NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

PHR: PROJECT NARRATIVE Photoreceptor cell death is the ultimate cause of vision loss in many retinal disorders, including inherited retinal degenerations, retinal detachment, and non-exudative age-related macular degeneration. Vision loss patients experience secondary to such retinal disorders results in life-long clinical care, loss of productivity for patients and caregivers, and reduced quality of life. This project will provide necessary career skills to investigate how retinal bioenergetic resources maintain photoreceptor metabolism, function, and viability in health and disease and whether these resources can be leveraged therapeutically to prevent vision loss in blinding eye disease.

PI_NAMEs: WUBBEN, THOMAS JOSEPH (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Acute;Aerobic;aerobic glycolysis;Age related macular degeneration;Amino Acids;Apoptosis;Bioenergetics;Biomass;Blindness;Budgets;Carbon;career development;Caregivers;Catabolism;Cell Death;Cell Line;Cell Physiology;Cell Survival;Cessation of life;Citric Acid Cycle;clinical care;Complement;conditional knockout;Consumption;Crowding;Data;deprivation;Development;Development Plans;Disease;Electroretinography;Environment;Enzymes;Equilibrium;experience;Eye diseases;Faculty;Generations;Genes;Glucose;glucose metabolism;Glutamates;Glutaminase;Glutamine;Glutathione;Goals;Health;Histology;Homeostasis;Hypoxia;improved;In Vitro;in vivo;inherited retinal degeneration;insight;Institution;International;knock-down;Knockout Mice;Label;Laboratories;Link;Lipids;Maintenance;Malignant Neoplasms;Mentors;Mentorship;Metabolic;Metabolism;metabolomics;Methodology;Michigan;Modeling;multidisciplinary;Mus;NADP;neoplastic;neuroprotection;Nitrogen;Nonexudative age-related macular degeneration;novel therapeutics;Nucleic Acids;Nucleotide Biosynthesis;Nutrient;Nutrient availability;nutrient deprivation;Ophthalmology;Optical Coherence Tomography;Oxidation-Reduction;Oxidative Stress;Patients;photoreceptor degeneration;Photoreceptors;Phototransduction;Physiology;prevent;Principal Investigator;Process;Production;productivity loss;Professional Competence;Pyruvate;Quality of life;Reactive Oxygen Species;Research;Research Personnel;Research Proposals;Resources;response;Retina;Retinal Detachment;Retinal Diseases;retinal rods;Role;Scientist;Secondary to;skills;Source;stable isotope;Stress;success;Testing;Therapeutic;Tissues;Tracer;Universities;vision science;Work

PROJECT_TITLE: Glutamine as an alternative fuel source for photoreceptors


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

ORG_CITY: LOUISVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative The ability to judge the locations of various objects from oneself during self-motion in the intermediate distance range (~2-25m) is crucial for successful performance of activities of daily living, such as walking and driving. However, little is known about the mechanisms of visual space perception involved in judging distance, the focus of this project, in the planning and/or execution of self-motion in the natural 3D environment. The theoretical knowledge to be gained from this project will contribute to the scientific literature and provide insights into how eye and neurological defects could impair visual space perception, wayfinding, and mobility.

PI_NAMEs: HE, ZIJIANG  (contact);OOI, TENG LENG

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Address;Adopted;Affect;Attention;Automobile Driving;Behavioral;behavioral response;Characteristics;Code;Cognitive;cognitive load;Complex;Cues;Darkness;Defect;Environment;experimental study;Eye;Human;Image;insight;Judgment;Knowledge;Literature;Location;Maps;Measures;Memory;Motion;motor control;Movement;neural;Neurologic;neuromechanism;operation;Outcomes Research;Performance;phenomenological models;Positioning Attribute;Poverty;Process;Proprioception;Psychophysics;Research;Resources;retinal imaging;Role;Route;Short-Term Memory;Signal Transduction;somatosensory;Space Perception;Surface;System;Testing;Texture;Update;vestibular system;Vision;Visual;visual coding;Visual impairment;visual information;Visual Perception;Visual System;Visuospatial;Walking;way finding

PROJECT_TITLE: Visual mechanisms of intermediate distance space perception during self-motion


ADMINISTERING_IC: AR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Chronic Pain;Genetics;Neurosciences;Pain Research

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PI_NAMEs: MILLER, RICHARD J (contact)

PROJECT_TERMS: Acceleration;Adoption;Afferent Neurons;Anatomy;Animals;Area;Behavior assessment;Brain;Brain imaging;Calcium;cell type;Cells;Central Nervous System;Chicago;chronic pain;Collaborations;Communities;Consultations;Core Facility;Data Analyses;Development;Electrophysiology (science);Evaluation;experience;Fostering;Functional Magnetic Resonance Imaging;Funding;Future;ganglion cell;Genetic;Genetic Transcription;Goals;Human;Image;Immunohistochemistry;In Situ Hybridization;in vivo calcium imaging;innovation;insight;International;Joints;Knee;Label;Laboratories;Leadership;Learning;Light;Methods;Microscopy;Modeling;Monitor;Mus;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal Pain;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Needs Assessment;nerve supply;Neuroanatomy;Neurobiology;neuromechanism;Neurons;Neurosciences;new technology;new therapeutic target;optogenetics;Pain;Pain Research;pain signal;Pathway interactions;Peripheral Nervous System;Physiological;Physiology;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;prevent;programs;Publications;Qualifying;Reporter;Research;Research Personnel;Research Support;Resources;Rheumatism;Running;Services;single-cell RNA sequencing;Spinal Ganglia;Surveys;synergism;Technical Expertise;Techniques;Technology;tissue culture;tool;Training;transcriptome sequencing;Translations;Universities;validation studies;web portal;Work

PROJECT_TITLE: Neurobiology Core C


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The gastrointestinal tract and kidneys provide respectively about 200 and 350 square meters of body surfaces to the outside world - by far the largest surfaces in the body. The FAIR DOs program will educate the next generation of researchers in using the latest computational tools to study transport processes across these crucial surfaces. The use of FAIR methods will also ensure that students appreciate the importance of open science, data sharing, standardization and large-scale collaborative modeling efforts.

PI_NAMEs: BORON, WALTER F;MARTONE, MARYANN E (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Arts;Autonomic nervous system;Award;Basic Science;Biomedical Engineering;Biophysics;Body Surface;Boron;British;California;Clinic;college;Computer Models;computerized tools;Data;data resource;Data Set;data sharing;Department chair;Development;Doctor of Philosophy;doctoral student;Ecosystem;Education;education research;education resources;Educational process of instructing;Engineering;Ensure;Enteric Nervous System;Epithelial Cells;Epithelium;experience;Faculty;FAIR principles;Feedback;Fostering;Future;gastrointestinal;Gastrointestinal tract structure;Hour;Information Networks;Infrastructure;infrastructure development;Institution;International;Journals;Kidney;Knowledge;Knowledge Management;Leadership;Learning Module;lectures;Link;Literature;Maps;Marketing;mathematical model;Medical;medical schools;Medical Students;Mentors;meter;Methodology;Methods;Modeling;models and simulation;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Nervous System Physiology;Neurobiology;neuroregulation;next generation;open data;Outcome;Paper;Peer Review;Physiological;Physiological Processes;Physiology;Population;programs;Publications;Publishing;recruit;renal epithelium;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;response;Schools;Science;Seasons;simulation;Site;Standardization;Structure;Student recruitment;Students;Surface;System;Testing;Textbooks;Training;Transport Process;Universities;Validation;Work;Writing

PROJECT_TITLE: FAIR DOs: Findable, Accessible, Interoperable, Reusable Development of Open Simulation


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: IOWA CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: OVERALL COMPONENT PROJECT NARRATIVE Cystic fibrosis (CF) is a common life-shortening genetic disease that causes progressive lung failure due to recurrent infections and airway obstruction. These studies will use airway cells and cystic fibrosis animal models to investigate new therapeutic strategies to complement CF defects, including gene repair and the addition of a small molecule anion channel. Through these studies we hope to accelerate the development of new therapeutics for CF lung disease. ! !

PI_NAMEs: MCCRAY, PAUL B (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Acceleration;Address;Adenine;adeno-associated viral vector;Airway Disease;airway epithelium;airway obstruction;airway surface liquid;Amphotericin B;Animal Model;Anions;antimicrobial;Apical;Bacteria;base editing;base editor;Bicarbonates;Biology;cell type;Cells;cellular targeting;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Creativeness;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis airway epithelia;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Deaminase;Defect;Development;Disease;DNA;Epithelial Cells;Family suidae;Ferrets;Formulation;gain of function;gene discovery;gene repair;gene replacement;gene therapy;Genetic Diseases;Genetic Engineering;Goals;Guide RNA;Host Defense;Human;In Vitro;in vivo;Infrastructure;innovation;Ion Channel;Knowledge;Life;loss of function;Lung;Lung Diseases;lung failure;Mediating;Missense Mutation;Modeling;Molecular;Morbidity - disease rate;mortality;Mucociliary Clearance;Mutation;Natural Immunity;Nebulizer;novel therapeutic intervention;novel therapeutics;Nucleotides;null mutation;overexpression;Pathogenesis;Peptides;Persons;prevent;Prevention;progenitor;Property;protein function;Proteins;Pulmonary Cystic Fibrosis;Records;recurrent infection;repaired;Research;Research Personnel;Ribonucleoproteins;RNA Splicing;Role;Services;Site;small molecule;Surface;Techniques;Testing;tool;Variant;Work

PROJECT_TITLE: Molecular Therapies for Cystic Fibrosis Lung Disease

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(MA)]


NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Rare Diseases

PROJECT_TERMS: Administrative Personnel;Annual Reports;Biometry;Cardiovascular system;college;Complex;Core Facility;Fostering;Funding;Goals;Grant;Human Resources;Iowa;Leadership;Medicine;meetings;Molecular;Preparation;Program Research Project Grants;programs;Progress Reports;Pulmonary Cystic Fibrosis;Research;Research Design;Research Personnel;Role;Statistical Methods;Travel;United States National Institutes of Health;Universities;Visit

PROJECT_TITLE: Administration Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


PI_NAMEs: ZABNER, JOSEPH  (contact)

PROJECT_TERMS: airway epithelium;biobank;bioelectricity;Biological Models;Cell Culture Techniques;Cell Line;cell type;Cells;Collaborations;Cultured Cells;Cystic Fibrosis;cystic fibrosis airway;Data;Development;Educational process of instructing;Electrophysiology (science);Epithelial Cells;Epithelium;Evaluation;experimental study;Family suidae;Ferrets;Fibroblasts;Flow Cytometry;Functional disorder;Gene Expression Profile;gene therapy;Generations;Goals;Health;Human;human model;human tissue;In Vitro;in vitro Model;Institution;investigator training;Iowa;Methodology;Methods;Mission;Modeling;Molecular;Morphology;Mutation;Persons;Phenotype;porcine model;Process;Production;Pulmonary Cystic Fibrosis;rare variant;Records;Research;Research Personnel;Resources;Services;Study models;Technical Expertise;Tissues;Universities

