NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: PROVO

ORG_NAME: BRIGHAM YOUNG UNIVERSITY

PHR: PROJECT NARRATIVE A major goal of addiction research is to characterize novel treatment targets for alcohol use disorder and alcoholism and peripheral biomarkers of the addictive state that would enable objective monitoring of treatment. Research has established that the rewarding and addictive properties of alcohol are mediated by the dopamine reward system, yet little is known how alcohol disrupts dopamine transmission in the brain. Similarly, little is known about how local immune cells signal to mesolimbic circuits. The rationale for this proposal is predicated on the belief that advancement in the understanding of the neuroimmune mechanisms underlying the recreational use and abuse potential of alcohol will pave the way for more effective, personalized treatment strategies that could reverse dependence on alcohol and save lives and resources throughout the world.

PI_NAMEs: YORGASON, JORDAN THOMAS (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: abuse liability;Acute;addiction;alcohol behavior;Alcohol consumption;alcohol effect;alcohol exposure;alcohol reinforcement;alcohol reward;alcohol use disorder;Alcoholism;Alcohols;antagonist;Anti-Inflammatory Agents;ATP Receptors;Behavior;Behavioral;Belief;Biological;Biological Markers;Blood;Brain;Cell Death;Cell surface;Chemotactic Factors;Chemotaxis;Chronic;Complex;conditioned place preference;cytokine;Cytometry;Data;Dependence;Development;Disinhibition;Dopamine;Dopamine D2 Receptor;dopaminergic neuron;Dose;drug development;Ethanol;Ethanol dependence;Fluorescence;gamma-Aminobutyric Acid;Goals;Immune;immune activation;improved;in vivo;indexing;interdisciplinary approach;Interleukins;Intoxication;intraperitoneal;Intravenous;Investigation;Knock-in;Knowledge;Label;lens;Leukocytes;Lipopolysaccharides;Literature;Macrophage;Measures;Mediating;Microglia;Microscopy;Midbrain structure;Molecular;Monitor;monocyte;Morphology;Motility;Motor Activity;mouse model;multi-photon;multiphoton microscopy;Mus;neural;Neurobiology;neurochemistry;Neuroimmune;Neuroimmunomodulation;neuronal excitability;Neurons;Neurotransmitters;novel;optical sensor;Optics;Periodicity;Peripheral;personalized medicine;Phagocytes;pharmacologic;Pharmacology;photon-counting detector;Process;Property;Purinoceptor;receptor;receptor expression;Recreation;redshift;Research;Resources;Rewards;Role;Scanning;sensor;sex;Signal Transduction;Slice;System;Techniques;Testing;theories;TNF gene;tool;trafficking;Transgenic Mice;transmission process;treatment strategy;Ventral Tegmental Area

PROJECT_TITLE: Neuroimmune mechanisms of alcohol reward

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: GRAHAM, ALICE M;SULLIVAN, ELINOR L. (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 12/24 Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Childhood Injury;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Prevention

ORG_CITY: DALLAS

ORG_DEPT: PEDIATRICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Extracorporeal membrane oxygenation (ECMO) is a technology to support the failing heart or lungs, allowing time for the injured organ to heal or bridge the patient to transplant; major neurological injury is seen in more than 1/3 of survivors, leading to long-term neurological deficits. The resulting financial costs and reduction in quality-of-life places enormous burdens on patients, their families, and society: the ability to identify risks and initiate a process to mitigate them would be a major advancement in the field. The proposed research will use advanced machine learning algorithms to build a predictive model that will be refined and validated with ongoing input from clinicians, identify modifiable risk factors for future studies, and thereby enable strategies to decrease long-term morbidity and mortality from neurological injury.

PI_NAMEs: RAMAN, LAKSHMI  (contact)

PROGRAM_OFFICER_NAME: BROWN, JEREMY

PROJECT_TERMS: Accounting;Acids;Acute;Adult;Algorithms;Anticoagulation;Artificial Intelligence;base;Brain Injuries;Cardiopulmonary;Cardiopulmonary Bypass;cerebral hemodynamics;Cerebrum;Characteristics;Child;Childhood Injury;Classification;Clinical;Clinical Data;clinical decision-making;clinically significant;Coagulation Process;cohort;Computerized Medical Record;conventional therapy;COVID-19 pneumonia;Critical Care;Critical Illness;Critically ill children;Data;deep learning;Development;Diagnosis;Drops;Early Intervention;Electroencephalography;Elements;Etiology;Event;Extracorporeal Membrane Oxygenation;Failure;Family;Financial cost;Foundations;Future;Goals;Growth;healing;Heart;Hemorrhage;high risk;Hour;Impairment;improved;Individual;individual patient;Inflammation;Injury;interest;Intervention;Intervention Studies;Knowledge;Laboratories;Learning;learning algorithm;Legal patent;Life;Lung;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Measures;Modeling;modifiable risk;Monitor;Morbidity - disease rate;mortality;multidisciplinary;neonate;Nervous System Trauma;neuroimaging;Neurologic;Neurologic Deficit;Neurological observations;Neurological outcome;neuroprotection;novel;Organ;organ injury;Outcome;patient population;patient subsets;Patients;Pattern;Perfusion;personalized intervention;Physiological;Pilot Projects;Play;prediction algorithm;predictive modeling;Probability;Process;Quality of life;Research;Risk;Risk Assessment;Risk Factors;risk prediction model;Role;Scientist;Societies;Stroke;Survivors;Techniques;Technology;Testing;Time;tool;Training;Transplantation;Update;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Predicting ECMO NeuroLogICal Injuries using mAchiNe Learning (PELICAN)

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: IOWA CITY

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The proposed continuation of our institutional oral health research training program is designed to provide training opportunities at the PhD and post-doctoral levels for both dentist and non-dentist scientists, including training in translational and clinical research, research rigor and reproducibility, and the responsible conduct of research. This program is designed to allow trainees to develop the complex skills necessary to undertake independent and collaborative research, and thus to become oral health research scholars capable of meeting future opportunities and challenges in dental education and oral health research.

PI_NAMEs: LEVY, STEVEN M. (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Academia;Address;Advisory Committees;Area;Behavioral Sciences;Big Data;Biocompatible Materials;Biomedical Engineering;Biometry;career;Clinical;clinical investigation;cohort;college;craniofacial;Critiques;Dental;Dental caries;Dentistry;Dentists;Discipline;Doctor of Philosophy;Education;Educational process of instructing;Educational workshop;Environment;Epidemiology;experience;Faculty;faculty mentor;Fellowship;Funding;Genetic;Grant;Health Policy;Health Sciences;Immunology;improved;Inflammation;Institution;Interdisciplinary Study;International;Iowa;K-Series Research Career Programs;Leadership;leadership development;malignant mouth neoplasm;Mentors;Microbiology;microbiome;Odontogenesis;Oral;oral biology;Oral health;Outcome;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Public Health;recruit;Research;research facility;Research Personnel;Research Training;Science;Series;skills;stem cells;success;Tissue Engineering;Training;Training Programs;Translational Research;translational scientist;Universities;Update;Writing

PROJECT_TITLE: University of Iowa Institutional Training Program in Oral Health Research


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cardiovascular;Cerebrovascular;Childhood Injury;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stroke;Unintentional Childhood Injury

PHR: The proposed study will investigate cellular and molecular mechanisms of brain injury resulting from Congenital heart disease (CHD). Experiments will focus on oligodendrocyte-vascular crosstalk in normal development and how they support myelination and how they are altered in chronic hypoxemic conditions as seen in CHD to cause white matter metabolic dysfunction, maturation delay and injury

PI_NAMEs: CHAVALI, MANIDEEP  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Affect;angiogenesis;Attenuated;Autopsy;Axon;Behavioral;biomarker identification;Birth;Blood flow;Blood Vessels;Brain;Brain Injuries;brain tissue;candidate marker;Cell Communication;Cell Density;Cell Lineage;Cell Separation;Cells;Cerebral Palsy;Cerebrum;Child;Childhood stroke;Chronic;Circulation;Cognitive;conditional knockout;congenital heart abnormality;Data Set;Defect;Development;Disease;Double Outlet Right Ventricle;Electron Microscopy;Endothelial Cells;endothelial stem cell;Endothelium;experimental study;fetal;Genes;Goals;Human;human disease;Hypoxemia;Hypoxia;Image;imaging approach;Immunohistochemistry;improved;In Situ Hybridization;Infant;Injury;innovation;insight;Knockout Mice;Lead;Left;Ligands;Light;malformation;Mass Spectrum Analysis;Mentors;Mentorship;Metabolic;Metabolic dysfunction;Metabolic stress;Metabolism;Modeling;Molecular;mouse genetics;mouse model;Myelin;myelination;myocardial hypoxia;Neonatal;neonatal brain;Neonatal Brain Injury;neonatal hypoxic-ischemic brain injury;neonate;Neurocognitive;neurodevelopment;Neuroglia;neuropathology;new therapeutic target;novel;Nutrient;oligodendrocyte progenitor;Oligodendroglia;Oligonucleotides;Operative Surgical Procedures;Outcome;Oxidative Stress Pathway;Oxygen;Pathway interactions;Periventricular Leukomalacia;pharmacologic;Phase;Postdoctoral Fellow;Premature Birth;Process;programs;Proteomics;resilience;Role;Shunt Device;Signal Transduction;skills;small molecule;Specimen;Stearoyl-CoA Desaturase;stem cells;structural heart disease;Supporting Cell;Survivors;Techniques;Time;tool;Training;transcriptome sequencing;transcriptomics;Transposition of Great Vessels;United States;Up-Regulation;Vascular Endothelial Growth Factors;Vascularization;VEGFA gene;Ventricular Septal Defects;white matter;white matter injury;Work

PROJECT_TITLE: Oligo-Vascular Crosstalk in the Developing Brain: Implications For White Matter Injury In Congenital Heart Disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The idiopathic inflammatory myopathies are rare orphan disease that are hallmarked by the presence of various autoantibodies each with their own unique clinical phenotype. In this proposal, we utilize human peripheral blood mononuclear cells (PBMCs) from patients with IIM and healthy controls to understand the immune signatures and transcriptomics that drive IIM pathogenesis. We will also take the prior discovery that Jo1+ patients overexpress the redox sensor TXNIP and ascertain how TXNIP overexpression alters B cell metabolism.

