NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Narrative Accumulation of misfolded Tau and neurofibrillary tangles plays a critical role in AD and other neurodegenerative diseases. The goal of the application is to investigate the role of the lysosomal master regulator TFEB in addressing Tau pathology and immune system regulation. It will establish a mechanistic framework and reveal neuronal and glial targets that are critical in the prevention and intervention of AD and other diseases of tauopathy.

PI_NAMEs: ZHENG, HUI  (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease brain;Animals;Astrocytes;Autophagocytosis;Autopsy;Behavioral;Binding;Biochemical;Biological Models;Brain;Cell Nucleus;cell type;Cells;Complex;Cytoplasm;Data;Data Set;Disease;Exocytosis;Exportins;FRAP1 gene;Frontotemporal Dementia;Gene Expression Profile;Genes;Goals;Grant;Hela Cells;Homeostasis;Human;hyperphosphorylated tau;Immune;Immune system;Immunoprecipitation;Impaired cognition;Impairment;In Vitro;inhibitor;insight;Intervention;Knock-in Mouse;Lipids;Lysosomes;Mediating;Microglia;Molecular;Morphology;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;Neurons;novel;Nuclear;Nuclear Export;Nuclear Translocation;oleoylethanolamide;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phosphorylation;Phosphorylation Site;Physiological;Play;Post-Translational Protein Processing;prevent;Prevention;promoter;Property;Proteomics;Proxy;Regulation;Regulatory Pathway;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;small molecule;Sorting;Stress;System;tau aggregation;tau function;tau Proteins;Tauopathies;Testing;Therapeutic Intervention;trafficking;Transcription Coactivator;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transfection;Transgenic Mice;Up-Regulation;vacuolar H+-ATPase

PROJECT_TITLE: ROLE OF TFEB IN TAUOPATHY


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Most neurological disorders, including Obsessive-compulsive disorder and Autism spectrum disorder, include deteriorations in our ability to make adaptive decisions and flexibly adjust our behavior. A richer cellular and circuit-level understanding of how flexible behavior is generated may inform new therapeutic strategies for targeting these conditions, reducing the heavy burden they place on individuals and society.

PI_NAMEs: MAIMON, GABY  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Adaptive Behaviors;Anatomy;Animal Behavior;Animal Model;Animals;Association Learning;autism spectrum disorder;Behavior;Behavioral;Biological Models;Brain;cellular imaging;Cognition;cognitive neuroscience;conditioning;Decision Making;Deterioration;dopaminergic neuron;Drosophila genus;Drosophila melanogaster;egg;Electrophysiology (science);Environment;expectation;experience;experimental study;Face;flexibility;fly;forging;Future;Genetic;Glean;Grant;Hand;Human;Impairment;Individual;Insecta;insight;Laboratories;Learning;Lobe;Mammals;Measures;Methods;millisecond;Modeling;Movement;Mushroom Bodies;Nature;Nervous System Disorder;neural;neural circuit;Neurologic;Neurons;neurophysiology;Neuropil;Neurosciences;neurotransmission;nonhuman primate;novel therapeutic intervention;Obsessive-Compulsive Disorder;Output;Pattern;Physiological;Preparation;Ramp;Reflex action;Response to stimulus physiology;Rewards;Role;sensory input;sensory stimulus;Signal Transduction;Social Interaction;Societies;Structure;System;Testing;Therapeutic;Thinking;Time;Update;Urticaria;visual learning;visual stimulus;Wasps;Work

PROJECT_TITLE: Understanding the Role of Quantitative Internal Signals in Behavioral Flexibility


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: The ability to perform different movements in the appropriate order is essential for purposeful behavior and survival, and defects in the brain regions that underlie movement selection can lead to neurological disorders that exhibit abnormally repetitive movements (e.g. autism spectrum disorder). Yet, how neural circuits assemble sequences of movements is poorly understood. In this project, we use innovative neurogenetic methods to provide a highly detailed circuit-level view of a behavioral sequence to better understand how interactions between neurons produce sequenced movements in animals.

PI_NAMEs: SEEDS, ANDREW MICHAEL (contact)

PROJECT_TERMS: Abdomen;Animals;Architecture;autism spectrum disorder;Behavior;Behavior Disorders;Behavioral;Behavioral Mechanisms;Body part;Brain;Brain Diseases;Brain region;Chest;Complex;Dedications;Defect;Dissection;Drosophila genus;Drosophila melanogaster;Dust;Ensure;Exhibits;Eye;fly;Genetic;genetic approach;Grooming;Human;Infrastructure;innovation;Knowledge;Leg;Link;Maps;Methods;Modeling;motor behavior;Movement;Movement Disorders;Nervous System Disorder;Nervous System Physiology;neural;neural circuit;neurogenetics;neuromechanism;Neurons;Outcome;Output;Performance;Research;Resolution;Rodent Model;Role;Sensory;Synapses;System;Techniques;Testing;Time;tool;Visualization;Wing

PROJECT_TITLE: High-resolution synaptic and functional connectivity mapping of a neural circuit architecture underlying a behavioral sequence


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Nearly every normal behavioral process and disorder of the nervous system is thought to involve the coordinated activity of large groups of neurons. The relationship between neurons and behavior is profoundly nonlinear, so new, nonlinear methods will be required to predict behavior from the activity of neural populations. This ability would revolutionize the way neuropsychiatric disorders are diagnosed and treated because it would be invertible, allowing clinicians to use behavioral methods to diagnose differences in neuronal population activity.

PI_NAMEs: COHEN, MARLENE ROCHELLE;HUANG, CHENGCHENG ;RINALDO, ALESSANDRO ;RUNYAN, CAROLINE ANNE (contact)

PROJECT_TERMS: Affect;algebraic topology;Area;association cortex;Attention;Behavior;behavior prediction;Behavioral;Biology;Biophysics;Bite;Brain;Calibration;cell type;Cognition;Cognitive;cognitive process;cognitive system;Complex;Data;Data Analyses;Decision Making;detector;Diagnosis;Dimensions;Electrophysiology (science);Esthesia;flexibility;Goals;Image;information processing;Information Theory;inhibitory neuron;insight;Interneurons;Link;Macaca mulatta;mathematical theory;Mathematics;Measurement;Measures;Metals;Methods;Modeling;Monkeys;Motivation;Mus;Nervous System Disorder;neural;neural network;neuronal circuitry;Neurons;neurophysiology;neuropsychiatric disorder;novel;novel strategies;Oceans;optogenetics;Parietal Lobe;Perception;Performance;Physiological;Population;predictive modeling;Primates;Process;Psychophysics;Recurrence;response;Rewards;Role;Sensory;Sensory Process;sensory system;Stimulus;Structure;success;System;Testing;Time;tool;two-photon;Visual;Visual Cortex;Work

PROJECT_TITLE: Topological bridges between circuits, models, and behavior


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

ORG_STATE: CA

PHR: Project Narrative This project will study how the brain processes visual information to support navigation, which is important for guiding goal-directed movement through the world. The results of this work will provide knowledge about normal visual function and insights for treating impaired vision via prosthetic or assistive devices.

PI_NAMEs: GOARD, MICHAEL ;NIELL, CRISTOPHER M;SMITH, SPENCER LAVERE (contact)

PROJECT_TERMS: Animals;Area;Behavior;Behavioral;Brain;Code;Complex;Conflict (Psychology);Cues;Data;deep neural network;Detection;Discrimination;Electrophysiology (science);entorhinal cortex;Environment;experimental study;Frequencies;Goals;Head;high dimensionality;Hippocampus;Image;insight;Investigation;Knowledge;Location;Measurement;Measures;Modeling;Motion;Movement;Mus;Nature;neural;Neural Network Simulation;novel;object recognition;optic flow;orientation selectivity;Play;Population;Process;Property;Prosthesis;response;Rotation;Sampling;Self-Help Devices;Sensory;Signal Transduction;Space Models;statistics;Stimulus;Structure;synergism;Testing;theories;two-photon;Update;virtual reality;virtual reality system;virtual world;Vision;Visual;Visual Cortex;Visual impairment;visual information;visual processing;visual stimulus;Visual System;Visuospatial;Work

PROJECT_TITLE: Cortical visual processing for navigation


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases;Sleep Research

ORG_CITY: AMHERST

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Narrative Progressive Supranuclear Palsy (PSP) is a devastating neurodegenerative disease, which shares attributes with Alzheimer's Disease; tau protein aggregates, cognitive and motor deficits. Our goal is to identify neurons that are perturbed early in the disease process and that contribute to key aspects of the behavioral deficits and underlying pathology. This knowledge will allow for improved diagnosis and the initiation of pharmacotherapeutic discovery programs.

PI_NAMEs: CLARK, STEWART DONALDSON (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: 3-Dimensional;Acoustics;Acute;Age;Aging;Alzheimer's Disease;Animals;Area;Attentional deficit;Autopsy;Behavior;behavior test;Behavioral;Benign;Biochemical;Biological;Biological Markers;Brain;Brain region;Characteristics;cholinergic;cholinergic neuron;Clinical;clinically relevant;Cognitive;Cognitive deficits;cohort;Collaborations;Data;Dependovirus;Diagnosis;diagnostic accuracy;Disease;Disease Marker;Disease Progression;dopaminergic neuron;drug discovery;Electroencephalography;entorhinal cortex;Event;Exhibits;Female;Future;genetically engineered virus;Goals;hindbrain;Histologic;Histopathology;Human;human old age (65+);hyperphosphorylated tau;Image;Impaired cognition;improved;in vivo imaging;Infection;Injections;knock-down;Knowledge;Lateral;Learning;Lesion;Life Expectancy;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;male;Measures;Methods;Midbrain structure;Modeling;Molecular;Molecular Profiling;Motor;motor deficit;motor disorder;Nerve Degeneration;neural network;Neural Pathways;Neurodegenerative Disorders;Neurons;Onset of illness;overexpression;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Patients;pedunculopontine tegmentum;Pharmaceutical Preparations;Pharmacotherapy;Physical therapy;Pontine structure;Population;pre-clinical;Process;programs;Progressive Supranuclear Palsy;protein aggregation;Protein Isoforms;Protein Overexpression;Proteins;proteostasis;Psyche structure;Rattus;Reflex action;REM Sleep;Reproducibility;Resolution;selective expression;Sensory;Sleep Deprivation;Slow-Wave Sleep;Structure;Substantia nigra structure;Symptoms;Syndrome;tau aggregation;tau dysfunction;tau mutation;tau Proteins;Tauopathies;Testing;Thalamic structure;Therapeutic;Time;Tissues;Universities;Ventricular;Wakefulness;Work

PROJECT_TITLE: Tau accumulation in the pedunculopontine tegmentum as an early node in Progressive Supranuclear Palsy pathogenesis

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative  Mutations in the Presenilins and the amyloid precursor protein (APP) are the genetic cause of Alzheimer’s disease. In this application we propose to develop Presenilin based novel therapies based on the knowledge we have gained during the last 25 years and to continue our investigation of the normal physiological role of APP family in the mammalian brain.

