NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Liver Disease;Organ Transplantation;Patient Safety;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE . The proposed research serves public health with its novel focus to improve pediatric liver transplant outcomes by assessing and intervening on children’s underlying health-related social risks, e.g., material economic hardship, social isolation, caregiver mental health, health literacy, and neighborhood characteristics. Integrating a Health Advocate as a member of the post-transplant care team will support the delivery of interventions to overcome barriers interposed by these social risks, with clear potential to close disparities and significantly improve long-term outcomes for these children. The proposed research is directly relevant to NIDDK’s vision to seek insights and answers to bridge health disparities.

PI_NAMEs: WADHWANI, SHARAD  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;Adherence;adverse outcome;Advocate;Award;Behavior;Blood Glucose;blood glucose regulation;California;career development;Caregivers;Caring;Cessation of life;Characteristics;Child;Child Care;Childhood;Childhood diabetes;Chronic Disease;Clinic;Clinical;Clinical Trials Design;cohort;Collaborations;Communities;comorbidity;Complex;Data;data registry;deprivation;design;Development Plans;Disparity;Documentation;economic disparity;Economics;efficacious intervention;efficacy testing;end stage liver disease;Enrollment;Ensure;Environment;Ethnography;Family;food insecurity;Foundations;Funding;Future;Goals;graft failure;Graft Survival;Health;health disparity;Health education;health literacy;Health Services;Health system;Hepatology;high risk;Household;Immunosuppression;implementation evaluation;implementation science;improved;improved outcome;Individual;insight;Intervention;intervention delivery;Interview;Knowledge;Life;Link;liver transplantation;low health literacy;Malignant Neoplasms;Measurement;Measures;Medical;medication compliance;medication nonadherence;member;Mental Health;Mentored Patient-Oriented Research Career Development Award;Methodology;Methods;Modeling;Morbidity - disease rate;Motivation;Multi-Institutional Clinical Trial;Multicenter Studies;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Neighborhoods;novel;Nurses;Outcome;Outcome Assessment;Outcome Measure;outcome prediction;Parents;Patient Care;Patients;Pediatrics;Persons;Physicians;Population;post-transplant;Practice Management;Primary Care;primary outcome;Procedures;Process;professor;prospective;Prospective cohort;Provider;provider communication;Psychosocial Assessment and Care;Public Health;Publishing;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Regimen;Reporting;Research;Research Design;Research Infrastructure;Research Personnel;Research Support;Resources;Risk;Risk Factors;risk mitigation;risk prediction;Role;San Francisco;satisfaction;Self Management;skill acquisition;skills;social;social adversity;social health determinants;Social isolation;Social support;Social Workers;Societies;socioeconomics;stakeholder perspectives;Structure;Supervision;Survey Methodology;Surveys;Testing;theories;Time;Training;transplant centers;transplant registry;Transplantation;Universities;virtual;Vision;Visit

PROJECT_TITLE: Addressing social adversity to improve outcomes among children undergoing liver transplant: the role for a health advocate on the transplant team

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Recombineering-based no-cleavage gene-editing toolkit for large-scale genome engineering and functional screening As gene-editing tools help unravel mechanisms of biological process such as tissue development and human diseases such as cancer, a remaining challenge is that our current gene-editing tools are often limited to making small genome changes like single-nucleotide variants. The key bottleneck is the lack of efficient, safe, and robust tools to study large genome changes. Thus, it demands new modalities of genome engineering tools that we proposes to develop here, leveraging novel class of no-cleavage recombineering-based mechanisms, pushing our ability to engineer, track, and control cellular genomes and proteomes.

PI_NAMEs: CONG, LE  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Area;arm;Auxins;Bacteriophages;Benchmarking;biological adaptation to stress;Biological Assay;Biological Models;Biological Process;Bypass;cancer cell;Cell model;cell type;Cells;cellular engineering;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Codon Nucleotides;collaborative environment;Collection;CRISPR screen;CRISPR/Cas technology;Custom;Data;deep sequencing;delivery vehicle;Dependence;design;Development;DNA;DNA Damage;DNA Repair;DNA Repair Pathway;DNA-PKcs;Engineering;Enzymes;Eukaryotic Cell;Event;Exhibits;experimental study;forward genetics;gene editing technology;Gene Expression;Gene Expression Regulation;gene-editing approach;Generations;Genes;Genetic Engineering;Genetic Screening;Genome;Genome engineering;genome-wide;Genome-wide Unbiased Identification of DSBs Enabled by sequencing;Genomics;Goals;Guidelines;Human;human disease;Human Genome;improved;insertion/deletion mutation;Invaded;Knock-in;Lead;Length;Libraries;live cell imaging;Malignant Neoplasms;Mammalian Cell;Measures;Mediating;Metagenomics;Methods;Mining;Mission;Modality;Modeling;Modification;Mus;mutant;Mutation;National Institute of General Medical Sciences;novel;off-target site;plasmid DNA;Positioning Attribute;Procedures;Protein Engineering;protein function;Proteins;Proteome;Protocols documentation;Reagent;repaired;Reporter;Research;Ribonucleoproteins;screening;Screening procedure;Single Nucleotide Polymorphism;Site;Source;stem;stem cell model;success;System;technology development;technology validation;Testing;Tissues;tool;Toxic effect;TP53 gene;Transgenes;Untranslated RNA;Variant;Viral Vector;Work

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Clinical Research;Health Services;Mental Health

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Mental illness is a major public health concern in the United States and a significant source of morbidity and mortality. The goal of this program is to produce the next generation of researchers with rigorous training in health services research and economics, statistics and other methodologies, and implementation science, all applied to mental health, and with a deep understanding of how health services and care delivery systems might be optimally and equitably designed to serve the needs of persons with mental illness.

PI_NAMEs: EISENBERG, MATTHEW ;STUART, ELIZABETH A. (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Health system;Mental Health Services;Training Programs

PROJECT_TITLE: Mental Health Services and Systems Training Program


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative The biguanide drug metformin that is widely used for the management of Type 2 diabetes is being evaluated as an anti- neoplastic agent in cancer trials including GBM. In this proposal we will investigate molecular markers for metformin therapy and mechanisms of resistance to metformin therapy in glioblastoma.

PI_NAMEs: DASGUPTA, BIPLAB  (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: adenylate kinase;Algorithms;Antineoplastic Agents;Biguanides;blood-brain barrier crossing;Brain;Cell Death;cell growth;Cell Line;Cell membrane;Classification;classification trees;clinical development;Clinical Trials;cohort;Combined Modality Therapy;complement C2a;Complex;Data;Data Analyses;Diffusion;Dose;efficacy evaluation;efficacy study;efficacy testing;experimental analysis;FDA approved;Gene Expression;Generations;Genes;Glioblastoma;Glucose;Glycolysis;Goals;Growth;improved;In Vitro;in vitro testing;in vivo;inhibitor;inhibitor therapy;Investigation;Kidney;kinase inhibitor;Knowledge;Liver;Malignant neoplasm of lung;Malignant Neoplasms;Messenger RNA;Metabolic;metabolic phenotype;Metformin;Methods;Methylation;Mitochondria;Molecular;Molecular Analysis;molecular marker;mouse model;Mutation;neoplastic cell;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Oral;Osmosis;Outcome;Oxidative Phosphorylation;Pathway interactions;Penetration;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;promoter;protein expression;Proteomics;Pump;Pyruvate;pyruvate dehydrogenase;regression trees;Regulation;Resistance;resistance mechanism;responders and non-responders;response;Safety;safety study;sensor;Signal Transduction;Specificity;Stable Isotope Labeling;stem;stem cells;success;temozolomide;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Effect;therapy resistant;Tissues;Toxic effect;Translating;tumor;tumor growth;tumor microenvironment;Tumor Subtype;Validation

PROJECT_TITLE: Mechanisms of Biguanide Sensitivity in GBM

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Lung;Orphan Drug;Patient Safety;Precision Medicine;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative We will perform a genotype driven trial assessing the efficacy of NAC in patients with TOLLIP rs3750920 T/T genotype. We will also molecularly endophenotype all patients with IPF and ILD in the PFF biospecimen repository using whole genome sequencing, RNA sequencing and proteomics.

PI_NAMEs: MARTINEZ, FERNANDO J (contact);NOTH, IMRE

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acetylcysteine;Address;Algorithms;antifibrotic treatment;biobank;Biological;Biological Specimen Banks;Blood;Classification;Clinical;clinical care;Clinical Data;clinical research site;cohort;Collection;combinatorial;comparative efficacy;Consent;Data;Data Collection;Diagnosis;Diagnostic;Disease;disease diagnosis;Disease Management;disorder risk;Double-Blind Method;effective therapy;efficacy evaluation;endophenotype;Enrollment;Ethnic Origin;Exhibits;experimental study;Exposure to;fibrotic interstitial lung disease;Foundations;Gene Expression;Gene Frequency;Gene Proteins;Genes;Genetic;genetic association;genetic variant;genome sequencing;genome-wide analysis;Genotype;Goals;Hospitalization;idiopathic pulmonary fibrosis;improved;Individual;innovation;insight;Interstitial Lung Diseases;Lead;Link;Longitudinal cohort;Lung Transplantation;member;Minor;Molecular;Molecular Disease;molecular marker;mortality;Nature;novel;Outcome;Participant;patient subsets;Patients;Pharmacogenetics;Pharmacogenomics;Phenotype;Physiological;Placebos;Population;precision medicine;primary endpoint;Process;Prognosis;prognostic;Prognostic Marker;prospective;protein biomarkers;Proteomics;Pulmonary Fibrosis;Quantitative Trait Loci;Randomized;Recontacts;recruit;Registries;Reproducibility;Research Design;respiratory;Risk;sample collection;Sampling;Site;success;Survivors;synergism;Testing;Therapeutic;Therapeutic Trials;time use;TOLLIP gene;trait;transcriptome sequencing;transcriptomics;treatment arm;Treatment Efficacy;treatment response;Variant;whole genome

PROJECT_TITLE: 1/2 Prospective tReatment EffiCacy in IPF uSlng genOtype for Nac Selection (PRECISIONS) trial and Molecular Endophenotyping in Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases study

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Diabetes;Health Services;Heart Disease;Prevention

PHR: The goal of this project is to provide support for mentoring and research in the clinical epidemiology of cardiovascular disease and type 2 diabetes. Dr. Selvin has a strong track record of success in the field and in mentoring junior scientists. With support from this K24, Dr. Selvin will be able to continue her mentorship activities, strengthen her research portfolio, and recruit and train the next generation of leaders in the field.