PI_NAMEs: WILFONG, ERIN M (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Academic Medical Centers;Active Learning;Affect;Amino Acyl-tRNA Synthetases;analytical tool;Autoantibodies;Award;B-Lymphocytes;biobank;Bioinformatics;Biology;Biometry;career;career development;CD19 gene;Cell Physiology;Cells;Cellular Immunology;Cellular Metabolic Process;Cessation of life;Characteristics;Chemicals;Clinical;clinical phenotype;clinical training;cohort;Communication;Connective Tissue Diseases;Critical Care;Critical Illness;CXCR4 gene;Cytometry;Data;Data Set;Development;Development Plans;Disease;Doctor of Medicine;Doctor of Philosophy;Ensure;Environment;Equipment;experience;experimental study;extracellular;Fostering;Foundations;Funding;Future;Gene Expression Profile;Genetic Transcription;Goals;Heterogeneity;high dimensionality;Human;Hypersensitivity;Idiopathic Inflammatory Myopathies;Immune;Immunologics;Immunology;Immunophenotyping;in vitro Assay;Inflammatory;inhibitor;insight;instructor;Interstitial Lung Diseases;Investigation;K-Series Research Career Programs;Knowledge;Leadership;Learning;Lentivirus;longitudinal analysis;Lung;Lung Transplantation;Machine Learning;Medicine;Mentors;Mentorship;Metabolic;metabolic profile;Methodology;Molecular Immunology;monocyte;Muscle;Myositis;neuromuscular;new therapeutic target;novel;Organ;Outcome;overexpression;Oxidation-Reduction;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Peripheral Blood Mononuclear Cell;Physicians;Population;Postdoctoral Fellow;Principal Investigator;programmed cell death protein 1;programs;Pulmonology;Rare Diseases;Research Project Grants;Research Proposals;research study;Respiratory Failure;Rheumatism;Rheumatology;Sampling;Scientist;Scleroderma;sensor;Severity of illness;single-cell RNA sequencing;skills;Skin;supplemental oxygen;Syndrome;T-Lymphocyte;Techniques;Technology;Time;Training;transcriptomics;Transfection;translational immunology;translational research program;TXNIP gene;Up-Regulation

PROJECT_TITLE: Immunophenotypes in the Idiopathic Inflammatory Myopathies

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Depression leads to increased morbidity and mortality. Furthermore, patients with limited English proficiency (LEP) face additional challenges when obtaining treatment for depressive symptoms in primary care; systematic depression screening and a focus on initial treatment may help reduce these disparities in depression care. Completion of the proposed studies is expected to improve depression care for patients with LEP in primary care, by (1) evaluating implementation of depression screening and initial depression care in a large health care system, (2) examining patient-physician communication about depressive symptoms, and (3) incorporating stakeholder perspectives in the development of an intervention prototype to promote depression screening and patient-provider discussion of diagnosis and treatment preferences in routine primary care visits.

PI_NAMEs: GARCIA, MARIA ESTELI (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Address;Adoption;anti-depressive agents;Area;Asian population;Award;Behavioral;California;care delivery;career;Caring;Chinese;Chronic Disease;Clinic;Clinical;cohort;Communication;Country;Custom;Data;Decision Making;demographics;Depression screen;depressive symptoms;design;Diagnosis;disability;Disclosure;Discourse analysis;Disease Outcome;Disease remission;Disparity;disparity reduction;Education;Electronic Health Record;empowerment;Ensure;Equity;evidence base;experience;Experimental Designs;Face;follow-up;Fostering;Foundations;Funding;Future;Genetic Transcription;Goals;Health;Health Disparities Research;health disparity;Health Services;Health system;Healthcare;Healthcare Systems;implementation evaluation;implementation science;improved;Individual;Internist;Intervention;intervention refinement;Interview;K-Series Research Career Programs;Knowledge;Language;Latino;Latino Population;Limited English Proficiency;Linguistics;Mental Depression;Mental Health;Mentors;Mentorship;Methods;Morbidity - disease rate;mortality;mortality risk;National Institute on Minority Health and Health Disparities;novel;Outcome;Patient Care;patient engagement;patient oriented;patient-clinician communication;Patients;Pattern;Pharmaceutical Preparations;Phase;Physicians;Population;preference;Primary Care;primary care patient;primary care practice;primary care provider;primary care setting;primary care visit;Primary Health Care;prototype;Provider;Quality of life;Reduce health disparities;Research;Research Personnel;Research Priority;Review Literature;Risk;San Francisco;screening;shared decision making;skills;Spanish;stakeholder perspectives;Structure;Summary Reports;Surveys;System;systematic review;Testing;theories;therapy design;therapy development;tool;Training;United States

PROJECT_TITLE: Equity in Depression Care for Primary Care Patients with Language Barriers


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Cost Effectiveness Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: The goal of the proposal is to identify optimal lung cancer (LC) screening strategies for breast (BC), prostate (PC), colorectal (CRC) cancer survivors by developing and validating a novel Multi-Racial and Ethnic Lung Cancer Model (MELCAM) that will simulate LC development, progression, detection, treatment, and survival in a multiethnic cancer survivor population. We will then assess the effectiveness and cost-effectiveness (CE) of different LC screening strategies for this large group of cancer survivors (>6 million in the US). The study will be innovative in applying state-of-the-art modeling approaches to evaluate LC screening in a diverse population of cancer survivors, an understudied group at risk for poorer outcomes, and our results will have direct implications for the management of large numbers of cancer survivors and guide patient decision- making.

PI_NAMEs: KONG, CHUNG YIN ;LIN, JENNY J.;WISNIVESKY, JUAN P (contact)

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: Age;Biochemical;Breast;Calibration;cancer diagnosis;Cancer Etiology;Cancer Model;Cancer Survivor;Clinical Trials;cohort;Colorectal;Colorectal Cancer;colorectal cancer screening;comorbidity;cost effectiveness;Data;Decision Making;Detection;Development;Diagnosis;Disease;effectiveness evaluation;Eligibility Determination;ethnic diversity;Ethnic Origin;Exclusion;Female;Frequencies;General Population;Goals;Health Care Costs;high risk;human old age (65+);innovation;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;men;Methods;Modeling;models and simulation;mortality;mortality risk;multi-ethnic;multi-racial;novel;Outcome;Patient-Focused Outcomes;Patients;Population;population based;Population Heterogeneity;Populations at Risk;Preventive service;Prostate;Quality of life;Race;racial diversity;Radiation therapy;randomized trial;Recommendation;Recording of previous events;Recurrence;Regimen;Risk;screening;Screening for cancer;screening guidelines;Second Primary Cancers;sex;Smoking;Smoking History;Survivors;survivorship;Time;tobacco exposure;Tobacco use;Treatment Side Effects;United States;Woman

PROJECT_TITLE: Optimizing Lung Cancer Screening in Cancer Survivors

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative  Hundreds of millions of dollars have been spent on collecting human neuroimaging data for clinical and re- search studies, many of which do not come with subject consent for sharing or contain sensitive data which are not easily shared, such as genetics. Open sharing of raw data, though desirable from the research perspective, and growing rapidly, is not a viable solution for a large number of datasets which have additional privacy risks or IRB concerns. The COINSTAC solution we propose enables us to capture this `missing data' and achieve the same performance as pooling of both open and `closed' repositories by developing privacy preserving versions of advanced and cutting edge algorithms (including linear mixed effects models and deep learning) and incorpo- rating within an easy-to-use and scalable platform which enables distributed computation. 2

PI_NAMEs: CALHOUN, VINCE D (contact);PLIS, SERGEY

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: addiction;Address;Adoption;Affect;Agreement;Alcohols;Algorithms;Atlases;Awareness;base;Brain;Brain imaging;Cannabis;Classification;Clinical Data;Clinical Research;cloud based;Cocaine;Communities;community engagement;computational platform;computerized data processing;computerized tools;computing resources;Consent;Consent Forms;Coupled;Data;Data Aggregation;data harmonization;Data Pooling;data repository;data reuse;Data Set;data sharing;data visualization;Decentralization;deep learning;Development;distributed data;Environment;Family;forgetting;Funding;Genetic;Genomics;Human;improved;Individual;Informatics;Institution;Institutional Review Boards;International;Knowledge;Language;large datasets;Learning;learning algorithm;Legal;life-long learning;Link;Location;Machine Learning;Maps;Measures;Methamphetamine;Modeling;Movement;neuroimaging;Neurosciences;Nicotine;novel;novel strategies;open data;open source;Opioid;peer;Performance;Phase;Population;Positioning Attribute;pre-trained model;Privacy;privacy preservation;Privatization;Process;Public Health;Quality Control;repository;Reproducibility;Research;Research Personnel;research study;Resources;Risk;Running;scale up;Science;Security;Series;Site;Source;Source Code;Statistical Bias;Structure;Substance of Abuse;substance use;success;supervised learning;System;Testing;Time;tool;Training;United States National Institutes of Health;unsupervised learning;Update;usability;virtual;Visualization;Work

PROJECT_TITLE: COINSTAC 2.0: decentralized, scalable analysis of loosely coupled data

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: DETROIT

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Black adolescents with type 1 diabetes (T1D) face disparities in health outcomes, such as higher risk for elevated blood glucose levels, which can lead to diabetes complications. The proposed study will test a brief, family intervention delivered through mobile health technology intended to optimize family interactions related to diabetes care. If successful, the intervention has the potential to improve health outcomes in a vulnerable population of youth as well as the health of their primary caregivers.

