ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Technology in current small animal radiation research (SARR) has significantly lagged behind that in human radiotherapy (RT), impairing SARR study relevance to human RT, impeding explorations in RT research, and hindering rapid conduction of SARR studies. This project will develop a next-generation SARR platform with novel imaging, planning, delivery, and computation techniques to fill this critical void between SARR and human RT. The developed system will become an essential component in preclinical research for the exploration of novel radiotherapeutic strategies with high relevance to human RT.

PI_NAMEs: JIA, XUN  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Address;Algorithms;anatomic imaging;Anesthesia procedures;Animals;Clinic;Clinical;Clinical Treatment;Collimator;Communities;Computational Technique;Computer software;cone-beam computed tomography;cost;Cost Analysis;Dedications;design;design and construction;Development;Development Plans;Disparity;Dose;Engineering;Ensure;evidence base;experience;Freedom;frontier;Functional Imaging;Generations;Hour;Human;Hypoglycemia;Image;image guided;imaging modality;imaging platform;Immune response;Impairment;improved;industry partner;innovation;Intensity-Modulated Radiotherapy;Interruption;Intuition;Investigation;Joints;Learning;Lung;Malignant Neoplasms;Manuals;Mechanics;Medical;Medical center;Modality;Modernization;natural hypothermia;new technology;next generation;Normal tissue morphology;novel;Organ;Physiological;Positron-Emission Tomography;pre-clinical;pre-clinical research;preclinical study;Price;Process;product development;prototype;Radiation;Radiation Dose Unit;Radiation therapy;Radiobiology;Radiotherapy Research;Rattus;reconstruction;Reliability of Results;Research;research study;Resources;response;Risk;Sales;Sample Size;Shapes;Side;Software Design;Speed;System;systems research;Techniques;Technology;Testing;Therapeutic;Time;Tissues;Translating;Translations;treatment planning;treatment response;tumor;Validation

PROJECT_TITLE: Next generation small animal radiation research platform

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-SBIB-Q(57)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: LUBBOCK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

ORG_STATE: TX

PHR: Project Narrative In order to continually grow, cancer cells need to maintain telomeres which if not maintained by some form of telomere maintenance mechanism (TMM) done by telomerase, an enzyme that adds telomeric repeats to the ends of chromosomes or by the alternative lengthening of telomeres (ALT) mechanism. This project will define parameters that impact on two assays needed to define cancer TMM as prognostic markers and companion diagnostics for novel drugs: TERT mRNA expression qPCR and the unique PCR assay for telomeric DNA C-circles, which provides a specific marker for ALT cancers. We will also develop an assay to detect C-circles in patient blood samples and complete regulatory steps needed for clinical implementation of these assays.

PI_NAMEs: REYNOLDS, CHARLES PATRICK (contact)

PROGRAM_OFFICER_NAME: RAO, ABHI

PROJECT_TERMS: Adult;Affect;Anticoagulants;ataxia telangiectasia mutated protein;ATM activation;ATRX gene;Biological;Biological Assay;Biological Markers;Biology;Biopsy;Blood;Blood specimen;Bone Marrow;Bone Marrow Aspiration;cancer biomarkers;cancer cell;cancer classification;cancer type;Catalytic Domain;cell free DNA;Cells;chemotherapy;Child;Chromosomes;Classification;CLIA certified;Clinical;clinical application;clinical implementation;clinical risk;Clinical Trials;Code;cohort;Collection;companion diagnostics;Data;DAXX gene;Detection;diagnostic assay;DNA;DNA Damage;Drug Targeting;Enzymes;Fixatives;Genetic Recombination;Heparin;Human;improved;inhibitor;Laboratories;Malignant Childhood Neoplasm;Malignant Neoplasms;Marrow;Messenger RNA;Modeling;molecular pathology;mRNA Expression;Mutation;Neoplasm Metastasis;neoplastic cell;Neuroblastoma;new therapeutic target;novel;novel strategies;novel therapeutics;Nucleic Acids;Nucleoproteins;Outcome;participant enrollment;Patient risk;Patients;Pediatric Oncology Group;peripheral blood;Phase III Clinical Trials;Phenotype;Plasma;Prevalence;Process;Prognosis;prognostic;Prognostic Marker;Proliferating;Protocols documentation;Quality Control;Quantitative Reverse Transcriptase PCR;Research;Resistance;Reverse Transcriptase Polymerase Chain Reaction;Ribonucleoproteins;risk stratification;RNA;sample collection;Sampling;Selection for Treatments;Sensitivity and Specificity;Solid Neoplasm;Source;success;targeted treatment;Telomerase;telomere;Telomere Maintenance;Temperature;TERC gene;TERT gene;Therapeutic Clinical Trial;Time;Tissues;TP53 gene;Translating;Tube;tumor;Tumor Burden;tumor DNA;Tumor Tissue

PROJECT_TITLE: Robust assays to define telomere maintenance mechanisms as cancer biomarkers.


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Patient Safety;Pediatric;Precision Medicine;Rare Diseases;Sickle Cell Disease

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Sickle cell anemia is an inherited blood disorder that affects millions of children across the world, mostly in sub- Saharan Africa, who will suffer from serious complications, including death, if treatment is not available. Hydroxyurea, a once daily oral medication has been shown to improve most symptoms and reduce mortality for children and adults with sickle cell anemia but is rarely used in many limited-resource settings due in part to concerns about appropriate dosing and monitoring. The primary objectives of this research study are to establish the feasibility and evaluate the clinical benefits of personalized hydroxyurea dosing and to evaluate the safety of hydroxyurea use with limited laboratory monitoring for children with sickle cell anemia living in Angola and Tanzania to provide evidence that will allow for expanded access to this lifesaving medication.

PI_NAMEs: MCGANN, PATRICK THOMAS (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: 2 year old;5 year old;Address;Adult;Adverse event;Affect;Africa;Africa South of the Sahara;African;Algorithms;Angola;appropriate dose;arm;Blood;Caring;Cessation of life;Child;Child Mortality;Childhood;Clinical;clinical research site;Clinical Trials;clinically significant;Computers;Country;Development;Dose;dose individualization;Drug Kinetics;Early Diagnosis;experience;Family;Fetal Hemoglobin;Frequencies;health related quality of life;Hematological Disease;Hematology;High Pressure Liquid Chromatography;hydroxyurea;improved;Infant;Inherited;interpatient variability;Knowledge;Laboratories;Life;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Monitor;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Newborn Infant;novel;novel therapeutics;open label;Oral;Participant;participant enrollment;Patients;Pharmaceutical Preparations;Phase;Placebos;precision medicine;prevent;prospective;Quality of life;randomized, clinical trials;research study;Resource-limited setting;Resources;Running;Safety;safety and feasibility;Sickle Cell;Sickle Cell Anemia;sickling;standard of care;Symptoms;Tanzania;Therapeutic;Toxic effect;treatment strategy;Weight

PROJECT_TITLE: Promoting Utilization and Safety of Hydroxyurea Using Precision in Africa


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE This Cancer Center Support Grant is requested to provide support for the critical infrastructure and shared  resources needed by Lurie Cancer Center investigators to develop approaches and methods for cancer prevention, treatment and control.

PI_NAMEs: PLATANIAS, LEONIDAS C. (contact)

PROGRAM_OFFICER_NAME: PTAK, KRZYSZTOF

PROJECT_TERMS: Address;anti-cancer research;Basic Science;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer prevention;Catchment Area;Chicago;Clinical;clinical application;Clinical Investigator;Clinical Research;Clinical Sciences;Communities;Community Outreach;Community Physician;Comprehensive Cancer Center;Dedications;Educational Activities;Faculty;Funding;Goals;Growth;Hospitals;Illinois;Infrastructure;innovation;Institution;International;Investments;Knowledge;Laboratories;Leadership;Malignant Neoplasms;Medical;medical schools;Medicine;member;Methods;Mission;multidisciplinary;next generation;Organization administrative structures;patient oriented;Population;Population Research;Population Sciences;Precision Medicine Initiative;precision oncology;Prevention;Process;programs;recruit;Research;Research Activity;Research Personnel;Resource Sharing;Resources;Schools;Scientist;Site;Strategic Planning;survivorship;Training;Translating;Translational Research;Translations;Underserved Population;Universities

PROJECT_TITLE: The Robert H. Lurie Comprehensive Cancer Center


NIH_SPENDING_CATS: Cancer

PI_NAMEs: ZAFIROVSKI, ALEKSANDAR  (contact)

PROJECT_TERMS: Agreement;Award;Basic Science;Budgets;cancer care;Cancer Center;Cancer Center Support Grant;Caring;Catchment Area;Chicago;clinical care;Clinical Research;Clinical Sciences;Collaborations;Communication;Community Outreach;Comprehensive Cancer Center;Dedications;design;Development;Electronic Mail;Ensure;Evaluation;Faculty;Faculty Recruitment;faculty support;Fostering;Funding;Funding Opportunities;Goals;Grant;Hospitals;Information Technology;Institution;Knowledge;Leadership;Medical;medical schools;Medicine;meetings;member;Mission;Monitor;multidisciplinary;NCI Center for Cancer Research;Newsletter;Office of Administrative Management;Outcome;patient oriented;Performance;Persons;Philanthropic Fund;Pilot Projects;Play;Policies;Population Sciences;Process;Productivity;programs;Publications;recruit;Report (document);Research;Research Personnel;Resource Sharing;Resources;satisfaction;Schools;Science;Services;Site Visit;Strategic Planning;survivorship;Translational Research;Translations;Universities;web site;Work

PROJECT_TITLE: Cancer Center Administration


PI_NAMEs: BONINI, MARCELO G. (contact)

PROJECT_TERMS: anti-cancer research;Area;Award;Cancer Biology;Cancer Center;career;career development;Caregivers;Catchment Area;Chicago;Clinical;clinical development;Clinical Sciences;clinically relevant;Collaborations;Communication;Communities;Comprehensive Cancer Center;Dedications;doctoral student;Education;Educational Activities;Environment;Faculty;Funding;Future;Grant;Health Professional;Healthcare;International;Journals;Laboratories;lectures;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Molecular;novel;Oncologist;Oncology;Oncology Nurse;outreach;Participant;Population Sciences;Postdoctoral Fellow;posters;precision medicine;Prize;Professional Education;programs;Research;Research Personnel;Scientist;Series;Special Event;Students;symposium;Training;Training and Education;training opportunity;translational oncology;Travel;tumor;undergraduate education;undergraduate student;United States National Institutes of Health

PROJECT_TITLE: Cancer Research Career Enhancement andRelated Activities


PI_NAMEs: ARVANITIS, CONSTADINA  (contact)

PROJECT_TERMS: 3-Dimensional;Applications Grants;Award;base;Calcium;Cancer Biology;Cancer Center;cell fixing;Cells;Comprehensive Cancer Center;Computer software;Conceptions;Confocal Microscopy;Core Facility;Data;Data Analyses;data exchange;data management;Data Storage and Retrieval;Decentralization;Dedications;Education;Education and Outreach;Educational workshop;Electron Microscope;Electron Microscopy;Equipment;Fluorescence;Fluorescence Resonance Energy Transfer;Funding;Hour;Image;Image Analysis;imaging approach;imaging facilities;imaging system;Imaging Techniques;Imaging technology;improved;instrument;instrumentation;Investigation;Journals;Leadership;Light;light microscopy;live cell imaging;luminescence;Manuscripts;member;Microscope;Microscopy;model organism;novel imaging technology;Organ;Phase;Platinum;Plug-in;Preparation;programs;Reagent;Research;Research Personnel;Resource Sharing;Resources;routine imaging;Scanning;Secure;Services;single molecule;Slice;Source;Specialist;success;System;Techniques;Technology;technology platform;Testing;Tissue imaging;Tissues;Training;ultra high resolution;United States;Universities;Whole Organism

PROJECT_TITLE: Center for Advanced Microscopy Shared Resource


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Rehabilitation

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Patients with ischemic left ventricular (LV) dysfunction commonly undergo coronary revascularization as a strategy to improve contractile function, but response varies and is poorly predicted by conventional imaging approaches to identify salvageable (“viable”) myocardium. It is unknown if impact of revascularization on contractile recovery varies based on hypoperfusion, if non-ischemic substrate modifies revascularization response, and if contractile recovery parallels improved clinical prognosis. This study will leverage a new multicenter trial (STICH-3C) to test utility of multiparametric cardiac MRI - including perfusion, non-ischemic subtrate, and infarct imaging using a new black blood MRI approach - for prediction of LV response to revascularization, so as to enhance decision-making and improve clinical outcomes for millions of patients with ischemic heart disease.

