ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Rehabilitation;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The proposed trial will provide one of the first rigorous tests of whether the effects of topiramate in AUD generalize to patients with co-occurring PTSD, and one of the first rigorous tests of whether topiramate has beneficial effects on PTSD symptoms in this population. It will be the first study to test whether the rs2832407 genotype predicts clinical response to topiramate for AUD and PTSD in patients with both disorders. Further, it will contribute to the understanding of topiramate’s mechanisms of action in the co- morbid AUD/PTSD population, and to the discovery of predictors of treatment response.

PI_NAMEs: MARMAR, CHARLES R. (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Address;Affect;alcohol abuse therapy;alcohol comorbidity;Alcohol consumption;alcohol use disorder;Alleles;Animal Model;Anticonvulsants;anxiety reduction;anxiety-like behavior;biological adaptation to stress;Biological Markers;Brain Chemistry;Clinical;clinical predictors;Code;comorbidity;Complex;Data;Disease;Double-Blind Method;Effectiveness;Ensure;executive function;FDA approved;Funding;Genes;Genetic Polymorphism;Genotype;glutamatergic signaling;Goals;Homozygote;incentive salience;Individual;insight;Institution;Kainic Acid Receptors;negative affect;Neurobiology;neuroimaging marker;open label;Patients;personalized biomarkers;Placebos;Plasma;Population;Post-Traumatic Stress Disorders;preclinical study;Prediction of Response to Therapy;randomized, clinical trials;recruit;response;Secure;Stress;Symptoms;Testing;Therapeutic;Time;topiramate;Treatment Efficacy

PROJECT_TITLE: Leveraging biomarkers for personalized treatment of alcohol use disorder comorbid with PTSD


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE Tuberculosis (TB) remains a leading cause of death from infectious diseases globally. Understanding why some infected individuals develop disease and others do not is paramount to developing preventative treatments. We discovered an unexpected association between TB susceptibility and inhibition of tyrosine metabolism, which could be leveraged as a novel target for preventative therapy against TB progression.

PI_NAMEs: SULIMAN, SARA  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acetoacetates;Acute;acute infection;Adoptive Transfer;African;Amino Acids;Aromatic Amino Acids;biobank;Biological Assay;Catabolism;Cause of Death;Cells;Citric Acid Cycle;cohort;Collaborations;Communicable Diseases;Complement;CRISPR/Cas technology;Data;Data Set;Defect;Dendritic Cells;Development;Disease;Disease Progression;Down-Regulation;Enrollment;Enzymes;Exhibits;experimental study;extracellular;Fetal Liver;Fumarates;Fumarylacetoacetase;Future;Generations;Genes;Genetic Polymorphism;genetic variant;Genotype;Genus Hippocampus;Glycolysis;Growth;Hematopoietic;Hematopoietic stem cells;Hepatocyte;Hereditary Disease;high risk;Household;Human;Hydrolysis;Immune Evasion;Immune response;immunoregulation;Impairment;In Vitro;in vivo;Individual;Infection;Inflammatory;Intervention;Isotope Labeling;Knock-out;Longitudinal cohort;Macrophage;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;monocyte;mortality;Mus;Mycobacterium tuberculosis;Myeloid Cells;Myeloid Progenitor Cells;Nitric Oxide;Nitrogen;novel;Nutrient;Oxidative Phosphorylation;pathogen;Pathogenesis;Pathway interactions;Patients;permissiveness;Persons;Peruvian;Phagocytes;Phase;Phenylalanine;Phenylalanine Metabolism Pathway;Plasma;Predisposition;Preventive therapy;Preventive treatment;Production;prophylactic;prospective;Publishing;Recording of previous events;Resolution;response;Risk;Role;Sampling;Series;Serum;Supplementation;Testing;transcriptome sequencing;Transgenic Organisms;Tuberculosis;Tyrosine;Tyrosine Metabolism Pathway;uptake;Variant;Virulence

PROJECT_TITLE: The role of tyrosine metabolism in tuberculosis pathogenesis

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Neurosciences;Regenerative Medicine

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PI_NAMEs: WALKER, LAUREN J (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: analysis pipeline;Anatomy;Axon;axon growth;axon guidance;axon regeneration;Back;Biology;candidate identification;career;cell type;Cells;Centers of Research Excellence;Chromium;Collaborations;Complex;Cues;Data;Data Science Core;Data Set;Dedications;Development;differential expression;Disease;Forelimb;Foundations;Funding;Future;Generations;Genome;Goals;Growth;in vivo;Individual;Injury;injury recovery;insight;Knowledge;Label;Lasers;Location;Mediating;Mentorship;Modeling;Molecular;Molecular Profiling;Monitor;Motor;motor axon regeneration;Motor Neurons;Movement;Muscle;Natural regeneration;nerve supply;Nervous System;neural circuit;Neuroglia;neuronal guidance;Neurons;Organism;Pectoral;perineural;Population;programs;receptor;Recovery;regenerative;repaired;Research;Resolution;RNA;Role;Route;Schwann Cells;Signal Transduction;single cell genomics;single cell sequencing;single-cell RNA sequencing;Sorting;Spatial Distribution;Specific qualifier value;Synapses;Target Populations;Testing;Tetrapoda;tissue regeneration;tool;Transcript;transcriptome;transcriptomics;Transgenic Organisms;United States National Institutes of Health;Visualization;Work;Zebrafish

PROJECT_TITLE: Neuronal guidance landscape across development and regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (C2)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Mental and oral health co-morbidities associated with HIV and lifelong treatment could be driven by biological processes, including microbiota- or aging-mediated mechanisms. A better understanding of how these mechanisms contribute to neurocognitive impairments and oral conditions is needed to support interventions, particularly in adolescence. This proposal focuses on identifying oral microbial taxonomic and functional features, and epigenetic aging markers associated with neurocognition and oral health in adolescents with HIV.

PI_NAMEs: COKER, MODUPE  (contact);SHIAU, STEPHANIE

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TITLE: Uncovering the Biological Link between Oral and Mental health in Adolescents Living with HIV (uBLOoM)


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative Programmable nucleic acid targeting tools such as CRISPR provide a new modality for programmable RNA targeting but current RNA-targeting tools suffer from potential issues with safety, specificity, and versatility. We propose to develop new, specific RNA-targeting CRISPR systems without off-target collateral activity in cells and engineer these systems to generate new RNA writing technologies capable of all possible base conversions, insertions or deletions of any size, and exon replacement. The technologies developed from this work will accelerate the study and modeling of disease biology and provide a revolutionary platform for RNA-based therapeutics, including many triplet repeat disorders.

PI_NAMEs: ABUDAYYEH, OMAR O;GOOTENBERG, JONATHAN SAMUEL (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Acceleration;base;base editing;Binding;Biochemical;Bioinformatics;Biology;Biomedical Research;causal variant;Cell model;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Development;Disease;disease model;DNA;DNA Viruses;Dose;Engineering;Enzymes;Excision;Exons;Family;gene editing technology;Genes;Genetic Diseases;Genome;genome editing;Guide RNA;improved;Individual;Induced pluripotent stem cell derived human neuron;insight;knock-down;Location;Methods;Modality;Modification;Molecular Biology;mRNA Precursor;Neurodegenerative Disorders;Neurologic;neuropsychiatric disorder;novel;novel therapeutics;nuclease;Nucleic Acids;Orthologous Gene;Patients;Performance;Point Mutation;Process;Protein Engineering;Proteins;Reaction;recruit;Research Personnel;Resources;RNA;RNA Editing;RNA Sequences;RNA Splicing;Safety;Specificity;structural biology;success;System;Technology;technology development;Therapeutic;therapeutic RNA;therapeutically effective;Tissues;tool;Toxic effect;Trans-Splicing;Transcript;Translations;Trinucleotide Repeats;Work;Writing

PROJECT_TITLE: Developing programmable RNA writing tools with the novel RNA-guided RNA-targeting CRISPR effector Cas7-11

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: COOPER, LISA A (contact);CREWS, DEIDRA CANDICE

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TITLE: The Mid-Atlantic Center for Cardiometabolic Health Equity (MACCHE) Diversity Supplement


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Rare Diseases;Rheumatoid Arthritis

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Aggregating across biological datasets reveals a patchwork of different technologies and conditions of interest; however, several holes exist in this patchwork, hindering our ability to entirely utilize biological datasets that currently exist. We propose to use a special class of methods, called domain adaptation methods, that can leverage the local patterns in the patchwork to build models that can either work around the missing pieces or fill them in. To show the strength and flexibility of these approaches, we apply our methods to three biomedical application areas: 1) inferring missing cell-type-specific treatment responses in Rheumatoid Arthritis; 2) predicting the tissue-of-origin of cell-free DNA (cfDNA) from a model trained on a different but complementary data type to cfDNA; 3) predicting gene expression patterns in the bone marrow from cfDNA.

PI_NAMEs: DAVIDSON, NATALIE ROSE (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Adopted;Aftercare;Area;Atlases;Autoimmune Diseases;Beneficence;Biodiversity;Biological;Biological Markers;Biological Sciences;biological systems;Biology;Biopsy;Bone Marrow;Bone marrow biopsy;Bone Marrow Cells;Bypass;Cancer Detection;career;cell free DNA;Cell model;cell type;Cells;Cellular Assay;Chromatin;Clinical Sciences;cohort;Colorado;Computational Biology;Computational Technique;Data;Data Reporting;Data Set;Dimensions;Disease;Disease-Modifying Second-Line Drugs;Dissociation;diverse data;DNA;Emerging Technologies;Epigenetic Process;Etiology;Evaluation;experience;Face;flexibility;Foundations;Frequencies;Gene Expression Profile;generative models;genetic signature;Goals;Graft Rejection;Health;High-Throughput Nucleotide Sequencing;Incidence;Information Technology;insight;Institution;Interdisciplinary Study;interest;Learning;learning strategy;Machine Learning;Malignant Neoplasms;Masks;Measurement;Medical;Mentors;Methodology;Methods;minimally invasive;Modality;model building;Modeling;Molecular;Monitor;multiple omics;new technology;novel sequencing technology;Outcome;Patients;Pattern;Phase;Procedures;Process;progenitor;programs;Proteomics;Research;Research Personnel;Resolution;Resources;response;Rheumatoid Arthritis;RNA;Sampling;Scientist;Severities;Severity of illness;single cell sequencing;Solid;Source;stem cells;T-Lymphocyte;Techniques;Technology;Tissues;tool;Training;transcriptome sequencing;transcriptomics;Translational Research;translational research program;Transposase;treatment effect;treatment response;Universities;Work

PROJECT_TITLE: Domain adaptation approaches to unify established and emerging sequencing technologies

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: To increase the number of clinical trials in IDeA states, sites need to be able to accurately report key metrics of clinical trial infrastructure. This supplemental application seeks support for ISCORE-RC charter member sites to improve their infrastructure by either implementing a clinical trials management system or generating reports containing key clinical trial metrics from existing clinical trials management systems. This project is critically important to achieving the overarching goal of increasing clinical trial offerings in IDeA states.