PI_NAMEs: ELLIS, DEBORAH A. (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: 15 year old;Adolescence;Adolescent;adolescent health;Affect;Anxiety;Area;attentional control;Behavior;behavior change;behavior test;Behavior Therapy;behavioral health;behavioral health intervention;Black race;Blood Glucose;Buffers;Caregivers;Caring;Child Rearing;Clinic;Clinic Visits;clinical research site;Clinical Trials;Collaborations;community advisory board;Complications of Diabetes Mellitus;Computer software;Conflict (Psychology);Cost Analysis;cost effectiveness;design;Development;diabetes distress;diabetes management;Diabetes Mellitus;Disparity;disparity reduction;Distress;Dose;efficacy evaluation;efficacy testing;eHealth;Equity;Evaluation;experience;Face;Family;Family health status;Family member;Family Relationship;follow-up;glycemic control;Health;health disparity;Health Technology;Healthcare;high risk;Hospitalization;improved;independent self care;Individual;Insulin-Dependent Diabetes Mellitus;Intervention;intervention cost;intervention refinement;Intervention Trial;Interview;Literature;Mental Depression;Mental Health;mHealth;mhealth interventions;Modeling;Motivation;Multi-Institutional Clinical Trial;Multicenter Trials;Neighborhoods;Outcome;parental monitoring;Parents;Personal Satisfaction;Phase;Play;poor health outcome;primary caregiver;primary endpoint;protective factors;Racial Segregation;racism;randomized, clinical trials;Randomized, Controlled Trials;Recording of previous events;recruit;Reporting;Research;Research Support;resilience;Risk;Risk Factors;Role;Sampling;secondary endpoint;social;Stress;stressor;Tablet Computer;Testing;therapy design;Time;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Family mHealth Intervention to Improve Health Outcomes in Black Youth with Type 1 Diabetes: A Multi-Center Randomized Controlled Trial

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE  Cancer immunotherapies have achieved impressive clinical outcomes in a small subset of cancer patients. We will develop a novel therapeutic agent that can boost cancer immunotherapies. We expect that successful completion of this project will make a significant impact on cancer treatments.

PI_NAMEs: WANG, JIN  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Accounting;Advanced Malignant Neoplasm;anti-PD-1;Antigens;Biological Assay;Biology;biomarker identification;cancer cell;Cancer cell line;cancer immunotherapy;Cancer Patient;cancer therapy;Canis familiaris;Cell Survival;Cells;Chemicals;Clinical;clinical translation;Complex;congenital immunodeficiency;Development;Dose;Drug Exposure;efficacy evaluation;Future;Genetic study;gut inflammation;Half-Life;Human;humanized mouse;Immune;immune checkpoint blockade;Immune system;Immunocompetent;Immunophenotyping;Immunotherapy;improved;in vivo;Individual;Induction of Apoptosis;Inflammatory;inhibitor;innate immune pathways;innovation;Interferons;Intervention;Investigation;Knock-out;Ligands;loss of function;Melanoma;meter;Modeling;Monkeys;Monoclonal Antibodies;mouse model;multiple omics;Mus;Mutation;novel therapeutics;Oral;Outcome;Pathway interactions;patient response;patient stratification;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology and Toxicology;Phenocopy;Phenotype;Phosphotransferases;Plasma;potential biomarker;Pre-Clinical Model;Property;Protac;Protein Kinase Interaction;Proteins;Proteome;Proteomics;Rattus;Receptor-Interacting Protein;recruit;Research;response;Scaffolding Protein;Signal Transduction;species difference;Specificity;success;Symptoms;synergism;T-Cell Activation;Technology;Testing;Therapeutic;Therapeutic Agents;TNF gene;Toll-like receptors;transcriptome;Transgenic Mice;Transgenic Organisms;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Immunity;tumor initiation;tumor microenvironment;Variant;Work

PROJECT_TITLE: Development of First-in-Class RIPK1 Degraders to Improve Cancer Immunotherapies

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRARTIVE California law now mandates that as of January 1, 2019, all eligible Medicaid beneficiaries with prediabetes must have the opportunity to enroll in the Diabetes Prevention Program. We plan to study this law as a natural experiment, analyzing whether the law will result in weight loss and other desired clinical outcomes for Medicaid patients. We also plan to study on-the-ground perspectives of DPP suppliers, lifestyle coaches, and Medicaid patients that will ultimately determine the success of this legislation.

PI_NAMEs: DURU, OBIDIUGWU KENRIK (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Adult;advanced analytics;Affect;American;Amputation;Awareness;beneficiary;Blindness;Blood Pressure;Body Weight;Body Weight decreased;California;Cardiovascular Diseases;Centers for Disease Control and Prevention (U.S.);Clinical;clinical outcome measures;cohort;Communities;Contracts;cost;Cost Analysis;Cost Savings;Data;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;Economic Burden;Effectiveness;effectiveness evaluation;Eligibility Determination;eligible participant;Enrollment;Evaluation;Evaluation Research;experience;Funding;Future;Goals;Health;Health Insurance;health plan;Health Services;Health Services Research;Health system;implementation barriers;insight;Insurance Coverage;Interview;Kidney Failure;Laws;Life Style;Los Angeles;Low income;Lower Extremity;Medicaid;Medicaid eligibility;Medical;Medical Care Costs;Middle Class Populations;Minority;multidisciplinary;Natural experiment;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Outcomes Research;Participant;participant retention;patient engagement;patient population;Patients;Persons;Phase;Policies;Policy Analysis;policy implication;Policy Maker;Population;Positioning Attribute;Prediabetes syndrome;prevent;primary outcome;Process;Productivity;Program Evaluation;programs;Qualitative Methods;recruit;Research;Research Personnel;secondary outcome;Statutes and Laws;Structure;success;Target Populations;Techniques;United States;Universities;uptake

PROJECT_TITLE: A Multi-Level Evaluation of California's New Medicaid Coverage for the Diabetes Prevention Program


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE We will address key gaps in mechanistic understanding of protein ubiquitylation machinery, with special focus on questions regarding how different ubiquitylated products are determined. Under- and uncharacterized members of the human E2 and RBR E3 families along with their bona fide substrates will be investigated using a range of structural, biochemical, biophysical, and cellular strategies.

PI_NAMEs: KLEVIT, RACHEL E (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Affect;BARD1 gene;Biochemical;Biochemical Reaction;Biophysics;BRCA1 gene;cell growth regulation;Cell Physiology;Cells;Data;Development;DNA Damage;Enzymes;Family;Functional disorder;Genetic Transcription;Human;human disease;Human Genome;insight;Knowledge;Lysine;Malignant Breast Neoplasm;member;Modification;Process;Protein Engineering;protein function;Proteins;Reaction;Research;response;Site;stem;Structure;System;therapeutic target;Translations;Tumor Suppressor Proteins;Ubiquitin;ubiquitin-protein ligase;Work

PROJECT_TITLE: Expanding Mechanistic Insights into Protein Ubiquitylation

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Telehealth

ORG_CITY: PROVIDENCE

ORG_DEPT: PSYCHIATRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE  This study aligns with NIMH strategic priorities and will strengthen the public health impact of NIMH- supported research by leveraging low-cost technology to improve the efficiency, effectiveness, and scalability of evidence-based mental health services in Sierra Leone. Study aims will investigate the innovative use of mobile phone-based supervision and fidelity monitoring to support mental health services delivery quality within the education sector. Study results have the potential to galvanize political and improve adoption and sustainment of evidence-based mental health services within the education sector and other alternative delivery settings able to reach vulnerable youth in LMICs and other low resource regions.

PI_NAMEs: DESROSIERS, ALETHEA  (contact)

PROGRAM_OFFICER_NAME: BEKALU, MESFIN AWOKE

PROJECT_TERMS: Address;Adolescent;Adoption;Adult;Africa;aged;Behavior;Behavioral;behavioral health;burden of illness;Cellular Phone;Clinical effectiveness;Cluster randomized trial;Cognitive Therapy;Communication;compare effectiveness;cost;cost effective;cost effectiveness;cost-effectiveness ratio;daily functioning;Data;data dashboard;design;disability-adjusted life years;Education;educational atmosphere;Educational Status;Effectiveness;Effectiveness of Interventions;effectiveness/implementation design;emotion regulation;Emotional;Employment;Enrollment;Evaluation;evidence base;Exhibits;Exploration, Preparation, Implementation, and Sustainment;Face;Family;Government;Government Officials;Health;Health Benefit;health care delivery;Hybrids;Image;implementation facilitators;implementation intervention;implementation science;implementation strategy;implementation/effectiveness;improved;incremental cost-effectiveness;Infrastructure;innovation;Intervention;intervention delivery;Investments;low and middle-income countries;Mental disorders;Mental Health;Mental Health Services;Methods;mHealth;Mobile Health Application;Modeling;Monitor;National Institute of Mental Health;organizational climate;Outcome;Persons;Pilot Projects;Politics;Population;Preparation;Prevalence;Professional counselor;programs;promote resilience;Public Health;Readiness;Recording of previous events;relative cost;Research;Research Support;Resource-limited setting;Resources;Risk Factors;scale up;Schools;secondary outcome;Secondary Schools;Services;Sierra Leone;Students;Substance Use Disorder;Supervision;teacher;Technology;Time;tool;Training;Training and Education;Training Programs;Training Support;trial design;user centered design;video chat;Violence;Voice;Widespread Disease;willingness to pay;Youth

PROJECT_TITLE: Advancing mHealth-supported Adoption and Sustainment of an Evidence-based Mental Health Intervention for Youth in a School-based Delivery Setting in Sierra Leone

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Estrogen;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: DAVIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: The proposed research is relevant to public health because defects in germline mechanisms are  responsible for various genetic and epigenetic diseases. This study has high potential  to identify novel epigenetic mechanisms that govern distinct sexually dimorphic processes  in spermatogenesis and oogenesis. The outcome of this study will contribute to significant,  transformative advances in germline biology, and to our understanding of human reproduction and  reproductive health.

