NIH_SPENDING_CATS: Natural Products

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative  Plant terpenoids like cyclopamine (anti-cancer) can exhibit remarkable medicinal properties, however, the production of terpenoids via plant biosynthesis or chemical synthesis remains challenging. In contrast, engineered microorganisms can be used for the scalable, renewable, and inexpensive production of individual terpenoids like artemisinin (anti-malaria) from simple sugars and salts. This proposal aims to engineer brewer’s yeast (Saccharomyces cerevisiae) to solve the challenge of sourcing cyclopamine for cancer treatment, establish methods to rapidly produce diverse libraries of triterpenoids as potential drug candidates, and accelerate the future microbial biosynthesis of medicinal terpenoids.

PI_NAMEs: WINEGAR, PETER HENRY (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Acceleration;Acids;Anabolism;analog;anti-cancer;Anti-malarials;Antineoplastic Agents;Artemisinins;California;cancer clinical trial;cancer therapy;chemical synthesis;Chemicals;Cholesterol;clinical development;Clinical Treatment;Clinical Trials;combinatorial;Combined Modality Therapy;Complex;cost;Cyclization;cyclopamine;Disease;drug candidate;drug production;Engineering;Environmental Impact;Enzymes;Exhibits;FDA approved;Future;Genes;glycosylation;glycosyltransferase;Immune system;Individual;inhibitor;Learning;Libraries;Lilium;Logic;Malaria;Medicine;Methods;microbial;microorganism;Natural Products;Nature;novel therapeutics;oxidation;Oxidation-Reduction;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Plants;Production;Property;reduce symptoms;Research;Saccharomyces cerevisiae;Salts;scaffold;screening;smoothened signaling pathway;Source;sugar;Terpenes;Terpenoid Biosynthesis Pathway;Time;Transaminases;Veratrum;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Biosynthesis of Cyclopamine and New-to-Nature Triterpenoids in Yeast

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Infertility;Maternal Health;Pregnancy;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The research on factors that contribute to safe reproductive health outcomes remains limited, as demonstrated by the alarming increase in maternal mortality rates. This project aims to investigate the differentiation pathway of uterine natural killer (uNK) cells from peripheral blood NK (pbNK) cells to decidualized NK (dNK) cells. By understanding the transcriptional program and factors involved in the creation of uNK and dNK cells, the most abundant leukocyte in the endometrium, scientists may identify the causes of pathological reproduction, infertility, and miscarriage, ultimately leading to improved outcomes in maternal and fetal health.

PI_NAMEs: GREENE, MORGAN ELIZABETH-CAROLYN (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Age;aged;Applications Grants;Area;Automobile Driving;Bioinformatics;Biological Assay;Biopsy;Blood;Blood Cells;career;Cell Differentiation process;cell type;Cells;Censuses;Centers for Disease Control and Prevention (U.S.);Circulation;Classification;Clinical;clinical application;Collecting Cell;Communication;Comprehension;Consensus;Critical Thinking;cytokine;cytotoxic;Data;Data Set;Death Rate;Decidua;Decidual Cell;Decidual Cell Reactions;design;Development;Discipline of obstetrics;Embryo Transfer;Endometrial;Endometrium;Environment;Evaluation;Exhibits;experience;Face;FCGR3B gene;Female;fetal;Fetal health;First Pregnancy Trimester;Flow Cytometry;Foundations;Future;Genes;Genetic;Genetic Transcription;Goals;Grant;Growth;Gynecology;Health;Immune;immune reconstitution;Immune system;Immunity;Immunization;Immunology;immunoregulation;improved;improved outcome;In Vitro;Incubated;Individual;Infertility;Intervention;Knowledge;Leukocytes;Lymphocyte;Lymphoid Cell;Maintenance;Major Histocompatibility Complex;Manuscripts;Maternal Health;Maternal Mortality;Membrane Proteins;Menstrual cycle;Mentors;Natural Killer Cells;NCAM1 gene;Organ;Outcome;Outcomes Research;Pathologic;Pathway interactions;peripheral blood;Phase;Phenotype;Physicians;precision medicine;Pregnancy;Pregnancy Complications;Preparation;Prevention;Principal Investigator;Process;Program Development;programs;Property;recruit;Reporting;Reproduction;Reproductive Health;Reproductive Immunology;Reproductive Physiology;Research;Research Project Grants;responsible research conduct;Review Literature;RNA;RNA replication;Role;Sampling;Scientist;single-cell RNA sequencing;skills;Sorting;Spontaneous abortion;success;Techniques;Testing;Tissues;tool;Training;transcriptome;transcriptomics;translational approach;Translational Research;Transplantation;treatment strategy;tumor;United States;United States National Institutes of Health;Uterus;Validation;Virus;Woman;Work;Writing

PROJECT_TITLE: Ontogeny and differentiation of uterine natural killer cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-L (20)]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Hypertension;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative This proposal outlines a training and research plan to investigate the utility of trans-ancestry polygenic risk scores in a real-world, ancestrally diverse cohort to predict health outcomes in a clinical setting. The research is relevant to NHGRI’s bold predictions by 2030, number 6 “The regular use of genomic information will have transitioned from boutique to mainstream in all clinical settings, making genomic testing as routine as complete blood counts” and number 9: “Individuals from ancestrally diverse backgrounds will benefit equitably from advances in human genomics.”

PI_NAMEs: MAVURA, YUSUPH  (contact)

PROGRAM_OFFICER_NAME: HERNANDEZ-RAMON, ELENA ESTELA

PROJECT_TERMS: adverse outcome;Affect;African American population;Alcohol consumption;Anti-Hypertensive Agents;Antigens;Behavioral;biobank;Blood Pressure;Cardiovascular Diseases;career;caucasian American;Clinical;clinical predictors;clinical risk;cohort;Complete Blood Count;Complex;Computing Methodologies;Data;Dementia;Diet;Disease;Electronic Health Record;Environmental Risk Factor;epidemiology study;Equity;ethnic disparity;Ethnic Origin;genetic epidemiology;Genetic Risk;genetic variant;genome wide association study;genome-wide;Genomics;Genotype;Goals;Grant;Health;health disparity;Heart failure;Human Genome;human genomics;Hypertension;improved;Incidence;Individual;Intervention;Japan;Kidney Diseases;Knowledge;Life Cycle Stages;Life Style;Link;Longitudinal cohort;Mainstreaming;Malignant neoplasm of prostate;Mentorship;Methods;Morbidity - disease rate;mortality;multidisciplinary;National Human Genome Research Institute;non-genetic;Outcome;Pharmaceutical Preparations;polygenic risk score;Population;Population Heterogeneity;Postdoctoral Fellow;Prevention;programs;Prostate;Race;racial disparity;racial population;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;risk prediction;risk stratification;screening;Serum;sex;skill acquisition;Smoking;Socioeconomic Status;statistics;Stroke;Surveys;Testing;Therapeutic;Time;Training;trait;Underrepresented Populations;Veterans

PROJECT_TITLE: Assessing Clinical Utility of Polygenic Risk Scores in Ancestrally Diverse Real-World Cohorts

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Wound Healing and Care

ORG_CITY: Chicago

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Within healing wounds, many different types of cells work together to repair damaged tissue. This proposal will examine how small extracellular vesicles released by one cell type, endothelial cells, affect the function and behavior of another cell type, fibroblasts, in the context of the healing wound. The results of this study will better inform our fundamental understanding of how cells communicate in wounds, and may lead us to discover new therapies to improve healing or prevent scar formation.

PI_NAMEs: YUAN, HEIDI  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Adipose tissue;Affect;angiogenesis;Architecture;autocrine;Behavior;Binding;Bioinformatics;Biological Assay;career development;Cell Communication;Cell Physiology;Cell secretion;cell type;Cells;Cicatrix;Collagen;Communication;Communication Methods;comparison control;Complex;Data;Deposition;Dermal;Dermis;design;Development;Disease;DNA;Endocrine;Endothelial Cells;Environment;Epidermis;Excision;Exhibits;experimental study;Exposure to;Extracellular Matrix;extracellular vesicles;Fibroblasts;Gene Expression Profile;Gene Targeting;Goals;Granulation Tissue;healing;Hemostatic function;Human;improved;in silico;In Vitro;in vitro Assay;in vivo;Infiltration;Inflammation;Inflammatory;Institution;intercellular communication;Label;laboratory experiment;Lipids;Mediating;Mediator;Membrane;Methods;MicroRNAs;Molecular;Mus;Myofibroblast;novel;novel therapeutics;Nucleic Acids;paracrine;particle;Pathology;Pathway interactions;Phase;Phenotype;Physiological;Population;prevent;Process;Proliferating;Proteins;Quantitative Reverse Transcriptase PCR;re-epithelialization;repaired;Research;Research Personnel;Research Training;Resources;Role;Scleroderma;Signal Transduction;single-cell RNA sequencing;Skin;Skin injury;skin wound;Skin wound healing;Small RNA;Sorting;Specific qualifier value;Splint Device;standard measure;subcutaneous;Systemic Scleroderma;Techniques;Testing;therapeutic target;Thick;Tissues;Training;transcriptome;transcriptome sequencing;transcriptomics;Transfection;Untranslated RNA;uptake;Vascularization;vesicular release;Work;wound;wound closure;wound healing;Wound models;wound treatment

PROJECT_TITLE: Endothelial cell-fibroblast communication in skin wound healing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-C (20)]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: STANFORD

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Chromosomes must accurately segregate in order for organisms to develop and survive. Chromosome segregation errors lead to aneuploidy that drives cancer and genetic disease. Our proposed studies address the mechanisms that ensure proper chromosome segregation to avoid cancer and genetic disease associated aneuploidy.