PI_NAMEs: SHEN, JIE  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: 2 year old;age related neurodegeneration;Aging;Alleles;Alzheimer's Disease;Amyloid beta-Protein Precursor;APLP1 gene;APLP2 gene;Apoptosis;Biochemical;Brain;Catalytic Domain;causal variant;Cell Culture Techniques;Cerebral cortex;Codon Nucleotides;Complementary DNA;conditional knockout;Data;Dependovirus;Development;Electrophysiology (science);excitatory neuron;Exhibits;familial Alzheimer disease;Family member;gamma secretase;Generations;Genes;Genetic;Genetic study;Gliosis;Hippocampus;Histologic;Human;Impairment;inhibitory neuron;Interneurons;Investigation;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Learning;Link;loss of function;Memory;Memory impairment;Modeling;Molecular;multidisciplinary;Mus;mutant;Mutant Strains Mice;Mutation;Nerve Degeneration;neuronal excitability;neuronal survival;Neurons;novel therapeutics;overexpression;Pathogenesis;Perinatal mortality demographics;Phenotype;Physiological;pre-clinical;preclinical study;presenilin;presenilin-1;promoter;Protein Family;Proteins;Recombinant adeno-associated virus (rAAV);Regulation;Role;secretase;Senile Plaques;Supporting Cell;Synapses;Synapsin I;synaptic function;Synaptic plasticity;System;Testing;Transgenic Mice;vector

PROJECT_TITLE: Presenilin and APP in the Brain


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Immunotherapy;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE Alzheimer’s disease (AD) and other neurodegenerative conditions are characterized by heightened inflammation, neurodegeneration, and CNS vascular permeability, including microhemorrhage formation. In this proposal, we employ novel transgenic mice that enable critical dissection of CD8 T cell recognition of antigen during priming and effector states in the CNS. We will test our central hypothesis that clonally expanded CD8 T cells engage brain vasculature and migratory antigen presenting cells during infiltration which contributes to neuropathology and cognitive deficits in AD and Tauopathies.

PI_NAMEs: JOHNSON, AARON J (contact)

PROJECT_TERMS: Ablation;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Antigen Presentation;Antigen-Presenting Cells;Antigens;APP-PS1;Area;Arizona;Attention;Authorship;Behavioral;Biological Models;blood-brain barrier disruption;Brain;brain cell;brain parenchyma;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell type;Cells;Cellular biology;cerebral atrophy;Cerebrovascular system;Clinic;Clonal Expansion;Cognitive deficits;Collaborations;conditional knockout;Core Facility;Dementia;Dendritic Cells;design;Development;Disease Outcome;Dissection;Documentation;effector T cell;Environment;Experimental Models;Funding;Gene Expression;Gene Expression Profiling;Goals;Grant;Granzyme;Hemorrhage;Histocompatibility Antigens Class I;Human;Image;Immune;Infection;Infiltration;Inflammation;innovation;Investigation;Joints;Knockout Mice;Knowledge;Macrophage;Magnetic Resonance Imaging;Manuscripts;Mechanics;Methodology;MHC Class I Genes;Microglia;Modeling;Monitor;mouse model;Mus;Nerve Degeneration;Nervous System Disorder;neuroinflammation;Neurons;neuropathology;NIH Program Announcements;novel;Parents;Patients;perforin;Phenotype;programs;Proteins;Recombinant adeno-associated virus (rAAV);Research;Research Personnel;response;Role;role model;Seminal;Severity of illness;System;T cell response;T-Lymphocyte Subsets;Tauopathies;Technology;Testing;Therapeutically Targetable;Transgenic Mice;Vascular Permeabilities;Well in self;Work

PROJECT_TITLE: Defining MHC class I restricted antigen presentation to CD8 T cells in experimental AD and Tauopathy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: AUGUSTA

ORG_DEPT: NEUROLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: The red blood cell plays an important role in oxygen delivery and blood flow to the brain. We are studying whether dysfunction of the red blood cell leads to dementia and cognitive problems. We will also study if physical exercise or a procedure called remote ischemic conditioning (applying a blood pressure cuff to the arm and repeatedly inflating and deflating it) improves red blood cell function and cognition and prevents dementia.

PI_NAMEs: HESS, DAVID C. (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: 5'-AMP-activated protein kinase;Affect;Age;age related;aged;Area;arm;arterial spin labeling;Attention;Bilateral;Biological Markers;Blood;Blood - brain barrier anatomy;Blood Cells;Blood flow;Blood Pressure;Brain;Brain Hypoxia;Carotid Stenosis;Cell Physiology;Cerebral small vessel disease;Cerebrovascular Circulation;Chronic;Cognition;Cognitive;Coupled;Data;Dementia;Diameter;Dose;Endocrine;Endothelial Cells;endothelial dysfunction;Enzymes;Erythrocytes;Erythroid;Event;Exercise;Female;Functional disorder;functional improvement;Goals;gray matter;Human;human subject;hypoperfusion;Hypoxia;Impaired cognition;Impairment;improved;indexing;Inflammation;Intracranial Medullary Artery;ischemic conditioning;Lesion;Limb structure;Location;Magnetic Resonance Imaging;male;Matrix Metalloproteinases;Measures;Mediating;Mediator;Microvascular Dysfunction;mimetics;Modeling;Molecular;Morphology;Mus;Mutant Strains Mice;neurovascular coupling;Nitric Oxide;Nitric Oxide Synthase;NOS3 gene;novel;Observational Study;Outcome;Oxygen;Patients;Perfusion;Physical Exercise;Play;preservation;prevent;Procedures;Production;Property;Research;Role;sensor;shear stress;Signal Transduction;Therapeutic;white matter;white matter damage;White Matter Disease;White Matter Hyperintensity

PROJECT_TITLE: Targeting RBC dysfunction in VCID

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEWARK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: Narrative Transcranial current stimulation is increasingly being used to alleviate the symptoms of depression, reduce epileptic seizures, and even to increase learning and cognition in healthy volunteers. However, little is known about the nature of the neural changes induced by transcranial currents. This project seeks to guide the refinement of transcranial current stimulation methods by determining how weak currents affect neural activity in mice.

PI_NAMEs: KREKELBERG, BART  (contact);POLACK, PIERRE- OLIVIER

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: Address;Affect;Anodes;awake;Behavior;behavioral outcome;Biology;Brain;BRAIN initiative;cell type;Cells;Cephalic;chronic pain;Clinic;Clinical;clinical application;Clinical Trials;Cognition;cognitive enhancement;Data;depressive symptoms;Development;Dose;Elderly;electric field;Electrodes;Elements;Epilepsy;experimental study;Explosion;Frequencies;Future;Genetic;Health;healthy volunteer;hippocampal pyramidal neuron;Home;Human;Human Subject Research;Image;Imaging Techniques;improved;in vivo;innovation;insight;Interneurons;Knowledge;Learning;Left;Location;Measures;Membrane Potentials;Mental Depression;Methods;Modeling;Motor Evoked Potentials;multi-electrode arrays;Mus;Nature;neural;neural circuit;neural stimulation;neuromechanism;Neurophysiology - biologic function;neuroregulation;Noise;novel;Outcome;Perception;Population;portability;post stroke;Process;Protocols documentation;Pyramidal Cells;Recovery;reduce symptoms;Reproducibility;Request for Applications;Research Personnel;research study;Resolution;response;Scalp structure;Short-Term Memory;success;Techniques;Technology;temporal measurement;Testing;two-photon;Variant;Visual Acuity;Visual Cortex;voltage sensitive dye;Work

PROJECT_TITLE: Neural Mechanisms of Transcranial Current Stimulation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Depression;Mental Health;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Exposure to repetitive head impacts (RHI) from contact sports has been associated with later life cognitive impairment, dementia, and neuropsychiatric disturbances including neurobehavioral dysregulation and depression. The etiology of these heterogeneous and non-specific symptoms is unclear and likely multifactorial. The proposed study will conduct sophisticated in vivo and ex vivo evaluations of white matter integrity and cerebrovascular disease to determine the vascular contributions to cognitive impairment, dementia and neuropsychiatric syndromes in diverse and well-characterized cohorts of contact sport athletes from two major research centers and a U54 collaborative brain bank initiative.

PI_NAMEs: ALOSCO, MICHAEL  (contact);MCKEE, ANN C.

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Affect;Age;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid beta-Protein;Anterior;arterial spin labeling;Arterioloscleroses;Axon;axon injury;Biological Markers;biomarker identification;Blood;Blood Vessels;blood-brain barrier disruption;Boston;Brain;California;Cerebral Amyloid Angiopathy;Cerebrovascular Disorders;chronic traumatic encephalopathy;Clinical;clinical conference;Cognition;Cognitive;Cognitive deficits;cohort;Collaborations;contact sports;Data;Data Set;Dementia;dementia risk;density;Deposition;Diffusion Magnetic Resonance Imaging;dosage;Dose;Enrollment;Enzyme-Linked Immunosorbent Assay;Etiology;Evaluation;Executive Dysfunction;executive function;Exposure to;Female;Frequencies;head impact;hypoperfusion;Immunofluorescence Immunologic;Impaired cognition;Impairment;in vivo;indexing;informant;Injury;Intervention;Interview;Iron;Late Effects;late life;Light;Literature;Magnetic Resonance Imaging;male;Manufactured football;Maps;Memory;Mental Depression;microvascular pathology;Myelin;Myelin Basic Proteins;neurobehavioral;Neurodegenerative Disorders;neurofilament;neuropsychiatric symptom;neuropsychiatry;novel;Oligodendroglia;Outcome;Participant;Pathologic;Pathology;Persons;Plasma;Play;Positioning Attribute;Predisposition;Protocols documentation;Race;Recording of previous events;recruit;Reporting;Research;resilience factor;response;Risk;Risk Factors;Sampling;San Francisco;Severities;sex;Spinal Puncture;Sports;Subgroup;Symptoms;Syndrome;tau Proteins;tau-1;Telephone;Testing;Thick;Traumatic Brain Injury;UCHL1 gene;Universities;Vascular Cell Adhesion Molecule-1;Vascular Cognitive Impairment;vascular contributions;Vascular Endothelial Growth Factors;vascular risk factor;white matter;White Matter Hyperintensity

PROJECT_TITLE: Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric Symptoms


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: TUCSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE The proposed research is relevant to public health as its goal is to develop new ways to use electrical deep brain stimulation for the precise control of tonic (slow) and phasic (fast) dopamine release in the brain. Disrupted tonic and phasic dopamine release underlies addiction, depression, Parkinson's disease, and schizophrenia, and improved control would therefore be relevant to translational research as new stimulation technologies could potentially treat these conditions. Thus, the proposed research is relevant to the NIH's mission to develop fundamental knowledge that can be applied to reduce human disability.

