ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: TUCSON

ORG_NAME: LIGHT RESEARCH, INC.

ORG_STATE: AZ

PHR: Project Narrative Light Research Inc will develop a compact multimodal intraoral camera with four distinct and complementary imaging modalities for detecting and diagnosis of caries and crack. The novel and unique intraoral camera will enable earlier detection, more accurate diagnosis, earlier application of preventive modalities of treatment, and an overall improvement in the oral health of the public.

PI_NAMEs: WILDER-SMITH, PETRA E (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: accurate diagnosis;Address;Adult;Affect;Algorithms;American;base;Cancer Detection;cancer diagnosis;Child;Clinical;Clinical Research;commercialization;Data Set;deciduous tooth;deep learning;Dental;Dental Care;Dental caries;Dental Offices;Dentists;design;Detection;Developed Countries;Devices;Diagnosis;Diagnostic;Diagnostic Equipment;Diagnostic Imaging;Diagnostic Procedure;digital;Disease;Early Diagnosis;Effectiveness;Fracture;Goals;Health;Health Care Costs;Health Status;human subject;Image;image processing;Imaging Device;imaging modality;imaging Segmentation;imaging software;Imaging Techniques;impression;improved;Incidence;innovation;Light;malignant mouth neoplasm;Manikins;member;microleakage;Modality;Modeling;Monitor;Mouth Diseases;multidisciplinary;Multimodal Imaging;multimodality;novel;Optical Coherence Tomography;optical imaging;Optics;Oral cavity;Oral Diagnosis;Oral health;Outcome;Performance;Periodontal Diseases;permanent tooth;Persons;Phase;Preventive;Prophylactic treatment;prototype;Public Health;Reporting;Reproducibility;Research;Scanning;segmentation algorithm;Sensitivity and Specificity;software development;Structure;Surface;Syndrome;System;Techniques;Technology;Testing;Therapeutic Agents;Tissues;tomography;tool;Tooth Diseases;Tooth Fractures;Tooth Loss;Tooth structure;Transillumination;Validation;Visit;Visual

PROJECT_TITLE: Multimodal intraoral camera

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (10)]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ALBUQUERQUE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on trichloroethylene (TCE), one of the most widely detected chemicals at Superfund sites. Experiments will be conducted to examine how TCE, through its major metabolite, alters gene expression and DNA methylation to drive CD4+ T cell differentiation into pro-inflammatory effector cells. These experiments will help explain how exposure to TCE promotes hypersensitivity and autoimmunity.

PI_NAMEs: BLOSSOM, SARAH J (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Adoptive Transfer;Autoimmune;Autoimmune Diseases;Autoimmunity;bisulfite sequencing;CD4 Positive T Lymphocytes;Cell Differentiation process;Cells;Chemicals;Chronic;Control Groups;cytokine;Dermal;differentiation in vitro;Disease;disorder risk;DNA Methylation;drinking water;Effector Cell;environmental chemical;Environmental Pollutants;Epigenetic Process;Event;experimental study;Exposure to;Female;Flow Cytometry;Gene Expression;Genes;Genetic Predisposition to Disease;genetic signature;genome-wide;Goals;Grant;Half-Life;Human;Hydration status;Hypersensitivity;Immune;Immune response;Immune System Diseases;In Vitro;in vivo;Individual;Industrialization;Inflammatory;inhibitor;innovation;insight;Interferons;Knowledge;Liquid substance;Lupus;lupus cutaneous;lupus prone mice;lupus-like;male;Mediating;Memory;memory CD4 T lymphocyte;Metabolism;Methylation;methylation pattern;Mouse Strains;Mus;Nature;novel;Outcome;Pathogenicity;Pathology;Pathway interactions;Prevention;Process;Production;Promoter Regions;Proteins;Public Health;Research;Resistance;Risk Factors;sex;Solvents;superfund site;T cell differentiation;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Time;Tissues;transcriptome sequencing;trichloroacetaldehyde;Trichloroethylene;Variant;water solubility

PROJECT_TITLE: Epigenetic modulation of CD4+ T cell differentiation and autoimmunity by trichloroethylene

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: This project will leverage data on two cohorts (Medicaid and Medicare enrollees) to characterize the impact of air pollution on risk for and progression of Alzheimer's disease and related dementias (AD/ADRD), and identify the complex interactions of individual-level, environmental and societal factors that lead to increased vulnerability in AD/ADRD. We will develop innovative, transparent, and reproducible methods to address current statistical challenges including outcome misclassification. We will determine the impact of multiple inter-related environmental protective and risk factors to address the multi-factorial AD/ADRD health burden.

PI_NAMEs: ZANOBETTI, ANTONELLA  (contact)

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Acceleration;Address;Age;aging brain;Air Pollution;Alzheimer's Disease;Alzheimer's disease related dementia;Biological;Cause of Death;Cessation of life;cognitive function;cognitive testing;cohort;Cohort Studies;Complex;Computer software;Coupled;Dangerousness;Data;Data Set;Dementia;dementia risk;Disease Progression;Ensure;Environmental Risk Factor;Epidemiology;epidemiology study;Exposure to;Face;fine particles;Foundations;Funding;General Population;Goals;Green space;Health;Health Care Costs;Healthcare;high risk;hospital readmission;Hospitalization;Human;human old age (65+);Impaired cognition;improved;Individual;innovation;Link;Long-Term Effects;Longitudinal cohort;low socioeconomic status;Machine Learning;machine learning method;Medicaid;Medicare claim;Medicare/Medicaid;Methods;mild cognitive impairment;modifiable risk;mortality risk;nanoparticle;Neighborhoods;Nerve Degeneration;Neuroglia;Neurons;Nitrogen Dioxide;Noise;open source;Outcome;Oxidative Stress;Oxidative Stress Pathway;Ozone;Pathologic;Pathway interactions;Peer Review;Persons;Population;prevent;Prevention;protective factors;Publishing;Race;Reproducibility;Research;Research Personnel;response;Risk;Risk Factors;Sample Size;sex;Side;Societal Factors;socioeconomics;Statistical Methods;Subgroup;systemic inflammatory response;Time;Toxicology;United States;United States National Institutes of Health;Update;Weather;weather variables

PROJECT_TITLE: National Cohort Studies of Alzheimer's Disease, Related Dementias and Air Pollution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(55)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: Posttraumatic stress disorder (PTSD) is a disabling, chronic, and costly psychiatric condition that is estimated to occur in 23% of Veterans with recent service in Iraq and/or Afghanistan.1 Although there are available treatments for PTSD, studies suggest that fewer than 10% of Veterans receive the recommended dose of psychotherapy;2-4 moreover, the use of efficacious evidenced-based psychotherapy (EBP) is even lower.5 The role of Veteran and family-level determinants in the initiation and completion of an adequate dose of psychotherapy for PTSD is unclear and without robust evidence, efforts to develop and test strategies to strengthen these determinants will remain limited. The proposed research is highly relevant to Veteran health because it will use novel machine learning approaches to identify these risk-factors and test two innovative approaches to strengthen Veterans determinants of PTSD psychotherapy engagement.

PI_NAMEs: SHEPHERD-BANIGAN, MEGAN ELIZABETH (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Afghanistan;Ambulatory Care Facilities;Area;Award;Behavior;career;Caregiver support;Chronic;Clinical;clinical implementation;clinical practice;Clinical Research;cohort;Collaborations;Complex;Consult;cost;Cox Proportional Hazards Models;Data;Data Collection;design;Development;Diagnosis;Disabling;Doctor of Philosophy;Dose;Economic Factors;Economics;Education;Educational Status;Educational workshop;Effectiveness;Employment;evidence base;Evidence based practice;Family;Family member;family support;feasibility testing;Financial Hardship;forest;Funding;Goals;Health;health care availability;health care delivery;health service use;Health Services;Health Services Accessibility;Health Services Research;Healthcare Systems;implementation efforts;implementation science;improved;Income;Individual;innovation;Intervention;Interview;Iraq;Knowledge;Link;Machine Learning;machine learning method;Maintenance;medical specialties;Mental disorders;Mental Health;Mental Health Services;Mentors;Methods;novel;Patients;poor health outcome;Population Sciences;Post-Traumatic Stress Disorders;Postdoctoral Fellow;programs;Provider;Psychotherapy;Qualitative Research;randomized trial;randomized, clinical trials;Readiness;Recommendation;rehabilitation service;Research;research and development;Research Methodology;Research Personnel;Resources;Risk Factors;Role;Scientist;Self Care;service delivery;Services;skills;social;social factors;Social support;Statistical Methods;Stress;Suicide prevention;Supported Employment;Surveys;symposium;System;Testing;Time;Training;treatment group;Universities;uptake;Veterans;Vocational rehabilitation;Washington

PROJECT_TITLE: Increasing mental health services use through enabling resources & family support

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Immunotherapy;Neurodegenerative;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE We have discovered that microglia play a critical role in compacting and insulating amyloid plaques, which renders them less toxic to adjacent neuronal processes. We are proposing to utilize sophisticated live imaging and high-resolution microscopy combined with molecular manipulations to investigate how microglia interact with another cell type, astrocytes, during the protective encapsulation of amyloid plaques. We hypothesize that coordinated encapsulation by these two glial cells is critical for preventing damage to adjacent axons. We hope that this interaction can be exploited therapeutically to diminish the progression of neural dysfunction in Alzheimer disease.

PI_NAMEs: GRUTZENDLER, JAIME  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: abeta accumulation;Ablation;Affect;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloidosis;anti-PD-1;Apolipoprotein E;apolipoprotein E-3;Apoptosis;Astrocytes;Autopsy;Axon;Brain;cell type;Cells;CRISPR/Cas technology;CTLA4 gene;Cues;Data;Defect;Deposition;Disease;Encapsulated;Exposure to;extracellular;genetic manipulation;genetic variant;Goals;high resolution imaging;Human;human imaging;hyperphosphorylated tau;Image;immune checkpoint;improved;in vivo;in vivo optical imaging;Individual;Inflammatory;Knock-out;Ligands;Mediating;Membrane;Methods;Microglia;Microscopy;Molecular;Molecular Conformation;mouse model;Mus;Neurites;Neuroglia;Neuronal Dysfunction;Neurons;neuropathology;neuroprotection;neutralizing antibody;novel;Optics;overexpression;Pathogenesis;pathological aging;Pathology;Pattern;Pharmacological Treatment;Play;prevent;Process;programmed cell death ligand 1;programmed cell death protein 1;Property;Proteins;Reaction;receptor;reconstruction;Resolution;response;restraint;Role;Senile Plaques;Signal Pathway;Signal Transduction;Structure;superresolution imaging;Surface;Swelling;targeted treatment;Therapeutic;Time;TREM2 gene;two-photon;ultra high resolution;Variant;Viral;Viral Vector

PROJECT_TITLE: Mechanisms of axonal protection by astrocytes and microglia inAlzheimer disease


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: ANN ARBOR

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Protein tyrosine sulfation plays important roles in, e.g., protein-protein interactions, inflammation, and viral infections. Due to the extreme lability of this posttranslational modification (PTM), global liquid chromatography/mass spectrometry analysis has not been feasible to date; however we discovered a novel workflow that partially enables such measurements. Here, we propose new strategies to further enhance detection and allow site determination of this widespread PTM in cells and tissues.

