ADMINISTERING_IC: MH

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative The proposed study will address a critical health care disparity by adapting an evidence-based suicide risk detection and management program, the NIMH Clinical Pathway, to be delivered in the rural Appalachian school-based health care setting. Implementation strategies, materials, and data from this project will be used to facilitate the widespread adoption and evaluation of the pathway as a routine suicide risk detection management program across rural Appalachia. This addresses the critical need for effective and sustainable suicide prevention programs for this high-risk, underserved population.

PI_NAMEs: CHRISTENSEN, MARY  (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: acute care;Address;Adoption;Age;Appalachian Region;barrier to care;Behavior;Belief;care seeking;Caring;Cause of Death;Clinic;Clinical Pathways;Communities;Data;depressive symptoms;design;Detection;distrust;Effectiveness;effectiveness/implementation hybrid;Evaluation;evidence base;experience;Feeling suicidal;Firearms;follow-up;Future;Geography;Goals;health care availability;health care disparity;health care settings;Health Personnel;help-seeking behavior;high risk;implementation barriers;implementation facilitators;implementation strategy;improved;innovation;Intervention;Medical;Mental Depression;Mental Health;Mental Health Services;Methods;National Institute of Mental Health;Pathway interactions;Patient-Focused Outcomes;Phase;Pilot Projects;Prevention program;programs;Provider;Randomized, Controlled Trials;Reduce health disparities;Research Design;Resources;Risk;Rural;Rural Appalachia;Safety;school based health center;Schools;screening;self reliance;Services;Site;social stigma;Stigmatization;Strategic Planning;structural determinants;suicidal;suicidal risk;Suicide;Suicide prevention;suicide rate;Training;Trauma;treatment as usual;Underserved Population;uptake;Urban Health;Visit;Youth

PROJECT_TITLE: Implementing the NIMH Clinical Pathway in Rural Appalachian School-Based Health Clinics

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Depression;Genetics;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness;Sleep Research

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PUBLIC HEALTH RELEVANCE Circadian rhythm and sleep disruptions are central to major psychiatric diseases like major depression, bipolar disorder, and schizophrenia. Better understanding of how rhythms are altered in these diseases will facilitate design of targeted treatments to realign or amplify disrupted rhythms. Synchronization of these rhythms may prevent the precipitation of manic, depressive, or psychotic episodes and help in overall mood stabilization.

PI_NAMEs: MCCLUNG, COLLEEN A (contact);SENEY, MARIANNE L

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Anhedonia;Anterior;Autopsy;Behavior;Behavioral;Bipolar Disorder;Brain;Brain region;Brain-Derived Neurotrophic Factor;cell type;Cells;cingulate cortex;circadian;circadian pacemaker;Circadian Rhythms;Clinical;clinical diagnosis;cognitive function;cohort;Complement;Corpus striatum structure;Data;Decision Making;depressive symptoms;design;Diagnosis;differential expression;Disease;Diurnal Rhythm;Drops;Electrophysiology (science);endophenotype;Functional disorder;Funding;Gene Expression;Genes;Human;Impulsivity;Individual;insight;knock-down;Major Depressive Disorder;Manic;Measures;Mental disorders;Methods;Mitochondria;Molecular;molecular clock;Moods;Motivation;Motor Cortex;mouse model;Mus;Neurons;neuropsychiatry;Nucleus Accumbens;Pattern;Periodicity;Phase;Precipitation;prevent;Production;Psychiatry;Psychoses;psychotic;public health relevance;putamen;Regulation;Rewards;Role;Sampling;Schizophrenia;Seasons;single cell analysis;single nucleus RNA-sequencing;Sleep;Sleep disturbances;Small Nucleolar RNA;Specificity;substance use;Suicide;Testing;Tissues;Transcript;transcriptome sequencing;Untranslated RNA;Virus;Work

PROJECT_TITLE: Identification of molecular rhythm changes in postmortem tissue from individuals with psychiatric illness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-N (02)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Primary Health Care;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Postpartum depression impacts 1 in 8 women with a live birth and has well-documented negative effects on maternal and infant health. In this K01, Dr. Gordon will evaluate how postpartum Medicaid policies affect screening, diagnosis, and treatment for postpartum depression among low-income mothers in the postpartum year, contributing timely and policy-relevant evidence to reduce income-based disparities in maternal mental health. Dr. Gordon’s mentorship team and training in the delivery of mental health services, mixed-methods research, qualitative methods, and tools to measure and map area-level variation in policy effects will support her goal of becoming an independent mental health services researcher focusing on access to mental health care among low-income populations.

PI_NAMEs: GORDON, SARAH HALL (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Affect;Area;Birth Certificates;Boston;Caring;Cluster Analysis;Continuity of Patient Care;County;Data;Data Analyses;Data Collection;Databases;Depression screen;design;Detection;Diagnosis;Disparity;Enrollment;experience;Focus Groups;Goals;improved;Income;Individual;Infant Health;informant;Interview;Link;Live Birth;Low income;Low Income Population;Maps;Maternal Health;maternal morbidity;Measures;Medicaid;Medicaid eligibility;Mental Health;Mental Health Services;Mentorship;Methods;mortality;Mothers;multilevel analysis;multiple data sources;National Institute of Mental Health;novel;Patients;Pattern;perinatal period;Phase;Policies;Postpartum Depression;Postpartum Period;Pregnancy;professor;Provider;Public Health;Public Health Schools;Qualitative Methods;Research;Research Methodology;Research Personnel;Research Priority;Sampling;screening;Services;skill acquisition;skills;Strategic Planning;Structure;Symptoms;Techniques;tool;Training;Underserved Population;Universities;Variant;Well Child Visits;Woman;women's outcomes

PROJECT_TITLE: The Effects of Postpartum Medicaid Policies on Postpartum Depression Care Among Low-Income Women


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Neurosciences;Pediatric;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The Understanding Neurocognition in Youth with Type 1 Diabetes (UNYT1D) multi-institution clinical consortium will develop and implement a uniform protocol to investigate the neurocognitive impact of new onset type 1 diabetes (T1D) in pre-pubertal children. Our Biostatistics Research Center for UNYT1D will provide scientific leadership for the consortium and consortium-wide infrastructure related to stakeholder engagement, data management and sharing, study design and statistical analysis, and governance and coordination of consortium activities. By combining these activities into a single hub, the BRC will promote rigorous and reproducible research across the consortium and help UNYT1D achieve its scientific objectives.

PI_NAMEs: EBERLY, LYNN E;HELGESON, ERIKA S. (contact)

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: 20 year old;Adherence;Area;Attention;Biological;Biometry;blood glucose regulation;Caregivers;Child;Childhood;Chronic Disease;Clinical;clinical center;Clinical Management;Clinical Research;cohort;Collection;Communication;Complex;Confidentiality of Patient Information;critical period;Data;data acquisition;Data Analyses;Data Collection;data dissemination;Data Element;Data Files;data harmonization;data management;Data Management Resources;data quality;data resource;data sharing;data standards;Dedications;design;Development;Devices;diabetes management;Diabetes Mellitus;Diabetic Ketoacidosis;Diagnosis;Distress;Ensure;experience;follow-up;Fostering;Functional disorder;Glucose;glucose monitor;gray matter;Health;Hyperglycemia;Infrastructure;innovation;Institution;instrument;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;International;Intervention;Laboratories;late life;Leadership;Learning;Longitudinal cohort study;Longitudinal Studies;Machine Learning;Measures;Memory;Mental Health;Methods;Minnesota;Monitor;Motor Skills;Multi-site clinical study;Multicenter Studies;National Institute of Diabetes and Digestive and Kidney Diseases;Neurocognition;Neurocognitive;neuroimaging;novel strategies;Participant;patient population;Play;prepuberty;Prevalence;prevent;Prevention;Process;programs;Protocols documentation;Psyche structure;Qualifying;quality assurance;Quality Control;Recording of previous events;Reporting;Reproducibility;Research;Research Design;Research Infrastructure;Research Personnel;risk mitigation;Role;Safety;Sample Size;Sampling;Site;Sleep;sound;Speed;Standardization;Statistical Data Interpretation;Statistical Methods;success;System;Testing;Time;Training;Universities;visual motor;white matter;Work;Youth

PROJECT_TITLE: Understanding Neurocognition in Youth with Type 1 Diabetes (UNYT1D) Biostatistics Research Center (BRC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-1 (M3)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE Cancer progression is heavily influenced by supportive cells in the tumor microenvironment. The project aims to investigate the previously unknown connection between TREM1-positive leukemia-associated macrophages (LAMs) and leukemogenesis. If successfully completed, the project would uncover novel roles of TREM1 in LAM- leukemia interaction during leukemia development, and yield valuable information on whether targeting TREM1 or its signaling components may be therapeutically useful in the prevention and treatment of leukemia.

PI_NAMEs: DU, WEI  (contact)

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Ablation;Acute Myelocytic Leukemia;Alleles;anti-PD-L1;Blocking Antibodies;Bone Marrow;Bone marrow failure;cancer type;Cells;Complex;CRISPR/Cas technology;Development;DNA Damage;Dysmyelopoietic Syndromes;Engineering;Engraftment;Fanconi's Anemia;Genes;Genetic Diseases;genetic signature;Goals;Hematologic Neoplasms;Human;Immune response;Immunologic Receptors;immunoregulation;Immunotherapeutic agent;Immunotherapy;Infiltration;Inflammation;Inflammatory Response;Knockout Mice;leukemia;leukemia treatment;Leukemic Cell;leukemic stem cell;leukemogenesis;Link;Macrophage;Macrophage Activation;Malignant Neoplasms;Mediating;migration;MLL-AF9;Modeling;Molecular;mouse model;Mus;novel;Oncogenic;Pathologic;Pathologic Processes;patient derived xenograft model;Patients;PD-L1 blockade;Physiological Processes;Play;Preleukemia;prevent;Prevention;programmed cell death ligand 1;Resistance;Role;Signal Transduction;Solid;Stress;Tamoxifen;Therapeutic;Therapeutic Intervention;Tissues;tumor;tumor microenvironment;tumor progression;Tumor Tissue;Tumor-associated macrophages;tumorigenic;Up-Regulation

PROJECT_TITLE: Role of LAM-specific TREM1 in leukemogenesis

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The Elevating Indigenous Wellbeing through Assets-Based Prevention Science (ELEVATE) Training Program seeks to address significant health inequities in premature mortality faced by Indigenous communities by equipping a new generation of scholars with specialized training in prevention science and health equity research. The ELEVATE program addresses key gaps in funding and training for Indigenous health and is aligned with NIH priorities related to addressing health disparities and building a robust and diverse public health scientific workforce. By focusing on the key mental and behavioral health drivers of early mortality, such as suicide and drug- and alcohol-related deaths, this initiative aims to nurture Indigenous and other diverse leadership in scientific research and shape a healthier future for these communities.