PI_NAMEs: STRAIGHT, AARON F (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3-Dimensional;Address;Aneuploidy;Binding;Binding Proteins;Binding Sites;Biochemical;Cell Cycle;Cell Death;Cell division;Cell Division Process;Cells;Centromere;centromere protein A;centromere protein C;Chromatin;chromatin protein;chromosome missegregation;chromosome movement;Chromosome Segregation;Chromosomes;citrate carrier;Complement;Complex;Coupling;Defect;density;dimer;DNA;DNA Binding;Down's Syndrome;Ensure;Epigenetic Process;Eukaryota;Genetic Diseases;Genome;Genome Stability;Histone H3;Histones;HMGN Proteins;Human;Human Genetics;Interphase;Kinetochores;Lead;Maintenance;Malignant Neoplasms;Maps;Metaphase;Methods;Methylation;Microtubules;Mitotic Chromosome;Mitotic spindle;Molecular Chaperones;Natural regeneration;Nucleosomes;Organism;Physical condensation;Positioning Attribute;prevent;Property;protein complex;Proteins;recruit;Resistance;Role;segregation;Site;Structure;Testing;Variant;Vertebrates;Work;Xenopus

PROJECT_TITLE: Mechanisms of Kinetochore Assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-D (02)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Breastfeeding, Lactation and Breast Milk;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Maternal Health;Nutrition;Pediatric;Prevention;Vaccine Related;Women's Health Research

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE Human milk provides significant health benefits to infants as well as the lactating parent, and while breastfeeding is recommended for the first six months of life, many families struggle to initiate and maintain lactation. Few clinical interventions exist to improve lactation outcomes, in part due to lack of understanding of the cellular process of lactation by cells in the mammary gland. This study will leverage existing transcriptomic data of mammary gland cells from human milk to identify the gene pathways underlying the process of lactation and its response to disease.

PI_NAMEs: NYQUIST, SARAH KATE (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Age Months;Anabolism;Antibodies;antibody transfer;Area;Biological;Biological Process;Biological Response Modifiers;Biology;Biotechnology;Blood;Blood specimen;Breast Feeding;career;Cell Physiology;Cells;Centers for Disease Control and Prevention (U.S.);Characteristics;Clinical;COVID-19;COVID-19 booster;COVID-19 vaccination;Data;Data Science;Data Set;Disease;Epithelial Cells;Exposure to;Family;FDA approved;Future;Genes;Genetic Transcription;Goals;Health;Health Benefit;human data;Human Milk;human milk oligosaccharides;Immune;Immunity;Immunology;improved;Individual;Infant;Infant Development;Infant Health;infant nutrition;Infection;Institution;Interdisciplinary Study;interest;Intervention;Knowledge;Lactation;Left;Life;Lipids;Liquid substance;Maintenance;mammary;Mammary gland;Maternal Health;Measurement;meetings;Mentors;Metabolic;method development;Methods;Milk;milk production;milk supply;Modeling;mortality;Nature;novel;Nutrient;Nutritional;Outcome;Parents;Pathway interactions;post-doctoral training;Process;Production;programs;Publishing;Recommendation;Research;response;responsible research conduct;Role;Sample Size;Sampling;SARS-CoV-2 infection;Secondary Immunization;single-cell RNA sequencing;Statistical Data Interpretation;Statistical Methods;Statistical Models;Stimulus;Techniques;Time;tool;Training;transcriptomics;Vaccination;Variant;Viral Vaccines;Virus Diseases;Work

PROJECT_TITLE: Transcriptional variation in human milk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE The apoE4 gene is the strongest genetic risk factor for late onset Alzheimer’s disease and is implicated in early prodromal network dysfunction in the dentate gyrus of the hippocampus. Our preliminary work suggests an apoE4-induced accumulation of immature hyperexcitable dentate granule cells in aged mice. The proposed studies will use a combination of electrophysiology with single cell transcriptomics (patchSeq) together with morphological reconstruction to determine the mechanisms underlying apoE4-induced dentate gyrus dysfunction and how these mechanisms may be counteracted and treated.

PI_NAMEs: TABUENA, DENNIS R (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Accounting;Adult;adult neurogenesis;Affect;Age;Age of Onset;aged;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Animals;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;career development;Cell Maturation;Cells;Cellular Morphology;cellular transduction;Characteristics;Classification;combinatorial;Computer Analysis;CRISPR-mediated transcriptional activation;Data;density;dentate gyrus;differential expression;Electrophysiology (science);Equipment;Exhibits;experimental study;Fellowship Program;Functional disorder;Future;Gene Expression Profile;Gene Targeting;Genes;Genetic;genetic manipulation;genetic profiling;genetic risk factor;Genotype;granule cell;Hippocampus;Human;Hyperactivity;Impaired cognition;Incidence;Individual;insight;Investigation;Knock-in;Knock-in Mouse;Late Onset Alzheimer Disease;Learning;Location;Measures;Mediating;Memory;Memory impairment;Methodology;migration;Modification;Morphology;mouse model;multimodality;Mus;Nervous System Disorder;network dysfunction;Neurodegenerative Disorders;neurogenesis;Neurons;non-demented;novel strategies;old mice;Ontology;Outcome;Parahippocampal Gyrus;patch clamp;Pathology;Pattern;Persons;Physiology;Play;Population;Process;prodromal Alzheimer's disease;Protein Isoforms;Publishing;reconstruction;Research;Resolution;Risk;Role;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Synapses;tau Proteins;Technical Expertise;Testing;Therapeutic;therapeutic development;therapeutic gene;Time;Training;transcriptome;transcriptome sequencing;transcriptomics;Vertebral column;Work

PROJECT_TITLE: Investigation into transcriptomic control of dentate granule cell maturation and hyperexcitability in the apoE4 Alzheimer's Disease model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-N (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative The decline of neurogenesis has been associated with many neurological disorders. Considering the critical role NR2E1, a nuclear receptor, plays in regulating neurogenesis, it is likely that certain NR2E1 missense mutations might cause neurogenesis-associated pathology by impairing NR2E1 function and/or activity. Our project will investigate the molecular, cellular, and behavioral consequences of one patient-specific NR2E1 mutation to gain insight into the importance of NR2E1 for human neurogenesis.

PI_NAMEs: LEI, KEVIN  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Adult;adult neurogenesis;Affect;Affinity;Aggressive behavior;Animal Model;Anxiety;Automobile Driving;Behavior;Behavioral;Binding;Biological Assay;Biophysics;Birth;Brain;C-terminal;career;Cell Cycle;Cells;Central Nervous System;clinically relevant;Co-Immunoprecipitations;Code;CRISPR/Cas technology;Data;Databases;Development;Embryo;Endowment;Engineering;Etiology;Foundations;Future;Genes;genetic corepressor;genetic variant;global developmental delay;Glutamates;Hippocampus;Human;human disease;human model;Human Pathology;Immunohistochemistry;Impaired cognition;Impairment;improved;Impulsivity;In Vitro;in vitro Assay;in vivo;Individual;insight;Intellectual functioning disability;interest;Interferometry;Knowledge;Laboratories;Learning;Life;life span;Ligand Binding;Ligand Binding Domain;Ligands;loss of function;maladaptive behavior;member;Memory;Mental Depression;Missense Mutation;Modeling;Molecular;mouse model;Mus;Mutate;Mutation;Neonatal;nerve stem cell;Nervous System Disorder;neural;neuroblast;neurogenesis;Neurologic;Neuronal Differentiation;Neurons;Nuclear Receptors;Oleic Acids;Organoids;overexpression;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Peptides;personalized therapeutic;Phenotype;Play;Process;Property;protein function;Proteins;receptor;recruit;Research;Retina;Role;screening;Single Nucleotide Polymorphism;single-cell RNA sequencing;small molecule;Solid;stem cell biology;stem cell proliferation;stem cell self renewal;Study models;System;targeted treatment;Testing;therapeutic target;Thinness;tool;Training;Transcription Coactivator;Transcription Repressor;transcriptome;transcriptomics;women patients

PROJECT_TITLE: Effects of the NR2E1 mutation on cellular and molecular determinants of neurogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Dietary Supplements;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Microbiome;Nutrition;Pediatric;Prevention;Social Determinants of Health;Vaccine Related

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Rotavirus vaccine was developed to prevent severe diarrhea and is especially important in low- and middle- income countries where 85% of deaths due to rotaviruses occur; unfortunately, vaccine efficacy is lower in these countries compared to high-income countries. This proposal will study infants from three countries with different socioeconomic levels and use sophisticated methods to determine how specific bacteria in the infant gut (microbiome) may change the response to the vaccine. If successful, this study will have a significant impact on this important public health disparity as a targeted intervention to improve vaccine response, even if small, could save tens of thousands of lives every year.

PI_NAMEs: PANNARAJ, PIA S (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: 5 year old;Address;Age Months;Antibodies;Antibody titer measurement;Bacteria;Bifidobacterium;Biochemistry;Bioinformatics;Biological Markers;Birth;Blood;Blood specimen;Cell Differentiation process;cell growth;Cell Proliferation;Cells;Cessation of life;Child;Country;Data;Dehydration;design;Detection;Development;Diarrhea;Disparity;Enrollment;Ensure;Feces;Folic Acid;Folic Acid Deficiency;folic acid supplementation;Genes;gut microbiome;gut microbiota;health disparity;Human;Immune;immune function;Immune response;Immune Targeting;Immunization;immunogenic;Immunoglobulin A;Immunologics;Immunology;immunoregulation;improved;Income;Infant;Infection;Intervention;Intestines;Life;Literature;low and middle-income countries;low income country;Lymphocyte;Maintenance;Mediator;Memory;Metabolic;Metabolic Biotransformation;metabolic profile;Metabolism;metabolomics;metagenomic sequencing;Methods;Microbe;microbial;Microbiology;microbiome;Multiomic Data;Mus;novel;Nutrient;Oral;oral vaccine;Panama;Pathway interactions;Peptides;Peru;Peruvian;Pilot Projects;Population;prevent;preventive intervention;Production;prospective;Public Health;public health priorities;Recommendation;Regulatory T-Lymphocyte;responders and non-responders;response;Role;Rotavirus;Rotavirus Infections;Rotavirus Vaccines;sample collection;Sample Size;Sampling;Serum;Shotguns;socioeconomics;Specificity;statistical and machine learning;stool sample;T cell response;T memory cell;T-Cell Proliferation;Therapeutic Intervention;Time;Vaccination;vaccine access;vaccine effectiveness;vaccine efficacy;vaccine immunogenicity;vaccine response;vaccine-induced antibodies;Vaccines;vaccinology;Vitamins

PROJECT_TITLE: Gut microbial and metabolic mediators of rotavirus vaccine response

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Splicing factors (SF) control which version of a given gene is expressed. Defects in SFs lead to human diseases such as neurological disorders, cardiac myopathies, diabetes, lupus, or cancer. Here, we will elucidate at the molecular level how SFs are regulated, and will develop molecules to correct SF defects in disease models.