PI_NAMEs: HODDER, SALLY LYNN (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Address;Award;Clinical Research;Clinical Trials;Collection;Communication;Contracts;Development;Drug Industry;Goals;Human Resources;improved;Infrastructure;Institution;Institutional Review Boards;Marketing;Mediation;member;participant retention;Population;programs;recruit;Reporting;Resources;Services;Site;System;Time;Training;United States National Institutes of Health;Workforce Development

PROJECT_TITLE: The IDeA State Consortium for a Clinical Research Resource Center: Increasing Clinical Trials in IDeA States through Communication of Opportunities, Effective Marketing, and Workforce Development


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Pediatric;Pediatric - AIDS;Pediatric Cancer;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Perinatal exposure to HIV can affect both the oral immune system and the microbes that normally inhabit the mouth (including the bacterial microbiome), which may increase the risk of oral HPV infection. Using a large cohort of children born to HIV-infected mothers (and, for comparison, children born to uninfected mothers) from Nigeria, this study seeks to understand the risk of oral HPV infection and role of the oral microbiome in youth perinatally exposed or/and infected with HIV.

PI_NAMEs: COKER, MODUPE  (contact);OSAZUWA-PETERS, NOSAYABA

PROJECT_TERMS: Adolescence;Adolescent;Adult;advanced analytics;Affect;Africa South of the Sahara;Age;aged;antiretroviral therapy;Anus;Bacteria;bacterial community;bacteriome;cancer epidemiology;Cancer Patient;cancer prevention;CD4 Positive T Lymphocytes;Cell Count;Cervical;Child;Childhood;Clinical;clinical practice;cohort;cytokine;Data;deep learning algorithm;deep learning model;Detection;Development;Disease;Eligibility Determination;Epidemiology;Exhibits;Exposure to;follow-up;Foundations;Frequencies;Funding;Future;Hemophilus;high risk;HIV;HIV Infections;HIV Seronegativity;HPV negative;HPV oropharyngeal cancer;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune response;Immune system;Immunologic Markers;Immunologics;Impairment;Incidence;Individual;Infection;Inflammatory;inflammatory marker;innovation;Interleukin-10;Interleukin-6;Intervention;intervention program;Investigation;Knowledge;Lactobacillus;Leptotrichia;Low Prevalence;malignant mouth neoplasm;Malignant Neoplasms;malignant oropharynx neoplasm;Measures;Mediating;metagenomic sequencing;Microbe;microbial;microbial community;microbiome;microbiota;Molecular;Mothers;Mouth Diseases;National Institute of Dental and Craniofacial Research;Natural History;Neisseria;neural network;Nigeria;Nigerian;Observational Study;Oral;Oral cavity;Oral Characters;Oral health;oral HPV;oral HPV infection;oral lesion;oral microbial community;oral microbiome;Oral mucous membrane structure;Pathology;Pathway interactions;Patients;Pattern;Perinatal Exposure;perinatal HIV;Persons;Population;predictive modeling;Predisposition;prevent;Prevention;Prevention strategy;preventive intervention;Prevotella;prospective;Prospective Studies;Reaction;recruit;Regimen;Reporting;Risk;Risk Factors;risk mitigation;Role;saliva sample;Salivary;Sampling;sex;sexually active;Shotgun Sequencing;Shotguns;Taxonomy;Technology;Testing;Therapeutic Intervention;Time;Training;Translating;treatment strategy;Tumor Promotion;United States National Institutes of Health;Vaccination;Vaccines;Viral Load result;whole genome;Woman;Youth

PROJECT_TITLE: HPV, HIV and Oral Microbiota Interplay in Nigerian Youth (HOMINY)


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Prevention

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE The close out funds will support completion of DiAL Health (U01 AG073204), a planning project to pilot test and optimize dietary approaches to slow aging and design a long-term trial. DiAL Health is a multi-site study, with sites at Pennington Biomedical in Baton Rouge, Louisiana and the University of Alabama Birmingham. The close out funds will be used to finish the study, including completion of participant follow-up appointments, ensuring their safety and completion of data collection on the remaining participants.

PI_NAMEs: MARTIN, CORBY K (contact);REDMAN, LEANNE MAREE

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Adherence;Administrative Supplement;Affect;Aging;aging biomarker;Alabama;Applications Grants;Appointment;biological age;Biological Aging;Biological Markers;Biomedical Research;Body Weight decreased;Caloric Restriction;Cell Aging;Consultations;cost;Data;Data Collection;deregulated nutrient-sensing;design;Desire for food;Diet;dietary approach;Dietary Intervention;disorder risk;DNA Methylation;Doctor of Philosophy;Eating;eligible participant;Enrollment;Ensure;Epigenetic age;Epigenetic Process;extend lifespan;Feedback;Focus Groups;follow-up;Food;Funding;Future;Genomic Instability;Grant;hallmarks of aging;Health;Health Technology;healthspan;Hour;Human;improved;indexing;Individual;intercellular communication;Intervention;intervention effect;intervention refinement;Intervention Trial;Learning;Louisiana;Manuals;Marketing;Measures;Methods;mHealth;middle age;mitochondrial dysfunction;Monitor;novel;Nutritional;Outcome;parent project;Participant;Patient Outcomes Assessments;Persons;pilot test;Procedures;proteostasis loss;Protocols documentation;Quality of life;Risk Factors;Rodent;Safety;Sample Size;satisfaction;Site;stem cell exhaustion;Telomere Shortening;Testing;Time;Time-restricted feeding;Universities;Visit;Writing

PROJECT_TITLE: Administrative Supplement: A planning project to pilot test and optimize dietary approaches to slow aging and design a long-term trial


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Alabama has launched a statewide action plan for cervical cancer elimination as a public health problem known as OPERATION WIPE OUT. We propose to expand and examine the feasibility of an integrated theory-driven, participatory multi-channel communication campaign to promote HPV vaccination, cervical cancer screening, and follow-up with high school students being agents of change with the support of OPERATION WIPE OUT partners and linked to school- based vaccination as well access to HPV vaccination, screening, and follow-up in the community.

PI_NAMEs: SLECKMAN, BARRY P (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Academia;Address;Adherence;Administrator;Adoption;Alabama;burden of illness;cancer care;Cancer Center Support Grant;Centers for Disease Control and Prevention (U.S.);Cervical Cancer Screening;Child;Communication;Communities;Comprehensive Cancer Center;Congresses;County;Data;design;Disparity;Dose;Ensure;evidence base;follow-up;Funding;Future;Goals;Government;Health;Health Insurance;high school;High School Student;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;implementation science;Incidence;Intervention;Knowledge;Link;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mentors;Middle School Student;mortality;National Cancer Institute;Nonprofit Organizations;operation;Parents;Population;premalignant;prevent;Preventive;primary outcome;programs;Provider;Public Health;Registries;Research;Rural;rural counties;school district;School Nursing;Schools;screening;Screening for cancer;Screening Result;Service provision;skills;social;social cognitive theory;Societies;Students;teacher;Testing;theories;tool;twelfth grade;Underinsured;United States National Institutes of Health;uptake;Vaccination;Vaccines;Woman;Women's Health;Work;World Health Organization

PROJECT_TITLE: Comprehensive Cancer Center Support Grant


NIH_SPENDING_CATS: Cardiovascular;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: The importance of mechanosensitive channels to human health is underscored by the association of many disease states with compromised mechanosensation, including atrial fibrillation, muscular degeneration, arrhythmias, polycystic kidney disease, and numerous neural diseases. Therefore, it is the goal of this work is to understand both generalizable and cell type specific roles of mechanosensation in regulating gene expression, cellular motility, and cell-to-cell communication.

PI_NAMEs: STRATMAN, AMBER NICOLE (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: 3-Dimensional;Affect;Arrhythmia;Astrocytes;Atrial Fibrillation;Biological;Biological Assay;blood pressure regulation;Cell Communication;cell motility;cell type;Cells;Communication;Communities;Complex;Data;Disease;Endothelial Cells;Environment;Equilibrium;Gene Expression;Goals;Health;Human;In Vitro;Individual;intercellular communication;interest;Ions;Knowledge;Morphogenesis;Movement;Muscle;neural;Normal tissue morphology;Osmosis;Pattern;Play;Polycystic Kidney Diseases;programs;Proteins;Regulation;Research;Role;Second Messenger Systems;Signal Transduction;Smooth Muscle Myocytes;Stretching;Tissue Model;Tissues;Touch sensation;Transcriptional Activation;Work;zebrafish development

PROJECT_TITLE: Mechanosensitive mechanisms regulating cellular coordination during tissue morphogenesis and patterning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Diabetes;Kidney Disease;Nutrition;Obesity;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative: Youth-onset type 2 diabetes (T2D) typically manifests during or shortly after puberty and is characterized by a greater frequency and severity of diabetic kidney disease compared to adult-onset T2D and type 1 diabetes of similar duration. Puberty is recognized to accelerate kidney injury in youth with obesity and diabetes and may explain the magnified risk of diabetic kidney disease in youth-onset T2D, yet the pubertal mechanisms contributing to kidney injury in obesity and youth-onset T2D are unknown. The accelerated longitudinal study proposed in this application seeks to address these substantive gaps in knowledge.

