NIH_SPENDING_CATS: Aging;Clinical Research;Comparative Effectiveness Research;Disability Research;Lung;Nutrition;Obesity;Organ Transplantation;Patient Safety;Prevention;Sarcopenia;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This proposal is focused on advancing body composition quantification of lung transplant candidates by bioelectrical impedance assay; determining the responsiveness of patient-reported survey instruments to lung transplant perioperative complications; and developing prediction models to identify which transplant recipients are at risk for poor quality of life and graft failure. This focus directly addresses areas identified by the National Heart Lung and Blood Institute as key priorities to advancing lung transplant clinical care and research.

PI_NAMEs: SINGER, JONATHAN PAUL (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Accounting;Address;Adoption;Anxiety;Area;Biolectric Impedance;Biological Assay;Body Composition;Body mass index;Body measure procedure;Cessation of life;Clinical;clinical care;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;Cognitive;Collaborations;cost;Data;Development;disability;Dual-Energy X-Ray Absorptiometry;Enrollment;Evaluation;Event;experience;frailty;Future;graft dysfunction;graft failure;graft function;Habilitation;Health;health related quality of life;Hospitalization;improved;Individual;innovation;Intervention;Intervention Studies;Intuition;Investigation;Knowledge;Length of Stay;Lung Transplantation;Mental Depression;Methods;Modality;Modeling;mortality;Multicenter Studies;Multicenter Trials;National Heart, Lung, and Blood Institute;novel;nutrition;Obesity;Observational Study;Outcome;Outcome Measure;Patient Outcomes Assessments;patient response;Patient Selection;Patient-Focused Outcomes;Patients;Perioperative;Perioperative complication;Phenotype;physical conditioning;Physical Function;post-transplant;Postoperative Period;predictive modeling;Productivity;prognostic;pulmonary function;Quality of life;Reporting;response;Risk;Risk Factors;sarcopenia;sarcopenic obesity;Scanning;Surveys;Survivors;Technology;Time;transplant centers;Transplant Recipients;Transplantation;Waiting Lists;Work

PROJECT_TITLE: The impact of body composition on peri-operative and patient-centered outcomes in lung transplantation.


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Genetics;Lung;Lung Cancer;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Progenitor cell states contributing to aging and lung cancer Narrative Aging is a primary risk factor for lung cancer, which accounts for the largest cause of cancer deaths. Cells in the lung alveoli are the source of the most common lung cancers and slowly become less functional as they age. We will use new models to investigate how molecular changes in alveolar cells contribute to cancer initiation during aging.

PI_NAMEs: HAIGIS, MARCIA  (contact);KIM, CARLA F.

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Adult;Age;age effect;age related;age related changes;aged;Aging;Alveolar;Alveolar Cell;alveolar epithelium;alveolar type II cell;Cancer Etiology;cancer initiation;cell age;Cell Aging;Cell model;Cells;Cessation of life;Cholesterol;Chromatin;Colorectal Cancer;Data;Disease;Distal;Epigenetic Process;Epithelial Cells;experience;Functional disorder;Gene Expression;Genes;Genetically Engineered Mouse;Growth;hallmarks of aging;Homeostasis;Human;Image;Impairment;in vivo Model;injury and repair;insight;Intervention;Link;Lipids;Lung;Lung Adenocarcinoma;lung cancer cell;lung development;Lung Diseases;lung injury;Lung Neoplasms;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methyltransferase;Modeling;Modification;Molecular;molecular modeling;mortality;mouse model;Mus;Natural regeneration;novel;Organoids;Pathway interactions;Persons;Population;Predisposition;prevent;Process;progenitor;Pulmonary alveolar structure;Regulation;Reporting;Resolution;Respiratory physiology;Risk Factors;Role;self renewing cell;single cell sequencing;Smoking;Source;stem cell biology;stem cell function;stem cells;Steroids;Study models;synergism;System;Technology;Testing;tumor;tumor initiation;tumor metabolism;tumor progression;tumorigenesis


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Recent advances in single cell assays have enabled the genome-wide profiling of tens-of-thousands of individual cells from a single tissue sample, however, the significant sparsity and noise of single cell measurements means that analysis of this data is typically performed at the level of large groups or clusters of cells. Unfortunately, cluster-based results reflect the state of the average cell in the cluster, which may be quite dissimilar from many cells in heterogeneous populations. To address this limitation, we will create innovative gene set-based methods that estimate cell type, phenotype and interaction potential for individual cells rather than cell groups.

PI_NAMEs: FROST, HILDRETH  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Algorithms;Bioinformatics;Biological;Cell Communication;Cell Separation;cell type;Cells;Cellular Assay;Chromatin;Complex;Data;Data Analyses;DNA Sequence;Genes;Genetic Transcription;genome-wide;genomic data;Immune;Immune response;Individual;innovation;insight;Malignant Neoplasms;Measurement;Methods;Noise;Pathway Analysis;Pathway interactions;Phenotype;Population Heterogeneity;Proteins;Research Personnel;Signal Transduction;single cell analysis;single cell genomics;Statistical Data Interpretation;Structure;Techniques;Testing;Tissue Sample;Tissues;tool;translational applications;tumor microenvironment

PROJECT_TITLE: Gene set analysis of single cell genomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)R]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative This U24 application represents our continued participation in ClinGen Consortium. ClinGen develops structured frameworks for curation of gene, variant and actionability relevant to human disease and the Baylor College of Medicine/Stanford University teams has developed robust web-based software infrastructure to support these ClinGen’s efforts as well as supporting highly successful and innovative expert panels for hereditary cancer, complex disease and ancestry and diversity.

PI_NAMEs: KLEIN, TERI ELLEN;MILOSAVLJEVIC, ALEKSANDAR ;PLON, SHARON E. (contact);WRIGHT, MATT WILLIAM

PROGRAM_OFFICER_NAME: MINEAR, MOLLIE A

PROJECT_TERMS: Achievement;Adult;Alleles;Autoimmune Diseases;Automation;base;Childhood;Classification;Clinical;clinically relevant;Code;college;Communities;Complex;Consumption;Data;data hub;data modeling;Data Set;data sharing;Databases;design;Development;Diagnostic;Disease;diverse data;Ecosystem;Education;empowerment;Ensure;Ethnic Origin;FAIR principles;forging;Gene Frequency;Genes;genetic variant;Genome;genome resource;genomic data;Genomic medicine;Genomics;Genotype;Goals;Guidelines;Hereditary Malignant Neoplasm;human disease;Human Genetics;Human Genome;improved;Informatics;Infrastructure;Inherited;innovation;Institution;International;Internet;interoperability;Knowledge;knowledge curation;knowledgebase;Lead;Link;Literature;Malignant Neoplasms;Measures;Medical Genetics;Medicine;member;Modeling;novel;outreach;Participant;phenotypic data;Pilot Projects;Policies;polygenic risk score;Population Heterogeneity;Procedures;Process;programs;Race;Registries;Research;Research Proposals;Resources;response;Rheumatism;Risk;scale up;software infrastructure;software systems;Source;Specific qualifier value;Structure;Technology;tool;tool development;Training;Training and Education;trustworthiness;Universities;Untranslated RNA;Variant;web based software;web site;Work;working group

PROJECT_TITLE: Baylor College of Medicine/Stanford University Clinical Genome Resource (CLINGEN)


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Diabetes;Genetics;Heart Disease;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: FARMINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE Individuals with Type 2 diabetes (T2DM) are more than twice as likely to die from cardiovascular disease, even when blood sugar and cholesterol levels are well-controlled. I have identified a unique genetic network in white blood cells from people with T2DM and cardiovascular disease, and I will use computer modeling to determine how much this genetic network contributes to cardiovascular disease risk. In the future, this could help us better understand the causes of cardiovascular disease, design new treatments to prevent disease, and predict who is at the highest risk for cardiovascular disease.

PI_NAMEs: KARLINSEY, KEATON  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;Affect;Algorithms;Atherosclerosis;Biological;Biology;Blood Glucose;blood glucose regulation;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career;Cholesterol;Chronic;Chronic Disease;Clinical;Clinical Data;clinical predictive model;cohort;Computer Models;Connecticut;Data;Data Set;design;Diabetes Mellitus;differential expression;Disease;Disease Outcome;efficacy evaluation;Environment;Equation;Event;feature selection;Foam Cells;follow-up;Future;gene network;Genes;Genetic;genetic signature;Genetic Transcription;glycemic control;Goals;high risk;Immunologics;improved;Individual;Inflammation;Inflammatory;innovation;Intervention;Knowledge;Leukocytes;Lipids;machine learning algorithm;medical schools;Metabolic Diseases;model development;Modeling;Modernization;Molecular Profiling;monocyte;multi-ethnic;NCOR2 gene;next generation;Noise;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Output;Pathogenesis;Pathogenicity;Pathology;Pathway Analysis;Pathway interactions;Patients;Performance;Persons;Physicians;Play;predict clinical outcome;predictive modeling;prevent;Proteins;Publications;Risk;Risk Assessment;Risk Factors;Role;Sampling;Scientist;Ski-interacting protein;skills;SNW1 Gene;standard of care;supervised learning;Testing;tool;Training;training data;transcriptomics;Universities;Virulence Factors

PROJECT_TITLE: Predicting Cardiovascular Outcomes Using Diabetes-Induced Transcriptomic Networks


ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Recently, we have demonstrated that patients with heart failure and preserved ejection fraction (HFpEF) with comorbid obesity have striking depression of right ventricular myocyte calcium activated force, with force negatively correlating with BMI. This finding has clinical implications, suggesting that the selective use of small molecule sarcomere enhancers might benefit patients with obese HFpEF. In this proposal, I aim to elucidate the mechanism of obesity mediated myocyte dysfunction, specifically exploring the impact of obesity on both the thick and thin filament in HFpEF.