PI_NAMEs: SELVIN, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Acute;Address;Appointment;Area;Award;Biological Markers;Biometry;Blood Vessels;Budgets;Cardiac;Cardiology;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder prevention;cardiovascular risk factor;Cardiovascular system;career;career development;Caring;Cessation of life;Chronic;Circulation;Clinical;Clinical Chemistry;clinical decision-making;clinical epidemiology;Clinical Research;Collaborations;collaborative environment;Dedications;design;Diabetes Mellitus;Discipline of Nursing;disorder prevention;Doctor of Philosophy;Educational Status;Endocrinology;Environment;Epidemiologic Methods;Epidemiology;epidemiology study;evidence base;Faculty;faculty mentor;Funding;Genomics;Goals;Grant;Health;Health Promotion;Hyperglycemia;Imaging technology;Impaired cognition;improved;Internal Medicine;Journals;K-Series Research Career Programs;Knowledge;late life;Manuscripts;Master of Science;medical schools;member;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);Monitor;Morbidity - disease rate;mortality;multidisciplinary;Neurology;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;optimal treatments;patient oriented;patient oriented research;Persons;physical impairment;Pilot Projects;Prediabetes syndrome;prevent;Prevention;Prevention Research;programs;Proteomics;Public Health;Public Health Schools;Publications;Publishing;randomized, clinical trials;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Risk;Role;School Nursing;Scientific Advances and Accomplishments;Scientist;screening;Serum;success;Talents;Time;tool;Training;Training Activity;Translational Research;United States National Institutes of Health

PROJECT_TITLE: Research and Mentoring in the Clinical Epidemiology of Cardiovascular Disease and Type 2 Diabetes

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: MO

PHR: Project Narrative  Craniofacial anomalies account for a high proportion of human congenital birth defects which dramatically impact national health care budgets, and despite multiple surgeries, rarely are fully corrected. It is therefore critical to develop therapies for improved prognosis and prevention, and this research proposal will elucidate novel fundamental cellular genetic mechanisms regulating neural crest cell and early craniofacial development.

PI_NAMEs: ZAJIC, EMMA  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Actins;Address;Affect;Automobile Driving;Basal Cell;Biophysical Process;Birds;Body System;Budgets;Cells;Cephalic;Chemicals;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial development;craniofacial disorder;craniofacial tissue;Crowding;Cytoskeletal Proteins;Cytoskeleton;Data;Development;Disease;Embryo;Embryonic Development;Environment;Epithelium;Etiology;Evolution;gain of function;gene regulatory network;Generations;Genes;Genetic;Healthcare;Heterozygote;Human;improved;Individual;inhibitor;innovation;Ion Channel;Knock-out;Knowledge;loss of function;Mammals;Measures;Mediating;Mesenchymal;Microtubules;migration;Molecular;Morphology;Mus;Mutation;Neural Crest Cell;Neuroepithelial Cells;neuroepithelium;neuroimaging;Nonmuscle Myosin Type IIA;novel;Operative Surgical Procedures;Pathogenesis;Phase;Piezo 1 ion channel;Play;Prevention;Preventive therapy;Process;Prognosis;Regulation;Research;Research Proposals;Role;Signal Pathway;single-cell RNA sequencing;Skeleton;spatiotemporal;Specific qualifier value;stem cell population;Stretching;System;Testing;therapy development;Tissues;transcription factor;transcriptomics;Visualization

PROJECT_TITLE: The regulation and cellular dynamics of neural crest cell delamination in mammalian craniofacial development

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative: The proposed research is relevant to public health because it will advance our understanding of the molecular mechanisms by which individual molecules, multimolecular assemblies and subcellular structures detect, withstand and respond to force, such as during chromosome segregation or neuronal plasticity. The proposed research is in line with NIH's mission to foster fundamental creative discoveries that would ultimately advance our capacity to protect and improve human health.

PI_NAMEs: GRISHCHUK, EKATERINA L (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Aneuploidy;aurora B kinase;Automobile Driving;Binding;Binding Proteins;Biological Assay;Biomechanics;biophysical analysis;Cell division;Cells;Centromere;Chemicals;Chimeric Proteins;Chromatin;Chromosome Segregation;Chromosomes;Closure by clamp;Complex;Creativeness;Diffusion;Equipment;Exhibits;experience;flexibility;Fostering;Friction;Genomic Instability;Health;Hela Cells;Human;improved;in vitro Assay;Individual;innovation;insight;Kinetochores;Knowledge;Macromolecular Complexes;Mechanics;Microtubule-Associated Proteins;Microtubules;Mission;Mitotic;Molecular;molecular assembly/self assembly;Molecular Machines;molecular mechanics;Motility;Motion;Motor Activity;Neuronal Plasticity;novel strategies;operation;particle;Pattern;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;prevent;Process;Property;Proteins;Public Health;Regulation;Research;Role;scaffold;segregation;Shapes;single molecule;spatiotemporal;Spectrum Analysis;Subcellular structure;System;Testing;Theoretical model;Time;tool;Travel;United States National Institutes of Health;Weight-Bearing state;Work

PROJECT_TITLE: Biomechanics of molecular machines and multiscale non-linear systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Urologic Diseases

ORG_CITY: DALLAS

ORG_DEPT: UROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Narrative Understanding the role of stromal-epithelial interactions in the etiology of BPH is key to the development of new therapeutics. We will test the hypothesis that interstitial fibroblasts drive prostate development and BPH using a combination of human tissue studies, explant imaging of rat prostate development and novel mouse models. Successful completion of our aims will establish a molecular etiology of glandular nodule formation in humans and new mouse models of BPH.

PI_NAMEs: STRAND, DOUGLAS WILLIAM (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: 3-Dimensional;5 Alpha-Reductase Inhibitor;Adult;Anatomy;Area;autocrine;Basic Science;Benign Prostatic Hypertrophy;Binding;Biological Assay;capsule;cell type;Chad;Characteristics;Clinical Trials;Data;Development;Disease;Embryo;Epithelial-Stromal Communication;Epithelium;Etiology;Fibroblasts;Genetic Recombination;Genitourinary system;Growth;Health;Human;human tissue;Hyperplasia;IGF1 gene;Image;in vivo;in vivo evaluation;Individual;inhibitor;Injections;innovation;interstitial;Kidney;Laboratories;Ligands;Medical;Medical center;Mesenchyme;midkine;Mitogens;Modeling;Molecular;Morphogenesis;morphogens;mouse model;Mus;Nodule;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Organ Culture Techniques;Organogenesis;Organoids;overexpression;paracrine;Paracrine Communication;pleiotrophin;Population;postnatal;Prevention;Proliferating;Prostate;Prostatic Urethra;public health relevance;Rattus;receptor;Receptor Activation;Receptor Inhibition;Regulation;response;Role;Signal Induction;Signal Transduction;Stromal Cells;Subcellular Anatomy;Testing;transcriptomics;Translational Research;Xenograft procedure

PROJECT_TITLE: Interstitial fibroblasts drive prostate branching morphogenesis

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

PHR: Project Title: Evaluation of Antibody Responses Elicited by Zika Vaccination in Flavivirus-naïve and - experienced Individuals PROJECT NARRATIVE: Vaccination is a fundamental tool used to protect individuals from infectious diseases. This research will provide a thorough understanding of antibody responses to Zika vaccination in individuals who live in flavivirus- endemic and non-endemic regions, and translate into viable vaccine strategies to protect individuals living in or traveling to endemic areas where Zika virus and potentially other flavivirus infections, such as dengue, co- circulate.

PI_NAMEs: KREBS, SHELLY J (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Adenovirus Vector;Adenoviruses;Affinity;Animal Model;Antibodies;Antibody Repertoire;Antibody Response;Antibody-Dependent Enhancement;Antigens;Area;B cell repertoire;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Biological Assay;Cell Lineage;Cells;Communicable Diseases;comparative;cross reactivity;Data;Defect;Dengue;Dengue Infection;Dengue Virus;design;Development;Disease;Dose;Epidemiology;Epitopes;Evaluation;Evolution;experience;Exposure to;Flavivirus;Flavivirus Infections;Flow Cytometry;Genes;Goals;Human;Humoral Immunities;Immunity;Immunization;Immunodominant Epitopes;Immunoglobulin Somatic Hypermutation;In Vitro;Inactivated Vaccines;Individual;Infection;insight;Japanese encephalitis virus;Lateral;Length;Longevity;Maps;member;Memory B-Lymphocyte;memory recall;Methodology;Methods;Monoclonal Antibodies;mouse model;Mus;Neurologic;neurological pathology;neutralizing antibody;next generation sequencing;permissiveness;Phase;Plasma;Population;Prevalence;Publishing;Puerto Rico;Reporting;Research;Research Personnel;response;Role;Sampling;Serotyping;Shapes;single cell sequencing;single-cell RNA sequencing;Sorting;Specificity;Technology;Tissues;tool;transcriptome sequencing;Translating;Travel;Vaccinated;Vaccination;vaccination strategy;vaccine candidate;Vaccine Clinical Trial;vaccine development;vaccine response;vaccine strategy;Vaccinee;Vaccines;vector;Virus;Virus Replication;Yellow fever virus;ZIKA;Zika Virus;Zika virus vaccine

PROJECT_TITLE: Evaluation of Antibody Responses Elicited by Zika Vaccination in Flavivirus-naïve and -experienced Individuals

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ORG_DEPT: BIOCHEMISTRY

PHR: Narrative: Intrinsically disordered proteins are a recently recognized class of proteins that do not fit classical structure/function paradigms, but participate in fundamental physiological processes. The prevalence and role of such proteins in mediating and regulating critical membrane trafficking and organization pathways required for cell function and survival is only now becoming appreciated. This project aims to clarify mechanisms that link the structural and dynamical properties of disordered proteins to their ability to orchestrate membrane fusion reactions and to organize intracellular membranous compartments.

