NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Immunization;Immunotherapy;Muscular Dystrophy;Pediatric;Prevention;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Duchenne muscular dystrophy is a deadly genetic disease that can potentially be treated with gene therapy. The goal of this project is overcome serious obstacles posed by immune response to gene therapy so that long-term treatment in patients can be accomplished.

PI_NAMEs: DUAN, DONGSHENG ;HERZOG, ROLAND W. (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;adeno-associated viral vector;alpha 1-Antitrypsin;Animal Model;Antibodies;Antibody Formation;Antigen-Presenting Cells;Antigens;B-Lymphocytes;base editor;Canis familiaris;Capsid;CD8-Positive T-Lymphocytes;Cell Survival;Clinical;Complement Activation;Complex;cross reactivity;Cytoplasm;Cytotoxic T-Lymphocytes;Degenerative Disorder;delivery vehicle;Disease;DNA;Dose;Double-Stranded RNA;Duchenne muscular dystrophy;Dystrophin;Endosomes;Engineering;Factor IX;gene complementation;Gene Delivery;gene product;gene therapy;Gene Transfer;Genes;Genetic;Genetic Diseases;Glycogen storage disease type II;Goals;HIV;Human;IL1R1 gene;Immune;Immune response;Immunity;Immunization;Immunoglobulins;immunotoxicity;in vivo;Inflammation;innate immune sensing;insight;Interferons;Interleukin-1;Interleukin-1 alpha;Interleukin-4;Intervention;Intramuscular;Intramuscular Injections;Laboratories;Link;lipoprotein lipase;Liver;Mediating;Medical;Memory;micro-dystrophin;MicroRNAs;Modeling;Molecular;Muscle;muscle degeneration;Muscular Dystrophies;neutralizing antibody;novel;novel strategies;nuclease;Ovalbumin;passive antibodies;Passive Immunization;pathogenic virus;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;preclinical study;preservation;prevent;Prevention;Protocols documentation;Reagent;response;Risk Reduction;Role;Route;Safety;Serotyping;Signal Pathway;Signal Transduction;Skeletal Muscle;Source;T cell response;TBK1 gene;therapeutic protein;therapeutic transgene;therapy duration;Time;TLR3 gene;Toxic effect;Transgenes;Translational Research;vector;vector genome;Viral;Viral Genes;Viral Vector

PROJECT_TITLE: Mechanism of immune response to muscle-directed AAV gene transfer

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Substance Misuse

ORG_CITY: LOUISVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PI_NAMEs: GHARE, SMITA S (contact)

PROJECT_TERMS: Acetylation;Affect;alcohol effect;alcohol exposure;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Attenuated;beta-Chemokines;Binding;Biological Models;Biopsy;Butyrates;Centers of Research Excellence;chemokine;chromatin remodeling;Chronic;Clinical;cohort;CXC Chemokines;CXCL2 gene;cytokine;Cytokine Activation;Data;Deacetylation;Development;dietary;DNA Binding;Doctor of Philosophy;Epigenetic Process;Ethanol;Fatty acid glycerol esters;FDA approved;Genes;Genetic Transcription;Goals;HDAC3 gene;Hepatic;Hepatocyte;Histone Acetylation;histone acetyltransferase;Histone Deacetylase;Histone Deacetylase Inhibitor;Histone H3;histone modification;Histones;IL8 gene;in vitro Model;in vivo;Inflammation;Inflammatory;Injury;insight;Intervention;Knockout Mice;Ligands;Liver diseases;liver inflammation;liver injury;Macrophage Activation;Mediating;Modification;Molecular;Morbidity - disease rate;mortality;Mus;Myeloid Cells;Neutrophil Infiltration;non-histone protein;nucleocytoplasmic transport;nutrition;Organ;Oxidative Stress;p65;Pathogenicity;Pathology;Patients;Plasma;Play;Post-Translational Protein Processing;prevent;Preventive;Prodrugs;promoter;recruit;Regulation;response;Role;Serum;Severity of illness;Stimulus;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Toxicology;Transactivation;transcription factor;Transcriptional Activation;translational study;tributyrin;Up-Regulation;Work

PROJECT_TITLE: Project 4 - Smita Ghare, PhD


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Biomedical Imaging;Chronic Pain;Clinical Research;Pain Research;Physical Activity

ORG_CITY: CHICAGO

ORG_DEPT: ORTHOPEDICS

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Narrative  The intervertebral discs of the lumbar spine naturally degenerate with age and are implicated in low back pain, the world’s leading cause of disability. Exercise has the potential to reverse disc degeneration by increasing the transport of important nutrients into the disc. The overall goal of this proposal is to develop and implement exercise strategies to improve disc health.

PI_NAMEs: MARTIN, JOHN  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Adult;Affect;Age;age related;aged;Anabolism;Anatomy;Animal Model;Animals;Back Pain;Benchmarking;Biological Assay;Blood Vessels;Cartilage;Cell membrane;Cell Survival;Cells;Cellular biology;Characteristics;Clinical;clinical implementation;Control Groups;Convection;Devices;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;disability;disc regeneration;Dose;Elderly;Excision;Exercise;exercise intensity;exercise program;experience;fluorodeoxyglucose;Frequencies;Future;Geometry;Glucose;Glucose Transporter;glucose uptake;GLUT-1 protein;Goals;grasp;Health;Homeostasis;Human;Image;imaging modality;improved;in vivo;instrument;Intervertebral disc structure;intervertebral disk degeneration;Liquid substance;Literature;Low Back Pain;Magnetic Resonance Imaging;Maps;Measures;Membrane Transport Proteins;Modeling;non-invasive imaging;Nutrient;Operative Surgical Procedures;Oxygen;Pain;pain outcome;pain sensitivity;Patients;Peripheral;peripheral pain;PET/CT scan;Porosity;Process;programs;protein expression;Protocols documentation;radiological imaging;radiotracer;Rattus;Recovery;regenerative;response;Running;sample fixation;solute;Speed;Spinal Diseases;spine bone structure;Structure;System;Testing;Training;Translating;translational pipeline;Translations;treadmill;Vertebral column;wasting;Work

PROJECT_TITLE: Exercise-Induced Recovery of Intervertebral Disc Health

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Disability Research;Patient Safety;Prevention;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE. Radiation-induced fibrosis (RIF) is a common treatment-related sequela experienced by head and neck cancer survivors and is associated with co-occurring adverse treatment effects. However, an understanding of the phenotypes and predictors of RIF and subsequent adverse effects (i.e., neck disability, dysphagia) is lacking, prohibiting the development of tailored interventions to improve patient survivorship.

PI_NAMEs: NILSEN, MARCI LEE  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Acute;acute toxicity;Adverse effects;aggressive therapy;Alcohol consumption;Aspiration Pneumonia;Biological Factors;Biological Markers;Cancer Survivor;cancer therapy;Characteristics;chemoradiation;circulating microRNA;Clinical;Common Terminology Criteria for Adverse Events;common treatment;cost;Data;Deglutition;Deglutition Disorders;Development;differential expression;disability;Disability scale;Distress;Elastic Tissue;experience;Fibrosis;follow-up;Goals;Head and Neck Cancer;head and neck cancer patient;Health;Image;Impairment;improved;Incidence;Individual;Inflammation;insight;Intervention;Life;Link;Logistic Regressions;longitudinal design;Malignant Neoplasms;Malnutrition;Medical Records;MicroRNAs;Modeling;Morbidity - disease rate;mortality;National Cancer Institute;Neck;nonhuman primate;Outcome;Pain;Participant;Patients;Pattern;Perception;Personal Satisfaction;Phenotype;Plague;Play;potential biomarker;prognosis biomarker;Prospective Studies;Quality of life;Radiation;Radiation Fibrosis;radiation mitigation;radiation risk;Regimen;Reporting;Research;Role;Severities;Site;standard care;Survivors;survivorship;Symptoms;therapy adverse effect;Time;Tissues;Toxic effect;transcriptome sequencing;treatment effect;Treatment Factor;treatment response;Validation;Variant;Whole Blood;Work

PROJECT_TITLE: Radiation-Induced Fibrosis and Co-occurring Adverse Treatment-Related Effects in Head and Neck Cancer Survivors

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MATHER

ORG_NAME: VA NORTHERN CALIFORNIA HEALTH CARE SYS

ORG_STATE: CA

PHR: Squamous cell carcinomas (SCCs) arise from stratified epithelia, the most relevant organ sites in the veteran population are the skin and oral cavity. SCC’s worst outcome is to break indolence and cause death through metastasis, most commonly in the lung. SCC deaths actually exceed melanoma deaths due to the high number of SCC cases. In veterans, elevated exposure to UV irradiation and tobacco carcinogens make the total and high-risk SCCs significantly higher than the civilian population. The dearth of spontaneous SCC lung metastasis models has hindered identification of their therapeutic targets. We have developed a genetic mouse model with spontaneous SCC lung metastasis that can be transplanted to immune competent or compromised mice. These models are unique tools for cross-species comparison with patient’s metastatic SCC. The proposed studies will identify prognostic markers and therapeutic targets for high risk metastatic SCCs and simultaneously test interventional therapies that will be brought into clinic in the near future.

PI_NAMEs: WANG, XIAO-JING  (contact)

PROJECT_TERMS: Acceleration;Affect;Biological Models;biomarker identification;Blood Vessels;cancer stem cell;cancer type;candidate marker;Cause of Death;Cell Line;Cell Lineage;Cells;Cessation of life;Clinic;Coculture Techniques;Data;design;Disseminated Malignant Neoplasm;Distant Metastasis;driver mutation;Dyes;Exclusion;Exposure to;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Frequencies;Future;Gene Expression;Genetic;Genetically Engineered Mouse;Head and neck structure;Hematopoietic;high risk;high throughput screening;Human;Image;Immunocompetent;In Vitro;in vivo;inhibitor;innovation;Invaded;Keratin;knock-down;KRASG12D;Link;liquid biopsy;Lung;Malignant Epithelial Cell;Malignant Neoplasms;Melanoma;Metastatic Neoplasm to Lymph Nodes;Metastatic Neoplasm to the Lung;Metastatic Squamous Cell Carcinoma;migration;military veteran;Modeling;Molecular;molecular marker;Monitor;mouse model;Mus;Mutation;Myeloid Cells;nano-string;Neoplasm Metastasis;Neurons;Oral cavity;Organ;Outcome;Pathologic;Patients;pharmacologic;PI3 gene;PIK3CG gene;Population;Process;prognosis biomarker;Prognostic Marker;Property;Protein Array;protein biomarkers;Protein Secretion;restoration;Route;Side;single-cell RNA sequencing;Site;Skin;skin squamous cell carcinoma;Specimen;spectrograph;Squamous cell carcinoma;Squamous Cell Lung Carcinoma;stem cell expansion;stem cells;Stratified Epithelium;T-Lymphocyte;Testing;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Tobacco-Associated Carcinogen;Tongue;tool;TP53 gene;Transplantation;Travel;tumor microenvironment;tumor-immune system interactions;two-photon;ultraviolet irradiation;Veterans

PROJECT_TITLE: Mechanisms and Therapeutic Targets of SCC Metastasis


ADMINISTERING_IC: FD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative After a pet food recall due to melamine adulteration in 2007, the FDA has increasingly been called upon to expand the testing program that addresses the increasing threat to food safety and security through both naturally occurring pathogen outbreaks and intentional terrorism events. Partnership of FDA with Vet-LIRN laboratories can provides additional means of capacity building and capability enhancement to cope in the event of large-scale outbreak or threat incident. The Wisconsin Veterinary Diagnostic Laboratory is committed to participate in Vet-LIRN program to increase the network’s ability to examine samples from animals adversely affected by contaminated or adulterated products, and contribute to overall food safety as animal food events could signal potential issues in the human food system.

