NIH_SPENDING_CATS: Bioengineering;Digestive Diseases

PHR: Project Narrative Core B has proven to be and remains an essential and highly utilized component of the Harvard Digestive Diseases Center that significantly benefits its members. Core B is additionally relevant because it supports biomedical research that is funded by the NIH and has already been judged as important to understanding the pathogenesis or treatment of human diseases of the GI tract and liver.

PI_NAMEs: THIAGARAJAH, JAY  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Area;Biological;Biology;Biomedical Research;Board Certification;Boston;Categories;Clinical Research;Collaborations;Computers and Advanced Instrumentation;Confocal Microscopy;Consultations;Core Facility;cost;Development;Digestive System Disorders;Documentation;Electron Microscopy;Emerging Technologies;Epithelium;Equipment;experience;Experimental Designs;Faculty;Financial Support;Funding;Future;Gastrointestinal Surgical Procedures;Gastrointestinal tract structure;Grant;gut microbes;Histology;Histopathology;Hospitals;Hour;Human;human disease;Image;Image Analysis;image processing;Imaging technology;Immune;immunocytochemistry;Infrastructure;innovation;Institution;instrumentation;interest;Investigator-Initiated Research;Israel;Liver;Location;Medical center;medical schools;member;Metabolism;Methods;microbial;Microscope;Microscopy;Mission;Mucosal Immunity;Mucous Membrane;Mus;nanoscale;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;Optics;Paper;Pathogenesis;Pathologist;Pediatric Hospitals;Productivity;programs;Qualifying;Research;research and development;Research Personnel;Resolution;Resources;Rodent;Science;Services;Site;stem cell biology;Structure;Surface;System;Techniques;Technology;Training;Translational Research;United States National Institutes of Health;Update;Woman;Work

PROJECT_TITLE: Microscopy and Histopathology Core B


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative The Gateway to Global Aging Data is a data and information platform developed to facilitate longitudinal and cross-country analyses on aging, especially the Health and Retirement Study and its International Network of Studies (HRS-INS) around the world (19 surveys in 47 countries). The Gateway makes analyses of HRS-family surveys across time and countries much easier, lowering the costs of entry for new researchers and saving time and effort even for experienced researchers. The proposed expansion to include additional longitudinal surveys, the Harmonized Cognitive Assessment Protocol (HCAP), the COVID-19 surveys, and two new surveys in Brazil and Chile will help numerous interested researchers and thereby accelerate the speed of scientific discoveries in late-life cognition and dementia.

PI_NAMEs: ADAR, SARA ;GROSS, ALDEN L.;LEE, JINKOOK  (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Acceleration;Address;Aging;Air Pollution;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;base;Brazil;Caring;Characteristics;Chile;Code;Cognition;cognitive testing;Cohort Studies;Collaborations;Communities;cost;Country;COVID-19;COVID-19 pandemic;Data;data dissemination;data infrastructure;data integration;data management;data platform;data resource;Data Set;Databases;Dementia;dementia care;dementia risk;design;Economics;Educational process of instructing;Educational workshop;Elements;end of life;end of life care;Environmental Risk Factor;experience;Family;Fostering;Funding;Goals;Growth;Health;Health and Retirement Study;health data;Impaired cognition;improved;Individual;Infrastructure;innovation;insight;Institution;interest;International;interoperability;Interview;Investments;Knowledge;late life;life history;Long-Term Care;Long-Term Effects;longitudinal analysis;Longitudinal Surveys;Measures;Metadata;mild cognitive impairment;Mission;modifiable risk;Names;National Institute on Aging;novel;older adult;outreach;Particulate;Personal Satisfaction;Policies;Pollution;Population;population health;Process;Protocols documentation;psychosocial;Publications;Questionnaires;Research;research and development;Research Personnel;Resources;Respondent;Retirement;Risk;Sampling;Schedule;Source;Speed;Standardization;Surveys;symposium;synthetic data;Time;Training;usability;webinar

PROJECT_TITLE: Integrating Information about Aging Surveys: Novel Integration of Contextual Data to Study Late-Life Cognition and Alzheimer’s Disease and Related Dementia and Dementia Care

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Pediatric;Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE This proposal seeks support for a new Child Health Research Career Development Award (CHRCDA) Program to be established at the University of California, San Diego (UCSD) Department of Pediatrics entitled “Developing Diverse Physician-Investigator Leaders for the Future of Child Health”. Promising junior faculty Pediatric Physician-Investigators will receive intensive leading-edge basic research training in world-class laboratories of prolific scientist mentors across a broad range of important topics central to child health and development. This experienced will be integrated with a variety of formal, high quality proven career development activities to ensure successful advancement in academic pediatric medicine.

PI_NAMEs: HADDAD, GABRIEL G (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Basic Science;Big Data;Biomedical Research;Brain;California;career;career development;Child Health;Childhood;Communities;Country;Coupled;Development;Educational Curriculum;Educational workshop;experience;Faculty;faculty mentor;Funding;Future;Genomics;Health;Health Sciences;Human Microbiome;Immunity;Infection;Inflammation;K-Series Research Career Programs;Leadership;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Metabolism;minority investigator;Neurosciences;Organ;Pathway interactions;pediatric department;Pediatric Hospitals;pediatrician;pediatrician scientist;Pediatrics;Philosophy;Physicians;Physiology;programs;Research;Research Personnel;Research Training;Role;Scientist;stem cell biology;Structure;success;Systems Biology;Training;training opportunity;translational research program;United States National Institutes of Health;Universities;Woman


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PI_NAMEs: MAJOR, MICHAEL BENJAMIN (contact)

PROJECT_TERMS: Biological Assay;Biological Process;Clinical;Clinical Research;Collaborations;Complications of Diabetes Mellitus;Consult;cost;cost effectiveness;Dedications;Development;Diabetes Mellitus;diabetes pathogenesis;diabetic;Endocrine System Diseases;Ensure;Environment;Funding;Goals;Homeostasis;Hour;Individual;Infrastructure;Institution;instrument;instrumentation;Investments;Isotopes;Laboratories;Lipids;MALDI-TOF Mass Spectrometry;Mass Fragmentography;Mass Spectrum Analysis;Measurement;member;metabolic abnormality assessment;Metabolic Diseases;Metabolic Pathway;Metabolism;metabolomics;Methods;Molecular;Names;novel strategies;Paper;Pathogenesis;Pathway interactions;Phosphorylation;Post-Translational Protein Processing;Prevention strategy;programs;protein expression;protein function;protein protein interaction;Proteins;Proteomics;Publications;recruit;Research;Research Personnel;Risk Factors;Role;Sampling;Services;Signal Transduction;Specialist;Spectrometry, Mass, Electrospray Ionization;Standardization;Students;Surveys;System;tandem mass spectrometry;time of flight mass spectrometry;Training;Translating;Universities;Washington

PROJECT_TITLE: Mass Spectrometry


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: CARSTENSEN, LAURA L (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Absenteeism;Adult;age difference;Aging;Behavioral;behavioral study;Characteristics;Child;Cognitive;cognitive benefits;Communities;cost;Crime;density;Elderly;Emotional;emotional functioning;Emotions;experience;Family;Fostering;Funding;Goals;grandchild;grandparent;Grant;Health;healthy lifestyle;high risk;Household;human capital;human old age (65+);Incentives;Individual;Instruction;Intervention;Investments;Measures;Modernization;Motivation;Neighborhoods;older adult;Older Population;Outcome;Pathway Analysis;Pattern;Personal Satisfaction;Population;preference;programs;protective effect;Qualitative Research;Quasi-experiment;Research;Resources;Role;satisfaction;Schools;Series;social;social capital;social cohesion;Social Development;Social Environment;Social Network;social norm;social structure;Societies;Source;Surveys;Testing;theories;Time;volunteer;Well in self;Workplace

PROJECT_TITLE: Socioemotional Functioning in Adulthood and Old Age

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: TAMPA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Kidney transplantation is a life-saving procedure for patients with end-stage kidney disease, however, the long-term survival shows only a small improvement in recent decades, with a half-life of about 10 years and organ shortage is a global crisis. The present proposal will examine the significant role of macula densa NOS1 on the long-term renal graft function.

PI_NAMEs: WANG, LEI  (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: Bicarbonates;Cardiac Death;Conscious;Data;delayed graft function;Deterioration;Employment;End stage renal failure;Exhibits;experience;experimental study;Feedback;Generations;Glomerular Filtration Rate;graft function;Graft Survival;Half-Life;hemodynamics;improved;In Vitro;in vitro activity;in vivo;Incidence;Injury to Kidney;Intake;Ischemia;Kidney;Kidney Transplantation;Life;Macula densa;Measurement;Measures;Mediating;Methods;Mus;Neurons;Nitric Oxide Synthase;Nitric Oxide Synthase Type I;NOS1 gene;novel;novel strategies;Organ;Organ Donor;Organ Survival;Organ Transplantation;Outcome;Patients;Play;post-transplant;Prevention;Prevention strategy;Procedures;protein purification;Renal function;Reperfusion Injury;response;Risk Factors;RNA Splicing;Role;Survival Rate;Testing;therapeutic target;translational potential;Transplantation;Variant;Wild Type Mouse

PROJECT_TITLE: Macula densa NOS1 and transplanted renal graft function

STUDY_SECTION: KMBD

STUDY_SECTION_NAME: Kidney Molecular Biology and Genitourinary Organ Development[KMBD]


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PI_NAMEs: LENCER, WAYNE I (contact)

PROJECT_TERMS: Acceleration;access restrictions;Address;Area;Biochemical;Biological;Biology;Boston;Carrier Proteins;Cell Culture Techniques;Cell Physiology;Cell Separation;Cells;Cellular biology;Cellular Metabolic Process;Chemistry;Clinical;Colon;Colonoscopes;Communities;Consumption;Core Facility;cost;Development;Developmental Cell Biology;Digestive System Disorders;Educational process of instructing;Electrophysiology (science);Emerging Technologies;endoplasmic reticulum stress;Epithelial Cells;Epithelium;Equipment;Expression Profiling;extracellular;Faculty;faculty mentor;Flow Cytometry;Fluorescence;Future;Gastrointestinal tract structure;Grant;gut inflammation;Hospitals;Hour;Human;Immune;Immunology;Infrastructure;innovation;Institution;Intestines;lipid transport;luminescence;Measures;member;Membrane Proteins;Metabolic;Metabolism;microbial;Microbiology;Mission;Molecular;monolayer;Mucosal Immunity;Mucositis;Mucous Membrane;Mus;Natural Immunity;Neurobiology;new technology;next generation sequencing;Organoids;Paper;Pathogenesis;Pediatric Hospitals;Peptides;Productivity;protein expression;protein transport;Proteins;Publishing;Recombinant Proteins;Research;research and development;Research Personnel;Resources;response;RNA;Science;Services;single cell sequencing;single cell technology;small molecule;solute;stem cell biology;stem cell organoids;stem cells;Surface;Technology;Tissues;Training

PROJECT_TITLE: Epithelial Cell and Mucosal Immunology Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Substance Misuse;Women's Health Research

ORG_CITY: PESSAC

ORG_COUNTRY: FRANCE

ORG_FIPS: FR

ORG_NAME: ADERA

PHR: PROJECT NARRATIVE Clinical and operational research assessing the efficiency of HIV care programs require reliable information systems and capacity building for sustaining this activity in the long term. The IeDEA West Africa collaboration has already implemented a network of HIV care centers in eight countries within West Africa that will continued to be used for this primary purpose. It will also reinforce its commitment to study specific comorbidities (tuberculosis) and emerging health events in chronic HIV care including cancer, mental health and other non- communicable diseases. Follow-up of HIV-infected vulnerable populations including children, adolescents and women of reproductive age will be strengthened and a specific research agenda on key population initiated.