PI_NAMEs: ELIEZER, DAVID  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: AGFG1 gene;Area;Awareness;Binding;Binding Proteins;Biological Assay;Biological Models;Biological Process;Cell Physiology;Cell Survival;cell type;Cellular Membrane;Disease;Exocytosis;Goals;In Situ;In Vitro;in vivo;Inosine Diphosphate;Link;Mediating;Membrane;Membrane Fusion;Modeling;Nature;Neurons;Organelles;Pathway interactions;Physical condensation;Physiological;Physiological Processes;Prevalence;Property;protein function;Protein Region;Proteins;Reaction;recruit;Recycling;Regulation;Research;Role;Specificity;Structure;Synapsins;synuclein;System;trafficking;Vesicle

PROJECT_TITLE: Structure and Function of Protein Disorder in Membrane Trafficking and Organization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Neurons are continuously born in the hippocampal neurogenic niche in the brain, and how they mature and integrate into existing circuits can have a large impact on hippocampal dependent behaviors and learning and memory. We have found that kainate receptors (a family of glutamate receptors) regulate the maturation of newborn neurons, which could account for their roles in affective behaviors and memory processes. Understanding these mechanisms will potentially provide insight into developing new therapies for age related memory disorders.

PI_NAMEs: CONTRACTOR, ANIS  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Ablation;Acceleration;Adult;adult neurogenesis;Affect;Affective;Age-Related Memory Disorders;Alzheimer's Disease;Animals;Array tomography;Behavior;behavior measurement;Brain;Cell Maturation;Cells;Chlorides;conditional knockout;dentate gyrus;Developmental Process;Episodic memory;Equilibrium;experimental study;Family;gamma-Aminobutyric Acid;Genes;Genetic Recombination;Glutamate Receptor;Goals;granule cell;Head;Hippocampus;Image;Impairment;in vivo;insight;Interneurons;Kainic Acid Receptors;Learning;Link;Maps;Memory;memory process;microendoscope;Microscope;Modeling;Molecular;Molecular Profiling;Mood Disorders;Mus;nerve stem cell;Nervous System Disorder;neural circuit;neural correlate;Neurodegenerative Disorders;Neurons;neuropsychiatric disorder;newborn neuron;normal aging;novel;novel therapeutics;optogenetics;Pattern;Phase;Play;Post-Traumatic Stress Disorders;Process;Property;Receptor Signaling;Resolution;Retrieval;Role;Schizophrenia;Signal Pathway;Signal Transduction;single cell analysis;Space Perception;spatiotemporal;symporter;Synapses;Synaptic plasticity;Testing;tool;transcriptome;transmission process

PROJECT_TITLE: Glutamate receptor signaling pathways in the circuit integration of adult-born neurons

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR-M]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE To address the urgent need for new therapies for glioma, the most common type of brain tumor, we tested hundreds of chemicals and discovered that drugs targeting a specific metabolic pathway preferentially kill brain tumor cells with a mutation in a gene called IDH1, which is a very common genetic alteration in this disease. In this proposal, we seek to understand why cells with IDH1 mutations die in response to inhibition of this metabolic pathway and to determine whether a newly developed drug that targets this metabolic pathway shows activity in preclinical models of glioma. Successful achievement of these research goals will lay the preclinical foundation necessary to advance this treatment strategy toward a clinical trial for brain tumor patients.

PI_NAMEs: ABDULLAH, KALIL G;MCBRAYER, SAMUEL KENT (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Achievement;Address;Adult Glioma;Anabolism;Apoptosis;Biological;Biological Markers;Brain;Brain Neoplasms;Branched-Chain Amino Acids;cancer therapy;Catabolism;Cell Death;Cell Survival;Cells;Central Nervous System Neoplasms;Chemicals;Chromatin Structure;Clinic;Clinical;clinical translation;Clinical Trials;combat;Coupled;Defect;Dependence;design;Dihydroorotate dehydrogenase;Dihydroorotate Dehydrogenase Inhibitor;Disease;disease model;DNA biosynthesis;Drug Targeting;efficacy evaluation;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzyme Inhibitor Drugs;Enzymes;experimental study;FDA approved;Foundations;Functional disorder;Future;gain of function;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Heterogeneity;Glioblastoma;Glioma;glioma cell line;Glutaminase;Glutamine;Goals;Homeostasis;Human;Impairment;in vivo;Individual;inhibitor;inhibitor therapy;Isocitrate Dehydrogenase;Lipids;Malignant - descriptor;Malignant Neoplasms;Medical;Metabolic;Metabolic Pathway;Metabolism;Modeling;Molecular;mouse model;mutant;Mutate;Mutation;neoplastic cell;Newly Diagnosed;novel;novel therapeutic intervention;novel therapeutics;nucleotide metabolism;Oncoproteins;Organoids;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phospholipids;pre-clinical;Pre-Clinical Model;preclinical trial;predicting response;predictive marker;Predisposition;Primary Brain Neoplasms;Production;Protein Glycosylation;Proteins;Pyrimidine;Pyrimidine Nucleotides;Pyrimidine Synthesis Inhibition;Radiation therapy;Research;research clinical testing;Resistance;response;RNA chemical synthesis;Role;standard care;Stress;success;Surveys;Survival Rate;System;Testing;Therapeutic;Tissues;Translating;treatment response;treatment strategy;tumor;Tumor Cell Line;tumor growth;tumor microenvironment;United States;Work

PROJECT_TITLE: Exploiting Pyrimidine Nucleotide Synthesis Dependence for IDH Mutant Glioma Therapy

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Due to a low but present risk of potentially life-threatening blood infection or bacterial meningitis, and a lack of evidence-based tools to help guide clinicians in their management, thousands of young infants 61 to 90 days old with fever undergo lumbar punctures and are hospitalized each year, with substantial differences in testing and hospitalization depending on the emergency department where the infant receives care. Because of this variability in care and the many unnecessary lumbar punctures and hospitalizations of these infants, there is a pressing need to derive a clinical prediction rule that can guide the management of infants 61 to 90 days old evaluated for fever in the emergency department. The objective of this project is to develop a clinical prediction rule that will allow clinicians to identify infants 61 to 90 days old with fever at low versus non-negligible risk of blood infection and bacterial meningitis.

PI_NAMEs: ARONSON, PAUL L (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Academy;Accident and Emergency department;Address;age group;American;Antibiotics;Applied Research;Bacteremia;Bacterial Infections;Bacterial Meningitis;Biological Markers;Blood;Blood Tests;Caring;Cerebrospinal Fluid;Characteristics;Clinical;clinical examination;Clinical Practice Guideline;clinical predictive model;clinical predictors;cohort;Data;Derivation procedure;Emergency Care;ethnic health disparity;Evaluation;evidence base;febrile infant;Fever;Future;Goals;Health system;high risk;Hospitalization;Hospitals;improved;Individual;Infant;Inflammatory;Laboratories;Life;Natural Language Processing;novel;pediatric emergency;Pediatrics;Performance;Positioning Attribute;Prevalence;Principal Investigator;procalcitonin;Procedures;Prospective Studies;Publishing;racial health disparity;Registries;Research;Resources;Risk;risk stratification;Sepsis;Severity of illness;Specificity;Spinal Puncture;Testing;tool;Unnecessary Procedures;Urine;Validation;validation studies;Variant;Visit

PROJECT_TITLE: Derivation and validation of a clinical prediction rule to identify febrile infants 61 to 90 days old at low and non-negligible risk of invasive bacterial infections

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CAMBRIDGE

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

ORG_STATE: MA

PHR: Project Narrative The failure to form proper physical connections with chromosomes during mitosis can result in errors in chromosome numbers or cause chromosome rearrangements. In both cases, these defects are thought to contribute to tumor progression and birth defects. Understanding the means by which these units of DNA, and the genetic information that they contain, are properly distributed to new cells is critical for the diagnosis and treatment of disease. This proposed work will analyze the mechanisms by which a key cell division structure (termed the kinetochore) associates with both DNA and the rod-like microtubule polymers from the mitotic spindle that provides the structure and force to segregate the chromosomes.

PI_NAMEs: CHEESEMAN, IAIN MCPHERSON (contact)

PROJECT_TERMS: Affinity Chromatography;Biochemical;Biological;Cell Cycle Arrest;Cell division;Cell Physiology;Cells;Chromosome Segregation;Chromosomes;Congenital Abnormality;Defect;defined contribution;Diagnosis;Disease;DNA;Failure;Genes;genetic approach;genetic information;Goals;Human;Individual;Interphase Cell;Kinetochores;Laboratories;macromolecular assembly;Meiosis;Microtubule Polymerization;Microtubules;Mitosis;Mitotic spindle;Modification;Molecular;Molecular Analysis;molecular modeling;Optics;Phenotype;Physiological;Proteins;Proteomics;reconstitution;Rod;screening;senescence;Site;Structure;tumor progression;Work

PROJECT_TITLE: Molecular Analysis of Kinetochore Function

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The underlying gene regulatory networks and genome architecture of muscle stem (satellite) cells are largely unexplored. In this proposal, we will explore epigenome regulatory mechanisms that establish myogenic precursor identity, setting the stage for myogenic differentiation. Our findings will shed important light on the satellite cell epigenome and its three dimensional architecture, provide a deeper understanding of the ability of these cells to regenerate, and provide insights into new avenues for treatment of age-and disease-associated muscle wasting.

