NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Homelessness;Infectious Diseases;Mental Health;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative When people lack the means to consistently meet their material needs for food, housing, finances, and healthcare, their health suffers, particularly for those already managing chronic diseases such as HIV or diabetes. The proposed study brings together a multidisciplinary team of experts for a five-year study among over 3000 men and women living with or at risk for HIV to understand how these unmet material needs work together to harm HIV and cardiovascular disease health. The ultimate goal is to reduce HIV and cardiovascular disease disparities, consistent with both the goals of National HIV/AIDS Strategy and with the nutritional, health behavior, CVD, and health disparities goals of US Healthy People 2020.

PI_NAMEs: FRONGILLO, EDWARD A;TURAN, BULENT ;WEISER, SHERI DAWN (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: acute care;Address;Affect;Blood;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;CD4 Lymphocyte Count;Characteristics;Chronic;Chronic Disease;Clinic Visits;Cohort Studies;Collection;Communities;cost effective;Data;design;Diabetes Mellitus;Disease;disease disparity;Disease Outcome;Disease Progression;disparity reduction;Dyslipidemias;Echocardiography;effective intervention;Enrollment;Epidemic;experience;Food;food insecurity;Functional disorder;Future;Goals;Health;Health behavior;health care availability;Health Care Costs;health disparity;Health Insurance;Healthcare;Healthy People 2020;Heart Diseases;HIV;HIV/AIDS;Homelessness;Housing;Hunger;Hypertension;Immunologics;improved;Individual;Inflammation;Investments;Joints;Laboratories;Left;Longitudinal Studies;low socioeconomic status;Measures;Mediating;medication nonadherence;meetings;men;Mental Depression;Mental Health;Methods;Morbidity - disease rate;mortality;multi-component intervention;multidisciplinary;nutrition;Nutritional;Outcome;Participant;Persons;Physical activity;Physiological;Physiological Processes;poor health outcome;Population;Populations at Risk;Poverty;prevent;primary outcome;Research;Research Methodology;resilience;Resources;Risk;Risk Factors;RNA;Running;secondary outcome;Site;social;social stigma;Social support;Stress;Surveys;tertiary care;Testing;Uncertainty;Unhealthy Diet;Uninsured;Ventricular;Woman;Women's Interagency HIV Study;Work

PROJECT_TITLE: Intersection of Material-Need Insecurities and HIV and Cardiovascular Health

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Rare Diseases

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Narrative This project will investigate the roles of DNA-damaging transposons during tumorigenesis, including their contributions to the progression of Barrett's esophagus to esophageal cancer. Using in vitro experimental systems and new approaches to genomic analyses in human tissues, we will determine the full scope of DNA rearrangements attributable to transposon activity.

PI_NAMEs: BURNS, KATHLEEN H (contact);LEE, EUNJUNG ALICE;ZHANG, CHENG-ZHONG

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: analytical method;Barrett Esophagus;Bioinformatics;Biological;Burn injury;cancer cell;cancer genome;cancer prevention;cancer type;Cells;Cellular biology;Chromosomal Instability;Chromosomes;Clonal Expansion;Colon Carcinoma;Complementary DNA;Computer Analysis;Data;Data Set;Dependence;Detection;Development;Dicentric chromosome;DNA;DNA copy number;DNA Damage;DNA Repair;DNA Sequence Rearrangement;DNA sequencing;DNA Transposable Elements;Elements;endonuclease;Esophageal Adenocarcinoma;Event;Evolution;Experimental Models;experimental study;Gene Rearrangement;Genes;Genetic Screening;Genetic study;Genetic Transcription;Genetic Variation;Genome;genome analysis;genome integrity;genome sequencing;genomic data;Genomic Instability;Genomics;High Prevalence;Human;human disease;Human Genetics;human tissue;In Vitro;in vitro Model;Insertion Mutation;insight;Joints;Knowledge;Laboratories;Lesion;live cell imaging;Long Interspersed Elements;Malignant - descriptor;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;Mediating;metaplastic cell transformation;Methods;Methylation;Modeling;Molecular;Molecular Biology;Monitor;Mutation;novel strategies;Open Reading Frames;Outcome;overexpression;Pathology;Population;premalignant;Prevalence;Process;promoter;Proteins;replication stress;Research Personnel;Resolution;Retrotransposition;Retrotransposon;Reverse Transcription;RNA;RNA-Binding Proteins;RNA-Directed DNA Polymerase;Role;S phase;Shotguns;Somatic Mutation;Source;System;Testing;The Cancer Genome Atlas;Therapeutic;Tissues;tumor;tumorigenesis;whole genome;Work

PROJECT_TITLE: Consequences of retrotransposition on genome integrity

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: RIVERSIDE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Histone Chaperones are emerging as regulators of cell fate decisions given their pivotal role in genome organization during DNA templated processes such as DNA replication and transcription. The goal of this research proposal is to understand the molecular mechanisms underlying the lineage specifying functions of histones chaperones. If successful, our work will be a stepping stone to developing new therapies and technologies where histone chaperone pathways can be manipulated to control cell fate.

PI_NAMEs: CHELOUFI, SIHEM  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Binding;Biochemical;Cell Fate Control;Cell Proliferation;Cell Reprogramming;Cells;Chromatin;chromatin assembly factor I;Complex;design;Development;Differentiated Gene;Disease;DNA;DNA biosynthesis;Elements;Enhancers;epigenome;gene repression;Genes;Genetic Recombination;Genetic Transcription;Genome;Goals;Health;Heterochromatin;Histones;Link;Maintenance;Molecular;Molecular Chaperones;multiple omics;new technology;novel therapeutics;Nucleosomes;Pathway interactions;Play;prevent;Process;promoter;Proteins;Regulation;repaired;Research;Research Proposals;RNA Interference;Role;Site;Specific qualifier value;stem;stem cells;structural determinants;Structure-Activity Relationship;transcription factor;Variant;Work

PROJECT_TITLE: Investigating the Regulatory Roles of Histone Chaperones in Cellular Plasticity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(55)R]


NIH_SPENDING_CATS: Bioengineering;Cancer

ORG_CITY: RICHLAND

ORG_NAME: BATTELLE PACIFIC NORTHWEST LABORATORIES

ORG_STATE: WA

PHR: PROJECT NARRATIVE Structures for Lossless Ion Manipulations (SLIM) will be developed to enable biomacromolecule separations and coupled to a TOF-MS to perform high resolution IMS/MS of macrobiomolecules, selective rerouting of a portion of the ion mobility spectrum for soft-landing (to deposition substrates) and characterize the soft-landed species using orthogonal characterization techniques (e.g., cryoEM).

PI_NAMEs: GARIMELLA, SANDILYA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TITLE: HIGHLY SELECTIVE MACROBIOMOLECULAR ISOLATION, SOFT-LANDING AND CHARACTERIZATION USING STRUCTURES FOR LOSSLESS ION MANIPULATIONS

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Lung;Patient Safety;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Chronic nontuberculous mycobacterial (NTM) pulmonary disease is an increasingly common orphan disease that causes progressive disability in older adults. Patient-reported outcome (PRO) measures are a patient- centered way to measure symptoms, functioning, and symptomatic adverse events over time. We seek to understand the trajectory of symptoms and their association with NTM pulmonary disease activity, response, and recurrence after treatment completion.

PI_NAMEs: HENKLE, EMILY M. (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acid Fast Bacillae Staining Method;Adult;Adverse event;Affect;Aftercare;Age;Airway Disease;American;Antibiotic Therapy;Antibiotics;Bacillus;Belief;biobank;Biological;Bronchiectasis;Caring;Characteristics;Chest;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinical;clinical care;Clinical Data;clinical outcome measures;clinical practice;Clinical Trials;Clinical Trials Network;cohort;Collaborations;Common Terminology Criteria for Adverse Events;Communicable Diseases;Coughing;Data;data repository;Diagnosis;disability;Disease;disease natural history;Disease Outcome;Electronics;Enrollment;Evaluation;experience;Fatigue;Frequencies;Friends;Fright;Future;health related quality of life;improved;Incidence;Inflammatory;interest;Intervention;Judgment;Knowledge;Left;longitudinal analysis;Longitudinal cohort;Lung;Lung Diseases;Measures;meetings;Mental Health;Monitor;Mycobacterium abscessus;Mycobacterium avium Complex;non-tuberculosis mycobacteria;novel;older adult;older patient;Outcome;Outcome Measure;Outcomes Research;pathogen;Patient Monitoring;patient oriented;Patient Outcomes Assessments;Patient Preferences;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Pharmacotherapy;primary outcome;Prospective cohort;Prospective, cohort study;Quality of life;radiological imaging;Rare Diseases;Recurrence;Regimen;Reporting;Research;respiratory;Respiratory Signs and Symptoms;response;Risk;Role;Shortness of Breath;Site;Societies;Soil;Sputum;Standardization;success;Symptoms;Testing;Time;tool;Toxic effect;treatment comparison;treatment response;Tuberculosis;United States Food and Drug Administration;Water

PROJECT_TITLE: Patient reported outcomes in patients with nontuberculous mycobacterial pulmonary disease

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Congenital malformations, or structural birth defects, are now the leading cause of infant mortality in the US. Of the congenital malformations, congenital heart disease (CHD) is the most common. We have recently developed genetic and biochemical platforms that will enable a systems based approach to uncover the essential protein and protein complexes that in mammalian heart development and in parallel, a patient driven approach to understanding the function of these proteins in human homeostasis and disease.

