ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: ONTARIO INSTITUTE FOR CANCER RESEARCH

ORG_STATE: ON

ORG_ZIPCODE: M5G 0A3

PHR: Project Narrative Reactome is the most comprehensive open-source, open access, manually authored and peer-reviewed pathway knowledgebase. The Reactome knowledgebase and its website enable researchers, clinicians, students, and educators to find, organize, and utilize biological pathway information to support data visualization, analysis and integration.

PI_NAMEs: DEUSTACHIO, PETER G;HERMJAKOB, HENNING ;STEIN, LINCOLN D. (contact);WU, GUANMING

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Adoption;Biological;Biological Process;biological research;cell type;Clinical Research;Code;Collaborations;Communities;computerized tools;computing resources;Controlled Vocabulary;Data;Data Analyses;data modeling;Data Science;Data Scientist;data visualization;Databases;Dedications;Development;Disease;Disease Pathway;Doctor of Philosophy;drug discovery;Ensure;experience;Feedback;Funding;gene product;Genes;Genetic Variation;Genomics;graph database;Growth;Human;improved;Infection;Infrastructure;interoperability;Knowledge Discovery;knowledge graph;knowledgebase;Lead;Literature;Machine Learning;Malignant Neoplasms;Manuals;member;migration;Mining;Modeling;Molecular;novel strategies;Ontology;open data;open source;outreach;Pathologic Processes;Pathway Analysis;Pathway interactions;Peer Review;Pharmaceutical Preparations;Physiological Processes;predictive modeling;Process;protein function;Proteins;Proteomics;Publications;Reaction;Readability;repository;Research;Research Personnel;Resources;Scientist;screening;Software Tools;Students;System;Technology;Tissues;tool;Translational Research;United States National Institutes of Health;Update;Visualization software;web platform;web site;Work

PROJECT_TITLE: Reactome: An Open Knowledgebase of Human Pathways.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)R]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Through intensive mentoring in a highly interactive and collaborative research environment, this T32 program will support the development of outstanding MD, MD/PhD and PhD investigators whose research focus is on rheumatic and autoimmune disease pathogenesis, prevention and treatment. This program has demonstrated substantial success in supporting predoctoral trainees and postdoctoral fellows who are currently in academic positions or evolving academic tracks. Based on positive outcomes in the current funding cycle, we propose to continue to include trainees at both of these key earlier career development periods, as well as short term medical students who are highly motivated to develop research skills and insights into disease.

PI_NAMEs: KUHN, KRISTINE A. (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Research Training;Rheumatology

PROJECT_TITLE: Research Training in Rheumatology


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative The main objective of this R50 proposal is to seek support for a Research Specialist Dr. Youngho Kwon to apply his class-leading expertise to enhance the productivity and impact of a long-standing NCI-funded research program at University of Texas Health San Antonio, and to enable Dr. Kwon to achieve higher autonomy and further career growth. Our NCI-funded program is aimed at deciphering the mechanistic underpinnings of DNA break repair and DNA replication fork preservation via the homologous recombination (HR) pathway that is mediated by several tumor suppressors, including BRCA1-BARD1 and BRCA2. The continual involvement and leadership of Dr. Kwon will exert a broader impact in DNA repair studies and the cancer biology field at the national level, and will also furnish the intellectual and experimental framework for the development of cancer therapeutics.

PI_NAMEs: KWON, YOUNGHO  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Award;BARD1 gene;Biochemical;Biological Assay;Biology;biophysical analysis;BRCA1 gene;BRCA2 gene;Cancer Biology;career;Cells;Chemicals;Chromosome abnormality;Companions;Development;DNA;DNA biosynthesis;DNA Double Strand Break;DNA lesion;DNA Repair;DNA replication fork;doctoral student;Double Strand Break Repair;Extramural Activities;Filament;Funding;Gene Mutation;Genome;Genomic Instability;graduate student;Growth;Health;homologous recombination;insight;Invaded;Investigation;Laboratories;Lead;Leadership;Maintenance;Malignant Neoplasms;Mediating;Mentors;mid-career faculty;Neoplastic Cell Transformation;novel;Pathway interactions;Play;Positioning Attribute;Postdoctoral Fellow;preservation;presynaptic;Process;Productivity;programs;reconstitution;repaired;Research;Role;small molecule;Specialist;structural biology;symposium;System;Texas;Therapeutic;tool;Training;Tumor Suppressor Proteins;tumorigenesis;Universities;Wages

PROJECT_TITLE: BRCA-dependent Mechanisms of Genome Maintenance and Repair


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision

ORG_CITY: BOSTON

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

ORG_STATE: MA

PHR: Narrative Ensuring safety of drivers and other road users is a major public health issue. Intersections are dangerous and fatal accidents occur when drivers fail to see another vehicle or road user. We will evaluate a novel approach to training to assist drivers with vision impairment in looking for potential hazards at intersections with the overall goal of reducing their collision risk.

PI_NAMEs: BOWERS, ALEXANDRA RAE (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Accidents;Address;Age;Area;Automobile Driving;Behavior;blind;Computer Vision Systems;Controlled Environment;Cues;Dangerousness;Data;design;Detection;driving behavior;driving safety;Early Diagnosis;efficacy evaluation;Ensure;Evaluation;Eye;Eye Movements;Failure;Goals;Grant;hazard;Head;Head Movements;Hemianopsia;high risk;improved;laboratory experience;Methodology;Methods;Monitor;novel;novel strategies;Outcome Measure;Patients;Peripheral;Persons;primary outcome;programs;Proxy;Psychological Transfer;Public Health;Quality of life;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Records;Rehabilitation therapy;Research;Research Personnel;response;Risk;Risk Behaviors;Role;Safety;Scanning;Side;Stroke;System;Testing;Time;tool;Training;Traumatic Brain Injury;Video Recording;virtual environment;Vision;Visual;Visual Fields;Visual impairment;Walking;Width

PROJECT_TITLE: Scanning and Detection at Intersections


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: ECOG-ACRIN MEDICAL RESEARCH FOUNDATION

ORG_STATE: PA

PHR: PROJECT NARRATIVE Clinical trials (CT) participation by underrepresented populations continues to fall short, and the multitude of structural, clinical, physician, and patient barriers call for multilevel interventions to enhance referral and enrollment of Black and Latino patients to National Cancer Institute (NCI)-supported CTs. Building on the extensive resources of the ECOG-ACRIN Cancer Research Group (EA) and our team’s expertise in patient navigation research, community engagement, racial/ethnic minority clinical trials enrollment, and implementation science, we will develop a multilevel EA SUPPORT intervention (consisting of a CT Research Literacy Tool and CT Resource Navigators) to increase referral and enrollment of Black and Latino cancer patients to NCI- supported CTs.

PI_NAMEs: PARK, ELYSE R.;SIMON, MELISSA A. (contact)

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TERMS: Address;Advocate;American College of Radiology Imaging Network;anti-cancer research;Awareness;base;Black Populations;Black race;cancer care;cancer clinical trial;Cancer Control;cancer heterogeneity;Cancer Patient;cancer prevention;care delivery;Chicago;Clinical;Clinical Research;clinical research site;clinical trial enrollment;Clinical Trials;Communities;Community Clinical Oncology Program;community engagement;community partners;Data;design;diversity and inclusion;Eastern Cooperative Oncology Group;effectiveness evaluation;effectiveness/implementation trial;Enrollment;Equity;ethnic minority;Ethnic Population;Evaluation;experience;forging;Head and Neck Cancer;Health;health disparity;health equity;health inequalities;Healthcare;Hematologic Neoplasms;Hispanic;Hybrids;implementation determinants;implementation evaluation;implementation science;improved;Infrastructure;innovation;insight;Intervention;Knowledge;Latino;Latino Population;leukemia;Libraries;Link;literacy;Malignant neoplasm of thorax;Malignant Neoplasms;Medical;Medicine;member;minority communities;Minority Groups;minority patient;Multiple Myeloma;National Cancer Institute;novel;Oncologist;Oncology;Outcome;Output;parity;Participant;participant enrollment;patient navigation;patient oriented;patient-level barriers;Patients;Phase;Physicians;Population;Population Heterogeneity;precision medicine;primary care clinician;primary outcome;Process;Provider;racial minority;Randomized;recruit;Research;Research Personnel;Resources;secondary outcome;Site;social health determinants;success;support tools;Testing;Therapeutic Trials;Thinking;tool;Training;Translations;Underrepresented Populations;Urogenital Cancer;virtual;Work

PROJECT_TITLE: The ECOG-ACRIN SUPPORT Trial: Multilevel Intervention to Improve Diverse Enrollment in Cancer Clinical Trials


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE This application will identify an elusive metabolic mechanism centrally governing the function of myeloid-derived suppressor cells (MDSC) in tumors, which could significantly increase the efficacy of promising approaches for cancer immunotherapy. Specifically, information gathered from this effort is expected to: 1) provide insights into the metabolic signals underlying the tolerogenic polarization and reprogramming of MDSC in tumors; 2) set the foundation for the development of novel strategies to functionally reprogram immunosuppressive myelopoiesis in cancer; and 3) enhance the effectiveness of major anti-cancer treatments by transforming “cold” tumors into “hot” malignancies highly infiltrated by reactive T cells and reprogrammed immunogenic myeloid cells that promote sustained anti-tumor activities.

PI_NAMEs: RODRIGUEZ, PAULO CESAR (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Ablation;anti-cancer treatment;Automobile Driving;Beds;Bile Acids;cancer immunotherapy;Cell Physiology;Cell Reprogramming;cell transformation;Cells;checkpoint therapy;Cholesterol;Cholesterol Homeostasis;Chronic;Development;Effectiveness;Endoplasmic Reticulum;endoplasmic reticulum stress;Foundations;Goals;gut inflammation;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune Evasion;Immunity;immunogenic;Immunosuppression;Immunotherapy;In Situ;in vivo;Individual;Infiltration;information gathering;insight;Interferons;Intestines;Knockout Mice;Link;Liver;Liver Regeneration;LoxP-flanked allele;Malignant Neoplasms;Mediating;Mediator;Metabolic;Modeling;Mus;Myeloid Cells;Myeloid-derived suppressor cells;Myelopoiesis;novel strategies;novel therapeutic intervention;Phosphotransferases;programs;protein folding;Proteins;Publications;Reaction;receptor;Receptor Activation;Receptor Signaling;Regulation;response;Role;Signal Transduction;STAT1 gene;success;synergism;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutically effective;transcription factor;Transplantation;tumor;tumor growth;Tumor Immunity;Tumor Markers;tumor microenvironment;type I interferon receptor;uptake;XBP1 gene

PROJECT_TITLE: Bile acids restrict functional reprogramming of myeloid-derived suppressor cells in tumor beds

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Lung;Rare Diseases;Sepsis

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Acute respiratory distress syndrome (ARDS) is a severe form of lung injury. Epidemiologic studies suggest that exposure to the ubiquitous urban air pollutant, ozone, exacerbates ARDS. Our animal and human studies are focused on elucidating inflammatory mechanisms underlying the potentiating effects of ozone on ARDS, which is key to development of new strategies aimed at preventing the development of this disease.