PI_NAMEs: HAROZ, EMILY  (contact);WALLS, MELISSA L.

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-N (51)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hearing Loss;Neurosciences;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Hearing loss affects over 40 million adults in the United States and can negatively impact many areas of life for adults. The lack of access to diagnostic hearing tests prevents timely diagnosis and treatment of hearing loss, especially, among adults who live in rural areas. This study will (1) evaluate the experiences and challenges in obtaining hearing tests among adults who live in rural areas and are patients at rural health clinics, and (2) develop a program, in partnership with rural patients and medical providers, which can help rural adults get easier access to hearing tests.

PI_NAMEs: BUSH, MATTHEW LEE (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Administrator;Adult;Advisory Committees;Affect;Appalachian Region;Area;barrier to care;care delivery;Certification;Chronic;Communication impairment;Communities;community advisory board;Community Health;Community Healthcare;Country;County;Depressed mood;Development;Diagnosis;Diagnostic;Disease;Education;Employment;Enabling Factors;Enrollment;Environmental Risk Factor;Epidemiology;Evaluation;experience;Face;Geographic state;Goals;Health;health assessment;health care availability;health care delivery;health care service;health care service utilization;Health Personnel;Health Resources;Health Services Accessibility;Healthcare;Healthcare promotion;Healthcare Systems;Hearing;hearing impairment;hearing loss treatment;Hearing Tests;improved;innovation;Intervention;Kentucky;Life;Measurable;Medical;Medical Economics;medical specialties;medically underserved;Methods;Morbidity - disease rate;mortality;novel;Occupational;older adult;Outcome;patient navigation;Patients;Phase;pilot test;Population;Positioning Attribute;practice-based research network;Precede-Proceed Model;Predisposing Factor;preference;Prevalence;prevent;Prevention;Primary Care;primary care practice;primary care services;programs;Protocols documentation;Provider;Public Health;Reinforcing Factor;Research;Resources;Rural;Rural Appalachia;rural area;Rural Community;rural health clinic;rural healthcare;rural patients;rural underserved;screening;social;therapy development;treatment comparison;underserved community;United States;urban setting;virtual;Vulnerable Populations;Well in self;young adult

PROJECT_TITLE: Hearing Healthcare Assessment in Rural Communities (HHARC)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Social Determinants of Health;Women's Health Research

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE This research addresses a conundrum: Why do twice as many boys as girls receive services to treat Developmental Language Disorder when community samples reveal gender parity in the prevalence of the condition? This research will advance public health by determining the extent to which gender-specific patterns of compensation or disability on the part of the children or gender bias on the part of parents and professionals contribute to the treatment disparity. Either outcome holds direct implications for refining the tools and processes used to diagnose and treat DLD and the polices by which we distribute limited clinical resources.

PI_NAMEs: MCGREGOR, KARLA  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: access disparities;Address;Adult;Affect;Area;Behavior;Belief;boys;Caregivers;Child;Child Language;Clinical;clinical practice;Communities;community research;Compensation;Data;data mining;Databases;design;Diagnosis;disability;disabled;Disabling;Disparity;Education;expectation;Family;Focus Groups;Gender;gender difference;girls;Goals;Health;health care availability;help-seeking behavior;Impairment;improved;Inequity;Institution;interest;Interview;Language;Language Development;Language Development Disorders;Language disability;language impairment;Laws;Masks;Measures;Methods;Mission;Modeling;National Institute on Deafness and Other Communication Disorders;Only Child;Outcome;Parents;parity;Pathologist;Pattern;Phase;Police;Policies;Prevalence;Process;Public Health;Reading;Records;Research;Research Personnel;Resources;Role;Sampling;Schools;service delivery;service gap;Services;Sex Bias;Sex Differences;skills;social;Specialist;Speech;Strategic Planning;Surveys;System;teacher;Temperament;Testing;tool;treatment disparity;United States National Institutes of Health;Women's Health

PROJECT_TITLE: Sex and Gender Differences in Language Impairment, Disability, and Service Receipt

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative This proposal seeks to contribute to a consortium of studies that will generate new knowledge on the physiological drivers of type 2 diabetes subtypes by providing an expert team and an extensive array of data from existing studies. We will use hard-clustering and soft-clustering statistical methods coupled with phenotypic, genotypic, and metabolomic data to develop a framework for identifying reproducible and physiologically driven subtypes of type 2 diabetes. We believe that this information will be used by clinicians and patients to better guide type 2 diabetes prevention and treatment strategies.

PI_NAMEs: ALLRED, NICHOLETTE D.;BANCKS, MICHAEL PATRICK (contact);HSU, FANG-CHI

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Adult;adverse outcome;African American;Age;American;Asian;Atherosclerosis;Atherosclerosis Risk in Communities;Beta Cell;Biochemical;Biochemical Markers;Biochemical Pathway;Biological Assay;Biometry;Black race;Blood specimen;cardiovascular disorder risk;Caring;Cell Physiology;Cerebrovascular Disorders;Chronic Kidney Failure;Classification;Clinical;clinical care;clinical phenotype;clinical risk;cohort;Collaborations;Collection;Complications of Diabetes Mellitus;Computing Methodologies;Coronary Artery Risk Development in Young Adults Study;Coronary heart disease;Coupled;Data;Data Coordinating Center;data integration;Data Science;Development;Diabetes Mellitus;Disease;Disease Outcome;Disease Progression;diverse data;Enrollment;Epidemiology;ethnic diversity;Ethnic Population;Etiology;Family Study;Female;Freezing;Functional disorder;Genetic;Genetic Predisposition to Disease;Genomics;Genotype;Goals;Health;health data;Heart;Heart failure;Heterogeneity;Hispanic;Hispanic Community Health Study;Hispanic Community Health Study/Study of Latinos;improved;Individual;Insulin deficiency;Insulin Resistance;Intervention;Knowledge;Life Style;metabolomics;Methodology;Methods;Modeling;mortality;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;multidisciplinary;multiple data types;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Patients;Pattern;Pharmacologic Substance;Phenotype;Physiological;Physiological Processes;Physiology;Population;Populations at Risk;Positioning Attribute;precision medicine;Prediabetes syndrome;Prevention;Prevention strategy;Process;prospective;Race;Randomized, Controlled Trials;Reproducibility;Research;response;Retinal Diseases;Risk;risk minimization;Running;SEARCH for Diabetes in Youth;social determinants;social health determinants;social influence;Standardization;Statistical Methods;study population;Subcategory;Subgroup;Testing;Tissues;trait;treatment strategy;Work

PROJECT_TITLE: Metabolomic and genomic expansion of type 2 diabetes subtyping in multiethnic populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-J (M1)]


ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PI_NAMEs: BAHOU, WADIE F;BARASCH, JONATHAN M.;BARON, MARGARET H;KASKEL, FREDERICK JEFFREY (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Academia;Address;Area;Award;Benign;Biological;Biology;Biomedical Engineering;Cancer Education Grant Program;career;career development;Caring;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;college;Communication;Complement Factor H;Development;Development Plans;Developmental Biology;Dimensions;Discipline;Disease;Doctor of Philosophy;Education;Educational Curriculum;Educational process of instructing;Enrollment;Environment;Epidemiology;Evaluation;experience;Faculty;field study;Funding;Genitourinary system;Genomics;Geographic Locations;Goals;Grant;Hematological Disease;Hematology;Hospitals;improved;Individual;innovation;Institution;inter-institutional;interdisciplinary collaboration;Interdisciplinary Study;Journals;K-Series Research Career Programs;Kidney;Kidney Diseases;Knowledge;Learning;Learning Skill;life span;Long Island;Manuscripts;Master of Science;Measures;Medical;Medical center;Medical Education;medical schools;Medicine;meetings;Mentors;Methods;metropolitan;Modeling;multidisciplinary;Nephrology;Neurosciences;New York;New York City;next generation;novel;Peer Review;Performance;Persons;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Program Evaluation;Program Research Project Grants;programs;Publishing;Quality of life;remediation;Renaissance;Request for Applications;Research;Research Design;Research Personnel;Research Training;Scholarship;Science;Scientist;Series;skills;social media;strength training;success;Support System;symposium;System;Technical Expertise;Thinking;Time;TNFSF15 gene;Training;Training Programs;translational scientist;United States National Institutes of Health;Universities;urologic;Urologic Diseases;Urology;verbal;Vocabulary;web site;Woman;Work;Writing

PROJECT_TITLE: New York Consortium for Interdisciplinary Training in Kidney, Urological and Hematological Research (NYC Train KUHR)


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: The present proposal will test the efficacy of two fumarate-based drugs, dimethyl fumarate (DMF) and its derivative IMF, to prevent or delay the development of lethal cardiomyopathy in Friedreich's ataxia (FA). Currently, there are no drug therapies that ameliorate FA cardiomyopathy and most with FA die of the cardiomyopathy in their 30s. We will identify the optimal dosing and determine underlying cardioprotective mechanisms of these drugs in validated mouse models of FA which can generate important pre-clinical data because it would address the primary cause of mortality in Friedreich's patients.

