ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Neurosciences;Physical Activity;Prevention;Substance Misuse

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Healthy and consistent physical activity (PA) is crucial for our health and well-being; however, its use as a treatment option for alcohol use disorders (AUDs) remains undervalued and understudied. Therefore, the goals of this application are to 1) determine whether acute or chronic voluntary physical activity reduce binge-like ethanol drinking in a genetic risk model of drinking to intoxication, 2) characterize the neural circuits engaged during acute and chronic voluntary wheel-running, and 3) use a circuit-based approach to test the role of a known alcohol-related projection in driving acute and chronic wheel-running. These studies have the potential to provide a better comprehension of the neural mechanisms responsible for regulating alcohol use through continued engagement in physical activity.

PI_NAMEs: GRIGSBY, KOLTER  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Acute;acute stress;Address;Adult;Alcohol consumption;alcohol effect;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;American;Amygdaloid structure;Automobile Driving;Behavioral;binge drinking;Brain;Brain region;C57BL/6 Mouse;Cell Nucleus;Chronic;Complex;Comprehension;Consumption;cost effective;Darkness;designer receptors exclusively activated by designer drugs;Development;drinking;estrogenic;Ethanol;Evaluation;exercise intervention;Female;FOS gene;genetic manipulation;Genetic Risk;Goals;Guidelines;Health;Health Benefit;Heavy Drinking;Human;Immunohistochemistry;immunoreactivity;improved;Insula of Reil;Interoception;Intoxication;Literature;Maintenance;male;Measures;Medial;Modeling;motivated behavior;Mus;National Institute on Alcohol Abuse and Alcoholism;neural;neural circuit;neural network;neuromechanism;Nucleus Accumbens;Personal Satisfaction;Physical activity;Physiological;Play;Population Study;pre-clinical;preference;Preoptic Areas;prevent;Psychological reinforcement;Rattus;Recombinant adeno-associated virus (rAAV);Reporting;Rewards;Rodent;Role;Running;sex;Sex Differences;sexual dimorphism;Slice;social;Stress;System;Testing;Therapeutic;Tracer;Training;Translating;Ventral Tegmental Area;Work

PROJECT_TITLE: A circuit-driven evaluation of the use of physical activity interventions to improve binge-like ethanol drinking


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Tumor plasticity plays a key role in the development of tumor heterogeneity and a tumor’s resistance to chemotherapy. We discovered a high plasticity cell state that appears to drive tumor evolution and therapy resistance in lung adenocarcinoma. Clarifying what role this highly plastic cell state plays during tumor progression and determining the molecular drivers behind this critical state will improve our fundamental understanding of how advanced cancer states develop and resist antineoplastic therapies.

PI_NAMEs: CHAN, JASON EARL (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: 3-Dimensional;Ablation;Adenocarcinoma Cell;Advanced Malignant Neoplasm;Advisory Committees;allotransplant;American;Antineoplastic Agents;Area;Award;Bioinformatics;Biology;Cancer Biology;cancer cell;Cancer Etiology;cancer genetics;carcinogenesis;career;career development;Cells;Chemoresistance;chemotherapy;Clinical;clinical training;Complementary DNA;CRISPR/Cas technology;Data;Development;Development Plans;Educational workshop;Environment;Evolution;experience;experimental study;expression vector;Foundations;Funding;Genetic;Genetic Transcription;Genetically Engineered Mouse;Genomics;Goals;Histology;Human;human disease;improved;in vivo;in vivo Model;inhibitor;insight;Institution;instructor;Laboratories;Lung Adenocarcinoma;Lung Neoplasms;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medical Oncologist;Medical Oncology;Medicine;Memorial Sloan-Kettering Cancer Center;Mentors;Methods;Modeling;Molecular;Molecular Biology;Molecular Biology Techniques;mortality;mouse model;novel;novel strategies;novel therapeutics;overexpression;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phenotype;Physicians;Play;programs;Proteins;Reporter;Reproducibility;Research;Research Personnel;Research Project Summaries;Resistance;response;Role;Sarcoma;Scientist;single cell mRNA sequencing;small hairpin RNA;Source;spheroids;Stress;synergism;System;Systems Biology;tenure track;Testing;Therapeutic;therapy resistant;Time;Training;transcription factor;transcriptome;transdifferentiation;Translating;translational cancer research;tumor;Tumor Burden;tumor heterogeneity;tumor progression;Tumor stage;United States;Work;Xenograft Model

PROJECT_TITLE: Determining the role and function of a high plasticity cell state in lung adenocarcinoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NOTRE DAME

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE This project addresses the neglected issue of how interactions among distinct, co-circulating pathogens—through biological, behavioral, or clinical means—affect their joint dynamics. A new modeling framework will be developed that leverages surveillance data and other information about each pathogen and various hypothesized interactions among them. These developments will inform forecasts of disease outbreaks by a set of three mosquito-borne pathogens in Brazil, and projections of how COVID-19 will shape the future epidemiology of other respiratory pathogens in Indiana.

PI_NAMEs: PERKINS, ALEX  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TITLE: Model-based inference and forecasting of co-circulating pathogen dynamics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Photoreceptor cells in the retina are highly compartmentalized neurons, and disruption of compartment-specific protein localization underlies various forms of inherited retinal degenerations. The proposed study is to understand i) mechanisms by which the compartment-specific protein localization is achieved in photoreceptors and ii) why/how photoreceptor cells die when these mechanisms are impaired. This study will build a foundation to develop novel treatments to preserve vision in related diseases.

PI_NAMEs: SEO, SEONGJIN  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 220kDa rod outer segment rim protein;Address;Appearance;Binding Proteins;Cells;Chimeric Proteins;Cilia;ciliopathy;Cone;Disease;disease model;efficacy evaluation;Estrogen Receptors;Excision;FLP recombinase;Foundations;Functional disorder;Genetic Recombination;Goals;Homeostasis;homologous recombination;Impairment;Individual;inherited retinal degeneration;Injections;Internal Ribosome Entry Site;Knowledge;Label;Link;Mediating;Membrane Fusion;Membrane Proteins;Molecular;Monitor;mosaic;Neurons;novel;Outcome Study;Photoreceptors;preservation;programs;Protein Biosynthesis;protein transport;Proteins;Reaction;Reporter;Reporter Genes;Research;Retina;Retinal Degeneration;retinal rods;Rod;Role;Signal Transduction;syntaxin 3;Tamoxifen;target SNARE proteins;Testing;Therapeutic;therapy development;trafficking;Transgenic Mice;Variant;Vision

PROJECT_TITLE: Compartmentalized protein localization in photoreceptors

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: Nashville

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Hospital acquired bacterial and fungal infections are a major threat to critically ill patients. Innate immunocytes retain memory of prior pathogen exposure, which primes them to elicit a robust antimicrobial response upon re- exposure to additional pathogens. The goal of this project is to advance our understanding of innate immunological memory at the molecular level so that it can be harnessed to protect against hospital acquired bacterial and fungal infections.

PI_NAMEs: MCBRIDE, MARGARET ANN (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Aconitic Acid;Affect;Agonist;Antigens;antimicrobial;Antimicrobial Resistance;Attenuated;Bacteria;Bacterial Infections;Biogenesis;Body Temperature;Bone Marrow;Cells;Cessation of life;Citric Acid Cycle;Clinical;combat;Complex;Critical Illness;cytokine;Data;Disease;Electron Transport;Enzymes;experimental study;Exposure to;first responder;Generations;Genes;Glycolysis;Goals;Gram-Negative Bacterial Infections;Hospitals;Host resistance;Immunity;Immunologic Memory;improved;In Vitro;in vivo;Infection;infection management;Infection prevention;Injury to Kidney;innate immune mechanisms;Innate Immune System;insight;Investigation;knock-down;Knock-out;Knockout Mice;Knowledge;Laboratories;Ligands;Light;Lipid A;liver injury;Lysosomes;Macrophage;Measures;Mediating;Medical Technology;Memory;memory retention;Metabolic;Metabolism;Microbe;microbial;Mitochondria;Modeling;Molecular;Mycoses;Natural Immunity;Nosocomial Infections;Oxidative Phosphorylation;pathogen;pathogen exposure;Pathway interactions;patient population;Patients;Phagocytosis;Phenotype;Physicians;Play;Production;Property;Prophylactic treatment;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Publishing;Reactive Oxygen Species;Recording of previous events;recruit;Research;Resistance to infection;Respiratory Burst;response;Role;Scientist;Small Interfering RNA;Staphylococcus aureus;Staphylococcus aureus infection;Succinate Dehydrogenase;Testing;TLR4 gene;Training;Translations;United States;Vaccine Adjuvant;Vaccines;Vacuole;Vulnerable Populations

PROJECT_TITLE: The role of Immunoresponsive gene 1 in protection against infection


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Heart attack remains a leading cause of death due to late recognition of people at risk, but genomic information present from time of birth promises to improve risk prediction. The applicant will derive and a new risk model that integrates genomic information with known lifestyle and traditional risk factors to predict risk of heart attack in individuals of diverse ancestries. Successful completion will lay the foundation for genome-based identification and treatment of people at risk of heart attacks.

PI_NAMEs: FAHED, AKL C (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Active Learning;Address;Adherence;Adoption;Advisory Committees;African;Age;age related;All of Us Research Program;Asian ancestry;Attenuated;biobank;Birth;Blood Glucose;Blood Pressure;Board Certification;Cardiology;cardiovascular risk factor;Cardiovascular system;career;Caregivers;Cause of Death;Cholesterol;Circulation;Clinical;Clinical Data;clinical practice;clinical risk;cloud based;Complex;Computational Biology;Coronary Arteriosclerosis;Data;data access;Data Set;Derivation procedure;Diet;disorder risk;East Asian;Environment;Environmental Exposure;European ancestry;Exercise;experience;Familial Hypercholesterolemia;Foundations;Funding;Future;General Hospitals;Genes;Genetic;Genetic Diseases;Genetic Risk;Genome;Genomic medicine;genomic variation;Genomics;Genotype;Grant;Hand;healthy lifestyle;Hematopoiesis;Hematopoietic stem cells;Heritability;Hispanic ancestry;Human Genetics;improved;Individual;individual variation;Inherited;instructor;Internal Medicine;International;Intervention;K-Series Research Career Programs;Knowledge;Life;Life Style;lifestyle data;Massachusetts;medical schools;Medicine;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;multi-ethnic;multidisciplinary;Myocardial Infarction;non-genomic;Paper;Participant;Performance;pharmacologic;Phase;Physicians;Play;Population;Populations at Risk;portability;Positioning Attribute;Postdoctoral Fellow;Predictive Analytics;predictive modeling;Prevention;Probability;Process;Productivity;Prospective, cohort study;Publishing;Race;Research;Research Personnel;responsible research conduct;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;Role;Scientist;skill acquisition;skills;Smoking;Somatic Mutation;South Asian;staff intervention;Subgroup;System;Testing;Time;Training;Training Activity;treatment risk;United States National Institutes of Health;Validation;Variant;Weight;Work;Writing

PROJECT_TITLE: Integrating genomic and nongenomic risk for coronary artery disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Woodscross

ORG_NAME: PHOENIX PHARMALABS, INC.

