NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Obesity;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE This project will provide an in-depth analysis of our previously-developed metabolic syndrome (MetS) severity z-score across a wide array of racial/ethnic and sexual/gender subgroups. We will first evaluate for unique features of metabolic syndrome across different populations, producing unique scoring if needed or continuing with already-derived scores if not needed. We will then assess both for 1) how social determinants of health (SDOH) are related to MetS severity for each group, and 2) how MetS severity is related to longitudinal risk for CVD—providing tools for a more personalized approach to measuring cardiometabolic risk across the entire U.S. population, as well as a validated tool for other All of Us researchers to use.

PI_NAMEs: DEBOER, MARK DANIEL;GURKA, MATTHEW JAMES (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Affect;African American;African American population;Age;age effect;Asian Americans;Attention;Biomedical Research;Body mass index;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;Characteristics;Chronic stress;Clinical;Clinical assessments;clinical care;clinical practice;cohort;Data;depressive symptoms;Derivation procedure;diabetes risk;Discrimination;Disease Outcome;disorder risk;Early Intervention;Electronic Health Record;Ethnic Origin;Ethnic Population;Evaluation;Factor Analysis;Formulation;Future;Gender;Goals;Health;Health Personnel;Hispanic;Hispanic Populations;improved;Individual;innovation;Insulin Resistance;interest;Link;marginalization;Measures;Medical;Metabolic;Metabolic syndrome;Minority Groups;mortality;National Health and Nutrition Examination Survey;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Outcome;Outcomes Research;Participant;Patient Self-Report;Pattern;perceived discrimination;personalized approach;personalized medicine;Physiological;Population;Prevalence;prevent;Preventive care;preventive intervention;Process;psychosocial stressors;Questionnaires;Race;racial difference;racial minority;Research;Research Personnel;research study;Risk;Risk Assessment;Risk Factors;risk prediction;risk stratification;Role;Severities;sex;Sexual and Gender Minorities;social factors;social health determinants;social stress;Stress;Subgroup;Time;tool;Underrepresented Populations;Validation;Work

PROJECT_TITLE: Metabolic Syndrome Severity in All of Us: Relationship with Social Determinants of Health and with Long-Term Risk for Cardiovascular Disease


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Diabetes;Nutrition;Pediatric;Prevention

ORG_CITY: WASHINGTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: The main objective of this award is to recruit, retain, and mentor trainees from backgrounds underrepresented in medicine into research career pathways that will ultimately help support our nation's biomedical and behavioral workforce goal of increasing and diversifying the pipeline of diabetes researchers. This opportunity will provide research training under the mentorship of a recognized and dedicated researcher with a well- established track record of NIH funding. This mentoring relationship holds the potential to favorably impact career trajectories of underrepresented students and fellows and help close America's gap in training a diverse biomedical and behavioral diabetes research workforce to improve clinical and public health outcomes.

PI_NAMEs: STREISAND, RANDI  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Acceleration;Adherence;Advisory Committees;African American population;Alaska Native;American Indians;Area;Award;behavior change;Behavioral;behavioral and social science;behavioral outcome;Behavioral Research;Behavioral Sciences;Biomedical Research;Black American;Capital;career;Career Choice;Caring;Child;Childhood;Childhood diabetes;Clinical;Clinical Research;clinical translation;Communities;community engagement;Competence;Complications of Diabetes Mellitus;Consultations;Country;Coupled;cultural competence;deaf;Dedications;Development;Diabetes Mellitus;diabetes self-management;dietary;Dimensions;Disabled Persons;disadvantaged background;Discipline of Nursing;Disease;Disease Management;Disparity;Disparity population;Diverse Workforce;Doctor of Philosophy;Education;Educational workshop;Ensure;Epidemiology;expectation;experience;Extramural Activities;Family;Fostering;Funding;glycemic control;Goals;graduate student;Grant;hard of hearing;Health;Health and Behavior in Children;Health Services Research;Healthcare;Hispanic Populations;Historically Black Colleges and Universities;Hospitals;Impairment;improved;Individual;innovation;Institution;Insulin-Dependent Diabetes Mellitus;interest;Internships;Intervention;Investments;Knowledge;Latino Population;Leadership;Learning;Life;Location;Medicine;member;Mentors;Mentorship;Mission;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Native Hawaiian or Other Pacific Islander;next generation;Outcome;Parents;Patient Care;pediatric patients;pediatrician;Pharmacy facility;Physical activity;Postdoctoral Fellow;prevent;Prevention;Professional Education;programs;Psyche structure;Public Health;recruit;Recruitment Activity;Regimen;Research;Research Methodology;Research Personnel;Research Training;Resources;Role;Science;Scientist;Self Care;Series;Services;skills;social;Structure;Students;Technology;theories;Thinking;Training;Training and Education;Treatment Protocols;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Washington;Women's study

PROJECT_TITLE: I-TrainED: Innovative Training and Education in Diabetes


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Beta cell dysfunction and death are significant pathologies underlying the development of Type 2 diabetes. The PI will train and mentor students from diverse backgrounds in projects focused on understanding how SARS- CoV-2 infection affects beta cell survival, metabolism, and function. This research and mentoring experience will prepare trainees to be the next generation of investigators by engaging in experiments to understand the molecular basis of a pressing public health issue that may afflict a significant number of patients who have recovered from COVID19.

PI_NAMEs: GEORGIA, SENTA K (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Address;Affect;African American Women;Animal Model;Animals;Atrophic;Autopsy;Award;Awareness;Beta Cell;Biological Models;Biological Sciences;Biomedical Research;blood glucose regulation;Cadaver;capsule;career;Career Mobility;career preparation;Cell Physiology;Cell Reprogramming;Cell Respiration;Cell Survival;Cellular Metabolic Process;Cessation of life;Clinical;clinical phenotype;clinically relevant;Competence;COVID-19;COVID-19 impact;COVID-19 pathogenesis;COVID-19 patient;COVID-19 survivors;Data;Development;Diabetes Mellitus;diabetes pathogenesis;Diabetic Ketoacidosis;Disease;Education;empowerment;Environment;experience;experimental study;Face;Functional disorder;Future;Glucose;Goals;graduate student;Health;Human;Hyperglycemia;improved;In Vitro;in vivo;in vivo Model;Infection;Injury;innovation;insight;Insulin;insulin secretion;islet;Islets of Langerhans Transplantation;Kidney;Laboratories;Literature;Long COVID;long term consequences of COVID-19;long term recovery;Los Angeles;Macaca mulatta;Measures;Mediating;Mentors;Metabolic;Metabolism;Mission;Mitochondria;Modeling;Molecular;Morphology;Mus;next generation;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;Odds Ratio;Outcome;Pancreas;Paper;Pathogenesis;Pathology;Patients;Pediatric Hospitals;Physiological;Post-Acute Sequelae of SARS-CoV-2 Infection;post-transplant;Predisposition;Prevalence;Principal Investigator;programs;Public Health;Reporting;Reproducibility;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resolution;Respiratory System;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;Secondary to;severe COVID-19;skills;small molecule;Stress;Structure;Structure of beta Cell of islet;student mentoring;Study models;Symptoms;Techniques;Testing;Time;time use;Training;Transplantation;Viral Pathogenesis

PROJECT_TITLE: Mentoring Emerging Researchers at CHLA (MERCH-LA)


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: Although screening colonoscopy can reduce colorectal cancer (CRC) incidence and mortality, there is considerable variability in individual risk of CRC. Better CRC risk estimates could improve CRC prevention through personalized approaches to the timing, modality (colonoscopy or non-invasive options) and frequency of screening and follow up. To achieve this goal, we need risk prediction models that incorporate individual clinical factors and screening history (if available) with genetic information for each Veteran. This CDA proposal seeks to build an accurate database of Veterans who developed CRC and advanced precancerous lesions, link this database to the Million Veteran Program to expand genetic discovery across diverse populations, and create an equitable tool for personalized assessments of CRC risk. More precise CRC risk stratification will improve CRC prevention by better targeting colonoscopy resources to the individuals at increased risk for CRC, while reducing the costs and harms of invasive screening and follow up in those at low risk.

PI_NAMEs: SULLIVAN, BRIAN ANDREW (contact)

PROJECT_TERMS: Adherence;administrative database;age effect;Algorithms;analytical tool;Asian ancestry;Award;biobank;Bioinformatics;Cancer Etiology;cancer genomics;cancer prevention;career;career development;Cessation of life;Cladribine;Classification;Clinical;clinical biomarkers;clinical database;clinical epidemiology;clinical risk;Code;cohort;Colonoscopy;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;cooperative study;cost;cost effective;Data;data acquisition;data integration;data warehouse;Databases;design;Development;Development Plans;Diagnosis;Directories;Disease;Disparity;disparity reduction;Doctor of Medicine;Effectiveness;Ensure;epidemiology study;Equity;Ethnic Origin;European ancestry;experience;follow-up;Frequencies;Funding;Future;Genetic;genetic analysis;genetic epidemiology;genetic information;Genetic Risk;genetic risk factor;genome wide association study;genomic biomarker;Genomics;Goals;Guidelines;health care service utilization;Health Promotion;high risk;high risk population;implementation study;improved;improved outcome;Incidence;Individual;Inequity;Interdisciplinary Study;Lesion;Link;Longitudinal cohort;Malignant Neoplasms;Measures;Medical center;Medicine;Mentors;Mentorship;Methodology;Methods;military veteran;Minority;Modality;mortality;mortality risk;multi-ethnic;multidisciplinary;Natural Language Processing;Neoplasms;novel;novel strategies;Outcome;outcome disparities;Patients;Personal Satisfaction;personalized approach;personalized risk prediction;personalized screening;phenotyping algorithm;Physicians;polygenic risk score;Population Heterogeneity;Population Programs;precision oncology;predictive tools;premalignant;Procedures;professor;programs;prospective;Qualifying;Race;racial disparity;racial diversity;Recommendation;Recording of previous events;repository;Research;Research Personnel;Resources;Risk;Risk Assessment;Risk Estimate;Risk Factors;risk prediction;risk prediction model;risk stratification;Scientist;screening;Statistical Models;Testing;Time;tool;tool development;Training;Triage;tv watching;Underrepresented Populations;United States;Universities;uptake;validation studies;Veterans;Wages;Work

PROJECT_TITLE: Personalized Colorectal Cancer Prevention: Integrating Individual Screening and Follow Up Information with Genetic Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ONCC-S (01)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Eating Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Standard care for obesity produces minimal weight loss and weight regain is common. An innovative behavioral treatment, acceptance-based therapy (ABT), focuses on self-regulation skills and increasing mindfulness and tolerance of negative or uncomfortable emotions and is highly effective for weight loss in adults. Our study team has developed and tested an ABT weight loss intervention for adolescent girls and the objective of this proposal is to randomize adolescent girls with OW/OB to an ABT versus an Enhanced Care (EC) intervention to test the efficacy of an ABT intervention on physiological, behavioral, and psychological factors related to cardiometabolic health.

