ADMINISTERING_IC: AT

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Chronic Pain;Complementary and Integrative Health;Natural Products;Neurosciences;Pain Research

ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Over the past 25 years, the search for novel analgesics has had only a few successes and many failures; some of these failures have occurred through an overreliance on screening of compounds in rodent models of pain or physiology that fail to translate to homo sapiens. In this proposal, we take a target agnostic but human centric approach to discover novel natural product fractions with potential to induce analgesia through peripheral nociceptors. Natural product fractions from the National Cancer Institutes Natural Products Repository will be screened for analgesic activity in human “nociceptor” cells using multi-electrode array technology.

PI_NAMEs: DUSSOR, GREGORY O;KOLBER, BENEDICT J (contact);PANCRAZIO, JOSEPH J.

PROGRAM_OFFICER_NAME: HOPP, CRAIG

PROJECT_TERMS: Absence of pain sensation;Action Potentials;Acute Pain;Address;Afferent Neurons;Agonist;Analgesics;Anatomy;Animals;antagonist;Baclofen;Basic Science;Behavior;Biochemical;Biological Assay;Biology;Capsaicin;Cell Physiology;Cells;Chili Pepper;chronic pain;cytokine;Data;Development;efficacy study;Electrodes;Electrophysiology (science);Ethics;Evaluation;Event;Failure;Genes;Heterogeneity;high throughput screening;Home;Homo sapiens;Human;human induced pluripotent stem cells;In Vitro;in vivo;Inflammatory;inflammatory pain;inhibitor;innovation;Interleukin 6 Receptor;Interleukin-6;Libraries;marine organism;Measures;Methods;Modeling;Modernization;Molecular Target;mouse model;multi-electrode arrays;Mus;National Cancer Institute;Natural Products;Natural Source;Neurons;Nociception;Nociceptors;novel;Operative Surgical Procedures;opioid epidemic;Organ Donor;Organism;Pain;pain model;Paper;patch clamp;Patients;Peripheral;pharmacologic;Pharmacology;pharmacophore;Phase;Phenotype;Physiological;Physiology;Plants;pre-clinical;Process Assessment;Proteins;Publishing;Rattus;repository;Research;Rodent;Rodent Model;screening;single cell sequencing;Sorting;Source;Speed;Spinal Ganglia;Stimulus;success;Technology;Testing;Therapeutic;tool;transcriptome;transcriptome sequencing;transcriptomics;Translating;Translations;TRPV1 gene

PROJECT_TITLE: High content analgesic screening from human nociceptors

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: GALVESTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Innovative and integrated approaches are needed to enhance our understanding of the biology of psychiatric disorders. Toward this goal, we will synthetize and validate new chemical probes targeting a protein-channel interaction complex that regulates neuronal firing. We will utilize these probes as research tools to interrogate the circuitry of the nucleus accumbens and advance the molecular and cellular understanding of psychiatric disorders and addiction.

PI_NAMEs: LAEZZA, FERNANDA  (contact);ZHOU, JIA

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: absorption;Action Potentials;Acute;addiction;Affect;Anhedonia;Behavior;behavior test;Behavioral;Binding;Biological;Biological Assay;Biology;Bioluminescence;blood-brain barrier permeabilization;Brain;Brain Diseases;Cardiac;cell type;Cells;Central Nervous System Agents;Chemicals;Classification;Clinical;clinical efficacy;Collection;Communities;Complement;Complex;design;Development;Disease;Dose;Drug Design;drug discovery;Drug Kinetics;Electrophysiology (science);Excretory function;fibroblast growth factor-14;flexibility;Fluorescence;Foundations;Functional disorder;gamma-Aminobutyric Acid;Genetic;Globus Pallidus;Goals;hedonic;high throughput screening;improved;in vitro activity;in vivo;innovation;intermolecular interaction;Ion Channel;Knowledge;Lead;Ligand Binding;Ligands;Link;loss of function;Luciferases;luminescence;Manuals;Measures;Mental disorders;Metabolic;Metabolism;Molecular;Molecular Probes;motivated behavior;Motivation;Mus;mutant;nanomolar;Nature;Nervous System;neural circuit;neuronal excitability;Neurons;Neuropharmacology;neuropsychiatric disorder;novel;novel therapeutic intervention;Nucleus Accumbens;optogenetics;Outcome;Output;patch clamp;Pathway interactions;Permeability;pre-clinical;Process;Protein Isoforms;protein protein interaction;Proteins;psychologic;receptor;Regulation;Research;response;Rewards;Role;SCN8A gene;Slice;small molecule;small molecule libraries;Solubility;Surface Plasmon Resonance;Therapeutic;therapeutic development;tool;Toxic effect;Transgenic Mice;Validation;validation studies;Ventral Tegmental Area;voltage

PROJECT_TITLE: Probing brain circuit and behavior with protein:protein interaction modulators

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: OMAHA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Staphylococcus spp. are important components of the human skin microbiota and perform important functions including protection against pathogens and appropriate immune response development. However, we have little understanding as to how Staphylococcus spp. adhere to the skin surface. Experiments proposed in this application are designed to test the hypothesis that Staphylococcus spp. adhere to skin via a conserved rod-like cell wall protein called Aap/SasG.

PI_NAMEs: FEY, PAUL D (contact);HERR, ANDREW B;HORSWILL, ALEXANDER R

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Adherence;Adhesions;antimicrobial;Atomic Force Microscopy;Binding;Biological Assay;Biology;biophysical properties;Cell Wall;Coagulase;commensal bacteria;Data;design;Development;Disease;experimental study;Family member;Genus staphylococcus;Glycoproteins;Goals;Human;human pathogen;Human Volunteers;Immune response;Immune system;Immunocompromised Host;Infection;Knowledge;Lectin;Ligand Binding;Ligands;Link;Mammals;Mediating;Membrane Proteins;Modality;Modeling;mouse model;Mucous Membrane;novel therapeutics;pathogen;Polysaccharides;protein function;Protein Region;Proteins;prototype;Publishing;Rod;Role;Site-Directed Mutagenesis;Skin;Skin colonization;skin microbiota;sortase;Specificity;Staphylococcal Infections;Staphylococcus aureus;Staphylococcus epidermidis;Staphylococcus hominis;Structure;Surface;Systems Development;Techniques;Testing

PROJECT_TITLE: Mechanisms of staphylococcal skin colonization

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE This application requests five years of support to continue a highly successful annual addiction meeting that brings together a diverse group of addiction researchers, clinicians, educators, and policymakers, including many young investigators and individuals from underrepresented populations. The meeting explores novel targets and approaches for treating substance use disorders, encourages young investigators to commit to a career in addiction research, and annually publishes a proceeding of the plenary symposium. This NIH grant along with significant donations support a generous travel program that makes attendance at the BBC possible for young, aspiring addiction researchers.

PI_NAMEs: FRANCE, CHARLES P (contact)

PROGRAM_OFFICER_NAME: LE, HOANG VAN

PROJECT_TERMS: addiction;Advertising;African American;Alcohol dependence;Applications Grants;Appointment;Area;Award;Behavior;Biology;career;career development;Chemistry;Clinical Research;Collaborations;cost;cost effective;Creativeness;Data;Dedications;demographics;Development;Drug Addiction;Educational workshop;Electronic Mail;Eligibility Determination;Faculty;Feedback;Fees;Fellowship;Fostering;Funding;Future;graduate student;Grant;Hearing;High School Student;Hispanic;Individual;Institution;International;lectures;Manuscripts;Medicine;meetings;member;Minority-Serving Institution;multidisciplinary;Native Americans;novel;Oral;oral communication;Pamphlets;Pathway interactions;Patient Self-Report;Personal Communication;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Policies;Policy Maker;post-doctoral training;Postdoctoral Fellow;posters;programs;Psychiatrist;Publishing;recruit;Request for Applications;Research;Research Personnel;Science;Scientist;Senior Scientist;Substance Use Disorder;supportive environment;Surveys;symposium;Techniques;Texas;Thinking;Translational Research;Translations;Transportation;Travel;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Behavior, Biology, and Chemistry: Translational Research in Addiction


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Prevention;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative / Relevance Genetic research for psychiatric disorders has achieved remarkable advances in narrowing down regions of the genome that increase risk. However, the exact mechanism for why certain individuals are at higher risk than others remains unknown. The goal of this grant is to identify, characterize, and validate functional noncoding mutations that contribute to schizophrenia. Understanding how specific DNA variants directly contribute to psychiatric disorders will be critical for developing improved diagnostics and treatment therapies.

PI_NAMEs: CRAWFORD, GREGORY E (contact);GERSBACH, CHARLES A.;SULLIVAN, PATRICK F

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: 3-Dimensional;Address;Alleles;ATAC-seq;autism spectrum disorder;Awareness;Binding;Binding Proteins;Binding Sites;Biological;Biological Assay;Biology;Body mass index;Brain;brain control;Brain region;brain volume;Cell Nucleus;cell type;Cells;ChIP-seq;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Consensus;Data;Development;Diagnosis;Diagnostic;disorder risk;Disparate;diverse data;DNA;Elements;Enhancers;Epigenetic Process;epigenome;epigenome editing;excitatory neuron;exome sequencing;Exons;follow-up;functional genomics;Funding;Gene Expression;Genes;Genetic;genetic architecture;genetic association;Genetic Research;Genetic Risk;Genetic Variation;Genome;genome editing;genome wide association study;genomic data;Genomics;Goals;Grant;Haplotypes;Heritability;Hi-C;high risk;histone modification;Human;human induced pluripotent stem cells;improved;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;innovation;insight;Intervention;Investigation;Knowledge;Machine Learning;Magnetic Resonance Imaging;Mental disorders;Motivation;mouse model;Mutation;nerve stem cell;Neurons;Non-Insulin-Dependent Diabetes Mellitus;Organoids;Pathway interactions;patient derived induced pluripotent stem cells;Pattern;pharmacologic;Phenotype;promoter;protein protein interaction;Proteomics;psychiatric genomics;psychogenetics;Quantitative Trait Loci;Regulatory Element;Repression;Research;Risk;risk variant;Schizophrenia;schizophrenia risk;Science;screening;single cell ATAC-seq;single-cell RNA sequencing;Solid;Sweden;Synapses;Tail;technology development;Testing;Therapeutic;trait;transcription factor;Translating;Untranslated RNA;Update;Validation;Variant;Work

PROJECT_TITLE: Beyond GWAS: High Throughput Functional Genomics & Epigenome Editing to Elucidate the Effects of Genetic Associations for Schizophrenia


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative  Chronic liver disease (CLD) is a common cause of illness and death worldwide, and it is a significant healthcare and financial burden. Liver fibrosis (LF) is a measurable feature of CLD that is important to assess the severity of disease, evaluate for progression and therapy response, and predict outcomes. We propose to apply artificial intelligence methods to noninvasive conventional magnetic resonance images and readily- available clinical data for accurate detection and quantification of LF, thus significantly impacting public health by facilitating personalized therapies without the need for liver biopsy, improved outcomes, and lower healthcare costs.

