NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Older adults are prone to changes in sleep and cognition as they get older, and it has been proposed that sleep and circadian disturbances increase the risk of cognitive decline and dementia. Understanding subtle alterations in circadian rhythm timing in adults at risk of dementia and how such disturbances relate to cognitive functioning will identify potential predictive or treatment targets in the circadian timing system to mitigate age-related cognitive decline. I will investigate: 1) differences in circadian timing among older adults with intact cognition, older adults with subjective cognitive decline, and older adults with mild cognitive impairment; 2) associations between circadian rhythm timing and cognitive functioning in these groups; and 3) whether stress, a modifiable lifestyle factor associated with sleep disturbances and risk of cognitive impairment, moderates the associations between circadian rhythm timing and cognition.

PI_NAMEs: MCDOWELL, CELINA F (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: actigraphy;Adult;Age;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease risk;Attention;Behavior;Behavioral;Boston;career;Cause of Death;circadian;Circadian Dysregulation;Circadian Rhythms;Clinical Investigator;Cognition;Cognitive;cognitive ability;cognitive change;cognitive function;cognitive performance;Communities;Dementia;dementia risk;Detection;diaries;disability;Disease;Early Diagnosis;Early treatment;Evaluation;executive function;Exhibits;experience;Fellowship;flexibility;Functional impairment;General Hospitals;Home;Hospitals;Hour;human old age (65+);Impaired cognition;interest;Light;Massachusetts;Measures;Melatonin;Memory;mild cognitive impairment;modifiable lifestyle factors;Monitor;Nerve Degeneration;Neurodegenerative Disorders;Neuropsychological Tests;Neuropsychology;older adult;Outcome;Participant;Pathology;Patient Self-Report;perceived stress;Performance;Phase;Physiology;Population;pre-clinical;Predictive Factor;protective factors;Psyche structure;Research;Research Methodology;Rest;Risk;Risk Factors;saliva sample;Short-Term Memory;Signal Transduction;Sleep;Sleep Disorders;Sleep disturbances;sleep pattern;Stress;symptom treatment;System;Techniques;Testing;Time;Training;Universities;Woman;Work;Wrist

PROJECT_TITLE: Examining Sleep, Circadian Rhythms, and Cognitive Functioning in Older Adults at Risk of Dementia


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Despite great strides over the past decade, tools for genetic study and manipulation of Chlamydia spp. remain severely limited. This proposal will develop new and powerful genetic tools including tightly negatively regulated promoter expression systems, a Tn7-based single chromosomal insertion transgene system, and application of the latter to build new, smaller shuttle plasmids for transformation. Successful completion of these aims will enhance genetic studies in Chlamydia.

PI_NAMEs: MAURELLI, ANTHONY T (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Animals;Antibiotics;Applications Grants;Arabinose;Bacteria;Bacterial Physiology;Bacterial Sexually Transmitted Diseases;Blindness;Chlamydia;Chlamydia trachomatis;Chromosomal Insertion;Chromosomes;Communities;Complement;complement system;design;Development;Disease;Effectiveness;Escherichia coli;expression cloning;flexibility;Frequencies;Future;gene cloning;gene complementation;Gene Expression;Genes;Genetic;genetic analysis;Genetic Complementation Test;Genetic Enhancement;genetic manipulation;Genetic study;genital infection;Genome;Human;improved;Individual;innovation;interest;Lac Operon;Maintenance;Measures;mutant;Operon;overexpression;Paper;pathogenic bacteria;Phenotype;Plasmids;Population;prevent;promoter;Property;Publishing;Reporter Genes;Reporting;Repression;Research;Research Project Grants;Seminal;Site;sound;System;Testing;tool;Transgenes;Transposase;United States;Validation

PROJECT_TITLE: Advanced Genetic Tools for Studying Chlamydia

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF EDUCATION

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: SAN DIEGO

ORG_DEPT: PEDIATRICS

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The majority of children exposed to early adversity and trauma do not have access to sustainably delivered evidence-based mental health programs (EBPs), despite the growing prevalence of large-scale multiple-EBP implementation efforts aimed at increasing access to these services. The objective of this proposal is to develop and test a package of implementation strategies designed to promote the sustained delivery of child trauma EBPs by reducing provider turnover through targeting the associated mechanisms of provider burnout and organizational psychological safety climate. Findings will have a significant public health impact by informing efforts to increase the sustained availability of child trauma EBPs, thereby improving outcomes for children exposed to trauma.

PI_NAMEs: LIND, TERESA A. (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Address;Arkansas;burnout;California;Child;child health care service;Climate;Clinical;Community Mental Health Services;community partnership;community setting;cost;cost effectiveness;Data;design;Development;early life adversity;Early-life trauma;Effectiveness;evidence base;Evidence based practice;Evidence based program;experience;Exploration, Preparation, Implementation, and Sustainment;Exposure to;Foundations;Funding;Future;health care economics;health organization;Health Services Accessibility;Health system;implementation efforts;implementation framework;implementation science;implementation strategy;improved;improved outcome;Individual;Intervention;Literature;Measures;Mental Health;Mental Health Services;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methodology;Methods;Modeling;Multiple Trauma;National Institute of Mental Health;Needs Assessment;Occupational Health;organizational climate;Outcome;Outpatients;Perception;Phase;pilot test;Population;Prevalence;prevent;Program Sustainability;programs;Provider;provider factors;psychologic;Public Health;Randomized, Controlled Trials;Reporting;Research;research to practice;Resources;response;Risk;Risk Factors;Safety;Science;service providers;Services;skills;System;Techniques;Testing;theories;Training;Trauma;trauma exposure;traumatic stress;traumatized children;Wages;Work

PROJECT_TITLE: Improving Sustainment through Implementation Supports to Reduce Burnout in Therapists Delivering Child Trauma EBPs

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PUBLIC HEALTH RELEVANCE STATEMENT There remains an important need for the development of effective, rapid and safe methods for developing and refining new medical imaging technologies that can improve patient outcomes. Virtual imaging trials (VITs) hold great potential for this purpose but, currently, their effectiveness is generally limited by the use of image quality measures that do not quantify clinical utility for realistic diagnostic tasks. The proposed research will address this and thereby enable highly effective VITs that will accelerate new medical imaging technologies towards clinical use.

PI_NAMEs: ANASTASIO, MARK A (contact)

PROGRAM_OFFICER_NAME: SHABESTARI, BEHROUZ

PROJECT_TERMS: Acceleration;Address;Algorithms;Anatomy;Assessment tool;Case Study;Clinic;Clinical;Clinical Trials;clinically relevant;cohort;computerized tools;Computing Methodologies;Data;deep learning;denoising;Detection;Development;Diagnostic;Diagnostic Imaging;digital;Effectiveness;Ethics;Evaluation;experimental study;generative adversarial network;generative models;Human;ideal observer (Bayesian);Image;Image Analysis;image processing;imaging system;Imaging technology;improved;interest;Learning;Measurement;Measures;Medical Imaging;Methods;Modality;Modeling;Modernization;multimodal data;Needs Assessment;next generation;novel;open source;Patient-Focused Outcomes;Performance;Property;public health relevance;Research;restoration;simulation;Specific qualifier value;success;System;Task Performances;Technology;Time;Translations;ultra high resolution;Variant;virtual imaging

PROJECT_TITLE: Deep learning technologies for estimating the optimal task performance of medical imaging systems

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Infectious Diseases

ORG_CITY: BLOOMINGTON

ORG_DEPT: CHEMISTRY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The proposed research is relevant to public health because receptor crosstalk underlies the pathogenesis of many human diseases from autoimmune diseases to cancer, and because endocytosis is a vital cellular process. Understanding the functional role of endocytosis in receptor crosstalk will facilitate the development of new therapeutic approaches, such as immune adjuvants for cancer therapies and vaccines. Thus, the proposed research is relevant to the part of NIH’s mission that seeks to increase fundamental knowledge of biological processes that will lay the foundation for advances in disease diagnosis, treatment, and prevention.

PI_NAMEs: YU, YAN  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Autoimmune Diseases;Biological Process;cancer therapy;Cancer Vaccines;Cardiovascular Diseases;Cell membrane;Cell Nucleus;Cell Physiology;Cells;Chemicals;combinatorial;Communicable Diseases;Computer Models;COVID-19;Cues;Development;Disease;disease diagnosis;Endocytosis;endosome membrane;Endosomes;experimental study;extracellular;Feedback;Foundations;Functional disorder;Goals;human disease;Immunologic Adjuvants;Inflammatory Response;Knowledge;Length;Malignant Neoplasms;Mediating;Mission;Modeling;novel;novel strategies;novel therapeutic intervention;Organelles;Pathogenesis;Play;Prevention;Public Health;receptor;Receptor Cross-Talk;Reporting;Research;response;Role;Signal Transduction;Sorting;spatiotemporal;Specificity;Stimulus;United States National Institutes of Health

PROJECT_TITLE: How the endocytic network mediates specificity of cell signaling

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Pulmonary Hypertension;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE This proposed research is aimed at classifying novel subtypes of pulmonary arterial hypertension (PAH), by studying inflammation in the blood of patients (complex protein and genetic profiles) and using sophisticated computational methods (machine learning and systems-based network analysis) to find data patterns that would otherwise remain hidden. This research is relevant to public health as the burden of morbidity and mortality is high in PAH, and the current system used to classify patients does not inform treatment decisions. Our project has significant potential to improve public health, as it may yield a PAH classification scheme that sits closer to underlying pathobiology, provide a critical step toward identifying patients who will respond to specific therapies, help improve the design of forthcoming clinical trials, and create a framework for precision medicine.