ORG_STATE: UT

PHR: Narrative There are currently no approved medications for psychostimulant abuse. Phoenix PharmaLabs has put together a program to develop a novel, non-selective opioid compound (PPL-138) that blocks cocaine and methamphetamine self-administration in rats but is not self-administered in rats or non-human primates. This program will encompass chemical manufacturing, required safety toxicology and all pre-IND studies, filing an IND, and Phase I clinical trials to determine safety in humans. The ultimate goal is to develop PPL-138 as a medication to treat cocaine and methamphetamine use disorder.

PI_NAMEs: LEVIN, FRANCES RUDNICK;LEVY, DANIEL ;TOLL, LAWRENCE R (contact)

PROGRAM_OFFICER_NAME: SEAGER, MATTHEW ALAN

PROJECT_TERMS: addiction;ADME Study;Affinity;Agonist;alcohol abuse therapy;Alcohols;Analgesics;Animals;antagonist;Attenuated;Behavior;Biological;Biological Availability;Blood Pressure;Brain;Buprenorphine;Businesses;Cardiovascular Physiology;Chemicals;Chronic;Clinical;Cocaine;cocaine seeking;cocaine self-administration;Cocaine use disorder;Code;Constipation;craving;Cross-Over Studies;Data;design;Development;Disease;Dose;Drug abuse;drug discovery;Drug Interactions;Drug Kinetics;drug of abuse;drug reward;Drug usage;effective therapy;Effectiveness;efficacy study;experience;experimental study;Eye;Family;Female;Financial Support;first-in-human;Formulation;Freeze Drying;Funding;Future;Goals;Heart Rate;Human;Human Volunteers;Husband;In Vitro;in vivo;inhibitor;Laboratories;Licensing;Ligands;Macaca mulatta;male;manufacture;manufacturing process development;Methamphetamine;methamphetamine abuse;Methamphetamine use disorder;mu receptors;Naltrexone;Names;National Institute of Drug Abuse;Nicotine;nonhuman primate;novel;Opioid;Opioid Receptor;opioid use;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phase I Clinical Trials;Polymorph;Powder dose form;pre-clinical;pre-IND studies;pre-Investigational New Drug meeting;preclinical development;preclinical study;prevent;Privatization;Process;process optimization;product development;programs;psychostimulant;Public Health;public-private partnership;pulmonary function;Rattus;receptor;Regulatory Affairs;Relapse;Research Priority;Respiration;Rewards;Rodent;Running;Safety;safety study;screening;Self Administration;sex;side effect;Societies;Sodium Chloride;Specific qualifier value;stability testing;stimulant abuse;success;System;Testing;Therapeutic;therapeutic development;Toxic effect;Toxicogenetics;Toxicology;Treatment Efficacy;Universities;Work

PROJECT_TITLE: Development of PPL-138, a Novel Mixed NOP/Mu Partial Agonist for Treatment of CocaineUse Disorder

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-S-L]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Clinical Research;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE In motor neuron diseases, neuromuscular junctions are lost and motor neurons degenerate resulting in progressive paralysis and death. Dysfunctional microRNA (miRNA) processing has been implicated in their pathogenesis and I previously discovered that a single miRNA, miR-218, is uniquely enriched and abundantly expressed in mouse motor neurons and regulates neuromuscular function. I will utilize a novel human induced pluripotent stem cell-derived model of cortico-motor development to investigate the gene regulatory and biological functions of miR-218 in human motor neurons to gain insights into this essential miRNA’s role in human neurodevelopment and disease.

PI_NAMEs: AMIN, NEAL DILIP (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3' Untranslated Regions;3-Dimensional;Advisory Committees;ALS patients;Antibodies;Autocrine Communication;Autopsy;Award;Axon;Bioinformatics;bioinformatics pipeline;Biological;Biological Assay;Biological Process;Biology;Brain;career development;Cessation of life;comparative;CRISPR/Cas technology;Defect;derepression;design;Development;Disease;Disease Pathway;DNA Sequence Alteration;Dose;Environment;Evolution;Exhibits;experience;expression vector;Functional disorder;Future;Gene Expression;Gene Expression Regulation;gene function;gene network;Genes;Glutamates;Goals;Histology;Human;human induced pluripotent stem cells;human model;Image;Induced Neurons;Inherited;insight;Investigation;Knowledge;Ligands;Mediating;Mediator;Mentors;Messenger RNA;MicroRNAs;Modeling;Motor;motor control;motor neuron degeneration;motor neuron development;Motor Neuron Disease;motor neuron function;Motor Neurons;mouse genetics;Mus;Muscle;Muscle Contraction;Mutation;Nervous System;neurodevelopment;Neurologist;neuromuscular;neuromuscular function;Neuromuscular Junction;Neuronal Dysfunction;Neurons;novel;optogenetics;Organoids;overexpression;Paralysed;Pathogenesis;Pathway interactions;Phenotype;Post-Transcriptional Regulation;predictive modeling;presynaptic;protein TDP-43;Proteins;receptor;Regulation;Regulatory Pathway;Reporter;Repression;Research;Resources;response;Role;Scientist;Skeletal Muscle;skills;spheroids;Spinal;stem cell biology;stem cell model;stem cell organoids;Synapses;synaptogenesis;System;Therapeutic;Tissues;Training;transcriptome sequencing;transcriptomics;Universities;Untranslated RNA

PROJECT_TITLE: Modulating miR-218 in human motor neurons using assembloids

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PUBLIC HEALTH RELEVANCE Although social isolation, loneliness, and social environment are increasingly recognized as important factors in Alzheimer’s disease and related dementias (ADRD), less is known about the biological processes by which these factors impact brain health and ADRD. We plan to study these relatively novel associations in detail by adding social isolation, loneliness, and social environment information to ongoing ADRD surveillance in the biologically well-characterized Framingham Study cohorts, relating these measures to extensive preclinical ADRD data from dementia-free Framingham participants of diverse racial/ethnic and socioeconomic backgrounds (neuropsychological and state-of-the-art omics and brain imaging—amyloid/tau-PET and volumetric/connectivity/perfusion-MRI), and using advanced computational analysis to characterize the cumulative biological role of these factors in ADRD. This would complement studies of the COVID-19 pandemic’s long-term population health impacts, help us better understand observed trends between psychosocial determinants of health and ADRD risk, clarify the magnitude of change needed in these factors for a meaningful improvement in health, advance health equity by supporting quantitative methods development to address root causes of disparities in ADRD, and, if validated, identify new treatment targets that may also strengthen individual and group psychosocial functioning.

PI_NAMEs: APARICIO, HUGO JAVIER;BALCER, LAURA ;SALINAS, JOEL ARMANDO (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Acceleration;Address;Adult;Age;Aging;aging brain;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;amyloid imaging;Anatomy;Automated Indexing;Biological;Biological Markers;Biological Process;Biology;Blinded;Blood;Brain;brain health;Brain imaging;Censuses;Clinical;Clinical Trials;Cognitive;cognitive function;cohort;Cohort Studies;Communities;Complement;Computer Analysis;Computer Vision Systems;Computing Methodologies;COVID-19 pandemic;cytotoxic;Data;data integration;Data Set;data sharing;database of Genotypes and Phenotypes;Dementia;dementia risk;Dimensions;Disparity;Economic Conditions;Enrollment;ethnic diversity;Ethnic Origin;examination questions;follow-up;Funding;Future;Generations;Genetic;Genetic Risk;Health;Health behavior;health determinants;health equity;Health Resources;Human;Image;imaging biomarker;Impaired cognition;improved;Incidence;indexing;Individual;Inflammation;Inflammatory;Information Networks;innovation;interest;Intervention;Intervention Studies;Intervention Trial;life span;Link;Loneliness;Long-Term Effects;Machine Learning;machine learning method;Magnetic Resonance Imaging;Measures;method development;Methods;Molecular;molecular marker;Molecular Profiling;multi-ethnic;Multiomic Data;multiple omics;Nerve Degeneration;neurobiological mechanism;Neurocognitive;Neuronal Plasticity;neuropathology;Neuropsychology;novel;open data;Participant;Pathway interactions;Pattern;Perfusion;population health;Population Study;Positron-Emission Tomography;pre-clinical;Prevalence;Prevention;Process;programs;Proteomics;psychosocial;Psychosocial Assessment and Care;Psychosocial Factor;Public Health;public health relevance;Publishing;racial diversity;repaired;Research;Research Priority;resilience;Resources;response;Risk;Role;social;Social Environment;Social isolation;Social Network;social relationships;socioeconomic disparity;Socioeconomic Factors;socioeconomics;Stress;Structure;tau Proteins;Translating;Treatment/Psychosocial Effects;trend;United States National Institutes of Health;Validation;Vascular Diseases;Vision;Work

PROJECT_TITLE: Identifying ADRD intervention targets by characterizing neurobiological mechanisms of social isolation, loneliness, and social environment using novel imaging, molecular markers, and machine learning

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Clinical Research;Lung;Prevention;Rare Diseases;Scleroderma

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Interstitial lung disease affects approximately 40-60% of adults with systemic sclerosis and is the leading cause of death in this population. Our goal is to understand how vasculopathy contributes to the development of interstitial lung disease in adults with systemic sclerosis. Ultimately, the results of our study will be used to identify new treatments to prevent the development and progression of interstitial lung disease in patients with systemic sclerosis.