PI_NAMEs: HE, LILI  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: accurate diagnosis;accurate diagnostics;Address;Adult;Age;American;Appearance;artificial intelligence method;Bilirubin;Biopsy;Black Box;Body mass index;Cessation of life;Characteristics;Child;Childhood;Chronic Disease;chronic liver disease;classification algorithm;Clinical;Clinical Data;clinical risk;Complex;Computer-Assisted Diagnosis;convolutional neural network;cost;Crowding;Data;Data Set;Databases;Death Rate;Decision Making;Dedications;deep learning;deep learning model;deep neural network;Descriptor;Detection;Diabetes Mellitus;Diagnosis;diagnostic technologies;Disease;Evaluation;Eye;fatty liver disease;Financial Hardship;Goals;Health Care Costs;Health Expenditures;healthcare burden;Histologic;hospital readmission;hospitalization rates;Human;Image;improved;improved outcome;Individual;Institution;Laboratories;Learning;Length of Stay;life time cost;Liver;liver biopsy;Liver Fibrosis;liver stiffness;liver transplantation;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Maps;Mathematics;Measurable;Measures;Medical;Modeling;Morbidity - disease rate;Morphology;mortality;mortality risk;multimodality;multitask;Neural Network Simulation;non-linear transformation;Operative Surgical Procedures;Outcome;outcome prediction;Patient-Focused Outcomes;Patients;Pattern;Performance;personalized diagnostics;personalized medicine;Physicians;Population;Portal Hypertension;Procedures;prognostic model;prognostication;Property;Public Health;radiologist;radiomics;Reference Standards;Research;Research Personnel;Residual state;Risk;Risk Factors;Running;Sampling Errors;Series;Severity of illness;sex;Shapes;Signal Transduction;Site;Spleen;Staging;Structural defect;Techniques;Testing;Texture;Time;Tissues;Training;Transplantation;treatment response;Vendor;Viral hepatitis;Visual;Workload

PROJECT_TITLE: Quantification of Liver Fibrosis with MRI and Deep Learning

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE This proposal aims to define the gene regulatory network (GRN) that underlies the primordial lung progenitor, the epithelial progenitor with the broadest competency in the respiratory system. Understanding and manipulating the primordial lung progenitor GRN can lead to the robust and efficient derivation of different types of functional respiratory epithelial cells from patient-specific induced pluripotent stem cells (iPSCs). Our studies will advance iPSC-based therapies for and in vitro modeling of diseases affecting the lung epithelium, such as chronic obstructive pulmonary disease (COPD), cystic fibrosis and alpha-1 antitrypsin deficiency.

PI_NAMEs: IKONOMOU, LAERTIS  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Address;Adult;Affect;Air;airway epithelium;alpha 1-Antitrypsin Deficiency;Alveolar;alveolar epithelium;Animal Model;Anterior;apoAI regulatory protein-1;ATAC-seq;Autologous;beta catenin;Binding;Binding Sites;Biological Assay;Cell Line;Cell Lineage;Cell Transplantation;cell type;Cells;ChIP-seq;Chromatin;Chronic Obstructive Pulmonary Disease;Clinical;clinical application;clinically relevant;Competence;Complex;Computer Models;Computing Methodologies;Coupled;CRISPR interference;CRISPR-mediated transcriptional activation;Cystic Fibrosis;Data;Dependence;Derivation procedure;Development;differentiation in vitro;differentiation protocol;directed differentiation;Disease;disease model;Distal;DNA Binding;Embryo;embryo tissue;Embryonic Development;Endoderm;endogenous stem cells;Epigenetic Process;epigenomics;Epithelial Cells;epithelial stem cell;Epithelium;Ethical Issues;Flow Cytometry;FOXP2 gene;gain of function;gene function;gene regulatory network;Genetic;genetic manipulation;Genetic Models;Genetic Transcription;genome wide association study;Goals;Heterogeneity;homeodomain;Human;human pluripotent stem cell;immunocytochemistry;Immunohistochemistry;In Vitro;in vitro Model;in vivo;individualized medicine;induced pluripotent stem cell;induced pluripotent stem cell technology;insight;knock-down;Knowledge;Lead;Link;Liquid substance;loss of function;Lung;lung development;Lung Diseases;Maps;Mediator;Modeling;Morphology;mouse genetics;mouse model;multimodality;Mus;mutant;novel;Nucleic Acid Regulatory Sequences;Organism;overexpression;Pathway interactions;Patients;Pattern;Pluripotent Stem Cells;Population;preimplantation;Primitive foregut structure;Primordium;Process;progenitor;programs;Prosencephalon;pulmonary function;Regenerative Medicine;Regulation;Reporter;Respiratory System;Role;self-renewal;Signal Transduction;single-cell RNA sequencing;Sorting;spatiotemporal;Specific qualifier value;stem cell differentiation;stem cell genes;stem cell therapy;stem cells;System;Techniques;Testing;Thyroid Gland;Time;Tissues;tool;transcription factor;transcriptome sequencing;transcriptomics;Transplantation;WNT Signaling Pathway;Work;zygote

PROJECT_TITLE: Gene regulatory networks in early lung epithelial cell fate decisions

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Orphan Drug;Rare Diseases

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE We discovered gain-of-function mutations in the human ornithine decarboxylase 1 (ODC1) gene, now known as Bachmann-Bupp Syndrome (BABS) that present with global developmental delays, hair loss, and dysmorphic features. Similarly, Snyder-Robinson Syndrome (SRS) is a rare neurodevelopmental disorder defined by loss-of-function mutations in the spermine synthase (SMS) gene. The overall goal of this application is to elucidate the underlying molecular mechanisms of BABS and SRS using both existing and new murine disease models as well as patient-derived cells, blood, and tissue samples for in-depth studies, providing essential information for advancement of effective new therapies for these human genetic disorders.

PI_NAMEs: BACHMANN, ANDRE S (contact);BUPP, CALEB ;CASERO, ROBERT A.

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Adult;Affect;Aftercare;analog;Animal Model;Animals;autosome;Behavioral;behavioral response;Biochemical;Biochemical Pathway;Biochemistry;Biological Assay;Biology;Blood specimen;C-terminal;Cell Line;Cells;Clinical;clinical care;Clinical Data;CRISPR/Cas technology;Data;Data Analyses;de novo mutation;design;Diagnosis;differential expression;Disease;disease model;DL-alpha-Difluoromethylornithine;Dominant Genetic Conditions;Dose;Drug Kinetics;Effectiveness;effectiveness testing;Eflornithine;eIF-5A;Enzymes;Family;FDA approved;gain of function;gain of function mutation;Gene Mutation;Genes;Genetic;Genetic Diseases;genetic testing;genetic variant;genome editing;global developmental delay;Goals;Hair;Heterozygote;Histology;Human;Human Genetics;improved;In Vitro;in vivo;Individual;inhibitor;Intervention;Lead;Light;Link;loss of function;loss of function mutation;lymphoblastoid cell line;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;Molecular;Monitor;mouse model;Mus;Mutation;Neurodevelopmental Disorder;Neurology;Newborn Infant;novel;novel therapeutics;Ornithine Decarboxylase;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phenotype;Plasma;Polyamines;Publishing;Putrescine;Rare Diseases;reduce symptoms;Regulation;response;Sampling;screening;Sentinel;Skin;Snyder-Robinson syndrome;Spermidine;Spermine;Spermine Synthase;Symptoms;Syndrome;targeted agent;Testing;The Jackson Laboratory;Therapeutic;Tissue Sample;Tissues;tool;transcriptome;transcriptomics;Transgenic Organisms;Treatment Effectiveness;treatment response;Variant;Whole Blood

PROJECT_TITLE: Leveraging modulation of polyamine metabolism for therapeutic advantage in genetic disorders

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Genetics;Infectious Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE This project tests a hypothesis that interaction of genetic and environmental risks such as pathogen infection impair Paneth cell heterogeneity and induction of proper innate immune response, which are vital for protecting against intestinal inflammation. The project will combine genetically engineered mouse models, pathology analysis of Crohn’s disease patient tissues, and microbiome association in gnotobiotic mice to investigate how healthy vs. dysbiotic microbiota differentially affect Paneth cell populations, IBD initiation and progression.

PI_NAMEs: GAO, NAN  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Ablation;Address;Affect;anti-microbial peptide;antimicrobial;Autophagocytosis;Cells;Chromatin;Clinical;Crohn's disease;Cytokine Receptors;Cytoplasm;Cytoplasmic Granules;Data;Defect;design;Diffusion;Disease;disease model;Disease remission;Disease susceptibility;dysbiosis;endoplasmic reticulum stress;Environmental Risk Factor;Epigenetic Process;Etiology;Exhibits;Experimental Designs;experimental study;fecal transplantation;Gene Expression Profile;Genetic;Genetic Risk;genetic risk factor;Genetically Engineered Mouse;Germ-Free;Gnotobiotic;gut inflammation;gut microbiota;Heterogeneity;Homeostasis;Human;Immune;Immune response;Immunologics;Impairment;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;innate immune function;Innate Immune Response;innate immune sensing;innovation;Intervention;Intestines;Label;Lesion;Link;Maps;Mediating;microbiome;microbiota;microbiota transplantation;Modeling;Molecular;mouse model;Mucous Membrane;Mus;novel therapeutics;Onset of illness;Outcome;overexpression;Paneth Cells;pathogen;Pathogenesis;Pathology;Pathway interactions;Patients;Phenotype;Play;Population;Production;Recurrence;Refractory;Relapse;Reporter;Reporting;Research Personnel;response;Role;Secretory Vesicles;Severities;Small Intestines;standard care;standard of care;Testing;Tissues;transcriptomics;treatment response;Ulcerative Colitis;Untranslated Regions

PROJECT_TITLE: Paneth cell heterogeneity in infection and inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(57)]


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

PHR: This research will identify personalized genetic profiles of people at risk, protection, and resilience against AD and vascular traits, the role of the AD risk and other factors in these profiles, and new mechanistic links between genes, intermediate traits, AD, and vascular diseases. These results have implications for identifying personalized interventions and natural (e.g., life style) factors helping to ameliorate or avoid AD and vascular diseases, and for development of personalized therapeutic strategies.

