NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Mental Health;Neurosciences;Pediatric;Prevention;Primary Health Care

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE: Mental disorders are often early-onset chronic diseases, with brain and behavioral risk markers of common internalizing/externalizing problems evident in infancy. To accelerate translation, we will use multi-method imaging, behavioral and data science innovations to generate an infant mental health risk calculator for pragmatic public health use, derived from a clinically enriched “Mental Health Earlier-Synthetic Cohort” of 1,020 infants using established study samples (characterized from birth-54 months). Clinical prediction algorithms will deliver broadly useful tools for earlier prediction and prevention of mental disorder and parameters to inform when imaging methods will be most informative in large-scale neurodevelopmental studies.

PI_NAMEs: LUBY, JOAN L.;ROGERS, CYNTHIA ELISE;WAKSCHLAG, LAUREN S (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: Acceleration;affective neuroscience;Age;Algorithms;Assessment tool;Behavior;Behavioral;Behavioral Sciences;Birth;Brain;Cardiovascular system;Child;Chronic Disease;Clinic;Clinical;clinical diagnostics;clinical predictors;Clinical Research;clinical risk;clinical translation;Cognitive;cognitive neuroscience;cohort;connectome;cost effectiveness;Data;Data Science;Data Sources;deep learning;Development;Diagnostic;Dimensions;Disease;early childhood;Early identification;Early Intervention;early onset;Electroencephalography;Elements;emotion dysregulation;Environmental Risk Factor;epidemiologic data;Epidemiology;Extramural Activities;Future;Generations;Height;imaging modality;imaging science;improved;infancy;Infant;innovation;Interview;life span;Magnetic Resonance Imaging;Measurement;Measures;medical specialties;mental disorder prevention;Mental disorders;Mental Health;Methods;Modeling;multidisciplinary;multimodality;Nervous System Disorder;neural;neural correlate;neurodevelopment;neuroimaging;Neuronal Plasticity;Nursery Schools;Outcome;Pattern;Performance;Phenotype;postnatal;prediction algorithm;predictive tools;Predictive Value;Prevention;Primary Care;primary care setting;Properdin;protective factors;Protocols documentation;Psychopathology;Public Health;Research;Research Domain Criteria;Research Personnel;Resources;Risk;Risk Assessment;Risk Marker;risk prediction;risk prediction model;Sampling Studies;Science;Series;Site;sound;Specific qualifier value;standard of care;Standardization;Survey Methodology;Surveys;Testing;Time;tool;Translations;Uncertainty;Universities;Validation;visual tracking;Washington

PROJECT_TITLE: Optimizing prediction of preschool psychopathology from brain: behavior markers of emotion dysregulation from birth: A computational, developmental cognitive neuroscience approach

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: UNIVERSITY PARK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Unlike adult infections, newborn infections with herpes simplex virus (HSV) can have dire outcomes – with more than half of these infants experiencing viral spread into the brain or other organs. We will use viral comparative genomics, along with phenotypic comparisons in cellular and animal models of infection, to decipher how differences in viral genetics impact the severity of neonatal disease in vivo.

PI_NAMEs: SZPARA, MORIAH  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Adult;Animal Model;Anti-viral Agents;Antibodies;Body Surface;Brain;Categories;Cell model;cell type;Cells;Central Nervous System;Central Nervous System Infections;Cessation of life;Clinical;Clinical Course of Disease;Clinical Data;Clinical Management;comparative genomics;Congenital herpes simplex;Consensus;Data;Data Set;Death Rate;Diagnosis;Dimensions;Disease;Disease Outcome;Dissection;Epithelium;experience;Eye Infections;Foundations;Frequencies;Future;Genetic;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;genomic locus;genomic variation;Genomics;Genotype;Goals;Herpes Simplex Infections;Herpesvirus 1;high risk;High-Throughput Nucleotide Sequencing;Human;Human Herpesvirus 2;Immune Evasion;Immune system;Immunologics;Impairment;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;Individual;Infant;infant infection;Infection;Infectious Skin Diseases;Intervention;Invaded;Lesion;Life;Link;Liver;Location;Lung;Measures;Minor;Morbidity - disease rate;Morphology;mortality;Mothers;mouse model;Neonatal;neonatal infection;neonate;Neurologic;Neurons;neurovirulence;Newborn Infant;Newly Diagnosed;novel;Oral cavity;Organ;Outcome;Passive Immunization;Pathogenesis;Pattern;Phenotype;phenotypic data;Population;predictive modeling;protein expression;protein function;Proteins;Recurrence;response;Risk;risk prediction;Risk Reduction;Sampling;Severities;Simplexvirus;skin disorder;targeted treatment;Therapeutic Intervention;Time;Translating;United States;Variant;Viral;viral genomics;Viral Proteins;Virulence;Virus;virus culture;Virus Diseases;virus genetics;Virus Replication

PROJECT_TITLE: The impact of viral genomic variation on neonatal disease outcomes

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative High blood pressure (hypertension), caused in some cases by genetic mutations such as in Familial Hyperkalemic Hypertension (FHHt), is a great burden to public health both medically and financially. The kidney tubules are the main site in the body that adjusts body salt content, and by doing so, helps to set the blood pressure to an optimal level. The proposed research investigates the molecular mechanism behind a newly discovered genetic mutation that causes FHHt and may lead to the development of new drugs or cost- efficient treatments to target hypertension.

PI_NAMEs: CORNELIUS, RYAN J (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acceleration;American;Area;Award;Binding;Blood Pressure;blood pressure regulation;Catalytic Domain;Cells;Chronic Kidney Failure;Complex;COPS5 gene;cost efficient;Cullin Proteins;cullin-3;Cultured Cells;Data;Development;Disease;disease phenotype;Distal;Distal convoluted renal tubule structure;DNA Sequence Alteration;Environment;Excision;Experimental Designs;Failure;Familial disease;familial hyperkalemic hypertension;Functional disorder;Future;Genetic;Goals;Heart Diseases;Homeostasis;Human;human disease;hyperkalemia;Hypertension;hypertension treatment;Impairment;In Vitro;in vivo;in vivo evaluation;interest;Journals;Kidney;Kidney Diseases;Kidney Failure;kidney fibrosis;Knockout Mice;Lead;Ligase;Lysine;Mediating;Medical;Mendelian disorder;Mentors;Modeling;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Mutation;Nephrology;Nephrons;novel therapeutics;Pathogenesis;Pathway interactions;Pharmacologic Substance;Phenotype;Phosphotransferases;Physiological;Physiology;Play;Positioning Attribute;Potassium;prevent;Prevention;protein degradation;Protein Subunits;Proteins;Public Health;Publishing;Regulation;renal damage;Renal tubule structure;Research;Research Personnel;Risk Factors;Role;Site;skills;Societies;Sodium Chloride;Stroke;success;symporter;Syndrome;Techniques;Testing;thiazide;Type II Pseudohypoaldosteronism;Ubiquitin;ubiquitin ligase;Ubiquitin Like Proteins;ubiquitin-protein ligase;Up-Regulation;Work

PROJECT_TITLE: Role of the COP9 Signalosome (CSN) in kidney disease and hypertension

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Physical Rehabilitation;Prevention;Rehabilitation;Women's Health Research

ORG_CITY: AMHERST

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: This project will provide the first-ever direct measure of muscle mass in a large sample of community dwelling postmenopausal women using the D3-creatine method, a highly accurate and scalable measure of muscle mass that can be carried out remotely (at home). This novel approach will be used to compare the antecedents and consequences of low muscle mass in cancer survivors and age-matched cancer-free controls. This research will contribute to the development of public health recommendations and intervention strategies to prevent low muscle mass and associated adverse health outcomes in older and long-term cancer survivors.