PROJECT_TITLE: In Vitro Models and Cell Culture Core


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Cystic Fibrosis;Digestive Diseases;Liver Disease;Lung;Pediatric;Rare Diseases

PI_NAMEs: STOLTZ, DAVID A (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Airway Disease;airway inflammation;animal care;Animal Model;Animals;autosome;Biliary cirrhosis;Biological;Blood;Bronchoalveolar Lavage Fluid;Caring;Cell Culture Techniques;Collaborations;Consultations;Cystic Fibrosis;cystic fibrosis mouse;Cystic Fibrosis Transmembrane Conductance Regulator;Disease;Disease Progression;Ensure;Exocrine pancreas;experience;Family suidae;Ferrets;Gallbladder;Genes;Genetic Engineering;Goals;Harvest;health assessment;Human;Human Resources;improved;in vitro Model;Infection;Intestinal Obstruction;Intestines;Knowledge;Liver;Lung;Male Genital Organs;Measures;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;Mouse Strains;Mutation;Neonatal lung;Organ;Pancreas;Pancreatic Diseases;Pathogenesis;Pathology;Patients;Prevention;Production;Program Research Project Grants;programs;Pulmonary Cystic Fibrosis;reproductive tract;Research Personnel;Respiratory Tract Infections;sample collection;Sampling;Sinus;small molecule;Structural defect;success;Sweat Glands;Time;Vas deferens structure

PROJECT_TITLE: Animal Models Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Cancer risk behaviors (e.g., smoking, physical inactivity, obesity) are linked to poor treatment response, side effects, heightened recurrence risk, shortened lifespan, poor quality of life and increased treatment cost for many patients, but treatment of these behaviors is not routinely integrated into cancer care. Utilizing telehealth offers the opportunity to extend patient access to health promotion services that decrease risk behaviors among oncology patients. As developers of evidence-based, technology-assisted risk behavior treatments, we propose to refine and evaluate the first tailored, cancer-specific, telehealth treatment program for multiple risk behaviors to be fully integrated into quality care.

PI_NAMEs: GARCIA, SOFIA F.;HITSMAN, BRIAN L (contact);PHILLIPS, SIOBHAN MARIE;SPRING, BONNIE

PROGRAM_OFFICER_NAME: VANDERPOOL, ROBIN CLINE

PROJECT_TERMS: Address;Adult;arm;Behavior;Behavior assessment;behavior change;Behavior Therapy;Behavioral;cancer care;Cancer Center;Cancer Patient;cancer risk;cancer therapy;care delivery;care providers;Caring;Clinic;Clinical;clinical decision-making;clinical practice;Clinical Services;Code;cost;Custom;dashboard;Data;design;digital data;digital divide;Disease;Equity;evidence base;Fostering;Funding;Goals;Health;health care delivery;health care service utilization;Health Promotion;Health Services Accessibility;Health system;health training;Healthcare;Hospitals;improved;Informal Social Control;Institute of Medicine (U.S.);Intervention;life span;Link;Longevity;Malignant Neoplasms;Medicine;Minority;Obesity;older adult;Oncology;Outcome;Pathway interactions;patient oriented;Patient Outcomes Assessments;patient-clinician communication;Patients;Persons;physical inactivity;Pilot Projects;Policies;pragmatic trial;programs;Provider;provider communication;Quality of Care;Quality of life;Recurrence;Registries;remote assessment;remote delivery;Reporting;Research;Resources;response;Risk;Risk Behaviors;Risk Factors;Risk Reduction;screening;Self Assessment;Services;shared decision making;side effect;Smoking;smoking cessation;social;survivorship;symptom management;Symptoms;System;Techniques;Technology;telehealth;Testing;Time;Tobacco use;tool;Training;treatment as usual;Treatment Cost;treatment program;Treatment Protocols;treatment response;Treatment Side Effects;Universities;Vision;wearable device

PROJECT_TITLE: Scalable TELeheaLth Cancer CARe:  The STELLAR Program to Treat Cancer Risk Behaviors


PI_NAMEs: MEYERHOLZ, DAVID K (contact)

PROJECT_TERMS: Acceleration;Animal Model;Budgets;Cell Culture Techniques;Cells;Consultations;cost;Cryoultramicrotomy;Data;experience;Family suidae;Ferrets;Goals;histotechnology;human model;Human Resources;In Vitro;in vitro Model;in vivo;meetings;Molecular;Pathologist;Pathology;Program Efficiency;programs;Pulmonary Cystic Fibrosis;Reagent;Research Personnel;Resources;Savings;Services;Stains;Technical Expertise;Techniques;Time;tissue fixing;Tissues;Work

PROJECT_TITLE: Pathology Core


NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Gene Therapy;Genetics;Lung;Pediatric;Rare Diseases

PROJECT_TERMS: Address;Adenine;adenovirus mediated delivery;airway epithelium;airway surface liquid;Animal Model;Anions;Bacteria;base editing;base editor;Base Pairing;Bicarbonates;Biogenesis;Biology;Cell Cycle;Cell Differentiation process;Cell division;Cell Line;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;collaborative environment;CRISPR/Cas technology;Cyclic AMP;Cystic Fibrosis;cystic fibrosis airway;Cytidine;Data;Deaminase;Defect;Development;Disease;disease phenotype;disease-causing mutation;DNA;DNA Double Strand Break;early childhood;Epithelial Cells;Epithelium;Event;experimental study;Family suidae;Ferrets;Flow Cytometry;Frequencies;functional restoration;gene repair;gene therapy;gene-editing approach;Genes;Goals;Growth;Guide RNA;Height;High-Throughput Nucleotide Sequencing;homologous recombination;Host Defense;Human;improved;In Vitro;in vivo;Inflammation;innovation;insertion/deletion mutation;Interphase Cell;Knowledge;Laboratories;Life;Lung;Lung Diseases;Measures;Mediating;Mendelian disorder;Methods;Mismatch Repair;Missense Mutation;Mitotic;Modeling;Molecular;Mucins;Mutation;Nonhomologous DNA End Joining;Nonsense Codon;novel;novel strategies;nuclease;Nucleotides;Obstruction;Outcome;Pathogenesis;Patients;Peptides;Persons;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Point Mutation;preference;prevent;Process;programs;Proliferating;protein expression;Proteins;Pulmonary Cystic Fibrosis;Reagent;Regulator Genes;repair strategy;Research;Respiratory Failure;restoration;Ribonucleoproteins;RNA Splicing;Role;Single Nucleotide Polymorphism;single-cell RNA sequencing;Site;small molecule;Somatic Cell;success;Talents;targeted treatment;Technology;Testing;therapeutic evaluation;Time;time interval;tool;Transgenes;Treatment Efficacy;Variant;vector;Viscosity;VX-770;Work

PROJECT_TITLE: Gene Editing Strategies to Correct CFTR Mutations


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Prevention;Social Determinants of Health;Telehealth

PI_NAMEs: GARCIA, SOFIA F. (contact)

PROJECT_TERMS: Acceleration;Behavior Therapy;cancer care;cancer risk;Caring;Clinical;clinical infrastructure;clinical practice;Clinical Trials;Collaborations;Communication;Communities;community advisory board;Development;Education;Equity;Ethics;Evaluation;evidence base;experience;Feedback;Goals;Grant;Health;Healthcare;Healthcare Systems;Hospitals;informatics infrastructure;Infrastructure;insight;Institutional Policy;interdisciplinary collaboration;Lead;Leadership;Maintenance;Methods;Monitor;Newsletter;Oncology;operation;organizational structure;Pilot Projects;Policies;pragmatic trial;preference;Procedures;Process;program dissemination;programs;Publications;Research;Research Methodology;Research Personnel;research study;Resources;Risk Behaviors;synergism;telehealth;timeline;tool;treatment services;Universities;web site;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Pediatric;Rare Diseases

PI_NAMEs: WELSH, MICHAEL J. (contact)

PROJECT_TERMS: aerosolized;airway epithelium;airway remodeling;airway surface liquid;Amphotericin B;Animals;Anions;Anti-Bacterial Agents;antimicrobial;Apical;apical membrane;Bacterial Infections;Bicarbonates;Binding;cell type;Cells;Clinical;Clinical Research;Collaborations;Cyclic AMP;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis airway epithelia;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Defect;Development;Disease;Distal;Environment;Epithelial Cells;Epithelium;Exhibits;Family suidae;Future;Genes;Genotype;Gland;Goals;Height;Heterogeneity;Host Defense;Human;Illinois;Impairment;improved;in vivo;Inflammation;insight;Iowa;Knowledge;Label;Learning;loss of function mutation;Lung;Mediating;Molecular;Mucociliary Clearance;Mucous body substance;mutant;Mutation;Mycoses;Nebulizer;null mutation;Pathogenesis;Persons;Play;programs;Property;Pulmonary Cystic Fibrosis;pulmonary function;Regulation;repaired;Research;Research Personnel;respiratory;Respiratory Failure;restoration;Role;Safety;Staphylococcus aureus;Sterols;Submucosa;success;Surface;Testing;treatment strategy;Viscosity;Work

PROJECT_TITLE: Amphotericin B Restoration of Anion Secretion in Cystic Fibrosis Airways


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Telehealth

PI_NAMEs: PHILLIPS, SIOBHAN MARIE (contact)

PROJECT_TERMS: Address;Applications Grants;Awareness;behavioral health intervention;Behavioral Sciences;Biometry;cancer care;Cancer Patient;cancer risk;Clinical;Clinical Informatics;clinical practice;Collaborations;Common Data Element;Communities;community advisory board;cost effectiveness;culturally appropriate intervention;Data;Data Analyses;Data Analytics;Data Collection;data integration;data management;data quality;Data Sources;data warehouse;Database Management Systems;Databases;design;Development;Devices;digital health;digital repositories;digital tool;Disparity;economic evaluation;Economics;Education;effectiveness research;electronic data;Enrollment;Ensure;Equity;Evaluation;Evaluation Research;evidence base;experience;Funding;Goals;Grant;Health;health assessment;health care service organization;health disparity;Health Promotion;Health Services;Healthcare;implementation research;implementation strategy;improved;Informatics;innovation;Institution;Intervention;Lead;Manuscripts;Measurement;Measures;method development;Methods;Mission;Modification;multimodality;novel;Oncology;Outcome;Patients;Pilot Projects;Policy Analysis;pragmatic study;pragmatic trial;Procedures;Productivity;programs;protocol development;Provider;Publications;Quality Control;recruit;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Support;Resources;Risk Behaviors;Safety;Service delivery model;Services;social media;Spanish;Statistical Data Interpretation;symposium;Technology;telehealth;Testing;tool;Translating;wearable sensor technology;web based interface;web site;webinar;Work;working group

PROJECT_TITLE: Research and Methods Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Eczema / Atopic Dermatitis;Infectious Diseases;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Staphylococcus aureus is a leading cause of human skin infections and is associated with itchy skin lesions in patients with Atopic dermatitis and Impetigo. Here, we investigate the role of S. aureus and its secreted proteases in driving itch during infection, and the role of neurons in mediating skin immune responses. Our study could reveal novel mechanisms of itch and inflammation.