PI_NAMEs: SWEATT, ANDREW JOHN (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Address;biobank;Bioinformatics;Biological;Biological Markers;Biology;biomarker discovery;Biometry;Blood;career;Cells;chemokine;Classification;Classification Scheme;Clinical;clinical phenotype;Clinical stratification;clinical subtypes;Clinical Trials;Clinical Trials Design;cohort;Collaborations;Complex;computerized tools;Computing Methodologies;Critical Care;cytokine;Data;data repository;design;Development;differential expression;Disease;Disease Progression;disorder risk;DNA Sequence Alteration;Evolution;experience;Functional disorder;Genes;Genetic;Growth Factor;Immune;Immune Targeting;Immunity;Immunology;Immunomodulators;improved;Inflammation;Inflammatory;innovation;insight;Investigation;Lead;Link;Lung;Machine Learning;Mentored Patient-Oriented Research Career Development Award;Mentors;Molecular;molecular phenotype;Mononuclear;Morbidity - disease rate;mortality;multidisciplinary;novel;Outcome;overexpression;Pathway Analysis;Pathway interactions;patient subsets;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Physicians;Plasma;precision medicine;prognostication;prospective;protein complex;Public Health;public repository;pulmonary arterial hypertension;Rare Diseases;Research;Research Personnel;response;Rest;Role;Sampling;Selection for Treatments;Severities;Severity of illness;Signal Pathway;System;Systemic disease;targeted treatment;Testing;Therapeutic;Therapeutically Targetable;Time;Toxin;Transcript;transcriptomic profiling;transcriptomics;Translating;treatment response;trend;Universities;Variant;Work

PROJECT_TITLE: Reclassifying Pulmonary Arterial Hypertension Into Immune Phenotypes Using Machine Learning

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Prevention;Rural Health

ORG_CITY: URBANA

ORG_NAME: CARLE FOUNDATION

PHR: Project Narrative The Carle Cancer Center NCORP provides access to National Cancer Institute (NCI) clinical trials to the residents of eastern Illinois and portions of Indiana. Expanding clinical research opportunities beyond the academic centers and into individual communities provides a broadly applicable evidence base that contributes to improved patient outcomes and a reduction in cancer disparities.

PI_NAMEs: ROWLAND, KENDRITH MARTIN (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Advanced Malignant Neoplasm;cancer care;Cancer Center;Cancer Control;cancer health disparity;cancer prevention;care delivery;Clinical Research;Clinical Trials;Communities;Community Clinical Oncology Program;community research;community setting;Data;data mining;Detection;Discipline;electronic data;Ensure;evidence base;experience;Family;Foundations;Funding;Goals;Health system;Healthcare;Healthcare Systems;Hospitals;Illinois;Image;improved;Indiana;Individual;Infrastructure;Institution;Integrated Health Care Systems;Investments;Medical center;medical specialties;member;Mentors;Mission;multidisciplinary;National Cancer Institute;novel;Oncology;Patient-Focused Outcomes;Population;Population Heterogeneity;Prevention;Primary Care;Process;programs;Provider;Quality of life;recruit;Research;Research Institute;Rural Population;screening;Training;Translational Research

PROJECT_TITLE: Carle Cancer Center NCI Community Oncology Research Program (NCORP)


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Hepatitis;Immunization;Infectious Diseases;Liver Disease;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_NAME: VACCINE RESEARCH INSTITUTE OF SAN DIEGO

PHR: Project Narrative Malaria is the world's most important lethal tropical parasitic disease (over 500,000 deaths each year) with an estimated 200 million clinical new illnesses each year. Natural P. falciparum infection requires muiltiple rounds over many years for partial immunity. Further, malaria control efforts are being impeded by the spread of multiple drug resistant malaria and the development of insecticide resistance by the anopheline mosquito vector. Therefore, an effective prophylactic vaccine is urgently needed to prevent further spread of these diseases.

PI_NAMEs: MILICH, DAVID R. (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Active Immunization;Adjuvant;Affinity;animal care;Anopheles Genus;Antibodies;Antigens;B-Lymphocyte Epitopes;B-Lymphocytes;Bacteria;Binding;Biological Models;Blood;C-terminal;Capsid Proteins;Carrier Proteins;CD4 Positive T Lymphocytes;Cessation of life;circumsporozoite;circumsporozoite protein;Clinic;Clinical;Complication;Contracts;Core Protein;cost;design;Developing Countries;Development;Disease;Dose;efficacy testing;Engineering;Epitopes;Formulation;Generations;Hepadnaviridae;Hepatitis;Hepatitis B Surface Antigens;Housing;Human;human monoclonal antibodies;human pathogen;Hybrids;Immune Sera;Immunity;Immunize;immunogenic;immunogenicity;Immunoglobulin G;Immunologics;In Vitro;in vivo;Individual;Infection;Insecticide Resistance;Knock-in;Knock-out;Knowledge;Laboratory Animals;Length;liver infection;Malaria;Malaria Vaccines;Measures;Minor;Modeling;Monitor;Mouse Strains;Multi-Drug Resistance;Mus;Nature;next generation;Oryctolagus cuniculus;Parasites;Parasitic Diseases;pathogen;Plasmodium falciparum;Plasmodium falciparum vaccine;prevent;Preventive vaccine;Production;protective efficacy;Proteins;Recombinants;screening;Selection Criteria;sex;Site;Specificity;Sporozoites;Sterility;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;Testing;timeline;Universities;vaccine candidate;vaccine efficacy;vaccine evaluation;vaccine platform;Vaccines;vector mosquito;Virus-like particle;Woodchuck

PROJECT_TITLE: Epitope-Based CSP Vaccines Optimized to Achieve Long-Term Sterile Immunity

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: TROY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

ORG_STATE: NY

PHR: Project Narrative Full exploration of the linkages between biology, biomedical engineering, and data science as well as translation of scientific evidence into clinical practice requires the bridging of disciplines in specific target areas that are central to multidisciplinary science. The Predoctoral Training Program for Alzheimer’s Disease at the Interface of Data Science, Engineering and biology at Rensselaer Polytechnic Institute (Rensselaer or RPI) will be dedicated to providing an integrated and multidisciplinary platform to train predoctoral students, with a focus on the quantitative linkages that define this interface and preparing trainees for creative and productive careers in ADRD research.

PI_NAMEs: WANG, CHUNYU  (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Alzheimer's Disease;Biology;Data Science;Engineering;pre-doctoral;Training Programs

PROJECT_TITLE: Predoctoral Training Program for Alzheimer’s Disease at the Interface of Data Science, Engineering and Biology


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pregnancy;Social Determinants of Health;Women's Health Research

ORG_CITY: COLLEGE PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative Twenty-four percent of women in the U.S. have an elective termination of pregnancy by the age 45. Mental symptoms and disorders are elevated among those having elective terminations relative to those not having elective terminations. This research seeks to understand mental health changes from before to after an elective termination and the role of the sociocultural context in mental health around such an experience.

PI_NAMEs: STEINBERG, JULIA RENEE (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Adult;Adverse event;Age;Anxiety;Attenuated;brief intervention;Buffers;Characteristics;Child;Clinic;clinical practice;Cognitive;Cohort Studies;coping;Coping Skills;Data Set;depressive symptoms;Disease;Emotions;Empirical Research;ethnic diversity;expectation;experience;Family;feasibility testing;Feeling suicidal;Florida;Future Generations;Geographic Locations;Geography;Goals;Individual;Iowa;Knowledge;Legal;life span;Low income;Maryland;Mediating;Mental Health;Mental health promotion;Methodology;Mothers;novel;Patients;perceived stress;Personal Satisfaction;Policies;post-traumatic symptoms;pregnancy health;Psyche structure;racial diversity;recruit;reduce symptoms;reproductive;Research;Role;social culture;social stigma;Social support;Stigmatization;Stress;Stress and Coping;Symptoms;Termination of pregnancy;Texas;theories;Time;unintended pregnancy;Variant;Woman

PROJECT_TITLE: Sociocultural context and mental health around an unintended pregnancy

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: The proposed University of Illinois Short-Term Research Training Program (SRTP) will provide first year medical students with a 10-week mentored research experience in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) mission areas including, kidney, urologic and hematologic diseases; digestive disease and nutrition; and diabetes, endocrinology and metabolic disease. The proposed program brings together an outstanding team of established and emerging mentors with expertise in basic/mechanistic, clinical/translational, and behavioral/community-based research spanning NIDDK mission areas. In addition to mentored research, students will participate in interactive structured curriculum focused on research methodology, responsible conduct of research, presentation skills, and career development.

PI_NAMEs: ALREFAI, WADDAH A.;LASH, JAMES P. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Achievement;Address;African American;Area;Behavioral;career;career development;Chicago;Clinical;cohort;college;Communication;Communities;community based research;Country;Diabetes Mellitus;Digestive System Disorders;Education;Educational Curriculum;Endocrinology;Enrollment;Event;experience;Exposure to;Fostering;Funding;Hematological Disease;Illinois;Infrastructure;innovation;Institution;Journals;Kidney Diseases;Latino;Learning;medical schools;Medical Students;Medicine;Mentors;Metabolic Diseases;metropolitan;Midwestern United States;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Newsletter;novel;nutrition;Outcome;peer;peer coaching;Physicians;Population;Program Evaluation;programs;recruit;Reproducibility;Research;Research Activity;research and development;Research Methodology;Research Support;Research Training;responsible research conduct;Scholars Program;Scientist;skills;social media;Social Network;Structure;Students;symposium;Training Programs;Universities;Urologic Diseases;web site;Work

PROJECT_TITLE: Short-Term Research Training Program in NIDDK Mission Areas

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Knowledge of host pathways regulating the control of inflammation may impact our understanding of susceptibility to infections (like HIV-1) and other inflammatory diseases and could lead to new approaches to prevention and treatment of these diseases. We hypothesize that variants in two inflammation-regulating genes may modify risk of HIV-1 infection. We propose to further define these relationships and explore the possibility of inflammation-related effects of these variants using data from seven existing cohorts and archived blood and mucosal samples.

