ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Brain Disorders;Congenital Muscular Dystrophy;Congenital Structural Anomalies;Intellectual and Developmental Disabilities (IDD);Muscular Dystrophy;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Loss of functional Dystroglycan leads to a form of congenital muscular dystrophy that is frequently accompanied by a wide range of neurological defects. This proposal will use a range of genetic models to determine how Dystroglycan controls inhibitory synapse development and function, test whether synaptic defects can be rescued, and define the functional relevance of a novel Dystroglycan interaction at synapses. These studies will provide important insights into the function of Dystroglycan in the nervous system and test a translationally-relevant treatment rationale.

PI_NAMEs: WRIGHT, KEVIN  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Adhesions;Affect;Binding;Biochemical;Biological Assay;Brain;brain abnormalities;Cell Physiology;clinically relevant;CNR1 gene;Cobblestone Lissencephaly;Coculture Techniques;Cognitive deficits;Complex;Congenital cerebellar hypoplasia;congenital muscular dystrophy;Data;Defect;Development;Dystroglycan;dystroglycanopathy;Electrophysiology (science);Etiology;Exhibits;experimental study;extracellular;Extracellular Domain;Extracellular Protein;Family;Foundations;Functional disorder;functional loss;gene therapy;Genes;Genetic;genetic approach;Genetic Models;glycosylation;hippocampal pyramidal neuron;Hippocampus;Human;Hydrocephalus;Image;imaging approach;in vivo;Inhibitory Synapse;insight;Integral Membrane Protein;Interneurons;Laminin;Ligand Binding;Maintenance;Mediating;Membrane Glycoproteins;Modeling;Molecular;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Nature;nerve supply;Nervous System;Neurologic;Neurologic Dysfunctions;Neurologic Symptoms;Neurons;novel;Patient observation;Patients;Phenocopy;Play;Polysaccharides;postsynaptic;Postsynaptic Membrane;presynaptic;Process;Proteins;Proteomics;Regulation;Retina;Role;scaffold;Seizures;Signal Transduction;Synapses;synaptic function;Synaptic Membranes;synaptogenesis;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;Transmission Electron Microscopy;white matter;Work

PROJECT_TITLE: Synaptic dysfunction in models of dystroglycanopathy


ADMINISTERING_IC: GH

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Center for Global Health

ORG_CITY: TBILISI

ORG_COUNTRY: GEORGIA

ORG_FIPS: GG

ORG_NAME: NATIONAL CENTER FOR DISEASE CONTROL

PHR: Project Narrative National Center for Disease Control and Public Health (NCDC) represents central Agency for public health in Georgia which main mission is protection and improvement of the health of Georgian population through scientific evidence-based prevention, preparedness and timely response to the public health threats. To fulfil the primary mission of protection on public health and meet the Global Health Security (GHS) Agenda which represent a shared responsibility among different partners/agencies both within and outside of the health sector, The NCDC in with collaboration with CDC and local institutions within the collaborative grant project titled “Conducting research on diseases of global and local public health importance to create scientific basis for implementation and enhancement of public health policies and practices in Georgia” (RFA-GH-20-004 Conducting Public Health Research in Georgia) is planning to implement two research projects : #1 Study of Etiology, Risk Factors and Molecular Epidemiology of Zoonotic and Vector-borne Acute Febrile Illnesses in Georgia, 2020-2025 and #2 Molecular epidemiology and associated risk- factors of multi-drug resistant pathogens, in Georgia, 2020-2025

PI_NAMEs: IMNADZE, PAATA  (contact)

PROJECT_TITLE: GH20-004 - Conducting research on diseases of global and local public health importance to create scientific basis for implementation and enhancement of public health policies and practices in Georgia


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: NARRATIVE The knowledge, reagents, and systems developed in this study are anticipated to illuminate mechanisms of KSHV transmission across epithelial barriers, and to energize investigation of strategies to inhibit both KSHV transmission and Kaposi's sarcoma. The effort is further anticipated to invigorate the development of rational KSHV prevention strategies and vaccines, and will facilitate structural biological approaches to understand the role of neutralizing antibody-KSHV interactions.

PI_NAMEs: WEST, JOHN T.;WOOD, CHARLES  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Address;Adult;Africa South of the Sahara;African;Anti-Retroviral Agents;Antibodies;Antibody Formation;Archives;B-Lymphocytes;Biological;Blood;BLT mice;Cell Separation;cell type;Cells;cervicovaginal;chronic infection;Complementary DNA;Country;Development;Disease;early childhood;Epithelium;Etiology;experience;Exposure to;Foundations;Helminths;Herpesviridae Infections;HIV Infections;HIV Seronegativity;HIV-1;Human;Human Herpesvirus 8;human model;human monoclonal antibodies;human tissue;humanized mouse;Immune response;Immunoglobulins;In Vitro;in vivo Model;Incidence;Individual;Infection;Infection prevention;Insecta;intraperitoneal;Intravenous;Investigation;Kaposi Sarcoma;Knowledge;Ligands;Malaria;Malignant Neoplasms;Modeling;mouse model;Mucous Membrane;Neoplasms;neutralizing antibody;novel;Oral;Palate Kaposi's Sarcoma;Parasitic infection;Patients;Population;Prevalence;prevent;Prevention;Prevention strategy;Process;prophylactic;protective efficacy;Reagent;Reporting;Research;Risk Factors;Role;Route;Saliva;Serum;Sexual Transmission;SIV;Source;System;Tanzania;Testing;Tissue Model;Tissues;transmission process;tumor;vaccine development;Vaccines;Vagina;vaginal mucosa;Viral;Viral Load result;virus host interaction;Zambia

PROJECT_TITLE: Models for KHSV transmission and its inhibition


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: LEXINGTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE The number of clinician scientists and, in particular, surgeon scientists is decreasing at an alarming rate; this reduction negatively impacts the ability and rapidity to “translate” basic and clinical discoveries made in cancer research to the patient. Our training program, representing a collaboration between the Markey Cancer Center and the academic clinical departments (Departments of Surgery, Pathology and Laboratory Medicine, and Otolaryngology-Head & Neck Surgery and the Division of Gynecologic Oncology) at the University of Kentucky, is focused on the interdisciplinary training of future clinician scientists in the various surgical specialties and disciplines. The overall objective of this program is to train clinician scientists in the skills and expertise in Basic Science (Track 1) and Healthcare Delivery Research (Track 2) to compete in the academic arena and to be active participants in multidisciplinary cancer teams, which are required for the care of the complex cancer patient.

PI_NAMEs: EVERS, BERNARD MARK (contact);HULL, PAMELA CARMEN;O'CONNOR, KATHLEEN L.

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TITLE: Oncology Research Training for Surgeon-Scientists

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: MD

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative Fertility is extremely important to many young women diagnosed with cancer. The deleterious effects of cancer treatments on fertility among medically underserved cancer survivors has emerged as an important area of widening disparity in health care. Study findings should reveal the mechanisms underlying disparities in access to assisted reproductive technologies (ARTs); these much-needed findings could be used by policymakers to improve access to ARTs for vulnerable populations.

PI_NAMEs: RAUH-HAIN, JOSE ALEJANDRO (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: access disparities;Address;Affect;Age;Alaska Native;American;American Indians;American Medical Association;American Society of Clinical Oncology;Area;Asian;Assisted Reproductive Technology;Biological;Birth;Birth Rate;Black race;California;cancer care;cancer diagnosis;Cancer Survivor;cancer therapy;Caring;Censuses;Childbirth;Clinic;Clinical;Colorado;Connecticut;cost;Data;Data Linkages;Desired Family Sizes;Diagnosis;Dimensions;Disparity;disparity reduction;Education;Ensure;Equity;ethnic minority;Ethnic Minority Women;Ethnic Origin;Face;Family;Fertility;fertility preservation;Financial Support;Future;Geographic Locations;Geography;Goals;health care disparity;health disparity;health equity;Hispanic;Household;Human Rights;Improve Access;improved;Income;Individual;Infertility;infertility treatment;Insurance;Insurance Carriers;Insurance Coverage;involuntary childlessness;Iowa;K-Series Research Career Programs;Kentucky;Live Birth;Louisiana;Malignant Neoplasms;Maryland;Massachusetts;Measures;Mediating;Medical;medical specialties;medically underserved;medically underserved population;Methods;Michigan;National Institute on Minority Health and Health Disparities;Neighborhoods;neoplasm registry;New Jersey;New Mexico;North Carolina;novel;oncofertility;Outcome;Patients;Policies;Policy Maker;Population;population based;Poverty;Privatization;psychologic;quality of life for cancer survivors;Race;racial minority;racial minority women;Records;Reporting;reproductive;Reproductive Health;Reproductive Medicine;Research;Resources;rural area;Services;social determinants;social disparities;Societies;Source;Specialist;success;Survivors;System;Time;Uninsured;United States;Utah;Virginia;Vulnerable Populations;Woman;women's diagnosis;Work;young woman

PROJECT_TITLE: Health equity in fertility specialty care among cancer survivors

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative Key populations including men who have sex with men (MSM) and transgender women (TGW) are at disproportionate risk for HIV, and pre-exposure prophylaxis (PrEP) has been shown effective in reducing HIV acquisition when implemented as part of a combination prevention strategy. However, suboptimal retention and adherence have adversely affected the scale-up, implementation and effectiveness of PrEP delivery. This study aims to use advanced machine learning approaches to deepen our understanding of individual-level facilitators and barriers to retention in PrEP care and effective PrEP use among MSM and TGW in Thailand, informing tailored interventions to optimize PrEP engagement for precise HIV prevention.

