ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

PHR: The Center for Access and Delivery Research and Evaluation (CADRE) is seeking to renew its Center of Innovation (COIN) funding to advance research and improve access for Veterans. We aim to build upon our existing expertise, established operational partnerships, and long-term research objectives through prioritizing five overarching goals that align with our focused areas of research and emerging priorities. GOAL 1: Improve access to high quality care for rural Veterans through innovative applications of telehealth in specialty care, community care, and dual use. GOAL 2: Develop and evaluate interventions targeting the multidrug-resistant organism crisis. GOAL 3: Expand efforts in developing innovative health services research in three additional areas: (1) women’s health, (2) epidemic opioid use and substance use disorders, and (3) cardiovascular outcomes. GOAL 4: Continue the Center’s success in supporting mentored career development. GOAL 5: Promote Veteran engagement with recognition that Veterans are experts on Veteran experience.

PI_NAMEs: PERENCEVICH, ELI N (contact)

PROJECT_TERMS: Address;Area;barrier to care;Cardiovascular system;career development;Caring;Centers for Disease Control and Prevention (U.S.);Cities;Communities;Community Healthcare;connected care;design;digital intervention;Endocrinologist;Enrollment;Equity;Evaluation;experience;Face;Fertility;Funding;Goals;health care availability;Health Services Research;Healthcare Systems;Improve Access;improved;innovation;Internet;Intervention;Iowa;Leadership;medical specialties;meetings;Mentors;multi-drug resistant pathogen;operation;opioid epidemic;opioid use;Outcome;pharmacy benefit;Poverty;Prevention;Provider;Publishing;Quality of Care;Recommendation;reproductive;Research;Research Personnel;Research Priority;Resources;Rural;rural area;Rural Health;rural setting;Scientist;Services;Substance Use Disorder;success;telehealth;Universities;Veterans;Women's Health;Women's Health Services

PROJECT_TITLE: Center for Access & Delivery Research and Evaluation (CADRE)


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: The goal of the Durham Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT) is to enhance the Veterans Health Administration's (VHA) ability to continually improve health care and optimize Veteran wellbeing and independence. ADAPT will lead innovative research on promoting and sustaining healthy lifestyles, improving access through virtual care, and optimizing Veteran function and independence. Working closely with VA and non-VA partners, ADAPT investigators will apply and advance state-of-the-art methods, translate research findings into meaningful practice change, and train the next generation of VA researchers. ADAPT will play a vital role in helping VHA meet the challenges of providing timely, coordinated, consistently high-quality care to more than 9 million Veterans each year.

PI_NAMEs: HASTINGS, SUSAN NICOLE (contact)

PROJECT_TERMS: Acceleration;Address;Area;Behavior;burden of illness;care systems;career development;Caring;Clinical;clinical care;Collaborations;Communities;Data Sources;design;Development;Educational workshop;effectiveness evaluation;Effectiveness of Interventions;Ensure;experience;Face;Family;Fostering;Funding;Goals;Grant;Health behavior;health care availability;health care service organization;Health Services;Health Services Research;Health system;Healthcare;Healthcare Systems;healthy lifestyle;implementation research;Improve Access;improved;Individual;innovation;Lead;Leadership;Life;Long-Term Care;Mentorship;Methods;Modeling;Names;next generation;novel;Observational Study;Personal Satisfaction;Phase;Physicians;Pilot Projects;Play;Policies;Postdoctoral Fellow;Pragmatic clinical trial;Process;Quality of Care;Recording of previous events;Research;research and development;Research Infrastructure;Research Personnel;research study;resilience;Resources;Role;routine practice;Science;social factors;Time;Training;Translating;Translations;Veterans;Veterans Health Administration;virtual healthcare;Work;World Health Organization

STUDY_SECTION_NAME: HCN1 COIN REVIEW[HCN1]


ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: The Veterans Health Administration (VA) provides care for individuals who are more likely to be racial and ethnic minorities, older, and poorer than the general population. Although VA provides a health care safety net, disparities in health and health care exist for many vulnerable Veteran populations and are associated with increased risks of disability, illness, and death. In addition to individual, provider, and health system factors, disparities may originate outside of the health care system and involve personal behaviors and social and community influences. As a health system committed to delivering high-quality, equitable care to all Veterans, VA must identify vulnerable populations, understand the root causes of disparities, and assess interventions to eliminate them. The Center for Health Equity Research and Promotion's mission is to advance the quality and equity of health and health care for vulnerable Veterans.

PI_NAMEs: FINE, MICHAEL JONAH (contact);LONG, JUDITH A

PROJECT_TERMS: Address;behavioral economics;Big Data;Caring;Cessation of life;Clinical;clinical care;clinical epidemiology;Clinical Trials;Collaborations;Communities;community advisory board;Community Healthcare;Data Analyses;Decision Analysis;design;Development;disability risk;Discipline;Disparity;Ensure;Equity;ethnic minority;General Population;Genomics;Goals;Health;Health behavior change;health disparity;health equity;Health equity research;Health Services Research;Health system;Healthcare;Healthcare Systems;implementation science;improved;Individual;Infrastructure;innovation;Institution;Intervention;Knowledge;Leadership;Medical center;medical specialties;medication safety;Mentors;Meta-Analysis;Methods;military veteran;Mission;Outcome;Pattern;Pennsylvania;Personal Behavior;Pharmacologic Substance;pharmacy benefit;Policies;Program Development;programs;Provider;Psychometrics;Publications;Qualitative Research;racial minority;Records;Research;Research Personnel;Research Training;Safety;safety net;Scientific Advances and Accomplishments;Services;Site;social;Technology Assessment;Therapeutic;tool;Training;Training and Education;Translating;Universities;Veterans;Veterans Health Administration;Vulnerable Populations;Work

PROJECT_TITLE: Center for Health Equity Research and Promotion (CHERP)


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Given Veterans' increasing choices about where and how they receive care, successful coordination of care will require improving effective communication among a variety of individuals and entities, as well as improved management and use of health information. This project supports the Center for Health Information and Communication, of the U.S. Department of Veterans Affairs Health Services Research & Development Service. The Center's mission is to improve Veterans' health care through innovative research on health information, technology, and communication. The Center's vision is to improve Veterans' health through innovative applications of health information and health information systems that serve the population-based and interpersonal needs of patients and health professionals. The Center will generate knowledge about the impact of the Department's investment in health information technology, and will determine how systems-based and interpersonal communication of health information can improve delivery and outcomes of care.

PI_NAMEs: WEINER, MICHAEL  (contact)

PROJECT_TERMS: Address;alternative treatment;Area;cancer care;care coordination;care outcomes;career development;Caregivers;Caring;chronic pain;chronic pain management;Clinical;clinical decision support;clinical practice;Communication;Communities;computer human interaction;connected care;Decision Making;Dissemination and Implementation;Documentation;Electronic Health Record;Foundations;Funding;Goals;Health;health application;health communication;Health Information System;health information technology;Health Professional;Health Sciences;Health Services Research;Health Technology;Healthcare;improved;Individual;Information Management;innovation;Investments;Knowledge;Mediation;Mental disorders;Mental Health;Mentors;Mission;Office Management;operation;Opioid;Outcome;Pain management;Patients;person centered;Personal Communication;Pharmaceutical Preparations;Policies;population based;Positioning Attribute;programs;Provider;Publications;Research;research and development;Safety;Science;Scientist;Services;skills;Stroke;System;Technology;tool;Translations;Veterans;Veterans Health Administration;virtual;Vision;Work


ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: The Center for Mental Healthcare & Outcomes Research (CeMHOR) is an HSR&D Center of Innovation whose mission is to optimize health and well-being of Veterans through innovative research to improve access to and engagement in evidence-based care for mental health and substance use disorders and prevent suicide. CeMHOR accomplishes its mission by partnering directly with Veterans, clinical leaders, and front-line providers to develop feasible and effective interventions to address top VA and national priorities. CeMHOR expertise in implementation science leads to widespread uptake of these interventions. CeMHOR investigators are also experts in rural health and community engagement. CeMHOR research will apply this expertise to include Veterans who are not receiving VA care, as well as those who use VA services but do not fully engage in needed care. In addition to two focus areas, mental health care access/engagement and suicide prevention, investigators conduct research to address opioid misuse and abuse and advance implementation science.

PI_NAMEs: OWEN, RICHARD R. (contact)

PROJECT_TERMS: Address;Ambulatory Care Facilities;American;Area;Arkansas;Awareness;behavioral health;career development;Caring;clay;Clergy;Clinical;Collaborations;Communities;community college;community engagement;Community Outreach;community setting;Demographer;design;Development;effective intervention;Effectiveness;Epidemiologist;Evaluation;evidence base;Federally Qualified Health Center;gaps in access;Goals;Health;health care availability;Health Services;Health Services Research;Healthcare Systems;implementation intervention;implementation science;Improve Access;improved;innovation;Intervention;Knowledge;Location;Managed Care;Medical;Mental disorders;Mental Health;mental health center;Mental Health Services;Mentors;Methods;Mind;Mission;Modeling;opioid abuse;opioid misuse;opioid use disorder;Outcomes Research;peer support;Personal Satisfaction;Pharmacists;Prevention;Prevention strategy;Primary Care;Professional counselor;programs;Provider;Psychiatrist;Psychologist;Research;Research Personnel;Resources;Risk;Rural;rural area;Rural Community;Rural Health;Science;Services;Social Workers;sociologist;Substance Use Disorder;Suicide prevention;Testing;Training;Translating;Universities;uptake;Veterans;virtual healthcare;Work


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: The mission of the Center for Care Delivery and Outcomes Research (CCDOR) is to develop and evaluate interventions and implementation strategies that improve health care delivery, Veteran engagement in health care, and Veterans' health and functioning in their communities. CCDOR's vision is to elevate the quality, consistency and equity of health care and outcomes for all Veterans through innovative health services and implementation research. CCDOR is a vibrant health services research center of 26 core investigators leading research in Trauma Recovery (Priority 1) and Chronic Pain and Opioid Harms Reduction (Priority 2), as well as conducting and promoting research in additional areas including cancer prevention and control, health aging, and other timely topics. CCDOR has deep and strong partnerships with VA Program Offices, including the Office of Mental Health and Suicide Prevention, the National Center for PTSD, and National Pain Management. These and other partnerships ensure the value and impact of Center research.

