NIH_SPENDING_CATS: Aging;Autoimmune Disease;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Estrogen;Menopause;Multiple Sclerosis;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Women's Health Research

PI_NAMEs: HARTLEY, MEREDITH D (contact)

PROJECT_TERMS: Affect;Alzheimer's Disease;Animal Model;Area;Big Data;Biology;Brain;brain health;Centers of Research Excellence;Central Nervous System Diseases;Chemistry;Cholesterol;Cholesterol Esters;Cholesterol Homeostasis;Clinical;Cognitive;Collaborations;Data;data de-identification;Data Set;Demyelinations;Development;Disease;Disease Progression;Electron Microscopy;Estrogen decline;Estrogens;experience;experimental study;FDA approved;Functional disorder;Generations;Genes;Genetic;Goals;Health;High Prevalence;Histology;hormone regulation;Impaired cognition;Impairment;improved;innovation;insight;interdisciplinary approach;Knowledge;Lesion;light microscopy;Link;lipidome;lipidomics;Lipids;Magnetic Resonance Imaging;Maintenance;Maps;Mass Spectrum Analysis;Measures;Medical Records;Membrane;men;Menopausal Syndrome;Menopause;Mentors;metabolic profile;Metabolism;Motor disability;mouse model;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelin;myelination;Nerve Degeneration;Nerve Fibers;Nervous System Disorder;Neurodegenerative Disorders;Neurologic Symptoms;neuron loss;Neurosciences;new therapeutic target;novel;Ovariectomy;Pathway interactions;Patients;Persons;Postmenopause;pre-clinical;Prevalence;Process;Recycling;Regulation;remyelination;repaired;Research;response;Role;Selective Estrogen Receptor Modulators;Services;Severities;Signal Transduction;Spinal Cord;Symptoms;Testing;Therapeutic;therapeutic target;Tissues;white matter;Woman;Women's Health;Women's study;Work

PROJECT_TITLE: Estrogen regulation of cholesterol metabolism during myelin damage and repair


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Ovarian Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Women's Health Research

ORG_CITY: LAWRENCE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PI_NAMEs: WHELAN, REBECCA JEAN (contact)

PROJECT_TERMS: Affinity;Algorithms;Alternative Splicing;Amino Acids;Analytical Chemistry;analytical tool;Antibodies;Antibody Binding Sites;aptamer;Big Data;Binding;Biological Assay;Biological Markers;Biology;biomarker validation;black patient;black women;CA-125 Antigen;cancer biomarkers;cancer care;cancer cell;Cancer Patient;cancer recurrence;Cell Line;cell type;Cells;Centers of Research Excellence;Chemicals;Cisplatin;Clinical;Clinical Management;Complex;Core Facility;Detection;Development;Diagnosis;diagnostic value;Disease remission;Early Diagnosis;Epitopes;ethnic difference;Exposure to;Failure;Funding;Glycoproteins;glycosylation;Goals;Gynecologic Oncologist;Immunoassay;immunogenicity;improved;Individual;individual variation;innovation;invention;Knowledge;Life Cycle Stages;Location;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Masks;Mass Spectrum Analysis;Measures;Mentors;Messenger RNA;Modification;Molecular;Monitor;Mucins;novel;ovarian neoplasm;Patients;Performance;Phenotype;Platinum;Play;Polysaccharides;Positioning Attribute;programs;Protein Glycosylation;Proteins;Proteomics;Publishing;Race;racial difference;Reagent;Recurrence;Reporting;Research;research clinical testing;Research Personnel;Research Project Grants;Risk;RNA Splicing;Role;Screening for Ovarian Cancer;Serous;Serum;Serum Markers;Source;Spectrum Analysis;spheroids;Surface Plasmon Resonance;System;Tandem Repeat Sequences;Tertiary Protein Structure;Testing;tool;Tracer;treatment response;tumor;United States National Institutes of Health;Variant;White Women;Woman;Women's Health;Work

PROJECT_TITLE: Clarifying the roles of glycoprotein sequence and cancer cell phenotype on the immunogenicity of ovarian cancer biomarker CA125

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-9 (C1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Caregiving Research;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Primary Health Care;Rural Health;Social Determinants of Health;Telehealth;Women's Health Research

PI_NAMEs: HEGGENESS, MISTY  (contact)

PROJECT_TERMS: Acceleration;access restrictions;Affect;American;Area;Big Data;Big Data Methods;Budgets;care burden;Caregiver well-being;Caregivers;Caring;Censuses;Cessation of life;Characteristics;Child;Child Care;Community Surveys;Consumption;cooking;Country;COVID-19;COVID-19 pandemic;Creativeness;Data;data cleaning;Data Set;Demographic Analyses;disease diagnosis;Eating;econometrics;Economics;Electronic Health Record;Emotional;Equity;exhaustion;Family;Family member;Farm;firewall;Food;food preparation;Future;Geography;Goals;Grant;Health;health care availability;health data;Health Personnel;Health Policy;Health Services;Health system;Hour;Household;improved;Infrastructure;innovation;instrument;Kansas;Life;Link;Long-Term Care for Elderly;Medical;Mentors;Midwestern United States;Mothers;next generation;Outsourcing;pandemic disease;pandemic impact;Parents;Personal Satisfaction;Policies;Policy Maker;Population;population health;post-pandemic;Preventive care;Production;programs;Provider;Public Health;rate of change;Records;remote delivery;remote health care;Research;Resources;Restaurants;Risk;Rural;rural area;Rural Community;rural families;rural patients;Rural Population;screening;service delivery;Service provision;Services;social;Stress;Stretching;Taxes;Techniques;Technology;Telemedicine;Time;Travel;trend;virtual;virtual healthcare;Woman;Women's Health;Work

PROJECT_TITLE: Telemedicine, Caregivers, and Rural Population Health


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Women's Health Research

PI_NAMEs: WATTS, AMBER  (contact)

PROJECT_TERMS: acceptability and feasibility;Accounting;Address;Adherence;Adopted;Adoption;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;American;Awareness;Behavior;behavior change;Behavior Therapy;Big Data;Bioinformatics;bioinformatics tool;Blood Pressure;Blood Tests;Body Composition;Body mass index;Brain;cardiometabolism;Career Mobility;Centers of Research Excellence;Clinical;Collaborations;cost;Data;Data Set;design;Diagnosis;Diet;diet and exercise;Disclosure;Disease;disorder risk;Disparity;E-learning;Education;Educational Intervention;Electronic Health Record;Exercise;fasting glucose;Fatty acid glycerol esters;Female;Frequencies;Future;Genetic;Goals;Grant;Health;Health behavior;Health behavior change;health organization;Health Promotion;High Density Lipoproteins;high risk;Hormonal;Hormonal Change;improved;Individual;innovation;Intention;Intervention;intervention program;Interview;Knowledge;LDL Cholesterol Lipoproteins;Learning Module;Life Expectancy;Life Style;lifestyle intervention;lifetime risk;Lipids;Menopause;Mentorship;middle age;Midlife women;Modality;Modeling;Motivation;Movement;multimodality;older adult;online delivery;Participant;Patient Recruitments;Patient Self-Report;Physical activity;Positioning Attribute;prevent;Prevention program;programs;psychologic;Questionnaires;Randomized;Randomized, Controlled Trials;recruit;Research;Research Support;Resources;Risk;Risk Assessment;Risk Factors;risk perception;Risk Reduction;Secure;Self Efficacy;Services;sex;sex disparity;skills;Sleep;Social support;Societies;Specialist;Stress;Structure;success;sugar;Support Groups;Symptoms;Testing;Time;timeline;Triglycerides;waist circumference;Waiting Lists;Woman;Women's Health;Writing

PROJECT_TITLE: Women's Alzheimer's Risk Reduction in Midlife


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Rural Health;Social Determinants of Health;Women's Health Research

PI_NAMEs: SAINT ONGE, JARRON M. (contact)

PROJECT_TERMS: Alcohol consumption;Alcohols;Area;Behavior;behavior change;Behavioral;Benefits and Risks;Big Data;Body mass index;Centers of Research Excellence;Characteristics;Country;County;COVID-19;Data;data infrastructure;Data Set;data sharing;Data Sources;Dedications;Demographic Factors;Demography;Disadvantaged;disadvantaged women;driving force;Economics;Ethnic Origin;experience;Future;Goals;Grant;Growth;Health;Health behavior;health care availability;health care service utilization;health data;health difference;Health Services Accessibility;healthspan;Immigrant;Immigration;improved;Individual;Individual Adjustment;Intervention;Investments;Knowledge;Life Style;Maternal Mortality;men;Mentors;Metabolic Diseases;Migrant;migration;mortality;Occupations;Out-Migrations;Pathway interactions;Pattern;Pharmaceutical Preparations;Physical activity;Poisoning;Policies;Population;Population Dynamics;Poverty;programs;Race;Research;Research Personnel;Resources;response;Retirement;Risk;Risk Factors;Role;Rural;rural area;rural counties;Rural Health;rurality;Saints;Smoking;social;Social Change;social factors;sociodemographics;Socioeconomic Status;Time;trend;Typology;Unemployment;United States National Institutes of Health;Urbanization;Woman;Women's Health;Women's mortality;Work

PROJECT_TITLE: Rural Health Lifestyles: The role of demographic change and migration shifts on rural women's health


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Diabetes;Nutrition;Obesity;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: LUBBOCK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: TEXAS TECH UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative Aging people with prediabetes are at increased risk for frailty, and skeletal muscle architectural factors (which may improve with exercise or heat therapy) could underlie development of frailty and progression to type 2 diabetes. The proposed study will test local heat therapy as a method to improve skeletal muscle architecture (i.e., cross sectional area, capillarization, mitochondria), glucose tolerance, and frailty indicators in prediabetic older adults. Data generated will provide evidence supporting a directly translatable, easily implemented therapeutic intervention to ameliorate risk of developing overt type 2 diabetes and frailty in at-risk aging individuals.

