NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Neurosciences;Pediatric;Rare Diseases;Spina Bifida

PI_NAMEs: ECKER, JOSEPH R (contact)

PROJECT_TERMS: 3-Dimensional;Adopted;Algorithms;Anatomy;Animals;Anterior;Area;base;Bioinformatics;bisulfite sequencing;BRAIN initiative;California;Candidate Disease Gene;candidate marker;Carbon;cell type;Cells;Chromatin;Classification;Code;Complex;computerized data processing;cost effective;Cytosine;Data;Data Set;data sharing;Development;Dimensions;Dissociation;DNA Methylation;DNA methylation profiling;DNA Sequence Alteration;Dorsal;Epigenetic Process;epigenetic profiling;epigenome;epigenomics;Folic Acid;Funding;gene environment interaction;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;genetic variant;Genome;genome-wide;Genomics;Global Change;Goals;histone modification;Human;improved;Individual;Informatics;innovation;International;knockout animal;Lateral;Measures;Medial;Meningomyelocele;Methodology;Methods;Methylation;methylome;Modification;Molecular Conformation;multimodality;multiple omics;Mus;Mutate;Mutation;neural;Neural tube;Neuroglia;Neurons;next generation sequence data;Pathway interactions;Patients;Pattern;Phenotype;Post-Translational Protein Processing;Probability;Procedures;Production;Productivity;programs;Publishing;Recording of previous events;Regenerative Medicine;Regulatory Element;Risk;single cell analysis;single cell sequencing;success;synergism;Techniques;Technology;Tissues;transcriptome;United States National Institutes of Health;Untranslated RNA;Validation;Variant;whole genome;Work;Xenopus

PROJECT_TITLE: Core B - Epigenomics Core


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

ORG_STATE: MA

PHR: The goal of this Midcareer Investigator Award is to grow the field of young investigators properly trained in aging research, and to improve the health of frail, older adults through my research efforts focused on unintentional injury. This Award will provide me with the practical experience and formal didactic training to expand my capacity as a researcher, leader, and mentor in patient-oriented research on unintentional injury, including patients with Alzheimer’s Disease and Related Dementias (ADRD).

PI_NAMEs: BERRY, SARAH DYER (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accidental Injury;Advisory Committees;age related;Aging;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Anti-Hypertensive Agents;Anticoagulants;attributable mortality;Award;Benefits and Risks;burnout;career;Caring;Cause of Death;Characteristics;Clinical;Clinical Investigator;Clinical Trials;Collaborations;Competence;Data;design;Development;Discipline;Dislocations;Elderly;Emergency department visit;Exercise;experience;fall injury;falls;feasibility trial;Feedback;Fellowship;Fracture;Funding;Future;Genetic;Geriatrics;Goals;Grant;Health;health care service utilization;Healthcare;Hip Fractures;Hospitalization;Hypoglycemic Agents;implementation science;improved;Ingestion;Injury;Institute of Medicine (U.S.);interest;Intervention;Intracranial Hemorrhages;Investigation;investigator training;K-Series Research Career Programs;large datasets;Lead;Leadership;Link;Literature;Medical;medical schools;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);modifiable risk;Multi-Institutional Clinical Trial;neglect;novel;Nursing Homes;Observational Study;older adult;older patient;older women;Operative Surgical Procedures;Osteoporosis;Overdose;patient oriented;patient oriented research;Patients;Performance;Persons;Pharmaceutical Preparations;Physicians;Physiological;prevent;programs;Reading;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Resources;Risk Factors;Role;Scientific Inquiry;Scientist;shared decision making;skills;Specialist;success;Surgical complication;Syndrome;Testing;Testosterone;Time;Training;Training Programs;Translational Research;trend;vehicular accident;Work

PROJECT_TITLE: Mentoring Patient-Oriented Research to Prevent Injury in Older Adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetic Testing;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: This project will investigate the relationship between imaging characteristics of glioblastoma and its underlying genetic mutations/variants. As such, it aims to develop a number of imaging signatures of mutations that are important in GBM, using 1,159 (709 patients plus an additional 450 tissue samples of 150 of these patients obtained from different locations in the tumor) analyzed via next generation sequencing. The primary motivation of this work is to develop the imaging analytics methodologies and associated biomarkers that will allow us to evaluate the spatial, temporal and molecular heterogeneity of glioblastoma, thereby assisting in patient stratification and treatment.

PI_NAMEs: DAVATZIKOS, CHRISTOS  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Atlases;Biological Markers;Biophysics;Biopsy;Bite;Brain Neoplasms;cancer imaging;Characteristics;chemotherapy;Clinical;clinical imaging;clinical phenotype;clinically actionable;clinically relevant;Combined Modality Therapy;Complex;Data;Data Set;deep learning;Descriptor;design;Diagnosis;Diffusion;DNA Sequence Alteration;Epidermal Growth Factor Receptor;Evaluation;Gene Mutation;Genes;genetic signature;Genotype;Glioblastoma;Glioma;Growth;Heterogeneity;Image;Image Analysis;improved;in vivo;Individual;individual patient;Infiltration;interest;Ligand Binding;Location;Machine Learning;machine learning method;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Neoplasms;Measurement;Measures;Methodology;Methods;Methylation;MGMT gene;Modeling;Molecular;Molecular Analysis;Molecular Profiling;Molecular Target;Morphology;Motivation;Mutation;next generation sequencing;Operative Surgical Procedures;Pathway interactions;patient stratification;Patients;Pattern;Perfusion;personalized diagnostics;personalized predictions;phenomics;Phenotype;Postoperative Period;predictive signature;Prognosis;programs;promoter;Protocols documentation;quantitative imaging;Radiation therapy;Radiogenomics;radiomics;rapid growth;receptor;routine imaging;Sampling;Sampling Errors;Signal Transduction;Spatial Distribution;standard of care;Stratification;Subgroup;Survival Rate;Testing;Texture;Therapeutic Clinical Trial;Tissue Sample;Tissues;tumor;tumor growth;tumor heterogeneity;Variant;Work

PROJECT_TITLE: Imaging signatures of genetic mutations in glioblastoma using machine learning

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine;Prevention

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE The goal of this proposal is to characterize a novel radiotracer we have developed to image oxidative stress caused by risk factors known to inhibit mitochondrial homeostasis and induce neuroinflammation in Parkinson’s disease (PD). Completion of this study will provide crucial insights into the molecular pathways driving prodromal PD to clinical disease and ultimately aid clinicians in early diagnosis and future clinical trial design.

PI_NAMEs: MCMANUS, MEAGAN JOY (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Acceleration;acetovanillone;Address;Age;Aging;aging brain;alpha synuclein;Animal Model;Attenuated;Automobile Driving;Autonomic Dysfunction;behavior test;Bioenergetics;Biological Markers;Blood - brain barrier anatomy;Brain;Brain Diseases;Cells;Clinic;Clinical;clinical application;clinical biomarkers;Clinical Trials Design;clinically relevant;Cognition;design;direct application;Disease;disease diagnosis;disease model;Disease Progression;Dopamine;dopaminergic neuron;Early Diagnosis;Electroencephalography;Ensure;Environment;Environmental Risk Factor;Functional disorder;Future;gene product;genetic risk factor;glial activation;Goals;Homeostasis;hyposmia;Image;Immune;immune activation;Immune signaling;immunogenic;immunogenicity;in vivo;Individual;Inflammation;Inflammatory;inhibitor;insight;Lewy Body Dementia;Link;Lipopolysaccharides;Magnetic Resonance Imaging;Measures;Mediator;Microglia;Mitochondria;mitochondrial dysfunction;mitopark mouse;Modeling;Molecular;Monitor;Moods;motor disorder;motor impairment;mouse model;Mus;Mutation;NADPH Oxidase;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuron loss;novel;Organelles;Outcome;Oxidative Stress;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Phase;Phenotype;Positron-Emission Tomography;predictive marker;pressure;Production;radiotracer;Reactive Oxygen Species;Research;response;Risk;Risk Factors;Role;Signal Transduction;Sleep;Sleep Wake Cycle;Smell Perception;Source;Stimulus;Stress;Superoxides;Susceptibility Gene;System;targeted biomarker;Testing;Therapeutic;Therapeutic Intervention;Toxin;Transgenic Animals;Transgenic Organisms;translatable strategy;Treatment Efficacy;Work

PROJECT_TITLE: Superoxide-sensitive radiotracer as a predictive biomarker of Parkinson's disease progression

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Burden of Illness;Clinical Research;Eye Disease and Disorders of Vision;Multiple Sclerosis;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This research proposal has public health relevance because myelin oligodendrocyte glycoprotein antibody disease (MOGAD) can result in blindness, wheelchair dependence or coma and the fundamental epidemiology knowledge we provide will determine its global burden, guide resource allocation, provoke research into risk factors by identifying regional variation and help clinical trial readiness by allowing better prediction of recruitment. Moreover, the findings from this proposal will provide information that physicians can immediately incorporate into clinical practice to guide diagnostic and therapeutic decision making in MOGAD patients. The proposed research is relevant to the NIH mission because it will improve outcomes, reduce harm, and lead to better understanding of MOGAD pathogenesis which is a potential first step towards developing novel treatments in this disease.

PI_NAMEs: FLANAGAN, EOIN P (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Acute Disseminated Encephalomyelitis;Antibodies;aquaporin 4;biobank;Biological Assay;Biological Markers;blind;Blindness;Case Study;Cells;Cerebrospinal Fluid;Characteristics;Child;Classification;Clinic;Clinical;Clinical Laboratory Improvement Amendments;clinical practice;clinical trial readiness;Clinical Trials Design;cohort;Coma;Complement;Complement Inactivators;Data;Decision Making;Demyelinating Diseases;Demyelinations;Dependence;Deposition;Detection;Development;Diagnosis;Diagnostic;diagnostic value;Disease;Epidemiology;Evaluation;Evolution;experience;Flow Cytometry;Frequencies;Goals;Harm Reduction;Healthcare;Immunoglobulin G;immunopathology;improved outcome;Incidence;Inflammatory;Inflammatory Infiltrate;innovation;insight;Knowledge;Lesion;Magnetic Resonance Imaging;Measurement;Measures;Mission;Multiple Sclerosis;Multiple Sclerosis Lesions;Myelitis;Nature;Neuromyelitis Optica;novel;novel therapeutics;oligodendrocyte-myelin glycoprotein;Optic Neuritis;Outcome;outcome prediction;Paralysed;Pathogenesis;Pathologic;Pathology;Patient Care;Patients;Pattern;Phase;Physicians;Population;population based;Prevalence;Process;Prognosis;prognostic value;prospective;public health relevance;Rare Lesion;recruit;relapse prediction;relapse risk;Research;Research Proposals;Resource Allocation;resource guides;Retrospective Studies;Risk Factors;Safety;seropositive;Serum;standard of care;Testing;Therapeutic;tissue injury;tissue repair;treatment strategy;United States National Institutes of Health;Variant;Wheelchairs