PI_NAMEs: COWEN, STEPHEN LEIGH (contact);HEIEN, MICHAEL L;LEWIS, TIMOTHY

PROJECT_TERMS: addiction;Affect;Anesthesia procedures;Behavior;Behavioral;Brain;Brain region;Cell model;clinical effect;Cognitive;Data;Decision Making;Deep Brain Stimulation;disability;Disease;Dopamine;Drug Addiction;Electric Stimulation;Electrical Stimulation of the Brain;Epilepsy;expectation;flexibility;Food;Frequencies;Goals;Human;human data;improved;innovative technologies;insight;Investigation;Knowledge;Learning;Link;mathematical model;Measurement;Measures;Medial;median forebrain bundle;Mental Depression;Methods;Mission;Modeling;Modernization;Motivation;motor control;multi-scale modeling;Nervous System Disorder;neural;neural stimulation;Neuromodulator;Neuronal Plasticity;Neurons;novel strategies;Nucleus Accumbens;optogenetics;Outcome;Parkinson Disease;Patients;Pattern;Periodicity;Phase;Physiologic pulse;Physiological;Pilot Projects;Play;Prefrontal Cortex;Process;Psychological reinforcement;Public Health;Rattus;Research;response;Reversal Learning;Rewards;Role;Scanning;Schizophrenia;Scientist;Shapes;Signal Transduction;Structure;Synapses;System;Technology;Testing;theories;Therapeutic;Time;tool;translational applications;Translational Research;Tremor;United States National Institutes of Health;Ventral Tegmental Area

PROJECT_TITLE: Control of the time course of dopamine release through optimized electrical brain stimulation.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The goal of the proposed research is to understand how beta-amyloid plaque, tau neurofibrillary tangle and alpha-synuclein Lewy body pathology interrelate in Lewy body dementias. This understanding will allow us and the field to develop new therapies for these dementias that target these interacting proteins.

PI_NAMEs: UNNI, VIVEK  (contact);WOLTJER, RANDALL L

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Acceleration;Alleles;alpha synuclein;Alpha-Synuclein transgenic mouse;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;beta amyloid pathology;Biochemical;Biological Assay;Brain;Cell Death;Cells;Central Nervous System;Clinical;Collaborations;Data;Dementia;Dementia with Lewy Bodies;Diagnosis;Disease;Electron Microscopy;Excision;Exhibits;extracellular;Functional disorder;Gastrocnemius Muscle;glial activation;Goals;Hindlimb;Hippocampus;human disease;imaging approach;Immune;in vivo;Individual;Injections;Laboratories;Lewy Bodies;Lewy Body Dementia;Lewy body pathology;Lewy Body Variant of Alzheimer's Disease;MAPT gene;Measures;Microglia;Modeling;mouse model;multiphoton imaging;multiphoton microscopy;Mus;Muscle;Nerve Degeneration;Nervous System;Neurons;neuropathology;novel strategies;novel therapeutics;Parkinson's Dementia;Pathology;Peripheral;Physiological;Play;pre-formed fibril;Process;Proteins;Research;Role;Senile Plaques;Synapses;synucleinopathy;tau aggregation;tau Proteins;Testing;Tissues;Toxic effect;Transgenic Mice;Work

PROJECT_TITLE: Mechanisms of spreading proteinopathy in Lewy Body Dementia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Albany

ORG_NAME: REGENERATIVE RESEARCH FOUNDATION

PHR: NARRATIVE Tauopathies such as Alzheimer’s Disease lead to brain cell dysfunction and degeneration and are a significant health concern today. We do not understand why some brain cell types are particularly affected while others are not. We will use human induced pluripotent stem cell derived neurons from patients suffering from early onset tauopathy to comprehensively study this question at cellular and molecular levels. Our goal is to identify ways in which brain cells are protected from disease as a key step towards developing cell-protective therapies.

PI_NAMEs: TEMPLE, SALLY  (contact)

PROJECT_TERMS: 26S proteasome;3-Dimensional;Affect;Alzheimer's Disease;Behavioral;Brain;brain cell;Brain region;Cell Communication;cell cortex;Cell Death;Cell Line;cell type;Cells;Cerebral cortex;Cognitive deficits;Collection;Complex;Computer software;Corpus striatum structure;Cytoprotection;Disease;dopaminergic neuron;Early identification;early onset;Engineering;Familial Dementias;Family;frontal lobe;Frontotemporal Dementia;Functional disorder;Gene Expression;Germ Cells;Glutamates;Goals;Health;Human;human induced pluripotent stem cells;hyperphosphorylated tau;Image;Impairment;improved;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Intrabody;Knowledge;Label;Language Disorders;Lead;MAPT gene;Midbrain structure;Modeling;Molecular;multicatalytic endopeptidase complex;mutant;Mutation;neuron loss;Neurons;Organoids;Parkinsonian Disorders;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Phenotype;Population;Prefrontal Cortex;prevent;Production;Prosencephalon;proteostasis;proteostasis loss;Reporter;Research;Resistance;response;RNA Splicing;Role;segregation;single-cell RNA sequencing;stressor;Substantia nigra structure;System;tau aggregation;tau Proteins;Tauopathies;Temporal Lobe;Testing;therapy development;Time;time use;transcriptomics;Ubiquitin;Variant;Visualization;Western Blotting

PROJECT_TITLE: Cell Type and Regional Vulnerability in Frontotemporal Dementia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Project Narrative Extracellular vesicles (EVs) carry Aβ and tau that may spread pathogenic proteins across the brain. The role of EVs in Alzheimer's disease is currently a major mystery of the disease mechanism and advancing mechanistic dissection of EV biology has been thwarted by a lack of tractable experimental animal systems. This research uses the powerful model system C. elegans to study the fundamental biology of neuronal EVs in vivo.

PI_NAMEs: BARR, MAUREEN M (contact)

PROJECT_TERMS: abeta accumulation;Acceleration;Address;Age;aged;Aging;aging brain;aging related disease;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid beta-Protein;Animal Experiments;Animals;Astrocytes;base;Biogenesis;Biological;Biological Assay;Biological Models;Biology;Blood;blood-brain barrier crossing;Brain;Caenorhabditis elegans;Candidate Disease Gene;Cell Culture Techniques;cell type;Cells;Cellular Stress;Cerebrospinal Fluid;Cilia;Clinical;Coculture Techniques;combat;Communication;Cultured Cells;design;Development;Disease;Dissection;Environment;extracellular;extracellular vesicles;frontier;Functional disorder;Gene Expression Profile;Genetic;Genetic Screening;Goals;Health;Health Promotion;Impaired cognition;in vivo;innovation;intercellular communication;Ischemia;knock-down;Knowledge;Measures;Mediating;Mediator;Microglia;Modeling;Molecular;Molecular Genetics;mutant;myelination;Nematoda;Nerve Degeneration;nerve stem cell;Nervous System;Neurodegenerative Disorders;Neuroglia;Neurons;neuroprotection;novel;novel therapeutics;Oligodendroglia;Oxidative Stress;Pathogenicity;Pathologic;Pathologic Processes;Pathway interactions;Patients;Physiological;Physiological Processes;Positioning Attribute;Production;Proteins;proteostasis;Reagent;Research;Role;Senile Plaques;sensory input;Signal Transduction;Site;Sphingomyelinase;stem cells;Stress;superresolution imaging;System;tau mutation;tau Proteins;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Up-Regulation;uptake;vesicular release;virtual;Visualization;Work

PROJECT_TITLE: Fundamental biology of neuronal extracellular vesicles

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ORG_CITY: FARMINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE The abnormal accumulation of amyloid peptides (Aβ) are linked to cause Alzheimer's cognitive dysfunction. Inhibition of BACE1, a critical enzyme for the generation of Aβ, may prevent and reduce Aβ generation to avoid excessive amyloid deposition. This study aims to test how BACE1 inhibition will be more effective in treating Alzheimer's patients. We aim to develop approaches that will enhance synaptic strength in addition to reduce Aβ generation. The obtained results will provide timely guidance for the safe and effective use of BACE1 inhibitors in human.

PI_NAMEs: YAN, RIQIANG  (contact)

PROJECT_TERMS: Abeta synthesis;Address;Adult;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Amyloid deposition;amyloid pathology;amyloid peptide;Animals;beta secretase;beta-site APP cleaving enzyme 1;Biochemical;Brain;Cells;Clinical;clinical application;Clinical Trials;Cognitive;cognitive function;Defect;Dementia;Development;Disease;Docking;Dose;Enhancers;Enzymes;epidemiology study;Equilibrium;experimental study;Functional disorder;Future;Generations;Genetic study;Goals;Hippocampus;Human;Human Genetics;Impaired cognition;Impairment;improved;in vivo;inhibitor;Knock-in;Knock-in Mouse;Knockout Mice;Knowledge;learned behavior;Link;Long-Term Depression;Long-Term Potentiation;Measures;Mediating;metabotropic glutamate receptor type 1;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;neurodevelopment;Neurologic Dysfunctions;Neurons;patch clamp;Pathogenesis;Pathologic;Patients;pharmacologic;positive allosteric modulator;postsynaptic;prevent;prodromal Alzheimer's disease;real-time images;Recovery;Reporter;Research;Role;side effect;Site;Slice;Synapses;synaptic function;Synaptic plasticity;Synaptic Potentials;Synaptic Vesicles;System;Testing;Toxic effect

PROJECT_TITLE: BACE1 in neurodegeneration and neurological dysfunction


ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

PHR: PROJECT NARRATIVE As sensory input changes through time, the sense of smell must track and represent these changes using a form of short-term memory. We will investigate how the mouse processes time-varying odor stimuli, and how neural circuits transform inputs into useful patterns of activity. Gaining insight may lead to better strategies for sensory prostheses and treating sensory deficits.