PI_NAMEs: MANASSE, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: 19 year old;Accelerometer;acceptability and feasibility;Adherence;Adolescent;Adult;Affect;Aftercare;Anorexia;anxiety sensitivity;Behavior Therapy;Behavioral;behavioral outcome;Biological;blood lipid;Blood Pressure;blood pressure reduction;Body Composition;Body fat;Body mass index;Body Weight decreased;Cardiometabolic Disease;cardiometabolism;cardiovascular disorder risk;chronic pain;Clinical Trials;community clinic;craving;Cues;Demographic Factors;demographics;Development;Devices;Diet;dietary;Dietary intake;Disinhibition;Eating Behavior;Eating Disorders;Educational process of instructing;Effectiveness;efficacy testing;Emotions;enhanced care;ethnic minority;Ethnic Origin;Exhibits;experience;Feasibility Studies;feasibility testing;Female Adolescents;flexibility;follow-up;Foundations;girls;Goals;Habits;Health;Health behavior;healthy lifestyle;high risk;high risk sexual behavior;Hour;Hybrids;Hyperphagia;improved;individualized medicine;Informal Social Control;innovation;Institutional Review Boards;Intervention;intervention effect;lifestyle intervention;Maintenance;Manuals;Measures;Mediating;Mental Depression;Meta-Analysis;mindfulness;Modality;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity treatment;operation;Outcome;Outpatients;Overweight;Participant;Patient Recruitments;Perceived quality of life;Persons;Phase;Physical activity;Physiological;Policies;Population Heterogeneity;Prevention;primary outcome;Procedures;Progress Reports;psychologic;Psychological Factors;psychological outcomes;Quality of life;Race;racial diversity;racial minority;Randomized;Randomized, Controlled Trials;recruit;Remote session;restraint;Risk Factors;secondary outcome;sedentary lifestyle;skills;Sleep;Socioeconomic Status;standard care;success;Teacher Professional Development;Testing;Therapeutic Intervention;therapy development;Time;Time Study;tool;treatment comparison;trial comparing;United States;United States National Institutes of Health;Weight;weight loss intervention;Work

PROJECT_TITLE: Wellness Achieved Through Changing Habits (WATCH): An Acceptance-Based Healthy Lifestyle Intervention for Diverse Adolescents

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Staphylococcus aureus infections occur commonly in Veterans, both in outpatients as well as hospitalized patients. The VA healthcare system is one of the largest healthcare systems in the US, with over 5 million people served per year. Among Veterans, S. aureus is the most common cause of skin and soft tissue infections, and these infections are becoming harder to treat due to high level antimicrobial resistance. Our studies will provide insight on mechanisms used by methicillin-resistant S. aureus (MRSA) to colonize the skin and transition to systemic infection. Understanding colonization mechanisms could improve treatment options for skin and soft tissue infections.

PI_NAMEs: HORSWILL, ALEXANDER R (contact)

PROJECT_TERMS: active duty;acute infection;Address;Adherence;Adult;anti-microbial peptide;Antibiotic Resistance;Antimicrobial Resistance;Bacterial Adhesins;Biological Assay;Biological Markers;Blood Circulation;Cell Line;chronic infection;Clinical;Collection;Development;Disease;Environment;exoenzyme;Fatty Acids;Genetic Transcription;Healthcare Systems;high risk;Hospitalization;Human;Immune Evasion;Immunity;improved;In Vitro;Infection;infection burden;infection risk;Infectious Skin Diseases;inhibitor;innovation;insight;Invaded;keratinocyte;Life Style;Medical;Membrane Proteins;Methicillin;methicillin resistant Staphylococcus aureus;Microbial Biofilms;Microscopy;Military Personnel;Modeling;mouse model;Mus;mutant;Natural Immunity;neutrophil;novel;opportunistic pathogen;Outpatients;pathogen;Pathway interactions;Patients;Persons;pH Homeostasis;polymicrobial biofilm;Predisposition;prevent;Prevention;programs;Proteins;quorum sensing;Regulatory Pathway;Resistance;resistance mechanism;response;Risk Factors;Role;service member;Skin;Skin colonization;Soft Tissue Infections;Staphylococcus aureus;Staphylococcus aureus infection;Surface;System;Systemic disease;Systemic infection;Testing;Therapeutic;Toxin;transcriptome;transcriptome sequencing;United States Department of Veterans Affairs;Up-Regulation;Urease;Veterans;Virulence;Virulence Factors;wound healing

PROJECT_TITLE: Quorum Sensing Dependent Interactions with Biofilms and Innate Immunity Defense

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 INFB-K (01)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative In 2023, multiple attribute-specific and intersecting stigmas are critical determinants of poor mental and sexual health of communities at risk for and living with HIV; however, most HIV-related health interventions continue to focus on individual risk behavior. The disconnect between recognizing stigma as a social determinant of health and barrier to HIV interventions and intervention efforts has often been cited as arising from limited capacity of domestic and international investigators to appropriately measure complex stigma processes and develop methodologically sound effectiveness and implementation studies of interventions grounded in theory and lived experience that aim to reduce or mitigate stigma and its harms. In response, we are proposing to develop the Johns Hopkins-Emory-developmental AIDS Research Center (JH-E-dARC) to build capacity for the measurement of stigma and development of interventions focused on responding to stigma as a threat to both mental health and suboptimal individual and population-level HIV outcomes in the US and around the world.

PI_NAMEs: BARAL, STEFAN DAVID (contact);SULLIVAN, PATRICK SEAN

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Academia;Acquired Immunodeficiency Syndrome;Address;Affect;Anxiety;Applications Grants;Awareness;Communication;Communities;Community Health;Complex;Data;Dedications;Dependence;design;Development;Disclosure;effectiveness study;Epidemic;epidemiology study;Evidence based intervention;Experimental Designs;Foundations;Funding;Goals;Health;HIV;implementation study;improved;Individual;Institution;Institutional Review Boards;International;Intervention;Intervention Studies;Knowledge;Label;Lead;Learning;Lived experience;Maryland;Measurement;Measures;Mental Depression;Mental Health;Mentorship;Methodology;Methods;multidisciplinary;National Institute of Allergy and Infectious Disease;National Institute of Mental Health;Observational Study;Outcome;Output;Pathway interactions;personalized approach;Population;Process;Proliferating;Public Health;Public Health Schools;Quasi-experiment;Research;research and development;Research Design;Research Personnel;Resources;response;Risk;Risk Behaviors;Science;Scientist;Sexual Health;social health determinants;social stigma;sound;structural determinants;Structure;theories;therapy development;United States National Institutes of Health;Universities;USAID;web site;Work

PROJECT_TITLE: Creating a developmental AIDS Research Center focused on improving the measurement of and response to stigma and structural determinants in the HIV response

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (03)]


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention

PI_NAMEs: BARAL, STEFAN DAVID (contact)

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

PI_NAMEs: SCHWARTZ, SHEREE RENAE (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Area;Attention;Award;career development;Collaborations;Communities;community academic partnership;Community Actions;community engagement;Community of Practice;community partners;Compensation;Computer software;Data;data repository;Data Set;Development;Discrimination;empowerment;Ensure;Epidemic;Equity;experience;Fellowship;Fostering;Funding;Funding Opportunities;Future;gaps in access;Grant;Grant Review;Health;health equity;Health equity research;HIV;implementation science;improved;innovation;Intervention;Investments;Journals;Leadership;Manuscripts;marginalization;Measurement;Measures;meetings;Mentorship;Modeling;multidisciplinary;Nature;next generation;Outcome;Phase;Population;Prevention;Process;Proliferating;Public Health Education;Reporting;Research;Research Personnel;Research Proposals;response;rural setting;Science;Scientific Advances and Accomplishments;Scientist;Series;service providers;Services;Sexual and Gender Minorities;social stigma;Stigmatization;structural determinants;structural health determinants;success;symposium;synergism;System;Text;Training Programs;Universities;urban setting;Vertebral column;Woman;Work;Writing

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

PI_NAMEs: MURRAY, SARAH SUTHERLIN-MCIVOR (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Alcohol dependence;Anxiety;Area;Behavior;Biometry;community advisory board;Development;Diagnosis;empowerment;Engineering;Epidemic;epidemic response;Epidemiology;epidemiology study;experience;Faculty;Feedback;Fostering;gender minority health;Goals;Grant;Grant Review;health inequalities;Health Sciences;high risk;HIV;implementation science;improved;Individual;Injecting drug user;Institution;interdisciplinary collaboration;Intervention;Intervention Studies;Libraries;Manuals;Measurement;Measures;meetings;Mental Depression;Mental Health;Mentorship;Methods;minority stressor;multidisciplinary;Outcome;Pathway interactions;Persons;Pharmaceutical Preparations;Population;Preparation;Prevention;Process;programs;Proliferating;Research;Research Personnel;response;Services;sex;Sexual and Gender Minorities;skills;Social Sciences;social stigma;Standardization;structural determinants;substance use;System;Testing;tool;Universities;Validation

PROJECT_TITLE: Stigma Measurement Core


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention

PI_NAMEs: WILLIE, TIARA C. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Active Learning;Address;AIDS prevention;Applications Grants;Area;Awareness;base;Behavior Therapy;Behavioral;Collaborations;Communities;community organizations;Development;Effectiveness of Interventions;effectiveness study;Evaluation;evidence base;Evidence based intervention;experience;Faculty;Feedback;Fostering;Foundations;Goals;HIV;HIV/AIDS;implementation study;improved;Infrastructure;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;interest;International;Intervention;Intervention Studies;Knowledge;Link;Maryland;Measurement;meetings;Mentors;Methodology;Outcome;Prevention;Process;Productivity;programs;Public Health;repository;Research;Research Design;Research Personnel;response;Schools;Scientist;senior faculty;Services;social stigma;Solid;structural determinants;Structure;Students;symposium;therapy design;tool;Training;Universities;Update;webinar

PROJECT_TITLE: Stigma Intervention Core


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: This work aims to improve the health and functional independence of Veterans with severe motor disabilities caused by neurologic injuries or diseases, such as spinal cord injury (SCI) or amyotrophic lateral sclerosis (ALS). Veterans account for approximately 18% of the 296,000 people affected by SCI nationally. Approximately 17,900 SCI cases occur annually in the U.S, causing tetraplegia in more than half. High tetraplegia profoundly inhibits independence in the most basic of tasks, including personal care. More than 27,000 Veterans with SCI are provided with care through the VAA; however, full recovery is achieved in less than 1% of all cases. This project directly benefits Veterans by addressing the reliability of intracortical brain–machine interfaces (BMIs) (an important RR&D priority area) by improving neuroinflammatory response and developing translational strategies for minimizing risks associated with post-implantation infection, device failure and systemic administration of antibiotics (i.e., toxicity, systemic side effects and emergence of resistant bacteria).

