ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Pain Research;Primary Health Care

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative This research seeks to develop and test an integrated, multi-level, and interdisciplinary program in two schools of Dentistry that will promote a research “culture” among dental students, residents, clinical faculty, and throughout their oral health educational programs. Partnering between a research-intensive college of Dentistry (i.e., University of Florida) and a newer dental school (i.e., East Carolina University that has a growing research focus, there will be training in clinical research skills, team-based science, mentoring, and interdisciplinary collaboration, in the context of two clinical research studies with dental patients, one on diabetes detection and the other acute/chronic pain. This approach has the potential for dissemination to other schools of Dentistry and various health science training programs, with a positive impact on public health through a more research-informed and evidence-based workforce.

PI_NAMEs: MCNEIL, DANIEL W (contact);PAQUETTE, DAVID WAYNE

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Acute;Acute Pain;Address;Adult;Affect;analytical method;Area;Artificial Intelligence;career;Chronic;chronic pain;Classification;Clinic;Clinical;clinical practice;Clinical Research;Clinical Sciences;cohort;Collaborations;college;Communities;Competence;computerized data processing;Corporate Practices;Data;data collection site;Databases;Dental;Dental Care;Dental Education;Dental Faculty;Dental General Practice;Dental Schools;Dental Students;Dentistry;Dentists;design;Detection;Development;Diabetes Mellitus;Discipline;doctoral student;Education;Educational Curriculum;Educational Models;Ensure;ethnic diversity;Evaluation Studies;evidence base;Evolution;experience;Faculty;Florida;follow-up;Fostering;Funding;Future;Health;Health education;Health Sciences;Healthcare;improved;Institution;inter-institutional;interdisciplinary collaboration;Interdisciplinary Study;Intervention;Investigation;Leadership;Medicine;meetings;Mentors;Mentorship;Modeling;multidisciplinary;National Institute of Dental and Craniofacial Research;Non-Insulin-Dependent Diabetes Mellitus;Nursing Faculty;Oral;Oral health;Outcome;Pain;Pain Research;Patient-Focused Outcomes;Patients;peer coaching;Population;Postdoctoral Fellow;Practice based research;practice-based research network;pre-doctoral;Prediabetes syndrome;Process;programs;Public Health;racial diversity;Research;Research Activity;Research Project Grants;research study;Research Training;Resources;Role;Schedule;School Dentistry;Schools;Science;Scientist;screening;Site;skill acquisition;skills;skills training;Solo Practices;student mentoring;student training;success;Testing;Time;Training;Training Programs;Translating;Translational Research;Universities;University resources;Work

PROJECT_TITLE: Development of Opportunities for Research (DOOR) in Dental Schools: Future Academic Interdisciplinary Workforce and Collaborators for the National Dental Practice-Based Research Network (PBRN)


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: IRVINE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed study will deliver replicated findings of functional and structural connectivity abnormalities in schizotypy and schizophrenia based on large-scale, global, collaborative meta-analyses. It will identify shared brain connectivity abnormalities, associated with overlapping symptoms, and unique brain connectivity abnormalities, associated with non-overlapping functioning profiles between schizotypy and schizophrenia which lie at the extremes of the schizophrenia spectrum continuum. Finally, the study will generate label-noise-reduced, machine-learning based models that generate schizotypy protective and schizophrenia liability scores that may serve as biomarkers for functioning, and that may be predictive of functional outcome in schizophrenia and possibly individuals at clinical high risk for psychosis.

PI_NAMEs: MODINOS, GEMMA ;TURNER, JESS ;VAN ERP, THEODORUS G.M. (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Address;Adolescence;Adult;adverse outcome;Antipsychotic Agents;Autopsy;Biological Markers;Biology;Brain;brain abnormalities;brain circuitry;Brain Diseases;Brain imaging;Brain region;Characteristics;Chronic;Clinical;Clinical Data;clinical high risk for psychosis;cohort;Complex;Confounding Factors (Epidemiology);cost;Data;data integration;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;Early identification;Early treatment;functional improvement;Functional Magnetic Resonance Imaging;functional outcomes;Future;General Population;Genetic;Goals;gray matter;Health;Image;Image Analysis;improved;Individual;Inherited;innovation;Interneurons;Joints;Label;machine learning method;machine learning model;Magnetic Resonance Imaging;Measures;Mental disorders;Meta-Analysis;Modeling;multimodal neuroimaging;multimodality;neural;Neurobiology;neuroimaging;neuroimaging marker;Neuropil;Noise;novel;Outcome;Pathway interactions;Patient Self-Report;Patients;Pattern;Personality Traits;Pharmaceutical Preparations;Pharmacotherapy;Populations at Risk;predict clinical outcome;Prefrontal Cortex;Prevention;Preventive treatment;Procedures;Psychoses;psychotic;psychotic symptoms;quality assurance;Research;resilience;Rest;Risk;risk prediction;Role;Schizophrenia;schizophrenia spectrum disorder;Severities;Shapes;side effect;Standardization;Statistical Data Interpretation;Structure;Symptoms;Synapses;Testing;Thick;Thinness;trait;Work;working group

PROJECT_TITLE: Neuroimaging Dimensions at the Extremes of the Schizophrenia Spectrum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-B(90)M]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PI_NAMEs: BERENS, MICHAEL E. (contact)

PROJECT_TERMS: Bioinformatics;Biological Products;Biometry;Bortezomib;Cancer Therapy Evaluation Program;candidate identification;Caring;Cells;Clinical Trials;Combined Modality Therapy;Correlative Study;Coupled;Data;data sharing;design;Development;DNA;Dose;drug development;drug discovery;Drug Targeting;Eligibility Determination;Enrollment;Etoposide;exome;Future;Genes;genomic signature;Glioblastoma;Glioma;Goals;Growth;Heterogeneity;Homeostasis;improved;in vitro Model;in vivo;inhibitor;Link;Malignant Glioma;Malignant Neoplasms;Maximum Tolerated Dose;Microdialysis;Modeling;Molecular;Molecular Profiling;molecular subtypes;multicatalytic endopeptidase complex;Mutate;Outcome;Participant;participant enrollment;Pathway interactions;patient derived xenograft model;Patient Recruitments;Patient-Focused Outcomes;Patients;Penetration;Performance;Pharmaceutical Preparations;Phase;phase 1 study;Phase I Clinical Trials;Phenotype;Play;Pre-Clinical Model;precision medicine;predicting response;Proteasome Inhibitor;protein degradation;Proteins;PTEN gene;Recommendation;Recurrence;Research Project Grants;Resected;response;Role;Safety;Sampling;Signal Transduction;small molecule;small molecule inhibitor;Specificity;Stream;synergism;System;targeted agent;Teniposide;Testing;therapeutic target;timeline;TOP2A gene;Toxic effect;transcriptome sequencing;tumor;Ubiquitin;Up-Regulation;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Signature-guided treatment of GBM with neddylation inhibitor pevonedistat


ADMINISTERING_IC: EB

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Prevention;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: According to Instructions for the Submission of Mulit-Component Applications in PAR-22-203, for Administrative, Technology, Clinical and Dissemination Cores: “Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.”

PI_NAMEs: RICHARDS-KORTUM, REBECCA R. (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;algorithm development;Artificial Intelligence;Biological Assay;Biomedical Engineering;Brazil;cancer care;cancer health disparity;Caring;Clinical;clinically relevant;Collaborations;Collection;commercial prototype;commercialization;Computers;Consensus;COVID-19 test;COVID-19 testing;Decentralization;design;Development;Diagnostic;diagnostic technologies;Disease;Early Diagnosis;Engineering;Equity;Evaluation;experience;fabrication;Funding;Generations;global health;Goals;Growth;Health Technology;Health trends;Healthcare;home test;Image;Image Analysis;Imaging Device;Imaging technology;improved;Infrastructure;innovation;Instruction;Intervention;laboratory equipment;Link;low and middle-income countries;Machine Learning;manufacturability;manufacture;Marketing;Mediation;Medical center;Mentorship;Mission;mobile computing;Molecular;molecular diagnostics;Monitor;pandemic disease;Performance;point of care;Point of Care Technology;point of care testing;point-of-care diagnostics;prototype;Publishing;RADx;recruit;research clinical testing;Research Personnel;Resource-limited setting;Resources;response;Rice;rural setting;screening;Screening for cancer;self testing;sensor;Services;Shapes;Specific qualifier value;success;System;Technology;technology platform;Test Result;Testing;Texas;Translating;Translations;underserved community;Underserved Population;Universities;usability;Validation;Work

PROJECT_TITLE: Technology Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Understanding the earliest pathologic changes in Dementia with Lewy bodies (DLB) is critical to developing neuroprotective therapies for this devastating dementia. Defects in the energy systems of brain cells are thought to be critically involved, but this has been difficult to study in people. This study utilizes a combination of brain imaging techniques and other measures, in people who are at risk for or have developed DLB, in order to determine how and when the energy system fails and to help guide development of targeted protective therapies.