PI_NAMEs: KULMINSKI, ALEXANDER M (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Address;Affect;Age;age related;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Bioinformatics;Biological;Biology;Birth;Blood Glucose;Blood Pressure;Blood Vessels;Body mass index;Cardiovascular Diseases;Characteristics;Cholesterol;cognitive performance;cohort;Complex;Data;density;Development;Diastolic blood pressure;Disease;disease phenotype;Education;Environmental Exposure;Epigenetic Process;Ethnic Origin;exome;Gene Expression;Genes;Genetic;genetic association;Genetic Predisposition to Disease;Genetic Transcription;genetic variant;genome wide association study;genome-wide analysis;Genotype;Goals;Haplotypes;Heterogeneity;High Density Lipoproteins;Hypertension;improved;indexing;Individual;insight;Intervention;Life;Life Style;Link;Linkage Disequilibrium;Lipids;lipoprotein cholesterol;Low-Density Lipoproteins;Mediation;Meta-Analysis;Methods;Methylation;Molecular Analysis;Molecular Profiling;non-genetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Onset of illness;Pathway interactions;Pattern;personalized intervention;personalized therapeutic;Persons;Physical activity;polygenic risk score;Populations at Risk;precision genetics;protective factors;Proxy;Quantitative Trait Loci;Race;rare variant;reproductive;Research;resilience;Resources;Risk;Risk Factors;Role;Sampling;sex;Smoking;Statistical Methods;statistics;Stroke;Structure;trait;Triglycerides;Variant;Vascular Diseases;vascular risk factor;Work

PROJECT_TITLE: Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(51)]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative We will investigate the mechanism by which HIV-1 recruits key host factors to its capsid to ensure effective completion of early steps of infection. Structural and functional insights into critical virus-host interactions will facilitate ongoing efforts in the pharmaceutical industry to develop improved, long-acting, highly active antiretroviral therapies.

PI_NAMEs: KVARATSKHELIA, MAMUKA  (contact);MELIKIAN, GREGORY B

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: activation-induced cytidine deaminase;Affinity;base;Binding;Binding Proteins;Binding Sites;Biochemistry;Biological Assay;Biology;Capsid;Capsid Proteins;Cell Nucleus;Cells;cofactor;Complement;Complex;Cone;Coupled;Cryoelectron Microscopy;Cytoplasm;Cytoplasmic Protein;Dependence;Drug Industry;Ensure;Event;experimental study;Foundations;frontier;Future;Genetic Code;Glycine;Goals;Highly Active Antiretroviral Therapy;HIV-1;Hydrophobicity;improved;In Vitro;Infection;inhibitor;insight;Integration Host Factors;integration site;Knowledge;Label;Life Cycle Stages;live cell microscopy;Mediating;Molecular;Molecular Mechanisms of Action;Monitor;next generation;novel;novel virus;Nuclear Import;Nuclear Pore Complex;Peptides;Phase III Clinical Trials;Phenylalanine;prion-like;Productivity;Proteins;Proteomics;Recombinants;recruit;Reporting;retrograde transport;Role;Shapes;spatiotemporal;structural biology;structural determinants;Surface;synergism;Testing;therapeutic target;Time;trafficking;Tube;Tubular formation;Viral;virology;Virus;virus host interaction;Work;X-Ray Crystallography

PROJECT_TITLE: Roles of HIV-1 capsid-binding FG-motif containing cellular cofactors in infection

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: The locus coeruleus norepinephrine (NE) system exerts widespread neuromodulatory influence in the brain, but its function in behavior remains elusive, due mostly to a lack of circuit level analysis. Here, we will use cutting-edge approaches to elucidate the causal contribution and computational role of local and output circuits of the locus coeruleus in mice. Such information is critical for understanding the function of NE in cognition, and for providing strong mechanistic basis for its dysfunction in neuropsychiatric disorders.

PI_NAMEs: SUR, MRIGANKA  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Address;Anatomy;Animals;Anxiety;Arousal;Auditory;Axon;Behavior;Behavior Control;behavior measurement;Behavioral;Behavioral Paradigm;Brain;Brain region;Brain Stem;Cell Nucleus;cell type;Cerebellum;Cognition;Computer Analysis;Data;Disparate;Dissociation;Electrophysiology (science);Exhibits;Functional disorder;gamma-Aminobutyric Acid;genetic manipulation;Head;Image;Immunohistochemistry;inhibitory neuron;innovation;insight;instrument;Kinetics;Knowledge;learned behavior;Learning;locus ceruleus structure;Measures;Monitor;Motor;Motor Cortex;Mus;Negative Reinforcements;Neuromodulator;Neurons;neuropsychiatric disorder;neuroregulation;Norepinephrine;norepinephrine system;novel;Opsin;Optics;optogenetics;Output;Phase;Population;Positive Reinforcements;Prefrontal Cortex;Process;Prosencephalon;Psychological reinforcement;Punishment;response;Rewards;Role;segregation;sensor;Sensory;Signal Transduction;Source;spatiotemporal;Spinal Cord;Stimulus;Task Performances;Techniques;Testing;theories;Tissues;Training;two-photon;Uncertainty;Viral

PROJECT_TITLE: Spatiotemporal dynamics of locus coeruleus circuits during learned behavior

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Messenger RNA (mRNA) vaccines are a new and potent vaccine platform that can confer elevated protection from SARS-CoV-2 infection. Since the durability of protective immune responses and the mechanism of action of SARS-CoV-2 mRNA vaccines are currently undefined, we aim to shed light on these important topics. The knowledge acquired here will inform boosting strategies for SARS-CoV-2 vaccines, as well as rational vaccine design for new and difficult-to-neutralize pathogens.

PI_NAMEs: LOCCI, MICHELA  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Address;Affinity;Antibodies;Antibody Affinity;Antibody Response;Antibody titer measurement;Antibody-Producing Cells;Antigen Presentation;Antigen-Presenting Cells;Antigens;Applications Grants;B-Cell Activation;B-Lymphocytes;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Shape;cell type;Complex;COVID-19 vaccine;cytokine;Dendritic Cells;Encapsulated;Endowment;Ensure;Epitopes;Event;FDA Emergency Use Authorization;Fostering;Future;Generations;Helper-Inducer T-Lymphocyte;Human;Immune response;Immunoglobulin-Secreting Cells;Individual;Infection;innovation;Knowledge acquisition;Label;Length;Licensing;lipid nanoparticle;Longevity;Mediating;Membrane;Memory B-Lymphocyte;Messenger RNA;Molecular Conformation;mouse model;Mus;Names;Nature;neutralizing antibody;novel vaccines;Nucleosides;pandemic disease;pathogen;Pathway interactions;Plasma Cells;Process;programs;Proteins;Race;rational design;Reaction;Regulation;response;RNA vaccination;RNA vaccine;SARS-CoV-2 infection;Secondary Immunization;secondary lymphoid organ;Speed;Structure of germinal center of lymph node;Technology;Testing;Time;Toll-like receptors;Vaccination;Vaccine Design;vaccine development;vaccine distribution;vaccine platform;Vaccines

PROJECT_TITLE: Regulation of germinal center responses by SARS-CoV-2 messenger RNA vaccines

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Physical Activity;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Drug abuse is a major public health concern, but currently, there are few effective treatments for managing drug craving and preventing relapse to drug use. Aerobic exercise is a promising treatment, but its precise mechanism of action is unknown. This project will help define the neurochemical and neurophysiological mechanisms that critically mediate the therapeutic effect of exercise on drug addiction and relapse.

PI_NAMEs: ZLEBNIK, NATALIE  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Aerobic Exercise;Animals;Attenuated;Behavior;Behavior Therapy;Brain;cell type;Chronic;Cocaine;cocaine relapse;cocaine related behaviors;cocaine reward;cocaine seeking;cocaine self-administration;Corpus striatum structure;craving;Cues;Data;Development;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;Dorsal;Drug abuse;Drug Addiction;drug craving;drug of abuse;drug relapse;Drug usage;effective therapy;Effectiveness;Electrophysiology (science);Environment;Event;examination questions;Exercise;experimental study;Exposure to;Extinction;extracellular;Genetic;Goals;Human;in vivo;insight;Intake;Intervention;Kinetics;Maintenance;Mediating;Methods;Molecular;motivated behavior;mouse model;Mus;neural;Neurobiology;neurochemistry;Neurons;neurophysiology;novel;Optics;optogenetics;paired stimuli;Periodicity;Pharmaceutical Preparations;Pharmacotherapy;Phase;prevent;Process;prolonged abstinence;Public Health;receptor expression;Recording of previous events;recruit;Relapse;relapse prevention;Reporting;response;restoration;reward circuitry;Rodent;Role;Running;Scanning;sedentary;Signal Transduction;Slice;spatiotemporal;Technology;Therapeutic;Therapeutic Effect;Titrations;Treatment Efficacy;uptake;Ventral Striatum;Withdrawal

PROJECT_TITLE: Effects of exercise on dopaminergic mechanisms of cocaine relapse


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  The proposed project will address fundamental issues for reconstruction and inference of high-dimensional causal networks, then apply the developed new methodology to the elucidation of causal genetic variants, genes, and risk factors for Alzheimer's disease (AD) with potential applications to other common illnesses. Thus it will facilitate their prevention, early diagnosis, and therapeutic development.

PI_NAMEs: PAN, WEI ;SHEN, XIAOTONG TOM (contact)

PROJECT_TERMS: Algorithms;Alzheimer's Disease;Alzheimer's disease risk;Biological;Biological Models;Biotechnology;causal variant;Communities;Complex;Computer software;computerized tools;Computing Methodologies;Data;Data Analyses;deep neural network;Development;Disease;Documentation;Early Diagnosis;Environment;Equation;Etiology;Gene Expression;gene regulatory network;Genes;Genetic Diseases;genetic variant;genome wide association study;genome-wide;Genomics;Genotype;Graph;high dimensionality;innovation;instrument;interest;Intervention;Investigation;Least-Squares Analysis;Lipids;Literature;Mendelian randomization;Methodology;Methods;Modeling;multidimensional data;neural;Neurodegenerative Disorders;novel;Pathway interactions;phenotypic data;pleiotropism;power analysis;Prevention;Process;programs;Public Domains;Pythons;reconstruction;Regulatory Pathway;Research;Research Personnel;Risk Factors;Role;Sample Size;scalable algorithms;Scheme;Single Nucleotide Polymorphism;software development;Statistical Computing;Statistical Methods;Testing;theories;therapeutic development;tool;trait;transcriptome;treatment strategy;Uncertainty;web site;Writing

PROJECT_TITLE: Estimation and inference in directed acyclic graphical models for biological networks

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Washington

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: AMERICAN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The proposed project will explore how an intergenerational intervention could improve approaches to the management of HIV and related co-morbidities among older adults living with HIV (OPLHV) in South Africa by employing youth in their communities to offer multi-dimensional support, thereby addressing the lack of HIV care and treatment interventions targeting the rapidly growing older population.

