ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Prevention;Racial and Ethnic Minority Health Research;Sarcopenia;Social Determinants of Health;Women's Health Research

ORG_CITY: AMHERST

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE This study is focused on longitudinal change in muscle mass and how it relates to impaired insulin-glucose homeostasis, diabetes, and adverse health outcomes (functional limitation, falls, and fractures) in a diverse cohort of older women (56% from racial/ethnic minority groups). The results will provide insight into mechanisms underlying sarcopenia and diabetes/pre-diabetes that will enhance our ability to develop geroprotective or gerotherapeutic interventions in the future. The novel remote measurement approach for assessment of muscle mass via the D3-creatine (D3Cr) dilution method has potential to revolutionize screening for sarcopenia in clinical settings and public health research.

PI_NAMEs: BANACK, HAILEY ROSE;WACTAWSKI-WENDE, JEAN  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Activities of Daily Living;Address;adjudication;advanced analytics;Affect;Age;age acceleration;age related changes;age-related muscle loss;Aging;aging mechanism;aging process;Algorithms;Area;Basic Science;Biological Markers;black women;Blood;blood glucose regulation;Chronic;Clinical;Clinical Research;clinically relevant;cohort;Collection;Communities;comorbidity;Creatine;Data;Data Analytics;Data Collection;Development;Diabetes Mellitus;Disabling;Disease;Dual-Energy X-Ray Absorptiometry;Epidemiology;epidemiology study;ethnic diversity;ethnic minority population;Ethnic Origin;experience;falls;Feedback;Fingers;follow-up;Fracture;functional decline;Functional impairment;Future;Gait speed;Gender;geroprotector;Geroscience;gerotherapeutic;glycemic control;Goals;hallmarks of aging;Hand Strength;Health;healthspan;healthy aging;High Risk Woman;Hispanic Women;Home;Impairment;improved;Incidence;indexing;innovation;insight;Insulin;Intervention;intervention program;Knowledge;lean body mass;Life;Link;Machine Learning;machine learning method;Magnetic Resonance Imaging;Measurement;Measures;men;Metabolic Pathway;Methodology;Methods;Minority;modifiable risk;Morbidity - disease rate;mortality;Muscle;muscle form;Muscular Atrophy;Not Hispanic or Latino;novel;older adult;older women;Outcome;Participant;Pattern;Pharmaceutical Preparations;Physical Function;Physiological;Population;Population Study;Postmenopause;pre-clinical;Prediabetes syndrome;Prevalence;Probability;programs;Prospective, cohort study;Protocols documentation;Public Health;public health intervention;public health research;Quality of life;Race;racial diversity;racial minority population;racial minority women;rate of aging;reduced muscle mass;Research;Resources;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;sample collection;sarcopenia;screening;sedentary lifestyle;Skeletal Muscle;skeletal muscle wasting;Structural Models;Techniques;therapy design;Time;United States;Woman;Women's cohort;Women's Health;X-Ray Computed Tomography

PROJECT_TITLE: MASS: Muscle and disease in postmenopausal women

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: YEGNASUBRAMANIAN, SRINIVASAN  (contact)

PROJECT_TERMS: 3-Dimensional;Animals;ATAC-seq;Automobile Driving;cancer cell;cancer invasiveness;Cell Nucleus;Cells;Characteristics;chemokine;comparative;CXCL5 gene;Data;Deceleration;Development;Disease;Disease Progression;DNA;Engineering;Epithelium;Fibroblasts;Genetic;Genetic Transcription;genome-wide;Genomics;Germ Cells;Human;imaging approach;Immune Evasion;Immunosuppression;In Situ;Indolent;Infiltration;Inflammatory;Invaded;Knock-out;Lesion;Macrophage;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Mediating;Modeling;Molecular;molecular imaging;molecular pathology;mouse model;Mus;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;novel;Outcome;overexpression;Pathogenesis;Patients;PET/CT scan;pharmacologic;Phenotype;Population;Positron-Emission Tomography;prospective;Prostate;Prostate Adenocarcinoma;Prostatectomy;PTEN gene;receptor;recruit;Reporting;Role;Sampling;Signal Transduction;single nucleus RNA-sequencing;synergism;Testing;Tissues;tumor;tumor progression;tumor-immune system interactions;Up-Regulation

PROJECT_TITLE: Microenvironmental drivers of indolent to aggressive prostate cancer switch mediated by combined MYC Activation and PTEN loss


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Estrogen;Eye Disease and Disorders of Vision;Rare Diseases

ORG_CITY: FORT WORTH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Keratoconus (KC) disease is the degeneration of the corneal stroma, which causes the cornea to slowly change from its’ normal curved shape to a more conical shape, leading to vision distortion. Unfortunately, to-date, the etiology of the disease is unknown, and in most cases, patients require some kind of surgical intervention. The proposed studies have potential to revolutionize the field and establish new diagnostic and treatment approaches.

PI_NAMEs: KARAMICHOS, DIMITRIOS  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Adrenal Glands;Affect;Age;Androgens;Anterior Pituitary Gland;Area;Astigmatism;Basic Science;Biochemical;Biological Markers;Blindness;Blood;Cell Physiology;Cells;Cicatrix;Circulation;Clinical;clinically relevant;cohort;Collagen;Complex;Contact Lenses;Cornea;Corneal Diseases;Corneal Stroma;crosslink;Data;dehydroepiandrosterone;design;Detection;Development;Diagnosis;Disease;Down-Regulation;Endocrine;Equilibrium;Estriol;Estrogens;Estrone;Etiology;Eye diseases;Eye Injuries;Feedback;Fibrosis;Follicle Stimulating Hormone;Functional disorder;Funding;Goals;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;Gonadotropin-Releasing Hormone Receptor;Gonadotropins;Health;Hormonal;Hormone Receptor;Hormone secretion;Hormones;Human;hypothalamic pituitary gonadal axis;Hypothalamic structure;improved;In Vitro;in vitro Model;in vivo;insight;Investigation;Keratoconus;Keratoplasty;Knowledge acquisition;Legal patent;Life;Link;Luteinizing Hormone;Measures;Mediating;Metabolism;Mitochondria;mitochondrial genome;Monitor;Myopia;novel;novel diagnostics;ocular surface;Operative Surgical Procedures;Pathogenesis;Patient Care;Patients;Persons;Pituitary Gland;Plasma;Population;pregnant;prevent;Prevention;programs;Prolactin;Proteins;Public Health;Publishing;Race;receptor;Recovery;Recurrence;Reporting;Research;Research Priority;Role;Saliva;Same-sex;Sampling;Severities;sex;Shapes;Signal Transduction;Stromal Cells;Teenagers;Thinness;Time;Tissues;tool;Up-Regulation;Variant;Vision;Visual disability;Visual impairment;Work

PROJECT_TITLE: The Intimate Interplay Between Keratoconus, Sex Hormones, and the Anterior Pituitary

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(02)M]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Prostate Cancer;Urologic Diseases

PI_NAMEs: SZALAY, ALEXANDER S (contact)

PROJECT_TERMS: Architecture;Astronomy;Berry;big-data science;bisulfite sequencing;Cell Nucleus;Cells;Characteristics;Chromatin;computational platform;Computer Analysis;computer framework;cost effective;Coupled;Data;data integration;data streams;Databases;Dedications;Development;digital pathology;diverse data;DNA Methylation;epigenomics;Epithelial Cells;Epithelium;Equipment;Functional Imaging;Gene Expression;Genetically Engineered Mouse;genome-wide;Genomic approach;genomic data;Genomics;Goals;Growth;high dimensionality;Human;Human Resources;Image;Image Analysis;image processing;imaging approach;Immune Evasion;Immune response;Immunofluorescence Immunologic;Immunohistochemistry;immunopathology;In Situ;In Situ Hybridization;Indolent;Inflammation;Inflammatory;Informatics;Infrastructure;innovation;Laboratories;Lasers;Lesion;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Mathematics;Measurement;Measures;Mediating;Metadata;Methodology;Methods;Microscope;Modality;Modeling;Molecular;molecular array;molecular imaging;molecular pathology;mRNA Expression;multidimensional data;multimodal data;multimodality;Mus;Natural regeneration;Neoplasms;neoplastic cell;novel;novel strategies;Pathologic;Pathology;pathology imaging;Pattern;Phenotype;programs;Prostate;relational database;Reporting;Research Design;Research Personnel;Research Support;Resolution;Resources;Sampling;Scanning;Science;Services;single cell genomics;single nucleus RNA-sequencing;Slide;spectrograph;Statistical Algorithm;Statistical Data Interpretation;statistics;System;Systems Biology;Technology;Testing;Tissues;tool;transcriptome sequencing;transcriptomics;transfer learning;translational potential;Translations;tumor microenvironment;Work;XCL1 gene

PROJECT_TITLE: AstroPath Integration Resource Core


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

ORG_STATE: NY

PHR: Project Narrative This project will identify precision treatment regimens for individuals with schizophrenia that are effective for many of its clinical manifestations and associated comorbidities through novel machine learning applications to large observational datasets including electronic health records and claims data previously prohibitively complex to test with clinical trials. These treatment regimens provided to individuals clustered by common characteristics in the datasets, and whose efficacy is validated in comparative effectiveness studies, will define personalized treatment rules for clinicians to use when treating individuals with schizophrenia. These rules will be further tested to determine whether they help clinicians identify effective treatments early in the illness trajectory leading to better outcomes and will enhance existing evidence-based practices with this new person- centered approach.

PI_NAMEs: BAREIS, NATALIE  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;adjudication;adverse outcome;affective disturbance;Age;Antipsychotic Agents;Anxiety;burden of illness;Characteristics;Classification;Clinical;Clinical Data;clinical practice;Clinical Research;Clinical Treatment;Clinical Trials;clinically relevant;Code;Cognition;Combined Modality Therapy;Community Practice;comorbidity;comparative effectiveness;comparative effectiveness study;compare effectiveness;Complex;Consensus;Data;data quality;Data Science;Data Set;Databases;Demographic Factors;Diabetes Mellitus;Diagnosis;Diagnostic;Diagnostic tests;disability;Dose;Early treatment;effective therapy;Effectiveness;effectiveness testing;Electronic Health Record;Emergency department visit;Equilibrium;Evidence based practice;first episode psychosis;Functional impairment;Goals;health data;hospital readmission;Hospitals;Impairment;improved;Incidence;Individual;individualized medicine;Informatics;information model;innovation;International;K-Series Research Career Programs;Knowledge;Laboratories;learning strategy;Machine Learning;machine learning algorithm;machine learning method;Medicaid;Medical;Mental Depression;Mental disorders;Methods;Modeling;network informatics;New York;novel;Outcome;outcome prediction;Patient-Focused Outcomes;Patients;Pattern;person centered;personalized medicine;Pharmaceutical Preparations;Pharmacoepidemiology;Population;Precision therapeutics;predict clinical outcome;Presbyterian Church;Procedures;psychiatric emergency;Psychiatry;psychosocial;psychotic symptoms;Randomized;randomized, clinical trials;Records;reduce symptoms;Regimen;Relapse;Research;Research Design;residence;response;Sampling;Schizophrenia;Scoring Method;Services;sex;social;societal costs;Specific qualifier value;Standardization;supervised learning;Symptoms;Techniques;Testing;Time;tool;Training;Translating;treatment effect;Treatment Effectiveness;treatment guidelines;Treatment Protocols;unsupervised learning

PROJECT_TITLE: Machine Learning for Precision Treatments in Schizophrenia


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative Tobacco use continue to pose significant public health concerns in the U.S. State states laws (preemption laws), prevent local communities from implementing policies to address these health behaviors. The proposed study will assess the effects of preemptive laws on tobacco and e-cigarette use.