PI_NAMEs: BANACK, HAILEY ROSE (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Acceleration;Activities of Daily Living;Address;Age;age acceleration;age effect;age group;age related;age-related muscle loss;Aging;aging process;anti-cancer research;Big Data;Blood;Breast;cancer invasiveness;Cancer Patient;Cancer Survivor;Cancer Survivorship;cancer therapy;Clinical Research;cohort;Colorectal;Communities;comparison group;Creatine;Data;density;Development;Diagnosis;Dual-Energy X-Ray Absorptiometry;Epidemiology;epidemiology study;Equilibrium;Female;follow-up;functional decline;functional outcomes;Funding;Future;Gait speed;Gynecologic;Health;healthspan;Home;improved;Incidence;innovation;Intervention;Knowledge;lean body mass;Life;Longevity;Lung;Machine Learning;machine learning method;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Melanoma;Metabolic;Methodology;Methods;Mobility disability;Morbidity - disease rate;mortality;Muscle;muscle form;Muscular Atrophy;National Cancer Institute;normal aging;novel;novel strategies;older adult;older women;Outcome;Participant;Pathway interactions;Physical Function;Physical Performance;Physiological;Population;population based;Postmenopause;preclinical study;prediction algorithm;prevent;Prospective, cohort study;Protocols documentation;Public Health;Quality of life;Questionnaires;Recommendation;reduced muscle mass;Research;Research Design;risk prediction model;Sample Size;Sampling;Skeletal Muscle;skeletal muscle wasting;Source;Standardization;Surgical complication;survivorship;Toxic effect;Woman;women's diagnosis;Women's Health;X-Ray Computed Tomography

PROJECT_TITLE: Ms. LILAC: Muscle Mass in the Life and Longevity After Cancer (LILAC) Study

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Schizophrenia;Serious Mental Illness

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Increased inflammation in patients with schizophrenia is associated with motivational deficits and negative symptom severity, which in turn contributes to poor functional outcomes including excess morbidity and mortality as well as treatment nonresponse. Increased inflammation is associated with alterations in activation of the ventral striatum and the anterior insula, brain regions that subserve reward, effort, and motivation. This project will provide mechanistic insight into whether inflammation impacts these brain regions to contribute to motivational deficits in a subgroup of patients with schizophrenia and will provide a foundation for personalized treatments that reduce inflammation to ultimately reverse the devastating impact of amotivation and negative symptoms in patients with schizophrenia and increased inflammation.

PI_NAMEs: GOLDSMITH, DAVID RYAN (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Address;Anhedonia;antagonist;Anterior;Anti-Inflammatory Agents;Antipsychotic Agents;Behavior;Behavioral;Biological Markers;biomarker driven;blood oxygen level dependent;Brain;brain behavior;Brain region;C-reactive protein;Cells;Clinical;Clinical assessments;Clinical Trials;cognitive system;Corpus striatum structure;cytokine;Data;depressive symptoms;design;Development;Dimensions;Double-Blind Method;Enrollment;Exhibits;Expenditure;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;functional outcomes;Future;Gene Expression;Goals;Immune;Impairment;improved;Individual;Inflammation;Inflammatory;inflammatory marker;infliximab;innovation;insight;Insula of Reil;Literature;male;Measures;Mediating;Mental Depression;Mental disorders;Morbidity - disease rate;mortality;motivated behavior;Motivation;National Institute of Mental Health;Nature;neurobiological mechanism;novel;patient subsets;Patients;Performance;Peripheral;peripheral blood;personalized medicine;Pharmaceutical Preparations;Placebos;Plasma;pleasure;Positive Valence;Precision therapeutics;Publishing;Punishment;Randomized;Research;Research Domain Criteria;response;Rest;reward anticipation;reward processing;Rewards;Sampling;Schizophrenia;Severities;sex;Signal Transduction;Specificity;Stimulus;Strategic Planning;Subgroup;Symptoms;System;Testing;TNF gene;Ventral Striatum;women patients;Work

PROJECT_TITLE: Targeting Inflammation-Induced Changes in Brain Reward Signaling and Motivational Deficits in Patients with Schizophrenia Using an Anti-Inflammatory Challenge

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: ES

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Through targeted one-on-one mentoring between faculty and undergraduate students from communities underrepresented in the sciences, ROUTES seeks to increase engagement of underrepresented minorities (URMs) in the increasingly complex field of environmental health (EH) research. ROUTES will establish a multidisciplinary program centered around meaningful EH research experiences in industry, government, and non-profit sectors as well as on-campus funded research projects. Through integration with existing on campus P42 and T32 training programs, ROUTES will provide training, professional development, and networking opportunities to encourage URM students to pursue research careers in EH.

PI_NAMEs: SHEAHAN, THOMAS CLAIR (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Address;Affect;Area;Award;Basic Science;career;Career Choice;Communities;community building;community engagement;Complex;Cost Sharing;Data Science;design;Development;Discipline;Ecosystem;Education;Educational Curriculum;Educational workshop;Employment;Engineering;Environmental Health;environmental justice;Environmental Policy;Environmental Science;experience;Faculty;faculty mentor;faculty research;Financial Support;Funding;Goals;Government;Grant;hands on research;Health Sciences;improved;Industry;Institutionalization;interest;Learning;lectures;Life;meetings;member;Mentors;Methods;minority communities;minority undergraduate;Modeling;multidisciplinary;Nature;Nonprofit Organizations;outreach;Participant;Pathway interactions;Positioning Attribute;Process;Program Evaluation;Program Sustainability;programs;Puerto Rico;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Science;Scientist;Services;skills;Social Sciences;Structure;student participation;Students;success;Superfund;symposium;synthetic biology;Time;Training;Training Activity;Training Programs;Translational Research;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Wages;Work

PROJECT_TITLE: Research Opportunities for Undergraduates: Training in Environmental Health Sciences (ROUTES)


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: NARRATIVE Sarcoma are metastatic and aggressive tumors, for which therapies have not improved in the last years. Novel studies have been impeded by the paucity of appropriate experimental tools and reliable mouse models. Accordingly, we propose: i) to generate and characterize novel reliable sarcoma mouse models that carry the most frequent genetic alteration found in patients ii) illuminate the expression profile of the sarcoma cells and discrete sub-clusters of them, to understand how these profiles influence the TME composition, and iii) to test how these models respond to different radiotherapy administration schedules.