PI_NAMEs: CONLON, FRANK LEO (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Address;Adult;Architecture;Atrial Heart Septal Defects;Binding;Binding Sites;Biochemical;Bioinformatics;Biological Assay;Cardiac;Cardiac Myocytes;cardiogenesis;Catalytic Domain;Cell Nucleus;cell type;CHD4 gene;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complex;Congenital Abnormality;congenital heart abnormality;Deacetylase;Defect;Disease;DNA Binding;Embryo;GATA4 gene;Gene Expression;Gene Expression Profiling;gene repression;Genes;Genetic;Genetic Transcription;genomic locus;Goals;Health;Heart;Heart Diseases;heart function;histone methyltransferase;Homeostasis;Human;improved;improved outcome;in vivo;Infant Mortality;insight;Lead;Mass Spectrum Analysis;member;Missense Mutation;Modeling;mouse model;Mus;Muscle;mutant;Mutant Strains Mice;Mutation;Nature;Nucleosomes;null mutation;Pathway interactions;Patients;Phenotype;proband;protein complex;protein function;Proteins;Reagent;recruit;Repression;Role;Structural Congenital Anomalies;structural heart disease;System;Testing;Tissues;transcription factor;Transcription Repressor;Transcriptional Activation;transcriptomics;Ventricular;ventricular hypertrophy;Ventricular Septal Defects

PROJECT_TITLE: Mechanism and Function of Cardiac Transcriptional Repression Networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-K(02)]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Suicide

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Suicide is the second-leading cause of death in adolescence, yet its neurobiology is poorly understood, and there is a desperate need for improved methods to treat youth with suicidal behavior. This project will study negative urgency, a type of impulsivity occurring in the context of negative emotions that has been associated with suicidal behavior, and how it relates to impairment in inhibitory brain physiology using a noninvasive technique (transcranial magnetic stimulation paired with electroencephalography) in youth with suicidal thoughts and behaviors. A comprehensive training plan and multidisciplinary mentoring team will ensure high productivity during the award period and the candidate’s successful transition to a career as an independent clinical investigator of adolescent suicidal behavior.

PI_NAMEs: LEWIS, CHARLES P. (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Development;Age;Attention;Award;Behavior;Behavioral;Behavioral Mechanisms;Benchmarking;Brain;brain behavior;career;career development;Cause of Death;child depression;Clinical;clinical application;Clinical Investigator;Clinical Research;Cognitive;Collaborations;Data;Depressed mood;design;Development;Development Plans;Electroencephalography;Electromyography;emotion regulation;Emotional;Emotions;Ensure;Exanthema;experience;Extramural Activities;Feeling suicidal;follow-up;Future;GABA Receptor;Goals;Grant;high risk;Impairment;improved;Impulsive Behavior;Impulsivity;indexing;Interneurons;Interruption;Intervention;Intervention Studies;Interview;Investigational Therapies;Knowledge;Link;Longitudinal Studies;Measures;Mediating;Mentors;Mentorship;Methodology;Methods;Motor;Motor Cortex;multidisciplinary;multimodality;neural;neural network;neurobehavioral;Neurobiology;neuromechanism;neurophysiology;neuroregulation;novel;Participant;Patient Self-Report;Physiology;Positioning Attribute;Prefrontal Cortex;Prevention strategy;preventive intervention;Process;Productivity;Public Health;Publications;Research;Research Methodology;Research Personnel;Risk Factors;Role;skills;Structure;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Symptoms;System;Techniques;Testing;Time;Training;Transcranial magnetic stimulation;Translating;Translations;Work;Youth

PROJECT_TITLE: Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Greater exposure to stressful situations, coupled with limited access to the financial and social resources needed to manage stress in healthy ways are believed to contribute to persistent racial/ethnic disparities in Alzheimer's disease and related dementias (ADRD). Our study combines personalized and objective indicators of the body's response to stressful experiences with multi-modal neuroimaging and longitudinal cognitive assessments in a unique multi-ethnic cohort. Our findings will inform stress management interventions and precision medicine initiatives designed to prevent ADRD and/or slow its progression

PI_NAMEs: KERSHAW, KIARRI N (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: abeta deposition;Abeta synthesis;Acute;adjudication;Adult;Affective;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Animals;arterial stiffness;Atherosclerosis;Attention;biological adaptation to stress;Biological Markers;Blood Pressure;Blood Vessels;Brain;Cerebrovascular Circulation;Chronic;Cognitive;cognitive function;cognitive testing;cohort;Communities;coping;Coupled;Data;dementia risk;design;Disparity;Electrocardiogram;Emotions;Episodic memory;ethnic disparity;ethnic minority;executive function;experience;experimental study;Exposure to;Face;follow-up;Gene Expression;Genetic Transcription;Glucocorticoids;Goals;gray matter;Heart Rate;heart rate variability;high risk;Human;hydrocortisone receptor;Hypothalamic structure;Impaired cognition;Impairment;Incidence;Individual;Intervention;Laboratories;Life;Link;Literature;low socioeconomic status;Measurement;Measures;memory process;Minority;molecular marker;Monitor;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;multimodal neuroimaging;negative affect;Nerve Degeneration;neuroimaging marker;Participant;Pathology;Pathway interactions;Physiological;Pituitary Gland;Precision Medicine Initiative;Prevalence;prevent;Psychosocial Factor;racial disparity;racial minority;Recommendation;Reporting;Research;Resources;response;Risk;Severities;social;Stress;stress management;stress reactivity;Stressful Event;stressor;Surveys;Sympathetic Nervous System;symposium;System;Telephone;Testing;vascular cognitive impairment and dementia;Vascular Dementia;White Matter Hyperintensity

PROJECT_TITLE: Contributions of stress reactivity to risk of Alzheimer's disease and related dementia's in a community-based cohort

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: FORT COLLINS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Substance use rates among American Indian adolescents have been greater than national rates for decades, and recent evidence indicates that some substance use disparities are increasing for American Indian adolescents living on or near reservations (hereafter reservation). This proposed study will continue to monitor rates of use for reservation American Indian adolescents and compare these rates to national rates, in addition to estimating relationships between substance use and measures of strength and resilience especially pertinent to this population. The findings from this study will be disseminated to key stakeholders including participating schools and local and national Native groups and organizations, and will inform prevention, intervention, and policy efforts designed to reduce substance use among this population.

PI_NAMEs: PRINCE, MARK A;STANLEY, LINDA RAE (contact);SWAIM, RANDALL C

PROGRAM_OFFICER_NAME: LOPEZ, MARSHA

PROJECT_TERMS: Address;Adolescent;adolescent substance use;Affect;Alcohol consumption;Alcohols;American Indians;Area;base;Behavior;Characteristics;Cocaine;Communities;Community Health;community-level factor;Consumption;Data;design;Development;Disparity;Economics;effective intervention;epidemiological model;Epidemiology;epidemiology study;ethnic identity;Ethnic Origin;Etiology;experience;Frequencies;Future;Geography;Hallucinogens;Health;high risk;Indian reservation;Individual;Inequity;Intervention;Intervention Studies;Life;Literature;Marijuana;marijuana use;Measures;Methamphetamine;Methods;Modeling;Monitor;multilevel analysis;Native Americans;Native-Born;Nature;Opioid;Outcome;outcome disparities;Pathway interactions;Pattern;Pharmaceutical Preparations;Policies;Population;Prevalence;Prevention;Property;protective factors;Psychometrics;Public Health;Race;Reduce health disparities;reduced substance use;Research;Research Personnel;Reservations;resilience;Resource Allocation;Resources;Risk;Risk Factors;Role;Sampling;Schools;sex;sixth grade;Societies;socioeconomics;Source;Students;substance use;theories;trend;Tribes;Work;Youth

PROJECT_TITLE: Substance Use Among American Indian Youth: Epidemiology & Etiology

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Infertility;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative/Public Health Relevance Statement Aberrant DNA methylation in gametes is associated with idiopathic infertility, poorer outcomes during fertility treatment, ovarian aging, and can be deleterious to embryonic development. In this proposal, I seek to elucidate the intracellular and extracellular cues that instruct the patterning of DNA methylation in oocytes and sperm. This study will further our understanding of how de novo epimutations that adversely impact fertility and development may arise.

PI_NAMEs: PRASASYA, REXXI DIPTYA (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Aberrant DNA Methylation;Advisory Committees;Age;Binding;Biochemical;Bioinformatics;bisulfite sequencing;candidate identification;Cell Reprogramming;Cells;Cleavage Under Targets and Release Using Nuclease;Coupled;Cues;demethylation;Deposition;Development;Dioxygenases;DNA;DNA Methylation;DNA Modification Methylases;Embryo;Embryonic Development;Environment;Enzymes;Epiblast;Epigenetic Process;epigenome;epigenomics;Event;Exclusion;Exhibits;experimental study;extracellular;Female;Fertility;Fertilization;follow-up;Gametogenesis;Genetic;Genetic Diseases;Genetic Models;Genome;Genomic Imprinting;genotypic sex;Germ Cells;Germ Lines;Gonadal structure;granulosa cell;Growth;Histones;Human Genetics;Hypermethylation;idiopathic infertility;in vivo;infertility treatment;Knowledge;Length;male;Mentors;Mentorship;Methylation;methylation pattern;methylome;Methyltransferase;Modeling;Modification;Molecular;mouse model;multiple omics;Mus;mutant;Mutation;Nature;novel;offspring;Oocytes;Outcome;Ovarian aging;overexpression;Parents;Pathway interactions;Pattern;Phase;Post-Translational Protein Processing;postnatal;prevent;Process;public health relevance;recruit;Reproduction;reproductive;Research Personnel;Resistance;Role;sertoli cell;sex;sexual dimorphism;Signal Pathway;Signal Transduction;single cell genomics;Site;Somatic Cell;Specific qualifier value;sperm cell;Spermatogonia;Structure of primordial sex cell;Supporting Cell;Testing;Time;Tissues;Training;transcription factor;transcriptomics;transdifferentiation;transmission process;whole genome;WNT Signaling Pathway

PROJECT_TITLE: Molecular determinants of sex-specific DNA methylation signature acquisition in the mammalian germline

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Organ Transplantation;Transplantation

ORG_CITY: GARRISON

ORG_NAME: HASTINGS CENTER, INC.

ORG_STATE: NY

PHR: PROJECT NARRATIVE Xenotransplantation (XTx) is a novel experimental treatment that involves transplanting organs from nonhuman animals into humans to reduce the organ shortage—a public health problem. Most guidance documents addressing the ethical and policy challenges for XTx are limited because they are 10-20 years old, do not reflect changes in the science of XTx, and do not account for stakeholder concerns. Our team of bioethicists and translational scientists will develop up-to-date ethics and policy recommendations and decision aids for transplant candidates, transplant clinicians preparing to conduct XTx clinical trials, and institutional review boards that will review XTx clinical trial protocols. Our proposed recommendations and decision aids will facilitate the ethical translation of XTx clinical trials to reduce the organ shortage.