PI_NAMEs: BERNSTEIN, ELANA  (contact)

PROGRAM_OFFICER_NAME: CHARYA, ANANTH VELUGALETI

PROJECT_TERMS: Adult;Affect;Alveolar;angiogenesis;Arteries;autoimmune rheumatologic disease;Autopsy;Biopsy;Blood capillaries;blood perfusion;Blood Vessels;Blood Volume;Carbon Monoxide;Cause of Death;cell injury;Cells;Clinical;Clinical Trials;contrast enhanced;Data;Death Rate;density;Development;Diffusion;digital;early onset;Endothelial Cells;Endothelium;Event;Fibrosis;fibrotic lung disease;Functional disorder;Goals;Hospitalization;illness length;indexing;Infection;Inflammation;Injury;Interstitial Lung Diseases;Intervention;Lung;Lung Diseases;Measures;Microscopic Angioscopy;Microvascular Dysfunction;Molecular;Neoplasms;new technology;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome Measure;Pathogenesis;Pathway interactions;Patients;Perfusion;Peripheral;peripheral blood;Population;prevent;Prevention;Primary Prevention;Prospective, cohort study;pulmonary function;pulmonary function decline;reactive hyperemia;Regulation;Research;response;Secondary Prevention;severe injury;single-cell RNA sequencing;Structure;Structure of parenchyma of lung;Systemic Scleroderma;Techniques;Testing;Time;tonometry;transcriptome;transcriptomics;Vascular Diseases;vascular endothelial dysfunction;Vascular Endothelium;vascular injury;vasculogenesis;Vasodilator Agents;Visualization;Vital capacity;X-Ray Computed Tomography

PROJECT_TITLE: Vasculopathy and Systemic Sclerosis-Associated Interstitial Lung Disease

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE Iatrogenic withdrawal affects up to 57% of children who receive sedative and analgesic medications in the pediatric intensive care unit (ICU), contributing to delayed recovery, patient and parental distress and prolonged hospitalization. Due to limitations in sample size and variable sets, studies on iatrogenic withdrawal in pediatric ICUs have primarily focused on the association of single risk factors, screening tools, and treatment regimens, without attention to early identification of at-risk children. This proposal will leverage a national, electronic health record derived database of over 200,000 pediatric ICU patients to investigate the full spectrum of risk factors associated with iatrogenic withdrawal and using both traditional biostatistics and machine learning will develop and test a predictive model enabling early identification of pediatric ICU patients before iatrogenic withdrawal develops.

PI_NAMEs: PATEL, ANITA K. (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Absence of pain sensation;Address;Admission activity;Adverse event;Affect;Age;Analgesics;analytical tool;Anxiety;Applications Grants;Artificial Intelligence;Attention;Award;Big Data;Biometry;career;career development;Caring;Child;Child Care;Childhood;Circadian Dysregulation;Circadian Rhythms;Clinical;Clinical Investigator;clinical practice;cohort;Critical Care;Critically ill children;Data;Data Element;data management;Data Science;Data Set;Databases;deep neural network;design;Development;Diagnostic;Distress;Dose;Early identification;Electronic Health Record;Electronics;Feasibility Studies;Fentanyl;Functional disorder;Funding;Future;gastrointestinal;Goals;Grant;Hallucinations;Health;Healthcare;Hospitalization;Hospitals;Iatrogenesis;Institution;Intensive Care Units;Intervention;Investigation;Knowledge;Laboratories;large datasets;Machine Learning;machine learning method;machine learning prediction;medication administration;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Midazolam;Mission;Modeling;Morbidity - disease rate;multidisciplinary;National Institute of Child Health and Human Development;Neurologic;next generation;novel;Patient risk;Patients;Pattern;Pediatric Hospitals;Pediatric Intensive Care Units;pediatric patients;Performance;Pharmaceutical Preparations;Phenotype;Physiological;Predictive Analytics;predictive modeling;Predisposition;Prevention;Procedures;Productivity;profiles in patients;Programming Languages;Recovery;Regression Analysis;Research;Research Personnel;Research Proposals;Resources;Risk;Risk Factors;risk prediction;Sample Size;Scientist;Screening procedure;Sedation procedure;sedative;Seizures;side effect;skills;success;supervised learning;Symptoms;Techniques;Testing;Time;time interval;Training;Training Programs;Treatment Protocols;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: A Machine Learning Approach to Predicting Iatrogenic Withdrawal in Critically-ill Children

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD(M)-1-M]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Pediatric;Rural Health

ORG_CITY: MILWAUKEE

ORG_NAME: 3D MOLECULAR DESIGNS

ORG_STATE: WI

PHR: Project Narrative The long-term goal of this project is to educate today’s high school students regarding the science of infectious diseases and the role that vaccines can play in protecting ourselves from future viral pandemics. Because today’s students are tomorrow’s citizens we hope to create an informed citizenry that appreciates science and the need to invest in basic science research efforts that create the science infrastructure that will lead to better health outcomes in the future.

PI_NAMEs: HERMAN, TIM M. (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: 3D Print;Active Learning;Amaze;Basic Science;Biology;Chemistry;Chicago;Communicable Diseases;Coronavirus;COVID-19 pandemic;Development;Disease Outbreaks;empowerment;Exhibits;experience;Future;future pandemic;Goals;hands on instruction;Health;high school;High School Student;Infrastructure;Investments;Knowledge;Learning;learning materials;Life;meetings;minority student;Modeling;Molecular;Molecular Biology;Nebraska;Outcome;outreach;pedagogy;Phase;Play;Process;program dissemination;programs;Proteins;recruit;Research;Role;Rural;School Teachers;Science;science teacher;Series;South Dakota;Students;teacher;teacher mentor;Teacher Professional Development;Technology;underrepresented minority student;Underserved Population;Vaccines;Veterans;viral pandemic;Virus

PROJECT_TITLE: Tomorrow's Science Today: Preparing for the Next Pandemic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: DC

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Disability Research;Hearing Loss;Pediatric;Rehabilitation;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE In this training project, college students with hearing loss who use listening and spoken language will acquire research experiences in several hearing sciences laboratories of mentors with hearing loss. While working and communicating with mentors as well as hearing peers, they will develop the capacity to become leaders in science, technology, engineering, mathematics and medicine.

PI_NAMEs: RATNANATHER, JOHN TILAK (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Acceleration;Advertisements;Affect;Area;Aromatase;Auditory;Biography;California;career;Child;Cochlear Implants;college;Communication;Communities;coping;Data;Data Analyses;deaf;disability;Educational Status;Emotional;Engineering;Ethnic Origin;Etiology;Evaluation;experience;Experimental Designs;Facebook;Funding;Gender;Goals;hard of hearing;Health;Hearing;Hearing Aids;hearing impairment;Human Resources;improved;Individual;Inosine Diphosphate;Instagram;Institution;Internships;intersectionality;Invisible disability;Laboratories;Language;Learning;Life;LinkedIn;Literature;Mainstreaming;meetings;member;Mentors;Minnesota;model development;Modeling;National Institute on Deafness and Other Communication Disorders;Noise;nonbinary;Occupations;Oral;Oregon;Paper;Pattern;peer;peer networks;Persons;Problem Solving;programs;Published Comment;Publishing;PubMed;Race;recruit;Research;Research Project Grants;Rice;Running;Schools;Science;science, technology, engineering, mathematics, and medicine;Scientist;Self Assessment;Seminal;Signal Transduction;skills;social;Socialization;Societies;socioeconomics;Student recruitment;Students;success;summer internship;summer program;summer research;Surveys;symposium;Technology;Text;TikTok;tool;Training;training project;Twitter;undergraduate research;Underrepresented Minority;Universities;university student;Update;web site;Work;Writing

PROJECT_TITLE: STEMM opportunities for college students with Hearing loss to Engage in Auditory Research (STEMM-HEAR


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: WEST LAFAYETTE

ORG_NAME: EXPLORE INTERACTIVE, INC.

PHR: Project Narrative This project helps to build the capacity of the future health science workforce of the United States by providing meaningful, project-based learning that targets science and engineering in elementary classrooms through augmented reality, an interactive digital media approach. Students solve problems and design solutions through a novel hybrid digital and hands-on platform with synchronous supports for students and powerful dashboards for educators built through this research and development. Cultivating intuition and collaboration skills into health science topics such as bioengineering through interactive, collaborative game-based activities that are feasible for delivery in diverse educational settings nurtures a healthy, robust and critical-thinking future society.

PI_NAMEs: THOMPSON, AMANDA MARIE (contact)

PROJECT_TERMS: Address;Adoption;Age;Algorithm Design;algorithm training;Algorithms;Area;Artificial Intelligence;artificial intelligence algorithm;Auditory;Augmented Reality;automated analysis;Behavior;Big Data;Biomedical Engineering;Child;classroom research;Collaborations;Complex;Creativeness;Critical Thinking;dashboard;Data Analyses;data dashboard;design;Development;Devices;digital;digital media;Discipline;diversity and inclusion;Education;Educational Curriculum;Educational process of instructing;Effectiveness;Elements;empowerment;Engineering;engineering design;Equipment;Evolution;expectation;experience;Feedback;frontier;Funding;Future;Goals;Grant;grasp;handheld mobile device;Health;Health Sciences;Home;Human;Human Resources;Hybrids;Immersion;improved;Industry;Infrastructure;insight;interactive visualization;interest;Intuition;Knowledge;Learning;learning strategy;Life;Light;Machine Learning;Magnetism;Marketing;Measures;Mentors;Mission;mobile application;Monitor;Nature;new technology;next generation;novel;Online Systems;Optics;Outcome;Perception;Personal Satisfaction;Phase;Problem Solving;Process;project-based learning;prototype;Publishing;Reporting;Research;research and development;research study;Resource-limited setting;Schools;Science;Science, Technology, Engineering and Mathematics;Scientist;Self Efficacy;simulation game;skills;Small Business Innovation Research Grant;Societies;software development;sound;STEM career;Students;success;Surveys;System;Target Populations;teacher;Technology;Testing;Thinking;Time;Training;United States;United States National Institutes of Health;usability;user-friendly;virtual;web platform;Work

PROJECT_TITLE: Augmented Reality Platform for Feedback and Assessment in STEM Elementary Education


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE Opioid addiction (OA) is a deadly public health burden in the United States and across the globe, and it continues to worsen, with more than 70,000 U.S. deaths in 2020—the highest on record. In spite of 30 years of research, we still do not have a clear understanding of why some people are more likely to become addicted than others, although we do know that a person’s genes are strongly related. Our proposed Integrative Omics Center for Accelerating Neurobiological Understanding of Opioid Addiction (ICAN) will coordinate a team of top genomics researchers from multiple institutions to conduct four interlocking studies that will put tools in the hands of researchers countrywide to make field-changing breakthroughs, which ultimately, will improve options for treating opioid addiction.

