NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Immunotherapy

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Myocarditis, a serious inflammatory reaction in the heart causing cardiac death, can occur as a result of immune checkpoint inhibitor therapy. Immune checkpoint inhibitors (ICIs) are a novel class of cancer therapeutics which release the brakes on T-cell cytotoxicity against tumor cells but may also lead to T-cell mediated myocarditis. This project aims to define the precise T-cell subsets, identify molecular mechanisms potentiating T-cell activation/expansion, and uncover the culprit antigens in ICI-induced myocarditis, thus paving the way to prevention and cure of this serious side effect of ICIs and helping ensure the cardiovascular safety of cancer patients.

PI_NAMEs: ZHU, HAN  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Acute;Adoptive Transfer;Advanced Malignant Neoplasm;Affect;age group;Antibody Binding Sites;Antigen Targeting;Antigens;Arrhythmia;attenuation;Autoantigens;autocrine;Autoimmune Diseases;Autoimmune myocarditis;Autoimmunity;Biological Assay;Blood;Cancer Patient;candidate identification;Cardiac;Cardiac Death;Cardiovascular system;CCR5 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Separation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;checkpoint therapy;chemokine;Clonal Expansion;Clone Cells;cohort;Computational algorithm;cytokine;Cytometry;cytotoxic;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Disease;Drug Side Effects;Drug Targeting;effective therapy;effector T cell;Ensure;Epitopes;experimental study;Funding;Genetic Transcription;Germ Lines;Goals;Granzyme;Grouping;Heart;heart cell;Heart failure;Histopathology;Homing;Immune;Immune checkpoint inhibitor;Immunological Models;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;insight;Interferon Type II;knock-down;Knockout Mice;Knowledge;Laboratories;Life;Lymphocyte;Lymphocytic Infiltrate;Malignant Neoplasms;Mediating;Molecular;Molecular Profiling;Monoclonal Antibodies;mouse model;Mus;Myocardial;myocardial damage;myocardial injury;Myocarditis;Myocardium;neoplastic cell;new therapeutic target;novel;novel therapeutics;Onset of illness;paracrine;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;perforin;Phenotype;Physicians;Play;Population;Prevention;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Proteins;RANTES;Reaction;receptor;Regulatory Pathway;Reporting;response;Role;Safety;Scientist;side effect;Signal Transduction;single-cell RNA sequencing;skills;Small Interfering RNA;small molecule;Spleen;sudden cardiac death;T cell receptor repertoire sequencing;T cell therapy;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;time use;Tissues;Toxic effect;Translations;tumor;Up-Regulation;Work

PROJECT_TITLE: Identification of Causal T-Cell Mechanisms in Immune Checkpoint Inhibitor Induced Myocarditis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Hypertension;Neurodegenerative;Neurosciences;Nutrition;Physical Activity;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: WINSTON-SALEM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE No pharmacologic treatments have been identified to treat Alzheimer's disease (AD); however, lifestyle interventions targeting modifiable AD risk factors provide a promising evidence-based prevention strategy. The proposed study will add comprehensive assessments of cerebral autoregulation, autonomic function, and vascular structure and function in 500 cognitively normal but at-risk older adults enrolled in a multi-site randomized controlled trial involving an intensive 2-year lifestyle intervention to examine intervention effects on neurovascular mechanisms and their association with cognitive and brain outcomes. The results will provide critical insight into preclinical changes that compromise brain perfusion and may identify an effective strategy for improving neurovascular function, which could have important consequences for preventing AD and related dementias.

PI_NAMEs: BRINKLEY, TINA E (contact);SHALTOUT, HOSSAM

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Activities of Daily Living;Address;Adherence;age related;age related changes;aged;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Ancillary Study;Aorta;arterial spin labeling;Baroreflex;Blood Pressure;Blood Tests;Blood Vessels;Brain;brain health;Brain imaging;Carbon Dioxide;cardiometabolism;cerebral autoregulation;cerebral hemodynamics;cerebral hypoperfusion;cerebral vasomotor reactivity;Cerebrovascular Circulation;clinical research site;Clinical Trials Design;Cognition;Cognitive;cognitive function;cohort;comorbidity;cost effective;dementia risk;design;Development;Diabetes Mellitus;early detection biomarkers;Early Diagnosis;Education;Enrollment;Episodic memory;evidence base;executive function;Exercise;Family history of;Functional disorder;Funding;Goals;Group Meetings;Group Structure;Health;heart rate monitor;hypercholesterolemia;Hypertension;Impaired cognition;Impairment;improved;Infrastructure;Inhalation;innovation;insight;intervention effect;Ischemia;Life Style;lifestyle intervention;Magnetic Resonance Imaging;Measures;Mediterranean Diet;Memory impairment;Metabolic;Monitor;multidisciplinary;Nerve Degeneration;neurovascular;neurovascular coupling;Nutrient;older adult;orthostatic stress;Outcome;Oxygen;Parents;Participant;Perfusion;Pharmacological Treatment;Phenotype;Play;Positron-Emission Tomography;pre-clinical;Predisposition;prevent;Prevention;Prevention strategy;primary outcome;Process;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Regulation;Research Priority;Resources;Rest;Risk;Risk Factors;Risk Reduction;Role;sedentary lifestyle;Site;Structure;targeted treatment;tau Proteins;Techniques;Time;tonometry;treatment arm;ultrasound;Unhealthy Diet

PROJECT_TITLE: The POINTER Neurovascular Ancillary Study


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Heart Disease;Infectious Diseases;Kidney Disease;Lung;Pneumonia;Pneumonia and Influenza;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The coronavirus disease 2019 (COVID-19) pandemic is a public health crisis characterized by pneumonia and multiorgan dysfunction. We propose a novel investigation of the intermediate and long-term cardiac, vascular, and renal consequences of COVID-19. Our approach will investigate the frequency of and risk factors for serious cardiac events in COVID-19 survivors and will characterize changes in vascular and kidney structure and function over time, with a goal of identifying future interventions to mitigate adverse outcomes in these patients.

PI_NAMEs: CHIRINOS MEDINA, JULIO ALONSO (contact);COHEN, JORDANA B.

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Acceleration;Acute;acute coronary syndrome;adjudication;Admission activity;adverse outcome;Albuminuria;Arrhythmia;arterial stiffness;Arteries;Biological Markers;Blood Vessels;brachial artery;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;cerebrovascular;Cessation of life;Characteristics;Chronic;Chronic Kidney Failure;Clinical;Clinical Data;cohort;community acquired pneumonia;comorbidity;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 survivors;Creatinine;density;elastography;Electronic Health Record;Endothelium;Epidemiology;Event;Exhibits;experience;Femur;Fibrosis;Frequencies;Functional disorder;Future;Glomerular Filtration Rate;Goals;Health;Health system;Heart;Heart Diseases;Heart failure;high risk;Hospitalization;Image;in vivo;Incidence;Infection;Inflammatory;Injury;Intervention;Investigation;Kidney;Kidney Diseases;LCN2 gene;long term consequences of COVID-19;Longitudinal cohort study;Measurement;Measures;Mechanical ventilation;Mediating;Microscopy;Natural History;novel;Organ;Outcome;Outcomes Research;Patients;Peripheral arterial disease;Phenotype;Physicians;Physiologic pulse;Pneumonia;post gamma-globulins;post SARS-CoV-2 infection;post-COVID-19;preventive intervention;Process;prospective;Prospective, cohort study;Public Health;rat KIM-1 protein;Records;Recovery;Reference Standards;renal damage;Renal function;Renal Replacement Therapy;Risk;Risk Factors;Risk Reduction;severe COVID-19;sociodemographics;standard measure;Stress;Stroke;Structure;Survivors;symptomatic COVID-19;Techniques;thrombotic;Time;Tissues;Tubular formation;Ultrasonography;Update;urinary;Vascular Diseases;Vascular Endothelium;Vasoconstrictor Agents

PROJECT_TITLE: Cardiovascular Risk, Vascular and Kidney Damage in COVID-19 Survivors

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: DK

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Complementary and Integrative Health

ORG_CITY: BERKELEY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative Activating heat production in a tissue termed brown fat might offer new ways to combat obesity, however, availability of coenzyme Q (CoQ) might limit brown fat activity. Here we will investigate the consequences of CoQ deficiency in brown fat and how the tissue adapts to the scarcity of this important metabolite.

PI_NAMEs: STAHL, ANDREAS  (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Affect;Aging;Anabolism;Animal Testing;Animals;Antioxidants;autocrine;biological adaptation to stress;Brown Fat;Cells;Chronic Disease;cofactor;combat;Communication;Creatine;Data;Defect;Diagnosis;Down-Regulation;Electron Transport;Energy Metabolism;Enzymes;Event;FGF21 gene;fibroblast growth factor 21;Functional disorder;Gene Expression Profile;Genetic Models;Germ-Line Mutation;Human;In Vitro;in vivo;in vivo Model;inhibitor;innovation;knock-down;Knockout Mice;Link;Liver;Location;Mediator;Membrane;Membrane Potentials;Metabolic;Mitochondria;mitochondrial membrane;Mitochondrial Proteins;Modeling;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organ;Oxidation-Reduction;Oxygen;Pathway interactions;pharmacologic;Play;Process;Production;programs;Proteins;Regulation;Respiration;Respiration Disorders;response;Role;Stress;System;Temperature;Testing;Thermogenesis;Tissues;transcriptome sequencing;Ubiquinone

PROJECT_TITLE: Role of CoQ in regulating thermogenesis

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE ! The Charleston Alcohol Research Center is dedicated to addressing one of the nation’s foremost public health concerns: alcohol use disorder. The Center embraces a multidisciplinary, translational research approach involving both clinical and preclinical researchers who are investigating why some individuals transition from social drinking that can be controlled to more excessive, uncontrolled drinking. Understanding brain mechanisms involved in this transition to excessive, compulsive-like alcohol consumption is crucial for developing new and more effective therapeutic strategies for arresting the progression to alcohol addiction, and preventing negative consequences associated with alcohol use disorder.