PI_NAMEs: GORDON, ELISA J;GUSMANO, MICHAEL KELLEY;MASCHKE, KAREN JOANN (contact)

PROGRAM_OFFICER_NAME: COLLIER, ELAINE S

PROJECT_TERMS: 20 year old;Address;Advisory Committees;Affect;Animal Organ;Animals;beneficiary;Bioethics;Bioethics Consultants;Case Study;Clinical;clinical care;Clinical Research;clinical trial protocol;Clinical Trials;Communicable Diseases;Data Coordinating Center;Decision Aid;Decision Making;design;Development;disease transmission;disorder risk;Eligibility Determination;Endogenous Retroviruses;Enrollment;Ensure;Equity;Ethics;Evaluation;experimental study;Family suidae;first-in-human;Future;genetic technology;genome editing;Guidelines;Health;Heart;Human;Human Research Ethics;human subject;Human Subject Research;Immunosuppression;Informed Consent;innovation;Institution;Institutional Review Boards;Insurance Carriers;Interview;Islet Cell;Kidney;Kidney Transplantation;Liver;Medicine;member;Methods;nonhuman primate;novel;Organ;organ allocation;Organ Transplantation;Outcome;Pan Genus;Papio;patient oriented;Patient Participation;Patients;Perception;Persons;Policies;policy recommendation;pre-clinical research;Psychiatrist;Psychologist;Public Health;Recommendation;Renaissance;Reporting;Research;Research Ethics;Research Personnel;Risk;risk mitigation;safety testing;Science;Scientific Advances and Accomplishments;Scientist;Site;Skin;Solid;sound;Structure;success;Surgeon;Surveys;survival outcome;Survival Rate;Techniques;Testing;Translating;Translational Research;translational scientist;Translations;transmission process;transplant centers;Transplant Recipients;Transplantation;United States;Universities;Update;Waiting Lists;Xenograft procedure;Zoonoses

PROJECT_TITLE: Informing Ethical Translation of Xenotransplantation Clinical Trials


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Elevated rates of depression in college students is a very serious public health problem resulting in poor academic performance and psychosocial functioning, increased risk of dropping out of college, a greater likelihood of self-harm and suicide, and a chronic course of illness. The proposed project is designed to investigate the dynamic interplay between social stress, social safety schemas, inflammation, and depression symptoms in freshman transitioning to campus for the first time. Better understanding of how social stress and socially- oriented cognitive vulnerabilities affect biological processes underlying risk for depression is crucial to inform the prevention of this highly burdensome disorder.

PI_NAMEs: MORIARITY, DANIEL P (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Affect;Area;Award;Behavior;Biological;Biological Process;Biology;Blood;Blood specimen;Chronic;Clinical;Cognition;Cognitive;Cognitive Therapy;college;critical period;Dangerousness;Data;Data Collection;Data Reporting;depression model;depressive symptoms;design;Development;Diagnosis;Diagnostic;Disease;Drops;Electronic Mail;Equation;Etiology;Event;experience;follow-up;Fostering;Frequencies;Friends;Future;Goals;Health;high school;Immunologics;Immunology;Impairment;Individual;Individual Differences;Inflammation;Inflammatory;insight;Intervention;Interview;Laboratories;Learning;Life;life span;Life Stress;Link;Long-Term Depression;longitudinal design;Measurement;Measures;Mediating;Mediator;Medical;Mental Depression;Mental disorders;Mentors;Methods;Modeling;multilevel analysis;National Institute of Mental Health;Outcome;Participant;Pathway interactions;Patient Self-Report;perceived stress;Performance;Persons;Phase;Positioning Attribute;Prevention;Process;prospective;Proteins;Protocols documentation;psychologic;Psychopathology;psychosocial;Public Health;Quasi-experiment;recruit;Recurrence;Reporting;Research;Research Design;research faculty;Research Personnel;Risk;Risk Factors;risk mitigation;Role;Safety;School Drop-Outs;Self-Injurious Behavior;skills;social;Social Environment;social situation;social stress;social stressor;Specificity;statistics;Stress;stress symptom;Stressful Event;stressor;Student Dropouts;Students;Suicide;Suicide attempt;Symptoms;Technical Expertise;Testing;theories;Thinking;Time;Training;trait;university student;Work

PROJECT_TITLE: Testing a Social Safety Theory Perspective on Depression: An Intensive Longitudinal Immunopsychiatric Data Approach


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: IRVINE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Increased infectious disease outbreaks, highlighted by the current COVID-19 pandemic, serves as a constant reminder of the importance of diagnostics for infectious diseases and the large diagnostic gap in our response arsenal. Whispering Gallery Mode (WGM) devices that consist of microbubble resonators are a novel class of highly sensitive optical sensor with simple fluid handling. Through these studies, we will address this gap and leverage microbubble resonators for the rapid, multiplexed detection of viruses as a versatile biosensing platform both for laboratory and field deployment.

PI_NAMEs: QAVI, ABRAHAM JALEEL (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: 2019-nCoV;Address;Affinity;Africa;Africa South of the Sahara;analytical tool;antibody engineering;antibody mimetics;Area;Binding;Biochemistry;Biological Assay;Biophysics;Biosensing Techniques;Buffers;California;career;career development;Case Fatality Rates;Cessation of life;Chemistry;Clinical Pathology;Cold Chains;Communicable Diseases;Complex;Coupling;COVID-19 pandemic;Data;Democratic Republic of the Congo;design;Detection;detection method;Development;Development Plans;Devices;Diagnostic;diagnostic assay;diagnostic development;Disease;Disease Outbreaks;Doctor of Philosophy;Ebola;Ebola Hemorrhagic Fever;Ebola virus;Electronics;emerging pathogen;emerging virus;Engineering;Enrollment;Enzyme-Linked Immunosorbent Assay;Filovirus;follower of religion Jewish;Foundations;Glycoproteins;Goals;Hospitals;human pathogen;Illinois;Immune response;Immunology;Individual;Infection;International;Laboratories;Lasers;Lassa virus;Lead;Light;Liquid substance;manufacturing cost;Measurement;Medical;Mentors;Mentorship;Methods;Microbubbles;Molecular Biology;Monoclonal Antibodies;multiplex detection;nanoparticle;new outbreak;novel;novel diagnostics;optical sensor;Optics;Output;particle;pathogen;Pathogen detection;Pathogenicity;Pathology;Pathway interactions;Performance;Phase;photonics;physician-scientist training program;Physicians;Positioning Attribute;Process;professor;programs;Protein Biochemistry;Protein Engineering;rapid detection;Reagent;Reporter;Research;Research Personnel;Residencies;response;RNA Viruses;Sampling;Scholars Program;Scientist;sensor;sensor technology;Sentinel;Serology;Signal Transduction;Source;standard of care;System;Techniques;Testing;Time;Training;training opportunity;Universities;Validation;Vesicular stomatitis Indiana virus;Viral;viral detection;Viral Genome;Viral Hemorrhagic Fevers;Viral Markers;Viral Proteins;virology;Virus;Virus Diseases;Washington;Work

PROJECT_TITLE: Development of Optofluidic Resonators for Filoviral Detection


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Kidney Disease

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Chronic Kidney Disease is an extremely common medical problem. The consequences of chronic kidney disease include kidney failure requiring dialysis or a kidney transplant; cardiovascular disease and stroke; physical and cognitive disabilities; and premature death. The Chronic Renal Insufficiency Cohort (CRIC) Study is a long-term, observational study designed to evaluate factors that might be responsible for these adverse outcomes in adults with chronic kidney disease.

PI_NAMEs: APPEL, LAWRENCE JOHN (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Adult;adverse outcome;Affect;Ancillary Study;Arrhythmia;Biological;Cardiovascular Diseases;Cardiovascular system;Cessation of life;Chronic Kidney Failure;Chronic Kidney Insufficiency;Chronic Phase;Clinical;clinical center;cognitive disability;cohort;Cohort Studies;Collaborations;Communities;Data;Data Collection;Data Coordinating Center;data integration;Data Sources;design;Dialysis procedure;Disease Progression;Eligibility Determination;Enrollment;Ensure;Epidemiology;epidemiology study;ethnic diversity;Event;follow-up;Funding;Future;Goals;Grant;health data;Heterogeneity;Home;home test;Individual;innovation;Institution;Investigation;Kidney Diseases;Kidney Failure;Kidney Function Tests;Kidney Transplantation;Leadership;Link;Maryland;Measurement;Measures;Medical;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Observational epidemiology;Observational Study;Outcome;Parents;Participant;participant enrollment;Patient-Focused Outcomes;Phase;Phenotype;phenotypic data;physically handicapped;Physiological;Positioning Attribute;premature;Process;Productivity;programs;Progress Reports;Prospective cohort;Prospective Studies;Protocols documentation;Publications;racial diversity;recruit;renal damage;Renal function;repository;Research;Research Design;Research Personnel;Resources;response;Risk Factors;Role;social;Source;Stroke;success;tool;Translational Research;Universities;Visit

PROJECT_TITLE: Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Hopkins Clinical Center


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Genetic Testing;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE This project brings together a team of experts in genetics, genomics, and maternal fetal medicine to introduce whole-genome sequencing as a viable first-tier diagnostic test for fetuses with severe structural anomalies detected on ultrasound. Our team will leverage novel methods for prenatal genetic testing of fetal samples from amniocentesis and excess tissue from the most severe extremes of fetal developmental anomalies in humans. Our goal will be to characterize all classes of point mutations and structural variants, and support the introduction of routine genomic screening in fetal samples from both invasive and non-invasive procedures.