PI_NAMEs: ANGOTTI, NICOLE C (contact);GOMEZ-OLIVE CASAS, FRANCESC XAVIER

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adult;Affect;Africa;Africa South of the Sahara;African;Age;aged;Aging;aging in place;aging population;antiretroviral therapy;Caring;Chronic;Chronic Disease;Communities;comorbidity;Cross-Sectional Studies;Data;Dimensions;disability;Disease;Early Intervention;Epidemic;evidence base;experience;Face;Family;Family Caregiver;Financial Contribution;Focus Groups;Funding;Gender;Generations;Health;Health Resources;HIV;Household;Household and Family;Human Resources;improved;informant;innovation;Interdisciplinary Study;intergenerational;Intervention;Interview;Labor Migrations;late life;Leadership;Life;Life Cycle Stages;Link;Living Arrangement;longitudinal analysis;Longitudinal Studies;member;Methods;Modeling;mortality;multiple chronic conditions;older adult;Older Population;Outcome;Parents;Pensions;Personal Satisfaction;Persons;Population;pro-aging;programs;Province;randomized trial;Research;Resources;Respondent;response;Rural;rural South Africa;Sampling;satisfaction;Services;Shapes;Site;social capital;social determinants;Social isolation;Social support;South Africa;Spouses;Structure;success;Support System;Testing;therapy design;therapy development;trial design;Unemployment;United States National Institutes of Health;Viral;young adult;Youth

PROJECT_TITLE: Intergenerational Intervention: Employing Youth to Promote Aging Healthy with HIV in Rural South Africa

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The best approach to measure blood pressure is unclear. This study will compare 3 approaches for measuring blood pressure including 3 visits to a medical office setting, over 24 hours with a device that automatically measures blood pressure every 30 minutes, and one week of the self-measurement of blood pressure.

PI_NAMEs: REYNOLDS, KRISTI ;SHIMBO, DAICHI  (contact)

PROGRAM_OFFICER_NAME: EINHORN, PAULA T

PROJECT_TERMS: Adult;Age;age difference;age group;Albumins;Ambulatory Blood Pressure Monitoring;Anti-Hypertensive Agents;Asian;awake;biomarker validation;Black race;Blood Pressure;blood pressure control;Blood Pressure Monitors;Cardiovascular Diseases;Creatinine;Data;Detection;Devices;Diagnosis;Diastolic blood pressure;disability-adjusted life years;Echocardiography;Enrollment;Ethnic Origin;Ethnic Population;Guidelines;Health;Hispanic;Home Blood Pressure Monitoring;Hour;Hypertension;hypertension control;hypertensive;improved;indexing;Individual;Left Ventricular Mass;Los Angeles;Measurement;Measures;Medical;Methods;Minority;modifiable risk;New York;Not Hispanic or Latino;Office Visits;older adult;Organ;Outcome;Participant;Pharmaceutical Preparations;primary outcome;Public Health;Race;Randomized;Recommendation;Reference Standards;Reporting;Reproducibility;Research Design;Risk Factors;Sampling;screening;secondary outcome;sex;Site;Testing;urinary;Visit;Woman;years of life lost;young adult

PROJECT_TITLE: Improving the Detection of Hypertension and its Control

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Aging;Genetics;Nutrition

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Imbalances in lipid homeostasis can deleteriously impact health and therefore cells within the organism tightly regulate absorption, synthesis and metabolism to accommodate energetic demands and ensure energetic reserves later in life. My laboratory has identified the mechanism by which cells sense intracellular lipid depletion and respond to metabolic demand by increasing nutrient absorption. This mechanism links the cytosolic sequestration of the nuclear hormone receptor, NHR-49, with nutrient absorption through small G protein signaling and endosomal vesicular transport.

PI_NAMEs: DOUGLAS, PETER MAHAN (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: absorption;Age;AGFG1 gene;Aging;Alleles;Amino Acids;Apical;Binding;Biological Assay;Caenorhabditis elegans;Cell Nucleus;Cell surface;Cells;Cessation of life;Complement;Data;Defect;Endosomes;Ensure;Enzymes;Event;Expenditure;experimental study;Genetic Transcription;geranylgeranyl pyrophosphate;geranylgeranylation;Goals;GTP-Binding Proteins;Hand;Health;Homeostasis;Investigation;isoprenoid;Laboratories;Life;Ligands;Link;lipid biosynthesis;Lipids;Lipolysis;Liposomes;Malabsorption Syndromes;Maps;Metabolic;Metabolism;mevalonate;Modeling;Molecular;Monitor;Monomeric GTP-Binding Proteins;Mutagenesis;mutant;Mutation;Nature;novel;Nuclear;Nuclear Hormone Receptors;Nuclear Receptors;Nutrient;nutrient absorption;Nutrient Depletion;Nutritional Requirements;Organism;oxidation;paralogous gene;particle;Pathway interactions;Phenotype;Physiological;Physiology;Play;prenol;prenylation;prevent;Process;protein degradation;Protein Geranylgeranylation;protein geranylgeranyltransferase;Recycling;Regulation;Research;Residencies;Resistance;Resources;response;Role;screening;Signal Transduction;Signaling Protein;Starvation;Stress;Supplementation;Testing;Time;Transcriptional Activation;Transferase;Variant;Vesicle;vesicle transport;Work

PROJECT_TITLE: Lipid sensing through G protein geranylgeranylation

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Hematology;Infectious Diseases;Prevention

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Deteriorating health condition is the common cause of hospital admissions in patients with COVID-19. Development of blood clots in the blood vessels is a primary cause of death in these patients. We will investigate whether an exacerbated body's response to the SARS-CoV-2 infection is the major cause of clots and poor health outcome in hospitalized patients with COVID-19.

PI_NAMEs: DAYAL, SANJANA  (contact);LENTZ, STEVEN R

PROJECT_TERMS: 2019-nCoV;ACE2;Acute;Biological Markers;Blood;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Blood Vessels;Cause of Death;Cells;Clinical;Coagulation Process;cohort;COVID-19;COVID-19 complications;COVID-19 impact;COVID-19 patient;cytokine;cytokine release syndrome;Data;Deterioration;Development;Dose;druggable target;Endothelial Cells;Enoxaparin;Experimental Models;extracellular;Fibrin fragment D;Future;Galactose;Galactose Binding Lectin;Galectin 3;Generations;Health;Hematopoietic;Histone H3;Histones;Hospitalization;Human;IL6 gene;in vivo;Infection;Inflammation;Inflammatory;Infusion procedures;Interleukin-1 beta;Iowa;K-18 conjugate;Lectin;Link;Literature;Measures;Mediating;Mediator;microvesicles;mouse model;Multiple Organ Failure;Mus;neutrophil;Neutrophil Activation;NF-kappa B;novel;novel coronavirus;Outcome;Pathway interactions;Patients;Phase;Plasma;Platelet Activation;poor health outcome;pre-clinical;Pre-Clinical Model;Predisposition;prevent;Preventive;prophylactic;Proteins;randomized, clinical trials;Randomized, Controlled Trials;receptor;Recovery;recruit;Reporting;Research;Research Design;Resources;response;Role;Sampling;SARS-CoV-2 infection;Severe Acute Respiratory Syndrome;Signal Transduction;therapeutic target;Thrombin;thrombogenesis;Thrombosis;thrombotic;thrombotic complications;TNF gene;Transgenic Mice;translational approach;trial comparing;Universities;Venous Thrombosis;Virus Diseases

PROJECT_TITLE: Cellular effects of SARS-CoV-2 in mediating thrombotic susceptibility

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Mental Health;Neurosciences;Pediatric

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

PHR: PROJECT NARRATIVE Understanding developmental changes in the brain’s functional architecture during childhood and adolescence is a major public health challenge, as adolescence encompasses a critical developmental period during which many mental health disorders emerge. This project aims to construct and validate the first ever functional reference brain atlas for typically-developing youth aged 8 to 17 years old (Dev-Atlas) and to demonstrate its value in predicting neuropsychiatric traits in this age window.

PI_NAMEs: DOUCET, GAELLE EVE (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: 17 year old;Adolescence;Adolescent;Adolescent Development;Adult;Age;age effect;age group;age related;age related changes;aged;Architecture;Atlases;boys;Brain;Brain Mapping;Childhood;Cognitive;cognitive ability;cohort;Communities;connectome;critical developmental period;critical period;Data;Data Set;Development;early adolescence;Event;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Genetic;girls;Hospitals;Human;Image;improved;Incidence;Individual;lens;life span;Link;Literature;Maps;Measures;Mental disorders;Mental Health;Mind;National Institute of Mental Health;network architecture;network dysfunction;neural;Neurocognition;neuroimaging;neuropsychiatry;Outcome;Participant;Phase;Phase Transition;Philadelphia;Psychopathology;Puberty;Public Health;Reproducibility;Research;Rest;Risk;Sampling;sex;Sex Differences;Site;Testing;trait;transition to adulthood;Validity and Reliability;Work;Youth

PROJECT_TITLE: A new reference atlas of brain networks to investigate neuropsychiatric traits in adolescents

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pain Research;Patient Safety;Prevention

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The proposed research is relevant to public health because it can result in enhanced critical care workflow and early critical care intervention, ultimately improving patient outcomes and decreasing hospitalization costs. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to advancing disease diagnosis through medical applications of new tools and technologies, as the proposed research applies advanced computational methods and sensing technologies to automatically quantify and convey patient status in real-time.