PI_NAMEs: BECKER, HOWARD C. (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: addiction;Address;Adoption;alcohol abuse therapy;Alcohol consumption;alcohol cue;Alcohol dependence;alcohol effect;alcohol exposure;alcohol research;alcohol seeking behavior;alcohol use disorder;Alcohols;Animals;Area;Basal Ganglia;Basic Science;Behavior Control;Behavioral;Biostatistics Core;Brain;Cellular biology;Chronic;Clinical;clinical investigation;Clinical Investigator;Clinical Research;cognitive capacity;Communication;Corpus striatum structure;craving;Creativeness;Dedications;Development;Discipline;drinking;Education;Educational Activities;Environment;environmental enrichment for laboratory animals;experience;Faculty;flexibility;Fostering;Foundations;frontal lobe;Future;Goals;graduate student;Habits;Heavy Drinking;improved;Individual;Infrastructure;Intake;Leadership;Maps;Mediating;Mission;Modality;Molecular and Cellular Biology;Molecular Biology Techniques;Motivation;multidisciplinary;Nature;neural circuit;neuroadaptation;neuroimaging;next generation;Pattern;pharmacologic;Pilot Projects;Play;Postdoctoral Fellow;pre-clinical;pre-clinical research;prevent;Procedures;Process;Productivity;programs;Psychiatry;Public Health;Research;Research Activity;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;Services;social;Structure;success;Talents;Techniques;Technology;Thalamic structure;Therapeutic;therapeutically effective;Topical application;Training;Training Activity;training opportunity;Translational Research;treatment center;treatment research;undergraduate student;Work

PROJECT_TITLE: Alcohol Research Center - Treatment and Implications


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetic Testing;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: UROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE We propose a resource-driven, patient-centered study to determine the genetic/genomic drivers of homologous recombination deficiency and their role as treatment selection markers for lethal prostate cancer. The focus on liquid biopsies in a vulnerable patient population facing difficult treatment decisions will directly lead to treatment selection strategies to improve clinical management as well as patient selection strategies for clinical trials.

PI_NAMEs: LUO, JUN  (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: abiraterone;Address;Alleles;androgen independent prostate cancer;Androgen Receptor;anti-cancer research;Biological Assay;Blood;Blood specimen;BRCA1 gene;BRCA2 gene;Cancer Patient;Categories;Cells;chemotherapy;Clinical;Clinical Management;Clinical Trials;cohort;Data;Development;Diagnosis;Disease;DNA sequencing;docetaxel;Drug Targeting;enzalutamide;Evaluation;Event;FDA approved;Gene Expression;Genes;Genetic;genetic predictors;genetic testing;genomic biomarker;Genomics;Germ Lines;Goals;homologous recombination deficiency;hormone therapy;improved;Inherited;inhibitor therapy;Knowledge;Lesion;Life;Link;liquid biopsy;Local Therapy;Longitudinal cohort;Malignant neoplasm of prostate;men;Molecular;molecular phenotype;Mutation;mutational status;novel;Operative Surgical Procedures;patient oriented;patient population;Patient Selection;Patients;Pharmaceutical Preparations;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Prediction of Response to Therapy;predictive marker;prospective;Rationalization;Recurrence;Resistance;Resources;response;response biomarker;Role;Sampling;Selection for Treatments;Specimen;standard of care;Systemic Therapy;targeted treatment;taxane;Time;Tissues;transcriptome sequencing;treatment comparison;Treatment outcome;treatment response;tumor;tumor DNA;Work

PROJECT_TITLE: Genetic and genomic determinants of homologous recombination repair deficiency as treatment selection markers for lethal prostate cancer

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

PROJECT_TERMS: Advisory Committees;Alcohol consumption;alcohol research;alcohol use disorder;Alcohols;Awareness;Basic Science;Clinical Research;cohesion;Collaborations;Communication;Communities;Development;Education and Outreach;Educational Activities;Ensure;Environment;environmental enrichment for laboratory animals;Feedback;Fostering;Goals;Individual;Infrastructure;Interdisciplinary Study;Leadership;Link;meetings;Monitor;multidisciplinary;next generation;Online Systems;organizational structure;Philosophy;Pilot Projects;Play;Preparation;Productivity;programs;Quality Control;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resource Allocation;Resource Sharing;Resources;Role;Schedule;Services;Topical application;Training;training opportunity;Translational Research;treatment center;treatment research;Vertebral column;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Immunization;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: CD33 is a validated target for acute myeloid leukemia (AML) immunotherapy but existing therapeutics are ineffective in many patients. Since AML cells are highly radiosensitive across the entire genetic disease spectrum, we plan to develop and optimize a new form of CD33-directed radioimmunotherapy with the a-emitter astatine-211 for use in transplant and non-transplant settings. We believe astatine-211 is ideally suited for targeting CD33 because it deposits high energy over a short distance to enable AML cell kill with limited off- target toxicity and decays without any long-lived or potentially dangerous daughter isotopes.

PI_NAMEs: WALTER, ROLAND BRUNO (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Actinium;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Animal Experiments;Antibodies;Antibody Therapy;Antibody-drug conjugates;Antigen Targeting;Antigens;arm;Astatine;Biodistribution;cell killing;Cell surface;Cells;Characteristics;Clinic;Clinical;clinical development;conditioning;cost;Dangerousness;Daughter;Deposition;Diameter;Distal;early phase clinical trial;ethnic minority population;Gemtuzumab Ozogamicin;Genetic Diseases;Glycoproteins;Goals;Half-Life;Hematopoietic;Human;Human Anti-Mouse Antibody;humanized mouse;Immune system;Immunization;Immunocompetent;Immunotherapy;improved;improved outcome;in vivo;in vivo Model;interest;Isotopes;Label;lead candidate;leukemia;Leukemic Cell;leukemic stem cell;Life Extension;Malignant - descriptor;Membrane;Modeling;mouse model;multidisciplinary;Mus;Neoplasms;Normal Cell;novel;novel strategies;Nude Mice;Organ;particle;Patients;preclinical study;Production;Property;PTPRC gene;Radiation;Radiation Tolerance;Radioimmunoconjugate;Radioimmunotherapy;Radioisotopes;Research Personnel;Risk;Safety;SET Domain;Testing;Therapeutic;therapeutic candidate;Therapeutic Studies;therapeutically effective;Tissues;Toxic effect;Transplantation;Treatment Efficacy;Treatment outcome;Treatment-related toxicity;tumor;Variant;Xenograft Model

PROJECT_TITLE: Novel Approaches to CD33-Directed Radioimmunotherapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative The proposal describes an inter-disciplinary project whose goal is to systematically determine the role of RNA- binding proteins (a set of cellular regulatory proteins that recognize, bind, and regulate mRNAs) in the process of cancer progression. Our preliminary data suggests that these regulators play a disproportionately important role in cancer and our project is a multi-faceted computational/experimental strategy to characterize this landscape. If successful, the project will expand our understanding of cancer pathways in novel directions that may have significant impact on diagnosis and treatment of a variety of cancers.

PI_NAMEs: TAVAZOIE, SAEED F (contact);TAVAZOIE, SOHAIL F.

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Algorithms;Area;Binding;Binding Proteins;Binding Sites;Biochemical;Biological;Biology;breast cancer metastasis;cancer cell;cancer type;Cell Proliferation;Cells;Clinical;Clinical Oncology;clinical prognostic;Clinical stratification;clinically relevant;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Computer Analysis;computer framework;computer studies;CRISPR screen;Data;Diagnosis;Diagnostic;Elements;Exhibits;experimental study;Gene Proteins;Genes;Genetic;Genetic Epistasis;genetic regulatory protein;Genetic Screening;Goals;Human Genome;In Vitro;in vivo;Individual;knock-down;Knowledge;Laboratories;large datasets;loss of function;Malignant Neoplasms;Maps;Mediating;Messenger RNA;MicroRNAs;Molecular;mRNA Expression;mRNA Stability;Mus;Neoplasm Metastasis;novel;Orphan;Pathway interactions;patient stratification;Patients;Phenotype;Play;Positioning Attribute;posttranscriptional;Precision therapeutics;Primary Neoplasm;Process;prognostic;Recording of previous events;Regulatory Element;Regulatory Pathway;Regulon;Research;RNA;RNA Sequences;RNA-Binding Proteins;Role;Sampling;small hairpin RNA;Stratification;Technology;The Cancer Genome Atlas;Therapeutic Intervention;Tissue-Specific Gene Expression;Transcript;transcription factor;transcriptome;tumor;tumor growth;tumor progression;tumorigenesis;Universities;Untranslated RNA;Work;Xenograft Model

PROJECT_TITLE: Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Nutrition;Obesity;Precision Medicine

PHR: Type 2 diabetes affects 30.3 million people in the U.S., and the reasons why some people with diabetes suffer worse diabetes complications are not well understood. For many people with diabetes, differences in the immune system may play an important role in how diabetes progresses. This research project will measure immune system differences in blood samples from people with diabetes to understand how these differences affect their diabetes complications and outcomes so that we can develop better, more individualized treatment approaches.

PI_NAMEs: MARUTHUR, NISA M (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Address;adult obesity;Affect;Antibodies;Antigens;Autoantibodies;Autoimmune;Autoimmunity;Bayesian Modeling;Beta Cell;Biological Assay;Blood specimen;Caring;Cell Physiology;Classification;Clinical;clinical effect;clinical phenotype;clinically significant;Cluster Analysis;cohort;Complications of Diabetes Mellitus;Data;data visualization;Diabetes Mellitus;Diagnosis;Disease;disease model;Epidemiology;Epitopes;Failure;follow-up;Future;glycemic control;Goals;Health;Heterogeneity;high risk;Immune system;Immunoglobulin G;Immunologics;improved;individualized medicine;Insulin Resistance;insulinoma;interactive visualization;islet autoimmunity;islet cell antibody;Knowledge;Laboratories;lifestyle intervention;Longitudinal cohort;Malignant neoplasm of prostate;Measures;Modeling;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Onset of illness;Outcome;Overweight;Participant;Patients;Pattern;Persons;Phenotype;Pilot Projects;Play;precision medicine;preservation;Prevalence;Prognosis;randomized trial;Research Project Grants;Risk;Role;Scleroderma;Self Direction;Specificity;Structure of beta Cell of islet;Subgroup;Techniques;Testing;Time;tool;treatment response;trend;Visualization;Visualization software;Work;zinc-binding protein

PROJECT_TITLE: Utilizing islet autoantibody signatures for precision medicine in type 2 diabetes

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

PI_NAMEs: WOODWARD, JOHN J. (contact)

PROJECT_TERMS: Acute;Affect;Air;Alcohol abuse;alcohol availability;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol research;alcohol sensitivity;alcohol use disorder;Alcohols;Amygdaloid structure;Animals;Area;Astrocytes;Basic Science;Behavior;Behavior Control;Behavioral;behavioral outcome;Brain;brain circuitry;Calcium;Chronic;Clinical;Color;Complement;Consumption;Corpus striatum structure;Coupled;Data;Decision Making;density;designer receptors exclusively activated by designer drugs;Dopamine D1 Receptor;Dorsal;drinking;Electrophysiology (science);Emotional;Empirical Research;Ethanol;Excitotoxic lesion;experience;Female;Fiber;flexibility;Follow-Up Studies;Funding;Glutamates;Glycine;Glycine Receptors;Goals;Heavy Drinking;imaging approach;Impairment;In Vitro;in vivo;Individual;Intoxication;Label;Learning;Link;maladaptive behavior;male;Measures;Medial;Mediating;Monitor;monoamine;mouse model;Mus;neural;neural circuit;Neuromodulator;Neurons;neurotransmission;optogenetics;Output;Pathway interactions;Performance;Photometry;Play;Potassium;Prefrontal Cortex;Quinine;receptor;Recreation;Regulation;Reporter Genes;Research Project Grants;Resistance;Reversal Learning;Rewards;Risk Assessment;Role;Self Administration;Self Stimulation;sensory integration;Serotonin;Slice;social;Stream;Structure;Sucrose;Synapses;Testing;Thalamic structure;Time;Transgenic Organisms;treatment center;Vertebral column

PROJECT_TITLE: Effect of Chronic Alcohol Exposure on OFC-BLA-Striatal Circuitry and Excessive Alcohol Drinking


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: EAST LANSING

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Contemporary theories of schizophrenia posit that symptoms arise from deficits in using prior experience to form predictions about sensory information and in using these predictions to help interpret the world; however, an empirical basis for delineating the specific nature of these deficits is lacking. The visual system is uniquely suited for the experimental study of prediction abnormalities in schizophrenia. The current project focuses on visual adaptation – a canonical form of experience-dependence in visual processing – to characterize alterations in the influence of prior experience in schizophrenia, at the level of brain and behavior, and to identify the clinical significance of these alterations.