PI_NAMEs: AIZENSTEIN, HOWARD J;BERMAN, SARAH B (contact);VILLEMAGNE, VICTOR LUIS;YANG, SHAOLIN

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Address;Adenosine Triphosphate;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;amyloid pathology;Animal Model;Autopsy;Behavioral;Bioenergetics;Biological;Blood Platelets;Brain;brain cell;Brain imaging;Brain region;Cell model;Clinical;cognitive function;cognitive performance;cohort;Complex;Data;Defect;Dementia;Dementia with Lewy Bodies;Development;Disease;Energy Metabolism;Evaluation;Event;Failure;fluorodeoxyglucose positron emission tomography;Functional disorder;Glycolysis;Human;Image;imaging modality;Imaging Techniques;Impaired cognition;in vivo;inorganic phosphate;Link;longitudinal design;Magnetic Resonance Spectroscopy;Measurement;Measures;Metabolic dysfunction;Metabolic Pathway;Metabolism;Methodology;Mitochondria;mitochondrial dysfunction;Motor;multimodal neuroimaging;Neurocognitive;neurocognitive test;neurodegenerative dementia;neuroimaging;Neuropathogenesis;neuroprotection;Noise;Outcome;Participant;Pathogenesis;Pathologic;Pathway interactions;Patients;Pattern;Peripheral;Persons;Phosphocreatine;Phosphorus;Positron-Emission Tomography;Process;Publishing;radioligand;Regulation;Reporting;Resolution;Respiration;Respiration Disorders;respiratory;Respiratory Chain;Risk;Role;Signal Transduction;Skin;Sleep Disorders;Smell Perception;synucleinopathy;System;targeted treatment;Testing;therapeutic target;Time

PROJECT_TITLE: Brain mitochondrial PET imaging and 31P-MR spectroscopy to dissect the role of mitochondrial dysfunction in bioenergetic dysregulation in Dementia with Lewy Bodies pathogenesis

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Health Services;Pain Research;Prevention;Primary Health Care

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative This proposal aims to advance the knowledge and skills of next-generation dental clinicians to conduct practice-based research (PBR), acquire critical thinking skills, and facilitate interprofessional communication and care to address dental patients’ conditions such as Sjögren’s Disease (SD) that require multidisciplinary expertise for timely diagnosis and management. The PBR study will develop a salivary hypofunction index in combination with salivary biomarkers to detect patients susceptible to SD, thus improving shared decision- making and management of patients at risk for SD.

PI_NAMEs: BRUZZANITI, ANGELA ;SRINIVASAN, MYTHILY ;THYVALIKAKATH, THANKAM P (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Address;Affect;Arthralgia;Autoantibodies;Award;Awareness;Basic Science;Behavior;Biological Markers;biomarker identification;biomarker selection;biomarker validation;Biopsy;care coordination;career development;Career Mobility;Caring;Characteristics;Clinical;clinical practice;Clinical Research;Clinical Research Protocols;Clinical Sciences;Collaborations;college;Communication;Community Practice;Competence;Consent;Consultations;Critical Thinking;Dental;Dental Clinics;Dental General Practice;Dental Research;Dental Schools;Dental Students;design;Diagnosis;Disease;Disease Management;Disease Progression;Disease susceptibility;disorder risk;Dryness;early detection biomarkers;Early Diagnosis;education research;Educational Curriculum;Effectiveness;Electronic Health Record;evidence base;experience;Faculty;Fatigue;Fellowship;Fibromyalgia;follow-up;Foundations;Funding Opportunities;Goals;Health;Health Personnel;Health Professional;Healthcare;Immunoglobulin G;implementation protocol;improved;indexing;Indiana;Individual;Informatics;inter-institutional;Knowledge;Lead;Longitudinal Studies;Managed Care;Measurable;Measures;Medical;Medical Research;medical schools;Medicine;Mentors;Mentorship;Minor salivary gland structure;multidisciplinary;National Institute of Dental and Craniofacial Research;next generation;Nursing Faculty;Oral;Oral Characters;Oral Examination;Oral health;Outcome;Outcome Measure;Participant;patient oriented research;Patient-Focused Outcomes;Patients;peer;Persons;Pharmacists;Pharmacy facility;Play;Postdoctoral Fellow;Practice based research;practice setting;practice-based research network;pre-doctoral;predictive marker;Predisposition;programs;protein biomarkers;randomized, controlled study;Readiness;recruit;Research;Research Activity;Research Personnel;Research Project Grants;research study;Research Training;rheumatologist;Role;Saliva;saliva diagnostic;Salivary;Schedule;School Dentistry;Serum;Shapes;shared decision making;Sjogren's Syndrome;skill acquisition;skills;Standardization;Students;Teacher Professional Development;telehealth;Testing;Tissues;Training;Training and Education;Translating;Translational Research;treatment planning;Universities;virtual health;willingness;Woman;Writing;Xerostomia

PROJECT_TITLE: Establishing Readiness of Dental Professionals in Practice-Based Research and Inter-Professional Care


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Congenital Structural Anomalies;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The proposed work examines the role of PIDD1 in brain development and is motivated by genetic findings in patients with lissencephaly, a devastating disorder characterized by simplified or absent convolutions in the anterior part of the brain. The work aims to understand the function of PIDD1 in mammalian brain development and to apply a novel approach to the analysis of existing whole exome sequencing datasets from additional patients with smooth brain, to discover other genes and gene networks that are involved in this condition. Successful completion of the work will provide insights into the biology and function of PIDD1, expand our understanding of the development of the normal brain and the genetic causes of smooth brain, and inform future studies aimed at the identification of possible interventions for this disorder.

PI_NAMEs: BILGUVAR, KAYA ;LOUVI, ANGELIKI  (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Anterior;Apoptosis;Biology;Brain;Brain Diseases;brain malformation;Candidate Disease Gene;candidate identification;CASP2 gene;causal variant;Cell Cycle Arrest;Cell Line;Cell Physiology;cell type;Centrosome;Cerebral cortex;Cerebrum;cohort;consanguineous family;Cortical Malformation;Critical Thinking;Data;Data Set;Development;Developmental Delay Disorders;developmental disease;Disease;disease-causing mutation;DNA Damage;DNA sequencing;Embryo;Etiology;exome sequencing;Family;fetal;Future;gene discovery;gene network;Genes;Genetic;Genetic Complementation Test;genetic disorder diagnosis;Genetic Heterogeneity;genome editing;Genomics;Genotype;Health;Heterogeneity;Human;human stem cells;Impairment;In Vitro;in vivo;indexing;induced pluripotent stem cell;Induction of Apoptosis;insight;Intellectual functioning disability;Intervention;Investigation;keratinocyte;kindred;Knock-in;lissencephaly;malformation;Mediating;member;Mendelian disorder;Methods;migration;Modeling;Molecular;mouse model;Multiprotein Complexes;Mus;mutant;Mutant Strains Mice;Mutation;neocortical;nerve stem cell;Network-based;neural;neurodevelopment;neurogenesis;neurogenetics;Neuroglia;Neuronal Differentiation;Neurons;next generation;next generation sequencing;novel;novel strategies;Organelles;Organoids;pachygyria;Pathogenicity;Pathology;Pathway Analysis;Pathway interactions;patient - derived stem cells;Patients;Phenotype;Pilot Projects;Polynomial Models;Process;protein complex;Reporting;response;RNA Splicing;Role;Sampling;segregation;Seizures;single-cell RNA sequencing;Site;stem cell model;stem cell proliferation;System;Thinness;Validation;Variant;virulence gene;Work

PROJECT_TITLE: A Gene-Network Discovery Approach to Structural Brain Disorders

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;Africa;Animals;Benchmarking;Biometry;Brazil;Budgets;cancer care;cancer health disparity;cancer prevention;Caring;Cessation of life;Characteristics;China;Clinic;Clinical;Clinical Trials;Collaborations;college;commercialization;Communities;Community Health Aides;Comparative Biology;cost effective;cost effectiveness;Country;design;Development;Devices;Diagnosis;Disease;Early Diagnosis;Effectiveness;Engineering;Ensure;Environmental Exposure;Equity;Europe;Evaluation;experience;Face;Family;Feedback;Genetic;Goals;Health system;Healthcare;Home;implementation evaluation;implementation facilitation;implementation facilitators;implementation outcomes;improved;Income;India;Infrastructure;innovation;Instruction;International;Laboratories;Latin America;Lesion;low and middle-income countries;Malignant Neoplasms;Medical center;Medicine;models and simulation;Morbidity - disease rate;mortality;Mozambique;multidisciplinary;Pathologist;Pathology;Patients;Performance;Point of Care Technology;point of care testing;Population Heterogeneity;premalignant;Prevention;Prevention strategy;prototype;Provider;Race;recruit;Research;research clinical testing;Research Design;Research Personnel;Resource-limited setting;Resources;scale up;screening;Screening for cancer;Services;simulation;socioeconomics;System;Technology;technology development;technology validation;Texas;tool;Translating;Translations;underserved area;usability;Validation;Veterinarians;Visit;Work

PROJECT_TITLE: Clinical Core


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Despite the evidence for reduced morbidity and mortality for people with HIV (PWH) who receive tuberculosis preventive therapy (TPT), and guidelines recommending TPT for PWH and other persons at high risk for TB including contacts, there remains a substantial gap between people recommended to receive and people who actually receive and complete a course of TPT. With the recent availability and evidence for newer, shorter TPT regimens (e.g. 3HP, 12 weekly doses of isoniazid and rifapentine), and successful transformation of HIV care delivery models (in part forced by the COVID-19 pandemic), it is increasingly urgent to adapt and investigate new patient-friendly, differentiated service delivery models for TPT in order to inform programmatic guidance that results in greater uptake, adherence, and completion of TPT. We will conduct a randomized controlled trial of community-based vs. clinic-based TPT delivery among people participating in a community-based TB screening program in South Africa, examine barriers and facilitators of TPT completion with qualitative research, and explore the feasibility of task-shifted TPT delivery engaging pharmacy staff in South African public sector clinics.