PI_NAMEs: JANI, VIVEK PINAKIN (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Actins;Affect;Basic Science;Biological Assay;Biomechanics;Biopsy;Body mass index;Calcium;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;career;Cells;Clinical;comorbidity;Complex;Data;Depressed mood;Disease;effective therapy;EFRAC;Enhancers;Enzymes;Exhibits;Exposure to;Filament;Freezing;Functional disorder;Future;Generations;Goals;Head;Heart failure;heart preservation;Human;Hypertension;Hypertrophy;Label;Laboratories;Link;Location;Measures;Mediating;Medicine;Mental Depression;Metabolic syndrome;Microfilaments;mimetics;Molecular Biology Techniques;Molecular Conformation;Morbidity - disease rate;Muscle Cells;Mutagenesis;Myocardium;Myosin ATPase;Myosin Type I;novel;novel strategies;novel therapeutics;obese patients;Obesity;pandemic disease;Patients;Pattern;Phenotype;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physicians;Physiologic pulse;Positioning Attribute;preservation;Production;Protein Kinase C;Protein phosphatase;Protein-Serine-Threonine Kinases;Proteins;Relaxation;Reporting;Research;Role;Sarcomeres;Scientist;Serine/Threonine Phosphorylation;Site;skills;Skin;small molecule;Structure;Synchrotrons;Syndrome;systolic hypertension;Techniques;Test Result;Testing;Thick;Thick Filament;Thin Filament;Thinness;Threonine;Training;Transgenic Organisms;Tropomyosin;Troponin;Troponin I;Ventricular;Work;X ray diffraction analysis

PROJECT_TITLE: Thick and Thin Filament Dysfunction in Obese Heart Failure with Preserved Ejection Fraction


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering;Cardiovascular;Clinical Research;Machine Learning and Artificial Intelligence;Precision Medicine

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative/Public Health Relevance The importance of understanding hemodynamic profiles in treating vascular disease is now well established, and techniques to derive key parameters at single time points are rapidly being adopted in the clinic. Despite this, the field lacks coherent, realtime, and non-invasive methods to identify 3D profiles over time, or how they can be used to guide treatment. The proposed project will develop a novel, physiologically-aware learning method by which 3D flow fields can be derived on a patient-specific bases, and thus, has broad implications for vascular disease therapy

PI_NAMEs: RANDLES, AMANDA E (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: 3-Dimensional;Adopted;Awareness;base;Cardiovascular Diseases;Cardiovascular Models;Cardiovascular system;Clinic;Complex;Coupling;Data;digital twin;hemodynamics;improved;Intervention;learning strategy;Machine Learning;Methodology;Methods;Modeling;Monitor;novel;Patients;Pattern;personalized predictions;Physics;Physiological;precision medicine;prevent;public health relevance;real time monitoring;screening;simulation;Stimulus;Stream;Techniques;Time;treatment planning;Vascular Diseases;Vascular System;wearable device;wearable sensor technology

PROJECT_TITLE: Dynamic models of the cardiovascular system capturing years, rather than heartbeats


ADMINISTERING_IC: AI

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_STATE: CA

PHR: PROJECT NARRATIVE The restructured UCSF-Bay Area CFAR is dedicated to promoting multidisciplinary research addressing cutting-edge questions in HIV/AIDS biology, treatment, and prevention. This approach from UCSF has led to breakthrough discoveries advancing patient care and providing new approaches to curbing the HIV pandemic both locally and internationally. CFAR is also committed to supporting the next generation of HIV researchers, international research, health equity, and community engagement, all of which are critical for truly ending the HIV epidemic.

PI_NAMEs: GANDHI, MONICA  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Advocacy;Area;Basic Science;Behavior;Behavioral Research;biobehavior;Bioinformatics;Biological Markers;Biological Specimen Banks;Biology;Biometry;career;career development;Cities;Clinic;Clinical;clinical care;Clinical Research;co-infection;cohort;Collaborations;Communication;Communities;community engagement;comorbidity;computerized data processing;Dedications;Development;Educational workshop;Epidemic;Evaluation;Event;experience;Fostering;Foundations;functional genomics;Goals;Grant;health equity;HIV;HIV/AIDS;Housing;Immunology;implementation science;improved;Inflammation;Infusion procedures;innovation;Institution;Interdisciplinary Study;International;intersectionality;Laboratories;Leadership;Measures;meetings;Mentors;Methods;minority investigator;Monitor;multidimensional data;multidisciplinary;Multiomic Data;Names;National Institute of Allergy and Infectious Disease;next generation;novel;novel strategies;Outcome;pandemic disease;Participant;Pathogenesis;Patient Care;Pharmacology;Positioning Attribute;pre-exposure prophylaxis;Prevention;Productivity;programs;Prospective cohort;referral services;Research;Research Personnel;Resources;response;Risk;social;Specimen Handling;structural determinants;structural health determinants;substance use;Training;Translational Research;Underrepresented Minority;United States National Institutes of Health;Visualization;Vulnerable Populations;ward;Work;working group

PROJECT_TITLE: UCSF-Bay Area Center for AIDS Research


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Area;base;Basic Science;behavioral and social science;biobehavior;Bioinformatics;Biometry;Cancer Center;Clinical Sciences;Collaborations;Communication;Communities;community advisory board;community collaboration;community engagement;community organizations;County;Decision Making;Development;Discipline;Doctor of Philosophy;Ensure;Focus Groups;Funding;global health;Grant;Health;health disparity;health equity;Health Sciences;HIV;Housing;implementation science;improved;Inflammation;Institution;Interdisciplinary Study;interest;Interest Group;International;intersectionality;Joints;Leadership;Measures;member;minority investigator;Monitor;multidisciplinary;multiple omics;National Institute of Allergy and Infectious Disease;Paper;Positioning Attribute;Prevention;Process;Productivity;Program Evaluation;programs;Publications;Research;Research Institute;Research Personnel;Resources;San Francisco;Science;Secure;Series;Services;sound;Source;Strategic Planning;success;Surveys;symposium;Training;Translational Research;Underrepresented Minority;United States National Institutes of Health;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Lung

ORG_CITY: STONY BROOK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: PROJECT NARRATIVE Dysfunctions in airway motile cilia, hair-like organelles that line the respiratory tract, are implicated in pulmonary disorders such as SARS-CoV2 infection, as well as ciliopathies that have devastating effects on multiple organ systems; however, although cilia play an integral role in airway innate immunity, the biological processes underlying the formation and maintenance of these organelles are still poorly understood. While the unique shape and lipid composition of the ciliary membrane is thought to contribute to cilium homeostasis, it is still unclear how the ciliary membrane is assembled and maintained during and after cilia formation. My research will provide new insight into the mechanisms that drive ciliary membrane shaping and maintenance by investigating the roles of the membrane-binding ciBAR proteins in ciliogenesis and airway ciliated cell differentiation, thus furthering our current understanding of the biology of cilia and ciliopathies.

PI_NAMEs: KIM, EUNICE NA YOUNG (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Address;Affect;Age;amphiphysin;Antibodies;Apical;apical membrane;base;Binding;Binding Proteins;Biochemical;Biogenesis;Biological;Biological Models;Biological Process;Biology;Biosensor;Body System;Cell Differentiation process;Cell membrane;Cell surface;Cells;Centrioles;Chronic;Chronic lung disease;Cilia;ciliopathy;cilium biogenesis;cilium motility;clinical phenotype;Complex;Data;Defect;Defense Mechanisms;Development;dimer;Dimerization;Disease;Distal;DNA Sequence Alteration;Docking;Endocytosis;Epithelial Cells;Exhibits;Functional disorder;Goals;Hair;Histology;Homeostasis;Human;Immunofluorescence Immunologic;Impairment;In Vitro;in vitro Assay;in vivo;Inhalation;insight;kinetosome;Knockout Mice;Knowledge;Label;Laboratories;Link;Lipids;Liposomes;Literature;loss of function;Lung;Lung Diseases;Maintenance;Mammalian Cell;Mediating;Membrane;membrane assembly;Membrane Lipids;Methods;Microtubules;Molecular;Morphology;mouse model;Mucociliary Clearance;Mucous body substance;Mus;Natural Immunity;novel;Organ;Organelles;pathogen;Patients;Pharmaceutical Preparations;Phenotype;Phospholipids;Physiological;Play;Preventive treatment;Primary Cell Cultures;Process;Property;Proteins;recruit;Reporting;Research;Respiration Disorders;Respiratory System;Role;SARS-CoV-2 infection;Scanning Electron Microscopy;Sedimentation process;Shapes;Stains;Structure;symptom treatment;System;Tertiary Protein Structure;Testing;Trachea;Tracheal Epithelium;Transmission Electron Microscopy;Vesicle;wasting

PROJECT_TITLE: Elucidating the Roles of the Membrane-Binding Proteins ciBAR1 and ciBAR2 in Ciliogenesis


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PI_NAMEs: JOHNSON, MALLORY O (contact)

PROJECT_TERMS: Academia;Acquired Immunodeficiency Syndrome;Address;Advocacy;Advocate;Affect;Applications Grants;Area;Automobile Driving;Award;Basic Behavioral and Social Science Research;career;career development;career life balance;Clinical;Collaborations;Communication;Communities;Dedications;Development;Direct Costs;Discipline;Distress;Doctor of Philosophy;Educational workshop;Enrollment;Epidemic;Equipment;equity, diversity, and inclusion;Evaluation;experience;Faculty;Feedback;Fostering;Funding;Funding Mechanisms;Future;Grant;hands-on learning;HIV;HIV/TB;Individual;innovation;Institution;International;intersectionality;Investments;Leadership;Lightning;Mediation;meetings;member;Mentors;microaggression;mid-career faculty;migration;minority investigator;minority trainee;Mission;multidisciplinary;Outcome;peer;Peer Review;peer support;Play;Positioning Attribute;Postdoctoral Fellow;Preparation;Productivity;programs;Publications;recruit;Research;research and development;Research Institute;Research Personnel;Resources;Role;Scientist;Secure;skills;success;symposium;Teacher Professional Development;Techniques;tool;Training;Travel;unconscious bias;Underrepresented Minority;United States National Institutes of Health;Work;working group;Writing

PROJECT_TITLE: Developmental Core


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: NARRATIVE Age-related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP) are caused by loss of rod and cone photoreceptor cells, but other retinal also show changes, including the emergence of hyperactivity in many retinal ganglion cells (RGC). We recently discovered that retinoic acid (RA) is the signal that triggers RGC hyperactivity and that blockers of RA unmask light responses in RGCs that would otherwise be obscured. In this project, we will explore whether drugs or genes that inhibit either the production or action of RA can improve conscious vision in a mouse model of RP, providing a new strategy for enhancing low vision in human blinding disorders.

