NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: apple valley

ORG_NAME: METSELEX, INC.

ORG_STATE: MN

PHR: PROJECT NARRATIVE Metselex has succeeded in producing safe and effective ursodeoxycholic acid (UDCA) derivatives for treating neurodegenerative disease. However, the supply-chain of UDCA is limited and is driven by either (i) the inhumane/illegal harvesting of bile acids from bears, or (ii) semi-synthesis from starting materials isolated from animal gall bladders. The research proposed here will give Metselex an economical and sustainable source for UDCA via a synthetic metabolic pathway in yeast. Metselex is developing new first-line drugs to combat neurodegenerative diseases. Acute and chronic neurodegenerative diseases are the leading causes of death and disability in the USA and world. The economic burden on society that results from treatment costs and lost productivity is substantial. Current estimates of the cost of care are almost $1T per year for chronic neurodegenerative patients in the US, including $600B just for Alzheimer’s Disease, growing to $2T by 2050 The research proposed here will enable the large-scale production of new UDCA-derived therapeutics for these diseases that will result in better patient outcomes. Success of Metselex’s drug development pipeline depends on an economical source of UDCA, which will be produced on this effort. Lastly, the tools and techniques developed to overcome technical hurdles in this project will be broadly useful in the design and construction of other synthetic metabolic pathways to support a bio- based chemical production industry.

PI_NAMEs: GEORG, GUNDA I.;LOW, WALTER C;SMANSKI, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Abate;Acute;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;amyloid precursor protein processing;Anabolism;analog;analytical method;Animal Disease Models;Animal Model;Animals;Apoptosis Inhibitor;Apoptotic;APP-PS1;Artemia;Bacteria;Bile Acids;Biological Assay;Biomanufacturing;Businesses;care costs;Cause of Death;Cell Death;Cell model;Cells;Cellular Membrane;Chemicals;Cholesterol;Cholic Acids;Chronic;Cognitive deficits;combat;Complex;Contracts;cost estimate;Dendrites;Dendritic Spines;design;design and construction;Development;disability;Disease;DNA;DNA biosynthesis;Dose;drug development;Drug Kinetics;Economic Burden;endoplasmic reticulum stress;Engineering;Enzymes;Ergosterol;experience;Fermentation;Foundations;frontal lobe;Gallbladder;gene product;Genes;Genetic;Goals;Grant;gut microbiome;Harvest;Hippocampus;Human;improved;In Vitro;in vitro Assay;in vivo;in vivo evaluation;Industrialization;Industry;large scale production;Lead;Learning;Livestock;manufacture;manufacturing organization;manufacturing technology;Marketing;Memory impairment;Metabolic;Metabolic Pathway;microbial;microbial host;Minnesota;Mitochondria;mouse model;Nerve Degeneration;neural;Neurodegenerative Disorders;neuroprotection;Neuroprotective Agents;new technology;novel;novel therapeutics;Organism;Outcome;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phase;Phase I Clinical Trials;Phosphorylation;potency testing;Preparation;prevent;Process;Production;Productivity;Property;Proteins;Qualifying;Reactive Oxygen Species;Recombinants;reconstitution;Research;response;Role;scale up;screening;Small Business Technology Transfer Research;Societies;Solid;Source;Specificity;success;supply chain;Synapses;System;tau Proteins;tauroursodeoxycholic acid;Techniques;Technology;Technology Transfer;Testing;Therapeutic;tool;Treatment Cost;unethical;Universities;Ursodeoxycholic Acid;Vertebral column;Work;Yeasts;Zebrafish

PROJECT_TITLE: Microbial Synthesis of Therapeutic Bile Acids for Alzheimer's Disease


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: FORT COLLINS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: The Infectious Disease Research and Response Training Program will support predoctoral students engaged in research to address the prevention of infectious disease emergence and ongoing pandemics that threaten human health globally. Trainees will benefit from the vast expertise of experienced mentors, state-of-the-art facilities, and substantial institutional programmatic resources and extra-mural funding. Together, activities to encourage synergism in training, and unique experiential opportunities will provide diverse cohorts of predoctoral trainees with the necessary skills to confront infectious disease threats to human health as they embark upon academic or non-academic research careers.

PI_NAMEs: DEAN, GREGG A (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Infectious Diseases Research;response;Training Programs

PROJECT_TITLE: CSU Infectious Disease Research and Response Training Program

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: APT imaging is capable of detecting abnormal protein accumulation associated with AD, including amyloid beta and tau protein, which will enable the early detection of AD pathology. If our aims are achieved, this project will provide the critical sensitivity and specificity data for APT-MRI to identify MCI and distinguish AD dementia and dementia with Lewy bodies. We expect to ultimately provide several entirely new, endogenous protein-based MRI biomarkers, with which to visualize AD non-invasively with routine clinical MRI scanners.

PI_NAMEs: ZHOU, JINYUAN  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta accumulation;Abeta clearance;Acceleration;Acidosis;Acute;Address;age related;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amides;Amyloid;Amyloid beta-Protein;Amyloid deposition;Autopsy;Biological Markers;biomarker validation;Brain;Brain Diseases;Brain Neoplasms;Brain region;Cell Density;Cerebral cortex;Cerebral Ischemia;Characteristics;Classification;Clinical;clinical decision-making;Clinical Research;Cognitive;Data;Dementia;Dementia with Lewy Bodies;Deposition;Development;Diagnosis;Disease;Early Diagnosis;Elderly;Event;Exposure to;extracellular;FDA approved;Fingerprint;follow-up;Foundations;frontal lobe;Goals;histopathological examination;Image;imaging study;Imaging technology;in vivo;Individual;innovation;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant neoplasm of brain;Measures;medial temporal lobe;Methodology;Methods;mild cognitive impairment;monomer;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;novel;Pathogenesis;Patients;Pattern;Peptides;Positron-Emission Tomography;pre-clinical;preclinical study;Production;Proteins;Protocols documentation;Protons;radio frequency;Research;Research Personnel;Sample Size;Senile Plaques;Sensitivity and Specificity;Signal Transduction;Stroke;Surrogate Markers;synaptic function;System;targeted biomarker;tau Proteins;Techniques;Technology;Temporal Lobe;Time;Tissues;Translating;transmission process;validation studies;Visualization

PROJECT_TITLE: Developing Protein-based MRI Biomarkers for Alzheimer's Disease

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because determining the relationship between microglial activation, tau pathology, and neurodegeneration in Alzheimer's disease is expected to inform future strategies to predict and prevent progression to dementia. Thus, the proposed research is relevant to the NIA's mission that pertains to developing fundamental knowledge that will reduce the burden of Alzheimer's disease on society.

PI_NAMEs: SMALL, SCOTT A (contact)

PROJECT_TERMS: Affect;Age of Onset;Alzheimer's Disease;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Autopsy;Binding;Binding Proteins;Biological Markers;Brain region;cerebral atrophy;Clinical;clinical subtypes;cohort;Data;Dementia;density;dimension reduction;Disease;Disease Progression;disorder subtype;follow-up;Future;glial activation;Goals;gray matter;Heterogeneity;hyperphosphorylated tau;imaging biomarker;imaging study;immune modulating agents;Impaired cognition;improved;In Vitro;Inflammation;Inflammatory;inflammatory marker;innovation;Knowledge;Laboratories;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measures;Mediating;Microglia;Mission;Monitor;Nerve Degeneration;Neuroanatomy;Neurofibrillary Tangles;neuroinflammation;neuron loss;novel;novel therapeutics;Outcome;participant enrollment;Pathogenesis;Pathologic;Pathology;Patients;Pattern;Positron-Emission Tomography;prevent;Primary Progressive Aphasia;Procedures;Proteins;Public Health;radioligand;recruit;Research;response;Role;serial imaging;Signal Transduction;Societies;spatial relationship;tau aggregation;tau Proteins;Tauopathies;Testing;Therapeutic;Thick;Time;Tracer;Transgenic Animals;Variant;white matter

PROJECT_TITLE: Longitudinal imaging of microglial activation in different clinical variants of Alzheimer's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Parenting interventions that strengthen parent-child relationships, teach positive discipline techniques, decrease harsh parenting, and improve child behaviors have been identified as a key child maltreatment prevention strategy; however, challenges in effectively implementing parenting interventions and engaging high-risk families has greatly limited their impact. Child Adult Relationship Enhancement in Primary Care (PriCARE/Cariño), a brief group positive parenting intervention delivered in the pediatric primary care setting, has demonstrated success in engaging high risk families, promoting positive parenting techniques, decreasing harsh parenting, reducing parent stress, and improving child behavioral problems and has the potential to decrease child maltreatment. Therefore, our objective is to conduct a multisite RCT of PriCARE/Cariño to achieve 3 aims: (1) evaluate the effect of PriCARE/Cariño on reducing child maltreatment; (2) examine the mediating effects of parenting, parent stress, and child behavior on the relationship between PriCARE/Cariño and child maltreatment; and (3) identify and understand the relationship between PriCARE/Cariño implementation determinants and key implementation outcomes.

