NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Rehabilitation;Prevention;Rehabilitation;Stroke

ORG_CITY: East Hanover

ORG_NAME: KESSLER FOUNDATION, INC.

PHR: Project Narrative The proposed investigation will be the first comprehensive study to evaluate a progressive and adaptive assist-as-needed intensive exoskeleton robotic (ER) intervention (30 hours of training) in the acute phase post stroke and its effect on functional recovery, neuromuscular adaptations, and neuroplasticity. This research will have a significant impact on possibly accelerating recovery following stroke by examining the underpinnings of plasticity and functional adaptation to injury and ER interventions. A multidisciplinary research team and cutting-edge technology will be employed to achieve this research goal.

PI_NAMEs: NOLAN, KAREN J. (contact);SALEH, SOHA

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Acceleration;Acute;acute stroke;Adopted;Age;Agreement;Area;Attention;Bilateral;Brain;Central Nervous System;central nervous system injury;chronic stroke;Computer software;Data;dosage;Dose;Early Intervention;Economics;Educational Intervention;effective therapy;Equilibrium;Exhibits;exoskeleton;Failure;functional adaptation;functional improvement;Functional Magnetic Resonance Imaging;Gait;gait rehabilitation;Gender;Goals;graph theory;Hour;Image;improved;Individual;Injury;injury recovery;innovative technologies;Interdisciplinary Study;Intervention;Investigation;Lead;Long term disability;Magnetic Resonance Imaging;Measures;Medical;Modality;Modeling;Motor Activity;Motor Cortex;Motor Evoked Potentials;motor function recovery;Movement;Muscle;neuroadaptation;neuromuscular;Neuronal Plasticity;neurophysiology;Participant;Pathway interactions;Patient Education;Patients;Pattern;Phase;Physical activity;physical therapist;Physical therapy;post stroke;Prognosis;prognostic model;programs;Randomized;Recovery;Recovery of Function;recruit;Rehabilitation therapy;Research;Research Personnel;Residual state;Resistance;response;response to injury;Rest;Robot;robot assistance;robot exoskeleton;Robotics;Signal Transduction;standard of care;Stroke;stroke patient;stroke rehabilitation;stroke survivor;Survivors;System;Techniques;Technology;technology intervention;Therapeutic Effect;Time;Training;Training Programs;Transcranial magnetic stimulation;transmission process;United States;United States National Institutes of Health;Walking;wearable device;wireless

PROJECT_TITLE: Functional and neurophysiological effects of a progressive robot assisted gait intervention early post stroke

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Stargardt disease is an inherited form of macular degeneration caused by mutations in the ABCA4 gene. There are no therapies for Stargardt disease. We propose to design a new small-molecule polypharmacological agent for treating this blinding condition.

PI_NAMEs: CIOFFI, CHRISTOPHER L.;MOISEYEV, GENNADIY ;PETRUKHIN, KONSTANTIN  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 11-cis-Retinol;Ablation;absorption;adduct;Adverse effects;Adverse event;Aldehydes;Alleles;Amines;Amino Acid Substitution;analog;antagonist;Applications Grants;Biochemical;Biochemical Pathway;Biological Availability;Biological Markers;Blood;Characteristics;Chronic;Clinical;clinical efficacy;Clinical Trials;cytotoxic;Defect;design;Disease;Dose;Drug Kinetics;Drug Targeting;Enzymes;Equilibrium;Esters;Evaluation;Excretory function;experimental study;Frequencies;Future;General Population;Genes;Genetic;Genetic Models;Goals;Heterozygote;Human;improved;In Vitro;in vivo;in vivo evaluation;Inherited;inhibitor;Lipofuscin;Macular degeneration;macular dystrophy;Metabolism;mouse genetics;mouse model;Mouse Strains;Mus;mutant;Mutation;Nonexudative age-related macular degeneration;novel;Oral;Pathologic;Patients;Pattern;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;pharmacologic;Phase;Photoreceptors;pre-clinical;preclinical efficacy;Prevalence;Production;Property;Reaction;response;Retina;retinal toxicity;Retinaldehyde;Retinoids;Rod;RPE65 protein;Safety;Schiff Bases;Series;Serum;Severities;Signal Transduction;small molecule;Specificity;Stargardt's disease;Structure of retinal pigment epithelium;Testing;Therapeutic;Treatment Efficacy;treatment strategy;Vision;Visual;visual cycle

PROJECT_TITLE: Polypharmacological approach to treatment of Stargardt disease

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Latinos living in the 50 United States (US) have about 1.5 times the risk of Alzheimer’s disease as non-Latino whites with Puerto Ricans representing the Latino background with the highest prevalence of mild cognitive impairment and cardiovascular disease risk factors, both long associated with Alzheimer’s disease and related dementias (ADRD) risk. The overall research and training goals of this K01 center around investigating protective factors to promote healthy cognitive and brain aging in middle-aged and older Latinos (ages 45+) and expand work currently being conducted in the continental US to the US territory of Puerto Rico. Findings may inform the development of culturally-targeted interventions to support healthy cognitive and brain aging in Latinos, the largest racial/ethnic minority group in the US, with a particular focus on Puerto Ricans.

PI_NAMEs: ESTRELLA, MAYRA LORELL (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Adult;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Ancillary Study;Area;Body Composition;Body fat;Brain;brain health;brain magnetic resonance imaging;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;Central American;Chronic Disease;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive reserve;cohort;Community Health;Cuban;Data;Death Rate;dementia risk;depressive symptoms;Development;Disparity;Disparity population;Dominican;Education;Epidemic;Epidemiology;epidemiology study;ethnic minority;ethnic minority population;Ethnic Origin;executive function;Exhibits;experience;Fatty acid glycerol esters;follow-up;Functional disorder;Funding;Goals;Health;health equity;Health Promotion;Health Sciences;healthy aging;High Prevalence;Hispanic Community Health Study/Study of Latinos;Household;human old age (65+);indexing;insight;Intervention;Investigation;Island;Knowledge;Latino;Latino Population;Magnetic Resonance Imaging;Maintenance;Measures;Memory;Mental Health;Mexican;middle age;mild cognitive impairment;National Heart, Lung, and Blood Institute;Neurocognitive;neuroimaging;Observational Study;Occupations;Participant;Persons;Population;Positioning Attribute;post-doctoral training;programs;protective factors;Protocols documentation;Psychosocial Assessment and Care;Puerto Rican;Puerto Rico;racial minority;racial minority population;Research;Research Personnel;resilience;Risk Factors;Schedule;skills;socioeconomic disadvantage;South American;Structure;Study of Latinos;Testing;theories;Training;trend;Underrepresented Populations;United States;Visit;Work

PROJECT_TITLE: Protective Factors of Cognitive Aging among Latinos in the 50 States and Puerto Rico

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung

ORG_CITY: GAINESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Loss of lung tolerance causes chronic lung diseases, including asthma and COPD. This study aims to uncover the mechanism of lung tolerance and further develop therapeutics for chronic lung diseases. The knowledge obtained will improve healthcare for lung disease patients.

PI_NAMEs: JIN, LEI  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Adoptive Cell Transfers;Affect;Allergic Disease;Alveolar;alveolar type II cell;Amino Acids;arginase;Asthma;autocrine;Caring;Cause of Death;Cells;Chemicals;Chimeric Proteins;chronic inflammatory lung disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;conditional knockout;Cues;Dendritic Cells;Development;Disease Progression;effective therapy;efficacy evaluation;Enzymes;Epithelial Cells;Epithelium;Extrinsic asthma;Goals;Healthcare;Human;IFNAR1 gene;Immune system;Immune Tolerance;immunogenic;Impairment;improved;in vivo;Infection;Inflammation;inflammatory lung disease;Inhalation;inhibitor;innovation;Interferon alpha;Knockout Mice;Knowledge;Lung;Lung Diseases;Lung immune response;Mediating;Medicine;Metabolic;MHC Class II Genes;microbiota;Molecular;Monoclonal Antibodies;mouse model;Mucous Membrane;Mus;neutrophil;Organ;paracrine;Pathogenicity;Patients;Persons;pneumocyte;Population;prevent;Production;programs;Proto-Oncogene Proteins c-akt;Pulmonary Inflammation;Pyroglyphidae;Receptors, Tumor Necrosis Factor, Type II;Regimen;Regulatory T-Lymphocyte;relapse patients;Reporting;Repression;Research;response;Role;Signal Transduction;Source;STAT1 gene;STAT3 gene;Steroid Resistance;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutic target;TNFRSF1B gene;Transforming Growth Factor beta;translational potential;Tryptophan 2,3 Dioxygenase

PROJECT_TITLE: Lung IDO-1+ TNFR2+ cDC2 subset in control of lung mucosal tolerance: Mechanism and Application

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PUBLIC HEALTH RELEVANCE Atrial fibrillation (AF) is the most common heart rhythm disorder and is a major cause of stroke. The incidence of AF increases with age, making it an ‘epidemic’ in an aging population. Unfortunately, current treatments for AF – especially chronic or persistent AF - have low efficacy. We propose to study the role of three major molecular mechanisms – called autonomic nervous system remodeling, NLRP3 induced fibrosis and derailed proteostasis – in the genesis of persistent AF. The proposed approach will use novel biological agents (genes) to target these mechanisms. These genes, if successful in preventing persistent AF, will have immense therapeutic potential in the management of patients with this arrhythmia.

PI_NAMEs: ARORA, RISHI  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Ablation;Affect;Age;age-related disease;aging population;American;Animal Model;Arrhythmia;Atrial Fibrillation;Autonomic nervous system;Biological Products;Chronic;Clinical;Coupling;Development;Disease;Electroporation;Epidemic;Fibrosis;Gene Delivery;gene therapy;gene-targeted therapy;Genes;Goals;HDAC6 gene;Heart Atrium;heart rhythm;Incidence;Inflammasome;insight;Ion Channel;Mediating;Microtubules;Molecular;Myopathy;Nerve;novel;oxidative damage;Patients;pharmacologic;Phase;prevent;Proteins;proteostasis;public health relevance;Research;Role;Signal Transduction;Stroke;success;Therapeutic;Universities;Venous;Work

PROJECT_TITLE: New and Disruptive Therapeutic Approaches to Target Fundamental Molecular Mechanisms Underlying Atrial Fibrillation


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative Hypoxia ischemia encephalopathy remains a leading cause of death and disability in newborns. This proposal aims to augment efficacy of hypothermia, the standard of clinical care in severe cases, through modulation of mitochondrial function, specifically Complex I.