PI_NAMEs: HAKANSSON, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: absorption;Acidity;adduct;Alkanesulfonates;Amino Acids;animal tissue;Anions;Arginine;Basic Amino Acids;Cations;Cell Culture Techniques;Cell division;Cell Physiology;Cell surface;Cells;Charge;chemical property;Chlorates;Collaborations;Complication;Data;data acquisition;Data Analyses;Data Set;Databases;Detection;detection method;Development;Disease;Dissociation;Electron Transport;Electrons;Electrospray Ionization;Environment;Enzymes;Eukaryotic Cell;experimental study;extracellular;Free Radicals;functional group;Gases;glycosylation;Golgi Apparatus;GORASP2 gene;Health;Heparin;hepatoma cell;HIV;improved;Infection;Inflammation;inhibitor;instrument;interest;Interphase;ionization;Ions;knock-down;Knock-out;Laboratories;liquid chromatography mass spectrometry;Liver;Location;Lysine;Manuals;mass spectrometer;Mass Spectrum Analysis;Measurement;Measures;Membrane Proteins;Methods;Mitotic;Modality;multi-photon;Nature;Normal Cell;novel;novel strategies;Organelles;peptide hormone;Peptide Sequence Determination;Peptides;Performance;Phase;Phosphopeptides;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Play;Positioning Attribute;Post Translational Modification Analysis;Post-Translational Protein Processing;prevent;Process;protein protein interaction;Protein Region;Protein Secretion;protein-tyrosine sulfotransferase;Proteins;Rattus;receptor binding;Regulation;Reporting;Retina;Role;rottlerin;Site;Sulfate;sulfotransferase;sulfurtransferase;Suramin;tandem mass spectrometry;Techniques;Technology;Tissues;tool;Trifluoroethanol;Tyrosine;tyrosine O-sulfate;Validation;Vesicle;Viral;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Enabling Mass Spectrometry Analysis of the Sulfoproteome

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Microbiome;Neurosciences;Wound Healing and Care

ORG_CITY: CHARLESTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Serotonin, and specifically serotonin receptor 4 (5-HTR4), has been shown to have reparative effects on skin and colonic wounds; however, the mechanism behind this phenomenon is unclear. Our preliminary data in human intestinal enteroids indicate that 5-HTR4 activation stimulates release of trefoil factor 3 (TFF3) to promote repair in live imaging wound healing assays. Thus, in this proposal we seek to definitively link 5-HTR4 and TFF3 and identify the molecular mechanisms of colonic wound repair in mice and enteroids.

PI_NAMEs: ENGEVIK, MELINDA ANNE (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Actins;Address;Adult;Agonist;Animal Model;Award;Bifidobacterium;Biological Assay;Biopsy;C57BL/6 Mouse;Central Nervous System;Colitis;Collaborations;college;Colon;Colonoscopy;commensal bacteria;Critical Illness;CXCR4 gene;CXCR4 Receptors;Cytoskeleton;Data;Development;Distal;Enterochromaffin Cells;Enterocutaneous Fistula;Epidermal Growth Factor Receptor;Epithelial Cells;epithelial repair;epithelial wound;Epithelium;experimental study;F-Actin;Failure;Filopodia;Foundations;Funding;Future;Gastric ulcer;Gastrointestinal tract structure;Germ-Free;Gnotobiotic;Goals;Goblet Cells;healing;Hospitalization;HTR3A gene;Human;Ileitis;Image;In Vitro;in vivo;Infection;Inflammatory;Inflammatory Bowel Diseases;inhibitor;innovation;Institution;intestinal epithelium;Intestines;K-Series Research Career Programs;Link;Literature;Mediating;Medicine;Mentors;Mentorship;microbial;Microbiology;Modeling;Molecular;monolayer;mouse model;Mucous Membrane;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;novel therapeutics;Ondansetron;Outcome;Peripheral Nervous System;Physiological;prevent;Process;Productivity;Property;Publications;receptor;Recombinants;release factor 3;repaired;Research;Research Personnel;Resources;response;Role;Scientific Advances and Accomplishments;Scientist;Secure;sensor;Serotonin;Serotonin Production;serotonin receptor;Serotonin Receptors 5-HT4;Signal Transduction;Signaling Molecule;Site;Skin;Skin injury;Surgical Anastomosis;Techniques;tegaserod;Testing;Therapeutic Agents;Tissues;Training;trefoil factor;Ulcer;Work;wound;wound closure;wound healing;Wound models

PROJECT_TITLE: Identifying the role of serotonin receptor 4 and trefoil factor 3 in intestinal wound repair

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Complementary and Integrative Health;Infectious Diseases;Natural Products

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Relevance  The development of new treatments for resistant bacterial infections and aggressive cancers is a pressing need for public health. Natural products or their analogs have served as a major source of new classes of drugs over the last century and this proposal targets the study of natural products that have potential to be employed as novel treatments for human disease.

PI_NAMEs: PIERCE, JOSHUA G. (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: analog;antimicrobial;Bacterial Infections;bacterial resistance;bioactive natural products;Biology;chemical reaction;Chemicals;clinically relevant;Complex;Development;Disease;Family;Guanidines;human disease;innovation;interest;Lead;Malignant Neoplasms;Microbial Biofilms;natural antimicrobial;Natural Products;novel;novel drug class;Oxazolidinones;programs;Public Health;Reaction;Research;Source;Synthesis Chemistry;therapeutic development;therapeutic lead compound;United States National Institutes of Health;Work

PROJECT_TITLE: Synthesis and Chemical Biology of Bioactive Natural Products

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative The proposed research is relevant to public health because it addresses gaps in prevention and control of high blood pressures through engagement of trusted community leaders – in this case, by working with highly respected religious leaders in Tanzania. High blood pressure is the leading risk factor for premature mortality worldwide, and is also more common in disadvantaged communities. Therefore, this proposed research is relevant to the NIH’s mission of fostering “innovative research strategies… for ultimately protecting and improving health” and to reducing health disparities, as well as specifically responsive to the NHLBI’s goal of studying implementation strategies to prevent cardiovascular disease.

PI_NAMEs: DOWNS, JENNIFER ALZOS (contact);PECK, ROBERT N

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Address;Adoption;Adult;Africa South of the Sahara;Age;aged;Anti-Hypertensive Agents;Awareness;Behavior;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure intervention;blood pressure reduction;Body Weight decreased;Cardiovascular Diseases;Cardiovascular system;Caring;Cessation of life;clinical care;Cluster randomized trial;Communities;community engagement;Community Health;community intervention;community partners;Creativeness;Data;design;Diagnosis;Diet;diet and exercise;Dissemination and Implementation;Education;Educational Curriculum;Educational process of instructing;effectiveness evaluation;Effectiveness of Interventions;empowerment;evidence base;Exercise;flexibility;Fostering;Goals;good diet;Government;Health;Health behavior;Health Personnel;Health system;Healthcare;Hybrids;Hypertension;hypertension control;hypertension treatment;hypertensive;implementation strategy;implementation/effectiveness;improved;innovation;Institution;Intervention;intervention refinement;Interview;Knowledge;Learning;Life;Maintenance;Male Circumcision;Measures;Medical;meetings;member;men;Mentorship;Methods;Mission;Modeling;modifiable risk;mortality;Muslim population group;National Heart, Lung, and Blood Institute;neighborhood disadvantage;Nonpharmacologic Therapy;novel strategies;Outcome;peer support;Persons;pharmacologic;physical conditioning;pilot test;post intervention;premature;Premature Mortality;Prevalence;prevent;Prevention;primary outcome;Public Health;Publishing;Random Allocation;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reduce health disparities;Religion;Reporting;Research;Risk;Risk Factors;Rural Community;Sampling;screening;secondary outcome;Social Environment;Spirituality;Standardization;Tanzania;Testing;Translating;Trust;United States National Institutes of Health;uptake;Weight;Woman

PROJECT_TITLE: Engaging Religious Leaders to Reduce Blood Pressures in Tanzanian Communities

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Relevance The basal ganglia are implicated in many neurological and psychiatric disorders, such as Parkinson’s disease, Huntington’s disease, and obsessive-compulsive disorder. A better understanding of the mechanisms is critical for therapeutic developments for these disorders. By expanding our knowledge of how basal ganglia outputs generate behavior, the proposed studies can lead to novel treatment strategies for disorders with basal ganglia pathology.

PI_NAMEs: YIN, HENRY  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: 3-Dimensional;Acceleration;autism spectrum disorder;Axon;Basal Ganglia;Behavior;behavior measurement;Behavioral;Brain;Brain region;Calcium;Complex;Corpus striatum structure;Deceleration;Disease;Disinhibition;Dopamine;Event;experimental study;Huntington Disease;Image;imaging modality;in vivo calcium imaging;innovation;kinematics;Knowledge;Measures;Mental disorders;Modeling;Motion;motivated behavior;motor control;mouse model;Movement;Mus;Nature;neglect;Nervous System Disorder;neural;Neurons;novel;Obsessive-Compulsive Disorder;optogenetics;Organism;Output;Parkinson Disease;Pathology;Pathway interactions;Performance;Population;Positioning Attribute;rate of change;Recurrence;Resolution;Rewards;Role;Shapes;Slice;Specific qualifier value;Synapses;Testing;Textbooks;therapeutic development;Time;treatment strategy;vector;Work

PROJECT_TITLE: The Role of Opponent Basal Ganglia Outputs in Behavior

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Knowledge of degradation and antigenic processing of human ZnT8 in pancreatic beta cells will facilitate development of novel therapeutic strategies against both type-1 and type-2 diabetes.