PI_NAMEs: LEVITT, DANIELLE E;LUK, HUI YING  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Adherence;Adult;Aerobic Exercise;Age;Aging;aging population;Alternative Therapies;Architecture;Area;Attenuated;Biogenesis;Blood capillaries;Body Weight decreased;Capillarity;Cardiovascular system;Categories;Characteristics;combat;Communities;cost;Data;Development;Diabetes Mellitus;diabetes risk;diabetic;disease model;Exercise;exercise capacity;exercise intervention;Exercise Therapy;exercise training;Exposure to;Fatigue;frailty;Gait speed;glucose disposal;glucose tolerance;glycemic control;Growth;Health Benefit;Heat Stress;Human;Impairment;improved;Individual;Insulin;Interval training;Intervention;Ion Channel;Maintenance;Maximum Heart Rate;Medical Care Costs;Metabolic;Metabolic Diseases;Methods;Mitochondria;Modality;mode of exercise;Muscle;Muscle Fibers;muscle form;Muscle function;Musculoskeletal Pain;Non-Insulin-Dependent Diabetes Mellitus;Obesity;older adult;Older Population;Oxygen;Permeability;Persons;Pharmacological Treatment;Phenotype;Physical activity;Populations at Risk;preconditioning;Prediabetes syndrome;prevent;preventive intervention;Proteins;receptor;reduced muscle strength;Research;Resistance;resistance exercise;Respiratory Chain;response;Risk;Rodent;sarcopenia;Sarcoplasmic Reticulum;Signal Induction;Site;Skeletal Muscle;Techniques;Testing;Therapeutic heat application;Therapeutic Intervention;Time;Training;TRPV1 gene;vanilloid receptor subtype 1;Work

PROJECT_TITLE: Glycemic control and frailty risk in older people at risk for type 2 diabetes: Impact of local heat therapy

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Breast cancer is the most common cancer in women worldwide and among the leading causes of death in women, and the vast majority of breast cancer deaths result from tumor recurrence at distant sites following treatment. Understanding how tumor cells survive treatment, persist as dormant cells, and eventually reinitiate malignant growth is essential to developing therapies to kill dormant cells and prevent breast cancer recurrence. We have previously studied the regulation and function of the tumor suppressor protein Par-4 in breast cancer recurrence, and in this proposal, we will build on our previous work to elucidate how regulation of cell contractility contributes to Par-4’s function as a tumor suppressor.

PI_NAMEs: ALVAREZ, JAMES V (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Actomyosin;Animal Model;Apoptotic;Biomechanics;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Prevention;breast cancer progression;Breast Epithelial Cells;cancer cell;Cancer Etiology;cancer recurrence;Cause of Death;Cell Death;Cell Survival;Cells;Cessation of life;Clinical;cohort;Data;Development;Disease;Dissection;Distant;Down-Regulation;Duct (organ) structure;E-Cadherin;Event;Exhibits;Genetically Engineered Mouse;Goals;Growth;Human;improved;Knock-out;Laboratories;Lobular;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Modeling;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel;Oncogenes;Pathway interactions;Patients;PAWR gene;PAWR protein;prevent;Process;Prognosis;Proliferating;Recurrence;Recurrent disease;Recurrent tumor;Regulation;Relaxation;Research;Residual Cancers;Residual Neoplasm;Residual state;response;Risk;Role;Sampling;Signal Pathway;Site;Specimen;targeted treatment;Testing;Therapeutic Intervention;therapy design;therapy development;therapy resistant;three dimensional cell culture;tumor;tumor progression;Tumor Suppressor Proteins;Woman;Women's mortality;Work

PROJECT_TITLE: Par-4 Regulation of Actomyosin Contractility as a Tumor Suppressive Mechanism in Breast Cancer

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Project Narrative Organ transplantation as a lifesaving therapy remains constrained by relentless loss of transplanted organs over time and complications associated with lifelong immunosuppression. Our proposal is designed to uncover novel epigenetic mechanisms that can be targeted to promote transplant survival. Our proposed studies will uncover novel insights and open new therapeutic opportunities in transplant tolerance induction as well as in treatment of autoimmune diseases and cancer.

PI_NAMEs: LI, XIAN CHANG (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: 3-Dimensional;Acetylation;Address;Affect;Alloantigen;Allograft Tolerance;Allografting;Animal Model;Area;ATAC-seq;Autoimmune;Autoimmune Diseases;Binding;Cell Aging;ChIP-seq;Chromatin;chromatin modification;chromatin remodeling;Chromatin Structure;cofactor;Complex;computerized data processing;Cytokine Receptors;Data;design;Effector Cell;effector T cell;Enhancers;Epigenetic Process;epigenome;Eragrostis;exhaustion;Family member;Gene Expression Profile;Genes;Genetic Transcription;Genetically Modified Animals;Genome Stability;genome-wide;Goals;Graft Survival;heart allograft;Heart Transplantation;Heterochromatin;Hi-C;Histone Acetylation;Histones;Hyperactivity;Immunosuppression;improved;in vivo;inhibitor;insight;Life;LoxP-flanked allele;Malignant Neoplasms;Mediating;metabolic fitness;Modeling;multiple omics;Mus;novel;novel therapeutics;Organ Transplantation;Outcome;Pathway interactions;pharmacologic;Phenotype;Positioning Attribute;Process;programs;promoter;Protein Family;Reader;recruit;Regulatory Element;Research;response;Role;Signal Transduction;Site;Specific qualifier value;Structure;T-Cell Activation;T-Cell Development;T-Lymphocyte;Tamoxifen;Tea;Technology;Testing;therapeutic target;Time;tool;transcription factor;Transgenic Organisms;transplant model;Transplantation;Transplantation Tolerance

PROJECT_TITLE: Modulation of chromatin dynamics to promote transplant survival

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: This proposal will examine non-invasive, in vivo EEG-based measures of neuroplasticity (the brain’s ability to alter its function or structure in response to changes in the environment or novel experiences) in Veterans with schizophrenia (SCZ) or traumatic brain injury (TBI). Despite the vastly different etiologies of these disorders (SCZ is a neurodevelopmental disorder; TBI is acquired), both have impaired cognition which is linked to poor community functioning and integration. Our understanding of the root causes of complex cognitive impairments remains limited. Neuroplasticity is a fundamental brain process that underlies cognitive functioning making it a very attractive area for clinical investigation as it provides a basic mechanistic understanding (at the cellular and neural levels) of what causes cognitive dysfunction in TBI and SCZ. The current application is the start of a systematic research program dedicated to understanding the mechanisms contributing to poor cognition in TBI and SCZ, and examine objective biomarkers of neuroplasticity that can be applied to future interventions.

PI_NAMEs: WYNN, JONATHAN  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Animals;Area;Attention;Auditory;behavior measurement;Biological Markers;Brain;clinical investigation;Clinical Trials;Cognition;Cognition Disorders;Cognitive;Cognitive deficits;cognitive function;cognitive neuroscience;cognitive process;Cognitive remediation;Community Integration;Complex;Data;Dedications;design;Disease;efficacy evaluation;Electroencephalography;Emotions;Empathy;Employment;Environment;Etiology;Evaluation;experience;Family;Financial Hardship;Frequencies;functional outcomes;Future;Healthcare Systems;Human;Impaired cognition;Impairment;improved;in vivo;Independent Living;Individual;Intervention;Knowledge;Learning;Life;Link;Long-Term Potentiation;Los Angeles;Measures;Memory;Mental Health Services;Methods;neural;Neurodevelopmental Disorder;Neuronal Plasticity;neurophysiology;Neurosciences;novel;Outcome;Participant;Patient Self-Report;Patients;Pattern;Pilot Projects;poor communities;Population;Process;process improvement;programs;Property;psychopharmacologic;psychosocial;recruit;Research;Resected;response;Role;Running;Sampling;Schizophrenia;Schools;Services;short-term potentiation;social;Social Network;Structure;System;theory of mind;therapy development;Tissues;tool;Training;Translating;translational approach;Traumatic Brain Injury;Treatment Cost;Treatment Efficacy;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Visual;Work

PROJECT_TITLE: New Applications of Neuroplasticity Biomarkers in Veterans with Traumatic Brain Injury or Schizophrenia

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: ANN ARBOR

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The proposed research study will investigate the interaction of tobacco control policies on youth smoking disparities, and the influence of tobacco control policies on youth e-cigarette use and related disparities. The proposed research project compliments and expands on the aims of the parent R37, The Impact of Tobacco Control Policies on Health Equity in the United States (R37CA214787), and will contribute to the parent grant’s goal for understanding the health equity impact of tobacco control policies in the United States.

PI_NAMEs: FLEISCHER, NANCY  (contact)

PROGRAM_OFFICER_NAME: MAYER, MARGARET ELIZABETH

PROJECT_TERMS: Address;Adoption;Adult;Affect;attributable mortality;Award;Canada;comparative;Data;Data Sources;Databases;design;Development;Disparity;disparity reduction;Education;electronic cigarette use;Environment;ethnic minority;Ethnic Origin;Ethnic Population;evidence base;Family;Funding;Future;Gender;Goals;Grant;Health;health disparity;health disparity populations;health equity;health warning;Income;Investments;Knowledge;low socioeconomic status;marginalized population;Mass Media;Media Campaign;Mind;Modeling;models and simulation;Monitor;movie;National Cancer Institute;Outcome;parent grant;Parents;Persons;Policies;Policy Analysis;Policy Maker;Population;population based;population survey;prospective;public policy on tobacco;Race;racial minority;Research;Research Project Grants;research study;Sales;sex;smoke-free policy;Smoking;smoking cessation;smoking initiation;smoking prevalence;sociodemographics;Socioeconomic Status;socioeconomics;Special Population;Subgroup;success;supplemental instruction;Surveys;Taxation;Testing;Time;time use;Tobacco;Tobacco 21 policies;Tobacco Control Research;Tobacco use;United States;Variant;warning label;Work;Workplace;Youth

PROJECT_TITLE: The Impact of Tobacco Control Policies on Health Equity in the United States - MERIT Extension


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project narrative Understanding the genetic causes of arrhythmias and sudden cardiac death may lead to improved treatment and prevention of these conditions. Our proposal will leverage a unique and massive resource of individuals with high-depth sequencing data and electrocardiograms to discover genetic variation related to cardiac conduction abnormalities. By further examining the function of newly identified genes and linking genetic discoveries to clinical impact and outcomes, we will improve our understanding of individuals at greatest risk for arrythmias and sudden cardiac death before adverse events occur.