PI_NAMEs: GUARNERIO, JLENIA  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Adult;Affect;Aftercare;Animal Model;Architecture;biomarker discovery;biomarker identification;Caring;Cells;Chemotherapy and/or radiation;Clinic;clinical development;clinical practice;Clinical Research;Clinical Trials;comparative;Complex;conventional therapy;Cytometry;Data;Development;dimensional analysis;Dimensions;DNA Sequence Alteration;Elements;Employment;flexibility;Genetic;Goals;high dimensionality;Human;Image;Immune;Immunocompetent;Immunotherapy;improved;Incidence;Individual;innovation;Intervention;Karyotype;Knowledge;leiomyosarcoma;Lung;Mesenchymal;Mesenchymal Cell Neoplasm;Metastatic Neoplasm to the Lung;Metastatic to;Methods;Modeling;Molecular;mouse model;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;new technology;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Pathway interactions;Patients;prevent;Primary Lesion;Radiation therapy;Recurrence;Recurrent disease;Regimen;Relapse;Residual Neoplasm;Resistance;response;Sampling;Sarcoma;Schedule;Signal Pathway;single-cell RNA sequencing;Soft tissue sarcoma;Subgroup;System;targeted treatment;Testing;The Cancer Genome Atlas;therapeutically effective;therapy resistant;tool;Transcription Alteration;Translating;Transplantation;treatment response;tumor;Tumor Burden;Tumor Markers;tumor microenvironment;Undifferentiated

PROJECT_TITLE: Comparative modeling of sarcoma microenvironments for the discovery of biomarkers and tumor vulnerabilities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-N(55)R]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Precision Medicine

ORG_CITY: OMAHA

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Name of Principal Investigator: Sean N. Avedissian Project Narrative My long-term goal is to become an independent investigator in translational and clinical pharmacology of antiretroviral drugs (ARVs) focused on HIV reservoirs. The goal of this application is to advance significantly my career development, through didactic coursework and mentored research, and develop expertise in the field of central nervous system-focused HIV pharmacology. The research proposal includes both clinical and translational work fundamental to understanding ARV drug penetration and activity in the central nervous system in people with HIV. Data from these experiments will guide future approaches to design ARV regimens optimal for treatment of people with HIV infection who develop HIV-associated neurocognitive dysfunction.

PI_NAMEs: AVEDISSIAN, SEAN  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: absorption;Acceleration;Address;Age;Agreement;AIDS clinical trial group;AIDS dementia;Anatomy;Animal Model;Animals;Anti-Retroviral Agents;antiretroviral therapy;Award;Basic Science;Biological Assay;Blood;blood-brain barrier crossing;Brain;brain endothelial cell;career;career development;CCL2 gene;Cell model;Central Nervous System;Cerebrospinal Fluid;Characteristics;Clinical;Clinical Pharmacology;Clinical Research;clinical translation;clinically significant;co-infection;cohort;Cohort Studies;college;comorbidity;Data;design;Detection;Development;didactic education;Discipline of Nursing;Doctor of Philosophy;Drug Exposure;Drug Kinetics;Drug usage;Ensure;Ethics;Excretory function;experimental study;Exposure to;Extramural Activities;Faculty;Functional disorder;Funding;Future;Goals;Hand;high risk;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human;Human body;IL6 gene;Immune response;improved;In Vitro;in vitro Model;in vivo;Individual;innovation;Institution;interpatient variability;Investigation;Life Expectancy;Link;Liquid substance;Literature;Measures;Medical center;member;memory CD4 T lymphocyte;Mental disorders;Mentored Patient-Oriented Research Career Development Award;Mentors;Metabolism;Mission;Monkeys;monolayer;multidisciplinary;Names;National Institute of Mental Health;Nebraska;Neopterin;Neurocognitive;Neurocognitive Deficit;neuroinflammation;Neurologic;novel;novel strategies;older patient;optimal treatments;Participant;Pathogenesis;Pathway interactions;patient oriented research;patient variability;Patients;Penetration;Performance;personalized medicine;Persons;Pharmaceutical Preparations;pharmacokinetic model;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Physiological;Plasma;Population;Prevention;Primates;Principal Investigator;Productivity;professor;programs;Property;prospective;Recovery;Regimen;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;response;responsible research conduct;RNA;Sampling;Scholars Program;Scientist;Severities;SIV;skill acquisition;sound;Structure;Techniques;Testing;Therapeutic;Tissue Sample;Tissues;Training;Translational Research;translational scientist;Translations;United States National Institutes of Health;Universities;Viral;Viral Load result;Viral reservoir;Virus;Work

PROJECT_TITLE: Investigations of antiretroviral therapy penetration in cerebrospinal fluid

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CAMDEN

ORG_NAME: CORIELL INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NJ

PHR: Narrative Acute myeloid leukemia (AML) is a life-threatening blood disease. Many new drugs targeting newly identified genetic mutations in AML are demonstrating promising effect in clinical studies. However, one major obstacle to greater success with targeted therapy of leukemia is drug resistance. To understand the resistance to a potential clinical drug AC220 of AML, we have carried out a genetic screen to study the mechanisms of resistance to AC220 in AML cells and discover a number of novel genes whose knockouts cause drug resistance to AC220. We will further explore the underlying mechanisms of acquired drug resistance in AML and translational potential of our findings.

PI_NAMEs: HUANG, JIAN  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: acquired drug resistance;Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;antagonist;beta catenin;Biochemical;Bone Diseases;Bone Marrow Diseases;cell growth;Cell Survival;Cells;Clinic;Clinical;Clinical Research;Clinical Treatment;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;CRISPR screen;Cytokine Receptors;Data;Development;Disease;DNA Sequence Alteration;Drug resistance;Family;FLT3 gene;Generations;Genes;genetic approach;Genetic Screening;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;in vivo;inhibitor;inhibitor therapy;insight;kinase inhibitor;Knock-out;Knowledge;Lead;Learning;leukemia treatment;Libraries;Life;Link;loss of function;Maintenance Therapy;Malignant - descriptor;MAP Kinase Gene;Mediator;MEKs;member;Mitogen-Activated Protein Kinases;Molecular;Molecular Abnormality;mouse model;Mutate;Mutation;new therapeutic target;novel;Pathway interactions;Patients;Pharmaceutical Preparations;Play;Positioning Attribute;Prognosis;Protein Tyrosine Kinase;Proteins;Receptor Protein-Tyrosine Kinases;Refractory;Regimen;Relapse;Reporting;Resistance;resistance mechanism;response;Role;Sampling;Series;Signal Pathway;Signal Transduction;small molecule;success;targeted treatment;Testing;Therapeutic;Translating;translational potential;Tyrosine Kinase Inhibitor;WNT Signaling Pathway

PROJECT_TITLE: Explore the signaling mechanisms of acquired resistance to tyrosine kinase inhibitors in AML

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: MADISON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Current treatment options for stroke are time-limited and require expertise, and equipment, that is not widely available to most patients who have suffered a stroke. This proposal is investigating the effect of blocking one of the known ways in which the immune system responds to stroke to determine if this approach can lessen the damage that occurs after stroke. The overall goal of these studies is to obtain more information needed to develop different treatment options that can improve outcomes from stroke.