PI_NAMEs: THAKKAR, KATHARINE NATASHA (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Animals;Bayesian Analysis;Bayesian Modeling;Behavior;Behavioral Paradigm;Belief;Biological;Brain;Chronic;Chronic Schizophrenia;Clinical;clinically relevant;clinically significant;Cognitive;Complex;Computer Models;Conscious;Data;Delusions;Dependence;Detection;Disabling;disorder risk;Distress;effective therapy;Environment;experience;experimental study;Face;Functional disorder;Functional Magnetic Resonance Imaging;functional outcomes;Goals;Hallucinations;Human;Image;indexing;Individual;insight;Link;Literature;Measures;Methodology;Modeling;Motivation;Nature;neural;neuroadaptation;neuroimaging;neuromechanism;Neurons;neurophysiology;Neurophysiology - biologic function;neurotransmission;Onset of illness;Patients;Pattern;Perception;Perceptual disturbance;Pharmacology;phenomenological models;Population;Process;Property;Psyche structure;Psychotic Disorders;psychotic-like experiences;Reporting;response;Schizophrenia;schizophrenia spectrum disorder;Sensory;sensory input;Severities;Statistical Models;Structure;Symptoms;Synapses;System;Testing;theories;tool;Update;Vision;Visual;visual adaptation;Visual Cortex;Visual Perception;visual processing;visual stimulus;Visual System;Volatilization;Work

PROJECT_TITLE: Visual perception as a window onto prediction anomalies in schizophrenia

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE In utero exposure to ethanol at low doses, known to contribute to fetal alcohol spectrum disorders and increase risk for alcohol use disorders, is shown in rodents to stimulate in the hypothalamus both hypocretin/orexin peptide neurons that play a major role in alcohol intake and abuse and local inflammatory neuroimmune systems. In a transparent zebrafish model, we will use live imaging to characterize, at a single-cell level and in real-time across developmental stages, these effects of embryonic ethanol exposure on this neuropeptide system, test if the observed changes are causally related to disturbances in behavior, and determine if specific inflammatory chemokine systems have a functional role in mediating these lasting neuronal and behavioral disturbances. This research will increase our fundamental understanding of the long-term effects of embryonic ethanol exposure at low levels, creating a stronger foundation for developing improved strategies for prevention or reversal of the serious consequences from maternal consumption of even small amounts of ethanol during pregnancy.

PI_NAMEs: LEIBOWITZ, SARAH F. (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Ablation;Adult;Affect;Age;Agonist;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol exposure;alcohol risk;alcohol use disorder;Anatomy;antagonist;Anxiety;Appetite Stimulants;Area;Behavior;behavior test;Behavioral;behavioral pharmacology;Biological Models;Brain;Calcium;CCL2 gene;Cells;chemokine;Chronic;Clinical;Communication;Consumption;cost;cytotoxic;Date of birth;density;Development;Dose;Embryo;embryonic alcohol exposure;Embryonic Development;Embryonic Induction;Ethanol;Exhibits;experimental study;Exposure to;fetal;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Foundations;Genetic;Human;hypocretin;Hypothalamic structure;Image;improved;in utero;in vivo calcium imaging;Individual;Inflammatory;Injections;Knock-out;Laboratories;Lasers;Left;Life;Lifestyle-related condition;Location;Long-Term Effects;Measures;Mediating;Mental disorders;Methodology;migration;Modeling;Molecular;monocyte chemoattractant protein 1 receptor;mutant;neural;neurodevelopment;neurogenesis;Neuroimmune;Neuroimmune system;neuron development;Neurons;Neuropeptides;novel;offspring;Optics;optogenetics;Pattern;Peptides;Physiological;Play;pre-clinical;Pregnancy;prenatal;prenatal exposure;Prevention strategy;Property;Publications;Rattus;receptor;Research;Resolution;Risk;Rodent;Rodent Model;Role;Side;Signal Transduction;Site;System;Techniques;Testing;Time;Transgenic Organisms;Zebrafish

PROJECT_TITLE: Mechanisms underlying diverse effects of low-dose embryonic ethanol on development and function of hypocretin/orexin neurons

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The proposed research aims to determine how mechanical forces exerted from extracellular matrix in the tumor microenvironment are translated into biochemical signals to promote tumor invasion and metastasis. We believe that this work could uncover a novel regulatory machinery of tumor invasion and provide new targets for anti-metastasis therapy.

PI_NAMEs: YANG, JING  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: 3-Dimensional;arm;Automobile Driving;Biochemical;Breast Cancer Patient;breast cancer progression;cancer cell;Cell Nucleus;clinically significant;Collagen Fiber;Cytoplasm;Data;Distant Metastasis;Ensure;EPHA2 gene;Epithelium;Extracellular Matrix;Family;G3BP1 gene;Genetic Transcription;Goals;Hardness;Human;in vivo;Invaded;Link;LYN gene;Malignant Breast Neoplasm;malignant phenotype;mammary;mammary epithelium;Mammary gland;Mammary Neoplasms;Manuals;mechanical force;mechanical properties;mechanotransduction;Mesenchymal;Molecular;Mus;Neoplasm Metastasis;Nodule;Normal tissue morphology;novel;Nuclear;Nuclear Translocation;Organoids;Outcome;Palpation;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Play;prevent;Protein Dephosphorylation;Proteins;reconstitution;recruit;Regulation;Research;response;Role;Signal Pathway;Signal Transduction;Site;Testing;therapeutic target;Tissues;transcription factor;Translating;tumor;Tumor Cell Invasion;tumor microenvironment;Tumor Promotion;TWIST1 gene;TYK2;Work

PROJECT_TITLE: Regulation of Tumor Invasion and Metastasis by Matrix Stiffness

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Neurosciences

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  In a sample of 200 young and middle age adult romantic couples assessed over 7 months, the Connected Lives: Overcoming the Self through Empathy (CLOSE) Study will investigate whether the harmful effects of repetitive negative thinking (RNT) on social and mental health also extend to one’s romantic partner. By combining data from a novel neuroimaging empathy task with data from two smartphone apps designed measure thought and behavior in everyday life, the CLOSE study tests the hypothesis that RNT impairs participants’ ability to empathize (and thus socially connect) with their partners, which exacerbates negative health consequences for both members of the relationship. This work holds promise for advancing our understanding of how individual and social risks for psychopathology operate together to shape emotional disorders with the ultimate goal of identifying novel intervention targets to strengthen social connectedness in the service of improving mental health.

PI_NAMEs: ANDREWS-HANNA, JESSICA RENEE (contact);SBARRA, DAVID A

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Anxiety;Area;Behavior;Behavioral;biopsychosocial factor;Brain;brain behavior;Couples;Data;design;Diagnostic;Disparate;Emotional;Emotional disorder;Emotions;Empathy;Feedback;Feeling;Functional Magnetic Resonance Imaging;Future;Goals;Health;Heart;Hostility;Impaired health;Impairment;improved;Individual;interest;Intervention;Life;Link;Loneliness;Measures;Mediating;member;Mental Depression;Mental disorders;Mental Health;Methods;middle age;Mind;mobile application;Modeling;negative affect;neural;neuroimaging;novel;Outcome;Participant;Partner in relationship;Patient Self-Report;Pattern;Personal Satisfaction;primary outcome;prospective;Psyche structure;Psychopathology;Questionnaires;Research;Research Design;Research Personnel;Risk;Risk Factors;Role;Sampling;Scientific Advances and Accomplishments;Services;Shapes;smartphone application;social;Social Behavior;social factors;social integration;social relationships;statistics;Stress;Symptoms;Testing;Thinking;Time;trait;Work;young adult

PROJECT_TITLE: Connected Lives - Overcoming the Self through Empathy (CLOSE): A Dyadic, Multi-Method Study


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Narrative Whether bacterial or human, cells transform their proteomic content to adapt and proliferate. The most efficient proteome design in turn dominates the evolutionary dynamics within microbial communities or cancer populations. By investigating the design principles for how to construct an effective proteome, we will provide insights for attacking proteome homeostasis in bacterial pathogens and disease cells.

PI_NAMEs: LI, GENE-WEI  (contact)

PROGRAM_OFFICER_NAME: SINHA, SANGITA C

PROJECT_TERMS: Area;Bacillus subtilis;Bacterial Genes;Bacterial Infections;Bacterial Model;Bacteriophages;Biological Assay;Biological Models;Cell Physiology;cell transformation;Cells;Coupled;design;Disease;Dissection;driving force;environmental change;Evolution;fitness;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Genomics;Goals;Grant;Growth;holistic approach;Homeostasis;Human;insight;Knowledge;Logic;Malignant Neoplasms;Measures;Messenger RNA;Methods;microbial community;model organism;Modeling;Molecular;Output;pathogenic bacteria;Physiological;Physiology;Polymerase;Population;predictive modeling;Process;Production;programs;Proliferating;protein function;Proteins;Proteome;Proteomics;Regulation;Research;response;rho;Ribosomes;Runaway;Shapes;stoichiometry;System;Technology;Thinking;transcription termination

PROJECT_TITLE: Evolution and Regulation of Bacterial Proteome Composition

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Burden of Illness;Clinical Research;Neurosciences;Substance Misuse

PI_NAMEs: PRISCIANDARO, JAMES JOSEPH (contact)

PROJECT_TERMS: acamprosate;Acute;Advanced Development;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol cue;alcohol research;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Anatomy;Animals;Anterior;Anti-Anxiety Agents;Brain;Brain region;burden of illness;cingulate cortex;Clinical Research;cognitive control;Consumption;Corpus striatum structure;cost;cue reactivity;Development;Diagnosis;disability-adjusted life years;Disulfiram;drinking;DSM-V;Environment;European Union;FDA approved;Functional Magnetic Resonance Imaging;functional MRI scan;gamma-Aminobutyric Acid;Glutamates;Health Care Costs;Health Expenditures;healthy volunteer;improved;Individual;interest;Investigation;Italy;Laboratories;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Medial;Mediating;Mediator;mortality;MRI Scans;Naltrexone;neurochemistry;neuroimaging;neurotransmission;novel;Participant;Pathologic;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacological Treatment;Phase;Placebos;pre-clinical;pre-clinical research;Prefrontal Cortex;Private Sector;Procedures;Productivity;Property;Protons;Public Health;public health research;Randomized;receptor;Research;research and development;Research Personnel;Research Project Grants;Safety;Self Administration;Societies;Symptoms;Therapeutic;therapeutic target;treatment center;treatment duration;United States;Ventral Striatum;Violence

PROJECT_TITLE: Effects of a Novel mGluR5 Negative Allosteric Modulator on Alcohol Drinking, Neurochemistry, and Brain Reactivity to Alcohol Cues in Alcohol Use Disorder


NIH_SPENDING_CATS: Atherosclerosis;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Prevention

ORG_DEPT: PHYSIOLOGY

PHR: The goal of this proposal is to define the molecular mechanisms that underlie insulin's control of hepatic lipid metabolism with the goal of identifying new therapeutic targets for metabolic diseases associated with abnormal lipid metabolism. In particular, this project will focus on the regulation of phospholipid biosynthesis and the initiation and progression of NAFLD by hepatic mTORC1 signaling.