PI_NAMEs: ELLINOR, PATRICK THOMAS (contact);MIRSHAHI, TOORAJ

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Address;adjudication;Adverse event;Affect;Arrhythmia;biobank;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;causal variant;Cellular Assay;Classification;Clinical;Clinical Data;clinical phenotype;clinical practice;clinically relevant;ClinVar;Code;cohort;Collection;Data;data submission;Diagnostic;Disease;EKG P Wave;Electrocardiogram;Electronic Health Record;Electrophysiology (science);endophenotype;exome;exome sequencing;Fibroblasts;Genes;Genetic;genetic testing;genetic variant;Genetic Variation;genome sequencing;Genomics;Goals;Healthcare;Heart Diseases;Heritability;high throughput screening;Human Genetics;improved;Individual;innovation;large scale data;Link;Long QT Syndrome;Measurement;Measures;Medical Genetics;Methods;Mission;Morbidity - disease rate;mortality risk;National Heart, Lung, and Blood Institute;novel;Outcome;Pathogenicity;Persons;Physiological Processes;population based;Prevention;Prognosis;programs;Proliferating;Proxy;Public Health;rare variant;repository;Reproducibility;Resources;response;Risk;risk stratification;Sampling;Science;screening;stem cells;sudden cardiac death;Testing;trait;Trans-Omics for Precision Medicine;Translations;transmission process;Validation;Variant;variant of unknown significance;whole genome

PROJECT_TITLE: Using Electrocardiogram Genetics to Inform Arrhythmia Risk

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative The goal of the proposed research is to optimize a novel x-ray fluorescence emission tomography system capable of directly imaging metal maps in biological samples and if desired, jointly estimate the metal and attenuation maps. The proposed system will provide the spatial resolution, sensitivity, and tissue penetration depth needed to image gold nanoparticles in small animal models, paving the way to in vivo guiding and monitoring metal-mediated radiation therapy and photothermal ablation cancer therapy.

PI_NAMEs: DEBROSSE, HADLEY ANNA (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Ablation;Algorithms;Animal Model;attenuation;Biological;Brain;cancer care;cancer therapy;Clinic;Clinical;clinical imaging;Clinical Research;Clinical Trials;Data;density;design;detector;Dose;Drug Delivery Systems;Elements;Failure;Fluorescence;fluorescence imaging;Geometry;Goals;Gold;Human body;Illinois;Image;image reconstruction;imaging modality;imaging system;improved;In Vitro;in vivo;Investigation;Joint repair;Location;Malignant Neoplasms;Maps;Measurement;Measures;Mediating;Meditation;Metals;Methods;Modality;Modeling;Monitor;Monte Carlo Method;mouse model;Mus;nanoGold;Noise;novel;Organism;particle;Penetration;phantom model;Play;Positioning Attribute;pre-clinical;Property;Radiation Dose Unit;Radiation therapy;Radiation-Sensitizing Agents;Radioactivity;Radiosensitization;reconstruction;Research;Resolution;Roentgen Rays;Role;Sampling;Scanning;side effect;Spatial Distribution;Specific qualifier value;Superficial Lesion;System;Techniques;Therapeutic;Thermal Ablation Therapy;Time;Tissues;tomography;Translating;transmission process;tumor;Universities;Work;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: X-ray fluorescence emission tomography for imaging trace gold in mouse models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-P(20)L]


ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Project Narrative IMSD at Texas A&M University: Initiative for Maximizing Student Diversity in Biomedical Sciences This program will increase diversity of doctoral trainees in biomedical sciences at Texas A&M University. Six major biomedical graduate training programs: Medical Sciences, Biomedical Sciences, Genetics, Toxicology, Biochemistry & Biophysics, and Biomedical Engineering are joining with the Office of Graduate and Professional Studies to create a cohesive learning community and a community of scholars to foster recruitment and retention of underrepresented minority populations of trainees. Didactic, research, experiential and career development activities will foster development of the future biomedical professionals who are highly successful in academia, industry, government and other professional settings.

PI_NAMEs: BRINKMEYER-LANGFORD, CANDICE L.;CHIU, WEIHSUEH A;KAUNAS, ROLAND RAYMOND;RUSYN, IVAN ;SHIPPEN, DOROTHY ;THREADGILL, DAVID W.;WALTON, SHANNON  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Science;Students;Texas;Universities

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE The purpose of this application is to better understand heart failure among people with human immunodeficiency virus (HIV). People with HIV have much higher risks for heart failure than the general population for reasons that are not adequately understood. Our goal in this application is to fundamentally improve how heart failure is understood in HIV, with the ultimate goal of improving heart failure prevention and treatment in HIV.

PI_NAMEs: FEINSTEIN, MATTHEW JOEL (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: abacavir;Address;adjudication;aging population;American Heart Association;Anti-Retroviral Agents;antiretroviral therapy;Autopsy;Biological Markers;Biological Specimen Banks;Biology;candidate marker;Cardiac;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;case control;CD4 Lymphocyte Count;CD8B1 gene;Cells;Clinical;clinical care;Clinical Data;clinical imaging;clinical risk;clinically relevant;cohort;comorbidity;Complex;Data;design;Diabetes Mellitus;Diagnosis;EFRAC;Endothelium;Epidemiology;Event;Female;Fibroblasts;Freezing;Functional disorder;Funding;Gene Expression;General Population;Genes;Goals;Heart failure;Heart Rate;hemodynamics;High Prevalence;high risk;Hispanic;HIV;Hypertension;Immune;Immune response;Immune System Diseases;Immunologics;immunoregulation;Impairment;improved;Individual;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;insight;Intervention;Investigation;kidney dysfunction;Knowledge;Link;Longevity;male;Maps;Methods;middle age;migration;Modernization;monocyte;mortality;Multicenter Studies;multidisciplinary;Myocardial;Myocardial tissue;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;novel;Obesity;overexpression;Pathogenesis;Patient Outcomes Assessments;Patients;Pattern;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phenotype;power analysis;Predisposition;preservation;Prevention;protein biomarkers;Proteins;Proteomics;Protocols documentation;Recovery;Regulation;Regulatory T-Lymphocyte;Request for Proposals;Research;Research Priority;Resolution;response;Risk;Risk Factors;RNA;Role;Sampling;screening;senescence;Specimen;Structural defect;Syndrome;T-Cell Activation;T-Lymphocyte;targeted treatment;Therapeutic Intervention;Time;Tissues;trafficking;transgender;United States;Update;Validation;Weight Gain;Writing

PROJECT_TITLE: Immunologic, Inflammatory, and Clinical contributors to HIV-Related Heart Failure with Preserved Ejection Fraction (HFpEF)

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative: We propose to study the molecular and cellular mechanisms underlying stress susceptibility and resilience. We will examine adaptations in key brain reward neuronal and non-neuronal cells in social stress and the impact on reward behaviors. Our studies will provide new information into the neuronal and non-neuronal cell types in key a reward brain region in social stress, which can impact our understanding of many psychiatric illnesses affecting reward and motivation.

PI_NAMEs: LOBO, MARY KAY  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Affect;Atrophic;Autopsy;Behavior;behavioral construct;behavioral outcome;Biological Process;Bipolar Disorder;Brain;brain reward regions;cell type;Cells;Chronic;CSF1 gene;Data;Dopamine Receptor;Dorsal;efficacious treatment;Female;Foundations;Future;Globus Pallidus;Hypothalamic structure;improved;Individual;inducible Cre;Inflammatory Response;knock-down;Label;Lateral;Ligands;Link;Macrophage Colony-Stimulating Factor Receptor;Major Depressive Disorder;male;Mediating;Mental Depression;Mental disorders;Messenger RNA;Microglia;Molecular;molecular subtypes;Morphology;motivated behavior;Motivation;Mus;Neuroglia;neuronal circuitry;Neurons;Nucleus Accumbens;Outcome;Phenotype;Play;Population;Positive Valence;Post-Traumatic Stress Disorders;Predisposition;prevent;Process;promote resilience;research and development;resilience;resilient behavior;response;reward circuitry;Rewards;Ribosomes;RiboTag;Risk Factors;Rodent;Role;Schizophrenia;sex;Shapes;Signal Transduction;social defeat;social stress;Stress;stress resilience;Structure;Symptoms;Testing;Therapeutic;tool;transcriptome;transcriptome sequencing;translatome;Ventral Tegmental Area;Virus;Work

PROJECT_TITLE: Cell Subtype Mechanisms Underlying Stress Susceptibility and Resilence


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Microglial neuroimmune interactions and retrograde trafficking via the retromer complex are critical cellular processes in Alzheimer’s disease (AD) pathobiology and dementia. Previous studies have focused on the effects of retromer risk genes in neurons, but emerging genetic evidence implicates microglia, the brain’s resident macrophages, in the pathogenesis of AD. This proposal aims to characterize the effects of retromer disruption on neuron-microglia crosstalk involved in neurodegeneration using mouse and stem cell-derived models combined with novel proteomics tools to identify endosomal signaling changes.

PI_NAMEs: MORSHED, NADER FRANCIS (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid precursor protein processing;Astrocytes;Binding;Binding Proteins;Brain;brain cell;Brain region;Cell Physiology;Cell surface;cell type;Cells;Communication;Complement;Complement component C4;Complex;conditional knockout;cytokine;Dementia;dementia risk;Disease Progression;Endosomes;Environment;Event;examination questions;experimental study;Functional disorder;Genes;Genetic;Genetic Engineering;Genetic Risk;Genetic study;Genetic Transcription;Genetically Engineered Mouse;glial activation;Gliosis;Goals;Healthcare Systems;Hippocampus;Human;human model;human pluripotent stem cell;Impairment;in vivo;Inflammation;insight;Lead;Learning;lens;Link;Macrophage;Mediating;Memory;Microglia;Molecular;molecular pathology;Mus;Mutate;Mutation;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;neurogenesis;Neuroglia;Neuroimmune;Neurons;novel;Organelles;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;prevent;Production;protein aggregation;Protein Secretion;protein transport;Proteins;Proteome;Proteomics;receptor;Recycling;Research;Risk;risk variant;Role;scaffold;secretion process;Signal Pathway;Signal Transduction;stem cell model;Stroke;Synapses;System;tau Proteins;Technology;Testing;Time;tool;trafficking;trans-Golgi Network

PROJECT_TITLE: Molecular impact of endolysosomal dysfunction on neuron-glia communication pathways


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Essential tremor (ET) is a chronic and progressive neurological disease affecting 7 million individuals in the US, making it the most common tremor disorder, yet its underlying patho-mechanisms remain enigmatic. The study of human tissue is currently the most direct method to gain a mechanistic insight into the pathogenesis of ET, and in 2003, we established the Essential Tremor Centralized Brain Repository, harvesting 217 ET brains to date, by far the largest collection of ET brains in the world. Through detailed, systematic, controlled postmortem studies, we have made initial steps in identifying postmortem changes in the ET brain, yet in fundamental ways, our studies have only grazed the surface; we have yet to fully map the degenerative pattern seen in the ET brain and have made only initial attempts to dig deeper to begin to uncover the molecular events that are responsible for this disease.

