ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cancer;Contraception/Reproduction;Infertility;Uterine Cancer;Women's Health Research

ORG_CITY: COLUMBIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Project Narrative Resistance to progesterone treatment, via loss of progesterone receptors or their signaling pathways, is a major hurdle in the treatment of endometrial hyperplasia. These studies will contribute to developing fertility- sparing treatments for the preservation of fertility in women of reproductive age with endometrial hyperplasia. These studies will also allow for the development of future PGR/MIG-6 and AKT/mTOR signaling-targeted therapeutic tools to attenuate the expression of genes that lead to progesterone resistance.

PI_NAMEs: KIM, TAE HOON  (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Age;aged;Animal Model;Attenuated;Atypical hyperplasia;Bioinformatics;Biological Markers;cancer therapy;Combined Modality Therapy;comparison control;Complex;conditional knockout;Data;Development;Eligibility Determination;Endometrial;Endometrial Carcinoma;Endometrial Hyperplasia;Endometrial Stromal Cell;Endometrium;Epithelial Cells;Epithelium;Excision;Fertility;fertility preservation;Fertility Rates;FRAP1 gene;Future;Gene Expression;Genes;Genetic Transcription;Goals;Gynecologic;hormone therapy;Human;Hysterectomy;Infertility;inhibitor;insight;Knock-out;Left;Light;Mediating;Mediator;Medicine;Mitogens;Modeling;Molecular;mouse model;mTOR inhibition;Mus;myometrium;new therapeutic target;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;patient response;Patients;Phosphorylation;precision medicine;preservation;prevent;Progesterone;Progesterone Receptors;Proliferating;receptor expression;Receptor Signaling;reproductive;Resistance;response;Role;Signal Pathway;Signal Transduction;success;targeted treatment;Testing;Therapeutic;tool;uterine receptivity;Uterus;Woman;Work;young woman

PROJECT_TITLE: Unravelling mechanisms and novel therapeutic targets for progesterone-resistant endometrial hyperplasia

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Mental Illness;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Orthopedic trauma is common and often associated with profound pain and psychological distress that can persist for years following injury and relate to long-term disability. To promote adaptive recovery, there is an urgent need to elucidate factors that relate to pain and distress following orthopedic trauma and to develop targeted psychological interventions that address these potentially disabling symptoms. This project will take initial steps towards addressing this gap and will lay the groundwork for an independent research program that will harness pain pathophysiology and affective science to promote adaptive recovery following orthopedic trauma.

PI_NAMEs: AARON, RACHEL V. (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Acute;Address;Affective;Aftercare;Amputation;Analgesics;Anxiety;arm;Awareness;Benchmarking;career;career development;central sensitization;chronic pain;chronic pain management;Clinical Research;Clinical Trials;clinically significant;common symptom;Data;Dedications;design;Development;disability;disabling symptom;Distress;Doctor of Philosophy;efficacy evaluation;Eligibility Determination;emotion regulation;Emotional;Emotions;Environment;Event;experience;Faculty;feasibility testing;follow-up;Foundational Skills;Functional disorder;Funding;Goals;Grant;improved;improved outcome;Individual;Injury;Intervention;K-Series Research Career Programs;Laboratories;Lead;Learning;Life;Literature;Long term disability;Measures;Medical;Mental Depression;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentorship;Moods;Multiple Fractures;Nociceptors;novel;Operative Surgical Procedures;Opioid;opioid use;Orthopedics;Pain;pain outcome;pain symptom;participant enrollment;Patient Compliance;Patients;Persistent pain;Persons;Population;post-trauma;Post-Traumatic Stress Disorders;prescription opioid;Process;programs;Prospective cohort;psychologic;psychological distress;Psychologist;Psychology;Recovery;recruit;Rehabilitation therapy;Reporting;Research;research and development;response;Risk;Risk Factors;satisfaction;Science;Sensory;severe injury;Severities;Spinal;success;Surveys;Survivors;Symptoms;Testing;theories;therapy development;Training;Trauma;trauma exposure;Trauma patient;United States;Universities;Work

PROJECT_TITLE: Optimizing pain-related outcomes following orthopedic trauma: testing novel risk factors and determining the feasibility of a new pain psychology intervention

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD(A)-1-K]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Prevention

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: NARRATIVE Early onset colorectal cancer occurs in individuals under age 50 and is an emerging and deadly form of colorectal cancer in the United States. Bacteria and other microbes in the colon are now thought to contribute to causing colorectal cancer. This proposal will seek to define the microbes and mechanisms leading to early onset colorectal cancer so that new ways to detect and prevent this disease can be identified.

PI_NAMEs: SEARS, CYNTHIA  (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Age;Antibiotics;Antibodies;Antibody Response;antibody test;Antigens;Archives;Bacteria;Bacterial Toxins;Bacteriophages;Bacteroides fragilis;Binding;biological adaptation to stress;Biology;cancer diagnosis;cancer surgery;carcinogenicity;Carcinoma;Cessation of life;cohort;Cohort Studies;Colon;colon cancer patients;colon microbiome;colon microbiota;Colonic Neoplasms;Colonic Polyps;Colonoscopy;Colorectal Cancer;colorectal cancer screening;Communities;Complex;Control Groups;Custom;Data;Data Set;design;Diagnosis;Diet;Disease;dysbiosis;early onset colorectal cancer;Ecosystem;Enrollment;Environment;Epidemiology;epigenetic clock;Epithelial Cells;Epithelium;Escherichia coli;Excision;Fluorescent in Situ Hybridization;Fluorescent Probes;Formalin;genome wide methylation;Goals;Hospitals;Human;In Vitro;Incidence;Individual;Inflammaging;insight;Intervention;Libraries;Malignant Neoplasms;Medical;Methylation;Microbe;microbial;Microbial Biofilms;microbial composition;microbiome;microbiota;Molecular;Molecular Profiling;mouse model;Mucous body substance;Mucous Membrane;Nature;Neoplastic Cell Transformation;Neoplastic Epithelial Cell;novel strategies;Obesity;Older Population;Onset of illness;Operative Surgical Procedures;Organism;Paraffin Embedding;Pathogenesis;Patients;Persons;Phage Display;Phage ImmunoPrecipitation Sequencing;Phenotype;polyketide synthase;Polyps;Population;Predisposition;Prevalence;prevent;Prevention;prospective;Prospective cohort;Proteins;Public Health;Recording of previous events;Reporting;Retrospective cohort;Risk Factors;Sampling;screening;Serum;stressor;Structure;Testing;Time;Tissues;trend;Tumor Biology;United States;Viral;whole genome

PROJECT_TITLE: Pathogenesis of Early Onset Colorectal Cancer: Microbiome Contributions and Mechanisms


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Nutrition;Obesity;Pediatric;Prevention;Stimulant Use and Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Public Health Relevance Childhood obesity is a highly prevalent, serious and chronic disease. The cornerstone of obesity treatment, lifestyle therapy, has limited efficacy and durability as a singular intervention and few anti-obesity medications have been examined as an adjunct treatment in this population. This pilot study will examine the preliminary efficacy and feasibility of using lisdexamfetamine, a psychostimulant, as an adjunct to lifestyle therapy for the treatment of childhood obesity.

PI_NAMEs: FOX, CLAUDIA K (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Acute;Adolescence;Adolescent;Adult;Affect;Age;Agonist;Attention deficit hyperactivity disorder;Binge Eating;Binge eating disorder;blood pressure elevation;Body Composition;Body fat;Body mass index;cardiometabolism;Cardiovascular Diseases;Characteristics;Child;Childhood;Chronic Disease;Clinic;Clinical Trials;clinically significant;comorbidity;cost;Data;design;Desire for food;Diet;Disease;Disease Outcome;Dopamine;Dose;Double-Blind Method;Drug Prescriptions;Eating;Eating Behavior;Education;efficacy evaluation;Employment;Energy Intake;Energy Metabolism;executive function;Familiarity;FDA approved;feasibility trial;Financial Hardship;Functional disorder;GLP-I receptor;Goals;Growth;Health;Health behavior;Heart Rate;high risk population;improved;improved outcome;Informal Social Control;Injections;Intervention;Lifestyle Therapy;liraglutide;Malignant Neoplasms;Mental Depression;metabolic rate;Metabolic syndrome;Mission;Morbid Obesity;Morbidity - disease rate;Names;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;Norepinephrine;Obesity;obesity in children;obesity treatment;Obstructive Sleep Apnea;Oral;Participant;pediatrician;Pharmaceutical Preparations;pharmacologic;Phase;phase 3 study;Phentermine;Physical activity;Pilot Projects;pilot trial;Placebo Control;placebo group;Placebos;Play;Population;preadolescence;Premature Mortality;primary endpoint;primary outcome;psychostimulant;Public Health;public health relevance;Quality of life;Randomized;randomized placebo-controlled clinical trial;Randomized, Controlled Trials;Recommendation;Rest;reuptake;reward processing;Rewards;Role;Safety;secondary outcome;sex;social;Societies;Translating;treatment effect;Vyvanse;Weight;Weight Gain;Weight maintenance regimen;Youth

PROJECT_TITLE: Toward Repurposing a Commonly-Used Medication for the Treatment of Pediatric Severe Obesity

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Narrative Disruption of normal development of the visual system leaves lifelong perceptual and cognitive impairments. Understanding the role of cellular and molecular mechanisms responsible for the normal development of vision requires a deep insight into the complex computational tasks our visual system is solving. I aim to achieve such deep insight through 1) making models for solving the task under biological constraints and 2) understanding the theory of tasks under those constraints and 3) proposing novel experiments to validate and solidify the insights from modeling and theory.