PI_NAMEs: NAMEKAWA, SATOSHI  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Address;Biology;Complement;Complex;Defect;Development;Developmental Process;Disease;DNA Damage;egg;Embryo;Ensure;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Female;Foundations;Gene Expression;Gene Expression Regulation;Generations;Genetic;Genome;Germ Cells;Germ Lines;Global Change;Human;innovation;Life;Maintenance;male;Meiosis;Mitosis;Molecular;next generation;novel;oocyte maturation;Oogenesis;Outcome Study;Pathway interactions;Positioning Attribute;postnatal;Process;Production;programs;Public Health;Reproduction;Reproductive Health;Research;response;Sex Chromosomes;sexual dimorphism;sperm cell;Spermatocytes;Spermatogenesis;stem cells;therapy development;Work

PROJECT_TITLE: Epigenetic gene regulation in the germline

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Regenerative Medicine

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The objective of the Cell and Tissue Engineering training program is to provide innovative and integrated training for predoctoral engineering students in cell and tissue engineering to develop future leaders for these biotechnology industries.

PI_NAMEs: BOTCHWEY, EDWARD A.;GARCIA, ANDRES J (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: cellular engineering;Tissue Engineering;Training Programs

PROJECT_TITLE: T32 CTEng (Cellular and Tissue Engineering) Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: IRVINE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative (Relevance to Public Health) The proposed work tests whether differences in infant morbidity and death among non-Hispanic Black and non-Hispanic white preterm births arise due to strong disparities in fetal death rates. Our project will also use a structural racism framework to document racial/ethnic differences in both preterm and infant mortality rates across place and time, in response to selection in utero, medical advances in neonatal care, and several features of structural racism. We expect that results will identify, among the high-risk group of preterm births, specific drivers of racial/ethnic differences in infant survival that may respond to intervention efforts.

PI_NAMEs: BRUCKNER, TIM ALLEN (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: 37 weeks gestation;Affect;antenatal;Area;Birth;Birth Rate;Black Populations;Black race;black/white disparity;Childhood;Clinical;clinical practice;cohort;Conceptions;County;Data;Death Rate;Death Records;Developmental Delay Disorders;developmental disease;Disparity;disparity reduction;Education;ethnic difference;Ethnic Origin;fetal;Fetal Death;fetal loss;Fetus;fetus at risk;Gestational Age;Health;health care availability;health care disparity;health disparity;Healthcare;high risk population;High-Risk Pregnancy;Hospitalization;Imprisonment;improved;in utero;Inequality;Infant;Infant Health;infant morbidity;infant morbidity/mortality;Infant Mortality;innovation;Intervention;Knowledge;knowledge base;Link;Live Birth;Measures;Medical;Methods;Morbidity - disease rate;Mothers;National Institute of Child Health and Human Development;neglect;Neonatal;neonatal care;Not Hispanic or Latino;Outcome;Pattern;Perinatal;perinatal health;perinatal outcomes;Pregnancy;Premature Birth;Premature Infant;Public Health;Quality of Care;Race;racial difference;racial disparity;Records;Research;Research Priority;Resource Allocation;Resources;response;Risk;Sampling;segregation;Steroids;Stress;structural determinants;Structural Racism;Survivors;Technology;Testing;Time;trend;Variant;Work

PROJECT_TITLE: Racial disparities in preterm births and fetal losses

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative Dr. Lichterfeld is an infectious disease physician whose research program bridges clinical, translational and basic science research studies for finding a cure for HIV-1 infection, and emphasize direct patient involvement and participation in research projects. In this K24 application, he proposes to expand his mentoring activities to train physicians and scientists in the design and conduct of clinical trials aiming for HIV-1 eradication, in studies to profile HIV-1 reservoir cells using novel technologies, and in investigations related to pediatric HIV-1 infection.

PI_NAMEs: LICHTERFELD, MATHIAS  (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: Address;Adherence;Adult;Antigens;antiretroviral therapy;Area;Basic Science;biocomputing;Bioinformatics;Biological Assay;Birth;Botswana;bridge program;career;Cells;Cellular Immunology;Characteristics;Childhood;Chromatin;chromatin immunoprecipitation;Clinic;Clinical;clinical care;Clinical Medicine;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Design;Collaborations;Communicable Diseases;Communities;Complex;Conduct Clinical Trials;Consensus;Creativeness;design;Development;Disease;Disease remission;Doctor of Philosophy;Educational workshop;Epigenetic Process;Evolution;experience;Faculty;Funding;Future;General Hospitals;Genetic;Genetic Transcription;Genome;genome analysis;global health;HIV;HIV-1;Home;Hospitals;Hour;Human;Immune response;Immune system;Immunologics;improved;Individual;Infant;infant infection;Infection;innovation;Institution;integration site;interest;Interruption;Intervention;Intervention Studies;Investigation;Investments;Knowledge;Knowledge acquisition;Laboratory Research;Length;Life;Life Expectancy;Massachusetts;member;Mentors;Mentorship;Molecular;Molecular Immunology;Monitor;multidimensional data;National Institute of Allergy and Infectious Disease;Neonatal;neonatal infection;neonate;neutralizing antibody;new technology;next generation;next generation sequencing;novel;novel therapeutic intervention;patient oriented;patient oriented research;patient population;Patients;pediatric human immunodeficiency virus;Persons;Pharmaceutical Preparations;Physicians;Positioning Attribute;Predisposition;Principal Investigator;Procedures;programs;Proteomics;protocol development;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;research study;Residual state;Resources;Retrovirology;Sampling;Scientist;skills;Subgroup;Systems Biology;Techniques;Technology;Therapeutic Intervention;therapy development;Time;Training;training opportunity;Training Programs;Translating;Translational Research;United States National Institutes of Health;Universities;Viral;Viral Load result;Viral reservoir;Virus Diseases;Virus Integration;Woman;Work

PROJECT_TITLE: Mentoring in patient-oriented research to finding a cure for HIV-1 infection

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Genes work in groups to dictate the properties and behaviors of bacteria, but which genes work together and how they work is often unknown. To address these issues, we propose to study groups of genes and ask about how they function together across multiple species of bacteria. Gene groups that function similarly across species may reveal fundamental features of bacterial life and potentially serve as future antibiotic targets.

PI_NAMEs: PETERS, JASON M. (contact)

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotics;Bacteria;Bacterial Genes;Bacterial Physiology;Basic Science;Beds;Behavior;biological adaptation to stress;Chemicals;CRISPR/Cas technology;Enteral;Enterobacter cloacae;Escherichia coli;Future;Gene Expression Regulation;gene function;gene network;Genes;Genetic;genome-wide;Health;Homeostasis;host-microbe interactions;Human;Human Microbiome;Klebsiella pneumoniae;Life;Microbe;pathogenic bacteria;Pathway interactions;Pattern;portability;promoter;Property;Regulon;Role;Stress;Study models;Testing;Work

PROJECT_TITLE: Cross-species Analysis of Bacterial Gene Networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Radiation Oncology;Rare Diseases

ORG_CITY: Alameda

ORG_NAME: MAGNETIC INSIGHT, INC.

PHR: NARRATIVE Magnetic Particle Imaging (MPI) is an emerging imaging technology that directly quantitates magnetic nanoparticle (MNP) concentration in tissue, while Magnetic Fluid Hyperthermia (MFH) can activate those same MNPs, causing local tissue heating and killing of tumor cells. In this grant, we will advance MFH by building the first clinical-scale localized MFH system, incorporating realtime MPI tomographic temperature monitoring to enable thermal dosimetry in the target during treatment. Successful completion of the objectives will provide a system ready for future large animal and clinical trial testing.