PI_NAMEs: ANCZUKOW-CAMARDA, OLGA  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affect;Alternative Splicing;Apoptosis;Arginine;Binding;Binding Proteins;Binding Sites;Biological Assay;Cardiac;Cell Differentiation process;Cell Line;Cell model;Cell Physiology;cell type;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;CRISPR library;CRISPR screen;CRISPR/Cas technology;Data;Defect;Development;Diabetes Mellitus;Differentiation Antigens;Disease;disease model;Dose;Embryo;Embryonic Development;Engineering;Epithelium;Eukaryota;Exons;Family;Gene Expression;Gene Proteins;Generations;Genes;genetic regulatory protein;Homeostasis;Human;human disease;Human Pathology;In Vitro;in vivo;Invaded;knock-down;Lead;Lupus;Malignant Neoplasms;Maps;Measurement;Measures;member;Messenger RNA;Modeling;Molecular;Molecular Target;Morphology;mRNA Decay;Mus;Myopathy;Nervous System Disorder;Neurons;Nonsense Codon;Normal Cell;Normal tissue morphology;novel;Outcome;overexpression;pathway tools;Phenotype;Play;Poison;Positioning Attribute;Post-Transcriptional Regulation;Process;Proliferating;protein expression;Protein Isoforms;Proteins;Regulation;Reporter;RNA;RNA Recognition Motif;RNA Splicing;RNA-Binding Proteins;Role;Serine;Spliced Genes;Therapeutic;therapeutic development;tool;tool development;transcriptome sequencing;tumor;Untranslated RNA

PROJECT_TITLE: Mechanisms of post-transcriptional regulation of splicing factors

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE/ RELEVANCE  COVID-19, caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has caused over 6 million deaths and economic devastation worldwide; while several vaccines have been developed, there is a growing need for effective prophylactic treatments, especially for vulnerable populations. The goal of this highly collaborative proposed research is to develop potent lipopeptides that inhibit SARS-CoV-2 infection by blocking viral entry into host cells. Through structure-guided engineering and sophisticated and multi-pronged assay implementation, these efforts could generate effective pan-variant therapeutics for COVID-19.

PI_NAMEs: KUHN, ARIEL JADE (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Address;Amino Acid Substitution;Amino Acids;analog;Animal Model;Anti-viral Agents;Biodistribution;Biological Assay;Biological Availability;C-terminal;career;Cell membrane;Cells;Cessation of life;Chemicals;Cholesterol;Circular Dichroism;Collaborations;Coronavirus;coronavirus disease;COVID-19;COVID-19 therapeutics;Crystallization;Crystallography;Data;design;Development;Dose;Drug Kinetics;Economics;Engineering;Etiology;Exhibits;experience;Fluorescence Polarization;Foundations;Goals;Half-Life;HIV;Hybrids;improved;In Vitro;in vivo;Infection;inhibitor;insight;interdisciplinary approach;Learning;Length;Mediating;Membrane Fusion;Membrane Proteins;Middle East Respiratory Syndrome;mimicry;Modification;Molecular;Molecular Conformation;N-terminal;novel;novel strategies;novel therapeutics;pandemic disease;Para-Influenza Virus Type 3;Pathogenesis;Peptide Hydrolases;Peptides;Positioning Attribute;Predisposition;Productivity;Property;Prophylactic treatment;Protein Engineering;protein expression;Proteins;Proteolysis;Research;Research Personnel;Resistance;Resolution;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Side;Site;Structure;Surface;Techniques;Therapeutic Agents;Treatment Efficacy;Universities;Vaccines;Variant;Vertebral column;Viral;viral entry inhibitor;Viral Physiology;virology;Virus;Virus Diseases;Virus Inhibitors;Vulnerable Populations;Wisconsin;Work;X ray diffraction analysis;X-Ray Crystallography

PROJECT_TITLE: Structure-guided design of protease-resistant, lipopeptide inhibitors of SARS-CoV-2


ADMINISTERING_IC: MH

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Astrocytes are a heterogenous population of glial cells that play critical roles in neuronal circuit assembly and function in health and disease, but the molecular drivers of their heterogeneity remains poorly understood. This proposal seeks to characterize astrocyte molecular, structural, and functional diversity across development stages and brain regions in the rodent and primate brain using cutting-edge techniques. Detailed characterization of astrocyte subpopulations will enable their more precise manipulation for basic and translational research.

PI_NAMEs: SCHROEDER, MARGARET ELIZABETH (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Acute;Address;Adolescent;Adult;Aging;Architecture;Astrocytes;Atlases;Automobile Driving;Basic Science;Biological;Brain;brain cell;Brain Diseases;BRAIN initiative;Brain region;Calcium;Calcium Channel;Callithrix;Cataloging;Cell Nucleus;cell type;Cells;Censuses;Cognitive Science;Collaborations;Communities;Complex;Computational Technique;Computing Methodologies;Cues;Data;Development;differential expression;Disease;Embryo;Equipment;Etiology;Evolution;Fellowship;Functional disorder;Genes;Genetic Transcription;Glutamates;Goals;Health;Heterogeneity;Image;in silico;Ion Channel;Knowledge;Laboratories;Maps;Massachusetts;member;Mental disorders;Microscopy;Modeling;Molecular;Molecular Profiling;Morphologic artifacts;Morphology;Motor Cortex;multimodality;Mus;nanoscale;neonate;Neurodevelopmental Disorder;Neuroglia;neuron component;neuronal circuitry;Neurons;Neurosciences;Neurotransmitter Receptor;next generation;nonhuman primate;Pathogenesis;Pathway Analysis;Pattern;Physiological;Play;Population;Postdoctoral Fellow;postnatal development;Preparation;Primates;Printing;Process;Property;protein expression;Resource Development;Rodent;Role;Sampling;sequencing platform;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Slice;species difference;Synapses;Synaptic Transmission;Techniques;Technology;Training;transcriptomics;Translational Research;United States National Institutes of Health;young adult

PROJECT_TITLE: A multi-modal, brain-wide atlas of astrocyte diversity across developmental stages and model species


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Stress-induced activity of corticotropin releasing factor (CRF) has been shown to shift neuronal function in a variety of brain regions. The ventral pallidum is a basal ganglia structure that integrates environmental stimuli, and mediates motivated and reward-consumption behaviors. This proposal aims to investigate a potential mechanism underlying stress-induced potentiation of reward consumption, and posits that stress exposure, via CRF signaling, increases activity of a ventral pallidum population that expresses CRF receptor type 1.

PI_NAMEs: ECKENWILER, ELIZABETH ANNE (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Acute;acute stress;Address;Amygdaloid structure;Anhedonia;Animals;antagonist;approach behavior;avoidance behavior;Basal Ganglia;Bathing;Behavior;behavior prediction;Behavioral;behavioral outcome;Brain;Brain region;Cells;Chemosensitization;cholinergic neuron;Chronic;Chronic stress;Consumption;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;Coupled;CRF receptor type 1;Data;Dependence;desensitization;Detection;detector;Development;Disease;Electrophysiology (science);Fellowship;Frequencies;functional adaptation;Gases;Globus Pallidus;Glutamates;Goals;Immunohistochemistry;In Situ Hybridization;Individual;Intake;intraperitoneal;Investigation;Knowledge;Link;Measures;Mediating;Mental Depression;motivated behavior;Motivation;Mus;neurobiological mechanism;Neurobiology;neurochemistry;Neurons;Neuropeptides;Neurotransmitters;novel;Nucleus Accumbens;Output;Pharmaceutical Preparations;pharmacologic;Population;postsynaptic;Property;Protocols documentation;receptor;Receptor Cell;receptor expression;Receptor Signaling;recruit;Research;Research Personnel;response;reward processing;Rewards;Role;Signal Transduction;Slice;Stimulus;Stress;stressor;Structure;Substance Use Disorder;Swimming;Synapses;Synaptic Transmission;Testing;Time;Training;Viral

PROJECT_TITLE: Investigation of a novel ventral pallidum population expressing corticotropin-releasing factor receptor 1


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE: Diabetes is highly prevalent in the United States and is currently incurable. Therapeutic strategies to amplify and protect the endogenous β cell mass in patients are a major focus of research, with the hypusination pathway identified as a relevant avenue of investigation. Using both animal and in vitro models, this project will identify how accumulation of un-hypusinated eIF5A contributes to β cell loss under metabolic stress.

PI_NAMEs: ANDERSON, CARA  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acute;American;Amino Acids;Animal Model;Animals;Arginine;Beta Cell;biological adaptation to stress;Biology;Blindness;career development;Cause of Death;Cell division;Cell Line;Cell Physiology;Cell Proliferation;cell type;Cells;Chemicals;Chicago;Chronic;Clinical;comorbidity;Data;Data Analyses;deoxyhypusine synthase;detection of nutrient;Diabetes Mellitus;Diagnosis;Disabling;Disease;Disparity;doctoral student;EIF-2alpha;eIF-5A;Enzymes;Exhibits;experimental study;Fatty acid glycerol esters;feeding;Fostering;Future;Genes;glucose tolerance;Health;Heart Diseases;Homeostasis;Homologous Gene;hypusine;Impairment;In Vitro;in vitro Model;in vivo;in vivo Model;inhibitor;Insulin;Insulin Resistance;insulin secretion;Investigation;islet;Kidney Diseases;knock-down;Knockout Mice;Knowledge;Laboratories;Lead;Life;limb amputation;Literature;Macronutrients Nutrition;Manuscripts;meetings;Messenger RNA;Metabolic;Metabolic Diseases;Metabolic stress;Modeling;Modification;Molecular;mouse model;mRNA Translation;Mus;Nutrient;Nutritional Study;Pathway interactions;Patients;Phenotype;Phosphorylation;Phosphotransferases;Polyamines;pre-doctoral;Prediabetes syndrome;Prevalence;Principal Investigator;PRKR gene;Process;Production;programs;Proliferating;Protein Isoforms;Proteins;Public Health;Publications;Putrescine;Regulation;Research;Research Personnel;response;Risk;Role;Science;Signal Transduction;skills;small hairpin RNA;Spermidine;Spermine;Stimulus;Structure of beta Cell of islet;Therapeutic;Time;Training;Transcript;transcription factor;Transfection;Transfer RNA;translation factor;Translational Regulation;Translational Repression;Translations;type I and type II diabetes;United States;Universities;virtual;Writing

PROJECT_TITLE: Hypusine as a nutrient-sensing modulator of eIF5A function in β cells

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Narrative Chronic pain has estimated costs in the US of $635 billion annually , yet no scientifically validated therapy exists for such condition; as a consequence many patients receive long-term treatments with prescription opioids and risk becoming addicted. Recent data show that functional deactivation of the medial prefrontal cortex represents a critical step causing the pain phenotype, but the underlying cellular mechanisms remain largely unclear. We will take advantage of electrophysiological, chemo- and opto-genetic, behavioral, and molecular techniques to test the overarching hypothesis that impaired cholinergic modulation of the prefrontal cortex causes several emotional, cognitive and sensory symptoms of neuropathic pain and that pharmacological normalization of the cholinergic signaling importantly ameliorates the neuropathic pain phenotype.

