ORG_CITY: Columbus

ORG_DEPT: GENETICS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Retroviruses must integrate into their host’s genome to cause a variety of devastating diseases including AIDS (HIV-1) and leukemia (HTLV-1). Integration is catalyzed by a complex between the viral integrase (IN) protein and the viral cDNA (termed an intasome), that for HIV-1 assembles with 12-16 IN subunits. The goal of this proposal is to quantitatively determine the biophysical rules that guide HIV-1 intasome assembly progressions as well as the effect of HIV-1 IN-multimer architecture on host genome integration.

PI_NAMEs: YODER, KRISTINE E (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;animation;antiretroviral therapy;Architecture;Binding;Biology;Biophysics;cellular transduction;Chimera organism;Chromatin;Chromosomes;Clinical;cofactor;Collaborations;combinatorial;Complex;Costs and Benefits;design;dimer;Disease;DNA;DNA Repair;Drug resistance;Drug Targeting;Exhibits;Family member;feature detection;flexibility;Genome;genomic RNA;Genomics;Goals;Histones;HIV;HIV-1;HIV-1 integrase;Human;Human Genome;imaging platform;In Vitro;in vitro activity;Individual;Infection;innovation;Integrase;Integration Host Factors;integration site;Kinetics;Length;Lentivirus;Lesion;leukemia;Link;Long Terminal Repeats;mammary tumor virus;Mechanics;molecular imaging;Mouse Mammary Tumor Virus;Mutation;Nuclear Envelope;Nucleosomes;Outcome;pandemic disease;particle;Pathogenicity;Pattern;Peptides;Positioning Attribute;Post-Translational Protein Processing;Process;Productivity;Proteins;prototype;Regimen;Reporting;resistance mutation;Retroviridae;Reverse Transcription;Role;Side;single molecule;Site;Spumavirus;stoichiometry;Structure;therapeutic target;Time;transcriptional coactivator p75;vector;Viral;Virus

PROJECT_TITLE: HIV-1 Intasome Assembly and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-E(02)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Mental Health;Mental Illness;Prevention;Primary Health Care;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: People with serious mental illness SMI comprise five percent of the US population and experience one of the largest cardiovascular disease-related mortality disparities of any group with rates two times higher, and dying 10-20 years earlier, than the general population. Widespread scale-up of evidence-based interventions to reduce cardiovascular disease risk in the population with serious mental illness is needed to address the significant disparities in lifespan experienced by this group. This proposed study leverages national expertise in cardiovascular risk reduction interventions, implementation science, and community and State policymaking to enhance uptake of evidence-based interventions to prevent cardiovascular disease among persons with serious mental illness, through strong community partnerships that are enhanced using novel implementation science strategies.

PI_NAMEs: DAUMIT, GAIL L. (contact);KILBOURNE, AMY M

PROGRAM_OFFICER_NAME: ILIAS, MALIHA R

PROJECT_TERMS: Address;Adoption;Affordable Care Act;Behavioral;behavioral health;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;care coordination;Caring;Cholesterol;Climate;clinically significant;Communities;Community Health;community partnership;Complementary therapies;Coping Skills;cost;Counseling;Death Rate;disease disparity;Disparity;effective intervention;effectiveness evaluation;effectiveness/implementation trial;efficacious intervention;Evidence based intervention;Evidence based practice;experience;Funding;General Population;Goals;Health;Health behavior change;health equity;health management;Health Promotion;Health system;Home;Impaired cognition;implementation fidelity;implementation intervention;implementation science;implementation strategy;implementation study;Improve Access;improved;Infrastructure;innovation;Intervention;Life;life span;Link;Maryland;Measures;Medicaid;Medical;medical specialties;Mental Health;mental health organization;Michigan;mortality disparity;National Heart, Lung, and Blood Institute;National Institute of Mental Health;novel;Outcome;Participant;Persons;Phase;physical conditioning;Policy Making;Population;population health;Prevalence;prevent;Primary Care;primary care services;primary outcome;Productivity;programs;Proliferating;Provider;provider-level barriers;psychiatric symptom;Qualifying;Quality of Care;Randomized;Replicating Effective Programs;Risk Behaviors;Risk Factors;Risk Reduction;scale up;screening;secondary outcome;Self Efficacy;Sequential Multiple Assignment Randomized Trial;severe mental illness;Site;Testing;Training;trial design;uptake;waiver;Work;working group

PROJECT_TITLE: Achieving Cardiovascular Health Equity in Community Mental Health: Optimizing Implementation Strategies


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Pediatric;Prevention;Suicide;Violence Research;Youth Violence

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE This research is one of the first steps to understanding how and when self-injurious thoughts and behaviors (STBs) emerge in young children during middle childhood. Findings will help identify potential risk factors and mechanisms that may serve as targets for preventing STBs earlier in development before the adolescent period. Findings will set the stage for future research studies aimed at carefully understanding developmental pathways toward STB risk from childhood through adolescence.

PI_NAMEs: MILLER, ADAM BRYANT;OPPENHEIMER, CAROLINE  (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: 7 year old;Adolescence;Adolescent;Adolescent Risk Behavior;Adult;Age;aged;Aggressive behavior;Behavior;behavior measurement;behavior prediction;biological sex;Caregivers;Catchment Area;Cessation of life;Child;Childhood;Clinical;Communities;critical period;Data;Development;diaries;Emotional;Enrollment;Event;experience;Exposure to;Feeling suicidal;Female;follow up assessment;Future;Goals;Grain;Home;Intervention;Interview;life span;Link;Measurement;Mediation;Mental disorders;Methods;middle childhood;Modeling;multimodality;National Institute of Mental Health;non-suicidal self injury;Nursery Schools;Parents;Pathway interactions;peer;Physiological;preadolescence;prevent;Prevention;Process;prospective;psychologic;Psychopathology;Questionnaires;Race;racial difference;racial diversity;Recording of previous events;Recurrence;Research;research study;respiratory;response;Risk;Risk Behaviors;Risk Factors;Sampling;School-Age Population;Self-Injurious Behavior;sex;Sex Differences;Sinus;social;stressor;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide rate;Testing;theories;Thinking;Time;Translation Process;Work;Youth

PROJECT_TITLE: Longitudinal examination of emotional reactivity and reactive aggression linking threat exposure with childhood self-injurious thoughts and behaviors

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Heart Disease;Neurosciences;Patient Safety

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Though cardiac arrest is common, with an estimated 250-350,000 out-of-hospital and 250-750,000 in-hospital events occurring in the U.S. each year, survival rates remain at only 5-20% and many survivors suffer severe brain injury. Developing interventions to reduce brain injuries among survivors of cardiac arrest is essential in order to improve neurological outcomes and patient survival. This planning grant aims to collect information that will help to design a multi-site clinical trial to determine whether the administration of magnesium following an in- hospital cardiac arrest event is feasible and safe and if it improves survival and neurological outcomes.

PI_NAMEs: PARNIA, SAM  (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Adverse event;American Heart Association;Animals;Anoxia;Anoxic Encephalopathy;Apoptosis;Attenuated;Biological Assay;Biological Markers;Blood;Blood flow;Blood Pressure;Brain;Brain Injuries;Cardiopulmonary Resuscitation;Caring;Cell Death;Cessation of life;Circulation;Collection;Critical Care;Data;Data Collection;Dedications;design;Eligibility Determination;Enzymes;Event;excitotoxicity;feasibility testing;Goals;Grant;Heart Arrest;Hospitals;Hour;Human;improved;Incidence;Inflammation;Inflammatory;Informed Consent;Infrastructure;Injury;Institutional Review Boards;International;Intervention;Ischemia;Link;Magnesium;Meta-Analysis;Methods;Mg supplementation;Minocycline;Mitochondria;MK801;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;N-Methyl-D-Aspartate Receptors;Nervous System Physiology;Neurological outcome;Neurological status;neuroprotection;Neuroprotective Agents;NMDA receptor antagonist;Normal saline;novel;Odds Ratio;Outcome;oxidative damage;Oxidative Stress;Pathway interactions;Patients;pharmacologic;Pilot Projects;pilot test;Placebos;prevent;Process;Process Assessment;Process Measure;Randomized;Randomized, Controlled Trials;recruit;Reperfusion Injury;Reperfusion Therapy;Research;Research Design;Research Personnel;Resuscitation;Retrospective Studies;safety and feasibility;sample collection;Sampling;secondary endpoint;Series;Serum;Serum Markers;severe injury;Site;standard of care;Standardization;Stroke;survival outcome;Survival Rate;Survivors;Temperature;Testing;Time;timeline;Traumatic Brain Injury;Ventilator;Work

PROJECT_TITLE: Neuroprotection following cardiac arrest: A Randomized Control Trial of Magnesium

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: This project aims to determine the principles by which neuronal populations communicate with each other across multiple brain areas. The misregulation of inter-areal signaling is thought to be central in psychiatric  disorders like schizophrenia and autism. By understanding how communication is implemented and  modulated, we will be better placed to understand these disorders and develop treatments for them.

PI_NAMEs: KOHN, ADAM ;MACHENS, CHRISTIAN ;YU, BYRON M. (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;analytical tool;Anatomy;Area;area striata;area V1;autism spectrum disorder;Brain;Calcium;Collaborations;Communication;Data;Dimensions;Disease;Electrodes;Feedback;Floods;Functional Magnetic Resonance Imaging;Goals;Image;insight;Macaca;Mental disorders;Methods;neural;Neurons;nonhuman primate;Pathway interactions;Pattern;Population;Poverty;Process;Property;response;retinotopic;Role;Sampling;Schizophrenia;Signal Transduction;Statistical Methods;System;Techniques;Technology;Time;tool;transmission process;Utah;Visual Cortex;Visual System;Work

PROJECT_TITLE: CRCNS: Dissecting Directed Interactions Amongst Multiple Neuronal Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(50)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Skin Cancer

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Narrative  Our proposed studies will not only reveal novel regulatory mechanism of interferon signaling, but also provide important insights into the function of STAG2, an emerging but understudied tumor suppressor, at the crossroad of 3D genome organization and tumor immunity. Importantly, our studies will facilitate future translational research on biomarker discovery for immune checkpoint blockade.