PI_NAMEs: FU, STEVEN  (contact)

PROJECT_TERMS: acronyms;Aging;Area;Cancer Control;cancer prevention;care delivery;care outcomes;chronic pain;Communities;community based participatory research;community engagement;data management;Dedications;Disease;Ensure;Equitable healthcare;Evidence based practice;experience;Family;functional outcomes;Goals;Harm Reduction;Health;health care delivery;Health Services;Health Services Research;health training;Healthcare;Healthcare Systems;healthy aging;implementation research;implementation strategy;improved;Informatics;innovation;Intervention;Mental Health;Mentors;Methodology;Methods;Mission;Names;Opioid;Outcome;Outcomes Research;Pain management;Pain Research;Positioning Attribute;Post-Traumatic Stress Disorders;preservation;programs;Research;Research Personnel;Resources;Services;statistics;Strategic Planning;Structure;success;Suicide prevention;Training;Trauma;Trauma recovery;Veterans;Vision


ORG_CITY: ANN ARBOR

ORG_STATE: MI

PHR: Not applicable

PI_NAMEs: KERR, EVE A (contact)

PROJECT_TERMS: Achievement;Adverse event;Alcohols;Area;Award;behavioral economics;Cannabis;care coordination;care delivery;career;Caring;Chronic;Cladribine;Clinical;clinical center;Clinical Management;Collaborations;Communities;Community Healthcare;Complex;Critical Illness;Data Collection;Development;digital data;Disease Progression;disorder prevention;Effectiveness;experience;Family;Funding;Future;Health;Health Promotion;Health Services Accessibility;Health Services Research;Healthcare;Healthcare Systems;high risk;Homogeneously Staining Region;Hospitalization;implementation research;improved;Infrastructure;innovation;Inpatients;Intervention;investigator training;Knowledge;Measurement;Measures;Mental Health;mHealth;Michigan;Mission;Modernization;multidisciplinary;opioid misuse;Outcome;patient engagement;patient oriented;Patient Outcomes Assessments;patient safety;Patient-Centered Care;Patients;peer support;Performance;Physicians;Play;predictive modeling;Prevention;Primary Care Physician;Productivity;programs;Reporting;Research;Research Infrastructure;Research Personnel;Role;Safety;Scientist;screening;Services;square foot;suicidal risk;Suicide prevention;System;Technology;theories;tool;Training;United States National Institutes of Health;Veterans;Vision;Wages

PROJECT_TITLE: Ann Arbor COIN Renewal Application


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: The Center for Healthcare Organization and Implementation Research has a mission to conduct organizationally-partnered, and Veteran-partnered research in order to develop, implement, and evaluate evidence-based and innovative practices that improve Veterans Health Administration (VA) healthcare. Our priority goals are: (1) to advance the field of HSR by sustaining, developing, and growing our existing, scientific focus areas, and growing our evolving and emerging scientific areas; (2) to enrich VA's cadre of world-class HSR investigators, by supporting training and education across the career spectrum; and (3) to grow and support innovation in order to maintain VA at the cutting edge of HSR and adapt to meet VA's ever- changing needs.

PI_NAMEs: BOKHOUR, BARBARA G.;GIFFORD, ALLEN L (contact)

PROJECT_TERMS: Address;Adherence;Adverse event;Area;Behavioral;Boston;care coordination;care systems;career;career development;Caring;Collaborations;Communication;community living;connected care;Decision Making;Development;Diffusion of Innovation;Educational process of instructing;Elderly;Elements;Environment;evidence base;Face;Future;Geriatrics;Germination;Goals;health care service organization;Health Service Area;Health Services Administration;Health Services Research;Healthcare;Homelessness;implementation research;improved;Incubators;innovation;International;Justice;K-Series Research Career Programs;Long-Term Care;Long-Term Care for Elderly;Measurement;Measures;Medication Management;Mental Health;Mentors;Mission;Modeling;Operative Surgical Procedures;Outcome;patient oriented;Patient Outcomes Assessments;patient safety;Patient-Centered Care;Patients;Pharmaceutical Preparations;Pharmacologic Substance;pharmacy benefit;Postdoctoral Fellow;Primary Care;Process;programs;Recovery;Research;Research Personnel;Resources;Safety;Scientist;Standardization;success;Suicide prevention;Surgeon;System;team-based care;Technology;Testing;Training and Education;Training Support;Transition Career Development Award (K22);Universities;Veterans;Veterans Health Administration;Vulnerable Populations;whole health;Work


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: The VA HSR&D Center for the Study of Healthcare Innovation, Implementation & Policy (CSHIIP) has had a fundamental role in the ongoing transformation of VA health care, through critical examination of multilevel determinants of variations in VA care, development and testing of innovative healthcare delivery models that improve the effectiveness and value of VA care, and impact on VA practice and policy through implementation and spread of evidence-based practice. Our work is anchored in a longstanding history of high-impact research through career development, support, and engagement of a multidisciplinary cadre of investigators, leveraging extensive partnerships that have infused our mission, vision, and values with a deep understanding of VA priorities. These partnerships and priorities have guided our strategic planning, enabling us to build a portfolio of highly responsive research in key focused (primary care, women’s health, high-risk/high-need groups) and emerging areas (complementary/integrative health, specialty care, and emergency management).

PI_NAMEs: YANO, ELIZABETH M (contact)

PROJECT_TERMS: Academy;Acceleration;acute care;Adoption;Affect;Area;care coordination;care delivery;career development;Caring;Collaborations;Communication;Complementary Health;Comprehensive Health Care;Development;Disasters;Discipline of Nursing;Dissemination and Implementation;Doctor of Philosophy;Effectiveness;Emergency Situation;Employee;Employee Engagement;Evaluation;evidence base;Evidence based practice;experience;Funding;Gender;Goals;harassment;Health;Health system;Healthcare;high risk;Home;Homelessness;Homogeneously Staining Region;implementation science;improved;innovation;Integrative Medicine;Intervention;Leadership;Los Angeles;Medical;Medical center;medical schools;medical specialties;Medicine;Mentors;Methodology;Methods;Mission;Modeling;multidisciplinary;Neighborhoods;novel;older adult;operation;Outcome;Paper;Patients;Policies;Primary Care;Provider;provider behavior;Public Health;Publishing;Quality of Care;Readiness;Recording of previous events;recruit;Research;Research Personnel;resilience;Role;Safety;scale up;Scientific Advances and Accomplishments;Service delivery model;Services;severe mental illness;Site;Strategic Planning;substance use;System;Testing;tool;Training;United States Agency for Healthcare Research and Quality;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Variant;Veterans;Vision;whole health;Woman;Women's Health;Women's Health Services;Work;Workplace


ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: The Informatics, Decision-Enhancement, and Analytic Sciences (IDEAS) Center of Innovation will conduct research to advance scientific discovery, implement novel interventions, promote cross-center collaboration, increase research capacity, and engage operational partners to improve Veteran health. Our research will focus on the public health threat of antibiotic resistance, on mitigating health risks in Veterans during periods of vulnerability, and on improving medication safety as the Department of Veterans Affairs (VA) transitions to a new electronic health record. Across all of these areas, we study methods to promote the adoption of research findings into clinical practice. In the process, we train the next generation of outstanding VA health services researchers. Veteran and stakeholder engagement is a topmost priority for our Center. All of our research is highly collaborative and integrated with clinical programs.

PI_NAMEs: SAMORE, MATTHEW H (contact)

PROJECT_TERMS: addiction;Adoption;adverse outcome;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Area;biomedical informatics;Caring;Cities;Clinical;Clinical Investigator;clinical practice;Cognitive;Collaborations;Community Healthcare;Coupled;Data;Decision Making;Decision Support Systems;design;Discipline;Electronic Health Record;Ensure;Environment;Event;Goals;Guidelines;hazard;Health;health care delivery;health information technology;Health Services;Health Services Research;Health system;Healthcare;Healthcare Systems;healthcare-associated infections;implementation science;improved;Infection prevention;Informatics;Infrastructure;innovation;Intervention;Knowledge;Leadership;Learning;Link;medication safety;Medicine;Mental Health;Methodology;Methods;Military Personnel;Modernization;Natural Language Processing;Nature;next generation;novel;Overdose;patient safety;Pharmacoepidemiology;Population;prediction algorithm;Process;programs;Public Health;Qualitative Research;recruit;Research;Research Activity;Research Personnel;Risk;Rural Health;Safety;Science;Scientific Advances and Accomplishments;simulation;Sodium Chloride;Source;stakeholder perspectives;Statistical Models;success;suicidal;System;Therapeutic;tool;Training;Translational Research;Traumatic Brain Injury;Trust;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Vision;Visualization

PROJECT_TITLE: IDEAS 3.0


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE PUBLIC HEALTH RELEVANCE: Defects in cranial neural crest development lead to a variety of craniofacial diseases and malformations affecting the face, e.g. Treacher Collins syndrome, DiGeorge syndrome, and cleft palate to name a few. In this project, I will investigate the regulation and mechanism of function of the secreted protein Draxin, which will significantly enhance our understanding of the regulation of cranial neural crest delamination and migration, providing new scientific avenues for translational research applications in the treatment of craniofacial defects.

PI_NAMEs: HUTCHINS, ERICA  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Affect;antagonist;beta catenin;Binding;Biochemistry;Bioinformatics;Biological Assay;Cadherins;Cartilage;Cell Adhesion;Cell Adhesion Molecules;Cell-Cell Adhesion;Central Nervous System;Cephalic;Chick;ChIP-seq;Cleft Palate;Co-Immunoprecipitations;craniofacial;Craniofacial Abnormalities;craniofacial structure;Data;Defect;Development;DiGeorge Syndrome;Disease;Down-Regulation;E-Cadherin;Embryo;Embryology;epithelial to mesenchymal transition;Etiology;Event;experimental study;Extracellular Matrix Proteins;Face;Fluorescence Resonance Energy Transfer;Gelatinase B;Gene Expression;Genomic Segment;Goals;Head;Image;Immunoprecipitation;In Situ Hybridization;in vivo;Integrins;knock-down;Laminin;laminin alpha5;Lead;Ligation;Light;Maintenance;malformation;Mandibulofacial Dysostosis;Mediating;Mentors;Messenger RNA;Microscopy;migration;Molecular;mRNA Expression;Mutate;Mutation;N-Cadherin;Names;Neural Crest;Neural Crest Cell;neural plate;Neural tube;neuroepithelium;overexpression;Pathway interactions;Phase;Play;Population;Post-Transcriptional Regulation;posttranscriptional;Protein Secretion;Proteins;public health relevance;receptor;Regulation;Reporter;Research;RNA;RNA-Binding Proteins;Role;sensor;Site;Skeleton;Snails;spatiotemporal;stem cell population;Tail;Techniques;Time;Translational Research;Untranslated Regions;Up-Regulation;WNT Signaling Pathway

PROJECT_TITLE: Characterization of the roles and regulation of Draxin in cranial neural crest


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: Nashville

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Hospital acquired bacterial and fungal infections are a major threat to critically ill patients. Innate immunocytes retain memory of prior pathogen exposure, which primes them to elicit a robust antimicrobial response upon re- exposure to additional pathogens. The goal of this project is to advance our understanding of innate immunological memory at the molecular level so that it can be harnessed to protect against hospital acquired bacterial and fungal infections.