PI_NAMEs: KRAMER, RICHARD H (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Ablation;Acute;Age related macular degeneration;Alcoholism;Amacrine Cells;Animal Model;avoidance behavior;Behavior;behavior test;Behavioral;Blindness;Brain;Cells;cellular targeting;Chemicals;Clinical Research;Conscious;Contrast Sensitivity;Darkness;Degenerative Disorder;Deterioration;Disease;Dissociation;Disulfiram;Dominant-Negative Mutation;drug repurposing;Electrophysiology (science);Enzyme Inhibition;Enzymes;experimental study;FDA approved;Frequencies;Functional disorder;Gene Expression;gene therapy;gene-targeted therapy;Generations;Genes;Genetic Transcription;Goals;Histologic;Human;Hyperactivity;Impairment;improved;in vivo;Individual;inhibitor;Interneurons;Light;Light Cell;Measures;Morphology;mouse model;multi-electrode arrays;Mus;Neurons;optogenetics;patch clamp;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Photophobia;photoreceptor degeneration;Photoreceptors;presynaptic neurons;Process;Production;Proteins;Reporter;Reporting;response;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;Retinitis Pigmentosa;Retinoic Acid Receptor;safety assessment;safety testing;Signal Pathway;Signal Transduction;small molecule;spatial vision;Synapses;Synaptic Transmission;Testing;Tetracyclines;Therapeutic;Time;Toxic effect;Training;Transgenic Mice;translation to humans;transmission process;Tretinoin;Vertebrate Photoreceptors;Viral;Vision;Visual;Visual impairment;visual information;visual learning

PROJECT_TITLE: Targeting the retinoic acid signaling pathway for mitigating visual impairmen in retinal degenerative disorders

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: DEEKS, STEVEN GRANT (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;African American;AIDS clinical trial group;antiretroviral therapy;Area;Asian;base;behavioral study;bench-to-bedside translation;biobehavior;Biological Specimen Banks;career;Clinic;Clinical;Clinical Data;Clinical Research;Clinical Sciences;cohort;Communities;comorbidity;Consumption;cost efficient;Data;Databases;design;Development;Discipline;dissemination science;Enrollment;ethnic diversity;Funding;General Hospitals;health equity;Health Priorities;HIV;HIV Seronegativity;Human;human subject;Human Subject Research;Immunology;implementation science;improved;Infrastructure;innovation;International;Investigation;Investments;Latinx;Manuscripts;marginally housed;Mentors;Methodology;microbiome;multi-racial;multidisciplinary;Names;novel;Participant;Pathogenesis;Patients;Peer Review;Persons;Population;Population Sciences;Prevention;Process;programs;prospective;Prospective cohort;Publications;Publishing;racial diversity;Recording of previous events;recruit;referral services;Research;Research Personnel;research study;Research Support;Risk;San Francisco;Sapphire;Services;socioeconomics;Specimen;Specimen Handling;System;Time;Training;Translational Research;translational study;transmission process;Underrepresented Populations;Uninsured;United States National Institutes of Health;Viral;Vulnerable Populations;ward

PROJECT_TITLE: Clinical Core


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Nutrition;Obesity;Physical Activity;Prevention;Sleep Research

ORG_CITY: LAS VEGAS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: Project Narrative Cardiovascular disease is the leading cause of death and is exacerbated by circadian rhythm disruption. We will test the effects of social jetlag, a pervasive form of circadian rhythm disruption driven by shifting behaviors between weekdays and weekends, on the susceptibility of developing cardiovascular disease in mice. Additionally, we will examine how exercise prescribed at specific times of day may alleviate the consequences of social jetlag.

PI_NAMEs: MCGINNIS, GRAHAM RIPLEY (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Acceleration;Acute;Address;Attenuated;Back;Behavior;Behavioral;Body Weight;Cardiometabolic Disease;cardiometabolism;cardiorespiratory fitness;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular fitness;Cardiovascular Pathology;cardiovascular risk factor;Cardiovascular system;Cause of Death;Chronic;circadian;circadian behavioral rhythms;Circadian Rhythms;Clinical;combat;Cross-Sectional Studies;Darkness;Data;Development;Diabetes Mellitus;Diet;Dietary Intervention;Disease;Disease susceptibility;efficacy evaluation;Exercise;exercise capacity;exercise intervention;exercise prescription;exercise training;experience;Exposure to;Fatty acid glycerol esters;feeding;Female;Fibrosis;fitness;Functional disorder;Funding;Gene Expression;Genetic;Genetic Transcription;Glucose;Goals;Health;Heart;Hour;Impairment;improved;Individual;Inflammation;innovation;insight;Insulin Resistance;Intervention;Jet Lag Syndrome;Light;Literature;male;Metabolic;Metabolic Diseases;Metabolic stress;Modeling;Modernization;Molecular;Molecular Analysis;Monitor;Mus;Myocardial;Myocardium;novel;Obesity;obesity prevention;Pathology;Pattern;Phase;Physical activity;Physiological;Physiology;Play;Population;Predisposition;preference;preservation;prevent;Prevention;Research;response;Role;Running;Schedule;Schools;sedentary;sensor;Signal Transduction;Skeletal Muscle;social;Societies;Stress;Students;Testing;Time;Tissues;Training;training opportunity;Translating;Treadmill Tests;VO2max;western diet;Work

PROJECT_TITLE: Effects of time-of-day dependent exercise training on social jetlag induced susceptibility to cardiometabolic disease


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Data Science;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PI_NAMEs: HUNT, PETER W (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Aging;Anti-Retroviral Agents;apprenticeship;Area;aspirate;assay development;Award;Basic Science;Behavior;biobehavior;Bioinformatics;Biological Markers;Biopsy;career development;Cells;Cellular biology;Clinical;co-infection;cohort;Communities;community collaboration;community engagement;comorbidity;computerized data processing;Consultations;Data;Data Analyses;data library;Data Science;Dedications;Development;Drug Interactions;Drug Kinetics;Ensure;Equity;Flow Cytometry;Focus Groups;functional genomics;Funding;Group Meetings;high dimensionality;HIV;HIV therapy;human tissue;Image;Immune;Immunology;Immunology procedure;in vivo;Individual;Inflammation;instrumentation;Interdisciplinary Study;interest;Interest Group;International;Intervention;Leadership;Leukapheresis;lymph nodes;Measurement;Measures;Mentors;Mentorship;Modeling;multidimensional data;multidisciplinary;Multiomic Data;multiple omics;Pathogenesis;Peer Review;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology;Positron-Emission Tomography;pre-exposure prophylaxis;Procedures;Process;Productivity;programs;Publications;Research;Research Personnel;Research Project Grants;research study;Resources;Sampling;Services;single-cell RNA sequencing;Sorting;Specimen;Strategic Planning;Time;Tissues;Training;Translational Research;translational scientist;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: Basic and Translational Science Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The Neuroscience Roadmap Scholars Program at the University of Alabama at Birmingham focuses on increasing diversity in the neuroscience workforce through providing outstanding educational support, training, and professional development for neuroscience doctoral student trainees. This enhanced support for these qualified and talented under-represented trainees will provide the skills needed to increase future academic leaders in the neurosciences.

PI_NAMEs: LUBIN, FARAH DOMINIQUE (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Academic support;Acceleration;Affect;African American;Alabama;Award;Awareness;Back;Basic Science;Black race;Brain Diseases;bridge to the doctorate;career;Career Choice;Clinical;Communication;Communities;Country;Critical Thinking;Dedications;Development;disability;disabled students;Discipline;Distance Learning;diversity and inclusion;Doctor of Philosophy;Doctor's Degree;doctoral student;Education;Educational process of instructing;Educational workshop;Enrollment;Environment;Equity;equity, diversity, and inclusion;Evaluation;experience;Experimental Designs;Extramural Activities;Faculty;Fellowship;First Independent Research Support and Transition Awards;flexibility;foot;forging;Fostering;Funding;Future;General Population;Goals;graduate student;Grant;Growth;Hispanic;Home;Individual;Industry;Infrastructure;innovation;Investments;Journals;Latino Population;Leadership;Learning;Location;Manuscripts;matriculation;medical schools;meetings;member;Mentors;Mentorship;Minority Groups;Mission;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurosciences;Neurosciences Research;Oral;Outcome;peer;peer coaching;Population Heterogeneity;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;professor;programs;Puerto Rico;Qualifying;Readiness;Reporting;Research;Residencies;resilience;Scholars Program;Schools;Science;Scientist;Secure;Services;skills;Social support;Societies;Strategic Planning;Structure;student training;Students;success;supportive environment;symposium;Talents;Time;Time Management;tool;Training;Training Support;undergraduate student;Underrepresented Minority;Underrepresented Students;United States;United States National Institutes of Health;Universities;Woman;Workplace;Writing

PROJECT_TITLE: UAB Neuroscience Roadmap Scholars Program


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;AIDS prevention;Alcohol consumption;antiretroviral therapy;Area;Behavior;Behavioral;Behavioral Research;biobehavior;Biological Assay;Biological Markers;Blood;career development;Caring;Clinical;Clinical Data;Clinical Research;Cocaine;cohort;Collaborations;Communities;community engagement;Consultations;Data;Data Element;data infrastructure;Development;disparity reduction;Doctor of Philosophy;Dryness;Ensure;Epidemic;Focus Groups;Hair;health disparity;health equity;Health Priorities;Heroin;HIV;Housing;Individual;Infrastructure;Injectable;innovation;Interest Group;International;intersectionality;Intervention;Maintenance;Measurement;Measures;Mentors;Methamphetamine;Methods;National Institute of Mental Health;Oral;Outcome;Participant;Persons;Pharmaceutical Preparations;Pharmacy Schools;phosphatidylethanol;Pilot Projects;point of care;Policies;Population;Positioning Attribute;pre-exposure prophylaxis;Prevention;Process;Productivity;programs;Public Health;public health research;Research;Research Personnel;Research Priority;research study;Resources;San Francisco;School Nursing;Severities;social;Specimen;Spottings;Strategic Planning;structural health determinants;Students;substance use;Surveys;synergism;Tenofovir;Time;Training;training opportunity;Underrepresented Minority;United States National Institutes of Health;Urine;Work;working group

PROJECT_TITLE: Bio-Behavioral Core


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: SEVELIUS, JAE M. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Applications Grants;Area;Behavior;biobehavior;Biological Markers;Black race;career;Caring;catalyst;Categories;cohort;Collaborations;Communication;Communities;community building;community engaged research;community partners;Development;Director's Working Group;Discipline of Nursing;Doctor of Philosophy;Educational workshop;Ethnic Origin;experience;Feedback;Funding;Funding Opportunities;Gender;Goals;Group Meetings;Health;Health Disparities Research;health disparity;health inequalities;HIV;HIV disparities;Housing;Humanities;Individual;Inequity;interest;International;intersectionality;Intervention;investigator training;Journals;Knowledge;Leadership;Learning;lens;marginalization;marginalized population;Measurement;Measures;Medicine;meetings;member;Mentors;Mentorship;Methods;multidisciplinary;National Institute of Mental Health;NIH Office of AIDS Research;novel;Outcome;Persons;Positioning Attribute;pre-exposure prophylaxis;Prevention;profession allied to medicine;programs;Public Health;public health research;Publications;Race;racism;Research;Research Design;Research Personnel;Resources;Scientist;Sex Orientation;Sexism;social;social disparities;Social Sciences;social stigma;social structure;sociodemographics;Socioeconomic Status;Structure;substance use;System;Time;Training;Underrepresented Minority;United States National Institutes of Health;Work;working group;Writing