PI_NAMEs: JOHNSON, ERIC OTTO (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Acceleration;addiction;Alcohol Phenotype;Amygdaloid structure;analysis pipeline;Animal Model;Autopsy;Biological;Brain;Brain imaging;Brain region;brain tissue;Cells;Cessation of life;Choking;Clinical;cohort;Collection;Complex;Country;Data;data exchange;data modeling;Democracy;design;Development;Disease;Electronic Health Record;Ensure;Equation;experimental study;explainable artificial intelligence;Fertilization;Gene Expression Regulation;gene network;Genes;Genetic Transcription;genome wide association study;genomic locus;Genomics;Goals;Heterogeneity;High Performance Computing;Human;human model;improved;Individual;individual variation;Infrastructure;Ingestion;innovation;Institution;Laboratories;Link;Maps;Mentors;Meta-Analysis;Methods;Modeling;multiple omics;Neurobiology;Nicotine;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid user;outreach;Pathway interactions;Persons;Phenotype;Prefrontal Cortex;Public Health;Quantitative Trait Loci;Reproducibility;Research;Research Personnel;Resources;Risk;RNA;Rodent;Rodent Model;Sample Size;Science;Signal Transduction;Standardization;statistics;Study models;synergism;tool;transcriptome;Translating;translational model;Translations;United States;Universities;Validation;Variant;Visualization


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

PROJECT_TERMS: Acceleration;addiction;Annual Reports;Biological;Charge;Code;cohort;Collaborations;Communication;Communities;Consensus;Data;Decision Making;Documentation;Education and Outreach;Educational workshop;Ensure;Environment;Evaluation;Feedback;follow-up;Genes;Genetic;Goals;indexing;Infrastructure;Institution;Instruction;Internships;Journals;LinkedIn;Location;Manuscripts;Maps;meetings;National Institute of Drug Abuse;Neurobiology;Opiate Addiction;Peer Review;Performance;Persons;Preparation;Privatization;Problem Solving;Process;programs;protocol development;Protocols documentation;psychogenetics;Publications;Publishing;Recording of previous events;Reporting;Research;Research Personnel;Resolution;Resources;Rest;Role;Science;Scientist;Site;social media;statistics;Structure;Students;Substance Use Disorder;synergism;Technology;Training and Education;Training Programs;Twitter;Veterans;videoconference;Visual;web site;Work

PROJECT_TITLE: Administrative Core (AC)


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Data Science;Drug Abuse (NIDA only);Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Substance Misuse

PROJECT_TERMS: Acceleration;addiction;Address;analysis pipeline;Animal Model;Biological;Cloud Computing;Collaborations;Communities;Community Integration;Community Services;computerized data processing;cost effective;Data;Data Analyses;data ingestion;data pipeline;data portal;Data Set;data sharing;data sharing networks;Data Storage and Retrieval;data visualization;Development;Doctor of Philosophy;Documentation;Ensure;Environment;Epidemiology;Equation;experimental study;follow-up;gene network;Gene Targeting;Genetic;genome wide association study;Genomics;High Performance Computing;Human;human data;human model;Image;improved;Individual;Infrastructure;Ingestion;International;Intuition;Laboratories;Linkage Disequilibrium;Maps;member;Meta-Analysis;Metadata;Methods;Mission;Modeling;Multiomic Data;Neurobiology;online resource;Online Systems;Opiate Addiction;Performance;Phenotype;Population;Population Heterogeneity;power analysis;Principal Investigator;Procedures;Quality Control;repository;Research;Research Personnel;Resolution;Resource Informatics;Resources;Sampling;Secure;Site;Source;Standardization;statistics;Structure;Study models;Sum;Supercomputing;synergism;Techniques;Technology;Testing;tool;user-friendly;Variant;web portal;working group

PROJECT_TITLE: Synergy Core (SynC)


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Genetics;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Opioid Misuse and Addiction;Opioids;Patient Safety;Substance Misuse

PI_NAMEs: TROIANI, VANESSA  (contact)

PROJECT_TERMS: Acceleration;Acute Pain;alcohol misuse;Algorithms;Anatomy;Autopsy;biobank;Bioinformatics;Brain;brain behavior;Brain imaging;brain magnetic resonance imaging;Brain region;brain volume;chronic pain;cigarette smoking;Classification;Clinical;clinical care;Clinical Data;clinical diagnosis;Code;cohort;Data;Data Collection;Data Sources;Diagnostic;Disease;Documentation;Dose;Drug usage;Electronic Health Record;Electronic Medical Records and Genomics Network;Emergency department visit;Equation;Ethnic Origin;experimental study;Face;follow-up;Future;Gene Expression;Gene Expression Regulation;gene network;Genes;Genetic;genetic architecture;genetic risk factor;Genetic study;genome wide association study;Genomic medicine;Genomics;Genotype;Goals;Health system;Healthcare Systems;Heritability;Heterogeneity;high dimensionality;Hospitalization;Human;Image;improved;in silico;injury-related death;insight;learning algorithm;Link;Magnetic Resonance Imaging;Measurement;Measures;Mediator;Medical;Mental disorders;Methods;Modeling;morphometry;mu opioid receptors;multiple data types;multiple omics;National Human Genome Research Institute;Neurobiology;novel;novel strategies;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid use;Overdose;Pathway Analysis;Patient imaging;Patients;Pattern;Persons;Pharmaceutical Preparations;Phenotype;psychiatric comorbidity;psychogenetics;Publishing;radiological imaging;rare variant;Receptor Gene;Recording of previous events;Records;Research;Resources;Risk;Risk Factors;risk prediction;risk variant;Rodent Model;Sampling;Series;sex;Site;statistics;Structure;Substance abuse problem;Substance Use Disorder;synergism;tool;United States;unsupervised learning;Validation;Variant

PROJECT_TITLE: EHR Phenotyping and Genomics of Opioid Addiction (Project 1)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE A persistent challenge to the design of effective influenza vaccines and forecasting of viral evolution and epidemiology is uncertainty about the immune responses underlying protection from infection. Here we propose to apply advanced statistical and computational methods and multimodal single cell analyses to identify the correlates and drivers underlying protection from infection and individual heterogeneity in vaccine responses. The work leverages a dozen longitudinal immuno-epidemiological studies of influenza virus infection and vaccination in humans.

PI_NAMEs: COBEY, SARAH  (contact);COWLING, BENJAMIN JOHN;TSANG, JOHN S

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Address;Affect;Age;Animal Model;Antibodies;Antibody titer measurement;Antigenic Variation;Antigens;Cells;Characteristics;cohort;Computing Methodologies;Data;design;Development Plans;Dimensions;Disease;Ensure;Epidemiology;epidemiology study;Evolution;Future;Generations;Hemagglutinin;Heterogeneity;Human;human model;Immune;Immune response;Immunity;immunological status;immunoregulation;improved;Individual;individual variation;Infection;infection risk;Influenza;influenza infection;Influenza vaccination;influenza virus vaccine;insight;Knowledge;Longitudinal Studies;Machine Learning;Maintenance;Mediation;Membrane Proteins;Memory;Methods;Modeling;multimodality;National Institute of Allergy and Infectious Disease;Neuraminidase;neutralizing antibody;novel;novel strategies;pathogen;Persons;Population;Population Heterogeneity;predicting response;pressure;Public Health;Recording of previous events;Research;Resources;response;Sampling;Scientist;seasonal influenza;Severities;sex;Signal Transduction;single cell analysis;Statistical Methods;Strategic Planning;T-Lymphocyte;Time;tool;Training;Uncertainty;universal influenza vaccine;Vaccination;vaccination strategy;vaccine development;vaccine effectiveness;vaccine failure;vaccine response;Vaccines;Variant;Viral;viral fitness;Work

PROJECT_TITLE: Drivers of individual variation in influenza vaccine response and protection from infection


NIH_SPENDING_CATS: Cooley's Anemia;Genetics;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: NARRATIVE Most cells contain protective quality control mechanisms that recognize and eliminate unstable toxic proteins. We discovered a red blood cell protein quality control pathway that can be manipulated to alleviate ß- thalassemia, a chronic life-threatening disorder of the blood oxygen carrier hemoglobin affecting approximately 60,000 newborns each year. Our proposed studies will provide scientific insights into how normal red blood cell precursors produce massive amounts of hemoglobin safely and efficiently and identify innovative new treatment strategies for patients with ß-thalassemia.

PI_NAMEs: WEISS, MITCHELL J (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: 5'-AMP-activated protein kinase;Ablation;Adult;Affect;Alleles;alpha Globin;Anemia;Apoptosis;Attenuated;Autophagocytosis;beta Globin;beta Thalassemia;Biological Markers;Biology;bone;CD34 gene;Cell Line;Cells;Chronic;cofactor;Complex;cytotoxic;Data;Deformity;derepression;Disease;Dose;Drug Metabolic Detoxication;Elements;Erythroblasts;Erythrocyte Transfusion;Erythrocytes;Erythroid;Erythroid Cells;Erythropoiesis;FRAP1 gene;Functional disorder;Gene Mutation;Genetic;Goals;Hematological Disease;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobin;Hemoglobinopathies;Hemolysis;hepcidin;Human;immunodeficiency;Impairment;improved;In Vitro;in vivo;inhibitor;innovation;insight;Iron;Iron Chelating Agents;Iron Chelation;Iron Overload;Life;low and middle-income countries;Mediating;Messenger RNA;MicroRNAs;mimetics;Mus;new therapeutic target;Newborn Infant;novel therapeutic intervention;novel therapeutics;Oxygen;Pathology;Pathway interactions;Patient Selection;Patients;pharmacologic;Phosphotransferases;Pre-Clinical Model;prevent;Process;Production;protein aggregation;protein degradation;Proteins;proteostasis;Quality Control;Regulation;Reporting;Repression;response;Severities;Sickle Cell Trait;Sirolimus;STK11 gene;Testing;Therapeutic;Therapeutic Effect;Translating;Transplantation

PROJECT_TITLE: ULK-mediated autophagy of α-globin in ß-thalassemia

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

PI_NAMEs: SCACHERI, PETER CHRISTOPHER (contact)

PROJECT_TERMS: Acceleration;Acute;addiction;Addictive Behavior;Amygdaloid structure;Architecture;Autopsy;Basal Ganglia;Behavior;Behavioral;Biological;Brain;Brain region;brain tissue;cell type;Cells;ChIP-seq;Chronic;cohort;Collection;Complex;compulsion;Data;Data Analyses;Data Set;Dependence;Development;Dimensions;DNA Methylation;Dorsal;drug discovery;Environmental Risk Factor;epigenome;executive function;Fluorescence-Activated Cell Sorting;follow-up;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic;genetic association;Genetic Engineering;genetic variant;Genome;genome wide association study;genome-wide;Genomics;Genotype;Goals;gun homicide;Histone Acetylation;histone modification;Human;human tissue;Impulsivity;in vivo;incentive salience;Individual;Injections;Intervention;Intoxication;Lateral;Link;Maps;Measurement;Meta-Analysis;Methylation;Motivation;multiple omics;Mus;negative affect;neural;Neurobiology;novel;novel therapeutics;Nucleus Accumbens;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid exposure;opioid mortality;opioid overdose;opioid use;overdose death;Pathway interactions;Pharmacology;Prefrontal Cortex;Public Health;Quantitative Trait Loci;Regulatory Element;Resources;Rewards;RNA;Sampling;single cell analysis;single cell ATAC-seq;Single Nucleotide Polymorphism;single-cell RNA sequencing;Site;Stress;Substance abuse problem;Substance Use Disorder;Surveys;synergism;targeted treatment;Testing;theories;Time;Tissues;Transcript;transcriptome;transcriptome sequencing;Validation;Variant;Viral Vector;Withdrawal;Work

PROJECT_TITLE: Gene Regulation in the Opioid Dependent Human Brain (Project 2)


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

PHR: Bringing together the tools of imaging, artificial intelligence (AI) based image analysis, computer sciences, cellular analyses, cancer biology, and immunology will be necessary to solve current problems in oncology and find innovative solutions that can expand the number of cancer patients who will benefit from conventional, targeted and immunotherapies. This innovative cancer training program will prepare the next generation of leaders in molecular imaging and cancer systems analysis science with a combination of mentored research, coursework in a collaborative environment that has a proven record of integrating multiple disciplines to translate science to clinical practice.

