NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PROJECT_TERMS: Angiogenesis Inhibitors;Apoptosis Inhibitor;Bone Marrow Transplantation;Cell Line;Cell Therapy;Cells;Collaborations;conditioning;Cooperative Research and Development Agreement;Disease;DNA;DNA Methyltransferase Inhibitor;Dysmyelopoietic Syndromes;effective therapy;efficacy evaluation;Engraftment;experimental study;FDA approved;Graft-Versus-Tumor Induction;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Histocompatibility;Histone Deacetylase Inhibitor;human disease;IL8RA gene;In Vitro;in vivo;Industry;inhibitor;Institution;Ionizing radiation;kinase inhibitor;Licensing;Manuscripts;MCL1 gene;Minor;Modeling;mouse model;Mus;novel;novel therapeutics;NUP98 gene;Pharmacologic Substance;pre-clinical;pre-clinical assessment;Pre-Clinical Model;preclinical efficacy;preclinical study;Prediction of Response to Therapy;Preparation;Proteins;Publishing;Research Personnel;Role;small molecule;Transgenes;Transplantation;Wild Type Mouse;Xenograft Model

PROJECT_TITLE: Pre-clinical Studies of Therapy for Myelodysplastic Syndrome


ACTIVITY: ZIA

ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases;Skin Cancer;Women's Health Research

ORG_NAME: DIVISION OF BASIC SCIENCES - NCI

PI_NAMEs: ROSENBERG, STEVEN  (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Animal Experiments;Antigens;antitumor effect;Antitumor Response;Autologous;autologous lymphocytes;Autologous Tumor-Infiltrating Lymphocyte;Avidity;bile duct;Bile Duct Carcinoma;Breast;Breast Cancer Patient;Cancer Etiology;cancer immunotherapy;Cancer Patient;cancer regression;cancer therapy;cancer type;Carcinoma;Cell Physiology;Cells;Cervix Uteri;Cessation of life;Clinical Research;Colon;Colorectal;Development;Disease;Disseminated Malignant Neoplasm;Environment;Environmental Monitoring;Esophagus;Evaluation;Exhibits;exome;follow-up;Genes;Human;Immune;immunogenic;Immunologic Tests;Immunotherapy;In Vitro;in vitro testing;in vivo;Infusion procedures;Interleukin-2;KRAS2 gene;Laboratories;Laboratory Research;Laboratory Study;Lymphocyte;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Melanoma;Melanoma patient;Metastatic breast cancer;Metastatic Melanoma;Mus;Mutation;neoantigens;novel strategies;objective response rate;Operative Surgical Procedures;Patient Selection;Patients;pembrolizumab;Peripheral;personalized immunotherapy;Phenotype;phenotypic biomarker;pilot trial;Population;Production;Protocols documentation;Refractory;Renal Carcinoma;Resected;response;Series;Solid Neoplasm;Somatic Mutation;stem;T-Cell Receptor;T-Lymphocyte;TP53 gene;transcriptome sequencing;Translations;tumor;Tumor Antigens;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Adoptive Cell Transfer Immunotherapy of Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases;Skin Cancer

PROJECT_TERMS: Adoptive Transfer;Antigens;Autologous;autologous lymphocytes;B lymphoid malignancy;Cancer Patient;cancer regression;cancer therapy;cancer/testis antigen;Carcinoma;CD19 gene;Cells;cellular transduction;chimeric antigen receptor;Clinical;Clinical Research;Clinical Trials;CTAG1 gene;Development;epidermal growth factor receptor VIII;Epitopes;Gene Library;Gene Modified;gene therapy;Gene Transfer;Genes;Genetic Markers;genetic signature;Germ;Glioblastoma;Human;Immunotherapy;improved;In complete remission;Individual;Inpatients;Kanamycin Kinase;KRAS2 gene;KRASG12D;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;Lymphocyte;MAGEA3 gene;Malignant Neoplasms;Mediating;Melanoma;Melanoma patient;Metastatic Melanoma;MHC antigen;Mutation;neoantigens;novel strategies;Patients;prospective;receptor;Reporting;Resected;response;SILV gene;Solid;Somatic Mutation;stem-like cell;Surface Antigens;synovial sarcoma;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;TP53 gene;transcriptome;tumor;Tumor Antigens

PROJECT_TITLE: Gene therapy of cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Human Genome;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: KHAN, JAVED  (contact)

PROJECT_TERMS: Adoptive Cell Transfers;advanced disease;Antigen Targeting;Antigens;BAY 54-9085;Biological Assay;Calcitonin;CAR T cell therapy;CD276 gene;Cell secretion;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cytotoxicity;Disease;Drug resistance;drug resistance development;Epidermal Growth Factor Receptor;Epigenetic Process;European;exhaustion;exome;Gefitinib;Germ Lines;Glypican;Goals;Imatinib;Immunotherapy;Inherited;inhibitor;KDR gene;Knock-out;Malignant Epithelial Cell;Malignant neoplasm of thyroid;Malignant Neoplasms;Medicine;medullary thyroid carcinoma;Methods;Modeling;Mutation;Neoplasm Metastasis;Neuroblastoma;neuroendocrine cancer;next generation sequencing;novel therapeutics;Operative Surgical Procedures;patient subsets;Patients;Pharmacotherapy;Phase III Clinical Trials;Phosphotransferases;prevent;Protein Tyrosine Kinase;Proteins;Proto-Oncogenes;Resistance;Resistance development;resistance mechanism;Rhabdomyosarcoma;side effect;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;Solid Neoplasm;standard care;Survival Rate;T-Lymphocyte;targeted treatment;Testing;therapy resistant;Thyroidectomy;transcriptome;transcriptome sequencing;Tumor Antigens;Tyrosine Kinase Inhibitor;United States Food and Drug Administration

PROJECT_TITLE: Therapy Resistance Mechanisms for Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Gene Therapy;Genetics;Human Genome;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: Antibodies;Antibody-drug conjugates;ATAC-seq;Binding;Biological Assay;Biophysics;cancer genomics;CAR T cell therapy;CD276 gene;CD28 gene;CD8B1 gene;Cell Line;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials Design;Credentialing;cytokine;cytotoxicity;Development;Docking;effective therapy;efficacy testing;Engineering;Epigenetic Process;Exhibits;Face;fibroblast growth factor receptor 4;FOXO1A gene;Generations;Genes;Genetic;Genetic Transcription;Goals;Growth;Histones;Human;improved;In Vitro;in vivo;inhibiting antibody;inhibitor;KDM1A gene;knock-down;Lysine;Malignant Neoplasms;Modeling;Molecular;Monitor;Monoclonal Antibodies;mouse model;murine monoclonal antibody;Mutate;Mutation;Oncogenes;Oncogenic;Pathway interactions;PAX3 gene;pediatric patients;personalized cancer therapy;Phase I Clinical Trials;Phenocopy;Production;Reagent;Receptor Protein-Tyrosine Kinases;Refractory;Relapse;Rhabdomyosarcoma;small molecule inhibitor;Solubility;Specificity;targeted treatment;Testing;Therapeutic;Tissues;transcription factor;transcriptome sequencing;Transmembrane Domain;treatment strategy;tumor;Tumor Cell Line;Xenograft Model

PROJECT_TITLE: Targeting FGFR4, RAS, and PAX3-FOXO1 gene in Rhabdomyosarcoma


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Clinical Research;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: Alveolar;Artificial Intelligence;Attention;Behavior;Bioinformatics;Biological;Biology;Cancer Biology;Classification;Clinical;clinical risk;Clinical Trials Cooperative Group;Complex;convolutional neural network;Data;Data Set;deep learning;Diagnosis;diagnostic tool;digital;Disease-Free Survival;DNA analysis;DNA copy number;driver mutation;epigenetic profiling;Event;FOXO1A gene;fusion gene;Future;Genetic;Genetic Transcription;genome wide methylation;Germ Lines;Goals;Hematoxylin and Eosin Staining Method;high risk;Histologic;Image;improved;large language model;Lead;Learning;Link;Machine Learning;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;mathematical model;Messenger RNA;Methods;Modeling;Molecular;Morphology;multimodality;Mutation;Neural Network Simulation;Outcome;participant enrollment;Pathway interactions;Patients;PAX3 gene;Pediatric Oncology Group;Performance;Phenotype;predictive modeling;Process;Prognosis;prognostic tool;prospective;protein expression;Proteins;Proteomics;Publishing;Receiver Operating Characteristics;Rhabdomyosarcoma;Risk;risk prediction;risk prediction model;risk stratification;Role;Sampling;single-cell RNA sequencing;Slide;Systems Biology;Techniques;Testing;Time;TP53 gene;Training;transcriptomics;tumor;tumor diagnostic;tumor DNA

PROJECT_TITLE: Bioinformatics, Machine Learning, Systems Biology of Cancers


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Precision Medicine;Rare Diseases

PI_NAMEs: STAUDT, LOUIS  (contact)

PROJECT_TERMS: BCL2 gene;Behavior;biological heterogeneity;Cell Line;Cells;chemotherapy;Classification;Clinical;clinical practice;Clinical Research;Diagnosis;diagnostic platform;Drug Combinations;Drug Targeting;Evaluation;Formalin;Gene Expression;Gene Expression Profile;Genetic;genomic platform;Genomics;Goals;Human;Immuno-Chemotherapy;improved;insight;Investigation;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;Length;lymphoid neoplasm;Lymphoma;Malignant lymphoid neoplasm;Molecular;Molecular Diagnosis;Molecular Profiling;molecular subtypes;Mutation;Oncogenic;Other Genetics;Outcome;outcome prediction;overexpression;Paraffin Embedding;Pathogenesis;Pathway interactions;Patients;Phenotype;Pre-Clinical Model;predicting response;Predisposition;Progression-Free Survivals;Recurrence;Regimen;response;Signal Transduction;Somatic Mutation;targeted agent;Testing;therapeutic target;Tissue Embedding;Toxic effect;Translating;tumor microenvironment

PROJECT_TITLE: Molecular diagnosis and outcome prediction in lymphoma


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PROJECT_TERMS: Address;Antibody-drug conjugates;Autophagocytosis;Binding;cancer cell;cancer survival;cancer type;CD22 gene;Cell membrane;Chronic;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;CRISPR/Cas technology;Dependence;Dose;Drops;Drug Targeting;Enzymes;Essential Genes;functional genomics;Genes;Genetic;Genetic Screening;Genomic approach;Genomics;Glucocorticoid Receptor;Glucocorticoids;glycosylation;Growth;Head;improved;inhibitor;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;Libraries;Link;loss of function;Lymphoid;Lymphoma;Malignant Neoplasms;Mediating;Methodology;Modeling;Molecular Abnormality;Molecular Target;molecular targeted therapies;mutant;new therapeutic target;Newly Diagnosed;novel;Oncogenic;Pathway interactions;Pharmaceutical Preparations;Proliferating;Protein Isoforms;Proteomics;Publishing;Regimen;Regulatory Pathway;Reporting;Resistance;Retroviral Vector;RNA Interference;Role;Sialyltransferases;Signal Pathway;Signal Transduction;small hairpin RNA;src-Family Kinases;superresolution microscopy;System;Taxonomy;Testing;Therapeutic;therapy resistant;Toxic effect;whole genome;Xenograft procedure

PROJECT_TITLE: Functional genomic screens for molecular targets in cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

PROJECT_TERMS: Address;Antibody-drug conjugates;Autophagocytosis;Binding;cancer cell;Candidate Disease Gene;CD22 gene;Cell membrane;Chronic;Clinical Trials;comparative genomic hybridization;Conduct Clinical Trials;Coupled;Credentialing;CRISPR screen;CRISPR/Cas technology;data integration;DNA Resequencing;Drug Targeting;Enzymes;Epigenetic Process;Gene Expression Profiling;Genes;Genetic;Genetic Screening;Genomics;Glucocorticoid Receptor;Glucocorticoids;glycosylation;Goals;Growth;Head;Human;improved;inhibitor;Knowledge;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;Link;Lymphoid;Lymphoma;Lymphoma cell;Malignant Neoplasms;Methods;Molecular;Molecular Target;mutant;new therapeutic target;Newly Diagnosed;novel;Oncogenes;Oncogenic;Pharmaceutical Preparations;Proliferating;Protein Isoforms;Proteomics;Publishing;Recurrence;Regimen;Regulatory Pathway;Reporting;Resistance;RNA Interference;Role;Sampling;Sialyltransferases;Signal Transduction;Somatic Mutation;src-Family Kinases;superresolution microscopy;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic development;Tumor Suppressor Proteins;Xenograft procedure

PROJECT_TITLE: Oncogenic mechanisms and molecular targets in lymphoma


PI_NAMEs: LEVENS, DAVID L. (contact)