PI_NAMEs: MARTINA, MARCO  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acetylcholine;Acute;addiction;Affect;Analgesics;Animals;antagonist;Attention;basal forebrain;Behavior;behavior test;Behavioral;Biological Process;cholinergic;Cholinergic Receptors;chronic pain;chronic pain management;Cognitive;cognitive performance;cognitive task;Control Animal;cost estimate;Data;Decision Making;Drug Delivery Systems;Drug Prescriptions;economic cost;effective therapy;Electrophysiology (science);Emotional;emotional symptom;Female;Genetic;Goals;Health Care Costs;High Prevalence;hippocampal pyramidal neuron;Impaired cognition;Impairment;in vivo;Individual;insight;Interneurons;Laboratories;Light;male;Medial;Mediating;Medical;Modeling;Molecular;Muscarinic M1 Receptor;Muscarinics;nerve injury;Neurobehavioral Manifestations;neurobiological mechanism;Neurobiology;Neurons;non-opioid analgesic;Opioid;Opioid abuser;optogenetics;Output;Pain;Pain management;pain perception;painful neuropathy;patch clamp;Patients;pharmacologic;Pharmacological Treatment;Phenotype;Positioning Attribute;Prefrontal Cortex;prescription opioid;Price;Productivity;Pyramidal Cells;Rattus;receptor;Risk;Rodent Model;Role;Sensory;sex;Shapes;Short-Term Memory;side effect;Signal Transduction;Slice;socioeconomics;spared nerve;success;Symptoms;Techniques;Testing;virtual;Work

PROJECT_TITLE: Modulation of the prefrontal cortical network in neuropathic pain

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Although neuronal loss following brain injury is generally considered permanent, new neurons are born in select locations in the mammalian brain and then integrated into specific neural circuitry (i.e. neurons born in the subventricular zone and then guided by the rostral migratory stream to the olfactory bulb). We have created the first implantable engineered microtissue that structurally and functionally emulates the glial tube of the rostral migratory stream, to date being biofabricated from both rodent as well as human cell sources. The current proposal will evaluate the efficacy of this approach to redirect endogenous newborn neurons to sites of focal degeneration in a preclinical model of traumatic brain injury, which if successful, would provide a regenerative medicine strategy for neuronal replacement potentially capable of mitigating the often devastating — and currently untreatable — cognitive and motor deficits in afflicted patients.

PI_NAMEs: CULLEN, DANIEL KACY (contact)

PROJECT_TERMS: Acute;Address;Adult;Affect;Aging;Alzheimer's Disease;Anatomy;Area;Astrocytes;Autologous;Beds;Behavioral;biofabrication;Biomedical Engineering;Brain;Brain Injuries;cell type;Cells;Cerebral cortex;Chronic;Chronic Brain Injury;Chronic disability;Clinical;clinical translation;Cognitive deficits;controlled cortical impact;Corpus striatum structure;Cues;dentate gyrus;Dependence;design;Development;disability;efficacy evaluation;efficacy testing;Engineering;Exhibits;fabrication;Future;Gingiva;Harvest;Human;human stem cell-derived;Implant;improved;In Vitro;in vitro testing;in vivo;Injury;injury recovery;innovation;insight;Lateral;Lesion;Location;Mesenchymal Stem Cells;Methods;migration;minimally invasive;Morphology;motor deficit;multidisciplinary;Natural regeneration;Nerve Degeneration;Nerve Regeneration;nerve stem cell;Nervous System Trauma;neural circuit;neuroblast;Neurodegenerative Disorders;neurogenesis;neuron loss;neuronal replacement;Neurons;Neurosphere;newborn neuron;non-genetic;novel;Nude Rats;olfactory bulb;Parkinson Disease;Pathway interactions;Patients;Persons;Population;Positioning Attribute;Pre-Clinical Model;prevent;Prosencephalon;protein expression;Proteins;Publications;Punch Biopsy;Rattus;Recovery;Recovery of Function;Regenerative Medicine;repaired;Reproducibility;Residual state;Rodent;self assembly;Signal Transduction;Site;Source;Specialist;stem cell fate;stem cell migration;stem cells;Stream;Structure;subventricular zone;Target Populations;Techniques;Testing;Tissue Engineering;tissue stem cells;Tissues;translational approach;Traumatic Brain Injury;Traumatic Brain Injury recovery;Tube

PROJECT_TITLE: Tissue Engineered Rostral Migratory Stream for Directed Neuronal Replacement

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: PROJECT NARRATIVE Motor commands to motoneurons have three components, excitation, inhibition and neuromodulation. Our goal is to implement motoneuron models on supercomputers and use the resulting computational power to reverse engineering motor neuron firing patterns to identify these three components in humans.

PI_NAMEs: HECKMAN, CHARLES  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Supercomputer-based Models of Motoneurons for Estimating Their Synaptic Inputs in Humans


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative In radiology today, we are frustrated daily by our inability to obtain useful diagnostic images in young children, who are often unable to remain still for long scan durations, without resorting to the use of sedation or anesthesia, which unfortunately are associated with the possibility of serious adverse side effects and add significantly to the cost of imaging. Thus, there is an urgent, unmet need for accurate, safe and reliable imaging techniques to offset the effects of uncontrolled, fast motion in children, to produce images of superior diagnostic value without the use of sedation, leading to effective diagnosis, treatment and monitoring of pediatric disease. The proposed project, “Improved Motion Robust MRI of Children” promises to deliver a highly innovative imaging method capable of producing high-quality images in the presence of large and frequent motion by tracking the position of the head and updating the acquisition in real-time, which will in turn remove the need for sedation, effectively eliminating potentially life-threatening side effects from the imaging equation.

PI_NAMEs: WARFIELD, SIMON K (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;8 year old;Address;Adverse event;Algorithms;anatomic imaging;Anesthesia procedures;brain magnetic resonance imaging;Cephalometry;Child;Child health care;Childhood;Clinical;clinical imaging;clinical practice;cohort;Compensation;Consumption;cost;Data;Diagnosis;Diagnostic;Diagnostic Imaging;diagnostic value;Disease;efficacy evaluation;Equation;experimental study;Frustration;Goals;Grant;Head;Head Movements;Image;image reconstruction;imaging modality;Imaging Techniques;Imaging technology;improved;innovation;Instruction;interest;Life;magnetic field;Magnetic Resonance Imaging;Measurement;Measures;Methods;Modeling;Monitor;Morphologic artifacts;Motion;novel;older patient;Patients;Physiological;Population;Positioning Attribute;Process;prospective;quantitative imaging;Radial;Radiology Specialty;reconstruction;recruit;Research;Resort;response;Risk;Sampling;Scanning;Schedule;Sedation procedure;Series;Serious Adverse Event;side effect;Signal Transduction;simulation;Source;spatial relationship;spatiotemporal;Speed;success;Techniques;Technology;Testing;Time;translational impact;United States National Institutes of Health;Update;Variant;verbal;volunteer

PROJECT_TITLE: Improved Motion Robust MRI of Children

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Brain Disorders;Infectious Diseases;Neurosciences;Rare Diseases;Regenerative Medicine;Sexually Transmitted Infections;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: 9. Project Narrative This project will investigate several aspects of the impact of herpes simplex virus 1 (HSV-1) infection on neurogenesis. We will investigate the effects of the virus on the neuronal progenitor cells proliferation, differentiation and migration, and whether HSV-1 can establish latency using human induced pluripotent stem cell (hiPSC)-based technologies and an animal model. Our long- term goal is to prevent or treat long term neurological sequelae caused by the virus.

PI_NAMEs: BLOOM, DAVID C.;D'AIUTO, LEONARDO  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 3-Dimensional;Acute;Acyclovir;adult neurogenesis;aged;Animal Model;Anti-viral Agents;Anti-viral Therapy;Antigens;Area;biological systems;Biology;Brain;cell motility;Cell Physiology;Cells;Central Nervous System Diseases;Central Nervous System Infections;Chronic;chronic infection;Complement;Confocal Microscopy;Data;Death Rate;design;Dose;Encephalitis;executive function;experimental study;Gene Expression;Genes;Genome;Goals;Herpes encephalitis;Herpes Simplex Infections;Herpesvirus 1;Hippocampus;Human;human induced pluripotent stem cells;human model;Immunocompetent;Impairment;improved;In Vitro;in vitro Model;in vivo;Incidence;Individual;induced pluripotent stem cell;Infection;insight;Investigation;Language;latent infection;lateral ventricle;Learning;Lesion;Limbic System;Lytic;Memory;migration;Modeling;mouse model;Mus;Neonatal;nerve stem cell;neurogenesis;Neuroglia;Neurologic;Neurologic Deficit;Neurons;Neurosphere;Organoids;Pathogenesis;Pathway interactions;Patients;Periodicals;permissiveness;Phase;Play;prevent;progenitor;Prognosis;programs;Proliferating;Protocols documentation;reactivation from latency;Resolution;Rodent;Role;Running;Severities;Simplexvirus;stem cell biology;stem cell differentiation;stem cell function;stem cell model;stem cell proliferation;Structure;subventricular zone;Survivors;System;Technology;three-dimensional modeling;transcriptome;transcriptome sequencing;Tropism;vaccine access;Virus;Work

PROJECT_TITLE: Effects of HSV-1 infection on neural progenitor cell biology in vitro and in vivo

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Clinical Research;Immunotherapy;Infectious Diseases;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Severe traumatic brain injury (TBI) in children remains one of the most common causes of childhood morbidity and mortality, and a known, common complication is post-injury nosocomial infection. TBI is frequently accompanied by systemic injuries (polytraumatic TBI), and these types of combined injuries are likely even more prone to post-injury immune suppression; however, there is little preclinical data examining the timeline for immune suppression following injury or how reversing post-injury immune suppression may affect the injured, recovering brain. This project seeks to identify therapies to treat post-injury immune suppression with the central hypothesis that post-injury immune suppression is an important acute and chronic sequela of critical injury that can be attenuated without negatively impacting neurological outcomes.