PROJECT_TITLE: Intersectionality Scientific Working Group


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: RILEY, ELISE D. (contact)

PROJECT_TERMS: Academia;Acceleration;Acquired Immunodeficiency Syndrome;Address;Advocate;AIDS prevention;Area;barrier to testing;biobehavior;California;career development;Caring;Case Management;Collaborations;Communities;community engagement;Community of Practice;community partners;comorbidity;Country;Development;Director's Working Group;Discipline;Disparity;Doctor of Philosophy;Educational workshop;Environment;Epidemic;Event;experience;Failure;food insecurity;Fostering;Funding Opportunities;Goals;Health;health care delivery;health equity;Healthcare;HIV;HIV diagnosis;HIV disparities;HIV Infections;Homelessness;Housing;housing instability;implementation science;Imprisonment;improved;Incidence;Individual;Inequity;insight;Interdisciplinary Study;Interest Group;International;intersectionality;Intervention;Investigation;knowledge base;Link;Low Income Population;marginally housed;member;Mental Depression;Mentors;Methodology;migration;Mission;multidisciplinary;next generation;novel;novel strategies;Outcome;Persons;Policy Maker;Population;Post-Traumatic Stress Disorders;pre-exposure prophylaxis;Prevention;Primary Care;programs;Public Health;racism;Research;Research Personnel;Research Project Grants;response;Risk;Risk Factors;San Francisco;Science;Services;severe mental illness;social;social stigma;substance use;symposium;synergism;Testing;Training;Treatment outcome;uptake;Violence;Viral;Viral Load result;Woman;Work;working group

PROJECT_TITLE: Housing Scientific Working Group


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_DEPT: UROLOGY

PHR: PROJECT NARRATIVE In this career development program, the University of California, San Francisco (UCSF) and Kaiser Permanente Northern California (KPNC) will provide rigorous interdisciplinary training and robust career development support to junior faculty developing research programs in urological epidemiology. Our leadership and faculty at UCSF and KPNC have a superb track record of producing accomplished, independent scientists in urology, epidemiology, and related fields. This program will leverage the unique environment of KPNC, a large learning health care system with a diverse population and extensive electronic clinical data, numerous prospective cohorts, and the rich investigative and educational resources of UCSF to develop emerging leaders in epidemiology of non-malignant urology conditions.

PI_NAMEs: HUANG, ALISON  (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: Area;California;career;career development;certificate program;clinical practice;Collaborations;Data;data resource;Data Set;Degree program;Doctor of Philosophy;Environment;Epidemiology;epidemiology study;experience;Faculty;Funding;Future;Growth;hands on research;Individual;Infrastructure;innovation;Institution;Integrated Health Care Systems;Interdisciplinary Study;Investments;Learning;Life;Mentored Clinical Scientist Development Program;Mentors;Methodology;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Malignant;patient population;Patients;Productivity;Program Development;programs;Public Health;Publications;Recording of previous events;Research;Research Methodology;Research Personnel;Research Training;Resources;San Francisco;Series;skills;Structure;success;Training;Training Programs;United States National Institutes of Health;Universities;urologic;Urology

PROJECT_TITLE: UCSF-Kaiser Urological Epidemiology Research Career Development Program

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative: This project leverages a well-established in vivo mammalian system to study how precise epigenic remodeling enables Primordial Germ Cells (PGCs) to differentiate into cells capable of generating gametes. A greater understanding of the epigenetic processes governing this critical developmental stage can be leveraged to advance in vitro gametogenic technologies. The results of this project will advance our understanding of developmental epigenetic contributions to adult fertility.

PI_NAMEs: DIRUSSO, JONATHAN ADAM (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Adult;ATAC-seq;Automobile Driving;Binding;Binding Sites;Biological;cell determination;Cell Differentiation process;Cell model;Cell Nucleolus;Cells;Chemicals;Chromatin;Clinical;Competence;conditional knockout;Couples;Data;Development;DNA;DNA Transposable Elements;DNase I hypersensitive sites sequencing;Elements;Embryo;embryo cell;Embryonic Development;Endogenous Retroviruses;Endowment;Enhancers;Epigenetic Process;epigenome;Event;experimental study;Failure;Fertility;fitness;Gametogenesis;Gene Expression;Genes;Genetic;Genome;genome-wide;Germ Cells;Germ Lines;Gonadal Ridge;Gonadal structure;Heterochromatin;histone modification;Human;In Vitro;in vivo;Infertility;insight;interest;Knockout Mice;Licensing;Link;Long Terminal Repeats;Maintenance;Maps;Mediating;migration;Modeling;Molecular;Morphology;mouse model;Mus;NPM1 gene;nucleolin;Phenocopy;pluripotency;pluripotency factor;Pluripotent Stem Cells;Process;Production;programs;Proliferating;promoter;Publishing;Regulation;Ribosomal RNA;Ribosomes;RNA Polymerase I;RNA Polymerase Inhibitor;Role;Scaffolding Protein;sex;Site;Specific qualifier value;stem cells;Structure;Structure of primordial sex cell;System;Technology;Testing;Time;transcription factor;Transcriptional Silencer Elements;transcriptome sequencing;transcriptomics;Up-Regulation;Work

PROJECT_TITLE: Molecular Mechanisms Guiding TRIM28 Contribution to Determination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-L(20)L]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: LINCOLN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Project Narrative Alcohol-involved sexual violence (SV) is a major public health issue among young adult women, leading to harmful impacts on survivors’ mental and physical health. Most survivors disclose their SV experiences to informal support providers who often respond with negative reactions that hinder survivors' natural recovery. Findings from this study will illuminate the content of survivors' disclosures, which can be used to develop interventions to prevent negative responses from support providers, thus facilitating survivors' natural recovery.

PI_NAMEs: EDWARDS, MADISON  (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Adherence;Adult;Adult women;Age;aged;Alcohol consumption;alcohol involvement;Alcohols;assault;coping;Data;Disclosure;Distress;drinking;Educational process of instructing;Elements;Event;experience;Family;Friends;high risk drinking;Impairment;in vivo;informal support;Intervention;Interview;Intoxication;Knowledge;Label;Language;Link;Literature;Mediator;Mental Depression;Mental Health;Methods;Nature;Outcome;Participant;Perception;physical conditioning;Post-Traumatic Stress Disorders;prevent;Process;Provider;psychosocial outcome;Public Health;Reaction;Recovery;Reporting;Research;response;revictimization;Risk;Sampling;sexual assault;sexual violence;Shapes;social;substance use;Survey Methodology;Surveys;Survivors;Testing;theories;Time;Victimization;Woman;women's outcomes;Work;young adult;young woman

PROJECT_TITLE: The Process of Alcohol-Involved Sexual Assault Disclosure:  A Mixed-Methods Approach to Examining Disclosure Content


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Overuse of cervical cancer screening is a pressing and widespread public health problem in the United States. While several strategies have been shown to be effective for increasing cervical cancer screening, it is largely unknown how best to decrease overscreening in routine care. By testing the effectiveness of patient and clinician de-implementation strategies, the proposed study will yield fundamental knowledge about how to reduce unnecessary harms of overscreening that can be implemented into diverse settings and translated to reduce other forms of low-value care across the cancer control continuum and beyond.

PI_NAMEs: RENDLE, KATHARINE A. (contact)

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Address;Age;age group;aged;Appointment;Awareness;Behavior;Behavioral;Belief;Cancer Center;Cancer Control;Caring;Cervical;Cervical Cancer Screening;Clinic;Clinical;clinical care;cohort;Complex;Consensus;Consolidated Framework for Implementation Research;contextual factors;cost;COVID-19 pandemic;Data;Deimplementation;design;Diagnostic Procedure;Effectiveness;effectiveness testing;Electronic Health Record;Ensure;Equilibrium;Equity;Evaluation;evidence based guidelines;Failure;Female;Financial cost;Guideline Adherence;Guidelines;Gynecology;Health system;Healthcare Systems;Heterogeneity;High grade dysplasia;Hybrids;implementation cost;implementation outcomes;implementation science;implementation strategy;implementation trial;Information Technology;innovation;Interview;Knowledge;Laboratories;Malignant neoplasm of cervix uteri;Measurement;Measures;Medical;medical specialties;Methods;Modeling;Motivation;National Cancer Institute;opportunity cost;organizational climate;Outcome;Pathway interactions;patient-clinician communication;Patients;point of care;Population Heterogeneity;Primary Care;psychosocial;Public Health;Publishing;Race;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reporting;Research Design;Risk;routine care;Sampling;Scientist;screening;sex;Shapes;Stimulus;success;Surveys;Testing;Theoretical model;theories;Touch sensation;Translating;treatment as usual;United States;unnecessary treatment;Work

PROJECT_TITLE: De-Implementation of Low-Value Cervical Cancer Screening

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

PHR: NARRATIVE Tick-borne rickettsial infections cause significant morbidity and mortality in healthy individuals as the natural habitat of the vector continues to expand in the United States; however, vaccines for tick-borne rickettsial infections are not available. To address this critical need, this proposal will reveal the molecular basis for protective immunity against tick-borne rickettsioses and determine the vaccine efficacy of the O-antigen conjugate vaccine and O-antigen-specific (Weil–Felix) monoclonal antibodies. !