PI_NAMEs: HLADIK, FLORIAN ;LINGAPPA, JAIRAM RAO (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Accounting;Africa;African;Archives;Autophagocytosis;base editing;Biological;Biological Specimen Banks;Blood;Blood Cells;CD8-Positive T-Lymphocytes;Cell Nucleus;cell type;Cells;chemokine;cohort;Colitis;Counseling;Cryopreservation;cytokine;Data;Diabetes Mellitus;Disease;Epidemiology;Equilibrium;ethnic diversity;Exhibits;Exposure to;female sex worker;Genes;Genetic;genetic variant;genital infection;Genitalia;Genome;genome editing;genomic data;Genotype;hazard;Heterosexuals;high risk;high risk men;Highly Active Antiretroviral Therapy;HIV;HIV risk;HIV-1;Homeostasis;Immune;immune activation;Immunoglobulin Domain;Immunologics;In Vitro;Individual;Infection;infection risk;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Interferons;Interleukin-2;Intervention;Knowledge;Link;Macrophage;Mediating;Medicine;Membrane;men who have sex with men;Molecular;monocyte;Mucous Membrane;Mus;Myeloid Cells;Natural Resistance;novel;novel strategies;nuclear factors of activated T-cells;Nuclear Translocation;Outcome;pandemic disease;pathogen;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Population;pre-exposure prophylaxis;Predisposition;prevent;Prevention approach;Production;protective allele;Public Health;Receptor Protein-Tyrosine Kinases;recruit;Regulation;Regulatory T-Lymphocyte;Reporting;Research Personnel;Resistance;Risk;risk variant;RNA Splicing;sample archive;Sampling;seroconversion;Single Nucleotide Polymorphism;Site;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Tissues;Toll-like receptors;trait;transcription factor;transcriptome;Tyrosine Kinase Receptor Inhibition;United States;Untranslated Regions;vaginal mucosa;Variant;Viral;Woman

PROJECT_TITLE: The push and pull of inflammation on HIV susceptibility: impact of host variation in CD101 and AXL

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: The innate immune system deploys various pattern-recognition receptors, including Toll-like receptors (TLRs), to detect the infection of pathogenic microbes and initiate protective responses. We recently discovered that specific short non-coding RNAs (sncRNAs) are abundantly accumulated upon activation of TLR pathways in macrophages and their extracellular vehicles (EVs). The goal of the proposed project is to characterize the expression profiles of infection-induced sncRNAs and to explore their function in stimulating TLRs, which will represent novel research efforts to clarify sncRNA-engaged pathway in the immune response and may support future exploration of biomarkers and efficacious therapeutic applications targeting the sncRNAs in microbe infection.

PI_NAMEs: KIRINO, YOHEI  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Bacteria;Biological Markers;Bovine Tuberculosis;Cell surface;cell type;Cells;chemokine;Communicable Diseases;cytokine;Data;Disease;Elements;Endosomes;extracellular;extracellular vesicles;Foundations;fungus;Future;Goals;Human;human disease;Immune;Immune response;Individual;Infection;Innate Immune Response;Innate Immune System;inorganic phosphate;insight;Invaded;Investigation;Knock-out;Knowledge;Ligands;Ligation;Lysosomes;Macrophage;Microbe;MicroRNAs;Molecular;monocyte;Mycobacterium tuberculosis;Nature;NF-kappa B;novel;Nucleic Acids;pathogen;pathogenic microbe;Pathway interactions;Patients;Pattern;Pattern recognition receptor;Periodicity;Plasma;Procedures;Production;Receptor Activation;Research;response;Ribosomal RNA;RNA;Sampling;Signal Transduction Pathway;Surface;Therapeutic;therapeutic target;Tissues;TLR7 gene;TLR8 gene;Toll-Like Receptor Pathway;Toll-like receptors;tool;transcription factor;Transcriptional Activation;transcriptome;transcriptome sequencing;Transfer RNA;Tuberculosis;Untranslated RNA;Virus

PROJECT_TITLE: Endogenous single-stranded RNA ligands for endosomal Toll-like receptors

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: GREENSBORO

ORG_NAME: NORTH CAROLINA AGRI & TECH ST UNIV

ORG_STATE: NC

PHR: PROJECT NARRATIVE Using mixed methods research designs, the proposed study will contribute to an understanding of how social media messaging, particularly that composed of photographs and body imagery, targeting Generation Z African American women, impacts their dietary and fitness habits. The findings will assist in creating targeted prevention programs regarding obesity and subsequent health issues. Current research involves very few African American women, and much of it relies on the use of qualitative, but not quantitative measures.

PI_NAMEs: SMITH, KALYNDA CHIVON (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Address;African American;African American Women;Appearance;Arabs;Behavior;Behavioral;black women;Body Image;Body mass index;Body measure procedure;Chronic Disease;Code;cohort;Control Groups;Correlation Studies;Cosmetic surgery;Data;Data Collection;Dedications;design;Diet;diet and exercise;Diet Habits;Diet Surveys;dietary;Eating;Eating Disorders;Ethnic Origin;Etiology;Exercise;experimental study;Exposure to;fitness;Gender;Generations;graduate student;Habits;Health;Health behavior;health management;Health Professional;Health Surveys;Healthy Eating;Heart Diseases;Image;Imagery;Incidence;innovation;Instagram;Interview;Label;Manuscripts;Measures;media use;Methods;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Participant;participant interview;Patient Self-Report;Persons;Phase;phenomenological models;physical conditioning;pilot test;Population;Prevention;Prevention program;programs;Protocols documentation;Psychology;Psychometrics;Psychosocial Factor;Questionnaires;Race;Randomized;Regulation;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Training;response;Sampling;self esteem;social media;Societies;Structure;student participation;Students;Technology;Time;Training;trend;undergraduate student;United States Food and Drug Administration;Weight maintenance regimen;Woman;Women's Group;Writing

PROJECT_TITLE: How Health and Weight Management Social Media Messages Targeting African American Women Impact Health Behaviors


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Genetic recombination is a fundamental process that all living cells use to repair DNA damage that occurs during DNA synthesis or from exogenous sources. It is also the method of choice for altering genomes to study how precise changes in gene function are associated with different disease states. Insights into the mechanisms that repair double-strand breaks will impact studies in all organisms, especially those that are used as model systems for studying human disease.

PI_NAMEs: ROTHSTEIN, RODNEY J. (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Appearance;assault;Biological;Biological Models;Biological Process;cancer cell;Cells;Cellular biology;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;design;Diploid Cells;Disease;disease model;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA replication fork;DNA-Directed DNA Polymerase;Double Strand Break Repair;endonuclease;Excision;Gamma Rays;gene function;gene product;gene replacement;Genes;Genetic;Genetic Recombination;Genome;Genomic Instability;Homologous Gene;Human;human disease;Immunoglobulin Switch Recombination;in vivo;insight;Lesion;Malignant Neoplasms;Measures;Messenger RNA;Methods;Molecular;Molecular Biology;Movement;mutant;Mutation;Organism;overexpression;oxidation;Process;Proteins;repaired;Role;Site;SMARCA3 gene;Source;System;Techniques;Time;Visualization;Yeasts

PROJECT_TITLE: Molecular Mechanisms Underlying Recombination at DNA Double-Strand Breaks and Stalled Replication Forks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: PROJECT NARRATIVE The wealth of multiple-omics datasets produced by the Cancer Genome Atlas and NCI’s Genome Data Analysis Network have set the stage to understand and predict health outcomes for cancer patients. Our proposal would contribute to the future GDAN to apply computational approaches that unite these data with the growing information contained in new single-cell datasets to provide key information about the types of cells that comprise a tumor and its microenvironment through the use of mRNA gene expression signatures. We will share new results of the GDAN through the TumorMap and Xena Browsers to support exploration of the data through collaborations with Analysis Working groups and work with the consortium to define state-of-the-art machine-learning methods to predict therapy response in new clinical trial datasets.

PI_NAMEs: BENZ, CHRISTOPHER ;STUART, JOSHUA MICHAEL (contact)

PROGRAM_OFFICER_NAME: YANG, LIMING

PROJECT_TERMS: Address;Atlases;Automobile Driving;Behavior;Cancer Patient;cancer therapy;Cell Extracts;cell type;Cells;Characteristics;Clinical;Clinical Protocols;Clinical Trials;Clinical Trials Network;Collaborations;Collection;Competence;Complex;computerized tools;Computing Methodologies;Data;Data Analyses;data exploration;Data Set;Evolution;Future;gene expression database;Gene Expression Profile;Genome;Genome Data Analysis Center;Genome Data Analysis Network;genomic data;Genomics;Glean;Goals;Health;Human;individual patient;innovation;Knowledge;Machine Learning;machine learning classifier;machine learning method;machine learning prediction;Maps;Messenger RNA;Mixed Neoplasm;Modality;Molecular;mRNA sequencing;Multiomic Data;multiple omics;neoplastic cell;novel;Outcome;Pathway Analysis;Pathway interactions;patient prognosis;patient response;Patient-Focused Outcomes;Patients;Pattern;Play;predicting response;Prediction of Response to Therapy;Predictive Value;pressure;prognostic of survival;prognostic value;Publications;Role;Sampling;single cell mRNA sequencing;Somatic Mutation;The Cancer Genome Atlas;Training;treatment arm;treatment response;tumor;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor Subtype;Visualization;Work;working group

PROJECT_TITLE: UCSC-Buck Genome Data Analysis Center for the Genomic Data Analysis Network v2.0


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: The proposed research is relevant to public health because a comprehensive understanding of the neural and cognitive basis of apathy will contribute directly to the development of neurobiologically-targeted treatments for apathy, thus alleviating the associated patient and caregiver's burden of this common issue across dementias.

