NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Contraception/Reproduction;Infectious Diseases;Maternal Health;Mental Health;Mental Illness;Neurosciences;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE The impact of Maternal immune activation (MIA) during pregnancy on the brain development in humans is largely unknown. We propose to use the Generation R cohort, a cohort with a large sample size and long follow-up period, to combine detailed clinical information on infections during pregnancy and inflammatory biomarkers with structural and functional brain imaging and detailed assessment of cognition, behavior and psychopathology in the adolescent offspring. While a positive association could lead to targets for prevention and aggressive treatment of infections during pregnancy, negative findings or threshold effects could provide reassurance to pregnant women and their families.

PI_NAMEs: BERGINK, VEERLE  (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: 14 year old;Adolescence;Adolescent;adolescent offspring;adverse outcome;aggressive therapy;Animal Model;Anisotropy;autism spectrum disorder;Behavior;Behavioral;behavioral impairment;Biological Markers;Bipolar Disorder;Birth;Body mass index;boys;Brain;brain abnormalities;Brain imaging;Child;Child Behavior Checklist;Chronic;Clinical;clinically relevant;Cognition;Cognitive;Cognitive deficits;cohort;COVID-19 pandemic;cytokine;Data;Development;Diffusion Magnetic Resonance Imaging;Early identification;Equipment and supply inventories;executive function;Family;Fetal Growth;Fetus;follow-up;Functional disorder;Generations;Gestational Age;girls;graph theory;High-Risk Pregnancy;Human;Hypertension;IL17 gene;IL8 gene;imaging study;immune activation;Immune response;Immunologics;indexing;Infection;Infectious Pregnancy Complications;Inflammation;Inflammatory;inflammatory marker;Intelligence;Interleukin-1 beta;Interleukin-6;Left;Long-Term Effects;Longterm Follow-up;Magnetic Resonance Imaging;maternal immune system;maternal serum;Measures;Mediating;Mediator;Negative Finding;neurodevelopment;neuropsychiatric disorder;next generation;offspring;Outcome;Output;Phase;Population Study;Pre-Eclampsia;Pregnancy;Pregnant Women;Premature Birth;prenatal;Prevention;Psychopathology;Reporting;Risk;Rodent;Sample Size;Sampling;SARS-CoV-2 infection;Schizophrenia;Series;Serum;Severities;social;Structure;Temporal Lobe;Testing;Thick;TNF gene;tractography;ultrasound;Virus;white matter

PROJECT_TITLE: The impact of prenatal maternal infection and inflammation on human brain development and psychopathology during adolescence

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE  Glaucoma is a leading cause of blindness; however, current treatment strategies are not sufficient to prevent progressive injury to specific nerve cells (called optic nerve) and continuous loss of visual function. The proposed project aims to determine the disease-causing importance of a molecule (called cFLIP) by modeling glaucoma in specific mouse strains lacking this molecule in glia (that are adjacent to nerve cells) and testing the effects on inflammatory nerve injury (that can be induced by glia). We expect that the information collected through this project will eventually help develop new treatment possibilities for millions of Americans suffering from this blinding disease and will also be useful in various other fields of medical research.

PI_NAMEs: TEZEL, GULGUN  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Adverse effects;Affect;Aging;American;anti-cancer research;Apoptosis;Apoptotic;Astrocytes;Axon;axon regeneration;Biological Response Modifiers;Blindness;CASP8 gene;Cell Death;cell type;Cells;cytokine;Data;design;Disease;Dissection;Ensure;Experimental Designs;Experimental Models;experimental study;Exposure to;Gene Targeting;Glaucoma;Glial Fibrillary Acidic Protein;Human;immune function;immunomodulatory therapies;immunoregulation;Individual;Inflammaging;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injury;insight;longitudinal analysis;Mediating;Medical Research;Methodology;Methods;Microglia;Modeling;Molecular;Molecular Analysis;Morphology;mouse model;Mouse Strains;Muller's cell;Mus;Nerve Degeneration;nerve injury;Neuroglia;neuroinflammation;neuronal cell body;neuronal survival;Neurons;neuroprotection;neurotoxic;Oligodendroglia;Optic Disk;Optic Nerve;Outcome;Pathway interactions;Phenotype;Pilot Projects;Play;prevent;Process;promoter;prospective;Protein Isoforms;Regenerative research;Regulation;Reporting;Research;response;Retina;retinal apoptosis;Retinal Ganglion Cells;Risk;Sampling;Shapes;side effect;Site;stem cells;Synapses;Testing;Therapeutic;Time;TNF gene;Toxic effect;Transcription Coactivator;treatment strategy;Tumor Necrosis Factor Receptor;Vision

PROJECT_TITLE: Modulation of Neuroinflammation in Glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative This project will apply physiological, computational, and psychophysical methods to investigate neuronal responses in two important brain areas related to attention and eye movements, and their implications on visual perception around eye movements. New hypotheses will be developed and their specific predictions will be tested. Many disorders and brain lesions produce abnormal perception around eye movements, and this project may help reveal underlying mechanisms which could lead to new therapies.

PI_NAMEs: GOLDBERG, MICHAEL E. (contact);QIAN, NING

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Area;Attention;attentional modulation;Belief;Brain;Cell model;Cells;Data;Dependence;Disease;Eye Movements;frontal eye fields;Future;Lateral;lateral intraparietal area;Lesion;Location;Maps;Measures;Memory;Methods;Modeling;Monkeys;Morphologic artifacts;Motion;Motor;neural network;Neurons;novel therapeutics;Parietal Lobe;Patients;Pattern;Perception;Physiological;Positioning Attribute;predictive modeling;Procedures;psychologic;Psychophysics;receptive field;Reporting;Resolution;response;Retina;retinal imaging;Saccades;Sampling;Signal Transduction;simulation;spatial vision;Stimulus;Testing;Therapeutic;Time;Training;Update;Visual;Visual Perception

PROJECT_TITLE: Physiological, Computational, and Psychological Approaches to Understanding Spatial Vision

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Substance Misuse

ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE  Ending the HIV epidemic within 10 years is an achievable goal but may not be possible without improving the extent to which substance use services are implemented into HIV service settings across the nation. This large-scale experiment will test the impact of an innovative strategy that was found to be highly effective and cost-effective for improving implementation of substance use services in non-HIV service settings. Both implementation outcomes and client outcomes will be examined, which is important for maximizing the public health relevance of the study’s results.

PI_NAMEs: GARNER, BRYAN R (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: addiction;Address;Affect;Alcohols;anxiety symptoms;brief intervention;Caring;Client;Climate;Clinical Trials;community organizations;Consultations;cost effective;depressive symptoms;Effectiveness;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation trial;Epidemic;experimental study;Feedback;Funding;Goals;HIV;implementation intervention;implementation outcomes;implementation research;implementation strategy;implementation/effectiveness;improved;improved outcome;innovation;Intervention;Knowledge;Measures;Mediating;medication compliance;misuse of prescription only drugs;motivational enhancement therapy;National Institute of Drug Abuse;Outcome;Performance;Persons;Pharmaceutical Preparations;practice setting;Public Health;public health relevance;Randomized;Reporting;Research;response;Rewards;Risk;Risk Behaviors;Service setting;Services;Site;substance abuse treatment;substance misuse;substance use;Substance Use Disorder;success;Technology Transfer;Testing;theories;Training;transmission process;treatment as usual;United States;Viral

PROJECT_TITLE: The Substance Abuse Treatment to HIV care (SAT2HIV-II) Project


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Services;Kidney Disease;Patient Safety;Precision Medicine;Prevention

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE  People with chronic kidney disease represent a vulnerable, high-risk population in which tailored pharmacological therapy is critical for optimal health outcomes. The proposed research will use electronic health record data from 30 million people in 6 cohorts to provide evidence regarding the risks of specific medications across the range of kidney function, thus informing the development and implementation of individualized prevention strategies to improve drug safety.

PI_NAMEs: CHANG, ALEXANDER R;GRAMS, MORGAN ERIKA (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: active comparator;Address;Adherence;Adult;Adverse effects;Albuminuria;Algorithms;Ancillary Study;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Area;Back;Benefits and Risks;Caring;Characteristics;Chronic Kidney Failure;clinical care;clinical decision support;Clinical Practice Guideline;Clinical Trials;cohort;Data;data de-identification;Data Set;Data Sources;Decision Making;Dedications;design;Development;Diabetes Mellitus;disease prognosis;Disease Progression;Dose;Drug Interactions;Drug Prescriptions;Electronic Health Record;electronic health system;Eligibility Determination;Enrollment;Evaluation;evidence base;Fire - disasters;Glean;Glomerular Filtration Rate;Glucose;Goals;Grant;Guidelines;Health;Health system;Heart failure;high risk;high risk population;Hypertension;implementation science;improved;individual patient;individualized prevention;inhibitor;inhibitor therapy;International;Investigation;Israel;Kidney;Knowledge;Marketing;Measures;Medical;medication safety;Metformin;Methods;Monitor;New York;novel;Outcome;Patient Care;patient subsets;Patients;Peptidyl-Dipeptidase A;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacologic;Phase;point of care;post-market;premature;Prevention strategy;Probability;Provider;Randomized;Recommendation;Regimen;Renal function;Research;Research Personnel;response;Risk;Risk Assessment;rosuvastatin;Sample Size;Sodium;Spironolactone;stem;Structural Models;study population;support tools;Sweden;symporter;System;Target Populations;targeted treatment;Testing;Therapeutic;Time;tool;Translating;Translations;treatment strategy;Universities;Work

PROJECT_TITLE: Maximizing The Benefit of Therapy in CKD

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE  The studies proposed in this application will enhance our understanding of phototransduction in intrinsically-photosensitive retinal ganglion cells. Any new information derived from these studies will be highly relevant to our knowledge about the normal and diseased states in human non-image and image vision.

PI_NAMEs: YAU, KING-WAI  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: absorption;Action Potentials;Automobile Driving;Axon;Brain;Brain imaging;Cells;circadian;Cyclic AMP;Cyclic GMP;Cyclic Nucleotides;density;Disease;Enzymes;Eye;fly;Grant;GTP-Binding Proteins;Human;Image;Inner Plexiform Layer;Invertebrate Photoreceptors;Investigation;Kinetics;Light;light intensity;Location;Measures;melanopsin;member;Membrane;Molecular;neural circuit;Pathway interactions;Photons;Photoreceptors;Photosensitivity;Phototransduction;Pigments;Property;Pupil light reflex;Reporting;response;Retina;Retinal Ganglion Cells;Second Messenger Systems;Signal Pathway;Signal Transduction;success;System;Time;Vertebrate Photoreceptors;Vision;Visual

PROJECT_TITLE: Melanopsin Photoreception and Signaling

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: DURHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Cells in the body can be removed by several modes of regulated cell death. However, cells need to stay alive long enough to complete their bucket list of tasks that they need to accomplish before they die. Here we study the mechanisms by which a specific cell death delaying proteins allows the cells to survive just long enough to finish critical tasks before they die.