PI_NAMEs: GOODWILL, PATRICK  (contact)

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: 3-Dimensional;Abscopal effect;Animals;Applications Grants;Area;attenuation;Brain Neoplasms;brain size;Cadaver;Cancer Model;cancer therapy;Canis familiaris;Cell Death;chemotherapy;Clinical;clinical imaging;Clinical Research;Clinical Treatment;Clinical Trials;commercialization;Computer software;cytotoxic;Data;design;Development;Devices;Diagnostic Imaging;Dose;dosimetry;Effectiveness;Engineering;Europe;European;experience;Feedback;Future;Glioblastoma;Goals;Grant;Head;Heating;Human;hyperthermia treatment;Image;image guided;imager;imaging system;Imaging technology;Immune response;immunogenic cell death;Immunologic Stimulation;In Vitro;in vivo;in vivo Model;innovation;insight;Intensity-Modulated Radiotherapy;interest;Lesion;magnetic field;Magnetic fluid hyperthermia;Magnetic nanoparticles;Magnetism;Malignant neoplasm of prostate;Measurement;Measures;millimeter;Modeling;Monitor;nanoparticle;neoplastic cell;new technology;Normal tissue morphology;Oils;particle;Penetration;Performance;Phase;pre-clinical;preclinical trial;Preparation;prototype;quality assurance;Radiation therapy;Radio;Recurrence;Resolution;Scanning;Shapes;Signal Transduction;Small Business Innovation Research Grant;System;Technology;Temperature;Temperature Sense;Testing;theranostics;Therapeutic;Therapeutic Effect;Time;time use;Tissues;tomography;treatment planning;tumor;Universities;Visualization;Water;Width;Work

PROJECT_TITLE: Development of a prototype clinical theranostic platform combining Magnetic Particle Imaging (MPI) and Magnetic Fluid Hyperthermia (MFH) for the treatment of brain tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-E(11)B]


ORG_CITY: PHILADELPHIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative: Accurate reprogramming of the mammalian genome is essential for the production of mature eggs and sperm and viability of offspring. Failures in reprogramming can lead to infertility, developmental disorders and imprinting syndromes.

PI_NAMEs: BARTOLOMEI, MARISA S. (contact)

PROJECT_TERMS: Address;Adult;Aging;Alleles;base;Base Excision Repairs;bead chip;Behavioral Assay;Biological Assay;Brain;Cell Reprogramming;Chromatin;chromatin protein;Coupled;Data;demethylation;Development;developmental disease;Disease;DNA;DNA biosynthesis;DNA Methylation;DNA Modification Methylases;DNA Modification Process;egg;Embryo;Engineering;Ensure;Enzymes;Epigenetic Process;epigenome;epigenomics;Excision;Failure;Family;Fertilization;fetal;Fibroblasts;Generations;Genes;Genetic;Genetic Transcription;Genome;genome-wide;genomic locus;Genomics;Germ Cells;Germ Lines;Gonadal structure;Heterogeneity;histone modification;imprint;in vivo;induced pluripotent stem cell;Infertility;Link;Maintenance;mammalian genome;Mediating;Meiosis;Methylation;methylation pattern;migration;mouse genome;Mouse Strains;Mus;mutant;Mutant Strains Mice;Mutation;neurobehavior;new technology;next generation;offspring;Oocytes;oxidation;Partner in relationship;Pathway interactions;Pattern;Phenotype;Play;prevent;Production;Publishing;pup;response;Role;sexual dimorphism;Shapes;Somatic Cell;sperm cell;Structure of primordial sex cell;Syndrome;Technology;Testing;Tissues;tool;transcriptome sequencing;transmission process;Wild Type Mouse;Work

PROJECT_TITLE: Role of TET1 in germ cell reprogramming and development

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine;Rehabilitation

ORG_CITY: CHAPEL HILL

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE  Parkinson disease is the second most common degenerative disease of the brain, affecting over 6 million people worldwide, and a rapidly growing cause of disability. Deep brain stimulation (DBS) is effective for treating many of the most disabling symptoms of Parkinson disease, however predicting the improvement received from DBS remains challenging. Our study will improve the care of those with Parkinson disease by developing a robust method using MRI to predict those who will benefit most from DBS.

PI_NAMEs: YOUNCE, JOHN ROBERT (contact)

PROGRAM_OFFICER_NAME: CHO, HYUN JOO

PROJECT_TERMS: adverse outcome;Affect;Anterior;Area;Award;Behavioral;Brain Diseases;Caring;Cerebellum;Clinical;Clinical Data;Clinical Research;clinically relevant;Cognitive;cohort;common symptom;Data;Data Sources;Deep Brain Stimulation;Degenerative Disorder;Dementia;demographics;Diffusion;disability;disabling symptom;Disease;Dopa;Environment;Ethics;Evaluation;experience;feature selection;Functional Magnetic Resonance Imaging;Funding;Future;Globus Pallidus;Goals;Image;improved;improved outcome;Individual;Institution;Intervention Studies;K-Series Research Career Programs;Lateral;Levodopa;Link;Magnetic Resonance Imaging;Measures;Medical;Mentors;Mentorship;Methods;model development;Modeling;Moods;Motor;Motor Cortex;motor symptom;Multimodal Imaging;multimodality;Nervous System Disorder;Neurobehavioral Manifestations;neuroimaging;Neuropsychology;neuroregulation;novel;Occipital lobe;Operative Surgical Procedures;Outcome;outcome prediction;Parkinson Disease;Participant;patient oriented;Patient Selection;Patients;Persons;Predictive Factor;predictive modeling;predictive tools;Prefrontal Cortex;programs;prospective;Prospective cohort;recruit;Research;Research Design;Research Personnel;response;Rest;Retrospective cohort;Scientist;Short-Term Memory;side effect;skills;Source;Statistical Data Interpretation;Statistical Models;STN stimulation;Structure of subthalamic nucleus;supervised learning;Techniques;Testing;Thalamic structure;Thick;tool;Training;Training Support;treatment optimization;Validation;Ventricular

PROJECT_TITLE: Prediction of outcomes for deep brain stimulation using multimodal MRI

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Nutrition;Obesity;Physical Activity;Prevention;Telehealth

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PUBLIC HEALTH RELEVANCE STATEMENT The overall aim of this project is to determine the effectiveness of Acceptance and Commitment Therapy telephone coaching for weight loss. If successful, this intervention can be cost-effectively scaled on a population level, thereby making a high public health impact.

PI_NAMEs: BRICKER, JONATHAN B (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: active method;Address;Adult;Age;Anxiety;Behavior;Behavior Therapy;Behavioral;Behavioral Paradigm;Body mass index;Body Weight Changes;Body Weight decreased;Calories;comparative effectiveness;cost;craving;Cues;design;Diabetes Mellitus;dietary;Dietary intake;Disinhibition;Eating;Education;effectiveness evaluation;Emotions;Employee;Ethnic Origin;experience;follow-up;Food;food craving;Geography;good diet;group intervention;Health;health disparity;Healthcare;Healthcare Systems;Heart Diseases;Hyperphagia;Individual;individualized feedback;Intervention;Low income;Malignant Neoplasms;Mediating;Medical Care Costs;men;Mental Depression;mindfulness;Minority;Modality;Motivation;Obesity;Operative Surgical Procedures;Outcome;Overweight;Participant;Persons;pharmacologic;Physical activity;Population;primary care clinic;Privatization;Process;programs;Protocols documentation;psychologic;Public Health;public health relevance;Race;Randomized;randomized effectiveness trial;Randomized, Controlled Trials;Research;response;Sample Size;Science;secondary outcome;sedentary lifestyle;sex;social stigma;Stress;Subgroup;success;Telephone;telephone coaching;telephone delivery;Testing;Therapeutic Intervention;Thinking;Time;Training;Weight;weight loss intervention;Wellness Program;willingness;Work

PROJECT_TITLE: Telephone Delivered Acceptance & Commitment Therapy for Weight Loss

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Current therapies that reinvigorate immune cells, such as checkpoint blockade, have revolutionized cancer patient treatment; however, not all patients respond to these therapies, highlighting the necessity to understand the biology of immune cells that reside in tumors. This proposal seeks to understand the biology of cytotoxic killer T cells in cancer by focusing on an enzyme family called E3 ubiquitin ligases that are not expressed when T cells become dysfunctional in tumors, but when we engineer T cells to express these ligases, the T cells can control tumor growth in mice. By understanding how these enzymes help T cells function in tumors, we can improve cancer therapy and improve cancer patient outcomes.

PI_NAMEs: GOLDRATH, ANANDA W (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Acute;Antigens;Biological;Biological Assay;Biological Process;Biology;Biotin;cancer immunotherapy;Cancer Model;Cancer Patient;cancer therapy;Cancerous;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;Cell Physiology;Cell Surface Receptors;Cells;Cellular biology;Characteristics;chimeric antigen receptor T cells;Chronic;CRISPR/Cas technology;cytokine;Cytosol;cytotoxic;Cytotoxic T-Lymphocytes;Data;differential expression;Disease;Doxycycline;engineered T cells;Enzymes;Epigenetic Process;exhaust;exhaustion;Family;Genes;Genetic Transcription;high reward;high risk;Homeostasis;Immune;immune checkpoint blockade;Immunotherapy;improved;In Vitro;in vivo;Infection;Inflammatory;insight;Knock-out;Label;Ligase;loss of function;Lymphocyte Function;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;member;Memory;Metabolic;misfolded protein;mouse model;multicatalytic endopeptidase complex;Mus;neoplastic cell;Patient-Focused Outcomes;Patients;Play;Population;Process;progenitor;protein degradation;Protein Engineering;protein transport;Proteins;proteostasis;receptor expression;Regulation;Resistance;response;Role;stem cell differentiation;Surveys;System;T cell differentiation;T memory cell;T-Lymphocyte;Therapeutic;tissue resident memory T cell;Tissues;transcription factor;tumor;tumor growth;tumor microenvironment;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Virus Diseases

PROJECT_TITLE: Ubiquitin ligase regulation of tissue-resident T cell and anti-tumor activity

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: The proposed research will determine the molecular mechanisms by which bacteria transport scarce nutrients across their cell membrane. This transport is critical to the functioning of the human microbiome, and it is essential for the success of many bacterial pathogens, such as the bacteria that cause meningitis, cholera and pertussis. Knowledge of these transport mechanisms will assist with the development of new antibiotics to treat bacterial infection.