PI_NAMEs: BIHORAC, AZRA ;RASHIDI, PARISA  (contact)

PROGRAM_OFFICER_NAME: SHABESTARI, BEHROUZ

PROJECT_TERMS: advanced disease;Algorithms;Artificial Intelligence enhanced;Artificial Intelligence platform;Assessment tool;Caring;Clinical;Clinical assessments;clinical care;Clinical Data;clinical decision-making;Clinical Informatics;clinical practice;clinical predictors;Collaborations;Color;Communication;Complex;Computing Methodologies;cost;Critical Care;Critical Illness;Cues;Data;Data Set;data sharing;Decision Making;deep learning;deep learning algorithm;deep learning model;Deterioration;disease diagnosis;Early Diagnosis;Early Intervention;Electronic Health Record;emotional distress;Environment;Evaluation;Facial Expression;Fostering;Foundations;Frequencies;Goals;Health Personnel;Hospital Costs;Human;Image;improved;indexing;innovation;Intelligence;Intensive Care Units;Intervention;Judgment;Literature;Manuals;Measurement;Medical;Medicine;Mission;Modeling;Monitor;novel;Nurses;Outcome;Pain;Pain Measurement;Patient Admission;Patient-Focused Outcomes;Patients;Physical Function;Physicians;Physiological;Posture;prediction algorithm;predictive tools;Process;Process Assessment;prospective;prospective test;Public Health;Reproducibility;Research;Risk Assessment;risk perception;Sampling;satisfaction;sensor;sensor technology;System;Technology;Testing;Time;tool;training data;United States;United States National Institutes of Health;vigilance;Visual

PROJECT_TITLE: Intelligent Intensive Care Unit (I2CU): Pervasive Sensing and Artificial Intelligence for Augmented Clinical Decision-making

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy

PHR: PROJECT NARRATIVE Although T cells specific for tumor antigens have been a primary target of immunotherapies, tumor-nonspecific “bystander” T cells are often found in human solid tumors. Despite being a major component of the tumor infiltrate, little is known concerning the role of bystander T cells within solid tumors. This project seeks to define mechanisms that underlie bystander entry and function within solid tumors and leverage bystander T cells to enhance anti-tumor immune responses.

PI_NAMEs: MAURICE, NICHOLAS JOSEPH (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 3-Dimensional;Ablation;Activities of Daily Living;Adaptive Immune System;Adoptive Transfer;Age;Anatomy;Animal Model;anti-tumor immune response;Antigen Presentation;antigen-specific T cells;Antigens;Antitumor Response;Autoimmunity;Blocking Antibodies;Bystander Effect;cancer immunotherapy;cancer infiltrating T cells;Cancer Model;cancer therapy;Cause of Death;CD8-Positive T-Lymphocytes;cell motility;Cell Surface Proteins;Cells;Cessation of life;chemokine receptor;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;chronic infection;Color;Complement;congenic;conventional therapy;CTLA4 gene;CXCR3 gene;cytokine;Cytolysis;cytotoxic;design;Diagnosis;Disease;engineered T cells;Excision;exhaustion;experimental study;Failure;Flow Cytometry;Functional disorder;genetically modified cells;Goals;Homeostasis;Human;Immune;immune checkpoint blockade;Immune response;Immune system;Immune Targeting;Immunofluorescence Immunologic;Immunotherapy;Impairment;improved;Infiltration;Inflammation;inhibitor;Interferon Type II;Intervention;Knock-out;Lead;Ligation;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Methods;migration;Mission;Modality;mortality;mouse model;Natural Killer Cells;neoplasm immunotherapy;neoplastic cell;Outcome;Outcomes Research;Pathogenesis;Patients;Phase;Phenotype;Play;Population;Positioning Attribute;Process;programmed cell death protein 1;Proteins;Radiation;receptor;receptor binding;Receptor Signaling;recruit;Relapse;Research;response;Role;Second Primary Cancers;side effect;Solid Neoplasm;Specificity;standard of care;Stress;success;Surveys;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Tissues;tool;Toxic effect;Transgenic Organisms;Transplantation;tumor;Tumor Antigens;tumor heterogeneity;tumor microenvironment;Tumor Promotion;tumor specificity;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health;Up-Regulation;Work

PROJECT_TITLE: Profiling and leveraging bystander T cells within the tumor microenvironment


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Long-term human exposure to chromate compounds is known to induce lung cancer. This proposed study will identify new mechanism of chromium in inducing METTL3 upregulation to trigger tumor growth and angiogenesis. The results will be important to understand new mechanism of chromium for inducing cancer and for finding new biomarker(s) for detecting chromium exposure and cancer prevention in the future.

PI_NAMEs: MCMAHON, STEVEN B. (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Adenosine;angiogenesis;Animal Model;Biological Assay;Biological Markers;biomarker identification;Blood;Blood specimen;cancer prevention;cancer type;carcinogenesis;Cell Proliferation;cell transformation;Cells;chemokine;Chromates;Chromium;chromium hexavalent ion;Chronic;CRISPR/Cas technology;CXCL5 gene;Development;disorder prevention;Dose;early detection biomarkers;Endothelial Cells;Environmental Carcinogens;Enzyme-Linked Immunosorbent Assay;Enzymes;epidemiology study;Epithelial Cells;exposed human population;Exposure to;Future;Gene Chips;Goals;human subject;Hypoxia Inducible Factor;hypoxia inducible factor 1;IL8 gene;IL8RA gene;interest;Interleukin 8A Receptor;Knock-out;Lung;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Messenger RNA;Metal exposure;Methylation;Methyltransferase;Modeling;Modification;Molecular;Mononuclear;Mus;non-smoking;novel;Occupational Exposure;overexpression;paracrine;Peripheral Blood Mononuclear Cell;Play;posttranscriptional;receptor;RNA;RNA Interference;Role;Sampling;Signal Pathway;Signal Transduction;SOX4 gene;Structure of parenchyma of lung;Techniques;Testing;Tissue Sample;transcription factor;Tube;tumor;Tumor Angiogenesis;tumor growth;tumorigenesis;Up-Regulation;Vascular Endothelial Cell;whole genome

PROJECT_TITLE: METTL3 in chromium-induced angiogenesis and carcinogenesis

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Lung;Pediatric

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE The new Emory Pediatrics and Pathology Stimulating Access to Research in Residency (Emory-PP StARR) research training program will enhance core research competencies and mentored research training opportunities for resident physicians with the overarching goal of equipping and retaining the next generation of diverse clinician-scientists to pursue careers in biomedical research focused on heart, lung, and blood health.

PI_NAMEs: CHAHROUDI, ANN M (contact);ROBACK, JOHN D

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Acceleration;Address;Anatomy;Attention;Award;Biomedical Research;Blood;Board Certification;career;career development;career preparation;Child health care;Childhood;Clinical;Clinical Pathology;clinical training;cohort;Communities;Competence;Dedications;Degree program;design;Development;Discipline;Doctor of Philosophy;Educational Curriculum;Educational workshop;Eligibility Determination;Environment;experience;Extramural Activities;Faculty;flexibility;Fostering;Foundations;fundamental research;Funding;Goals;graduate medical education;Grant;Health;Heart;Heart Research;Immune system;implicit bias;improved;Infrastructure;Institution;Interdisciplinary Study;interest;K-Series Research Career Programs;Laboratories;Leadership;learning engagement;learning strategy;Lung;Lung Diseases;Manuscripts;Medical;Medical center;Medical Research;medical schools;Medicine;Mentors;Mentorship;Mission;Monitor;National Heart, Lung, and Blood Institute;next generation;novel strategies;Pathology;pediatric department;Pediatric Research;Pediatrics;Peer Review;Personal Satisfaction;physician-scientist training program;Physicians;Positioning Attribute;programs;Qualifying;recruit;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Training;Residencies;Resources;Respiratory Disease;responsible research conduct;Scientist;Southeastern United States;Strategic vision;Structure;success;systems research;Talents;Training;training opportunity;Training Programs;United States;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Emory Pediatrics and Pathology Stimulating Access to Research in Residency (Emory-PP StARR).


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Hematology;Orphan Drug;Rare Diseases;Regenerative Medicine;Transplantation

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Implanted, encapsulated cell therapies represent a promising approach to continuous, long-term treatment of chronic conditions, but are frustrated by several key challenges that include the foreign body response of the host, local hypoxia in the cell microenvironment and lack of continuous control over cell function. Here we will develop biocompatible cell-encapsulating implants with engineered cell lines and advanced bioelectronics to support and modulate cell function in vivo as a long-term therapy for hemophilia. If successful, the resulting technologies will offer qualitative improvements into the standard of care for chronic diseases.

PI_NAMEs: ANDERSON, DANIEL G (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: Address;Allogenic;American;Animal Model;Beta Cell;betacell therapy;Biocompatible Materials;bioelectronics;Biological;biomaterial compatibility;Biomedical Engineering;Biotechnology;capsule;Cell Line;Cell Physiology;Cell secretion;Cell Survival;Cell Therapy;Cell Transplantation;Cells;cellular engineering;Cellular Structures;China;Chronic;Chronic Disease;Clinical;clinical translation;density;design;Development;Device Designs;Devices;Diabetes Mellitus;Disease;disease model;Dose;Drug Delivery Systems;Drug Modulation;Drug Targeting;Economics;Electronics;Elements;Emerging Technologies;Encapsulated;Engineering;Ensure;epigenetic silencing;Factor VIII;Fibrosis;flexibility;Foreign Bodies;Foreign-Body Reaction;Frustration;Gases;Gene Activation;Generations;Genetic;Glucose;Graft Survival;Hemophilia A;Human;Human Engineering;Hybrid Cells;Hypoxia;Immune;immune function;Immune response;Immune system;immunogenic;Immunosuppression;Implant;implantable device;implantation;improved;In Situ;in vivo;Inflammation;islet;Light;Liver diseases;Maintenance;Medicine;Membrane;Microcapsules drug delivery system;Microfabrication;Modeling;Modification;Monitor;mouse model;Mus;Nature;nonhuman primate;novel;Nutrient;Optics;optogenetics;Oxygen;oxygen transport;Permeability;Pharmaceutical Preparations;Population;Porosity;Pre-Clinical Model;Preclinical Testing;prevent;Production;Property;Protein Secretion;protein transport;Proteins;Protons;response;Risk;Rodent;Scientific Advances and Accomplishments;Silicones;solid state;Source;stable cell line;standard of care;surface coating;Techniques;Technology;technology development;Testing;Therapeutic;therapeutic protein;Time;transgene expression;Transplantation;wireless;Work;Xenograft procedure

PROJECT_TITLE: SMART BIOELECTRONIC IMPLANTS FOR CONTROLLED DELIVERY OF THERAPEUTIC PROTEINS IN VIVO AND ITS APPLICATION IN LONG-TERM TREATMENT OF HEMOPHILIA A

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The application is aimed to support Dr. Stéphanie Gaillard’s efforts at the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center (SKCCC) to enhance processes for NCI Experimental Therapeutics Clinical Trials Network (ETCTN)- and NCI National Clinical Trials Network (NCTN)-led biomarker-selective clinical trials. The supported projects will (i) improve process of patient identification and determination of patient eligibility at the Center level, (ii) facilitate timely referrals to biomarker-selective trials using an electronic medical record clinical trials alert for eligible patients at the Physician level, and (iii) provide study-eligible patients with timely education on the role of biomarkers in treatment decision making (Patient level). Dr. Gaillard serves an indispensable role within the SKCCC to lead the proposed projects.