PI_NAMEs: MIAO, EDWARD A (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: acid sphingomyelinase;Actomyosin;Adhesions;Apoptosis;Apoptotic;Bulla;Calcium;CASP1 gene;CASP3 gene;CASP7 gene;Caspase;caspase 12;Cell Death;Cell membrane;Cell Physiology;Cells;Cellular Structures;Ceramides;Cessation of life;Chemosensitization;Chromobacterium;constriction;Cytoskeleton;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Defect;Disease;Epithelial Cells;Epithelium;Exclusion;Exocytosis;Extracellular Space;Failure;Family;Generations;Grant;Granzyme;Hepatocyte;Human;Hyperactivity;In Vitro;in vivo;in vivo Model;Infection;Inflammatory;intestinal epithelium;Intestines;Left;Lipids;Listeria;Listeria monocytogenes;Listeriosis;Lysosomes;Measures;Membrane;Modeling;Molecular;monolayer;Mus;Natural Killer Cells;oral infection;Organoids;Pathologic;Pathway interactions;Peptide Hydrolases;perforin;perforin 2;Phenocopy;Phenotype;Physiological;Play;Point Mutation;Pore Proteins;Predisposition;Process;Propidium;Proteins;Publishing;repaired;Resistance;Role;Salmonella;Salmonella infections;Salmonella typhimurium;Signal Transduction;Time;VDAC1 gene

PROJECT_TITLE: Membrane repair boosted by caspase signaling

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Hematology;Mental Health;Mental Illness;Orphan Drug;Palliative Care;Pediatric;Pediatric Cancer;Post-Traumatic Stress Disorder (PTSD);Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Patients with a new diagnosis of acute myeloid leukemia (AML) confront substantial psychological symptoms as they cope with a sudden and life-threatening diagnosis that requires immediate disruption of their lives and an urgent 4-6-week hospitalization to initiate intensive chemotherapy. Despite their immense burden, interventions to address the needs of this vulnerable population are limited. This proposal seeks to assess the efficacy of a patient-centered, self-administered, digital app (DREAMLAND) for improving patient-reported quality of life and psychological distress during this challenging hospitalization for intensive chemotherapy and in the long-term.

PI_NAMEs: EL-JAWAHRI, AREEJ  (contact)

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: Acute Myelocytic Leukemia;acute traumatic stress disorder;Address;Anxiety;anxiety symptoms;Behavior Therapy;Breakthrough device;Cancer Center;cancer diagnosis;chemotherapy;Clinical;clinically significant;coping;Data;depressive symptoms;Diagnosis;digital applications;digital health;digital intervention;digital treatment;efficacy evaluation;efficacy testing;Ensure;Environment;evidence base;expectation;experience;Fatigue;Feeling hopeless;Fred Hutchinson Cancer Research Center;General Hospitals;Goals;Health Promotion;Hematologic Neoplasms;Hemorrhage;Hospitalization;improved;improved outcome;Infrastructure;innovation;Intervention;intervention effect;leukemia;Life;Massachusetts;Mediating;Mediator;medical specialties;Mental Depression;Mental Health;Modeling;Moods;Mourning;multi-site trial;National Institute of Mental Health;NCI Center for Cancer Research;Newly Diagnosed;novel;Onset of illness;Outcome;palliative;Palliative Care;Patient Care;patient oriented;Patient Outcomes Assessments;patient population;Patient-Focused Outcomes;Patients;Persons;physical conditioning;physical symptom;post-traumatic stress;post-traumatic symptoms;primary outcome;Process;Prognosis;psychoeducation;psychologic;psychological distress;psychological outcomes;psychological symptom;psychosocial;Psychotherapy;Quality of Care;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recovery;reduce symptoms;Reporting;Research;Research Priority;Self Administration;Self Care;Self Efficacy;Sepsis;Shock;side effect;Site;skills;Sleeplessness;Social isolation;Solid Neoplasm;Substance abuse problem;Supportive care;survivorship;Symptom Burden;symptomatic improvement;Symptoms;technology intervention;Testing;therapy development;treatment as usual;Uncertainty;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: Multi-Site Randomized Controlled Trial of a Novel Digital Application (DREAMLAND) to Improve Outcomes for Patients with Acute Myeloid Leukemia

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE The Leica Stellaris 5 confocal microscope will be an integral part of the Imaging Core Facility within the Department of Neurobiology and Anatomy at Drexel University College of Medicine. It will increase productivity of NIH-funded health-related projects on various areas of neuroscience including development, addiction, motor control, and injury and disease of the brain and spinal cord.

PI_NAMEs: BAAS, PETER W. (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: addiction;Aging;Anatomy;Area;Biomedical Research;career;college;Complement;Confocal Microscopy;Core Facility;Detection;detector;Development;experimental study;flexibility;Funding;Health;Height;Image;improved;injury and repair;Lasers;Light;Medicine;Microscope;Microscopy;Nerve Degeneration;Neurobiology;Neurosciences Research;novel;Productivity;programs;redshift;repaired;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Technology;United States National Institutes of Health;Universities

PROJECT_TITLE: Leica Stellaris 5 Confocal Microscope for Shared Resource Facility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Eye Disease and Disorders of Vision;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Narrative This investigation focuses on understanding how nitrogen mustard, a toxic vesicant, causes injury to corneal axons and we plan to identify FDA approved drugs to facilitate axonal regeneration.

PI_NAMEs: MOHAN, ROYCE  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acute;Address;Adopted;Affect;afferent nerve;Animal Model;Anterior;Applications Grants;arm;Axon;axon injury;axon regeneration;Bee Venoms;Bees;Biological;Biological Markers;Cell Nucleus;cell regeneration;cell type;Cells;Characteristics;chemical countermeasure;Chemical Exposure;Chemical Injury;chemical threat;Chemicals;Chronic;Clinical;Combined Modality Therapy;Cornea;corneal epithelium;Corneal Injury;corneal regeneration;Corneal Stroma;Data;Defect;Dexamethasone;DNA Damage;Dose;drug candidate;Drug Combinations;drug testing;enhanced green fluorescent protein;Epithelium;Esthesia;experimental study;exposed human population;Exposure to;Eye;FDA approved;Goals;Grant;healing;Health;Homeostasis;Immunosuppressive Agents;improved;in vivo;Inflammatory;injured;Injury;innovation;insight;Investigation;Keratopathy;Label;Limbus Corneae;mass casualty;Mechanics;Mechlorethamine;Medical;Methods;Modeling;Molecular;mouse model;Mouse Protein;Mus;Mustard Gas;Natural regeneration;Nerve;Nerve Degeneration;Nerve Endings;Neuroglia;neuronal cell body;new therapeutic target;novel;novel therapeutics;ocular pain;Operative Surgical Procedures;Organ;Pathway interactions;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Poison;preclinical development;Preparation;Process;programs;Property;Proteins;Proteolipids;Publishing;Rationalization;Rattus;Recovery;regenerative;Regimen;repaired;Reporting;Research;response;Role;Schwann Cells;Security;Sensory;single-cell RNA sequencing;small molecule;Stimulus;Sting Injury;Structure of trigeminal ganglion;Tacrolimus;Testing;Therapeutic;Therapeutic Effect;Time;Tissues;Tobramycin;Topical application;Toxin;transcriptome;Transgenic Mice;Translational Research;Translations;Treatment Efficacy;Treatment Protocols;treatment strategy;Trigeminal nerve structure;United States National Institutes of Health;Vesicants

PROJECT_TITLE: Targeting Corneal Schwann cells to counteract against toxin injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-F (54)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative  Over the past five years, we have observed an over 300% increase in the number of hours of cell sorting since 2016 and now have reached maximum capacity on 3 high-end, end-of-life cell sorters. The proposed Special Order BD FACSDiscover S8 Spectral Cell Sorter with BD CellView Image Technology will accelerate the rate of scientific discovery by providing reliable capacity and cutting- edge capabilities based on principles of high dimension spectral flow and simultaneous sort-capable imaging that is central for primary human-based cell sorting and other fields alike. Together, this machine will meet the needs of the rapidly developing translational research initiatives at Northwestern University.

PI_NAMEs: PERLMAN, HARRIS R (contact)

PROJECT_TERMS: Acute;Address;Age;Animals;base;Biological Assay;Cell Communication;Cell Cycle;Cell Separation;Cells;Color;Communities;Complex;Comprehensive Cancer Center;Core Facility;cost effective;Detection;detector;Education;empowerment;end of life;Event;Flow Cytometry;Future;high dimensionality;Hour;Human;imaging capabilities;Imaging technology;insight;instrument;instrumentation;Label;Lasers;Morphology;Patients;Process;Productivity;repaired;Research;Research Personnel;Schedule;Scientist;Services;Sorting;Specimen;System;Technology;Time;Translating;Universities;Wait Time

PROJECT_TITLE: BD FACSDiscover S8: A multi-laser spectral cell sorter with BD CellView Image Technology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-D (30)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The requested console and cryoprobe to modernize our existing 700 MHz NMR spectrometer will enable detailed studies of complex biological macromolecules in solution, including their structures, dynamics, and interactions with other macromolecules and drugs. The information that emerges from these studies will reveal fundamental new information about complex biological macromolecules and will enable the design of novel drugs for the treatment of diseases, such as neurological disorders, HIV-AIDS, cancer, and drug resistant bacterial and fungal infections.

PI_NAMEs: HINCK, ANDREW P (contact)

PROJECT_TERMS: 20 year old;Area;Biocompatible Materials;biological systems;Biomedical Research;Biomolecular Nuclear Magnetic Resonance;Biophysics;Cells;Collaborations;cryogenics;Dedications;detection sensitivity;doctoral student;experience;Failure;Funding;Institution;instrument;Joints;Label;Molecular;NMR Spectroscopy;Pennsylvania;Population Heterogeneity;Postdoctoral Fellow;programs;radio frequency;Research Personnel;Research Support;Resources;structural biology;Talents;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: 700MHZ NMR spectrometer with cryogenically cooled probe

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-V (32)]


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Chronic kidney disease is a gradual loss of kidney function, which is a major cause of morbidity and mortality in the US. Once kidney damage occurs, it results in incomplete removal of toxic products made by our microflora, termed uremic toxins, which accelerates disease progression. Chronic kidney disease is linked to changes in the composition of our microflora (dysbiosis), but it remains unclear whether these compositional changes accelerate disease progression. Successful completion of the proposed research will reveal the ecological causes of dysbiosis and determine whether dysbiosis has causative effects on chronic kidney disease progression. This information will be a critical first step for translating advances in microbiome research into clinical intervention.