PROJECT_TERMS: base;Base Sequence;Binding Sites;Biochemical;Biological;Biophysics;c-myc Genes;Cell Nucleus;Cells;chemotherapeutic agent;Chromatin;Chromatin Structure;computer infrastructure;Coupling;Development;DNA;DNA Probes;DNA Repair;DNA Structure;DNA-Directed RNA Polymerase;druggable target;electrical potential;Elements;enzyme activity;Exposure to;Fiber;flexibility;Gene Expression Regulation;Genes;Genetic;Genetic Processes;Genetic Recombination;genetic regulatory protein;Genetic Transcription;Genome;Genome Mappings;genome-wide;H-DNA;in vivo;Individual;Knowledge;Left;Literature;Malignant Neoplasms;Maps;Measures;mechanical force;Mechanics;Medical;melting;meter;Methods;Modification;Molecular Conformation;Molecular Machines;nanopore;neural network;novel strategies;Nucleic Acids;Oncogenes;Other Genetics;Pathologic;Pattern;Penetration;permanganate;Physiological;Population;Potassium Permanganate;Predisposition;Process;promoter;Regulatory Element;Relaxation;Resolution;Role;Signal Transduction;single molecule;Single-Stranded DNA;Site;Stress;Stretching;Structure;Topoisomerase;Topoisomerase Inhibitors;Torque;Transcription Process;transmission process;virtual;whole genome;Work;Z-Form DNA

PROJECT_TITLE: The genome-wide function of supercoiling and alternative DNA conformations


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Kidney Disease;Orphan Drug;Rare Diseases

PI_NAMEs: LINEHAN, WILLIAM MARSTON (contact)

PROJECT_TERMS: Adrenal Gland Neoplasms;Adrenal Glands;Affect;American;Bilateral;Blood Tests;Brain Neoplasms;cancer type;Chromosome 17;Chromosome 3;Chromosome 7;Chromosome Arm;Chromosome Mapping;Clear Cell;Clinical;clinical diagnosis;Clinical Management;Clinical Research;Clinical Trials;Complex;Conventional (Clear Cell) Renal Cell Carcinoma;Cytogenetics;Defect;design;Detection;Development;Diagnosis;Disease;Ear Neoplasms;Event;Eye;Family;Family Study;Foundations;Fumarate Hydratase;Gene Mutation;Genes;Genetic;genetic linkage analysis;Genetic study;genetic testing;Genomics;Genotype;Germ Lines;Germ-Line Mutation;Hereditary Leiomyomatosis and Renal Cell Cancer;Hereditary Papillary Renal Carcinoma;Histology;Hybrids;Iceland;improved;Individual;Inherited;Kidney;Kidney Neoplasms;kindred;Laboratories;Labyrinth;Leiomyomatosis;Malignant Neoplasms;member;MET gene;Methods;Methylation;minimally invasive;Molecular Genetics;Mutation;Mutation Detection;New Agents;new therapeutic target;novel;Oncogenes;Oxyphil Cells;Pancreas;pancreatic neoplasm;Papillary;Pathology;Pathway interactions;Patients;Pattern;Phenotype;Pheochromocytoma;preclinical study;Proto-Oncogenes;Renal Carcinoma;Reporting;Research Personnel;Risk;Running;Series;Somatic Mutation;Spinal Neoplasms;Surgical Management;Syndrome;targeted treatment;tumor;Tumor Suppressor Genes;Tyrosine Kinase Domain;United States National Institutes of Health;Vertebral column;VHL gene;VHL mutation;Von Hippel-Lindau Syndrome;Work;working group

PROJECT_TITLE: Clinical Studies of the Molecular Genetic Basis of Kidney Cancer


NIH_SPENDING_CATS: Cancer

PI_NAMEs: NECKERS, LEONARD  (contact)

PROJECT_TERMS: Acetylation;Affect;Antibodies;Appearance;Bypass;C-terminal;cancer cell;CDC37 homolog protein;Cells;Characteristics;Client;Complex;Data;Data Set;Dimerization;Docking;drug efficacy;Enzymes;Eukaryota;Glycolysis;Heat-Shock Proteins 90;Human;in vivo;Lysine;Maps;Mass Spectrum Analysis;Mediating;Metabolic;mimetics;Mitochondria;Modification;Molecular Chaperones;Molecular Conformation;Mutation;N Domain;neoplastic cell;Normal Cell;novel;Nutrient availability;Oncogenic;overexpression;Phosphopeptides;Phosphorylation;Phosphotransferases;Population;Post-Translational Modification Site;Post-Translational Protein Processing;Process;programs;Protein Kinase;Protein Tyrosine Kinase;Proteins;Publishing;recruit;Recycling;Reporting;Shapes;Site;Specificity;src Homology Region 2 Domain;Sumoylation Pathway;System;targeted treatment;Tumor Escape;Tyrosine;Tyrosine Phosphorylation;Yeasts

PROJECT_TITLE: Post-translational modifications of Hsp90


PI_NAMEs: ROCHE, PAUL  (contact)

PROJECT_TERMS: Antigens;CD8-Positive T-Lymphocytes;Cell membrane;Cells;Cross Presentation;Endosomes;Event;Exocytosis;Hematopoietic;Immune;Lysosomes;mast cell;Membrane;Membrane Fusion;Molecular;Mus;Names;Organelles;Phagosomes;Phosphorylation;Process;Proteins;Recycling;Regulation of Exocytosis;Role;Secretory Vesicles;SNAP receptor;SNAP23 gene;Surface;trafficking

PROJECT_TITLE: Regulation of Exocytosis from Immune Cells


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Kidney Disease;Orphan Drug;Rare Diseases

PROJECT_TERMS: 2019-nCoV;Affect;American;beta catenin;Binding;Cancer Etiology;Cancer Model;cancer type;Catalytic Domain;Cell Culture Techniques;Cell Line;Citric Acid Cycle;Clear Cell;Clear cell renal cell carcinoma;Clinical;Clinical Trials;cofactor;Complex;Conventional (Clear Cell) Renal Cell Carcinoma;COVID-19 treatment;Cryoelectron Microscopy;Cutaneous Leiomyoma;Development;Disease;elongin B;elongin C;Enzymes;Family;Foundations;Fumarate Hydratase;Fumarates;Geldanamycin Analogue;Genes;Genetic Transcription;Genome;Germ Lines;Goals;Growth;Heat-Shock Proteins 90;helicase;Hereditary Leiomyomatosis and Renal Cell Cancer;Hereditary Neoplastic Syndromes;Histology;Human;Hypoxia;Hypoxia Inducible Factor;In Vitro;in vitro Model;in vivo;Individual;Inherited;Iron;Kidney Neoplasms;Ligation;Loss of Heterozygosity;Malignant Neoplasms;Mediating;MET gene;Metal Binding Site;Metals;Modeling;Molecular;Mutate;Mutation;New Agents;novel;Oncogenes;oxidation;Papillary;Pathway interactions;Patients;Platelet-Derived Growth Factor;prevent;Process;Procollagen-Proline Dioxygenase;Proteins;receptor;Renal Carcinoma;Renal Cell Carcinoma;Risk;RNA-Directed RNA Polymerase;Role;SARS-CoV-2 antiviral;SARS-CoV-2 inhibitor;Scientist;Site;Small Interfering RNA;Stains;Structure;Sulfur;System;targeted agent;targeted treatment;tempol;Therapeutic;transcription factor;Transforming Growth Factor alpha;Translations;tumor;Tumor Tissue;Ubiquitin;Urologic Oncology;Uterine Fibroids;Vascular Endothelial Growth Factors;VHL gene;VHL protein;Viral;Von Hippel-Lindau Syndrome;Work;Zinc

PROJECT_TITLE: Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene


PROJECT_TERMS: Affect;American;Animal Model;Animals;Area;Binding;Binding Proteins;Cancer cell line;Cancer Etiology;cancer type;Cell Surface Receptors;Cells;Clear Cell;Clear cell renal cell carcinoma;Clinical;Code;Cutaneous;Cyst;Cystic kidney;Cytoplasm;Development;Disease;Evaluation;Family;Folliculin;Foundations;Frameshift Mutation;Genes;Germ Lines;Germ-Line Mutation;Growth Factor;Hereditary Neoplastic Syndromes;Hereditary Papillary Renal Carcinoma;HGF gene;Histology;Human;Hybrids;Hyperplasia;In Vitro;in vitro Model;in vivo;Inherited;Kidney;Kidney Neoplasms;kindred;Knockout Mice;loss of function;Loss of Heterozygosity;Lung;MET gene;MET Gene Mutation;MET Oncogene;Modeling;Molecular;Mus;Mutation;New Agents;Nonsense Mutation;novel;Oncogenes;Oxyphil Cells;Papillary;Pathway interactions;patient subsets;Patients;Phenotype;Phosphorylation;Protein Truncation;Proteins;receptor;Renal Carcinoma;Renal Cell Carcinoma;Risk;Role;Sampling;Sirolimus;Somatic Mutation;Specimen;Syndrome;targeted agent;targeted treatment;Testing;Therapeutic;Tissues;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;Tyrosine Kinase Domain;VHL gene;Work

PROJECT_TITLE: Molecular Therapeutics of Kidney Cancer: MET Gene and BHD Gene


PI_NAMEs: GILDERSLEEVE, JEFFREY  (contact)

PROJECT_TERMS: Antibodies;Antigens;Area;Binding;Biological Assay;Biological Markers;cancer biomarkers;cancer diagnosis;cancer therapy;Cancer Vaccines;Carbohydrates;carcinogenesis;COVID-19 patient;Detection;Disease;Goals;Human;Immune response;improved;Malignant Neoplasms;Measures;Monitor;Patients;Play;Polysaccharides;Prognosis;Proteins;Research;response;Role;Serum;Technology;treatment response;vaccine immunogenicity;Vaccines

PROJECT_TITLE: Serum Antibody Profiling with a Carbohydrate Microarray


PI_NAMEs: MOCK, BEVERLY  (contact)

PROJECT_TERMS: Chromosome 1;Distal;Genes;genetic linkage analysis;genome-wide linkage;Human;interest;Interferons;Maps;Mass Spectrum Analysis;Microarray Analysis;Mus;Plasmacytoma;Predisposition;Proteins;Regulation

PROJECT_TITLE: A Modifier of Plasmacytoma Susceptibility Maps to Mouse Chr 1


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PROJECT_TERMS: Affect;Animal Model;cancer therapy;Cell Cycle;Cell Line;Combined Modality Therapy;Drug Combinations;Drug Synergism;drug testing;FBXW7 gene;FRAP1 gene;Future;Genetic Predisposition to Disease;Goals;head-to-head comparison;Histone Deacetylase;Histone Deacetylase Inhibitor;Histones;Immunocompetent;inhibitor;Malignant Neoplasms;mTOR Inhibitor;Mus;Mutation;MYC Family Protein;Non-Hodgkin's Lymphoma;Oncogenes;Pathway interactions;Pharmaceutical Preparations;Plasma Cell Neoplasm;preclinical evaluation;preclinical study;Preclinical Testing;Signal Pathway;Signal Transduction Pathway;Sirolimus;targeted treatment;Testing;tissue/cell culture;tumor;Tumor Cell Line;Tumor Suppressor Proteins;Work

PROJECT_TITLE: Preclinical Testing of Drug Combinations (HDAC, mTOR, CDK and MYC Inhibitors)


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Hodgkin's Disease;Infectious Diseases;Lymphatic Research;Lymphoma;Pediatric;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: JAFFE, ELAINE  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adopted;Adult;age group;Area;Autoimmune Diseases;B-Cell Lymphomas;B-Lymphocytes;Basic Science;Cell Differentiation process;Cell Physiology;Childhood;Classification;Clinical;clinical diagnosis;clinical practice;Clinical Protocols;Clinical Research;Communities;congenital immunodeficiency;Consultations;Dendritic Cells;Development;Diagnosis;Diagnostic;Diagnostic Services;Disease;disease classification;Education;Extranodal;Genes;Goals;Growth;Hematologic Neoplasms;Hematopathology;histiocyte;Histiocytosis;Hodgkin Disease;Human Herpesvirus 4;Human Herpesvirus 8;Hyperplasia;immunodeficiency;Immunohistochemistry;Immunologic Deficiency Syndromes;improved;In Situ Hybridization;in vivo;Institution;International;Ki-1 Large-Cell Lymphoma;Knowledge;Laboratories;Lesion;leukemia/lymphoma;Lymphoblastic Leukemia;Lymphocyte Function;Lymphoid;Lymphoid Cell;lymphoid neoplasm;Lymphoma;Lymphoproliferative Disorders;Malignant lymphoid neoplasm;Mission;Molecular;molecular diagnostics;Multicentric Angiofollicular Lymphoid Hyperplasia;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;Neoplasms;neoplastic;Nodal;novel;Panniculitis;Pathogenesis;Pathologic;Pathologist;Pathology;Patients;Phenotype;Physicians;Physiology;programs;Proliferating;promoter;Publications;Rare Diseases;Reproducibility;Research;Second Opinions;Services;Standardization;subcutaneous;symposium;synergism;T-Cell and NK-Cell Neoplasm;T-Cell Lymphoma;T-Lymphocyte;tool;Training;translational study;Uncertainty;United States National Institutes of Health;Work

PROJECT_TITLE: Hematopathology Diagnosis


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Rare Diseases

PI_NAMEs: DOROSHOW, JAMES  (contact)

PROJECT_TERMS: Alveolar Soft Part Sarcoma;CCR;clinical development;Clinical Trials;Development;Developmental Therapeutics Program;Disease;Division of Cancer Treatment and Diagnosis;early phase trial;first-in-human;Goals;inhibitor;insight;Kidney;leiomyosarcoma;Molecular;novel anticancer drug;novel therapeutics;Paclitaxel;Pharmacodynamics;pharmacologic;Phase;rapid diagnosis;rare cancer;Solid Neoplasm;System;Systemic Therapy;Therapeutic Agents;Toxic effect;young adult