PI_NAMEs: CHIU, ISAAC MING-CHENG (contact);HORSWILL, ALEXANDER R

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Ablation;Afferent Neurons;Affinity;antagonist;Atopic Dermatitis;Automobile Driving;Behavior;Binding;Biochemical;Biological;Biological Assay;Calcium;Cells;Cheek structure;chronic itch;cytokine;Data;Detection;Disease;Enzyme-Linked Immunosorbent Assay;Esthesia;extracellular;Family;G-Protein-Coupled Receptors;Genetic;genetic approach;glutamyl endopeptidase;Goals;host-microbe interactions;Human;Image;Immune;Immune response;Immunologics;immunoregulation;Impetigo;Induced Neurons;Infection;Infectious Skin Diseases;Inflammation;Inflammation Mediators;intradermal injection;knock-down;Lesion;Link;luminescence;Measures;Mediating;Mediator;Microbe;microbial;Modeling;Molecular;Molecular Target;Mus;mutant;Nerve;Nervous System;neural;neurobehavioral;Neurobiology;Neuroimmune;Neurons;neurotransmission;neutrophil;novel;Pain;pain behavior;PAR-1 Receptor;Pathogenesis;pathogenic bacteria;Pathology;Patients;Peptide Hydrolases;pharmacologic;Play;Production;proteinase In;Proteinase-Activated Receptors;Proteomics;Pruritus;receptor;Recombinants;response;Role;Serine Protease;Signal Transduction;Site;skills;Skin;skin barrier;skin damage;skin disorder;skin lesion;Small Interfering RNA;Spinal Ganglia;Staphylococcus aureus;Staphylococcus aureus infection;subcutaneous;Symptoms;Therapeutic;Touch sensation;TRPV1 gene;Virulence Factors;Work

PROJECT_TITLE: Staphylococcus aureus induced itch and neuro-immune signaling in skin infections

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


PI_NAMEs: ENGELHARDT, JOHN F (contact)

PROJECT_TERMS: absorption;Address;Adopted;airway epithelium;Airway Fibrosis;airway surface liquid;Amphotericin B;Anions;Anti-Bacterial Agents;Area;Bicarbonates;Cell Physiology;cell type;Cells;Cellular biology;cellular targeting;Chlorides;Compensation;Complement;Cystic Fibrosis;cystic fibrosis airway;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Defect;defined contribution;detection limit;Development;Disease;disease phenotype;Disease Progression;Duct (organ) structure;Ectopic Expression;Epithelial Cells;epithelial Na+ channel;Ferrets;gain of function;gene complementation;gene replacement;gene therapy;gene-targeted therapy;Genetic;genetic approach;Genetic Engineering;Gland;Goals;Half-Life;Human;In Vitro;in vivo;Inflammation;Ion Channel;Knowledge;Laboratories;Liquid substance;loss of function;Lung;Mediating;Messenger RNA;Modeling;Molecular;Movement;Mucociliary Clearance;Mus;Natural Immunity;NON Mouse;overexpression;Pathogenesis;Phenotype;porcine model;prevent;Process;Property;Pulmonary Cystic Fibrosis;pulmonary function;Regulation;Reporter;Research;restoration;single-cell RNA sequencing;Submucosa;Surface;synergism;Technology;Testing;Transgenic Organisms

PROJECT_TITLE: Conducting Airway Cellular Targets Required for Complementation of CF Lung Disease


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Social Determinants of Health;Telehealth

PI_NAMEs: HITSMAN, BRIAN L (contact)

PROJECT_TERMS: Administrator;Adopted;Budgets;cancer care;Cancer Center;Cancer Patient;cancer risk;Cancer Survivor;cancer therapy;care delivery;Caring;Clinic;Clinical;clinical infrastructure;Clinical Oncology;clinical practice;Collaborations;Communication;Data;Data Collection;data warehouse;Decision Making;digital divide;Electronic Health Record;electronic health record system;Electronics;Enrollment;Ensure;evidence base;Health;health disparity;Health Promotion;Health Services Accessibility;Healthcare promotion;Hospitals;Human;implementation facilitation;Individual;Infrastructure;Institutional Review Boards;Intervention;Knowledge;Malignant Neoplasms;Medicine;Monitor;Nature;Nurses;obesity treatment;Oncology;operation;Outcome;patient health information;patient portal;patient-clinician communication;Patients;physical inactivity;Pilot Projects;Policies;population based;Pragmatic clinical trial;pragmatic trial;preference;programs;Provider;Quality of Care;Randomized, Controlled Trials;repository;Research;Research Methodology;Research Project Grants;Research Support;Risk Behaviors;Safety;Services;Site;System;Technology;telehealth;Tobacco use;Tobacco Use Cessation;tool;Translating;Translations;Treatment outcome;trial design;wearable device;Work;working group

PROJECT_TITLE: Clinical Practice Network


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Nanotechnology;Precision Medicine;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Narrative Triple negative breast cancer (TNBC) is characterized by a distinct, highly heterogeneous molecular profile, aggressive nature, early relapses, the worst survival rates in all breast cancer subtypes and a lack of FDA- approved targeted therapies. Because TNBC cell growth is not dependent on estrogen and progesterone hormones, and epidermal growth factor 2 (HER2/Neu) signaling, the patients cannot benefit from anti-estrogen (i.e., tamoxifen) or anti-HER2 therapies, representing an unmet therapeutic challenge. We recently identified EF2-kinase (EF2K), an unusual member of alpha kinase family and does not have any homology with known kinases, as a prognostic marker for its dramatic association with patient survival and validated it as a potential molecular target in TNBC; thus here we are proposing to develop highly effective, safe and effective therapeutic strategies for targeting EF2K and evaluate their in vivo efficacy as monotherapy and in combination with the standard chemotherapy in clinically relevant preclinical models of TNBC with the long-term goal of translating into the clinic.

PI_NAMEs: OZPOLAT, BULENT  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: advanced disease;Animal Model;aptamer;Binding;Biological Assay;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;c-myc Genes;calmodulin-dependent protein kinase III;Cancer Cell Growth;cancer subtypes;CCL2 gene;Cell Proliferation;Cells;Chemicals;chemotherapy;Clinic;Clinical Trials;clinically relevant;clinically significant;Collaborations;Computer Models;Cyclin D1;Databases;Death Rate;design;Development;Docking;Dose;Drug Kinetics;Drug or chemical Tissue Distribution;EEF2 gene;effective therapy;Epidermal Growth Factor;ERBB2 gene;Estrogen Antagonists;Estrogens;Evaluation;Family;FDA approved;Foundations;FOXM1 gene;Future;Generations;Genes;Genetic;Goals;Half-Life;Heterogeneity;Homology Modeling;Hormones;Hydrophobicity;improved;in silico;In Vitro;in vivo;inhibitor;Invaded;kinase inhibitor;Kinetics;Knockout Mice;Lead;lipid nanoparticle;lung metastatic;Malignant Breast Neoplasm;Mammary Neoplasms;Medicine;member;Methods;Modeling;Molecular;Molecular Profiling;Molecular Target;mortality;Mus;Mutate;nanomolar;nanoparticle delivery;Nature;Neoplasm Metastasis;new therapeutic target;novel;Oncogenic;overexpression;patient derived xenograft model;Patients;Pharmacodynamics;pharmacologic;Phenotype;Phosphotransferases;PIK3CG gene;potential biomarker;pre-clinical;Pre-Clinical Model;preclinical evaluation;preclinical safety;preclinical study;prevent;Primary Neoplasm;Progesterone;Prognosis;Prognostic Marker;Protein Kinase;PTK2 gene;receptor;Relapse;Research Personnel;Resistance;response;RNA Interference;Schedule;screening;Signal Pathway;Signal Transduction;Small Interfering RNA;small molecule;small molecule inhibitor;Structure;Subgroup;Survival Rate;System;Tamoxifen;targeted delivery;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;therapeutically effective;Toxic effect;TP53 gene;transcription factor;Translating;Translations;Treatment Efficacy;Treatment Failure;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Tumor Suppression;Tumor-associated macrophages;tumorigenesis;Vascular Endothelial Growth Factors

PROJECT_TITLE: Novel Targeted Therapeutics for Breast Cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Obesity;Patient Safety;Physical Activity;Prevention;Social Determinants of Health;Telehealth;Tobacco;Tobacco Smoke and Health

PI_NAMEs: SPRING, BONNIE  (contact)

PROJECT_TERMS: Address;Adult;adverse outcome;aged;arm;Attenuated;Behavior;Behavior assessment;Behavior Therapy;Blinded;Body mass index;brief screening;cancer care;cancer clinical trial;Cancer Hospital;Cancer Patient;cancer recurrence;cancer risk;Cancer Survivor;cancer therapy;care systems;Characteristics;Clinic;Clinic Visits;Clinical;clinical center;clinical practice;Clinical Services;comorbidity;cost;COVID-19 pandemic;dashboard;Disease;efficacious intervention;Electronic Health Record;electronic health record system;Electronic Mail;Ethnic Origin;evidence base;Funding;Goals;Guidelines;Health;health care service utilization;health communication;Health Promotion;Health Services;Health Services Accessibility;Healthcare;Healthcare Systems;healthy lifestyle;Hospitals;improved;Individual;Intervention;Longevity;Malignant Neoplasms;Medical;Medicine;Monitor;mortality;novel;Obesity;obesity treatment;Oncologist;Oncology;Outcome;Outcome Assessment;Pamphlets;Participant;Pathway interactions;Patient Care;Patient Outcomes Assessments;patient population;Patient Preferences;patient-clinician communication;Patients;Persons;Physical activity;physical inactivity;Positioning Attribute;Pragmatic clinical trial;pragmatic study;pragmatic trial;Process;programs;Provider;psychosocial;Quality of Care;Quality of life;Race;Randomized;Readiness;Recording of previous events;Recurrence;Reporting;Research;Resources;Risk;Risk Behaviors;Risk Factors;Risk Reduction;Schedule;screening program;Second Primary Cancers;Services;side effect;Site;Smoking;smoking cessation;Socioeconomic Status;Spanish;success;Support System;Survivors;Symptoms;System;telehealth;Time;Tobacco use;Tobacco Use Cessation;Transportation;treatment arm;treatment as usual;Treatment Cost;treatment program;treatment response;trial comparing;United States Agency for Healthcare Research and Quality

PROJECT_TITLE: Pragmatic Trial


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetic Testing;Genetics;Human Genome;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  Over 80% of people with Parkinson's disease (PD) will develop dementia, causing lower quality of life, increased caregiver burden, and worse health outcomes. Although the pathological mechanisms of dementia in PD are poorly understood, Alzheimer's disease (AD) co-pathology is believed to play an important role. Identifying the impact of AD genetic risk factors in PD dementia (PDD) will broaden our understanding of PDD and open the door to developing therapeutic or preventative approaches targeting AD pathology to reduce the burden of dementia in PD patients.