PI_NAMEs: VANEGAS-ARROYAVE, NORA  (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: 3-Dimensional;Affect;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Animal Model;Anterior;Apple;Atrophic;Basal Ganglia;Behavior;Behavioral;Brain;Caregiver Burden;Caregivers;cingulate cortex;Cognitive;cognitive process;Computers;Corpus striatum structure;Decision Making;Deep Brain Stimulation;Dementia;Deterioration;Development;Dimensions;Disease;Dissociation;Dorsal;effective therapy;Electric Stimulation;Electrodes;Emotional;Enrollment;experience;experimental study;Focused Ultrasound;frontal lobe;Frontotemporal Dementia;functional MRI scan;Goals;human imaging;Hypersensitivity;information processing;Insula of Reil;Intervention;Knowledge;Lesion;Link;Literature;Location;Measures;Mediating;Mediator;motivated behavior;Motivation;motor control;motor deficit;Nerve Degeneration;neural;neural circuit;Neuroanatomy;Neurobiology;neuroimaging;neuropathology;neuropsychiatric symptom;neuropsychiatry;Neurosciences;new therapeutic target;Operative Surgical Procedures;Parkinson Disease;Participant;Patients;Performance;Pharmaceutical Preparations;Play;Population;Positive Valence;Postoperative Period;Prefrontal Cortex;Public Health;Quality of life;recruit;Research;Research Domain Criteria;Rewards;Risk;Role;routine care;Severities;STN stimulation;Structure;Structure of subthalamic nucleus;study population;Symptoms;Syndrome;systems research;Task Performances;Testing;Time;Ventral Striatum;Viral Vector;white matter;Work

PROJECT_TITLE: Investigating neuroanatomical underpinnings of apathy in ADRD through neuroimaging and electrical manipulation

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) are common and disabling psychiatric disorders, treatments for which have been hindered by their heterogeneity in clinical presentation and underlying mechanisms. This project investigates the heterogeneity of clinical symptoms, behavior, and brain function in OCD and MDD using hypothesis- and data-driven approaches. The overall goals of this work are to identify factors contributing to heterogeneity that can be developed as novel targets for personalized treatments.

PI_NAMEs: STERN, EMILY R (contact)

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: Address;Anterior;Behavior;behavior measurement;Behavioral;biotypes;bodily sensation;Brain;brain circuitry;Characteristics;cingulate cortex;Clinical;clinical heterogeneity;Communities;comorbidity;connectome;Data;data acquisition;Data Analyses;Depressed mood;depressive symptoms;Development;Diagnosis;Diagnostic;Dimensions;disability;Disabling;Disease;effective therapy;Etiology;Functional Magnetic Resonance Imaging;Future;Goals;Heterogeneity;Human;Individual;individual patient;Insula of Reil;Interoception;Intervention;inventory of depressive symptomatology;Investigation;Link;Machine Learning;Major Depressive Disorder;Measures;Mediating;Mental Depression;Mental disorders;Modeling;neural;neurobehavioral;neurobiological mechanism;Neurobiology;neuroimaging;novel;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Patients;Pattern;personalized intervention;personalized medicine;Phenotype;Prediction of Response to Therapy;Prefrontal Cortex;Prevalence;Protocols documentation;psychologic;recruit;Research;Research Domain Criteria;Rest;Sampling;Severities;Source;Subgroup;symptom cluster;Symptoms;Thinking;unsupervised learning;Work

PROJECT_TITLE: Behavioral and Neural Heterogeneity in OCD and Depression

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Substance Misuse;Telehealth;Underage Drinking

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Problematic alcohol use is an immense public health burden that disproportionately affects young adults, especially those with Attention Deficit/Hyperactivity Disorder (ADHD). This study will develop and test a novel mobile-health intervention that targets inhibitory control to curb real-world alcohol use. Results will yield an accessible, scalable, appealing intervention with potential to reduce problematic alcohol use among highly vulnerable young adults.

PI_NAMEs: KENNEDY, TRACI M. (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: acceptability and feasibility;Acute;addiction;Address;Adult;Affect;Age;age group;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol monitoring;alcohol risk;alcohol risk reduction;Alcohols;Attention deficit hyperactivity disorder;Awareness;behavior change;Behavior Therapy;Behavioral;binge drinker;career;Cause of Death;Cellular Phone;Clinical;cognitive process;comorbidity;Competence;Complement;computerized;Consumption;Control Groups;cost;Data;Diagnostic;Disease;drinking;Ecological momentary assessment;Effectiveness;efficacy trial;eHealth;Elements;Evaluation;experience;feasibility testing;Feedback;Female;Focus Groups;Frequencies;Future;Goals;group intervention;Health Services Accessibility;Health Technology;High Prevalence;high risk;Impairment;improved;indexing;Individual;innovation;insight;Intervention;intervention effect;Knowledge;Life;male;Measures;Mentors;mHealth;mhealth interventions;modifiable risk;Monitor;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;Persons;Pilot Projects;Population;post intervention;Process;programs;Public Health;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Risk;Risk Factors;Sampling;Science;Scientist;Self Perception;skills;social stigma;Speed;Statistical Data Interpretation;symposium;Symptoms;Test Result;Testing;Text Messaging;theories;therapy development;Time;Training;Treatment Efficacy;Treatment outcome;usability;young adult

PROJECT_TITLE: Developing a mobile-health intervention to reduce problematic alcohol use in young adults with ADHD

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: Project narrative Somatic copy-number alterations (SCNAs) and the rearrangements that generate them are, together with mutations, the major somatic genome alterations in human cancer, and understanding them yields insights into how to diagnose and treat cancers. We have extensive experience in developing methods to detect and interpret SCNAs and rearrangements and have applied these methods across tens of thousands of tumors, discovering new molecular subtypes of cancer that may benefit from new therapeutic strategies. We propose to renew our Genomics Data Analysis Center that will specialize in conducting state-of-the-art analyses of SCNAs and rearrangements from both short read and long read sequencing data to answer clinically and biologically relevant questions that are tailored to the needs of the wider Genomics Data Analysis Network.

PI_NAMEs: BEROUKHIM, RAMEEN  (contact);CHERNIACK, ANDREW DAVID

PROJECT_TERMS: Address;Admixture;admixture mapping;Algorithms;arm;Automobile Driving;Cancer Diagnostics;cancer genome;cancer subtypes;cell free DNA;Cells;Chromosome abnormality;Chromosome Structures;Chromosomes;chromothripsis;circulating DNA;Classification Scheme;Clinical;Clinical Data;Clinical Trials;Communities;Competence;Complex;Data;data integration;Dedications;Development;Diagnosis;DNA;DNA analysis;DNA Damage;DNA Repair;DNA Sequence Rearrangement;Event;Evolution;exome;experience;Genome;Genome Data Analysis Center;Genome Data Analysis Network;genome sequencing;genome wide association study;genomic locus;Genomics;Genotype;Germ Lines;Haplotypes;Heterogeneity;Human;Human Resources;Immersion;improved;Inflammatory Infiltrate;innovation;insight;International;Leadership;Link;Malignant Neoplasms;Methods;Methylation;Molecular;molecular subtypes;Mutation;Mutation Analysis;nanopore;novel therapeutic intervention;Patients;Pattern;Phase;Physicians;Play;Ploidies;reconstruction;Recording of previous events;Recurrence;repaired;Repetitive Sequence;Research;Resolution;RNA;Role;Sampling;Scientist;Shapes;single cell analysis;SNP genotyping;Structure;telomere;The Cancer Genome Atlas;Therapeutic;tool;tumor;Variant;Visualization software;whole genome;Work;working group

PROJECT_TITLE: Center for the Comprehensive Analysis of Cancer Somatic Copy-Number Alterations, Rearrangements, and Long-Read Sequencing Data


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Dementia;Down Syndrome;Genetics;Heart Disease;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Down Syndrome is the most common human genetic disease due to chromosome aneuploidy (trisomy 21), but the molecular basis for gene deregulation in these patients remains largely enigmatic or debatable, which can be partially attributed to our lack of understanding of 3D genome organization in trisomy 21 that may conceptually go beyond the limit of “gene dosage effects”. In this proposal, we apply leading-edge 4D genome technologies to pioneer an underexplored direction that the extra copy of chromosome 21 may deregulate the entire 4D genome organization in disease cells, and impact gene expression. The results of this work will have broad implications to understand, and to therapeutically treat chromosomal aneuploidy commonly seen in many human diseases, such as cancer, congenital heart diseases and neurodevelopmental disorders.

PI_NAMEs: LI, WENBO  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: 3-Dimensional;Affect;Alzheimer's Disease;Amyloid;Aneuploidy;Architecture;Area;Astrocytes;ATAC-seq;Biological Assay;Black race;Brain;brain cell;Bromodomain;Cell Differentiation process;Cell Nucleus;cell type;Cells;Chemicals;ChIP-seq;Chromatin;Chromosome 21;Chromosome abnormality;Chromosomes;congenital heart abnormality;Congenital Heart Defects;CRISPR interference;Data;Development;developmental disease;Disease;disease model;disease phenotype;DNA;Down's Syndrome;Early Onset Alzheimer Disease;Enhancers;epigenetic drug;Epigenetic Process;epigenome;Etiology;experimental study;Gene Dosage;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Diseases;Genetic Transcription;Genome;genome-wide;Goals;Hematopoietic;Hi-C;histone modification;Histones;Homo sapiens;Human;Human Chromosomes;Human Development;human disease;Human Genetics;human induced pluripotent stem cells;Impaired cognition;In Situ;Individual;induced pluripotent stem cell;Infant;inhibitor;insight;Interphase Chromosome;Knowledge;Left;Light;Malignant Neoplasms;Mediating;Methods;Microglia;Modeling;Molecular;Muscle hypotonia;nanopore;nerve stem cell;Neurodevelopmental Disorder;Neuroglia;Neurons;novel;novel therapeutic intervention;Nuclear Pore Complex;Oncogene Deregulation;optogenetics;Organoids;Pathologic;Patients;Phase;Play;Precision Run-On Sequencing;programs;Proteins;Reader;Research Personnel;RNA;Role;success;Techniques;Technology;Testing;Therapeutic;tool;transcriptome;Trisomy;Untranslated RNA;Work

PROJECT_TITLE: Beyond Gene Dosage: Understanding Down Syndrome via 4D Genome Organization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(71)R]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: Project Narrative This application, in response to RFA-ES-20-015, seeks to provide cutting-edge training and skills development to recruit individuals into environmental health science research fields. Designed for competitive graduate students, medical students, postdoctoral fellows and junior faculty, Frontiers in Environmental Science and Health (FrESH) will provide an innovative and sophisticated environmental health science education exclusively at an institution primarily serving underrepresented minority (URM) students.

