ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Genetics

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Type II topoisomerases are essential for the relief of topological tensions during transcription, replication, and chromosome segregation. This proposal aims to elucidate the mechanisms by which several specific regulators act together to ensure proper turnover of these topoisomerases, which is critically important for DNA damage avoidance and cell survival. .

PI_NAMEs: CHEN, JUNJIE  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Active Sites;Agreement;Antineoplastic Agents;Biology;Bypass;cancer therapy;Cell Cycle Inhibition;Cell Cycle Progression;Cell Death;Cell Proliferation;Cell Survival;Cells;Chromatin;Chromosome Segregation;Complex;CRISPR screen;DNA;DNA Adducts;DNA Damage;DNA lesion;DNA Repair;DNA strand break;DNA Topoisomerases;Ensure;Enzymes;Etoposide;Eukaryota;Excision;experimental study;Fission Yeast;follow-up;Genes;Genetic Transcription;Human;Knock-out;Lesion;Link;Literature;Mammalian Cell;Mediating;neoplastic cell;Pathway interactions;Poison;Process;Prokaryotic Cells;protein protein interaction;Proteins;Reaction;Regulation;repaired;Research Personnel;Resistance;response;Role;Rotation;Signal Transduction;Somatic Cell;SPO11 gene;Stress;Superhelical DNA;Testing;Therapeutic;TOP1 gene;TOP2A gene;Topoisomerase;Topoisomerase II;Topoisomerase III;treatment response;Type I DNA Topoisomerases;Tyrosine;Vertebral column;whole genome;Work

PROJECT_TITLE: Deciphering pathways involved in topoisomerase II turnover

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric;Regenerative Medicine

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative This study aims to reveal the physiological triggers of cardiac regenerative potential loss during postnatal growth. This will provide novel insights into organ regeneration, possibly suggesting new targets and strategies to treat heart failure.

PI_NAMEs: HUANG, GUO  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Adipocytes;Adipose tissue;Adrenergic Agents;Adrenergic Receptor;Adult;Alleles;ATP Synthesis Pathway;Biological Assay;Birth;Blood flow;Blood Vessels;Body Temperature;Brain;Cardiac;Cardiac Myocytes;Cardiac Output;cardiac regeneration;cardiac repair;Cardiovascular system;Cell Cycle;Cell Cycle Arrest;Cell division;Circulation;Communication;Complex;Exhibits;experimental study;Family suidae;Fatty acid glycerol esters;Fractals;Growth;Heart;heart damage;Heart Diseases;Heart failure;heart function;Image;improved;Induced Cardiomyocytes;Injury;injury and repair;insight;ischemic injury;Life;Link;Mammals;Mediating;Metabolic;Mitochondria;Molecular;Mus;Myocardial Infarction;Natural regeneration;neonatal mice;Newborn Infant;novel;Octadecenoic Acids;Organ;organ regeneration;Pathway interactions;Perinatal;Phylogeny;Physiological;Physiology;Ploidies;Polyploidy;postnatal;Process;Proliferating;Protons;Proxy;Receptor Signaling;regeneration potential;Regenerative capacity;regenerative repair;Regenerative response;regenerative tissue;Regulation;Reporting;Rodent;Role;Science;self-renewal;Signal Pathway;Signal Transduction;Signaling Molecule;Skin;Testing;Thermogenesis;Thyroid Hormone Receptor;Thyroid Hormones;Tissues;uncoupling protein 1;Uterus;Vertebrates;Withdrawal;Zebrafish

PROJECT_TITLE: Molecular control of cardiac regenerative potential

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Immunotherapy;Precision Medicine;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE Cancer immunotherapy is a promising antitumor therapy, but the success in solid tumors especially prostate cancer has been limited. While current immunotherapies focus on targeting the T cell compartment, combination therapies that incorporate activation of the myeloid compartment could increase the efficacy of immunotherapy in solid tumors. I have profiled single cell transcript and protein expression in peripheral immune cells in a prostate cancer cohort during combined immunotherapy treatment, and I will use this dataset to investigate the heterogeneity of the myeloid compartment and how that heterogeneity relates to treatment response.

PI_NAMEs: MCCARTHY, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;Age;androgen independent prostate cancer;anti-CTLA4;Antigen-Presenting Cells;Autoimmune;B-Cell Activation;cancer immunotherapy;cancer type;career;Cell Communication;Cell Compartmentation;Cells;Clinical;clinical predictors;clinical training;clinical trial participant;Clonality;cohort;Combination immunotherapy;Combined Modality Therapy;Complementary DNA;Computing Methodologies;Cytometry;Data;Data Set;Dendritic Cell Vaccine;Development;Ethnic Origin;Evolution;Expression Profiling;Foundations;Gender;Gene Expression;Genes;Genetic;Genetic Transcription;Genomics;Goals;Heterogeneity;high dimensionality;Immune;Immune checkpoint inhibitor;Immune response;Immune system;immunogenic;Immunologic Monitoring;Immunologic Stimulation;Immunology;Immunotherapy;improved;in vivo;Infusion procedures;ipilimumab;Learning;Length;Lymphoid;Lymphoid Cell;Malignant neoplasm of prostate;method development;Microsatellite Instability;Mismatch Repair Deficiency;Modeling;Monitor;Morbidity - disease rate;mortality;Multiplexed Ion Beam Imaging;Myelogenous;Myeloid Cells;novel;Oncology;Participant;patient subsets;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Phenotype;Physicians;Play;predicting response;predictive signature;programs;Prostate-Specific Antigen;Protein Analysis;protein expression;Proteomics;Protocols documentation;Provenge;response;response biomarker;Role;Sampling;Scientist;single cell proteins;skills;Solid Neoplasm;success;T cell response;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Time;Tissue Sample;tool;Transcript;treatment response;tumor;Tumor Burden;tumor microenvironment;Tumor Tissue;Urogenital Cancer;Work

PROJECT_TITLE: Discovery of myeloid immune features predictive of response to cancer immunotherapy in prostate cancer


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: BELTSVILLE

ORG_NAME: PACIFIC INSTITUTE FOR RES AND EVALUATION

ORG_STATE: MD

PHR: PROJECT NARRATIVE The `Environmental Approaches to Prevention' Center Grant supports innovative basic and applied research that contributes to the development and implementation of cost-effective environmental prevention policies and programs at the organizational, local, state, and national levels. Research conducted at the Center has practi- cal importance by informing policies and programs to prevent alcohol-related problems. The Center summa- rizes, synthesizes, and disseminates new and existing knowledge about prevention theories, policies, and pro- grams, and provides multidisciplinary training and research opportunities for post-doctoral fellows and other early investigators.

PI_NAMEs: PASCHALL, MALLIE J (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent and Young Adult;Affect;Age;Alcohol abuse;alcohol availability;Alcohol consumption;Alcohol Laws;alcohol misuse prevention;alcohol prevention;alcohol related problem;alcohol use disorder;Alcohols;Applied Research;Area;Basic Science;behavioral and social science;Behavioral Sciences;Belief;Beverages;Biological;Cannabis policy;Communities;contextual factors;cost effective;Data;Databases;Development;Developmental Process;drinking;Economics;effectiveness study;efficacy study;emerging adult;Environment;Environmental Risk Factor;ethnic difference;ethnic disparity;Etiology;Evaluation;field study;Geographic Locations;Goals;Grant;Heavy Drinking;high risk;implementation cost;implementation study;improved;Individual;innovation;insight;interdisciplinary approach;interest;Interpersonal Violence;Intervention;Knowledge;legal drinking age;Life;Location;Marijuana;marijuana legalization;marijuana use;Mission;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;Neighborhoods;novel;older adult;Outcome;Pattern;Peer Review;Persons;Policies;Population;Postdoctoral Fellow;Prevention;Prevention approach;Prevention Research;Process;programs;Prospective cohort;Prospective, cohort study;psychologic;Public Health;public policy on alcohol;Research;Research Institute;Research Personnel;Risk;Role;Sales;social;Social Sciences;Socioeconomic Factors;Structure;Taxes;Testing;theories;Time;Training;Translational Research;Vehicle crash;Western Australia;young adult;Youth

PROJECT_TITLE: Environmental Approaches to Prevention


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Prevention;Substance Misuse;Substance Misuse Prevention

PROJECT_TERMS: Access to Information;alcohol prevention;Alcohols;Applications Grants;Awareness;base;Behavioral Sciences;Budgets;Collection;Computer Hardware;Computer software;Computers;Consultations;cost;Creativeness;Data;Data Analyses;Data Collection;data management;design;Development;editorial;Electronics;Ensure;Equipment;Evaluation;executive function;Financial Support;flexibility;Fostering;Funding;Goals;Grant;Human Resources;human subject;Information Systems;Information Technology;Infrastructure;innovation;Institution;Interlibrary Loans;Internet;Libraries;Maintenance;Maps;Mass Media;meetings;Methods;Monitor;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;Occupational activity of managing finances;Parents;Performance;Personnel Recruitments;Policies;Postdoctoral Fellow;Prevention;Prevention approach;Prevention Research;Principal Investigator;Privatization;professional atmosphere;Professional Meetings and Conferences;Professional Organizations;programs;Research;research data dissemination;Research Institute;Research Project Grants;Resources;Science;Scientist;Section 8;Services;Social Sciences;Source;Structure;symposium;Technology Transfer;Time;Training;Word Processing;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Genetics;Immunotherapy;Radiation Oncology;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PI_NAMEs: VIOLA, NERISSA THERESE (contact)

