics;Outcome;Outcomes Research;Oxidative Stress;paracrine;Patients;Phagocytes;Play;preservation;Quality of life;Radiation;Radiation induced damage;Radiation therapy;Reaction;Reagent;Recovery;Regenerative capacity;Research;restoration;Role;saliva secretion;Salivary;Salivary Glands;Scheme;self-renewal;sensor;Severities;side effect;Signal Transduction;Source;success;Technical Expertise;Testing;therapeutic target;Transgenic Mice;Work;Xerostomia

PROJECT_TITLE: Roles of resident macrophages in salivary gland development, homeostasis, regeneration, and function restoration after radiotherapy

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Rehabilitation;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: 8. PROJECT NARRATIVE This project proposes to investigate social cognition in a sample of Latinxs with a diagnosis of schizophrenia in order to better understand cross-cultural measurement and construct differences compared to white samples. This work will have implications for the development or adaptation of psychosocial interventions targeting social cognition in the Latinx/Hispanic population, promoting acceptability and engagement and reducing mental health service disparities in this population.

PI_NAMEs: FLORES, ANA TERESA (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Acculturation;Activities of Daily Living;Address;Affect;Age;Area;Asian;Attention;Black race;Characteristics;Clinical Trials;Cognition;Cognitive;Cognitive deficits;cognitive interview;cognitive process;cognitive rehabilitation;cognitive task;Cognitive Therapy;Communities;community engaged research;Competence;culturally appropriate intervention;Data;Data Analyses;Data Set;Development;Diagnosis;Disparity;Education;Emotional;Emotions;Ensure;Equity;ethnic minority;Ethnic Origin;Evaluation;Evaluation Studies;Evidence based treatment;experience;family support;functional improvement;functional outcomes;Gender;Goals;health care disparity;Hispanic Populations;Impairment;improved;Individual;innovation;Intervention;Interview;investigator training;Language;Language Development;Latinx;Latinx population;Measurement;Measures;Mental Health;Mental Health Services;Methodology;Methods;Modeling;National Institute of Mental Health;Neurocognition;Outcome;Participant;Pattern;peer;Perception;Population;preference;Process;Production;Property;Psychometrics;psychosocial;Race;rapid growth;Recovery of Function;recruit;Research;Research Methodology;Research Personnel;Research Training;response;Risk;Sampling;Schizophrenia;schizophrenia spectrum disorder;Science;Service delivery model;Services;social;social cognition;social culture;social influence;social skills;Social support;sociocultural determinant;Socioeconomic Status;Source;standard measure;Strategic Planning;Subgroup;symptomatology;Task Performances;Testing;theory of mind;Treatment Effectiveness;Underrepresented Populations;Underserved Population;Validation;Variant;Work

PROJECT_TITLE: Social Cognition in Latinx Individuals with Schizophrenia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F01A-V(20)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Regenerative Medicine

ORG_CITY: Fort Lauderdale-Davie

ORG_NAME: NOVA SOUTHEASTERN UNIVERSITY

PHR: Project narrative: One out of every two American adults aged 30 and over has periodontitis, which is an inflammatory bone lytic disease caused by poly-microbial infection around tooth. It is well documented that bone regeneration hardly ever occurs at the alveolar bone affected by periodontitis, even after the successful conventional periodontal treatment. Based on our preliminarily discovered finding, i.e., OC-STAMP molecule that specifically expressed by osteoclasts (bone resorbing cells) is engaged in not only bone resorption but also interruption of new bone regeneration, in the proposed RO1 project, we will gain more scientific insight into this finding for the development of novel non-invasive bone regenerative therapy for periodontitis and other bone lytic disease.