PI_NAMEs: ZHENG, BIN  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: 3-Dimensional;Address;anti-PD-1;anti-PD1 therapy;Binding;Binding Sites;Biology;biomarker discovery;BRAF gene;Cancer Biology;cancer cell;CD8-Positive T-Lymphocytes;Cell Nucleus;ChIP-seq;Chromatin;Chromatin Loop;Chromatin Structure;Clustered Regularly Interspaced Short Palindromic Repeats;cohesin;Compensation;Complex;CSPG6 gene;Enhancers;exhaustion;Future;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genome;Hi-C;Human;Human Genome;immune checkpoint blockade;Immune Evasion;In Vitro;insight;Interferon Type I;Interferons;ISGF3G protein;knock-down;Length;Malignant Neoplasms;malignant phenotype;mammalian genome;Mediating;Melanoma;Melanoma Cell;Modeling;Molecular;Mus;mutant;Mutate;Mutation;novel;paralogous gene;Pathway interactions;programmed cell death ligand 1;promoter;protein complex;Regulation;Resistance;response;Role;Sampling;Signal Pathway;Signal Transduction;small hairpin RNA;Solid Neoplasm;T cell infiltration;T-Lymphocyte;targeted treatment;Testing;transcription factor;transcriptome sequencing;Translational Research;tumor;Tumor Immunity;Tumor Suppressor Proteins

PROJECT_TITLE: Regulation of interferon signaling in melanoma by the cohesin complex protein STAG2 via 3D genome organization

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Microbiome;Neurosciences;Nutrition;Pediatric;Prevention

ORG_CITY: IOWA CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Studies have shown that early life exposures can influence neurodevelopment, and gut microbiome composition and function, however, studies linking early life environmental metal exposure to the gut microbiome in childhood, and their combined associations with neurodevelopment are lacking. The proposed research will investigate these associations and their timing by integrating early life measures of metal exposure, detailed analysis of the gut microbiome and metabolome, and behavioral and biological measurements of neurodevelopment. Filling these knowledge gaps will provide information to better inform future interventions.

PI_NAMEs: EGGERS, SHOSHANNAH IYLENE (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: 11 year old;Address;Adolescence;Age;Area;Attention;behavior measurement;Behavioral;Biological;Biological Markers;Biology;Biometry;Birth;Blood;Brain;career;career development;Chemical Exposure;Chemicals;Childhood;Cities;Clinical;cohort;Collaborations;Copper;Cross-Sectional Studies;Data;Data Analyses;Development;early detection biomarkers;early life exposure;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;Epidemiologist;epidemiology study;executive function;Faculty;Faith;Feces;fetal;Foundations;Funding;Future;Goals;Growth;gut bacteria;gut microbiome;gut-brain axis;Hair;Health;Human;Human Microbiome;Hydrocortisone;Individual;infancy;Infant;innovation;interest;Intervention;Knowledge;Laboratories;Lead;Learning;Life;Link;Manganese;Measurement;Measures;Mediation;meetings;Mentors;Mentorship;Metabolic;metabolome;metabolomics;metagenomic sequencing;Metagenomics;Metal exposure;Metals;Methodology;Mexico;microbial;Microbiology;microbiome;microbiome analysis;microbiome composition;microbiome research;Modeling;multidimensional data;multidisciplinary;multiple omics;National Institute of Environmental Health Sciences;neurobehavioral;neurodevelopment;Neurologic;Neurological outcome;neurotoxicology;novel;Obesity;Observational Study;Pathway interactions;pilot test;Play;Positioning Attribute;Predisposition;prenatal;prenatal exposure;prospective;Proteobacteria;Protocols documentation;Research;Research Activity;research and development;Research Personnel;Research Proposals;Resolution;Role;Rotation;sample collection;Second Pregnancy Trimester;Secure;Shapes;Shotguns;skill acquisition;skills;social stressor;stool sample;success;symposium;tenure track;Time;time use;Tooth structure;Training;Training Activity;Work;Zinc

PROJECT_TITLE: Early life metal exposure, the gut microbiome, and neurodevelopment in childhood

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY HEALTH NETWORK

ORG_STATE: ON

ORG_ZIPCODE: M5G 2C4

PHR: Project Narrative Dysphagia (swallowing impairment) is a serious health condition seen in many age-related disease and injury processes. Although videofluoroscopy (VF) is an international “gold standard” dysphagia diagnostic exam, there is a paucity of available normative physiologic VF reference values in healthy adults across the age span to guide interpretation of these examinations. We propose to extend our prior work on the quantitative measurement of swallowing physiology from VF examinations to establish reference values for swallowing in healthy adults, and to identify clinical decision point values for differentiating healthy swallowing across the age span from disordered swallowing in several high-risk clinical populations to study dysphagia.

PI_NAMEs: PLOWMAN, EMILY KATE;STEELE, CATRIONA MARGARET (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Accounting;Address;Adult;Age;age-related disease;Aging;Agreement;Amyotrophic Lateral Sclerosis;Area;Barium;bench to bedside;Blood Tests;Bolus Infusion;Cardiovascular system;caregiver quality of life;Cholesterol;Chronic Obstructive Pulmonary Disease;Clinical;clinical risk;Clinical Trials;cohort;cost;COVID-19 survivors;Data;Deglutition;Deglutition Disorders;Diabetes Mellitus;Diagnosis;Diagnostic;Diet;Disease;Effectiveness;empowerment;Event;evidence base;Functional disorder;Goals;Health;healthy aging;Height;high risk;Impairment;improved;indexing;individualized medicine;Injury;Intensive Care;International;Intervention;kinematics;Knowledge;life span;Measurement;Measures;Mechanical ventilation;Medicine;Methods;Monitor;Morbidity - disease rate;Nature;older adult;Operative Surgical Procedures;Outcome Measure;Parkinson Disease;Participant;Patient Education;patient population;Patient-Focused Outcomes;Patients;Pediatrics;Physiological;Physiology;Population;Process;prospective;Protocols documentation;Publications;Publishing;Reference Values;Research;Resources;Sample Size;Sampling;scale up;Severities;Severity of illness;sex;Stroke;Testing;Texture;Therapeutic;Tongue;Translations;treatment planning;United States;uptake;Variant;Vision;Weight;Work

PROJECT_TITLE: Establishing Reference Values and Clinical Decision Points for Quantitative Videofluoroscopic Measures of Swallowing

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Palliative Care;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE In the context of shrinking family size and growing complexity and diversity of family and household structures, characterizing the full scope of informal caregiving, such as who provides caregiving to the person with dementia, what caregiving roles are played by the multiple members of these networks, and how the various members are socially connected, will be required to inform responsive public health approaches and policies to support the growing community of caregivers, and to improve healthcare and social services for persons with dementia. The proposed work is to develop CareNet, a digital caregiving network assessment tool, that will be easily deployed by providers and researchers to fully characterize the caregiving network of a person with dementia.

PI_NAMEs: DE VITO DABBS, ANNETTE J;SONG, MI-KYUNG  (contact)

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: Affect;Alzheimer's disease related dementia;Assessment tool;Behavior;Black race;care systems;Caregiver well-being;Caregivers;caregiving;caregiving research;Caring;Characteristics;cohesion;Communication;Communities;Complex;Computer software;Data;Data Analyses;Data Collection;Decision Making;Dementia;Dementia caregivers;dementia caregiving;design;digital;digital tool;Evaluation;Family member;Family Sizes;field study;Financial Hardship;Friends;Future;Health;health care service;Health Services;Home;Hospitalization;Household and Family;improved;in-home care;Individual;informal caregiver;informal caregiving;informant;Intervention;Interview;iterative design;Knowledge;learning outcome;Literature;Long-Term Care;Maps;member;Methods;Monitor;multiple chronic conditions;older adult;Outcome;Participant;Pathway Analysis;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;physical conditioning;pilot test;Play;Policies;practical application;practice setting;preference;primary caregiver;Process;Property;prototype;Provider;psychosocial;Public Health;Research;Research Personnel;response;Risk;Role;Sampling;Self Management;Series;social;Social Environment;Social Network;social service provider;social structure;Social Work;Software Tools;Structure;Subgroup;Summary Reports;Surveys;Telephone;Testing;tool;Training;usability;user centered design;Vertebral column;Visualization;Work

PROJECT_TITLE: CareNet, An Interactive Digital Tool to Assess Informal Caregiving Networks of Older Adults with Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-A(56)R]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PUBLIC HEALTH RELEVANCE  Trauma and shock activate pathways of inflammation that can lead to organ failure and death. The mechanisms of activation of inflammation in different organs and cell-types is not well understood, but knowing how cell, tissues and organs respond to shock may improve our future ability to prevent and treat organ failure in trauma patients. Our research investigates effects of activation of an inflammatory protein, caspase-11, on organ damage and inflammation during shock, and investigates inhibition of caspase-4/11 as a treatment approach to prevent organ failure in severely injured patients.

PI_NAMEs: SCOTT, MELANIE J. (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Binding;Biochemical;Biochemical Markers;Bleeding time procedure;Blood Coagulation Disorders;Blood flow;Blood Platelets;Cardiolipins;Caspase;CD14 Antigen;Cell Death;cell injury;Cell Line;cell type;Cells;Cessation of life;Coagulation Process;cytochrome c;cytotoxicity;Data;Deposition;Diffuse;Dose;Effectiveness;effectiveness evaluation;Endothelial Cells;extracellular vesicles;Fibrin;Future;Goals;Grant;Hemorrhage;Hemorrhagic Shock;Hepatocyte;Histologic;HMGB1 gene;Human;Image;improved;In Vitro;in vivo;Infection;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Inflammatory Response;inhibitor;Injury;intravital imaging;Knockout Mice;Leukocytes;Liver;Mediating;Microfluidics;Mitochondria;Modeling;mouse model;Multiple Organ Failure;Multiple Trauma;Mus;neutrophil;novel;novel therapeutics;Organ;Organ failure;organ injury;Pathway interactions;Patient-Focused Outcomes;Patients;Physiological;Platelet Activation;Platelet aggregation;prevent;Proteins;public health relevance;Research;Resuscitation;Role;Safety;Sampling;Sepsis;severe injury;Shock;Stress;Supportive care;System;systemic inflammatory response;therapeutic target;Thromboplastin;Thrombus;Tissues;translational potential;Trauma;Trauma patient;Treatment Failure;vesicular release;Work

PROJECT_TITLE: Inflammasome activation in trauma-hemorrhagic shock

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: HONOLULU

ORG_NAME: EXPERIAD, LLC

ORG_STATE: HI

PHR: PROJECT NARRATIVE This proposal will result in a major new clinical decision support software system, Acuity, which will assist Behavior Analysts in the delivery of Applied Behavior Analysis (ABA), which is the leading treatment for autism. Acuity will integrate with existing ABA software that the clinics are using to collect data and view charts. Acuity will offering significant improvements in treatment planning, progress tracking, trend monitoring, dosage management, and staff assessment.