PI_NAMEs: FAMAKIN, BOLANLE  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Acute;Adhesives;Affect;Antibodies;Astrocytes;Attenuated;Award;behavioral outcome;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Brain;Brain Injuries;career;Cell Survival;Cells;Cerebral Ischemia;cerebral microvasculature;clinically relevant;Complement;Data;deprivation;Development;Equipment;Excision;Extravasation;flexibility;Fluorescence;foot;Foundations;Funding;Gelatinase B;Gene Expression;Genetic Recombination;Glucose;Goals;HMGB1 gene;Hypoxia;Immune;immune activation;Immune system;Immunoglobulin G;Immunohistochemistry;immunoregulation;improved;improved outcome;in vitro Model;in vivo;Incubated;Inflammation;injured;Ischemia;Knowledge;Lead;Ligands;Macrophage;Mechanics;Mediating;Microglia;Middle Cerebral Artery Occlusion;Modeling;Molecular;Mus;Natural Immunity;neurobehavioral;neuron loss;neurovascular;neurovascular unit;novel therapeutics;Outcome;Oxygen;Pathway interactions;Patients;Pattern;Permeability;Phase;phosphoproteomics;post stroke;Process;Rattus;Recombinants;Research;response;Role;Serum;Signal Induction;Signal Pathway;Signal Transduction;Specificity;Stains;Stroke;stroke outcome;stroke therapy;Tamoxifen;Testing;Therapeutic;thrombolysis;Time;tissue injury;Tissues;TLR4 gene;Toll-like receptors;transcriptome sequencing;transcriptomics;Validation;Vascular Permeabilities;Walking;Western Blotting

PROJECT_TITLE: Astrocyte-specific TLR4 signaling and Blood Brain Barrier permeability following acute focal cerebral ischemia

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Palliative Care;Pediatric

ORG_CITY: SEATTLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE  The proposed study is responsive to the mission of the research priorities of the National Institute of Nursing Research and the National Cancer Institute: to reduce health disparities for racially, ethnically, and financially disadvantaged persons, including promoting and improving the quality of life of individuals and families. It is directly related to evidence-based palliative care to enhance psycho-behavioral adjustment to trauma-exposed parents and children impacted by a parent's life-threatening illness.

PI_NAMEs: LEWIS, FRANCES MARCUS (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: advanced disease;Advanced Malignant Neoplasm;Affect;Age;alternative treatment;Anxiety;anxious;Behavioral;Bereavement;cancer care;Cancer Center;Child;Child Rearing;Competence;Competency-Based Education;Comprehensive Cancer Center;Control Groups;coping;Data;Depressed mood;design;Development;Diagnosis;Disparity population;Education;Educational Intervention;Educational workshop;efficacy evaluation;efficacy testing;Eligibility Determination;Emotional;emotional adjustment;Enrollment;Environment;Equation;Ethnic Origin;evidence base;experimental group;Factor Analysis;Family;Goals;Hawaii;Health;Home;improved;Individual;Informed Consent;Intervention;Intervention Studies;Interview;Knowledge;Language;Life;Malignant Neoplasms;Manuals;Measures;Mission;Modeling;National Cancer Institute;National Institute of Nursing Research;Newly Diagnosed;Oncology;Outcome;Palliative Care;Pamphlets;parent-child communication;Parent-Child Relations;parenting intervention;Parents;Participant;Patient Education;Patients;Personal Communication;Persons;Phase;pilot test;primary endpoint;primary outcome;programs;Protocols documentation;psychosocial;Quality of life;racial health disparity;Randomized;Randomized, Controlled Trials;recruit;Recurrent disease;Reduce health disparities;Research Priority;response;Sampling;Self Efficacy;service providers;skills;skills training;social cognitive theory;South Carolina;Symptom Burden;Tail;Telephone;telephone delivery;Testing;Theoretical model;theories;Time;TNM;Training;trauma exposure;Treatment Efficacy;Treatment Failure;Treatment outcome;tumor;United States;Universities;virtual;Washington;Workplace;Writing

PROJECT_TITLE: Enhancing Connections-Palliative Care: A Cancer Parenting Program for Patients with Advanced Cancer and Their Children

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The overall objective of this proposal is to refine our understanding of the impacts of home health care, early outpatient care, and Medicare Advantage after hospitalization for acute myocardial infarction (AMI) in older persons by examining their effects in the context of functional impairments and illness severity. We will focus on outcomes of primary importance to older patients, including “home days” (days alive out of the hospital and other inpatient facilities) and health status. This hypothesis-driven research will leverage the most comprehensive set of data on functional impairments and geriatric conditions collected during AMI hospitalization on a large, national cohort to inform strategies to improve outcomes of importance to older patients.

PI_NAMEs: CHAUDHRY, SARWAT I (contact)

PROGRAM_OFFICER_NAME: TATAW-AYUKETAH, GLADYS OROCK

PROJECT_TERMS: Accounting;Acute myocardial infarction;Address;Affect;Age;Aging;Ambulatory Care;Biometry;Cardiac Catheterization Procedures;Cardiovascular system;care delivery;Cognition;cohort;Collaborations;comorbidity;Cost Control;Data;Data Set;Data Sources;depressive symptoms;Diagnostic tests;Discharge Plannings;Disease;Echocardiography;Effectiveness;Elderly;Enrollment;Epidemiology;Evaluation;Event;evidence based guidelines;Financial Hardship;follow-up;Functional impairment;Gait speed;Geriatric Assessment;Health Benefit;Health Status;Health system;Healthcare;high risk;Home;Home Care Services;hospital care;hospital readmission;Hospitalization;Hospitals;improved;improved outcome;Incentives;Inpatients;Insurance Coverage;Interview;Measures;Medical Records;Medicare;Modeling;mortality;mortality risk;National Heart, Lung, and Blood Institute;older adult;older patient;Older Population;Outcome;Outpatients;participant enrollment;participant interview;Patient Discharge;Patient Outcomes Assessments;Patients;payment;performance based measurement;Physiological;primary outcome;Prognosis;programs;Reporting;Research;Risk;risk prediction;risk prediction model;Services;Severity of illness;Social support;Techniques;Time;Visit

PROJECT_TITLE: Effectiveness of Strategies to Improve Outcomes after Hospitalization for Acute Myocardial Infarction in Older Adults

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Neonatal clinical trials have difficulty including diverse populations of infants, such as those whose parents are racial or ethnic minorities, report lower income, or have lower educational attainment. Under-representation of these populations results in an evidence base that may not be generalizable, which is particularly problematic because these infants are at higher risk for worse outcomes for many common neonatal problems and associated morbidity, mortality, cost, and long-term disabilities. The proposed project will describe how parents make enrollment decisions and create and pilot test a modified recruitment approach designed to improve the recruitment process and to increase participation of under-represented populations in neonatal research.

PI_NAMEs: WEISS, ELLIOTT M (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: acceptability and feasibility;Address;Advisory Committees;Agreement;Area;Black race;career development;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;cohort;Complex;cost;Data;data integration;design;Education;efficacy evaluation;Eligibility Determination;Enrollment;Environment;Erythropoietin;Ethics;ethnic minority;evidence base;experience;extreme prematurity;Familiarity;Family;Family Process;feasibility testing;Foundations;Future;Goals;Grant;Health;health disparity;health literacy;high risk;improved;improved outcome;Income;Infant;Informed Consent;Intervention;intervention mapping;Interview;K-Series Research Career Programs;Knowledge;Learning;Long term disability;Low income;Medicaid;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Morbidity - disease rate;mortality;multidisciplinary;Neonatal;neonatal hypoxic-ischemic brain injury;Neuroprotective Agents;Operations Research;Outcome;Parents;Participant;Patients;pilot test;Population;Population Heterogeneity;Procedures;Process;Publications;racial minority;Randomized, Controlled Trials;recruit;Reporting;Research;Research Ethics;Research Personnel;Sampling;Shapes;Site;skills;sound;Structure;Surveys;Techniques;Testing;theories;therapy development;Training;Underrepresented Populations;Work;working group

PROJECT_TITLE: Improving Diversity in Neonatal Clinical Trial Enrollment

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases;Spina Bifida

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative This proposal aims to elucidate the molecular and cellular mechanisms underlying Neural tube defects (NTDs), that are among the most common birth defects in humans. To achieve this, we will utilize a novel mouse model of NTDs that has a failure of cranial mesenchyme expansion and neural fold elevation. Our findings will yield mechanistic insights into the causes of NTDs, elucidate the contribution of an understudied process driving neural tube closure and implicate an important candidate gene for genetic counseling.