PI_NAMEs: TITCHENELL, PAUL MICHAEL (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acceleration;Acute;Affect;Anabolism;Arterial Fatty Streak;Atherogenic Diet;Atherosclerosis;Automobile Driving;Biogenesis;Biological;Cardiometabolic Disease;Cell Death;cell growth;Cell Physiology;Cell Proliferation;Cholesterol;choline deficient diet;Communities;Cytidine Diphosphate Choline;detection of nutrient;Development;Diet;Disease;Dyslipidemias;effectiveness testing;Enzymes;experimental study;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;feeding;Foundations;Fructose;Functional disorder;Genetic;Genetic Epistasis;Goals;Health;Hepatic;Hepatocyte;hepatoprotective;Homeostasis;Human;improved;In Vitro;in vivo;insight;Insulin;Insulin Resistance;insulin signaling;Intervention Studies;Kinetics;Knockout Mice;Knowledge;Laboratories;Lecithin;Leucine;lipid disorder;lipid metabolism;Lipids;Lipoproteins;Liver;Liver diseases;Liver Dysfunction;Liver Fibrosis;liver function;loss of function mutation;Low-Density Lipoproteins;Mammalian Cell;Measures;Mediating;Metabolic Diseases;Metabolic Pathway;Metabolism;Modeling;Modification;Molecular;mouse model;Mus;Mutagenesis;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Nutrient;Nutritional;Pathogenesis;Pathway interactions;Phenotype;Phosphatidylcholine Biosynthesis;Phospholipid Metabolism;Phospholipids;Phosphorylation;Phosphorylation Site;Population;prevent;Process;Production;Proteins;Proto-Oncogene Proteins c-akt;Regulation;Research;Risk;Risk Factors;Role;Signal Induction;Signal Transduction;Structure;Testing;Therapeutic;Therapeutic Effect;therapeutically effective;Translating;Triglycerides;TSC1 gene;Tumor Suppressor Proteins;uptake;Very low density lipoprotein;Work

PROJECT_TITLE: Hepatic mTORC1 Signaling and the Regulation of Lipid Homeostasis

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


NIH_SPENDING_CATS: Cancer;Skin Cancer

PHR: PROJECT NARRATIVE This research will evaluate how a novel class of peptide-based inhibitors of the cancer protein focal adhesion kinase (FAK) blocks melanoma cell invasion and survival through disruption of the focal adhesion complex. It will utilize CRISPR-engineered melanoma cell models test the sensitivity of a specific subtype of melanoma (NRAS-mutant) to peptide inhibitors of FAK. Furthermore, it will utilize patient derived xenograft (PDX) mouse models of melanoma to validate FAK inhibitor efficacy in vivo.

PI_NAMEs: MARLOWE, TIMOTHY A (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: 3-Dimensional;Adhesions;Aftercare;angiogenesis;anti-cancer;Antineoplastic Agents;Apoptosis;Binding;Biological;Biological Assay;BRAF gene;cancer cell;cancer subtypes;Cell Line;Cell model;cell motility;Cell Survival;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Crystallization;Crystallography;Data;Dependence;Development;Drug Kinetics;Drug Targeting;Engineering;Enzymes;Evaluation;Extracellular Matrix;Focal Adhesion Kinase 1;Focal Adhesions;Funding;gene-editing approach;Genetic;Immune Cell Suppression;improved;In Vitro;in vivo;inhibitor;inhibitor therapy;Invaded;kinase inhibitor;Lead;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Melanoma;Melanoma Cell;migration;Molecular;Monitor;mouse model;mutant;Mutation;myristoylation;nanomolar;Neoplasm Metastasis;Normal tissue morphology;novel;Oncology;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;paxillin;Peptides;Permeability;Pharmaceutical Preparations;Phase I Clinical Trials;Phase II Clinical Trials;Phosphotransferases;Progress Reports;Proliferating;Property;protein complex;Protein Tyrosine Kinase;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Ras/Raf;Regulation;Research;Resistance;response;Roentgen Rays;Role;scaffold;Scaffolding Protein;Series;Signal Pathway;Signal Transduction;Skin Cancer;Solid Neoplasm;stapled peptide;Talin;targeted treatment;Techniques;Tertiary Protein Structure;Testing;Therapeutic;tumor;Tumor Biology;tumor progression;tumor xenograft

PROJECT_TITLE: Focal Adhesion Kinase - Tumor Biology and Therapeutics

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


PI_NAMEs: CHANDLER, L JUDSON (contact)

PROJECT_TERMS: Acute;addiction;Alcohol dependence;alcohol exposure;alcohol research;alcohol seeking behavior;alcohol use disorder;Alcohols;Animal Model;Animals;Behavior;Behavior Control;Behavioral;biophysical properties;Brain;Brain region;Calcium;cell type;Cells;Chronic;Clinical Research;comparison control;Consumption;Corpus striatum structure;Data;Dependence;Development;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;drinking;drinking behavior;drug seeking behavior;effective therapy;Electrodes;Electrophysiology (science);Elements;Ethanol;experimental study;Fiber;flexibility;Genetic;Goals;Habits;Human;human imaging;imaging study;Impairment;in vivo;Individual;Knowledge;Laboratories;male;Medial;Mediating;mouse model;Mus;neural circuit;neural network;Neurobiology;Neurons;neurotransmission;new therapeutic target;Outcome;patch clamp;Pharmaceutical Preparations;Photometry;Play;Population;pre-clinical research;Prefrontal Cortex;problem drinker;Process;Publishing;Reporting;Research;Research Project Grants;response;Rewards;Role;Site;Slice;Sucrose;Testing;treatment center;Visual

PROJECT_TITLE: Adaptations in Corticostriatal Networks in Alcohol Dependence Related Goal-Directed and Habitual Drinking


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Although many mutations in retinitis pigmentosa (RP) arise in rod-specific genes, it is secondary loss of cone function, leading to diminished high-resolution daylight vision that is most debilitating. We provide evidence glucose transport from RPE to photoreceptors is diminished in RP, causing their starvation and loss of function. A pathway regulating glucose transport is identified, and we link its deregulation to RPE metabolome changes in RP.

PI_NAMEs: DEAN, DOUGLAS CHASE (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Adaptor Signaling Protein;Age;AKT inhibition;alpha ketoglutarate;Animal Model;Apical;Arrestins;Automobile Driving;Back;Binding;Birth;Blood;blood glucose regulation;Catheters;Cell Death;Cells;Choroid;Circulation;Clathrin;coated pit;cofactor;Complex;Cone;Cytoplasm;Cytoskeletal Modeling;Dark Adaptation;Development;Disease;Disease Progression;DNA;Down-Regulation;Endocytosis;enhancing factor;Environment;Epigenetic Process;epigenome;Epithelial Cells;Event;experimental study;Face;Family;Family suidae;Feedback;Feeds;functional loss;Gene Expression;Genes;Glucose;glucose metabolism;glucose transport;Glucose Transport Induction;Glucose Transporter;glucose uptake;GLUT 4 protein;GLUT-1 protein;histone demethylase;Hypoglycemia;inhibitor;Injections;Insulin;Integrins;Investigation;Label;Light;Link;Lipids;loss of function;Macrophage;Malignant Neoplasms;Mass Spectrum Analysis;Metabolic;Metabolic Pathway;Metabolism;metabolome;Modeling;Mus;mutant;Mutation;Neurons;Nutrient;overexpression;Pathway interactions;Peripheral;Phagocytosis;Phagocytosis Induction;Phosphatidylserines;Phosphorylation;Photoreceptors;prevent;Proteins;Reading;receptor;recruit;Regulation;Resolution;response;restoration;Retina;Retinal Pigments;retinal rods;Retinitis Pigmentosa;Rod;Rod Outer Segments;scaffold;Signal Pathway;Signal Transduction;Starvation;Structure of retinal pigment epithelium;subretinal injection;Surface;Transplantation;uptake;Vision;Visual;Work

PROJECT_TITLE: Blood outer retina barrier regulation

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE The University of Alabama at Birmingham (UAB) Superfund Research Program (UAB- SRP) will address airborne pollution with heavy metals in down town Birmingham, Alabama. The UAB-SRP will work with the community and Superfund stakeholders to better define the issues related to the lung health of the residents of the North Birmingham 35th Avenue site and the health of the environment. These innovative projects will address lung disease in residents and define ways to mitigate environmental degradation and improve human health.!