PI_NAMEs: AMANI HAMEDANI, HODA  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acute;Address;Affect;Amyotrophic Lateral Sclerosis;Animals;Anti-Bacterial Agents;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Effect;Area;Back;Bacteria;Bacterial Antibiotic Resistance;bacterial resistance;Blood;Blood - brain barrier anatomy;Blood Circulation;Brain;brain machine interface;brain tissue;Caring;Cephalic;Characteristics;Chronic;Craniotomy;Data;Development;Devices;Equipment Malfunction;Escherichia coli;Exposure to;functional independence;Genetic Markers;Growth;Harvest;Health;Histologic;Human;Implant;implantation;improved;in vivo;Infection;Infiltration;insight;Invaded;Investigation;local drug delivery;Mechanics;Methods;microbiome;Microelectrodes;microorganism;migration;Motor disability;Mus;Nanotubes;Nervous System Disorder;Nervous System Trauma;neuroinflammation;Operative Surgical Procedures;Outcome;Penetration;Performance;Persons;Pilot Projects;Population;Population Control;prevent;Process;Property;Proteomics;Quadriplegia;Recovery;response;risk minimization;Role;Self Care;Side;side effect;Signal Transduction;Site;Source;Spinal cord injury;Staphylococcus aureus;Sterilization;Surface;Surgical incisions;Systemic infection;Tissues;Titania;Toxic effect;translational approach;Treatment outcome;treatment planning;Veterans;Work

PROJECT_TITLE: Antimicrobial Coating for Intracortical Microelectrodes

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This intervention development research project will strengthen evidence-based strategies to improve mental health and HIV medication adherence for MSM in South Africa. The population focus represents one of the highest priority populations for HIV intervention in sub-Saharan Africa and one that also experiences high risk for mental health problems. The intervention addresses crucial gaps in HIV science and is designed to enhance scalability and implementation in complex service delivery settings in LMIC settings.

PI_NAMEs: OPERARIO, DON  (contact);SANDERS, EDUARD

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Address;Adherence;Africa South of the Sahara;AIDS prevention;antiretroviral therapy;Anxiety;arm;Biological;care outcomes;Caring;Characteristics;Cities;Clinic;Clinical Trials;Communities;comparison intervention;Complex;Continuity of Patient Care;Control Groups;Counseling;Country;design;Development;Dimensions;efficacy evaluation;Enrollment;Epidemic;evidence base;Evidence based program;experience;Feedback;Friendships;Future;General Population;Goals;Health Professional;high risk;HIV;HIV risk;implementation research;improved;Incidence;Infrastructure;innovation;interest;Intervention;intervention effect;Intervention Studies;Lesbian Gay Bisexual Transgender Intersex;low and middle-income countries;Manuals;Mediator;medication compliance;member;men who have sex with men;Mental Depression;Mental Health;mental training;minority stress;minority stressor;Oral;Outcome;Participant;Patient Self-Report;peer;Persons;Pharmaceutical Preparations;Phase;pilot test;pilot trial;Population;pre-exposure prophylaxis;Prevalence;Prevention program;prevention service;primary outcome;Problem Solving;problem solving therapy;Process;process evaluation;programs;Protocols documentation;psychological outcomes;Psychosocial Assessment and Care;Public Health;Qualitative Evaluations;Qualitative Research;Quantitative Evaluations;Randomized;randomized trial;Readiness;Research;Research Project Grants;Resources;Risk;Science;secondary outcome;segregation;service delivery;Services;Social Environment;social factors;social stigma;Social support;South Africa;South African;Southern Africa;Specimen;standard care;standard of care;Testing;theories;therapy development;Training;treatment program;treatment services;Universities;uptake;Well in self;Wellness coaching;World Health Organization

PROJECT_TITLE: Addressing mental health and medication adherence among MSM in South Africa

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: This proposal addresses a significant health problem globally and in the US Veteran community, which is the bone disease induced by diabetes (DM). The American Diabetes Association declared this disease a nationwide epidemic. Within the general population, 1 year after suffering a hip fracture, 25% of patients will die, 30% will suffer a permanent disability, and 40% will be unable to walk independently. Diabetic patients exhibit >30% in- crease in bone fracture risk compared to non-diabetics. Thus, morbidity and mortality due to bone fractures is significantly augmented in DM. Successful completion of the proposed studies will reveal novel genes, pathways, and cells to be therapeutically targeted downstream of the PTH1R signaling pathway to restore skeletal health in the frame of DM.

PI_NAMEs: BELLIDO, TERESITA M. (contact)

PROJECT_TERMS: Address;Advanced Glycosylation End Products;Affect;Aging;Agonist;American;Anabolic Agents;Anabolism;antagonist;Antibodies;Apoptosis;Architecture;ATP binding cassette transporter 1;Award;Binding;Biochemistry;Biology;bone;Bone callus;bone cell;Bone Diseases;bone fragility;bone health;bone loss;Bone Marrow Cells;bone mass;Bone Matrix;bone quality;Bone Regeneration;Bone remodeling;bone repair;Bone Resorption;bone strength;Book Chapters;cancer cell;Cancer Cell Growth;career;Cartilage;cell growth;Cells;Cholesterol;Clinical;clinical investigation;Clinical Management;Collaborations;Communities;Complex;CYBA gene;Deterioration;Diabetes Mellitus;diabetic;diabetic patient;Diagnosis;Disease;Distress;Early Diagnosis;Endocrinology;Ensure;Epidemic;Exhibits;Family;FDA approved;Fracture;fracture risk;fragility fracture;Functional disorder;Gene Expression;General Population;Genes;Genetic;Glucocorticoids;Glycosaminoglycans;Health;Health Care Costs;Healthcare;High Prevalence;Hip Fractures;hip replacement arthroplasty;Histology;hormonal signals;Hormones;Hospitals;Human;Hyperglycemia;improved;in vivo;Individual;inhibitor;insight;Journals;Knockout Mice;Knowledge;Lifelong disability;Ligands;Ligase;Liver X Receptor;loss of function;Malignant Neoplasms;mechanical load;Mechanical Stimulation;mechanical stimulus;Mediating;Minerals;Modeling;Molecular;Molecular Biology;Morbidity - disease rate;mortality;Multiple Myeloma;Mus;Muscle Weakness;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal Pain;Musculoskeletal System;Names;nano-string;non-diabetic;notch protein;novel;novel strategies;Oral;Osteocytes;Osteogenesis;Osteopenia;Osteoporosis;Osteoporosis prevention;Parathyroid Hormone Receptor;parathyroid hormone-related protein;Pathway interactions;Patients;Peer Review;Persons;pharmacologic;phrases;Population;Pre-Clinical Model;prevent;Prevention approach;programs;Property;Proteins;PTH gene;Publishing;Receptor Signaling;Research;Research Personnel;research study;restoration;Role;Science;Scientist;Seminal;side effect;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skeletal;Skeleton;standard of care;System;Techniques;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Tissues;TNFSF11 gene;tool;transcriptome;transcriptomics;treatment effect;treatment strategy;United States National Academy of Sciences;Veterans;Visit;Walking;Water;Work

PROJECT_TITLE: BLRD Research Career Scientist Award Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 RCSR-N (01)]


PHR: American Veterans are disproportionately affected by kidney-damaging agents during deployment operations, and failing health and medical countermeasures add long-term health effects eventually causing acute renal injury. Our studies showed that the kidney has a way of damaging and protecting itself by the interplay of two enzymes, one of which, DNase I, is responsible for the injury, while another, EndoG, provides protection of kidney cells by inactivating DNase I. Here, we propose testing out recently discovered DNase I and EndoG inhibitors to protect against these disturbances in the kidney. This study will likely result in new therapies providing short-term protection of the kidney immediately after injury, and may eventually allow saving human lives, improve the health of Veterans, and decrease the number of disabilities in the Veteran population.

PI_NAMEs: BASNAKIAN, ALEXEI G (contact)

PROJECT_TERMS: Acute;Acute Kidney Failure;Acute Renal Failure with Renal Papillary Necrosis;Admission activity;Affect;Alternative Splicing;American;Apoptotic;Cell Death;cell injury;Cell Nucleus;Cells;Chemicals;Cisplatin;clinically relevant;Cultured Cells;Cytoplasm;Data;Deoxyribonuclease I;Deoxyribonucleases;Development;disability;DNA;DNA biosynthesis;DNA Fragmentation;endonuclease;endonuclease G;Enzymes;Epithelial Cells;Epithelium;Event;Excretory function;Exposure to;expression vector;Extravasation;Fluorescence;Funding;Future;gene cloning;General Population;Genes;Grant Review;Health;Healthcare;Hemodialysis;Hemolysis;Human;improved;In Vitro;in vitro Model;in vivo;indexing;Individual;inhibitor;Injury;Injury to Kidney;Intervention;Ischemia;Kidney;kidney cell;Kidney Transplantation;Knockout Mice;Knowledge;Laboratories;Life;Link;Measurement;Measures;Mediating;medical countermeasure;Military Personnel;military veteran;Mitochondria;Modeling;mRNA Precursor;Mus;Muscular Atrophy;Mutate;Myoglobin;novel;novel therapeutics;Nuclear;nuclease;operation;Organ;pathogen;Pathway interactions;Pharmaceutical Preparations;prevent;Prevention strategy;Prognosis;Proteins;Regulation;Reperfusion Therapy;Reporting;Research;Rhabdomyolysis;Ribonucleases;RNA;RNA chemical synthesis;RNA Splicing;Role;Scheme;Skeletal Muscle;Small Interfering RNA;Testing;Therapeutic;therapeutic target;Tissues;tool;Toxic Environmental Substances;Toxin;Tubular formation;United States;Veterans;weapons

PROJECT_TITLE: Nuclease mechanisms in acute kidney injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NEPH-N (01)]


ORG_CITY: AUGUSTA

ORG_NAME: CHARLIE NORWOOD VA MEDICAL CENTER

PHR: Post-Traumatic Stress Disorder (PTSD) has caused great suffering for Veterans from loss of productivity and quality of life. It has also placed a significant and increasing financial burden on VHA in disability payments. Considering that PTSD is resistant to treatment, identifying susceptibility factors for PTSD that can be altered to increase resilience, has great potential to both decrease PTSD-associated VA costs as well as decrease loss- of-productivity and increase quality of life for many Veterans. There are sex-differences in susceptibility factors for PTSD. With the increase in female Veterans, it is important to investigate these differences so that strategies to build resilience in each sex can be developed. This grant builds upon findings from an animal model, developed by the PI, to investigate sex-differences in susceptibility factors. We will also investigate resilience building treatments in both sexes.