PI_NAMEs: FAUST, PHYLLIS L (contact);LOUIS, ELAN D

PROGRAM_OFFICER_NAME: CHO, HYUN JOO

PROJECT_TERMS: Affect;Age;American;Anatomy;Animal Model;Autopsy;axon guidance;Biological;Biological Process;Brain;brain control;Brain region;Case Study;Catalogs;Cell Nucleus;cell type;Cerebellar Cortex;Cerebellar Nuclei;Cerebellum;Chorea;Chronic;Clinical;clinical phenotype;Collection;Complement;Curiosities;Data;Dentate nucleus;Disease;disease model;Dystonia;Essential Tremor;Event;experimental study;Genetic;Genomics;Harvest;human disease;human tissue;Individual;Inferior;insight;Knowledge;laser capture microdissection;Learning;Maps;Mass Spectrum Analysis;Methods;Molecular;Motor Cortex;Nerve Degeneration;Nervous System Disorder;Neurons;neuropathology;Olives - dietary;Organ;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Phenotype;Physiological;Population;Postmortem Changes;protein expression;Proteome;Proteomics;Publishing;Purkinje Cells;Red nucleus structure;repository;Sampling;Site;Structure;Surface;Synaptic Transmission;Testing;Thalamic structure;Tissues;transcriptome;transcriptome sequencing;Tremor

PROJECT_TITLE: Deep Dive: Mapping the Neuropathology of Essential Tremor and Exploring the Molecular Underpinnings of Neurodegeneration

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: Relevance Recognizing the importance for understanding age-associated metabolic changes in Alzheimer’s Disease (AD), we propose to quantify aging- and AD-associated brain and blood metabolic changes through ex vivo and in vivo multimodality MR measurements in mouse models after an AD-promoting stimuli, anesthesia- surgery, with-or-without preventive, protective treatments. This approach recognizes that AD onset, pathogenesis and progression must produce alterations in the overall metabolic status, or metabolomics, of brain and other organs in AD patients, as compared with normal homeostasis in healthy individuals, and our understanding of the urgent need to develop non-invasive AD diagnosis tools. The goal of project is thus to establish translational protocols to guide and interpret multimodality in vivo MR imaging results, based on precise measurements from ex vivo MRS, EM, and immunochemistry studies of the animal models, particularly ex vivo MRS measurements, which are difficult or impossible to conduct in human brain tissues. Success in our project can supply information critical to guiding protocol design and interpretation for in vivo multimodality MR results from human patients, thereby providing a foundation for developing methods of non- invasive detecting and monitoring of age-associated AD metabolomic changes for use in the human AD clinic, an urgently needed capability that to date has remained elusive.

PI_NAMEs: JENKINS, BRUCE G (contact);XIE, ZHONGCONG

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: AD transgenic mice;Aftercare;Age;age related;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Anesthesia procedures;Animal Behavior;Animal Model;Animals;Anti-Inflammatory Agents;Apoptotic;arm;behavior test;Blood;Brain;Brain region;brain tissue;Clinic;Clinical;Clinical Protocols;cohort;Cyclosporine;design;Development;Diffusion Magnetic Resonance Imaging;Electron Microscope;Evaluation;Foundations;Functional Magnetic Resonance Imaging;Gluconeogenesis;Glucose;Goals;Homeostasis;Hour;Human;Image;Immunochemistry;Impairment;in vivo;in vivo imaging;in vivo magnetic resonance spectroscopy;Individual;Intervention;Knock-out;Label;life span;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Metabolic;metabolomics;Methods;Mitochondria;mitochondrial dysfunction;Monitor;morris water maze;mouse model;multimodality;Mus;myelination;neuroinflammation;Non-Invasive Detection;non-invasive monitor;noninvasive diagnosis;normal aging;novel;Onset of illness;Operative Surgical Procedures;Organ;Pathogenesis;Pathway interactions;Patients;Predisposition;Preventive;Procedures;Protocols documentation;quantification of aging;Rest;Serum;Stimulus;success;Technology;Testing;Time;Tissue Harvesting;Tissues;tool;Training;Transgenic Organisms;Translating;Validation;Vitamin K 2;Wild Type Mouse

PROJECT_TITLE: Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuli

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Women Veterans commonly experience urinary incontinence (UI) and may be at increased risk due to exposures during military service. Nonsurgical UI treatments are widely recommended by guidelines as first- line treatment options because of their demonstrated effectiveness and low risk of side effects. Given the identified need to improve access to UI treatments for women Veterans, we will implement a clustered randomized clinical trial of an interactive mobile-health application with and without booster clinical video telehealth visits and utilize practice facilitation as an implementation strategy for primary care practices, while also exploring patient and provider perceptions using a mixed-methodology approach.

PI_NAMEs: MARKLAND, ALAYNE DENISE;VAUGHAN, ELIZABETH CAMILLE;ZUBKOFF, LISA  (contact)

PROGRAM_OFFICER_NAME: NIEBUHR, DAVID

PROJECT_TITLE: Improving Primary Care Understanding of Resources and Screening for Urinary Incontinence to Enhance Treatment (PURSUIT)


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE An ongoing challenge in the biomedical sciences is to recruit, train, retain and launch the broadest and most diverse scientific talent pool possible. At the University of Utah, we are poised to take advantage of sustained and unprecedented successes recruiting underrepresented students, in the state with the highest recent growth in the life sciences industry. By developing and innovating programs and strategies for inclusion and retention, we aim to mentor and prepare our IMSD@U2 Trainees and Scholars, establishing their careers as outstanding scientists and leaders in the biomedical sciences, while also developing and fostering our own research-intensive environment where underrepresented scientists can flourish.

PI_NAMEs: KWAN, KRISTEN M (contact);ROH, MINNA

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Universities;Utah

PROJECT_TITLE: IMSD at the University of Utah (IMSD@U2)


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: MILWAUKEE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Public health relevance. Extensive genomic information now exists for Anopheles mosquitoes, but a significant gap remains in associating the extensive nucleotide variation with relevant disease phenotypes. Across all organisms, the ability to link changes in genotype with disease phenotype is complicated by the fact that variation in protein-coding genes explains only a small proportion of the genetic basis of phenotypes. We will fine-map the portion of the mosquito genome linked to malaria infection and dissect the function of genetic variation present in noncoding and coding sequence that is likely to influence mosquito biology and malaria transmission.

PI_NAMEs: RIEHLE, MICHELLE M (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Africa;Alleles;Animals;Anopheles gambiae;Anopheles Genus;Behavior;Biological;Biological Assay;Biology;Bite;Blood;Cell Line;Chromosome Arm;Chromosomes;Code;Complex;Control Locus;CRISPR/Cas technology;Culicidae;Data;Detection;detection assay;disease phenotype;Dissection;DNA;Elements;Enhancers;feeding;Frequencies;Gene Expression;Gene Silencing;Genes;Genetic;genetic analysis;Genetic Enhancer Element;Genetic Markers;genetic pedigree;Genetic Polymorphism;Genetic Recombination;Genetic Variation;Genetic Vectors;Genome;genome editing;genome resource;genome-wide;genomic locus;Genomics;Genotype;Goals;Individual;Infection;innovation;Insecticide Resistance;insight;Link;Malaria;malaria infection;malaria transmission;Maps;meetings;member;Messenger RNA;MicroRNAs;Nature;novel;Nucleotides;Organism;Outcome;Phenotype;Plasmodium;Plasmodium falciparum;Population;Positioning Attribute;Predisposition;Prevalence;Proteins;public health relevance;Publishing;Regulatory Element;Resistance;Resolution;Science;Source;Susceptibility Gene;Technology;Testing;Time;tool;transcriptome sequencing;Untranslated RNA;Variant;vector;vector competence;Vector Ecology;vector mosquito

PROJECT_TITLE: Noncoding DNA regulatory elements and Anopheles vector biology

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Yuma County, Arizona is an agricultural hub producing more than 90% of the leafy greens consumed in the United States during winter with application of more than 2.6 million kilograms of pesticides per year. My previous quantitative research demonstrated concentrations of neurotoxic metals (e.g., copper [Cu] and manganese [Mn]) consistent with symptom manifestation as reported in the peer-reviewed literature. This study will utilize the Peromyscus eremicus rodent model to elucidate mechanisms of neurotoxicity due to Cu and Mn exposure, individually and combined, using transcriptomic and lipidomic techniques as well as gather samples for a preliminary exposure risk assessment on Cocopah Tribal lands.

PI_NAMEs: CREDO, JONATHAN M (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Adult;Agriculture;Animals;Area;Arizona;Basal Ganglia;Behavioral;Biochemical Reaction;bioinformatics pipeline;Brain;carcinogenicity;Child;Collaborations;Communities;Consumption;Copper;County;Data;Data Set;differential expression;dopaminergic neuron;Elements;Environmental Pollution;Exposure to;Family;farm worker;Fellowship;Funding;Gene Expression;Genes;Genetic;Goals;ground water;Hair;Health;health assessment;Housing;Human;Human Volunteers;improved;Incidence;Individual;Industrialization;insight;ion mobility;Kilogram;landfill;lead exposure;Link;lipid metabolism;lipidomics;Lipids;Liquid Chromatography;Manganese;Mass Spectrum Analysis;Mercury;metabolic profile;Metabolism;metabolomics;Metal exposure;Metals;Mexico;Micronutrients;Migrant;Modality;Modeling;Motor;motor disorder;multidisciplinary;Muscle Contraction;nano-string;Neurologic Effect;neurotoxic;neurotoxicity;Neurotoxins;novel;olfactory bulb;organic base;Organism;Outcome;Output;oxidative damage;Pathway Analysis;Pathway interactions;Peer Review;Peromyscus;Persons;pesticide exposure;Pesticides;Poison;Population;Quantitative Reverse Transcriptase PCR;Reporting;Research;Reservations;response;Review Literature;Risk;Risk Assessment;Rodent;Rodent Model;Sampling;Seasons;Sentinel;Severity of illness;Site;Source;Spectrometry;Symptoms;Techniques;Tissues;toxic metal;Toxin;Training;transcriptomics;tribal lands;tribal member;Tribes;Underserved Population;United States;virtual;wasting;Work

PROJECT_TITLE: Neurological effects of toxic metal exposure in model rodents collected in zones of industrial agriculture on the U.S.-Mexico border


ORG_DEPT: DERMATOLOGY

PHR: Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer caused by a virus. Because we do not know where MCCs arise, it has not been possible to create a mouse model of this cancer. In this grant, we propose to combine viral oncogenes, together with factors that produce Merkel cells, to generate and study MCC tumors in genetically-engineered mice.