PI_NAMEs: LIM, AILAM LEE (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: Vet-LIRN Capacity Building for Increased Sample Analysis (U18)


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: FARGO

ORG_NAME: NORTH DAKOTA STATE UNIVERSITY

ORG_STATE: ND

PHR: PROJECT NARRATIVE The activities outlined in this agreement serve to better safeguard the human and animal food supply systems by enhancing the abilities of the member laboratory to provide analysis of Vet-LIRN samples in a timely and efficient manner.

PI_NAMEs: PECORARO, HEIDI LEE (contact)

PROJECT_TITLE: Vet-LIRN program cooperative agreement


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: AMES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Project Narrative The objective of this project is for the Iowa State University Veterinary Diagnostic Laboratory (ISU-VDL) to enter into a research cooperative agreement with the FDA CVM Vet-LIRN to enhance food safety and security efforts. It is of public health relevance because it will enhance proficiency in diagnostic testing of animal diseases caused by chemical contaminants. The ISU- VDL will participate in all activities in support of the FDA program to meet this public health need including sample analysis, providing analytical data to the FDA, participating in proficiency testing, validation and matrix extension of diagnostic methods, and by participating in the Vet- LIRN AMR Monitoring Program as a source laboratory.

PI_NAMEs: BORTS, DAVID  (contact)

PROJECT_TITLE: ISU Vet-LIRN Infrastructure Grant Proposal


ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative PAR-22-063 FOA is to solicit applications for inclusion into the FDA's Veterinary Laboratory Investigation and Response Network Cooperative Agreement Program (LIRN). The AzVDL has been a member of the NAHLN Network for 20 years and has the staff, experience, equipment and facilities to contribute to the LIRN.

PI_NAMEs: ZHANG, YAN  (contact)

PROJECT_TITLE: Enhance the security and resilience of the national food safety system


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Bacteria communicate through different signal transduction mechanisms, one of the least well understood of which is signaling through calcium ions. Here, we will begin to identify the components and roles of calcium signaling in the important human pathogen Mycobacterium tuberculosis.

PI_NAMEs: GRUNDNER, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Adopted;Bacteria;Bacterial Physiology;Calcium;Calcium Binding;Calcium Channel;Calcium ion;Calcium Signaling;Calcium-Binding Proteins;Cells;Cellular Stress;Chemicals;Communication;Cues;Data;Defect;Dependence;Eukaryota;Eukaryotic Cell;experimental study;Exposure to;Flow Cytometry;Fluorescence Resonance Energy Transfer;Growth;Homeostasis;human pathogen;Infection;inorganic phosphate;Kinetics;Knock-out;Ligand Binding;Ligands;Link;Macrophage;Maintenance;Maps;Mass Spectrum Analysis;Measures;Membrane;model organism;Mus;mutant;Mycobacterium tuberculosis;novel;Pathogenesis;Pathogenicity;Phenotype;Phosphorylation;Physiological;Physiology;protein profiling;Proteins;Proteome;Proteomics;Reporter;response;Role;Signal Transduction;Stress;System;Testing;Time;tool;uptake;VDAC1 gene

PROJECT_TITLE: Calcium signaling in Mycobacterium tuberculosis

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Adoptive T cell therapy has demonstrated tremendous potential for cancer treatment, but an incomplete understanding of T cell signaling makes manufacturing of these therapies expensive and inefficient. Because T cell signaling has been shown to be regulated by the nanoscale spatial organization of signaling structures, we propose to build DNA origami probes to present 3D patterns of signaling molecules to T cells with nanometer- scale precision. The public health benefit of this project will be to provide new insights into how T cell signaling is regulated by spatial arrangement and provide both knowledge and a platform for efficient manufacturing of therapeutic cell products for cancer immunotherapy.

PI_NAMEs: DOUGLAS, SHAWN M (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 3-Dimensional;Address;Adoptive Cell Transfers;Affect;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Autoimmune Diseases;Binding;Biochemistry;Biological Process;cancer immunotherapy;cancer therapy;cell behavior;Cell model;Cell Signaling Process;Cell surface;Cell Therapy;Cells;Cues;Dependence;Development;Diabetes Mellitus;Disease;DNA;engineered T cells;Engineering;Exclusion;extracellular;feasibility testing;Foundations;Goals;Health Benefit;Height;Human;Immune signaling;immunological synapse;immunological synapse formation;Immunotherapy;insight;interest;Interleukin-2;Knowledge;Lateral;Learning;Ligands;light microscopy;Linker DNA;Malignant Neoplasms;manufacture;Mediating;migration;nanopattern;nanoscale;Nanostructures;Nanotechnology;novel;Nucleotides;Pathway interactions;Patients;Pattern;Peptide/MHC Complex;Phosphotransferases;Positioning Attribute;Process;Production;programmed cell death protein 1;Public Health;Reagent;receptor;Resolution;Role;scaffold;Signal Pathway;Signal Transduction;Signaling Molecule;Single-Stranded DNA;stoichiometry;Structure;success;Surface;T cell regulation;T cell therapy;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Therapeutic;tool;two-dimensional;Work

PROJECT_TITLE: Probing mesoscale receptor organization in T cell signaling with DNA origami

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE This two-phase “health equity acceleration” U01 application is submitted to participate in the FDA OMHHE Health Equity Innovation Award for “Racial & Ethnic Minority Acceleration Consortium for Health Equity (REACH) (U01)” focused on advancing “minority health and health equity focused research, outreach, and communications as well as support training and mentoring of diverse HBCU advanced students, fellows, and researchers.” Two pilot projects/programs submitted in this application will be developed under Phase 1, and subsequently implemented under Phase 2: a) A Pilot curriculum on “Regulatory Issues and Health Equity” and potential FDA OMHHE rotations for advanced students and faculty in HBCUs in Pharmacy (XULA College of Pharmacy) and Nursing (Helene Fuld School of Nursing CSU); and b) A Pilot research project which will move the discussion beyond barrier identification to develop strategies to address barriers to clinical trial diversity, in order to increase trustworthiness, enhance transparency in sponsors and researchers, and bolster willingness to participate for African Americans, thereby strengthening equity in participation of underrepresented minority racial and ethnic groups in clinical trials.

PI_NAMEs: BAQUET, CLAUDIA R0SE (contact)

PROGRAM_OFFICER_NAME: LEE, CHRISTINE

PROJECT_TITLE: Racial and Ethnic Minority Acceleration for Health Equity Consortium U01


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH There is great need to diversify Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD) research cohorts, improve methods and tools for conducting health disparities research related to AD/ADRD, and examine other risk factors like obstructive sleep apnea (OSA), associated with higher AD-risk in older blacks, as this is critically needed to optimize patient care paradigms. In this innovative hypothesis-driven study, we will utilize a health disparities research framework related to aging to examine whether socio-structural determinants of health (SDOH) can help explain racial/ethnic heterogeneity in OSA-AD outcomes. The significance and impact of this proposal is strengthened by enrollment of a unique population of older blacks in which we will obtain neuroimaging measures of vascular burden, amyloid, and tau as well as nocturnal polysomnography (NPSG) recordings, and prioritize acquisition of SDOH data to elucidate disease mechanisms to aid future discovery of novel AD prevention targets and disease-modifying treatments.

PI_NAMEs: BUBU, OMONIGHO A MICHAEL (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: actigraphy;Address;Affect;African American population;Age;Aging;allostatic load;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Area;Behavioral;Black Populations;Black race;Blood Vessels;Body mass index;Brain;cardiovascular risk factor;Cerebrospinal Fluid;Clinical;Cognition;Cognitive;cohort;Communities;Data;deprivation;Diabetes Mellitus;Discrimination;Disease;disease disparity;disease model;Disease Outcome;Education;Eligibility Determination;Enrollment;entorhinal cortex;Ethnic Origin;Excessive Daytime Sleepiness;Exhibits;follow-up;Foundations;Future;health data;Health Disparities Research;Heterogeneity;High Prevalence;Home;Hypertension;IL17 gene;improved;in vivo;Income;indexing;Inferior;Inflammation;innovation;Interleukin-6;Investigation;Knowledge;Laboratories;late life;Lesion;Link;Magnetic Resonance Imaging;Measures;Mediating;Methods;Nerve Degeneration;neuroimaging;Neuropsychological Tests;new therapeutic target;Newly Diagnosed;non rapid eye movement;Not Hispanic or Latino;novel;Obstructive Sleep Apnea;older adult;Older Population;Onset of illness;Participant;Pathologic;Pathology;Patient Care;perceived stress;Plasma;Polysomnography;Population Heterogeneity;Positron-Emission Tomography;Public Health;Public Health Practice;Race;racial difference;recruit;Research;research clinical testing;Resources;Risk;Risk Factors;Sampling;Science;Severities;sex;Sleep;sleep quality;sleep regulation;Slow-Wave Sleep;social;social structure;Socioeconomic Status;Stress;stress management;structural health determinants;Surrogate Markers;tau Proteins;tau-1;Tauopathies;Temporal Lobe;Testing;therapy design;Thick;TNF gene;tool;United States National Institutes of Health;uptake;vascular risk factor;Visit;white matter;Work;β-amyloid burden

PROJECT_TITLE: Using a Health Disparity Research Framework to examine mechanisms linking Obstructive Sleep Apnea with higher Alzheimer’s disease risk in older Blacks/African-Americans

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE HIV infection is lifelong and there is no cure; most research on HIV cure has focused on a strain called subtype B HIV-1. In this R01 application, we propose to leverage an existing biobank of a previously NIH-funded Ugandan HIV cohort (UARTO), which houses 12360 blood cell samples collected longitudinally over ten years from 500 unique non-subtype B HIV-1-infected individuals to obtain and compare viral reservoir profiles associated with these non-B variants. We expect our results will inform whether HIV cure strategies should be subtype-specific.