PI_NAMEs: JAKOBOVITS, REX M (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Accountability;Adherence;Adopted;Adoption;applied behavior analysis;autism spectrum disorder;autistic children;Behavior;Calibration;Clinic;Clinical;Clinical Data;clinical decision support;Clinical Decision Support Systems;cohort;Computer software;dashboard;Data;Data Collection;design;dosage;effective therapy;Evaluation;Evaluation Studies;Exhibits;falls;Frequencies;Future;Generations;Goals;Helping Behavior;Impact evaluation;implementation design;implementation outcomes;improved;insight;machine learning algorithm;member;Monitor;Outcome Study;Performance;Phase;Population;Productivity;programs;Provider;recruit;Research;Schedule;software development;software systems;Statistical Algorithm;success;Supervision;System;Time;timeline;treatment planning;Treatment Protocols;trend;Work

PROJECT_TITLE: Acuity - A Clinical Decision Support System for Applied Behavior Analysis


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: BIRMINGHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative While RNA splicing is a necessary part of proper cellular function in humans, errors in RNA splicing can lead to a large number of human diseases. It is estimated that nearly 50% of genetic mutations associated with human diseases including cardiomyopathies, early onset Parkinson's Disease, and various cancers involve splicing errors. In this project, I propose to determine molecular-level events that guide the selection of splice sites, thereby facilitating the development of treatments for splicing-related diseases.

PI_NAMEs: DURAN, ELIZABETH C (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Active Sites;Address;Alternative Splicing;ATP Hydrolysis;Biochemical;biophysical techniques;Biophysics;C-terminal;Cardiomyopathies;career;Catalysis;Catalytic Domain;Cell Physiology;Charge;Code;Complex;cyanine dye 5;Data;Development;Dilated Cardiomyopathy;Disease;DNA Sequence Alteration;Docking;Dysmyelopoietic Syndromes;early onset;Environment;Enzymatic Biochemistry;Esterification;Event;Exons;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;fluorophore;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Health;Hela Cells;helicase;Human;human disease;Immobilization;Immunoglobulin Joining Region;Impairment;insight;Institution;Introns;Investigation;Kinetics;Knowledge;Label;Laboratories;Ligation;Macromolecular Complexes;Malignant Neoplasms;Mediating;Messenger RNA;Methods;Microscopy;Molecular;Molecular Biology;Molecular Chaperones;Molecular Conformation;Molecular Machines;Monitor;mRNA Precursor;Mutate;Mutation;Nuclear;Nuclear Extract;Nucleotides;Organism;Parkinson Disease;post-doctoral training;posttranscriptional;preference;Process;Progeria;protein complex;Proteins;Rationalization;Reaction;real time monitoring;recruit;Reporter;Reporting;Research;Resolution;RNA;RNA Processing;RNA Splicing;RNA, Messenger, Splicing;Role;Running;single molecule;Site;Small Nuclear RNA;Specificity;Spectrum Analysis;Spliceosome Assembly Pathway;Spliceosomes;Structure;Substrate Interaction;Substrate Specificity;Surface;Syndrome;Testing;therapy development;Training;Transcription Process;U5 small nuclear RNA;UBE2D2 gene;Untranslated RNA;Variant;Work;Yeasts

PROJECT_TITLE: Protein-driven dynamics of pre-mRNA splicing catalysis through single molecule microscopy


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: This K99/R00 proposal will investigate early developmental determinants and pathways in Down syndrome. We will characterize the developmental dynamics between early phenotypic impairments in motor and attention during infancy and examine their mutual or distinct role in communication and cognitive outcomes using a multimethod biobehavioral approach. Results from these studies will constitute advanced phenotyping approaches to better understand the developmental complexity in Down syndrome.

PI_NAMEs: WILL, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Achievement;Affect;Area;Attention;attentional control;Award;Behavior;Behavioral;biobehavior;career;Childhood;Cognition;Cognitive;cognitive function;cognitive skill;Collaborations;Communication;Communication impairment;Complex;computerized data processing;Development;Developmental Process;Dimensions;discount;discrete time;Down's Syndrome;Early Diagnosis;Ensure;Genetic Diseases;Goals;Heart Rate;heart rate variability;Impaired cognition;Impairment;improved;infancy;Infant;Infant Development;innovation;insight;Intellectual functioning disability;Intervention;Investigation;kinematics;Learning;Life;Link;Longitudinal Studies;Measurement;Mentors;Methodology;Methods;Modeling;Motor;motor impairment;Musculoskeletal Equilibrium;Nature;novel;Outcome;Pathogenesis;Pathway interactions;Phase;Phenotype;Physiological;Posture;Prevalence;Process;programs;Research;Resources;Risk;Role;Scientist;Series;Severities;Stimulus;Strategic Planning;success;Testing;Time;Training;United States National Institutes of Health;virtual

PROJECT_TITLE: Early Developmental Determinants and Pathways in Down syndrome


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: ALEXANDRIA

ORG_NAME: AMERICAN INDIAN HIGHER EDUCATION CONSRTM

ORG_STATE: VA

PHR: AIHEC BIRCH Overall Core Project Narrative Each component of the AIHEC BIRCH project is designed to significantly advance Tribal College and University (TCU) efforts to strengthen education and research partnerships that will enable American Indian and Alaska Native (AIAN) students, Tribes, and tribal communities to address Native health disparities, thereby furthering NIH’s mission to address health disparities. The project expands health sciences career pathways for AIAN students, providing professional development opportunities for TCU faculty to engage in Indigenous health research, and conducting vital AIAN health research. Through our intentional partnerships, effective AIAN community-based research and intervention methodologies will be developed, tested, adapted to the unique cultural and place-based context of tribes and communities, and disseminated.

PI_NAMEs: NADEAU, MELANIE ;PHILLIPS, JOHN  (contact)

PROGRAM_OFFICER_NAME: BISSONETTE, GREG

PROJECT_TERMS: Address;Alaska Native;American Indian community;American Indians;Benchmarking;Budgets;career;Career Choice;career development;certificate program;Clinical Trials;Collaborations;Communication;Communities;community based research;Community Health Education;Community Networks;community partners;Country;curriculum development;design;Development;Diabetes Mellitus;Documentation;Education;Educational Curriculum;Educational workshop;empowerment;Enrollment;Equity;Evaluation;expectation;experience;Faculty;Faculty Recruitment;Failure;falls;Frequencies;Goals;graduate student;Health;Health Care Visit;health disparity;Health Personnel;health science research;Health Sciences;Health Services;Healthcare;higher education;Homicide;Human Resources;Hybrids;improved;Indigenous;indigenous community;Infrastructure;Injury;interest;Intervention;Interview;Knowledge;Leadership;Learning;Measurable;Mentors;Methodology;Mission;Modification;mortality;Native-Born;non-Native;Outcome;outreach;Ownership;pandemic disease;Participant;participant interview;Performance;Persons;Process;Program Evaluation;programs;Provider;Publications;recruit;Reporting;Research;research faculty;research in practice;Research Personnel;Resources;Risk;satisfaction;Science;Series;Site;Student Persistence;Student recruitment;Students;Substance Use Disorder;success;Suicide;summer institute;Surveys;symposium;Testing;therapy development;Time;timeline;Training;Travel;treatment adherence;tribal college;tribal community;tribal healthcare;tribal Nation;Tribes;United States National Institutes of Health;virtual;Vision;webinar

PROJECT_TITLE: American Indian Higher Education Consortium (AIHEC) Building Indigenous Research Capacity in Health (BIRCH) project


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

PI_NAMEs: BILLY, CARRIE LYNN (contact)

PROJECT_TERMS: Address;Advisory Committees;Alaska Native;American Indian community;American Indians;Benchmarking;Budgets;career;Career Choice;Clinical Trials;Collaborations;Communication;Communities;community based research;Community Networks;Country;curriculum development;design;Development;Diabetes Mellitus;Education;empowerment;Equity;Evaluation;Faculty;Goals;Health;Health Care Visit;health disparity;Health Personnel;Health Professional;health science research;Health Sciences;Health Services;Healthcare;higher education;Homicide;improved;Indigenous;indigenous community;Information Dissemination;Infrastructure;Injury;Internet;Intervention;Knowledge;Leadership;Mainstreaming;Measurable;meetings;member;Mentors;Methodology;Mission;Monitor;mortality;Native-Born;non-Native;Outcome;Ownership;Performance;Persons;Phase;Process;programs;Provider;recruit;Reporting;Research;research in practice;Research Personnel;Resource Sharing;Resources;Science;science education;Students;Substance Use Disorder;Suicide;Testing;therapy development;Time;timeline;treatment adherence;tribal college;tribal community;tribal healthcare;tribal Nation;Tribes;United States National Institutes of Health;Universities;Vision;webinar

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-N]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

PHR: AIHEC BIRCH Overall Core  Project Narrative  Each component of the AIHEC BIRCH project is designed to significantly advance Tribal College and  University (TCU) efforts to strengthen education and research partnerships that will enable American Indian  and Alaska Native (AIAN) students, Tribes, and tribal communities to address Native health disparities, thereby  furthering NIH’s mission to address health disparities. The project expands health sciences career pathways  for AIAN students, providing professional development opportunities for TCU faculty to engage in Indigenous  health research, and conducting vital AIAN health research. Through our intentional partnerships, effective  AIAN community-based research and intervention methodologies will be developed, tested, adapted to the  unique cultural and place-based context of tribes and communities, and disseminated.