PI_NAMEs: MCBRIDE, MARGARET ANN (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Aconitic Acid;Affect;Agonist;Antigens;antimicrobial;Antimicrobial Resistance;Attenuated;Bacteria;Bacterial Infections;Biogenesis;Body Temperature;Bone Marrow;Cells;Cessation of life;Citric Acid Cycle;Clinical;combat;Complex;Critical Illness;cytokine;Data;Disease;Electron Transport;Enzymes;experimental study;Exposure to;first responder;Generations;Genes;Glycolysis;Goals;Gram-Negative Bacterial Infections;Hospitals;Host resistance;Immunity;Immunologic Memory;improved;In Vitro;in vivo;Infection;infection management;Infection prevention;Injury to Kidney;innate immune mechanisms;Innate Immune System;insight;Investigation;knock-down;Knock-out;Knockout Mice;Knowledge;Laboratories;Ligands;Light;Lipid A;liver injury;Lysosomes;Macrophage;Measures;Mediating;Medical Technology;Memory;memory retention;Metabolic;Metabolism;Microbe;microbial;Mitochondria;Modeling;Molecular;Mycoses;Natural Immunity;Nosocomial Infections;Oxidative Phosphorylation;pathogen;pathogen exposure;Pathway interactions;patient population;Patients;Phagocytosis;Phenotype;Physicians;Play;Production;Property;Prophylactic treatment;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Publishing;Reactive Oxygen Species;Recording of previous events;recruit;Research;Resistance to infection;Respiratory Burst;response;Role;Scientist;Small Interfering RNA;Staphylococcus aureus;Staphylococcus aureus infection;Succinate Dehydrogenase;Testing;TLR4 gene;Training;Translations;United States;Vaccine Adjuvant;Vaccines;Vacuole;Vulnerable Populations

PROJECT_TITLE: The role of Immunoresponsive gene 1 in protection against infection


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Antibody-Secreting Cells (ASC), including Plasma Cells, are the cells responsible for the production of protective antibodies in response to infections and vaccinations. However, rogue ASC that produce undesired antibodies against human tissues are also responsible for myriad antibody-mediated diseases including autoimmune diseases, allergy and transplant rejection. In this project, we will study the different types of ASC that provide protection and induce disease to understand their nature and regulatory programs. The information gained will improve our ability to design safer and more effective treatments multiple antibody-mediated diseases and modulatory strategies to optimize protective vaccine responses.

PI_NAMEs: SANZ, IGNACIO E. (contact)

PROGRAM_OFFICER_NAME: FERGUSON, STACY E

PROJECT_TERMS: Acute;Allergic Reaction;Animals;Antibodies;Antigens;Area;arm;Autoimmune Diseases;Autoimmune Responses;autoreactivity;B-Lymphocytes;base;Bioinformatics;Biological Response Modifier Therapy;Bone Marrow;Cell Aging;Cell Compartmentation;Cell Differentiation process;Cell Maturation;Cell Physiology;Cell Survival;Cells;Chromatin;Complementary DNA;Computer Analysis;COVID-19 pandemic;CRISPR/Cas technology;Data Set;data sharing;design;Development;Disease;DNA Methylation;effective therapy;Endowment;Ensure;Epigenetic Process;epigenetic regulation;epigenomics;EZH2 gene;Foundations;Generations;Genetic Transcription;Genome engineering;Goals;Graft Rejection;Health;Heme;Heterogeneity;histone modification;Human;human tissue;Hypersensitivity;immune function;Immune system;immunogenic;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunoglobulin-Secreting Cells;improved;Infection;Information Dissemination;Institution;Investigation;Iron;Laboratory Personnel;Libraries;Longevity;Mediating;Memory;Memory B-Lymphocyte;Metabolic;Metabolism;methylation pattern;Molecular;Nature;overexpression;Pathogenicity;Pathway interactions;Plasma Cells;Plasmablast;Population;Preparation;Process;Production;programs;Regulation;Research Personnel;response;Role;Safety;Serology;SIRT1 gene;Systemic Lupus Erythematosus;Transcriptional Regulation;transcriptome;Vaccination;vaccine response;Work

PROJECT_TITLE: Plasma Cells in Health and Disease


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Opioids;Prevention;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: Project Narrative The criminalization of certain drugs in the United States shapes access to preventive and harm reduction services and drives stigma for people who use drugs. Through a supplement for the Harm Reduction Research Network Coordination Center, we propose to establish a roadmap for future research to understand the intersection between harm reduction and the criminal legal systems that limit access to critical services for people who use drugs and enhance understanding of the effectiveness and associated implementation facilitators of and barriers to harm reduction strategies to address the ongoing opioid crisis.

PI_NAMEs: CANCE, JESSICA DUNCAN (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Address;Administrative Supplement;Affect;Area;Communication;Communities;Consensus;Consultations;Continuity of Patient Care;Data;Data Collection;data harmonization;Drug user;Effectiveness;Effectiveness of Interventions;Environment;evidence base;Evidence based practice;Exclusion;experience;Expert Systems;Funding;Future;Harm Reduction;healing;Health;implementation facilitators;improved outcome;Individual;innovation;Intercept;International;Intervention;Investments;Justice;Knowledge;Lead;Legal;Legal system;Lived experience;Manuscripts;Measurement;Measures;Methodology;Metric System;Modeling;Opioid;opioid epidemic;opioid overdose;opioid use disorder;Overdose;Overdose reduction;Paper;parent grant;parent project;Persons;Pharmaceutical Preparations;Policies;prevent;Preventive;Process;Public Health;public health research;Publishing;Reduce health disparities;Reporting;Research;research and development;Research Peer Review;Research Personnel;Research Priority;resource guides;Risk;Role;Scientist;Services;Shapes;Site;social stigma;structural health determinants;substance use;Substance Use Disorder;success;symposium;systematic review;Testing;Translations;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: RTI HEAL Harm Reduction Network Coordination Center


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Stroke

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Language impairments that result from right hemisphere brain damage (RHD) are poorly understood and the parent K23 award focuses on the nature of RHD communication differences and their neuroanatomic correlates. Funds from this administrative supplement will support additional study staff to complete data analyses through the supplement period. Thus, this supplemental support will ensure the timely completion of the K23 parent project and promote the continuity of PI Dr. Jamila Minga’s plans to build an independent research program developing sensitive diagnostic tools and therapeutic approaches for RHD survivors.

PI_NAMEs: MINGA, JAMILA  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Administrative Supplement;Adult;American;Behavior;Brain Injuries;Brain region;caregiving;Characteristics;Chronic Phase;Clinical;Code;cognitive process;Communication;Communication difficulty;Communication impairment;Comprehension;cortex mapping;Data;Data Analyses;Data Analytics;Data Collection;Development;Diagnosis;Diagnostic;diagnostic tool;Disease;Doctor of Philosophy;Education;Emergency Situation;Emotional;Employment;Ensure;Fostering;Funding;Future;Genetic Transcription;Goals;Health;hemisphere damage;Image;Impairment;improved;indexing;Individual;information gathering;Knowledge;Language;language impairment;Left;Lesion;Long-Term Care for Elderly;Magnetic Resonance Imaging;Maps;Measures;Mentored Patient-Oriented Research Career Development Award;Mentorship;Modeling;Monitor;MRI Scans;Nature;Neuroanatomy;neuroimaging;Outcome;Output;parent project;Parents;Pathologist;Patients;Pattern;personalized diagnostics;Procedures;Process;Production;Productivity;programs;Quality of life;Recovery;Research;Research Project Grants;right hemisphere brain damage;Risk;Sampling;Social Interaction;Speech;Stroke;student training;Survivors;Symptoms;syntax;theories;Therapeutic;therapy development;Training;Training Support;undergraduate student;Work;X-Ray Computed Tomography

PROJECT_TITLE: Neuroanatomic Correlates of Language Production Characteristics After Right Hemisphere Stroke


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Emergency Care;Hematology;Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_NAME: BAEBIES, INC.

PHR: PROJECT NARRATIVE Trauma is a leading cause of death worldwide, with hemorrhage constituting the most common cause of preventable death after injury. One third of hemorrhaging patients develop trauma induced coagulopathy, characterized by abnormal coagulation and inflammation, and require urgent transfusion to decrease the likelihood of organ failure and mortality. Conventional coagulation tests are informative, but most are not adequate for acute hemorrhage control due to long result turnaround times (40 minutes). We will develop a trauma coagulation panel and detection system for four common analytes that will provide clinically actionable data in under 10 minutes at the point-of-care to inform transfusion requirements, reduce iatrogenic blood loss from recurrent coagulation monitoring, and improve clinical workflow in busy trauma settings.

PI_NAMEs: PAMULA, VAMSEE K. (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Accident and Emergency department;Activated Partial Thromboplastin Time measurement;Acute;Address;Adult;American;Anemia;assay development;Automation;Award;Biological Assay;Biological Markers;Blood;Blood Coagulation Disorders;Blood Coagulation Factor;Blood Platelets;blood product;Blood Transfusion;Blood Volume;Businesses;Cause of Death;cellular imaging;Cessation of life;Clinical;Clinical Chemistry;clinically actionable;Coagulation Process;Complex;Data;design;detection platform;Development;Devices;Diagnosis;Diagnostic;digital;Disparate;Drops;Endothelium;Engineering;Ensure;Evaluation;experience;feasibility testing;Fibrinogen;Funding;Generations;Goals;Guidelines;Hematologist;Hemorrhage;Hemostatic function;Hour;Iatrogenesis;imaging capabilities;immune system function;improved;Inflammation;Injury;innovation;innovative technologies;instrument;International Normalized Ratio;Journals;Laboratories;Left;Legal patent;Manuscripts;Marketing;Measurement;Measures;Methods;microfluidic technology;Microfluidics;military trauma;Monitor;Monitoring for Recurrence;Morbidity - disease rate;mortality;multidisciplinary;multiplex assay;Operating Rooms;operation;Operative Surgical Procedures;Optics;Organ failure;Patient-Focused Outcomes;Patients;pediatric patients;Performance;Perioperative;Phase;Plasma;Platelet Count measurement;point of care;point of care testing;portability;post-trauma;Postoperative Period;preventable death;Procedures;Prothrombin time assay;Protocols documentation;prototype;Publishing;rapid detection;Recommendation;Recurrence;Research;Risk;risk minimization;Running;Sampling;Scientist;Shock;Small Business Innovation Research Grant;System;Technology;Testing;Therapeutic;Time;Training;Transfusion;Trauma;trauma induced coagulopathy;Trauma patient;Traumatic Hemorrhage;Triage;Update;viscoelasticity;Whole Blood

PROJECT_TITLE: A Near-Patient, Low Blood Volume Platform for Rapid Comprehensive Evaluation of Coagulation in Trauma Patients


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: San Diego

ORG_NAME: ONCTERNAL THERAPEUTICS, INC.