PI_NAMEs: TROPEA, THOMAS FRANCIS (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Affect;Aging;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-42;Autopsy;Award;axonal degeneration;Basic Science;Bioinformatics;Biological;Biological Markers;Biometry;Brain;Brain Diseases;care providers;career;Caregiver Burden;Cerebrum;Clinical;Clinical dementia rating scale;clinical predictors;Clinical Research;Clinical Trials;Cognition;cognitive impairment in Parkinson's;cognitive performance;cohort;Complex;Data;Data Set;Databases;Dementia;dementia burden;dementia risk;Deposition;Deterioration;Disease;disorder control;Early identification;Faculty;Fellowship;Five-Year Plans;Funding;Future;General Population;Genetic;genetic association;Genetic Carriers;Genetic Markers;Genetic Risk;genetic risk factor;Genetic study;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic locus;Goals;high risk;high risk population;Impaired cognition;improved;Inclusion Bodies;Individual;insight;International;K-Series Research Career Programs;Light;Longitudinal cohort;Medical Care Costs;Memory;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Molecular;molecular marker;molecular pathology;Movement Disorders;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Neurobiology;Neurofibrillary Tangles;neurofilament;Neurology;neuron loss;Neuronal Dysfunction;neuropathology;Neurosciences;non-demented;novel;Outcome;Pacific Northwest;Parkinson Disease;Parkinson's Dementia;Pathologic;Pathology;Pathway interactions;Patients;Pennsylvania;Persons;Phenotype;Play;polygenic risk score;poor health outcome;Population;predictive modeling;Predictive Value;Prevalence;Productivity;professor;progression marker;Proteins;Quality of life;Recording of previous events;Research;Risk;risk prediction;risk variant;Role;Scientist;self-directed learning;Severities;skill acquisition;skills;Sum;tau Proteins;tau-1;Testing;Therapeutic;therapy development;Training;Translating;Translational Research;Universities;Variant;Work

PROJECT_TITLE: The Role of Alzheimer's Disease Genetic Risk in Predicting Parkinson's Disease Dementia

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Diabetes;Dietary Supplements;Eye Disease and Disorders of Vision;Neurosciences;Nutrition;Prevention;Sleep Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE This project will enhance the understanding of the role of intrinsically photosensitive retinal ganglion cells function on sleep and circadian regulation in people with diabetes, especially those with retinopathy. It will provide the evidence of potential benefit of melatonin in improving sleep and circadian regulation in patients with type 2 diabetes and diabetic retinopathy, which could lead to improve glycemic control and thus reduce complications associated with this devastating disease.

PI_NAMEs: REUTRAKUL, SIRIMON  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: 6-sulfatoxymelatonin;Acceleration;actigraphy;Adult;Adverse effects;Affect;biomarker validation;Blindness;blood glucose regulation;Blood specimen;Cell Physiology;circadian;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;circadian regulation;Clinical;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Darkness;Data;Diabetes Mellitus;Diabetic Retinopathy;Diet;Disease;Disease Outcome;Disease Progression;DR1 gene;Electroencephalography;Epidemic;Etiology;Exercise;fasting glucose;Foundations;Functional disorder;Future;Glucose;glucose metabolism;glycemic control;Goals;Health;Home;Hormones;Hour;Human;Hydrocortisone;improved;improvement on sleep;Individual;Interruption;Intervention;Knowledge;Light;Link;Measures;melanopsin;Melatonin;melatonin supplementation;Metabolic;Metabolic Control;Monitor;Neural Retina;Neurohormones;Neuronal Dysfunction;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Outcome Measure;Participant;Patients;Persons;Pharmaceutical Preparations;Phase;Physiology;Pilot Projects;Placebos;Polysomnography;Preventive treatment;primary outcome;Randomized;Randomized, Controlled Trials;response;Retinal Diseases;Retinal Ganglion Cells;Role;Salivary;Sampling;Serum;Severities;Signal Transduction;Sleep;Sleep disturbances;sleep pattern;sleep regulation;standard measure;System;Testing;Therapeutic Intervention;treatment strategy;United States;urinary;Urine;vascular abnormality;Work;Wrist

PROJECT_TITLE: Sleep and Circadian Regulation in Diabetic Retinopathy: The Role of Intrinsically Photosensitive Retinal Ganglion Cells and Melatonin Supplementation

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: Boulder

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRATIVE PARP1 is a validated target for cancer therapy in DNA repair-compromised tumors, with four clinically approved drugs and many ongoing phase III clinical trials. We propose to study the structure, activity, inhibition, and downstream effects of PARP1 bound to chromatin DNA. Our quantitative, structural, and mechanistic approaches will aid in the development of the next generation of PARP inhibitors.

PI_NAMEs: LUGER, KAROLIN  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Active Sites;Address;Antineoplastic Agents;Architecture;assay development;Binding;Biochemical;Biological Assay;biophysical properties;brca gene;cancer cell;Cancer Patient;cancer therapy;Cardiovascular Diseases;Catalytic Domain;Cell Death;Cell Line;Cells;chemotherapy;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Clinic;Clinical;clinical application;Complex;crosslink;Cryoelectron Microscopy;Defect;design;Development;DNA;DNA Binding;DNA Damage;DNA Repair;DNA Repair Pathway;dosage;drug efficacy;Drug Targeting;Effectiveness;Environment;Enzymes;experimental study;Glutamates;Goals;Histones;improved;inhibitor;innovation;insight;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Molecular;Molecular Chaperones;Molecular Conformation;Nervous System Disorder;neurotensin mimic 1;next generation;Nuclear;Nuclear Proteins;Nucleosomes;particle;patient population;Patients;Pharmaceutical Preparations;Phase III Clinical Trials;Poly(ADP-ribose) Polymerase Inhibitor;polymerization;Polymers;prevent;Process;Property;Proteins;Radiation therapy;recruit;Relaxation;repaired;Research;Resistance;resistance mechanism;response;Ribose;Role;Serine;Shapes;Signal Transduction;stoichiometry;structural biology;Structure;Substrate Specificity;success;targeted cancer therapy;Therapeutic;tumor;Variant;Zinc Fingers

PROJECT_TITLE: Structure and Mechanism of Chromatin-Bound PARP1

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Dietary Supplements;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Environmental pollutants as well as plant, microbial and host-derived products can bind to aryl hydrocarbon receptors (AhR). Our studies will determine how dietary indoles bind to AhR and then elements in the DNA to produce anti-microbial peptides. These peptides can cause changes in gut microbiota and immunosuppression.

PI_NAMEs: NAGARKATTI, MITZI ;NAGARKATTI, PRAKASH S (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: 3-Dimensional;Affect;antagonist;Anti-Inflammatory Agents;anti-microbial peptide;Antiinflammatory Effect;ARNT gene;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;ATAC-seq;Attenuated;beta-Defensins;Binding;Biological Assay;Broccoli - dietary;Cabbage - dietary;Cauliflower;CD4 Positive T Lymphocytes;Cells;Chromatin;chromatin remodeling;Chronic;Clinical;Colitis;Colon;Colonic inflammation;comparison control;Complex;Crohn's disease;Data;Defensins;dextran sulfate sodium induced colitis;Dietary Factors;Dietary Indole;Dietary Phytochemical;Dioxins;Disease;disease model;DNA;DNA Methylation;Electrophoretic Mobility Shift Assay;Elements;Environmental Pollutants;Environmental Risk Factor;Epigenetic Process;epigenetic regulation;Epithelial Cells;Epithelium;FOXP3 gene;Gastrointestinal tract structure;Gene Expression;Genes;Genetic;gut dysbiosis;gut microbiota;Histone Acetylation;Histone Deacetylase Inhibitor;Histone Deacetylation;histone modification;Human;IL17 gene;Immune response;Immune system;Immunomodulators;immunoregulation;Immunosuppression;Indole-3-Carbinol;Inflammation;Inflammatory Bowel Diseases;intestinal barrier;intestinal epithelium;Intestines;Knockout Mice;Ligands;Ligation;Mediating;microbial;microbial colonization;microbial products;microbiota;MicroRNAs;Modeling;murine colitis;Mus;novel;Pathogenesis;Pathway interactions;Patients;Peptides;Persons;Plants;Play;pollutant;prevent;Prevention;promoter;Property;Protein Family;Quantitative Reverse Transcriptase PCR;Receptor Activation;Regulation;Regulatory T-Lymphocyte;Reporter;Resistance;Response Elements;Role;sensor;Surface;T cell differentiation;T-Lymphocyte;Testing;Tissues;transcription factor;trinitrobenzene sulfonic acid induced colitis;Ulcerative Colitis;villin

PROJECT_TITLE: Role of the environmental sensor, AhR on colitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(04)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE  Suppressive immune cells in tumors are supported by high levels of the amino acid glutamine, and we have recently shown that small molecule glutamine metabolism inhibitors have potent anticancer effectiveness. Mycobacterium tuberculosis, the causative agent of TB, has long been known to release an enzyme that generates high levels of glutamine, and we recently found that the same glutamine metabolism inhibitors that are active in cancer models also act to reduce TB burden, reduce suppressive immune cells, and prolong survival in animal models. This application will further define the immunosuppressive roles of glutamine in the TB granuloma and also investigate a panel of new glutamine metabolism inhibitors as TB therapeutics.

PI_NAMEs: BISHAI, WILLIAM RAMSES (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: 4T1;Adoptive Transfer;Amino Acids;analog;Animal Model;Anti-Bacterial Agents;anti-cancer;anticancer activity;Antigens;antimicrobial;Antineoplastic Agents;Antitubercular Agents;Bacille Calmette-Guerin vaccination;bactericide;Biological Availability;Cancer Model;causal variant;CCAAT-Enhancer-Binding Protein-beta;CD8-Positive T-Lymphocytes;Cells;Clinical;Clinical Trials;Collaborations;Effectiveness;effectiveness evaluation;effector T cell;Enzymes;Flow Cytometry;Fostering;Genetic;Glutamate-Ammonia Ligase;Glutamine;Granulocyte Colony-Stimulating Factor;Granuloma;Growth;HIV;HIV/TB;Human;Immune;immune function;Immunity;Immunotherapeutic agent;improved;In Vitro;Inflammatory;inhibitor;Lipids;Lung;Lymphoid Cell;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Metabolism;metabolomics;Methionine Sulfoximine;Mus;mutant;Mycobacterium tuberculosis;Myeloid Cells;Myeloid-derived suppressor cells;novel;Organ;pathogen;Pharmaceutical Preparations;Population;Prodrugs;Production;Proteins;Purines;Pyrimidine;Resistance;Role;Safety;Seminal;single-cell RNA sequencing;small molecule;Sorting;Structure-Activity Relationship;Suppressor-Effector T-Lymphocytes;T-Cell Activation;Testing;Therapeutic;Tissues;Toxic effect;Treatment Efficacy;Tryptophan;Tryptophan 2,3 Dioxygenase;Tuberculosis;tuberculosis drugs;tuberculosis granuloma;tuberculosis treatment;tumor;tumor microenvironment;tumor progression;Virulence;Work

PROJECT_TITLE: Glutamine metabolism inhibitors for TB and TB-HIV: dual action as host-directed therapies with antibacterial activity

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Social gaze interactions serve a dominant function in contingent and dynamic social exchanges between individuals. However, the causal brain mechanisms underlying complex inter-individual gaze behaviors remain elusive. In this proposal, we will investigate functionally informed causal contributions of the orbitofrontal cortex, the basolateral amygdala, and the communication between the two brain areas, in real-life face-to-face social gaze interactions.