PI_NAMEs: KAWAI, TOSHIHISA  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Accounting;Activated Lymphocyte;Adult;Affect;Age;aged;alveolar bone;Alveolar Bone Loss;American;Anti-citrullinated peptide antibody;Bacteria;bone;bone loss;Bone Matrix;Bone Regeneration;Bone remodeling;Bone Resorption;CD100 antigen;Cell membrane;Cells;Characteristics;citrullinated protein;Coculture Techniques;Coupling;Defect;demineralization;Dendritic Cells;Development;Disease;Event;Excision;functional genomics;gain of function;Generations;Goals;Histocytochemistry;In Vitro;in vivo;in vivo imaging;Infection;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;Injections;insight;Integral Membrane Protein;Interruption;Knockout Mice;Ligand Binding;Ligands;Ligature;loss of function;Lytic;Mediating;Membrane;Messenger RNA;Molecular;Monoclonal Antibodies;monocyte;mouse model;multimodality;Mus;new therapeutic target;NIH 3T3 Cells;novel;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;osteogenic;osteoimmunology;overexpression;pathogen;Pathogenicity;Pathologic;Periodontitis;periodontopathogen;Persuasive Communication;Phenotype;Phosphorylation;Population;Porphyromonas gingivalis;Production;protein activation;Protein-arginine deiminase;Proteins;Publishing;receptor;regenerative therapy;release factor;Reporting;response;Role;Scientist;Signal Transduction;Site;skeletal;Small Interfering RNA;Somatomedins;Structure-Activity Relationship;Testing;Time;TNFSF11 gene;Tooth structure;transcriptome;transcriptome sequencing;Up-Regulation;vector;Vimentin

PROJECT_TITLE: Osteoimmunology of Retarded Bone Regeneration in Periodontitis


NIH_SPENDING_CATS: Autoimmune Disease;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Prevention

ORG_CITY: SAN ANTONIO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative Our studies are focused on characterizing the role of endogenous metabolites in inhibiting saliva secretion that leads to salivary gland dysfunctions. Elucidating the mechanism of lactate mediated inhibition of saliva secretion and immune cell activation; is important in elucidating new therapies for salivary gland dysfunctions.

PI_NAMEs: SINGH, BRIJ B (contact)

PROJECT_TERMS: Acinar Cell;Affect;age related;American;Autoantibodies;Autoimmune Diseases;Autoimmunity;B-Cell Activation;B-Lymphocytes;Back;Binding;Calcium;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Death;cell motility;Cell Physiology;Cells;Collaborations;cytokine;Dendritic Cells;Development;Disease;endoplasmic reticulum stress;Etiology;Event;Fatigue;Functional disorder;functional restoration;Grant;IL17 gene;Immune;immune activation;immune cell infiltrate;Immune response;Immune system;Immunophenotyping;immunoregulation;Inflammation;Inflammatory;insight;Lactation;lymphoid structures;Mediating;Metabolic;Metabolic Pathway;Metabolism;migration;Mitochondria;Molecular;mouse model;Movement;novel;novel therapeutics;Oral health;Oxidative Phosphorylation;Pathogenesis;Patients;Persons;Phenotype;Play;prevent;Production;Research;Role;Saliva;saliva secretion;Salivary;salivary acinar cell;Salivary Glands;Signal Transduction;Site;Sjogren's Syndrome;STIM1 gene;Stimulus;T cell differentiation;T-Cell Activation;T-Lymphocyte;Testing;therapeutically effective;Tissues;uptake;Waste Products

PROJECT_TITLE: Glycolytic metabolites, Calcium entry and Sjogren’s syndrome


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Disordered eating has been linked to poor cardiometabolic health, and cardiovascular disease and metabolic disorders are top causes of death in the United States. Weight stigma is a risk factor for disordered eating, and eating disorders are among the most lethal of mental disorders. Given that over 200 million individuals in the United States have a body mass index that puts them at risk for weight stigma, the potential public health impact of this work is significant.

