ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition;Precision Medicine;Prevention

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE The landmark PREDIMED trial has demonstrated that Mediterranean dietary interventions significantly reduced the risk of major cardiovascular disease (CVD) events by approximately 30%, compared to a control diet. The goal of this competing renewal is to examine the effects of the Mediterranean dietary interventions on changes in urinary levels of metabolites and develop a multi-fluid (urine and plasma) multi-metabolite signature that significantly predicts future risk of CVD. The study has the potential to discover novel pathways through which diet influences CVD risk and facilitate the precision nutrition research agenda outlined in the 2020-2030 Strategic Plan for NIH Nutrition Research.

PI_NAMEs: HU, FRANK B (contact);LAMUELA-RAVENTÓS, ROSA ;MARTINEZ GONZALEZ, MIGUEL A.

PROGRAM_OFFICER_NAME: WOLZ, MICHAEL

PROJECT_TERMS: Acute myocardial infarction;Adherence;Biological Markers;Body Fluids;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;Cessation of life;Chickens;Chronic Disease;cohort;Consumption;Data;Data Analytics;Data Reporting;design;Diet;dietary;Dietary Assessment;dietary control;Dietary intake;Dietary Intervention;Dietary Practices;Disease Outcome;Event;evidence base;Fabaceae;Fasting;Fishes;Food;Food Patterns;fruits and vegetables;Future;Goals;Grant;Heart failure;improved;Individual;Intake;Intervention;Intervention Trial;Knowledge;Liquid substance;Measurement;Measures;Mediating;Mediterranean Diet;Metabolic;metabolome;metabolomics;multidimensional data;multidisciplinary;Myocardial Infarction;novel;Nutrition Policy;Nutritional;Nutritional Study;Nuts;Olive oil preparation;Paper;Participant;Pathway interactions;Patient Self-Report;Pattern;Plasma;population based;post intervention;precision nutrition;predictive marker;Prevention;Primary Prevention;Productivity;Publishing;Randomized;Recommendation;red wine;Research;research vision;Resources;response;Risk;risk prediction;Role;Sampling;Spottings;Strategic Planning;Stroke;Techniques;Technology;Testing;tool;United States National Institutes of Health;urinary;Urine;Work

PROJECT_TITLE: Mediterranean diet, Metabolites, and Cardiovascular Disease

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PI_NAMEs: KURAOKA, MASAYUKI  (contact)

PROJECT_TERMS: age group;Antibodies;antigen binding;Antigens;Avidity;B cell repertoire;B-Cell Antigen Receptor;B-Lymphocytes;Biological Assay;Cells;Cloning;Communication;cross reactivity;Data;data sharing;design;experience;Foundations;Generations;Genes;Genotype;Goals;Human;Immune response;Immunoglobulin G;Infection;Influenza;influenza infection;Influenza vaccination;Knowledge;Macaca mulatta;member;Memory B-Lymphocyte;Mus;nonhuman primate;Phenotype;Procedures;Program Research Project Grants;programs;repository;Research;Research Support;response;Role;Sampling;Secure;Specificity;Standardization;Structure;success;System;vaccination strategy;vaccine development;Vaccines

PROJECT_TITLE: Core D: Bmem Analysis Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: TAMPA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative The overall goal of this training program is to train the next generation of surgeon-scientists, who have the knowledge, skillsets and motivation to perform translationally relevant and meaningful research that will lead to significant improvements in patient outcomes. We have the infrastructure, resources, expertise and motivation to provide our trainees with advanced and individualized research training in a vibrant scientific environment. We believe that our training program will ultimately provide the society with much needed surgeon-scientists, who will be at the forefront of clinical practice in the future.

PI_NAMEs: KUO, PAUL C;MAJETSCHAK, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TITLE: Surgeon-Scientist Research Training in Injury Pathobiology and Outcomes In Critical Illness


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Diabetes;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Diabetic cardiomyopathy is strongly associated with the development of mitochondrial dysfunction and the effective elimination of damaged mitochondria is crucial to limit the progression of diabetic cardiomyopathy. Using patient-specific human induced pluripotent stem cells and novel transgenic mouse model, this research proposal aims to delineate novel molecular mechanisms that regulate mitochondrial clearance during diabetic conditions and contribute to discovery of therapeutic intervention that could prevent diabetic cardiomyopathy.

PI_NAMEs: ONG, SANG GING  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Address;Affect;Area;Autophagocytosis;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Cause of Death;Cell Death;Cell Line;Cell model;Cells;Clinical;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Coronary Arteriosclerosis;Cues;Data;db/db mouse;Degradation Pathway;Development;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;Diabetic mouse;diabetic patient;Disease;druggable target;Endosomes;Ensure;Excision;Exhibits;Exposure to;FRAP1 gene;Functional disorder;Future;Generations;Genes;Genetic;Genome;Goals;Guanosine Triphosphate Phosphohydrolases;Heart;Heart failure;High Fat Diet;Human;human induced pluripotent stem cells;human model;Hyperglycemia;Hypertension;Impairment;in vivo;induced pluripotent stem cell;innovation;Knock-out;Knockout Mice;late endosome;Link;Lysosomes;Mediating;Methods;Mitochondria;mitochondrial autophagy;mitochondrial dysfunction;Molecular;mortality;mouse model;Myocardial dysfunction;Non-Insulin-Dependent Diabetes Mellitus;novel;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phenotype;phosphatidylinositol 3-phosphate;Phosphorylation;PIK3CG gene;Predisposition;prevent;Process;protective pathway;Quality Control;rab GTP-Binding Proteins;Reactive Oxygen Species;Reagent;Reporting;Research;Research Design;Research Personnel;Research Proposals;response;Rodent;Role;Signal Transduction;Stress;Syndrome;System;Therapeutic Intervention;Transgenic Mice;Transgenic Organisms;Translating;Type 2 diabetic

PROJECT_TITLE: Rab GTPases-mediated mitochondrial clearance in diabetic cardiomyopathy

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pediatric;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: MOODY, MICHAEL ANTHONY (contact)

PROJECT_TERMS: Address;Adult;Affect;Age;Antibodies;Antibody Response;Antigenic Variation;Antigens;arm;B cell repertoire;B-Lymphocytes;Back;Cells;Child;cohort;Collaborations;Contralateral;design;Development;Epitope Mapping;Epitopes;Evolution;experimental study;Exposure to;flu;global health;Goals;Grant;Hemagglutinin;high risk infant;Human;Immunity;Immunization;Immunize;Immunologics;Immunology;imprint;Individual;infancy;Infant;Infection;Influenza;Influenza B Virus;influenza infection;Influenza prevention;Influenza vaccination;influenza virus strain;influenza virus vaccine;late life;Learning;Life;Location;Macaca mulatta;Memory B-Lymphocyte;Methods;Monoclonal Antibodies;Neuraminidase;neutralizing antibody;nonhuman primate;Outcome;Pattern;Persons;phrases;Population;Prevention strategy;Publishing;Recommendation;recruit;respiratory challenge;response;Role;Route;Sampling;Seasons;Series;Serology;Serum;Site;Specificity;Structure;Structure of germinal center of lymph node;Teenagers;Testing;Time;trivalent influenza vaccine;Update;Vaccination;vaccine strategy;Vaccines;Work;young adult

PROJECT_TITLE: Project 1: Human and Non-human Primate Influenza B-cell Repertoires


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Damage to our genetic material is a threat to our survival and a driving force of many diseases. This proposal investigates how cells protect the stability of the genome. The generated knowledge will have direct implications to understand tumorigenesis and will help in the design of more effective anti-cancer therapies.

PI_NAMEs: SMOLKA, MARCUS  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Affect;cancer cell;cancer clinical trial;cancer predisposition;cancer therapy;Cell Cycle;Cell Survival;Cells;Clinical Trials;CRISPR screen;Cytoprotection;Defect;design;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Repair;driving force;fitness;genetic approach;Genetic Diseases;Genetic Materials;Genome;genome integrity;Genome Stability;Genomics;genotoxicity;Human Genetics;immunodeficiency;inhibitor;Knowledge;Laboratories;Link;Maintenance;Mammals;Maps;Mediating;Metabolism;Mutation;Neurologic;novel;Oncogenes;Pharmaceutical Preparations;phosphoproteomics;Phosphotransferases;PIK3CG gene;Predisposition;programs;Proliferating;Proteins;Proteomics;Regulation;replication stress;Research;Resistance;Role;Signal Transduction;single molecule;superresolution microscopy;Technology;therapeutically effective;tumorigenesis;Work;Yeasts

PROJECT_TITLE: Signaling Mechanisms in Genome Maintenance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Cancer immunotherapy and fecal microbiota transplantation (FMT) can augment natural immune response against several tumor types, but not all patients respond, thus it is important to understand the reasons behind this clinical observation in order to achieve better outcomes. We have observed, in mouse studies, that naturally occurring differences in the mitochondrial DNA can drastically alter gut microbial composition and immune responses against melanoma, both mediated by the mitochondrial generation of reactive oxygen species (mROS) in immune cells. We now propose to determine if this mitochondrial modulation of tumorigenicity is applicable to other cancers, the immune cell type responsible, the metabolic basis of the mitochondrial- microbiota interaction, and the importance of immune cell mROS in modulating the efficacy of FMT.