PROJECT_TERMS: Algorithms;anatomic imaging;Angiogenesis Inhibitors;animal imaging;Animals;Antibodies;Atlases;Biological;Biomedical Engineering;Biopsy;Breast Carcinoma;breast density;breast imaging;Cancer Center;Cancer Center Support Grant;Cancer Detection;cancer imaging;cancer infiltrating T cells;cancer therapy;carbonate dehydratase;carcinogenesis;CD44 gene;Cervix Carcinoma;chemotherapy;Clinic;Clinical;clinical care;Collaborations;commercialization;Complement;Contrast Media;Core Facility;Cyclotrons;Deacetylase;density;Detection;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Discipline of Nuclear Medicine;Drug Delivery Systems;Drug Industry;Drug Targeting;early phase clinical trial;Effectiveness;efficacy study;elastography;Energy Metabolism;Enzymes;Epidermal Growth Factor Receptor;Epigenetic Process;epigenetic regulation;ERBB2 gene;ERBB3 gene;Functional Imaging;Funding;Gene Expression;gene product;Gene Proteins;Gene Silencing;Genes;Genetic;Goals;HDAC4 gene;HDAC5 gene;Heterogeneity;Histone Deacetylase;Image;imaging agent;imaging biomarker;Imaging Device;imaging modality;imaging program;imaging scientist;imaging system;Imaging technology;Immune checkpoint inhibitor;Immunotherapy;improved;In Situ;In Vitro;innovation;Institution;instrument;instrumentation;Kynurenine;Legal patent;Liposomes;Lysine;Magnetic Resonance Imaging;Mainstreaming;Maintenance;Malignant Neoplasms;Manuscripts;Maps;Measurement;Measures;member;Metabolic Pathway;Methodology;Methods;microPET/CT;microSPECT;Mitochondrial Proteins;Molecular;molecular imaging;Monitor;nanoliposome;nanoparticle;novel;novel therapeutic intervention;Oncologist;Optical Coherence Tomography;Optics;Oxidation-Reduction;Pathway interactions;Peer Review;PET/CT scan;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phase III Clinical Trials;photoacoustic imaging;Physicians;Physiology;Positron-Emission Tomography;pre-clinical;pre-clinical research;Procedures;programs;Protein Isoforms;Publishing;Radiation;Radiation therapy;Radiochemistry;radiologist;radiotracer;receptor;Regimen;Registries;Regulation;Research;research and development;Research Personnel;Resistance;Resource Sharing;response;Risk Assessment;Schools;Signal Transduction;SIRT1 gene;Skin;Source;Specimen;spectroscopic imaging;Spectrum Analysis;Speed;Staging;structural imaging;Sun Exposure;System;Techniques;Therapeutic;therapeutic siRNA;Tissues;tomography;Toxic effect;Tracer;Translating;transmission process;Treatment Efficacy;treatment response;tumor;Tumor Biology;tumor hypoxia;tumor metabolism;tumor microenvironment;tumor progression;tumorigenesis;ultrasound;Universities;uptake;Vaccines;Viola;Work

PROJECT_TITLE: Molecular Imaging


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Recovery Support Services;Rehabilitation;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: Project Narrative. This project will document the near real time associations between Alcoholics Anonymous (AA) prescribed behaviors, four underlying mechanisms accounting for behavior change, and drinking outcome among early AA affiliates. Achievement of study aims will generate an empirically-based AA process model that will provide highly relevant information for improving 12-step treatment in the United States.

PI_NAMEs: TONIGAN, J. SCOTT (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Abstinence;Accounting;Achievement;Address;Adolescent;Adult;alcohol abstinence;alcohol abuse therapy;alcohol related problem;Alcoholics Anonymous;Alcohols;Behavior;behavior change;Behavioral Mechanisms;catalyst;Client;Cognition;Communities;comparison group;cost;critical period;Data;Data Collection;design;Development;disease model;drinking;Ecological momentary assessment;Effectiveness;ethnic diversity;Evaluation;Frequencies;Goals;Heterogeneity;improved;Impulsivity;innovation;Intercept;Interview;Investigation;longitudinal design;Longitudinal Studies;Measurement;Mediating;Mediator;meetings;Modeling;multi-site trial;Outcome;Persons;Population Heterogeneity;problem drinker;Process;programs;Property;Protocols documentation;Provider;Randomized;rate of change;Recording of previous events;Research;Research Personnel;Research Support;Resources;Sampling;Self Efficacy;self help;Social support;Spirituality;substance abuse treatment;success;Testing;Time;Treatment outcome;Treatment Step;United States;Work

PROJECT_TITLE: Development of a Comprehensive and Dynamic AA Process Model: One Day at a Time

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Prevention;Substance Misuse;Substance Misuse Prevention

PI_NAMEs: THOMAS, SUE  (contact)

PROJECT_TERMS: Adoption;Advocate;Alcohol abuse;alcohol and other drug;Alcohol consumption;alcohol prevention;alcohol research;Alcohols;Area;Awareness;Budgets;California;Communities;Community Actions;community based practice;community intervention;community setting;design;Event;Evidence based practice;experience;Facebook;Focus Groups;Future;Government Officials;Grant;implementation science;interest;Investigation;Learning;Link;LinkedIn;Local Government;member;Narration;Policies;policy implication;Policy Maker;Policy Making;preference;prevent;Prevention approach;Prevention Research;Public Health;Publishing;Reporting;Research;Research Personnel;Resources;Sampling;Scanning;Scientist;Slide;social media;symposium;tool;Translating;Translations;Twitter;United States;Voice;web site;Work

PROJECT_TITLE: Information and Dissemination in Support of Community Interventions


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: A comprehensive understanding of influenza A virus (IAV) biology is imperative should we wish to develop an effective long-term solution to this global burden. This proposal focuses on the biology of the RNA dependent RNA polymerase and its interaction with small virus-derived RNAs (svRNAs). The research outlined here will enable a greater understanding of how IAV coordinates infection of the cell and effectively replicates.

PI_NAMEs: TENOEVER, BENJAMIN R. (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Anti-viral Agents;Binding;Binding Sites;Biology;Cell Nucleus;Cells;combat;Complex;cytotoxicity;Data;Detection;Development;differential expression;endonuclease;Ensure;experimental study;Future;Generations;Genes;Genetic Transcription;Genome;Grant;Immune response;improved;Infection;Inflammatory;Influenza A virus;Knowledge;Length;Life Cycle Stages;manufacture;Mediating;Mutation;Nature;next generation sequencing;novel therapeutics;Nucleotides;pandemic disease;Pathogenesis;Phenotype;Play;Polymerase;Population;Positioning Attribute;previous epidemic;Process;Production;Proteins;Recombinants;Recording of previous events;Research;response;RNA;RNA Interference;RNA-Directed RNA Polymerase;Role;Small RNA;Specificity;System;Technology;Therapeutic;Time;Transcript;transcriptome sequencing;Untranslated RNA;vaccine development;Vaccines;Viral;Viral Pathogenesis;Viral Physiology;viral RNA;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Small viral RNAs as determinants of influenza A virus pathogenesis

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: RESEARCH NARRATIVE Follicular lymphoma and diffuse large B-cell lymphoma represent the two most common forms of human B cell lymphoma and remain incurable in a significant fraction of patients. This research proposal seeks to elucidate how missense mutations of the CREBBP acetyltransferase, the second most frequent genetic alteration in these tumors, contribute to malignant transformation by reprogramming the pre-neoplastic germinal center B cells as well as the immune microenvironment. The outcome of these studies is expected to further our understanding of the biology of these common cancers and to pave the basis for the development of improved biomarkers and therapeutic approaches.

PI_NAMEs: PASQUALUCCI, LAURA  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Accounting;Acetylation;Acetyltransferase;Affect;Alleles;Antigen Presentation Pathway;Antigen-Presenting Cells;ATAC-seq;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Lymphocytes;BCL2 gene;Biological Assay;Biological Markers;Biology;Cancer Etiology;Cell Separation;Cells;ChIP-seq;Chromatin;Clinical;Complex;conventional therapy;Coupled;CREBBP gene;Data;Dependence;Development;Diagnosis;Diagnostic;Disease;Disease remission;DNA Sequence Alteration;dosage;Enhancers;Epigenetic Process;Event;Evolution;Fluorescence Microscopy;Follicular Lymphoma;founder mutation;Frequencies;Gene Expression Profile;Gene Modified;Genetic;Genetic Transcription;Goals;Human;improved;in vivo;Incidence;Indolent;Induced Mutation;Inferior;insight;Knock-in Mouse;Knock-out;Knockout Mice;large cell Diffuse non-Hodgkin's lymphoma;Lesion;Link;Lymphoma;Lymphomagenesis;Maintenance;Malignant - descriptor;Malignant lymphoid neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Memory B-Lymphocyte;microscopic imaging;Missense Mutation;Modeling;Modification;Molecular;mortality;mouse model;Mouse Strains;Mus;mutant;Mutate;Mutation;Nature;neoplastic;Neoplastic Cell Transformation;Non-Hodgkin's Lymphoma;Non-Malignant;novel therapeutic intervention;Oncogenic;Outcome;Outcome Study;Pathogenesis;patient population;Patients;Pattern;Phenotype;Phylogenetic Analysis;Plasma Cells;precursor cell;programs;protein expression;Proteins;recruit;Recurrence;Relapse;Reporting;Research;Research Proposals;response;RNA Decay;Role;Sampling;Signal Transduction;single cell analysis;single-cell RNA sequencing;Somatic Mutation;stem cells;Structure;Structure of germinal center of lymph node;synergism;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutic target;TNFRSF5 gene;transcriptome sequencing;tumor;Tumor Suppressor Proteins;tumor-immune system interactions;United States;Validation;Work

PROJECT_TITLE: Role of CREBBP missense mutations in lymphomagenesis

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE In the first hours of development, the embryo undergoes rapid cycles of DNA replication followed by high-level transcription of sets of genes required for subsequent developmental processes. We will test the hypothesis that pioneer transcription factors like Zelda in Drosophila play a dual role, first to mark origins of DNA replication, then at those same sites, transcriptional activation. Our findings will have broad implications for pioneer factors in coordinating developmental events in more complex organisms.

PI_NAMEs: RUSHLOW, CHRISTINE A (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Binding;Blastoderm;Body Patterning;Chromatin;Complex;Development;Developmental Process;DNA biosynthesis;DNA replication origin;Drosophila genus;Embryo;Enhancers;Event;Fertilization;gastrulation;gene network;Genes;Genetic Transcription;Genome;Goals;Hour;interest;Licensing;Mediating;Microscopy;Mitotic;Nucleosomes;Organism;origin recognition complex;Play;Pre-Replication Complex;Process;Replication Origin;Resolution;Role;Site;Testing;transcription factor;Transcription Initiation;Transcriptional Activation;transcriptome

PROJECT_TITLE: Pioneer factor activity in transcription and DNA replication

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative  This work investigates several fundamental and conserved processes used by bacteria for the acquisition of new genes and traits via horizontal gene transfer, for responses to cellular stresses, and for growth and propagation. Our focuses on the mechanisms controlling conjugation (a prevalent type of horizontal gene transfer) and the interplay between conjugative elements and bacterial viruses (bacteriophage), and between mobile genetic elements and their host cells. This work is directly related to mechanisms of bacterial survival, horizontal gene transfer, and competition between selfish DNA elements.