PI_NAMEs: LEE, GUINEVERE  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: activating transcription factor;Address;Affect;Africa South of the Sahara;Anti-Retroviral Agents;antiretroviral therapy;Archives;base;Base Pairing;Binding;Binding Sites;biobank;Bioinformatics;Biological Assay;biological sex;Blood Cells;burden of illness;CD4 Lymphocyte Count;Cells;Centromere;Characteristics;Chromatin;Chronic;Clinical;Clonal Expansion;cohort;Communities;CXCR4 gene;Data;Databases;Demographic Factors;DNA;Epidemic;Ethnic Origin;Frequencies;Funding;Genes;Genetic Transcription;Genetic Variation;Genome;Genotype;HIV;HIV anti-retroviral;HIV Genome;HIV Infections;HIV-1;human DNA;Immune;Individual;Infection;Integration Host Factors;integration site;Interruption;Length;Link;Measures;mortality;Mutate;Mutation;Outcome;Patients;Plasma;Principal Investigator;Productivity;promoter;Promoter Regions;Property;Proviruses;receptor;Refractory;Research;RNA Sequences;Sampling;Technology;Therapeutic Effect;Time;Transcriptional Activation;United States National Institutes of Health;Variant;Viral;viral DNA;Viral Genome;viral rebound;Viral reservoir;viral RNA;Viremia;Virus;Virus Integration;Virus Latency;Virus Replication;whole genome

PROJECT_TITLE: Characterization of Non-subtype B HIV-1 Reservoirs and its Association with Longitudinal Clinical Outcomes

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Cardiovascular disease remains the major cause of morbidity in the US with the cost of care exceeding $555 billion in 2015 and as such, there has been a shift in emphasis from treatment of disease to the prevention of disease. Prevention of cardiovascular disease necessitates early detection and risk stratification, which may be facilitated by molecular and other multimodality imaging approaches allowing for a more precise and personalized approach to the evaluation and management of cardiovascular disease. For molecular imaging to emerge as a routine part of clinical practice, appropriate education within the cardiovascular physician community and training of a new breed of physicians and scientists is needed.

PI_NAMEs: DUNCAN, JAMES S;SINUSAS, ALBERT J (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TITLE: Training in Multi-Modality Molecular and Transitional Cardiovascular Imaging

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: MOUNTAIN VIEW

ORG_NAME: NEUROPACE, INC.

PHR: Project Narrative Lennox-Gastaut Syndrome (LGS) is a devastating form of childhood onset epilepsy characterized by cognitive dysfunction and very frequent generalized onset seizures (GOS) that often lead to injury. Driven by the lack of effective therapies and the demonstrated safety and efficacy of brain-responsive stimulation for treating medically intractable focal onset seizures, this study will test whether brain-responsive neurostimulation can also be used to treat LGS. The intent of the proposed research is to test the safety and preliminary efficacy of responsive neurostimulation of thalamocortical networks (RNS-TCN) involved in GOS, to identify promising detection and stimulation approaches, and to characterize neurophysiological biomarkers of clinical efficacy that will aid future research and clinical practice.

PI_NAMEs: MORRELL, MARTHA J (contact)

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: 12 year old;addiction;Adverse effects;atonic seizure;Bilateral;Biological Markers;biomarker discovery;biophysical model;blind;Blinded;Brain;Centromedian Thalamic Nucleus;Childhood;Clinical;clinical efficacy;clinical practice;Clinical Research;Clonic Seizure;cohort;computational network modeling;Computer Models;Crossover Design;Data;Death Rate;Decision Support Systems;Deep Brain Stimulation;design;Detection;Device Designs;Devices;diaries;Diffusion Magnetic Resonance Imaging;Disease;early experience;effective therapy;Electrodes;Electroencephalography;Electrophysiology (science);Elements;Enrollment;Epilepsy;Etiology;Evaluation;FDA approved;Feasibility Studies;Follow-Up Studies;Frequencies;Functional disorder;Future;Gastaut syndrome;Generalized Epilepsy;Genetic Crossing Over;Goals;Impaired cognition;Implant;improved;Injury;interactive therapy;Ipsilateral;Lead;lead optimization;Longterm Follow-up;Machine Learning;machine learning method;Magnetic Resonance Imaging;Manuals;Medial;Medical;Medical Imaging;Mental Depression;Modeling;neuroimaging;Neurons;neurophysiology;neuroregulation;novel;Online Systems;open label;Operative Surgical Procedures;Outcome;Parkinson Disease;Pathway interactions;Patients;Pharmaceutical Preparations;Physicians;Pilot Projects;Policies;Population;Post-Traumatic Stress Disorders;potential biomarker;predict clinical outcome;Prefrontal Cortex;prototype;Randomized;recruit;Research;response;Safety;safety testing;Seizures;Selection for Treatments;Single-Blind Study;System;Testing;Thalamic structure;Time;Tonic Seizures;tool;Update;Visualization

PROJECT_TITLE: Thalamocortical Responsive Neurostimulation for the Treatment of Lennox-Gastaut Syndrome


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE  The recent discovery of 291 new GPCRs, many of which have or are posited to have peptides as ligands, has inspired many structure-activity relationship and drug discovery campaigns that use peptides to understand and target these GPCRs; one of which is CXCR4. Unfortunately, the tools to investigate the SAR of these GPCRs and to develop effective peptide drugs are considerably lacking, relying on one-at-a-time chemical synthesis with a limited variety of amino acids. We aim to expand upon a novel synthetic platform developed by our lab to rapidly equip peptides with non-proteinogenic functionalities, thereby increasing their chemical and pharmacological complexity, and thus establish a brand-new way to evolve ordinary peptides as next-generation GPCR drugs.

PI_NAMEs: BLOOM, STEVEN  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Amino Acids;Anti-Retroviral Agents;Biology;chemical synthesis;Chemicals;Chemistry;Clinical;cost effective;Coupling;CXCR4 gene;design;Development;drug development;drug discovery;Drug Modulation;Drug Receptors;Drug Targeting;G-Protein-Coupled Receptors;Genus Mentha;GPR3 gene;HIV;Human;improved;Individual;Laboratories;Libraries;Ligands;Medicine;Methodology;Methods;new technology;next generation;novel;peptide analog;peptide drug;Peptide Library;Peptide Receptor;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;Procedures;Property;Solid;Structure-Activity Relationship;Synthesis Chemistry;Time;tool;Translating;unnatural amino acids;Variant

PROJECT_TITLE: New catalytic strategies to make non-proteinogenic peptides


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CALIFORNIA STATE UNIVERSITY LOS ANGELES

PHR: Project Narrative  This research aims to leverage state-of-the-art data-driven models for accurate estimation of protein-ligand binding afﬁnity that has wide applications in drug discovery. To this end, a physics-guided neural network has been introduced, which with adherence to the physical models, incorporates new structural features from the input complexes. The outcome of this research will improve the current understanding of protein-ligand interactions and will beneﬁt the computer-aided drug design.

PI_NAMEs: FOROUZESH, NEGIN  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Acceleration;Adherence;Affinity;Benchmarking;Binding;Binding Proteins;Biological;Biological Process;Biological Sciences;Cells;Characteristics;Chemicals;Communicable Diseases;Communities;Complex;Computer Assisted;Computer Models;Computer Simulation;Computing Methodologies;cost;Coupling;Data;data cleaning;data modeling;Data Set;data-driven model;Databases;design;DNA biosynthesis;drug candidate;Drug Design;drug discovery;drug-like compound;Ensure;experimental study;flexibility;foot;Free Energy;Gene Expression;Goals;graph neural network;GTP-Binding Proteins;Health;Human body;Hybrids;improved;Interdisciplinary Study;laboratory experiment;Ligands;loss of function;Machine Learning;Measures;Medicine;Methods;Modeling;Modernization;Modification;molecular recognition;neglect;neural network;Neural Network Simulation;novel;novel therapeutics;Outcomes Research;Performance;physical model;Physics;Play;Preparation;prevent;programs;Property;Protein Conformation;protein folding;Proteins;Protocols documentation;protonation;prototype;Research;response;Running;Sampling;Side;Signal Transduction;Signal Transduction Pathway;simulation;small molecule;Solvents;Source;Source Code;stem;structural biology;Structure;Study models;System;Techniques;Testing;Training;usability;virtual screening;Water;web services;Weight

PROJECT_TITLE: Improving the Accuracy of Implicit Solvents with a Physics-Guided Neural Network


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cancer;Clinical Research;Contraception/Reproduction;Fibroid Tumors (Uterine);Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Uterine fibroids (UFs; leiomyomas) are the most important benign neoplastic threat to women’s health worldwide. Current treatment options are limited beyond surgery, and the development of more effective medical therapies will require a better understanding of the underlying molecular pathogenesis of UFs. Accordingly, this proposal is impactful as it suggests a novel etiological basis to explain the development of MED12 mutation-positive UFs, the predominant UF subtype, through aberrant myometrial stem cell differentiation and transcription-dependent replication stress, and further offers proof-of-concept for therapeutic intervention using drugs that target the replication stress phenotype. The studies proposed herein thus address and mechanistically connect two overarching issues in the field: the pathogenesis of UFs and the development of non-hormonal treatment options.