PROJECT_TITLE: Myelin oligodendrocyte glycoprotein antibody disease: incidence, prevalence, outcome prediction and immunopathology

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases;Spina Bifida

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PI_NAMEs: BAFNA, VINEET  (contact)

PROJECT_TERMS: Algorithms;analysis pipeline;Area;Bioinformatics;bioinformatics pipeline;bisulfite sequencing;Candidate Disease Gene;candidate identification;Cell Differentiation process;Cells;Code;Computer Analysis;computer science;Computing Methodologies;Data;Data Analyses;data harmonization;data pipeline;Data Set;Data Sources;Databases;Detection;Development;dietary;differential expression;DNA methylation profiling;DNA Sequence Alteration;DNA sequencing;Elements;Epigenetic Process;Ethnic Origin;exome sequencing;Folic Acid;gene environment interaction;Gene Frequency;gene interaction;Genes;Genetic;Genetic Transcription;genetic variant;Genomics;Genotype;Goals;Human;improved;in silico;Inherited;innovation;large datasets;Massive Parallel Sequencing;Meningomyelocele;method development;Methods;Methylation;methylome;Mining;Minisatellite Repeats;Modality;Modeling;Modernization;Molecular Biology;multiple omics;Mus;Mutation;Neural tube;next generation sequencing;novel;Parents;Pathogenicity;Pathway Analysis;Pathway interactions;Patients;Phenotype;Population;Productivity;programs;Promoter Regions;protein expression;protein function;protein protein interaction;Proteins;Rana;Reproducibility;Research Personnel;Risk;risk variant;Sampling;Science;segregation;Services;Short Tandem Repeat;single cell analysis;single cell sequencing;single-cell RNA sequencing;Statistical Models;statistics;Tandem Repeat Sequences;Techniques;Technology;Tissues;transcriptome sequencing;Validation;Variant;Visualization;whole genome;Work

PROJECT_TITLE: Core C- Bioinformatics Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Clinical Research;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Sleep Research

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Survival of infants born extremely prematurely has improved, but these babies go on to experience high rates of childhood health problems including asthma, breathing abnormalities during sleep, and poor developmental outcomes. Currently, the mechanisms causing such outcomes remain unclear, impairing the ability of the clinician to identify both at-risk infants and targets for intervention. This study will utilize advanced analytics platforms paired with detailed health outcomes through pre-school age in a cohort of prematurely born children to further our understanding of the pathways leading to abnormal outcomes in these children, empowering early identification and targeted treatment to improve health outcomes.

PI_NAMEs: AMBALAVANAN, NAMASIVAYAM ;CLAURE, NELSON R;HIBBS, ANNA MARIA ;LAKE, DOUGLAS E;WEESE-MAYER, DEBRA ELLYN (contact)

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: Acceleration;advanced analytics;Affect;Age;Age Months;airway hyperresponsiveness;Asthma;asthma model;Breathing;Bronchopulmonary Dysplasia;Caffeine;Characteristics;Child;Child Care;Childhood;Clinical;clinical care;Clinical Data;clinical phenotype;Clinical Treatment;Cognitive;cohort;Collaborations;Consent;cost;Data;Development;Diagnosis;Discipline of Nursing;Disease;Early Diagnosis;Early identification;Early Intervention;early screening;Emotional;empowerment;Enrollment;Event;experience;extreme prematurity;Frequencies;Funding;Future;Goals;Health;Hypoxemia;Impairment;improved;infancy;Infant;Infrastructure;innovation;Institution;Intervention;Intervention Trial;Investigation;Knowledge;Life;Link;Measures;Motor;National Heart, Lung, and Blood Institute;Neonatal;neonatal airway;neonatal care;Neonatal Intensive Care;Neonatal Intensive Care Units;Nervous System Physiology;Neurodevelopmental Impairment;novel therapeutics;Nursery Schools;Outcome;Oxygen;Pathologic;Pathway interactions;Patients;Pattern;peer;Persons;Pharmaceutical Preparations;Physiological;Population;postnatal;Pregnancy;premature;Premature Birth;Premature Infant;Prevalence;Prevention strategy;Preventive;Prognosis;prognostic;prognostic model;programs;Prospective Studies;Protocols documentation;Records;Rehabilitation therapy;Research;Research Personnel;Resolution;Resources;respiratory;Respiratory physiology;response;Risk;Rodent;Role;School-Age Population;Sensory;Services;Sleep;Sleep Apnea Syndromes;standard of care;Structure;supplemental oxygen;System;targeted treatment;Therapeutic;Time;Training;United States National Institutes of Health;Vent;Weaning;Work

PROJECT_TITLE: Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Insight into the mechanisms of retinal synaptic partner choice will be relevant to public health because, once we understand these mechanisms, it may become possible to manipulate them for therapeutic benefit. For ex- ample, knowledge about these cell-cell recognition molecules could be used to design rational strategies for integrating new neurons into existing circuits. Such strategies could ultimately lead to new therapeutic options for treating retinal degenerative disease, or even neurodegenerative disorders in other regions of the central nervous system.

PI_NAMEs: KAY, JEREMY N (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Adhesives;Axon;Binding;Biochemical;Biological Assay;Cell surface;Cell Surface Proteins;cell type;Cells;Central Nervous System;Cues;Data;Dendrites;Development;Disease;Event;Exclusion;Failure;Family;gain of function;ganglion cell;genetic approach;Goals;Growth;Image;Impairment;in vivo;Inner Plexiform Layer;insight;Knock-out;Knowledge;Ligands;Location;Logic;loss of function;Mediating;Modeling;Molecular;Mus;mutant;Mutant Strains Mice;neural circuit;Neurites;Neurodegenerative Disorders;neuronal circuitry;Neurons;Neuropil;novel therapeutics;Phenocopy;Physiological;prevent;Process;Property;Proteins;Public Health;rational design;receptor;regenerative therapy;Retina;Retinal Degeneration;retinal neuron;segregation;Signal Transduction;Specificity;starburst;starburst amacrine cell;Synapses;synaptogenesis;Testing;Therapeutic;Vision;Visual Perception;Work

PROJECT_TITLE: Precise assembly of retinal circuitry through rejection of inappropriate synaptic partners

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Eye Disease and Disorders of Vision;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Neurodegeneration underlies progressive decline in Multiple Sclerosis (MS) for which there is no remedy, highlighting the significance of elucidating its mechanisms. In patients with MS, retinal ganglion cell loss and retinal thinning correlate with whole-brain and gray matter atrophy, supporting that visual assessments may be a sensitive biomarker for neurodegeneration. Our work suggests that preventing excitotoxic damage to myelin prevents optic nerve axonal loss and retinal ganglion cell degeneration providing an important mechanism underlying neurodegeneration.

PI_NAMEs: DESILVA, TARA MARIA (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: 3-Dimensional;Address;Adult;Appearance;Atrophic;Attenuated;Autoimmune;Axon;axon injury;Biological Markers;Brain;Calcium;Cell Death;Cells;Chronic;Clinical;Clinical Trials;Cytosol;Data;Demyelinating Diseases;Demyelinations;Disease remission;efficacy evaluation;Electron Microscopy;Electroretinography;Excitatory Amino Acid Antagonists;Excitatory Neurotoxins;excitotoxicity;Exhibits;Experimental Autoimmune Encephalomyelitis;experimental study;Genetic;Gliosis;Glutamate Receptor;Glutamates;Grant;gray matter;Health;Image;Immune;Inflammatory;Inflammatory Response;Injections;Knockout Mice;Laboratories;Lateral Geniculate Body;Lesion;Light;Link;Location;Magnetic Resonance Imaging;Maps;Measures;Mediating;Microglia;Mitochondria;Morphology;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelin;Natural regeneration;Nerve Degeneration;neuroinflammation;neuron loss;neuronal cell body;Neurons;neuroprotection;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Optic Nerve;Optical Coherence Tomography;Outcome;Pathologic;Peripheral;Permeability;Pharmaceutical Preparations;preservation;prevent;Process;Proliferating;Publishing;receptor function;Receptor Signaling;reconstruction;Relapse;remyelination;repaired;Reporter;Reporting;response;Retina;Retinal Degeneration;retinal ganglion cell degeneration;Retinal Ganglion Cells;Severities;Severity of illness;Source;Spinal Cord;stem cells;Symptoms;System;T cell infiltration;T-Lymphocyte;Testing;Thinness;Time;trafficking;Transgenic Mice;Ventral Posterolateral Nucleus;Vision;Visual;Visual evoked cortical potential;Visual System;white matter;Wild Type Mouse;Work

PROJECT_TITLE: Mechanisms of retinal degeneration in neuroinflammatory demyelinating diseases


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dietary Supplements;Genetics;Human Genome;Neurosciences;Pediatric;Prevention;Rare Diseases;Spina Bifida

PI_NAMEs: GLEESON, JOSEPH G (contact)

PROJECT_TERMS: Algorithms;Alleles;American;Animal Model;autism spectrum disorder;Bioinformatics;Birth;Brain Stem;Candidate Disease Gene;candidate identification;Child;Childhood;Clinical;cohort;Conceptions;Congenital Abnormality;Consultations;Copy Number Polymorphism;Coupled;Creation of ventriculo-peritoneal shunt;Data;data harmonization;data integrity;de novo mutation;Defect;Development;dietary;disability;Disease;DNA;Drops;Enrollment;Ensure;Epigenetic Process;Exclusion Criteria;exome sequencing;Family;Folic Acid;Folic acid fortification;folic acid supplementation;Future;gene environment interaction;gene function;Gene Mutation;gene network;Genes;Genetic;genetic architecture;Genetic Transcription;genetic variant;genome sequencing;genomic variation;Genotype;Health Care Costs;Heritability;Human;human disease;Human Genetics;human model;Incidence;inclusion criteria;Individual;Inherited;International;Learning Disabilities;Life;Link;Meningomyelocele;Methylation;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;Mus;Mutate;Mutation;Mutation Analysis;National Institute of Child Health and Human Development;Neural tube;Neural Tube Defects;Odds Ratio;Outcome;Patients;Phenotype;prenatal;programs;Proteins;Protocols documentation;Rana;recruit;Recurrence;Repeat Surgery;Risk;Risk Factors;risk mitigation;Sampling;Seizures;Shunt Device;social media;Spinal Dysraphism;Structural Congenital Anomalies;System;Testing;Time;tool;Variant;whole genome;Work

PROJECT_TITLE: Project I - Human genetics of meningomyelocele and risk mitigation by folic acid


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Food Allergies;Inflammatory Bowel Disease;Microbiome;Nutrition;Pediatric;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Food allergy prevalence in children is dramatically rising and can be life-threatening while the biological explanations remain unclear. Utilizing a large prospective longitudinal healthy infant cohort I built to identify pediatric mucosal and allergic diseases, I propose to study the role of the intestinal microbiome in the development of one of the earliest manifestations of food allergy in children. Integrated analyses of comprehensive prospective clinical metadata, dense longitudinal biological sampling, and carefully defined allergic outcomes will allow us to identify important microbial and inflammatory pathways and immunologic responses, useful biomarkers, and novel targets for food allergy prevention.