PI_NAMEs: DEDKOVA, ELENA N. (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Aconitate Hydratase;Address;Affect;Age;Animals;Ataxia;Biochemical;Biogenesis;Biological Assay;Body Weight decreased;Cardiac;Cardiac Output;Cardiomyopathies;cardioprotection;Cell Death;Cessation of life;Clinical Trials;Complex;Data;Defect;design;Development;Dose;Drug Kinetics;drug testing;Drug usage;efficacy testing;enzyme activity;Enzymes;Equilibrium;extend lifespan;FDA approved;Fibroblasts;Fibrosis;frataxin;Freezing;Friedreich Ataxia;Fumarates;Gender;Hand Strength;Heart;heart defect;Heart failure;heart function;Heart Hypertrophy;Histone Deacetylase;Histopathology;Human;Impairment;improved;in vivo;Inherited;Iron;knock-down;Knockout Mice;Left Ventricular Ejection Fraction;Left Ventricular Hypertrophy;Libraries;Mediating;Mitochondria;Mitochondrial Proteins;mortality;mouse model;Multiple Sclerosis;multiple sclerosis treatment;Mus;Muscle;Muscle function;Muscle Mitochondria;mutant;Myocardial dysfunction;Myocardium;Myopathy;Necrosis;Neurologic Deficit;novel therapeutic intervention;Oxidation-Reduction;Patients;Pharmaceutical Preparations;Pharmacotherapy;phase 1 study;Physiological;pre-clinical;prevent;Prodrugs;Proteomics;Psoriasis;Recovery of Function;response;Role;Rotarod Performance Test;Safety;Sampling;Sensory;sex;Signal Pathway;Skeletal Muscle;Stroke Volume;Succinate Dehydrogenase;Sulfur;Survival Analysis;Symptoms;Testing;Thick;Time;Tissues;Toxicology;Two-Dimensional Echocardiography;Weight;Wheelchairs;Work

PROJECT_TITLE: Fumarate drugs rescue cardiac dysfunction in mouse models of Friedreich's ataxia

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Genetics;Heart Disease;Muscular Dystrophy;Pediatric;Physical Injury - Accidents and Adverse Effects;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE FDA-approved mineralocorticoid receptor (MR) antagonists (MRAs) have clinical benefits for cardiomyopathy in Duchenne muscular dystrophy (DMD) patients and preclinical benefits on skeletal muscle pathology. However, their effects on skeletal muscle fibroblasts, the cell type involved in deleterious fibrosis, have not been defined. This application will define direct and indirect effects of MRAs on fibroblasts to optimize MR modulation for DMD, other muscle diseases and for muscle injuries.

PI_NAMEs: RAFAEL-FORTNEY, JILL A (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Acute;Affect;Agonist;Aldosterone;antagonist;Autopsy;Cardiac;Cardiomyopathies;Cell Separation;cell type;Cells;Chronic;Chronic Disease;Clinical;Clinical Trials;Coculture Techniques;Communication;Complex;coronary fibrosis;CYP11B2 gene;cytokine;Data;Disease;dosage;Duchenne muscular dystrophy;Dystrophin;Enzymes;experimental study;Extracellular Matrix Proteins;FDA approved;Fibroblasts;Fibronectins;Fibrosis;Gene Expression;Genes;Genetic;genetic approach;Genetic Transcription;Heart failure;Homeostasis;Immune;immune cell infiltrate;improved;in vivo;Inflammatory;injured;Injury;injury and repair;Kidney;Kinetics;Knock-out;Lead;Limb structure;mdx mouse;Membrane;migration;Mineralocorticoid Receptor;Modeling;Molecular Profiling;Mononuclear;mouse model;Mus;Muscle;muscle degeneration;Muscle Fibers;Muscular Dystrophies;muscular dystrophy mouse model;Myelogenous;Myeloid Cells;Myocardium;Myofibroblast;Myopathy;Organ;Pathogenesis;Pathology;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Placebo Control;Population;pre-clinical;prevent;Production;Proliferating;quadriceps muscle;Receptor Signaling;Recording of previous events;Regulation;Respiratory Diaphragm;Respiratory Insufficiency;response to injury;Role;Safety;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;Structure;Therapeutic;Tissues;transcriptome sequencing;trial comparing;Validation;wound healing

PROJECT_TITLE: Functions of skeletal muscle mineralocorticoid receptor signaling in chronic and acute injury

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Pregnant people with type 1 and type 2 diabetes need to take insulin multiple times per day and control their blood sugars strictly to prevent serious pregnancy complications. This project will make changes to a new automatic insulin pump so that it can be used to lessen the burden of managing insulin and improve health outcomes in people with type 1 and type 2 diabetes during pregnancy.

PI_NAMEs: POWE, CAMILLE ELISE (contact);PUTMAN, MELISSA SUSAN

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Achievement;Address;Affect;Age;Algorithms;Bionics;Birth;Birth trauma;Blood Glucose;Bolus Infusion;Carbohydrates;care outcomes;Caring;Clinical;Clinical Research;comparative efficacy;Congenital Abnormality;Continuous Glucose Monitor;Cross-Over Trials;Data;design;Devices;diabetes management;Diabetes Mellitus;diabetes risk;diabetes self-management;Discipline of obstetrics;Dose;emotional distress;Ensure;Exclusion;Female;Fetal Mortality Statistics;follow-up;Glucose;glycemic control;Goals;Guidelines;Health;Hemoglobin;Hyperglycemia;Hypertension;Hypoglycemia;improved;improved outcome;Individual;Insulin;Insulin Infusion Systems;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Investigation;Learning;Life;Link;Maternal Health;Maternal Mortality;Modification;Morbidity - disease rate;neonatal health;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Pancreas;Participant;participant enrollment;Patients;Personal Satisfaction;Persons;Population;Pregnancy;Pregnancy Complications;pregnancy disorder;Pregnancy in Diabetics;pregnant;Premature Birth;Prevalence;prevent;psychosocial outcome;Qualifying;Randomized;randomized trial;Recommendation;Research Personnel;Risk;Safety;safety outcomes;Self Administration;Self Management;Severities;stillbirth;System;Technology;Time;tool;treatment as usual;trial comparing;type I and type II diabetes;United States;United States Food and Drug Administration;vigilance;Weight;Work

PROJECT_TITLE: Clinical Studies Investigating Use of the Bionic Pancreas in Pregnancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-M (M1)]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Hearing loss and balance problems affect millions of people world-wide and are most commonly caused by loss of specialized cells called hair cells, which are small mechanical sensors that send information about hearing and balance to the brain. In this project, we use mouse tissues to understand the different types of RNA that cells from the inner ear organs make. We will look to see how different types of RNA shape these organs in young and adult mice to ultimately learn how to treat hearing and balance disorders in the future.

PI_NAMEs: JAN, TAHA A (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: ablative procedure;Adult;Affect;Aging;Alternative Splicing;Apical;Auditory;Auditory system;base;Brain;candidate validation;CDH23 gene;cell type;Cells;Centers for Disease Control and Prevention (U.S.);Central Nervous System;Chronic Disease;Cochlea;Cochlear Implants;computerized tools;Data;deafness;detection method;Development;Diabetes Mellitus;Environmental Exposure;equilibration disorder;Equilibrium;Event;Exons;Exposure to;Functional disorder;functional outcomes;Future;Genes;Genetic;genetic architecture;Genetic Transcription;Hair Cells;Hearing;Hearing Aids;hearing impairment;Hearing problem;Heterogeneity;Homeostasis;Human;Individual;inner ear development;Inner Hair Cells;insight;Labyrinth;Lead;Learning;Length;Link;Malignant Neoplasms;Mammals;Maps;Mechanics;Messenger RNA;Methods;Molecular;mRNA Precursor;mRNA sequencing;Mus;Mutation;noise exposure;novel;Organ;ototoxicity;Outer Hair Cells;pathogen;Pathology;PCDH15 gene;Peripheral;Persons;Pharmaceutical Preparations;Phenotype;Physical therapy;posttranscriptional;programs;Protein Isoforms;Proteins;Regulation;Reporting;Resolution;RNA;RNA Splicing;RNA-Binding Proteins;Role;sensor;Sensorineural Hearing Loss;Sensory Disorders;Shapes;side effect;single-cell RNA sequencing;Specificity;Spliced Genes;Structure;targeted treatment;Techniques;Technology;Testing;Tissues;Transcript;Transcriptional Regulation;transcriptome;transcriptomics;Translations;Untranslated RNA;USH1C gene;Utricle structure;Validation;Variant;Vestibular Diseases;Vestibular dysfunction;vestibular system;Vestibule;Work

PROJECT_TITLE: Alternative splicing in the mouse inner ear at single cell resolution

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Rare Diseases

ORG_CITY: SAN MARCOS

ORG_DEPT: BIOLOGY

ORG_NAME: CALIFORNIA STATE UNIVERSITY SAN MARCOS

PHR: Project Narrative Myotonic dystrophy type 2 is a genetic disorder characterized by progressive muscle wasting and weakness that is caused by long CCTG DNA repeats. Individuals can have up to 11,000 CCTG repeats within the gene responsible for disease. The proposed project will elucidate the molecular mechanisms of long CCTG repeats including contractions, DNA fragility, and effects on transcription using budding yeast S. cerevisiae as an experimental model system.

PI_NAMEs: KIM, JANE C (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: 3' Untranslated Regions;Affect;Biological Assay;Biological Models;Bypass;California;Cells;Chromosomal translocation;Chromosome Fragility;Complex;Disease;DNA;DNA biosynthesis;DNA Double Strand Break;DNA Repair;Educational Models;Etiology;Experimental Models;Foundations;gain of function;Gene Expression;Genes;Genetic;genetic analysis;genetic approach;Genetic Diseases;Genetic Recombination;Genetic Transcription;genome wide association study;Genomic DNA;genomic locus;Genomics;Goals;Health;homologous recombination;Human;Human Genome;in vivo;Incidence;Individual;insight;Introns;Length;Link;Location;Mentors;Mismatch Repair;model organism;Molecular;Molecular Biology;MSH3 gene;Muscle Weakness;Muscular Atrophy;mutant;Myotonic Dystrophy;Myotonic dystrophy type 2;Northern Blotting;Pathway interactions;Persons;Positioning Attribute;Process;programs;Protein Binding Domain;Proteins;Publishing;repaired;Replication Origin;Reporter Genes;Research;Research Personnel;RNA;RNA Splicing;Role;Saccharomyces cerevisiae;Saccharomycetales;Structure;Students;System;Tandem Repeat Sequences;telomere;Testing;Toxic effect;Transcript;Trinucleotide Repeat Expansion;Trinucleotide Repeats;undergraduate research;Universities;Yeasts

PROJECT_TITLE: Molecular Consequences of Myotonic Dystrophy Type 2-causing CCTG DNA Repeats

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-V (81)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Type 1 diabetes (T1D) is a prevalent childhood autoimmune disease, marked by the immune-driven destruction of insulin-producing pancreatic islet cells. Our proposed ancillary study within the Environmental Determinants of Diabetes in Young (TEDDY) project aims to enhance our comprehension of the relationship between infections in T1D triggering and progression, focusing on pivotal moments like autoantibody "seroconversion" and "stage 3 diabetes disease onset." This research will contribute to the advancement of innovative prevention approaches, including vaccination and other antimicrobial strategies.