PI_NAMEs: CHANG, STEVE W. C. (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Agonist;Amygdaloid structure;Area;Attention;Behavior;Behavioral;Brain;Brain region;Code;Communication;Complex;Cues;Data;directed attention;Eye;Familiarity;gaze;Human;Individual;information processing;Juice;Lead;Life;Link;Macaca;Modeling;neural;neural circuit;neural correlate;Neurons;neurotransmission;nonhuman primate;Pattern;Personal Communication;preference;Process;receptor;Rewards;Role;Shapes;Signal Transduction;social;Social Behavior;social cognition;social deficits;Social Environment;Social Interaction;Stimulus;stimulus processing;Sum;Testing

PROJECT_TITLE: Prefrontal and Amygdalar Mechanisms of Live Social Gaze Interaction

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Mutations in SYNGAP1 cause a neurodevelopmental disorder, which is associated with intellectual disability, autism spectrum disorder, and motor impairments. This research will use mouse models to investigate how mutations in Syngap1 affect communication between brain cells responsible for the selection and learning of appropriate actions. Our findings will advance our understanding of the cellular and circuit basis of SYNGAP1 disorders and can be leveraged to improve therapeutic possibilities for patients with this and related diseases.

PI_NAMEs: BATEUP, HELEN S. (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: 3-Dimensional;Acute;Adult;Affect;AMPA Receptors;autism spectrum disorder;Behavior;Behavior Control;Behavioral;behavioral phenotyping;Brain;brain cell;cell type;Cellular Morphology;Communication;conditional knockout;Corpus striatum structure;CRISPR-mediated transcriptional activation;critical period;de novo mutation;Dendritic Spines;density;Development;Developmental Delay Disorders;Disease;Electrophysiology (science);Epilepsy;Excitatory Synapse;Exhibits;experimental study;flexibility;Functional disorder;Genes;Genetic;habit learning;Hippocampus;imaging approach;improved;Intellectual functioning disability;Knockout Mice;Label;Language Delays;Learning;Link;Long-Term Potentiation;Measures;Modeling;Monomeric GTP-Binding Proteins;Morphology;Motor;motor control;motor disorder;motor impairment;Motor Skills;mouse model;Movement;Mus;Mutation;N-Methyl-D-Aspartate Receptors;Neurodevelopmental Disorder;Neurons;optogenetics;Output;Pathway interactions;Patients;Pattern;Phenotype;Physiology;Play;Positioning Attribute;postnatal development;postsynaptic;Problem behavior;Property;Proteins;Receptor Signaling;reconstruction;Regulation;Repression;Research;response;restoration;risk variant;selective expression;Sensory;Signal Transduction;Slice;Stereotyped Behavior;stereotypy;Structure;superresolution microscopy;Symptoms;Synapses;synaptic function;Synaptic Transmission;Syndrome;SYNGAP1;Testing;Thalamic structure;Therapeutic;Therapeutic Intervention;trafficking;transmission process;Vertebral column;Work

PROJECT_TITLE: Investigating Syngap1 as a regulator of striatal synaptic function


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: Narrative A vaccine that will be effective in preventing HIV infection and also control virus replication once the virus has taken hold, will require a dual barrier. The first one at the mucosal portal of entry for the virus to prevent or at least minimize the ability of the virus to create a beachhead and two at the systemic level where generalized immune responses are able to control virus that has succeeded in overcoming the first barrier. Our vaccine strategy targets renewable vaginal epidermal stem cells as a permanent source of antigen production which proliferate and elaborate the vaccine antigen along the phases of the reproductive cycle, providing repeated bouts of vaccine antigen presentation as the cells mature and cycle, leading to induction of humoral and cellular immune responses.

PI_NAMEs: GAUDUIN, MARIE-CLAIRE ELISABETH (contact);VILLINGER, FRANCOIS J

PROGRAM_OFFICER_NAME: BOGGIANO, CESAR AUGUSTO

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Animals;Anti-viral Response;Antibodies;Antigen Presentation;Antigens;Attenuated;Attenuated Vaccines;Biopsy;Cells;chronic infection;clinical efficacy;Clinical Trials;Cross-Priming;Curiosities;Cytomegalovirus;Data;Daughter;Development;Dose;draining lymph node;efficacy study;epidermal stem cell;Epithelial Cells;epithelial stem cell;Epithelium;Female;female reproductive tract;follow-up;Genome;Histologic;HIV;HIV Infections;HIV vaccine;HIV/SIV vaccine;Human;immune clearance;Immune response;Immune system;Immune Targeting;Immunization;Immunologic Stimulation;ImmunoPET;improved;in vivo;Infection;Infection Control;infection risk;involucrin;keratinocyte differentiation;Lentivirus;Lentivirus Vector;lymphoid organ;Macaca;Macaca mulatta;Manuscripts;Measures;Modeling;Modification;Monkeys;Mucosal Immune Responses;mucosal site;Mucous Membrane;mutant;novel vaccines;offspring;pathogen;Pathogenicity;Penetration;Phase;Positron-Emission Tomography;preclinical trial;Preparation;prevent;Production;Proliferating;promoter;Proteins;Rectum;Recurrence;reproductive;Resolution;response;Risk;Safety;Site;SIV;SIV Vaccines;Solid;Source;Stimulus;Stratum Basale;System;T cell response;T-Lymphocyte;Testing;Time;time use;Tissues;Transfection;Translating;Translations;transmission process;Vaccinated;Vaccination;vaccination strategy;Vaccine Antigen;vaccine delivery;vaccine platform;vaccine strategy;Vaccinee;Vaccines;Vagina;vector vaccine;Viral;Viral Antigens;viral transmission;Viral Vector;Virus;Virus Replication;Visualization

PROJECT_TITLE: Durable HIV Vaccine Targeting Mucosal Epithelium

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE The “Prevention of Lower Urinary Tract Symptoms” (PLUS) Research Consortium is a transdisciplinary U.S. scientific network established to expand research beyond the detection and treatment of LUTS to the promotion of bladder health and prevention of LUTS in adolescents and women across the life course. Our overarching hypothesis is that healthy voiding and toileting behaviors contribute to improved bladder health and decreased LUTS for adolescent and adult women. Our transdisciplinary PLUS team at the University of Alabama at Birmingham (UAB) proposes three interrelated pathways related to healthy voiding and toileting behaviors that may impact bladder health and prevention of LUTS: (1) conducting a longitudinal cohort study of women to assess bladder health and LUTS across the life course; (2) increase understanding of risk and protective factors to inform plausible intervention targets for healthy voiding and toileting behaviors; and (3) developing delivery models for future bladder health education programming.

PI_NAMEs: MCGWIN, GERALD  (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Activities of Daily Living;Address;Adolescent;Adolescent Medicine;adolescent woman;Adult women;Affect;Age;Alabama;Area;Behavior;Behavioral Medicine;Biological;Biological Markers;Biometry;Bladder;bladder pain;clinical examination;Clinical Research;cohort;Collaborations;Collection;community based participatory research;community engagement;Data Coordinating Center;deprivation;design;Detection;Development;Education;Environment;environmental stressor;Epidemiology;epidemiology study;Evaluation;Exercise;Foundations;Future;Gait speed;Geographic Information Systems;Geriatrics;Goals;Health;health disparity;Health education;Health Services Research;Home environment;Human Resources;improved;Increased frequency of micturition;indexing;Individual;Inflammation;inflammatory marker;Intervention;Intervention Studies;Knowledge;Life Cycle Stages;Literature;Longitudinal cohort study;Longitudinal Studies;lower urinary tract symptoms;Maps;Measures;Medical Sociology;member;Methodology;mHealth;mHealth self-management;micturition urgency;mobile application;Modeling;neighborhood association;neighborhood disadvantage;Nocturia;novel;Occupational;Pain;Participant;Pathway interactions;Personal Satisfaction;Persons;physical state;Policies;Population Heterogeneity;prevent;Prevention;preventive intervention;programs;protective factors;Psyche structure;Public Health;Qualitative Methods;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;response;Risk;Risk Factors;Role;Sampling;Schools;Science;Severities;social;Social Well-Being;Specimen;Symptoms;teacher;Testing;Time;Travel;Universities;Urethra;Urinary Incontinence;Urinary tract infection;Woman;Women's cohort;Women's study

PROJECT_TITLE: Pathways to Lower Urinary Tract Symptoms Prevention in Adolescent and Adult Women.


ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The goal of this project is to engineer therapeutic immune cells that can clear tumors while minimizing toxicity against healthy tissue.

PI_NAMEs: LIM, WENDELL A (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Affinity;antigen detection;Antigen Targeting;Antigens;B-Lymphocytes;Bioinformatics;Brain;cancer cell;CAR antigen;Cell Death Induction;Cell Physiology;Cells;chimeric antigen receptor T cells;Clinical Trials;Cross Reactions;cross reactivity;design;Discrimination;engineered T cells;Engineering;Epidermal Growth Factor Receptor;Goals;high risk;Immunocompetent;Immunotherapeutic agent;improved;In Vitro;in vitro Assay;in vivo;in vivo evaluation;Lung;Malignant Neoplasms;mesothelin;Modeling;mouse model;Mus;Neuroblastoma;Neurons;Normal tissue morphology;Organ;paracrine;Pediatric Neoplasm;preclinical study;Preclinical Testing;prevent;Production;prototype;Publishing;Safety;Series;Signal Transduction;Solid;Solid Neoplasm;success;synthetic biology;T cell therapy;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Technology;Testing;Time;Tissues;tool;Toxic effect;Transcription Repressor;Treatment-related toxicity;tumor;Tumor Antigens;Tumor Tissue;Work;Xenograft Model

PROJECT_TITLE: Ameliorating off-target toxicities of CAR T cells by engineering NOT gates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative  Normal brain functions arise from the activity of populations of neurons within cortical networks. When normal patterns of activity across neuronal populations go awry, many neurological disorders occur. The pro- posed research investigates the neural basis for visual segmentation, a fundamental perceptual function with well-known impairments in some patients. The study will advance our understanding of representing sensory information in neuronal populations in the cerebral cortex. The insights gained from the proposed research may contribute to a better understanding of neurological disorders such as dyslexia and visual agnosia that involve malfunction of visual segmentation.