PI_NAMEs: EASLEY, CHARLES A.;THOMPSON, WINSTON E (contact)

PROGRAM_OFFICER_NAME: GARTON, AMANDA E

PROJECT_TERMS: Active Learning;Address;Air Pollutants;Area;Automobile Driving;career;career development;Collaborations;college;Communities;cost effective;COVID-19 pandemic effects;design;Development;Diagnosis;Disparity;Dissemination and Implementation;Doctor of Philosophy;Education;education research;Educational workshop;Enrollment;Environment;Environmental Health;Environmental Impact;Environmental Pollutants;Environmental Science;Ethics;experience;exposed human population;Exposure to;Faculty;Flame Retardants;Fostering;frontier;Funding;Future;gene environment interaction;Goals;graduate student;hands on research;Health;Health Disparities Research;Health Personnel;health science research;higher education;Hispanic Americans;Human;implementation strategy;Individual;Inequity;innovation;Institution;Instruction;Investments;Knowledge;Laboratories;Laboratory Research;lecturer;lectures;Legal;Letters;Link;Medical Students;meetings;Mentors;Mind;minority communities;Minority Graduate Student;Minority Groups;minority patient;minority scientist;Mission;Modeling;Morehouse School of Medicine;National Institute of Environmental Health Sciences;Native Americans;next generation;novel;Outcome;outcome disparities;pandemic disease;Participant;Pesticides;pollutant;Population Sizes;Postdoctoral Fellow;programs;recruit;Research;response;science education;Scientist;Senior Scientist;Series;skill acquisition;Solid;Students;System;Target Populations;Technology;Toxic Environmental Substances;Training;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Water Pollutants


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE  The current project aims to develop and evaluate an early, brief, integrated intervention to reduce alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) symptoms after recent sexual assault. AUD and PTSD are two common intersecting health outcomes that contribute to public health care costs. Results from the proposed research will set the stage for a more rigorous randomized controlled trial of the brief intervention for AUD and PTSD, which has the potential for high impact and to be highly scalable.

PI_NAMEs: HAHN, CHRISTINE KATHRYN (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: addiction;Address;Adult;Affect;aged;Alcohol consumption;alcohol craving;alcohol intervention;alcohol research;alcohol risk;alcohol use disorder;Anxiety;Area;assault;Back;Behavior;behavior change;Behavior Therapy;behavioral clinical trial;Behavioral Mechanisms;Boston;brief alcohol intervention;brief intervention;career;career development;Clinical;Clinical Trials;clinically significant;Cognition;Cognitive Therapy;comorbidity;Conduct Clinical Trials;craving;Data;Data Analyses;Data Collection;design;Development;drinking;Early Intervention;Ecological momentary assessment;effective intervention;emotion regulation;Ensure;Event;evidence base;Evidence based intervention;Evidence based treatment;experience;Exposure to;Feedback;Focus Groups;Future;Goals;Grant;hazardous drinking;Health;Health Care Costs;improved;insight;Intervention;intervention effect;Knowledge;Life;Link;Manuscripts;Measures;Mediator;Medical;Mental Depression;Mental disorders;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Mission;Modification;National Institute on Alcohol Abuse and Alcoholism;novel;open label;Outcome;Outcomes Research;Participant;patient oriented;Pattern;Persons;pharmacologic;Phase;physical impairment;post intervention;Post-Traumatic Stress Disorders;Process;programs;Provider;Psychotherapy;Public Health;Randomized;Randomized, Controlled Trials;reduce symptoms;reduced alcohol use;Reporting;Research;Research Ethics;Research Personnel;revictimization;Science;Series;service providers;Severities;sexual assault;sexual risk taking;Site;skill acquisition;skills;South Carolina;Standardization;substance use;symposium;Symptoms;Testing;therapy development;Time;Training;Trauma;trauma exposure;traumatic event;Treatment outcome;Treatment Protocols;Universities;Woman;Women's trial;Writing

PROJECT_TITLE: Integrated Early Intervention for Alcohol Use Disorder and Posttraumatic Stress Disorder Following Sexual Assault


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: PROJECT NARRATIVE Our T35 training program provides mentored summer research opportunities for early stage medical students with the goal of inspiring a passion for biomedical research. Through hands-on research training supplemented with didactic conferences on research and career development topics, we will introduce students to the excitement and challenges of research and encourage them to pursue careers the integrate research with clinical care.

PI_NAMEs: ZELEZNIK-LE, NANCY J (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Basic Science;Biomedical Research;Cardiovascular system;career;career development;Chicago;clinical care;Clinical Research;data management;Dedications;Development;Disease;Environment;Epidemiology;experience;Experimental Designs;Funding;Genetic;Goals;Hematology;Institution;medical schools;Medical Students;Mentors;Molecular;National Heart, Lung, and Blood Institute;patient oriented;Process;Program Development;programs;Research;research and development;Research Project Grants;Research Training;responsible research conduct;skills;student training;Students;success;summer research;symposium;Training;Training Programs;Translational Research;Universities;Work

PROJECT_TITLE: Basic and Clinical Research Training for Medical Students


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Heart disease remains the leading cause of death for Americans. The proposed study will explore the novel role of a protein named YTHDF1 in the healthy and diseased heart. This work will provide new knowledge about the biology of heart muscle cells and allow for the development of new treatments for patients with heart disease.

PI_NAMEs: GOLUBEVA, VOLHA  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;Adenosine;Adult;Affect;American;Animal Model;Binding;Binding Proteins;Biological Assay;Biology;Cardiac;Cardiac Myocytes;Cause of Death;Chemicals;Co-Immunoprecipitations;cohort;Coupled;crosslink;Data;Development;Echocardiography;Enzymes;Family;Fluorescent in Situ Hybridization;functional decline;Gene Expression;Genetic;Genetic Transcription;Goals;Hand;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;Homeostasis;Homologous Gene;Hypertrophy;Immunoprecipitation;improved;innovation;Knockout Mice;Knowledge;Maintenance;Mammalian Cell;Measures;Mechanical Stress;Mediating;Mediator;member;Messenger RNA;Methylation;Microtubules;Modeling;Modification;Molecular;Molecular Biology Techniques;Monitor;morphometry;Motor;mouse model;Movement;Mus;Mutant Strains Mice;Myocardial;Names;novel;novel therapeutic intervention;particle;Pathologic;Pathway interactions;Patients;Positioning Attribute;Post-Transcriptional Regulation;pressure;Protein Biosynthesis;Proteins;Proteomics;Regulation;response;Ribonucleoproteins;ribosome profiling;RNA Processing;RNA-Binding Proteins;Role;Route;single molecule;Site;Stress;stress granule;Symptoms;Testing;Therapeutic;Time;tool;Transcriptional Regulation;transcriptome sequencing;Translational Regulation;Translations;Tubular formation;United States;Work

PROJECT_TITLE: The Role of m6A Binding Protein YTHDF1 in Cardiac Homeostasis


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Data Science;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative We propose to integrate the disparate research data, and then utilize novel statistical and AI approaches to address research questions in treating HIV and alcohol-related morbidity and mortality. The proposed study will unleash the potential of data and information, accelerate knowledge discovery, advance data-powered health, and transform discovery to improve health outcomes for people living with HIV.

PI_NAMEs: COOK, ROBERT L (contact);WU, SAMUEL S

PROJECT_TERMS: Acceleration;Address;Alcohol consumption;alcohol research;alcohol use disorder;Alcohols;Applications Grants;Artificial Intelligence;Behavioral;Big Data;Biological;Biometry;Biotechnology;Caring;catalyst;Clinical Data;Clinical Sciences;co-infection;Communities;comorbidity;Complex;Computerized Medical Record;Data;data access;Data Analyses;Data Analytics;data centers;data ingestion;data integration;data management;data privacy;data repository;data resource;data reuse;Data Science;Data Set;data sharing;Data Sources;data standards;Development;Devices;Disease Progression;Disparate;Epidemic;Etiology;Faculty;FAIR principles;Florida;Funding;Goals;Health;Health Services Research;Hepatitis C;HIV;HIV Infections;HIV/AIDS;improved;insight;Intervention;Knowledge;Knowledge Discovery;Machine Learning;Medical Imaging;meetings;mHealth;Monitor;Morbidity - disease rate;mortality;multimodal data;multimodality;Multiomic Data;National Institute on Alcohol Abuse and Alcoholism;novel;online community;Online Systems;Outcome;Paper;Parents;Pathogenicity;Persons;Physiology;Policy Research;Predisposition;Preparation;prevent;privacy protection;Procedures;Process;Protocols documentation;Publications;repository;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;sharing platform;Source;Standardization;Surveillance Program;Surveys;System;Technology;Training;training opportunity;Training Programs;Translational Research;transmission process;Trust;Tuberculosis;United States;United States National Institutes of Health;Universities;user-friendly;virtual

PROJECT_TITLE: Southern HIV and Alcohol Research Consortium Biomedical Data Repository

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Sleep Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Chronic inflammation has emerged as a biomarker of interest linking low socioeconomic status (SES) with disease risk; however, the development of socioeconomic differences in inflammation during adolescence and the biobehavioral and psychosocial underpinnings of the link are not well understood. The present study explores SES associations with markers of inflammation during a window of substantial psychological, biological, and social change—the transition from adolescence to adulthood—with the goal of identifying factors that may explain how SES influences risk for inflammation. Findings from this research can provide foundational knowledge on the development of socioeconomic disparities in health and identify potential routes for intervention (e.g., improving sleep and social connection) to reduce health risk for youth of low socioeconomic backgrounds, supporting NICHD’s mission to enhance the lives and wellbeing of adolescents.