PI_NAMEs: ZOHN, IRENE E (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Address;Alleles;Anencephaly;Automobile Driving;Biochemical;Biological Assay;Candidate Disease Gene;Cell division;Cell Lineage;cell motility;cell type;Cells;Cephalic;Cessation of life;Congenital Abnormality;Data;defined contribution;Development;Disease;DNA Sequence Alteration;Embryo;experimental study;extracellular;Failure;gain of function;Genes;Genetic;Genetic Counseling;Heat-Shock Proteins 90;Histologic;Human;Image;imaging approach;inhibitor;innovation;insight;Knowledge;Label;Laboratories;Light;Link;Long term disability;loss of function mutation;Mediating;Mesenchyme;Microscopy;migration;Molecular;Morphogenesis;mouse model;Movement;Mus;mutant;mutant mouse model;Mutant Strains Mice;Mutation;neural;Neural Crest;Neural Fold;neural plate;Neural Tube Closure;Neural Tube Defects;novel;Paraxial Mesoderm;Pathogenicity;Pathway interactions;Patients;Pattern;pharmacologic;Population;Process;Production;Regulation;Resolution;Series;Signal Transduction;SOX1 gene;Structural Congenital Anomalies;Study models;Testing;Time;Tissue Recombination;Tissues;tool;Tretinoin;Variant;Visualization;Work

PROJECT_TITLE: Regulation of Cranial Mesenchyme Expansion Driving Neural Fold Elevation

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: Auburn

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: PROJECT NARRATIVE Sleep disturbances are prevalent and contribute to mental and physical health problems, cognitive difficulties and physiological dysregulation - significant public health problems. Health disparities in sleep along socioeconomic and racial/ethnic lines and their consequences on long-term trajectories of health and adaptation from childhood through early adulthood are essentially unknown. This study will create new knowledge by identifying mechanisms that explicate when and why socio-economic and racial disparities in sleep emerge, and by elucidating the long-term effects of sleep disturbances in the development of broader health disparities from childhood through early adulthood.

PI_NAMEs: EL-SHEIKH, MONA M (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: actigraphy;Address;Adolescence;Adolescent;Age;Alabama;American;Area;Attenuated;Autonomic nervous system;Behavioral;biological adaptation to stress;Black race;Childhood;Chronic;circadian biology;Cognitive;cognitive function;Computer software;Data;Data Set;design;Development;Developmental Process;Disparity;Distal;Economically Deprived Population;Education;emerging adult;Environment;ethnic disparity;Ethnic Origin;Family;Goals;Health;health disparity;Impairment;indexing;Individual;Intervention;Investigation;Knowledge;Link;Literature;Long-Term Effects;longitudinal design;low socioeconomic status;Measurement;Measures;Mediating;Mental Health;Methods;Minority Groups;Neighborhoods;novel;Outcome;Outcome Assessment;parent grant;Participant;perceived discrimination;Persons;physical conditioning;Physiological;poor sleep;Prevalence;prevent;Prevention;Procedures;protective factors;psychologic;Public Health;public health priorities;Questionnaires;Race;racial disparity;racial diversity;racial health disparity;racial population;Reproducibility;Research;Research Priority;retention rate;Risk;Role;Rural;Sampling;Schedule;Science;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;social;societal costs;socioeconomic adversity;socioeconomic disadvantage;socioeconomic disparity;socioeconomics;System;Testing;Time;transmission process;United States National Institutes of Health;Vocation;Woman;Wrist;young adult;Youth

PROJECT_TITLE: Sleep as a Mechanism and Moderator in the Development of Health Disparities

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE This proposal is aimed at defining how disruption of the circadian clock, both genetic and environmental, accelerates colorectal cancer pathogenesis. We propose that the circadian clock regulates Wnt/b-Catenin signaling, and disruption of this control results in aberrant gene expression and accelerated intestinal proliferation. Our molecular studies will provide new insight towards future directions for targeted therapeutic intervention of colorectal cancer that rely on pharmacological modulators of the circadian clock.

PI_NAMEs: MASRI, SELMA  (contact)

PROJECT_TERMS: Acceleration;Address;adenoma;age related;APC gene;Area;ARNTL gene;beta catenin;Biological Pacemakers;Cancer Control;cancer diagnosis;Cancer Etiology;cancer initiation;Cell Cycle;Cell Fate Control;Cell Maintenance;Cell Proliferation;Cells;Cessation of life;chemotherapy;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical;Colorectal Cancer;colorectal cancer treatment;Colorectal Neoplasms;Critical Pathways;Cues;Development;Disease Progression;Early Diagnosis;early screening;Endocrine;Epigenetic Process;Exhibits;Future;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Goals;Growth;Homeostasis;Hour;Human;In Vitro;in vivo;Incidence;insight;intestinal adenoma;Intestinal Cancer;Intestines;Jet Lag Syndrome;Knowledge;Light;Link;Maintenance;Malignant Neoplasms;Metabolism;Modeling;Molecular;molecular clock;Mutation;Neoplasm Metastasis;novel;Oncogenic;Organoids;Outcome;Pathogenesis;Pathology;Pathway interactions;pharmacologic;Physiological;Polyps;Population;programs;Proliferating;Regulation;Research;Role;Sex Differences;Signal Pathway;Signal Transduction;stem cells;targeted treatment;Therapeutic Intervention;therapeutic target;Tissues;transcription factor;tumor;tumor initiation;tumor progression;Tumor stage;United States;WNT Signaling Pathway;Work

PROJECT_TITLE: Circadian Clock Disruption and Colorectal Cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative  The spinal column is composed of neural and mesodermal tissues, and birth defects, such as scoliosis, that affect the spinal column can originate from abnormal development of either tissue. This project uses an innovative application of deactivated Cas9 technology to investigate how two transcription factors regulate mesodermal differentiation and migration of mesodermal progenitors in axis elongation critical in spinal column development. By elucidating the roles of these transcription factors this project will shed light on combinatorial gene function in development as well as the genetic and cellular dynamics of vertebrate body elongation.