PI_NAMEs: TALKOWSKI, MICHAEL E (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Address;Adoption;aggregation database;algorithm development;Algorithms;Amniocentesis;analytical method;Area;Artificial Intelligence;autism spectrum disorder;Base Sequence;Bayesian Modeling;Benchmarking;case control;causal variant;cell free fetal DNA;Childhood;Clinical;clinical diagnostics;Code;cohort;Computing Methodologies;congenital anomaly;cost;Data;Data Aggregation;Data Set;de novo mutation;Development;Diagnosis;Diagnostic;Diagnostic tests;DNA analysis;DNA sequencing;dosage;Early Diagnosis;early screening;exome sequencing;Face;fetal;Fetus;First Pregnancy Trimester;Funding;gene discovery;Genes;Genetic;genetic testing;Genome;genome sequencing;Genomic medicine;Genomics;Gestational Age;Goals;Healthcare;high risk;Human;improved;in silico;innovation;insertion/deletion mutation;Joints;Karyotype;machine learning method;Maternal-fetal medicine;Methods;Modeling;Molecular Abnormality;Mutation;Natural Selections;Neonatal Mortality;next generation;Non-Invasive Detection;Normal Cell;novel;open source;Pathogenicity;Patients;Pattern;Phenotype;Point Mutation;Population;prenatal;Prenatal Diagnosis;prenatal testing;Procedures;Process;programs;Resolution;Resources;Sampling;screening;standard of care;Standardization;Structural defect;Technology;technology development;Testing;Tissues;tool;transmission process;ultrasound;Update;uptake;Validation;Variant;variant detection;Visualization;whole genome

PROJECT_TITLE: Clinical Diagnostic Sequencing of Structural Variation

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cardiovascular;Heart Disease;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_DEPT: SURGERY

PHR: Although the survival rate of breast cancer (BC) increases over the years, BC survivors remain at elevated risk of cardiovascular disease (CVD)-related morbidity and mortality. Our overarching goal is to develop solid computational and theoretical foundations for learning from imbalanced real-world data, with an emphasis on BC-CVD outcome risk prediction. The successful implementation of this project would lay a computational foundation for imbalanced data and can provide more accurate tools for predicting BC

PI_NAMEs: CUI, YING ;SUN, JU  (contact);ZHANG, RUI

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: Adoption;breast cancer diagnosis;Breast Cancer survivor;cancer prevention;Cardiotoxicity;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Characteristics;Chronic;Classification;Clinical;computer framework;Data;Development;Diagnosis;Disease Outcome;Electronic Health Record;electronic health record system;Event;evidence based guidelines;Foundations;General Population;Goals;Image;improved;Incidence;Individual;Learning;Malignant Breast Neoplasm;Morbidity - disease rate;mortality;multimodality;Patients;point of care;predictive tools;prevent;risk prediction;risk prediction model;Solid;Structure;success;Survival Rate;Time;Treatment Protocols

PROJECT_TITLE: SCH: A New Computational Framework for Learning from Imbalanced Biomedical Data


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

PHR: The continuation of this unparalleled combined adoption/twin study will contribute to a greater prospective understanding of the manner in which cognitive abilities, physical health, and neighborhood environments promote cognitive functioning at midlife. A fuller understanding of genetic and environmental influences, and how they interact with early life factors to affect midlife cognitive functioning, may contribute to improved cognitive health as well as to better health education and services.

PI_NAMEs: REYNOLDS, CHANDRA A (contact);WADSWORTH, SALLY J

PROJECT_TERMS: Accounting;Address;Adolescence;Adolescent;Adoption;Adult;Affect;Age;age acceleration;aging related;Alzheimer's Disease;Alzheimer's disease risk;behavior prediction;Behavioral;Biological Markers;Blood;Body mass index;Buffers;Child;Cognition;Cognitive;cognitive ability;Cognitive aging;cognitive change;cognitive function;cognitive performance;cognitive reserve;Colorado;contextual factors;cytokine;Data;Data Collection;Dementia;design;Development;Disadvantaged;DNA Methylation;Education;England;Environment;Environmental Risk Factor;epigenetic clock;Etiology;Exposure to;follow-up;Follow-Up Studies;Foundations;Genes;Genetic;Genetic Risk;genome-wide;Genotype;Health;Health behavior;Health education;Health Services;Heritability;Human Herpesvirus 4;Immune;improved;indexing;Individual;Individual Differences;infancy;Inflammatory;Life;life span;Life Style;Light;Maintenance;Measures;Mediating;Mediator;Methylation;microbial;middle age;Modeling;Neighborhoods;neurofilament;Neurotransmitters;Participant;Pathway interactions;Pattern;Performance;physical conditioning;Positioning Attribute;Predictive Factor;predictive marker;Prevention;proband;prospective;protective factors;resilience;resilience factor;Risk;Risk Factors;Siblings;Signal Transduction;Site;Sleep;sociodemographics;Speed;Stress;substance use;Testing;transcriptome;transmission process;Twin Multiple Birth;Twin Studies;Urbanicity;Wales;walkability;Work;young adult

PROJECT_TITLE: Colorado Adoption Project/Twin Study of Lifespan behavioral development & cognitive aging [CATSLife2]

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-K(02)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Neurosciences;Pediatric

ORG_CITY: AUSTIN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: NARRATIVE  Exposure to elevated manganese from environmental sources (e.g. drinking water or air) leads to severe motor deficits in infants, children and adolescents. This proposal will establish the mechanisms by which environmental manganese exposure in vulnerable early-life periods induces motor disease, which are not yet known, and further contribute to the development of a treatment for this condition.

PI_NAMEs: MUKHOPADHYAY, SOMSHUVRA  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Air;Basal Ganglia;Behavioral;Behavioral Assay;Biological Assay;Biology;Cells;Child;Childhood;Corpus striatum structure;Development;Disease;Dopamine;Dopamine Agonists;dopaminergic neuron;drinking water;Drug usage;Environmental Exposure;Exhibits;Exposure to;Functional disorder;Goals;Human;in vivo;infancy;Infant;innovation;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Life;Manganese;Manganism;Metals;Microdialysis;Microscopy;Modeling;Motor Activity;motor deficit;motor disorder;motor impairment;Motor Skills;mouse model;Movement;Mus;Nerve Degeneration;neurochemistry;Neuronal Dysfunction;Neurons;neurotoxicity;neurotransmission;novel;Occupational;Oral;Parkinson Disease;Parkinsonian Disorders;pharmacologic;Phenocopy;Phenotype;Population;Posture;Public Health;Role;Source;Substantia nigra structure;System;Testing;theories;Therapeutic;Time;Work

PROJECT_TITLE: Neuronal Targets and Mechanisms of Manganese Neurotoxicity

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE The hippocampus is the central brain structure without which we could not navigate our environment or remember recent events. The hippocampal synaptic circuits that mediate information transfer and contribute to the storage and retrieval of memories are therefore crucial to our understanding of memory deficits associated with aging and neurological disorders such as Alzheimer’s disease. In this project we will dissect the mechanisms that contribute to plasticity of a hippocampal synapse and determine how this contributes to specific forms of episodic memory.

PI_NAMEs: CONTRACTOR, ANIS  (contact);SAVAS, JEFFREY NICHOLAS

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: 2'-adenylic acid;Affect;Aging;Alzheimer's Disease;Anatomy;Animals;Anxiety Disorders;Behavioral;Biochemical;Brain;Chemosensitization;Coupling;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Dense Core Vesicle;dentate gyrus;Electrophysiology (science);Environment;Episodic memory;Event;Exocytosis;experience;Goals;Heart;hippocampal pyramidal neuron;Hippocampus;Impairment;In Situ;In Vitro;insight;Knock-out;Label;Learning;Mammals;Mediating;member;Memory;Memory impairment;memory process;memory retrieval;Microscopy;Molecular;mossy fiber;Mus;nanoenvironment;Nervous System Disorder;neural circuit;Neurodegenerative Disorders;Neurons;Neuropeptides;neuropsychiatric disorder;neurotransmitter release;Pattern;pharmacologic;Phosphorylation;Physiological;Physiology;Play;postsynaptic;presynaptic;Process;Protein Kinase Protein Phosphorylation;Proteins;Proteomics;Research;Resolution;Retrieval;Role;Schizophrenia;Signal Pathway;Signal Transduction;social;Structure;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Synaptic Vesicles;Testing;Vesicle;Visit;way finding

PROJECT_TITLE: Effectors of presynaptic cAMP dependent potentiation at mossy fiber synapses

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Triple negative breast cancer (TNBC) exhibits the highest potential to metastasize, and clustered circulating tumor cells are associated with a significantly higher incidence of breast cancer metastasis. The primary goal of this proposal is to investigate a novel mechanism of cell-cell interaction that promotes tumor cell clustering and metastasis in TNBC. Successfully accomplishing the proposed study will inspire the development of new strategies for the treatment of metastatic TNBC.

PI_NAMEs: CHENG, CHONGHUI  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Adherens Junction;Adhesions;Adhesives;Anoikis;Basic Science;Binding;Biological Assay;Blood;Blood Circulation;Blood specimen;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;cancer cell;cancer subtypes;Cell Communication;Cell model;Cell Survival;Cell-Cell Adhesion;Cells;Characteristics;ChIP-seq;Chromatin;Chromatin Loop;Clinical Data;clinically relevant;Data;Data Analyses;Data Set;Deposition;Development;Disease Progression;Distant;E-Cadherin;Electron Microscopy;Enzymes;Epigenetic Process;epigenetic regulation;Exhibits;experimental study;Extracellular Matrix;Future;gain of function;Genetic Transcription;Goals;Hi-C;Histone-Lysine N-Methyltransferase;Homeobox;Hyaluronic Acid;improved;In Vitro;in vivo;in vivo Model;Incidence;innovation;insight;Intercellular Junctions;Licensing;loss of function;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;Mediator;Metastatic breast cancer;Morbidity - disease rate;mortality;mouse model;Multiomic Data;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Organ;Patients;Physiological;Polysaccharides;pre-clinical;prevent;Primary Neoplasm;Production;Prognosis;promoter;Proteins;receptor;Regulation;Research;Role;Shapes;shear stress;Signal Transduction;Stress;Testing;Therapeutic;transcription factor;transcriptome sequencing;Transmission Electron Microscopy;Travel;triple-negative invasive breast carcinoma;tumor;tumor diagnosis;Tumor Promotion;Work

PROJECT_TITLE: Mechanisms of tumor cell clustering in breast cancer metastasis

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Genetics

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative How transcriptional enhancers communicate with their target promoters persists as one of the central mysteries in cell and developmental biology. We will employ a combination of genome editing, Hi-C contact maps, and quantitative imaging methods to explore the role of chromosomal looping elements--insulators and tethering elements--in the regulation of gene expression in the Drosophila embryo. We will test the hypothesis that looping factors stabilize enhancer-promoter associations by nucleating the formation of transcription hubs: clusters or condensates of transcription factors and RNA Pol II.

PI_NAMEs: LEVINE, MICHAEL STEVEN (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Alleles;Biological Assay;Boundary Elements;Bypass;Cellular biology;Chromosomes;Communication;Complex;Development;Developmental Biology;Distal;DNA;DNA Polymerase II;Drosophila genus;Elements;Embryo;Enhancers;Fostering;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genome editing;genomic locus;Goals;Hi-C;Homeobox Genes;imaging modality;Individual;Insulator Elements;Link;Maps;Modeling;Mutation;Physical condensation;promoter;quantitative imaging;recruit;RNA;Role;Testing;Transcription Coactivator;transcription factor;Transcriptional Activation;Visualization

PROJECT_TITLE: Visualization of gene activity in the Drosophila embryo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: MAYWOOD

ORG_DEPT: BIOLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: PROJECT NARRATIVE Glioblastoma (GBM) is the most common primary malignant brain tumor and expresses the potently immunosuppressive factor indoleamine 2,3 dioxygenase 1 (IDO; IDO1) in >90% of patient-resected cases. The premise of this R01 renewal proposal is to characterize a newly appreciated mechanism of immune resistance that's mediated by GBM cell IDO, as well as to develop and optimize IDO protein degraders as new tools and therapeutic enhancers that fully reverse the immunosuppressive effects of IDO in GBM.