PI_NAMEs: GROSSMAN, ALAN D (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Affect;Antibiotic Resistance;Bacillus subtilis;Bacteria;Bacterial Genome;Bacteriophages;biological adaptation to stress;Biology;Cell Cycle;Cell Physiology;Cells;Cellular Stress;Chromosomes;Development;DNA biosynthesis;driving force;Elements;Environment;Event;Evolution;fitness;Frequencies;Gene Expression;Gene Transfer;Genes;Genome;Gram-Positive Bacteria;Growth;Horizontal Gene Transfer;Human Microbiome;interest;Life Cycle Stages;Mediating;Metabolic;microbial;Mobile Genetic Elements;pathogenic bacteria;Phenotype;Plasmids;Population;Prevalence;Process;Prokaryotic Cells;Regulation;response;Selfish DNA;Skin;Symbiosis;Tetracycline Resistance;trait;Virulence;Virus;Visualization;Work

PROJECT_TITLE: Mechanisms and regulation of replication, the cell cycle, gene expression, and horizontal gene transfer in prokaryotes, focusing on Bacillus subtilis.


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Racial and Ethnic Minority Health Research

PI_NAMEs: AZMI, ASFAR S (contact)

PROJECT_TERMS: African American;African American population;Anatomy;base;Benchmarking;Biological;Biological Markers;Cancer Center;Cancer Center Support Grant;cancer health disparity;cancer therapy;cancer type;Catchment Area;chemotherapy;Classification;Clinic;Clinical;Clinical Drug Development;Clinical effectiveness;Clinical Investigator;clinical translation;clinical trial enrollment;Clinical Trials;clinically relevant;Collaborations;Communities;Conduct Clinical Trials;Disparity;Dose;Drug Combinations;Drug Design;drug development;drug discovery;early phase trial;effectiveness validation;Enrollment;Family;follow-up;Funding;Genetic;Genetic Transcription;genomic biomarker;genomic profiling;Goals;high throughput screening;Immunologic Markers;improved;Incidence;Industry;Institution;interest;International;Intervention;Laboratories;Laboratory Finding;Lead;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;member;Michigan;Minority Groups;Mission;Molecular;molecular imaging;molecular marker;multidisciplinary;NCI Center for Cancer Research;New Agents;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Nuclear;Pathway interactions;patient oriented;Patients;Peer Review;personalized medicine;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacodynamic biomarker;pharmacokinetics and pharmacodynamics;Phase;phase 2 study;Phase II Clinical Trials;phase II trial;phase III trial;Population Study;Prediction of Response to Therapy;Process;programs;psychosocial;Publishing;racial difference;Research;Research Personnel;Research Project Grants;response;Schools;Scientist;Signal Pathway;small molecule libraries;Stromal Cells;Stromal Neoplasm;structural biology;Testing;Therapeutic;Therapeutic Agents;Toxic effect;Traditional Medicine;Translating;translational cancer research;translational study;treatment response;treatment trial;tumor;Tumor Biology;Tumor Markers;tumor metabolism;tumor microenvironment;Tumor-infiltrating immune cells;Universities;Work

PROJECT_TITLE: Molecular Therapeutics


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Pediatric;Prevention;Substance Misuse;Underage Drinking

PI_NAMEs: LIPPERMAN-KREDA, SHARON  (contact)

PROJECT_TERMS: 20 year old;Adult;Affect;Age;age related;Alcohol abuse;alcohol availability;Alcohol consumption;alcohol related problem;Alcoholic beverage heavy drinker;Back;Behavior;behavior influence;Belief;California;Characteristics;college;drinking;drinking behavior;Ecological momentary assessment;follow-up;Goals;Heavy Drinking;Home;Hour;Impulsivity;Intervention;Legal;legal drinking age;Life;Location;Measures;Outcome;Parents;Persons;Prevention;Prevention approach;preventive intervention;Process;Research;response;Risk;Role;Sampling;Shapes;social;Social Planning;Specific qualifier value;Supervision;Surveys;System;Time;underage drinker;young adult;Youth

PROJECT_TITLE: Nighttime Drinking Contexts and Risks in Young Adult Drinkers Before and After Legal Drinking Age


ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Stresses such as increased heat and oxidation cause condensation of protein and RNA into aggregates which drive a universally conserved response. Following our recent discoveries that these aggregates, long thought to be toxic, are instead often adaptive, we are pursuing an understanding of the novel functions and regulation of these adaptive condensates in the response to heat shock. We use integrated methods, from biochemistry to cell biology, to understand these phenomena in molecular detail, continuing our longstanding work in a budding yeast model and extending our efforts to understand physiological temperature-dependent responses in the immune system during fever.

PI_NAMEs: DRUMMOND, DAVID ALLAN (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Area;Biochemical;Biochemistry;Biological;Cell Physiology;Cells;Cellular biology;Esthesia;Eukaryotic Cell;Fever;fungus;Growth;Heat shock proteins;Heat-Shock Response;immune activation;Immune system;insight;Link;Messenger RNA;Methods;Modeling;Molecular;Molecular Chaperones;Neurodegenerative Disorders;novel;operation;oxidation;Physical condensation;Physiological;Process;Proteins;proteotoxicity;Regulation;response;RNA;Saccharomycetales;Signal Transduction;Specificity;Stress;Temperature;Work;Yeast Model System

PROJECT_TITLE: Function and Regulation of Stress-Induced Adaptive Condensates

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative: The non-canonical NF-κB signaling pathway controls a major branch of immune cell activation and drives essential biological processes including lymphoid organogenesis, B-cell maturation, osteoclast differentiation, and inflammation in mammals. This proposal examines the molecular mechanisms of non-canonical NF-kB suppression by the SIX-family transcription factors. A deeper understanding of the biochemical and cellular mechanisms of SIX proteins revealed by this work will lead to a greater understanding of the innate and adaptive immune system that controls human infectious disease and will reveal new therapeutic opportunities promoting resolution of chronic inflammation.

PI_NAMEs: ALTO, NEAL MATHEW (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: Acute;Adaptive Immune System;Address;Adult;B-Lymphocytes;Bacterial Infections;Biochemical;Biochemistry;Biological;Biological Process;Cell Differentiation process;Cell Lineage;Cell Maturation;cell type;Cells;chemokine;ChIP-seq;Chronic;chronic inflammatory disease;combat;Communicable Diseases;Complex;cytokine;Cytoprotection;Dangerousness;Data;design;Development;Developmental Gene;Enterobacteria phage P1 Cre recombinase;Environment;Evaluation;Event;Exposure to;Family;Functional disorder;Gatekeeping;Gene Expression;Gene Expression Regulation;gene function;gene network;Gene Silencing;Genes;genetic corepressor;Genetic Transcription;genome-wide;Glean;Goals;Gram-Negative Bacterial Infections;Hematopoietic;Homeobox;Homeodomain Proteins;Human;Human Biology;human disease;IL8 gene;Immune;immune activation;Immune system;immune system function;Immunologics;Immunology;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune System;innovation;insight;Knockout Mice;Link;LoxP-flanked allele;Lymphoid;Mammals;Mediating;microbial;model organism;Modeling;Modernization;Molecular;Morbidity - disease rate;mouse model;Mus;new therapeutic target;NF-kappa B;NFKB Signaling Pathway;novel;novel therapeutics;Organ;Organism;Organogenesis;Osteoclasts;pathogen;pathogenic bacteria;pathogenic microbe;Pathogenicity;Pathway interactions;Pattern;persistent bacterial infection;Physiological;Play;Pluripotent Stem Cells;programs;promoter;protein activation;protein expression;protein function;Proteins;reconstitution;recruit;Regulation;Regulatory Pathway;Resolution;response;Role;Signal Pathway;Signal Transduction;Site;Stress;System;Testing;Therapeutic Intervention;tissue injury;Tissues;TNF gene;transcription factor;transcriptome sequencing;Transgenic Mice;Work

PROJECT_TITLE: Resolution of Inflammation by the SIX-family Transcription Factors

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Dental, Oral, and Craniofacial Disease;Depression;Fibromyalgia;Headaches;Mental Health;Migraine;Neurosciences;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: SAN ANTONIO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Interoception is the sense of the physiological condition of the body and critical for maintaining homeostasis and regulating cognitive and emotional processes. Interestingly, vagal stimulation (major interoception input) modulates intractable chronic pain in patients. Lack of understanding about neurobiological mechanisms whereby vagal activity modulates chronic pain poses a significant hurdle for improving chronic pain management through the regulation of interoceptive inputs. Here, we focus on studying neural mechanisms of vagal modulation in a mouse model of temporomandibular disorders (TMD). TMD are the most prevalent orofacial pain conditions that involve the temporomandibular joint (TMJ), chewing muscles, and associated head and neck musculoskeletal structures and patients with TMD suffer from myofascial pain, limited mandibular motion, and TMJ sounds and the prevalence among U.S. adults is about 25% who experiencing TMD at least once in their lifetime and among them over 35 million suffer from TMD pain and resulting severe psychosocial and economic burden is more than $60 billion per year. Here, we will study functional neural mechanisms of interoception inhibiting pain. Our central hypothesis is that vagal interoceptive circuits intersect with peripheral and central nociceptive pathways to inhibit pain from TMJ.

PI_NAMEs: CHUNG, MAN-KYO ;KIM, YU SHIN  (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Ablation;Absence of pain sensation;Address;Adult;Affective;Anxiety;Arthralgia;Attenuated;Brain;Brain region;Cell Nucleus;chronic pain;chronic pain management;chronic painful condition;Cognitive;comorbidity;Data;designer receptors exclusively activated by designer drugs;diphtheria toxin receptor;Dopamine;Dopamine Antagonists;dopaminergic neuron;Economic Burden;Electric Stimulation;emotion regulation;Emotional;experience;FDA approved;Fibromyalgia;Genetic;Genetic Recombination;Head and neck structure;Health;Homeostasis;Human;Image;improved;in vivo;Inflammation;Injections;Interoception;joint inflammation;Mandible;Mastication;Mediating;Mental Depression;Migraine;Modeling;Mood Disorders;Motion;mouse model;Mus;Muscle;Musculoskeletal structure;Myofascial Pain Syndromes;Nerve;neural;neural circuit;neurobiological mechanism;neurochemistry;neuromechanism;Neurons;Nociception;novel;opioid epidemic;optogenetics;Orofacial Pain;Outcome;Pain;pain behavior;pain inhibition;Pain Management Method;pain processing;pain signal;parabrachial nucleus;Pathway interactions;Patients;Peripheral;Physiological;Population;Presynaptic Terminals;Prevalence;Process;psychosocial;Regulation;Reporting;Role;Seizures;Signal Transduction;sound;Source;Spinal Cord;Structure of trigeminal ganglion;Temporomandibular Joint;Temporomandibular joint disorder pain;Temporomandibular Joint Disorders;temporomandibular pain;Testing;Tissues;transmission process;Trigeminal System;vagus nerve stimulation;Vagus nerve structure;Work

PROJECT_TITLE: Functional peripheral and central vagal neural circuits of interoception inhibiting pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Public Health Relevance Statement Determining the genetic factors underlying human disease will support needed development of therapeutics and interventions. A critical step toward this is identifying the biological mechanisms and target genes that disease-associated genetic loci perturb, especially considering that most disease loci are not within the boundaries of any known gene. This proposal describes an integrative approach leveraging functional data to determine the target genes, cell types, and pathways affected by both rare and common genetic variation in the human population.