PI_NAMEs: ANTONY, VEENA B. (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: 3-Dimensional;aerosolized;Affect;African American;Air;Air Pollution;Alabama;Amendment;Area;Arsenic;Arts;Asthma;Authorization documentation;biobank;Biological;Biological Markers;biomarker validation;Blood;Bronchoalveolar Lavage Fluid;Cadmium;Childhood Asthma;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;cigarette smoke;Civil Rights;coal-fired power plant;Coke;college;Communication;Communities;community academic partnership;community engagement;cost effective;County;Data;demographics;Detection;Developed Countries;Development;Disease;disease phenotype;disease registry;empowerment;Engineering;Environment;Environmental Engineering technology;Environmental Exposure;Environmental Health;Environmental Medicine;Environmental Science;Epidemiology;Equity;Excision;Exhalation;Exposure to;Fostering;Goals;Health;Heart;Heavy Metals;Home;Human;human subject;Hybrids;improved;Incidence;Industrialization;Industry;Inhalation;innovation;Knowledge;Lead;Link;Low income;Lower Respiratory Tract Infection;Lung;Lung Diseases;lung health;lung injury;Manganese;Measures;medical schools;Metal exposure;Methodology;Methods;Mission;Modality;Molecular;mortality;multidisciplinary;nano;National Institute of Environmental Health Sciences;next generation;Non-Invasive Detection;Nose;novel;Optics;Organoids;Pathogenesis;Patients;Persons;Phenotype;Physical condensation;Poison;Pollution;Population;Post-Translational Protein Processing;Predisposition;Prevalence;Process;programs;Public Health Schools;remediation;Research;Resources;respiratory health;Respiratory System;response;Risk;Risk Factors;Role;Schools;Science;Scientist;Services;Signal Recognition Particle;Site;Smoking;Socioeconomic Status;Soil;Specimen;Steel;Study Subject;Superfund;superfund site;Surface;synergism;System;Technology;Tennessee;tool;Toxic Environmental Substances;toxicant;Toxicology;Training Programs;Translational Research;United States;United States Environmental Protection Agency;Universities;Work

PROJECT_TITLE: Impact of Airborne Heavy Metals on Lung Disease and the Environment


NIH_SPENDING_CATS: Biotechnology;Cooley's Anemia;Hematology;Orphan Drug;Osteoporosis;Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Despite significant improvements in management and reversal of multiple complications of the disease, even optimally treated patients with β -thalassemia continue to suffer from bone loss and increased risk of bone fractures. We recently demonstrated that protein, synthesis ERFE providing thalassemia a bone marrow secreted erythroferrone (ERFE), that is involved in coordinating iron availability for hemoglobin  is also produced by bone cells. Our preliminary data supports the hypothesis that is involved in coordinating iron metabolism, hemoglobin synthesis, and bone health, rationale in the current proposal to evaluate in detail how excess ERFE in β contributes to or protects from bone dysfunction.

PI_NAMEs: GINZBURG, YELENA  (contact);YUEN, TONY ;ZAIDI, MONE

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: American Society of Hematology;beta Thalassemia;BMP15 gene;BMP2 gene;bone;bone cell;Bone Density;Bone Diseases;Bone Formation Stimulation;bone health;bone loss;Bone Marrow;bone mass;bone metabolism;Bone Morphogenetic Proteins;Bone remodeling;Bone Resorption;Cell Culture Techniques;Cells;Chronic;Complex;Cooley's anemia;cortical bone;Data;Dependence;Disease;Endocrine;Erythroblasts;Erythroid;Erythropoiesis;Evaluation;Exhibits;Femur;Fracture;Functional disorder;Genes;Goals;Hemoglobin;hepcidin;Homeostasis;Human;improved;in vitro Assay;inhibitor;insight;Iron;iron absorption;iron metabolism;Iron Overload;Knock-out;Lead;Literature;Messenger RNA;Metabolic;Metabolic Bone Diseases;mimetics;mineralization;Modeling;mouse model;Mus;novel;novel therapeutics;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteopenia;Osteoporosis;osteoprotective;Pathway interactions;Patients;Pelvis;Phenotype;Play;Process;programs;protein function;Protein Secretion;Proteins;Publications;Recombinants;Recycling;Regulation;response;Risk;Role;Signal Pathway;Signaling Protein;skeletal;Stress;stress state;Thalassemia;thalassemia intermedia;Therapeutic;Thinness;Tissues;Transfusion;translational potential;treatment optimization

PROJECT_TITLE: The Role of Erythroferrone in Regulating Bone Metabolism in Beta-Thalassemia

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Social Determinants of Health

PHR: The Administrative, and Research Translation core manage all administrative arenas of the University of Alabama at Birmingham’s Superfund Research Program (UAB-SRP). It will act as the coordinating center for all five Projects and five Cores. It will provide, Research Translation all communication with its stake holders, Region 4 EPA and ATSDR, the community and the program staff at in the Superfund Program at the NIEHS. It will support an innovative Visiting Professor Program, and be the central hub for innovation, and communication for the UAB-SRP

PROJECT_TERMS: Advisory Committees;Alabama;Articulation;biobank;Bioinformatics;Budgets;Clinical;clinical center;Clinical Sciences;Collaborations;Communication;Communities;community engagement;computerized data processing;computing resources;design;Development;Discipline;early detection biomarkers;Ensure;Environment;Environmental Exposure;Environmental Pollution;Expenditure;experience;Exposure to;Fostering;Future;Generations;Goals;Grant;Health Disparities Research;Heavy Metals;Human Resources;Infrastructure;Inhalation;innovation;interest;Leadership;Lung;Lung Diseases;lung health;Measures;meetings;minority health;minority health disparity;Mission;Monitor;multidisciplinary;National Institute of Environmental Health Sciences;next generation;Occupational activity of managing finances;Office of Administrative Management;Personnel Management;Productivity;professor;programs;Progress Reports;Publications;rapid technique;remediation;Reporting;Research;Research Personnel;Resource Sharing;Resources;Schedule;Science;Scientist;Services;Signal Recognition Particle;Structure;Superfund;synergism;Tennessee;Therapeutic;Training;Translational Research;Translations;treatment strategy;Universities;Vision;Visit

PROJECT_TITLE: Core A Administrative and Research Translation


NIH_SPENDING_CATS: Lung;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE The Data Management and Analysis Core (DMAC) provides centralized biostatistics as well as collaborative research and data management support for the research projects of the University of Alabama at Birmingham (UAB) Superfund Research Program (UAB-SRP). Through collaboration and consultation, the DMAC will provide UAB-SRP investigators with assistance and direction in their experimental design, data collection, data management, and interim and final statistical data analysis. The DMAC will lead the data integration and serve as the focal point from which UAB-SRP investigators and trainees, including basic scientists, biomedical researchers, and clinicians, can draw data management and statistical expertise for the communication and analysis of their research projects.

PI_NAMEs: BAE, SEJONG  (contact)

PROJECT_TERMS: Air;airway remodeling;Alabama;Asthma;Basic Science;biomarker discovery;biomedical scientist;Biometry;Childhood Asthma;Chronic Obstructive Pulmonary Disease;Collaborations;Communication;Communities;complex data;Consultations;Data;Data Analyses;Data Collection;data collection methodology;data integration;data management;data quality;data sharing;Data Storage and Retrieval;Database Management Systems;Databases;design;Doctor of Philosophy;Engineering;Ensure;Environment;Excision;experience;Experimental Designs;Exposure to;FAIR principles;Goals;Heavy Metals;Human;Hybrids;innovation;Lead;Lower Respiratory Tract Infection;Lung Diseases;lung injury;Metal exposure;Methods;Modeling;nano;novel;Outcome Study;Patients;pre-clinical;Predisposition;Procedures;Program Research Project Grants;programs;Publications;quality assurance;Regulation;remediation;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Respiratory Tract Infections;Sampling;Scientist;Secondary to;Site;social;Soil;Statistical Data Interpretation;Superfund;therapeutic target;Training;Translations;United States National Institutes of Health;Universities;user-friendly;Visualization

PROJECT_TITLE: Core B Data Management and Analysis (DMAC)


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SANTA BARBARA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: PROJECT NARRATIVE The genome within all cells of a mammalian system is identical, yet distinct cell types display varied phenotypes due to differences in their epigenome that play a key role in regulating gene expression, and dysregulation of these regulatory factors is associated with developmental disorders, cancer and aging. Current techniques to map epigenetic landscapes in different cell types are dependent on the ability to isolate these cell types at high purity using cell surface markers and high-quality antibodies that are frequently unavailable, or through the expression of cell type-specific fluorescent reporters in transgenic animal models that are extremely time intensive to generate. Therefore, in this proposal we plan to develop single-cell multiomics technologies to simultaneously quantify the transcriptome and different epigenetic marks/features from the same cell, thereby enabling unbiased cell type identification in silico using the transcriptome and quantification of gene regulatory landscapes by pooling together the epigenome of cells that correspond to the same cell type, resulting in an marker-free approach to map the epigenome of different cell types, including rare ones, within complex tissues.

PI_NAMEs: DEY, SIDDHARTH SUBHAS (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Address;Aging;Animal Model;Antibodies;Bar Codes;Binding;Biochemical;Biological Assay;Cell Line;Cell Separation;Cell surface;cell type;Cells;Chromatin;Chromosome Mapping;combinatorial;Complex;Consumption;Data;Development;developmental disease;Disease;DNA;DNA Methylation;DNA-Protein Interaction;Epigenetic Process;epigenome;experimental study;Eye;Fluorescence;Frequencies;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Genome;Genome Mappings;genome-wide;Genomic DNA;Goals;high throughput technology;histone modification;Homeostasis;Human;improved;in silico;in vivo;Investigation;Knowledge;Malignant Neoplasms;Maps;Measurement;Messenger RNA;Methods;methylome;multiple omics;neural;new technology;Nuclear Lamina;Nucleic Acids;Organism;Pattern;Phenotype;physical separation;Play;Polycomb;Process;programs;Proteins;Rattus;Reporter;Retina;Sampling;Science;single cell sequencing;single cell technology;System;Techniques;Technology;Time;Tissue Sample;Tissues;transcription factor;transcriptome;transcriptomics;Transgenic Animals;Work

PROJECT_TITLE: A marker-free technology for mapping the epigenome of cell types in mammalian tissues

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative In this project, we will determine the conditions under which new motor memories are created, how existing motor memories are updated and the rules by which they generalize to new tasks. This project will contribute to funda- mental knowledge on the mechanisms of human motor learning with both empirical work and the development of a novel computational framework for motor learning. This knowledge has the potential to be used to understand deficits in neurological disorders and develop paradigms that can improve rehabilitation.

PI_NAMEs: WOLPERT, DANIEL  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Computations in Human Motor Learning

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Prevention;Social Determinants of Health

PHR: COMMUNITY ENGAGEMENT CORE (CEC) Project Narrative Communities proximate to sources of environmental contamination are adversely affected both by ongoing exposure and resulting health issues. Most often, these communities are also economically disadvantaged and lack the resources and capacity needed to overcome the impact of hazardous substance exposure. As such, the Community Engagement Core (CEC) will facilitate the development and maintenance of an infrastructure to support culturally-appropriate remediation of risks and/or complications of chronic lung diseases and resilience in communities impacted by hazardous substances.