PI_NAMEs: SMEAR, MATTHEW C (contact)

PROJECT_TITLE: Ethologically relevant short term memory in the olfactory bulb


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Stroke, the leading cause of long-term adult disability, has no FDA-approved therapeutic treatments to boost long-term recovery in part because we do not understand long-term mechanisms that influence recovery. This research proposes to identify mechanisms of neurotrophin support by B cells, an immune cell subset that moves into uninjured areas of the post-stroke brain to support recovery. These studies will be critical in understanding how the immune system supports neuronal plasticity to improve long-term motor and cognitive recovery after stroke, with critical consideration of age and sex in the response of B cells to stroke.

PI_NAMEs: STOWE, ANN MARIE (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;adoptive B cell transfer;Adult;Affect;Age;age related;aged;aging population;Anatomy;Animals;Anxiety;Area;automated assessment;Automobile Driving;Award;B-Cell Acute Lymphoblastic Leukemia;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Brain;Brain region;Brain-Derived Neurotrophic Factor;Cell secretion;Cell surface;Cell Survival;Cells;Central Nervous System Diseases;central nervous system injury;Cognitive deficits;cognitive function;cognitive recovery;Data;Dementia;dentate gyrus;Development;disability;Elderly woman;excitotoxicity;extracellular;FDA approved;Female;Forelimb;functional plasticity;Genetic Polymorphism;Genetic Transcription;Glutamates;Growth Factor;Health;Hippocampus;Immune;Immune system;Impaired cognition;Impairment;improved;In Vitro;in vitro testing;Individual;Infarction;Infiltration;Interleukin-10;Ischemia;Ischemic Stroke;Learning;learning strategy;Leukocytes;Link;long term recovery;male;Mediating;Memory;Middle Cerebral Artery Occlusion;migration;Modeling;Motor;Motor Activity;Motor Cortex;motor deficit;motor function improvement;motor recovery;Mus;N-Methyl-D-Aspartate Receptors;neuroinflammation;Neuronal Plasticity;neuronal survival;Neurons;neuroprotection;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 2;novel;overexpression;patient population;Pattern;Population;post stroke;post stroke dementia;post stroke depression;preservation;primary outcome;Production;Publishing;Recovery;Recovery of Function;Recovery Support;reinforcer;Research;response;Risk Factors;rituximab;Role;sex;sham surgery;Signal Transduction;skills;Stimulus;Stroke;stroke model;stroke recovery;stroke risk;Support System;Synaptic Transmission;synaptogenesis;Tamoxifen;Techniques;Testing;Therapeutic;therapeutic target;tomography;touchscreen;two-photon;Up-Regulation;vascular cognitive impairment and dementia

PROJECT_TITLE: B Cells Directly Alter Adaptive Plasticity to Support Functional Recovery After Stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Tauopathies affect more than 6 million people in the US and include Alzheimer’s disease, progressive supranuclear palsy, and frontotemporal dementia. Tauopathies are the result of multifactorial processes that cause diverse changes in molecular networks linking a host of biological processes that lead to tau aggregates in the brain. This study will use stem cell, transcriptomic, and proteomic approaches to reveal novel mechanisms that drive tauopathy and can be targeted therapeutically.

PI_NAMEs: KARCH, CELESTE MARIE (contact)

PROJECT_TERMS: Affect;Alleles;Alzheimer's Disease;Antisense Oligonucleotides;Astrocytes;Binding;Biochemical;Biological Process;Brain;Brain region;brain tissue;Cell Nucleus;cell type;Cerebrospinal Fluid;Characteristics;Coculture Techniques;corticobasal degeneration;CRISPR/Cas technology;Defect;design;Disease;disorder risk;Dominant Genes;Enzymes;Equilibrium;Event;Exhibits;extracellular;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;Genes;Genetic;Goals;Half-Life;Haplotypes;Human;Impairment;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Inherited;Kinetics;Link;Lysosomes;Maps;MAPT gene;Metabolism;Methods;Modification;Molecular;Molecular Profiling;Monitor;mRNA Precursor;Mutagenesis;mutant;Mutation;Nerve Degeneration;Neuronal Dysfunction;Neurons;novel;novel therapeutic intervention;Pathogenesis;Pathologic;Pathway interactions;Persons;Phenotype;Process;Progressive Supranuclear Palsy;Proteomics;proteostasis;Risk;RNA Splicing;Stable Isotope Labeling;stem cells;Structure;targeted treatment;tau aggregation;tau expression;tau Proteins;tau-1;Tauopathies;Technology;Testing;Therapeutic;therapeutic target;transcriptome;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Targeting Tau Proteoforms in Frontotemporal Dementia

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: Our goal is to understand the genetic basis and neural circuits that govern social and collective behaviors in animals and to that end we picked schooling and shoaling in zebrafish as an example, because the larval form of the zebrafish is a very tractable model system in neuroscience, which means that their brains can be studied in great detail. Genes play important roles in controlling behavior, and genetic mutations are associated with neuropsychiatric diseases such as autism and schizophrenia, which are marked by deficits in social behaviors. We found that the mutations in some of these same genes also cause changes in social behaviors in adult and infant zebrafish, and we are now trying to find out what exactly is changed in the brains of these animals, and how these changes can explain the modified behaviors.

PI_NAMEs: ENGERT, FLORIAN  (contact);FISHMAN, MARK C

PROJECT_TERMS: Adult;Anatomy;Animals;autism spectrum disorder;Behavior;Behavior Control;Behavioral;Behavioral Assay;Behavioral Model;behavioral phenotyping;Biological Assay;Biological Models;Brain;Brain imaging;brain research;Calcium;Cells;Characteristics;Complex;Diffusion;DISC1 gene;Dissection;DNA Sequence Alteration;Elements;Embryo;Environment;Exhibits;Experimental Genetics;experimental study;Fishes;Five-Year Plans;Functional Imaging;Generations;Genes;Genetic;Genetic Transcription;Goals;Hand;Head;Image;Individual;Infant;Larva;Link;Location;mature animal;Membrane;migration;model organism;Modeling;Modification;Molecular;Motion;Motor;Movement;mutant;Mutation;neural;neural circuit;neural network;neuromechanism;Neurons;neurophysiology;neuropsychiatric disorder;Neurosciences;optogenetics;patch clamp;Pathway interactions;Performance;Phenotype;Physiological;Physiology;Play;Population;programs;Reflex action;Research;response;Role;Schizophrenia;Schools;social;Social Behavior;Social Interaction;Specificity;Stimulus;Structure;Study models;Swimming;Synapses;Technology;Testing;Time;virtual;visual motor;Zebrafish

PROJECT_TITLE: Genetic and neural mechanisms underlying emerging social behavior in zebrafish


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Regenerative Medicine

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Loss of stathmin-2 has emerged as a major pathological hallmark in several neurodegenerative conditions including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Using newly generated mouse models, we will test the impact of stathmin-2 loss on ALS and FTD and develop a therapeutic approach for sporadic and familial ALS/FTD based on antisense oligonucleotides (ASO)-mediated restoration of stathmin-2 level.

PI_NAMEs: CLEVELAND, DON W;LAGIER-TOURENNE, CLOTILDE  (contact);LUTZ, CATHLEEN M

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Adult;Affect;Alleles;alpha Tubulin;Alzheimer's disease patient;Amyotrophic Lateral Sclerosis;Animal Model;Animals;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Axon;axon regeneration;Axotomy;Binding;Binding Proteins;Binding Sites;C9ORF72;Chronic;Cognition Disorders;Collaborations;Cytoplasm;Development;Disease;falls;familial amyotrophic lateral sclerosis;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;Genetically Engineered Mouse;genome editing;granulin;Human;humanized mouse;in vivo;in vivo evaluation;in vivo Model;induced pluripotent stem cell;Industrialization;Inherited;Injections;insight;Introns;Lead;loss of function;Maintenance;Mediating;Messenger RNA;Modeling;Molecular;Motor;motor deficit;Motor Neuron Disease;Motor Neurons;mouse genome;mouse model;mRNA Precursor;Mus;Mutation;Natural regeneration;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;Neuromuscular Junction;neuron regeneration;neuronal growth;Neurons;novel therapeutic intervention;Nuclear;Pathogenesis;Pathologic;Pathology;Patients;PGRN gene;Phenotype;Polyadenylation;Pre-Clinical Model;premature;prevent;programs;protein TDP-43;Proteins;Regenerative capacity;restoration;RNA;RNA Processing;RNA Splicing;RNA-Binding Proteins;Rodent;Role;Site;small hairpin RNA;Spinal Cord;sporadic amyotrophic lateral sclerosis;stathmin;synergism;Testing;Therapeutic;therapeutic development;therapeutic effectiveness;therapeutic evaluation;therapy development;Tissues;Transcript

PROJECT_TITLE: In vivo modelling and therapy development for stathmin-2 loss in TDP-43 proteinopathies


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: Newark

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Lay Summary The heart becomes thicker in response to high blood pressure and other forms of stress in order to maintain its function of ejecting the blood to the whole body system. Together with coordinated stimulation of other mechanisms to ensure survival of heart cells and blood supply to them, this is an essential mechanism during the early phase of stress by which the heart maintains its function even in the presence of stress. We here study the mechanism by which the heart maintains its function in the presence of high blood pressure. We will test our hypothesis that a mechanism that stimulates the use of glucose for energy supply and production of building blocks coordinates the adaptation of the heart to stress so that the heart can continue to eject the blood. The knowledge obtained from this investigation should be useful in the development of novel interventions to protect the heart against stress.

