NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: CENTUORI, SARA M. (contact)

PROJECT_TERMS: Applications Grants;Area;Arizona;Artificial Intelligence;Basic Science;biobank;Biological Assay;cancer cell;Cancer Center;Cancer Center Support Grant;Cell Separation;Cellular biology;Certification;Clinical;Clinical Trials;Collaborations;Collection;Color;Communities;Computer software;Consultations;cost effective;Cryopreservation;Custom;Data Analyses;design;Development;Dissociation;Doctor of Philosophy;Education;Energy Metabolism;Equipment;Evaluation;experience;Experimental Designs;Extramural Activities;Flow Cytometry;Flow Cytometry Shared Resource;Funding;Future;Genus Hippocampus;Goals;Grant;Head and Neck Cancer;high resolution imaging;high standard;Human;Image;Imagery;Immune;Immune response;Immunologic Monitoring;Immunology procedure;innovation;innovative technologies;insight;instrument;instrumentation;International;Knowledge;Laboratories;Lasers;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;medical specialties;member;Microscopy;Monitor;multiple omics;Mus;Names;NCI Center for Cancer Research;new technology;novel;particle;Peer Review;Pharmacologic Substance;Phenotype;Population;primary endpoint;Primary Neoplasm;programs;Publications;quality assurance;Quality Control;Reagent;Research Personnel;Resource Sharing;Resources;response;Sampling;secondary endpoint;Services;Site;Speed;Stains;synergism;System;Techniques;Technology;Time;Tissues;Training;translational cancer research;Translational Research;Universities;Vision

PROJECT_TITLE: Flow Cytometry and Immune Monitoring Shared Resource (FCIMSR)


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Data Science;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANESTHESIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Postoperative Pulmonary Complications are common, costly and drivers of major inpatient morbidity. While risk models predict patients who may be at risk, few evidenced based management strategies exist, this approach has not been updated in light of the wealth of EHR derived data now available in contemporary practice. This study will apply data science to precisely define patient risk and identify modifiable care practices which would from the basis of interventions to reduce risk.

PI_NAMEs: COLQUHOUN, DOUGLAS ALASTAIR (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Affect;Anesthesia procedures;Anesthesiology;Board Certification;career;career development;Caring;Clinical;clinical practice;clinically relevant;cohort;Communication;Competence;Complex;Complication;Computer software;Computerized Medical Record;Consent;cost;Critical Care;Data;data complexity;data modeling;Data Science;data streams;Decision Making;Derivation procedure;Development;Electronic Health Record;Elements;Event;evidence base;Evidence based intervention;Goals;Grant;high dimensionality;high risk;Hospital Costs;Hospitals;Hypoxemia;improved;individual patient;Induction of neuromuscular blockade;Information Systems;innovation;inpatient surgery;Inpatients;insight;Institution;International;interoperability;Intervention;Intraoperative Care;Intraoperative Period;Intubation;Knowledge;Learning;Length of Stay;Life;Light;Liquid substance;Lung;Machine Learning;Mechanical ventilation;Medicine;Mentors;Michigan;minimally invasive;Modernization;Monitor;Morbidity - disease rate;mortality;Myocardial Infarction;myocardial injury;Observational Study;Operating Rooms;Operative Surgical Procedures;Opioid;Outcome;Patient Care;patient registry;patient response;Patient risk;Patients;Patterns of Care;Perioperative;Perioperative Care;Physiological;Physiology;Pneumonia;point of care;Population;Postoperative Complications;Postoperative Period;predictive tools;Preoperative Procedure;prevent;Prevention;Private Hospitals;Procedures;Process;professor;Provider;Recording of previous events;Records;Registries;Reporting;Research;Research Personnel;Research Training;Resources;Risk;Risk Estimate;Risk Factors;risk prediction;risk prediction model;Risk Reduction;Scientist;Series;Site;skills;Statistical Models;Structure;supervised learning;Surgical complication;Techniques;tenure track;Time;Training;Transfusion;Translating;Universities;Update;Variant;Ventilator;vigilance;Work

PROJECT_TITLE: Data Driven Approaches to Improving Risk Prediction of Pulmonary Complications After Major Inpatient Surgery

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Chronic Pain;Dental, Oral, and Craniofacial Disease;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative: The proposed research will elucidate the roles of thermal K2P channels in controlling trigeminal nociception and their dysfunction as a mechanism underlying trigeminal neuropathic pain. This is highly relevant to public health because it will provide new and important molecular insights into trigeminal neuropathic pain and identify thermal K2P channels as effective therapeutic targets for treating these debilitating pain disorders in patients.

PI_NAMEs: GU, JIANGUO  (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: afferent nerve;Air;allodynia;Animal Model;Chronic;Data;debilitating pain;design;Disease;Down-Regulation;experimental study;Face;Functional disorder;genetic approach;Genetic Enhancement;Goals;High Prevalence;Hyperalgesia;Immunohistochemistry;Impairment;In Situ;Injury;insight;Ion Channel;Mediating;Modeling;Molecular;Nerve;nerve injury;Neuropathy;new therapeutic target;Nociception;Nociceptors;Opioid;orofacial;oxaliplatin;Pain;Pain Disorder;painful neuropathy;patch clamp;Patients;pharmacologic;Physiological;Play;Potassium Channel;potassium channel protein TREK-1;prevent;Public Health;Publishing;Rattus;Research;Role;Structure of trigeminal ganglion;Suicide;Temperature;Testing;therapeutic target;therapeutically effective;tool;TRAAK channel;Trigeminal Nerve Diseases;Trigeminal nerve structure;Trigeminal Neuralgia;Trigeminal System;Voltage-Gated Potassium Channel;warm temperature;Weather

PROJECT_TITLE: Mechanism of Nociception Induced by Innocuous Cold in Trigeminal System

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prevention

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PI_NAMEs: ZAVROS, YANA  (contact)

PROJECT_TERMS: 3-Dimensional;animal tissue;anti-cancer research;Arizona;biobank;Biological Markers;Cancer Center;Cancer Center Support Grant;cancer therapy;Cells;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Collection;comorbidity;Coupled;Development;digital;Dimensions;Disease;Disease Progression;DNA Sequence Alteration;Doctor of Philosophy;drug discovery;Early Diagnosis;Early treatment;Education;epigenome;Fostering;Frozen Sections;Funding;Gender;Generations;Genes;Genome;Goals;Grant;Health Services Research;Hematoxylin and Eosin Staining Method;Histology;Human;human disease;human tissue;Image;Immune;Implant;Individual;innovation;insight;instrumentation;Laboratories;Life Style;Malignant Neoplasms;member;Methods;microbiome;Microscopy;Molecular Analysis;molecular targeted therapies;Morphology;mouse model;Mutation;novel therapeutics;Organoids;Paraffin Embedding;Pathology;Patients;personalized approach;personalized cancer therapy;Pre-Clinical Model;Prevention;Process;Protocols documentation;Publications;Research;Research Design;Research Personnel;Resource Sharing;Resources;Sampling;Services;Signal Pathway;Special needs;specific biomarkers;Specimen;Stains;targeted biomarker;targeted treatment;Technology;Testing;Therapeutic;three dimensional cell culture;Three-dimensional analysis;Tissue Banks;Tissue Sample;Tissues;tool;Training;Translational Research;treatment response;tumor;Universities;University resources

PROJECT_TITLE: Tissue Acquisition And Cellular/Molecular Analysis Shared Resource (TACMASR)


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: Overall Public Health Relevance  Cochlear neural degeneration (CND) is the loss of nerve connections between the sensory cells and the brain, which occurs in noise-damaged and aging ears. Although not detected by the threshold audiogram, this nerve damage is likely a major contributor to difficulties understanding speech in a noisy environment and may also instigate changes resulting in tinnitus and hyperacusis. Our Research Center aims to understand the prevalence of cochlear synaptopathy, measure/infer its consequences to suprathreshold sound processing, and to identify diagnostic markers. Therapies to reconnect nerves and sensory cells are on the horizon, and proper diagnostics are key to the design of clinical trials. The results are important to the public health, because noise- and ototoxic drug exposures may be damaging the ear well before the effects are seen in the threshold audiogram.

PI_NAMEs: KUJAWA, SHARON G (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acceleration;Acoustic Nerve;Acoustics;Afferent Neurons;Aging;Aminoglycosides;Animal Model;Animals;Audiology;Auditory;Autopsy;Behavioral;Behavioral Assay;behavioral study;Bilateral;Biological Assay;Biological Markers;Brain;cell injury;Cells;Cisplatin;Clinical;clinical application;Clinical Trials;Clinical Trials Design;Cochlea;cochlear synaptopathy;collaborative approach;Databases;Denervation;design;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic strategy;Diagnostic tests;diagnostic value;Disease;Disinhibition;Drug Exposure;Ear;Electrophysiology (science);Elements;Environment;Etiology;Exposure to;Frequencies;Generations;Hair Cells;handicapping condition;Hearing;hearing impairment;Hearing problem;Hearing Tests;Human;human subject;Hyperactivity;Hyperacusis;Individual;Injury;Inner Hair Cells;insight;Laboratories;Labyrinth;Life Style;Loudness Perception;Maps;Measurement;Measures;Mediation;Meniere's Disease;Mus;Nerve;nerve damage;Nerve Degeneration;Nerve Fibers;neural;Neurons;Neurophysiology - biologic function;Neurosciences;Noise;noise exposure;Noise-Induced Hearing Loss;normal aging;ototoxicity;Outer Hair Cells;Pathway interactions;Patients;Pattern;Perceptual Disorders;Performance;Peripheral;Persons;Pharmaceutical Preparations;Physiological;Population;Presbycusis;Prevalence;Psychophysics;Public Health;public health relevance;Recording of previous events;Records;regenerative therapy;Research;Risk Factors;Role;Sensorineural Hearing Loss;Sensory;sound;Specialized Center;Speech;Speech Discrimination;speech in noise;speech recognition;Statistical Models;statistics;Study Subject;Synapses;Testing;Tinnitus;Work

PROJECT_TITLE: Cochlear Synaptopathy: Prevalence, Diagnosis and Functional Consequences


PHR: Administrative Core Project Narrative  This P50 Research Center is focused on enhancing our understanding of the prevalence, diagnosis and functional consequences of nerve damage in the inner ear. This Administrative Core is designed to oversee all the research components of the Center, foster collaboration both within and outside of the Center, manage all the budgets, and interact with research administrators at the home institution and the NIH.