PI_NAMEs: CAFISO, DAVID S (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Active Biological Transport;Affinity;Antibiotics;Apoptosis;ATP Synthesis Pathway;Automobile Driving;Bacteria;Bacterial Infections;Behavior;Binding;biophysical analysis;biophysical properties;Carbohydrates;Carrier Proteins;Cell membrane;Cell Physiology;Cells;Cholera;Coupling;Crystallography;Data;Development;Dysentery;Electron Spin Resonance Spectroscopy;Electrons;Environment;Equilibrium;Escherichia coli;experimental study;extracellular;Funding;Gram-Negative Bacteria;Human Microbiome;Hydrophobicity;In Vitro;in vivo;intermolecular interaction;Ions;Iron;Iron Chelating Agents;Iron Chelation;Island;Knowledge;Length;Lipids;Lipopolysaccharides;Measurement;Mediating;Membrane;Membrane Proteins;Meningitis;Modeling;Molecular;Molecular Conformation;molecular modeling;Motion;Movement;Nickel;novel antibiotic class;novel strategies;Nutrient;Osmosis;pathogen;pathogenic bacteria;Pertussis;Phospholipids;Physiologic pulse;Play;Preparation;Procedures;protein function;protein oligomer;protein protein interaction;protein structure;Proteins;Proton-Motive Force;reconstitution;Regulation;Research;Resolution;restraint;Role;Sampling;Site;Spin Labels;Structure;success;System;Testing;Transmembrane Transport;uptake;Vitamin B 12;Work

PROJECT_TITLE: Molecular Mechanisms of Membrane Transport

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE We previously identified CD99 as a cell surface marker frequently expressed in acute myeloid leukemia (AML) and demonstrated that it can be used to both enrich for, and therapeutically target, functionally defined LSCs in xenograft models. Our more recent studies indicate that CD99 regulates protein synthesis in LSCs and that specific mRNA transcripts are likely preferentially translated in LSCs. This proposal seeks to investigate the role of translational reprogramming by CD99 in LSCs and leverage these insights to identify novel regulators of LSCs as well as therapeutic strategies that target global and selective protein synthesis.

PI_NAMEs: PARK, CHRISTOPHER Y (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;Adult Acute Myeloblastic Leukemia;Affect;Antigens;Biological Assay;Biology;Blast Cell;cancer stem cell;CD34 gene;CD47 gene;Cell Death Induction;Cell surface;Cells;chemotherapy;Clinical;Complement;computational pipelines;Credentialing;curative treatments;cytotoxic;cytotoxicity;Data;Defect;Diagnosis;Disease;Effector Cell;Exhibits;experimental study;FRAP1 gene;Gene Expression;Genes;Genetic;Growth;Hematopoiesis;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Human;Immune;Impairment;improved;In Vitro;in vivo;Informal Social Control;inhibitor;insight;Intervention;knock-down;Knockout Mice;leukemia;leukemia initiating cell;leukemic stem cell;Messenger RNA;Methods;Modeling;Molecular;Monoclonal Antibodies;mRNA Translation;mTOR Inhibitor;novel;novel strategies;novel therapeutic intervention;Outcome;Pathway interactions;Patients;Play;Polyribosomes;polysome profiling;Population;Positioning Attribute;Process;programs;prospective;Protein Biosynthesis;Protein Synthesis Inhibition;Proteins;Publishing;Reagent;recruit;Regulation;Relapse;Residual Neoplasm;Residual state;Resistance;Ribosomal Proteins;Ribosomes;Role;Sampling;self-renewal;Signal Transduction;Signaling Molecule;Sirolimus;src-Family Kinases;stem cell biomarkers;stem cell function;stem cell self renewal;stemness;Testing;Therapeutic;therapeutic target;tool;Transcript;transcriptome sequencing;Translating;translational impact;Translational Regulation;Translational Repression;Translations;treatment response;Up-Regulation;Work;Xenograft Model

PROJECT_TITLE: Translational Control of Leukemia Stem Cells - Resubmission - 1

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE This work represents novel computational developments, improvements and applications that leverage inked-read sequencing technologies, which can more completely characterize metagenome DNA sequences. We also plan to build robust benchmarks and show the applicability of our algorithms to complex and low-abundance samples and pioneer a new approach to Precision Metagenomics.

PI_NAMEs: HAJIRASOULIHA, IMAN  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Algorithms;Bar Codes;Benchmarking;Biological Assay;Chromium;Classification;Clinical;Clinical Research;clinically relevant;Collaborations;Communities;Complex;computerized tools;Computing Methodologies;cost;Data Set;Detection;Development;DNA Sequence;DNA sequencing;Ensure;Genes;Genomics;Health;high standard;Human;improved;Industrialization;Ink;innovation;Laboratories;large scale data;Link;metagenome;Metagenomics;Methods;Microbe;microbiome;microbiome research;Molecular;nanopore;next generation sequencing;novel;novel strategies;Operative Surgical Procedures;Organism;Pathogenicity;Pathology;Pilot Projects;Reagent;Recovery;Research;resident commensals;Sampling;Shotguns;Special Hospitals;System;Techniques;Technology;whole genome;Work

PROJECT_TITLE: Improving metagenomic analysis with novel algorithms and technologies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Kidney Disease;Organ Transplantation;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Transplantation

ORG_CITY: CHARLESTON

ORG_DEPT: SURGERY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Due to a number of issues, African American kidney transplant recipients have twice the risk of graft loss as compared to Caucasians. We have completed research that identifies the main causes of this disparity and promising solutions. This study aims to test, through a 2-year, large-scale, randomized clinical trial, the use of a multidisciplinary, multimodal intervention that leverages the use mobile health, telehealth, and biomedical informatics to streamline the long-term monitoring and management of this high-risk population with the ultimate goal of reducing health disparities in African American kidney transplant recipients.

PI_NAMEs: TABER, DAVID J. (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acute;Address;Adherence;African American;arm;biomedical informatics;Blood Glucose;blood glucose regulation;Blood Pressure;blood pressure control;Caring;Caucasians;Cessation of life;Clinical;Clinical Markers;Clinical Trials;cohort;comorbidity;comparison control;Competence;cost;Cost Savings;Cost-Benefit Analysis;Coupled;Data;design;diabetes control;Diabetes Mellitus;Disparity;disparity reduction;Dropout;economic evaluation;Emergency department visit;Event;Goals;Graft Survival;health care service utilization;health disparity;health outcome disparity;Health Services;Health Services Accessibility;high risk population;hospital readmission;Hospitalization;Hypertension;hypertension control;Immunologics;Immunosuppression;Improve Access;improved;Incidence;Intervention;Investments;Kidney;Kidney Transplantation;Measures;medication compliance;Medication Management;medication nonadherence;Methods;mHealth;mhealth interventions;Mobile Health Application;Modeling;Monitor;motivational enhancement therapy;multi-component intervention;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;organ allocation;Outcome;outcome disparities;Participant;Patients;Pharmaceutical Preparations;Pharmacists;Pilot Projects;Policies;Population;post-transplant;prevent;prospective;Public Health;Public Health Informatics;racial bias;racial disparity;racial health disparity;Randomized;Randomized Controlled Clinical Trials;randomized, clinical trials;Randomized, Controlled Trials;Reduce health disparities;remote patient monitoring;Research;Risk;Self Determination;service intervention;stem;System;Tacrolimus;Technology;technology intervention;telehealth;televisit;Testing;theories;Therapeutic;Time;Transplant Recipients;Transplantation;treatment arm;United States Agency for Healthcare Research and Quality;Veterans

PROJECT_TITLE: Multifaceted Intervention to Improve Graft Outcome Disparities in African American Kidney Transplants (MITIGAAT)

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Diabetes;Digestive Diseases;Genetics;Human Genome;Liver Disease;Nutrition

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative:  In human and rodent models of Insulin resistance, the regulation of gluconeogenesis is altered such that hepatic glucose production is enhanced in the fasted state with reduced suppression in the fed state. In parallel, hepatic de novo lipogenesis is elevated in fasted state and further increased in the fed state. The inability of insulin to suppress hepatic glucose output but still to activated de novo lipogenesis has been referred to as selective insulin resistance. To understand the long-term epi- genetic changes responsible for the dysregulation in the liver, we are examining the basic transcriptional events that regulate gluconeogenic and lipogenic genes in normal and insulin resistant states through modulation of RNA Polymerase II. In this proposal we will use several high-end sequencing approaches that include ChRO-Seq, ChIP-Seq, ATAC-Seq, single cell RNA-Seq and single cell ATAC-Seq couple with single molecule FISH analyses.

PI_NAMEs: ELISCOVICH, CAROLINA INES;PESSIN, JEFFREY E. (contact);YANG, FAJUN JAMES

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acute;Address;Allosteric Regulation;Anatomy;ATAC-seq;Bile Acids;Binding;Cells;ChIP-seq;Chromatin;chromatin immunoprecipitation;Chronic;Complex;Cytochrome P450;Data;deep sequencing;Development;Diet;Distal;DNA;DNA Binding;Elongation Factor;Epigenetic Process;Event;FASN gene;Fasting;feeding;Fluorescent in Situ Hybridization;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;genomic platform;Gluconeogenesis;Gluconeogenesis Inhibition;glucose metabolism;glucose output;glucose production;Glutamine;Hepatic;Hepatocyte;human model;Hyperglycemia;Hypertriglyceridemia;Immunofluorescence Immunologic;Individual;Insulin;Insulin Resistance;lipid biosynthesis;lipid metabolism;Liver;liver function;Lobular;Measurement;Measures;Mediator;Messenger RNA;Metabolic;Metabolism;Molecular;Molecular Analysis;Mus;negative elongation factor;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;Organizational Change;oxidation;Pathogenesis;Pattern;Peptide Initiation Factors;Phosphorylation;Physiological;Play;Process;Protein Dephosphorylation;Regulation;response;RNA Polymerase II;Rodent Model;Role;Running;single cell ATAC-seq;single molecule;single-cell RNA sequencing;Site;Testing;Time;Tissues;Transcription Elongation;transcription factor;Transcription Initiation;Transcriptional Activation;Transcriptional Regulation

PROJECT_TITLE: Discordant transcriptional regulation of gluconeogenic and lipogenic gene expression


NIH_SPENDING_CATS: Biotechnology;Drug Abuse (NIDA only);Genetics;Infertility;Neurosciences;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE  It is increasingly recognized that non-human primates (NHP) such as marmosets provide an essential model to study higher brain function and dysfunction which are difficult to study in widely-used rodent models. This study will develop highly efficient genetic engineering tools and methods for genome engineering in marmosets allowing functional interrogation of the marmoset brain in healthy and disease models. The development of highly efficient methods will also significantly reduce the number of animals used for each study.