PI_NAMEs: GAUDINO, MARIO FL (contact);WEINSAFT, JONATHAN W.

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Address;Adult;American;Area;Blood;Blood flow;Cardiac;cardiac magnetic resonance imaging;Cardiac Surgery procedures;Cessation of life;Clinical;clinical decision-making;clinical prognosis;Clinical Trials;Collaborations;Coronary;Coronary Arteriosclerosis;Coronary Vessels;Darkness;Data;Decision Making;efficacy testing;EFRAC;Enrollment;Equipoise;Event;extracellular;Functional disorder;functional outcomes;Funding;Gadolinium;Health;Heart failure;Heterogeneity;hospital readmission;Hospitalization;hypoperfusion;Image;Image Enhancement;imaging approach;Impairment;improved;Infarction;Infrastructure;insight;Ischemia;Knowledge;Left;Left Ventricular Dysfunction;Left Ventricular Ejection Fraction;Left Ventricular Function;Magnetic Resonance;Magnetic Resonance Imaging;Medical;member;mortality;Multicenter Trials;Myocardial Ischemia;Myocardial tissue;Myocardium;novel;Observational Study;Operative Surgical Procedures;Outcome;outcome prediction;Pathology;Patients;Perfusion;Phenotype;Physiological;Population;Prediction of Response to Therapy;Productivity;Prognosis;prognostic assays;Property;prospective;Quality of life;Recovery;Recovery of Function;Research;Residual state;Resolution;response;restoration;revascularization;Risk;risk stratification;Role;Site;stem;Stroke;Technology;Testing;Therapeutic;Time;Tissues;tool;treatment effect;trial comparing;Uncertainty;Ventricular

PROJECT_TITLE: Cardiac Magnetic Resonance Tissue Characterization of Ischemic and Non-Ischemic Myocardium to Predict Left Ventricular Functional Recovery and Outcomes after Multivessel Coronary Revascularization

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


PI_NAMEs: JAMES, CHARLES DAVID (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adherent Culture;analytical tool;Animals;Apoptotic;Applications Grants;Area;Biological;Biological Assay;Cancer Center;Cancer Center Support Grant;Cancer Model;Cancer Patient;cancer subtypes;cancer therapy;cancer type;Cell Line;Cellular Assay;chemotherapy;Client;clinical translation;Clinical Trials;Comprehensive Cancer Center;Consumption;cost;Data;Developmental Therapeutics Program;discount;Drug Formulations;Drug Kinetics;Drug Stability;Engraftment;Evaluation;exome sequencing;Faculty;first-in-human;Goals;Grant;Human;IACUC;Image;Immune response;Immune system;immune system function;Immunocompetent;immunocytochemistry;Immunologics;Immunotherapy;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;interest;Invaded;Legal patent;Libraries;Malignant Neoplasms;Manuscripts;member;migration;model development;Modeling;Modification;Molecular;Molecular Profiling;mouse model;Mus;neoplastic cell;novel;novel therapeutics;operation;Operative Surgical Procedures;Organoids;patient derived xenograft model;Patients;Peer Review;Pharmaceutical Preparations;Preclinical Testing;Preparation;Process;Proliferating;Protocols documentation;Publications;repository;Research;Research Activity;Research Design;Research Personnel;Resource Sharing;response;Route;screening;Services;spheroids;Study models;subcutaneous;targeted treatment;Testing;testing services;Therapeutic;therapeutic candidate;Therapeutic Effect;therapeutic evaluation;Therapeutic Intervention;three dimensional cell culture;Time;Toxicology;Training;transcriptome;transcriptome sequencing;Translation Initiation;translational cancer research;translational impact;Translational Research;treatment effect;Treatment Efficacy;treatment response;tumor;Tumor Cell Line;tumor growth;tumor immunology;uptake;Xenograft procedure

PROJECT_TITLE: Developmental Therapeutics Core Shared Resource


NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: PERLMAN, HARRIS R (contact)

PROJECT_TERMS: Adoptive Cell Transfers;antigen detection;assay development;Basic Science;Biological Assay;Biological Sciences;Cancer Center;cell analyzer;Cell Cycle;Cell Separation;Cells;Chicago;Clinical Research;Collaborations;Color;Communities;Complex;Comprehensive Cancer Center;Computer software;Consultations;Core Facility;cost efficient;Cytometry;Data;data acquisition;Data Analyses;Development;Education;Epitopes;Equipment;experience;Experimental Designs;Flow Cytometry;Fostering;Generations;Heterogeneity;Hour;Human Resources;Individual;instrument;instrumentation;interest;Lasers;Malignant Neoplasms;Measurement;member;Mission;Molecular Analysis;new technology;operation;particle;Performance;Phenotype;Phosphoproteins;Phosphorylation;Population;Preparation;Principal Investigator;Procedures;programs;protocol development;Protocols documentation;Research;Research Personnel;Resource Sharing;Sampling;Services;Sorting;Technical Expertise;Training;Training Programs;Translational Research;Universities;Validation;web site

PROJECT_TITLE: Flow Cytometry Core Shared Resource


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PI_NAMEs: HORVATH, CURT M (contact)

PROJECT_TERMS: assay development;Biochemical;Biochemistry;Biological Assay;Cancer Biology;Cancer Center Support Grant;cell behavior;Cell Physiology;Cells;Cellular biology;Certification;Collaborations;Collection;Communities;Complex;Comprehensive Cancer Center;Computer software;Confocal Microscopy;Consultations;cost;CRISPR library;Crystallization;Data;Data Analyses;Data Collection;data management;design;Development;Developmental Therapeutics Program;Ensure;Environment;Equipment;Experimental Designs;experimental study;Future;gene function;Genes;genome-wide;Hand;high throughput analysis;high throughput screening;Human;Industry;instrument;instrumentation;interest;Laboratories;laboratory experience;lead optimization;Libraries;Liquid substance;Malignant Neoplasms;member;Miniaturization;Mission;Molecular Biology;Mus;nanolitre;new therapeutic target;novel therapeutics;Organoids;parallelization;Pharmaceutical Chemistry;Productivity;Reader;Reporting;Research;Research Personnel;Resource Sharing;Resources;Robotics;Running;Sampling;Science;screening;Services;Speed;Structural Biologist;Structure-Activity Relationship;Support Groups;System;Technical Expertise;Technology;Therapeutic Agents;tissue culture;Training;Translational Research;Validation;Work

PROJECT_TITLE: High Throughput Analysis Laboratory Shared Resource


NIH_SPENDING_CATS: Bioengineering;Cancer;Nanotechnology

PI_NAMEs: ROSENZWEIG, AMY C. (contact)

PROJECT_TERMS: Address;anti-cancer research;Artificial nanoparticles;Basic Science;Binding;Biochemical;Biological;Biological Assay;biophysical analysis;biophysical properties;Biophysics;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer therapy;Communities;Comprehensive Cancer Center;Core Facility;cost;Data;Development;Diagnosis;digital;Drug Design;drug development;Enzymes;Equipment;exosome;extracellular vesicles;Faculty;Feedback;Fostering;Gel;Genetic study;high throughput screening;Human Resources;imaging capabilities;Individual;Infrastructure;instrument;instrumentation;interdisciplinary collaboration;Interferometry;Invaded;Investments;Kinetics;Laboratories;Lead;macromolecule;Malignant Neoplasms;member;Methods;Molecular;Molecular Conformation;Molecular Structure;Molecular Target;nano-oncology;nanoparticle;NCI Center for Cancer Research;Neoplasm Metastasis;neoplasm resource;new technology;Normal Cell;novel;Nucleic Acids;Peer Review;Peptides;Pharmaceutical Preparations;Play;prevent;Principal Investigator;Process;Program Development;Proteins;Publications;Research;Research Design;Research Personnel;research study;Resource Sharing;Role;screening;Services;Signal Pathway;Signaling Protein;small molecule;Structure;Surface Plasmon Resonance;Surveys;targeted cancer therapy;Technical Expertise;Testing;Therapeutic Agents;therapeutic nanoparticles;Thermodynamics;Training;Translating;translational applications;Translational Research;Translations;tumorigenesis;Validation

PROJECT_TITLE: Keck Biophysics Facility Shared Resource


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Contraception/Reproduction;Data Science;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: RICHARDSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Our understanding in human placenta and its abnormalities is limited, because we do not have a medical imaging device to non-invasively observe the blood flow in the small vessels of human placenta in vivo. To fill this gap, we propose to build a semi-real-time ultrasound vector flow velocity imaging system using deep learning models to provide detailed and quantitative imaging of the flow velocity magnitudes and flow directions in human placenta. The successful completion of the project will provide a novel ultrasound imaging technology for the scientific investigation and early clinical assessment of placental development and abnormalities.