PROJECT_TERMS: Address;Administrator;Advisory Committees;Award;Biometry;Budgets;cochlear synaptopathy;Collaborations;conflict resolution;design;Diagnosis;Ear;Engineering;Ensure;Equity;Expenditure;Eye;Fostering;Future;Goals;Grant;Histology;Home;Human;Image;Institution;Labyrinth;Leadership;meetings;member;nerve damage;operation;Operations Research;Operative Surgical Procedures;Patients;Prevalence;Productivity;programs;Recording of previous events;Research;Research Personnel;Resource Sharing;Resources;Running;Schedule;Senior Scientist;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lung;Microbiome;Organ Transplantation;Transplantation

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE: This project will investigate the role of lung microbial dysbiosis and its effects on chronic rejection in lung transplant rejection.

PI_NAMEs: SHARMA, NIRMAL S (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acceleration;adjudication;Attenuated;attenuation;Autophagocytosis;Bacteroidetes;BCL2 gene;biological adaptation to stress;Biological Markers;Biopsy Specimen;bronchial epithelium;Bronchiolitis;Bronchoalveolar Lavage;Chronic;chronic inflammatory disease;Chronic Obstructive Pulmonary Disease;Coculture Techniques;cohort;curative treatments;Cystic Fibrosis;Data;dysbiosis;Epithelial Cells;epithelial injury;Epithelium;Exposure to;Fibroblasts;fibrogenesis;Fibrosis;Firmicutes;Functional disorder;Gelatinase B;Goals;Graft Rejection;gut dysbiosis;Homeostasis;Human;idiopathic pulmonary fibrosis;Impairment;improved;In Vitro;in vivo;inhibition of autophagy;intraperitoneal;Knock-out;Knowledge;Link;Longitudinal Studies;loss of function;Lung;lung allograft;Lung Diseases;lung microbiome;Lung Transplantation;Lymphocyte;machine learning algorithm;Measures;Mediating;microbial;microbial signature;microbiome;microbiome signature;microbiota;Modeling;mouse model;Mus;novel;Organ Transplantation;Pathogenesis;Pathogenicity;Patient-Focused Outcomes;post-transplant;Predisposition;Prevotella melaninogenica;profibrotic cytokine;Proteins;Proteobacteria;Pseudomonas aeruginosa;Pulmonary Hypertension;receptor;Regulation;respiratory;respiratory microbiome;respiratory pathogen;response;Risk;Role;rRNA Genes;Solid;spatiotemporal;Specimen;Streptococcus pneumoniae;Syndrome;Testing;Therapeutic;TLR4 gene;Toll-like receptors;Transforming Growth Factor beta;transplant model;Transplant Recipients

PROJECT_TITLE: Microbial Dysbiosis in Chronic Lung Allograft Dysfunction

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Hearing Loss;Neurodegenerative;Neurosciences

PHR: Project 1 Narrative – Public Health Relevance  Sensorineural hearing loss can be caused by overexposure to noise, certain ototoxic drugs as well as the aging process itself. Each of these can permanently damage the sensory cells and neurons of the inner ear and lead to problems hearing in noise as well as perceptual anomalies such as tinnitus or hypersensitivity to sound. Here, we use animal models to study the relations between well-characterized patterns of cellular damage and hearing outcomes to refine diagnostic tools for use in human subjects. Such refined diagnostics are increasingly critical as therapeutic approaches to the repair of inner ear damage are coming to clinical trials.

PROJECT_TERMS: Acceleration;Acoustic Nerve;Action Potentials;Acute;Affect;Aging;aging process;Aminoglycosides;Amplifiers;Animal Experiments;Animal Model;Animals;Auditory;auditory pathway;Auditory Perception;behavior measurement;behavior prediction;Behavioral;Behavioral Assay;behavioral outcome;Biological Assay;Biological Markers;cell injury;Cell Physiology;Cells;Chronic;Clinical Trials;Cochlea;Cochlear Nerve;cochlear synaptopathy;design;Diagnosis;Diagnostic;diagnostic tool;diagnostic value;Disabling;Disinhibition;Electrophysiology (science);Environment;Etiology;Exposure to;Fiber;Functional disorder;Gene Expression Profile;Hair Cells;Hearing;hearing impairment;Hearing problem;hearing range;Hearing Tests;Histologic;Histopathology;Human;human subject;Hyperactivity;Hyperacusis;Hypersensitivity;improved;Injury;Inner Hair Cells;Labyrinth;Lesion;Light;Linear Regressions;Link;Loudness;Loudness Perception;Measures;Modeling;mouse model;Mus;Nerve Degeneration;Nerve Fibers;neural;neural patterning;Neurons;Noise;normal hearing;novel;novel strategies;ototoxicity;Ouabain;Outcome;Outer Hair Cells;Pattern;Peptide Initiation Factors;Performance;Peripheral;Pharmaceutical Preparations;Phase;Physiological;postsynaptic;Prevalence;Protocols documentation;Psychophysics;public health relevance;receptor;Regression Analysis;repaired;Resolution;response;Role;round window;Sensorineural Hearing Loss;Sensory;sound;Specialized Center;Speech Discrimination;speech in noise;Stimulus;Synapses;Synaptic Potentials;Testing;Therapeutic;Tinnitus;Work

PROJECT_TITLE: Cochlear synaptopathy, neural pathophysiology and suprathreshold processing in animal models of sensorineural hearing loss


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Data Science;Hearing Loss;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rehabilitation

PHR: Project 2 Public Health Relevance  The ear damage that underlies the hearing impairments cannot be imaged in living humans. The only way to reveal the patterns of cellular degeneration is by the evaluation of autopsy specimens. This Project will determine the extent of damage to nerve fibers and sensory cells in the inner ears of patients with several of the most common forms of acquired hearing loss. Since therapeutics to regenerate nerves and sensory cells in a damaged inner ear are on the horizon, understanding the damage patterns, and how they relate to the audiometric profiles in the same patients, is key to diagnosis and the selection of subjects for clinical trials.

PI_NAMEs: LIBERMAN, M. CHARLES (contact)

PROJECT_TERMS: Acceleration;Acoustic Nerve;Acquired Deafness;Age;age related;Aminoglycosides;animal data;Animal Model;Antibiotics;Archives;Atrophic;Audiology;Auditory Threshold;Autopsy;Axon;Big Data;Biopsy;Case Study;cell injury;cell type;Cells;chemotherapy;Cisplatin;Clinical;clinical imaging;Clinical Trials;Cochlea;Cochlear Implants;cochlear synaptopathy;Collection;Complex;Data;data acquisition;Databases;deafness;Derivation procedure;Diagnosis;Ear;Etiology;Evaluation;Eye;Formulation;Foundations;ganglion cell;Generations;Grant;Hair Cells;hearing impairment;Hearing Tests;Histologic;Human;Hyperacusis;Image;inclusion criteria;Inner Hair Cells;insight;K ATPase;Labyrinth;Left;Literature;Location;Machine Learning;Measures;Meniere's Disease;Microscopic;Modeling;Nerve Degeneration;Nerve Fibers;Nerve Regeneration;neural;Neurons;noise exposure;normal aging;novel;ototoxicity;Pathology;Patients;Pattern;Peripheral;Platinum;Presbycusis;Prevalence;public health relevance;Publishing;rat Pres protein;Recording of previous events;Records;repaired;Resolution;Retrospective Studies;Risk Factors;Role;Sampling;Sensorineural Hearing Loss;Sensory;sex;Specimen;Speech;Speech Discrimination;Speed;spiral ganglion;Statistical Models;Stimulus;Subjects Selections;Synapses;Temporal bone structure;Testing;Therapeutic;Tinnitus;tissue resource;Toxic effect;Typology;Work

PROJECT_TITLE: Cochlear synaptopathy and audiometric measures from human temporal-bone cases of sensorineural hearing loss


ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Our Program Project will develop an integrated engineering approach to de-risk emerging immunotherapies during their pre-clinical development and direct them toward the patient populations that stand to benefit the most. This will allow the field to potentially move past historic 5% cancer therapy trial success rates so that more cancer patients benefit from immunotherapy sooner with less risk and at lower cost.

PI_NAMEs: LARGAESPADA, DAVID ANDREW;MASOPUST, DAVID ;ODDE, DAVID J. (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Acceleration;Accounting;anti-tumor immune response;Antitumor Response;Apoptosis;Area;Benefits and Risks;Biomedical Engineering;biophysical model;Biophysics;Blood;cancer cell;Cancer Control;Cancer Patient;Cancer Prognosis;cancer therapy;CAR T cell therapy;cell motility;Cells;Chemicals;Clinical;clinical risk;Clinical Trials;Collaborations;Complex;computational platform;Computers;cost;Cytoskeleton;cytotoxic;Development;Diagnosis;Economics;Effectiveness;engineered T cells;Engineering;Environment;exhaustion;Explosion;Failure;Genetic;Genetic Engineering;Genetically Engineered Mouse;Genome engineering;Glioblastoma;Growth;Health Benefit;high resolution imaging;high risk;Image;Immune;immune cell infiltrate;Immune response;Immune system;Immunocompetent;immunoengineering;Immunologics;Immunologist;Immunooncology;Immunotherapeutic agent;Immunotherapy;immunotherapy clinical trials;improved;In Vitro;in vivo;Liquid substance;live cell microscopy;Malignant neoplasm of brain;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mechanics;Microfabrication;model development;Modeling;models and simulation;nanoscale;Oncology;optical imaging;optimism;Pancreatic Ductal Adenocarcinoma;patient population;Patients;pharmacologic;Phase;physical science;Physics;Plants;pre-clinical assessment;pre-clinical research;preclinical development;Process;Prognosis;programs;Proliferating;response;Risk;Signal Transduction;Solid Neoplasm;Stream;success;System;T-Lymphocyte;Technology;Testing;Therapy trial;Time;Tissues;Translations;tumor;tumor immunology;tumor progression;Tumor-infiltrating immune cells

PROJECT_TITLE: Integrated Immune Engineering for Poor Prognosis Cancers


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

PHR: NARRATIVE: PROJECT 1 Brain tumors remain among the most malignant and deadly cancers, with adult glioblastoma (GBM) patients having a median survival of 15 months and five-year survival of less than 10 percent. We aim to use new and innovative simulation tools to better screen GBM immunotherapies before they reach clinical trials. We will also use these simulators to develop and test immunotherapies in mouse GBM models.