PI_NAMEs: BATTLE, ALEXIS  (contact)

PROGRAM_OFFICER_NAME: KRASNEWICH, DONNA M

PROJECT_TERMS: Adult;Affect;Biological;Cell Differentiation process;cell type;Chromosome Mapping;Complement;Complex;Computer software;Data;Development;Disease;Disease Progression;disorder risk;Environment;Evaluation;Exclusion;Frequencies;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Risk;genetic variant;Genetic Variation;Genome;genome sequencing;genomic locus;Heritability;Human;human disease;improved;Individual;Intervention;Link;Methods;Modeling;novel;Pathogenicity;Pathway interactions;Patients;Population;Population Genetics;Population Study;public health relevance;Quantitative Trait Loci;Rare Diseases;rare variant;Research;Resources;risk variant;Series;single-cell RNA sequencing;Statistical Methods;therapeutic development;Time;time use;Tissue Sample;Tissues;transcriptome sequencing;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Modeling the dynamicimpact of rare and common genetic variation on gene expression anddisease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-W(07)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: BEEBE-DIMMER, JENNIFER L (contact)

PROJECT_TERMS: Acceleration;Address;Admixture;Adult;Affect;African American;American;analytical method;Arabs;Area;Automobile Driving;Behavioral;biomarker discovery;Cancer Center Support Grant;cancer diagnosis;cancer epidemiology;cancer health disparity;cancer prevention;cancer risk;Cancer Survivor;Cancer Survivorship;Catchment Area;Characteristics;Childhood;Clinic;Clinical;clinical practice;clinical research site;cohort;Cohort Studies;Collaborations;Colon Carcinoma;Communication;Communication Research;Communities;community based research;comorbidity;Comprehensive Cancer Center;Custom;Data;defined contribution;design;Development;Diagnosis;Discrimination;Disease Progression;Disparity;disparity elimination;disparity reduction;eHealth;end of life outcomes;Endometrial Carcinoma;epidemiology study;Epigenetic Process;ethnic diversity;Ethnic Origin;Evidence based intervention;experience;family genetics;Family member;Funding;Future;gender minority group;Genetic;Goals;Grant;Health;health equity;heritability pattern;high risk;high risk population;Immunity;improved;Incidence;Individual;Inflammation;Institution;interest;Intervention;Investigation;Lesbian Gay Bisexual Transgender;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;medically underserved;member;Metabolic syndrome;metropolitan;Michigan;Minority;Minority Groups;Mission;Molecular;Molecular Epidemiology of Cancer;mortality;neoplasm registry;novel;Obesity;Onset of illness;Outcome;outreach;Participant;patient-clinician communication;Patient-Focused Outcomes;Patients;Peer Review;Physical activity;Physicians;Population;population based;population health;Population Heterogeneity;Population Study;preclinical study;Prognosis;programs;provider behavior;psychosocial;Publishing;Quality of Care;Race;racial bias;racial disparity;racial diversity;recruit;Reduce health disparities;Research;Research Project Grants;Resources;Risk;Risk Behaviors;Risk Factors;Risk Reduction;risk stratification;Role;Rural Minority;Rural Population;Schools;screening;SEER Program;Sexual and Gender Minorities;sexual minority group;Site;Smoking;social;Survivors;survivorship;Susceptibility Gene;symptom management;System;Targeted Research;Technology;Testing;theories;treatment choice;tumor;Underserved Population;United States;Universities;Work

PROJECT_TITLE: Population Studies and Disparities Research


NIH_SPENDING_CATS: Cancer;Genetics;Infectious Diseases;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: The goal of this project is to expand our understanding of the Moloney murine leukemia virus – prototype of the simple mammalian retroviruses, and a model for the human retroviruses HTLV-1 and HIV 1 – and of the host regulation of viral DNA expression. We are especially focused on characterizing the mechanism of action of specific host factors that we have identified that restrict virus expression in embryonic cell types. The work will reveal new aspects of the host machinery that can induce and maintain the latent status of integrated proviral DNAs and will inform new approaches to treatment of viral leukemias and AIDS.

PI_NAMEs: GOFF, STEPHEN PAINE (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acetylation;Acquired Immunodeficiency Syndrome;Affect;Anti-viral Therapy;Binding;Binding Sites;Biochemical;Biological Process;Cell Differentiation process;Cell Line;cell type;Cells;Characteristics;Chromatin;cofactor;Complex;Cullin Proteins;Development;DNA;DNA Binding;DNA-Binding Proteins;Elements;Embryo;embryo cell;Embryonic Development;embryonic stem cell;Epigenetic Process;Event;experimental study;Family;Funding;Gene Expression;Gene Silencing;Genes;Genetic;Genome;Germ Lines;Goals;Haploid Cells;Histone Deacetylase;histone modification;HIV-1;Human;Human T-lymphotropic virus 1;Infection;Integration Host Factors;integration site;interest;knock-down;Knock-out;Maintenance;Mediating;member;Methylation;Modeling;Modification;Moloney Leukemia Virus;Monitor;Mouse Embryonic Stem Cells;Mus;novel;novel strategies;Pathway interactions;peripherin;Phosphorylation;pluripotency;Positioning Attribute;primitive cell;Proline-Specific tRNA;Property;protein complex;Protein Family;protein protein interaction;Proteins;prototype;Provirus Integration;Proviruses;Regulation;Regulatory Pathway;Repression;Retroviridae;RNA;RNA Binding;Role;SETDB1 gene;Signal Pathway;Signaling Molecule;Site;Specificity;stemness;Structure;SUMO1 gene;Testing;Transferase;TRIM Motif;ubiquitin ligase;Viral;viral DNA;viral leukemia;Virus;Work;YY1 Transcription Factor;Zinc Fingers

PROJECT_TITLE: Mechanisms of Silencing of Retroviral DNAs in Embryonic Cell Lines


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking

PROJECT_TERMS: 20 year old;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adult;adverse outcome;Affect;age effect;Aggressive behavior;alcohol availability;Alcohol consumption;alcohol measurement;alcohol use initiation;Alcohols;Behavior;Belief;California;Cannabis policy;Cannabis retail;Cities;cohort;Communities;deter alcohol use;Drug usage;emerging adult;Environment;Ethnic Origin;Ethnic Population;evidence base;Fostering;Gender;health disparity;Heavy Drinking;impaired driving performance;Knowledge;Life;Longitudinal Surveys;Marijuana;marijuana legalization;marijuana use;Marketing;Mediating;Medical;Monitor;Oregon;Performance;Persons;Pharmaceutical Preparations;Policies;Policy Maker;Population;prevent;Prevention approach;Price;Production;Psychotropic Drugs;Public Health;public policy on alcohol;Race;racial population;Recreation;recruit;reduced alcohol use;Research;Risk;Safety;Sales;sex;sexual assault;social;Source;Substance Use Disorder;Time;underage drinking;Variant;young adult;Youth

PROJECT_TITLE: Local Alcohol and Marijuana Policies, Retail Availability, and Co-Use During Adolescence and Early Adulthood


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE Antiretroviral therapy has greatly improved the lives of HIV positive patients, reducing their risk of progressing to full blown AIDS and the likelihood that they will pass the virus to their partners. However, delayed diagnosis, interruptions in treatment, or the emergence of drug resistant virus all put these patients at risk. The aim of this project is to develop a new HIV test that can be performed by an individual in their own home or other non‐clinical environment without specialist equipment. To do this we will exploit a novel molecule, found only in sharks, for the efficient detection and quantification of virus in unmanipulated samples such as blood.

PI_NAMEs: DOOLEY, HELEN M. (contact);MCDEVITT, JOHN T

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: 3-Dimensional;accurate diagnostics;Acquired Immunodeficiency Syndrome;Acute;Address;Affinity;Animals;Antibodies;Antigen-Antibody Complex;Antigens;antiretroviral therapy;Area;assay development;Binding;Biological;Biological Assay;Blood;Blood specimen;Buffers;Capsid Proteins;Cellular Phone;Clinic Visits;cloud based;Coupling;Data;Databases;Detection;detection platform;Diagnosis;Diagnostic;diagnostic platform;diagnostic technologies;Diagnostic tests;diagnostic tool;digital;Dissociation;Drops;Drug resistance;drug resistant virus;Early Diagnosis;Environment;Epidemiology;Epitopes;Equipment;Feedback;Fingers;Generations;Harvest;Health Personnel;Healthcare;HIV;HIV Core Protein p24;HIV Infections;HIV Seropositivity;HIV-1;Home;home test;Human;Human immunodeficiency virus test;imaging system;Immunize;improved;Individual;Interruption;Laboratories;Libraries;Link;microchip;Microfluidics;Microspheres;minimally invasive;Monitor;Monoclonal Antibodies;novel;Nurses;Outcome;Patients;Performance;Peripheral Blood Lymphocyte;Phase;point of care;Porosity;Privatization;programs;Proteins;prototype;Reader;Reagent;Recombinants;repository;Reproducibility;Resources;response;Risk;Sampling;Secure;Self Administration;self testing;sensor;Sepharose;Serology test;Shark;Specialist;Specificity;Surface;System;Tablets;Target Populations;Technology;Testing;thermostability;Time;Training;Validation;Viral;Viral Load result;virology;Virus;Weight

PROJECT_TITLE: Self-test HIV diagnostics utilizing structurally novel, shark-derived binding domains


ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Technological advances have fueled the ascent of personal genomics and the promise of precision medicine. To unlock this potential, we must first understand how the environmental and genetic interactions unique to each individual contribute to variation in disease-related traits. This is the theme of my research program, which I advance using innovative strategies to dissect complex trait variation; the ultimate goal is prediction of an individual’s disease risk from his or her genome sequence.