PI_NAMEs: DYNLACHT, BRIAN D (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: 3-Dimensional;Ablation;Age;Aging;Architecture;Binding;Binding Sites;Biochemical;candidate selection;Cells;Chimeric Proteins;Chromatin;Chromatin Loop;Chromatin Modeling;chromatin remodeling;chromosome conformation capture;Classification;Code;Collaborations;Complex;Data;Disease;Distal;Elements;embryonic stem cell;Engraftment;Enhancers;Environment;epigenetic memory;Epigenetic Process;epigenome;Exercise;Exhibits;experimental study;Gene Expression;gene regulatory network;Genes;Genome;genome-wide analysis;Genomics;Goals;human embryonic stem cell;In Vitro;in vivo;insight;interest;Learning;Modeling;Molecular;Mus;Muscle;Muscle Cells;muscle progenitor cell;Muscle satellite cell;Muscular Atrophy;mutant;Mutation;Myoblasts;Myomatous neoplasm;Natural regeneration;novel;Pathologic;Play;Population;Process;progenitor;promoter;Property;protein purification;Proteins;Proteomics;recruit;Regenerative Medicine;Regulatory Element;repaired;Resolution;Rhabdomyosarcoma;Role;Scheme;self-renewal;Shapes;Site;Specific qualifier value;stem;stem cell fate specification;stem cell function;stem cell niche;stem cell population;stem cells;Structure;System;transcription factor;Transplantation;wasting

PROJECT_TITLE: Exploring networks underlying muscle stem cell identity - Resubmission - 1

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Understanding the sexual phenotype –or gender -has far reaching implications for human health and well-being. Trainee research on steroid hormones, maternal stress, changing environments, maternal and infant health, and healthy sexual behavior and reproduction, using human, non- human model systems, and evolutionarily diverse non-model systems will lead to insights into the basic mechanisms of reproduction and development and to understanding of the physiological differences between the sexes and their influence on illness and health outcomes, all of which will be valuable to policy makers, medical research, and health care.

PI_NAMEs: SENGELAUB, DALE R (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: reproductive

PROJECT_TITLE: Common Themes in Reproductive Diversity


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: LOS ANGELES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative: This training grant aims to continue to develop research scientists that are well versed in physics, biology, mathematics, chemistry, engineering and computer science, and who also understand the application of these disciplines to the instruments and techniques used in the diagnosis, monitoring and treatment of disease as well as research fields that help us understand basic mechanisms of disease. These scientists will become actively involved in research into new methods that seek earlier diagnosis of disease as well as more specific (patient specific, disease specific) treatments of disease in many clinical applications.

PI_NAMEs: MCNITT-GRAY, MICHAEL F (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TITLE: Physics and Biology in Medicine Research Training


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Rehabilitation;Rural Health;Social Determinants of Health

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The proposed study is relevant to public health in that it addresses a rapidly growing group of patients with cancer, older adults (≥70 years), with the goal of delivering psychotherapy (i.e., the CARE intervention) to older adults with limited access to mental health services. Research indicates that older adults with medical illnesses and depression have difficulty adhering to aftercare, are not typically connected to mental health services, and are at high risk for completing suicide, yet they continue to be overlooked in routine clinical encounters; these risks are elevated among individuals living in rural areas. Thus, this study is aligned with the NCI’s goals of improving the reach and quality of cancer care for older adults, with an emphasis on rural populations.

PI_NAMEs: NELSON, CHRISTIAN J (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Achievement;Address;Aftercare;Age;age related;Aging;Anxiety;Area;arm;cancer care;cancer diagnosis;Cancer Patient;Cancer Survivor;Caring;Cessation of life;Clergy;Clinical;clinical encounter;cognitive reappraisal;Communities;community organizations;completed suicide;coping;cost effective;Counseling;Data;Decision Making;depressive symptoms;design;Development;Developmental Process;Distress;efficacy testing;Elderly;Feedback;Funding Opportunities;General Population;Geography;Goals;high risk;Hospitals;improved;Individual;Information Technology;Intervention;Loneliness;Malignant Neoplasms;Manuals;Mediating;Mediation;Medical;Mental Depression;Mental disorders;Mental Health Services;metropolitan;mortality;multidisciplinary;novel;Nurses;older adult;Oncology;Outcome;Participant;Patients;peer;Population;post intervention;primary outcome;Psychiatry;Psychologist;Psychotherapy;Public Health;Randomized;recruit;Reporting;Research;Risk;Rural;rural area;Rural Population;rural residence;rural setting;screening;secondary outcome;service utilization;Services;Social isolation;Social Work;Social Workers;Telephone;telephone delivery;telephone session;Testing;theories;therapy design;Travel;treatment adherence;Treatment Protocols;Underserved Population;urban dwelling;willingness;young adult

PROJECT_TITLE: Cancer and Aging Reflections for Elders (CARE): A Geriatric-Specific Psychotherapy for Older Adults with Cancer

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: BERKELEY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Our work explores the ways in which diverse bacteria create cellular compartments to store iron and produce highly ordered magnetic nanoparticles. These particles have many potential biomedical applications including their potential use as MRI contrast agents, as vehicles for targeted delivery of drugs and as a medium to kill tumors using heat. By understanding the molecular details of these naturally occurring processes, we hope to identify new drug targets for combatting bacterial pathogens and to facilitate a more rational design of next generation biomedical applications.

PI_NAMEs: KOMEILI, ARASH  (contact)

PROJECT_TERMS: Actins;Area;Bacteria;Biochemical;Biochemical Reaction;Biogenesis;Biologic Characteristic;Biological;Biological Assay;Biological Models;Biology;biomineralization;Cell membrane;Cell Physiology;Cells;Chemicals;Contrast Media;Cytoskeleton;delivery vehicle;Development;Drug Delivery Systems;Engineering;Environment;Evolution;Genes;Genetic;gut microbiome;Health;Hyperthermia;Individual;interest;Iron;Knowledge;Lipid Bilayers;Lipid Binding;Magnetic nanoparticles;Magnetic Resonance Imaging;Magnetism;magnetosomes;member;membrane biogenesis;Microbe;Molecular;Names;nanoscale;neoplastic cell;new therapeutic target;next generation;novel;opportunistic pathogen;Organelles;Organism;Output;Oxygen;particle;pathogenic bacteria;Pathway interactions;physical property;Physiological;Prevalence;Process;programs;Protein Sortings;Proteins;rational design;Research;targeted delivery;tumor;Work

PROJECT_TITLE: Molecular Mechanisms of Organelle Formation in Bacteria

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: ATHENS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Treatment advances in psychosis may be limited by the use of phenomenology-defined diagnoses based on symptomatic outcomes, rather than by neurobiological constructs monitored by quantitative characteristics. The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) uses biomarkers to define psychosis subgroups with the goal of testing the advantages of B-SNIP biomarkers for diagnostic and therapeutic decisions, consistent with principles in the NIMH Strategic Plan. We propose to test Biotype1 psychosis subgroup with clozapine, and predict a differential clinical response to clozapine compared with Biotype2, marked by normalization of IEA, cortical attractor network activity and an advantage over usual antipsychotic drugs, establishing low IEA in Biotype1 as a predictive biomarker for clozapine efficacy.

PI_NAMEs: CLEMENTZ, BRETT A (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: anti-depressive agents;Antipsychotic Agents;Bacterial Artificial Chromosomes;Biological Markers;biotypes;blind;Blinded;Blood;Characteristics;Chemistry;Clinical;Clinical assessments;clinical efficacy;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Design;Clozapine;Cognition;Communities;Complex;Consent;deviant;Diagnosis;Diagnostic;Dose;Double-Blind Method;Dropout;Drug Monitoring;Electrocardiogram;Electroencephalography;forging;Future;Goals;Grant;improved;Individual;Libraries;Measures;Monitor;Myocarditis;National Institute of Mental Health;neural;Neurobiology;Neutropenia;Outcome;Participant;Patients;Pharmaceutical Preparations;Pharmacotherapy;phenomenological models;Phenotype;phenotypic biomarker;Physicians;Physiological;Plasma;predictive marker;Preparation;proband;Prognosis;Psychoses;Randomized;recruit;Regimen;research clinical testing;Resistance;response;Risperidone;Saccades;Safety;Sampling;Schedule;Schizophrenia;Seizures;side effect;Site;Specific qualifier value;stimulus processing;Strategic Planning;Subgroup;symptomatic improvement;Symptoms;Testing;Therapeutic;Time;Titrations;treatment duration;volunteer;Work

PROJECT_TITLE: 5/5: Selective Antipsychotic Response to Clozapine in B-SNIP Biotype-1 (CLOZAPINE)


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE Delirium is a devasting acute confusional state that is common in older adults after surgery or in the hospital, especially with Alzheimer's disease. This project investigates the molecular mechanisms that link inflammation to impaired metabolism in delirium and Alzheimer's disease, and how small molecule metabolites with roles in aging might lead to metabolic therapies for delirium.

PI_NAMEs: NEWMAN, JOHN C (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acute;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;analog;APP-PS1;Area;Attention;Basic Science;Behavior;Behavioral;beta-Hydroxybutyrate;Biological Markers;Biology;Biology of Aging;Brain;Cells;Cerebrospinal Fluid;Cerebrum;Chronic;Clinical;clinical development;Clinical Research;Cognitive deficits;cohort;Cohort Studies;Compensation;Confusion;Conscious;Consumption;Cultured Cells;Data;Delirium;Dementia;Development;disability;drug discovery;Elderly;Encephalitis;Energy Metabolism;Energy-Generating Resources;Enzyme Induction;Enzymes;Failure;Fasting;Functional disorder;Genetic Models;Geroscience;glial activation;Glucose;glucose metabolism;Goals;high risk;Hospitalization;Hospitals;Human;Hypoxia;Impairment;improved;In Vitro;in vitro Model;in vivo;Induced Neurons;Infection;Inflammasome;Inflammation;Inflammatory;Injections;innovation;Intervention;ketogenic diet;Ketone Bodies;Ketones;Knock-out;Knockout Mice;Link;Lipopolysaccharides;Macrophage;Macrophage Activation;Mediator;Memory;Metabolic;Metabolic dysfunction;Metabolism;Microglia;Modeling;Molecular;mortality risk;mouse model;Mus;NAD+ Nucleosidase;neuroinflammation;Neuronal Dysfunction;Neurons;Nicotinamide adenine dinucleotide;older adult;Operative Surgical Procedures;Oxidative Stress;Pathway interactions;Patients;Peripheral;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Phenotype;physiologic stressor;postoperative delirium;Postoperative Period;Predisposition;prevent;Prevention;resilience;Risk;Role;Sampling;sedative;Signal Transduction;small molecule;Surgical complication;Syndrome;System;Testing;theories;Work

PROJECT_TITLE: Geroscience metabolites beta-hydroxybutyrate and NAD+ linking inflammation and neuroenergetic failure in delirium


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MALVERN

ORG_NAME: VENATORX PHARMACEUTICALS, INC.