PI_NAMEs: ODDE, DAVID J. (contact)

PROJECT_TERMS: Adult Glioblastoma;Anisotropy;anti-tumor immune response;Apoptosis;Brain;Brain Neoplasms;brain tissue;cancer cell;Cancer Prognosis;CD 200;cell killing;cell motility;Cells;Cessation of life;Chemotaxis;chemotherapy;Clinical;clinical risk;Clinical Trials;clinically actionable;combinatorial;computational platform;computer framework;confocal imaging;cytokine;Cytotoxic agent;Data;Development;digital;Dissociation;engineered T cells;Engineering;Environment;Exclusion Criteria;exhaustion;experience;experimental study;Failure;Flu virus;Fluorescence Microscopy;Frequencies;Genetically Engineered Mouse;Genome engineering;genome-wide;Glioblastoma;Glioma;Human;human disease;Immune;Immune response;Immunocompetent;immunoengineering;Immunologic Stimulation;Immunologics;Immunosuppression;Immunotherapy;immunotherapy trials;In Vitro;in vivo;Infiltration;innovation;insight;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Mechanics;Mediating;Mesenchymal;Microscopy;migration;Modeling;mouse model;multi-scale modeling;Mus;neoplasm immunotherapy;neoplastic cell;novel therapeutic intervention;Oncogenic;Operative Surgical Procedures;Optics;Outcome;outcome prediction;patient stratification;Patients;Peptides;Pharmaceutical Preparations;Phenotype;Positioning Attribute;Prognosis;Proliferating;Publishing;Radiation;receptor;simulation;Sleeping Beauty;Slice;Solid Neoplasm;standard of care;success;T-Lymphocyte;Testing;Therapeutic;tool;Traction;transcriptomics;Translating;tumor;tumor progression;Two-Parameter Model;two-photon;unpublished works;Vaccination;Vaccines

PROJECT_TITLE: Project 1


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Hearing Loss;Neurodegenerative;Neurosciences;Rehabilitation

PHR: Project 3 Public Health Relevance – Project Narrative Tinnitus, reduced sound level tolerance and difficulty understanding speech in noisy backgrounds are the most common complaints associated with age-related hearing loss, the most prevalent type of sensorineural hearing loss in adult populations. This proposal aims to identify biomarkers of cochlear neural degeneration that can be associated with these common hearing complaints. This research will help identify candidates and track the efficacy of emerging treatments meant to 1) provide better speech intelligibility outcomes to hearing aid users, 2) shed a new light on strategies to silence tinnitus and 3) reduce the physiological activity leading to hyperacusis.

PI_NAMEs: MAISON, STÉPHANE F. (contact)

PROJECT_TERMS: Accounting;Acoustic Nerve;Adult;Affective;analog;Animal Model;Animals;Auditory;auditory processing;Auditory system;Behavioral;Biological Assay;Biological Markers;biomarker identification;Brain Stem;candidate identification;Cell Death;Cell Physiology;cellular pathology;Central Nervous System;Characteristics;Chronic;Cochlea;cochlear synaptopathy;cognitive function;Development;Diagnosis;Disease;ear muscle;Electrocochleographies;Environment;Frequencies;Future;Grant;Hair Cells;Hearing;Hearing Aids;hearing impairment;Hearing problem;Hearing Tests;Histopathology;Human;Hyperactivity;Hyperacusis;Hypersensitivity;Impairment;Inner Hair Cells;Labyrinth;Light;Location;Loudness;Maintenance;Maps;Measures;Medial;Meniere's Disease;middle ear;Nerve Degeneration;Nerve Fibers;neural;Neurologic Symptoms;Noise;normal aging;normal hearing;otoacoustic emission;Outcome;Outcome Measure;outcome prediction;Outer Hair Cells;Participant;Patient Recruitments;Patients;Pattern;Performance;Peripheral;Physiological;Population;Presbycusis;Prevalence;Psychoacoustics;Psychophysics;public health relevance;Questionnaires;Reflex action;Regression Analysis;repaired;Reporting;Research;Residual state;response;Role;Secondary to;Sensorineural Hearing Loss;Sensory;Series;Severities;sex;sound;Speech;Speech Intelligibility;Statistical Models;Subjective Tinnitus;Synapses;Temporal bone structure;Testing;Therapeutic;therapy design;Time;Tinnitus;Traction;Vertigo;Visual

PROJECT_TITLE: Biomarkers of cochlear synaptopathy and their relation to suprathreshold hearing disorders in humans with sensorineural hearing loss


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project will follow participants from two randomized trials to evaluate the impact of the REDI-Classroom and REDI-Parent Head Start enrichment programs on the late adolescent and early adult outcomes of children who attended Head Start. Benefits in areas of educational attainment, employment, health, and reduced risky behavior (antisocial behavior, substance abuse, and risky sexual behavior) will be evaluated with self-reports, parent reports, teacher reports, and administrative data review. The project will contribute to public health by evaluating the long-term impact and mechanisms of action of preschool enhancements that aim to improve the educational attainment, productivity, and health of children growing up in low-income families.

PI_NAMEs: BIERMAN, KAREN L (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 4 year old;Academic achievement;Address;administrative database;Adolescence;Adolescent;Adolescent Behavior;Adult;Affect;Age;antisocial behavior;Area;care systems;Child;Child Health;Childhood;comparison group;Competence;Control Groups;Cost Analysis;cost comparison;cost effectiveness;cost estimate;Costs and Benefits;Criminal Justice;Data;Data Collection;Data Management Resources;Data Reporting;Databases;Development;Disparity;early childhood;economic evaluation;Economics;Education;Educational Curriculum;Educational Intervention;elementary school;emerging adult;emotion regulation;Emotional;emotional functioning;Employment;executive function;experience;Face;fifth grade;Financial cost;follow up assessment;Follow-Up Studies;Funding;Future;Goals;Graduation Rates;group intervention;Head Start Program;Health;Health Services;high risk sexual behavior;high school;Home visitation;improved;incremental cost-effectiveness;Individual;Informal Social Control;interest;Intervention;intervention effect;Interview;Investments;Language;learning engagement;learning materials;Life;Link;literacy;Longitudinal Studies;Longterm Follow-up;lower income families;Measurement;Measures;Mediation;Mental Health;Modeling;ninth grade;Nursery Schools;Outcome;parenting intervention;Parents;Participant;patient home care;Patient Self-Report;Performance;Personal Satisfaction;Policies;Preschool Child;Productivity;programs;Public Assistance;Public Health;Randomized;randomized trial;Readiness;Records;recruit;relative cost;Reporting;Research;Risk;Risk Behaviors;Sampling;Schools;self-directed learning;service utilization;Services;Sex Behavior;skills;social;social disparities;social skills;Social Work;Societies;socioeconomics;Substance abuse problem;substance use;success;Surveys;teacher;therapy design;Time;Universities;Work;young adult

PROJECT_TITLE: Head Start REDI Classroom and Home Visiting Programs: Long-Term Follow-up

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Hearing Loss;Neurodegenerative;Neurosciences

PHR: Project 4 – Project Narrative Difficulty hearing in background noise, tinnitus (ringing of the ears), and hyperacusis (auditory hypersensitivity and discomfort) are linked to noise exposure, aging, and hearing loss, but the connection between these risk factors and any particular set of hearing complaints is obscure. Here, we will measure intermediate layers of sound processing in the human nervous system that more directly underlie these common hearing complaints. This research will advance our understanding of the biological causes for these hearing disorders and will promote new approaches for their objective clinical measurement and treatment.

PI_NAMEs: POLLEY, DANIEL B. (contact)

PROJECT_TERMS: Adult;Affective;Afferent Neurons;Age;Aging;Animal Experimentation;Animals;Area;arm;Arousal;assault;Auditory;auditory pathway;Auditory Perception;auditory processing;Auditory Threshold;Awareness;Behavior assessment;Behavioral;behavioral outcome;behavioral phenotyping;Biological;Biological Markers;Brain;Categories;Clinical;Cochlea;cochlear synaptopathy;Code;cognitive load;Consensus;Coupling;Cues;Data;Diagnosis;Diameter;Digit structure;Disease;Disinhibition;Distress;Ear;Electroencephalography;Emotional;Equilibrium;Exhibits;experience;Face;Facial Expression;Functional disorder;Galvanic Skin Response;Grant;Growth;Hearing;hearing impairment;Hearing problem;Heart Rate;Human;human subject;Hyperactivity;Hyperacusis;Hypersensitivity;improved;Individual;innovation;Laboratories;Link;Loudness;Maps;Measurement;Measures;Mediation;Mydriasis;Nerve Degeneration;Nervous System;neural;Neurons;Noise;noise exposure;normal hearing;novel;novel strategies;older adult;Older Population;Outcome;Pain;Peptide Initiation Factors;Perception;Perceptual Disorders;Peripheral;Persons;Phenotype;Physiological;Prevalence;Process;Process Assessment;Protocols documentation;Psychoacoustics;Psychophysics;Publishing;Pupil;Questionnaires;Randomized, Controlled Trials;Recording of previous events;recruit;Research;Research Priority;response;Risk Factors;Sensorineural Hearing Loss;Sensory;Series;sound;Source;speech in noise;Speech Intelligibility;Speech Perception;Stimulus;Structure;Testing;Tinnitus;Training;Work

PROJECT_TITLE: Maladaptive central plasticity and suprathreshold hearing disorders in humans with sensorineural hearing loss and their relation to biomarkers of cochlear synaptopathy


NIH_SPENDING_CATS: Pediatric

ORG_CITY: KANSAS CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: The Greenwald Symposium brings together established scientists and young investigators-in-training to discuss new findings in the fields of reproduction, development, and maternal health. The Symposium functions to further the progress of science and medicine in these focus areas. The Symposium further enhances the training of young investigators.

PI_NAMEs: ROBY, KATHERINE F (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Address;Area;Award;Awareness;Basic Science;career;career networking;Clinical Sciences;Collaborations;Communication;cost;Development;Disease;diversity and inclusion;Doctor of Philosophy;Education;Elevator;Ensure;Epigenetic Process;experience;Exposure to;Faculty;Feedback;Financial Support;Fostering;Future;Genetic;Goals;improved;Individual;Institution;interest;Iowa;Kansas;Knowledge;Laboratories;Life;Maternal Health;Medical center;Medicine;meetings;Midwestern United States;Missouri;Nebraska;Network Infrastructure;Oral;Participant;Pathology;Perinatal;Postdoctoral Fellow;posters;Process;programs;regenerative;Regenerative Medicine;Reproduction;reproductive;Reproductive Sciences;Reproductive system;Research;Research Personnel;Research Project Grants;Research Technics;Role;Science;Scientist;skills;stem cell biology;Students;symposium;Training;Travel;Underrepresented Populations;Universities;Visit;Work

PROJECT_TITLE: Gilbert S Greenwald Symposium on Reproduction and Perinatal Research

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD(R)-R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Prosthetic infection of metallic implants is one of the most serious complications in orthopedic surgeries, occurring in 1-4% of primary total joint replacement and up to 30% of revisions. Existing prophylactic antibiotic delivery involves high drug loading doses that are unsafe, ineffective and could lead to the development of drug resistance. The proposed metallic implant surface coating strategy enables on-demand release of covalently tethered antibiotics in a timely and sustained manner, bringing together safety and efficacy in addressing the daunting challenge of periprosthetic infections. Page 5