PI_NAMEs: AZAGBA, SUNDAY  (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, ANNETTE R

PROJECT_TERMS: Address;Adolescent Risk Behavior;Adoption;Adult;Advertising;Affect;American;American Medical Association;Area;authority;Behavioral Risk Factor Surveillance System;catalyst;Cessation of life;Chronic Obstructive Pulmonary Disease;cigarette smoking;Code;Communities;County;Data Set;Databases;Decision Making;Dimensions;Disease;diverse data;Drug usage;Electronic cigarette;electronic cigarette use;Ethnic Origin;evidence base;experience;Foundations;Future;Gender;Government;Health;Health behavior;Health Policy;Healthy People 2020;Individual;indoor air;innovation;Institute of Medicine (U.S.);Knowledge;Laws;Legal;Licensure;Malignant neoplasm of lung;Measures;National Health Interview Survey;non-smoker;Outcome;Persons;Policies;Population;preempt;prevent;preventable death;Public Health;Public Policy;Quasi-experiment;Race;Reproducibility;Research;restraint;Rights;Rural Community;Rural Population;Smoke;smoke-free policy;Smoking;Smoking Behavior;Subgroup;substance abuse epidemiology;Surveys;System;Tobacco;tobacco control;Tobacco use;trend;Urban Community;Urban Population;Youth

PROJECT_TITLE: Assessing the Impact of State Preemption Laws

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE This proposed MorPhiC Data Analysis and Validation Center will utilize the innovative methods our team has developed (V2G2P, BPNet, DeepLift, monocle2/3, scribe, dynamo, spateo) to integrate multi-layer CRISPR, single-cell, imaging, and human genetics data. Together with the MorPhiC Consortium, our study will enable building a Catalog of Cellular Programs across cell types, ensure the robustness and interoperability of MorPhiC data, demonstrate its utility in identifying pathways for human diseases, and plan for an expansion of the MorPhiC project to study all human genes.

PI_NAMEs: ENGREITZ, JESSE M (contact);KUNDAJE, ANSHUL

PROGRAM_OFFICER_NAME: GAO, JEAN XUEJING

PROJECT_TERMS: Address;Biological;Biological Assay;Biology;Catalogs;causal variant;Cell Communication;cell type;Cells;Cellular Morphology;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;computational suite;Computer Models;computerized tools;Computing Methodologies;CRISPR interference;Data;Data Analyses;data modalities;data quality;Data Set;Disease;DNA Sequence;Ensure;experience;Experimental Designs;Gene Expression;gene network;gene regulatory network;Genes;Genetic;Genetic Diseases;Genetic Transcription;Genome;genome-wide analysis;genomic locus;Genomics;Goals;Human;human disease;Human Genetics;Image;imaging genetics;improved;innovation;insight;interdisciplinary collaboration;interoperability;Kinetics;Learning;Link;Maps;method development;Methods;Modeling;Molecular;multimodality;novel;Pathway interactions;Phase;Phenotype;Production;programs;reconstruction;Research Design;Research Personnel;Resources;RNA;RNA analysis;technology development;Thinking;tool;Validation;Variant;Work;XCL1 gene

PROJECT_TITLE: MorPhiC: Constructing a Catalog of Cellular Programs to Identify and Annotate Human Disease Genes


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Understanding whether cardiovascular devices are safe and effective for different groups of patients is an important public health and clinical concern. The overall goal of this proposal is to evaluate how the large amounts of data collected each day in the routine course of clinical care can best be used to study commonly used devices to treat serious heart conditions. The study will use state-of-the-science approaches for data analysis to examine whether several high-risk cardiovascular devices are being used safely and effectively in the United States today, including among patient subpopulations that are rarely included in clinical trials. The results of this research will determine how ubiquitous data collected by registries, health systems and payers, and advanced causal inference methods, can best be combined to improve our present and future understanding of new medical devices.

PI_NAMEs: DAHABREH, ISSA J.;YEH, ROBERT  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: abdominal aorta;analytical method;Benchmarking;black patient;Boston;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Caring;Cerebrum;Clinical;clinical care;clinical practice;Clinical Trials;clinically relevant;Communities;Community Practice;Complement;Data;Data Analyses;data registry;data resource;Data Set;design;Device Approval;Device Safety;Devices;Dimensions;Effectiveness;Elderly;Electronic Health Record;Eligibility Determination;Ethics;Evaluation;follow-up;Future;Goals;health goals;Health system;Healthcare Systems;Heart;Heart Valves;high risk;improved;innovation;Institution;instrument;Link;Massachusetts;mechanical circulatory support;Medical;Medical Device;Methodology;Methods;Mitral Valve;Morbidity - disease rate;mortality;neighborhood disadvantage;novel;Observational Study;Outcome;Patient Care;patient population;Patient Representative;patient subsets;Patient-Centered Care;Patients;Physicians;Population;post-market;programs;Provider;provider adoption;Public Health;Quasi-experiment;randomized trial;Registries;repaired;Research;Research Design;response;Risk;Safety;Sample Size;Science;Selection Bias;social disparities;Stents;Target Populations;Time;tool;treatment effect;trial design;United States;Variant;Woman;Work

PROJECT_TITLE: Use of Registries, Claims and Health System Data to Enhance the Evaluation of Cardiovascular Devices

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Nutrition;Obesity

ORG_CITY: DALLAS

ORG_DEPT: PEDIATRICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative The aim of the proposed research project is to determine how the HDL receptor SR-BI in adipocytes regulates the process by which high-fat diet feeding induces lipid accumulation in adipose tissue. We anticipate that the new knowledge gained will deepen our understanding of adipocyte biology through investigation of a novel, previously unappreciated role of HDL- cholesterol and its receptor SR-BI. Considering the staggering impact of obesity on metabolic and cardiovascular diseases, the goal of the research project is in line with the objectives of the National Institute of Health to address these disorders through medical research.

PI_NAMEs: MINEO, CHIEKO  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Address;adipocyte biology;Adipocytes;Adipose tissue;Affinity;ATAC-seq;Binding;Binding Sites;Cardiovascular Diseases;Caveolae;Cell membrane;Cell Size;Cholesterol;Cholesterol Homeostasis;Chromosome 12;cohort;combat;CRISPR/Cas technology;Data;deep learning algorithm;Disease;Distal;Electron Microscopy;Enhancers;Enzymes;experimental study;Fatty acid glycerol esters;feeding;Gene Expression Regulation;Genes;Genetic;Genetic Predisposition to Disease;Genetic Transcription;genome wide association study;Goals;Hepatocyte;Hi-C;High Density Lipoprotein Cholesterol;high density lipoprotein receptor;High Density Lipoproteins;High Fat Diet;Homeostasis;Human;in vivo;Intervention;Investigation;knock-down;Knowledge;Ligands;lipid metabolism;Lipids;Lipoproteins;Liver X Receptor;LoxP-flanked allele;Macrophage;Maintenance;Mediating;Medical Research;Membrane Microdomains;Metabolic Diseases;mouse model;Mus;Mutagenesis;mutant;Nonesterified Fatty Acids;novel;Obesity;obesity development;obesity risk;Phenotype;Play;Process;promoter;Regulation;Research Project Grants;Role;SR-BI receptor;steroid hormone;Sterols;Structure;Testing;Text;Tissues;transcription factor;Transcriptional Regulation;Triglycerides;United States National Institutes of Health;Up-Regulation;uptake;Wild Type Mouse

PROJECT_TITLE: A novel role of cholesterol and SR-BI in adipocyte biology

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The goal of this application is to support Dr. Singer's efforts and career development as a mentor to early career researchers through both individualized training and a cohort focused training program. She will develop the diabetes and obesity focused investigator pipeline with directed mentoring in her laboratory-based research focusing on sex differences in meta-inflammation and studies of meta-inflammatory monocytes in adolescent insulin resistance. The impact of this mentoring plan is broadened by bringing focused training on diversity, equity and inclusion, leadership and career development, and peer mentorship to cohorts of graduate and post-doctoral trainees in diabetes, obesity and metabolism research to build networks that support future leaders in the field.

PI_NAMEs: SINGER, KANAKADURGA  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Adipose tissue;Adolescent;Adult;American;Androgens;Area;Automobile Driving;Award;career;career development;Caring;Childhood;Chronic;clinical care;Clinical Endocrinology;cohort;Communities;Development;Diabetes Mellitus;diabetes risk;Diet;diet-induced obesity;disorder prevention;disorder risk;doctoral student;Educational Curriculum;Endocrine;Equity;equity, diversity, and inclusion;experience;Faculty;Focus Groups;Funding;Funding Agency;Future;Goals;graduate student;Grant;Hematopoietic;Heterogeneity;High Fat Diet;Immune response;improved;Individual;Inflammation;Inflammatory;Institution;Insulin Resistance;interest;Journals;Laboratories;Leadership;leadership development;Learning;learning community;Life;Mediation;meetings;Mentors;Mentorship;Metabolic Diseases;Metabolism;Michigan;monocyte;Myelogenous;National Institute of Diabetes and Digestive and Kidney Diseases;nutrition;Obesity;peer;Peer Group;personalized strategies;Positioning Attribute;Postdoctoral Fellow;prevent;programs;prospective;recruit;Research;Research Personnel;Research Support;response;Risk;Risk Factors;Risk Management;Role;Science;Scientist;Sex Differences;skills;Societies;Students;support network;Targeted Research;Teacher Professional Development;Training;Training Programs;unconscious bias;undergraduate student;Underrepresented Populations;Universities;Woman;Work

PROJECT_TITLE: Creating diverse communities in support of diabetes and metabolism research


ADMINISTERING_IC: FD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE  This proposal aims to determine the appropriate factors to scale the modified-release tablet formulation for additional strengths, and to identify the critical quality attributes and formulation design spaces for oral modified-release tablets with different formulation design strategies. Filling these knowledge gaps will facilitate the development of complex generic oral modified-release tablets. This will ultimately help enhance the public access to high quality and cost-effective complex oral modified-release drug products.