PI_NAMEs: DLUGOSZ, ANDRZEJ A. (contact);VERHAEGEN, MONIQUE ELISE

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Adult;Aggressive behavior;Alleles;Antigen Targeting;Antigens;Behavior;Biological;Cancer Etiology;Cancer Model;candidate identification;Cell Line;Cell Lineage;Cell Reprogramming;cell type;Cells;cellular engineering;Collection;Coupled;Development;Doxycycline;epidermal stem cell;experimental study;Genetically Engineered Mouse;Grant;Growth;Human;immunodeficiency;in vivo;inducible Cre;insight;keratinocyte;knock-down;Large T Antigen;loss of function;Maintenance;Malignant Epithelial Cell;Malignant Neoplasms;Merkel cell carcinoma;Merkel Cells;Messenger RNA;Modeling;Molecular;mouse model;Mus;neoplastic cell;Neuroendocrine Cell;neuroendocrine phenotype;Neuroendocrine Tumors;Neurosecretory Systems;novel strategies;Pathogenesis;Phenotype;Play;Polyomavirus;Polyomavirus Transforming Antigens;postmitotic;Pre-Clinical Model;Production;Proliferating;Property;Resistance;Role;Skin;Skin Cancer;Small T Antigen;stem cells;Suspensions;Testing;Touch sensation;TP53 gene;Transcript;transcription factor;transcriptome;transgene expression;Transplantation;tumor;tumor progression;Tumor Stem Cells;tumorigenesis;tumorigenic;Variant;Viral;Viral Oncogene;Virus;Work

PROJECT_TITLE: Cell fate decisions in Merkel cell carcinoma initiation and maintenance

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative: We propose to investigate the role of the macro-vasculature surrounding indeterminate lung nodules depicted on CT images to discriminate screen-detected benign and malignant nodules. The goal is to improve lung cancer screening by reducing the number of unnecessary procedure associate the high rate of false positive detections.

PI_NAMEs: PU, JIANTAO  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Administrator;Adult;Age;Benign;Biological Markers;Biopsy;Blood Vessels;Breast;cancer biomarkers;cancer diagnosis;Cancer Etiology;cancer therapy;Cause of Death;Cessation of life;Characteristics;Chest;chest computed tomography;Classification;Clinical;Clinical Management;Colon;Computational algorithm;computed tomography screening;cost;Data Set;demographics;density;Development;Discrimination;Early Diagnosis;Ensure;Environment;Ethnic Origin;follow-up;Funding;Gender;Goals;Grant;Growth;Image;imaging biomarker;improved;Individual;Institution;Investigation;Lead;longitudinal database;low dose computed tomography;Lung;lung cancer screening;Lung nodule;Machine Learning;Malignant - descriptor;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Modeling;Morphology;mortality;multidisciplinary;Nodule;novel;novel marker;Odds Ratio;Outcome;Output;Participant;Patients;Pattern;Performance;Policies;Policy Maker;Positioning Attribute;Positron-Emission Tomography;Predictive Value;Procedures;Productivity;Property;Protocols documentation;Publishing;pulmonary function;Radiation exposure;radiologist;Recording of previous events;Reporting;Risk Assessment;Role;Sampling;Scanning;screening;Signal Transduction;Smoker;Smoking History;spatial relationship;Spiculate;Statistical Data Interpretation;success;Symptoms;Technology;Testing;Texture;Thoracic Radiography;Time;Tobacco smoking behavior;tumor;Tumor Angiogenesis;tumor growth;United States;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Unnecessary Procedures;Variant;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Macro-vasculature: A Novel Image Biomarker of Lung Cance

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Microbiome;Precision Medicine

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative Immunotherapy with PD-1 blockade has become first line of therapy in lung cancer, the leading cause of cancer deaths in the U.S. The lower airway microbiota affects the inflammatory tone of the lower airways. In this grant, we will uncover microbial signatures that affect the response to immunotherapy in lung cancer.

PI_NAMEs: SEGAL, LEOPOLDO NICOLAS (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: 16S ribosomal RNA sequencing;Affect;Airway Disease;aspirate;Biological Markers;Blood;Blood specimen;Cancer Etiology;Cancer Model;Cells;Cessation of life;Chara;Characteristics;checkpoint inhibition;Clinical;Clinical Trials;Color;Data;design;Disease;Distant;dysbiosis;Early identification;Effectiveness;Eligibility Determination;Etiology;Evaluation;Feces;Flow Cytometry;Grant;gut microbiota;gut-lung axis;IL17 gene;Immune;immune checkpoint;Immune response;Immunity;Immunotherapy;individual response;Inflammation;Inflammatory;innovation;Intervention;Investigation;Link;LoxP-flanked allele;Lung;Lung Adenocarcinoma;lung carcinogenesis;lung microbiota;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;metatranscriptome;metatranscriptomics;Methods;Microbe;microbial;microbial signature;microbiome;microbiome research;microbiota;microbiota profiles;Modeling;Modification;mortality;mouse model;mucosal microbiota;multiple omics;Mus;neoantigens;Newly Diagnosed;Non-Small-Cell Lung Carcinoma;novel;Oral;Outcome;Pathway interactions;Patients;personalized therapeutic;Phenotype;PIK3CG gene;Play;pre-clinical;Pre-Clinical Model;predicting response;Predisposition;Prevalence;Prevotella;primary outcome;programmed cell death ligand 1;programmed cell death protein 1;Progression-Free Survivals;prospective;respiratory microbiota;response;Ribosomal RNA;risk stratification;RNA;Role;rRNA Genes;Sampling;single-cell RNA sequencing;smoking prevalence;stool sample;T cell response;T-Lymphocyte;Taxonomy;Testing;therapy outcome;trait;transcriptome;transcriptome sequencing;transcriptomics;treatment responders;treatment response;tumor;Tumor Burden;Tumor Immunity;tumor microenvironment;Validation;Veillonella

PROJECT_TITLE: Local microbiota signatures of pro-tumor immunity and checkpoint inhibition susceptibility in lung cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Genetics

PHR: PROJECT NARRATIVE We previously demonstrated that subdividing germinal center B cells into three populations reveals distinct epigenetic programs; therefore, we hypothesize that the epigenetic reader BRWD1, which controls B cell lymphopoiesis, is also important for peripheral B cell differentiation. Conditional deletion of Brwd1 in follicular B cells inhibited germinal center initiation, whereas deletion of Brwd1 in germinal center B cells promoted proliferation, prevented differentiation of memory B cells, and collapsed epigenetic differences between germinal center B cell subpopulations. The proposed experiments will determine how BRWD1 controls germinal center B cell differentiation, providing insight into how an epigenetic regulator controls cell fate decisions during the humoral immune response.

PI_NAMEs: WRIGHT, NATHANIEL EDWIN (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Affinity;Antibody Affinity;antigen binding;Antigens;Architecture;Autoimmunity;autoreactive B cell;B cell differentiation;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Binding Sites;Bioinformatics;Cell Differentiation process;Cell Fate Control;Cell Physiology;Cell Proliferation;Cells;Chromatin;Darkness;Data;Development;Enhancers;Epigenetic Process;experimental study;Follicular Dendritic Cells;Genetic Transcription;Helper-Inducer T-Lymphocyte;Histones;Humoral Immunities;Immune response;Immunization;Immunoglobulin Somatic Hypermutation;Immunologic Memory;Infection;insight;Knock-out;Light;Lymphoma;Lymphopoiesis;Maintenance;Malignant - descriptor;Manuscripts;Mature B-Lymphocyte;Measures;Memory;Memory B-Lymphocyte;Microscopy;Modeling;Mus;Peripheral;Plasma Cells;Population;prevent;Process;programs;Proliferating;Publishing;Reaction;Reader;recruit;Regulation;Repression;Research;response;Role;Site;Structure of germinal center of lymph node;T-Lymphocyte;Testing;timeline;Tingible Body Macrophage;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: The role of BRWD1 to establish epigenetic states for germinal center initiation, maintenance, and exit

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-M(20)]


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Understanding and treating neurological diseases is a high priority in the United States and globally. Loss of the brain-specific transfer RNA (tRNA), n-Tr20, can alter neuron function and the severity of genetic forms of neurodegeneration and epilepsy. Our goal is to find the mechanism by which loss of tRNAs cause neurological disease.

PI_NAMEs: ACKERMAN, SUSAN L (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Absence Epilepsy;Acute;Alleles;Amino Acids;Anticodon;Astrocytes;biological adaptation to stress;Brain;Brain region;Buffers;Cell Death;Cell Physiology;cell type;Cells;Chemicals;ChIP-seq;Classification;Codon Nucleotides;Cytoplasm;Data;Development;differential expression;Disease;Epilepsy;Epitopes;Equilibrium;Eukaryota;excitatory neuron;Family;Family member;FRAP1 gene;frontier;Future;Gene Expression;Gene Family;Genes;Genetic;Genetic Transcription;genome-wide;Goals;granule cell;Hippocampus;Homeostasis;Human;Impairment;in vivo;Individual;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;inhibitory neuron;Investigation;Laboratories;Link;Maintenance;mammalian genome;member;Messenger RNA;Microglia;Modeling;Molecular;mouse genome;mouse model;mRNA Translation;mTOR Inhibitor;Mus;Mutation;Nature;Nerve Degeneration;Nervous System Disorder;neuronal cell body;Neurons;novel;Nuclear;null mutation;overexpression;patch clamp;Phenotype;Physiological;Physiology;Predisposition;Process;Property;Proteins;Regulation;response;restoration;Ribosomes;RNA;RNA Polymerase III;Role;Seizures;Severities;Signal Pathway;Signal Transduction;Sirolimus;Small RNA;Synapses;Synaptic Transmission;Synaptosomes;Testing;Tissues;Transcript;transcriptome;Transfer RNA;transgene expression;Transgenic Organisms;Translations;translatome;United States;Variant;Vertebrates;Wild Type Mouse;Work

PROJECT_TITLE: The Function of the Cytoplasmic tRNA Repertoire in the Cellular and Molecular Homeostasis of the Mammalian Brain

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Diabetes;Dietary Supplements;Neurodegenerative;Neurosciences;Nutrition;Pain Research;Peripheral Neuropathy;Prevention

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Peripheral neuropathy (PN) is a major complication affecting about 50% of the diabetes population with symptoms ranging from pain, numbness, paresthesia and ulceration in the extremities it is also the major cause of non-traumatic amputations. Besides pain management the only option physicians have to slow progression of PN is glycemic control but in type 2 diabetes even good glycemic control is ineffective. Our pre- clinical studies have focused on discovery of an effective treatment and have identified the combination of omega-3 polyunsaturated fatty acids (fish oil) and salsalate as a potential candidate, however; before clinical trials can be initiated we need to have a better understanding of the most effective dose of omega-3 polyunsaturated fatty acids and salsalate that will increase the omega-3 index to a healthy level and maximize the formation of pro-resolving metabolites in diabetes subjects with PN.