PROJECT_TITLE: Phase 0-1 Clinical Trials


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Prevention;Prostate Cancer;Urologic Diseases

PI_NAMEs: PINTO, PETER  (contact)

PROJECT_TERMS: Achievement;Adoption;advanced prostate cancer;Artificial Intelligence;bench to bedside;Biopsy;Caring;CCR;Clinical;Clinical Trials;commercialization;computer aided detection;deep learning;Detection;Development;Diagnosis;Disease;Evidence based practice;Expression Profiling;Gleason Grade for Prostate Cancer;Goals;Image;Image-Guided Surgery;Imaging Device;improved;Journals;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Medicine;metabolomics;Methods;multidisciplinary;novel;novel strategies;Pathology;Pathway interactions;Patient Care;Patients;programs;Prostate;Reporting;Research;Screening for Prostate Cancer;System;Techniques;Therapeutic;Tissues;Translations;tumor;United States National Institutes of Health;Urology;Work

PROJECT_TITLE: Prostate Section


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Urologic Diseases

PI_NAMEs: BUCK, CHRISTOPHER  (contact)

PROJECT_TERMS: Adenoviruses;Affect;Animals;Antibodies;Arachnida;Basic Science;Bioinformatics;BK Virus;clinical center;Collaborations;Data Set;deep sequencing;Deposition;Distant;Division of Cancer Epidemiology and Genetics;DNA Viruses;Exanthema;Family;Goals;Human;Human Biology;Immunity;immunosuppressed;Individual;Investigation;JC Virus;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mission;Molecular Biology;Names;neutralizing monoclonal antibodies;organ transplant recipient;Papillomavirus;Parvovirus;Peer Review;Perception;Play;Polyomavirus;precursor cell;prevent;Process;Proteins;Pruritus;public database;receptor;Recombinants;Recording of previous events;Retroviridae;Risk;Role;Testing;tumor;United States National Institutes of Health;vaccine development;Virion;Virus;Work

PROJECT_TITLE: Molecular biology of human polyomaviruses


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Rare Diseases

PI_NAMEs: MELTZER, PAUL S. (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;analytical method;Animal Model;Base Sequence;Basic Science;Bioinformatics;Biology;Cancer Biology;cancer cell;cancer genome;cancer genomics;Cell Line;Cells;Chromatin;chromatin modification;Chromosomes;Classification;Clinical;Clinical Research;Code;Communities;Complex;computational pipelines;Computing Methodologies;cost effective;Data;Development;DNA;DNA copy number;DNA Methylation;DNA Microarray Chip;DNA Sequence;DNA Sequence Alteration;Epigenetic Process;Fine needle aspiration biopsy;Formalin;Future;Gastrointestinal Stromal Tumors;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;genome-wide analysis;Genomic Instability;genomic profiling;Glioma;Goals;Growth;Harvest;Hematologic Neoplasms;Hospitals;Human;Human Genome;improved;Industrialization;inhibitor;interest;Laboratories;Length;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Measurement;Measures;medullary thyroid carcinoma;Methodology;Methods;Modeling;mouse model;multidisciplinary;multiple omics;Mutation;Mutation Detection;new technology;next generation sequence data;novel;novel strategies;Paraffin Embedding;Pathology;Pathway interactions;pediatric patients;premalignant;Process;Protocols documentation;Repetitive Sequence;Research;Role;Sampling;Scientist;Single Nucleotide Polymorphism;Site;Small RNA;Solid Neoplasm;Sorting;Specialist;Specimen;Structure;Technology;technology development;telomere;Testing;Tissue Sample;Tissues;tool;transcription factor;Transferase;Translational Research;tumor;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Cancer Genomics Technology Development


NIH_SPENDING_CATS: Cancer;Pediatric

PI_NAMEs: MORRISON, DEBORAH  (contact)

PROJECT_TERMS: Adhesiveness;Behavior;Binding;Binding Sites;Biological;Caenorhabditis elegans;Catalytic Domain;cell motility;Cell surface;Cell-Cell Adhesion;Cells;Cellular Structures;CNKSR1 gene;Complex;Cues;Defect;Development;developmental disease;Disease;E-Cadherin;Enhancers;Event;experimental study;extracellular;Family;Family member;gain of function;gastrulation;genetic regulatory protein;Genetic Screening;Germ-Line Mutation;Goals;GTP Binding;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Hippocampus;human embryonic development;insight;Insulin Signaling Pathway;Intercellular Junctions;Laboratories;Mediating;member;Molecular;Molecular Conformation;Morphogenesis;MRAS gene;mutant;Neurons;Noonan Syndrome;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphotransferases;Play;Process;Protein Dephosphorylation;Protein Family;Protein phosphatase;Proteins;raf Kinases;ras Proteins;Ras Signaling Pathway;reconstitution;Regulation;Reporting;Research;response;Role;scaffold;Scaffolding Protein;Signal Pathway;Signal Transduction;tumor;Vertebral column;Work;Zebrafish

PROJECT_TITLE: Role of Protein Scaffolds in RTK-Ras-dependent Signal Transduction


PI_NAMEs: SINGER, ALFRED  (contact)

PROJECT_TERMS: Agonist;Autoimmunity;autoreactive T cell;autoreactivity;CD4 Positive T Lymphocytes;Cells;Clonal Deletion;Development;effector T cell;FOXP3 gene;IL2RA gene;Immune;in vivo;Interleukin-2;prevent;Receptor Signaling;Regulatory T-Lymphocyte;Signal Induction;Signal Transduction;T-Cell Receptor;thymocyte;Thymus Gland;Transforming Growth Factor beta

PROJECT_TITLE: Development and function of regulatory T cells


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Lung;Lung Cancer;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

PI_NAMEs: SCHRUMP, DAVID  (contact)

PROJECT_TERMS: Aerodigestive Tract;Affect;Agreement;airway epithelium;Asbestos;Automobile Driving;Bioinformatics;Biological Assay;Biopsy;Blood specimen;cancer cell;Cancer Center;cancer therapy;carcinogenesis;Cell Culture Techniques;Cell Separation;Cells;cigarette smoke;cigarette smoking;Clinical;clinically relevant;Code;cohort;Collaborations;Complementary DNA;crosslink;Development;Digestion;Dilution Techniques;Dimethyl Sulfoxide;DNA;DNA Methylation;DNA Modification Methylases;DNMT3B gene;Dose;Down-Regulation;Enhancers;Environmental Carcinogens;Epigenetic Process;epigenomics;Epithelial Cells;esophageal carcinogenesis;Event;experimental study;Exposure to;exposure to cigarette smoke;EZH2 gene;Family;Fiber;Fibroblasts;FVB Mouse;Gene Chips;Gene Expression;Gene Expression Profile;Gene Silencing;Genes;genetic pedigree;Genomics;Germ Lines;Growth;Hawaii;Human;I-kappa B Proteins;Image;Immunoprecipitation;In Vitro;in vitro Model;in vivo;Invaded;Link;Lung;lung cancer cell;Malignant - descriptor;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of thorax;Malignant Neoplasms;Malignant Pleural Mesothelioma;Manuscripts;Mediating;Mesothelial Cell;Mesothelioma;Mus;Mutation;Neoplasms;NF-kappa B;Normal Cell;Normal tissue morphology;novel;novel strategies;Oncogenes;Patients;Peer Review;pharmacologic;Phenotype;Physical condensation;Pleural;Pleural Mesothelial Cell;Plicamycin;Polycomb;Preparation;Prevention;Primary Neoplasm;promoter;prospective;Proteins;Protocols documentation;Publishing;Quantitative Reverse Transcriptase PCR;RB1 gene;Recording of previous events;Records;recruit;repository;Repression;Resources;RNA;Serum;Signal Transduction;skin biopsy;SP1 gene;Specimen;stemness;Stream;Syndrome;Techniques;Tetanus Helper Peptide;Tissue Sample;Tobacco;treatment strategy;tumor;Tumor Suppressor Proteins;Universities;Untranslated RNA;Up-Regulation;virtual;Western Blotting;Xenograft Model

PROJECT_TITLE: Epigenetic Mechanisms of Gene Expression in Thoracic Malignancies


PROJECT_TERMS: Antibodies;Antigen Presentation;Antigens;Detection;Generations;Goals;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Molecular;molecular shape;Reaction;receptor;receptor binding;T-Cell Receptor;T-Lymphocyte;Thymus Gland

PROJECT_TITLE: MHC-independent T cells


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: MACKEM, SUSAN  (contact)

PROJECT_TERMS: Adult;Affect;Anterior;Apoptosis;Apoptotic;autocrine;Autocrine Communication;Basal Cell Nevus Syndrome;Biological Assay;Body System;Brain;Bypass;cancer type;cell behavior;Cell Death;cell motility;Cell Physiology;Cell Proliferation;Cell Survival;Cells;cellular targeting;Cessation of life;Child;Code;Communities;Complement component C5;Complementary DNA;Complex;Coupled;design;Development;Developmental Biology;developmental genetics;Digit structure;Elements;Embryo;Ensure;Enterobacteria phage P1 Cre recombinase;ERG gene;Exons;Family member;Feedback;Fibroblast Growth Factor;Fingers;Gene Deletion;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;Genetic Diseases;Genetic Transcription;genome-wide;Genomics;Goals;Growth;Holoprosencephaly;Hour;Human;Infant;insight;Intercept;Joints;Learning;Length;Ligands;Limb Bud;Limb Development;Limb structure;Link;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;Mesoderm;Mitogens;model building;Modeling;Morbidity - disease rate;Morphogenesis;morphogens;mortality;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Neoplasm Metastasis;Neoplasms;neoplastic cell;Neural Crest;Normal tissue morphology;novel;Nucleic Acid Regulatory Sequences;Organ;Pancreas;paracrine;Pathologic;Pathology;Pathway interactions;Pattern;Phalanx;Phase;Physiological Processes;Play;Process;Production;progenitor;Proliferating;Prostate;Proteomics;Refractory;Regulation;Reporter;response;Role;selective expression;Shapes;SHH gene;Signal Pathway;Signal Transduction;Skeleton;Skin;smoothened signaling pathway;Sonic Hedgehog Pathway;Specific qualifier value;stem cell population;Stomach;Structure;Study models;System;Systems Biology;Tamoxifen;Testing;Therapeutic Intervention;Thumb structure;Time;tissue regeneration;Tissues;tool;transcription factor;transcriptome;transcriptomic profiling;transcriptomics;Transgenes;Transgenic Mice;tumor;Tumor Biology;tumorigenesis

PROJECT_TITLE: Role of Shh in developmental patterning and growth of digit skeleton


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PROJECT_TERMS: Adult;Ambystoma;Amphibia;Amputation;Anterior;Appearance;ATAC-seq;beta catenin;Cartilage;Cell Adhesion;cell behavior;Cell Death;cell motility;Cell Physiology;Cells;cellular targeting;Cessation of life;Chick;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Congenital Abnormality;Data;design;Development;Developmental Biology;digit regeneration;Digit structure;Disease;Distal;Elements;Embryo;Ensure;Equilibrium;Erinaceidae;Evolution;Excision;Feedback;Fibroblast Growth Factor;Finger joint structure;Fingers;gastrointestinal epithelium;Gene Dosage;Gene Expression Profiling;Gene Expression Regulation;Gene Targeting;Genes;Genetic;genetic approach;Genetic Transcription;Genomics;GLI3 gene;Goals;Growth;Hindlimb;Homeobox;Homeobox Genes;Homeostasis;Human;in vivo;insight;Intercept;joint formation;Joints;knock-down;Learning;Length;Limb Bud;Limb Development;limb regeneration;Limb structure;Link;Maintenance;Malignant Neoplasms;Mammals;Mesenchyme;Methods;model building;Morphogenesis;Morphology;Mus;mutant;Neoplasm Metastasis;Neoplasms;neoplastic;neoplastic cell;Organ;Organ Culture Techniques;Output;Pathogenesis;Pathologic;Pathology;Pathway interactions;Pattern;Periodicals;Phalanx;Phalanx of hand;Physical condensation;Physiological Processes;Play;Positioning Attribute;postnatal;Process;progenitor;Proliferating;Proteins;Proteomics;Radial;regeneration potential;Regenerative capacity;Regulation;Replication Licensing;Role;Running;Shapes;SHH gene;Signal Induction;Signal Transduction;Site;skeletal;skeletal regeneration;Skeleton;Skin;smoothened signaling pathway;Sonic Hedgehog Pathway;stem cells;Structure;Study models;System;Systems Biology;Testing;Thumb structure;Tissues;transcription factor;transcriptome;Tumor Biology;tumorigenesis;ulna;Vertebrates;Work

PROJECT_TITLE: Late stage signaling centers and Gli3-Hoxd interaction roles in Hedgehog regulated digit morphogenesis