PI_NAMEs: FU, DAX  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Acute;Antigen Targeting;Apoptotic;Autoantibodies;Autoantigens;Autoimmune Diabetes;autoimmune pathogenesis;Automobile Driving;autoreactive B cell;B-Cell Antigen Receptor;Beta Cell;Binding;Biochemistry;Biology;blood glucose regulation;CD8-Positive T-Lymphocytes;Cell Physiology;Cell surface;Cells;Chronic;Client;Clinical;Complex;Coupled;Crystallization;cytokine;cytotoxic CD8 T cells;Dedications;Development;Diabetes Mellitus;diabetes risk;diabetogenic;Disease;Disease Progression;Endocrine;Endoplasmic Reticulum;endoplasmic reticulum stress;Environmental Risk Factor;exome sequencing;Failure;Functional disorder;Genes;Genetic;genome wide association study;Glucose;Goals;Homing;Human;Human body;human population genetics;immune cell infiltrate;immunogenicity;Immunophenotyping;in vivo;Inbred NOD Mice;Inflammation;Inflammatory;Insulin;Insulin Resistance;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;islet autoimmunity;Knowledge;Link;Lipids;loss of function mutation;Mediating;Minor;Modeling;Molecular;molecular recognition;Monoclonal Antibodies;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Pancreas;Patients;Peptides;Phase;Positioning Attribute;Predisposition;Production;protein complex;protein degradation;Protein Dynamics;Proteins;Publications;Regulation;Research;response;Risk;Role;Secretory Vesicles;Serum;Shapes;Solid;Specificity;Stress;Structure of beta Cell of islet;Surface;Susceptibility Gene;targeted treatment;Therapeutic Intervention;Tissues;Tubulin;type I and type II diabetes;ubiquitin-protein ligase;Ubiquitination;Zinc;zinc-binding protein

PROJECT_TITLE: Molecular functions of human zinc transporter-8 in pancreatic beta cells

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Lymphatic Research

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: The proposed studies are relevant to public health because they will inform upon the mechanisms by which RASA1 and EPHB4 regulate the development and function of lymphatic valves. Knowledge gained is expected to inform upon possible means with which to treat lymphatic disorders in patients with inherited mutations in RASA1 and EPHB4 genes. Thus, proposed studies are relevant to the part of the NIH mission that aims to extend healthy life and reduce the burdens of illness and disability.

PI_NAMEs: KING, PHILIP D (contact)

PROGRAM_OFFICER_NAME: GALIS, ZORINA S

PROJECT_TERMS: adaptive immune response;Adult;Apoptosis;Apoptotic;Basement membrane;Biological;biological adaptation to stress;blind;Blood;Blood Circulation;body cavity;burden of illness;Cardiovascular system;Cell Death;cell growth;Cell membrane;Cells;Cessation of life;Chylothorax;Chylous Ascites;Collagen Type IV;Data;Defect;Deposition;Development;disability;Disease;Embryo;Endoplasmic Reticulum;Eph Family Receptors;experimental study;Extravasation;Functional disorder;Funding;Genes;Goals;Growth Factor Receptors;Guanosine Triphosphate;Health;Human;Immunity;Impairment;Inherited;innovation;Intercellular Fluid;Investments;Knowledge;Laboratories;Life;Lipids;Liquid substance;Lymph;lymph flow;lymph nodes;Lymphatic;Lymphatic Capillaries;lymphatic development;Lymphatic Diseases;Lymphatic Endothelial Cells;Lymphatic function;lymphatic valve;lymphatic vessel;Lymphedema;Maintenance;Medical;Methodology;Mission;Molecular;mouse genetics;Mus;Muscle Cells;Mutation;novel;novel therapeutics;Outcome;Pathway interactions;Patients;Physiological;Play;Prevention therapy;Public Health;Ras Signaling Pathway;Receptor Protein-Tyrosine Kinases;Regulation;Reporting;Role;Signal Transduction;Signal Transduction Pathway;System;Testing;Tissues;United States National Institutes of Health;vascular factor;Vascular System;Venous;Vertebrates

PROJECT_TITLE: EPHB4-RASA1 regulation of lymphatic vessel valve development and function

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Obesity

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Obesity, which is prevalent in 40% of American adults, is associated with a greater prevalence of high-risk nocturnal blood pressure (BP) profile, which predisposes them to adverse cardiovascular events. The putative deficiency of natriuretic peptides (NPs) in obese, and the misalignment of the NP-RAAS-BP rhythm axis, may contribute to the high nocturnal BP among obese individuals. The proposed study seeks to determine the biological implications of the 1) NP-RAAS-BP rhythm-axis based chronopharmacotherapy to resynchronize the physiological diurnal rhythms, and 2) NP augmentation to restore the normal diurnal BP profile in obese individuals.

PI_NAMEs: ARORA, PANKAJ  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Adult;adult obesity;Affect;Age;Ambulatory Blood Pressure Monitoring;American;Anti-Hypertensive Agents;arm;Biological;Biological Rhythm;Blood Pressure;blood pressure medication;blood pressure regulation;Body mass index;Cardiac;cardiovascular risk factor;Cardiovascular system;Clinical;Clinical Trials;Diastolic blood pressure;Dilatation - action;Diurnal Rhythm;Dose;Double-Blind Method;eligible participant;Endocrine system;Enrollment;Enzymes;Event;Excretory function;Exhibits;FDA approved;Heart;High Prevalence;high risk;Hormones;Hour;Hydrocortisone;Hypertension;hypertensive;hypertensives;improved;Individual;inhibitor;innovation;Inpatients;medication administration;Melatonin;Natriuresis;Natriuretic Peptides;Neprilysin;obese person;Obesity;Outcome;Outcome Study;Participant;patient oriented;Patients;Pattern;Periodicity;Pharmaceutical Preparations;Phase;Physiological;Play;Population;precision medicine;Prevalence;primary endpoint;Protocols documentation;Race;Randomized;Renin-Angiotensin-Aldosterone System;Rest;Role;secondary endpoint;sex;Sodium;Sodium Chloride;Standardization;Testing;Thinness;Time;trial design;urinary;valsartan;vasoconstriction;Vasodilation;Visit;Work

PROJECT_TITLE: Natriuretic Peptide-Renin-Angiotensin-Aldosterone System Rhythm Axis and Nocturnal Blood Pressure

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Comparative Effectiveness Research;Data Science;Health Services;Heart Disease;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Stroke

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The findings will provide timely evidence to bridge the gaps between clinical trials and everyday practice. The new prediction models, once embedded in a decision aid, will bring personalized outcome estimates to shared decision making to promote evidence-based and patient-centered care. Therefore, the proposed project has great potentials to improve the care for millions of patients with AF at risk for stroke.

PI_NAMEs: NOSEWORTHY, PETER A;YAO, XIAOXI  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adherence;administrative database;Affect;Age;Agreement;antagonist;Anticoagulants;Anticoagulation;Atrial Fibrillation;Big Data;care delivery;Caring;Characteristics;Clinic;Clinical;Clinical Trials;cognitive load;Collaborations;comparative effectiveness study;cost;Data;Data Sources;Decision Aid;Decision Making;design;Devices;Evaluation;evidence base;experience;Face;Future;future implementation;Health system;Hemorrhage;improved;insurance claims;Judgment;Link;machine learning method;machine learning model;Medical Care Costs;Modeling;mortality risk;older adult;Oral;Outcome;outcome prediction;Outcomes Research;patient engagement;Patient-Centered Care;Patient-Focused Outcomes;Patients;personalized approach;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacotherapy;Practice Guidelines;practice setting;predictive modeling;predictive tools;preference;preservation;Preventive treatment;Provider;Race;Recommendation;Research;Risk;Risk Estimate;Risk-Benefit Assessment;routine practice;shared decision making;Signal Transduction;Solid;Stroke;Stroke prevention;stroke risk;Suggestion;Time;tool;Translating;Translations;Variant;Warfarin;web based decision aid

PROJECT_TITLE: Optimizing stroke prevention for older adults with atrial fibrillation: Towards rigorous evaluation and judicious application of a new device

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Narrative The goal of our studies is to identify the molecular mechanisms by which truncated ASXL1 leads to the pathogenesis of myeloid malignancies and identify novel therapeutic targets. This study may lead to identification of therapeutic targets for ASXL1 truncation mutation-mediated myeloid malignancies, thus has great translational impact.

PI_NAMEs: XU, MINGJIANG ;YANG, FENG-CHUN  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acetylation;Affinity;anticancer activity;Behavior;Binding;Biological;Biological Assay;Biological Process;Blood;BRD2 gene;Bromodomain;C-terminal;Cells;ChIP-seq;Chromatin;cohesin;Complex;Data;Development;DNA biosynthesis;Doxycycline;Drosophila genus;Dysmyelopoietic Syndromes;epigenetic regulation;Event;Exhibits;Family;Family member;Frequencies;Gene Expression;gene repression;Genes;Genetic Transcription;genome-wide;Goals;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Homologous Gene;Human;Impairment;in vivo;inhibitor;Knowledge;Lysine;Malignant Neoplasms;Mediating;member;Molecular;mouse model;Mus;Mutation;Myeloproliferative disease;new therapeutic target;novel;Oncogenic;Pathogenesis;Pathologic;Patients;PHD Finger;Phenotype;Physiological;Polycomb;prevent;Prognosis;protein complex;Protein Truncation;Proteins;Proteomics;Regulation;Regulator Genes;Reporting;Role;Sampling;sex;success;targeted treatment;Therapeutic;therapeutic target;therapeutically effective;transgene expression;translational impact;transplant model;tumorigenesis;ubiquitin isopeptidase;Xenograft procedure

PROJECT_TITLE: Role of Asxl1 in normal hematopoiesis and pathogenesis of myeloid malignancies

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Genetics

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: Project Narrative: The ends of chromosomes, called telomeres, play a key role in dictating long term cellular proliferation and genome stability. As a result, altered telomere maintenance can lead to challenges to human health late in life, as well as playing a role in cancer development. This application presents a new model proposing that the machinery that maintains the ends of chromosomes is closely linked to protein complexes that facilitate genome-wide chromosomal replication.

PI_NAMEs: KARLSEDER, JAN  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TITLE: Spontaneous replication fork collapse regulates telomere length homeostasis in wild type yeast

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Although the APOE4 gene, encoding one of the variants of apolipoprotein E, is known to greatly increase the chance of developing Alzheimer's disease (AD), the mechanisms by which APOE4 increases AD risk are not completely understood. We will tackle this highly relevant medical question based on a novel hypothesis that focuses on the unique interaction of APOE4 protein with another AD-relevant molecule, heparan sulfate, a highly bioactive sugar chain present on the surface of microglia. Successful completion of this project will not only provide novel insight into the importance of heparan sulfate in AD, but will also identify the APOE4- heparan sulfate interaction as a promising therapeutic target for reducing AD risk in carriers of the APOE4 gene.