PI_NAMEs: FENG, GUOPING  (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Acceleration;Alleles;Animals;Area;assisted reproduction;Assisted Reproductive Technology;autism spectrum disorder;base editing;base editor;Biology;Biopsy Specimen;Brain;Brain Diseases;Breeding;Callithrix;Callithrix jacchus jacchus;Cell model;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;cost;Cryopreservation;data hub;Deposition;Development;Diagnostic;disease model;Embryo;embryo culture;Embryo Transfer;Engineering;Enhancers;Essential Genes;Evaluation;Female;Frequencies;Functional disorder;Gene Frequency;Generations;Genetic;Genetic Engineering;genetic manipulation;Genetic Models;genetic testing;Genome;genome editing;Genome engineering;Genotype;Goals;Heterozygote;Human;improved;in vivo;infancy;Injections;Knock-in;Macaca;Methods;Methyl-CpG-Binding Protein 2;model organism;Modeling;Modernization;Molecular;Mosaicism;Mus;mutant;Neurosciences;Neurosciences Research;nonhuman primate;novel;oocyte maturation;Oocytes;Persons;Preimplantation Diagnosis;prenatal;Primates;prime editing;Process;programs;Protocols documentation;Reagent;repaired;Reproductive Techniques;Research;Resource Sharing;Rett Syndrome;Rodent;Rodent Model;Sexual Maturation;Single Nucleotide Polymorphism;Standardization;Structure;Study models;Synaptic plasticity;System;Technology;Testing;Time;tool;Training;trait;translational neuroscience;Transposase;United States National Institutes of Health;Work;zygote

PROJECT_TITLE: A Genetic Engineering Toolbox for Marmosets (GETMarm): Development and optimization of genome editing and assisted reproduction techniques for marmoset models


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Machine Learning and Artificial Intelligence;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative For decades, inadequate behavioral treatment descriptions (including voice therapy) have been widely acknowledged as a critical barrier to the progress of behaviorally based medical professions. Using a standard framework—Voice therapy according to the Rehabilitation Treatment Specification System or RTSS-Voice— we will produce a list of mutually exclusive ingredients/targets across 9 well-known voice therapies. This work will improve the efficiency and usefulness of voice therapy research, enabling the systematic comparison of active ingredients across therapy programs; instead of the current practice of studying/comparing entire programs.

PI_NAMEs: VAN STAN, JARRAD  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Adopted;Adoption;Anatomy;Behavior Therapy;Behavioral;Categories;Classification;Clinical;clinical care;Clinical Data;common treatment;Communication;Comparative Effectiveness Research;Data;data mining;Data Set;Diagnosis;Diagnostic;Discipline;Disease;Dysphonia;Effectiveness;evidence base;Expert Opinion;Expert Systems;explainable machine learning;Focus Groups;Goals;improved;improved outcome;Individual;individualized medicine;Influentials;innovation;Label;Language;large datasets;Link;Machine Learning;Medical;Methods;Modification;Muscle Tension;novel;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Periodicals;Physiology;Process;programs;Publishing;Rehabilitation therapy;Research;Research Personnel;response;Shapes;Site;Specific qualifier value;System;Taxonomy;Terminology;Testing;theories;Therapeutic Studies;therapy outcome;Time;Translations;Variant;Voice;Voice Disorders;voice therapy;Work

PROJECT_TITLE: RTSS-Voice: Towards a unified system to classify treatments for muscle tension dysphonia

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Dissemination and Implementation Research;Genetics;Health Services;Human Genome;Pediatric;Prevention;Primary Health Care

ORG_DEPT: GENETICS

PHR: Project Narrative Genomic medicine seeks to improve clinical outcomes and public health, and identification of clinically actionable inherited genetic conditions before symptoms manifest can enable physicians to intervene earlier and achieve these goals. The newborn screening program exemplifies this paradigm but is limited to a narrow subset of conditions relevant at birth, thereby missing the opportunity to identify many other similarly actionable conditions. Given the many challenges associated with clinical whole genome sequencing in the newborn period, we propose to expand the scope of genomic screening by offering parents targeted sequencing of their children at distinct time-points during development, to discover actionable genetic conditions when that information would have the greatest relevance.

PI_NAMEs: BERG, JONATHAN S (contact);MILKO, LAURA VOGEL

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Address;Adult;Age;age group;Age of Onset;Applied Genetics;Awareness;Benefits and Risks;Biological Assay;Birth;Child;Child Care;Child health care;Childhood;Clinic;Clinical;clinical trial implementation;clinically actionable;clinically relevant;Collaborations;Communities;community based participatory research;community clinic;community engagement;Consensus;Data;Decision Making;design;Development;Disease;economic outcome;education resources;Eligibility Determination;Ethics;Expert Opinion;Feedback;Future;Genetic Diseases;genetic information;Genetic Medicine;genetic variant;genome sequencing;genome-wide;Genomic medicine;Genomics;Goals;Health;health economics;Healthcare;implementation facilitators;implementation framework;implementation outcomes;implementation strategy;implementation trial;improved;Individual;infancy;Infant;Inherited;innovation;Intervention;Interview;Laboratories;Leadership;life span;Longitudinal Studies;Maps;Measures;Methods;Modeling;Neonatal Screening;Newborn Infant;novel;organizational readiness;Outcome;Parents;Perception;Physicians;Pilot Projects;Population;pragmatic study;prevent;Primary Care;primary care setting;Process;programs;Protocols documentation;Provider;Public Health;Qualitative Methods;rare mendelian disorder;reduce symptoms;Research;research and development;Resources;Risk;screening;screening program;Screening Result;Site;social;Specific qualifier value;Symptoms;targeted sequencing;Technology;technology validation;Time;Training;Training and Education;Treatment Efficacy;Underrepresented Populations;Underserved Population;Variant;Well Child Visits;whole genome;Work

PROJECT_TITLE: Age-based genomic screening in newborns, infants, and children: a novel paradigm in public health genomics


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Chronic Pain;Clinical Research;Fibromyalgia;Infectious Diseases;Lupus;Pain Research;Precision Medicine;Psoriasis

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE The goals of this K24 application are to support Dr. Kahlenberg’s continued development as a mentor and to sustain and expand a successful research training program for Patient-Oriented Research (POR) through an interdisciplinary translational research program which focuses on disease mechanisms and outcomes in rheumatic diseases. The awarding of the K24 Mid-Career Investigator Award would ensure that the candidate has significant time for mentoring current and future mentees and securing funding to support her research program. Discoveries supported by and mentees supported through this research are directly relevant to the NIH’s mission to foster fundamental discoveries and their applications to protect and improve public health.

PI_NAMEs: KAHLENBERG, JOANNE MICHELLE (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Arthritis;autocrine;Autoimmune;Award;B-Lymphocytes;Biology;biomarker discovery;Biometry;career;Cells;Center for Translational Science Activities;chemokine;Chronic;chronic pain;chronic widespread pain;Clinical;clinical development;Clinical Trials;Clinical Trials Design;cohort;Collaborations;Complication;Data;Data Set;Development;Disease;disease phenotype;Ensure;Environment;Fatigue;Fibroblasts;Fibromyalgia;Fostering;Functional disorder;Funding;Future;Genotype;Goals;Immune;Immunophenotyping;improved;In Vitro;in vivo;indexing;Inflammation;Inflammatory;Inflammatory Response;Infrastructure;innovation;Institution;Interferons;Joints;keratinocyte;large scale data;Lesion;Link;Lupus;lupus cutaneous;Maps;Measures;meetings;Mentors;Mentorship;microbial colonization;microbial products;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;Mission;Monitor;monocyte;mouse model;Mupirocin;next generation;novel;Outcome;Pain;Pain Measurement;Pain Research;pain sensitivity;Pathogenesis;patient oriented research;patient subsets;Patients;personalized medicine;Pharmaceutical Preparations;Phenotype;Physicians;Population;Prediction of Response to Therapy;Production;programs;promoter;Psoriasis;Psoriatic Arthritis;Public Health;Regulation;Research;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Training;response;Rheumatism;Rheumatology;Science;Scientist;Secure;Sensory;Signal Transduction;skills;Skin;skin biopsy;skin disorder;Staphylococcus aureus;Systemic Lupus Erythematosus;T-Lymphocyte;Time;tool;Topical application;training opportunity;Training Programs;translational research program;treatment response;Ultraviolet B Radiation;United States National Institutes of Health;Work

PROJECT_TITLE: Linking Disease Mechanisms and Outcomes in Rheumatic Diseases

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The introduction of high-cost newer glucose-lowering drugs (GLDs) has led to significant quality and equity concerns in diabetes care: socially disadvantaged individuals tend to have limited access to newer GLDs due to barriers related to social attributes (e.g., income, education), resulting in gaps and disparities in achieving optimal health outcomes. Previous studies have found that programs that improve the quality of care by promoting treatment in targeted clinically high-benefit user groups lead to equity improvement because high- benefit users from socially disadvantaged subgroups often have larger gaps in care thus benefit more from these programs. In the proposed project, we will identify clinically high-benefit T2D patient subgroups for newer GLDs, and generate empirical economic evidence for designing policy-level interventions to improve the quality of care and health equity in T2D care.