PI_NAMEs: LI, YOU  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Acoustics;Affect;Artificial Intelligence;Biology;Biomedical Engineering;Blood;Blood flow;career;career development;Chorionic villi;Clinic;Clinical;Clinical assessments;Clinical Research;cohort;Complex;Data;Data Science;deep learning;deep learning model;deep neural network;design;Development;Diameter;Discipline of obstetrics;Disease;Doppler Ultrasound;early pregnancy;Faculty;fetal;Fetal Growth Retardation;Fetus;Future;Growth;Gynecology;hemodynamics;Human;Human Development;human imaging;Image;Imaging Device;imaging modality;imaging system;Imaging Techniques;Imaging technology;in vivo;Investigation;Knowledge;Late pregnancy;Lateral;Machine Learning;machine learning model;Manuals;Maternal Mortality;Measurement;Measures;Medical Imaging;Mentors;Methodology;millimeter;Modeling;Monitor;Mothers;multidisciplinary;Network-based;neural network;neural network architecture;Neural Network Simulation;new technology;Noise;novel;Output;parallelization;Pattern;Physiological;Placenta;Placenta Accreta;Placenta Diseases;Placental Insufficiency;Placentation;Play;Pre-Eclampsia;Pregnancy;Pregnant Women;Premature Labor;Program Development;programs;quantitative imaging;Radiology Specialty;Research;research and development;Research Personnel;Resolution;Role;simulation;skill acquisition;skills;Spiral Artery of the Endometrium;Structure;System;technique development;Techniques;Technology;tenure track;Testing;Time;Tissues;tool;Training;training data;Translating;Translational Research;transmission process;Trees;Ultrasonic wave;Ultrasonography;ultrasound;Uncertainty;United States;Universities;vector;Villous;Virginia;Visualization

PROJECT_TITLE: Vector Flow Velocity Imaging of Human Placenta using Angle-resolved Ultrasound and Deep Learning

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: SCHEIDT, KARL A (contact)

PROJECT_TERMS: Address;analog;Animal Model;Antineoplastic Agents;Applications Grants;Basic Science;Biological;biological systems;Biology;Cancer Biology;Cancer Center;candidate selection;Cells;chemical synthesis;Chemicals;cheminformatics;Chemistry;clinical candidate;Clinical Research;Collaborations;Comprehensive Cancer Center;computational chemistry;Computer Assisted;Consult;Core Facility;Custom;design;Development;Developmental Therapeutics Program;Doctor of Philosophy;Drug Design;drug development;drug discovery;Environment;Equipment;experience;forging;Funding;Goals;high throughput analysis;high throughput screening;in silico;Industry;insight;Interdisciplinary Study;Laboratories;Lead;lead optimization;Ligands;Malignant Neoplasms;Medicine;member;Modern Medicine;Molecular Medicine;molecular modeling;Molecular Probes;Movement;novel therapeutics;Pharmaceutical Chemistry;Pharmacologic Substance;Process;programs;Proteins;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;Scientist;screening;Service delivery model;Services;skills;small molecule;success;Synthesis Chemistry;Techniques;Technology;Testing;Therapeutic;tool;Translating;Translational Research;translational research program;Translations;Universities;Visualization;Work

PROJECT_TITLE: Medicinal and Synthetic Chemistry Core Facility Shared Resource


PI_NAMEs: KIM, DONG-HYUN  (contact)

PROJECT_TERMS: Animal Model;anti-cancer research;Antineoplastic Agents;Biological Sciences;Cancer Center;Cancer Center Support Grant;cell behavior;Cells;Chicago;Clinical;clinical imaging;Clinical Research;Collaborations;Comprehensive Cancer Center;Computer software;Core Facility;data analysis pipeline;Development;Developmental Therapeutics Program;efficacy evaluation;Engraftment;Equipment;Flow Cytometry;Funding;Goals;Grant;Histologic;Histology;Image;Image Analysis;image processing;image translation;imaging approach;imaging capabilities;imaging modality;imaging study;Imaging technology;improved;in vivo;Individual;instrumentation;Isotope Labeling;Label;Magnetic Resonance Imaging;Malignant Neoplasms;Medical Imaging;member;Methods;Modality;Molecular;Multimodal Imaging;Mus;Near-infrared optical imaging;Neoplasm Metastasis;non-invasive monitor;novel diagnostics;novel strategies;novel therapeutics;nuclear imaging;Outcome Study;Patient Care;Peer Review;PET/CT scan;Phenotype;pre-clinical;preclinical imaging;preclinical study;Production;Radiochemistry;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Schedule;Services;single photon emission computed tomography;Site;Sorting;Technology;Testing;Therapeutic Agents;tool;tumor growth;Universities;Validation;Work

PROJECT_TITLE: Molecular and Translational Imaging Core Facility Shared Resource


PI_NAMEs: YANG, GUANG-YU  (contact)

PROJECT_TERMS: angiogenesis;Animal Cancer Model;Animal Experimentation;Animal Experiments;Animal Model;animal tissue;Animals;anti-cancer research;Antibodies;Apoptosis;Autopsy;Biological;Biological Models;Board Certification;Caliber;Cancer Biology;Cancer Center;Cancer Center Support Grant;Communities;Complex;Comprehensive Cancer Center;Consult;cost;Development;Disease;Embryo;Evaluation;experience;Experimental Designs;experimental study;Feedback;Formalin;Freezing;Funding;Hematoxylin and Eosin Staining Method;Histologic;histological stains;Histology;Histopathology;human tissue;Immunofluorescence Immunologic;Immunohistochemistry;improved;in vivo Model;Inflammatory Infiltrate;insight;investigator training;Laboratories;Laboratory mice;Learning;member;Microscopic;Mission;Mitosis;Morphology;mouse model;Mus;NCI Center for Cancer Research;Necrosis;Neoplasm Metastasis;operation;Organ;Paraffin Embedding;Pathologist;Pathology;Peer Review;Phenotype;Postdoctoral Fellow;Prevention;programs;Publications;Research;Research Design;research faculty;Research Personnel;Resource Sharing;Rodent;Services;skills;Stains;Students;Substance administration;Surveys;Techniques;Tissue Embedding;tissue processing;Tissues;Toxic effect;Toxicology;Training;training opportunity;Treatment Efficacy;tumor;Tumor Tissue;Universities;Work

PROJECT_TITLE: Mouse Histology and Phenotyping Laboratory Shared Resource


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Health Services

PI_NAMEs: BUTT, ZEESHAN AHMAD (contact)

PROJECT_TERMS: Address;Adult;Area;Attention;Attitude;Cancer Center;cancer clinical trial;Characteristics;Child;Clinic;Clinical Cancer Center;Clinical Research;Clinical Trials;Cognitive;Collaborations;Communities;community based participatory research;community based research;community setting;Comparative Effectiveness Research;Comprehensive Cancer Center;Computers;Consult;Consultations;Core Facility;Data Collection;Data Reporting;Data Science Core;Development;efficacy evaluation;Ensure;Evaluation;experience;Funding;Goals;Health behavior;Health Services Research;Human Resources;improved;information gathering;instrument;interest;Intervention Studies;Knowledge;Language;life span;literacy;Malignant Neoplasms;Measurement;member;Methods;Minority Groups;Minority Recruitment;Mission;NCI Center for Cancer Research;novel therapeutics;Observational Study;Oncology;Outcome;Outcomes Research;Participant;Patient Outcomes Assessments;Patient Recruitments;Patient Self-Report;Patients;Play;Population Heterogeneity;Population Sciences;preference;programs;Protocols documentation;Psychometrics;Qualitative Research;Questionnaires;Recommendation;recruit;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;research study;Research Support;Resource Sharing;Resources;Role;Sampling;Science;Services;skills;sociodemographics;Survey Methodology;Surveys;Symptoms;tool;Vulnerable Populations;Work

PROJECT_TITLE: Outcomes Measurement and Survey Core Facility Shared Resource


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Diabetes;Infectious Diseases;Nanotechnology;Orphan Drug;Rare Diseases;Regenerative Medicine

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Patients with diabetes are at increased risk of developing osteomyelitis or severe chronic bone infection, a debilitating condition characterized by bone loss often resulting in amputations, which poses a significant health burden. Current medical approaches for treating diabetic bone infection (osteomyelitis) are limited by (a) biofilm formation, (b) development of bacterial resistance, and (c) use of nondegradable antibiotic-delivering bone cements, which require additional removal surgery and show potential toxicity. To solve this important problem, we aim to develop an innovative drug-device combination based on rational engineering of the next-generation antibiotic that can retard resistance and an injectable nanostructured bone cement that can effectively deliver antibiotics, gradually degrade, and regenerate bone tissue.

PI_NAMEs: JANG, HAE LIN ;SENGUPTA, SHILADITYA  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Address;American;Amputation;angiogenesis;Anti-Bacterial Agents;antibiotic design;Antibiotics;Area;Bacteria;Bacterial DNA;bacterial resistance;bactericide;Binding;Binding Sites;Biochemistry;biomaterial compatibility;Biomedical Engineering;bone;Bone Cements;bone loss;Bone Regeneration;Bone Tissue;Cementation;Chemicals;Chronic;chronic infection;Clinical;Computer-Aided Design;Data;Debridement;Defect;Derivation procedure;Development;Devices;Diabetes Mellitus;diabetic;Diabetic Foot;diabetic patient;diabetic rat;Disease;Divalent Cations;DNA Gyrase;drug release profile;Drug resistance;Effectiveness;efficacy testing;Electrons;Engineering;Evolution;Excision;Experimental Designs;Formulation;Goals;Health;Heel;Hospitals;Human;Hydroxyapatites;Impairment;Implant;improved;in silico;In Vitro;in vivo;in vivo Model;Incidence;Infection;Injectable;innovation;Local Therapy;Maintenance;mechanical properties;Medical;Methods;Microbial Biofilms;Minerals;Modeling;monomer;Mutate;nanoparticle;Nanostructures;Natural regeneration;Nature;Necrosis;next generation;novel;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Osteogenesis;Osteomyelitis;Outcome;Pain;Patient Admission;Patients;Penetration;Pharmaceutical Preparations;pharmacophore;Polymethyl Methacrylate;Population;Predisposition;Prevalence;Process;Quality of life;Quinolones;rational design;Recording of previous events;Recovery;regenerative;Regenerative capacity;Research;Resistance;Resistance development;resistant strain;Risk;screening;Site;Skeleton;Surface;synergism;System;systemic toxicity;Testing;Toxic effect;Toxicology;Treatment Efficacy;Vertebral column

PROJECT_TITLE: Nanostructured degradable bone cement for delivering novel antibiotics

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research

PI_NAMEs: WEI, JIAN-JUN  (contact)

PROJECT_TERMS: Accreditation;AIDS related cancer;American;anti-cancer research;Applications Grants;Basic Science;Benign;biobank;Biological Markers;Biological Specimen database;biomarker development;Blood;blood product;Body Fluids;cancer biomarkers;Cancer Center;CLIA certified;Clinical;clinical database;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Unit;Collaborations;Collection;college;Communities;Comprehensive Cancer Center;Consent;Consult;Contracts;Core Facility;Data;Data Science Core;Dedications;Development;Developmental Therapeutics Program;digital imaging;digital pathology;Division of Cancer Prevention;DNA;Ensure;epigenomics;Equipment and supply inventories;Evaluation;Formalin;Freezing;Fresh Tissue;Frozen Sections;Funding;Genes;genetic testing;Grant;Guidelines;Hematologic Neoplasms;Histocytochemistry;Histologic;Histology;Human;human tissue;Immunohistochemistry;Individual;Industry;Institutional Review Boards;Investigation;Laboratories;Malignant neoplasm of prostate;Malignant Neoplasms;Manuals;Manuscripts;Methods;Microarray Analysis;Mission;Molecular;Nanotechnology;NCI Center for Cancer Research;neoplastic;Normal tissue morphology;Online Systems;Organoids;Paraffin Embedding;Pathologic;Pathologist;Pathology;patient derived xenograft model;Patients;pre-clinical research;precision medicine;Preparation;Primary Neoplasm;Procedures;Process;Protocols documentation;Publications;Records;Reproducibility;Research;Research Personnel;research study;Resource Sharing;Resources;RNA;Role;Sampling;Services;Solid;Specimen;Standardization;System;Technology;therapy resistant;Tissue Microarray;Tissues;tool;Translational Research;tumor;Tumor Tissue;Work

PROJECT_TITLE: Pathology Core Facility Shared Resource


PI_NAMEs: KELLEHER, NEIL L (contact)