PI_NAMEs: TOOSI, TAHEREH  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Adult;Anatomy;Animal Model;Area;area striata;area V1;artificial neural network;Award;Behavioral;Biological;Biological Process;biological systems;Brain;career;Categories;Characteristics;Classification;Code;Collaborations;Complex;Computer Models;Data;Data Analyses;Data Collection;Data Set;design;Development;energy efficiency;Exhibits;experimental study;Eye;Face;Goals;Human;Image;image processing;Impaired cognition;innovation;insight;Knowledge;laboratory experiment;Length;Light;light intensity;Link;machine vision;Maintenance;Maps;Measures;Methods;Modeling;Molecular;Monkeys;Mus;Nervous System;neural;neural network;Neural Network Simulation;Neurons;Noise;novel;object recognition;Ocular Dominance;outcome prediction;Output;Pattern;Performance;Phase;Physiological;Play;Population;Process;Property;Prosthesis;Protocols documentation;receptive field;Resources;response;Retina;retinal prosthesis;Role;sensory input;Series;Shapes;Stimulus;Synapses;Systems Development;Testing;theories;tool;Training;Vision;vision development;Visual;Visual Cortex;visual processing;Visual System;Weight;Work

PROJECT_TITLE: Computational and theoretical understanding of regulatory mechanisms shaping natural vision


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: WASHINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Our lack of knowledge about the level of Env expression during HIV latency prevents effective use of bNAbs as therapeutics. To address this gap, we will (i) measure levels and localization of Env and Gag in latently infected cells in vitro, and (ii) define how different viral subtypes affects HIV protein expression. This high risk, high reward application will lead to future investigations into the relationship between reservoir characteristics such as size, gender, length of infection and protein translation in future studies using cohorts of PLWH.

PI_NAMEs: BOSQUE, ALBERTO ;LYNCH, REBECCA MARIE (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Address;Affect;Antibodies;antibody-dependent cell cytotoxicity;antiretroviral therapy;B-Lymphocytes;Binding;Biological Assay;Cell model;Cell Separation;Cell surface;Cells;Cellular biology;Characteristics;Chronic;Clinical Trials;cohort;Data;Detection;Development;Effector Cell;env Gene Products;Epitopes;flexibility;Flow Cytometry;Future;gag Gene Products;Gender;Genetic;Genetic Variation;high reward;high risk;HIV;HIV Core Protein p24;HIV-1;Immune;Immunotherapy;improved;In Vitro;Infection;Interruption;Investigation;Knowledge;Lead;Learning;Length;lonely individuals;Measures;Mediating;Methodology;Methods;Modeling;Molecular Conformation;Molecular Virology;monomer;neutralizing antibody;novel;Outcome;Persons;Phagocytosis;prevent;Protein Conformation;protein expression;Proteins;Publishing;reactivation from latency;RNA;RNA Splicing;Role;Surface;Testing;Therapeutic;Therapeutic Uses;Transcript;Translating;Translations;treatment strategy;Viral;Viral Proteins;Virus;virus genetics;Virus Replication

PROJECT_TITLE: Defining HIV Env protein expression in latently infected cells

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative: Phospholipids such as phosphatidylethanolamine are not only fundamental building blocks of cellular and organellar autonomy but additionally have diverse essential biological functions. This proposal focuses on an evolutionarily conserved mitochondrial protein that produces phosphatidylethanolamine, is essential for vertebrate life, and for which there are presently many unresolved questions. As such, results derived from this project will further define the role of mitochondrial phospholipid metabolism in health and disease.

PI_NAMEs: CLAYPOOL, STEVEN MICHAEL (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TITLE: Endoplasmic reticulum-assisted mitochondrial precursor biogenesis and quality control

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Up to one third of the global human population is chronically infected with the protozoan parasite Toxoplasma gondii which can lead to fatal reactivated toxoplasmosis in immune-compromised patients or recurrent ocular disease in otherwise healthy people. The cellular processes mediating Toxoplasma persistence are largely unknown, which precludes strategic development of effective therapies to eliminate chronic-stage parasites. This project will increase our understanding of a cellular pathway that supports parasite homeostasis during chronic infection and uncover the molecular mechanisms underlying long term persistence of the parasites.

PI_NAMEs: THAPRAWAT, PARIYAMON  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acute;Autophagocytosis;Autophagosome;Biogenesis;Biological Assay;Biological Models;Biology;Brain;Cell Physiology;Cells;Chronic;chronic infection;Complement;Complex;Cyst;defined contribution;Development;Disease;Eating;effective therapy;Eukaryotic Cell;Event;Eye;Eye diseases;Goals;Heart;Heart Diseases;Homeostasis;Homologous Gene;Homologous Protein;Human;Imaging Techniques;Immune;Immune System Diseases;Immunoprecipitation;Individual;ineffective therapies;insight;interest;knock-down;Knock-out;Knowledge;Light;Lipids;Measures;Mediating;Membrane;microscopic imaging;Microscopy;model organism;Molecular;Molecular and Cellular Biology;Mus;mutant;Nervous System Disorder;novel;Organelles;Organism;Parasites;Pathogenesis;Pathway interactions;Patients;Persons;Physicians;Play;Population;Process;protein complex;Proteins;Publishing;recruit;Recurrence;Recycling;Reporting;Research;Resolution;Respiratory Disease;Risk;Role;Scientist;Tissues;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;Training;Vertebrates;virtual;Yeasts

PROJECT_TITLE: Defining the role of TgATG9 in Toxoplasma gondii autophagy and persistence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-A(20)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Neurosciences;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed project will have a significant and positive impact on the investigation of multi-level sociocultural, behavioral and biologic pathways contributing to cardiometabolic health and disease risk in Asian American subgroups, address how social determinants of health (SDoH) impact cardiometabolic outcomes, and identify key biologic pathways that mediate these associations. Findings will impact public health practice and policy by pinpointing novel or non-traditional risk factors, identifying the most vulnerable populations and subgroups to target for outreach and intervention, and leading to modifications of clinical screening and prevention guidelines for specific AA populations.

PI_NAMEs: FANG, CAROLYN Y. (contact);HU, FRANK B;MA, GRACE X.

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: Address;Age;American;Asian;Asian Americans;Asian population;Behavioral;Biological;Biological Markers;Biomedical Research;Black Populations;Blood;Cambodian;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Chinese;Chronic Disease;Cities;Clinic;Clinical;clinical examination;cohort;Cohort Studies;Collaborations;Collection;Communities;community advisory board;community organizations;community partnership;Complex;Data;Data Aggregation;Data Collection;Data Reporting;data repository;Diabetes Mellitus;Dietary Assessment;Dietary intake;digital tool;disorder risk;Disparity;Enrollment;Epidemiology;Equity;Ethnic Origin;experience;Filipino;Food;Goals;Growth;Hair;Health;Health behavior;health difference;Health Policy;High Prevalence;high risk;Hispanic Populations;Hypertension;Image;improved;Incidence;Individual;Infrastructure;Intervention;Investigation;Koreans;Language;lifestyle factors;Longitudinal cohort study;Low Prevalence;Mediating;member;men;Methods;Mid-Atlantic Region;Minority;mobile application;Modeling;Modification;Morbidity - disease rate;mortality;multidisciplinary;Nail plate;National Heart, Lung, and Blood Institute;Native Hawaiian or Other Pacific Islander;Nature;Neighborhoods;New Jersey;New York City;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Obesity;Outcome;outreach;Parents;Participant;participant retention;Pathway interactions;Patient Recruitments;Phase;Philadelphia;Pilot Projects;Population;Population Heterogeneity;Prevalence;Prevention Guidelines;Procedures;Productivity;programs;prospective;Protocols documentation;Provider;psychosocial;Public Health Practice;racial population;recruit;Reporting;Research;Research Personnel;Resources;retention rate;Risk;Risk Factors;Sampling;Sampling Studies;screening guidelines;Secure;social culture;social health determinants;socioeconomics;Standardization;standardize measure;Strategic vision;Structure of nail of toe;Subgroup;Urine;Vietnamese;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Asian American Community Cohort and Equity Study (ACCESS)


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BOCA RATON

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

ORG_STATE: FL

PHR: Rural communities experiencing repeated intermittent exposures to air pollution during agricultural burns often face social isolation, and both are linked to increased risk for Alzheimer’s disease and related dementias (ADRD). However, the intersection of these factors, combined with the influence of rural built and social environments on cognitive function have not been studied, particularly in the context of racially/ethnically diverse farmworkers who already face increased ADRD risk. This proposed research will inform the design of public health interventions that can diminish the threat of ADRD in rural settings and save healthcare dollars.

PI_NAMEs: WIESE, LISA ANN (contact);WILLIAMS, CHRISTINE L

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Acceleration;Accounting;Address;Adult;Affect;African American;African American population;aged;Agriculture;Air;Air Pollutants;Air Pollution;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Apple watch;Area;Back;Behavior;Black race;brain health;Buffers;built environment;Burn injury;Canes;Characteristics;Cognitive;cognitive function;Communities;Crime;Data;Data Analyses;Data Collection;Data Sources;Dementia;dementia risk;deprivation;design;Destinations;Diabetes Mellitus;Disadvantaged;Disease;Disparity;Distress;Ecological momentary assessment;economic disparity;Economics;Education;Educational Status;Environment;ethnic diversity;ethnic minority;Ethnic Origin;Ethnic Population;experience;Exposure to;Face;Farm;farm worker;Florida;Goals;Green space;Growth;Health;Health behavior;health determinants;health inequalities;Healthcare;hearing impairment;high risk;Hispanic;Hispanic Americans;Hispanic Populations;Housing;Hypertension;Impaired cognition;improved;Income;Individual;innovation;Interdisciplinary Study;Lead;Linear Models;Linguistics;Link;Longitudinal Studies;Measures;medically underserved;Mental Depression;meter;Methods;middle age;Modeling;modifiable risk;Monitor;Moods;multidisciplinary;neighborhood disadvantage;Neighborhoods;neuroinflammation;Obesity;older adult;Outcome;Participant;Particulate Matter;Persons;Pharmaceutical Preparations;Physical activity;Physical environment;physical inactivity;Population;Population Heterogeneity;prevent;programs;Public Health;public health intervention;public health relevance;Race;racial diversity;racial population;recruit;Reduce health disparities;Research;Research Project Grants;Risk;Risk Factors;Role;Rural;Rural Community;rural dwellers;Rural Population;rural setting;rural underserved;Saccharum;Sampling;Seasons;sensor;Sensory;Series;smart watch;Smoke;Smoking;social;social engagement;Social Environment;social health determinants;Social isolation;Socialization;sociodemographics;symptom treatment;Technology;Testing;Time;Trees;underserved community;urban setting;Walking;Woman;Work

PROJECT_TITLE: The Role of Air Quality and Built Environment in Social Isolation and Cognitive Function among Rural, Racially/Ethnically Diverse Residents at Risk for Alzheimer's Disease

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Aging;Clinical Research;Genetics;Human Genome;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative: This project will clarify changes in genome organization (“epigenome”) that occur due to common severe pneumonia that result in premature aging and increase the risk for mortality. The information gleaned will have practical applications, such as identifying individuals at risk of post-infectious death and premature aging. The information is necessary for treatments that could block or reverse premature immune aging and decreases post-infectious mortality.