PI_NAMEs: SCHILLING, SAMANTHA S (contact);WOOD, JOANNE NICOLE

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: 6 year old;abuse neglect;Address;Adult;Age;Child;Child Abuse and Neglect;Child Behavior;Child Development;child protective service;Child Rearing;Childhood;Chronic Disease;Clinic;Collaborations;Complex;Computerized Medical Record;Consent;Data Collection;design;Development;disability;Discipline;dissemination strategy;Distal;Dose;Ecology;Economic Burden;Economics;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness trial;Eligibility Determination;Emotional;Enrollment;ethnic diversity;Evaluation;Family;Foundations;Funding;Future;Goals;Health;Heart;High Prevalence;high risk;Hispanic;implementation barriers;implementation determinants;implementation evaluation;implementation outcomes;implementation strategy;improved;Individual;Insurance;intergenerational;Knowledge;Longitudinal Studies;Low income;lower income families;maltreated children;Mediating;Medicaid;Mental Depression;Mental Health;Methods;Minority;Monitor;National Institute of Child Health and Human Development;neglect;North Carolina;Not Hispanic or Latino;Outcome;Parent-Child Relations;parenting intervention;Parents;Participant;Pediatric Hospitals;pediatric trauma;Penetration;permissiveness;Philadelphia;physical abuse;Poverty;prevent;Prevention;Prevention strategy;Prevention trial;preventive intervention;Primary Care;primary care clinic;primary care setting;Problem behavior;Process;Productivity;programs;Provider;Public Health;Punishment;racial diversity;Randomized;Randomized, Controlled Trials;Recording of previous events;Reporting;Research;Risk;scale up;Science;Site;skills;social;social stigma;societal costs;Spanish/English;Stress;success;Techniques;Testing;therapy design;transmission process;treatment as usual;Uninsured;Universities;uptake;Work

PROJECT_TITLE: Child-Adult Relationship Enhancement in Primary Care: Effectiveness Trial of a Primary Care Based Parenting Intervention to Prevent Child Maltreatment

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

ORG_STATE: CA

PHR: Women Veterans are a rapidly growing segment of new Veterans Health Administration (VA) patients. Many get at least some of their care in the community, paid for by VA, to ensure that they have access to the services they need. For the past four years, our team has been studying why a sizable proportion of women do not continue to use VA on a long-term basis, and we have found clues that this “Community Care” may have interesting influences on women's VA care. This study will examine those influences more closely, using both existing databases and qualitative interviews to understand how patient experiences of VA care and Community Care influence women and men Veterans' decisions about whether to stay in or leave VA. Our study is meant to inform systems improvements that will benefit all women and men in VA. Sustained engagement of Veterans in VA care could promote preventive care to avert or reduce late-life diseases and their adverse effects on healthcare costs and quality of life.

PI_NAMEs: FRAYNE, SUSAN  (contact);HAMILTON, ALISON B.

PROJECT_TERMS: Accounting;ACE2;Address;Adverse effects;Area;Behavioral Model;care coordination;care fragmentation;care providers;Caring;Characteristics;Clinic;cohort;Communities;Communities That Care;Community Healthcare;community planning;Data Sources;Databases;design;Development;Disease;Elements;expectation;experience;Future;Gender;Goals;Health;Health Care Costs;Health Services Accessibility;Healthcare;Home;implementation barriers;improved;Intervention;Interview;late life;Lead;Learning;men;Mental Health;Methods;Modeling;Organizational Change;Outsourcing;patient subsets;Patient-Centered Care;Patients;Phase;Policies;Positioning Attribute;prevent;Preventive care;primary care patient;primary care provider;Process;programs;Provider;Quality of life;Recommendation;Reporting;Research;Research Design;Resources;Risk;Services;Site;Statutes and Laws;Structure;Subgroup;System;Telephone Interviews;theories;Time;Time trend;Veterans;Veterans Health Administration;Woman;women of color;women patients;Women's Health;Work;young woman

PROJECT_TITLE: Attrition of Women Veterans New to VHA in the Community Care Era

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Surgical site infection (SSI) rates following appendectomy for uncomplicated, non-perforated appendicitis remain unacceptably high, with a recent review reporting pelvic abscess rates of 9.4%. Despite the use of therapeutic antibiotics initiated in the ED, the appendectomy often does not occur for 4-18 hours, meaning that, at the time of surgery, the amount of therapeutic antibiotics on board is unknown and the role of prophylactic antibiotics is unclear. This study will develop personalized antibiotic dosing algorithms based on time to surgical appendectomy with the goals of optimizing tissue antibiotic exposure at the surgical site, avoiding use of unnecessary antibiotics (selective antibiotic resistance pressure), and reducing toxicity.

PI_NAMEs: PAI, MANJUNATH P (contact);WANG, STEWART C

PROGRAM_OFFICER_NAME: LIN, LEYI

PROJECT_TITLE: Precision coordination of therapeutic and prophylactic antibiotics to reduce infection, toxicity, and emergence of resistance following acute abdominal surgery

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: MONTGOMERY

ORG_NAME: ALABAMA STATE DEPT OF AGRIC & INDUSTRIES

ORG_STATE: AL

PHR: PROJECT NARRATVE The Alabama Department of Agriculture and Industries (ADAI) will continue to maintain a produce safety regulatory program that addresses the growing, packing, harvesting, and handling of produce grown on farms. ADAI will continue to encourage the safe production of covered fruits and vegetables and promote understanding and compliance with the FDA’s Produce Safety Rule through education, outreach, technical assistance, and training. By continuing these practices, ADAI is confident there will be less foodborne illness outbreaks nationwide traced back to raw produce grown in the state of Alabama as well as for Alabama residents consuming locally grown produce that is safe to eat.

PI_NAMEs: TIPTON, ANDY  (contact)

PROGRAM_OFFICER_NAME: VARGO, ADRIANNA

PROJECT_TITLE: Path C ADAI will continue to maintain a produce safety regulatory program to encourage the safe production of covered produce while using Path C as a guide to complete all objectives specified.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE The current proposal will assess tau PET and its association with early Braak NFT stages (I-IV) and cognitive test abnormalities and we will leverage our database of 1779 participants who have had tau PET over the past 6 years to provide a well characterized cohort for this study at substantial cost savings. Our objectives are to use innovative tau PET imaging and analysis methods to predict early Braak NFT stages and cognitive test findings in a large sample of early Braak stage subjects. This work will provide a rigorous clinicopathologic assessment of the capability of tau PET to detect the presence of early NFT pathology and will provide data that could improve subject selection for AD treatment trials.

PI_NAMEs: LOWE, VAL JOHN (contact);MURRAY, MELISSA ERIN

PROJECT_TERMS: abeta accumulation;Aging;Algorithms;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Amyloid;amyloid pathology;Autopsy;Autoradiography;Biological;Clinic;Clinical;Cognitive;cognitive testing;cohort;Cohort Studies;Cost Savings;Data;Data Correlations;Databases;Dementia;Deposition;detection method;Early Diagnosis;Goals;high risk;hyperphosphorylated tau;Immunohistochemistry;improved;in vivo;indexing;Individual;innovation;insight;interest;Knowledge;Magnetic Resonance Imaging;Measurement;Methodology;Methods;Neurodegenerative Disorders;Neurofibrillary Tangles;neuropathology;novel;Participant;Pathologic;Pathology;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Positron-Emission Tomography;Prevention trial;radiotracer;Research;Research Personnel;Sampling;Scanning;Selection for Treatments;Senile Plaques;Severities;Severity of illness;Signal Transduction;Subjects Selections;Symptoms;tau Proteins;Tauopathies;Testing;therapeutic biomarker;Tracer;treatment trial;uptake;Validation;Work

PROJECT_TITLE: Tau PET/CT for Early Detection of Alzheimer’s Disease Pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-W(02)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Pediatric

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: PROJECT NARRATIVE Genetic research into attention deficit hyperactivity disorder (ADHD) lags in terms of: (1) sample size, (2) ancestral diversity, and (3) consideration of phenotypic heterogeneity. The Akili project will address all three of these critical gaps, phenotypically and genetically characterizing 4,000 children with ADHD and 2,000 age- and ancestry-matched controls in Kenya and South Africa. All data and materials from Akili will be made publicly available through the NIMH, creating a research resource of international value.

PI_NAMEs: DONALD, KIRSTY  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Address;Africa;African;Age;Architecture;Area;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Award;Behavioral;Biological;Caring;case control;Child;Clinical;clinically relevant;Cognitive;cohort;Collection;Data;Data Collection;design;Development;Diagnosis;diagnostic criteria;Disease;DNA;doctoral student;Education;Enrollment;Ensure;Equity;European ancestry;executive function;exome;exome sequencing;Fruit;Funding;gene discovery;Generalized Anxiety Disorder;Genes;Genetic;genetic architecture;Genetic Research;Genetic Risk;Genetic study;genome wide association study;genome-wide;Genomics;Genotype;Goals;Health;Heterogeneity;Hyperactivity;improved;Impulsivity;insight;Intellectual functioning disability;International;Interview;Kenya;Lead;Leadership;Link;Maps;Medical;Medical History;member;Mind;Mood Disorders;National Institute of Mental Health;Neurodevelopmental Disorder;neuropsychiatric disorder;neuropsychiatry;non-verbal;Occupational;Outcome;Parents;Participant;Phenotype;phenotypic data;polygenic risk score;Population;psychiatric genomics;rare variant;Raven;recruit;Research;Resources;risk sharing;risk variant;Saliva;Sample Size;Sampling;Schedule;School-Age Population;Scientist;Severities;sex;Site;skills;social;South Africa;South African;Speed;Students;success;Sustainable Development;tool;Training;trait;United States;Variant;Work

PROJECT_TITLE: 3/3 Akili: Phenotypic and genetic characterization of ADHD in Kenya and South Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-Z(60)C]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Page 222

PI_NAMEs: REILLY, MUREDACH P (contact)

PROGRAM_OFFICER_NAME: ATIENZA, AUDIE A

PROJECT_TERMS: Acceleration;Address;career;Clinical and Translational Science Awards;Clinical Research;Clinical Sciences;Clinical Trials Design;Collaborations;college;Communities;COVID-19 pandemic;Dental;dissemination science;Education;Electronic Health Record;Environment;Evaluation;Evolution;experience;Faculty;flexibility;Foundations;Friends;Goals;Health;Health Benefit;Health system;Healthcare;Hospitals;implementation science;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;Laboratories;Lead;Leadership;Learning;Medical center;Medicine;meetings;member;Methods;Mission;Modeling;New York;New York City;novel;novel therapeutics;operation;opioid epidemic;Patients;Personal Satisfaction;Phase;Physicians;precision medicine;Presbyterian Church;Problem Solving;Process;Program Development;programs;Public Health;Public Health Schools;Recording of previous events;Research;Research Methodology;Research Personnel;Resources;School Nursing;Schools;Science;Speed;Strategic Planning;Strategic vision;success;Surgeon;synergism;Time;Training;translational pipeline;Translational Research;Universities;user-friendly;Vision;Workforce Development


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: TEMPE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Narrative The perivascular niche within the GBM tumor microenvironment (TME) protects glioma stem cells (GSCs) from genotoxic damage, promotes their stemness, and invasion. Despite its importance, how the cell-cell interactions between various cellular components of the perivascular niche modulate GSC behavior (proliferation vs. quiescence and invasion vs. homing) and therapy resistance is poorly understood. In this study, we propose to develop ex vivo microengineered and bioinspired model of the GBM perivascular niche to mechanistically examine, at single cell resolution, the role of cellular components within the niche on GSC biology and response to treatment.