PI_NAMEs: JANAMNUAYSOOK, RENA ;LIU, FEIFAN  (contact);PHANUPHAK, NITTAYA

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adopted;Affect;Age;AIDS prevention;Awareness;Behavioral;Caring;Categories;Certification;Client;Clinical;clinical predictors;Communities;Complex;Country;Data;Data Sources;deep learning;deep learning model;design;Development;effective intervention;Effectiveness;Epidemic;Feedback;follow-up;Foundations;Goals;Guidelines;health disparity;high risk;High Risk Woman;HIV;HIV Infections;HIV risk;improved;Individual;Infection;innovation;innovative technologies;Intervention;Knowledge;Logic;Machine Learning;machine learning prediction;member;men who have sex with men;Modeling;Morbidity - disease rate;mortality;National Institute of Mental Health;Outcome;Pattern;peer;Performance;Persons;Play;Politics;Population;Populations at Risk;pre-exposure prophylaxis;Predictive Factor;predictive modeling;prevention effectiveness;Prevention Research;Prevention strategy;programs;protective factors;Provider;Recommendation;Reporting;Research;Research Priority;Resource-limited setting;Risk;Risk Behaviors;Risk Factors;Role;scale up;service delivery;service providers;Services;social;sociodemographics;Solid;Statistical Data Interpretation;Subgroup;System;Techniques;Thailand;therapy development;Training;transgender women;Translating;United Nations;uptake;usability;Visualization

PROJECT_TITLE: Applying Deep Learning for Predicting Retention in PrEP Care and Effective PrEP Use among Key Populations at Risk for HIV in Thailand

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ATHENS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: The Genetics Training Program provides directed training and support of a diverse cohort of pre-doctoral students who are conducting genetics research at the University of Georgia. The training program, which funds ten T32 traineeships per year, emphasizes rigorous, ethical, and inclusive training of the next generation of scientists. Students receive training in modern genetics, quantitative methods, communication, and other professional skills that will enable them to become leaders in the biomedical workforce and excel in careers in research, teaching, biotechnology, and government.

PI_NAMEs: DYER, KELLY A (contact);GOLL, MARY GRACE

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Genetic;Grant;pre-doctoral;Training

PROJECT_TITLE: T32 Predoctoral Training Grant in Genetics

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: The role of glucagon in the pathogenesis of type 2 diabetes has been relatively understudied. There is some evidence that its actions on carbohydrate metabolism are dissociated from those on amino acid, and perhaps, lipid metabolism. Understanding the reciprocal relationship between glucagon secretion and actions on these metabolites as proposed in this series of experiments will help better understand the role of glucagon in diabetes pathogenesis.

PI_NAMEs: VELLA, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acute;Adipose tissue;adult obesity;Agonist;Alpha Cell;Amino Acids;antagonist;Beta Cell;Body Weight decreased;Caloric Restriction;carbohydrate metabolism;Catabolism;Cell Physiology;Cell secretion;Data;Defect;diabetes pathogenesis;diabetes risk;Dissociation;experimental study;Fasting;fasting glucose;Fatty acid glycerol esters;fatty acid oxidation;Fatty Liver;Functional disorder;Glucagon;Glucagon Receptor;Gluconeogenesis;Glucose;glucose metabolism;glucose production;Health;Hepatic;Hepatocyte;Heterogeneity;Hormones;Human;Hydrolysis;Hyperglycemia;Impairment;improved;in vivo;Individual;Insulin;Lead;Leucine;Lipase;lipid metabolism;Lipolysis;Liver;liver metabolism;Measures;Methods;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;obese person;Obesity;Palmitates;Pathogenesis;Persons;Play;Postprandial Period;Prediabetes syndrome;protein metabolism;Proteins;Reporting;response;restoration;Review Literature;Rodent;Role;Series;Thinness;Tissues;transamination;Triglycerides;uptake;Work

PROJECT_TITLE: Glucagon secretion and action in humans


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE In this proposal, we aim to explore new mechanisms/communication routes by which skeletal muscle defects, via secreted endocrine signaling biomolecules, affect pulmonary vascular remodeling. As there are no therapies for PH-HFpEF treatment available at present, successful completion of the proposed work may provide important new insight into the mechanistic basis of PH-HFpEF pathogenesis, which may lead to the development of specific and effective treatments. The identification of circulating and muscle-specific molecular targets and their correlation with PH-HFpEF severity and/or disease progression/management may also aid in providing important information to guide future research towards facilitation of screening, diagnosis, refinement of specific patient phenotype, designing entry criteria for clinical trials in PH-HFpEF

PI_NAMEs: LAI, YEN CHUN CHARLY (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Affect;Aging;angiogenesis;biobank;Biological Markers;Biopsy;Blood Vessels;cell motility;Cell Proliferation;Clinical;clinical diagnosis;clinical risk;Clinical Trials;clinically relevant;cohort;Communication;comparison control;coronary fibrosis;Data;Deacetylase;Defect;Depressed mood;design;Development;Diagnosis;Disease Management;Disease Progression;effective therapy;EFRAC;Endocrine;Endothelium;Exhibits;Fatty acid glycerol esters;feeding;Fibroblast Growth Factor;Globulins;Grant;Heart Atrium;Heart failure;Homologous Gene;in vivo;induced pluripotent stem cell;Injury;insight;Kidney Diseases;Knockout Mice;Link;Lung;Major Histocompatibility Complex;Mass Spectrum Analysis;Mediating;Metabolic syndrome;Mitochondria;Modeling;Molecular;Molecular Target;Monitor;Mus;Muscle;Obesity;overexpression;Oxidoreductase;Pathogenesis;Pathologic;Pathology;Patients;Phase II Clinical Trials;Phenotype;Plasma;Pre-Clinical Model;preservation;pressure;Production;Prognosis;Proliferating;Property;Protein-Lysine 6-Oxidase;Proteins;Proteomics;pulmonary artery endothelial cell;Pulmonary artery structure;Pulmonary Capillary Wedge Pressure;Pulmonary Hypertension;pulmonary vascular remodeling;Rattus;Recombinant Proteins;Repression;Research;response;risk stratification;Role;Route;screening;Severities;Severity of illness;Signal Transduction;Signaling Molecule;Sirtuins;Skeletal Muscle;Smooth Muscle Myocytes;SU 5416;targeted treatment;Testing;therapeutic development;treatment response;Validation;Work

PROJECT_TITLE: Role of Skeletal Muscle in Pulmonary Vascular Remodeling

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative Alcohol use disorder is a chronic, relapsing disease that directly affects approximately 15 million people just in the United States. The cost to society and individuals related to persons suffering from alcoholism is extreme. This training program will create experts capable of carrying on meaningful research on the biological mechanisms underlying the etiology, treatment and prevention of alcohol use disorder.

PI_NAMEs: RYABININ, ANDREY E (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Alcoholism;base;Biological

PROJECT_TITLE: BIOLOGICAL BASES OF ALCOHOLISM


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Neurosciences;Substance Misuse

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: The Integrated Graduate Program in Neuroscience at the University of Texas Health Science Center at San Antonio provides training in many areas of expertise from molecular to behavioral neuroscience, in a biomedical research environment that fosters a unique exposure to clinical and translational neuroscience. We provide a program of coursework, mentored laboratory research, and professional enrichment activities tailored to the individual interests and needs of our students, with a history of successful outcomes training motivated and talented students from under-represented populations, and sustaining competitiveness on a national scale. Renewed funding of this training grant will continue the growth and development of our program, and enhance our ability to prepare our students for impactful careers as neuroscientists, ready to meet the most complex challenges and opportunities in our field.

PI_NAMEs: MORILAK, DAVID A (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurosciences;Training Programs

PROJECT_TITLE: Integrated Graduate Training Program in Neuroscience, UTHSCSA


NIH_SPENDING_CATS: Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Kidney Disease;Pediatric;Pediatric - AIDS

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Children and adolescents living with HIV (CALWH) who carry two risk alleles of a gene named APOL1 are at high risk of developing chronic kidney diseases (CKD) despite modern antiretroviral therapy (ART). However, other factors play a role in this process and the mechanisms are poorly understood. This proposal will close a critical gap in our knowledge to understand how the circulating levels of an angiogenic growth factor named FGF-2, interact with APOL1 and other HIV viral proteins to precipitate CKD in CALWH on ART.

PI_NAMEs: RAY, PATRICIO E. (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Acceleration;Affect;Affinity;Africa South of the Sahara;African ancestry;AIDS-Associated Nephropathy;antiretroviral therapy;APOL1 gene;Area;Binding;Cell Line;Cells;Child;Childhood;Chronic Kidney Failure;Circulation;Clinical;CRISPR/Cas technology;cytokine;Cytoskeleton;District of Columbia;Endothelial Cells;Epidemiology;Epithelial Cells;FGF2 gene;fly;Funding;Genes;Genetic Risk;Genotype;Glomerular Capillary;glomerular endothelium;Grant;Growth Factor;Heparan Sulfate Proteoglycan;Heparin Binding;high risk;HIV;HIV-1;HIV-infected adolescents;Human;Infection;Injury;Injury to Kidney;Kidney;kidney cell;Knowledge;Membrane;Modernization;mouse model;Mus;Names;Outcome;Pathogenesis;Pathway interactions;perinatal HIV;Permeability;Persons;Pharmaceutical Preparations;Phenotype;Plasma;podocyte;Positioning Attribute;Precipitating Factors;Process;programs;Proteins;receptor;recruit;renal epithelium;rho;Risk;Risk Factors;risk variant;Role;Sampling;Signal Pathway;Structure;synergism;Technology;Testing;TNF gene;transcriptome;Transgenic Mice;Transgenic Organisms;Tubular formation;urinary;Urine;Vascular Endothelial Growth Factors;Viral Proteins;Viral reservoir

PROJECT_TITLE: Role of bFGF low affinity receptors in childhood HIVAN

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Hematopoietic Stem and Progenitor Cells (HSPCs) form de novo from endothelial cells strictly during early embryonic development and then maintain hematopoiesis lifelong. In this proposal, I will explore how regulation of pre-mRNA splicing controls this process, which could have implications for understanding and developing therapeutics for hematological malignancies with defective splicing.