PI_NAMEs: MARTIN, VICTORIA MACKENZIE (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acids;Advisory Committees;Age;Age Years;Allergic;Allergic Disease;Allergic inflammation;Antibiotics;Antigens;Area;Atopic Dermatitis;atopy;Award;Biological;Biological Markers;biomarker validation;Biometry;candidate identification;candidate marker;Child;Childhood;Clinical;Clinical effectiveness;Clinical Research;Clinical Sciences;cohort;Cohort Studies;Colonic inflammation;Complex;Computer Models;Data;design;Development;Diagnosis;Diet;dietary;Disease;Doctor of Philosophy;dysbiosis;Enrollment;Ensure;Enterobacteriaceae;Environment;Environmental Risk Factor;eosinophil;Eosinophil-Derived Neurotoxin;Epidemiology;experience;Food;food antigen;Food Hypersensitivity;Foundations;Functional disorder;Funding;Gastroenterologist;Gastroenterology;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal Physiology;Gastrointestinal tract structure;General Hospitals;Goals;gut inflammation;gut microbiome;Hypersensitivity;IgE;Immune response;Immune Tolerance;Immunology;Incidence;infancy;Infant;Inflammatory;Innate Immune System;insight;instructor;leadership development;Leukocyte L1 Antigen Complex;Life;Longitudinal Studies;Massachusetts;Master of Public Health;Mediating;medical schools;Mentors;Mentorship;Metadata;metagenomic sequencing;method development;microbial;microbiome;microbiome analysis;Modeling;Mucosal Immune System;Mucous Membrane;novel;novel marker;Onset of illness;Outcome;Pathway interactions;Pediatrics;Pharmaceutical Preparations;Phenotype;Physicians;Positioning Attribute;post-doctoral training;Prevalence;Prevention;Proctocolitis;prospective;Prospective Studies;Proteins;Research;research and development;Research Design;Research Personnel;Resources;Risk;Role;Sampling;Scientist;Shotguns;success;Symptoms;System;Systems Biology;Testing;Training;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Systems approach to elucidate the microbiome's influence on the development of food allergies early in life

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Social Determinants of Health

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: NARRATIVE The long-term goal of the Dynamic Experiences in Neuroscience to Diversify Research Internship Training Exposures for Students (DENDRITES) Program is to diversify the neuroscience workforce. The DENDRITES program aims to encourage and support the research and career development of students from underrepresented backgrounds in biomedical sciences. We will accomplish this goal by exposing undergraduate students to cutting-edge research opportunities while being supported by faculty and graduate student mentors and providing students with an assortment of structured professional development workshops, during a nine-week summer program.

PI_NAMEs: PRABHAKARAN, SHYAM  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Academia;Admission activity;Appointment;Articulation;Black race;Brain;career;career development;Chicago;Clinical;Collaborations;Degree program;design;Development;Doctor of Philosophy;Doctor's Degree;Early identification;education resources;Educational workshop;Enrollment;Ethics;ethnic disparity;experience;experimental study;Exposure to;Faculty;faculty support;Generations;Goals;graduate school;graduate student;Group Meetings;hands on research;Home;improved;Indigenous;Institution;interest;Internships;intrinsic motivation;Knowledge;Latinx;Leadership;Learning;Low income;member;Mentors;Methodology;Mission;National Institute of Neurological Disorders and Stroke;Nervous System;Nervous System Disorder;Neurosciences;Neurosciences Research;Not Hispanic or Latino;Oral;Participant;Pathway interactions;Process;programs;Qualifying;racial disparity;Reporting;Research;research and development;Research Personnel;Research Support;Resources;rural environment;School Admission Criteria;Schools;Science;Scientific Inquiry;Series;skills;Structure;student mentoring;Student recruitment;Students;summer program;summer research;symposium;Techniques;Technology;Training;translational neuroscience;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;Universities;university student;Visit;Writing

PROJECT_TITLE: Dynamic Experiences in Neuroscience to Diversify Research Internship Training Exposure for Students (DENDRITES)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Kidney Disease

ORG_CITY: AUGUSTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Narrative: The goal of this application is to investigate the pathogenic function and regulation of long non-coding RNA (lncRNA) with GSTM3P1 as an example to study the related pathways in renal tubular cell death and to identify new strategies for AKI therapy. Our expect outcomes include: (1) identifying GSTM3P1 and GSTM3 as new therapeutic targets for AKI; (2) extending the knowledge of lncRNA function in AKI, (3) extending the knowledge of regulation between lncRNA and miRNA; (4) extending the knowledge of protein expression regulation by lncRNAs. Our findings will have impact on (1) the AKI research field by elucidating the pathological role of lncRNA GSTM3P1 and its downstream regulation of mir-668 and GSTM3; and (2) the other medical research fields for the novel understanding of interaction between miRNA and lncRNA and protein expression regulation by lncRNA from pseudogene.

PI_NAMEs: WEI, QINGQING  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Affect;Binding;Binding Sites;Blood Vessels;Cardiac Surgery procedures;Cardiovascular Diseases;Cell Death;Cells;Cessation of life;Chronic Kidney Failure;Clinical;Cytosol;Functional disorder;Genetic Transcription;Goals;GSTM3 gene;Homologous Gene;Human;Hypoxia;improved;In Vitro;in vivo;Injury;Injury to Kidney;Ischemia;Kidney;kidney cortex;Kidney Diseases;Kidney Failure;Knockout Mice;Knowledge;Lead;Medical Research;MicroRNAs;mortality;mouse model;Mus;Myocardial Infarction;new therapeutic target;novel;novel therapeutics;Obstruction;Outcome;overexpression;Oxidative Stress;Pathogenicity;Pathologic;Pathway interactions;prevent;protective effect;protective factors;protein expression;Protein Family;Proteins;Pseudogenes;Rattus;Regulation;renal ischemia;Research;Resistance;RNA-Induced Silencing Complex;Role;Sepsis;Survival Rate;Testing;therapy development;Transcript;Tubular formation;Untranslated RNA;Up-Regulation;urinary

PROJECT_TITLE: The regulation and function of long non coding RNA in ischemic AKI: Role of GSTM3P1

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Mood disorders are associated with significant financial and health costs for the United States, partially due to cognitive problems in these patients that can worsen disease course and impair treatment response. This study proposes to use smartphone-based technology to monitor cognitive problems in patients with mood disorders by linking brain network changes with predicted worsening of mood symptoms. The proposed study will provide evidence for using smartphone-based passive sensing as a cost-effective way to predict illness course and treatment response.

PI_NAMEs: AJILORE, OLUSOLA A. (contact);LEOW, ALEX

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Address;Affective Symptoms;Apple;associated symptom;Attention;Biological Markers;Bipolar Disorder;Brain;Cellular Phone;Clinical;Clinical assessments;clinically relevant;Cognition;Cognitive;cognitive function;Collection;computer human interaction;Consumption;cost effective;Custom;Data;depressive symptoms;Devices;Diagnostic;Diffusion;Disease;Disease remission;Dysthymic Disorder;Ecological momentary assessment;Environment;evidence base;Financial cost;Functional Imaging;handheld mobile device;Health Care Costs;Image;Impaired cognition;Impairment;Improve Access;Individual;interest;kinematics;Link;Literature;Manic;Measures;Mediating;Methods;Monitor;Mood Disorders;mood symptom;Moods;Motor;multimodal neuroimaging;network dysfunction;neuroimaging;Neuropsychological Tests;Nodal;novel;Outcome;Participant;Patients;Pilot Projects;processing speed;Property;prospective;Recurrence;Research;Rest;Risk Factors;Sampling;screening;Secure;Structure;Symptoms;Tablets;Technology;Time;treatment response;Unipolar Depression;United States;virtual;white matter

PROJECT_TITLE: Unobtrusive Monitoring of Affective Symptoms and Cognition using Keyboard Dynamics

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The proposed research study is relevant to public health because it focuses on neuroprotection, which is an emerging therapeutic strategy for myriad neurological disorders. Our studies will explore the molecular basis of cellular protection provided by innate intracellular stress response pathways, with an emphasis on oligodendrocytes, the myelinating cells of central nervous system.

PI_NAMEs: POPKO, BRIAN J (contact)

PROJECT_TERMS: activating transcription factor 4;Animals;Antioxidants;Award;axonal degeneration;biological adaptation to stress;Cell Lineage;Cell Migration Induction;Cells;Cellular Stress;Central Nervous System;cytokine;Cytoplasm;Cytoprotection;cytotoxic;Data;Demyelinating Diseases;Demyelinations;design;Development;endoplasmic reticulum stress;Eukaryotic Cell;Eukaryotic Initiation Factors;experience;Exposure to;extend lifespan;Foundations;Funding;Gene Expression;Genes;Genetic Models;Human;Hyaluronidase;Immune;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;insight;Interferon Type II;leukodystrophy;Link;Literature;Mediating;Messenger RNA;Modeling;Molecular;mouse model;Multiple Sclerosis;multiple sclerosis treatment;mutant;Mutant Strains Mice;Mutation;Myelin Proteolipid Protein;myelination;Nervous System;Nervous System Disorder;neuroprotection;nuclear factor-erythroid 2;oligodendrocyte lineage;Oligodendroglia;oxidative damage;Pathway interactions;Pelizaeus-Merzbacher Disease;PERK kinase;pharmacologic;Phosphorylation;Play;Positioning Attribute;Predisposition;Prokaryotic Initiation Factor-2;Proteins;Proteolipids;Public Health;remyelination;Reporting;research study;Resistance;response;response biomarker;Role;sensor;Stress;stress granule;Testing;Therapeutic;therapeutically effective;Transcript;transcription factor;Translations;unpublished works;Work

PROJECT_TITLE: Targeting the Integrated Stress Response to Protect Oligodendrocyte lineage Cells

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Services;Infectious Diseases;Lung;Pediatric

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The proposed project is a multicenter clinical trial that seeks to determine the efﬁcacy of Azithromycin for the treatment of severe wheezing in preschoolers who present to the Emergency Department. The trial will also determine the prevalence of bacteria and viruses associated with these events and any correlation with respon- siveness to Azithromycin. The trial will be conducted at six clinical sites from the Pediatric Emergency Care Applied Research Network (PECARN).