PI_NAMEs: SHAPIRO, ADRIENNE E (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: acceptability and feasibility;Adherence;Adopted;Adult;Adverse effects;Caring;Cessation of life;Client;Clinic;Clinical;Communicable Diseases;Communities;community setting;Community Trial;cost;COVID-19 pandemic;Data;Decentralization;Dose;Drug resistance in tuberculosis;Effectiveness;Eligibility Determination;Exercise;experience;Focus Groups;Foundations;Friends;gaps in access;Guidelines;health care delivery;high risk;HIV;implementation science;implementation strategy;improved;Incidence;Individual;innovation;International;intervention refinement;Interview;isoniazid;Laboratories;Maps;Measures;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Nurses;Participant;participant interview;Pathway interactions;patient oriented;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;pill;Population;pre-exposure prophylaxis;prevent;preventable death;Prevention;Preventive;Preventive therapy;Preventive treatment;programs;Public Sector;Qualitative Research;Randomized;Randomized, Controlled Trials;Recommendation;Regimen;Reporting;Research;response;rifapentine;Risk;Safety;scale up;Schedule;screening;screening program;Serum;service delivery;Service delivery model;Services;South Africa;South African;standard of care;supply chain;Surveys;System;Therapeutic Studies;therapy adherence;therapy design;Time;Toxic effect;Translating;Travel;Treatment Protocols;Triage;trial comparing;Tuberculosis;Tuberculosis diagnosis;uptake;Visit;willingness;World Health Organization

PROJECT_TITLE: New pathways to prevention from community TB screening in South Africa

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;Brazil;cancer care;cancer health disparity;Caring;Case Study;Cervical Cancer Screening;Clinical;Clinical effectiveness;Collaborations;commercialization;Communication;Communities;Community Healthcare;comparative;Consensus;cost-effectiveness evaluation;Development;Device Designs;Device or Instrument Development;Diagnosis;diagnostic technologies;Early Diagnosis;Educational workshop;effective intervention;effectiveness testing;efficacy testing;Engineering;Ensure;Equity;Evaluation;evaluation/testing;health care delivery;Health Care Sector;health care settings;Human Papillomavirus;implementation facilitators;implementation science;improved;innovation;Instruction;Joints;Knowledge;Marketing;medically underserved;Mozambique;Needs Assessment;novel;novel diagnostics;Patients;Peer Review;Performance;point of care;Point of Care Technology;point-of-care diagnostics;Process;Professional Organizations;prototype;Public Health;Public Health Education;Publications;Publishing;Readiness;Research Personnel;Resource-limited setting;routine care;scale up;Scientist;Screening for cancer;Site;Site Visit;success;symposium;System;Technology;Training;Training and Education;Training Programs;Translations;uptake;Visit;webinar;Work;World Health

PROJECT_TITLE: Dissemination Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative This proposal will examine the impact of Maryland’s Global Budget Revenue (GBR) program on spending, utilization, and quality of care for individuals with cancer in Maryland and similar patients in control states. As policy makers consider expanding the GBR program, this proposal has important public health implications because it evaluates a population that disproportionately drives Medicare spending, and it seeks to determine if this program leads to inequities in care for historically marginalized populations.

PI_NAMEs: OFFODILE, ANAEZE C (contact)

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: access disparities;access restrictions;Accident and Emergency department;Acute;acute care;Address;Adopted;Adult;Adverse effects;Affect;Area;beneficiary;Budgets;cancer care;Cancer Patient;cancer therapy;care delivery;care episode;care outcomes;Caring;chemotherapy;Clinical;Consultations;cost;Cost Control;deprivation;design;dual eligible;Emergency department visit;end of life;Ethnic Origin;Evaluation;Fee-for-Service Plans;financial incentive;Funding;Future;Growth;Health Expenditures;Healthcare;hospice utilization;hospital care;hospital readmission;hospital services;Hospitalization;Hospitals;Immunotherapy;improved;Incentives;Individual;Inequity;Infusion procedures;inpatient service;Institute of Medicine (U.S.);Insurance;interest;Light;Malignant Neoplasms;marginalization;marginalized population;Maryland;Medicaid;Medical;Medicare;Modeling;mortality;Oncologist;Oncology;Oral;Outcome;outpatient programs;Outpatients;Patient Care;patient oriented;Patient Selection;Patients;payment;Performance;Pharmaceutical Preparations;Pharmacotherapy;Physicians;Physicians' Offices;Policy Maker;Population;prevent;Price;programs;prospective;Provider;Public Health;Quality of Care;Quasi-experiment;Race;racial minority;Reporting;Research;response;Risk;Risk Adjustment;risk mitigation;Savings;Services;Site;social;socioeconomics;Structure;System;targeted treatment;Testing;Time;Trust;United States;United States Centers for Medicare and Medicaid Services;Update;Variant;Visit;waiver

PROJECT_TITLE: Examining the effects of Global Budget Revenue Program on the Costs and Quality of Care Provided to Cancer Patients Undergoing Chemotherapy

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Complementary and Integrative Health;Data Science;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative The recent public successes of deep learning have reinvigorated computational thinking around healthcare and biology. This work develops rigorous methods and tools ensuring the efficient application of machine learning principles to computational biology. This will save resources and make these tools more reliable when they are ultimately deployed for diagnostic, research, or clinical purposes.

PI_NAMEs: GIBSON, TRAVIS ELI (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Algorithms;Alternative Therapies;Area;Bacteria;Biological;Biological Models;Biological Sciences;Biology;Certification;Clinic;Clinical;Communities;Complex;Computational Biology;computational reasoning;Computer software;computerized tools;Data;Data Set;deep learning;deep learning model;deep neural network;design;Development;Diagnostic;digital health;Disparate;dynamic system;Engineering;Ensure;Equus caballus;experimental study;flexibility;Germ-Free;Grant;health record;Healthcare;Hospitals;In Vitro;in vivo;in vivo Model;Machine Learning;machine learning model;mathematical learning;Measurement;Measures;member;Methods;microbial community;microbiota;Modeling;Mus;Organism;Pharmaceutical Preparations;Process;Property;Reproducibility;Research;resident commensals;Resources;Scheme;Series;success;System;Techniques;Time;tool;Training;Uncertainty;Work

PROJECT_TITLE: Machine Learning and Control Principles for Computational Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_NAME: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO

PHR: Project Narrative Results from the 2020 national survey on alcohol use and health show that about 17 million Americans met the diagnostic criteria for moderate to severe alcohol use disorder (AUD), and relapse to alcohol seeking has become a public health concern. Psychopathology of the medial prefrontal cortex (mPFC) has been implicated in enhanced propensity for relapse. In this proposal, using a well-established rodent model of moderate to severe AUD and enhanced propensity for relapse, we will begin to identify the role of endothelial cell specific junction protein cadherin-5 in the mPFC in relapse to ethanol seeking, and offer a mechanistic approach by evaluating the associated endothelial transcriptome, inflammatory and neuronal alterations in the mPFC.

PI_NAMEs: MANDYAM, CHITRA D (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Abstinence;Acute;Adherens Junction;Adult;Adult women;Alcohol consumption;Alcohol dependence;alcohol seeking behavior;alcohol use disorder;Alcoholism;American;angiogenesis;Angiogenesis Inhibitors;Anti-Inflammatory Agents;Biological Assay;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier disruption;Brain;Brain region;cadherin 5;Cadherins;CD31 Antigens;Cell Separation;Cells;chemokine;Chronic;Clinical Research;Collaborations;Cues;cytokine;Data;diagnostic criteria;drinking;drinking behavior;Electrophysiology (science);Endothelial Cells;Endothelium;Ethanol;Ethanol dependence;Female;Foundations;Functional disorder;functional plasticity;Funding;Future;Gene Expression;gliogenesis;Glutamates;Health;hippocampal pyramidal neuron;Immune response;Inflammatory;Inflammatory Response;Infusion procedures;Inhalation;male;Medial;Modeling;Neuronal Plasticity;Neurons;novel marker;Patients;Peptides;pharmacologic;Prefrontal Cortex;prolonged abstinence;Proteins;Psychopathology;Public Health;Publishing;Rattus;Relapse;relapse prevention;Research Institute;Rodent Model;Role;Self Administration;sex;sexual dimorphism;stem;Surveys;Synaptic plasticity;Testing;Therapeutic Agents;therapy design;transcriptome;transcriptome sequencing;Translational Research;vapor;Withdrawal;women versus men;Work

PROJECT_TITLE: Medial Prefrontal Cortical Gliogenesis and Alcohol Dependence

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE UCSF’s Clinical and Translational Research Innovation in Dental Schools (ClinTrain-RIDeS) will provide a robust clinical research development program at the individual trainee level (predoctoral and postdoctoral) with the overall goal of preparing the future pipeline of dentist-scientists (NIDCR Strategic Priorities 4.1 and 4.2 Diverse Research Pipeline), at the school level to create a supportive environment enabling and encouraging practice-based clinical research activities that lead to new discoveries and innovations in advancing oral health and the quality of dental care, and at the community-level to expand the reach of UCSF’s vast research resources to a new dental school (California Northstate University College of Dental Medicine) and several community-based clinics (NIDCR Strategic Priority 5.4.2). The practice-based artificial intelligence (AI)-generated caries diagnosis and treatment planning study will partner with a dental AI industry leader (NIDCR Strategic Priority 5.3 cross-sector initiatives with industry partners) to improve patient care (NIDCR Strategic Priority 2.2.3) and establish a Learning Health System (NIDCR Strategic Priority 3.3).

PI_NAMEs: BERENS, LISA ;GANSKY, STUART A (contact);OBADAN-UDOH, ENIHOMO MARY

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Adherence;Adult;Alaska;Apical;Applications Grants;Area;Artificial Intelligence;artificial intelligence algorithm;base;Basic Science;California;Clinic;Clinical;clinical decision support;clinical practice;Clinical Practice Guideline;Clinical Research;Clinical Research Protocols;Clinical Sciences;clinically relevant;Collaborations;college;Communities;Community Dentistry;Consent;cost;Data;Data Analyses;Data Collection;Decision Making;Dental;Dental Care;Dental caries;Dental Education;Dental Faculty;Dental Research;Dental Schools;Dental Students;Dentistry;Dentists;design;Detection;Development;Diagnosis;Diagnostic;Discipline;doctoral student;Education;education research;Educational Curriculum;Environment;evidence base;Evidence based practice;Evidence based treatment;experience;externship;Faculty;faculty community;faculty research;Feasibility Studies;Fostering;Funding;Future;Goals;Health system;improved;In Situ;Incubated;Incubators;Individual;Industry;industry partner;Infrastructure;innovation;Institution;Lead;Learning;Medicine;member;Mentors;Mentorship;Methods;Mission;Modality;National Institute of Dental and Craniofacial Research;novel diagnostics;Nursing Faculty;Oral Examination;Oral health;Patient Care;Patients;peer coaching;Periodicals;Phase;Pilot Projects;population health;Postdoctoral Fellow;Practice based research;Practice Guidelines;pre-doctoral;Process;Professional Education;Prognosis;Program Development;programs;prospective;Prospective, cohort study;Protocols documentation;Recording of previous events;recruit;Research;Research Activity;Research Design;research faculty;Research Methodology;Research Personnel;Research Project Grants;research study;Research Training;Resources;Roentgen Rays;Scanning;School Dentistry;Schools;Scientist;Silicon;Site;skill acquisition;skills;Specialist;student mentoring;Students;support tools;supportive environment;Testing;Time;Training;Training Programs;Translational Research;treatment guidelines;treatment planning;United States National Institutes of Health;Universities;usability;Visit


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pain Research;Prevention;Primary Health Care

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative The Harvard School of Dental Medicine Collaborative Clinical Practice-based REsearch Program for DENTal Schools (H-CREDENT) will engage dental students and residents with research and clinical-based faculty in an integrated, experiential, multidisciplinary dental school practice-based clinical research program. Outcomes of the clinical investigation of disabling pain following dental procedures will allow risk stratification via artificial intelligence/machine learning using patient demographics, clinician management, patient psychosocial determinants, and salivary-based genomic measures. H-CREDENT will advance NIDCR’s national public health research mission in the training of next-generation oral healthcare workforce in the conduct of dental practice- based clinical research.