PI_NAMEs: SONG, JIE  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Animals;Antibiotics;aspirate;Bacteria;Biological Assay;bioluminescence imaging;bone;Bone Cements;Bypass;Characteristics;Chemicals;Clinical;clinical translation;clinically relevant;comparative efficacy;cortical bone;Debridement;Detection;Development;Dose;drug resistance development;efficacy evaluation;Engineering;Ensure;ethylene glycol;Evaluation;Femur;Goals;Growth;Histology;Hydrogels;Implant;implant associated infection;implant coating;improved;In Vitro;in vivo;in vivo evaluation;Incubated;Infection;Infection prevention;infection rate;Injections;Invaded;Location;Mechanics;metallicity;Methylation;microbial;Microbial Biofilms;Micrococcal Nuclease;Modeling;Modification;Monitor;Mus;nuclease;Nucleotides;Oligonucleotides;operation;Operative Surgical Procedures;Organ;Orthopedic Surgery;Orthopedics;Osteomyelitis;Pathology;Pharmaceutical Preparations;phosphodiester;phosphorothioate;Predisposition;prevent;prophylactic;Prosthesis;Prosthesis-Related Infections;Rattus;recurrent infection;Replacement Arthroplasty;Safety;Saline;Second Look Surgery;Serum;side effect;standard care;Staphylococcus aureus;Staphylococcus aureus infection;success;Surface;surface coating;Surgical Models;System;Systemic infection;Technology;Testing;Thick;Torsion;translational potential;Vancomycin

PROJECT_TITLE: Micrococcal nuclease-triggered antibiotics release: a prophylactic implant coating against S. aureus infections


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Hearing Loss;Networking and Information Technology R&D (NITRD);Neurosciences

PHR: Scientific Core – Narrative Public Health Relevance  Our P50 Clinical Research Center assembles a team of four clinician scientists and basic scientists to study the mechanisms underlying three of most vexing aspects of sensorineural hearing loss, i.e. problems understanding in a noisy environment, reduced tolerance for even moderate-level sounds, and the phantom sounds of tinnitus. The Scientific Core leverages the considerable additional expertise of the numerous other hearing and deafness researchers at the Eaton-Peabody Laboratories by tapping into the longstanding technical Research Cores of this group, that have long been sharing expertise and a technical support staff to push the collective research further and faster.

PROJECT_TERMS: 3-Dimensional;Acoustics;Animal Experiments;Animals;Area;Automation;Center Core Grants;Clinical Research;Cochlea;cochlear synaptopathy;Collaborations;commune;Communication;Communities;Computer software;computerized data processing;Consumption;Custom;data acquisition;deafness;design;Devices;Diagnosis;digital imaging;Discipline;Electronics;Encapsulated;Endowment;Engineering;Environment;experience;Fees;Funding;Future;Generations;Goals;Hearing;Histologic;Histology;Home;Human;Human Resources;Image;imaging software;Individual;Infrastructure;innovation;interdisciplinary collaboration;Joints;Knowledge;Laboratories;Leadership;Licensure;mechanical device;member;Microscope;morphometry;Mus;National Institute on Deafness and Other Communication Disorders;Nature;novel;novel strategies;Operative Surgical Procedures;Participant;Phase;Preparation;Prevalence;Productivity;Program Research Project Grants;programs;Protocols documentation;public health relevance;reconstruction;Recording of previous events;repository;Research;Research Personnel;Research Project Grants;Resources;Science;Scientist;Sensorineural Hearing Loss;Services;software systems;sound;Stimulus;Structure;success;System;Technical Expertise;Techniques;Technology;Time;Tinnitus;Training;United States National Institutes of Health;Wages;Writing

PROJECT_TITLE: Scientific Core


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Pediatric;Rheumatoid Arthritis

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE In adults and children, drug dosing for biologic agents do not account for the substantial physiologic alterations resulting from obesity. These changes may result in a high inflammatory state and can affect drug disposition, thereby leading to therapeutic failure, increased disease activity, and poor clinical outcomes. This proposal will systematically characterize disease activity and biologic agent disposition in obesity using advanced pharmacokinetic and pharmacodynamic modeling, and use the model to optimize dosing and improve outcomes in inflammatory arthritis.

PI_NAMEs: BALEVIC, STEPHEN JOSEPH (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Acceleration;Adult;adult obesity;Affect;Agreement;Applications Grants;Arthritis;Biological;Biological Markers;Biological Products;Blood;career;career development;Child;Childhood;Chronic Childhood Arthritis;Clinic;Clinical;Clinical Pharmacology;Clinical Research;Clinical Trials;Collaborations;Conduct Clinical Trials;cytokine;Data;Databases;design;Development Plans;disability;Disabling;Disease;Doctor of Philosophy;Dose;dose individualization;drug clearance;drug disposition;Drug Kinetics;Drug usage;educational atmosphere;Effectiveness;Enrollment;Etanercept;experience;Exposure to;Faculty;Failure;Foundations;Frequencies;Future;Goals;improved;improved outcome;Individual;Inflammation;Inflammatory;Inflammatory Arthritis;International;K-Series Research Career Programs;Knowledge;Lead;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Modeling;Non obese;North Carolina;novel strategies;obese patients;Obesity;obesity in children;Observational Study;Outcome;Pain;Participant;Patient Outcomes Assessments;Patients;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Pharmacology;Physicians;Physiological;Physiology;Population;prospective;Protocols documentation;Public Health;Publications;Recording of previous events;Registries;Research;Research Institute;Research Personnel;response;Rheumatism;Rheumatoid Arthritis;Rheumatology;Safety;Sampling;Science;Scientist;Site;skills;standard of care;Statistical Data Interpretation;Structure;success;Techniques;Therapeutic;Therapeutic Uses;TNF gene;tool;Training;Treatment Efficacy;Treatment Failure;treatment optimization;treatment response;trial design;Universities;validation studies;virtual

PROJECT_TITLE: Optimal Dosing for Biologic Agents in Obese Patients with Rheumatoid and Juvenile Arthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: NARRATIVE Pancreas cancer is an extremely lethal disease and is now the fourth leading cause of cancer- related mortality in this country. We propose a systematic and integrated program of investigation to elucidate how engineered T cells infiltrate and migrate through fibroinflammatory and refractory pancreas cancer. We will test promising strategies to further modify the T cells and/or the robust stromal response to inform next-generation cell-based immunotherapies that are safe and maximally effective for pancreas cancer patients.

PI_NAMEs: PROVENZANO, PAOLO  (contact)

PROJECT_TERMS: Actins;Adhesions;Adoptive Immunotherapy;antigen-specific T cells;Apoptosis;Architecture;Behavior;burden of illness;Cancer Etiology;Cancer Prognosis;CD44 gene;cell motility;Cells;cellular engineering;Cellular immunotherapy;Chemicals;chemokine;chemokine receptor;Clinical;cohort;Complex;Country;Coupled;CRISPR/Cas technology;CXC chemokine receptor 3;CXCR3 gene;CXCR4 gene;Cytoskeleton;design;Desmoplastic;Development;Disease;Disease Outcome;Drug Delivery Systems;Dynein ATPase;effector T cell;Elements;engineered T cells;Engineering;Environment;experimental study;Extracellular Matrix;Flow Cytometry;Genes;genetically modified cells;genome editing;Genome engineering;Goals;Halofuginone;humanized mouse;Hyaluronan;Image;Immune;immune cell infiltrate;immune checkpoint blockade;immunoengineering;Immunofluorescence Immunologic;Immunosuppression;Immunotherapy;improved;improved outcome;In Vitro;in vivo;Infiltration;Inflammation;Infusion procedures;innovation;Integrins;Intervention;intravital imaging;Investigation;KPC model;Longevity;Malignant Epithelial Cell;Malignant neoplasm of pancreas;Malignant Neoplasms;mathematical model;Measures;Mechanics;Memory;Microtubules;migration;Modeling;Molecular;mortality;Motor;multiphoton microscopy;Myosin ATPase;Neoplasm Metastasis;next generation;novel;Organoids;overexpression;pancreatic cancer patients;Pancreatic carcinoma;Pancreatic Ductal Adenocarcinoma;Phenotype;Population;pre-clinical;preclinical evaluation;Primary Neoplasm;programs;Proliferating;PTK2 gene;Radiation therapy;receptor binding;Refractory;Resistance;response;RUNX3 gene;Sampling;Slice;Solid Neoplasm;Source;spatiotemporal;success;Survival Rate;synergism;System;T cell infiltration;T cell therapy;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Tissues;transcription factor;Treatment Efficacy;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor Volume;Tumor-infiltrating immune cells

PROJECT_TITLE: Project 2


PHR: NARRATIVE: PROJECT 3 Immunotherapy advances have been successful against some leukemias, but largely ineffective for treating solid tumors. We aim to use new gene editing techniques to develop T cells that will track and attack brain and pancreatic tumors, two cancers with the worst survival rates. Furthermore, we aim to develop methods to produce these T cells rapidly and cost-effectively.

PI_NAMEs: MORIARITY, BRANDEN S (contact)

PROJECT_TERMS: activating transcription factor;Address;Affect;Animal Model;antigen test;base;base editing;base editor;Base Pairing;Binding Sites;Brain Neoplasms;cancer immunotherapy;Cancer Patient;Cancer Prognosis;CAR T cell therapy;CD19 gene;cell motility;Cell Physiology;Cell Therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;clinical translation;Collaborations;Complementary DNA;Complex;cost;Coupled;CRISPR/Cas technology;Data;digital;DNA;DNA Double Strand Break;DNA Sequence Alteration;effective therapy;engineered T cells;Engineering;ex vivo imaging;Family;Flow Cytometry;Gene Delivery;Gene Targeting;gene-editing approach;Genes;Genetically Engineered Mouse;genetically modified cells;genome editing;Genome engineering;genotoxicity;homologous recombination;Human;Human Engineering;Immunocompetent;immunoengineering;Immunotherapy;improved;in vitro testing;in vivo;innovation;interest;intravital imaging;Knock-in;Knock-out;knockout gene;Laboratories;lentivirally transduced;leukemia;leukemia treatment;live cell imaging;Malignant Neoplasms;mathematical model;Mechanics;Memory;mesothelin;Methods;migration;Modality;Modeling;mouse model;Mus;new technology;novel;NR4A1 gene;NR4A2 gene;nuclease;Outcome;overexpression;pancreatic cancer model;pancreatic neoplasm;Patients;Phenotype;pre-clinical;pre-clinical assessment;Pre-Clinical Model;Preclinical Testing;prime editing;Process;Prognosis;programmed cell death protein 1;promoter;Publishing;Recombinant adeno-associated virus (rAAV);repaired;Resolution;Risk;Safety;Site;Solid Neoplasm;success;Survival Rate;synergism;System;T-Cell Receptor;T-Lymphocyte;targeted nucleases;Technology;Testing;Therapeutic Uses;Three-Dimensional Imaging;transcription factor;tumor;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;Work

PROJECT_TITLE: Project 3


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Rare Diseases

PHR: NARRATIVE The Administrative Core will provide overall leadership and administrative support to this PPG. The Core will facilitate weekly meetings and semi-annual workshops, promote integration of the PPG projects, support translational activities that emerge from this PPG, and build a collaborative and innovative cancer immune- engineering community at the University of Minnesota.