PI_NAMEs: YAMAGUCHI, YU  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Ablation;Affinity;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Amyloid deposition;Animals;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;ATP binding cassette transporter 1;Attention;Behavioral;Binding;Binding Proteins;Brain;Brain Pathology;cationic antimicrobial protein CAP 37;Cell surface;Charge;Cholesterol;cholesterol transporters;Code;Core Protein;Data;Dementia;Development;Excision;Exhibits;experimental study;Extracellular Matrix;functional genomics;Genes;Genetic;genetic association;Genetic Polymorphism;Genetic Risk;genetic risk factor;genomic data;Genomics;glial activation;glycosylation;Goals;Heparan Sulfate Proteoglycan;Heparin;Heparitin Sulfate;Heparitin sulfotransferase;Human;Human Genetics;Immunomodulators;immunoregulation;Impaired cognition;In Vitro;in vivo;insight;Late Onset Alzheimer Disease;Ligands;Link;Lipids;Maintenance;Mediating;Medical;Microglia;Molecular;mouse model;Mus;Mutant Strains Mice;Mutation;Nerve Degeneration;neuroinflammation;Neurons;novel;Pathway interactions;Phenotype;Play;Polysaccharides;presenilin-1;Process;Protein Isoforms;Proteins;receptor;Recurrent disease;Regulation;Relative Risks;Reporting;Research;Research Priority;Resistance;response;Risk;Risk Factors;Role;Senile Plaques;Series;Signal Transduction;sugar;Sulfate;Surface;Synapses;tau Proteins;therapeutic target;TREM2 gene;Variant;Woman

PROJECT_TITLE: Microglial heparan sulfate in the modulation of APOE function and neurodegeneration

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG-R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Eye Disease and Disorders of Vision;Headaches;Migraine;Neurosciences;Pain Research

ORG_CITY: LOS ANGELES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative: Corneal pain is an important mechanism to detect injury or damage, leading to protective responses to limit injury if possible (tearing to remove a foreign object), initiate healing and protect the ocular surface required for clear vision. When maladaptive, corneal pain can be so debilitating as to limit daily function, dramatically reduce quality of life, and cause significant economic burden. The proposed research will elucidate the molecular, cellular, anatomical and neurobiological mechanisms of ocular pain and hypersensitivity including photoallodynia by investigating corneal nerves and their responses in non- human disease models of corneal surface injury/dry eye, allergic eye disease and migraine.

PI_NAMEs: MATYNIA, ANNA  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Ablation;Address;Adult;Affect;Afferent Neurons;Allergic;Anatomy;Autopsy;Bacterial Artificial Chromosomes;behavior measurement;Behavioral;Benzalkonium Chloride;C Fiber;Chemicals;clinically relevant;Cornea;Corneal Diseases;Corneal Injury;Corneal pain;daily functioning;Data;Development;Diphtheria Toxin;Disease;disease model;Drug Delivery Systems;Dry Eye Syndromes;Economic Burden;Exhibits;experimental study;Eye diseases;eye dryness;Goals;healing;Human;Hypersensitivity;Immunohistochemistry;Inflammation;Injury;Investigation;Knowledge;Laser In Situ Keratomileusis;Light;Link;Mechanics;Mediating;melanopsin;Migraine;Modeling;Molecular;morphometry;Mouse Strains;multidisciplinary;Mus;Nerve;Nerve Fibers;nerve supply;neuroadaptation;neurobiological mechanism;Neurobiology;Neurons;Neuropeptides;Nitroglycerin;ocular pain;Ocular Pathology;ocular surface;Operative Surgical Procedures;Optic Nerve;Outcome;Pain;pain perception;Pathway interactions;Photophobia;Population;pressure;Quality of life;Research;Research Priority;response;Retina;Role;Stimulus;Structure of trigeminal ganglion;Surface;Techniques;Testing;Trigeminal System;Vision

PROJECT_TITLE: Molecular, cellular, anatomical and neurobiological investigation of melanopsin-expressing corneal innervation, and its role in pain and photophobia


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: WASHINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project narrative In this proposal, I will use a preclinical rodent model of repeat traumatic brain injury to investigate the hypothesis that synaptic deficits underly retrograde memory and investigate if forgotten memories can be restored by reactivating memory specific neuronal populations (engram neurons). By leveraging novel techniques never done in the TBI field to label engram neurons, I will exploit immunohistochemistry and electrophysiology to explore synaptic modifications in engram neurons and in vivo optogenetics to reanimate forgotten memories. This research is important for our current understanding of how retrograde cognition arises in the repeat head impact brain and will provide me with training to help me achieve my goals of being a physician-scientist who specializes in treatment of mild traumatic brain injury.

PI_NAMEs: CHAPMAN, DANIEL  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Accounting;Acute;Affect;Amnesia;Architecture;Athletic Injuries;Behavior;Bilateral;Brain;Burn injury;Cells;Cellular Morphology;Chemicals;Chronic;Cognition;Cognitive;Cognitive deficits;common symptom;conditioned fear;contact sports;Data;dentate gyrus;Electrophysiology (science);Episodic memory;experience;Exposure to;fear memory;forgetting;Freezing;Frequencies;Functional disorder;Glutamate Receptor;Goals;Grant;head impact;Hippocampal Formation;hippocampal pyramidal neuron;Hippocampus;Human;Immediate-Early Genes;Immunohistochemistry;Impaired cognition;Implant;in vivo;Injury;Label;Learning;Memory;Memory impairment;memory recall;mild traumatic brain injury;military service;Modeling;Modification;mouse model;Mus;N-Methylaspartate;Nervous System Disorder;neural;Neurobehavioral Manifestations;Neurologist;neuronal excitability;Neurons;neuropsychiatry;novel;optogenetics;Parahippocampal Gyrus;Patients;Persons;pharmacologic;Physicians;Physiological;Physiology;Population;pre-clinical;Preparation;Property;receptor function;Research;response;Retrograde amnesia;Rodent;Rodent Model;Scientist;selective expression;Services;Severities;Signal Transduction;skills;Slice;Source;Sports;Structure;subconcussion;Synapses;synaptic function;Techniques;Technology;Testing;Time;Training;transcriptome sequencing;transcriptomics;Transgenic Organisms;Traumatic Brain Injury

PROJECT_TITLE: Interrogating Synaptic Mechanisms Underlying Contextual Fear Conditioning Amnesia in Rodent Model of Highly Repetitive Mild Traumatic Brain Injury


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Alzheimer’s disease (AD) remains a major public health problem with no disease modifying therapies. Converging evidence from human and mouse genetics implicates the gene encoding embryonic ectoderm development (Eed), an essential component of the epigenetic polycomb repressive complex 2 (PRC2), as a regulator of Trem2 signaling in microglia and AD risk. Our goal is to understand the mechanistic link between Eed and Trem2 and in the long term to target these pathways for therapeutics for AD.

PI_NAMEs: GOATE, ALISON M (contact);SCHAEFER, ANNE ;TARAKHOVSKY, ALEXANDER

PROJECT_TERMS: Actins;Address;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Alzheimer's disease therapeutic;Apoptotic;Biochemical;Brain;Catalytic Domain;causal variant;Cell Nucleus;Cell Physiology;Cells;Chemotaxis;Chronic;Complex;Cytoplasm;Cytosol;Data;derepression;Development;Disease;disorder risk;Ectoderm;Embryo;Enhancers;Environment;Epigenetic Process;Etiology;Exhibits;exome sequencing;EZH2 gene;functional genomics;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Epistasis;Genetic study;Genetic Transcription;genome editing;genome wide association study;genomic data;Goals;Hematopoietic stem cells;Histone H3;Histones;Human;Human Genetics;human induced pluripotent stem cells;Immune;Impairment;In Vitro;in vivo;induced pluripotent stem cell;Inflammatory;Knockout Mice;Link;loss of function;loss of function mutation;Lysine;Macrophage;Maps;Mediating;Microglia;Missense Mutation;monocyte;mouse genetics;mouse model;Mus;mutant;Myelogenous;Myeloid Cells;Nerve Degeneration;neuroinflammation;neuroprotection;novel;Nuclear;Onset of illness;Pathway interactions;Phagocytosis;pharmacologic;Phenocopy;Phenotype;Play;Polycomb;polymerization;Polymers;prevent;Process;Proliferating;Public Health;receptor;response;risk variant;Role;Signal Induction;Signal Pathway;Signal Transduction;Signaling Protein;Stimulus;Testing;Therapeutic;therapeutic target;tissue stress;TREM2 gene;Variant;whole genome;Xenograft procedure

PROJECT_TITLE: Neuroprotective signaling and transcriptional pathways in microglia associated with Alzheimer's disease


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Jupiter

ORG_NAME: MAX PLANCK FLORIDA CORPORATION

ORG_STATE: FL

PHR: Project Narrative Despite years of study, we do not understand the developmental mechanisms that are responsible for bringing together the inputs from the two eyes to create a single coherent cortical representation of stimulus features. The proposed experiments will provide new insights into the synaptic basis for binocular integration, and the underlying developmental mechanisms that guide this alignment process—insights that are critical for addressing numerous visual, neurological, and psychiatric disorders that are grounded in cortical circuit dysfunction.

PI_NAMEs: FITZPATRICK, DAVID  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Architecture;area striata;Award;Calcium Signaling;Cells;Chronic;Contralateral;Dendritic Spines;Development;Electron Microscopy;Electrophysiology (science);Exhibits;experience;experimental study;Eye;Ferrets;Functional disorder;Goals;hippocampal pyramidal neuron;Image;Imaging Techniques;in vivo;in vivo calcium imaging;in vivo imaging;Individual;insight;Ipsilateral;Left;Mammals;Maps;mature animal;Mental disorders;Microscopy;monocular;Motion;Nature;Nervous System Disorder;neural;Neurons;new technology;orientation selectivity;Output;Pattern;Perception;Photic Stimulation;postnatal development;preference;Process;Property;response;Role;Sensory;Source;Spatial Distribution;Stimulus;Structure;Synapses;Testing;Thalamic structure;two-photon;Vision Disorders;Visual;Visual Cortex;visual neuroscience;Visual Perception;visual stimulus;Visualization;Work

PROJECT_TITLE: Organization and Development of Functional Maps in Visual Cortex

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: RNA helicases are enzymes that rearrange RNA structures in all living cells, from bacteria to humans. Misregulation of the RNA helicase DDX5 results in human pathologies including cancer and metabolic disorders. This research aims to uncover the biochemical and biological function of this enzyme as a central tenet to human disease intervention.