PI_NAMEs: RADBEL, JARED M. (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Affect;Air Pollutants;Animals;Anti-Inflammatory Agents;Apoptotic;Blood;career;Clinical;Cohort Studies;Collectins;Development;Disease;Endotoxemia;epidemiology study;Experimental Models;experimental study;Exposure to;Flow Cytometry;Genes;Genetic;Goals;Grant;Human;Human Pathology;human subject;Impairment;Individual;Inflammation;Inflammatory;Inhalation;insight;Intravenous;Knockout Mice;Link;Lipopolysaccharides;Lung;lung injury;Macrophage;Measures;Mentorship;Modeling;mortality;Mus;neutrophil;Neutrophilia;novel;Oxidants;Oxidative Stress;Oxidative Stress Induction;Ozone;ozone exposure;Pathway interactions;Patients;Predisposition;prevent;Process;Production;Pulmonary Inflammation;Pulmonary Surfactant-Associated Protein D;Reporting;Resolution;Risk;Risk Factors;Role;role model;Sepsis;Single Nucleotide Polymorphism;Stress;Structure;Systemic infection;Testing;Toxic effect;Toxin;transcriptome sequencing;Translational Research;United States Environmental Protection Agency;United States National Institutes of Health;Variant

PROJECT_TITLE: Role of Macrophage Efferocytosis in Ozone-Induced ARDS


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes;Gene Therapy;Genetics;Nanotechnology;Regenerative Medicine;Wound Healing and Care

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Diabetic ulcers are non-healing wounds that pose significant challenges to many patients by decreasing quality of life, increasing mortality, and raising healthcare costs, yet current treatments do not enable ulcer closure or prevent ulcer recurrence in most patients. The proposed project will engineer local, timed delivery of combinations of therapeutics in order to alter the wound environment and promote the healing of ulcers. This research could improve clinical outcomes for patients with diabetic ulcers and provide broader insights into delivering therapies at specific time scales, improving treatments for other diseases of impaired tissue regeneration where timing delivery of the therapy is critical to its effectiveness.

PI_NAMEs: BERGER, ADAM G (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Adsorption;Amputation;angiogenesis;Angiogenesis Inhibitors;Angiogenic Proteins;Antibiotics;Bandage;Biocompatible Materials;Biological;Biological Assay;Blood Vessels;Charge;Chronic;chronic ulcer;chronic wound;Clinical;Code;Complications of Diabetes Mellitus;controlled release;Cues;cytokine;Death Rate;decubitus ulcer;Deposition;Dermal;Diabetes Mellitus;diabetic ulcer;diabetic wound healing;Disease;Dose;Drug Delivery Systems;effective therapy;Effectiveness;efficacy testing;Electrostatics;Endosomes;Endothelial Cells;Engineering;Excipients;Gene Expression;gene function;Genes;healing;Health Care Costs;Histology;Human;immune activation;Impaired healing;Impaired wound healing;Impairment;improved;In Vitro;in vitro Assay;in vivo;Inflammation;Inflammatory;inhibitor;insight;Investigation;Ischemia;Kinetics;Knowledge;Lead;lipid nanoparticle;Macrophage Activation;Malignant Neoplasms;Measures;Mediating;Medicare;Mesentery;Messenger RNA;MicroRNAs;Modeling;Molecular;Molecular Analysis;Molecular Weight;mortality;mortality risk;Mus;Myocardial Infarction;Natural regeneration;Neuropathy;non-healing wounds;nuclease;nucleic acid delivery;nucleic acid-based therapeutics;Nucleic Acids;Nutrient;overexpression;Oxygen;Pathway interactions;Patient-Focused Outcomes;Patients;perfusion imaging;Pharmaceutical Preparations;Phase;Polymers;prevent;Process;Procollagen-Proline Dioxygenase;Quality of life;Recurrence;Regulation;Research;response;RNA;RNA-targeting therapy;self assembly;Signal Pathway;Signaling Molecule;Small Interfering RNA;synergism;System;targeted treatment;Techniques;Therapeutic;Time;tissue regeneration;Tissues;TNF gene;tool;Transfection;Translating;Treatment Efficacy;Ulcer;Untranslated RNA;uptake;Varicose Ulcer;Vascular Endothelial Growth Factors;Work;wound;wound care;wound closure;wound environment;wound healing;Wound models

PROJECT_TITLE: Controlled release of RNA-targeting therapy to promote healing of diabetic ulcers


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Natural Products

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative: Natural product biosynethtic pathways make complex, synthetically challenging molecules that inhibit high value therapeutic targets. Here we are using a newly discovered classes of enzymes from natural product pathways to make new therapeutic scaffolds. These studies will provide new chemoenzymatic methods for preparation of complex, natural product-like macrocycles and new insights into means of inhibiting cancer by targeting challenging protein interfaces.

PI_NAMEs: BOWERS, ALBERT A (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Anabolism;Area;Binding;Biological Assay;Chemicals;Complex;Coupled;Development;Enzymes;Evolution;Goals;inhibitor;insight;Libraries;Ligands;Malignant Neoplasms;Messenger RNA;Methods;Modification;natural product inspired;Natural Products;Natural Products Chemistry;Nature;novel;novel therapeutics;Pathway interactions;Peptide Library;peptide natural products;Peptides;Preparation;Proteins;Ribosomes;scaffold;technology development;Therapeutic;therapeutic target;transcription factor;Work

PROJECT_TITLE: Chemoenzymatic Synthesis, Mode of Action and Evolution of Natural Product-based Macrocycles


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative Genome-wide association studies (GWAS), an approach in which the genomes of both diseased and healthy individuals are scanned to identify genetic variants affecting disease risk, have been broadly successful in identifying genetic variants associated to common disease risk in European populations, leading to successes in predicting disease risk in European populations using polygenic risk scores. Unfortunately, there is a large gap in the accuracy of polygenic risk scores between European and non-European populations, such that clinical efforts to improve biomedical outcomes via precision medicine may exacerbate health disparities. This proposal will improve the accuracy of polygenic risk prediction in non-European populations, thus aiding clinical efforts to improve biomedical outcomes in diverse and underrepresented populations.

PI_NAMEs: PRICE, ALKES L (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Affect;African American;African American population;causal variant;Clinical;Collaborations;Communities;Complex;Computer software;Data;data integration;Data Set;Disease;disorder risk;East Asian;Educational Status;Electronic Health Record;Ethnic Origin;Ethnic Population;European;European ancestry;functional genomics;Gene Expression;Gene Frequency;genetic analysis;genetic architecture;genetic variant;Genome;genome wide association study;genome-wide;genomic data;Genotype;health disparity;improved;Individual;Latino;Latino Population;Letters;Linkage Disequilibrium;Maps;Mediating;Mental disorders;Methodology;Methods;Minor;Molecular;multi-ethnic;Outcome;Pattern;Phenotype;phenotypic data;polygenic risk score;Population;Population Heterogeneity;portability;precision medicine;programs;Publications;Quantitative Trait Loci;Research;Residual state;risk prediction;Sample Size;Sampling;Sampling Studies;Scanning;South Asian;Statistical Methods;statistics;Structure;success;training data;trait;Underrepresented Populations;Variant

PROJECT_TITLE: Leveraging functional data to predict disease risk in multi-ethnic populations

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: AT

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE FOR THE OVERALL U54 CENTER The mission of our Center of Excellence for Natural Product Drug Interaction Research is to provide leadership and guidance on how best to study potential adverse interactions between natural products and conventional medications. Our cross-disciplinary team of experts in clinical pharmacology, natural products chemistry, and health information management and communication will partner with NCCIH officials to select and characterize three to five high priority natural products with the potential to alter drug disposition and lead to suboptimal therapeutic outcomes. A series of carefully designed studies will be executed to assess the drug interaction potential of the selected priority natural products, the major findings of which will be disseminated through our publicly accessible database and at scientific and other relevant meetings to educate researchers and maximize public health benefit.