PI_NAMEs: KIM, HWAN KEUN  (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Active immunity;adaptive immune response;Address;Anabolism;Anaplasmosis;Annual Reports;Antibiotic Therapy;Antibiotics;Antibodies;antibody detection;Antigens;arthropod-borne;Attenuated;Attenuated Vaccines;Babesiosis;Bacteria;Bacterial Attachment Site;Bacterial Infections;bactericide;Blood Vessels;Boutonneuse Fever;Carbohydrates;Case Study;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;chemical synthesis;Chemicals;Clinical;Conjugate Vaccines;cross reacting material 197;Cross Reactions;cross reactivity;Data;Defect;Development;Diagnosis;Diagnostic tests;Disease;Doxycycline;egg;Ehrlichiosis;Endothelial Cells;Enzymes;Epidemic;Exhibits;FDA approved;Formalin;Generations;Genes;Genetic study;Goals;Habitats;Health;HK2 gene;Human;Immune;Immune response;Immune Sera;Immunity;Immunization;In Vitro;in vitro Assay;Inactivated Vaccines;Incidence;Individual;Infection;Invaded;Knowledge;Laboratories;Life Cycle Stages;Lipopolysaccharides;Lyme Disease;Mediating;microorganism;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mus;Mutagenesis;mutant;O Antigens;Operon;Outcome;Passive Immunity;pathogen;Pathogenesis;Pathogenicity;Pathology;Patients;Phenols;Polysaccharides;Preventive;protective efficacy;Proteus vulgaris;Public Health;Publishing;response;Rickettsia;Rickettsia conorii;Rickettsia Infections;Rickettsia parkeri;Rickettsia prowazekii;Rickettsia rickettsii;Rickettsial Vaccines;Rocky Mountain Spotted Fever;Role;Safety;Serology;Serotyping;spotted fever;structural determinants;Subunit Vaccines;Technology;Testing;tick bite;tick transmission;tick-borne;Tick-Borne Diseases;tick-borne pathogen;Ticks;treatment choice;Tularemia;Typhus;United States;vaccine development;vaccine efficacy;Vaccines;Variant;vector;Virulence;Work;Yolk Sac

PROJECT_TITLE: Molecular basis of immunity to tick-borne rickettsioses


NIH_SPENDING_CATS: Autoimmune Disease;Lung;Pulmonary Fibrosis;Rare Diseases;Scleroderma

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Systemic Sclerosis (SSc) is a chronic disease that causes impairment of gas exchange in the lungs, leading to respiratory failure. The aims and techniques described in this proposal are expected to answer the fundamental questions that will enhance the understanding of a potential mechanism that mediates lung fibrosis in SSc. Our findings will reveal new pathways by which BHLHB2 signaling perpetuates lung fibrosis and may lead to therapeutic strategies to block the progression of lung fibrosis in SSc.

PI_NAMEs: ADEWALE, ADEGBOYEGA TIMOTHY (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Address;Autocrine Communication;Autophagocytosis;BHLH Protein;Bleomycin;career;cell type;Cells;Chemicals;Chronic Disease;Circadian Rhythms;Collagen;Complication;coronary fibrosis;Data;Deposition;Development;differential expression;Disease;Enzyme-Linked Immunosorbent Assay;Epithelium;experimental study;Extracellular Matrix;Extracellular Matrix Protein Gene;Family;Family member;Feedback;Fibroblasts;Fibronectins;Fibrosis;Foundations;Gases;Genes;Genetic;Genetic Transcription;Goals;Impairment;In Vitro;in vivo;Inflammatory;Inflammatory Response;Insulin Receptor;insulin secretion;Insulin-Like Growth Factor II;Interleukin 6 Receptor;Interleukin-6;Intervention;Knowledge;Link;lipid biosynthesis;Lung;lung development;Lung Diseases;lung injury;Measures;Mediating;Mediator;member;Mentors;Mentorship;Mesenchymal;Microarray Analysis;Mission;Mus;National Heart, Lung, and Blood Institute;novel;Nuclear;Pathogenesis;Pathway interactions;pharmacologic;Physicians;profibrotic cytokine;Proteins;Pulmonary Fibrosis;Pulmonology;Research;Respiratory Failure;response;response biomarker;Rheumatism;RNA;Role;Scientist;Scleroderma;Signal Transduction;single-cell RNA sequencing;Somatomedins;Structure of parenchyma of lung;System;systemic intervention;Systemic Scleroderma;Techniques;Testing;Therapeutic;Training;transcriptomics;Transforming Growth Factor Beta 2;Up-Regulation;Work

PROJECT_TITLE: The role of BHLHB2 in Scleroderma-Associated Lung Fibrosis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Prevention

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Little is known about the spatial features of an orchestrated host defense against a pathogen in situ. How does our immune system coordinate itself against viral infections, and why does it respond differently to diverse virus variants or from the same lineage? This work seeks to combine novel experimental technologies, robust models of disease and clinical samples to elucidate features and mechanisms for host-pathogen interactions, thus providing crucial insights into preventing death and diseases from infectious agents.

PI_NAMEs: JIANG, SIZUN  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;Address;Affect;Animal Model;Antibodies;Autopsy;Bar Codes;Biological;Biological Models;biological systems;Cancer Biology;Cells;Cessation of life;Clinical;combinatorial;Communicable Diseases;Computing Methodologies;Coronavirus;Coupled;COVID-19;COVID-19 pandemic;Data Analyses;data integration;design;Developmental Biology;Disease;disease model;Dissection;Engineering;Epitopes;Eukaryota;Host Defense;Human;imaging platform;Immune;Immune response;Immune system;In Situ;in situ imaging;in vivo;Individual;Infection;Infectious Agent;innovation;insight;Integration Host Factors;invention;Investigation;K-18 conjugate;Methodology;Minor;Modeling;Molecular Virology;mouse model;Mus;Mutation;neutralizing antibody;new technology;next generation;nonhuman primate;novel;Nucleic Acids;pathogen;Pathogenesis;pathogenic virus;prevent;protein aminoacid sequence;Proteins;Research Proposals;response;reverse genetics;RNA Viruses;Rodent;Sampling;SARS-CoV-2 variant;Severe Acute Respiratory Syndrome;System;Technology;technology platform;theories;Therapeutic;Tissue imaging;tissue tropism;Tissues;Tropism;vaccine efficacy;Vaccines;Variant;variants of concern;Viral;Viral Pathogenesis;Virus;Virus Diseases;Work

PROJECT_TITLE: Spatial-Temporal Dissection of Stratified Host Tissue Responses to Severe acute respiratory syndrome-related coronaviruses in situ to Understand Intra-host Pathogenesis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: Influenza A virus (IAV) remains a significant public health concern despite widespread vaccination efforts. Certain individuals are highly susceptible to infection and suffer from serious disease requiring hospitalization. Serious influenza is often associated with the development of an acute respiratory distress syndrome (ARDS) characterized by an uncontrolled inflammatory `cytokine storm' and severely compromised lung function that can be fatal. Current treatments for severe IAV and ARDS are limited to the use of high doses of antivirals, such as Oseltamivir phosphate (tradename Tamiflu) that is most effective when given early during infection, and invasive ventilation, which can double the risk of death. Innovative clinical interventions able to prevent severe respiratory virus infection are urgently needed, especially approaches that can be initiated at later stages of infection. Herein, using a preclinical murine IAV infection model, we will determine key mechanistic underpinnings of a novel application of an interleukin-2-(IL-2) based therapeutic approach that directly (i) promotes pathways to temper inflammation and improve tissue integrity while (ii) concomitantly, also, enhances anti-viral immunity. This proposal is based on our recent observations that directing IL-2 towards the high affinity CD25 subunit of the IL-2 receptor during IAV infection significantly reduces lung immunopathology and improves infection outcomes even when treatment is initiated on day 4 post infection. In addition to promoting expansion of Foxp3+ CD4+ regulatory T cells (T regs), as has often been reported in studies of CD25-targeted IL-2 treatment, we find that innate lymphoid cells (ILC) involved in tissue repair and activated anti-viral T cells, which both also express CD25, are mobilized with treatment. Our findings support that CD25-targeted IL-2 can simultaneously shape both anti- and pro-inflammatory responses during respiratory viral infection. Finally, we also find improved establishment of memory CD4 T cells following infection and treatment, indicating an adjuvant-like quality of this therapeutic approach. The first aim of this proposal will explore how to best utilize this intervention to improve the outcomes of severe IAV infection, in part, by revealing mechanistic insights into how deleterious inflammatory responses arise during serious IAV infection. Our second aim will delineate the role of T regs, ILC, and activated, anti-viral immune cells, in the regulation of IAV infection induced immunopathology and inflammation following CD25-targeted IL-2 treatment. Lastly, the third aim will investigate in depth the persistence and protective functions of IAV-specific immune memory induced in the presence of CD25-targeted IL-2 by IAV infection and vaccination. The insights gained from these studies will advance the development of this IL-2-based therapeutic approach as a treatment for severe respiratory viral infection, as well facilitate its potential use as an adjuvant to boost universal, IAV-specific immunity following vaccination.

PI_NAMEs: STRUTT, TARA MARLENE (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Adjuvant;Advanced Development;Affinity;Animals;Anti-viral Agents;Antibody Formation;antiviral immunity;B-Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Clinical;Combined Modality Therapy;cytokine release syndrome;Development;Disease;Dose;effector T cell;FOXP3 gene;Generations;global health;Goals;Hospitalization;IL2RA gene;Immune;Immunity;Immunoglobulin Class Switching;Immunologic Memory;immunopathology;improved;improved outcome;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza;Influenza A virus;influenza infection;innovation;inorganic phosphate;insight;Interleukin 2 Receptor;Interleukin-2;Intervention;Knowledge;Lung;Lymphocyte;Lymphoid Cell;Memory;memory CD4 T lymphocyte;Modeling;mortality risk;Mus;Names;Natural Killer Cells;novel;Oseltamivir;Outcome;Pathway interactions;Plasma Cells;Population;pre-clinical;Predisposition;prevent;Public Health;pulmonary function;Regulation;Regulatory T-Lymphocyte;Reporting;respiratory infection virus;response;Role;Shapes;Signal Transduction;Structure of germinal center of lymph node;T-Lymphocyte;Therapeutic;Therapeutic Intervention;tissue repair;Tissues;Treatment outcome;Vaccination;ventilation;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases

PROJECT_TITLE: Harnessing targeted IL-2 to reduce immunopathology and enhance immunity against respiratory virus infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Cancer;Nutrition;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Altered metabolism represents a fundamental difference between cancer cells and normal cells that is not well understood. This project uses cell culture models and mouse models of cancer, together with state-of-the-art technology to interrogate metabolic pathway biochemistry to understand what products of metabolism are limiting for cancer cell proliferation, and how they vary in different physiological contexts. This work will inform how to target metabolism for cancer therapy.