PI_NAMEs: WARNE, DONALD KEITH (contact)

PROJECT_TERMS: Accreditation;Address;Alaska Native;American Indian community;American Indians;Associate Degree;Biometry;career;Career Choice;career development;Clinical Trials;Collaborations;college;Communities;community based participatory research;community based research;Community Networks;Country;Data;Data Collection;design;Development;Diabetes Mellitus;Discipline;Doctor of Philosophy;Education;Educational Curriculum;Educational process of instructing;Educational workshop;empowerment;Endowment;Epidemiology;Equity;Evaluation;Evidence based intervention;experience;Faculty;faculty mentor;Federal Government;Financial Support;Fostering;Frequencies;Funding;Goals;Health;Health Care Visit;health disparity;Health Personnel;health science research;Health Sciences;Health Services;higher education;Homicide;improved;Indigenous;indigenous community;Infrastructure;Injury;Institution;instructor;Intervention;Knowledge;Learning;meetings;member;Mentors;Methodology;Minority Groups;Mission;mortality;Native-Born;non-Native;North Dakota;Outcome;Ownership;Participant;Persons;Positioning Attribute;Process;Program Evaluation;programs;Provider;Public Health;Publications;recruit;Research;Research Activity;research faculty;research in practice;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Resources;Science;Scientist;skills;Students;Substance Use Disorder;success;Suicide;symposium;Testing;therapy development;treatment adherence;Treaty;tribal college;tribal community;tribal healthcare;tribal Nation;Tribally Based Participatory Research;Tribes;Trust;United States National Institutes of Health;Universities;virtual;Vision;Work


PHR: Project Narrative The vision of the American Indian Higher Education Consortium’s (AIHEC) “Building Indigenous Research Capacity in Health” (BIRCH) project is sovereign Tribal Nations asserting full ownership, direction, and control of the health research needed to help their people grow healthy and strong. Implementing new programs in the 37 TCUs across the country, AIHEC will provide additional resources for American Indian and Alaska Native (AIAN) students to pursue coursework and careers that will enable them to act as healthcare providers and researchers. This project provides a comprehensive approach to growing a networked community of AIAN and non-Native researchers, educators, and community practitioners to implement traditional knowledge practices in addressing AIAN health issues and continuously improve Native health and health research practices and outcomes. The lack of tribal healthcare researchers and providers perpetuates health disparities and a lack of equity in tribal communities. Furthermore, studies show that communities with tribal healthcare providers and researchers have a higher treatment adherence and fewer mortalities or serious illnesses. Promoting the advancement of AIAN students will not only benefit the students. Still, it will also lead to healthier tribal communities, increased compliance with healthcare visits and interventions, participation in clinical trials, and a reduction in the primary causes of illness and mortality such as diabetes, substance use disorders, injuries, homicide, and suicide. The long-term goals of the project are: To expand a community of Indigenous research practice in health/health sciences at the nation’s TCUs; to establish TCUs as essential tribally-centered components of the national health sciences research and education infrastructure; to improve the quality of health services provided to AIANs using a science-based empirical approach to intervention development and evaluation that is relevant to Native peoples and communities and based on core tribal values, cultures, and traditions; to expand the TCU component of the health research and education career pipeline to recruit, support, and provide critical linkages for AIAN students to pursue health careers; to empower tribes and tribal communities to develop and control their research agenda and connect that research to tribal values and needs, and to promote the integration of Indigenous knowledge and Western knowledge.

PI_NAMEs: CHARETTE, RENO L (contact)

PROJECT_TERMS: Address;Alaska Native;American Indian community;American Indians;Biological Sciences;career;career development;Career Exploration;Case Study;Clinical Trials;Communities;Community Networks;Country;Course Content;COVID-19;design;Development;Diabetes Mellitus;Education;Educational process of instructing;Educational workshop;Elements;empowerment;Epidemiology;Equity;Evaluation;expectation;experience;Faculty;Focus Groups;Future;Goals;graduate student;Group Interviews;Health;Health Care Visit;health disparity;Health Personnel;health science research;Health Sciences;Health Services;higher education;Homicide;Hybrids;improved;Indigenous;indigenous community;Individual;infection rate;Infrastructure;Injury;Instruction;interest;Intervention;Interview;Knowledge;Learning;learning materials;learning outcome;Logistics;meetings;member;Mentors;Modification;mortality;Native-Born;non-Native;online delivery;Outcome;outreach;Ownership;pandemic disease;Participant;Persons;programs;Provider;recruit;Research;research in practice;Research Personnel;Resources;response;Risk;satisfaction;Schedule;Science;Specialist;Student Persistence;Student recruitment;Students;Substance Use Disorder;success;Suicide;summer institute;Surveys;symposium;System;therapy development;Time;Travel;treatment adherence;tribal community;tribal healthcare;tribal Nation;Tribes;United States Indian Health Service;Vision;web site;webinar;Work


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE Diseases result when the internal stability and normal communications within and among biological pathways are disrupted by genetic defects, environmental disturbances, or pathogens. The Nebraska Center for Integrated Biomolecular Communication (CIBC) integrates the research activities of chemists, biochemists, engineers, and bioinformaticians to address critical knowledge gaps in our understanding of how cells communicate and integrate metabolic and regulatory pathways relevant to complex disease development and progression. CIBC investigators will continue to bring together unique expertise in the understanding of complex diseases and in the development of novel methodologies and technologies to probe communication pathways. 1

PI_NAMEs: GUO, JIANTAO  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Address;Area;Award;Bioinformatics;Biological;Biological Sciences;Biomedical Research;Biosensing Techniques;career development;CARTPT gene;Cell Communication;Cells;Chemicals;Chromatin;cohort;Collaborations;college;Communication;Communities;Complex;computational platform;Computer Models;Core Facility;Cryoelectron Microscopy;Data;Data Analyses;data management;data mining;data portal;Data Science;data sharing;design;Detection;Development;Diagnosis;Discipline;Disease;Disease Pathway;E-learning;Educational workshop;Engineering;Equipment;Evaluation;Faculty;Fostering;Fourier transform ion cyclotron resonance;Funding;Genetic Transcription;Goals;Grant;human disease;imaging capabilities;improved;innovation;Interdisciplinary Communication;Interdisciplinary Study;International;Knowledge;Mass Spectrum Analysis;Medical center;member;Metabolic Pathway;methicillin resistant Staphylococcus aureus;Methodology;Methods;Molecular;Molecular Probes;multidisciplinary;Mutation;Nature;Nebraska;new technology;novel;novel therapeutic intervention;Outcome;Outcomes Research;pathogen;Pathway interactions;Peer Review;Peptides;Phase;Physiological;Pilot Projects;Positioning Attribute;Problem Solving;Publications;rational design;receptor;recruit;Regulation;Regulatory Pathway;Research;Research Activity;Research Infrastructure;Research Personnel;Research Support;Secure;Series;Services;Statistical Data Interpretation;structural biology;success;System;Systems Biology;Techniques;Technology;Time;Training;training opportunity;treatment strategy;Universities;unnatural amino acids;Water


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Advisory Committees;Biochemical Pathway;Biology;Biomedical Research;career development;Cells;Centers of Research Excellence;Chemicals;Collaborations;Communication;Complex;Dedications;Development;Development Plans;Disease;Disease Pathway;Educational workshop;Ensure;Environment;Evaluation;Faculty;Fostering;Funding;Goals;graduate student;Grant;Growth;Health;Homeostasis;improved;Individual;informatics tool;Infrastructure;Institution;Interdisciplinary Study;Intervention;Leadership;Life;macromolecule;member;Mentors;Molecular;Molecular Probes;Nebraska;novel;operation;organizational structure;Outcome;Pathway interactions;Persons;Phase;Population;Postdoctoral Fellow;prevent;Process;Program Research Project Grants;programs;recruit;Regulation;Research;research and development;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Support;Role;Route;Secure;Structure;success;symposium;Talents;Techniques;Technology;therapy development;Tissues;Training;Travel;undergraduate student;United States;Universities;Vision

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: SYRACUSE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative Fetal Alcohol Spectrum Disorders (FASD) and is estimated to occur in up to 5% of live births per year in the US and is characterized by physical, cognitive and behavioral impairments. The proposed study seeks to examine novel molecular mechanisms through which prenatal alcohol exposure might cause craniofacial and brain abnormalities. These experiments are important for our understanding of how prenatal alcohol exposure causes birth defects in the human population and will aid in the identification of potential therapeutic targets for the treatment of FASD.

PI_NAMEs: BOSCHEN, KAREN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Address;Affect;alcohol exposure;Alcohols;Apoptotic;behavioral impairment;brain abnormalities;cdc Genes;Cell Cycle;Cell Cycle Arrest;Cell Cycle Kinetics;Cell Cycle Progression;Cell Cycle Regulation;Cell Cycle Stage;cell determination;Cell Differentiation process;cell preparation;Cell Proliferation;Cell Separation;Cells;ChIP-seq;Chromatin;chromatin modification;Cilia;Congenital Abnormality;Corpus striatum structure;Craniofacial Abnormalities;Data;Development;Differentiation Antigens;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;Dose;Embryo;embryonic alcohol exposure;Enzymes;Epigenetic Process;epigenetic regulation;epigenome;experimental study;Exposure to;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Flow Cytometry;G1/S Transition;Gene Expression Regulation;gene network;gene repression;Genes;genome-wide;Goals;Growth;Histones;Hour;Human;human disease;Image;Impaired cognition;Impairment;innovation;insight;Life;Live Birth;Modification;Molecular;mouse model;Mus;Neural tube;Neural Tube Closure;Normal Cell;novel;novel strategies;organ growth;Pathogenicity;Pathway interactions;physical impairment;Pituitary Gland;Ploidies;Population;Post-Translational Protein Processing;Pregnancy;premature;prenatal;Process;Proliferating;Prosencephalon;protein degradation;Protein Dynamics;protein expression;protein protein interaction;protein transport;Proteins;Replication Error;response;Sampling;Signal Transduction;Site;Sonic Hedgehog Pathway;Structure;Sumoylation Pathway;Symptoms;Techniques;Testing;therapeutic target;therapy development;Tissues;transcriptome sequencing;transcriptomic profiling;Transforming Growth Factor beta;Ubiquitin;Visualization;Work