PI_NAMEs: BASKIN, MONICA L. (contact)

PROJECT_TERMS: Address;Adoption;Affect;African American population;Area;Chronic lung disease;Cities;Civil Rights;coal-fired power plant;Coke;Collaborations;Communication;Communities;community academic partnership;community advisory board;community based participatory research;community engaged research;community engagement;Community Health;Community Participation;design;Development;economic disparity;Education;Educational Materials;Effectiveness;effectiveness evaluation;Electronics;Environment;Environmental Exposure;Environmental Hazards;Environmental Health;Environmental Pollution;Event;evidence base;Exposure to;Funding;Goals;hazard;Hazardous Substances;Health;health disparity;Health education;health literacy;Health Promotion and Education;Health protection;Heavy Metals;Housing;improved;Industrialization;Infrastructure;Intervention;Knowledge;Learning;Lung Diseases;Maintenance;member;Metal exposure;Methods;Monitor;Movement;multidisciplinary;Neighborhoods;organizational structure;Perception;Personal Satisfaction;pilot test;Poverty;prevent;Prevention;prevention practice;Prevention strategy;Preventive Medicine;Quality of life;Recommendation;Recording of previous events;remediation;Research;Research Activity;Research Personnel;Research Project Grants;resilience;Resources;respiratory health;Risk;Risk Reduction;Role;Self Efficacy;Services;shared decision making;Signal Recognition Particle;Site;social cohesion;Soil;Source;superfund site;tool;Training;Translational Research;Trust;Unemployment;web site

PROJECT_TITLE: Core C  Community Engagement (CEC)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Substance Misuse

PI_NAMEs: MCTEAGUE, LISA M (contact)

PROJECT_TERMS: Abstinence;Acceleration;Aftercare;alcohol abstinence;Alcohol consumption;alcohol cue;alcohol exposure;alcohol relapse;alcohol research;alcohol response;alcohol use disorder;Alcohols;Attention;Attenuated;Back;Behavior;Behavior Therapy;Biological Markers;Brain;carbohydrate-deficient transferrin;Clinical;clinical center;Clinical Trials;Controlled Clinical Trials;Corpus striatum structure;craving;cue reactivity;Cues;Double-Blind Method;drinking;efficacy evaluation;Emotional;Enrollment;evidence base;FDA approved;follow-up;Foundations;Functional Magnetic Resonance Imaging;Genetic;Goals;Heavy Drinking;Human;Imaging Techniques;improved;incentive salience;Individual;Informed Consent;innovation;Intake;Interdisciplinary Study;interest;Intervention;Knowledge;Long-Term Depression;Measures;Mediating;Mediator;Mental Depression;Modernization;Motivation;Multi-Institutional Clinical Trial;negative affect;neural circuit;neuroimaging;novel;novel therapeutic intervention;Outcome;Outcome Measure;Participant;Patient Self-Report;Patients;pharmacologic;pre-clinical;pre-clinical research;preclinical study;Prefrontal Cortex;primary outcome;Procedures;Psychotherapy;Publishing;Randomized;randomized placebo controlled study;Relapse;Research;Research Personnel;Research Proposals;response;reward circuitry;Rewards;Seminal;Serum;Signal Transduction;Techniques;Therapeutic;timeline;tool;trait;Transcranial magnetic stimulation;Translating;treatment center;treatment duration;Treatment outcome;Treatment Protocols;treatment response;Urine;Ventral Striatum;Work

PROJECT_TITLE: mPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MCCORMICK, LISA C (contact)

PROJECT_TERMS: Administrator;Alabama;Appointment;Area;Arts;Asthma;Award;Biology;Cellular biology;Chronic Obstructive Pulmonary Disease;clinical center;Clinical Sciences;Collaborations;collaborative environment;college;community health study;Critical Care;Databases;Deep South;Department chair;Development Plans;Disease;Disparity;diversity and inclusion;Doctor of Philosophy;Education;Educational Curriculum;Engineering;Enrollment;Ensure;Environment;Environmental Engineering technology;Environmental Health;Environmental Science;Epidemiologist;Epidemiology;Evaluation;experience;Exposure to;Faculty;faculty mentor;Fostering;Free Radicals;Funding;Future;Gases;Goals;graduate student;Grant;Growth;Health Disparities Research;Health education;Heavy Metals;improved;Individual;Institution;Instruction;Interdisciplinary Study;Investments;Laboratories;Lead;Learning;lectures;Lung;Lung Diseases;Lung infections;Mass Spectrum Analysis;medical schools;Medicine;member;Mentors;Mentorship;Metals;minority disparity;minority health;minority health disparity;Molecular Biology;Monitor;multidisciplinary;National Institute of Environmental Health Sciences;Nature;next generation;occupational health/safety;Pathogenesis;Performance;Physiology;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Process;professor;Program Evaluation;programs;Public Health;Public Health Schools;Publications;quality assurance;recruit;remediation;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Research Training;Resources;Science;Scientist;sensor technology;skills;social;Social Sciences;Structure;Students;success;Superfund;timeline;Toxicology;Training;Training and Education;Training Programs;translational medicine;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Core DResearch Experience Training Coordination (RETCC)


NIH_SPENDING_CATS: Cancer;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE While immunotherapies have transformed cancer treatment strategies, a robust response has not been observed in ovarian cancer. Our studies are geared towards understanding how manipulating sphingosine-1-phosphate (S1P) signaling influences PD-L1 expression, which can be used to produce a favorable immune microenvironment amenable for ovarian cancer immunotherapy.

PI_NAMEs: PRADEEP, SUNILA  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Antibodies;Autologous;Biological Markers;Biological Models;Blood specimen;cancer cell;cancer immunotherapy;Cancer Model;Cancer Patient;cancer therapy;Cell model;Cells;Communication;Cytotoxic T-Lymphocytes;Data;Development;E2F transcription factors;Environment;Event;exhaustion;exosome;extracellular;extracellular vesicles;Functional disorder;Genetic Transcription;Goals;Growth;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune response;immunoregulation;Immunosuppression;Immunotherapy;in vivo;inhibitor;Laboratories;Lipids;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Melanoma Cell;Modeling;Molecular;neoplastic cell;novel;Outcome;ovarian neoplasm;Pathway interactions;patient derived xenograft model;pharmacologic;Phosphorylation;Phosphotransferases;Play;Population;predictive marker;Production;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Proteins;Renal Cell Carcinoma;Research Proposals;response;RNA;Role;Sampling;Serous;Signal Transduction;Sphingosine;sphingosine 1-phosphate;SPHK1 enzyme;success;synergism;T-Lymphocyte;Testing;Therapeutic;treatment strategy;TSG101 gene;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;tumor-immune system interactions;Work

PROJECT_TITLE: Role of exosomal SPHK1 in ovarian cancer progression

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative Mantle cell lymphoma (MCL) is an incurable disease which manifests resistance to both conventional chemotherapy approaches and ibrutinib, a B cell receptor signaling inhibitor. Here we will use primary patient material to prospectively investigate the role of NFκB pathway activation in ibrutinib resistance in MCL. Armed with our preliminary data, we will evaluate a novel strategy to overcome this resistance by targeting the Nedd8- activating enzyme (NAE), by conducting investigations in vitro, in mouse models using ibrutinib-resistant MCL cell lines and patient-derived xenografts, and in a clinical trial of pevonedistat, an investigational inhibitor of NAE.

PI_NAMEs: DANILOV, ALEXEY V. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Affect;Agammaglobulinaemia tyrosine kinase;Age;Aggressive Clinical Course;Apoptosis;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;BCL2 gene;BIRC3 gene;Blood;Bone Marrow;Cell Cycle Proteins;Cell Line;Cell Physiology;Cells;Cessation of life;chemokine;chemotherapy;Chronic;Chronic Lymphocytic Leukemia;clinical translation;Clinical Trials;Cyclin D1;Data;Development;Diagnosis;Disease;Enzyme Inhibition;Enzymes;Evaluation;Exhibits;Failure;Family;Future;Genes;Genetic;Genetic Complementation Test;Genetic Transcription;high-throughput drug screening;Homing;Immune;Immuno-Chemotherapy;immunoregulation;Immunosuppression;In Vitro;in vivo;inhibitor;Investigation;Ligase;lymph node microenvironment;lymph nodes;Lymphoid Cell;Lymphoma;Lymphoma cell;Malignant - descriptor;Mantle Cell Lymphoma;Mediating;mouse model;multicatalytic endopeptidase complex;Mus;Mutation;Neoplasms;neoplastic;neoplastic cell;Newly Diagnosed;Non-Hodgkin's Lymphoma;novel strategies;Nuclear;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;patient derived xenograft model;Patients;Pattern;pharmacologic;Phase I Clinical Trials;phase II trial;Phenotype;Phospholipase;Phosphotransferases;Play;pre-clinical;Prognosis;Progressive Disease;Proliferating;prospective;Prospective Studies;Protein Family;Receptor Signaling;Recurrence;Refractory;Regimen;Regulation;Regulatory T-Lymphocyte;RELA gene;Relapse;Resistance;Resistance development;response;Role;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stromal Neoplasm;synergism;System;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;therapy resistant;Tissues;TRAF2 gene;tumor;tumor microenvironment;Ubiquitin;Ubiquitin-Activating Enzymes;Up-Regulation;Xenograft Model

PROJECT_TITLE: Overcoming ibrutinib resistance in mantle cell lymphoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Bioengineering;Brain Disorders;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Rare Diseases

ORG_NAME: NEW YORK GENOME CENTER

PHR: Project Narrative Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease for which there are no biomarkers and only limited treatments stemming from a poor understanding of its pathogenesis. Here, we propose to integrate novel computational methods with spatially resolved transcriptomic and proteomic analyses of clinically deep-phenotyped postmortem ALS brains and spinal cords to determine the specific molecular correlates of functional impairment in this disease. By integrating these data with WGS and RNAseq data, our ultimate goal is to unveil how disease-associated variants drive specific dysfunction in ALS, which may in turn foster precision medicine-based treatment strategies.

PI_NAMEs: JACKSON, CHRISTOPHER ;PHATNANI, HEMALI  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Address;Age;ALS pathology;ALS patients;Amyotrophic Lateral Sclerosis;Anatomy;Area;associated symptom;Atlases;Autopsy;Bayesian Analysis;Behavior;Biological Markers;Brain;burden of illness;Candidate Disease Gene;Catalogs;cell type;Cells;Clinical;Clinical stratification;Communities;computer framework;Computer Vision Systems;Computing Methodologies;Data;data integration;Data Set;Diagnostic;Disease;Fostering;Functional disorder;Functional impairment;Gene Expression;Gene Expression Profile;Genes;Goals;graph theory;Human;human study;Image;imaging modality;immune imaging;In Situ;Indirect Immunofluorescence;Individual;interest;Knowledge;Link;Localized Disease;Lower Extremity;Machine Learning;Maps;Measurement;Measures;Methods;Modality;Molecular;molecular dynamics;molecular pathology;Motor Cortex;Motor Neurons;mouse model;multidimensional data;multimodality;Multiomic Data;multiple omics;Mus;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;new therapeutic target;novel;novel diagnostics;Onset of illness;Paralysed;Pathogenesis;Pathology;Pathway interactions;patient stratification;Patients;Phenotype;precision medicine;Primary Lateral Sclerosis;protein TDP-43;Proteins;Proteome;Proteomics;Publishing;regional difference;Research Personnel;Resolution;Resources;Sampling;Signal Transduction;single-cell RNA sequencing;Site;Spinal Cord;sporadic amyotrophic lateral sclerosis;stem;symptomatology;Symptoms;Testing;Therapeutic;Time;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomics;treatment strategy;Variant

PROJECT_TITLE: Spatially Resolved Dynamics of Molecular Pathology and Intercellular Interactions in Amytrophic Lateral Sclerosis

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: AMHERST

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE Human cancer is one of the leading causes of death worldwide, a reflection of the fact that the molecular basis of the disease is yet poorly understood. We propose a novel computational strategy to build a cancer progression model using genomic data obtained from excised tumor tissue samples (static data). The delineation of the dynamic disease process and the identification of pivotal molecular events that drive stepwise cancer progression will provide a wealth of new insights into tumor biology and guide the development of improved cancer diagnostics, prognostics and targeted therapeutics.