PI_NAMEs: SRIBNICK, ERIC ANTHONY (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acute;Adolescent;Adrenergic beta-Antagonists;adverse outcome;Affect;Animal Model;Animals;antagonist;Anti-Inflammatory Agents;anti-PD-1;anti-PD1 antibodies;Area;aspirate;Attenuated;attenuation;behavior test;Blood;Brain;Brain Injuries;career;Caring;Cause of Death;Cells;Central Nervous System;central nervous system injury;Cephalic;Child;Childhood;Childhood Injury;cholinergic;Chronic;Clinical;Clinical Trials;clinically relevant;Cognition;Cognitive;cohort;Complication;controlled cortical impact;Critical Illness;Data;Denervation;Development;disability;education planning;Elements;Enrollment;experience;experimental study;femoral artery;Foundations;Funding;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Hemorrhage;Human;Hypovolemia;Hypovolemics;IL7 gene;Immune;immune function;immune stimulatory agent;Immune Targeting;Immunohistochemistry;Immunologic Adjuvants;Immunologics;Immunology;Immunophenotyping;immunoregulation;Immunosuppression;Impaired cognition;Impairment;improved;improved outcome;Incidence;Infection;infection risk;Inflammation;Inflammatory Response;injured;Injury;Interferon Type II;K-Series Research Career Programs;Leukocytes;Life;Mediating;Medical;Memantine;member;Mentors;Methods;model design;Modeling;Morbidity - disease rate;mortality;Multiple Trauma;Nerve;Nervous System Trauma;neural;Neurocognitive;neuroimmunology;neuroinflammation;Neurological outcome;Nicotinic Receptors;Nosocomial Infections;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;pre-clinical;prevent;programs;Propranolol;prospective;Prospective cohort;Rattus;Recovery;Research;Research Design;Research Personnel;restoration;Risk;Rodent;Scientist;Secondary to;severe injury;Signal Transduction;skills;Surgeon;TBI Patients;Testing;Therapeutic;therapeutic target;therapy development;Time;timeline;tool;Training;Translational Research;Trauma;Traumatic Brain Injury;Traumatic injury;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: Reversal of Immunoparalysis Following Traumatic Brain Injury and Systemic Hemorrhage in a Juvenile Rat Model

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative Gestational duration and birth weight are important birth outcomes. They are associated not only with perinatal morbidity and mortality but also with long-term adverse health outcomes. This study will synthesize the genomic research of gestational duration and birth weight, to elucidate the genomic and phenotypic complexity of these birth outcomes and to understand how they are related to late onset diseases.

PI_NAMEs: FREATHY, RACHEL ;JACOBSSON, BO ;ZHANG, GE  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Adult;adverse birth outcomes;adverse pregnancy outcome;biobank;Biological Markers;Birth;Birth Weight;Child;Childhood;Clinical;Complex;Correlation Studies;Data;Disease;Dissection;DNA;Electronic Health Record;Equation;Etiology;European ancestry;fetal;Fetal Growth;Genetic;Genetic Diseases;genetic variant;Genome;genome wide association study;genome-wide;genomic locus;Genomics;Gestational surrogate;Health;Human;Human Biology;Infant;Inflammatory;insight;Intervention;Joints;Knowledge;large datasets;Late-Onset Disorder;Life Cycle Stages;Link;Measures;Methods;Modeling;Molecular;Mothers;multiple omics;novel;Outcome;Pathway Analysis;Pathway interactions;perinatal morbidity;Perinatal mortality demographics;phenomics;Phenotype;phenotypic data;Population Heterogeneity;Pregnancy;Pregnancy Outcome;Premature Birth;prevent;Research;Research Personnel;Sample Size;Shapes;Statistical Methods;success;Testing;Therapeutic;Transcend;Variant;Work

PROJECT_TITLE: Integrating genomic studies of gestational duration and birth weight to understand maternal and fetal causes of adverse pregnancy outcomes and links with later diseases

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: KNOXVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: Narrative/Public Health Impact Despite the fact that safe and effective endoscopic procedures for removal of colon lesions have been demon- strated in the academic literature, over 60,000 patients per year in the USA alone still undergo invasive surgery to remove sections of their colons. The culprit for this is the lack of dexterity in tools passed through conventional colonoscopes, making procedures so challenging that only a small number of the best endoscopists can attempt them. To help more patients beneﬁt from minimally invasive, endoscopic approaches, we propose a new dex- terous steerable instrument sheath that is thin enough to ﬁt through the port of a conventional colonoscope and provides dexterity, enabling endoscopists to perform complex surgical motions easily inside a patient's colon.

PI_NAMEs: RUCKER, DANIEL CALEB (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Address;Animal Model;Animals;Clinical;clinical imaging;clinical translation;clinically significant;Colectomy;Colon;Colonoscopes;Colonoscopy;Complex;Computer software;cost;Custom;Databases;design;design verification;Devices;dexterity;Diameter;Dissection;Elasticity;Elements;Endoscopes;Excision;experimental study;Family suidae;Future;Geometry;Goals;improved;in vivo;Incidence;innovation;instrument;Intervention;Intestines;Intuition;Lesion;Literature;Location;Malignant Neoplasms;Mechanics;minimally invasive;Modeling;Motion;nitinol;Operative Surgical Procedures;Outpatients;Patients;Physicians;Polyps;porcine model;Procedures;Property;prototype;Public Health;Robotics;safety and feasibility;Shapes;standard of care;Surgeon;Surgical Instruments;System;Testing;Thinness;tool;transmission process;Tube;Validation;Work

PROJECT_TITLE: Saving patients from invasive colectomies via trans-endoscopic steerable instrument sheaths

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Nutrition

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: || PROJECT NARRATIVE Iron deficiency is the cause for over 50% of anemias and is associated with heart failure, chronic kidney disease, and chronic inflammation. Because all of these diseases are associated with abnormal endothelial function, it is critical to understand how changes in systemic iron impact endothelial function. This project investigates iron-induced changes in hemoglobin alpha, a key regulator of endothelial function, as a novel mechanism by which iron regulates endothelial function.

PI_NAMEs: DUNAWAY, LUKE STEWART (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: alpha(A) globin;Anemia;Arteries;Biochemical;Biological Assay;Biological Availability;Blood flow;Blood Vessels;Cardiovascular Diseases;career;Chronic;Chronic Disease;Chronic Kidney Failure;Complex;Data;Disease;Endothelial Cells;endothelial dysfunction;Endothelium;Erythrocytes;Etiology;exercise capacity;Feline Leukemia Virus;Fellowship;Foundations;Goals;Heart failure;Heme;heme a;Hemeproteins;Hemoglobin;Homeostasis;Impairment;improved;in vivo;Inflammation;insight;Intravenous;Iron;iron deficiency;Iron deficiency anemia;Iron Overload;Knock-out;Knockout Mice;Knowledge;Laser Speckle Imaging;Learning;Link;Mediating;Messenger RNA;Micronutrients;Modeling;Molecular;mouse model;Mus;Nitric Oxide;Nitrites;Nitrogen Dioxide;novel;Oxidation-Reduction;Oxygen;Patient-Focused Outcomes;Patients;Peptides;Phenotype;Production;Protein Export Pathway;Protein Import;Publications;receptor;Regulation;Research Personnel;Resistance;Role;Signal Transduction;single-cell RNA sequencing;Subgroup;Techniques;Testing;TFRC gene;Tissues;translational potential;Up-Regulation;uptake;Work

PROJECT_TITLE: Iron Regulation of Endothelial Hemoglobin Alpha

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


NIH_SPENDING_CATS: Regenerative Medicine

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative: Defects in endothelial cell specification causes embryonic lethality, vascular malformations, and contributes to many diseases; however, the mechanisms regulating endothelial cell specification are poorly understood. We propose that cell cycle control is necessary for proper endothelial cell specification and that its loss will lead to immature and malformed vasculature. Completion of these studies will reveal novel mechanisms that regulate arterial and venous vessel formation, which will aid in the creation of clinical and regenerative therapies for vascular pathologies.

PI_NAMEs: ARAGON, JORDON  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: angiogenesis;Blood;Blood capillaries;Blood flow;Blood Pressure;blood pressure regulation;Blood Vessels;BMP4;Cardiovascular Diseases;Cardiovascular system;cdc Genes;Cell Cycle;Cell Cycle Regulation;Cell Differentiation process;Cell Line;Cells;cerebral cavernous malformations;Characteristics;Clinical;Data;Defect;Development;Disease;Dorsal;Embryo;Embryonic Development;Endothelial Cells;Endothelium;Exhibits;Fluorescence-Activated Cell Sorting;Future;gain of function;Gases;Gene Expression;Genes;Homeostasis;Human;human stem cells;Immune;Immunohistochemistry;improved;in vivo;inhibitor;injured;insight;Ligands;loss of function;malformation;Malignant Neoplasms;Mediating;Modeling;Mus;neuron development;notch protein;novel;Nutrient;Pathologic;Pathology;postnatal;Process;progenitor;receptor;Regenerative Medicine;regenerative therapy;Regulation;Reporter;Retina;retinal angiogenesis;revascularization;Role;shear stress;Signal Transduction;single-cell RNA sequencing;Sorting;Specific qualifier value;Testing;Tissues;trafficking;transcriptome;transcriptome sequencing;Transforming Growth Factor beta;tumor;Tumor Angiogenesis;Ubiquitination;Up-Regulation;Vascular remodeling;vascular tissue engineering;Vascularization;Veins;Venous;Venous Malformation;venule;wasting;Work

PROJECT_TITLE: Cell Cycle Control Of Arterial-Venous Specification Within the Developing Embryo


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: SILVERTHORNE

ORG_NAME: KEYSTONE SYMPOSIA

ORG_STATE: CO

PHR: PROJECT NARRATIVE Nucleic acid therapeutics, including DNA and RNA-based drugs, have emerged as promising treatments for many diseases. Nucleic acids offer a high degree of specificity and selectivity for their targets, making them potentially safer and more effective than traditional small molecule drugs, but their delivery to specific cells and tissues remains a central challenge. This Keystone Symposia conference will assemble researchers who bring diverse scientific perspectives and methodologies to advance the field of nucleic acid therapeutics toward broader clinical applications.