PI_NAMEs: PAINE, MARY F (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Address;archived data;Archives;Biological;Biological Markers;biomedical informatics;Charge;Chemicals;Clinical;Clinical Pharmacology;clinically relevant;clinically significant;Collaborations;Communication;Communities;cost;Data;Data Analyses;data repository;design;Discipline;Documentation;drug disposition;Drug Interactions;Drug Kinetics;Educational workshop;Elderly;Ensure;experience;Fostering;Goals;Growth;Health;Health Benefit;health communication;Human;improved;In Vitro;Individual;Informatics;Information Management;Infrastructure;innovation;interest;International;Investigation;Journals;Knowledge;Leadership;liquid chromatography mass spectrometry;Manuscripts;Marketing;meetings;Methods;Mission;Modeling;models and simulation;Natural Product Drug;Natural Products;Natural Products Chemistry;Online Systems;outreach;Pharmaceutical Preparations;pharmacokinetic model;Pharmacology;Physiological;Population Heterogeneity;Procedures;Process;public database;Public Health;Publishing;Qualifying;Records;repository;Reproducibility;Research;Research Design;Research Personnel;Risk;Risk Assessment;Safety;Sales;Sampling;Science;Series;Source;Specimen;success;symposium;therapy outcome;Thinking;Time;tool;Update;Vulnerable Populations;web portal

PROJECT_TITLE: Natural Product-Drug Interaction Research: The Roadmap to Best Practices


NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products;Patient Safety

PROJECT_TERMS: Address;Budgets;Cannabis;Clinical;clinically significant;cohesion;Collaborations;Communication;Communities;cost effective;Data;data repository;Decision Making;design;Discipline;dissemination strategy;Drug Interactions;Drug Kinetics;Educational workshop;Ensure;Evaluation;Goldenseal;Green tea;Human;improved;In Vitro;Informatics;innovation;Institution;inter-institutional;International;Leadership;meetings;member;Methodology;Methods;Mission;Mitragyna;Monitor;National Center for Complementary and Integrative Health;Natural Product Drug;Natural Products;Natural Selections;new technology;Outcome;outreach;Pharmaceutical Preparations;Pharmacology;Productivity;programs;Public Health;Publications;Recommendation;Research;Research Personnel;Role;Running;Safety;Sampling;Source;Structure;success;Support System;symposium;Testing;Thinness;Time;Translating;Translations;United States National Institutes of Health;Update;Visit;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Natural Products;Nutrition;Patient Safety

PROJECT_TERMS: Adopted;Adult;aging population;bench to bedside;Biological Markers;Black Pepper;Botanicals;Cannabinoids;Carrier Proteins;Cinnamon - dietary;Clinical;Clinical assessments;Clinical Research;clinically relevant;clinically significant;Collaborations;Companions;Data;Data Analyses;data dissemination;data repository;design;Disease;drug disposition;Drug Interactions;Drug Kinetics;drug metabolism;Drug Prescriptions;Drug Transport;Echinacea purpurea;Elderly;Ensure;Enzymes;Evaluation;experience;Funding;Future;Goals;Goldenseal;Grant;Green tea;gut microbiota;Health Benefit;healthy volunteer;Hemp;Human;In Vitro;in vivo;Informatics;inhibitor;innovation;Kinetics;Leadership;Learning;Licorice;Marketing;Methodology;Methods;Mitragyna;Modeling;models and simulation;Natural Product Drug;Natural Products;Natural Selections;novel;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetic model;Pharmacology;Physiological;Population;Procedures;Process;Public Health;Publications;Recommendation;recruit;Research;research clinical testing;Research Methodology;Research Personnel;response;Risk;risk selection;Sales;side effect;Source;success;synergism;System;therapy outcome;tool;Toxicology;United States Food and Drug Administration;vigilance;volunteer;Vulnerable Populations;web site;Work

PROJECT_TITLE: Pharmacology Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: NEW YORK

ORG_DEPT: ORTHOPEDICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE The proposed research is relevant to public health because it could improve treatment and reduce disability for millions of people who suffer from hand and arm paralysis due to spinal cord injury, stroke, and other diseases affecting movement. The project is relevant to the NIH’s mission because it will help us to better understand how paired brain and spinal cord stimulation can be used to strengthen neural connections, and this knowledge could be used to implement better treatment protocols.

PI_NAMEs: CARMEL, JASON BRANT (contact);HAREL, NOAM Y.;VIRK, MICHAEL S

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Affect;Anatomy;arm;arm function;awake;Behavioral;Brain;Cephalic;Cervical;Cervical spinal cord injury;Cervical spinal cord structure;Chronic;Clinical;comparison control;Data;dexterity;Diameter;disability;Disease;efficacy trial;Electric Stimulation;Electrodes;Engineering;Evoked Potentials;experience;experimental study;Fingers;Forelimb;Goals;Hand;Hand functions;head-to-head comparison;Hour;Human;Hyperreflexia;Hyporeflexia;improved;Individual;Injury;Interruption;Joints;Knowledge;Learning;Magnetic Resonance Imaging;Measures;Mediating;Methods;Mission;Motor;Motor Cortex;Motor Evoked Potentials;Motor Pathways;Movement;Muscle;Muscle Tension;Nature;Neck;Nervous System;neural;neural circuit;Neural Pathways;Neurostimulation procedures of spinal cord tissue;Operative Surgical Procedures;paired stimuli;Paralysed;Participant;Patients;Persons;Physiology;Positioning Attribute;preservation;Public Health;Rattus;recruit;Reflex action;Research;Residual state;response;sensorimotor system;Sensory;Spinal;Spinal Cord;Spinal Cord Diseases;spinal cord imaging;Spinal cord injury;spinal nerve posterior root;spinal pathway;spinal reflex;Stimulus;Stroke;System;Techniques;Testing;Time;Training;Transcranial magnetic stimulation;transcutaneous stimulation;Translating;translation to humans;Treatment Protocols;United States National Institutes of Health;Ventral Roots

PROJECT_TITLE: Spinal Cord Associative Plasticity

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Natural Products;Nutrition;Patient Safety

PI_NAMEs: OBERLIES, NICHOLAS H. (contact)

PROJECT_TERMS: absorption;Address;American;Biological Markers;Black Pepper;Botanicals;Caco-2 Cells;Cannabis sativa plant;Chemicals;Cinnamomum;Cinnamon - dietary;Clinical;Clinical Research;clinically relevant;clinically significant;Collaborations;Communities;Complex;Complex Mixtures;Consumption;Data;data repository;design;dietary supplements;dosage;drug disposition;Drug Interactions;Drug Kinetics;Drug Prescriptions;Echinacea Preparation;Echinacea purpurea;Education;Educational workshop;Ensure;Enzymes;experience;Feces;Funding;Genetic;Goals;Goldenseal;Health;Hemp;Human;In Vitro;in vitro Model;Informatics;innovation;Intestinal Absorption;Intestines;Investigation;Leadership;liquid chromatography mass spectrometry;Mass Spectrum Analysis;metabolomics;method development;Methodology;Methods;Mission;Mitragyna;Modeling;Monitor;monolayer;Natural Product Drug;Natural Products;Natural Products Chemistry;Natural Selections;Participant;Peer Review;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Piper nigrum;Plant natural product;Plasma;Preparation;Process;Publications;Publishing;Reporting;Reproducibility;Research;Research Personnel;research study;Safety;Sales;Sampling;Scientist;Services;Source;Structure;symposium;Testing;trend;Urine;Work;Xenobiotics

PROJECT_TITLE: Analytic Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Genetics;Human Genome;Psoriasis;Regenerative Medicine

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative  Epidermal tissue homeostasis is maintained by precise spatial and temporal control of proliferation and differentiation. Disruption of epidermal homeostasis results in a wide range of human diseases including psoriasis, squamous cell carcinoma, basal cell carcinoma, and chronic wounds. The proposed effort seeks to understand the fundamental gene regulatory mechanisms that govern epidermal growth and differentiation, which may yield new insight and targets for the development of future therapies for epithelial disorders.

PI_NAMEs: BAO, XIAOMIN  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Basal cell carcinoma;Binding;C-terminal;Candidate Disease Gene;Cells;Chimeric Proteins;ChIP-seq;chronic wound;Cleavage And Polyadenylation Specificity Factor;Co-Immunoprecipitations;Complex;Coupled;CRISPR interference;Data Set;design;Development;differential expression;Differentiated Gene;Differentiation and Growth;Disease;DNA Polymerase II;dosage;epidermal stem cell;Epidermis;Epithelium;Equilibrium;Future;Gene Expression;Gene Expression Regulation;gene function;gene product;Genes;Genetic Transcription;Genomic Segment;Genomics;Global Change;Goals;Homeostasis;Human;human disease;human tissue;Impairment;Individual;inhibitor;insight;keratinocyte;keratinocyte differentiation;knock-down;Knowledge;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Monitor;Natural regeneration;novel;novel therapeutics;Pathogenesis;Pattern;Phosphorylation;Play;Polyadenylation;Positive Transcriptional Elongation Factor B;premature;Process;Proliferating;Proteins;Proteomics;Psoriasis;recruit;Research;RNA;RNA Interference;Role;scaffold;Serine;Signal Transduction;Site;skin disorder;Squamous cell carcinoma;Testing;Tissue Differentiation;Tissue Model;tissue regeneration;Tissues;Transcription Elongation;Transcription Initiation;Transcription Repressor;transcription termination;Transcriptional Elongation Factors;transcriptome sequencing;Undifferentiated;Work;wound healing

PROJECT_TITLE: Epidermal Gene Regulation by Transcription Elongation and Termination

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Natural Products;Patient Safety

PI_NAMEs: BOYCE, RICHARD DAVID (contact)

PROJECT_TERMS: Adverse event;Animals;Area;candidate identification;Chemicals;Clinical;Clinical assessments;clinical decision support;clinical practice;Clinical Research;clinically significant;cloud based;Collection;Communities;Community Practice;Companions;Consumption;Data;data dissemination;data ecosystem;data format;Data Reporting;data repository;data submission;design;Discipline;Drug Interactions;Drug Kinetics;Educational workshop;Elements;Evaluation;evidence base;experience;FAIR principles;Foundations;Funding;Health Personnel;Human;improved;In Vitro;in vitro Model;Informatics;innovation;insight;Interview;Leadership;Learning;Link;Manuals;Marketing;Metadata;Methods;Modeling;Morphologic artifacts;Natural Product Drug;Natural Products;novel;Patients;Pharmaceutical Preparations;Pharmacology;pharmacovigilance;Poison;Process;Public Health;Publishing;Recommendation;Reporting;repository;Research;Research Design;Research Personnel;Resources;Scientist;Secure;Series;Services;Signal Transduction;Source;symposium;System;systems research;Time;Visualization;web app;web services;web site

PROJECT_TITLE: Informatics Core


ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE: CENTER CORE The Core Grant for Vision Research provides shared resources that are accessible to a group of independently funded investigators to enhance their research capability and productivity and create an environment conducive to collaborative scientific interactions for inter-disciplinary and translational vision science research to advance knowledge of the visual system and its disorders.