PI_NAMEs: SADOSHIMA, JUNICHI  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: 3-phosphoglycerate;Acute;Address;Adult;aerobic glycolysis;Affect;Apoptosis;Binding;Blood;Body System;cancer cell;Cardiac;Cardiac Myocytes;Cell Death;cell growth;Cessation of life;ChIP-seq;Chronic Phase;cofactor;Complex;Development;Down-Regulation;Energy Supply;Ensure;Funding;Genetic Transcription;Glucose;Glycolysis;Glycolysis Induction;Goals;Growth;Heart;heart cell;Heart failure;Heart Hypertrophy;Hypertension;Hypertrophy;Hypoxia Inducible Factor;inhibition of autophagy;Intervention;Investigation;Knowledge;Laboratories;Maintenance;Mediating;Metabolic;Metabolism;metabolomics;Molecular;mouse model;Muscle Cells;Myocardial;Natural regeneration;novel;Nuclear;Organ Size;Pathogenesis;Pathway interactions;Phase;Phosphoenolpyruvate;Phosphotransferases;Play;pressure;Production;Proteins;Regulation;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;SLC2A1 gene;Sterility;Stress;Testing;transcription factor;Transcriptional Coactivator with PDZ-Binding Motif;transcriptome;tumorigenesis;Up-Regulation;upstream kinase;Vascular blood supply;Warburg Effect

PROJECT_TITLE: REGULATION OF MYOCARDIAL GROWTH AND DEATH BY THE HIPPO PATHWAY

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative Few longitudinal studies have explored why and how discrimination-related stressors for Latinx youth, the largest minority group (17.9 million under the age of 18), convey risk for negative mental health outcomes, and the mechanisms leading to or moderating such risk. This revised R01 aims to evaluate specific malleable risk and protective factors at multiple ecological levels so that findings can aid in the development of targeted, culturally sensitive preventive interventions.

PI_NAMEs: ALEGRIA, MARGARITA  (contact)

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: Acute;Address;Adolescent;Adult;Affect;Affective;Age;Anger;Area;Attention;Behavioral Mechanisms;Buffers;Characteristics;Chronic;Clinical;Cognitive;Communities;community collaboration;Conflict (Psychology);coping;Country;Criminal Justice;Data;design;Development;diaries;Dimensions;Discrimination;Education;emotion regulation;Ensure;Environment;ethnic discrimination;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;experience;Exposure to;Family;Fathers;Goals;Growth;Health;health disparity;health outcome disparity;Home;Human;Immigrant;improved;Indiana;Individual;innovation;Intervention;Investigation;Latino;Latinx;Latinx population;Life Cycle Stages;Link;Literature;Longitudinal Studies;marginalization;Mediating;Mediator;mental development;Mental Health;Methodology;Methods;Mexican;Mexican Americans;Migrant;migration;Minority;Minority Groups;Modeling;modifiable risk;Mothers;National Institute on Minority Health and Health Disparities;Neighborhoods;Outcome;Parents;Pathway interactions;peer;perceived discrimination;Persons;Predisposition;Prevention strategy;preventive intervention;Process;protective factors;Public Health;Puerto Rican;Race;racial discrimination;racial disparity;racial minority;racial minority population;racism;recruit;Research;Research Design;Research Priority;resilience;Resources;Risk;Risk Factors;Rural;Sampling;Schools;Seminal;Sleep;Sleep Disorders;social culture;Social Environment;social health determinants;Social Interaction;Social Mobility;Social status;Socialization;Stress;stressor;Surveys;Testing;Theoretical model;Time;Work;Youth

PROJECT_TITLE: Latino Youths Coping with Discrimination: A Multi-Level Investigation in Micro- and Macro-Time

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because one in five women in the U.S. is a sexual minority and, of the nearly 4 million births in U.S. each year, an estimated 800,000 children are born to sexual minority women. Sexual minority women and their children appear to be one of the most vulnerable maternal and child health populations, yet almost no research has documented their needs. Revealing the needs of at- risk groups—a major priority area for the NIH—will inform interventions to reduce entrenched disparities and dramatically improve obstetrical and perinatal health.

PI_NAMEs: CHARLTON, BRITTANY MICHELLE (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Adoption;aged;American;Area;Assisted Reproductive Technology;barrier to care;Behavior;Biological Markers;Birth;Bisexual;Child;child bearing;Child Health;cohort;Complex;Couples;Data;Data Collection;Data Set;Dimensions;Discipline of obstetrics;Disparity;Enrollment;Ethnic Origin;Evaluation;Event;Exclusion;experience;extreme prematurity;Female;Gays;gender minority group;Generations;Goals;Gynecologic;Health;health disparity;health disparity populations;Height;Heterosexuals;HIV/AIDS;Hydrocortisone;Hypertension;improved;infertility treatment;innovation;interest;intergenerational;Intervention;Knowledge;Legal;Lesbian;Lesbian Gay Bisexual;life span;longitudinal dataset;Low Birth Weight Infant;Maternal and Child Health;Mediator;men;Mental Depression;minority stress;Modeling;Mothers;neglect;Nurses;Nurses' Health Study;Obesity;offspring;Outcome;Parents;Participant;Pattern;Perinatal;perinatal health;perinatal outcomes;Policies;Politics;population health;Populations at Risk;Pregnancy;pregnancy disorder;prenatal;Public Health;Publishing;Race;Reporting;reproductive;Research;Resources;Rights;Riots;Risk;Risk Factors;same sex behavior;Same-sex;same-sex marriage;same-sex partnership;Sampling;sex;Sex Orientation;sexual assault;Sexual Health;sexual identity;sexual minority;sexual minority group;sexual minority health;sexual minority women;social;Sociology;Spontaneous abortion;stillbirth;Stress;Subgroup;substance use;Testing;unintended pregnancy;United States National Institutes of Health;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Sexual orientation-related disparities in obstetrical and perinatal health

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Opioids;Pain Research

ORG_NAME: CENTREXION THERAPEUTICS CORPORATION

PHR: PROJECT NARRATIVE This grant is aimed at the development of a novel, small molecule, nociceptin receptor agonist to be given intrathecally via an implanted microinfusion pump for the management of chronic severe intractable pain. The focus of this proposal is to complete IND-enabling CMC and preclinical toxicology studies, followed by a delayed onset Phase 1 trial in patients.

PI_NAMEs: CAMPBELL, JAMES N (contact)

PROGRAM_OFFICER_NAME: HACHICHA, MOHAMED

PROJECT_TERMS: Acute Pain;addiction;Address;Adverse effects;Agonist;alternative treatment;American;Analgesics;analog;analytical method;Behavioral;Biological;Blinded;Blood;Blood - brain barrier anatomy;Bolus Infusion;Brain;Bypass;Canis familiaris;Catheters;Chronic;Chronic low back pain;chronic pain;chronic pain management;Clinical;clinical development;combat;Consensus;Construction Materials;Data;Development;Devices;Dose;drug candidate;Drug Compounding;Drug Delivery Systems;drug production;Drug Stability;Ensure;Equilibrium;Equipment;Evaluation;FDA approved;first-in-human;Formulation;genotoxicity;Goals;Grant;Health;healthy volunteer;High Pressure Liquid Chromatography;Histopathology;Human;Implant;Implantable Pump;improved;Infusion procedures;Infusion Pumps;Intractable Pain;lipid solubility;Lumbar spinal cord structure;manufacture;manufacturing process;manufacturing scale-up;Maximum Tolerated Dose;Measures;Methods;Morphine;Mutagenicity Tests;Neurostimulation procedures of spinal cord tissue;non-opioid analgesic;nonhuman primate;novel;Operative Surgical Procedures;Opioid;opioid abuse;opioid epidemic;Organ;ORL1 receptor;Pain;pain patient;Pathology;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;phase 1 study;phase 2 study;Phase I Clinical Trials;phase I trial;Placebo Control;pre-clinical;Pre-Clinical Model;preclinical study;Preparation;Production;Property;Pump;Qualifying;Radiolabeled;Randomized;Rattus;receptor;Route;Running;Safety;Sampling;Sampling Studies;side effect;Site;small molecule;Spinal Cord;Systemic Therapy;Testing;Therapeutic;Toxic effect;Toxicity Tests;Toxicology;Translating;Urine;Validation;water solubility;Work;ziconotide

PROJECT_TITLE: Novel, Non-Opioid, Non-Addictive Intrathecal Therapy for the Treatment of Chronic Pain


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Each year in the United States, more than ~50,000 adults develop leukemia and more than half of these patients will die from their disease. Therefore, the need to increase research effort in this area is evident. We assembled a group of world renowned experts to form an Integrated Translational Science Center for Leukemia that selects and supports new ideas from outstanding US and international investigators that promises to revolutionary the current treatment approach to leukemia. This Center will work together with the National Clinical Trial Network and other initiatives sponsored by the National Cancer Institute

PI_NAMEs: BYRD, JOHN C. (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Achievement;Adult;adult leukemia;Area;Atmosphere;cancer type;Center for Translational Science Activities;Clinical;clinical translation;Clinical Trials;clinically relevant;Collaborations;community involvement;Creativeness;curative treatments;Data;design;Development;Disease;epigenetic marker;epigenomics;experience;Fostering;Funding;Genetic;Genetic Markers;genetic predictors;Genomics;Goals;improved;Individual;individualized medicine;Infrastructure;innovation;International;leukemia;leukemic transformation;leukemogenesis;Malignant Neoplasms;Molecular;Molecular Abnormality;Molecular Profiling;National Cancer Institute;National Clinical Trials Network;neoplastic;next generation;novel;Oncology;Outcome;participant enrollment;Patient-Focused Outcomes;Patients;Pharmacologic Substance;Phase;Pilot Projects;prognostic;programs;Protocols documentation;rational design;Research;Research Personnel;Sampling;Science;Southwest Oncology Group;System;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;Therapeutic Trials;therapy resistant;Tissues;Translating;translational medicine;treatment response;treatment strategy;tumor;United States;Work

PROJECT_TITLE: ITSC for Leukemia: Novel Molecular strategies for NCTN "Individualized" Therapies


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Maternal Health;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative We aim to establish the Health Outcomes around Pregnancy and Exposure to HIV/Antiretrovirals (HOPE) cohort to enroll and follow 2000 young women living with HIV (WLHIV), including those with perinatally acquired HIV (PHIV), to address critical scientific questions in the clinical course of HIV infection from preconception to postpartum. The cohort will be recruited from and build on the unique research infrastructure of the well- established Pediatric HIV/AIDS Cohort Study (PHACS) to create a platform for exploring the multilevel dynamic determinants and mechanisms that influence the short and longer-term health of WLHIV during their reproductive years.