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric

PROJECT_TERMS: Adult;Apoptotic;bone morphogenetic protein receptors;Bypass;cell behavior;Cell Death;cell motility;Cell Physiology;Cell Survival;Cells;cellular targeting;Cessation of life;ChIP-seq;chromatin immunoprecipitation;Complex;conditional mutant;derepression;design;Development;Developmental Biology;Digit structure;Ectoderm;Elements;Embryo;Ensure;ERG gene;Erinaceidae;Feedback;Fibroblast Growth Factor;Fingers;Foundations;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;genetic approach;Genetic Diseases;Genetic study;Genetic Transcription;genome-wide;Genomics;GLI gene;Goals;Growth;Homeobox Genes;Homeostasis;Human;insight;Intercept;Joints;Knock-out;Learning;Length;Limb Bud;Limb Development;Limb structure;Link;LoxP-flanked allele;Malignant Neoplasms;Mediating;Minor;model building;Modeling;Molecular;Molecular Genetics;Morphogenesis;morphogens;mutant;Mutant Strains Mice;Mutate;Neoplasm Metastasis;Neoplasms;neoplastic cell;Organ;Organogenesis;Pathogenesis;Pathologic;Pathology;Pathway interactions;Pattern;Phalanx;Phase;Physiological Processes;Play;Process;Proliferating;Proteomics;Regulation;response;Role;Secondary to;self-renewal;Shapes;SHH gene;Signal Pathway;Signal Transduction;Skeleton;Skin;Specific qualifier value;Structure;Study models;Supporting Cell;System;Systems Biology;three dimensional structure;Thumb structure;Tissues;transcription factor;transcriptome;transcriptome sequencing;transcriptomic profiling;Tumor Biology;tumorigenesis

PROJECT_TITLE: Genome-wide target analysis of Shh-activated transcription network in limb bud


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Genetics;HIV/AIDS;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

PI_NAMEs: FRANCHINI, GENOVEFFA  (contact)

PROJECT_TERMS: 5'-Nucleotidase;Accounting;Adenosine;Adjuvant;adolescent woman;Affect;Africa South of the Sahara;aged;Aging;aluminum sulfate;ALVAC;Animal Model;animal old age;Animals;Anti-Inflammatory Agents;Antibodies;antibody-dependent cell cytotoxicity;antigen binding;Antigens;Apoptosis;Apoptotic;Binding;CCL2 gene;CCR5 gene;CD14 gene;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Chimeric Proteins;Chromatin;chronic infection;Clinical;cohort;Combined Vaccines;Complex;Contralateral;CREB1 gene;Cryopreservation;Dendritic Cells;design;Development;DNA;Dose;env Gene Products;Enzymes;Epidemic;epigenetic marker;Female Adolescents;first-in-human;Frequencies;Functional impairment;Futility;Gel;HIV;HIV Envelope Protein gp120;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;HIV-1;HIV-infected adolescents;HIV/SIV vaccine;Human;Human Volunteers;Hydroxides;IL17 gene;IL18 gene;Immune;Immunity;Immunization;Immunize;immunogenicity;Incidence;Infection;infection risk;Inflammasome;inhibitor;Insulin-Like Growth Factor I;Interferon Type II;Interleukin-10;Limb structure;Macaca;Macrophage;Mediating;men;MF59;Modality;Modeling;Molecular Conformation;Monoclonal Antibodies;monocyte;monomer;mRNA delivery;Mucosal Immune Responses;Mucosal Immunity;mucosal site;Mucous Membrane;Myelogenous;Myeloid Cells;natural killer cell protein 44-kDa;Natural Killer Cells;NIH Office of AIDS Research;novel vaccines;Nucleocapsid Proteins;Pathogenicity;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Phase;phase I trial;Phase III Clinical Trials;Plasma;plasmid DNA;Population;poxvirus vectors;pre-clinical;Predisposition;Proteins;rational design;Recombinants;Regimen;Reproducibility;Research Institute;Resolution;Resources;response;Risk;RNA vaccine;Role;safety testing;Sampling;Shapes;SIV;social;South Africa;South African;spatial relationship;synergism;T cell response;T-Lymphocyte;Testing;Topical application;Transcript;transcriptome;transcriptome sequencing;Translating;Vaccinated;Vaccination;vaccine candidate;vaccine development;vaccine efficacy;vaccine evaluation;vaccine response;vaccine trial;Vaccines;Vaginal Ring;Variant;virucide;Virus;Virus-like particle;Whole Blood;Woman;Work;Zinc;Zinc Fingers

PROJECT_TITLE: Development of rationally designed HIV vaccines


PI_NAMEs: BYRD, ROBERT  (contact)

PROJECT_TERMS: Bacteria;Biophysics;Cells;Collaborations;Complex;design;Disease;Endoplasmic Reticulum;Enzymes;Evaluation;Family;Genetic;Homeostasis;Human;Infection;interest;Intervention;Investigation;Knowledge;Laboratories;Malignant Neoplasms;member;Membrane;Methods;Molecular Conformation;molecular recognition;multicatalytic endopeptidase complex;multidisciplinary;Neoplasm Metastasis;NMR Spectroscopy;Pathogenicity;Pathway interactions;Process;protein complex;protein degradation;protein protein interaction;Proteins;Protocols documentation;Reaction;receptor;Regulation;Research;Specificity;structural biology;Structure;Substrate Specificity;Therapeutic;tumor;UBE2G2 gene;Ubiquitin;Ubiquitin-Conjugating Enzymes;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Investigation of Protein-Protein Interactions in the ERAD Ubiquitylation Pathway


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PROJECT_TERMS: Address;Area;Binding;biophysical techniques;Biophysics;Complex;Development;Dissection;Enzymes;Equilibrium;Event;experimental study;Guanosine Triphosphate;Isotope Labeling;Measurement;Membrane;Membrane Proteins;method development;Methodology;Methods;mimetics;Molecular Conformation;molecular dynamics;Molecular Structure;Monitor;Monomeric GTP-Binding Proteins;nanodisk;Neutrons;novel;novel strategies;Pathway interactions;Process;protein complex;Protein Engineering;Protein Family;protein protein interaction;Proteins;Relaxation;Roentgen Rays;side effect;Signal Transduction;small molecule inhibitor;structural biology;Structure;Surface;System;Technology;Therapeutic;therapeutic development;tool;Ubiquitination

PROJECT_TITLE: Methods Development


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Digestive Diseases;Inflammatory Bowel Disease

PI_NAMEs: DURUM, SCOTT  (contact)

PROJECT_TITLE: Chronic Inflammation and Carcinogenesis


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Immunotherapy;Infectious Diseases

PI_NAMEs: TRINCHIERI, GIORGIO  (contact)

PROJECT_TERMS: adaptive immune response;adaptive immunity;Apoptosis;Area;ATAC-seq;Autoimmune Diseases;Autoimmunity;Biological Response Modifiers;cancer immunotherapy;cancer prevention;Categories;Cell Differentiation process;Cell Physiology;Cells;Classification;Complex;Connective Tissue;cytokine;Data;Data Set;Degenerative Disorder;Dendritic cell activation;Dendritic Cells;Disease;Epithelial Cells;Epithelium;Experimental Models;falls;Family;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Genome;Goals;Helper-Inducer T-Lymphocyte;Homeostasis;Human;human disease;IL17 gene;Immune;Immune response;Immune system;immunopathology;Immunotherapy;Infection;Inflammation;Inflammation Mediators;Inflammatory;Innate Immune Response;Interferon Type I;Interleukin-1 beta;interleukin-23;Lectin Receptors;Ligands;Lymphocyte;Malignant Neoplasms;Mastigophora;Mediating;microbial;microbiome;microorganism;Molecular;Mouth Diseases;Mucous Membrane;Natural Immunity;Nature;neoplastic cell;novel;Oral mucous membrane structure;Pathogenicity;Pathology;Patients;Pattern recognition receptor;Periodontitis;polarized cell;Production;Proliferating;Published Comment;receptor;Regulation;response;Role;Signal Transduction;single-cell RNA sequencing;Surface;synergism;System;T-Cell Activation;T-Lymphocyte Subsets;Time;Tissues;TLR5 gene;Toll-like receptors;Transcriptional Regulation;transcriptome;Vaccines;Work

PROJECT_TITLE: Regulation of human dendritic cell activation


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Complementary and Integrative Health;Genetics;HIV/AIDS;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Microbiome;Nutrition;Prevention;Skin Cancer;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Actinobacteria class;Adverse event;Adverse reactions;Affect;Agonist;Animals;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;Antibiotic Therapy;Antibiotics;arm;Bacteria;Bacteroidetes;biological systems;Birth;Cancer Control;cancer immunotherapy;Cancer Patient;cancer type;carcinogenesis;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Proliferation;Cells;chemotherapy;Chemotherapy-Oncologic Procedure;Chronic;Clinical;cohort;commensal bacteria;Communication;Communities;comorbidity;Complex;CPG-oligonucleotide;Crohn's disease;cytokine;Cytotoxic T-Lymphocytes;Data;data integration;Dendritic Cells;Development;Diet;Dietary Fiber;Disease;Distal;efficacy evaluation;Enterobacteriaceae;Epithelium;Etiology;Eukaryota;Evaluable Disease;Exposure to;Familiarity;Family;fecal microbiota;Fiber;Firmicutes;Fortification;Frequencies;Genes;Genetic;genetic signature;genotoxicity;Germ-Free;Gnotobiotic;Gram-Negative Bacteria;gut microbes;gut microbiome;gut microbiota;Health;Hemorrhage;high risk;Homeostasis;host microbiota;Human;Human body;Human Microbiome;Immune;immune activation;Immune response;Immune system;Immunity;immunodeficiency;Immunotherapy;Impairment;improved;Individual;Infiltration;Inflammation;Inflammatory Response;Intake;Interferons;Invaded;Laboratories;Lung;Macrophage Activation;Maintenance;Malignant Neoplasms;Mediating;Melanoma;Melanoma patient;member;Metabolic Control;Metabolism;Methods;Microbe;microbial;microbiome;microbiome composition;microbiota;microbiota composition;microorganism;migration;Modification;Molecular;monocyte;mouse model;Multiomic Data;multiple omics;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Necrosis;Neoadjuvant Study;Neoadjuvant Therapy;Nivolumab;Outcome;pathogen;pathogenic microbe;Pathologic;Pathway Analysis;Patients;Pattern;Peripheral;Phagocytosis;Phase;Physiological;Physiology;Platinum;Play;Pre-Clinical Model;preclinical study;Predisposition;Probiotics;Production;programmed cell death protein 1;Progression-Free Survivals;Prokaryotic Cells;Proteobacteria;Protocols documentation;Reactive Oxygen Species;reconstitution;reconstruction;Regulation;Reproducibility;Research Design;Resectable;Resistance;Resistance to infection;response;Role;Sample Size;Science;Services;Signal Transduction;Site;Skin;Statistical Models;stem;Structure;subcutaneous;Supporting Cell;symbiont;System;T-Lymphocyte;Technology;Therapeutic;Time;Tissues;TLR4 gene;treatment response;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health;user-friendly;Work

PROJECT_TITLE: Role of microbiome in cancer and inflammation


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

PI_NAMEs: YANG, LI  (contact)

PROJECT_TERMS: breast cancer metastasis;Breeding;Cancer Biology;Collaborations;Epithelial Cells;Fibroblasts;Genetic;Goals;Growth;Immune response;insight;Knockout Mice;Malignant - descriptor;Mediating;Modeling;Molecular;Mus;Myelogenous;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;Pathway interactions;Phenotype;promoter;receptor;Regulation;Research;Resources;Signal Pathway;Signal Transduction;targeted treatment;Transforming Growth Factor beta;translational potential;tumor;tumor progression;tumor-immune system interactions;Work

PROJECT_TITLE: Myeloid TGFbeta signaling in breast cancer metastasis


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

PROJECT_TERMS: cancer therapy;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Proliferation;Cell Survival;Cells;Chromatin;CRISPR/Cas technology;Epigenetic Process;Genetic;Genetic Transcription;genome-wide;growth promoting activity;histone modification;Hypermethylation;IL6 gene;Immune;immune checkpoint;immune checkpoint blockade;Immune response;immunoregulation;in vivo;Inflammatory;Inflammatory Response;JAK3 gene;loss of function;Malignant Neoplasms;Mediator;mouse model;Neoplasm Metastasis;neoplastic cell;NF1 gene;novel;Oncogenes;Pathway interactions;Patients;Play;pre-clinical;programmed cell death ligand 1;promoter;Regulation;Relapse;Reporting;Resistance;response;Role;screening;Signal Transduction;STAT3 gene;Tissues;Transforming Growth Factor beta;triple-negative invasive breast carcinoma;TSC1 gene;tumor;tumor microenvironment;Tumor Suppressor Proteins;tumor-immune system interactions

PROJECT_TITLE: Roles of tumor suppressors (TSs) in metastatic progression


NIH_SPENDING_CATS: Biotechnology;Cancer;Climate-Related Exposures and Conditions;Immunotherapy;Precision Medicine;Skin Cancer

PI_NAMEs: MERLINO, GLENN T. (contact)