PROJECT_TERMS: Acceleration;Award;Basic Science;Biomedical Engineering;Biophysics;Brain Neoplasms;Cancer Center;Cancer Prognosis;cell motility;Clinic;clinical translation;Collaborations;Communication;Communities;Computer Models;design;Development;Educational workshop;Engineering;Ensure;Evaluation;Event;experience;Faculty;Feedback;Funding;Genome engineering;Goals;Grant;Immune;immunoengineering;Immunologist;Immunology;Immunotherapy;improved;innovation;Institution;Knowledge;Leadership;Malignant Neoplasms;Medicine;meetings;member;Microbiology;Minnesota;mouse model;Oncology;physical science;pre-clinical therapy;Problem Solving;Procedures;professor;Program Development;programs;Recording of previous events;Research;Research Project Grants;Scientist;T cell response;T memory cell;T-Lymphocyte;therapy development;tool;Translations;tumor;tumor immunology;United States National Institutes of Health;Universities;Work


NIH_SPENDING_CATS: Genetics;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PHR: PROJECT NARRATIVE Rotator cuff tears (RCTs) that involve primarily the supraspinatus and infraspinatus shoulder tendons and muscles are among the most common debilitating shoulder injuries. While RCTs can be surgically repaired, the rate of retear is significant and has been correlated to pathological levels of rotator cuff muscle fatty infiltration, fibrosis, and muscle atrophy. In this application we identify a potentially important regulator of the RCT pathology and propose both genetic and pharmacologic approaches to delete/inhibit this signaling pathway, while also performing genetic reporter analysis, histology, IHC/IF, bulk-RNA sequencing, and sophisticated single cell RNA-sequencing assays in order to determine the detailed cellular and molecular mechanisms underlying the RCT pathology.

PI_NAMEs: HILTON, MATTHEW J. (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: ACTA1 gene;Adipocytes;Affect;Antibodies;Articular Range of Motion;Atrophic;Biological Assay;cell type;Cells;Clinical;clinically relevant;Contralateral;Data;Development;Effectiveness;Failure;Fatty acid glycerol esters;Fibroblasts;fibrogenesis;Fibrosis;Flow Cytometry;GDF11 gene;GDF8 gene;Gene Deletion;Gene Expression;Genes;Genetic;genetic approach;Genetic Models;Harvest;Heterogeneity;Histologic;Histology;Human;In Vitro;in vivo;Infiltration;infraspinatous muscle;injured;Injury;insight;Intramuscular;lipid biosynthesis;Mesenchymal;Minor;Modeling;Molecular;mouse genetics;mouse model;Mus;Muscle;Muscle Fibers;muscle regeneration;Muscle satellite cell;Muscular Atrophy;Nemaline Myopathies;neutralizing antibody;Oculopharyngeal Muscular Dystrophy;Operative Surgical Procedures;Outcome;Pathologic;Pathology;Pathway interactions;pharmacologic;Population;Population Heterogeneity;Prevalence;Prevention;progenitor;prophylactic;repaired;Reporter;Research;response;Role;Rotator Cuff;rotator cuff tear;Shoulder;shoulder injury;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Skeletal Muscle;Sorting;stem cell differentiation;stem cell expansion;Subcutaneous Injections;subscapularis muscle;supraspinatus muscle;Tamoxifen;Tendon structure;Testing;Therapeutic;transcriptome sequencing;translational therapeutics;Treatment Protocols;Upper arm;Validation;virtual;Wild Type Mouse;Work

PROJECT_TITLE: Genetic and Therapeutic Approaches to Alleviate the Pathology of Massive Rotator Cuff Tears

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-D (05)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Brain Disorders;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Health disparities in neuroscience and genomics are hindering the development of effective and equitable neurotherapeutics, and potentially increasing health disparities for neurological disorders. The proposed research project will identify and characterize genetic and epigenetic variation influencing ancestry differences in four postmortem brain regions. These findings will enhance our understanding of genetic variation in the human brain allowing for improved drug discovery models based on genetic ancestry, which would pave the way for equitable personalized medicine and take a much-needed step toward reducing health disparities in neuroscience and genomic research.

PI_NAMEs: BENJAMIN, KYNON JADE M (contact)

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: Address;Affect;African ancestry;Antipsychotic Agents;Autopsy;biological research;bisulfite sequencing;Brain;Brain Diseases;Brain region;brain tissue;career;career development;Career Transition Award;caudate nucleus;causal variant;cell type;Cells;cohort;Collaborations;Collection;Complex;Computer Analysis;Data;data integration;Data Set;dentate gyrus;Development;diagnostic accuracy;differential expression;Disease;Disease susceptibility;Disparity;DNA Methylation;drug discovery;Environment;Epigenetic Process;epigenetic variation;Equity;European ancestry;Exons;experience;experimental study;Explosion;fetal;follow-up;Future;Genes;Genetic;genetic analysis;Genetic Transcription;Genetic Variation;genomic data;Genomics;Genotype;Goals;Grant;health disparity;Heritability;Hippocampus;Human;Human Genetics;improved;indexing;Individual;Life;Link;Machine Learning;Maps;Mental disorders;Mental Health;Mentors;Mentorship;Methods;Methylation;Modeling;Nervous System Disorder;neurodevelopment;neuropsychiatric disorder;Neurosciences;personalized medicine;Phase;Play;Postdoctoral Fellow;postnatal;Prefrontal Cortex;prenatal;Quantitative Trait Loci;Reduce health disparities;Research;Research Personnel;Research Project Grants;Resource Development;response;Role;Sampling;Schizophrenia;skills;SNP array;Statistical Methods;success;Techniques;Testing;Training;trait;Transcript;transcriptome sequencing;Universities;Variant;whole genome;Work

PROJECT_TITLE: Comprehensive computational analysis of genetic and regulatory differences between individuals with African and European ancestries across four brain regions


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: NARRATIVE  Early and prolonged parent-child separation due to parental migration or immigration may result in attachment disruption that can threaten the long-term mental health and functioning of affected children, and these risks can persist following reunification and through adulthood. Although sending infants back to the home country for rearing is often practiced among Chinese immigrants, especially low-income families, research has been sparse in understanding the long-term impact of early and prolonged parent-child separation and reunification on disparities in mental health and functioning among separated-reunited children and the mechanism through which such relationships may operate. The proposed exploratory sequential mixed-methods research comprises 3 studies—(1) qualitative interviews with affected children and parents, (2) a quantitative survey, and (3) mixed-methods analysis—to understand the mental health impacts, risk/protective factors, and service needs among separated-reunited Chinese American children.

PI_NAMEs: SU, SHAOBING  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Adolescence;Adult;Affect;Age;aged;anti-Asian;Area;Asian Americans;Award;Back;Biological;Boston;Caregivers;Caucasians;Child;Child Care;Child Development;Child Mental Health;Child Rearing;Childhood;China;Chinese;Chinese American;cohort;college;Communities;community advisory board;community based participatory research;Compensation;Country;COVID-19 pandemic effects;Data;design;Development;Discrimination;Disparity;emotional adjustment;ethnic identity;ethnic minority;Ethnic Origin;experience;Extended Family;Face;Family;Foundations;Gender;Goals;Grant;health disparity;High Prevalence;Home;Immigrant;Immigration;improved;Individual;Infant;informant;Institution;Interpersonal Relations;Intervention;Intervention Studies;Interview;Knowledge;lens;Literature;Low income;lower income families;Measures;Mediating;meetings;mental development;Mental disorders;mental function;Mental Health;Mental health promotion;Mental Health Services;Methodology;Methods;Migrant;migration;Modeling;modifiable risk;New York City;Outcome;Parents;Participant;Phase;Policies;Positioning Attribute;preservation;primary caregiver;Process;protective factors;Psychological Stress;psychosocial;racial minority;Recording of previous events;Reporting;Research;Research Methodology;Research Personnel;resilience;Resources;Risk;Risk Factors;Role;Sampling;School-Age Population;Services;Shapes;skills;Specific qualifier value;Stress;Structure;Subgroup;Surveys;Testing;theories;Theory of Change;therapy development;Training;United States;Variant;Writing;Youth

PROJECT_TITLE: Effects of Early and Prolonged Parent-Child Separation: Understanding Mental Health among Separated-Reunited Chinese American Children


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: UNIVERSIDAD PERUANA CAYETANO HEREDIA

PHR: Project Narrative HIV disproportionally affects men who have sex with men, who report low retention in HIV care, which is associated with decreased survival, viral resistance, and HIV transmission. The World Health Organization strongly recommends mobile technologies to improve adherence; however, evidence on the role of mobile health for retention in HIV care is scarce. I will adapt the WelTel system, which has been proven to increase adherence to HIV treatment, in order to deliver a text messaging-based intervention and assess the efficacy to increase retention in HIV care among HIV+ gay men in Peru.

PI_NAMEs: MENACHO ALVIRIO, LUIS ALBERTO (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Adherence;Affect;AIDS prevention;antiretroviral therapy;Appointment;Area;arm;Award;Awareness;career;Caring;Cellular Phone;Clinic;Clinical;Cohort Studies;Collaborations;Communication;Continuity of Patient Care;cost effective;Country;Data;design;Diagnosis;effective intervention;effectiveness evaluation;Effectiveness of Interventions;efficacy evaluation;Enrollment;Epidemic;Epidemiologic Methods;Evaluation;experience;Fostering;Funding;Funding Mechanisms;Gays;General Population;global health;Goals;Government;Grant;Health;Health Personnel;Health Policy;HIV;HIV Infections;HIV prevention trial;HIV Seropositivity;Hospital Referrals;Hospitals;Human immunodeficiency virus test;implementation science;improved;Incidence;Infection;Institution;interest;International;Intervention;Intuition;K-Series Research Career Programs;Knowledge;Latin America;Link;Manuscripts;men;men who have sex with men;Mentors;Mentorship;Methods;mHealth;mobile computing;Monitor;Morbidity - disease rate;mortality;mortality risk;multi-site trial;multidisciplinary;novel;Outcome;Participant;Patient Self-Report;Patients;Persons;Peru;Peruvian;Population Group;Prevalence;Privatization;Provider;Qualitative Research;Quality of Care;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Personnel;Research Proposals;Research Training;Resource-limited setting;responsible research conduct;Risk;Role;service intervention;Sexually Transmitted Diseases;Site;skill acquisition;skills;standard care;standard of care;Statistical Methods;System;Technology;Telephone;Testing;Text Messaging;text messaging intervention;Time;tool;Training;Training Support;transmission process;treatment arm;Treatment Efficacy;two way texting;Viral;viral resistance;Visit;web based software;World Health Organization;Writing;young men who have sex with men

PROJECT_TITLE: A mobile phone short message service intervention to increase retention in HIV care among HIV-positive men who have sex with men in Peru (WelTel Peru)

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE This study evaluates the enduring protective impacts of a multi-level evidence-based intervention, ParentCorps, in high-poverty schools with pre-Kindergarten programs serving primarily Black and Latino children in New York City neighborhoods hit hard by the COVID-19 pandemic. Specifically, we examine the long-term impact of ParentCorps implemented in high-poverty schools with pre-Kindergarten programs on family-school connections, child mental health and school performance. We also engage with parents, educators and community stakeholders to understand school assets and needs not addressed directly by ParentCorps, and develop and integrate crisis mitigation strategies into the ParentCorps model.