PI_NAMEs: KARP, ILANA N (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: 3' Splice Site;Adult;Alternative Splicing;Automobile Driving;Binding Proteins;Blood Cells;cell type;Cells;cis acting element;Cis-Acting Sequence;Complex;Computer Analysis;Data;Defect;differential expression;Disease;Embryo;Embryonic Development;Endothelial Cells;Endothelium;Event;experience;experimental study;Genetic;genetic manipulation;Genetic Transcription;Health;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;hemogenic endothelium;in vivo;Introns;Knowledge;Learning;Length;Life;Literature;Measures;Morphology;mRNA Precursor;mutant;Pathway interactions;pharmacologic;Pilot Projects;Play;Process;Production;programs;promoter;Protein Isoforms;recruit;Regulation;Regulatory Element;Reporter;RNA Binding;RNA Splicing;RNA-Binding Proteins;Role;Sampling;self-renewal;Site;Spliceosomes;Surveys;Testing;Therapeutic;tool;Trans-Activators;transcriptome sequencing;Validation;Zebrafish

PROJECT_TITLE: Regulation of Splicing During Hematopoietic Stem and Progenitor Cell Formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Influenza;Multiple Sclerosis;Neurodegenerative;Neurosciences;Pneumonia and Influenza

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE B cells are a heterogeneous population of immune cells necessary for the humoral response against infections such as influenza or SARS-CoV2, the long-term immune protection afforded by vaccines, and the pathogenesis of many autoimmune diseases such as multiple sclerosis. However, the predominant therapy targeting B cell biology is rituximab, which virtually depletes all peripheral B cells and leads to many adverse effects. A better understanding of how different ion channels and transporters contribute to various B cell functions may reveal a novel repertoire of druggable targets with which B cells can be immuno-modulated.

PI_NAMEs: TAO, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 2019-nCoV;Acidity;Address;Adoptive Transfer;Adverse effects;Affect;Antibodies;Antibody-mediated protection;Antibody-Producing Cells;Antigens;antiviral immunity;Apoptotic;Attenuated;Autoantibodies;Autoimmune Diseases;Autophagocytosis;B cell therapy;B-Cell Activation;B-Cell Acute Lymphoblastic Leukemia;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Bicarbonates;Biological Products;Cardiovascular Diseases;Cell Compartmentation;Cell Physiology;cell type;Cells;Cellular biology;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;CRISPR screen;Defect;differentiation in vitro;Disease;Drug Targeting;druggable target;Erythrocytes;Experimental Autoimmune Encephalomyelitis;extracellular;forward genetics;functional genomics;Genes;Genetic Screening;Guide RNA;Hematopoietic stem cells;Humoral Immunities;humoral immunity deficiency;Immune;Immune response;Immune System Diseases;Immunize;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;Immunology procedure;immunoregulation;Impairment;In Vitro;in vivo;Infection;Influenza;Influenza A virus;influenza infection;influenza virus strain;Ion Channel;Ion Transport;Ions;Lipid Bilayers;mammalian genome;Mature B-Lymphocyte;Measures;Mediating;Mediator;Membrane Proteins;Metabolic;Modeling;Molecular;Molecular Target;Monoclonal Antibodies;mouse model;mRNA Expression;MS4A1 gene;Multiple Sclerosis;Mus;Neurology;neutralizing antibody;new therapeutic target;novel;novel drug class;oligodendrocyte-myelin glycoprotein;Outcome;Pathogenesis;Pathologic;Pathway interactions;Peripheral;pharmacologic;Physiological;plasma cell differentiation;Plasma Cells;Play;Population Heterogeneity;PRDM1 gene;Production;Proliferating;Proteins;reconstitution;Regulation;response;retroviral transduction;rituximab;Role;Severities;Sheep;side effect;Signal Pathway;Signal Transduction;small molecule;Specificity;symporter;System;Testing;tositumomab;transcriptome sequencing;transcriptomics;Vaccines;Validation;Viral;Viral Physiology;virtual;Virus Diseases

PROJECT_TITLE: The role of ion channels and transporters in B cell function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-H(20)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative  The statistical methods developed in this research will lead to improved estimation of the effects of interventions to prevent infectious diseases. Accurate and precise quantification of intervention effects are important in regulatory decisions and public health policy regarding infectious disease control.

PI_NAMEs: HUDGENS, MICHAEL G (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: Acceleration;Affect;Beds;Cholera Vaccine;Communicable Diseases;Communities;cost;Cox Models;Data;Disease;disorder control;disorder prevention;econometrics;Education;Event;experimental study;Failure;Grant;Health;Health Benefit;Health Policy;Herd Immunity;improved;Individual;Infection;Influenza;influenza virus vaccine;innovation;insight;interest;Intervention;intervention effect;Knowledge;Malaria;Measures;Methods;Modeling;Nomenclature;Observational Study;Outcome;pathogen;Pathway Analysis;Performance;Pneumococcal vaccine;Policies;Politics;prevent;Probability;Property;Public Health;Randomized;Relaxation;Research;research study;Rotavirus Vaccines;Sampling;Science;simulation;social;software development;Statistical Methods;Structure;Time;treatment effect;user friendly software;Vaccinated;Vaccination;vaccine trial;Vaccines

PROJECT_TITLE: Causal Inference in Infectious Disease Prevention Studies

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The overall mission of the Region 2 office will be to advance the progress of medicine and improve the public's health by providing researchers, health professionals, public health workforce, educators, and the public in the Southeast with equal access to biomedical and health information resources and data. The Medical University of South Carolina (MUSC) Libraries is pleased to provide this cooperative agreement application to host the Network of National Libraries of Medicine Regional Medical Library (RML) for Region 2.

PI_NAMEs: JONES, SHANNON D (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Accountability;Address;Area Health Education Centers;Awareness;Centers for Disease Control and Prevention (U.S.);Collaborations;Communication;Communities;community organizations;cultural competence;Data;Data Science;Development;Diverse Workforce;Education;Emergency medical service;emergency preparedness;Emergency response;Emergency Situation;Ensure;Evaluation;exhibitions;Exhibits;Face;Facilities and Administrative Costs;Florida;forging;Funding;Goals;Health;health inequalities;Health Personnel;Health Professional;Human Resources;Improve Access;improved;Individual;Information Resources;innovation;Internet;Intervention;Knowledge;Leadership;Learning;Librarians;Libraries;Maintenance;Medical;Medical Libraries;Medicine;meetings;member;minority health;Mission;Mississippi;Natural Disasters;open data;outreach;Pathway interactions;Poverty;programs;Public Health;Puerto Rico;recruit;Reporting;Research;Research Personnel;Resources;Running;Rural Health;service delivery;Services;South Carolina;support network;Tennessee;tool;Training;U-Series Cooperative Agreements;United States Health Resources and Services Administration;United States National Library of Medicine;United States Virgin Islands;Universities;workforce needs

PROJECT_TITLE: Region 2  Regional Medical Library, NNLM


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Kaposi’s sarcoma-associated herpesvirus (KSHV) causes several human cancers including Kaposi’s sarcoma, primary effusion lymphoma and multicentric Castleman’s disease. These malignancies inflict morbidity and mortality to the society in US and worldwide. This project will investigate the mechanisms underlining the development of these malignancies and KSHV infection by focusing on metabolic pathways, and identify therapeutic targets for developing novel prevention and treatment approaches.

PI_NAMEs: GAO, SHOU-JIANG  (contact)

PROJECT_TERMS: 3-Dimensional;Abbreviations;Acquired Immunodeficiency Syndrome;aerobic glycolysis;Amino Acids;Animal Model;argininosuccinate synthase;Biological Models;cancer cell;cancer type;carcinogenesis;Cell Culture Techniques;cell transformation;Citric Acid Cycle;Citrulline;Consumption;Development;effectiveness evaluation;Ensure;Enzyme Inhibition;Enzymes;expectation;Genes;Glucose;Glutamine;Goals;Herpesviridae Infections;Human;Human Herpesvirus 8;innovation;Kaposi Sarcoma;knockout gene;Malignant Neoplasms;Mediating;Mesenchymal Stem Cells;Metabolic;Metabolic Pathway;metabolic profile;metaplastic cell transformation;MicroRNAs;Modeling;Morbidity - disease rate;mortality;Multicentric Angiofollicular Lymphoid Hyperplasia;multidisciplinary;new therapeutic target;Nitric Oxide;Nitrogen;NOS2A gene;novel;novel therapeutics;nucleotide metabolism;Nucleotides;Oncogenic;Pathway interactions;Patients;pharmacologic;Prevention;primary effusion lymphoma;Proliferating;Proteins;Regulation;Role;Signal Induction;Signal Transduction;Signaling Molecule;Societies;STAT3 gene;Technology;Testing;Therapeutic;therapeutic target;tumor;tumorigenesis;Up-Regulation;urea cycle;Warburg Effect;Work

PROJECT_TITLE: Citrulline-urea cycle in KSHV cellular transformation

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

PROJECT_TERMS: Accountability;Address;Area Health Education Centers;Awareness;Caliber;Centers for Disease Control and Prevention (U.S.);Collaborations;Communication;Communities;community organizations;cultural competence;Data;Disasters;Emergency medical service;emergency preparedness;Emergency response;Emergency Situation;Ensure;Evaluation;Face;Facilities and Administrative Costs;Florida;forging;Funding;Goals;Health;health inequalities;Health Personnel;Health Professional;Human Resources;improved;Individual;Information Resources;Internet;Leadership;Librarians;Libraries;Maintenance;Medical;Medical Libraries;Medicine;meetings;member;minority health;Mission;Mississippi;Natural Disasters;Pathway interactions;Poverty;programs;Public Health;Puerto Rico;recruit;Research Personnel;Resources;Rural Health;service delivery;Services;South Carolina;support network;Tennessee;tool;Training;U-Series Cooperative Agreements;United States Health Resources and Services Administration;United States National Library of Medicine;United States Virgin Islands;Universities;workforce needs

PROJECT_TITLE: Admin Core - Region 2 Regional Medical Library, NNLM


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health

PROJECT_TERMS: Acceleration;Address;Area Health Education Centers;Awareness;Centers for Disease Control and Prevention (U.S.);Collaborations;Communication;Communities;community organizations;Data;data management;Data Science;Decision Making;Development;Diverse Workforce;Education;Emergency medical service;emergency preparedness;Ensure;Evaluation;exhibitions;Exhibits;Face;Facilities and Administrative Costs;Florida;forging;Funding;Future;General Population;Health;health inequalities;Health Personnel;Health Professional;Health Sciences;Healthcare;Improve Access;improved;Information Resources;innovation;Internet;Intervention;Knowledge;Learning;Librarians;Libraries;Medical;Medical Libraries;Medicine;meetings;member;minority health;Mission;Mississippi;Natural Disasters;open data;outreach;Pathway interactions;Positioning Attribute;Poverty;programs;Public Health;Puerto Rico;Research;Research Personnel;Resources;Rural Health;science teacher;Services;South Carolina;support network;Tennessee;tool;Touch sensation;Training;Training Programs;U-Series Cooperative Agreements;United States Health Resources and Services Administration;United States National Institutes of Health;United States National Library of Medicine;United States Virgin Islands;Universities;Work;workforce needs

PROJECT_TITLE: Region 2 Regional Medical Library - RML Core


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: EAST LANSING

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative: Selective molecular recognition is profoundly important for understanding molecular biology and human health. Advances in computational algorithms will enable molecular simulations of flexible biomolecular interactions bringing insights into peptide signaling and bacteriophage host recognition.