PROJECT_TERMS: Adjuvant;Adjuvant Therapy;Affect;Animal Model;Anterior Pituitary Gland;anti-CTLA4;anti-PD-1;anti-PD-L1;Antibodies;Antineoplastic Agents;Award;Back;Bioinformatics;Biological Markers;Biological Models;Bioluminescence;bone;BRAF gene;Brain;C57BL/6 Mouse;Calendar;Carcinogens;Cause of Death;CCR;CDK4 gene;Cell Culture Techniques;Cell Line;Cells;Cephalic;Cessation of life;chemotherapy;Child;Clinic;Clinical;Clinical Trials;clinically relevant;Clonality;Collaborations;Combined Modality Therapy;COVID-19;CTLA4 gene;Cutaneous Melanoma;Data;Data Set;design;Development;dimethylbenzanthracene;Disease;Disease Progression;Distant;Drug Monitoring;Drug Targeting;effective therapy;efficacy study;Excision;Exclusion;Exhibits;experience;experimental study;Family suidae;Fluorescence;Functional disorder;Funding;fusion gene;Future;Gene Expression;Genetically Engineered Mouse;Goals;Growth;Head;Heterogeneity;Home;host neoplasm interaction;Human;Human Cell Line;human data;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune system;Immune System Diseases;immune system function;Immunocompetent;Immunocompromised Host;Immunotherapeutic agent;Immunotherapy;Impairment;Implant;improved;Inflammatory;inhibitor;insight;Intervention;ipilimumab;Label;Laboratories;Lentivirus;Link;Luciferases;Lung;Malignant Neoplasms;Manuscripts;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;Memorial Sloan-Kettering Cancer Center;Metastatic malignant neoplasm to brain;Metastatic Melanoma;Metastatic/Recurrent;Modeling;Monitor;mortality;mouse model;Mus;mutant;Mutation;Neoadjuvant Therapy;neoantigens;Neoplasm Metastasis;neoplastic cell;new therapeutic target;NF1 gene;Nivolumab;novel;novel strategies;objective response rate;Oncogenic;Operative Surgical Procedures;Optics;Organ;patient stratification;patient subsets;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Plumbing;posters;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical trial;predictive marker;Prevalence;prevent;Primary Neoplasm;Prior Therapy;Process;programmed cell death ligand 1;programmed cell death protein 1;programs;promoter;protein expression;Proteins;Rattus;Reagent;Recurrence;Recurrent disease;Reporter;Reporting;Resected;Resistance;resistance mechanism;Resources;response;Role;Running;Signal Transduction;Site;Somatotropin;Source;Study models;success;synergism;T-Lymphocyte;Technology;Testing;Therapeutic;therapeutic biomarker;Tissues;tool;Transgenic Mice;translational potential;tumor;tumor growth;tumor microenvironment;tumorigenic;Ultraviolet Rays;UV Radiation Exposure;Work

PROJECT_TITLE: Preclinical Mouse Models for Studying Immune Checkpoint Inhibitor Response


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Wound Healing and Care

PI_NAMEs: ZHANG, YING E (contact)

PROJECT_TERMS: Adult;Alleles;Cell Cycle Progression;Cell Physiology;clinically relevant;Collagen;Cutaneous;Data;Dedications;Development;DNA Damage;DNA Repair;embryonic stem cell;Enzymes;Epigenetic Process;Family;Fatty Acids;gastrulation;Genes;Genetic;Genetic Transcription;Genome Stability;Glucose Intolerance;high body mass index;histone modification;Homeostasis;Human;Inflammation;Inflammatory Response;Insulin Resistance;Investigation;Knockout Mice;Link;Lipids;Maintenance;Malignant Neoplasms;Mediating;member;Metabolic;Modeling;Modification;Mouse Embryonic Stem Cells;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Mutation;Nodal;non-alcoholic fatty liver disease;Obesity;Pathogenesis;Pathologic;Pathway interactions;Patients;Phosphorylation;Physiological;PPAR gamma;Predisposition;Proteasome Inhibitor;protein degradation;Proteins;Research;response;Role;Signal Induction;Signal Transduction;stem cell differentiation;success;Surgical incisions;System;Therapeutic Uses;Tissues;tool;Transforming Growth Factor beta;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;uptake;Weight Gain;wound;wound healing

PROJECT_TITLE: Physiological and pathological functions of E3 ubiquitin ligases Smurfs


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases

PI_NAMEs: ZIEGELBAUER, JOSEPH  (contact)

PROJECT_TERMS: Antigen Presentation;Biogenesis;Biological Assay;Cell Communication;Cell division;Cell Physiology;Cell surface;Cellular Immunity;circular RNA;Clinical;comparative;Coupled;Cytomegalovirus;Defect;Disease;DNA;Ectopic Expression;Endoribonucleases;Endosomes;Event;experimental study;Expression Profiling;gain of function;gammaherpesvirus;Gene Expression;Genes;Genetic Transcription;Goals;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;Human;Human Herpesvirus 4;Human Herpesvirus 8;Immune;in silico;Infection;interest;Interferon-beta;Interferons;Light;Location;loss of function;Lysine Degradation Pathway;Lytic;Lytic Phase;Malignant Neoplasms;Mediating;Messenger RNA;MicroRNAs;Molecular;mRNA Decay;Mus;new therapeutic target;Normal Cell;pathogen;Pathogenesis;Pathway interactions;Pattern;Play;Poly I-C;Poly(A) Tail;prevent;Publishing;Recombinant Interferon;Research;Resistance;Ribonucleases;RNA Decay;Role;senescence;Signal Transduction;TLR3 gene;TLR4 gene;Toll-like receptors;Transcript;transcriptome sequencing;Untranslated RNA;Up-Regulation;Viral;Viral Physiology;Virus Diseases;virus host interaction;Work

PROJECT_TITLE: Functions of KSHV microRNAs and circular RNAs


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetic Testing;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Women's Health Research

PI_NAMEs: SHARAN, SHYAM  (contact)

PROJECT_TERMS: Age;Bacterial Artificial Chromosomes;Biological Assay;BRCA1 gene;BRCA2 gene;breast cancer diagnosis;C-terminal;cancer diagnosis;Cancer-Predisposing Gene;Categories;Classification;Clinical;clinically significant;Codon Nucleotides;CRISPR/Cas technology;Development;Disease;DNA;DNA Binding Domain;DNA Repair Gene;ES Cell Line;Exons;Genes;Genetic;genetic information;genetic testing;genetic variant;genome editing;Germ-Line Mutation;Hereditary Breast Carcinoma;High Prevalence;high risk;Human;humanized mouse;Individual;Inherited;Malignant Breast Neoplasm;Malignant Neoplasms;Medicine;Mouse Embryonic Stem Cells;mutant;Mutation;Nature;Nucleotides;Pathogenicity;Persons;Population;repaired;Reporting;Risk;Risk Factors;Role;segregation;Sequence Analysis;Single Nucleotide Polymorphism;Testing;tumorigenesis;United States;Variant;variant of unknown significance;Woman

PROJECT_TITLE: Functional Analysis of Human Breast Cancer Susceptibility Gene Variants


NIH_SPENDING_CATS: Cancer;Rare Diseases

PI_NAMEs: ACHARYA, JAIRAJ  (contact)

PROJECT_TERMS: acquired drug resistance;adaptive immune response;Area;Autoimmune Diseases;Biological;Bone Marrow Stem Cell;c-myc Genes;Cell membrane;Cells;Cellular Structures;Ceramides;Colitis;Development;Enzymes;Experimental Autoimmune Encephalomyelitis;FRAP1 gene;Genes;Glucosylceramides;Glycolysis;Helper-Inducer T-Lymphocyte;Human;human disease;hypoxia inducible factor 1;Impairment;Inborn Errors of Metabolism;Lipids;Mammals;Membrane;Metabolic;Metabolism;mouse model;Multienzyme Complexes;Mus;NADP;Niemann-Pick Diseases;Oxidases;Pathway interactions;Play;Process;Proteins;Reactive Oxygen Species;Research;Research Personnel;Role;Second Messenger Systems;Serine;Shapes;Signal Transduction;Specific qualifier value;Sphingolipids;T-Lymphocyte;Transferase;tumor

PROJECT_TITLE: Sphingolipid Signaling in Mammals


NIH_SPENDING_CATS: Cancer;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

PI_NAMEs: WINK, DAVID  (contact)

PROJECT_TERMS: aerobic glycolysis;anti-cancer;Area;Award;Biological;Biology;blood pressure control;cancer prevention;cancer therapy;Chemicals;Disease;Endothelium;Goals;Heart;Heart failure;hypoxia inducible factor 1;Immune response;in vivo;Legal patent;Malignant Neoplasms;Metabolism;Methods;Modeling;Myocardial Infarction;neurotransmission;Nitric Oxide;Nitric Oxide Synthase;Nitrogen Oxides;Nitrosation;nitroxyl;Oxidation-Reduction;persulfides;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase III Clinical Trials;prevent;Production;Property;Regulation;Sulfhydryl Compounds;Therapeutic;Tissues;tumor;tumor growth;tumor metabolism

PROJECT_TITLE: Chemical Biology of Nitroxyl (HNO)


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: CHENG, SHEUE-YANN  (contact)

PROJECT_TERMS: Affect;anaplastic thyroid cancer;Attenuated;attenuation;Biological Assay;Biology;BRAF gene;cancer cell;cancer cell differentiation;Cancer cell line;Cancer Patient;cancer stem cell;Cell Proliferation;Cells;chemotherapy;Combined Modality Therapy;confocal imaging;Cultured Cells;Data;Databases;Development;Diagnosis;Disease;Endocrine Gland Neoplasms;Evaluation;Follicular thyroid carcinoma;Gene Expression;Genes;Genetic Transcription;Genomics;Growth and Development function;Human;Immunohistochemistry;improved;improved outcome;In Vitro;in vivo;Induction of Apoptosis;inhibitor;insight;kinase inhibitor;Malignant neoplasm of thyroid;Malignant Neoplasms;Mediating;MEK inhibition;MEKs;Messenger RNA;Molecular;Molecular Analysis;mouse model;Mutate;Mutation;neoplastic cell;novel;Operative Surgical Procedures;Papillary thyroid carcinoma;Patients;Pharmaceutical Preparations;Phase II Clinical Trials;pre-clinical;programs;Proteins;Proto-Oncogene Proteins B-raf;radioiodine therapy;Recurrence;Reporter;Resistance;RNA Polymerase II;Role;self-renewal;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Solid;stem cell biomarkers;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;THRA gene;Thyroid Gland;Thyroid Hormone Receptor;Thyroid hormone receptor alpha;Thyroid Hormones;transcription factor;transcriptomics;tumor;tumor growth;tumor xenograft;Tyrosine Kinase Inhibitor;United States Food and Drug Administration;Variant;Visualization;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Preclinical Mouse Models of Thyroid Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Lung;Lung Cancer;Neuroblastoma;Neurosciences;Ovarian Cancer;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases;Women's Health Research

PI_NAMEs: APPELLA, ETTORE  (contact)

PROJECT_TERMS: Ablation;Active Sites;Aspartic Acid;Binding;Binding Sites;Biochemical;Biological Assay;Biology;Biophysics;C-terminal;cancer cell;Catalysis;Catalytic Domain;Cell Proliferation;Cells;Characteristics;Chemistry;Chemotherapy-Oncologic Procedure;Clear cell carcinoma;Collaborations;Crossbreeding;Databases;Detection;Development;Dimethyl Sulfoxide;DNA Damage;Enterobacteria phage P1 Cre recombinase;Enzymes;experimental study;Family;Fluorescence;France;Genetic Transcription;Genomics;Goals;Growth;high throughput screening;Human;Hydrogen Bonding;Immune;Immune system;improved;inhibitor;insight;Investigation;Ionizing radiation;Ions;Journals;Kinetics;Lewis lung carcinoma cell;Libraries;LoxP-flanked allele;Magnesium;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;malignant stomach neoplasm;MAP Kinase Gene;Mass Spectrum Analysis;Medulloblastoma;Melanoma Tumor;member;Methods;Modeling;Molecular Conformation;molecular dynamics;Mus;Mutate;Myelogenous;National Center for Advancing Translational Sciences;neoplastic cell;Neuroblastoma;neutrophil;Neutrophil Infiltration;Nitrogen;Normal Cell;Outcome;Ovarian Clear Cell Tumor;overexpression;Oxygen;p38 Mitogen Activated Protein Kinase;Pancreatic Adenocarcinoma;phosphatase inhibitor;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Polyethylene Glycols;Positioning Attribute;PPM1D gene;promoter;Protein Isoforms;protein phosphatase 2C;Protein Serine/Threonine Phosphatase;Proteins;Publishing;Radiation therapy;Regulation;Research;Resistance;Resolution;Role;Running;screening;small molecule libraries;Stress;Structure;subcutaneous;Sulfur;Testing;TP53 gene;tumor;tumor growth;Tumor Immunity;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Ultraviolet Rays;Universities;virtual screening

PROJECT_TITLE: Regulation and Function of WIP1 Phosphatase and its Role in Tumor Cells


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: GOTTESMAN, SUSAN  (contact)