PI_NAMEs: BOYER, THOMAS G (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Accounting;Address;atomic interactions;Benign;Binding;Biochemical;biological adaptation to stress;cell growth;Cell Reprogramming;cell transformation;Cells;Chemicals;Chromosomal Breaks;Chromosomal Instability;clinically relevant;crosslink;Cryoelectron Microscopy;Defect;Development;dosage;driver mutation;Drug Targeting;Drug usage;effective therapy;efficacy evaluation;Enhancers;Enzyme Kinetics;Enzymes;Etiology;Fibroid Tumor;Functional disorder;Gene Expression;Genetic;Genetic Transcription;Genetic Transformation;genome-wide;Genomic Instability;Habitual Abortion;Health Care Costs;Impairment;in vivo;Induced Mutation;Infertility;inhibitor;insight;Leiomyoma;Link;Mass Spectrum Analysis;Measures;Mediator;Medical;Menorrhagia;Mitotic;Molecular;Molecular Conformation;Monitor;Morbidity - disease rate;mouse model;Muscle;mutant;Mutation;Myometrial;neoplastic;novel;novel therapeutics;Operative Surgical Procedures;Output;Pathogenesis;Pathogenicity;Pathway interactions;Pelvic Pain;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Polymerase;pre-clinical;Pre-Clinical Model;Premature Labor;programs;promoter;Recurrence;replication stress;RNA Polymerase II;Role;Route;segregation;small molecule;Somatic Mutation;SOX8 gene;stem cell differentiation;stem cell fate;stem cell self renewal;stem cells;stress kinase;Structural Biochemistry;structural biology;Structure;Testing;Therapeutic;Therapeutic Intervention;transcription factor;Transcription Initiation;Transcriptional Regulation;Treatment Efficacy;tumor;tumor growth;tumor initiation;tumor progression;tumorigenic;Uterine Fibroids;Women's Health

PROJECT_TITLE: Molecular basis of MED12 in the pathogenesis of uterine fibroids


ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: PROJECT NARRATIVE This proposal seeks the establishment of the Puerto Rico Racial & Ethnic Minority Acceleration Consortium for Health Equity (PR-REACH) to support the advancement of Hispanic Puerto Ricans health equity, this is a first step in a research agenda to collaborate with the Food and Drug Administration (FDA) Office of Minority Health and Health Equity (OMHHE) across REACH research projects and activities by first building an administrative research and communication infrastructure; leadership team, three EQUITY research cores (Clinical Trials, Voices and Data), a training and mentoring core, and an advisory team. A pilot study under this consortium will be conducted to advance the understanding of substance use disorder patients’ journey as perspectives, preferences and unmet needs regarding substance use disorder (SUD) treatment with FDA approved medications in PR to be able to improve its outcomes and launch PR-REACH in PR. The PR-REACH will initiate with Hispanics living in Puerto Rico as a model than can inform and guide subsequent extrapolation to Hispanics in the US in collaboration with the FDA.

PI_NAMEs: MARTINEZ GONZALEZ, KAREN G.;SANTIAGO, DARLENE I (contact)


ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE  The advent of remote technologies such as video conferencing and secure web-portals have revolutionized approaches to health data collection and access to healthcare, where these technologies can be deployed in fully remote and hybrid approaches for clinical trials which could help promoting more participation among under-represented groups as well as by bridging geographic distance and reducing participant burden (e.g., less travel time, more flexibility and confidentiality). However, these approaches have yet to be optimized for all possible beneficiaries of technological advances in clinical trials and healthcare, especially targeting under- represented populations that are disproportionately experiencing social and geographic isolation. To address these concerns, the current proposal seeks to leverage the team’s existing community connections in states across 4 different regions of the U.S. among the Asian American and Pacific Islander (including Native Hawaiian), American Indian, Hispanic/Latino, and sexual and gender minority populations to: (1) (a) co-create and maintain 4 virtual and hybrid advisory groups to address health issues and (b) develop materials for the conduct of remote advisory groups; (2) co-develop and administer a national needs assessment survey for the referenced 4 groups (N = 800) addressing the use of home self-testing technology (up to 3 types) and remote data collection for healthcare research and healthcare provision; and (3) pilot community driven approaches to introducing home self-testing technology and remote data collection to potential participants from these groups to assess feasibility and acceptability.

PI_NAMEs: FLORES MILLENDER, EUGENIA  (contact);WONG, FRANK Y.;XAVIER HALL, CASEY DANIEL

PROJECT_TITLE: Elevating Community Voices by Developing a User-centered Approach to Enable Self-testing and Remote Data Collection among Under-represented Populations (Project Elevate)


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: NARRATIVE High-throughput technology and electronic health records (EHRs) have dramatically increased the amount of data that can used for better understanding and new treatments of disease. However, analyzing the data generated by these technologies requires significant quantitative and computational expertise. Our goal is to develop a program to train current and upcoming generations of diverse biomedical researchers in the skills needed to fully mine the potential of the large amount of available data, and put it to use in furthering diagnosis and treatment of disease, and promoting public health.

PI_NAMEs: PAPP, JEANETTE CHRISTINE;SOBEL, ERIC  (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: academic program;Asian Americans;Big Data;Big Data Methods;biobank;California;career;Collaborations;Computing Methodologies;Consult;Country;Data;Data Analyses;Data Set;design;Diagnosis;Disease;Distance Learning;Education;Educational process of instructing;Educational workshop;Electronic Health Record;Enrollment;Event;Exercise;experience;Exposure to;Faculty;Faculty Workshop;Future;Generations;genome sciences;genomic data;Genomics;Goals;Grant;handheld mobile device;health data;high throughput technology;Hispanic-serving Institution;Historically Black Colleges and Universities;Home;Human;Institution;interest;Knowledge;Leadership;learning materials;lectures;Los Angeles;Mathematical Biology;Mathematics;medical specialties;Medicine;member;Mentors;method development;Methods;Minority-Serving Institution;next generation;outreach;outreach program;Pacific Islander;Participant;Postdoctoral Fellow;Precision Health;Problem Solving;programs;Public Health;Research;Research Personnel;Research Training;Resources;Scholarship;Science;Scientist;Series;Site;skills;Statistical Methods;statistics;symposium;Teaching Materials;Techniques;Technology;theories;tool;Training;tribal college;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Universities;Update;wearable device

PROJECT_TITLE: Workshops on Genomics and Next Generation Computational Statistics for Big Data

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The fundamental goal of the proposed study is to determine the potential of a bacterial-derived toxin (from the oral pathogen Aggratibacter actinomycetemcomitans), the cytolethal distending toxin (Cdt), to alter host defenses. Specifically, this study focuses on a novel role for this toxin in perturbing human macrophage function including inducing a pro-inflammatory response and impairing phagocytosis. We propose that this response contributes to the pathogenesis of inflammatory disorders such as periodontal disease.

PI_NAMEs: BOESZE-BATTAGLIA, KATHLEEN ;SHENKER, BRUCE J (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Actinobacillus actinomycetemcomitans;adaptive immune response;Antigens;Apoptosis;Apoptotic;Arachidonic Acids;Binding;Carrier Proteins;Caspase;Cell Cycle Arrest;Cell Line;Cell Physiology;Cell Proliferation;cell type;Cells;cellugyrin;Cessation of life;Cholesterol;Chronic;Complex;cytokine;cytolethal distending toxin;Defect;Dinoprostone;Disease;Eicosanoids;Endosomes;Epithelial Cells;Event;Exhibits;Goals;Heat shock proteins;Heat-Shock Proteins 90;holotoxins;Host Defense;Human;IL18 gene;Immunotoxins;Impairment;Individual;Infection;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;Innate Immune Response;insight;Interleukin-6;Intoxication;Investigation;Knowledge;Link;Lipids;Lymphocyte;Lytic;Macrophage;Mediating;Membrane Lipids;Membrane Microdomains;Microbe;microbial;Molecular;monocyte;Movement;novel;oral pathogen;Organism;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Periodontal Diseases;Periodontitis;Phagocytes;Phagocytosis;Phagolysosome;Phagosomes;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Phosphorylation;PI3 gene;PIK3CG gene;Play;Production;Property;Prostaglandin-Endoperoxide Synthase;Proteins;repaired;Research;response;retrograde transport;Role;Signal Pathway;Signal Transduction;small molecule;Sorting;spatiotemporal;synaptogyrin;System;Targeted Toxins;Testing;Therapeutic Intervention;Thromboxanes;Toxic effect;Toxin;trafficking;Translating;tripolyphosphate;vesicle transport;virtual;Virulence Factors

PROJECT_TITLE: A. Actinomycetemcomitans Cdt Induces Pro-Inflammatory Innate Immune Responses

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Lung;Orphan Drug;Pediatric;Precision Medicine;Pulmonary Hypertension;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Pediatric patients with congenital heart disease commonly develop complex peripheral pulmonary artery stenosis (PPS) which can lead to right ventricular failure, pulmonary blood flow imbalance, and even death. While surgical treatment of PPS has led to favorable outcomes at select centers, catheter-based interventions remain the current standard of care at most institutions despite unfavorable and unpredictable outcomes. There is an urgent need for personalized treatment planning and improved outcomes in PPS patients. We propose an integrated modeling and experimental approach in which mechanical tissue testing and clinical data collection will inform and validate two complementary computational models: a mechanistic model of pulmonary flow, growth, and remodeling and a real-time uncertainty-aware “digital twin” model for optimal treatment planning, with the ultimate goal to improve patient outcomes.

PI_NAMEs: FEINSTEIN, JEFFREY A.;MARSDEN, ALISON L (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Affect;Aftercare;Age;Alagille Syndrome;Angioplasty;Arteries;artery stenosis;Awareness;Balloon Angioplasty;Basic Science;Bayesian Method;Bayesian Modeling;Biological;Biomechanics;Biomedical Engineering;Blood flow;Blood Vessels;Cardiac Catheterization Procedures;Cardiovascular system;Catheters;Cessation of life;Characteristics;Childhood;Clinical;Clinical Data;clinical decision support;clinical decision-making;clinically relevant;Complex;Complication;Computer Models;congenital heart abnormality;Coupling;Data;Data Collection;digital twin;Disease;Disease Progression;Distal;Engineering;Ensure;experimental study;Formulation;Foundations;Goals;Growth;hemodynamics;Histologic;Histology;homograft;Hour;Human;human data;human disease;Hypertension;improved;improved outcome;individual patient;Infant Mortality;Institution;Intervention;intervention effect;Lesion;Liquid substance;Literature;Lobar;Lung;Machine Learning;mechanical properties;Mechanics;Membrane;Methods;Modeling;Morbidity - disease rate;Morphology;mortality;multi-scale modeling;novel;Operative Surgical Procedures;optimal treatments;Outcome;Pathologic;patient population;Patient-Focused Outcomes;Patients;Pediatric cardiology;pediatric patients;Peripheral;personalized medicine;Physics;Physiologic intraventricular pressure;Physiological;Population;post intervention;Postoperative Period;Prediction of Response to Therapy;predictive modeling;Procedures;Property;pulmonary arterial pressure;Pulmonary arterial remodeling;Pulmonary artery structure;Pulmonary Valve Stenosis;reconstruction;Reconstructive Surgical Procedures;right ventricular failure;Severities;simulation;soft tissue;Solid;standard of care;Statistical Models;Stenosis;Stents;Structure;success;support tools;Testing;Tetanus Helper Peptide;Tetralogy of Fallot;theories;Time;Tissue Model;Tissues;Training;treatment comparison;treatment optimization;Treatment outcome;treatment planning;treatment strategy;Trees;Uncertainty;Unnecessary Procedures;vascular abnormality;Ventricular;virtual model;virtual therapy;Work

PROJECT_TITLE: Uncertainty aware virtual treatment planning for peripheral pulmonary artery stenosis

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Heart Disease;Kidney Disease;Prevention

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Aortic stenosis (AS), involving progressive calcification and narrowing of the aortic valve, the main outlet of the heart, is common and universally fatal without treatment with surgery to replace the aortic valve, as no medical therapy has been proven to prevent or slow progression of AS. In this setting, the presence of concomitant chronic kidney disease has been associated with higher rates of and complications from AS on account of rapid and early calcification of the aortic valve and blood vessels. This study seeks to understand the risk factors that are most important in AS progression as well as identify ways to identify those who progress more quickly and how AS progression associates with adverse cardiovascular outcomes using data from Chronic Renal Insufficiency Cohort Study, an NIDDK-sponsored population cohort study of individuals with chronic kidney disease, and the Atherosclerosis in Communities Study, an NHLBI-sponsored population cohort study of individuals, the majority of whom have normal kidney function.