PI_NAMEs: NIKKHAH, MEHDI  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 3-Dimensional;Address;Affect;Architecture;Astrocytes;Behavior;Bioinformatics;Biological;Biological Assay;Biological Models;Biology;Biomedical Engineering;Biomimetics;Blood capillaries;Blood Vessels;cell behavior;Cell Communication;Cell Maintenance;cell type;Cells;chemotherapeutic agent;Complex;conventional therapy;Cultured Cells;CXCR;CXCR4 gene;Data;Development;Disease;Disease Progression;Dose;Endothelial Cells;endothelial stem cell;Engineering;Excision;Exposure to;Genetic;Genomics;genotoxicity;Glioblastoma;Glioma;Goals;Homing;Human;Hypoxia;Immune;In Vitro;in vivo;in vivo Model;Individual;insight;interdisciplinary approach;Interruption;Invaded;irradiation;Knowledge;Ligands;Mediating;Methods;Microfluidic Microchips;Microfluidics;Microglia;Modeling;Molecular;mouse model;multidisciplinary;neoplastic cell;novel;Oncology;Operative Surgical Procedures;Organoids;Pathway interactions;Patients;Pericytes;pharmacologic;Physiological;Positioning Attribute;Prediction of Response to Therapy;Proliferating;Property;Radiation;radiation resistance;Radiation therapy;receptor;Recurrent tumor;Research Design;Resistance;Resolution;response;Role;Sampling;self-renewal;Shelter facility;single cell genomics;single-cell RNA sequencing;Site;Slice;small hairpin RNA;Specificity;stem;stem cell biology;stem cell proliferation;stem cells;stemness;Stromal Cell-Derived Factor 1;targeted treatment;therapy resistant;three dimensional cell culture;three-dimensional modeling;Time;Tissue Engineering;Tissues;transcriptome sequencing;transcriptomics;treatment response;tumor;tumor microenvironment;Tumor Tissue;Tumorigenicity;Validation

PROJECT_TITLE: Elucidating the Role of Perivascular Niche in Glioblastoma Invasion and Therapeutic Resistance at Single Cell Resolution using Biomimetic Tumor Microenvironment Models

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Spontaneous intracerebral hemorrhage (ICH) results when vessels affected by progressive Cerebral Small Vessel Disease (CSVD) rupture inside the brain. Because CSVD is progressive, ICH survivors, particularly Black and Hispanic survivors, are at high risk for Vascular Cognitive Impairment / Dementia (VCID) and recurrent stroke. Control of hypertension is powerful way to prevent VCID and recurrent stroke, but fewer than half of ICH survivors ever have their hypertension controlled. We will perform a comprehensive assessment of social determinants of health to make crucial discoveries that can be used to help people with ICH control their hypertension, prevent VCID and stroke, and close a substantial health care disparity. Success will add years of quality of life for >50,000 Americans who recover from ICH every year.

PI_NAMEs: ROSAND, JONATHAN  (contact);TOWFIGHI, AMYTIS

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: Acceleration;Acute;Affect;American;Asian population;Biological Factors;Black Populations;Black race;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure intervention;blood pressure reduction;Brain;Brain hemorrhage;burden of illness;Caring;Cerebral hemisphere hemorrhage;Cerebral small vessel disease;Clinical;Clinical Trials;cohort;community based participatory research;Data;Dementia;design;Disparity;Economically Deprived Population;Enrollment;ethnic disparity;Ethnic Origin;Evidence based program;experience;Failure;functional decline;Funding;Future;Genetic;Goals;health care availability;health care disparity;health disparity;health inequalities;health literacy;Health Services Accessibility;healthspan;high risk;Hispanic;Hispanic Populations;Hypertension;hypertension control;Image;Impaired cognition;improved;improved outcome;Individual;Inequity;Intervention;Knowledge;Life;longitudinal course;Mediating;Medical;Minority Groups;Morbidity - disease rate;mortality;multi-racial;novel strategies;Outcome;patient engagement;Patients;personalized intervention;Persons;post stroke;prevent;Prevention;programs;Quality of life;Race;racial disparity;randomized trial;recruit;Recurrence;Reporting;Research;Risk;risk prediction;Role;Rupture;Shapes;social;social health determinants;Social Network;Social support;socioeconomic disadvantage;Standardization;Stroke;stroke survivor;Subgroup;success;Survivors;System;Testing;Time;Vascular Cognitive Impairment;vascular cognitive impairment and dementia

PROJECT_TITLE: Race / Ethncicity, Hypertension and Prevention of VCID and Stroke after Intracerebral Hemmorrhage

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHICAGO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: In this work we use non-equilibrium statistical mechanics frameworks, artificial intelligence tools and computer simulations to predict and model how various biological systems and processes, such as those responsible for cell shape and locomotion, and cell signaling perform their jobs robustly.

PI_NAMEs: VAIKUNTANATHAN, SURIYANARAYANAN  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Artificial Intelligence;Biological;Biological Process;biological systems;Biophysical Process;Biophysics;Cell Communication;Cell division;Cell membrane;cell motility;Cell Shape;Cells;Complex;computer framework;Computer Simulation;Cytoskeletal Modeling;Data;Development;Disease;driving force;Ensure;Equilibrium;Event;Generations;Goals;Health;Human;immune system function;Length;Lysosomes;Machine Learning;Membrane Fusion;Microscopic;Modeling;Molecular;Morphogenesis;Morphology;Occupations;Pattern;Play;Process;response;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Statistical Mechanics;System;Techniques;Time;Tissues;tool;Work

PROJECT_TITLE: Elucidating biophysical mechanisms for force sensing and control using non-equilibrium statistical mechanics and AI


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: DAVIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE: Atrial fibrillation (AF), the most common cardiac arrhythmia, affects about ~1-2% of the general population. A complex, progressive disease, it sharply increases the risk of stroke and often coexists with and worsens other severe cardiac diseases, particularly heart failure. This project aims to achieve a better understanding of the mechanisms underlying AF via new research tools, including state-of-the-art computer models, which will ultimately lead to improved treatments and outcomes for patients.

PI_NAMEs: GRANDI, ELEONORA  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Affect;Architecture;Arrhythmia;Atrial Fibrillation;Atrial Function;base;Behavior;Blood Pressure;Cardiac;Cardiomyopathies;Cell Physiology;Cell surface;Cells;Centers for Disease Control and Prevention (U.S.);Chronic;Complex;Computer Models;Computer software;Coupled;Couples;Coupling;Data;Databases;design;Development;Disease;Disease Progression;Electrophysiology (science);embolic stroke;Event;Exhibits;experimental analysis;experimental study;Failure;Fibrosis;Fracture;Functional disorder;General Population;Goals;Health;Heart Atrium;Heart Diseases;Heart failure;hemodynamics;Heterogeneity;Human;human tissue;improved;In Situ;Infrastructure;insight;Lead;Link;Literature;Maintenance;Maps;Measures;Membrane;Modeling;Molecular;mortality;multi-scale modeling;Muscle Cells;Myocardial Contraction;Myocardium;Nature;novel;novel therapeutic intervention;Oryctolagus cuniculus;Outcome;Pathologic;Pathology;Patient-Focused Outcomes;Patients;Persons;Pharmacotherapy;Population;Predisposition;pressure;Process;Progressive Disease;Quality of life;Research;Role;simulation;Site;stroke risk;Structure;synergism;Systolic heart failure;targeted treatment;Testing;Therapeutic;Tissues;tool;treatment and outcome;Variant;Ventricular Dysfunction

PROJECT_TITLE: Quantifying the role of myocyte ultrastructure in atrial health and disease

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative This project investigates the mechanisms of tumor cell-extracellular matrix (ECM) interactions during dormancy. Outcomes will reveal how cancer cells remodel the ECM to create a COL III rich dormancy-supportive niche and the role of COLIII/DDR1 in this process. Findings will be applied towards finding novel anti-metastatic targets.

PI_NAMEs: BRAVO-CORDERO, JOSE JAVIER  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Adult;Aftercare;Binding;Biology;Blood Vessels;Bone Marrow;Brain;cancer cell;Cancer Patient;Cause of Death;cell assembly;Cell Communication;Cell Cycle;Cell Physiology;Cell Proliferation;Cells;Cessation of life;Collaborations;Collagen;Collagen Fibril;Collagen Receptors;Collagen Type III;Data;DDR1 gene;Deposition;Disease;Disseminated Malignant Neoplasm;Down-Regulation;Extracellular Matrix;Fibrillar Collagen;Fibronectins;Gene Expression Profiling;Genetic Transcription;Goals;Growth;high resolution imaging;imaging approach;Imaging Device;Immune;improved;in vivo;innovation;Interruption;Intervention;Invaded;Liver;Lung;Malignant Neoplasms;Measures;Mediating;Messenger RNA;Methodology;Methods;migration;Modeling;Molecular;multiphoton imaging;Neoplasm Metastasis;neoplastic cell;Non-Fibrillar Collagens;novel;Organ;Outcome;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;Phenotype;Phosphorylation;prevent;Primary Neoplasm;Process;protein expression;Proteins;Proteome;Proteomics;receptor binding;Reporter;Research Design;Role;second harmonic generation imaging;Signal Transduction;Site;STAT1 gene;stem cells;Stromal Cells;Survival Rate;Tenascin;Testing;Time;Transcript;transcriptomics;tumor;tumor growth;Tumor-Derived;Work

PROJECT_TITLE: Defining the role of type III collagen and the collagen-binding receptor DDR1 in metastatic dormancy

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: Newark

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Cigar use is a significant public health concern, particularly among vulnerable populations. The proposed longitudinal and policy impact analyses will examine the impact of cigar pack quantity on tobacco use behaviors. This research will directly address the FDA Center for Tobacco Products Scientific Domains of behavior and impact analysis, and findings may inform future FDA rulemaking on cigar pack quantity.