PHR: PROJECT NARRATIVE The penicillin binding protein-targeting β-lactams have been a mainstay therapeutic option for infections caused by enteric gram negative bacteria for more than 50 years. Efficacy of these agents is threatened by the continued expansion of β-lactamases (e.g., NDM) that contribute to carbapenem resistance in Enterobacterales including subtypes that are refractory to clinically available β-lactams or β-lactam/β-lactamase inhibitor combinations. This application focuses on the development of a cyclic boronate PBP inhibitor that circumvents class-specific resistance to β-lactams, resets the resistance clock and offers a new intravenous therapeutic option for the treatment of infections caused by carbapenem-resistant Enterobacterales (CRE).

PI_NAMEs: BOYD, STEVEN ARMEN (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;analytical method;antagonist;Anti-Bacterial Agents;Antibiotics;appropriate dose;bactericide;beta-Lactam Resistance;beta-Lactamase;beta-Lactams;Binding;Binding Proteins;Biological;Canada;carbapenem resistance;carbapenem resistant Enterobacterales;Carbapenems;Ceftazidime;Centers for Disease Control and Prevention (U.S.);Classification;Clinical;Clinical Research;Contracts;Cyclic GMP;design;Development;Dose;Drug Kinetics;drug metabolism;Drug resistance;Enteral;Escherichia coli;Escherichia coli Infections;Evaluation;Evolution;Exhibits;Formulation;Frequencies;Future;genotoxicity;global health;Gram-Negative Bacteria;Health care facility;Hospitals;Imipenem;improved;In Vitro;in vivo;Infection;inhibitor;innovation;Innovative Therapy;Intravenous;Kinetics;Lactams;Lead;lead optimization;lead series;manufacture;manufacturing organization;Maximum Tolerated Dose;Medical;Meropenem;method development;Methods;Microbiology;Modeling;Mus;Mutation;novel;novel antibiotic class;pathogen;Patients;Penicillin-Binding Proteins;Peptidyltransferase;Periodicity;Pharmaceutical Preparations;pharmacokinetic model;pharmacokinetics and pharmacodynamics;Pharmacology;Plants;pre-clinical;pre-Investigational New Drug meeting;preclinical development;preclinical study;Preparation;Process;programs;Property;Qualifying;Rattus;Refractory;Research Design;Resistance;Resistance development;resistance frequency;resistance mechanism;Rodent;Safety;safety assessment;Series;Serine;Structure;Study models;synergism;targeted agent;Technology Transfer;Therapeutic;Thigh structure;Time;Toxicology;Validation;World Health Organization

PROJECT_TITLE: Novel cyclic boronate Penicillin Binding Protein Inhibitors to eliminate the threat posed by β-lactamases and enable a future treatment option for carbapenem-resistant Enterobacterales infections


ORG_DEPT: PSYCHIATRY

PHR: Project Narrative Treatment advances in psychosis are limited by the use of phenomenology-defined diagnoses based on symptomatic outcomes, rather than by neurobiological constructs monitored by quantitative characteristics. The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) uses biomarkers to define psychosis subgroups with the goal of testing the advantages of B-SNIP biomarkers for diagnostic and therapeutic decisions, consistent with principles in the NIMH Strategic Plan. We propose to test Biotype1 psychosis subgroup with clozapine, and predict a differential clinical response to clozapine compared with Biotype2, marked by normalization of IEA, cortical attractor network activity and an advantage over usual antipsychotic drugs, establishing low IEA in Biotype1 as a predictive biomarker for clozapine efficacy.

PI_NAMEs: PEARLSON, GODFREY D (contact)

PROJECT_TITLE: 3/5 Selective Antipsychotic Response to Clozapine in B-SNIP Biotype-1 (CLOZAPINE)


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DETROIT

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Narrative Retinal neurons exhibit either excitation or inhibition to light inputs. In the dim light ambient conditions, two kinds of photoreceptors may interrupt each other, inducing mixed excitatory and inhibitory responses in the downstream neurons. We will investigate the cellular light responses and the mechanisms because both rod and cone dysfunction cause reduced vision in the mesopic vision.

PI_NAMEs: ICHINOSE, TOMOMI  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Affect;Amacrine Cells;Biological;Calcium;cell type;Cells;Code;Darkness;Detection;Excitatory Postsynaptic Potentials;Exhibits;Functional disorder;ganglion cell;Goals;horizontal cell;Image;Inner Plexiform Layer;Interneurons;Interruption;Light;Light Adaptations;Mediating;Molecular;Morphology;Motion;Mus;Neurons;Outcome;Output;patch clamp;Pathway interactions;pharmacologic;Photoreceptors;Physiological;Play;Preparation;response;Retina;retinal neuron;Role;Shapes;Signal Pathway;signal processing;Signal Transduction;starburst amacrine cell;Stimulus;System;Technology;Testing;Tissues;tool;Vertebrate Photoreceptors;Vision;Visual;Visual impairment;Whole-Cell Recordings

PROJECT_TITLE: ON and OFF visual signaling in the retinal interneurons

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: In this proposal, we will perform a comprehensive study to identify the germline genetic variations that predispose individuals to development of MGUS and those that contribute to increased risk of progression to MM among those that have MGUS. We also will examine how these genetic findings differ based on race and how they compare to existing clinical factors, in order to develop a targeted screening approach that in the long run will allow earlier intervention and eventual prevention of active MM.

PI_NAMEs: BROWN, ELIZABETH E;KUMAR, SHAJI KUNNATHU;VACHON, CELINE M (contact)

PROGRAM_OFFICER_NAME: CAGA-ANAN, EMILIE CHARLISSE F

PROJECT_TERMS: African American;African American population;Age;American;ARID1A gene;Benign;biobank;Bone Marrow;Case/Control Studies;Categories;CDKN2A gene;Clinical;Clinical Research;clinical risk;cohort;cost effective;Detection;Development;Disease;Early Intervention;Environmental Exposure;Epidemiology;Etiology;European;Evaluation;exome sequencing;Family;Family Study;First Degree Relative;follow-up;Fracture;Frequencies;Gene Expression;Genes;Genetic;genetic epidemiology;Genetic Predisposition to Disease;genetic risk factor;Genetic study;genetic variant;Genetic Variation;genome wide association study;genomic data;Genomics;Genotype;Germ Lines;Heritability;Heterogeneity;high risk;human old age (65+);Immunoglobulin A;Immunoglobulin G;Immunoglobulin Isotypes;Immunoglobulin M;Impairment;improved;Individual;infection risk;insight;KDM1A gene;Kidney;Light;Lymphoid Cell;Meta-Analysis;Modeling;Monitor;Monoclonal gammopathy of uncertain significance;Morbidity - disease rate;mortality;multi-ethnic;Multiple Myeloma;Nested Case-Control Study;novel;Obesity;Osteoporosis;Outcome;Patients;Peripheral Blood Mononuclear Cell;Persons;Plasma Cells;polygenic risk score;Population;Predisposition;Prevention;progression risk;Proteins;Race;rare variant;Recording of previous events;Risk;Risk Factors;screening;Sorting;Subgroup;Susceptibility Gene;Thrombosis;Time;Tissues;transcriptome;transcriptome sequencing;Validation;Variant;Whole Blood;Work

PROJECT_TITLE: Impact of Genetic susceptibility along the continuum from MGUS to MM

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative We propose to develop a comprehensive set of computational methods for advanced analytics in genome-wide association studies. These new methods will facilitate integrative analysis of genome-wide association studies with gene expression mapping studies, investigation of causal relationship among complex traits, and genetic prediction of phenotypes with polygenic risk scores. These methods are essential for understanding the transcriptomic and causal mechanism underlying common diseases, enabling accurate and robust genetic prediction of disease risks, and facilitating biological discoveries.

PI_NAMEs: ZHOU, XIANG  (contact)

PROGRAM_OFFICER_NAME: ZHANG, LI

PROJECT_TERMS: advanced analytics;Advanced Development;African American population;Algorithms;American;Architecture;biobank;Biological;Biology;Calibration;Clinical;clinical application;clinical translation;Communities;Complex;computational suite;Computer software;computerized tools;Computing Methodologies;Data;data complexity;Dependence;Development;Disease;disease diagnosis;disorder risk;Etiology;European;experience;flexibility;Foundations;Funding;Gene Expression;Gene Frequency;Genes;Genetic;genetic architecture;genetic association;genetic predictors;Genetic study;genetic variant;genome wide association study;genome-wide analysis;Genomics;Goals;Health;Heritability;Human;improved;Individual;insight;instrument;interest;Investigation;Joints;Knowledge;Linkage Disequilibrium;Maps;Mendelian randomization;method development;Methodology;Methods;Minor;Modeling;Molecular;novel;novel diagnostics;novel therapeutics;open source;Phenotype;pleiotropism;polygenic risk score;precision medicine;predictive tools;Research;Risk Factors;Sampling;Scoring Method;screening;Signal Transduction;simulation;Software Tools;Solid;statistics;success;tool;trait;transcriptome;transcriptomics;Uncertainty;user-friendly;Variant

PROJECT_TITLE: New Computational Tools for Advanced Analytics in Genome-wide Association Studies

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Our work is based on the profound need to increase our understanding of metastasis, the primary cause of breast cancer deaths, so that we can develop and test the next generation of therapeutics to end this disease. We are developing a novel platform that will, for the first time, allow us to identify the mechanisms regulating metastatic dormancy and recurrence in native microenvironments and rapidly for screen therapeutics that prevent recurrence.