PI_NAMEs: BJORNSTAD, PETTER  (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Acceleration;Address;Adolescent;Adult;Biological Markers;Carrier Proteins;Cessation of life;Charge;Complex;Complication;Conceptions;Continuous Glucose Monitor;Data;design;Development;Dextrans;Diabetes Mellitus;Diabetic Nephropathy;Diagnosis;Dialysis procedure;Distress;Energy Metabolism;Enrollment;epidemiologic data;Evaluation;Exhibits;experience;Experimental Designs;follow-up;Frequencies;Functional Magnetic Resonance Imaging;girls;Glomerular Filtration Rate;Glucose tolerance test;Glycosylated hemoglobin A;Gonadal Steroid Hormones;Growth;Growth Factor;Health;Heart;Height;hemodynamics;high risk;high risk population;Hyperglycemia;IgG4;imaging modality;Immunoglobulin G;Impairment;Injury to Kidney;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;intravenous glucose tolerance test;Iohexol;Kidney;Kidney Diseases;kidney dysfunction;Knowledge;lifetime risk;Link;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;Measurement;Metabolic;Metabolism;metabolomics;Methods;Mitochondria;Modeling;modifiable risk;multidimensional data;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;obesity development;organ growth;organ injury;Oxygen;Oxygen Consumption;Pathogenesis;Phenotype;Physiological;Physiological Processes;Physiology;Prediabetes syndrome;Predisposition;premature;preservation;Puberty;Renal function;renal hypoxia;Renal Plasma Flow;reproductive;Research Design;Risk;Risk Factors;Severities;Somatotropin;Structure;therapeutic target;Tissues;type I and type II diabetes;Weight maintenance regimen;Youth

PROJECT_TITLE: Puberty, diabetes, and the kidneys, when eustress becomes distress

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Neurosciences;Pain Research

ORG_CITY: ANN ARBOR

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The overall goal of the proposed University of Michigan (UM) HEAL National K12 Clinical Pain Career Development Program (UM-HCPDP) is to develop a national training program for early career clinician- scientists so as to grow the next generation of clinical pain research scholars. This national K12 program develops guidelines for career development and mentoring in clinical pain research, and coordinates training for scholars across institutions and mentorship teams, and with the Coordinating Center for National Pain Scientists Program (CCNPS). The UM-HCPDP seeks to train clinician-scientists with a deep understanding of pain mechanisms, non-opioid treatment options, scientific methodological rigor, leadership, patient-centric perspectives, and compassion for those who are suffering. This supplement seeks to expand the number and diversity of clinical pain research scholars entering the field of pain research.

PI_NAMEs: CLAUW, DANIEL J;HARTE, STEVEN EDWARD;WILLIAMS, DAVID A (contact)

PROGRAM_OFFICER_NAME: SYPEK, ELIZABETH IRENE

PROJECT_TERMS: Address;Administrative Supplement;Award;career development;Caring;clinical pain;cohort;Funding;Goals;Helping to End Addiction Long-term;Mentored Clinical Scientist Development Program;Michigan;novel;Pain;Pain Research;parent project;Parents;Program Development;Qualifying;Science;Scientist;skills;Training;training opportunity;Universities

PROJECT_TITLE: University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP)


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health;Urologic Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This application is being submitted by the Mayo Clinic Comprehensive Cancer Center (MCCCC) in response to the request for an extension of the “Administrative Supplements for the NCI P30 Cancer Center Support Grants for Multi-Channel Communication Campaigns”. The primary goal of the extension will continue efforts for the implementation, sustainability, and evaluation of the MICEO initiatives across the MCCCC enterprise focusing on: Black men (prostate cancer), Hispanic adults (colorectal and liver cancers), rural-residing adults (lung and colorectal cancers), and expansion to include Sexual and Gender Minority health. This extension will enable us to further our assessment of the impact of multi-channel communication campaigns targeting Black, Hispanic, Rural and sexual and gender minority populations on cancer prevention, control, and survivorship (CaPCaS).

PI_NAMEs: WILLMAN, CHERYL LYNN (contact)

PROGRAM_OFFICER_NAME: PTAK, KRZYSZTOF

PROJECT_TERMS: Administrative Supplement;Adult;Advocate;aged;Arizona;black men;Black Populations;Black race;Cancer Advocacy;cancer care;Cancer Center;Cancer Center Support Grant;cancer education;cancer prevention;Catchment Area;Church;Clinic;Colorectal Cancer;Communication;Communities;community engagement;Community Health;Community Outreach;Comprehensive Cancer Center;Continuity of Patient Care;Education;effectiveness evaluation;Evaluation;Event;Faith-based organization;farmers markets;Florida;Fostering;Funding;gender minority group;gender minority health;General Population;Goals;handbook;Health Educators;Health Fairs;Health Personnel;Health system;Hispanic;Hispanic Populations;Hybrids;improved;Institution;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;Midwestern United States;Outcome;Personal Communication;Printed Media;programs;Publishing;response;Rural;Rural Minority;Rural Population;Science;Sexual and Gender Minorities;sexual minority group;Spanish/English;survivorship;symposium;Target Populations;Training;Underserved Population;virtual;Virtual Tool

PROJECT_TITLE: Mayo CCCG (Supp) - Impact of Multi-Channel Communication Campaigns on Cancer Prevention, Control and Survivorship (CaPCaS) in Black, Hispanic, Rural, and Sexual and Gender Minority Populations


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Humans have developed mechanisms to restrict bacterial access to metals during infection, and thus, pathogens in turn have evolved high-affinity metal acquisition systems to overcome this restriction. This project will identify the mechanisms used by Yersinia pestis to acquire zinc in order to cause the human disease plague. As metal acquisition is essential for virulence, defining these mechanisms will reveal novel targets for the development of new anti-plague therapeutics.

PI_NAMEs: LAWRENZ, MATTHEW B (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: 3-Dimensional;Affinity;Attenuated;Bacteria;Binding;Bubonic Plague;Cells;Characteristics;Chemicals;combat;Crystallography;Data;Defect;Development;Drug Targeting;efflux pump;fitness;Foundations;Goals;Gram-Negative Bacteria;Hemochromatosis;Human;human disease;Immune response;improved;In Vitro;Infection;inhibitor;innovation;Iron;Kinetics;Lead;Leukocyte L1 Antigen Complex;Leukocytes;Mammals;Mediating;Membrane;Metals;Modeling;Molecular;mouse model;Mus;Mutagenesis;mutant;neutrophil;novel;novel therapeutic intervention;novel therapeutics;Nutritional Immunity;pathogen;pathogenic bacteria;permease;Plague;Pneumonic Plague;Predisposition;Prevention;Proteins;Pump;rational design;receptor;Research Personnel;response;Role;Siderophores;Solid;Specificity;System;Testing;Therapeutic;therapeutic candidate;therapeutic target;Time;transposon sequencing;Virulence;Virulence Factors;Work;Yersinia pestis;yersiniabactin;Zinc

PROJECT_TITLE: Iron independent role for yersiniabactin in Yersinia pestis

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Hematology;Rare Diseases

PHR: Project Narrative  Bone lesions from a variety of pathologies, including multiple myeloma, can occur anywhere in the skeleton, cause pain and spinal cord compressions, leading to pathologic fractures and paralysis, thereby diminishing the patient's quality of life. We propose to develop and evaluate an efficient whole-body magnetic resonance imaging (WBMRI) technology that can accurately identify these lesions and measure their response to treatment. This will provide relevant clinical information for treatment decisions to positively impact patients' quality of life and overall survival.

PI_NAMEs: MADHURANTHAKAM, ANANTH J (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Abdomen;Address;Anatomy;bone;bone imaging;bone loss;Bone Marrow;Bone marrow biopsy;Bone Marrow Transplantation;Chest;Clinical;clinical practice;clinical translation;Clinical Trials;clinically relevant;contrast enhanced;cost;cost effective;Detection;Development;Diagnosis;Diagnostic;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;experience;Fatty acid glycerol esters;fluorodeoxyglucose positron emission tomography;Generations;Goals;Image;Image Enhancement;imaging biomarker;imaging detection;imaging modality;Imaging Techniques;Imaging technology;improved;in vivo;Industry Standard;innovation;Lesion;Limb structure;Liquid substance;Localized Lesion;Location;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Marrow;Measurement;Measures;Metastatic Neoplasm to the Bone;Methods;Morphologic artifacts;Motion;Multiple Myeloma;Musculoskeletal;Neoadjuvant Therapy;neoplastic cell;next generation;Non-Malignant;novel;Outcome;Pain;Paralysed;Pathological fracture;Pathology;Patient Care;Patients;pediatric patients;Pelvis;Performance;Perfusion;PET/CT scan;Prognosis;Prognostic Marker;Progression-Free Survivals;Protocols documentation;Quality of life;Recommendation;Reference Standards;Renal Carcinoma;Resolution;Roentgen Rays;Scanning;Signal Transduction;Skeleton;Solid Neoplasm;spinal cord compression;standard of care;Testing;Time;treatment response;tumor;Vertebral column;Visualization

PROJECT_TITLE: Next-Generation Whole-Body MRI for Detection and Assessment of Therapy Response in Bone Lesions

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Narrative Support and Training for Research Independence, Diversity, and Equity (STRIDE) will launch a new phase of training navigation for infrastructure and support for all Early Stage Researchers (ESRs), particularly those who are underrepresented and engaged in cancer disparities research. American Indian populations in Minnesota have a high incidence of lung and liver cancers with very limited participation in health systems for cancer treatments and limited representation in cancer careers and research. STRIDE efforts will focus on researcher preparation for competitive cancer research studies and collaborations that are established with trust, community support, and leverage the assets of the Masonic Cancer Center.