PI_NAMEs: GIANNOBILE, WILLIAM V (contact)

PROJECT_TERMS: Active Learning;Address;Aptitude;Artificial Intelligence;Basic Science;career;catalyst;Clinical;clinical care;clinical investigation;clinical practice;Clinical Research;Collaborations;college;Communities;community partners;craniofacial;Dedications;demographics;Dental;Dental Care;Dental Education;Dental Faculty;Dental General Practice;Dental Schools;Dental Students;Dentistry;Development;doctoral student;Enrollment;experience;Face;Faculty;follow-up;Fostering;Genetic;Genomics;Goals;Health Alliance;health care delivery;Health Personnel;Health Sciences;Healthcare;healthcare burden;high risk;Individual;innovation;Institution;inter-institutional;Investigation;Learning;longitudinal, prospective study;Machine Learning;machine learning method;Massachusetts;Measures;Medicine;member;Mentors;Mentorship;Mission;multidisciplinary;National Institute of Dental and Craniofacial Research;Neighborhood Health Center;New England;next generation;Oral;Oral health;Outcome;Pain;Pain management;pain-related disability;Participant;patient stratification;Patients;peer;Pharmacy facility;Population;Post-Procedural Pain;Postdoctoral Fellow;Postoperative Pain;Practice based research;practice-based research network;Predictive Factor;Private Practice;Problem Solving;Program Development;programs;prospective;Provider;psychosocial;public health research;recruit;Research;Research Design;research faculty;Research Methodology;Research Personnel;Risk;Risk Factors;risk stratification;Salivary;Scientific Inquiry;Site;skill acquisition;Stratification;Students;Training;Training Programs;Translational Research;Universities;Work


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Sleep Research;Social Determinants of Health;Substance Misuse;Sudden Infant Death Syndrome;Tobacco;Tobacco Smoke and Health

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Public Health Relevance Fetal alcohol spectrum disorder (FASD) is completely preventable, yet remains among the top 3 known causes of intellectual disability with an estimated prevalence of 2.4-4.8% in the US that accrues costs to society greater than $3 billion annually. Most children with FASD experience greater early life adversity compared to non-exposed children, yet little is known about how the perinatal, infant and early childhood environment interacts with the effects of prenatal alcohol exposure (PAE) on brain and cognitive development. Capitalizing on the large prospective cohort study of children in South Africa where rates of maternal alcohol consumption are high, and in which mothers reported on alcohol consumption during and throughout pregnancy, will allow us to address significant gaps in knowledge about the impact of PAE across the full range of maternal drinking patterns on later brain and cognitive development, as well as interactive effects with early life environment.

PI_NAMEs: SOWELL, ELIZABETH R (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: 12 year old;15 year old;3-Dimensional;Address;Adolescence;Age;Alcohol consumption;alcohol exposure;Alcohols;Amygdaloid structure;Animal Experimentation;Animal Model;Back;Behavior;binge drinking;Birth;Brain;Caregivers;Cerebellar vermis structure;Child;Childhood;Cognition;Cognitive;cognitive development;cognitive function;cognitive testing;cohort;Cohort Studies;Corpus Callosum;cost;Coupled;COVID-19 pandemic;Data;Data Set;Development;Discipline of obstetrics;drinking;drinking behavior;Dysmorphology;early childhood;Early Intervention;early life adversity;Economics;Enrollment;Environment;Environmental Risk Factor;environmental tobacco smoke exposure;Exhibits;experience;Exposure to;externalizing behavior;Face;Family;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;fetal tobacco exposure;First Pregnancy Trimester;Frequencies;Funding;girls;Hippocampus;Home;Human;Image;Impaired cognition;in utero;Income;Individual;Infant;Infrastructure;innovation;insight;Intellectual functioning disability;Investigation;Knowledge;Life;Life Experience;Light;Longitudinal Studies;low socioeconomic status;Maternal Age;maternal alcohol use;maternal risk;Measures;Mediating;Medical;Mental Health;Morphology;Mothers;Nature;neuroimaging;novel;nutrition;Outcome Measure;parity;Participant;Patient Recruitments;Pattern;Perinatal;perinatal period;Population;Positioning Attribute;postnatal;Poverty;Pregnancy;pregnant;prenatal;Prevalence;Problem behavior;Productivity;prospective;Prospective, cohort study;public health relevance;Publishing;Recording of previous events;recruit;Reporting;Research Design;research study;resilience;Resources;Risk;Risk Factors;Sampling;Selection Criteria;social;Societies;South Africa;South African;stillbirth;Stress;Structure;substance use;Sudden infant death syndrome;Thick;Time;Tobacco use;toxicant;white matter;Youth

PROJECT_TITLE: Brain and Cognitive Development in the PASS Cohort: The Impact of PrenatalAlcohol Exposure


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: MEMPHIS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MEMPHIS

ORG_STATE: TN

PHR: PROJECT NARRATIVE/PUBLIC HEALTH SIGNIFICANCE Alcohol misuse is the largest source of morbidity and mortality in emerging adults (age 18-29) in the United States and the ongoing COVID-19 pandemic has significantly increased alcohol- related morbidity and mortality. There is a need to understand how emerging adults successfully reduce their alcohol use, factors that contribute to elevated alcohol risk, and opportunities for connecting high-risk emerging adults with evidence-based alcohol-related interventions. The proposed study will accomplish those goals by conducting detailed interviews with a group of racially and economically diverse emerging adult drinkers who have been enrolled in our longitudinal study of alcohol risk since prior to the pandemic, in order to understand pandemic impacts on drinking trajectories and factors promoting drinking reductions.

PI_NAMEs: MACKILLOP, JAMES ;MURPHY, JAMES G. (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: addiction;Address;Age;age group;Alcohol abuse;alcohol abuse therapy;alcohol consequences;Alcohol consumption;alcohol misuse;alcohol prevention;alcohol risk;alcohol risk reduction;alcohol-related death;Alcohols;Attention;Behavioral;behavioral economics;binge drinking;Black American;Black race;brief intervention;Classification;cohort;college;Communities;community setting;comorbidity;Coronavirus;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Collection;design;Development;drinking;Drug usage;Economics;Education;emerging adult;emerging adulthood;Enrollment;evidence base;experience;Feedback;Female;Funding;Goals;Grant;Health;help-seeking behavior;high risk;high risk drinking;high risk population;Home;Individual;Informal Social Control;insight;Institute of Medicine (U.S.);Intervention;intervention program;Interview;Knowledge;Life;Location;Longitudinal Studies;Modality;modifiable risk;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;Outcome;pandemic disease;pandemic impact;pandemic stress;Parents;Participant;participant enrollment;perceived discrimination;Persons;Pharmaceutical Preparations;Phase;Prevalence;Prevention;Prevention approach;Prevention program;preventive intervention;Process;protective factors;Public Health;Publications;Qualitative Methods;Qualitative Research;racial population;Recovery;Reporting;Research;Rewards;Risk;Risk Factors;social;Social support;Source;Stress;Subgroup;substance use;systemic barrier;trend;United States

PROJECT_TITLE: A Qualitative Analysis of Social and Behavioral Processes Associated with Self-Change in Drinking in an Existing Cohort of Black and White Emerging Adults

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Health Services;Rehabilitation;Telehealth

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative One goal of this research is to conduct a non-inferiority trial of telerehabilitation versus in-office care to provide follow-up training to individuals with low vision to enhance their quality of life by using magnification devices and/or visual assistive mobile apps for important daily activities, such as reading and/or other valued tasks. This is a high priority given the increasing prevalence of low vision, paucity of low vision rehabilitation providers, and barriers related to access to care, such as transportation and geography, which can be essentially eliminated with telerehabilitation. Another goal of this project is to determine whether significant changes in environmental data collected by Bluetooth low energy beacon sensors can be used as a solution to monitor and indicate when low vision patients’ have abandoned the use of their magnification devices, which has the potential to substantially enhance patient management by providing timely low vision rehabilitation services.