PHR: Narrative: Kennedy’s disease is a progressive genetic neurodegenerative disease caused by an abnormal androgen receptor (AR) protein. There is currently no effective treatment available to slow, stop, or reverse the disease. Based on promising preclinical results obtained under funded Phase 1 STTR and Phase 2 SBIR grants, Oncternal proposes to further perform the scope of our Phase 2 SBIR using this technical assistance to include bioanalysis method development to begin readiness for GLP in vivo toxicology studies. This method development will continue the development studies with our androgen receptor antagonist and degrader ONCT-505, to destroy the AR protein as a potential therapeutic for Kennedy’s disease.

PI_NAMEs: KRISHNAN, RAJESH  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: advanced prostate cancer;Androgen Receptor;androgen sensitive;androgenic;Animal Model;antagonist;Award;Binding;Biological Availability;Castration;Clinical;cross reactivity;Data;Development;Disease;Dose;drug candidate;drug development;Drug Kinetics;effective therapy;Evaluation;experimental study;Funding;Genetic;Grant;In Vitro;in vivo;Investigational Drugs;Investigational New Drug Application;Kennedy Syndrome;Knock-out;manufacture;manufacturing process;Medical;Metabolic;method development;Methods;motor neuron degeneration;multicatalytic endopeptidase complex;mutant;N-terminal;Neurodegenerative Disorders;Neurons;neurotoxic;novel therapeutics;Oral;Pathway interactions;patient - derived stem cells;Patients;Pharmaceutical Preparations;pharmacologic;Phase;phase I trial;polyglutamine;pre-clinical;Pre-Clinical Model;preclinical development;preclinical efficacy;Property;protein degradation;Proteins;Readiness;receptor;Receptor Activation;Research;Rodent;Safety;Signal Transduction;skeletal muscle wasting;Small Business Innovation Research Grant;Small Business Technology Transfer Research;small molecule therapeutics;Spinobulbar Muscular Atrophy;stem cell differentiation;Testosterone;Therapeutic;Therapeutic Agents;Toxic effect;Toxicokinetics;Toxicology;Ubiquitin;Validation

PROJECT_TITLE: Preclinical development of ONCT-505, an Androgen Receptor Antagonist and Degrader, as New Potential Therapeutic for Kennedy's Disease


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Biotechnology;Hematology;Immunization;Immunotherapy;Lymphatic Research;Physical Injury - Accidents and Adverse Effects;Prevention;Regenerative Medicine;Vaccine Related

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Narrative Exposure to high doses of ionizing radiation within a relatively short period of time can cause acute radiation syndrome (ARS), a severe form of radiation injury that can occur at events such as a “dirty bomb” terrorist attack or nuclear power plant leakage. ARS survivors may develop delayed effects of radiation exposure (DEARE) and there are no therapeutic agents available to prevent or alleviate DEARE. Our proposal will define the functional immuno-radiobiology of the regenerative immune system after whole body irradiation in mice. Since the tissue targets of radiation injury are well studied, we can also correlate whether T-cell immune senescence and dysfunction of myeloid population contributes to DEARE. These studies will provide a blueprint for developing optimized immuno-conditioning regimens for immunization protocols in radiation survivors that can be extended to immunocompromised and elderly population.

PI_NAMEs: GUHA, CHANDAN  (contact)

PROGRAM_OFFICER_NAME: WINTERS, THOMAS A

PROJECT_TERMS: Acceleration;Acute;Agonist;Anemia;Animals;Antibody titer measurement;Antigen Presentation;Antigen-Presenting Cells;Antigens;atomic bomb;Autophagocytosis;B-Lymphocytes;Bacteremia;Biological Assay;Bone Marrow;Bone Regeneration;CD28 gene;CD3 Antigens;CD8-Positive T-Lymphocytes;cell regeneration;Cellular Immunity;Clinical;conditioning;CSF3 gene;CXCL10 gene;CXCR3 gene;cytokine;Defect;dirty bomb;Dose;Effector Cell;Elderly;Event;exhaust;exhaustion;Exhibits;Exposure to;Extravasation;Failure;FDA approved;FLT3 ligand;Functional disorder;functional restoration;ghrelin;Granulocyte-Macrophage Colony-Stimulating Factor;Helper-Inducer T-Lymphocyte;Hematopoietic Cell Growth Factors;Homeostasis;IL17 gene;IL7 gene;Immune;Immune system;Immune System Diseases;Immunization;Immunobiology;Immunocompromised Host;Immunoglobulin G;Immunoglobulin M;Immunologics;Immunology procedure;Immunophenotyping;immunosenescence;Impairment;Inflammation;Inflammatory;inhibition of autophagy;Injury;Interferon Type II;Interleukin-2;Interleukin-6;intestinal epithelium;Intestines;Ionizing radiation;Japan;Lethal Dose 50;Listeria;Longitudinal Studies;Lung;lymph nodes;Lymphocyte;Lymphocyte Count;Lymphocyte Depletion;Lymphocyte Function;lymphoid organ;Lymphopenia;Marrow;Measures;Mediating;Memory;Metformin;mimetics;mitochondrial dysfunction;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Molecular Chaperones;MPL gene;mucosa-associated lymphoid tissue;Multiple Organ Failure;Mus;Myelogenous;Natural regeneration;Neutropenia;neutrophil;novel;Nuclear Power Plants;Outcome;Outcome Measure;Ovalbumin;Oxygen Consumption;p38 Mitogen Activated Protein Kinase;Peptides;peripheral lymphoid organ;Peritoneal;Phagocytosis;Phase;Phenotype;Population;prevent;Production;programmed cell death protein 1;programs;Proliferating;Proteins;Protocols documentation;Radiation;radiation countermeasure;radiation effect;Radiation exposure;Radiation Injuries;radiation mitigation;radiation mitigator;Radiation Toxicity;Radio;Radiobiology;Recombinants;regenerative;Regimen;Residual state;response;RNA vaccine;Roentgen Rays;SARS-CoV-2 spike protein;senescence;senescence associated secretory phenotype;Septic Shock;Serum;Spleen;subcutaneous;Survivors;Syndrome;systemic inflammatory response;T cell receptor repertoire sequencing;T-Cell Proliferation;T-Lymphocyte;Terrorism;Therapeutic Agents;Thrombocytopenia;Thrombopoietin;Thymus Gland;Time;Tissues;TNF gene;transcriptomics;Transgenic Mice;Vaccination;Whole-Body Irradiation

PROJECT_TITLE: Regeneration of the Immune System after Radiation Exposure


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Diabetes;Neurodegenerative;Nutrition;Obesity

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE There is a pressing need for new therapies for obesity and type 2 diabetes, either alone or to complement current treatments. This proposal will establish the molecular mechanisms underlying control of glucose homeostasis by a newly discovered adipokine. Our project is anticipated to lead to a better understanding of how glucose is regulated by insulin-independent pathways, ultimately leading to facilitate the translation to human clinical applications.

PI_NAMEs: SVENSSON, KATRIN JENNIFER (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Address;Adipocytes;adipokines;Adipose tissue;Animals;Biochemical;Biological;Blood Glucose;blood glucose regulation;Cardiovascular Diseases;Cell Surface Receptors;Chronic;clinical application;combat;Complement;Data;Diabetes Mellitus;diabetic;Endocrine;Energy Metabolism;Engineering;euglycemia;expression vector;Fatty acid glycerol esters;feeding;Genetic;Glucose;glucose metabolism;Glucose tolerance test;glucose uptake;Goals;High Fat Diet;Homeostasis;Hormonal;hormonal signals;Hormones;Human;improved;In Vitro;in vivo;innovation;insight;Insulin;Insulin Receptor;Insulin Resistance;insulin sensitivity;Insulin Signaling Pathway;Knockout Mice;Liver;Maintenance;Mammals;Mediating;Mediator;Medical;Metabolic;Metabolic dysfunction;metabolic phenotype;Methods;Molecular;Monitor;multidisciplinary;Mus;Muscle;Muscle Fibers;mutant;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;novel therapeutics;obesity treatment;Outcome;overexpression;Pathway interactions;pharmacologic;Pharmacological Treatment;Physical activity;Physiological;Physiology;PI3K/AKT;Play;Polypeptide Hormones;Proteins;Proteomics;Public Health;receptor;Receptor Protein-Tyrosine Kinases;Recombinant Proteins;Recombinants;Reproducibility;Role;Signal Pathway;Signal Transduction;Skeletal Muscle;Surface;Therapeutic;Therapeutic Agents;therapeutic target;Tissues;tool;translation to humans;translational potential;Weight Gain

PROJECT_TITLE: Control of glucose homeostasis through the insulin-independent Isthmin pathway

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition;Obesity

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PI_NAMEs: KIM, YOUNG-BUM  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Affect;Amygdaloid structure;Anorexia;Biochemical;Body Weight;Cardiovascular Diseases;Chronic Disease;Data;designer receptors exclusively activated by designer drugs;Desire for food;Eating;energy balance;Energy Metabolism;experimental study;Fatty acid glycerol esters;Fatty Liver;feeding;Genetic Engineering;Goals;GTP-Binding Proteins;Guanosine Triphosphate Phosphohydrolases;Homeostasis;Human;Hyperphagia;Hypothalamic structure;Impairment;inducible Cre;insight;insulin sensitivity;Knowledge;Link;Malignant Neoplasms;Mediating;Mediator;Melanocortin 4 Receptor;Metabolic;Metabolic Diseases;metabolic phenotype;Molecular;Morbid Obesity;mouse model;MSH receptor;Mus;Mutant Strains Mice;Mutation;neuron development;Neurons;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity development;obesity treatment;overexpression;Pakistan;Pathogenesis;Phosphotransferases;Physiological;Population;Recombinant adeno-associated virus (rAAV);Regulation;response;rho;Rho-associated kinase;Risk Factors;Signal Pathway;Signal Transduction;System;Techniques;Tissue Engineering;Transgenic Mice;Ubiquitin-Conjugating Enzymes;Ubiquitination;Variant;Weight Gain;α-Melanocyte stimulating hormone

PROJECT_TITLE: Rho-kinase signaling in energy balance

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: MILWAUKEE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative: The proper temporal and spatial regulation of chromatin is key in human development and health, and dysregulation leads to diseases such as diabetes, cancer, heart disease, and developmental, neurological, and immunological disorders. The proposed research project will further our understanding of the molecular mechanisms that alter the structure and accessibility of chromatin. These studies will contribute to fundamental knowledge about mechanisms of gene regulation and how dysregulation leads to disease states.