PI_NAMEs: HAGOPIAN, WILLIAM A.;HYÖTY, HEIKKI ;LABAER, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Address;Ancillary Study;Antibodies;antibody detection;Antibody Response;antibody test;Antigen Targeting;Antigens;antimicrobial;Arizona;Autoantibodies;Autoimmune Diseases;Bacteria;biomarker discovery;Birth;candidate selection;Characteristics;Child;Child Development;Childhood;Clinical;cohort;Cohort Studies;comparison control;Complex;Comprehension;Data;Data Analyses;Development;Diabetes Mellitus;diabetes pathogenesis;diabetes risk;Disease;Disease susceptibility;early childhood;Endocrinologist;Environmental Risk Factor;Epitopes;Etiology;Event;experience;Exposure to;Faculty;Feces;Florida;Genes;Genetic;Goals;Immune;Immune response;Individual;infancy;Infection;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;islet autoimmunity;Islet Cell;Islets of Langerhans;Knowledge;Link;Measures;Mediating;Medical Oncologist;Metagenomics;Methodology;Methods;Microbe;microbial;Modernization;multidisciplinary;Nucleic Acids;Onset of illness;Pacific Northwest;Parasites;Pathogenesis;Performance;prevent;Prevention approach;prospective;Prospective Studies;Protein Array;Protein Array Analysis;Proteins;Proteomics;Research;Research Design;Research Institute;Resources;Risk;Role;Sampling;screening;Seasons;seroconversion;Serum;Shapes;statistics;study population;Technology;Testing;Time;Universities;Vaccination;Vaccines;virome;Virus;Virus Diseases;Washington

PROJECT_TITLE: Whole Protein Arrays to Detect Antimicrobial Antibodies Associated with Triggering and Progression of Islet Autoimmunity in TEDDY

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-J (M2)]


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Diabetes;Neurosciences;Pediatric

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Many individuals living with Type 1 diabetes (T1D) experience significant cognitive impairments, and strategies to decrease the likelihood of this chronic disease complication are needed. With this application, we propose a study to be implemented by a collaborative multisite consortium that will work with stakeholder partners to address current gaps in our knowledge regarding the underpinnings of neurocognitive changes in very young children with T1D. Success will ultimately be measured by the consortium elucidating modifiable determinants, enabling strategies to optimize neurocognitive functioning for persons living with T1D throughout their lifespans.

PI_NAMEs: DIMEGLIO, LINDA A (contact)

PROJECT_TERMS: 5 year old;6 year old;8 year old;Address;Adult;age group;Anisotropy;Biometry;Brain;brain magnetic resonance imaging;brain volume;Caring;Child;Childhood;Chronic Disease;Clinical;Clinical assessments;clinical center;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive performance;cognitive testing;cohort;comparison control;Complication;Complications of Diabetes Mellitus;Control Groups;Data Collection;design;Development;diabetes management;Diabetes Mellitus;Diabetic Ketoacidosis;Diagnosis;Disease;Disease Management;early childhood;Endocrinologist;Enrollment;Ensure;Environmental Risk Factor;Episodic memory;executive function;experience;Goals;gray matter;Guidelines;Hippocampus;Hyperglycemia;Image;Impaired cognition;Impairment;improved;Indiana;Individual;Insulin;Insulin-Dependent Diabetes Mellitus;Intelligence;Knowledge;life span;Measurable;Measurement;Measures;Monitor;Multicenter Studies;Neurocognitive;neuroimaging;neuropathology;Outcome;Participant;Patients;Performance;Persons;Population;prepuberty;Prevention;processing speed;prospective;protective factors;Protocols documentation;Psychologist;radiologist;recruit;Reproducibility;Research;Research Personnel;Risk Factors;Short-Term Memory;Site;Structure;success;Technology;Temporal Lobe;Therapeutic;Time;time use;United States National Institutes of Health;Universities;white matter;Work

PROJECT_TITLE: Neurocognitive Effects of Type 1 Diabetes in Young Children: Indiana University Clinical Center


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative  Brain connections undergo short- and long-term modifications during developmental refinement of neural circuits, as well as in learning and memory. The proposed study investigates the actin-based mechanism underlying the development and modification of chemical synapses. This line of work is directly relevant to public health since it will contribute to our understanding of brain development and functions under both physiological and pathological conditions.

PI_NAMEs: ZHENG, JAMES Q (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Actin-Binding Protein;Actins;Binding;Binding Proteins;Biochemical;Brain;Brain Diseases;Bundling;cell motility;Cell Physiology;Cells;Cellular Structures;Chemical Synapse;Complex;Coupled;Coupling;crosslink;Cytoskeleton;Data;Dendritic Spines;density;Development;Disease;Event;Excitatory Synapse;F-Actin;Family;fascin;Filament;Filopodia;G Actin;Goals;Head;high resolution imaging;Impairment;Individual;innovation;Learning;live cell imaging;Long-Term Potentiation;loss of function;Membrane;Memory;Mental Depression;Microfilaments;Modeling;Modification;Molecular;molecular dynamics;monomer;Morphology;Motility;Mutagenesis;Neck;neural;neural circuit;neuronal circuitry;Neurotransmitter Receptor;novel;Optics;Pathologic;Pattern;Physiological;Play;polymerization;Polymers;postsynaptic;postsynaptic density protein;presynaptic;Presynaptic Terminals;profilin;Proteins;Public Health;Regulation;Reporting;Role;Scaffolding Protein;Site;spatiotemporal;Structure;superresolution microscopy;Surface;Synapses;Synaptic plasticity;Synaptic Receptors;Synaptic Transmission;synaptogenesis;Techniques;Testing;Textbooks;Thymosin;trafficking;Vertebral column;Work

PROJECT_TITLE: Actin Cytoskeleton in Postsynaptic Structure and Function

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ORG_CITY: NEW ORLEANS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: The research proposed in this grant is to elucidate the genetic mechanisms programming the sex-specific response to the selective estrogen receptor modulator (SERM) bazedoxifene that protect pancreatic β cells. Successful completion of this work could fill key gaps in our understanding of the fundamental genetic modifiers of sex-specific β cell function and failure with implication for sex-based precision medicine of type 2 diabetes. PHS 398/2590 (Rev. 11/07) Page Continuation Format Page

PI_NAMEs: MAUVAIS-JARVIS, FRANCK  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Acute;Affect;Agonist;antagonist;Architecture;base;Beta Cell;Bioinformatics;Biology;black men;Cell Physiology;Cells;Chronic;clinically relevant;Data;Development;diabetes pathogenesis;Disease;Environment;Epigenetic Process;ESR1 gene;Estrogen Receptors;Exhibits;experience;Exposure to;Failure;Female;Functional disorder;Gene Dosage;Gene Expression;Genes;Genetic;genotypic sex;Goals;Gonadal Steroid Hormones;Grant;Hormonal;Hormones;Human;human female;Hyperglycemia;In Vitro;in vivo;Injury;insight;Insulin deficiency;Insulin-Dependent Diabetes Mellitus;Investigation;islet;Islets of Langerhans;Laboratories;Ligands;male;men;Menopause;Methods;Missense Mutation;Modeling;Molecular;mouse model;Mus;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Oxidative Stress;pancreatic islet function;Pathogenesis;Pharmaceutical Preparations;pharmacologic;Physiological;precision medicine;programs;Puberty;Publishing;Qualifying;Reagent;Research;response;Selective Estrogen Receptor Modulators;sex;Sex Chromosomes;Sex Differences;single cell genomics;single-cell RNA sequencing;Stanolone;Steroid Receptors;Structure of beta Cell of islet;Testosterone;Therapeutic;Tissues;tool;transcription factor;Translating;treatment response;Woman;Work;X Chromosome

PROJECT_TITLE: Genetic and molecular architecture of sex-specific drug response in human islets

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Mental Health;Mental Illness;Microbiome;Neurosciences;Nutrition;Schizophrenia;Serious Mental Illness

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE  People with schizophrenia are characterized by marked impairments in cognitive function, for which there are no current pharmacological treatments. The development of an effective intervention for cognitive impairments remains a major therapeutic challenge. Prebiotics are dietary fibers that promote the growth or activity of gut microorganisms, which leads to the enhanced well-being of the host. The proposed R61 and R33 projects are designed to evaluate the hypothesis that prebiotic administration will lead to increased production of butyrate, through increased activity of butyrate-producing bacteria in the gut microbiota; the increase in serum butyrate levels will be associated with changes in cognitive function, symptoms, and metabolic measures.

PI_NAMEs: BUCHANAN, ROBERT W (contact)

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: Acetates;Affect;Affective Symptoms;Aftercare;Attention;Bacteria;Behavior;Biological;Brain;Butyrates;Cholesterol;Chromatin Structure;Chromosome 6;Clinical;cognitive benefits;cognitive function;cognitive performance;cytokine;Data;design;Development;Dietary Fiber;Disease;Double-Blind Method;effective intervention;effective therapy;efficacy trial;Enzymes;executive function;Family;Fasting;functional outcomes;Gene Expression;Genetic Polymorphism;Glucose;Growth;gut bacteria;gut microbiome;gut microbiota;Histone Deacetylase Inhibitor;Immune system;immune system function;immunoregulation;Impaired cognition;Impairment;improved;Incidence;Inflammatory;interest;Intervention;intestinal barrier;Intestinal permeability;Inulin;Light;Lipids;MATRICS Consensus Cognitive Battery;Measures;Mediating;Memory;Metabolic;microbiota composition;Microglia;microorganism;Multiple Abnormalities;Neurocognitive Deficit;Nonpharmacologic Therapy;novel strategies;Nuclear;Outcome;Participant;Pathway interactions;Performance;Personal Satisfaction;Persons;pharmacologic;Pharmacological Treatment;Placebos;prebiotics;processing speed;Production;Propionates;psychiatric symptom;Randomized;randomized placebo-controlled clinical trial;receptor;recruit;Schizophrenia;Secondary to;Serum;Short-Term Memory;side effect;social cognition;Symptoms;Therapeutic;Triglycerides;Verbal Learning;visual learning;Volatile Fatty Acids

PROJECT_TITLE: Prebiotic Treatment in People with Schizophrenia


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Project Narrative Organ transplantation as a lifesaving therapy remains constrained by severe complications associated with lifelong immunosuppression and relentless graft loss over time. Our project is designed to uncover novel mechanisms of innate immune responses that hinder transplant survival. Our proposed studies will also have broad implications in the design of new innovative therapies for transplant patients as well as for patients with autoimmune diseases and cancers.