PI_NAMEs: MILLER, JEFFREY S. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Alaska Native;American Indian Population;American Indians;anti-cancer research;Applications Grants;Cancer Center;cancer health disparity;cancer therapy;career;career development;Collaborations;Communication;Communities;Education;Equity;equity, diversity, and inclusion;Event;experience;Funding Opportunities;Goals;Health Professional;Health system;Incidence;Infrastructure;interest;Learning;Lived experience;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;meetings;member;Mentors;Minnesota;minority health;outreach;peer;peer networks;peer support;Phase;Preparation;Process;programs;Research;research and development;Research Personnel;Research Proposals;research study;Research Support;Research Training;Resource Development;Resources;Source;Students;success;Time;tool;Training;Training Programs;Trust;Work


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PI_NAMEs: ESSER-KAHN, AARON  (contact)

PROJECT_TERMS: Adaptive Immune System;Adjuvant;Agonist;Animal Model;Antigens;Award;B-Lymphocytes;Cells;Contractor;FDA approved;Human;human disease;Immune;immunogenicity;Immunologic Memory;Inflammation;influenza virus vaccine;inhibitor;innate immune pathways;Innate Immune System;Libraries;novel;pathogen;Pathway interactions;Preventive vaccine;Research;response;T-Lymphocyte;Testing;therapeutic vaccine;vaccine efficacy;vaccine response;Vaccines

PROJECT_TITLE: Discovery of adjuvants via novel modulation of innate immune pathways for vaccines against influenza


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: The most recent conflicts are creating a new generation of veterans, including an increasing number of women veterans, who present with comorbid PTSD and chronic pain conditions, including Fibromyalgia (FM), from deployment-related physical injuries and exposure to psychological trauma. Health behavior change is important in treating these conditions and proactively preventing long-term negative health sequelae, in order to benefit these veterans directly and reduce the challenges to our healthcare system. The proposed SPiRE application will use an innovative translational research approach to study whether a progressive -based exercise program will reduce FM pain in patients with PTSD and to elucidate and modify potential PTSD- related deficiencies in neurobiological and psychological responses to exercise to optimize the physical and psychological benefits of exercise for these individuals.

PI_NAMEs: CHECKO (SCIOLI), ERICA ROSE (contact)

PROJECT_TERMS: actigraphy;Acute;Allopregnanolone;American;Anhedonia;Anti-Inflammatory Agents;antinociception;behavior change;Biological Markers;Boston;Cardiology;Cardiopulmonary;Chronic;chronic musculoskeletal pain;chronic pain;chronic painful condition;Clinical Research;clinically significant;Cognitive;college;comorbidity;cytokine;Data;depressive symptoms;design;Development;disability;Disease;Educational Intervention;Exercise;exercise adherence;exercise intervention;exercise physiologist;exercise prescription;exercise program;exercise regimen;Exercise Test;exercise training;experience;Exposure to;Fibromyalgia;fibromyalgia pain;fibromyalgia patients;follow-up;Fostering;Functional disorder;Funding;Generations;Grant;Guidelines;Health;Health behavior change;Health Benefit;health care service utilization;Healthcare Systems;Heart Rate;Home;Hormones;Hydrocortisone;IL8 gene;immunoregulation;improved;Individual;Inflammation;Inflammatory;Injury;innovation;Interleukin-6;Intervention;intrinsic motivation;Maintenance;Mental Depression;Mental Health;Modification;Monitor;Motivation;neurobiological mechanism;Neurobiology;Neurohormones;Neuromodulator;neuropeptide Y;neurosteroids;Pain;pain reduction;pain sensitivity;Pain Threshold;Participant;Patients;physical conditioning;Physiological;Population;Post-Traumatic Stress Disorders;Pregnanolone;prevent;Problem Solving;Process;Protocols documentation;psychologic;psychological trauma;Publishing;recruit;Research Design;response;Rewards;Running;Self Efficacy;Severities;Stress;Substance P;Symptoms;System;Telephone;Testing;Training;Training Programs;Translational Research;trauma exposure;Treatment Protocols;United States National Institutes of Health;Up-Regulation;Veterans;Walking;Woman;Work

PROJECT_TITLE: Neurobiological and Psychological Benefits of Exercise in Fibromyalgia and PTSD

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: Previous studies suggest that Veterans with a leg amputation who use a prosthesis have impaired physical function, which could increase the risk of osteoarthritis, leg/back pain, and diabetes/obesity. The alignment of a lower limb prosthesis, which is the orientation of prosthetic components with respect to the socket, affects the risk of secondary injury and physical function of Veterans with leg amputation. Currently, there are no objective methods to assess prosthetic alignment in Veterans with a leg amputation. Thus, we will develop an accurate, precise, and cost-efficient measurement method to objectively [assess] prosthetic alignment in a clinical setting. In the long term, [this approach could be used to investigate the relationship between prosthesis alignment and comfort, secondary injury risk, and quality of life in Veterans with lower limb amputation. We ultimately aim to advance measurement technology and rehabilitation to reduce discomfort and improve the physical function and quality of life of Veterans with an amputation.]

PI_NAMEs: GRABOWSKI, ALENA  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Activities of Daily Living;Affect;Algorithms;Amputation;Applications Grants;Back Pain;Biological;Biomechanics;Clinical;Consumption;cost;cost efficient;Data;Degenerative polyarthritis;Development;Diabetes Mellitus;experience;foot;Frequencies;functional independence;Goals;Hip Osteoarthritis;improved;indexing;Individual;Injury;Knee Osteoarthritis;Leg;Length;limb amputation;Limb Prosthesis;Lower Extremity;Machine Learning;Measurement;Measures;Methods;Motion;novel;Obesity;Outcome;Persons;Physical Function;physical impairment;predictive modeling;Process;Prosthesis;prosthesis wearer;prosthetic alignment;prosthetic foot;Quality of life;Reaction;reconstruction;Rehabilitation therapy;Reporting;Research;Risk;Risk Reduction;sensor;sensor technology;System;Technology;Time;tool;treadmill;United States;Veterans;Visit;Visual;Walking;wearable sensor technology;wireless;wireless sensor

PROJECT_TITLE: Use of Wearable Sensors to Assess Prosthetic Alignment in Veterans with Unilateral Transtibial Amputations


ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: Narrative Osteoarthritis (OA) is a prevalent condition that compromises activities of daily living and has few treatment options that preserve the joint. To address this limitation, this proposal extends and applies our progress in functional cartilage tissue engineering to address the `holy grail' of biologic joint resurfacing by fabricating and testing, in a large animal model, a stem cell-based replacement for the majority of the load bearing surface of the medial femoral condyle. Once validated in this pre-clinical model, this technology can be extended to other, more complex joint surfaces throughout the body. Our goal is to eliminate the need for replacement with metal and plastic and alleviate the serious implications of OA in the Veteran population, and in society as a whole.

PI_NAMEs: MAUCK, ROBERT L;STEINBERG, DAVID  (contact)

PROJECT_TERMS: 3D Print;Activities of Daily Living;Address;Affect;aged;Anatomy;Animal Model;Animals;Arthritis;articular cartilage;Articular Range of Motion;Autologous;Benchmarking;Biochemical;Biological;Biological Assay;Biological Models;Biological Process;Biology;Biomedical Engineering;bone;Cartilage;Cartilage injury;cartilage repair;Clinical;clinical practice;clinical translation;Clinical Trials;clinically relevant;comorbidity;Complex;contrast enhanced;Coupled;Custom;Data;Degenerative polyarthritis;Deposition;Disabling;efficacy testing;Engineering;Evaluation;experimental study;Extracellular Matrix;fabrication;Femur;Fluoroscopy;functional outcomes;Funding;Generations;Geometry;Goals;Growth;healing;Hip Osteoarthritis;Histologic;Human;Hyaluronic Acid;Hydrogels;Image;Implant;implantation;In Vitro;in vivo;Inflammation;Inflammatory;Injury;Intervention;joint biomechanics;joint function;joint injury;joint loading;Joints;Knee;Knee joint;Knee Osteoarthritis;Life Expectancy;mechanical properties;Mechanics;Medial;Meniscus structure of joint;Mesenchymal Differentiation;Mesenchymal Stem Cells;Metals;Methods;microCT;military veteran;Miniature Swine;Modeling;Molds;Motion;novel;Operative Surgical Procedures;osteochondral tissue;Outcome;Outcome Measure;Patients;Population;pre-clinical;Pre-Clinical Model;preservation;Property;Prosthesis;Quality of life;Reaction;Replacement Arthroplasty;sample fixation;Sampling;scaffold;Second Look Surgery;Services;Societies;stem cells;Stress;success;supportive environment;Surface;Surgical Management;Symptoms;System;Techniques;Technology;Testing;Time;Tissue Engineering;Tissues;Translating;transmission process;Traumatic Arthropathy;Veterans;Weight-Bearing state;Work

PROJECT_TITLE: Knee Joint Resurfacing with Anatomic Tissue Engineered Osteochondral Implants

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Incontinence associates with military service and post-traumatic stress disorder in both male and female Veterans. Neurogenic detrusor overactivity (NDO) is caused by spinal cord injury or disorder, or peripheral neurodegenerative conditions, and causes urine leakage at low volumes. NDO is disproportionately experienced by Veterans treatment effectiveness varies greatly between individuals. This project will demonstrate the feasibility of a new type of nerve stimulation—triggered sacral neuromodulation—to treat NDO in Veterans. A wireless bladder sensor will be inserted into the bladder to transmit a feedback signal enabling stimulation from a percutaneous lead. The wireless sensor will also measure NDO symptoms during simulated activities of daily living without catheters. Catheter-free detection of bladder activity will improve the outcomes of neuromodulation evaluations for Veterans with NDO. Future work could use the triggered neuromodulation system to study other methods of nerve stimulation to treat bladder, bowel, or sexual dysfunction.