PI_NAMEs: BAUMLER, ANDREAS J (contact);WINTER, SEBASTIAN E

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acceleration;Adult;Affect;American;Amines;Anaerobic Bacteria;Binding;Catabolism;Cessation of life;Chronic Disease;Chronic Kidney Failure;Clinical;Clinical Management;Colon;Data;Deterioration;Dialysis procedure;Disease Progression;dysbiosis;Ecology;Enterobacteriaceae;Environment;Escherichia coli;Excision;fecal microbiota;Genes;Gnotobiotic;Goals;Growth;gut microbiota;Hemodialysis;host-associated microbial communities;Immune response;Impairment;Indican;indoleacetic acid;Indoles;inducible gene expression;innovation;insight;interest;Intervention;Intestines;Kidney Failure;Link;Medical;member;Microbe;microbiome;microbiome research;microbiota;microbiota composition;microorganism interaction;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Nitrates;Nitric Oxide;NOS2A gene;novel;Nutritional;Outcome;Oxides;Physiological;Plasma Proteins;Population;prevent;Production;rational design;renal damage;Renal function;Research;Research Personnel;Respiration;Shapes;Sulfate;Superoxides;Testing;Toxin;Translating;Tryptophan;Uremia;Work

PROJECT_TITLE: Interspecies microbial interactions in CKD

STUDY_SECTION: IMII

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Health Services;Social Determinants of Health

ORG_CITY: LOWELL

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

PHR: Project Narrative Implicit bias is a well-documented contributor to healthcare disparities that lead to poorer health outcomes, higher infant mortality rates, and chronic disease in racial and ethnic minority populations. There exists a clear and critical need to reimagine how we approach engineering training to improve cultural competency and facilitate patient-centered, economical solutions accessible by all people regardless of race and socioeconomic status. The objective of this proposal is to establish a community- centered medical device innovation program that leads to creative, interdisciplinary problem solving of multidisciplinary engineering-nursing design teams.

PI_NAMEs: FRANCO, WALFRE  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Address;Adoption;Automobile Driving;Behavior;Biomedical Engineering;Biotechnology;Black race;Caring;Chronic Disease;Clinical;Color;commercialization;Communities;community center;community engagement;community research;community-centered;Computers;Country;Creativeness;cultural competence;Death Rate;design;Development;Device or Instrument Development;Diagnostic tests;Discipline;Discipline of Nursing;Educational Curriculum;Engineering;engineering design;Entrepreneurship;ethnic minority population;experience;Exposure to;Feedback;First Generation College Students;flexibility;Fostering;Foundations;Goals;Health;health care disparity;Health Personnel;Health Services Accessibility;Healthcare;Hispanic;hospital services;Hour;Immersion;implicit bias;improved;Incentives;Income;Incubators;Industry;Infant Mortality;innovation;instructor;Interdisciplinary Study;Learning;learning materials;Life Expectancy;marginalized population;Massachusetts;Measurable;Mechanics;Medical;Medical Device;Medical Device Designs;Medicine;member;Minority Groups;Modeling;multidisciplinary;National Institute of Biomedical Imaging and Bioengineering;Neighborhood Health Center;Nursing Students;Patient Care;patient oriented;pedagogy;peer;Persons;Pharmacologic Substance;poor health outcome;Population;Price;Problem Solving;Process;product development;Program Effectiveness;Program Evaluation;programs;Race;racial minority population;recruit;Regulation;Research;Societies;Socioeconomic Status;student retention;student training;Students;synergism;System;Thinking;Training;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States;Universities;Validation;Woman

PROJECT_TITLE: Driving community-centered medical device innovation via a longitudinal interdisciplinary immersion program

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-G (J1)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Chronic Liver Disease and Cirrhosis;Dementia;Digestive Diseases;Liver Disease;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: CLAREMONT

ORG_NAME: KECK GRADUATE INST OF APPLIED LIFE SCIS

PHR: NARRATIVE Alzheimer’s disease (AD) is the sixth leading cause of death in the United States with approximately 5.8 million Americans living with AD. Many studies show a positive association between heavy alcohol consumption and AD development and progression. Our proposal explores how chronic alcohol consumption affects the liver and brain to promote AD.

PI_NAMEs: HAN, DERICK S (contact);SUMBRIA, RACHITA

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Abeta clearance;AD transgenic mice;Affect;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol research;Alcohol-Induced Disorders;Alcoholic Liver Diseases;Alcohols;Alzheimer's Disease;Alzheimer's disease pathology;American;Amyloid beta-Protein;Area;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier permeabilization;Brain;Cause of Death;Cerebral endothelium;Chronic;chronic alcohol ingestion;Data;Deposition;Development;Down-Regulation;Etanercept;feeding;Goals;Hepatic;Homeostasis;In Vitro;in vivo;Inflammation;insight;Knowledge;Lipoprotein Receptor;Liver;Low Density Lipoprotein Receptor;Mediating;migration;Modeling;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;neurovascular;new therapeutic target;novel;Organ;Pathology;Peripheral;receptor;receptor for advanced glycation endproducts;Research;Specialist;success;synergism;tau Proteins;Techniques;TNF gene;TNFR-Fc fusion protein;United States;Work

PROJECT_TITLE: Modulation of the liver-brain axis by alcohol and its impact on Alzheimers disease pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Data Science;Hypertension;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Sleep Research

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Continuous glucose monitoring (CGM) and ambulatory blood pressure monitoring (ABPM) data are increasingly used in clinical trials, but conventional crude summaries of these data are not sufficiently sensitive for capturing possibly heterogeneous treatment effects. We will develop novel machine-learning methods to improve the characterization of CGM and ABPM data features. Developing innovative approaches for the analysis, and interpretation of digital health data for precision phenotyping of glycemic and cardiovascular measures is relevant to NHLBI's objective of leveraging emerging opportunities in data science to open new frontiers in heart, lung, blood, and sleep disorders research.

PI_NAMEs: GAYNANOVA, IRINA  (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Address;Adverse effects;Algorithmic Software;Algorithms;Ambulatory Blood Pressure Monitoring;Behavior Therapy;blood glucose regulation;Blood Pressure;Blood Pressure Monitors;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Characteristics;Clinical Trials;clinically relevant;computerized tools;Continuous Glucose Monitor;Control Groups;Data;Data Analyses;data complexity;Data Science;Development;digital health;digital phenotyping;experience;frontier;Glucose;glucose metabolism;Goals;Health;Health Benefit;health data;Heart Diseases;Heart Rate;Hematological Disease;Heterogeneity;Hyperglycemia;Hypertension;improved;indexing;innovation;Learning;learning strategy;Link;Lung Diseases;machine learning method;Measurement;Measures;Metabolic;Metabolic dysfunction;metabolic phenotype;Metabolic syndrome;Methods;Modality;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;Obstructive Sleep Apnea;Participant;patient subsets;Patients;Pharmaceutical Preparations;Phenotype;Population;positive airway pressure;Prediabetes syndrome;pressure;Prevention;Primary Prevention;randomized, clinical trials;Reporting;Research;Research Personnel;Secondary Prevention;Sleep Apnea Syndromes;Sleep Disorders;software development;Software Tools;statistical and machine learning;statistical learning;Testing;Time;treatment effect;treatment group;Variant;wearable data

PROJECT_TITLE: New machine learning methods for extracting features from digital health data with applications to sleep apnea

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative: This proposal is to fund a complete refurbishment of the McLean Hospital 9.4T / 400 mm Tesla Agilent Pre-clinical Magnetic Resonance Imaging system; this scanner is the only actively shielded 400 mm pre-clinical magnet in the world and provides imaging from mice through large NHP for the McLean and Boston area research communities. We routinely employ functional magnetic resonance imaging, morphometric imaging and 1H and 31P spectroscopy to study a wide range of psychiatric and substance abuse disorders. This upgrade will keep this scanner at the forefront of the field and will offer new opportunities for rapidly translating discoveries made in animal species to humans.

PI_NAMEs: FREDERICK, BLAISE DEBONNEVAL (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: 15 year old;Age;Animals;China;Communities;Dependence;Development;Electronics;Equipment;Failure;Functional Magnetic Resonance Imaging;functional MRI scan;Funding;Future;Hospitals;Human;Image;imaging system;instrument;Macaca;Magnetic Resonance Imaging;Mechanics;Methods;Motivation;Mus;Names;nonhuman primate;pre-clinical;Productivity;prototype;Research;Rodent;Scanning;Services;spectroscopic imaging;Spectrum Analysis;System;Technology;Time;Translating;two-dimensional;vibration

PROJECT_TITLE: Electronics and Gradients Upgrade for an Agilent 9.4T/400mm Pre-clinical MR System

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (31)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Nanotechnology

ORG_CITY: SEATTLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Recognizing challenges in people living with HBV and HIV needing to take daily pills for virus- free survival, this research has potential to bring about a transformative change in the outlook for individual living with viral hepatitis and carry the risk of liver cancer. The research on user preference and contributions of industry partners will help bring about a long-acting outcomes for patients dealing with HBV pill fatigue.

PI_NAMEs: HO, RODNEY J.Y. (contact);KIM, HYANG NINA

PROGRAM_OFFICER_NAME: PROTOPOPOVA, MARINA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;anti-hepatitis B;Anti-viral Agents;Anti-viral Therapy;Binding;Biological Assay;biomaterial compatibility;Characteristics;Chemicals;Chronic;Cirrhosis;Clinical;clinical development;clinical translation;Communities;Complex;Contractor;Data;design;Development;Dosage Forms;Dose;Drug Combinations;drug distribution;Drug Kinetics;Drug Stability;Ensure;Evaluation;Excipients;Exhibits;Fatigue;Formulation;Foundations;Goals;Hepatitis;Hepatitis B;Hepatitis B Infection;Hepatitis B Therapy;HIV;HIV therapy;improved;In Vitro;in vivo;Individual;industry partner;Injectable;innovation;Institution;Lead;Lipids;Malignant neoplasm of liver;manufacture;Measurable;Modeling;Molecular;nanoparticle;nonhuman primate;novel;Oral;Outcome;Outcome Study;particle;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetic model;pharmacologic;pill;pre-clinical;preclinical development;preference;Primates;Process;Provider;public-private partnership;Rattus;Research;Resources;response;Risk;risk mitigation;study characteristics;Subcutaneous Injections;success;technology platform;Testing;therapeutic candidate;therapy outcome;timeline;Toxicokinetics;Translational Research;Translations;United States National Institutes of Health;Viral;Viral hepatitis;Viral Physiology;viral rebound;Virus;Woodchuck

PROJECT_TITLE: Long-acting Antiviral Treatment for HBV

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ORG_CITY: CLEVELAND

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE We propose to purchase a new Iconeus One functional ultrasound (fUS) neuroimaging system which provides an ultra-fast, high-resolution system for imaging of brain anatomy, vasculature, and function. The system will be the first in the greater Cleveland area and will advance numerous ongoing projects in brain imaging, neural engineering, deep brain stimulation, neurodegenerative diseases, pain, and development of theranostics for neuro-oncology from 16 Major Users.