PI_NAMEs: VANDER HEIDEN, MATTHEW G. (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Affect;Biochemical;Biochemistry;Biomass;cancer cell;cancer genetics;Cancer Model;Cancer Patient;cancer therapy;cancer type;Cell Culture Techniques;Cell Proliferation;Cells;Cellular Metabolic Process;Diet;Drug resistance;Drug usage;Environment;Environmental Risk Factor;Event;extracellular;Generations;Genetic;genetic approach;glucose metabolism;Goals;insight;interest;Intrinsic factor;Laboratories;macromolecule;Malignant Neoplasms;Mass Spectrum Analysis;Metabolic;metabolic abnormality assessment;Metabolic Pathway;metabolic phenotype;Metabolism;Modeling;mouse model;neoplastic cell;Normal Cell;novel;Nucleotides;Nutrient;Nutrient availability;Patients;Physiological;Physiology;Production;programs;Proliferating;Regulation;Research;Role;Running;Signal Transduction;Supporting Cell;Technology;Testing;Tissues;tool;Trace Elements Nutrition;tumor;tumor growth;tumor initiation;tumor metabolism;tumor microenvironment;tumor progression;Work

PROJECT_TITLE: Understanding the role of metabolism in cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Although early stage colorectal cancer (CRC) is curable (with surgery and adjuvant therapy) metastatic colon cancer is usually lethal. Therefore, our proposal focuses on understanding the regulatory mechanism of a lncRNA our lab discovered to promote oncogenic phenotypes and treatment resistance through its interactions with protein-coding genes. Further, we will address the current lack of reliable biomarkers to assess clinical outcome by investigating whether this lncRNA can be used to determine which localized CRC tumors are likely to progress and metastasize.

PI_NAMEs: MAHER, CHRISTOPHER A (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Address;Adjuvant Therapy;Biological Markers;cancer therapy;Cells;Cessation of life;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;chromatin immunoprecipitation;Clinical;clinical outcome assessment;Code;cohort;colon cancer patients;Colorectal Cancer;colorectal cancer metastasis;colorectal cancer progression;CRISPR/Cas technology;Cytotoxic Chemotherapy;Data;differential expression;Disease;Disease-Free Survival;Distant;DNA topoisomerase II alpha;Drug Screening;Epigenetic Process;epigenetic regulation;experimental study;Exposure to;FDA approved;Fluorouracil;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;high risk;In Vitro;in vivo;insight;Knock-out;Large-Scale Sequencing;Length;Longterm Follow-up;Meta-Analysis;metastatic colorectal;Metastatic/Recurrent;Methods;Modality;Modeling;Molecular;molecular phenotype;Monitor;Mutate;Neoplasm Metastasis;Nuclear;Oncogenic;Operative Surgical Procedures;Organoids;patient derived xenograft model;Patients;Phenotype;Primary Neoplasm;Prognosis;Prognostic Marker;prospective;Protein Isoforms;Proteins;recruit;Regimen;Regulation;Repression;Research;Resistance;response;Risk;RNA;Role;Sampling;side effect;Site;Staging;Stratification;Testing;The Cancer Genome Atlas;Therapeutic;therapy resistant;Tissues;Topoisomerase Inhibitors;Transcript;transcriptome sequencing;translational impact;tumor;Tumor Biology;tumorigenesis;Validation

PROJECT_TITLE: The role of RAMS11 in colorectal cancer progression and treatment resistance

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pneumonia and Influenza;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE There is an urgent need to understand the impact of SARS-CoV-2 on the pregnant women, her fetus and offspring, particularly in resource-limited settings where the influenza and other respiratory viruses continue to circulate. The ICOPE (Influenza & COVID Obstetric and Perinatal Epidemiology) Study in India, leverages recent experience in studying Influenza in women recruited early in pregnancy to rapidly address these important questions and potentially inform public health approaches.

PI_NAMEs: HIBBERD, PATRICIA L (contact);PATEL, ARCHANA

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: 2019-nCoV;Acute-Phase Proteins;Address;Admission activity;antenatal care;Antibodies;asymptomatic COVID-19;at-risk pregnancies;biobank;Biological Markers;Birth;Birth Weight;Blood;breakthrough infection;Centers for Disease Control and Prevention (U.S.);Child;China;cohort;Cohort Studies;Collaborations;Collection;Communicable Diseases;Country;COVID-19;COVID-19 impact;COVID-19 patient;COVID-19 risk;COVID-19 severity;COVID-19 vaccination;COVID-19 vaccine;Critical Illness;cytokine;Data;Discipline of obstetrics;Disease;Dryness;Emergency Situation;Enrollment;epidemiology study;experience;fetal;Fetus;First Pregnancy Trimester;follow-up;Funding;Future;Hospitalization;Hospitals;Immune response;Immunoglobulin G;Immunoglobulin M;Incidence;Income;India;Infection;Inflammatory;Influenza;influenza infection;Intensive Care;Investigation;Joints;Laboratories;Late pregnancy;Life;low and middle-income countries;Maternal Mortality;maternal outcome;maternal risk;Mediating;Mediator;mortality;Mothers;nasopharyngeal swab;National Institute of Child Health and Human Development;Neonatal;neonate;Newborn Infant;Observational Study;offspring;Outcome;Pattern;Perinatal Epidemiology;Perinatal mortality demographics;perinatal outcomes;Polymerase Chain Reaction;Positioning Attribute;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy loss;Pregnant Women;Premature Birth;Premature Labor;Prevalence;Prevention;primary outcome;Province;Public Health;Publications;Readiness;recruit;Reporting;Resource-limited setting;respiratory infection virus;Respiratory Signs and Symptoms;respiratory virus;Reverse Transcription;Risk;Risk Factors;SARS-CoV-2 antibody;SARS-CoV-2 infection;seasonal influenza;secondary analysis;Severities;Site;Specimen;Spottings;stillbirth;symptomatic COVID-19;Symptoms;Tablets;Testing;Time;ultrasound;Update;Vaccination;Vaccines;variants of concern;Visit;Woman

PROJECT_TITLE: Influenza & COVID Obstetric and Perinatal Epidemiology Study in India

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-E(02)]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Bacteria thrive in a myriad of niches, including our own bodies, where they fight for survival under ever changing adverse conditions. We develop novel tools and use them to understand how these tiny organisms adapt and grow in every corner of the planet.

PI_NAMEs: GROSS, CAROL ANNE (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Acceleration;Address;Affect;Area;Bacteria;Bacterial Genome;Base Pairing;cell envelope;Coupled;Coupling;CRISPR interference;Data;Databases;empowerment;Environment;environmental change;Essential Genes;Evolution;fighting;fitness;gene function;gene regulatory network;Genes;genetic analysis;Genetic Transcription;genome-wide;Goals;Grant;Growth;Homeostasis;knock-down;Measurement;Measures;Metagenomics;model organism;mRNA Transcript Degradation;Mutation;new technology;novel;Organism;Output;Pathway interactions;Phylogenetic Analysis;Planets;prevent;Process;Proliferating;Property;Recording of previous events;Research;Research Personnel;research vision;Ribosomal Proteins;Ribosomes;Stress;success;synergism;Technology;Titrations;tool;Transcription Process;Translations

PROJECT_TITLE: Cellular homeostasis pathways in bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Genetics;Hematology

PHR: PROJECT NARRATIVE Post-transcriptional regulation has become increasingly important in determining the amount of functional protein produced in a cell. Thus, altering the levels of mRNA transcripts can have major physiological consequences to human health, contributing to cancer as well as haploinsufficiency disease. Codon optimality- mediated mRNA decay is the fundamental mechanism that ties translation rate to mRNA stability. While we know that the open reading frame of a transcript determines its overall stability, it is not known how mRNAs are differentially regulated by the decay machinery. Therefore, investigating the mechanism of codon optimality- mediated decay is imperative to understanding how transcript half-lives are determined and will open avenues for therapeutic intervention into haploinsufficiency as well as cancer.

PI_NAMEs: CHRISTENSEN, LANA NICOLE (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Acute T Cell Leukemia;Address;Adult Precursor T Lymphoblastic Leukemia;Affect;Binding;Biological Models;Bone Marrow;Cells;Codon Nucleotides;Communication;Complex;Couples;Cryoelectron Microscopy;Data;Defect;Disease;dosage;Eukaryota;Event;Excision;Exhibits;Genetic Transcription;Health;Homologous Gene;Human;human disease;insight;Knowledge;Link;Malignant Neoplasms;Mediating;member;messenger ribonucleoprotein;Messenger RNA;Molecular;Monitor;mRNA capping;mRNA decapping;mRNA Decay;mRNA Stability;mRNA Transcript Degradation;mutant;Mutate;N-terminal;nanopore;Northern Blotting;Open Reading Frames;Pathway interactions;Phenotype;Physiological;Poly(A) Tail;polysome profiling;Post-Transcriptional Regulation;Process;Production;Proteins;Radiolabeled;recruit;Reporter;Ribosomal Interaction;Ribosomes;RNA Decay;Role;Saccharomyces cerevisiae;Saccharomycetales;Scaffolding Protein;Series;Site;Structure;Tail;Testing;Therapeutic Intervention;Time;Transcript;Translating;Translations;Tumor Suppressor Proteins;Western Blotting;Work;Yeasts

PROJECT_TITLE: Investigating the role of the Ccr4-Not complex in regulating codon optimality-mediated mRNA decay

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ORG_DEPT: OPHTHALMOLOGY

PHR: UAB Center for Vision Research - Overall Core Project Narrative Twenty-five investigators with significant overall support from the National Institutes of Health rely on the support of the NEI P30 UAB Core Grant for Vision Research to supplement resources to raise their level of scientific inquiry and discovery, and to avoid unnecessary duplication of shared resources. These investigators are studying various ocular disorders such as glaucoma, age related macular degeneration, retinitis pigmentosa, dry eye and other disorders that collectively affect the quality of life of millions of Americans. Core research supports novel studies that are designed to improve diagnostics and treatment for these devastating disorders.