PI_NAMEs: TRAN, ELIZABETH J (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 3' Untranslated Regions;Address;Bacteria;Biochemical;bioinformatics tool;Biological Assay;Biological Models;Biological Process;Biology;cancer type;Cells;chromatin remodeling;Code;Cues;Data;Defect;Disease;DNA;Double-Stranded RNA;Enzymes;Epigenetic Process;Event;Funding;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;genome-wide;genome-wide analysis;Genomic Instability;Goals;helicase;Homeostasis;Human;human disease;Human Pathology;Hybrids;In Vitro;in vivo;innovation;interdisciplinary approach;Intervention;Kinetics;Knowledge;Laboratories;Link;Malignant Neoplasms;malignant neurologic neoplasms;Maps;member;messenger ribonucleoprotein;Metabolic;Metabolic Diseases;mutant;Mutation;Nervous System Disorder;novel;nucleic acid structure;Nutrient;Nutritional status;Pathway interactions;Process;Production;protein complex;Proteins;Publishing;Regulation;Regulator Genes;Reporter;Research;response;RNA;RNA Helicase;RNA helicase A;RNA Polymerase II;Role;Saccharomyces cerevisiae;Series;Structure;Techniques;Testing;Transcript;transcription termination;Transcriptional Regulation;transcriptome sequencing;Untranslated RNA;Virus Diseases;Work;Yeasts

PROJECT_TITLE: The Role of DEAD-box Proteins in Gene Expression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGB-P(07)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Our ability to rapidly and effortlessly categorize incoming stimuli is an essential cognitive process that allows us to interpret the meaning of incoming stimuli in our environment and plan appropriate responses—abilities that are disrupted or impaired by a number of brain diseases and conditions including Alzheimer’s disease, autism, schizophrenia, stroke, and attention deficit disorder. Here, we propose to study how neuronal dynamics across oculomotor brain areas are coordinated to achieve categorization and rapid decision making. We argue that developing a detailed understanding of the neuronal mechanisms underlying visual categorization and category-based decision making will enable a new generation of treatments for the cognitive and perceptual impairments that accompany such diseases and conditions.

PI_NAMEs: ZHU, OU  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Agonist;Alzheimer's Disease;Animals;Area;Arousal;Attention;Attention Deficit Disorder;autism spectrum disorder;Behavior;Behavioral;Brain;Brain Diseases;Brain region;Categories;Cognitive;cognitive process;Coupled;Decision Making;design;Disease;Dissociation;Environment;Evolution;experimental study;frontal eye fields;Generations;Human;Impairment;Individual;information model;insight;Judgment;Laboratories;Lateral;lateral intraparietal area;Macaca mulatta;Measurable;Measures;Methodology;millisecond;Modeling;Monkeys;Motion;Motor;Muscimol;Nervous System Disorder;neural;neural correlate;Neurons;novel;oculomotor;Performance;pharmacologic;Play;Population;Population Dynamics;Population Heterogeneity;Primates;Process;Psychophysics;Reaction Time;receptive field;Research;Resolution;response;Role;Saccades;Schizophrenia;Sensory;sensory discrimination;sensory stimulus;Signal Transduction;Speed;Stimulus;Stroke;Structure;superior colliculus Corpora quadrigemina;System;Tennis;Time;Visual;visual motor;visual stimulus;Visuospatial;With laterality;Work

PROJECT_TITLE: Neuronal encoding of rapid categorical decisions across primate oculomotor networks


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Principal Investigator: Wu, Xiaohua Investigating DNA double-strand break repair mechanisms in mammalian cells Project Narrative  Gross chromosomal rearrangement (GCR) is a hallmark of cancer cells, and DNA double- strand breaks (DSBs) are a major source of GCR. Given that microhomology sequences are often present at chromosomal rearrangement junctions in cancer, and repetitive sequences constitute about half of the human genome, it is important to understand the mechanisms underlying microhomology-mediated end joining and recombination at repetitive sequences. Our research in this proposal will create new knowledge and insight on DSB repair mechanisms in mammalian cells and shed light on how genome instability is induced upon DNA damage and during the oncogenic process.

PI_NAMEs: WU, XIAOHUA  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Biological;cancer cell;cancer genetics;Chromosomal Breaks;Chromosomal Rearrangement;coping;DNA Damage;DNA Double Strand Break;Double Strand Break Repair;Equilibrium;Genetic Diseases;Genetic Recombination;Genomic Instability;human disease;Human Genome;insight;Knowledge;Malignant Neoplasms;Mammalian Cell;Mediating;Oncogenic;Other Genetics;Pathway interactions;prevent;Principal Investigator;Process;repaired;Repetitive Sequence;Reporter;Research;Role;Sequence Homology;Source;Stress;System;Variant

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Successful completion of the proposed research will lead to a detailed understanding of how serine integrases carry out recombination between DNA attachment sites with high specificity and directionality. These enzymes have significant roles in human health through their effects on microbial communities and are used in a variety of genome engineering and synthetic biology applications, including targeted integration of transgenes into eukaryotic cells. This project will provide the groundwork necessary to engineer serine integrases for improved and perhaps novel functions in the biomedical research community.

PI_NAMEs: VAN DUYNE, GREGORY D (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Affinity;analytical ultracentrifugation;Antibiotic Resistance;bacterial community;Bacteriophages;Binding;Binding Sites;Biochemistry;Biological Assay;Biological Models;Biomedical Research;C-terminal;Cells;Chromatin;Chromosome Pairing;Chromosomes;cofactor;Coiled-Coil Domain;Communities;Complex;DNA;DNA Sequence;Elements;Engineering;Enzymes;Eukaryotic Cell;Excision;Family;Foundations;functional improvement;Gene Rearrangement;Genetic Recombination;Genome engineering;gut microbiota;Health;Homeostasis;Human;human disease;improved;Integrase;Kinetics;Lead;Mammalian Cell;microbial community;microbiological attachment sites;Modeling;mutant;novel;Nucleic Acids;pathogen;Pathway interactions;Play;Population;prevent;Proteins;Reaction;Regulation;Research;resistance gene;Resolution;Role;Serine;Site;Specificity;stoichiometry;Structure;synthetic biology;Technology;Testing;tool;Transgenes;Viral;viral DNA;Viral Genome;Virus Integration;Work;X ray diffraction analysis

PROJECT_TITLE: Serine integrase mechanisms and applications

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Aging;Cannabinoid Research;Chronic Pain;Clinical Research;Pain Research;Therapeutic Cannabinoid Research

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE Older adults represent a fast-growing segment of medical marijuana (MM) users in this country, with chronic pain as the most cited reason for use. There is a critical need to systematically examine MM’s short- and long- term effects on the core outcomes of chronic pain including pain intensity, physical, emotional, and cognitive functioning, and overall quality of life, and to track its side effects in older adults. This will be the first prospective cohort study that innovatively combines technology-based ecological momentary assessments (EMA) and in-person visits over 12 months to obtain both subjective and objective data on MM’s short- and long-term effects on older adult with chronic pain.

PI_NAMEs: WANG, YAN  (contact)

PROJECT_TERMS: Address;Anxiety;Biological;Biological Aging;Biological Markers;Cell Aging;Cellular Phone;Characteristics;Chemicals;chronic pain;cognitive change;cognitive function;comparison group;Country;Data;Data Analyses;disability;Dose;Drops;Ecological momentary assessment;emotional functioning;Ensure;Environment;Equilibrium;Expectancy;fitbit;Florida;Goals;Guidelines;Health Benefit;health related quality of life;improved;improved outcome;in vivo;Individual Differences;innovation;Length;Life;Long-Term Effects;male;Marijuana;marijuana use;marijuana user;Measurement;Measures;medical examination;Medical Marijuana;Medical Records;Mental Depression;mobile computing;novel;older adult;Outcome;Pain;Pain intensity;pain reduction;Pain Research;patient subsets;Patients;Pattern;Persons;Phenotype;Physical activity;Physical Function;Physicians;Prospective cohort;Prospective, cohort study;protective factors;Psychological Factors;Quality of life;randomized trial;recruit;Research;Resources;response;Route;Sampling;Sativex;sensor;sex;side effect;Sleep;Social Desirability;Source;success;Surveys;Technology;telomere;Telomere Shortening;Testing;Time;Visit;wearable sensor technology

PROJECT_TITLE: Real-Time and Long-Term Effects of Medical Marijuana on Older Adults: A Prospective Cohort Study

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Infectious Diseases;Malaria;Neurodegenerative;Neurosciences;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

PHR: Project Narrative The goal of the proposed research is to evaluate whether an admission electroencephalogram (EEG) is a diagnostic and prognostic biomarker for Malawian children with fever and coma. We will evaluate whether EEG can differentiate whether coma with fever is due to malaria or from another source. We will evaluate whether there are EEG factors that can be used to predict outcomes in children with coma and fever who do not have malaria parasites in their blood, just as we did in previous research studies of children with cerebral malaria.

PI_NAMEs: POSTELS, DOUGLAS  (contact)

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Acute;Address;Admission activity;adverse outcome;Africa;African;Area;Blood;Brain Edema;brain magnetic resonance imaging;Cerebral Ischemia;Cerebral Malaria;Cerebrum;Cessation of life;Child;Child Care;Childhood;Clinical;clinical care;clinical diagnosis;co-infection;Coma;comorbidity;Complement;Computer software;Country;Critical Illness;Data;diagnostic biomarker;Diagnostic tests;Diffuse;Disease;Electroencephalography;Encephalitis;Encephalopathies;Enrollment;Erythrocytes;Etiology;Fever;Goals;high risk;Hospitals;Human;Intervention;Investigation;Laboratories;Malaria;malaria infection;malaria transmission;Malawi;Meningitis;Methods;Modality;Non-Convulsive Status Epilepticus;Observational Study;Outcome;outcome prediction;Parasitemia;Parasites;Pathogenesis;Patient Care;Patients;Pattern;Plasmodium;Prognostic Marker;Research;research study;Resources;respiratory;Role;Seizures;Sepsis;Source;Status Epilepticus;Symptoms;Time;venule;Viral Encephalitis

PROJECT_TITLE: Evaluating EEG as a diagnostic and prognostic biomarker in Malawian children with febrile coma

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Pediatric;Primary Health Care

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Chronic care models (CCM) that deliver evidence-based practices (EBP) by multidisciplinary teams can improve children’s early behavioral health, but efforts to transport them to pediatric practice – such as our simplified cross-diagnosis CCM protocol for child behavior problems and ADHD (Doctor Office Collaborative Care; DOCC; MH064372) – often face scientific, technical, and practical challenges. Given promising findings by our team showing that such obstacles can be overcome to enhance EBP implementation by applying external and internal facilitation augmentation strategies applied to care teams (TEAM) and leaders (LEAD), respectively, we propose to conduct a hybrid Type 3 effectiveness-implementation trial to test the main and interactive effects of these TEAM and LEAD implementation conditions on provider uptake and clinical outcomes, and to test for their target engagement/mediation and moderation. By proposing one of the first large pragmatic pediatric trials of a CCM-based EBP to address these aims in response to RFA-MH-18-701 and the NIMH’s Strategic Plan (4.2), this research will advance the implementation science knowledge needed to optimize promising strategies for promoting the delivery and scale-up of DOCC in a pediatric medical home.