PI_NAMEs: DINARDO, ANDREW R (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: age acceleration;age related;Aging;alpha ketoglutarate;Animal Model;Animals;Bacterial Pneumonia;Benchmarking;Bioinformatics;Cardiovascular Diseases;Cell Aging;Cells;Cessation of life;Cicatrix;Citric Acid Cycle;Clinical;clinically relevant;cofactor;COVID-19;Data;DNA;DNA Methylation;Enzymes;epigenetic aging;Epigenetic Process;epigenome;epigenomics;Exclusion;exhaust;experimental study;follow-up;Genome;Glean;Human;Hypermethylation;Immune;immune function;Immunity;improved;In Vitro;in vivo;Individual;Infection;Inflammation;inhibitor;Malignant Neoplasms;Metformin;Modeling;mortality;mortality risk;mouse model;mycobacterial;Outcome;Participant;Pathologic;patient retention;Patients;Pharmaceutical Preparations;Pneumonia;Population;practical application;premature;Premature aging syndrome;preservation;prevent;progenitor;Recovery;recurrent infection;Resolution;Risk;SDZ RAD;Sepsis;Severity of illness;single cell sequencing;stem cells;Succinates;Survivors;T-Lymphocyte;Testing;transcriptome sequencing;Tricarboxylic Acids;United States;Viral Pneumonia;Work

PROJECT_TITLE: Common Post-Infectious Premature Epigenetic Aging

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: Project Narrative The goals of the proposed research are to identify the genetic causes of inherited retinal degenerations (IRDs), define the mechanisms by which mutations in IRD disease genes lead to retinal degeneration, and to use this information to develop effective therapies to prevent vision loss from these blinding disorders. Collectively, IRDs are the most common cause of legal blindness among working-age people, and are estimated to affect more than 5 million people worldwide. Identifying the genetic causes of IRDs and the mechanisms of disease pathogenesis has become especially important as genetic therapies such as gene augmentation therapy and neuroprotective therapies show great promise for the treatment of IRDs, with one approved gene therapy product, and clinical trials of 15 other genetic and neuroprotective therapies in progress.

PI_NAMEs: PIERCE, ERIC A (contact)

PROGRAM_OFFICER_NAME: COOK, TIFFANY

PROJECT_TERMS: Address;Affect;Age;Atrophic;Biological Assay;Blindness;Cells;Cessation of life;Clinical Trials;Cone;Data;design;Development;Disease;DNA Damage;DNA Modification Process;DNA Repair;early onset;effective therapy;Etiology;Exons;Failure;Family;Functional disorder;gene augmentation therapy;Gene Expression;gene therapy;Genes;Genetic;genetic testing;genetic variant;Genome;genome sequencing;Goals;Human body;human induced pluripotent stem cells;human model;inherited retinal degeneration;interest;Introns;Lead;Legal Blindness;legally blind;macula;Mediating;Mendelian disorder;Messenger RNA;Methods;mouse model;Mus;mutant;Mutation;neuroprotection;novel;Nuclear;Organ;Organoids;Other Genetics;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Persons;Phenotype;photoreceptor degeneration;Photoreceptors;Poly(ADP-ribose) Polymerases;precision medicine;preservation;prevent;programs;prospective;Regulatory Element;Research;Research Personnel;response;Retina;Retinal Degeneration;retinal progenitor cell;RNA Splicing;Rod;Role;Source;Testing;Time;Transcript;Translating;Untranslated RNA;Variant;Vision;whole genome

PROJECT_TITLE: Precision Medicine for Inherited Retinal Degenerations

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ORG_NAME: AMERICAN SOCIETY FOR MICROBIOLOGY

PHR: ASM MOSAIC PROJECT NARRATIVE The ASM MOSAIC program is relevant to public health by increasing the diversity of the microbiology and immunology fields, which is important for fostering innovation in basic science research and inspiring individuals from minoritized groups to choose careers in STEM. By helping scientists from minoritized groups realize successful careers at research - intensive universities, the ASM MOSAIC program will contribute toward NIH’s goal of enhancing diversity within the academic biomedical research workforce.

PI_NAMEs: HULEDE, IRENE VERONICA (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Academy;Acculturation;Address;American;Award;Basic Science;Biomedical Research;Books;Businesses;career;Career Choice;career development;career life balance;career networking;Communicable Diseases;Communication;Communities;design;Development;diversity and inclusion;Doctor's Degree;Economics;education research;Educational workshop;Ensure;expectation;Faculty;Fellowship;Fostering;Foundational Skills;Foundations;Funding;Future;Goals;Grant;Grant Review;Growth;Immunologist;Immunology;improved;innovation;Inosine Diphosphate;Institution;Intervention;Interview;Journals;Knowledge;Laboratory Research;Leadership;Learning;Life;Manuscripts;Mediation;meetings;member;Mentors;Mentorship;Microbe;microbial;Microbiology;Minority;Minority Groups;minority scientist;mosaic;next generation;Pathway interactions;Personal Satisfaction;Phase;Policies;Positioning Attribute;Postdoctoral Fellow;Process;Productivity;Professional Organizations;programs;Public Health;Publishing;Reproducibility;Research;Resources;Science;Science, Technology, Engineering and Mathematics;Scientist;Secure;skill acquisition;skills;Societies;Students;symposium;Taxation;teacher;tenure track;Time Management;timeline;tool;Training;training opportunity;Travel;undergraduate student;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Vision;Writing

PROJECT_TITLE: ASM MOSAIC Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Alzheimer’s disease and tauopathies represent significant public health challenges. There is urgent need to expand our knowledge of the underlying mechanisms of these conditions. In this proposal, we aim to dissect the mechanisms underlying the pathogenic effects of aberrant anti-viral immune signaling by cyclic GMP-AMP synthase (cGAS) to advance our understanding of how innate immune system contributes to neurodegeneration and inform the development of more efficacious therapies.

PI_NAMEs: AMIN, SADAF  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Amino Acids;Amyotrophic Lateral Sclerosis;Anti-viral Response;antiviral immunity;Astrocytes;Behavioral Assay;Binding;Brain;brain cell;Cell Culture Techniques;Cell Physiology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;CRISPR screen;Cyclic GMP;Cytoplasm;Cytosol;Data;Dementia;Development;Disease;DNA;DNA Damage;DNA Probes;efficacious treatment;Electrophysiology (science);experimental study;Exposure to;Extracellular Space;Genes;Genetic;Genetic Materials;genome wide association study;Genomic Instability;Gliosis;Hippocampus;Human;human disease;human model;human pluripotent stem cell;hyperphosphorylated tau;Immune;immune activation;Immune response;Immune signaling;Immunohistochemistry;In Vitro;Inflammaging;Inflammatory Response;Innate Immune Response;Innate Immune System;Interferon Activation;Interferons;Knowledge;Learning;Libraries;Mediating;Mediator;Memory impairment;Memory Loss;Microglia;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;Neurons;neurotoxic;neurotoxicity;novel;Nuclear;Nucleic Acids;Parkinson Disease;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Phase;Phenocopy;protective effect;Public Health;response;risk variant;RNA;Role;screening;senescence;Senile Plaques;sensor;Series;Signal Transduction;single nucleus RNA-sequencing;Stimulator of Interferon Genes;Stress;Synapses;Synaptic plasticity;synaptic pruning;System;tau aggregation;tau mutation;tau Proteins;Tauopathies;Time;Toxic effect;transcriptomics;Viral;viral detection;Work

PROJECT_TITLE: Investigating the role of cGAS signaling and microglial senscence in tauopathy

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: Project Narrative Black communities are disproportionally impacted by HIV, in the U.S. in general and in Miami, FL (a southern HIV epicenter) and in our quest to end the HIV epidemic we need to utilize community-driven implementation strategies centering Black individuals and tackling manifestations of structural racism. Our Five Point Initiative (FPI) (a) is a locally developed bundled implementation strategy, (b) harnesses the combined efforts of community experts, businesses, and health organizations, and (c) demonstrates strong evidence of acceptability and feasibility via our 1-year and 2-year Ending the HIV Epidemic (EHE) supplements. Building on an established network with over 80 local businesses, 8 community health organizations, and community HIV experts with unmatched expertise, our proposed study will conduct a stepped wedge cluster randomized trial to test the effectiveness of the FPI implementation strategy in increasing HIV testing, PrEP linkage (e.g., prescription) and knowledge, and condom access/use among Black residents in HIV high impact zip codes.

PI_NAMEs: DALE, SANNISHA K. (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;AIDS prevention;American;barrier to care;base;Beauty;Black Populations;Black race;Businesses;Censuses;Clinical;Clinical effectiveness;Cluster randomized trial;Collaborations;Communities;Community Health;community intervention;Community Surveys;condoms;cost;cultural competence;Data;design;Diagnosis;Discrimination;Dryness;effectiveness evaluation;effectiveness outcome;effectiveness testing;Electronics;Epidemic;Equity;Event;evidence base;Florida;Funding;Future;Gases;Hair;Health;health inequalities;health organization;Health Services Accessibility;Healthcare;HIV;HIV diagnosis;HIV risk;Human immunodeficiency virus test;Hybrids;implementation evaluation;implementation outcomes;implementation strategy;implementation trial;improved;Individual;innovation;Institution;interest;Intervention;Interview;Knowledge;Link;Maintenance;Medical;member;minority communities;Modeling;Neighborhoods;Outcome;outcome disparities;Outcome Study;outreach;Pamphlets;Participant;Periodicals;Policies;Population;post intervention;primary outcome;Prophylactic treatment;Public Health;Public Health Practice;Race;racial disparity;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Restaurants;Risk Factors;Services;social health determinants;Structural Racism;success;Surveys;System;tool;Transportation;Trust;Unsafe Sex;uptake;Variant;volunteer;voucher;Work

PROJECT_TITLE: Five Point Initiative: A Cluster Randomized Trial of a Bundled Implementation Strategy to Address the HIV Epidemic in Black Communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-W(50)R]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative This project combines large-scale, biochemical assays with artificial intelligence techniques to determine the vocabulary of the instructions used by our cells to determine which genes are active under which conditions. Discovering the words (called motifs) of this vocabulary will help scientists to understand which mutations change these instructions and how these changes lead to cancer and other human diseases. As new motifs are uncovered, the sequences of human messenger RNAs will be scanned to try to assign meaning to the motif vocabulary.