PI_NAMEs: DICKSON, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Affect;Algorithms;antagonist;Award;Bacteria;bacteriophage tailspike protein;Bacteriophages;Binding;Binding Proteins;Binding Sites;Biological Process;biological systems;Biology;calcitonin receptor-like receptor;cancer cell;Carbohydrates;Cell Communication;Cell Line;Cell surface;Cell Wall;Cells;chemical reaction;Chemicals;cofactor;Collaborations;Communities;Complex;Computational algorithm;Computer software;Computing Methodologies;Data Set;design;Detection;Development;dynamic system;Equilibrium;Event;Evolution;Exhibits;experience;extracellular;Extracellular Domain;flexibility;Free Energy;Freedom;G-Protein-Coupled Receptors;Glean;Health;Hormones;Human;human pathogen;Immune response;improved;innovation;insight;interest;Kinetics;Knowledge;Learning;Length;Ligands;Lipopolysaccharides;Markov Chains;Measurement;member;Methodology;Methods;migraine treatment;Modeling;Molecular;Molecular Biology;Molecular Computations;Molecular Conformation;molecular dynamics;molecular recognition;Motion;mutant;nanoscale;nanosecond;Nature;Neuropeptides;Neurotransmitter Receptor;novel therapeutics;Organism;Parents;Pathway interactions;peptide hormone;Peptide Receptor;Peptide Signal Sequences;Peptides;Pharmaceutical Preparations;Probability;Process;Protein Conformation;Proteins;receptor;receptor-activity-modifying protein;Research Personnel;Role;Running;Sampling;Serotyping;Shigella flexneri;Signal Transduction;simulation;Specificity;success;System;Therapeutic;Time;tool;transmission process;Uncertainty;United States National Institutes of Health;Variant;Virion;Virus;Work

PROJECT_TITLE: Revealing pathways and kinetics of molecular recognition with advanced molecular simulation algorithms

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: YORK

ORG_NAME: ASSOCIATION OF FOOD AND DRUG OFFICIALS

PHR: AFDO Application for RFA-FD-20-024 - PROJECT NARRATVE AFDO’s National Curriculum Standard Development and Training Delivery and Development proposal is intended to facilitate long term improvements to the national food safety system through the establishment of a coordinated effort focused on human and animal food training (including Retail Food, Manufactured Food, Animal Food, Produce, Milk, Laboratory, and Shellfish) for government regulatory officials. Efforts will include continued development of the Integrated Food Safety System (IFSS) National Curriculum Standard (NCS) competency and curriculum frameworks, further development and validation of competency statements and behavior anchors, delivery of classroom and virtual training in conjunction with FDA, development of new and existing classroom and web-based courses, and evaluation of existing training processes and procedures. By contributing to the development of a well- coordinated National Curriculum Standard and training system, AFDO will significantly advance a national IFSS and effectively fulfill the requirements of the Food Safety Modernization Act. Ultimately, the safety, security, and defense of the United States food supply will improve.

PI_NAMEs: MANDERNACH, STEVEN  (contact)

PROGRAM_OFFICER_NAME: WERNICK, MARC

PROJECT_TITLE: Continuing to support the Integrated Food Safety System (IFSS) National Curriculum Standard (NCS) through course development, delivery, and ongoing evaluation


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SEATTLE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE This proposal will evaluate and validate new quantitative imaging markers of vascular and neurodegenerative mechanisms underlying white matter hyperintensities (WMHs). We will test whether these markers mediate specific cognitive decline via higher burden of periventricular and subcortical, punctate WMHs. Knowledge gained could be used for precision medicine approaches to stratify individuals based on their predominant pathological mechanism for WMHs formation and alleviate subsequent cognitive decline.

PI_NAMEs: RANE LEVENDOVSZKY, SWATI  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Actins;Affect;Albumins;Alzheimer's Disease;Alzheimer's disease risk;Anatomy;Appearance;arterial spin labeling;Arteries;Atrophic;Autopsy;Axon;Benchmarking;Biological Markers;biomarker validation;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain tissue;Cell Adhesion Molecules;cerebral atrophy;Cerebral cortex;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular pathology;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive testing;cohort;Corpus striatum structure;Dementia;Demyelinations;density;Diameter;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;E-Selectin;Endothelium;Ensure;executive function;Extravasation;feeding;Fiber;Functional Magnetic Resonance Imaging;Future;glial activation;gray matter;Growth;hypoperfusion;Image;imaging biomarker;immunohistochemical markers;Impaired cognition;Impairment;in vivo;in vivo imaging;Individual;Inflammation;Inflammatory;innovation;intercellular cell adhesion molecule;Interruption;Ipsilateral;Knowledge;Liquid substance;Location;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;Mediating;Mediation;Mediator;Methods;mild cognitive impairment;Myelin;Myelin Basic Proteins;Nerve Degeneration;Nerve Fibers;neural;Neurobehavioral Manifestations;Neurons;neuropathology;novel;older adult;Oligodendroglia;Participant;Pathologic;Pathologic Processes;Pathology;Perfusion;precision medicine;prevent;Prevention;Process;processing speed;quantitative imaging;recruit;Research;Resources;Risk Factors;Sampling;Severities;Smooth Muscle;Specificity;Spinal Puncture;Stains;Structure;success;System;tau Proteins;Techniques;Testing;Time;Tissue Sample;Tissues;Universities;Validation;Vascular Cell Adhesion Molecule-1;vascular injury;Ventricular;Washington;Water;white matter;white matter damage;White Matter Hyperintensity;Work

PROJECT_TITLE: Pathological mechanisms of white matter hyperintensities

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Childhood Obesity;Maternal Health;Neurosciences;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE The proposed research advances our understanding of how birth mode affects development. The same hormones that are involved in birth also regulate metabolism, and when we manipulate these hormones to help improve birth outcomes, we may be producing long-term changes in offspring metabolism and weight gain. The proposed work will help us understand how these common birth interventions may impact the development of the fetal brain and subsequent health.

PI_NAMEs: KENKEL, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: BROCKWAY, HEATHER MARIE

PROJECT_TERMS: Adrenal Cortex Hormones;Adult;Affect;Anatomy;Animals;Argipressin;Behavior;Birth;Body Composition;Body Temperature;Brain;Brain region;Budgets;Cesarean section;Child;Childhood;Chronic;cold stress;Complement;Corticosterone;corticosterone receptor;cost effective;Dangerousness;data streams;Desire for food;Development;Eating;Endocrine;energy balance;Energy Metabolism;Equilibrium;experience;Fetal Development;food consumption;Health;Heart Rate;Histology;Home;hormonal signals;hormone regulation;Hormones;Housing;Human;Hypothalamic structure;Implant;improved;Intervention;late life;lens;Life;Ligands;Mammals;Measures;Metabolic;Metabolism;Microtus;Modeling;morphometry;Motor Activity;Nature;Neuroendocrinology;neuroimaging;Neuropeptides;neuroregulation;Neurosecretory Systems;Newborn Infant;novel;Obesity;obesity development;obesity in children;obesity risk;offspring;Outcome;Oxytocin;pharmacologic;Physiologic Thermoregulation;Physiology;Play;Population;prairie vole;preference;Prevalence;Public Health;Regulation;Research;Rest;Rewards;Risk;Risk Factors;Rodent;Rodent Model;Role;Signal Transduction;Social Behavior;Sucrose;Surveys;System;Technology;Temperature;Testing;United States;Vaginal delivery procedure;Vasopressins;Visceral;Weight Gain;Work

PROJECT_TITLE: Avoiding Cesarean-induced Obesity Through Hormone Rescue

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Nutrition;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

PHR: Project Narrative:  This is a revised grant application focusing on “Alterations in Post-Receptor Insulin Signaling in Diabetes and Insulin Resistance.” In very recent studies, we have used iPS cell-derived myoblasts from humans with type 2 diabetes (T2D) to identify cell autonomous components of insulin resistance in human disease and in the process also identified two new transcription factors whose phosphorylation is dysregulated in T2D, FoxK1 and FoxK2. Going forward, we will 1) elucidate the fundamental differences in insulin signaling in T2D and insulin resistance in vitro using targeted and global phosphoproteomics of human iPS cell-derived myoblasts from normal individuals, T2D patients and non-diabetic individuals with insulin resistance and 2) define the role of FoxK1 and FoxK2 in insulin regulated gene expression and how this is linked to alterations in cellular function diabetes.

PI_NAMEs: KAHN, C RONALD (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Affect;Applications Grants;Attention;cell growth regulation;Cell model;Cell Nucleus;Cell Physiology;Cells;ChIP-seq;combinatorial;Complement;Coupling;Data;Defect;Development;Diabetes Mellitus;diabetes mellitus therapy;Diet;Dimensions;Disease;Environmental Risk Factor;Exclusion;Fatty acid glycerol esters;FOXO1A gene;FRAP1 gene;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genomics;Goals;Grant;Growth;gut microbiome;Human;human disease;human induced pluripotent stem cells;IGF1R gene;In Vitro;in vivo;Individual;induced pluripotent stem cell;insight;Insulin;insulin mediators;Insulin Receptor;insulin regulation;Insulin Resistance;insulin sensitivity;insulin signaling;Insulin Signaling Pathway;Insulin-Like Growth Factor I;Knock-out;Link;Liver;MAPK8 gene;Mediating;Metabolic;Metabolic syndrome;Metabolism;Modeling;Molecular Profiling;Mouse Strains;Mus;Muscle;Myoblasts;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nuclear;Pathway interactions;Patients;phosphoproteomics;Phosphorylation;Phosphotransferases;PIK3CG gene;Population;Process;Proteins;Proteomics;Publications;receptor;receptor coupling;Regulation;Role;Signal Pathway;Signal Transduction;Site;stress kinase;System;Tissues;transcription factor;Work

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Genetics;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Cell fate is controlled by master regulators. The proposed project will examine such a regulator that has the ability to convert glial cells into neurons in living animals. These new neurons may contribute to regeneration- based therapies for patients with traumatic neural injuries or neurodegeneration.