PI_NAMEs: WEISSLEDER, MD, PHD, RALPH  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: TRAINING GRANT IN MOLECUCLAR IMAGING RESEARCH AND CANCER SYSTEMS ANALYSIS

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

PI_NAMEs: JACOBSON, DANIEL A (contact)

PROJECT_TERMS: Acceleration;addiction;Address;Adult;Algorithms;Amygdaloid structure;Animal Model;Architecture;Autopsy;big-data science;Brain;brain control;brain tissue;cell type;ChIP-seq;Chromosome Mapping;Complex;Custom;Data;database of Genotypes and Phenotypes;Disease;DNA Methylation;Electronic Health Record;explainable artificial intelligence;Gene Expression Regulation;gene network;gene regulatory network;Genes;Genetic;Genetic Epistasis;genetic variant;Genome;genome wide association study;genome-wide;genomic locus;Genotype;Genotype-Tissue Expression Project;Goals;Heritability;High Performance Computing;Human;human data;Human Genome;human model;improved;Individual;International;Joints;Knowledge;Laboratories;Maps;Methods;Modeling;Morbidity - disease rate;mortality;Multiomic Data;multiple omics;Mus;Names;Neurobiology;Nucleus Accumbens;Opiate Addiction;Outcome;Output;Prefrontal Cortex;Process;Public Domains;random forest;Rattus;Rodent Model;Signal Transduction;Source;Study models;synergism;System;Systems Biology;Testing;Tissues;transcriptome sequencing;Trees;United States;Validation;Variant;Walking;Youth

PROJECT_TITLE: Multi-omics Gene Network Identification (Project 4)


ORG_CITY: OMAHA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative (Public Health Relevance) This project is addresses basic mechanisms that mediate lipid droplet catabolism and biogenesis, both of which are critical for fundamental cellular processes. Because LD catabolism is dysregulated in multiple diseases including fatty liver, obesity, diabetes, kidney disease and cancer, elucidating these mechanisms creates an opportunity to identify targets in LD catabolism that and improve human health.

PI_NAMEs: SCHOTT, MICAH  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Address;Adipose tissue;Biogenesis;Catabolism;Cell Physiology;Cholesterol Esters;Data;Diabetes Mellitus;Diglycerides;Disease;Encapsulated;Endosomes;Energy-Generating Resources;Enzymes;Fatty Liver;Health;Heterogeneity;Human;Hydrolysis;improved;Kidney Diseases;Knowledge;Lipase;lipid transport;Lipids;Mammalian Cell;Mediating;migration;monolayer;Nutrient availability;Obesity;Organelles;Peripheral;Phospholipids;Phosphorylation;Phosphotransferases;Process;protein activation;Protein Kinase C;Proteins;Proteome;public health relevance;recruit;Renal Carcinoma;Research;Role;Structural Protein;Surface;trafficking;Triglycerides

PROJECT_TITLE: Mechanisms of endosomal trafficking in lipid droplet catabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Data Science;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The proposed expansion and improvement of IPUMS-USA and support of the IPUMS database are directly relevant to the central mission of the National Institutes of Health. IPUMS data are advancing fundamental knowledge about health and population dynamics, and they directly support a vast body of research in one of the key priorities of the Population Dynamics Branch (PDB) of NICHD: Health and Disease across the Lifespan. IPUMS is a key source for research in each of the three PDB program areas: demography (including fertility, mortality, migration, population distribution, nuptiality, and family demography), reproductive health (including the long-run impact of fertility limitation), and population health (including basic measurement of morbidity and mortality among population subgroups).

PI_NAMEs: FLOOD, SARAH M;RUGGLES, STEVE  (contact);SOBEK, MATTHEW

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: American;application programming interface;Area;Behavioral Research;Censuses;Collaborations;Communities;Community Surveys;Computer software;cost;Data;data access;Data Analyses;data centers;Data Collection;data infrastructure;data ingestion;data management;data resource;data sharing;Data Sources;Databases;Demography;design;Development;Discipline;Disclosure;Disease;Documentation;Ensure;Evaluation;FAIR principles;Family;Family Demographies;Fertility;Geography;Goals;Grain;Growth;Health;health data;improved;Infrastructure;innovation;Knowledge;life span;Measurement;Medical Research;Metadata;metadata standards;migration;Mission;Modernization;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;Nuptiality;outreach;Population;Population Analysis;Population Distributions;Population Dynamics;population health;Population Research;preservation;programs;Publications;Reproductive Health;Research;Research Personnel;Resources;Running;Series;software development;Source;Subgroup;synergism;Systems Analysis;technology development;Time;tool;Training;United States National Institutes of Health;Update;usability;Work

PROJECT_TITLE: Microdata for Population Dynamics and Health Research

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE While it is now accepted that cell-to-cell variability affects viral infection outcome, we currently lack mechanistic understanding as to the host factors and transcriptional programs that control it. To gain such mechanistic insights requires the development of new approaches that are able to connect the cell’s initial state with infection outcome. This project will develop and apply state-of-the-art single cell approaches to decipher the molecular mechanisms that control viral infection outcomes at the single cell level.

PI_NAMEs: DRAYMAN, NIR  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Affect;Anti-viral Response;Anti-viral Therapy;Award;Biological Models;Biology;Cell Fraction;Cells;Cellular biology;cellular imaging;Collaborations;Custom;Data;design;Development;doctoral student;Gene Expression;Genetic Transcription;Germ Cells;Goals;Herpesvirus 1;high reward;high risk;improved;Infection;Infection Control;innovation;insight;Integration Host Factors;Investments;Life Cycle Stages;Literature;live cell imaging;Machine Learning;machine learning algorithm;Measurement;Methodology;Microfluidic Microchips;Microfluidics;Modality;Modeling;Molecular;Monitor;National Institute of Allergy and Infectious Disease;NF-kappa B;novel;novel strategies;Outcome;pathogen;pathogenic virus;Pathway interactions;Phenotype;Positioning Attribute;Probability;Process;Production;Productivity;programs;rational design;Research;Research Personnel;Resources;Science;secondary infection;Shapes;single-cell RNA sequencing;Supervision;System;Systems Biology;Technology;Testing;Therapeutic;Time;Titrations;TNF gene;tool;transcription factor;Validation;Viral;Viral Genes;virology;Virus;Virus Diseases;virus genetics;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Harnessing cell-to-cell variability to understand viral infection outcomes


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Lung;Pulmonary Hypertension;Rare Diseases;Scleroderma

PHR: Project Narrative We hypothesize that the enzyme xanthine oxidoreductase (XOR) and oxidative stress from XOR-derived reactive oxygen species influence development and progression of pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). This project examines XOR enzymatic activity and oxidative stress as potential contributors to PAH in SSc, and investigates associations between XOR, altered downstream metabolic pathways, and disease phenotypes and outcomes. Identifying XOR and oxidative stress as drivers of PAH pathogenesis would support XOR as a novel potential therapeutic target, thereby enabling more precise treatment of SSc-PAH.

PI_NAMEs: SIMPSON, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: activity marker;Address;Affect;Allopurinol;Animal Model;Apoptosis;biobank;Biochemical Reaction;Biological;Biological Assay;Biological Markers;Cause of Death;Cell Death;Cessation of life;Clinical;Clinical Data;clinical epidemiology;clinical phenotype;Clinical Research;Cluster Analysis;Complex;Data;Data Sources;Dedications;Development;Diagnosis;Disease;Disease Outcome;disease phenotype;Disease Progression;disorder risk;Endothelial Cells;Endothelium;Ensure;Environment;Enzymes;Functional disorder;Future;Generations;hemodynamics;high risk;Human;hypertensive;Image;improved outcome;Infrastructure;insight;Link;Longitudinal cohort;Lung;Measures;Mentors;Metabolic;Metabolic Marker;Metabolic Pathway;Metabolism;metabolomics;Methods;Modeling;Molecular Biology;Molecular Epidemiology;Morbidity - disease rate;mortality;new therapeutic target;Newly Diagnosed;novel;novel marker;Outcome;outcome prediction;oxidative damage;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;Pattern;Phenotype;pre-clinical;prevent;Productivity;Progressive Disease;prospective;Prospective cohort;Prospective, cohort study;Proteins;pulmonary arterial hypertension;pulmonary vascular disorder;purine metabolism;Purines;Reactive Oxygen Species;Research;Research Personnel;Research Project Grants;response;Right Ventricular Dysfunction;right ventricular failure;right ventricular remodeling;Role;Sampling;Scleroderma;Serum;Severity of illness;Signal Transduction;skills;success;Surrogate Markers;Survivors;Systemic Scleroderma;Therapeutic;therapeutic target;Time;Training;Translational Research;United States National Institutes of Health;unsupervised clustering;Uric Acid;Vasomotor;Ventricular;Work;XDH gene

PROJECT_TITLE: The role of xanthine oxidoreductase activity and altered metabolism in scleroderma-associated pulmonary arterial hypertension

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Transplantation

ORG_CITY: LOWELL

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

PHR: NARRATIVE Currently available synthetic grafts are unable to mimic the characteristics of vascularized bone or readily induce biomineralization. The proposed work develops oxygen-generating protein-based hydrogels to create highly vascularized and mineralized 3D constructs. These novel hybrid biomaterials represent a first step towards creating functional vascularized bone in physiologically-relevant sizes, therefore, they will improve regeneration of mineralized craniofacial tissues and enhance human health.