PROJECT_TITLE: Cell cycle regulation in Fetal Alcohol Spectrum Disorders


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: POWERS, ROBERT  (contact)

PROJECT_TERMS: Address;Adopted;Adoption;Applications Grants;Automation;Back;base;Biological Sciences;Client;Collaborations;collaborative approach;Communication;Communications Personnel;complex biological systems;Computer software;Conceptions;Core Facility;Data;Data Science;Dissemination and Implementation;E-learning;Education and Outreach;Educational workshop;Electron Microscopy;Ensure;experience;Experimental Designs;Fee-for-Service Plans;Fees;Goals;Growth;Human Resources;imaging capabilities;improved;Industrialization;Information Dissemination;Infrastructure;instructor;instrumentation;Investments;lipidomics;Liquid substance;mass spectrometric imaging;Mass Spectrum Analysis;member;metabolomics;Methods;Microscopy;Modeling;Molecular Analysis;Nebraska;novel;Nuclear Magnetic Resonance;organizational structure;Outcome;outreach services;Phase;Philosophy;Preparation;Procedures;programs;Proteomics;Protocols documentation;Publications;Research;research facility;Research Personnel;response;RNA;Sampling;Series;Service delivery model;Services;software development;Specialist;structural biology;Structure;success;sustainable resource;System;Systems Biology;Techniques;Technology;Training;training opportunity;training project;Universities;Vision;Wages

PROJECT_TITLE: Systems Biology Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative  Mapping the complex wiring between neurons can help us understand how brain circuits work a fundamental level, but is not possible with current imaging technologies. In this project, we will develop a synchrotron-based X-ray imaging approach that has the potential to enable rapid brain-wide circuit mapping. This new imaging technology will contribute to a mechanistic understanding of human cognition and the development of cures for psychiatric diseases.

PI_NAMEs: KUAN, AARON  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: Affect;Algorithms;anatomic imaging;Anatomy;Area;Atlases;Auditory area;Axon;beamline;Biological Models;Brain;Brain imaging;Brain Mapping;Calcium;Cells;Cognition;cognitive function;Complex;convolutional neural network;Data;Data Set;Decision Making;deep learning;Detection;detector;Development;Electron Microscopy;European;experimental study;Functional Imaging;Generations;Geometry;Goals;high resolution imaging;Holography;Human;Image;image reconstruction;imaging approach;imaging capabilities;imaging modality;Imaging Techniques;Imaging technology;improved;in vivo;Individual;insight;Label;Length;light microscopy;Machine Learning;machine vision;Maps;Mediating;Mental disorders;microscopic imaging;millimeter;Morphology;multimodal data;multisensory;Mus;nano;nanoimaging;nanoscale;Neocortex;neural circuit;neuronal circuitry;Neurons;Neurosciences;Outcome;Parietal Lobe;Performance;Protocols documentation;reconstruction;Reporter;Resolution;Roentgen Rays;sample fixation;Sampling;segmentation algorithm;sensor;Sensory;sensory input;software development;Software Tools;Source;Speed;Stains;support network;Synapses;Synchrotrons;Techniques;Tissue Sample;Tissues;tool;Training;two-photon;Visual Cortex;Visualization;white matter;Work;X-Ray Medical Imaging

PROJECT_TITLE: Brain-wide Neuronal Circuit Mapping with X-ray Nano-Holography


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Calcium signaling helps maintain normal cellular functions, but pathogens, including intestinal viruses like rotavirus, reprogram normal cellular calcium pathways to commandeer cellular machinery for their replication, which results in potentially life-threatening diseases like diarrhea. We recently discovered that rotavirus infection triggers long-distance signaling that also increases calcium in surrounding uninfected cells in the gut. This proposal investigates how this long-distance calcium signal is involved in host responses to rotavirus- induced damage but also exploited by rotavirus to increase its replication and spread.

PI_NAMEs: HYSER, JOSEPH M. (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: 5 year old;Acute;Affect;Anions;Anti-viral Response;Anti-viral Therapy;Antidiarrheals;arms race;Autophagocytosis;Binding;Biochemical;Biological Response Modifiers;Calcium;Calcium Oscillations;Calcium Signaling;Cell Line;Cell Physiology;cell type;Cells;cellular targeting;Cessation of life;Child;Chlorides;clinically relevant;Complex;cytokine;Data;Diarrhea;Disease;Distal;Endoplasmic Reticulum;Enteral;enteric pathogen;enteric virus infection;Epithelium;Fluids and Secretions;Functional disorder;Funding;Gastroenteritis;gastrointestinal;Gastrointestinal tract structure;Genetic;Genetic Transcription;Goals;Human;Image;imaging approach;Imaging Techniques;Immune response;Infection;insight;Intestines;Knock-out;Life;Link;MAP Kinase Gene;Measures;Mediating;Modeling;Molecular Biology;mortality;Nature;new therapeutic target;Nonstructural Protein;novel;Organoids;Outcome;paracrine;pathogen;Pathogenesis;Pathway interactions;Physiological;Play;programs;Proviruses;Purinoceptor;purinoceptor P2Y1;Recombinants;repaired;response;Reticulum;Role;Rotavirus;Rotavirus Infections;Serotonin;Signal Pathway;Signal Transduction;stem cell biomarkers;Testing;transcriptomics;vaccine access;Villus;Viral;Virus;virus host interaction;Virus Replication

PROJECT_TITLE: Enteric virus exploitation of calcium signaling

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: TAKACS, JAMES M (contact)

PROJECT_TERMS: Address;base;Biochemical;Bioinformatics;Biological;Biological Sciences;biomedical data science;Biomedical Research;Biotechnology;Chemicals;cohort;Collaborations;Collection;Communication;Communication Research;Communities;Complex;complex data;Computational Biology;computational pipelines;computational platform;computer science;Computer software;Core Facility;cost;cost effective;Cryoelectron Microscopy;cyber infrastructure;Data;Data Analyses;data exchange;data infrastructure;data management;Data Management Resources;data pipeline;data portal;Data Science;Data Science Core;data science resource;Data Set;Data Storage and Retrieval;Development;Education;Educational workshop;Electron Microscopy;Equipment;Experimental Designs;experimental study;Faculty;FAIR principles;Fee-for-Service Plans;Fees;Funding;Generations;Goals;Grant;Human Resources;Image;improved;Individual;Infrastructure;Internet;knowledge base;Laboratories;Libraries;light microscopy;Link;Manuscripts;member;Molecular Biology;molecular imaging;Nebraska;Outcome;Pathway interactions;Peer Review;Phase;Public Health;Publications;Research;research facility;Research Personnel;Resources;Role;Services;Statistical Data Interpretation;statistics;structural biology;sustainable resource;Technical Expertise;tool;Training;Universities;web page;web portal;webinar;Workforce Development;x-ray free-electron laser

PROJECT_TITLE: Light and Electron Microscopy Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

PHR: PUBLIC HEALTH RELEVANCE In low-resource settings, high rates of perinatal mortality are due in part to challenges accessing affordable technologies to screen and monitor high-risk maternal-fetal conditions, such as intrauterine growth restriction and preeclampsia. To address these issues, we will use artificial intelligence to develop techniques for predicting intrauterine growth restriction and preeclampsia from low-cost hand-held maternal and fetal Doppler recordings. This will represent a major step forward in affordable and scalable technology for pregnancy monitoring in low-resource settings around the globe.

PI_NAMEs: CLIFFORD, GARI DAVID (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Acceleration;Address;Algorithms;Artificial Intelligence;Birth;Blood Pressure;Caring;Cellular Phone;Childhood;clinical risk;Code;cohort;Computer Systems;cost;cost effective;Country;Data;data exchange;Death Rate;deep learning algorithm;Detection;Development;Devices;diagnostic accuracy;diagnostic platform;diagnostic strategy;diagnostic tool;diagnostic value;Disparity;Doppler Ultrasound;empowerment;fetal;Fetal Development;Fetal Growth;Fetal Growth Retardation;Fetal Heart Rate;fetal medicine;field study;Foundations;Frontline worker;Funding;Gestational Age;Goals;Guatemala;Health;Health system;heart rate variability;high risk;High-Risk Pregnancy;Hypertension;Image;Improve Access;improved;Income;Infant;innovation;International;Knowledge;Label;Life;long short term memory;low and middle-income countries;Machine Learning;Maternal Health;maternal hypertension;Maternal Mortality;maternal risk;Medical;Mission;Monitor;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;neonatal health;Neonatal Mortality;neural network;novel;novel strategies;Observational Study;Outcome;Patients;Perinatal mortality demographics;perinatal outcomes;point of care;Population;Pre-Eclampsia;predictive tools;Pregnancy;Pregnancy Complications;pregnancy disorder;Prenatal care;prevent;Process;prospective;public health relevance;Research;Resource-limited setting;Resources;risk prediction model;Running;Rural;screening;Signal Transduction;standard of care;stillbirth;System;Techniques;Technology;technology validation;Time;Training;Transducers;Triage;tv watching;two-dimensional;ultrasound;Underserved Population;Validation;Work

PROJECT_TITLE: AI-driven low-cost ultrasound for automated quantification of hypertension, preeclampsia, and IUGR

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurodegenerative;Neurosciences;Regenerative Medicine

PI_NAMEs: HUANG, YIHE  (contact);TAKACS, JAMES M

PROJECT_TERMS: Adult;Alzheimer's Disease;atomic interactions;Biophysics;Brain;Cell membrane;Cells;central nervous system injury;Communication;Complex;Cryoelectron Microscopy;Degenerative Disorder;Development;Disease;Elements;Event;extracellular;Foundations;Future;Goals;Homologous Gene;Human;Impairment;Injury;Knowledge;Ligands;Location;Maintenance;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Medical;Membrane;Molecular;Natural regeneration;Nebraska;Neurodegenerative Disorders;neurogenesis;Neurons;next generation;novel;Parkinson Disease;particle;Pathologic;Pathway interactions;Physiological;Play;programs;Proteins;rational design;receptor;regenerative therapy;Research;Role;Side;Signal Pathway;Signal Transduction;Signal Transduction Induction;Source;Specificity;stem cell division;Structure;Synaptic plasticity;Therapeutic;Time;Tissues;Visualization;WNT Signaling Pathway

PROJECT_TITLE: CryoEM studies of Wnt3a-FZD8-LRP6 signaling complex in neurogenesis and regeneration


ADMINISTERING_IC: MD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: DURHAM

ORG_NAME: NORTH CAROLINA CENTRAL UNIVERSITY

PHR: Narrative Racial and ethnic health disparities in the US have been made worse by COVID19, thus, increasing its awareness and its need to be addressed. The role of HBCUs in addressing and being represented in the community has proven to be essential to the resolution of these disparities. Through this competitive renewal, NCCU's RCMI Center for Health Disparities Research (RCHDR) will continue enhancing NCCU's research ecosystem to develop successful scientists conducting impactful and cutting-edge research to address health disparities (HD) and achieve health equity.