PROJECT_TERMS: Acetylation;Affect;Amino Acid Sequence;Amino Acids;anti-cancer research;Biological;Biological Assay;Biological Markers;biomarker identification;biomarker validation;Blood;Blood specimen;Body Fluids;Cancer Center;Cancer Center Support Grant;Cell Culture Techniques;cell type;Cells;Clinical;Clinical Trials;Comprehensive Cancer Center;Computer software;Core Facility;cost;cost effective;Data;Data Analyses;data analysis pipeline;Detection;Diagnosis;Disease;Doctor of Philosophy;drug discovery;Early Diagnosis;Emerging Technologies;Epigenetic Process;exosome;Flow Cytometry;Fluorescence-Activated Cell Sorting;Funding;Gel;Generations;Genes;glycosylation;Health Services Accessibility;histone modification;Histones;instrumentation;Label;Laboratory Personnel;liquid chromatography mass spectrometry;Malignant Neoplasms;Maps;Mass Spectrum Analysis;member;Methodology;Methods;Methylation;Mission;Mitochondria;Monitor;neoplastic cell;new therapeutic target;next generation;operation;palmitoylation;patient screening;Peptides;Pharmaceutical Preparations;Phosphorylation;Post Translational Modification Analysis;Post-Translational Protein Processing;pre-clinical;Preparation;Prognosis;protein complex;Proteins;Proteomics;Proteomics Shared Resource;Publications;Reaction;Research;Research Design;research facility;Research Personnel;Research Support;Resolution;Resource Sharing;Resources;response;Saliva;Sampling;Services;Signal Pathway;Site;Site-Directed Mutagenesis;Stable Isotope Labeling;System;Technology;technology development;Time;Tissues;Training and Education;treatment response;Ubiquitination;Universities;Urine;validation studies;Work

PROJECT_TITLE: Proteomics Core Facility Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: KOCHERGINSKY, MASHA  (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Applications Grants;Area;ATAC-seq;Basic Science;Bioinformatics;Biometry;Biostatistics Core;Biotechnology;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer health equity;Chicago;ChIP-seq;Clinical;Clinical Cancer Center;Clinical Informatics;Clinical Sciences;Clinical Trials;Complex;Comprehensive Cancer Center;Computerized Medical Record;Core Facility;Custom;Data;Data Analyses;data management;data repository;Data Science;Data Science Core;data submission;data visualization;data warehouse;Databases;design;Development;Dimensions;Discipline;Disease;Doctor of Philosophy;electronic data;Faculty;Gene Expression;Genes;Genetic;Goals;Image;Informatics;informatics infrastructure;informatics tool;Information Retrieval;Information Systems;Journals;Laboratories;Machine Learning;Maintenance;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Medicine;member;Methylation;Microarray Analysis;Micrococcal nuclease digestion of chromatin followed by sequencing;Monitor;Natural Language Processing;next generation sequencing;oncology trial;Outcome;Paper;Pathology;Pathway interactions;personalized medicine;Phase;Physiological;Population Sciences;preclinical study;programs;protocol development;public database;Publications;randomized, clinical trials;Reporting;Research;Research Design;Research Personnel;Resource Sharing;Secure;Services;Statistical Data Interpretation;Statistical Methods;statistics;success;Surveys;System;tool;transcriptome;Variant;variant detection;web platform;Work

PROJECT_TITLE: Quantitative Data Sciences Core Facility Shared Resource


PI_NAMEs: MONDRAGON, ALFONSO  (contact)

PROJECT_TERMS: Area;base;Basic Science;Binding;Biocompatible Materials;Biological;Cancer Center;Communities;Complex;Comprehensive Cancer Center;computer infrastructure;Consultations;Cryoelectron Microscopy;Crystallization;Crystallography;Data;data acquisition;Data Analyses;Data Collection;Drug Design;drug discovery;Electron Microscope;Electron Microscopy;Ensure;Equipment;experience;experimental study;Growth;Human Resources;Instruction;instrumentation;interest;Investigation;Laboratories;Ligands;macromolecule;Methodology;Methods;Mission;Modeling;Modernization;Molecular;Molecular Conformation;Molecular Structure;Nature;operation;particle;Pharmaceutical Preparations;Photons;Play;Preparation;Process;programs;reconstruction;Research;Research Personnel;Resolution;Resource Sharing;Resources;Roentgen Rays;Role;Sampling;Services;simulation;Source;Structural Biologist;structural biology;Structure;synchrotron radiation;Technical Expertise;Techniques;Therapeutic;tomography;tool;Training;Translating;Universities;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Structural Biology Facility Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: AWATRAMANI, RAJESHWAR B (contact)

PROJECT_TERMS: Animal Husbandry;Archives;base;Biological Assay;blastocyst;Breeding;Cancer Center;Cell Culture Techniques;Chimera organism;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;Comprehensive Cancer Center;Consultations;cost;CRISPR/Cas technology;cryobiology;Cryopreservation;Dedications;Derivation procedure;design;Development;Diagnostic;DNA purification;DNA Sequence Alteration;Doctor of Philosophy;Effectiveness;Embryo;embryonic stem cell;Emerging Technologies;Engineering;Epididymis;Equipment;ES Cell Line;Faculty;Fertilization in Vitro;flexibility;Foundations;Freezing;Future;gene editing technology;Gene Modified;Gene Targeting;Generations;Genes;Genetic;Genetic study;Genetically Engineered Mouse;genome editing;Genome engineering;Genomics;Genotype;Germ;Germ Lines;Individual;Infrastructure;insight;Laboratories;laboratory facility;Maintenance;Malignant Neoplasms;Mediating;member;Methodology;Methods;Microinjections;Microsurgery;Mission;Modification;Molecular;mouse model;Mouse Strains;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutation;novel;pathogen;Positioning Attribute;Production;programs;Reagent;Recovery;Recurrence;Research;Research Personnel;Resource Sharing;Resources;Role;screening;Services;skills;Solid;sperm cell;sperm cryopreservation;System;Technical Expertise;Techniques;Technology;Therapeutic;Time;Transgenic Mice;Transgenic Organisms;Translating;tumor progression;Universities;Validation;vector;Work

PROJECT_TITLE: Transgenic and Targeted Mutagenesis Laboratory Shared Resource


PI_NAMEs: CARTHEW, RICHARD W. (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Advocate;Affect;Architecture;Arts;Basic Science;Biological Models;Biological Sciences;Caenorhabditis elegans;cancer cell;Cancer Center;Cancer Center Support Grant;cancer type;Catchment Area;cell behavior;Cell Nucleus;Cells;Cellular biology;chemotherapy;Chromatin;Clinic;Clinical;Clinical Investigator;clinical translation;Collaborations;college;Comprehension;Comprehensive Cancer Center;Data Science Core;Development;DNA;Doctor of Philosophy;Drosophila genus;Ensure;Epigenetic Process;epigenetic regulation;Faculty;Frequencies;Funding;Future;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genome;genome-wide;Goals;Human;Human Genome;Immunologic Surveillance;insight;Leadership;Malignant - descriptor;Malignant Neoplasms;Mediator;medical schools;meetings;member;MicroRNAs;Microscopy;Modification;Molecular;mouse model;Mutation;Neoplasm Metastasis;neoplastic cell;novel anticancer drug;novel diagnostics;novel therapeutics;Nuclear;Oncogenes;Organelles;Organizational Change;Organizational Objectives;Peer Review;Pharmacology;Positioning Attribute;Process;professor;programs;Property;Proteins;Proteomics;Publications;Research;Research Personnel;Research Support;Resource Sharing;RNA;RNA Polymerase II;Schools;Science;Series;Signal Transduction;Source;Structure;symposium;Technology;Therapeutic;transcription factor;Translating;Translational Research;translational scientist;Translations;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;United States National Institutes of Health;Untranslated RNA;Work;Yeasts

PROJECT_TITLE: Cancer Epigenetics and Nuclear Dynamics (CEND) Research Program


PI_NAMEs: CHANDEL, NAVDEEP S (contact)

PROJECT_TERMS: Acceleration;Address;Articulation;Basic Science;Binding;Biochemical Reaction;Biogenesis;Biological Markers;Biological Sciences;Biology;cancer cell;Cancer Center;cell growth;Cell membrane;Cell Proliferation;cell transformation;Cells;Cellular biology;Cellular Membrane;Clinical;cohort;Collaborations;Communication;Comprehensive Cancer Center;Core Facility;Cytokine Signaling;data sharing;design;Development;Diagnosis;Division of Basic Sciences;Doctor of Philosophy;Educational workshop;Faculty;Fostering;Funding;Future;Gene Expression;Gene Expression Regulation;Laboratories;Lead;Leadership;Life;Link;Malignant - descriptor;Malignant Neoplasms;Medicine;meetings;member;Membrane;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Molecular;Molecular Biology;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel therapeutics;Organelles;Oxidative Stress;pathogen;Pathway interactions;Peer Review;professor;Prognosis;programs;Publications;recruit;Research;Research Personnel;Research Support;Resources;response;Risk Assessment;Schools;scientific organization;Series;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Source;symposium;synergism;System;therapeutic target;tool;Translations;tumor;tumor growth;tumor metabolism;tumor progression;tumorigenesis;Work

PROJECT_TITLE: Membranes, Organelles, and Metabolism (MOM) Research Program


PI_NAMEs: MUNSHI, HIDAYATULLAH G. (contact)

PROJECT_TERMS: Acceleration;Adaptive Immune System;Address;Adhesions;Advocate;Affect;angiogenesis;Area;Basic Science;Budgets;Cancer Center;cancer initiation;Cell Adhesion;Cell Communication;Cells;Clinical;Clinical Investigator;Clinical Sciences;clinical translation;Collaborations;Comprehensive Cancer Center;Cytoskeleton;data sharing;Development;Division of Basic Sciences;Doctor of Philosophy;Drug resistance;Environment;Event;Extracellular Matrix;Faculty Recruitment;Funding;Future;Heterogeneity;imaging facilities;Immune;Immune system;Immunology;Inflammation;Innate Immune System;inter-institutional;interest;Invaded;Joints;Journals;Leadership;Link;Lymphovascular;Malignant Neoplasms;Mediating;meetings;member;Microscopy;migration;multidisciplinary;Neoplasm Metastasis;neoplastic cell;Neural Crest;Participant;Peer Review;Peer Review Grants;Population Sciences;programs;Publishing;Research;Research Personnel;Resource Sharing;Role;Schools;Series;Signal Transduction;Source;symposium;System;therapy resistant;Translational Research;tumor;Tumor Cell Invasion;tumor immunology;tumor progression;Tumor Promotion;Universities;Work;working group

PROJECT_TITLE: Tumor Environment and Metastasis (TEAM) Research Program


PI_NAMEs: BACKMAN, VADIM  (contact)

PROJECT_TERMS: Acceleration;anti-cancer research;anti-cancer therapeutic;Area;Award;Basic Science;Binding;Biological;Biological Assay;Biological Markers;Biomedical Engineering;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Diagnostics;Cancer Science;cancer therapy;carcinogenesis;Chemistry;Clinic;Clinical;clinical care;clinical translation;Clinical Trials;Clone Cells;Collaborations;Communities;Comprehensive Cancer Center;Coupled;design;Detection;Development;Diagnosis;Diagnostic;Doctor of Philosophy;Drug Delivery Systems;Early Diagnosis;Educational workshop;Emerging Technologies;Engineering;Evolution;Exhibits;Faculty;Faculty Recruitment;Fostering;Funding;Future;Genomics;Image;imaging agent;imaging modality;Imaging technology;in vivo;Industry;Infrastructure;innovation;International;Investigation;Journals;Leadership;Link;Malignant Neoplasms;materials science;member;Methods;Modality;Molecular;nanoscale;Nanotechnology;new technology;novel;novel therapeutics;Oncology;Pathway interactions;Peer Review;physical science;Physics;practical application;Process;prognostication;programs;Publications;recruit;Research;Research Personnel;Resolution;Schools;Science;Scientist;Screening for cancer;Social Network;symposium;synergism;systemic toxicity;targeted agent;targeted treatment;Technology;technology development;Therapeutic;Therapeutic Agents;tool;translational pipeline;Translational Research;Translations;tumor;tumor heterogeneity;tumorigenesis;Universities;Visualization;webinar;Work