PI_NAMEs: JENSEN, JESSICA KING (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adolescent Risk Behavior;Adult;Affect;Age;Area;authority;Behavior;Black Populations;career development;Characteristics;Cigar;Cigar Smoking;Cigarette;cigarette smoking;cigarillos;Communities;cost;County;Data;Data Set;demographics;design;Development;Doctor of Philosophy;Education;ethnic minority;Ethnic Origin;experience;falls;Future;Goals;Health;health disparity;Heart Diseases;Human Resources;Income;Interview;Laws;Low income;Low Income Population;low socioeconomic status;manufacture;Marketing;Mentors;Mentorship;Methodology;Methods;Minority;mortality;Municipalities;novel;Persons;Policies;Policy Analysis;Population;Population Assessment of Tobacco and Health;Population Research;population survey;Price;Public Health;Quasi-experiment;Race;racial minority;Regulation;Reporting;Reproducibility;Research;Research Personnel;Risk;Sales;Scientist;sex;sociodemographic factors;sociodemographics;Statistical Data Interpretation;Stroke;Structure;System;Taxes;Tobacco;tobacco control;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;Tobacco-Related Carcinoma;Training;Vulnerable Populations;young adult;Youth

PROJECT_TITLE: The Impact of Cigar Pack Quantity on Tobacco Use Behavior


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE  A system-level perspective such as the medical legal partnership (MLP), resolves health harming legal needs (HHLNs) through clinical and legal partnerships and may prove beneficial for improving patient and clinic level health outcomes. This project applies a systems-level perspective via collaborative support from the Houston Health Equity Collective (key informant interviews) and the UTHealth MLP network (patient-informed quasi-experimental study) to address HHLNs in a low-income racially-ethnic diverse sample. Successful project completion will inform researchers, clinicians, and public health experts of how a systems-level prevention perspective care can resolve adverse needs and improve health-related outcomes in at-risk populations.

PI_NAMEs: JOHN, JEMIMA C (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: access restrictions;Address;adverse outcome;Area;Behavioral;Black race;care coordination;Caring;Childhood;Chronic;Clinic;Clinical;Color;Communities;community based participatory research;Complex;contextual factors;Continuity of Patient Care;COVID-19 pandemic;Data;Demographic Factors;Demographic Impact;Development;Disparity;Economics;Effectiveness;efficacy evaluation;Employment;Enrollment;Ensure;Environment;ethnic diversity;Ethnic Origin;Evaluation;experience;experimental study;Exposure to;falls;Family;Feedback;follow-up;Food;food insecurity;Geography;Health;health care quality;health care service utilization;health equity;Healthcare;Hispanic;Hispanic Populations;Household;Housing;housing instability;implementation evaluation;implementation outcomes;improved;Income;Individual;Inequity;informant;innovation;insight;Institution;Insurance;interest;intersectionality;Intervention;intervention participants;Interview;Joints;Knowledge;Knowledge acquisition;Legal;lens;Lived experience;Low income;Managed Care;Medical;medical examination;medical specialties;Mental Health;Mentored Research Scientist Development Award;Mentorship;Methodology;Minority Groups;Morbidity - disease rate;Neighborhoods;Outcome;Parents;Participant;Patient Care;patient oriented;Patients;pediatric patients;Physical environment;Physicians;Population;Populations at Risk;pragmatic study;Predictive Factor;Prevention;Process;programs;Protocols documentation;Public Health;public health priorities;Quality of life;Quasi-experiment;Race;racial diversity;Reach, Effectiveness, Adoption, Implementation, and Maintenance;remediation;Reporting;Research;Research Activity;Research Personnel;Resolution;Resources;Review Literature;Risk;Sampling;satisfaction;screening;social;Social Environment;social factors;social health determinants;Source;structural determinants;success;System;Time;Training;Transportation;trend;Uninsured;Visit;Voice;Work;years of life lost

PROJECT_TITLE: A systems-level perspective to addressing health harming legal needs via a joint Health Equity Collective and MLP network approach"


ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Narrative The human resource of trained researchers is a crucial component of successful biomedical research that can improve health and healthcare. Currently many potentially productive researchers coming out of undergraduate training choose other careers related to science or leave science because they have not experienced original research. Similarly, at primarily undergraduate colleges the research done by the fully research-trained faculty is limited by inadequate resource investment. NH-INBRE's programs would continue to support the further development of these underutilized human research resources and increase the research training of the workforce of New Hampshire.

PI_NAMEs: FIERING, STEVEN  (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: Behavior;Bioinformatics;biological research;Biomedical Research;Budgets;Cancer Education Grant Program;career;Career Choice;Cellular biology;Centers of Research Excellence;Characteristics;Collaborations;college;community college;Core Facility;Counseling;course module;Creativeness;Development;Education;Educational process of instructing;Educational workshop;Elements;Employment;Enrollment;Equipment;Evaluation;Evolution;Exposure to;Extramural Activities;Faculty;faculty mentor;Fostering;Funding;Genomic approach;Goals;graduate student;Grant;Health;Healthcare;higher education;Human;Human Resources;Immersion;improved;Incentives;industry partner;Infrastructure;Institution;instrumentation;Internships;Investigation;Investments;Laboratory Research;Learning;Maine;manufacture;Measures;Medical;medical schools;meetings;member;Mentors;microbial;Molecular Biology;multidisciplinary;National Center for Advancing Translational Sciences;National Institute of General Medical Sciences;Neurobiology;New Hampshire;Nurses;Nursing Students;Occupations;Pathogenesis;Persons;Postdoctoral Fellow;Principal Investigator;Process;Productivity;Program Research Project Grants;programs;recruit;regenerative;Research;research and development;Research Infrastructure;Research Personnel;Research Support;Research Training;Resources;Science;Scientist;Secure;Services;skills;Strategic Planning;student participation;Students;symposium;System;Teacher Professional Development;Technology;Touch sensation;Training;Translational Research;undergraduate student;United States National Institutes of Health;Universities;university student;Work;Workforce Development

PROJECT_TITLE: New Hampshire IDeA Network of Biomedical Research Excellence (NH-INBRE)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: GREEN, WILLIAM R (contact)

PROJECT_TERMS: Advisory Committees;American Association for the Advancement of Science;Attention;Award;Behavioral Sciences;Bioinformatics;Biomedical Research;career development;Collaborations;Committee Members;Communication;Counseling;Coupled;Creativeness;Data;Databases;design;Development;Educational workshop;Effectiveness;Ensure;Environment;Evaluation;Faculty;faculty mentor;Financial Support;Funding;Genomics;Goals;Grant;Health;Human;Human Resources;implementation process;improved;Individual;Infrastructure;Institution;Lead;Leadership;Link;meetings;member;Mentors;microbial;Mission;Modification;Molecular and Cellular Biology;Monitor;Movement;Neurobiology;New Hampshire;novel;Nursing Research;operation;organizational structure;Pathogenesis;Pilot Projects;Play;Policies;Positioning Attribute;Process;Program Evaluation;Program Research Project Grants;programs;Research;Research Personnel;Research Project Grants;Research Training;Rewards;Role;Schools;Science;Scientist;Services;Site Visit;sound;Strategic Planning;student training;Students;success;summer student;support network;Techniques;Time;tool;Training;Translations;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative: Ovarian Cancer (OCa) is the deadliest of all gynecologic cancers in the United States and a critical need exists for development of novel therapies treating OCa. With our expertise in developing novel small molecule inhibitors that disrupt protein-protein interactions, we have rationally designed and synthesized a small chemical molecule that function as LIFR inhibitor (EC359). The research proposed in this application is clinically significant because it will establish a mechanism and therapeutic potential of a first-in-class LIFR inhibitor EC359. This inhibitor can be utilized as a monotherapy, or as a combination therapy using in vitro and in vivo preclinical models; and thus, create a new paradigm of using LIFR inhibitor as a novel therapy for curbing OCa progression.

PI_NAMEs: NAIR, HAREESH BABU;VADLAMUDI, RATNA K (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Affinity;Apoptosis;Applications Grants;Biodistribution;Biological;biomarker identification;Biotechnology;Cancer Biology;cancer cell;Cancer Patient;cancer stem cell;cancer survival;Cardiovascular system;Cell model;Chemicals;Chemistry;Chemoresistance;chemotherapy;Clinical Treatment;Clinical Trials;clinically actionable;clinically significant;Collaborations;Combined Modality Therapy;Complex;cytokine;Cytotoxic Chemotherapy;Data;Data Set;Development;Disease Resistance;Dose;drug development;efficacy evaluation;efficacy study;Environment;Exhibits;experience;Family;Formulation;FRAP1 gene;Genomics;Geography;glycoprotein 130;Goals;Grant;Growth;Health;humanized mouse;In Vitro;in vivo;Industry;industry partner;inhibitor;Interleukin-6;Investigational Drugs;Investigational New Drug Application;leukemia inhibitory factor receptor;LIF gene;Ligands;Macrophage;Maintenance Therapy;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;manufacture;MAP Kinase Gene;Maximum Tolerated Dose;member;method development;Modeling;Molecular;mouse model;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel therapeutics;oncostatin M;Operative Surgical Procedures;Patients;Pharmaceutical Preparations;Play;Pre-Clinical Model;protein protein interaction;Proteomics;Proto-Oncogene Proteins c-akt;Protocols documentation;rational design;Receptor Signaling;receptor-mediated signaling;Recurrence;Recurrent tumor;Research;Resistance;Role;Safety;screening;Signal Pathway;Signal Transduction;small molecule inhibitor;standard of care;STAT3 gene;stemness;targeted treatment;Testing;Texas;The Cancer Genome Atlas;Therapeutic;Therapeutic Effect;therapy resistant;Toxic effect;Translations;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;United States;Universities;Xenograft Model

PROJECT_TITLE: Novel targeted therapy for treating Ovarian Cancer


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome

PROJECT_TERMS: Acceleration;Address;Bioinformatics;Biology;Biomedical Research;Cancer Education Grant Program;Collaborations;computer infrastructure;cost effective;Data;Data Analyses;Data Science;Development;Education;Educational Curriculum;Educational process of instructing;Ensure;Evaluation;Evolution;experience;Experimental Designs;Faculty;FAIR principles;Fostering;Funding;Future;Generations;Genomics;Geographic Locations;Goals;Grant;improved;informatics training;innovation;Institution;Kansas;Lead;Measures;Methods;New Hampshire;Phase;programs;Publications;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Science;skills;Strategic Planning;student training;success;Teacher Professional Development;Trainers Training;Training;Training Activity;Training and Infrastructure;Training Programs;undergraduate student;United States National Institutes of Health;Universities;Workforce Development

PROJECT_TITLE: Bioinformatics and Genomics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Rare Diseases;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: Project Narrative The proposed research aims to unravel the physiological basis of vasomotion-mediated perivascular clearance of amyloid β from the brain. We will use complementary state-of-the-art in vivo neuroimaging techniques to study vasomotion and fluid flow dynamics in experimental mouse models and human individuals with and without cerebral amyloid angiopathy. This research will contribute to further our understanding of the fundamental properties of perivascular waste clearance and will provide much needed proof-of-concept data to design future studies aimed at enhancing vasomotion to promote drainage and maintain brain health during aging.