PI_NAMEs: ROCHA, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: actigraphy;Address;Adolescence;Adolescent;adolescent health;Adult;Anti-Inflammatory Agents;biobehavior;Biological;Biological Markers;Blood;cardiovascular disorder risk;Characteristics;Chronic;circulating biomarkers;college;cost;cytokine;Data;Data Set;Development;Discrimination;disorder risk;Disparity;Dryness;Economics;Education;eleventh grade;Enrollment;experience;Face;Family;Gene Expression;Genes;Goals;Health;health disparity;high school;higher education;Immune;improvement on sleep;Income;Inflammation;Inflammatory;inflammatory marker;interest;Intervention;Investigation;Knowledge;life span;Link;Literature;Loneliness;Longitudinal Studies;low socioeconomic status;Measurement;Measures;Mediating;Mission;National Institute of Child Health and Human Development;Participant;Pathway interactions;Personal Satisfaction;physical conditioning;poor health outcome;Positioning Attribute;Process;psychologic;psychosocial;Psychosocial Factor;Psychosocial Stress;psychosocial stressors;Reporting;Research;Risk;Role;Route;Sampling;Sleep;sleep behavior;Sleep disturbances;sleep quality;social;Social Change;Social isolation;social relationships;Social status;socioeconomic development;socioeconomic disparity;Socioeconomic Status;socioeconomics;Spottings;Stress;Time;transition to adulthood;Uncertainty;Work;young adult;Youth

PROJECT_TITLE: Socioeconomic Status and Inflammation Across the Transition from Adolescence to Adulthood

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: POTSDAM

ORG_NAME: CLARKSON UNIVERSITY

PHR: Project Narrative BRAIN-STEM The goal of this project is to increase the number of students from rural areas who pursue careers in healthcare with the understanding that one of the strongest and most consistently reported predictors of practicing in rural areas is where one grew up. This will be accomplished by developing an educational program that increases academic, research, and metacognitive skills important for succeeding in the STEM subjects relevant to healthcare profession training. This project will further benefit society by sparking interest in and providing foundational knowledge about relevant health issues in neuroscience, addiction and concussion, that high school students and teachers can affect within their own community.

PI_NAMEs: KAVANAGH, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: addiction;Address;Affect;after-school program;Area;aspirate;Behavioral Sciences;Brain;Brain Concussion;career;career awareness;Career Choice;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communities;design;Development;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Evidence Based Medicine;Faculty;faculty mentor;Foundations;Goals;Health;Health Professional;Healthcare;High School Student;improved;Individual;Information Management;Infrastructure;innovation;inquiry-based learning;interest;Journals;Knowledge;Mentors;Methods;Monitor;Morbidity - disease rate;mortality;Neurosciences;Next Generation Science Standards;open source;outreach program;Participant;peer;Performance;Physicians;Play;Preparation;Process;profession allied to medicine;Professional Practice;programs;Publications;Reporting;Research;Research Project Grants;Role;role model;Rural;rural area;Rural Community;school district;school health;Science;Science, Technology, Engineering and Mathematics;Self Efficacy;skill acquisition;skills;Societies;Socioeconomic Status;student mentoring;Students;suburb;symposium;teacher;Teacher Professional Development;Techniques;Technology;Training;twelfth grade;Universities;university student;web app;Work

PROJECT_TITLE: Building Rural Aspirations In Neuroscience with Science, Technology, Engineering, and Mathematics (BRAIN-STEM)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE The current arms-race that exists between drug discovery and the bacterial pathogens that rapidly develop resistance against these new antibiotics can be ended by interfering with the key evolutionary processes that enable resistance to emerge. Herein, we untangle the importance of the cell-states of tolerance, persistence and hetero-resistance in their roles as harbingers of antibiotic treatment failure (ATF) and enablers of resistance. We identify the treatment regimens that select for ATF cell-state induction, uncover the genetic mechanisms underlying their emergence, devise strategies to target their collateral sensitivities, and develop a proof-of- principle computational diagnostics approach that predicts the presence and frequency of ATF cell-states in complex bacterial populations.

PI_NAMEs: COOPER, VAUGHN ;ISBERG, RALPH R.;ROSCH, JASON W.;VAN OPIJNEN, TIM  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acinetobacter baumannii;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Resistance;arms race;Bacterial Infections;Bioinformatics;Biological Models;blind;Cells;Characteristics;Collaborations;Collection;Complex;cost;Data;design;Detection;Development;Diagnostic;diagnostic assay;diagnostic strategy;drug discovery;Drug Targeting;Early Diagnosis;emerging antibiotic resistance;emerging antimicrobial resistance;Environment;Equation;Etiology;Evolution;Failure;fitness;Frequencies;Genetic;genetic association;genomic tools;Genomics;Genotype;Goals;Heel;Immune system;In Vitro;in vivo;Individual;Infection;innovation;Intermediate resistance;Libraries;Maps;member;Minority;Mutation;novel diagnostics;novel strategies;novel therapeutics;Organism;pathogenic bacteria;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phenotype;Population;Predisposition;pressure;prevent;Principal Investigator;Process;Recording of previous events;Regimen;Resistance;Resistance development;resistance gene;resistance mutation;Role;Running;Sampling;Side;Source;Streptococcus pneumoniae;Stress;synergism;Testing;transcriptional reprogramming;transcriptome sequencing;Treatment Failure;Treatment Protocols;Variant;Work

PROJECT_TITLE: Attacking failure of antibiotic treatment by targeting antimicrobial resistance enabler cell-states


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: VAN OPIJNEN, TIM  (contact)

PROJECT_TERMS: Adherence;Administrator;Advisory Committees;Antibiotic Therapy;Antimicrobial Resistance;Award;Bioinformatics;Budgets;Cells;Clinical;clinical material;Collaborations;Combating Antibiotic Resistant Bacteria;Communication;Critiques;Data;Ensure;Evaluation;Event;Failure;Genomics;Goals;Guidelines;Human Resources;Individual;Intellectual Property;Interdisciplinary Study;Laboratories;Leadership;Light;meetings;Mentors;Mutation;National Institute of Allergy and Infectious Disease;new technology;Occupational activity of managing finances;operation;Patients;Performance;Persons;Play;Principal Investigator;programs;Progress Reports;Research;Research Personnel;Research Project Grants;Resistance;Resources;Role;Route;Services;Students;success;Suggestion;symposium;synergism;Technology Transfer;Training;Travel;Treatment Failure;U-Series Cooperative Agreements;virtual;Vision

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Diabetes;Wound Healing and Care

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Non-healing wounds are a major diabetic complication and represent a major public health burden. This work addresses how communication between skin cells and immune cells, mediated by skin cell-derived nanocarriers called exosomes, is interrupted by diabetes which in turn causes chronic inflammation. This work will help understand why diabetic wounds are refractory to current clinical care and provide cues on how to troubleshoot.

PI_NAMEs: GHATAK, SUBHADIP  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Address;Biology;Blood;Body Fluids;cell type;Cells;Chemicals;Chronic;chronic wound;clinical care;Communication;Complications of Diabetes Mellitus;Cues;Data Analyses;Dedications;Dermis;Diabetes Mellitus;diabetic;diabetic ulcer;Epidermis;exosome;extracellular vesicles;Foundations;Genes;Genetic;genetic information;glycosylation;Granulocyte-Macrophage Colony-Stimulating Factor;healing;healthcare burden;Heterogeneous-Nuclear Ribonucleoproteins;Homing;Human;Immune;Immune response;Impairment;Inflammation;Inflammation Mediators;Inflammatory;insight;interest;Interleukin-2;Interruption;Isomerism;keratinocyte;Label;Laboratories;Liquid substance;Literature;Macrophage;Mannose;Mediating;Medicine;Membrane Glycoproteins;Membrane Proteins;Messenger RNA;MicroRNAs;Modification;nanocarrier;non-diabetic;non-healing wounds;novel;Patients;Phase;Process;programs;Protein Chemistry;Public Health;public health relevance;Publications;re-epithelialization;Refractory;Research Personnel;Resolution;Rest;RNA Binding;Site;Skin;skin wound;Skin wound healing;stem;Structure;sugar;Surface;Techniques;Testing;timeline;Tissues;tool;Untranslated RNA;uptake;Visit;Work;wound;wound closure;wound healing

PROJECT_TITLE: Exosomes in wound healing

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Nanotechnology

PI_NAMEs: COOPER, VAUGHN  (contact)

PROJECT_TERMS: Address;Antibiotic Therapy;Antimicrobial Resistance;automated analysis;Bacterial Genome;Bar Codes;Bioinformatics;Cells;Communities;comparative genomics;CRISPR interference;Custom;Data;data exploration;data sharing;data to knowledge;Databases;deep sequencing;Democracy;Deposition;Development;DNA analysis;DNA methylation profiling;droplet sequencing;Educational process of instructing;Educational workshop;Failure;flexibility;forest;Genes;Genome;Genomic DNA;Genomics;Genotype;Goals;graphical user interface;Guppy;Heterogeneity;High-Throughput Nucleotide Sequencing;host-microbe interactions;Immunity;innovation;Institution;Leadership;Libraries;Maps;Mediating;member;Metagenomics;Methodology;Methods;methylome;Microbe;Modification;nanopore;Nomenclature;Nucleic Acids;Orthologous Gene;pathogen;Performance;Population;portability;Preparation;Protein Isoforms;public database;Publishing;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;RNA;Salmon;screening;Shotguns;Stream;tool;Training;Transcript;transcriptome sequencing;transposon sequencing;Treatment Failure;Universities;Visualization;web app

PROJECT_TITLE: Bioinformatics Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PROJECT_TERMS: Acinetobacter baumannii;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Resistance;bacterial resistance;Bar Codes;Biological Assay;candidate identification;candidate marker;cell growth;Cell Physiology;Cells;Clinic;Clinical;clinical development;clinical epidemiology;clinically relevant;clinically significant;Collaborations;Communicable Diseases;Complement;Complex;CRISPR interference;Cultural Evolution;Data;Development;Disease;drug action;Drug resistance;Drug Tolerance;end of life;Engineering;Essential Genes;Evaluation;Event;Evolution;experimental analysis;experimental study;Failure;Family;fitness;Genetic;Genetic Markers;Genetic Transcription;Genotype;Goals;Gram-Negative Bacteria;Growth;Health;Heterogeneity;Hospitals;Immune;In Vitro;in vivo;Insertional Mutagenesis;Intermediate resistance;Lesion;Link;member;Microbe;microbial;Microbial Biofilms;Modeling;Multi-Drug Resistance;Mus;mutant;Mutation;Nosocomial pneumonia;Organism;Patients;Phagocytes;Pharmaceutical Preparations;Phenotype;Pneumonia;pneumonia model;Population;Property;Protein Biosynthesis;Reporter;Resistance;resistance mutation;Resolution;Risk;Role;Series;Shotguns;Source;Streptococcus pneumoniae;Stress;System;Testing;Therapeutic Agents;Time;Treatment Failure;Variant;Work