PI_NAMEs: HUGHES, TIMOTHY ;MORRIS, QUAID  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: 3' Untranslated Regions;Alternative Splicing;Amino Acid Sequence;anti-cancer research;Artificial Intelligence;Binding;Binding Sites;Biochemical;Biological Assay;Biological Models;Calibration;cancer genetics;Catalogs;Cells;Code;Collaborations;Collection;Computer Models;Computer software;Data;Data Set;deep neural network;Defect;detection method;Development;Evolution;experience;Family;fly;follow-up;Funding;Genes;Genetic Research;genomic data;Genomics;Germ-Line Mutation;Health;Homology Modeling;Human;human disease;Human Genetics;Human Genome;Human Resources;improved;in silico;In Vitro;in vivo;Industry Standard;Instruction;knock-down;Knowledge;Learning;Location;machine learning model;Malignant Neoplasms;Maps;Measures;Messenger RNA;Methods;model organism;Modeling;Mutation;Neurodegenerative Disorders;neurodevelopment;Nuclear Export;open source;Organism;Outcome;Peptides;Play;Polyadenylation;Post-Transcriptional Regulation;posttranscriptional;predictive modeling;preference;Procedures;Process;Protein Binding Domain;protein structure prediction;Proteins;Publications;reconstruction;Regulation;Regulatory Element;Research;Research Support;RNA;RNA Binding;RNA Recognition Motif;RNA Sequences;RNA Splicing;RNA Stability;RNA-Binding Proteins;Role;Scanning;Scientist;Somatic Mutation;Source;Specificity;Speed;Structure;Study models;Techniques;tool;Training;Transcript;transcription regulatory network;transcriptome sequencing;transcriptomics;Translations;user-friendly;Validation;Variant;Vertebrates;Vocabulary;web portal;web-based tool;Yeasts;Zebrafish;Zinc Fingers

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Infectious Diseases;Prevention;Rehabilitation

ORG_DEPT: ORTHOPEDICS

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: NARRATIVE Peri-operative bacterial contamination of joints is thought to be inevitable and aggressive anti-infective procedures are used to minimize adverse outcomes. We will explore how time-dependent changes to the joint fluid critically reduce both the efficacy of antibiotics and the function of host immune cells, and propose to augment bacterial clearance through modulation of joint fluid characteristics and use of ultrasound. The combined therapies are expected to markedly decrease the incidence of peri-prosthetic joint infection.

PI_NAMEs: HICKOK, NOREEN J (contact);SNYDER, CHRISTOPHER M

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Adherence;adverse outcome;aggregation factor;Anti-Infective Agents;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Bacterial Adhesion;Bacterial Antibiotic Resistance;bacterial metabolism;Bathing;Behavior;Cell Physiology;Cells;Characteristics;Clinical;Clinical Treatment;Combined Modality Therapy;Consensus;cytokine;Data;Effectiveness;Environment;Evolution;Family suidae;image guided therapy;Immune;immune activation;immune clearance;immune function;immune phagocytosis;Immune response;Immune system;Immunology;Implant;In Vitro;in vivo;Incidence;Infection;Infection prevention;infection rate;Inflammatory;joint function;joint infection;Joints;Liquid substance;Macrophage;Measures;Metabolic;Metabolism;Microbial Biofilms;Microbubbles;Modeling;Myelogenous;Myeloid Cells;Natural regeneration;novel strategies;novel therapeutic intervention;operation;Operative Surgical Procedures;Orthopedics;pathogen;Perioperative;Periprosthetic joint infection;Phagocytes;Phagocytosis;Phenotype;Postoperative Period;prevent;Prevention;Prevention approach;Procedures;Production;Productivity;Proteins;Proteoglycan;Recurrence;recurrent infection;Replacement Arthroplasty;Serum;Staphylococcus aureus;success;synergism;Synovial Fluid;Testing;Time;Translating;traumatic wound;treatment effect;ultrasound;Virulence Factors;Viscosity;wound

PROJECT_TITLE: The joint environment and periprosthetic joint infection

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Aging;Arthritis;Genetics;Osteoarthritis

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: Project Narrative In recent years, scientific advances have clarified that epigenetic changes to chromatin structure may be responsible for degenerative diseases, and our preliminary findings supports this to be true for the very common and debilitating degenerative disease of the joints, osteoarthritis. Our proposal will dissect the mechanism whereby aging and common cellular stressors result in epigenetic activation of transposable elements in the genome that then trigger osteoarthritis. Upon completion, we will have identified epigenetic mechanisms to target for osteoarthritis prevention and treatment.

PI_NAMEs: WANG, TING ;YANG, TAO  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Adult;Affect;Age;age related;age-related disease;Aging;aging population;aging related;aging related disease;Apoptosis;ATAC-seq;biological age;Biological Models;Cartilage;cell type;Cells;Cellular Stress;ChIP-seq;Chondrocytes;Chromatin;Chromatin Structure;Chronic;Clinical;Data;defense response;Degenerative Disorder;Degenerative polyarthritis;Deposition;Development;Disease Progression;DNA Methylation;DNA Transposable Elements;Double-Stranded RNA;empowerment;Endogenous Retroviruses;Enhancers;Epigenetic Process;epigenome;experimental study;Exposure to;Gene Expression;Genes;Genetic Transcription;Genome;healing;Health;Heterochromatin;Histones;Homeostasis;Human;Impairment;Inflammation;Inflammatory;inflammatory marker;Injury;interest;Joints;Knock-out;Knockout Mice;Mechanics;Mediating;Medical;Methylation;Modeling;Mus;Neurodegenerative Disorders;Nuclear;overexpression;oxidation;Pain management;Pathogenesis;Pattern;Persons;Phenotype;postmitotic;premature;prevent;Prevention;promoter;Recording of previous events;Replacement Arthroplasty;Research;Risk Factors;Role;Sampling;Scientific Advances and Accomplishments;self-renewal;senescence;SETDB1 gene;Societies;Stress;stressor;Surface;Testing;therapy development;Tissues;Transcript;Transcriptional Silencer Elements;transcriptome;transcriptome sequencing;transcriptomics;translational potential;Viral;Wild Type Mouse;Work

PROJECT_TITLE: Endogenous retrovirus in joint aging and osteoarthritis development


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE The primate retina contains an incredible diversity of retinal circuits, the majority of which have not been characterized or integrated into models of primate vision. This project will use retinal physiology, circuit tracing and measures of behavior, all in the living macaque eye, to elucidate the roles of the rare retinal output neurons in primate vision, both in health and disease. The results will clarify the timeline of retinal degeneration following V1 stroke damage and the division of labor between the retina and the brain to inform techniques that seek to restore appropriate signals in the retinas of the blind.

PI_NAMEs: PATTERSON, SARA S (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Ablation;Action Potentials;Acute;adaptive optics;Advisory Committees;Amacrine Cells;Area;Behavior;Behavioral;blind;Blindness;Brain;Calcium;career;Cell Communication;Cell Physiology;cell type;Classification;Code;Conscious;Cortical Blindness;Detection;Disease;Electrophysiology (science);experimental study;Eye;Eye Movements;Faculty;Feedback;Fluorescence;Foundations;ganglion cell;Goals;Health;Image;Imaging Techniques;improved;in vivo;in vivo calcium imaging;Individual;Investigation;Knowledge;Lasers;Lesion;Light;Link;Longitudinal Studies;Macaca;Measures;Mediating;Mentors;Modeling;Motion;neural;Neurons;Ophthalmoscopy;optical imaging;Optokinetic nystagmus;Output;Pathway interactions;Patients;Phase;Physiological;Physiology;Population;Positioning Attribute;preservation;Primates;Property;Reflex action;Research;Resolution;response;Retina;Retinal Degeneration;Retinal Ganglion Cells;Retrograde Degeneration;Role;Scanning;Signal Transduction;skills;Source;Speed;Standard Model;Stroke;Structure;Technical Expertise;Techniques;temporal measurement;tenure track;Testing;timeline;tool;Tracer;Training;Trans-Synaptic Degeneration;transmission process;Universities;Viral Vector;Vision;Visual;Visual Cortex;Visual impairment;visual information;visual neuroscience;Visual Pathways;Visual Perception;visual processing;Visual System;Visualization;voltage

PROJECT_TITLE: Linking rare primate ganglion cells to downstream visual functions


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;HIV/AIDS;Infectious Diseases;Lung;Pulmonary Hypertension

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Chronic HIV infection leads to significant respiratory morbidity as well as irreversible changes on lung function testing; of those, isolated abnormality in the diffusing capacity for carbon monoxide in the context of normal spirometry, iso↓DLco, is the most common abnormality. Iso↓DLco as a lung function phenotype in HIV is incompletely understood though it is associated with increased respiratory symptom burden and a unique pattern of inflammation and immune activation. The purpose of this study is to characterize the epidemiology, etiology, and the possible contributors to the pathogenesis of iso↓DLco, so that specific therapies can be designed to reduce respiratory symptoms and improve the quality of life for people living with HIV.

PI_NAMEs: BYANOVA, KATERINA L. (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Acute;Affect;Africa South of the Sahara;Air;Biological Markers;Blood Vessels;Bronchodilator Agents;California;Carbon Monoxide;carotid intima-media thickness;Chest;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Investigator;Clinical Research;clinically relevant;co-infection;cohort;Cohort Studies;comorbidity;Critical Care;Cytomegalovirus;Cytomegalovirus Infections;Data;design;Diagnosis;Diffusion;Disease;Distal;DNA;Endothelium;Epidemiology;Etiology;Foundations;Functional disorder;General Population;Goals;Grant;HIV;HIV Infections;HIV Seronegativity;Image;immune activation;Immunoglobulin G;Immunoglobulin M;Immunologic Markers;immunosuppressed;improved;Individual;Infection;Inflammation;Inflammatory;interstitial;Interstitial Lung Diseases;Intervention;K-Series Research Career Programs;Knowledge acquisition;Link;Literature;Longitudinal cohort;Lung;Lung Diseases;Measurement;Measures;Mediating;Methods;modifiable risk;novel strategies;Obstruction;Participant;Pathogenesis;patient oriented;Pattern;Persons;Phenotype;Pilot Projects;Plasma;Population;Prevalence;prevent;Proliferating;Pulmonary Emphysema;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;Pulmonary Hypertension;pulmonary vascular remodeling;Pulmonary vessels;Quality of life;Questionnaires;Research;Research Infrastructure;respiratory morbidity;Respiratory Signs and Symptoms;Risk Factors;San Francisco;Serum;skills;Spirometry;Symptom Burden;Symptoms;targeted treatment;Techniques;Testing;Therapeutic Intervention;Thrombosis;Training;Uganda;Universities;Vascular Diseases;Virus;Work

PROJECT_TITLE: Isolated Abnormality in the Diffusion Capacity for Carbon Monoxide in People Living with HIV – Epidemiology, Etiology and Pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F17A-H(20)]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative Mitochondrial biogenesis involves nuclear and mitochondrial gene expressions. Here, I propose to study how the two gene expressions are spatially coordinated. The results will enhance our understanding in the basic biology of mitochondria, and provide insights into mitochondrial diseases.