PI_NAMEs: BROTMAN, LAURIE MILLER (contact);DAWSON-MCCLURE, SPRING

PROJECT_TERMS: academic standard;achievement test;Address;Adopted;adverse childhood events;Affect;Area;Black race;Caregivers;Cessation of life;Child;Child Care;Child Mental Health;Child Support;children of color;cohort;Color;Communities;community intervention;Country;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 risk;COVID-19 susceptibility;culturally appropriate intervention;design;Deterioration;Development;Disparity;early childhood;Economics;Education;educational atmosphere;effectiveness/implementation trial;Emotional;Ensure;Environment;Essential worker;Ethnic Origin;Evidence based intervention;experience;Experimental Designs;Exposure to;falls;Family;Family member;family support;Financial Hardship;food insecurity;Funding;Gender;Health;health disparity;high risk;Home;Home environment;Household;indexing;Intervention;Investments;Language;Latino;Learning;lower income families;maternal anxiety;maternal depression;member;Mental Depression;Mental Health;Methods;Modeling;Mothers;Natural experiment;neighborhood disadvantage;Neighborhoods;New York City;Nursery Schools;Outcome;pandemic disease;Parents;Performance;Personal Satisfaction;physical conditioning;Policy Maker;post-pandemic;Poverty;Predisposition;prevent;programs;protective factors;Race;Randomized;Recovery;Reporting;Research Infrastructure;Risk;Sampling;school closure;school district;Schools;Science;Security;social;social determinants;social stressor;Stress;Structural Racism;Students;Surveys;System;teacher;Testing;therapy design;United States National Institutes of Health;Vulnerable Populations;Well in self

PROJECT_TITLE: Multi-level evidence-based intervention to reduce health and education disparities among children of color in high-poverty schools in historically disinvested neighborhoods hardest hit by the pandemic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(58)R]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Infectious Diseases;Sexually Transmitted Infections;Urologic Diseases

ORG_CITY: CAPE TOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

PHR: Project Narrative This proposal will establish which HIV immune target cell populations found in the human foreskin can be infected with HIV-1. The objective is to identify molecular pathways and activation signals that determine this susceptibility and whether a male with an asymptomatic sexually transmitted infection has enhanced susceptibility. Repurposing interferon agonists will be assessed for activity as anti-virals in human foreskin and other cells.

PI_NAMEs: CHIGORIMBO-TSIKIWA, NYARADZO TSITSI (contact)

PROJECT_TERMS: African;Agonist;antagonist;Anti-viral Agents;Antibodies;Antigens;Biomedical Research;biomedical scientist;career;career development;CD4 Positive T Lymphocytes;Cell Lineage;Cell model;Cell Separation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chemokine;Chlamydia;Chlamydia trachomatis;Chronic;Collection;Communicable Diseases;cytokine;Data;desensitization;Development;drug discovery;dysbiosis;Engineering;Event;Flow Cytometry;Funding;Gene Expression Profile;Genes;Genitalia;Germany;Grant;healthy volunteer;Hepatitis B;Hepatitis C Therapy;HIV;HIV Infections;HIV vaccine;HIV-1;Human;human model;Immune;immune activation;Immune Targeting;Immunobiology;In Vitro;in vivo;Incidence;Individual;Infection;Inflammation;Inflammatory Response;inhibitor;insight;Interferons;International;Investigation;K-Series Research Career Programs;Knowledge;Label;Langerhans cell;Lead;Length;Lymphoid;Lymphoid Cell;Macrophage;male;Male Circumcision;Male Genital Organs;Mediating;Medical;men;Mentors;Mentorship;microbial;Modeling;Molecular;Mucous Membrane;Myelogenous;Myeloid Cells;Natural Immunity;novel;Oligonucleotides;Outcomes Research;Pathway interactions;Patients;penis foreskin;Peptide Hydrolases;Phenotype;Play;Population;Postdoctoral Fellow;Predisposition;Prevention strategy;Probability;programs;Protocols documentation;Publications;recruit;Reporter;reproductive tract;Research;Research Personnel;Research Project Grants;research study;response;Retroviridae;Risk;Role;sexual HIV transmission;Sexually Transmitted Diseases;Signal Transduction;South Africa;Suspensions;Techniques;Technology;Tissues;Training;transcriptomics;transmission process;Ubiquitin;United States National Institutes of Health;Universities;Viral;Viral Physiology;viral transmission;Virus;Virus Diseases

PROJECT_TITLE: Development of an HIV infection model of human foreskin to obtain novel insights into virus transmission


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PUBLIC HEATH RELEVANCE: Intervening with preschool-aged children to help them initiate a positive trajectory of interpersonal relationships and foster social and emotional development is of key importance for meeting key developmental tasks and to foster school readiness. However, little research to date has investigated intervention programs for reducing multiple forms of aggression and bullying behavior and promoting positive social and emotional skills among typically developing early childhood populations. This research will extend the existing program to a teacher-coaching model and will test three hypothesized but untested mechanisms that are targeted with the program as well as the moderating role of physiological reactivity and biological sex in a young sample; findings will provide important information to guide future large-scale prevention efforts.

PI_NAMEs: OSTROV, JAMIE M (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Accounting;Adaptive Behaviors;Address;Aggressive behavior;Area;Arousal;Autonomic nervous system;Behavior;behavior observation;Biological;Biological Factors;boys;bullying;bullying prevention;Caregivers;Child;Child Behavior;Child Development;Clinical;cohort;Competence;Control Groups;Data;Data Set;Development;early childhood;Early Intervention;early life adversity;economic disparity;Education;Effectiveness of Interventions;efficacy evaluation;efficacy testing;emotion regulation;Emotional;Environment;Environmental Risk Factor;Ethnic Origin;Evidence based program;executive function;experience;follow-up;Fostering;Friendships;Future;Galvanic Skin Response;Gender;girls;Goals;group intervention;high risk;Individual Adjustment;innovation;Interpersonal Relations;Intervention;intervention effect;intervention program;Interview;kindergarten;Learning;Literature;Mediating;Mediation;meetings;Methods;Modeling;National Institute of Child Health and Human Development;Nursery Schools;peer;peer victimization;Physiological;Physiological Processes;Physiology;policy implication;Population;Positioning Attribute;Preschool Child;Prevention;program dissemination;programs;Psychological adjustment;Psychopathology;psychosocial adjustment;public health relevance;Race;Randomized;Readiness;Reporting;Research;Research Priority;respiratory;Role;Sampling;scale up;School-Age Population;Schools;Sinus Arrhythmia;skill acquisition;skills;Skin;social;social disparities;social exclusion;social factors;social skills;teacher;Techniques;Testing;theories;therapy design;time use;treatment effect;Victimization;Work

PROJECT_TITLE: The Early Childhood Friendship Project: Testing Key Mechanisms and the Moderating Role of Physiological Reactivity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-J(02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Infectious Diseases;Pediatric;Social Determinants of Health

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: KENYATTA  NATIONAL  HOSPITAL

PHR: PROJECT NARRATIVE In 2017, an estimated 101,000 Kenyan adolescents aged 10-19 were living with HIV, the majority of whom are enrolled in school. Schools provide unparalleled access to adolescents, are critical for shaping long term health and life trajectories, and could be leveraged to support achievement of treatment goals. We propose a human centered design approach to gain an in-depth understanding of the school environment and its contribution to treatment goals, develop a school based intervention and pilot it for non-health outcomes (acceptability, feasibility and appropriateness), which aligns with the NIH K43 PAR non-clinical trials requirement.

PI_NAMEs: NJUGUNA, IRENE NYAMBURA (contact)

PROJECT_TERMS: Absenteeism;Achievement;Acquired Immunodeficiency Syndrome;Adherence;Adolescence;Adolescent;Adult;Africa;Africa South of the Sahara;Age;aged;antiretroviral therapy;Authorization documentation;Award;career;Caregivers;Caring;Cessation of life;Child;Chronic Disease;Clinic;Clinic Visits;Clinical;clinical epidemiology;Country;Decision Making;Development;Disclosure;Distant;Education;effective intervention;effectiveness testing;Enrollment;experience;Fright;Future;Goals;group intervention;Guidelines;Health;Health Personnel;Health Services Accessibility;HIV;HIV-infected adolescents;Hospitals;human centered design;implementation science;improved;improved outcome;Influentials;Infrastructure;Intervention;Interview;Kenya;Life;Link;Maps;Medicine;Mentors;Methods;multidisciplinary;Nurses;Outcome;peer;Peer Group;peer support;Performance;Pharmaceutical Preparations;pill;Policies;Policy Maker;Population;Positioning Attribute;preference;Primary Schools;Privacy;Procedures;Process;Productivity;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Training;Retrospective cohort study;Role;Sahara;Schedule;school environment;school health;School Health Services;School Nursing;School-Age Population;Schools;Scientist;Secondary Schools;Secondary to;Services;Shapes;skills;social stigma;Stigmatization;Structure;Surveys;teacher;Teacher Professional Development;Testing;therapy development;tool;Training;Training Support;Treatment outcome;United States National Institutes of Health;Viral;Work

PROJECT_TITLE: Understanding the role of schools in supporting HIV treatment outcomes among HIV infected adolescents


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative To prevent the spread of COVID-19, states have closed work sites, child care, and schools and introduced social distancing requirements. For many families, these policies have led to lost economic and other resources and an increase in parental emotional distress which together can contribute to a disruption in family routines, impacting children's diet, sleep, and physical activity and contributing to excess weight gain or obesity. This study will evaluate these concepts, in addition to examining the disproportionate effects of COVID-19 policies on children's health by race/ethnicity, family socio-economic status, and where they live (rural, urban, or suburban areas) and seeking to understand the economic impact of these policies on future health care costs as these children get older.