PI_NAMEs: MORRISON, EMMA ANTONINA (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acylation;Binding;biophysical techniques;Centromere;Chemicals;Chromatin;Chromatin Structure;Chromosomal Stability;Complex;Core Protein;developmental disease;Diabetes Mellitus;Disease;DNA;Epigenetic Process;Gene Expression;Gene Expression Regulation;Genetic;Goals;Health;Heart Diseases;histone modification;Histones;Human Development;human disease;Immune System Diseases;Knowledge;Laboratories;Language;Link;Lysine;Malignant Neoplasms;Metabolic;Metabolic Diseases;Mitosis;Molecular;Molecular Conformation;Nervous System Disorder;NMR Spectroscopy;Nucleosomes;Phase;Post-Translational Protein Processing;Regulation;Research Project Grants;Role;Structure;System;Tail;Translating;Variant

PROJECT_TITLE: The role of histone tails in chromatin structure and gene regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: East Hanover

ORG_NAME: KESSLER FOUNDATION, INC.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE We propose a small scale pilot clinical trial to evaluate technology specific improvements for the use of spinal cord epidural stimulation to function in individuals with spinal cord injury. We will develop technology that will interact with currently available stimulators, to facilitate the implementation and integration of training programs for the recovery of locomotion and bladder function in individuals with acute spinal cord injury and promote safe long-term use of the technology in the home and community. This study will start addressing some technology gaps by developing a flexible communication platform specific for spinal cord injury.

PI_NAMEs: ANGELI, CLAUDIA  (contact);BOAKYE, MAXWELL

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Autonomic Dysreflexia;Autonomic nervous system;Awareness;Bladder;Blood Pressure;blood pressure control;Blood Pressure Monitors;blood pressure regulation;Cardiovascular system;Catheterization;Chronic;Chronic Phase;Clinical Trials;Communication;Communities;Data;design;Development;Devices;Diastolic blood pressure;Educational Intervention;Evaluation;experience;Feedback;flexibility;Heart Rate;Home;Impairment;Implant;implementation facilitation;improved;Incidence;Individual;Injury;Intestines;intimate behavior;Laboratories;learning algorithm;Locomotion;locomotor control;locomotor tasks;Locomotor training;Manuals;Measures;Monitor;Motor;motor function recovery;Movement;neural circuit;neuroregulation;normotensive;Participant;Patients;Persons;Phase;Physiological;Positioning Attribute;prediction algorithm;prevent;Publishing;Quality of life;Rain;Randomized;Recovery;Regulation;Reporting;sensor;sensory system;Series;Spinal Cord;Spinal cord injury;Symptoms;System;Systolic Pressure;Technology;Testing;therapeutic evaluation;Time;tool;Training;Training Programs;treadmill;treatment effect;United States;Walking;wireless communication;wireless sensor

PROJECT_TITLE: Inter-System Closed-Loop Control of Locomotor and Bladder Function in Individuals with Acute Spinal Cord Injury


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative: We will use invasive electrical stimulation in neurosurgical patient volunteers to manipulate phrase-structure building neural activity in language areas of the brain while subjects are trying to comprehend a sentence. By observing the resulting effect on behavior and neural activity recorded elsewhere in the brain, we hope to better understand how the brain comprehends grammatical relations in sentences, and use this to develop better treatments for language disorder patients who have grammatical difficulties.

PI_NAMEs: NELSON, MATTHEW JOHN (contact)

PROJECT_TITLE: Neurophysiological mechanisms of language comprehension


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioids;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Opioid drug abuse is associated with worsening of neurocognitive deficits and other neurodegenerative effects seen with HIV infection. This grant proposes to use two in vivo models to examine the complex interplay of opiate-HIV-antiretroviral drug exposure on the central accumulation of drugs (antiretrovirals and morphine), blood-brain barrier function, and neuroimmune function in these mice. Gaining a better understanding of this dynamic interplay, with specific focus on antiretroviral brain concentrations, will improve the current therapeutic approaches for the opiate-using HIV population.

PI_NAMEs: MCRAE, MARY PEACE  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: ABCB1 gene;ABCG2 gene;Amantadine;Animal Model;Anti-Retroviral Agents;antiretroviral therapy;arm;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood damage;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;Brain region;Carrier Proteins;carvedilol;Cells;Cognitive;Cognitive deficits;Complex;cytokine;Dantrolene;Data;Drug Controls;drug efficacy;Drug Exposure;drug metabolism;Drug toxicity;Drug Transport;Event;Feedback;Glial Fibrillary Acidic Protein;Glucuronides;Goals;Grant;HIV;HIV anti-retroviral;HIV Infections;HIV-1;human model;Immune;immune cell infiltrate;Immunofluorescence Immunologic;Impaired cognition;Impairment;improved;in vivo;in vivo Model;Individual;Infection;Infiltration;Inflammation;Inflammatory;inhibitor;Knowledge;Macrophage;mass spectrometric imaging;Measures;Mediating;Metformin;migration;Modeling;monocyte;Morphine;motor deficit;mouse model;Mus;Nerve Degeneration;neuroAIDS;neurobehavioral;Neurocognitive;Neurocognitive Deficit;Neuroimmune;neuroinflammation;neuropathology;neurotoxic;Opioid;opioid abuse;opioid exposure;opioid use;Outcome;Pathogenesis;patients who use opioids;Penetration;Permeability;Pharmaceutical Preparations;Population;Production;promoter;protein expression;Quinidine;recruit;regional difference;Reporting;RNA Interference;Role;Signal Transduction;targeted treatment;tat Protein;Therapeutic;therapeutic development;Time;trafficking;Transgenic Mice;Transgenic Organisms;Treatment Efficacy;Viral Proteins;Western Blotting;Work

PROJECT_TITLE: Opioid- and HIV-mediated effects on the integrity of the blood-brain barrier, on immune cell recruitment, and on antiretroviral penetration into the brain

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_NAME: IBIS REPRODUCTIVE HEALTH

PHR: PUBLIC HEALTH RELEVANCE/PROJECT NARRATIVE Population-level data on the sexual and reproductive health (SRH) needs and experiences of transgender, nonbinary, and intersex (TNBI) people in the U.S. are virtually non-existent. To further the cross-cutting goal identified by NICHD’s Strategic Plan 2020--of addressing health disparities for sexual and gender minorities-- this study will collect rigorous, foundational, epidemiological data on SRH risk factors and outcomes among a large, diverse sample of TNBI people from across the United States; data that are essential to designing effective public health interventions informing evidence-based healthcare, and improving health outcomes. Further, this study will test and evaluate innovations in study design and survey methodology that will improve recruitment, retention, and data quality in studies of marginalized populations across disciplines.

PI_NAMEs: MOSESON LIDOW, HEIDI SERENE (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;Address;Adopted;adverse outcome;Anatomy;arm;Birth;Caring;cis-female;cisgender;clinical care;Color;Communities;Contraceptive Agents;Contraceptive Usage;Control Groups;cost;Data;Data Collection;Data Element;data quality;design;Discipline;Disparity;Dropout;Eligibility Determination;Enrollment;epidemiologic data;Equipment and supply inventories;evidence base;Exclusion;experience;Fertility;field survey;Funding;Gender;gender affirming care;Gender Identity;gender minority group;Geography;Goals;group intervention;Health;health care service;health data;health disparity;Health Personnel;Healthcare;HIV;improved;improved outcome;Incidence;innovation;Institute of Medicine (U.S.);Intersex;Knowledge;Language;Legal Abortion;LGBT Health;Logic;marginalized population;Measures;Medical;Methodology;Methods;National Institute of Child Health and Human Development;nonbinary;novel;Organ;Outcome;Participant;Patients;Persons;Policies;Population;Population Research;Pregnancy;Pregnancy Outcome;pregnant;prevent;primary outcome;Proliferating;Provider;public health intervention;public health relevance;public health research;Quality of Care;racial diversity;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Reporting;Research;Research Design;Research Methodology;Research Personnel;research study;Research Support;Respondent;response;Risk;Risk Factors;Sampling;Sampling Studies;Scientific Advances and Accomplishments;screening;Screening procedure;sex;Sex Behavior;Sexual and Gender Minorities;sexual and reproductive health;Social Network;Strategic Planning;Survey Methodology;Surveys;Testing;tool;transgender;Underserved Population;unintended pregnancy;United States;United States National Institutes of Health;Universities;virtual;Woman;Youth

PROJECT_TITLE: Advancing novel survey tools to increase participation and improve sexual and reproductive health data quality

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Understanding how cell fates are specified in the embryo is a long standing goal of developmental biology. Here we explore a previously unappreciated epithelial to mesenchymal transition in the posterior endoderm, one of the three germ layers that comprise the early embryo, wherein cells invade the neighboring tailbud mesenchyme and potentially contribute to neuromesodermal fates. Understanding signals that regulate this process, the identity of these cells and their progeny, and their potential to differentiate along a remarkably wide range of lineages may have potentially far reaching implications for the study of induced pluripotency, cell reprogramming, and directed differentiation, as well as the pathogenesis of cancer, which commonly originates in endodermally derived tissues, and propagates via epithelial to mesenchymal transition.