PI_NAMEs: POLSTER, BRIAN M;WADDELL, JAYLYN WADDELL (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: 3-nitrotyrosine;Acute;Aftercare;Animals;Apoptosis;Apoptotic;Behavioral Assay;behavioral outcome;Birth;blood-brain barrier permeabilization;Brain;Brain Hypoxia-Ischemia;brain tissue;Cause of Death;Cell Death;Cells;Cessation of life;Chronic;Clinical;clinical care;Cognitive;cohort;Complex;cytochrome c;cytokine;Data;Development;Diagnosis;disability;Dose;Electron Transport;Energy Metabolism;Epilepsy;Event;Exhibits;Exposure to;Failure;Female;Functional disorder;functional outcomes;Genetic;Genetic Models;genetic signature;glial activation;Goals;Hippocampus;Histopathology;HMGB1 gene;Hour;Hyperoxia;Hypoxic-Ischemic Brain Injury;Immune;Immunohistochemistry;improved;In Vitro;in vivo;in vivo evaluation;Induction of Apoptosis;Infant;Infant Care;Inflammatory;Inflammatory Response;inhibitor;Injury;Intervention;Knock-in Mouse;Label;Lesion;male;Measures;Mediating;Methods;Microglia;Mitochondria;Modeling;Morbidity - disease rate;Motor;mouse model;Multiple Trauma;Mus;Myocardial Ischemia;natural hypothermia;neonatal hypoxic-ischemic brain injury;neurodevelopment;neuroinflammation;Neurological outcome;Neurons;neuroprotection;Newborn Infant;novel;Outcome;Outcome Measure;oxidation;Oxidative Stress;Pathway interactions;Pharmaceutical Preparations;Phase;postnatal;pre-clinical;prevent;Production;Publishing;Rattus;Reactive Oxygen Species;Recovery;Reperfusion Injury;Reperfusion Therapy;Residual state;Respiration;response;Rice;Rodent Model;Role;Secondary to;Series;sex;sexual dimorphism;Signal Transduction;Stains;Succinates;Testing;Therapeutic;Tissues;TLR4 gene;translational approach;Work

PROJECT_TITLE: Targeting mitochondrial Complex I in neonatal hypoxia-ischemia

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: BOSTON

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: NARRATIVE Dilated cardiomyopathy (DCM), a major cause of heart failure, enlarges the chambers and reduces the function of the heart. Damaging DNA variants are an important cause of DCM that are identified in 20-40% of patients, but the cause(s) of DCM in many patients remains unexplained. We propose to use new molecular technologies to study DNA sequences and single cells of unexplained DCM patient heart tissue hoping to identify new causes or contributors to DCM that will lead to improved diagnosis and treatments for these patients.

PI_NAMEs: CHEN, CHRISTOPHER S;SEIDMAN, CHRISTINE E;SEIDMAN, JONATHAN G (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Alcohol abuse;Architecture;Biological Models;Biology;Blood;cancer therapy;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular system;Cells;Cellular Assay;Cessation of life;Code;Communication;Communities;connectin;Cytoskeleton;Data;Diagnosis;Dilatation - action;Dilated Cardiomyopathy;Disease;DNA;DNA Damage;DNA Sequence;Engineering;Etiology;familial dilated cardiomyopathy;Fibrosis;FLNC gene;Funding;gene discovery;Gene Dosage;Gene Expression;Gene Expression Profile;General Population;Generations;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;Genetic Transcription;genetic variant;Genome;genome sequencing;Genotype;Germ-Line Mutation;Goals;Grant;Heart;Heart failure;heart function;Heart Transplantation;Heavy Drinking;high risk;Homeostasis;Human;human tissue;improved;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inflammation;insight;Knowledge;Left;Mitochondria;Molecular;mouse model;Myocardial dysfunction;Nuclear;Nuclear RNA;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Performance;Phenotype;Population;Precision therapeutics;Pregnancy;premature;prevent;Primary idiopathic dilated cardiomyopathy;Proteins;Risk;Role;Signal Transduction;single nucleus RNA-sequencing;Somatic Mutation;Technology;Therapeutic;Tissues;transcriptome sequencing;transmission process;Untranslated RNA;Variant;variant of unknown significance;Ventricular;virulence gene;whole genome

PROJECT_TITLE: Defining Genetic Architecture and Pathways of DCM

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS

ORG_CITY: BUENOS AIRES

ORG_COUNTRY: ARGENTINA

ORG_FIPS: AR

ORG_NAME: FACULTAD LATINOAMERICANA DE CIENCIAS SOCIALES

PHR: Project Narrative This program educates researchers and members of research ethics committees from Latin American countries and improves their expertise in research ethics, thereby increasing ethical capabilities in the conduct and review of research. It also provides continuing education in research ethics for former trainees to ensure ongoing sustainability of research ethics in the region.

PI_NAMEs: LUNA, FLORENCIA  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Active Learning;Address;Advisory Committees;Americas;Area;Argentina;Attention;Awareness;Career Choice;Collaborations;college;community advisory board;Continuing Education;Country;Critical Thinking;Education;Educational Activities;Educational Status;Ensure;Ethical Issues;Ethicists;Ethics;experience;Health;improved;Individual;innovation;Institution;International;Journals;Latin American;learning strategy;Master of Science;Medicine;meetings;member;Mentors;Persons;post-doctoral training;programs;Publishing;Reading;Research;Research Ethics;Research Ethics Committees;Research Personnel;Resources;responsible research conduct;Scientist;skills;Social Sciences;System;systems research;Time;Training;Training Programs;Work;Workload;Writing

PROJECT_TITLE: Training Program in Research Ethics in the Americas


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Gene Therapy;Genetics;Human Genome;Nanotechnology;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: The blood-brain barrier is a specialized feature of brain capillaries that protects brain tissue from harmful substances that may be present in blood. Dysfunction of this barrier contributes to many brain pathologies; therefore, the development of minimally-invasive approaches capable of modulating genes in the blood-brain barrier would represent a powerful technology. To this end, in this proposal, we will develop a therapeutic approach that uses MR image-guidance and focused ultrasound energy to deliver gene-therapy agents that modulate the genome of the blood-brain barrier with high spatial precision.

PI_NAMEs: PRICE, RICHARD J. (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: ABCB1 gene;Acoustics;Amino Acids;astrogliosis;Ataxia;Back;Binding;Blood;Blood - brain barrier anatomy;Blood Circulation;blood-brain barrier disruption;Brain;brain metabolism;Brain Pathology;brain tissue;cell type;Cells;Central Nervous System;Central Nervous System Diseases;cerebral capillary;Cerebral endothelium;cerebrovascular;CMV promoter;Coupled;CRISPR/Cas technology;Data;Development;Disease;DNA Sequence Alteration;Drug Delivery Systems;Drug Efflux;Dysarthria;Endonuclease I;Endothelial Cells;Endothelium;Engineering;Epilepsy;Feedback;fluorodeoxyglucose;Focused Ultrasound;Formulation;Functional disorder;Gene Deletion;Gene Delivery;Gene Therapy Agent;Genes;genetic manipulation;Genome;genome editing;Genomics;Gliosis;Glucose;Guide RNA;Health;image guided;immune cell infiltrate;Immunofluorescence Immunologic;Immunohistochemistry;improved;Inflammation;Intellectual functioning disability;Magnetic Resonance Imaging;Microbubbles;Microcephaly;Microcirculation;minimally invasive;molecular modeling;Molecular Target;Monitor;nanoparticle;nanopolymer;neural;Neurosciences Research;Nutrient;Pathology;Plasmids;Positron-Emission Tomography;pre-clinical;pressure;promoter;Publications;Recurrence;red fluorescent protein;Role;Safety;single-cell RNA sequencing;SLC2A1 gene;Sorting;spasticity;Stains;Sterility;Symptoms;Syndrome;System;targeted treatment;Technology;technology platform;Testing;Therapeutic;Tight Junctions;tissue preparation;Tissues;Transfection;transgene expression;Treatment Efficacy;Ultrasonic Therapy;ultrasound;United States National Academy of Sciences;Verapamil;Xenobiotics

PROJECT_TITLE: Genome Editing the Blood-Brain Barrier with Sonoselective Focused Ultrasound

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative: Persistent smell loss after viral infections is common, especially in light of the COVID-19 pandemic, with significant impacts on quality of life. This research will study the role of the innate immune system and how local inflammation might cause hinder olfactory cell regeneration and cause persistent smell loss. A better understanding of these mechanisms has the potential to guide development of novel therapies to treat post- viral smell loss.

PI_NAMEs: YAN, CAROL H (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: 2019-nCoV;Address;Anosmia;antagonist;Anti-viral Response;Area;Basal Cell;Behavior;Body System;cell behavior;Cell Differentiation process;cell regeneration;Cells;Chronic;Clinical;comparison control;COVID-19;COVID-19 pandemic;COVID-19 patient;cytokine;Data;Development;Environment;epithelium regeneration;Functional disorder;Future;Gene Expression;Genes;genetic manipulation;Human;human model;Immune response;Impairment;In Vitro;in vivo;in vivo evaluation;Individual;Infection;Inflammation;Inflammatory;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;influenzavirus;inhibitor;Injury;Innate Immune Response;Innate Immune System;interest;Interferon alpha;Interferon Type I;Interferon Type II;Interferons;Interleukin-6;Knowledge;Light;Link;Maps;Measures;Mediating;Molecular;mouse model;Mucous body substance;Mucous Membrane;Mus;Natural regeneration;neurogenesis;notch protein;Notch Signaling Pathway;novel therapeutics;Olfactory dysfunction;Olfactory Epithelial Cell;Olfactory Epithelium;Olfactory Mucosa;olfactory neurogenesis;Olfactory Pathways;olfactory sensory neurons;Outcome;Pathway interactions;Peripheral;Population;Proliferating;Quality of life;Research;response;Role;SARS-CoV-2 infection;Signal Induction;Signal Pathway;Signal Transduction;Signaling Protein;Smell Perception;stem cell differentiation;stem cell population;stem cell proliferation;stem cells;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Tissues;transcriptome sequencing;transcriptomic profiling;Translating;Translations;Treatment Efficacy;Undifferentiated;Up-Regulation;Viral;Virus;Virus Diseases;WNT Signaling Pathway

PROJECT_TITLE: Elucidating Olfactory Epithelial Anti-Viral Responses in Persistent Post-Viral Olfactory Dysfunction

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: ES

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Electronic Nicotine Delivery Systems;Health Effects of Indoor Air Pollution;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Tobacco;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative The consequence of maternal vaping during pregnancy during long-term cerebrovascular health in offspring are not known. This project combines aerosol characterization to structural and functional changes in cerebral blood vessels in adolescent and adult offspring born with maternal vaping exposure that occur at different time points during pregnancy.