PI_NAMEs: HAGER, ERIN R (contact)

PROJECT_TERMS: Accelerometer;Age;Anniversary;Anxiety;Area;Cessation of life;Child;Child Care;Child Health;cohesion;comorbidity;County;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 prevention;COVID-19 treatment;Data;Data Collection;Diet;Disasters;Disparity;disparity reduction;Distress;economic impact;Economics;Emotional;emotional distress;Enrollment;Ethnic Origin;Evaluation;excessive weight gain;experience;Family;family support;follow-up;food insecurity;Fright;Funding;Future;future pandemic;Geography;Guidelines;Health;Health and Behavior in Children;Health behavior;Health Care Costs;health disparity;Health Services Accessibility;Hispanic;Home;improved;Income;Infection;Intervention;Interview;Investments;Life;Link;Locales;long term consequences of COVID-19;Longitudinal Studies;low socioeconomic status;Maryland;Measures;Mediating;Mental Depression;Methods;Modeling;Not Hispanic or Latino;Obesity;obesity in children;obesity prevention;obesity risk;obesity treatment;Outcome;pandemic disease;pandemic response;Pathway interactions;Pattern;Personal Satisfaction;Physical activity;Policies;Population;pre-pandemic;prevent;Prevention trial;protective factors;psychosocial;Public Facilities;Public Health;Race;Recovery;Research Project Grants;Resources;response;Risk;Rural;school closure;Schools;Services;Sleep;social;social disparities;Social Distance;Social support;Socioeconomic Status;Stimulus;Stress;stressor;suburb;Surveys;Time;Vulnerable Populations;Well in self;Workplace

PROJECT_TITLE: COVID-19 Policies: Impact Over Time on Child Health, Obesity, and Disparities


NIH_SPENDING_CATS: Aging;Back Pain;Pain Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Degenerative disc disease afflicts over 80 million Americans a year, and bears significant health care costs. We aim to define the pathways leading to intervertebral disc (IVD) degeneration. The research work proposed here examines the role of Advanced Glycation End-products (AGEs) in the context of aging and diabetes, and the signaling of its receptor (RAGE) as a novel disease mechanism for the degeneration and inflammation of the IVD.

PI_NAMEs: TANG, SIMON YUE-CHEONG (contact)

PROJECT_TERMS: Ablation;Acceleration;activation product;adduct;Advanced Glycosylation End Products;age effect;Aging;American;Amino Acids;Attenuated;Back Pain;Biochemical;Biological;Biology;Catabolism;Cells;Chronic;chronic back pain;comorbidity;Complex;contrast enhanced;cost;crosslink;cytokine;Data;Deterioration;Diabetes Mellitus;Disease;effective therapy;Epidemic;Event;extracellular;Extracellular Matrix;Functional disorder;Funding;glycation;Health Care Costs;Image;Immune response;Impairment;In Vitro;in vivo;in vivo evaluation;Inflammation;Inflammatory;Inflammatory Response;Injury;Intervertebral disc structure;intervertebral disk degeneration;Knowledge;Mechanics;Mediating;microCT;Modification;NF-kappa B;Non-Insulin-Dependent Diabetes Mellitus;novel;nucleus pulposus;Organ Culture Techniques;Pathologic;Pathology;Pathway interactions;Performance;Physiological;Predisposition;preservation;Prevalence;Process;Proteins;Proteoglycan;Public Health;receptor;receptor for advanced glycation endproducts;Research;Resolution;Risk Factors;Role;Signal Transduction;spinal disk injury;Structure;sugar;technological innovation;Tissues;transmission process;Work

PROJECT_TITLE: The role of physiologic and pathologic AGEs on RAGE signaling in IVD degeneration

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Cholera surveillance and control strategies rely primarily on detecting symptomatic cases that seek care; mild infections and infections in individuals with barriers in access to healthcare are often unobserved. This project aims to examine the degree to which unobserved infections contribute to the burden and transmission of Vibrio cholerae. The approaches used in this study are relevant to a broad range of infectious diseases and will lay the groundwork for addressing critical questions about the host, microbial, and socio-demographic factors that contribute to infections going unobserved, ultimately leading to more effective mitigation strategies.

PI_NAMEs: WIENS, KIRSTEN E (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: 2019-nCoV;Address;Age;Antibiotics;Area;Bacteria;Bangladesh;care seeking;Caring;Cessation of life;Cholera;Clinical;clinical diagnosis;Communicable Diseases;Data;Democratic Republic of the Congo;design;Diagnosis;Diarrhea;Ebola;efficacy study;Epidemic;Exposure to;Feces;Goals;health care availability;Hospitals;Household;human pathogen;Immunity;Individual;Infection;infection risk;insight;Knowledge;Laboratories;Location;Malaria;Medical;Methods;microbial;outbreak control;pathogen;Pattern;Persons;Play;Population;Predisposition;prevent;Prevention;Probability;Resources;Risk;Risk Estimate;Risk Factors;Role;secondary infection;Serology;serosurvey;sociodemographic factors;Source;stool sample;Symptoms;Testing;transmission process;vaccine efficacy;Variant;Vibrio cholerae;Vibrio cholerae infection;Work

PROJECT_TITLE: The role of unobserved cholera: implications for prevention and control

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Pasadena

ORG_NAME: ACURASTEM, INC.

ORG_STATE: CA

PHR: Development of a SYF2 antisense oligonucleotide treatment for ALS and FTD Project Narrative Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are complex diseases that result from many diverse causes. While there are currently no drugs that slow the progression of ALS or FTD, most of the new promising therapeutic strategies are focused narrowly on modifying the specific genetic mutations known to cause disease, however these treatments won’t work for the vast majority (>80% in ALS) of patients for whom the genetic cause of their disease is not known. Therefore, AcuraStem’s focus has been to develop treatments that can work for all ALS and FTD patients, including those for whom the genetic factors driving their disease have yet to be discovered - a large population with urgent unmet need.

PI_NAMEs: ALWORTH, SAMUEL V (contact);FENG, ZHIHUA

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Address;Adult;Affect;Alleles;ALS patients;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Artificial Human Chromosomes;Automobile Driving;Autopsy;Bacterial Artificial Chromosomes;Bioinformatics;Biological Markers;Brain;C9ORF72;causal variant;Cell Nucleus;Central Nervous System;Chemicals;Childhood;cohort;commercialization;Complex;Cytoplasm;Data Set;design;Development;Disease;DNA Sequence Alteration;Dose;Evaluation;Exons;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Generations;Genes;Genetic;genetic approach;Genetic Predisposition to Disease;glial activation;Government;Human;immunogenicity;improved;in silico;Inclusion Bodies;Individual;Investigational Drugs;Investments;lead candidate;loss of function;manufacturability;Maximum Tolerated Dose;motor disorder;mouse model;Mus;Nerve Degeneration;Neuromuscular Junction;Neurons;new therapeutic target;novel therapeutic intervention;Outcome;Pathologic;Pathology;Patients;Peripheral;Persons;Pharmaceutical Preparations;Phase;Phenotype;Population;Pre-Clinical Model;Probability;protein TDP-43;RNA;RNA Splicing;Rodent;screening;Software Design;Spinal Cord;Spliceosomes;sporadic amyotrophic lateral sclerosis;stathmin;success;TDP-43 aggregation;Therapeutic;Therapeutic Index;Tissues;Toxic effect;Transgenic Mice;Work


ADMINISTERING_IC: GM

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Wound Healing and Care

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Tissue repair is essential for organisms to survive and involves a coordinated set of cellular behaviors. My laboratory is interested in the basic cellular and genetic mechanisms that control diverse tissue repair responses like epithelial wound closure, spreading of inflammatory cells, and nociceptive sensitization. We employ the fruit fly Drosophila in our studies and our goal is to understand the basic mechanistic conserved biology that underlies a successful multi-tissue healing response to tissue damage.

PI_NAMEs: GALKO, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Actins;Acute;Adherens Junction;Adhesions;Animal Behavior;base;beta catenin;Biology;Blood Cells;Cell Adhesion;cell behavior;Cell Physiology;Cells;Cellular biology;Chemicals;complement system;coping;Creativeness;Drosophila genus;embryo tissue;Environment;epithelial wound;Epithelium;Evolution;Excision;Funding;gene function;Genes;Genetic;Germ Cells;Goals;Grant;healing;Image;Immune;Inflammation;Inflammatory;Injury;insight;interest;Laboratories;Larva;mechanical stimulus;Mediating;Membrane;Molecular;Nociception;novel;Organism;Pain;polymerization;Polymers;Positioning Attribute;Postembryonic;Process;Proteins;Recording of previous events;repaired;Research;response;Sensory;Signal Pathway;Signal Transduction;Site;Time;tissue repair;tissue-repair responses;Tissues;tool;Vascular Endothelial Growth Factors;Work;wound;wound closure;wound healing;Writing

PROJECT_TITLE: The molecular and genetic bases of diverse tissue repair responses in postembryonic Drosophila

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: EL PASO

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: NARRATIVE Chagas disease, caused by the parasite Trypanosoma cruzi, affects millions of people in Latin America and is an emerging disease in the U.S. and other nonendemic countries. Currently, the only approved drugs for treating Chagas disease are benznidazole and nifurtimox, which are toxic and have low efficacy in the treatment of chronic infection. In this clinical trial study, we propose to test new regimens of these drugs to improve their safety and efficacy, and develop novel diagnostic tools that will provide a more efficient measure of disease state and treatment outcomes.

PI_NAMEs: ALMEIDA, IGOR C (contact);GASCON, JOAQUIM ;TORRICO, FAUSTINO

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acute;Adult;Adverse drug event;Adverse event;Affect;Aftercare;Age;Animals;Antibodies;Antigens;Antioxidants;Antiparasitic Agents;Appearance;aptamer;Benznidazole;Biological Markers;Blood;Cardiomyopathies;Chagas Disease;chemotherapy;Chemotherapy-Oncologic Procedure;Child;Chronic;chronic infection;Chronic Phase;Classification;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Country;Data;detection method;diagnostic tool;Disease;Dose;Drug Combinations;drug efficacy;Drug Kinetics;early detection biomarkers;Evaluation;Excretory function;experience;Failure;follow-up;Frequencies;Heart;Heat-Shock Proteins 70;improved;Infant;Infection;Inflammatory;Latin America;Lytic;Measures;Nifurtimox;novel;novel diagnostics;Oxidative Stress;Parasitemia;Parasites;Parasitology;Patients;Peptide antibodies;Peptides;Peripheral;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Play;Polysaccharides;Population;prognosis biomarker;progression marker;Proteins;Public Health;Reaction;Recombinant Proteins;Regimen;Reporting;Research Design;response;Role;Safety;seroconversion;Serology;Serum;standard care;success;Symptoms;Testing;Therapeutic;therapy outcome;Thrombophilia;tool;treatment duration;Treatment outcome;Treatment Protocols;treatment response;Trypanosoma cruzi

PROJECT_TITLE: New chemotherapy regimens and biomarkers for Chagas disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Microbiome;Organ Transplantation;Transplantation

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Tacrolimus is utilized to prevent rejection of the kidney transplant but has a narrow therapeutic window with subtherapeutic tacrolimus levels associated with acute rejection and supratherapeutic levels associated with nephrotoxicity and neurotoxicity. The overall objective of this study is to define the relationship between the gut microbiota and tacrolimus trough variability in kidney transplant recipients. Our study will enable development of gut-based and blood-based biomarkers to identify kidney transplant recipients at high risk for tacrolimus trough variability.