PI_NAMEs: SHUKLA, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Animals;Applications Grants;Area;Artificial Intelligence;Biology;Biometry;Blindness;catalyst;Cellular biology;Center Core Grants;Chicago;clinically relevant;Collaborations;Communities;Core Grant;Data Science;diagnostic development;Disease;disease model;Environment;experience;Functional disorder;Funding;Genomics;Goals;Histology;Illinois;Image;Image Analysis;Individual;instrumentation;Knowledge;member;Molecular and Cellular Biology;Molecular Biology;National Eye Institute;novel diagnostics;novel therapeutic intervention;Performance;prevent;Prevention approach;Productivity;programs;Proteomics;Qualifying;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Running;Services;Technical Expertise;Therapeutic;therapeutic development;Universities;Vision research;vision science;Visual System

PROJECT_TITLE: P30 Core Grant for Vision Research


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PROJECT_TERMS: Center Core Grants;Core Grant;Effectiveness;Ensure;Evaluation;Goals;Individual;Infrastructure;Procedures;Research;Research Personnel;Resources;Vision research;vision science


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Data Science;Digestive Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Prevention;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Pancreatic cancer is a major cause of cancer death in the United States, largely due to diagnosis at a late stage in the majority of patients. We will pursue advancements in the critical areas of population-level risk assessment, non-invasive early pancreatic cancer biomarkers, and metastasis prediction through (1) machine learning models for risk assessment from electronic medical record data and imaging studies, (2) validation of biomarkers of metabolic dysfunction caused by early pancreatic tumors, and (3) characterization of imaging features and tissue-specific methylation patterns in circulating cell-free DNA that predict future metastases. Thus, we seek to reduce pancreatic cancer mortality at multiple stages by identifying high-risk individuals in the general population, using non-invasive biomarkers to select individuals who should undergo intensive surveillance, and predicting metastases in those with apparently localized pancreatic cancer.

PI_NAMEs: ROSENTHAL, MICHAEL H.;WOLPIN, BRIAN MATTHEW (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Address;Architecture;Area;Atrophic;automated assessment;biobank;Biological Markers;biomarker identification;biomarker validation;Blood;Blood specimen;cancer biomarkers;Cancer Center;Cancer Detection;Cancer Etiology;cancer recurrence;carcinogenesis;cell free DNA;Cessation of life;chronic pancreatitis;Clinical;Clinical Data;clinical implementation;Collaborations;Communities;Computerized Medical Record;Data;Data Collection;data infrastructure;data modeling;data resource;Data Set;Dedications;Detection;detection test;Development;Diagnosis;Diameter;Disease;Duct (organ) structure;Early Diagnosis;Early identification;early onset;Event;Excision;Exocrine pancreatic insufficiency;experience;Feces;federated learning;Fingerprint;Future;General Population;Genetic;Genetic Risk;Goals;high risk;high risk population;Human;Image;imaging approach;imaging study;Immune response;improved;improved outcome;Incidence;Individual;innovation;Liver;Localized Disease;Location;Machine Learning;machine learning model;machine learning prediction;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Metabolic;Metabolic dysfunction;Metabolism;Metastatic Neoplasm to the Liver;Methylation;methylation pattern;Modeling;mortality;mouse model;Muscular Atrophy;nanosensors;Neoplasm Metastasis;novel strategies;Operative Surgical Procedures;Organ;Pancreas;pancreas development;Pancreatectomy;Pancreatic Cyst;Pancreatic cystic neoplasia;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;patient population;patient subsets;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Performance;Peripheral;Population;Probability;Recurrence;Recurrent disease;Research;Risk;Risk Assessment;risk prediction;risk stratification;Role;sample collection;Sampling;Sampling Studies;screening;Screening for cancer;standard of care;stool sample;structured data;surveillance imaging;Techniques;Technology;Terminology;Testing;Time;Tissues;Translating;tumor;Tumor Tissue;United States;unstructured data;Work;X-Ray Computed Tomography

PROJECT_TITLE: Altered metabolism and machine learning for pancreatic cancer early detection


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Algorithmic Software;Cells;Computer software;Core Grant;Development;Environment;Equipment;Fluorescence;Goals;high resolution imaging;Image;Image Analysis;image processing;imaging software;imaging system;in vivo imaging;innovation;investigator training;Lasers;Light Microscope;live cell imaging;Microscope;Microscopy;Ophthalmoscopy;Optical Coherence Tomography;Productivity;Research;Research Personnel;Scanning;Vision research;vision science

PROJECT_TITLE: Imaging and Image Analysis Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative To fertilize an egg, sperm must undergo a post-ejaculation maturation process and swim long distances. Both processes consume a great deal of energy. In this application, we propose to identify how sperm gain sufficient energy to complete their maturation and reach the egg.

PI_NAMEs: BUCK, JOCHEN  (contact);LEVIN, LONNY R;VISCONTI, PABLO E.

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Acrosome Reaction;Adenylate Cyclase;Adult;Assisted Reproductive Technology;Award;Bicarbonates;Bioenergetics;Body Fluids;Cells;Citric Acid Cycle;Comparative Study;Consumption;Cyclic AMP;Data;egg;Ejaculation;Embryonic Development;Energy-Generating Resources;Environment;Enzymes;Epididymis;Exposure to;Extracellular Fluid;Fatty Acids;female reproductive tract;Fertilization;Fertilization in Vitro;Fructose;Funding;Genetic;Glucose;Glycolysis;Goals;Human;Image;in vitro activity;inorganic phosphate;Label;Mammalian Oviducts;Mediating;meetings;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methodology;Mitochondria;Modernization;Molecular;Motility;Mus;Nutrient;Oocytes;Oxidative Phosphorylation;Pathway interactions;Pattern;Pentosephosphate Pathway;pharmacologic;Physiology;Process;Protein Isoforms;Pyruvate;Regulation;Reproduction;reproductive tract;Resources;response;Second Messenger Systems;Seminal fluid;Signal Pathway;Signal Transduction;Site;Source;Sperm Capacitation;sperm cell;sperm function;stable isotope;Swimming;Testing;tool;Travel;zygote

PROJECT_TITLE: Comparative studies on the regulation of metabolism during sperm capacitation

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Aging;Bioengineering;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Diabetes;Genetics;Human Genome;Immunotherapy;Women's Health Research

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: NARRATIVE The prevalence of co-morbid disorders of metabolism is expanding rapidly among breast cancer patients in U.S cities, particularly at safety net hospitals, where the burden of obesity, hypertension and diabetes can easily affect half of the patient population. Systems biology approaches have not yet been mobilized effectively to understand complex relationships among abnormal metabolism, chronic inflammation and immune exhaustion in the tumor microenvironment of breast cancer in patients with co-morbid metabolic disease. Specifically, there is an acute public health need for tumor infiltrate nucleic acid sequence data to be annotated with metabolic information: integrated -omics, immune exhaustion and metabolic profiles of these patients, such as we will develop, must inform models of breast cancer progression and mortality for these at-risk patients.

PI_NAMEs: DENIS, GERALD V (contact);EMILI, ANDREW ;MONTI, STEFANO

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Acute;Address;Adipose tissue;Affect;Algorithms;American;Apoptotic;Automobile Driving;Base Sequence;Biological Assay;Blocking Antibodies;Breast;Breast Cancer Cell;Breast Cancer Epidemiology;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;Breast Oncology;Bromodomains and extra-terminal domain inhibitor;Cancer Burden;Cancer Model;Cancer Patient;cancer subtypes;CD8B1 gene;cell killing;Cell model;Cells;Cellular Metabolic Process;checkpoint receptors;Chemicals;Chronic;chronic inflammatory disease;Cities;Clinical;clinically relevant;Coculture Techniques;cohort;comorbidity;Complex;Computer Models;Dangerousness;Data;Development;Diabetes Mellitus;Disease;Endocrinology;epidemiologic data;Estrogen receptor negative;exhaust;exhaustion;experience;experimental study;Genes;Goals;Hospitals;Hypertension;Immune;immune cell infiltrate;immune checkpoint;Immunology;Immunooncology;Immunophenotyping;Immunotherapy;improved;Infiltration;Inflammation;Inflammatory;innovation;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mass Spectrum Analysis;mathematical model;Medical Oncology;Metabolic;Metabolic Diseases;metabolic profile;Metabolism;Metformin;Micrometastasis;model building;Modeling;Molecular;mortality;multi-scale modeling;multidisciplinary;multiple omics;neoplasm immunotherapy;Neoplasm Metastasis;neoplastic cell;network models;Newly Diagnosed;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organoids;Outcome;Pathway Analysis;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;phosphoproteomics;polarized cell;Population Sciences;Prediabetes syndrome;Prevalence;Primary Neoplasm;primary outcome;Process;profiles in patients;Prognosis;programs;Prospective Studies;Proteins;Proteome;Proteomics;Public Health;Publishing;Research Personnel;Resolution;response;Risk;safety net;Signal Transduction;single-cell RNA sequencing;Suggestion;Surgical Oncology;System;Systems Biology;T cell receptor repertoire sequencing;T-Lymphocyte;T-Lymphocyte Subsets;Talents;Testing;The Cancer Genome Atlas;transcriptome;transcriptome sequencing;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-infiltrating immune cells;Woman

PROJECT_TITLE: Multiscale analysis of metabolic inflammation as a driver of breast cancer


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: AAKALU, VINAY  (contact)

PROJECT_TERMS: Cell Culture Techniques;Cell Line;Cells;Cellular biology;Cloning;Core Grant;cost;Cultured Cells;design;DNA;DNA sequencing;Equipment;experimental study;Flow Cytometry;Goals;Histologic;Histology;Individual;instrument;instrumentation;laser capture microdissection;MicroRNAs;Molecular Biology;Morphology;Organ Culture Techniques;Protein Analysis;Proteomics;Research;Research Personnel;Services;skills;Specimen;stem cells;Time;Tissues;Transfection;Viral Packaging;Viral Vector;virology;Vision research

PROJECT_TITLE: Cellular and Molecular Biology Core


PI_NAMEs: YAO, XINCHENG  (contact)

PROJECT_TERMS: animal colony;animal facility;Animal Model;Animals;Core Grant;Development;Equipment;Evaluation;Experimental Animal Model;Eye;Eye diseases;Generations;Genotype;Goals;Image;knockin animal;knockout gene;novel therapeutics;Pathologic;Performance;Procedures;Production;Research Personnel;Resources;Services;Structure;Testing;Therapeutic Agents;Tissue Harvesting;Transgenic Organisms;Translational Research;translational scientist;Universities;Vision research

PROJECT_TITLE: Animal Services Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Immunotherapy;Kidney Disease;Organ Transplantation;Transplantation

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE While antibody-mediated lymphocyte depletion is commonly used to eliminate donor-reactive T cells in transplant recipients, its impact on long-term transplant survival remains controversial. The proposed studies will investigate how inflammatory pathways triggered by allograft transplantation drive rapid reconstitution of pathogenic memory T cells. Based on the gained mechanistic insights, we will test several clinically relevant approaches for prolonging heart allograft survival in recipients treated with lymphoablation.