PI_NAMEs: BITTNER, AVA K (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: acceptability and feasibility;active control group;Activities of Daily Living;Address;Adherence;Agreement;Awareness;barrier to care;Bluetooth;Caring;Cellular Phone;Clinical;clinical practice;Computer software;Consult;Data;design;Devices;diaries;digital;Effectiveness;Electronics;Enrollment;environmental change;Equipment and supply inventories;Evaluation;Eyeglasses;follow-up;Frequencies;Funding;Geography;Goals;Health;Health Services;Health Services Accessibility;Home;Humidity;improved;improved outcome;Individual;interest;Intervention;Learning;Low Prevalence;Measures;Methods;mobile application;Modality;Monitor;Motion;novel;Office Visits;Optics;Outcome;Participant;patient population;Patient-Focused Outcomes;Patients;Pattern;Persons;portability;Positioning Attribute;primary outcome;Procedures;Provider;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Reading;reading ability;Records;recruit;rehabilitation service;rehabilitation strategy;Rehabilitation therapy;remote assessment;remote control;remote delivery;Reporting;Research;Resources;satisfaction;sensor;service delivery;Services;Site;Speech;System;Tablets;Technology;telehealth;telerehabilitation;Temperature;Testing;Text;Time;time use;Training;Transportation;treatment as usual;Validation;Videoconferencing;virtual platform;Vision;vision aid;vision rehabilitation;Visual;Visual Acuity;Visual Aid;Visual impairment;Work

PROJECT_TITLE: Beacon Sensors and Telerehabilitation to Assess and Improve use of Devices (BeST-AID) for Low Vision

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Dissemination and Implementation Research;Liver Disease;Rehabilitation;Substance Misuse

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Alcohol-associated liver disease is a consequence of alcohol use disorder in which decreasing alcohol use is critical for survival, yet few patients receive alcohol use disorder treatment. This proposal will investigate the integration of treatments for alcohol use disorder, including medications and brief counseling, into liver clinics using a combined approach including: determining the impact of medications for alcohol use disorder in patients with liver disease, assessing patient perspectives regarding receipt of integrated care for alcohol use disorder and alcohol-associated liver disease, and assessing the feasibility and acceptability of a method to help liver specialists provide alcohol use disorder care. The results of this work will inform interventions to improve outcomes in patients with alcohol use disorder and alcohol-associated liver disease through new integrated care models.

PI_NAMEs: HAQUE, LAMIA  (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: acceptability and feasibility;addiction;Adoption;Affect;alcohol abuse therapy;alcohol availability;alcohol consequences;Alcohol consumption;alcohol screening;alcohol use disorder;Alcoholic Liver Diseases;Alcohols;Area;Attitude;Behavior Therapy;Board Certification;Caring;Cessation of life;Cicatrix;Cirrhosis;Clinic;Clinical;clinical decision support;Clinical Trials;cohort;comparative effectiveness;cost effective;Counseling;Coupled;Data;Dedications;Deterioration;Development;Drug Prescriptions;Effectiveness;effectiveness/implementation trial;evidence base;Familiarity;feasibility testing;Foundations;Future;Goals;Guidelines;Health Professional;Health Services Research;Hepatic;Hepatology;implementation facilitation;implementation intervention;implementation science;implementation strategy;improved;improved outcome;integrated care;interest;Intervention;Interview;Laboratories;Lead;Liver;Liver diseases;liver function;liver transplantation;Medical;Medicine;Mentors;Methodology;Methods;Modeling;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;Patient Care;patient oriented;Patient Preferences;patient-level barriers;Patients;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacy facility;Pilot Projects;pilot test;Population;Positioning Attribute;preference;Questionnaires;Readiness;Recommendation;recruit;Research;Research Methodology;Research Personnel;Research Training;Resources;routine care;Severity of illness;social stigma;Specialist;Surveys;system-level barriers;tertiary care;Testing;Training;Treatment Efficacy;United States;uptake;user-friendly;Veterans Health Administration;Work

PROJECT_TITLE: Integrating Treatments for Alcohol Use Disorder into Hepatology Clinics

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases

ORG_CITY: GLENDALE

ORG_NAME: MIDWESTERN UNIVERSITY (GLENDALE AZ)

ORG_STATE: AZ

PHR: PROJECT NARRATIVE This project will provide foundational training that allows students and faculty to competently perform clinical practice-based research well into the future. Furthermore, it will provide applied training in conducting research through the launch of a large, multisite clinical study to assess the relationship between oral inflammation (OI) and functional gastrointestinal disorders (FGIDs), both of which affect up to 40% of populations worldwide. An unresolved connection is documented for OI and FGIDs and this clinical study will explore whether OI observed by dentists can be used to identify a patient’s likelihood of having or developing a FGID, providing information that patients can use to seek appropriate care or intervention.

PI_NAMEs: AGOSTINI-WALESCH, GINA ;MITCHELL, JOHN C (contact)

PROGRAM_OFFICER_NAME: GRISIUS, MARGARET

PROJECT_TERMS: Acute;Address;Affect;Applied Skills;Area;Award;Biological Sciences;career;Caring;Cell Nucleus;Chicago;Chronic;Clinic;Clinical;clinical examination;clinical practice;Clinical Research;clinical research site;clinical training;cohort;Collaborations;college;Consent;Data;Data Collection;data management;Data Reporting;Dental;Dental Schools;Dental Students;Dentistry;Dentists;design;Development;doctoral student;Education;Enrollment;Ensure;experience;Faculty;faculty mentor;Fostering;Functional Gastrointestinal Disorders;Future;Goals;Growth;Health;Incidence;Inflammation;Infrastructure;Institution;inter-institutional;Intervention;journal article;Knowledge;Laboratory Technicians;Measures;Medicine;meetings;member;Mentors;Mentorship;Methods;Mission;Multi-site clinical study;multidisciplinary;Nursing Faculty;operation;Oral;Oral health;Output;Participant;Patients;peer;peer coaching;Population;Practice based research;pre-doctoral;Primary Care;programs;prospective;Reaction;recruit;Research;Research Activity;research and development;research faculty;Research Personnel;Research Project Grants;research study;Research Training;Running;Schools;Severities;Site;skills;Social Sciences;Structure;Students;Supervision;System;Teacher Professional Development;Time;Training;Training Programs;Universities;University resources;Video Recording;Work

PROJECT_TITLE: Oral Inflammation and Functional Gastrointestinal Disorders: A Practice-Based Reseach Approach


ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative This proposal captures the plan for Weill Cornell Medicine’s first post-baccalaureate research education program to enhance diversity in biomedical research. Our program, ASPiRE (Advancing Success and Persistence in Research Education), encompasses experiential and didactic research education, professional development coaching, academic success coaching and tiered mentorship to produce future scientists and physician scientists from background underrepresented in science who will thrive and persist in academia.

PI_NAMEs: CARRASCO, YAZMIN PAULINA;FOUDA AMOU OU, GENEVIEVE GINY ;HOWELL, JOY DEANNA (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Academia;Academic Medical Centers;Academic skills;Address;Admission activity;Attenuated;Basic Science;Biological Sciences;Biomedical Research;Biometry;career;Career Choice;career development;cohort;Collaborations;college;Communication;Communities;community building;Development;Distant;diversity and inclusion;Doctor of Philosophy;doctoral student;Education;education research;Educational Curriculum;Enrollment;Ensure;equity, diversity, and inclusion;Event;experience;Exposure to;Faculty;faculty mentor;Foundations;fundamental research;Future;Goals;Graduate Education;graduate school;graduate student;Improve Access;Individual;Institution;interest;Interview;Investments;Journals;Knowledge;Laboratories;Literature;Longevity;medical schools;Medical Students;Medicine;meetings;member;Mentors;Mentorship;next generation;Pathway interactions;peer;peer coaching;Physicians;Population;Postbaccalaureate;Preparation;Process;programs;Psychologist;recruit;Reproducibility;Research;research faculty;Research Personnel;Research Training;responsible research conduct;Role;Science;Scientist;Self Efficacy;skills;sound;stem;STEM career;Structure;Students;success;Talents;Time;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;Universities;Writing

PROJECT_TITLE: Advancing Success and Persistence in Research Education (ASPiRE)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: PHARMACOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Treatments for age-related memory decline rely on understanding the basic mechanisms of hippocampal memory formation and storage over time. The proposed experiments will investigate these mechanisms using a novel method combining two-photon imaging and activity-dependent genetic strategies to identify and track populations of neurons storing episodic memories in the hippocampus. The conclusions from these experiments will advance current models of associative memory formation, ultimately contributing to a circuit-level understanding of memory in order to provide targets for intervention in treatments for memory deficits in aging.

PI_NAMEs: MONASTERIO, AMY  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Address;Affect;Age;age related;Age-associated memory impairment;age-related disease;Aging;Alzheimer's Disease;Area;awake;Behavior;Brain;Brain region;Calcium;career;cell type;Cells;cognitive function;Computer Models;Cues;Data;Disease;Educational process of instructing;Environment;Episodic memory;experience;experimental study;Faculty;Fellowship;FOS gene;Fostering;Functional disorder;Future;Genetic;genetic approach;Genetic Techniques;Goals;Grant;Health;Healthcare Systems;Hippocampus;Image;imaging approach;imaging genetics;Immediate-Early Genes;Impaired cognition;Impairment;in vivo;Individual;insight;Intervention;Job Application;Knowledge;Label;Learning;Life;life span;Memory;Memory impairment;Memory Loss;memory recall;memory retrieval;Mentors;Methods;Modeling;mouse model;Mus;Neurodegenerative Disorders;Neurons;Neurosciences;novel;novel strategies;optical imaging;Pattern;Phase;Physiology;Population;Postdoctoral Fellow;Preparation;Process;Professional Competence;Prosencephalon;recruit;Research;Research Personnel;Research Project Grants;Retrieval;Rodent;Role;Scientist;Societies;Structure;success;Synapses;Techniques;Technology;Testing;Time;Training;treatment strategy;two-photon;virus genetics

PROJECT_TITLE: Assessing the Dynamics of Hippocampal Neuronal Engrams in Memory Formation and Aging

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PI_NAMEs: THOMAS, ERIC J (contact)

PROGRAM_OFFICER_NAME: COSBY, KAREN

PROJECT_TITLE: A New Combination of Evidence Based Interventions to Improve Primary Care Diagnostic Safety and Efficiency: a Stepped Wedge Cluster RCT

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health

PHR: PROJECT NARRATIVE Guaranteed Basic Income (GBI) could address deep systemic social and structural inequities that lead to health disparities in Black youth, with potential to improve the financial, mental and physical well-being of Black emerging adults during their critical period of transition to independence. This study includes implementation and evaluation of an innovative, multilevel intervention to address grave inequities in health by providing GBI and access to financial coaching, peer-support, and real-time monitoring of needs and referral to services. The project will provide critical data needed to understand the potential of GBI for Black youth and how to maximize its impact on health with targeted programming at a time when multiple municipalities are considering GBI legislation.