PI_NAMEs: VAZDARJANOVA, ALMIRA  (contact)

PROJECT_TERMS: Acoustics;Address;Affect;Amygdaloid structure;Animal Model;Anxiety;Attention;Behavior;Behavior Therapy;Behavioral;Behavioral Paradigm;behavioral phenotyping;Cognitive;cost;Coupled;cytokine;Data;Dependence;design;disability;disability payment;effective intervention;emotional experience;experience;Exposure to;Extinction;Felis catus;Female;Financial Hardship;flexibility;Fright;Functional disorder;Funding;Future;Goals;Grant;Hair;heuristics;Hippocampus;Human;Immediate-Early Genes;Impairment;improved;Incidence;Individual;Inflammatory;Injury;Interleukin-6;Intervention;Investigation;Knowledge;Maintenance;male;Medial;men;Methods;Military Personnel;military veteran;Modeling;Molecular;Muscimol;Nature;Outcome;Pathogenesis;Persons;Phenotype;post-trauma;Post-Traumatic Stress Disorders;Predisposition;Prefrontal Cortex;preservation;Prevalence;prevent;Probability;productivity loss;promote resilience;Quality of life;Rattus;Recovery of Function;Research;resilience;Resistance;sex;Sex Differences;sexual dimorphism;Societies;Soldier;Startle Reaction;statistics;stressor;Symptoms;Testing;tool;Trauma;traumatic event;United States Department of Veterans Affairs;Veterans;Woman;Women's prevalence;Work;wound

PROJECT_TITLE: Sex differences in susceptibility to a PTSD-like phenotype

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 MHBA-U (01)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DENVER

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF DENVER (COLORADO SEMINARY)

PHR: Lewy Body Dementia (LBD), a neurological disorder, is potentiated by the aggregation of a neuronal protein, α-Synuclein (αS). We have identified a ligand to rescue LBD phenotypes by reducing αS aggregation. We propose to test and optimize the pharmaceutical and efficacy of our ligand to rescue LBD phenotypes in in vivo models.

PI_NAMEs: KUMAR, SUNIL  (contact)

PROGRAM_OFFICER_NAME: CONRAD, CHRISTOPHER GARNER

PROJECT_TERMS: Affect;Affinity;alpha helix;alpha synuclein;American;analog;Animal Model;antagonist;Area;Behavioral;Binding;Binding Proteins;Biological Markers;Biological Models;blood-brain barrier crossing;Brain;brain tissue;Caenorhabditis elegans;Cells;Chemical Structure;Chemicals;Clinical Trials;Cognitive;Cognitive deficits;Complex;cytotoxicity;Dementia;design;disease model;dopaminergic neuron;Dose;Drug Kinetics;Enzymes;Event;follow-up;Future;health assessment;Human;Immunohistochemistry;Impaired cognition;Impairment;improved;In Vitro;in vitro Model;in vivo;in vivo evaluation;in vivo Model;Lead;Lewy Body Dementia;Libraries;Ligands;Location;Metabolic;meter;Microglia;mimetics;Modeling;monomer;Motor;motor deficit;motor impairment;mouse model;Mus;nanomolar;Nervous System Disorder;neuron loss;Neurons;neurotoxic;novel;Pathogenicity;Pathologic;Pathology;Permeability;Persons;Pharmacologic Substance;Pharmacology;Phase;Phenotype;Physiological;Plasma;Plasma Proteins;prion-like;Process;programs;Property;protein aggregation;Proteins;Research;RTN4 gene;scaffold;Side;Source;Surface;synthetic protein;Testing;Therapeutic;Therapeutic Intervention;Time;Toxic effect;Toxicology;Work

PROJECT_TITLE: Synthetic protein mimetics as potential therapeutics for Lewy Body Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-M (19)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Childhood ADHD is one of the most common neurodevelopmental disorders with prevalence of 5-10% across the world, and is characterized by pervasive deficits in cognitive control and motivation. This project seeks to uncover on the latent state dynamics in the cognitive control and reward systems in ADHD and particularly their evolution from resting to cognitively demanding task states. The proposed research will enhance our understanding of ADHD’s brain mechanisms using novel cognitive, neuroscience and computational models and will contribute foundational knowledge that eventually facilitate more effective and precise interventions of the disorder.

PI_NAMEs: CAI, WEIDONG  (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Address;Adolescent;Affect;associated symptom;Attention deficit hyperactivity disorder;attentional control;autism spectrum disorder;Behavioral;Brain;Brain imaging;brain research;Child;Childhood;Clinical;Cognitive;cognitive control;Cognitive deficits;cognitive neuroscience;cognitive process;Collaborations;Communities;Computational Science;computer framework;Computer Models;Computing Methodologies;Data Set;Development;Diagnosis;Disease;Economic Burden;Evolution;Family;Functional disorder;Funding;Future;Goals;Hyperactivity;Impulsivity;inattention;Individual;insight;Intervention;Investigation;Japan;Knowledge;Link;Medicine;Mental disorders;Modeling;Modernization;Motivation;multidisciplinary;Neurobiology;Neurocognitive;Neurodevelopmental Disorder;Neurology;neuromechanism;Neurosciences;novel;Nucleus Accumbens;parent grant;Parents;potential biomarker;Prevalence;Problem behavior;programs;Psychiatrist;Psychiatry;Psychology;Reproducibility;Research;Rest;reward circuitry;Rewards;Ritalin;Schizophrenia;Social Functioning;Space Models;statistics;Symptoms;System;Testing;Theoretical model;theories;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: An integrative framework of cognitive control and reward modulation in children with ADHD: from brain dynamics to clinical symptoms

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lyme Disease;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: HAYWARD

ORG_NAME: PLANET BIOTECHNOLOGY, INC.

PHR: Lyme disease (LD), caused by multiple species of the spirochete Borrelia burgdorferi sensu lato, and Relapsing Fever (RF), caused by B. miyamotoi and B. hermsii are the most common tick- borne diseases in the United States. Though acute illness is commonly treated by antibiotics, prolonged disease manifestations costs the U.S. health care system close to $4.8 billion a year. We are developing a pre-exposure prophylaxis to prevent LD and RF in individuals who are at particularly high risk of infection.

PI_NAMEs: WYCOFF, KEITH  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Acute;Adoption;Affinity;Animals;Antibiotics;Antibodies;Area;assay development;Bacteria;bacterial resistance;Binding;Biological Assay;Biological Availability;Biotechnology;Borrelia;Borrelia afzelii;Borrelia burgdorferi;Borrelia burgdorferi Group;Borrelia garinii;Borrelia Infections;Borrelia miyamotoi;Clinical Trials;Complement;Complement Factor H;cost;cross reactivity;design;Development;Diagnosis;Disease;disorder prevention;Dose;drug development;Drug Kinetics;Endothelial Cells;Europe;Exposure to;Fatigue;FDA approved;Formulation;functional improvement;Goals;Half-Life;Health;Healthcare Systems;Heparin;high risk;Human;human tissue;IgG3;Immune;Immune response;Immune system;Immunocompromised Host;Immunologic Stimulation;Impaired cognition;improved;In Vitro;in vivo;Incidence;Individual;Infection;infection risk;Injections;long-term sequelae;Longevity;Lyme Disease;Lyme Disease Vaccines;Macaca mulatta;Marketing;Medical Care Costs;Methods;Modeling;Monkeys;Monoclonal Antibodies;mouse model;Mus;Mutation;neonatal Fc receptor;New York;novel therapeutics;Oral;Order Spirochaetales;Pain;Passive Immunity;pathogen;Patients;Persons;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;Planets;Plants;Post Treatment Lyme Disease Syndrome;pre-exposure prophylaxis;Preclinical Testing;predictive modeling;prevent;Prevention;Prevention strategy;Process;prophylactic;Prophylactic treatment;protein function;Proteins;Qualifying;Quality of life;Rattus;Recombinant Proteins;Recombinants;recruit;Relapsing Fever;relapsing fever borrelia;Research;research clinical testing;Risk;Safety;Seasons;Small Business Technology Transfer Research;Surface;Sushi Domain;Symptoms;System;Testing;tick-borne;Tick-Borne Diseases;tick-borne pathogen;Ticks;Tissues;Transgenic Mice;transmission blocking;transmission process;United States;Vaccines;Variant

PROJECT_TITLE: Developing a Potent Broad-Spectrum Prophylactic for Tickborne Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-X (14)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE OF THE FUNDED PARENT AWARD Acetaminophen (APAP) exposures are ubiquitous use during pregnancy and early life during lung development. Alarmingly, clinical data support the hypothesis that the developing lung may be adversely affected by APAP exposure due to the developmental ontogeny of pulmonary CYP2E1 expression. These pre-clinical studies will be the first to interrogate the mechanisms underlying the unique susceptibility of the developing lung to APAP exposure and help determine its safety profile in this understudied population.