PI_NAMEs: EXNER, AGATA A (contact)

PROJECT_TERMS: Advisory Committees;Animals;Area;awake;Blood Vessels;Brain imaging;cerebral blood volume;Cerebrovascular Circulation;Cerebrovascular system;Clinic;Clinical;cost;Data;Deep Brain Stimulation;design;Development;Engineering;experience;experimental study;Faculty;Foundations;Functional Magnetic Resonance Imaging;Goals;Health;Human;imaging capabilities;imaging modality;improved;Institution;instrument;Magnetic Resonance Imaging;Maintenance;Medical center;Methods;Morphology;Mus;Nervous System Disorder;neural;neuro-oncology;Neurodegenerative Disorders;neuroimaging;optical imaging;Pain;Performance;Play;policy recommendation;Positron-Emission Tomography;pre-clinical;Rattus;Research;Research Personnel;Resolution;Site;System;Technology;theranostics;Translating;ultrasound;United States Department of Veterans Affairs;Universities;University Hospitals;Visualization;Work

PROJECT_TITLE: Functional Ultrasound (fUS) Neuroimaging System

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-M (30)]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: AMES

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Project Narrative Exposure to organophosphate nerve agents (OPNAs) causes acute seizures and brain injury in the long term. The current medical countermeasures are inadequate to prevent seizures-induced brain injury and its mechanisms are not well known. We, therefore, investigate the molecular mechanisms of brain injury to identify novel therapeutic targets for neuroprotection and disease-modification in the rat OPNA model.

PI_NAMEs: THIPPESWAMY, THIMMASETTAPPA  (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Acute;Affect;Amygdaloid structure;Atropine;Benzodiazepines;Binding;Binding Sites;Biological Assay;Biological Markers;Brain;Brain Injuries;Brain Pathology;Brain region;Cells;Cerebrospinal Fluid;Co-Immunoprecipitations;Complex;Cyclin-Dependent Kinase 5;cytokine;Cytosol;Data;Detection;Development;Devices;Disease;drug discovery;effective therapy;Epilepsy;epileptiform;Experimental Models;Exposure to;Family;Funding Mechanisms;Future;Gliosis;global health;Health;Hippocampus;Hour;Human;Immunohistochemistry;Implant;Individual;Inflammatory;inhibitor;Intervention;intervention effect;Isoflurophate;Knock-out;Ligation;Light;MAPT gene;Mediating;medical countermeasure;Membrane;Mission;Modeling;Modification;Molecular;mortality;Motor Cortex;nerve agent;Nerve Degeneration;neural;neurofilament;Neuroglia;neuroinflammation;Neurons;neuroprotection;new therapeutic target;novel;novel therapeutics;Nuclear;Organophosphates;Oximes;Pathogenesis;Pathway interactions;Patients;Peptides;Peripheral;Persons;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;piriform cortex;Poisoning;postsynaptic density protein;prevent;Production;programs;promoter;protective pathway;Protein Tyrosine Kinase;Protein-Serine-Threonine Kinases;Rattus;Recurrence;response;Rodent Model;Role;roscovitine;Seizures;Serine;Serum;Signal Pathway;Signal Transduction;Signaling Molecule;Soman;src-Family Kinases;Status Epilepticus;Stress;Surface;Survivors;Synaptic plasticity;Synaptosomes;targeted treatment;tau interaction;tau Proteins;tau-1;tau-protein kinase;Telemetry;Testing;Thalamic Nuclei;therapeutic development;Threonine;Time;Toxic effect;Up-Regulation

PROJECT_TITLE: Mechanisms of Neurodegeneration in a Nerve Agent Model


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The research proposed here, which requires high-sensitivity state-of-the-art biophysical spectroscopic technique to enable the study of protein structure and functional dynamics, will lead to a better mechanistic understanding of a variety of physiological and disease processes. It will also contribute to the development of novel antibiotics and cancer therapeutic agents, and to the design of safer and more effective drugs targeting a broad spectrum of diseases. Additional avenues of research are expected to be uncovered once the success of the initially proposed projects is evident, fostering further opportunities for new interdisciplinary science.

PI_NAMEs: DASTVAN, REZA  (contact)

PROJECT_TERMS: Advisory Committees;Amplifiers;anti-microbial peptide;Basic Science;Biochemistry;biomacromolecule;Biophysics;Blood coagulation;cold temperature;Communities;Complex;Data Analyses;DNA Repair;experience;Funding;Genetic Recombination;graduate student;Grant;immunothrombosis;instrument;instrumentation;Ion Channel Gating;Ligands;Link;Measures;medical schools;member;Membrane Proteins;Membrane Transport Proteins;Methods;Minor;Missouri;Modeling;Molecular Biology;Molecular Conformation;nanometer;operation;Peptide Transport;Physiologic pulse;Physiological;Postdoctoral Fellow;Preparation;Process;protein function;protein oligomer;Protein Secretion;protein structure;Proteins;Regulation;Research;Research Personnel;Resolution;Sampling;Schedule;Spectrum Analysis;student training;System;Techniques;Technology;Time;Training;Translations;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: High Q Technologies FATHOM Pulse EPR Spectrometer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-D (30)]


ORG_CITY: Chicago

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Updating Ultrasound Imaging Instrument at University of Illinois at Chicago PROJECT NARRATIVE  High-speed and high-resolution ultrasound imaging provides sensitive and dynamic detections of anatomical architectures and physiological functions in small animal models for researching human biology and disease. To sustain and expand the high volumes of productive basic and translational research at the University of Illinois at Chicago (UIC), we seek support for a VisualSonics Vevo F2 high-resolution 4- dimensional small animal ultrasound imaging system. This instrument will replace an end-of-life Vevo 2100 system to update a crucial core facility that supports multiple NIH-funded research programs at UIC.

PI_NAMEs: JIN, JIAN-PING  (contact)

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Anatomy;Animal Experimentation;animal facility;Animal Model;Architecture;Basic Science;Biological;Cardiovascular system;career development;Chicago;college;Computer software;Contract Services;cost;cost effective;Data;Dedications;design;Ensure;Equipment;Funding;Generations;Grant;Human Biology;human disease;human model;Illinois;image processing;imager;Imaging Device;improved;Institution;instrument;Laboratories;Longitudinal Studies;Maintenance;Manufacturer;Medicine;Minor;Mission;Modeling;operation;Penetration;Phase;Physiological;pre-clinical;Productivity;programs;Recovery;Reproducibility;Request for Proposals;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;Services;Speed;System;Time;Tissues;tool;Training;Translational Research;Ultrasonography;ultrasound;United States National Institutes of Health;Universities;Update;Wages

PROJECT_TITLE: Updating Echocardiograph Imaging Instrument at University of Illinois Chicago


PHR: PROJECT NARRATIVE This application supports the purchase of a next-generation 7 Tesla whole-body human MRI scanner at the Athinoula A. Martinos Center for Biomedical Imaging to replace our 22-year-old prototype 7 Tesla scanner that will soon be decommissioned. The new instrument – a Siemens Terra.X 7 Tesla scanner – will support at least 20 NIH-funded investigators at the Martinos Center and the greater Boston area community. This whole-body MRI scanner is designed to function with a next-generation removable positron emission tomography (PET) camera with an order of magnitude improvement in PET sensitivity, thereby serving both the ultra-high field MRI and PET imaging communities.

PI_NAMEs: BILGIC, BERKIN  (contact)

PROJECT_TERMS: Area;base;biomedical imaging;Boston;Brain;Brain Mapping;Central Nervous System;Clinical;Cognitive;Communities;Computer software;Computers;Custom;density;design;Development;Funding;Future;General Hospitals;Generations;Grant;Human;Human body;Image;image reconstruction;improved;Industrialization;innovation;instrumentation;Knee;magnetic field;Magnetic Resonance Imaging;Maintenance;Manufacturer;Massachusetts;multi-site trial;Neurosciences;next generation;novel;Nuclear;Performance;Pharyngeal structure;Physiologic Monitoring;Positron-Emission Tomography;programs;prototype;radio frequency;reconstruction;Research;Site;Skeletal Muscle;Spectrum Analysis;Spinal Cord;Standardization;Support System;System;technology research and development;temporal measurement;Translational Research;transmission process;United States National Institutes of Health

PROJECT_TITLE: Next-generation Upgrade for 7T Human MRI System


NIH_SPENDING_CATS: Back Pain;Chronic Pain;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: CINCINNATI

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: NARRATIVE The proposed study investigates the role of the nuclear receptor subfamily 4, group A, member 1 (NR4A1) in pain resolution, and aims to provide a translational validation of NR4A1 as a new, non-addictive, therapeutic target for postoperative pain and low back pain, two pain conditions at high risk of opioid abuse. Additionally, the study will reveal SPP1 as a novel biological and functional biomarker for future testing and improve of multiple NR4A1 agonists aiming to prevent and treat chronic pain.

PI_NAMEs: BERTA, TEMUGIN  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: 3-Dimensional;abuse liability;Acceleration;Address;Affective;Agonist;Analgesics;Animal Model;Antibodies;Applications Grants;Back Pain;Behavioral Assay;Biochemical;Biological;Biological Markers;Chronic;chronic pain;chronic pain management;conditional knockout;cytokine;Data;Dexamethasone;Disease;Electrophysiology (science);experimental study;FDA approved;Flow Cytometry;Funding Opportunities;Future;Grant;Health;Helping to End Addiction Long-term;high risk;Homeostasis;Human;human tissue;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Knock-out;Knockout Mice;Laboratories;Low Back Pain;Macrophage;Measures;Mediator;Modeling;monocyte;Morphine;mouse model;Mus;Neurodegenerative Disorders;Neuroimmune;Neuroimmunomodulation;neuronal excitability;Neurons;Neuropathy;novel;novel marker;NR4A1 gene;opioid abuse;opioid epidemic;opioid misuse;osteopontin;Pain;Pain management;pain model;Peripheral;pharmacologic;Phase;Play;Postoperative Pain;Postoperative Period;postoperative recovery;prevent;Protein Secretion;Radiculopathy;Rattus;Recombinant Proteins;Recovery;Reflex action;Reporter;Resolution;response;restoration;Rewards;Role;Serum;Signal Transduction;Skin Tissue;small molecule;Societies;Surgical incisions;Testing;Therapeutic;therapeutic target;Tissues;Transgenic Mice;translational potential;Validation;validation studies;Visualization

PROJECT_TITLE: Cellular Mechanisms and Therapeutic Potential of NR4A1 in Pain Resolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-Z (55)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Transplantation of engineered heart tissues offers great potential to repair and regeneration of the damaged myocardium. This project will establish the safety and efficacy of a novel electrically conductive and functional engineered heart tissue in preclinical translational animal models, which could aid in clinical trials in treating patients with heart injuries.