PI_NAMEs: EKOUEVI, DIDIER KOUMAVI;JAQUET, ANTOINE  (contact);OFOTOKUN, IGHOVWERHA

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;Adolescent;Adult;Affect;Africa;African;Age;Aging;AIDS population;Algorithms;antiretroviral therapy;Anxiety;Burkina Faso;Caring;Cervical Cancer Screening;Characteristics;Child;Chronic;Client;Clinic;Clinical;clinical center;Clinical Research;cohort;Collaborations;comorbidity;Continuity of Patient Care;Country;Data;data quality;Data Sources;Databases;Decentralization;Depressed mood;design;Development;Diabetes Mellitus;Diagnosis;Disease;Ensure;Epidemic;Epidemiology;epidemiology study;Event;experience;Exposure to;female sex worker;follow-up;food insecurity;Fostering;France;Funding;Ghana;Goals;Guidelines;Health;Health Services Accessibility;HIV;HIV Infections;HIV Seropositivity;HIV-1;HIV-2;HIV/AIDS;Housing;Human immunodeficiency virus test;Human Papillomavirus;Human Resources;Hyperlipidemia;Hypertension;Immune;improved;Individual;Infant;Information Systems;International;interpersonal therapy;Intervention;Ivory Coast;Knowledge;Life Expectancy;Mali;Malignant Neoplasms;Measures;meetings;men who have sex with men;Mental Depression;Mental Health;Mission;Morbidity - disease rate;National Institute of Allergy and Infectious Disease;Nigeria;Nigerian;non-alcoholic fatty liver disease;Nongovernmental Organizations;Nutrition Disorders;Outcome;Persons;Population;population based;Positioning Attribute;pre-exposure prophylaxis;Prevalence;Preventive therapy;Procedures;Prognosis;programs;prospective;Prospective cohort;Quality of life;Recommendation;Recovery;reproductive;Research;Research Infrastructure;Resources;scale up;screening;Senegal;Sentinel;service programs;Site;Standardization;Substance Use Disorder;Testing;Thermal Ablation Therapy;Togo;Training;Treatment outcome;trend;Tuberculosis;Tuberculosis diagnosis;Universities;Update;uptake;Viral;Viral Load result;Vulnerable Populations;Woman

PROJECT_TITLE: International Epidemiology Databases to EvaluateAIDS (IeDEA) Renewal 4


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE The goal of this renewal application is to train a diverse cohort of researchers to investigate the etiology and pathophysiology of Alzheimer's Disease and Related Dementias at the University of Pittsburgh. We request support for three (3) pre-doctoral students (pre-doc), and for two (2) post-doctoral fellows (post-docs), for up to 3 years.

PI_NAMEs: ROSANO, CATERINA  (contact);ROSSO, ANDREA L

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TITLE: Population Neuroscience of Aging and Alzheimer's Disease (PNA)


PI_NAMEs: POWERS CARSON, JENNIFER LYNN (contact)

PROJECT_TERMS: adiponectin;Animal Model;Biological Assay;Blood;blood glucose regulation;blood lipid;C-Peptide;Center for Translational Science Activities;Chemistry;Clinical;Clinical Laboratory Improvement Amendments;Clinical Research;clinical translation;Consultations;Contracts;cost;cost effective;Custom;data quality;Development;Diabetes autoantibodies;Diabetes Mellitus;Diagnostic Services;Equipment;Funding;Glucagon;glycosylated serum albumin;Goals;Health;high standard;Hormones;Human;Immunoassay;improved;Institution;instrument;instrumentation;Insulin;Insulin-Dependent Diabetes Mellitus;Interleukin-6;Laboratories;Laboratory Research;Leptin;member;Metabolic;Metabolic Diseases;Metabolism;method development;Methods;Mus;operation;Paper;Plasma;Prevention;Price;programs;Publications;Research;Research Personnel;Sampling;Serum;Services;Signaling Molecule;single molecule;Site;Technical Expertise;Test Result;Testing;testing services;Training;translational diagnostics;Translations;Universities;Urine;Washington

PROJECT_TITLE: Translational Diagnostics


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Complementary and Integrative Health;Emerging Infectious Diseases;Infectious Diseases;Natural Products

ORG_CITY: CARSON

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIV-DOMINGUEZ HILLS

PHR: Project Narrative Fungi are a rich source of structurally diverse secondary metabolites with a wide range of biological applications. This research will explore a large library of fungal metabolites and identify the chemical scaffolds that exhibit bactericidal or antivirulence activity towards antibiotic-resistant pathogenic bacteria that the World Health Organization has deemed the greatest threat to human health.

PI_NAMEs: MCCAULEY, ERIN PATRICIA (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Antibiotic Resistance;Antibiotics;Area;Bacteria;bactericide;Bar Codes;bioactive natural products;Bioinformatics;Biological;Biological Assay;Biomedical Research;California;Cell Wall;Cells;Chemicals;Collaborations;combat;commensal bacteria;data acquisition;Databases;Development;Disease;drug development;drug discovery;Exhibits;Foundations;Fungal natural products;fungus;Future;Genes;Goals;Growth;Habitats;Health;Hispanic-serving Institution;Host Defense;Human;innovation;Libraries;Mammals;marine natural product;Methods;microbial;Microbial natural product;Modern Medicine;Natural Products;Needles;novel;Organism;pathogen;pathogenic bacteria;Phylogenetic Analysis;Phylogeny;Play;priority pathogen;programs;Proteins;Publishing;Recovery;Research;Resistance;Role;Sampling;scaffold;screening;secondary metabolite;small molecule;Source;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Students;Taxonomy;Techniques;Therapeutic;therapeutic development;Time;Traditional Medicine;Type III Secretion System Pathway;Universities;Virulence;Virulence Factors;World Health Organization

PROJECT_TITLE: Discovery of Novel Antibiotic Natural Products from Marine-Derived Fungi


NIH_SPENDING_CATS: Infectious Diseases;Microbiome

PROJECT_TERMS: Acceleration;Affect;algorithm development;animal facility;Animal Model;Animals;Area;Award;bacterial genome sequencing;Base Sequence;Biological;Biological Sciences;Biology;Body Composition;Boston;Breeding;Capital;Clinical;Clinical Trials;Computer Analysis;Computing Methodologies;Containment;Core Facility;cost;density;Development;Diagnostic tests;Digestive System Disorders;Disease;Emerging Technologies;Epithelium;Equipment;Experimental Designs;experimental study;Family suidae;Fermentation;Funding;Future;Germ-Free;Gnotobiotic;Grant;Health;Helicobacter;host microbiome;host microbiota;Human;In Vitro;in vivo;in vivo Model;Individual;Institution;Intake;Interest Group;Investments;Laboratories;Legal patent;Libraries;Logistics;Maintenance;Massachusetts;member;Metabolic;metabolic abnormality assessment;Metabolism;Metagenomics;metatranscriptomics;Microbe;microbial;microbial community;microbial products;Microbiology;microbiome;microbiota;Mission;Molecular;Mus;Names;new technology;novel;operation;outcome prediction;pathogen;Phenotype;Physiological;Physiology;Preparation;Process;Production;Productivity;programs;Publications;Research;Research Personnel;Resources;Role;rRNA Genes;Sampling;Services;Specific qualifier value;square foot;Sterility;Structure;System;Technology;Therapeutic;Training;Work

PROJECT_TITLE: Gnotobiotics, Microbiology and Metagenomics Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Genetics;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Pathogenic bacteria escape from immune defenses, vaccine protection, and antibiotic therapy by rapid changes in global gene composition through horizontal gene transfer. This study will develop tools to observe, for the first time, the complete process of horizontal gene transfer in the major human pathogen, Streptococcus pneumoniae.

PI_NAMEs: EDDINGTON, DAVID  (contact);MORRISON, DONALD

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Affect;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;aqueous;Bacteria;bactericide;Base Pairing;Cell Communication;Cell Separation;cell transformation;Cells;Cessation of life;Clinical;combat;Complex;Cytolysis;Dangerousness;Development;Devices;Diameter;Disease;DNA;Effectiveness;Event;Failure;flexibility;Gene Exchanges;Gene Transfer;Generations;Genes;Genetic;Genetic Recombination;Genetic Transformation;Genome;genome sequencing;genome-wide;Genomic Segment;Genomics;Gram-Positive Bacteria;Horizontal Gene Transfer;human pathogen;Immune;In Vitro;Individual;Infection;Intervention;Laboratories;Lytic;Maps;Measures;Mediating;Medical;Meningitis;meter;Microbial Biofilms;Microfluidic Microchips;Microfluidics;model organism;Modeling;Molecular;Names;novel therapeutics;Nucleotides;Participant;pathogen;pathogenic bacteria;Pathogenicity;Patients;Pattern;Peptides;Pneumonia;Population;Process;Property;prophylactic;Reporting;resistance gene;resistant strain;Resolution;Sepsis;Serotyping;Streptococcus;Streptococcus pneumoniae;success;System;Time;tool;uptake;Vaccination;vaccine formulation;Vaccines;Virulence Factors;Visual;Visualization;whole genome;Work

PROJECT_TITLE: Macrorecombination in isolated cell pairs via natural genetic transformation

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Clinical Research;Diabetes

PI_NAMEs: PISTON, DAVID W (contact)

PROJECT_TERMS: Award;Basic Science;Budgets;career development;Career Mobility;Clinical Sciences;Collaborations;Data;design;Development;Diabetes Mellitus;Extramural Activities;Faculty;Foundations;Funding;Goals;Grant;high risk;Image;innovation;Institution;interest;Investigation;Investments;Mentors;Metabolism;Productivity;programs;Publications;Research;Research Peer Review;Research Personnel;Research Project Grants;Research Support;Resources;success;Translational Research;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: Pilot and Feasibility


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Arthritis;Assistive Technology;Bioengineering;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative Decline in mobility is a critical issue in aging that leads to a less active lifestyle, loss of functional independ- ence, morbidity, and death. The research aims to improve mobility in the senior population with or without mus- culoskeletal diseases using robotic orthoses and neuromechanical computer simulations. The work will also contribute to fundamental knowledge about motor control and rehabilitation regarding human locomotion.