PI_NAMEs: BUSUI (POP-BUSUI), RODICA ;YOREK, MARK A. (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Affect;Amputation;Anti-Inflammatory Agents;Aspirin;Automobile Driving;Biological Assay;blood glucose regulation;C-reactive protein;chemokine;Chronic;Clinical;Clinical Trials;Complication;Complications of Diabetes Mellitus;cost;cytokine;Data;design;Development;Diabetes Mellitus;diabetic;Diabetic Neuropathies;Disease;Docosahexaenoic Acids;Dose;effective therapy;Effectiveness;efficacious treatment;Eicosapentaenoic Acid;Enzyme-Linked Immunosorbent Assay;Erythrocytes;Fatty Acids;Fish Oils;glycemic control;Goals;Health Care Costs;Healthcare Systems;Human;human subject;improved;In Vitro;in vivo;indexing;Inflammation;Inflammatory;inflammatory marker;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Interleukin-10;Interleukin-6;Iowa;Knowledge;Laboratories;Limb structure;lipid mediator;lipidomics;Liquid Chromatography;Measures;Mediator;Menhaden oil;Metabolic;Michigan;mortality risk;nerve damage;Nerve Regeneration;nerve repair;neurite growth;neuroprotection;Non-Insulin-Dependent Diabetes Mellitus;Numbness;Omega-3 Fatty Acids;Outcome;Oxidative Stress;Pain;Pain management;Paresthesia;Participant;patient population;Patients;Peripheral Nervous System Diseases;personalized approach;Phase II/III Trial;Physical Function;Physicians;Population;pre-clinical;preclinical study;Production;Property;Quality of life;repaired;Research;response;Risk;Risk Factors;Rodent;Safety;Salicylic Acids;salicylsalicylic acid;Series;side effect;success;Sum;Supplementation;Symptoms;tandem mass spectrometry;targeted treatment;Testing;Therapeutic;TNF gene;Translating;Ulcer;Universities;Work

PROJECT_TITLE: Effects of Fish Oil ± Salsalate on the Omega-3 Index and the Circulating Lipodome of Omega-3 Polyunsaturated Fatty Acid Metabolites in Patients with Type 2 Diabetes and Diabetic Neuropathy


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE The project is designed to identify new vulnerabilities for subtypes of advanced prostate cancer that can be exploited to enhance clinical responses and improve outcomes. We will use multiple new models of metastatic prostate cancer that we have developed and characterized to identify specific subtype specific dependencies using pharmacologic and genome-wide loss-of-function screens. Combinations of agents that exploit genomic dependencies will be tested in vivo against a panel of patient derived xenograft (PDX) lines with and without the predicted vulnerability.

PI_NAMEs: NELSON, PETER S (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Address;advanced prostate cancer;Androgen Receptor;Behavior;Benign;Biological;Cancer Biology;Cancer cell line;cancer genome;cancer subtypes;cancer type;Carcinoma;Cell Line;cell type;Cells;Characteristics;Classification;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Data;Data Set;Defect;Dependence;design;Development;Disease;Distant;DNA Sequence Alteration;Drug Screening;drug sensitivity;Encyclopedias;epigenomics;ETS Family Gene;Exclusion;Exhibits;experimental study;Foundations;functional loss;Genes;Genetic;Genetic Screening;genome-wide;genomic data;Genomic Instability;Genomics;Genotype;Growth;Homeostasis;Human;improved outcome;In Vitro;in vivo;in vivo evaluation;insight;International;Knowledge;Libraries;loss of function;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Metastatic Prostate Cancer;Modeling;Molecular;molecular subtypes;Morbidity - disease rate;mortality;Mutation;Neoplasm Metastasis;neoplastic cell;new technology;Normal tissue morphology;novel;novel anticancer drug;novel therapeutics;Oncogenes;Organ;Outcome;Output;Pathway interactions;patient derived xenograft model;Patients;personalized approach;Pharmaceutical Preparations;pharmacologic;Phenotype;precision medicine;prostate cancer cell line;prostate cancer metastasis;prostate cancer model;public repository;Recurrence;Reiterated Genes;Research;Resistance;response;Series;Site;small hairpin RNA;Solid Neoplasm;Technology;The Cancer Genome Atlas;Therapeutic;therapeutic target;Tissues;tool;tumor;tumor growth;tumor heterogeneity;tumor progression;Tumor Subtype;tumorigenesis;United States Food and Drug Administration;Work

PROJECT_TITLE: A Prostate Cancer Dependency Map to Identify Tumor Subtype-Specific Vulnerabilities


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative Changes in DNA methylation and gene expression are hallmarks of acute myeloid leukemia, but mechanisms underlying these changes are poorly understood. We propose to define the genome-wide relationship between DNA hypermethylation and 3D genome architecture using primary AML samples with canonical DNA methylation phenotypes, and to perform detailed mechanistic studies of epigenetic modifications, chromatin interactions, and gene expression at the HOXA locus in primary AML samples and AML cell line models. Together these studies should allow us to better identify genes that are dysregulated by the effects of DNA hypermethylation, and may lead to new approaches for disrupting HOXA-mediated self-renewal in AML cells.

PI_NAMEs: SPENCER, DAVID H (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: 3-Dimensional;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Affect;Architecture;Biological Assay;Cell Line;Cells;Chromatin;CRISPR/Cas technology;Data;data integration;defined contribution;Development;DNA;DNA Integration;DNA Methylation;Enhancers;Epigenetic Process;ETV6 gene;Evolution;Exhibits;Gene Cluster;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Enhancer Element;Genetic Transcription;Genome;genome editing;genome-wide;genome-wide analysis;genomic locus;Genomic Segment;Goals;Hematopoietic;Hematopoietic stem cells;Homeobox Genes;Hypermethylation;Impairment;improved;In Situ;In Vitro;in vivo;Individual;insight;leukemia;Link;Malignant Neoplasms;Mediating;Methylation;methylation pattern;Modeling;Modification;Mus;mutant;Mutation;new therapeutic target;novel strategies;Pathogenesis;Pathway interactions;Pattern;Phenotype;Preleukemia;prevent;promoter;Regulatory Element;Reporter;Role;Sampling;self-renewal;Somatic Mutation;Testing;Therapeutic;transcription factor;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Dysregulated genome architecture in acute myeloid leukemia

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Comparative Effectiveness Research;Emergency Care;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: The Strategies to Innovate Emergency Care Clinical Trials Network (SIREN) will establish a robust and readily accessible infrastructure to conduct clinical trials to identify treatments to advance patient management in the prehospital and emergency department settings. The Data Coordinating Center (DCC) of the Network offers economies of scale that will enable the Network to conduct multiple clinical trials simultaneously and efficiently. This in turn will have an impact on the public health by potentially improving the outcomes of patients with emergency indications related to neurology (e.g. status epilepticus, traumatic brain injury, spinal cord injury), cardiovascular, respiratory, hematology, and trauma.

PI_NAMEs: DURKALSKI, VALERIE L (contact);YEATTS, SHARON DZIUBA

PROGRAM_OFFICER_NAME: SCOTT, GRETCHEN CARLYLE

PROJECT_TERMS: Accident and Emergency department;Ancillary Study;Applications Grants;Attenuated;authority;Body System;Budgets;Cardiac;Cardiovascular system;Caring;Case Report Form;central database;Clinical;Clinical Data;Clinical Investigator;clinical research site;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Collaborations;Communication;Conduct Clinical Trials;confirmatory clinical trial;cost;COVID-19;COVID-19 pandemic;Creativeness;Data;Data Collection;Data Coordinating Center;data integration;data management;data quality;Data Reporting;Data Set;data sharing;data standards;design;Development;Diagnosis;Disease;distributed data;Early Intervention;effective therapy;Effectiveness;Emergency Care;Emergency Department Physician;Emergency research;emergency settings;Emergency Situation;Ensure;Event;expectation;experience;FDA approved;Funding;Goals;Grant;Guidelines;Health Sciences;Hematology;Hospital Departments;improved;improved outcome;Individual;Information Management;Informed Consent;Infrastructure;Injury;innovation;Intensive Care Units;Intervention;Investigation;Manuscripts;Medical;Mission;Monitor;Multicenter Trials;multidisciplinary;Neurologic;Neurological emergencies;Neurologist;Neurology;Neurosurgeon;novel;Online Systems;operation;Outcome;pandemic disease;participant enrollment;patient engagement;Patient-Focused Outcomes;Patients;pragmatic trial;pre-clinical research;Preparation;Principal Investigator;Productivity;protocol development;Public Health;Publications;quality assurance;Quality Control;Regulation;Reporting;Research;Research Design;Research Personnel;Resources;respiratory;response;Resuscitation;Risk;Role;Site;South Carolina;Specific qualifier value;spinal cord and brain injury;Standardization;Status Epilepticus;success;support network;System;tool;Translational Research;Trauma;Traumatic Brain Injury;treatment trial;trial design;trial enrollment;trial planning;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - Data Coordinating Center


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Per- contaminants promising synthesize to as (PFAS) of emerging concern. Few effective soil remediation options are available. Phytoremediation is a  strategy; however, it is not effective for all classes of PFAS. Therefore, we will design and customized novel nanomaterials (carbon dots and ultraporous mesostructured silica nanoparticles) enhance PFAS phytoremediation by hemp plants. Their effectiveness will be tested in a hydroponic system, well as in PFAS-contaminated field soils. and polyfluoroalkyl substances are widespread, environmentally-persistent, highly toxic,

PI_NAMEs: HAYNES, CHRISTY L;VASILIOU, VASILIS  (contact);WHITE, JASON

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Acids;Affinity;aqueous;bioaccumulation;Biological Models;Carbon;Chemicals;Complex;Confocal Microscopy;cost effective;Custom;dashboard;design;drinking water;Effectiveness;efficacy testing;Environment;Excision;Exhibits;experimental study;Exposure to;Fluorine;Food;Fright;Fullerenes;Goals;ground water;Health;Hemp;hydrophilicity;Hydrophobicity;Hydroponics;Image;In Situ;learning materials;Length;Liquid Chromatography;luminescence;Mass Spectrum Analysis;Measures;Methods;microwave electromagnetic radiation;Modification;Movement;nanomaterials;nanoparticle;novel;Nuclear Magnetic Resonance;organic contaminant;particle;perfluorooctane;perfluorooctane sulfonate;perfluorooctanoic acid;Phase;plant growth/development;Plant Roots;Plants;Poly-fluoroalkyl substances;Process;Property;Pump;remediation;Research;Resolution;restoration;scaffold;Silicon Dioxide;Site;Soil;spectroscopic imaging;Spectrum Analysis;Sulfonic Acids;Surface;Surface Properties;System;Techniques;Testing;Time;Tissue imaging;Tissues;Translating;uptake;Variant;Visual;Water;Work

PROJECT_TITLE: Understanding and Enhancing PFAS Phytoremediation Mechanisms Using Novel Nanomaterials


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Data Science;Drug Abuse (NIDA only);Health Services;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: BURNABY

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: SIMON FRASER UNIVERSITY

ORG_STATE: BC

ORG_ZIPCODE: V5A 1S6

PHR: PROJECT NARRATIVE As the public health and economic toll of the opioid epidemic rises, the international community needs rigorous evidence on best practices for the clinical management of people with opioid use disorder. Taking advantage of perhaps the world’s most comprehensive population-level database to study opioid use disorders and applying cutting-edge methods for causal inference, our proposal aims to fill the highest-priority gaps in this evidence base. As expanding access to opioid agonist treatment is a key element in the public health response to the opioid crisis, this proposal directly aligns with the national declaration of a public health emergency on opioid overdose, the US’ National Drug Control Strategy, a number of state- level initiatives as well as NIH/NIDA’s HEALing Communities initiative.