PI_NAMEs: NIKKHAH, MEHDI ;ZHU, WUQIANG  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Acute;Acute myocardial infarction;Address;Adult;angiogenesis;Animal Model;Animals;Area;Arrhythmia;Attention;Behavior;Biocompatible Materials;Biological;Biological Assay;Cardiac;cardiac angiogenesis;Cardiac Myocytes;cardiac regeneration;cardiac tissue engineering;CCND2 gene;Cell Line;Cell Maturation;Cell Proliferation;Cells;cellular engineering;Chronic;Cicatrix;Clinic;Clinical Trials;clinically relevant;Coculture Techniques;Congestive Heart Failure;coronary fibrosis;Coupling;Cues;disease model;Echocardiography;Electric Conductivity;Electric Stimulation;Electrophysiology (science);Endothelial Cells;engineered stem cells;Engineering;Engraftment;Exhibits;Family suidae;Fibroblasts;follow-up;Functional disorder;Gelatin;Generations;Genetic Engineering;Goals;Heart;heart function;Heart Injuries;heart rhythm;hemodynamics;Histology;Human;Human Engineering;human induced pluripotent stem cells;Hydrogels;Immunocompromised Host;immunosuppressed;Implant;improved;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Infarction;injured;Ischemia;Ligation;Magnetic Resonance Imaging;Maps;Measurement;Mechanics;Methacrylates;Modeling;Monitor;Morbidity - disease rate;mortality;mouse model;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;Myosin Heavy Chains;nanoengineering;nanoGold;nanomaterials;nanorod;Natural regeneration;novel;novel strategies;novel therapeutic intervention;Nude Rats;Optics;Organ;overexpression;Patients;porcine model;pre-clinical;Predisposition;progenitor;Proliferating;promoter;Rattus;regeneration model;regenerative;Regenerative capacity;repaired;Reporter;Resistance;Risk Reduction;Safety;Series;Smooth Muscle Myocytes;stem;stem cell therapy;Stem cell transplant;stem cells;Surface;Techniques;Technology;Time;Tissue Engineering;tissue regeneration;Tissue Transplantation;Tissues;Transgenes;translational impact;Transplantation;tumor;Ventricular Cardiac alpha-Myosin;Work

PROJECT_TITLE: Electrically Conductive Stem Cell Derived MicroEngineered Heart Tissue for Regeneration of Injured Myocardium

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative A new and promising treatment for antibiotic-resistant bacterial infections is phage therapy, in which the viruses (bacteriophages) that normally infect bacteria are used to eradicate specific pathogens. The long-term success and efficacy of such efforts depend critically on a deeper, more complete understanding of how bacteria can respond to and evade infection by bacteriophages. This work focuses on the development and application of a powerful, large-scale functional screening approach to rapidly pinpoint the anti-phage defenses systems in a diverse collection of 1,500+ E. coli strains, including many pathogenic strains.

PI_NAMEs: LAUB, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Address;Antibiotic Therapy;arms race;Bacteria;Bacterial Antibiotic Resistance;Bacterial Genome;Bacterial Infections;Bacteriophages;Biochemical;Bioinformatics;Biology;Case Study;Categories;Cells;cellular engineering;Clustered Regularly Interspaced Short Palindromic Repeats;Coliphages;Collection;Computer Analysis;computer studies;Conflict (Psychology);deep sequencing;Defense Mechanisms;Detection;Development;Distant;Elements;Escherichia coli;ESKAPE pathogens;experimental study;Foundations;Future;Generations;Genes;Genetic Engineering;genome editing;Genomic Library;Genomics;Grant;Homologous Gene;Horizontal Gene Transfer;human pathogen;Immune system;Immunity;Individual;Infection;Innate Immune System;insight;interest;invention;Island;Libraries;Life;Lytic;Maps;Methodology;Methods;Modernization;Modification;Molecular;Molecular Biology;Morphology;Natural Immunity;next generation;novel;novel strategies;novel therapeutics;Organism;pan-genome;pathogen;pathogenic bacteria;Pathogenicity;Procedures;Proteins;Public Health;Reporting;restriction enzyme;screening;success;System;Therapeutic;Therapeutic Agents;Therapeutic Uses;tool;United States;virtual;Virus;Virus Diseases;Work

PROJECT_TITLE: Systematic identification of novel anti-phage defense mechanisms in the E. coli pangenome

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Health Services;Patient Safety;Rural Health;Social Determinants of Health

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: NARRATIVE We are developing a new training program for biomedical engineering (BME) students that will cultivate their Engineering Habits of Mind (EHoM) and serve as a bridge to a career in medical device research and development (R&D). This experiential learning (EL) opportunity will consist of a clinical immersion conducted in rural and urban healthcare facilities to identify unmet medical needs with a focus on understanding the social determinants of health (SDoH) and promoting health equity. In parallel, student teams will build prototyping skills by working on existing R&D projects to improve healthcare with our clinical partner and lead design, fabrication, and proof-of-concept testing through simulated use verification and validation activities.

PI_NAMEs: ARENA, CHRISTOPHER B (contact)

PROJECT_TERMS: Academic Medical Centers;Acceleration;Active Learning;Address;Area;Articulation;Attention;Back;Beds;Biological Sciences;Biomedical Engineering;career;Clinic;Clinical;clinical care;clinical research site;Collaborations;college;commercialization;Communities;Community Hospitals;Competence;County;Custom;database design;Databases;design;Development;Development Plans;Discipline of Nursing;Economics;Ecosystem;Education;Elements;Employment;Engineering;Entrepreneurship;Environment;experience;Exposure to;fabrication;Facility Accesses;Faculty;Future;Generations;Growth;Habits;Health;health assessment;Health care facility;health care service organization;health disparity;health equity;health equity promotion;Health Service Area;Health Services Accessibility;Healthcare;Hospitals;Immersion;improved;Industry;innovation;Integrated Health Care Systems;invention;Knowledge;knowledge base;Lead;Learning;Legal patent;lens;Letters;Maintenance;manufacture;manufacturing technology;Marketing;Medical;Medical Device;medical schools;medical specialties;Mentors;Methods;Mind;Modeling;Morbidity - disease rate;mortality risk;multitask;new technology;open-ended problem;Operative Surgical Procedures;Outcome;Pain;Participant;Patient Care;patient safety;Patients;pedagogy;peer;Phase;Physical environment;Positioning Attribute;Preparation;Primary Care;Procedures;Process;product development;professional students;programs;prototype;Provider;recruit;Regulation;Research;research and development;Research Design;Research Methodology;Research Project Grants;Rural;Rural Health;rural patients;Self-Examination;simulation;skills;Social Environment;social health determinants;Social Responsibility;Students;Surveys;symposium;System;Talents;task analysis;Technology;Technology Transfer;Testing;Thinking;Time;timeline;tool;Training;Training Programs;Trauma;undergraduate student;Universities;Urban Health;usability;verification and validation;Virginia;Visit;Work

PROJECT_TITLE: Biodesign for Health Equity


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Bioengineering;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Approximately three million people are exposed to acute organophosphate poisoning every year world-wide. Due to a lack of research tools available, there is still a lack of knowledge surrounding the molecular short- and long-term effects of acute organophosphate intoxication. We propose the use of a novel mouse model and matrix assisted laser desorption ionization mass spectrometry imaging to study these effects.

PI_NAMEs: TRESSLER, CAITLIN  (contact)

PROJECT_TERMS: Accidents;Acetylcholine;Acetylcholinesterase;Active Sites;Acute;Adult;Affect;Age;Animal Model;Animals;Atropine;Binding;Birth;Blood;Brain;carboxylesterase;Cavia;Cessation of life;Chemicals;cholinergic;Cognitive;Control Animal;Data;density;Elderly;Embryo;esterase;Euthanasia;Event;ex vivo imaging;experience;experimental study;Exposure to;Female;Freezing;Generations;Genetic;Heart;Histology;Hour;Human;human model;Image;imaging modality;improved;in utero;instrumentation;Intoxication;Ions;Kinetics;Knock-in;Knock-out;Knowledge;Lethal Dose 50;Life;Lipids;Literature;Long-Term Effects;male;Malignant Neoplasms;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Measures;Medical Research;medical schools;middle age;Modification;Molecular;molecular imaging;Mood Disorders;Morphology;Mothers;mouse model;Mus;nerve agent;neuroinflammation;Neurologic;Neurotransmitters;novel;offspring;organophosphate poisoning;Organophosphates;oxidation;Oxidative Stress;Pathology;Peptides;Persons;Pharmaceutical Preparations;Polysaccharides;Predisposition;Pregnancy;pregnant;prevent;Proteins;Reactive Oxygen Species;Reproducibility;Research;Research Institute;Research Personnel;Resolution;Resources;Rodent Model;Running;Sarin;Serum;side effect;small molecule;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Speed;Spinal Cord;Stains;standard of care;Structure;System;Technology;Terrorism;Testing;Time;Tissues;tool;toxic organophosphate insecticide exposure;Water;Work

PROJECT_TITLE: MALDI Imaging of Acute Organophosphate Exposure in KIKO Mice


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Rapid and cost-effective whole genome sequencing, methylation profiling, single-cell and spatial genomics is now possible with the Illumina NovaSeq X Plus. This technology will enable deeper insights into genetic and epigenetic regulation as well as disease progression.

PI_NAMEs: HERBERT, ZACHARY T (contact)

PROJECT_TERMS: Applications Grants;Base Pairing;Core Facility;cost;cost effective;Dana-Farber Cancer Institute;Economics;Funding;genome sequencing;Genomics;High-Throughput DNA Sequencing;Improve Access;instrument;manufacturing systems;Methylation;Molecular Biology;next generation sequencing;Proteomics;Request for Proposals;Services;single cell genomics;System;Technology;Time;transcriptomics;whole genome

PROJECT_TITLE: High-Throughput DNA Sequencing System


NIH_SPENDING_CATS: Breast Cancer;Cancer;Microbiome;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Breast-resident microbes are proposed to be largely attributed to translocation of gut microbes and play critical roles in regulation of breast pathophysiology; however, t here have been mostly correlative and speculative studies for the roles and origins of breast microbiota. The proposed project aims to substantiate the direct roles of breast microbiota in breast pathophysiology. The proposed study is relevant to public health because it will justify a new breast cancer treatment or prevention strategy focused on breast microbiota.