PI_NAMEs: CASPER, THERON C (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: 6 year old;Accident and Emergency department;Acute;Admission activity;age group;aged;airway obstruction;Ambulatory Care Facilities;Anti-Bacterial Agents;Antibiotics;Antiinflammatory Effect;Applied Research;arm;Asthma;Azithromycin;Bacteria;Bacterial Infections;bacterial resistance;Biological;Biometry;Cephalosporins;Child;Clinical;clinical research site;clinical trial analysis;Clinical Trials;Clinical Trials Design;Communication;Data Collection;Data Coordinating Center;data management;Data Set;design;Diagnosis;disability;Double-Blind Method;efficacy evaluation;efficacy testing;Emergency Care;Emergency department visit;emergency settings;Event;experience;Future;Genetic;Goals;Guidelines;Health Care Costs;health care service utilization;high risk;Hospitalization;hospitalization rates;Human Resources;improved;Leadership;Life;Lower respiratory tract structure;Macrolides;Maintenance;Manuals;Microbe;microbial;microbial community;Monitor;Multi-Institutional Clinical Trial;Nasopharynx;Nursery Schools;operation;Outcome;pathogenic bacteria;pediatric emergency;Penicillins;Pharyngeal structure;Placebo Control;Placebos;Play;Population;Preparation;Preschool Child;Prevalence;Production;Property;Protocols documentation;psychologic;Qualifying;Randomized;Recommendation;Reporting;Research;Research Personnel;Resistance;respiratory;response;Risk;Risk Factors;Role;Sampling;School-Age Population;Severities;social;Source;Specimen;symptomatic improvement;Symptoms;Technical Expertise;Testing;Toddler;Training;treatment guidelines;United States;Universities;Utah;Virus;Wheezing

PROJECT_TITLE: 2/2: AZithromycin Therapy in Preschoolers with a Severe Wheezing Episode Diagnosed at the Emergency Department (AZ-SWED)


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Human Genome;Neurosciences;Pediatric;Prevention;Rare Diseases;Spina Bifida

PI_NAMEs: KINTNER, CHRISTOPHER ROBERT (contact)

PROJECT_TERMS: 22q11;22q11.2;Address;Alleles;Animals;Benign;Biological Assay;Biological Models;Birth;Candidate Disease Gene;Cells;Chromatin;Chromosome Deletion;CISH gene;Clinical;Collaborations;Complex;Congenital Abnormality;Coupled;Data;de novo mutation;Development;DiGeorge Syndrome;Disease;DNA Methylation;Dose;Effectiveness;Embryo;Environmental Risk Factor;Etiology;Event;Experimental Models;experimental study;Fetus;Folic Acid;Folic Acid Deficiency;Foundations;Gene Deletion;gene environment interaction;Gene Expression;gene interaction;Genes;Genetic;genetic risk factor;genetic testing;genetic variant;Goals;Heterozygote;Human;in vivo;Incidence;Individual;Injections;Knock-out;Literature;loss of function mutation;Mammals;Measures;Meningomyelocele;Messenger RNA;Modeling;Molecular;Morphogenesis;mouse model;Movement;Mus;Mutagenesis;mutant;Mutate;Mutation;Nature;Neural tube;Neural Tube Closure;Neural Tube Defects;Neural Tube Development;next generation sequencing;null mutation;Organ;Pathway interactions;Patients;pharmacologic;Phenotype;planar cell polarity;Play;Process;programs;Rana;Recurrence;Risk;Risk Factors;Role;Spinal;Study models;Syndrome;Testing;Tetrapoda;transcriptome sequencing;Variant;variant detection;Work;Xenopus;xenopus genome;Xenopus laevis

PROJECT_TITLE: Project II - Modeling meningomyelocele in frog using human alleles and folic acid exposure


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Project Narrative Biologists studying a huge variety of diseases and basic biological processes need software to measure cells, tissues, and organisms in microscopy images. We will create the Center for Open Bioimage Analysis which will catalyze the scientific community, creating resources, free software, and training that allow biologists to analyze images using deep learning and other new image processing algorithms, offering improved accuracy, convenience, and reproducibility.

PI_NAMEs: CARPENTER, ANNE E.;CIMINI, BETH  (contact);ELICEIRI, KEVIN WILLIAM

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Address;advanced analytics;Algorithms;Area;Automobile Driving;Benchmarking;bioimaging;Biological;Biological Models;Biological Process;biological research;biological systems;Biology;Biomedical Research;catalyst;Cells;Cellular biology;Cellular Structures;Collaborations;Communities;community engagement;community organizations;Complex;Computational algorithm;Computational Technique;computer scientist;Computer software;Computer Vision Systems;Data;Data Analyses;Data Science;deep learning;Development;Dimensions;Disease;Educational workshop;empowerment;Ensure;Event;experimental study;Feedback;hackathon;Hand;Image;Image Analysis;image processing;imaging modality;imaging software;improved;Infrastructure;innovation;International;Laboratories;light microscopy;Measures;Methods;microscopic imaging;Microscopy;Mission;Modality;Modeling;Modernization;next generation;novel;open source;Organism;Organoids;quantitative imaging;Reproducibility;Research;research and development;Research Personnel;Resource Sharing;Resources;Role;Side;skills;Software Engineering;symposium;System;Technology;technology research and development;Tissues;tool;Training;training data;Translating;Universities;usability;user friendly software;user-friendly;Wisconsin;Work

PROJECT_TITLE: Center for Open Bioimage Analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(40)P]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: CARPENTER, ANNE E. (contact)

PROJECT_TERMS: Acceleration;Address;advanced analytics;Advisory Committees;Algorithms;Area;Automobile Driving;bioimaging;Biological;Biological Models;Biological Process;biological research;Biology;Biomedical Research;catalyst;Cells;Cellular biology;Collaborations;Communication;Communities;community engagement;Computational Technique;computer scientist;Computer software;deep learning;Development;Development Plans;Dimensions;Disease;empowerment;Ensure;Event;experimental study;Feedback;hackathon;Human Resources;Image;Image Analysis;image processing;imaging modality;improved;Infrastructure;innovation;International;Laboratories;light microscopy;Measures;member;Methods;microscopic imaging;Microscopy;Mission;Modality;Monitor;next generation;novel;open source;Organism;organizational structure;quantitative imaging;recruit;Reproducibility;Research;research and development;Research Personnel;Resource Sharing;Resources;Role;Side;Site;skills;Software Engineering;Strategic Planning;symposium;Technology;technology research and development;Tissues;tool;Training;Translating;Universities;usability;user friendly software;user-friendly;Wisconsin;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Acceleration;Active Learning;Address;advanced analytics;Algorithms;Area;Automobile Driving;Benchmarking;bioimaging;Biological;Biological Models;Biological Process;biological research;Biology;Biomedical Research;catalyst;Cell Nucleus;Cells;Cellular biology;Cellular Structures;Communities;Complement;Complex;Computational Technique;computer scientist;Computer software;Computer Vision Systems;Data;Data Set;deep learning;deep learning model;deep neural network;Development;diagnostic tool;Dimensions;Disease;empowerment;Ensure;Event;experience;experimental study;Face;Feedback;Friends;Future;graphical user interface;Image;Image Analysis;image processing;imaging modality;improved;innovation;interest;International;Laboratories;learning strategy;Letters;light microscopy;Machine Learning;machine learning method;Measures;Methods;microscopic imaging;Microscopy;Mission;Modality;Modeling;neural network;next generation;Online Systems;open source;Organism;Phenotype;Process;quantitative imaging;Recommendation;Reproducibility;Research;research and development;Research Personnel;Resource Sharing;Resources;Risk Reduction;Role;scale up;Side;skills;software development;Software Engineering;Software Tools;Structure;System;Techniques;Technology;technology research and development;Time;Tissues;tool;Training;training data;Translating;Universities;usability;user friendly software;user-friendly;Validation;Variant;Wisconsin;Work


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Despite decades of research, pancreatic ductal adenocarcinoma remains one of the deadliest of cancers, but recent advances in heavy-ion radiotherapy and in ferroptosis-inducing drugs may begin to change this. This proposal will investigate the relationship of linear energy transfer with tumor killing and associated endpoints, as well as how these interact with the induction of ferroptosis. The knowledge gained will help to develop optimized approaches to heavy ion radiotherapy, potentially making it both more clinically effective and more cost effective to improve outcomes for pancreatic cancer and other hard-to-treat tumors.

PI_NAMEs: AMUNDSON, SALLY A. (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: 3D ultrasound;Address;advanced pancreatic cancer;Aftercare;animal imaging;anti-cancer;anti-cancer research;Biology;Carbon ion;Cell Death;cell killing;Cell Line;Cell Proliferation;Cells;Cessation of life;Charge;Clinical;clinically relevant;Collimator;Combined Modality Therapy;Complex;cost effective;Custom;Cysteine;Cystine;Dependence;Deposition;Development;Distant Metastasis;DNA Damage;Dose;Drug Metabolic Detoxication;Engineering;gemcitabine;Generations;Genetically Engineered Mouse;Glutathione;Goals;Heavy Ions;Helium;high-LET heavy ion therapy;High-LET Radiation;Hospitals;Human;imaging capabilities;immune cell infiltrate;Immune response;improved;improved outcome;in vivo;Ionizing radiation;Ions;irradiation;Knowledge;KPC model;Laboratories;laboratory facility;Linear Energy Transfer;Link;Lipid Peroxidation;Local Therapy;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;meter;Microscopic;Modality;Molecular;mouse model;Mus;neoplastic cell;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;particle beam;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Physics;pre-clinical;Protons;Radiation;radiation response;Radiation therapy;Radiobiology;Radiology Specialty;Reactive Oxygen Species;Relative Biological Effectiveness;relative effectiveness;Reporting;Research;Resistance;Resolution;Roentgen Rays;serial imaging;Signal Transduction;Therapeutic;Time;tumor;tumor growth;Tumor Markers;United States National Aeronautics and Space Administration;x-ray irradiation

PROJECT_TITLE: Linear energy transfer (LET) dependencies for understanding pancreatic tumor control and relevant molecular endpoints in support of RBE-based heavy-ion radiotherapy


PROJECT_TERMS: Acceleration;Address;advanced analytics;Algorithmic Analysis;Algorithms;Area;Automobile Driving;bioimaging;Biological;Biological Models;Biological Process;biological research;biological systems;Biology;Biomedical Research;catalyst;Cells;Cellular biology;Communities;Complex;Computational Technique;computer scientist;Computer software;Data Analyses;deep learning;deep learning model;Development;Dimensions;Disease;empowerment;Ensure;Event;experimental study;Feedback;Image;Image Analysis;image processing;imaging modality;imaging software;improved;Infrastructure;innovation;International;Java;Laboratories;Letters;Libraries;light microscopy;Manuals;Measures;microscopic imaging;Microscopy;migration;Mission;Modality;Modeling;next generation;open source;Organism;Pythons;quantitative imaging;Reproducibility;Research;research and development;Research Personnel;Resource Sharing;Resources;Role;Route;Scientist;Side;skills;Software Engineering;software infrastructure;Source;System;Technology;technology research and development;Time;Tissues;tool;Training;Translating;Universities;Update;usability;user friendly software;user-friendly;wasting;Wisconsin;Work


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Dissemination and Implementation Research;Health Services;Infectious Diseases;Lung;Patient Safety;Pediatric

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Public Health Relevance Increasingly, mechanically ventilated children are at risk for respiratory infections that are resistant to antibiotics. This proposal will support the career development and research of Dr. Sick-Samuels to advance the understanding of best practices to manage the evaluation of respiratory infections in mechanically ventilated children.