PI_NAMEs: NERURKAR, NANDAN L (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Adult;Atlases;Biochemical;Biophysics;Birds;Brain;cell behavior;cell fate specification;Cell Line;Cell Reprogramming;Cells;Chick Embryo;Complex;Cues;Development;Developmental Biology;directed differentiation;Dorsal;Ectoderm;Ectoderm Cell;Embryo;Embryology;Embryonic Development;Endoderm;Endoderm Cell;epithelial to mesenchymal transition;experimental study;gastrulation;Genes;Germ Layers;Goals;in vivo Model;Invaded;Investigation;Malignant Neoplasms;Maps;Mesenchyme;Mesoderm;Mesoderm Cell;Multipotent Stem Cells;Neural tube;notochord;novel;Organ;Pathogenesis;Pattern;pluripotency;Population;Process;progenitor;programs;prospective;Regulation;Research;segregation;Shapes;Signal Transduction;single-cell RNA sequencing;Source;Specific qualifier value;stem;stem cell population;stem cells;Stereotyping;Surface;Time;Tissues;Totipotent;transcriptomics;Tube;Work

PROJECT_TITLE: Investigation of a neuromesendodermal progenitor population in the posterior avian endoderm

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE Tyrosine phosphatases are important regulators of information transfer in cells and can play causal role in human diseases when mutated and/or dysregulated. The development of effective tyrosine phosphatase-targeted therapies requires a clearer picture of the distinct biological roles of the 100 human tyrosine phosphatases and a deeper understanding of how these proteins are regulated. The research proposed here entails the development of new approaches to study tyrosine phosphatase structure and function, and these methods will help clarify the mechanisms by which tyrosine phosphatase activity contributes to both normal and aberrant cellular processes.

PI_NAMEs: SHAH, NEEL H (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Animals;Area;Biochemical;biochemical tools;Biochemistry;Biological;Biological Process;Biology;Cell Physiology;cell type;Cells;Development;Disease;Disparity;Drug resistance;Drug Targeting;Enzymes;experimental study;Goals;Human;human disease;immune activation;interest;Knowledge;Label;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Methods;Molecular;Mutate;Mutation;mutation screening;novel strategies;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Play;Point Mutation;Post-Translational Protein Processing;preference;Protein Dephosphorylation;Protein Tyrosine Kinase;Protein Tyrosine Phosphatase;Proteins;PTPN11 gene;Regulation;Research;resistance mutation;Role;Signal Transduction;Structure;T-Lymphocyte;targeted cancer therapy;targeted treatment;Techniques;Therapeutic;tool;Tyrosine;Tyrosine Phosphorylation;Work

PROJECT_TITLE: Probing tyrosine phosphatase structure and function


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Project Narrative  The incidence of prostate cancer, the most common malignancy and the second leading cause of cancer- related mortality in men in the United States, increases substantially over 50 years of age and in parallel, the prevalence of hip replacement surgery also increases in that age group. Multiparametric magnetic resonance imaging (mpMRI) plays an important role in the diagnosis and disease management of prostate cancer, however, mpMRI is challenging in men with hip implants due to severe image distortions and signal loss. In this study, we will establish a robust mpMRI using our novel acquisition and reconstruction strategy that can be widely implemented across all MR scanners for better management of prostate cancer patients with hip implants and subsequently improve their quality of life and overall survival.

PI_NAMEs: MADHURANTHAKAM, ANANTH J (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: 3-Dimensional;Address;age group;Age Years;American;Biopsy;Cancer Etiology;Cancer Patient;cancer risk;Classification;Clinical;clinical imaging;clinical translation;Clinical Trials;clinically significant;Cold Therapy;density;Detection;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Disease Management;Echo-Planar Imaging;experience;Focused Ultrasound Therapy;follow-up;Goals;Guidelines;healthy volunteer;high risk men;High-Risk Cancer;Hip region structure;hip replacement arthroplasty;Histopathology;human subject;Image;Implant;improved;in vivo;Incidence;Individual;Information Systems;Lesion;magnetic field;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metals;Methods;Monitor;Morphologic artifacts;mortality;next generation;Noise;novel;Operative Surgical Procedures;Outcome;Patient Care;Patient Monitoring;patient population;Patients;Pelvis;Peripheral;Play;Prevalence;prospective;Prostate;prostate biopsy;prostate cancer risk;prostate lesions;Prostate-Specific Antigen;Prostatectomy;Quality of life;radioligand;Recommendation;reconstruction;Reference Standards;Reporting;research clinical testing;Role;Signal Transduction;targeted treatment;Techniques;treatment planning;ultrasound ablation;United States;Urethra;urologic;Visualization

PROJECT_TITLE: Novel 3D DWI for Detection and Characterization of Prostate Cancer in Men with Pelvic Metal Implants


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Hepatitis;Infectious Diseases;Liver Disease

ORG_CITY: DURHAM

PI_NAMEs: DENNY, THOMAS  (contact)

PROJECT_TERMS: Biological Assay;Biometry;Biostatistical Methods;Clinical Trials;co-infection;Cytomegalovirus;Data;Enrollment;Ensure;Evaluation;Hepatitis B Virus;Hepatitis C virus;HIV;Human Herpesvirus 8;Human Papillomavirus;Infectious Agent;Laboratories;Methodology;Multi-site clinical study;National Institute of Allergy and Infectious Disease;Natural History;pathogen;pathogenic virus;Performance;programs;quality assurance;Quality Control;Reagent;Running;Sampling;Simplexvirus;Standardization;Testing;Time;Viral;virology

PROJECT_TITLE: NIAID VIROLOGY QUALITY ASSURANCE (VQA)


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: The Center of Innovation (COIN) for Veteran-Centered and Value-Driven Care has had outstanding productivity and impact on Veteran healthcare and well-being through the application of the National Academy of Medicine's learning health system. In the past 3 years, our 47 investigators generated ~$47 million in operating revenue, published 583 manuscripts, and led 113 projects across our research, implementation science, operational projects/program evaluations and training programs. Our dual-site Center will continue to address our two focus areas: 1) promote Veteran-centered care to improve patient experiences across VA healthcare and community settings and 2) advanced value-driven care by providing Veterans the highest quality care at the lowest financial burden. Building on our prior success, we will continue to partner with operational leaders and our Veteran Engagement Board to innovate new research, implementation science, and operational programs as well as train the next generation of outstanding research leaders.

PI_NAMEs: AU, DAVID H (contact);HO, P. MICHAEL

PROJECT_TERMS: Academy;Address;Area;Award;care delivery;career development;Caring;clinical care;Colorado;Communities;community setting;Complex;Congresses;Deimplementation;disparity elimination;Evaluation;experience;Faculty;Financial Hardship;Funding;geographic disparity;health care service;health care settings;Health Services;Health Services Accessibility;Health Services Research;Health system;Healthcare;Healthcare Systems;implementation science;improved;improved outcome;innovation;Intervention;Knowledge;Lead;Learning;Manuscripts;Medical center;medical specialties;Medicine;Mental Health Services;Methods;Mission;next generation;novel strategies;Paper;Patient Compliance;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;Patients;Personal Satisfaction;Policies;Postdoctoral Fellow;Primary Care;primary health service;Productivity;Program Evaluation;programs;Provider;Psyche structure;Publishing;Quality of Care;Research;research clinical testing;Research Personnel;Rural Health;Safety;satisfaction;Self Management;Site;socioeconomic disparity;sound;Statutes and Laws;success;Suicide prevention;Training;Training Programs;Translating;United States National Institutes of Health;Universities;Veterans;Washington;Women's Health;Work;Workforce Development

PROJECT_TITLE: Seattle-Denver Center of Innovation for Veteran-Centered and Value-Driven Care


ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: The goal of the Durham Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT) is to enhance the Veterans Health Administration's (VHA) ability to continually improve health care and optimize Veteran wellbeing and independence. ADAPT will lead innovative research on promoting and sustaining healthy lifestyles, improving access through virtual care, and optimizing Veteran function and independence. Working closely with VA and non-VA partners, ADAPT investigators will apply and advance state-of-the-art methods, translate research findings into meaningful practice change, and train the next generation of VA researchers. ADAPT will play a vital role in helping VHA meet the challenges of providing timely, coordinated, consistently high-quality care to more than 9 million Veterans each year.

PI_NAMEs: HASTINGS, SUSAN NICOLE (contact)

PROJECT_TERMS: Acceleration;Address;Area;Behavior;burden of illness;care systems;career development;Caring;Clinical;clinical care;Collaborations;Communities;Data Sources;design;Development;Educational workshop;effectiveness evaluation;Effectiveness of Interventions;Ensure;experience;Face;Family;Fostering;Funding;Goals;Grant;Health behavior;health care availability;health care service organization;Health Services;Health Services Research;Health system;Healthcare;Healthcare Systems;healthy lifestyle;implementation research;Improve Access;improved;Individual;innovation;Lead;Leadership;Life;Long-Term Care;Mentorship;Methods;Modeling;Names;next generation;novel;Observational Study;Personal Satisfaction;Phase;Physicians;Pilot Projects;Play;Policies;Postdoctoral Fellow;Pragmatic clinical trial;Process;Quality of Care;Recording of previous events;Research;research and development;Research Infrastructure;Research Personnel;research study;resilience;Resources;Role;routine practice;Science;social factors;Time;Training;Translating;Translations;Veterans;Veterans Health Administration;virtual healthcare;Work;World Health Organization


ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

ORG_STATE: IL

PHR: The Center of Innovation for Complex Chronic Healthcare (CINCCH) is a HSR&D COIN based at Hines VA Hospital. CINCCH's mission is to conduct research to optimize coordination and contextualization of healthcare delivery and improve outcomes for Veterans with high priority neurologic conditions, disseminate and implement best evidence, and train future researchers. We utilize innovative direct observation methods to collect data that compliments other forms of data to assess quality and patient experiences. CINCCH collaborates with several VA Operations Partners and is affiliated with three universities in the Chicago area. In addition, we have established a Veterans Engagement Panel that provides feedback on grant proposals and dissemination activities. Our COIN's vision is to create the evidence and implement the findings to support and guide VA in providing the best care in the right place at the right time.

PI_NAMEs: WEAVER, FRANCES M. (contact)

PROJECT_TERMS: Address;Antibiotics;Applications Grants;Appointment;Area;Award;bone health;Books;care coordination;career;Caring;Centers for Disease Control and Prevention (U.S.);Chicago;Chronic;Chronic Care;Collaborations;Complex;Data;decubitus ulcer;Disease;Doctor of Medicine;Doctor of Philosophy;experience;Faculty;Feedback;Funding;Future;health care delivery;Health Care Research;Health Services;Healthcare;Homelessness;Homogeneously Staining Region;Hospitals;Illinois;improved;improved outcome;innovation;Institution;instrument;Kidney Diseases;Leadership;Life;Medicare;Mentors;Methods;Mission;Modeling;Modernization;Neurologic;operation;Paper;Patient-Centered Care;Patients;Persons;pharmacy benefit;Physical Medicine;Physical Rehabilitation;programs;Renal dialysis;Research;Research Personnel;Respiratory Tract Infections;Scientist;Services;Source;Spinal cord injury;telehealth;Time;Training;Universities;Veterans;Vision;Weight Gain;Weight maintenance regimen;Work


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: The Center for Access and Delivery Research and Evaluation (CADRE) is seeking to renew its Center of Innovation (COIN) funding to advance research and improve access for Veterans. We aim to build upon our existing expertise, established operational partnerships, and long-term research objectives through prioritizing five overarching goals that align with our focused areas of research and emerging priorities. GOAL 1: Improve access to high quality care for rural Veterans through innovative applications of telehealth in specialty care, community care, and dual use. GOAL 2: Develop and evaluate interventions targeting the multidrug-resistant organism crisis. GOAL 3: Expand efforts in developing innovative health services research in three additional areas: (1) women’s health, (2) epidemic opioid use and substance use disorders, and (3) cardiovascular outcomes. GOAL 4: Continue the Center’s success in supporting mentored career development. GOAL 5: Promote Veteran engagement with recognition that Veterans are experts on Veteran experience.