PI_NAMEs: AYROLES, JULIEN  (contact)

PROJECT_TITLE: A path to personalized phenotypic prediction: unlocking the context-dependency of allelic effects


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunotherapy;Kidney Disease;Rare Diseases

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Unique genetic alterations promote a characteristic pseudo-hypoxic response and metabolic defects in kidney cancer cells. How these cell intrinsic mechanisms affect immune cell function and therapeutic resistance in the tumor microenvironment (TME) is not understood. This study will highlight a novel organoid model of kidney cancer and demonstrate the pseudo-hypoxic contributions on the TME to uncover new strategies for modulating and improving anti-tumor immune responses.

PI_NAMEs: WOLF, MELISSA M (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: 3-Dimensional;Address;aerobic glycolysis;Affect;anti-tumor immune response;Antigen-Antibody Complex;Antitumor Response;Area;Cancer Biology;cancer cell;CD8B1 gene;Cell Communication;Cell Energetics;Cell Hypoxia;Cell Line;Cell Physiology;Cells;Cellular Metabolic Process;Characteristics;Clear cell renal cell carcinoma;Complement;Complex;Consumption;Data;Defect;Dependence;Development;Disease Management;Environment;Event;Fine needle aspiration biopsy;Functional impairment;Genetic;Genetic Transcription;Glucose;Growth;Homeostasis;Human;Hypoxia;Hypoxia Inducible Factor;Immune;immune cell infiltrate;immune checkpoint blockade;Immune Evasion;immune function;Immunologic Surveillance;Immunooncology;Immunotherapy;Impairment;improved;in vivo;in vivo Model;Infiltration;Inflammatory;Investigation;Knock-out;Learning;Link;Lymphocyte Suppression;Malignant Neoplasms;Mediating;Metabolic;Metabolism;mitochondrial metabolism;Modality;Modeling;Mus;Mutation;Myelogenous;Myeloid-derived suppressor cells;normoxia;novel;Nutrient availability;Organoids;Oxygen;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Population;Population Heterogeneity;recruit;Renal Carcinoma;Resistance;response;Role;Shapes;Signal Pathway;Signal Transduction;single cell analysis;single nucleus RNA-sequencing;T-Lymphocyte;Testing;therapy resistant;Time;tool;transcription factor;transcriptome;translational study;tumor;Tumor Immunity;tumor metabolism;tumor microenvironment;tumor progression;Tumor-associated macrophages;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;Ubiquitination;VHL gene;VHL protein;Work

PROJECT_TITLE: Pseudo-hypoxic contributions to the tumor microenvironment in kidney cancer


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Narrative Amyotrophic lateral sclerosis is a devastating neurodegenerative disease without cures. Recent progress has revealed stress granules as the cellular locales of the formation of protein aggregates and disease development, renewing efforts to understand the molecular basis of pathogenesis. We will use biophysical experiments, simulations and theory to understand the physical principles underlying the formation of protein aggregates in stress granules overcoming critical bottlenecks for combatting the disease.

PI_NAMEs: MITTAG, TANJA  (contact);PAPPU, ROHIT V

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Acceleration;Adhesives;Affinity;Aging;Amyotrophic Lateral Sclerosis;arm;Aromatic Amino Acids;Automobile Driving;Behavior;Biochemical;Biophysics;Brain;crosslink;Cytoplasm;Degenerative Disorder;design;Development;Disease;Disease Progression;disease-causing mutation;driving force;effective therapy;Elements;experimental study;Genetic;Goals;Heterogeneous-Nuclear Ribonucleoproteins;Hydrogen Bonding;insight;interest;Investigation;Life;Link;Liquid substance;Locales;Location;macromolecule;Mediating;member;Membrane;Microscopic;Modeling;Molecular;motor neuron degeneration;mutant;Mutation;Nature;Neurodegenerative Disorders;Nodal;Organelles;Pathogenesis;Pathologic;Pattern;Phase;Phase Transition;Physical condensation;Physics;Polyribosomes;Positioning Attribute;predictive modeling;Process;protein aggregation;protein TDP-43;Proteins;RNA;RNA Recognition Motif;RNA-Binding Proteins;Role;scaffold;Side;simulation;Solid;solid state;Solvents;Spinal Cord;Stress;stress granule;structural determinants;Structure;System;TAF15 gene;Temperature;Testing;theories;Therapeutic;Therapeutic Intervention;Translations;Vertebral column;Work

PROJECT_TITLE: Understanding the sequence and structural determinants of phase behavior of ALS-causing proteins

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative:  The ultimate goal of research on neurodegenerative disorders is to develop therapeutics to slow disease pro- gression and provide effective treatment for patients. This proposal aims to develop new statistical approaches to integrate complementary sources of information from genomic measures, brain imaging, blood biomarkers, digital markers, and early clinical signs in an effort to characterize personalized disease susceptibility, progres- sion, diagnosis, and treatment responses, and thereby inform the discovery of optimal therapies and the design of clinical trials.

PI_NAMEs: WANG, YUANJIA  (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Address;Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;analytical method;Autopsy;Back;Behavioral;Biological Markers;Biology;biomarker discovery;Blood;Brain;Brain imaging;Cellular Phone;Cessation of life;Clinical;clinical biomarkers;Clinical Data;clinical decision-making;clinical diagnosis;clinical diagnostics;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Design;cognitive task;cohort;Cohort Studies;Collaborations;Communities;comorbidity;Data;data space;Degenerative Disorder;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic criteria;Differential Equation;digital;Digital biomarker;digital models;digital phenotyping;Dimensions;Disease;disease model;Disease Progression;Disease susceptibility;dynamic system;Early Diagnosis;Early Intervention;effective therapy;Ensure;Environmental Risk Factor;Event;experimental study;Face;Family;Family history of;Family member;Funding;generative models;Genetic;Genetic Counseling;Genetic Risk;Genomics;Goals;Health;Health Status;Healthcare Systems;Heritability;Heterogeneity;Hospitals;improved;Individual;International;Joints;Laboratories;Learning;Liquid substance;machine learning method;Manuscripts;Measurement;Measures;Methods;Modeling;Modernization;multimodal data;Nervous System Disorder;Neurodegenerative Disorders;neuroimaging;Neurologist;neuropathology;neuropsychiatry;Non-linear Models;Nonlinear Dynamics;novel;Observational Study;optimal treatments;Parkinson Disease;Participant;Pathologic;Pathology;patient variability;Patients;Pattern;personalized medicine;Persons;Phenotype;Police;Policies;Population;Population Heterogeneity;pre-clinical;precision medicine;Precision Medicine Initiative;predictive modeling;Process;progression marker;Property;Publishing;Recording of previous events;Records;recruit;Research;Research Personnel;Research Priority;response;Risk;risk prediction;semiparametric;simulation;Site;Source;Space Models;specific biomarkers;Speech;Staging;statistical learning;Statistical Methods;statistics;Surveys;Symptoms;System;Testing;theories;Therapeutic;Time;timeline;Translating;Translational Research;treatment response;trial design;Universities;Walking;Work

PROJECT_TITLE: Statistical Methods for Integrating Mixed-type Biomarkers and Phenotypes in Neurodegenerative Disease Modeling

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: THOMPSON, HAYLEY S. (contact)

PROJECT_TERMS: Address;Advocate;anti-cancer research;Area;Basic Science;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer health equity;cancer risk;Cancer Survivor;Caregivers;Catchment Area;Characteristics;Cities;Clinical Sciences;Collaborations;Communities;community engagement;Community Outreach;community partners;Compassion;County;Data;Development;Disparity;Education;Ensure;Ethnic Origin;Evidence based practice;Exclusion;Home;Infrastructure;Intervention;knowledge integration;Lead;Leadership;Link;Malignant Neoplasms;Michigan;Mission;Molecular;molecular imaging;Monitor;Neighborhoods;outreach;Phase;Policies;Population;Population Sciences;Population Study;programs;Race;Research;Research Institute;Research Personnel;Research Priority;Risk Factors;rurality;Science;Source;surveillance strategy;System;Therapeutic Studies;Tumor Biology;tumor microenvironment;Underserved Population;Work

PROJECT_TITLE: Community Outreach and Engagement


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly heritable neurodevelopmental disorder, most often identified at school-age after impairment is present; therefore, early precursors to the development of ADHD need to be identified as a first step to developing early interventions aimed at preventing the disorder. This K23 career development award will aid in establishing Dr. Joseph as an independent physician-investigator equipped to investigate neonate and infant markers of inattention to address the intergenerational transmission of ADHD. Research suggests that the development of attention can be influenced by the parent’s behaviors, although little is known about the developmental trajectory in offspring of parents with ADHD; thus, the knowledge gained from prospectively following neonates, at high and low familial risk for ADHD, to toddlerhood will inform our understanding of (1) the clinical predictive utility of early indices of attention, (2) the influence of parenting behavior on offspring attention that may ultimately serve as an intervention target, and (3) when to intervene to promote the development of attention.