PI_NAMEs: FURUTA, SAORI  (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Animals;Antibiotics;antitumor effect;Arginine;Bacteria;Breast;Breast Cancer Model;Breast Cancer Treatment;Cancer Patient;carcinogenesis;Cells;cofactor;cohort;Development;Dimethyl Sulfoxide;Disease;Distant;ERBB2 gene;Female;Fluorescence;Functional disorder;Goals;gut bacteria;gut microbes;gut microbiota;Harvest;Health;Hormones;host microbiota;Human Milk;Immune;immunogenicity;improved;innovation;Label;Macrophage;Malignant Neoplasms;Mammary gland;Mammary Gland Parenchyma;Mammary Neoplasms;Mediating;Metabolism;Microbe;microbiome;microbiome research;microbiota;microbiota transplantation;Mouse Mammary Tumor Virus;Mucous Membrane;Mus;Natural Killer Cells;Nitric Oxide;Nitric Oxide Synthase;Oral;Pharmaceutical Preparations;Pharmacotherapy;Play;Predisposition;Pregnancy;prepuberty;prevent;Prevention;Prevention strategy;Public Health;Regulation;Reporting;Research;Role;sepiapterin;Source;Testing;tetrahydrobiopterin;Time;Tissues;translational impact;Transplantation;treatment effect;Treatment Efficacy;treatment strategy;tumor;Tumor Burden;tumor growth;Tumor Immunity;tumor microbiota;Visualization

PROJECT_TITLE: Roles of gut-breast axis in breast pathophysiology

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE We have recently established that standard immune checkpoint therapies targeting PD-1, alone or in combination with targeting either anti-CTLA-4 or anti-LAG-3, can result in the hyperprogression of renal malignancies driven by loss of the SMARCB1 tumor suppressor gene. In the proposed project, we will harness our unique collection of longitudinally collected patient tissue samples and robust preclinical models to elucidate the mechanisms driving hyperprogression and inform the next generation of immunotherapeutic strategies for SMARCB1-deficient renal malignancies.

PI_NAMEs: MSAOUEL, PAVLOS  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Acceleration;Address;Adolescent and Young Adult;African ancestry;Aggressive Clinical Course;anti-CTLA4;anti-PD-1;anti-tumor immune response;Automobile Driving;Behavior;Biological;Budgets;Cells;checkpoint inhibition;checkpoint therapy;Chromatin Remodeling Factor;Clinical Engineering;Clinical Trials;Collecting Ducts of Bellini Carcinoma;Collection;Complex;CTLA4 gene;Cytotoxic Chemotherapy;Data;data modeling;Dedications;Diagnosis;Disease;EP300 gene;experimental study;Genetic;Genetic Transcription;Genetically Engineered Mouse;Grant;immune activation;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;immune resistance;Immunocompetent;Immunogenomics;Immunotherapeutic agent;Immunotherapy;improved;Individual;Infrastructure;inhibitor;innovation;insight;Interdisciplinary Study;Kidney;Kidney Neoplasms;Knock-out;Malignant Neoplasms;member;Modeling;Myelogenous;neoplastic cell;next generation;novel therapeutic intervention;novel therapeutics;Oncogenic;Pathway interactions;Patients;pharmacologic;Phenotype;Pre-Clinical Model;prevent;programmed cell death protein 1;programs;prospective;Recovery;Regimen;Renal Carcinoma;Renal Cell Carcinoma;Resistance;response;Retrieval;Role;S100A9 gene;Sickle Cell Trait;Signal Transduction;SMARCB1 gene;Specimen;standard of care;Sucrose;targeted treatment;Technology;Therapeutic;therapy resistant;timeline;Tissue Sample;Tissues;translational genomics;translational pipeline;translational study;tumor;tumor progression;Tumor Suppressor Genes;Tumor Suppressor Proteins;Tumor Tissue;tumor-immune system interactions;Work

PROJECT_TITLE: Mechanisms of Hyperprogression to Immunotherapy in SMARCB1-Deficient Renal Malignancies

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Colorectal Cancer;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative: Colon cancer is characterized by a prominent dynamic interaction between host and gut microbes through secondary metabolites such as bile acids, which has been shown to promote tumor initiation and progression, facilitate inflammation and reshape the gut microbiota community. The research proposed here aims to better understand how tumor risk factors including diet, inflammation and gut microbiota converged on BAs-FXR axis and modulate macrophage intrinsic responses to intestinal inflammation and tumor growth. This integrative approach to interrogate this dynamic host immune landscape with host-and-microbe communicating metabolites will shed light on not only the etiology of colitis-induced colon cancer, but also identify new therapeutic targets and biomarkers.

PI_NAMEs: FU, TING  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: 3-Dimensional;Acids;Affect;Agonist;Animal Testing;anti-cancer;Anti-Inflammatory Agents;Bile Acids;Bone Marrow Transplantation;Cancer Etiology;cancer therapy;cell type;Cells;Colitis;Colitis associated colorectal cancer;Colon Carcinoma;Colorectal Cancer;Combined Modality Therapy;Communication;Communities;cytokine;Data;Dependence;Development;Diagnosis;Diarrhea;Diet;dietary;Disease Progression;Early Diagnosis;Environmental Risk Factor;Epithelial Cells;epithelial repair;Epithelium;epithelium regeneration;Etiology;FDA approved;Genes;Genetic;Genetic Transcription;gut inflammation;gut microbes;gut microbiome;gut microbiota;Homeostasis;IL17 gene;Immune;immune modulating agents;Immune response;Immunomodulators;immunoregulation;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;intestinal epithelium;Intestinal Neoplasms;Intestines;Lesion;Ligands;Link;Macrophage;Maintenance;Malignant - descriptor;Mediating;Mediator;Metabolism;Microbe;microbial;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;novel therapeutics;Pathologic;Patients;Pharmaceutical Preparations;pharmacologic;Physiology;Production;programs;Rag1 Mouse;receptor;Receptor Signaling;Regulation;Research;response;Risk Factors;Role;secondary metabolite;sensor;Sentinel;Shapes;small molecule;Sorting;stem cell growth;stem cells;T-Lymphocyte;Testing;Therapeutic;therapeutic biomarker;transplant model;Treatment Efficacy;Treatment Protocols;tumor;tumor growth;tumor initiation;tumor progression;Tumor Promotion;tumorigenesis;Ulcerative Colitis

PROJECT_TITLE: The regulation of gut macrophage’s function by the bile acid receptor FXR


NIH_SPENDING_CATS: Biotechnology;Cancer;Rare Diseases

PHR: PROJECT NARRATIVE High-parameter cytometry and in-depth imaging analysis can yield critical insights into the complexities of biological processes, diseases, and treatments. By evaluating both suspended and tissue biospecimens with measurements of 40+ protein features at once with high customizability and in a relatively cost-effective manner, mass cytometry as a unique discovery platform has been significantly empowering multiple key research efforts at Johns Hopkins University. Leveraging the current infrastructure of Johns Hopkins Mass Cytometry Facility, this proposal seeks to fund a CyTOF XT as the second mass cytometer to meet the rapidly growing demands in a wide-breadth of NIH-funded research activities including multiple cancer research programs, bioengineering, computational biology, and dermatology at Johns Hopkins.

PI_NAMEs: HO, WON JIN  (contact)

PROJECT_TERMS: Acceleration;Biology;Biomedical Research;career;cell type;Cells;Cellular biology;Communities;Comprehensive Cancer Center;Computational Biology;Cytometry;Data;Dermatology;experience;Fluorescence;Funding;Future;Generations;Image;Infrastructure;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of pancreas;medical schools;Minor;operation;Pathology;Process;programs;Research;Research Activity;Research Personnel;Research Support;Resource Sharing;Science;Services;Suspensions;System;Techniques;Tissues;tool;United States National Institutes of Health;Universities

PROJECT_TITLE: Mass Cytometer CyTOF XT for Single-Cell Biology


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Acquisition of a modern 800 MHz NMR spectrometer will provide essential new capabilities in high throughput fragment-based drug discovery, 19F NMR, and NMR-based structural biology to six major users and many minor users at Vanderbilt University, supported by NIH funding. It will extend essential capabilities in basic and translational biomedical research and training. It will be used for probing biomolecular binding interactions, and structural and dynamics studies of complex biological macromolecules.

PI_NAMEs: STONE, MICHAEL P (contact)

PROJECT_TERMS: Binding;Biological;Biomedical Research;Biomolecular Nuclear Magnetic Resonance;Complex;Dedications;drug discovery;Drug Screening;Faculty;Funding;Helium;Institution;instrumentation;Laboratories;macromolecule;Methods;Minor;NMR Spectroscopy;operation;Phase;Postdoctoral Fellow;pre-doctoral;Preparation;Research;Resolution;Sampling;Science;Site;structural biology;Training;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities

PROJECT_TITLE: Acquisition of an 800 MHz NMR


ORG_NAME: UNIVERSITY OF HOUSTON

PHR: Project Narrative/ Public Health Relevance Statement This proposal aims to determine the structure, functions, mechanisms, and genetics of a newly discovered nanotube-like structure named signaling bridge during cardiac morphogenesis.

PI_NAMEs: WU, MINGFU  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: 3-Dimensional;Actins;Applied Genetics;Area;Bacterial Artificial Chromosomes;base;Biological Assay;Black race;Cardiac;Cardiac Jelly;Cardiac Myocytes;Cardiovascular system;cell behavior;Cell Communication;Cell membrane;Cells;Chemicals;Clinical;Communication;Coronary;Cryoelectron Microscopy;Cytoplasmic Protein;Data;Defect;Distant;Dyes;Electron Microscopy;Embryo;Endocardium;Etiology;fly;Genetic;Genetic Transcription;Growth;Heart;Image;In Situ Hybridization;in vivo;Knock-out;Label;Left ventricular non-compaction;Ligands;Link;Mammalian Cell;Mammals;Mediating;Membrane;Methods;Microfilaments;Modeling;molecular imaging;Morphogenesis;morphogens;mortality;Motor;Mus;Myocardial;Myocardium;Myosin ATPase;Names;Nanoscopy;Nanotubes;Non-compaction cardiomyopathy;notch protein;novel;novel therapeutic intervention;Organelles;overexpression;Patients;Pattern;Proteins;public health relevance;receptor;Role;Signal Transduction;Signaling Molecule;single molecule;Structure;superresolution microscopy;Surface;System;trafficking;transcriptome sequencing;Transgenic Organisms;Transmission Electron Microscopy;Travel;Vesicle

PROJECT_TITLE: Mechanisms of signaling interaction between endocardium and myocardium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDD-Q (81)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: VA has a strong commitment to transitioning into a Learning Healthcare System characterized by the alignment of science with clinical priorities, the development of rapid and efficient studies, and the leveraging of existing data to deploy and evaluate innovations and best practices. The Center for Evaluation and Implementation Resources (CEIR) will help with this transition by providing administrative support for rapid evaluations based on operational priorities, the coordination of training opportunities in program evaluation and implementation science best practices, and the provision of consultations on project methods, partnerships, and funding. The combination of these services will support the development of core skills among VA employees in evaluation and practice implementation and support the adoption of evidence-informed program management consistent with Evidence Act expectations.