PI_NAMEs: SHEPPARD, TERRY L. (contact)

PROGRAM_OFFICER_NAME: CHEN, ALICE

PROJECT_TERMS: Address;Alberta province;Antisense Oligonucleotide Therapy;Area;Attention;Automobile Driving;Basic Science;Biology;Canada;Cells;Chemistry;clinical application;clinical practice;Collaborations;Communities;Complex;COVID-19 vaccine;design;Development;Discipline;Disease;DNA;Drug Delivery Systems;Educational workshop;Engineering;experience;Future;Gene Delivery;Genes;Genetic Medicine;Genome engineering;Hearing;improved;Industrialization;International;Joints;Knowledge;Learning;Liver;materials science;Medical;Medicine;meetings;Mentors;Messenger RNA;method development;Methodology;multidisciplinary;novel;nucleic acid delivery;nucleic acid-based therapeutics;Nucleic Acids;Organ;Outcome;Pharmaceutical Preparations;posters;prospective;Reagent;Research;Research Personnel;Research Priority;RNA;Science;Scientist;small molecule;Specificity;success;symposium;System;targeted delivery;Technology;Tissues;Toxic effect;Translational Research;vaccine development;Vaccines

PROJECT_TITLE: Delivery of Nucleic Acid Therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CG-4 (02)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Cardiac hypoxia is a prominent contributor to the pathophysiology of a myriad of cardiac diseases, constituting the leading causes of morbidity and mortality in the world. Cardiomyocytes have an innate ability to adapt to mild hypoxia through fuel switching over chronic timescales, however, the molecular mediators of this transition have not been fully elucidated. The goal of this proposal is to gain a comprehensive understanding of the pathways that facilitate adaptive and maladaptive metabolic rewiring (particularly for fuel use) in hypoxic CMs, with the long-term goal of targeting these pathways as novel therapeutics.

PI_NAMEs: FLANIGAN, WILL ROBERT (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Action Potentials;Acute;Address;Admission activity;Aerobic;Altitude;anaerobic glycolysis;Biological Assay;Calcium;calcium indicator;Carbon;Cardiac;Cardiac Myocytes;Cell Respiration;cell type;Cells;Chronic;Chronic Obstructive Pulmonary Disease;Citric Acid Cycle;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Cyanotic heart disease;Data;Dependence;deprivation;design;Diabetes Mellitus;Disease;Electrophysiology (science);experimental study;Exposure to;fatty acid oxidation;Fatty Acids;flexibility;Functional disorder;functional genomics;Future;Genetic;Genetic Transcription;genome-wide;Genomic approach;genomic platform;Glucose;glucose uptake;Goals;Heart;Heart Arrest;heart damage;Heart Diseases;Heart failure;heart function;HIF1A gene;Hyperglycemia;Hypoxia;improved;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;insight;Intervention;Ischemic Preconditioning;Isotopes;Ketone Bodies;knock-down;Label;Measures;Mediator;Metabolic;Metabolic Pathway;Metabolism;Microelectrodes;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;myocardial hypoxia;Myocardial Ischemia;new therapeutic target;novel;novel therapeutics;nucleotide metabolism;Nutrient;Organ;Organ failure;Organism;Outcome;oxidation;Oxygen;Pathologic;Pathology;Pathway interactions;Patients;Pentosephosphates;Physiological;Population;Pre-Clinical Model;preference;programs;protective pathway;Pulmonary Pathology;response;Screening Result;Source;Stress;System;Testing;Therapeutic;therapeutic target;Time;Tissues;Toxic effect;Tracer;Work

PROJECT_TITLE: Systems genomics approach to targeting glucose toxicity during pathological cardiomyocyte hypoxia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


ADMINISTERING_IC: EY

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE By determining the role of locomotion in inter-areal communication, we seek to understand how communication in the brain can be altered or improved by behavior. Better understanding of inter-areal signaling may provide important insights into the neural substrates of disorders where signaling is altered, as in autism and schizophrenia. Understanding changes in inter-areal communication with behavior may help us elucidate mechanisms of existing therapies, such as mirror therapy, music therapy, and mindfulness, as well as develop new therapies that help to restore optimal inter-areal communication.

PI_NAMEs: KIM, ELLIOT  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Affect;analytical method;Anterior;Area;area striata;autism spectrum disorder;awake;Behavior;Behavioral;Biological Models;Brain;Communication;Data;density;Disease;Exercise;expectation;extrastriate visual cortex;Feedback;flexibility;Goals;improved;Individual;insight;Locomotion;mindfulness;Modeling;Modernization;Motion;Motor Cortex;Mus;Music Therapy;Nature;neural;Neurologic;neuronal patterning;Neurons;Neurosciences;novel therapeutics;Organism;Pattern;Population;Research;response;Role;Schizophrenia;Sensory;sensory input;signal processing;Signal Transduction;System;Testing;transmission process;virtual reality;virtual reality environment;Visual;visual feedback;visual information;visual motor;visual processing;visual stimulus;Visual System;Work

PROJECT_TITLE: Effects of locomotion on visual inter-areal processing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: We will develop a set of cutting-edge methods to: (i) reliably identify connected neurons in superficial and deep brain structures, (ii) visualize and physiologically characterize these neurons within a larger population using advanced scanning laser imaging and high density multielectrode recordings, and (iii) analyze the population dynamics in the context of an ethologically relevant behavioral task. Our findings will reveal how brain regions communicate and integrate sensory signals and prior knowledge to support complex perceptual behavior. Ultimately, our studies will bring us closer to devising strategies to alleviate and treat brain disorders of impaired object recognition resulting from dysfunctions in the occipito-temporal pathway (e.g. agnosia) and from diminished communication between visual and prefrontal cortex (e.g. autism).

PI_NAMEs: BAIR, WYETH DANIEL;PASUPATHY, ANITHA  (contact);WU, ANQI

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Agnosia;Anesthesia procedures;Animal Model;Animals;Area;area V4;autism spectrum disorder;awake;Bayesian Analysis;Behavior;Behavior Control;Behavioral;Brain;Brain Diseases;Brain region;calcium indicator;Chronic;Cognitive;Collaborations;Communication;Complex;Computer Models;Decision Making;density;Detection;Dissection;Distant;Electrodes;Ensure;Environment;Ethology;executive function;experience;frontal lobe;Functional disorder;Future;Goals;head-to-head comparison;Histologic;Histology;Image;Impairment;in vivo;insight;Knowledge;Label;Lasers;Lead;Lentivirus;Macaca;Methodology;Methods;Modeling;Monkeys;Morphologic artifacts;Motion;Motor;multiphoton imaging;Neurons;neurophysiology;Neurosciences;nonhuman primate;object recognition;Opsin;optogenetics;Pathway interactions;Perception;Photons;Physiological;Population;Population Dynamics;Poverty;Prefrontal Cortex;Primates;Process;Protocols documentation;Pulvinar structure;response;retinal imaging;Scanning;Science;Sensory;sensory integration;Shapes;Signal Transduction;Specific qualifier value;Stimulus;Structure;System;Task Performances;technique development;Techniques;Testing;tool;Toxic effect;Training;Viral;Vision;Visual;Visual Cortex;visual processing;Visualization

PROJECT_TITLE: Integrative circuit dissection in the behaving nonhuman primate


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: We will continue to use the touch receptor neurons of the nematode Caenorhabditis elegans to study basic questions about nerve cell development (how are cells ensheathed by surrounding tissue) and mechanosensation (what is the structure of the transduction channel, what genes negatively regulate touch). The importance of this research to public health derives from the similarity of the nematode genes to those of humans and the fact that, as many people have remarked, one must have something to translate to do translational research. Genetic approaches such as those that we use provide the new players and novel insights into biological functions that not only increase our general knowledge, but also provide new ways to address and understand the processes that go awry in disease.

PI_NAMEs: CHALFIE, MARTIN  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Acetyltransferase;Address;Adhesions;Affect;alpha Tubulin;axon guidance;Axonal Transport;beta Tubulin;Binding;Biological Process;Caenorhabditis elegans;Cell Differentiation process;Cells;Cholesterol;Collection;Complex;Cryoelectron Microscopy;Development;Disease;experimental study;Extracellular Matrix;Future;Gap Junctions;gene discovery;Generations;Genes;Genetic;genetic analysis;genetic approach;Goals;Grant;Health;Heat-Shock Proteins 90;Human;Individual;insight;Knowledge;Maintenance;Mammals;Mechanics;Molecular Chaperones;Molecular Structure;mutant;Mutation;Nematoda;Neurites;Neuronal Differentiation;Neurons;novel;Persons;Phenotype;prevent;Process;protein degradation;Public Health;receptor;Research;Specific qualifier value;Structure;System;Tissues;tool;Touch sensation;transcription factor;Transcription Repressor;Translating;Translational Research;Tubulin;Visit;Work

PROJECT_TITLE: Genetic analysis of nematode cell differentiation

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The University of Michigan's Clinical Research in Digestive Diseases (CRDD) Training Program provides patient-oriented clinical research training to physician-scientists whose goal is to improve the treatment of digestive diseases. The purpose of this training is to produce outstanding clinically oriented medical researchers who investigate the causes, prevention, and treatment of digestive diseases. Since 2003, our trainees have fulfilled this goal, and 95% of our graduates are now faculty at academic medical centers, being awarded multiple research grants, and producing numerous publications of their research work over the past 19 years of funding, leading to improved care and outcomes in a broad range of digestive diseases.

PI_NAMEs: HIGGINS, PETER D.R. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Clinical Research;Digestive System Disorders;Training Programs


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: NEUROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE This institutional training grant will provide stipends for post-doctoral trainees wishing to pursue a career in research to better understand the mechanisms or the utility of complementary and integrative health approaches to maximize nervous system health or treat dysfunction/disorders of the nervous system including those related to stress. The trainees will learn from formal classroom settings, monthly journal clubs, annual retreat, and from working closely with their successful primary and co-mentors.

PI_NAMEs: OKEN, BARRY S (contact);SOUMYANATH, AMALA

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Neurosciences;Research Training;Stress

PROJECT_TITLE: CAM Research Training in Neuroscience & Stress


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Rare Diseases

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative  Head and neck squamous cell carcinomas (HNSCCs) confer significant morbidity and mortality that associate with older age, yet preclinical models predominately focus on outcomes in young animals, possibly underlying the poor efficacy of current pharmacological treatments. We propose to test how age impacts the cellular, epigenetic, and transcriptional behavior of a syngeneic orthotopic xenograft model of HNSCC. Our study will provide a comprehensive characterization of tumors in different aged niches, providing insight to age- associated mechanisms of pro-tumorigenic phenotypes that may be targeted for the future development of treatments to improve clinical outcomes for patients.