PROJECT_TITLE: Cancer and Physical Sciences (CAPS) Research Program


PI_NAMEs: PETER, MARCUS E. (contact)

PROJECT_TERMS: Acceleration;Adult;Animal Cancer Model;anti-cancer research;Antineoplastic Agents;Applications Grants;Area;Automobile Driving;Award;Basic Science;bench to bedside;Brain;Brain Neoplasms;Breast;cancer biomarkers;cancer cell;Cancer Center;cancer immunotherapy;cancer initiation;cancer stem cell;career;Catchment Area;Cell Survival;Cellular biology;cellular targeting;Center for Translational Science Activities;Chemoresistance;Childhood;Clinic;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;clinically relevant;Collaborations;Comprehensive Cancer Center;Dermatologic;Development;diagnostic strategy;Disease;Doctor of Philosophy;Drug Delivery Systems;Faculty;Fostering;Funding;gastrointestinal;Genitourinary system;Goals;Grant;Immune;improved outcome;insight;inter-institutional;Intervention;Intervention Studies;Intervention Trial;Investigation;investigator-initiated trial;Leadership;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;member;Mentors;MicroRNAs;Mission;Molecular;Molecular Biology;nanoparticle;Nanotechnology;new therapeutic target;novel;novel diagnostics;novel strategies;novel therapeutic intervention;novel therapeutics;Oligonucleotides;Oncogenic;Pathway interactions;Patient-Focused Outcomes;Patients;Peer Review;Peer Review Grants;Population;Pre-Clinical Model;predictive marker;Productivity;prognostic;Prognostic Marker;programs;Prostate;Publications;Publishing;recruit;Research;Research Infrastructure;Research Personnel;research study;resistance mechanism;Role;Sarcoma;Schools;Science;Scientific Advances and Accomplishments;Site;skills;Small Interfering RNA;Solid Neoplasm;Source;symposium;Testing;Therapeutic;Therapeutic Clinical Trial;Therapeutic Uses;Translating;Translational Research;Translations;treatment strategy;tumor;tumor microenvironment;tumor progression;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: Translational Research in Solid Tumors (TRIST) Research Program


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: EKLUND, ELIZABETH ANN (contact)

PROJECT_TERMS: Acute leukemia;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;adverse outcome;Area;Cancer Center;Caring;Cells;Chronic Leukemia;Chronic Lymphocytic Leukemia;Chronic Myeloid Leukemia;Clinical;Clinical Investigator;Clinical Trials;Collaborations;Combination Drug Therapy;Comprehensive Cancer Center;Cytotoxic agent;Data;Disease;efficacy evaluation;Elderly;Epigenetic Process;evidence base;Faculty;Fostering;Funding;Gene Expression;Goals;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;High Density Lipoproteins;Hodgkin Disease;improved;Institution;inter-institutional;interest;Intervention;Investigation;investigator-initiated trial;kinase inhibitor;Laboratories;Laboratory Scientists;Laboratory Study;large cell Diffuse non-Hodgkin's lymphoma;leukemia;Lymphoid;Lymphoma;Lymphopoiesis;Malignant - descriptor;Malignant lymphoid neoplasm;Malignant Neoplasms;Megakaryocytes;member;Modification;Molecular;Molecular Target;molecular targeted therapies;multidisciplinary;Multiple Myeloma;Myelogenous;Myeloid Leukemia;Myelopoiesis;Myeloproliferative disease;nanoparticle;Non-Hodgkin's Lymphoma;novel;Outcome;Paper;Pathway interactions;Patients;Peer Review;Pharmaceutical Preparations;Prognosis;programs;Publications;Publishing;Research;Research Personnel;Schools;Scientist;Signal Transduction;Source;Subgroup;Supportive care;Survival Rate;symposium;Talents;Therapeutic Clinical Trial;therapeutic target;therapeutically effective;Translational Research;translational scientist;translational study;Translations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Hematologic Malignancies (HM) Research Program


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health;Women's Health Research

PI_NAMEs: KHAN, SEEMA AHSAN (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Adherence;Area;Atypia;Automobile Driving;Basic Science;Behavior;Behavior Therapy;Behavioral;behavioral study;Biological Markers;Breast Cancer Detection;Breast Cancer Prevention;Cancer Burden;Cancer Center;cancer prevention;Cancer Prevention Intervention;cancer risk;carcinogenicity;Catchment Area;Cellular Phone;Cervical Cancer Screening;Chicago;Clinical;Collaborations;Colon Carcinoma;Colonic Neoplasms;Communities;community intervention;community setting;Comprehensive Cancer Center;design;Development;Devices;Direct Costs;Discipline;Disease;DNA Methylation;Doctor of Philosophy;Early Diagnosis;Enrollment;Environment;Environmental Risk Factor;epigenetic marker;Epithelium;Faculty;Fostering;Funding;Genetic Markers;Genetic Predisposition to Disease;Goals;Health;improved;Incidence;Individual;individualized prevention;Indolent;innovation;inter-institutional;interest;Interruption;Intervention;Intervention Trial;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;member;Methods;metropolitan;MicroRNAs;mortality;multidisciplinary;new technology;novel;novel marker;novel strategies;Oncogenic Viruses;Participant;Pathway interactions;Peer Review;Pharmaceutical Preparations;pharmacologic;Phase;Population;Predisposition;prevent;Prevention;Prevention approach;Prevention program;Prevention Research;Preventive;Primary Cancer Prevention;programs;Psychologist;psychosocial;Publications;Research;Research Personnel;Risk;Risk Assessment;Risk Factors;Risk Reduction;Risk Reduction Behavior;risk stratification;Safety;Schools;screening;Screening for cancer;Secondary Cancer Prevention;skin lesion;smoking cessation;Smoking Cessation Intervention;social media;Source;specific biomarkers;success;sun protection;Surgeon;Technology;Testing;Therapeutic;tool;Translating;Translational Research;translational scientist;transmission process;Underserved Population;United States National Institutes of Health;Vertebral column;Virus Diseases;wearable sensor technology;Weight maintenance regimen;Work

PROJECT_TITLE: Cancer Prevention (CP) Research Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PI_NAMEs: RINI, CHRISTINE  (contact)

PROJECT_TERMS: Acute;Address;Adherence;anti-cancer research;Basic Science;Behavioral;Biological;Calendar;Cancer Burden;cancer care;Cancer Control;cancer diagnosis;Cancer Patient;cancer prevention;Cancer Survivor;Cancer Survivorship;care delivery;Caring;Catchment Area;chemotherapy;Childhood;Chronic;Clinic;Clinical;clinical application;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Communities;community setting;Comprehensive Cancer Center;Correlative Study;Data;design;Development;Disparity in diagnosis;dissemination science;effective intervention;eHealth;Enrollment;Evaluation;Evidence based intervention;experience;Faculty;fertility preservation;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Grant;Health;health related quality of life;implementation science;improved;innovation;inter-institutional;Intervention;intervention delivery;Intervention Studies;Lead;Leadership;lifestyle factors;Long-Term Effects;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;Medical Oncology;meetings;member;Methods;multidisciplinary;neural;Observational Study;Outcome;Outcome Measure;Participant;Patient Care;Patient Outcomes Assessments;Patient-Centered Care;Patients;Peer Review;person centered;Policies;precision oncology;Preservation Technique;Process;programs;Psychometrics;psychosocial;Publications;Quality of Care;reduce symptoms;Research;Research Personnel;Resource Sharing;Schools;Science;Scientist;Series;Service delivery model;Services;social culture;sociocultural determinant;Source;Strategic Planning;stress management;Supportive care;Surgical Oncology;survivorship;Symptom Burden;Techniques;Technology;therapy development;Time;tool;Toxic effect;Translational Research;Translations;treatment optimization;Underserved Population;Validation;Vision;Work

PROJECT_TITLE: Cancer Control and Survivorship (CCS) Research Program


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention

PI_NAMEs: SIMON, MELISSA A. (contact)

PROJECT_TERMS: Accounting;Address;Advocacy;advocacy organizations;Advocate;Area;Assessment tool;Basic Science;Cancer Burden;cancer care;Cancer Center;cancer education;Cancer Etiology;cancer health disparity;cancer prevention;Catchment Area;Charge;Chicago;Clinical Research;Clinical Trials;Communities;community engagement;Community Health;community organizations;Community Outreach;community partners;Comprehensive Cancer Center;County;Data;Data Sources;Databases;Disparity;Education;Education and Outreach;Equity;evidence base;Exhibits;Funding;Goals;Health;health care availability;health care service;health inequalities;health organization;Health Status;Illinois;Improve Access;improved;Incidence;Lead;Leadership;Malignant Neoplasms;Medicine;member;metropolitan;minority health;Mission;Modification;Monitor;mortality;multiple data sources;NCI Center for Cancer Research;Needs Assessment;neoplasm registry;obesity prevention;Outcomes Research;outreach;patient population;Persons;Policies;Policy Developments;Policy Maker;Population;population based;Population Research;Public Health;Quality of Care;Research;Role;Science;screening;Screening for cancer;Surveys;survivorship;System;Target Populations;Tobacco Use Cessation;translational cancer research;Translational Research;treatment and outcome;underserved community;Voice;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Immunotherapy

PI_NAMEs: PLATANIAS, LEONIDAS C. (contact)

PROJECT_TERMS: Area;Award;base;Basic Science;Cancer Center;Cancer Center Support Grant;cancer epidemiology;Categories;Clinical Sciences;Clinical Trials;Comprehensive Cancer Center;Core Facility;Development;drug discovery;Ensure;epidemiologic discoveries;Epigenetic Process;Equipment;Extramural Activities;Faculty;Faculty Recruitment;faculty support;Funding;Goals;Grant;Growth;Guidelines;Immunotherapy;innovation;Institution;interdisciplinary collaboration;Investments;Leadership;Malignant Neoplasms;member;metabolomics;Pilot Projects;Population Sciences;Process;programs;Proteomics;Publications;recruit;Research;Research Personnel;Resource Sharing;Resources;Scientist;Services;Source;Strategic Planning;Surveys;Technology;Translational Research;tumor immunology;United States National Institutes of Health

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Advisory Committees;Appointment;Award;Basic Science;Biometry;Cancer Center;Cancer Center Support Grant;Cancer Control Research;cancer prevention;cancer research center director;Catchment Area;Clinical;Clinical Cancer Center;Clinical Research;Clinical Sciences;Communities;Community Healthcare;Comprehensive Cancer Center;Decision Making;Development;Doctor of Medicine;Doctor of Philosophy;Ensure;Environment;Equity;Evaluation;Evaluation Research;Event;Extramural Activities;Family;Feedback;Funding;Goals;Growth and Development function;Health Professional;improved;Institution;Joints;Leadership;Master of Business Administration;meetings;member;minority health;Mission;multidisciplinary;operation;Operations Research;outreach;Pathway interactions;Patients;Physicians;Play;Policies;Population Research;Population Sciences;Positioning Attribute;Process;programs;Research;Research Activity;Research Personnel;Resource Sharing;Resources;Role;Strategic Planning;Structure;success;Surveys;symposium;System;Training;Training and Education;Translational Research;Vision;Work;working group