PI_NAMEs: SICK-SAMUELS, ANNA  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Address;Adverse event;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;aspirate;Attitude;Award;Bacteremia;Bacterial Antibiotic Resistance;Bacterial Infections;Behavior;Biometry;care outcomes;career development;Caring;Child;Childhood;Chronically Ill;Classification;Clinical;clinical decision support;Clinical Research;Clinical Trials;cohort;Collection;Communicable Diseases;Complex;Complication;Consolidated Framework for Implementation Research;Critical Care;Critically ill children;Data;Dedications;Diagnosis;Diagnostic;Direct Costs;Dissemination and Implementation;effectiveness/implementation trial;endotracheal;Engineering;Environment;Evaluation;evidence base;Evidence based practice;experience;Faculty;Florida;Focus Groups;Fright;Future;Goals;Growth;Health Care Costs;healthcare-associated infections;Hospital Charges;hospital readmission;Hospitalization;Hospitals;Human;implementation barriers;implementation science;implementation strategy;improved;improved outcome;Infection;Institution;Interdisciplinary Study;interest;International;Interruption;Intervention;Interview;K-Series Research Career Programs;Length of Stay;Lung;Measures;Mechanical ventilation;medical schools;Medicine;member;Mentors;Microbiology;Modeling;Modification;Morbidity - disease rate;mortality;Outcome;patient oriented research;patient safety;Patients;Pediatric Hospitals;Pediatric Intensive Care Units;Perception;pragmatic implementation;Preparation;Prevention;Process;process improvement;programs;Provider;public health relevance;Qualitative Methods;Qualitative Research;Quality of Care;Readiness;Reproducibility;Research;research and development;Research Methodology;Research Personnel;Resources;respiratory;respiratory colonization;Respiratory System;Respiratory Tract Infections;Risk;Safety;Sepsis;Septic Shock;Series;skills;success;support tools;Surveys;Time;tool;Training;Uncertainty;Universities;Variant;ventilation;Ventilator;Work

PROJECT_TITLE: Optimizing Respiratory Culture Practices for Mechanically Ventilated Children

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: PROJECT NARRATIVE Glioblastoma is an incurable primary brain tumor that is characterized by regions of hypoxia and is highly resistant to radiation. This work will reveal a novel mechanism by which hypoxia regulates a lncRNA to promote glioblastoma progression. If successful, the findings of this study will provide new strategies to improve treatment for glioblastoma.

PI_NAMEs: YU, JENNIFER S (contact);ZHAO, JIANJUN

PROJECT_TERMS: Animals;Area;Binding;Biological Assay;Brain Neoplasms;Cell Maintenance;Cell Nucleus;Cells;chemotherapeutic agent;Chromatin;chromatin isolation by RNA purification sequencing;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR interference;cytotoxic;Data;design;digital;Epigenetic Process;epigenetic regulation;Gene Expression Regulation;Genes;genetic manipulation;Genetic Transcription;genomic locus;Glioblastoma;Glioma;Goals;Growth;HIF1A gene;Human;Hypoxia;hypoxia inducible factor 1;improved;in vivo;Individual;knock-down;Knowledge;Left;leukemia;lung cancer cell;Lung Diseases;Maintenance;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Modeling;mouse model;nano-string;normoxia;novel;novel therapeutic intervention;Nuclear;Organoids;overexpression;Pathway interactions;patient response;Patients;Penetration;Play;Primary Brain Neoplasms;Prognosis;promoter;Proteins;Pulmonary Emphysema;Radiation;Radiation Oncologist;radiation response;radioresistant;recruit;Recurrent disease;Recurrent tumor;Refractory;Regulation;Renal Cell Carcinoma;Resistance;response;Response Elements;Ribonucleoproteins;RNA purification;Role;self-renewal;Signal Transduction;Smoking;stem cells;stem-like cell;stemness;therapeutic target;therapy resistant;Transactivation;transcriptome;transcriptome sequencing;treatment strategy;tumor;tumor growth;tumor progression;Tumor Promotion;tumorigenesis;Untranslated RNA;Work;Xenograft procedure

PROJECT_TITLE: lncRNA regulation of glioblastoma progression and therapeutic resistance

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


PROJECT_TERMS: Acceleration;Address;advanced analytics;Algorithms;Area;Automobile Driving;Bathing;bioimaging;Biological;Biological Models;Biological Process;biological research;Biology;Biomedical Research;Brightfield Microscopy;catalyst;Cells;Cellular biology;Cellular Structures;Chromatin Structure;Collaborations;college;Communities;Computational Technique;computer scientist;Computer software;Cultured Cells;Data Analyses;deep learning;Development;Dimensions;Disease;Educational Materials;Educational process of instructing;empowerment;Ensure;Event;experimental study;Face;Feedback;Fluorescence;Geographic Locations;Goals;Hand;human tissue;Image;Image Analysis;image processing;imaging modality;improved;Individual;innovation;Institution;International;Laboratories;light microscopy;Measures;Methods;microscopic imaging;Microscopy;Mission;Modality;Modernization;next generation;novel;open source;Organism;Organoids;Paper;Publishing;quantitative imaging;Reproducibility;Research;research and development;Research Personnel;Resource Sharing;Resources;Role;Side;skills;software development;Software Engineering;Technology;technology research and development;Tissues;tool;Training;Translating;Universities;usability;user friendly software;user-friendly;Wisconsin;Work;Writing


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dietary Supplements;Genetics;Human Genome;Neurosciences;Nutrition;Pediatric;Prevention;Rare Diseases;Spina Bifida

PI_NAMEs: NISWANDER, LEE A. (contact)

PROJECT_TERMS: 22q11.2;Actins;Alleles;Biological;Cell Proliferation;cell type;Cells;Cephalic;Chromatin;Cilia;cilium biogenesis;Collection;Complement;Congenital Abnormality;Data;de novo mutation;Development;Diet;Diet Modification;DNA Methylation;Ectoderm;Embryo;Environmental Impact;Environmental Risk Factor;Epigenetic Process;epigenome;Ethylnitrosourea;Failure;Folic Acid;Folic acid fortification;folic acid metabolism;folic acid supplementation;gene environment interaction;Gene Expression;gene function;gene interaction;Gene Mutation;Genes;Genetic;genetic testing;Genetic Transcription;Genome;Goals;Grain;Head;Heterozygote;Human;human model;imaging platform;Individual;insight;Knock-in;Knockout Mice;Link;live cell imaging;Mammals;Mediating;Meningomyelocele;Mesoderm;Methylation;methylome;Modeling;Molecular;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutate;Mutation;nerve stem cell;neural plate;Neural tube;Neural Tube Closure;Neural Tube Defects;novel;Nucleotide Biosynthesis;offspring;Pathway interactions;Patients;Pattern;Penetrance;Phenocopy;Phenotype;planar cell polarity;Point Mutation;Process;Program Research Project Grants;programs;Proteins;Regulation;response;Risk;Risk Factors;Risk Reduction;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;SHH gene;Signal Transduction;smoothened signaling pathway;Standard Model;Testing;Time;Tissues;transcriptome;Transforming Growth Factor beta;Tube;Variant;WNT Signaling Pathway;Work

PROJECT_TITLE: Project III - Modeling meningomyelocele alleles and response to folic acid diet in mouse


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Prevention

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE: The broad, long-term objective of our research is to improve the health of the nearly 1 million Americans with advanced liver disease (cirrhosis). One of the most important complications of cirrhosis is the development of enlarged, fragile blood vessels in the wall of the lower esophagus, which can rupture without warning, leading to life-threatening bleeding. We aim to develop non-invasive MRI methods that can detect this complication before bleeding occurs, to facilitate preventative treatment that can reduce cirrhosis-associated mortality.

PI_NAMEs: REEDER, SCOTT B. (contact);WIEBEN, OLIVER

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: 3-Dimensional;3D Print;4D MRI;Acceleration;Address;Adult;American;Anatomy;Anesthesia procedures;Biological;Biological Markers;biomarker validation;Blood;Blood flow;blood flow measurement;Blood Platelets;Blood Vessels;Caring;Catheters;Circulation;Cirrhosis;Clinical;Clinical Management;Clinical Practice Guideline;clinically relevant;Complex;Complication;Data;design;Detection;Development;Diagnostic;diagnostic accuracy;Diagnostic tests;Early identification;end stage liver disease;Esophagogastroduodenoscopy;Esophagus;follow-up;Future;gastric vein;Gastroenterologist;Goals;Guidelines;Health;hemodynamics;Hemorrhage;Hepatic;Hepatology;high risk;improved;innovation;Intervention;Left;Length;Life;Ligation;Liver;Liver diseases;liver stiffness;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;Mission;Monitor;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Invasive Detection;novel;Patient Triage;Patients;Performance;Portal Hypertension;Portal Pressure;pre-clinical;predictive marker;prevent;Preventive treatment;Procedures;prophylactic;Prophylactic treatment;Radial;Recommendation;Reference Standards;Reproducibility;Research;Resistance;response;Risk;risk stratification;Rupture;Sedation procedure;Sensitivity and Specificity;Serum;Severities;Shunt Device;Societies;specific biomarkers;Specificity;Spleen;Submucosa;Surface;Testing;Therapeutic;Time;Translating;Translations;ultrasound;Validation;validation studies;Varicosity;vector;Venous;Venous Pressure level;Visualization;Work

PROJECT_TITLE: Development of 4D Flow MRI for Risk Stratification of Variceal Bleeding in Cirrhosis


ORG_CITY: Loma Linda

ORG_NAME: LOMA LINDA UNIVERSITY

PHR: NARRATIVE  Aneurysmal  subarachnoid  hemorrhage  (SAH),  which  occurs  due  to  rupture  of  an  intracranial  aneurysm,  is  a  devastating  disease  associated  with  high  fatality  and  long- term  morbidity  among  survivors.  This  proposal  will  elucidate  the  neurovascular  protective  effects  of  pigment  epithelium- derived  factor  (PEDF),  a  secreted  pluripotent glycoprotein, against early brain injury after SAH. The protective effects of PEDF mediated via PEDF  receptor  (PEDF- R)  signaling  pathways against  neuronal apoptosis  and blood  brain barrier  disruption  following  SAH will be elucidated.