PI_NAMEs: PERENCEVICH, ELI N (contact)

PROJECT_TERMS: Address;Area;barrier to care;Cardiovascular system;career development;Caring;Centers for Disease Control and Prevention (U.S.);Cities;Communities;Community Healthcare;connected care;design;digital intervention;Endocrinologist;Enrollment;Equity;Evaluation;experience;Face;Fertility;Funding;Goals;health care availability;Health Services Research;Healthcare Systems;Improve Access;improved;innovation;Internet;Intervention;Iowa;Leadership;medical specialties;meetings;Mentors;multi-drug resistant pathogen;operation;opioid epidemic;opioid use;Outcome;pharmacy benefit;Poverty;Prevention;Provider;Publishing;Quality of Care;Recommendation;reproductive;Research;Research Personnel;Research Priority;Resources;Rural;rural area;Rural Health;rural setting;Scientist;Services;Substance Use Disorder;success;telehealth;Universities;Veterans;Women's Health;Women's Health Services

PROJECT_TITLE: Center for Access & Delivery Research and Evaluation (CADRE)


ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: The Houston Health Services Research & Development (HSR&D) Center for Innovations in Quality, Effectiveness and Safety (IQuESt) has been continuously funded by HSR&D since 1990, providing strong scientific leadership and institutional infrastructure dedicated to a model of embedded health system research. We have a nearly 20-year tradition of conducting research in partnership with the health care delivery system and responding to its needs, making us pioneers in the execution of the learning health care system model in VHA. The IQuESt mission, “Improving health and well-being through innovations in health care delivery”, conveys our commitment to transformative and innovative research that is aligned with VHA national priorities. IQuESt is ideally poised to contribute to making care more accessible, safer, and more patient-centered with innovative research, rapid implementation of evidence, novel methodologies, solid partnerships, stakeholder engagement, career development of scientists, and infrastructure to promote the learning health care system in VHA.

PI_NAMEs: PETERSEN, LAURA A (contact)

PROJECT_TERMS: Biological Models;career development;Caring;Dedications;Effectiveness;Funding;Health;health care delivery;Health Services Research;Health system;Healthcare Systems;improved;Infrastructure;innovation;Institution;Leadership;Learning;Methodology;Mission;Modeling;novel;patient oriented;Personal Satisfaction;Research;research and development;Safety;Scientist;Solid;System;systems research

PROJECT_TITLE: Center for Innovations in Quality, Effectiveness, and Safety (IQuESt)


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Not applicable.

PI_NAMEs: DOBSCHA, STEVEN K (contact)

PROJECT_TERMS: Area;career development;Caring;Collaborations;Decision Making;Dissemination and Implementation;empowerment;Ensure;experience;Faculty;falls;Family;Feedback;Fellowship;Goals;Health;Health Services Research;Healthcare;Healthcare Systems;improved;innovation;Malignant neoplasm of lung;member;Mental Health;Methodology;Mission;non-opioid analgesic;operation;Opioid;Oregon;Pain;Pain management;Patient-Centered Care;Personal Satisfaction;prescription opioid;Process;Research;Research Methodology;Research Personnel;Safety;Science;Self Care;Site;Substance Use Disorder;Suicide prevention;Support System;Technology;Universities;Veterans;whole health

PROJECT_TITLE: Center to Improve Veteran Involvement in Care (CIVIC)


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: The Center for Healthcare Organization and Implementation Research has a mission to conduct organizationally-partnered, and Veteran-partnered research in order to develop, implement, and evaluate evidence-based and innovative practices that improve Veterans Health Administration (VA) healthcare. Our priority goals are: (1) to advance the field of HSR by sustaining, developing, and growing our existing, scientific focus areas, and growing our evolving and emerging scientific areas; (2) to enrich VA's cadre of world-class HSR investigators, by supporting training and education across the career spectrum; and (3) to grow and support innovation in order to maintain VA at the cutting edge of HSR and adapt to meet VA's ever- changing needs.

PI_NAMEs: BOKHOUR, BARBARA G.;GIFFORD, ALLEN L (contact)

PROJECT_TERMS: Address;Adherence;Adverse event;Area;Behavioral;Boston;care coordination;care systems;career;career development;Caring;Collaborations;Communication;community living;connected care;Decision Making;Development;Diffusion of Innovation;Educational process of instructing;Elderly;Elements;Environment;evidence base;Face;Future;Geriatrics;Germination;Goals;health care service organization;Health Service Area;Health Services Administration;Health Services Research;Healthcare;Homelessness;implementation research;improved;Incubators;innovation;International;Justice;K-Series Research Career Programs;Long-Term Care;Long-Term Care for Elderly;Measurement;Measures;Medication Management;Mental Health;Mentors;Mission;Modeling;Operative Surgical Procedures;Outcome;patient oriented;Patient Outcomes Assessments;patient safety;Patient-Centered Care;Patients;Pharmaceutical Preparations;Pharmacologic Substance;pharmacy benefit;Postdoctoral Fellow;Primary Care;Process;programs;Recovery;Research;Research Personnel;Resources;Safety;Scientist;Standardization;success;Suicide prevention;Surgeon;System;team-based care;Technology;Testing;Training and Education;Training Support;Transition Career Development Award (K22);Universities;Veterans;Veterans Health Administration;Vulnerable Populations;whole health;Work


ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: The Veterans Health Administration (VA) provides care for individuals who are more likely to be racial and ethnic minorities, older, and poorer than the general population. Although VA provides a health care safety net, disparities in health and health care exist for many vulnerable Veteran populations and are associated with increased risks of disability, illness, and death. In addition to individual, provider, and health system factors, disparities may originate outside of the health care system and involve personal behaviors and social and community influences. As a health system committed to delivering high-quality, equitable care to all Veterans, VA must identify vulnerable populations, understand the root causes of disparities, and assess interventions to eliminate them. The Center for Health Equity Research and Promotion's mission is to advance the quality and equity of health and health care for vulnerable Veterans.

PI_NAMEs: FINE, MICHAEL JONAH (contact);LONG, JUDITH A

PROJECT_TERMS: Address;behavioral economics;Big Data;Caring;Cessation of life;Clinical;clinical care;clinical epidemiology;Clinical Trials;Collaborations;Communities;community advisory board;Community Healthcare;Data Analyses;Decision Analysis;design;Development;disability risk;Discipline;Disparity;Ensure;Equity;ethnic minority;General Population;Genomics;Goals;Health;Health behavior change;health disparity;health equity;Health equity research;Health Services Research;Health system;Healthcare;Healthcare Systems;implementation science;improved;Individual;Infrastructure;innovation;Institution;Intervention;Knowledge;Leadership;Medical center;medical specialties;medication safety;Mentors;Meta-Analysis;Methods;military veteran;Mission;Outcome;Pattern;Pennsylvania;Personal Behavior;Pharmacologic Substance;pharmacy benefit;Policies;Program Development;programs;Provider;Psychometrics;Publications;Qualitative Research;racial minority;Records;Research;Research Personnel;Research Training;Safety;safety net;Scientific Advances and Accomplishments;Services;Site;social;Technology Assessment;Therapeutic;tool;Training;Training and Education;Translating;Universities;Veterans;Veterans Health Administration;Vulnerable Populations;Work

PROJECT_TITLE: Center for Health Equity Research and Promotion (CHERP)


ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

PHR: The Informatics, Decision-Enhancement, and Analytic Sciences (IDEAS) Center of Innovation will conduct research to advance scientific discovery, implement novel interventions, promote cross-center collaboration, increase research capacity, and engage operational partners to improve Veteran health. Our research will focus on the public health threat of antibiotic resistance, on mitigating health risks in Veterans during periods of vulnerability, and on improving medication safety as the Department of Veterans Affairs (VA) transitions to a new electronic health record. Across all of these areas, we study methods to promote the adoption of research findings into clinical practice. In the process, we train the next generation of outstanding VA health services researchers. Veteran and stakeholder engagement is a topmost priority for our Center. All of our research is highly collaborative and integrated with clinical programs.

PI_NAMEs: SAMORE, MATTHEW H (contact)

PROJECT_TERMS: addiction;Adoption;adverse outcome;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Area;biomedical informatics;Caring;Cities;Clinical;Clinical Investigator;clinical practice;Cognitive;Collaborations;Community Healthcare;Coupled;Data;Decision Making;Decision Support Systems;design;Discipline;Electronic Health Record;Ensure;Environment;Event;Goals;Guidelines;hazard;Health;health care delivery;health information technology;Health Services;Health Services Research;Health system;Healthcare;Healthcare Systems;healthcare-associated infections;implementation science;improved;Infection prevention;Informatics;Infrastructure;innovation;Intervention;Knowledge;Leadership;Learning;Link;medication safety;Medicine;Mental Health;Methodology;Methods;Military Personnel;Modernization;Natural Language Processing;Nature;next generation;novel;Overdose;patient safety;Pharmacoepidemiology;Population;prediction algorithm;Process;programs;Public Health;Qualitative Research;recruit;Research;Research Activity;Research Personnel;Risk;Rural Health;Safety;Science;Scientific Advances and Accomplishments;simulation;Sodium Chloride;Source;stakeholder perspectives;Statistical Models;success;suicidal;System;Therapeutic;tool;Training;Translational Research;Traumatic Brain Injury;Trust;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Vision;Visualization

PROJECT_TITLE: IDEAS 3.0


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Given Veterans' increasing choices about where and how they receive care, successful coordination of care will require improving effective communication among a variety of individuals and entities, as well as improved management and use of health information. This project supports the Center for Health Information and Communication, of the U.S. Department of Veterans Affairs Health Services Research & Development Service. The Center's mission is to improve Veterans' health care through innovative research on health information, technology, and communication. The Center's vision is to improve Veterans' health through innovative applications of health information and health information systems that serve the population-based and interpersonal needs of patients and health professionals. The Center will generate knowledge about the impact of the Department's investment in health information technology, and will determine how systems-based and interpersonal communication of health information can improve delivery and outcomes of care.