PI_NAMEs: STROM, JORDAN BLAIR (contact)

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Address;adjudication;Adult;Age;aged;Albuminuria;Aorta;aortic valve;aortic valve replacement;Aortic Valve Stenosis;Atherosclerosis;Atherosclerosis Risk in Communities;Atrial Fibrillation;Biological;Biological Markers;Biological Models;Blood Pressure;Blood Vessels;calcification;Calcium;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chest;Chronic Kidney Failure;Chronic Kidney Insufficiency;Clinical;Clinical Data;clinical risk;cohort;Cohort Studies;Communities;comparative;coronary calcium scoring;Data;Development;Diabetes Mellitus;Dialysis patients;Dialysis procedure;Disease;Echocardiography;Effectiveness;Enrollment;Etiology;Fibrinogen;Funding;General Population;glomerular filtration;Goals;Heart;Heart failure;Heart Valve Diseases;hemodynamics;human old age (65+);Image;improved;Individual;inorganic phosphate;insight;inter-individual variation;Interleukin-6;Kidney Diseases;Knowledge;Link;Lipoprotein (a);Measures;Medical;Modeling;mortality risk;Myocardial Infarction;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Observational Study;Obstruction;Operative Surgical Procedures;Outcome;Participant;Patients;Perioperative;Peripheral arterial disease;Phenotype;Physiologic pulse;Physiology;Population;population based;pre-clinical;premature;prevent;prospective;Prosthesis;Race;Renal function;Reporting;Research;Risk;Risk Factors;risk prediction;Serum;Severities;Severity of illness;sex;Stroke;Testing;TNF gene;Tobacco smoking behavior;Transforming Growth Factor beta;Visit;α-Fetoproteins

PROJECT_TITLE: Chronic Renal Insufficiency and Silent Progression of Aortic Stenosis (CRISP-AS)

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Rehabilitation

ORG_DEPT: NEUROLOGY

PHR: Project Narrative The process of mapping acoustic signals onto units of syllables, words, and phrases is essential to human communication and is also remarkably difficult to replicate in machine systems. We propose an approach that leverages novel speech paradigms, computational modeling and invasive neural measures in neurosurgical patients in order to characterize human cortical speech perception. Using these complementary approaches in tandem with high resolution recording, we will greatly advance our understanding of how speech is processed and temporal information is integrated over time in various parts of cortex in in the hopes that our findings will inform new therapeutic strategies for a range of speech communication impairments.

PI_NAMEs: FLINKER, ADEEN  (contact);MESGARANI, NIMA

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustic Nerve;Acoustics;Address;Anatomy;Area;Auditory;Auditory area;auditory pathway;behavior observation;Behavioral;Behavioral Research;Brain;Categories;cohort;Communication;Communication impairment;Communities;Complex;Computer Models;Data;deep neural network;density;design;Dimensions;Discipline;Early identification;experimental study;Focal Brain Injuries;Heterogeneity;Human;human model;Impairment;Implanted Electrodes;interest;Language Disorders;learning network;lexical;Linguistics;Link;Maps;Measures;Methods;millisecond;Modeling;Nature;neural;Neural Network Simulation;Neurobiology;neuroimaging;neurophysiology;neurosurgery;New York;novel;novel therapeutic intervention;pandemic disease;Patients;Pattern;Phonetics;phonology;phrases;Process;Prosthesis;receptive field;Research;Research Personnel;Resolution;response;Route;Scheme;Semantics;Signal Transduction;sound;spatiotemporal;Speech;Speech Disorders;Speech Pathology;Speech Perception;speech processing;speech recognition;Speech Sound;Stimulus;Structure;Surface;syntax;System;Techniques;Technology;temporal measurement;Testing;Time;Universities

PROJECT_TITLE: Characterizing the temporal processing of speech in the human auditory cortex

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Telehealth

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Narrative Appalachia is a socially and economically disadvantaged part of the US. Gay, bisexual, and other men who have sex with men (GBMSM) and transgender women in rural Appalachia are at increased risk for HIV, sexually transmitted infections (STIs), and hepatitis C virus (HCV), and yet, little research has been conducted to understand and reduce health disparities among these vulnerable, hidden, and neglected populations in the region. We propose to systematically integrate two evidenced-based strategies (i.e., peer navigation and mHealth) into a comprehensive culturally congruent, bilingual intervention to increase the use of needed HIV, STI, and HCV prevention and care services among racially/ethnically diverse GBMSM and transgender women in rural Appalachia.

PI_NAMEs: RHODES, SCOTT D (contact);TANNER, AMANDA E

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Appalachian Region;Behavior assessment;bilingualism;Bisexual;care systems;Caring;Clinic;Communities;community based participatory research;Community Health;community organizations;comparison group;comparison intervention;Country;Coupled;Data;design;economic disparity;efficacious intervention;empowerment;Enrollment;Ensure;Epidemic;ethnic diversity;Ethnic Origin;evidence base;follow-up;Gays;gender affirming care;gender minority community;group intervention;Health;health disparity;Hepatitis C Therapy;Hepatitis C virus;HIV;improved;innovation;Intervention;Interview;member;men who have sex with men;mHealth;neglect;Participant;peer;Policies;Population;post intervention;pre-exposure prophylaxis;Prevention;prevention service;Process;Public Health Practice;Race;racial diversity;Randomized;randomized trial;Recommendation;recruit;Reduce health disparities;Research;research study;Rest;Risk;Rural Appalachia;Rural Population;rural setting;Science;service organization;Services;sexual minority community;Sexually Transmitted Diseases;social disparities;social media;Social Network;success;Syringes;Testing;theories;therapy development;Training;transgender;transgender women;trial design;Universities;uptake;virus testing

PROJECT_TITLE: Harnessing the power of peer navigation and mHealth to reduce health disparities in Appalachia


ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA COMMUNITY HEALTH CTR/ASSN

PHR: NARRATIVE: Increasing the diversity of clinical trial participants is key to advancing health equity. This project aims to increase the recruitment of diverse participants in research through established provider and community health worker relationships in minority communities using new, interactive community driven curricula.

PI_NAMEs: HAYES, REBECCA  (contact)

PROJECT_TITLE: Improving Multicultural Engagement in Clinical Research through Partnership with Federally Qualified Health Centers and Community Health Worker Programs


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: DAVIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE - Overall The National Center for Interventional Biophotonic Technologies (NCIBT) will promote public health by improving the clinical management of a broad range of common human conditions, including cancer, stroke, heart disease, high risk pregnancy, and dementia. Its advanced optical imaging devices will better characterize tissue structure and function and its AI-based analytical intraprocedural platform will integrate these imaging data and other patient-specific information into algorithms guiding treatment decisions. The availability of such helpful guidance as procedures are being performed or critical decisions are being made should help physicians make better choices that lead to improved patient outcomes.

PI_NAMEs: HARSH, GRIFFITH R.;MARCU, LAURA  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Acceleration;Acute;Address;Algorithms;analytical tool;Area;Biophotonics;Cardiology;Cerebrovascular Circulation;Clinical;clinical application;clinical decision-making;Clinical Management;clinical translation;Cognition;Collaborations;commercialization;Communities;computerized tools;Data;data streams;Decision Making;deep learning;Degenerative Disorder;Dementia;design;Development;Diagnosis;Diffuse;Diffusion;Disease Management;Educational workshop;Electronic Mail;Engineering;Ensure;Equipment;Fetal health;fluorescence lifetime imaging;General Population;global health;Goals;Hand;Health;Heart Diseases;High-Risk Pregnancy;holistic approach;Human;Humanities;Image;image guided;Imaging Device;imaging modality;imaging platform;Imaging Techniques;Imaging technology;Immersion;improved;Individual;individualized medicine;industry partner;Infection;innovation;Institution;instrument;interest;Intervention;Legal patent;Link;Literature;Malignant Neoplasms;Medical;Medical center;Medical Societies;Medicine;meetings;Metabolism;Monitor;Near-Infrared Spectroscopy;Nervous System Disorder;novel;open source;Ophthalmology;optical imaging;Optics;Participant;Patient-Focused Outcomes;Patients;Perfusion;photonics;Physicians;precision medicine;Procedures;Program Development;program dissemination;programs;Property;Public Health;Publications;Research;Research Project Grants;residence;Resolution;Schools;Scientist;Services;social media;Source;Spectrum Analysis;Speed;Stroke;Structure;Surgeon;Surgical Oncologist;Surgical Oncology;symposium;System;Technology;technology development;technology training;Therapeutic;Time;Tissues;Training;Training Programs;Translations;Trauma;Traumatic Shock;tumor;Vision;Visit;Visualization;web site;Work


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PI_NAMEs: MARCU, LAURA  (contact)

PROJECT_TERMS: Accounting;Address;Administrator;Area;authority;Biophotonics;Businesses;Collaborations;Communication;computer infrastructure;data sharing;design;Education;Equipment;Evaluation;experience;Fostering;Funding;Goals;Human Resources;Institution;Intervention;Investigation;Leadership;member;National Institute of Biomedical Imaging and Bioengineering;operation;organizational structure;Performance;Personnel Management;Physicians;Policies;Procedures;program dissemination;programs;Protocols documentation;recruit;Regulation;Reporting;Research;Resources;Scientist;Selection Criteria;Services;synergism;Technology;technology development;technology research and development;technology training;Training;United States National Institutes of Health;University resources;Work