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: MAHALINGAM, DEVALINGAM  (contact)

PROJECT_TERMS: Address;African American population;Area;Cancer Center;Catchment Area;Child;Childhood;Clinical Cancer Center;Clinical Data;Clinical Management;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Trials;clinically relevant;Communities;Comprehensive Cancer Center;Conduct Clinical Trials;Consent Forms;County;Data;data management;design;Development;Disease;Disparity;Education;Ensure;Ethnic Origin;Grant;improved;Incidence;Institutional Policy;Intervention;Intervention Trial;Logistics;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;member;Minority;Minority Groups;Monitor;Office Management;online repository;participant enrollment;patient population;patient safety;Patients;Population;Procedures;Process;programs;protocol development;Protocols documentation;Regulation;Reporting;Research;Research Personnel;Resources;Review Committee;Safety;Scientific Evaluation;Series;Services;Site;Site Visit;sound;Standardization;System;tool;Training;Training and Education;Underserved Population;web-based tool;Woman;Work

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PI_NAMEs: BENSON, AL B (contact)

PROJECT_TERMS: authority;Behavioral Sciences;Biometry;Cancer Center;Clinical Oncology;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Committee Membership;Communication;Comprehensive Cancer Center;Data Science;Discipline;Disease;Doctor of Philosophy;Ensure;falls;Goals;Grant;Health Sciences;improved;Malignant Neoplasms;member;Monitor;multidisciplinary;NCI Center for Cancer Research;Patients;Pharmacy facility;programs;Protocols documentation;Research;Review Committee;Role;System;Translational Research

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: AI

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Vaccine Related

ORG_CITY: WASHINGTON D.C.

ORG_NAME: IAS

ORG_STATE: DC

PHR: Project Narrative AIDS 2024, the 25th International AIDS Conference, will be held from 22-26 July 2024 in Munich (Germany) and virtually. With an expected attendance of 15,000 participants, it will be an essential convening to bring together all stakeholders to review the evidence, debate course corrections, renew the global consensus that the AIDS crisis is not over and unite the global HIV response behind an evidence-based approach that puts people first, the theme chosen for AIDS 2024. Germany offers a compelling location as a center of scientific excellence and a leader of the HIV response in Europe. The special focus of the conference on the fast-growing HIV epidemic in Central and Eastern Europe will translate into implementation science and policy discussions on the challenges of sustaining HIV efforts in contexts of political neglect, armed conflict and displacement, and a strong involvement of scientists, policy makers and implementers from the region.

PI_NAMEs: BEYRER, CHRISTOPHER C. (contact);LEWIN, SHARON RUTH

PROGRAM_OFFICER_NAME: GUTIERREZ, MARTIN

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Advocate;Aging;AIDS prevention;Americas;Anti-Retroviral Agents;antiretroviral therapy;Area;Attention;Basic Science;Behavioral Research;Caring;Cessation of life;Cities;Clinical Research;co-infection;Communities;comorbidity;Complex;Conflict (Psychology);Consensus;cost;Country;COVID-19;design;Development;Discipline;Discrimination;Disease Progression;Eastern Europe;economic determinant;Economics;efficacy trial;Ensure;Epidemic;epidemiology study;ethnic disparity;Europe;evidence base;Funding;Gays;Gender;Germany;global health;Goals;health determinants;Health Services Accessibility;Health system;HIV;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;HIV/AIDS;Homophobia;Human;Human Rights;Hybrids;implementation barriers;implementation research;implementation science;Incidence;Individual;Infection;Infrastructure;Injectable;Injecting drug user;innovation;International;International AIDS;Intervention;Investments;Laboratories;Laws;Leadership;Legal;Location;member;men;men who have sex with men;migration;Modality;Modeling;multidisciplinary;neglect;next generation;novel;Oral;pandemic disease;Participant;Pathogenesis;person centered;Personal Satisfaction;Persons;Policies;Policy Maker;Politics;Population;pre-exposure prophylaxis;prevent;Prevention;Prevention Research;programs;Public Health;racial disparity;Reporting;Research;Research Personnel;Resources;response;Scholarship;Science;Scientific Advances and Accomplishments;Scientist;Series;service delivery;service uptake;sex;Site;social;social stigma;Southern Africa;structural determinants;symposium;synergism;System;Technology;Thinking;Training;transgender;Translating;Translational Research;transmission process;transphobia;Tuberculosis;Ukraine;uptake;Vaccines;virtual;Vulnerable Populations;War;Woman;Work;Youth

PROJECT_TITLE: AIDS 2024, the 25th International AIDS Conference, Munich, Germany, and virtually 22-26 July 2024

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative  Transcription factors control gene expression by binding near target genes to regulate their expression. How transcription factors find their target sites remains poorly understood, yet dysregulation of gene expression is a major cause of disease. Here we propose to resolve this using a new microscope modality that allows tracking of single transcription factors at extremely high spatiotemporal resolution.

PI_NAMEs: HANSEN, ANDERS SEJR (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Award;Behavior;Binding;Binding Sites;Cancer Biology;Cancer Etiology;cancer initiation;Cell Nucleus;Cell Physiology;Cells;Chromatin;computational suite;Computing Methodologies;Crowding;Data;design;Development;Diffusion;Discrimination;Disease;DNA;DNA Binding;DNA Binding Domain;empowerment;Enhancers;Exhibits;fascinate;Gene Activation;Gene Expression;Gene Expression Regulation;gene therapy;Genes;Genetic Transcription;Genome;Human;Image;imaging modality;improved;In Vitro;Individual;innovation;insight;Investigation;Length;Malignant Neoplasms;Mammalian Cell;Methods;Microscope;Microscopy;Modality;Mus;Nature;novel;novel strategies;Nuclear Proteins;off-target site;Oncogenic;Oncoproteins;Peptide Initiation Factors;Photobleaching;pluripotency;preservation;Process;promoter;Property;rational design;recruit;Research;Research Personnel;Resolution;single molecule;Site;Slide;spatiotemporal;Structure;synthetic biology;Techniques;Technology;temporal measurement;Tertiary Protein Structure;Textbooks;Time;transcription factor;Validation

PROJECT_TITLE: Resolving transcription factor target search mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Q (70)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative  Understanding how cancer cells reprogram their metabolism and interact with other biological processes to gain aggressiveness and/or resistance to a treatment is of paramount significance to advancing current diagnosis and treatment strategies. Bio-orthogonal mid-infrared photothermal imaging will be developed to quantitatively measure various metabolites at subcellular level. This technology will open exciting opportunities for molecule- based precision diagnosis and discovery of novel targets for precision treatment of cancers and other diseases.

PI_NAMEs: CHENG, JI-XIN  (contact)

PROJECT_TERMS: absorption;Alkynes;Amino Acids;Biological Process;cancer cell;cancer imaging;cancer stem cell;Caspase;Cell Communication;cell type;Cells;cellular imaging;Cellular Metabolic Process;chemical bond;Chemicals;Cholesterol;Cholesterol Esters;Choline;Clinical;Collaborations;commercialization;Complex;Couples;Cues;Detection;detection limit;detection of nutrient;detection sensitivity;Development;Diagnosis;Disadvantaged;Disease;Electronics;Environment;enzyme activity;Enzymes;Event;fatty acid oxidation;Fatty Acids;Feasibility Studies;Fluorescence Microscopy;fluorophore;Glucose;Glycolysis;Heating;high resolution imaging;Image;Imaging Device;imaging modality;Imaging technology;improved;innovation;insight;instrumentation;interest;Label;Lasers;Libraries;Magnetic Resonance Imaging;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Measurement;Measures;Medical Imaging;Metabolic;Metabolism;metabolomics;Microscope;Microscopy;millisecond;Molecular;molecular imaging;Molecular Profiling;Nature;Nitriles;novel;novel strategies;Nutrient;nutrient metabolism;Phosphoric Monoester Hydrolases;Platinum;Positron-Emission Tomography;Precision cancer therapy;Process;programs;quantum;Refractive Indices;Research Personnel;Resistance;Resolution;response;Saturated Fatty Acids;Scanning;sensor;Series;Side;Signal Transduction;small molecule;spectral distortion;spectroscopic imaging;Spectrum Analysis;Speed;submicron;targeted imaging;Technology;Tissues;treatment strategy;tumor heterogeneity;tumor metabolism;Universities;Unsaturated Fatty Acids;uptake

PROJECT_TITLE: Bio-orthogonal Mid-Infrared Photothermal Imaging of Cancer Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-D (M2)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: AMHERST

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Understanding how dopamine neuronal circuits are affected by methamphetamine-induced mitochondrial oxidative damage will help to identify the cellular mechanism that leads to methamphetamine addiction. Here, we will use a cell to system integrative approach with transcriptomics, bioinformatics and viral neuronal tracing technologies to identify anatomical, metabolic, and molecular characteristics of dopamine microcircuits vulnerable or resistant to chronic methamphetamine self-administration. In the long-term, our research will contribute knowledge to develop novel therapeutics to offer a healthier life quality for those fighting addiction.

PI_NAMEs: DOMINGUEZ LOPEZ, SERGIO  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Affect;Anatomy;Antioxidants;Applications Grants;Axon;Behavior;Behavioral;Bioinformatics;Brain;brain research;career;career development;Cells;Censuses;Characteristics;Chicago;Chronic;Classification;Collaborations;Data;Development Plans;Dopamine;dopaminergic neuron;Drug Addiction;Drug Controls;Drug Modelings;drug seeking behavior;Educational Models;Electrophysiology (science);Environment;Event;experience;fighting;Fluorescence-Activated Cell Sorting;Foundations;Functional disorder;Gene Expression Profile;Genetic;genetic profiling;Genetic Recombination;Genetic Transcription;Glutathione;Glutathione Disulfide;Grant;High Pressure Liquid Chromatography;Holly;Homeostasis;immunocytochemistry;Injections;innovation;Intake;Knowledge;Label;Laboratories;Location;Measures;Mediating;Medical Research;member;Mentors;Mentorship;Metabolic;Methamphetamine;Methamphetamine dependence;methamphetamine effect;methamphetamine exposure;Methodology;Mitochondria;mitochondrial metabolism;Molecular;mouse model;Mus;Nerve Degeneration;Neurobiology;neuronal circuitry;Neurons;neurotransmission;novel;novel therapeutics;Oklahoma;Oxidation-Reduction;oxidative damage;Oxidative Stress Induction;Oxygen Consumption;patch clamp;Pathway interactions;Population;Predisposition;Preparation;Presynaptic Terminals;programs;Property;Quality of life;Reporter;Research;Research Activity;Research Personnel;Research Proposals;Resistance;Resolution;Respiration;Role;Scientist;Secure;Self Administration;single-cell RNA sequencing;Site;skills;Spirometry;Stains;Survival Rate;Synaptic Transmission;System;Tamoxifen;Technology;Testing;Theoretical model;Therapeutic;Time;tool;Training;Training Activity;transcriptomics;Underrepresented Populations;Universities;Ventral Tegmental Area;Viral;Virus;Visualization;Work;Writing

PROJECT_TITLE: Dopamine Neuronal Microcircuits Controlling Methamphetamine Seeking Behavior


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: Boston

ORG_NAME: SYNTIS BIO INC

PHR: NARRATIVE Peptide macromolecules are an attractive therapeutic class for treating a variety of conditions, but their poor absorption in the GI tract has made oral delivery a significant challenge. Syntis Bio is developing an oral therapeutics platform, GSEL, that increases the GI residence time of peptide drugs to improve their systemic absorption. This project aims to identify GSEL-compatible formulations of model peptide drugs and create tablets for oral delivery.