PI_NAMEs: SONG, SEUNGMOON  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: active lifestyle;Adult;Advisory Committees;Affect;age related decline;Aging;Ankle;Behavior;Biomechanics;Cessation of life;Clinical;computer cluster;Computer Simulation;Computer software;Consumption;Data;Development;Energy consumption;Engineering;Environment;environmental change;Evaluation;exoskeleton;experience;experimental study;Fall prevention;falls;functional independence;functional loss;Future;Gait;Gait abnormality;Gerontology;Goals;Human;human subject;improved;improved mobility;innovation;Intervention;Joints;Knee Osteoarthritis;Knowledge;Laboratories;Literature;Locomotion;Measures;Mechanics;member;Mentors;Metabolic;metabolic rate;Mobility decline;Modeling;models and simulation;Morbidity - disease rate;Motion;motor control;motor rehabilitation;Movement;multidisciplinary;Muscle;Musculoskeletal;Musculoskeletal Diseases;Neurologic Gait Disorders;Neuromechanics;neuromusculoskeletal;older adult;open source;Operative Surgical Procedures;Orthotic Devices;Outcome;outcome prediction;Pain;pain reduction;Pathology;Patients;Performance;Phase;Physical activity;Physiology;Population;powered exoskeleton;Process;rehabilitation engineering;Research;Research Personnel;Robotics;Science;Self-Help Devices;simulation;Speed;Testing;Torque;Training;Trauma;United States National Institutes of Health;Universities;Validation;Walking;walking speed;Work;young adult

PROJECT_TITLE: Simulation framework to develop ankle exoskeleton gait assistance for older adults


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Acute severe stress plays a pivotal role in shaping mental health, predisposing individuals to an array of debilitating conditions including post-traumatic stress disorder and anxiety disorders. Here, we investigate how the anterior hypothalamic nucleus (AHN) – a brain region that has previously received little attention – modulates the negative valence of severe stress.

PI_NAMEs: CAI, DENISE JADE (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Acute;Amygdaloid structure;Animals;anterior hypothalamic nucleus;Anxiety;Anxiety Disorders;anxiety-like behavior;Area;Attention;attentional modulation;Aversive Stimulus;Behavior;behavior test;Biological;Brain;Brain region;cell type;Control Animal;Data;design;Disease;Event;experience;Exposure to;Fright;Glutamates;Hippocampus;Image;Immediate-Early Genes;in vivo calcium imaging;Individual;Intervention;Long-Term Effects;Maps;Medial;Mediating;Memory;Mental Health;Mus;Names;Negative Valence;Neurons;novel;optogenetics;Pharmacologic Substance;Play;Post-Traumatic Stress Disorders;Prefrontal Cortex;Process;Regulation;Research;response;Role;Shapes;Site;Stress;Stressful Event;stressor;Testing;Variant;Work

PROJECT_TITLE: Fear and anxiety circuit mechanisms in anterior hypothalamic nucleus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-W(03)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: RELEVANCE The approach and experiments described in this proposal have the potential to produce results that will shed light on the relationships and molecular mechanisms linking changes in metabolism and chromatin structure to Alzheimer’s Diseases. Understanding these relationships will lead to the development of interventions that can ameliorate some of the deleterious consequences of aging and delay the onset and progression of Alzheimer’s Disease.

PI_NAMEs: HELFAND, STEPHEN L (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Affect;age related changes;age related decline;Aging;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease model;Brain;Chromatin;Chromatin Structure;Circadian Rhythms;Dementia;Dinitrophenols;Drosophila genus;effective therapy;experimental study;extend lifespan;fly;frailty;gene therapy;Genetic;Genetic Models;Genome Stability;geroprotector;Geroscience;Goals;Health;healthspan;Histologic;Human;improved;inhibitor;Intervention;Lamivudine;life span;Link;Mammals;Measures;Metabolism;Methyl Ethers;Microscopic;mitochondrial metabolism;Molecular;Molecular Genetics;mouse model;Mus;Mutation;Nerve Degeneration;neurobehavioral;neurobehavioral test;Neurons;neuropathology;novel;Pathway interactions;Persons;pharmacologic;Phenotype;Physiological;resilience;response;Retina;Series;tau Proteins;Testing;therapy development;tool;Transgenes;Translating;United States

PROJECT_TITLE: The effect of life span modifying interventions on Alzheimer's Disease in Drosophila and Mice.


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases

PI_NAMEs: SNAPPER, SCOTT B (contact)

PROJECT_TERMS: Basic Science;biobank;Biology;Biometry;Biopsy;Blood;Blood Cells;Categories;Clinical;clinical application;clinical center;clinical practice;Clinical Research;clinically relevant;Collaborations;Collection;Communication;Data Analyses;data registry;Dedications;design;Digestive System Disorders;Disease;Doctor of Philosophy;Epithelium;Experimental Designs;faculty mentor;falls;Feces;forging;Fostering;Future;gastrointestinal;Gastrointestinal tract structure;Goals;Grant;Guidelines;Health;Human;Human Resources;improved;Inflammatory Bowel Diseases;Infrastructure;Institution;Intestines;Investments;Laboratories;Laboratory Research;Laboratory Study;member;Metadata;Mission;Mucous Membrane;Patient Care;Patients;Productivity;programs;Publications;Research;Research Design;Research Personnel;Resources;Sampling;Services;statistical service;statistics;Tissue Banks;Tissues;Translational Research;translational research program;translational scientist;Translations

PROJECT_TITLE: Clinical Component


PI_NAMEs: SEMENKOVICH, CLAY F. (contact)

PROJECT_TERMS: Address;Award;base;Clinical;Communities;Data;Development;Diabetes Mellitus;experience;Funding;Goals;Grant;Growth;Institution;International;Investigation;Kentucky;Lead;Leadership;Measures;Mentorship;Metabolic Diseases;Metabolism;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Outcome;Pilot Projects;Play;Procedures;programs;Publications;Research;Research Peer Review;Research Personnel;Research Support;Role;Scientist;success;United States National Institutes of Health;Universities;Utah;Washington;Wisconsin

PROJECT_TITLE: Expanded Pilot and Feasability


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Neurofibromatosis type 1 is a common monogenetic disorder, which produces symptoms ranging from tumors to cognitive impairment. This project will examine how Nf1 affects central control of metabolism in an animal model of neurofibromatosis type 1. Results will help develop novel strategies for treatment of the disorder.

PI_NAMEs: TOMCHIK, SETH M (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Adult;Affect;Animal Model;Automobile Driving;Behavioral;cancer predisposition;Cell Physiology;cell type;Cellular Metabolic Process;Childhood;Chronic;clinically relevant;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Development;Diabetes Mellitus;Diet;Disease;Drosophila genus;Energy Metabolism;experimental study;feeding;Foundations;FRAP1 gene;Functional disorder;Future;G-Protein-Coupled Receptors;gain of function;gene conservation;Genes;Genetic;Genetic Diseases;Genomics;Growth;Impaired cognition;in vivo;Individual;inhibitor;insight;Intake;knock-down;Knowledge;Life Expectancy;Link;loss of function;Mediating;MEKs;Messenger RNA;Metabolic;Metabolic Control;metabolic phenotype;metabolic rate;Metabolism;Modeling;Molecular;mutant;Mutation;Nature;Nervous System;neurochemistry;neurofibroma;Neurofibromatosis 1;neuron loss;neuronal circuitry;Neurons;Neurotransmitters;NF1 gene;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Nutrient;optogenetics;Organism;overexpression;Pathway interactions;Patients;Peptides;Peripheral;Pharmaceutical Preparations;Phenocopy;Physiology;PIK3CG gene;Plexiform Neurofibroma;Proteins;ras GTPase-Activating Proteins;rational design;Receptor Activation;Regulation;Research;Rest;RNA Interference;Signal Pathway;Signal Transduction;sugar;Symptoms;Testing;Therapeutic;Time;Tissues;transcriptome sequencing;Transgenic Organisms;treatment strategy;tumor

PROJECT_TITLE: Genetic and molecular mechanisms of Nf1-dependent neuronal regulation of metabolism

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Digestive Diseases

PI_NAMEs: TURNER, JERROLD R. (contact)

PROJECT_TERMS: Award;base;Biology;Biotechnology;career;Conflict of Interest;Decision Making;Development;Digestive System Disorders;Epithelium;Funding;Future;Gastrointestinal tract structure;Grant;innovation;Institution;Leadership;Measures;member;Mission;Outcome;Pilot Projects;Process;programs;recruit;Research;Research Personnel;Role;success;Testing;Training

PROJECT_TITLE: P and F Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE Alzheimer's disease is sixth leading cause of death in the USA and has an enormous social and economic impact that is growing as the population ages. Current treatments are aimed at symptoms and fail to halt the disease. Here we propose a new approach where we chemically target normal aging processes to prevent the disease.

PI_NAMEs: LITHGOW, GORDON J (contact)

PROJECT_TERMS: Age;age related;Aging;aging process;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid beta-Protein;analog;Automobile Driving;Behavioral;Biochemical;Caenorhabditis elegans;Cause of Death;Cell model;Cells;Cessation of life;Chemicals;Chronic;Chronic Disease;Clinical Trials;Cognitive deficits;Data;Defect;Dementia;Disease;economic impact;Effectiveness;effectiveness testing;efficacy evaluation;efficacy testing;extend lifespan;Extracellular Protein;Genetic;Geroscience;Human;human induced pluripotent stem cells;human old age (65+);In Vitro;Induced pluripotent stem cell derived neurons;Intervention;Lead;life span;Mass Spectrum Analysis;Methods;mimetics;Modeling;mouse model;Nematoda;Nerve Degeneration;Nervous System Disorder;Neurofibrillary Tangles;Neurons;neuropathology;neurotoxic;neurotoxicity;normal aging;novel strategies;novel therapeutics;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;Population;premature;prevent;Process;Progressive Disease;Property;protein aggregation;Proteins;proteostasis;proteotoxicity;Publishing;Research;Resources;Social Impacts;Symptoms;tau expression;tau Proteins;Techniques;Testing;Therapeutic;Toxic effect

PROJECT_TITLE: Targeting Aging to prevent Alzheimer's Disease: the Geroscience Approach


NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Aging is the strongest risk factor for nearly all common chronic diseases, and scientists have now identified both shared and unique biochemical pathways across organs and cell types that are altered with age. However, it is unknown if rejuvenation of tissues with young blood can reverse these age-related changes, or rather induces nascent beneficial programs. Here we propose to identify molecular “rejuvenation” signatures across disparate organs and cells with the goal to uncover novel therapeutic targets to slow aging processes and increase healthspan.