PI_NAMEs: HARRINGTON, CHERISE BALDWIN;KUMAR, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Address;Advisory Committees;Area;Automobile Driving;Award;Awareness;Behavioral;behavioral health;Behavioral Research;Behavioral Sciences;Biomedical Research;Biotechnology;Collaborations;Communities;community engagement;community organizations;community partnership;County;COVID-19;COVID-19 disparity;COVID-19 pandemic;COVID-19 testing;Cues;Data;Development;Disparity;Dissemination and Implementation;Doctor of Philosophy;Economics;Ecosystem;Education;Equity;ethnic health disparity;Evaluation;experience;Extramural Activities;Fostering;Funding;Grant;Health;Health Disparities Research;health disparity;health equity;health inequalities;Healthcare;Historically Black Colleges and Universities;Individual;Infrastructure;innovation;Institution;Institutionalization;interest;International;Investments;Leadership;Learning;Malignant Breast Neoplasm;meetings;Mentors;Minority Groups;Mission;National Institute of Environmental Health Sciences;National Institute on Minority Health and Health Disparities;North Carolina;pandemic disease;Pilot Projects;population health;post-pandemic;Postdoctoral Fellow;programs;Publications;racial health disparity;Renaissance;Research;Research Institute;Research Personnel;Research Project Grants;Resolution;Resource Sharing;Resources;Role;Rural;rural underserved;Scientist;Social Distance;Structural Racism;tenure track;underserved community;United States National Institutes of Health;Universities;urban underserved;Vaccination;vaccine hesitancy;Vaccines;virtual;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: KUMAR, DEEPAK  (contact)

PROJECT_TERMS: Address;Advisory Committees;Area;Automobile Driving;Award;Behavioral;behavioral health;Behavioral Research;Behavioral Sciences;Biomedical Research;Biotechnology;career;career development;Collection;Common Data Element;Communities;community advisory board;community engagement;community organizations;Core Facility;COVID-19;COVID-19 disparity;COVID-19 pandemic;data sharing;Decision Making;Development;Discipline;Dissemination and Implementation;Doctor of Philosophy;Ecosystem;Educational workshop;Ensure;Environment;Evaluation;evidence base;experience;Extramural Activities;Faculty;Focus Groups;Fostering;Funding;Goals;Grant;growth promoting activity;Health;Health Disparities Research;health disparity;improved;Individual;Infrastructure;innovation;Institution;Institutionalization;Investments;Leadership;Logistics;Minority Groups;Minority-Serving Institution;Mission;Monitor;National Institute on Minority Health and Health Disparities;next generation;North Carolina;Outcome;Peer Review;Pilot Projects;population health;Postdoctoral Fellow;practice-based research network;Process;process improvement;Productivity;programs;Public Health;Publications;recruit;Research;Research Activity;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Resources;response;Rural;success;synergism;tenure track;Underrepresented Populations;United States National Institutes of Health;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

PHR: Project Narrative – Project 1 Black women suffer disproportionately from breast cancer mortality, with social, environmental and biological causes. We propose to identify mechanisms by which metastatic breast carcinomas tend to be more common in Black women, focusing on cell-cell interactions between the cells that surround the tumor and the tumor itself. This research will provide a basis for developing new methods for targeting these aggressive breast cancers.

PI_NAMEs: WILLIAMS, KEVIN PETER (contact)

PROJECT_TERMS: Age disparity;aggressive breast cancer;Anthropology;Automobile Driving;Biological;Biological Markers;Black race;black women;Breast;Breast Cancer cell line;Breast Cancer Patient;breast cancer progression;Breast Cancer Risk Factor;Breast Carcinoma;cancer diagnosis;cancer health disparity;Cancer Prognosis;cancer subtypes;cancer type;Cancerous;Cell Communication;cell type;Cells;Cessation of life;Characteristics;Clinical;Collaborations;comparative;complex data;Data;Data Set;Death Rate;defined contribution;Deoxyadenosines;Detection;Diagnosis;digital;Disparity;DNA Repair;driving force;effective therapy;Elements;epidemiology study;ethnic diversity;Etiology;experimental study;Frequencies;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Polymorphism;genetic signature;Genomic Instability;Goals;Growth Factor Gene;Growth Factor Overexpression;Health Disparities Research;HGF gene;hormone receptor-negative;Immune;Immunohistochemistry;immunological status;In Vitro;in vivo;Infiltration;inflammatory breast cancer;innovation;Lesion;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Mediator;Metastatic breast cancer;Methods;Molecular;mortality;Mus;Mutagenesis;Mutate;Mutation;nano-string;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Oncogenic;Outcome;outcome disparities;Pathogenesis;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Polymorph;Population Heterogeneity;Prognosis;prognostic;programs;promoter;Promoter Regions;Proteins;Publishing;Race;receptor;Research;Resources;Risk;RNA;Role;Sampling;Sampling Studies;Signal Pathway;Signal Transduction;Site;social;Source;Space Perception;spatial relationship;stemness;Stromal Cells;Survival Rate;targeted treatment;Techniques;Testing;Therapeutic;Tissues;tool;transcriptome sequencing;Transfection;Translating;tumor;tumor growth;tumor heterogeneity;tumor microenvironment;Tumor Subtype;tumor-immune system interactions;tumorigenesis;White Women;Woman;wound healing

PROJECT_TITLE: Immune Microenvironments and Hepatocyte Growth Factor Signaling Interactions in Breast Cancer Disparities


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

PHR: Project Narrative – Project 2 African American/Black (AA/B) young adults are more likely to burdened by excess weight and face multiple disparities and negative health outcomes. The BeFAB-HBCU mHealth intervention serves overweight and obese AA/B young adults and is culturally-specific and tailored. Informed by community stakeholders, this study evaluates BeFAB-HBCU and its impact on behavior, achieving healthy weight, and physical activity.

PI_NAMEs: HARRINGTON, CHERISE BALDWIN (contact)

PROJECT_TERMS: active lifestyle;Address;Adult;African American;African American population;African American Women;Age;aged;allostatic load;American;Amputation;attentional control;Behavior;behavior change;Behavioral;Belief;Biological Markers;Black race;Body mass index;Body Weight;Body Weight decreased;Calories;Cardiovascular Diseases;Chronic Disease;college;Communities;community advisory board;comparison intervention;Consultations;Control Groups;COVID-19 pandemic;critical period;Data;density;design;Development;Diabetes Mellitus;diabetes prevention program;digital;digital technology;Dimensions;disability;Disparity;dosage;Education;Effectiveness;efficacy testing;efficacy trial;Environment;Environmental Risk Factor;ethnic diversity;evidence base;experience;Face;Feedback;Grant;group intervention;Health;Health behavior;Health Care Costs;Health Disparities Research;health disparity;health literacy;Health Promotion;Healthy Eating;healthy weight;Historically Black Colleges and Universities;implementation trial;improved;indexing;Individual;innovation;intergenerational;Intervention;Intervention Trial;Kidney Diseases;Life;life span;Life Style;lifetime risk;Link;Maps;Measures;media use;Mediating;Metabolic;mHealth;mhealth interventions;Minority-Serving Institution;moderate-to-vigorous physical activity;Monitor;mortality;Non-Insulin-Dependent Diabetes Mellitus;North Carolina;Not Hispanic or Latino;novel;nutrition;nutrition related behavior;Obesity;obesity risk;Online Systems;Outcome;Overweight;peer;Persons;Phase;Physical activity;Physiological;Population;Populations at Risk;postpartum weight;Postpartum Women;Prediabetes syndrome;Process;programs;promote resilience;psychosocial;racial diversity;Randomized, Controlled Trials;Reporting;Research;Resources;Risk;Risk Behaviors;Risk Factors;Site;Sleep Deprivation;social;social cohesion;Social Environment;social factors;social media;Social support;sociodemographics;Source;Stress;stress management;Students;success;Techniques;Technology;Testing;Text Messaging;theories;Time;Trust;Universities;university student;Visual impairment;Waiting Lists;web-based intervention;Weight;Weight Gain;weight loss intervention;Weight maintenance regimen;Work;young adult

PROJECT_TITLE: Multi-dimensional Approach to Address Excess Weight and Pre-Diabetes Health Disparities in Young Adults


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KIMBRO, KEVIN SEAN (contact)

PROJECT_TERMS: Address;Advisory Committees;Applications Grants;Area;Award;Behavioral;behavioral health;Biomedical Research;career development;Collaborations;Communication;Communities;community engagement;Complement;COVID-19;COVID-19 disparity;COVID-19 impact;COVID-19 pandemic;Data;Data Collection;design;Development;Doctor of Philosophy;Educational workshop;Ensure;Environment;Ethnic Population;experience;Faculty;Fostering;Foundations;Funding;Goals;Grant;Grant Review;Grant Review Process;Growth;Health;Health Disparities Research;health disparity;health disparity populations;health inequalities;Human;implementation science;Infrastructure;Institution;Institutional Review Boards;instructor;Joints;meetings;Mentors;minority health;minority health disparity;Mission;new growth;pandemic disease;Pilot Projects;population health;Postdoctoral Fellow;professor;Program Development;programs;racial population;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;Scientist;skills;Social Distance;Structure;success;Support Groups;tenure track;Training;Underserved Population;United States National Institutes of Health;virtual;Work;Writing