PI_NAMEs: SETHURAMAN, VASU  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: absorption;Adherence;Aging;Antiparasitic Agents;Biological Assay;Biological Availability;Canis familiaris;capsule;Cellular Assay;Chronic;Chronic Disease;Clinical;Communicable Diseases;comparison control;design;Disease;dosage;Dose;Drug Compounding;Drug Targeting;Duodenum;Engineering;Enhancers;Enteral;Enteric-Coated Tablets;Environment;Epithelium;Excipients;Family suidae;first-in-human;Formulation;Gastric Emptying;gastrointestinal;Gastrointestinal tract structure;Half-Life;High Pressure Liquid Chromatography;Hour;improved;in vivo;Incubated;Inflammatory;Injections;Intestinal permeability;Intestines;Kinetics;Lead;Liquid substance;macromolecule;manufacturability;manufacture;Metabolic Diseases;Methods;Minor;Modality;Modeling;Modification;Molecular;Oral;Oral Administration;Patients;peptide drug;Peptides;Pharmaceutical Preparations;Phase;Polymers;porcine model;Praziquantel;Proteins;Psyche structure;Recovery;residence;Small Business Innovation Research Grant;Small Intestines;small molecule;Solid;Source;Stomach;Tablets;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;Toxic effect;Work

PROJECT_TITLE: Polymer Epithelial Lining for the Oral Delivery of Macromolecules

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (10)]


ADMINISTERING_IC: GH

IC_NAME: Center for Global Health

ORG_CITY: Bangkok

ORG_COUNTRY: THAILAND

ORG_FIPS: TH

ORG_NAME: CHULALONGKORN UNIVERSITY

PHR: PROJECT NARRATIVE This proposed public health and academic research network (iPHAC-IDC) brings in-country partners in infectious diseases prevention and control in Thailand from the Department of Diseases Control, the Department of Medical Sciences, the Thai Red Cross Society, Chulalongkorn University, and world-class international partners to build a pandemic preparedness system by developing faster and wiser outbreak response using molecular, serologic, and data integration tools. In addition, this team will develop and implement a post- graduate GLLP curriculum at Chulalongkorn University for sustainable and long-term public health workforce development. The network will conduct HIV and STI prevention and detection research to reduce new HIV cases in Thailand by developing adolescent HIV prevention with pre-exposure prophylaxis using social network strategies and enhancing the gonorrhea antimicrobial resistance surveillance system.

PI_NAMEs: WACHARAPLUESADEE, SUPAPORN  (contact)

PROJECT_TITLE: Integrated Public Health and Academic Collaboration for Infectious Diseases Control (iPHAC-IDC): Implementation of One Health approaches to pandemic preparedness and adolescent HIV prevention


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Stroke injury and recovery are often made worse by comorbid metabolic conditions including obesity and diabetes yet there are few evidence-based stroke-treatments that address these interactions. Testing of experimental stroke here has identified a novel synaptic mechanism of the corticospinal motor pathway that may underpin comorbid metabolic conditions impeding stroke recovery. This proposal aims to fully understand this synaptic mechanism in order to guide its future targeted treatment as a novel therapy for stroke recovery in the context of clinically- relevant comorbid metabolic conditions.

PI_NAMEs: BOYCHUK, JEFFERY ALLEN (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Action Potentials;Address;Adhesives;Affect;Animals;Anterior;Area;Axon;Behavioral;Biology;Cells;Cerebrovascular Circulation;Cervical;Cervical spinal cord structure;clinically relevant;Color;comorbidity;Complex;Consumption;Corticospinal Tracts;Dedications;Diabetes Mellitus;Diet;dietary control;disability;DNA cassette;Electrical Stimulation of the Brain;Electromyography;Energy consumption;evidence base;Evidence based treatment;Excision;Exhibits;experimental study;Fatty acid glycerol esters;Fluorescence;Food;foot;Forelimb;Future;Goals;High Fat Diet;Hindlimb;Human;Impairment;in vivo;Individual;Injury;Ischemic Stroke;Knowledge;Label;Light;Limb structure;Lower Extremity;Lumbar spinal cord structure;Measures;Metabolic;middle cerebral artery;Middle Cerebral Artery Occlusion;Modeling;mortality;Motor;motor behavior;motor control;Motor Cortex;motor deficit;motor impairment;Motor Neurons;Motor Pathways;motor recovery;Motor Skills;Movement;Mus;nerve supply;neural circuit;Neurons;neurotransmission;novel;novel therapeutics;Obesity;Optics;Output;patch clamp;Pathway interactions;Pattern;Physiology;post stroke;Property;Pyramidal Cells;Recovery;Resistance;Risk Factors;Role;Signal Transduction;Site;Skeletal Muscle;skills;Slice;Source;Spinal;Spinal Cord;Stroke;stroke recovery;stroke therapy;Synapses;System;targeted treatment;Techniques;Testing;Tissues;Transgenic Organisms;Upper Extremity;Variant;Vertebral column;Viral;Virus;Visualization

PROJECT_TITLE: CORTICOSPINAL MECHANISMS FOR HIGH FAT DIET IMPEDING STROKE RECOVERY

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Sleep Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative HIV co-infection accelerates liver cirrhosis and liver cancer in chronic hepatitis B virus (HBV) carriers. In addition, HIV is associated with more severe fatty liver disease. The use of unique primary cell culture models and humanized mice under conditions that maintain or disrupt the circadian rhythm of hepatocytes will determine the interaction of HIV co-infections and co-morbidities with the circadian rhythm. These studies will provide information for HIV pathogenesis in the liver and may help the development of novel antiviral strategies.

PI_NAMEs: MICHAILIDIS, ELEFTHERIOS  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, KHOA DINH DANG

PROJECT_TERMS: Acceleration;Anti-viral Agents;Area;Biological Process;Cell Culture Techniques;Chronic Hepatitis B;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;co-infection;comorbidity;Complex;Development;Disease;drug metabolism;Fatty Liver;fatty liver disease;Genes;Health;Hepatitis B Virus;Hepatocyte;HIV;humanized mouse;in vivo;innovation;Intestinal permeability;Lead;Liver;Liver Cirrhosis;Malignant neoplasm of liver;Metabolic;Metabolism;Modeling;non-alcoholic fatty liver disease;novel;Pathogenesis;Pathway interactions;Persons;Physiological;Predisposition;Primary Cell Cultures;Research;System;Technology;Viral;Viral hepatitis

PROJECT_TITLE: Impact of HIV co-infections and comorbidities on circadian rhythm in the liver

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-P (55)]


NIH_SPENDING_CATS: Arthritis;Clinical Research;Infectious Diseases;Lyme Disease;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: Boxborough

ORG_NAME: HELIXBIND, INC.

PHR: PROJECT NARRATIVE Rapid and effective diagnosis of Lyme Disease (LD) is an urgent and unmet clinical need. If diagnosed early and treated with appropriate antibiotics, outcomes for LD are typically excellent, but delays in treatment result in arthritis, carditis, or neuroborreliosis. The current standard of care for in-vitro diagnosis, relying on serological tests, lacks both specificity and sensitivity, and cannot distinguish among an active and previous infection. Molecular diagnostic methods for direct detection, while widely appreciated to be the path forward, have persistently demonstrated poor sensitivity. HelixBind has developed RaPID/LD, a best-in-class diagnostic test for the detection of early LD directly from blood with markedly improved performance attributes compared to any other commercially available test. In this CRP, HelixBind will complete the tasks necessary to launch RaPID/LD. The information provided would provide the clinician with objective information on how to identify patients with an active infection weeks before serological test results are useful.

PI_NAMEs: SINGER, ALON  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: acute infection;Address;Allergic Reaction;Antibiotics;Area;Arthralgia;Arthritis;assay development;Bacteria;Biological Assay;Blinded;Blood;Blood Circulation;Borrelia;Borrelia Infections;Budgets;Carditis;Cells;Chronic;CLIA certified;Clinical;Clinical assessments;Clinical Sensitivity;commercial launch;commercialization;commercialization readiness;Data;design;Detection;detection limit;Diagnosis;Diagnostic;diagnostic assay;diagnostic platform;Diagnostic tests;Digit structure;Disease;Early Diagnosis;effectiveness testing;Ensure;Environment;erythema migrans;Exanthema;experience;Fever;General Population;Growth;Headache;Health;Health care facility;Immunoglobulin G;Immunoglobulin M;improved;In Vitro;in-vitro diagnostics;Infection;Laboratories;Lyme Disease;Lyme disease diagnosis;Marketing;member;Methods;Microbiology;Molecular;Molecular Diagnostic Techniques;Molecular Diagnostic Testing;molecular diagnostics;Myalgia;Order Spirochaetales;Outcome;pathogen;Pathway interactions;Patients;Performance;Phase;Primary Care;Prize;programs;Recovery;Relapsing Fever;Resistance;Resistance development;response;Route;Sampling;Seasons;Sensitivity and Specificity;Serology;Serology test;seropositive;Specimen;standard of care;success;Symptoms;Technical Expertise;Test Result;Testing;tick bite;tick-borne;timeline;Translating;Vector-transmitted infectious disease;verification and validation;Whole Blood

PROJECT_TITLE: Commercialization Readiness Pilot (CRP) program support for: Ultra-sensitive, direct-from-blood, molecular detection of Borrelia infections.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (19)]


NIH_SPENDING_CATS: Biotechnology;Diabetes;Obesity;Regenerative Medicine;Wound Healing and Care

ORG_CITY: ROCHESTER

ORG_NAME: EDI THERAPEUTICS LLC

PHR: NARRATIVE  Chronic wounds impose a significant and growing health care burden worldwide, and current therapeutic approaches show limited effectiveness. Topical application of the recombinant fibronectin protein, GST/FNIII1H,8,10 to full-thickness excisional wounds in genetically-diabetic mice enhances granulation tissue deposition, stimulates epithelial maturation, and promotes revascularization. The goal of this project is to advance a smaller, tagless version of this protein (FNIII1H,8,10) towards clinical application by characterizing its ability to promote healing of full thickness dermal wounds in both small (diabetic mice) and large (diabetic pigs) animal models.