PI_NAMEs: WALLACE, DOUGLAS C (contact)

PROGRAM_OFFICER_NAME: KIM, YOUNG S

PROJECT_TERMS: Adoptive Cell Transfers;Agreement;anti-PD-1;anti-PD-L1;anti-PD-L1 therapy;anti-PD1 therapy;anti-tumor immune response;antioxidant enzyme;Antioxidants;antitumor effect;C57BL/6 Mouse;cancer immunotherapy;cancer risk;catalase;Cell Nucleus;cell type;Cells;Cellular immunotherapy;Cellular Structures;Cessation of life;Clinical;Clinical Services;Colon Carcinoma;congenic;Congenic Mice;Congenic Strain;epigenome;fatty acid oxidation;fecal microbiota;fecal transplantation;Gene Expression;gene function;Generations;Genotype;Growth;gut microbiota;Hematopoietic;Human;Human papillomavirus 16;Immune;Immune response;Immune system;immunoregulation;Immunotherapy;Impairment;In complete remission;Ligands;Link;Lung Adenocarcinoma;Malignant Neoplasms;MC38;Mediating;Medical center;Melanoma;Melanoma patient;Melanoma Tumor;Mesothelioma;Metabolic;metabolomics;Metastatic Melanoma;microbiota;Mitochondria;Mitochondrial DNA;mitochondrial genome;Mus;Outcome;Oxidative Phosphorylation;patient response;Patients;permissiveness;Phenotype;Positioning Attribute;PPBP gene;Production;programmed cell death ligand 1;Reactive Oxygen Species;receptor;Refractory;Regulation;Resistance;response;Risk;Severities;Testing;Tissues;Transgenes;tumor;Tumor Immunity;tumor progression;Tumorigenicity;Variant;Volatile Fatty Acids

PROJECT_TITLE: Anti-tumor immunity and intestinal microbiota are modulated by mitochondrial DNA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Neurons project extended axons that can reach a meter in length; these axons must be maintained in a functional state over a lifetime. One essential mechanism that maintains axonal health is autophagy, or `self-eating', the process by which cells turn over dysfunctional organelles and aggregated proteins. Defects in autophagy are sufficient to cause neurodegeneration in diseases such as ALS and Parkinson's disease. Here, we will investigate the molecular mechanisms regulating the dynamics of autophagy in the axon.

PI_NAMEs: HOLZBAUR, ERIKA L (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Ablation;Address;Aging;Autophagocytosis;Autophagosome;Axon;axonal degeneration;Axonal Transport;Back;Biochemical;biophysical techniques;Caenorhabditis elegans;cell type;Cells;Cellular biology;Complex;Computer Models;Cytoplasmic Protein;Defect;Degradation Pathway;Disease;Drosophila genus;dynactin;Dynein ATPase;Eating;Ensure;Genes;Health;Homeostasis;Human;Huntington Disease;Huntington gene;In Vitro;in vitro Assay;in vivo;Induced pluripotent stem cell derived human neuron;insight;Intracellular Transport;late endosome;Length;life span;live cell imaging;Lysosomes;Maintenance;meter;Microtubules;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Motor;mouse model;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuronal cell body;Neurons;novel therapeutic intervention;Organelles;Parkinson Disease;Pathway interactions;Patients;Play;presynaptic;Presynaptic Terminals;Process;protein aggregation;Proteomics;Recycling;retrograde transport;Role;Route;Site;Stress;stressor;superoxide dismutase 1;superresolution microscopy;Synapses;Therapeutic;uptake;Work

PROJECT_TITLE: Dynamics of Axonal Autophagy in Neurons

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


PI_NAMEs: KELSOE, GARNETT H (contact)

PROJECT_TERMS: Affinity;Antibodies;Antibody Affinity;Antibody Response;Antigen Receptors;Antigens;arms race;B cell repertoire;B-Lymphocytes;Biology;Bone Marrow;Cells;Collaborations;Contralateral;design;Distal;Evolution;experimental study;Gene Rearrangement;Genetic;Helper-Inducer T-Lymphocyte;Hemagglutinin;Herd Immunity;Immunity;Immunization;Immunize;Immunologic Memory;imprint;Infection;Influenza;Influenza Hemagglutinin;influenza infection;Influenza vaccination;influenza virus strain;influenzavirus;Ipsilateral;Label;Location;Lymphoid Tissue;Memory B-Lymphocyte;Minority;Mus;mutant;Mutate;Neuraminidase;nonhuman primate;novel vaccines;pathogen;Plasma Cells;Population;programs;Proliferating;Proteins;recruit;Research;response;Role;Seasons;Secondary Immunization;secondary infection;Secondary to;Serum;Site;Specificity;Structure;Structure of germinal center of lymph node;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Epitopes;Tamoxifen;Testing;Vaccination;vaccine development;Vaccines;Variant;Viral;Virus;Work

PROJECT_TITLE: Project 2: Affinity Maturation of the B-cell Repertoire


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cancer;Nanotechnology

ORG_CITY: BALTIMORE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The interface between nanotechnology, cancer biology, and oncology is a new frontier for scientific exploration and for the creation of new and improved diagnostic, prognostic, and therapeutic tools to detect, diagnose, treat, cure, and prevent cancer. This grant will support an integrated interdisciplinary predoctoral and postdoctoral training program in nanotechnology for cancer research.

PI_NAMEs: WIRTZ, DENIS  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: anti-cancer research;Nanotechnology;post-doctoral training;pre-doctoral;Training Programs

PROJECT_TITLE: T32: Predoctoral and Postdoctoral Training Program in Nanotechnology for Cancer Research

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: STONY BROOK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Narrative The events of September 11th, 2001 traumatized many of the men and women who aided in rescue and recovery operations at Ground Zero were exposed to an extraordinary array of stressful experiences. In 2014, we began the only cognitive monitoring study of World Trade Center responders and have since identified associations between WTC exposures and cognitive symptoms consistent with preclinical Alzheimer’s disease. In this renewal application, we propose to build on our existing research framework to examine the extent to which PTSD instigates changes in blood-based biomarkers indicative of an Alzheimer’s disease neuropathological cascade.

PI_NAMEs: CLOUSTON, SEAN  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Address;Age;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid;Apolipoproteins;biological adaptation to stress;Biological Assay;Blood;blood-based biomarker;care costs;Cause of Death;Cessation of life;Childhood;Chronic;Chronic Post Traumatic Stress Disorder;Climacteric;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive performance;cognitive reserve;cohort;comorbidity;cost;cost estimate;Craniocerebral Trauma;Data;design;Disease;Dust;Emotional;Encephalopathies;Event;experience;Exposure to;Family;Family member;Freezing;Friends;Functional disorder;Future;Genetic;Genetic Carriers;Glial Fibrillary Acidic Protein;Health;high risk;Holocaust survivor;Impaired cognition;Incidence;Individual;Inhalation;late life;Life Cycle Stages;lifetime risk;Light;Link;Liquid substance;Longitudinal Studies;Measures;Memory;men;middle age;mild cognitive impairment;Monitor;nanoparticulate;Nerve Degeneration;Nervous System Disorder;Neurobehavioral Manifestations;neurofilament;neuroinflammation;neuropathology;neurotoxic;Neurotoxins;novel;operation;Particulate Matter;Pathologic;Phosphorylation;physical symptom;Pilot Projects;Plasma;Population;Post-Traumatic Stress Disorders;pre-clinical;Prevention;Questionnaires;Recovery;Reporting;Research;Research Infrastructure;Research Personnel;resilience factor;response;Risk;Risk Factors;Sampling;senescence;Severities;Smoke;Societies;Stress;Stressful Event;stressor;Symptoms;tau Proteins;tau-1;Tauopathies;Thallium;Time;Trauma;United States National Institutes of Health;Urine;Veterans;Woman;Work;World Trade Center exposure;β-amyloid burden

PROJECT_TITLE: A Life Course Approach to Integrating Trauma and Cognitive Aging: A Cohort of 9/11 Responders

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This project will investigate the impact that estrogen receptor alpha plays in the mediation of prostatic fibrosis that contributes to benign prostatic hyperplasia (BPH) progression. A better understanding of how fibrosis within the prostate develops at a molecular level due to estrogen receptor involvement allows for the identification of novel biomarkers in earlier detection and therapeutic intervention for the aging male population.

PI_NAMEs: MILES, HANNAH  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: 5 Alpha-Reductase Inhibitor;Adrenergic alpha-Antagonists;Adult;Affect;Age;Aging;Agonist;androgen biosynthesis;Androgens;antagonist;Apoptotic;Automobile Driving;Benign Prostatic Hypertrophy;Binding;Biological;Biological Markers;biomarker panel;Bladder;Chromatography;Clinical;clinically relevant;Complex;Detection;Development;Diagnosis;Disease;Disease Progression;Early Diagnosis;ESR1 gene;Estrogen decline;Estrogen Receptor 2;Estrogen Receptors;Estrogen Therapy;estrogenic;Estrogens;Etiology;experimental study;Fibrosis;Financial Hardship;Functional disorder;Goals;Growth;Healthcare Industry;high throughput analysis;Hormones;Human;Image;improved;in vivo;insight;instrumentation;Investigation;Kidney Failure;Knowledge;Label;Ligands;Lower urinary tract;lower urinary tract symptoms;male;mass spectrometric imaging;Mass Spectrum Analysis;Mediation;medicine man;men;Methods;Modeling;Molecular;Monitor;Mus;novel;novel marker;Obstruction;Operative Surgical Procedures;Pathogenesis;patient population;Patients;Peptides;pharmacologic;Play;Population;precision medicine;prevent;Process;Proliferating;Prostate;Prostatic;Protein Analysis;protein expression;Proteins;Proteomics;Raloxifene;receptor;receptor binding;recurrent infection;reduce symptoms;Research;Resolution;Role;Running;Sampling;Selective Estrogen Receptor Modulators;Serum;Signal Pathway;Signal Transduction;Smooth Muscle;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;steroid hormone;Stratification;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;Translating;Treatment Efficacy;treatment strategy;urinary;Urinary Retention;Urination;Urine;urologic;Work

PROJECT_TITLE: The role of estrogen receptor alpha in prostatic fibrosis contributing to benign prostatic hyperplasia


ORG_CITY: WORCESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Atrial fibrillation is the most common heart rhythm disturbance in the world, significantly affects the lives of the afflicted by causing symptoms that range from palpitations and fatigue to stroke, congestive heart failure and death. Current treatment options are limited by poor efficacy and substantial toxicity. This proposal focuses on developing novel a gene therapy to prevent or reverse the damage that atrial fibrillation causes to the heart and thereby eliminate the ability of the heart to remain in atrial fibrillation.