PI_NAMEs: WRIGHT, CLYDE JASON (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Acetaminophen;Acute;Adult;Adverse effects;Affect;Alveolar;Analgesics;Attenuated;Biology;Bronchopulmonary Dysplasia;Cell Death;cell type;Cells;Childhood;Clinical;Clinical Data;clinically relevant;CYP2E1 gene;Data;Development;drug action;Enzymes;experimental study;Exposure to;fetal;Fetal Lung;Funding;Funding Opportunities;gain of function;genetic approach;Growth;Health;Hepatic;hepatocellular injury;Hepatocyte;Hepatotoxicity;Human Development;Hyperoxia;Imines;immune activation;Immune signaling;Immunology;improved;in utero;in vivo;Injury;Knowledge;Life;Link;Liver;loss of function;Lung;lung development;lung injury;maternal safety;Mediating;medication safety;Metabolic stress;Metabolism;Mitochondria;Mitochondrial DNA;Mus;Myofibroblast;Neonatal;neonatal exposure;Neonatal Intensive Care Units;Neonatal lung;neonatal lung injury;Newborn Infant;novel;opioid exposure;Outcome;Oxidative Stress;para-benzoquinone;parent grant;parent project;Patent Ductus Arteriosus;Pathway interactions;Perception;Perinatal;Perinatal Exposure;pharmacologic;Physiology;Placenta;Population;Positioning Attribute;postnatal;pre-clinical;preclinical development;preclinical study;Predisposition;Pregnancy;pregnant;prenatal;preterm newborn;receptor;Reporting;Research;respiratory morbidity;response;Risk;Safety;Signal Transduction;Slice;Stress;stressor;Structural defect;Structure;Testing;therapeutic target;Toxic effect;Toxin;Xenobiotics

PROJECT_TITLE: Research Supplement to Promote Diversity in Health Related Research: Pulmonary implications ofperinatal acetaminophen exposure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Neurosciences;Stroke

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Artificial hibernation has the promise to impact broad medical domains, including enhancing survival rates during critical health events such as stroke and heart attacks, inhibiting the proliferation of cancer cells, extending the viability of organs for transplantation, promoting longevity, and facilitating long-distance space travel. This application will pioneer an innovative approach for inducing artificial hibernation through ultrasound neuromodulation, with the ultimate aspiration of applying this technology to medicine.

PI_NAMEs: CHEN, HONG  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Animals;aspirate;Behavior;Biological Assay;Body Temperature;Brain;cancer cell;clinical translation;Complex;Critical Pathways;disease model;Engineering;Evaluation;Event;fictional works;Food deprivation (experimental);Functional Imaging;Goals;Health;Hibernation;high reward;high risk;Human;Hypothalamic structure;induced hypothermia;innovation;interdisciplinary approach;Ion Channel;Longevity;Mammals;Medical;Medicine;Metabolic;Metabolism;Molecular;Molecular Biology;Mus;Myocardial Infarction;Nervous System;neural circuit;Neural Pathways;Neurons;neuroregulation;Neurosciences;nonhuman primate;Organ Transplantation;Organ Viability;Physiological;Physiology;programs;Proliferating;Rattus;Regulation;Research;Role;Science;space travel;Stroke;stroke model;stroke therapy;Survival Rate;System;Techniques;Technology;Therapeutic;trait;ultrasound

PROJECT_TITLE: Ultrasound-induced artificial hibernation: Mimicking natural hibernation to enhance human health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-J (70)]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Nanotechnology;Neurosciences;Stroke

ORG_NAME: UNANDUP, LLC

PHR: There are more than 700,000 annual acute ischemic stroke (AIS) events in the US which result in nearly 150,000 deaths, making AIS the fifth leading cause of death and the leading cause of neurological disability. Although thrombectomy is the standard of care for those diagnosed with a treatable large vessel occlusion in the anterior circulation, improvements in thrombolysis are needed given that most AIS events are not amenable to thrombectomy. UNandUP (short for “Unmet Needs and Underserved Populations”) has invented a safe and effective nanoparticle-based magnetic thrombolysis platform which can be applied to nearly all AIS victims.

PI_NAMEs: CREIGHTON, FRANCIS MILTON (contact);DERDEYN, COLIN PIETER

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: Acceleration;Acute;Alteplase;American;Anterior;Biological;Blood coagulation;Caring;Cause of Death;Cessation of life;Circulation;Coagulation Process;cost;Cyclic GMP;Cytolysis;Diagnosis;Diffusion;disability;Dose;Economic Burden;efficacy study;Eligibility Determination;Ensure;FDA approved;Goals;hemodynamics;Hemorrhage;Hospitals;Hour;improved;invention;Ischemic Stroke;Knowledge;Location;Magnetic nanoparticles;Magnetism;Mechanics;meetings;nanoparticle;Neurological disability;novel;Palliative Care;Pathway interactions;Pharmacologic Substance;portability;prevent;Process;Risk;Safety;safety study;standard of care;Stroke;stroke event;stroke outcome;stroke therapy;stroke victims;success;Surface;System;Thrombectomy;thrombolysis;tool;Underserved Population;United States

PROJECT_TITLE: Low-Dose Magneto-Thrombolysis to Expand Stroke Care


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Microbiome;Neurodegenerative;Neurosciences;Parkinson's Disease;Sleep Research

ORG_CITY: ALBUQUERQUE

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PHR: PROJECT NARRATIVE The proposed administrative supplement will facilitate the sharing of biospecimens with The Biospecimen Exchange for Neurological Disorders (BioSEND) repository, funded by the National Institute of Neurological Disorders and Stroke (NINDS).

PI_NAMEs: RYMAN, SEPHIRA  (contact)

PROGRAM_OFFICER_NAME: JETT, DAVID ALAN

PROJECT_TERMS: Address;Administrative Supplement;Age;Aging;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Award;Biological Markers;Biological Specimen Banks;biomarker development;Blood;Blood specimen;Brain;brain dysfunction;Breath Tests;Catalogs;Clinic;Clinical;cohort;Cohort Studies;Collection;Communities;Data Collection;data repository;Dementia with Lewy Bodies;Disease;dysbiosis;Early Diagnosis;effective therapy;Enrollment;Evaluation;Feces;Functional disorder;Functional impairment;Funding;Goals;gut microbiome;Health Sciences;Hydrogen Sulfide;Impaired cognition;Intestinal permeability;Lactulose;Leaky Gut;Lewy Body Dementia;Lewy Body Disease;Lipopolysaccharides;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Manuals;Measurement;Memory;Midbrain structure;Monitor;Movement Disorders;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neuron loss;New Mexico;novel;Outcome;Parkinson Disease;Parkinson's Dementia;Participant;participant enrollment;Patients;Phenotype;Plasma;Procedures;Process;recruit;REM Sleep Behavior Disorder;Reporting;repository;Research;Research Personnel;Rhamnose;rRNA Genes;sample collection;Sampling;sex;Site;Sleep;Specimen;stool sample;Stroke;sulfate reducing bacteria;symposium;Testing;Universities;Urine;Whole Blood

PROJECT_TITLE: Microbiome-gut-brain dysfunction in prodromal and symptomatic Lewy body diseases


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Project Narrative Low medication adherence when initiating antiretroviral treatment (ART) is a key barrier to HIV virologic suppression, resulting in avoidable cases of drug resistance, death, and viral transmission. Routinized pill-taking can lead to successful long-term ART adherence, and short-term behavioral economics-based supports are a novel way to overcome the limited success of existing routinization interventions. This study proposes to test this combined approach for promoting long-term ART adherence using a Stage III Sequential, Multiple Assignment, Randomized Trial (SMART) design in one of the largest HIV clinics in Uganda to identify the most cost-effective adaptive intervention that if found effective is generalizable to other settings and other chronic diseases.

PI_NAMEs: LINNEMAYR, SEBASTIAN  (contact);STECHER, CHAD DANIEL

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;adaptive intervention;Address;Adherence;antiretroviral therapy;Area;Behavior;behavior change;Behavior Therapy;behavioral economics;Behavioral Mechanisms;Cessation of life;Chronic;Chronic Disease;Client;Clinic;Clinic Visits;Cognitive;combat;compliance behavior;Control Groups;cost;cost effective;Cost Effectiveness Analysis;cost-effectiveness evaluation;Cues;design;Drug resistance;Economics;Evidence based intervention;Goals;Health Care Costs;Heterogeneity;HIV;implementation research;improved;Incentives;Information Dissemination;insight;Intervention;intervention effect;Maintenance;medication compliance;medication nonadherence;Motivation;novel;novel strategies;Outcome;Participant;Persons;Phase;pill;Pilot Projects;post intervention;primary outcome;Prize;Process;Publishing;Research;research study;Resource-limited setting;Resources;responders and non-responders;response;Science;secondary outcome;Self Management;Sequential Multiple Assignment Randomized Trial;success;Testing;Text Messaging;therapy adherence;Time;treatment group;treatment response;trial design;Uganda;United States National Institutes of Health;Viral;viral transmission;Work

PROJECT_TITLE: INcentives and ReMINDers to Improve Long-term Medication Adherence (INMIND)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE Based on our extensive preliminary data we now believe we have determined the degradation event that may underlie nuclear pore injury loss that occurs early in the pathogenesis of ALS/FTD. Our preliminary experiments suggest that this novel disease pathway can be pharmacologically manipulated. Thus, candidate ASO therapy could be useful for C9orf72 ALS/FTD patients and therapeutic targeting of nucleoporin and nuclear pore complex degradation and CHMP7 has potential to extend far beyond C9orf72 mediated disease.

PI_NAMEs: LUSK, CHARLES PATRICK;ROTHSTEIN, JEFFREY D (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Accounting;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Autopsy;C9ORF72;Cell Line;Clinical;Data;Defect;Degradation Pathway;Dementia;Disease;Disease Pathway;Event;Excision;experimental study;familial amyotrophic lateral sclerosis;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;Homeostasis;human tissue;Huntington Disease;Impairment;Individual;individual patient;induced pluripotent stem cell;Injury;knock-down;Link;Mammalian Cell;Mediating;Membrane;Molecular;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;Nuclear;Nuclear Envelope;Nuclear Export;Nuclear Pore;Nuclear Pore Complex;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Nucleoplasm;Pathogenesis;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Peptides;pharmacologic;Proteins;Quality Control;RNA;RNA metabolism;Spinal;sporadic amyotrophic lateral sclerosis;stressor;therapeutic target;Work;Yeasts

PROJECT_TITLE: Nuclear pore complex quality control in ALS/FTD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(03)-S]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Climate-Related Exposures and Conditions;Clinical Research;Pediatric;Social Determinants of Health

ORG_CITY: Brentwood

ORG_NAME: MYRIAD SENSORS, INC.