PI_NAMEs: SHEN, JIE  (contact)

PROGRAM_OFFICER_NAME: SUN, WEI-JHE

PROJECT_TITLE: Evaluation of Oral Modified-Release Tablets to Support the Approval of Additional Strengths


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Breast Cancer;Cancer;Substance Misuse;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Chronic alcohol consumption is linked with an increased risk of breast cancer development and progression in women. We have found that ethanol administration causes changes in the phosphorylation status of StarD10, an essential lipid transporter, and it is associated with altered cell growth and malignancy. Our proposal aims to investigate how phospho StarD10 modifications under alcohol abuse can be controlled and may provide a therapeutic target for alcohol-induce breast cancer progression.

PI_NAMEs: TOMASI, MARIA LAUDA (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Alcohol abuse;Alcohol consumption;alcohol exposure;alcohol response;Alcohols;beta Karyopherins;Binding;Biological;Biological Process;Breast;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;breast cancer progression;Breast Cancer Risk Factor;Breast Cancer therapy;Breast Cancer Treatment;Breast Feeding;cancer cell;casein kinase I;cell growth;Cell membrane;cell motility;Cell Nucleus;Cell Proliferation;Cell Survival;Cells;chronic alcohol ingestion;Complex;CRISPR/Cas technology;crosslink;Data;Development;DNA Damage;Endoplasmic Reticulum;Epithelium;ERBB2 gene;Estrogens;Ethanol;Exhibits;experimental study;Family member;Gene Expression Regulation;Genes;Growth;Homeostasis;Hormones;Human;In Vitro;in vivo;Invaded;Knowledge;Lecithin;Link;lipid transfer protein;Lipids;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mammary Tumorigenesis;Membrane;Membrane Fluidity;Mesenchymal;migration;Modification;Mouse Mammary Tumor Virus;mouse model;Mutate;new therapeutic target;novel;Nuclear Import;Nuclear Translocation;Organoids;overexpression;p65;Pathway interactions;Patients;Peptide Mapping;Phosphatidylethanolamine;Phosphatidylinositol Phosphates;Phosphoric Monoester Hydrolases;Phosphorylation;Play;precise genome editing;prevent;Process;Prognosis;Proliferating;Protein Dephosphorylation;Protein phosphatase;Protein Tyrosine Kinase;Proteins;Proteomics;Public Health;receptor;receptor expression;receptor function;Receptor Protein-Tyrosine Kinases;Recurrence;Regulation;Relapse;Reporting;Research;Risk;Role;Second Messenger Systems;Signal Transduction;symporter;targeted treatment;Testing;Therapeutic;therapeutic target;Threonine;trafficking;transcription factor;Transgenic Mice;Transplantation;tumorigenesis;Tyrosine;Woman;Work

PROJECT_TITLE: Role of StAR-related lipid transfer protein 10 in alcohol-induced breast cancer progression

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Cardiovascular;Endocannabinoid System Research;Epilepsy;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The proposed research is relevant to public health because it focuses on investigating a specific mechanism that may contribute to increased seizure sensitivity in eclampsia, a condition in which pregnant women have novel spontaneous seizures. By identifying whether the endocannabinoid system is disrupted in our preclinical model of eclampsia, there is potential for development of novel therapeutic targets for reducing seizure severity in pregnant women and women with preeclampsia/eclampsia. The proposed research is relevant to the part of the NIH’s mission that pertains to reducing illness and disability.

PI_NAMEs: JONES-MUHAMMAD, MARIA AISHA (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Adolescence;adolescent offspring;Adult;Affect;Agonist;anandamide;antagonist;Behavior;Binding;Brain;Cannabinoids;career;career development;clinically relevant;CNR1 gene;Consensus;Data;Development;disability;Eclampsia;Electroencephalography;Electrophysiology (science);Endocannabinoids;Endocrinology;endogenous cannabinoid system;Enzymes;Epilepsy;Epileptogenesis;excitatory neuron;Exhibits;Exposure to;Female;fetal;Fetal Development;fetal marijuana exposure;Goals;Grant;High Pressure Liquid Chromatography;Hippocampus;Hypertension;Immunofluorescence Immunologic;Impairment;in utero;infancy;inhibitory neuron;innovation;insight;Institution;interest;Interview;Investigation;Ligands;male;Manuscripts;Mass Spectrum Analysis;maternal marijuana use;Maternal Mortality;Measures;Mentors;Mission;Modeling;Morbidity - disease rate;mortality;Mothers;Mus;neurodevelopment;Neurodevelopmental Disorder;Neurons;Neurosciences Research;new therapeutic target;novel;offspring;Patients;Pentylenetetrazole;Perfusion;Phase;Play;post-doctoral training;Postdoctoral Fellow;Postpartum Period;Pre-Clinical Model;Pre-Eclampsia;Predisposition;Pregnancy;pregnancy disorder;Pregnant Women;pressure;prevent;programs;Public Health;Publications;Rattus;Research;research and development;Research Project Grants;rimonabant;Rodent;Role;Scientist;Seizures;Severities;sex;Sex Differences;sham surgery;skills;Social Behavior;Stains;success;Testing;therapeutic target;timeline;tissue processing;Training;United States National Institutes of Health;Uterus;Western Blotting;Woman;Work

PROJECT_TITLE: Sex-specific development of seizure activity following endocannabinoid system manipulation in the fetal brain


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: The proposed work takes a multidisciplinary approach to studying the retrosplenial cortex and the subiculum, both of  which are important for memory. The retrosplenial cortex is one of the first areas to be affected by Alzheimer’s  disease, and topological disorientation is one of the first symptoms. Greater knowledge of retrosplenial cortex and  subiculum function will help determine earlier identification of those at risk for these disorders.

PI_NAMEs: CHRASTIL, ELIZABETH ;KRICHMAR, JEFFREY L (contact);NITZ, DOUGLAS ARTHUR

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Architecture;Area;Artificial Intelligence;Back;Behavior;Behavioral;Biological;Brain imaging;Cells;Cognitive;cognitive function;cognitive task;Computer Models;Cues;Data;Decision Making;disorder risk;Disorientation;Early identification;Environment;experience;Experimental Designs;experimental study;flexibility;Goals;Human;interdisciplinary approach;interest;Knowledge;Learning;Link;Location;Machine Learning;Maps;Memory;memory recall;Modeling;multidisciplinary;neural;Neural Network Simulation;Neurons;neurophysiology;Organism;Paper;Persons;perspective taking;Play;Rattus;Reporting;Research;Research Proposals;Rodent;simulation;Stream;Symptoms;System;Testing;Translating;Work

PROJECT_TITLE: CRCNS: There and Back Again Linking Global Maps to First-Person Perspectives

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(50)R]


ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This proposal describes a comprehensive approach to systemically deliver small molecule immunomodulators for improving the therapeutic index of combination cancer immunotherapy. The key objective is to develop these therapies using safe prodrug linkers, precise sizes and dosing schedules tuned to circumvent tolerance, which will improve the ability of these drugs to induce a potent and selective immune response. This work will focus formulation design efforts and dosing schemes to advance anti-cancer immunotherapy platforms into the clinic sooner.

PI_NAMEs: BHAGCHANDANI, SACHIN  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acceleration;Agonist;anti-CTLA4;anti-PD1 antibodies;anti-tumor immune response;appropriate dose;Architecture;Autoimmunity;Biodistribution;Blood;cancer cell;cancer immunotherapy;Cancer Patient;cancer therapy;Cells;Chemistry;Clinic;Clinical;clinical practice;Clinical Trials;Combination immunotherapy;Cream;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;design;Development;Disease;disease model;Disseminated Malignant Neoplasm;Dose;Drug Delivery Systems;Drug Kinetics;effective therapy;efficacy evaluation;Endosomes;Equilibrium;Evaluation;experimental study;Failure;Formulation;Functional disorder;Gel;Genetically Engineered Mouse;Goals;Grant;Human;Imiquimod;Immune;immune checkpoint blockade;immune modulating agents;Immune response;Immune system;Immune Tolerance;immune-related adverse events;Immunity;Immunologic Stimulation;Immunomodulators;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;in vitro Assay;in vivo;insight;Investigation;Kinetics;Lesion;Ligands;Malignant Neoplasms;Melanoma;Metastatic Melanoma;Molecular;mouse model;Pathway interactions;patient subsets;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Polymers;Population;Postdoctoral Fellow;pre-clinical;Primary Neoplasm;Prodrugs;Progression-Free Survivals;Property;Ramp;rational design;Receptor Activation;Refractory;Reporter;Research;Research Project Grants;resiquimod;response;Safety;Schedule;Scheme;Site;small molecule;T-Lymphocyte;Technical Expertise;Therapeutic;Therapeutic Index;therapy development;time interval;TLR7 gene;Toll-like receptors;Topical application;Toxic effect;Translating;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;uptake;Work

PROJECT_TITLE: Toward safe, systemic immunotherapies for treatment of metastatic disease: Developing dendritic cell-biased immunomodulators with precise control over magnitude and timing of immune stimulation


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Sleep Research

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: The proposed research is relevant to public health because obstructive sleep apnea is a disorder of repeated upper airway obstruction during sleep that is associated with substantial cardiovascular morbidity and mortality, daytime somnolence, and decreased quality of life and because available treatments have important limitations. For patients who do not tolerate positive airway pressure therapy, alternative treatment options include surgery, which often improves but may not eliminate obstructive sleep apnea; studies suggest that two reasons for limited surgery outcomes are an abnormal control of breathing (elevated loop gain) and increased tendency to awaken from sleep (decreased arousal threshold). Our strategy is to understand the mechanisms explaining surgery success/failure as well as results of increasing loop gain with acetazolamide and raising arousal threshold with eszopiclone.