PI_NAMEs: KINDBERG, ABIGAIL ALEXANDRA (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Address;Affect;Anterior;Biological Assay;bone;Candidate Disease Gene;Cell Differentiation process;cell motility;Cells;Cellular Morphology;combinatorial;Complex;Computer Assisted;Congenital Abnormality;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Data Analyses;deactivated CRISPR-Cas9;Development;Developmental Process;Down-Regulation;Embryo;Embryonic Development;Exhibits;Family;gain of function;gastrulation;Gene Expression;Gene Expression Profiling;gene function;gene regulatory network;Genes;Genetic;genetic analysis;Genetic Screening;Genetic study;Heat-Shock Response;Human;Image;Individual;innovation;interest;Lead;loss of function;malformation;member;Mesoderm;Messenger RNA;migration;Molecular;Morphogenesis;Morphology;Motion;Mus;mutant;Mutation;neural;Neural tube;novel strategies;Organism;Outcome;Pattern;Phenotype;Play;pleiotropism;Process;progenitor;recruit;Regulation;Repression;reverse genetics;Role;scoliosis;screening;Somites;somitogenesis;Spinal;stem cell differentiation;System;Tail;Technology;Time;Tissues;Transcription Coactivator;transcription factor;Transcription Repressor;transcriptome sequencing;Transgenes;Transgenic Organisms;Up-Regulation;Vertebral column;Visual;Work;Zebrafish

PROJECT_TITLE: Temporal Analysis of Combinatorial Gene Function during Vertebrate Body Elongation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative/Lay Summary: Glioma intelligence from behind enemy lines We used “microdialysis” to sample the biochemical signatures of living human brain cancers during neurosurgical procedures and identified high level of resiliency-promoting metabolites. We use neurosurgical access to human brain tumors to determine when, how and why these metabolites accumulate and how best to eliminate them, using microdialysis to evaluate progress in real time.

PI_NAMEs: BURNS, TERRY  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Astrocytoma;Biochemical;blood-brain barrier disruption;Brain;Brain Neoplasms;Catheters;Cells;Clinical;Clinical Research;Clinical Trials;clinically relevant;cohort;Combined Modality Therapy;Cystathionine;Data;DL-alpha-Difluoromethylornithine;Eflornithine;Excision;extracellular;Feedback;gain of function;Genetic;Genomics;Glioblastoma;Glioma;Glutathione;Glutathione Disulfide;guanidinoacetate;Human;human data;Image;Implant;improved outcome;In Situ;Intelligence;Investigational Therapies;Knowledge;Lesion;loss of function;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methionine;Methionine Metabolism Pathway;Microdialysis;Modeling;Molecular;Molecular Weight;Monitor;neurosurgery;Neurosurgical Procedures;novel;novel strategies;Ornithine;Ornithine Decarboxylase;Ornithine Decarboxylase Inhibitor;Pathway interactions;Patients;Pharmacodynamics;pharmacologic;Phase;Phase 0 Study;Phenotype;Polyamines;Pre-Clinical Model;preclinical study;promote resilience;Radiation;Randomized;Recurrence;Reproducibility;research clinical testing;Resected;resilience;Resistance;Safety;Sampling;Sorting;Source;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;stable isotope;standard of care;Stress;Stromal Cells;success;targeted treatment;Testing;Therapeutic;Therapeutically Targetable;Time;Tissues;translational progress;tumor;Tumor Escape;Tumor Tissue;Up-Regulation;uptake;Xenograft procedure

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Regenerative Medicine

ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE A long-term goal of medicine is to regenerate injured or diseased tissues. Animals that can regenerate structures naturally, such as salamanders, will provide key lessons that can inform regenerative therapies. Our study will provide new knowledge on the mechanisms that regulate patterning of the regenerating limb and should stimulate new regenerative approaches in mammalian systems.

PI_NAMEs: MONAGHAN, JAMES R (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Adopted;Affect;Agonist;Ambystoma;Ambystoma mexicanum;Amputation;Animals;Back;Birth;blastema;Cell Reprogramming;Cell surface;Cells;Child;chondrodysplasia;clinically relevant;Congenital Abnormality;Connective Tissue Cells;CRISPR/Cas technology;Deformity;disability;Disease;Distal;Engineering;Epigenetic Process;epithelial wound;Event;Fluorescent in Situ Hybridization;Future;Gene Expression;Genes;Genetic;Genetic Transcription;Genomic approach;Goals;Grant;Human;in vivo;Individual;injured;insight;knockout gene;Knowledge;Laboratories;Ligands;Limb Development;limb regeneration;Limb structure;Mediating;Medicine;Memory;Modification;Molecular;Molecular Target;morphogens;Natural regeneration;Outcome;Pattern;pharmacologic;Play;predictive modeling;Process;progenitor;programs;Prosthesis;receptor;regenerative;regenerative approach;regenerative biology;Regenerative Medicine;Regenerative research;regenerative therapy;Resolution;Retinoic Acid Receptor;retinoic acid receptor alpha;retinoic acid receptor gamma;Role;Salamander;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Site;skeletal;skeletal disorder;skeletal regeneration;Structure;System;Testing;Therapeutic;therapeutic target;Tissues;transcriptomics;Trauma;Tretinoin;United States

PROJECT_TITLE: Mechanisms of skeletal patterning during limb development and regeneration


NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the project is expected to have a positive impact by providing information on the mechanisms by which tumor suppressor p53 status determines estrogen receptor beta (ERβ) function in breast cancer, especially triple negative breast cancer (TNBC). There is an urgent need to identify novel targets and develop new therapies against TNBC because targeted therapies are not currently available against these aggressive cancers, and the remaining option, chemotherapy, is also relatively ineffective. The proposed study will facilitate better understanding of ERβ and p53 signaling crosstalk and has the potential to facilitate developing new therapeutic strategies against TNBC, and therefore, is relevant to the part of NIH's mission that pertains to research on causes, diagnosis, prevention, and cure of human diseases.

PI_NAMEs: DAS, GOKUL M. (contact)

PROJECT_TERMS: Affect;Apoptosis;Archives;Basal Cell;Binding;Breast Cancer Cell;Breast Cancer Patient;Cancer Biology;Carboplatin;Cell model;Cell Physiology;Cells;Characteristics;chemotherapy;Clinical;Clinical Data;clinical database;clinically relevant;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;CRISPR/Cas technology;Data;Development;Diagnosis;Disease Progression;Disease stratification;Dominant-Negative Mutation;Doxorubicin;Drug Targeting;Epidermal Growth Factor Receptor;ESR1 gene;Estrogen Receptor 2;Frequencies;gain of function;Goals;Growth;Hot Spot;Human;human data;human disease;In Vitro;in vivo;Individual;Induction of Apoptosis;innovation;insight;Invaded;knock-down;Laboratories;Lead;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mission;Molecular;mouse model;mutant;Mutation;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Organoids;overexpression;Pathology;patient derived xenograft model;Patients;pre-clinical;Prevention;Process;Progesterone Receptors;Property;Proteins;Public Health;receptor expression;Receptors, Adrenergic, beta-1;Regimen;Regulation;Reporting;Research;Resistance;response;Role;Signal Transduction;Site;small hairpin RNA;Subgroup;Survival Analysis;Tamoxifen;targeted treatment;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;TP53 gene;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor progression;Tumor Suppressor Proteins;Tumor Tissue;Tumor-Derived;tumorigenic;United States National Institutes of Health;Validation;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Functional Significance of individual p53 mutations in determining the role of estrogen receptor beta in triple negative breast cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Contact PI: Reddy, Julia PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on provider and policy responses to prenatal substance exposure and the custody outcomes of affected infants. It will also inventory best practice policies and tools perceived by labor and delivery providers as able to improve policy consistency and mitigate the consequences of maternal substance use disorders, which responds to NIDA’s mission to increase the applicability of research in real-world contexts. By examining both the implementation and outcomes associated with nonuniversal prenatal substance exposure-related child protection system reporting policies, the proposed research is responsive to NIDA’s Strategic Plan Goal 4, to assess the impact of policies related to drug use and substance use disorders on public health and well-being.