PI_NAMEs: FAIRCHILD, ROBERT L (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Acute;Allogenic;allograft rejection;Allografting;analog;Animal Model;Antibodies;Antibody Response;Antibody titer measurement;antibody-mediated rejection;Antithymoglobulin;Attenuated;B-Cell Activation;B-Lymphocytes;Binding;Biopsy;Blood capillaries;C Type Lectin Receptors;C-Type Lectins;CCR5 gene;CDW52 gene;Cell Compartmentation;Cell Physiology;Cells;Chronic;Clinical;clinically relevant;complement C4d;cytokine;Data;Deposition;Development;Disease;donor-specific antibody;efficacy testing;Endothelial Cells;Endothelium;Equilibrium;Event;experience;experimental study;Fibrin;Fibrosis;Funding;Genetic;Glomerular Capillary;Goals;granulocyte;heart allograft;Histopathology;Immune;Immunosuppression;improved;Incidence;Infiltration;Inflammation;Inflammatory;Injury;insight;Interleukin-1 beta;Interleukin-6;Ischemia;kidney allograft;Kidney Transplantation;Leukocyte Trafficking;Lymphocyte Depletion;Macrophage;Mediating;memory CD4 T lymphocyte;Modeling;molecular marker;Monoclonal Antibodies;monocyte;mouse model;Mus;Myeloid Cells;Natural Killer Cells;nephrogenesis;neutrophil;new therapeutic target;NK Cell Activation;novel;Organ;Oryctolagus cuniculus;Pathogenicity;Pathway interactions;Pattern recognition receptor;Peptide/MHC Complex;Peroxidases;Population;post-transplant;prevent;Production;reconstitution;Recovery;recruit;Regimen;Reperfusion Injury;Reporting;Resistance;Role;sensor;Serum;Signal Transduction;success;T cell reconstitution;T cell response;T memory cell;T-Cell Proliferation;T-Lymphocyte;Testing;Time;Tissue Grafts;tissue injury;TLR4 gene;TNFRSF5 gene;TNFSF5 gene;Transplant Recipients;Transplantation;Tubular formation;virtual

PROJECT_TITLE: Acute Antibody Mediated Kidney Allograft Rejection

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Bioengineering;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MCANANY, JAMES JASON (contact)

PROJECT_TERMS: Acceleration;Artificial Intelligence;Basic Science;bench to bedside;Biological Models;Biology;Biomedical Research;Center Core Grants;Classification;Clinical;Computer software;confocal imaging;Core Grant;Data;Data Analyses;Data Collection;Data Science;Dedications;Diagnosis;Diagnostic;diagnostic development;Disease;Elements;Emerging Technologies;Equipment;Expert Systems;Eye diseases;Floods;Funding;Future;Generations;Goals;Grant;Human Resources;Image;insight;Investigation;Laboratories;laboratory equipment;Laboratory Personnel;Laboratory Procedures;Methods;Modeling;Molecular;novel diagnostics;novel therapeutic intervention;Ophthalmology;Pathway interactions;Pattern;Personal Computers;Phase I Clinical Trials;Prevention;Process;programs;Proteomics;Reproducibility;Research;Research Activity;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Resources;Services;Techniques;Technology;Therapeutic;therapeutic development;tool;transcriptome sequencing;Translating;translation to humans;translational goal;Translational Research;Variant;virtual;Vision research;Visualization

PROJECT_TITLE: Translational Core for Therapeutic and Diagnostic Development


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: While diabetic retinopathy (DR) cases are rising globally, and newer treatments are emerging, there is a lack of biomarkers reflecting retinal vascular health. We propose that the RNA levels (mRNA and miRNA) and inflammation in circulating angiogenic cells (CACs) will serve as a biomarker of DR. We will perform RNA sequencing of CACs in DR patients and study how a change in miRNA levels leads to retinopathy using rodent models.

PI_NAMEs: BHATWADEKAR, ASHAY D (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Animal Model;autocrine;Background Diabetic Retinopathy;Biological Markers;Biological Models;biomarker discovery;Biometry;Blindness;Blood capillaries;Blood Vessels;Bone Marrow;Bone Marrow Cells;candidate marker;CD14 gene;CD34 gene;Cell Physiology;Cells;Chimera organism;Circulation;Clinical;cohort;Data;db/db mouse;Defect;Development;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Diagnosis;diagnostic tool;differential expression;Electroretinography;Endothelial Cells;endothelial repair;Endothelium;Exhibits;feature selection;Flow Cytometry;Foundations;Future;Genomics;Goals;Grant;Health;Healthcare;Human;Impairment;improved;Individual;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Injury;insight;Interleukin-1 beta;ITGA5 gene;Lesion;Longitudinal Studies;Machine Learning;machine learning model;Maps;Messenger RNA;MicroRNAs;migration;Modeling;Mus;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel marker;overexpression;paracrine;Pathologic;Pathology;Patients;Peripheral;Persons;Phenotype;potential biomarker;predictive tools;Prognosis;prognostic algorithm;Proliferating;proliferative diabetic retinopathy;Proto-Oncogene Protein c-kit;repaired;reparative capacity;Reporter;Research;Research Design;Retina;retinal damage;Retinal Diseases;RNA;Rodent;Rodent Model;Role;Sampling;Series;Severities;Solid;standard of care;Surface;System;Systems Biology;Testing;Toll-like receptors;transcriptome sequencing;transcriptomics;Up-Regulation;Validity of Results;Vascular Diseases;vascular injury;Visual impairment

PROJECT_TITLE: miR-92a as a biomarker of diabetic retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative The ability to monitor therapy success during the course of the treatment is incredibly valuable and still a big challenge for the implementation of biomaterials like metal/electrical implants and nanoparticle-based drug delivery. This research will help us understand how develop therapies that are personalized to the patient’s unique macrophage functional signature. This work could lead to the development of better real-time biological sensors which could improve patient outcomes.

PI_NAMEs: WAYNE, ELIZABETH C (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Biocompatible Materials;Bioluminescence;bioluminescence imaging;Biosensor;Cells;Cellular Metabolic Process;Classification;Data;Development;diagnostic development;Diagnostic tests;Disease;Drug Delivery Systems;Environment;extracellular;Genomics;Goals;imaging system;Implant;implementation barriers;improved;Knowledge;Macrophage;Measures;Metals;Microscopy;Monitor;nanoparticle;nanoparticle drug;new therapeutic target;novel strategies;Pathologic Processes;Patient-Focused Outcomes;Patients;personalized medicine;Physiological Processes;polarized cell;programs;protein expression;Proteomics;Research;Solid Neoplasm;stem cell differentiation;Stimulus;success;synthetic biology;System;Technology;therapy development;Time;tool;Work

PROJECT_TITLE: Elucidating spatial and temporal dynamics of macrophage polarization using bioluminescence microscopy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Substance Misuse

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Cirrhosis, which is the end-stage of liver injury can lead to complications and death, but it is difficult to predict which patients are at risk and therefore, to prevent them from happening. As part of this multi-center study, we aim to collect data and samples from hundreds of patients with cirrhosis and follow them over time to better define who is at greater risk for progression. We will also participate in a trial to prevent progression of disease in which a cholesterol- lowering medication, which has positive effects on liver disease, will be compared to placebo in a large group of patients with cirrhosis.

PI_NAMEs: BAJAJ, JASMOHAN S;SANYAL, ARUN J (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Address;adjudication;Alcoholic Liver Diseases;Ancillary Study;Anti-Inflammatory Agents;Ascites;atorvastatin;Automobile Driving;base;Benefits and Risks;Biological Specimen Banks;Biology;Cardiac;Cardiovascular system;Cataloging;Cessation of life;Child;Cholesterol;chronic liver disease;circulating biomarkers;Cirrhosis;Clinical;Clinical Research;Clinical Trials;cohort;Collaborations;Collection;Compensation;Controlled Clinical Trials;Data;data acquisition;Development;Disease;disease model;Disease Progression;Dose;Double-Blind Method;drug withdrawal;efficacy evaluation;Encephalopathies;end stage liver disease;Enrollment;Etiology;Event;experience;Feasibility Studies;Fibrosis;follow-up;Foundations;Future;healthcare burden;Hemorrhage;Hepatic;HIV;Image;improved outcome;Individual;Infrastructure;innovation;insight;Knowledge;Laboratories;Letters;Liver;Liver Cirrhosis;Liver diseases;liver injury;Longitudinal cohort;longitudinal database;Machine Learning;machine learning method;Measurement;Measures;Medical center;meetings;Mission;model development;Modeling;Monitor;Multicenter Studies;Multicenter Trials;National Institute of Diabetes and Digestive and Kidney Diseases;nonalcoholic steatohepatitis;novel;Observational Study;Outcome;Participant;Patients;Pharmaceutical Preparations;Phase;Placebo Control;Placebos;Population;prevent;primary endpoint;Process;programs;progression risk;Property;prospective;Protocols documentation;public-private partnership;Randomized;Recording of previous events;recruit;Reproducibility;Research Infrastructure;response;Risk;Risk Reduction;risk stratification;Risk-Benefit Assessment;Safety;Sample Size;Sampling;secondary analysis;Severities;Special Population;specific biomarkers;Specific qualifier value;Spleen;Technology;Telemedicine;Testing;Therapeutic Studies;Time;tool;Toxic effect;Translational Research;trial design;Varicosity;Viral hepatitis

PROJECT_TITLE: Liver Cirrhosis Network: Clinical Research Centers


NIH_SPENDING_CATS: Biotechnology;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative The proposed research will investigate novel mechanisms of DNA electrotransfer in cells and tissues. Results from the study will lead to development of new strategies for improving electrotransfer mediated delivery of naked DNA for treatment and prevention of diseases.