PI_NAMEs: SPINELLA, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: acute myeloid leukemia 1 protein;Adolescent;Aftercare;Age;age effect;age related;age related changes;aged;Aging;Alternative Therapies;animal old age;ATAC-seq;Behavior;behavior in vitro;Bioinformatics;Biological Assay;Biological Markers;Biology;C57BL/6 Mouse;Cancer Model;cell behavior;Cell Separation;Cells;cellular targeting;Chromatin;Chromosomes;Cleavage Under Targets and Release Using Nuclease;Clinical;Collagen;Coupled;crosslink;Data;Deposition;Disease Progression;DNA-Binding Proteins;Elastin;Elderly;Enzymes;Epigenetic Process;epigenomics;Event;Exhibits;Extracellular Matrix;Fibroblasts;Future;Gene Expression;Gene Expression Profile;Genetic;Genetic Transcription;Genomics;Goals;Guidelines;Head and Neck Squamous Cell Carcinoma;HPV-negative head and neck cancer;human old age (65+);Human papilloma virus infection;Immune;Immune Evasion;Immunofluorescence Immunologic;Immunohistochemistry;improved;in vivo Model;insight;juvenile animal;Life;LOX gene;Lymphocyte;Malignant Neoplasms;Maps;mechanical signal;Mechanics;Mediating;Molecular;Morbidity - disease rate;mortality;Mouth Neoplasms;mouth squamous cell carcinoma;Mus;Mutation;Myelogenous;neoplastic cell;novel;novel therapeutics;Nuclear;older patient;Operative Surgical Procedures;Oral;oral tissue;Outcome;patient population;Patient-Focused Outcomes;permissiveness;Pharmacological Treatment;Pharmacotherapy;Phenotype;Physicians;Play;Population;pre-clinical;Pre-Clinical Model;preclinical study;programs;Property;Protein-Lysine 6-Oxidase;Proteins;Radiation therapy;Risk Factors;Role;Scientist;Severity of illness;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skills;Squamous cell carcinoma;Study models;success;Survival Rate;Testing;Therapeutic;therapeutic target;therapy development;therapy resistant;Tissues;Tobacco use;Tongue;Training;transcription factor;transcriptome;transcriptomics;translational medicine;Treatment Efficacy;treatment response;tumor;tumor behavior;tumor growth;tumor microenvironment;Tumor Tissue;tumorigenesis;tumorigenic;Xenograft Model

PROJECT_TITLE: Defining age-associated alterations in oral squamous cell carcinoma


NIH_SPENDING_CATS: Allergic Rhinitis (Hay Fever);Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative Excessive sneezing and ensuing rhinorrhea are the cardinal symptoms of allergic rhinitis. This proposal will characterize the role of a highly restricted population of nasal sensory fibers in detecting both histamine and non-histamine mediators released from mast cells and mediating sneezing in allergic rhinitis. These studies will advance our understanding of the neuro-immune interactions in allergic sneezing and unravel new drug targets for controlling nasal symptoms in allergy.

PI_NAMEs: LIU, QIN  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Ablation;Acute;Address;aerosolized;Afferent Neurons;Air;Allergens;Allergic;Allergic rhinitis;Antihistamines;Attenuated;Axon;Basic Science;Behavior;Behavioral;Brain Stem;Burning Pain;Calcium;Capsaicin;Cell Degranulation;Cells;Chemicals;Chili Pepper;cholinergic;Chronic;Clinical;Clinical Research;Common Core;Defense Mechanisms;designer receptors exclusively activated by designer drugs;Detection;Development;Environmental Irritants;Esthesia;Fiber;fiber cell;G-Protein-Coupled Receptors;Genetic;genetic approach;Histamine;Human;Hypersensitivity;IgE;imaging approach;Imaging Device;Immune;Immunologics;Infection;insight;Irritants;Label;Light;Lung;mast cell;Mediating;Mediator;Modeling;Mucous Membrane;Mus;nerve supply;Neuroimmune;neuromechanism;Neurons;neuropeptide FF;neurotransmission;new therapeutic target;Nose;novel;novel therapeutics;pathogen;Pathologic;Pattern;pharmacologic;Physiological;Pilot Projects;Play;Population;prevent;Productivity;Property;Pruritus;Quality of life;Reflex action;Respiration;response;Role;Sensory;sensory stimulus;Signal Transduction;Sneezing;Stimulus;Structure of mucous membrane of nose;Structure of trigeminal ganglion;symptomatology;Symptoms;Testing;Therapeutic;Wild Type Mouse

PROJECT_TITLE: The Neural Mechanism of Respiratory Allergies and Infections

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE This project will develop microPRO-seq (μPRO-seq), which will use only a minimum number of cells to generate a comprehensive multidimensional readout for gene regulation in human immune cells. The new streamlined μPRO-seq assay will quantify both actively expressed genes as well as active enhancers; our sample-sparing method will be an unparalleled tool for both researchers and clinicians in improving gene- targeted research, diagnosis and therapies in humans.

PI_NAMEs: GRIMSON, ANDREW W (contact);SCHEIBLE, KRISTIN

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Age;analysis pipeline;ATAC-seq;base;Binding;Biological Assay;Biology;candidate identification;cell type;Cells;clinical diagnostics;clinically relevant;Communities;computerized tools;cost;cost effective;Data;Data Set;design;Detection;Diagnosis;Dimensions;DNA-Directed RNA Polymerase;dynamic system;Enhancers;Female;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Order;gene synthesis;Gene Targeting;Genes;genetic regulatory protein;Genetic Transcription;Genome;genome-wide;Genomics;Goals;Human;Immune;Immune response;Immune system;Immunologics;Immunology;improved;Individual;informatics tool;Liquid substance;male;Maps;Measures;Messenger RNA;Methodology;Methods;Modernization;multimodality;multiple datasets;multiple omics;Mus;next generation sequencing;novel;Nucleotides;Output;Performance;personalized medicine;Polymerase;Positioning Attribute;Precision Run-On Sequencing;programs;promoter;Protocols documentation;Reaction;recruit;Regulatory Element;Reproducibility;Research;Research Personnel;Resources;response;Rest;RNA;Sampling;Scientific Advances and Accomplishments;Specific qualifier value;Stimulus;System;T-Lymphocyte Subsets;Targeted Research;Technical Expertise;Technology;Time;tool;transcription factor;transcriptome sequencing;user-friendly;Validation;Variant

PROJECT_TITLE: A Single Comprehensive Assay for Gene Regulatory Profiling Optimized for Minimal Sample Input Requirements


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Burden of Illness;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative The World Health Organization (WHO) recently launched a Call to Action to eliminate cervical cancer by 2030, with aggressive goals for vaccination, screening, and treatment. To scale-up screening, there must be a low-cost, effective test for the human papillomavirus (HPV) that allows women to collect their own samples and returns results the same day to treat those who screen positive. The current research will show that self- collection of AmpFire®, a new affordable test for HPV, will be superior in efficacy to the current test used in low-resource settings, allow for a single-visit approach to decrease loss to follow-up, and provide a cost- effective approach that aids in the effort to eliminate cervical cancer.

PI_NAMEs: CREMER, MIRIAM  (contact)

PROGRAM_OFFICER_NAME: SAHASRABUDDHE, VIKRANT V

PROJECT_TERMS: Ablation;Age;Area;Biomedical Engineering;Biopsy;Caring;Cervical;Cervical Intraepithelial Neoplasia;Clinical;Clinical Trials;Collection;Colposcopy;comparative efficacy;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;Cost Measures;cost-effectiveness evaluation;Country;Data;Detection;disability-adjusted life years;Disease;economic cost;efficacy testing;El Salvador;Electricity;Eligibility Determination;Environment;Epidemiology;Evaluation;Female Adolescents;field study;Financial cost;follow-up;Goals;Guidelines;Health;health economics;Health Planning Organizations;Health system;Hour;HPV positive;HPV screening;Human papilloma virus infection;Human Papillomavirus;Incidence;industry partner;Lesion;Location;low and middle-income countries;Malignant neoplasm of cervix uteri;Measures;member;Methods;mortality;Pathology;Patients;portability;premalignant;Prevalence;Process;programs;Protocols documentation;Provider;Public Health;Research;Resource-limited setting;Running;Sampling;scale up;screening;Screening Result;Sensitivity and Specificity;Specimen;statistics;Technology;Testing;timeline;Treatment Cost;treatment strategy;Vaccinated;Vaccination;Vagina;Validation;Visit;Woman;Work;World Health Organization

PROJECT_TITLE: Single Visit Clinical Validation of ScreenFire, a Low-Cost HPV Test: Efficacy and Cost Effectiveness (SCALE)


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Due to the extreme complexity of the brain, we still have a very limited understanding of how different cells in our brains work together to give rise to our behaviors. Through development of novel technologies that enable non-invasive, precise, selective excitation and/or inhibition of brain cells while measuring high-resolution videos of the associated whole brain interactions during behavior, we aim to reverse-engineer the brain function algorithms underlying behavior. Upon success, these measurements will enable quantitative description of normal brain function and how it changes during brain disorders including Alzheimer's disease and related dementias or pain leading to opioid crisis, which in turn will enable us to systematically design therapies that can restore normal brain circuit function.

PI_NAMEs: LEE, JIN HYUNG  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Alzheimer's disease related dementia;Animals;awake;Award;Behavior;Behavior Control;Behavioral;Brain;brain cell;Brain Diseases;Brain imaging;cell type;Cells;Complex;Computer Models;Data;Development;Electrical Engineering;Electronics;Engineering;flexibility;Functional Magnetic Resonance Imaging;Goals;Human;Image;imaging capabilities;Imaging technology;Implant;Ion Channel;Measurement;Measures;Mechanics;miniaturize;Monitor;Nervous System Disorder;Neurons;neuroregulation;Neurosciences;new technology;novel strategies;Operative Surgical Procedures;opioid epidemic;Optics;optogenetics;Output;Pain;Pain management;Population;real-time images;Resolution;Reverse engineering;spatiotemporal;Specificity;Subject Headings;success;Technology;technology development;therapy design;translation to humans;Ultrasonography;ultrasound;Work

PROJECT_TITLE: From Optogenetic Functional MRI to Mechanogenetic Functional Ultrasound


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Heart Disease;Heart Disease - Coronary Heart Disease;Patient Safety

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Results from the proposed ISCHEMIA-EXTEND study will tell us if heart disease patients with abnormal stress tests live longer if they have treatment of their narrowed arteries with surgery or stents in addition to medication and a healthier lifestyle. This information should help patients and their doctors decide which treatment is best. This research will also help doctors and scientists understand the impact of heart attack and other heart events on later risk of death, and to create a score to predict survival for people with heart disease.