PI_NAMEs: MAJERUS, STEVE  (contact)

PROJECT_TERMS: Activities of Daily Living;Affect;Algorithms;Autonomic Dysreflexia;Awareness;Behavior;Bladder;botulinum neurotoxin injection;Catheters;classification algorithm;Clinical;comorbidity;Computer software;Custom;Data;data exchange;decubitus ulcer;Detection;detection method;Diabetic Neuropathies;diaries;Disadvantaged;Disease;Effectiveness;Elderly;Evaluation;Event;experience;Extravasation;fall risk;Feasibility Studies;Feedback;Female;first-in-human;Frequencies;functional decline;Future;Goals;Home;Hour;Human;implantation;improved;improved outcome;Incontinence;Independent Living;Individual;Intestines;Kidney Failure;Label;Lead;Major Depressive Disorder;male;Measures;men;Meta-Analysis;Methods;military service;Modeling;Multiple Sclerosis;Nerve;Nerve Degeneration;neuroregulation;Outcome Measure;Parkinson Disease;Peripheral;Phase;Post-Traumatic Stress Disorders;pressure;Questionnaires;Radio;Rattus;Readiness;Reflux;Refractory;Reporting;Research;Research Project Grants;response;Risk;sensor;Sepsis;Sexual Dysfunction;Sheep;Signal Transduction;Social isolation;Spinal cord injury;Stroke;Symptoms;System;Technology;Testing;Time;tool;translational goal;Translational Research;Translations;transmission process;Treatment Effectiveness;treatment response;urinary;Urinary Incontinence;Urinary Retention;Urinary tract infection;Urine;Urodynamics;Veterans;wireless;wireless communication;wireless sensor;wireless transmission;Woman;Work

PROJECT_TITLE: Triggered sacral neuromodulation to treat neurogenic detrusor overactivity based on algorithmic classification of bladder filling status from wireless pressure data.

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


FUNDING_MECHANISM: OTHERS

PHR: Dr. Kirsch’s research activities focus on restoring shoulder, arm, and hand movements to individuals with extensive paralysis due to spinal cord injury (SCI). SCI is a devastating condition that often causes significant disability and loss of independence. There are approximately 296,000 individuals in the United States with a SCI, at least 42,000 of whom are Veterans eligible for VA care. Dr. Kirsch has used functional electrical stimulation to elicit contractions in paralyzed muscles that can power movements, and novel control methods to coordinate these muscle contractions to generate functional movements. He has also examined cutting edge “brain computer interface” techniques to give the users of such a system the ability to intuitively command the desired movements of the upper limb. Dr. Kirsch is also very active in “translational research” programs that assist researchers in developing their laboratory discoveries into products that improve the independence and overall health of Veterans.

PI_NAMEs: KIRSCH, ROBERT F. (contact)

PROJECT_TERMS: Academia;Activities of Daily Living;Address;Algorithms;American;Amputees;Anatomy;Area;arm;arm movement;artificial intelligence method;Biomedical Engineering;Brain;brain computer interface;brain health;career;Caring;Cervical;Cervical spinal cord injury;Characteristics;Clinical;combat injury;Communities;design;Development;disability;Doctor of Philosophy;Education;Elbow;Electrodes;Eligibility Determination;Engineering;Faculty;first-in-human;functional electrical stimulation;functional restoration;Funding;Hand;Health;Healthcare;Human;Human Resources;improved;Incidence;Individual;Injury;Intervention;Intuition;Journals;K-Series Research Career Programs;Laboratories;Leadership;Learning;Medical;member;Mentors;Methods;Military Personnel;Modeling;Movement;Muscle;Muscle Contraction;Muscle function;Musculoskeletal;Neck;Nerve;Nervous System Disorder;neural;neural implant;neural network;neuroregulation;neurorestoration;neurotechnology;novel;Orthotic Devices;Pain;Paralysed;Participant;Pattern;Persons;Population;programs;Prosthesis;prosthesis control;Proxy;Psychological reinforcement;Publications;Quadriplegia;rehabilitation research;Rehabilitation therapy;Research;Research Activity;research and development;Research Personnel;Research Project Grants;restoration;Role;Scientist;Seminal;Series;Services;Shoulder;Signal Transduction;simulation;Skeletal Muscle;Spinal Cord;Spinal cord injury;Study Section;symposium;System;Techniques;Training;Translational Research;translational research program;Translations;undergraduate student;United States;United States National Institutes of Health;Universities;Upper Extremity;Upper limb movement;Veterans;Work

PROJECT_TITLE: RR&D Research Career Scientist Application

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Contact PD/PI: Mulder, Nicola Project Narrative The ODSP will develop a flexible, scalable open data science platform for the DSI-Africa consortium to find and access data, select tools and workflows and run analyses on a choice of computing environments, all through easy to use workspaces. Administration and support of the core resources and consortium activities will be coordinated by the CC. Together, the ODSP and CC will provide an infrastructure for researchers to use data science technologies to deliver cutting edge biomedical research for health, while promoting cohesion, collaborative cross-consortium activities and engagement with external stakeholders to facilitate innovation and translation. Project Narrative Page 113

PI_NAMEs: MULDER, NICOLA  (contact);SKELTON, MICHELLE

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Address;Africa;African;Agreement;Biomedical Research;cohesion;Computational Biology;Data;data access;Data Analyses;data management;Data Science;Data Set;Data Storage and Retrieval;data submission;Deposition;Development;Educational workshop;Elements;Ensure;Environment;Event;experience;flexibility;Health;Industry;Informatics;Infrastructure;innovation;Joints;Methods;novel;open data;Organizational Efficiency;Outcome;Participant;Policies;Privatization;Research;Research Personnel;Resource Informatics;Resources;Running;Scientist;Techniques;Technology;tool;tool development;Training Programs;Translations;Universities;website development

PROJECT_TITLE: eLwazi Open Data Science Platform and Coordinating Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE - Overall Innovative safe and effective new treatments are needed to improve the lives of people living with kidney diseases. The development of tissue chips provides a path forward to improve the drug development pipeline. The overall goal of the University of Washington Translational center for kidney microphysiological systems to improve drug safety and efficacy is to expand upon already completed work, in order to qualify these systems as useful drug development tools.

PI_NAMEs: FREEDMAN, BENJAMIN SOLOMON;HIMMELFARB, JONATHAN  (contact);KELLY, EDWARD J

PROGRAM_OFFICER_NAME: HARGROVE, PASSLEY R

PROJECT_TERMS: absorption;Accounting;Affect;Animal Model;Architecture;Biology;biomarker discovery;biomarker evaluation;Biomedical Engineering;Biomedical Research;Biometry;Blood Vessels;Cause of Death;Cell Physiology;Cellular biology;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;commercialization;Complex;Computational Biology;data modeling;design;Development;differentiation protocol;Disadvantaged;Disease;disease model;drug development;drug efficacy;effective therapy;Engineering;Epithelial Cells;Etiology;Expenditure;Failure;Functional disorder;Funding;gene editing technology;Genomics;glomerular filtration;Goals;Health;Histologic;Human;Image;improved;In Vitro;in vitro Model;induced pluripotent stem cell;innovation;Internal Medicine;Intervention;Investigation;Kidney;Kidney Diseases;kidney vascular structure;materials science;medical specialties;Medicare;medication safety;Microfluidics;microphysiology system;Modeling;Modernization;Molecular;Molecular Biology;multidisciplinary;Nephrons;novel therapeutics;organ on a chip;Organoids;Pathology;Persons;Pharmaceutical Preparations;Pharmacology and Toxicology;Phase;Phenotype;Physiological;Physiological Processes;Physiology;precision medicine;Process;protocol development;Public Health;Publishing;Qualifying;Quality Control;randomized, clinical trials;Reference Standards;Renal function;response;response to injury;stem cell biology;Structure;Study models;System;Technology;Testing;Therapeutic;Tissue Microarray;tool;tool development;Toxic effect;Translating;Tubular formation;United States National Institutes of Health;Universities;Washington;Work


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Eating Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

PI_NAMEs: HAZZARD, VIVIENNE M (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Accounting;Adolescence;Adolescent;Adolescent obesity;Adult;Affect;Area;Award;Behavior;Beverages;Binge Eating;Body mass index;career;Child;cohort;community setting;Data;Development;Dietary Factors;Dietitian;Eating;Energy consumption;Etiology;excessive weight gain;experience;Feedback;Feeling;Food;food insecurity;food security;Funding;General Population;Goals;healthy weight;high body mass index;Household;human centered design;implementation intervention;improved;Intervention;Interview;Knowledge;Longitudinal Studies;Machine Learning;marginalized population;Mediating;Mediation;Mediator;Mental Health;Mentors;Mentorship;Methods;Morbidity - disease rate;Nutrient;Obesity;obesity prevention;obesity risk;Pathway interactions;Pattern;Phase;physical conditioning;Premature Mortality;Prevalence;prevent;Public Health;Qualitative Research;recruit;Reporting;Research;Research Personnel;Resources;response;Risk;Risk Factors;Role;Statistical Methods;Strategic Planning;Structure;Techniques;Testing;therapy design;therapy development;Time;Training;Trees;United States;United States National Institutes of Health;Weight;Weight Gain;Work;young adult

PROJECT_TITLE: Binge Eating as a Mechanism Underlying the Food Insecurity-Obesity Paradox in Adolescents

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE: An innovative, multi-channel outreach and educational campaign to increase cancer awareness, preventive behaviors, and lifesaving screenings can help address cultural issues contributing to disparities in health literacy and cancer outcomes in American Indian communities in North Carolina. Utilizing an equity-centered health communication process will help ensure messaging is clear, relatable, actionable, and inclusive as part of a sustainable communication campaign with the opportunity for future dissemination, adaptation, and implementation.