PI_NAMEs: SCHILTZ, GARY E;WAINWRIGHT, DEREK ALAN (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Adult;Affect;Amino Acids;anti-cancer research;anti-tumor immune response;Autologous;Binding;Biodistribution;Brain;Brain Neoplasms;cancer type;Cells;Characteristics;Clinical;Complement Factor H;Complex;Data;design;Development;Engraftment;Enhancers;Enzyme Inhibitor Drugs;Enzymes;Essential Amino Acids;experimental study;expression vector;follow-up;FOXP3 gene;Future;Generations;Glioblastoma;Human;humanized mouse;IL2RA gene;Immune;immune checkpoint blockade;immune resistance;Immune response;Immunobiology;Immunosuppression;Immunotherapy;improved;in vivo;interest;Intracranial Neoplasms;Investigation;Knowledge;Kynurenine;Lead;Malignant neoplasm of brain;Manuscripts;Mediating;Metabolic;Microarray Analysis;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;National Institute of Neurological Disorders and Stroke;National Research Service Awards;Nature;neuro-oncology;Newly Diagnosed;novel;novel therapeutic intervention;novel therapeutics;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Phase III Clinical Trials;Postdoctoral Fellow;Productivity;Property;Protac;protein degradation;Proteins;Publications;reconstitution;recruit;Recurrence;Regulation;Regulatory T-Lymphocyte;Research;Resected;resistance mechanism;Small Interfering RNA;Structure-Activity Relationship;success;T cell infiltration;Testing;Therapeutic;tool;Treatment outcome;Tryptophan;Tryptophan 2,3 Dioxygenase;Tryptophan Metabolism Pathway;Tumor Immunity;ubiquitin-protein ligase;United States National Institutes of Health;Up-Regulation;vector;Work;Xenograft procedure

PROJECT_TITLE: IDO1 and Immunotolerance in Glioblastoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: NARRATIVE The experiments in this proposal will explore cellular pathways involved in the development of pulmonary arterial hypertension (PAH), a devastating disease with limited treatment options. In particular, we will explore whether specific protein-protein interactions featuring aquaporin 1 mediate the smooth muscle and endothelial changes in phenotype that contribute to vascular remodeling during development of pulmonary hypertension and whether these interactions can be targeted to reverse remodeling. Such information is crucial to advancing knowledge of disease pathology and developing new therapeutic options to treat this deadly disease.

PI_NAMEs: SHIMODA, LARISSA A. (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Apoptosis;Apoptotic;AQP1 gene;beta catenin;Binding;Binding Sites;Blood capillaries;Blood Vessels;C-terminal;Cell Adhesion;cell growth;Cell Hypoxia;cell motility;Cell Nucleus;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Complex;cytochrome c;Cytoplasm;Data;Development;Disease;Dissociation;Distal;Endothelial Cells;Endothelium;Epithelial Cells;experimental study;Failure;Family member;glycogen synthase kinase 3 beta;Human;Hypoxia;improved;in silico;Induction of Apoptosis;insight;Ion Channel;Knowledge;Laboratories;Lesion;Lung;lung microvascular endothelial cells;Mediating;migration;Modeling;Molecular;mortality;Muscle;Mutate;novel;novel therapeutics;Nuclear;Nuclear Translocation;Pathology;Pathway interactions;Patients;Permeability;Phenotype;Phosphorylation;Predisposition;prevent;Prevention;Proliferating;Protein Family;protein function;protein protein interaction;Proteins;Publishing;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary arterial remodeling;pulmonary artery endothelial cell;Pulmonary Hypertension;Rattus;Regulation;renal epithelium;Reporting;Repression;Resistance;response;right ventricular failure;Role;Signal Pathway;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Stimulus;Tail;Testing;therapeutic target;Up-Regulation;Vascular Endothelial Cell;Vascular remodeling;Water;water channel

PROJECT_TITLE: Aquaporin 1 and pulmonary hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE - OVERALL The goal of precision therapeutics is to give the right dose of the right drug to the right person at the right time, but rigorous data on precision therapeutics in children and pregnant women are lacking, and there is a shortage of adequately trained investigators in these areas. This Center of Excellence proposal leverages our institutional strengths in Precision Medicine and Bioinformatics to address knowledge gaps in pharmacogenomics and neonatal opioid withdrawal syndrome using innovative analyses of electronic health datasets. Another major goal is the establishment and dissemination of educational resources to create and sustain a physician-scientist workforce in maternal and pediatric precision therapeutics at the national level through collaboration with the National Institute of Child Health and Human Development.

PI_NAMEs: KANNANKERIL, PRINCE JOSEPH (contact);VELEZ EDWARDS, DIGNA R

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Academic Medical Centers;Address;Adoption;Affect;Algorithms;Area;Artificial Intelligence;Attitude;Bioinformatics;biomedical informatics;Child;Child health care;Childhood;Clinical;clinical care;Clinical Research;clinically actionable;cohort;Collaborations;Collection;Communities;community engaged approach;Data;Data Linkages;Data Science;Data Set;data sharing;Development;Devices;disability;Disabled Persons;Discipline of obstetrics;Disease;disparity reduction;Dose;Education;education resources;eHealth;electronic data;electronic health data;Electronic Health Record;Ensure;Environment;Exclusion;experience;Fostering;Foundations;Future;Generations;Genes;Genomics;Goals;Grant;Healthcare;healthy pregnancy;human disease;implementation science;improved;Individual;Infant;Infrastructure;innovation;Institution;interdisciplinary approach;International;investigator training;Investments;Knowledge;knowledge base;Label;Lactation;large datasets;Leadership;Machine Learning;maternal outcome;medication for opioid use disorder;Methodology;Modeling;Mothers;multidisciplinary;National Institute of Child Health and Human Development;Nature;Neonatal Abstinence Syndrome;novel;Opioid;opioid exposure;opioid use disorder;Outcome;Pediatrics;Persons;Pharmaceutical Preparations;Pharmacogenetics;Pharmacogenomics;Pharmacology Study;Phenotype;Physicians;Population;Positioning Attribute;Postpartum Period;Postpartum Women;precision medicine;Precision therapeutics;Pregnancy;pregnant;Pregnant Women;programs;Research;Research Personnel;Research Training;Resources;response;Sampling;Scientist;Strategic Planning;support tools;Testing;Therapeutic;Therapeutic Research;therapeutically effective;Time;tool;Training;Training Activity;training opportunity;Training Support;translational applications;Translational Research;Translations;United States National Institutes of Health;Variant;Woman;Work

PROJECT_TITLE: Vanderbilt Integrated Center of Excellence in Maternal and Pediatric Precision Therapeutics (VICE-MPRINT)


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Patient Safety;Pediatric;Precision Medicine;Prevention;Primary Health Care;Women's Health Research

PI_NAMEs: VAN DRIEST, SARA LYNN (contact)

PROJECT_TERMS: Attitude;biobank;Child;Child health care;Childhood;Chronic;Chronic Disease;Clinical;clinical implementation;Clinical Research;clinically actionable;clopidogrel;cohort;community engaged approach;community engagement;Data;Data Set;disability;Disabled Persons;disparity reduction;DNA;drug metabolism;drug response prediction;Electronic Health Record;Enzymes;European ancestry;evidence base;experience;Frequencies;Future;gene interaction;General Population;Genes;genetic variant;Genomics;Goals;Health;High Prevalence;Individual;Individual Differences;innovation;Knowledge;Label;Lactation;Light;Methods;Minority;Minority Groups;National Institute of Child Health and Human Development;next generation sequencing;novel;Ondansetron;Outcome;Participant;Pharmaceutical Preparations;Pharmacogenetics;Pharmacogenomics;Phenotype;phenotypic data;Physiological;Physiology;Population;Population Heterogeneity;post pregnancy;precision medicine;Precision therapeutics;Pregnancy;pregnant;Pregnant Women;Proton Pump Inhibitors;Reporting;Research;Resources;response;Signal Transduction;Site;study population;Surveys;Test Result;Testing;tool;Validation;Variant;variant of interest;Warfarin;whole genome;Woman;Work

PROJECT_TITLE: Supporting Precision Medicine for Maternal and Pediatric Care through Pharmacogenomics Research


NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative Aggressive B cell lymphomas are a very common type of cancer with varied outcomes for patients—some are cured with standard treatment, but others are not. The goal of this research is to identify biomarkers that can identify which patients are likely to be cured, and which patients might need new treatments. The biomarkers may also tell us if certain types of immune targeting therapies would be useful for certain types of patients.