PI_NAMEs: LI, WEIHAN  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Adult;Alzheimer's Disease;Binding Proteins;Biochemistry;Biogenesis;Biology;Brain;Cardiac Myocytes;Cells;Cellular biology;Communication;Cytosol;Disease;Doctor of Philosophy;Endoplasmic Reticulum;experimental study;Face;Fluorescent in Situ Hybridization;Foundations;Future;Gene Expression;Genetic;Genome;Health;Heart failure;Human;Image;Immobilization;In Situ;In Situ Hybridization;insight;Knowledge;Knowledge acquisition;Laboratories;live cell imaging;Membrane;Mentors;Messenger RNA;Mitochondria;Mitochondrial Diseases;mitochondrial genome;Mitochondrial Matrix;mitochondrial messenger RNA;Mitochondrial Proton-Translocating ATPases;Molecular;molecular imaging;mRNA Translation;Mutation;Nature;Neurons;novel;Nuclear;Organelles;Oxidative Phosphorylation;Phase;post-doctoral training;Production;programs;Proteins;Regulation;Research;RNA-Binding Proteins;Schizophrenia;Series;Side;single molecule;Site;skills;stoichiometry;Synapses;Technology;Testing;Training;Translating;Translation Initiation;Translational Repression;Translations;Weight;Yeasts

PROJECT_TITLE: Spatial coordination of cytosolic and mitochondrial translation


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Relevance to Public Health Defects during oocyte maturation result in aneuploidy (abnormal number of chromosomes) and reduced egg quality, major causes of infertility and developmental disorders. Using human, bovine and porcine oocytes, this project will disentangle fundamental molecular mechanisms underpinning egg quality. This knowledge will lead science closer to developing new approaches aimed at improving oocyte quality, thereby improving female fertility and offspring wellbeing.

PI_NAMEs: BALBOULA, AHMED  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Ablation;Aneuploidy;Animals;Area;Assisted Reproductive Technology;Behavior;Cattle;Cell division;Cell Nucleus;chromosome number abnormality;Chromosomes;Clinical;comparative;Competence;Congenital Abnormality;Defect;Development;developmental disease;early pregnancy loss;egg;Embryo;Ensure;Event;Family suidae;Female;female fertility;Fertility;Generations;Genetic;Germ Cells;Goals;Human;improved;Infertility;innovation;Insurance;Knowledge;Lasers;Lead;Meiosis;Microtubules;Molecular;Molecular Analysis;multi-photon;multiple omics;Mus;National Institute of Child Health and Human Development;novel strategies;offspring;oocyte maturation;oocyte quality;Oocytes;Peripheral;Personal Satisfaction;Positioning Attribute;Pregnancy;premature;Process;Public Health;Reproductive Health;Research;Risk Factors;Science;Signal Transduction;success;superresolution microscopy;Work

PROJECT_TITLE: Comparative analysis of molecular events in mammalian oocytes


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Organ Transplantation;Transplantation

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative In the United States, more than 24 million people suffer from autoimmune disease and over 600,000 people die of cancer each year. These maladies are predominantly a consequence of inappropriate orchestration of immunological tolerance, yet few therapies exist to precisely control the associated processes. In this project, we develop an entirely new class of living cell therapies that home to sites of tolerance induction and reprogram immune responses to fight cancer and quell autoimmunity.

PI_NAMEs: RETICKER-FLYNN, NATHAN EDWARD (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Adjuvant;Adverse event;Anatomy;anti-tumor immune response;Antigen Presentation;Antigen-Presenting Cells;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactivity;Benign;cancer immunotherapy;Cell Therapy;Cells;Cellular biology;central tolerance;chimeric antigen receptor;Chronic;Clinical;Clonal Anergy;Clonal Deletion;Communicable Diseases;cytokine;Cytolysis;Dendritic Cells;Disease;Disseminated Malignant Neoplasm;Education;Endowment;engineered T cells;Engineering;Equilibrium;fetal;fighting;Generations;Genome engineering;Goals;Graft Tolerance;Heart;Home;Homeostasis;Homing;Immune;immune activation;Immune checkpoint inhibitor;Immune response;Immune System Diseases;Immune Tolerance;immune-related adverse events;Immunocompromised Host;Immunologic Adjuvants;Immunologic Memory;Immunosuppression;Immunosuppressive Agents;Immunotherapy;Ligation;lymph nodes;Lymphocyte;Maintenance;Malignant Neoplasms;Molecular;Neoplasm Metastasis;novel;Oncology;Organ Transplantation;pathogen;Pathogenicity;Pathology;Patients;Peripheral;peripheral tolerance;Persons;Pharmaceutical Preparations;post-doctoral training;Pregnancy;prevent;Prevention;Process;Production;programs;Reactive Inhibition;Regulatory T-Lymphocyte;Research;Resistance;Resolution;response;reverse tolerance;secondary lymphoid organ;Site;Solid;Steroids;synthetic biology;T cell therapy;T-Lymphocyte;Therapeutic;therapy development;Thymus Gland;Tissues;tool;trafficking;Transplantation;Transplantation Tolerance;Tuberculosis;tumor;Tumor Immunity;United States

PROJECT_TITLE: A modular cell therapy platform for controlling immunological tolerance


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Therapeutics and Interventions;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Lung;Rare Diseases

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Acute respiratory distress syndrome (ARDS) is a common form of respiratory failure in patients receiving mechanical ventilation, and carriers a high risk of death. Despite historically low adoption of prone positioning, a key evidence-based therapy for ARDS, there was a rapid and widespread uptake of its use in ICU practice for ARDS during the coronavirus disease 19 pandemic. In this research, we investigate the strategies needed to sustain this widespread use of proning in ICU practice.

PI_NAMEs: HOCHBERG, CHAD  (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Adoption;Agreement;Award;Belief;career;career development;Chad;Characteristics;Climate;Computerized Medical Record;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19/ARDS;Critical Care;Data;Data Analyses;Data Set;design;Development Plans;Disease;efficacy outcomes;Eligibility Determination;Environment;Etiology;evidence base;Evidence based practice;experience;Face;falls;Feedback;Foundations;Funding;Future;Gases;Goals;Guidelines;hands on research;Health system;high risk;hospital care;Hospitals;implementation evaluation;implementation framework;implementation intervention;Implementation readiness;implementation science;implementation strategy;implementation trial;improved;Informatics;Intensive Care Units;Interdisciplinary Study;Intervention;Interview;Investigation;K-Series Research Career Programs;Leadership;Learning;Life;Lung;Measures;Mechanical ventilation;member;Mentors;Mentorship;Meta-Analysis;Methods;Monitor;Morbidity - disease rate;mortality;mortality risk;novel;Organization administrative structures;organizational climate;Organizational Culture;organizational readiness;pandemic disease;Patient Care;Patient-Focused Outcomes;Patients;Penetration;Positioning Attribute;primary outcome;Process;Prone Position;Recommendation;Research;Research Personnel;Respiratory Failure;Retrospective cohort study;Review Literature;Risk Reduction;routine practice;Severities;Site;Stomach;Structure;Survey Methodology;Surveys;sustainability framework;Syndrome;Testing;Time;Training;Universities;uptake;Work

PROJECT_TITLE: Sustainable Implementation of Prone Positioning for the Acute Respiratory Distress Syndrome

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The extracellular matrix (ECM) is a complex protein meshwork that constitutes the architectural scaffold of all tissues and organs. Alterations in the ECM have been linked to a plethora of diseases, including fibrosis and cancer. Our work proposes to understand the fundamental mechanisms leading to the assembly of the ECM meshwork. Doing so is the first step toward understanding how ECM alterations lead to diseases and toward the development of therapeutic strategies to prevent or revert disease-causing ECM alterations.

PI_NAMEs: NABA, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Address;adhesion receptor;Adhesions;Adhesives;aggressive breast cancer;Antibodies;Architecture;Binding;Binding Sites;Biochemical;Biological Assay;Breast Cancer Patient;Cardiovascular Diseases;Cell Adhesion;cell behavior;Cell Line;cell motility;Cell Physiology;Cell Proliferation;Cell surface;Cells;clinically relevant;Collagen;Complex;Confocal Microscopy;Connective Tissue Diseases;Coupled;Craniofacial Abnormalities;craniofacial development;Data;Defect;deoxycholate;Development;Developmental Process;dimer;Disease;Disease Progression;EGF gene;EGF-Like Domain;Electron Microscopy;Embryonic Development;Essential Genes;Extracellular Matrix;Extracellular Matrix Proteins;Fiber;fibrillin;Fibroblasts;Fibronectins;Fibrosis;Future;Genetic;Goals;Homeostasis;Immunofluorescence Immunologic;In Vitro;insight;Integrin Binding;Integrins;interest;Interferometry;Knock-out;Knockout Mice;Knowledge;Label;Laboratories;Lead;Link;Malignant Neoplasms;Mammary Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Metabolic;Microscopy;migration;molecular modeling;mouse model;Musculoskeletal Diseases;Mutation;Neonatal;Neoplasm Metastasis;neoplastic cell;Neural Crest Cell;Nidogen;novel;Organ;Patients;pharmacologic;Phenotype;prevent;Prognosis;promoter;Property;Protein Biochemistry;protein complex;protein purification;Proteins;Proteomics;receptor;Role;scaffold;Sequence Analysis;Signal Transduction;Structure;Sushi Domain;System;Tertiary Protein Structure;Testing;Therapeutic;therapeutic development;Time;Tissues;tool;tumor progression;Variant;Work

PROJECT_TITLE: Mechanisms guiding the fibrillar assembly of SNED1 in the extracellular matrix


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Novel diazabicyclooctane-containing b-lactam/b-lactamase inhibitor combinations, a new class of broad- spectrum antibacterial agents in late clinical development, have activity against highly multidrug-resistant gram- negative bacteria that few other antibiotics can treat. However, bacteria may develop resistance to these new drugs during treatment, leaving patients with few, if any, options for treatment of highly resistant pathogens. The proposed research project aims to investigate mechanisms by which bacteria become resistant to these novel combinations and to determine which combinations are most resilient against the emergence of resistance, thereby protecting these agents for ongoing clinical use.