PI_NAMEs: MILLS, AMBER  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Adolescence;Adolescent;adolescent offspring;Adult;Adult Children;Aerosols;aged;Alzheimer's Disease;Arteries;Blood Vessels;Cardiovascular system;cerebral microbleeds;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular health;cerebrovascular reactivity;Cerebrovascular system;Chronic;Clinical;Data;Development;Disease;Electronic cigarette;electronic cigarette use;Endothelium;Environment;expectation;Exposure to;Fetal Development;First Pregnancy Trimester;Functional disorder;Goals;Guidelines;Health;Health Personnel;Hypertension;Impairment;in utero;Individual;Inhalation Exposure;Knowledge;Life;Literature;Long-Term Effects;Marketing;Maternal Exposure;maternal vaping;Measurable;Neurocognitive Deficit;Nicotine;offspring;Outcome;Pattern;pre-clinical;preclinical study;Pregnancy;Pregnant Women;prenatal exposure;Public Policy;Publishing;Recommendation;Recording of previous events;Regulation;Reporting;Resistance;response;Risk;Risk Factors;Rodent;Rodent Model;Second Pregnancy Trimester;Secondary to;Smoking;smoking during pregnancy;stem;Structure;Testing;Third Pregnancy Trimester;Time;Toxic effect;Toxicology;vaping;vascular abnormality;Vascular Diseases;vascular risk factor

PROJECT_TITLE: Consequences of Maternal Vaping on Cerebrovascular Health in Offspring

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SAN JUAN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: NARRATIVE Huntington’s disease (HD) is a progressive neurodegenerative disease which manifests between 35-45 years of age caused by a mutation consisting of an expansion of a CAG repeat in the huntingtin gene. The length of the CAG expansion correlates with age of onset, however, individuals with equal repeat length develop symptoms decades later than expected, suggesting that other factors in addition to the gene expansion can modify the age of disease onset. Our proposed work will address this question and is of direct significance to the development of new drugs to delay HD age of onset and progression.

PI_NAMEs: AYALA-PENA, SYLVETTE  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Activities of Daily Living;Adolescent;Age;age effect;Age of Onset;Age Years;Autopsy;base;Base Excision Repairs;Bioenergetics;Brain;CAG repeat;caudate nucleus;Cell Line;Cells;Cerebral cortex;Clinical;Confocal Microscopy;Corpus striatum structure;Data;Development;Disease;Disease Progression;DNA;DNA Damage;DNA lesion;DNA Repair;DNA-(apurinic or apyrimidinic site) lyase;drug discovery;endonuclease;Event;Exhibits;extracellular;Failure;Fibroblasts;Functional disorder;Future;Genes;Genetic;Genus Hippocampus;Health;Human;Human Cell Line;Huntington Disease;Huntington gene;Impairment;Individual;Inherited;Intervention;Knowledge;Label;Late-Onset Huntington Disease;Length;Leukocytes;Life;Maintenance;Measurement;Measures;Mediating;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modification;Motor;mouse model;Mus;mutant;Mutation;mutation carrier;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuron apoptosis;neuron loss;Neuronal Dysfunction;novel therapeutics;Oligonucleotides;Onset of illness;oxidative damage;oxidative DNA damage;Pathogenicity;Patients;peripheral blood;pharmacologic;prevent;Process;Publications;putamen;Regulation;repair function;repaired;Research;Role;Severity of illness;Site;Skin;Source;Symptoms;Testing;therapy development;Tissues;United States National Institutes of Health;Work

PROJECT_TITLE: APE1 and Somatic Expansion in Huntington's Disease


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: Los Angeles

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE There is a growing need to evaluate orthopedic metallic implants in patients, including hip replacements and spinal fixations. While magnetic resonance imaging (MRI) is commonly used, the presence of metal causes substantial distortion in the images, preventing our ability to diagnose complications close to the implants. This project will develop improved MRI technology to take pictures of the soft tissues within a few millimeters of the implants, which doctors cannot see with any current technology, and where most complications occur.

PI_NAMEs: HARGREAVES, BRIAN ANDREW;NAYAK, KRISHNA S (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acceleration;Anatomy;Area;Artificial Intelligence;Body System;bone;Calibration;Chromium;Cobalt;cohort;Compensation;Complication;Computer software;Decision Making;Degenerative polyarthritis;denoising;design;Devices;Diagnosis;Diagnostic;Evaluation;Excision;Failure;Fatty acid glycerol esters;Fracture;Goals;Hip region structure;hip replacement arthroplasty;Image;imaging approach;imaging modality;Imaging Techniques;Implant;improved;innovation;intervertebral disk degeneration;knee replacement arthroplasty;magnetic field;Magnetic Resonance Imaging;metallicity;Metals;millimeter;Modeling;Morphologic artifacts;Nerve;new technology;Noise;non-invasive imaging;novel;Operative Surgical Procedures;Orthopedics;Patient Care;Patients;Penetration;Performance;Physiologic pulse;Predisposition;prevent;Property;Protocols documentation;radio frequency;radiologist;Reader;reconstruction;Replacement Arthroplasty;Resolution;response;sample fixation;Shapes;Signal Transduction;Slice;soft tissue;spectrograph;Spinal;Stainless Steel;Standardization;stem;Structure;Surface;Surgeon;Synovitis;System;Techniques;Technology;Time;Tissue imaging;Tissues;Titanium;tool;Total Hip Replacement;transmission process;Trauma;Variant;Vertebral column;Water;X-Ray Computed Tomography

PROJECT_TITLE: Improved Diagnostic MRI around Metallic Implants

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Health Services;Networking and Information Technology R&D (NITRD);Palliative Care;Patient Safety;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative  With nearly 17 million cancer survivors living in the United States and 1.7 million new cancer diagnoses each year, effective delivery of supportive care to reduce symptom burden and promote quality of life in cancer patients is critical. There is strong evidence demonstrating the benefits of supportive care at all phases of cancer care, but unfortunately, many barriers exist to integration into routine cancer care, leaving many patients without adequate support for common physical and psychological symptoms. This project will develop and pilot test a novel tool within the electronic health record system to facilitate systematic symptom assessment and the tailored delivery of supportive care in a real-world multidisciplinary oncology setting.

PI_NAMEs: BRAUER, EDEN R. (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Acute;Address;Adoption;Algorithms;Ambulatory Care Facilities;Assessment tool;Attention;Behavior;cancer care;cancer diagnosis;Cancer Patient;Cancer Survivor;cancer therapy;care delivery;Caring;Chronic;Clinic;Clinical;clinical implementation;Clinical Informatics;clinical practice;clinically actionable;Collection;Communication;Complex;Continuity of Patient Care;cost effectiveness;Data;design;Detection;Development;Diagnosis;Disease;dissemination trial;Documentation;Early identification;effectiveness validation;eHealth;Electronic Health Record;electronic health record system;Electronics;Elements;Eligibility Determination;evidence base;experience;Face;Fatigue;Future;Goals;Guidelines;Head and Neck Cancer;head and neck cancer patient;Health;Healthcare Systems;implementation barriers;implementation science;implementation trial;Infrastructure;Institution;Intervention;K-Series Research Career Programs;Link;Malignant Neoplasms;Managed Care;Measurable;Mental Depression;Mentorship;Methods;Mission;Morbidity - disease rate;mortality;multidisciplinary;National Cancer Institute;novel;novel strategies;Oncology;Outcome Measure;outpatient programs;Pain;Pathway interactions;Patient Care;Patient Outcomes Assessments;patient-clinician communication;Patient-Focused Outcomes;Patients;Phase;physical symptom;pilot test;point of care;Population;pragmatic randomized trial;prevent;Process;programs;Protocols documentation;Provider;psychological symptom;Quality of life;Recommendation;reduce symptoms;Reporting;Research;Resources;response;Structure;Supportive care;Symptom Burden;symptom management;symptomatic improvement;Symptoms;System;Time;time use;tool;Training;United States;user centered design

PROJECT_TITLE: Harnessing the EHR for the Delivery of Supportive Care in an Oncology Setting

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: CAMBRIDGE

ORG_NAME: NOVOBIOTIC PHARMACEUTICALS, LLC

PHR: NARRATIVE Pneumonia is one of the most common infectious diseases and remains a significant cause of morbidity and mortality due to resistance to current antibiotics (CDC, 2019). The focus of this project is to advance our newly discovered antibiotic teixobactin to treat drug resistant pneumonia.

PI_NAMEs: HUGHES, DALLAS  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acute;Aerosols;Agreement;Ambulatory Care;Animal Model;Animals;Antibiotics;Bacillus anthracis;Bacterial Pneumonia;bactericide;Chemicals;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Protocols;Clinical Trials;co-infection;Code;Communicable Diseases;Communities;COVID-19;Development Plans;DNA;Dose;Drug Compounding;drug isolation;Drug resistance;Epithelium;Fermentation;Future;Goals;Gram-Positive Bacteria;Haemophilus influenzae;Hospitals;Human;improved;In Vitro;in vitro testing;in vivo;Infection;Infectious Skin Diseases;Inhalation;Intramuscular;Intravenous;intravenous administration;Investigational Drugs;Investigational New Drug Application;Lipid III;Liquid substance;Lung infections;Macrolide-resistance;manufacture;manufacturing cost;Maximum Tolerated Dose;methicillin resistant Staphylococcus aureus;microbial;Modeling;Moraxella catarrhalis;Morbidity - disease rate;mortality;mouse model;muramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenol;Mus;mutant;Mycobacterium tuberculosis;Nebulizer;Pamphlets;pathogen;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacology;Plasma;Pneumonia;pneumonia model;pre-Investigational New Drug meeting;preclinical development;predictive modeling;Predisposition;Production;Property;Rattus;Reporting;Research;Research Personnel;Resistance;resistance frequency;Resistance profile;Resistant Streptococcus pneumoniae;respiratory;respiratory pathogen;Respiratory Tract Infections;Route;Safety;Sepsis;side effect;Skin;Staphylococcus aureus;Streptococcus pneumoniae;Structure;Teichoic Acids;Test Result;Testing;Therapeutic;Thigh structure;Toxicology;Ventilator

PROJECT_TITLE: Developing Teixobactin for Respiratory Infections


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: EVANSTON

ORG_NAME: ENDEAVOR HEALTH CLINICAL OPERATIONS

PHR: NARRATIVE We will systematically identify neuropsychiatric disease risk variants that affect chromatin openness and gene expression in both baseline and activated human neurons, providing novel mechanistic insights on activity- dependent regulation of neuropsychiatric disorders. The identified regulatory variants in baseline and activated neurons will be a rich resource for deciphering disease causal mechanisms of brain disorders, facilitating the clinical translation of genetic findings into effective treatment.