PI_NAMEs: DONAHUE, J KEVIN (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: A kinase anchoring protein;Abbreviations;Ablation;Acceleration;Action Potentials;Address;Adverse event;Affect;Anti-Arrhythmia Agents;Atrial Fibrillation;Automobile Driving;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcineurin;Calcineurin inhibitor;Calcium;calmodulin-dependent protein kinase II;Calpain;Caring;CCL2 gene;Cessation of life;Chest Pain;Clinical;clinically relevant;Complication;Congestive Heart Failure;connexin 40;Connexin 43;Connexins;Cytomegalovirus;Data;Dependovirus;Developed Countries;Development;Dilated Cardiomyopathy;Disabling;Disease;Dominant-Negative Mutation;Dyspnea;effective therapy;EFRAC;EGF gene;Elements;Epidermal Growth Factor;extracellular;Fatigue;fibrosarcoma;FOSL2 gene;FOXO1A gene;Future;gene therapy;Gene Transfer;Genes;Genetic;genetic inhibitor;Guanosine Triphosphate Phosphohydrolases;HDAC4 gene;Health Care Costs;Heart;Heart Atrium;Heart failure;heart rhythm;Hospitalization;Individual;Intervention;Investigation;Left atrial structure;Left Ventricular Ejection Fraction;Left ventricular structure;Lightheadedness;MAP2K1 gene;MAPK1 gene;MAPK8 gene;Methods;Minor;Mitogen-Activated Protein Kinases;Mitogens;Molecular;Mutation;Myocardium;Names;Nodal;novel;nuclear factors of activated T-cells;Oncogenes;Osteosarcoma;p38 Mitogen Activated Protein Kinase;Paint;Palpitations;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phosphotransferases;Polymerase Chain Reaction;porcine model;Potassium Channel;Preclinical Testing;prevent;Probability;Procedures;promoter;Protein Kinase;Proteins;Public Health;Rattus;Recording of previous events;Recurrence;Refractory;Regimen;Ribosomal Protein S6 Kinase;Ribosomes;Risk;Role;Sarcoma;side effect;Signal Pathway;Signal Transduction;Sinus;Stroke;structural heart disease;success;Symptoms;Toxic effect;transcription factor;Transforming Growth Factors;Transgenes;Translating;Translations;Virion

PROJECT_TITLE: Calcium and MAPKinase Signaling and Structural Remodeling in Atrial Fibrillation

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


PI_NAMEs: SCHMIDT, AARON GREGORY (contact)

PROJECT_TERMS: Address;Affect;Affinity;Antibodies;Antigen-Antibody Complex;Antigens;arms race;B cell repertoire;B-Lymphocyte Epitopes;B-Lymphocytes;Binding Sites;Biochemical;Biological Assay;Biophysics;Birds;Catalytic Domain;Chimera organism;Coupling;Cysteine;Data;design;Development;Directed Molecular Evolution;Engineering;Epitopes;Escape Mutant;Evolution;exhaustion;Exposure to;Generations;Genes;Goals;Hemagglutinin;HIV;Homo;Human;human subject;Immune;Immune response;Immunity;Immunization;imprint;In Vitro;in vivo;Infection;Influenza;Influenza A Virus, H1N1 Subtype;Influenza Hemagglutinin;influenza virus vaccine;innovation;Island;Libraries;Macaca mulatta;Mammalian Cell;Massachusetts;Modification;Molecular;Monoclonal Antibodies;movie;Mus;Mutagens;Mutation;Neuraminidase;neutralizing antibody;next generation;novel;novel vaccines;Outcome;pathogen;Pattern;pre-pandemic;programs;Property;Reaction;receptor binding;Recombinant Proteins;Recombinants;Regimen;response;Role;scaffold;Site;Structure;Structure of germinal center of lymph node;Surface;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Vaccines;Variant;Viral;Viral Antibodies;viral fitness;viral resistance;viral RNA;Virus;Yeasts

PROJECT_TITLE: Project 3: Influenza Virus HA and NA Immunogen Design


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Genetics;Mental Health;Mental Illness;Pediatric;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project is a multi-level intergenerational study of the relationship between parental mental disorders and their children’s subsequent experiences of marriage, contraceptive use and childbearing. The results will greatly advance understanding of the individual, family and community factors that influence whether parental mental disorders in childhood have persistent consequences for the long-term family experiences of their children. It will provide the scientific evidence required to design and target more effective interventions to support parents to promote the long-term health and wellbeing of children.

PI_NAMEs: AXINN, WILLIAM G. (contact);SCOTT, KATE MARGARET

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Age;Archives;Behavior;Cellular Phone;Characteristics;Child;child bearing;Child Mental Disorders;Child Welfare;Childhood;Clinical;Communities;community-level factor;Contraceptive methods;Contraceptive Usage;Data;design;Diagnostic;Disease;Divorce;DNA;early childhood;Education;effective intervention;Event;experience;Family;Family Study;Fathers;General Population;Generations;Genetic;Genetic Predisposition to Disease;Genetic Research;Genetic study;Health;High Prevalence;Household;Income;Individual;Infrastructure;innovation;intergenerational;Internet;Interview;Investigation;Knowledge;late life;Link;Living Arrangement;Marriage;Measurement;Measures;Mediating;Mental disorders;Mental Health;Modeling;Mothers;National Institute of Child Health and Human Development;National Institute of Mental Health;Outcome;parental influence;parental role;Parents;Personal Satisfaction;Persons;Play;polygenic risk score;Population;Population Growth;Pregnancy;Process;prospective;Recording of previous events;Research;Research Design;Risk Taking;Role;Saliva;Sampling;Severities;sex;sexual risk taking;Sexually Transmitted Diseases;Shapes;Social Sciences;Structure;substance use;Surveys;Telephone Interviews;tool;transition to adulthood;unintended pregnancy;Variant;Work

PROJECT_TITLE: Intergenerational Influences on Marriage, Contraception and Childbearing

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


PI_NAMEs: HARRISON, STEPHEN COPLAN (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Affinity;Age;age group;animation;Antibodies;Antibody Affinity;Antigen-Antibody Complex;Antigens;Area;arms race;B cell repertoire;B-Lymphocytes;Binding;Cell Compartmentation;cohort;Collaborations;Compensation;Complex;Cryoelectron Microscopy;design;Directed Molecular Evolution;Epitope Mapping;Epitopes;experience;Experimental Designs;experimental study;Foundations;future pandemic;Goals;Hemagglutinin;Herd Immunity;Human;human pathogen;Immune;Immune response;Immunity;Immunization;immunogenicity;Immunologics;Immunologist;imprint;In Vitro;in vitro Model;Infection;Influenza;Influenza Hemagglutinin;influenza infection;Influenza vaccination;influenza virus strain;insight;Laboratories;Maps;Memory B-Lymphocyte;memory recognition;Modeling;Molecular;mouse model;movie;Mus;Mutation;Neuraminidase;new technology;nonhuman primate;novel vaccines;Outcome;pandemic virus;Plasmablast;programs;Reporting;Research;Resolution;response;Sampling;Serum;Specificity;structural biology;Structure;Surface;T-Lymphocyte Epitopes;tool;Vaccination;vaccine response;Vaccinee;Vaccines;Viral;Virus;Visualization;Work

PROJECT_TITLE: Project 4:  Structural Biology of Influenza Antibody-Antigen Interactions


NIH_SPENDING_CATS: Cancer;Dietary Supplements;Genetics;Lung;Lung Cancer;Nutrition;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (NARRATIVE) Despite improved screening efforts and therapeutic advancements over the past decade, lung cancer continues to be the leading cause of cancer-related deaths worldwide and the second most prevalent cancer type in the United States, presenting an ongoing medical challenge for which scientific investigation can translate into significant clinical benefit. Some cancers, including lung cancer, have been shown to be susceptible to a novel, oxidative-stress dependent form of cell death, termed ferroptosis, so enhancing ferroptosis may be an alternative therapeutic strategy to target tumors that are resistant to conventional therapy. Using cutting-edge, preclinical mouse models that closely mimic human lung cancer, this work will determine if induction of ferroptosis impedes tumor development and investigate how specific common cancer mutations protect against ferroptosis to promote tumor growth, with the goal of providing deeper insight into a novel mechanism of cell death that can be harnessed for future cancer therapies.

PI_NAMEs: WU, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Antioxidants;Automobile Driving;Buffers;cancer cell;Cancer Etiology;cancer therapy;cancer type;carcinogenesis;Cell Death;Cell Death Induction;Cell Line;Cell Respiration;Cell Survival;Cellular Membrane;Cellular Stress;Cessation of life;Chemicals;chemotherapy;Chemotherapy and/or radiation;Clinical;Clinical Research;Coenzyme Q10;conventional therapy;cost;Data;Development;dietary antioxidant;Disease;Disease Progression;Enzymes;experimental study;Fatty Acids;Fellowship;Future;gain of function;Genes;Genetic;genetic manipulation;Genetic Transcription;Genetically Engineered Mouse;Glutathione;Goals;Growth;Homeostasis;Human;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;insight;interest;Investigation;Iron;iron metabolism;Kinetics;Knowledge;Lipid Peroxidation;Lipid Peroxides;Lipids;Literature;loss of function;Lung Adenocarcinoma;lung cancer cell;macromolecule;Magnetic Resonance Imaging;Malignant neoplasm of lung;Malignant Neoplasms;Medical;Membrane;Metabolic;Metabolism;metabolomics;Modeling;Molecular;Monitor;mouse model;mutant;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;novel;Output;oxidation;Oxidation-Reduction;oxidative damage;Oxidative Stress;Pathway interactions;peroxidation;Phosphotransferases;Play;Polyunsaturated Fatty Acids;pre-clinical;Pre-Clinical Model;preclinical study;Predisposition;Production;Prognosis;programs;Proliferating;public health relevance;Publishing;Reactive Oxygen Species;Regulation;Reporting;Resistance;response;Response Elements;Role;Rupture;screening;sensor;Signal Transduction;STK11 gene;Study models;Testing;tetrahydrobiopterin;Therapeutic;therapeutic biomarker;therapeutic target;transcription factor;transcriptomics;Translating;tumor;Tumor Burden;tumor growth;tumor progression;Tumor Promotion;tumorigenesis;United States;Work

PROJECT_TITLE: Dissecting the role of redox homeostasis and ferroptosis in lung cancer


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Dissemination and Implementation Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care

PHR: PROJECT NARRATIVE Timely management of dementia remains a challenge for primary care providers despite their central role in the care of patients with dementia. The goal of this proposal is to adapt and implement a practical intervention to facilitate high quality, comprehensive post-diagnosis care for dementia in traditional primary care settings. The proposal will support the career development of Dr. Halima Amjad who aims to develop practical patient- and clinician-centered strategies to improve the care of older adults with dementia.