PROJECT_TERMS: Active Sites;Adaptor Signaling Protein;Affect;ATP phosphohydrolase;ATP-Dependent Proteases;ATPase Domain;Bacteria;Bacteria sigma factor KatF protein;Biochemical;Bioinformatics;Biological;biological adaptation to stress;C-terminal;Cell division;cell growth;Cells;Collaborations;Complex;Cues;Cytoplasm;Dissection;DNA Damage;DNA-Directed RNA Polymerase;endopeptidase Clp;Ensure;environmental change;Escherichia coli;Escherichia coli Proteins;Evolution;extreme temperature;falls;Family;Feedback;feeding;flexibility;Gammaproteobacteria;Gene Expression;Gene Expression Regulation;Gene Proteins;Genes;Genetic;Growth;Homeostasis;In Vitro;in vivo;inhibitor;inorganic phosphate;insight;interest;Magnesium;member;misfolded protein;Mitochondria;multicatalytic endopeptidase complex;mutant;Mutation Analysis;N-terminal;Names;novel;Organism;Peptide Hydrolases;Phosphoric Monoester Hydrolases;Play;Polymerase;Polysaccharides;Process;programs;promoter;Protease Domain;protein degradation;Protein Family;protein phosphatase 2C;Proteins;Proteolysis;Pseudomonas;Pseudomonas aeruginosa;Quality Control;reconstitution;Recovery;Regulation;Resistance;response;Role;Route;Shewanella;Sigma Factor;Signal Transduction;small molecule;Small RNA;Starvation;Stress;Structure;System;Testing;Translations;transmission process;Universities;Vibrio;Work

PROJECT_TITLE: Proteolysis and Regulation of Bacterial Cell Growth Control


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Breast Cancer;Cancer;Digestive Diseases;Lung;Lung Cancer;Orphan Drug;Pancreatic Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: STETLER-STEVENSON, WILLIAM  (contact)

PROJECT_TERMS: Acceleration;Angiogenesis Inhibitors;anti-cancer research;antitumor effect;Biochemical;Biological;Biological Assay;Biological Models;Biological Response Modifier Therapy;bioprocess;Breast;Breast Carcinoma;cancer therapy;cell growth;Cells;chemoradiation;Cloning;Codon Nucleotides;Collaborations;Complementary DNA;Development;Diagnosis;Disease Progression;Drug Delivery Systems;drug development;Elements;enteropeptidase;Enzyme Inhibition;Equilibrium;Extracellular Matrix;Formulation;Glioblastoma;Goals;Growth;Homeostasis;Human;human tissue;improved;In Vitro;in vitro testing;in vivo;in vivo Model;Infiltration;inhibitor;Laboratories;Luciferases;Lung;Lung Carcinoma;Lung Neoplasms;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Metalloproteases;method development;Methods;Mission;Modeling;mortality;mouse model;Mus;mutant;Mutation;Myeloid-derived suppressor cells;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;novel therapeutic intervention;novel therapeutics;Pancreas;Pancreatic carcinoma;Patients;Plasmids;Preparation;Primary Neoplasm;Production;Proteins;Protocols documentation;quality assurance;Recombinants;Reporting;Research;Site;Survival Rate;Techniques;Testing;Time;TIMP2 gene;Tissue Inhibitor of Metalloproteinases;Toxic effect;tumor;tumor growth;tumor microenvironment;tumor progression;tumor xenograft;tumorigenic;Wild Type Mouse

PROJECT_TITLE: Development of TIMP-2 derivatives or strategies as biologic therapies for cancer


NIH_SPENDING_CATS: Aging;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Rare Diseases

PI_NAMEs: DALAL, YAMINI P (contact)

PROJECT_TERMS: Address;Affect;aged;Aging;Back;Brain;cancer biomarkers;cancer cell;cancer initiation;cell age;Cell Aging;Cell Cycle Arrest;cell growth;Cell Separation;Cells;Centromere;centromere protein A;Chromatin;Chromatin Structure;Chromosomal Instability;Collaborations;Complex;Defect;differential expression;DNA;DNA Methylation;Down-Regulation;Epigenetic Process;Euchromatin;Failure;Fibroblasts;Genetic Transcription;genome-wide;Glioblastoma;Heterochromatin;Histone H3;Histones;Human;Individual;Journals;Kinetochores;knock-down;Link;Location;Malignant Neoplasms;Maps;Mediating;micronucleus;Mitotic;Molecular;new technology;Nuclear Accidents;Nucleoproteins;Organ;Organism;Organoids;Pathway interactions;Pattern;Peer Review;Predisposition;Process;Property;Proteins;Proteomics;Publishing;Research Personnel;Role;Skin;Solid;Specificity;Tissues;TP53 gene;tumor;Tumor Suppressor Proteins;tumorigenesis;Variant;Work

PROJECT_TITLE: Role of histone variants in aging and cancer


NIH_SPENDING_CATS: Aging;Bioengineering;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Rare Diseases

PROJECT_TERMS: 3-Dimensional;Address;Affect;Aging;aging related;Amino Acid Sequence;Atomic Force Microscopy;Biochemical;Biological Assay;Biology;Biomechanics;Biophysics;bioprinting;cancer cell;Cell Nucleus;Cells;Centromere;chemotherapy;Chromatin;Chromosomes;Complex;Country;Crowding;daughter cell;Disease;Elasticity;Endothelium;Epigenetic Process;epigenome;Eukaryota;field study;fighting;Genetic Transcription;Genome;Genomics;Glioblastoma;Goals;Growth;Histones;Immunofluorescence Immunologic;In Vitro;in vivo;Malignant - descriptor;Malignant Neoplasms;mechanical force;mechanical properties;Mechanics;member;Mitosis;Modeling;Normal Cell;novel therapeutics;Nuclear;Nucleosomes;Oncogenic;Outcome;Paper;Pathway interactions;Pharmaceutical Preparations;Phenotype;Polymers;Postdoctoral Fellow;Process;Property;Publishing;response;segregation;Seminal;sensor;Stains;Stress;Stretching;temozolomide;Therapeutic Agents;therapy development;Time;Tissues;tumor;tumor microenvironment;Variant;Work

PROJECT_TITLE: Biomechanical properties of chromatin in cancer and normal cells


PI_NAMEs: GREWAL, SHIVINDER S (contact)

PROJECT_TERMS: Acetylation;Amino Acids;Antineoplastic Agents;Binding;Binding Proteins;Biochemical;Biological Assay;Cancer Biology;cancer therapy;Cell Physiology;cell type;Centromere;centromere autoantigen 80K;centromere protein A;Chromatin;Chromatin Modeling;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Chromosome Segregation;Chromosome Structures;cohesin;cohesion;Complex;Coupled;Cullin Proteins;Defect;Development;DNA;DNA Binding;DNA biosynthesis;DNA Damage;Elements;Enzymes;Epigenetic Process;Euchromatin;Eukaryota;Eukaryotic Cell;Event;Family;Fission Yeast;Gene Expression Profile;Gene Expression Regulation;Gene Silencing;Genes;Genetic Screening;Genetic Transcription;Genome;genome integrity;Heterochromatin;Higher Order Chromatin Structure;Histone Deacetylase;Histone Deacetylase Inhibitor;Histone Deacetylation;Histone H3;histone methylation;histone methyltransferase;histone modification;Histones;Homologous Gene;Human;human disease;insight;Link;Lysine;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Methylation;methylation pattern;Modification;Molecular;Mutagens;mutant;novel;Nucleosomes;Pathway interactions;Pattern;Phosphorylation;Positioning Attribute;Post-Translational Protein Processing;posttranscriptional;prevent;Process;promoter;Proteins;recruit;Repression;Research;Retrotransposon;RNA Interference;RNA Polymerase I;RNA Polymerase II;Role;scaffold;Sister Chromatid;Site;Structure;Tail;therapeutically effective;Transcript;Transposase;ubiquitin ligase;Variant;Work

PROJECT_TITLE: Roles of Chromatin-modifying Factors in Epigenetic Control of the Genome


PROJECT_TERMS: Binding;Binding Proteins;Biological Models;Birth;Cell Cycle;Cells;Centromere;centromere protein A;Cessation of life;Chromatin;Chromosomes;Complex;Data;daughter cell;DNA;DNA Damage;DNA Repair;Epigenetic Process;Genome;Goals;Human;in vivo;International;Journals;Kinetochores;Life;Life Cycle Stages;Mechanics;Mitotic;nuclear division;Paper;Pathway interactions;Process;protein complex;Proteins;Publishing;restraint;segregation;Structure;tumorigenesis;Work

PROJECT_TITLE: Formation of Centromeres in vivo


PI_NAMEs: RAMAMURTHI, KUMARAN  (contact)

PROJECT_TERMS: Antibiotic Resistance;Antibiotics;Antigens;Applied Research;Area;Bacillus subtilis;Bacteria;Bacterial Spores;Basic Science;Breast Cancer Cell;cancer cell;Cell Communication;Cell Differentiation process;Cell division;Cell surface;Cells;Cellular Structures;chemical property;chemotherapeutic agent;Clinic;Clinical;Cytokinesis;Cytoplasm;Development;Disease;Doxorubicin;efficacy testing;Enzymes;ERBB2 gene;Event;Exhibits;Gene Deletion;Genes;Genetic Transcription;Heterogeneity;Immune response;immunogenicity;Infection;interest;Kinetics;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Melanoma;Membrane;Microbe;Modeling;Molecular;Molecular Chaperones;Morphogenesis;mouse model;Mus;Names;nanoenvironment;nanoparticle;neoantigens;Nosocomial Infections;novel;Organelles;particle;Pathway interactions;Peptide Vaccines;Peptides;Phenotype;physical property;Population;Process;Proteins;recruit;Reporting;Reproduction spores;resistant strain;Site;small molecule therapeutics;Staphylococcus aureus;Structure;Surface;synthetic construct;System;Technology;therapeutic RNA;Toxic effect;tumor growth;Vaccination;Virulence

PROJECT_TITLE: Subcellular protein localization in B. subtilis


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Skin Cancer

PI_NAMEs: HU, YINLING  (contact)

PROJECT_TERMS: Affect;Antibiotics;Bacteria;carcinogenesis;Carcinogens;Cells;Chemicals;Databases;Development;Disease;Environment;Epithelial Cells;Event;Genetic;Genomic Instability;Genomics;gut bacteria;Homeostasis;Human;IKK alpha;Immune system;Impairment;Inflammation;Investigation;Malignant Neoplasms;Microbe;microorganism;Molecular;Mus;Mutant Strains Mice;Mutation;neoplastic cell;Oncogenic;Organ;Pathway interactions;prevent;Reporting;Role;Skin;Skin Cancer;Skin Carcinogenesis;Skin Neoplasms;skin squamous cell carcinoma;Skin tumorigenesis;The Cancer Genome Atlas;Therapeutic;Time;tumor initiation;Tumor Suppressor Proteins;Ultraviolet B Radiation

PROJECT_TITLE: Functions of IKK alpha in Skin Homeostasis and Skin Tumorigenesis


PI_NAMEs: PARK, JUNG-HYUN  (contact)

PROJECT_TERMS: Affect;alpha-galactosylceramide;Alternative Splicing;Antibodies;Binding;Cell Physiology;Cell surface;Cell Survival;Cells;Characteristics;chromatin remodeling;conditional knockout;CRISPR/Cas technology;cytokine;Cytokine Receptors;Cytokine Signaling;Data;Development;Family;Generations;Genes;genomic locus;GFI1 gene;Homeostasis;IL17 gene;IL7 gene;Immunity;In Vitro;in vivo;Individual;Inflammatory;interest;Interleukin 2 Receptor Gamma;Interleukin 7 Receptor;Interleukin-15;Interleukin-2;interleukin-21;Interleukin-4;Interleukin-9;Intervention;Investigation;JAK1 gene;JAK3 gene;Knockout Mice;Life;Ligands;Ligation;Link;Maintenance;Mediating;member;Molecular;mouse model;Mus;Mutation;NF-kappa B;novel;nuclear factors of activated T-cells;Nucleic Acid Regulatory Sequences;overexpression;Peripheral;PIK3CG gene;Play;Population;Post-Transcriptional Regulation;Post-Translational Protein Processing;Process;Production;Promoter Regions;protein expression;Proteins;receptor;receptor expression;Receptor Signaling;Regulation;Regulatory Element;Regulatory Pathway;Reporting;Role;RUNX3 gene;Series;Signal Induction;Signal Pathway;Signal Transduction;Stat5 protein;Surface;Systems Analysis;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Thymus Gland;Tissues;TNF gene;tool;TRAMP protein;transcription factor;Transcriptional Regulation;Transgenic Mice;Zinc Fingers

PROJECT_TITLE: Post-Transcriptional Regulation of Interleukin-7 Receptor Expression


PROJECT_TERMS: Address;Adverse effects;Animal Model;Binding;CD8-Positive T-Lymphocytes;Cell Lineage;CISH gene;Complementary DNA;cytokine;Cytokine Receptors;Cytokine Signaling;Development;DNA cassette;effector T cell;Elements;embryonic stem cell;Engineering;Family;Feedback;Future;Gene Expression;Generations;Genes;Genetic Transcription;Homeostasis;Human;IL7 gene;Immune;immune activation;Immunology;In Vitro;in vivo;Inflammatory;Interleukin 2 Receptor Gamma;Interleukin 4 Receptor;Interleukin 7 Receptor;Interleukin-4;JAK1 gene;JAK3 gene;Janus kinase;LoxP-flanked allele;Malignant Neoplasms;Mediating;member;Monitor;mouse model;mRNA Expression;Mus;overexpression;Pathway interactions;Peptides;Phosphotransferases;Play;Process;protein degradation;Protein Tyrosine Kinase;receptor;Receptor Inhibition;Receptor Signaling;recruit;Regulation;Reporter;Reporter Genes;Reverse Transcriptase Polymerase Chain Reaction;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;single-cell RNA sequencing;Stretching;System;T cell differentiation;T memory cell;T-Cell Activation;T-Cell Development;T-Lymphocyte;thymocyte;Thymus Gland;TNFSF5 gene;tool;Transgenes;Transgenic Mice;Tyrosine Phosphorylation;ubiquitin ligase;ubiquitin-protein ligase