PI_NAMEs: WYSS-CORAY, TONY  (contact)

PROGRAM_OFFICER_NAME: WANG, FEI

PROJECT_TERMS: Adipose tissue;Affect;Age;age effect;age related;age related changes;age-related disease;aged;Aging;aging gene;aging mechanism;aging process;Animal Model;Atlases;Biochemical;Biochemical Pathway;Biological Aging;Blood;Body System;bone repair;Brain;Cardiovascular system;Cause of Death;cell type;Cells;Cessation of life;Chronic Disease;Circulation;Cognition;Data;Data Set;Dementia;Diabetes Mellitus;Disease;Disparate;Endothelial Cells;Exhibits;experience;Exposure to;functional improvement;Future;Gene Expression;Gene Expression Profile;Generations;Genetic Transcription;Goals;hallmarks of aging;Health;healthspan;Heart Diseases;Hepatocyte;Human;human old age (65+);improved;Individual;Inflammation;Injections;life span;Liver;Malignant Neoplasms;Mediating;Mediator;Mesentery;Methodology;Methods;mitochondrial dysfunction;Modeling;Molecular;Molecular Profiling;Mus;muscle strength;new therapeutic target;normal aging;novel;novel therapeutics;old mice;Ontology;Operative Surgical Procedures;Organ;Organism;Parabiosis;Pathway interactions;Pattern;Phenotype;Plasma;prevent;pro-aging;Process;programs;Proteins;proteostasis loss;Quality of life;rational design;Rejuvenation;Research;Resistance;response;Risk Factors;Sampling;Scientist;single-cell RNA sequencing;small molecule;System;targeted treatment;temporal measurement;Testing;Therapeutic;Tissues;trafficking;transcriptome;transcriptome sequencing;transcriptomics;Vascular Endothelial Cell;Wild Type Mouse

PROJECT_TITLE: Molecular signature of parabiosis


PI_NAMEs: KAGAN, JONATHAN C (contact)

PROJECT_TERMS: Area;Awareness;Biology;Boston;career;career development;Clinical;Collaborations;Communication;Communities;Development;Digestive System Disorders;Disease;Educational workshop;Epithelium;Event;forging;Fostering;frontier;Functional disorder;Gastrointestinal tract structure;Goals;Grant;gut microbiome;Health;Host Defense;Immunology;interest;Journals;Knowledge;Leadership;Literature;member;Mentors;Mission;Mucous Membrane;multidisciplinary;New England;Patient Care;Process;Productivity;programs;Public Speaking;Research;Research Personnel;Rotation;Scientist;Series;Social Interaction;Source;Special Event;symposium;Talents;Time;Training;translational scientist;Work;Writing

PROJECT_TITLE: Enrichment Program


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Aging;Genetics

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative (2-3 sentences) Loss of telomere protection is the proximal cause of several life-threatening inherited aging disorders and plays a major role in the etiology of cancer, a disease correlated with aging. This project aims to reveal the molecular basis of telomere function with the long-term goal to gain deeper insight into how diminished telomere protection contributes to human age-related diseases.

PI_NAMEs: DE LANGE, TITIA  (contact)

PROJECT_TERMS: Affect;age-related disease;Aging;aging related disease;ATM Signaling Pathway;Binding;Biochemical;Biological;Biology;bone marrow failure syndrome;BRCA2 gene;Cancer Etiology;Cells;Cellular biology;Chromatin Loop;Chromosomes;Complement;Complex;Data;Defect;Disease;DNA;DNA Binding;DNA Damage;DNA replication fork;DNA-Binding Proteins;Elements;Event;Experimental Designs;experimental study;Functional disorder;Generations;Genetic;Goals;helicase;Human;human disease;in vivo;Inherited;Inherited bone marrow failure;innovation;insight;Invaded;Life;life span;Maintenance;Malignant Neoplasms;Mediating;Modeling;Molecular;Molecular Genetics;Nature;Nonhomologous DNA End Joining;novel;Play;prevent;Process;Proliferating;Protein Complex Subunit;protein protein interaction;Proteomics;Rad51 recombinase;Reaction;Repression;response;Role;Sister;Structure;telomere;telomere loss;Telomere Maintenance;TERF1 gene;Testing;TINF2 gene;tool

PROJECT_TITLE: Mechanism of the telomeric proliferation limit

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Lung;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Idiopathic pulmonary fibrosis remains a major cause of morbidity and mortality worldwide, and available therapies are limited in their efficacy. Fibrotic scar arises due to disordered or ineffective repair after injury, however we do not understand why some lungs scar after injury and some lungs heal normally. This project seeks to better understand the mechanisms of lung repair in response to injury to develop more effective therapies.

PI_NAMEs: TING, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Affect;Alveolar;alveolar epithelium;Antibodies;Antioxidants;Award;Biological Assay;Bleomycin;Cell Aging;Cell Culture Techniques;Cell Cycle Arrest;Cell Death;Cell Physiology;cell type;Cells;Cellular Stress;Cicatrix;Clinical Management;Communication;Data;Defect;Development;differential expression;Disease;effective therapy;Epithelial Cells;epithelial repair;Epithelium;Exhibits;experience;experimental study;Extracellular Matrix Proteins;Failure;Fibroblasts;Fibrosis;fibrotic lung;fibrotic lung disease;gain of function;Genes;genetic approach;Genetic Transcription;healing;Human;human induced pluripotent stem cells;idiopathic pulmonary fibrosis;In Vitro;in vitro Model;in vivo;in vivo evaluation;in vivo Model;indium-bleomycin;Inflammatory;Injury;Interstitial Lung Diseases;knock-down;Knowledge;Liver;loss of function;Lung;lung injury;lung repair;Lung Transplantation;Mediating;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Natural regeneration;novel therapeutic intervention;Pathogenesis;Patients;Physicians;Physiological;Plasma;Process;promoter;Proteins;Pulmonary Fibrosis;Reactive Oxygen Species;Recombinants;Regulation;repaired;Research;Research Training;respiratory;response;response to injury;RNA Interference;Role;Scientist;Seminal;senescence;Signal Transduction;skills;Skin;Small Interfering RNA;Source;stem cell proliferation;stem cells;Stimulus;Supportive care;Technical Expertise;TGF Beta Signaling Pathway;TGFB1 gene;tissue fixing;Tissues;Training;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Transitional Cell;Transitional Epithelium;Transplantation;wound healing

PROJECT_TITLE: Regulation and Mechanisms of Transitional Epithelial Cell Senescence in Lung Fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: MIAMI

ORG_NAME: INTELLIGENT HEARING SYSTEMS

PHR: As of 2019, more than 736,900 patients have received cochlear implants (CI) worldwide. It is important to assess the functional status of the cochlea and 8th nerve prior to implant surgery. The development of an integrated eeABR acquisition system with the proposed artifact cancellation, stimulation and signal processing techniques is expected to greatly improve the quality of eeABR recordings and make the technique more widely available. As such, the proposed work will greatly impact public health by developing better objective 8th nerve assessment techniques prior to CI surgery.

PI_NAMEs: DELGADO, RAFAEL E (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Address;Amplifiers;Anatomy;Animal Experiments;Audiology;Auditory Brainstem Responses;Auditory Perception;Benefits and Risks;Caregivers;Cell Nucleus;Clinical;Clinical Trials;Cochlea;Cochlear implant procedure;Cochlear Implants;cochlear lesion;Cochlear Nerve;Computer software;computerized data processing;Cranial Nerves;data acquisition;design;Development;Device Designs;Devices;Ear;Economics;Effectiveness;Electric Stimulation;Electrodes;Evoked Potentials;functional status;Hearing;human subject;Implant;implantable device;implantation;improved;innovation;Magnetic Resonance Imaging;Manufacturer;Measurement;Measures;Michigan;Modeling;Modification;Morphologic artifacts;Nerve;Noise;novel;Operative Surgical Procedures;Outcome;Pathologic;Pathology;Patients;Performance;Phase;Physicians;portability;Postoperative Period;prognostication;Promontory;prototype;Public Health;Qualifying;Rattus norvegicus;Recovery;Research;Residual state;response;Response to stimulus physiology;Risk;signal processing;Signal Transduction;somatosensory;Stimulus;stimulus processing;System;Techniques;Telemetry;Testing;Time;tool;United States Food and Drug Administration;Work

PROJECT_TITLE: Device for assessment of 8th nerve function and cochlear implant candidacy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-M (12)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome;Prevention

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Candida auris is an emerging fungal pathogen with high transmission rates within healthcare facilities, and high mortality rates associated with bloodstream infections. This project will investigate the genetic mechanisms facilitating the ability of C. auris to colonize skin, which serves as a source for transmission between patients as well as the reservoir for deadly bloodstream infections. Uncovering these mechanisms can help to identify key vulnerabilities in this emerging fungal pathogen for therapeutic intervention and prevention of colonization and disease.

PI_NAMEs: ZHAO, GUOLEI  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Adherence;Adhesions;Agglutinins;Amino Acid Sequence;Animal Model;anti-fungal agents;Bacterial Adhesins;Biology;Candida albicans;Candida auris;Cell surface;Cell Wall;Characteristics;Chromatin Remodeling Factor;Clinical;Complement;Data;Death Rate;Development;Disease;Disease Outbreaks;Ensure;Epithelial Cells;Epithelium;Exhibits;experience;experimental study;Family;forward genetics;functional genomics;Future;Genes;Genetic;genetic approach;Genetic Epistasis;Genetic Screening;Genetic Transcription;Genome;Goals;Health care facility;Heterogeneity;Homologous Gene;Hospitals;host colonization;Image;In Vitro;in vivo;Individual;Infection;insight;Invaded;Investigation;keratinocyte;Life;Mediating;member;Microscopy;Modeling;Molecular;Molecular Biology;Molecular Genetics;mouse model;Mus;mutant;Mutation;New York;novel;Nucleosomes;outbreak concern;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;Patients;Population;Positioning Attribute;Predisposition;prevent;Prevention;promoter;Protein Family;Proteins;Public Health;receptor;Regulation;Research;reverse genetics;Risk;Risk Factors;Role;Sepsis;Skin;Skin colonization;Source;SWI/SNF Family Complex;targeted treatment;Testing;Therapeutic Intervention;Tissues;tool;trait;Transcriptional Regulation;translational impact;transmission process;Vaccines;Virulence;Virulence Factors;Work

PROJECT_TITLE: Genetic circuitry governing skin colonization of Candida auris

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-S (20)]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: UNION

ORG_NAME: KATHERA BIOSCIENCE INC.

ORG_STATE: NJ

PHR: Project Narrative The World Health Organization (WHO) released a report in October 2022 highlighting the increasing worldwide threat of invasive fungal infections, including drug-resistant infections, especially among expanding populations of immunocompromised individuals (https://www.who.int/publications/i/item/9789240060241). Its goals were to direct attention to the growing problem of fungal diseases, to galvanize support for public health measures, to promote research and development (R&D) in this area, and to support development of new therapies to treat fungal infections. This proposal is a collaborative effort between industry experts with decades of experience in antimicrobial drug R&D and university scientists that aims to develop novel inhibitors of fungal DHFR, an essential fungal target with a unique mode of action, into new, broad-spectrum drugs to tackle the problem of emerging and drug-resistant fungal infections.