PI_NAMEs: GAILLARD, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: TAWAB-AMIRI, ABDUL

PROJECT_TERMS: Address;Biological Markers;cancer care;Cancer Center;Caring;clinical trial enrollment;Clinical Trials;Clinical Trials Network;Comprehensive Cancer Center;Computerized Medical Record;Decision Making;Development;Education;Eligibility Determination;Ensure;Equity;Goals;Investigational Therapies;Lead;Minority Groups;Molecular;National Clinical Trials Network;participant enrollment;Patient-Focused Outcomes;Patients;personalized medicine;Physicians;Play;Process;process improvement;programs;Registries;Research;Role;Specialist;targeted treatment;Testing;Underserved Population;uptake;Work

PROJECT_TITLE: Overcoming Challenges Posed by Biomarker-Selective Clinical Trials: The Role of a Research Specialist


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Bipolar Disorder;Brain Disorders;Clinical Research;Depression;Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE Bipolar disorder is a devastating illness - its burden exceeds $202 billion a year in direct treatment, societal and family costs. With no known cure and limited therapeutic options, 50% of patients attempt suicide at least once and the disease is poorly understood; our ENIGMA Bipolar Initiative offers a new, cost-effective, innovative global approach - a new source of power to unblock this logjam - by merging resources, imaging and genomic data, capital infrastructure and talents of leading BD centers from 15 countries across the world.

PI_NAMEs: ANDREASSEN, OLE A;THOMPSON, PAUL M (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Affect;Age;Age of Onset;anti-depressive agents;associated symptom;Attention;Australia;Bayesian Method;Behavioral;biomarker validation;biotypes;Bipolar Disorder;Bipolar I;Brain;Brain imaging;Brain region;Brazil;Canada;Capital;Categories;Chronic;Clinical;clinical imaging;cohort;Collection;comorbidity;comparison control;Complex;Corpus Callosum;cost;cost effective;Country;crowdsourcing;Data;Data Collection;Data Element;data harmonization;data-driven model;demographics;depressive symptoms;design;Diagnosis;Diagnostic;Diffuse;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;disorder subtype;Dose;emotion dysregulation;Emotions;Ethnic Origin;Evaluation;Family;First Degree Relative;follow-up;France;Functional disorder;Functional impairment;Functional Magnetic Resonance Imaging;functional outcomes;General Population;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic variant;genomic biomarker;genomic data;Genomics;Germany;Image;imaging biomarker;imaging detection;imaging study;Impairment;improved;Individual;Infrastructure;innovation;International;Investigation;Japan;Letters;Life;Life Expectancy;life span;Link;Major Depressive Disorder;Manic;Maps;Measures;Mental Depression;Modeling;Monitor;Moods;multimodality;Netherlands;Neurobiology;neuroimaging;Neurosciences;New York;Norway;Obesity;Outcome;outcome prediction;patient subsets;Patients;Pattern;Personal Satisfaction;Pharmaceutical Preparations;Phenotype;polygenic risk score;Power Sources;Predictive Value;Prefrontal Cortex;Productivity;Prognosis;Protocols documentation;psychosocial;Recovery;Reporting;Reproducibility;Research;Research Domain Criteria;resilience;Resources;Rest;Rewards;Risk;Sampling;Scanning;Severities;Site;Sleep disturbances;social relationships;South Africa;Standardization;Structure;Suicide attempt;suicide rate;Susceptibility Gene;Symptoms;System;Talents;Testing;Therapeutic;Thick;tool;treatment effect;treatment response;white matter;women versus men;Work;working group

PROJECT_TITLE: ENIGMA Bipolar Initiative: A Global Study of Imaging Genomics & Clinical Outcomes

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Lung;Neurosciences;Patient Safety;Pediatric;Prevention;Sleep Research

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE Over half a million children undergo removal of tonsils and adenoids (‘adenotonsillectomy’ or AT) every year, primarily for the treatment of sleep disordered breathing (SDB). Two serious issues impact AT candidacy assessments in children, which include the lack of (i) mechanistic understanding of how AT impacts SDB outcomes, (ii) and objective indicators for the magnitude of benefit from AT. By addressing these gaps using a novel biomarker of brain activation, we aim to reduce unnecessary surgeries, increase objectivity, improve disparities, and aid shared decision making related to the most common surgery performed in children under 15 years of age.

PI_NAMEs: ISAIAH, AMAL  (contact)

PROGRAM_OFFICER_NAME: ALFINI, ALFONSO JOSEPH

PROJECT_TERMS: 15 year old;Address;Adenoidal structure;Adverse effects;Adverse event;adverse outcome;Affect;aged;Algorithms;Attention;Behavior;behavior measurement;Brain;Brain region;Caregivers;Characteristics;Child;Child Behavior;Childhood;Clinical;clinical practice;Cognition;Cognitive;cost effective;Coupled;Data Science;Disease;Disparity;Drowsiness;Enrollment;Equipment and supply inventories;Excision;executive function;experience;Exposure to;follow up assessment;Friends;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;General Anesthesia;Guidelines;Harm Reduction;health care service utilization;Impairment;improved;Impulsivity;interdisciplinary approach;Knowledge;Learning Disorders;Measures;Mediating;Medical;model development;Modeling;multidisciplinary;neural;novel marker;Observational Study;Obstructive Sleep Apnea;Operative Surgical Procedures;Outcome;outcome prediction;Parents;Patient observation;Patient Selection;Patients;Pediatric Surgical Procedures;Performance;Polysomnography;Population Heterogeneity;predictive modeling;Prefrontal Cortex;primary outcome;Problem behavior;Quality of life;Questionnaires;Race;Reporting;Resolution;response;Risk Reduction;satisfaction;screening;secondary outcome;Severities;shared decision making;Sleep;Sleep Apnea Syndromes;Sleep disturbances;Snoring;Societies;Socioeconomic Status;specific biomarkers;Stratification;Structure;Supportive care;Symptom Burden;Symptoms;Techniques;Testing;Tonsil;treatment group;Treatment outcome;United States;United States National Institutes of Health;Unnecessary Surgery

PROJECT_TITLE: A mechanistic understanding of treatment-related outcomes of sleep disordered breathing using functional near infrared spectroscopy

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Therapeutics and Interventions;Data Science;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The proposed project is making use of computers to analyze data from hospitalized patients with respiratory disease including COVID-19. We want to develop methods to identify patterns in the patient data which predict who is at risk for respiratory failure and may need mechanical ventilation. We have a very strong team of doctors and researchers who work closely together, covering all aspects of the proposed research, which we hope will help us improve the care of critically ill patients in hospitals.

PI_NAMEs: MALHOTRA, ATUL ;NEMATI, SHAMIM  (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: acute hypoxemic respiratory failure;Address;Adoption;Algorithms;Area;Awareness;Black Box;Caregivers;Caring;Clinical;clinical care;Clinical Data;clinical decision support;clinical predictors;Computers;Confidence Intervals;COVID-19;COVID-19 pandemic;COVID-19 patient;Critical Care;Critical Illness;Data;data integration;Data Set;data streams;deep learning;deep learning algorithm;deep learning model;design;Deterioration;Economics;Electronic Health Record;empowerment;Equipment;health care delivery;Health Personnel;Healthcare Systems;Hospitalization;Hospitals;Hour;Human Resources;Image;Impairment;implementation barriers;improved;innovation;Institution;Intensive Care Units;Intervention;Intratracheal Intubation;Intubation;Judgment;Laboratories;machine learning algorithm;Measures;Mechanical ventilation;Mechanical Ventilators;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;multimodal data;multimodality;novel;Observational Study;Organ;pandemic disease;Patient Care;Patients;Pattern;Pharmaceutical Preparations;portability;prediction algorithm;predictive modeling;Prognosis;prospective test;Provider;Publishing;Reporting;Research;Research Personnel;Resource Allocation;Resources;Respiratory Disease;Respiratory Failure;Risk;Risk Estimate;risk prediction model;Running;serial imaging;skills;support tools;supportive environment;System;Techniques;Technology;Testing;Therapeutic Intervention;Thoracic Radiography;Time;Triage;Ventilator;Work

PROJECT_TITLE: VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: Nashville

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Our research elucidates the neural mechanisms underlying flexible decision making in environments with real- world complexity. Our projects document how nonhuman primate subjects cope with real world complexity by combining the use of working memory, adaptive regulation of exploration and attentional prioritization to relevant environmental dimensions. Our projects will identify which brain areas in the frontal – striatal network realize these subcomponent processes and how specific inhibitory cell classes in these brain areas support flexible decision making in the primate brain.

PI_NAMEs: WOMELSDORF, THILO  (contact)

PROJECT_TERMS: Address;Animals;Anterior;Area;Attention;attentional bias;Behavioral;Behavioral Model;Brain;Brain region;cell type;Cells;Cephalic;cingulate cortex;Classification;Code;Cognitive;cognitive change;Complex;coping;Corpus striatum structure;Data;Decision Making;Dimensions;Dorsal;Electrophysiology (science);Environment;expectation;flexibility;Focused Ultrasound;Future;high dimensionality;high reward;Hybrids;Interneurons;Intervention;Learning;learning strategy;Lesion;Mediating;Modeling;Monkeys;neural;neural circuit;neuromechanism;Neurons;nonhuman primate;Outcome;Performance;Population;Prefrontal Cortex;Primates;Probability;Process;Protocols documentation;Psychological reinforcement;recruit;Regulation;Research;Rewards;Role;Short-Term Memory;Speed;System;Testing;tool;Uncertainty;Update;Visual

PROJECT_TITLE: Neural Mechanisms of Learning Relevance in Multidimensional Environments


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: In this project we will assess how temperature impacts selective and stochastic alterations to WNV populations during systemic mosquito infection. We also will explore how virus particle aggregates and infection of individual cells by multiple WNV genotypes may influence the amount and type of genetic diversity that is maintained in the virus population. This project leverages over 15 years’ worth of WNV and ZIKV research and makes innovative use of new molecular tools that we have developed as part of this project.