PROJECT_TITLE: Administrative Core


PROJECT_TERMS: Address;Adoption;advanced analytics;analytical method;animal imaging;Architecture;Biochemical;Biochemistry;Biophotonics;Biopsy;Brain;Breast;Calibration;Cardiovascular system;Catheters;Cell Culture Techniques;Classification;Clinical;clinical imaging;Collection;Complex;complex data;cost effective;Coupling;Data;data acquisition;Data Aggregation;Data Analyses;data streams;Databases;Decision Making;deep learning;design;Detection;detector;Development;Devices;Diagnosis;Diagnostic;Electronics;Engineering;Evaluation;Excision;Fiber;Fiber Optics;Fluorescence;fluorescence lifetime imaging;Head and neck structure;imaging detector;Imaging Device;imaging modality;imaging system;Imaging technology;improved;In Situ;innovation;instrumentation;Intervention;Knowledge;Label;Light;Link;Measurement;Mechanics;Metabolic;Methodology;microendoscopy;Microscopy;miniaturize;minimally invasive;Modality;Molecular;Molecular Probes;Morphology;Multi-Institutional Clinical Trial;Multimodal Imaging;Nervous System Disorder;Normal tissue morphology;Operative Surgical Procedures;optical imaging;Optics;Organ;Pathologic;Pattern;Performance;photonics;Procedures;Property;Prostate;Protocols documentation;prototype;quantitative imaging;Site;Spectrum Analysis;Speed;Standardization;Surgeon;surgery outcome;Surgical Oncology;synergism;Techniques;Technology;technology research and development;Time;Tissue Transplantation;Tissues;Translating;tumor

PROJECT_TITLE: TRD1: Interventional Fluorescence Lifetime Imaging Microscopy (iFLIM)


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Contraception/Reproduction;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE This new application for Margo Minissian, PhD, ACNP incorporates a multi-disciplinary, mentored patient- oriented research plan to facilitate independence as a nurse scientist, generate preliminary evidence and facilitate an R01 application. This comparative, longitudinal study will compare vascular and cardiac structure/ function and novel cardiac biomarkers in mothers who had term preeclampsia (TPre), spontaneous preterm delivery (sPTD) and preterm preeclampsia (PreE) compared to full-term controls. The outcome of this research will inform relationships between TPre, sPTD and PreE which is an important step to uncover the link between adverse pregnancy outcomes and future maternal atherosclerotic cardiovascular disease (ASCVD) risk.

PI_NAMEs: MINISSIAN, MARGO  (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: Address;adverse outcome;adverse pregnancy outcome;Aorta;arterial stiffness;Atherosclerosis;atherosclerosis risk;Award;Biological Markers;Blood Vessels;Cardiac;cardiac magnetic resonance imaging;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular Physiology;Cardiovascular system;Categories;Cause of Death;Cessation of life;Chronic;Circulation;Clinical;Collection;comparative;coronary fibrosis;Data;Data Set;Development;Diabetes Mellitus;Discipline of Nursing;Disease;Disease Pathway;Doctor of Philosophy;Elasticity;epidemiology study;experience;Fibrosis;follow-up;Future;Goals;Heart failure;heart function;Hour;Hyperlipidemia;Hypertension;Imaging Techniques;indexing;Individual;innovation;insight;Intervention;Lead;Left;Left Ventricular Dysfunction;Link;Lipids;Longitudinal Studies;Malignant Neoplasms;Maps;Matrix Metalloproteinases;Measures;Mentors;Metalloproteases;Mothers;multidisciplinary;Muscle Tonus;Myocardial dysfunction;National Institute of Nursing Research;novel;Nurses;outcome prediction;Outcomes Research;Pathway interactions;patient oriented research;Perinatal;Phenotype;Physiologic pulse;Physiology;Placenta Diseases;Population;Postpartum Period;pre-clinical;Pre-Eclampsia;Pregnancy;Premature Birth;Proteins;Proteomics;Publications;Recording of previous events;Reporting;Research;Research Design;Research Personnel;response;retention rate;Risk;Risk Factors;Sampling;Science;Scientific Advances and Accomplishments;Scientist;Severities;Shapes;Structure;symptom science;Symptoms;Testing;Time;Tissues;Training;Transforming Growth Factors;Translating;translational scientist;Vascular Diseases;Vascular Smooth Muscle;vasoconstriction;Vasodilation;Ventricular;Woman;Women's Health;Women's mortality;women's outcomes

PROJECT_TITLE: Is Preeclampsia and Spontaneous Preterm Delivery Associated with Vascular and Cardiac Function?

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(74)]


PI_NAMEs: SRINIVASAN, VIVEK JAY (contact)

PROJECT_TERMS: Abdomen;Address;Adoption;Adult;analytical method;Area;Benign;Biochemical;Biophotonics;Blood;Blood flow;blood flow measurement;Blood Pressure;Brain;brain computer interface;Brain imaging;Caring;cerebrovascular;Cerebrovascular Circulation;Clinical;clinical application;Collaborations;Compensation;cost;cranium;Critical Care;data streams;Delivery Rooms;Democracy;density;Detection;detector;Development;Device or Instrument Development;Devices;Diffuse;Diffusion;Discipline of obstetrics;experience;Fetal Monitoring;Fiber;Flowmetry;heart rate monitor;hemodynamics;Hemoglobin;Image;imaging approach;imaging modality;imaging platform;improved;indexing;Infrared Rays;innovation;instrumentation;Interferometry;Intervention;invention;Lasers;Light;light scattering;Link;Magnetic Resonance Imaging;Measurement;Measures;Medicine;Metabolic;Metabolism;metal oxide;Methods;Microsurgery;millimeter;Modality;Monitor;Morphologic artifacts;Motion;multimodality;Near-Infrared Spectroscopy;Neurosciences;Noise;non-invasive monitor;non-invasive optical imaging;novel strategies;Operative Surgical Procedures;Optical Coherence Tomography;Optics;parallelization;Performance;Perfusion;Perinatal;Photons;Physics;Physiological;Physiology;point of care;Population;Positioning Attribute;prevent;Property;Randomized;Reconstructive Surgical Procedures;Resolution;Scalp structure;Scanning;screening;Semiconductors;sensor;Services;Site;skill acquisition;skills;Source;Specificity;Spectrum Analysis;Standardization;Stroke;synergism;System;Technology;technology research and development;Time;tissue oxygenation;Tissues;Traumatic Brain Injury;wearable device

PROJECT_TITLE: TRD2: Interferometric Near Infrared Spectroscopy (iNIRS)


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Cardiovascular disease (CVD) results in 40% of all deaths and results in serious morbidity in both men and women and it is well known that a key early step in the development of CVD is dysfunction of a thin single-cell layer of cells lining the inner wall of the blood vessels called endothelium. Our goal is to determine the mechanisms responsible for the impairment of endothelial function by hypercholesterolemia, focusing on cholesterol-induced suppression of a specific type of endothelial K+ channel that we showed to play a significant role in endothelial dysfunction. Currently we focus on elucidating the mechanism of how cholesterol binding to the channels impairs their function (a fundamental and still unanswered question), the role of cholesterol-induced suppression of these channels in endothelial dysfunction, and the impact of the loss of function of these channels on atherosclerosis development, which we believe will contribute significantly to the understanding of endothelial dysfunction and provide the basis for new therapeutic approaches.

PI_NAMEs: LEVITAN, IRENA  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Address;Aorta;Apolipoprotein E;atheroprotective;Atherosclerosis;Binding;Binding Sites;Biochemical;Blood Vessels;Cardiovascular Diseases;Cell Line;Cells;Cessation of life;Cholesterol;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;computer studies;Cytoskeleton;Data;Dependovirus;Descending aorta;Development;Down-Regulation;Dyslipidemias;Electrophysiology (science);Endothelial Cells;endothelial dysfunction;Endothelium;Functional disorder;Funding;gain of function;Gene Expression;Genetic;Goals;Grain;Grant;High Density Lipoproteins;Human;Hydrophobicity;hypercholesterolemia;Impairment;In Vitro;in vivo;Individual;Injury;insight;inward rectifier potassium channel;Ion Channel;KDR gene;Kir2.1 channel;Lesion;loss of function;Low-Density Lipoproteins;Mediating;men;Modeling;Molecular;molecular dynamics;molecular scale;Monomeric GTP-Binding Proteins;Morbidity - disease rate;mouse model;Mus;mutant;Mutation;Neutrons;novel;novel therapeutic intervention;overexpression;PECAM1 gene;Phenotype;Phospholipids;Phosphorylation;PIK3CG gene;Plasma;Play;Potassium Channel;predictive modeling;Process;Proteins;Radiolabeled;Regulation;Research;response;Risk Factors;Role;Signal Transduction;simulation;Site-Directed Mutagenesis;Testing;Thinness;transcriptome sequencing;Transgenic Model;Transgenic Organisms;Translating;Transmembrane Domain;Vasodilation;Woman

PROJECT_TITLE: Cholesterol Regulation of Endothelial K+ Channels

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Precision Medicine

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative At the most basic level, social communication boils down to what you say and what you do while interacting with other people. Problems with social communication affect individuals with ASD throughout their lives, but expensive and time-consuming measurement tools have hindered the development of effective treatments for this core challenge. In this proposal, we aim to improve clinical characterization and diagnostic decision- making in ASD and other psychiatric conditions by digitizing human vocal interaction and using advanced machine learning techniques to fuse audio-video signals into an autism-specific algorithm, thus laying the groundwork for future precision medicine efforts and advancing the state of public health.