PI_NAMEs: MESA, RUBEN A. (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Address;American Indian community;American Indian Population;American Indians;Awareness;Baptist Church;Behavior;Cancer Burden;cancer education;Catchment Area;Cause of Death;Collaborations;Colorectal Cancer;Communication;Communities;community engagement;Community Health Education;Community Outreach;Comprehensive Cancer Center;Development;Diagnosis;Disparity;Education and Outreach;Educational Intervention;Ensure;Equity;Ethnic Population;Evaluation;Future;Health;health communication;health disparity;health literacy;Heart Atrium;improved;Infrastructure;innovation;Life;lung cancer screening;Malignant Neoplasms;Media Campaign;Mission;Mississippi;mortality;North Carolina;Outcome;Outcome Measure;Preventive;Process;racial population;reduce tobacco use;screening;Smoking;social media;tribal community;Tribes

PROJECT_TITLE: Communication in American Indians thru Strategies for Equity 4 Cancer (CASE4Cancer)


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HOUSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PI_NAMEs: ZHENG, YE  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Acute Lymphocytic Leukemia;Address;Agreement;Architecture;Biological;Biological Assay;Blood Component Removal;brain cell;brain tissue;CAR T cell therapy;Cell Line;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chimeric antigen receptor T cells;Chromatin;Chromatin Structure;CISH gene;computer framework;Computer software;computerized tools;Data;Development;Distal;DNA;Elements;Enhancers;epigenome;epigenomic profiling;epigenomics;Foundations;Frequencies;Gene Expression;Gene Expression Regulation;Genes;Genome;genome-wide;genomic data;Genomics;Goals;Hi-C;histone modification;Histones;Human;human data;Immunotherapy;Individual;insight;Investigation;Joints;leukemia/lymphoma;Machine Learning;machine learning framework;machine learning model;Maps;Membrane Proteins;Methods;Modality;Modeling;Molecular Conformation;multimodality;multiple omics;Mus;Neighborhoods;novel;Organ;patient response;Patients;Peripheral Blood Mononuclear Cell;Polycomb;programs;promoter;Regulation;Regulatory Element;Repression;Resolution;Role;Sampling;Signal Transduction;Signaling Protein;single cell technology;single-cell RNA sequencing;Specific qualifier value;statistical learning;Statistical Models;Structure;System;T cell response;Technology;Three-dimensional analysis;Tissues;tool;transcriptome;transcriptomics;treatment response;unsupervised clustering;Variant

PROJECT_TITLE: Bridging the gap: joint modeling of single-cell 1D and 3D genomics


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  Fluorinated drugs, accounting for 29% of all 276 Type 1 FDA new drug approvals between 2011-2019,  demonstrate the growing importance of fluorine-18 labeled molecules in PET applications. By merging  radiochemistry with organometallic chemistry, this proposal aims to meet the demand for aromatic fluorine 18 radiomedicines. The development of new metal-mediated and metal-free late-stage radiolabeling methods  can significantly expedite the production of fluorine-containing molecules, particularly those of high  commercial importance.

PI_NAMEs: WRIGHT, JAY SAMUEL (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Accounting;Adoption;Agrochemicals;American;Amides;Animals;Award;Binding;Biodistribution;bioimaging;Biological Assay;biomedical imaging;Buffers;Chemicals;Clinical;clinical translation;Clinical Trials;cost;Data;design;Detection;Development;diagnostic development;Disease;disease diagnostic;Disease Progression;Dose;Drug Costs;drug development;Drug Industry;Drug Targeting;Elements;Fluorine;functional group;Goals;Good Manufacturing Process;Guidelines;Health Care Costs;Healthcare;High Pressure Liquid Chromatography;Human;Image;imaging agent;imaging modality;imaging scientist;imaging study;Imaging technology;improved;In Vitro;in vivo;insight;invention;Label;Liver;Manuals;Marketing;Mediating;Metabolic;Metabolism;Metals;Methodology;Methods;microPET;Microsomes;Mission;Molecular;Molecular Bank;Molecular Structure;Monitor;NADP;National Institute of Biomedical Imaging and Bioengineering;Neurologic;New Drug Approvals;novel therapeutics;nuclear imaging;Organometallic Chemistry;patient population;Patient-Focused Outcomes;Patients;Pennsylvania;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Positron-Emission Tomography;predict clinical outcome;Preparation;Prevention;Procedures;Production;programs;Property;Protocols documentation;quality assurance;Radio;Radioactive;Radioactivity;radiochemical;Radiochemistry;Radioisotopes;Radiolabeled;Radiopharmaceuticals;Reaction;Reproducibility;Research;Research Proposals;Rodent;Role;Safety;scaffold;Serum;Signal Transduction;Solvents;stable isotope;success;Technology;Therapeutic;Time;Toxic effect;Tracer;Translations;Universities;Validation;Zinc

PROJECT_TITLE: Metal-Mediated C-H Radiofluorination for Rapid Access to PET Imaging Agents


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Obesity;Pain Research;Patient Safety;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Precision Medicine;Rehabilitation

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: PROJECT NARRATIVE The proposed study will convene cuffGEN, the largest consortium to date, to study the genetics of imaging- confirmed rotator cuff tears and fatty infiltration, which lead to shoulder pain and disability. In addition to identifying high-risk individuals with genetic variants associated with rotator cuff tear and fatty infiltration, the study prioritizes gene discovery by incorporating gene expression information and assesses causality between obesity and fatty infiltration. Data from this study can also help identify individuals for whom treatments are most likely to be successful based on their genetic profile.

PI_NAMEs: JAIN, NITIN B (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Adipose tissue;aged;American;Arthroscopic Surgical Procedures;biobank;Body mass index;case control;Case/Control Studies;causal variant;Cell Death;Classification;Clinical Trials;Code;cohort;Collaborations;Data;Databases;Decision Making;Defect;Diagnostic;disability;Disease;Elbow;Electronic Health Record;electronic health record system;Etiology;Fatty acid glycerol esters;Fiber;follow-up;Functional disorder;Funding;gene discovery;Gene Expression;Gene Targeting;Genes;Genetic;genetic epidemiology;Genetic Predisposition to Disease;genetic profiling;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic locus;Genotype;Genotype-Tissue Expression Project;high risk population;Image;imaging genetics;Impairment;improved;Individual;Infiltration;Infrastructure;Intervention;Investigation;Link;Magnetic Resonance Imaging;Measures;Medical Records;Mendelian randomization;Muscle;Nutrient;Obesity;Observational Study;Operative Surgical Procedures;optimal treatments;Outcome;Pain;Patient Outcomes Assessments;Patients;Persons;Phenotype;Physical therapy;Physicians;Population Control;Prediction of Response to Therapy;Randomized;Readiness;recruit;Rehabilitation therapy;Research;Research Design;Research Personnel;Risk;Role;Rotator Cuff;rotator cuff tear;Sampling;Shoulder;Shoulder Pain;Single Nucleotide Polymorphism;Site;Standardization;statistics;Structure;Surgeon;Symptoms;systematic review;Tendinopathy;Tendon structure;Testing;transcriptome;Trauma;Treatment outcome;United States;United States National Institutes of Health;Utah;Variant;Visit;Weight

PROJECT_TITLE: The Genetic Epidemiology of Rotator Cuff Tears: The cuffGEN Study

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Not Applicable

PI_NAMEs: PASCHE, BORIS  (contact)

PROJECT_TERMS: Academy;Adherence;Administrative Supplement;African American;African Women;Area;Awareness;Black race;black women;Breast Cancer Detection;Businesses;Cancer Control;cancer education;Cancer health equity;cancer prevention;Catchment Area;Collaborations;Communication;Communities;community building;community collaboration;community engagement;community partners;Development;Funding;Health;improved;Individual;Intervention;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Marketing;member;metropolitan;Middle Eastern;North African;Outcome;Persons;Population;programs;psychoeducation;Schedule;screening;social media;Training;Underserved Population;Work

PROJECT_TITLE: P30 Administrative Supplement for Multi-Channel Communication Campaigns for Improvements in Cancer Education and Outcomes (MICEO) in Underserved Populations


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE Achieving better T2D self-management remains a challenge for socio-economically disadvantaged populations and immigrants. Adult Haitian immigrants with T2D have higher insulin resistance and A1c than other comparable racial/ethnic groups increasing their risk for morbidity and mortality. The proposed training plan and research study will focus on understanding the factors leading to Haitian immigrants’ increased risk for poor T2D outcomes and identify more specific targets for intervention.

PI_NAMEs: MAGNY-NORMILUS, CHERLIE  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Accelerometer;actigraphy;Address;Adherence;Adopted;Adult;Affect;African American population;Behavior;Biological Markers;Black Populations;Blood Glucose;Caring;Caucasians;Chronic;Classification;Communication;community engaged approach;comorbidity;Complement;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Cuban American;cultural health;Data;Death Rate;Dedications;Development;diabetes management;diabetes self-management;Diet;dietary;Discrimination;Disparity;Economically Deprived Population;Education;Educational Intervention;Environmental Risk Factor;Ethnic Population;Evaluation;Exercise;experience;family support;food insecurity;Glucose;glucose monitor;glycemic control;Glycosylated Hemoglobin;Goals;Habits;Haiti;Haitian;Health;health belief;health care disparity;health care service utilization;Health Services Accessibility;Health Status;Healthcare Systems;Healthy Eating;high risk;Hip region structure;Immigrant;improved;Individual;Insulin Resistance;Intervention;Interview;Investigation;Life Style;Linguistics;Literature;Masks;Measurement;Measures;medication compliance;meetings;Mentors;Methods;migration;Minority Groups;Morbidity - disease rate;mortality;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Patient Self-Report;perceived stress;Performance;Persons;Phase;Physical activity;pill;Pilot Projects;Population;programs;psychosocial;Psychosocial Factor;public health relevance;racial population;Randomized;Recommendation;Research;Research Design;research study;Research Support;Resources;response;Risk;Role;Self Management;Social Environment;sociodemographics;socioeconomic disadvantage;standard care;Stress;Surveys;Techniques;Time;Training;treatment planning;United States;Work

PROJECT_TITLE: Self-Management and Glycemic Control in Adult Haitian Immigrants with Type 2 Diabetes

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(77)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Siteman Cancer Center (SCC) is committed to overcoming structural barriers that have limited diversity and equity in academic medicine and the cancer research workforce. The overarching goal of the SCC initiative to Strengthen Research, Training, and Outreach Capacity is to provide personalized training navigation to link scholars to cancer research supports. SCC staff will collaborate to implement infrastructure and processes that increase: trainee awareness and use of shared cores and resources appropriate to their interests; identification of mentors; awareness of catchment priorities and cancer health inequities; and trainings including grant writing, scientific editing, and travel supports to advance the career development and trajectory of SCC trainees.