ORG_STATE: TN

PHR: Project Narrative Extreme heat is the leading cause of weather-related deaths in the United States (more than hurricanes and tornadoes combined), and the heat island effect intensifies these health risks, often in low-resource urban areas. Through the Heat Viz project, we can connect human health, environmental justice, and STEM education to prepare students to better address the public health risks of urban heat islands.

PI_NAMEs: ROOZEBOOM, CLIFTON LEE (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Address;Benchmarking;Biology;Cessation of life;citizen science;Climate;Collaborations;Communities;Community Outreach;Computer software;cost;Country;dashboard;Data;Data Analyses;Development;digital media;digital platform;Earth science;Education and Outreach;Educational Curriculum;Engineering;environmental justice;experience;extreme heat;Goals;Health;heat island;high school;Human;Hurricane;improved;Inequity;Instruction;interest;International;Investigation;Knowledge;Learning;learning community;Maps;Marketing;Measurement;Measures;mobile application;Outcome;Phase;Pilot Projects;Planet Earth;programs;prototype;Public Health;Randomized, Controlled Trials;Research;Resources;Risk;Schools;Science;science teacher;Science, Technology, Engineering and Mathematics Education;sensor;Small Business Innovation Research Grant;STEM student;Students;System;teacher;Temperature;Testing;Time;tool;Tornadoes;United States;university student;urban area;usability;Visualization;Weather;Work

PROJECT_TITLE: Heat Viz: An interactive digital platform for heat island investigations for K-12 STEM students


ADMINISTERING_IC: CA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: SANTA BARBARA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Cellular immunotherapies are revolutionizing cancer treatment but suffer from serious limitations. Drawing inspiration from a surprising discovery we made working on fruit flies, we propose to revolutionize and democratize an emerging cellular immunotherapy called CAR-M. We further propose to generalize the approach to remove any unwanted cell or substance from the body – from cancer to drug resistant microbes to amyloid plaques.

PI_NAMEs: MONTELL, DENISE J. (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Antigen Targeting;Autoimmune;Autoimmune Diseases;Bacterial Infections;Breast;Breathing;cancer cell;cancer drug resistance;cancer immunotherapy;Cancer Patient;cancer therapy;Cell Therapy;Cells;Cellular biology;Cellular immunotherapy;chimeric antigen receptor T cells;Colon;Complex;Consumption;cost;cytokine release syndrome;Democracy;Developmental Biology;Disease;Drosophila genus;drug resistant microorganism;Engineering;Exclusion;exhaust;Glioblastoma;Human;improved;Lung;Macrophage;Malignant Neoplasms;Multiple Bacterial Drug Resistance;Mus;Mycoses;neoplastic cell;Normal tissue morphology;Ovarian;Pancreas;Phase I Clinical Trials;Production;Reaction;Senile Plaques;Solid Neoplasm;T-Lymphocyte;Testing;Time;tumor microenvironment;Virus Diseases

PROJECT_TITLE: RaceCAR-M immunotherapy for cancer and beyond


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative The proposed study will conduct a cluster-randomized trial to establish the efficacy of an App-based video intervention to integrate U=U (Undetectable equals Untransmittable) messaging into HIV counseling in South Africa. Although treatment-as-prevention is the primary rationale for “test-and-treat” policies, the prevention benefits of antiretroviral therapy have not featured prominently in HIV counseling and public health messaging. The intervention provides accurate, up-to-date information on the science of U=U – including its limitations – alongside the U=U narratives of PLHIV, their partners, and health care workers.

PI_NAMEs: BOR, JACOB  (contact);ONOYA, DORINA

PROJECT_TERMS: Address;Adherence;Africa South of the Sahara;antiretroviral therapy;Anxiety;Attitude;Behavioral;Belief;Boston;Caring;civil society;Clinic;Clinical;Cluster randomized trial;cohort;Collaborations;Communication;Consensus;Counseling;Country;Couples;Data;data de-identification;design;Diagnosis;Education;efficacy trial;Enrollment;Epidemic;epidemiology study;Ethics;Evaluation;experience;Fright;Funding;General Population;Grant;Guidelines;Health;health economics;Health Personnel;HIV;HIV diagnosis;Human immunodeficiency virus test;improved;innovation;Institution;internalized stigma;Intervention;Interview;Knowledge;Laboratories;Link;literacy;Mental Health;Motivation;novel strategies;Outcome;Patients;Pattern;Perception;Personal Satisfaction;Persons;Policies;Pregnancy;Prevention;primary outcome;Professional counselor;prospective;Protocols documentation;Provider;Province;Public Health;Quality of life;Randomized;Recruitment Activity;Research;Research Project Grants;Resources;Risk;rural South Africa;Sampling;satisfaction;Science;Self Perception;Services;sexual relationship;sexually transmitted virus;Shapes;skills;Social Network;social stigma;South Africa;South African;support tools;Surveys;Survivors;Testing;theories;therapy adherence;therapy design;tool;Training;transmission process;treatment as prevention;unintended pregnancy;United States National Institutes of Health;Universities;uptake;Viral;Viral Load result;viral transmission;visit adherence;web platform;young adult

PROJECT_TITLE: Integrating U=U into HIV counseling: a cluster-randomized efficacy trial (INTUIT 2.0)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-A (03)]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative HIV disproportionately impacts young Black women in the Southern US. A future HIV vaccine could decrease disparities, but successful rollout will require communication that is strategic and tailored. We will use Community Engagement Studios to engage young Black women in developing communication strategies and content for increase uptake of a future HIV vaccine, within the larger family of HIV prevention tools. We will then test these communication strategies in three separate randomized trials to see what types of strategies have the great impact on HIV vaccine and prevention intention.

PI_NAMEs: DANG, BICH NGOC (contact)

PROJECT_TERMS: Address;Adoption;Affect;Age;AIDS prevention;Area;Attitude;Awareness;Basic Behavioral Science;Basic Science;Behavioral;Behavioral Sciences;Belief;Black race;black women;Characteristics;Communication;Communication Research;Communities;community based participatory research;community engagement;COVID-19 vaccine;Data;design;Development;Discrimination;Disparity;disparity reduction;distrust;Epidemic;Faculty;Family;Female;Future;Gender;Generations;health communication;Historically Black Colleges and Universities;HIV;HIV Infections;HIV vaccine;Image;Implant;Infusion procedures;Injectable;innovation;Intention;interest;Intervention;Interview;Knowledge;Lived experience;Marketing;Medical;Misinformation;Modeling;National Institute of Mental Health;neutralizing antibody;outreach;peer;Population;pre-exposure prophylaxis;Prevention;Prevention strategy;Protective Agents;Provider;randomized trial;Readiness;Recommendation;Research;Research Methodology;Research Personnel;restoration;risk perception;scale up;Science;Scientist;social factors;Social Network;social stigma;Stereotyping;Structure;Study models;Testing;Texas;theories;Time;tool;Translating;United States;Universities;uptake;vaccine acceptance;vaccine efficacy;vaccine trial;Vaccines;Woman;Work;young adult;young woman

PROJECT_TITLE: Engaging communities to develop and evaluate communication strategies for HIV vaccine and prevention uptake among Black women in the Southern US


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE HIV requires lifelong antiviral treatment because it persists within a population of silently infected cells termed the HIV reservoir. If treatment is permanently stopped, HIV reemerges and escapes from the immune system leading to AIDS. In this proposal, we will test a strategy to limit formation of the HIV reservoir by targeting proliferation of silently infected cells during the first month of infection.

PI_NAMEs: MUDD, JOSEPH CHRISTOPHER;SCHIFFER, JOSHUA TISDELL (contact);SPIVAK, ADAM MITCHELL

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Animal Model;Animals;Antigens;antiproliferative agents;antiretroviral therapy;Autologous;Binding;Blood specimen;CD28 gene;CD3 Antigens;CD4 Positive T Lymphocytes;Cell Culture Techniques;Cell Proliferation;Cells;chemotherapeutic agent;Clonality;Clone Cells;Combined Modality Therapy;Coupled;Dasatinib;Data;Deuterium;Deuterium Oxide;DNA;Dose;Drug Combinations;Drug Screening;Early Intervention;FDA approved;Generations;Half-Life;HIV;HIV Infections;HIV-1;Human;IL7 gene;Immune response;Immune system;Immunologic Memory;immunoregulation;Immunosuppression;in vitro testing;in vivo;in vivo evaluation;Individual;Infection;integration site;Interruption;kinase inhibitor;Label;leukemia;Libraries;Lymphocyte;Lymphopenia;Macaca;Macaca mulatta;mathematical model;Measures;Modeling;Molecular;Monitor;mycophenolate mofetil;Organ;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;pharmacodynamic model;pharmacokinetic model;pharmacokinetics and pharmacodynamics;pharmacologic;Plasma;Play;Population;pre-clinical;Primary Infection;Proliferating;Proviruses;Recovery;Regimen;Reporting;response;Role;Safety;Serum;SIV;Source;Structure;T-Cell Depletion;T-Cell Proliferation;T-Lymphocyte Subsets;targeted agent;Testing;Therapeutic;Therapeutic Effect;Thymidine Kinase;Time;Tissues;Toxic effect;Viral;Viral Proteins;viral rebound;Virus;Virus Diseases;Water

PROJECT_TITLE: Early intervention with anti-proliferative therapy close to ART initiation to limit long-term SIV persistence

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: In previous years the total cost of care for Veterans with psychoses has consumed 16% of the Veterans Health Administration (VHA) Veterans Equitable Resource Allocation (VERA) funds. The current investigation is intended to reveal the importance of brain waves – or oscillations - to abnormal visual perceptual experiences and symptoms of psychosis such as hallucinations and illusions. The value of the work is that oscillatory abnormalities can serve as targets for brain interventions that reduce perceptual dysfunction and psychotic symptomatology. Through state-of-the-art analysis of brain electrical activity in people with schizophrenia, this study will test whether the speed of a dominant brain oscillation (i.e., the alpha rhythm) accounts for difficulties in adapting to visual input and accurately seeing objects in one’s environment. The work includes a manipulation of the rhythm to determine if perception can be improved. Alpha manipulation will be personalized and inform neuromodulatory treatment focused on the speed of a Veteran’s alpha rhythm.