PI_NAMEs: REDDY, JULIA  (contact)

PROGRAM_OFFICER_NAME: VIDAL, SARAH

PROJECT_TERMS: addiction;Address;Adherence;Adoption;Advocate;Affect;Age;Alcohol consumption;Area;Attenuated;Biological;Birth;Birth Records;California;career;Categories;Characteristics;Child;Child Abuse and Neglect;child protection;cohort;Communities;cost;County;Data;Data Science;Data Set;demographics;design;Development;Diagnosis;Diagnostic;Drug usage;Effectiveness;Environment;Epidemiology;Equipment and supply inventories;Equity;experience;Family;Fellowship;fetal substance exposure;foster care;Future;General Population;Goals;high risk;Home;hospital analysis;Hospitals;improved;Incidence;Individual;Infant;innovation;insight;Institution;Insurance;interest;Interruption;Intervention;Interview;Knowledge;lens;Life;Link;Literature;Logistic Regressions;Los Angeles;maltreatment;Mentors;Mentorship;Methods;Mission;multilevel analysis;National Institute of Drug Abuse;Neonatal;neonatal period;Outcome;patient population;Pattern;Performance;Personal Satisfaction;Pharmaceutical Preparations;Play;Policies;Policy Analysis;Policy Maker;Population Characteristics;postnatal;Pregnancy;prevent;programs;Provider;provider behavior;Public Health;Race;Records;Recurrence;Reporter;Reporting;Research;Research Personnel;response;Risk;risk mitigation;Role;Sample Size;Scholarship;secondary analysis;skills;Standardization;statistics;Strategic Planning;Structure;substance use;Substance Use Disorder;System;tool;Training;United States;Update;Variant;Woman;women's diagnosis

PROJECT_TITLE: Implementation and Outcomes of Child Protection System Reporting Policies Regarding Infants Born with Prenatal Substance Exposure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)L]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Lung;Prevention;Social Determinants of Health;Vaccine Related

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE There is a pressing need to develop and implement plans for COVID-19 pandemic response and control for low- and middle-income countries (LMICs). Prevention science, with mathematical models and related approaches, supports epidemic planning and preparedness, but must be based upon context-specific epidemiological parameters for maximal utility. In this study, we will identify COVID-19-specific parameters for low-income settings to be implemented in mathematical models for prevention and pandemic response.

PI_NAMEs: LOPMAN, BENJAMIN A;OMER, SAAD B. (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Age;age related;Antibody Avidity;antibody test;Antibody titer measurement;Area;B-Cell Activation;Blood specimen;Communities;Country;COVID-19;COVID-19 incidence;COVID-19 pandemic;COVID-19 prevention;COVID-19 vaccine;Data;Decision Making;Disease;Disease Surveillance;disease transmission;Environment;epidemic preparedness;epidemiological model;Epidemiology;face mask;Family member;Fatality rate;Future;Grant;Guatemala;Healthcare;Heterogeneity;Household;Human;Immunoglobulin G;Incidence;India;Infection;Influenza;Infrastructure;Intervention;Investigation;Longitudinal cohort;low and middle-income countries;Low income;mathematical model;Measures;member;Modeling;Mozambique;network models;Network-based;pandemic preparedness;pandemic response;Parameter Estimation;Participant;Pattern;Policies;Prevention;Probability;Research;Resource-limited setting;Resources;respiratory;Respiratory Disease;respiratory pathogen;Respiratory Tract Infections;response;Rural;Sampling;SARS-CoV-2 transmission;school closure;Science;Seroprevalences;social;Social Interaction;Specimen;Structure;Testing;Time;transmission process;Update;Vaccination;vaccine distribution;Work

PROJECT_TITLE: COVID Global Mix - Global Mix / Investigation of COVID-19 Disease Parameters for Transmission Models in Low-Resource Settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Antibiotic resistance, due to antibiotic overuse, is a major threat to human health, and if unchecked will fundamentally alter the landscape of healthcare. This proposal will clarify effective ways to implement and assess the safety of diagnostic stewardship programs to reduce antibiotic use in critically ill children and will identify strategies to disseminate diagnostic stewardship programs.

PI_NAMEs: MILSTONE, AARON M (contact)

PROGRAM_OFFICER_NAME: LIN, LEYI

PROJECT_TITLE: Respiratory Culture Stewardship to Reduce Antibiotic Use in Critically Ill Children

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE This project is relevant to public health because it aims to improve the safety of nursing care delivered in neonatal intensive care units (NICUs). The research is significant because it will improve neonatal patient safety by changing the way nursing workload in the NICU is measured and used for workload management, organizational learning, and improvement. The project is innovative because it will use data readily accessible in electronic health records to develop a new multi-level model of workload for registered nurses and use this model to guide the design and development a future clinical decision support tool for workload management and safety improvement.

PI_NAMEs: FRANCE, DANIEL JOSEPH (contact);GURSES, AYSE PINAR

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Realtime Measurement of Situational Workload in NICU Nurses to Improve Workload Management and Patient Safety

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Nutrition

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative The proposed research is relevant to public health since it focuses on dissecting the mechanisms underlying the regulation of a highly conserved signaling complex (TORC1) known to play an important role in cancer development, diabetes, obesity and depression. The work may also reveal differences between the pathways that control cell growth in lower eukaryotes and humans--opening the door to creating drugs that can selectively block the growth of fungal pathogens.

PI_NAMEs: CAPALDI, ANDREW PAUL (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Amino Acids;Binding;Binding Proteins;Biochemical;biological adaptation to stress;cell growth;Cells;Cellular Metabolic Process;Complex;Data;Development;Diabetes Mellitus;Diphosphates;Disease;Dissection;Drug Design;Enzymes;Epilepsy;Eukaryota;Event;experimental study;Exposure to;fly;follow-up;G-Protein-Coupled Receptors;Genetic;Glucose;Grant;Growth;Guanosine Triphosphate Phosphohydrolases;hormonal signals;Hormones;Human;Hyperactivity;improved;innovation;inorganic phosphate;Inositol;Investigation;Knock-out;Lysosomes;Malignant Neoplasms;Maps;Membrane Proteins;Mental Depression;model organism;Monomeric GTP-Binding Proteins;Movement;Mus;Nitrogen;Nutrient;Obesity;pathogenic fungus;Pathway interactions;Pharmaceutical Preparations;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;Prions;protein function;Proteins;Proteomics;Public Health;Regulation;Repression;Research;Role;Saccharomyces cerevisiae;Saccharomycetales;Serine;Signal Pathway;Signal Transduction;Sirolimus;Starvation;Stress;Sulfur;System;Testing;Time;transmission process;Vacuole;Work;Yeasts

PROJECT_TITLE: Dissection of the TORC1 Signaling Network in Yeast

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Prevention

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH Age is the primary risk factor for the leading causes of disability and death, and interventions are needed to slow the rate of aging and improve health. In order to develop and test emerging interventions, we need accurate indices of aging processes. The proposed studies will validate a metric of biological aging that will be used to predict human healthspan, accelerate clinical trials to intervene on the aging process, and improve human healthspan.