PI_NAMEs: DUAN, JUBAO  (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Affect;Alleles;ATAC-seq;base editing;Binding;Binding Sites;Biological;Biological Assay;Biology;Brain Diseases;causal variant;cell type;Cells;Cellular Assay;ChIP-seq;Chromatin;Chromosome Mapping;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;cohort;CRISPR/Cas technology;Data;Data Set;Dendrites;Disease;DNA;effective therapy;Exhibits;Funding;Gene Expression;Genes;genetic variant;Genetic Variation;genome wide association study;Human;human induced pluripotent stem cells;improved;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;insight;Joints;Linkage Disequilibrium;Maps;Mediating;Mediation;Membrane;Modeling;Mus;neural;Neurons;neuropsychiatric disorder;neuropsychiatry;novel;Phenotype;Probability;Productivity;Quantitative Trait Loci;Regulation;Resolution;Resources;response;Rest;Risk;risk variant;Schizophrenia;schizophrenia risk;single cell ATAC-seq;single-cell RNA sequencing;stem cell model;Stimulus;Testing;transcription factor;translational genetics;Translations;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Systematic Functional Interpretation of Regulatory Variants in Neuropsychiatric Disorders

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative

ORG_DEPT: NEUROLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Older adults, a wealthy segment of the population, are known to exhibit compromised financial decision making especially in the context of age-related diseases such as Alzheimer's Disease. As the landscape of financial decision making has changed dramatically with rapid technological advances, there is a growing gap between the skills necessary for everyday financial decision making and the way it in which it is assessed clinically. Given the precipitous, ongoing and projected increase in the number of older adults and their use of technology, it is imperative to develop financial decision making measures that approximate real world functioning in the current technological culture that can inform clinical determination of financial decision making abilities, and shape public policies aimed at minimizing financial losses.

PI_NAMEs: SUNDERARAMAN, PREETI  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Address;Adult;Age;age-related disease;aging related disease;alertness;Alzheimer's Disease;Awareness;Behavior;career;Classification;Clinical;Cognitive;cognitive ability;Cognitive aging;cognitive change;cognitive task;Complex;computer scientist;Computers;Data;Data Collection;design;Development;digital;Dimensions;Electronics;Evaluation;executive function;Exhibits;Factor Analysis;financial decision making;financial exploitation;financial literacy;Foundations;Goals;Habits;Health;Impaired cognition;improved;Individual;informant;instrument;Interview;Knowledge;Learning;Life;literacy;Machine Learning;Measurement;Measures;Mentors;Mentorship;middle age;Mission;Monitor;Nerve Degeneration;neuroeconomics;Neuropsychology;novel;older adult;online course;Participant;Pathologic;Patients;Performance;Personal Satisfaction;Phase;Population;Predisposition;preservation;Psychologist;Psychometrics;Public Policy;rate of change;Research;Respondent;Review Literature;Safety;Services;Shapes;simulation;skills;Surveys;Techniques;Technology;Testing;Time;tool;Training;trend;United States Social Security Administration;user-friendly;Validity and Reliability;web site;Writing

PROJECT_TITLE: Modernizing the Assessment of Financial Decision Making: Development and Evaluation of a Simulated Online Money Management Task in Older Adults

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project narrative Systemic lupus erythematosus (SLE) is a chronic, multi-system disease in which the immune system damages the body's own organs and tissues. This project aims to uncover the mechanisms whereby human genetic variants conferring increased lupus risk impact B cell function and the production of pathogenic antibodies against self (termed autoantibodies). The long-term goal of these studies is to guide the development of new targeted therapies for the treatment of SLE.

PI_NAMEs: JACKSON, SHAUN WILLIAM (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Acceleration;Adaptive Immune System;Animals;Antibodies;Antigens;Apoptotic;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Autophagocytosis;autoreactive B cell;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Biochemical;Cell Lineage;Cell Physiology;Cells;cellular imaging;Chronic;Complex;Data;Defect;design;Development;Disease;disorder risk;Endosomes;Event;Exhibits;Future;Gene Deletion;Generations;Genes;Genetic Models;Genetic Polymorphism;genetic variant;genome wide association study;Genotype;Goals;Hematopoietic;Human;Human Genetics;humoral immunity deficiency;imaging approach;Immune;Immune system;Immune Tolerance;Immunization;Immunoglobulin Class Switching;Immunologics;In Vitro;in vivo;Individual;insight;Integrin alphaV;Integrin alphaVbeta3;Integrins;Investments;Knockout Mice;Ligands;Link;loss of function;loss of function mutation;LoxP-flanked allele;Lupus;Maps;Memory;Modeling;Mus;Myelogenous;Myeloid Cells;NADPH Oxidase;new therapeutic target;novel;Nucleic Acid Regulatory Sequences;Nucleic Acids;Odds Ratio;Organ;Oxidases;Pathogenesis;pathogenic autoantibodies;Pathogenicity;Pathway interactions;Peripheral Blood Mononuclear Cell;Phagocytes;Phagocytosis;prevent;Production;Publishing;Reactive Oxygen Species;Receptor Signaling;recruit;Regulation;response;Risk;risk variant;Signal Pathway;Source;Structure of germinal center of lymph node;System;systemic inflammatory response;Systemic Lupus Erythematosus;T-Lymphocyte;targeted treatment;Testing;Tissues;TLR7 gene;Toll-like receptors;trafficking;Untranslated RNA;Variant;Viral Antigens;Virus Diseases;Virus-like particle

PROJECT_TITLE: Impact of Loss-of-function NADPH Oxidase Variants on B cell Activation in SLE

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Alzheimer’s disease is a public health crisis in the US and a growing health disparity, with African Americans at disproportionate risk for the disease compared to non-Hispanic Whites. This project proposes to investigate earlier-life individual- and community-level stress exposures—adverse life circumstances and trauma (i.e., extreme poverty, residential instability, crime, police and community violence, incarceration, racial discrimination), mental disorders and their symptoms, and poor sleep (e.g., abnormal duration, fragmentation)—as determinants of known midlife risk factors for poor cognitive outcomes in later life in two predominantly African American cohorts followed longitudinally for 35 years. Results will help clarify links of stress exposures with estimated risk at midlife for later-life dementia, identify vulnerable subgroups for targeted prevention of Alzheimer’s disease and related disorders, elucidate the role of social inequities in determining racial disparities in dementia, and establish a midlife cognitive baseline for future longitudinal follow-up of this valuable cohort.

PI_NAMEs: REBOK, GEORGE W. (contact);SPIRA, ADAM PETER;THORPE, ROLAND J.

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Academic achievement;achievement test;actigraphy;Address;Adult;Affect;African American;African American population;Age;Aging;Alcohols;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Attention;Baltimore;Behavior;Biological;Biological Markers;C-reactive protein;CDKN2A gene;Child;Childhood;Chronic stress;Cognition;Cognitive;cognitive performance;cohort;Communities;community violence;conduct problem;Crime;Cyclin-Dependent Kinase Inhibitor;Data;Dementia;dementia burden;dementia risk;Diabetes Mellitus;Diagnosis;disorder risk;Drug usage;Early identification;early life stress;Education;Epigenetic Process;Exposure to;first grade;follow-up;Future;Genetic;Genetic Materials;Health;health disparity;Health protection;Home;Hyperlipidemia;Hypertension;Impaired cognition;Imprisonment;Individual;Inequity;Inflammation;Inflammatory;inflammatory marker;Interleukin-6;Intervention;Intervention Studies;Interview;late life;Length;Life;Life Cycle Stages;Link;Measures;Mental disorders;Methylation;middle age;modifiable risk;Modification;Not Hispanic or Latino;Obesity;Occupational;Outcome;Outcome Study;Participant;Pathway interactions;Physiological;Police;poor sleep;Poverty;prevent;Prevention;Prevention trial;preventive intervention;prospective;protective factors;Psychopathology;Public Health;Race;racial discrimination;racial disparity;Risk;Risk Estimate;Risk Factors;Risk Marker;risk variant;Role;Sampling;second grade;sex;Sleep;Sleep disturbances;Social support;Stress;stressor;Subgroup;substance use;Symptoms;telomere;TNF gene;Trauma;traumatic event;universal prevention;Wrist;young adult

PROJECT_TITLE: Earlier-Life Predictors of Midlife Risk Factors for Dementia: A 35-Year Follow-up

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(55)R]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE This MT PREP requests funds for postbaccalaureate research training to prepare them for entry into a PhD or DVM/Ph.D. doctorate degree program, and to increase the number of underrepresented groups entering careers in the biomedical sciences.