PI_NAMEs: YUAN, FAN  (contact)

PROJECT_TERMS: Area;Cells;cellular engineering;Chemicals;COVID-19 pandemic;Cultured Cells;Cytoplasm;Development;disorder prevention;DNA;DNA Structure;Electroporation;epigenome editing;experience;extracellular;flexibility;genome editing;improved;In Vitro;in vivo;Interphase Cell;Mediating;Molecular;Molecular Analysis;nanoparticle;novel;novel strategies;Nuclear;Nuclear Localization Signal;Nuclear Pore Complex;Physiologic pulse;Process;Research;screening;success;Techniques;Tissues;transgene expression;Transport Process;Travel;Vaccination;Vesicle;vesicle transport;Work

PROJECT_TITLE: Chemically Assisted Electrotransfer of DNA

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE The project will develop algorithms and software that will enhance the reuse of publicly available RNA-seq data. The resource will enable cancer researchers to form more informed hypotheses about tumor molecular evolution; and this work will lead to the identification of key molecular drivers as potential novel targets for the treatment of various complex human cancers.

PI_NAMEs: MA'AYAN, AVI  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;Algorithms;anti-cancer research;application programming interface;Atlases;Benchmarking;Biological Process;Cancer cell line;Case Study;Cell Line;cell type;Cells;ChIP-seq;Classification;cloud based;Communication;Communities;Companions;Complex;computational pipelines;Computer software;computerized data processing;cost;cost effective;crowdsourcing;Data;Data Analyses;data format;data integration;data mining;data portal;data repository;data reuse;data visualization;deep learning;Development;Disease;Educational workshop;experimental study;FAIR principles;FarGo;file format;Frequencies;Gene Expression;Gene Expression Process;Gene Expression Profile;gene function;Generations;Genes;genome analysis;Goals;graphical user interface;Human;human RNA sequencing;improved;Infrastructure;insertion/deletion mutation;interoperability;Laboratories;Malignant Neoplasms;Manuals;Metadata;Methods;Mining;Molecular;Molecular Evolution;Mutation;Names;Natural Language Processing;neoplastic cell;Normal tissue morphology;novel;Online Systems;open data;Organism;outreach;Pathogen detection;Pathogenicity;Performance;Pharmaceutical Preparations;Phenotype;Process;Publishing;Pythons;Quantitative Trait Loci;Readability;repository;Research Personnel;Resources;Sampling;Services;Single Nucleotide Polymorphism;single-cell RNA sequencing;small molecule;Source;Supervision;Technology;Tissues;Training;Transcript;transcriptome sequencing;transcriptomics;tumor;Tumor Subtype;Tumor Tissue;Untranslated RNA;Update;Variant;virtual;Work

PROJECT_TITLE: ARCHS4: Massive Mining of Publicly Available RNA Sequencing Data


ADMINISTERING_IC: DA

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: PISCATAWAY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: PROJECT NARRATIVE d Opioid use disorder (OUD) frequently co-occurs with posttraumatic stress disorder (PTSD), and there is an imminent need for the development of effective interventions addressing this severe comorbidity. The proposed study will test the preliminary efficacy of combining medications for OUD with an integrated, trauma-focused, behavioral treatment for co-occurring substance use disorders and PTSD while advancing Dr. Saraiya’s goal to become an independent clinical researcher in the field of opioid research. Findings will demonstrate how a combined treatment approach may reduce opioid use and PTSD symptoms, enhance retention on medications for OUD and in behavioral treatment, and decrease public health care costs among a population in dire need.

PI_NAMEs: SARAIYA, TANYA CHANDRESH (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: addiction;Address;Adult;Affect;Aftercare;American;Back;Behavior Therapy;Behavioral;behavioral clinical trial;Biological;career;career development;Chronic;chronic pain;Clinical;clinical care;clinical practice;clinical trial implementation;Clinical Trials;Cognitive Therapy;Combination Medication;Combined Modality Therapy;comorbidity;Complex;Conduct Clinical Trials;craving;Data;design;Development;DSM-V;Ecological momentary assessment;effective intervention;effective therapy;efficacious intervention;Ensure;Evaluation;evidence base;Evidence based treatment;experience;FDA approved;feasibility testing;Feedback;Feeling suicidal;Focus Groups;Future;Goals;Grant;Health Care Costs;Health Expenditures;Helping to End Addiction Long-term;implementation intervention;improved;Individual;innovation;Intervention;intervention effect;Knowledge;knowledge base;longitudinal analysis;Manuscripts;Measures;Medical;medication compliance;medication for opioid use disorder;Mental Depression;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modification;Moods;National Institute of Drug Abuse;open label;Opioid;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;overdose risk;Pain;Participant;patient oriented;Patients;pharmacologic;Pharmacotherapy;physical conditioning;Population;Post-Traumatic Stress Disorders;Process;programs;Provider;psychiatric comorbidity;Public Health;Randomized;randomized, clinical trials;Research;Research Personnel;responsible research conduct;Risk Factors;secondary outcome;service providers;Severities;Site;skill acquisition;skills;Solid;South Carolina;Standardization;Strategic Planning;substance use;Substance Use Disorder;Symptoms;Testing;therapy design;therapy development;Time;time use;Training;Trauma;Treatment Efficacy;Treatment outcome;Treatment Protocols;treatment research;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Integrated Treatment for Co-Occurring Opioid Use Disorder and Posttraumatic Stress Disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Substance Misuse

PHR: Project Narrative The proposed research is relevant to human health because patients with cirrhosis of the liver are at risk of liver disease progression, liver cancers and death, and treatments as well as the ability to identify patients at the highest risk of complications are lacking. In this application to be a clinical center in the Liver Cirrhosis Network, we propose to develop a prospective cohort to identify new ways to determine the risk of disease progression in patients with cirrhosis, and to test whether the medications pravastatin or alirocumab decrease this risk. The execution of these studies collaboratively throughout the Liver Cirrhosis Network will be crucial to understanding how patients with liver disease progress and how we can improve outcomes in this population in need.

PI_NAMEs: BROWN, ROBERT S (contact);VERNA, ELIZABETH CLARICE

PROJECT_TERMS: Alcoholic Liver Diseases;Behavior;Behavioral;Biological Markers;biomarker discovery;Cessation of life;Cholestasis;chronic liver injury;Cirrhosis;Clinical;clinical center;Clinical Data;clinical predictors;Clinical Trials;Clinical Trials Design;clinically relevant;cohort;Cohort Studies;comorbidity;Compensation;Complex;Cryptogenic cirrhosis;Data;Data Set;Development;Disease Progression;disorder risk;Effectiveness;efficacy evaluation;Electronic Health Record;Electronics;endothelial dysfunction;Etiology;Fatty acid glycerol esters;fibrogenesis;Future;Generations;Health;Hepatic;Hepatotoxicity;high risk;Human;improved;improved outcome;Incidence;Individual;Inflammation;inflammatory marker;inhibitor;innovation;insight;Intervention;Intervention Trial;Knowledge;Life;lipid metabolism;Lipids;Lipoproteins;Liver;liver allograft;Liver Cirrhosis;Liver diseases;liver transplantation;Low-Density Lipoproteins;Malignant neoplasm of liver;Measurement;Mediating;Meta-Analysis;Metabolic;Metabolism;microbiome;Morbidity - disease rate;mortality;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutics;Outcome;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase;Phenotype;Placebos;Play;Population;Portal Hypertension;Pravastatin;predictive modeling;prevent;Prevention;Primary carcinoma of the liver cells;Proprotein Convertases;prospective;Prospective cohort;Prospective Studies;Prospective, cohort study;Randomized;Randomized, Controlled Trials;Reporting;Research;Resources;Retrospective Studies;Risk;Risk Factors;Role;Safety;safety study;Serum;Subtilisins;Testing;therapy outcome;Translational Research;United States;Validation;virtual;virtual world

PROJECT_TITLE: Strategies and Therapies for Outcomes Prevention in Cirrhosis: The STOP-C Liver Cirrhosis Network


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE: The public health burden of COPD-related healthcare utilization is high, and low-income individuals contribute significantly with increased frequency of hospitalizations and early readmissions. Incorporating social care into healthcare delivery by addressing disadvantages of social determinants of health and associated stressors that are commonly experienced by low-income populations has become a priority for national agencies, including the Institute of Medicine and the National Academies of Science, Engineering, and Medicine. The project described in this career develop K23 application will use a mixed methods research design to develop and test a theory-driven community health worker-led stress reduction intervention that will focus on reducing psychological stress by addressing social determinants of health, providing COPD disease education, and promoting proactive coping behaviors.

PI_NAMEs: PAREKH, TRISHA M (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;Adult;adverse outcome;Anxiety;Area;behavior influence;Behavioral;biological adaptation to stress;care systems;career;career development;Caring;Cessation of life;Chronic Disease;Chronic Obstructive Pulmonary Disease;Chronic stress;Clinical;Communities;community based research;community engaged research;community engagement;Community Health Aides;Competence;Confidence Intervals;coping;Coping Behavior;cost;Data;Development;Disadvantaged;Disease;Education;Emergency department visit;Engineering;Epidemiology;Exclusion;experience;feasibility testing;Feedback;follow-up;Food;Frequencies;Funding;Future;Genetic;Goals;Grant;Health;Health behavior;health care availability;Health Care Costs;health care delivery;health care service utilization;health determinants;Health Disparities Research;health disparity;Health Insurance;High Prevalence;high risk;hospital readmission;Hospitalization;housing instability;improved;improved outcome;Income;Individual;innovation;insight;Institute of Medicine (U.S.);Intervention;intervention mapping;Interview;Investments;K-Series Research Career Programs;Knowledge;Low income;Low Income Population;low socioeconomic status;marginalized population;Medical;Medicine;Mental Depression;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;Odds Ratio;Outcome;Outcome Measure;patient population;Patients;perceived stress;Physiological;poor health outcome;Poverty;premature;Preparation;primary outcome;Process;programs;prototype;psychologic;Psychological Stress;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Reduce health disparities;research and development;Research Design;Research Methodology;Research Personnel;Research Project Grants;research study;Resources;response;Risk;Risk Factors;secondary outcome;Series;smoking prevalence;Smoking Status;social;social disparities;social health determinants;Social support;Stress;Stress and Coping;stress management;stress reduction;Stressful Event;stressor;Surveys;systemic inflammatory response;Targeted Research;Testing;theories;therapy development;Tobacco use;Training;Training Activity;Transact;Transportation;United States;United States National Academy of Sciences;Work

PROJECT_TITLE: Development of a Community Health Worker-Led Stress Reduction Intervention for Low-Income COPD Patients

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Narrative This project is to optimize and characterize pre-clinical candidates of RET inhibitors in order to develop a next- generation of drug to treat RET-positive cancers, such as metastatic lung and thyroid cancers, that acquire resistance to the existing RET inhibitors. The next-generation of RET inhibitors are needed to increase the duration of tumor response to treatment.