PROJECT_TITLE: Immune Regulatory Roles of Suppressor Of Cytokine Signaling (SOCS) Molecules


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Cerebrovascular;Neurodegenerative;Neurosciences;Radiation Oncology

PI_NAMEs: SMART, DEEDEE  (contact)

PROJECT_TERMS: Address;Affect;Animal Model;Astrocytes;Blood - brain barrier anatomy;Brain;Brain Injuries;brain parenchyma;brain tissue;Central Nervous System;Central Nervous System Diseases;Central Nervous System Neoplasms;cerebral microvasculature;clinical efficacy;Clinical Protocols;Cognition;Cranial Irradiation;Development;Disease;hearing impairment;Impaired cognition;improved;In Vitro;interest;Intervention;Ionizing radiation;long-term sequelae;Mediating;Memory impairment;Microglia;Molecular Target;neoplastic cell;Nerve Degeneration;Nervous System Trauma;Neurocognitive;Neurons;novel;Patients;preservation;Process;Radiation;Radiation Dose Unit;radiation mitigator;Radiation therapy;Regimen;side effect;Signal Transduction;Sirtuins;Specimen;Therapeutic;Toxic effect;Vascular Permeabilities

PROJECT_TITLE: CNS sirtuins in radiation-induced vascular permeability and neurodegeneration


NIH_SPENDING_CATS: Cancer;Chronic Pain;Interstitial Cystitis;Pain Research;Urologic Diseases

PI_NAMEs: BARCHI, JOSEPH JOHN (contact)

PROJECT_TERMS: Affect;anti-cancer;Antibodies;Binding;Biological;biophysical techniques;Bladder;Bladder Diseases;Data;design;Epithelial Cells;Epithelium;Glycobiology;Glycopeptides;Goals;Interstitial Cystitis;Lead;Link;Location;methyl group;Molecular Conformation;Morphology;Nature;neoplastic cell;novel;novel anticancer drug;Pain;Patients;Play;receptor;Resolution;Role;scaffold;Serine;sialylation;Threonine;Translating;Tumor Cell Line;Urine;Vaccines;Work

PROJECT_TITLE: A Glycopeptide from Interstitial Cystitis Patients as a Novel Anticancer Lead


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prevention;Women's Health Research

PI_NAMEs: HUNTER, KENT WILLIAM (contact)

PROJECT_TERMS: Adjuvant Chemotherapy;advanced breast cancer;American;Automobile Driving;Bioinformatics;Biology;breast cancer metastasis;burden of illness;Cancer Etiology;Cell Nucleus;Cell Physiology;Cellular Stress;Cessation of life;Clinical;Copy Number Polymorphism;Critical Pathways;Data;Data Set;design;Diagnosis;Discipline;Disease;Distant;driver mutation;epigenomics;Etiology;experience;Future;Gene Proteins;Genes;Genetic;Genetic Transcription;genome-wide;Genomic Instability;genomic locus;Genotype;Goals;Human Genetics;individual response;Inherited;Intervention;Investigation;Localized Disease;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Meiosis;member;Messenger RNA;metastatic process;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;mouse genetics;Mouse Mammary Tumor Virus;mouse model;multidisciplinary;Mutation;Neoplasm Metastasis;neoplastic cell;Nuclear;Ontology;Patients;Penetrance;Point Mutation;polyoma middle tumor antigen;precision medicine;Predisposition;prevent;Primary Lesion;Primary Neoplasm;Proteins;Proteomics;Public Health;Recurrence;Relapse;response;RNA;RNA Splicing;Single Nucleotide Polymorphism;Somatic Mutation;Spliceosomes;Survival Rate;Susceptibility Gene;System;Therapeutic;transcriptome sequencing;tumor progression;United States;Variant;Woman

PROJECT_TITLE: Genetic Modifiers of Initiation and Progression of Mammary Cancer


PI_NAMEs: ASHWELL, JONATHAN  (contact)

PROJECT_TERMS: Ablation;acute T-cell lymphoblastic leukemia cell;Apoptosis;Apoptotic;Biological Process;Cancer cell line;cancer therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;Cell Nucleus;Cell Physiology;Cell Survival;Cells;Cessation of life;Clinical;Clinical Research;CRISPR screen;cytokine;cytotoxic;Data;Deoxycorticosterone;Dexamethasone;Enzymes;Epithelium;Frequencies;Genes;Genetic;Genetic Transcription;Glucocorticoid Receptor;Glucocorticoid-induced apoptosis;Glucocorticoids;Goals;Growth;Half-Life;Hematopoietic;Hematopoietic Neoplasms;histone methyltransferase;Human;Immunosuppressive Agents;Immunotherapy;In Vitro;in vivo;Individual;Infiltration;Investigation;Jurkat Cells;knockout gene;Laboratories;Lymphocyte;Malignant - descriptor;Malignant lymphoid neoplasm;Mature T-Lymphocyte;Mediating;Mus;Mutate;Mutation;Names;overexpression;Parents;PD-1 blockade;pharmacologic;Predisposition;prevent;Process;Regenerative pathway;Regulatory T-Lymphocyte;Reporting;Resistance;T-Cell Activation;T-Cell Development;T-Lymphocyte;Thymus Gland;tumor;tumor growth;tumor progression;Tumor-Derived;Tumor-Infiltrating Lymphocytes;Ubiquitination;Work

PROJECT_TITLE: Glucocorticoids and T cell development and function


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Eye Disease and Disorders of Vision;Immunotherapy;Liver Disease;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

PI_NAMEs: RUDLOFF, UDO  (contact)

PROJECT_TERMS: Achievement;Address;Amino Acids;analog;Antitumor Response;Binding;Biological;Biological Availability;Blindness;cancer cell;cancer classification;cancer immunotherapy;Cancer Model;Cancer Patient;Canis familiaris;Cell Death Induction;cell killing;Cell Nucleolus;Cell Nucleus;Cells;checkpoint inhibition;Clinical;clinical candidate;clinical translation;Complex;CTLA4 blockade;Data;Dedications;design;Development;Diabetic Retinopathy;Diffuse;Disease;Disseminated Malignant Neoplasm;Dose;drug candidate;Drug Combinations;Drug Design;drug development;drug discovery;Drug Kinetics;effective therapy;efficacy study;Environment;exosome;Eye diseases;Fibrosis;first-in-human;Future;Genome;glycosylation;Goals;Hemorrhage;Human;Immune;immune activation;immune checkpoint;Immune Targeting;Immunologics;Immunooncology;improved;in silico;Inflammatory;inhibitor;innate immune checkpoint;innovation;Interferon Type I;Intramural Research Program;Investigational Therapies;Laboratories;Lesion;Ligation;Liver Fibrosis;Macrophage;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;mannose receptor;manufacture;Maximum Tolerated Dose;Measurement;Measures;Mediating;Medical;Modeling;Modification;molecular marker;Mus;Myeloid Cells;nanobodies;National Center for Advancing Translational Sciences;Neoplasm Metastasis;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Non-Malignant;novel;novel anticancer drug;Oral;Organ;Pancreas;particle;Patient Selection;Patients;PD-1/PD-L1;PD-L1 blockade;Peptides;Phagocytosis;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;phase 1 study;phase 1 testing;phase I trial;Phenotype;Physical condensation;Polymerase;Population;pre-clinical;Pre-Clinical Model;preclinical development;Preclinical Drug Development;preclinical efficacy;preclinical safety;preclinical toxicity;predictive marker;Prevalence;Process;programs;proliferative diabetic retinopathy;Protein Isoforms;Pyrazines;receptor;recruit;Regimen;Reporting;Research;research clinical testing;resistance mechanism;response;Ribonucleoproteins;Ribosomal RNA;Ribosomes;Safety;safety study;Sarcoma;Schedule;screening;Sentinel;Serum;sialylation;Signal Transduction;small molecule;small molecule inhibitor;small molecule libraries;Solid;Solid Neoplasm;T-Cell Activation;Tablets;Therapeutic;therapeutic development;therapy development;Toxic effect;Toxicokinetics;TP53 gene;Translating;tumor;Tumor-associated macrophages;Work

PROJECT_TITLE: Preclinical drug development in pancreatic cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Orphan Drug;Radiation Oncology;Rare Diseases

PI_NAMEs: NILUBOL, NARIS  (contact)

PROJECT_TERMS: 3-Dimensional;Adherent Culture;Adrenal Cortex Hormones;Adrenocortical Carcinoma;Agreement;anaplastic thyroid cancer;Apoptosis;Auranofin;Autophagocytosis;biological adaptation to stress;Biological Assay;BRCA1 gene;cancer care;Cancer Patient;Candidate Disease Gene;candidate selection;candidate validation;CASP3 gene;Caspase;CCNB1 gene;CDC2 gene;Cell Cycle Arrest;Cell Death;Cell Line;Cell Proliferation;Cells;CHEK1 gene;Client;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Combined Modality Therapy;computerized;CTNNB1 gene;Custom;cytotoxic;Data;Databases;Development;differential expression;Disease-Free Survival;DNA Double Strand Break;Dose;Down-Regulation;Drug Combinations;Drug Delivery Systems;efficacy validation;Enzymes;Epithelium;Exclusion;Family;Fibroblasts;Fractionated radiotherapy;FRAP1 gene;Genes;Goals;Heat-Shock Proteins 90;High Pressure Liquid Chromatography;high-throughput drug screening;Hyaluronan;Hydrocortisone;improved;In Vitro;in vivo;Induction of Apoptosis;inhibitor;interstitial;Invaded;Iodine;Label;Libraries;Lipid Peroxidation;LOX gene;malignant endocrine gland neoplasm;Malignant neoplasm of thyroid;Malignant Neoplasms;Manuscripts;Mesenchymal;Messenger RNA;Migration Assay;Mitotic;Molecular;molecular targeted therapies;mRNA Expression;multiple omics;Mus;Mutation;nanoGold;novel;novel anticancer drug;Nuclear Translocation;Operative Surgical Procedures;Organoids;overexpression;Oxidative Stress;Paclitaxel;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;phosphoproteomics;PIK3CG gene;Play;Preparation;pressure;Prognostic Marker;Protein Isoforms;Proto-Oncogene Proteins c-akt;public database;Quality of life;radiation resistance;Radiation therapy;Radiation Tolerance;Radiation-Sensitizing Agents;Recombinants;Recurrence;repaired;Resistance;Role;Sampling;Scheme;Science;screening;Signal Transduction;SMARCA4 gene;spheroids;Strategic Planning;Survivors;synergism;therapeutic target;thioredoxin reductase;TNF gene;transcriptome sequencing;Transforming Growth Factor beta;treatment effect;Treatment Efficacy;treatment group;tumor;Tumor Burden;Validation;Vascular Endothelial Growth Factors;Vascular Permeabilities;Work;Xenograft procedure

PROJECT_TITLE: Therapeutic targets and novel anticancer agents for endocrine cancers


PI_NAMEs: OBERDOERFFER, SHALINI  (contact)

PROJECT_TERMS: 5' Untranslated Regions;Ablation;Acetylation;Acetyltransferase;Address;Behavior;Binding;Biology;cancer cell;Carbon;Cell Cycle;Cell division;Cell Line;Cell Physiology;Cell Proliferation;Cells;Chemicals;Code;cohort;CpG dinucleotide;Cytidine;Cytosine;Development;Disease;DNA;DNA Methylation;DNA-Binding Proteins;Enzymes;Epigenetic Process;epigenome;epitranscriptome;Etiology;Event;Exclusion;Exons;Future;Gene Expression;Genes;Genetic Code;Genetic Transcription;Human;Kinetics;Laboratories;Life;Life Cycle Stages;Location;Malignant Neoplasms;Mammals;Maps;Medicine;Messenger RNA;Methylation;methylome;Modification;Molecular;Mutation;Nature;next generation;novel;novel therapeutic intervention;Nucleic Acids;nucleobase;Nucleotides;Outcome;oxidation;Physiological;Post-Translational Regulation;Protein translocation;Proteins;Proteome;Regulation;Reporter;Research;RNA;RNA metabolism;RNA Polymerase II;RNA Processing;RNA Splicing;RNA, Messenger, Splicing;Role;Shapes;Site;Spliceosome Assembly Pathway;Technology;tool;Transcript;Transcription Initiation;transcriptome;Translation Initiation;Translation Process;Translational Repression;Translations;Variant

PROJECT_TITLE: Cytidine modifications in mRNA processing and function


PI_NAMEs: LUO, JI  (contact)