PI_NAMEs: ANDERSON, BROOKE ;ARGUESO, JUAN LUCAS ;JOHN, GILBERT H (contact);ZABEL, MARK D

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Admission activity;Aptitude;Bachelor's Degree;Biomedical Research;career;Clinical;Clinical Research;college;Colorado;Communication;Country;Creativeness;Data;Degree program;design;disabled;Disabled Persons;disadvantaged background;Discipline;Disparity population;Doctor of Philosophy;Doctor's Degree;doctoral student;education research;Educational workshop;Elements;Enrollment;Ethics;Ethnic Population;experience;Experimental Designs;Extramural Activities;Faculty;faculty mentor;Funding;Future;Goals;Grant;ideation;Individual;interest;Letters;matriculation;Measures;Medical;Mentors;Mentorship;Minority Groups;minority scientist;Monitor;Occupations;Outcome;peer;peer coaching;Performance;Philosophy;Postbaccalaureate;Preparation;programs;Publications;Qualifying;racial population;Recommendation;recruit;Reporting;Research;Research Training;Science;Scientist;skills;Social support;socioeconomic disadvantage;Students;success;Talents;Training;training opportunity;Training Programs;translational medicine;Translational Research;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Academy of Sciences;United States National Institutes of Health;Universities;Veterinary Medicine;Writing

PROJECT_TITLE: Multi-Track Post-Baccalaureate Research Education Program (MT PREP)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_NAME: NATIONAL OPINION RESEARCH CENTER

PHR: PROJECT NARRATIVE Surveillance is a cornerstone of public health, but no data system currently exists to monitor Alzheimer's disease and related dementias (ADRD). The ADRD surveillance system we propose to create will provide a vital resource to track progress towards the U.S. National Plan to Address Alzheimer's Disease goals, such as preventing ADRD and reducing ADRD diagnosis and management disparities. When completed, the new surveillance system will provide a public resource that the research community, advocacy groups, government, and non-governmental organizations can use in the fight against ADRD.

PI_NAMEs: REIN, DAVID B (contact)

PROGRAM_OFFICER_NAME: BHATTACHARYYA, PARTHA

PROJECT_TERMS: Address;Adult;Advocacy;Affect;Age;age group;Algorithms;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;American;beneficiary;care systems;Caring;Characteristics;Code;Cognition;Cognitive;Communities;comorbidity;cost;cost of dementia;County;COVID-19 impact;COVID-19 mortality;Data;Data Analyses;data infrastructure;Dementia;Diagnosis;Diagnostic;diagnostic value;Disparity;disparity reduction;Eligibility Determination;ethnic minority;Ethnic Origin;Evaluation;fighting;General Population;Geography;Goals;Government;Health;Health and Retirement Study;health disparity;human old age (65+);improved;Information Systems;innovation;Link;Long-Term Care;Low Income Population;Measures;Medicaid;Medical;Medicare;Medicare claim;Medicare/Medicaid;Methodology;Monitor;mortality;National Institute on Aging;Nongovernmental Organizations;Outcome;Patients;payment;Persons;Population;Predictive Value;Prevalence;prevent;Public Health;Race;racial minority;Research;Research Design;Research Personnel;Resources;Retirement;rural dwellers;Sensitivity and Specificity;service utilization;Services;sex;Sexual and Gender Minorities;sociodemographics;Source;Stratification Factors;Surveys;System;United States;Update;validation studies;web site;Work

PROJECT_TITLE: Developing and Evaluating a Surveillance System for Alzheimer's Dementia In the United States

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Narrative Neuromodulation by acetylcholine (ACh) plays a major role in regulating striatal circuits and downstream resulting behaviors. Alterations in cholinergic transmission in the striatum underlie numerous neurological diseases. A better understanding of the events linking acetylcholine release to its physiological actions will be significant as it has the potential to direct new strategies for the treatment of movement based neurological disorders.

PI_NAMEs: FORD, CHRISTOPHER PETER (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acetylcholine;Animal Model;Association Learning;Basal Ganglia;Behavior;cholinergic;Cholinergic Receptors;Corpus striatum structure;Data;Dendrites;Disease;Dopamine;dopaminergic neuron;Dystonia;Electrophysiology (science);Equilibrium;Event;extracellular;Functional disorder;Funding;Glutamates;Goals;Grant;Huntington Disease;Image;Interneurons;Link;Measures;Mediating;Metabotropic Glutamate Receptors;motivated behavior;motor learning;Movement;Movement Disorders;Muscarinic Acetylcholine Receptor;Muscarinics;Nerve Degeneration;Nervous System Disorder;Neurologic;Neuromodulator;Neurons;neuroregulation;Nicotinic Receptors;novel strategies;novel therapeutic intervention;optical sensor;Oxidopamine;Parkinson Disease;Pathway interactions;Physiological;Play;postsynaptic;postsynaptic neurons;Potassium Channel;presynaptic;receptor;Receptor Activation;Receptor Signaling;Regulation;Rewards;Role;Second Messenger Systems;sensor;Signal Transduction;Site;spatiotemporal;Synapses;Synaptic Receptors;Testing;transmission process;Viral;Work

PROJECT_TITLE: Regulation of Striatal Acetylcholine Transmission by Choinergic Interneurons


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed project will be the first large-scale study to examine HPV self-sampling among medically underserved Asian American women. Study findings will be valuable for informing future evidence-based programs designed to increase cervical cancer screening coverage among underscreened women who are unable to obtain clinic-based screening.

PI_NAMEs: FANG, CAROLYN Y. (contact);MA, GRACE X.

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Address;American;Asian Americans;Asian population;Belief;black women;Cervical Cancer Screening;Clinic;Collection;Communities;Community Health Education;community setting;cost;cost effectiveness;Cost Effectiveness Analysis;Cytology;Data;demographics;design;Education;Emerging Technologies;empowerment;Environment;Environmental Risk Factor;Ethnic Origin;evidence base;Evidence based program;Expectancy;experience;follow-up;Future;Goals;Guidelines;health care availability;Health Personnel;Health Promotion;Healthy People 2020;Hispanic Women;Hour;HPV screening;HPV-High Risk;Human Papillomavirus;implementation strategy;improved;Incidence;incremental cost-effectiveness;Individual;Insurance;Koreans;Language;Limited English Proficiency;Malignant neoplasm of cervix uteri;Mediator;Medical;medically underserved;mortality;Not Hispanic or Latino;Pap smear;Participant;Physical environment;Population;population health;post intervention;programs;psychosocial;racial population;Randomized;Recommendation;relative cost;Reporting;Resistance;Resource-limited setting;Resources;Sampling;screening;screening guidelines;screening participation;screening program;Self Efficacy;Site;social;social cognitive theory;Subgroup;Testing;Time;United States;United States Preventative Services Task Force;Vietnamese;Woman

PROJECT_TITLE: Evidence-Based Approach to Empower Asian American Women in Cervical Cancer Screening

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative These studies will define the degree to which humans generate antibody responses that are reactive to different enteroviruses, allowing prioritization of vaccine efforts to those viruses with poorer natural response. Human monoclonal antibodies that we isolate will help determine which structural parts of these viruses generate the most broadly reactive antibodies, allowing vaccine design to focus on authentically replicating these structures. Finally, the monoclonal antibodies themselves have potential for use in prevention or treatment of enterovirus infections causing disease.

PI_NAMEs: VOGT, MATTHEW R (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: acute flaccid myelitis;Adult;Animals;Antibodies;Antibody Response;Antibody Therapy;Antigens;B-Lymphocyte Epitopes;B-Lymphocytes;Binding;Blocking Antibodies;candidate validation;Cell Compartmentation;Cell Culture Techniques;Cell Surface Receptors;Cells;Child;China;Clinical;Complement;Complex;Cross Reactions;cross reactivity;Cryoelectron Microscopy;Data;design;Disease;Disease Outbreaks;Educational process of instructing;Enterovirus;Enterovirus 68;Enterovirus 71;Enterovirus Infections;Enzyme-Linked Immunosorbent Assay;Epidemiology;Epithelial Cells;Epitopes;experience;Fab Immunoglobulins;Foot Diseases;future epidemic;future outbreak;genomic RNA;Hand's disease;Hemagglutination;high throughput screening;Human;human disease;human monoclonal antibodies;Human poliovirus;Humoral Immunities;Hybridomas;Immune;Immunity;Immunize;Immunocompromised Host;in vivo;in vivo Model;Individual;Infection;Knowledge;Licensing;Life Cycle Stages;Maps;Memory B-Lymphocyte;Meningitis;Modeling;Molecular;Monoclonal Antibodies;Mouth Diseases;Movement;Mus;Myocarditis;neonatal sepsis;neutralizing antibody;Paralysed;Peripheral Blood Mononuclear Cell;Poliomyelitis;Poliovirus Vaccines;polyclonal antibody;Population;Positioning Attribute;preclinical development;preservation;prevent;Prevention;prophylactic;Quality Control;receptor;receptor binding;recombinant virus;Resolution;Respiratory Tract Infections;response;screening;Seroepidemiologic Studies;Serum;Structure;Surface;Symptoms;targeted treatment;Therapeutic Agents;therapy development;Vaccination;Vaccine Design;vaccine development;Vaccines;Viral;Virion;Virus;Virus Receptors;Virus-like particle;Work

PROJECT_TITLE: Human Antibody Cross-Reactivity in Non-Polio Enteroviruses


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative:  Currently, a substantial effort is focused on understanding the mechanisms regulating the induction of thermogenic beige adipocytes as a potential therapeutic target for increasing energy expenditure to reduce and/or prevent obesity and insulin resistance. Although humans have the capacity to induce thermogenic adipocytes, only 50% of adolescents and 10% of adults display cold inducible beige/brown adipocytes. In contrast, all humans are born with brown adipose tissue that begins to decline during the first decade of life and continues to decline throughout the normal lifespan. Similarly, brown adipose depots in mice decline both in mass and function starting at approximately 8-12 months of age and continue to decline throughout their remaining life span. Our preliminary data indicate that the decline brown adipose tissue mass and function results the activation of a Nlrp1 pyroptosis cell death pathway that is the focus of this new grant proposal.

PI_NAMEs: FENG, DAORONG ;PESSIN, JEFFREY E. (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Address;Adipocytes;adiponectin;Adipose tissue;Adolescent;Adult;Age Months;age related;age related decline;aged;Aging;Applications Grants;Autophagocytosis;Birth;Blood Vessels;Brown Fat;CASP1 gene;CASP3 gene;Cell Death;Cell membrane;Cell Nucleus;Cell Survival;Data;Development;Down-Regulation;energy balance;Energy Metabolism;Event;Familial generalized lipodystrophy;Female;Functional disorder;Gene Expression;gene therapy;Genetic;glucose metabolism;Homeostasis;Human;improved;inhibitor;Insulin Resistance;insulin sensitivity;interleukin-1beta-converting enzyme inhibitor;Knock-out;Knockout Mice;Life;life span;Ligands;lipid biosynthesis;male;Mediating;Mediator;Membrane Fusion;Membrane Lipids;Membrane Proteins;Metabolic;Mitochondria;Modeling;Molecular;Mus;Neurotrophic Tyrosine Kinase Receptor Type 3;neurotropic;normal aging;NTRK3 gene;obesity prevention;overexpression;paracrine;Pathway interactions;pharmacologic;Physiological;Play;preservation;prevent;Principal Investigator;Proteins;receptor;Receptor Protein-Tyrosine Kinases;Reporting;RNA;Role;Signal Pathway;Signal Transduction;SNAP receptor;SNAP23 gene;syntaxin 4;target SNARE proteins;therapeutic target;therapeutically effective;Thermogenesis;Time;Tissues;trafficking;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;Vesicle;Weight Gain;Wild Type Mouse

PROJECT_TITLE: Molecular Mechanism of Brown Adipose Tissue Regression

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DAVIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative Mesenchymal stem/stromal cells (MSC) are anti-inflammatory and immunomodulatory. They have capacity to enhance host immunity and support tissue repair during inflammatory diseases. HIV impairs host immunity and establishes latent reservoirs. This study will investigate the potential of MSCs in enhancing anti-viral mucosal immunity and tissue renewal for viral clearance in the SIV model of AIDS.