PI_NAMEs: JOSEPH, HEATHER MARIE (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 3 year old;Address;Adult;Affect;Age;Age Months;Age Years;Attention;Attention deficit hyperactivity disorder;attentional control;Behavior;behavioral outcome;Birth;career;Child;Child Behavior;Child Rearing;Childhood;clinical predictors;Cognitive;cognitive development;cognitive function;computerized;course development;Data;Development;developmental disease;Dimensions;Disease;Early identification;Early Intervention;Economic Burden;Education;Environment;Equation;Evaluation;executive function;Fathers;Foundations;functional improvement;functional outcomes;gaze;Goals;habituation;Heritability;high risk;Impaired health;Impairment;inattention;indexing;Individual;infancy;Infant;Infant Development;Infrastructure;insight;Institutionalized Child;intergenerational;Intervention;joint attention;Joints;K-Series Research Career Programs;Knowledge;Length;Life;Literature;longitudinal analysis;longitudinal course;Measurement;Measures;Mental disorders;Mentors;Mentorship;National Institute of Mental Health;Neonatal;neonatal period;neonate;neurobehavioral;neurodevelopment;Neurodevelopmental Disorder;Neurologic;novel;Nursery Schools;offspring;Outcome;parental influence;Parents;Patient Recruitments;Performance;Physicians;Predictive Value;prevent;prospective;Reaction Time;Reporting;Research;Research Personnel;Research Proposals;Resources;Risk;risk mitigation;sample fixation;School-Age Population;Schools;Seminal;Signal Transduction;skills;social;Social Environment;Specialist;Statistical Methods;Stimulus;Symptoms;Testing;Time;Toddler;Training;transmission process;Universities;Visual;Visual attention;Work

PROJECT_TITLE: Early Signals of Inattention in Neonates and Infants at Familial Risk for ADHD


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PI_NAMEs: CAETANO, RAUL  (contact)

PROJECT_TERMS: Adult;Alcohol consumption;Alcohols;California;Cannabis;Cannabis policy;Cannabis retail;Cities;Communities;Community based prevention;Consumption;Data;Data Analyses;density;Empirical Research;Environment;ethnic disparity;ethnic minority population;evidence base;Exposure to;Face;Frequencies;Growth;health disparity;Heavy Drinking;Hispanic Populations;implementation process;Incidence;Intervention;Knowledge;Legal;Licensing;Link;longitudinal analysis;marijuana use;Marketing;Not Hispanic or Latino;Pattern;Policies;Population;Population Group;Prevalence;Prevention approach;preventive intervention;public policy on alcohol;Recreation;Reporting;Risk Factors;Sales;Science;Smoke;Social Problems;Source;Surveys;System;Taxation;Telephone;Testing;theories;trafficking;vaping;Variant

PROJECT_TITLE: Post-Legalization Regulatory Policies, Alcohol and Cannabis Co-Use, and its Consequences among Whites and Hispanics in California


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Poor postnatal growth is a common problem among extremely preterm infants that is associated with adverse neurodevelopmental outcomes. The proposed research is relevant to public health because it seeks to understand how bacteria within the intestinal microbiome of preterm infants support postnatal growth. This work has potential to lead to novel approaches to optimize growth and development of preterm infants.

PI_NAMEs: YOUNGE, NOELLE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Adult;Bacteria;Birth;Body System;Brain;Collection;Communities;critical developmental period;Data;Development;experience;experimental study;extreme prematurity;Failure;Germ-Free;Gestational Age;Gnotobiotic;Goals;Growth;Growth and Development function;gut colonization;gut microbiome;high risk population;Hormones;Human;Immune response;Impairment;infancy;Infant;infant nutrition;Insulin-Like Growth Factor I;Intervention;Knowledge;Laboratories;Length;Leptin;Mediating;Mediator;member;Metabolism;microbial;microbial colonization;microbial community;microbiome;Modeling;Molecular;mouse model;Mus;Neonatal;neonatal mice;next generation;novel strategies;Nutrient;nutrition;Nutritional Support;Outcome;Phase;Phenotype;Physiology;Play;postnatal;postnatal period;Premature Infant;prevent;Preventive therapy;probiotic therapy;Public Health;Regulation;Reproducibility;Research;Risk;Role;Testing;tool;Translating;transmission process;Transplantation;Weight;Weight Gain;Work

PROJECT_TITLE: Bacterial mediators of postnatal growth in preterm infants

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BRONX

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FORDHAM UNIVERSITY

PHR: 8. PROJECT NARRATIVE Hispanic-Serving Institutions are institutions of higher education that prioritize supporting low-socioeconomic position students of color through their educational experiences; these institutions’ efforts may also promote health among diverse young adult populations. The design of this study allows us to longitudinally examine the economic and educational determinants of cardiometabolic health among diverse emerging adults, which are not yet comprehensively understood. Our study will help identify modifiable risk and protective factors from the economic and education sectors that could be targets for interventions to promote positive health behaviors and reduce risk of negative cardiometabolic health outcomes among emerging adults.

PI_NAMEs: COHEN, ALISON ;HOYT, LINDSAY TILL (contact)

PROGRAM_OFFICER_NAME: REIS, JARED P

PROJECT_TERMS: Academic support;Address;Adult;Affect;Affinity;Age;aged;Asian;Behavior;Behavioral;Binge Eating;Biological;Black race;Blood Pressure;Body mass index;California;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular health;career;Cellular Phone;Chronic Disease;Classification;college;Color;Complex;Country;COVID-19 pandemic;Data;Data Reporting;design;Development;diaries;Diet;Disease Outcome;disorder prevention;Eating Disorders;economic determinant;Economic Factors;Economics;Education;emerging adult;emerging adulthood;Employment;Enrollment;Environment;Ethnic Origin;experience;Financial Hardship;Food;Gender;Gender Identity;graduate school;Green space;Health;Health behavior;health determinants;health inequalities;Health Promotion;Heart Diseases;High Prevalence;high school;higher education;Hispanic;Hispanic-serving Institution;Household;Housing;Hypertension;Incidence;Income;Individual;Institution;Intervention;Joints;Latinx;Life Cycle Stages;Link;Longitudinal cohort;Longitudinal cohort study;low socioeconomic status;Marketing;Measures;Mediating;Mediation;Modeling;modifiable risk;novel;Obesity;Observational Study;older adult;Outcome;Overweight;Pathway interactions;Patient Self-Report;Perception;person centered;Persons;Phase;Physical activity;Physical environment;Population;population health;Population Heterogeneity;protective factors;Race;racial identity;recruit;Reduce health disparities;Reporting;Research;Risk;Risk Factors;Risk Reduction;Safety;Sampling;Security;sedentary lifestyle;Services;Shapes;Sleep;Smoking;social culture;Social Environment;social health determinants;Social status;Social support;Socioeconomic Status;socioeconomics;Stress;stressor;Student recruitment;Students;Surveys;Teenagers;Time;undergraduate student;United States;university student;Weight;Weights and Measures;young adult

PROJECT_TITLE: The 3E Study: Economic and Educational Contributions to Emerging Adult Cardiometabolic Health

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_NAME: WAYNE STATE UNIVERSITY

PI_NAMEs: UBERTI, JOSEPH P. (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;Award;Basic Science;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer health disparity;Catchment Area;Clinical Investigator;Clinical Sciences;Clinical Trials;community engagement;community partners;Development;disparity reduction;Evaluation;Extramural Activities;Faculty;Faculty Recruitment;Funding;Funding Agency;Future;Goals;Grant;Immunology;Immunotherapy;innovation;Institution;Intervention Studies;investigator-initiated trial;Investments;Leadership;Measures;member;metabolomics;Peer Review;Physicians;Pilot Projects;Population Sciences;Principal Investigator;Process;programs;Publications;Publishing;recruit;Research;Research Personnel;Research Project Grants;Risk;Role;Scientist;Secure;Strategic Planning;Strategic vision;success;survivorship;trend;tumor metabolism

PROJECT_TITLE: Developmental Funds


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative After someone’s heart stops beating (“cardiac arrest”), chest compressions (“CPR”) can restart their heart. However, many patients later die from brain damage, and we lack medications to prevent this brain damage. We are targeting the immune system to help protect the brain after cardiac arrest. 2

PI_NAMEs: KIM, EDY YONG (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Address;Agonist;Anti-Inflammatory Agents;biobank;Bioinformatics;Brain;Brain Injuries;Cardiac;Cardiopulmonary Resuscitation;Cause of Death;Cells;checkpoint receptors;Chest;Circulation;Clinical;clinically relevant;cohort;Collaborations;Critical Care;Cryopreservation;cytokine;Data;Enrollment;Goals;Heart;Heart Arrest;Hospitalization;Immune;immune checkpoint;immune function;Immune response;Immune system;Immune Targeting;Immunology;Immunophenotyping;immunoregulation;improved;In Vitro;Inflammation;Inflammatory;Inflammatory Response;Injury;Interferon Type II;Interleukin-10;Intervention;Mediating;Methods;Monoclonal Antibodies;monocyte;mortality;mouse model;multidisciplinary;Mus;Natural Killer Cells;nectin;Nervous System Trauma;Neurologic;Neurological outcome;novel therapeutic intervention;out-of-hospital cardiac arrest;Outcome;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;prevent;Production;prospective;Reaction;Recombinants;Resolution;Resources;response;Resuscitation;Sepsis;single-cell RNA sequencing;Site;systemic inflammatory response;Testing;Therapeutic;therapeutic candidate;Therapeutic Intervention;therapeutic target;Time;Validation

PROJECT_TITLE: Resolution of inflammation after cardiac arrest


NIH_SPENDING_CATS: Cancer

PROJECT_TITLE: Shared Resource Management


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Orphan Drug;Ovarian Cancer;Pancreatic Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative Ovarian cancer and pancreatic adenocarcinoma (PDAC) are two of the most lethal cancers and notoriously resistant to standard therapies. We have developed a dual-domain therapeutic, S2/IAPinh, that selectively delivers a drug cargo into cancer cells and induces enhanced tumor cell death. Recent experimental evidence suggests that S2/IAPinh, while far more effective than IAPinh alone, is insufficient to eradicate the tumors as a monotherapy. Here, we will explore a number of new avenues for successful combination cancer therapies.

PI_NAMEs: HAWKINS, WILLIAM G;SPITZER, DIRK M. (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Abraxane;Address;Anticholesteremic Agents;Apoptosis;cancer cell;Cancer Patient;cancer therapy;carcinogenesis;CASP3 gene;Caspase;Cell Death;Cell Line;Cell Survival;Cells;chemical conjugate;Chemicals;chemotherapy;Cholesterol;Clinical;combination cancer therapy;cytotoxic;cytotoxicity;Data;Development;DNA Damage;Dose;drug candidate;Drug Combinations;Drug Delivery Systems;drug development;Drug Efflux;Drug Formulations;Drug Kinetics;Drug resistance;effective therapy;efficacy evaluation;Enhancers;Epithelial ovarian cancer;Evaluation;Excipients;Foundations;Frequencies;gemcitabine;genetic signature;Goals;Gold;Grant;Human;improved;In Vitro;in vivo;Inhibition of Apoptosis;inhibitor;inhibitor therapy;inhibitor-of-apoptosis protein;innovation;Lead;Ligands;Link;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Maximum Tolerated Dose;Mediating;Mitochondria;mouse model;neoplastic cell;novel;novel drug combination;novel therapeutics;Ovarian;Paclitaxel;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patient-Focused Outcomes;Patients;performance tests;Pharmaceutical Preparations;Pharmacodynamics;Pharmacotherapy;pre-clinical;Pre-Clinical Model;preclinical development;promoter;Regimen;Resistance;resistance mechanism;response;Route;sigma-2 receptor;Signal Transduction;small molecule;Sodium Chloride;Specificity;standard of care;Stress;systemic toxicity;targeted cancer therapy;targeted treatment;Testing;Therapeutic;therapy resistant;TNF gene;Toxic effect;Treatment Protocols;triple-negative invasive breast carcinoma;tumor;tumor eradication;uptake;Variant;Work;x-linked inhibitor of apoptosis protein