PI_NAMEs: LEVINSON, JORDAN  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Address;Adolescent Development;Adult;Affect;American;Area;Attitude;Behavior;Behavioral;Belief;Binge Eating;Binge eating disorder;body dissatisfaction;Body Image;Body mass index;Buffers;cardiometabolism;Cardiovascular Diseases;career;Cause of Death;Classification;Cognitive;Control Groups;cost;Data;diaries;Discrimination;Eating Behavior;Eating Disorders;Educational workshop;Enrollment;Evidence based practice;experience;experimental group;Exposure to;Extramural Activities;Fellowship;Funding;Future;Goals;Grant;Growth;Health;high body mass index;Hyperinsulinism;Hypertension;Individual;Infrastructure;insight;Institution;Insulin Resistance;Intervention;Knowledge;Laboratories;laxative;Life;Link;Literature;Los Angeles;Measurement;Measures;meetings;Mental disorders;Mental Health;Mentors;Mentorship;Metabolic;Metabolic Diseases;Metabolic syndrome;Methodology;Methods;multidisciplinary;multilevel analysis;Nature;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Occupations;open data;Overweight;Parents;Participant;Patient Recruitments;Persons;Prejudice;prevent;Procedures;professor;Public Health;Randomized;Reporting;Research;Research Design;Research Personnel;resilience factor;Risk;Risk Factors;satisfaction;self esteem;skills;social;social expectations;social factors;social relationships;social stigma;Survey Methodology;Surveys;symposium;Symptoms;Testing;Thinness;Training;United States;Visit;Vomiting;Weight;Weight Gain;Weight maintenance regimen;Work;Writing

PROJECT_TITLE: The effect of weight stigma on daily disordered eating and potential resilience factors


NIH_SPENDING_CATS: Clinical Research;Data Science;Digestive Diseases;Dissemination and Implementation Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Social Determinants of Health

PHR: Project Narrative Diarrheal diseases are a leading cause of morbidity and mortality in children worldwide. The management of childhood diarrhea often depend on what type of pathogen is responsible, but in many cases testing is not affordable or feasible. We propose studies to develop and validate methods to make it easier for healthcare workers to decide how to treat children with diarrhea.

PI_NAMEs: LEUNG, DANIEL TED (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Accident and Emergency department;Accounting;Acute Diarrhea;Age;Ambulatory Care Facilities;Antibiotics;antimicrobial;Applied Research;Big Data;Blood;Breast Feeding;Canada;Caregivers;Cause of Death;Cessation of life;Child;Childhood;Climate;Clinic;Clinical;clinical application;clinical decision support;clinical development;clinical examination;Clinical Management;clinical predictive model;clinical predictors;Clinical Research;Cost Savings;Country;Data;Data Sources;design;Diagnostic;Diagnostic tests;diagnostic tool;Diarrhea;diarrheal disease;District Hospitals;economic evaluation;economic impact;Electronic Health Record;Electronics;Emergency Care;Emergency research;Enteral;ethnic diversity;Ethnic Population;Etiology;expectation;Feces;Feedback;Fever;Focus Groups;global health;Goals;Guidelines;Health care facility;health care service utilization;Health Personnel;Health system;Hydration status;implementation design;implementation study;improved;Income;Individual;Interview;Intrinsic factor;Laboratories;low and middle-income countries;low income country;Methods;Modeling;Morbidity - disease rate;mortality;Multi-site clinical study;Multicenter Studies;North America;pathogen;Patients;pediatric emergency;Performance;Physicians;Pilot Projects;Pollution;Population;Predictive Factor;predictive tools;Prevalence;Probability;Property;prospective;Recording of previous events;Resource-limited setting;Resources;respiratory;Risk Factors;rural setting;Sampling;Seasons;Site;smartphone application;support tools;Symptoms;Syndrome;Testing;tool;urban setting;urgent care;Viral;Vomiting;Weather

PROJECT_TITLE: Development of clinical decision tools for management of diarrhea of children in high and low resource settings

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ORG_CITY: BOSTON

ORG_STATE: MA

PHR: Project Narrative The proposed research is relevant to public health because BPDCN is a highly fatal yet understudied malignancy, in which there is no standard therapy and the mechanisms of dendritic cell transformation are not known. This project is relevant to the NIH's mission to gain fundamental knowledge to reduce illness because it will elucidate treatment strategies in BPDCN based on understanding of the genetic basis of the disease.