PI_NAMEs: LIBBY, MARGARET ;LIGHTFOOT, MARGUERITA A.;LIPPMAN, SHERI ANN (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Accidental Injury;Acute;Address;Adult;Affect;Age;aged;Anxiety;arm;Behavior;Behavioral Research;Black race;black women;California;Cause of Death;Cellular Phone;Chlamydia;Cities;Communities;community partners;Coupled;critical period;Cross-Over Trials;Crossover Design;Data;depressive symptoms;design;Development;Discrimination;economic disparity;Economics;Education;education pathway;Effectiveness;emerging adult;emerging adulthood;Emotional;Employment;Enrollment;Ensure;Evaluation;experience;Exposure to;Family;Family Planning;follow-up;Future;Gonorrhea;Health;Health behavior;health disparity;health equity;health inequalities;Health Services Needs;help-seeking behavior;HIV Infections;HIV/STD;Human Papilloma Virus Vaccination;improved;Income;Individual;Inequity;innovation;insight;Intervention;Investments;Lead;Life;Low income;Low Income Population;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Monitor;Mood Disorders;multidisciplinary;Municipalities;Outcome;outcome disparities;Participant;payment;peer learning;peer support;Personal Satisfaction;Phase;physical conditioning;Policies;Policy Maker;Politics;Population;Populations at Risk;Poverty;programs;Psyche structure;Randomized;real time monitoring;Reduce health disparities;referral services;Reproductive Health Services;Research;response;Risk Taking;Savings;Science;Security;service gap;Service provision;service utilization;Services;sexual and reproductive health;social;social determinants;social health determinants;Statutes and Laws;Suicide;System;Testing;Time;Training;Training and Education;transition to adulthood;United States;Volatilization;White Women;Work;working group;young adult;Youth

PROJECT_TITLE: Increasing financial and health equity among low income black youth and young adults


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Sleep deprivation results in impairment in long-term potentiation (LTP) in the hippocampus. This proposal aims to uncover a specific molecular mechanism involving cAMP phosphodiesterase isoform PDE4A5 and its involvement in regulating AMPA receptors in b2AR-stimulated cAMP signaling concerning memory impairment in sleep deprivation. Unveiling this molecular mechanism could lead to novel pharmaceutical targeting and advancing current perspectives on neurological disorders involving memory impairment.

PI_NAMEs: ESTRADA-TOBAR, ZOILA MARIBEL (contact)

PROJECT_TERMS: A kinase anchoring protein;Acute;Adenylate Cyclase;Adrenergic Receptor;Affect;Agonist;Amino Acids;AMPA Receptors;Binding;Biological Assay;Brain Diseases;Cattle;Cell Culture Techniques;Chimeric Proteins;Co-Immunoprecipitations;Cognitive deficits;comparison control;Complex;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Detection;Disease;DLG4 gene;Doctor of Philosophy;Ectopic Expression;Excision;falls;Family;Fluorescence Polarization;Fluorescent Antibody Technique;Fostering;genetic regulatory protein;Glutamate Receptor;Goals;Hippocampus;Human;Image;imaging modality;Imaging Techniques;Impairment;In Vitro;in vivo;Isomerism;knock-down;Label;Learning;Link;Long-Term Potentiation;Major Depressive Disorder;Mediating;member;Membrane;Memory;Memory impairment;Molecular;Monitor;nano;Nervous System Disorder;Neurons;Norepinephrine;novel;optical sensor;optogenetics;pharmacologic;Pharmacologic Substance;Phase;phosphodiesterase IV;phosphoric diester hydrolase;Phosphorylation;Phosphotransferases;Play;polypeptide;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;postsynaptic;Postsynaptic Membrane;Process;Protein Isoforms;Proteins;Psyche structure;receptor;reconstitution;Regulation;Repression;Research;Rodent;Role;sensor;SH3 Domains;Signal Transduction;Site;Sleep Deprivation;Structural Protein;Structure;superresolution microscopy;Surface;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;tool;trafficking;ultra high resolution;Work

PROJECT_TITLE: Role of PSD-95-linked PDE4A5 in Regulation of AMPA Receptors


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: LOGAN

ORG_DEPT: BIOLOGY

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PHR: PROJECT NARRATIVE As we continue to fight to understand the opioid epidemic and a chronic pain crisis, a major avenue of research has remained glaringly under-investigated: the role of endogenous opioid peptides. This study will lay the long-overdue groundwork into investigating the role that the endogenous opioids play in mediating pain and the role they play in the sex differences that exist in pain and opioid analgesia.

PI_NAMEs: BOBECK, ERIN NICOLE (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: abuse liability;addiction;Affect;allostatic load;American;Amygdaloid structure;Anterior;antinociception;Automobile Driving;Behavioral;Binding;Biomedical Research;Brain;Brain region;Cell Nucleus;Central Nervous System;Chronic;chronic pain;cingulate cortex;Communication;Communities;delta opioid receptor;Dynorphins;endogenous opioids;Endorphins;Enkephalins;experimental study;Female;fighting;Gene Expression;genetic approach;In Vitro;Investigation;kappa opioid receptors;Knowledge;Label;Lead;male;Maps;Medial;Mediating;midbrain central gray substance;Molecular;Morphine;mRNA Expression;mu opioid receptors;Mus;neural;neural circuit;neuromechanism;Neurons;nociceptive response;Nucleus Accumbens;Opioid;Opioid agonist;Opioid Analgesics;opioid epidemic;opioid exposure;Opioid Peptide;Opioid Receptor;Output;Pain;pain behavior;Pain management;Pain Measurement;pain signal;Pathway interactions;Peptides;Pharmaceutical Preparations;Play;Prefrontal Cortex;Pro-Opiomelanocortin;Process;prodynorphin;proenkephalin;Property;Quantitative Reverse Transcriptase PCR;receptor;Receptor Activation;receptor expression;Research;response;Rewards;Role;sex;Sex Differences;sexual dimorphism;side effect;Specificity;Spinal Cord;Spinal cord posterior horn;Synapses;System;Therapeutic;Time;Tracer;Viral;Work

PROJECT_TITLE: Investigation of the endogenous opioid neural circuitry in pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: Columbus

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE People make thousands of daily choices and a long-term pattern of regular impulsive choices can lead to serious health challenges. This project will seek to improve time-based interventions and understand their neural mechanisms. The goal is to reduce impulsive choices to provide effective therapies for improving public health.

PI_NAMEs: SMITH, TRAVIS R (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Animals;Attention deficit hyperactivity disorder;Behavioral;Borderline Personality Disorder;Cognitive;comorbidity;Compulsive Behavior;Corpus striatum structure;Coupled;designer receptors exclusively activated by designer drugs;Diffusion Magnetic Resonance Imaging;Discrimination;Disease;Drug Exposure;effective intervention;effective therapy;endophenotype;experience;Functional disorder;Future;Gambling;Goals;Health;Human;improved;Impulsivity;Individual;Individual Differences;innovation;Intervention;intervention effect;Link;maladaptive behavior;Measures;Medial;Mental Depression;Mental disability;Mental disorders;Mission;Modeling;National Institute of Mental Health;neural;neurobiological mechanism;Neurobiology;neuromechanism;novel;Obesity;Parkinson Disease;Pathological Gambling;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;Pre-Clinical Model;Process;programs;Progress Reports;Public Health;Rattus;Research;reward processing;Rewards;Rodent;Rodent Model;Role;Schizophrenia;Self Administration;Self-control as a personality trait;Substance abuse problem;substance abuse treatment;System;Techniques;Testing;therapeutic candidate;Therapeutic Intervention;Time;translational applications;Translational Research;Treatment outcome

PROJECT_TITLE: Timing, reward processing and choice


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The goal of this work is to increase our understanding of the genetic predispositions underlying FASD and to uncover novel pathogenic mechanisms in order to aid in prevention and intervention efforts. We will use genomic, transcriptomic, and chemical interactions in zebrafish and mice to discover novel candidate genes that modify susceptibility to early gestational ethanol exposure. Subsequent experiments will use gene editing in zebrafish and mice to further confirm candidate genes that may interact with ethanol.

PI_NAMEs: EBERHART, JOHANN K;PARNELL, SCOTT  (contact);TARANTINO, LISA M

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: Affect;alcohol effect;alcohol exposure;alcohol sensitivity;Alcohols;Animal Model;Bioinformatics;Biological Assay;Brain;brain abnormalities;brain malformation;C57BL/6N Mouse;Candidate Disease Gene;candidate identification;Cell Line;Central Nervous System;Chemical Modifier;Chemical-Induced Change;Chemicals;Collaborations;Congenital Abnormality;Craniofacial Abnormalities;CRISPR/Cas technology;Crossbreeding;Data;Development;differential expression;Embryo;Embryology;Embryonic Development;Ethanol;experimental study;Face;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fishes;Functional disorder;gene conservation;Gene Expression;Gene Modified;gene-editing approach;Genes;Genetic;genetic analysis;Genetic Predisposition to Disease;Genetic Screening;genome sequencing;Genomics;Goals;Human;improved;Individual;insight;interest;Intervention;Knowledge;Laboratories;Maps;Mediating;Modeling;mouse genetics;mouse model;Mouse Strains;Mus;mutant;Mutation;Nature;next generation sequencing;novel;Nutritional;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;Play;Predisposition;Pregnancy;Prevention;Quantitative Trait Loci;Rapid screening;Reader;resilience;Resistance;resistant strain;Resources;Risk;Role;Techniques;Technology;teratogenesis;Teratogens;Teratology;Testing;Tissue-Specific Gene Expression;tool;Transcription Alteration;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;Transgenic Mice;Transgenic Organisms;Variant;Work;Zebrafish

PROJECT_TITLE: Characterizing the Genetics of FASD in Complementary Mouse and Fish Models


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: EDINBURG

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

PHR: Public Health Relevance Statement (Project Narrative) Chronic pain is a major health condition in people living with Human Immunodeficiency Virus-1 (PLWH) in the combined antiretroviral therapy (ART) era, but the current pharmacologic therapies are not effective in managing chronic neuropathic pain, and side effects are common. The development of new and effective therapeutic tools has been hampered in part by the lack of a suitable animal model that can mimic the HIV-related chronic neuropathic pain condition. The characterization that EcoHIV-infected mice develop a neuropathic pain-like condition with behavioral and pathological changes that mimic neuropathic pain in PLWH will advance the fields of HIV and pain by laying the groundwork for urgently needed therapeutic and mechanistic studies.