PI_NAMEs: ZHANG, CHUN-LI  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Adult;adult neurogenesis;Animals;Astrocytes;Axon;Behavior;Biological Process;Brain;Cell Physiology;Cell Transplantation;Cells;Central Nervous System;ChIP-seq;Cicatrix;Clinical;CSPG4 gene;Data;deep sequencing;DNA Binding Domain;Environment;functional improvement;Gene Modified;Genetic;genome-wide;Goals;Immune;in vivo;Induced Neurons;Injury;injury recovery;Laboratories;mad itch virus;Mediating;migration;Modeling;Molecular;Motor;mouse model;Mus;Nerve Degeneration;nerve injury;Nerve Regeneration;nerve stem cell;Nervous System;neural circuit;neural repair;neurogenesis;Neuroglia;neuron loss;neuronal excitability;neuronal survival;Neurons;neurotrophic factor;Outcome;patch clamp;Pathologic;Patients;Play;Population;postsynaptic;presynaptic;Process;programs;Proliferating;Rabies virus;recombinant virus;Recombinants;Recovery of Function;regenerative therapy;repaired;Research;response;Role;Series;Signal Pathway;single-cell RNA sequencing;Specific qualifier value;Spinal Cord;Spinal cord injury;Stem Cell Factor;Synapses;transcription factor;Transcriptional Activation Domain;Traumatic injury;tumorigenesis;Vesicular stomatitis Indiana virus;Work

PROJECT_TITLE: PAX6-induced adult neurogenesis

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF-M]


NIH_SPENDING_CATS: Cardiovascular;Childhood Obesity;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Women who are under- or overweight at the start of their pregnancy are at higher risk of problems during pregnancy and birth. Doctors recommend that women gain or lose weight so they will be at a healthy weight before getting pregnant, but our research shows that changes in weight right before pregnancy might make it harder for women to gain a healthy amount of weight while they are pregnant. In this study, we will use medical record data from more than 130,000 women and their children to test how different patterns of weight change before and during pregnancy affect the health of women and their children.

PI_NAMEs: BOONE-HEINONEN, JANNE ;VESCO, KIMBERLY KRISTINE (contact)

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: 3 year old;Academy;adverse birth outcomes;adverse outcome;adverse pregnancy outcome;Affect;antenatal;Benefits and Risks;Birth;Birth Weight;Body mass index;Body Weight Changes;Body Weight decreased;Caring;Cesarean section;Child;Childhood;Classification;Clinical;clinical data warehouse;clinical risk;Conceptions;critical period;Data;Diabetes Mellitus;Diagnosis;Dietary Intervention;early pregnancy;Environment;Ethnic Origin;Ethnic Population;evidence base;experience;follow-up;Future;Gestational Age;Gestational Diabetes;gestational weight gain;Growth;Guidelines;Health;healthy weight;Height;high body mass index;high risk;Hormonal;Hypertension;improved;improved outcome;Infant;Intervention;Intervention Trial;Length;lifestyle intervention;Literature;Longterm Follow-up;Maintenance;Maternal and Child Health;maternal weight;Measures;Mediating;Medical Records;Medicine;Metabolic;Mothers;Obesity;Observational Study;Outcome;Overweight;Pattern;Perinatal;Population;post pregnancy;Postpartum Period;postpartum weight;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy hypertension;Pregnancy Outcome;pregnant;Premature Birth;prepregnancy;programs;Race;Recommendation;Research;Research Personnel;Risk;risk minimization;Risk Reduction;Sampling;Shapes;Small for Gestational Age Infant;socioeconomics;Spontaneous abortion;Subgroup;success;Testing;treatment arm;Underweight;Weight;Weight Gain;Weight maintenance regimen;Weights and Measures;Woman;Women's Health;Work

PROJECT_TITLE: MatTrack: The impact of preconception maternal weight trajectories on maternal, pregnancy, and child outcomes

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Pediatric

ORG_CITY: Aurora

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The Rocky Mountain Summer Research Education Experience (RMSREE) Program will provide substantive research training, individualized academic preparation, and career guidance to strongly enhance the skills of the high school teacher participants in the fields of biomedical imaging, bioengineering, and health informatics. The project is designed to aid them in translating their research experience into enhanced STEM education in their classrooms and to provide them with professional development opportunities to effectively bridge the gap between the research setting to the high school STEM classroom.

PI_NAMEs: KIMBROUGH, DORIS R;REED, SCOTT M (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: academic preparation;Area;Behavioral Research;Behavioral Sciences;Biomedical Engineering;biomedical imaging;Biomedical Research;career;Clinical Research;Clinical Sciences;cohort;design;Development;Development Plans;Education Projects;education research;Educational process of instructing;expectation;experience;Fostering;Future Teacher;Goals;high school;High School Faculty;improved;Individual;individualized feedback;K-12 Education;Knowledge;Laboratory culture;medical specialties;Mentors;Outcome;Participant;Performance;programs;Public Health Informatics;recruit;Research;Research Training;responsible research conduct;Science;Science, Technology, Engineering and Mathematics Education;Series;skills;STEM field;Students;success;summer research;teacher;Training;Translating;Underrepresented Populations;United States National Institutes of Health;Vocational Guidance;Work


NIH_SPENDING_CATS: Cancer

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: There is continued and substantial need for new researchers who will apply cutting-edge knowledge and interdisciplinary techniques to develop new cancer therapies, diagnostics and preventions. This application seeks to meet this need by continuing the long-standing and successful training program at the University of California, Irvine, now named a Training Program for Interdisciplinary Cancer Research. The program provides opportunities for predoctoral and postdoctoral trainees to develop expertise in cancer research, diagnosis and treatment by learning from leading faculty who approach the cancer problem from diverse scientific perspectives using a broad array of modern, interdisciplinary approaches.

PI_NAMEs: EDINGER, AIMEE L;FRUMAN, DAVID ALEXANDER (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: anti-cancer research;Training Programs

PROJECT_TITLE: A Training Program for Interdisciplinary Cancer Research


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rare Diseases;Sleep Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The proposed R01 investigates the effects of circadian-effective light on Multiple Myeloma patients receiving Autologous Stem Cell Transplantation. The public health relevance of this study is significant because it will determine if circadian-effective light, an inexpensive and low patient burden intervention, results in circadian rhythm entrainment, reduction of pro- inflammation cytokines, reduced occurrence of neutropenic fever, and low symptom burden.

PI_NAMEs: FIGUEIRO, MARIANA GROSS;VALDIMARSDOTTIR, HEIDDIS  (contact)

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: 6-sulfatoxymelatonin;actigraphy;Affect;associated symptom;Autologous Stem Cell Transplantation;Biological;cancer therapy;CCL2 gene;circadian;Circadian Rhythms;clinically significant;cytokine;Data;design;disease prognosis;Doctor of Medicine;Drowsiness;Engraftment;Ensure;Equipment and supply inventories;experience;Exposure to;follow-up;Hormone secretion;Hospitals;Hour;improved;improvement on sleep;Inflammation;Inflammatory;inflammatory marker;innovation;Interleukin-6;Intervention;intervention effect;Intervention Studies;Light;Lighting;Measures;Mediating;Melatonin;Mental Depression;Multiple Myeloma;Neutropenic Fever;Outpatients;Pain;Pathway interactions;Patients;Patients' Rooms;Phase;Phototherapy;Production;Prognosis;psychologic;Public Health;public health relevance;Quality of life;Randomized, Controlled Trials;Recovery;reduce symptoms;Research;Rest;Risk;side effect;Site;Sleep;sleep onset;sleep quality;Sleep Wake Cycle;Symptom Burden;Symptoms;System;Temperature;Testing;Time;TNF gene;Transplant Recipients;Transplantation;urinary;Urine

PROJECT_TITLE: Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lupus;Sepsis

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE (Public Health Relevance Statement) The proposed project—utilizing COVID-19 as a window—will endeavor to define mechanisms and consequences of infection-induced autoimmunity. Successful completion of this study will provide new insights into the role of exogenous infection in breaking self-tolerance and leading to de novo pathogenic autoantibody production. Furthermore, this proposal is likely to reveal new aspects of antiphospholipid syndrome and lupus immunopathogenesis, while at the same time potentially identifying new treatment targets for COVID-19.

PI_NAMEs: ZUO, YU  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: 2019-nCoV;Acceleration;Adhesives;Alveolar;Animal Experimentation;Animals;Anti-phospholipid Syndrome;Antibodies;Antigens;Antiphospholipid Antibodies;Area;Attention;Autoantibodies;Autoimmune Diseases;Autoimmunity;Award;Bacteria;Blood;Blood Platelets;Blood Vessels;Cardiolipins;career;career development;Cell surface;Cellular biology;Clinical;clinical phenotype;cohort;Collaborations;COVID-19;COVID-19 patient;Critical Illness;Deoxyribonucleases;Development;Disease;DNA;Endothelial Cells;Environment;Ethics;experimental study;extracellular;Fostering;Generations;Goals;Hospitalization;Hospitals;Human;Human Subject Research;Hyperactivity;Immunoglobulin G;Immunoglobulin M;Impairment;improved;improved outcome;In Situ;In Vitro;Individual;Infection;Inflammation;Inflammatory;Injury;innovation;insight;Institution;Instruction;Laboratories;large datasets;Leadership;Learning;Length of Stay;Lupus;Measures;Mediating;Medical Research;Medicine;Mentors;Mentorship;Michigan;microbicide;molecular phenotype;mortality;mouse model;Multiple Organ Failure;Mus;Neurofibrillary Tangles;neutrophil;oral communication;Organ;pandemic disease;Pathogenesis;pathogenic autoantibodies;Pathogenicity;Patient Recruitments;Patients;Physicians;Play;prevent;Production;professor;Property;prospective;Proteins;public health relevance;Regulatory Affairs;Research;Research Personnel;Rheumatism;rheumatologist;Rheumatology;Risk;Role;Scientist;Self Tolerance;Sepsis;septic patients;Serum;severe COVID-19;Severity of illness;skills;Statistical Methods;synergism;therapeutic target;Thrombin;thromboinflammation;Thrombophilia;Thrombosis;Time;tool;Training;translational scientist;Universities;Veins;Work;Writing

PROJECT_TITLE: Thromboinflammatory consequences of infection-induced autoimmunity

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CHICAGO

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Emergency department-based physical therapy is a rapidly growing resource and represents a promising treatment approach to low back pain. We propose to develop and test an innovative model of an emergency department “embedded” physical therapist to evaluate and treat patients with acute low back pain. We hypothesize that the embedded physical therapy intervention will improve patient functioning, reduce opioid use, and decrease unnecessary testing.