PI_NAMEs: WEINER, MICHAEL  (contact)

PROJECT_TERMS: Address;alternative treatment;Area;cancer care;care coordination;care outcomes;career development;Caregivers;Caring;chronic pain;chronic pain management;Clinical;clinical decision support;clinical practice;Communication;Communities;computer human interaction;connected care;Decision Making;Dissemination and Implementation;Documentation;Electronic Health Record;Foundations;Funding;Goals;Health;health application;health communication;Health Information System;health information technology;Health Professional;Health Sciences;Health Services Research;Health Technology;Healthcare;improved;Individual;Information Management;innovation;Investments;Knowledge;Mediation;Mental disorders;Mental Health;Mentors;Mission;Office Management;operation;Opioid;Outcome;Pain management;Patients;person centered;Personal Communication;Pharmaceutical Preparations;Policies;population based;Positioning Attribute;programs;Provider;Publications;Research;research and development;Safety;Science;Scientist;Services;skills;Stroke;System;Technology;tool;Translations;Veterans;Veterans Health Administration;virtual;Vision;Work


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: The VA HSR&D Center for the Study of Healthcare Innovation, Implementation & Policy (CSHIIP) has had a fundamental role in the ongoing transformation of VA health care, through critical examination of multilevel determinants of variations in VA care, development and testing of innovative healthcare delivery models that improve the effectiveness and value of VA care, and impact on VA practice and policy through implementation and spread of evidence-based practice. Our work is anchored in a longstanding history of high-impact research through career development, support, and engagement of a multidisciplinary cadre of investigators, leveraging extensive partnerships that have infused our mission, vision, and values with a deep understanding of VA priorities. These partnerships and priorities have guided our strategic planning, enabling us to build a portfolio of highly responsive research in key focused (primary care, women’s health, high-risk/high-need groups) and emerging areas (complementary/integrative health, specialty care, and emergency management).

PI_NAMEs: YANO, ELIZABETH M (contact)

PROJECT_TERMS: Academy;Acceleration;acute care;Adoption;Affect;Area;care coordination;care delivery;career development;Caring;Collaborations;Communication;Complementary Health;Comprehensive Health Care;Development;Disasters;Discipline of Nursing;Dissemination and Implementation;Doctor of Philosophy;Effectiveness;Emergency Situation;Employee;Employee Engagement;Evaluation;evidence base;Evidence based practice;experience;Funding;Gender;Goals;harassment;Health;Health system;Healthcare;high risk;Home;Homelessness;Homogeneously Staining Region;implementation science;improved;innovation;Integrative Medicine;Intervention;Leadership;Los Angeles;Medical;Medical center;medical schools;medical specialties;Medicine;Mentors;Methodology;Methods;Mission;Modeling;multidisciplinary;Neighborhoods;novel;older adult;operation;Outcome;Paper;Patients;Policies;Primary Care;Provider;provider behavior;Public Health;Publishing;Quality of Care;Readiness;Recording of previous events;recruit;Research;Research Personnel;resilience;Role;Safety;scale up;Scientific Advances and Accomplishments;Service delivery model;Services;severe mental illness;Site;Strategic Planning;substance use;System;Testing;tool;Training;United States Agency for Healthcare Research and Quality;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Variant;Veterans;Vision;whole health;Woman;Women's Health;Women's Health Services;Work;Workplace


ORG_CITY: ANN ARBOR

ORG_STATE: MI

PHR: Not applicable

PI_NAMEs: KERR, EVE A (contact)

PROJECT_TERMS: Achievement;Adverse event;Alcohols;Area;Award;behavioral economics;Cannabis;care coordination;care delivery;career;Caring;Chronic;Cladribine;Clinical;clinical center;Clinical Management;Collaborations;Communities;Community Healthcare;Complex;Critical Illness;Data Collection;Development;digital data;Disease Progression;disorder prevention;Effectiveness;experience;Family;Funding;Future;Health;Health Promotion;Health Services Accessibility;Health Services Research;Healthcare;Healthcare Systems;high risk;Homogeneously Staining Region;Hospitalization;implementation research;improved;Infrastructure;innovation;Inpatients;Intervention;investigator training;Knowledge;Measurement;Measures;Mental Health;mHealth;Michigan;Mission;Modernization;multidisciplinary;opioid misuse;Outcome;patient engagement;patient oriented;Patient Outcomes Assessments;patient safety;Patient-Centered Care;Patients;peer support;Performance;Physicians;Play;predictive modeling;Prevention;Primary Care Physician;Productivity;programs;Reporting;Research;Research Infrastructure;Research Personnel;Role;Safety;Scientist;screening;Services;square foot;suicidal risk;Suicide prevention;System;Technology;theories;tool;Training;United States National Institutes of Health;Veterans;Vision;Wages

PROJECT_TITLE: Ann Arbor COIN Renewal Application


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: This application proposes the continuation of a Center of Innovation (COIN), called the Pain Research, Informatics, Multimorbidities, and Education (PRIME) Center. The COIN builds on the successes of our existing PRIME Center at VA Connecticut Healthcare System. The goals of the PRIME Center are to conduct research to improve care for all Veterans with a specific focus on pain management and women's health. The Center also fosters innovative research in emerging areas like suicide prevention and CHOICE care. Through a Veteran Engagement Group, the Center strives to be Veteran-centric. Investigators provide research mentoring to train the next generation of VA health services researchers. To achieve its goals, the PRIME Center is supported by partnerships with VHA Patient Care Services and Operations leaders, especially the Pain Management Program and Women's Health Services, as well as a large number of cross-COIN and other VHA medical center collaborations.

PI_NAMEs: BASTIAN, LORI A (contact)

PROJECT_TERMS: Area;Award;behavioral health;Behavioral Sciences;care systems;career;career development;Caring;Chronic;Clinical;Collaborations;Complementary Medicine;Connecticut;Disparity;Eating Disorders;Education;Electronic Health Record;Fostering;gender difference;Goals;Health;health data;Health Services;Health Services Research;Healthcare;Healthcare Systems;High Prevalence;implementation research;implementation science;improved;Informatics;Infrastructure;innovation;Institution;Integrative Medicine;Intervention;Leadership;Medical;Medical center;Medical Informatics;medical schools;medical specialties;Mental Health Services;Mentors;Minority;Mission;multimodality;Neurology;New England;next generation;operation;Opioid;Pain;Pain management;Pain Research;Patient Care;Patient-Centered Care;Primary Care;programs;Reproductive Health;Research;Research Methodology;Research Personnel;sex;Strategic Planning;success;Suicide;Suicide prevention;System;Technology;Training;Veterans;Woman;Women's Health;Women's Health Services

PROJECT_TITLE: Pain, Research, Informatics, Multimorbidities, Education


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: The mission of the Center for Care Delivery and Outcomes Research (CCDOR) is to develop and evaluate interventions and implementation strategies that improve health care delivery, Veteran engagement in health care, and Veterans' health and functioning in their communities. CCDOR's vision is to elevate the quality, consistency and equity of health care and outcomes for all Veterans through innovative health services and implementation research. CCDOR is a vibrant health services research center of 26 core investigators leading research in Trauma Recovery (Priority 1) and Chronic Pain and Opioid Harms Reduction (Priority 2), as well as conducting and promoting research in additional areas including cancer prevention and control, health aging, and other timely topics. CCDOR has deep and strong partnerships with VA Program Offices, including the Office of Mental Health and Suicide Prevention, the National Center for PTSD, and National Pain Management. These and other partnerships ensure the value and impact of Center research.

PI_NAMEs: FU, STEVEN  (contact)

PROJECT_TERMS: acronyms;Aging;Area;Cancer Control;cancer prevention;care delivery;care outcomes;chronic pain;Communities;community based participatory research;community engagement;data management;Dedications;Disease;Ensure;Equitable healthcare;Evidence based practice;experience;Family;functional outcomes;Goals;Harm Reduction;Health;health care delivery;Health Services;Health Services Research;health training;Healthcare;Healthcare Systems;healthy aging;implementation research;implementation strategy;improved;Informatics;innovation;Intervention;Mental Health;Mentors;Methodology;Methods;Mission;Names;Opioid;Outcome;Outcomes Research;Pain management;Pain Research;Positioning Attribute;Post-Traumatic Stress Disorders;preservation;programs;Research;Research Personnel;Resources;Services;statistics;Strategic Planning;Structure;success;Suicide prevention;Training;Trauma;Trauma recovery;Veterans;Vision


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Emerging Infectious Diseases;Heart Disease;Infectious Diseases;Women's Health Research

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE There is currently no clear understanding of why an enterovirus like coxsackievirus, that typically targets the gut, would cause myocarditis leading to heart failure. This project will examine whether the ability of coxsackievirus to replicate in the mitochondria of cardiac cells leads to sex differences in myocardial inflammation.

PI_NAMEs: FAIRWEATHER, DELISA  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: 2019-nCoV;Acute;Adult;Age;Animal Model;Autophagosome;Autopsy;Bioenergetics;Biogenesis;Biopsy;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cell Communication;Cells;Child;Complex;COVID-19 patient;Coxsackie Viruses;Data;Diagnosis;Dilated Cardiomyopathy;Disease;Disparate;Enterovirus;ESR1 gene;estrogenic;extracellular vesicles;Female;Goals;Heart;heart damage;Heart failure;Heart Transplantation;Hepatitis C virus;HIV;Homeostasis;Human poliovirus;Immune response;Incidence;Infection;Inflammation;Inflammatory;Influenza A virus;Ingestion;Inner mitochondrial membrane;Lytic;Macrophage;male;Mediating;men;MicroRNAs;Mitochondria;Mitochondrial Proteins;Mus;Myelogenous;Myeloid Cells;Myocardial;Myocarditis;Myocardium;novel;Outer Mitochondrial Membrane;Parkin;Patients;Phosphorylation;Proteins;Proteomics;Publishing;Reporting;response;Risk;Role;Severities;sex;Sex Differences;Signal Transduction;Structure;Sudden Death;Time;TLR4 gene;Transcript;transcriptome sequencing;Tropism;Viral;Viral Proteins;Virus;Virus Diseases;Virus Replication;Woman

PROJECT_TITLE: Role of mitochondrial extracellular vesicles in CVB3 myocarditis by sex

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]