PI_NAMEs: BOWERSOX, NICHOLAS  (contact)

PROJECT_TERMS: Address;Adoption;Area;Authorship;Award;Awareness;Caring;Clinical;clinical care;Clinical Research;Collaborations;Community of Practice;Competence;Consult;Consultations;Data;Databases;design;Development;Employee;Equity;equity, diversity, and inclusion;Evaluation;Evaluation Research;evidence base;expectation;experience;flexibility;Foundations;Funding;Funding Agency;Goals;Growth;Healthcare Systems;Human Resources;implementation evaluation;implementation research;implementation science;implementation strategy;improved;innovation;interest;Knowledge;Lead;Leadership;Learning;learning community;learning strategy;Literature;Medical center;meetings;Mentors;Methods;Monitor;Office of Administrative Management;operation;Operations Research;outreach;Policy Making;Positioning Attribute;primary outcome;Process;Program Evaluation;programs;Qualitative Methods;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Reporting;Research;Research Personnel;residence;Resource Development;resource guides;Resources;response;Route;Science;Service provision;Services;skill acquisition;skills;Slide;Standardization;Statutes and Laws;Structure;success;Time;Training;training opportunity;Work


ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative In this proposal, the Robert Wood Johnson Medical School/Rutgers Biological Mass Spectrometry Facility is requesting funding for a mass spectrometer. This instrument will greatly enhance the ability of scientists on the Piscataway and New Brunswick campuses of Rutgers University to conduct cutting-edge biomedical research and will provide access to cutting-edge technology for many new junior Faculty recruits at Rutgers. Research in areas of medical importance including asthma and respiratory disease, neurological disorders, bacterial and viral infection, endocrine dysfunction, sleep disorders, diabetes, digestive disease, inflammation and cancer, will be facilitated by the requested instrument.

PI_NAMEs: ZHENG, HAIYAN  (contact)

PROJECT_TERMS: 10 year old;Acceleration;Address;applied biomedical research;Asthma;Bacterial Infections;Biological;Biomedical Research;Communities;Data;Diabetes Mellitus;Digestive System Disorders;Disease;Endocrine disruption;Faculty Recruitment;Funding;Inferior;Inflammation;instrument;Label;life span;Liquid Chromatography;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;medical schools;Methods;nano;Nervous System Disorder;New Brunswick;New Jersey;Peptides;Proteome;Proteomics;Request for Applications;Research;Research Personnel;Respiratory Disease;Scientist;skin disorder;Sleep Disorders;System;Technology;United States National Institutes of Health;Universities;Virus Diseases;Wood material

PROJECT_TITLE: A  Bruker timsTOF HT mass spectrometer and nanoflow LC system to upgrade the proteomics facility at Rutgers-New Brunswick and Robert Wood Johnson Medical School

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-T (30)]


NIH_SPENDING_CATS: Aging;Neurodegenerative

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Understanding aging as a systemic process of coordinated changes across organs requires a multifaceted and wholistic research strategy. We will use a comprehensive multi-omics approach of single-cell transcriptomics, metabolomics, proteomics, and bioinformatics to elucidate networks of inter-organ communication that alter metabolism in models of anti-aging, pro-aging, and natural aging in Drosophila.

PI_NAMEs: LI, HONGJIE ;PERRIMON, NORBERT  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Address;Adipose tissue;Adult;Affect;Age;age effect;age related;aged;Aging;aging mechanism;Animals;anti aging;Atlases;Biochemical Pathway;Bioinformatics;biological age;Biological Models;Biology of Aging;Cell Nucleus;Cells;Cellular Stress;Cessation of life;Chronic;Communication;Complex;Data;Data Set;Disease;Distant;Drosophila genus;Drosophila melanogaster;Enzymes;extend lifespan;Fat Body;Fatty acid glycerol esters;feeding;fly;FRAP1 gene;Funding Opportunities;Gene Expression;Genetic Transcription;Health;Health Promotion;healthspan;Human;Individual;insight;Label;life span;Ligands;Link;Longevity;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;Molecular;mTOR inhibition;multiple omics;Muscle;muscle degeneration;muscle stress;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurons;normal aging;novel;Organ;Organism;overexpression;Pathway interactions;Peripheral;Physiological;premature;pro-aging;Process;programs;Protein Secretion;Proteins;Proteomics;receptor;Reporting;Research;response;Role;Science;Severities;Sex Differences;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Sirolimus;Stress;System;Systems Biology;tau Proteins;Tauopathies;Time;Tissue Model;Tissues;transcription factor;transcriptomics;Whole Organism;Work;XBP1 gene

PROJECT_TITLE: Interorgan communication in aging in Drosophila

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-P (J2)]


ORG_STATE: MD

PHR: NARRATIVE The IgE-mediated reactions in allergic diseases are greatly influenced by SYK tyrosine-protein kinase. We have discovered genetic polymorphisms in the SYK gene that are associated with atopy, SYK expression levels, and basophil function. We will determine the genetic regulation of SYK expression and function that affects the phenotypic traits of human basophils in allergies.

PI_NAMEs: GAO, LI  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Adrenergic Receptor;Affect;African ancestry;Agonist;airway inflammation;Alleles;Allergen Immunotherapy;Allergens;Allergic;Allergic Disease;anti-IgE;Asthma;asthmatic;asthmatic patient;atopy;Basophils;Biological;Biological Markers;Blood specimen;carrier status;Cell Physiology;Cell surface;cell type;Cells;Characteristics;Clinical;clinical efficacy;clinical predictors;cytokine;Cytoplasmic Granules;Disease;Disease Progression;Effectiveness;Environment;Environmental Exposure;Enzymes;Epidemic;Epigenetic Process;European ancestry;Event;experimental study;Exposure to;Extrinsic asthma;Future;Gene Expression;Genes;Genetic;Genetic Models;Genetic Polymorphism;genetic signature;Genetic Transcription;Genomic Segment;Glucocorticoids;Goals;Haplotypes;Heterogeneity;Histamine Release;Human;Hypersensitivity;IgE;IgE Receptors;Immune;Individual;inhibitor;Investigation;Lead;Leukotrienes;Light;Link;mast cell;Measurement;Mediating;Mediator;molecular phenotype;Monoclonal Antibodies;Motivation;new therapeutic target;novel strategies;novel therapeutics;omalizumab;Patients;Pharmaceutical Preparations;Phenotype;Play;Population Heterogeneity;predictive marker;Predisposition;Prognosis;promoter;Protein Tyrosine Kinase;Public Health;Quantitative Trait Loci;Reaction;Recombinants;Regulation;Research;response;Role;Severities;Severity of illness;Signal Transduction;Single Nucleotide Polymorphism;single-cell RNA sequencing;Spleen;success;SYK gene;targeted sequencing;Tissues;trait;Transcription Initiation Site;Transcriptional Regulation;transcriptome;transcriptome sequencing;treatment response;Tumor Suppression;Up-Regulation;Variant;Xolair

PROJECT_TITLE: Genetic Control of the SYK Tyrosine-protein Kinase in Allergy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (57)]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Ferroptosis represents a vulnerability in certain cancers with acquired resistance to therapies. Based on my preliminary results, I aim to study the role and mechanism of mitochondrial calcium signaling-mediated acetyl coenzyme A metabolism in the regulation of ferroptotic cell death and antitumor immunity. Understanding the consequence of cancer cell ferroptosis affecting tumor microenvironment will be instrumental for the generation of new therapeutic approaches for cancer treatment.

PI_NAMEs: WEN, HAITAO  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Ablation;Acetyl Coenzyme A;Acetylation;Affect;anti-tumor immune response;Antitumor Response;Apoptosis;Biochemical;Calcium Channel;Calcium Signaling;calcium uniporter;Cancer Biology;cancer cell;Cancer Patient;cancer therapy;cancer type;Cell Death;Coupled;Cyclic GMP;Dependence;DNA;enzyme activity;Enzymes;Exhibits;Gatekeeping;Gene Expression;Generations;Genetic;genetic approach;genetic signature;glutathione peroxidase;Goals;Growth;Hydrogenase;immunogenicity;Immunotherapeutic agent;Immunotherapy;Impairment;improved;In Vitro;in vivo;inhibitor;Inner mitochondrial membrane;insight;Interferon Type I;Interferons;Iron;Knowledge;Lipid Peroxidation;Maintenance;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metabolism;Mitochondria;Modeling;molecular dynamics;Mus;mutant;Myeloid Cells;neoplastic cell;new therapeutic target;novel;novel therapeutic intervention;Organelles;Pathway interactions;Patients;pharmacologic;Pharmacotherapy;Phenotype;Production;programmed cell death protein 1;Proliferating;Protein Acetylation;Proteins;Pyruvate;pyruvate dehydrogenase;refractory cancer;Regimen;Regulation;Rejuvenation;Repression;Research Proposals;Resistance;response;Role;Signal Transduction;single-cell RNA sequencing;synergism;Testing;Therapeutic;therapy resistant;Translating;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells

PROJECT_TITLE: Modulation of ferroptotic cell death by mitochondrial calcium signaling

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW YORK

ORG_DEPT: CHEMISTRY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (PROJECT NARRATIVE) The essential task of synthesizing all the proteins encoded in an organism’s DNA is executed solely by the ribosome and its associated translation machinery (TM). Using a powerful combination of fluorophore-labeled biological components and experimental approaches unique to the applicant’s and their collaborators’ laboratories, this proposal aims to elucidate aspects of the process through which the TM executes and controls protein synthesis that have thus far remained difficult or impossible to investigate. Because the bacterial TM is the target of many clinically relevant small-molecule antibiotics and dysregulation of the human TM plays a causal role in several human diseases, including numerous viral infections and cancers, the results of these studies are expected to identify new targets and strategies for the development of next-generation antibiotics and small- molecule therapeutics for treating viral infections, cancers, and other human diseases.