PI_NAMEs: LI, XIAN CHANG (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Acetylation;Acute;Address;Affect;Alleles;allograft rejection;Allograft Tolerance;Allografting;Animal Model;ATAC-seq;Autoimmune Diseases;Autologous;Automobile Driving;Binding;Cell Surface Receptors;Cell Survival;cell type;Cells;ChIP-seq;chromatin modification;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Chronic;Clinic;Data;design;Enhancers;Epigenetic Process;epigenomics;Event;Exclusion;Exhibits;Family member;Gene Expression;Generations;Genes;Genetic Transcription;genome-wide;Goals;Heart;Heart Transplantation;Immune;Immunosuppression;improved;in vivo;Infiltration;innate immune mechanisms;Innate Immune Response;Innate Immune System;Innovative Therapy;ITGAM gene;Kidney;Knowledge;Life;Ligands;Link;Longevity;Macrophage;Macrophage Activation;Maintenance;Malignant Neoplasms;Mediating;member;Memory;Metabolic;MHC Class I Genes;multiple omics;Mus;Myelogenous;Myeloid Cells;NF-kappa B;novel;Organ Transplantation;Outcome;Pathway interactions;Patients;Phenotype;Population;Positioning Attribute;programs;Protein Isoforms;receptor;receptor binding;Reperfusion Injury;Reporting;Repression;response;Role;Science;Signal Pathway;Signal Transduction;Specificity;Structure;Supporting Cell;System;T-Cell Receptor;Testing;Therapeutic immunosuppression;Time;TNFRSF5 gene;tool;Transcript;transcriptome sequencing;transplant model;Transplant Recipients;Transplantation;Transplantation Tolerance;Tumor Necrosis Factor Receptor

PROJECT_TITLE: Modulation of innate immune cells to create transplant tolerance

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE There is considerable interest in understanding factors that impact adolescent experiences of depression. We propose to conduct secondary data analysis with latent class and mixed modeling methods to holistically answer the question “How do caregiver experiences of discrimination, psychosocial factors, and environmental influences interact to influence adolescent depression over time?”. Findings from this study will improve our understanding of these complex dynamics, contribute to a more comprehensive understanding of the factors that impact adolescent depression, and could inform interventions and policies to support the well-being of adolescents in diverse contexts.

PI_NAMEs: CAMPBELL, MIA NOELLE (contact)

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent mental health;Adopted;Adult;adverse outcome;Affect;Age;aged;Biological;Black race;career;Caregivers;Categories;Characteristics;child depression;Child Health;Child Mental Health;Collaborations;Complex;critical developmental period;Data;Data Analyses;Data Set;depressive symptoms;Development;Discrimination;disparity reduction;Early identification;Environment;Environmental Risk Factor;experience;Exposure to;Family;Future;gender difference;gender disparity;Goals;Health;Hispanic;improved;Individual;Influentials;innovation;insight;interest;Intervention;Knowledge;Link;Major Depressive Disorder;Mental Depression;Mental Health;Methodology;Methods;minority children;Mission;Modeling;Mood Disorders;multi-racial;Multivariate Analysis;neighborhood safety;Neighborhoods;next generation;novel;Outcome;Outcomes Research;Pathway interactions;Pattern;peer;perceived discrimination;Personal Satisfaction;physical conditioning;Physical environment;Policies;Population;Prevalence;Prevention;programs;Psyche structure;Psychological Stress;Psychosocial Factor;Public Health;Race;racial discrimination;racial minority;racial minority population;racism;Recreation;Reporting;Research;Research Personnel;Risk Factors;Scholarship;Shapes;single episode major depressive disorder;social;Social Environment;Stress;Students;substance use;suicidal;supportive environment;teacher;theories;Time;Treatment/Psychosocial Effects;trend;United States;United States National Institutes of Health;vulnerable adolescent;Vulnerable Populations;Walking

PROJECT_TITLE: Understanding longitudinal trajectories of environmental factors and depression among minoritized adolescents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-F (50)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: It is unclear as to why and how fasting glucose concentrations rise in prediabetes independently of the ability to handle an oral challenge. This has implications for strategies to prevent diabetes and its complications. We propose a novel series of experiments designed to understand the regulation of fasting glucose metabolism.

PI_NAMEs: VELLA, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acute;Affect;Alpha Cell;Beta Cell;Biological Markers;biomarker identification;Cell Physiology;Cell secretion;Characteristics;Defect;Development;Diabetes Mellitus;Disease;Early identification;endoplasmic reticulum stress;Experimental Designs;experimental study;Fasting;fasting glucose;Feedback;Frequencies;Functional disorder;Glucagon;Glucose;glucose metabolism;glucose production;glucose tolerance;Glycosylated hemoglobin A;Health;Hepatic;Heterogeneity;Hormones;Human;Hyperglycemia;Hyperinsulinism;Impaired fasting glycaemia;Impairment;indexing;Insulin;Insulin Resistance;insulin secretion;insulin signaling;Intervention;islet;Islet Cell;Knowledge;Measures;Methodology;Methods;Microvascular Dysfunction;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;Oral;Pathogenesis;Peripheral;Persons;Physiologic pulse;Prediabetes syndrome;prevent;Prevention;Proinsulin;Regulation;response;restraint;Rodent;Role;Series;System;Variant;Work

PROJECT_TITLE: The regulation of fasting glucose metabolism in people with and without prediabetes

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Many children with type 1 diabetes (T1D) are at risk of neurocognitive impairments, and these children often struggle with memory and learning deficits and the ability to pay attention. Throughout the study, our team will observe a group of diverse children with a new T1D diagnosis, and age-matched healthy control children, to identify nutritional and lifestyle behaviors, environmental exposures, and social determinants of health (SDOH) known to contribute to these neurocognitive outcomes. Our team will study these children over time to explore the potential protective effects of diabetes management technologies and other factors to defend children’s thinking and processing function and to protect their brain development.

PI_NAMEs: PAGE, KATHLEEN ALANNA (contact);RAYMOND, JENNIFER K;XIANG, ANNY H

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: Address;Adverse effects;Affect;Age;Attention;Behavior;biobank;Biological Markers;Birth;Brain;brain volume;California;Child;Childhood;Clinical;clinical center;clinical risk;cohort;Collaborations;Communities;Continuous Glucose Monitor;Development;diabetes management;Diabetes Mellitus;Diabetic Ketoacidosis;Diagnosis;Diet;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;Ethnic Origin;Ethnic Population;Evaluation;executive function;experience;Exposure to;Family;Frequencies;Future;Gender;glycemic control;Glycosylated hemoglobin A;Goals;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Investigation;Knowledge;Latinx;Learning;Life Style;lifestyle factors;Longitudinal Studies;Los Angeles;Measurement;Memory;Metabolic;Methods;Minority Groups;Monitor;multi-ethnic;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Neurocognitive;Neurocognitive Deficit;neurodevelopment;neuroimaging;Neuropsychology;Newly Diagnosed;Nutritional;Obesity;Outcome;Participant;patient population;Pediatric Hospitals;peer;Physical activity;Plasma;Population;Population Heterogeneity;predictive marker;Predisposition;prenatal exposure;prepuberty;protective effect;protective factors;Protocols documentation;Race;racial difference;recruit;Resources;Risk;Risk Factors;Severities;Severity of illness;sex;sex assigned;Site;Sleep;social factors;social health determinants;stool sample;Structure;Subgroup;System;Technology;Thinking;Time;U-Series Cooperative Agreements;Underserved Population;Urine;white matter;Work;Youth

PROJECT_TITLE: Longitudinal Evaluation of Neurocognitive Complications in Pediatric Type 1 Diabetes Across Multi-Ethnic Groups—Exploring Risk and Protective Factors


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Emphysema;Genetics;Lung;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE One of the leading causes of morbidity and mortality worldwide are lung diseases, including Chronic Obstructive Pulmonary Disorder (COPD) and other chronic lung diseases (CLDs) which have no cure, have poor patient outcomes and increasing rapidly in prevalence. The Molecular Atlas of Lung Development Program (LungMap3) was created with the overarching goal to characterize the cellular and molecular causes of lung diseases in order to develop novel and more efficacious therapies. For LungMAP Phase 3, we propose to focus on three emerging concepts and current challenges in the field: 1) accurately and precisely phenotype adult human lung diseases at the spatial and single cell level with a focus on COPD, CLDs and more rare diseases including alpha-1 anti- trypsin deficiency (A1AT), 2) identify the molecular defects present in progenitor cell populations in human CLDs through spatial and genomic single cell resolution technologies, and 3) develop and implement new research models to better define the molecular and cellular defects that occur during the progression of CLDs.

PI_NAMEs: MORRISEY, EDWARD E (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Adult;alpha 1-Antitrypsin;alpha 1-Antitrypsin Deficiency;Alveolar;alveolar epithelium;Atlases;biobank;Bioinformatics;Biological Assay;Biological Models;Bronchopulmonary Dysplasia;burden of illness;care systems;Catalogs;Cause of Death;cell behavior;Cell Communication;Cell Lineage;cell type;Cells;Cellular biology;Childhood;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Communities;Computer software;Data;Defect;Disease;Disease Progression;disorder risk;efficacious treatment;epigenomics;Foundations;Funding;Gene Expression;Gene Expression Alteration;gene regulatory network;genetic signature;Goals;Heterogeneity;Homeostasis;Human;Human Development;human model;in vivo;Informatics;Injury;insight;intercellular communication;interest;Knowledge;knowledge base;Lead;life span;Lung;lung development;Lung Diseases;Maps;Medical;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Natural regeneration;novel;novel strategies;novel therapeutics;Organoids;Pathology;patient population;Patient-Focused Outcomes;Patients;Phase;Phenotype;Physiological;postnatal human;Prevalence;Productivity;Program Development;Pulmonary Emphysema;Quality of life;Rare Diseases;Regulation;Research;Resolution;respiratory;Respiratory Disease;Respiratory System;Role;Sampling;Secretory Cell;Severity of illness;single cell analysis;single cell genomics;stem cell differentiation;stem cell function;stem cell niche;stem cell population;stem cells;Structure of parenchyma of lung;Technology;Testing;Tissue Banks;Tissues;transcriptomics;Validation;Variant;web platform

PROJECT_TITLE: The Penn LungMAP 3 team: Defining chronic lung disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (M1)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative In Alzheimer’s disease, immune cells in the brain called microglial cells become activated and drive disease. We will investigate the ability of regulatory T cells induced by the nasal administration of a monoclonal antibody against T cells to treat the 3xTg mouse model of AD by decreasing microglia and astrocyte activation. Our studies have translational possibilities given that such an antibody has been given to healthy volunteers and has shown positive effects in a pilot study of subjects suffering from COVID-19.