PI_NAMEs: CAMCI-UNAL, GULDEN  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: 3-Dimensional;Address;Affect;Aging;Animal Model;Autologous Transplantation;Biocompatible Materials;biodegradable scaffold;Biodegradation;Biological;biomaterial compatibility;biomineralization;bioscaffold;bone;bone cell;Bone Formation Stimulation;bone healing;Bone Regeneration;bone repair;bone scaffold;Bone Tissue;Bone Transplantation;Calcium;Calvaria;Cartilage;cell behavior;Cell Differentiation process;cell growth;Cell Survival;Cells;Cephalic;Characteristics;chemical property;Chemicals;clinically relevant;Coculture Techniques;combat;Congenital Abnormality;cost;craniofacial;Craniofacial Abnormalities;craniofacial repair;craniofacial tissue;craniomaxillofacial;Data;Defect;Dental;Development;Encapsulated;Endothelial Cells;Engineering;Excision;Exhibits;experience;experimental study;Gelatin;Gene Expression Profiling;Generations;Goals;graduate student;graft healing;healing;Health;Human;Hybrids;hydrogel scaffold;Hydrogels;Hydrophobicity;Immune;immunogenic;Immunohistochemistry;immunoreaction;Implant;implant material;implantation;improved;improved outcome;In Vitro;in vivo;Infection;infection risk;Injury;injury recovery;innovation;Kinetics;Knowledge;Lesion;mechanical properties;Mechanics;Metabolism;Methods;microCT;mineralization;Modeling;Morbidity - disease rate;Natural regeneration;novel;novel strategies;Osteoblasts;Osteogenesis;osteogenic;Oxygen;particle;patient population;Patients;Performance;Peroxides;physical property;Physiological;Polymers;Porosity;Predisposition;Property;Proteins;Protocols documentation;Rattus;Recovery of Function;repaired;replacement tissue;Research;response;restoration;scaffold;Site;Solid;Source;subcutaneous;Testing;Time;Tissue Engineering;Tissue Grafts;tissue regeneration;tissue repair;Tissues;Training;Translating;Trauma;tumor;Vascularization;Work;wound

PROJECT_TITLE: Scaffolds with high oxygen content for mineralization

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ORG_CITY: INDIANAPOLIS

ORG_DEPT: CHEMISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Project Narrative This research proposal seeks to develop transition-metal-free technologies that enable the modification and synthesis of molecules of interest to human health. Given regulatory requirements around the use of metals in the synthesis of pharmaceuticals, the development of metal-free strategies has the potential of significantly reduce drug-manufacturing costs and increase their safety. The primary impact of this proposal will be a greater understanding of these transformations and the development of new synthetic methods that greatly improve access to compounds that benefit society.

PI_NAMEs: LAULHE, SEBASTIEN  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Harnessing Electron-Donor-Acceptor Complexes to Enable Photo-Induced Metal-Free Cross-Coupling Reactions


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE For the tens of millions of patients who receive general anesthesia every year, it is still unclear why some patients experience peri-anesthetic complications while other patients that receive seemingly identical anesthetics have an uneventful perioperative course. In order to be able to tailor an anesthetic to the needs of an individual patient, we plan to investigate individualized measures of response to anesthetics, and the neural pathways that can affect those individual differences. We propose to investigate how the major adrenergic center of the brain, the locus coeruleus, changes one of those individualized measures, how stable a patient is in the awake or anesthetized state.

PI_NAMEs: MCKINSTRY-WU, ANDREW RICH (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Address;Adrenergic Agents;Affect;Anesthesia procedures;Anesthetics;Anxiety Disorders;Arousal;awake;Behavioral;Brain;Caring;Cognition;Cognitive;cognitive function;Computing Methodologies;Conscious;cost;density;Dose;drug sensitivity;Electroencephalography;experience;General Anesthesia;Genetic;genetic approach;Goals;Impaired cognition;Impairment;Individual;Individual Differences;individual patient;individual response;Investigation;Life;locus ceruleus structure;Measures;Methods;Monitor;Mus;Neural Pathways;Neurons;neurophysiology;Neurotransmitters;Operative Surgical Procedures;Pathway interactions;Patients;Perioperative;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacology Study;population based;Post-Traumatic Stress Disorders;postoperative delirium;Resistance;response;Role;System;Time;Unconscious State

PROJECT_TITLE: Personalized Anesthesia: The Role of the Locus Coeruleus in Individual Anesthetic Responses


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative: Vascular senescence due to DNA damage is an emerging characteristic feature seen in atherosclerosis and other chronic disease states, an effect that may promote disease progression leading to heart attack, stroke, or peripheral vascular disease. We identified an endothelial-enriched microRNA (miRNA) that is dynamically expressed with atherosclerosis in young and old mice, and may act to control lesion formation within the vessel wall by controlling DNA damage and cell senescence. The proposed studies will provide a detailed understanding underlying the function of this miRNA, its target genes and interactomes, and how to restore its expression therapeutically with the goal of developing novel miRNA-based therapies for the treatment of vascular senescence and atherosclerotic cardiovascular disease.

PI_NAMEs: FEINBERG, MARK W (contact)

PROGRAM_OFFICER_NAME: KIRBY, RUTH

PROJECT_TERMS: Adenosine;ADORA3 gene;Age;Aging;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Bioinformatics;Biology;Bioluminescence;Blood Vessels;Cardiovascular system;Cell Adhesion Molecules;Cell Aging;Cell Communication;Cell Physiology;cell type;Cessation of life;Characteristics;chemokine;Chronic;Chronic Disease;Coronary Arteriosclerosis;crosslinking and immunoprecipitation sequencing;cytokine;Development;Disease;Disease Progression;DNA Damage;Endothelial Cells;Endothelium;Foundations;frontier;Functional disorder;Genes;Goals;Grant;Human;Hyperlipidemia;in vivo;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Inherited;inhibitor;insight;intravital microscopy;Knockout Mice;Lesion;Leukocytes;Link;MADH3 gene;MAP Kinase Gene;MAPK8 gene;Mediating;MicroRNAs;Molecular;molecular imaging;Morbidity - disease rate;mortality;multidisciplinary;Mus;Mutation;Myocardial Infarction;nanomedicine;nanoparticle;Nodal;novel;novel therapeutic intervention;old mice;overexpression;Pathway interactions;Peripheral Vascular Diseases;posttranscriptional;Process;promoter;Proto-Oncogene Proteins c-akt;Regulation;Reporter Genes;Research;response;Risk Factors;Role;senescence;senescence associated secretory phenotype;Signal Pathway;Signal Transduction;single cell ATAC-seq;Societies;Specimen;Stimulus;Stroke;Therapeutic;therapeutic miRNA;Tissues;transcriptome sequencing;Untranslated Regions;Untranslated RNA;Vascular Cell Adhesion Molecule-1;Vascular Diseases;Vascular Endothelium;vascular inflammation

PROJECT_TITLE: miR-181b, endothelial cells, and vascular inflammation

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Aging

ORG_CITY: NEW YORK

ORG_NAME: AMERICAN FEDERATION FOR AGING RESEARCH

PHR: Project Narrative – Nathan Shock Centers Coordinating Center The Coordinating Center will establish a system of coordination and communication between the Nathan Shock Centers, the National Institute on Aging, and the biology of aging research community that maximizes the Nathan Shock Centers’ strengths, supporting integrated scientific research approaches that enhance the impact of those activities and broadcast their availability to the larger research community as well as to the general public. This will contribute to our understanding of the biology of aging, and accelerate innovations that will help us live longer, healthier.

PI_NAMEs: AUSTAD, STEVEN N.;LEDERMAN, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Acceleration;Advisory Committees;age-related disease;Aging;aging related;American;Automobile Driving;Award;Biology of Aging;Biomedical Research;Capital;career development;Code;Collaborations;Communication;Communications Media;Communities;Data;Databases;Dedications;Education and Outreach;Educational workshop;effectiveness evaluation;Electronic Mail;Electronics;Evaluation;Event;experience;Funding;Future;General Population;Geriatrics;Goals;Grant;Grant Review;healthy aging;Individual;Infrastructure;innovation;International;Joints;Knowledge;Leadership;Link;Location;Medical;meetings;Mission;National Institute on Aging;news;Newsletter;Nonprofit Organizations;Outcome;outreach;Physicians;posters;preclinical study;Printing;Privatization;pro-aging;Program Evaluation;programs;Reporting;Reproducibility;Research;Research Personnel;Resources;Role;Schedule;Science;scientific organization;Scientist;Shock;Site;social media;spelling;Surveys;symposium;synergism;System;Training;United States National Institutes of Health;Update;web site;webinar;Work


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: CHARLESTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE: Stroke is a number one cause of long-term disability in the United States, affecting approximately 6.6 million Americans, with a total projected cost of $2.2 trillion from 2005 to 2050. Following a stroke, more than two-thirds end up with a disability in the upper limb that lowers the ability to perform many daily activities, including self-care, vocations, and leisure, thus diminishing the quality of life. This project aims to evaluate a new technology in enhancing hand functional recovery following stroke, thereby improving independence and quality of life, with a cost-effective method.

PI_NAMEs: SEO, NA JIN  (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Accelerometer;Action Research;Activities of Daily Living;Address;Affect;American;arm;Biomechanics;Brachial Paresis;Caregiver Burden;chronic stroke;Clinical;clinical practice;Communication;Control Groups;cost;cost effective;Data;Devices;dexterity;Digit structure;disability;Dose;Double-Blind Method;Electric Stimulation;Electroencephalography;Esthesia;Esthetics;Evaluation;Feedback;finger movement;Fingers;follow-up;Frequencies;functional independence;Future;grasp;Hand;hand dysfunction;Hand functions;hand rehabilitation;improved;innovation;Intervention;Leisures;Lifting;Literature;Location;Long term disability;longitudinal analysis;Lower Extremity;Manipulative Therapies;Manuals;Measures;Mechanoreceptors;Methods;Modality;Motion;Motor;Motor Activity;Motor Cortex;motor impairment;Movement;neural;Neurons;new technology;novel;novel marker;Outcome;Outcome Measure;Paresis;Participant;Patient Compliance;Patient-Focused Outcomes;Peripheral;Pilot Projects;post intervention;post stroke;programs;Quality of life;Randomized;randomized, controlled study;Randomized, Controlled Trials;Recovery of Function;Research;Research Design;Rest;Risk;secondary analysis;Self Care;Sensory;Skin;smart watch;Standardization;Stroke;stroke survivor;Testing;Therapeutic;Time;translational potential;Translations;Treatment Efficacy;treatment group;United States;Upper Extremity;vibration;Vocation;Wrist

PROJECT_TITLE: Concomitant sensory stimulation during therapy to enhance hand functional recovery post stroke

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence

ORG_CITY: Newark

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project narrative Selective and rapid transport of K+ ions across the cell membrane is controlled by potassium channels — trans- membrane proteins whose disfunction is linked to cardiac arrhythmias, epilepsies, and other channelopathies. Multidimensional ultrafast vibrational spectroscopy is a powerful technique for studying structure and dynamics of proteins. The proposed research will provide novel machine-learning-based framework for simulating vibrational spectra of proteins which will help interpret and design vibrational spectroscopy experiments aiming at elucidating the molecular underpinnings of activation, conduction, and selectivity of ion channels.