PI_NAMEs: PARENT, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Achievement;Address;Amino Acids;analog;antagonist;Anti-Bacterial Agents;anti-fungal agents;anti-microbial drug;Antiparasitic Agents;Area;Arthrodermataceae;Aspergillus;Bacteria;Biochemical;Biological Assay;Biological Sciences;Candida;Candida albicans;candidate identification;Candidiasis;cell growth;Cell Survival;Cell Wall;Cells;Cellular Assay;Clinical;clinical diagnosis;Clinical Trials;computational chemistry;Cryptococcus;Dependence;design;Development;dihydrofolate;Dihydrofolate Reductase;Dihydrofolate Reductase Inhibitor;directed attention;Disease;Dose;drug candidate;drug development;Drug Interactions;Drug resistance;drug synthesis;Drug Targeting;emerging pathogen;Enzyme Inhibition;Enzymes;Eukaryota;experience;first-in-human;Food;fungus;Genetic;Goals;Growth;Human;Immunocompromised Host;Immunology;improved;In Vitro;in vivo;in vivo Model;Individual;Industry;Infection;inhibitor;intravenous administration;Investigational Drugs;Kidney;Lead;lead candidate;lead optimization;lead series;Life;Mammalian Cell;Measures;Membrane;Modeling;Molds;Mucorales;Mus;Mycoses;novel;novel therapeutics;Oncology;Oral;Outcome;Paracoccidioides;pathogenic fungus;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacology;Phase;Phase I Clinical Trials;Phase II Clinical Trials;Pneumocystis carinii;Population;Predisposition;programs;Public Health;Publications;Purines;Reporting;Research;research and development;Resistance;Resources;Safety;Scientist;Series;Serum;Source;Structure;Study models;Synthesis Chemistry;Testing;Tetrahydrofolates;Therapeutic;Thymidine Monophosphate;Toxic effect;Trimethoprim-Sulfamethoxazole;Universities;Validation;validation studies;Work;World Health Organization

PROJECT_TITLE: Novel Broad Spectrum Inhibitors of Dihydrofolate Reductase (DHFR) for Treatment of Infections from High Threat Fungal Pathogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (12)]


NIH_SPENDING_CATS: Cancer;Interstitial Cystitis;Kidney Disease;Prevention;Radiation Oncology;Urologic Diseases

ORG_CITY: ROYAL OAK

ORG_NAME: WILLIAM BEAUMONT HOSPITAL RESEARCH INST

PHR: NARRATIVE Radiation cystitis is a severely debilitating chronic fibrotic bladder condition that results from radiation therapy for cancers in the pelvis for which no safe and effective treatment exists to date. Amphiregulin is a pro-fibrotic protein that is highly expressed in the bladder after radiation therapy and thus we hypothesize that amphiregulin mediates radiation-induced bladder fibrosis and can serve as a predictive marker for radiation cystitis. The successful outcomes of this study will determine if amphiregulin is a viable therapeutic target for radiation-induced fibrosis which will also be relevant for other benign bladder conditions characterized by a fibrotic bladder.

PI_NAMEs: ZWAANS, BERNADETTE MARGARETHA MARIA (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Age;age acceleration;Amphiregulin;Animal Model;Applications Grants;Award;Benign;Binding;Biological Assay;Biological Markers;Bladder;Bladder Urothelium;Blood coagulation;Blood Vessels;Body System;cancer radiation therapy;cancer survival;Cancer Survivor;Cancer Survivorship;cancer therapy;Cell Aging;Cell Line;cell type;Characteristics;Chronic;Chronic Kidney Failure;Collection;Colorectal Cancer;conventional therapy;detrusor muscle;Doctor of Philosophy;Early Diagnosis;effective therapy;Environment;Epidermal Growth Factor;Epidermal Growth Factor Receptor;Epithelial Cells;experience;falls;Family;Fibrosis;Health;Heart;Hematuria;Hour;Human;improved;In Vitro;in vivo;Increased frequency of micturition;Injury;Injury to Kidney;innovation;irradiation;Kidney;kidney fibrosis;Knock-out;Knowledge;Life;Liver;Lung;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;Medical;member;Microscopic;Mission;Modeling;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;Newly Diagnosed;Outcome;Outcome Study;overexpression;Pain;Pathologic;Patients;Pattern;Pelvic Cancer;Pelvic Pain;Pelvis;Phase;Phenotype;Pilot Projects;Population;pre-clinical;Pre-Clinical Model;predictive marker;prevent;Price;Process;Productivity;Profibrotic signal;Proteins;Proteomics;Quality of life;quality of life for cancer survivors;Radiation;radiation cystitis;Radiation Fibrosis;Radiation Injuries;Radiation therapy;Research;Research Institute;response;Risk;Risk Factors;Role;Sampling;senescent cell;Severities;side effect;Skin;survivorship;Symptoms;Testing;therapeutic target;Time;tissue injury;tissue regeneration;Tissues;tool;Training;United States;UPK2 gene;urinary;Urination;Urine;Urothelial Cell;Urothelium

PROJECT_TITLE: The role of amphiregulin in mediating radiation cystitis in cancer survivors

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Complementary and Integrative Health;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SIOUX FALLS

ORG_NAME: OMEGAQUANT ANALYTICS, LLC

ORG_STATE: SD

PHR: Project Narrative Early identification of patients at risk for memory loss or Alzheimer’s disease related dementias (ADRD) are urgently needed so that preventive measures can be instituted early. We propose to develop and validate a blood fatty acid profile to identify disordered fatty acid patterns predictive of the development of ADRD or memory loss, using existing data from four well-respected US cohort studies. Our ultimate goal is to market a blood fatty acid profile which, either alone or in combination with other risk factors, improves the prediction of impending memory loss and/or ADRD.

PI_NAMEs: HARRIS, BILL  (contact)

PROGRAM_OFFICER_NAME: RADOJA, NADEZDA

PROJECT_TERMS: adjudication;Age;Algorithms;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Amyloid beta-Protein;apolipoprotein E-4;base;Behavior;Behavior Therapy;Biological Markers;Biometry;Black Populations;Blood;Boston;burden of illness;Businesses;Caregivers;Caring;Clinical;Cognition;Cognitive;Cohort Studies;Collection;Data;data access;data harmonization;Dementia;dementia risk;Development;Diagnosis;Dietary Fatty Acid;Disease;Disease Progression;Dryness;Early identification;Economic Burden;Erythrocytes;Ethnic Origin;Ethnic Population;executive function;family caregiving;Family member;Fatty Acids;follow-up;Framingham Heart Study;Friends;Goals;Health;Healthcare;high risk;high risk population;Hispanic Populations;Home;Homocysteine;human old age (65+);Impaired cognition;improved;indexing;Individual;innovation;interest;Intervention;Laboratories;Life Style;Machine Learning;machine learning algorithm;Marketing;Measurement;Measures;Medical;Memory;Memory Loss;Modeling;Neuropsychology;Omega-3 Fatty Acids;Other Genetics;Pathway interactions;Patients;Pattern;payment;Phase;Plasma;predictive marker;Prevalence;prevent;Preventive measure;Price;Probability;prognostic indicator;Prospective cohort;Prospective Studies;Prospective, cohort study;Proteins;Puerto Rican;Race;racial population;randomized, clinical trials;Reporting;Research Institute;Research Personnel;Risk;Risk Factors;Sample Size;Sampling;Senile Plaques;sex;Signal Transduction;Social Network;socioeconomics;Spottings;statistical and machine learning;Subgroup;System;tau Proteins;Testing;Time;Vitamin D;willingness to pay;Women's Health

PROJECT_TITLE: Developing a blood fatty acid-based algorithm as an early predictor of cognitive decline and dementia: Applying machine learning to harmonized data from prospective cohort studies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-G (13)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAN DIEGO

ORG_NAME: 3DT HOLDINGS, LLC

PHR: NARRATIVE Mitra-Clip (MC) is an emerging technology to reduce mitral regurgitation in patients with mitral valve dysfunction. The goal of this Fast-Track proposal is to provide a software tool to aid the clinician in the surgical planning of the MC for improved patient safety and outcome.

PI_NAMEs: GUCCIONE, JULIUS MATTEO (contact);KASSAB, GHASSAN S

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;Animal Experimentation;Animal Model;Animals;Area;Artificial Intelligence;artificial intelligence model;Attenuated;Automation;Award;Blood Vessels;Cardiac;cardiac device;Cardiac Surgery procedures;Catheterization;Clinic;Clinical;Clinical Data;clinically relevant;Clip;comorbidity;Complex;Computer software;Data;Data Set;Databases;Decision Making;Devices;Digital Imaging and Communications in Medicine;Documentation;Effectiveness;Elements;Emerging Technologies;Evaluation;experience;experimental study;Family suidae;frailty;Functional disorder;Geometry;Goals;good laboratory practice;Heart Atrium;heart function;Heart Valve Diseases;Image;image processing;improved;in silico;Intervention;Laboratories;Left;Left ventricular structure;Location;Machine Learning;machine learning algorithm;machine learning model;machine learning prediction;Manuals;mathematical model;Measures;Mechanics;Medicine;Methods;Mitral Valve;Mitral Valve Insufficiency;model development;Modeling;Myocardial;Operative Surgical Procedures;Outcome;Output;Patient imaging;patient safety;Patient Selection;Patient-Focused Outcomes;Patients;Performance;Phase;Physics;Population;Preparation;pressure;Probability;Procedures;Process;Publications;Research;Safety;Shapes;simulation;Site;software as a medical device;Software Tools;Software Validation;Stress;Structure;success;Surveys;Test Result;therapy outcome;Time;time use;Transesophageal Echocardiography;Translating;Validation;verification and validation

PROJECT_TITLE: Software-guided Operative Planning of MitraClip Placement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (14)]


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Services;Lung

ORG_CITY: PHILADELPHIA

ORG_NAME: PHRASE HEALTH, INC.

PHR: Project Narrative Clinical decision support (CDS) has the potential to improve patient outcomes by facilitating adherence to evidence-based practices, but it is burdensome to monitor and is oftentimes ineffective as a result. Phrase Health created Outcomes, a process evaluation web-based product to diagnose when and why CDS is not leading to the intended improvements. We are developing an “out of the box” library of quality improvement (QI) project templates for the Outcomes product that are based on asthma, bronchiolitis, and chronic obstructive pulmonary disease (COPD) best practice guidelines.