PI_NAMEs: ZHANG, JOHN H (contact)

PROGRAM_OFFICER_NAME: KOENIG, JAMES I

PROJECT_TERMS: Acute;Affinity;Age;Aneurysmal Subarachnoid Hemorrhages;Apoptosis;Apoptotic;Attenuated;Binding;Blood - brain barrier anatomy;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;Brain Edema;Brain hemorrhage;Brain Injuries;Cardiac Myocytes;Cell Death;Cell Survival;cell type;cerebral ischemic injury;Cerebrovascular Spasm;Clinical;clinical translation;Data;Deterioration;Disease;Event;Gene Family;Glycoproteins;Goals;granule cell;Homeostasis;human fetal retinal pigment epithelial cell;improved;improved outcome;In Vitro;Inflammatory;Injury;insight;Intracranial Aneurysm;Intracranial Hypertension;Intranasal Administration;Ischemia;knock-down;Link;Lipase;macular edema;Maintenance;Malignant - descriptor;Mediating;Membrane;Modeling;Molecular;Morbidity - disease rate;mortality;Nervous System Physiology;neurobehavior;Neurologic;neuron apoptosis;Neurons;neurovascular;new therapeutic target;novel;Osteoblasts;Outcome;overexpression;Pathology;Pathway interactions;Patients;Perforation;pigment epithelium-derived factor;pigment epithelium-derived factor receptor;protective effect;protective efficacy;protective pathway;protein expression;Rattus;Recombinants;Research;Rodent;Rodent Model;Role;Rupture;Serine Proteinase Inhibitors;sex;Signal Pathway;Stroke;Subarachnoid Hemorrhage;Survivors;Therapeutic;therapeutic target;Tissues;transcription factor;Transient Cerebral Ischemia;treatment strategy;Vascular Permeabilities

PROJECT_TITLE: Novel neurovascular protective mechanisms of PEDF after subarachnoid hemorrhage

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


PROJECT_TERMS: Acceleration;Address;advanced analytics;Algorithms;Area;Automobile Driving;bioimaging;Biological;Biological Models;Biological Process;biological research;Biology;Biomedical Research;catalyst;Cells;Cellular biology;Collaborations;Communities;community engagement;Computational Technique;computer scientist;Computer software;deep learning;deep learning model;Development;Dimensions;Disease;Education;Educational workshop;empowerment;Ensure;Event;experimental study;Feedback;Friends;Future;hackathon;Hour;Image;Image Analysis;image processing;imaging modality;imaging software;improved;Infrastructure;innovation;International;Laboratories;light microscopy;Measures;Methods;microscopic imaging;Microscopy;Mission;Modality;next generation;novel;open source;Organism;Paper;Persons;quantitative imaging;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;Role;Route;Services;Shapes;Side;skills;Software Engineering;symposium;Technology;technology research and development;technology training;Tissues;tool;Training;Translating;Universities;usability;user friendly software;user-friendly;Wisconsin;Work


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: ANT2 in Metaflammation And Insulin Resistance PROJECT NARRATIVE/ABSTRACT Adenine nucleotide translocase (ANT)-2 is a mitochondrial protein that mediates mitochondrial remodeling in adipocytes and hepatocytes to drive insulin resistance and hepatosteatosis in obesity. Our preliminary data suggest that ANT2 acts as a free fatty acid sensor in macrophages and induces cell type-specific mitochondrial remodeling to drive proinflammatory activation of adipose tissue macrophages, leading to metaflammation and insulin resistance in obesity. If successful, our study will provide a novel mechanism for how obesity confers metaflammation and insulin resistance.

PI_NAMEs: LEE, YUN SOK  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Adenine Nucleotide Translocase;Adipocytes;Adipose tissue;Anti-diabetic Drugs;Anti-Inflammatory Agents;Automobile Driving;Biology;cell type;Chronic;Clinical;Cues;Data;Diabetes Mellitus;Electron Transport;Epidemic;Etiology;Exhibits;exosome;extracellular;Fatty Liver;flexibility;Functional disorder;Gene Expression;Glucose Intolerance;Glucose Metabolism Disorders;Growth;Hepatocyte;Immune;improved;Inflammation;Inflammatory;Inner mitochondrial membrane;Insulin Resistance;insulin sensitivity;insulin signaling;Knock-out;Knockout Mice;Macrophage;Macrophage Activation;Maintenance;Measures;Mediating;Medical;Membrane Proteins;Metabolic;Metabolism;MicroRNAs;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Molecular;monocyte;Morbidity - disease rate;mortality;mouse development;Muscle Cells;Myelogenous;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;Nonesterified Fatty Acids;novel;Nutritional;Obese Mice;Obesity;obesity development;Patients;Phagocytosis;Phenotype;Plasma;Play;Prevalence;prevent;Prevention;Process;Production;Reactive Oxygen Species;Regulation;Reporting;Respiration;response;Role;sensor;side effect;Signal Transduction;Source;System;Testing;Therapeutic;Thiazolidinediones;Tissues;trafficking

PROJECT_TITLE: ANT2 in metaflammation and insulin resistance

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Lung;Lung Cancer;Rare Diseases;Skin Cancer

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE We discovered that germline BAP1 mutations are associated with high susceptibility to multiple tumor types: among them the prevalence of malignant mesothelioma (MM) predominates upon exposure to low amounts of asbestos that do not normally cause disease. Here we propose to determine the mechanisms by which BAP1 mutations modulate cancer penetrance in carriers of germline BAP1 mutations including the effects of BAP1 on cellular metabolism and how these mechanisms relate to cancer penetrance and mesothelioma.

PI_NAMEs: CARBONE, MICHELE  (contact);YANG, HAINING

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Address;aerobic glycolysis;Affect;Age;Alleles;Apoptosis;Asbestos;Binding;Calcium;Calcium Channel;Calcium Signaling;cancer cell;cancer type;carcinogenesis;carcinogenicity;Carcinogens;Cell Culture Techniques;Cell Death;Cell Differentiation process;Cell Nucleus;Cell Survival;cell transformation;Cells;Cessation of life;Citric Acid Cycle;cohort;Collaborations;Complement;Cutaneous Melanoma;Cytoplasm;Cytosol;Data;Development;Disease;DNA;DNA Damage;DNA Repair;Dose;Endoplasmic Reticulum;Environment;environmental carcinogenesis;Environmental Carcinogens;Enzymes;erionite;Exposure to;Family;Family member;General Population;Genes;Genetic;Genetic Transcription;Germ Lines;Germ-Line Mutation;Growth;Heterozygote;High Prevalence;HMGB1 gene;Human;Hypoxia;Impairment;in vivo;Incidence;Individual;Induced Mutation;Inherited;inorganic phosphate;Inositol;ionization;irradiation;Lead;Link;Malignant - descriptor;Malignant mesothelioma;Malignant Neoplasms;Melanoma;Mesothelioma;Metabolic;Metabolic Pathway;Metabolism;metaplastic cell transformation;Mineral Fibers;Mitochondria;mitochondrial metabolism;mouse model;Multiprotein Complexes;Mus;Mutate;Mutation;mutation carrier;Names;Nature;novel;Nuclear;Pathogenesis;Pathway interactions;Penetrance;Phenotype;Plasma;Predisposition;Prevalence;Primary Cell Cultures;Proliferating;Reagent;receptor;Regulation;Resistance;response;Risk;Role;Sarcoma;sex;Skin Cancer;Skin Carcinoma;Somatic Mutation;stem;Syndrome;synergism;Testing;Therapeutic Intervention;Time;tripolyphosphate;tumor;tumor growth;Tumor Promotion;Ultraviolet Rays;uptake;UV induced;Uveal Melanoma;volunteer;Warburg Effect;Wild Type Mouse

PROJECT_TITLE: Mechanisms of BAP1 activity in human cancer development

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Nanotechnology;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Our proposed work will develop the targeted delivery of multimodal therapy for reducing racial disparities of African American prostate cancer. Our proposed study will move beyond an incremental advance, accelerate the development of new therapeutics against metastatic prostate cancer, and improve clinical outcomes in African American patients with prostate cancer.

PI_NAMEs: LIU, RUNHUA RUNA (contact);ZHOU, JIANGBING

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Ablation;Acceleration;advanced prostate cancer;African American;African American population;American;androgen independent prostate cancer;Antibodies;antibody conjugate;Biology;Cancer Biology;Cancer Etiology;cancer health disparity;cancer immunotherapy;Cancer Patient;cancer type;Cell Communication;Cell Line;Cell membrane;Cell model;Cells;Cessation of life;Clinical;Combined Modality Therapy;Data;Data Set;Death Rate;Development;Diagnosis;Disease;Ectopic Expression;effective therapy;Epithelial Cells;European;Exhibits;Genes;Genetic;Glycolates;Goals;GPI Membrane Anchors;high risk;Human;Immune;Immune Evasion;Immune response;Immunosuppressive Agents;improved;improved outcome;in vivo;inducible gene expression;Inflammatory;innate immune checkpoint;knock-down;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Membrane Glycoproteins;men;Messenger RNA;Metastatic Prostate Cancer;Molecular;Monoclonal Antibodies;mouse model;Mus;mutant;Mutation;nanoparticle;nanopolymer;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel therapeutics;Oncogenes;Oncogenic;Outcome;overexpression;Oxidation-Reduction;palliative;Patients;Phagocytosis;Pharmaceutical Preparations;Polymers;Prognosis;Prostate;prostate cancer cell;prostate cancer metastasis;racial disparity;racial population;Repression;Resources;Role;Sampling;sialic acid binding Ig-like lectin;small molecule;systemic toxicity;targeted delivery;targeted treatment;Testing;Therapeutic;therapeutic target;TP53 gene;treatment strategy;tumor;Tumor-associated macrophages;United States;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeted delivery of multimodal therapy for reducing prostate cancer disparity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Among the fifty states, New Hampshire ranks number one in the incidence of breast, esophageal, and urinary bladder cancers, the latter reflecting the association between bladder cancer and environmental arsenic exposure linked to frequent use of rural well water within the “Granite State”. Of similar concern, Vermont ranks number one in the incidence of uterine cancer and second in the incidence of melanoma. Norris Cotton Cancer Center continues to create important new knowledge, engage our community, and influence public policy related to these and other cancers in a manner directly relevant to these unique catchment area public health needs.

PI_NAMEs: LEACH, STEVEN D (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Acceleration;Adopted;anti-cancer research;Area;Arsenic;Authorship;Biological;Breast;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer immunotherapy;cancer prevention;career;Caring;Catchment Area;Characteristics;Clinic;Clinical;Clinical Trials;college;Communities;Community Outreach;Continuity of Patient Care;design;Development;Education;Education and Outreach;Engineering;Entrepreneurship;Esophagus;Evaluation;experience;Faculty Recruitment;faculty research;Frequencies;Funding;Genomics;granite;Growth;health care delivery;health equity promotion;Health system;Immunology;Immunooncology;Incidence;innovation;Institution;interdisciplinary collaboration;Investigational Therapies;investigator-initiated trial;Investments;Knowledge;Lead;Leadership;Link;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Medical;medical schools;Melanoma;member;Mission;Molecular Epidemiology;New Hampshire;Norris Cotton Cancer Center;novel;Parents;Pathology;Patients;Phase;Population;Population Heterogeneity;Population Sciences;precision oncology;prevent;Prevention;programs;Public Health;Public Policy;Publications;Research;Research Infrastructure;Research Support;Research Training;Resource Sharing;Rural;Rural Population;Schools;Science;Site;Strategic Planning;survivorship;Therapeutic;Trace Elements;Translating;Translational Research;tumor immunology;United States National Institutes of Health;Update;Uterine Cancer;Vermont;well water

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: NARRATIVE Glioblastoma is the most aggressive and deadly form of brain cancer whose poor clinical outcome stems from its diffuse invasion throughout the brain and drug resistance. This project will develop and thoroughly characterize a tissue engineering platform to investigate pathophysiological processes responsible for invasive spreading, therapeutic resistance, and poor survival.