PI_NAMEs: EBEL, GREGORY DAVID (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 2019-nCoV;Address;Affect;Alpha Virus;Antibodies;Arboviruses;arthropod-borne;Bar Codes;Biology;Biometry;Birds;Cells;Chikungunya virus;Competence;Complement;computerized tools;Culex (Genus);Culicidae;Data;Disease;Disease Outbreaks;Ecology;Environment;environmental change;Evolution;Face;fitness;Flaviviridae;Flavivirus;Flavivirus Infections;Flow Cytometry;Funding;Future;Genetic Variation;Genome;Genotype;Geography;global temperature;Goals;Health;Human;Humanities;Incubated;Individual;Infection;innovation;Insecticide Resistance;Knowledge;land use;Literature;Maintenance;Medicine;Methodology;Midgut;Molecular;Molecular Biology;multidisciplinary;mutant;Natural Selections;Nature;novel;Nucleotides;Outcome;Phase;Population;Population Biology;Population Genetics;Population Heterogeneity;prevent;Public Health;Research;RNA Sequences;RNA Viruses;Role;Salivary Glands;Shapes;System;Temperature;Testing;theories;Time;Tissues;Togaviridae;tool;transmission process;Urbanization;Vaccines;Variant;vector;vector competence;vector mosquito;Vertebrates;viral fitness;Viremia;Virion;virology;Virus;West Nile virus;Work;Zika Virus

PROJECT_TITLE: Quasispecies dynamics in arbovirus persistence emergence and fitness

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE Malaria vaccines capable of completely preventing infection by Plasmodium, the parasite which causes malaria, in non-endemic regions have not shown the same high-level protection when tested in endemic regions. While it is well known that active or prior Plasmodium exposure impacts the immune system in endemic regions, a comprehensive assessment of how these conditions affect vaccination or how even to measure this effect are lacking due to the inability to access critical sites of the immune system such as the liver and bone marrow. Here, we will overcome this by using two non-human primate models that mimic malaria disease in humans and permit comprehensive tissue sampling, and integrate these with human clinical trial samples to build a more complete understanding of how previous malaria exposure impacts vaccine performance and strategies to build the first protective malaria vaccine.

PI_NAMEs: MURPHY, SEAN C;WILDER, BRANDON KEITH (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acute;acute infection;adaptive immune response;adaptive immunity;Address;Affect;Africa South of the Sahara;Age;animal data;Animal Model;Animals;Area;base;Biological Markers;Blood;Blood specimen;Bone Marrow;CD8-Positive T-Lymphocytes;Cells;Chronic;chronic infection;circumsporozoite protein;Clinical;clinical trial participant;Clinical Trials;Complex;Data;density;design;Disease;disorder control;efficacy trial;Erythrocytes;Europe;Exhibits;experience;exposed human population;Goals;Human;human data;Immune;Immune Evasion;Immune response;Immune system;Immunity;Immunization;immunogenicity;Immunologic Markers;Immunological Models;Immunologics;Immunology;immunoregulation;Immunosuppression;Incidence;Individual;Infection;Infection prevention;Inflammation;Inflammatory;Innate Immune Response;insight;inter-institutional;Laboratories;Liver;Macaca mulatta;Macaca nemestrina;Malaria;malaria infection;Malaria Vaccines;Maps;Measures;model building;Modeling;mouse model;Natural Immunity;nonhuman primate;novel;Parasitemia;Parasites;Pattern;Performance;Peripheral;peripheral blood;Persons;Plasmodium;Primates;Publishing;Resources;response;Sampling;Scientist;Site;Sporozoites;Symptoms;T-Lymphocyte;Testing;tissue resident memory T cell;Tissue Sample;Tissues;transmission process;Vaccinated;Vaccination;vaccine candidate;vaccine efficacy;vaccine trial;Vaccines;volunteer

PROJECT_TITLE: Integrating human and non-human primate data to understand the acquisition of pre-erythrocytic immunity in the face of previous malaria exposure


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: OMAHA

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: Narrative Sudden unexpected death in epilepsy (SUDEP) is a significant cause of epilepsy related mortality with an especially high rate (1 in 150) in patients who are refractory to current pharmacotherapies. It is unknown why patients fail to autoresuscitate (or recover) and ultimately die of SUDEP. Here, we will determine the mechanisms that contribute to autoresuscitation failure in a preclinical model of SUDEP.

PI_NAMEs: SIMEONE, KRISTINA A;SIMEONE, TIMOTHY A. (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acute;Air;Animal Model;antagonist;Anticonvulsants;Apnea;Area;Blood gas;Breathing;clinically relevant;Data;Deterioration;Disease;Epilepsy;Event;Exhibits;experience;Failure;Goals;Hypercapnia;hypocretin;Hypothalamic structure;Hypoxia;Impairment;in vivo;Individual;Intractable Epilepsy;Knockout Mice;Lateral;Life;locus ceruleus structure;Longevity;Maintenance;Metabolic;Molecular Target;mortality;Motor Seizures;mouse model;Mus;Nervous System Disorder;Neurons;neuropathology;Neuropeptides;neuroregulation;novel;Patients;Persons;Pharmacotherapy;pre-clinical;Pre-Clinical Model;preBotzinger complex;preclinical study;Predisposition;Probability;programs;Prone Position;Publishing;Qualifying;receptor;Recovery;Recurrence;Refractory;Reporting;Research;respiratory;Respiratory physiology;response;Risk;Risk Assessment;Seizures;Series;sudden unexpected death in epilepsy;support network;Technical Expertise;Testing;Therapeutic

PROJECT_TITLE: Autoresuscitation and SUDEP

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Our goal is to study advanced detector designs and scanner configurations that offer improved performance for Total-Body time-of-flight (TOF) PET and to judge the merits of these choices by their impact on a variety of potential total-body PET clinical/research applications. Our studies will include development of enabling technology for two TOF detector concepts that can be scaled to a full system: one (with LYSO) emphasizing TOF resolution and the other (with BGO) emphasizing higher intrinsic sensitivity. These studies will inform Monte Carlo simulations of scanner models that will be correlated with human studies performed with the PennPET Explorer scanner based on current technology.

PI_NAMEs: KARP, JOEL S (contact);SURTI, SULEMAN

PROGRAM_OFFICER_NAME: ZHANG, YANTIAN

PROJECT_TERMS: analog;Clinical;clinical care;Clinical Research;Complement;cost;Coupled;Data;Data Set;design;detector;Development;Devices;digital;Disease;Electronics;Evaluation;flexibility;Future;Geometry;Goals;Human;human data;Image;image reconstruction;improved;instrument;instrumentation;Investigation;Length;Lesion;Light;Malignant Neoplasms;Measurement;Methodology;Methods;Modeling;Modernization;Monte Carlo Method;Noise;novel strategies;Outcome;Performance;Positron-Emission Tomography;radiotracer;Recovery;Research;research study;Resolution;response;Sampling;signal processing;Signal Transduction;simulation;Site;standard of care;statistics;success;System;Technology;temporal measurement;Testing;Time;whole body imaging;Work

PROJECT_TITLE: Time-of-Flight PET for Improved Whole-Body Imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Inflammatory Bowel Disease;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: The robotic platform we propose has the potential to provide a safer, more accessible, and potentially painless alternative to standard colonoscopy for patients with Inflammatory Bowel Disease (Ulcerative Colitis or Crohn's disease)-a disease that impacts the lives of over three million Americans, who are at a 6-fold increased risk for post-colonoscopy adverse events when compared to their non-lBD counterparts. The platform uses magnetic actuation, intelligent closed-loop control, and integrated assistive autonomy of our diagnostic and therapeutic magnetic flexible endoscope (MFE) to facilitate intuitive endoscopist-directed motion under precise control with a novel colon-visualization-index (CVI) that provides feedback to the endoscopist with estimates of the portion of colon lumen successfully imaged to maximize the yield of exam. We propose the first in-human study of a magnetically actuated robotic platform for colonoscopy and the first in-human demonstration of intelligent control with assistive autonomy using magnetic fields.

PI_NAMEs: OBSTEIN, KEITH L (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: 3-Dimensional;Address;Adverse event;Algorithms;American;Anatomy;Animal Model;arm;Articulation;Artificial Intelligence;aspirate;Automation;Benchmarking;Benign;biomaterial compatibility;Biopsy;Cadaver;capsule;Clinical;clinical application;Collaborations;Collection;Colon;Colonoscopes;Colonoscopy;colorectal cancer risk;comorbidity;Complication;Coupling;Crohn's disease;design;Detection;detection method;Development;Device Designs;Devices;Diagnosis;Diagnostic;Diameter;Disease;Distal;Dysplasia;Electric Wiring;Endoscopes;Endoscopy;Engineering;Excision;experience;Failure;Feedback;first-in-human;flexibility;Frequencies;Funding;Future;gastrointestinal;General Population;Goals;Guidelines;Head;Human;human study;Image;image processing;improved;in vivo;indexing;Inflammatory Bowel Diseases;Injections;innovation;instrument;Insufflation;Intervention;Intubation;Intuition;Irrigation;Learning;Lesion;lifetime risk;magnetic field;Magnetism;Malignant Neoplasms;manufacture;Maps;Measurement;Measures;Mechanics;Medical;Medical Device;Mesentery;Methods;Modeling;Motion;Mucositis;Mucous Membrane;Nature;novel;Nursing Faculty;operation;Pain;Painless;Pathology;Patients;Perforation;Performance;phantom model;Polyps;Populations at Risk;porcine model;Positioning Attribute;prevent;procedure safety;Procedures;Prognosis;Provider;Recommendation;reconstruction;Recording of previous events;Research Personnel;response;Retrieval;Risk;Risk Reduction;robot assistance;robot control;Robotics;safety assessment;Sedation procedure;skills;Software Validation;Stream;Stretching;success;Suction;Surface;Technical Degree;Technical Expertise;Technology;Testing;Therapeutic;Time;tool;Training;Translational Research;trial comparing;Ulcerative Colitis;Validation;Vision;Visualization;Work

PROJECT_TITLE: A magnetic capsule endoscope for colonoscopy in patients with inflammatory bowel disease

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: We study tumor suppressor miR-125b therapeutics for traumatic brain injury (TBI) using the lateral fluid percussion-induced TBI model in young adult rats (10-11 weeks old) of both sexes. This proposal will show that intravenous (i.v.) miR-125b mimic decreases target genes (Mknk2, Alpk3, Neu1, Bap1) in blood (leukocytes, platelets), endothelial cells and brain (neurons, astrocytes, microglia) to improve TBI outcome: miR-125b mimic→ Mknk2↓ Alpk3↓ Neu1↓ Bap1↓ in blood cells, endothelial cells and brain cells → improvement of multiple pathological and behavioral outcomes after TBI. The combined use of intravenous miR-125b mimic and PEG-liposomes to treat TBI is novel and can be translated to treat human TBI, since i.v. route is translatable for human use and the PEG-liposomes used for in vivo miR drug delivery is FDA-approved.