PI_NAMEs: VAN VELUW, SUSANNE JANNEKE (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: abeta accumulation;Abeta clearance;abeta deposition;Acceleration;Affect;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease diagnosis;Amyloid beta-Protein;Arteries;arteriole;Automobile Driving;awake;Blood capillaries;blood oxygen level dependent;Blood Vessels;Brain;brain health;brain tissue;Calcium;Cell Physiology;Cells;Cephalic;Cerebral Amyloid Angiopathy;Cerebral hemisphere hemorrhage;Cerebrospinal Fluid;cerebrospinal fluid flow;Cerebrovascular system;Chronic;clinical diagnosis;Coupled;Coupling;Data;Dementia;Deposition;design;Dextrans;Disease;disease model;Drainage procedure;driving force;Early Intervention;effective therapy;Elderly;Event;experimental study;fluid flow;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Future;Genes;hemodynamics;Hemorrhage;High Prevalence;Human;Image;Imaging Techniques;Immunotherapy;Impaired cognition;Impairment;improved;in vivo;in vivo optical imaging;Individual;Injections;innovation;Intercellular Fluid;Intervention;Label;Leptomeninges;Literature;Lobar;Measures;Mediating;Metabolic;Methods;Modeling;mouse model;Mus;neuroimaging;new therapeutic target;non-invasive imaging;novel;Nutrient;optical imaging;optogenetics;Oxygen;particle;Pathway interactions;Patients;Pattern;Photic Stimulation;Physiological;Physiology;Play;preservation;prevent;Process;Property;Research;Resolution;Rest;Risk;Role;Severities;single-cell RNA sequencing;Smooth Muscle Myocytes;solute;Speed;System;Techniques;Testing;therapeutic development;Time;Tracer;transcriptomics;Transgenic Mice;translational approach;Translations;two photon microscopy;Vascular Diseases;Vascular Smooth Muscle;vasomotion;Visual;Waste Products;wasting;Work

PROJECT_TITLE: Mechanisms of Vasomotion-mediated Perivascular Clearance in Cerebral Amyloid Angiopathy


ORG_CITY: COLUMBIA

ORG_NAME: SC STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: SC

PHR: South Carolina Department of Agriculture Consumer Protection Division 123 Ballard Court, West Columbia, SC 29172  Hugh E. Weathers, Commissioner Project Narrative Project Name: Advancement of the Produce Safety Rule by the South Carolina Department of Agriculture through the FDA’s Cooperative Agreement Program for Produce Safety, Path C Funding Opportunity Announcement Number: PAR-21-174 Principal Investigator Produce Safety Manager Elizabeth “Betsy” Dorton Kelly Johnson Office #: (803) 734-0467 Office #: (803) 753-7267 Email: bdorton@scda.sc.gov Cell#: (843) 845-7707  Email: kjohnson@scda.sc.gov The South Carolina Department of Agriculture (SCDA) is dedicated to further advancing their efforts of educating and regulating South Carolina produce farms on the Produce Safety Rule. Through education, outreach, inspections, compliance and enforcement our mission of this 5-year project is to reduce foodborne illnesses by enhancing the safety in growing, harvesting, packing, and storing fresh fruits and vegetables.

PI_NAMEs: DORTON, ELIZABETH  (contact)

PROJECT_TITLE: Path C Advancement of the Produce Safety Rule by the South Carolina Department of Agriculture through the FDA's Cooperative Agreement Program for Produce Safety, Path C


PROJECT_TERMS: Accounting;Address;Advisory Committees;American Association for the Advancement of Science;Award;Bioinformatics;Biomedical Research;Budgets;Collaborations;Committee Members;Communication;community college;Complex;Decision Making;Development;Disparate;Enrollment;Equipment;Evaluation;Evolution;experience;Faculty;Faculty Recruitment;faculty research;Funding;Genomics;Goals;Grant;improved;Individual;Infrastructure;Institution;Lead;Leadership;member;Mentors;New Hampshire;novel;novel strategies;operation;Postdoctoral Fellow;Privatization;Process;Program Research Project Grants;programs;Research;Research Activity;research faculty;Research Infrastructure;Research Personnel;Research Support;Research Training;Resources;Schools;Science;service delivery;Service provision;Services;Strategic Planning;student mentoring;Students;System;Training;Training and Education;Training Programs;undergraduate student;Universities

PROJECT_TITLE: Research Training Core


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Mental Illness;Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Opioid addiction is a growing pandemic that lacks treatment capable of producing long-lasting abstinence. This project aims to examine the role of individual lateral habenula neurons in memory and cognitive flexibility using calcium imaging methods in freely behaving rats undergoing opioid addiction and withdrawal. Uncovering individual neuron contributions to the processes underlying addiction, as well as the neural and behavioral response to psilocybin, will generate greater understanding of the basic neural mechanisms underlying cognition and how these mechanisms become dysfunctional during opioid addiction.

PI_NAMEs: HONES, VICTORIA IVANOVA (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Abstinence;addiction;Adult;Affect;Alcohol dependence;Anhedonia;Anxiety;Architecture;Attenuated;Behavior;Behavioral;behavioral response;brain remodeling;brain tissue;Calcium;Cells;Chronic;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive performance;cognitive system;cognitive task;cognitive testing;conventional therapy;Development;Electrophysiology (science);Epithalamic structure;Exhibits;experimental study;Feasibility Studies;flexibility;Functional disorder;Genetic Transcription;Habenula;HTR2A gene;Human;Hyperactivity;Image;imaging modality;Imaging technology;Impaired cognition;Impairment;improved;Individual;Lateral;maladaptive behavior;Memory;Memory impairment;Mental Depression;Mental disorders;Methods;Monitor;Morphine;Morphine Dependence;mu opioid receptors;Naloxone;neural;neural circuit;neural correlate;neuromechanism;Neurons;Nicotine Dependence;novel;object recognition;Opiate Addiction;Opioid;Opioid replacement therapy;opioid withdrawal;Overdose;pandemic disease;Performance;Pharmaceutical Preparations;Population;Process;Psilocybin;psychiatric symptom;Psychopathology;Rattus;receptor;receptor expression;Relapse;Research;response;Reversal Learning;Risk;Rodent;Rodent Model;Role;Series;Serotonin Agonists;serotonin receptor;Signal Transduction;Structure;Study models;Symptoms;System;Testing;Time Series Analysis;Withdrawal

PROJECT_TITLE: Neural Signatures and Cognitive Performance During Rat Morphine Withdrawal, and Subsequent Impact of Psilocybin


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Substance use often emerges during early adolescence. In some individuals, it progresses to problematic use and use disorder. Liability to develop substance use disorders is shaped by genomic and environmental influences that operate via several mechanisms, including neurobiological pathways associated with behavioral vulnerability. We utilize the ABCD data, along with several other samples that uniquely extend the temporal scope of ABCD to comprehensively examine brain-behavior developmental interplay related to substance use and misuse.

PI_NAMEs: AGRAWAL, ARPANA ;BOGDAN, RYAN H (contact)

PROGRAM_OFFICER_NAME: KIMMEL, HEATHER L

PROJECT_TERMS: Accounting;addiction;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Age;Alcohols;Architecture;association cortex;Attenuated;Behavior;behavior prediction;Behavioral;Behavioral Mechanisms;behavioral phenotyping;Brain;brain behavior;burden of illness;Cessation of life;Childhood;cognitive control;cognitive development;cognitive reappraisal;comorbidity;coping;Corpus striatum structure;Cues;Data;Data Analyses;Development;Disease;disease classification;disorder risk;early adolescence;early onset substance use;economic cost;Education;emerging adult;emotion regulation;Emotional;Emotions;Environment;Environmental Exposure;Environmental Risk Factor;Etiology;executive function;fetal substance exposure;Genetic;genetic risk factor;Genomics;improved;Impulsivity;indexing;Individual;Intoxication;Investigation;Link;Machine Learning;Maintenance;Manuscripts;Mediating;Methods;Modeling;multimodality;negative affect;neural;neural correlate;neurobehavioral;Neurobiology;neurodevelopment;neuromechanism;novel;Occupations;Pathway interactions;Pattern;Phenotype;Policies;polygenic risk score;prenatal;Prevention;Risk;Risk Factors;risk sharing;Risk Taking;Sampling;Shapes;Siblings;social;socioeconomics;Structure;substance misuse;substance use;Substance Use Disorder;Testing;theories;Thick;Tobacco;Twin Multiple Birth;Variant;Withdrawal;young adult;Youth

PROJECT_TITLE: Neurobehavioral pathways of polygenic and polyenvironmental effects on the onset and maintenance of substance involvement

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


PROJECT_TERMS: Address;Advisory Committees;American Association for the Advancement of Science;Applications Grants;Area;Award;Biomedical Research;career development;Collaborations;Committee Members;Communication;Counseling;Data;Development;Eligibility Determination;Evaluation;Evolution;expectation;experience;Faculty;Feedback;formative assessment;Funding;Funding Opportunities;Goals;Grant;Grant Review;Guidelines;improved;Incentives;Institution;interest;Lead;Leadership;Learning;Letters;meetings;member;Mentors;Modification;National Institute of General Medical Sciences;New Hampshire;Paper;Peer Review;Pilot Projects;Principal Investigator;probation;Process;professor;Program Evaluation;Program Research Project Grants;programs;Progress Reports;Publishing;Recommendation;recruit;Reporting;Research;Research Activity;research and development;Research Project Grants;Research Proposals;Research Support;Resources;response;Role;Schools;Science;Solid;student participation;student training;Students;undergraduate research experience;undergraduate student;Writing

PROJECT_TITLE: Developmental Research Project Program


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: FLORIDA ASSN OF PEDIATRIC TUMOR PROG

ORG_STATE: FL

PHR: Project Narrative The Florida Pediatric NCORP will maintain its single focus to make the latest advances in cancer care available to large segments of Florida through participation in treatment, cancer control and CCDR trials through its affiliation with the Children’s Oncology Group.