PI_NAMEs: HOCHMAN, JUDITH S (contact)

PROGRAM_OFFICER_NAME: KIRBY, RUTH

PROJECT_TERMS: acute coronary syndrome;Adherence;Anatomy;Angiography;Arteries;Biological Markers;Cardiac Catheterization Procedures;cardiovascular risk factor;Cardiovascular system;Categories;Cause of Death;Cessation of life;Clinical;clinical diagnosis;clinical practice;Clinical Research;cohort;Comparative Study;Consensus;Consent;Coronary;Coronary Arteriosclerosis;Coronary Artery Bypass;Data;Databases;Development;diagnostic criteria;Effectiveness;Electrocardiogram;electronic data capture system;Electronic Mail;Event;Failure;follow-up;Follow-Up Studies;Goals;Guidelines;Health;Health Policy;healthy lifestyle;Heart;Heart Arrest;heart disease risk;Heart Diseases;Heart failure;high risk;Hospitalization;improved;International;Intervention;Investments;Ischemia;Left Ventricular Dysfunction;Letters;Life Style;Light;Longterm Follow-up;Medical;mortality;mortality risk;Myocardial Infarction;Myocardial Ischemia;National Heart, Lung, and Blood Institute;Online Systems;Operative Surgical Procedures;Outcome;Participant;participant retention;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;phenotypic data;Practice Guidelines;primary endpoint;primary outcome;Procedures;prognostic;prognostic significance;programs;Protocol Compliance;Protocols documentation;Proxy;Quality of life;Randomized;randomized trial;Recommendation;Research;revascularization;Risk;Scientist;secondary endpoint;Secure;Selection for Treatments;Societies;Source;Stents;Stress Tests;Subgroup;survival prediction;Symptoms;Telephone;Testing;treatment group;Unstable angina;Vital Status;Writing

PROJECT_TITLE: The International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial EXTENDed Follow-up (EXTEND)

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE  We propose to conduct a well-powered multi-omics study to discover novel methylation markers and novel genes for breast cancer risk in three racial groups. Findings from our association study, together with integrative bioinformatics and functional experiments, will greatly improve our understanding of novel mechanisms for genetic effects on breast cancer. The identified methylation markers could be used in risk-assessment and risk-stratifying for the prevention of breast cancer.

PI_NAMEs: LONG, JIRONG  (contact);YE, FEI

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: ABCC1 gene;African ancestry;African Women;Asia;Asian;Asian ancestry;Bioinformatics;Biological;Biological Assay;Biological Process;Breast;Breast Cancer cell line;Breast Cancer gene;Breast Cancer Genetics;Breast Cancer Prevention;Breast Cancer Risk Factor;Breast Epithelial Cells;Cancer Biology;carcinogenesis;causal variant;Cell Physiology;Clustered Regularly Interspaced Short Palindromic Repeats;cost;cost efficient;Data;density;Development;Diagnostic;Disease susceptibility;disorder prevention;DNA Methylation;Epigenetic Process;epigenetic regulation;ERBB2 gene;Estrogen Receptors;European;European ancestry;experience;experimental study;Freezing;functional genomics;Gene Expression;Genes;Genetic;Genetic Diseases;Genetic Models;Genetic study;genetic variant;genome wide association study;genome wide methylation;genomic data;genomic locus;Genomics;Genotype;Goals;improved;In Vitro;innovation;instrument;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Maps;Methylation;methylation biomarker;methylation pattern;methylome;Modeling;Modification;multi-racial;multiple omics;novel;Participant;Pathogenesis;Pathway interactions;Pilot Projects;Play;Positioning Attribute;predictive modeling;Prevention;Race;racial population;Regulation;Research;Resources;Risk Assessment;risk stratification;Role;Sampling;Series;Site;Susceptibility Gene;System;Testing;Tissue Banks;Tissue Sample;Tissues;transcriptome;transcriptomics;Translating;translational genetics;Variant;Woman

PROJECT_TITLE: DNA Methylation Markers, Genes and Breast Cancer Risk


ORG_NAME: SOCIETY FOR INVESTIGATIVE DERMATOLOGY

PHR: The Society for Investigative Dermatology (SID) Retreat is an annual conference specifically designed to increase the number of dermatology residents and PhD trained skin scientists that enter academia. The SID Retreat provides formal and informal mentoring and panel discussions focused on career development, work-life balance, career paths, obtaining research funding, and provides useful information about circumventing barriers to entry into academia and insight into grant funding opportunities and the publication process. The ability to increase the pipeline of multidisciplinary educators and scientists focused on skin biology, wellness and disease supports the mission of the SID to advance sciences relevant to skin disease through education, advocacy and scholarly exchange of scientific information and will help identify, retain, and support future generations of dermatologists and investigative skin scientists.

PI_NAMEs: MINNILLO, REBECCA M;WARD, NICOLE LEANNE (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Academia;Academic skills;Accreditation;Address;Administrator;Advocacy;Advocate;Age;applied biomedical research;Appointment;Area;Attention;Basic Science;Biology;Biomedical Research;care providers;career;Career Choice;career development;career life balance;Clinical;Clinical Investigator;Clinical Research;Data;Decision Making;Dermatologic;Dermatologist;Dermatology;design;Directories;Disease;diversity and inclusion;Doctor of Philosophy;Economics;Education;Educational process of instructing;effectiveness evaluation;Ensure;experience;Exposure to;Faculty;Fostering;Funding;Funding Opportunities;Future;Future Generations;Gender;Geography;Goals;Grant;Health;Human Resources;Individual;Industry;informal atmosphere;insight;Institution;interest;Joints;Knowledge;Legitimacy;Measures;Mediation;medical specialties;Medicine;meetings;member;Mentors;Mind;Mission;multidisciplinary;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nature;next generation;Occupations;Outcome;Outcome Measure;Patient Care;Patients;peer;people of color;Perception;Physicians;Play;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Process;programs;Publications;Race;recruit;Research;research faculty;Research Personnel;Residencies;Role;satisfaction;Science;Scientist;Seasons;Secure;Skin;skin disorder;Societies;success;symposium;synergism;Testing;Time;Training;Translating;Translational Research;United States;United States National Institutes of Health;Wages;Writing

PROJECT_TITLE: SID Retreat

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Epilepsy;Neurodegenerative;Neurosciences;Pain Research

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Understanding the basic mechanisms that control the excitability of central neurons will help in understanding the normal function of the nervous system as well as pathophysiology resulting in pain, epilepsy, ataxia, and other disorders. The work will specifically explore novel ways to differentially inhibit neuronal activity associated with pain and epilepsy while preserving other neuronal functions, by finding agents that inhibit or enhance specific ion channels with differential expression in different kinds of neurons.

PI_NAMEs: BEAN, BRUCE P (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Accidents;Action Potentials;Ataxia;Behavior;Calcium Channel;cell type;Clinical;Complex;Dependence;design;differential expression;Disease;drug action;Drug Targeting;Elements;Epilepsy;experience;Foundations;Functional disorder;Goals;Grant;hippocampal pyramidal neuron;Hippocampus;Individual;interest;Ion Channel;Knowledge;Laboratories;Membrane Potentials;Motor Neurons;Nervous System Physiology;neuronal patterning;Neurons;Nociceptors;novel;Pain;Pattern;Peptides;pharmacologic;Pharmacology;Population;Potassium Channel;preservation;rational design;Research;Role;Shapes;small molecule;Sodium Channel;Spinal Cord;targeted agent;Toxin;voltage;Work

PROJECT_TITLE: Ion Channel Pharmacology for Pain and Epilepsy


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Genetic Testing;Genetics;Human Genome;Lung;Rare Diseases

ORG_CITY: DANVILLE

ORG_NAME: GEISINGER CLINIC

PHR: Narrative: In the past, the medical community identified human diseases by combining patients with similar phenotypes and looking for shared genetic changes. This approach is limited by our clinical ability to see appropriate connections between phenotypic features in patients. This application uses a gene-first approach in a large research cohort with associated exome sequences to identify the full range of medically relevant human phenotypes (common and rare) associated with variants in genes coding for elastic fiber proteins followed by deep phenotyping in individual patients to learn more about the mechanism of disease and its clinical impact.

PI_NAMEs: BOEHM, MANFRED ;WILLIAMS, MARC S. (contact)

PROGRAM_OFFICER_NAME: OLIVE, MICHELLE

PROJECT_TERMS: Address;Affect;Aneurysm;Aorta;Aortic Valve Stenosis;Area;arterial tortuosity;autosome;Awareness;Basic Science;Biological;Blood Vessels;burden of illness;C-terminal;Case Study;Cell Line;Characteristics;Chronic Obstructive Pulmonary Disease;Clinical;clinical application;clinical center;Clinical Data;clinical phenotype;Clinical Research;clinically relevant;Code;cohort;Collaborations;Communities;Community Health;comparison control;Connective Tissue;Connective Tissue Diseases;Cutis Laxa;Data;Defect;Diagnosis;Diameter;Disease;disease model;Doctor of Philosophy;Elastic Fiber;Elastic Tissue;Elasticity;Elastin;Electronic Health Record;electronic structure;Ensure;exome;exome sequencing;experience;Extramural Activities;Family;Family history of;FBLN5 gene;Fibroblasts;fibulin-4;Frequencies;Functional disorder;General Population;Genes;Genetic;genetic pedigree;Genetic study;genetic testing;genetic variant;Genetic Variation;genomic data;Genomic medicine;Genomics;Genotype;Goals;Health;Health system;Human;human disease;Hypertension;Iceberg;improved;In Vitro;in vitro Model;Individual;individual patient;induced pluripotent stem cell;innovation;insight;Institute of Medicine (U.S.);Institution;interest;Intracranial Aneurysm;Investigation;Laboratories;Lead;Leadership;Learning;Link;Literature;Lung;Lung Diseases;Mediating;Medical;Medical Records;Methods;Mining;multidisciplinary;Mutation;novel;novel strategies;Online Mendelian Inheritance In Man;Participant;participant enrollment;Pathogenicity;Patients;Penetrance;Phenotype;phenotypic data;Physicians;Population;population based;premature;profiles in patients;protein function;protein structure;Protein-Lysine 6-Oxidase;Proteins;Publishing;Pulmonary Emphysema;Rare Diseases;rare variant;Recording of previous events;Records;Research;Research Personnel;Research Project Grants;Sampling;Skin;Stretching;success;System;text searching;Tissues;Translational Research;Translations;treatment strategy;United States National Institutes of Health;Variant;variant of interest;Work

PROJECT_TITLE: Collaborative Research to Explore Genetic Variation and Phenotypic Spectrum of Elastin and Related Genes