PROJECT_TERMS: Antineoplastic Agents;Autophagocytosis;biological adaptation to stress;Biological Models;Cancer Biology;cancer cell;cancer genome;cancer therapy;Categories;Cells;CHD1 gene;Chromosomal Stability;combinatorial;Dependence;Development;DNA Damage;Drug Targeting;effective therapy;Equilibrium;Evolution;experience;Genes;Genetic;Genetic Screening;Goals;Growth;Immunologic Surveillance;In Vitro;in vivo;Inflammatory;inhibitor;Knowledge;KRAS oncogenesis;KRAS2 gene;Ligase;Malignant Neoplasms;malignant state;Mass Spectrum Analysis;Metabolic stress;Mitotic;Molecular;mutant;Mutate;Neoplasm Metastasis;Normal Cell;novel therapeutics;oncogene addiction;Oncogenes;Oncogenic;Pathway interactions;pharmacologic;Phenotype;Play;Pre-Clinical Model;Proteins;proteotoxicity;Publishing;RAF1 gene;RNA Interference;RNA interference screen;RNA Splicing;Role;Signal Transduction;small molecule;Spliceosomes;Stress;Sumoylation Pathway;targeted treatment;Therapeutic;tumor;Work

PROJECT_TITLE: Non-oncogene addiction in cancer cells


PROJECT_TERMS: Acceleration;anti-cancer research;cancer cell;cancer genome;Cancer Model;cell behavior;Cells;Collection;combinatorial;Complex;CRISPR library;CRISPR/Cas technology;Dependence;flexibility;gene editing technology;Gene Expression;Gene Mutation;Genes;Genetic;genetic analysis;genetic manipulation;Genetic Screening;genetic testing;genome editing;genome-wide;genomic locus;Genotype;Guide RNA;Human;knock-down;knockout gene;Libraries;Mammalian Cell;Mammalian Genetics;Methods;Modeling;Mus;Mutation;neoplastic cell;paralogous gene;Pattern;preclinical study;Proteins;Publishing;Reagent;RNA Interference;Small Interfering RNA;Somatic Mutation;Technology;tool;tumor;Work

PROJECT_TITLE: Methods for mammalian genetic analysis


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: TARASOVA, NADYA  (contact)

PROJECT_TERMS: Biological Models;CCR;Chemicals;Collaborations;Databases;Development;dimer;Disease;Docking;drug discovery;Drug Targeting;drug-like compound;Equipment and supply inventories;Exclusion;Freedom;Goals;high throughput screening;improved;Industrialization;inhibitor;Knowledge;KRAS2 gene;Libraries;Methodology;Methods;Molecular Weight;mutant;novel;novel strategies;Pathway interactions;Process;programmed cell death ligand 1;protein protein interaction;Proteins;Research;screening;Speed;Ukraine;virtual;virtual library;virtual screening

PROJECT_TITLE: Inhibitors of protein-protein interactions


NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Women's Health Research

PI_NAMEs: SHARAN, SHYAM  (contact)

PROJECT_TERMS: Affect;Alleles;Allografting;Apoptosis;Biological;Biological Assay;BRCA deficient;BRCA1 gene;BRCA2 gene;BRCA2 Mutation;Breast;Cell Cycle Arrest;Cell Cycle Checkpoint;Cell Death;Cell division;Cell Line;Cell Survival;cell type;Cells;Chromosome abnormality;Clone Cells;coping;CRISPR/Cas technology;Cytogenetics;Cytoprotection;Data Set;Defect;Development;DNA;DNA Damage;DNA Repair;DNA replication fork;Double Strand Break Repair;Embryo;embryonic stem cell;Epithelium;ESR1 gene;Essential Genes;Estrogen receptor positive;Estrogen Therapy;Estrogens;Fibroblasts;Flap Endonucleases;G2 Phase;Genes;Genetic;Genetic Screening;Genome;Genomic Instability;Germ-Line Mutation;Goals;Growth;homologous recombination;homologous recombination deficiency;Human Cell Line;Immunoprecipitation;in silico;In Vitro;Individual;Knockout Mice;Laboratories;Lower Organism;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Mammary Neoplasms;Mediating;MLH1 gene;Modeling;Mouse Cell Line;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;mutation carrier;Neoplasms;neoplastic cell;new therapeutic target;nuclease;Okazaki fragments;Organoids;Ovarian;overexpression;Pathway interactions;Patient-Focused Outcomes;Phenotype;Physiological;potential biomarker;predictive marker;Process;Proliferating;Promoter Regions;repaired;Resolution;response;Response Elements;restoration;RNA;RNA primers;RNA Processing;Role;S phase;Sequence Analysis;Somatic Cell;Speed;Stress;Structure;Supporting Cell;System;Tamoxifen;The Cancer Genome Atlas;Tissues;TP53 gene;transcriptome sequencing;tumor;tumor growth;tumorigenesis;Variant;Visualization;whole genome

PROJECT_TITLE: Identification of genetic interactors of Brca2


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PI_NAMEs: SCHNEIDER, JOEL  (contact)

PROJECT_TERMS: beta pleated sheet;Biocompatible Materials;biological systems;Buffers;Cells;Characteristics;Charge;Chemical Structure;Chemicals;clinical application;covalent bond;crosslink;design;Diffusion;Electrostatics;Encapsulated;Event;experimental study;Face;Family;Future;Gel;Goals;Hydrogels;Hydrogen Bonding;hydrophilicity;Hydrophobicity;Implant;Ionic Strengths;Knowledge;Light;mechanical behavior;Mechanics;Metal Ion Binding;Methods;Microscopy;Molecular;monomer;Morphology;nanoparticle;Nature;novel;Nucleic Acids;peptide structure;Peptides;Pharmaceutical Preparations;Property;Proteins;Protocols documentation;Publishing;Recovery;response;Sampling;self assembly;small molecule;solid state nuclear magnetic resonance;Solvents;stoichiometry;Structure;Surface;Syringes;System;Temperature;Thinness;Time;Tissues;Water

PROJECT_TITLE: Design and Utility of Novel Proteinaceous Biomaterials


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Adhesions;Adsorption;amphiphilicity;Anti-Bacterial Agents;Antibiotics;aqueous;Binding;Binding Sites;Buffers;cancer cell;Cell membrane;Cell surface;cell type;Cell Wall;Cell-Matrix Junction;Cells;Characteristics;Charge;Chemicals;Chemistry;clinical translation;Coupled;cycloaddition;design;Development;Drug Delivery Systems;Drug Targeting;Electrostatics;Engineering;Environment;Event;Gel;Hemolysis;human induced pluripotent stem cells;Hydrophobic Surfaces;Hydrophobicity;implant material;Injections;Ligation;Lytic;Maintenance;Membrane;Methods;Molecular Conformation;nanocolloid;novel therapeutics;Pathogenesis;Penetration;Peptides;Periodicity;Pharmaceutical Preparations;Phenotype;Polysaccharides;Polystyrenes;Process;protein aminoacid sequence;Quantum Dots;response;self assembly;Sialic Acids;Site;small molecule;Surface;surface coating;Therapeutic;tool;Vitronectin;Wettability

PROJECT_TITLE: Development of antibacterial agents and materials


PI_NAMEs: LEWANDOSKI, MARK B (contact)

PROJECT_TERMS: Address;angiogenesis;Behavior Control;bone;Cardiac;cell behavior;Cell Communication;Cell Death;Cells;Chromium;Chronic Kidney Failure;Cis-Acting Sequence;Defect;Disease;Embryo;embryo cell;Embryonic Development;FGFR1 gene;FGFR2 gene;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Freezing;Gene Expression;Gene Targeting;Genes;Genomics;Genotype;Goals;Growth Factor Gene;innovation;Malignant Neoplasms;Mesoderm;migration;Mus;mutant;neurogenesis;new technology;Pathology;Play;Proliferating;Publications;RNA;RNA Sequences;Role;Signal Pathway;Signal Transduction;Trans-Activators

PROJECT_TITLE: Identification and characterization of FGF target genes


PI_NAMEs: REIN, ALAN  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Atomic Force Microscopy;base;Biology;Biophysics;CCR;Cell Nucleus;Cells;Collaborations;Computing Methodologies;design;Dimensions;dimer;Ebola virus;Elements;Embryo;Endogenous Retroviruses;Equine Infectious Anemia Virus;flexibility;HIV-1;Human;Image;interest;Laboratories;Leg;Methodology;Molecular;Molecular Conformation;Murine leukemia virus;Mus;Nature;Nucleic Acids;Population;Property;Proteins;Reagent;Reporting;Resolution;Response Elements;Retroelements;Retroviridae;rev Protein;RNA;RNA Splicing;Roentgen Rays;Role;Shapes;Sorting;structural biology;Structural Models;Structure;Structure-Activity Relationship;Techniques;three dimensional structure;tool;Viral;Viral Proteins;viral RNA;Virus

PROJECT_TITLE: Retrovirus Biology


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: MELTZER, PAUL S. (contact)

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Adolescent;Adult;Affect;Age;Bioinformatics;Biological Markers;Biology;Bone neoplasms;Breeding;cancer genome;canine model;Canis familiaris;CCR;Cell Cycle;Cells;chemotherapy;Child;chromothripsis;Classification;Clinical;clinical candidate;Clinical Research;clinically relevant;Clonal Evolution;Clonality;Collaborations;comparative genomics;Complex;Data;Data Set;Deposition;Development;Diagnosis;Disease;DNA Methylation;dog genome;Epigenetic Process;Event;Exclusion;extrachromosomal DNA;Frequencies;Future;gain of function;Gene Dosage;Genes;Genetic;Genome;genomic biomarker;genomic data;Genomic Instability;Geography;Goals;Growth;Histology;Human;human disease;Immunotherapy;Individual;Inflammatory;insight;interest;Knowledge;Laboratories;limb amputation;Malignant - descriptor;Malignant Bone Neoplasm;malignant phenotype;Maps;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Multiomic Data;Mutation;Neoadjuvant Therapy;Neoplasm Metastasis;next generation sequencing;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Oncologist;oncology program;Operative Surgical Procedures;Osteosarcoma;Outcome;Pathway interactions;Patients;Pattern;Pediatric Oncology Group;Postoperative Period;pre-clinical research;Precision therapeutics;pressure;Primary Neoplasm;Prior Chemotherapy;Property;public database;Recurrence;Recurrent disease;Reporting;Resistance;Resources;response;RNA methylation;Role;Sampling;Shapes;Signal Transduction;single cell analysis;Surgical Management;System;targeted treatment;Therapeutic;Time;TP53 gene;transcriptome;Transduction Gene;Translational Research;tumor;tumor initiation;tumor-immune system interactions;Work

PROJECT_TITLE: Characterization of the Osteosarcoma Genome


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Hematology;Immunotherapy;Liver Disease;Lung;Lung Cancer;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

PI_NAMEs: KAPLAN, ROSANDRA  (contact)

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Adhesions;Adjuvant;adolescent patient;Adrenocortical Carcinoma;Adult;angiogenesis;anti-cancer research;Area;Biological Markers;Blood Vessels;Bone Marrow;Breast Carcinoma;cancer cell;cancer therapy;cancer type;Cell Communication;Cell Compartmentation;Cell Survival;Cell Therapy;Cells;Cellular Assay;cellular engineering;Cessation of life;Characteristics;Childhood;Childhood Lymphoma;Circulation;Clinical;Clinical Protocols;Clinical Research;clinical translation;Colon Carcinoma;CSF1R gene;Cyclophosphamide;cytokine;Data;Deposition;design;Disease;Distant;Dose;Dysmyelopoietic Syndromes;efficacy evaluation;Endothelial Cells;Engineering;Environment;Event;Ewings sarcoma;Extracellular Matrix;Fibroblasts;first-in-human;FLT3 gene;fludarabine;Gene Expression;Genes;Genetic Engineering;genetic manipulation;Genomics;Giant Cell Tumors;Glioma;Goals;Growth;Hematopoietic;Hematopoietic Stem Cell Mobilization;hematopoietic stem cell niche;Hematopoietic stem cells;Human;human tissue;Immune;immune checkpoint blockade;Immune Evasion;Immunosuppression;Individual;Infiltration;insight;Interleukin-12;Investigation;Lead;Liver;Lung;Lung Carcinoma;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of adrenal cortex;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant Neoplasms;manufacture;Mediating;Melanoma;Mesenchymal;Metastatic Neoplasm to the Liver;Metastatic Neoplasm to the Lung;metastatic process;Modeling;Modification;Molecular;monocyte;mouse model;Mus;Mutation;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Nature;Neoplasm Metastasis;neoplastic cell;Neuroblastoma;neurofibroma;novel;novel strategies;Osteosarcoma;Patients;Pediatric Neoplasm;pediatric patients;Pericytes;Pharmaceutical Preparations;Phase;phase I trial;Physiological;Play;Population;pre-clinical;Pre-Clinical Model;preclinical efficacy;preclinical study;prevent;Primary Neoplasm;Process;Program Research Project Grants;programs;Proliferating;Proteins;recruit;Recurrence;Refractory;Regulation;Reproducibility;response;Rhabdomyosarcoma;Role;Running;Sampling;Sarcoma;single cell analysis;Site;small molecule inhibitor;Soil;stem cell niche;Stromal Cells;Structure of parenchyma of lung;T cell response;T cell therapy;Therapeutic;therapeutic target;therapy design;therapy development;Tissues;Translating;translational study;trial planning;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;tumor-immune system interactions;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: Tumor Microenvironment in Cancer Progression