PI_NAMEs: JEONG, HYUNYOUNG ;LEE, JOHN RICHARD (contact)

PROGRAM_OFFICER_NAME: ROBIEN, MARK ANDREW

PROJECT_TERMS: Acute;bacterial metabolism;Biological Markers;Blood;blood-based biomarker;Clinical;Clinical Research;Collection;Development;donor-specific antibody;End stage renal failure;gut microbes;gut microbiome;gut microbiota;high risk;Immunologics;Immunosuppressive Agents;improved;In Vitro;in vivo;Individual;Kidney Transplantation;Life;Measurement;Metabolism;metagenomic sequencing;Monitor;nephrotoxicity;neurotoxicity;novel strategies;Oral Administration;Organism;Outcome;Parents;patient variability;Patients;personalized approach;Pharmaceutical Preparations;Pilot Projects;Population;Predictive Factor;predictive marker;prevent;Procedures;Production;recruit;Research Design;Risk;secondary analysis;Specimen;Study Section;Tacrolimus;Therapeutic;Therapeutic immunosuppression;Transplant Recipients;Transplantation;Work

PROJECT_TITLE: Gut Microbiota and Tacrolimus Trough Variability in Kidney Transplant Recipients

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ORG_CITY: HERSHEY

ORG_DEPT: SURGERY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative The objective of this project is to develop a Total Artificial Heart (TAH) to provide a durable destination therapy as an alternative to heart transplantation. The approach uses two independent rotary blood pumps with integrated inflow pressure sensors. This approach provides flexibility in anatomic positioning in small patients, and the ability to control left atrial pressure and total pump output according to physiologic demand.

PI_NAMEs: CYSYK, JOSHUA P (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Acute;Anatomy;Angiodysplasia;Animal Testing;Animals;biomaterial compatibility;blood pump;Blood Tests;Cannulations;Cardiac Output;Cattle;Central venous pressure;Chronic;Complex;cost;design;Destinations;Development;Device Designs;Devices;Electronics;Equilibrium;Exercise;experience;flexibility;Funding;Future;Generations;Heart;Heart Atrium;Heart failure;Heart Transplantation;Hemolysis;Hemorrhage;Hemostatic function;human disease;Implant;Incidence;Inferior;Intestines;Journals;Left;Left atrial structure;left ventricular assist device;Licensing;Liquid substance;Measures;Methods;Modeling;Molecular Weight;mortality;Motor;operation;Operative Surgical Procedures;Output;Patients;Peripheral Resistance;Physiological;Positioning Attribute;preservation;pressure;pressure sensor;Pulmonary Vascular Resistance;Pulsatile Flow;Pulse Pressure;Pump;Quality of life;response;Right atrial structure;right ventricular failure;Risk;Speed;Sturnus vulgaris;System;Testing;Thromboembolism;Thrombosis;Thrombus;Time;total artificial heart;transmission process;treadmill;Tube;Universities;Vascular resistance;Venous;Ventricular;von Willebrand Factor;wireless

PROJECT_TITLE: Development of a Universal Bi-ventricular Replacement System for the Failing Heart

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Radiation Oncology;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE: Uncertainties in the current offline feedforward processes of radiotherapy delivery are limiting its tumor curative effectiveness, or increasing the exposure of uninvolved normal tissue resulting in short- and long-terms side effects, or both, therefore, this proposal will investigate an online feedback, ultrasound-based system to better guide the delivery of the radiation beam onto the tumor at the time of treatment. This system integrates X-ray acoustics and ultrasound imaging, which uniquely enables simultaneous imaging of the deposited dose and the targeted tumor anatomy during radiation delivery. The system will be evaluated for measurement accuracy and motion compensation using phantoms and animals; and for clinical use for tumors in the liver and pancreas.

PI_NAMEs: EL NAQA, ISSAM M. (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;3D ultrasound;Abdomen;absorption;acoustic imaging;Acoustics;Affect;anatomic imaging;Anatomy;Animals;Area;Calibration;Cancer Patient;cancer site;cancer type;Caring;Cesarean section;Characteristics;Clinic;Clinical;Clinical Research;Clinical Treatment;Compensation;cost;cost effective;Deposition;Detection;detector;Diagnostic Imaging;Dose;dosimetry;effective therapy;Effectiveness;Elements;Exposure to;Feedback;Gel;Generations;Geometry;Goals;Image;image guided;improved;in vivo;Investigation;Ionizing radiation;Lasers;Linear Accelerator Radiotherapy Systems;Liver;Location;Magnetic Resonance Imaging;Malignant neoplasm of abdomen;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Measures;Medical Imaging;Methods;Modeling;Monitor;Morphologic artifacts;Motion;Normal tissue morphology;novel;Oncology;Online Systems;Optics;optimal treatments;Organ;Oryctolagus cuniculus;Outcome;Pancreas;Patients;Pattern;Penetration;Performance;phantom model;photoacoustic imaging;Physiological;Pilot Projects;Pre-Clinical Model;Process;Property;Radiation;radiation delivery;Radiation Dose Unit;Radiation Oncology;Radiation Physics;Radiation therapy;real-time images;Reporting;Resolution;respiratory;response;Roentgen Rays;Rotation;Safety;Shapes;side effect;Signal Transduction;System;Systems Integration;systems research;Technology;Testing;Three-Dimensional Imaging;Time;Tissues;tomography;Toxic effect;Transducers;translational potential;Treatment outcome;treatment planning;tumor;tumor eradication;Ultrasonography;ultrasound;Uncertainty;Variant

PROJECT_TITLE: Combined radiation acoustics and ultrasound imaging for real-time guidance in radiotherapy


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The primary objective of our proposal is to develop a separation technology to enrich a population of lymphocytes with tumoricidal T-cells based on their capacity to recognize autologous tumor antigens. Accomplishing our primary goal will create a disruptive cell separation technology that would significantly lower the barriers for broad dissemination of T-cell based immunotherapies for cancers.

PI_NAMEs: SHIRURE, VENKTESH  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Acceleration;Adoptive Cell Transfers;Affinity;anti-cancer research;antigen-specific T cells;Autologous;Autologous Tumor Cell;Biomedical Engineering;Blood;Blood Cells;cancer cell;cancer immunotherapy;Cancer Patient;CD8-Positive T-Lymphocytes;Cell Adhesion;Cell Density;Cell Fraction;Cell Line;Cell Separation;Cells;Cellular immunotherapy;Clinical;Clinical Oncology;Collaborations;cost;Device Designs;Devices;Dimensions;Exposure to;Goals;Heterogeneity;Immunology;improved outcome;interest;Interferon Type II;Knowledge;Leukocytes;Lymphocyte;Major Histocompatibility Complex;Malignant Neoplasms;MART-1 Tumor Antigen;Melanoma;Melanoma patient;Methods;Microfluidic Microchips;microfluidic technology;Microfluidics;Molecular;neoplastic cell;new technology;novel therapeutic intervention;Patients;Peptides;Perfusion;peripheral blood;Peripheral Blood Lymphocyte;Peripheral Blood Mononuclear Cell;personalized medicine;Population;Preparation;Process;programs;Publishing;Research Personnel;Sampling;Source;statistics;success;Surface;Surgical Oncology;T cell receptor repertoire sequencing;T cell therapy;T-Lymphocyte;Technology;technology development;tumor;Tumor Antigens;Tumor-Derived;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Microfluidic technology to isolate tumoricidal T-cells from peripheral blood


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Precision Medicine;Serious Mental Illness

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Approximately 25 million people suffer from posttraumatic stress disorders (PTSD) in the United States at any given point in time; with 30-50% of PTSD patients not responding to first line therapies, novel treatments are needed. The goal of this K01 proposal is to provide critical training in focal neuromodulation, clinical investigations and functional connectivity analyses, and to test the scientific premise that 1Hz DLPFC Transcranial Magnetic Stimulation (TMS) improves PTSD neuroimaging and psychophysiological biomarkers. Investigating the effect of TMS on measurable neuroimaging and psychophysiological targets within the fear neurocircuitry is the next step for defining novel targets for brain stimulation in PTSD and identifying phenotypes that best predict response to TMS for a personalized treatment approach.

PI_NAMEs: VAN ROOIJ, SANNE JH (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acceleration;African American;Aftercare;Amygdaloid structure;Biological;Biological Markers;Brain;career;career development;Clinical;clinical investigation;Cognitive;comorbidity;conditioned fear;Cues;Data;Data Analyses;Development;Disease;Distal;Dose;Down-Regulation;Dropout;Emotional;experience;experimental study;FDA approved;Financial Hardship;Foundations;Fright;Functional impairment;Funding;Future;Galvanic Skin Response;Goals;healthy volunteer;high risk;Hippocampus;Hospitals;Impairment;improved;Individual Differences;Infrastructure;interest;Intervention;Low income;Major Depressive Disorder;Measurable;Measures;Mental disorders;Mentors;MRI Scans;neural circuit;neurobiological mechanism;Neurobiology;neuroimaging;neuroimaging marker;neuromechanism;Neuronavigation;neuroregulation;Neurosciences;novel;Outcome;Outcome Measure;Patient Recruitments;Patients;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Phenotype;Physiologic pulse;Physiology;Placebos;Population;Post-Traumatic Stress Disorders;predicting response;predictive marker;Prefrontal Cortex;Primary Care;primary care clinic;programs;Protocols documentation;Psychiatric therapeutic procedure;Psychophysiology;Randomized;Recovery;recruit;Regulation;Research;Research Personnel;research study;response;Safety;Site;Startle Reaction;Stimulus;Structure;study population;suicidal risk;Symptoms;Testing;Therapeutic Effect;Time;Training;Transcranial magnetic stimulation;Trauma;trauma exposure;treatment duration;Treatment Efficacy;Treatment outcome;treatment response;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Effect of TMS on PTSD Neuroimaging and Psychophysiological Biomarkers

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SANTA BARBARA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project Narrative This Program trains predoctoral researchers in mechanobiology: the relationship between molecular events and mechanical forces in living systems. Training in both the quantitative and biological sciences will foster creative thinking across disciplinary lines, leading to the development of innovative materials, methods and measurement tools to advance human health. Trainees from diverse disciplines, backgrounds, and groups will be prepared to lead rigorous biomedical research programs and promote scientific advances in academia, industry, national labs, and technology and policy careers.

PI_NAMEs: PRUITT, BETH L (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: pre-doctoral;Training Programs

PROJECT_TITLE: Predoctoral Training Program in Quantitative Mechanobiology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]