PI_NAMEs: BRENNAN-KROHN, THEA  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Affinity;Anti-Bacterial Agents;Antibiotics;antimicrobial;Bacteria;bacterial resistance;Base Pairing;beta-Lactamase;beta-Lactams;Binding;Biological Assay;carbapenemase;Ceftazidime;Clinical;clinical development;Clinical Research;Clinical Trials;Collection;Complex;Data;Development;Drug Exposure;Drug resistance;Enhancers;Enterobacter cloacae;Escherichia coli;Exhibits;Exposure to;Extended-spectrum β-lactamase;Fiber;Frequencies;Future;Gene Expression Profiling;genome sequencing;Genomics;Goals;Gram-Negative Bacteria;Growth;in vitro Assay;in vivo;Infection;inhibitor;inhibitor therapy;Klebsiella pneumoniae;Knowledge;Lactamase;Lactams;Mediating;Methods;Methylation;Modeling;Monobactams;Multi-Drug Resistance;Multiple Bacterial Drug Resistance;Mus;Mutation;novel;novel therapeutics;Organism;pathogen;Patients;Penicillin Binding Protein 2;Pharmaceutical Preparations;preclinical study;Predisposition;preservation;prevent;priority pathogen;Pseudomonas aeruginosa;Regimen;Research Project Grants;resilience;Resistance;Resistance development;resistance frequency;resistance mechanism;response;Risk;Role;Safety;Serine;simulation;suicide substrates;Testing;Thigh structure;Time;transcriptome sequencing;transcriptomics;whole genome;Work

PROJECT_TITLE: Susceptibility and resistance of multidrug-resistant gram-negative bacteria to novel beta-lactam/beta-lactamase inhibitor combinations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Urologic Diseases

ORG_CITY: SHREVEPORT

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: PROJECT NARRATIVE The link between non-alcoholic fatty liver disease (NAFLD), affecting one third of the world population, and aggravated atherosclerotic cardiovascular disease, the major cause of death in patients with NAFLD, is poorly understood, hindering the development of effective therapies for simultaneous targeting. We uncovered that oxalate overproduction in the fatty liver concurrently fuels further progress of NAFLD and aggravation of atherosclerosis. We will address the molecular and metabolic mechanisms behind oxalate acting as a link between both diseases and provide evidence for the effectiveness of targeted therapies aimed at reducing oxalate, with the ultimate objective of accelerating translation of our findings into concurrent treatment of these two prominent diseases.

PI_NAMEs: ROM, OREN SHALOM (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Acceleration;Accounting;Affect;Alanine-glyoxylate aminotransferase;Atherosclerosis;Attenuated;Cardiometabolic Disease;Cardiovascular Diseases;Cause of Death;Cells;chemokine;chronic liver disease;Clinical;Development;dietary;dietary approach;Disease;drug development;Drug Metabolic Detoxication;effective therapy;Effectiveness;efficacy evaluation;Enzymes;Epigenetic Process;Fatty Acids;Fatty Liver;Functional disorder;Genes;Genetic;genetic approach;Genetic Variation;genome wide association study;genome-wide;glyoxylate;Hepatic;Hepatocyte;hepatocyte injury;Human;Impairment;improved;In Vitro;in vitro Model;in vivo;Inflammation;Inflammatory;Kidney;Ligands;Link;Lipids;Liver;Liver Fibrosis;Liver Mitochondria;Lobular;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Modification;Molecular;mortality;mouse model;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;overexpression;Oxalates;oxidation;Pathway interactions;Patients;pharmacologic;Pharmacotherapy;Population;PPAR alpha;prevent;Production;RANTES;Reducing Agents;Regulation;Risk;Risk Factors;Role;Sampling;Severities;Severity of illness;targeted treatment;Testing;Therapeutic;transcriptomics;Translations;Vitamin B6;Work

PROJECT_TITLE: Dysregulated Oxalate Metabolism in Cardiometabolic Diseases

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Neurosciences;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE The PONO study will establish a new prospective, multi-generational cohort on cardiopulmonary and metabolic health among the understudied sub-populations of Native Hawaiians (NH) and Micronesian Pacific Islanders (PI). The long term goal of the study is to use novel “populomics” research approaches to unravel the complexities of health inequities and contribute to the larger cohort of 10,000 Asian Americans-NH-PI aimed at filling a gap in understanding of CPM health disparities between and within these heterogenous populations compared with the general US population.

PI_NAMEs: MAU, MARJORIE K. LEIMOMI MALA (contact);MAUNAKEA, ALIKA KEOLAOKALANI;PARK, SUNGSHIM LANI

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: Address;Age;age group;Age of Onset;Age Years;Asian Americans;Behavior;Behavioral;biobank;Biological;Biological Factors;Blood;blood-based biomarker;Body mass index;Cardiopulmonary;Cardiovascular Diseases;Cause of Death;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinic Visits;Clinical;Clinical Research;cohort;Cohort Studies;Collaborations;Communities;community engagement;community organizations;Complex;Data;Data Reporting;data standards;Diabetes Mellitus;diabetes risk;Diet;Disease;Disease Outcome;Disparity;early onset;Electronic Health Record;Enrollment;Environmental Exposure;Enzyme-Linked Immunosorbent Assay;Epidemiology;epigenomics;ethnic diversity;Ethnic Origin;Family;Feces;Federally Qualified Health Center;follow-up;Future Generations;gene environment interaction;Generations;Genetic;Glycosylated hemoglobin A;Goals;Hawaii;Health;Health behavior;Health Disparities Research;health disparity;health inequalities;Heterogeneity;Home;Household;immune function;Immunologics;Incidence;Individual;Inflammation;innovation;Institutional Racism;Intervention Studies;Investments;Knowledge;life span;Life Style;Longitudinal Studies;Measures;Mediating;Medical;Metabolic;Metabolic Diseases;Methodology;microbiome;mortality;multi-racial;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Observational Study;Outcome;Outcome Measure;Pacific Islander;Pacific Ocean;Participant;Periodicals;Persons;Phase;Physical activity;Population;population based;Prevalence;Process;prospective;Protocols documentation;psychosocial;Pulmonary Heart Disease;Questionnaires;Race;racial population;Recording of previous events;recruit;Research;Research Design;Research Personnel;resilience factor;Resources;Risk;Risk Factors;sample collection;Sample Size;Severities;sex;Smoking;social;social health determinants;Social Network;socioenvironmental factor;Technology;Testing;Time;Tissues;Trauma;Universities;Urine;Variant;Visceral;Visit;Work

PROJECT_TITLE: The Pacific Ocean Native Observational (PONO) Health Legacy Study


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prevention

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The analyses of cancer genomes have provided remarkable insights into the origin of cancer and exposed features that have been leveraged for prevention and treatment. This proposal will provide support for a scientist skilled in laboratory and computational genomics to engage a range of translational researchers developing approaches to improve cancer outcomes.

PI_NAMEs: COLEMAN, ILSA  (contact)

PROGRAM_OFFICER_NAME: SCROGGINS, BRADLEY TODD

PROJECT_TERMS: Basic Science;Bioinformatics;Biometry;cancer genome;cancer genomics;clinical care;Clinical Data;Clinical Medicine;Communities;Complex;computerized tools;Data;design;Development;Dimensions;Disease;Environmental Exposure;epigenomics;Genetic;genome-wide;genomic data;Genomics;Heritability;Human;Immunologics;improved;in vivo;insight;Laboratories;Malignant Neoplasms;Modeling;novel strategies;Outcome;precision medicine;Prevention;Productivity;programs;Reproducibility;Research;Research Personnel;response;Scientist;skills;Specialist;Testing;Therapeutic;translational scientist;tumor

PROJECT_TITLE: Research Specialist in Cancer Genomics to Integrate Basic Research and Clinical Data


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

PHR: Project Narrative This population-based prospective cohort study aims to characterize cardiometabolic profiles and psychosocial and other factors in 2,100 Chinese, Filipino, and Vietnamese Americans residing in three counties in the San Francisco Bay Area through comprehensive in-depth surveys, clinical assessments and assays, imaging studies, digital technology, and multi-omics to gain a better understanding of disease risk factors and health outcomes in these understudied but rapidly expanding populations. 1

PI_NAMEs: HSING, ANN  (contact);KUSHIDA, CLETE A;PALANIAPPAN, LATHA P;WU, JOSEPH C.