PI_NAMEs: MERCHANT, AKIL  (contact)

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Address;Adoption;Adult;Algorithms;B-Cell Lymphomas;B-Lymphocytes;Biological Markers;Biological Models;biomarker identification;cancer cell;cancer type;candidate marker;candidate validation;Cell Separation;Cells;Chemoresistance;Childhood;Classification;Clinical;cohort;Cytometry;Development;digital imaging;Elements;Ensure;Gene Expression;Genetic;Goals;Histologic;Histology;Human;Human Herpesvirus 4;Image;Image Analysis;Immune;Immune checkpoint inhibitor;Immune Targeting;Immunohistochemistry;Immunophenotyping;Immunotherapy;In Vitro;in vitro Model;in vivo Model;insight;Institution;International Prognostic Index;large cell Diffuse non-Hodgkin's lymphoma;Link;Lymphoma;Malignant Neoplasms;Mediating;Methods;Modeling;Molecular;Molecular Profiling;Mus;Nature;neoplastic cell;next generation;Non-Hodgkin's Lymphoma;Non-Malignant;novel;novel strategies;Oncogenic;Outcome;Pathologist;Patient-Focused Outcomes;Patients;PD-1/PD-L1;Phenotype;pre-clinical;Preclinical Testing;predictive marker;Prognostic Marker;programmed cell death ligand 1;protein biomarkers;Publishing;Research;Resistance;Resolution;Resources;response;Role;Sample Size;Sampling;single cell analysis;standard care;Structure;Subgroup;survival prediction;Systems Biology;targeted agent;targeted cancer therapy;targeted treatment;Testing;Tissues;Training;tumor;tumor growth;Tumor Markers;tumor-immune system interactions;Validation;Work

PROJECT_TITLE: Spatially resolved, single cell biomarkers of B cell lymphoma

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Data Science;Health Services;Maternal Health;Maternal Morbidity and Mortality;Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Substance Misuse;Women's Health Research

PI_NAMEs: PATRICK, STEPHEN W (contact)

PROJECT_TERMS: Acceleration;Accountability;Address;Admission activity;adverse outcome;Affect;Algorithms;Biological;Birth;Birth Weight;Breast Feeding;Buprenorphine;Cessation of life;Child;Child Welfare;Childhood;Clinical;Code;Collaborations;criminal behavior;Data;Data Linkages;Data Science;data sharing;Databases;Diagnosis;Diagnostic;Drug Monitoring;Drug Prescriptions;Early Intervention;Educational workshop;Electronic Health Record;Eligibility Determination;Emergency department visit;Enrollment;experience;Exposure to;Fostering;Fright;Government;high risk;holistic approach;Hospital Costs;Hospitals;improved;Incidence;Infant;Information Systems;innovation;Inpatients;Intervention;Knowledge;Length of Stay;Link;Literature;Maternal Mortality;maternal opioid use;maternal outcome;Medicaid;medication for opioid use disorder;Methadone;Methodology;Methods;Minority;Morbidity - disease rate;Mothers;multiple data sources;National Institute of Child Health and Human Development;Neonatal;Neonatal Abstinence Syndrome;novel;Opioid;opioid epidemic;opioid exposure;opioid use;opioid use disorder;Outcome;Overdose;overdose death;overdose risk;Personal Satisfaction;Pharmaceutical Preparations;Population;postnatal;Postpartum Period;Postpartum Women;precision medicine;Precision therapeutics;Pregnancy;Pregnant Women;Premature Birth;prenatal;programs;prospective;Recommendation;relapse risk;Research;Research Personnel;Risk;scalable algorithms;service intervention;service utilization;Services;severe maternal morbidity;Syndrome;Tennessee;Testing;Therapeutic;Well baby checks;Withdrawal;Woman;women's outcomes;Women's study

PROJECT_TITLE: Leveraging Data Science to Understand Outcomes for Mothers and Children Affected by Opioids


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: RELEVANCE TO PUBLIC HEALTH This proposal is relevant to public health because it addresses critical shortcomings of currently available methods for studying the relationship between cells and their microenvironment. The development of the proposed molecular, microfluidic, and computational tools will advance understanding of the role of fluid transport in regulating biological processes. In addition to laying the foundation for studying disease mechanisms that are not well captured by current model systems, the results of this work will inform the development of interventional approaches for the myriad diseases in which pathologic fluid transport plays a role, including cardiovascular disease and cancer.

PI_NAMEs: POLACHECK, WILLIAM J (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Biological;Biological Models;Biological Process;Cardiovascular Diseases;Cell Adhesion;Cell Surface Receptors;Cells;Cellular biology;Communities;computerized tools;Development;Disease;disease mechanisms study;disease model;Engineering;Family;fluid flow;Foundations;Future;Goals;Human;interdisciplinary approach;interest;Laboratories;Laboratory Research;Liquid substance;Malignant Neoplasms;Maps;mechanotransduction;Methods;Microfabrication;Microfluidic Microchips;Microfluidics;Molecular;Molecular Biology;molecular scale;Morphogenesis;Movement;notch protein;novel;Pathologic;Porosity;Process;programs;Public Health;receptor;Research;response;Role;Signal Transduction;Techniques;Technology;therapy development;Tissues;tool;Training;translational applications;Work

PROJECT_TITLE: Integrative Approaches for the Study of the Fluidic Cellular Microenvironment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: SAINT JOSEPH MERCY HEALTH SYSTEM

ORG_STATE: MI

PHR: PROJECT NARRATIVE The overall goal of NCORP is to bring cancer clinical research studies to individuals in their own communities, thereby generating a broadly applicable evidence base that contributes to improved patient outcomes and a reduction in cancer disparities.

PI_NAMEs: AL BAGHDADI, TAREQ  (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Affect;anti-cancer research;Area;biobank;Biological;cancer care;Cancer Center;Cancer Control;cancer health disparity;cancer prevention;cancer therapy;care delivery;Caring;Clinical Research;Clinical Trials;Communities;community based research;Community Clinical Oncology Program;Community Health;Complex;Comprehensive Cancer Center;Development;Disparity;disparity reduction;evidence base;experience;Funding;Funding Agency;Genomics;Goals;Health system;Hospitals;Human Subject Research;Immune system;Immunologics;improved;Individual;Infrastructure;innovation;Intervention;Knowledge;Lead;Malignant Neoplasms;Massachusetts;Michigan;Mission;Molecular Target;National Cancer Institute;National Clinical Trials Network;next generation;Oncology;Patient-Focused Outcomes;Patients;Pennsylvania;Performance;Process;Productivity;programs;Protocols documentation;Research;Research Personnel;research study;Resources;Saints;screening;Site;symptom science;Tissues;Vision

PROJECT_TITLE: Michigan Cancer Research Consortium NCORP


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative Major Depressive Disorder (MDD) is characterized by poor memory for positive events. This positive memory deficit exacerbates the hopelessness that characterizes MDD, and it may be a critical target for treatment—but, unfortunately, the underlying mechanisms are poorly understood. The current project will address this knowledge gap by using electroencephalography (EEG) and computational modeling to study the encoding and retrieval of positive memories in adults with MDD, and by testing whether mirth induction can alleviate the deficit by increasing positive affect and thus restoring neural responses to positive stimuli.

PI_NAMEs: MAKSIMOVSKIY, ARKADIY LEONIDOVICH (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Adult;Affect;American;Clinical;clinically significant;Computer Models;Data;Depressed mood;depressive symptoms;design;Development;Diagnosis;Diffusion;dopaminergic neuron;Electroencephalography;Emotional;Environment;EP300 gene;Event;Event-Related Potentials;Exhibits;Expectancy;Feeling hopeless;Fire - disasters;Goals;Grant;Happiness;Healthcare Systems;Hippocampus;Hospitals;Hour;Image;improved;Individual;Intervention;Interview;Knowledge;Laughter;Learning;Link;locus ceruleus structure;long term memory;Major Depressive Disorder;Measures;Mediating;member;Memory;memory consolidation;memory encoding;Memory impairment;memory recognition;memory retrieval;Mental Depression;Mentors;Methods;Modeling;Moods;neural;neuroimaging;neuromechanism;Neurons;Norepinephrine;P300 Event-Related Potentials;Participant;Performance;Persons;Pilot Projects;positive mood;Process;Psychological reinforcement;reconstruction;Research;response;Retrieval;Sampling;Sensory;Severities;Signal Transduction;skills;Speed;Stimulus;Stream;Symptoms;System;Techniques;Testing;Training;Translating;Translational Research;Ventral Tegmental Area;Writing

PROJECT_TITLE: Inducing Mirth to Improve Memory in Depression


NIH_SPENDING_CATS: Pediatric;Precision Medicine

PI_NAMEs: KANNANKERIL, PRINCE JOSEPH (contact)

PROJECT_TERMS: Academy;Address;Administrator;Annual Reports;Charge;Childhood;Clinical Research;Clinical Trials;Collaborations;Data;Data Analyses;Data Science;Data Set;data sharing;Discipline;Discipline of obstetrics;doctoral student;eHealth;Environment;experience;faculty support;Funding;Goals;Grant;Gynecology;Healthcare;Human Resources;improved;innovation;Institution;Knowledge;Leadership;meetings;Mentored Clinical Scientist Development Program;Methodology;Methods;Modeling;multidisciplinary;National Institute of Child Health and Human Development;Nature;Neonatal Abstinence Syndrome;novel;Office of Administrative Management;outreach;Pediatrics;Pharmacogenomics;pharmacometrics;Policies;Population;Postdoctoral Fellow;pre-doctoral;precision medicine;Precision therapeutics;Principal Investigator;programs;Protocols documentation;Qi;Research;Research Personnel;Research Project Grants;Resource Allocation;Resources;Role;Scientist;Structure;success;support tools;Therapeutic Research;tool;Training;Training Activity;Training and Infrastructure;Training Programs;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative Aberrant regulation of stem cells by their niche can severely affect human health by causing tumor formation or tissue atrophy. Therefore we must improve our understanding of niche function as it pertains to stem cell regulation. This project will uncover the principles of how a niche is initially positioned during development, how this precise positioning is critical to niche function, and whether a niche receives feedback from the tissue it supports.

PI_NAMEs: NELSON, KARA  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TITLE: Mechanism of niche formation, and impact of niche position on tissue function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Women's Health Research

PI_NAMEs: WEI, WEI-QI  (contact)

PROJECT_TERMS: Adoption;Adverse event;Algorithms;analytical tool;application programming interface;base;biobank;Birth;Blood Pressure;Child;Childhood;Clinical;clinical care;Code;Collaborations;Communities;Data;data modeling;Data Set;data standards;design;Development;Diagnosis;Discipline of obstetrics;Drug Exposure;Electronic Health Record;Electronics;Ensure;experience;genome-wide;Genotype;Goals;Health Care Visit;Healthcare;Individual;infant outcome;Knowledge;knowledgebase;Machine Learning;maternal outcome;Medical;Methods;Modification;Natural Language Processing;Natural Language Processing pipeline;Neonatal Abstinence Syndrome;novel;Outcome;Patients;Performance;Pharmaceutical Preparations;Pharmacogenomics;Phenotype;phenotyping algorithm;Population;Precision therapeutics;Pregnancy;Pregnant Women;Publishing;Research;Research Personnel;Resources;Schedule;Services;Signal Transduction;Site;Source;Techniques;Terminology;Therapeutic Research;tool;treatment response;United States;Validation;web site;Weight;Woman;Work

PROJECT_TITLE: Phenotyping Support Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Hypertension affects half of American adults but poses an especially severe burden on African Americans. Understanding and eliminating disparities in hypertension and related social determinants of health is a national research priority identified in NHLBI’s Strategic Vision. This project will leverage unique opportunities in spatial epidemiology to quantify the fraction of hypertension disparities that can be eliminated by addressing disparities in geographic areas’ socioeconomic characteristics and structural environmental resources.