PI_NAMEs: DANDEKAR, SATYA  (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;adult stem cell;Allogenic;Animals;Anti-Inflammatory Agents;Antibodies;Antigen Presentation;antiretroviral therapy;antiviral immunity;Autologous;Automobile Driving;B-Lymphocyte Subsets;biomarker identification;Cells;Chronic;Clinical Trials;Color;Cytotoxic T-Lymphocytes;Dependovirus;Disease;Disease remission;efficacy evaluation;Environment;Flow Cytometry;Gene Expression;gene network;Gut associated lymphoid tissue;gut microbiota;Gut Mucosa;HIV;HIV Infections;Human;Immune;immune activation;Immune response;Immunity;Immunologics;Immunology;immunoregulation;Impairment;Individual;Inflammation;Inflammatory;inhibitor;Injury;innovation;Interruption;Lead;Lymphoid Follicle;Lymphoid Tissue;Macaca;Macaca mulatta;Measures;Mediating;Mesenchymal;Mesenchymal Stem Cells;metabolomics;Modeling;Molecular;Molecular Analysis;Mucosal Immunity;mucosal site;Mucous Membrane;nonhuman primate;novel;Pathogenicity;Patients;peripheral blood;Quantitative Reverse Transcriptase PCR;Recovery;repaired;response;Site;SIV;stem;stem cell biology;stem cell migration;stem cell therapy;Stem cell transplant;Stromal Cells;Structure;T-Lymphocyte;Testing;Therapeutic;therapeutic target;tissue regeneration;tissue repair;Viral;Viral Load result;Viral reservoir;Virus;Virus Inhibitors;Virus Replication

PROJECT_TITLE: "Corral and Kill" strategy for HIV eradication using MSC in an SIV model

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Services;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Primary Health Care;Radiation Oncology;Rare Diseases;Rehabilitation;Telehealth

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Secondary to the therapies that cured childhood cancer survivors, most will develop a chronic disease early in life. For example, survivors treated with abdominal or pelvic radiation are at significantly elevated risk of colorectal cancer (CRC) at a young age. The proposed study aims to reduce the morbidity and mortality faced by these survivors by testing a remote intervention aimed at promoting early CRC screening and detection.

PI_NAMEs: HENDERSON, TARA OLIVE (contact);KIM, KAREN E

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: Abdomen;adenoma;Adherence;Adult;Age;Age Years;arm;Cancer Center;Cancer Survivor;Cancer Survivorship;Carcinoma;Caring;childhood cancer survivor;Childhood Cancer Survivor Study;Childhood Cancer Treatment;Chronic Disease;cohort;Cohort Studies;Colonoscopy;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;comparative effectiveness;comparative efficacy;comparison control;Congresses;Consolidated Framework for Implementation Research;cost estimate;Detection;Development;digital;Dissemination and Implementation;DNA;Dose;Early Diagnosis;early onset colorectal cancer;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness study;Evaluation;experience;Exposure to;Family history of;Feces;follow-up;Future;General Population;Geography;Goals;Guidelines;high risk;Hybrids;implementation evaluation;implementation intervention;implementation process;implementation study;improved;improved outcome;incremental cost-effectiveness;Infrastructure;Institution;Intervention;Intervention Studies;Lesion;Life;Long-Term Survivors;Longterm Follow-up;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediator;Methods;mHealth;mhealth interventions;Morbidity - disease rate;mortality;Patients;Pediatric Oncology Group;Pelvis;Population;premalignant;Premature Mortality;Primary Care Physician;primary care provider;primary outcome;Provider;Radiation;Radiation therapy;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;remote intervention;Research;Resources;Risk;screening;screening guidelines;Secondary to;Survivors;survivorship;System;Target Populations;Testing;Text Messaging;therapy design;uptake;Work

PROJECT_TITLE: The ASPIRES Study: Activating Cancer Survivors and their Primary Care Providers to Increase Colorectal Cancer Screening


ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative These experiments will provide new knowledge on how serotonin contributes to pathology during sepsis, and what cooperative defense mechanisms exist to neutralize this serotonin and mitigate the pathology. This knowledge will help accelerate the development of novel therapeutic approaches to promote survival during sepsis.

PI_NAMEs: GALLANT, ROBERT MARC (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acceleration;Address;anti-fungal agents;Anti-viral Agents;Antibiotic Resistance;Antibiotics;Bacteremia;Biological;Blood Platelets;Circulation;Clinical;Communication;cytokine;Data;Defense Mechanisms;defense response;Development;Disease;Dose;Enzyme-Linked Immunosorbent Assay;Enzymes;Escherichia coli;Exhibits;experimental study;Flow Cytometry;Fractionation;Genes;genetic approach;Goals;Health;Health Promotion;High Pressure Liquid Chromatography;Host Defense;Immune;Immune response;Immune system;improved;Individual;Infection;Inflammation;Interleukin-10;Intraperitoneal Injections;Kidney;Knock-out;Knowledge;Lethal Dose 50;Lipids;Liver;Lung;Mentors;Metabolic;Metabolism;Microbe;Modeling;Molecular;Monoamine Oxidase A;Mus;Neurotransmitters;new pandemic;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Organ;overexpression;pathogen;Pathology;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Physiological;Platelet Activation;polymicrobial sepsis;Population;prevent;Process;Production;Regulation;repaired;Research;Resistance;Role;Scintillation Counting;Sepsis;Serotonin;Signal Transduction;skills;Staphylococcus aureus;Therapeutic;Training;transcriptome;Triglyceride Metabolism;uptake;Viral Vector;Virulence;Work

PROJECT_TITLE: The role of serotonin in cooperative defenses during polymicrobial sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-M(20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Dementia;Emergency Care;Lymphatic Research;Neurodegenerative;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Sleep Research;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative: The objective of this proposal is to understand how sleep disturbances affect recovery in youth presenting to the Emergency Department (ED) with mild traumatic brain injury (mTBI). We will use subjective and objective tools to measure sleep quality in a cohort of youth admitted to the ED with mTBI, and will correlate those measures with the presence of post-concussive symptoms at 4 weeks follow up. Additionally, we will study how sleep disturbances affect the glymphatic pathway, a network of perivascular spaces surrounding the cerebral vessels, which is associated with waste removal from the brain.

PI_NAMEs: PIANTINO, JUAN ANDRES (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: 18 year old;Accident and Emergency department;Accounting;actigraphy;Active Learning;Acute;Address;Admission activity;Affect;Age;age group;Alzheimer's Disease;Animal Model;Animals;Anxiety;Appearance;Award;Biological;Biometry;Blood Vessels;Brain;Brain Concussion;brain magnetic resonance imaging;career;Caring;Cerebrum;Child;Childhood;Clinical;cohort;Confusion;Contrast Media;Control Groups;Data;Data Analyses;design;Development;Devices;Emergency research;Equipment and supply inventories;Excision;Experimental Models;Fatigue;Fellowship;follow-up;Foundations;Functional disorder;Future;glymphatic dysfunction;glymphatic function;glymphatic system;Goals;Headache;Health;Human;Image;image processing;Impaired cognition;Impairment;Injury;insight;interstitial;Intervention;Intrathecal Injections;K-Series Research Career Programs;Knowledge;Link;Long-Term Effects;longitudinal analysis;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Mediator;meetings;Memory impairment;Mental Depression;Mentors;Methods;mild traumatic brain injury;Minor;Modeling;Moods;Morbidity - disease rate;Mycobacterium tuberculosis;neurophysiology;new technology;Normal Pressure Hydrocephalus;novel;Oregon;Orthopedics;Outcome;Outcome Study;participant enrollment;Pathology;Patients;Pediatric Neurology;Play;Population;Positioning Attribute;Post-Concussion Syndrome;prevent;Procedures;professor;Publishing;Recording of previous events;Recovery;Reporting;Research;Research Personnel;Research Training;Residencies;risk stratification;Rodent Model;Role;Science;skills;Sleep;Sleep Disorders;Sleep disturbances;sleep pattern;sleep quality;solute;Symptoms;Techniques;Testing;Therapeutic Intervention;tool;Training;Training Programs;Traumatic Brain Injury;United States;Universities;Vascular Dementia;wasting;Work;Youth

PROJECT_TITLE: A link between sleep-wake disturbances and enlarged perivascular spaces in youth with traumatic brain injury

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Disease

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Cholesterol accumulation is critical for the pathogenesis of nonalcoholic steatohepatitis (NASH) with fibrosis, a rising public health threat with no available drug treatment. This proposal aims to study the role of the cholesterol- associated GWAS locus EHBP1 in liver fibrosis in the context of NASH and explore the novel crosstalk between EHBP1-mediated cholesterol homeostasis and inflammation resolution. Successful completion of our proposed studies will help meet the critical clinical need for novel therapies that can prevent NASH progression to fibrosis.