PI_NAMEs: HUANG, XIN  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Area;area MT;area V1;Brain;Cerebral cortex;Code;Complex;Cues;Data;Databases;Disparity;dorsal visual stream;Dyslexia;Experimental Designs;Feedback;Funding;Goals;imaging Segmentation;Impairment;Individual;insight;Investigation;Link;Location;Measures;Monkeys;Motion;Nervous System Disorder;neural;Neural Network Simulation;neuromechanism;Neurons;neurophysiology;Noise;novel;Patients;Pattern;Perception;Physiological;Population;Process;Property;receptive field;Research;response;Role;segregation;sensor technology;Sensory;Signal Transduction;Speed;statistics;stereoscopic;Stimulus;Structure;Surface;Systematic Bias;Temporal Lobe;Testing;Vision;Vision Disparity;Visual;Visual Agnosias;Visual Motion;visual stimulus;Visual System;Work

PROJECT_TITLE: Neural Codes Underlying Visual Segmentation

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE iPATH will leverage prior federal and private investments in health care quality research to systematically identify, rigorously test, and disseminate promising care delivery innovations in Federally Qualified Health Centers (FQHCs) across four U.S. regions. Research will (a) identify processes and organizational conditions at FQHCs that promote or impede the effectiveness of type 2 diabetes care; (b) adapt a promising patient- centered medical home practice transformation strategy; and (c) test an innovative implementation approach. iPATH will apply novel multi-method, iterative, practice-relevant research focused on patient-centered, team- based, technology-enabled care to promote customized practice transformation that will address equity challenges in diabetes care and improve care for NIH-designated U.S. health disparity populations.

PI_NAMEs: SINGER, SARA JEAN (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Acceleration;acute care;Address;Adopted;Adult;Affect;American;behavioral economics;California;care delivery;Caring;Case Study;Chronic Care;Clinic;Clinical Data;Cluster randomized trial;COVID-19 pandemic;Data;Data Analyses;Data Collection;Data Reporting;data sharing;diabetes control;Diabetes Mellitus;Effectiveness;Elements;Ensure;Environment;Equity;ethnic minority;Ethnic Origin;Evaluation;experience;Exploration, Preparation, Implementation, and Sustainment;Federally Qualified Health Center;Feedback;flexibility;Geographic Locations;Glycosylated hemoglobin A;Goals;Guidelines;health care quality;health disparity;health disparity populations;health equity;High Prevalence;high risk;Hybrids;implementation determinants;implementation/effectiveness;improved;Inequity;innovation;Interview;Investments;Massachusetts;Medical Economics;Methodology;Methods;minority patient;Modeling;National Committee for Quality Assurance;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;novel strategies;Ohio;organizational readiness;Outcome;pandemic disease;pandemic disruption;Patient Care;patient centered medical home;patient oriented;patient safety;Patients;Pilot Projects;poor health outcome;Population;post-COVID-19;post-pandemic;pre-pandemic;Prevalence;Preventive care;Privatization;Process;Puerto Rico;Quality of Care;Race;racial disparity;racial minority;Recommendation;remote health care;Research;SARS-CoV-2 infection;Science;Shoulder;Social Environment;socioeconomic disparity;socioeconomics;Source;Standardization;Symptoms;team-based care;Technology;Testing;tool;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Universities;Variant

PROJECT_TITLE: Implementing Scalable, PAtient-centered Team-based Care for Adults with Type 2 Diabetes and Health Disparities (iPATH)

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Neurosciences;Sleep Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Humans live in a society that has rigid schedules for work, school, and social activities often requiring them to be active when their biological circadian clock is indicating a need for sleep. Misalignment in the timing of the master circadian clock in the brain, the circadian clocks located throughout the body and the onset of sleep or activity can lead to significant adverse health problems. This proposal will examine the role of neurons and non-neuronal brain cells in regulating biological timing and identify possible targets for the therapeutic intervention of circadian-based disorders.

PI_NAMEs: ALLEN, CHARLES N (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Action Potentials;Animals;Argipressin;Astrocytes;Back;Behavioral;Biological;Brain;brain cell;Cells;circadian;circadian pacemaker;Circadian Rhythms;Communication;Connexin 43;Coupling;Disease;Dorsal;Electrophysiology (science);Feeds;GABA Receptor;GABA transporter;gamma-Aminobutyric Acid;Glutamates;Goals;Health;Human;Hypothalamic structure;imaging modality;Individual;intercellular communication;Knowledge;Location;Maintenance;Mediating;Methods;Molecular;molecular clock;mouse model;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neural network;Neuromodulator;neuronal patterning;Neurons;neurotransmission;Neurotransmitters;Output;Pattern;Periodicity;Phase;Phenotype;Physiological;Play;Population Heterogeneity;presynaptic;Property;receptor;Regulation;Reporter Genes;Research;Role;Schedule;Schools;Signal Pathway;Signal Transduction;Sleep;sleep onset;small molecule;social;Societies;suprachiasmatic nucleus;Synapses;Synaptic Receptors;targeted treatment;Testing;Therapeutic Intervention;Transgenic Mice;transmission process;Variant;Vasoactive Intestinal Peptide;Work

PROJECT_TITLE: Mechanisms of GABAergic Signaling in the Suprachiasmatic Nucleus Network

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: This proposal will employ an innovative ribosome profiling method to comprehensively characterize translation dynamics in mouse preimplantation development at the single cell and single embryo resolution. The proposed research will advance our understanding of fundamental processes that control gene expression in mammalian preimplantation development and may ultimately lead to new insights for mitigating the frequent errors that result in birth defects.

PI_NAMEs: CENIK, CAN  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TITLE: Single cell quantification of translation control in early mouse development

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Principal Investigator/Program Director (Last, first, middle): Bashir, Rashid Project Narrative: Sepsis, a life-threatening syndrome that contributes to millions of deaths annually worldwide, represents a moral and economic burden to the healthcare system. We propose to develop a point-of-care microfluidic biochip for measuring cell- surface and plasma-proteins biomarkers that will be used for contributing with early diagnosis and risk stratification of sepsis. The proposed device could transform the current sepsis diagnosis criteria, which are extremely non-specific, into an accurate screening tool to reduce over-prescription of antibiotics, increase survival rates, decrease lengths of stay, and enable more efficient development of treatment options in the future.

PI_NAMEs: BASHIR, RASHID  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acceleration;Accident and Emergency department;Acquired Immunodeficiency Syndrome;Adult;Affect;American;Antibiotics;Bacteremia;Bacteria;Binding Proteins;biochip;Biological Markers;Blood;Blood Cell Count;Blood Circulation;Blood specimen;C-reactive protein;Cause of Death;Cell Surface Proteins;Cells;Cessation of life;Chemicals;Chlamydial pneumonia;Chlamydophila pneumoniae;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;clinical diagnosis;Clinical Research;Collaborations;Computerized Medical Record;cost;Coulter counter;Data;Death Rate;design;Detection;Devices;Diagnosis;Diagnostic tests;Disease;Drops;Early Diagnosis;early onset sepsis;Economic Burden;electric impedance;Electrolytes;Engineering;Ensure;Exhibits;Fever;Floor;Foundations;Functional disorder;Future;Goals;Healthcare Systems;Heart failure;Heart Rate;Hospital Costs;hospital readmission;Hospitalization;Hospitals;Hour;Hydrogels;Hypotension;Immune response;Immune system;Immunoassay;Immunologic Markers;improved;Infection;innovation;Institutional Review Boards;Interleukin-6;Laboratories;Length of Stay;Life;Magnetism;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Measures;Methods;Microfluidics;Monitor;Morals;mortality;multiplex detection;Myocardial Infarction;nano;neutrophil;Organ;Organ failure;particle;pathogen;Pathogen detection;patient population;Patients;Persons;Plasma Proteins;Pneumonia;point of care;Population;Principal Investigator;procalcitonin;programs;Property;protein biomarkers;Proteins;Reaction Time;Reporting;risk stratification;Sampling;Screening procedure;Sensitivity and Specificity;Sepsis;septic patients;Septic Shock;Severities;Signal Transduction;Solid;Speed;Stratification;Surface;Survival Rate;Syndrome;Techniques;technological innovation;Technology;Testing;therapy development;Time;United States;Variant;White Blood Cell Count procedure;Whole Blood;Work

PROJECT_TITLE: Point-of-Care Microfluidic Biochip for Biomarkers Monitoring for Contributing in Early Sepsis Diagnosis

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE  Phosphoinositides (PIPs) are minor components of the eukaryotic membrane but major regulators of cellular functions. One of the cellular processes regulated by PIPs is autophagy, a process essential for a broad range of cellular functions and tissue development, and dysregulated in many human diseases. The proposed studies based on our recent discoveries will uncover novel mechanisms of PIP regulation of autophagy and potentially reveal new therapeutic targets.

PI_NAMEs: CHEN, JIE  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Aging;Animal Model;Autophagocytosis;Autophagosome;Binding;Biochemical;Biogenesis;Biological Assay;Biophysics;Cell Culture Techniques;Cell membrane;Cell Physiology;Cells;Cellular biology;Collaborations;Complex;Cyclic AMP-Dependent Protein Kinases;Data;detection assay;Development;Disease;Ensure;Family;FRAP1 gene;Grant;Guanine Nucleotide Exchange Factors;Human;human disease;In Vitro;in vivo;inhibitor;Injury;insight;Kinetics;late endosome;Link;Lipids;Lysosomes;Mammalian Cell;Mediating;Membrane;Minor;Modeling;Molecular;molecular dynamics;mouse model;Muscle;muscle regeneration;mutant;Mutation Analysis;N-terminal;Nervous System Disorder;new therapeutic target;novel;novel therapeutic intervention;Outcome;Pathway interactions;PH Domain;Phosphatidylinositols;Phosphorylation;Phosphorylation Site;Physiological;Play;Process;Protein Analysis;Protein Isoforms;Protein Kinase C;Proteins;Regenerative capacity;Regulation;Rho-associated kinase;Role;Signal Transduction;single molecule;Site;Skeletal Muscle;stoichiometry;Tissues;Work

PROJECT_TITLE: Phosphoinositide signaling in autophagy

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Rare Diseases;Urologic Diseases

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative The proposed research is relevant to public health because it will provide analytical tools for a deeper dissection of tumor heterogeneity and a comprehensive reanalysis of the vast amounts of sequencing data from large public databases or research clinics. It will also offer new opportunities to understand the plasticity of tumor cells and its relationship with cancer clinical outcomes.