PI_NAMEs: PARISH-MORRIS, JULIA  (contact)

PROJECT_TERMS: Acoustics;Adolescent;Affect;Algorithms;Autism Diagnosis;autism spectrum disorder;automated speech recognition;Behavior;Caring;Classification;Clinical;clinical care;clinical outcome measures;Clinical Treatment;Clinical Trials;cognitive process;Companions;Complex;Computational Linguistics;Computer Vision Systems;Consumption;Control Groups;data fusion;Decision Making;design;Development;Diagnosis;Diagnostic;digital;Dimensions;Disease;dyadic interaction;effective therapy;Face;Facial Expression;Frequencies;Funding;Furuncles;Future;genetic association;Genetic study;Human;improved;Individual;Individual Differences;individuals with autism spectrum disorder;Language;Left;Machine Learning;machine learning classification;machine learning classifier;machine learning model;Measurement;Measures;meetings;Mental disorders;Mental Health;Methods;Modality;Modeling;Monitor;Motor;motor behavior;multimodal fusion;multimodality;National Institute of Mental Health;National Institute on Deafness and Other Communication Disorders;natural language;non-verbal;novel;Outcome Measure;Output;Participant;Persons;Phenotype;Pilot Projects;precision medicine;Public Health;Research;Sampling;Signal Transduction;skills;social;Social Behavior;social communication;social deficits;Social Interaction;sound;Specificity;Stream;Techniques;Teenagers;Testing;Time;tool;trait;verbal

PROJECT_TITLE: Digitizing Human Vocal Interaction to Understand and Diagnose Autism

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_STATE: CA

PI_NAMEs: QI, JINYI  (contact)

PROJECT_TERMS: 3-Dimensional;Address;advanced analytics;analytical method;Artificial Intelligence;artificial intelligence algorithm;Biophotonics;blood flow measurement;Classification;Clinical;clinical care;Clinical Data;clinical decision-making;Comprehension;Computer Assisted;Critical Care;Data;data acquisition;Data Analytics;data integration;data modeling;Data Science;data streams;data visualization;Decision Making;Decision Support Systems;deep learning;design;Detection;Discipline of obstetrics;Disease;Electroencephalography;Expert Systems;Feedback;fluorescence lifetime imaging;heterogenous data;Human;Image;Image Analysis;image processing;imaging system;improved;Individual;individual patient;instrument;instrumentation;Intensive Care;interactive visualization;Intervention;Intuition;Learning;Machine Learning;machine learning model;Magnetic Resonance Imaging;Medical;Medical History;Medical Imaging;Methodology;Modality;Modeling;Monitor;monitoring device;multimodal data;Multimodal Imaging;multimodality;Operative Surgical Procedures;optical imaging;Optical Instrument;Optics;optimal treatments;Outcome;Pathologic;Pathologist;Patient-Focused Outcomes;Patients;Performance;personalized care;personalized intervention;personalized medicine;PET/CT scan;Physicians;Positron-Emission Tomography;Postoperative Period;Procedures;Qi;radiologist;Radiology Specialty;Research;Resource Sharing;response;Sampling;Science;Series;signal processing;Signal Transduction;Surgeon;synergism;System;Techniques;Technology;technology research and development;Time;tool;Veterinary Surgery;Visual;Visualization;Visualization software

PROJECT_TITLE: TRD3: Data Analytics and Intelligent Systems (AI-ML-DL-Visualization)


PI_NAMEs: HARSH, GRIFFITH R. (contact)

PROJECT_TERMS: analytical tool;Attention;Awareness;Biophotonics;Categories;Center for Translational Science Activities;Clinical;clinical application;Clinical Data;clinical implementation;Clinical Protocols;Clinical Research;Clinical Sciences;cohort;commercialization;Communities;Computer software;cost;cost effective;Data;design;Devices;Education;Educational workshop;efficacy evaluation;Electronic Mail;Engineering;Equipment;Exercise;Faculty;Future;Goals;holistic approach;Human Resources;imaging scientist;improved;Industry;Institution;instrument;interest;Intervention;investigator training;Knowledge;Laboratory Study;Legal patent;Link;Medical;Medical Societies;Medical Students;meetings;member;Methodology;Newsletter;open source;Participant;Physicians;posters;pre-clinical;Production;Productivity;program dissemination;programs;Publications;Publishing;Research Personnel;Schools;Science;Scientific Societies;Scientist;skills;social media;Sterility;symposium;Techniques;Technology;technology training;tool;Training;Training Programs;Translational Research;Underrepresented Minority;Visit;web site;Woman;Work

PROJECT_TITLE: Technology Training and Dissemination


ORG_CITY: HONOLULU

ORG_NAME: QUEEN'S MEDICAL CENTER

ORG_STATE: HI

PHR: Project Narrative Our project will create a “Hawai‘i Health Equity Research and Outreach Network (HAWAI‘I HERON)” that will provide resources to support efforts to improve health equity for Asian American, Native Hawaiian and other Pacific Islander (AA-NHPI) populations. This work will be in collaboration with the Food and Drug Administration and other minority-serving institutions and will include a pilot study examining AA-NHPI patient preferences for diabetes medications. HAWAI‘I HERON has the potential to strengthen health equity focused research, outreach and communications, and training and mentoring of diverse students and junior researchers.

PI_NAMEs: SETO, TODD B (contact);TAIRA, DEBORAH ANN

PROGRAM_OFFICER_NAME: LEE, CHRISTINE


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: PORTLAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Lack of robust remyelination represents a major barrier in the recovery of neurological function in disease or after injury in many nervous system disorders. Here, we propose to determine how the atypical GEF Dock1 controls myelin development and repair. These studies can lay the foundation to help define new strategies to stimulate remyelination in the injured and diseased nervous system.

PI_NAMEs: MONK, KELLY R (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Action Potentials;Adult;Axon;axon regeneration;axonal degeneration;Biological;Cell Communication;cell type;Cells;Cellular biology;Cellular Morphology;Cytokinesis;Cytoskeleton;Data;Dedications;Defect;Demyelinations;Development;Disease;Docking;ERBB2 gene;Exhibits;experimental study;Foundations;Genetic;genetic approach;Genetic Screening;glial cell development;Guanine Nucleotide Exchange Factors;Health;Human;Impairment;in vivo imaging;injured;Injury;insight;Link;Lipids;Maintenance;Mammals;Membrane;migration;Molecular;Morbidity - disease rate;mouse model;Multiple Sclerosis;mutant;Mutant Strains Mice;Mutation;Myelin;Myelin Sheath;myelination;Natural regeneration;nerve injury;nerve repair;Nervous System;nervous system development;Nervous System Disorder;Nervous System Physiology;Neuroglia;neurological recovery;neuron loss;Neurons;Neuropathy;novel therapeutics;Pain;Paralysed;Pathway interactions;peripheral nerve damage;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Phagocytosis;pharmacologic;Phenotype;Play;prevent;Process;Radial;Receptor Protein-Tyrosine Kinases;remyelination;repaired;Resolution;rho GTP-Binding Proteins;Role;Schwann Cells;Signal Pathway;Signal Transduction;Sorting;Testing;Visualization;Work;Zebrafish

PROJECT_TITLE: Mechanisms of Axon-Schwann cell interactions


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative In a recent large scale of genome-wide analysis study, a rare coding variant was identified in Abelson interactor family member 3 (ABI3) gene and this variant is associated with increased risk of late-onset Alzheimer's disease. The overarching goal of this application is to understand the role of ABI3 in microglia and the mechanisms by which ABI3 affects in the context of AD. This can lead to identifying the key regulators of the mechanism and subsequently determination of the new therapeutic targets in AD.

PI_NAMEs: KIM, JUNGSU  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: abeta accumulation;Abeta clearance;Actins;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Amyloidosis;Biochemical;Brain;Brain imaging;Brain region;cancer cell;Cell Culture Techniques;Cell Physiology;Cells;Cellular Assay;Coculture Techniques;Code;complement system;Complex;CRISPR/Cas technology;cytokine;Cytokinesis;Cytoskeletal Modeling;Disease;druggable target;effective therapy;Electrophysiology (science);Endocytosis;Etiology;experimental study;Family member;Gene Expression;Genes;genetic approach;genetic risk factor;Genetic study;genome editing;genome-wide;genome-wide analysis;Gliosis;Goals;Hippocampus;Human;Human Genetics;human induced pluripotent stem cells;Immune response;Immunity;immunoreactivity;Impairment;In Vitro;Inflammatory;innovative technologies;insight;interest;knock-down;Knock-in Mouse;Knock-out;Knowledge;Late Onset Alzheimer Disease;Magnetic Resonance Imaging;Manuscripts;Mass Spectrum Analysis;Mediating;Microglia;migration;Modeling;mouse model;Mus;Nature;Neurons;neuropathology;Neurosciences;new therapeutic target;novel;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phagocytosis;Pharmacology;Phenotype;Play;Positron-Emission Tomography;Proteome;Proteomics;Reporting;Risk;risk variant;RNA Interference;Role;Senile Plaques;single-cell RNA sequencing;superresolution microscopy;Synapses;synaptic function;System;Systems Biology;Testing;transcriptome;transcriptomics;uptake;Variant;Wild Type Mouse;β-amyloid burden

PROJECT_TITLE: The role of ABI3 in Alzheimers disease


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Microbiome;Nutrition;Pediatric;Prevention

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE: Food allergies are on the rise, and yet the care of food allergic patients is limited by the lack of accurate biomarkers of disease development and resolution, as well as by the absence of curative treatments. The goal of this project is to investigate the role of RELMb as a novel candidate biomarker of food allergy and to elucidate the mechanisms by which it contributes to food allergy pathogenesis. This research will address an existing gap in the knowledge of food allergy mechanisms and improve the daily management of patients with food allergies.

PI_NAMEs: CRESTANI, ELENA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Affect;Age;Allergens;Allergic;Allergic Disease;allergic response;Anaphylaxis;Asthma;Atopic Dermatitis;Award;Biological Markers;biomarker development;biomarker discovery;Biometry;candidate marker;career;career development;Caring;Cells;Child;Childhood;Clinical;clinical application;Clinical effectiveness;clinical investigation;cohort;Communities;curative treatments;Data Analyses;Development;Diagnosis;Disease;Disease Outcome;enteric pathogen;Environment;Environmental Risk Factor;Epidemic;Epidemiology;Equilibrium;Evaluation;Five-Year Plans;Food;Food Hypersensitivity;food protection;Foundations;Frequencies;Funding;Future;GATA3 gene;Generations;Genetic;Goals;gut microbiome;Head;Health;Human;IgE;Immune;Impairment;improved;Individual;Institution;Interleukin-4;Investigation;Knowledge;Laboratories;Learning;Life;Life Style;mast cell;Master of Public Health;Mediating;Mentors;metabolomics;microbial composition;microbiome;microbiome composition;Modernization;Molecular;mouse allergy;mouse model;Mucous Membrane;Mus;novel;novel marker;novel therapeutic intervention;oral tolerance;Pathogenesis;Pathogenicity;Patients;Physicians;Plasma;Play;Positioning Attribute;Prevalence;Production;Public Health;Public Health Schools;Quality of life;Regulation;Regulatory T-Lymphocyte;Research;Research Personnel;resistin;Resolution;Resources;response;Risk;Role;Scientist;Serum;Severities;Signal Transduction;skills;symposium;T cell response;targeted treatment;Techniques;Testing;Therapeutic Intervention;Time;Training;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: Function of RELMβ in oral tolerance breakdown in food allergy

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative The research training and academic preparation of underrepresented undergraduates is critical to ensure that a diverse and highly trained workforce is available to assume leadership roles in the Nation’s biomedical research enterprise, to address the need of improving the health of the people of the United States. This project provides extraordinary opportunities for undergraduates from underrepresented groups to be trained as the next generation of leaders in biomedical research.