PROJECT_TERMS: Address;Affect;Age;American;Anxiety;Area;Asian;Asian Americans;Asian population;Biological Assay;Biology;Biosensing Techniques;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Caucasians;Chinese;Chronic Disease;Clinical;Clinical assessments;Clinical Markers;cohort;Cohort Studies;Collaborations;Collection;Communities;County;Data;Data Collection;Development;Diabetes Mellitus;Diagnosis;digital technology;Dimensions;Discrimination;Disease;disorder prevention;disorder risk;Dyslipidemias;Educational workshop;Electronic Mail;Enrollment;epidemiologic data;Epidemiology;Ethnic Origin;Ethnic Population;experience;Filipino;follow-up;Future;Genetic Variation;Guidelines;Health;Health Sciences;Heart Rate;heart rate variability;Hypertension;imaging study;Immigrant;Immigration;improved;Information Dissemination;innovation;Knowledge;Life;Linguistics;low health literacy;Low income;marginalization;Measures;member;men;Mental disorders;Mental Health;Metabolic syndrome;Mood Disorders;multi-ethnic;multidisciplinary;multiple omics;National Heart, Lung, and Blood Institute;Native Hawaiian or Other Pacific Islander;Neighborhoods;Newsletter;non-alcoholic fatty liver disease;Obesity;Obstructive Sleep Apnea;Outcome;Outcome Assessment;Participant;participant retention;patient engagement;Patient Self-Report;Pattern;perceived stress;Personal Satisfaction;Persons;Phenotype;Photoplethysmography;Physical activity;physical conditioning;poor health outcome;Population;population based;population health;Prediabetes syndrome;Prevalence;Prevention Research;Prevention strategy;Procedures;Prospective cohort;Prospective, cohort study;Protocols documentation;Psychology;psychosocial;Psychosocial Factor;Psychosocial Influences;Recording of previous events;recruit;Refugees;Reporting;Research;Research Personnel;Resources;Risk Assessment;Risk Factors;Sampling;San Francisco;screening program;sensor;Site;Sleep;Sleep Architecture;Sleep Disorders;sleep quality;social media;social stress;socioeconomic disadvantage;socioeconomics;statistics;Stress;Stroke;Subgroup;Surveys;Technology;Technology Assessment;temporal measurement;Time;Trauma;United States;United States National Institutes of Health;Variant;Vietnamese;Viral hepatitis;wearable device;Woman

PROJECT_TITLE: Asian American Prevention Research: A Populomics Epidemiology Cohort (ARISE)


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: CHEMISTRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The proposed research focuses on understanding the pathological and physiological consequen- ces of our discoveries that lipid oxidation in the retina leads to the production of glutathione derivatives that promote inflammation by masquerading as proinflammatory molecules including leukotrienes. These discoveries represent a mechanistic link between free radical-induced lipid oxidation and inflammation in the retina that contributes to age-related macular degeneration. We will determine signaling pathways that these molecules activate addressing the questions: how do they promote inflammation in ocular pathology, and do they promote self-cleaning (autophagy) of damaged retina cells?

PI_NAMEs: SALOMON, ROBERT GERD (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Abbreviations;Acids;Address;Age related macular degeneration;Agonist;Anabolism;analog;arachidonate;Autophagocytosis;Biological;Cells;Choroid;clinical development;Complex;cross reactivity;cysteinyl leukotriene receptor;cysteinyl-leukotriene;Cytokine Signaling;Detection;Development;disabling disease;Disease;Disease Marker;Docosahexaenoic Acids;Esters;Ethanolamines;Exhibits;Eye diseases;Free Radicals;Functional disorder;Gene Expression;Generations;Glutathione;Human;Immunoassay;In Vitro;in vivo;Inflammation;Inflammatory;insight;Interleukin-13;Knowledge;Lactones;Lecithin;Leukotriene A4;Leukotriene C4;Leukotriene D4;Leukotriene E4;Leukotriene Receptor;Leukotrienes;Light;Link;Lipids;Measures;Metabolism;Mitochondria;Modeling;Molecular;NADH;novel therapeutics;Ocular Pathology;oxidation;Oxidative Stress;Oxygen;Pathogenesis;Pathologic;Pathologic Neovascularization;Pathology;Phospholipase A2;Phospholipids;Physiological;Physiology;Pilot Projects;polyunsaturated fat;Post-Translational Protein Processing;Production;protein expression;Pyrroles;Rattus;receptor;Research;response;Retina;retinal damage;Retinal Degeneration;Retinal Edemas;Role;Scheme;Signal Pathway;Structure;Structure of retinal pigment epithelium;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Time;transcriptome sequencing;Zileuton

PROJECT_TITLE: Glutathionylated Products of Radical-Induced Lipid Oxidation in Inflammatory Disease

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Aging;Clinical Research;HIV/AIDS;Health Services;Prevention;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Multimorbidity in aging populations is a major public health threat, and the impact is magnified in persons with HIV, who experience a higher burden and decade-earlier onset of aging-related comorbidities. Despite this, HIV primary care guidance does not specifically address managing multimorbidity and therefore, this proposal leverages a well-established HIV cohort to assess multimorbidity cascades, clusters, and progression markers to guide the development of clinical tools for multimorbidity screening and prevention. Completion of the proposed training and research will foster the development of an HIV translational clinician-scientist and will build evidence to inform strategies to promote healthy aging in HIV.

PI_NAMEs: COLLINS, LAUREN FRANCES (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Affect;Age;age related;aged;Aging;aging biomarker;aging process;aging related;Albuminuria;Alzheimer's Disease;Angiography;Award;Biological Markers;Biometry;Blood Pressure;Blood Vessels;Bone Diseases;Cardiovascular Diseases;care delivery;care outcomes;career;career development;CD8B1 gene;Chronic;Chronic Disease;Clinic;Clinical;clinical development;Clinical Practice Guideline;Cognitive;cohort;Cohort Studies;collaborative environment;comorbidity;cost;Cross-Sectional Studies;Data;density;design;Development;Development Plans;Diabetes Mellitus;Disease;Disproportionately impacts women;Early Intervention;early onset;Elements;Enrollment;Epidemiologist;Epidemiology;Evolution;experience;follow-up;Fostering;Funding;Gender;General Population;Geroscience;Glycosylated hemoglobin A;Goals;Health;health care service utilization;Healthcare;healthy aging;high risk;HIV;HIV Seronegativity;Individual;Inflammation;Inflammatory;innovation;Intervention;Life;Life Expectancy;life span;Longitudinal Studies;longitudinal, prospective study;Low-Density Lipoproteins;Measures;Mediating;Mediator;men;Mentors;Methods;Modeling;Modernization;Modification;multiple chronic conditions;non-invasive imaging;novel;Optical Coherence Tomography;Organ;Participant;patient oriented;Patient Recruitments;Pattern;peer;Persons;Population;Postmenopausal Osteoporosis;pre-clinical;premature;Premature Mortality;Prevention;Primary Care;progression marker;Public Health;public health intervention;Quality of life;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Retina;retinal imaging;Risk;Risk Assessment;Risk Factors;risk sharing;Science;Scientist;screening;Sentinel;sex;sociodemographics;Survival Analysis;Techniques;Testing;Time;tool;Training;Translating;translational physician;translational scientist;trend;Universities;Vascular Diseases;Viremia;Woman;Women's Health;Work

PROJECT_TITLE: An EYE toward healthy aging in HIV: building evidence for multimorbidity screening and prevention

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Prevention;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Lymphocytes and many types of primary cells undergo differentiation and progressively lose their stem cell-like properties. While differentiation is important to reduce the risk of oncogenic transformation, it hampers the generation of memory lymphocytes or hematopoietic progenitors. We will dissect the mechanisms by which proliferation is coupled to differentiation and seek to selectively inhibit differentiation of mature lymphocytes, which may facilitate efficacious immunotherapies against infection and cancers.

PI_NAMEs: EGAWA, TAKESHI  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Activated Lymphocyte;Address;Adoptive Cell Transfers;Affinity;Antibodies;Antigen Receptors;Antigens;B cell differentiation;B-Lymphocytes;Binding;c-myc Genes;cancer therapy;CD8-Positive T-Lymphocytes;cell injury;Cell Proliferation;cell type;Cells;chimeric antigen receptor T cells;Chronic;Clonal Expansion;Coupled;cytotoxic;Data;Development;Dissection;Dissociation;Effector Cell;efficacious treatment;exhaustion;experimental study;factor C;gene regulatory network;Generations;Genes;Genetic;Goals;Hematopoietic stem cells;Human;Immunity;Immunotherapy;in vivo;Infection;Infection Control;insight;Interferon Type II;Invaded;Link;Longevity;Lymphocyte;lymphocyte proliferation;Lymphoma;Lymphomagenesis;Malignant Neoplasms;Mature Lymphocyte;Mechanics;Mediating;Memory;Memory B-Lymphocyte;Memory Loss;Molecular;Mus;Mutation;Oncogenic;pathogen;Plasma Cells;Plasmablast;postnatal;prevent;Process;progenitor;programs;Proliferating;Property;response;Risk Reduction;self-renewal;stem;stem cell differentiation;stemness;Structure of germinal center of lymph node;T cell response;T-Lymphocyte;Testing;transcription factor;Transcription Initiation;Transcriptional Silencer Elements;Translating;tumor;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Virus Diseases

PROJECT_TITLE: The transcription factor c-MYC in lymphocyte expansion and restriction of stemness


NIH_SPENDING_CATS: Cachexia;Cancer;Digestive Diseases;Lung;Lung Cancer;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE  Cancer cachexia is a syndrome characterized by weight loss secondary to skeletal muscle and adipose tissue wasting that occurs in certain cancer types, such as lung, pancreatic and gastrointestinal, and advanced stages of other cancer types. Despite the prevalence and grave consequences of this syndrome, the mechanisms underlying cancer cachexia remain unknown and there are currently no available treatments. The proposed studies are designed to address the critical barrier of translating the data from animal models into human cancer patients by developing and testing novel murine models of cancer cachexia and in vitro models to further define the pathoetiology of cancer cachexia, identify therapeutic targets, and provide an experimental platform for testing pharmacotherapeutic and supportive care interventions.

PI_NAMEs: TOTH, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;adverse outcome;Affect;animal data;Animal Model;Animals;Basic Science;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Etiology;Cancer Model;Cancer Patient;cancer type;Cell Culture Techniques;Cells;Cessation of life;Clinical;clinically relevant;Complex;Data;design;Development;Diagnosis;Drug resistance;effective therapy;Enzymes;Event;Exhibits;experience;fat wasting;Functional disorder;gastrointestinal;Genetically Engineered Mouse;Goals;Growth;Human;Immunotherapy;In Vitro;in vitro Model;in vivo;inhibitor;Intervention;K-ras mouse model;Knowledge;KRAS oncogenesis;Lipase;Lipolysis;Low Prevalence;Lung;Lung Adenocarcinoma;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;Metabolic Pathway;Metabolism;Modeling;mortality;mouse model;Mus;Muscle;Muscle Cells;Muscle Fibers;Mutate;Mutation;Neoplasm Metastasis;novel;novel therapeutic intervention;Organ;Organoids;Pancreas;Pathway interactions;Patients;Peripheral;pharmacologic;Phenotype;Pre-Clinical Model;Prevalence;Prevention;programs;release factor;response;Risk;Role;Secondary to;side effect;Skeletal Muscle;skeletal muscle wasting;Supportive care;Syndrome;System;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Time;Tissues;tool;Toxic effect;transcriptomics;Translating;Translations;Treatment-Related Cancer;Treatment-related toxicity;tumor;Tumor Burden;tumor growth;Tumor-Derived;wasting

PROJECT_TITLE: Development of a clinically relevant mouse model of lung cancer cachexia to study pathoetiology and therapeutic strategies


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Social Determinants of Health;Vaccine Related

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Residents of correctional facilities are disproportionately at risk of developing and dying of COVID-19. To mitigate the spread of SARS-CoV-2, Departments of Correction have instituted prevention measures including vaccine campaigns, social distancing, and mass screening. Through this proposal, we seek to derive an evidence base for these prevention measures and develop an adaptive intervention simulation model to identify scenarios when prevention measure modification is justified.