PI_NAMEs: GOODISON, STEVE ;SUN, YIJUN  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Acceleration;Address;advanced disease;Advisory Committees;anti-cancer research;Automobile Driving;Bioinformatics;bioinformatics pipeline;Biological Process;Breast Cancer Model;breast cancer progression;Cancer Diagnostics;cancer genome;Catalogs;Cause of Death;Clinical;Clinical Management;cohort;Communities;Computer software;Data;Data Set;Development;Disease;Disease Progression;Disease-Free Survival;DNA Sequence Alteration;dynamic system;Economics;Epigenetic Process;Ethics;Event;Evolution;Experimental Designs;Foundations;Genes;Genetic;genetic association;genetic information;Genetic Variation;genomic data;Genomic Instability;Genomics;Human;improved;in silico;indexing;insight;Interdisciplinary Study;Investigation;Investments;Learning;Life;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Methods;Modeling;Molecular;Molecular Profiling;Mutation;Natural Selections;Neoplasm Metastasis;novel;open source;Pathway Analysis;Pathway interactions;Pattern;Predisposition;Primary Neoplasm;Probability;Process;prognostic;Progressive Disease;Research;Resolution;Resources;Role;Sampling;Series;Structure;targeted treatment;Technology;Testing;The Cancer Genome Atlas;theories;Therapeutic Intervention;Time;tissue archive;Tissue Sample;tumor;Tumor Biology;tumor progression;Tumor Tissue;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: Advanced Computational Approaches to Delineating Dynamic Cancer Progression Processes by Using Massive Static Sample Data

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Lung;Prevention

PHR: Project Narrative Inhaled particulate matter containing heavy metals such as arsenic, manganese and cadmium, are known to cause chronic obstructive pulmonary disease (COPD), however the mechanism remains unclear. Residents of an EPA proposed superfund site live close to coke ovens and coal fired power plants in Birmingham, AL and have twice the prevalence of COPD than elsewhere and their lungs demonstrate the presence of abnormal proteins. We will work closely with the EPA and ATSDR in providing information to the community about COPD and about the science that informs our work.

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Address;Affect;airway remodeling;Alabama;Amidines;Area;Arginine;Arginine deiminase;Arsenic;Atmosphere;Biological Markers;bronchiolar fibrosis;Cadmium;Calcium;Cell Physiology;Chronic lung disease;Chronic Obstructive Pulmonary Disease;cigarette smoke;Cities;Citrulline;coal-fired power plant;cohort;Coke;Communities;comparison control;Complex;County;Data;demographics;Development;Dimensions;Disease susceptibility;early detection biomarkers;Environment;Environmental Exposure;Environmental Risk Factor;Enzymes;Exhalation;Exposure to;Fibroblasts;fine particles;Fractals;Genetic;Heavy Metals;Human;In Vitro;Individual;Industrialization;Inhalation;inhibitor;Intermediate Filament Proteins;Lung;Lung Diseases;Macrophage;Manganese;Measurement;Mediating;Metal exposure;mortality;mouse model;Mus;non-smoker;novel;novel therapeutic intervention;Particulate Matter;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphorylation;Physical condensation;Plasma;Pollution;Prevalence;prospective test;Proteins;Pulmonary Emphysema;Reporting;Risk Factors;Role;Science;Site;Smoker;Smoking;smoking prevalence;spheroids;Steel;Structure of parenchyma of lung;superfund site;Testing;therapeutic target;TLR4 gene;tool;Toxic Environmental Substances;Untranslated RNA;Up-Regulation;Validation;Vimentin;Work;X-Ray Computed Tomography

PROJECT_TITLE: Project 1 Heavy Metal Induced Airway Remodeling and COPD


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PI_NAMEs: MULHOLLAND, PATRICK J. (contact)

PROJECT_TERMS: addiction;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol research;alcohol response;alcohol seeking behavior;alcohol use disorder;Alcohols;Area;Attention;Automobile Driving;Basic Science;Behavior;Behavioral;calmodulin-dependent protein kinase II;Cells;Characteristics;Choice Behavior;Chronic;chronic alcohol ingestion;Clinical;Cognition;Cognitive;cognitive function;Consumption;Corpus striatum structure;Cues;Data;design;Development;drinking;drinking behavior;Electrophysiology (science);Emerging Technologies;Ethanol;Female;Fiber;flexibility;functional adaptation;Functional disorder;Genetic;Genetic Recombination;Genetic study;Glutamates;Goals;Health;Heavy Drinking;hedonic;high risk;Individual;inducible Cre;Lateral;Legal;Lesion;Maintenance;male;Measurement;Measures;Medial;Modeling;Monitor;Motivation;Mus;neural;neural circuit;neuroadaptation;Neurons;non-drug;novel;Outcome;Pathway interactions;Pattern;Perception;Performance;Phosphorylation;Photometry;Play;Population;preclinical study;Prefrontal Cortex;problem drinker;Relapse;relapse risk;Research;Research Project Grants;Resistance;Reversal Learning;reward processing;Rewards;Rodent;Role;Signal Transduction;Slice;social;Structure;Tamoxifen;Technology;Testing;Thalamic Nuclei;Thalamic structure;treatment center;Virus;Withdrawal

PROJECT_TITLE: Alcohol Dependence and Loss of Reward-Based Flexible Behavior: Role of Mediodorsal Thalamus to PFC Circuit


NIH_SPENDING_CATS: Asthma;Climate-Related Exposures and Conditions;Clinical Research;Lung;Pediatric

PHR: PROJECT NARRATIVE   Environmental exposure of the lung to airborne mixed heavy metals contributes to development of chronic  lung diseases, including asthma in children. This project will identify novel pathobiologic mechanisms for  airway remodeling and hyper-responsiveness related to heavy metal exposure, and develop new therapeutic  strategies to treat asthma.

PI_NAMEs: DESHANE, JESSY SATYADAS (contact)

PROJECT_TERMS: Affect;Airborne Particulate Matter;airway epithelium;airway hyperresponsiveness;airway remodeling;Animals;Apoptosis;Apoptotic;Area;Arsenic;Asthma;asthmatic;asthmatic airway;Biological Markers;Blood;bronchial epithelium;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Bronchoscopy;Cadmium;Cell Communication;Cell Proliferation;Cells;Cellular Stress;Ceramides;Child;Childhood Asthma;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Communication;Data;demographics;Development;Disease;Environment;Environmental Exposure;Epidemiology;Epithelial Cells;epithelial injury;Epithelium;Equilibrium;exosome;Experimental Models;Exposure to;extracellular vesicles;Fibroblasts;Fibrosis;fine particles;Heavy Metals;Human;In Vitro;Incidence;Individual;Inflammatory;Inflammatory Response;insight;lipid mediator;lipid metabolism;lipidomics;Lipids;Location;Lung;Lung Diseases;Manganese;Mesenchymal;Metal exposure;meter;Mitochondria;mitochondrial dysfunction;Modeling;Mus;novel;novel therapeutic intervention;Particulate;Particulate Matter;Pathogenesis;Pathway interactions;Phenotype;Plasma;Population;pre-clinical;preclinical efficacy;Preclinical Testing;Predisposition;Reporting;Resistance;response;Role;Serum;Severities;Signal Transduction;Smooth Muscle Myocytes;Sphingolipids;Sphingosine;Sputum;superfund site;T-Lymphocyte;Testing;United States Environmental Protection Agency;urinary;Urine

PROJECT_TITLE: Project 2Asthma in Children Exposed to Heavy Metals


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Recent developments in artificial intelligence and neuroscience have revealed neural population codes for reinforcement that represent predictions of a range of potential reward outcomes, rather than a singular expected value. This distributional reinforcement learning has enabled improved performance of artificial agents and has clear implications for human choice behavior and neuropsychiatric disorders. This proposal aims to leverage our experience recording human neuronal activity from the brains of epilepsy patients to begin addressing the novel avenues of research in distributional reinforcement learning. We will determine where distributional codes exist in the human prefrontal and mesial temporal lobes, and how those codes are expressed dynamically in time as humans make impulsive choices and learn reward probabilities. The results of these experiments will have important basic scientific implications and will begin to address how distributional reinforcement learning in the human brain underlies choice behavior that has implications for neuropsychiatric disease.

PI_NAMEs: SMITH, ELLIOT H (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Address;Affect;Amygdaloid structure;analog;Animals;Anterior;Area;Artificial Intelligence;Basic Science;Behavior;Behavior Disorders;Behavioral;Brain;Brain Stem;Categories;Choice Behavior;cingulate cortex;Code;Color;Complex;Corpus striatum structure;Data;Decision Making;Development;Dopamine;Dopamine Receptor;dopaminergic neuron;Epilepsy;Exhibits;expectation;experience;experimental study;Feedback;Future;Goals;Hippocampus;Human;human subject;improved;Impulse Control Disorders;Impulsive Behavior;Impulsivity;Intractable Epilepsy;Knowledge;Learning;learning outcome;Link;Mathematics;Measures;medial temporal lobe;Medical;Mental disorders;Mental Health;Modeling;Monitor;Mus;neural;neuromechanism;Neurons;neuropsychiatric disorder;neuropsychiatry;Neurosciences;neurosurgery;novel;optimism;Organism;Outcome;Patients;Performance;Population;Predictive Value;Probability;Psychiatric therapeutic procedure;Psychological reinforcement;Research;response;Reversal Learning;Rewards;Risk;Role;Signal Transduction;Substance Use Disorder;Temporal Lobe;Testing;Time;Translating;Update;Work

PROJECT_TITLE: The role of distributional reinforcement learning in human neurons during impulsive choices

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Infectious Diseases;Lung

PHR: Residents living near coal fired power plants, coke ovens, or strip mines are often exposed to heavy metals that can cause serious lung diseases, such as recurrent bronchitis and pneumonia. We seek to identify the mechanisms by which heavy metal exposure increase the severity of infections in the lung.