PI_NAMEs: LANE, ANDREW A (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Alleles;Apoptosis;Apoptotic;Area;BCL-2 Protein;BCL2 gene;Biological;Biological Assay;Biological Models;Biology;Blastic plasmacytoid dendritic cell neoplasm;Blood;Bone Marrow;Cancer Biology;cancer type;cell transformation;Cells;Chemoresistance;chemotherapy;Clinical;Clinical Research;Clinical Trials;clinically relevant;clinically significant;cohort;Complex;Confusion;Cutaneous Involvement;Data;Dendritic Cells;Dependence;Diagnosis;Diphtheria Toxin;Disease;DNA;DNA sequencing;effective therapy;exome;exome sequencing;Female;Frequencies;Functional disorder;Genes;Genetic;Genetic Engineering;Genetic Models;Genetic study;Genetic Transcription;GNB1 gene;Goals;Hematologic Neoplasms;Hematopoiesis;Heterotrimeric G Protein Subunit;Human;IL3RA gene;improved;improved outcome;in vivo;in vivo Model;Incidence;inhibitor;innovation;insight;Interleukins;Knowledge;Laboratories;Leukemic Cell;Leukemic Natural Killer Cell;loss of function mutation;lymph nodes;Lymphoma;male;Malignant - descriptor;Malignant Neoplasms;Measures;Medical;Medicine;mimetics;Mission;Modeling;mRNA Precursor;Mus;mutant;Mutate;Mutation;Names;Nature;NCAM1 gene;Neoplasms;novel;novel therapeutic intervention;Oncogenes;Ontology;optimal treatments;Orphan;Outcome;Output;Pathogenesis;patient derived xenograft model;Patients;Phenotype;premature;protective pathway;Public Health;Recurrence;Refractory;Relapse;Research;Resistance;RNA Splicing;Role;Sampling;sex;Sex Bias;Signal Transduction;Site;Somatic Mutation;Spliceosomes;standard care;stem cells;System;Targeted Resequencing;targeted sequencing;Testing;Therapeutic;Therapeutic Studies;therapeutic target;transcriptome;Transplantation;treatment response;treatment strategy;tumor;Tumor Suppressor Proteins;United States National Institutes of Health;Validation;women versus men;X Chromosome;X Inactivation

PROJECT_TITLE: Targeting blastic plasmacytoid dendritic cell neoplasm (BPDCN)

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric;Physical Activity;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: This project proposes to advance the opportunities for safe physical activity among people with Type 1 diabetes (T1D) by testing the efficacy three new promising approaches in a controlled setting—and then validating the resulting device in a real-world setting at home. The approaches will adjust insulin delivery in response to 1) real-time changes in insulin sensitivity, 2) the amount of “activity on board,” which acknowledges the influence of prior activity on future insulin needs, and 3) anticipated future physical activity based on past physical activity patterns. All of these will be tested as added modules in a fully- automated closed loop system (with resultant glycemia compared to the system without the modules) with a vision of providing the safe ability for physical activity in T1D without added user action.

PI_NAMEs: BRETON, MARC D (contact);DEBOER, MARK DANIEL

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Accelerometer;Accounting;actigraphy;Address;Algorithm Design;Algorithms;Anterior;Awareness;Behavioral;Blood Glucose;Carbohydrates;Clinical;Clinical Trials;Clinical Trials Design;comorbidity;Continuous Glucose Monitor;Cross-Over Studies;Cross-Over Trials;Data;Data Analyses;Databases;design;Development;Devices;diabetes management;Diabetes Mellitus;Dose;Double-Blind Method;efficacy testing;Engineering;Exercise;Fright;Future;Glucose;glycemic control;Goals;Hand;Health;Health Benefit;Home;Home environment;Hour;Hypertension;Hypoglycemia;improved;improved outcome;indexing;Individual;Infusion procedures;innovation;Insulin;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Intake;Life;Longevity;Measures;Mental Depression;Metabolic;Methods;Modeling;Neuropathy;novel;novel strategies;Obesity;Pattern;Pattern Recognition;Persons;Physical activity;Physiological;primary outcome;Randomized;Reaction;response;Retinal Diseases;Risk;risk mitigation;Risk Reduction;Safety;System;Technology;Testing;Time;trend;Update;Vision;Work

PROJECT_TITLE: Limiting Dysglycemia Around Physical Activity for People with Type 1 Diabetes Using Activity-Aware Automated Insulin Delivery – the APEX Project.