PI_NAMEs: CAI, BISHUANG  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Address;Anabolism;analog;Attenuated;cell type;Cholesterol;Cholesterol Homeostasis;chronic liver disease;Cirrhosis;Cirrhotic hepatocyte;Clinical;Clinical Trials;cytokine;Data;Data Set;Disease;Docosahexaenoic Acids;FDA approved;Fibrosis;FPR2 gene;Genetic Transcription;genome wide association study;Hepatic;Hepatocyte;High Prevalence;Human;Human Genome;human RNA sequencing;in vivo;Infiltration;Inflammation;Inflammatory;innovation;insight;Interruption;Kupffer Cells;LDL Cholesterol Lipoproteins;Link;Liver;Liver Fibrosis;Low Density Lipoprotein Receptor;Macrophage;Mediating;Mediator;Molecular;Morbidity - disease rate;mortality;Mus;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;novel therapeutics;Obesity Epidemic;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Population;Positioning Attribute;Prevalence;prevent;Primary carcinoma of the liver cells;Process;Protein Binding Domain;Public Health;Publishing;receptor;Regulation;Research Personnel;Resolution;response;Role;sensor;Signal Transduction;Single Nucleotide Polymorphism;single-cell RNA sequencing;Stress;Testing;Therapeutic;therapeutic target;transcriptome sequencing;uptake

PROJECT_TITLE: Disturbed Crosstalk between Cholesterol Homeostasis and Inflammation Resolution in NASH

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Patient Safety;Precision Medicine;Prevention

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The ECOG-ACRIN Integrated Thoracic Malignancies Translational Sciences Center brings together a team of outstanding researchers in both translational and clinical sciences to discover biomarkers and develop novel treatment approaches for lung cancer within the National Clinical Trials Network.

PI_NAMEs: CARBONE, DAVID P.;LEAL, TICIANA  (contact);RUDIN, CHARLES M.

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: American College of Radiology Imaging Network;Area;Award;Biological Markers;biomarker development;biomarker discovery;biomarker driven;biomarker evaluation;BRAF gene;cell free DNA;Center for Translational Science Activities;checkpoint inhibition;chemotherapy;Chest;Clinical;clinical care;Clinical Data;Clinical Sciences;Clinical Trials;Clinical Trials Network;cohort;Collaborations;Combined Modality Therapy;companion diagnostics;Detection;Development;Disease;driver mutation;drug development;Early Diagnosis;Eastern Cooperative Oncology Group;EGFR inhibition;Enrollment;Epidermal Growth Factor Receptor;epigenetic marker;epigenomics;Excision;Funding;Genomics;Goals;Grant;Immunologic Markers;Immunotherapy;improved;improved outcome;innovation;Institution;Leadership;Lung;lung cancer screening;Lung Neoplasms;Malignant neoplasm of lung;Malignant neoplasm of thorax;Molecular;Molecular Abnormality;Molecular Analysis;Mutation;National Clinical Trials Network;next generation;Non-Small-Cell Lung Carcinoma;novel;novel marker;novel strategies;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;personalized medicine;phase 3 study;Pilot Projects;Plasma;Plasma Cells;Play;Poly(ADP-ribose) Polymerase Inhibitor;Precision Medicine Initiative;Precision therapeutics;Prevention;Process;programmed cell death ligand 1;programs;prospective;Proteomics;Recurrence;Research;Research Personnel;Residual Neoplasm;Resistance;risk prediction;risk stratification;Role;ROS1 gene;Science;Selection for Treatments;small cell lung carcinoma;Specimen;STK11 gene;targeted agent;targeted treatment;Technology;Testing;Time;Translational Research;tumor;Work

PROJECT_TITLE: ECOG-ACRIN Thoracic Malignancies Integrated Translational Science Center


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Patient Safety;Prostate Cancer;Urologic Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: UROLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: This project is relevant to public health because it tests a molecular-targeted PET agent, 68Ga-P16-093, to guide prostate cancer surgery. When imaging confirms the absence of disease near the nerves and muscles adjoining the prostate, those key structures can be preserved, resulting in improved urinary and sexual quality- of-life. In keeping with the NIH’s mission, this research effort focuses on “improved imaging technologies and surgical interventions...in combination with standard of care therapies.”

PI_NAMEs: BAHLER, CLINTON DAVID (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Aftercare;Antigen Targeting;Biopsy;Blinded;Cancer Control;Cancer Death Rates;Cancer Patient;cancer recurrence;cancer surgery;Clinical;clinical care;comparison group;Control Groups;Detection;Disease;disorder control;Drops;Enrollment;Ensure;Erectile dysfunction;European;Excision;Extraprostatic;Fire - disasters;FOLH1 gene;Friends;Goals;Image;Image-Guided Surgery;Imaging technology;improved;Incontinence;Individual;innovation;Life Experience;Location;lymph nodes;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Metastatic Prostate Cancer;Microscopic;Mission;Modality;Modification;Molecular Target;Monitor;Muscle;Nerve;nerve damage;Newly Diagnosed Disease;Operative Surgical Procedures;Outcome;Outcome Measure;Pathology;Patient-Focused Outcomes;Patients;Pelvis;Performance;Phase;Phase II Clinical Trials;Population;Positron-Emission Tomography;predictive tools;preservation;Prostate;prostate cancer survivors;Prostatectomy;Public Health;Quality of life;Radiation therapy;Radiology Specialty;Radiopharmaceuticals;Randomized;randomized trial;Randomized, Controlled Trials;Reader;Recurrence;Regrets;Reporting;Research;Research Personnel;Risk;Side;side effect;spared nerve;standard of care;Structure;Structure of capsule of prostate;Surgeon;Surgical margins;Survivors;targeted agent;technology intervention;Testing;tool;Tracer;treatment planning;Treatment Side Effects;Tumor Markers;United States National Institutes of Health;urinary;Urinary Incontinence;Validation;whole body imaging

PROJECT_TITLE: PSMA-PET to Guide Prostatectomy: Can PSMA-PET Appropriately Modify Surgery, Reduce Nerve Damage and Optimize Quality-of-Life?

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Clinical Research;Health Services;Kidney Disease;Organ Transplantation;Transplantation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Medicare pays for more than 70% of pretransplant services before kidney transplantation ($100,000 per kidney transplant in 2017). These services include evaluating patients with chronic kidney disease for addition to the waitlist, medical surveillance of candidates on the waitlist, and living donor evaluation and procurement. The proposed research will investigate how much each of these services cost and how much they are related to outcomes; the results will inform the transplant community and Medicare where value lies in the complicated process of pretransplant care and which high-value services to prioritize.

PI_NAMEs: CHENG, XINGXING SHELLEY (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Affect;care coordination;care costs;Caring;Case Mixes;Chronic Kidney Failure;Clinical Investigator;Communities;comorbidity;Coronary Arteriosclerosis;cost;Cost Analysis;cost estimate;Cost Savings;crosslink;Data;Databases;Diagnostic tests;Dialysis procedure;econometrics;End stage renal failure;Environment;ethnic minority;Evaluation;Expenditure;Fee-for-Service Plans;Grant;Health;Healthcare;Hospital Costs;Hospitalization;improved;indexing;Insurance Carriers;Insurance Coverage;Kidney;Kidney Transplantation;Laboratories;Link;Living Donors;living kidney donor;Maintenance;Medical Surveillance;Medicare;Mentored Patient-Oriented Research Career Development Award;Methodology;Minority;Minority Status;mortality;Myocardial Ischemia;Nephrectomy;Organ;Outcome;Patients;payment;Persons;Policies;Population;Practice Guidelines;Price;Privatization;Procedures;Process;programs;Provider;Quality of Care;racial minority population;Reporting;Research;Rest;Role;screening;Services;sex;Time;Training;Transplant Recipients;transplant registry;Transplantation;United States;Wages;Waiting Lists

PROJECT_TITLE: The Role of Pretransplant Services on Outcomes and Costs in Kidney Transplantation

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Primary Health Care;Telehealth

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Glaucoma is the leading cause of irreversible vision loss globally. A new screening paradigm that provides patients with better access to the technology needed to detect glaucoma is urgently needed. This proposal aims to develop a cost-effective technology that integrates optical coherence tomography, the clinical standard for detecting glaucoma, with smartphone devices that can be operated at the point-of-care in novel screening contexts.

PI_NAMEs: BOWDEN, AUDREY KYNSELLA (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Adult;Affect;aged;Agreement;Algorithmic Software;Ambulatory Care;Appointment;Blindness;Caring;Cellular Phone;Clinic;Clinical;Clinical Research;Communities;cost;cost effective;Data;Democracy;Detection;Deterioration;Devices;Diabetes Mellitus;Diagnosis;Disease;Early treatment;Effectiveness;Endocrinology;Ethnic Origin;Evaluation;experience;Eye;Family;Glaucoma;glaucoma test;global health;Health;health care quality;health care settings;Health Fairs;healthy volunteer;high resolution imaging;high risk;Image;imaging system;Imaging Techniques;Improve Access;innovation;instrument;Insurance;Laboratories;Latino;Lie Detection;light weight;Manuals;Measurement;Measures;Modeling;modifiable risk;Monitor;Morphologic artifacts;Motion;Nature;new technology;novel;Ophthalmologist;Ophthalmology;Optic Disk;Optic Nerve;Optical Coherence Tomography;optical disc;Outcome;outpatient programs;Outpatients;Patients;Performance;Peripheral;Persons;Pharmacy facility;Physiologic Intraocular Pressure;Pilot Projects;point of care;Population Study;portability;preservation;Prevalence;Primary Care;primary care clinic;primary care provider;Primary Open Angle Glaucoma;programs;prototype;Qualitative Methods;Qualitative Research;Recording of previous events;Research;Resources;retinal imaging;retinal nerve fiber layer;Risk;Risk Factors;Role;Scanning;screening;screening program;sensor;Services;Signal Transduction;Site;smartphone based device;stem;System;Technology;telehealth;Telemedicine;Thick;Time;Training;Travel;Underserved Population;user-friendly;Vision;Visualization;Work

PROJECT_TITLE: smartOCT:  a low-cost technology to detect and monitor glaucoma in outpatient and primary care centers


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer;Natural Products;Rare Diseases

PHR: Metastasis is the leading cause of death in cancer patients, but the mechanisms such as how metabolic rewiring and metastasis interplay remain unclear. Through a customized mitochondrial RNAi screen, we found that alpha- aminoadipate semialdehyde synthase (AASS) and its product 2-aminoadipate (2-AAA) are essential for invasion and metastasis of various human cancers. In this proposal, we will examine by which AASS signaling coordinatively promote tumor metastasis by providing cellular and metabolic advantages to cancer cells and validate therapeutic efficacy of targeting AASS signaling pathway as a novel anti-metastasis therapy.