PI_NAMEs: KIM, HOWARD S (contact)

PROGRAM_OFFICER_NAME: IGNACZAK, AARTEE

PROJECT_TITLE: A Cluster-Randomized Trial of the Northwestern Embedded Emergency Department Physical Therapy (NEED-PT) Protocol for Acute Low Back Pain

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ORG_CITY: Bloomington

ORG_NAME: HEALTHPARTNERS INSTITUTE

PHR: Project Narrative Our team has developed, implemented, and evaluated a clinical decision support (CDS) tool to appropriately identify high blood pressure in children. In a previous study, we showed that in a large urban and suburban health system, our CDS tool successfully promoted care consistent with national guidelines, improved recognition of high blood pressure, and was well accepted by providers. This study will adapt the existing CDS for use in a primarily rural health system and compare approaches to CDS implementation in 45 primary care clinics treating children in Minnesota, Wisconsin and North Dakota, thus advancing implementation science and addressing a critical need for youth at-risk for cardiovascular disease and with limited access to pediatric subspecialty care.

PI_NAMEs: BENZIGER, CATHERINE PASTORIUS;KHARBANDA, ELYSE OLSHEN (contact)

PROGRAM_OFFICER_NAME: DELAMARE, JAN

PROJECT_TITLE: Improving Recognition and Management of Hypertension in Youth: Comparing Approaches for Extending Effective CDS for use in a Large Rural Health System

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Intermittent theta burst stimulation (iTBS) is increasingly used as a therapy for treatment resistant major depressive disorder. We propose that the overall remission rate achieved with iTBS can be enhanced by increasing the individualization of treatment parameters including frequency and location optimization. We plan to establish target engagement in the R61 phase and clinical efficacy in the R33 phase.

PI_NAMEs: DASKALAKIS, ZAFIRIS J. (contact);FITZGERALD, PAUL

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Anatomy;arm;Biological;Brain;Clinical;Clinical assessments;clinical efficacy;clinical practice;Clinical Trials;cognitive function;comparative efficacy;cost effectiveness;Coupled;Coupling;Data;depressive symptoms;Diagnosis;Disease;Disease remission;Dose;Double-Blind Method;effective therapy;Effectiveness;electric field;Electroencephalography;Ensure;Frequencies;Goals;improved;Individual;individual patient;individualized medicine;interest;Investigation;Left;Link;Location;Major Depressive Disorder;Measures;Mental Depression;Methods;Modeling;Moods;neuroimaging;Neuronal Plasticity;novel;novel strategies;Outcome;Parietal;Patients;Pattern;Performance;Phase;Physiologic pulse;Population;Prefrontal Cortex;programs;Randomized;Randomized, Controlled Trials;repetitive transcranial magnetic stimulation;Reporting;Research;Resistance;response;Rest;Safety;Severities;Short-Term Memory;Site;societal costs;symptomatic improvement;Testing;Time;Treatment Cost;Treatment Efficacy;treatment response;treatment-resistant depression;trial comparing

PROJECT_TITLE: Frequency and E-field Enhancement of iTBS for Depression (FREED)


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE This proposal focuses on (i) creation of novel technologies for rigorous and experimentally concise analysis of higher-order RNA structure, (ii) application of these technologies to compelling challenges in understanding how higher-order tertiary structures and regulatory networks govern the functions of pathogenic viruses and coding and non-coding RNAs, and (iii) illumination of principles underlying small-molecule ligandability of RNA. This project will create broadly implementable technologies for analysis of RNA structure and function, and use these to understand biological regulatory networks in novel ways, ultimately driving both basic biological discovery and RNA-targeted drug development.

PI_NAMEs: WEEKS, KEVIN M (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Automobile Driving;Back;Binding;Biological;Biological Models;Biological Process;Cells;Code;Communication;Complex;design;Development;drug development;drug discovery;Elements;Gene Expression Regulation;Genetic Transcription;Goals;Higher Order Chromatin Structure;insight;invention;Knowledge;Lighting;Mediating;Messenger RNA;Methods;Modeling;mRNA Precursor;new technology;novel;Organism;pathogenic virus;RNA;RNA analysis;RNA Conformation;RNA Folding;RNA Splicing;RNA-targeting therapy;small molecule;Structure;Technology;Untranslated RNA;Validation;Work

PROJECT_TITLE: Discovery and Function of Higher-Order RNA Structure

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative The NANO (NICU Antibiotics and Outcomes) Trial is a much-needed clinical trial to scrutinize the longstanding practice of giving antibiotics immediately at birth to nearly all preterm infants. Results from this trial will aid practitioners who regularly face the challenging decision of whether or not to prescribe antibiotics for newborns. The current proposal does not involve planning or execution of the NANO Trial itself. Rather, this proposal seeks funding to support novel longitudinal studies of the gut microbiome in NANO participants randomized to receive either broad spectrum antibiotics or placebo immediately at birth. The proposed studies will reveal new fundamental knowledge of how antibiotics at birth in humans impact inheritance of the maternal microbiome, the spread of antibiotic resistant bacterial strains, and infant gut health.

PI_NAMEs: BANFIELD, JILLIAN  (contact);MOROWITZ, MICHAEL

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Adverse effects;adverse outcome;Aerobic;Agreement;Ampicillin;Anaerobic Bacteria;Ancillary Study;Animals;antenatal;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Bacteria;Bacterial Antibiotic Resistance;Bacterial Chromosomes;Bacterial Genes;Bacteriophages;Biology;Birth;Blinded;Cell Respiration;Cessation of life;Childhood;Clinical;Clinical Trials;clinically relevant;Collection;Drug resistance;Early Diagnosis;early onset sepsis;Ecosystem;Elements;Enrollment;Equipment and supply inventories;Exposure to;Face;fitness;Formates;Funding;Genes;Genetic Induction;Genomics;Gentamicins;Gestational Age;Grant;gut health;gut microbiome;Health;Hospitals;Hour;Human;human data;Human Milk;Incidence;Infant;infant gut microbiome;inter-individual variation;Intestines;Intravenous;knock-down;Knowledge;late onset sepsis;Length;Life;Link;Literature;Longitudinal Studies;maternal microbiome;Measures;member;Metabolism;Metagenomics;microbial;microbial colonization;microbiome;microbiome analysis;microbiome research;microbiota;Mobile Genetic Elements;Mothers;Multicenter Trials;Mutation;Necrotizing Enterocolitis;Neonatal;Newborn Infant;Nitrogen;novel;opportunistic pathogen;Organism;Outcome;Outcome Study;Oxidation-Reduction;Oxygen;Participant;pathogen;Patients;Pattern;Perinatal;Placebo Control;placebo group;Placebos;Plasmids;Population;Premature Infant;preterm newborn;primary endpoint;Process;Protocols documentation;Randomized;randomized placebo controlled trial;Rectum;Reproduction;Research;Resistance;resistance gene;resistant strain;Resolution;Ribosomal RNA;Saline;Sampling;Sampling Studies;Sepsis;sex;standard of care;stool sample;Study Subject;Swab;Testing;Time;Time Series Analysis;transcriptomics;United States National Institutes of Health;Vagina;Variant;Vertical Transmission

PROJECT_TITLE: Population Genomic Analysis of Gut Microbial Colonization in Premature Infants

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: DETROIT

ORG_NAME: JOHN D DINGELL VA MEDICAL CENTER

PHR: Spiral ganglion neurons and their connections with the cochlear nucleus are vulnerable to many insults, which lead to irreversible cell damage, synapse defects, and subsequent hearing disorders. This proposal will identify the role of Progranulin in SGN-CN synapse integrity and determine whether Progranulin can rescue auditory synapse defects. The success of this proposal will significantly advance knowledge in the integrity and regeneration of auditory synapses and contribute to future clinical applications, which will replace the structure and function of damaged auditory synapses to treat auditory synapse defect patients.

PI_NAMEs: HU, ZHENGQING  (contact)

PROJECT_TERMS: AD transgenic mice;Age;age related;Area;Atrophic;Auditory;Auditory Brainstem Responses;auditory pathway;auditory processing;Auditory system;Auditory Threshold;Biological Assay;blast exposure;Brain;cell injury;Central Nervous System;clinical application;Cochlear Implants;Cochlear nucleus;cochlear synaptopathy;Coculture Techniques;congenic;Data;Defect;density;Development;enhanced green fluorescent protein;Environment;Exhibits;Functional Regeneration;Future;Glycoproteins;Green Fluorescent Proteins;GRN gene;Hair Cells;Hearing;hearing impairment;Hearing problem;Homozygote;Impairment;improved;In Vitro;in vivo;Inflammation;Injury;Inner Hair Cells;Knockout Mice;Knowledge;Labyrinth;Measurement;Messenger RNA;Methods;Molecular;mouse model;Mouse Protein;Mus;Natural regeneration;Nerve Degeneration;neural;Neurites;neuroinflammation;neuronal survival;Neurons;Noise;Noise-Induced Hearing Loss;normal hearing;novel therapeutic intervention;Outcome;Outcome Study;Patients;Peripheral;Peripheral Nervous System;PGRN gene;Pilot Projects;postnatal;Presbycusis;rehabilitation research;Reporting;Research;restoration;Rodent Model;Role;Series;Signal Transduction;speech recognition;spiral ganglion;Structure;success;Synapses;Synaptic Vesicles;synaptogenesis;Testing;Therapeutic;Traumatic Brain Injury;treatment strategy;Veterans;young adult

PROJECT_TITLE: Regeneration  of Auditory Synapses

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

PHR: Veterans with PTSD are at greater risk of poor health when compared to Veterans without PTSD. One novel mechanism suggested to explain this association is accelerated biological aging. In contrast to chronological aging, which is constant across individuals, people can age faster or slower biologically at the cellular and molecular level. People who are biologically aging faster than others are expected to face more negative health consequences over time, including more chronic disease, disability, and premature mortality. If Veterans with PTSD evidence accelerated aging, it could help explain one way in which PTSD might translate to poorer health. Importantly, behavioral interventions have been shown to prevent accelerated aging. If empirical evidence could point to plausible behavioral mechanisms that are linked to both PTSD and accelerated aging, such mechanisms would present promising intervention targets to improve health among Veterans with PTSD, ideally earlier in the lifespan before the effects of ill health have accumulated.