PI_NAMEs: KEZIRIAN, ERIC JAMES (contact)

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: Acetazolamide;Address;Air Movements;airway obstruction;Algorithms;alternative treatment;Anatomy;Apnea;Arousal;Breathing;Cardiovascular system;Cross-Over Studies;Dilator;Disease;Drowsiness;Effectiveness;efficacy evaluation;Endoscopy;Eszopiclone;Evaluation;experience;Failure;Functional disorder;Goals;improved;indexing;innovation;Intervention;Investigation;Measurement;Measures;Morbidity - disease rate;mortality;Multiple Abnormalities;Muscle;Neurocognitive;novel therapeutics;Obstruction;Obstructive Sleep Apnea;Operative Surgical Procedures;Palate;Participant;Patients;Pattern;Pharmaceutical Preparations;Polysomnography;Positioning Attribute;positive airway pressure;Postoperative Period;pressure;Procedures;Prospective cohort;Public Health;Quality of life;Randomized;Research;Resolution;response;Sedation procedure;Severities;shape analysis;Shapes;signal processing;Sleep;Soft Palate;Source;success;surgery outcome;Therapeutic;Tissues;trait;Treatment Efficacy;ventilation

PROJECT_TITLE: Upper airway collapsibility, loop gain and arousal threshold: an integrative therapeutic approach to obstructive sleep apnea

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Pediatric

ORG_CITY: WALTHAM

ORG_DEPT: MISCELLANEOUS

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Body symmetry is crucial for physiological posture and function. A prominent example of  developmental failure in symmetry maintenance is fetal hemivertebrae, a rare congenital malformation  that affects 5-10 in 10,000 births, resulting in spinal deformation such as scoliosis. This project will  contribute to understanding the developmental origin of such body symmetry/asymmetry issues, and  this improved understanding could lead, at term, to new medical treatments or preventive measures.

PI_NAMEs: TOUBOUL, JONATHAN DAVID (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Affect;Anatomy;Animals;Biological;Birth;Breathing;Buffers;Cilia;Congenital Abnormality;Coupled;Data;Data Analyses;Development;Diffusion;Embryo;Embryonic Development;Embryonic Structures;Exhibits;experimental study;Failure;fetal;Gene Expression;Genetic study;Image;Imaging Techniques;Impairment;improved;insight;Lead;Left;Liquid substance;Maintenance;mathematical model;Mediating;Medical;Modeling;Molecular;Movement;Mus;Paraxial Mesoderm;Phase;Physiological;Positioning Attribute;Posture;Preventive measure;Reaction;Research Design;rib bone structure;scoliosis;Segmentation Clock Pathway;Side;Signal Transduction;Signaling Molecule;simulation;Somites;somitogenesis;spatiotemporal;Specific qualifier value;Spinal;spine bone structure;System;Theoretical model;Tretinoin;Vertebrates;Wild Type Mouse

PROJECT_TITLE: Dynamical maintenance of left-right symmetry during vertebrate development


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Cardiovascular;Contraception/Reproduction;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pregnancy;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE High blood sugar (diabetes) is a common metabolic problem that causes major complications in pregnancy. The goal of this proposal is to support high-quality mentorship of graduate students and postdoctoral fellows from underrepresented backgrounds in diabetes and pregnancy investigation. This training is expected to prepare a new generation of researchers to improve metabolic health during pregnancy and lactation.

PI_NAMEs: POWE, CAMILLE ELISE (contact)

PROJECT_TERMS: Address;Affect;Award;Biomedical Research;Black race;Blood Glucose;Boston;cardiometabolic risk;cardiovascular risk factor;career;Caring;Cell Cycle Kinetics;Child;Clinical Research;cohort;Collaborations;Continuous Glucose Monitor;Data;Data Set;design;Diabetes Mellitus;diabetes risk;Diagnosis;Discipline of obstetrics;Disease;early pregnancy;Endocrinologist;Environment;Erythrocytes;Event;Exclusion;Faculty;Fellowship;Fetal Growth;Functional disorder;Funding;Future;General Hospitals;Generations;genetic architecture;genetic profiling;Gestational Diabetes;Glycosylated hemoglobin A;Goals;graduate student;Grant;Health;Home;Hour;Hyperglycemia;Hypertension;improved;Individual;innovation;Institution;Insulin;Investigation;K-Series Research Career Programs;Knowledge;Lactation;marginalized population;Massachusetts;medical schools;Mentors;Mentorship;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Minority Groups;minority investigator;Modeling;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;neonatal morbidity;novel;novel strategies;patient oriented;Persons;Physicians;Physiological;Population;Postdoctoral Fellow;Pregnancy;Pregnancy Complications;pregnancy disorder;Pregnancy in Diabetics;Pregnancy Outcome;pregnant;Premature Birth;Principal Investigator;Professional Organizations;programs;recruit;Research;Research Personnel;Research Project Grants;research study;Research Support;Research Training;Resources;Scientist;System;Techniques;Technology;Therapeutic;Training;Training Programs;Underrepresented Populations;United States National Institutes of Health;Weight

PROJECT_TITLE: Mentoring Underrepresented Researchers in Diabetes and Pregnancy Investigation


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Women's Health Research

ORG_DEPT: PHYSIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Dominant-negative mutations in the membrane transport gene SLC4A11 cause a progressive vision loss called Fuchs Corneal Endothelial Dystrophy (FECD). We have introduced such a mutation into a transgenic mouse with the goal of understanding how genetic and extrinsic factors combine to influence the progression of the disease and why these mutations are dominant. This mouse model, the first genetic model of late- onset FECD, will be a useful tool for developing and testing novel therapies.

PI_NAMEs: PARKER, MARK  (contact)

PROJECT_TERMS: Acids;Address;Animal Model;Antioxidants;Area;base;Blindness;Cell Culture Techniques;Cell Physiology;Cellular biology;Cellular Stress;Clinical;Complex;Cornea;Corneal Diseases;Corneal dystrophy;Corneal edema;Corneal Endothelium;Corneal Stroma;Cysteine;Deposition;Descemet's membrane;Development;Diabetes Mellitus;Diagnostic;Diclofenac;Disease;Disease Progression;Disproportionately impacts women;dominant genetic mutation;Dominant-Negative Mutation;Edema;Endothelial Cells;Endothelium;Etiology;Event;Exhibits;Exposure to;Failure;Fuchs' Endothelial Dystrophy;Functional disorder;Genes;Genetic;Genetic Diseases;Genetic Models;Genotype;Goals;Grouping;Health;Heterozygote;Homozygote;Human;Hydration status;in vivo evaluation;Inherited;innovation;interdisciplinary approach;Keratoplasty;Knockout Mice;life span;Link;Liquid substance;Membrane Transport Proteins;Modeling;Molecular;Monitor;mouse model;Mus;mutant;Mutation;Nature;novel;novel marker;novel therapeutics;null mutation;Older Population;Onset of illness;oxidative damage;Oxidative Stress;Penetrance;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;pre-clinical;Predisposition;prevent;Production;Proteins;Pump;Research;Risk;Role;Scientist;Sex Bias;Smoking;Strategic Planning;Sunlight;Swelling;synergism;System;Testing;Therapeutic;Therapeutic Intervention;tool;transcriptome;transcriptomics;Transgenic Mice;Transmembrane Transport;Transplantation;Ultraviolet A radiation;Untranslated RNA;Wild Type Mouse

PROJECT_TITLE: Investigating the Action and Physiological Role of Slc4a11 in the Cornea

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Systematic risk assessment in primary care populations is critical to identifying those at increased risk of disease and initiating appropriate preventive care. Currently a high proportion of high risk patients (25%) are going undetected due to barriers affecting both patients and providers. This proposal seeks to address this problem by developing and end to end solution for a family health history based genomic risk assessment model that will meet the needs of diverse populations.

PI_NAMEs: ORLANDO, LORI ANN (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Address;Affect;Algorithms;Caring;cascade genetic testing;Caucasians;Characteristics;Clinical;clinical care;clinical decision support;clinical decision-making;clinical research site;Complex;cost;cost effectiveness;Counseling;Data;Data Collection;data platform;data standards;design;Development;Disease Management;disorder risk;Disparity;disparity gap;Education;effectiveness outcome;effectiveness/implementation trial;electronic medical record system;evidence base;evidence based guidelines;Family;Family health status;Family member;Frequencies;Funding;General Population;Genetic Counseling;genetic testing;Genomic medicine;Genomics;Goals;Guidelines;health disparity;Health system;Healthcare Systems;hereditary risk;high risk;Hybrids;implementation evaluation;implementation framework;implementation outcomes;implementation science;implementation/effectiveness;improved;Individual;Inherited;Learning;literacy;meetings;Minority;Minority Groups;Modeling;Online Systems;Outcome;Participant;Pathway interactions;Patient Care;Patient Care Planning;patient population;Patient risk;Patient-Focused Outcomes;Patients;Population;population health;Population Heterogeneity;pragmatic implementation;Preventive care;Primary Care;primary care patient;primary care provider;primary care setting;programs;Provider;Quality of life;Randomized;Recording of previous events;Reduce health disparities;Resource-limited setting;Resources;Risk;Risk Assessment;Risk Management;risk sharing;routine care;Service delivery model;Social Network;Syndrome;System;Technology;Test Result;Testing;Time;tool;Underserved Population;United States National Institutes of Health;uptake;Work

PROJECT_TITLE: Deploying a genomic-medicine risk assessment model for diverse primary care populations and settings


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Endocrine Disruptors;Estrogen;Osteoporosis;Pediatric;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Achieving optimal bone accrual and strength in adolescence reduces risk of fractures and osteoporosis throughout life. Bone health may be affected by exposure to endocrine disrupting chemicals commonly found in consumer products. We will investigate the impact of these chemicals on bone strength and fractures in adolescence with the aim of identifying new ways to optimize lifelong bone health.

PI_NAMEs: BUCKLEY, JESSIE P (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: 12 year old;17 year old;3-Dimensional;Adolescence;Adolescent;Adult;Affect;Age;American;Animals;Anthropometry;Back;Biological Markers;Biostatistical Methods;Birth;Blood;bone;Bone Density;Bone Diseases;bone geometry;bone health;bone imaging;bone mass;bone strength;bone turnover;chemical association;Chemical Exposure;Chemicals;Child;Childhood;Chronic;Clinic;Clinical;clinically significant;Cohort Studies;consumer product;critical period;Cross-Sectional Studies;Data;design;Development;Diet;Dual-Energy X-Ray Absorptiometry;early adolescence;early childhood;emerging adult;Endocrine;Endocrine Disruptors;Enrollment;Environment;Environmental Exposure;Epidemiology;Esters;Evaluation;Exposure to;Flame Retardants;follow-up;Forearm;Fracture;fracture risk;Future;Geometry;Goals;Health;Homeostasis;Human;indexing;Individual;innovation;Intervention;Laboratory Study;Life;Longitudinal cohort study;male;Measures;modifiable risk;Morphology;Mothers;Ohio;older adult;Organophosphates;Osteoporosis;Outcome;Participant;Peripheral;phthalates;Physical activity;Physiologic calcification;Poly-fluoroalkyl substances;Population;Predisposition;Pregnancy;Process;prospective;Prospective Studies;Puberty;Public Health;Radial;Recording of previous events;Risk;Risk Factors;Risk Reduction;sex;Site;skeletal;Techniques;tool;two-dimensional;Urine;Visit;Work;X-Ray Computed Tomography

PROJECT_TITLE: Endocrine disrupting chemical mixtures and bone health in adolescence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(02)]


NIH_SPENDING_CATS: Natural Products

ORG_CITY: CHAMPAIGN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Polyether natural products hold tremendous therapeutic potential as they possess antibacterial, antifungal, immunosuppressive, and antiproliferative activities. Our work will greatly enhance our understanding of how living organisms synthesize these important molecules. It is essential that we comprehend how nature produces polyethers because it will enable rational engineering of biosynthetic enzymes and biosynthesis pathways for production of novel polyethers for drug development.