PI_NAMEs: CARTER, A BRENT (contact)

PROJECT_TERMS: Affect;Air;airway remodeling;airway repair;alveolar epithelium;Area;Arsenic;Asthma;asthma exacerbation;Attenuated;Bacteria;Biological Assay;Bronchitis;Cadmium;cell injury;Cells;Chronic lung disease;Chronic Obstructive Pulmonary Disease;cigarette smoke;Coal;coal-fired power plant;Coke;comparison control;Complex;Data;Development;Dextrans;Diagnosis;Disease;Dust;Environment;Environmental Exposure;Epithelial Cells;Exposure to;fighting;Fossil Fuels;Functional disorder;genetic approach;Goals;Half-Life;Heavy Metals;Hospitalization;Host Defense;Human;human disease;Impairment;In Vitro;Incineration;Infection;infection burden;Inflammatory;injured;Injury;injury and repair;Innate Immune Response;Liquid substance;Lower Respiratory Tract Infection;Lung;Lung Diseases;lung injury;Macrophage;Macrophage Activation;Manganese;Mediating;Metal exposure;Mining;Molecular;Morbidity - disease rate;mortality;Municipalities;Mus;Oils;organ injury;Pathogenesis;Pathologic;Permeability;Phenotype;Play;Pneumonia;Recurrence;repaired;Resolution;respiratory health;respiratory pathogen;Respiratory syncytial virus;restoration;Role;Severities;Smoking;Soil;Source;Streptococcus pneumoniae;superfund site;Testing;therapeutic target;Tobacco;Toxic effect;Viral Load result;wasting;wound;wound closure

PROJECT_TITLE: Project 3 Heavy Metals Exacerbate Lower Respiratory Tract Infections


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Combined BET Bromodomain Inhibition (BBDI) and CDK4/6 inhibition demonstrated strong synergism in preclinical models of NUT Carcinoma, an aggressive and rare malignancy with no FDA approved therapy or established treatment regimen. We will conduct a phase 1 clinical trial (NCI Protocol #10509) of the BET inhibitor ZEN003694 plus the CDK4/6 inhibitor abemaciclib in NUT Carcinoma and other solid tumors. Using pre-treatment, on-treatment, and progression biopsies, we will study proof-of-mechanism and biomarkers of response and resistance to combined BET and CDK4/6 inhibition.

PI_NAMEs: CHENG, MICHAEL L. (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Adolescent and Young Adult;Affect;ANXA5 gene;Apoptosis;Area;ATAC-seq;Binding;Biopsy;Biopsy Specimen;Blood specimen;BRD2 gene;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Cancer Therapy Evaluation Program;candidate identification;candidate marker;CDK4 gene;Cell Cycle;Cell Line;Cell Proliferation;Chemotherapy-Oncologic Procedure;Chest;chimeric gene;Chimeric Proteins;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Clinical;Clinical Trials;cohort;combinatorial;Combined Modality Therapy;Correlative Study;Cytotoxic Chemotherapy;design;Detection;Development;Diagnosis;Disease;Dose;Drug Kinetics;exome sequencing;FDA approved;Future;Genomics;Head;Hematologic Neoplasms;Histone Acetylation;histone acetyltransferase;Histones;immunohistochemical markers;inhibitor;Intuition;involucrin;Keratin;Laboratories;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Maximum Tolerated Dose;Neck;novel;Nut carcinoma;Nuts;Oncogenes;Participant;Patients;peripheral blood;Pharmacodynamics;Phase;phase 1 study;Phase I Clinical Trials;phase II trial;Play;Population;potential biomarker;Pre-Clinical Model;Progression-Free Survivals;Proliferation Marker;promoter;Protocols documentation;rare cancer;Recommendation;recruit;Regimen;Research;Resistance;response;response biomarker;Retinoblastoma Protein;Role;S-Phase Fraction;safety assessment;Schedule;Science;Serum;sex;Solid;Solid Neoplasm;Squamous cell carcinoma;Squamous Differentiation;Structure;synergism;Systemic Therapy;thymidine kinase 1;Time;transcription factor;transcriptome sequencing;Translating;Treatment Protocols;treatment strategy;tumor;tumor initiation;Tumor Tissue;tumorigenic;Undifferentiated

PROJECT_TITLE: Combined bromodomain and CDK4/6 inhibition in NUT Carcinoma and other solid tumors


NIH_SPENDING_CATS: Bioengineering;Lung;Social Determinants of Health

PHR: Environmental/Engineering: Project #4. Advanced approaches to quantifying exposure to heavy metals Project Narrative The project focuses at developing portable, cost-effective, sensitive and fast solutions based on novel femto- LIBS/LEAFS and middle infrared frequency comb “Optical Nose” systems for quantifying exposure to heavy metals.

PI_NAMEs: MIROV, SERGEY B (contact)

PROJECT_TERMS: AA Spectrophotometry;absorption;Address;Affect;Air Pollution;Alabama;Area;Biological Markers;Cause of Death;Chemicals;Chromium;Chronic Obstructive Pulmonary Disease;clinical database;coal-fired power plant;Coke;Complex;Confocal Microscopy;cost effective;Coupled;data acquisition;Detection;detection limit;Development;Dust;Elements;Engineering;Environment;Exposure to;Fingerprint;Fluorescence Spectroscopy;Foundations;Fourier Transform;Fourier transform spectroscopy;Frequencies;frequency comb;Gases;Generations;Health;Heavy Metals;High Prevalence;improved;Inductively Coupled Plasma Mass Spectrometry;Inhalation;instrument;laser induced breakdown spectroscopy;Lasers;Light;Liquid substance;Literature;Lung Diseases;lung injury;Measures;Mechanics;Metal exposure;meter;Methods;Microscopic;Mission;Molecular;Molecular Profiling;nanosecond;Neighborhoods;Nose;novel;Optics;Pattern;Performance;Physics;Physiologic pulse;Plasma;Poison;Pollution;portability;Preparation;Prevalence;Procedures;prototype;rapid detection;remediation;Resolution;Risk;Sample Size;Sampling;Series;smoking prevalence;soil pollution;Solid;Spectrometry;Spectrum Analysis;Speed;Steel;System;Techniques;Technology;Time;Transition Elements;Universities;volatile organic compound;Water Pollution

PROJECT_TITLE: Project 4 Advanced Approaches to Quantifying Exposure to Heavy Metals


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Physical Activity;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: KANSAS CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Higher prevalence of obesity increases risk of cancer in rural populations who often lack access to weight control programs, have fewer food and physical built environment resources that promote healthy lifestyles, and limited availability of evidence-based treatment. This study will assess the effectiveness of TelemedTeam, a two-year team-based telemedicine intervention that pairs intensive group telemedicine visits with a lifestyle coach and quarterly team-based clinic visits with the patient, PCP, and telemedicine lifestyle coach. This novel collaborative telemedicine solution combines the benefits of group-based treatment, home-based telemedicine delivery and team-based care integration in local rural clinics, capitalizing on the importance of medical management, and local resources and support networks.

PI_NAMEs: BEFORT, CHRISTIE  (contact)

PROGRAM_OFFICER_NAME: RANDHAWA, GURVANEET

PROJECT_TERMS: Address;Adoption;Adult;Affect;Area;arm;bariatric surgery;Behavior;Behavioral;Body mass index;Body Weight decreased;built environment;Cancer Etiology;cancer risk;cancer type;Cessation of life;Clinic;Clinic Visits;Code;Communities;Commuting;comorbidity;Consumption;County;Data;design;diabetes prevention program;Diet;Disparity;effectiveness evaluation;Energy Intake;Environment;Evaluation;Evidence based treatment;Exercise;experience;Fatty acid glycerol esters;Food;Geography;Guidelines;Health;healthy lifestyle;High Prevalence;High-Risk Cancer;Home;Human Resources;implementation outcomes;Improve Access;improved;Individual;Intervention;Kansas;Knowledge;Life Style;low socioeconomic status;Maintenance;Malignant Neoplasms;Measures;Medical;novel;Obesity;Obesity associated cancer;obesity treatment;obesogenic;Office Visits;Operative Surgical Procedures;Outcome;Participant;patient engagement;patient-clinician communication;Patients;Pharmaceutical Preparations;Pharmacotherapy;Physical activity;Plants;Population;Prediction of Response to Therapy;Prevalence;prevent;Primary Care;primary care clinic;Primary Care Physician;primary care provider;Process;programs;Publishing;Quality of life;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Resources;Risk;Rural;rural Americans;rural area;Rural Community;rural dwellers;rural health clinic;Rural Population;rural setting;secondary outcome;social culture;social disparities;sociodemographic factors;support network;team-based care;Telemedicine;Telephone;Testing;Time;Tobacco;Transportation;treatment as usual;treatment effect;treatment trial;uptake;urban area;Visit;Walking;Weight;weight maintenance;Weight maintenance regimen

PROJECT_TITLE: Rural Engagement in TelemedTeam for Options in Obesity Treatment Solutions (RE-TOOL)


ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE – OVERALL CENTER PAH contamination at over 800 Superfund Sites poses a significant exposure risk to humans and the environment. The Oregon State University Superfund Research Program is developing technologies to understand PAH mixture composition at superfund sites, to predict their toxicity, and to reduce their impacts on the environment.

PI_NAMEs: TANGUAY, ROBYN L (contact)

PROJECT_TERMS: Address;Aromatic Polycyclic Hydrocarbons;Behavioral;Bioinformatics;Biological;Biological Availability;Biomedical Research;Body Composition;Cardiovascular Diseases;Chemical Exposure;Chemicals;Chemistry;Collaborations;Communities;community engagement;Complex;Complex Mixtures;Data;Data Analyses;data management;Devices;Disease;Disease Outcome;DNA Damage;Environment;Environmental Engineering technology;Environmental Health;Environmental Science;experience;Exposure to;frontier;Funding;Gene Expression;Goals;Grant;hazard;Hazard Models;Health;Health Hazards;Human;improved;In Vitro;in vivo;Individual;innovation;instrumentation;Laboratories;Link;Location;Lung;Lung Diseases;Malignant Neoplasms;Measures;Metabolic;Metabolism;Mission;Modeling;Monitor;Movement;multidisciplinary;new technology;next generation;novel;novel strategies;Oregon;Outcome;oxidation;Pacific Northwest;Parents;Predisposition;programs;Property;Quality of life;Recommendation;remediation;Research;Research Project Grants;Research Support;respiratory;Risk;Risk Assessment;Risk Reduction;Sampling;Science;Scientist;Site;Soil;Specific qualifier value;success;Superfund;superfund site;System;Techniques;Technology;Testing;three dimensional cell culture;Time;Tissues;tool;Toxic effect;Toxicity Tests;Training;transcriptomics;Translational Research;Universities;UV Radiation Exposure;wearable device;Work;wristband;Zebrafish

PROJECT_TITLE: PAHs: New Technologies and Emerging Health Risks