PI_NAMEs: GAMLIN, PAUL DOUGLAS (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Affect;Age related macular degeneration;American;analytical tool;Anatomy;Animal Model;Area;Award;Benchmarking;Big Data;Biochemical;Biometry;Caliber;career;Cataract;Cells;Collaborations;Complement;Computer Analysis;computer program;Computer software;Computers and Advanced Instrumentation;Consensus;Core Facility;Core Grant;Custom;Data Analyses;Database Management Systems;Databases;design;Development;Diagnostic;Disease;DNA;Doctor of Philosophy;Elements;Ensure;Equipment;Expenditure;experimental analysis;Experimental Designs;Extramural Activities;Eye diseases;eye dryness;Faculty;First Independent Research Support and Transition Awards;Funding;Glaucoma;Goals;Grant;Growth;Hour;human model;Image;Image Analysis;improved;Individual;innovation;Institution;instrument;instrumentation;K-Series Research Career Programs;Keratoconus;Maintenance;mechanical device;meetings;Modality;Molecular;Monitor;Morphology;Myopia;Names;novel;Outcome;Participant;Phenotype;Physiological;Productivity;programs;Proteins;Psychophysics;Publications;Quality of life;recruit;repaired;Request for Applications;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Retina;Retinitis Pigmentosa;RNA;satisfaction;Scientific Inquiry;Scientist;Services;skills;Structure;success;Surveys;synergism;Technology;Time;Tissues;Training;United States National Institutes of Health;Vision;Vision Disorders;Vision research;vision science;visual neuroscience;Visual Pathways

PROJECT_TITLE: UAB Core Grant for Vision Research


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: SAMUELS, BRIAN CHRISTOPHER (contact)

PROJECT_TERMS: Advisory Committees;Applications Grants;Area;Awareness;Budgets;Businesses;Center Core Grants;Collaborations;Core Grant;cost;design;Discipline;editorial;educational atmosphere;Electronic Mail;Ensure;experience;Eye diseases;Faculty;Feedback;Fostering;Funding;Funding Opportunities;graduate student;Grant;Individual;Institution;Laboratory Personnel;Manuscripts;Measures;meetings;member;Mission;Monitor;National Eye Institute;operation;Ophthalmology;Optometry;Outcome;Output;Participant;Personnel Staffing;Policies;posters;Preparation;Productivity;programs;Publications;Qualifying;Recording of previous events;recruit;repaired;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;Role;Running;satisfaction;Science;Scientist;Series;Services;Strategic Planning;Study Section;Surveys;Training;United States National Institutes of Health;Universities;Update;Vision;Vision research;vision science;web site

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: ROME

ORG_COUNTRY: ITALY

ORG_FIPS: IT

ORG_NAME: FOOD & AGRICULTURAL ORG/UNITED NATIONS

PHR: Project Narrative This project aims to strengthen global food safety through the promotion of healthy and safe food via prevention-based food production practices in sustainable land and water management for producers and growers for reduced incidence of foodborne contamination from source, improved protection of supply chain controls and food safety, enhanced economic development and improving livelihoods by facilitating access to domestic, regional and international markets. Water plays a central and connecting role in food production, animal health, public health and the environment and the linkages between agricultural water quality and use and the incidence of foodborne pathogens must be further understood to develop the evidence-based policy guidance necessary for the effective prevention, detection and response to disease outbreaks. Developing preventative measures to pathogens in water through sustainable land and water management for agriculture production, enhancing monitoring systems to consistently included pre-harvest factors that may also affect food safety and utilizing metagenomics science and hydrological modelling to expand collective knowledge of global geographic variation of foodborne pathogens in water used for irrigation are key to shifting the focus of regulators towards preventing, rather than responding to, foodborne contamination at source.

PI_NAMEs: KOO-OSHIMA, SASHA  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, KEVIN

PROJECT_TITLE: Water quality, irrigation and on-farm controls for achieving global food safety and nutritional security


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SINCICH, LAWRENCE C (contact)

PROJECT_TERMS: 3-Dimensional;3D Print;Alloys;Area;Associate Degree;Benchmarking;biomaterial compatibility;Center Core Grants;Computer Assisted;Computer-Aided Design;Computers;Core Grant;Custom;data acquisition;design;Device Designs;Devices;digital;digital platform;Equipment;experience;experimental study;Funding;Goals;graduate student;Grant;Hour;improved;Individual;instrument;Laboratories;Learning;Macaca;manufacture;manufacturing process;mechanical device;Mechanics;Modernization;Modification;Monitor;novel;Outcome;Participant;Plastics;Postdoctoral Fellow;Process;Production;Productivity;Publications;Recommendation;repaired;Research;Research Personnel;satisfaction;Schedule;Science;Services;success;Surveys;Time;Tupaiidae;Vision research;vision science;Visualization;Work

PROJECT_TITLE: Machine Shop Core


ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE – Overall. People with Down syndrome are strongly predisposed to develop a wide range of comorbidities that shorten their lifespan and decrease their quality of life, such as Alzheimer’s disease, congenital heart disease, leukemias, autoimmune disorders, and diverse neurological conditions. The proposed activities under this project seek to create a world-class resource for collaborative discovery, data sharing, data access, and integrative analysis that would enable novel investigations into all DS comorbidities across the lifespan and further integrating across datasets for related diseases occurring in the general population, thus paving the way for a precision medicine approach to DS. Furthermore, this resource and associated platforms will also have broader impacts by empowering physicians, educators, government officials, and advocates with the tools required to elicit evidence- based transformative action in the clinic, the classroom, the government, and society at large.

PI_NAMEs: CARROLL, ROBERT J;DIGIOVANNA, JACK ;ESPINOSA, JOAQUIN M.;FERRETTI, VINCENT ;HAENDEL, MELISSA A;RESNICK, ADAM CAIN (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Acceleration;Advocacy;Advocate;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid Beta A4 Precursor Protein;Area;autism spectrum disorder;Autoimmune Diseases;Automobile Driving;bench to bedside;biobank;Biomedical Research;Child;Chromosome 21;Chromosomes;Clinic;Clinical;Cohort Studies;Collaborations;Communities;community empowerment;comorbidity;Complex;congenital heart abnormality;Data;data access;Data Coordinating Center;data ecosystem;data integration;data management;data modalities;data portal;data resource;Data Set;data sharing;data sharing networks;design;Development;Discipline;Disease;diverse data;Down's Syndrome;Ecosystem;Education;empowerment;Ensure;Environmental Risk Factor;epidemiology study;Epigenetic Process;Epilepsy;evidence base;Family;General Population;Genetic Diseases;Genetic Variation;Goals;Government;Government Officials;Human;Human Biology;Individual;innovation;interoperability;Intuition;Investigation;leukemia;Life Cycle Stages;Life Expectancy;life span;lifestyle factors;Link;Malignant Neoplasms;metabolome;Methods;microbiome;Mission;Multiomic Data;Neurologic;novel;novel diagnostics;novel therapeutics;outreach;Participant;Pathogenicity;Persons;Phenotype;Physicians;Population;precision medicine;prenatal;Proteome;Quality of life;Research;Resources;Risk;Schools;Scientist;Societies;Solid;Surveys;synergism;Technology;Time;timeline;tool;Training;transcriptome;United States National Institutes of Health;Variant;virtual

PROJECT_TITLE: Data Management and Portal for the INCLUDE (DAPI) Project


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Pediatric

PI_NAMEs: ESPINOSA, JOAQUIN M. (contact)

PROJECT_TERMS: Acceleration;Advisory Committees;Advocacy;advocacy organizations;Advocate;Affect;Archives;Automobile Driving;Clinic;clinical practice;Collaborations;Colorado;Communication;Communities;community engagement;comorbidity;Data;data access;Data Analyses;Data Coordinating Center;data ecosystem;data management;data portal;data sharing;design;Development;Down's Syndrome;Education;Educational workshop;empowerment;Ensure;Event;evidence base;Feedback;General Population;Goals;Government;Government Officials;Human Resources;Investigation;Laboratories;Leadership;meetings;Mission;Modeling;online tutorial;operation;outreach;Pediatric Hospitals;performance site;Persons;Philadelphia;Physicians;Policies;Population;Procedures;Progress Reports;recruit;Registries;Research Personnel;Resources;Scientist;Site;Societies;Source;success;System;tool;Training;United States National Institutes of Health;Universities;usability

PROJECT_TITLE: Administrative and Outreach Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IFCN-U]


PI_NAMEs: PITTLER, STEVEN J (contact)

PROJECT_TERMS: Animal Model;Area;base;Basic Science;Benchmarking;Biochemistry;Cellular biology;Collaborations;Computer software;Core Facility;Core Grant;cryostat;Dedications;Disease;Doctor of Philosophy;Education;Ensure;Equipment;experience;Fluorescence;fluorescence microscope;Freezing;Funding;Histology;Hour;Human Resources;improved;Institution;Island;Kinetics;Knowledge;Laboratories;Lead;light microscopy;Microscope;Microscopic;microscopic imaging;Molecular;Molecular Biology;Monitor;Neurobiology;Newsletter;Nucleic Acids;Outcome;Paper;Paraffin;Participant;Preparation;Productivity;Proteins;Publications;Publishing;Reader;Research Personnel;response;Retinal Degeneration;satisfaction;Schedule;Scientist;skills;Source;square foot;Students;success;Surveys;System;Technology;Time;Tissue Embedding;tissue processing;Training;Translational Research;United States National Institutes of Health;Update;Vision;Vision research;vision science;Visualization

PROJECT_TITLE: Molecular & Cellular Analysis Core


ADMINISTERING_IC: DC

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Pediatric

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative Speech and other forms of learned vocal communication depend critically on hearing. We must better understand how central auditory processes facilitate and constrain vocal learning and the perception and production of vocal communication behavior. This fundamental knowledge will aid recognition and treatment of speech communication deficits observed in autism spectrum disorder, developmental delay, presbycusis, otitis media and others.