PI_NAMEs: ABDEL MAGID, HODA  (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Address;Adult;Affect;African American population;Age of Onset;American;Area;Biometry;Black Populations;Black race;Businesses;Cardiovascular Diseases;cardiovascular health;career;career development;Characteristics;cohort;Data;Data Mart;Data Sources;deprivation;Development;Diagnosis;Disparity;disparity elimination;Education;Environment;Epidemiology;ethnic minority;Ethnic Origin;Food;Geographic Locations;Geography;health disparity;Health Food;Healthcare;Housing;Hypertension;hypertension control;hypertension treatment;improved;Incidence;Income;indexing;Individual;Inequality;innovation;Intervention;Link;Location;Low income;Measures;Mediating;Medicare;Medicare/Medicaid;Methods;Modeling;multidisciplinary;National Heart, Lung, and Blood Institute;Outcome;Participant;Pathway interactions;Pattern;Population;Population Heterogeneity;Population Surveillance;Prevalence;Privatization;Process;Race;racial difference;racial disparity;racial minority;Reasons for Geographic And Racial Differences in Stroke;Recreation;Research;research and development;Research Personnel;Research Priority;residential segregation;Resources;Risk Factors;Sampling;skills;social;social health determinants;social interventions;socioeconomics;spatial epidemiology;Strategic vision;Stroke;Training;United States

PROJECT_TITLE: Leveraging Spatial Epidemiology to Reduce Hypertension Disparities

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Organ Transplantation;Social Determinants of Health;Substance Misuse;Transplantation

PHR: PROJECT NARRATIVE Alcohol-associated liver disease (ALD) is a major cause of acute and chronic liver failure and is now the most common reason for liver transplantation in the U.S. Historically, transplant centers have required at least 6 months of alcohol abstinence before considering patients with ALD for liver transplant; however early liver transplant for patients with severe ALD with less than 6 months of alcohol abstinence can save lives. This multi- center study will examine the patient selection process for early liver transplantation, identify strategies most helpful to prevent return to alcohol use and to optimize long-term health after transplant.

PI_NAMEs: TERRAULT, NORAH A. (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Abstinence;Acceleration;access disparities;Accounting;Acute;addiction;Address;Adult;alcohol abstinence;Alcohol consumption;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;American;Ancillary Study;Behavior Therapy;Behavioral;biobank;Blood;candidate selection;Cardiovascular system;Caring;Cessation of life;Chronic;Cirrhosis;Clinical;Clinical Pathways;clinical predictors;cohort;community-level factor;comorbidity;Consensus;Continuity of Patient Care;Data;data repository;deprivation;disorder control;drinking;effective therapy;effectiveness evaluation;efficacy evaluation;Eligibility Determination;end stage liver disease;Enrollment;Evaluation;Event;Exclusion;experience;Failure;Future;Geography;graft function;Graft Rejection;Health;health care disparity;Health Status;Heavy Drinking;Hepatitis;Heterogeneity;high risk;Hospital Costs;Hospitalization;implicit bias;improved;Incidence;Individual;Interview;Knowledge;Life;Link;Liver;Liver diseases;Liver Failure;liver transplantation;Longitudinal cohort;Malignant Neoplasms;Medical;medication-assisted treatment;meetings;Mental Health;Methods;Midwestern United States;Modeling;mortality;mortality risk;Multicenter Studies;multilevel analysis;Natural History;Neighborhoods;Organ;organ allocation;Outcome;Patient Outcomes Assessments;Patient Selection;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;Pharmacotherapy;Phenotype;Policies;prevent;Procedures;Process;Prognosis;Prognostic Factor;prolonged abstinence;prospective;psychosocial;Psychosocial Factor;Quality of life;radiological imaging;recruit;Risk;risk prediction;Safety;Sample Size;Selection Criteria;Site;sobriety;social health determinants;Social support;sociodemographics;Sodium Chloride;Source;Standardization;Substance Use Disorder;Systematic Bias;Tissue Donors;Tissues;transplant centers;Transplant Recipients;Transplantation;Transplanted Liver Complication;treatment program;Urine;Waiting Lists

PROJECT_TITLE: 1/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: San Francisco

ORG_NAME: SOCIETY FOR THE ADV CHICANOS/NATIVE AMER

PHR: NARRATIVE:   Biomedical  and  Behavioral  Science  research  education  programs  across  the  nation  are  faced  with  challenges  (e.g.  changing  job  markets),  and  potential  opportunities  (e.g.  large  diverse  population),  that  must  be  collectively  considered  to  meet  the  needs  of  the  nation  and  drive  innovations.  SACNAS  (the  Society  for  Advancement  of  Chicanos/Hispanics  and  Native  Americans  in  Science),  the  largest  multicultural  and  multidisciplinary  STEM  diversity  organization  in  the  nation  with  a  more  than  46- year  history,  is  ideally  positioned  to  address  these  challenges.  SACNAS  will  develop  career  trainings  for  its  established  network  of  underrepresented  minority  students  and  postdoctoral  fellows  to  enhance  retention,  build  leadership  skill  sets,  increase  workforce  diversity,  and  facilitate  progress  along  various  career  tracks  (academia,  industry,  government,  nonprofits)  within  the  Biomedical  and  Behavioral  Sciences disciplines.

PI_NAMEs: PADILLA, PAMELA ANNE (contact)

PROGRAM_OFFICER_NAME: BROWN, ANISSA F

PROJECT_TERMS: Academia;Address;Award;Awareness;Behavioral;Behavioral Research;Behavioral Sciences;Biomedical Research;career;Career Choice;Career Mobility;career networking;Clinical Research;Communities;Competence;Complement;demographics;Developing Countries;Development;Discipline;Diverse Workforce;Doctor of Philosophy;Education;education research;Educational Status;Face;Faculty;Fostering;Government;Grant;Hispanic Americans;Home;Industry;innovation;Institution;job market;Knowledge;Leadership;leadership development;Mentorship;Mexican Americans;minority scientist;minority student;multidisciplinary;Native Americans;Outcome;Population;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;Productivity;Program Development;programs;Recording of previous events;recruit;Research Personnel;Resources;role model;Science;skills;Societies;STEM field;STEM research;student mentoring;student training;Students;success;symposium;Training;undergraduate student;Underrepresented Minority;underrepresented minority student

PROJECT_TITLE: Culturally Responsive Academic and Career Trainings to Diversify the Biomedical Workforce


FUNDING_MECHANISM: OTHERS

ORG_CITY: SOUTH PORTLAND

ORG_STATE: ME

PHR: Narrative  The Department of Energy and predecessor agencies have been involved in the research, production and testing of nuclear weapons since the 1940s. During that time, numerous facilities, both government and privately-owned, were constructed or leased across the country to support the effort, generating large quantities of radioactive and hazardous materials that resulted in the contamination of many of the facilities and surrounding areas.  In 1994, to protect the staff and workers doing DOE cleanup and waste management work, legislation was enacted to allow the Department of Energy to fund NIEHS to develop Worker Training programs that would assure workers, other facility personnel, and community responders the knowledge and skills to protect themselves and their communities from hazardous conditions in the workplace.  The National Partnership for Environmental Technology Education (PETE) and its Community College Consortium for Health and Safety Training (CCCHST) has been continuously supported by NIEHS since 1995 to provide quality training that is efficient, consistent, flexible, and cost-effective for the multiple tiers of contractors at DOE sites including the Oakridge complex, Pantex, the Savannah River Site, with Los Alamos National Lab soon to be added, annually providing 7,000 students with 400 courses for a total 50,000 contact hours of training, with an average 75 courses delivered online.

PI_NAMEs: NASH, WILLIAM KESTER (contact)

PROGRAM_OFFICER_NAME: BEARD, SHARON

PROJECT_TERMS: Advisory Committees;Area;Award;chemical disaster;Communities;community college;Complex;Contractor;cost effective;Country;Data;Data Management Resources;Decontamination;Department of Energy;Educational Curriculum;Educational Technology;Emergency response;Evaluation;Exposure to;flexibility;Funding;Goals;Government;Hazardous Substances;Hazardous Waste;Hazardous Waste Sites;Health;Hour;Human Resources;Knowledge;Laboratories;Mediating;member;National Institute of Environmental Health Sciences;Nuclear Weapon;Nuclear Weapons Testings;online delivery;operation;Privatization;Production;Quality Control;Radioactive;Research;response;restoration;Safety;Site;skills;Statutes and Laws;student training;Students;technical college;Tennessee;Time;Training;Training Programs;Transportation;Universities;virtual;Waste Management;wasting;Work;Workplace

PROJECT_TITLE: HAZMAT Training at DOE Nuclear Weapons Complex


ORG_CITY: MERCED

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

PHR: Project Narrative The molecular motions of proteins underlie many important biological phenomena, such as allostery, yet they remain challenging to study at high spatial and temporal resolution. The goal of the proposed research is to implement a novel approach that combines temperature perturbations with structural, biochemical, and biophysical measurements to provide insight into the allosteric regulation of protein molecules that have key functions in health and disease. The knowledge generated from these studies will deepen our understanding of human biology and provide information that is actionable for drug discovery.

PI_NAMEs: THOMPSON, MICHAEL C. (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Allosteric Regulation;Biochemical;Biological Assay;Biological Phenomena;Biological Process;biophysical properties;Biophysics;Clinical;Collection;Communities;Computer software;Crystallography;Data Analyses;Democracy;Disease;drug discovery;Drug Targeting;Enzymes;Equilibrium;Family;Generations;Goals;Health;Human Biology;improved;insight;Knowledge;Length;Measurement;Methods;Molecular;Molecular Chaperones;Molecular Conformation;Motion;novel strategies;Orthologous Gene;Peptide Hydrolases;Phosphotransferases;Protein Conformation;protein function;protein structure;Proteins;Regulation;Research;response;structural biology;Structure;Structure-Activity Relationship;Temperature;temperature jump;temporal measurement;Therapeutic;Time;time use;tool;Work;X-Ray Crystallography

PROJECT_TITLE: Exploiting temperature-sensitive orthologs to understand protein allostery


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  The behavioral response of an organism to its environment is the output of many synaptic, neuronal, and circuit processes that are regulated by a complex network of genes and proteins. Synaptic adhesion molecules are crucial for neuronal circuit function, as evidenced by their association with conditions characterized by changes in behavior, including autism and schizophrenia. To overcome challenges presented by the extreme complexity of neuronal circuits and synaptic adhesion genes in vertebrates, we will use modern neuroscience and genetic techniques in C. elegans to investigate the coordination and molecular mechanisms of many conserved synaptic adhesion genes across multiple conserved foraging behaviors and circuits.