PI_NAMEs: KRISCHER, JEFFREY P;SALMAN, EMAD  (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: African American;Applications Grants;base;Black American;Cancer Burden;cancer care;Cancer Control;care delivery;Caring;chemotherapy;Child;Childhood;Clinical Trials;Communication;Communities;Community Clinical Oncology Program;Community Hospitals;Community Participation;Country;County;data quality;Development;Diagnosis;Eligibility Determination;Enrollment;Ensure;Family;Florida;General Hospitals;Geography;Goals;Grant;Health;Hispanic;Home;Hospitals;Latino;Mainstreaming;Malignant Neoplasms;member;Minority;Operative Surgical Procedures;participant enrollment;Pathology;patient population;Patients;Patterns of Care;Pediatric Hospitals;Pediatric Oncology;Pediatric Oncology Group;Population;Population Intervention;Procedures;programs;Protocol Compliance;Protocols documentation;Quality Control;Quality of Care;Radiation therapy;Research;research based treatment;Risk Factors;Science;Site;success;Treatment Protocols

PROJECT_TITLE: The Florida Pediatric NCORP renewal application for grant# UG1CA189973 to continue participation in the NCI Community Oncology Research Program.


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Global estimates of violence against women (VAW) suggest that one in three women will experience intimate partner violence (IPV) in their lifetime and that these women are much more likely to experience psychological distress, but recent research suggests that closer to 85% of women in informal settlements in Nairobi, the capital city of Kenya, experience IPV in their lifetime. Health polices in Kenya call for strategies to respond to and reduce VAW and co-occurring mental health disorders; thus, the proposed project will: 1) adapt a combined IPV screening, brief intervention and referral to treatment and mental health intervention (WINGS+PM+) that can be carried out by lay community health workers as a foundation for a potential low-cost essential services package for women experiencing IPV and related mental health challenges in informal settlements in Kenya and 2) assess the feasibility, safety, and acceptability of the intervention in an existent healthcare setting in Kibera—a large informal settlement in Nairobi. This project advances IPV response intervention by providing a low-cost combined IPV and mental health response intervention that has the potential to expand critical services to women experiencing IPV in informal settlements—women who are more likely to be experiencing IPV and less likely to have access to these services—and to help reduce IPV and psychological distress for these women.

PI_NAMEs: WINTER, SAMANTHA C. (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Africa;Anxiety;Applications Grants;Area;Capital;career;career development;Cities;Clinic;Collaborations;Communities;community advisory board;community consultation;community engagement;Community Health;Community Health Aides;cost;Data;design;Development;Development Plans;Distal;Educational workshop;effective intervention;efficacy trial;Elements;experience;Feasibility Studies;Focus Groups;Fogarty International Center;Foundations;global health;Goals;Guidelines;hands on research;Health;health care settings;Health Personnel;Health Priorities;Health Services;Health Services Accessibility;Health system;Housing;implementation intervention;Infrastructure;International;Interpersonal Violence;Intervention;intervention cost;Interview;intimate partner violence;Kenya;life span;longitudinal analysis;low and middle-income countries;Manuscripts;Mediator;meetings;member;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentored Research Scientist Development Award;Mentors;Methodology;Modeling;Morbidity - disease rate;mortality;National Health Policy;neighborhood disadvantage;novel;Outcome;Persons;pilot test;Police;Policies;Population;post-traumatic stress;Post-Traumatic Stress Disorders;Prevalence;Prevention;programs;Protocols documentation;psychologic;psychological distress;Psychosocial Assessment and Care;Public Health;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reporting;Research;Research Personnel;Resource-limited setting;response;Risk;Risk Reduction;Safety;safety assessment;Science;Scientist;screening;screening, brief intervention, referral, and treatment;Secure;Self Efficacy;Service provision;Services;sexual violence;skills;Social support;Statistical Data Interpretation;Strategic Planning;Suicide attempt;Survivors;Testing;Training;treatment arm;treatment program;United States National Institutes of Health;Violence;violence against women;violence victimization;volunteer;Wing;Woman;women subjects;Women's Health;Writing

PROJECT_TITLE: Adapting a low-cost intimate partner violence (IPV) and mental health response intervention for women in informal settlements in Kenya

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-L(57)R]


ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Axon degeneration is a hallmark of neurodegenerative diseases; my preliminary data demonstrate lactate accumulation may drive axon degeneration, however, the molecular mechanism by which this occurs is unknown. Work proposed here will establish the role of lactate in axon degeneration and further our understanding of the coupling between neuronal activity and lactate in health and disease. This new mechanistic insight could point toward lactate-intervention as a therapy for the prevention of neurodegeneration.

PI_NAMEs: TAL, HADAS  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: academic preparation;Acidosis;age related;Animals;Automobile Driving;Auxins;Axon;axonal degeneration;Back;Bacteria;Behavior;Binding;Biological Assay;Biology;Caenorhabditis elegans;career;Cell Death;Cells;Cellular biology;combat;Coupling;Custom;Data;Disease;driving force;Early Intervention;Environment;Enzymes;Exhibits;experimental study;Fellowship;Fluorescence Resonance Energy Transfer;Genetic Research;Glycolysis;Glycolysis Inhibition;Health;Homologous Gene;Human;improved;in vivo;Individual;inhibitor;insight;Intervention;Kinesin;lactate dehydrogenase 1;lactate dehydrogenase A;Lactate Transporter;Lactic acid;Link;Locomotion;Metabolism;Microscope;Mitochondria;Modeling;Molecular;Morphology;mutant;Nerve Degeneration;Neurodegenerative Disorders;neuronal metabolism;Neurons;Neurosciences;novel strategies;older adult;optogenetics;overexpression;Pathology;Pharmaceutical Preparations;Phenotype;prevent;Prevention;Prevention therapy;Process;Production;Pyruvate Metabolism Pathway;Research;Role;sensor;skills;System;Testing;tool;trafficking;Training;Work

PROJECT_TITLE: Defining the Role of Lactate in Axon Degeneration


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Synucleinopathies such as Parkinson’s Disease, Lewy body dementia and multiple system atrophy affect millions of Americans and yet they lack proper disease modifying treatments. The goal of this proposal is to investigate the role of UBQLN2 in clearing a-synuclein in normal and disease states. The completion of this study will lead to a better understanding of protein quality control as it pertains to disease and in the process potentially reveal novel therapeutic targets for neurodegenerative disease.

PI_NAMEs: SANDOVAL-PISTORIUS, STEPHANIE SUZETTE (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Affect;age related;age related neurodegeneration;aging brain;alpha synuclein;Alpha-Synuclein transgenic mouse;Alzheimer's disease related dementia;American;Autophagocytosis;Binding;Biochemical;Biological Markers;Brain Diseases;C-terminal;career;Cell Line;Cell model;Cells;Cellular Assay;Chronic;Dementia;Disease;disease phenotype;Electroencephalography;Engineering;experience;experimental study;Faculty;Family;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Goals;human disease;Implant;In Vitro;in vivo;Institution;Investigation;knock-down;Knock-out;Knockout Mice;Knowledge;Laboratories;Length;Lewy Body Dementia;link protein;Literature;Measures;Mediating;Methods;Missense Mutation;Modeling;Molecular;Molecular Chaperones;mouse model;mouse synuclein alpha;Movement Disorders;multicatalytic endopeptidase complex;Multiple System Atrophy;Mus;mutant;Mutation;N-terminal;Neurodegenerative Disorders;neuropathology;neurophysiology;neurotoxicity;new therapeutic target;novel therapeutics;overexpression;Parkinson Disease;Pathogenicity;Pathology;Pathway interactions;pharmacologic;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Process;Proline-Rich Domain;Proteasome Binding;protein aggregation;protein degradation;Proteins;proteostasis;Quality Control;Reagent;Regulation;Research;Role;Route;Scientist;sex;skills;synuclein;synucleinopathy;System;Techniques;tenure track;Testing;Training;Transgenic Mice;UBA Domain;ubiquilin;Ubiquitin;Wild Type Mouse;Work

PROJECT_TITLE: An investigation into chronic implanted subgaleal electroencephalography for neurophysiological biomarker tracking in movement disorders


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Hematology;Lymphatic Research;Lymphoma;Machine Learning and Artificial Intelligence;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Most current methods for the fundamental image analysis task of object segmentation have focused on a small group of objects and were designed to operate on a specific imaging modality - an approach that is not sustainable and becomes a stumbling block when dealing with whole-body systemic diseases where body- wide image analysis is called for. The main goal of this project is to develop a body-wide and generalizable image segmentation and analytics methodology that is based on creating a comprehensive family of body-wide anatomic models covering the entire adult human age spectrum and performing disease quantification without explicitly delineating objects. The project will apply this methodology to the study of patients with diffuse large B cell lymphoma (DLBCL), a common subtype of lymphoma, for which PET-based staging and response assessment/ prediction is of paramount importance clinically.