PI_NAMEs: KANG, SUMIN  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: activating transcription factor 1;Attenuated;Binding Proteins;Biological Assay;cancer cell;Cancer cell line;Cancer Patient;cancer therapy;cancer type;Cause of Death;Cells;Clinical;cohort;Data;Development;Disseminated Malignant Neoplasm;Down-Regulation;Enzymes;Equilibrium;FDA approved;Gene set enrichment analysis;Genes;genomic profiling;Genomics;Glean;Head and Neck Cancer;Head Cancer;HGF gene;Homeostasis;Human;In Vitro;in vivo;inhibitor;insight;Invaded;kinase inhibitor;Libraries;Link;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Metabolic;Mitochondria;Molecular;Neck Cancer;Neoplasm Metastasis;neoplastic cell;novel;Oxidation-Reduction;Pathway interactions;patient derived xenograft model;Patients;Phosphotransferases;Play;Prognostic Marker;Proteins;Research;RNA Interference;RNA interference screen;RNA Splicing;saccharopine;Series;Signal Pathway;Signal Transduction;small hairpin RNA;small molecule;Solid Neoplasm;Tannic Acid;therapeutic target;transcription factor;transcriptome sequencing;transcriptomics;Treatment Efficacy;tumor;Tumor Promotion;Tumor Tissue;TXN gene;Up-Regulation;upstream kinase;Variant;XBP1 gene;Xenograft procedure

PROJECT_TITLE: Decoding and targeting saccharopine pathway in cancer metastasis

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Project Narrative: The overall goal of this new Metabolic Basis of Disease center is to facilitate the growth of young intellectual talent, foster collaborations, and build the scientific infrastructure that will promote biomedical research discoveries that will enhance our understanding of the metabolic aspects of various disease states.

PI_NAMEs: STEPHENS, JACQUELINE M (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Address;Animal Behavior;Animal Experimentation;animal facility;Animal Model;Anxiety;Award;bioimaging;Biomedical Research;Career Choice;career development;Cells;Cellular biology;Centers of Research Excellence;Chronic Disease;Collaborations;Comparative Biology;Development;Diabetes Mellitus;Disease;Eating;Environment;Experimental Designs;Faculty;Faculty Recruitment;faculty research;Female;Fostering;Funding;Genomics;Goals;Growth;Growth and Development function;Health;Human;improved;Infrastructure;innovation;Institution;interest;Knowledge;Learning;life span;Light;Louisiana;Malignant Neoplasms;Martes zibellina;Mentors;Mentorship;Metabolic;metabolic abnormality assessment;metabolic phenotype;Methodology;Methods;Microscopy;Mission;Molecular;Phase;pre-clinical;pre-clinical research;Pre-Eclampsia;programs;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;Services;skills;Talents;Tissues;Training;Training Support;transcriptome sequencing;Transgenic Mice;tumor metabolism

PROJECT_TITLE: Metabolic Basis of Disease


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Achievement;Advisory Committees;Award;Basic Science;Biomedical Research;Businesses;career development;Centers of Research Excellence;Communication;Core Facility;Disease;Etiology;experience;Extramural Activities;Faculty;Faculty Recruitment;falls;Floor;Fostering;Funding;Goals;Hearing;implementation strategy;Infrastructure;Laboratories;Leadership;Louisiana;meetings;member;Mentors;Mentorship;Metabolic;Metabolic Diseases;method development;Mission;Molecular;pre-clinical;Productivity;programs;Progress Reports;Records;recruit;Research;Research Activity;Research Project Grants;Resources;Running;Site Visit;Teleconferences;Voice;web site;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: MORRISON, CHRISTOPHER D (contact)

PROJECT_TERMS: Acceleration;Animal Experimentation;Animal Model;Animals;Area;Award;Behavioral;Biomedical Research;career;Centers of Research Excellence;Communities;Data Analyses;Development;Disease;Disparate;Ensure;Environment;Equipment;experience;experimental analysis;Experimental Designs;experimental study;Faculty;Gene Modified;Genetic Models;Goals;Health;human disease;human model;in vivo;Infrastructure;innovation;Knowledge;Laboratories;Mentors;Metabolic;Metabolic Diseases;metabolic phenotype;Methodology;Mission;Mus;novel;Operative Surgical Procedures;Phenotype;pre-clinical;Pre-Clinical Model;pre-clinical research;Procedures;Productivity;protocol development;Reproducibility;Research;research faculty;Research Personnel;Research Project Grants;Resources;Scientist;skills;supportive environment;Techniques;Testing;Tissue Banks;Training;Work

PROJECT_TITLE: Preclinical


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PI_NAMEs: SALBAUM, J MICHAEL (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Applications Grants;bioimaging;Biological;Biomedical Research;Biomedical Technology;career;Cells;Centers of Research Excellence;Complex;Computer software;cost;Data;Data Collection;Data Set;design;Disease;Ensure;Environment;Equipment;Etiology;Evaluation;Experimental Designs;experimental study;Expression Profiling;functional genomics;Funding;Future;Gene Expression;gene product;Generations;Genomic approach;Genomics;Goals;Histology;Human Resources;imaging approach;imaging modality;Individual;Informatics;insight;instrumentation;Knowledge;Laboratories;Leadership;Light;Maintenance;Measurement;Mentors;Metabolic;Methods;Microscopy;Modernization;Molecular;new technology;Outcome;Ownership;Pathogenicity;Principal Investigator;Productivity;protocol development;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;RNA;Running;Science;Secure;single-cell RNA sequencing;skills;Solid;sound;success;Systems Biology;Technical Expertise;Technology;Three-Dimensional Imaging;Tissues;United States National Institutes of Health;Visualization

PROJECT_TITLE: Molecular Mechanisms


NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences

ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: MO

PHR: Project Narrative At the molecular level, how memory formation is gated such that only some but not all experiences result in long- lasting memories, is an important unanswered question. The proposed study intends to investigate how intron retention controls expression of memory-related proteins to confer selectivity to long-lasting memory. We aim to determine how splicing machinery senses internal and external stimuli, identify trans-acting factors and regulatory sequence motifs, and the consequences of intron retention in memory formation and consolidation. These studies will provide the first detailed insight of intron retention in adult nervous system.

PI_NAMEs: SI, KAUSIK  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Acute;Address;Adult;Alternative Splicing;Animals;Behavioral;Behavioral Assay;Binding;Binding Proteins;Biochemical Process;Biological Assay;Brain;candidate identification;Cell Nucleus;cis acting element;Code;crosslink;Cues;Disease;Drosophila genus;Event;Excision;experience;fly;Food;Gene Expression;Genes;genetic manipulation;Genetic Transcription;genome-wide analysis;Grant;Hunger;Immunoprecipitation;Impairment;insight;Introns;Large-Scale Sequencing;Lead;Learning;long term memory;Maintenance;MAP Kinase Gene;Measures;Mediating;Memory;memory retention;Messenger RNA;Molecular;Mus;mutant;Mutate;Mutation;Nervous System;Nervous System Physiology;Neurons;novel;Nucleotides;Odors;Organism;p38 Mitogen Activated Protein Kinase;Pathway interactions;Phosphoproteins;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Poly A;Poly(A)+ RNA;prevent;prion-like;Process;protein aggregation;protein expression;Protein Isoforms;Protein Splicing;Proteins;Proteomics;Quality Control;Regulation;Reporting;RNA;RNA Splicing;RNA-Binding Proteins;Role;Sensory;sensory stimulus;Signal Transduction;Site;Stimulus;synaptic function;Synaptosomes;Terminator Codon;tool;Training;Trans-Activators;Transact;Transcript;transcriptome;transcriptome sequencing

PROJECT_TITLE: Mechanism and consequence of intron-retention in the adult brain

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Brain Disorders;Eye Disease and Disorders of Vision;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE The retina, like most other tissues, maintains a physiologically optimal concentration of cholesterol by balancing local (de novo) cholesterol synthesis, vs. uptake from extraretinal sources (e.g., blood-borne lipoproteins, generated in the liver) and export— a process called “cholesterol homeostasis”. Dysregulation of this process leads to profound pathologies, such as Smith-Lemli-Opitz syndrome (SLOS), which can compromise retinal structure and function. This project seeks to further define how cholesterol homeostasis is achieved by the retina, utilizing a combination of novel, genetically altered mice (where cholesterol synthesis has been blocked in a cell type-specific manner) and in vitro cell culture studies (using SLOS patient-derived RPE cells, which exhibit defective autophagy), and to test candidate drugs that can rescue the autophagic defect, as a prelude to testing their ability to rescue retinal degeneration in the novel mouse models of SLOS to be generated.

PI_NAMEs: FLIESLER, STEVEN J. (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 7-dehydrocholesterol;7-dehydrocholesterol reductase;Ablation;Affect;Age;Alleles;Antioxidants;Astrocytes;Autophagocytosis;AY9944;Biological Assay;Biological Models;Biology;Blood;Cell Culture Techniques;Cell Death;Cell Line;cell type;Cells;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;Cholesterol Synthesis Inhibition;Defect;Dehydrocholesterols;Development;Diet;Disease;disease-in-a-dish;drug candidate;Enterobacteria phage P1 Cre recombinase;Equilibrium;Eukaryotic Cell;Exhibits;Exons;Family;Future;Gender;Genes;Genetic;Glial Fibrillary Acidic Protein;Goals;Hepatocyte;Histology;Homeostasis;Human;improved;In Vitro;in vivo;induced pluripotent stem cell;Inherited;inhibitor;Knock-out;Knockout Mice;Lipoproteins;Liver;LoxP-flanked allele;Measures;Metabolic Diseases;Methods;Modeling;Molecular;Monitor;Morphology;mouse model;Muller's cell;Mus;Mutation;myelination;Neural Retina;Neuroglia;Niacinamide;novel;Online Mendelian Inheritance In Man;Optic Nerve;outcome prediction;Oxidative Stress;Oxidoreductase;Pathology;patient derived induced pluripotent stem cells;Patients;Phagocytes;Phagosomes;Photoreceptors;Physiological;Process;Rare Diseases;Rattus;Reporter;Resources;Retina;Retinal Degeneration;Retinal Diseases;retinal neuron;retinal rods;rho;Rod Outer Segments;Role;Serum;Sirolimus;Smith-Lemli-Opitz Syndrome;Source;stable isotope;sterol homeostasis;Sterols;Structure;Testing;Therapeutic Intervention;therapeutically effective;Time;Tissues;uptake;Wild Type Mouse

PROJECT_TITLE: Cholesterol homeostasis in the vertebrate retina

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]