PI_NAMEs: TOBIAS, MARC  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: 12 year old;Acceleration;Address;Adherence;Adoption;Advocate;Agreement;Architecture;Asthma;Bronchiolitis;Chronic;Chronic Obstructive Pulmonary Disease;Clinical;clinical application;clinical care;clinical decision support;Clinical Practice Guideline;Clinical Trials;cognitive load;cohort;commercialization;cost;Data;Data Sources;Diagnosis;Disease;effective intervention;Emergency Situation;Engineering;Environment;evidence base;Evidence based practice;experience;Feedback;Financial cost;Future;graphical user interface;Guidelines;Health;health empowerment;Health system;Hospitals;improved;improved outcome;Incentives;insight;Intervention;Interview;Investments;Knowledge;Knowledge Discovery;knowledge translation;Libraries;Lung Diseases;Maps;Marketing;Measures;Meta-Analysis;Methods;Mission;Modeling;Monitor;Mus;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel;Online Systems;Outcome;Patient Care;Patient-Focused Outcomes;Patients;payment;Phase;phrases;Population;Practice Guidelines;Process;process evaluation;Provider;Recommendation;research clinical testing;Sales;Services;Sickle Cell Anemia;Site;Structure;support tools;Surveys;System;Time;tool;Traction;Translating;usability;Variant;Walking

PROJECT_TITLE: Developing an "Out of the Box" Quality Improvement Library for Lung Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-J (10)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Immunotherapy;Lung;Women's Health Research

ORG_CITY: North Andover

ORG_NAME: EMBIOSYS INC.

PHR: PROJECT NARRATIVE Metastasis or spread is the foremost cause of cancer-related deaths. We have developed a wearable, non-pharmacological approach to non-invasively apply induced electric fields (iEFs) and shown in a mouse model, that aggressive breast tumors and their metastasis to the lungs can be reduced significantly. In this work, we are establishing the safety of iEF therapy as a standalone treatment for aggressive breast cancer and assessing efficacy of combining iEF therapy with currently used chemotherapies with the aim of improving effectiveness and patient tolerance of current standard of care.

PI_NAMEs: SUBRAMANIAM, VISH V. (contact)

PROGRAM_OFFICER_NAME: ZANE, LINDA KARINE

PROJECT_TERMS: Adjuvant Chemotherapy;Adjuvant Therapy;Adverse effects;Affect;aggressive breast cancer;anti-cancer;Biological;Biological Assay;Biological Markers;Blood;Breast Cancer Model;Breast Cancer Patient;cancer cell;Cancer Etiology;capecitabine;Cells;Cessation of life;chemotherapeutic agent;chemotherapy;Clinic;Clinical;Combined Modality Therapy;commercialization;Complement;Cytoskeleton;cytotoxic;Cytotoxic T-Lymphocytes;Data;Development;Devices;Diagnosis;Disease;Distant;Distant Metastasis;Dose;Effectiveness;efficacy evaluation;electric field;Electromagnetic Fields;Eligibility Determination;F-Actin;Filopodia;Foundations;Frequencies;Goals;Human;Immune;Immune response;Immune system;Immuno-Chemotherapy;Immunocompetent;Immunooncology;Immunotherapy;improved;In Vitro;in vivo;Infiltration;Ionizing radiation;Lung;Macrophage;Malignant Breast Neoplasm;Mammary Neoplasms;Medical Device;Metabolic Pathway;Metastatic Neoplasm to the Lung;Microtus;migration;Mitochondria;Morbidity - disease rate;Motility;mouse model;Mus;Neoadjuvant Therapy;Neoplasm Metastasis;Nonpharmacologic Therapy;novel;Ohio;Operative Surgical Procedures;Organ;Oxidative Phosphorylation;Paclitaxel;patient population;patient tolerability;Patient-derived xenograft models of breast cancer;Patients;pembrolizumab;Phase;polymerization;Polymers;Population;Positioning Attribute;pre-clinical;prevent;Primary Neoplasm;Prognosis;programmed cell death ligand 1;prototype;Qualifying;Radiation therapy;Reagent;Recurrence;Relapse;response;response biomarker;Safety;standard care;standard of care;Survival Rate;Technology;Testing;therapeutically effective;Tissues;Translations;triple-negative invasive breast carcinoma;tumor;Tumor Burden;tumor growth;tumor metabolism;tumor microenvironment;Tumor Volume;Tumor-associated macrophages;tumorigenic;Universities;Visceral;voltage;wearable device;Work

PROJECT_TITLE: DEVELOPMENT OF A WEARABLE, NON-INVASIVE, TREATMENT DEVICE FOR METASTATIC TRIPLE-NEGATIVE BREAST CANCER (TNBC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-V (13)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse;Women's Health Research

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative The goal of this proposal is to support the training of a promising young scientific researcher, allowing her to improve her skills in experimental design and techniques, scientific communication, and professional development. Through this proposal, the applicant will design and carry out experiments analyzing the underlying neurobiology of cue-driven psychopathologies, resulting in scientific publications that will serve as a foundation for her career in academia.

PI_NAMEs: CZESAK, FRANKIE NICOLE (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Academia;addiction;Affect;Animal Housing;Animal Model;Animals;approach behavior;Association Learning;Attenuated;aversive conditioning;Behavior;behavior test;Behavioral;biological sex;career;Communication;comorbidity;Computer software;conditioned fear;conditioning;Cues;Data;design;designer receptors exclusively activated by designer drugs;Desire for food;Development;Disease;Doctor of Philosophy;Dopamine;dual diagnosis;Emotional;Environment;equity, diversity, and inclusion;Exhibits;experience;Experimental Designs;experimental study;Female;Fiber;Food;foot;Foundations;Fright;Genetic;genetic approach;Glutamates;Goals;graduate student;Hippocampus;Histology;Implant;improved;in vivo;Incubated;Individual Differences;individualized medicine;Knowledge;Learning;Lesion;Location;Machine Learning;male;Measures;Memory impairment;Mental disorders;Mentors;Methods;Michigan;Microscopy;Mission;Motivation;National Institute of Drug Abuse;neural;neural circuit;Neural Pathways;Neurobiology;Neurons;Neurosciences;Nucleus Accumbens;optical fiber;Pathway interactions;Phenotype;Photometry;Play;Population;Post-Traumatic Stress Disorders;Predisposition;Process;Program Development;programs;psychiatric comorbidity;Psychiatry;Psychopathology;public health priorities;Publications;Publishing;Rattus;receptor;Research;Research Personnel;Research Project Grants;Resources;response;Rewards;Role;Science;Scientist;selective expression;sex;Sex Differences;Shock;skills;Stress;success;Surgical Equipment;Techniques;Testing;Time;Training;Training Programs;Training Support;undergraduate research;United States National Institutes of Health;Universities;Variant;vector;Ventral Tegmental Area;Viral;Virginia;Work

PROJECT_TITLE: Determining the contribution of pathway-specific neural activity to individual and sex differences in the attribution of salience to emotional cues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Many advanced, metastatic cancers are particularly hard to treat and possess features of chromosomal instability, or the inability to properly separate chromosomes during mitosis. Preliminary data from our laboratory demonstrate that these metastatic cancers disproportionally rely on a gene, NDE1, for growth and survival. Here, we investigate the mechanism behind NDE1 dependence and explore the therapeutic benefit of targeting NDE1 in cancers with chromosomal instability.

PI_NAMEs: BRIDGWATER, CAROLINE MARIE (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: 17p;Aneuploidy;Area;arm;Binding;Biology;cancer cell;Cancer cell line;Candidate Disease Gene;Cell Line;Cell model;Cells;Centrosome;Characteristics;Chromosomal Instability;Chromosomal Loss;Chromosomal Stability;Chromosome 17;chromosome 17p loss;chromosome missegregation;Chromosome Segregation;Chromosomes;CRISPR screen;Data;Databases;Defect;Dependence;Disseminated Malignant Neoplasm;Engineering;Ensure;Essential Genes;Exhibits;functional loss;gamma Tubulin;Genes;Genetic;genomic profiling;Genomics;Growth;Human;In Vitro;in vivo;interest;International;Karyotype determination procedure;Knock-out;Laboratories;live cell imaging;Loss of Heterozygosity;Malignant Neoplasms;Microtubules;Mitosis;Mitotic;Modeling;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel therapeutics;paralogous gene;refractory cancer;Reporting;Role;Sampling;segregation;Testing;The Cancer Genome Atlas;Therapeutic;TP53 gene;tumor;Tumor Suppressor Genes;validation studies;whole genome;Work

PROJECT_TITLE: Chromosomal Instability and 17p Loss Sensitize Cancer Cells to NDE1 Depletion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Genetics

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Heterochromatin is a conserved feature of eukaryotic chromosomes with roles in the regulation of gene expression and maintenance of genome stability, and contributes to normal development and disease progression in humans. A basic understanding of the mechanisms that mediate the assembly and epigenetic inheritance of heterochromatin will not only provide a framework for understanding how the epigenetic regulatory mechanisms can fail, but also provides the substrate and knowledge to design therapeutic strategies based on intervention.

PI_NAMEs: SOTOMAYOR, ROBERTO G (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Affinity;Binding;Biochemical;Biochemistry;cancer therapy;Cell Differentiation process;Cells;Chromatin;chromatin remodeling;Chromosomes;Complex;Data;Defect;design;Development;Disease;Disease Progression;DNA;DNA Binding;DNA Transposable Elements;Epigenetic Process;Euchromatin;Exclusion;experimental study;Fission Yeast;fly;Gene Expression Regulation;gene repression;Gene Silencing;Genetic;Genetic Transcription;Genome Stability;Heterochromatin;heterochromatin-specific nonhistone chromosomal protein HP-1;Histone Deacetylase;histone methylation;Histones;Homologous Gene;Human;Impairment;insight;Intervention;Knowledge;Link;Liquid substance;Lysine;Maintenance;Mediating;Methods;Methyltransferase;Modeling;Modification;Monitor;Mus;mutant;Mutation;Nuclear;Nucleosomes;Pathway interactions;Phase;Play;Polymerase;preservation;Process;promoter;Protein Family;Proteins;Proteome;Proteomics;recruit;Repression;RNA;RNA Decay;RNA Polymerase II;Role;TATA-Box Binding Protein;Testing;Therapeutic;therapy development;tool;Transcript;transcription factor;Transcription Initiation;Work

PROJECT_TITLE: Mechanisms of Heterochromatic Transcriptional Gene Silencing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ORG_CITY: GLOUCESTER

ORG_NAME: SENSIMETRICS CORPORATION

PHR: Project Narrative / Public Health Relevance This project aims to develop earphones free of metallic components for use in next-generation ultra-high- field MRI scanners, overcoming shortcomings of current models. This will support basic and clinical research on auditory brain mechanisms at greater spatial and temporal imaging resolution than currently possible. Such research is fundamentally important in the effort to advance brain science and, more specifically, to help understand central disorders relating to speech and hearing.