PI_NAMEs: PROVENZANO, PAOLO ;WOOD, DAVID KEVIN (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Aftercare;Apoptosis;Behavior;Biomedical Engineering;Blocking Antibodies;Body System;Bone Marrow;Breast Cancer Patient;Breast Carcinoma;Cancer Biology;cancer cell;cancer stem cell;Cell Line;Cell Separation;Cell Survival;Cells;cellular engineering;Cessation of life;Coculture Techniques;combinatorial;Complex;CRISPR screen;CRISPR/Cas technology;Cues;cytokine;Development;Disease;Disease Progression;Disease Resistance;Engineering;Environment;Environmental Risk Factor;Epigenetic Process;Event;experimental study;Extracellular Matrix;Flow Cytometry;Focal Adhesions;Generations;Genetic;Genetic study;genome-wide;Heterogeneity;high throughput screening;Human;human cancer mouse model;human model;improved;In Vitro;in vivo;innovative technologies;Integrins;Intrinsic factor;Lung;Macrophage;Malignant Breast Neoplasm;Malignant Epithelial Cell;Malignant Neoplasms;Measures;Microfluidics;Micrometastasis;Molecular;mouse model;multi-photon;Mus;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;optical imaging;Organ;Outcome;Paracrine Communication;Pathway interactions;Patients;Peptide Initiation Factors;Population;prevent;Probability;programs;Proliferating;Property;Rapid screening;receptor;Recurrence;Signal Pathway;Signal Transduction;Site;Sorting;Technology;Testing;Therapeutic;therapeutic target;therapy resistant;Time;Tissues;transcriptome;tumor;Work

PROJECT_TITLE: A platform to functionally sort and analyze tumor cells within combinatorial metastatic micorenvironments

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE As of 2015, 30 million Americans (9.4% of the US population) had diabetes and it was the seventh leading cause of death based on 79,535 death certificates. Despite a $327 billion investment in diabetes care in 2017, 31% of those with diabetes have a hemoglobin A1c >9%, well above goal and greatly increasing the risk for diabetes related complications. Recent innovations in diabetes technology may finally allow implanted, fully autonomous, insulin delivery; the purpose of the present study is to evaluate the features of intraperitoneal insulin and its potential for future use in a full closed-loop implanted insulin delivery system.

PI_NAMEs: LAL, RAYHAN  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Acute;Adult;age group;Algorithms;American;blood glucose regulation;Blood Vessels;Body Composition;Body fat;Body mass index;bone health;Cardiovascular Diseases;cardiovascular risk factor;Caring;Catheters;Cause of Death;Childhood;Clinic;Clinical;Clinical Research;Clinical Trials;cohort;Collaborations;Complications of Diabetes Mellitus;computer scientist;Continuous Glucose Monitor;Coronary Arteriosclerosis;Data;Death Certificates;design;Development;Devices;Diabetes Mellitus;diabetes risk;Drug Kinetics;Electrical Engineering;Endocrinology;Epidemiology;Ethics;Exercise;experience;Faculty;FDA approved;Fellowship;Formulation;Future;Glucagon;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;Health Technology;Healthcare;Human;Hybrids;Hyperglycemia;Hypoglycemia;Implant;improved;in silico;Individual;innovation;instructor;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;interest;Intervention;intraperitoneal;Intravenous;Investigation;Investments;Kidney Diseases;Kinetics;Letters;Location;Manufacturer;Mentors;Mentorship;Modeling;Morbidity - disease rate;Neuropathy;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Pathway interactions;Patients;performance tests;Peritoneal;Peritoneum;Persons;Physiological;Population;Positioning Attribute;Prevention;Publishing;Pump;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Design;Research Personnel;Research Training;response;Retinal Diseases;Route;Running;Safety;satisfaction;socioeconomics;Speed;statistics;Structure;subcutaneous;System;Tail;Technology;Testing;Therapeutic;Time;Trust;United States;Universities;Visceral;Work

PROJECT_TITLE: The Optimal Pathway to Implanted Autonomous Insulin Delivery

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative This study will inform the development of behavioral and biological approaches for novel interventions aimed at preventing and reducing health disparities in women. It will also extend understanding of the environment's effect on the impact of DNAm age acceleration of chronic disease disparities.

PI_NAMEs: NUGENT, NICOLE R;PETERS, EDWARD S (contact);RUNG, ARIANE L;SMITH, ALICIA K

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;adverse outcome;Age;age acceleration;age related;age-related disease;Aging;Behavior;Behavioral;Biological;Biological Aging;Biological Process;Black race;Blood specimen;Cardiovascular Diseases;Caring;Cell Aging;Characteristics;Chronic;Chronic Disease;cohort;Collection;Communities;Complex;Data;Data Collection;Deceleration;Development;Diabetes Mellitus;Disasters;Disease;disease disparity;Disparate;disparities in women;Disparity;Disparity population;DNA Methylation;drinking;economic disparity;Economics;Environment;Environmental Impact;environmental stressor;experience;Exposure to;Faith;Financial Hardship;Gene Expression;geographic disparity;Geography;Goals;Health;Health behavior;health data;health disparities in women;health disparity;health disparity populations;Healthy Eating;Hypertension;Income;indexing;Individual;Individual Differences;Informal Social Control;Intervention;Life Cycle Stages;Louisiana;Low Income Population;Malignant Neoplasms;Measurable;Measures;Mediating;Medical;Medical History;Mental Depression;Mental Health;Methods;Minority;Modification;Neighborhoods;novel;novel strategies;Obesity;Oils;Outcome;Outcome Study;Participant;Patient Self-Report;Physical activity;physical conditioning;Physical environment;Population;Post-Traumatic Stress Disorders;prevent;Process;promote resilience;psychologic;psychological symptom;Race;Recording of previous events;Reduce health disparities;Reporting;Research;resilience;resilience factor;resilience in aging;Resources;Respiratory Disease;Rural;Sampling;Smoking;social;Social Behavior;social capital;social disparities;Social Environment;social influence;social stressor;Stress;stressor;Telephone Interviews;Testing;therapy development;Time;Trauma;trauma exposure;traumatic stress;Woman

PROJECT_TITLE: The Impact of Environmental Stressors on Chronic Disease Disparities in Women


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: SEATTLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Post-translational modifications of histones and transcription factors are critical to gene function and misregulated in several diseases. We are developing chemical strategies to investigate the biophysical and biochemical effects of histone sumoylation and p53 methylation in human chromatin. Our studies will reveal new mechanisms underlying chromatin regulation and provide new therapeutic targets in diseases arising from its misregulation.

PI_NAMEs: CHATTERJEE, CHAMPAK  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Base Pairing;Biochemical;Biological;Biological Assay;Biophysics;Cells;cellular engineering;Chemicals;Chromatin;Chromatin Structure;Complex;Disease;Gene Expression Regulation;gene function;Genes;genetic information;Goals;Heterogeneity;Histone H2B;Histone H4;histone modification;Histones;Human;human disease;Methylation;Modification;Molecular;new therapeutic target;Nucleoproteins;Play;Post-Translational Protein Processing;Protein Family;Proteins;Regulation;Research Project Grants;Role;Site;Sumoylation Pathway;synthetic protein;Techniques;therapeutic target;tool;TP53 gene;transcription factor

PROJECT_TITLE: Chemical strategies to investigate biochemical crosstalk in human chromatin


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Mutations in the Crumbs homologue-1 (CRB1) gene lead to severe blinding disorders including retinitis pigmentosa and Leber congenital amaurosis. To date, there is no treatment for CRB1-mediated retinal diseases, and classical gene augmentation techniques are complicated by the expression of multiple CRB1 isoforms in cell-type-distinct localizations within the retina. This project will develop a CRB1 isoform-independent prime editing approach by establishing retinal organoid disease models and preclinical vectors in order to establish proof-of-concept for CRB1 prime editing therapeutics.

PI_NAMEs: QUINN, PETER MARTIN JOHN (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Adherens Junction;Adverse effects;Affect;base editing;Birth;Blindness;Cadaver;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;conditional knockout;Data;Dependovirus;Development;Disease;disease model;early childhood;Extracellular Domain;Family member;gene augmentation therapy;gene editing technology;Genes;Goals;Grant;Homologous Gene;Human;induced pluripotent stem cell;Inherited;innovation;insertion/deletion mutation;intein;Knockout Mice;Lead;Leber's amaurosis;Mediating;Modification;Molecular;Morphology;mouse model;Mus;mutant;Mutation;Neuroglia;novel;Organoids;Outcome Measure;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;phase I/IIa trial;Phenotype;Photoreceptors;postmitotic;pre-clinical;Prevalence;prime editing;prime editor;Protein Isoforms;Proteins;Rattus;Reporter;Research;Retina;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;Retinitis Pigmentosa;Role;Safety;Satellite Viruses;System;Techniques;Testing;therapeutic genome editing;therapy outcome;tool;transition mutation;transversion mutation;Treatment Efficacy;United States;vector;Viral;Visual Fields;Work

PROJECT_TITLE: Prime editing for Crumbs homologue 1 (CRB1) Inherited Retinal Dystrophies

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Narrative The Cincinnati T32 Training Program in Pediatric Clinical Pharmacology provides an outstanding resource for expanding and improving the current critically small pool of pediatric clinical pharmacologists by training the next generation of pediatric clinical investigators to assume leadership roles in developing innovative, high impact clinical and developmental pharmacology related approaches that will be transformative to how we use medicines in children. This will allow the implementation of personalized pediatric therapeutics and improve the quality of care and related health outcomes of children.

PI_NAMEs: GLAUSER, TRACY A;TANG GIRDWOOD, SONYA C (contact);TAYLOR, ZACHARY L

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TITLE: T32 Cincinnati Pediatric Clinical Pharmacology Training Program


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE Proteins at the cell surface can be transported into the cell and then returned to the cell surface. This process, known as endocytic recycling, regulates the function of many proteins. We are proposing studies to elucidate in mechanistic detail how endocytic recycling occurs. This understanding will also shed insights into disease mechanisms, as endocytic recycling plays many important physiologic roles.

PI_NAMEs: HSU, VICTOR W (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Affect;Ankyrin Repeat;Capsid Proteins;cell motility;Cell Polarity;Cell surface;Cells;Clathrin;Collaborations;Complex;Cryoelectron Microscopy;Cytokinesis;Diglycerides;Disease;Electron Microscopy;endosome membrane;Enzymes;Event;Geometry;Goals;in vivo;insight;Invaded;Investigation;lipid phosphate phosphatase;Lipids;Mass Spectrum Analysis;Mediating;Membrane;Molecular;Monomeric GTP-Binding Proteins;mutant;Mutate;Nutrient;Pathway interactions;PH Domain;Phosphatidic Acid;phospholipase D2;Phosphotransferases;Physiological;Play;Process;Protein Kinase;Proteins;reconstitution;Recycling;Resolution;Role;Signal Transduction;Sorting;Structure;Surface;System;Techniques;Tissues;uptake;Validation;Vesicle;vesicle transport

PROJECT_TITLE: Mechanisms of endocytic recycling

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ORG_DEPT: NEUROSURGERY

PHR: After a brain bleeding, hematoma mass and blood components from the clot can cause blood-brain barrier disruption, brain edema formation, brain cell death and neurological deficits. The purposes of this project are to investigate the mechanisms of brain injury after hemorrhage and to develop effective therapies. The long-term goal of our studies is to limit brain damage following brain hemorrhage.