PI_NAMEs: WEINER, HOWARD L (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: 3xTg-AD mouse;abeta deposition;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Animal Model;Antibodies;Astrocytes;Autopsy;Axon;behavior test;Biodistribution;Brain;CD3 Antigens;cell motility;Cell secretion;Cells;Cervical lymph node group;Chronic;Cognitive deficits;COVID-19;Data;Differentiation Antigens;Disease;Disease associated microglia;Disease Progression;Dose;Drug Kinetics;Experimental Autoimmune Encephalomyelitis;Fluorescent in Situ Hybridization;FOXP3 gene;genetic signature;glial activation;healthy volunteer;High-Throughput RNA Sequencing;Histopathology;Immune;Immunohistochemistry;improved;in vivo;Inflammatory;Interleukin-10;Investigation;Knockout Mice;Label;Location;Maps;Measures;Microglia;migration;Monoclonal Antibodies;mouse model;Mus;Nerve Degeneration;Neuroglia;neuroinflammation;Neurons;neuroprotection;Nose;Pathogenesis;Pathway interactions;Phagocytes;Phenotype;Pilot Projects;Population;Positron-Emission Tomography;Radio;Regimen;Regulatory T-Lymphocyte;research clinical testing;Rest;Role;Senile Plaques;Signal Transduction;Site;Study Subject;T-Lymphocyte;Tamoxifen;tau Proteins;Therapeutic;Tracer;transcription factor

PROJECT_TITLE: Mechanisms underlying the neuroprotective effect of nasal administration of anti-CD3 in AD mouse models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: JOSLIN DIABETES CENTER

PHR: NARRATIVE The current MPI project seeks to evaluate neurocognitive complications in prepubertal onset type 1 diabetes and identify potential risk and protective factors of brain health. Investigators at Joslin Diabetes Center (JCD) and Boston Children’s Hospital (BCH) seek to become a joint clinical center in the proposed consortium to investigate neurocognitive complications in the proposed two year observational study comparing neuroimaging, neurocognitive evaluations, psychological assessments, and clinical evaluations between young children with prepubertal onset of pediatric type 1 diabetes and a matched normative sample of young children.

PI_NAMEs: LAFFEL, LORI M (contact);LENNERZ, BELINDA S

PROJECT_TERMS: Adult;Age;aged;Anatomy;Area;Assessment tool;Boston;Brain;brain health;Child;Childhood;Clinical;clinical center;Clinical Management;Clinical Research;cloud based;Cognition;Cognitive;cognitive function;Collaborations;Collection;comorbidity;Continuous Glucose Monitor;Control Groups;Data;data management;Data Set;design;Development;Devices;diabetes management;Diabetes Mellitus;Diagnosis;Diffusion;Disease Management;early childhood;Early Intervention;Ensure;Ethnic Origin;Evaluation;Family;Functional disorder;Functional Magnetic Resonance Imaging;functional outcomes;glycemic control;Goals;gray matter;Health;health assessment;health equity;Hospitals;Image;Information Dissemination;inner city;instrument;Insulin;insulin dependent diabetes mellitus onset;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;interest;Intervention;Joints;Knowledge;lifestyle factors;Link;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Medical center;member;Metabolic;Monitor;multidisciplinary;myelination;Neurocognition;Neurocognitive;neurocognitive test;neuroimaging;Neuropsychology;Newly Diagnosed;Observational Study;Outcome;Participant;Pediatric cohort;Pediatric Hospitals;Performance;PhenX Toolkit;Physiological;prepuberty;preservation;prevent;Prevention;preventive intervention;Prospective cohort;protective factors;Protocols documentation;psychologic;psychological outcomes;psychosocial;Psychosocial Factor;public repository;Publishing;Race;recruit;repository;Research;research clinical testing;Research Personnel;Resources;Rest;Risk Factors;safety net;Sampling;sex;Site;Social Functioning;social health determinants;socioeconomic diversity;Specific qualifier value;Standardization;Statistical Models;Structure;Technology;Thick;Time;United States National Institutes of Health;white matter;Youth

PROJECT_TITLE: Identifying Targets for Preventing Neurocognitive Complications in Youth with T1D

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-1 (M3)]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

PHR: PROJECT NARRATIVE The long-term goal of this proposal is to improve outcomes for bilingual patients in the Audiology Clinic. Bilingual listeners, even those who are highly proficient in their non-native language(s), may experience challenges when communicating in acoustically complex environments that are not accurately captured by current patient reported outcome measures utilized by clinicians. This work aims to determine the considerations necessary for interpreting patient reported outcome measures with a bilingual patient population, by establishing the relationships between objective and subjective suprathreshold auditory performance, native speaker status, and aging in bilingual adults.

PI_NAMEs: BIEBER, REBECCA  (contact);PHILLIPS, IAN

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Accounting;Acoustics;active duty;Adult;Age;age acceleration;age effect;age related;age related changes;age related decline;Age-associated memory impairment;aged;Aging;aging population;Audiology;Auditory;Automobile Driving;bilingualism;Caring;Clinic;Clinical;clinical care;clinical decision-making;Cognition;Cognitive;cognitive capacity;Communication;Compensation;Complex;Decision Making;Demographic Factors;Early Intervention;early onset;Environment;Equation;evidence base;Exhibits;experience;follow-up;Foundations;Goals;Hearing;hearing impairment;Impaired cognition;improved;improved outcome;Individual;Individual Differences;Instruction;Intervention;Knowledge;Laboratories;Language;Life;Linguistics;Measurement;Measures;member;middle age;Minority Groups;multiple data sources;National Institute on Deafness and Other Communication Disorders;Noise;noise perception;non-Native;normal hearing;Outcome Measure;Participant;Patient Outcomes Assessments;patient population;Patients;Performance;Peripheral;Population;Quality of life;Questionnaires;Recommendation;Recording of previous events;recruit;Reporting;Research;Research Support;response;service member;Speech;speech in noise;Standardization;System;Techniques;Test Result;Testing;tool;United States;Work;Writing

PROJECT_TITLE: Improving Interpretation of Hearing- Related Patient Reported Outcomes for Bilingual Adults


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Contraception/Reproduction;Diabetes;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative This planned research will enroll a large, diverse cohort of pre-pubertal children shortly after T1D diagnosis, as well as comparison participants without T1D, and assess differences in cognitive function, academic achievement, MRI-based microstructural, volumetric, functional and physiological measures, as well as their relationship to glycemic and non-glycemic factors. We hypothesize that: 1) T1D impacts the developing brain, producing impairments in neurocognitive functioning compared to controls; 2) these impairments are mediated by risk and protective factors, such as magnitude and duration of blood glucose time in range, time spent in hypoglycemia or hyperglycemia, and episodes of severe hypoglycemia and DKA; and 3) indirect effects of hyperglycemia and non-glycemic factors will mediate the effect of hyperglycemia on cognitive function and brain development in children with T1D. The NYU Clinical Center (NYU CC) and the assembled team in this proposal have expertise in neurocognitive studies in T1D, neuroimaging in young children, diabetes management, data management, quality control, statistical analysis, and stakeholder engagement and aim to participate actively and collaboratively with the Biostatistics Research Coordinating Center (BRC), NIH, and other CC clinical sites in designing and implementing the study protocol to engage and follow a diverse population sample of children with recent onset of T1D and then disseminate the findings from the study.

PI_NAMEs: CASTELLANOS, FRANCISCO XAVIER;GALLAGHER, MARY PATRICIA (contact);JACOBSON, ALAN M

PROJECT_TERMS: 10 year old;Academic achievement;Adolescent;Affect;Age;Age of Onset;age related;Area;Biometry;biophysical model;Blood Glucose;Brain;Brain imaging;candidate marker;Child;Childhood diabetes;Chronic;clinical center;clinical research site;Cognition;Cognitive;cognitive function;cognitive performance;cognitive testing;cohort;Collaborations;comparison control;comparison group;Continuous Glucose Monitor;Data;data management;design;Development;diabetes management;Diabetes Mellitus;Diabetic Ketoacidosis;Diagnosis;Diffusion;Educational Status;Enrollment;Event;experience;Exposure to;Family;follow-up;Frequencies;Glucose;gray matter;Growth;Health;Hyperglycemia;Hypoglycemia;Image;imaging study;Impaired cognition;Impairment;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Metabolic;Metabolic Control;Methods;Neurocognitive;neurocognitive test;neurodevelopment;neuroimaging;New York;novel;Onset of illness;Outcome;Participant;peer;Physical activity;Physiological;Physiology;Population Heterogeneity;Positioning Attribute;prepuberty;protective factors;Protocols documentation;psychologic;psychosocial;Puberty;Quality Control;Recording of previous events;recruit;Regimen;Research;Research Design;Research Personnel;Risk;Risk Factors;Sampling;Series;Severities;Sleep;social determinants;social health determinants;Statistical Data Interpretation;structural imaging;Structure;Techniques;Teenagers;Testing;Time;United States National Institutes of Health;Universities;white matter;Youth

PROJECT_TITLE: Evaluating Neurocognitive Complications of Type 1 Diabetes (T1D) and Potential Risk and Protective Factors in Pre-Pubertal Children- New York University Clinical Center


NIH_SPENDING_CATS: Data Science;Lung;Networking and Information Technology R&D (NITRD)

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE Diseases of the lung are among the leading causes of death in the United States and worldwide. In Phase 3 of the Molecular Atlas of Lung Development Program (LungMAP), the data coordination center (DCC) in conjunction with its research centers and human tissue core, will work to define the regulatory mechanisms of lung disease progression and nominate new targets for therapy. To achieve this goal, the DCC will develop advanced systems biology resources and tools leveraging advances in artificial intelligence, harmonize LungMAP datasets and will coordinate educational outreach. 2