PI_NAMEs: MERIC-BERNSTAM, FUNDA ;SINTIM, HERMAN O;WU, JIE  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: absorption;Affinity;aqueous;Benzamides;Biological Availability;Biological Markers;Bypass;Cancer cell line;Cancer Patient;cancer therapy;Central Nervous System;Central Nervous System Neoplasms;Chronic;Clinical;clinical development;Clinical Research;Collaborations;Data;design;Dose;Dose Limiting;Drug Kinetics;Drug or chemical Tissue Distribution;Drug resistance;Drug Targeting;Engineering;Ethers;Evaluation;Excretory function;Exhibits;Gatekeeping;Genes;Goals;Human;Immune checkpoint inhibitor;In Vitro;in vivo;inhibitor;Intracranial Neoplasms;KDR gene;kinase inhibitor;Laboratory Study;Lead;lead optimization;Lung Neoplasms;Malignant neoplasm of lung;Malignant neoplasm of thyroid;Malignant Neoplasms;Metabolism;Metastatic malignant neoplasm to brain;Modeling;Mus;mutant;Mutation;next generation;Niacinamide;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Oncogenes;Oncogenic;Oral;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacodynamic model;pharmacokinetics and pharmacodynamics;Phosphotransferases;physiologically based pharmacokinetics;pre-clinical;Property;Protein Tyrosine Kinase;Regimen;Resistance;resistance mechanism;response;scaffold;scale up;Solubility;Solvents;Structure-Activity Relationship;subcutaneous;targeted treatment;Therapeutic Index;Toxic effect;Transfection;Transgenic Mice;treatment response;tumor;tumor xenograft;Tumor-Derived;Tyrosine Kinase Inhibitor;United States Food and Drug Administration

PROJECT_TITLE: Discovery of the next-generation RET-targeted drugs based on nicotinamide scaffold

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Justice-involved individuals account for a significant proportion of U.S. suicides each year, and many are not well-connected to community care. Justice and police settings have limited mental health intervention capacity, and health systems are typically not aware of their patients’ justice involvement. The National Center for Health and Justice Integration for Suicide Prevention (NCHATS): (1) uses contact with the justice system (e.g., police contact, court involvement, arrest) as a novel indicator of suicide risk in the general population; (2) demonstrates how big data systems that efficiently track publicly available data on justice involvement can be linked to health system records to identify individuals at risk for suicide and connect them to community care; and (3) examines effectiveness and scalability of suicide prevention approaches using these methods.

PI_NAMEs: AHMEDANI, BRIAN KENNETH;JOHNSON, JENNIFER E (contact);WEINSTOCK, LAUREN M

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: 911 call;Acute;Address;Admission activity;Area;Awareness;base;Big Data;biomedical informatics;Biometry;Caring;Client;Communities;community engaged research;Community Healthcare;cost effectiveness;cost-effectiveness evaluation;County;court;Criminal Justice;Data;data integration;Data Linkages;Detection;Diffusion;Disease;effectiveness evaluation;Effectiveness of Interventions;effectiveness/implementation study;Funding;Future;General Population;Goals;Health;health data;health disparity;health plan;Health system;Healthcare;Healthcare Systems;high risk;high risk population;implementation science;improved;Individual;Information Systems;Infrastructure;innovation;Intercept;Intervention;Investigational Therapies;Jail;Justice;Learning;Life;Link;Lived experience;Manic;Manuals;men;Mental Health;Methods;Modeling;Morbidity - disease rate;mortality;Movement;multiple data sources;National Institute of Mental Health;novel;Outcome;parole;Pathway interactions;Patients;Persons;Police;Population;Populations at Risk;Prevention;Prevention approach;Prisons;probation;Provider;psychotic;Racial Equity;Records;reducing suicide;Research;Resources;response;Risk;Risk Factors;Risk Marker;screening;severe mental illness;stressor;Structure;substance use;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;System;Target Populations;Testing;Time;trait;Vulnerable Populations;Woman;Work


NIH_SPENDING_CATS: Clinical Research;Health Services;Mental Health;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

PI_NAMEs: JOHNSON, JENNIFER E (contact)

PROJECT_TERMS: Accountability;Address;behavioral health;Caring;Communication;Communities;community partners;Data Linkages;Dedications;design;Development;Discipline;effectiveness/implementation study;Ensure;Evaluation;experience;Family;Feedback;Fostering;Future;Goals;Good Clinical Practice;Growth and Development function;Health;Health Services;Health system;human subject protection;Individual;innovation;Institutional Review Boards;Intercept;Intervention;intervention delivery;Justice;Leadership;Lived experience;meetings;Methodology;Methods;Modeling;National Institute of Mental Health;novel;Outcome;Patients;Pilot Projects;Policies;Practice based research;Process;Productivity;programs;Provider;Regulation;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Role;service delivery;Services;Shapes;Site;Strategic Planning;Suicide prevention;suicide rate;synergism;System;Target Populations;Testing;timeline;training opportunity;Training Support;uptake;videoconference;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: NEW ORLEANS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Project Narrative Sexually transmitted Chlamydia trachomatis infection is the most commonly notifiable disease in the United States. There are substantial knowledge gaps in understanding of Chlamydia trachomatis functional characteristics of essential genes in pathogenesis. We anticipate that the result gained from this proposed study will illustrate the mechanisms underlying the control of developmental gene regulation during C. trachomatis infection and likely provide strategies to target infections by Chlamydia .

PI_NAMEs: SHEN, LI  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Ablation;Address;Bacteria;Bacterial Genome;Bacterial Sexually Transmitted Diseases;Biology;Blindness;Cells;Cervical;Characteristics;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;Consumption;CRISPR interference;Cues;Data;Development;Developmental Gene;Developmental Process;Disease;DNA-Directed RNA Polymerase;Ensure;Epithelial Cells;Essential Genes;Event;experience;Female infertility;flexibility;Flow Cytometry;functional group;Gene Deletion;Gene Expression;Gene Expression Regulation;gene function;gene product;gene repression;Gene Silencing;Gene Targeting;Generations;Genes;Genetic;genetic analysis;genetic manipulation;Genetic Transcription;genome-wide analysis;Glucose;Guide RNA;Health;Human;Individual;inducible gene expression;Infection;innovation;insight;interest;Invaded;Investigation;knock-down;Knowledge;Mediating;Methods;Microscopy;Molecular;molecular phenotype;Morphology;next generation;Organism;Orthologous Gene;Pathogenesis;pathogenic bacteria;Pelvic Inflammatory Disease;Plasmids;Process;promoter;Protocols documentation;Regulation;Regulatory Pathway;Reporter;Research Personnel;Research Project Grants;RNA;Sexual Transmission;Starvation;success;Technology;Testing;Time;tool;Trachoma;trait;Tryptophan;tubal infertility;United States;Variant;vector;Work

PROJECT_TITLE: CRISPR interference of essential stage-specific gene function in Chlamydia trachomatis

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cost Effectiveness Research;Data Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Suicide;Suicide Prevention

PROJECT_TERMS: Area;behavioral health;Big Data;biomedical informatics;Caring;Communication;Communities;Consultations;cost-effectiveness evaluation;Criminal Justice;Data;Data Analyses;Data Analytics;data integration;Data Linkages;Data Set;design;Diffusion;economic evaluation;Educational Intervention;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation study;Electronic Health Record;Ethics;ethnic diversity;evidence base;General Population;Good Clinical Practice;Health;health care service utilization;health economics;health equity;Health Services;Health system;Healthcare;high risk;high risk population;Hybrids;implementation science;Incubated;Individual;Information Systems;innovation;Intercept;Intervention;Jail;Justice;Lived experience;Managed Care;Manuals;Measures;men;Mental Health;Methodology;Methods;Modeling;novel;novel strategies;Outcome;Persons;Pilot Projects;Police;Policies;Population;Populations at Risk;Positioning Attribute;Prevention;Prevention approach;prevention effectiveness;Prevention Research;preventive intervention;Process;Productivity;Public Health;racial diversity;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;response;Risk;Safety;Services;stakeholder perspectives;standard care;Stream;suicidal risk;Suicide;suicide model;Suicide prevention;System;systems research;Target Populations;Time;Training;translational pipeline;Translations;uptake;Woman;Work

PROJECT_TITLE: Methods Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Breast Cancer;Cancer;Estrogen;Genetics;Infectious Diseases;Women's Health Research

ORG_DEPT: NUTRITION

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Narrative Acquired estrogen receptor mutations represent a newly recognized mechanism of endocrine therapy resistance. This project will provide novel insights into the structure-function relationships of drug-resistant mutants at the molecular and cellular level.