PI_NAMEs: EBERLEIN, TIMOTHY J (contact)

PROJECT_TERMS: access disparities;African American;anti-cancer research;Asian;Award;Awareness;Black American;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer health equity;career;career development;Career Mobility;Catchment Area;Categories;Climate;Clinical and Translational Science Awards;Clinical Sciences;Collaborations;Component of the Center for Cancer Research;County;design;Development;disabled;Distal;diversity and equity;Education;Educational workshop;Ensure;Equity;equity, diversity, and inclusion;experience;Faculty;Feedback;Geography;Goals;graduate school;Grant;Grant Review;health inequalities;high school degree;Hispanic;Illinois;improved;Incidence;Individual;Inequity;Infrastructure;Institution;interest;K-Series Research Career Programs;Latino;Link;Malignant Neoplasms;Medically Underserved Area;Medicine;member;Mentors;Mentorship;Mission;Missouri;mortality;NCI Center for Cancer Research;Outcome;outreach;Patient Self-Report;Population;Postdoctoral Fellow;Poverty;Preparation;Process;programs;Publishing;Race;racial population;recruit;Research;Research Personnel;Research Support;resilience;Resource Development;Resources;rural area;Science;Screening for cancer;Services;socioeconomics;success;symposium;tool;Training;Training Activity;Training and Education;Training Support;Translational Research;Travel;Universities;Washington;Woman;Work;Writing

PROJECT_TITLE: Cancer Center Support Grant


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Triple-negative breast cancer (TNBC) is considered the most aggressive subtype of breast cancer, and patients with TNBC exhibit a poor prognosis, despite current treatment regimens. Here, we seek to decipher a novel oncogenic function of TAZ on tumor microenvironment in TNBC progression and may provide opportunities for novel biomarker or therapeutic target discovery.

PI_NAMEs: ZHANG, JIANMIN  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: adaptive immune response;angiogenesis;B-Lymphocytes;Biological Markers;Biology;Breast Cancer Cell;breast cancer progression;Cancer Biology;cancer cell;cancer stem cell;Cell Proliferation;Cells;Cessation of life;Clinical;Complex;Cytometry;Data;Disease;Distant;Epidermal Growth Factor Receptor;epithelial to mesenchymal transition;Estrogen Receptors;Exhibits;Fibroblasts;follow-up;Genes;Genetic;Goals;high risk;Human;Immune;Immune response;Immune system;Immunocompetent;Immunosuppression;Implant;Incidence;Invaded;Knowledge;Laboratories;loss of function;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Molecular;molecular subtypes;mortality;mouse model;Mus;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic;neoplastic cell;neutrophil;new therapeutic target;novel;novel marker;novel therapeutic intervention;Oncogenic;overexpression;Pathway interactions;Patients;Play;Progesterone Receptors;Prognosis;prognostic;public health relevance;receptor;recruit;Recurrence;refractory cancer;Regulation;Regulatory T-Lymphocyte;Resistance;Role;Signal Pathway;Signal Transduction;T-Lymphocyte;targeted treatment;therapeutic target;trait;Transcriptional Coactivator with PDZ-Binding Motif;Transgenic Mice;Treatment Protocols;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;tumor progression;tumor-immune system interactions;Vascular Endothelial Cell

PROJECT_TITLE: TAZ-driven Regulation of Tumor Microenvironment in Triple-Negative Breast Cancer


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: CHARLESTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Choroidal neovascularization (CNV) is the most sight-threatening complication of age-related macular degeneration (AMD), and current therapies leave 50% of CNV patients legally blind at their therapeutic threshold. This proposal will identify a new class of therapeutics for CNV, which target newly identified mechanisms of disease, and have the potential to be more effective than existing interventions.

PI_NAMEs: PEARSALL, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Acetates;Address;Adoptive Transfer;Affect;Age;Age related macular degeneration;Age related pathologies;angiogenesis;Angiogenesis Inhibitors;Animals;Anti-Inflammatory Agents;Basic Science;Benchmarking;beta-Hydroxybutyrate;bevacizumab;Binding;Biological Assay;Blindness;Cadaver;Cell Respiration;Cell Separation;cell type;Cells;Choroid;Choroidal Neovascularization;Circulation;Clinical Research;Coculture Techniques;Complication;Coupled;Data;dietary;Disease;Elderly;Endothelial Cells;Exudative age-related macular degeneration;Eye;Flow Cytometry;Foundations;G-Protein-Coupled Receptors;Genes;Genetic Polymorphism;genome wide association study;Glycolysis;Immune;immunoregulation;In Vitro;Incidence;Infiltration;Inflammation;Inflammatory;Intervention;Invaded;Ketone Bodies;Ketones;Ketosis;Kinetics;Knockout Mice;Knowledge;Lasers;Left;Legal Blindness;legally blind;Lesion;Link;Liver;Macrophage;macula;Metabolic;Metabolism;Microglia;Modeling;monocyte;Natural Immunity;neovascularization;neutrophil;oxidized lipid;paracrine;Pathologic;Pathology;Patients;Peripheral;Phenotype;Play;Population;Process;programs;receptor;recruit;Retina;Risk;Role;Severities;single-cell RNA sequencing;standard of care;Testing;Therapeutic;Therapeutic Effect;therapy development;Treatment Efficacy;Vision;VLDL receptor;Work

PROJECT_TITLE: A new class of wet AMD therapeutics

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cancer;Radiation Oncology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: BIOLOGY

ORG_NAME: OAKLAND UNIVERSITY

PHR: NARRATIVE OF FUNDED R15 GRANT (R15CA254006-01A1) Immune cells from the bone marrow are known to migrate to tumors and play an important role ongoing tumor growth. Bone marrow-derived hematopoietic stem and progenitor cells are also present in tumors but their role in tumor activity is still unknown. This proposal will elucidate how hematopoietic stem and progenitor cells are maintained in tumors and identify the role they play in tumor progression and response to therapy. The long- term goals are to use findings to develop novel treatment strategies that overcome the pro-tumor effects of these stem cells resulting in better patient outcomes.

PI_NAMEs: MADLAMBAYAN, GERARD JAMES (contact);VILLA DIAZ, LUIS GERARDO

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: bone cell;Bone Marrow;Cell Maintenance;cell motility;Cells;Data;Development;Extracellular Matrix;Focal Adhesion Kinase 1;Funding;Goals;Growth;Hematopoietic stem cells;Immune;In Vitro;in vivo;Integrins;Investigation;Knowledge;Laminin;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;migration;novel;Patient-Focused Outcomes;Patients;Play;Population;Process;Radiation therapy;Recovery;Role;Signal Pathway;Signal Transduction;Solid Neoplasm;stem cell migration;stem cells;Testing;Time;treatment response;treatment strategy;tumor;Tumor Biology;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages

PROJECT_TITLE: Purchase of a Benchtop Flow Cytometer


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: WAGENAAR, JOOST B (contact)

PROGRAM_OFFICER_NAME: QASHU, FELICIA M

PROJECT_TERMS: Address;Architecture;big-data science;Biological Markers;cloud based;Collaborations;Communities;Computer software;cost;Custom;Data;data access;Data Analyses;data exchange;data integration;data management;Data Set;Diagnosis;Ecosystem;experience;Fostering;improved;Infrastructure;interoperability;Link;Medical;Modality;multimodal data;Neurosciences;next generation;open data;Organism;predictive modeling;Process;programs;Research Personnel;Security;Standardization;System;tool;Work

PROJECT_TITLE: Pennsieve: A scalable and sustainable platform for scientific data integration and analysis

STUDY_SECTION: DCMM

STUDY_SECTION_NAME: Data Coordination, Mapping, and Modeling[DCMM(50)]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Molecular principles of four RNA-mediated machineries including CRISPR-Cas enzymes from bacteria and snoRNPs from yeast will be studied towards construction and testing of innovative anti-cancer therapeutic, genome manipulation and virus detection tools.

PI_NAMEs: LI, HONG  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: anti-cancer therapeutic;Bacteria;Biological;Biological Process;Biology;Biophysics;Cell Physiology;chemical reaction;Chemicals;Chemistry;Clustered Regularly Interspaced Short Palindromic Repeats;Cryoelectron Microscopy;Diagnostic;DNA;Engineering;Enzymes;Epigenetic Process;Funding;Gene Expression Regulation;Genome;Goals;Guide RNA;Immunity;innovation;Laboratories;mammalian genome;Mediating;Methods;Methylation;Microbiology;Modification;Molecular;nucleic acid detection;Nucleic Acids;particle;Pathway interactions;Process;Proteins;Research;Ribonucleoproteins;Ribosomal RNA;risk mitigation;RNA;Scientist;Secure;Signal Transduction;single molecule;Small Nucleolar Ribonucleoproteins;structural biology;Testing;Therapeutic;tool;Translations;viral detection;virology;X-Ray Crystallography;yeast genetics;Yeasts

PROJECT_TITLE: Mechanisms and Applications of RNA-mediated Enzymes in Translation and Immunity

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: OVERALL: PROJECT NARRATIVE The OU Stephenson Cancer Center fulfills a unique need in Oklahoma and the region by conducting innovative and impactful research that seeks to translate novel discoveries into the clinical or community setting through a transdisciplinary team-based approach. The goal of these efforts is to decrease cancer incidence and improve outcomes for Oklahomans and all individuals, with a special emphasis on promoting cancer health equity among the state’s underserved minority populations.