PI_NAMEs: XI, GUOHUA  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Blood;blood-brain barrier disruption;Brain;brain cell;Brain Edema;Brain hemorrhage;Brain Injuries;brain parenchyma;Cell Death;Cerebral hemisphere hemorrhage;Coagulation Process;Combined Modality Therapy;Cytolysis;Deferoxamine;Development;Disabling;effective therapy;Erythrocytes;Event;Excision;Goals;Hematoma;Hemoglobin;Hemorrhage;Human;Hydrocephalus;intraventricular hemorrhage;Iron;Neurologic Deficit;Patients;Phase II Clinical Trials;restoration;Role;Secondary to;Series;Stroke;Thrombin;Work

PROJECT_TITLE: Experimental Cerebral Hemorrhage: Mechanisms and Therapies


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Many neurological disorders such as stroke, spinal cord injury, Parkinson’s disease, and cerebral palsy manifest in a class of motor impairments called hyper-resistance characterized by increased joint resistance to passive motion that encompasses spasticity, rigidity, and dystonia. This project will identify poorly understood neural mechanisms of hyper-resistance, demonstrate how they may be identified through clinically feasible assessments, and develop predictive computational models to identify rational, individual-specific targets for novel treatments.

PI_NAMEs: COPE, TIMOTHY C;SAWICKI, GREGORY STEPHEN;TING, LENA H (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Address;Affect;Biological;biological systems;biomechanical model;Biomechanics;biophysical model;Biophysics;Cerebral Palsy;Clinical;Clinical assessments;clinically relevant;Computer Models;Consensus;Coupling;Data;Decerebration procedure;Diagnosis;Diagnostic;Disease;Dissociation;Dyskinetic syndrome;Dystonia;Electromyography;Funding;Goals;Health;Human;Hyperreflexia;Impairment;in silico;in vivo;Individual;insight;instrument;Joints;kinematics;Lead;Left;Leg;Limb structure;Measures;Mechanics;Methods;Modeling;Motion;Motor;motor impairment;Motor output;Movement;Movement Disorders;multi-scale modeling;Muscle;Muscle Fibers;Muscle Hypertonia;Muscle Spindles;Muscle Tension;Nervous System Disorder;Nervous System Physiology;neural;Neurologic;Neuromechanics;neuromechanism;neuromuscular;Neurosciences;novel;Organ;Parkinson Disease;Parkinsonian Disorders;Physics;predictive signature;Preparation;Property;Rattus;Research;Resistance;robotic system;Robotics;Role;Sensory;sensory input;Severities;Signal Transduction;simulation;spasticity;Spinal;Spinal cord injury;Stretching;Stroke;Symptoms;System;Tendon structure;Testing;Tissues;treatment strategy;Validation;virtual;virtual reality;Work

PROJECT_TITLE: Multiscale models of proprioceptive encoding to reveal mechanisms of impaired sensorimotor control


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative This project seeks to fill important gaps of knowledge in cell migration, which is essential for many physiological and pathological processes such as embryonic development, wound healing, and cancerous invasion. We will use a top-down approach that treats migrating cells as an integrated mechanical system, and we are developing technologies such as 3D printing and artificial intelligence for fabricating experimental environments, following cell movements, and imaging interactions in 3D scaffolds. Knowledge in how migrating cells interact with the environment and with each other is expected to further our abilities to counter diseases and restore body functions.

PI_NAMEs: WANG, YU-LI  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;3D Print;Area;Artificial Intelligence;Binding;Biological Models;Cancerous;Cell Communication;cell motility;Cell Polarity;Cell Shape;Cells;Cellular biology;Characteristics;Complement;Complex;Computer Models;Cues;Development;Disease;Embryo;Embryonic Development;Environment;Epithelial Cells;Experimental Models;experimental study;Filopodia;Geometry;Image;imaging approach;insight;Intercalated Cell;Invaded;Knowledge;Length;Lung;Machine Learning;Mechanics;Mediating;migration;Molecular;Morphogenesis;new technology;novel;Pathologic Processes;Periodicity;pharmacologic;Phase;Physiological Processes;polyacrylamide;polyacrylamide hydrogels;Process;Property;Relaxation;response;scaffold;sensor;Stretching;superresolution imaging;System;Tail;Technology;Testing;Tissue Engineering;tissue repair;Tissues;Traction Force Microscopy;wound healing

PROJECT_TITLE: Dissecting the mechanism of cell migration at the systems level

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Services;Lung;Lung Cancer;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative The purpose of the proposed renewal of this cancer education training project is to train oncology care providers to implement tobacco use assessment and treatment (TUAT) in their cancer care settings. This goal remains important because approximately 10-30% of cancer patients are smokers when diagnosed, and approximately 70% of patients will continue to smoke after their diagnosis. Building on the successful educational accomplishments of the past funding period, this project will implement and evaluate a TUAT skills development course and collaborative training initiative that will train and provide technical assistance to oncology care professionals to implement TUAT at their respective institutions.

PI_NAMEs: OSTROFF, JAMIE S. (contact)

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Acceleration;Address;Adoption;Agreement;anti-cancer research;Attitude;Basic Science;Behavior;cancer care;Cancer Care Facilities;cancer education;Cancer Education Grant Program;Cancer Patient;Cancer Survivor;cancer therapy;care delivery;care providers;Caring;Cessation of life;Chronic;Clinical;Clinical Practice Guideline;Clinical Research;cohort;collaboratory;Communities;Course Content;course development;Dedications;design;Diagnosis;Discipline;disorder risk;Education;education research;Educational Grants;Educational workshop;Enrollment;Evaluation;evidence base;Faculty;Feedback;Funding;Goals;Guidelines;Health;Hybrids;implementation barriers;implementation facilitation;improved;innovation;Institution;Knowledge;learning strategy;Light;Malignant Neoplasms;Medical;Modeling;modifiable risk;Morbidity - disease rate;mortality;multidisciplinary;National Comprehensive Cancer Network;NCI-Designated Cancer Center;Nurses;Oncologist;Oncology;Outcome;Participant;patient-level barriers;Patients;Persons;Pharmacists;practice setting;premature;Professional Organizations;programs;Provider;provider-level barriers;Psychologist;Quality of life;Recurrent disease;Reporting;Research;research to practice;Resources;respiratory;Risk;Risk Factors;Second Primary Cancers;Self Efficacy;Site;skill acquisition;skills;Smoke;Smoker;Smoking;smoking cessation;Social Workers;standard care;Surgeon;Surveys;system-level barriers;Time;Tobacco;tobacco cessation intervention;Tobacco Dependence;Tobacco use;Tobacco Use Cessation;Training;Training and Education;Training Programs;training project;Translational Research;treatment planning;treatment response;treatment services;Treatment-related toxicity;Update;videoconference;virtual

PROJECT_TITLE: Tobacco Treatment Training for Cancer Care Providers

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Obesity and its associated co-morbidities are major public health problems. In United States, more than 70% of adults are overweight or obese. Findings from these studies may lead to novel therapeutic approaches to the treatment of the obesity-related diseases.

PI_NAMEs: FUNAI, KATSUHIKO  (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Ablation;Affect;Affinity;Anabolism;ATP Synthesis Pathway;Binding;Cardiolipins;comorbidity;Complex;Cone;Consumption;cost;Crista ampullaris;Data;Diagnostic;diet-induced obesity;diminished oxidative phosphorylation;electron donor;electron energy;Electron Transport;Electrons;Electrophysiology (science);energy efficiency;Energy Metabolism;Energy Transfer;Enzymes;Exercise;exercise training;Exhibits;Fatty acid glycerol esters;Fluorometry;Genetic;improved;Inner mitochondrial membrane;lipidomics;Lipids;loss of function;Membrane;Membrane Lipids;Metabolic;metabolic phenotype;metabolic rate;Microscopy;Mitochondria;mitochondrial membrane;Modeling;mouse model;Mus;Muscle;Muscle Contraction;Muscle Mitochondria;novel therapeutic intervention;Obesity;Obesity associated disease;obesity treatment;oligomycin sensitivity-conferring protein;Organ;Output;overweight adults;Oxidative Phosphorylation;Physical activity;Process;Proton-Motive Force;Protons;Public Health;Reaction;Resolution;respiratory;Rest;Role;Shapes;Skeletal Muscle;Spirometry;Testing;Tissues;United States;Vesicle;voltage

PROJECT_TITLE: Mitochondrial membrane lipids and respiratory efficiency

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Depression;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative Utilizing data from three longitudinal birth cohorts, we will examine the impact of air pollution on the epigenome and the onset of childhood anxiety and depression symptoms. We will investigate DNA methylation biomarkers using an unbiased epigenome-wide approach to advance our understanding of potential molecular pathways involved in air pollution neurotoxicity and/or anxiety and depression pathophysiology. The findings of this study will help identify not only key molecular pathways but also significant markers and modifiable predictors of anxiety and depression which could be used to identify at-risk youth for anxiety and depression and better inform timed-interventions focused on reducing exposure to air pollution.