PI_NAMEs: YANG, SICHUN  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Adopted;Affect;Amino Acids;Binding;Breast Cancer Cell;Breast Cancer therapy;Cell Physiology;Cell Proliferation;Cells;Communication;Comprehension;Computer Analysis;Computer Models;Cryoelectron Microscopy;Data;density;Disease Resistance;DNA Binding Domain;Drug resistance;ESR1 gene;Estrogen receptor positive;Estrogen Receptors;experimental study;FDA approved;Fluorescence;Fluorescence Polarization;Genetic Transcription;hormonal signals;Hormone Responsive;hormone therapy;Hormones;Human;Hydroxyl Radical;improved;Individual;Inhibition of Cell Proliferation;inhibitor;insight;Intervention;Joints;Ligand Binding;Ligand Binding Domain;Malignant Breast Neoplasm;Maps;Measurement;Mediating;Membrane Proteins;Modeling;Molecular;Molecular Conformation;Mutagenesis;mutant;Mutation;novel;Peptides;Phage Display;Pharmaceutical Preparations;prevent;Proliferating;Property;Protein Footprinting;Publishing;receptor;receptor binding;receptor function;Reporting;Resistance;resistance mutation;Resolution;response;Rest;Roentgen Rays;Role;Site;Site-Directed Mutagenesis;small molecule;small molecule inhibitor;Solvents;Structure;Structure-Activity Relationship;Surface;Techniques;Testing;therapeutic target;Tryptophan

PROJECT_TITLE: Multifaceted integration for estrogen receptor

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care;Social Determinants of Health;Suicide;Suicide Prevention;Telehealth;Violence Research

PI_NAMEs: AHMEDANI, BRIAN KENNETH (contact)

PROJECT_TERMS: Address;Admission activity;Adoption;Area;Attention;Awareness;behavioral health;Books;care coordination;Caring;Clinical;Clinical Data;Collaborations;Communities;Community Healthcare;community setting;Comparison arm;Continuity of Patient Care;coping;cost;cost effectiveness;County;Coupled;Data;data infrastructure;data integration;Data Linkages;design;effectiveness evaluation;Effectiveness of Interventions;effectiveness/implementation trial;Eligibility Determination;Emergency medical service;evidence base;experience;falls;Feeling suicidal;Funding;Future;future implementation;General Population;Goals;healing;Health;health care service utilization;health care settings;Health Services;Health Services Accessibility;Health system;Health Transition;Healthcare;Healthcare Systems;high risk;Hybrids;implementation determinants;implementation evaluation;implementation outcomes;implementation process;implementation strategy;implementation trial;Imprisonment;improved;Individual;Infrastructure;innovation;inpatient service;Intercept;Intervention;Jail;Justice;Legal;Life;Link;Medicare/Medicaid;member;Mental Health;metropolitan;Michigan;Minnesota;National Institute of Mental Health;Notification;Outcome;Outpatients;outreach;Pathway interactions;patient population;Patients;Persons;Population;Population Heterogeneity;prevent;Prevention;Prevention approach;preventive intervention;Process;programs;Provider;Public Health;Randomized;Records;recruit;reducing suicide;Reporting;Research;response;Risk;Safety;Sampling;screening;Services;Site;Standardization;stressor;Structure;Substance Use Disorder;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;System;telehealth;telephone based;Testing;Trauma;treatment arm;treatment as usual;trial design;United States;virtual;vulnerable community;Vulnerable Populations

PROJECT_TITLE: Project 1: Syncing Screening and Services for Suicide Prevention across Health and Justice Systems


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative In accordance with the purpose of the NCI RFA-CA-21-004, this project will accelerate basic and applied cancer research through the development of a molecular technology, which will enable rapid advances in the understand- ing of tyrosine phosphorylation – a process consistently dysregulated in human cancers.

PI_NAMEs: NAEGLE, KRISTEN M (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Acceleration;Acidic Amino Acids;Adoption;Affinity;aggressive breast cancer;Alternative Splicing;anti-cancer research;Bar Codes;Binding Sites;Biochemical;Biological;Breast Cancer Cell;C-terminal;cancer therapy;Charge;Clinic;Computer Models;cost;Darkness;Development;Engineering;Ensure;Epidermal Growth Factor Receptor;epithelial to mesenchymal transition;Escherichia coli;flexibility;Goals;Heart;Human;improved;In Vitro;interest;invention;Libraries;LYN gene;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Molecular;Monitor;Mutagenesis;Pattern;Penetration;Peptides;Phosphopeptides;Phosphoproteins;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphoserine;Phosphothreonine;Phosphotransferases;Phosphotyrosine;Physiological;polyproline;Post-Translational Protein Processing;Process;Production;protein folding;protein function;Proteins;Proteome;Reaction;Reagent;Recombinants;Reproducibility;Research;Role;SH3 Domains;Signal Transduction;Site;Specificity;src-Family Kinases;synthetic protein;System;Tail;Technology;Testing;Therapeutic Intervention;tool;treatment response;tumor progression;Tyrosine;Tyrosine Phosphorylation;Work

PROJECT_TITLE: A synthetic toolkit for the recombinant production of tyrosine phosphorylated proteins and peptides


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: Mandeville

ORG_NAME: HENLEY ION, LLC

PHR: PROJECT NARRATIVE Many infectious diseases, including COVID-19 and tuberculosis, are spread via airborne pathogens that lead to global economic and public health tolls with disproportionate impacts on healthcare workers. Current strategies to protect healthcare workers from airborne pathogens include surgical masks and N95s, but these options have significant limitations in their efficacy, availability, or ease-of-use. By miniaturizing an aerosol particle removal technology called electrostatic precipitation, Henley Ion will provide a comfortable, reusable next-generation respirator that can protect the wearer from airborne pathogens by removing aerosol particles as the wearer breathes.

PI_NAMEs: HENLEY, JULIAN  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: 2019-nCoV;Address;Aerosols;Air;Air Movements;Bacteria;biocontainment facility;Biological Assay;Biological Testing;Breathing;capsule;Cessation of life;Charge;Collection;commercialization;Communicable Diseases;COVID-19;COVID-19 pandemic;current pandemic;design;Development;Device or Instrument Development;Devices;disease transmission;Drops;Economics;Effectiveness;Electronics;Electrons;Electrostatics;Engineering;Ensure;Equipment;Excision;Exposure to;Face;Filtration;Frontline worker;Future;General Population;Generations;global health;Goals;Health care facility;health care settings;Health Personnel;Health protection;Hour;Human;improved;innovation;Ions;Laboratories;Masks;Measures;Medical Device;Methods;microorganism;Microprocessor;miniaturize;Mycobacterium tuberculosis;Nature;next generation;novel;novel strategies;operation;Ozone;pandemic disease;particle;particle counter;Particle Size;pathogen;pathogenic bacteria;pathogenic virus;Pathogenicity;Penetration;Performance;Persons;Phase;Physiological;Precipitation;Predisposition;pressure;Production;prototype;Public Health;Research;Residual state;Resistance;Respiration;Respirators;respiratory;respiratory pathogen;response;Risk;Saline;seal;Small Business Innovation Research Grant;Stream;supply chain;surgical mask;System;Technology;Testing;Time;transmission process;Tuberculosis;Viral;viral pandemic;voltage;wasting;worker safety

PROJECT_TITLE: A micronized electrostatic precipitator for next-generation respiratory protection against pathogenic aerosols


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Suicide;Suicide Prevention

PI_NAMEs: PIMLOTT- KUBIAK, SHERYL M (contact)

PROJECT_TERMS: Accreditation;African American population;Algorithms;Area;Automation;Behavior;Books;Caring;Cessation of life;Communities;Community Health Systems;Continuity of Patient Care;cost;cost effectiveness;County;Coupled;Criminal Justice;Crowding;Data;Data Linkages;data sharing;design;Detection;Disease;Early Intervention;effectiveness/implementation trial;Electronic Health Record;Ethnic Origin;evidence base;Evidence based intervention;experience;Familiarity;Family;Family member;Future;future implementation;General Population;Geography;Goals;Health;health care availability;health care service utilization;Health Care Visit;health data;Health Insurance;Health Insurance Portability and Accountability Act;Health Personnel;health record;Health system;high risk;Human Resources;hybrid type 2 trial;Hybrids;implementation determinants;implementation evaluation;implementation outcomes;implementation process;implementation strategy;improved;Individual;Infrastructure;Institution;Insurance Carriers;insurance claims;Intake;Intercept;Intervention;Jail;Justice;Length;Link;Machine Learning;Medicaid;Medical Records;Mental Health;Methods;Michigan;model development;model generalizability;Modeling;Population;predictive modeling;Process;Provider;racial diversity;Recording of previous events;Records;reducing suicide;Relative Risks;Reporting;Research;Risk;risk prediction model;ROC Curve;Sampling;scale up;screening;Screening procedure;Severities;Standardization;statistics;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;System;Targeted Research;Testing;Thinking;Time;United States Dept. of Health and Human Services;Validation;Work

PROJECT_TITLE: Project 3: Suicide Risk Identification in Jails using Data Linkage and Automation


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Neurosciences;Pediatric;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE One of the least studied and understood complications of type 1 diabetes (T1D) is altered cognition and its relationship to glucose variability; and although a few studies have shown lower cognitive scores associated with diabetes when measured in optimal laboratory settings, little remains known about how typical glucose fluctuations that occur daily in real-life settings affect in-the-moment cognitive function, particularly dynamic cognitive skills that also fluctuate throughout the day. The primary goal of this study is to determine if real-time, real-life glycemic variability predicts fluctuations in dynamic cognitive function in youth with T1D using a unique and innovative combination of continuous health and cognitive data collection methods, multivariate time- series analyses, and machine learning models. This work, combined with a tailored career development plan, will form the basis of my future work as an independent investigator, which will expand to address how diabetes-related health behaviors (e.g., food choice) impact glucose fluctuations, and subsequent brain health (i.e., cognitive function), using mobile health technologies across different types of diabetes (e.g., T1D and type 2 diabetes across the lifespan), with the ultimate goal of improving treatment recommendations and quality of life for these populations.

PI_NAMEs: RAY, MARY KATHERINE OSBORN (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Acute;Address;Affect;Biological;Blood Glucose;Brain;brain health;career development;Childhood;Chronic;Cognition;Cognitive;cognitive function;cognitive performance;cognitive skill;cognitive testing;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Data;Data Collection;Development;Development Plans;Diabetes Mellitus;Diabetic Ketoacidosis;Disease;Educational accommodation;euglycemia;Event;Food;Future;Gestational Diabetes;Glucose;glycemic control;Goals;Health;Health behavior;Health Technology;high standard;Hyperglycemia;Hypoglycemia;improved;Incidence;Individual;innovation;Insulin-Dependent Diabetes Mellitus;Laboratories;Learning;Life;life span;machine learning model;Measures;Methods;mHealth;Non-Insulin-Dependent Diabetes Mellitus;novel;Oxidative Stress;Participant;Patients;Pattern;peer;Population;Prevalence;processing speed;Quality of life;rate of change;Recommendation;Research Personnel;Risk Factors;Short-Term Memory;skills;Sleep Deprivation;smartphone application;Testing;Time;Time Series Analysis;Translating;type I and type II diabetes;Work;Youth

PROJECT_TITLE: Impact of Glucose Variability on Dynamic Cognitive Function in Youth with Type 1 Diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]