PI_NAMEs: BOURASSA, KYLE J. (contact)

PROJECT_TERMS: Affect;Afghanistan;Age;age acceleration;Aging;Award;Behavior Therapy;Behavioral Mechanisms;Biological Aging;Biological Markers;career;Cessation of life;Characteristics;Chronic Disease;Chronology;Clinical;cohort;comorbidity;cost;Data;Data Collection;Development;disability;Disease;DNA Methylation;Electronic Health Record;experience;Face;Goals;Health;Health behavior;Health Care Costs;health care service utilization;health data;Health Personnel;Human;IgE;improved;Individual;Intervention;Iraq;life span;Link;Measures;Mental disorders;Mental Health;Mentors;Mentorship;Methodology;Methods;Methylation;middle age;military veteran;Molecular;novel;Outcome;Persons;Physiological;Population;Post-Traumatic Stress Disorders;premature;Premature Mortality;prevent;psychosocial;Research;Research Personnel;Risk;Sampling;Scientist;Site;Social support;Speed;Testing;theories;Time;Training;Translating;uptake;Veterans;Work

PROJECT_TITLE: Posttraumatic Stress Disorder, Accelerated Biological Aging, and Veteran Health


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Substance Misuse Prevention;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Project Narrative Undergraduate women are at increased risk for sexual assault (SA) during acute alcohol intoxication due, in part, to the effects of acute alcohol intoxication on the ability to perceive SA risk cues. Given the relevance of emotions to decision-making and assessment of risk, a critical next step in this line of research is to investigate whether state emotions influence SA risk perception during acute alcohol intoxication. The proposed study will help inform the development and refinement of strategies to prevent alcohol-involved SA among undergraduate women by using an innovative, multi-method experimental paradigm to examine the influence of both negative and positive emotion states on SA risk perception during acute alcohol intoxication.

PI_NAMEs: KIEFER, REINA  (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Acute;aged;Alcohol consumption;alcohol effect;alcohol involvement;alcohol myopia;alcohol prevention;Alcoholic Intoxication;Alcohols;Anger;Arousal;Attention;attentional bias;Bacterial Artificial Chromosomes;biological adaptation to stress;Biological Markers;career;Cognitive;cognitive change;college;Cues;Decision Making;design;Development;Dose;emotion regulation;Emotional;Emotions;Environment;experience;experimental group;Faculty;Funding;Galvanic Skin Response;heart rate variability;Impaired cognition;improved;indexing;Individual;innovation;Institution;Intoxication;Judgment;Knowledge acquisition;Laboratories;Laboratory Study;Lead;Link;Literature;Measures;Methodology;Methods;National Institute on Alcohol Abuse and Alcoholism;National Research Service Awards;Participant;Patient Self-Report;Positioning Attribute;positive emotional state;prevent;Prevention program;programs;Psychophysiology;Randomized;Regulation;Reporting;Research;research and development;Research Personnel;response;Risk;Risk Assessment;risk perception;Risk Reduction;Role;sexual assault;skill acquisition;skills;sobriety;Stimulus;Strategic Planning;Stress;Testing;theories;Training;undergraduate student;United States National Institutes of Health;Woman

PROJECT_TITLE: Assessing State Emotions and Acute Alcohol Intoxication on Sexual Assault Risk Perception


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative: The size of a meal is thought to be regulated by interactions between signals of long-term energy balance and caudal brainstem circuits that directly control meal termination, but how this interaction is encoded in the dynamics of the underlying brainstem circuits remains unknown. Here, I will investigate this problem by simultaneously manipulating hypothalamic circuits and leptin while recording the natural dynamics of caudal brainstem circuits or measuring their effect on feeding behavior. This work will advance our understanding of how long-term and short-term systems regulating energy balance interact to control meal size, which is an important determinant of overall food intake and can be dysregulated in conditions like obesity.

PI_NAMEs: LY, TRUONG  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Ablation;Address;Adult;Area;Automobile Driving;awake;Behavior;Brain;Brain Stem;cell type;Cells;Cholecystokinin;Cranial Nerves;Cues;Eating;Elements;energy balance;Exhibits;experimental study;Fasting;Feedback;feeding;Feeding behaviors;Food;Gastrointestinal tract structure;Glucagon;Glutamates;Hormones;Hunger;Hypothalamic structure;in vivo;in vivo evaluation;Infusion procedures;Ingestion;Leptin;Logic;mature animal;Measures;Mus;neonatal mice;neonate;neural;Neurons;Nucleus solitarius;Nutrient;Obesity;optogenetics;Oral Ingestion;Peptides;Phase;Photometry;Population;prevent;Prolactin-Releasing Hormone;Regulation;Reporting;response;Role;Satiation;Sensory;sensory feedback;Signal Transduction;Starvation;Structure;Structure of nucleus infundibularis hypothalami;System;Taste Perception;Testing;Time;Work

PROJECT_TITLE: Investigating how long-term signals modulate brainstem satiation circuits


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: Los Angeles

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: The goal of this training grant is to educate a cadre of outstanding scholars seeking either a PhD degree or postdoctoral training (for both DDS/MD and PhD graduates) to pursue basic, fundamental, translational, or clinical research and prepare for careers relevant to dental and craniofacial disease and health. We recognize the significant contributions of international scientists, clinician-scientists and underrepresented minorities to dental and craniofacial research, mentoring, and teaching; and, we strive to appoint trainees with very diverse research experiences, background and education. Our aim is to develop a diverse cohort of independent scientists who will have a significant impact on the dental, oral and craniofacial health-related research needs of the nation, and the world.

PI_NAMEs: PAINE, MICHAEL LANSDELL (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Address;Applications Grants;Appointment;Award;Behavioral Research;Biology;Biomedical Research;Clinical;Clinical Research;cohort;craniofacial;Dental;Dental Education;Discipline;Disease;Doctor of Philosophy;Education;Educational process of instructing;Educational workshop;Enrollment;Ensure;Faculty;Financial Support;Fostering;Funding;Future;Goals;Grant;Health;Institution;interest;International;Interview;Investments;medical schools;Mentors;Mentorship;Mission;National Institute of Dental and Craniofacial Research;National Research Service Awards;next generation;Oral;Oral health;Outcome;Peer Review Grants;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Principal Investigator;programs;Qualifying;Recording of previous events;Research;Research Personnel;Research Training;role model;School Dentistry;Scientist;Time;Training;training opportunity;Training Programs;Underrepresented Minority;Workplace;Writing

PROJECT_TITLE: Doctoral and Post-doctoral Training in Craniofacial Biology


NIH_SPENDING_CATS: Kidney Disease

ORG_STATE: TX

PHR: PROJECT NARRATIVE Renal fibrosis is a common manifestation of chronic kidney disease that contributes to eventual organ failure requiring dialysis or transplant. In order to develop new therapies to target renal fibrosis, we need to understand the normal cellular and molecular mechanisms that may be co-opted or altered during disease. In this project, we will investigate the normal developmental role and regulation of pericytes, a unique type of supportive cell that surrounds blood vessels and has been shown to contribute to fibrosis.

PI_NAMEs: LUO, PETER  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Ablation;Arteries;Biological Assay;Blood capillaries;blood filter;Blood Vessels;Cause of Death;Cell Differentiation process;Cell Maturation;Cell-Matrix Junction;Cells;Chronic Kidney Failure;COL6A1;Collagen;Collagen Gene;Collagen Type VI;CSPG4 gene;Cues;Data;Deposition;Development;Developmental Process;Dialysis procedure;differentiation in vitro;Disease;End stage renal failure;Endocrine;Endothelial Cells;Endothelium;Ensure;Etiology;Extracellular Matrix;Fibrosis;Future;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Healthcare Systems;Immunofluorescence Immunologic;In Situ Hybridization;In Vitro;in vitro Model;in vivo;Investments;Kidney;kidney cortex;Kidney Diseases;Kidney Failure;kidney fibrosis;kidney vascular structure;knock-down;Knowledge;Mediating;Mediator;migration;Molecular;mosaic;Mus;Muscle Cells;Myofibroblast;nephrogenesis;netrin receptor;new therapeutic target;novel;novel therapeutics;NTN1 gene;Organ failure;paracrine;Paracrine Communication;Pathogenicity;Pericytes;Population;Prevalence;Process;Production;progenitor;Proteins;receptor;receptor expression;Receptor Inhibition;recruit;Regenerative Medicine;Regulation;Reporter;response;Role;Secondary to;Small Interfering RNA;Smooth Muscle;Smooth Muscle Myocytes;Source;spatiotemporal;Stains;stromal progenitor;targeted treatment;Techniques;Testing;Therapeutic Intervention;Time;tool;Toxin;Transplantation;United States;Vascular Smooth Muscle

PROJECT_TITLE: The role and regulation of pericytes in remodeling the periarterial niche during nephrogenesis


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Clinical Research;Precision Medicine;Rheumatoid Arthritis

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: Study Title: Type I Interferon Impacts Treatment Response in Rheumatoid Arthritis PROJECT NARRATIVE Insufficient treatment in rheumatoid arthritis (RA) results in increased morbidity and mortality, and a heavy economic burden associated with loss of function. This research will help to develop a more individualized approach to therapy in RA and determine an immunologic basis of non-response to TNF inhibitors. The findings could suggest a molecular rationale for the use of specific therapies in biologically defined subgroups of patients.