PI_NAMEs: LIND, MARGARET  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Active Learning;adaptive intervention;Advisory Committees;Affect;Award;burden of illness;Calibration;career;combat;Communicable Diseases;Communities;community burden;community-level factor;Complex;Connecticut;Contracts;Coupled;COVID-19;COVID-19 burden;COVID-19 mortality;COVID-19 prevention;COVID-19 risk;COVID-19 test;COVID-19 vaccination;Data;Development;discrete time;Disease;disease transmission;disorder control;Effectiveness;effectiveness evaluation;effectiveness testing;Epidemiologist;Epidemiology;Evaluation;evidence base;experience;feasibility testing;flexibility;Funding;Future;Goals;Government;Growth;hazard;Hazard Models;health disparity;Herd Immunity;high risk;Hospitalization;Household;improved;Individual;Infection;Infection Control;infection risk;Intervention;Jail;Knowledge;Left;marginalized population;Mass Screening;Measurable;Measures;Mentors;Methodology;Methods;microbial disease;model development;Modeling;models and simulation;Modification;Nature;novel;Output;Persons;Phase;Policies;Policy Maker;Population;Predisposition;prevent outbreaks;prevention effectiveness;Prevention Measures;Prevention strategy;Prisons;programs;Protocols documentation;Public Health Schools;Research;Respiratory Tract Infections;Risk;Risk Reduction;Role;SARS-CoV-2 infection;SARS-CoV-2 transmission;Scientist;simulation;skills;Social Distance;Social Network;Structure;symptomatic COVID-19;Testing;Time;Training;Training Programs;transmission process;treatment effect;United States;unvaccinated;Vaccinated;Vaccination;Vaccinee;Vaccines;Validation;Variant;Viral;Vulnerable Populations

PROJECT_TITLE: Identifying and evaluating prevention strategies for COVID-19 in correctional facilities

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Narrative Aging is associated with a decline in the folding and quality control capacities of cells, leading to the generation of toxic protein aggregates that lead to protein misfolding diseases. Alzheimer's disease (AD), the most prevalent form of dementia in the elderly, is strongly associated with aggregation of the amyloid beta peptide (Aβ). The proposed studies aim to establish a new method to evolve new molecular chaperones that are tailored to Aβ and to test the efficacy of the evolved chaperones in neutralizing Aβ toxicity. The results will generate a new approach to intervene in age-related protein misfolding diseases.

PI_NAMEs: SHAN, SHU-OU  (contact);WANG, XINGLONG

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: abeta accumulation;age related;age related neurodegeneration;Aging;Alzheimer's Disease;Amyloid beta-42;Amyloid beta-Protein;Amyloid deposition;amyloid formation;Animal Model;anti-toxin;Behavioral;Biochemical;Biological Models;Brain;brain dysfunction;C-terminal;Cell Aging;Cell model;Cell Survival;Cells;Chromatography;cofactor;Cognition Disorders;cognitive function;Cytoprotection;Data;Dementia;Directed Molecular Evolution;Disease;Disease Progression;efficacy testing;Elderly;Evolution;experimental study;Failure;Fluorescence;Generations;Goals;hyperphosphorylated tau;In Vitro;in vitro testing;in vivo;Infusion procedures;insight;interest;Kinetics;Link;Methods;Modeling;Molecular;Molecular Chaperones;Mus;neuroinflammation;Neurons;novel;novel strategies;novel therapeutic intervention;protein aggregation;protein aminoacid sequence;protein misfolding;Proteins;Quality Control;Research;small molecule;Specificity;System;tau Proteins;Testing;Toxic effect;Toxin;Transgenic Mice;Transmission Electron Microscopy;Up-Regulation

PROJECT_TITLE: Tailor-Made Molecular Chaperones to Target Protein Misfolding

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: Los Angeles

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Early childhood development (ECD) programs can help address early disadvantages for the 43% of children under five in low- and middle-income countries who experience compromised development, but they are too expensive to implement at scale in LMIC settings and their impacts tend to fade over time in the absence of continued support. Our study tests the relative cost-effectiveness and potential scalability of different mobile health (mHealth)-based ECD interventions that partially or fully substitute remote delivery for in-person meetings compared to a traditional in-person intervention, where all interventions last for two years. We will conduct a non-inferiority cluster Randomized Control Trial across 60 villages and 12oo households in rural Kenya using an adaptive trial design to test these different intervention delivery models.

PI_NAMEs: LOPEZ GARCIA, ITALO  (contact)

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Address;Age;aged;Behavior;Cellular Phone;Child;Child Development;Child Rearing;Clinical Trials Design;Cluster randomized trial;Cognitive;Communication;Community Health Aides;Consensus;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Country;design;Development;development policy;Disadvantaged;early childhood;Early Intervention;Educational Curriculum;Effectiveness;Emotional;Environment;Evaluation;experience;experimental study;Feedback;Goals;Group Meetings;Health;health care service;Health Services;Healthcare Systems;Household;Hybrids;implementation process;improved;Income;Intervention;intervention delivery;Kenya;Knowledge;Language;low and middle-income countries;Measures;meetings;mHealth;mhealth interventions;Modeling;Mothers;National Institute of Child Health and Human Development;nutrition;nutrition education;operation;Outcome;parenting intervention;Penetration;Personal Satisfaction;Persons;Policies;Policy Maker;Poverty;process evaluation;Program Development;programs;psychosocial;Randomized;randomized trial;Randomized, Controlled Trials;rapid growth;relative cost;relative effectiveness;remote delivery;remote intervention;Research;Resource-limited setting;Resources;Rural;rural healthcare;rural setting;Sampling;Services;Surveys;systematic review;Technology;Testing;therapy development;Time;Training;treatment arm;trial design;Work

PROJECT_TITLE: Achieving Sustained Early Child Development Impacts at Scale: a Kenyan RCT

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Striatum dopamine dysfunction is implicated in a variety of neurological and psychiatric disorders including Parkinson’s Disease, Obsessive-Compulsive Disorder, schizophrenia, and addiction. However, how dopamine release dynamics in different regions of the striatum support such diverse functions is not well understood, hindering the development of more targeted and effective treatments. This project aims to understand how spatiotemporal variations in striatum-wide dopamine reward prediction error computations contribute to different types of learning with the goal of developing a more nuanced and complete understanding of dopamine function and dysfunction.

PI_NAMEs: BROWN, ELEANOR  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: 3-Dimensional;addiction;Affect;Anatomy;Animals;Area;Association Learning;Basal Ganglia;Behavior;behavior test;Behavioral;Behavioral Model;Behavioral Paradigm;Boston;Brain region;cell type;Characteristics;Choice Behavior;Chronic;Classification;collaborative environment;Complex;Corpus striatum structure;Cues;design;Development;Devices;Diagnostic;digital;Disease;Dopamine;dopaminergic neuron;Educational process of instructing;effective therapy;Etiology;experience;Fiber;flexibility;Fostering;Functional disorder;Future;Goals;Heterogeneity;Impairment;improved;in vivo evaluation;Investigation;Learning;Light;Location;Maps;Mental disorders;Mentorship;Methodology;Methods;Modeling;Mus;Nervous System Disorder;neural circuit;Neurosciences;Obsessive-Compulsive Disorder;Operant Conditioning;optical fiber;Optics;optogenetics;Outcome;Parkinson Disease;Pattern;Photometry;postsynaptic;Process;programs;Recording of previous events;Research;Resolution;response;Response to stimulus physiology;Rewards;Schizophrenia;segregation;Shapes;Signal Transduction;Site;spatiotemporal;Stimulus;Symptoms;Techniques;technology development;Testing;tool;Traineeship;Training;Training Support;Universities;Update;Variant

PROJECT_TITLE: Establishing a Spatial Map of Dopamine Reward Prediction Error Computations and their Function in Distinct Associative Learning Processes Across the Striatum: a Methodological Framework


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The UCLA-South Africa Sustainable Academic Capacity Building for Excellence in Research Training (SACERT) builds on 14 years of research training of South African early career investigators and academic communities on chronic stress and non-communicable chronic mental health disorders including substance abuse, depression, and posttraumatic stress disorder across the life course. As an international collaboration between UCLA and 12 institutions in South Africa, including University of Cape Town, Human Sciences Research Council, Stellenbosch University, and Walter Sisulu University, SACERT’s public health mission is to: 1) increase the number of well-trained South African researchers and mentors in chronic stress and non- communicable chronic mental health; 2) translate research findings into culturally congruent substance abuse and mental health treatment interventions and programs; and 3) facilitate the building of sustainable community clinical and research capacity and university infrastructure that benefits South African people.

PI_NAMEs: KLEINTJES, SHARON ROSE;MILBURN, NORWEETA GERMAINE;SIMBAYI, LEICKNESS ;WYATT, GAIL E. (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Applications Grants;Area;Chronic;Chronic stress;Climate;Disadvantaged;Discipline of Nursing;Doctor's Degree;doctoral student;Education;Educational workshop;Environment;experience;Faculty;Goals;improved;Institution;Knowledge;Leadership;Life Cycle Stages;Master of Science;Mental Depression;Mental disorders;Mental Health;Mentors;Mentorship;Modeling;multidisciplinary;Occupational Therapy;Pathway interactions;Persons;Post-Traumatic Stress Disorders;pre-doctoral;Principal Investigator;Productivity;Psychiatry;Psychology;Public Health;Publications;Research;Research Training;residence;response;satisfaction;skills;Social Work;South Africa;South African;Substance abuse problem;Time;Training;Training Programs;Universities;virtual

PROJECT_TITLE: Sustainable Academic Capacity Building of Excellence through Research and Training Program (SACERT)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(55)R]