PI_NAMEs: ARONOW, BRUCE J;SALOMONIS, NATHAN G. (contact)

PROJECT_TERMS: Administrative Coordination;advanced system;Animal Model;Artificial Intelligence;Atlases;Automated Annotation;Benchmarking;Biological Models;Biology;Catalogs;Cause of Death;cell type;Cells;Cellular Structures;Chronic Obstructive Pulmonary Disease;cloud based;cohort;Collaborations;Collection;Communities;community partners;COVID-19;Data;Data Coordinating Center;data dissemination;data harmonization;data integration;Data Provenance;data resource;Data Set;Data Sources;Databases;Disease;Disease Progression;disorder subtype;distributed data;Ecosystem;Education;Education and Outreach;Educational workshop;Future;gene regulatory network;Generations;Genes;global health;Goals;Human;human tissue;Image;Imaging technology;Individual;Infrastructure;Ingestion;Institution;Knowledge;knowledge base;Lead;literacy;Lung;lung development;Lung Diseases;Metadata;Modeling;Molecular;Multiomic Data;multiple omics;Mutation;new therapeutic target;next generation;novel;online resource;Ontology;Pathologic;Patients;Pharmaceutical Preparations;Phase;Process;Program Development;programs;Reporting;Research;Research Personnel;Resources;Sampling;skill acquisition;Standardization;synergism;System;Systems Biology;Technology;tool;training data;transcriptomics;United States;Validation;Visualization;web portal;Work;working group

PROJECT_TITLE: Molecular Atlas of Lung Development Program (LungMAP) Phase 3 - Data Coordinating Center


ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PHR: NARRATIVE Type 1 Diabetes (T1D) presents a major health hazard to our population and can be devastating to the individual, even with exogenous insulin treatment. The first immunotherapy was recently approved to delay progression to T1D, but there is no prevention or cure. Prevention will be enabled by understanding earlier pathogenesis. The proposed studies will investigate clonal expansion of T cells in stage 1 T1D as a biomarker of disease activity. These studies may guide timing and selection of early therapies.

PI_NAMEs: CEROSALETTI, KAREN M;LINSLEY, PETER S;LONG, S ALICE  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: activity marker;Address;Age;Antigen Receptors;antigen-specific T cells;Antigens;Appearance;Autoantibodies;Autoimmune Diseases;Autoimmunity;autoreactivity;B-Cell Antigen Receptor;B-Lymphocytes;Beta Cell;Biological Assay;Biological Markers;CD32 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Separation;cell type;Cells;Cellular Immunology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical Trials;Clonal Expansion;cohort;Communicable Diseases;Coupled;Data;Dependence;diabetes pathogenesis;Diagnosis;Disease;Disease Marker;Disease Progression;early detection biomarkers;Early treatment;epigenome;Equilibrium;exhaust;FDA approved;Flare;FOXP3 gene;Frequencies;Goals;Health Hazards;Immune;Immune response;Immunity;Immunologic Markers;Immunotherapy;Individual;Inflammation;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;islet;Islet Cell;Knowledge;Label;Longitudinal cohort;Lytic;Measures;Mediating;MHC Class I Genes;Modeling;Monitor;Nature;Outcome;Pancreas;Pathogenesis;Pathogenicity;Pathogenicity Islets;Pathway interactions;Population;pre-clinical;Pre-Clinical Model;prevent;Prevention;Regulatory T-Lymphocyte;Resolution;Sampling;Site;Stable Disease;Stains;Structure of beta Cell of islet;success;Systems Biology;T-Cell Receptor;T-Lymphocyte;targeted treatment;TC1 Cell;Time;Tissue-Specific Gene Expression;Tissues;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Treatment Efficacy;Work

PROJECT_TITLE: Clonal expansion: a marker of disease activity in stage 1 T1D


NIH_SPENDING_CATS: Genetics

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Human health depends on the appropriate control of gene expression, much of which is exerted at the assembly of the RNA polymerase II (Pol II) preinitiation complex (PIC) at promoters and the successful advance of Pol II into productive elongation. It is generally thought that the local chromatin structure of promoters is an important modulator of these processes but the mechanisms through which such control might occur are not well understood. Our goal is to reveal these mechanisms by biochemically dissecting Pol II initiation and early elongation in vitro in an appropriate chromatin context.

PI_NAMEs: LUSE, DONAL  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Architecture;Binding;Biochemical;Cell Nucleus;Chromatin;Chromatin Structure;Competence;Complex;Distal;DNA;Elements;Gene Expression;Genetic Transcription;Goals;Health;Histone H3;histone modification;Histones;Human;In Vitro;insight;knock-down;Link;Location;Methylation;Minority;Modification;novel;Nuclear Extract;Nucleosomes;Outcome;Play;Polymerase;Positioning Attribute;Positive Transcriptional Elongation Factor B;premature;Process;Productivity;promoter;Reaction;RNA Polymerase II;Role;Series;Surface;System;TAF1 gene;Testing;Time;transcription factor S-II;Transcription Initiation;Transcription Initiation Site;Transcriptional Regulation;Variant;Work

PROJECT_TITLE: The effect of nucleosomes on the earliest stages of RNA polymerase II transcription

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative A better understanding of the impact of failure and approaches that de-stigmatize and normalize failure are needed to assure greater success and retention of diverse students in the biomedical sciences. The goal of this research is to understand the impact of a video intervention on student responses to failure in two educational contexts. This study will test the hypothesis that if students are taught about failures experienced by successful scientists or learn to troubleshoot experiments, they will be less discouraged when they experience difficulties or failures, and therefore more likely to persist in the biomedical sciences.

PI_NAMEs: HANDELSMAN, JO E. (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Affect;African American student;Attitude;Behavior;Behavior assessment;Biology;career;Characteristics;college;Communities;Data;demographics;design;Education;Educational Curriculum;Educational process of instructing;Exclusion;experience;experimental study;Failure;Fright;Future;Goals;Grouping;Growth;Institution;instructor;Intervention;intervention effect;Latinx;Learning;Life;Motivation;peer;Play;Population;Problem Solving;Production;Productivity;Research;resilience;response;Role;Science;science education;Scientist;Self Efficacy;self reported behavior;Seminal;skills;STEM field;Structure;Students;success;Surveys;Talents;Testing;tool;treatment group;undergraduate research experience;United States;university student;Video Games

PROJECT_TITLE: The importance of failure in science education: Interventions to promote STEM motivation through failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-W (RI)]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Microbiome;Skin Cancer

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: Narrative Leveraging discoveries emerging from our previous R35, this proposal extends findings relevant to rewired UPR signaling affecting tumor-intrinsic (ATF4 pro- and anti-apoptotic signaling) and -extrinsic (microbiota composition and anti-tumor immunity) pathways. We propose to study these processes during aging, which provide unprecedented opportunity to study melanoma metastasis, thus offering novel paradigms to address fundamental unanswered questions in cancer biology.

PI_NAMEs: RONAI, ZEEV A. (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Address;Affect;age effect;aged;Aging;animal old age;Apoptotic;Aspartate-Ammonia Ligase;Biology;Cancer Biology;Cell Death;conditional knockout;CRISPR/Cas technology;Glutaryl-CoA dehydrogenase;gut microbiota;Human;innovative technologies;juvenile animal;Knockout Mice;Melanoma;Melanoma Cell;Metabolic;metabolomics;Metastatic Melanoma;microbiota composition;Modeling;Mus;Neoplasm Metastasis;novel;novel strategies;Pathway interactions;Phenotype;Physiological;Process;Regulation;Resistance;Signal Transduction;single-cell RNA sequencing;therapy resistant;transcriptomics;tumor;Tumor Immunity

PROJECT_TITLE: Rewired Signaling at the Nexus of Melanoma Metastasis and Resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-E (M1)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Mental Health;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Neural circuits modulating social anxiety have been identified but the key cell types that drive behaviors are poorly defined. We will use activity dependent tagging to characterize and manipulate neurons in the extended amygdala and nucleus accumbens that modulate social approach and social vigilance.

PI_NAMEs: TRAINOR, BRIAN C (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Affect;Agonist;Amygdaloid structure;antagonist;Anxiety;Anxiety Disorders;approach behavior;avoidance behavior;Behavior;Behavioral;behavioral phenotyping;Biological Models;Brain;Brain region;Calcium;California;Cell Nucleus;cell type;Cells;Clinical Research;comparative;Coupling;Data;Development;Exhibits;experimental study;Female;Future;genome resource;high dimensionality;Hour;Human;Immediate-Early Genes;Individual;Infusion procedures;innovation;insight;interest;Interneurons;Knowledge;Label;Light;Link;male;Mediating;Methods;Modeling;Molecular;Mus;neural;neural circuit;Neurons;novel;novel strategies;novel therapeutic intervention;Nucleus Accumbens;optogenetics;Oxytocin Receptor;Pathway interactions;pharmacologic;Pharmacologic Actions;Phenotype;Primates;Research;Rodent;single nucleus RNA-sequencing;single-cell RNA sequencing;social;social anxiety;Social Anxiety Disorder;Social Behavior;Social Controls;social defeat;Social Environment;Social Interaction;social stress;Stress;Structure of terminal stria nuclei of preoptic region;System;temporal measurement;Testing;Transcript;Transgenic Animals;United States;vigilance;Women's prevalence;Work

PROJECT_TITLE: Cell types controlling social behavior in extended amygdala and nucleus accumbens

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ORG_CITY: PHOENIX

ORG_NAME: TRANSLATIONAL GENOMICS RESEARCH INST

PHR: PROJECT NARRATIVE The risk of a child developing Type 1 Diabetes (T1D) appears to be increased by exposure to particular viruses, but the nature, timing, and strength of such triggers remain ill-defined. By applying a sensitive new technology to study large cohorts sampled throughout childhood, we will catalog the timing and precise cause of 10,000s of virus infections, and determine which correlate with the development of T1D or associated autoimmunity. The resulting insights may enable new strategies to prevent T1D and the morbidity, reduced lifespan and large economic burden that it entails.