PI_NAMEs: HARLEY, BRENDAN A. (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: Acceleration;Address;Alkylating Agents;Animal Model;Animals;anti-cancer;Automobile Driving;Behavior;Benchmarking;Biocompatible Materials;bioinformatics tool;Biological Assay;Biophysics;Blood Vessels;Brain;Brain Neoplasms;Cancer Model;Cell Line;Cells;Clinic;Clinical;detection limit;Diffuse;Dimensions;Disparate;DNA;DNA Modification Process;DNA Repair;drug candidate;Drug resistance;Engineering;Evaluation;Excision;Failure;Gelatin;Generations;Glioblastoma;Glioma;Goals;High-dimensional Modeling;Human;Hyaluronic Acid;Hydrogels;Imaging Device;in vivo;in vivo evaluation;insight;Invaded;Libraries;Link;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Meta-Analysis;Metabolic;Methyltransferase;Microfluidics;migration;mimetics;miniaturize;Modeling;Molecular Weight;mortality;neurovascular;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Patients;Pattern;Pericytes;Physiological;Play;pressure;Process;programs;Proliferating;Proteins;Recurrence;repaired;Resistance;Resources;response;Role;Signal Transduction;Specimen;standard of care;stem;Surgical margins;Survival Rate;Technology;temozolomide;therapeutic evaluation;therapy resistant;Tissue Engineering;Tissue Model;tumor;Variant;Work;Xenograft procedure

PROJECT_TITLE: Perivascular tissue models to overcome MGMT-mediated temozolomide resistance in glioblastoma

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: GERLACH, ROBERT W (contact)

PROJECT_TERMS: Adopted;American Cancer Society;Applications Grants;Award;Basic Science;Budgets;Calendar;Cancer Center;Cancer Center Support Grant;Capital;career;Center Core Grants;Charge;Clinical Oncology;Clinical Trials;Collaborations;college;Communication;Communities;community engagement;Community Outreach;Data;Decision Making;Development;equipment acquisition;experience;Faculty;Faculty Recruitment;Funding;graduate school;Grant;Health system;implementation efforts;Individual;Institution;inter-institutional;Investments;Lead;Leadership;Maintenance;Malignant Neoplasms;medical schools;member;Norris Cotton Cancer Center;Oncology Group;Parents;Performance;Pilot Projects;Population Sciences;Positioning Attribute;Preparation;Principal Investigator;Process;programs;Progress Reports;recruit;Reference Document;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;Secure;Services;Specific qualifier value;Strategic Planning;System;The Jackson Laboratory;Time;Translational Research;United States National Institutes of Health;Update;Vision;web site;Work

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Services;Radiation Oncology

PI_NAMEs: BERWIN, BRENT L (contact)

PROJECT_TERMS: Address;American Cancer Society;anti-cancer research;Area;Award;Awareness;base;Businesses;cancer care;Cancer Center Support Grant;cancer therapy;career;career development;Caring;Centers of Research Excellence;Clinical;clinical practice;clinical translation;Collaborations;college;community partnership;curriculum development;Dedications;Development;disadvantaged background;Education;education resources;Educational process of instructing;Eligibility Determination;Engineering;Evaluation;experience;Exposure to;Faculty;Fostering;Foundations;Funding;Future;Generations;Goals;Grant;Health;Health system;Healthcare Systems;Honduras;improved;innovation;Institution;Joints;K-Series Research Career Programs;Knowledge;Leadership;Learning;Link;Malignant Neoplasms;Medical;Medical Residency;medical schools;Medical Students;member;Mentors;minority undergraduate;Mission;next generation;Norris Cotton Cancer Center;novel;Oncology;Operative Surgical Procedures;Physicians;Positioning Attribute;Prevention;Program Development;programs;Provider;Radiation Oncology;Radiation Physics;Reporting;Research;Research Personnel;Research Training;Residencies;Resources;Rwanda;Scholars Program;Schools;Science;Scientist;Students;teacher;Time;Training;Training and Education;Training Programs;translational medicine;translational oncology;translational physician;Translational Research;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Vision;Writing

PROJECT_TITLE: Cancer Research Career Enhancement


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Nanotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Women's Health Research

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative The proposed research is relevant to public health because it probes differential pathological response to traumatic brain injury based on sex and subsequent implications for neurotherapeutic interventions. This project is relevant to NIH’s mission as it focuses on biological considerations for improving treatment of traumatic brain injury, the leading cause of injury related death in America.

PI_NAMEs: SIRIANNI, RACHAEL W;STABENFELDT, SARAH E (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Address;Aging;Artificial nanoparticles;Bacteriophages;Bioinformatics;Biological;biological sex;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;Brain Injuries;brain parenchyma;Cancer Model;candidate validation;Cells;Central Nervous System;central nervous system injury;Clinical Pharmacology;Complex;controlled cortical impact;Cytometry;Data;Deposition;design;digital;Disease;Drug Delivery Systems;drug distribution;Drug Kinetics;Drug Targeting;Economic Burden;Encapsulated;Environment;Estrogens;ethylene glycol;Event;experience;Female;Functional disorder;Goals;Gonadal Steroid Hormones;Histone Deacetylase Inhibitor;Histones;Hormonal;Hormones;Hour;Immune;improved;improved outcome;in vivo;Inflammation;Inflammatory;inhibitor;injured;Injury;injury-related death;innovation;Intervention;intravenous administration;intravital imaging;Label;Ligands;Loperamide;male;Mediating;Memory;Mission;mouse model;Mus;nanomedicine;nanoparticle;nanoparticle delivery;nanoparticle drug;Nervous System Trauma;neuroinflammation;neuroprotection;next generation;next generation sequencing;novel;Outcome;Ovariectomy;Pathologic;Pathology;Patient-Focused Outcomes;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Phase III Clinical Trials;poly(lactic acid);pre-clinical;Proestrus;Progesterone;Public Health;Publishing;Research;response;response to brain injury;response to injury;Role;sex;Sex Differences;Shapes;side effect;Stroke;Subarachnoid Hemorrhage;System;targeted treatment;TBI treatment;Testing;Therapeutic;therapeutic nanoparticles;Tight Junctions;Time;Tissues;transcriptome sequencing;Translating;Traumatic Brain Injury;Treatment Efficacy;two photon microscopy;United States National Institutes of Health;water channel;women versus men;Women's Health;Work

PROJECT_TITLE: Exploiting sex-dependent brain injury response for nanoparticle therapeutics


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative: Despite significant advances in the prevention and treatment of CRC in the United States (1 of the top 3 cancer types in the U.S), there remains a need for new approaches and molecular targets to markedly reduce morbidity due to this disease. This proposal focuses on the use of a novel, selective compound that can repress the activity of a nuclear receptor, the peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) for this purpose. The proposed studies will have high translational impact to fight this prevalent disease using selective modulation of PPARβ/δ transcriptional activity as a mechanism to prevent/treat CRC progression and may provide a new target for combinatorial strategies to effectively treat and/or prevent recurrence of this disease.

PI_NAMEs: PATTERSON, ANDREW ;PETERS, JEFFREY M (contact)

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: Acute;anti-cancer;Antineoplastic Agents;APC gene;Bioinformatics;Biological Markers;Breast Cancer Model;cancer cell;Cancer cell line;cancer heterogeneity;Cancer Model;cancer prevention;cancer therapy;cancer type;Cells;Colon;colon cancer patients;colon cancer prevention;Colon Carcinoma;Colorectal Cancer;colorectal cancer prevention;colorectal cancer progression;colorectal cancer treatment;combinatorial;Complex;constitutive expression;Coupled;Data;Databases;Disease;Disputes;Dose;dosimetry;Down-Regulation;drug efficacy;Drug Kinetics;Drug resistance;Drug Targeting;effective therapy;efficacy evaluation;Epithelium;Evaluation;Event;Exhibits;Feces;fighting;gain of function;Gene Expression;gene repression;Genes;Genetic;genetic corepressor;Genetic Transcription;Genomics;Genotype;Goals;Growth Factor Receptors;Histology;Human;Immune checkpoint inhibitor;improved;inhibitor;innovation;insight;Invaded;KRAS2 gene;Ligands;Link;loss of function;Malignant Neoplasms;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methodology;migration;Modeling;Molecular;Molecular Target;Morbidity - disease rate;Mutation;Mutation Spectra;Neoplasm Metastasis;Nodal;novel;novel marker;novel strategies;NU/NU Mouse;Nuclear Receptors;overexpression;Pathway interactions;Peroxisome Proliferator-Activated Receptors;personalized approach;Pharmaceutical Preparations;Phase;PPAR-beta;Pre-Clinical Model;prevent;Prevention;Proto-Oncogenes;receptor;recruit;Recurrence;Recurrent disease;refractory cancer;Regulation;Repression;Research;Resistance;Role;Scientist;stemness;Study models;Systems Analysis;Testing;Therapeutic;Time;Tissues;Toxic effect;TP53 gene;transcription factor;translational impact;Translational Research;tumor;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;United States;Variant;web platform

PROJECT_TITLE: Unique targeting of PPARβ/δ regulation for cancer prevention and therapy

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: TOSTESON, TOR D (contact)

PROJECT_TERMS: Administrative Efficiency;anti-cancer research;Applications Grants;Award;Behavioral Research;Bioinformatics;bioinformatics resource;Bioinformatics Shared Resource;biomedical data science;Biometry;Biotechnology;Budgets;Cancer Biology;Cancer Center Support Grant;Cancer Detection;Client;Clinic;Clinical Cancer Center;Clinical Protocols;Clinical Research;Clinical Trials Design;Collaborations;Comparative Effectiveness Research;computer cluster;Computer software;Computer Systems;Consult;Consultations;Data;Data Analyses;data management;data mining;Databases;design;Development;Education;Engineering;experience;Faculty;Funding;Gene set enrichment analysis;Genetic;genomic data;Genomics;Goals;High Performance Computing;Home;image processing;Individual;Information Systems;Institution;Machine Learning;Malignant Neoplasms;Manuscripts;medical specialties;member;Mentors;Methodology;Monitor;Norris Cotton Cancer Center;novel;parallel computer;Pathway Analysis;Pathway interactions;Pediatrics;Peer Review;Population Sciences;programs;protocol development;Protocols documentation;Publications;Quality of life;Randomized;Reporting;Research Design;Research Personnel;Research Proposals;Research Support;Resource Informatics;Resource Sharing;Resources;response;Safety;Sample Size;Science;Services;Site;sound;Statistical Methods;Statistical Study;Terminal Disease;Therapeutic;Time;tool;Translational Research;United States National Institutes of Health;Walking

PROJECT_TITLE: Biostatistics and Bioinformatics (BBSR)


PI_NAMEs: LEWIS, LIONEL DAVID (contact)