PI_NAMEs: SPONHEIM, SCOTT R (contact)

PROJECT_TERMS: Alpha Rhythm;Award;behavior measurement;Binocular rivalry;Brain;brain electrical activity;Brain region;care costs;Characteristics;Clinical;Cognition;Consumption;Data;deviant;Disease;Electroencephalography;Environment;Equity;Exhibits;experience;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Funding;future implementation;Hallucinations;High Frequency Oscillation;Illusions;Image;Impaired cognition;Impairment;improved;Individual;Intervention;Investigation;Magnetism;Measures;Mediating;neural;Neurophysiology - biologic function;neuroregulation;Occipital lobe;Perception;Perceptual distortions;Perceptual disturbance;Performance;Persons;Photic Stimulation;precision neuromodulation;Process;Psychopathology;Psychoses;psychotic;Psychotic Disorders;Research;Research Personnel;Resource Allocation;response;Rest;Role;Sampling;Schizophrenia;Severities;Speed;Stimulus;symptomatology;Symptoms;Task Performances;Techniques;Testing;Thalamic structure;Time;time use;treatment optimization;treatment response;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Visual;visual information;Visual Perception;visual processing;visual stimulus;Waxes;Work

PROJECT_TITLE: Deviant Synchronization of Neural Functions in Schizophrenia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 MHBC-F (01)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cachexia;Depression;Endometriosis;Infectious Diseases;Mental Health;Neurosciences;Women's Health Research

PHR: NARRATIVE Many non-brain disorders accompanied by acute or chronic systemic inflammation result in common behavioral symptoms like extreme fatigue and diminished motivation. The neuro-immune mechanisms and specific brain circuits mediating these convergent symptoms remain unidentified. Here, we will employ high-resolution brain-wide scans along with advanced neuroscience techniques, investigating five mouse models of systemic inflammation, aiming to pinpoint central circuits connecting inflammation to these behavioral symptoms.

PI_NAMEs: KEPECS, ADAM  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Acute;acute infection;American;Behavior;Behavioral;behavioral response;Behavioral Symptoms;Brain;Brain region;Cachexia;Cancer Cachexia;cardiac cachexia;cell type;Central Nervous System;Chronic;Code;common symptom;Communication;coping;Coupled;cytokine;Disease;Dissection;endometriosis;Fatigue;fighting;flu;Immune;immune function;Immunology;Infection;Inflammation;Inflammatory;insight;Investigation;Maps;Mediating;Mental Depression;Mental Fatigue;Moods;Motivation;mouse model;neural circuit;Neuroimmunomodulation;Neurosciences;new therapeutic target;novel;Phenotype;psychological symptom;Research;Resolution;Rest;Scanning;sensory neuroscience;sensory system;Symptoms;systemic inflammatory response;Techniques;tool;treatment strategy

PROJECT_TITLE: The cytokine code and neural circuits for sensing inflammation state


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Urologic Diseases

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Testicular germ cell tumor (TGCT) is the most common cancer in men aged 15-45. We have identified genetic changes that predispose to TGCT, and this proposal seeks to identify the mechanisms of these genetic changes by defining their impact on developing human fetal germ cells and gonad. We will use both cell models and study of individuals with atypical gonads to better understand the influence of TGCT-predisposing genes, with the goal that results from this study will provide rationale for future precision cancer prevention and treatment strategies.

PI_NAMEs: PYLE, LOUISE CLARE (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Adult;aged;Alleles;ambiguous genitalia;Anxiety;ATAC-seq;Atypia;Award;Basic Science;biobank;Bioinformatics;Biological Process;Cancer Biology;Cancer Remission;Cardiovascular Diseases;career;causal variant;Cell model;Cells;CHEK2 gene;Child;Childhood;Chromatin;Clinical;Complex;Congenital Abnormality;conventional therapy;Copy Number Polymorphism;CRISPR/Cas technology;Cryptorchidism;Data;Data Set;design;Development;Diagnosis;Doctor of Philosophy;Electronic Health Record;epidemiology study;Epigenetic Process;exome sequencing;Family;fetal;Fetal Development;Five-Year Plans;Funding;Future;GAB2 gene;Gene Expression;Genes;Genetic;genetic approach;Genetic Predisposition to Disease;Genitalia;Genome;genome wide association study;genomic data;genomic variation;Genomics;Genotype;Germ cell tumor;Germ Cells;Germ Lines;Goals;gonad development;Gonadal Disorders;Gonadal structure;Heritability;Human;Human Genetics;human model;human tissue;Hypogonadism;Hypospadias;Impairment;improved;Individual;induced pluripotent stem cell;induced pluripotent stem cell technology;innovation;International;Knock-out;Knowledge;lifetime risk;Malignant Neoplasms;medical specialties;men;Mental Depression;Mentors;Mentorship;Modeling;Molecular Biology;Molecular Epidemiology;Morbidity - disease rate;Mutation;Oncology;Pathway interactions;Pediatric Hospitals;Pennsylvania;phenotypic data;Philadelphia;Physicians;Population Study;precision cancer prevention;precision genetics;precision medicine;Predisposition;Prevention;Prevention strategy;Qualifying;recruit;Regulation;Research;Research Personnel;Research Project Grants;Resources;Risk;risk variant;Role;Scientist;Signal Transduction;skills;Specific qualifier value;stem cell biology;Structure of primordial sex cell;Susceptibility Gene;Testicular Germ Cell Tumor;Testing;tool;Training;transcriptome sequencing;Translational Research;treatment strategy;tumor;Universities;Work;years of life lost

PROJECT_TITLE: Mechanisms and Fetal Origins Underlying Gonadal Germ Cell Tumor-AWARDED

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE The proposed studies address the important issue of immune suppression and dysfunction of tumor-reactive T cells mediated by human regulatory T cells that is a major barrier for successful anti-tumor immunity and immunotherapy. The proposed research has relevance to public health, because it seeks to dissect a novel suppressive mechanism and then to develop critical strategies that control immune suppression mediated by human regulatory T cells. Thus, the findings are ultimately expected to be applicable to improve the treatments against human cancer and immune-related diseases as well.

PI_NAMEs: PENG, GUANGYONG  (contact)

PROJECT_TERMS: Address;Adoptive Transfer;Affect;anti-tumor immune response;ATM Signaling Pathway;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;Cell Aging;Cell Senescence Induction;Cells;Cellular Metabolic Process;Clinical Trials;CTLA4 gene;cytokine;Development;Disease;DNA Damage;effector T cell;Enzymes;exhaust;Exhibits;Functional disorder;Gene Expression Regulation;Generations;glucose metabolism;Human;Immune;immune checkpoint blockade;Immune System Diseases;Immunosuppression;Immunotherapy;improved;Inflammatory;Interruption;Investigation;lipid metabolism;Lipids;Malignant Neoplasms;MAP Kinase Gene;MAPK3 gene;Mediating;Melanoma;metabolic profile;Metabolism;Modeling;Molecular;Mus;neoplasm immunotherapy;neoplastic cell;novel;novel strategies;Outcome Study;p38 Mitogen Activated Protein Kinase;Pathway interactions;PD-1/PD-L1;Phosphorylation;prevent;Process;programs;Public Health;Regulatory T-Lymphocyte;Rejuvenation;Reproducibility;Research;response;senescence;sensor;Signal Transduction;STAT1 gene;STAT3 gene;success;T-Lymphocyte;targeted treatment;Testing;Therapeutic;TLR8 gene;transcription factor;tumor;Tumor Immunity;Tumor-Derived;Writing

PROJECT_TITLE: Targeting T Cell Senescence and Dysfunction for Anti-tumor Immunity

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ORG_CITY: PITTSBURGH

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative: Overall The goal of the UPMC Hillman Cancer Center Melanoma and Skin Cancer Program (MSCP) SPORE is to improve melanoma and skin cancer treatment through the understanding and development of novel approaches to immunotherapy in three translational research Projects, supported by three Cores, and vibrant Developmental Research and Career Enhancement Programs. The MSCP SPORE will use an interdisciplinary approach with research program leaders whose broad and complimentary basic and clinical expertise and commitment to translational research will meet these objectives.

PI_NAMEs: KIRKWOOD, JOHN MUNN;ZAROUR, HASSANE M (contact)

PROGRAM_OFFICER_NAME: KUZMIN, IGOR A

PROJECT_TERMS: Advocate;Agreement;anti-PD-1;Award;Basic Science;Bioinformatics;Biological Specimen Banks;Biometry;Cancer Biology;cancer cell;Cancer Center;Cancer Patient;cancer therapy;career;Cell Death;chemotherapeutic agent;Clinical;clinical efficacy;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Combination immunotherapy;combinatorial;Communities;Core Facility;cost effective treatment;Cutaneous;Data;data sharing;Development;Devices;efficacy evaluation;experience;Fostering;Goals;Head and Neck Cancer;immune stimulant;Immunocompetent;immunodeficiency;immunogenic cell death;immunogenicity;Immunologic Monitoring;Immunologics;immunosuppressed;Immunotherapy;immunotherapy trials;improved;improved outcome;in vivo imaging;innovation;Institution;interdisciplinary approach;Legal patent;Lung;Malignant Neoplasms;Melanoma;member;Metastatic Melanoma;Multi-Institutional Clinical Trial;Needles;Nivolumab;novel;novel strategies;organizational structure;Ovarian;Pathology;patient population;Patient-Focused Outcomes;Patients;Pharmacologic Substance;Phase;Policies;programmed cell death protein 1;programs;randomized, clinical trials;Reproducibility;Research;research and development;Research Personnel;Research Project Grants;Research Support;Resistance;Resource Sharing;Resources;response;Risk;sample collection;Science;Seminal;Serious Adverse Event;Services;Skin Cancer;skin squamous cell carcinoma;success;Sum;Talents;Testing;Time;Translating;translational cancer research;Translational Research;translational scientist;treatment and outcome;tumor immunology;United States National Institutes of Health;Universities

PROJECT_TITLE: Melanoma and Skin Cancer Program SPORE


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Substance use disorder is a multidimensional neurological disease increasing in prevalence across the United States despite increased awareness and substantial leaps in treatment approaches. Unfortunately, these treatments commonly fail due to strongly encoded drug-associations, often resulting in relapse. The experiments in this Proposal aim to identify previously unknown functional and molecular plasticity involved in drug-seeking behaviors needed to develop targeted pharmacotherapies to reduce and hopefully eliminate relapse episodes and overdoses.