PI_NAMEs: CHADWICK, ELLEN GOULD;KACANEK, DEBORAH ;POWIS, KATHLEEN ;WILLIAMS, PAIGE L (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: 18 year old;Address;Adherence;Adolescent;Affect;Age;antenatal;Anti-Retroviral Agents;antiretroviral therapy;Area;Attention;biobank;Birth;Caring;Child;Child Health;Child Rearing;Child Support;Clinical;clinical care;co-infection;cohort;comorbidity;Conceptions;Consequences of HIV;cost effective;Data;Data Collection;Diagnosis;Disclosure;Disease;Disease Progression;Enrollment;Ensure;epidemiology study;Epigenetic Process;Exposure to;follow-up;Foundations;Future;Genetic;Geography;Health;health assessment;health determinants;Health Status;Heterosexuals;HIV;HIV Infections;immune activation;Inequity;Inflammatory;Infrastructure;innovation;Institution;interest;Life Cycle Stages;life span;Link;Maternal Health;maternal outcome;Mental Depression;Mental Health;Methods;microbiome;Monitor;Mothers;multidisciplinary;Newly Diagnosed;Nulliparity;older women;Opioid;Oral health;Outcome;Participant;Pattern;Patterns of Care;Pediatric HIV/AIDS Cohort Study;Perinatal;Persons;physical conditioning;Population;Positioning Attribute;post pregnancy;postpartum care;Postpartum Period;Postpartum Women;Pregnancy;pregnant;Pregnant Women;prenatal exposure;prepregnancy;Prevalence;prospective;Proteome;Protocols documentation;psychosocial;Public Health;Puerto Rico;racism;recruit;reproductive;Reproductive Health;Research;Research Design;Research Infrastructure;Resources;Site;social stigma;Social support;substance use;therapy adherence;Time;transmission process;Treatment Factor;Treatment-related toxicity;United States;Viral;Viral Load result;virome;Virus;Woman;Women's Health;women's outcomes;women's reproductive health;young woman

PROJECT_TITLE: Health Outcomes around Pregnancy and Exposure to HIV/ARV (HOPE): Extending the Reach of PHACS to Examine Women's Health


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PI_NAMEs: MICOLI, KEITH J. (contact)

PROGRAM_OFFICER_NAME: DOYLE, JAMIE MIHOKO

PROJECT_TERMS: Acceleration;Accountability;Address;Applications Grants;Area;Basic Science;Behavioral;bench to bedside;career;career development;Characteristics;Clinical;clinical efficacy;Clinical Research;Clinical Sciences;clinically relevant;cohort;Collaborations;Communication;Communities;Competence;Creativeness;design;Development;Discipline;Doctor of Philosophy;drug development;economic evaluation;Economic Policy;Education;Educational Models;Educational process of instructing;Effectiveness;Exhibits;experience;Faculty;falls;Fostering;Funding;Future;Generations;Goals;Grant;Health;Health Policy;Health Services;Hospitals;implementation science;improved;Individual;innovation;interest;Knowledge;Lead;Learning;life span;Literature;Manuscripts;Mediation;Medicine;meetings;Mentors;Methodology;Mission;Modeling;multidisciplinary;National Center for Advancing Translational Sciences;National Research Service Awards;New York;next generation;novel strategies;Phase;Philosophy;Population;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Prevention;Process;Productivity;Program Development;programs;Research;Research Personnel;research to practice;Research Training;response;responsible research conduct;Science;Scientist;Self Perception;skills;Students;success;symposium;System;TNFSF15 gene;Training;Training Programs;trait;Translating;translational pipeline;Translational Research;translational scientist;Universities;Vision;Work;Writing

PROJECT_TITLE: NRSA Training Core


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Services;Prevention;Women's Health Research

ORG_CITY: BURLINGTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Breast cancer screening with mammography does not perform well for the many women who have dense breast tissue, but there are not clear guidelines regarding supplemental screening for these women. We will examine the effectiveness of supplemental ultrasound screening in clinical practice and estimate the long-term benefits, harms, and costs of screening strategies in which supplemental ultrasound is targeted to women with high rates of mammography screening failures. The results will reduce the burden of breast cancer among women for whom mammography screening is not adequate, by providing evidence for women, providers, and policymakers to inform breast cancer screening decision-making.

PI_NAMEs: SPRAGUE, BRIAN L (contact)

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: advanced breast cancer;Advanced Malignant Neoplasm;aged;Awareness;Biopsy;Breast;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Model;Breast Cancer Risk Factor;Breast Cancer Surveillance Consortium;breast density;breast exam;breast imaging;Cancer Detection;Cancer Intervention and Surveillance Modeling Network;Cancer Model;Characteristics;Clinic;Clinical;Clinical Data;clinical practice;clinical risk;comparative effectiveness;Computer Simulation;Confusion;cost;Data;Databases;Decision Making;density;Diagnostic Imaging;Digital Breast Tomosynthesis;Digital Mammography;Effectiveness;effectiveness evaluation;Evaluation;experience;Failure;Geography;Guidelines;Health Personnel;high risk;High Risk Woman;Image;improved;Laws;Letters;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Ultrasonography;Mammographic Density;Mammographic screening;Mammography;Medical Care Costs;Modality;models and simulation;mortality;multidisciplinary;neoplasm registry;network models;Notification;novel;Outcome;Pathology;Performance;performance tests;personalized screening;Policy Maker;Positioning Attribute;Provider;Quality-Adjusted Life Years;Radiology Specialty;Recommendation;Regional Cancer;Registries;Research Infrastructure;response;Risk;Risk Factors;screening;screening guidelines;supplemental screening;Techniques;Technology;Testing;ultrasound;United States Preventative Services Task Force;Woman;Work

PROJECT_TITLE: Identifying effective risk-based supplemental ultrasound screening strategies for women with dense breasts

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: In this study, we present preliminary data indicating that NKG2D signaling on CD8 T cells extends beyond the known canonical function (facilitating target recognition and favored killing), by providing pro-memory signals. This proposal will define the underlying players required for rpS6 phosphorylation downstream of NKG2D/DAP10 stimulation and its implications in the development of anti-tumor immunity and TRM cells.

PI_NAMEs: GUEVARA-PATINO, JOSE ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Accreditation;Agonist;Autologous;Automobile Driving;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell growth regulation;Cells;Cellular Structures;Certification;Clinical Trials;clinically relevant;Data;Defect;Development;Effector Cell;Engineering;experimental study;Failure;Flow Cytometry;FRAP1 gene;Gene Expression;Generations;Genetic;Goals;growth factor receptor-bound protein 2;Human;immune reconstitution;Immunologic Memory;Immunotherapy;Impairment;Individual;inhibitor;Intention;Interleukin-15;Intervention;Maintenance;Malignant Neoplasms;Melanoma;Memory;Microscopic;Modeling;Molecular;Monoclonal Antibodies;mouse model;Mus;overexpression;Pathway interactions;patient derived xenograft model;pharmacologic;Phase;Phosphorylation;precursor cell;Process;Production;Protein Biosynthesis;receptor;Repression;response;Ribosomal Protein S6;Role;Signal Transduction;SILV gene;Skin;Stat5 protein;T cell response;T memory cell;T-Lymphocyte;Testing;Therapeutic;Thymus Gland;Time;transcription factor;Transgenic Organisms;TSC1 gene;tumor;tumor growth;Tumor Immunity;tumor immunology;Tumor Tissue;Western Blotting;Work

PROJECT_TITLE: Study of Anti-Tumor Immunity and Tissue Resident Memory Cell Development by NKG2D and Ribosomal Protein S6 Signaling in T cells

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Parents of infants with neurologic conditions frequently face decisions about life and death. Under the guidance of my mentors, I will characterize how these choices are made and develop an intervention to improve how providers partner with parents to make decisions for neonatal neurology patients.

PI_NAMEs: LEMMON, MONICA  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: acceptability and feasibility;Agreement;arm;Award;Brain Injuries;career;career development;Caring;Cessation of life;Child;Clinical;cognitive testing;Communication difficulty;Complement;Conflict (Psychology);Data;Data Analyses;Decision Aid;Decision Making;Dedications;Development;Development Plans;disability;Enrollment;evidence base;experience;Face;Failure;Family;Feasibility Studies;feasibility testing;Frequencies;Gastrostomy;Goals;Impaired cognition;improved;Infant;Infant Care;Infant Mortality;infant outcome;instrument;Intensive Care Units;International;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;language impairment;Life;Measures;Medical;meetings;Mentors;Mentorship;Methodology;Methods;Morbidity - disease rate;motor impairment;Neonatal;neonate;Nervous System Disorder;Neurologic;Neurology;Outcome;Parents;Patients;Physicians;Positioning Attribute;preference;Process;Prognosis;prognostic;programs;prospective;Provider;provider communication;randomized trial;Randomized, Controlled Trials;Regrets;Research;satisfaction;Scientist;shared decision making;skills;Surveys;symposium;Testing;Time;tool;Tracheostomy procedure;Training;Tube;usability;Work

PROJECT_TITLE: Decision Making for Infants with Neurologic Conditions

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative To address persistent and growing health and healthcare disparities, efforts are urgently needed to build the capacity and diversity of the research workforce. Applying integrative health approaches to advance optimal health for all is a promising, but under-studied strategy. The proposed program will strengthen the research workforce by providing diverse, predoctoral learners with a much-needed career on-ramp: short-term, interprofessional research training in integrative medicine, focused on social disparities in health and healthcare.

PI_NAMEs: ADLER, SHELLEY R;CHAO, MARIA T (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Acupuncture Therapy;Applied Research;California;career development;Clinical Research;Complementary Health;Dedications;Discipline of Nursing;diversity and inclusion;Education;Educational Curriculum;Ethical Issues;experience;Faculty;Goals;Health;health care disparity;health disparity;health equity;Health Occupations;Healthcare;Integrative Medicine;Medicine;Mentors;Methodology;Naturopathy;Osteopathic Medicine;Pathway interactions;Pharmacy facility;pre-doctoral;programs;Public Health;Ramp;recruit;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Role;San Francisco;skills;social;social disparities;summer institute;Training;Training and Infrastructure;Training Programs;Universities

PROJECT_TITLE: Summer Institute on Integrative Health Equity and Applied Research (IHEAR)


NIH_SPENDING_CATS: Cancer;Immunotherapy;Microbiome;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Defining host-intrinsic mechanisms associated with immune failure could lead to the development of immune therapies capable of eliciting anti-tumor immune reactivity across a broad range of cancer types. We identify that chronic signaling through TLR5 on host cells impairs myeloid function and reduces the ability of T cells to respond during immune therapy for ovarian, breast, and melanoma cancers. This research will define the mechanisms of TLR5-induced myeloid dysfunction and failure of PD-L1 blockade, the impact of which could establish inhibition of TLR5 signaling as a novel therapeutic for multiple malignancies.