PROJECT_TITLE: Drug resistance enablers and their role in antibiotic treatment failure


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention

PI_NAMEs: ROSCH, JASON W. (contact)

PROJECT_TERMS: Address;Affect;Antibiotic Resistance;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Antimicrobial Resistance;Bacterial Infections;bacterial metabolism;biological adaptation to stress;Cell Physiology;Cells;Chemicals;Clinical;Coal;Development;Evolution;Failure;Genetic;genetic manipulation;Genetic Transcription;Genotype;improved;in vivo;Infection;insight;Intermediate resistance;Investigation;Medical;Metabolic;Metabolism;Methodology;Microfluidic Analytical Techniques;Modeling;Morbidity - disease rate;mortality;mutant;Mutation;Pathway interactions;Patient-Focused Outcomes;Phenotype;Play;Population;Population Analysis;prevent;Probability;Production;Regulatory Pathway;Resistance;resistance mechanism;response;Role;screening;Serinus;Signal Transduction;Streptococcus pneumoniae;Stress;synergism;Therapeutic;tool;Treatment Failure;treatment optimization;Treatment outcome

PROJECT_TITLE: Collateral Consequences of Enabler Genotypes in Antibiotic Treatment Failure.


ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Sepsis is a severe life-threatening response to infection that results in over 270,000 deaths in the U.S. annually. The one-size-fits-all approach to treating sepsis has not worked, and thus it is essential to identify distinct sepsis subgroups that may have differential responses to treatments. This proposal applies cutting-edge machine learning algorithms to bedside vital signs (e.g., temperature, heart rate, etc.) to identify sepsis subgroups with differential responses to treatments, thus opening the doors for the precision medicine approach to sepsis.

PI_NAMEs: BHAVANI, SIVASUBRAMANIUM  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Algorithms;Anti-Inflammatory Agents;autoencoder;biobank;Bioinformatics;Biological;Biological Markers;Cardiovascular system;career;career development;Cessation of life;Classification;Clinical;Clinical Informatics;Clinical Trials;clinically relevant;cohort;Communication;comparative;computer-assisted diagnostics;Critical Care;Critical Illness;crystalloid;cytokine;Data;Data Science;Data Set;Death Rate;deep learning;deep neural network;Development;diagnostic tool;Early identification;Electronic Health Record;Funding;Future;Goals;Healthcare Systems;Heart Rate;Heterogeneity;Hospital Costs;Hospitalization;Hour;Immune;immune modulating agents;Immune response;Immune system;Immunologic Markers;Immunologics;Immunophenotyping;Infection;innovation;Inpatients;Intervention;IV Fluid;Kidney;Life;Liquid substance;Machine Learning;machine learning algorithm;Maps;Measurement;Measures;Medicine;Mentors;Methods;Modeling;mortality;multiplex assay;Normal saline;novel;Outcome;Patients;personalized medicine;Phenotype;Physicians;Physiological;Physiology;Plasma;precision medicine;predicting response;Process;programs;Publishing;Research;response;Resuscitation;Scientist;Sepsis;Sepsis Syndrome;septic patients;Societies;Subgroup;symposium;Syndrome;Temperature;Time;Training;Training Programs;treatment planning;treatment response;United States National Institutes of Health;unsupervised learning;Validation;Work

PROJECT_TITLE: Identification of Precision Sepsis Subphenotypes Using Vital Sign Trajectories


PHR: Project Narrative Increased lipid production is essential for cancer cell survival, and numerous recent publications indicate a central role for the SREBP pathway in various cancers, including prostate cancer. African American males—who already have 2.6 times higher mortality from prostate cancer than Caucasian males—appear to have up to four- fold greater risk of developing prostate cancer in the context of obesity. Our proposed studies will help generate a rich body of evidence supporting successful targeting of lipid signaling for the treatment of lethal prostate cancer.

PI_NAMEs: KAOCHAR, SALMA  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: abiraterone;African American;androgen independent prostate cancer;Androgen Receptor;Androgens;Animal Model;anticancer activity;aqueous;Binding Proteins;Biological Availability;Biotechnology;Body mass index;cancer cell;Cancer Etiology;Cancer Patient;Castration;Caucasians;Cell Line;Cell Membrane Permeability;Cell Survival;Cells;Cessation of life;Cholesterol;Clinical;cohort;Collaborations;Data;design;Diagnosis;docetaxel;Drug Combinations;enzalutamide;Enzymes;FASN gene;FDA approved;first-in-human;Future;Genes;Goals;High Fat Diet;improved;In Situ;In Vitro;in vivo;in vivo Model;Incidence;inhibitor;innovation;Lead;Ligand Binding Domain;Link;lipid biosynthesis;lipid metabolism;lipidome;lipidomics;Lipids;male;Malignant neoplasm of prostate;Malignant Neoplasms;Membrane Lipids;men;Metabolic;Metabolism;Missense Mutation;mortality;mTOR Signaling Pathway;Mus;neoplastic cell;novel;novel therapeutics;Obesity;Oncogenic;Oral;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patient Selection;Patients;Pharmaceutical Preparations;PIK3CG gene;Post-Translational Protein Processing;pre-clinical;preclinical study;Production;Proliferating;Property;prostate cancer cell;prostate cancer model;prostate cancer progression;protein activation;protein expression;Publications;Regulatory Element;Resistance;Risk;Role;Safety;Series;Signal Transduction;small molecule inhibitor;Solid Neoplasm;Solubility;Specimen;SRE-1 binding protein;Sterols;Testing;Therapeutic;therapeutic target;Tissues;transcription factor;transcriptome;tumor;United States;Unsaturated Fatty Acids;uptake;Variant;Veterans;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting Castration Resistant Prostate Cancer via Potent Inhibition of Signaling Lipids

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention

PROJECT_TERMS: Affect;Algorithms;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Bacteria;blind;cancer cell;cancer type;Cells;Clinical;clinical diagnostics;Communicable Diseases;Complex;Custom;Data;Data Set;design;Detection;Development;diagnostic assay;diagnostic development;diagnostic strategy;Disease;Drug resistance;Early Diagnosis;Entropy;Epigenetic Process;experience;experimental study;Exposure to;Failure;Frequencies;Future;Genes;Genetic Transcription;Goals;Immune system;Immunocompromised Host;Immunotherapeutic agent;improved;In Vitro;in vivo;Infection;Intermediate resistance;Link;Machine Learning;machine learning algorithm;magnetic beads;Maintenance;Malignant Neoplasms;Maps;Measurement;Methods;Minority;Modeling;Mus;Mutation;nano-string;nanopore;novel diagnostics;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Physicians;Population;Predisposition;pressure;prevent;reconstitution;Resistance;resistance mutation;response;Sampling;Serum;single-cell RNA sequencing;Source;Speed;Stress;targeted treatment;Technology;technology development;Testing;Time;Tissues;tool;transcriptome sequencing;Treatment Failure;treatment strategy;Tumor Tissue;Validation;Work

PROJECT_TITLE: A blind source separation approach for deconvolution of bulk transcriptional data leads to early detection of ATF cell-states in complex bacterial populations, in vitro and in vivo


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases;Prevention;Wound Healing and Care

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: PROJECT NARRATIVE This project aims to demonstrate the feasibility of a fully integrated, wirelessly operated catheter dressing for the early detection of catheter-related sepsis. The objectives of this proposal are consistent with the goals of the NIH NIGMS Technology Development Program R21 and will have a significant impact on public health by forming the basis for real-time non-invasive and on-body monitoring of an extended range of bacterial species, including antibiotic-resistant bacterial growth. This integrated device can transform the current practices, improve the patients’ quality of life and the ability of clinicians to treat the patients much earlier than the current clinical practice, and help reduce the morbidity and mortality rates and associated healthcare costs.

PI_NAMEs: CEYLAN KOYDEMIR, HATICE  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Adherence;Affect;Animal Model;Animals;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteremia;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Biological Assay;Biosensor;Catheter-related bloodstream infection;Catheters;Central Venous Catheterization;Chemicals;Classification;Clinical;clinical practice;Collaborations;college;cost;Custom;Data;data acquisition;Data Analyses;data communication;Death Rate;design;Detection;Development;Devices;diagnostic technologies;dietary restriction;Early Diagnosis;Early treatment;Electronics;Equipment;Escherichia coli;Excision;experimental study;Exploratory/Developmental Grant;flexibility;Foundations;Goals;Growth;Guidelines;handheld mobile device;Health Care Costs;Hospitalization;Human;improved;Infection;infection risk;Knowledge;Life;light weight;Machine Learning;Measures;Methods;Microfabrication;microorganism;migration;Monitor;Morbidity - disease rate;National Institute of General Medical Sciences;Nature;Outcome;Patients;Performance;Persons;point of care;point-of-care diagnostics;portability;pre-clinical;prototype;Public Health;Quality of life;real time monitoring;Research;Resources;response;Science;sensor;Sepsis;Signal Transduction;Site;skills;Skin;skin microbiota;Sterile coverings;Study models;Systems Development;technology development;technology research and development;Testing;Texas;Time;United States National Institutes of Health;Universities;Veterinary Medicine;wearable device;wireless;wireless transmission;Wound Infection

PROJECT_TITLE: An Integrated Catheter Dressing for Early Detection of Catheter-related Bloodstream Infections

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: DENVER

ORG_NAME: WESTERN STATES CANCER RESEARCH NCORP

ORG_STATE: CO

PHR: Project Narrative The Colorado Cancer Research Program is a cancer clinical trial research organization who seeks to provide access to NCI sponsored clinical trials for our consortium members located in the mountain states of Colorado, Wyoming, Montana, Utah, Washington and Alaska. By partnering with Healthcare systems and community hospitals, we will provide access to innovative therapies and cancer related research projects for patients in their home communities, all the while, pursuing and supporting NCI strategic research priorities. We work with Healthcare systems, Hospitals, Providers and Patients to disseminate knowledge about clinical trial options, clinical trial participation, and clinical trial outcomes.