PI_NAMEs: KIM, CHU-YOUNG  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acyl Carrier Protein;Acyltransferase;Anabolism;Anti-Bacterial Agents;anti-cancer;anti-fungal agents;Antibiotics;Bacteria;Binding;Biochemical;Biogenesis;Biological Models;Chemicals;Complex;Cyclic Ethers;Cyclization;Development;dimer;Docking;drug development;Engineering;Ensure;Enzymes;Epoxide hydrolase;Epoxy Compounds;Family;Flavins;Foundations;Friends;Future;Gene Cluster;Goals;Investigation;Laboratories;Mixed Function Oxygenases;Molecular;Molecular Conformation;Natural Products;Nature;novel;novel therapeutics;Organism;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;Polyenes;polyketide synthase;polyketides;Production;programs;Property;protein protein interaction;Reaction;Research;Scheme;seal;Solid;Streptomyces;structural biology;Structure;Subgroup;Techniques;Testing;Therapeutic;Time;Vertebral column;Work;Yeasts

PROJECT_TITLE: Structural biology of polyether antibiotic biosynthesis

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Bowel resection leads to Short Bowel Syndrome (SBS), a devastating condition resulting from inadequate remaining intestines to sustain nutritional needs though enteral feeding, and thus worldwide, tens of thousands of such patients require intravenous nutrition support via a process called Total Parenteral Nutrition, many with lifelong dependence. However, SBS patients suffer from side effects of potentially fatal liver and gut injury despite this lifesaving therapy. We have published novel findings of disrupted gut derived signals as a driver for injury in SBS and this project, using our highly translatable, novel ambulatory SBS piglet model, closely recapitulating human SBS, proposes to critically understand the altered gut signaling and test if its restoration in SBS would mitigate injury and advance our scientific knowledge with insights into mechanistic pathways.

PI_NAMEs: JAIN, AJAY K. (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Address;Agonist;Animal Model;Animals;Atrophic;Automobile Driving;Bile Acid Biosynthesis Pathway;Bile Acids;Blood Circulation;blood glucose regulation;Catheters;Chenodeoxycholic Acid;Cholestasis;Cholesterol 7-alpha-Monooxygenase;clinically relevant;Complication;CYP7A1 gene;Data;Dependence;deprivation;Dose;Duodenum;Dyslipidemias;Enteral;Enteral Feeding;Enteral Nutrition;Enterocytes;Enterohepatic Circulation;Etiology;Excision;Failure;Fatty Liver;FGF19 gene;Fibroblast Growth Factor Receptors;Gene Expression;GLP-2;glucagon-like peptide;glucagon-like peptide 1;Glucose;Glucose Intolerance;GPBAR1 gene;Hepatic;Histology;Hour;Human;Impairment;Inflammation;Injury;insight;Insulin;Intestinal permeability;Intestines;intrahepatic;Intravenous;Knowledge;Life;Link;Lipids;Liver;Liver diseases;liver injury;Modeling;novel;Nuclear Receptors;nutrition;Nutritional;Oleanolic Acid;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patients;Peptide Signal Sequences;Pilot Projects;porcine model;prevent;Prevention;Process;Proteins;Publishing;Pump;receptor;Receptor Activation;Repression;Research;Research Personnel;restoration;Rodent;Role;Schedule;Serology;Serum;Short Bowel Syndrome;side effect;Signal Pathway;Signal Transduction;Testing;Total Parenteral Nutrition;Treatment outcome

PROJECT_TITLE: Role of bile acid receptors FXR and TGR5 in preventing injury in short bowel syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Wound Healing and Care

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

PHR: PROJECT NARRATIVE Corneal scarring is a major cause of blindness in the world today but its epidemiology is proven to be very complicated and dependent on a variety of factors, including trauma, infections, and inflammation. Currently, and for the last four decades, the only available treatment for corneal scarring is corneal transplantation; however, this therapy has significant side effects and concerns. Through our studies, we have shown that PIP can blunt fibrosis both in vitro and in vivo, and therefore, we propose to extend, modify, and optimize our findings in order to develop a novel therapeutic agent that can help ameliorate corneal scarring.

PI_NAMEs: KARAMICHOS, DIMITRIOS  (contact);MA, JIAN-XING

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Acceleration;Affect;Apoptosis;Biological;Biological Markers;Blinded;Blindness;Blood;Cancerous breast;Cells;Cementation;Cicatrix;Clinic;Clinical;Collagen Type III;Cornea;Corneal Diseases;corneal epithelial wound healing;Corneal Injury;corneal scar;Corneal Stroma;cost;Data;Debridement;Deposition;Development;diagnostic biomarker;Disease;disease diagnosis;drug development;Drug Kinetics;effective therapy;efficacy evaluation;Epidemiology;Epithelium;Exposure to;Extracellular Matrix;Eyedrops;Fibronectins;Fibrosis;Foundations;Future;Goals;Health;Human;improved;In Vitro;in vitro Model;in vivo;Infection;Inflammation;Injections;Injury;Integrin alpha6;Integrin beta4;Investigation;Keratoconus;Keratoplasty;Link;Liquid substance;Maintenance;Malignant Breast Neoplasm;Mammary Gland Parenchyma;Measures;Metabolism;migration;Miniature Swine;Mitochondria;Modeling;Molecular;Monkeys;Mus;Myofibroblast;Names;novel;novel therapeutics;Operative Surgical Procedures;Patients;Persons;Pharmaceutical Preparations;polypeptide;prevent;Primates;Process;Prolactin;Proliferating;protein expression;Protein Isoforms;Proteins;Public Health;Publishing;Quality of life;Reporting;Role;Saliva;Seminal fluid;Shapes;side effect;Signal Transduction;Signaling Protein;Stromal Cells;Techniques;Therapeutic Agents;Therapeutic Intervention;therapeutic target;Thick;Thrombospondin 1;Time;Transforming Growth Factor beta;Trauma;United States Food and Drug Administration;Vision;wound;wound healing

PROJECT_TITLE: The Impact of Prolactin Induced Protein in Corneal Wound Healing and Fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Kidney Disease;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Urologic Diseases

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Renal gene therapy for monogenic diseases such as cystinuria would allow for new therapeutic options for previously difficult to treat conditions with significant morbidity and mortality. The barriers to renal gene therapy could be overcome with targeted delivery to proximal tubules using adeno-associated viruses (AAV) and stable integration of transgenes using transposons. Therefore, restoration of the pathogenically deficient cystine transporter using AAV delivery and transposon integration could prevent the stone-forming phenotype of cystinuria and provide new therapeutic opportunities for other monogenic renal diseases.

PI_NAMEs: PEEK, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: absorption;adeno-associated viral vector;adenovirus mediated delivery;Amino Acid Transporter;Amino Acids;cell immortalization;Cell Line;Cells;Chronic Kidney Failure;Clinical Treatment;CRISPR/Cas technology;curative treatments;Cystine;Cystinuria;Dependovirus;design;disease model;effective therapy;Embryo;Engineering;Epithelial Cells;Evaluation;Failure;Fibroblasts;gene therapy;gene-targeted therapy;Genes;Genetic Recombination;Genome;Genome engineering;Goals;Health;homologous recombination;Human;Hybrids;Immunofluorescence Immunologic;Immunohistochemistry;improved;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;Kidney;Kidney Diseases;Knock-out;Length;Life;live cell imaging;Longevity;mass spectrometric imaging;Mediating;Mendelian disorder;Messenger RNA;Modeling;Morbidity - disease rate;mortality;mouse genome;mouse model;Mus;Mutation;novel;novel therapeutics;Organoids;Paste substance;Pathogenicity;Patients;Phenotype;prevent;Prevention;Proximal Kidney Tubules;reconstitution;restoration;RNA Splicing;Specificity;Structure;System;targeted delivery;Testing;Tissue Harvesting;Transcript;transduction efficiency;transgene expression;Transgenes;urinary;Urinary Calculi;Urinary tract;vector;Work

PROJECT_TITLE: Proximal Tubule Targeted Gene Therapy for Cystinuria


NIH_SPENDING_CATS: Cancer;Dietary Supplements;Digestive Diseases;Nutrition;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: Project Narrative Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer that is associated with dysregulated tumor and whole-body metabolism that impacts therapy and quality of life. An opportunity for better exploiting metabolic vulnerabilities in PDAC for cancer treatment is to systematically examine how dietary interventions impact PDAC progression, therapy responses, and survival. This proposed research will elucidate the metabolic mechanisms underlying potential synergies between dietary factors and standard-of-care or emerging PDAC therapies in an effort to provide scientific evidence that can benefit patients with guidance on how to best incorporate diet and nutrition into PDAC treatment.

PI_NAMEs: LIEN, EVAN CHEN (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Affect;Anorexia;Antineoplastic Agents;Cachexia;Caloric Restriction;Cancer Biology;cancer cell;Cancer Model;Cancer Patient;cancer therapy;career development;Cell Death;Cell Signaling Process;Cells;chemotherapy;Circulation;Communication;Consumption;Dependence;Desire for food;Desmoplastic;Development;Development Plans;Diet;diet and cancer;Diet and Nutrition;Diet therapy;dietary;Dietary Factors;Dietary Fats;Dietary Intervention;Dietary Practices;Digestion;Drug Combinations;Drug Targeting;Educational process of instructing;Environment;enzyme replacement therapy;Epidemiology;Exocrine pancreatic insufficiency;Extracellular Matrix;Fatty acid glycerol esters;fatty acid metabolism;Food;food restriction;Foundations;Genes;Goals;Growth;Impairment;improved;in vivo;inhibitor;Intercellular Fluid;Learning;lipid metabolism;Lipid Peroxidation;lipidomics;Lipids;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mentors;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Molecular;mouse model;Mus;Nutrient;Nutrient availability;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pancreatic enzyme;Patient Care;Patients;Peripheral;Polyunsaturated Fatty Acids;Positioning Attribute;Quality of life;Recommendation;Reducing diet;Research;Research Personnel;Research Proposals;response;Science;Scientist;Shapes;skills;stable isotope;standard of care;Stromal Cells;Survival Rate;synergism;Technology;Testing;Therapeutic;Tissues;Trace Elements Nutrition;Training;transcriptome sequencing;Translations;Treatment Efficacy;treatment response;tumor;tumor growth;tumor metabolism;tumor microenvironment;tumor progression;wasting;Work

PROJECT_TITLE: Understanding the effects of dietary interventions on pancreatic ductal adenocarcinoma therapy cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Stroke;Unintentional Childhood Injury

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Neonatal hypoxic-ischemic encephalopathy (HIE) occurs in 3-4 per 1,000 live births in the USA and may cause grave consequences including cerebral palsy, epilepsy, and cognitive impairment, but the outcome prognostication and early detection of brain damage in these neonates remain challenges. In this project, we will use advanced imaging technology and biochemical methods to test whether the cerebral metabolic rate of oxygen (CMRO2) can serve as a bedside biomarker for HIE brain damage. Outcomes of this project will also shed insights into the mechanisms of therapeutic hypothermia and suggest novel treatments of HIE.