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

PI_NAMEs: RICHARDSON, MICHELER RICARDO (contact)

PROJECT_TERMS: Address;Advisory Committees;Area;Behavioral;behavioral health;Behavioral Sciences;behavioral study;Biomedical Research;Collaborations;collaborative environment;Communication;community engagement;Community Outreach;Complement;cost;COVID-19 disparity;COVID-19 pandemic;COVID-19 testing;COVID-19 vaccine;Data;Data Analytics;Development;Doctor of Philosophy;Doctor's Degree;Ecosystem;effectiveness research;Ensure;Environment;Equity;Ethics;Ethnic Population;forging;Fostering;Funding;Future;Goals;Grant;Health;health communication;Health Disparities Research;health disparity;health equity;health inequalities;health literacy;Health Services;Health Services Research;Healthcare;higher education;Historically Black Colleges and Universities;Human;Image;Industry;Infrastructure;innovation;Institution;International;Metabolic;Minority Groups;Minority-Serving Institution;Modeling;North Carolina;Pilot Projects;Play;Population;population health;Preparation;Productivity;programs;racial population;Recovery;Renaissance;Research;Research Activity;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Rodent;Role;STEM student;Structure;Suggestion;synergism;Testing;Time;Training;Training and Education;training opportunity;Underrepresented Populations;United States National Institutes of Health;Universities;Vaccination;Vaccines

PROJECT_TITLE: Research Capacity Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Vaccine Related

PHR: Narrative Racial and ethnic health disparities in the US have been made worse by COVID19, thus, increasing its awareness and its need to be addressed. The role of HBCUs in addressing and being represented in the community has proven to be essential to the resolution of these disparities. Through this competitive renewal, NCCU’s RCMI Center for Health Disparities Research (RCHDR) will continue enhancing NCCU’s research ecosystem to develop successful scientists conducting impactful and cutting-edge research to address health disparities (HD) and achieve health equity.

PI_NAMEs: TAYLOR, LORRAINE C. (contact)

PROJECT_TERMS: Address;Advocate;Affect;age group;Area;Awareness;Caring;Communities;community building;community engagement;Community Health;Community Networks;community organizations;Community Participation;community partners;community partnership;community research;community-centered;Complex;Consultations;County;COVID-19;COVID-19 disparity;COVID-19 impact;COVID-19 pandemic;COVID-19 testing;COVID-19 vaccination;COVID-19 vaccine;cultural competence;data sharing;Development;Disparity;Dissemination and Implementation;dissemination strategy;Doctor of Philosophy;Ecosystem;Education;education research;Educational workshop;Effectiveness;Ethics;ethnic diversity;ethnic health disparity;Event;Evidence based practice;Faculty;Food;Fostering;Foundations;Funding;Goals;Health;health communication;Health Disparities Research;health disparity;health equity;Health Fairs;health inequalities;health literacy;Health Promotion;Health Services;Healthcare;Historically Black Colleges and Universities;improved;Infrastructure;innovation;interest;Lived experience;medically underserved;Medically Uninsured;member;minority communities;Modeling;Needs Assessment;Neighborhood Health Center;North Carolina;outreach;pandemic disease;pandemic impact;Personal Satisfaction;Persons;Pilot Projects;Politics;Primary Care;Public Health;racial diversity;racial health disparity;recruit;Research;Research Activity;research and development;research faculty;Research Personnel;Research Project Grants;Resolution;response;Role;satisfaction;Scientist;screening;service intervention;sexual identity;social;social health determinants;Source;Testing;theories;therapy development;Translations;Trust;underserved community;United States National Institutes of Health;Universities;Vaccination;vaccine hesitancy;Vulnerable Populations;Work

PROJECT_TITLE: Community Engagement Core


ADMINISTERING_IC: AI

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE Chronic hepatitis B virus (HBV) infection is a global public health burden that affects approximately 300 million individuals worldwide, and there is consensus in the field that having better small animal models to study HBV immunopathogenesis would speed the development of curative therapies. The goal of this proposed research is to leverage host and viral diversity to breach the species barrier for HBV infection in murine hepatocytes. These efforts will yield new insights into HBV tropism and facilitate the development of immunocompetent, HBV- susceptible animal models for chronic hepatitis B.

PI_NAMEs: RICE, CHARLES M (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Animal Model;anti-hepatitis B;Capsid;Cell Culture Techniques;Cells;Chronic Hepatitis B;Circular DNA;Consensus;Core Protein;curative treatments;Data;design;Development;Ectopic Expression;Engraftment;Environment;exhaustion;Exhibits;experimental study;Failure;FDA approved;Fostering;functional genomics;Genes;Genetic;Genetic Transcription;Genetic Variation;Genome;Genomic approach;Goals;Hepatitis B Virus;Hepatocyte;hepatoma cell;high reward;Human;human disease;human model;humanized mouse;Immune;Immune response;Immune system;Immunocompetent;immunodeficiency;Immunodeficient Mouse;In Vitro;in vivo;Individual;Infection;insight;Integration Host Factors;Knockout Mice;Libraries;Life Cycle Stages;Literature;Liver;Medical;Methods;Modeling;mouse genetics;mouse model;Mouse Strains;Mus;mutant;Na(+)-taurocholate-cotransporting peptide;Nature;new technology;novel;Nucleocapsid;Outcome;Pan Genus;Patients;permissiveness;Persons;Pharmaceutical Preparations;Physiological;Predisposition;Pregnancy;Preventive vaccine;Public Health;receptor;reproductive;Research;Reverse Transcription;Risk;Role;Scientist;Species Specificity;Speed;System;T-Lymphocyte;Testing;Therapeutic;therapeutic development;transgene expression;Transgenic Mice;Transgenic Organisms;Tropism;Variant;Viral;Viral Genome;viral RNA;Virus;Virus Diseases;Virus Replication;virus tropism;Xenograft procedure

PROJECT_TITLE: Breaching the species barrier: Towards an immunocompetent HBV-susceptible mouse model

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 DF-M (M1)]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Clinical Research;Health Services;Lung;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Social Determinants of Health;Telehealth

ORG_NAME: CANAIRY LLC

PHR: PROJECT NARRATIVE COPD is a common and preventable chronic lung disease, and real-time remote monitoring is necessary to provide individualized care to patients with COPD for seamless long-term care and more cost-effective efforts. Our company is developing a novel product that can revolutionize healthcare for COPD patients by presenting new opportunities for clinicians to care for their patients and reduce hospital readmission while permitting users to monitor respiratory well-being and change behaviors to have immediate health benefits. The proposed technology creates a fully wireless and intelligent wearable sensor for passive monitoring, prompt data access, and alert for daily emergency assessments and medication adjustment, as a result helping maximize patient outcomes while reducing healthcare costs for COPD.

PI_NAMEs: CHAPMAN, TERRY  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Address;Admission activity;Adult;Affect;Air;Air Pollution;Airway Disease;Algorithmic Analysis;Algorithms;Asthma;behavior change;Bluetooth;Calibration;care outcomes;Caring;Cause of Death;Cellular Phone;Chronic lung disease;Chronic Obstructive Pulmonary Disease;climate change;Clinic;Clinic Visits;Code;cohort;commercialization;Computer software;computerized data processing;cost;cost effective;Data;data access;Data Analyses;Data Collection;data communication;data exchange;data exchange system;Data Storage and Retrieval;Decision Making;design;Detection;Development;Devices;Disease;Early identification;Early Intervention;Economic Burden;Emergency department visit;Emergency Situation;Environmental Exposure;Equipment;Exposure to;Eye;field study;Flare;Flowmeters;Focus Groups;graphical user interface;Health;Health Benefit;Health Care Costs;health care quality;health data;Health Personnel;Health Professional;Health Status;Healthcare;healthy lifestyle;high risk;Hospital Costs;hospital readmission;Hospitalization;Hospitals;Housing;improved;innovation;Interruption;Intervention;Knowledge;Lead;Length of Stay;Link;Long-Term Care;Lung;lung health;Marketing;Measures;Medical;medical schools;meetings;Memory;Miniaturization;miniaturize;Monitor;Notification;novel;Observational Study;overtreatment;Participant;Patient Monitoring;Patient-Focused Outcomes;Patients;Performance;Personal Satisfaction;personalized care;Pharmaceutical Preparations;Phase;Physicians;pollutant;power consumption;preference;prevent;Prevention;Process;prototype;Published Comment;Reading;Remote management;remote monitoring;remote patient monitoring;Reporting;Research;research study;Resources;respiratory;Respiratory Disease;Respiratory distress;Respiratory physiology;response;Risk;Risk Factors;Risk Reduction;safety testing;satisfaction;Schedule;sensor;Severities;Shapes;Small Business Technology Transfer Research;Smoke;Speed;success;Symptoms;System;Technology;telehealth;Testing;Time;United States;usability;Visit;wearable device;wearable monitor;wearable sensor technology;Weight;Wildfire;wireless;wireless fidelity;Work

PROJECT_TITLE: A Stand Alone Wearable for Tracking Environmental Exposure and Evaluating Respiratory Response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (11)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health;Women's Health Research

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Women are disproportionally affected by Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) with approximately two-thirds of individuals diagnosed with this condition being women, women being less likely to receive annual blood pressure and weight monitoring, and women more likely to experience delayed initiation of anti-dementia medication than men. The way in which physicians treat female persons with AD/ADRD has important implications on sex and gender disparities in AD/ADRD care quality and outcomes, but the effects of patient-physician gender concordance, physician training diversity, and health system board diversity on sex and gender disparities in AD/ADRD care have not yet been investigated. Using the nationally-representative data with detailed information on patients, physicians, medical schools, residency programs, and health systems, the proposed study will clarify how these physician-level and health system-level factors affect sex and gender disparities in AD/ADRD care, and provide new evidence to develop interventions aimed at eliminating those disparities, such as increasing female representation in physician workforce, introducing sex and gender sensitivity in medical education, and promoting sex and gender diversity in health system boards.