PI_NAMEs: GUO, JINGCHUAN  (contact);SHAO, HUI

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: American;cardiovascular disorder risk;Cardiovascular system;care seeking;Caring;Clinical;clinical care;Clinical Research;comparative effectiveness;Comparative Effectiveness Research;comparative safety;computable phenotypes;cost;Cost Sharing;Data;design;diabetes management;Diabetes Mellitus;diabetes prevention program;Disparity;Disparity population;Drug Exposure;Drug usage;economic evaluation;economic outcome;Economics;Education;Effectiveness;Electronic Health Record;electronic health record system;Equity;Event;experimental study;forest;Glucose;Gold;Guidelines;Health;health disparity;health equity;health plan;Health system;Heterogeneity;high risk;improved;Income;Individual;innovation;Insurance;Intervention;Kidney Diseases;Knowledge;Lead;Legal patent;Link;Louisiana;Machine Learning;machine learning algorithm;machine learning method;Marketing;Measurement;Medicaid;Medical;Medicare;medication compliance;Methods;models and simulation;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;patient oriented;patient subsets;Patients;Penetration;Persons;Pharmaceutical Preparations;phenotyping algorithm;Policies;Privatization;programs;Proliferating;Public Health;Quality of Care;Recommendation;Records;Research;Safety;Screening for cancer;screening program;simulation;social;social disparities;social health determinants;Structure;study population;Subgroup;System;treatment effect;United States Food and Drug Administration;uptake;Work

PROJECT_TITLE: Building Equity Improvement into Quality Improvement in the use of New Glucose-lowering Drugs (GLDs) through Individualized Drug Value Assessment in People with Diabetes

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Narrative Many cells in our body, such as skin cells that provide a physical barrier to the environment, are polarized and loss of polarity is a hallmark of many diseases, including cancer. We are investigating how animal cells are polarized and how polarity is used in specialized processes such as differentiation. As the loss of polarity is associated with human disease, improving our understanding of the molecules that control this process will contribute to our knowledge of the mechanisms of disease states.

PI_NAMEs: PREHODA, KENNETH E (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Animal Organ;animal tissue;Animals;Area;Brain;Cell division;Cell Line;Cell membrane;Cell Physiology;cell type;Cells;Complex;Disease;Environment;Gastrointestinal tract structure;human disease;improved;Malignant Neoplasms;Membrane;Molecular;Neurons;Nutrient;polarized cell;Process;Proteins;Rest;Set protein;Side;Skin;Structure;Time;Tissues;Translating;Work

PROJECT_TITLE: Molecular mechanisms that control polarity and asymmetric cell division

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Kidney Disease;Regenerative Medicine

ORG_CITY: ALBANY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: Narrative Despite extensive research efforts, we still do not know if an adult kidney contains specific cells that can produce new cells to replace the dead ones under normal and disease conditions. Identification of such cells is important for understanding developmental defects and for regenerative medicine. This project is built on our recent work showing that cells expressing water channel Aqp2 and V-ATPase subunits B1 and B2 are the first candidate of such cells in mouse kidneys. These cells are called Aqp2+ progenitor cells or AP in short. We will use a set of cutting-edge techniques to identify AP's molecular signature, to evaluate AP's regenerative potential, and to determine if their regenerative potential is different between males and females and regulated by Jag1.

PI_NAMEs: ZHANG, WENZHENG  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Adult;analog;Antibodies;Behavior;biomarker identification;Cell Count;Cell Lineage;Cell Separation;cell type;Cells;Classification;Clone Cells;Data;Data Set;daughter cell;Defect;Development;Disease;Distal convoluted renal tubule structure;Duct (organ) structure;Embryo;Exhibits;extracellular;Female;Foundations;Future;Generations;Histologic;Human;Human Pathology;Immune;Immunofluorescence Immunologic;improved;In Situ Hybridization;In Vitro;in vivo;Inherited;Injury;injury and repair;innovation;insight;Intercalated Cell;Kidney;kidney cell;kidney fibrosis;Label;Ligands;Link;Maintenance;male;Mediating;Molecular Profiling;Mus;Natural regeneration;notch protein;novel;novel marker;Organoids;Osmolalities;Pathway interactions;Property;Publishing;regeneration potential;regenerative;Regenerative Medicine;Regulation;repaired;Reporting;Research;self-renewal;sex;Sex Bias;Signal Transduction;single-cell RNA sequencing;Solid;Stains;stem cell biology;stem cell biomarkers;stem cells;Tamoxifen;Techniques;Testing;Therapeutic;Thymidine;Tissues;transcriptome;transcriptome sequencing;Transitional Cell;Ureteral obstruction;Urinary tract infection;vacuolar H+-ATPase;water channel;Work

PROJECT_TITLE: The Regenerative Potential of Aqp2+ Progenitor Cells

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Hypertension;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE Control of hypertension, dyslipidemia, and smoking can reduce the high rates of cardiovascular disease (CVD) and related deaths by fifty percent with effective management of the treatment cascade involving screening, treatment initiation, and medication adherence. Despite the government of Argentina providing universal health care coverage, free health services, and free essential medications for the poorest segment of the population, very little improvement in overall CVD risk has resulted from these policies. Partnering with the Argentinian Ministry of Health, we will evaluate the effectiveness and cost-effectiveness of implementing a multi- component intervention that is global data management system linking digital mHealth screening tool for CHWs, electronic appointment scheduling, point of care testing (POCT) for lipids, clinical decision support for medication initiation, and a SMS reminder system for adherence to medications and life-style changes.

PI_NAMEs: GAZIANO, THOMAS A (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: Adherence;Adult;Appointments and Schedules;Area;Argentina;Argentine;arm;Awareness;Blood Pressure;blood pressure reduction;Calibration;Cardiovascular Diseases;cardiovascular disorder risk;Caring;Cessation of life;Cholesterol;Chronic;Chronic Disease;Clinic;clinical decision support;Clinical effectiveness;Collaborations;Communities;Community Health Aides;Complex;Continuity of Patient Care;cost;cost effective;cost effectiveness;cost-effectiveness evaluation;Country;Data Management Resources;Diagnostic;digital;Disparity;Dyslipidemias;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Electronics;Elements;Eligibility Determination;Evaluation;evidence base;experience;Federal Government;Feedback;formative assessment;Funding;Goals;Government;Grant;Guidelines;Health;Health Policy;Health Services;Health system;Healthcare;Hypertension;hypertension control;implementation evaluation;implementation framework;implementation intervention;implementation strategy;implementation/effectiveness;improved;Income;innovation;Intervention;Journals;Life Style;Link;Lipids;low and middle-income countries;medication compliance;Medicine;meetings;Methods;mHealth;mortality;multi-component intervention;Myocardial Ischemia;Paper;Patient Participation;Peer Review;Pharmaceutical Preparations;Phase;point of care testing;Policies;Population;predictive modeling;Premature Mortality;prevent;primary care clinic;primary health service;primary outcome;programs;Provider;Province;Public Health;Publications;randomized, clinical trials;Randomized, Controlled Trials;Reminder Systems;Research;Research Personnel;Risk Factors;Schedule;screening;screening guidelines;Screening procedure;Series;Smoking;Structure;System;tobacco control;tool;treatment arm;treatment guidelines;Underserved Population;Uninsured;United States National Institutes of Health;Universities;usual care arm;Work

PROJECT_TITLE: PRIMECare Trial: Preventing Ischemic Heart Disease with mHealth, electronic decision support, and Community Health Workers.

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Anxiety Disorders;Asthma;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Exposure to violence and violence-related distress may cause asthma to persist or worsen between childhood and early adulthood in inner-city and minority populations. Elucidating these violence-related effects and their pathways will have major implications for asthma prevention and management, particularly in the economically disadvantaged and members of ethnic groups heavily affected by asthma, such as Puerto Ricans.

PI_NAMEs: CELEDON, JUAN CARLOS (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Abbreviations;Adolescent;Adult;Affect;associated symptom;Asthma;asthma prevention;British;Bronchodilator Agents;Child;Child Abuse and Neglect;Childhood;Childhood Asthma;cohort;Cross-Sectional Studies;Data;Distress;economic disparity;emerging adult;Environment;epigenetic variation;Ethnic Population;Generalized Anxiety Disorder;Genetic;Goals;health disparity;inner city;Interdisciplinary Study;Knowledge;Life Style;Literature;Major Depressive Disorder;Mediating;Mediation;Mediator;member;Mental disorders;Methods;Minority;Minority Groups;Nonpharmacologic Therapy;novel;novel strategies;older adult;Outcome;Pathogenesis;Pathway interactions;pharmacologic;prevent;Prevention;Prevention approach;preventive intervention;Prospective Studies;psychosocial stressors;Publishing;Puerto Rican;Puerto Rico;pulmonary function;Quality of life;Regulatory Pathway;response;Risk;Role;Severities;stress reduction;Symptoms;Testing;Therapeutic Intervention;Time;underserved minority;Underserved Population;Violence;violence exposure;young adult;Youth

PROJECT_TITLE: Exposure to violence during childhood and Th2-high asthma in young Puerto Rican adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-G(02)M]