PI_NAMEs: DE LA CRUZ, MARLENE ;MOTA-BRAVO, LUIS M (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Academic advising;Biological Sciences;Biomedical Research;California;career;CCL7 gene;Communication;Computational Biology;Critical Thinking;design;Doctor of Philosophy;Doctor's Degree;Educational Curriculum;Educational workshop;Elements;Environment;experience;Extramural Activities;Faculty;faculty mentor;Faculty Workshop;Funding;Genomics;graduate school;improved;Individual;Institution;interest;Journals;Knowledge;Literature;Methods;Minority;Oral;Participant;posters;Preparation;Process;programs;Readiness;Reading;Reproducibility;Research;research faculty;Research Training;responsible research conduct;Schools;Science;Scientist;Series;Site;skills;statistics;Students;symposium;Training;undergraduate student;Universities

PROJECT_TITLE: MARC at the University of California, Irvine

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Breast Cancer;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Pain Research;Rehabilitation;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Aromatase inhibitors (AIs) reduce cancer recurrence and improve survival in breast cancer survivors who are postmenopausal and have hormone-receptor positive (HR+) tumors, but they also cause painful arthralgia that is distressing, reduces health-related quality of life, and contributes to poor AI adherence. Pain coping skills training—an evidence-based cognitive-behavioral pain intervention—could address these problems, especially if delivered as an automated, web-based program that overcomes current barriers to accessing it. Expanding access to an evidence-based behavioral pain intervention that is low cost and highly scalable is consistent with guidelines for managing pain in cancer and would be a step towards addressing symptoms limiting health and well-being in breast cancer survivors on AI therapy.

PI_NAMEs: RINI, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Address;Adherence;Adverse effects;Affect;Aftercare;Algorithms;Aromatase Inhibitors;Arthralgia;Behavior Therapy;Behavioral;Breast Cancer survivor;cancer pain;cancer recurrence;Caring;Cessation of life;chronic musculoskeletal pain;Clinical;clinical care;Cognitive;cognitive reappraisal;Cognitive Therapy;Communities;contactin;Contralateral Breast;Coping Skills;cost;Databases;Degenerative polyarthritis;design;disability;Distress;Educational process of instructing;emotional distress;evidence base;Exercise;experience;Feedback;Future;Geographic Locations;Guidelines;Health;health related quality of life;hormone receptor-positive;Hot flushes;improved;inhibitor therapy;innovation;Internet;Intervention;Interview;joint stiffness;Knee Osteoarthritis;knee pain;Knowledge;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Medical;Methods;Minority;Night Sweating;non-drug;novel;novel strategies;Online Systems;Pain;pain catastrophizing;Pain interference;Pain management;pain reduction;Participant;Patient Self-Report;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;Physical Function;post intervention;Postmenopause;primary endpoint;primary outcome;programs;Randomized;Randomized, Controlled Trials;Relaxation;Reporting;Research;Resources;Risk Reduction;rural area;secondary outcome;Self Efficacy;Severities;side effect;Site;skills;skills training;Sleep;Sleep Disorders;Sleep disturbances;Structure;Survivors;symposium;Symptoms;Telephone;Testing;Therapeutic;therapy development;therapy duration;Toxic effect;Training;Training Programs;Travel;treatment as usual;tumor;vasomotor symptoms;Woman

PROJECT_TITLE: Web-based Pain Coping Skills Training to Improve Pain and Poor Adherence caused by Aromatase Inhibitor-Associated Arthralgia In Breast Cancer Survivors (SKIP-Arthralgia): A Randomized Controlled Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-P(02)]


NIH_SPENDING_CATS: Cancer

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative/Relevance  This research is relevant to public health because it addresses the basic molecular mechanisms of how cells signal and how this signaling is deregulated in disease. Specifically, we focus on understanding the mechanisms of and enzyme that generally suppresses tumors, protein kinase C, and its negative regulator, the phosphatase PHLPP. This understanding will allow us to develop effective therapies to restore normal activity.

PI_NAMEs: NEWTON, ALEXANDRA C. (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Automobile Driving;Carcinogens;Cell Survival;comparative;Disease;effective therapy;Enzymes;Family;Isoenzymes;Knowledge;leucine-rich repeat protein;Malignant Neoplasms;Molecular;Oncogenes;Oncogenic;PH Domain;Phorbol Esters;Phosphoric Monoester Hydrolases;Phosphotransferases;protein activation;Protein Dephosphorylation;Protein Kinase C;Protein phosphatase;Public Health;receptor;Regulation;Research;Role;Signal Pathway;Signal Transduction;Site;Structure;therapeutic target;tumor;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;Vision

PROJECT_TITLE: Molecular Mechanisms of Cell Signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Cutaneous lupus lesions are disfiguring, difficult to treat, and often associated with flares of systemic lupus that lead to organ damage and disability. This project will uncover novel mechanisms that regulate the pathologic features of lupus skin and will ultimately lead to new preventative and therapeutic strategies for this devastating disease. Discoveries made through this research are directly relevant to the NIH's mission to foster fundamental discoveries and their applications to protect and improve public health.

PI_NAMEs: KAHLENBERG, JOANNE MICHELLE (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Address;Apical;Apoptosis;Apoptotic;Automobile Driving;barrier to care;Behavior;Biology;CASP3 gene;CASP8 gene;Cells;Characteristics;chemokine;Chromatin;Chronic;Cutaneous Lupus Erythematosus;cytokine;Data;disability;Disease;Exhibits;Flare;Fostering;FOXO1A gene;FOXO3A gene;Functional disorder;Genetic;Genetic Transcription;Goals;improved;in vivo;in vivo Model;Inflammation;inflammatory modulation;Inflammatory Response;inhibitor;Interferon Type I;Interferons;IRF3 gene;keratinocyte;kinase inhibitor;Knowledge;LATS1 gene;Lesion;Literature;Lupus;lupus cutaneous;Malignant Neoplasms;Mediating;Mediator;member;Mission;novel;novel therapeutics;Nucleic Acids;Organ;overexpression;Pathogenicity;Pathologic;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;Photosensitivity;prevent;Prevention;Production;Proteins;Public Health;Reporting;Research;response;Risk;Role;Secondary to;side effect;Signal Pathway;Signal Transduction;Skin;skin disorder;Stimulator of Interferon Genes;synergism;Systemic Lupus Erythematosus;TBK1 gene;Therapeutic;TRAF6 gene;Ubiquitination;Ultraviolet B Radiation;United States National Institutes of Health;Up-Regulation;Virus Diseases;Work

PROJECT_TITLE: Hippo signaling as a critical regulator of lupus keratinocyte dysfunction


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The use of technology to deliver health care and manage chronic and critical illness is becoming increasingly pervasive. The overarching goal of this T32 (Technology Research in Chronic and Critical Illness) is to provide rigorous research training and interdisciplinary professional socialization to build nursing science aimed at promoting health, managing illness, reducing disability and enhancing quality of life through the aid of technology and clinical data science. This program will enable nurse trainees to be well-positioned to conduct innovative, state-of-the-art research in this growing field based on principles of design-justice.

PI_NAMEs: LEE, YOUNG JI  (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TITLE: Technology Research in Chronic & Critical Illness


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Nonalcoholic fatty liver disease (NAFLD), which worsens cardiovascular disease and commonly causes cirrhosis, is the most prevalent cause of liver dysfunction in Western countries. The studies performed herein will be the first to reveal the importance of hepatocyte ketogenesis in regulating the most predictive index of poor prognosis in NAFLD pathogenesis, fibrosis. These studies will quantify how ketogenesis feeds back to regulate mitochondrial oxidative function in the liver, determine how ketone metabolism becomes dysregulated in NAFLD, and provide new potential intervenable metabolic nodes within distinct liver cell compartments to prevent NAFLD complications.

PI_NAMEs: CRAWFORD, PETER A (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Acceleration;Acetoacetates;Acinus organ component;adverse outcome;amino acid metabolism;Back;beta-Hydroxybutyrate;Bioenergetics;blind;Carbohydrates;Carbon;Cardiovascular Diseases;Cell Compartmentation;Cells;Chemicals;Cirrhosis;Citric Acid Cycle;Coenzyme A-Transferases;Compensation;Country;diabetes pathogenesis;Drug Targeting;Electrons;Energy Supply;Equilibrium;Exhibits;experimental study;Fatty acid glycerol esters;fatty liver disease;Feedback;feeding;Feeds;fibrogenesis;Fibrosis;Funding;Genetic;Geography;Health;Hepatic;Hepatic Fibrogenesis;Hepatocyte;High Fat Diet;Homeostasis;Human;Hydroxybutyrates;indexing;Injury;Insulin Resistance;Intervention Studies;intrahepatic;Investigation;Isotopes;ketogenesis;ketogentic;Ketone Bodies;Ketones;Knock-out;Knowledge;Kupffer Cells;Lipids;Liver;Liver diseases;Liver Dysfunction;Liver Fibrosis;liver function;liver injury;Liver Mitochondria;liver transplantation;Macrophage;Malignant neoplasm of liver;Mass Spectrum Analysis;Measurement;Measures;Metabolic;Metabolism;metabolomics;Mitochondria;mitochondrial oxidative dysfunction;Mus;Myeloid Cells;NADH;Nicotinamide adenine dinucleotide;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Nuclear Magnetic Resonance;Observational Study;oxidation;Oxidation-Reduction;Oxidoreductase;Oxygen;Pathogenesis;Pathogenicity;Phylogeny;preservation;prevent;Production;Prognosis;Protons;Proxy;Public Health;Publishing;Reporting;respiratory;Risk;Role;Severities;Signal Transduction;succinyl-coenzyme A;Testing;therapeutic target;Tracer;Transferase;Triglycerides

PROJECT_TITLE: Ketone Body Metabolism and Integrated Metabolic Homeostasis

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]