PI_NAMEs: BENAMAR, KHALID  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute;Address;Adherence;Affect;Age;age difference;allodynia;Analgesics;Animal Model;Animals;antiretroviral therapy;approach behavior;Area;Behavior;Behavior assessment;behavior test;Behavioral;Biochemistry;Biological;CD4 Positive T Lymphocytes;Cells;Characteristics;Chronic;chronic neuropathic pain;chronic pain;Clinical;Clinical Data;Cognitive deficits;comorbidity;cost;density;Development;DNA;Dysesthesias;Ensure;Esthesia;Female;Genetic Transcription;Glycoproteins;Health;health care availability;Histopathology;HIV;HIV diagnosis;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;human old age (65+);Hypersensitivity;Individual;Infection;Injections;interdisciplinary approach;Intraperitoneal Injections;Knowledge;Light;Longitudinal Studies;Maintenance;male;mechanical allodynia;Mental Depression;midbrain central gray substance;Modeling;Molecular Biology;Mus;Needles;Nerve Fibers;neuroinflammation;Neuropathy;Outcome;Pain;pain model;pain sensation;painful neuropathy;Pathologic;Patients;Peripheral Nervous System Diseases;Persistent pain;Persons;pharmacologic;Pharmacology;Physical Function;Prevalence;Proteins;public health relevance;Quality of life;receptor;Reporting;Research;response;Role;Sensory;Severities;sex;Sex Differences;side effect;skin biopsy;Spinal Cord;Stimulus;substance use;Testing;Therapeutic;therapeutic development;Therapeutic Studies;therapeutically effective;tool;Touch sensation;Trans-Activators;Transcription Coactivator;Vaccines;Viral;Viral Proteins

PROJECT_TITLE: EcoHIV and neuropathic pain

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE: Triple-negative breast cancer (TNBC) is a problematic, aggressive, and unpredictable subtype of invasive breast cancer associated with a high systemic recurrence rate with lethal metastasis. Currently, there are very few effective drugs approved by the FDA for the treatment of patients with advanced TNBC. In this project, we will investigate the activity of an experimental compound named LG007 and determine its potential as a new drug candidate for the treatment of TNBC.

PI_NAMEs: XI, YAGUANG  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: 4T1;Adjuvant;African American;Age Years;Animal Model;anticancer activity;Biological Assay;Biological Markers;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Model;Cancer Patient;cancer subtypes;Cause of Death;Cells;Chemotherapy-Oncologic Procedure;Clinical;clinical application;Clinical Trials;Communities;comparative efficacy;Data;Death Rate;Development;Diagnosis;Disease;drug candidate;drug development;Drug Kinetics;Early treatment;economic disparity;effective therapy;efficacious treatment;efficacy evaluation;epidemiology study;Epidermal Growth Factor Receptor;ERBB2 gene;Estrogen Receptors;ethnic minority population;Ethnic Origin;Evaluation;experience;Experimental Designs;experimental study;FDA approved;Future;gain of function;Guidelines;health disparity;High Prevalence;Hispanic Women;Human;In complete remission;in vitro activity;in vivo;Incidence;interest;Invaded;Investigation;Lead;loss of function;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Medical;MicroRNAs;Modeling;Molecular Mechanisms of Action;mouse model;Mus;Names;Neoadjuvant Therapy;Neoplasm Metastasis;novel;novel therapeutics;Oncogenic;Paclitaxel;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacology;Pharmacology and Toxicology;Predisposition;Preparation;Progesterone Receptors;Prognosis;Property;Recurrence;Recurrent disease;Research;research clinical testing;Role;Safety;Sampling;screening;social disparities;socioeconomics;Specificity;Sulindac;targeted treatment;Testing;Therapeutic Agents;therapeutically effective;Tissue Microarray;tool;Toxic effect;Toxicology;transcriptome sequencing;Translating;Translations;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Promotion;tumor xenograft;United States;White Women;Woman;Work;young woman

PROJECT_TITLE: Developing LG007 as a novel therapeutic agent to treat triple negative breast cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Nanotechnology;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: As the most common group of inherited retinal degenerations, retinitis pigmentosa (RP) affects about 1.5 million people worldwide. This proposal aims to establish a human retinal organoid model system that recapitulates BBS7, a particularly severe form of RP, to allow for the investigation into mechanistic causes and therapeutic rescue of this disease. These studies will provide an excellent mentored training experience in translational research and will generate a pipeline for therapeutic gene editing to treat individuals with severe inherited retinal diseases.

PI_NAMEs: CHIRCO, KATHLEEN R (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Accounting;adenovirus mediated delivery;Affect;autosome;Bardet-Biedl Syndrome;Biological Models;Cell Physiology;Cells;Cilia;ciliopathy;clinic ready;Complex;CRISPR/Cas technology;cytotoxic;Defect;Development;Disease;disease model;disease phenotype;Disease Progression;disease-causing mutation;Dose;effective therapy;Evaluation;experience;experimental study;Formulation;Functional disorder;Future;gene-editing approach;Genes;genome editing;genome editor;Goals;Growth;Human;human induced pluripotent stem cells;immunogenicity;Immunologics;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inherited;inherited retinal degeneration;Investigation;Knowledge;Lead;Life;Link;lipid nanoparticle;Measures;Mediating;Membrane;Mentors;Methods;Modeling;Morphogenesis;Mutation;nanoparticle delivery;nonhuman primate;novel;optimal treatments;Organoids;Persons;Phenotype;photoreceptor degeneration;Photoreceptors;postmitotic;prevent;prime editing;prime editor;protein transport;Retina;Retinal Degeneration;Retinal Diseases;Retinitis Pigmentosa;Safety;side effect;Specificity;System;Testing;Therapeutic;therapeutic genome editing;timeline;tool;Training;translational model;Translational Research;treatment optimization;Validation;Variant;Vision research;Work

PROJECT_TITLE: Establishing a novel gene editing strategy for BBS7 using human retinal organoids

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Cancer;Liver Disease;Prevention;Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Narrative Hepatocellular carcinoma is one of few cancers with a rising incidence a rise that disproportionally affects ethnic minorities and rural residents, however, known risk factors including viral hepatitis, fatty liver disease and cirrhosis cannot fully explain these disparities. Environmental contaminants such as cadmium are common pollutants, ranked in the top ten chemicals of concern, and can cause cancer in animals. We will create a cohort of 16,000 participants to determine whether exposure to multiple common environmental contaminants increases liver cancer risk, whether risk differentially impacts rural and ethnic minorities, and whether epigenetic mechanisms mediate these associations.

PI_NAMEs: HOYO, CATHRINE  (contact);MOYLAN, CYNTHIA A;SCHILDKRAUT, JOELLEN M.

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: Address;Adult;Adverse effects;Affect;African American population;Age;aged;Air;Alcohol consumption;alcohol exposure;Animals;Arsenic;bioaccumulation;Biological Specimen Banks;Body Burden;Cadmium;cancer diagnosis;Cancer Etiology;cancer risk;Carcinogens;case control;Case/Control Studies;Cessation of life;Chemicals;Chronic;Cirrhosis;Classification;cohort;Communities;community clinic;Data;Data Collection;data modeling;data repository;design;disease registry;Disparity;DNA Methylation;Dose;Environment;environmental chemical;Environmental Exposure;Environmental Pollutants;Epigenetic Process;ethnic diversity;ethnic minority;Ethnic Origin;Excretory function;exposed human population;Exposure to;Fatty Liver;fatty liver disease;Federally Qualified Health Center;Female;Fibrosis;follow-up;Food Packaging;General Population;Geography;Health;Health system;Hepatology;Hispanic Americans;House Dust;Human;human data;Incidence;Industrialization;insight;International Agency for Research on Cancer;Knowledge;Link;Liquid substance;Liver;Liver Cirrhosis;Liver diseases;Liver Fibrosis;Longitudinal cohort study;male;Malignant neoplasm of liver;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Metals;Molecular;mouse model;Mycotoxins;National Health and Nutrition Examination Survey;Nested Case-Control Study;non-alcoholic;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;North Carolina;Not Hispanic or Latino;Obesity;Outcome;Participant;participant enrollment;Phase;Poison;pollutant;Poly-fluoroalkyl substances;Population Heterogeneity;Prevalence;Primary carcinoma of the liver cells;Primary Care;Primary Malignant Neoplasm of Liver;Probability;programs;progression risk;Protocols documentation;recruit;Reporting;Research;Resources;response;Risk;Risk Factors;Role;Rural;rural dwellers;Rural Minority;Sampling;sex;Source;Susceptibility Gene;Testing;Textiles;Time;toxic metal;United States;Universities;Variant;Viral hepatitis;Water

PROJECT_TITLE: Southern Liver Health Cohort


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Prevention;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE Humans are exposed to large numbers of physical and chemical substances. However, it is unclear what exposures may increase the risk of cancers. Herein, we propose a research program to address critical issues in environmental epidemiology of cancer and establish a large cohort study in low-income and minority populations to systematically investigate environmental exposures for cancer risk.