PI_NAMEs: KANANENKA, ALEXEI  (contact)

PROJECT_TERMS: Arrhythmia;Cardiovascular Diseases;Cell membrane;chemical bond;complex biological systems;Computing Methodologies;Data;data-driven model;design;Dimensions;Disease;electric field;Environment;Epilepsy;experimental study;Frequencies;frontier;Functional disorder;Future;Goals;graph neural network;improved;Integral Membrane Protein;Ion Channel;Ion Transport;Ions;Light;Link;machine learning framework;magnetic field;Maps;Measures;Methodology;Methods;Modeling;Molecular;Molecular Conformation;Myopathy;Nervous System Disorder;NMR Spectroscopy;novel;Nuclear;Peptides;Physiologic pulse;Potassium Channel;programs;Protein Dynamics;Proteins;Research;simulation;Solvents;Spectrum Analysis;Structural Models;Structure;System;Techniques;temporal measurement;therapeutic target;two-dimensional;Vertebral column;vibration;voltage;X-Ray Crystallography

PROJECT_TITLE: Data-driven modeling of the vibrational spectroscopy of ion channels


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Several fundamental insights on how synapses of auditory neurons operate in the developing and mature mammalian brainstem will be obtained from the proposed studies. This information sheds light on cellular mechanisms for binaural hearing including sound localization and enlightens current and future treatment strategies of hearing disorders. These studies will lead to an improved understanding of directional hearing in maturing animals and in future studies of how deficits in auditory brainstem synaptic transmission contribute to hearing loss.

PI_NAMEs: VON GERSDORFF, HENRIQUE PRADO (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: 3-Dimensional;Action Potentials;Adult;Age Months;Auditory;auditory pathway;Axon;Binaural;binaural hearing;biophysical analysis;biophysical model;Biophysical Process;biophysical properties;Brain Stem;Buffers;Cell Nucleus;Cells;channel blockers;Cochlear nucleus;Computer Models;Confocal Microscopy;Contralateral;Coupled;Coupling;Crowding;Data;Development;Diffusion;Docking;Ear;Egtazic Acid;Electrodes;electron tomography;Exhibits;Exocytosis;Experimental Models;experimental study;Fire - disasters;Frequencies;Future;Glycine;Goals;Hearing;hearing impairment;Hearing problem;Heterogeneity;Image;improved;in vivo;insight;Invaded;Ions;Ipsilateral;Laser Microscopy;lateral superior olive;Link;Location;mature animal;Measures;Medial;Modeling;Mus;nano;Nerve;Neurons;Output;patch clamp;pharmacologic;Physiological;postnatal;postnatal development;postsynaptic;Potassium Channel;preservation;presynaptic;Presynaptic Terminals;Probability;reconstruction;recruit;Reporting;Research;Resolution;response;Slice;sound;sound frequency;Sound Localization;Spike Potential;Structure;Synapses;synaptic depression;Synaptic Membranes;Synaptic Transmission;Techniques;Testing;Time;Transgenic Mice;trapezoid body;treatment strategy;Vesicle;Visualization

PROJECT_TITLE: Modulation of Exocytosis and Excitability in Mature Auditory Brainstem Neurons


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Precision Medicine;Social Determinants of Health;Substance Misuse

PHR: Project Narrative While treatment effect heterogeneity is a concern in research of substance use disorder treatments, analysis of treatment effect heterogeneity has been often conducted in a suboptimal manner using subgroup analysis, which could result in finding spurious differences in treatment effects by subgroup due to the performance of multiple statistical tests and random variability across patients. Another challenge of subgroup analysis is that most covariates have small moderating effects and their individual contribution to treatment effect heterogeneity is not meaningfully informative to treatment decisions. This study will apply a novel statistical method, causal forest approach, to data from 12 randomized controlled trials of psychosocial treatments in the NIDA Clinical Trials Network to estimate the expected effect of a treatment for each individual while taking into account multiple covariates simultaneously and to identify the most important covariates contributing to treatment effect heterogeneity.

PI_NAMEs: SUSUKIDA, RYOKO  (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Abstinence;Acceleration;Address;Age;Algorithms;Clinical;Clinical Trials Network;clinically relevant;Data;Data Analyses;data harmonization;data sharing;Disease;drug abstinence;Drug abuse;Education;effectiveness evaluation;evidence base;exercise program;experience;Family psychotherapy;forest;Frequencies;Goals;Health Personnel;Heterogeneity;Incentives;Individual;individual patient;individual variation;Intervention;Measures;Methodology;Methods;Motivation;motivational enhancement therapy;National Institute of Drug Abuse;novel;Outcome;Participant;Patients;Performance;Persons;Phenotype;polysubstance use;precision medicine;prevent;Provider;psychiatric comorbidity;psychosocial;Randomized, Controlled Trials;Recovery;Research;response;Risk;Safety;screening;Severities;sex;shared repository;sociodemographics;Statistical Methods;Subgroup;substance use;Substance Use Disorder;substance use treatment;Symptoms;System;Techniques;Testing;Therapeutic;treatment as usual;treatment effect;Treatment outcome;treatment research;Work

PROJECT_TITLE: Treatment Effect Heterogeneity in Psychosocial Treatments for Substance Use Disorders


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Lung;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Severe alveolar epithelial damage is often observed in several types of human lung disease, including influenza infection, idiopathic pulmonary fibrosis (IPF), and COVID-19, however little is known about interactions within the cellular niche that contribute to aberrant or constructive regeneration. The purpose of this project is to leverage a biomimetic engineered lung tissue model to investigate the role of macrophages in alveolar regeneration. Overall, the findings of this work will identify mechanisms of epithelial repair governed by alveolar macrophages and their activation state, thereby suggesting possible routes for pharmacologic intervention for fibrotic lung diseases.

PI_NAMEs: GREANEY, ALLISON MARIE (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Air;Alveolar;Alveolar Cell;alveolar epithelium;Alveolar Macrophages;anti-cancer research;Anti-Inflammatory Agents;Apoptotic;Architecture;Basal Cell;Behavior;Benchmarking;Biological Models;Biomechanics;Biomedical Engineering;Biomimetics;Bronchoalveolar Lavage;Cell Communication;cell community;cell type;Cells;Cessation of life;Chemical Stimulation;Chemicals;Coculture Techniques;Communication;COVID-19;cytokine;Data;Dinoprostone;Disease;Disease Outcome;Distal;Endothelium;Engineering;Environment;Epithelial Cells;epithelial repair;epithelial stem cell;Epithelium;epithelium regeneration;Evaluation;Faculty;Fibroblasts;Fibrosis;fibrotic lung;fibrotic lung disease;Goals;Histologic;Homeostasis;Human;Hypoxemia;idiopathic pulmonary fibrosis;improved;In Vitro;in vivo;Inflammatory;influenza infection;Injury;insight;Institution;Interferon Type II;Interleukin-4;Intervention;Lavage;Lipopolysaccharides;Liquid substance;Lung;Lung Diseases;lung regeneration;lung repair;Macrophage;Maintenance;Massachusetts;Mentors;Mesenchymal;Mesenchyme;Methods;migration;muscle repair;Myoblasts;Myofibroblast;Natural regeneration;novel;organ growth;Paracrine Communication;Pattern;pharmacologic;Phenotype;Play;Population;Positioning Attribute;Production;progenitor;Proteins;Protocols documentation;Publishing;Rattus;recruit;regenerative;repaired;Reporting;Research;Research Project Grants;response;restoration;Role;Route;SARS-CoV-2 infection;scaffold;Secure;severe injury;Signal Transduction;single-cell RNA sequencing;Site;Skeletal muscle injury;skills;stem cells;Structure of parenchyma of lung;System;Technology;tenure track;Therapeutic Intervention;Tissue Model;Tissues;Training;Universities;Vascular Endothelium;Work

PROJECT_TITLE: The Role of Macrophages in Pulmonary Regeneration using a Bioengineered Whole Lung Tissue Model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Kidney Disease;Liver Disease;Organ Transplantation;Precision Medicine;Prevention;Transplantation

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Biomarkers in the blood can be used to detect signs of certain diseases to guide treatment strategies aimed at preventing them, and in the case of this application, rejection and kidney injury in liver transplant recipients. This project will test if the biomarkers we developed in a prior CTOT study can predict rejection and kidney injury and therefore help us use anti-rejection medications in a more successful way. This study will also provide a deeper understanding of the pathways that lead to rejection and kidney injury and improve our ability to avoid these complications.

PI_NAMEs: LEVITSKY, JOSH  (contact)

PROGRAM_OFFICER_NAME: HAYES, DEBORAH

PROJECT_TERMS: Acute;Antibodies;Benefits and Risks;biobank;Biological Markers;biomarker performance;biomarker signature;biomarker validation;Blood;Calcineurin inhibitor;Cells;Cellular Assay;Chronic Kidney Failure;Clinical;Clinical Data;clinical practice;Clinical Trials;cohort;Communities;Complication;Data;Decision Making;Deterioration;Diagnostic;Dialysis procedure;Disease;Drug toxicity;Early Diagnosis;effector T cell;Equilibrium;Excision;exhaustion;Fibrosis;FRAP1 gene;frontier;Future;Gene Expression;Generations;Genomics;Glomerular Filtration Rate;Graft Survival;high risk;Hypoxia;imaging biomarker;Immune;immune activation;Immune response;Immunosuppression;improved;inhibitor;inhibitor therapy;Injury to Kidney;insight;Intervention;Kidney;kidney imaging;kidney preservation;Kidney Transplantation;Liver;liver transplantation;loss of function;Magnetic Resonance Imaging;Modeling;molecular diagnostics;molecular marker;Monitor;mTOR Inhibitor;Multi-Institutional Clinical Trial;Multicenter Trials;nephrotoxicity;new therapeutic target;novel;Outcome;Pathway interactions;Patient Selection;patient stratification;Patients;Pharmaceutical Preparations;Phenotype;Physiological;Plasma Proteins;pre-clinical;predictive marker;preservation;prevent;primary endpoint;primary outcome;Property;prospective;proteogenomics;Proteomics;Randomized;Regimen;Regulatory T-Lymphocyte;Renal function;renal ischemia;Research;Resources;response;Risk;risk stratification;Role;sample collection;Sampling;Science;SDZ RAD;standard of care;Surface;T-Lymphocyte;Tacrolimus;technology platform;Testing;Therapeutic;Therapeutic immunosuppression;Time;Transplant Recipients;Transplantation;Transplanted Liver Complication;treatment strategy;validation studies;Weaning;Withdrawal;Work

PROJECT_TITLE: Utility of Biomarkers of Rejection and Kidney Injury in Tailoring Liver Transplant Immunosuppression


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: The proposed research is relevant to public health because it would implement a novel proof-of-principle experimental strategy to ameliorate Huntington’s disease (HD) onset and progression: innovative developmental cell transplantation approaches employing the wild-type counterpart of affected cortical interneuron progenitor cells to promote restoration of impaired cortico-striatal functions rather than traditional regenerative approaches to replace defective cell types during the active phase of the disease. Accordingly, this research addresses a knowledge gap that is relevant to the goals of the overall NIH strategic mission, namely the absence of understanding of the requisite HD developmental targets and mechanisms amenable to disease-modifying interventions for neurodegenerative diseases. By targeting early cellular maturational impairments that promote late-onset disease, this approach will enhance the restoration of neural network functions during the critical period of developmental plasticity and the pre-manifest phase of illness prior to the onset of irrevocable disease dysfunction.