PI_NAMEs: AMJAD, HALIMA  (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: acceptability and feasibility;Address;Advisory Committees;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;American;Assessment tool;Attitude;Award;Awareness;Behavioral Symptoms;care delivery;care outcomes;career;career development;Caregivers;caregiving;Caring;Categories;Clinic;Clinical;clinical care;clinical investigation;Clinical Investigator;clinical practice;Clinical Practice Guideline;Clinical Trials;Code;Cognition;cognitive testing;Community Physician;comorbidity;Complex;Computerized Medical Record;Dementia;dementia burden;dementia care;design;Development;Development Plans;Diagnosis;Disease;Education;effective intervention;Effectiveness of Interventions;Ensure;Environment;epidemiology study;Evaluation;Event;evidence base;experience;Family;Family Caregiver;Future;Geriatrics;Goals;Guidelines;Health;Health system;implementation barriers;implementation science;implementation strategy;Improve Access;improved;Incentives;Intervention;intervention delivery;Interview;Knowledge;Lead;Link;Maryland;Medical;medical schools;Medicare;Medicine;member;Mentorship;Methods;Modeling;multidisciplinary;Neurology;Nurses;older adult;Patient Care;patient oriented research;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Population;pragmatic implementation;pragmatic trial;preference;Prevention;Primary Care;primary care clinic;primary care practice;primary care provider;primary care setting;professor;Psychiatry;Quality of Care;Randomized, Controlled Trials;Recommendation;Reimbursement Mechanisms;Research;Research Methodology;Research Personnel;Research Support;Resources;response;Role;Safety;Services;Shapes;Site;skills;Social Workers;stakeholder perspectives;Structure;support tools;Surveys;System;Testing;therapy development;Time;Time Management;tool;Training;Translating;Translations;Universities;uptake;Visit

PROJECT_TITLE: Improving Post-Diagnosis Dementia Care in Primary Care

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Acute kidney injury (AKI) leads to acute cardiac dysfunction, known as cardiorenal syndrome type 3 (CRS3), which is associated with increased mortality and has no specific therapy. Our overall hypothesis is that AKI deleteriously affects normal energy metabolism and that the deficiency of metabolites necessary to maintain cardiac energy production is the underlying mechanism behind cardiac dysfunction after AKI. Completion of the Aims of this proposal will identify readily available therapies to improve cardiac function after AKI.

PI_NAMEs: FAUBEL, SARAH G (contact)

PROJECT_TERMS: Acetyl Coenzyme A;Acute;Acute Renal Failure with Renal Papillary Necrosis;aerobic glycolysis;Affect;Amino Acids;Antioxidants;Basic Science;Cardiac;Cardiorenal syndrome;Characteristics;Citric Acid Cycle;Clinical;clinically relevant;Consumption;Data;Dialysis patients;Dialysis procedure;Distant;Echocardiography;Electron Spin Resonance Spectroscopy;Energy Metabolism;epidemiologic data;Essential Amino Acids;Functional disorder;glucose metabolism;Glutamine;Glutathione;Glycolysis;Goals;Grant;Heart;Heart failure;heart function;Impairment;improved;in vivo;inhibitor;Injury;Injury to Kidney;Ischemia;Kidney;Link;Mediating;Mediator;Metabolic;Metabolism;Mitochondria;mortality;mouse model;Mus;Myocardial dysfunction;Nephrology;Nonesterified Fatty Acids;novel;Organ;Oxidative Phosphorylation;Pathway interactions;Patient Care;Patients;Phosphorylation;Plasma;prevent;Production;Publishing;Reactive Oxygen Species;Reporting;Resolution;Respiration;Spirometry;Stress;Superoxides;Supplementation;Syndrome;Systemic disease;Testing;Tissues;Up-Regulation;wasting

PROJECT_TITLE: Cardiac dysfunction after ischemic AKI in mice

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

PHR: Project Narrative People who inject drugs (PWID) are at risk for HIV, and pre-exposure prophylaxis (PrEP) could be an effective means of HIV prevention. PrEP uptake is low among PWID because of numerous barriers, one of which is stigma due to multiple intersecting characteristics such as drug use, race/ ethnicity, sexual identity, gender, poverty, HIV, and PrEP (i.e., intersectional stigma). This study aims to determine the relationship between intersectional stigma and PrEP willingness and uptake, as well as associations with other service use (i.e., healthcare, drug treatment, pharmacies, or syringe exchange programs) over time.

PI_NAMEs: WALTERS, SUZAN M (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Affect;AIDS prevention;Area;Awareness;Baseline Surveys;California;Cannabis;career;Characteristics;Colorado;Communities;Data;Data Collection;design;Development;Discrimination;Disease Outbreaks;Drug usage;Eligibility Determination;Ethics;Ethnic Origin;experience;Fentanyl;Future;Gender;Health;health care settings;Health Personnel;Healthcare;Heroin;HIV;HIV Infections;HIV Seronegativity;Individual;Injecting drug user;Intervention;marijuana legalization;marijuana use;Measures;Methodology;Modeling;Modification;multiple drug use;Needle-Exchange Programs;opioid user;Outcome;Parents;Pattern;Pharmacists;Pharmacotherapy;Pharmacy facility;Policies;Poverty;pre-exposure prophylaxis;Prejudice;prevent;Prevention approach;Prospective, cohort study;Race;Regimen;Research;Research Infrastructure;Research Project Grants;Reservations;residence;Risk;Sampling;Science;Services;sexual identity;skills;social;social stigma;social structure;sociodemographic variables;Stereotyping;Stigmatization;structural determinants;substance use;Syringes;Time;Training;Training Programs;Translating;United States;United States National Institutes of Health;uptake;willingness

PROJECT_TITLE: Intersectional Stigma Experiences, Pre-exposure Prophylaxis (PrEP), and Other Service Use Among People Who Inject Drugs

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: KINGSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Project Narrative Black adults experience disproportionate alcohol-related mortality and morbidity, and depression symptoms among Black adults are associated with more alcohol use and problems. With the ultimate goal of informing alcohol interventions for Black adults with depression, the proposed study aims to elucidate the momentary reciprocal associations between depression symptoms and alcohol use and problems among Black adults as well as the influence of racial stressors and symptoms in acute risk for alcohol use and problems among Black adults with varying severities of depression symptoms. This training and research represent a logical extension of the Applicant’s research program and will facilitate the acquisition and integration of knowledge on co- occurring depression and alcohol use and problems; micro-longitudinal methodology and data analytic techniques; minority health and health disparities; and grantsmanship and dissemination.

PI_NAMEs: THOMAS, EMMANUEL  (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: Acute;Address;Adult;Alcohol abuse;alcohol consequences;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol risk;alcohol use disorder;Alcohols;AODR mortality;Area;associated symptom;Black Populations;Black race;clinically significant;Communities;comorbid depression;Consumption;coping;Cross-Sectional Studies;Dangerousness;Data;Data Analytics;depressive symptoms;Discrimination;Ecological momentary assessment;Environment;Etiology;Event;experience;Feeling;Future;Goals;Grant;health disparity;high risk;Individual;Interview;Investigation;Knowledge;knowledge integration;Lead;Legal;Literature;Maintenance;Mental Depression;Methodology;Methods;minority health;minority health disparity;minority stress;Modeling;Morbidity - disease rate;Negative Reinforcements;Outcome;Participant;Perception;Population;Process;programs;protective factors;psychologic;Public Health;Race;recruit;Reporting;Research;research data dissemination;Resources;Risk Factors;Role;Sampling;Self Medication;Severities;skills;social;Stress;stressor;Surveys;Symptoms;Techniques;Testing;Time;Training

PROJECT_TITLE: Micro-Longitudinal Examination of the Association between Depression and Alcohol Misuse among Black Adults: Proximal Risk and Protective Factors


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE An inability to maintain genome integrity is associated with a loss of cellular homeostasis and several human diseases including cancer. Histone H2A variants are emerging as key components of chromatin that function in genome integrity that are often dysregulated in cancer. Our goal here is to identify how histone H2A variants collaborate with PARP1 and KDM5A to promote DNA repair and genome integrity pathways, including how their dysregulation may be targeted therapeutically using radiotherapy and PARPi.

PI_NAMEs: MILLER, KYLE M (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Binding;Biochemical;cancer cell;Cell Line;Cell model;Cells;Chromatin;Collaborations;Complement;Cytoplasm;Cytoprotection;cytotoxicity;Dangerousness;Data;Defect;Dependence;Deposition;DNA;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Sequence Alteration;Double Strand Break Repair;Ensure;Epigenetic Process;experimental study;Funding;gene regulatory network;gene repression;Genes;Genetic;Genetic Transcription;Genome;genome integrity;genome-wide;Genomic Instability;Goals;histone demethylase;Histone H2A;Histones;Homeostasis;homologous recombination;Human;human disease;Individual;innovation;insight;Knowledge;Lesion;macroH2A histone;Maintenance;Malignant Neoplasms;Mediating;Methods;Modification;Molecular;Molecular Chaperones;Molecular Structure;Mutation;Nucleosomes;Participant;Pathway interactions;Play;Poly(ADP-ribose) Polymerase Inhibitor;Post-Translational Modification Site;Post-Translational Protein Processing;Process;protective pathway;Proteins;Proteomics;Radiation;Radiation therapy;recombinational repair;recruit;repaired;Repression;Resistance;response;Role;Shapes;Signal Transduction;Site;System;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Uses;Transcriptional Regulation;treatment response;tumorigenesis;Variant;Work

PROJECT_TITLE: Shaping DNA Damage Response Networks Via Histone H2a Variants

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Neurosciences;Sexually Transmitted Infections;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: VETERINARY SCIENCES

PHR: Although acyclovir was approved by the FDA for use against herpes simplex infections back on March 29, 1982, latency has precluded curing herpes infections. Latency, which occurs in neurons, also poses a major challenge to the development of prophylactic or therapeutic vaccines. Despite many years of hard and clever work, the regulation of latency and reactivation still eludes us. This proposal tests an integrative model in which the efforts to silence the infecting virus by the infected cell are successfully counteracted by the virus in most cells. However, these efforts are not counteracted in the neurons to be latently infected, such that the persistence of the virus in the latent state is secured. Reactivation of latency would then occur when this silencing of the viral genomes is locally disrupted in the domains of the nuclei of the latently infected neuron where the latent genomes sit. This proposal tackles a major unaddressed gap in our knowledge of the pathobiology of herpes infections, thus opening a new path to explore towards the development of better therapeutics.