PI_NAMEs: GRAHAM, MARTIN  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acceleration;Age;Aging;Anatomy;Animal Model;bacterial lysate;Binding;Biological;Biological Testing;Blood Vessels;Cell Adhesion;cell motility;cell type;Cells;Cellularity;Cessation of life;Chemistry;Chronic;chronic wound;Clinical;clinical application;clinical translation;Clinical Trials;Collagen;commercialization;Complex;compression therapy;cost effective treatment;Data;Debridement;density;Deposition;design;Development;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;diabetic ulcer;Economic Burden;effective therapy;Effectiveness;efficacy testing;Engineered skin;Epidemic;Epithelium;Event;Excision;Extracellular Matrix;Extracellular Matrix Proteins;Family suidae;Female;Fibronectins;functional mimics;Future;Glucose;Glutathione;Glutathione S-Transferase;Goals;Granulation Tissue;healing;Health;Health Care Costs;health care economics;healthcare burden;Heart Diseases;Human;Impairment;improved;in vitro activity;in vivo;Incidence;Infection;Inflammation;innovation;Insulin;Integrin alphaVbeta3;Intervention Studies;Legal patent;Length;leptin receptor;limb amputation;male;Malignant Neoplasms;manufacture;Mediating;Medical;meter;migration;mimetics;molecular mass;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obesity;Operative Surgical Procedures;Patients;peptidomimetics;Phase;Plasma;Play;Population;pre-clinical;Pre-Clinical Model;pressure;Proliferating;Property;Proteins;Quality of life;Recombinant Growth Factor;Recombinants;Recovery;response;revascularization;Sepharose;Series;Skin;Skin graft;Skin Physiology;Skin Substitutes;skin wound;Skin wound healing;Small Business Innovation Research Grant;standard of care;Sterile coverings;Stimulation of Cell Proliferation;Testing;Therapeutic;Thick;Time;tissue regeneration;tissue repair;Tissues;Topical application;Vasodilation;wound;wound healing;Wound healing therapy;Wound models;wound treatment

PROJECT_TITLE: Fibronectin matrix mimetic, Chimectin as a first-in-class therapeutic for chronic wound healing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-D (10)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Precision Medicine;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Dilated cardiomyopathy (DCM) is a leading cause of heart failure and death, and there is an urgent need to identify new molecular targets that could lead to the development of more effective treatment strategies. Our research is focused on a protein called ATF4, which acts as a switch that turns on genes essential for cardiac muscle function. By studying how ATF4 works, we hope to understand how mutations case DCM and identify new ways to treat patients.

PI_NAMEs: KARAKIKES, IOANNIS  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: biological adaptation to stress;Carbon;Cardiac;Cardiac Myocytes;cardioprotection;Cellular Stress;Cessation of life;clinically relevant;Development;Dilated Cardiomyopathy;Disease;effective therapy;familial dilated cardiomyopathy;Gene Expression;gene therapy;Genes;Genetic;Genetic Predisposition to Disease;Heart;Heart Diseases;Heart failure;in vivo;induced pluripotent stem cell;interdisciplinary approach;Mediating;Metabolism;Molecular Target;Muscle function;Mutation;Myocardium;novel;Ontology;overexpression;Pathogenesis;Pathway interactions;Patients;PF4 Gene;Physiology;precision medicine;Proteins;Regulation;Research;response;Role;Signal Transduction;Stress;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;transcription factor;Translating;treatment strategy;Work

PROJECT_TITLE: Unraveling the pathogenesis of familial dilated cardiomyopathy towards precision medicine

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Immunotherapy

ORG_CITY: ANN ARBOR

ORG_NAME: INNOVATIVE BIOTHERAPIES, INC.

ORG_STATE: MI

PHR: Narrative The goal of this proposal is to develop an effective therapy for treatment of Chronic Heart Failure (CHF), especially focused on CHF patients that have progressed to acute decompensated heart failure. The therapeutic benefit afforded by the Selective Cytopheretic Device (SCD) for treatment of CHF is based on its ability to improve cardiac function by reducing the chronic inflamed state of CHF which diminishes the pumping action of the heart The relevance of the work in this proposal to the general public is to evaluate this form of therapy in CHF patients who are so severely ill that they are not eligible for heart transplantation or the artificial heart, hoping that this treatment will improve heart function in these patients in order to bridge them to life sustaining treatment with the artificial heart.

PI_NAMEs: JOHNSTON, KIMBERLY ANNE (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Accounting;Acute;Address;Adverse event;Anticoagulation;Artificial Heart;Blood coagulation;Calcium;canine model;Canis familiaris;Cardiac;Cardiovascular Diseases;Cardiovascular system;Cells;Cessation of life;Chronic;Citrates;Clinical;Clinical Research;Clinical Trials;clinically relevant;commercialization;Congestive Heart Failure;cytokine;Devices;Disease;effective therapy;efficacy outcomes;EFRAC;Enrollment;Environment;Evaluation;Exposure to;first-in-human;Functional disorder;General Population;Goals;Heart;Heart failure;heart function;Heart Transplantation;Immune system;immunomodulatory therapies;immunoregulation;implantation;improved;Inflammation;Inflammatory;innovation;ionization;Kidney;Kidney Failure;Left;left ventricular assist device;Left Ventricular Ejection Fraction;Leukocytes;Life;Life Expectancy;Marketing;Mediator;Medical;Membrane;Modeling;mortality;Multicenter Trials;Myocardial;Myocardial dysfunction;Neurosecretory Systems;novel strategies;novel therapeutic intervention;Organ;Outcome;participant enrollment;Pathway interactions;patient population;Patients;Performance;pharmacologic;Phase;Population;pre-clinical;preclinical study;Probability;Procedures;Process;prospective;Proteins;Pump;recruit;Renal function;right ventricular failure;Safety;small molecule;System;Systemic disease;targeted treatment;technology platform;Testing;Therapeutic;Therapeutic Agents;Translating;Transplantation;treatment arm;Ventricular;Work

PROJECT_TITLE: Cell Directed Immunomodulation Therapy as a Bridge to Left Ventricular Device Implantation in Chronic Heart Failure Patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (11)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition;Precision Medicine

PHR: The microbiome has emerged as a functional microbial organ system that plays a key role in human health and disease including obesity, cancer, and inflammation. This proposal aims to revolutionize how we investigate microbial function and pave the way for the development of microbial therapies targeting specific metabolic pathways to promote health and treat disease.

PI_NAMEs: GUO, CHUN-JUN ;LONGMAN, RANDY S (contact);WRIGHT, AARON TODD

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Address;Affect;Architecture;Body System;Bypass;Characteristics;Chemistry;Clinical;Clinical Research;cohort;Complex;Data;design;Development;Diet;Dietary Factors;Dietary Fiber;Disease;Disease Outcome;Environment;Enzymes;fecal transplantation;flexibility;genetic manipulation;gut inflammation;gut microbiome;healing;Health;Health Promotion;Human;improved;Individual;Inflammation;Inflammatory Bowel Diseases;innovation;insight;Integration Host Factors;Intervention;Link;Malignant Neoplasms;Measurement;Metabolic;Metabolic Pathway;microbial;microbial composition;microbiome;microbiome composition;microbiome research;microbiome therapeutics;microbiota;microbiota transplantation;Modality;Molecular;Mucous Membrane;novel;novel strategies;Obesity;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;personalized intervention;personalized medicine;Play;Pre-Clinical Model;prebiotics;preclinical study;Process;protein function;Research;Resolution;response;Role;Shapes;Specificity;targeted treatment;Technology;Therapeutic;Therapeutic Intervention;tool;Translating;Treatment Efficacy;Treatment outcome;treatment response

PROJECT_TITLE: Activity Probes to Guide Precision Microbiome Therapy


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Pediatric;Social Determinants of Health;Women's Health Research

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative Oxytocin is a maternal hormone important for childbirth, parent-child bonding, and social cognition. However, it is unclear how, when, or where oxytocin acts in the brain to enable successful parenting and social behavior, especially if it might act in males to promote paternal behavior. The experiments to be performed in this proposal provide essential data on the action of oxytocin in the central nervous system, required for improvement of therapeutic strategies for treatment of parental neglect or other conditions relating to social interactions and childcare.

PI_NAMEs: TSIEN, RICHARD W (contact)

PROGRAM_OFFICER_NAME: GNADT, JAMES W

PROJECT_TERMS: Adult;Animals;Area;autism spectrum disorder;Axon;Behavior;Behavior monitoring;Behavioral;Brain;Caring;Cells;Central Nervous System;Child;Child Care;Child Rearing;Childbirth;Clinical;commune;Computer Models;Data;Educational process of instructing;Electrophysiology (science);Ensure;Environment;experience;experimental study;Female;Foundations;Genetic study;Home;Hormones;improved;In Vitro;in vivo;Infant;information processing;Knowledge;Life;male;Maternal Behavior;Monitor;Mothers;Mus;neglect;neural;neural circuit;Neurons;Neuropeptides;Oxytocin;Pair Bond;Parents;Paternal Behavior;Photometry;Postpartum Period;Prosencephalon;pup;sex;Signal Transduction;social;social anxiety;Social Behavior;social cognition;Social Environment;Social Interaction;Social Network;social structure;System;Temperature;Therapeutic;treatment strategy;Video Recording

PROJECT_TITLE: U19 Supplement 2023-Froemke


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: FREDERICK

ORG_NAME: BIOLOGICAL MIMETICS, INC.

PHR: Narrative  The gold standard of malaria diagnosis is microscopic analysis of Giemsa‐stained blood smears. Highly trained microscopists can detect about 3 parasites per microliter of blood. A large number of molecular diagnostics are in use and in development with varying degrees of sensitivity and quality control. PCR‐based methods can be more sensitive but require the use of relatively expensive reagents and equipment. The ability to detected low levels of parasitemia (below 3 per l) and identify the species of parasite is key to early treatment and surveillance efforts. There is a great need for inexpensive and instrument‐free diagnostics that can detect low level parasitemia. In previous studies, we have developed a multi‐chambered FAST diagnostic device that is pre‐loaded with lysis, amplification, and CRISPR/Cas12a reagents for the detection of several pathogens. The diagnostic does not require electricity, instruments, or highly trained personnel and is designed for point‐of‐care or field diagnostics. We propose to adapt this novel device for sensitive detection of malaria.

PI_NAMEs: TOBIN, GREGORY JOHN (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: 3D Print;beta Globin;Biological Assay;Blood;Blood Stains;Buffers;Chemicals;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Conserved Sequence;Cytolysis;design;Detection;Detergents;Development;Device Designs;Devices;Diagnostic;Diagnostic Equipment;Diagnostic Reagent Kits;Diagnostic tests;Digestion;DNA;Drug resistance;Dryness;Early treatment;Electricity;endonuclease;Engineering;Ensure;Equipment;Erythrocytes;Exposure to;Eye;fluorophore;Follow-Up Studies;Freeze Drying;Future;Gene Family;Genes;Giemsa stain;Guide RNA;Homologous Gene;Human;Human Resources;Individual;Infection;instrument;instrumentation;invention;isothermal amplification;Laboratories;Light;Link;Liquid substance;Malaria;Malaria Diagnosis;Malaria Diagnostic;malaria infection;manufacturing scale-up;Marketing;Medical;Methods;Microscopic;molecular diagnostics;Multigene Family;novel;novel vaccines;Nucleic Acids;Oligonucleotides;Parasitemia;Parasites;pathogen;Performance;Persons;Phase;plasmid DNA;Plasmids;Plasmodium;Plasmodium falciparum;Plasmodium ovale;Plasmodium vivax;point of care;Preparation;Process;Production;Promoter Regions;Public Health;Quality Control;Reaction;Reagent;reagent testing;Regulatory Pathway;Reporter;Resource-limited setting;Reverse Transcriptase Polymerase Chain Reaction;Ribosomes;Running;Sampling;scale up;Sensitivity and Specificity;Signal Transduction;Site;Specificity;Technology;Temperature;Testing;tool;Training;Tube;vector;Visualization;Whole Blood;Work

PROJECT_TITLE: An instrument-free malaria diagnostic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (13)]