PI_NAMEs: GONZALEZ, RUBEN L (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Antibiotics;Bacteria;Biochemical;Biological;clinically relevant;Complex;Development;DNA;Ensure;Eukaryota;flexibility;Fluorescence;fluorophore;Gene Expression;Human;human disease;In Vitro;Initiator Codon;Investigation;Label;Laboratories;Life;Link;Location;Malignant Neoplasms;Messenger RNA;Modeling;Molecular Conformation;mutation correction;next generation;Nucleotides;Organism;Peptide Initiation Factors;Play;Process;Production;Protein Biosynthesis;Proteins;public health relevance;Rest;Ribosomal Frameshifting;Ribosomal Proteins;Ribosomes;Role;single molecule;small molecule;small molecule therapeutics;Structure;System;Techniques;Translating;Translation Initiation;Translations;Viral Cancer;Virus Diseases;Yeasts

PROJECT_TITLE: The Structural Dynamics of Translation and Translational Control

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Atherosclerosis-related cardiovascular diseases remain the leading cause of death in the US. We propose to define the protective roles and underlying mechanism of BAF60c-dependent metaboloepigenetic modulations in atherosclerosis. This will provide unique mechanistic insights on the metaboloepigenetic mechanism of atherogenesis and will set the basis to explore new targets for treatment.

PI_NAMEs: ZHAO, GUIZHEN  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Abdominal Aortic Aneurysm;Address;Adoption;anaerobic glycolysis;Antibodies;Aorta;Apolipoprotein E;Apoptosis;Arterial Fatty Streak;atherogenesis;Atherosclerosis;atherosclerosis risk;BCL2 gene;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;Catalytic Domain;Cause of Death;cell behavior;Cell Separation;Cells;Cellular Metabolic Process;Cessation of life;Chimeric Proteins;ChIP-seq;Cholesterol;Chromatin;chromatin modification;Chromatin Remodeling Factor;Chromatin Structure;Chronic;Cleavage Under Targets and Release Using Nuclease;clinical practice;Co-Immunoprecipitations;cofactor;Complex;Coupled;Cues;Data;Disease;Energy Metabolism;environmental change;EP300 gene;Epigenetic Process;epigenetic regulation;epigenome;experimental study;Family;Family member;Fatty Acids;Female;Foam Cells;Functional disorder;Future;gain of function;Gene Expression;Genes;Genetic;Genetic Transcription;Global Change;Glucose;Homeostasis;Human;In Vitro;in vivo;Inflammation;inhibitor;insight;knock-down;Knock-in Mouse;Knock-out;Knockout Mice;Ligands;Link;Lipids;loss of function;Macrophage;male;Mass Spectrum Analysis;member;Metabolic;Metabolism;Modeling;Modification;Molecular;Mus;non-genetic;novel therapeutics;Nuclear Receptors;overexpression;Oxidative Stress;oxidized low density lipoprotein;Phenotype;Plasma;PPAR gamma;preservation;Reaction;Regulation;Research;Residual state;response;Risk Management;Role;selective expression;Serum Response Factor;Sex Differences;sexual dimorphism;side effect;Signal Transduction;single-cell RNA sequencing;SMARCA4 gene;Smooth Muscle Myocytes;Stimulus;Sucrose;Therapeutic;transcription factor;Transcriptional Activation;transcriptome sequencing;transcriptomics;Transgenic Mice;Transgenic Organisms;Vascular Smooth Muscle;western diet

PROJECT_TITLE: Metaboloepigenetics and Atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

ORG_STATE: MA

PHR: Periodontal diseases are common chronic inflammatory disease, afflicting up to 50% of the adult population in the United States and associated with systemic diseases, such as diabetes and cardiovascular disease. The proliferation of anaerobic bacteria below the gumline is central to disease progression, with Porphyromonas gingivalis being implicated as one of the primary endogenous pathogens. We are studying how this bacterium controls the production of its surface polysaccharides and membrane lipids, which are key determinants of its virulence.

PI_NAMEs: DAVEY, MARY ELLEN (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Adult;Anaerobic Bacteria;Anti-sense RNA;Antigens;Bacteria;Biochemical;capsule;Cardiovascular Diseases;Cell surface;cell type;Cells;Cellular Metabolic Process;ChIP-seq;Chromosomes;chronic inflammatory disease;Collection;Data;Development;Diabetes Mellitus;Disease Progression;Elements;EMSA;Environment;Etiology;Family member;Gene Expression;Genes;Genetic;genetic regulatory protein;Genomics;Goals;Growth;Heme;heme a;Homeostasis;Immune Evasion;immunoregulation;insight;Knowledge;Ligands;Link;Lipopolysaccharides;Membrane Lipids;Methods;Microbe;Microbial Biofilms;Modeling;Molecular;Molecular Conformation;mutant;novel;novel therapeutic intervention;Nutritional;Operon;Oral;oral pathogen;Outcome Study;overexpression;pathogen;Pathogenesis;Pathogenicity;Periodontal Diseases;Play;Polysaccharides;Population;Porphyromonas gingivalis;Production;programs;Proliferating;Proteins;Publishing;Regulation;Regulatory Pathway;Research;response;Role;sensor;Signal Pathway;Signal Transduction;Sphingolipids;Structure;Surface;Surface Plasmon Resonance;Surface Properties;System;Systemic disease;Techniques;Testing;Therapeutic;United States;Virulence;Virulent

PROJECT_TITLE: Regulatory Mechanisms Controlling P. gingivalis Surface Structures

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: BOCA RATON

ORG_NAME: AVENTUSOFT, LLC

ORG_STATE: FL

PHR: PROJECT NARRATIVE Overall this project provides direct relevance to public health by facilitating new insights through the development of a novel mobile framework to be used in current clinical practice for non-invasive direct assessment of the left ventricular end diastolic pressure. The novel biologically-inspired device will significantly impact the current known methods for detection, monitoring, prevention and treatment of heart failure, and support evidence-based clinical practice. The project will help reduce health disparities in the area of heart disease, assist in providing preventive cardiac care, assist in improving access to care, assist in early diagnosis of the risk of heart diseases and it will significantly impact the current known methods, technologies, treatments, and address critical barriers to progress in the field.

PI_NAMEs: KALE, KAUSTUBH  (contact)

PROGRAM_OFFICER_NAME: LUO, JAMES

PROJECT_TERMS: Accounting;Acute;Address;Affect;African American population;Age;Algorithms;Android;Area;Biological;Biosensor;Blood Pressure;Cardiac;Cardiac Catheterization Procedures;Cardiac health;Cardiopulmonary;Cardiovascular Diseases;Caring;Catheters;Cause of Death;Cellular Phone;Cessation of life;checkup examination;Chest wall structure;Chronic;Clinic;Clinical;clinical diagnostics;clinical practice;Collaborations;commercialization;Communities;cost;cost effective;Data;Detection;detection method;Development;Devices;Diagnosis;Diagnostic;diagnostic development;Diagnostic Equipment;Diastolic blood pressure;Disease Management;Early Diagnosis;Echocardiography;Engineering;Evaluation;evidence base;Female;Florida;Goals;handheld mobile device;Health;health care quality;health disparity populations;Health Fairs;Health Personnel;Health Professional;Health Services Accessibility;Health Technology;Heart;Heart Auscultation;heart disease risk;Heart Diseases;Heart failure;Height;Home;Improve Access;improved;innovation;insight;Institution;Institutional Review Boards;Joints;Left;male;Measurement;Measures;Medical;Medical center;meetings;men;Methods;mHealth;Minor;minority disparity;Monitor;Morphologic artifacts;Motion;Noise;Not Hispanic or Latino;novel;Pathologic;Pathway interactions;Patient Representative;Patients;Performance;Phase;Physicians;Physiologic Monitoring;Pilot Projects;portability;Predictive Value;pressure;Prevention;Preventive;Primary Care;provider communication;Public Health;recruit;Reduce health disparities;Resource-limited setting;Running;Science;screening;sensor;Signal Transduction;Site;skills;Small Business Innovation Research Grant;smartphone application;Specificity;System;Technology;telehealth;Telemedicine;Testing;time interval;Training;Triage;Underserved Population;Validation;Variant;Ventricular;Visit;Weight;Woman;women patients;Work

PROJECT_TITLE: A mobile health framework for left ventricular end diastolic pressure diagnostics and monitoring.


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Bacteria can be engineered as live therapeutics for broad biomedical applications. The proposed research will enable the creation of safe and effective therapeutic bacteria.

PI_NAMEs: TAN, CHEEMENG  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Address;Bacteria;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;commensal bacteria;Communities;Devices;Disease;Dose;Drug Delivery Systems;drug synthesis;Ecosystem;Engineering;Ensure;Future;Gene Expression;Genes;Growth;Human body;Hybrids;information processing;interest;Measures;Metabolism;microdevice;Molecular;mutant;Mutation;Patients;preservation;prevent;Proliferating;Protein Biosynthesis;Proteins;Research;Safety;Site;Stimulus;Synthetic Genes;Therapeutic;therapeutically effective;tool;Work

PROJECT_TITLE: Dissecting the non-growing-but-active state of a hybrid bacteria-material microdevice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRATIVE Radiation therapy of cancers fails when surviving cells repopulate and regenerate a tumor. Our goal is to identify and study genes and proteins needed for such regeneration. Inhibition of these genes and proteins, with drugs for example, could prevent regeneration and thereby increase the potency of radiation therapy.

PI_NAMEs: SU, TIN TIN  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;Apoptotic;Biogenesis;Biological Assay;cancer cell;Cancer Model;Cancer Patient;cancer radiation therapy;cancer survival;cancer therapy;Caspase;Cell Death;cell killing;cell regeneration;Cell Survival;cell type;Cells;Chemicals;Columnar Epithelium;Dedications;Development;DNA Repair;Drosophila genus;Drosophila melanogaster;Epithelial Cells;Funding;Future;gene function;Genes;Genetic;Goals;Growth;Human;imaginal disc;improved;in vivo;Induction of Apoptosis;innovation;Ionizing radiation;Lead;Learning;Malignant Neoplasms;Modeling;Molecular;Molecular Analysis;Natural regeneration;Organ;Organism;Pharmaceutical Preparations;prevent;Process;programs;Property;Proteins;Proteome;Radiation induced damage;Radiation Induced DNA Damage;Radiation therapy;Refractory;Research;Ribosomes;stem cells;stemness;Testing;tissue regeneration;tool;transcriptome;Translating;Translations;Treatment Failure;Treatment outcome;tumor;Vertebrates;Wing;Work

PROJECT_TITLE: Cellular plasticity and regeneration afterradiation damage in Drosophila

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]