PI_NAMEs: DIBELLA MD, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Advanced Malignant Neoplasm;Alaska;anti-cancer research;base;cancer care;cancer clinical trial;Cancer Control;cancer health disparity;cancer prevention;Cancer Research Project;care delivery;Caring;Catchment Area;Clinical Research;Clinical Trials;Collaborations;Collection;Colorado;Communities;Community Clinical Oncology Program;Community Hospitals;community setting;Dedications;Disease;Enrollment;Funding;Future;Goals;Grant;Group Meetings;health care service;Health Personnel;Health Professional;Healthcare Systems;Home;Hospitals;Image;innovation;Innovative Therapy;Institution;Knowledge;Malignant Neoplasms;Measures;member;Mentors;Minority Participation;Montana;multidisciplinary;Native American population;Newsletter;Oncology;operation;Outcome;outreach;patient oriented;Patients;Pediatric Hospitals;Pediatric Oncology;Physicians;Physicians' Offices;Population;precision medicine;Private Practice;programs;Protocols documentation;Provider;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Site;social media;symposium;System;Training;Travel;treatment trial;Underrepresented Populations;Utah;Washington;Work;Wyoming

PROJECT_TITLE: Western States Cancer Research NCORP


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Prevention

ORG_CITY: GREENVILLE

ORG_NAME: PRISMA HEALTH - UPSTATE

PHR: PROJECT NARRATIVE A robust clinical trials program is relevant to achieving advances in addressing unmet needs of cancer patients in the realm of treatment, cancer control, prevention, and care delivery. NCORP of the Carolinas is positioned to provide a sustained, powerful influence on cancer care through research in the community setting.

PI_NAMEs: CHUNG, KI YOUNG (contact)

PROJECT_TERMS: Address;Adult;Advocate;Aftercare;anti-cancer research;base;Businesses;cancer care;Cancer Control;cancer health disparity;Cancer Patient;cancer prevention;care delivery;Caring;Catchment Area;Childhood;Chromosome Mapping;Clinical;clinical imaging;clinical practice;Clinical Trials;Collection;Communities;Community Clinical Oncology Program;community engagement;community organizations;community research;community setting;Continuity of Patient Care;cost;County;data management;data submission;Dedications;Development;Disparity;eligible participant;Employee;Enrollment;Ensure;evidence base;Family;Future;Goals;Grant;Growth;Health;Health care facility;Health system;Healthcare Systems;Hospitals;human subject;Image;imaging study;improved;Individual;individualized medicine;Institutional Practice;Joints;Knowledge;Malignant Neoplasms;marginalization;medical specialist;meetings;Mentors;Methods;Minority;Minority Groups;Mission;Molecular Target;Oncologist;Outcome;outreach;Palliative Care;Participant;participant enrollment;patient engagement;patient outreach;Patient-Focused Outcomes;Patients;Pediatric Research;Phase;Physicians;Positioning Attribute;Prevention;Prevention trial;programs;Protocol Compliance;Quality of life;recruit;Research;Research Personnel;research study;Resources;screening;screening program;Services;Societies;South Carolina;Strategic Planning;Study Subject;success;symptom management;Technology;Time;treatment trial;Underrepresented Populations;Underserved Population

PROJECT_TITLE: NCORP of the Carolinas (Greenville Health System NCORP)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE UNC-13 is a large synaptic protein that is important for several synaptic fusion processes, including synaptic vesicle (SV) docking and priming, lipid-binding, and SNARE complex assembly/disassembly regulation. Mutations in the HC2M and MUN domains of UNC-13 are associated with developmental disorders, seizures, and musculoskeletal abnormalities. Our research plan uses a combination of genetic, behavioral, and biochemical methods to investigates the mechanism of UNC-13 in synaptic transmission with a particular focus on the MUN and HC2M domains.

PI_NAMEs: SHAHANOOR, ZIASMIN  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Automobile Driving;Behavioral;Binding;Biochemical;Biochemistry;Brain;Bypass;C-terminal;Caenorhabditis elegans;Cell membrane;Cells;Chemicals;Communication;Complex;Congenital musculoskeletal anomalies;Data;developmental disease;Docking;Event;Future;gain of function;Genetic;Human;Image;imaging approach;in vivo evaluation;in vivo imaging;Lead;Lipid Binding;loss of function;Mediating;Membrane Fusion;Methods;model organism;Modeling;molecular assembly/self assembly;Monitor;Mouse Protein;mutant;Mutation;Names;Nervous System Disorder;Nervous System Physiology;Neurons;neurotransmitter release;Neurotransmitters;novel;Orthologous Gene;Paper;Phenotype;Point Mutation;presynaptic;Presynaptic Terminals;prevent;Process;protein distribution;Proteins;Proteomics;Quality Control;Regulation;Research;Role;Seizures;Site;SNAP receptor;Solid;Synapses;synaptic function;Synaptic Transmission;Synaptic Vesicles;synaptotagmin;syntaxin 1;Testing;UNC13B gene;Work

PROJECT_TITLE: Leveraging the genetics and biochemistry of UNC-13 to uncover mechanisms driving neurotransmitter secretion


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Pulmonary Hypertension

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: NARRATIVE Right ventricular failure (RVF) is a prevalent cause of cardiovascular collapse and a major public health problem. Unlike left ventricular failure, RVF is not frequently investigated, which has contributed to the lack of effective therapies for RVF. Here we propose to use computational model predictions, based on state-of-the-art, multi- scale, comprehensive experimental datasets, to improve our understanding of RVF.

PI_NAMEs: BAKER, ANTHONY J.;BEARD, DANIEL A;CHESLER, NAOMI C (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Adult;Affect;Apoptosis;Biological Assay;Blood capillaries;Cardiac;Cardiac Output;cardiovascular collapse;Cause of Death;Computer Models;constriction;coronary fibrosis;crosslink;Data;Data Set;Disease;effective therapy;exercise capacity;exercise intolerance;experience;experimental study;Exposure to;Failure;Fibrosis;Functional disorder;Generations;Goals;Hand;Heart;Human;human disease;Human Rights;Hypertrophy;Impairment;improved;in vivo;Individual;Kinetics;Left;Measurement;Measures;Mechanics;Microfilaments;Mitochondria;Modeling;Morbidity - disease rate;mortality;multi-scale modeling;Muscle Cells;Myocardial tissue;Myocardium;Nature;Necrosis;novel;Organ;Organelles;Organism;Oxidative Stress;Patients;Phenotype;predictive modeling;preservation;pressure;prevent;Protocols documentation;Public Health;pulmonary arterial hypertension;Pulmonary artery structure;pulmonary vascular remodeling;Rattus;Relaxation;Respiration;right ventricular failure;Right ventricular structure;Rodent;Rodent Model;Sampling;Severities;Techniques;Testing;Time;Tissues;Ventricular;Whole Organism;Work

PROJECT_TITLE: Multiscale mechanobiology of right ventricular failure

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Prevention;Primary Health Care;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

ORG_STATE: MN

PHR: Most oral health professionals advise patients who smoke to quit, but few connect patients directly to smoking cessation medication, which is an essential component of evidence-based smoking cessation treatment. Based on findings from previous trials, this cluster randomized, hybrid type 1 implementation-effectiveness trial will test whether combining brief advice with nicotine replacement therapy (NRT) sampling, which refers to providing patients who smoke with free samples of over-the-counter nicotine patches and nicotine lozenges, during a routine dentist visit increases rates of abstinence, quit attempts, and use of NRT. The results of the proposed research have potential for important clinical and policy significance with regard to reducing tobacco-related morbidity and mortality.

PI_NAMEs: JAPUNTICH, SANDRA JANE (contact)

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: Abstinence;acceptability and feasibility;Address;American;Attitude;Behavior;Behavior Control;brief advice;brief intervention;Cigarette;cigarette smoking;Clinical;clinical practice;clinical trial implementation;Clinical Trials;Communities;cost effectiveness;Cost Effectiveness Analysis;Counseling;Data;Databases;Dental;Dental Care;Dental General Practice;Dental Hygienists;Dentists;Disease;Documentation;Drug Prescriptions;Education;Effectiveness;effectiveness testing;effectiveness/implementation trial;evidence base;Evidence based treatment;Failure;Feedback;future implementation;Goals;Guidelines;Health Professional;Hour;Hybrids;Hygiene;implementation efforts;implementation evaluation;improved;Incidence;innovation;Instruction;interest;Intervention;Intervention Studies;Interview;Knowledge;long term abstinence;malignant mouth neoplasm;Manuals;Midwestern United States;Morbidity - disease rate;mortality;Motivation;Nicotine;nicotine patch;nicotine replacement;nicotine use;optimism;oral care;Oral health;Patients;Periodontal Diseases;Pharmaceutical Preparations;Phase;pilot test;pilot trial;Policies;post intervention;Postoperative Period;practice-based research network;Preparation;Prevalence;prevent;primary outcome;Procedures;process evaluation;Promoting Action on Research Implementation in Health Services framework;Protocols documentation;Provider;quitline;Randomized;Readiness;Recommendation;recruit;reduce tobacco use;Relapse;Research;Safety;Sampling;Self Efficacy;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;State Interests;Surveys;Testing;Tobacco;Training;translational potential;treatment as usual;trial comparing;trial planning;Visit;wound healing

PROJECT_TITLE: Effectiveness of Nicotine Replacement Therapy Sampling in Dental Practices