PI_NAMEs: SCHANG, LUIS M. (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acute;Acyclovir;Address;Anti-viral Agents;Architecture;Back;Binding;Biology;Cell Nucleus;Cells;Chromatin;chromatin protein;Chromatin Remodeling Factor;Clinical;Competence;Complex;curative treatments;Development;Disease;Encephalitis;Environment;Epidemiology;Epigenetic Process;epigenetic regulation;experimental study;Eye Infections;FDA approved;Gene Expression;Genes;Genetic Transcription;genital herpes;Genome;Herpes encephalitis;Herpes Simplex Infections;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;Histones;HIV;HIV Infections;Human Herpesvirus 2;human induced pluripotent stem cells;human pathogen;Immune response;Individual;Induced pluripotent stem cell derived human neuron;Keratoplasty;Knowledge;latent infection;Life;Location;Lytic;Lytic Phase;Maintenance;Maps;Medical;Modeling;Modification;neonatal infection;nerve stem cell;Neuroglia;Neurologic;Neurons;novel;Nuclear;Nucleosome Core Particle;Pathogenesis;Pathology;Peripheral Nervous System;permissiveness;Play;Post-Translational Protein Processing;Preventive vaccine;Process;promoter;Property;Prophylactic treatment;Proteins;Publishing;reactivation from latency;Recrudescences;recruit;Regulation;Rest;Risk;Risk Factors;Role;Secure;Simplexvirus;Stress;SWI/SNF Family Complex;Technology;Testing;Therapeutic;therapeutic vaccine;Trans-Activators;Transcription Coactivator;Transcriptional Regulation;transmission process;vaccine access;Variant;Viral;Viral Genome;Virus;Virus Latency;VP 16;Work;Zika Virus

PROJECT_TITLE: Chromatin dynamics in the regulation of herpes simplex virus 1 gene expression.

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: HADLEY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE Optimizing one’s behavior to obtain benefits while avoiding threats is critical for survival and is disrupted in many psychiatric disorders. In this project I will characterize the makeup and dynamics of brainstem noradrenergic circuits that coordinate behavioral responses for both achieving positive and avoiding negative outcomes. Results from these studies may help identify new treatment strategies for neuropsychiatric disorders including PTSD, addiction, and depression.

PI_NAMEs: RODBERG, ELLEN MARIE (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Adaptive Behaviors;addiction;Amygdaloid structure;Anxiety;Auditory;Auditory area;autism spectrum disorder;Behavior;Behavioral;behavioral response;Brain;Brain region;Brain Stem;Calcium;Cell Nucleus;Characteristics;cognitive process;Complex;Computational Technique;Cues;Data;Data Analyses;density;Detection;Disease;Dissociation;Electrophysiology (science);Environment;Evaluation;Extinction;extracellular;Food;Freezing;Fright;Genetic;Goals;Heterogeneity;Histology;Individual;Injury;Intervention;Label;large scale data;Learning;Light;locus ceruleus structure;maladaptive behavior;Maps;Mental Depression;Mental disorders;Mentorship;Motor Cortex;Negative Reinforcements;neural;neural network;neurochemistry;Neurons;neuropsychiatric disorder;noradrenergic;Norepinephrine;novel;novel therapeutic intervention;optogenetics;oral communication;Outcome;Population;Positive Reinforcements;Post-Traumatic Stress Disorders;Process;Property;Rattus;recruit;Research;Research Personnel;response;Rewards;Rodent;Role;Schizophrenia;Shock;Testing;Training;Ventral Tegmental Area;Viral;Work

PROJECT_TITLE: Locus coeruleus ensembles in active avoidance and reward seeking


NIH_SPENDING_CATS: Nutrition;Pediatric;Prevention

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Nutritional and dietary modifications are key components to the management of many pediatric chronic conditions yet are often difficult for youth and families to accomplish, causing significant morbidity and reduced life-expectancy. Clinical investigators with knowledge of behavioral, biomedical, nutritional, and clinical trials sciences are critically needed to develop empirically-tested prevention models and clinical interventions that improve dietary adherence, nutritional status, and long-term health and quality of life outcomes for youth. Graduates of this fellowship program will be national leaders who are team scientists and will have a significant impact on research in child behavior and nutrition and relevant health outcomes for many years to come.

PI_NAMEs: POWERS, SCOTT W;ZELLER, MARGARET H (contact)

PROGRAM_OFFICER_NAME: KAMARA, FANTA

PROJECT_TERMS: Child Behavior;Child Nutrition;Research Training

PROJECT_TITLE: Research Training in Child Behavior and Nutrition


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Chronic Pain;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Obesity;Pain Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: US adults have become increasingly sedentary – which greatly increases risk for cardiovascular disease and mortality - thus necessitating a need to elucidate simple, cost-effective methods to mitigate its harms. This study will use state of the art measures and analytic procedures to prospectively evaluate the purported benefits (improvement in cardiometabolic risk factors) and risks (vascular damage to the lower limbs, musculoskeletal pain) associated with standing and its pattern of accumulation in the highest risk group in the US - African Americans living in the stroke belt. Findings will improve our understanding of whether standing should be endorsed as an alternate activity to sedentary behavior and provide key foundational information critical to the success of future trials and ultimately public health guidelines.

PI_NAMEs: DIAZ, KEITH M (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Accelerometer;Address;Adult;Advocate;African American;African American population;American;Ancillary Study;Ankle;Back;Behavior;Blood Pressure;Blood Vessels;cardiometabolic risk;cardiometabolism;cardiovascular disorder risk;cardiovascular risk factor;Cholesterol;Cognitive;Cohort Studies;Communities;cost;cost effective;demographics;Detection;Developed Countries;Employee;Enrollment;Epidemic;Evaluation;evidence base;Exhibits;follow-up;Future;Glucose;Goals;Guidelines;Health;Health behavior;Health Benefit;Health Hazards;Health Policy;Health trends;high risk;high risk population;Home;improved;indexing;Individual;Infrastructure;interest;Intervention;Jackson Heart Study;Length;Lower Extremity;Measurement;Measures;Methods;Modification;mortality;mortality risk;Musculoskeletal;Musculoskeletal Pain;novel;Observational Study;Outcome;pain symptom;Participant;Pattern;Perception;Peripheral Vascular Diseases;Physical activity;physical conditioning;Population Group;Posture;Probability;Procedures;prospective;Prospective Studies;Protocols documentation;Public Health;Questionnaires;Research;Research Priority;Risk;Risk Factors;Risk Reduction;Schedule;Schools;sedentary;sedentary lifestyle;Smoking;social;standard measure;Strenuous Exercise;Stroke Belt;success;Techniques;Time;Triglycerides;Upper Extremity;Visit;waist circumference;Work;Workplace

PROJECT_TITLE: Evaluating Standing as a Health Behavior to Promote Cardiovascular Risk Reduction in African Americans

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


NIH_SPENDING_CATS: Biotechnology;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative  The directed movement of protein-associated membrane-bound compartments is a fundamental process required for the proper functioning of all eukaryotic cells, particularly those with long projections such as neurons that extend into and out of the spinal cord. Many neurodegenerative diseases including hereditary spastic paraplegias can be caused by defects in organelle transport. The proposed research will determine how membrane trafficking and homeostasis in the central nervous system are appropriately regulated, enhancing our fundamental understanding of these processes, which should facilitate the future identification of therapeutic targets for disease intervention.

PI_NAMEs: AUDHYA, ANJON  (contact)

PROJECT_TERMS: Address;Adverse effects;Affect;Age;Amyotrophic Lateral Sclerosis;Animals;Ataxia;Atrophic;Axon;axon guidance;axonal degeneration;axonopathy;Binding;Biochemical;Biochemistry;Birth;Brain;Cell Culture Techniques;Cells;Central Nervous System;Cerebral cortex;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;combat;confocal imaging;Corticospinal Tracts;CRISPR/Cas technology;Data;Defect;Dementia;Development;Disease;disease phenotype;Disease Progression;Distal;drug development;Drug Screening;early onset;Electromyography;electron tomography;Endosomes;Equilibrium;Escherichia coli;Etiology;Eukaryotic Cell;Exhibits;Filament;Foundations;fusion gene;Future;Gait;Gait abnormality;Genes;Genetic study;genome editing;gephyrin;Glutamates;Glycine;Goals;Hereditary Spastic Paraplegia;Histopathology;Homeostasis;human induced pluripotent stem cells;imaging approach;Immunohistochemistry;Impairment;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Inhibitory Synapse;innovation;Intermediate Filament Proteins;Intermediate Filaments;Intervention;kinematics;Late-Onset Disorder;Length;Lewy Bodies;Limb structure;Link;live cell imaging;Lower Extremity;Maintenance;Mediating;Membrane;Membrane Proteins;Microtubules;Modeling;Molecular;Motor;motor control;motor deficit;Movement;Muscle Weakness;Mutation;Nerve Degeneration;Nerve Fibers;Nervous System Disorder;Neurodegenerative Disorders;neurofilament;Neurofilament Proteins;Neuronal Dysfunction;neuronal excitability;Neurons;Neurotransmitters;novel therapeutics;Onset of illness;Organelles;overexpression;Paralysed;Parkinson Disease;Pathologic;Patients;Phenotype;Physiological;Physiology;Play;Positioning Attribute;Process;programs;Proteins;Proteomics;Rattus;receptor;Recombinant Proteins;reconstitution;Research;Resolution;Rodent;Rodent Model;Role;Scaffolding Protein;Signal Transduction;Solid;Somatotype;spasticity;spastin;Spinal Cord;Sprague-Dawley Rats;stem;stem cell model;Swelling;Synapses;Technology;Testing;Therapeutic;therapeutic target;Time;time interval;trafficking;Variant;Work

PROJECT_TITLE: Mechanisms Underlying Axonopathy in Hereditary Spastic Paraplegia

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN-M]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Genetics;Mental Health;Neurosciences;Pediatric;Prevention;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This project seeks to understand the role of genetic risk for cannabis use in predicting mental health, brain development, and cannabis use behavior in two adolescent populations. Aims 1 and 2 will identify the differences in behavior and brain development that arise from genetic variability, and Aim 3 will incorporate these measures into a prediction model for adolescent cannabis use. Results of this work will be of particular importance to public health and policy discussions surrounding the increased prevalence and legalization of cannabis use.