PROJECT_TITLE: Preclinical development of the novel inhibitor of apoptosis proteins S2/IAPinh for cancer therapy

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BELTSVILLE

ORG_NAME: PACIFIC INSTITUTE FOR RES AND EVALUATION

PI_NAMEs: SALTZ, ROBERT F. (contact)

PROJECT_TERMS: active lifestyle;Acute;Adult;Age Years;aged;Aging;alcohol and other drug;alcohol availability;Alcohol consumption;alcohol screening;alcohol use disorder;Alcohols;Attention;baby boomer;California;Censuses;Characteristics;Chronic;chronic pain;Clinical;cohort;Communities;Consumption;Dependence;design;directed attention;drinking;Drug Prescriptions;Event;falls;follow-up;Future;General Population;Generations;hazard;hazardous drinking;Health;holistic approach;human old age (65+);human very old age (85+);Income;Individual;Injury;Intervention;Lead;Life;Life Expectancy;Life Experience;life span;Life Style;Longevity;Low income;Low Prevalence;member;Mental Health;Modeling;older adult;Pattern;physical conditioning;Physical environment;Physicians;Population;Predisposition;prevent;Prevention approach;preventive intervention;Questionnaires;Recreation;recruit;Religiosity;Research;Research Personnel;Retirement;Risk;Sampling;Self Medication;Shapes;Social Environment;Stratification;Surveys;Time;trend

PROJECT_TITLE: Transitions and Alcohol Use in the Later Lifespan:  Environmental and Individual-level Influences


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project narrative Given the complexity and multimodal nature of the input to the child, learning language should be a challenging task, but most young infants proceed in achieving language competence with enormous speed. We hypothesize that the alignment and use of multimodal cues, including touch, in the input may play a key role in this achievement and explore this hypothesis in a series of experiments. The primary translational signiﬁcance of this work is the potential to provide insights into language learning mechanisms, which ultimately could impact treatment protocols and interventions or parent-training programs with high-risk infants consistent with the mission of NIH.

PI_NAMEs: BOROVSKY, ARIELLE  (contact);SEIDL, AMANDA H

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Achievement;Affect;age effect;Attention;Auditory;autism spectrum disorder;Behavioral;Caregivers;Child;Child Rearing;Clinical;clinically significant;Competence;Cueing for speech;Cues;Deceleration;design;Development;Early Intervention;Environment;experience;experimental study;Exposure to;Goals;Hearing;Heart Rate;high risk;high risk infant;improved;Infant;insight;Intervention;Knowledge;Label;Language;Language Delays;Language Development;Language Disorders;language outcome;Language Therapy;Learning;lexical;Linguistics;low socioeconomic status;Maps;mathematical ability;Measures;Mediating;Mission;Modality;multimodality;multisensory;Nature;Oral;parenting intervention;phonology;Physiological;Play;Research;Risk;Role;Semantics;sensor;Sensory;sensory input;sensory system;Series;Siblings;Signal Transduction;Smell Perception;social;sound;Speech;Speed;Stream;syntax;System;Tactile;Taste Perception;Temperature;Testing;Texture;theories;Time;Toddler;Touch sensation;Training Programs;Treatment Protocols;United States National Institutes of Health;Vision;Visual;visual tracking;word learning;Work

PROJECT_TITLE: Touch to learn: How sensory cues impact word segmentation and learning

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE – RELEVANCE Increasing access to tobacco cessation medications is a key part of U.S. health policy’s strategy for reducing smoking rates, especially for smokers with low incomes. The central objectives of this project are to estimate the impact of prior authorization requirements for tobacco cessation medications in Medicaid programs on the use of cessation-related health care treatment and to understand prior authorization’s implications for disparities in the use of tobacco cessation medications and for potentially contraindicated prescriptions. The findings from this study will provide public health stakeholders with information that can be used when making decisions about whether to require prior authorization for tobacco cessation medications and, conditional on requiring prior authorization, to set up systems and rules that improve the prior authorization process for tobacco cessation medications.

PI_NAMEs: DILLENDER, MARCUS OWEN (contact)

PROGRAM_OFFICER_NAME: PRUTZMAN, YVONNE M

PROJECT_TERMS: Administrator;Advocate;Affordable Care Act;Age;Behavior;Black Populations;Characteristics;Cigarette;Colorado;cost effective;Counseling;Data;Data Set;Decision Making;design;Disparity;Drug Prescriptions;Ensure;evidence base;Grant;Health;Health Policy;Healthcare;Hispanic Populations;improved;Income;insight;Insurance;Insurance Carriers;Knowledge;Low income;Low Income Population;low socioeconomic status;Managed Care;Medicaid;National Cancer Institute;Nicotine;Patients;Pattern;Persons;Pharmaceutical Preparations;Population;prior authorization;Process;programs;Public Health;Public Policy;Recommendation;reduce tobacco use;Research;Research Priority;sex;Smoke;Smoker;Smoking;smoking cessation;System;Testing;Tobacco Use Cessation

PROJECT_TITLE: Examining the Impact of Medicaid's Prior Authorization Requirements for Tobacco Cessation Medications on Tobacco Cessation Medication Prescriptions


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: DETROIT

PI_NAMEs: SHIELDS, ANTHONY FRANK (contact)

PROJECT_TERMS: Adolescent;Cancer Center;Cancer Center Support Grant;Cancer Patient;cancer therapy;Catchment Area;Childhood;Clinical;Clinical Data;Clinical Investigator;Clinical Practice Guideline;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Trials;Code;Collaborations;Communication;Conceptions;Data;data management;Education and Outreach;Ensure;Ethics;Funding;Goals;Good Clinical Practice;Grant;Healthcare;improved;Individual;Industry;Infrastructure;Institution;Institutional Review Boards;International;Intervention Trial;Investigational Drugs;Lead;Life Cycle Stages;life span;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;member;Michigan;Minority;Minority Enrollment;Mission;Monitor;National Clinical Trials Network;Nursing Research;older adult;operation;Participant;Patient Participation;Patients;Pediatric Hospitals;Pediatric Oncology Group;Peer Review;Physicians;Policies;Preparation;Process;process improvement;programs;Protocols documentation;quality assurance;Quality Control;Quality of life;recruit;Regulation;Reporting;Research;Research Personnel;Resource Sharing;Resources;Safety;Services;Site;Specialist;symposium;System;Time;Training;Training and Education;training data;Translational Research;Universities;Vision;Woman

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE There is a critical unmet need for understanding the causes of rare neurodevelopmental disorders and to develop new precise treatments for these patients. The proposed research will evaluate how mutation in a chromatin regulator independently alters brain development and synaptic function in the brain. A secondary aim of this work is to test a novel therapeutic option for treating this disorder that could be rapidly translated to the clinic if our work is successful.

PI_NAMEs: HUNT, ROBERT F (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Adult;Anatomy;Area;autism spectrum disorder;Automobile Driving;Basic Science;Behavior;Behavioral;behavioral study;Benchmarking;Brain;Brain region;Cancer cell line;Candidate Disease Gene;Chromatin;Chromatin Remodeling Factor;Chromosome Mapping;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Complex;Data;Development;Diabetes Mellitus;Disease;DNA Sequence Alteration;dosage;Electrophysiology (science);Embryo;Engineering;Epilepsy;Event;Exhibits;Gene Expression;Gene Mutation;Genes;Genetic Risk;Genetic study;Genomics;Germ Lines;Glutamates;Heterozygote;hippocampal pyramidal neuron;Hippocampus;Human;human induced pluripotent stem cells;Immunohistochemistry;In Vitro;in vivo;Individual;Induced pluripotent stem cell derived human neuron;Intellectual functioning disability;Laboratories;life span;Literature;loss of function mutation;Malignant Neoplasms;Mediating;Memory;Memory impairment;Metformin;migration;Molecular;mouse genetics;Mus;Mutation;National Institute of Neurological Disorders and Stroke;neurodevelopment;Neurodevelopmental Disorder;Neurologic;neuronal excitability;Neurons;neurotransmission;new therapeutic target;novel;novel therapeutics;Pathologic;Pathology;Patients;Pharmaceutical Preparations;pharmacologic;Photosensitivity Disorders;Population;prevent;Proliferating;Pyramidal Cells;Reporting;Research;Series;Signal Transduction;Stem cell transplant;stem cells;Structure;Synapses;synaptic function;Testing;Therapeutic;therapeutic evaluation;Translating;Transplantation;Western Blotting;Work

PROJECT_TITLE: Bidirectional control of Chd2 haploinsufficiency

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Although the integrity of mitochondrial DNA (mtDNA) is critical for numerous cellular processes, mtDNA is the target of highly disruptive truncating mutations in over 10% of all cancers. Understanding the function of truncating mtDNA mutations has been dually impeded by a lack of experimental tools to engineer mtDNA mutations and a lack of analytical methods to study the sensitivity of mutant phenotypes to mutation dosage (i.e. heteroplasmy). Here, we propose an innovative and multidisciplinary approach that overcomes these challenges by combining a novel genetic engineering technology (the DddAtox cytosine base editor, DdCBE) with integrative computational analyses to establish the function, dosage sensitivity, and therapeutic vulnerabilities of one of the most common and underexplored genetic insults in the cancer genome.