PI_NAMEs: SCHUSTER, STEPHEN J;TORIGIAN, DREW ;UDUPA, JAYARAM K (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: 3-Dimensional;Abdomen;Adult;Affect;Age;age group;age related;Aging;Agreement;Anatomic Models;Anatomy;Automation;Body Burden;Body Regions;burden of illness;Chest;Clinical;Computer software;Data;Data Set;Databases;deep learning;design;Development;Diagnosis;Diagnostic;Disease;Engineering;Family;Female;fluorodeoxyglucose positron emission tomography;Gender;Geography;Goals;Image;Image Analysis;imaging modality;imaging Segmentation;improved;Individual;innovation;Institution;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;Lesion;lymph nodes;Lymphoma;male;Manuals;Measurement;Measures;Medical Imaging;Medicine;Methodology;Methods;Modeling;Monitor;Names;Neck;New York;Normalcy;object recognition;Organ;Outcome;outcome prediction;Pathologic;Pathology;Patients;Pelvis;Performance;PET/CT scan;Population;Positron-Emission Tomography;predict clinical outcome;predicting response;prediction algorithm;Process;Prognosis;prognostication;Protons;quantitative imaging;Radiology Specialty;Reproducibility;response;Sampling;Scanning;Specificity;Staging;Standardization;Systemic disease;task analysis;Techniques;Testing;theories;Therapeutic Intervention;Time;Training;training data;virtual;X-Ray Computed Tomography

PROJECT_TITLE: Models and methods for automatically measuring disease body-wide and staging disease via FDG-PET/CT in Lymphoma

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Natural killer (NK) cells play a key role in early control of HIV infection and we have recently uncovered that in people living with HIV, a subset of memory NK cells can specifically recognize and efficiently eliminate cells presenting peptide antigens derived from HIV. This proposal is designed to comprehensively determine the mechanisms regulating the development and function of memory NK cells with potent anti-viral activity. The outcome of these investigations will provide the rationale to harness memory NK cells for vaccine design, curative or other therapeutic interventions against HIV.

PI_NAMEs: JOST, STEPHANIE ;REEVES, ROGER KEITH (contact)

PROGRAM_OFFICER_NAME: BOGGIANO, CESAR AUGUSTO

PROJECT_TERMS: Address;Antibodies;Antibody-Dependent Enhancement;Antigens;Autologous;B-Lymphocytes;Binding;Cell Line;Cell Physiology;Cells;Clonal Expansion;Cytomegalovirus;Cytotoxic T-Lymphocytes;Data;design;Development;Disparate;Effector Cell;Epigenetic Process;Epitopes;Exhibits;Exposure to;Future;Gene Expression Profile;Genetic Transcription;Helper-Inducer T-Lymphocyte;HIV;HIV Antigens;HIV Infections;HIV vaccine;Hour;Human;Immune;immune function;In Vitro;in vivo;Infection;Infectious Agent;Influenza;Innate Immune System;interest;Investigation;Kinetics;KLRD1 gene;Laboratories;Ligands;Mediating;Memory;Metabolic;Molecular;Molecular Profiling;mouse model;Mus;Natural Killer Cells;nonhuman primate;Outcome;Pathway interactions;Peptides;Persons;Play;prevent;Primates;programs;protective effect;receptor;Reporting;response;Role;Sampling;sensitizing antigen;single-cell RNA sequencing;SIV;Specificity;T-Lymphocyte;Therapeutic Intervention;Vaccination;Vaccine Design;Viral;Viral Physiology;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Fine Mechanisms of Adaptive NK Cell Formation Against HIV and SIV


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: AMHERST

ORG_DEPT: PHYSIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative Metabolic acidosis is common in chronic kidney disease (CKD), and contributes to progression of kidney disease and the development of cardiovascular disease; the latter of which is the leading cause of mortality in patients with CKD. This project aims to understand the impact of cellular level acid-base transport on the cardiorenal response to acidosis. Since renal and cardiac outcomes in CKD are intertwined, this project has immediate impact on the understanding of CKD pathophysiology.

PI_NAMEs: BRADY, CLAYTON TIMOTHY (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: absorption;Acid-Base Equilibrium;Acidosis;Acids;Address;Adult;Amino Acid Sequence;Ammonia;Animals;base;Bicarbonates;Blood gas;Body Weight;Cardiac;Cardiac Myocytes;Cardiology;Cardiovascular Diseases;Catheterization;Cause of Death;Cells;Chronic;Chronic Kidney Failure;Circulation;Clinical;Clinical Trials;Data;Development;Disease;Disease Progression;Echocardiography;Electrocardiogram;Evaluation;Excretory function;experience;experimental study;Fellowship;Functional disorder;Goals;Growth;Heart;Heart failure;heart function;Heart Hypertrophy;Histologic;Homeostasis;Immunohistochemistry;Impairment;in vivo;insight;Investigation;Ion Transport;Kidney;Kidney Diseases;Knock-out;Knockout Mice;Knowledge;knowledge integration;Laboratories;Left;Link;Measurement;medical schools;Mentorship;Metabolic acidosis;Microscopy;Modeling;Molecular;mortality;Mus;Nephrology;Outcome;Patients;Phenotype;Physicians;Physiologic intraventricular pressure;Population;Preceptorship;pressure;prevent;Promoter Regions;Proximal Kidney Tubules;Regulation;Renal function;Research;Respiratory Acidosis;response;Risk Factors;Role;Science;Scientist;Series;Serum;symporter;System;Testing;Training;Universities;Variant;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: Investigating the role of NBCe1-B in renal and cardiac acid-base handling


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project narrative: Telomere and centromere dysfunction can occur upon exposure to chronic oxidative stress that triggers DNA damage and genome instability, a hallmark of many human diseases including cancer. This proposal is designed to decipher the mechanisms by which oxidative stress impacts these two genomic loci and delineate the roles played by DNA repair proteins PARPs in their protection. The data collected will ultimately contribute to the design of novel telomere and centromere-centric therapeutic strategies for the treatment of oxidative stress- driven human diseases.

PI_NAMEs: FOUQUEREL, ELISE  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Air Pollution;Antioxidants;base;Base Excision Repairs;cancer therapy;cancer type;Centromere;Chromosomal Instability;Chromosomes;Chronic;cigarette smoke;Data;design;Development;DNA;DNA Damage;DNA Repair;DNA Repair Gene;Enzymes;epidemiology study;Excision Repair;Exposure to;Functional disorder;Genome;Genome Stability;Genomic Instability;genomic locus;Goals;Health;Human;human disease;Inherited;innovation;insight;Knowledge;Lesion;Link;Malignant Neoplasms;Mediating;mitochondrial metabolism;Mutation;novel;novel therapeutic intervention;oxidative DNA damage;Oxidative Stress;Pathway interactions;Phenotype;Play;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Post-Translational Protein Processing;Premature aging syndrome;Production;Proteins;rational design;Reactive Oxygen Species;recruit;Rest;Role;segregation;Single Strand Break Repair;Source;telomere;Therapeutic;tool;treatment strategy;Ultraviolet Rays;Work

PROJECT_TITLE: Mechanistic insight into oxidative stress-mediated genome instability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Narrative We propose to build a program that will support students from Malcolm X College (MXC), a two-year institution, prior to, during, and after their transfer to University of Illinois at Chicago (UIC), a four-year institution and a Research I university. The program will introduce students to life sciences, cancer research, and health disparities and support them with their coursework and research experiences with mentors from UIC. At both MXC and UIC, this program builds in faculty development for affiliated mentors and institutional reprogramming to create a more inclusive educational experience.

PI_NAMEs: GRIPPO, PAUL J;GRUDZIEN, PETER ;WINK, DONALD J. (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Address;Admission activity;anti-cancer research;Attention;Biomedical Research;bridge to the baccalaureate;cancer health disparity;career;Chicago;college;Communities;community college;Development;Education;Educational process of instructing;Educational workshop;Ethics;experience;Faculty;health disparity;Healthcare;Illinois;Institution;instructor;Laboratories;Mentors;Methodology;Mission;Monitor;programs;recruit;Research;research and development;Research Methodology;Research Personnel;Research Training;Science;Structure;Students;summer research;symposium;Talents;Teacher Professional Development;Training;Training Programs;undergraduate student;underrepresented minority student;Universities;Voice

PROJECT_TITLE: Bridges to the Baccalaureate Research Training Program at University of Illinois at Chicago

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: IOWA CITY

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Narrative  This project will determine how stem cell niches within the craniofacial/dental complex are activated by Lef-1 and compartmentalized by miR-26b expression. Stem cells within these compartments will be isolated and the epigenetic, miRNA and gene expression signatures identified. The knowledge gleaned from these experiments will be applied to reprogramming adult oral epithelial cells to different types of dental and oral stem cell progenitors capable of repairing and regenerating specific craniofacial and dental tissues affected by disease, injury or genetic anomalies.