PI_NAMEs: KOLKO, DAVID  (contact)

PROGRAM_OFFICER_NAME: FREED, MICHAEL C

PROJECT_TERMS: Academy;Acceleration;Address;Adopted;Adult;American;Attention deficit hyperactivity disorder;Attitude;behavioral health;behavioral impairment;care providers;Caregivers;Caring;Case Manager;Child;Child Behavior;Childhood;chronic care model;Clinical;Clinical Trials;Cluster randomized trial;collaborative care;Collection;comorbidity;Competence;Data;design;Diagnosis;effectiveness outcome;effectiveness/implementation trial;evidence base;Evidence based practice;Face;Family;Health Personnel;health record;Home;Hybrids;implementation barriers;implementation intervention;implementation outcomes;implementation science;implementation strategy;improved;Intervention;Knowledge;Leadership;Learning;Manuals;Measures;Mediating;Mediation;Mediator;Medical;Mental Health;Meta-Analysis;Minority;Modeling;multidisciplinary;National Institute of Mental Health;novel;Outcome;patient centered medical home;Patient-Focused Outcomes;pediatric patients;Pediatrics;Pennsylvania;Prevalence;Primary Care;Primary Care Physician;primary care practice;Problem behavior;Problem Solving;programs;Protocols documentation;Provider;Psychiatrist;Public Health;Quality of life;Randomized;Replicating Effective Programs;Research;Resources;response;Sampling;scale up;Schedule;Science;Services;Severities;Strategic Planning;supportive environment;Symptoms;System;Teenagers;Testing;theories;Training;Training Programs;uptake;videoconference;Work

PROJECT_TITLE: Care Team and Practice Level Implementation Strategies to Optimize Pediatric Collaborative Care: A Cluster-Randomized Trial


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Precision Medicine;Prevention;Rare Diseases;Stomach Cancer

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  Gastric cancer is a major cause of cancer related death worldwide and screening practices are not routine in the US, leading to late diagnosis and poor outcomes. To improve accurate diagnoses and medical intervention, different types of metaplasia need to be molecularly defined and the inflammatory signals that trigger development of potentially high-risk metaplastic cells need to be established. The proposed research aims to define types of metaplasia that 1. Arise in models of Helicobacter pylori (Hp) infection compared to models of autoimmune gastritis (AIG), 2. Arise in human Hp compared to AIG patients, and 3. Are selectively induced/expanded by inflammatory cytokines, to ultimately improve methods in gastric cancer early detection and prevention.

PI_NAMEs: HOFT, STELLA GARDEN (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: accurate diagnosis;Adenocarcinoma;Affect;Animals;atopy;Autoimmune;autoimmune gastritis;Autoimmunity;Bacterial Infections;Biopsy;Cancer Burden;Cancer Etiology;cancer subtypes;Cells;Cessation of life;Chronic;Chronic Gastritis;Classification;Complex;cytokine;Cytokine Signaling;cytotoxic;Cytotoxin;Development;Diagnosis;Disease;Disease Progression;Epithelial Cells;Equation;Etiology;Gastric Adenocarcinoma;gastric carcinogenesis;Gastric Metaplasia;Gastritis;Gene Expression Profile;Genetically Engineered Mouse;Goals;Helicobacter Infections;Helicobacter pylori;high risk;Human;human disease;human tissue;Hypersensitivity;IL4R gene;improved;Individual;individualized medicine;Infection;Inflammation;Inflammatory;innovation;insight;Interleukin-13;Interleukin-4;Intervention;Knowledge;Malignant Neoplasms;malignant stomach neoplasm;Medical;MEKs;Metaplasia;Metaplastic Cell;Methods;Modeling;Molecular;Molecular Analysis;molecular phenotype;Molecular Profiling;molecular subtypes;mortality;mouse model;Mus;new therapeutic target;novel;novel therapeutic intervention;Oncogenic;Outcome;Pathologic;Patients;Phenotype;Precancerous Conditions;Predisposition;premalignant;Prevention;Prevention strategy;programs;receptor;Recombinants;Reporting;Research;Resolution;response;Risk;Risk Factors;risk stratification;screening;Screening for Gastric Cancer;Severities;Signal Induction;Signal Pathway;Signal Transduction;single-cell RNA sequencing;spasmolytic polypeptide;Stomach Neoplasms;surveillance strategy;survival outcome;targeted treatment;Testing;Therapeutic Intervention;Tissue Sample;Tissues;transcriptomics;treatment strategy;tumor progression;Work

PROJECT_TITLE: Defining Inflammatory Triggers that Induce Diverse Subtypes of Gastric Metaplasia


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases

ORG_DEPT: SURGERY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The proposed research is relevant to public health because a biostable polymeric valved conduit that can be implanted surgically to reconstruct the right ventricular outflow tract in neonates and infants and then expanded by successive transcatheter procedures to reach the adult size, would revolutionize how we treat children with heart valve diseases. Such a new generation of valved conduit would decrease the number of open-heart surgeries and reoperations, decrease the mortality, complications and healthcare costs related to these procedures and increase the life expectancy and quality of life of these patients. Thus, this proposal is relevant to the part of NIH's mission that pertains to fostering innovative research strategies as a basis for ultimately protecting health.

PI_NAMEs: KALFA, DAVID  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Acceleration;Acute;Adult;Aorta;Area;Biodegradation;biomaterial compatibility;Bioprosthesis device;calcification;Cardiac;Cardiac Surgery procedures;Child;Childhood;Competence;Computer Models;computer scientist;congenital heart abnormality;cytotoxicity test;Data;design;Development;Devices;Diameter;Engineering;Equilibrium;Extracellular Matrix;fabrication;Failure;Fatigue;Fostering;Future;Generations;Goals;Growth;Health Care Costs;Health protection;Heart Valve Diseases;Heart Valves;Height;hemodynamics;Implant;implantable device;implantation;In Vitro;in vivo;Infant;Inflammation;innovation;Length;Life Expectancy;Liquid substance;Maintenance;manufacture;Measures;mechanical properties;Mechanics;Membrane;Methodology;Mission;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Neonatal;neonate;Operative Surgical Procedures;Outcome;Patients;Performance;Physiologic pulse;Polymers;Polytetrafluoroethylene;preclinical study;pressure;Procedures;Process;Property;Prosthesis;prototype;Public Health;Quality of life;Rattus;repaired;Repeat Surgery;Research;Research Personnel;residence;Risk;Scanning Electron Microscopy;Scientist;Sheep;sheep model;skills;Spectroscopy, Fourier Transform Infrared;Stress;Stretching;Structure;subcutaneous;Surgeon;Surgical Valves;Techniques;Testing;Thick;thrombotic complications;Time;Tissue Engineering;Tube;United States National Institutes of Health;Universities;Validation;Ventricular

PROJECT_TITLE: An expandable polymeric valved conduit to repair congenital heart disease

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Natural Products

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Development of novel drugs can address antimicrobial resistance and emerging infectious diseases such as Ebola or COVID-19. Oxidative methods are central to the synthesis of novel scaffolds that will become the next- generation of drugs, therefore the development of enzymatic oxidation methods of small molecules will allow for sustainable and streamlined access to diverse building blocks necessary for the synthesis of pharmaceutical agents that can be used to treat diseases and improve human health. In addition, the proposed method will allow for oxidation of existing pharmaceutical agents making a greater number of molecules that could become effective drugs with changes in the solubility, polarity, duration of effect, oral availability, metabolic stability, and binding affinity in enzyme active sites.

PI_NAMEs: CHAMPAGNE, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: 3-Dimensional;Acceleration;Active Sites;Address;Affinity;Amino Acids;Antimicrobial Resistance;Binding;Biological;Breathing;catalyst;Chemicals;Communicable Diseases;Complex;computerized tools;COVID-19;Data;Databases;Derivation procedure;Development;Disease;Docking;Drug resistance;Ebola;Electronics;Emerging Communicable Diseases;Enzymes;Family;Flavins;Health;Human;Hydroxylation;improved;Indoles;Investigation;Left;Libraries;Logic;Mediating;Metabolic;method development;Methodology;Methods;Mixed Function Oxygenases;Natural Products;Nature;next generation;non-Native;novel;novel therapeutics;Oral;Oxidants;oxidation;Pharmaceutical Preparations;Pharmacologic Substance;Phenols;Positioning Attribute;predictive modeling;Property;pyridine;Reaction;Research;Route;scaffold;screening;Sequence Alignment;Sequence Analysis;Site;small molecule;Solubility;Substrate Interaction;Techniques;tool;trend;Visualization

PROJECT_TITLE: Development of Selective Oxidative Biocatalytic Methods


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE  We have discovered that the same principles that cause mixtures of oil and water to spontaneously separate into distinct liquid `droplets', known as phase separation, play a key role in how genomes are organized and regulated. Here we propose to advance our basic knowledge of how phase separation and other biophysical mechanisms and properties organize and regulate a mysterious part of our genomes, known as heterochromatin. Ultimately, we expect that the results of these and related studies will have enormous impact on our understanding of the causes of human diseases such as dementia and cancer, and could generate novel and effective approaches to their diagnosis and treatment.