PI_NAMEs: VON WIEGAND, THOMAS EDWARD (contact)

PROJECT_TERMS: 3-Dimensional;Acoustics;Amplifiers;Anatomy;Animal Experimentation;attenuation;Auditory;Auditory Perception;auditory stimulus;Basic Science;Brain;carbon fiber;Characteristics;Choking;Clinical Research;Closure by clamp;Copper;Custom;Deposition;design;Dimensions;Disease;Elasticity;elastomeric;Elastomers;Elements;Evaluation;Exclusion;Exhibits;External auditory canal;Fiber;Foundations;France;Frequencies;Future Generations;Generations;Goals;Government;Head;Hearing;Heating;high resolution imaging;Human;Image;improved;Injections;innovation;Laboratories;Length;magnetic field;Magnetic Resonance Imaging;Magnetism;Manufacturer;Marketing;Measures;Mechanics;metallicity;Metals;Modeling;Molds;Morphologic artifacts;Natural graphite;next generation;Noise;novel;novel strategies;operation;Output;Pair Bond;Performance;Persons;Phase;Physics;Predisposition;pressure;prevent;Process;Protocols documentation;prototype;public health relevance;Publishing;radio frequency;Research;research and development;research study;Resolution;response;Risk;Safety;safety assessment;Scanning;Science;Secure;Shapes;sound;Speech;Stimulus;Stress Tests;Structure;success;System;Temperature;Testing;Transducers

PROJECT_TITLE: Non-metallic earbuds for auditory stimuli in MRI scanners

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: PRINCETON

ORG_NAME: RICOVR HEALTHCARE INC.

PHR: Project narrative Maternal morbidity and mortality associated with pre-eclampsia, a pregnancy associated condition, is a serious health crisis within the United States. There is currently a lack of accurate and objective tools for predicting and diagnosing pre-eclampsia, exacerbating the poor conditions for mothers and the healthcare system. Ricovr will apply its novel biosensor technology to develop an affordable point-of-care test to aid in pre-eclampsia diagnosis.

PI_NAMEs: SEIMETZ, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Affect;Antibodies;antibody detection;assay development;Binding;Biological;Biological Assay;Biological Markers;Biometry;Biosensor;Blood Pressure;Clinical;clinical application;clinical diagnostics;Clinical Trials;clinically relevant;commercialization;cost;density;Detection;detection assay;detection limit;detection platform;detector;Development;Devices;Diagnosis;Diagnostic;diagnostic assay;diagnostic platform;Diagnostic tests;diagnostic value;Diameter;Disease;Disparity;Drug usage;Early Diagnosis;early screening;Early treatment;Enzyme-Linked Immunosorbent Assay;experience;Fiber Optics;Glass;Glycolipids;Growth and Development function;Gynecologist;Health;Health Personnel;Healthcare;Healthcare Systems;Hypertension;Immunoassay;Incidence;Incubated;interest;invention;Knowledge;Legal patent;Literature;Maternal Health Services;maternal morbidity;Maternal Mortality;Measurable;Measurement;Measures;Monitor;Morbidity - disease rate;mortality;Mothers;nanoGold;nanoparticle;novel;novel diagnostics;Optics;Patients;Performance;PGF gene;Phase;Placentation;Plasma;plasmonics;Play;point of care;point of care testing;point-of-care diagnostics;Positioning Attribute;Pre-Eclampsia;predictive marker;predictive tools;Predictive Value;Pregnancy;pregnancy disorder;pregnancy hypertension;Prenatal care;Prevalence;Primary Care;Proteins;Race;Reader;Recording of previous events;Research;Resource-limited setting;risk stratification;Saliva;salivary assay;Sampling;screening;Sensitivity and Specificity;Serum;Small Business Innovation Research Grant;small molecule;Socioeconomic Factors;Socioeconomic Status;standard of care;Surface Plasmon Resonance;Symptoms;technological innovation;Technology;technology platform;temporal measurement;Testing;tool;Tuberculosis diagnosis;United States;urinary;Urine;Validation;Visit;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Quantitative measurement of PlGF using a rapid, low-cost, point-of-care (POC) diagnostic platform for prediction and detection of pre-eclampsia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (10)]


NIH_SPENDING_CATS: Digestive Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Intestinal health relies on an intact single layer of barrier cells that originate from a progenitor population of intestinal stem cells. How these stem cells sense environmental cues in order to make adjustments during infection and damage to maintain a healthy intestinal barrier is poorly understood. This proposal will establish a fundamental mechanism where intestinal stem cells take up dead neighboring cells to regulate their growth, turnover and differentiation, thereby establishing a new for therapeutic discovery in a variety of inflammatory intestinal diseases.

PI_NAMEs: ZHOU, JULIE  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Address;Apoptotic;Applications Grants;Automobile Driving;base;biobank;Biological;Biology;Cell Culture Techniques;Cell Death;Cell Differentiation process;cell type;Cells;Columnar Cell;Cues;Cultured Cells;Data;Disease;Environment;Epithelial Cells;epithelial injury;Epithelium;Future;Genetic Models;Growth;Health;Homeostasis;Host Defense;Human;improved;In Vitro;in vivo;in vivo Model;Infection;Inflammatory Bowel Diseases;Ingestion;Injury;injury and repair;intestinal barrier;intestinal epithelium;intestinal injury;Intestines;Knowledge;Laboratories;LGR5 gene;Lysosomes;Macrophage;Mediating;Microscopy;Modality;Modeling;Modernization;mouse genetics;mouse model;Mus;novel therapeutics;Opsonin;Organ;Phagocytosis;pharmacologic;Physiologic pulse;Polymers;Population;preservation;Process;Production;programs;Proliferating;regenerative;regenerative growth;repaired;Research;response;response to injury;restoration;Sampling;Secretory Cell;Seminal;Signal Transduction;Site;spheroids;stem;stem cell biology;stem cell function;stem cell growth;stem cell population;stem cell proliferation;stem cells;Structure of intestinal gland;Techniques;Testing;therapeutic target;Tissues;tool;Transforming Growth Factor beta;Up-Regulation;uptake;Work

PROJECT_TITLE: Internalization of dead cells governs intestinal stem cell activity

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (O4)]


NIH_SPENDING_CATS: Chronic Pain;Neurosciences;Pain Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE Over 50 million Americans suffer from debilitating chronic pain; given that most of these patients do not have effective treatment options there is an urgent clinical need to understand the neurobiological mechanisms underlying the emergence of chronic pain to facilitate the development of novel therapeutics. This project is designed to uncover how astrocytes, critical modulators of synapse development and function, contribute to the persistent amplification of nociceptive signal transmission in pathological conditions. A better understanding of how glial cells contribute to persistent pain would aid in advancing chronic pain prevention and management strategies by identifying novel non-neuronal therapeutic targets.

PI_NAMEs: YOO, JUDY JOONHI (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acids;Admission activity;Adult;Afferent Neurons;American;Astrocytes;Attenuated;Brain;Calcium Signaling;Caring;Cartoons;Chemosensitization;Child;chordin;chronic pain;chronic pain management;Clinical;Communication;design;Development;dorsal horn;effective therapy;Electrophysiology (science);Environment;experience;Fostering;Foundations;Genetic;genetic approach;Glutamate Receptor;Glypican;Goals;In Vitro;Injury;innovation;insight;Knowledge;Life;Literature;Long-Term Effects;Long-Term Potentiation;Measures;Mediating;Mediator;Medical;Molecular;Neonatal;neonatal injury;Neonatal Intensive Care Units;neonatal surgery;neurobiological mechanism;Neuroglia;Neurons;new therapeutic target;Nociception;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Pain;pain perception;pain signal;patch clamp;Pathologic;Pathway interactions;Patients;Permeability;permissiveness;Persistent pain;postsynaptic;presynaptic;Prevention;Property;Reaction;receptor expression;recruit;Regulation;Relaxation;Reporting;Research;response;Role;Sensory;Signal Transduction;Spinal;Spinal Cord;Spine pain;Stimulus;Surgical incisions;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;Therapeutic;therapeutic target;Tissues;transmission process;United States;Work

PROJECT_TITLE: Astrocytes mediate priming of spinal nociceptive circuits

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Retrotransposonable elements (RTEs) which are genomic elements that have the ability to replicate and insert themselves into new genomic locations through RNA intermediates, are largely silenced in most cell types, but are active during neurodevelopment. Overly active RTEs have been correlated with a number of neurodevelopmental disorders, but discrete mechanistic roles remain elusive. This proposal aims to understand whether RTE activity regulates neurodevelopment, the mechanisms by which overactive RTEs can cause diseases, and whether inhibiting RTE activity can prevent neurodevelopmental disorders such as microcephaly.

PI_NAMEs: TALLEY, MARY  (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Adult;Apoptosis;Attention deficit hyperactivity disorder;autism spectrum disorder;Automobile Driving;Behavior;Biological Assay;Brain;brain size;Cell Aging;Cell Count;Cell Death;cell type;Cells;Central Nervous System;Cerebrum;comorbidity;condensin;Data;Development;Disease;DNA Damage;DNA Probes;Drosophila genome;Drosophila genus;Elements;experience;Future;Genes;Genome;Genomic Instability;genomic locus;Genomics;Head;Human;Human Genome;induced pluripotent stem cell;Lead;Life;Location;loss of function mutation;Mediating;Microcephaly;Modeling;Molecular;Mutation;neural;neurodevelopment;Neurodevelopmental Disorder;neuroregulation;Nucleosides;Organoids;Outcome Study;overexpression;Paste substance;Pathway interactions;Patients;Play;preclinical study;prevent;Repression;Research;response;Rett Syndrome;Reverse Transcriptase Inhibitors;RNA;RNA Interference;Role;single-cell RNA sequencing;stem;stem cells;System;Testing;Therapeutic

PROJECT_TITLE: The role of retrotransposonable elements in neurodevelopment and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: ANDOVER

ORG_NAME: PHYSICAL SCIENCES, INC

PHR: Project Narrative  Disruptions of the complicated neuron signaling network underlie a variety of neurological disorders including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, among others. This proposed, first-of-its-kind, head-mounted voltage imager will provide neuroscientists with the capability of studying the detailed dynamics of neuronal activity in the brain of freely-behaving animals, which in turn, will support the understanding of disease mechanisms and development of new therapeutics.