PI_NAMEs: RUTKOWSKI, MELANIE R (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Ablation;adaptive immunity;Address;Affect;Anatomy;Animals;autocrine;Bacteria;Breast;Breast Cancer Model;cancer type;Cell Physiology;Cells;Chronic;commensal bacteria;Complementary therapies;cytokine;Data;Dendritic Cells;Development;Disease;Disease remission;Endowment;exhaustion;Failure;Foundations;Functional disorder;Gene Expression;Goals;host microbiome;Immune;immune function;immune resistance;Immune System Diseases;Immunosuppression;Immunotherapy;Impairment;In Vitro;in vivo;Infiltration;inhibitor;insight;Interleukin-12;Interleukin-6;Intrinsic factor;Knockout Mice;Knowledge;Label;Leaky Gut;Ligands;Macrophage;Malignant Neoplasms;Mammary Neoplasms;Mediating;Melanoma;Melanoma Tumor;Metabolic;microbiome;microorganism;Modeling;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;novel therapeutics;Outcome;Ovarian;ovarian neoplasm;Paralysed;Pathologic;Patients;PD-L1 blockade;Peptidoglycan;Phenotype;pressure;Primary Neoplasm;Production;Recurrent disease;Reporter;Repression;Research;Resistance;response;Role;Signal Induction;Signal Pathway;Signal Transduction;Solid;Solid Neoplasm;T-Lymphocyte;Testing;therapeutic evaluation;therapy development;TLR5 gene;Treatment Efficacy;tumor;Tumor Escape;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor stage;Tumor-associated macrophages;Wild Type Mouse

PROJECT_TITLE: TLR5 signaling as a conserved mechanism of impaired anti-tumor immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LOUISVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: Project Narrative The University of Louisville COBRE in Functional Microbiomics, Inflammation and Pathogenicity is a unique thematic research center. COBRE scientists comprise a multidisciplinary group of senior mentors and junior investigators on a pathway to independence, who are focusing on diseases that involve complex interactions between microbial challenge and host inflammatory responses. Outcomes of this research may lead to the development of novel therapeutic agents and delivery systems to protect against a number of chronic and difficult to treat conditions.

PI_NAMEs: LAMONT, RICHARD J (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Acceleration;animal facility;Autoimmune Diseases;Basic Science;Bioinformatics;Biological Assay;Biometry;career;career development;Career Mobility;Centers of Research Excellence;Chronic;Communities;Complex;Dedications;design;Development;Disease;Ensure;Environment;Environmental Risk Factor;Evaluation;experience;Extramural Activities;Faculty;Funding;Germ-Free;Goals;graduate student;Health;Health Transition;Homeostasis;host-microbe interactions;Human;Human body;Human Microbiome;imaging capabilities;Immune response;Immune system;immune system function;Immunologics;Immunology;Infection;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Infrastructure;innovation;Institution;interdisciplinary approach;Interdisciplinary Study;International;intravital microscopy;Location;Mentors;Methods;microbial;microbial community;Microbiology;microbiome;microbiome research;microbiome sequencing;microbiota;Mucous Membrane;multidisciplinary;Natural Immunity;novel;novel therapeutics;Outcomes Research;pathogen;Pathogenicity;Pathway interactions;Phase;Pilot Projects;Postdoctoral Fellow;Process;programs;Qualifying;recruit;Regulation;Renaissance;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;response;Scientist;senior faculty;Site;Specificity;Structure;success;synergism;System;Talents;Technology;Therapeutic Agents;Tissues;Training;Universities;whole animal imaging


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases;Microbiome

PROJECT_TERMS: Acceleration;Address;Administrative Efficiency;Advisory Committees;Area;Biometry;Book Chapters;Budgets;Cancer Center;cancer immunotherapy;career;career development;Centers of Research Excellence;Clinical;Collaborations;commercialization;Communicable Diseases;Credentialing;data acquisition;Development;Development Plans;Disease Outcome;Ensure;Evaluation;Evaluation Research;expectation;experience;Faculty;faculty mentor;Funding;Goals;graduate student;Grant;Growth;Guidelines;Human Microbiome;Human Resources;Immunology;Inflammation;Inflammatory;Inflammatory Response;Institution;International;Journals;Leadership;meetings;Mentors;Microbiology;microbiome research;multidisciplinary;Nature;oral immunology;oral infection;Pathogenicity;Phase;Pilot Projects;Positioning Attribute;Preparation;Process;programs;Qualifying;Records;recruit;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Resolution;Services;Structure;student training;success;symposium;Toxicology;tumor immunology;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: FMIP COBRE Administrative Core


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Dissemination and Implementation Research;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Physical Activity;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE Function focused care is an approach to care in which nurses acknowledge older adults’ physical and cognitive capabilities and integrate physical activity into all care interactions. This care approach prevents the decline in function, limited physical activity, behavioral and psychological symptoms, among other adverse outcomes in hospitalized patients with Alzheimer’s Disease and Related Dementias (ADRD). Our goal in this work is to demonstrate the efficacy of a practical and effective intervention, FFC-AC-EIT, to optimize function and physical activity and prevent adverse events among hospitalized patients with ADRD.

PI_NAMEs: BOLTZ, MARIE ;RESNICK, BARBARA  (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Acute;acute care;Admission activity;Adverse event;adverse event risk;adverse outcome;Age;Age Years;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;associated symptom;Bathing;Bed rest;Beds;Behavioral Symptoms;Belief;care coordination;caregiving;Caring;Cognitive;comorbidity;cost;Cost Savings;Cues;Deep Vein Thrombosis;Deimplementation;Delirium;Dementia;disability;Discipline of Nursing;Disease;Education;Educational process of instructing;effective intervention;efficacy testing;Emergency department visit;Environment;Event;experience;Fall prevention;fall risk;falls;Family;fear of falling;Friends;Fright;functional decline;Goals;Health care facility;Healthcare Systems;Home environment;hospital readmission;Hospitalization;Hospitals;human old age (65+);implementation framework;implementation intervention;improved;Individual;innovation;Institutionalization;Knowledge;Length of Stay;Licensed Practical Nurse;Long-Term Care;Maryland;Medical;medication administration;Mental Depression;Mentors;Methods;Modeling;Moods;Motivation;Movement;novel strategies;Nurses;Nursing Staff;older adult;older patient;Outcome;Pain;Patient Care;patient engagement;Patient Participation;Patient Recruitments;Patients;Pennsylvania;person centered;Physical activity;Physical assessment;Physical Function;physical inactivity;Pilot Projects;Pneumonia;Policies;post implementation;prevent;Prevention;Process;psychological symptom;Quality of life;Randomized;readmission rates;Recovery;Recreation;recruit;Registered nurse;relative cost;Research;Resources;Risk;Sampling;social;social cognitive theory;Sterile coverings;System;Testing;Training;Urinary tract infection;vehicular accident;Walking;willingness;Work

PROJECT_TITLE: Testing the Efficacy of FFC-AC-EIT in Patients with Alzheimers Disease and Related Dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Microbiome;Neurodegenerative

PI_NAMEs: BODDULURI, HARIBABU  (contact)

PROJECT_TERMS: 3xTg-AD mouse;Administrative Supplement;Adopted;aging related;Alzheimer's Disease;animal facility;Area;Award;Behavior;Bioinformatics;Biological;Blood - brain barrier anatomy;Breeding;cancer immunotherapy;Centers of Research Excellence;clinical translation;Core Facility;Data Analyses;Dedications;Derivation procedure;Development;Edible Plants;Equipment;exosome;experimental study;Extramural Activities;Fee-for-Service Plans;Fostering;Funding;Future;Genomics;Germ-Free;Gnotobiotic;Goals;Histopathology;Housing;Image;imaging facilities;in vivo imaging system;Individual;Inflammation;Inflammation Mediators;Infrastructure;innovation;Institution;intravital microscopy;Joints;Knockout Mice;Laboratories;Mentors;metabolomics;Methodology;microbiome research;microbiota;microscopic imaging;Mission;Modeling;morris water maze;mouse model;multi-photon;Mus;nanopore;National Institute of General Medical Sciences;novel;object recognition;Pathogenesis;Pathogenicity;Phase;Play;Process;programs;protocol development;Protocols documentation;Research;Research Personnel;Research Project Grants;Research Support;Resources;Ribosomal DNA;Role;Sampling;Services;success;synthetic polymer Bioplex;System;Techniques;Testing;Tissues;tool;Training;Training and Education;Transgenic Organisms;Translational Research;tumor immunology;Universities;Whole Organism;Work

PROJECT_TITLE: Functional Microbiomics Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Understanding how neurons mediate perception is an important step towards developing effective treatments for pathologies that disrupt perception. The proposed experiments exploit the model system of color vision, one of the most mature submodalities of vision, to reveal the neural events that relate activation of the peripheral receptors to perception.

PI_NAMEs: HORWITZ, GREGORY D (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: accurate diagnosis;Affect;Appearance;area V1;behavior measurement;Behavioral;Biological Models;Calcium-Binding Proteins;Categories;cell type;Cells;Cerebral cortex;Code;Color;Color blindness;Color Perception;color processing;Color Visions;Complex;Cone;Contrast Sensitivity;Data;Data Pooling;Devices;discrimination task;Disease;Dissociation;effective therapy;Electrophysiology (science);Event;experience;experimental study;Goals;Human;imaging Segmentation;information processing;inhibitory neuron;Interneurons;Joints;Judgment;Knowledge;knowledge of results;Lighting;luminance;Macaca;Maps;Mediating;Methods;Modeling;Monkeys;Nervous System Disorder;neural;Neurons;Noise;nonhuman primate;novel;Output;Parvalbumins;Pathology;Pattern;Perception;Performance;Peripheral;Phase;phenomenological models;Photoreceptors;Physiological;Physiological Processes;Primates;Process;Property;Psychophysics;receptive field;receptor;Recovery;Reporting;Research;Resolution;response;Role;Signal Transduction;spatial relationship;spatiotemporal;Stimulus;Sum;System;Testing;theories;Time;Trauma;V1 neuron;Viral Vector;Vision;visual neuroscience;Visual System

PROJECT_TITLE: Central mechanisms of color vision

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Narrative Understanding the mechanisms of cell migration is a fundamental question in cell, developmental and cancer biology. Cells in vivo travel through confining three-dimensional (3D) pores or channel-like tracks created by various anatomical structures in the body. We will herein utilize state-of-the-art bioengineering, materials and imaging tools as well as in vivo models to offer a comprehensive understanding of the mechanisms driving cell locomotion in physically-confined spaces and provide insights for developing technologies that can control, manipulate, promote or stop cell migration in vivo.