PI_NAMEs: SMITH, DIANA MUN YEE (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Behavior;Adolescent Development;Affect;Age;Age of Onset;Behavior;Behavioral;Behavioral Symptoms;Bipolar Disorder;Birth;Brain;Brain imaging;Cannabis;cannabis use behavior;Child;Childhood;Cognition;Cognitive;cognitive development;cohort;Cohort Studies;Complex;Data;Data Set;density;Development;Diffusion Magnetic Resonance Imaging;Doctor of Philosophy;early onset;Fathers;Genetic;Genetic Predisposition to Disease;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genomic locus;gray matter;hazard;Impairment;improved;Individual;Investigation;Label;Legal;longitudinal dataset;marijuana legalization;marijuana use;marijuana use disorder;Measures;Mental Health;Methods;Modeling;Mothers;Motivation;multimodality;neuroimaging;Onset of illness;Other Genetics;Participant;Patient Self-Report;Patients;Phenotype;polygenic risk score;Population;population based;Positioning Attribute;predictive modeling;Prevalence;Problem behavior;Process;psychogenetics;Psychoses;Public Health;Public Policy;Recreation;Recreational Drugs;Reporting;Research;Research Project Grants;Restriction Spectrum Imaging;Rewards;Role;Sampling;Sampling Studies;Statistical Models;Structure;substance use;Techniques;Testing;Time;United States;Variant;white matter;Work

PROJECT_TITLE: Genetic influence on behavior, brain development, and substance use in two large, longitudinal adolescent cohorts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Conserved cell signaling pathways such Hedgehog and Hippo pathways play essential roles in embryonic development and adult tissue homeostasis in species ranging from Drosophila to human. Deregulation of Hedgehog and Hippo pathway activities has been implicated in many types of human cancer. Understanding how Hedgehog and Hippo pathways are regulated and how these and other signaling pathways are integrated to control embryonic development and adult tissue homeostasis should not only provide novel insights into the etiology of human disease but may also provide new avenues for therapeutic treatment of cancer.

PI_NAMEs: JIANG, JIN  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Adult;adult stem cell;Basal cell carcinoma;Biochemistry;Biological Models;Biomedical Research;biophysical techniques;Cancer Biology;cancer therapy;Cell Communication;Cell Differentiation process;Cell Proliferation;Cell Survival;Cells;Cellular biology;Congenital Abnormality;Development;Developmental Biology;Developmental Process;Disease;Drosophila genus;Embryonic Development;Erinaceidae;Etiology;extracellular;Family;Fingers;Funding;G-Protein-Coupled Receptors;Genetic;Goals;Growth;Homeostasis;Human;human disease;in vivo;Injury;insight;Intestines;Intrinsic factor;Knowledge;Link;Malignant Neoplasms;Medulloblastoma;Modeling;Molecular;Natural regeneration;novel;organ growth;organ regeneration;Organ Size;Pathologic;Pathway interactions;Phosphorylation;Physiological;Play;Proliferating;receptor;Regenerative Medicine;Regulation;response to injury;Role;Signal Pathway;Signal Transduction;stem cell self renewal;stem cells;Therapeutic;tissue regeneration;Tissues;trafficking;transcription factor

PROJECT_TITLE: Cell signaling in development and regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Alterations in receptor tyrosine kinase (RTK) signaling cause a wide variety of diseases from bone diseases to defects in wound healing, to cancer. There are many types of RTK, including several subsets that are very poorly understood. Applying methods that have yielded valuable insight for other RTKs – and have identified new therapeutic approaches – our proposed research aims to understand how poorly understood RTKs (notably those regulated by WNTs) are regulated, adding important knowledge that we hope will reveal new therapeutic opportunities.

PI_NAMEs: LEMMON, MARK A (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Acylation;beta catenin;Binding;Bone Diseases;Complex;conformational conversion;Congenital Abnormality;Crystallography;Defect;Dependence;Dimerization;Disease;extracellular;Extracellular Structure;Human;human disease;insight;Insulin Receptor;kinase inhibitor;Knowledge;Ligand Binding;Ligands;Malignant Neoplasms;member;Membrane;Methods;Modeling;Molecular Conformation;Neurodevelopmental Disorder;novel therapeutic intervention;novel therapeutics;Phosphotransferases;Play;Property;Proteins;receptor;Receptor Protein-Tyrosine Kinases;Receptor Signaling;recruit;Regulation;Research;Resolution;Role;ROR1 gene;Signal Transduction;Signaling Molecule;small molecule;Subcellular structure;Testing;Therapeutic;therapeutic target;Tyrosine;Tyrosine Kinase Domain;WNT Signaling Pathway;wound healing

PROJECT_TITLE: Understanding Signaling by Non-Canonical Receptor Tyrosine Kinases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Cervical cancer mortality is expected to increase by 42% to 442,926 deaths worldwide by 2030 with 87% of cervical cancer deaths occurring in low and middle income countries. Patient navigation programs enhance access to care, promote self-efficacy, and sustain patient engagement with care, and have been shown to improve cancer outcomes, particularly among marginalized groups, rural populations, and impoverished communities. This research will contribute to the critical gap in the scientific literature describing the adaptation of cervical cancer patient navigation strategies to optimize programs across local contexts in low- and middle- income countries.

PI_NAMEs: DYKENS, JON ANDREW (contact);FAYE, ADAMA

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Address;Africa;Aftercare;Age;Area;cancer care;Cancer Control;Cancer Patient;Caring;cervical cancer prevention;Cervical Cancer Screening;Cessation of life;Chicago;Communication;Communities;community barrier;Community Health Aides;Continuity of Patient Care;cost;Country;Death Rate;Decision Making;Detection;Diagnosis;Early Diagnosis;early screening;Effectiveness;Effectiveness of Interventions;effectiveness/implementation hybrid;Emotional;Ensure;evidence base;experience;Exploration, Preparation, Implementation, and Sustainment;follow-up;Funding;Geography;Goals;Health Services Accessibility;Health system;Healthcare;Human Papilloma Virus-Related Malignant Neoplasm;implementation evaluation;implementation outcomes;implementation process;implementation science;improved;Incidence;Income;innovation;Intervention;Knowledge;Learning;Literature;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;marginalized population;Measures;Medical;men;Methods;Modeling;mortality;novel;Outcome;Participant;patient engagement;patient navigation;Penetrance;Phase;Pilot Projects;poor communities;pragmatic randomized trial;prevent;Prevention program;primary outcome;Process;programs;Public Health;Quality of Care;Quality of life;Reporting;Research;Research Methodology;Resources;Rural;rural area;Rural Population;Science;screening;screening services;secondary outcome;Secondary Prevention;Self Efficacy;Senegal;Services;social stigma;Social Work;success;System;United States National Institutes of Health;uptake;Variant;Vulnerable Populations;Woman;women's treatment;Work

PROJECT_TITLE: Adaptation and implementation of a patient navigation program for cervical cancer screening across contexts in Senegal

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: Principal Investigator: Chen, Lu Project Narrative This application proposes to use state-of-art genetic tools to explore the molecular mechanisms of retinoic acid- mediated homeostatic plasticity in the mouse hippocampal neurons. In identifying molecular players involved in different cellular events of synaptic RA signaling, this application will contribute to a better understanding of the synaptic and circuit underpinning of mental illness. PHS 398/2590 (Rev. 11/07) Page 1 Project Narrative

PI_NAMEs: CHEN, LU  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Address;Adult;Affect;AMPA Receptors;Animals;Behavioral;Binding;Brain-Derived Neurotrophic Factor;Cell Adhesion Molecules;Cognitive deficits;cognitive function;Coupled;Data;Development;Disease;Drug Targeting;environmental enrichment for laboratory animals;Event;Excitatory Synapse;Exhibits;flexibility;FMR1 gene;Fragile X Syndrome;Functional disorder;Funding Opportunities;Genetic;Genetic Transcription;Goals;Hippocampus;Human;Impairment;in vivo;Inherited;Inhibitory Synapse;insight;Intellectual functioning disability;Investigation;Laboratories;Learning;Link;Mediating;Mental disorders;Modeling;Molecular;mouse model;Mus;Mutation;Nature;Nervous System Disorder;neural circuit;Neurons;neuropsychiatric disorder;Neurosciences;new therapeutic target;novel;Patients;Phenotype;Physiological;postsynaptic;presynaptic;prevent;Principal Investigator;Process;Proteins;Regulation;Research;Research Project Grants;response;Retinoic Acid Receptor;retinoic acid receptor alpha;RNA Splicing;Role;Runaway;Sensory;Series;Shapes;Signal Pathway;Signal Transduction;Structure;Symptoms;Synapses;synaptic function;Synaptic plasticity;Testing;tool;trafficking;Translations;Tretinoin;Variant;Work

PROJECT_TITLE: A molecular investigation of retinoic acid-dependent homeostatic synaptic plasticity

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Anesthesiologists take care of patients in multiple clinical areas, including the operating room, the intensive care unit, the pain clinic and the preoperative clinic. In all of these settings, they have the opportunity to improve care and outcome of patients with a wide range of disorders. To continue leading the way in advancing our understanding of diverse diseases and developing better interventions in the perioperative period requires highly trained and skilled practitioners dedicated to research in anesthesia. Integrated training programs such as the one proposed are essential to produce these future leaders of our field.

PI_NAMEs: CLARK, DAVID J. (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TITLE: Research in Anesthesia Training Program (ReAP)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: The brain and gastrointestinal system mutually communicate through the vagus nerve to influence a wide range of behavioral and physiological functions, including emotional affect, cognition, feeding behavior, digestion, metabolism, and immune function. The proposed multi-PI research program applies novel translational approaches in a mouse model of early life stress (ELS) to reveal the transcriptional and connectional features of developing vagal sensory and motor neuronal subtypes, and to investigate enduring ELS-induced disturbances to vagal neural phenotypes and functions. Experimental outcomes will provide new insight into the role of vagal neurons and circuits in mediating the lifespan impact of ELS on behavior and physiology, with potential clinical implications for vagal nerve-targeted therapies to treat emotional, cognitive, and physiological disorders.