PI_NAMEs: MEHLER, MARK F (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Ablation;Address;Adult;Affect;Age;age related;Allografting;Animal Model;Autopsy;Behavioral;Brain;Brain region;Cell Transplantation;cell type;Cells;Cerebral cortex;Characteristics;Clinical;Code;Complement;Corpus striatum structure;Coupling;critical developmental period;critical period;Data;Development;developmental disease;developmental plasticity;Developmental Process;Disease;disease model;Disease Progression;DNA Damage;effectiveness evaluation;Effectiveness of Interventions;Embryo;Event;excitotoxicity;Exons;experimental study;Exposure to;Foundations;Functional disorder;gamma-Aminobutyric Acid;Genes;Genetic;genetic approach;Genetic Diseases;Genetic Polymorphism;Goals;Human;Huntington Disease;Huntington gene;Impairment;innovation;insight;Interneurons;Intervention;intervention effect;Knowledge;Laboratories;Laboratory Study;Late-Onset Disorder;Lead;Length;Life;Ligands;Link;Literature;Mediating;Mission;Motor;motor deficit;motor disorder;motor impairment;mouse model;Mus;mutant;Neonatal;neural network;Neurodegenerative Disorders;neurogenesis;neuroimaging;neuropathology;New York;novel;Nucleotides;Onset of illness;Outcome;Output;Pathogenesis;Pathogenicity;Pathologic;Pathology;Phase;postnatal;postnatal period;preclinical study;Predictive Value;prevent;Prevention;Public Health;pup;receptor;regenerative approach;Reporting;Research;response;restoration;Role;Specimen;stem cells;Stress;Supplementation;System;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;trait;Transplantation;Trinucleotide Repeat Expansion;Trinucleotide Repeats;United States National Institutes of Health;Universities;white matter

PROJECT_TITLE: Interneurons as Early Drivers of Huntington´s Disease Progression

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Brain Disorders;Estrogen;Neurosciences;Women's Health Research

PHR: PROJECT NARRATIVE The goal of this project is to determine whether estradiol directly impacts astrocyte signaling in the nucleus accumbens. This would ultimately impact synaptic neurotransmission and motivated behaviors. Recent studies have determined sex and hormonal effects within the nucleus accumbens, and estrogen signaling in astrocytes may underlie many of these observations.

PI_NAMEs: GOENAGA, JULIANNA G (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: addiction;Affect;Animal Behavior;Area;Astrocytes;Behavior;Binding;Biological Assay;Brain;Brain region;Calcium;calcium indicator;Calcium Signaling;career;cell type;Cells;Communication;Data;Dendritic Spines;density;Diestrus;Drug Addiction;drug seeking behavior;Electrophysiology (science);Estradiol;Estrogen Receptors;Estrogens;experimental group;experimental study;Female;Glutamates;Goals;Gonadal Hormones;Gonadal Steroid Hormones;Hormonal;Hormones;Image;In Situ;Knowledge;Location;male;Measures;Mediating;Membrane;Molecular;Monitor;motivated behavior;Mus;Nervous System Physiology;Neurons;Neurosciences;neurotransmission;neurotransmitter antagonist;Neurotransmitter Receptor;Neurotransmitters;novel;Nucleus Accumbens;patch clamp;pharmacologic;Phase;Physiology;Play;postsynaptic;Process;Proestrus;receptor;Receptor Activation;receptor binding;Regulation;release of sequestered calcium ion into cytoplasm;Reporting;Research;Research Personnel;Research Technics;response;Rewards;Role;selective expression;sex;Sex Differences;Signal Transduction;Signaling Molecule;Slice;Synapses;Synaptic Transmission;Techniques;Testing;Transgenic Mice;Transgenic Organisms;two photon microscopy;two-photon;Whole-Cell Recordings

PROJECT_TITLE: Estrogen Signaling in Nucleus Accumbens Astrocytes


ORG_CITY: TOWSON

ORG_NAME: TOWSON UNIVERSITY

PHR: NARRATIVE In light of the positive impact of workforce diversity on innovation in biomedical research and addressing public health, achieving a biomedical workforce that reflects the increasing diversity of the US population is essential to meet growing science and technology demands; however, individuals from underrepresented groups comprise a small percentage of the doctoral level biomedical workforce. Towards the goal of increasing workforce diversity, the Bridges to the Doctorate (B2D) partnership between Towson University (TU), the University of Maryland School of Medicine (UMSOM), and Johns Hopkins School of Medicine (JHUSOM) will create a supportive minority-focused training program in which students gain critical research and professional experience while completing their Master’s degree at TU. The TU-UMSOM-JHUSOM B2D training program will prepare students for the successful transition from MS to PhD programs and completion of the doctorate at UMSOM, JHUSOM, and other institutions nationwide, thus increasing representation in the biomedical profession and enhancing diversity in this workforce.

PI_NAMEs: EHRLICH, ELANA S (contact);HASSEL, BRET A;SNYDER, MICHELLE LYNN DYKSTRA;ZARIF, JELANI CHINELO

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: bridge to the doctorate;Universities

PROJECT_TITLE: Bridges to the Doctorate at Towson University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Aging;Cardiovascular;Contraception/Reproduction;Estrogen;HIV/AIDS;Heart Disease;Infectious Diseases;Menopause;Microbiome;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Cardiovascular disease is a major concern in post-menopausal women, and particularly post-menopausal women with HIV. Our study focusing on menopause, sex hormones, and the gut microbiome has the potential to reveal novel mechanisms of cardiovascular risk in HIV-infected and uninfected women. This research can ultimately lead to new therapies targeting the gut microbiome, to lower CVD risk in post-menopausal women with or without HIV.

PI_NAMEs: PETERS, BRANDILYN A (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: 16S ribosomal RNA sequencing;Adrenal Glands;Age;Androgens;Area;Award;Bacteria;Bioinformatics;Biological Assay;Biological Markers;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;career;career development;Carotid Artery Plaques;CD14 gene;Chronic Disease;Clinical Data;Clinical Research;Clinical Trials;cohort;Cohort Studies;Communities;Data;Disease;Disease Progression;dysbiosis;Estradiol;Estrogens;Face;Feces;Future;General Population;Glucuronides;Gonadal Steroid Hormones;Grant;gut microbiome;gut microbiota;high risk;HIV;HIV Infections;Hormonal;hormone therapy;Human;Immune;Individual;intimal medial thickening;Link;Mass Spectrum Analysis;Measurement;Measures;men;Menopausal Status;Menopause;Menstruation;Metabolic;metagenomic sequencing;microbial;microbiome;microbiome composition;microorganism;Modeling;mortality;Mucosal Immunity;new therapeutic target;novel;Operations Research;ovarian reserve;Pathogenesis;Perimenopause;Persons;Phenotype;Plasma;Population;Postmenopause;Premenopause;Prevotella;Reproductive Endocrinology;Research;Sampling;Science;Serum;sex;Shotgun Sequencing;Shotguns;skill acquisition;Statistical Methods;stool sample;Testosterone;Therapeutic Intervention;Training;ultrasound;Woman;Women's Interagency HIV Study;Women's study

PROJECT_TITLE: Menopause and hormonal influences on the gut microbiome for CVD risk in HIV

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Hematology;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE We will develop new novel gene transfer strategies into bone marrow cells for more effective treatment of hemophilia A by optimizing lentiviral constructs, delivering the constructs by intraosseous (IO) or intranasal (IN) delivery to transduce bone marrow cells targeting platelet-specific expression of factor VIII, and examining the therapeutic effect following gene transfer. We demonstrated previously that IO delivery of lentiviral vectors will transduce human bone marrow cells efficiently and in vivo hematopoietic stem cell gene therapy will provide long-term therapeutic benefit in hemophilia A mice. In the current study, we would like to enhance the safety and efficacy of this new novel strategy in hemophilia A mice and dogs with or without pre-existing inhibitors; these comprehensive studies will pave the way for the development of this novel technology for human applications.

PI_NAMEs: MIAO, CAROL H (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Abbreviations;Alpha Granule;Antibodies;Biomedical Engineering;Bispecific Antibodies;Blood coagulation;Blood Platelets;Bone Marrow;Bone Marrow Cells;Bypass;Canis familiaris;Cell Culture Techniques;Cell Separation;Cells;Clinical;Clinical Trials;Complication;cost;Data;delivery vehicle;Development;Disease susceptibility;Dose;effective therapy;efficacy evaluation;Engraftment;Ensure;Erythropoiesis;Factor VIII;Factor Xa;gene therapy;Gene Transduction Agent;Gene Transfer;gene-targeted therapy;Genes;Hematopoietic stem cells;Hemophilia A;Hemorrhage;Hemostatic Agents;Human;Immune response;Immune system;Immune Tolerance;improved;In Situ;in vivo;Infusion procedures;inhibitor;Injury;integration site;Lentivirus Vector;Mediating;Megakaryocytes;Morbidity - disease rate;mouse model;Mus;neutralizing antibody;new technology;novel;novel strategies;novel therapeutics;Patients;Pattern;pediatric patients;Pharmaceutical Preparations;Phenotype;Plasma;Platelet Activation;preconditioning;Production;promoter;Proteins;Protocols documentation;Quality of life;Reagent;Risk;Safety;side effect;Site;Stem Cell Factor;stem cell gene therapy;Therapeutic;Therapeutic Effect;Thrombocytopenia;Toxic effect;transduction efficiency;Transgenes;Transgenic Mice;Variant;Viral

PROJECT_TITLE: Intraosseous delivery of lentiviral vectors for hemophilia A gene therapy