PI_NAMEs: HU, SONG ;KUAN, CHIA-YI  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Abate;Address;Adjuvant Therapy;Adult;Antioxidants;ATP Synthesis Pathway;Attenuated;awake;behavioral outcome;Binding;Biochemical;Biological Markers;Biopsy;Blood;Brain Hypoxia-Ischemia;Brain Injuries;brain tissue;candidate marker;Cerebral Ischemia-Hypoxia;Cerebral Palsy;Cerebrum;Clinical Management;Complex;Contralateral;cranium;Data;Detection;Early Diagnosis;Electron Transport;Epilepsy;exhaustion;experimental study;Failure;Foundations;Freezing;Glutamates;Glutamine;HIF1A gene;high risk;Histologic;Hyperactivity;hypoxic ischemic injury;Imaging technology;Impaired cognition;improved;Infarction;insight;Interruption;Ipsilateral;Ischemic Brain Injury;Ischemic Stroke;Knowledge;Live Birth;Magic;Magnetic Resonance Spectroscopy;Measurement;Measures;Membrane Potentials;metabolic rate;Metabolism;Methods;microscopic imaging;Microscopy;Mitochondria;Modeling;Monitor;mouse model;Mus;N-acetylaspartate;natural hypothermia;neonatal brain;Neonatal Brain Injury;neonatal hypoxic-ischemic brain injury;neonate;Neonatology;neuropathology;non-invasive monitor;novel;optical imaging;Optics;osteopontin;Outcome;outcome prediction;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;Pathologic;phenylmethylpyrazolone;Phosphocreatine;Phosphorylation;preservation;prevent;Prognostic Marker;prognostic value;prognostication;public health relevance;Reactive Oxygen Species;Recovery;Reperfusion Therapy;Respiration;Speed;stroke therapy;Superoxides;synergism;System;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Time;Tissue Viability;UCHL1 gene

PROJECT_TITLE: CMRO2 and Uncoupling of Oxidative-Phosphorylation in Experimental HIE

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Cancer;Genetics;Neurodegenerative;Rare Diseases

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Unstructured domains of a family of RNA-binding proteins form aggregates implicated in amyotrophic lateral sclerosis (also known as ALS or Lou Gehrig’s Disease) and make up cancer-causing domains in forms of leukemia and sarcoma. Determining the structural details of the RNA-binding protein Fused in Sarcoma and its assemblies is the first step to finding new therapies to prevent these difficult-to-treat diseases.

PI_NAMEs: FAWZI, NICOLAS LUX (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Amino Acids;Amyotrophic Lateral Sclerosis;Aromatic Amino Acids;Automobile Driving;beta pleated sheet;Binding;Biological;Biological Assay;Biological Models;Biological Process;Biophysics;C-terminal;Cations;cell behavior;Cell fusion;Cell model;Cell Physiology;Cells;Cellular Stress;Characteristics;Charge;Chimeric Proteins;Chromosomal translocation;Complex;Computer Simulation;Cytoplasmic Granules;Data;Disease;DNA Binding Domain;DNA Damage;DNA Polymerase II;DNA Repair;effective therapy;Explosion;familial amyotrophic lateral sclerosis;Family;Foundations;Frequencies;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;fused in sarcoma;Future;Gene Expression;Genetic Transcription;Goals;Human;In Vitro;in vivo;insight;Knowledge;Lead;leukemia;Link;Liquid substance;Malignant Neoplasms;Mediating;Membrane;Missense Mutation;Modeling;Modification;Molecular;Molecular Probes;multimodality;Mutation;Neurodegenerative Disorders;Neurons;NMR Spectroscopy;novel therapeutics;Nuclear Localization Signal;Oncogenic;Organelles;paralogous gene;Pathologic;Pattern;pharmacologic;Phase;Physiological;Physiology;Play;Post-Translational Protein Processing;prevent;Process;protein structure;Proteins;Resolution;response;RNA;RNA Folding;RNA metabolism;RNA Polymerase II;RNA Processing;RNA Recognition Motif;RNA Splicing;RNA-Binding Proteins;Role;Sarcoma;Signal Induction;simulation;structural biology;Structure;TAF15 gene;Techniques;Testing;Transcription Coactivator;transcription factor;Transcriptional Activation;Untranslated RNA;Visualization;Work

PROJECT_TITLE: Residue-by-residue details of FUS protein phase separation and aggregation

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Lung;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Acute Respiratory Distress Syndrome (ARDS) is a common, often fatal lung condition for which there are few effective treatments. Use of a mechanical ventilator is critical for survival; however, the ventilator may also cause lung damage and increase risk of death in patients with ARDS. This research evaluates a new approach to mechanical ventilation using the Driving Pressure as a target for lung-protective ventilation, with the ultimate goal of minimizing lung damage and improving survival for ARDS patients.

PI_NAMEs: SAHETYA, SARINA  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Acute respiratory failure;Adverse event;Affect;Area;Automobile Driving;Award;Biometry;career;career development;Characteristics;Chest wall structure;Clinical;clinical care;clinical investigation;Comparison arm;Conduct Clinical Trials;COVID-19 pandemic;Critical Care;Data;Databases;design;Development Plans;Dropout;effective therapy;efficacy evaluation;Enrollment;Ensure;Environment;experience;Exposure to;feasibility testing;Fostering;Foundations;Funding;Future;Goals;Grant;improved;improved outcome;insight;Intervention;Interview;Life;Lung;lung injury;Master of Science;Mathematics;Mechanical ventilation;Mechanical Ventilators;Mechanics;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Meta-Analysis;Methodology;Morbidity - disease rate;mortality;mortality risk;National Heart, Lung, and Blood Institute;novel strategies;Nurses;Observational Study;Outcome;Paralysed;participant enrollment;patient oriented;Patient-Focused Outcomes;Patients;Periodicity;Phase;Physicians;Physiological;Pilot Projects;pilot trial;Positive-Pressure Respiration;pressure;Productivity;prospective;Prospective Studies;Protocols documentation;Qualitative Methods;Qualitative Research;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Research;Research Methodology;Research Personnel;respiratory;Respiratory System;Risk Factors;Scientist;skills;Statistical Data Interpretation;Stress;Structure;Tidal Volume;Titrations;Training;transmission process;trial design;United States National Institutes of Health;Universities;ventilation;Ventilator;Ventilator-induced lung injury;Work

PROJECT_TITLE: Driving Pressure as a Target for Lung-Protective Ventilation

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: NARRATIVE Dr. Mezu-Ndubuisi seeks to first determine the most effective and least toxic doses of intravitreal VEGF-A165a and topical calcitriol eyedrop for the treatment of Retinopathy of Prematurity (ROP), a blinding eye disease in premature infants. Then, she will study how these drugs affect VEGF protein expression and signaling in ROP. Completion of this project will not only evaluate a new therapy, but will also delineate a new biological pathway of VEGF signaling during ROP.

PI_NAMEs: MEZU-NDUBUISI, OLACHI JOY (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Ablation;Adult;Affect;Age;Air;angiogenesis;Angiogenesis Inhibitors;Angiogenic Proteins;Apoptosis;Appointment;arterial tortuosity;bevacizumab;Binding;Biochemistry;Biological;Biometry;Blindness;Blood capillaries;Blood Vessels;Calcitriol;career;Cataract;central retinal artery;Childhood;clinical translation;Dedications;Diabetes Mellitus;Disease;Dose;effective therapy;Electroretinography;Endothelial Growth Factors Receptor;Environment;Equilibrium;experience;Extramural Activities;Eye diseases;Eyedrops;Fluorescein Angiography;Genes;glial activation;Goals;Growth;Growth Factor;Half-Life;Histologic;histological studies;Histopathology;Human;Hyperoxia;improved;in vivo;innovation;intraperitoneal;intravitreal injection;Ischemia;Knowledge;Laboratories;Longitudinal Studies;Low-Level Laser Therapy;Malignant Neoplasms;Measures;Mediating;Mentors;Methods;Molecular;Molecular Genetics;Monoclonal Antibodies;mouse model;Mus;neovascularization;novel;novel therapeutics;Ophthalmology;Optical Coherence Tomography;Optometrist;overexpression;Oxygen;particle;Pathogenesis;Pathway interactions;Patients;Pediatrics;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phenotype;postnatal;Premature Infant;preservation;professor;protein expression;Protein Isoforms;Protein Kinase;Proteins;Refractive Errors;Regulation;Research;Research Ethics;Research Personnel;research study;Resources;Retina;retina blood vessel structure;retinal angiogenesis;Retinal Detachment;Retinal Diseases;Retinopathy of Prematurity;revascularization;RNA Splicing;Role;Signal Transduction;Signaling Protein;skills;Structure;success;Synapses;synaptogenesis;systemic toxicity;Techniques;Testing;Therapeutic;therapeutically effective;Thick;Toxic effect;Training;Translational Research;trend;United States;United States National Institutes of Health;Universities;Variant;Vascular Endothelial Growth Factors;Vascularization;VEGFA gene;Veins;Venous;Vision;Visual;Visual Fields;Visualization;Vitamin D;Vulnerable Populations;Wisconsin

PROJECT_TITLE: Mechanism of intravitreal VEGF-A165a and topical calcitriol for the treatment of retinopathy of prematurity


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Kidney Disease;Machine Learning and Artificial Intelligence;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Clear cell ovarian cancer is a rare and lethal malignancy with limited treatment options. Molecularly it is similar to much more frequent clear cell renal carcinomas, of which around 25% respond to immunotherapy. We will take a systems biology approach to identify similarities in the ovarian and renal clear cell cancer tumor environments, and how cellular crosstalk in these environments drives therapy response.