PI_NAMEs: WAMPLER MUSKARDIN, THERESA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Affect;Architecture;Artificial Intelligence;Basic Science;Biological;Biological Assay;Biological Response Modifier Therapy;Biology;Biomedical Engineering;Biopsy;Biopsy Specimen;Blood;Caliber;career;cell type;Cells;Cellular biology;Clinical Research;clinically significant;Coculture Techniques;cohort;Complement;CSF1R gene;Cues;cytokine;Data;density;digital;Disease;Disease remission;Dissection;Economic Burden;effective therapy;Effector Cell;empowerment;Environment;experimental study;Fibroblasts;Flow Cytometry;Fortification;Future;Gene Expression;Gene Expression Profiling;Genes;Grant;Histology;Histopathology;Human;immune cell infiltrate;Immunologics;Immunology;In Vitro;Individual;ineffective therapies;Infiltration;Inflammatory;Infrastructure;inhibitor;inhibitor therapy;Interferon alpha;Interferon Type I;Interferon-beta;Interferons;Invaded;Investments;JAK1 gene;Lasers;loss of function;Macrophage;Mass Spectrum Analysis;Measures;Mediator;microphysiology system;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;novel;organ on a chip;Osteoclasts;partial response;Pathology;Pathway interactions;patient subsets;Patients;Pattern;peripheral blood;personalized approach;Phenotype;Population;precision medicine;prevent;Production;prognostication;Proteins;Proteomics;Publishing;Research;Research Personnel;Resources;response;Rheumatoid Arthritis;Sampling;Scientist;Serum;Signal Transduction;single cell analysis;skills;Specificity;Stimulus;Stromal Cells;Synovial Cell;Synovial Membrane;System;Testing;Time;Tissues;TNF gene;Translational Research;treatment response;treatment strategy;tumor necrosis factor-alpha inhibitor;Validation;Vascularization;Work

PROJECT_TITLE: Type I interferon Impacts Treatment Response in Rheumatoid Arthritis

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE A key objective in efforts to reduce cancer health disparities is standardizing access to care. This proposal aims to develop a novel physician network-based measure characterizing access to specialist cancer care and investigate how this knowledge can be used to reduce rural, racial, and socioeconomic disparities in patient outcomes for breast, colorectal, and lung cancer patients. We will use these results to bridge theory and practice by developing a data-driven algorithm that would deliver to health systems approaches for establishing more robust physician networks and improve patient outcomes.

PI_NAMEs: MOEN, ERIKA  (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: access disparities;Address;Administrator;Algorithms;Area;Attention;barrier to care;cancer care;cancer health disparity;Cancer health equity;Cancer Patient;cancer therapy;care delivery;care providers;Caring;Centers for Disease Control and Prevention (U.S.);Characteristics;Cities;Clinical;Colorectal Cancer;Communities;Data;Development;Disparity;disparity reduction;Equity;General Practitioners;Geography;Goals;Health Policy;Health Services Accessibility;Health system;Healthcare;Improve Access;improved;improved outcome;Incidence;Individual;informant;innovation;insight;Intervention;Interview;Knowledge;Link;Location;low socioeconomic status;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medical Oncology;medical specialties;Medicare;Medicare claim;Modeling;models and simulation;mortality;Network-based;novel;Oncologist;Oncology;Operative Surgical Procedures;Outcome;Output;outreach;Pathway Analysis;patient oriented;Patient-Focused Outcomes;Patients;Pattern;Perception;Physicians;Policies;Quality of Care;Race;racial disparity;racial minority;Radiation;recruit;Reporting;Resource Allocation;Retrospective cohort study;Rural;rural area;rural disparities;Rural Hospitals;rural patients;rurality;Services;simulation;socioeconomic disparity;Socioeconomic Status;socioeconomics;Specialist;Standardization;Structure;teleoncology;Testing;theories;Travel;underserved area;urban disparity;Variant;Work

PROJECT_TITLE: Improving cancer health equity by targeting physician networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Z(02)]


NIH_SPENDING_CATS: Kidney Disease;Lymphatic Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Acute Kidney Injury (AKI) is a serious clinical problem that affects ~20% of hospitalized patients and 60% of critically ill patients while increasing risk of developing chronic kidney disease. The overall goal of this project is to understand cellular and molecular mechanisms that govern how lymphatic and blood endothelial cells in the kidney respond to injury and impact AKI pathogenesis. Understanding the response of the kidney endothelial subpopulations to injury in relation to other cell types in the kidney will have a significant impact on our ability to design novel, targeted therapies for AKI.

PI_NAMEs: GHAJAR-RAHIMI, GELARE  (contact)

PROJECT_TERMS: 3-Dimensional;Acute Renal Failure with Renal Papillary Necrosis;Affect;Architecture;Area;Bilateral;Binding;Bioinformatics;Blood;Blood capillaries;Blood Vessels;career;career development;cell type;Cells;Chronic Kidney Failure;Cisplatin;Clinical;clinical application;clinical care;Clinical Trials;Coculture Techniques;Cohort Studies;Communication;Complication;Critical Illness;Cytometry;Data;Death Rate;density;design;Development;Dialysis procedure;Disease;Doctor of Philosophy;doctoral student;Economic Burden;End stage renal failure;Endothelial Cells;Endothelium;Epithelial Cells;Evaluation;experience;experimental study;Familiarity;Fluid Balance;Foundations;Functional disorder;Future;Genetic Transcription;Glomerular Filtration Rate;Goals;Grant;Health;Homeostasis;Hospitalization;Hypoxia;Image;Immune;Impairment;improved;improved outcome;In Vitro;in vivo;Incidence;Inflammation;injured;Injury;Injury to Kidney;insight;Intensive Care Units;Intervention;Ischemia;ischemic injury;Kidney;Kidney Diseases;Link;Literature;Lymphangiogenesis;Lymphatic;Lymphatic Endothelial Cells;Lymphatic Endothelium;lymphatic vasculature;lymphatic vessel;Macrophage;Manuscripts;Maps;Mediator;Mentors;Microscopy;Modeling;Molecular;Molecular Biology;Morbidity - disease rate;mortality;Mus;Myelogenous;Natural regeneration;new therapeutic target;next generation sequencing;NF-kappa B;novel;Optics;Oxygen;Pathogenesis;Patients;PECAM1 gene;Physicians;Population;prevent;Process;progenitor;Protocols documentation;Publishing;receptor;Regulation;renal damage;Renal function;Reperfusion Injury;Reperfusion Therapy;Reporter;Research;research and development;response;response to injury;responsible research conduct;Risk;Role;Scientist;Signal Transduction;skill acquisition;skills;stem cell population;success;Supportive care;System;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Studies;Time;Tissues;trafficking;Training;transcription factor;transcriptomics;Translational Research;Tubular formation;United States;United States National Institutes of Health;Validation;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factor D;Vascular Endothelial Growth Factor Receptor-3;Vascular Endothelial Growth Factors;Vascular remodeling;Vascular System;Work;Writing

PROJECT_TITLE: Regulation of Lymphatic and Vascular Remodeling in Acute Kidney Injury


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The persistent threat to health posed by infectious diseases mandates that the United States continue to train a diverse and sophisticated cadre of biomedical investigators with the research and clinical skills necessary to develop and implement new strategies to diagnose, prevent and treat them. This NRSA has successfully accomplished these training objectives and holds great promise to continue along this vital path.

PI_NAMEs: GIORDANO, THOMAS P (contact);MYSOREKAR, INDIRA U

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Immunity;Infection;Research Training

PROJECT_TITLE: Research Training in Infection and Immunity

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Rare Diseases;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE While immunotherapy for oral cancers has shown some dramatic results, it benefits only a minority of patients. Therefore, there is an unmet medical need to better understand how oral cancers and other solid tumors suppress the immune system and to learn how to effect better immunologic outcomes. This project, which has important implications for environmental science, immunotoxicology, and immunotherapy, will take novel approaches to determine how a cellular receptor that recognizes environmental pollutants and is associated with the development of oral cancers (the aryl hydrocarbon receptor) contributes to suppression of otherwise effective anti- tumor immune responses.

PI_NAMEs: SHERR, DAVID H (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Address;Affect;Aggressive behavior;Agonist;Alcohols;anti-tumor immune response;antigen-specific T cells;Aryl Hydrocarbon Receptor;bean;Biological Response Modifiers;Biology;Cancer Biology;cancer cell;Cancer Model;carcinogenesis;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Transplantation;Cells;cellular targeting;chemotherapy;Chemotherapy and/or radiation;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;combustion product;CRISPR/Cas technology;CTLA4 gene;Cytometry;Data;Dendritic Cells;Development;Diagnosis;draining lymph node;effector T cell;environment related cancer;environmental chemical;Environmental Pollutants;Environmental Science;Etiology;exhaustion;exposure to cigarette smoke;Gene Deletion;Generations;Genes;Genetic Complementation Test;Goals;granulocyte;Head and Neck Squamous Cell Carcinoma;Human Papillomavirus;Image;Immune;immune checkpoint;Immune system;Immunity;Immunologic Receptors;Immunologics;Immunology;immunoregulation;Immunosuppression;Immunotherapy;Immunotoxicology;improved;In complete remission;inhibitor;innovation;Interferon Type II;Knock-out;Knockout Mice;Kynurenine;Lead;Learning;Left;Ligands;Location;Macrophage;malignant mouth neoplasm;Malignant Neoplasms;Maps;Mediating;Mediator;Medical;microbial;Minority;Modeling;Morbidity - disease rate;mouse model;mouth squamous cell carcinoma;Mus;nano-string;novel;novel strategies;Operative Surgical Procedures;oral immunotherapy;Outcome;Pathway interactions;patient prognosis;Patients;Persons;Play;Pre-Clinical Model;Production;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Publishing;Radiation therapy;receptor;Receptor Activation;receptor expression;Receptor Inhibition;Refractory;Research Design;Resolution;response;Role;single-cell RNA sequencing;Solid Neoplasm;spatial relationship;Survival Rate;T-Lymphocyte;Testing;Tobacco smoke;Transplantation;Tryptophan;Tryptophan 2,3 Dioxygenase;tumor;Tumor Antigens;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor-infiltrating immune cells;Work;Xenobiotics

PROJECT_TITLE: An Environmental Chemical Receptor, the AhR, as a Mediator of Multiple Immune Checkpoints in Oral Cancer

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]