PI_NAMEs: LEVITT, PAT  (contact);RINAMAN, LINDA M

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Address;Adult;adverse childhood events;Affect;Afferent Neurons;Anatomy;Animal Model;Atlases;Behavior;Behavioral;Biological;biological adaptation to stress;Brain;brain shape;Brain Stem;Cardiovascular system;Cells;cholecystokinin 8;Chronic;Chronic Disease;Chronic stress;Clinical;Cognition;Cognitive;Communication;connectome;Coupled;Data;Development;differential expression;Digestion;Disease;disorder risk;Dorsal;Duodenum;early life adversity;early life stress;Emotional;Event;experience;experimental study;Exposure to;Feeding behaviors;Female;Fluorescence-Activated Cell Sorting;Fluorescent in Situ Hybridization;Foundations;functional adaptation;Functional disorder;Future;gastrointestinal;gastrointestinal system;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic Transcription;Genomics;gut dysbiosis;Health Status;high risk;Hormone secretion;Human;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Immune;immune function;Incidence;Inflammation;Inflammatory;Injections;innovation;insight;intestinal barrier;Investigation;Label;Libraries;Life;Life Experience;life span;Link;Long-Term Effects;male;Maps;Mediating;Mental Health;Messenger RNA;Metabolic;Metabolism;Modeling;Molecular;molecular phenotype;motility disorder;motivated behavior;Motor;motor control;motor disorder;Motor Neurons;mouse model;Mus;Nerve;neural;neural circuit;neurogenomics;Neurons;neurotransmission;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;Organ;Outcome;Pancreas;Pathway interactions;Peripheral;Phenotype;physical conditioning;Physiological;Physiology;Pilot Projects;Pituitary Gland;Pituitary Hormones;postnatal;pre-clinical;programs;Prosencephalon;Publishing;Reflex action;Reporter;Reporting;Research;Resolution;Resources;response;Risk;Rodent;Rodent Model;Role;Route;Sensory;sex;sex as a biological variable;Sex Differences;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Spinal;stimulus sensitivity;Stomach;Stress;Synapses;System;systemic inflammatory response;targeted treatment;Tissues;Tracer;transcriptome;transcriptomics;translational approach;treatment as usual;Vagus nerve structure;Viral;Viscera;Visceral;Work

PROJECT_TITLE: Impact of Early Life Experience on Vagal Neurons and Circuits

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: THE ACADEMY OF NATURAL SCIENCES OF PHILADELPHIA

PHR: Seeds to STEM proposes a bilingual culturally appropriate program that educates low- income Black and Latino children ages 3-5, their families, and preschool teachers about childhood nutrition, early STEM and literacy, and kindergarten readiness. It has an innovative focus on food access and serves populations in under-accredited early childhood care and learning centers, including home-based childcare providers. Seeds to STEM will be piloted in two major cities (Philadelphia, PA and Los Angeles, CA) and its three product deliverables will be distributed nationwide via a website and multiple professional dissemination networks.

PI_NAMEs: GENOVESI, JACQUELINE  (contact);JOVANOVIC, JENNIFER ;SONDERGELD, TONI A.

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: 5 year old;Accreditation;Address;Age;bilingualism;Black race;care providers;career networking;Caring;Child;Child Care;Childhood;Cities;Communities;Community Health;control trial;cost;Data;design;Development;Diet Habits;early childhood;Education;Educational Curriculum;Educational Models;Educational Status;Educational workshop;empowerment;Enrollment;Event;experience;Family;Feedback;Festival;Food;Food Access;food marketing;Grant;Health;Health Food;Health Resources;Health Services;Healthy Eating;Home;Hospitals;Hunger;improved;innovation;Instruction;interest;Journals;kindergarten;Knowledge;Latino;Learning;Letters;literacy;Los Angeles;Low income;lower income families;mathematical ability;meetings;Modeling;Museums;Neighborhoods;Nursery Schools;nutrition;Nutritional;Outcome;Parents;Participant;Peer Review;Philadelphia;Population;Poverty;Preschool Child;Program Appropriateness;programs;Public Health Schools;Publishing;Readiness;Research;Resources;School Teachers;Schools;Science;Science, Technology, Engineering and Mathematics Education;Self Efficacy;skills;Spanish/English;STEM curriculum;STEM program;Students;symposium;teacher;timeline;Universities;Update;urban area;urban children;web site;webinar;Work

PROJECT_TITLE: Seeds to STEM: Cultivating early Nutrition, Literacy, Numeracy, and STEM knowledge and skills in Teachers, 3-5 year olds, and Families through a Bilingual Asset-based curriculum in Two Major Cities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Pediatric;Rare Diseases;Tuberculosis

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative We propose a new TB-HIV Training Program (TBHTP) at the University of Nairobi and the Kenya Medical Research Institute in collaboration with the University of Washington to conduct training in TB-HIV co-infection research. To address the persistent problem of TB as the leading cause of death in people living with HIV infection, we developed a program to enhance training and local capacity in a high TB endemic country and train the next generation of leaders who will discover novel research and public health strategies to combat the TB epidemic.

PI_NAMEs: HAWN, THOMAS R (contact);NDUBA, VIDELIS ;OBIMBO, ELIZABETH MALECHE

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Bacillus;Biometry;Cause of Death;Childhood;co-infection;Collaborations;combat;Country;Coupled;doctoral student;Educational workshop;Epidemic;Epidemiology;Fellowship;Goals;Health;HIV;HIV Infections;HIV/TB;Infection prevention;interest;Kenya;Laboratories;Leprosy;Lung Diseases;Macrophage;Medical Research;Mentors;Mycobacterium tuberculosis;next generation;novel;online course;Organizational Affiliation;Pediatric Research;Persons;Pharmaceutical Preparations;Pharmacotherapy;programs;Public Health;Recording of previous events;Research;Research Institute;Research Personnel;Research Project Grants;Scientist;supportive environment;Training;training opportunity;Training Programs;Treatment Protocols;Tuberculosis;Universities;Vaccines;Washington;Work

PROJECT_TITLE: Tuberculosis & HIV Co-Infection Training Program in Kenya


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: UROLOGY

PHR: Narrative The proposed research is relevant to AHRQ’s mission “…to produce evidence to make health care safer, higher quality, more accessible, equitable, and affordable, and to work within the U.S. Department of Health and Human Services and with other partners to make sure that the evidence is understood and used.” It will employ a range of systems improvement approaches to generate evidence to improve patient safety, healthcare quality, and accessibility for transgender patients– thus making healthcare more equitable for this vulnerable patient population. Through an innovative partnership with the World Professional Association for Transgender Health (WPATH), the evidence generated through this research will be translated into a TRANS-SAFE certification program for healthcare organizations, ensuring that the evidence is understood and used at scale.

PI_NAMEs: ANGER, JENNIFER TASH (contact);CARD, ALAN JOSEPH;COHEN, TARA

PROGRAM_OFFICER_NAME: CHEW, EMILY

PROJECT_TITLE: The TRANS-SAFE Patient Safety Learning Lab: Systems Improvement for Psychosocial Safety in Transgender Care

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Bacteria contain a number of distinct RNA-based immune systems to protect them from attack by viruses and viruses have evolved ways to fight back and escape destruction by these immune systems. Our studies will define the molecular mechanisms that underlie these sophisticated bacterial immune systems as well as the viral systems that obstruct immunity. The information that we gain will expand our ability to exploit these natural systems as powerful research tools with far-reaching biotechnological and biomedical applications including diagnosis and treatment of human genetic disorders and combatting viruses and bacteria and that cause human disease and the spread of antibiotic resistance.

PI_NAMEs: TERNS, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Adaptive Immune System;Antibiotic Resistance;antiviral immunity;Back;Bacteria;Basic Science;Biochemical;Biotechnology;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Diagnosis;fighting;Gene Expression;Genetic;Genetic Diseases;Genome;genome editing;Human;human disease;Human Genetics;Immune;Immune mediated destruction;Immune system;Immunity;improved;innovation;insight;Knowledge;Mediating;Medical Research;Molecular;nuclease;Organism;pathogenic bacteria;pathogenic virus;Pathway interactions;programs;Proteins;Research;RNA;System;Technology;tool;Viral;Viral Physiology;Virus;Virus Diseases;Work

PROJECT_TITLE: CRISPR Capture, Destroy, and Counter-Attack Mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE The proposed research aims to assess the extent to which environmental and neighborhood-level exposures are related to time-to-pregnancy and infertility risk in Black women. This will be the first study focused on structural determinants of infertility in Black women. This work seeks to identify explanations for the racial disparity in infertility by focusing on risk factors of particular relevance to this group, identify opportunities for intervention, and promote a more equitable and inclusive framework for fertility research.

PI_NAMEs: WESSELINK, AMELIA KENT (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Address;Affect;aged;Air Pollution;Aircraft;American;Assisted Reproductive Technology;Black race;black women;Body mass index;Caring;Censuses;Classification;Clinic;cohort;Color;Communities;Conceptions;Couples;Data;Data Set;Disparity;Disparity population;early pregnancy;Economics;Education;Employment;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Environmental Health;environmental health disparity;Environmental Pollution;epidemiology study;Equity;experience;Exposure to;Factor Analysis;Female infertility;Fertility;Fertility Study;Government;Government Programs;Green space;hazard;Health;health disparity;health equity;high risk;Human;Income;indexing;Inequality;Inequity;Infertility;infertility treatment;Intention;Intervention;Investments;Life Cycle Stages;Link;Live Birth;Maps;Measures;Medical;meter;Methods;Modeling;Modernization;National Institute of Environmental Health Sciences;neighborhood disadvantage;Neighborhoods;Nitrogen Dioxide;Noise;novel;Occupations;Outcome;Ozone;Participant;Particulate Matter;Pathway interactions;Pattern;Planned Pregnancy;Policies;Pregnancy;Pregnancy Histories;Principal Component Analysis;Prospective, cohort study;Public Health;Race;racial disparity;racism;Recording of previous events;recruit;Reporting;Reproduction;reproductive;reproductive epidemiology;Reproductive Health;Research;research clinical testing;residential segregation;Risk;Risk Assessment;Risk Factors;Scholarship;segregation;Shapes;shift work;social;Societies;socioeconomic disadvantage;Socioeconomic Status;Statistical Methods;Stereotyping;structural determinants;study population;subfertility;success;theories;Time;time-to-pregnancy;Toxic Environmental Substances;Treatment outcome;trying to conceive;United States;virtual;White Women;Woman;Women's Health;Work

PROJECT_TITLE: An assessment of environmental and neighborhood-level risk factors for subfertility among Black women in the U.S.

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative: Cognitive impairment in Parkinson’s disease (PD) is extremely prevalent, affecting more than 80% of patients over the course of their disease, yet few treatment options exist for these disabling symptoms. Dysfunction in prefrontal cortex and subcortical areas likely contributes to PD cognitive impairment, however, very little is known about the activity of and connectivity of these two brain regions. Here, we propose to investigate cognitive networks in PD and to deliver low-frequency deep brain stimulation (DBS), a stimulation pattern with promising early results on cognition, while assessing the effects on a cognitively demanding inhibitory control task and prefrontal-subcortical electrophysiology.