PI_NAMEs: WANG, WENYI  (contact)

PROGRAM_OFFICER_NAME: CHEN, HUANN-SHENG

PROJECT_TERMS: Aftercare;analytical tool;anaplastic thyroid cancer;Bioinformatics;Biological;Biological Markers;biomarker discovery;cancer cell;cancer genome;cancer genomics;Cancer Patient;Cancer Prognosis;cancer type;cell type;Cells;Clinic;Clinical;Clinical Management;clinical practice;Clinical Treatment;comparison group;Complex;Computer software;crowdsourcing;Data;Data Set;design;Dissection;DNA;DNA Sequence Alteration;Ensure;Environment;Equilibrium;Evolution;exome sequencing;experience;Genes;genetic signature;Genetic Transcription;genome sequencing;genomic variation;Genomics;Heterogeneity;high risk;improved;insight;Investigation;Link;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant neoplasm of thyroid;Malignant Neoplasms;Methodology;Methods;Modeling;Molecular;Mutation;neoplastic cell;novel;Outcome;overtreatment;Papillary thyroid carcinoma;Patients;predictive marker;Prevalence;prostate cancer risk;Prostate Cancer therapy;public database;Public Health;reconstruction;Renal Carcinoma;Research;Research Design;Research Personnel;Risk;Sampling;Side;Single Nucleotide Polymorphism;single-cell RNA sequencing;Site;Software Tools;Statistical Methods;Statistical Models;Testing;Time;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;treatment response;tumor;tumor heterogeneity;usability;user friendly software;user-friendly;Validation;Variant;whole genome

PROJECT_TITLE: Statistical methods for genomic analysis of heterogeneous tumors

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Clinical Research;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Vaccine Related

PHR: Project Narrative Many novel drug treatments are being investigated towards a durable HIV cure, including immunosuppressants targeting immune dysfunction and inflammation associated with HIV infection persistence, as well as broadly neutralizing antibodies (bNAbs) that clear virus and HIV-infected cells. This project will 1) explore how varying exposure to the immunosuppressant, sirolimus, administered with a recombinant varicella zoster virus vaccine, decreases HIV reservoirs and restores immune function, and how patient-specific, genetic, and disease factors may contribute to differences in drug effect, and 2) determine if systemic bNAb levels can predict time to viral rebound after antiretroviral treatment interruption. Overall, this research will help inform dosing in people with HIV and future pharmacological investigations in the HIV cure field.

PI_NAMEs: DEITCHMAN, AMELIA N (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: Acceleration;Address;Adverse event;Age;Agonist;Anti-Retroviral Agents;antiretroviral therapy;Award;career;CD4 Positive T Lymphocytes;Cell Cycle;Cells;Characteristics;Chickenpox;Chronic;chronic infection;Clinical;Clinical Pharmacology;Clinical Research;clinical translation;Clinical Trials;Complex;Data;Development;Disease;Disease remission;DNA;DNA Vaccines;Doctor of Philosophy;Dose;Down-Regulation;drug development;Drug Exposure;Drug Interactions;Drug Kinetics;Exposure to;Fostering;FRAP1 gene;Funding;Future;Genetic;Grant;Hematology;Herpesvirus Type 3;Heterogeneity;HIV;HIV Infections;Immune;immune activation;immune function;Immune response;Immune System Diseases;Immune Targeting;Immunity;Immunologic Markers;Immunologics;Immunology;immunomodulatory therapies;immunoregulation;Immunosuppressive Agents;Immunotherapeutic agent;improved;Individual;Inflammation;Inflammatory;inflammatory marker;inhibitor;Interruption;Investigation;K-Series Research Career Programs;Knowledge;Mentors;Mentorship;Metabolic Marker;Modality;neutralizing antibody;novel;novel therapeutic intervention;novel therapeutics;Outcome;Participant;Pathway interactions;Patients;personalized care;Persons;Pharmaceutical Preparations;Pharmacists;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Pharmacology Study;Phenotype;predicting response;preservation;programs;Proliferating;Race;Recombinants;Regimen;Research;Research Personnel;response;RNA;Safety;Sampling;SDZ RAD;sex;Sirolimus;T-Cell Activation;T-Lymphocyte;Therapeutic;Time;Training;trait;Transplant Recipients;treatment risk;trial design;Up-Regulation;vaccine response;Vaccines;Viral;Viral Markers;viral rebound;virology;Virus;VZV vaccine;Weight;Writing;Zoster Vaccine

PROJECT_TITLE: Clinical Pharmacology Approaches towards Accelerating HIV Cure Initiatives

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: EAST SETAUKET

ORG_NAME: AVANTI BIOSCIENCES, INC.

ORG_STATE: NY

PHR: PROJECT NARRATIVE Accumulation of amyloid plaques and the formation of neurofibrillary tangles are critical events in the pathogenesis of AD. Thus, treatments that reduce both are hypothesized to block and potentially reverse pathogenesis and disease progression. Avanti Biosciences is pioneering the development of potent negative allosteric modulators of DYRK1A, a kinase that phosphorylates tau and whose activity is linked to p-tau mediated synaptic and neuronal dysfunction and death in AD. Furthermore, DYRK1A phosphorylates the APP and enhances its affinity for Beta-Secretase 1 (BACE1) and the γ-secretase complex, increasing overall Aβ levels and plaque deposition2. Thus, DYRK1A inhibitors are potentially helpful in treating both hallmarks of AD, neurofibrillary tangles, and amyloid plaques. In collaboration with NYS Institute for Basic Research, Avanti Biosciences has identified a new series of fluoro catechin derivatives that potently and efficiently inhibit the activity of DYRK1A both in vitro and in vivo. The requested funding will allow the progress of our optimized lead compound, ABI-171, into a long-term AD disease animal model and IND enabling studies to determine the new drug’s efficacy and safety profile.

PI_NAMEs: ARALDI, GIAN LUCA  (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Abeta synthesis;Affect;Affinity;Alzheimer's Disease;Alzheimer's disease model;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animal Disease Models;Animals;Anti-Inflammatory Agents;Astrocytosis;Attenuated;Basic Science;behavior test;beta secretase;beta-site APP cleaving enzyme 1;Biological Availability;Biological Sciences;Brain;Canis familiaris;Cardiovascular system;Catechin;Chemistry;Chronic;Clinic;Clinical Trials;Cognition;Collaborations;commercialization readiness;Corpus striatum structure;Data;density;Deposition;Development;Devices;Disease;Disease Progression;Dose;drug efficacy;Drug Industry;Drug toxicity;efficacy study;Enzymes;Event;Family;Formulation;frontal lobe;Funding;gamma secretase;genotoxicity;Glial Fibrillary Acidic Protein;Gliosis;glycogen synthase kinase 3 beta;good laboratory practice;Grant;gray matter;Hepatocyte;Hepatotoxicity;Hippocampus;Human;hyperphosphorylated tau;IL17 gene;In Vitro;in vivo;Inflammation;inhibitor;interest;Interferon Type II;Interleukin-1 beta;Interleukin-6;Investigational New Drug Application;Lead;lead optimization;Link;manufacture;Measures;Mediating;Mediator;medication safety;member;Memory Loss;Metabolism;Methods;Modeling;Monkeys;morris water maze;Mus;nephrotoxicity;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;neuroinflammation;neuron loss;Neuronal Dysfunction;Neurons;Nose;novel therapeutics;NQO1 gene;nuclear factors of activated T-cells;Oxidases;Pathogenesis;Pathway interactions;Peptide Hydrolases;Peripheral;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Pharmacology and Toxicology;Phosphorylation;Phosphotransferases;Plasma;preclinical development;preclinical study;presenilin-1;prevent;Production;Proline;Property;Protein-Serine-Threonine Kinases;Proteins;proto-oncogene protein pim-1;Quinones;Rattus;respiratory;Rodent;Role;Safety;safety study;safety testing;secretase;Senile Plaques;Series;Serine;side effect;Specificity;STAT3 gene;Symptoms;Synapses;tau aggregation;tau Proteins;tau-1;Testing;Therapeutic Index;Tissues;TNF gene;Toxic effect;Toxicology;Tyrosine;Vascular Endothelial Growth Factors;Western Blotting;Work

PROJECT_TITLE: Development of DYRK1A allosteric modulator for the treatment of Alzheimer's Disease


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Dental, Oral, and Craniofacial Disease;HIV/AIDS;Infectious Diseases;Microbiome

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative The accumulation of dental plaque into stable, long-range biofilms leads to chronic periodontitis due to dysbiosis of oral microbiome. This project investigates the consequences of the aging in non-human primate model of SIV infection and antiretroviral therapy on periodontitis related to oral microbiome alterations. Knowledge gained from the research proposed may help improve the regenerative capacity of the periodontal tissue in PLWH.

PI_NAMEs: DATTA, PRASUN K (contact);EBERSOLE, JEFFREY L;RAPPAPORT, JAY

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: 12 year old;20 year old;Adult;Affect;Age;age effect;age group;aged;Aging;animal old age;Animals;Anti-Retroviral Agents;antiretroviral therapy;Biological;Biological Markers;CD4 Positive T Lymphocytes;Characteristics;Chronic;chronic infection;Clinical;collaborative approach;commensal bacteria;comorbidity;Cross-Sectional Studies;Data;Dental caries;Dental Plaque;Development;Diabetes Mellitus;Disease;Documentation;dysbiosis;Ecology;Enrollment;Environment;Experimental Designs;Health;HIV Infections;HIV-1;host microbiome;Human;Immune;immune function;Immune response;Immune system;Immunity;Immunologics;Impairment;improved;Individual;Infection;Inflammation;Inflammatory;Innate Immune Response;innovation;Institution;Knowledge;Ligature;Literature;longitudinal, prospective study;Macaca mulatta;mature animal;Measures;microbial;Microbial Biofilms;microbiome;microbiome alteration;microbiome composition;microbiota;Modeling;Mouth Diseases;Mucous Membrane;multidisciplinary;nonhuman primate;novel;Oral;Oral cavity;Oral Characters;oral infection;oral microbiome;Outcome;pathogenic bacteria;Periodontal Diseases;Periodontitis;Periodontium;Pharmaceutical Preparations;Population;predicting response;Regenerative capacity;Reporting;Research;Research Activity;response;Salivary;Serum;SIV;synergism;Tissues;Tooth structure;Treatment Efficacy;Variant;Viral;Viremia;young adult

PROJECT_TITLE: Periodontitis as a comorbidity in SIV infection and Antiretroviral Therapy

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE Hereditary Spastic Paraplegia (HSP) comprises a group of rare heritable neurological disorders characterized by progressive lower extremity weakness and spasticity resulting from the gradual degeneration of long axons projecting from corticospinal motor neurons (CSMN). While it is known that the most common form, termed SPG4-HSP, is caused by mutations of SPAST, the gene encoding the microtubule-severing protein spastin, the mechanistic basis for the disease remains unknown. Based on novel mechanistic hypotheses, the proposed work utilizes a wide variety of contemporary techniques (including the development and use of novel reporter mouse models) to evaluate mechanisms linking SPAST mutations to CSMN degeneration.