PI_NAMEs: KARPEN, GARY H (contact)

PROJECT_TERMS: 3-Dimensional;Address;Aging;Animals;Architecture;Binding;Biochemical;bioimaging;Biological;Biology;Biophysical Process;biophysical properties;biophysical techniques;Biophysics;Cells;Centromere;chemical property;Chromatin;Chromosome Pairing;Complex;Congenital Abnormality;Dementia;Diagnosis;DNA Repair;experience;Foundations;Gene Expression;Gene Silencing;Genetic Transcription;Genome;Genome Stability;Genomic Instability;Goals;Health;Heterochromatin;heterochromatin-specific nonhistone chromosomal protein HP-1;Histone H3;human disease;Image;Immobilization;in vivo;innovation;interdisciplinary approach;Knowledge;Liquid substance;Lysine;Malignant Neoplasms;Membrane;Methylation;novel;novel strategies;Nuclear;Oils;Phase;Physical condensation;Play;Property;Proteins;Publishing;recruit;repaired;System;Testing;Water

PROJECT_TITLE: Interplay Between Nuclear Organization and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE A healthy retina relies on the proper function of the blood-retina barrier, i.e., the interface between blood vessels and retina that mediates highly selective transport of nutrients, hormones, and metabolic waste. Multiple retinal diseases are associated with blood-retina barrier dysfunction. Here, we will use cell-based systems and mouse models to determine the mechanism of action and efficacy of a novel drug candidate that promotes blood-retina barrier function.

PI_NAMEs: ANGERS, STEPHANE ;JUNGE, HARALD  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Active Biological Transport;Agonist;angiogenesis;Anti-Inflammatory Agents;Antibodies;beta catenin;bevacizumab;Biological;Blood;Blood Vessels;Blood-Retinal Barrier;Cells;Characteristics;Choroidal Neovascularization;Coats' disease;Complex;Data;Defect;density;Development;Diabetic Retinopathy;Disease;disease model;drug candidate;efficacy evaluation;Endothelial Cells;experimental study;Extravasation;Familial exudative vitreoretinopathy;Fluorescence Microscopy;Functional disorder;functional mimics;Genes;Growth Factor;Hormones;Human;Human Engineering;Immune;Impairment;In Vitro;in vivo Model;Inflammation;Investigation;Knowledge;Laboratories;Learning;Ligands;lipoprotein receptor related protein 5;Low Density Lipoprotein Receptor;macula;macular edema;Maintenance;Mediating;Metabolic;Modality;Modeling;mouse model;Mus;Nature;novel;novel therapeutic intervention;novel therapeutics;Nutrient;Nutritional Requirements;Pathogenicity;Pathologic;Pathway interactions;Patients;Pericytes;Permeability;Pharmaceutical Preparations;Pharmacodynamics;Population;prevent;Proliferating;Proteins;receptor;Resistance development;response;restoration;Retina;Retinal Diseases;Retinopathy of Prematurity;Side;Signal Induction;Signal Transduction;single molecule;solute;Structure-Activity Relationship;System;Telangiectasis;Testing;Therapeutic;transcriptomics;Translating;Uveitis;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascular Permeabilities;Vascularization;virtual;wasting;WNT Signaling Pathway;WNT7A gene

PROJECT_TITLE: Investigation of a first-in-class Frizzled4/LRP5 agonist in retinal disease models

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: EAST LANSING

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative: Nut Carcinoma (NC) is an aggressive cancer with no effective treatment. We will build a genetically engineered mouse model of NC that will transform understanding of early-stage NC and potentially other cancers caused by NUTM1 gene fusions. The results of our studies will also contribute significant insights needed to develop effective NC treatments without intolerable side effects.

PI_NAMEs: GU, BIN  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Address;Animal Model;Auxins;B-Cell Leukemia;Bromodomain;Cancer Etiology;Cell Culture System;Cell Line;cell type;Cells;Chimeric Proteins;Chromosomal translocation;Chromosomes;Clinical;Clinical Research;Clinical Trials;clinically relevant;Complex;cytotoxic;Development;drug candidate;Drug Targeting;Ectopic Expression;effective therapy;Effectiveness;Engineering;Environment;experimental study;fusion gene;Future;Gene Fusion;Genes;Genetic Models;Genetically Engineered Mouse;genome editing;genomic data;Genomics;Human;In Vitro;in vivo;in vivo imaging;in vivo Model;innovation;insight;Knowledge;Link;male;Malignant Epithelial Cell;Malignant Neoplasms;Methods;Modeling;mouse model;Mus;Mutation;Neoplasms;Normal Cell;novel strategies;Nuclear Protein;Nut carcinoma;Oncogenic;Patients;Physiological;Population;pre-clinical;progenitor;Property;protein degradation;Proteins;Recurrence;Reporter Genes;Research;Resources;side effect;small molecule;Solid Neoplasm;stem;System;targeted treatment;Technology;Testing;Testis;therapeutic development;Time;Tissues;tool;Toxic effect;Transgenic Mice;treatment strategy;tumor;tumorigenesis;women patients

PROJECT_TITLE: Developing a clinically-relevant genetically engineered mouse model for Nut carcinoma


NIH_SPENDING_CATS: Cancer;Lymphatic Research;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Current therapies for vascular malformations are not curative and patients often experience recurring disease and relapses. We can advance our knowledge of these difficult-to-treat diseases by studying vascular malformations with a known genetic mutation like Kaposiform Lymphangiomatosis (KLA) that affects children and young adults. The objective of this application is to perform studies that will give vital insights into the disease process so we can close the knowledge gap of how a recently identified genetic mutation drives the disease process in KLA patients and identify new drug targets.

PI_NAMEs: LE CRAS, TIMOTHY DAVID (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: 3-Dimensional;Abdomen;Affect;Angiogenic Factor;Angiopoietin-2;Antibodies;autocrine;Automobile Driving;Biological Assay;Biological Markers;Biopsy;Blood;Blood Coagulation Disorders;Blood Vessels;Cardiac;Cells;Cellular Morphology;Characteristics;Chemicals;Chest;Child;Clinical;Clinical Trials;Complex;Cyst;Cytoplasm;Cytoplasmic Granules;Data;Diagnosis;Diet;Disease;DNA Sequence Alteration;Doxycycline;effusion;Endothelial Cells;Erythrocytes;experience;Experimental Models;feeding;Film;FRAP1 gene;Functional disorder;Genetic;Goals;Hand;Hemorrhage;Hemosiderin;Histology;Histopathology;Human;Image;Implant;In Vitro;in vitro Model;in vivo Model;inhibitor;insight;Invaded;Knowledge;Laboratories;Left;Lesion;Liver;Lung;Lymphangiogenesis;Lymphangiography;Lymphangiomatosis;Lymphatic;lymphatic malformations;lymphatic vessel;Magnetic Resonance Imaging;malformation;Malignant Neoplasms;Manuscripts;MAP Kinase Gene;Measures;Mediating;Mediator;MEKs;Melanoma;migration;Modeling;Molecular;Morbidity - disease rate;Morphogenesis;mortality;mTOR Inhibitor;Mus;mutant;Mutation;Neuroblastoma;new therapeutic target;novel therapeutics;Organ;overexpression;paracrine;Pathogenesis;Pathway interactions;Patients;Phosphotransferases;PIK3CG gene;Pleural;Pleural effusion disorder;Positioning Attribute;Pre-Clinical Model;Process;Proliferating;Proteomics;Proto-Oncogene Proteins c-akt;Pulmonary artery structure;Radiology Specialty;Recurrent disease;Regulation;Relapse;response;Retroperitoneal Space;Risk;Role;Shapes;Signal Pathway;Signal Transduction;Sirolimus;small hairpin RNA;soft tissue;Somatic Mutation;Spindle Endothelial Cell;Spleen;Stains;Structure;subcutaneous;Symptoms;Tail;TEK gene;Testing;Tissues;transcriptome sequencing;United States National Institutes of Health;Veins;Xenograft Model;Xenograft procedure;young adult

PROJECT_TITLE: Pathogenesis and Treatment of Kaposiform Lymphangiomatosis

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Intraocular inflammation (uveitis) is poorly-understood, difficult-to-treat, and responsible for up to 25% of cases of legal blindness. Treatment options are limited by an incomplete understanding of the molecular causes of the disease. Studies of inherited Calpain-5 uveitis (ADNIV) and the newly-identified Calpain-5 substrate, Iroquois-3, promise to provide key insights into molecular pathways driving uveitis.

PI_NAMEs: BASSUK, ALEXANDER G;MAHAJAN, VINIT B (contact)

PROJECT_TERMS: Affect;Age;Amino Acids;Animals;Automobile Driving;autosome;Binding;Biochemical;Biological Assay;Blindness;C-terminal;Calcium;Calpain;Cell Death;Cell Fractionation;Cell Nucleus;Cells;Co-Immunoprecipitations;Cyclic Peptides;cytokine;Cytoplasm;Data;Disease;DNA;Excision;experimental study;Extracellular Space;Eye;Eye diseases;Fibrosis;functional genomics;Gene Expression;gene network;Genes;Genetic;genetic approach;Genetic Transcription;Goals;Histology;Hyperactivity;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Inherited;inhibitor;Injections;innovation;insight;Interleukin-6;Knockout Mice;Knowledge;Legal Blindness;legal cases;legally blind;Mass Spectrum Analysis;Modeling;Molecular;Molecular Genetics;mouse model;Mus;mutant;Mutation;N-terminal;neovascular;new therapeutic target;novel;novel therapeutics;Nuclear;Ocular Physiology;Pathway interactions;Peptide Hydrolases;Peptides;pharmacologic;Phenocopy;Phenotype;Physiological;Prevalence;promoter;Proteins;Reporter;Research;Resistance;Retina;Role;Severities;Site;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;transcription factor;Uveitis;Work

PROJECT_TITLE: Inflammatory Gene Transcription in the Retina


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE  The rising prevalence of nonalcoholic fatty liver disease (NAFLD) has become a major public health concern. Our proposed studies aim to understand the molecular mechanism of a new form of NAFLD identified from mouse forward genetic screen. This research will have the potential to reveal novel therapeutic targets to reduce NAFLD.