PI_NAMEs: AMENDT, BRAD A (contact);CAO, HUOJUN

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Adult;Affect;Architecture;Artificial Organs;Binding;Bioinformatics;Biological Assay;Biomedical Engineering;Bromodeoxyuridine;cell behavior;Cell Compartmentation;Cell Differentiation process;Cell division;cell injury;Cell Line;Cell Maintenance;Cell Proliferation;cell type;Cells;Cervical;ChIP-seq;Complex;craniofacial;Daughter;daughter cell;Defect;Dental;Dental Enamel;Development;Disease;Embryo;Embryonic Development;Enhancers;Epigenetic Process;Epithelial Cells;epithelial stem cell;Epithelium;experimental study;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Genomics;Glean;Goals;Growth;Human;In Situ Hybridization;in vivo;Incisor;injured;Injury;knock-down;Knockout Mice;Knowledge;Life;Lung;Mesenchyme;MicroRNAs;Molecular;morphogens;mouse model;Mus;Natural regeneration;novel therapeutics;Odontoblasts;Odontogenesis;Oral;oral cavity epithelium;oral tissue;Organ;Outcome;overexpression;Pathway interactions;Pattern;Phenotype;Pluripotent Stem Cells;Population;Process;Production;progenitor;programs;Proliferating;regenerative;Regulation;Regulatory Pathway;repaired;Reporter;Repression;Role;Signal Pathway;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Stains;stem;stem cell differentiation;stem cell expansion;Stem Cell Factor;stem cell function;stem cell niche;stem cell proliferation;stem cells;Testing;tissue regeneration;Tissues;tool;Tooth regeneration;Tooth structure;Trachea;transcription factor;transcriptome;transcriptome sequencing;Western Blotting;Work

PROJECT_TITLE: Co-opting Lef-1 and miR-26b activities to regulate dental stem cells and their progeny

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Methamphetamine;Neurosciences;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE  This research will generate a novel line of high-impact evidence regarding connections among methamphetamine use, social relationships, and cognitive functioning among people with HIV across the life course (ages 18-87) and will highlight pathways to develop interventions to maintain brain health for this population. The Principal Investigator will utilize innovative and rigorous statistical methods including time-varying effect modeling and cross-lagged structural equation modeling by leveraging the NIH’s previous and ongoing investments in HIV and methamphetamine research at the University of California, San Diego. An understanding of how social relationships mediate the impacts of HIV and methamphetamine use on cognitive function across the life span can inform future treatment responses and care interventions designed to reduce substance use and negative impacts on cognitive function among people with co-occurring HIV and substance use disorders.

PI_NAMEs: BENDER, ALEXIS ANNE (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescence;Adult;Age;Age Years;Aging;Area;Award;biological age;brain health;California;Caring;co-infection;cognitive change;cognitive function;cohort;comorbidity;Data;Data Set;Drug Addiction;Drug usage;Emotions;Ensure;Equation;experience;Family;Funding;Future;HIV;HIV Infections;Impaired cognition;improved;Individual;innovation;insight;Intervention;Investments;Knowledge;Life Cycle Stages;life span;longitudinal analysis;longitudinal database;Longitudinal Studies;Measurement;Measures;Mediating;Mental Health;Mentors;Methamphetamine;methamphetamine use;Methamphetamine use disorder;Methods;Modeling;Multivariate Analysis;National Institute of Drug Abuse;National Institute of Mental Health;neurobehavioral;Neurocognitive;Neurocognitive Deficit;novel;Older Population;Pathway interactions;peer;Persons;physical conditioning;population health;Positioning Attribute;Principal Investigator;psychosocial;Publications;Qualitative Methods;reduced substance use;Research;Risk Factors;Sampling;Scientific Advances and Accomplishments;Scientist;skills;social relationships;Social support;Societies;Statistical Methods;Statistical Models;Strategic Planning;substance use;Substance Use Disorder;success;therapy design;therapy development;Time;Training;treatment response;United States National Institutes of Health;Universities;Validity and Reliability;Variant;Vulnerable Populations;young adult

PROJECT_TITLE: A longitudinal analysis of methamphetamine use, social relationships, and cognitive function among people living with HIV

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Physical Activity;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE The public health significance of our proposed ENRICH intervention is high, given the aging population and the poor outcomes experienced by older adults recovering from hip fracture. The patient-centered development and implementation of the ENRICH program represents an important paradigm shift in hip fracture rehabilitation, and provides a framework for promoting high quality aging in place for other disabled older adult populations.

PI_NAMEs: FALVEY, JASON RAYMOND (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Aging;aging in place;aging population;Award;Baltimore;built environment;career;career development;Caring;Censuses;Characteristics;clinical care;Communities;community engagement;Conduct Clinical Trials;Data;Data Analyses;Development;disability;disabled;Disadvantaged;Durable Medical Equipment;Elderly;Environment;Equipment;exercise training;experience;feasibility trial;Funding;Goals;health care disparity;Health care facility;Health Status;Hip Fractures;Hip region structure;Home;Home Care Services;Home Nursing Care;Hospitalization;Housing;improved;Individual;information gathering;Infrastructure;Intervention;intervention refinement;Interview;Link;longitudinal analysis;Maryland;medical schools;Medicare claim;Mentors;Mentorship;Methods;Mission;Mobility disability;Modeling;Municipalities;National Institute on Aging;neighborhood association;neighborhood disadvantage;Neighborhoods;novel;older adult;Older Population;Outcome;Outcomes Research;patient engagement;patient oriented;Patient-Focused Outcomes;Patients;peer;peer coaching;Physical activity;physical therapist;pilot test;Population;Population Heterogeneity;Positioning Attribute;Process;programs;Protocols documentation;Public Health;Recommendation;Recovery;Rehabilitation therapy;Research;Research Training;Resources;Risk Assessment;Scientist;Screening procedure;Self-Help Devices;Services;Site;skills;socioeconomic disadvantage;successful intervention;Survivors;Testing;Training;Transportation;treatment as usual;Universities;Work

PROJECT_TITLE: The ENRICH Study: Engaging Community and Municipal Services to Promote High Quality Aging in Place After Hip Fracture


ADMINISTERING_IC: AI

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunotherapy;Patient Safety;Prevention;Skin Cancer

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE In this proposal, we will prospectively evaluate the immune-related adverse events, symptom burden, and immunological correlates in patients receiving adjuvant therapy with immune checkpoint inhibitors in clinical practice. The study will use validated patient reported outcomes and ecological momentary assessments method that have not been reported before in this setting. Our findings will inform recommendations on clinical assessments and management of toxicity and symptom burden, risk-benefit considerations, and provide a solid foundation for further translational and clinical research in this area.

PI_NAMEs: HASSAN, NOHA ABDELWAHAB HASSAN ALI (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute;acute toxicity;Adjuvant;Adjuvant Therapy;Adverse effects;Adverse event;adverse event risk;Advisory Committees;anti-cancer research;Area;associated symptom;Autoimmune;Autoimmune Diseases;Autoimmunity;Behavioral;Behavioral Sciences;Benefits and Risks;Biological Response Modifiers;biomarker identification;Biometry;Cancer Center;Cancer Patient;Cancer Survivor;Cancer Survivorship;career development;Caring;Cell Therapy;Cells;checkpoint therapy;Chronic;Clinical;Clinical assessments;clinical care;Clinical Immunology;Clinical Management;clinical phenotype;clinical practice;Clinical Research;Clinical Trials;Committee Members;cytokine;Data;Data Collection;Development;Development Plans;Disease;Ecological momentary assessment;Effectiveness;Environment;Epidemiologist;Epidemiology;experience;Fatigue;follow-up;Foundations;Future;Genes;Genetic;Genetic Markers;Genetic Risk;Goals;Health Services Research;high risk;Immune;immune activation;Immune checkpoint inhibitor;Immune system;immune-related adverse events;Immunobiology;Immunologic Adjuvants;Immunologics;Immunology;Incidence;Inflammation;Inflammatory;Inflammatory Response;innovation;instrument;Interleukin-6;Intervention;Learning;Link;Malignant Neoplasms;Measurement;Measures;Medical Oncology;Melanoma;Melanoma patient;Mental Depression;Mentors;Mentorship;Methods;mid-career faculty;mobile computing;neoplasm immunotherapy;Oral;Organ;Outcome Measure;Outcomes Research;Pathogenesis;Pathway interactions;Patient Outcomes Assessments;Patients;Phenotype;Physician Executives;Play;Population;practice setting;Prevention;professor;prospective;Prospective cohort;Prospective Studies;Prospective, cohort study;Quality of life;Recommendation;Reporting;Research;Resected;Rheumatology;Risk;Role;Secondary to;Severities;Single Nucleotide Polymorphism;Sleep disturbances;social;Solid;Solid Neoplasm;Specific qualifier value;statistics;surgical risk;Symptom Burden;Symptoms;System;T-Lymphocyte;Technology Assessment;Testing;Therapeutic;Therapy trial;Time;Toxic effect;Training;Translational Research;tumor immunology;Writing

PROJECT_TITLE: Immune-Related Adverse Events in Melanoma Patients Receiving Adjuvant Immune Checkpoint Inhibitor Therapy

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Chronic placental inflammation (CPI) is an important complication of pregnancy that has negative effects on child health, but little is known about its cause. This work will help us to understand whether viruses cause CPI, and that in turn may help us develop ways to prevent or treat this problem in pregnant women.

PI_NAMEs: ERNST, LINDA M;WYLIE, KRISTINE M. (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Acute;adverse pregnancy outcome;Affect;amniotic cavity;Anti-viral Response;Area;Bacterial Infections;Biological;Biological Assay;Biological Markers;biomarker development;Birth;Blood;Blood specimen;Child Health;Chronic;Clinical;cohort;Cytomegalovirus;Data;design;Detection;Development;Diagnostic tests;Etiology;Event;experimental study;Fetal Growth Retardation;Financial cost;Future;Gene Expression Profile;Gene Expression Regulation;Genomics;Growth;Herpesviridae;High Risk Woman;High-Throughput Nucleotide Sequencing;Immune response;Immunohistochemistry;improved;Inflammation;Inflammatory;Inflammatory Response;Influenza A virus;innovation;intraamniotic infection;Investigation;Lesion;Methods;Morbidity - disease rate;mortality risk;Neonatal;Nucleic Acids;Outcome;pathogenic virus;Pathway interactions;Patients;perinatal health;Placenta;Positioning Attribute;predictive test;Pregnancy;Pregnancy Complications;Pregnancy Outcome;Pregnant Women;Premature Birth;prevent;Process;Public Health;racial diversity;Reaction;Research;Resources;response;Sampling;Signal Transduction;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;Transcript;transcriptome sequencing;Umbilical Cord Blood;United States;Up-Regulation;Vasculitis;Vertebrate Viruses;Viral;viral detection;Viral Genes;Viral Genome;Viral Pathogenesis;Virus;Virus Diseases;virus identification;virus testing;Woman;Work

PROJECT_TITLE: Viral pathogenesis of chronic inflammatory lesions of the placenta

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]