PI_NAMEs: GENTLES, ANDREW J. (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Address;Algorithms;Antibodies;Appearance;Architecture;Automobile Driving;Bayesian learning;Biopsy;cancer cell;Cancer Patient;cancer type;Carcinoma;CD8-Positive T-Lymphocytes;Cell Communication;cell type;Cells;cellular imaging;checkpoint therapy;Clear Cell;Clear cell renal cell carcinoma;Clinical;Clinical Investigator;computer framework;Conventional (Clear Cell) Renal Cell Carcinoma;Data;data resource;Development;Dissection;Environment;experience;Gene Expression Profile;Genetic Transcription;Goals;Human;human disease;Image;imaging platform;Immune;Immune checkpoint inhibitor;immunogenic;Immunotherapy;improved;indexing;innovation;Intervention;Kidney;Knowledge;Learning;learning strategy;Malignant - descriptor;Malignant Epithelial Cell;Malignant neoplasm of ovary;Malignant Neoplasms;Methods;Microsatellite Instability;Modeling;Molecular;Molecular Analysis;Morphology;mouse model;Mus;Mutation;novel;novel marker;objective response rate;Outcome;Ovarian;Ovarian Clear Cell Tumor;Ovarian Endometrioid Adenocarcinoma;Ovarian Serous Adenocarcinoma;Patient Selection;Patients;pembrolizumab;Phenotype;predicting response;predictive marker;preservation;Property;Proteomics;rare cancer;response;Sample Size;Signal Transduction;single-cell RNA sequencing;Stromal Cells;Systems Analysis;Systems Biology;Testing;Tissue Microarray;TP53 gene;transcriptome sequencing;Transgenic Model;Translations;treatment response;tumor;tumor behavior;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;Validation;Work

PROJECT_TITLE: Systems analysis of mechanisms driving response to immunotherapy in clear cell cancers


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: 8. Project Narrative / Relevance. The nucleolus is not only the site of ribosome assembly, but also a dynamic genomic organization hub that recruits interactions with specific loci. We have found that several types of genomic interactions at the nucleolus surface are altered during events important for human health, including signaling of infections, differentiation processes, or during carcinogenesis and responses to anticancer treatment. We plan to use genome-scale methods to analyze how these interactions are altered, and to determine the mechanisms underlying these higher-order chromosome movements. These studies will provide invaluable tools and datasets for studying how human chromosomes respond to a variety of environmental stresses.

PI_NAMEs: FOLTZ, DANIEL RICHARD;HUANG, SUI ;KAUFMAN, PAUL D. (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: 3-Dimensional;Affect;anti-cancer treatment;Architecture;Binding;Biology;Cancer Biology;cancer cell;carcinogenesis;carcinogenicity;Cell Differentiation process;Cell Nucleolus;Cell Nucleus;cell type;Cell Wall;Cells;cellular targeting;Centromere;Characteristics;Chromatin;chromatin modification;chromosome missegregation;chromosome movement;Chromosome Segregation;Chromosomes;Cis-Acting Sequence;Clinical Trials;Complex;Cytology;Data;Data Set;deep sequencing;Disease;Dissociation;DNA;environmental stressor;Eukaryota;Event;experimental study;extracellular;Frequencies;functional outcomes;Gene Dosage;Gene Expression;genetic manipulation;Genetic Transcription;Genome;Genome Stability;genome-wide;genomic locus;Genomics;Goals;Health;Heterochromatin;histone modification;Histones;Human;Human Chromosomes;Human Genome;Immune;Immune signaling;Infection;Inflammatory;Innate Immune System;Interphase Cell;Investigation;Kinetics;Label;Learning;Link;Lipopolysaccharides;Macrophage;Malignant Neoplasms;malignant phenotype;MAP Kinase Gene;Maps;Measurement;Mediating;member;Methods;Mitotic spindle;Modification;Molecular;monocyte;Mus;Natural Immunity;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel;Nuclear;Nucleolar Proteins;Organelles;p38 Mitogen Activated Protein Kinase;pathogen;Phase;Prevalence;Process;Property;Proteins;recruit;Repetitive Sequence;Research Personnel;response;Ribosomal RNA;Ribosomes;RNA;RNA-Binding Proteins;Role;Satellite DNA;Series;Shapes;Signal Pathway;Signal Transduction;Site;Stimulus;Stress;Structure;Surface;System;Testing;Therapeutic;therapeutic lead compound;tool;Transducers;tumor xenograft;Untranslated RNA

PROJECT_TITLE: The role of the nucleolus in human genome organization in normal and disease states

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(70)R]


NIH_SPENDING_CATS: Genetics;Human Genome

PHR: Public Health Relevance This proposal will provide support to plan and coordinate the NHGRI Research Training and Career Development Annual Meeting. The annual meeting provides an excellent opportunity to showcase trainees’ work through poster and platform presentations, to provide the experience of a professional scientific meeting, and to network. These annual meetings provide trainees with a valuable learning opportunity and platform for their educational advancement and career growth for the next generation of genome scientists and providers.

PI_NAMEs: HAGA, SUSANNE  (contact)

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Achievement;Address;Advisory Committees;Area;Award;Budgets;career;career development;Collaborations;Communities;COVID-19;Development;Education;Employment;Ensure;Environment;ethical, legal, and social implication;Evaluation;Event;experience;Faculty;Feedback;flexibility;Fostering;Genome;genome sciences;Goals;Growth;Health;higher education;innovative technologies;interest;Intervention;Justice;Learning;Light;Location;Medicine;meetings;Mentors;Mentorship;National Human Genome Research Institute;new technology;next generation;novel coronavirus;online resource;peer support;Personal Satisfaction;Persons;Phase;Postdoctoral Fellow;posters;Preparation;Productivity;programs;Provider;public health relevance;Race;Research;Research Training;Reservations;Scientist;Site;Structure;symposium;Training;training opportunity;Uncertainty;undergraduate student;virtual;web site;Work

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Nutrition;Pediatric;Physical Activity;Prevention;Rural Health;Social Determinants of Health;Substance Misuse;Underage Drinking;Vaccine Related

ORG_CITY: GOLDEN

ORG_NAME: KLEIN BUENDEL, INC.

ORG_STATE: CO

PHR: Young adults aged 18-26 engage in a number of behaviors that increase their risk of developing cancer later in life including sedentary lifestyles, unhealthy eating, nicotine produce us, heavy drinking of alcohol, increased UV exposure, and incomplete uptake of HPV vaccination. A multi-risk factor campaign will be developed to reduce these cancer risk behaviors and delivered to young adults over social media, a popular channel that can reach nearly all young adults. The campaign will be evaluated for effectiveness in a rigorous randomized trial with measures of moderate to vigorous physical activity, healthy eating patterns, nicotine product use, alcohol intake, sunburn prevalence, and HPV vaccination uptake.

PI_NAMEs: BULLER, DAVID B (contact);SUSSMAN, ANDREW LOUIS

PROGRAM_OFFICER_NAME: CHOU, WEN-YING

PROJECT_TERMS: Address;Affect;aged;Alcohol consumption;Alcohols;American Cancer Society;Arizona;Behavior;Behavior Therapy;Behavioral;Belief;biological sex;Cancer Center;Cancer Control;cancer prevention;Cancer Prevention Intervention;cancer risk;Clinic;cohort;Colorado;Communication;Communities;community engagement process;Comprehensive Cancer Center;cost;Data Analytics;design;digital;digital media;Eating;effectiveness evaluation;emerging adult;Employment;Enrollment;Ethnic Origin;experience;Facebook;Family;flexibility;Food;Geography;Gills;Goals;Guidelines;Health;health care service utilization;Healthcare;Healthy Eating;Heavy Drinking;HPV vaccine acceptance;Human Papilloma Virus Vaccination;improved;Individual;Information Dissemination;innovation;Instruction;Internet;Intervention;Intervention Studies;Knowledge;Life;literacy;literate;Literature;Malignant Neoplasms;Marketing;Measures;Media Campaign;Media Intervention;Mediating;Misinformation;moderate-to-vigorous physical activity;modifiable risk;New Mexico;Nicotine;Participant;Pattern;Physical activity;Population;Population Heterogeneity;pragmatic randomized trial;Prevalence;prevent;Prevention program;Preventive healthcare;Privatization;prospective;prospective test;Protocols documentation;public trust;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Research;Research Personnel;Resources;response;Risk;Risk Behaviors;Risk Factors;Rural;rural area;Rural Community;rural counties;Rural Population;rural underserved;School Enrollments;Schools;sedentary lifestyle;skills;social interventions;social media;Social support;socioeconomics;sun protection;Sunburn;Surveys;Testing;theories;tobacco advertising;trend;underserved area;Unhealthy Diet;United States;United States National Institutes of Health;Utah;UV Radiation Exposure;Vaccines;Voice;Workplace;young adult

PROJECT_TITLE: #4Corners4Health: A Social Media Cancer Prevention Program for Rural Emerging Adults


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Immunotherapy;Mental Health;Radiation Oncology

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Narrative Resistance to radiation therapy is a major clinical concern when treating patients with cancer, and understanding the biological mechanisms driving this process is an important next step in improving patient outcomes. The goal of this proposal is to define how chronic stress, mediated by the sympathetic nervous system and β-adrenergic signaling, induces tumor cell intrinsic resistance to irradiation, and to determine whether these changes in tumor cell death affect key activators of anti-tumor immunity, like dendritic cells. Ultimately, the studies within this proposal have the potential to define a novel mechanism of tumor cell mediated radioresistance, lay the groundwork for future clinical studies, and improve patient outcomes.

PI_NAMEs: MACDONALD, CAMERON RIKER (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: adaptive immunity;Address;Adenosine;Adrenergic Agents;adrenergic stress;Affect;Agonist;antagonist;anti-tumor immune response;antigen detection;Antigens;Anxiety;Apoptosis;Automobile Driving;beta-adrenergic receptor;Biological;Bone Marrow;calreticulin;cancer cell;Cancer Patient;cancer therapy;Catabolism;CD8-Positive T-Lymphocytes;Cell Death;Cell Death Induction;Cell Death Process;cell injury;Cell Line;Cell Maturation;Cell Physiology;Cell Survival;cell type;Cells;Cessation of life;Chronic;Chronic stress;Clinical;Clinical Research;Coculture Techniques;Cultured Tumor Cells;Cyclic AMP;cytokine;Data;Dendritic Cells;Distant;Dose;Enzymes;Event;experience;experimental study;Future;Generations;Genetic;genetic approach;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Guidelines;HMGB1 gene;Human;Immune;immune activation;Immune response;immunogenic;immunogenic cell death;Immunologic Stimulation;Immunologics;Impairment;Implant;improved;in situ vaccine;In Vitro;in vivo;Innate Immune Response;interest;Irradiated tumor;irradiation;Isoproterenol;knock-down;Lead;lymph nodes;Malignant Neoplasms;Measures;Mediating;migration;Molecular;Mouse Strains;Mus;Necrosis;Neoplasm Metastasis;neoplastic cell;Neurotransmitters;Norepinephrine;novel;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Phagocytosis;pharmacologic;Physiological;Play;Process;Production;Proliferating;Propranolol;Publishing;Quality of life;Radiation;Radiation Dose Unit;radiation effect;radiation resistance;radiation response;Radiation therapy;receptor;recruit;Regimen;Research;Resistance;response;Role;Series;Signal Induction;Signal Pathway;Signal Transduction;Stimulator of Interferon Genes;Stress;stress reduction;Sympathetic Nervous System;T-Cell Activation;Technology;Testing;therapy resistant;Time;trafficking;tumor;Tumor Antigens;Tumor Cell Line;Tumor Immunity;tumor microenvironment

PROJECT_TITLE: The impact of chronic stress on radiation induced cell death and the anti-tumor immune response


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunization;Immunotherapy;Vaccine Related;Women's Health Research

PHR: NARRATIVE Immunotherapy has shown the promise to cure cancer by boosting the anticancer immune response, but is still limited by low patient response rate, poor efficacy against solid tumors, and/or severe side effects. Targeted modulation of type 1 conventional dendritic cells, superior in antigen cross-presentation, in lymph nodes will enable optimal activation of T cell responses for the development of robust and safe immunotherapy.