PI_NAMEs: WOOLLEY, SARAH M (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Acute;Adult;Animal Model;Auditory;Auditory area;Auditory Perception;auditory processing;autism spectrum disorder;Back;Behavior;Behavioral;Biological Assay;Birds;Brain;Child;Chronic;Code;Communication;communication behavior;comparative;Data Analyses;design;Development;Developmental Delay Disorders;Diagnosis;Disease;early experience;Electrophysiology (science);experience;experimental study;flexibility;Frequencies;Genetic;genetic architecture;Goals;Grant;Hearing;Human;improved;Infant;insight;instrument;Knowledge;Language;Language Development;learned behavior;Learning;Life;Measures;Mission;Modeling;neural;neuromechanism;Neurons;neurophysiology;novel;Operant Conditioning;Otitis Media;Pathway interactions;Pattern;Perception;Phonetics;preference;Presbycusis;Prevention;Process;Production;Property;Research;Resolution;response;Shapes;skills;Songbirds;sound;Speech;Speech Perception;Speech Sound;Structure;syntax;Testing;Time;Training;tutoring;United States National Institutes of Health;vocal learning;vocalization;Voice;Work;zebra finch

PROJECT_TITLE: Neural coding and perception of learned vocalizations

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Brain Disorders;Data Science;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Networking and Information Technology R&D (NITRD)

PI_NAMEs: GUINNEY, JUSTIN  (contact)

PROJECT_TERMS: Acceleration;Accent;Address;Area;Automobile Driving;biobank;Bioinformatics;Biomedical Research;Clinical;Clinical Data;cloud based;cohort;Collaborations;Collection;Communities;community building;comorbidity;Complex;computerized data processing;Consensus;dashboard;Data;Data Analyses;Data Collection;Data Coordinating Center;Data Discovery;data ecosystem;data exchange;data harmonization;data ingestion;data management;Data Management Resources;data modeling;Data Pooling;data portal;data quality;data sharing;data sharing networks;data standards;Development;Disease;Disparity;diverse data;Down's Syndrome;Elements;Ensure;Environment;experience;FAIR principles;Funding;Goals;human disease;Human Resources;Image;improved outcome;Individual;Ingestion;innovation;insight;interoperability;Investigation;Leadership;life span;Maps;member;Metadata;Mission;Molecular;Multiomic Data;multiple data types;novel;outreach;Pathway interactions;Persons;Phenotype;Play;Population;Positioning Attribute;Process;Publishing;Qualifying;Quality Control;Reporting;repository;Research;Research Project Grants;Resources;Role;Secure;Site;Source;Standardization;Stress Tests;Structure;Technology;trait;United States National Institutes of Health;usability;Validation;virtual;Vision;Work;working group

PROJECT_TITLE: Data Management Core


NIH_SPENDING_CATS: Brain Disorders;Data Science;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Networking and Information Technology R&D (NITRD);Pediatric

PI_NAMEs: RESNICK, ADAM CAIN (contact)

PROJECT_TERMS: Academic Medical Centers;Acceleration;Advocacy;Advocate;analytical tool;Area;Automobile Driving;Big Data;biobank;Biological;Biological Specimen Banks;Biomedical Research;Child;Clinical;Clinical Data;Clinical Informatics;cloud based;cohort;Collaborations;Colorado;Communities;comorbidity;computational platform;Computer software;Data;data access;Data Analyses;Data Coordinating Center;Data Element;data integration;data management;data portal;data resource;Data Scientist;Data Set;data visualization;Databases;Development;Down's Syndrome;Ecosystem;Education;empowerment;Ensure;Environment;Etiology;experience;experimental analysis;Family;Feedback;genomic data;Genomics;Goals;Human;Individual;Infrastructure;innovation;Internet;interoperability;Intuition;Libraries;Life Style;Link;member;metabolome;Methodology;Mission;Mothers;Multiomic Data;new technology;Online Systems;outreach;Participant;Pathway interactions;Pediatric Hospitals;Performance;Philadelphia;Population;portability;Prevalence;Proteome;Recommendation;repository;Research;Research Methodology;Research Personnel;Resources;search engine;Series;Software Engineering;Specimen;Structure;success;Technology;tool;Training;transcriptome;United States National Institutes of Health;Universities;University Hospitals;Variant;Visualization;Visualization software;web interface;Work;working group

PROJECT_TITLE: Data Portal Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: KRAFT, TIMOTHY W (contact)

PROJECT_TERMS: adaptive optics scanning laser ophthalmoscopy;Anatomy;Angiography;Animal Model;animal resource;animal tissue;Animals;Anterior;Area;Award;Basic Science;behavior test;Benchmarking;Biological Assay;body position;Body System;Cells;Clinical;Collaborations;Color;Communities;Contrast Sensitivity;Core Facility;Core Grant;Cornea;Custom;Dedications;design;digital;Disease;Dyes;Electroretinography;Engineering;Environment;Equipment;Expenditure;experience;Experimental Designs;Eye;fluorescence imaging;Funding;fundus imaging;Fundus photography;Growth;Health;Heart;Human;Human Resources;human subject;Image;imaging system;improved;in vivo;Individual;instrument;instrumentation;interest;Iris;Laboratories;lens;Microscope;Monitor;mouse model;multimodality;Mus;novel diagnostics;Ocular Physiology;operation;Operative Surgical Procedures;Optic Disk;Optical Coherence Tomography;Optokinetic nystagmus;Outcome;Outcome Measure;Participant;Phenotype;Physiological;Postdoctoral Fellow;power analysis;Productivity;Publications;Rattus;research facility;Research Personnel;Research Support;response;Retina;retinal imaging;Rodent;S10 grant;satisfaction;Scientist;Signal Transduction;slit lamp imaging;Source;Standardization;statistics;Structure;Students;success;Surveys;System;Technology;Testing;Time;Tissues;tool;Training;Translational Research;Tupaiidae;Validation;Vision;Vision research;vision science;Visual;Visual Acuity;visual motor;Visualization;Zebrafish

PROJECT_TITLE: Ocular Phenotyping Core


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative The heart beats over 2 billion times during a human life to pump blood around the body, however this essential function can be cut short by dyssynchronous heart failure. Cardiac Resynchronization Therapy (CRT) has emerged as a potentially effective therapy to reverse this deadly disease and can be personalized for each patient, yet there are far too many options for a doctor to test during surgery. Therefore, the goal of this project is to develop a computer model to predict and improve the outcome of personalized CRT, thus potentially improving the success rate of CRT and treating heart failure in more patients.

PI_NAMEs: BILCHICK, KENNETH C (contact);HOLMES, JEFFREY W

PROGRAM_OFFICER_NAME: HSU, LI-YUEH

PROJECT_TERMS: Acute;Adrenergic beta-Antagonists;American;Anatomy;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Blood Pressure;blood pump;Blood Tests;Body Surface Potential Mapping;Brain natriuretic peptide;Bundle-Branch Block;Canis familiaris;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;cardiac resynchronization therapy;Cells;Cicatrix;Circulation;Clinical;Clinical Data;Complex;Computer Models;Data;Death Rate;design;Devices;Disease;effective therapy;Electric Stimulation;Electrocardiogram;Electrophysiology (science);Elements;experience;Goals;Growth;Heart;Heart failure;Heart Hypertrophy;Hormonal;hormonal signals;Human;imaging study;implantation;improved;improved outcome;individual patient;individualized medicine;Infarction;innovation;Ischemia;Lead;Left;Left ventricular structure;Life;Location;Magnetic Resonance Imaging;Measurement;mechanical signal;Mechanics;Methods;Modeling;multi-scale modeling;Myocardial Contraction;Myocardial dysfunction;Myocardial Infarction;Myocardium;network models;Operative Surgical Procedures;Outcome;Patients;Pharmaceutical Preparations;Physiology;predictive modeling;Procedures;Protocols documentation;Publishing;Regimen;Research Personnel;response;routine care;Signal Pathway;Signal Transduction;simulation;standard of care;success;Symptoms;Testing;therapy outcome;Time;treatment planning;Ventricular;Ventricular Remodeling;virtual therapy

PROJECT_TITLE: Multiscale Models for Predicting Short and Long-term Outcome of Cardiac Resynchronization Therapy

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

PI_NAMEs: DOWNS, J CRAWFORD (contact)

PROJECT_TERMS: 4D Imaging;adaptive optics;Address;Advanced Development;algorithm development;Area;Basic Science;Benchmarking;Cells;Clinical;Clinical Research;Collaborations;Communities;Computer Analysis;Computer Interface;Computer software;Computers;computing resources;Core Facility;Core Grant;cost;Custom;Data;data acquisition;Data Analyses;data management;data quality;data repository;database design;Databases;design;Development;Device Designs;Device or Instrument Development;Devices;digital;digital data;Ensure;Equipment;experience;Faculty;flexibility;Funding;Goals;Grant;High Performance Computing;Hour;Human Resources;Image;Image Analysis;image processing;imaging modality;improved;In Vitro;Individual;innovation;instrument;instrumentation;Intuition;Laboratories;Microscopy;Monitor;Optical Coherence Tomography;Outcome;Participant;Patients;Process;programs;Publications;Qualifying;Reproducibility;Research;research faculty;Research Personnel;research study;response;Running;satisfaction;Scheme;Scientist;Services;skills;Speed;success;Surveys;Techniques;Three-Dimensional Image;Time;tool;Training;United States National Institutes of Health;Vision;Vision research;Work

PROJECT_TITLE: Research Programming & Computational Analysis Core


NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Chronic Pain;Clinical Research;Neurosciences;Pain Research;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rehabilitation

ORG_CITY: ST. PAUL

ORG_NAME: GILLETTE CHILDREN'S SPECIALTY HEALTHCARE

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because chronic pain, including chronic postoperative pain (CPSP; pain that develops or worsens after surgery) places significant burden on the healthcare system and can impact all aspects of life, extend opioid use, and diminish surgical outcomes. Surgery is common in children with cerebral palsy (CP) and pain-specific outcomes have rarely been documented; there remains a need to thoroughly measure pain before and after surgery, associated surgical outcomes, and to identify factors that may predict CPSP and persistent opioid use. This work will support future efforts to reduce the incidence and severity of CPSP in CP and is relevant to the part of NIH’s mission dedicated to better understanding the experience of pain, the challenge of treatment, and the transition from acute to chronic pain.

PI_NAMEs: BURKITT, CHANTEL COURTNEY (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Acute;Address;Anxiety;biobehavior;Cerebral Palsy;Characteristics;Child;Chronic;chronic pain;Clinical;Complex;Decision Making;Dedications;Development;disability;Distress;Exclusion;experience;Future;gabapentin;Gait;General Population;Goals;Healthcare Systems;improved;Incidence;indexing;Individual;individual patient;innovation;Intervention;kinematics;Knowledge;knowledge translation;Life;Literature;Location;Measures;meetings;Mission;Nature;Nerve Block;network models;Neuropathy;Operative Surgical Procedures;opioid use;Orthopedic Procedures;Orthopedic Surgery;Orthopedics;Outcome;Pain;pain catastrophizing;pain chronification;Pain management;Pain Measurement;pain reduction;Pain Research;pain sensitivity;Parents;pediatric patients;Perioperative;Persistent pain;Positioning Attribute;Postoperative Pain;Predictive Factor;Prevalence;prophylactic;psychosocial;Psychosocial Factor;Public Health;Quality of life;Reporting;Research;Risk;Risk Factors;Sampling;Sensory;Severities;Site;Source;Spinal Fusion;Subgroup;surgery outcome;Testing;Therapeutic;Therapeutic Intervention;Time;translational potential;United States National Institutes of Health;Work

PROJECT_TITLE: Chronic Postsurgical Pain in Cerebral Palsy

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]