PI_NAMEs: KONSTANTOPOULOS, KONSTANTINOS  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: 3-Dimensional;Actomyosin;Alginates;Anatomy;anillin;Anions;Automobile Driving;Biochemical;Biological Process;Biomedical Engineering;Bulla;Cancer Biology;cell motility;Cell Nucleus;Cell Volumes;Cells;Cellular biology;Collagen;Confined Spaces;Cues;Cytokinesis;Cytoplasm;Cytoskeleton;Data;Developmental Biology;Dimensions;Disease;Disease Progression;Distant;Embryonic Development;Event;Extracellular Matrix;Fiber;Gel;Goals;Health;Human;Imaging Device;In Vitro;in vivo;in vivo Model;insight;Invaded;Ion Channel;knock-down;Lamin Type A;Light;mechanical properties;Mechanical Stress;Mechanics;mechanotransduction;Mediating;Microfluidics;migration;Modeling;Molecular;Myosin Type II;Nerve;novel;Nuclear;Nuclear Translocation;optogenetics;Organism;Pathway interactions;Pattern;Phenotype;Physiological;polyacrylamide;pressure;Process;Property;Regulation;response;Role;Rupture;Scaffolding Protein;Speed;Supporting Cell;Surface;System;Technology;Testing;Tissues;tool;Travel;viscoelasticity;Visualization;Work;Yeasts

PROJECT_TITLE: Cell mechanobiology in confinement using an integration of bioengineering, materials systems and in vivo models

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Pharmaceutical drug discovery produces dramatic public health beneﬁts through new and improved treatments for common diseases and disorders, but it is an expensive, time-consuming process involving much trial and error, and failure is common. This work focuses on automated, iterative computational design of new drugs, allowing tight coupling of modeling and experiment to dramatically accelerate the discovery and development process. Improved modeling techniques help guide experimental work, and experimental outputs feed back into rapidly improved designs, with the resulting discovery pipeline providing public health rewards both in terms of new technology and via discovery of new potential antibacterials.

PI_NAMEs: MOBLEY, DAVID LOWELL (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Active Learning;Affinity;Anti-Bacterial Agents;Area;Automation;Back;Binding;Biological Assay;blind;combinatorial;common treatment;Communities;Computational Technique;Computer software;computerized tools;Computers;Computing Methodologies;Consumption;cost;Coupled;Coupling;Databases;design;Development;Disease;DNA;drug discovery;Engineering;experimental study;Failure;Free Energy;guided inquiry;Health Benefit;improved;interest;Investments;iterative design;Laboratories;lead optimization;Libraries;Ligands;Machine Learning;Medicine;Methods;model design;Modeling;new technology;novel;novel therapeutics;open data;open source;Oral;Output;Pharmacologic Substance;Play;Process;process optimization;Proteins;Public Health;Recommendation;Research;Research Personnel;Resources;Rewards;Science;screening;Screening Result;Series;Solubility;Structural Biologist;Techniques;Therapeutic;Time;tool;Vision;Work

PROJECT_TITLE: Accelerating drug discovery via ML-guided iterative design and optimization

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

PI_NAMEs: MORADALI, FATA  (contact)

PROJECT_TERMS: Adenosine;Adenosine Monophosphate;Adult;Agonist;alveolar bone;Anaerobic Bacteria;antagonist;Anti-Inflammatory Agents;Applications Grants;Bacteria;Biological;Bone Resorption;Cell membrane;Cell Physiology;Cells;Chemical Structure;Chronic;Communities;cytokine;Cytoprotection;Data;Detection;Development;Disease;Disease Progression;Equilibrium;Etiology;Foundations;Genes;Gingiva;Heterogeneity;Human;Immune;Immune Evasion;Immune system;immunoregulation;In Vitro;in vitro testing;in vivo evaluation;in vivo Model;Infection;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Innate Immune System;Learning;Lipopolysaccharides;macromolecule;Membrane;microbiome research;Microinjections;Modeling;Molecular;Mus;mutant;new therapeutic target;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathologic;Pathway interactions;Periodicity;Periodontal Pocket;Periodontitis;phosphoric diester hydrolase;Play;Porphyromonas gingivalis;Production;Property;Protein Isoforms;receptor;Regulation;response;Role;Serum;Signal Pathway;Signal Transduction;Stimulus;Stress;Structure;System;Systemic disease;Therapeutic;Tissues;TLR4 gene;Toll-like receptors;Tooth Loss;Tooth structure;Variant;Virulence;Virulence Factors;Virulent

PROJECT_TITLE: Regulation of LPS structure and function in Porphyromonas gingivalis


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition

PI_NAMEs: COLLINS, JAMES TRISTAN (contact)

PROJECT_TERMS: Accounting;Adult;Antibiotics;Biological Assay;Bioreactors;Carbohydrates;Clostridium difficile;colonization resistance;Communities;Data;Development;Diet;Dietary Sugars;Disease;dysbiosis;Enabling Factors;Environment;Environmental Risk Factor;Epidemic;evidence base;Future;Gastrointestinal tract structure;Genes;Goals;Growth;gut microbiota;Healthcare;healthcare-associated infections;Horizontal Disease Transmission;Hospitalization;Hospitals;host microbiota;Human;human old age (65+);In Vitro;Incidence;Infection;Inflammation;innovation;insight;Intake;Intervention;Intestines;Invaded;Link;Metabolic;Metabolism;microbiome research;microbiota;Modeling;Modernization;mouse model;Mouse Strains;new therapeutic target;novel;Nutrient;Nutrient availability;Organism;Outcome;pathogen;Pathogenicity;Persons;Population;prevent;Process;Production;prophylactic;Prophylactic treatment;Research;Role;Severity of illness;Shapes;Solid;Specificity;sugar;System;Testing;Toxic effect;Toxin;treatment strategy;Trehalose;Virulence;Work

PROJECT_TITLE: The role of sugar transport in C. difficile colonization and disease


NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Complementary and Integrative Health;Dietary Supplements;Microbiome;Nanotechnology;Natural Products;Neurosciences;Nutrition

PI_NAMEs: TENG, YUN  (contact)

PROJECT_TERMS: Acids;age-related disease;aged;aging process;aging related;Alzheimer's Disease;Apoptosis;Bacteriophages;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier function;blood-brain barrier permeabilization;Brain;Brain Diseases;brain dysfunction;Brain Injuries;Chronic;cognitive recovery;Communication;Data;Development;Disease;Edible Plants;Effectiveness;Elements;Encephalitis;Endothelial Cells;exosome;Family;Foundations;Gene Expression;Genes;Ginger;Goals;Growth;Growth Factor;gut dysbiosis;gut microbiota;gut-brain axis;Health Benefit;Human;Impaired cognition;Impairment;improved;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Intervention;Intranasal Administration;Learning;Mediating;Medicine;Memory;microbial;microbiome research;Microglia;MicroRNAs;Modeling;Molecular;mouse model;Myoviridae;nanoparticle;nerve stem cell;neuroinflammation;neuronal survival;Neurons;new therapeutic target;novel;old mice;oligodendrocyte progenitor;Oral;Oral Administration;Pathogenicity;Pathway interactions;Physiological;Plants;precursor cell;prevent;Prevention strategy;Process;Production;Publishing;rate of aging;receptor;Reporting;Role;Route;S100A8 gene;Shapes;side effect;Surface;Synaptic plasticity;Testing;Tight Junctions;TLR4 gene;Tumeric

PROJECT_TITLE: Edible Plant-derived exosome-like nanoparticles (ELNs) and phage inhibit brain inflammation by targeting microglia and  gut microbiota


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative.  One of the most complex issues associated with Substance Use Disorder (SUD) treatment, is the development of strategies that assist in the initiation and maintenance of recovery following addiction. To add further intricacy, there are substantial sex differences indicating women may face significantly more hurdles in maintaining drug abstinence, compared to men. Thus, understanding mechanisms of sex differences in addiction is critical to the development of effective therapies for SUDs.

PI_NAMEs: KOHTZ, AMY  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;addiction;Address;Animal Model;Automobile Driving;awake;Basic Science;Behavior;Behavioral;Behavioral Model;Bioinformatics;Biological;biological adaptation to stress;Clinical Research;Clinical Treatment;cocaine exposure;cocaine seeking;cocaine self-administration;Complex;conditioned place preference;craving;Dependence;designer receptors exclusively activated by designer drugs;Development;Dorsal;drug abstinence;Drug Addiction;drug of abuse;drug seeking behavior;drug standard;Drug Targeting;Drug usage;effective therapy;Electrophysiology (science);experimental study;Extinction;Face;Faculty;Female;functional genomics;Gene Expression Profile;Gene Targeting;Genes;Genetic;Genetic Techniques;Goals;Hippocampus;Home;Human;Institution;Intervention;Link;locus ceruleus structure;Maintenance;Maintenance Therapy;male;men;Methods;Molecular Profiling;neural;neural circuit;neural recruitment;Neuronal Plasticity;Neurons;neuroregulation;new therapeutic target;noradrenergic;novel;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacogenetics;Phase;Population;Positioning Attribute;Pre-Clinical Model;programs;promoter;psychologic;Rattus;Recovery;recruit;Relapse;relapse prediction;Research;resilience;Resistance;response;Risk;Rodent;Rodent Model;Role;sex;Sex Differences;Signal Pathway;Signal Transduction;substance abuse treatment;Substance Use Disorder;success;Techniques;tenure track;Testing;therapeutic target;Time;Trademark;Training;Transcript;transcriptome;transcriptome sequencing;Woman;women versus men

PROJECT_TITLE: Sex Differences in Addiction