PI_NAMEs: NOSYK, BOHDAN  (contact)

PROGRAM_OFFICER_NAME: HAEGERICH, TAMARA

PROJECT_TERMS: Accident and Emergency department;addiction;Adherence;Admission activity;American;Anti-viral Agents;antiretroviral therapy;Articulation;Big Data;Biometry;British Columbia;Canada;care fragmentation;Caring;Case Mixes;Cessation of life;Chronic;Client;Clinical;Clinical Management;clinical practice;combat;Communities;comorbidity;comparative effectiveness;Complement;Consultations;Data;Data Science;data sharing;Databases;design;Disease;Dose;Drug Controls;Drug Screening;Economics;Elements;Ensure;Epidemic;Epidemiology;evidence base;experience;Fentanyl;fentanyl contamination;flexibility;Florida;Guidelines;healing;Health;Health system;Healthcare Systems;Hepatitis C virus;high dimensionality;HIV Seropositivity;HIV/AIDS;Hospitalization;Illicit Drugs;Imprisonment;improved;Income;Individual;Influentials;integrated care;International;International AIDS;Level of Evidence;Link;Measures;Medical;Medicine;Mental Health;Methadone;Methodology;Methods;Michigan;mortality;National Institute of Drug Abuse;New Jersey;Ohio;opioid agonist therapy;opioid epidemic;opioid overdose;opioid use disorder;Outcome;overdose death;Pain;patient subsets;Pennsylvania;Performance;Perinatal Care;Persons;Pharmaceutical Preparations;Physicians;Policy Maker;Population;Positioning Attribute;Probability;Protocols documentation;Province;Public Health;public health emergency;Recommendation;Recording of previous events;Records;Regimen;Relapse;Reporting;Research;response;Rhode Island;Safety;screening;Series;social factors;Societies;Specific qualifier value;Standardization;structural determinants;Structural Models;Suboxone;synergism;synthetic opioid;Testing;theories;therapy adherence;tool;treatment effect;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Update;uptake;Urine;US State;West Virginia;Work

PROJECT_TITLE: DAT-Emulating target trials with big data to strengthen the evidence base for the clinical management of opioid use disorder

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Microbiome;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE Squamous cell head and neck cancer (SCHNC) is a dreadful disease with significant physical disfigurement and poor survival rates. In this large prospective study, we will test the hypothesis that oral (fungal) mycobiome influences SCHNC development, potentially related to alcohol and tobacco carcinogen metabolism. Knowledge gained from this study will increase our understanding of the etiology of SCHNC, help to identify high-risk subjects, and may lead to new approaches for prevention of this disease.

PI_NAMEs: AHN, JIYOUNG ;HAYES, RICHARD BERNARD (contact)

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acetaldehyde;Address;aerodigestive squamous cell carcinomas;African American population;alcohol effect;Alcohols;Animal Model;Bacteria;Cancer Prevention Study II;cancer risk;Candida;Candidiasis;Carcinogen Metabolism;carcinogenicity;Carcinogens;Cessation of life;Clinical;cohort;Cohort Studies;Communities;Corynebacterium;Data;Development;Diagnostic;Disease;disorder prevention;DNA sequencing;Etiology;Exposure to;fungus;General Population;Genes;Genetic Diseases;Genetic Transcription;Goals;head and neck cancer patient;head and neck cancer prevention;Head and Neck Squamous Cell Carcinoma;high risk;Human;Human Papillomavirus;improved;individualized prevention;Infection;Inflammation;innovation;Knowledge;Larynx;malignant mouth neoplasm;Mediating;Metabolic Pathway;metagenome;microbial;microbiome sequencing;microbiota;Minority;Modality;mortality;mycobiome;Nested Case-Control Study;Nitrosamines;novel;novel strategies;Oral;oral bacteria;oral carcinogenesis;Oral cavity;oral fungal;oral microbial community;oral microbiome;oral premalignancy;Participant;pathogenic fungus;Pathway interactions;Patients;personalized approach;Persons;Pharyngeal structure;polymicrobial biofilm;Population;Prevalence;prophylactic;Prospective Studies;Quality of life;racial diversity;Risk;Risk Factors;Sample Size;Shotgun Sequencing;Smoking;study population;Survival Rate;Taxonomy;Testing;Tobacco;Tobacco-Associated Carcinogen;Tumor Tissue

PROJECT_TITLE: The Oral Microbiome and Upper Aerodigestive Squamous Cell Cancer

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: NARRATIVE Despite the encouraging results, a minority of cancer patients still benefit from immune checkpoint inhibition therapies, with many exhibiting primary or acquired resistance. Tumor cells have been shown to truncate or mutate 3' untranslated regions (3'UTRs) of coding genes, important regions for post-transcriptional control of gene expression, in order to bypass regulatory mechanisms and escape surveillance by the immune system. We will use comprehensive experimental and computational technologies to characterize the effects of 3'UTR mutations and truncations on the tumor immune landscape, across 33 tumor types; enabling a thorough understanding of regulatory mechanisms in cancer, as well as uncovering a novel class of markers for patient stratification or targets for immunotherapeutics.

PI_NAMEs: VLACHOS, IOANNIS  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: 3' Untranslated Regions;3-Dimensional;adaptive immunity;Affect;Alleles;Bioinformatics;Biological Assay;Biological Markers;Biomimetics;brca gene;Bypass;cancer immunotherapy;Cancer Patient;cancer type;Cell Fraction;cell killing;Cells;checkpoint inhibition;Clinical;Coculture Techniques;Code;cohort;Data;Data Set;deep learning model;Detection;Development;Devices;Disease;Epigenetic Process;ERBB2 gene;Evaluation;Event;Exhibits;exome;Gene Expression;Gene Expression Regulation;Genes;genome sequencing;genomic data;Hematoxylin and Eosin Staining Method;Image;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune system;Immunologic Surveillance;Immunooncology;Immunophenotyping;immunoregulation;Immunotherapeutic agent;Immunotherapy;in silico;In Situ;In Vitro;innovation;Investigation;Light;Malignant Breast Neoplasm;Malignant Neoplasms;Massive Parallel Sequencing;Mediating;Messenger RNA;Methods;Microfluidic Microchips;MicroRNAs;Minority;Molecular;multimodal data;Multiomic Data;Mutate;Mutation;Natural Immunity;Neoplasm Metastasis;neoplastic;neoplastic cell;new therapeutic target;novel;Nucleic Acid Regulatory Sequences;Oncogenes;Oncogenic;Outcome;Pathology;Pathway interactions;patient stratification;Patients;Phenotype;Polyadenylation;Post-Transcriptional Regulation;posttranscriptional;predicting response;Process;Quantitative Trait Loci;Regulation;Research;Research Personnel;Resistance;Resources;response;RNA Editing;RNA-Binding Proteins;Role;Sampling;Somatic Mutation;statistical learning;T-Lymphocyte;Technology;The Cancer Genome Atlas;therapeutic target;Time;transcriptome;transcriptome sequencing;transcriptomics;translational potential;Translations;treatment response;tumor;Tumor Escape;tumor immunology;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Untranslated RNA;Validation;Variant

PROJECT_TITLE: Pan-Cancer characterization of 3’UTR somatic mutations controlling tumor immune evasion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: This project will update and expand MIRDcell, a software tool for dosimetry and radiobiology for radiopharmaceutical therapy. The present version MIRDcell v2.1 is powerful, yet has limitations that restrict  its use to education and basic science. The work proposed herein will create MIRDcell v3 with expanded capabilities that accommodate patient specific treatment planning for radiopharmaceutical therapies directed against disseminated tumor cells and micrometastases.

PI_NAMEs: HOWELL, ROGER W. (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: 3-Dimensional;absorption;Address;Adverse effects;Advocate;Affect;Algorithms;Alpha Particles;Basic Science;Beta Particle;Biological;Bystander Effect;cancer cell;cancer therapy;Cell Compartmentation;cell killing;Cell membrane;Cell Nucleus;cell type;Cells;Classification;Clinic;Code;Collaborations;Collection;Custom;Cytoplasm;Data;design;Development Plans;Dimensions;Disease;Distributional Activity;Dose;Dose Rate;dosimetry;Education;Elements;External Beam Radiation Therapy;Fibroblasts;flexibility;Future;High-LET Radiation;Image;improved;individualized medicine;innovation;intercellular communication;interest;Label;Learning;Lutetium;Malignant Neoplasms;Micrometastasis;Microscopic;Modeling;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;Output;particle;Photons;predicting response;Primary Neoplasm;Probability;Radiation;Radiation Tolerance;Radioactivity;Radiobiology;Radioisotopes;Radiopharmaceuticals;Radium;Relative Biological Effectiveness;Research;response;Schedule;Slice;Software Tools;Specific qualifier value;Speed;Students;success;Surface;Testing;Therapeutic Effect;therapy design;Tissues;Tomogram;tool;Treatment Efficacy;treatment planning;tumor;United States Food and Drug Administration;Update;uptake;usability;Visual;Work

PROJECT_TITLE: MIRDcell Version 3

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The research described in this proposal will investigate the effect of the exercise-induced, liver-derived blood factor Gpld1 on the brain vasculature, as a critical mediator in combating functional drivers of brain aging. This study will delineate cellular and molecular mechanisms underlying the rejuvenating effects of systemic Gpld1 on cognitive function in the aged hippocampus. The results from this study will have significant translational potential, positing Gpld1 as a novel therapeutic target to reverse vascular and cognitive impairments in brain aging and age-related neurodegenerative diseases such as Alzheimer’s disease.