PI_NAMEs: MANNEL, ROBERT S. (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Achievement;Address;Administrative Supplement;African American;American Indian Tribe;American Indians;anti-cancer research;Applications Grants;Black race;cancer care;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer health equity;cancer prevention;career;career development;Career Mobility;Catchment Area;Clinical;Clinical Trials;Colon Carcinoma;Communities;community setting;design;Development;distraction;Ecosystem;Educational workshop;Ensure;Environment;Evaluation;Financial Support;Fostering;Funding;Funding Agency;Goals;Grant;Growth;Health;Health Disparities Research;Health Technology;improved;improved outcome;Incidence;Individual;Infrastructure;innovation;Intervention;Investments;Leadership;Longitudinal Studies;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;member;Mentors;Mentorship;mHealth;Minority Groups;minority investigator;Mission;morphogens;mortality;multidisciplinary;NCI-Designated Cancer Center;novel;Occupations;Oklahoma;Oncology;organizational climate;Participant;Pathway interactions;patient oriented;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;pressure;Process;Productivity;Program Effectiveness;Program Sustainability;programs;Publications;recruit;Reporting;Research;Research Peer Review;Research Personnel;Role;Rural Population;satisfaction;Science;Seasons;Secure;Site;skills;social health determinants;success;Support System;Therapeutic;tobacco control;Training;Training Activity;training opportunity;Translating;Underrepresented Minority;underserved minority;United States National Institutes of Health;Universities;Update;Vision;Vulnerable Populations;Writing

PROJECT_TITLE: D.R.I.V.E: Catalyzing Oncology Research Excellence and Enhancing Grant Writing Proficiency through Expert Mentorship


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Machine Learning and Artificial Intelligence;Pancreatic Cancer;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE  This project is to develop and validate low-dose quantitative dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) of the pancreas under free-breathing conditions. This will be accomplished by cultivating a new technology, DCE MR Multitasking, which can quantify tissue kinetic and flow parameters even in moving organs. The resulting technology will offer clinicians and investigators a valuable tool to diagnose, monitor, and study pancreatic and other cancers.

PI_NAMEs: CHRISTODOULOU, ANTHONY G (contact);LI, DEBIAO

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Abdomen;Address;Arrhythmia;Blood Plasma Volume;Blood Vessels;Breathing;Cancer Etiology;cancer imaging;Cardiovascular Diseases;Cessation of life;contrast enhanced;Contrast Media;deep learning;design;Development;Diagnosis;Dimensions;Disease;Dose;Early Diagnosis;Electrocardiogram;Excision;Fibrosis;Gadolinium;healthy volunteer;Heart;heart imaging;heart motion;histological image;Histology;Image;Image Enhancement;image reconstruction;improved;Inflammation;Injections;Ischemia;Kinetics;learning network;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Measurement;Modeling;Monitor;Motion;Multicenter Studies;multitask;Nature;Necrosis;Neoadjuvant Therapy;Nervous System Disorder;network models;new technology;non-invasive imaging;novel;Odds Ratio;Operative Surgical Procedures;Organ;Pancreas;pancreas imaging;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;Parameter Estimation;Pathologic;Patients;Perfusion;pharmacokinetic model;prevent;Prior Therapy;Process;Property;quantitative imaging;reconstruction;Recovery;Reproducibility;Research Personnel;Resectable;Resected;respiratory;Risk Assessment;Safety;Series;Signal Transduction;Specimen;Staging;Techniques;Technology;temporal measurement;Three-Dimensional Imaging;Time;Tissues;tool;tumor;tumor microenvironment;Validation

PROJECT_TITLE: Fully Quantitative Low-Dose, Motion-Resolved Dynamic Contrast-Enhanced MRI in Pancreatic Adenocarcinoma

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

PHR: Narrative Through this supplemental funding award, the UCLA Jonsson Comprehensive Cancer Center Community Outreach and Engagement (JCCC COE) team will collaborate with community partners, the Mixteco Indigena Community Organizing Project (MICOP) and Antelope Valley Partners for Health (AVPH) to develop tailored multi-channel communication campaigns to promote cancer screening and tobacco control in predominately low-income Latinx communities in two high need regions served by the JCCC. Supplement activities are expected to reach over 78,500 residents and will include radio campaigns, social media campaigns, training of community health workers, and referral to cancer screening services. Receipt of this supplement will be instrumental in expanding our capacity to promote cancer screening and tobacco control in the high-need Latinx communities served by these organizations and to disseminate our messages and approaches more broadly.

PI_NAMEs: TEITELL, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Administrative Supplement;Advisory Committees;Affect;Age;aged;agricultural community;Antelopes;Area;Award;Awareness;Breast Cancer Detection;California;Cancer Center Support Grant;cancer education;cancer health disparity;Cervical Cancer Screening;Clinic;colorectal cancer screening;Communication;Communities;community collaboration;community engagement;Community Health Aides;community organizations;Community Outreach;community partners;community setting;Comprehensive Cancer Center;County;Dedications;empowerment;Evaluation;experience;Face;Funding;Funding Opportunities;General Population;Health;health care availability;Health Services;Immigrant;improved;Indigenous;Interview;Jonsson Comprehensive Cancer Center of University of California Los Angeles;Knowledge;Language;Latinx;Linguistics;Los Angeles;Low income;lung cancer screening;Media Campaign;member;Mission;Outcome;outreach;preference;Radio;Resources;screening;Screening for cancer;screening services;social media;Social Work;success;Surveys;tailored messaging;tobacco control;Training;Underserved Population;Work


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: CHARLES R. DREW UNIVERSITY OF MED & SCI

PHR: Project Narrative  The goal of this IPERT renewal application, submitted by California State University, Long Beach (CSULB) Center for Health Equity Research (CHER), is to provide enhanced educational and mentored activities to increase the readiness of diverse early career faculty at minority serving institutions (MSIs) to conduct community-engaged biomedical research designed to promote health equity, including research with basic, clinical, behavioral, and translational outcomes. CHER aims to increase the number of scientists from MSIs represented among National Institutes of Health (NIH)-funded investigators because scientists from MSIs bring unique perspectives and experiences, which are required to successfully diversify the workforce and enhance health equity biomedical research, particularly in the areas of reaching underrepresented minority communities, building trust, healing historical injustices, and enhancing participation in research.

PI_NAMEs: D'ANNA, LAURA HOYT (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Achievement;Applications Grants;Area;Behavioral;Biomedical Research;biomedical scientist;California;Clinical;Communities;Community Developments;community engagement;comparison group;Data Collection;Databases;Development;early experience;early-career faculty;Education;education research;effectiveness evaluation;ethnic minority population;Evaluation;evidence base;experience;Faculty;faculty mentor;Female;Funding;Goals;Grant;healing;health equity;health equity promotion;Health equity research;Individual;Institution;interest;Manuscripts;member;Mentors;method development;Methods;Minority;minority communities;Minority Recruitment;minority scientist;Minority-Serving Institution;Modeling;National Institute of General Medical Sciences;online repository;Outcome;Outcome Assessment;Participant;Peer Review;Persons;Procedures;Productivity;Publications;racial minority population;Readiness;Research;Research Design;Research Institute;Research Personnel;Research Training;Resource Development;Sister;skill acquisition;skills;statistics;success;Teacher Professional Development;tenure track;Testing;theories;Training;Training and Education;Trust;Underrepresented Minority;United States National Institutes of Health;Universities;virtual;webinar;wiki;Writing

PROJECT_TITLE: Center for Health Equity Research Institute II: Community-engaged biomedical research training and mentored experiences for early career faculty


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Pediatric;Pediatric - AIDS;Rare Diseases;Tuberculosis

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: Mycobacterium tuberculosis (Mtb) infects one-third of the world’s population and causes almost 1.3 million deaths per year, including 100, 000 children. Approximately 90% of infected persons have latent tuberculosis infection (LTBI), have protective immunity and remain well, but 10% develop primary tuberculosis (TB) soon after infection or reactivation TB many years later. TB is the leading cause of death in HIV-infected persons and more than half a million coinfected people die annually. Children are more susceptible to TB infection, due to an immature immune system. HIV infection in children markedly increases susceptibility to TB. To develop adequate prophylaxis or therapy, it is important to understand immune responses to Mtb. Identification of HIV+ children with LTBI who are at greatly increased risk for development of TB would allow treating only high-risk children, facilitating completion of therapy for LTBI and preventing future development of TB. To identify these children, it is important to pinpoint the nature of the defective immune responses that permit development of active TB in HIV+LTBI+ pediatric patients. This proposal will identify a novel memory-like NK cell subpopulation mediated mechanisms that regulate immune responses and pinpoint the nature of the defective responses that permit development of active TB in HIV-LTBI+ and HIV+LTBI+ children. These studies will lay the groundwork for strategies to develop novel anti-tuberculosis vaccines that stimulate strong NK cell mediated immunity in HIV+ and HIV- children with LTBI, and reduce development of TB.

PI_NAMEs: VANKAYALAPATI, RAMAKRISHNA  (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: adaptive immune response;Adult;Age;Antitubercular Agents;Blood specimen;Cause of Death;CD8-Positive T-Lymphocytes;cell mediated immune response;Cells;Cellular Immunity;Cessation of life;chemokine;Child;cohort;cytokine;Defect;Development;Family;FOXP3 gene;Future;Genetic Polymorphism;Growth;Haplotypes;high risk;Highly Active Antiretroviral Therapy;HIV;HIV Infections;HIV/TB;Household;Human;IL2RA gene;Immune;Immune response;Immune system;Immunity;Immunoglobulins;India;Individual;individual response;Infection;Innate Immune Response;interleukin-21;interleukin-21 receptor;Investments;Killer Cells;Macrophage;Measures;Mediating;Memory;monocyte;Mus;Mycobacterium tuberculosis;Natural Killer Cells;Nature;novel;Patients;pediatric patients;Persons;Phenotype;Play;Population;Predisposition;prevent;Production;progression risk;Prophylactic treatment;Publishing;receptor;Reporting;Research;Research Personnel;Resistance;response;Response Latencies;Risk;Role;Sampling;Series;Site;T cell response;Time;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;Vaccines

PROJECT_TITLE: Innate immune response of LTBI+HIV+ children

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]