PI_NAMEs: BAAS, PETER W. (contact);MORFINI, GERARDO ANDRES

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Accounting;Address;Adult;Affect;Alleles;Animals;Applications Grants;Autophagocytosis;autosomal dominant mutation;Axon;axonal degeneration;Back;Behavioral;Brain;casein kinase II;Cell Physiology;Code;Communities;Corticospinal Tracts;Coupled;Curiosities;cytotoxic;Data;Defect;Development;Disease;Down-Regulation;effective therapy;Enzymes;Etiology;Experimental Models;fast axonal transport;forging;gain of function;Gait;Genes;Genetic;Hereditary Spastic Paraplegia;Heritability;Human;in vivo;Individual;innovation;Knowledge;Limb structure;Link;loss of function;Lower Extremity;Mediating;Membrane;Microtubules;Modeling;Molecular Motors;motor neuron degeneration;Motor Neurons;mouse model;Movement;Mus;mutant;Mutation;Nervous System Disorder;Neurodegenerative Disorders;Neurons;novel;Organelles;Pathogenesis;Pathogenicity;Pathologic;Patients;Pattern;Phenotype;prevent;Principal Investigator;Property;Protein Isoforms;Proteins;Reporter;Reporting;selective expression;Spastic Paraparesis;spasticity;spastin;Spinal Cord;Swelling;Symptoms;Techniques;Testing;tool;Toxic effect;transgene expression;Transgenic Mice;Transgenic Organisms;Translations;UCHL1 gene;Work

PROJECT_TITLE: Mechanisms of SPG4 Hereditary Spastic Paraplegia

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Infectious Diseases;Microbiome

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Bacterial infections cause numerous changes to our cells, which underlies the morbidity and mortality from infectious diseases. We will determine how our immune system detects these cellular changes to activate anti- pathogen defenses. These findings will characterize a new mechanism of pathogen detection that will substantially advance the field of innate immunity and have broad implications for the study of immune activation.

PI_NAMEs: PUKKILA-WORLEY, READ  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 20 year old;Bacterial Infections;Biogenesis;Caenorhabditis elegans;Cell membrane;Cells;commensal bacteria;commensal microbes;Communicable Diseases;Complex;Data;Defect;detection platform;enteric infection;Epithelial Cells;Fatty Acids;fluidity;gene synthesis;Genes;Genetic study;Genetic Transcription;Homeostasis;Homologous Gene;Host Defense;Immune;immune activation;Immune signaling;Immune system;Immunity;Infection;Inflammatory;innate immune pathways;innate immune sensing;insight;intestinal epithelium;Intestines;Lead;Length;Lipids;Mammals;MED15;Membrane;Membrane Fluidity;Membrane Lipids;Microbe;microorganism;Molecular;Monitor;Monounsaturated Fatty Acids;Morbidity - disease rate;mortality;mutant;NAD+ Nucleosidase;Natural Immunity;Nematoda;novel;p38 Mitogen Activated Protein Kinase;pathogen;Pathogen detection;pathogenic bacteria;pathogenic microbe;Pathology;Pathway interactions;Pattern Recognition;Pattern recognition receptor;Phenotype;Phospholipids;Physiology;Plants;Plasma Cells;Process;Resistance;response;restoration;Signal Transduction;stem

PROJECT_TITLE: Detection of pathogen infection by monitoring host cell membrane dynamics

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Aging;Genetics;Kidney Disease

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will seek fundamental knowledge regarding the reasons why kidneys age so that these pathways can be potentially modified when superimposed stress is added to an aged kidney such as disease and surgical loss of kidney mass.

PI_NAMEs: SHANKLAND, STUART JAMES (contact);WESSELY, OLIVER

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Acceleration;Address;Age;age acceleration;age related;age related decline;aged;Aging;aging related;autocrine;Cell Aging;cell type;Cells;chemokine;Cicatrix;Coculture Techniques;cytokine;Data;Data Set;Deposition;Devices;Dialysis procedure;Disease;Disease Outcome;Elderly;Epithelial Cells;Exhibits;Experimental Designs;extracellular;Extracellular Matrix Proteins;Face;Feasibility Studies;Feedback;Gene Expression;gene function;Genetic;Glomerular Filtration Rate;glomerular function;glomerulosclerosis;Goals;Grant;Health;healthspan;Human;Hypertrophy;Immune response;Impairment;Individual;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;innovation;Interferons;Interleukins;Kidney;kidney biopsy;Kidney Diseases;Knowledge;Life;Life Expectancy;life span;Ligands;Methodology;Modeling;mouse model;Mus;novel;Nuclear;old mice;older patient;Older Population;Operative Surgical Procedures;Outcome;paracrine;Parietal;pathological aging;Pathway interactions;Patients;PD-1 pathway;Phenotype;Physiology;Play;podocyte;Population;postmitotic;Process;programmed cell death protein 1;Proteins;Public Health;Publishing;receptor;Regulation;Renal function;Renal glomerular disease;Renal Mass;Reporting;Research;response;Role;senescence;senescence associated secretory phenotype;Signal Transduction;Source;Stress;Structure;Surface;Testing;Therapeutic;Thinking;Time;TNF gene;Toll-like receptors;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Mice;translational impact

PROJECT_TITLE: Autocrine and paracrine podocyte signals decrease glomerular function/health in aged kidneys

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-W(05)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Immunization;Infectious Diseases;Microbiome;Pediatric;Prevention;Vaccine Related

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Public Health Relevancy Statement Enteric viral infections, including those caused by rotaviruses (RV), remain a major health scourge resulting in severe distress to millions and hundreds of thousands of deaths annually. Better understanding of why vaccines directed against rotavirus fail where they are most needed is essential to alleviate this public health menace.

PI_NAMEs: GEWIRTZ, ANDREW T (contact);RAMANI, SASIREKHA

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: adaptive immunity;Antibodies;Antibody titer measurement;Antigens;Attenuated;Attenuated Vaccines;Automobile Driving;Bacteria;Bioreactors;candidate identification;Cessation of life;Child;Childhood;cohort;Developing Countries;Development;Disease;Distress;Dose;enteric virus infection;Enterocytes;Epithelial Cells;Epithelium;Exposure to;Failure;fecal transplantation;Feces;gastrointestinal epithelium;Germ-Free;Goals;gut microbiome;gut microbiota;Health;Heterogeneity;Human;human microbiota;Humanities;Immunity;In Vitro;Incidence;Infant;Infection;Interferons;Intestines;Knowledge;Mediating;Microbe;microbial;microbial community;microbiome research;microbiota;microbiota composition;microbiota transplantation;Modeling;mouse model;Mucosal Immune Responses;Mus;novel strategies;Oral;Oral Administration;oral vaccine;Organoids;Outcome;Oxygen;Pediatric cohort;Phenotype;prevent;Prevention;Public Health;Publishing;Research;Resistance;response;Role;Rotavirus;Rotavirus Infections;Rotavirus Vaccines;Scourge;Shapes;stool sample;System;Testing;Transplantation;unpublished works;Vaccination;vaccine efficacy;vaccine failure;Vaccinee;Vaccines;Viral;Viral Vaccines;Virulent;Work

PROJECT_TITLE: Intestinal microbiota-mediated rotavirus vaccine failure

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science

PHR: PROJECT NARRATIVE Economic prosperity and research institution competitiveness demand diversity of the biomedical workforce and diversity in the breadth of scientific inquiry; however, there is a documented shortage of underrepresented minorities (URM) represented in science. Thus, this proposal will establish a new one-year Postbaccalaureate Research Education Proposal at UW-Madison (UW-PREP) that will fill a current gap that exists in the pipeline for increasing the number of URM individuals that are prepared to take on rigorous graduate training in the biomedical sciences. The UW-PREP uses evidence based Entering Research and Mentor Training curricula alongside a vast array of resources and dedicated faculty and staff to prepare extraordinary URM scholars towards impactful and productive careers in the biomedical workforce.

PI_NAMEs: JORGENSEN, JOAN S (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Active Learning;Address;Advisory Committees;Advocacy;Affinity;Agriculture;Amber;Area;Atmosphere;Awareness;Badger;Biological Sciences;Biomedical Research;career;career development;Collection;college;Communication;Communities;Competence;Country;Dedications;design;Development;Development Plans;Doctor of Philosophy;Economics;Education;education research;Educational Activities;Educational Curriculum;Environment;Equity;Ethics;evidence base;expectation;experience;Faculty;faculty mentor;Fostering;Foundations;Funding;Future;Geography;Goals;Growth;Health;Heart;high school;Hobbies;Individual;Infrastructure;innovation;Institution;interest;laboratory experience;Lead;Leadership;Learning;learning strategy;Libraries;life-long learning;Maintenance;matriculation;member;Mental Health Services;Mentors;Mentorship;Minority Groups;Mission;National Institute of General Medical Sciences;Participant;Partner in relationship;peer;peer coaching;physical conditioning;Postbaccalaureate;Postdoctoral Fellow;Productivity;programs;Psyche structure;Publishing;Recreation;recruit;Reproducibility;Research;Research Training;Resources;responsible research conduct;Role;Schedule;Schools;Science;Scientific Inquiry;Scientist;Self Efficacy;Self Perception;Side;skills;social capital;Social Identification;Sports;Students;success;Surveys;symposium;Training;training opportunity;Training Programs;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Veterinary Medicine;Veterinary Schools;Vocational Guidance;Wisconsin;Work;Workplace

PROJECT_TITLE: University of Wisconsin-Madison Postbaccalaureate Research Education Program (PREP) for increasing diversity in STEM

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE/ LAY SUMMARY This proposal represents Mayo Clinic’s application to participate in the HeartShare Research Consortium, a program established by the National Institutes of Health. This team science initiative will be enabled by advances in data science and focus on determining the causes of heart failure (HF) with preserved ejection fraction (HFpEF). The HeartShare initiative will ultimately lead to new ways to diagnose and treat HFpEF.

PI_NAMEs: BORLAUG, BARRY A. (contact);REDFIELD, MARGARET M

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Acceleration;Adipose tissue;Algorithms;aptamer;Artificial Intelligence;Automobile Driving;Belief;Biological;Businesses;Cardiac;Cardiovascular Diseases;circulating biomarkers;Clinic;Clinical;clinical center;Clinical Data;Clinical Investigator;clinical practice;Clinical Research;Clinical Trials;Collaborations;Communities;Complex;complex data;Consensus;Data;Data Collection;Data Science;Data Scientist;Data Set;Dedications;Diagnosis;Disease;effective therapy;EFRAC;Enrollment;Etiology;experience;Functional disorder;Future;Generations;Goals;Heart;Heart failure;hemodynamics;Immersion;Industry;Internships;Intervention Trial;large datasets;Machine Learning;machine learning model;Medical;Methods;Mission;Modeling;Muscle;Myocardial;novel diagnostics;novel marker;novel therapeutic intervention;Organ;Patient Recruitments;patient retention;Patients;Pattern;Phenotype;Physiological;preservation;Process;Productivity;Program Development;programs;Proteins;Proteomics;Protocols documentation;Public Health;Research;Research Personnel;Resources;Science;senescence;Skeletal Muscle;skill acquisition;Specific qualifier value;success;supervised learning;Systemic disease;targeted agent;targeted treatment;Technology;Testing;Therapeutic;Translations;United States National Institutes of Health;unsupervised learning

PROJECT_TITLE: Mayo Clinic HeartShare Clinical Center