PI_NAMEs: LIU, DAZHI JEFF (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: 3' Untranslated Regions;Acute;Address;Algorithms;Animal Model;Applications Grants;Astrocytes;Attenuated;behavioral outcome;Binding;Binding Sites;Blood;Blood Cells;Blood Platelets;blood-brain barrier disruption;Brain;brain cell;Brain Injuries;Cause of Death;Cell Cycle;Clinical Trials;Cognitive deficits;cognitive function;Data;disability;Dose;Drug Delivery Systems;drug development;Endothelial Cells;Endothelium;Enzymes;Failure;FDA approved;Functional disorder;Genes;genome sequencing;Hippocampus;Human;IL2 gene;Impaired cognition;improved;improved outcome;In Vitro;in vivo;Infiltration;Inflammation;inhibitor;injured;Intravenous;Intraventricular;kinase inhibitor;Lateral;Leucocytic infiltrate;Leukocytes;Liposomes;Liquid substance;Literature;Malignant Neoplasms;MAPK8 gene;Mediating;Microglia;MicroRNAs;Modeling;monocyte;neuron loss;Neurons;neutrophil;novel;Oligonucleotides;Oncogene Activation;Oncogenes;Outcome;Pathologic;Pathway interactions;Percussion;Peripheral;Phosphotransferases;Play;prevent;Proteins;Rattus;Research Personnel;response;Role;roscovitine;Route;sex;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;therapeutic miRNA;Therapeutic Studies;Tissues;Translating;translational potential;Traumatic Brain Injury;Tumor Suppressor Proteins;v-src Oncogenes;whole genome;Work;young adult

PROJECT_TITLE: MicroRNA Therapeutics for Traumatic Brain Injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE The research proposed in this application will lead to greater understanding of how stress and damage related to the immune response is mitigated. Such knowledge is relevant to public health because it will lead to the potential manipulation of this response to the patient’s advantage in the treatment of infections and autoimmune disorders.

PI_NAMEs: GARSIN, DANIELLE A (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Address;Affect;Animals;Anti-Inflammatory Agents;ATP phosphohydrolase;Autoimmune Diseases;Bacterial Infections;biological adaptation to stress;Caenorhabditis elegans;Chemicals;Communicable Diseases;Complex;Cytoplasm;Cytoprotection;Data;Drug Metabolic Detoxication;Endoplasmic Reticulum Degradation Pathway;Ensure;Exposure to;Family;GATA1 gene;Genes;Genetic Transcription;Goals;Human;Immune;Immune response;Infection;Inflammatory Response;innovation;insight;interest;Intestines;Investigation;Knowledge;Laboratories;Lobular Neoplasia;Mammals;member;Membrane;Modeling;NADPH Oxidase;novel;nuclear factor-erythroid 2;Orthologous Gene;Oxidative Stress;pathogen;pathogen exposure;Pathogenicity;Pathology;Pathway interactions;Patients;pharmacologic;prevent;Process;Production;programs;protective effect;Protein Family;Public Health;Publishing;Reactive Oxygen Species;Regulation;Research;Resistance;response;RNA Interference;Role;Side;Stress;Therapeutic;trafficking;transcription factor

PROJECT_TITLE: Response to Immune Associated Stress

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative African Americans with type 2 diabetes is a substantial public health problem. A novel approach to diabetes self- management that capitalizes on the strong family culture among African Americans is proposed with an in-person group of individuals with type 2 diabetes and their family members to be used as a way to promote adherence to diabetes self-management and to facilitate behavior changes and health outcomes among African Americans with type 2 diabetes while improving healthy lifestyle behaviors among family members. This study will contribute to the development of family dyad-focused intervention as an effective approach with long-term goal of improving glycemic control and health-related quality of life for African Americans.

PI_NAMEs: HU, JIE  (contact)

PROGRAM_OFFICER_NAME: RAJAPAKSE, NISHADI

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;Address;Adherence;Adult;African American;African American population;arm;Behavior;behavior change;Behavioral;Behavioral Mechanisms;blood pressure control;Blood Vessels;Calories;Carbohydrates;Clinic;clinical research site;Communication;Communities;comparison intervention;Complications of Diabetes Mellitus;Data;Death Rate;Development;Diabetes Mellitus;diabetes self-management;Dietary intake;Disease Management;Education;Enrollment;Extended Family;Family;Family member;family support;Feedback;follow-up;Foundations;glycemic control;Glycosylated hemoglobin A;Goals;Health;Health behavior and outcomes;health disparity;health related quality of life;Healthcare Systems;Healthy Eating;healthy lifestyle;Hispanic;Hospitalization;Impaired cognition;improved;Individual;Intake;Intervention;Knowledge;Life;Life Style;Low income;macrovascular disease;Measures;middle age;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;novel strategies;Ohio;older adult;Outcome;Participant;participant enrollment;Patient Recruitments;Patients;Pattern;Persons;Pharmacy facility;Phase;Physical activity;Population;post intervention;primary outcome;Problem Solving;Process;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Research Priority;retention rate;Risk Factors;satisfaction;Science;secondary outcome;Self Management;skills;social;Social Environment;Social Processes;Stress;Stress and Coping;Support Groups;Surveys;Telephone;telephone session;Time;treatment arm;treatment as usual;United States National Institutes of Health;Vulnerable Populations;Waiting Lists;Walking;Work

PROJECT_TITLE: A Family-Dyad-focused Diabetes Self-Management Intervention for African American Adults with Type 2 Diabetes

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PUBLIC HEALTH REVELANCE (Narrative) Our bodies tissues are where most pathogens are encountered (SARS-CoV2, influenza, HSV, candida) and where the majority of tumors arise. Immune protection of barrier tissues is required to combat pathogen infection and limit tumor development however, simultaneous regulatory mechanisms prevent adverse auto- inflammation, and autoimmunity at these sites. In this proposed work, we seek to define key regulatory mechanisms that govern this balanced tissue immunity, required for human health.

PI_NAMEs: ANANDASABAPATHY, NIROSHANA  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 2019-nCoV;Adoptive Cell Transfers;Antigen Presentation;Antigens;Apoptotic;ATAC-seq;Autoantigens;Autoimmunity;autoinflammation;Basic Science;Behavior;Biology;Blood;Bone Marrow;cancer cell;Candida;Cell Maturation;cell motility;cell type;Cells;Cellular biology;Chromatin;CISH gene;Clinical;clinically relevant;combat;conditioning;Cues;Data;Dendritic Cells;Development;Disease;drug development;Environment;Equilibrium;Face;Genes;Goals;Health;Homeostasis;Human;IFNG gene;Immune;Immune system;Immune Tolerance;Immunity;immunogenic;improved;in vivo;Individual;Infection;Inflammation;Inflammatory;Influenza;insight;Interferon Type II;Intervention;Knowledge;Licensing;LoxP-flanked allele;Lung;lymphoid organ;Maps;Measures;Melanoma;Modeling;modifiable behavior;Molecular;Molecular Target;Mus;Myelogenous;neuroinflammation;NF-kappa B;Organism;pathogen;Pathogen detection;Pathogenesis;Pathogenicity;Pathway interactions;Pattern;Peptide/MHC Complex;Peripheral;pharmacologic;Population;Positioning Attribute;preservation;prevent;progenitor;programs;Proteins;Psoriasis;Public Health;Publishing;Reporter;response;Self Tolerance;Signal Transduction;Simplexvirus;Site;Skin;source localization;Stimulus;Surveys;Systems Biology;T-Lymphocyte;Testing;Time;Tissue Differentiation;tissue repair;Tissues;Transcript;transcription factor;transcriptome;tumor;Tumor Immunity;Vaccination;vaccination strategy;Vaccines;Viral;viral DNA;Virus;Vitiligo;Work

PROJECT_TITLE: Interrogating unique DC adaptations to tissue to promote barrier immunity and tolerance


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: BRISBANE

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF QUEENSLAND

PHR: PROJECT NARRATIVE This project will develop and apply analytical technology enabling nanoscale characterization of biomolecular condensates (nanoBMCs) in living neurons using data from super-resolution single particle tracking imaging. Current BMC analyses mostly rely on fluorescence recovery after photobleaching (FRAP) on large BMCs which overlooks potential nanoscale BMCs likely to act as “seeds” for the generation of larger BMCs and of irreversible amyloids associated with Alzheimer’s disease (AD). Based on spatiotemporal indexing, our proposed analytical pipeline will enable characterization of the dynamic spatiotemporal nanoscale organization of wildtype and AD- mutant Tau and a-synuclein trapped in these enigmatic membraneless nanoscale compartments.

PI_NAMEs: MEUNIER, FREDERIC ANDRE (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: 3-Dimensional;Actins;Aging;Alcohol consumption;Algorithms;alpha synuclein;Alzheimer's Disease;Amyloid;Astrocytes;Axon;Behavior;Binding;bioinformatics tool;Biology;Cell Physiology;Cells;Cellular biology;Cluster Analysis;Code;Color;Critical Pathways;Data;density;Dependence;Detection;Development;diffraction of light;Diffusion;Disease;Drops;Environment;Evolution;Exhibits;experimental analysis;Fluorescence Recovery After Photobleaching;Generations;Genes;Grant;graphical user interface;Health;Hippocampus;Image;In Vitro;in vivo;indexing;Individual;insight;Label;light microscopy;Liquid substance;Measures;Mediating;Membrane;Methodology;Methods;Molecular;molecular imaging;mutant;Mutation;Names;nanocluster;nanoscale;neglect;Nerve;Neurons;novel;Nucleic Acids;open source;Organelles;Outcome;particle;Periodicals;Phase;Physical condensation;Protein Dynamics;Proteins;Pythons;Recurrence;Research;Resolution;segregation;single molecule;Solid;sound;spatiotemporal;Structure;superresolution imaging;superresolution microscopy;Synapses;synuclein;tau mutation;tau Proteins;Technology;Time;tool;Trees;ultra high resolution;Validation;Video Games

PROJECT_TITLE: Single molecule biomolecular condensate analysis in neurons


NIH_SPENDING_CATS: Autism;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: This project aims to uncover the mechanisms by which the cortex controls its processing. We will use new closed-loop stimulation and laminar recording technology for direct causal manipulation of neural activity and the recording of its consequences. We will test the hypothesis that deep cortical -layer alpha/beta rhythms carry top-down predictions that inhibit the superficial-layer gamma/spiking that feedforward predicted sensory inputs.

PI_NAMEs: MILLER, EARL K (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TITLE: Layer-specific manipulation to test feedforward/feedback cortical circuitry

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]