PI_NAMEs: BENTLEY, JESSICA NICOLE (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Affect;Alabama;Anatomy;Area;awake;Award;Basal Ganglia;Behavior;Behavioral;Biological Markers;Biometry;BRAIN initiative;Brain region;career development;Chronic;Cognition;Cognition Disorders;Cognitive;cognitive function;cognitive impairment in Parkinson's;cognitive neuroscience;cognitive process;Cognitive Therapy;computational neuroscience;Coupling;Data;Deep Brain Stimulation;design;Development;Development Plans;disability;disabling symptom;Disease;effective therapy;Electrodes;Electrophysiology (science);Elements;Engineering;Ensure;flexibility;Fostering;Frequencies;Functional disorder;Funding;Future;Globus Pallidus;Goals;High Prevalence;Human;Impaired cognition;Impairment;improved;Individual;insight;Institution;interest;Knowledge;Left;Measures;Mental Depression;Mentors;Mentorship;Methods;mild cognitive impairment;Motor;Motor disability;motor symptom;Movement Disorders;multidisciplinary;Neurobehavioral Manifestations;neuromechanism;Neurons;neurophysiology;Neuropsychological Tests;neuroregulation;Neurosurgeon;neurosurgery;Newly Diagnosed;non-motor symptom;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Parkinson Disease;Patients;Pattern;Pharmaceutical Preparations;Phase;Physiological;Physiology;Play;Prefrontal Cortex;Prevalence;Public Health;Reapplication;Research;Resources;response;Role;signal processing;skills;Source;Symptoms;Task Performances;Techniques;Testing;Training;Transcranial magnetic stimulation;Universities;Work

PROJECT_TITLE: Investigating Inhibitory Control Networks in Parkinson's Disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Lung;Patient Safety;Precision Medicine;Sarcoidosis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Pulmonary sarcoidosis is a condition that ranges in severity from mild and self-limiting--meaning it goes away without chronic therapy--to life-threatening with end-stage irreversible organ damage. There are no reliable “tools” available to the clinician that provide useful information about a patient’s future risk of having progressive lung disease and without these tools, clinicians cannot make the best care decisions for their patients. This study was designed to address these unmet clinical needs by creating and testing these “tools” using blood test results and clinical information from several groups of people across the United State who have sarcoidosis.

PI_NAMEs: KOTH, LAURA L (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;African American;Age;Area Under Curve;Blood;Blood Proteins;Blood Tests;blood-based biomarker;Caring;chemokine;Chronic;Chronic Disease;Clinic;Clinical;Clinical Data;clinical development;Clinical Management;clinical practice;Clinical Practice Guideline;clinical predictive model;clinical predictors;Clinical Research;clinically relevant;cohort;Collaborations;Collection;Conceptions;Costs and Benefits;Cox Proportional Hazards Models;current pandemic;CXCL10 gene;CXCL11 gene;CXCL9 gene;Data;Data Analyses;Data Set;design;disease natural history;Disease Progression;Drops;Drug toxicity;Enrollment;Evaluation;Event;follow-up;Frequencies;Future;Goals;hazard;high risk;Immunosuppression;improved;Individual;Inflammation;Interferons;Intervention;Investigation;Laboratories;Life;longitudinal care;Longitudinal cohort;Lung;Lung Diseases;Measures;Medical;Messenger RNA;Modeling;Monitor;Motivation;novel;novel marker;Organ;Outcome;patient stratification;Patients;Performance;Persons;Physicians;Policies;predictive tools;Probability;prognostic;prognostic indicator;prognostic model;prognostic tool;prognostic value;prognostication;Provider;Publishing;pulmonary function;pulmonary function decline;Pulmonary Sarcoidosis;Qualifying;Race;Research;Research Design;Research Personnel;Resources;Risk;risk stratification;RNA;Sample Size;Sarcoidosis;Schedule;Serum;Serum Proteins;Severities;sex;success;systematic review;Test Result;Testing;Thoracic Radiography;Time;Tobacco;tool;Toxic effect;Training;training data;Transcript;Translating;Translations;United States;United States National Institutes of Health;Validation;Visit;Whole Blood;Work

PROJECT_TITLE: Development of Clinical Prediction Models for Pulmonary Outcomes in Sarcoidosis

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Social Determinants of Health;Suicide;Suicide Prevention;Telehealth

ORG_CITY: DURHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Suicidal ideation is strikingly common among people living with HIV worldwide, leading to higher burden of disease for both mental illness and HIV, poor HIV care engagement, increased transmission risk, and loss of life. In this K08 Career Development Award, Dr. Knettel proposes to develop and pilot test a 3-session, nurse- delivered telehealth counseling intervention to reduce suicidality and improve HIV care engagement among people living with HIV in Tanzania. By completing the proposed research and training plans, Dr. Knettel seeks to create a scalable intervention model to address a critical public health challenge, while gaining the needed skills to transition to independence as an academic researcher.

PI_NAMEs: KNETTEL, BRANDON A (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Administrator;Adult;Area;Award;Behavior Therapy;Biometry;burden of illness;Caring;Cause of Death;Cellular Phone;Characteristics;Clinic;Clinical;Clinical Trials;Cognitive Therapy;Collaborations;Communities;comorbidity;Continuity of Patient Care;cost effective;Counseling;COVID-19 pandemic;Data;Death Rate;Development;digital;Enrollment;Epidemic;Evaluation;experience;feasibility trial;Feedback;Feeling suicidal;Fellowship;Goals;Health;Health Services;Health Services Accessibility;Health Technology;HIV;HIV diagnosis;Hot Spot;Improve Access;improved;improved outcome;innovation;Inpatients;International;Internet;Intervention;intervention refinement;Interview;Investigational Therapies;K-Series Research Career Programs;Lead;Length;Licensing;Life;Life Expectancy;Medical center;meetings;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentors;Mentorship;mobile computing;Modeling;mortality;motivational enhancement therapy;National Institute of Mental Health;novel;novel strategies;Nurses;Office Nursing;Outcome;Participant;patient screening;Patients;Persons;pilot test;Population;professional atmosphere;professor;programs;Psychiatrist;Psychologist;Psychoses;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Reduce health disparities;reducing suicide;Research;Research Personnel;Resource-limited setting;response;Risk;Safety;Scientist;screening;Services;Site;skills;social stigma;standard of care;Structure;suicidal;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;Tanzania;Technology;technology intervention;telehealth;Telephone;Testing;therapy adherence;Training;Translational Research;transmission process;Treatment Efficacy;Universities;user centered design

PROJECT_TITLE: Telehealth to Reduce Suicidality and lmprove HIV Care Engagement in Tanzania

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Temporal lobe epilepsy is among the most prevalent and least therapeutically responsive variants of epilepsy. It is characterized by a set of debilitating symptoms, including seizures, cognitive problems, and emotional disturbances. These symptoms combine to impose a significant health burden, which could benefit from improved treatment options. This proposal focuses on determining how a hippocampal circuit, the dentate gyrus, may contribute to temporal lobe epilepsy and may be a viable therapeutic target to ameliorate the devastating symptoms of this disorder.

PI_NAMEs: TAKANO, HAJIME  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Affective;Aftercare;Anxiety;Area;Behavioral;Calcium;Code;Cognitive;cognitive function;comorbidity;Competence;Control Animal;debilitating symptom;dentate gyrus;designer receptors exclusively activated by designer drugs;Development;Disease;disease model;Emotional;emotional behavior;Emotional Disturbance;Emotions;Epilepsy;Exhibits;Experimental Models;experimental study;Foundations;Generations;granule cell;Health;Hippocampus;Human;Image;improved;in vivo;Intervention;Laboratories;Learning;Limbic System;Mediating;Memory;memory encoding;Moods;Mus;neuronal circuitry;Neurons;new therapeutic target;patch clamp;Pathologic;Pathology;Patients;Performance;Phenotype;Play;Population;Predisposition;Process;Property;recruit;Role;Seizures;Series;spatial memory;Symptoms;Techniques;Temporal Lobe Epilepsy;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy development;Time;Transgenic Organisms;Treatment Efficacy;Variant

PROJECT_TITLE: Normal and Pathological Function of the Dentate Gyrus

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Glial cells play critical roles in nervous system function, and their dysfunction can lead to a range of diseases from neurodevelopmental disorders to neurodegeneration and even cancer. Significant progress has been made in understanding neuron-glia interactions at synapses and axons, but how glia support neuronal cell bodies remains poorly defined due to the lack of genetic access to only those specific glial cells associated with the soma. By utilizing powerful, in vivo molecular-genetic approaches in Drosophila to study this universal phenomenon, our work will lay the foundation for mechanistically interrogating how glial interactions at neuronal cell bodies regulate CNS health and disease across species.

PI_NAMEs: COUTINHO-BUDD, JAEDA  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Animals;Appearance;Astrocytes;autocrine;Autocrine Communication;Axon;Behavior;Biochemistry;Brain-Derived Neurotrophic Factor;Cell Communication;Cell Survival;Cells;Cellular biology;Central Nervous System;Central Nervous System Diseases;Communication;Compensation;Data;Disease;Drosophila genus;Equilibrium;Exhibits;Extracellular Space;Family member;Foundations;Functional disorder;Ganglia;gene function;Genetic;genetic approach;genetic manipulation;glial cell development;Goals;Growth;Growth Factor;Health;Health system;Image;Immunoprecipitation;Impairment;in vivo;Individual;Infiltration;insight;Invaded;Ions;Length;Maintenance;Malignant Neoplasms;Measures;Metabolic;Microglia;Molecular;Molecular Biology;Molecular Genetics;Morphology;Nerve Degeneration;Nervous System;Nervous System Physiology;Neurodevelopmental Disorder;Neuroglia;neuron loss;neuronal cell body;Neurons;neurotrophic factor;Neurotrophin 3;Nutrient;Oligodendroglia;Organism;paracrine;Paracrine Communication;Peptide Hydrolases;Peripheral;Play;Process;Proteins;Proteomics;Protoplasmic Astrocyte;receptor;Role;Signal Transduction;Site;Specificity;Structure;Synapses;System;Techniques;tool;Work

PROJECT_TITLE: Mechanisms of Glial Interactions and Function at Neuronal Cell Bodies

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]