PI_NAMEs: TSUGAWA, YUSUKE  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Admission activity;Affect;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;American Hospital Association;American Medical Association;Association of American Medical Colleges;Blood Pressure;care preference;Caring;Cessation of life;Characteristics;Data;Data Set;Databases;Dementia;dementia care;Depression screen;Development;Diagnosis;Disparity;disparity reduction;Disproportionately impacts women;effective intervention;Elderly;end of life;Environment;evidence base;experience;Exposure to;Faculty;Female;Future;Gender;gender disparity;gender diverse;gender diversity;gender equity;Gender Sensitivity;Goals;Health care facility;health data;Health system;Healthcare;improved;Individual;innovation;Institutional Policy;Interdisciplinary Study;Intervention;Knowledge;Link;Literature;Long-Term Care;male;Medical Education;Medical Residency;medical schools;Medicare claim;men;Methods;Modeling;Monitor;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Physicians;Policies;Policy Maker;Positioning Attribute;Primary Care Physician;Process;programs;Quality of Care;Quasi-experiment;Research;Research Personnel;Residencies;Sampling;Schools;sex;sex disparity;Site;Students;Surveys;Testing;Training;Variant;Weight;Woman;women faculty;women patients;Women's Health;women's treatment

PROJECT_TITLE: The Impact of physician and health system factors on the quality of care for persons with Alzheimer's disease and related dementias at the end of life

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Neurosciences;Rehabilitation

ORG_CITY: FORT WORTH

ORG_NAME: TEXAS CHRISTIAN UNIVERSITY

PHR: PROJECT NARRATIVE Contemporary treatments for hyperfunctional voice disorders such as muscle tension dysphonia (MTD) are effective but typically do not restore voice handicap or voice function to normal thresholds. Recent reports of vibration as a voice therapy modality have been published, but many questions remain about the efficacy of this tool. The current project addresses these problems through a blinded and randomized controlled trial to investigate the efficacy of local translaryngeal vibration for MTD and the dose-response relationship of this modality when compared to treatment without vibration.

PI_NAMEs: WATTS, CHRISTOPHER R. (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Activities of Daily Living;Address;Aftercare;Behavioral;Blinded;Clinical;clinical application;clinical efficacy;clinical practice;Clinical Research;Communication;cost;Diagnosis;disability;Disease;Dose;Dysphonia;effective intervention;effective therapy;efficacy evaluation;Etiology;evidence base;expectation;experience;Financial Hardship;flexibility;Frequencies;Goals;health care service;improved;Income;Individual;innovation;insurance claims;Investigation;Language;Lesion;longitudinal design;Loudness;Measures;Meta-Analysis;Modality;Muscle Tension;Normal Range;novel;Outcome;Outcome Measure;Pathologist;Patients;Phonation;Physiology;placebo group;Population;Prevalence;Public Health;Publishing;Quality of life;randomized, clinical trials;Randomized, Controlled Trials;Rehabilitation Outcome;Rehabilitation therapy;Reporting;Research;Research Design;Research Personnel;Research Project Grants;research study;response;Science;Sensory Receptors;Societies;Speech;Speech-Language Pathology;Stretch Receptors;Stretching;Students;Surface;tool;treatment comparison;treatment effect;Treatment Effectiveness;Treatment outcome;vibration;vocalization;Voice;Voice Disorders;Voice Quality;voice therapy;Work

PROJECT_TITLE: Translaryngeal Vibration for Hyperfunctional Voice Disorders


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: LOGAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PHR: Project Narrative Chronic hepatitis B virus (HBV) infection affects more than 296 million people globally and approximately 820,000 people die each year from HBV infection and related complications such as cirrhosis and hepatocellular carcinoma (HCC). One of the major impediments in developing a cure for HBV is the lack of immunocompetent animal models permissive to HBV infection. The goal of this project is to develop a novel hamster model to support the development of new therapies to cure HBV infection.

PI_NAMEs: GUO, HAITAO ;WANG, ZHONGDE  (contact)

PROJECT_TERMS: Acute;Acute Hepatitis;acute infection;Address;Adenovirus Infections;Adenovirus Vector;Adenoviruses;Affect;Age;Amino Acids;Animal Model;anti-hepatitis B;Anti-viral Agents;Bite;Cells;Cessation of life;Child;Cholesterol Esters;Cholesterol Homeostasis;Chronic;Chronic Hepatitis B;chronic infection;Circadian Rhythm Disorder;Circular DNA;Cirrhosis;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;cost;cytokine;Development;DNA amplification;DNA biosynthesis;Economic Burden;efficacy evaluation;Epigenetic Process;experience;Failure;Gene Modified;Gene Proteins;gene-editing approach;Genes;Genetic;Genetic Engineering;genetic manipulation;Genetic Transcription;genome editing;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Hamsters;HBV Animal Model;Hepatitis B Infection;Hepatitis B Therapy;Hepatitis B Vaccines;Hepatitis B Virus;Hepatocyte;Human;human disease;human model;IL7 gene;Immune response;Immunocompetent;Immunologics;In Vitro;Infection;Integration Host Factors;Interleukin-12;Interleukin-2;Laboratories;Laboratory Animals;Lead;Life Cycle Stages;lipid metabolism;Malignant Neoplasms;Mediating;Mesocricetus auratus;Metabolic syndrome;model organism;Modeling;Mus;Na(+)-taurocholate-cotransporting peptide;Natural Immunity;NOR Mouse;novel;novel therapeutics;Orthologous Gene;Pathogenesis;Pathway interactions;Peptides;permissiveness;Persons;Pharmaceutical Preparations;Physiological;Population;Predisposition;Primary carcinoma of the liver cells;Prophylactic treatment;Proteins;Public Health;Rattus;receptor;Recycling;reproductive;Research;response;Rodent;Role;Taurocholate Sodium;Techniques;Tenofovir;Testing;TNF gene;Transgenic Mice;Tropism;Viral;Virus;Virus Diseases;Virus Inhibitors;Virus Replication

PROJECT_TITLE: Development of a hamster model for hepatitis B virus infection


ADMINISTERING_IC: OH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: New Bedford

ORG_NAME: FISHING PARTNERSHIP HEALTH PLAN

ORG_STATE: MA

PHR: Project Narrative A NIOSH grant renewal will enable Fishing Partnership Support Services (FPSS) to enhance and expand safety training for Mid-Atlantic commercial fishermen, including immigrant workers and those new to fishing, with the goal of reducing the rates of injuries and death resulting from fishing vessel disasters and other dangers. FPSS will offer 18 training sessions in the hands-on courses of Safety & Survival Training and Drill Conductor Certification. FPSS will also promote a culture of safety across the commercial fishing industry by training new safety instructors; by reaching out to fishermen in remote locations and offering safety training within their communities; and by promoting outreach and communication between fishermen themselves about the potentially life-saving impact of safety training.

PI_NAMEs: BARTLETT, JOHN  (contact)

PROGRAM_OFFICER_NAME: GARRETT, BRIDGETTE E

PROJECT_TITLE: Community-Based Safety Training for the Mid-Atlantic Fishing Industry

STUDY_SECTION_NAME: Special Emphasis Panel[ZOH1 DH (02)]


PHR: Project Narrative A NIOSH grant will enable Fishing Partnership Support Services (FPSS) to continue to enhance and expand safety training for New England commercial fishermen, including immigrant workers and those new to fishing, with the goal of reducing the rates of injuries and death resulting from fishing vessel disasters and other dangers. FPSS will offer 30 training sessions where fishermen will complete hands-on courses including Safety & Survival Training, and Drill Conductor Training and Certification. FPSS will also promote a culture of safety across the commercial fishing industry by training new safety instructors; by reaching out to fishermen in remote locations and offering safety training within their communities; and by promoting outreach and communication between fishermen themselves about the potentially life-saving impact of safety training.

PROJECT_TITLE: Community-Based Safety Training for the New England Fishing Industry


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Project Narrative Few treatments target core features of suicidal thoughts and behaviors in Veterans. In the proposed SPiRE study we will determine the acceptability and feasibility of using real-time functional magnetic resonance imaging neurofeedback for reducing suicide-specific rumination, defined as a “repetitive mental fixation on one's suicidal thoughts and intentions” in a transdiagnostic sample of Veterans at elevated risk of suicide. Veterans will learn strategies for modulating activity within brain regions comprising the default mode network, which has been demonstrated to contribute to the maintenance of rumination, as they receive feedback signals from the brain. These data will be used to guide a future randomized double-blind, placebo-controlled study to test the efficacy of real-time functional magnetic resonance imaging neurofeedback as a first-line treatment intervention for reducing suicide-specific rumination in Veterans.

PI_NAMEs: SZESZKO, PHILIP R (contact)

PROJECT_TERMS: acceptability and feasibility;Adult;Aftercare;age difference;Attenuated;Autobiography;Award;Brain;Brain imaging;Brain region;Client satisfaction;Clinical;Clinical assessments;clinical care;cognitive reappraisal;Communities;Data;Daydreams;Diagnostic;disability;Disability scale;Double-Blind Method;efficacy evaluation;efficacy testing;experience;Feasibility Studies;Feedback;Feeling suicidal;follow-up;frontal lobe;Functional impairment;functional independence;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Health;imaging study;improved;insight;Interruption;Intervention;Learning;Magnetic Resonance Imaging;Maintenance;Measures;Medial;Mental Health Services;Meta-Analysis;Methods;military veteran;Mind;Mission;neural circuit;Neurobiology;neurofeedback;Patient Self-Report;personalized strategies;Pharmaceutical Preparations;placebo controlled study;Play;Prefrontal Cortex;Psyche structure;Psychologist;Publishing;Quality of life;Questionnaires;Randomized;Recording of previous events;reducing suicide;Reporting;Research;Rest;Risk Factors;Role;rumination;sample fixation;Sampling;satisfaction;Severities;Sex Differences;Signal Transduction;Social Adjustment;Stimulus;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Testing;Thinking;Time;Veterans;Work;World Health Organization

PROJECT_TITLE: Reducing Suicide-Specific Rumination in Veterans using Real-time Functional Magnetic Resonance Imaging Neurofeedback

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]