PI_NAMEs: SHRUBSOLE, MARTHA J.;ZHENG, WEI  (contact)

PROGRAM_OFFICER_NAME: MAHABIR, SOMDAT

PROJECT_TERMS: Address;Behavioral;Biological;Biological Markers;Biological Specimen Banks;biomarker identification;Blood specimen;built environment;cancer epidemiology;Cancer Etiology;cancer risk;carcinogenesis;carcinogenicity;Carcinogens;Chemicals;cohort;Cohort Studies;Collection;Communities;community engaged research;Coupled;Data;Disease;disorder risk;Dose;Environment;environment related cancer;Environmental Carcinogens;Environmental Epidemiology;Environmental Exposure;Environmental Health;Environmental Pollutants;epidemiology study;Ethnic Origin;Evaluation;experience;exposed human population;Exposure to;follow-up;Funding;Future;Geography;Health;health inequalities;Human;improved;Incidence;Individual;Infrastructure;instrument;Investigation;Life Cycle Stages;Link;Low income;Malignant neoplasm of lung;Malignant Neoplasms;Measures;metabolomics;Minority Groups;mortality;multiple data sources;novel;Obesity;Occupational;Outcome;Participant;Persons;Phenotype;physical inactivity;Pollution;Predisposition;programs;Protocols documentation;Race;Recording of previous events;recruit;remediation;Research;Resources;response;Risk;Risk Factors;sample collection;Sampling;social;success;Surveys;Time;Tobacco smoking behavior;tool;Unhealthy Diet;unhealthy lifestyle;Variant;wearable device

PROJECT_TITLE: Southern Environmental Health Study


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Many motor neuron diseases (MNDs) such as spinal muscular atrophy (SMA) and some forms of amyotrophic lateral sclerosis (ALS) result from minor genetic mutations that cause damage and cell-death in a largely similar set of tissues, thus a method to genomically correct MND mutations in affected tissues could therapeutically treat MNDs of many genetic origins. Clarity on the determinants of base editing outcomes is much needed to efficiently and precisely correct disease-relevant single nucleotide mutations that are intractable to conventional base editing tools, including many MND targets such as the pathogenic SMA allele and the ALS SOD1A4V mutation. By thorough characterization of base editor variants, and establishing an effective method to deliver genome editing tools to MND relevant tissues in vivo, we will create a general pipeline to design and validate optimized base editing strategies to correct causal MND mutations for the development of a therapeutic treatment for SMA and other genetic MNDs.

PI_NAMEs: ARBAB, MANDANA  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Acceleration;Address;adenovirus mediated delivery;Adult;Affect;Alleles;Amyotrophic Lateral Sclerosis;Animal Model;Antisense Oligonucleotide Therapy;Award;base editing;base editor;BCAR1 gene;causal variant;Cell Death;Central Nervous System;Chimeric Proteins;Clinic;Communication;community based research;Complex;Data;data visualization;Deaminase;design;Development;Disease;disease model;disease phenotype;disease-causing mutation;Disease-Free Survival;DNA Sequence Alteration;Environment;Enzymes;experimental study;Faculty;familial amyotrophic lateral sclerosis;Foundations;Funding;Future;gene correction;Genes;Genetic;genetic variant;Genome;genome editing;genomic locus;Genomics;Genotype;Goals;Grant;Human;improved;In Vitro;in vivo;Individual;Injections;Late-Onset Disorder;Learning;Libraries;machine learning prediction;Mammalian Cell;meetings;member;Mentorship;Methods;Minor;Modeling;Molecular Abnormality;molecular pathology;molecular phenotype;Motor Neuron Disease;Motor Neurons;Mouse Embryonic Stem Cells;mouse model;Mus;mutant;Mutation;Neonatal;Neurodegenerative Disorders;North America;novel;Nucleotides;Other Genetics;Outcome;Pathogenicity;Patients;Peripheral;Phenotype;Point Mutation;Positioning Attribute;predictive modeling;Procedures;progressive neurodegeneration;Protocols documentation;Publishing;Research;Research Personnel;Route;Safety;Science;screening;Serotyping;skills;Spinal Muscular Atrophy;success;symposium;System;Techniques;Testing;Therapeutic;therapeutic development;therapeutic genome editing;Therapeutic Intervention;Tissues;tool;Translating;transversion mutation;Treatment Efficacy;United States National Institutes of Health;Validation;Variant;Work;Writing

PROJECT_TITLE: Precision Base Editing for the Treatment of Motor Neuron Diseases

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Aging;Biotechnology;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Senescence is a terminal cellular state that contributes to many human diseases. Identification and mapping of senescent cells in tissues will help understand the mechanisms of diseases, with the potential to discover novel disease therapies. We propose to employ a newly invented single-cell proteomic approach to investigate the proteomes of senescent cells in the lungs to reveal novel markers of senescent cells. The identified novel markers will facilitate our understanding of lung biology and disease, and further promote the identification and characterization of senescent cells in other human tissues.

PI_NAMEs: DOU, ZHIXUN  (contact);RAJAGOPAL, JAYARAJ ;SLAVOV, NIKOLAI

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: 3-Dimensional;Address;aged;Aging;Autophagocytosis;Behavior;beta-Galactosidase;Biological Models;Biology;biomarker identification;biomarker panel;CDKN2A gene;Cell Aging;Cell Cycle Arrest;cell type;Cells;Chromatin;cohort;Cytolysis;Cytoplasm;data acquisition;Data Analyses;Detection;detection sensitivity;Disease;Disease Progression;Embryonic Development;embryonic stem cell;Flow Cytometry;Gamma-H2AX;General Hospitals;Goals;Harvest;Heterogeneity;Human;human disease;human tissue;Impairment;improved;Inflammation;Inflammatory;Inflammatory Response;innovation;Institutional Review Boards;Intervention;invention;Lamin B1;Lung;Lung Diseases;Macrophage;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Massachusetts;Mission;Mus;New England;new technology;novel;novel marker;Nuclear;old mice;Pathologic;Pathway interactions;Phase;Population;Procedures;protein complex;Proteins;Proteome;Proteomics;Protocols documentation;Research Personnel;Resolution;senescence;senescent cell;Services;single-cell RNA sequencing;SIRT1 gene;Specimen;stem cell differentiation;Stimulator of Interferon Genes;Structure of parenchyma of lung;Technology;telomere damage;Testing;tissue mapping;tissue preparation;tissue regeneration;Tissues;tool;tumorigenesis;wound healing

PROJECT_TITLE: Single-cell proteomic identification of novel markers of senescence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(70)R]


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Project Narrative Training and skills development in clinical dental research are imperative to continued improvements in the quality of oral health care in the US, yet dental schools, residency programs, and clinical faculty are generally lacking in this area. Our proposal aims to improve the current state of such training through development of a 2- year MS in Clinical Dental Research, a Clinical Research Resource Network and Resource Center, a Mentorship Pathway, a regional clinical research symposium, and a multi-site developmental clinical study seeking to improve treatment for dental implant patients. Our multidisciplinary, practice-based research incubator is relevant to the NIDCR’s mission in that it will create the next generation of dental clinician-scientists who will create, improve, and deliver evidence-based care for our patients.

PI_NAMEs: SCHOENBAUM, TODD  (contact)

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: Academia;Address;Area;bone loss;career;Caring;Clinical;Clinical Investigator;Clinical Research;clinical research site;clinical training;Collaborations;college;Dental;Dental General Practice;Dental Implants;Dental Research;Dental Schools;Dental Specialties;Dental Students;Dentists;Development;Doctor of Philosophy;Ensure;evidence base;experience;Faculty;Failure;Funding;Future;Goals;Grant;Healthcare;Implant;improved;Incubators;Inflammation;inflammatory marker;innovation;Institution;Instruction;Investigation;Leadership;Medical Faculty;medical schools;Mentors;Mentorship;Mission;Modality;Multi-site clinical study;multidisciplinary;multimodality;Multiple Partners;National Institute of Dental and Craniofacial Research;next generation;Nursing Faculty;Oral health;Outcome;Outcome Study;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Play;Positioning Attribute;Practice based research;primary outcome;Productivity;prognostic value;programs;recruit;repository;Research;Research Personnel;research study;Research Training;Residencies;Resources;Risk;Role;Saliva;Salivary;Science;Scientist;Site;skill acquisition;Societies;square foot;student training;Students;success;symposium;Teacher Professional Development;Training;training opportunity;Training Programs;Treatment outcome;Universities;Work

PROJECT_TITLE: Clinician-Scientist Research Incubator for Practice-based Training (Clin.ScRIPT)


ADMINISTERING_IC: LM

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Albany

ORG_NAME: BERKELEY MADONNA, INC.

PHR: Project Narrative This proposal will expand the functionality of the mathematical software Berkeley Madonna to perform medical decision analysis and cost-effectiveness analysis using microsimulation and Markov cohort analysis. Successful completion of our goals will provide a powerful, user-friendly, transparent, and affordable piece of software for users in this growing field to more easily construct and simulate decision models and positively impact health outcomes.

PI_NAMEs: NAYAK, SMITA  (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Acceleration;Achievement;Adjusted Life Years;Adverse event;analytical method;burden of illness;Caring;Characteristics;Clinical Trials;Code;cohort;Cohort Analysis;Communities;Complex;Computer Models;Computer software;computerized tools;cost;Cost Effectiveness Analysis;Coupled;Decision Analysis;Decision Making;Decision Modeling;Decision Trees;design;Development;Differential Equation;Disease;Educational process of instructing;Effectiveness;Elements;Event;Evidence Based Medicine;Evidence based practice;experience;Explosion;Face;flexibility;Functional disorder;Goals;Graph;graphical user interface;Growth;Health;health assessment;Health Care Costs;Healthcare;Healthcare Systems;Human;Image;incremental cost-effectiveness;Individual;individual patient;Industry;interest;Intervention;Intuition;Knowledge;Letters;Link;mathematical model;Mathematics;Measures;Medical;Medical Research;Methods;model building;Modeling;multithreading;Outcome;Output;parallelization;Patients;Performance;Phase;Physicians;Physiology;portability;Probability;programs;Publishing;Pythons;Quality-Adjusted Life Years;recruit;relative cost;Reporting;Research;Research Personnel;Running;simulation;simulation software;Small Business Innovation Research Grant;Speed;stem;success;syntax;System;Technology;Testing;Time;tool;treatment choice;treatment strategy;Trees;Uncertainty;user-friendly;Work

PROJECT_TITLE: Quantitative Modeling Software with Applications to Medical Decision Making