PI_NAMEs: BIERI, GREGOR  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Adult;Age;age related;age related neurodegeneration;Age-associated memory impairment;aged;Aging;aging brain;aging hippocampus;aging population;aging related;Alzheimer's Disease;animal old age;arm;Automobile Driving;Blood;Blood Vessels;Brain;brain dysfunction;brain parenchyma;Cardiovascular system;Cell Nucleus;Cell Surface Proteins;cellular targeting;Cerebrovascular system;Cognition;Cognitive;cognitive function;Confocal Microscopy;Data;Degenerative Disorder;dementia burden;Disease;Elderly;Endothelial Cells;Enzymes;Exercise;fitness;Glycosylphosphatidylinositols;GPI Membrane Anchors;hippocampal atrophy;Hippocampus;Human;Immunohistochemistry;Impaired cognition;Impairment;improved;inhibitor;interest;juvenile animal;Label;Learning;Liver;Measures;Mediator;Memory;Molecular;Molecular Target;mouse model;Mus;Neurodegenerative Disorders;new therapeutic target;novel;novel therapeutics;object recognition;old mice;Parabiosis;Patients;Permeability;phospholipase D1;Phosphoric Monoester Hydrolases;Physical Exercise;Plasma;Plasma Proteins;Predisposition;Proteins;Proteolysis;Radial;Rejuvenation;Research;Role;single nucleus RNA-sequencing;spatial memory;systemic intervention;Testing;theories;Therapeutic;Tracer;transcytosis;translational potential;Vascular Cognitive Impairment;Vascular Diseases;water maze

PROJECT_TITLE: Investigating the role of the exercise blood factor Gpld1 in restoring brain vasculature function and cognition in aging


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Cancer;Digestive Diseases;Nanotechnology;Orphan Drug;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE  Desmoplasia reduction using polymeric NPs containing Hh inhibitor MDB5 will effectively deliver EGFR- targeting NPs containing MEK and AKT targeting ONC201 and chemotherapeutic drug gemcitabine (GEM) to the tumor site, hence treat pancreatic cancer with reduced systemic and organ toxicity.

PI_NAMEs: MAHATO, RAM I. (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Abraxane;Adopted;Apoptosis;Apoptosis Inhibitor;BCL2 gene;Binding;Biodistribution;Biological;biological adaptation to stress;Blood Vessels;cancer cell;cancer stem cell;cancer therapy;Carbonates;carcinogenesis;Cell Death;Cells;Chemoresistance;chemotherapy;Clinical;Clinical Trials;combinatorial;Combined Modality Therapy;cost;Cyclin D1;density;Desmoplastic;Development;Dodecanol;Dose Limiting;Down-Regulation;Drug Delivery Systems;Drug Formulations;Drug Kinetics;Encapsulated;Epidermal Growth Factor Receptor;Epithelium;Erinaceidae;ethylene glycol;Extracellular Matrix;Extracellular Signal Regulated Kinases;Failure;Family member;Feedback;Formulation;FRAP1 gene;gemcitabine;Genes;Glutathione;Glycolysis;Goals;Hepatotoxicity;improved;In Vitro;in vivo;Incubated;Inhibition of Cell Proliferation;inhibitor;innovation;Intervention;KPC model;KRAS2 gene;Laboratories;Ligands;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;MEK inhibition;MEKs;Mesenchymal;Metabolism;mouse model;Mus;mutant;Mutate;Mutation;nanomedicine;nanoparticulate;Neoplasm Metastasis;novel;novel strategies;novel therapeutics;Oncogenic;Organ;overexpression;Oxidation-Reduction;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;pancreatic stellate cell;Pathway interactions;Peptides;Pharmaceutical Preparations;Phosphatidylinositols;Phosphorylation;Phosphotransferases;PI3K/AKT;PIK3CG gene;Play;Polymers;Proliferating;propylene;Proteins;Proto-Oncogene Proteins c-akt;Ras/Raf;Reporting;Resistance;resistance mechanism;Role;SHH gene;side effect;Signal Transduction;Site;stem cell biomarkers;stem cell proliferation;Surface;Survival Rate;synergism;Therapeutic;therapeutic evaluation;therapy development;TNF-related apoptosis-inducing ligand;TNFRSF10A gene;TNFRSF10B gene;Toxic effect;Treatment Efficacy;treatment strategy;tumor;Tumor Burden;tumor growth;Tumor Promotion;uptake

PROJECT_TITLE: Nanomedicine of Hedgehog and AKT/ERK Dual Inhibitors for Pancreatic Cancer

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Prostate cancer is the most common and second most lethal malignancy in U.S. men, and better tools are needed to monitor disease and guide therapy. We propose to combine analysis of liquid biopsies (peripheral blood samples) with quantified evaluation of CT scans to monitor disease over time in a phase 3 multi-center clinical trial for men with metastatic prostate cancer. By integrating these modalities and the data we generate from them in a large prospective cohort, we will develop and validate new minimally invasive signatures of disease response and resistance that predict survival and can be used to monitor and optimize treatment in real time.

PI_NAMEs: DUDDALWAR, VINAY ;GOLDKORN, AMIR  (contact);TRICHE, TIMOTHY J.

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Abdomen;Address;advanced disease;Biological;Biological Assay;Biology;Biopsy;Biopsy Specimen;Blood;Blood specimen;Cancer Etiology;Castrate sensitive prostate cancer;Cells;Cessation of life;Clinical;Clinical Investigator;Clinical Management;cohort;Collaborations;Collection;cost;cost effective;Data;Data Analyses;Development;Diagnosis;Disease;Disease Progression;Evaluation;Evolution;Genes;genomic biomarker;Genomics;Goals;Image;image processing;imaging biomarker;improved;Individual;insight;Letters;Life;liquid biopsy;Machine Learning;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Measures;men;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Methods;minimally invasive;Modality;Modeling;Molecular;Molecular Profiling;Monitor;Multi-Institutional Clinical Trial;multidisciplinary;Neoplasm Circulating Cells;Newly Diagnosed;novel;novel therapeutics;Nucleic Acids;Oncology;Outcome;participant enrollment;Pathway interactions;Patients;Pelvis;peripheral blood;Phase;phase III trial;phenomics;Phenotype;Plasma;Plasma Cells;Population;predicting response;predictive modeling;predictive signature;predictive tools;Primary Neoplasm;prognostic signature;prognostic tool;Progression-Free Survivals;prospective;Prospective cohort;Protocols documentation;Radiation Oncology;radiological imaging;radiomics;Randomized;Research Personnel;Resistance;response;Retrieval;RNA;sample collection;Sampling;Scanning;Screening for Prostate Cancer;Site;survival prediction;Synaptophysin;Systemic Therapy;targeted sequencing;Techniques;Testing;Therapeutic Trials;therapy resistant;Time;Tissues;tool;treatment optimization;tumor;Work;X-Ray Computed Tomography

PROJECT_TITLE: Integrated radiomic and liquid biopsy monitoring in SWOG S1802: A phase 3 therapeutic trial for metastatic prostate cancer


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Precision Medicine;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Narrative Immune checkpoint blockade (ICB) has yielded promising results in patients with triple-negative breast cancer (TNBC), but only a subset of patients respond and no predictive biomarker has yet been identified. A replication stress response defect (RSRD) signature has been identified as a potential biomarker that predicts ICB responsiveness in TNBC; the proposed work seeks to understand mechanistically how this biomarker predicts response. The results of the proposed research will help to identify TNBC patients likely to be helped by ICB treatment and to provide effective combination therapies to expand the treatable population.

PI_NAMEs: LIN, SHIAW-YIH  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Achievement;Affect;Bioinformatics;biological adaptation to stress;Biological Markers;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Cancer Burden;Cells;checkpoint therapy;cohort;Combined Modality Therapy;Consensus;CRISPR screen;cytokine;Cytometry;Cytoplasm;Cytotoxic Chemotherapy;Defect;Disease;DNA;DNA biosynthesis;Effectiveness;Enzymes;Exhibits;follow-up;genetic signature;Genetic Transcription;genome integrity;immune checkpoint blockade;immunogenic;immunogenicity;Immunologic Sensitization;Immunological Models;Immunotherapy;improved;improved outcome;in vivo;knock-down;Literature;Mediating;mouse model;multiplexed imaging;Mus;Mutation;neoplastic cell;Normal Cell;novel;Outcome;overexpression;patient prognosis;patient subsets;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Population;potential biomarker;predicting response;predictive marker;Predisposition;Production;Proliferating;Recurrence;replication stress;Replication-Associated Process;Research;Resistance;response;Single-Stranded DNA;System;Testing;Therapeutic Effect;therapy outcome;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Burden;tumor microenvironment;tumor-immune system interactions;Work

PROJECT_TITLE: Replication stress response defects predict and enhance immune checkpoint therapy response in triple negative breast cancer


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PHS Relevance Statement. The determination of three-dimensional protein structures is essential for revealing molecular mechanism of disease processes, and also for structure-based drug design. Concomitantly, technological advances in protein design could revolutionize therapeutic treatment. With these advances, proteins and other molecules can be designed to act on today’s undruggable proteins or tomorrow’s drug-resistant diseases. The proposed computational and experimental studies of protein structures, dynamics, and design methodology will illuminate targets of biochemical and pharmacological significance, and the design of new therapeutics can alleviate mortality, morbidity, and human suffering.

PI_NAMEs: DONALD, BRUCE R. (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 3-Dimensional;Algorithm Design;Algorithms;Antibodies;Antigens;Area;Binding;Biochemical;Biological;biophysical properties;Combinatorial Optimization;Computational Geometry;Computer Models;Computer software;computer studies;Computing Methodologies;data modeling;design;Disease;Disease Resistance;drug candidate;Drug Design;Drug resistance;Drug Targeting;experimental study;Future;Generations;Goals;Human;improved;In Vitro;in vivo;inhibitor;Investigation;Machine Learning;Measurement;Measures;Methodology;Methods;Modeling;Molecular;Molecular Biology;Morbidity - disease rate;mortality;Mutation;neutralizing antibody;new therapeutic target;novel;novel therapeutics;open source;pharmacologic;Probability;Process;Program Sustainability;Protein Dynamics;Protein Engineering;protein protein interaction;protein structure;Proteins;Research;Research Project Grants;resilience;Resistance;resistance mutation;response;Structure;System;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;Viral Antibodies

PROJECT_TITLE: Computational and Experimental Studies of Protein Structure and Design

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]