PI_NAMEs: ALTIN, JOHN  (contact);LADNER, JASON

PROGRAM_OFFICER_NAME: AKOLKAR, BEENA

PROJECT_TERMS: Address;Affect;Algorithmic Analysis;Antibodies;Antigens;Appearance;Area;Australia;Autoantibodies;Autoimmune;autoimmune pathogenesis;Autoimmunity;Bar Codes;Bioinformatics;Biological Assay;Birth;Catalogs;Cell Culture Techniques;Child;Childhood;cohort;Cohort Analysis;Cohort Studies;Collaborations;Computer software;Data Reporting;Dependence;design;Detection;Development;Diabetes Mellitus;Disease;disorder prevention;DNA Library;Economic Burden;Enrollment;Enterovirus;Environmental Risk Factor;Epidemiology;Epitopes;Etiology;Europe;Event;Experimental Designs;Exposure to;Feces;Frequencies;Future;Genetic;Genetic Predisposition to Disease;genome wide association study;Growth;high risk;human virome;Immunology procedure;Incidence;Infection;Inflammatory;innovation;innovative technologies;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Intervention;islet;islet autoimmunity;Islets of Langerhans;Libraries;Life;Life Expectancy;life span;Link;longitudinal dataset;longitudinal, prospective study;Mediating;microbiome;Molecular;Molecular Mimicry;Morbidity - disease rate;Mothers;Natural History;Nature;new technology;Outcome;Parents;Participant;Pathogenesis;Peptides;Persons;Plasma;Portraits;Pregnancy;prevent;Prevention strategy;Prospective Studies;Recording of previous events;Resolution;Respiratory Tract Infections;Risk;Risk Factors;Role;Sampling;Serology;Site;statistics;Symptoms;T-Lymphocyte;Taxonomy;temporal measurement;Testing;Time;Twin Studies;Viral;viral detection;viral genomics;virome;Virus;Virus Diseases;Work

PROJECT_TITLE: High-resolution, virome-wide infection analysis in type 1 diabetes birth cohorts


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The inhibition of DNA replication initiation is a promising new strategy for cancer therapies, but more research is needed to fully understand mechanisms of replication initiation in metazoans. This project seeks to understand how higher eukaryotes load the replicative helicase Mcm2-7 onto DNA replication origins, and how this process is inhibited by small molecules. This study will provide a greater understanding of molecular mechanisms of DNA replication initiation in higher eukaryotes, which will identify new drug targets and assist in the development of improved DNA replication initiation inhibitors.

PI_NAMEs: HUNKER, OLIVIA  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Amines;Amino Acids;Antineoplastic Agents;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Biophysics;cancer cell;Cancer cell line;cancer therapy;Cells;Clinical;cofactor;Complex;Cryoelectron Microscopy;cytotoxic;cytotoxicity;Data;Development;DNA;DNA Binding;DNA Replication Inhibition;DNA replication origin;drug candidate;Drug Design;drug discovery;Drug resistance;Drug Targeting;drug-like compound;Dwarfism;Eukaryota;Event;Future;Goals;helicase;Human;improved;In Vitro;in vivo;inhibitor;insight;interest;Knowledge;Laboratories;Licensing;Link;Malignant Neoplasms;Mediating;Molecular;mutant;Mutation;Negative Staining;new therapeutic target;novel;novel anticancer drug;origin recognition complex;Pathway interactions;Patient-Focused Outcomes;Peptide Initiation Factors;Physiology;Play;prevent;Process;reconstitution;Replication Initiation;Replication Origin;replication stress;Research;Role;Saccharomyces cerevisiae;Saccharomycetales;Site-Directed Mutagenesis;small molecule;small molecule inhibitor;Structure;System;Testing;Therapeutic;Time;tumor;tumor heterogeneity;X-Ray Crystallography

PROJECT_TITLE: Structural studies of metazoan origin licensing


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Expression of mutant U2AF1(S34F), SF3B1(K700E), or SRSF2(P95H) alters RNA splicing in genetically-engineered mouse models and primary clinical samples, including increased production of nonsense transcripts that rely on nonsense–mediated RNA decay (NMD) for clearance. Our preliminary data suggest that spliceosome mutant cells are more sensitive to NMD inhibition than wild-type cells and the differential sensitivity is partially dependent on excessive R loop formation and DNA damage. Ongoing pre-clinical in vivo efficacy studies will test the potential for SMG1i to treat hematologic malignancies that have splicing factor mutations.

PI_NAMEs: CABRERA, CLAUDIA  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Alternative Splicing;Apoptosis;attenuation;Biological Assay;Biological Markers;Biological Models;Bone Marrow;cancer cell;Cancer cell line;cancer therapy;candidate identification;Cell Death;Cell Line;Cell Survival;cell type;Cells;Chronic Myelomonocytic Leukemia;Clinical;Clonal Hematopoietic Stem Cell;Combined Modality Therapy;Congenic Mice;cytopenia;Data;Development;Disease;DNA;DNA Damage;DNA Repair;Dose;Drug Combinations;Dysmyelopoietic Syndromes;Dysplasia;efficacy study;Engraftment;experimental study;Future;Gene Mutation;gene repair;Genes;Genetically Engineered Mouse;genetically modified cells;Genomic Instability;Goals;Hematologic Neoplasms;Heterozygote;Hybrids;Hypersensitivity;In Vitro;in vivo;in vivo Model;Ineffective Hematopoiesis;inhibitor;innovation;Lead;Malignant Neoplasms;Mammals;Measures;Mediating;Messenger RNA;Modeling;Molecular;Molecular Target;Mus;mutant;Mutant Strains Mice;Mutation;Myeloproliferative disease;novel;novel strategies;novel therapeutic intervention;Pathway interactions;Patients;Pattern;peripheral blood;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacological Treatment;Phosphorylation;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;premature;Prevalence;Process;Production;Proliferating;Protein Isoforms;Protein Kinase;Proteins;Recurrence;Reporting;resistance mechanism;Resolution;RNA;RNA Decay;RNA Helicase;RNA Splicing;Role;Sampling;side effect;Single-Stranded DNA;Spliceosomes;SRSF2 gene;Structure;targeted treatment;Terminator Codon;Testing;Therapeutic;therapeutic evaluation;Transcript;transcriptome sequencing;Translating

PROJECT_TITLE: Targeting Nonsense-Mediated RNA Decay in Splicing Factor Mutant Myeloid Malignancies.


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: ALBANY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: Craniofacial anomalies accounts for one-third of all congenital defects, and are primarily associated with defects in neural crest cells that give rise to most of the craniofacial bone and cartilage. In this project, I will investigate the function and regulation of craniofacial genes by subunits of the global transcription coregulator, Mediator, which will significantly improve our understanding of how ubiquitously expressed proteins control specific developmental processes, potentially providing new therapeutic avenues in the treatment of craniofacial defects.

PI_NAMEs: DASH, SOMA  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Affect;beta catenin;Binding;Binding Proteins;Bioinformatics;Birth;Blood Vessels;bone;Bone Development;Branchial arch structure;Candidate Disease Gene;Cartilage;cartilage development;Cell Communication;Cell Line;Cell Physiology;Cells;Cellular Assay;cellular development;ChIP-seq;Chondrogenesis;chromatin immunoprecipitation;Cleft Palate;Cleidocranial Dysplasia;cofactor;Complex;conditional knockout;Congenital Abnormality;Congenital Disorders;craniofacial;Craniofacial Abnormalities;craniofacial bone;craniofacial development;craniofacial disorder;craniofacial tissue;Data;Defect;Development;developmental disease;Developmental Process;DiGeorge Syndrome;DNA;DNA Binding;Ectoderm;Embryo;Embryonic Development;Endothelial Cells;Enhancers;Ethylnitrosourea;Etiology;Exhibits;Frontonasal Prominence;gene function;Genes;genetic analysis;Genetic Enhancer Element;Genetic Transcription;Germ Layers;Histology;Human;Immunoprecipitation;improved;in vivo;innovation;insight;Jaw;Knowledge;Link;loss of function;Mandible;Mandibulofacial Dysostosis;Mass Spectrum Analysis;Mediating;Mediator;Mesenchyme;Micrognathism;Molecular;Morphogenesis;mouse model;Multiprotein Complexes;Mus;Mutagenesis;mutant;Neural Crest;Neural Crest Cell;neural patterning;neuroregulation;novel;novel therapeutics;Osteogenesis;Pathogenesis;Phenotype;Point Mutation;Pregnancy;protein complex;Proteins;Regulation;Regulator Genes;RNA;RNA Polymerase II;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specificity;Tail;Testing;Tissues;Training;Transcription Coregulator Gene;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;vasculogenesis;Work

PROJECT_TITLE: Functional Characterization of Mediator Complex Proteins in Neural Crest and Craniofacial Development

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: GENETICS

ORG_STATE: PA

PHR: Project Narrative Chromosomes must be equally segregated during cell division or else catastrophic events, such as spontaneous abortion, birth defects, and carcinogenesis, may occur. The chromosomal locus that ensures the equal segregation of chromosomes is the centromere. The goal of this proposal is to elucidate the sequence, structure, and variation of human centromeres and to define their role in ensuring the equal segregation of chromosomes.

PI_NAMEs: LOGSDON, GLENNIS AMELIA (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Advisory Committees;Affect;Aneuploidy;Architecture;Biological Assay;Biological Process;Biological Sciences;Biology;Cancer Etiology;carcinogenesis;career development;Cell division;Cells;Centromere;Chromatin;Chromatin Fiber;chromatin immunoprecipitation;Chromosome abnormality;Chromosome Segregation;Chromosomes;Collaborations;Computing Methodologies;Congenital Abnormality;contig;Data;Defect;Disease;DNA Methylation;Ensure;Environment;Epigenetic Process;epigenetic variation;Event;Exclusion;Foundations;Genetic;genetic information;Genetic Transcription;Genetic Variation;Genomics;Goals;Haplotypes;Health;Human;human model;Individual;innovation;Kinetochores;Knowledge;Life;Location;Malignant Neoplasms;Maps;Mentors;Methods;Microtubules;Modeling;multiple omics;Mutation;nanopore;Nature;NCI Center for Cancer Research;novel;Phase;Population;Positioning Attribute;Postdoctoral Fellow;Process;programs;Protein Isoforms;Research;Research Training;Resources;Rest;Role;Scientist;segregation;skills;Spontaneous abortion;Structure;Tandem Repeat Sequences;Technology;Testing;tool;Training;Transcript;Universities;Untranslated RNA;Variant;Washington;Work

PROJECT_TITLE: Human centromere variation and function