PROJECT_TERMS: Biological Assay;Budgets;Cancer Center Support Grant;Cells;Clinical;Clinical Cancer Center;Clinical Oncology;Clinical Pharmacology;Clinical Research;clinical translation;Concentration measurement;Consultations;cost;Data Analyses;data modeling;design;detection method;Development;DNA;Drug Combinations;Drug Kinetics;Epidemiology;epidemiology study;Faculty;Fluorescence;Funding;High Pressure Liquid Chromatography;in vivo;Investigation;Investigational Drugs;Investigational New Drug Application;Investigational Therapies;liquid chromatography mass spectrometry;Malignant Neoplasms;member;Molecular;Norris Cotton Cancer Center;novel;Oncology;operation;Performance;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmaceutical Services;Pharmacists;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Pharmacology Shared Resource;Pharmacy facility;Phase;Plasma;pre-clinical;Pre-Clinical Model;preclinical study;programs;Protocols documentation;Research;Research Assistant;Research Design;Research Methodology;Research Personnel;Saliva;Sampling;Services;Site;Testing;Therapeutic;Therapeutic Studies;Translations;Tumor Tissue;ultraviolet;Urine

PROJECT_TITLE: Clinical Pharmacology (CP)


PI_NAMEs: TOMLINSON, CRAIG R (contact)

PROJECT_TERMS: 3-Dimensional;absorption;Antigens;ATAC-seq;Bar Codes;Bioinformatics;Bioinformatics Shared Resource;Biological Assay;Biology;Biomedical Research;Biometry;Budgets;Cancer Center;Cancer Center Support Grant;Cell Culture Techniques;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromium;CLIA certified;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;college;Communication;Communities;Complement;congenic;Core Facility;cost effective;cost effective measures;Data;Data Analyses;design;Detection;Dideoxy Chain Termination DNA Sequencing;digital;DNA;DNA Sequence;DNA Sequence Alteration;DNA sequencing;Ensure;epigenomic profiling;exome;experience;experimental study;Fee-for-Service Plans;Funding;Future;Gene Expression Profiling;Genome;genome-wide;Genome-wide Unbiased Identification of DSBs Enabled by sequencing;genomic data;Genomics;Genotype;Human Resources;improved;Institution;instrument;instrumentation;Investigation;Investments;Knock-in;Knock-out;Laboratories;laboratory experience;Leadership;Marketing;Measurement;member;Messenger RNA;Methodology;Microarray Analysis;MicroRNAs;Mission;Molecular Biology;Molecular Biology Shared Resource;Monitor;Mus;nano-string;new technology;Norris Cotton Cancer Center;Pathology;Patient-Focused Outcomes;Performance;Pilot Projects;prevent;Procedures;programs;Protein Analysis;protein profiling;Proteins;Proteomics;Protocols documentation;Quality Control;Radar;Reagent;recruit;Reproducibility;Research;research facility;Research Personnel;Resource Sharing;Resources;RNA;Running;Sampling;service providers;Services;single cell genomics;single cell sequencing;SNP genotyping;Speed;success;symposium;System;targeted sequencing;Technology;technology development;Time;tool;transcriptome;transcriptome sequencing;translational impact;translational medicine;whole genome;Work

PROJECT_TITLE: Genomic and Molecular Biology (GMB)


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Postsynaptic Signaling by Norepinephrine and cAMP Project Narrative This project is to investigate the molecular basis of regulation of glutamatergic synaptic transmission by norepinephrine (NE), which increases our alertness and cognitive functions. Specifically, we will explore whether NE can be taken up by neurons to augment via paradigm-shifting intracellular signaling the phosphorylation of glutamate receptors (AMPARs) and thereby their postsynaptic accumulation and synaptic strength. We will characterize activation of the Ca2+ channel CaV1.2 upon stimulation of AMPAR activity by NE at postsynaptic sites, with CaV1.2 and AMPARs being major targets for NE in the brain. Aberrant functioning of NE signaling, of glutamate receptors, and of CaV1.2 are implicated in neurological and mental diseases such as Alzheimer’s disease, posttraumatic stress disorder, schizophrenia, and ADHD. Defining new molecular aspects of NE signaling will identify important new drug targets for treatment of these diseases. Page 1

PI_NAMEs: HELL, JOHANNES W (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acute;Adenylate Cyclase;Adrenergic Receptor;Affect;Agonist;alertness;Alzheimer's Disease;Arousal;Attention;Attention deficit hyperactivity disorder;Binding;Binding Sites;Biological Assay;Brain;Cell membrane;Cell surface;Cells;Co-Immunoprecipitations;cognitive function;Complex;Cyclic AMP;Cyclic AMP Receptors;Cyclic AMP-Dependent Protein Kinases;Cytosol;Data;Dendritic Spines;density;Diffuse;Disease;DLG4 gene;Drug Targeting;Endoplasmic Reticulum;endosome lumen;Endosomes;Ensure;Fostering;Glutamate Receptor;Glutamates;Goals;Hippocampus;Image;Individual;inhibitor;Injections;Isoproterenol;knock-down;Learning;Link;Mediating;Mediator;Membrane;Memory impairment;Microscopy;Modeling;Molecular;Monitor;monoamine;Mus;Mutation;Nervous System Disorder;Neurologic;Neurons;new therapeutic target;noradrenaline transporter;Norepinephrine;Organic Cation Transporter;Peptides;phosphoric diester hydrolase;Phosphorylation;Play;Point Mutation;polypeptide;Post-Traumatic Stress Disorders;postsynaptic;Probability;protein kinase A kinase;Proteins;Psyche structure;Recycling;Regulation;Reporting;Research;response;Role;Schizophrenia;Science;Signal Transduction;Site;Sleep Deprivation;Slice;Sodium Chloride;Stimulus;Surface;Synapses;synaptic function;Synaptic Membranes;Synaptic Transmission;targeted treatment;Testing;Tetanus;Theta Rhythm;Time;trafficking;Up-Regulation;uptake;Western Blotting;Work

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Cancer;Immunotherapy

PI_NAMEs: CHANNON SMITH, JACQUELINE YVONNE (contact)

PROJECT_TERMS: analysis pipeline;B-Lymphocytes;Biological Assay;Biotechnology;Blood;Budgets;Cancer Center Support Grant;cancer clinical trial;cancer immunotherapy;Cell Separation;Cells;chimeric antigen receptor T cells;Client;Clinical Trials;Collaborations;college;Color;Communities;Conduct Clinical Trials;Consent;Consultations;Cryopreservation;cytokine;Cytometry;Data;Data Analyses;design;Development;Equipment;Excision;Experimental Designs;extracellular;Flow Cytometry;Flow Cytometry Shared Resource;Fluorescence;Frequencies;Funding;Genus Hippocampus;Grant;Guidelines;Human;Immune;Immune checkpoint inhibitor;Immune system;Immunoassay;Immunologic Monitoring;Immunologics;Immunology;improved;Individual;instrument;Laboratories;laboratory experience;Lasers;Leukocytes;Maintenance;Malignant Neoplasms;Measurement;Measures;Melanoma;member;metabolic abnormality assessment;Mission;monocyte;Mus;NCI Center for Cancer Research;Norris Cotton Cancer Center;novel strategies;novel therapeutics;Operative Surgical Procedures;Patients;Peer Review;Performance;Peripheral Blood Mononuclear Cell;Phenotype;programs;Publications;Reader;Recommendation;recruit;repository;Research;Research Personnel;Resource Sharing;Running;Scientist;Services;skills;Skin;Specimen Handling;Stains;Students;success;T-Lymphocyte;Technology;Testing;Time;tissue resident memory T cell;Tissues;TNFRSF5 gene;TNFSF5 gene;Training;Translational Research;Venous blood sampling;Whole Blood

PROJECT_TITLE: Immune Monitoring and Flow Cytometry (IMFC)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Radiation Oncology;Rare Diseases

PI_NAMEs: HOOPES, JACK  (contact)

PROJECT_TERMS: anatomic imaging;angiogenesis;Angiography;animal imaging;Animals;anti-cancer research;Bioluminescence;biomedical imaging;Biotechnology;Brain Neoplasms;Budgets;Cancer Center;Cancer Center Support Grant;cancer surgery;cancer therapy;Cells;cellular imaging;Clinical Research;clinical translation;Communities;Complex;cost effective;Data Analyses;Dedications;Development;Diagnosis;Diagnostic Imaging;dosimetry;driving force;Electron Microscopy;Environment;Equipment;experience;Experimental Designs;Family suidae;Fluorescence Microscopy;Fluoroscopy;Frequencies;Functional Magnetic Resonance Imaging;Funding;Genetic;Head and Neck Cancer;Histopathology;Human;Image;Image Analysis;image visualization;imager;imaging agent;imaging modality;Imaging Techniques;improved;Inflammation;innovation;Institution;instrumentation;irradiation;live cell imaging;Magnetic Resonance Imaging;Maintenance;Malignant Neoplasms;member;Membrane Protein Traffic;Methods;microscopic imaging;Microscopy;Microvascular Permeability;Modality;Modeling;Molecular;Molecular Genetics;Molecular Target;multimodality;NCI Center for Cancer Research;Nerve;new technology;next generation;Norris Cotton Cancer Center;novel;Operative Surgical Procedures;Optics;Pharmacologic Substance;Positron-Emission Tomography;pre-clinical;preclinical imaging;Productivity;programs;Qualifying;Radiation Oncology;radiological imaging;Research;Research Peer Review;Research Personnel;Research Project Grants;Resource Sharing;Resources;Rodent;Scanning Electron Microscopy;Services;Techniques;Technology;Therapeutic;Time;Tissues;tool;Transmission Electron Microscopy;tumor;ultrasound;Update;Whole Organism;Workplace;Xenograft procedure

PROJECT_TITLE: Irradiation, Preclinical Imaging, & Microscopy (IPIM)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The proposed experiments explore the brain circuits that support our seemingly effortless ability to learn and perform sequences of movements with grace and efficiency. Dysfunction in the same brain circuits is thought to cause some of the symptoms seen in common neurologic disorders such as Parkinson’s disease and dystonia. These experiments will elucidate the relationship between normal functions of the basal ganglia and the clinical signs associated with basal ganglia dysfunction.

PI_NAMEs: TURNER, ROBERT STERLING (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Anatomy;Animals;Area;Automobile Driving;Back;Basal Ganglia;Behavior;Behavioral;Bilateral;Brain;Brain region;Cell Nucleus;Clinical;Crystallization;density;Dimensions;Disease;Dystonia;Electrodes;experimental study;Familiarity;flexibility;Functional disorder;Ganglia;Globus Pallidus;Goals;Habits;Human;human disease;Impairment;improved;Individual;Interruption;Lead;Learning;Lesion;Limb structure;Link;Liquid substance;Mediating;Memory;Methods;Monkeys;Motor;motor behavior;Motor Cortex;motor learning;Motor Skills;Movement;Nervous System Disorder;neural;Neurons;nonhuman primate;novel;Output;Parkinson Disease;Pathologic;Performance;pharmacologic;Physiological;Play;preference;prevent;Production;Psychological reinforcement;response;Response to stimulus physiology;Role;Sampling;segregation;sequence learning;Site;skills;Symptoms;Task Performances;Testing;theories;Time;Training;transmission process

PROJECT_TITLE: Motor sequences and basal ganglia-cortical circuits

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]