PI_NAMEs: WANG, HUA  (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: 4T1;Adjuvant;Alginates;anti-cancer;anti-tumor immune response;Antigen Presentation;antigen-specific T cells;Antigens;Autoimmune Diseases;Biocompatible Materials;cancer immunotherapy;Cancer Vaccines;CAR T cell therapy;CD8-Positive T-Lymphocytes;Cell Communication;Cell membrane;Cell surface;Cells;Chemicals;Chemistry;chemokine;clinical translation;Communicable Diseases;Cross Presentation;cytokine;cytokine therapy;Cytotoxic T-Lymphocytes;Dendritic Cells;Development;effector T cell;experimental study;Future;Gel;Glycoengineering;Goals;Homing;Hour;Hydrogels;Immune;immune checkpoint blockade;immune modulating agents;Immune response;immunoengineering;immunogenic;Immunology;Immunomodulators;Immunotherapy;improved;In Situ;In Vitro;in vivo;Injectable;Interleukin-12;Interleukin-15;interleukin-21;Kinetics;Label;Liposomes;lymph nodes;Malignant Neoplasms;Mediating;Melanoma;Membrane;Metabolic;migration;nanovaccine;neoantigens;patient response;Polysaccharides;Process;rational design;recruit;Research;response;Role;scaffold;side effect;Solid Neoplasm;Subcutaneous Injections;success;sugar;Surface;System;T cell response;T-Cell Activation;T-Lymphocyte;targeted delivery;Technology;Testing;therapy development;Time;Toxic effect;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;tumor-immune system interactions;Vaccines;Viscosity

PROJECT_TITLE: Biomaterials for Targeted Modulation of Conventional Type 1 Dendritic Cells

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE  We aim to conduct a multi-center, pragmatic, cluster randomized, controlled trial to assess the impact of a provider- and patient-directed intervention to increase the prescription of, and adherence to, appropriate statin therapy among those with ASCVD, and particularly among Blacks. As with all pragmatic trials that operate outside of the traditional clinic-based recruitment model, the optimal method to reach and engage both clinicians and patients in this trial is uncertain. Our objective for this planning grant is to determine whether our strategies for clinician and patient recruitment yield a high enough degree of engagement, including among Blacks, to justify moving forward with the larger trial.

PI_NAMEs: GRANGER, CHRISTOPHER B. (contact);PLATT, RICHARD

PROGRAM_OFFICER_NAME: TATAW-AYUKETAH, GLADYS OROCK

PROJECT_TERMS: Adherence;Area;Atherosclerosis;Authorization documentation;black patient;Black Populations;Black race;Blood Vessels;cardiovascular risk factor;Cause of Death;Clinic;clinical practice;Clinical Research;Clinical Trials;Dose;Eligibility Determination;Enrollment;Event;evidence base;Future;Goals;Grant;improved;Individual;Intervention;Methods;Modeling;mortality;multi-component intervention;National Committee for Quality Assurance;Participant;Patient Compliance;patient engagement;patient population;Patient Recruitments;Patients;Pharmaceutical Preparations;Pharmacists;pragmatic trial;programs;Provider;Randomized, Controlled Trials;Recording of previous events;Records;recruit;Risk Reduction;System;Therapeutic;therapy adherence;Time;United States;Work

PROJECT_TITLE: ACHIEVE

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


NIH_SPENDING_CATS: Biotechnology;Bipolar Disorder;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Psychosis;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The Populations Underrepresented in Mental illness Association Studies (PUMAS) Project will collect samples from 17,000 individuals with severe mental illness from across African and the Americas to create a total sample dataset of 183,000 from across Africa and the Americas. We will generate and analyze whole genome sequencing data on 40,000 schizophrenia patients, 40,000 bipolar patients and 40,000 controls to learn the similarities and differences of the genetic architecture of severe mental illness across diverse ancestries and environments.

PI_NAMEs: FREIMER, NELSON B. (contact);LOPEZ JARAMILLO, CARLOS ;OLDE LOOHUIS, LOES MARLEIN;OPHOFF, ROEL A

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Abbreviations;Africa;African;African ancestry;Americas;Area;Biological;Bipolar Disorder;bipolar patients;Code;cohort;Collaborations;Collection;Computerized Medical Record;Copy Number Polymorphism;Data;Data Set;data sharing;Diagnostic;Disease;Environment;Ethnic Origin;European ancestry;exome;exome sequencing;Gene Frequency;Generations;Genes;Genetic;genetic architecture;Genetic Research;Genetic study;Genetic Variation;genome sequencing;Genomics;Genotype;health care disparity;Individual;insight;International;Interview;knowledge base;Latin American;Latino;Latino Population;Learning;Letters;Linkage Disequilibrium;Maps;Medicine;Mental disorders;Meta-Analysis;Mood Disorders;Mutation;National Institute of Mental Health;Native American Ancestry;Native Americans;neuropsychiatry;Outcome;Patients;Phenotype;polygenic risk score;Population;Population Control;Population Heterogeneity;Principal Component Analysis;psychiatric genomics;Psychiatry;psychogenetics;Psychoses;Psychotic Disorders;Quality Control;Questionnaires;rare variant;recruit;Reduce health disparities;Research Personnel;response;risk variant;Sample Size;Sampling;Sampling Studies;Schizoaffective Disorders;Schizophrenia;screening;severe mental illness;Severities;Single Nucleotide Polymorphism;South Africa;South America;success;Underrepresented Populations;Variant;variant detection;whole genome

PROJECT_TITLE: 4/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African Ancestries


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Boston

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: Project Narrative Racism is a continued threat to public health and a major factor in the morbidity and reduced life expectancy of Black Americans and hence is one of the most urgent and broadly impactful crises of contemporary society, yet the mechanistic pathways linking personal racism experiences with adverse health outcomes have not been examined using rigorous neuroscience techniques within an interdisciplinary framework. The proposed research will be conducted by an interdisciplinary team including trainees from underrepresented groups, will examine the effects of personal experiences with racism on the brain, mind, and body, and will determine how these changes associate with adverse health outcomes.

PI_NAMEs: ALLEN, AERIELLE ;SHIN, LISA MARIE (contact);SOMMERS, SAMUEL

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Address;Affect;African American;Area;Autobiography;Biological Markers;Black American;Black race;Brain;cardiovascular disorder risk;Career Mobility;Cell Aging;Cellular Phone;Chronic;Clinical Psychology;Clinical Research;Collection;coping;cost;Dimensions;Disparity;DNA;Ecological momentary assessment;Elements;emotion regulation;experience;Exposure to;Frequencies;Funding;Goals;Hair;Health;health disparity;Hydrocortisone;innovation;insight;Intervention;Investigation;Length;Life;Life Expectancy;Life Experience;Link;Longitudinal Studies;Measurable;Measures;Mediating;Methodology;Methods;Mind;mindfulness;Minority;Minority Groups;Morbidity - disease rate;mortality;National Institute of Mental Health;neural;neuroimaging;Neurosciences;novel;Outcome;Participant;Pathway interactions;Patient Self-Report;Personal Satisfaction;Persons;Physiological;Population;Postdoctoral Fellow;prevent;Process;prospective;psychologic;psychological distress;Psychologist;Psychopathology;Public Health;racism;Research;Research Domain Criteria;Research Methodology;Research Personnel;Research Project Grants;response;Risk;Severities;social health determinants;Social support;Societies;Stimulus;Stress;stressor;Techniques;telomere;Time;Training;Trauma;undergraduate student;Underrepresented Populations;United States National Institutes of Health

PROJECT_TITLE: Effects of Racism on Brain and Physiological Pathways to Health Disparities


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: NARRATIVE The results of the proposed experiments will significantly enhance our understanding of the molecular mechanisms underlying sensory neuron responses and hopefully provide novel information for use in the development of new avenues of research and therapies for musculoskeletal pain and/ or altered cardiovascular reflexes associated with repetitive ischemia/ reperfusion injury. The information obtained from these novel studies will allow us to better understand the functional implications of sensitization in specific subpopulations of muscle sensory neurons and the role they play in sex specific development of ischemic myalgia.

PI_NAMEs: JANKOWSKI, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Ablation;Acute;Affect;Afferent Neurons;Automobile Driving;Behavior;Behavioral;behavioral response;Cardiovascular Diseases;Cardiovascular system;Cell Nucleus;Cells;Chronic;cytokine;Data;Development;Disease;Electrophysiology (science);Elements;Exercise;experience;experimental study;Family;Family member;Female;Formulation;Gene Expression;Genes;Genetic Complementation Test;glial cell-line derived neurotrophic factor;Goals;Growth Factor;Health;Hematological Disease;Immune;in vivo;Individual;Injury;innovation;insight;Interleukin-1 Receptors;Interleukins;Ischemia;knock-down;Knock-out;Knowledge;Macrophage;male;Mediating;member;Molecular;mouse model;Mus;Muscle;Muscle Fibers;Musculoskeletal Pain;Myalgia;Nerve;Neurobiology;Nociceptors;novel;novel therapeutics;Outcome;Pain;Pain Measurement;Pain Threshold;Pathway interactions;Perfusion;Peripheral;Peripheral Nerves;Peripheral Vascular Diseases;Persistent pain;Persons;Play;Population;Preparation;Prevalence;prevent;Process;Property;ras Oncogene;receptor;Reflex action;Reperfusion Injury;Reperfusion Therapy;Reporting;Research;response;RNA Sequences;RNA-Binding Proteins;Role;sensory mechanism;sex;Sex Differences;Sickle Cell Anemia;Signal Transduction;Skeletal Muscle;Skin;Small Interfering RNA;Source;Spinal Cord;Spinal Ganglia;Testing;Tissues;transcription factor;Transgenic Organisms;United States;Up-Regulation;women versus men

PROJECT_TITLE: Mechanisms of muscle afferent sensitization after ischemia

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]