PI_NAMEs: BRUNST, KELLY J (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: 12 year old;5 year old;Accounting;Acute;Adolescence;Adolescent;Adult;Affect;Affective;Age;Air Pollutants;Air Pollution;ambient air pollution;Anxiety;anxiety symptoms;Area;Behavior;Behavioral;Biological;biomarker identification;Birth;Blood;Boston;Brain;Carbon Black;Central Nervous System;Characteristics;Child;child depression;Childhood;childhood anxiety;Chronic;Cognitive;cohort;Complex;Consent;CpG Islands;Cross-Sectional Studies;Data;depressive symptoms;Development;Diameter;Disease;disorder risk;DNA Methylation;DNA Sequence;Early Diagnosis;early onset;Elements;Environment;Environmental Exposure;epidemiology study;Epigenetic Process;epigenome;epigenomics;Etiology;Exposure to;fine particles;follow-up;Follow-Up Studies;Functional disorder;Future;Gene Expression;Genes;Genetic Transcription;Goals;Health;health assessment;health data;HIV/AIDS;Hypersensitivity;individual variation;Inflammation;Inflammatory;Inhalation;Intervention;late life;Life Cycle Stages;Link;Measures;Mental Depression;Mental disorders;Mental Health;Methylation;methylation biomarker;methylomics;Molecular;Monitor;myelination;Nature;neurodevelopment;neurotoxicity;novel marker;Obsessive-Compulsive Disorder;Olfactory Nerve;Outcome;oxidative damage;Oxidative Stress;Oxidative Stress Pathway;Particulate Matter;Pathway interactions;peripheral blood;Phenotype;Pollution;prenatal;prenatal exposure;Prevalence;Prevention;promoter;psychiatric symptom;Research;Research Design;Risk;Risk Factors;Role;Sampling;Separation Anxiety;Site;Social Phobia;sociodemographics;Stimulus;Stream;Substance abuse problem;suicidal;Suicide;Symptoms;Teenagers;Testing;traffic-related air pollution;ultrafine particle;Visit;Youth

PROJECT_TITLE: Epigenetics, air pollution, and childhood mental health

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: Newark

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Injury to the cochlea results in activation and infiltration of immune cells into the cochlea, where these cells play beneficial roles via fractalkine signaling in repairing damaged hair cell synapses and promoting long-term survival of spiral ganglion neurons (SGNs) that carry sound information to the brain. Our goal is to understand the mechanisms of fractalkine-mediated neuroprotection in the injured cochlea and to define the relationship between genetic mutations in human fractalkine signaling and noise-induced hearing loss. Knowledge gained from these studies will advance prevention of SGN loss and identify novel treatment strategies for successful cochlear implantation and help in identification of individuals who are at greater risk of hearing loss.

PI_NAMEs: KAUR, TEJBEER  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acceleration;Afferent Neurons;Aging;Animals;Anti-Inflammatory Agents;Auditory;Binding;Biological;Blood;Brain;Candidate Disease Gene;Cell Death;Cells;chemokine;Chemotaxis;clinically relevant;Cochlea;Cochlear implant procedure;Cochlear Implants;cochlear synaptopathy;CSF1R gene;CX3CL1 gene;cytokine;Data;deaf;density;Development;DNA Sequence Alteration;Elements;Exposure to;Fractalkine;Future;Genetic Polymorphism;Goals;Hair Cells;Hearing;hearing impairment;hearing loss risk;hearing restoration;Heterogeneity;Human;humanized mouse;Immune;immune cell infiltrate;Immunotherapy;Impairment;Individual;Inflammation;Inflammatory;inhibitor;injured;Injury;Innate Immune System;Inner Hair Cells;Knockout Mice;Knowledge;Lead;Ligand Binding;Ligands;Macrophage;Maps;Measures;Mediating;Methods;Molecular;monocyte;mouse model;Mus;Mutant Strains Mice;Natural Immunity;Natural regeneration;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;neuronal survival;Neurons;Neuropathy;neuroprotection;neurotoxic;Nitrogen;Noise;noise trauma;Noise-Induced Hearing Loss;normal hearing;novel;novel therapeutics;ototoxicity;Outcome;Oxygen;Pathology;Pathway interactions;Performance;Pharmaceutical Preparations;Play;Population;preservation;prevent;Prevention;Production;receptor;recruit;repaired;Residual state;response;Risk;Role;Sensorineural Hearing Loss;Signal Transduction;Single Nucleotide Polymorphism;sound;spiral ganglion;Structure;success;Synapses;Testing;therapy development;transmission process;treatment strategy;Variant

PROJECT_TITLE: Innate Immunity to Spiral Ganglion Neuron Degeneration

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health;Substance Misuse

ORG_CITY: HERSHEY

ORG_DEPT: PEDIATRICS

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative Neonatal abstinence syndrome (NAS), a withdrawal condition due to in utero drug exposure, affects over 32,000 newborns in the U.S annually, and its incidence continues to grow concurrent with the opioid crisis. The association between NAS and long-term neurodevelopment is largely unknown. This project will examine the relationship between NAS and longitudinal academic performance and explore targets for future interventions aimed at improving educational outcomes in children with a history of NAS.

PI_NAMEs: CORR, TAMMY E (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: 3 year old;Academic achievement;Academic Medical Centers;Accounting;Achievement;achievement test;Adult;Affect;Age;Age disparity;Biological;Biometry;career development;Caregivers;Caring;Child;Child Welfare;Childhood;Clinical;clinical practice;Clinical Research;Communities;Community Health;Complement;Complex;Conduct Clinical Trials;cost;Crime;Data;data warehouse;Databases;design;Deterioration;Development;Developmental Delay Disorders;Diagnosis;Drug Exposure;drug exposure in utero;early childhood;Early Intervention;Education;effective intervention;Environment;Epidemiology;Evaluation;experience;Family;Foundations;Future;Generations;Goals;Grant;Health;Health Care Rationing;health economics;Illicit Drugs;improved;improved outcome;in utero;inattention;Incidence;Individual;Infant;Influentials;Information Systems;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;Learning;Link;Measures;Mentorship;Methodology;Methods;Mothers;Neonatal;Neonatal Abstinence Syndrome;neonate;neurodevelopment;Newborn Infant;Nursery Schools;Opioid;opioid epidemic;Outcome;Parents;patient oriented;Pennsylvania;Performance;Physicians;Policies;postnatal;Pregnant Women;Problem behavior;Productivity;Public Health;Race;Recording of previous events;Reporting;Research;research and development;Research Design;Research Methodology;Research Personnel;Resolution;Resources;Risk;School-Age Population;Schools;Scientist;Services;Severities;sex;Social Environment;Social Welfare;Socioeconomic Factors;Special Education;success;Symptoms;Syndrome;Testing;Time;Toddler;Training;Translating;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Withdrawal

PROJECT_TITLE: Longitudinal Academic Performance in Children with a History of Neonatal Abstinence Syndrome

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: MADISON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The proposed study aims to answer the fundamental questions of how bacteria utilize a compendium of signaling nucleotides to adapt to their specific environmental niches and to survive fluctuating environments. We combine metabolomics and proteomics with genetic, biochemical and biophysical approaches to study how stress-signaling nucleotides (p)ppGpp, pGpp, (p)ppApp and AppppA regulate cellular processes including metabolism and development in response to nutritional, temperature and antibiotic stresses. Our goal is to establish fundamental principles using model organisms such as the Gram-positive bacterium Bacillus subtilis and apply our research to pathogenic bacteria to solve global issues including widespread antibiotic resistance in pathogens.

PI_NAMEs: WANG, JUE D. (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Antibiotic Resistance;antibiotic tolerance;Antibiotics;antimicrobial;assault;Bacillus;Bacillus anthracis;Bacillus subtilis;Bacteria;bacterial fitness;Biochemical;Biological;biological adaptation to stress;biophysical techniques;Cell Physiology;Cell Wall;Cells;Cues;Development;diadenosine tetraphosphate;Environment;Enzymes;Evolution;experience;fitness;Genetic;genetic manipulation;Genetic Transcription;genome integrity;Goals;Gram-Positive Bacteria;Growth;Homeostasis;Knowledge;Laboratories;Life Style;Mediating;Metabolism;metabolomics;Microbial Biofilms;model organism;Nucleotides;Nutrient;Nutritional;pathogen;pathogenic bacteria;Physiological;Process;Proteome;Proteomics;Purines;Regulation;Research;Resistance;response;Role;Signal Transduction;Starvation;Stress;Temperature;Transcription Repressor;Transcriptional Regulation;transcriptomics;transmission process

PROJECT_TITLE: The critical roles of (p)ppGpp in homeostasis and antibiotic tolerance in Gram positive bacteria


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Urologic Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: We will assess how two different chemotherapy regimens with therapeutic equipoise, MVAC and GC, affect the immune microenvironment of bladder cancer as well as assess their ability to potentiate the effects of immune checkpoint blockade.

PI_NAMEs: KIM, WILLIAM Y. (contact);VINCENT, BENJAMIN G

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Adjuvant Chemotherapy;Adriamycin PFS;Affect;anti-PD-1;anti-PD-L1;anti-PD-L1 antibodies;anti-PD1 therapy;Antigens;Antineoplastic Agents;Bladder Neoplasm;bladder transitional cell carcinoma;Bladder Urothelium;Blood specimen;Cancer Patient;cancer therapy;Carboplatin;CD8-Positive T-Lymphocytes;Cells;Cessation of life;checkpoint inhibition;checkpoint therapy;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;Cisplatin;Clinical;Clonality;Combination Drug Therapy;Combination immunotherapy;cost;Cystectomy;Data;Disease;Dose;Equipoise;Fibroblasts;gemcitabine;Gene Expression Profile;genetic signature;Immune;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immunotherapy;improved;improved outcome;Individual;Laboratories;Level of Evidence;Malignant neoplasm of urinary bladder;Malignant Neoplasms;men;Methotrexate;Modality;molecular subtypes;mouse model;Muscle;muscle invasive bladder cancer;Neoadjuvant Therapy;neoantigens;novel;Patients;PD-1/PD-L1;PDL1 inhibitors;peripheral blood;permissiveness;phase II trial;Platinum;Progression-Free Survivals;Prospective cohort;Publishing;Randomized;randomized, clinical trials;Regimen;Resistance;response;Sampling;Schedule;Side;Specific qualifier value;Survival Rate;T cell response;T-Cell Receptor;Testing;TGFB1 gene;Therapeutic;transcriptomics;Transitional Cell Carcinoma;Treatment Protocols;tumor;tumor microenvironment;tumor-immune system interactions;United States;Urothelium;Vincristine

PROJECT_TITLE: Chemotherapy and the Bladder Cancer Immune Microenvironment

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]