PI_NAMEs: HART, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Adhesions;autism spectrum disorder;Behavior;Behavioral;behavioral plasticity;behavioral response;Caenorhabditis elegans;Cell Adhesion Molecules;Complex;Discipline;Disease;Dissection;Environment;experience;Experimental Models;experimental study;gene conservation;Gene Family;gene function;gene interaction;gene network;Generations;Genes;Genetic;Genetic Techniques;Goals;graduate student;Mentors;Modeling;Modernization;Molecular;Nematoda;Neurodevelopmental Disorder;neuronal circuitry;Neuronal Plasticity;Neurons;neuropsychiatric disorder;Neurosciences;novel;Organism;Orthologous Gene;Output;Planning Techniques;Postdoctoral Fellow;prevent;Process;Protein Isoforms;Proteins;Reiterated Genes;Research;Resolution;Role;Schizophrenia;Structure;Synapses;System;Training;undergraduate student;Vertebrates;Work

PROJECT_TITLE: Molecular coordination of adhesion molecules in foraging behaviors and circuits

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Genetic defects in RUNX1, a master regulator of hematopoiesis and leukemogenesis, have frequently been identified in myeloid neoplasms particularly acute myeloid leukemia. Leukemogenic RUNX1 mutations may possess potential mutant-specific functionality and cooperate with other mutations in promoting leukemia and lineage specification. Our work aims to use our newly developed inducible and reversible RUNX1 mutant mouse models, a large cohort of RUNX1 mutant patients with banked samples, and basic molecular techniques to understand the molecular mechanism of mutant RUNX1 mediated leukemogenesis and lineage specification and identify novel targeted therapies in this pathway.

PI_NAMEs: XIAO, WENBIN  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia 1 protein;Address;Alleles;Antigens;Attenuated;Automobile Driving;Bioinformatics;Biometry;career development;Cells;Chemoresistance;Clinical;cohort;Collaborations;college;Data;Dedications;Dependence;Development;Development Plans;Disease;Doctor of Philosophy;Embryo;Epigenetic Process;epigenetic regulation;epigenomics;Event;Exhibits;Funding;Future;Gene Expression Profile;gene regulatory network;Genes;Genetic;Genetic Heterogeneity;Germ Lines;Goals;Hematologic Neoplasms;Hematopoiesis;Hematopoietic stem cells;Immunophenotyping;Knockout Mice;Knowledge;Laboratories;leukemia;leukemic transformation;leukemogenesis;Lymphoid;Maintenance;Mediating;Medicine;member;Memorial Sloan-Kettering Cancer Center;Mentors;Modeling;Molecular;mouse model;Mus;mutant;mutant mouse model;Mutate;Mutation;Myelogenous;Myeloproliferative disease;new therapeutic target;novel;Oncogenic;Output;Paper;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Play;Pre-Clinical Model;Prognosis;prognostic;programs;Publishing;recombinase;Recurrence;Research;Research Personnel;Resolution;restoration;Role;Sampling;Shapes;skills;Specific qualifier value;Techniques;Testing;therapy resistant;Time;Training;transcriptomics;Work

PROJECT_TITLE: Assessing lineage infidelity, oncogenic cooperativity and dependency in RUNX1-mutant acute myeloid leukemia

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Lyme Disease;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: COLLEGE PARK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE Lyme disease, caused by the tick-borne bacterial pathogen Borrelia burgdorferi, persists in the United States and parts of Europe. The project focuses on understanding how a select set of B. burgdorferi antigens that support microbial virulence contributes to pathogen persistence in the tick-rodent infection cycle and pathogenesis in mammalian hosts. Knowledge of these processes is critical for the development of novel preventative and/or therapeutic strategies to combat the infection.

PI_NAMEs: PAL, UTPAL  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Amino Acids;Anti-Infective Agents;Antibiotic Therapy;Antigens;antimicrobial;Arthropod Vectors;Bacteria;Binding;Biological;Biological Products;Biology;Black-legged Tick;Borrelia;Borrelia burgdorferi;Borrelia burgdorferi Group;C-terminal;Cells;Chronic;Clinical;combat;Complex;Crystallization;design;Development;Dimensions;Early Diagnosis;enzootic;Epitopes;Europe;Event;experience;extracellular;gene conservation;gene product;Genome;Goals;High temperature of physical object;Human;Impairment;Infection;Infection Control;insight;Investigation;Ixodes;Knowledge;Length;Lyme Disease;lyme pathogenesis;Mammals;Measures;Mediating;Membrane;Membrane Proteins;microbial;Molecular Chaperones;N-terminal;Nature;novel;novel therapeutic intervention;novel therapeutics;novel vaccines;Order Spirochaetales;pathogen;Pathogenesis;pathogenic bacteria;patient subsets;Peptide Hydrolases;Peptidoglycan;Pharmaceutical Preparations;Phase;polypeptide;Post Treatment Lyme Disease Syndrome;Process;protein function;Protein Inhibition;protein protein interaction;Proteins;Proteolytic Processing;Recombinants;Relapse;Rodent;Role;Series;small molecule;Spirochaetales Infections;standard care;Structure;Symptoms;Therapeutic;Tick Infestations;tick transmission;tick-borne;Tick-Borne Infections;Ticks;Translation Process;transmission process;United States;vaccine development;Vaccines;vector tick;Virulence

PROJECT_TITLE: Borrelia gene products critical for natural infection cycle

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-R(02)M]


ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: Project Narrative Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene are a recently discovered cause of autosomal dominant, familial Parkinson's disease (PD). Our studies aim to explore novel mechanisms by which mutant forms of VPS35 lead to dopaminergic neuronal degeneration in rat models of PD. These studies will have important implications for understanding the molecular pathophysiology of VPS35-associated PD and for future drug development efforts.

PI_NAMEs: MOORE, DARREN JOHN (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Adult;Animal Model;autosome;axonal degeneration;Biological Process;Brain;brain tissue;Catecholamines;Cell membrane;Cells;Clinical;Complex;Corpus striatum structure;Cytopathology;Development;Diet;Disease;disease model;Disease Progression;dominant genetic mutation;Dominant-Negative Mutation;Dopamine;dopaminergic neuron;Dose;drug development;Endosomes;experimental study;Family;Functional disorder;Future;gain of function;Gene Dosage;Gene Silencing;Gene Transfer;Genes;Golgi Apparatus;Human;Impairment;Individual;innovation;insight;Integral Membrane Protein;kinase inhibitor;Knockout Mice;Lead;Link;loss of function;LRRK2 gene;Mediating;Missense Mutation;Modeling;Molecular;Movement Disorders;Mus;mutant;Mutation;Nerve Degeneration;neurodegenerative phenotype;neuron loss;Neurons;neuropathology;neuroprotection;nigrostriatal dopaminergic pathway;novel;novel therapeutic intervention;Orthologous Gene;Outcome;overexpression;palliative;Parkinson Disease;Pathogenicity;Pathologic;Pathway interactions;pharmacologic;Phenotype;Phosphotransferases;Population;postnatal;protein aggregation;Proteins;Proteomics;Rat Transgene;Rattus;Recycling;Retrieval;Rodent;Rodent Model;Role;segregation;short hairpin RNA delivery;small hairpin RNA;Sorting;Substantia nigra structure;Tissue Model;Tissues;trans-Golgi Network;Transgenes;Transgenic Organisms;Vacuolar Protein Sorting;Variant;Viral;Viral Vector

PROJECT_TITLE: Exploring mechanisms of Parkinson's disease-linked D620N VPS35 in rat models


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cardiovascular;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative We have identified 2.5-fold higher prevalence of doxorubicin-induced cardiotoxicity (DIC) in African American (AA) than European American survivors yet the biological basis of this racial disparity in DIC is poorly understood. We will use human induced pluripotent stem cell-derived cardiomyocytes derived from AA survivors to discover novel genetic variants for DIC and validate the mechanisms by which these genetic variants influence this potentially fatal drug complication. This knowledge will provide clinicians with a validated genomic tool to predict if a patient will experience DIC and a route to discover genotype-specific cardioprotective drugs.

PI_NAMEs: BURRIDGE, PAUL W. (contact);SAPKOTA, YADAV

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Adolescent;Adult;Affect;African American;Age;Algorithms;alternative treatment;American;Anthracycline;Area;ATAC-seq;Biochemical;Biological;Biological Assay;Blastoma;Body mass index;cancer diagnosis;Cancer Patient;Candidate Disease Gene;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cardiotoxicity;chemotherapy;Chest;Child;childhood cancer survivor;Chromatin;Clinical;clinical application;Clinical Data;clinical risk;cohort;Common Terminology Criteria for Adverse Events;Complication;Correlation Studies;Coupled;CRISPR/Cas technology;Cryopreservation;Data;Detection;differential expression;Dose;Doxorubicin;Drug Prescriptions;Drug usage;Enhancers;epigenome;Etiology;European;experience;Exposure to;Gene Expression;Genes;Genetic;Genetic study;genetic variant;Genome;genome editing;genome sequencing;genome wide association study;genomic predictors;genomic tools;Genomics;Genotype;Heart failure;Heart Transplantation;Hematologic Neoplasms;High Prevalence;Human;human induced pluripotent stem cells;human model;In Vitro;Individual;induced pluripotent stem cell derived cardiomyocytes;innovation;interest;Knowledge;leukemia;Linkage Disequilibrium;Lymphoma;Malignant Childhood Neoplasm;Maps;Mediating;member;Metabolism;Methodology;Modality;novel;Oncologist;Online Systems;Participant;Pathway interactions;Patients;pediatric patients;Performance;Pharmaceutical Preparations;Phenotype;Physiological;Predisposition;prevent;Process;promoter;Quantitative Trait Loci;racial disparity;Radiation therapy;RARG gene;Regulatory Element;Research;response;Risk;Risk Factors;risk prediction;risk prediction model;Risk Reduction;RNA Splicing;Role;Route;Saint Jude Children's Research Hospital;Sampling;Sarcoma;sex;Single Nucleotide Polymorphism;Solid;Survivors;Time;tool;transcriptome;transcriptome sequencing;Translating;user-friendly;Validation;Variant;whole genome;Work

PROJECT_TITLE: Predicting and Preventing Chemotherapy-Induced Cardiotoxicity in African American Children