PI_NAMEs: GAMMAGE, PAYAM ;REZNIK, EDUARD  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Affect;Alleles;analytical method;base editing;base editor;Binding;Biochemical;cancer cell;Cancer cell line;cancer genome;Cell Line;Cell Physiology;cell type;Cells;Code;colon cancer cell line;Colon Carcinoma;Colorectal Cancer;Complex;Computational algorithm;Computer Analysis;Consumption;Cytidine;Cytochrome c Reductase;Cytosine;Data;Data Set;Dependence;Development;dimer;DNA;DNA Binding Domain;DNA Sequence Alteration;dosage;driver mutation;Engineering;Enzymes;experience;experimental study;Generations;Genes;Genetic;Genetic Engineering;Genetic Induction;genetic manipulation;Genetic Transcription;Genomics;Germ Lines;Germ-Line Mutation;Glucose;heteroplasmy;Impairment;Induced Mutation;innovation;interdisciplinary approach;Investigation;Isotopes;Malignant neoplasm of thyroid;Malignant Neoplasms;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Methods;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;Modeling;molecular phenotype;Molecular Profiling;mutant;Mutation;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Outcome;Oxidative Phosphorylation;Oxygen Consumption;Pathogenicity;Pathway interactions;Pattern;Phenotype;Physiological;Point Mutation;pressure;Proliferating;Proteins;Recurrence;Renal Carcinoma;Residual state;RNA;Sampling;single cell sequencing;single-cell RNA sequencing;Technology;Testing;Therapeutic;Time;Tissues;tool;transcriptomics;tumor;tumor metabolism;Variant

PROJECT_TITLE: Defining the function of Complex I truncating mutations in cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: GRUENEWALD, PAUL J (contact)

PROJECT_TERMS: Achievement;Address;Advocate;Affect;Agreement;alcohol availability;Alcohol consumption;alcohol content;alcohol related problem;Alcohols;Area;base;Beer;Beverages;Censuses;Characteristics;Code;Communities;consumer demand;cost;Crime;Crowding;Data;Data Set;Databases;Differential Equation;Economic Conditions;Economics;experience;Failure;Geographic Information Systems;Geographic Locations;Geography;Goals;Guidelines;Hour;Interpersonal Violence;Licensing;Link;Measurement;Measures;Mediating;Mediator;Modeling;Morbidity - disease rate;mortality;Neighborhoods;Pharmaceutical Preparations;population health;Prevention approach;Price;Process Assessment;Public Health;Regulation;Research;Research Institute;Research Methodology;Research Personnel;Resolution;Restaurants;Risk;rural area;Sales;skills;social;socioeconomics;suburb;System;Taxes;Testing;Theoretical Studies;theories;Time;Universities;Visit;Western Australia;Wine;Work

PROJECT_TITLE: Community Alcohol Sales and Related Problems: Filling the Critical Research Gap


PHR: NARRATIVE Continued progress in oncology relies on training the next generation of physicians for careers in research. The Washington University StAAR Program in Cross-Disciplinary Oncology Training will IDENTIFY, RECRUIT, TRAIN, RETAIN, and ADVANCE outstanding physicians in oncology-focused graduate medical education (GME) training (i.e. “residency”) for careers as clinician-investigators.

PI_NAMEs: OLSON, JOHN A. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: academic program;Acceleration;Advisory Committees;anti-cancer research;Basic Science;bench to bedside;Biomedical Research;Cancer Biology;career;Career Choice;career development;Clinical;Clinical Research;Collaborations;Communities;Companions;Compensation;Competence;Critiques;Dedications;Dermatology;design;Development;Discipline;Doctor of Philosophy;Early Diagnosis;early experience;Education;Educational Curriculum;Educational workshop;Elements;Eligibility Determination;Ensure;Environment;Epidemiology;Evaluation;experience;Face;Fellowship;follow-up;Fostering;Funding;Generations;Genetic;Genomics;global health;Goals;graduate medical education;Grant;Health Professional;Health Status;Immunobiology;Immunotherapy;Individual;innovation;Institution;interest;Internal Medicine;Investigation;K-Series Research Career Programs;Life Style;Longterm Follow-up;Malignant Neoplasms;Medical Oncology;Medicine;Mentors;Modernization;National Cancer Institute;neurosurgery;next generation;novel;Oncology;Operative Surgical Procedures;Pathology;Physicians;Prevention;Principal Investigator;Program Development;programs;Public Health;Radiation Oncology;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;Science;Scientist;Secure;skills;Structure;Surgical Oncology;Time;Training;Training and Education;Training Programs;Translational Research;United States;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: StARR Program in Cross-Disciplinary Oncology Clinician-Scientist Training


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PI_NAMEs: FLAHERTY, LAWRENCE E (contact)

PROJECT_TERMS: anti-cancer research;Area;authority;Bioinformatics;Biometry;Cancer Center;Cancer Center Support Grant;Cancer health equity;Cancer Patient;Clinical;Clinical Research;Clinical Research Protocols;Clinical Trials;Committee Members;community engagement;Complement;Data;Discipline;Ensure;human subject protection;Institutional Review Boards;interest;Malignant Neoplasms;medical specialties;metabolomics;Mission;Monitor;multidisciplinary;Pharmacology;Process;Protocols documentation;Research;Research Design;Research Personnel;Research Support;Resources;Role;Safety;Support System;System;Time

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Biomedical Imaging;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: MINNEAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Current functional neuroimaging studies target either the brain or the spinal cord, but usually not both at the same time because simultaneous acquisitions from brain and spinal cord are challenged by several obstacles posed by conventional MRI modalities. In this project we will exploit a novel MRI pulse sequence entitled Multi- Band SWeep Imaging with Fourier Transformation (MB-SWIFT) that overcomes such challenges and will allow for the first time simultaneous fMRI of brain and spinal cord. The proposed study will prove that MB-SWIFT is a transformative approach for conducting unprecedented investigations of the central nervous system, crucial for advancing knowledge in several areas of research including spinal cord injury, neurodegenerative diseases, pain and aging.

PI_NAMEs: GROHN, OLLI ;MANGIA, SILVIA ;MICHAELI, SHALOM  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: 3-Dimensional;Aging;Area;Biomedical Research;Brain;Brain imaging;Breathing;Cardiac;Central Nervous System;Cervical;clinical application;Collaborations;Data;Dedications;design;Development;Distant;Electrophysiology (science);Evaluation;Excision;Finland;Fourier Transform;Functional Imaging;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Human;Image;imaging modality;Individual;Institution;Investigation;Knowledge;Location;Lumbar spinal cord structure;magnetic field;Magnetic Resonance Imaging;Measures;member;Methods;millisecond;Minnesota;Modality;Morphologic artifacts;Motion;Nervous System Physiology;Neurodegenerative Disorders;neuroimaging;Neurons;Noise;novel;novel strategies;Outcome;Pain;Physiologic pulse;Physiological;Positioning Attribute;pre-clinical research;Predisposition;prevent;Procedures;Protocols documentation;Publications;Radial;Rattus;Reproducibility;Research;Research Design;resilience;Resolution;Rest;RF coil;Sampling;Scheme;Site;Slice;Spinal Cord;Spinal cord injury;Surrogate Markers;Techniques;Testing;Time;tool;translation to humans;Universities;virtual

PROJECT_TITLE: MB-SWIFT as a novel approach for simultaneous functional imaging of the brain and spinal cord


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

PHR: PUBLIC HEALTH NARRATIVE Anhedonia is a transdiagnostic symptom of multiple psychiatric disorders, including depression, schizophrenia and post-traumatic stress disorder, which are linked with increasingly high levels of economic burden related to substantial health care costs and unemployment. Anhedonia is independently associated with substantially increased risk of suicide, treatment resistance and reduced quality of life, yet its biological basis remains elusive. We will use computational models of behavior and cutting-edge neuroimaging techniques in combination with artificial intelligence approaches to biologically define anhedonia, with the ultimate goal of improving clinical practice for anhedonia through biologically informed clinical decision-making.

PI_NAMEs: THAYER, JULIAN F.;YASSA, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Adult;Age Years;Algorithms;Anhedonia;Artificial Intelligence;artificial intelligence algorithm;Behavior;Behavioral;Biological;Biological Markers;biomarker validation;Brain;brain based;candidate marker;Clinical;clinical decision-making;clinical practice;cognitive system;cognitive task;Communities;Computational Technique;Computer Models;Coupling;Data;Decision Making;Diagnosis;Diagnostic;Diffusion;Dimensions;Disease;Economic Burden;Episodic memory;experience;Female;flexibility;Functional disorder;Functional Magnetic Resonance Imaging;Goals;gray matter;Health Care Costs;heart rate variability;Hippocampus;imaging modality;Impairment;improved;Individual;innovation;Intervention;Knowledge;Learning;Libraries;Link;Magnetic Resonance Imaging;Major Depressive Disorder;Maps;mathematical model;Measurement;Measures;Mediating;Memory;memory process;Mental Depression;Mental disorders;multimodality;National Institute of Mental Health;neurobiological mechanism;Neurobiology;neuroimaging;neuromechanism;Neurosciences;novel;Outcome;Patient Selection;Patient Self-Report;Pattern;pharmacologic;pleasure;Positive Valence;Post-Traumatic Stress Disorders;predictive marker;preservation;Prevention;Probability;Process;Psychiatry;Psychological reinforcement;Psychophysiology;Public Health;Quality of life;rapid growth;recruit;Regulation;Research;Research Domain Criteria;Resistance;Resolution;Rest;reward circuitry;reward processing;Rewards;Risk;Sampling;Schizophrenia;Severities;Signal Transduction;Stimulus;Structure;suicidal risk;Symptoms;Techniques;Testing;therapy resistant;Time;tool;treatment response;Unemployment;Ventral Striatum;white matter

PROJECT_TITLE: Testing a Memory-Based Hypothesis for Anhedonia

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE The Society for Reproductive Investigation (SRI) meeting serves to bring together scientists and clinicians, established and early career investigators from around the world, to report and discuss their findings in an atmosphere conducive to productive scientific exchange. This application seeks funding to cover travel costs for seven trainees and early stage investigators to attend the annual SRI meeting and for an established investigator to attend the meeting where he/she will present an invited Distinguished Presidential plenary lecture.

PI_NAMEs: KHABELE, DINEO  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Area;Atmosphere;Australia;Award;Basic Science;Biochemistry;British Columbia;Canada;career;career development;Clinical;Clinical Sciences;Collaborations;Communicable Diseases;cost;Dedications;Development;Developmental Biology;Discipline;Discipline of obstetrics;Doctor of Philosophy;Educational workshop;Ensure;Environment;Epidemiology;equity, diversity, and inclusion;Event;Exposure to;Fertilization;Fostering;Foundations;Funding;Future Generations;Genetic;Goals;Government;Grant;Gynecologic Oncology;Gynecology;health disparity;Health Sciences;Healthcare;Hearing;Height;Immunology;Individual;International;Investigation;lecturer;lectures;Medicine;meetings;member;Mentors;Minority;Mission;next generation;Oral;Perinatology;Pharmacology;posters;Privatization;Productivity;Professional Organizations;programs;Reporting;Reproduction;reproductive;Reproductive Biology;Reproductive Endocrinology;Reproductive Immunology;Reproductive Medicine;Reproductive Physiology;Reproductive Sciences;Research;research and development;Research Personnel;Schedule;Science;Scientist;Societies;stem cell biology;Students;Study Section;symposium;Techniques;Technology;Training;Translational Research;Travel;Underrepresented Minority;United States National Institutes of Health;Woman;Women's Health;Work

PROJECT_TITLE: SRI Meeting: Training and Development in the Reproductive Sciences

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD(R)-R]