PI_NAMEs: JORGENSEN, EMILY  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Action Potentials;Address;Alcohols;Animal Model;Area;Awareness;Behavior;Behavioral;behavioral plasticity;Biological Models;Brain;Brain region;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;cocaine exposure;cocaine reward;cocaine seeking;cocaine self-administration;common treatment;compulsion;Consumption;Corpus striatum structure;Cues;Data;Dimensions;Disease;Dissociation;Dopamine;Dopamine Receptor;dopamine system;DRD1 gene;DRD2 gene;drug of abuse;drug seeking behavior;Electrophysiology (science);Epilepsy;experimental study;Family member;Foundations;functional plasticity;Future;Genes;Genetic;genetic manipulation;Genetic Transcription;Glutamates;in vivo;Infusion procedures;Injections;insight;Ion Channel Gating;learned behavior;Learning;Mediating;Membrane;Memory;mesolimbic system;Molecular;Mood Disorders;motivated behavior;Nervous System Disorder;neuronal excitability;Neurons;neuropsychiatric disorder;novel;Nucleus Accumbens;Overdose;patch clamp;patch sequencing;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Physiological;Physiology;Play;Population;population based;Potassium Channel;Prefrontal Cortex;Prevalence;Property;psychostimulant;Rattus;Regimen;Relapse;Research;response;reward processing;Rewards;Role;Substance abuse problem;Substance Use Disorder;System;Testing;tool;transcriptome sequencing;transmission process;United States;Ventral Tegmental Area;voltage;Voltage-Gated Potassium Channel;Withdrawal;Work

PROJECT_TITLE: Contributions of KCNQ2/3 channels to medium spiny neuron excitability and cocaine reward


NIH_SPENDING_CATS: Cancer;Skin Cancer

PHR: Project Narrative: Administrative Core The Administrative Core provides oversight and coordination for all components of the Melanoma and Skin Cancer Program (MSCP) SPORE. The Administrative Core provides centralized administrative and fiscal functions that optimize and assure the efficiency of the proposed translational research to improve the understanding and therapy of melanoma and other skin cancers. It assures linkage of the MSCP SPORE with the Regional Melanoma Consortium, the Network Lead Academic Participating Sites and other NCI National Clinical Trials Network efforts of the institution, and the other Melanoma and Skin Cancer SPOREs.

PI_NAMEs: ZAROUR, HASSANE M (contact)

PROJECT_TERMS: Address;Advocacy;Advocate;anti-cancer research;Awareness;Budgets;Cancer Center;career;clinical translation;Clinical Trials;Collaborations;Communication;Communities;Contracts;Dedications;Dermatology;Development;Endowment;Ensure;Evaluation;Extramural Activities;Faculty;Fostering;Funding;Goals;Guidelines;Human Resources;improved;Industry;Institution;International;Lead;Malignant Neoplasms;Medical center;meetings;Melanoma;Melanoma patient;Mission;Monitor;National Clinical Trials Network;operation;outreach;Patient-Focused Outcomes;Patients;Periodicals;Pharmacologic Substance;Pilot Projects;programs;Research;Research Project Grants;Resource Allocation;Resources;Schools;Site;Skin;Skin Cancer;success;translational goal;translational progress;Translational Research;translational scientist;Universities;Vision;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Mental Illness;Pediatric;Prevention;Suicide;Suicide Prevention

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Suicide claims more than forty thousand lives in the United States each year, making it a leading cause of death, the 2nd leading cause of death for adolescents, and a devastating public health concern. The goal of this project is to test the associations between interoceptive processes and the occurrence of STBs during adolescence, using innovative, rigorous methods such as ecological momentary assessment, hospital-based data collection, and advanced statistical modeling. Results can provide an enhanced understanding of suicidal thoughts and behaviors in adolescents, which can provide crucial insight to improve understanding of suicide in adolescence, as well as novel targets for clinical intervention and suicide prevention.

PI_NAMEs: REID-RUSSELL, AZURE  (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Adolescence;Adolescent;Adult;aged;Area;Attention;bodily sensation;Cause of Death;Clinical;Data Collection;Development;directed attention;Ecological momentary assessment;Exhibits;experience;Exposure to;Feeling suicidal;Goals;high risk;high-risk adolescents;Hospitals;improved;innovation;inpatient psychiatric treatment;insight;Interoception;Intervention;Language;Learning;life span;Link;Measurement;Mediating;Mediator;Meta-Analysis;Methods;Modeling;Nature;negative affect;novel;Pathway interactions;pediatric trauma;Perception;Prevention;Process;programs;psychologic;Psychopathology;Psychophysiology;Public Health;Recording of previous events;Research;Risk;Risk Factors;Sampling;Severities;skills;Statistical Methods;Statistical Models;statistics;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Surveys;Testing;Time;Training;traumatized children;United States;Work;years of life lost

PROJECT_TITLE: Interoception as a Novel Risk Factor for Suicidal Thoughts and Behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE The PI discovered that the humoral immune response is controlled through novel and specific epigenetic mechanisms linked to histone modifying enzymes, which cause malignant transformation when perturbed through somatic mutations that are present in a majority of patients with B-cell lymphomas. In this proposal he will determine the signals that control histone modifying complexes during the normal immune response and how somatic mutations of histone modifying enzymes reprograms B-cells to undergo malignant transformation by disrupting these signals. Based on functional studies he will identify and test the efficacy of epigenetic- targeted drugs that counteract the effect of these mutations on the epigenome and sensitize lymphomas to other targeted agents and immunotherapies.

PI_NAMEs: MELNICK, ARI M. (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Affinity;B cell differentiation;B-Cell Lymphomas;B-Lymphocytes;Biological;Clinic;clinical training;Clinical Trials Design;Clonal Evolution;Complex;CREBBP gene;Drug Targeting;efficacy testing;Enzymes;EP300 gene;Epigenetic Process;epigenome;epigenomics;Equilibrium;EZH2 gene;Faculty;Failure;Follicular Lymphoma;Funding;Genetic Transcription;Genetically Engineered Mouse;Genomic Instability;HDAC3 gene;histone acetyltransferase;histone methyltransferase;Histones;Human;Immune response;Immunoglobulins;immunological synapse;Immunotherapy;inhibitor;Journals;large cell Diffuse non-Hodgkin's lymphoma;Libraries;Link;Lymphoma;Malignant - descriptor;Malignant Neoplasms;Modeling;Mus;mutant;Mutation;neoplastic cell;new technology;Normal Cell;novel;Organoids;Paper;Pathogenesis;Patients;Phenotype;Physicians;Principal Investigator;Process;programs;Proliferating;Publishing;rational design;Reaction;Reader;Research;Scientist;Signal Transduction;Somatic Mutation;Structure of germinal center of lymph node;targeted agent;Translating

PROJECT_TITLE: Targeting Epigenetic Circuits in B-Cell Lymphomas


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Skin Cancer

PHR: Project Narrative: Core 1 Biospecimen and Translational Pathology Core  Core 1 processes, analyzes and banks blood and tissue from melanoma patients in a regulated and  standardized environment to optimize and maximize what is learned from each patient’s samples.

PI_NAMEs: WHITESIDE, THERESA L. (contact)

PROJECT_TERMS: biobank;Biological;Biological Assay;Biological Response Modifier Therapy;Blood Banks;Blood Cells;Body Fluids;Cancer Center;cancer immunotherapy;Cells;Characteristics;Circulation;Clinical;Clinical Informatics;Clinical Research;Clinical Trials;Collaborations;Core Facility;Correlative Study;Data;data de-identification;data sharing;Databases;Dedications;design;digital;Enrollment;Ensure;Environment;Evaluation;Funding;Genotype;Grant;Health Insurance Portability and Accountability Act;Human body;Image;Immune response;Immunofluorescence Immunologic;Immunologic Monitoring;Immunosuppressive Agents;Immunotherapy;Laboratories;Learning;Link;liquid crystal polymer;Malignant Neoplasms;Medical center;Melanoma;Melanoma Cell;Melanoma patient;Metadata;nano-string;neoplasm registry;neoplastic cell;operation;Outcome;participant enrollment;Pathologic;Pathologist;Pathology;Patients;Peripheral;Phenotype;Process;programs;Protocols documentation;Recording of previous events;repository;Research;Research Personnel;Research Project Grants;Resources;Role;Sampling;Services;Skin Cancer;Specimen;Specimen Handling;Squamous cell carcinoma;Standardization;success;System;Therapeutic Intervention;Tissue Harvesting;Tissues;Translational Research;Triage;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;Universities;Update;Work

PROJECT_TITLE: Core 1: Biospecimen and Translational Pathology Core


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Chicago

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Mandibular fractures resulting from trauma can cause limited mobility, pain, and diminished quality of life, and these unstable fractures heal through the mobilization and differentiation of progenitor cells. This proposal will study the molecular mechanisms of healing in unstable mandibular fractures. The proposed studies will lead to a better understanding of how this healing occurs and may identify new therapeutic targets to improve patient outcomes.

PI_NAMEs: BANKS, JONATHAN MATTHEW (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Address;Alkaline Phosphatase;Animal Model;Biological Markers;Biology;bone;Bone callus;bone fracture repair;Bone Regeneration;calcification;career development;Cartilage;cartilage cell;Cell Differentiation process;cell injury;cell type;Cells;Chondrocytes;Clinical;Collagen Type VI;condylar cartilage;craniofacial;CSPG4 gene;Data;Decision Making;Degenerative polyarthritis;design;Development;Epiphysial cartilage;Exhibits;face bone structure;Fracture;Goals;healing;Immunohistochemistry;Impaired healing;Impairment;improved;In Vitro;in vivo;Incidence;Institution;Intervention;intramembranous bone formation;Joint structure of suture of skull;knockout animal;Knockout Mice;Knowledge;laboratory experiment;Ligands;Limb structure;Link;Mandible;Mandibular Fractures;MAPK3 gene;mechanical load;Mechanics;Membrane;Mentors;mineralization;Molecular;mouse model;Neck;new therapeutic target;novel therapeutics;Oral;Osteoblasts;osteochondral tissue;osteogenic;osteoprogenitor cell;Osteotomy;Outcome;Outcome Study;Pain;Pathway interactions;Patient-Focused Outcomes;Periosteum;Physiologic Ossification;Postoperative Period;pre-clinical;Proteoglycan;Quality of life;receptor;Regulation;Research;Resolution;Resources;response;response to injury;Role;Science;Scientist;Signal Transduction;Skeletal system;stem cell differentiation;stem cells;Temporomandibular Joint;Testing;Time;Tissues;Training;Transgenic Organisms;Trauma;Western Blotting;Work

PROJECT_TITLE: NG2/CSPG4 in Mandibular Endochondral Fracture Healing

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]