PI_NAMEs: YOO, HYEJIN  (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: Action Potentials;Acute;Algorithms;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Animal Model;Animals;awake;Axon;Behavior;Behavioral;Brain;brain behavior;Brain imaging;Brain region;Calibration;Cells;Cellular Stress;cognitive function;Collaborations;Complex;confocal imaging;Dendrites;design;Detection;detection method;detector;Development;Discrimination;Disease;Electrophysiology (science);Event;experimental study;Fiber;Fluorescence;fluorescence imaging;Generations;Goals;Head;Hippocampus;Hybrids;Image;image processing;imager;imaging approach;imaging capabilities;imaging probe;imaging system;Imaging technology;improved;In Vitro;in vivo;in vivo imaging;in vivo Model;Individual;Investigation;Kinetics;Label;Lateral;lens;Lighting;Maps;Measurement;Measures;Membrane;Membrane Potentials;meter;Methods;Microscope;Microscopy;Microspheres;millisecond;miniaturize;Modification;Mus;Nervous System Disorder;neural;neuroimaging;Neurologic Dysfunctions;neuronal excitability;Neurons;Neurosciences;Neurosciences Research;neurotransmission;novel;novel therapeutics;Optics;Parkinson Disease;patch clamp;Pattern;Performance;Phase;physical science;Population;postsynaptic;programs;Proteins;Reporter;research and development;Resolution;Rodent;Sampling;Scanning;Scientist;sensor;signal processing;Signal Transduction;Slice;spatiotemporal;Speed;Structure;submicron;success;Synapses;Synaptic Potentials;System;technological innovation;Technology;temporal measurement;Testing;Thinness;Time;tool;Transfection;Transgenic Mice;Tube;voltage;Work

PROJECT_TITLE: Head-mounted, high-speed confocal imager for voltage-sensitive neuronal recording


ORG_CITY: CHICAGO

ORG_NAME: IMMUNEBRO THERAPEUTICS INC.

PHR: Project Narrative Immunebro Therapeutics is developing a simple and novel approach to produce donor-derived off-the-shelf (OTS) cancer-targeting T cells. OTS T cell products developed from this platform are anticipated to significantly improve the survival and life quality of a variety of cancer patients with immediate availability, safety, potency, and affordability.

PI_NAMEs: LI, GONGBO  (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: Allogenic;Antigens;Autologous;bi-specific T cell engager;Cancer Patient;cancer therapy;CAR T cell therapy;carcinogenesis;CD19 gene;CD3 Antigens;CD80 gene;cell killing;Cell Therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;clinical application;comparative efficacy;Complex;cost;cytokine;Data;design;Detection;Development;disease model;disorder risk;DNA Sequence;Dose;drug candidate;engineered T cells;Engineering;enhancing factor;Enzyme-Linked Immunosorbent Assay;Failure;Flow Cytometry;Future;Genes;Goals;graft versus host disease induction;graft vs host disease;Hematopoietic Neoplasms;Immune;immunodeficiency;Implant;improved;Inferior;Interleukin-15;Knock-out;leukemia;Leukemic Cell;Malignant Neoplasms;manufacture;manufacturing process;Marketing;Modeling;Monitor;mouse model;Mus;Names;Natural Killer Cells;novel;novel strategies;Patients;PF4 Gene;Phase;Price;Proteins;prototype;Quality of life;Recombinants;Regulation;Retroviral Vector;Retroviridae;Risk;Safety;Side;Small Business Innovation Research Grant;success;Surface;Symptoms;T cell therapy;T-Cell Receptor;T-Lymphocyte;technology platform;Therapeutic;Time;Tissues;tool;transgene expression;Tumor Suppression;Weight;Work;Xenograft procedure

PROJECT_TITLE: Engager T cell: A Simple Solution for Off-the-shelf T Cell Therapy for Cancer


NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: More than 3 million Americans have impaired walking due to a stroke, in spite of receiving conventional treatment. This proposal aims to improve the design of a muscle interface device and test whether it can improve walking function in people with stroke.

PI_NAMEs: DHAHER, YASIN YOUSEF;SLUTZKY, MARC W. (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Adherence;Affect;American;arm;arm movement;Biofeedback;Central Nervous System;Chronic;chronic stroke;Clinical;clinical practice;clinical translation;Clinical Trials;Clip;conditioning;Continuity of Patient Care;conventional therapy;Corticospinal Tracts;Coupling;Data;design;Development;Devices;dosage;Dose;Electrodes;empowerment;Ensure;Extensor;Feedback;flexibility;flexible electronics;functional improvement;Gait;Gait abnormality;gaming environment;Goals;Hip region structure;Home;Impairment;improved;innovation;Inpatients;Intuition;Joints;kinematics;Knee;laboratory experience;Leg;Location;Locomotor Recovery;Long term disability;Movement;Muscle;neurological rehabilitation;novel;Outcome;Participant;patient engagement;Patients;Persons;post stroke;Quality of life;Randomized;Recovery;Recovery of Function;Reflex action;Rehabilitation therapy;Research;response;sensor;Signal Transduction;Skin;spatiotemporal;Spinal Cord;spinal reflex;Startle Reaction;Stroke;stroke rehabilitation;stroke survivor;synergism;System;Tendon Reflex;Testing;Training;Transcranial magnetic stimulation;Translating;translational potential;user-friendly;Walking;walking speed;wearable device;wireless;Work

PROJECT_TITLE: MINT conditioning to improve post-stroke gait

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Neonatal Respiratory Distress;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: FORT WORTH

ORG_NAME: AYUVIS RESEARCH, INC.

ORG_STATE: TX

PHR: NARRATIVE Bronchopulmunary Dysplasia (BPD) is a disease of pre-term infants whose lungs are injured upon exposure to excess oxygen from ventilators, impairing effective gas exchange in the lungs and AyuVis Research is developing a novel class of immunomodulating small molecule derived from chitin that decrease inflammation, improve lung vascularization, decrease pulmonary hypertension and altogether prevent the depelopment of BPD in preclinical large animal model. Our objective in this proposed grant application is to assess the safety and pharmacokinetic profile of our lead compound in a Phase I SAD/MAD Clinical Trial in healty human volunteers, followed by an exploratory efficacy Phase-2a Trial in preterm infants at-risk of developing BPD. These proposed studies are key stages in the development of our much needed prophylactic treatment for BPD in infants and treatment for other life-threatening lung conditions.

PI_NAMEs: ACHARYA, SUCHISMITA  (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: Adolescent;Adrenal Cortex Hormones;Adult;Affect;Alveolar;Angiogenic Factor;Animal Model;antenatal;Anti-Inflammatory Agents;Applications Grants;Bacteremia;Biological Markers;Blood;Blood specimen;Bolus Infusion;Bronchopulmonary Dysplasia;Canis familiaris;Cardiotoxicity;Cell Death;Cells;Cessation of life;Childhood;Chitin;chronic respiratory disease;Clinical;Clinical Protocols;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;comorbidity;Complication;Consent Forms;Contracts;cooking;Data;Development;Diagnosis;Disease;Dose;drug development;Drug Kinetics;Dysplasia;early childhood;efficacy clinical trial;efficacy evaluation;Endothelial Growth Factors;Exposure to;Future;Gases;Genetic Predisposition to Disease;genotoxicity;Gestational Age;Goals;Gram-Negative Bacterial Infections;Human;Human Volunteers;Hyperoxia;Immunologist;immunoregulation;Impairment;improved;In Vitro;Incidence;Infant;Infection;Inflammation;Inflammation Mediators;Injections;Interleukin-10;Intervention;Intraperitoneal Injections;Intravenous;intravenous administration;intravenous injection;Lead;lead candidate;Life;Lung;Lung Compliance;lung injury;Macrophage;Manuals;Marketing;Maximum Tolerated Dose;Mechanical ventilation;Mechanical Ventilators;meetings;Modeling;Molecular Weight;Mononuclear;mortality;mouse model;Mus;Neonatal;neonatal mice;neonate;No-Observed-Adverse-Effect Level;novel;novel therapeutics;Oligosaccharides;operation;Orphan Drugs;Oxygen;Pathologic;Pathway interactions;Pediatric Hospitals;Pharmaceutical Preparations;pharmacodynamic biomarker;Phase;Phase I Clinical Trials;Phenotype;pre-clinical;pre-Investigational New Drug meeting;Premature Birth;Premature Infant;prenatal;Preparation;preterm newborn;prevent;Procedures;product development;Production;programs;Prophylactic treatment;Protocols documentation;pulmonary function;Pulmonary Hypertension;Pulmonary Inflammation;pup;Rattus;Recommendation;recruit;Reporting;Research;Research Contracts;Research Personnel;respiratory;Respiratory Disease;Respiratory physiology;Risk;Safety;safety assessment;Sample Size;Scientist;Seasons;Secondary to;Serum;Signal Transduction;Small Business Innovation Research Grant;small molecule;Spleen;surfactant;Techniques;Texas;Therapeutic Effect;Therapeutic Index;Time;timeline;TLR4 gene;Transforming Growth Factor beta;Up-Regulation;Vascular Endothelial Growth Factors;Vascularization;ventilation;Ventilator;volunteer;Writing

PROJECT_TITLE: Phase 1 Safety, Pharmacokinetic study followed by Phase 2a Proof-of-Concept study of AVR-48, a small molecule macrophage modulator to prevent bronchopulmonary dysplasia in neonates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (11)]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Physical Activity;Prevention;Rehabilitation;Women's Health Research

PHR: Project Narrative Cancer-related fatigue (CRF) is the most common and distressing long-term side effect of breast cancer disease and treatment. Physical activity is the first-line treatment recommended to reduce fatigue levels in breast cancer survivors, but no scalable, tailored physical activity intervention designed to meet the specific needs of breast cancer survivors with CRF exist. The public health significance of this study lies in its potential to better understand how to promote physical activity in BCS with CRF to inform future intervention development and, ultimately, improve health outcomes and quality of life in this large and growing population.

PI_NAMEs: SOLK, PAYTON  (contact)

PROJECT_TERMS: Administrator;Adoption;Advanced Practice Nurse;Aerobic Exercise;Aftercare;Behavior Therapy;Breast Cancer survivor;Breast Cancer survivorship;cancer care;cancer diagnosis;Cancer Survivor;Characteristics;Clinical;community partners;Continuity of Patient Care;Custom;Data;Data Analyses;design;Development;Disease;Distress;Effectiveness of Interventions;Engineering;Evaluation;evidence base;Exercise;exercise intervention;experience;experimental study;Fatigue;Fellowship;fitbit;flexibility;Foundations;Funding;Future;Goals;Guidelines;Health;Health Promotion;improved;Individual;innovation;insight;Intervention;intervention delivery;intervention effect;Interview;Light;Malignant Breast Neoplasm;Malignant Neoplasms;Methodology;mHealth;mhealth interventions;mobile application;moderate-to-vigorous physical activity;multiphase optimization strategy;Needs Assessment;Oncologist;Oncology;Outcome;Participant;Patients;Personal Satisfaction;pharmacologic;Pharmacological Treatment;Phase;Physical activity;Physical Function;Population;preference;Preparation;Prevalence;programs;Psychologist;Public Health;Quality of life;Questionnaires;Recommendation;Recurrence;Research;Sampling;sedentary lifestyle;side effect;Site;social cognitive theory;Specialist;Structure;Subgroup;survivorship;symptom management;Symptoms;tailored text messaging;Testing;Text Messaging;therapy design;therapy development;tool;Training;training opportunity;Translating;Treatment-Related Cancer;United States;uptake;Well in self;Woman;Work

PROJECT_TITLE: Examining Physical Activity Promotion Intervention Outcomes, Barriers and Facilitators in Breast Cancer Survivors with Fatigue

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]