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: RELEVANCE TO PUBLIC HEALTH This project will develop new tools and study Wolbachia-mediated Plasmodium suppression in Anopheles mosquitoes, and how it can be influenced by a variety of field-relevant factors. The project will thereby assess the potential of using Wolbachia as a malaria control strategy.

PI_NAMEs: DIMOPOULOS, GEORGE ;XI, ZHIYONG  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Adult;Aedes;Africa;African;Anopheles Genus;Arboviruses;Area;Asian population;Bacteria;Biocontrols;Biological;Blood;Collaborations;cost;Culicidae;Cytoplasm;Data;Development;disorder control;Drug resistance;Effectiveness;Environment;Environmental Risk Factor;feeding;fitness;Frequencies;Generations;Genes;Genetic;genetic makeup;Genotype;High temperature of physical object;Human;human pathogen;Humidity;Immune;Infection;Inherited;Insecta;Insecticide Resistance;Invaded;Knowledge;life history;Malaria;Mediating;Meditation;Methods;Mosquito-borne infectious disease;Mus;novel;nutrition;Oxidation-Reduction;Parasite resistance;Parasites;pathogen;permissiveness;Plasmodium;Plasmodium falciparum;Population;population based;Population Replacements;prevent;Public Health;Publishing;Resistance;Resistance to infection;Rodent;Role;sugar;Symbiosis;System;Temperature;tissue tropism;tool;trait;transmission blocking;transmission process;urban area;Vaccines;Variant;vector;vector competence;vector mosquito;Wolbachia;Work

PROJECT_TITLE: Exploring Wolbachia for malaria control

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Precision Medicine;Prevention

ORG_CITY: MADISON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing a novel, accurate, interpretable, and user-friendly clinical decision support tool for predicting cardiopulmonary deterioration in hospitalized children. Once accomplished, this research work will result in an actionable tool for early detection and of deteriorating children, thereby facilitating timely intervention and improvement of outcomes. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to enhancing health, lengthening life, and reducing illness and disability.

PI_NAMEs: MAYAMPURATH, ANOOP  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Accident and Emergency department;Achievement;Address;Admission activity;Age;Algorithms;Assessment tool;Awareness;Cardiac Death;Cardiopulmonary;care fragmentation;care providers;Cessation of life;Child;Childhood;Clinical;clinical decision support;clinically relevant;Data;Data Set;Decision Making;deep learning;design;Detection;Deterioration;Diagnosis;Diagnostic;Diagnostic tests;disability;Early Diagnosis;Early identification;Early Intervention;Electronic Health Record;electronic structure;Engineering;Ensure;Event;experience;Functional impairment;Goals;gradient boosting;graphical user interface;Health;Heart Arrest;high risk;Hospitalization;Hospitalized Child;Hospitals;Hour;Human;improved;improved outcome;individual patient;innovation;Intensive Care Units;Intervention;Laboratories;Life;Location;Machine Learning;machine learning algorithm;machine learning method;machine learning model;machine learning prediction;Mechanical ventilation;Methods;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;Natural Language Processing;Neurodevelopmental Impairment;novel;Nurses;Outcome;Output;Patient-Focused Outcomes;Patients;Pediatric Hospitals;pediatric patients;Performance;Pharmaceutical Preparations;Phase;phrases;Physicians;Physiological;Pilot Projects;pre-pandemic;predictive modeling;predictive tools;Public Health;Quality of Care;Research;Risk;Risk Assessment;risk prediction;risk prediction model;satisfaction;Selection for Treatments;support tools;Survivors;System;targeted treatment;tertiary care;Testing;Time;tool;Training;Triage;Trust;trustworthiness;United States National Institutes of Health;usability;user centered design;user-friendly;ward;Work

PROJECT_TITLE: Clinical Decision Support for Early Detection of Deterioration in Hospitalized Children

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]