PI_NAMEs: ZHANG, ZHAO  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: adenoviral mediated;Alleles;Body Weight;Characteristics;chronic liver disease;Cirrhosis;combat;Coupling;Data;Development;Diet;dietary;Disease;disease model;disease phenotype;Energy Metabolism;Enzymes;experimental study;Family;fatty acid oxidation;Fatty Liver;Future;Genes;Genetic;Genetic Screening;Genetic Transcription;Genetic Variation;Germ-Line Mutation;glucose metabolism;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Hepatic;Hepatocyte;High Fat Diet;Homologous Gene;Human;Hydroxysteroids;In Vitro;inducible gene expression;insight;Insulin;Insulin Resistance;Interferon Type II;Interferons;Knock-in Mouse;Knock-out;Knowledge;lipid biosynthesis;lipid metabolism;Lipids;Liver;Location;LoxP-flanked allele;Maps;Mass Spectrum Analysis;Meiosis;member;Metabolic;Missense Mutation;Molecular;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Names;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel strategies;novel therapeutic intervention;Obesity;overexpression;oxidation;Oxidoreductase;Pathogenesis;Pathway interactions;Pattern;Phenotype;Physiological;Prevalence;prevent;Primary carcinoma of the liver cells;Process;Promoter Regions;Proteins;Proteomics;Public Health;Regulation;Research;Role;screening;Series;Severities;Slice;Testing;Time;Tissues;transcription factor;Transcriptional Regulation;Translating;Weight Gain;Work

PROJECT_TITLE: The Role of Gm4951 in Nonalcoholic Fatty Liver Disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: PROJECT NARRATIVE Despite the tremendous therapeutic potential of mRNA lipid nanoparticle vaccines, their utility in geriatric treatments is limited because we currently lack robust age-related data to advance treatment methods. This proposal will determine the effect of age on the process of lipid nanoparticle-mediated mRNA delivery as it relates to changes in biological barriers. Results will decouple age-related reductions in mRNA delivery from impaired immune responses and enable nanoparticle formulation or dosing changes to maximize prophylactic outcomes in the elderly.

PI_NAMEs: ARRAL, MARIAH  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: 2019-nCoV;Affect;Age;age difference;age effect;age group;age related;age related changes;Aging;Antibody Response;Antibody titer measurement;Biodistribution;Biological;Biological Assay;Cells;Circulation;Clinical;clinically significant;Communicable Diseases;cytokine;Data;design;Development;dosage;Dose;Ebola;efficacy evaluation;Elderly;Enzyme-Linked Immunosorbent Assay;Epidemic;experience;fighting;Flow Cytometry;Foreign Bodies;Formulation;global health;Goals;Healthcare;human old age (65+);Immune;immune activation;Immune response;Immune system;Immunity;immunogenic;immunogenicity;Immunologics;Immunology;immunosenescence;Impairment;improved;in vivo imaging;infection rate;innovation;Intramuscular;Intramuscular Injections;Kinetics;lipid nanoparticle;Measures;Mediating;Memory;Memory B-Lymphocyte;Messenger RNA;Methods;Modeling;mRNA delivery;Mus;nanoparticle;nanoparticle delivery;nanoprocess;next generation;old mice;Outcome;Ovalbumin;pandemic disease;Patients;Performance;Persons;Pharmaceutical Preparations;Physiological;Population;Positioning Attribute;Predisposition;Process;prophylactic;Proteins;Recording of previous events;Reporter;Research;Research Personnel;response;RNA vaccination;RNA vaccine;Serology;sex;Structure;Subgroup;System;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;Toxic effect;Toxicology;Transfection;uptake;Vaccination;vaccination outcome;vaccine development;vaccine efficacy;vaccine immunogenicity;Vaccine Production;vaccine response;Vaccines;vaccinology;Variant;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Effects of Age on Lipid Nanoparticle Delivery and mRNA Vaccination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-F(20)]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Obesity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: EDINBURG

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

PHR: PROJECT NARRATIVE Type 2 diabetes (T2D) is a global public health problem, with staggering rates of disease evidenced in the US and throughout both developed and developing nations. T2D disparately affects minority populations, with Hispanics being one of the highest at-risk populations. Evidence from both epidemiological and lipidomic studies have shown that specific lipids and their constituent components are important factors in the development of T2D. The human lipidome is made up of thousands of different lipid species, the simpler constituent components of classical lipid measures like HDL. By focusing on biologically simple lipid species, we hope to more rapidly identify genes influencing lipid variation and T2D. We will use whole genome sequencing to identify novel genes underlying the relationship between human lipid variation and T2D in extended pedigrees of Mexican American individuals, and functionally assess identified targets. This approach may lead us to the identification of potential drug targets relevant for lipid modifying therapy.

PI_NAMEs: CURRAN, JOANNE E. (contact);MEIKLE, PETER JOHN

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Affect;African American population;Age;Apolipoproteins B;Behavioral;Biological;Blindness;C-Peptide;causal variant;Cells;Characteristics;Cholesterol;Chromosome Mapping;cohort;Complex;Cost of Illness;Data;design;Developing Countries;Development;Diabetes Mellitus;diabetes risk;Disease;disease phenotype;Disease susceptibility;disorder risk;Drug Targeting;Economic Burden;endophenotype;Epidemic;Epidemiology;epidemiology study;ethnic minority population;Ethnic Origin;Family Study;fasting glucose;Fatty Acids;gene discovery;Genes;Genetic;genetic analysis;Genetic Markers;genetic pedigree;genetic variant;Genetic Variation;genome sequencing;Genomics;Genotype;health disparity;hearing impairment;heart disease risk;Heritability;Heterozygote;High Density Lipoproteins;Hispanic Americans;Hispanic Populations;Human;impaired glucose tolerance;Impairment;Individual;induced pluripotent stem cell;Insulin;Insulin Resistance;insulin secretion;Kidney Diseases;Kidney Failure;Life Style;limb amputation;lipid metabolism;lipidome;lipidomics;Lipids;Lipoproteins;Low-Density Lipoproteins;Lower Extremity;Measures;Metabolic;Metabolic Diseases;Metabolic syndrome;Methods;Mexican Americans;Minority Groups;Modification;Neuropathy;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;particle;Pathogenesis;Pathology;Pathway interactions;Persons;Phenotype;Phospholipids;Plasma;Population;Populations at Risk;Predisposing Factor;Predisposition;Prevalence;Prevention;Proinsulin;Proteins;Public Health;Quantitative Genetics;Quantitative Trait Loci;Risk;Risk Factors;Sampling;Sequence Analysis;sex;Stroke;success;Testing;Tissues;trait;Triglycerides;United States;validation studies;Variant;variant of interest;Visit;whole genome

PROJECT_TITLE: Assessing the Influence of the Human Lipidome on Risk of Diabetes in a Minority Population

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ORG_CITY: STILLWATER

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: Project Narrative/Public Health Relevance Statement The future of medicine depends on the ability to access organofluorines, arduous, if not impossible synthetic targets. In addition, better tools to better understand key biological systems are needed so that the medicinal developments can begin. This project seeks to develop new resources and innovative strategies for organofluorine synthesis, and tools for understanding biological systems, together enabling the future development of medicine.

PI_NAMEs: WEAVER, JIMMIE DEAN (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Contra-Thermodynamic Catalysis and Fluorine Sculpting; Two Counter Cultural Approaches to Synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_NAME: PURDUE UNIVERSITY

PHR: Project Narrative Our perception of pitch is not only important for listening to and creating music, but also for communication and processing the complex sounds that surround us. However, our neurophysiological understanding of pitch processing and how it is degraded with hearing impairment is limited. The proposed study utilizes a cross-species approach to characterize deficits in pitch coding and perception that occur due to various forms of cochlear damage, which will advance our understanding of the physiological bases for individual differences in the perception of every-day sounds with sensorineural hearing impairment.

PI_NAMEs: SIVAPRAKASAM, ANDREW  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustic Nerve;Acoustic Trauma;Adult;Affect;Age;American;Anatomy;animal data;Animal Model;Animals;Auditory;Auditory system;base;behavior measurement;Behavioral;Biological Assay;Categories;cell injury;cellular transduction;Chinchilla (genus);clinical predictors;clinically relevant;Cochlea;Cochlear Hearing Loss;Cochlear Nerve;cochlear synaptopathy;Code;Communication;Complex;Cues;Data;design;Diagnosis;Diagnostic;Differential Threshold;Discrimination;ear muscle;Electrophysiology (science);Emotions;Experimental Designs;experimental study;falls;Frequencies;Functional disorder;Hair Cells;Health;Hearing;hearing impairment;Human;human data;human subject;Impairment;improved;Individual;Individual Differences;individual variation;Inner Hair Cells;innovation;insight;Intuition;Investigation;Knowledge;Laboratories;Link;Literature;Measures;middle age;middle ear;Modeling;Music;Nerve Fibers;Nervous System Disorder;neural;neural correlate;Neurological Models;neurophysiology;normal hearing;otoacoustic emission;Outcome;Outer Hair Cells;Pathology;Pathway interactions;Pattern;Perception;Periodicity;Peripheral;Physicians;Physiological;Physiology;Pitch Discrimination;Pitch Perception;Play;Process;Protocols documentation;Psychoacoustics;Recording of previous events;Reflex action;Research;Research Training;response;Role;Scientist;Self-Help Devices;Sensorineural Hearing Loss;skills;sound;Statistical Models;Stimulus;Synapses;synaptic function;Synaptic Transmission;Tail;Techniques;Testing;theories;Time;Treatment Protocols;Variant;Voice;Work

PROJECT_TITLE: Place and Time Processing of Pitch in the Context of Cochlear Dysfunction


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative Attention deficit hyperactivity disorder (ADHD) affects about 5% of adults [1] and children [2] in the United States, reducing their quality of life and imposing a substantial burden on the economy [3]. Better understanding of basic neuronal mechanisms related to attention and their interaction with sensory signals is needed for enhancing human performance and for guiding assessment, diagnosis and treatment of deficits of attention. The proposed research will investigate how attention affects visual processing in the nervous system, and in particular how distinct control signals related to attention are distributed to different regions of the visual system.

PI_NAMEs: MAUNSELL, JOHN H.R. (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Adult;Affect;area V4;Arousal;Attention;Attention deficit hyperactivity disorder;attentional control;Attentional deficit;Behavior;Behavioral;Brain;Brain region;Cerebral cortex;Child;Data;Diagnosis;Dimensions;Disease;Electrodes;Electrophysiology (science);experimental study;frontal eye fields;Human;Human Activities;Implant;insight;Investigation;Joints;locus ceruleus structure;Maps;Measures;Mediating;Methods;Monkeys;Nervous System;Neurobiology;Neurons;neurophysiology;neurotransmission;Noise;optogenetics;Perception;Performance;Play;Prefrontal Cortex;Quality of life;Research;response;Role;selective attention;Sensory;Signal Detection Analysis;Signal Transduction;Specificity;Stimulus;Structure;Study Subject;superior colliculus Corpora quadrigemina;Techniques;temporal measurement;United States;Visual;Visual attention;visual control;visual performance;visual processing;visual stimulus;Visual System;Visuospatial;Work

PROJECT_TITLE: Neurophysiological circuits underlying visual attention