PI_NAMEs: WANAGAT, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acceleration;Affect;Age;age related;Aging;aging process;anti aging;biological age;Biological Aging;Biological Assay;Biopsy;Blood;Brain;Caloric Restriction;Cardiovascular Diseases;Cause of Death;Cell Death;Cell Death Induction;Cell Physiology;Cells;Cerebrospinal Fluid;Cessation of life;Chronology;Clinical;clinical translation;Clinical Trials;clinically relevant;Clonal Deletion;Collaborations;Deletion Mutation;detection limit;Development;digital;disability;Disease;DNA;effectiveness measure;Effectiveness of Interventions;Electron Transport;Equation;Evaluation;Exercise;experimental study;Fiber;Frequencies;Funding;Genome;Geroscience;Goals;Growth;Guidelines;Health;healthspan;healthy aging;Heart;Human;human tissue;improved;indexing;Individual;Intervention;Intervention Trial;Kidney;Kidney Diseases;life span;Longevity;longitudinal human study;Measures;Metabolic Diseases;Metformin;Methods;Mitochondrial DNA;modifiable risk;Molecular;Morbidity - disease rate;mortality;Muscle;muscle aging;Muscle Fibers;Neurocognitive;novel;Outcome;Oxidative Phosphorylation;Patients;Phenotype;Physical Performance;Physiological;Prediction of Response to Therapy;predictive marker;Public Health;rate of aging;Replication Error;Resources;response;Risk Factors;risk prediction;Rodent;Sampling;sex;Skeletal Muscle;Skin;Solid;Spinal Cord;Testing;Tissue Banks;tissue degeneration;Tissue Sample;Tissues;treatment trial;Urine;Validation;vastus lateralis;Woman

PROJECT_TITLE: Mitochondrial DNA Deletion Mutation Frequency as a Metric of Biologic Age

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Mild Cognitive Impairment: A Prospective Community Study. This study of dementia and cognitive decline is being conducted in a population-based cohort of older adults from a “Rust Belt” community of relatively low socio-economic status. The overall goal of the study is to identify factors which might increase risk of dementia and cognitive decline, so that steps can be taken to reduce these risks, thus reducing the risk of dementia and improving the health of older adults in the community.

PI_NAMEs: ANDREESCU, CARMEN ;GANGULI, MARY  (contact);SNITZ, BETH

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Abbreviations;actigraphy;Adult;Age;aged;Alleles;Alzheimer disease screening;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Area;Back;Biological Assay;Biological Markers;biomarker identification;Blood;Brain;Brain scan;Candidate Disease Gene;causal model;cerebrovascular;Cerebrovascular Disorders;cerebrovascular imaging;Cessation of life;Clinical;clinically relevant;Cognitive;cognitive performance;cohort;Cohort Studies;Communities;comorbidity;Data;Dementia;dementia burden;dementia risk;Diagnosis;diagnostic criteria;differential expression;disability;Disease;Disease Marker;Education;Etiology;Gender;Gene Expression;Genes;Genetic;genetic variant;genome wide association study;genome-wide;Genomics;Glossary;Goals;Health;Healthcare;healthy aging;Hemorrhage;Heterogeneity;human old age (65+);Image;Impaired cognition;improved;Incidence;Infarction;insight;Investigation;Light;Literature;low socioeconomic status;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measures;Mediating;Mediation;Medical;men;Mendelian randomization;Mental Depression;Microvascular Dysfunction;mild cognitive impairment;Modeling;Names;novel;novel marker;older adult;Outcome;outcome prediction;Participant;Pennsylvania;Plasma;Population;population based;Population Study;Predictive Factor;Prevention;prospective;Public Health;Quantitative Trait Loci;Race;recruit;Risk;Risk Factors;Risk Reduction;Role;Sampling;Selection Bias;sex;Sleep;Sleep Wake Cycle;spelling;Subgroup;Techniques;Testing;time use;transcriptome sequencing;transcriptomics;Variant;Visualization;White Matter Hyperintensity;Woman;Work;Wrist

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Bioengineering

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project narrative Massive high-throughput studies with thousands of patients have been collected, but it is still extremely expensive to collect and process samples for individual studies. We propose to build on our work in developing statistical data sources, methods, software and training that facilitate and speed the work of our biological and medical collaborators.

PI_NAMEs: LEEK, JEFFREY T. (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Acute;Biological;Collection;Communities;Computer software;Congresses;cost;crowdsourcing;Data;Data Analyses;data resource;Data Sources;design;Development;Disease;experimental study;follow-up;Generations;Heart;high throughput technology;improved;Individual;large scale data;Measurement;Medical;Methods;Molecular;National Institute of General Medical Sciences;Patients;Process;public repository;recruit;Reproducibility;Research;Research Personnel;Running;Sample Size;Sampling;Source;Speed;Statistical Data Interpretation;Statistical Methods;Technology;tool;Training;training data;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Data analysis tools for leveraging massive public data to improve hypothesis-driven research

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Patient Safety;Radiation Oncology

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This grant supports OSUCCC's participation in the NCI's sponsored National Clinical Trials Network. OSUCCC offers clinical trial participation to all eligible patients to improve prevention of cancer, discover better cancer therapies, and boost the cure rates of adults with cancer. OSUCCC has one of the largest volume academic cancer centers in the US and is fully engaged in NCTN research with each of the existing NCI supported Operation Centers, and many other NCI initiatives.

PI_NAMEs: CARBONE, DAVID P.;CARSON, WILLIAM E.;CHAKRAVARTI, ARNAB ;O'MALLEY, DAVID MICHAEL;VERSCHRAEGEN, CLAIRE F. (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Address;Adult;Advisory Committees;Affect;Ally;Area;Award;Basic Science;Biochemistry;Biological Markers;Biomedical Research;Biometry;Biotechnology;Cancer Biology;Cancer Center;cancer clinical trial;Cancer Hospital;Cancer Patient;cancer prevention;cancer therapy;career;career development;CEBPA gene;Center for Translational Science Activities;Clinic;Clinical;Clinical Data;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Network;college;Comprehensive Cancer Center;confirmatory trial;Contracts;Credentialing;Data;data submission;Databases;Decitabine;Dedications;design;Discipline;Disease;doctoral student;drug development;Education;Educational process of instructing;Educational workshop;efficacy evaluation;Eligibility Determination;Enrollment;Environment;Epidemiologist;experience;Faculty;FLT3 gene;Fostering;Funding;Generations;Goals;Grant;Growth;Gynecologic Oncology;Health Personnel;Hematologic Neoplasms;Hematology;Hematopoietic Neoplasms;high standard;Image;Immunologics;Immunology;improved;improved outcome;Infrastructure;innovation;Inpatients;Investigational Therapies;investigator-initiated trial;Knowledge;Laboratory Scientists;Lead;Leadership;Learning;lenalidomide;leukemia;Malignant Neoplasms;Medical;Medical Oncology;meetings;Mentored Clinical Scientist Development Program;Mentors;minority patient;Modeling;Molecular Genetics;multidisciplinary;multimodality;National Clinical Trials Network;NCI Center for Cancer Research;next generation;novel;novel therapeutics;Nurses;Oblimersen;Ohio;operation;Operative Surgical Procedures;Outcome;Outpatients;participant enrollment;Pathologist;patient population;Patient-Focused Outcomes;Patients;Peer Review;Pentostatin;Performance;Pharmacists;Pharmacology;Phase;Physicians;Postdoctoral Fellow;pre-clinical;pre-doctoral;preclinical study;programs;Protocols documentation;Psychiatrist;Quality of life;Radiation Oncologist;Radiation Oncology;Radiation therapy;recruit;Reproduction spores;Research;Research Activity;Research Design;Research Institute;Research Personnel;research study;Resources;risk stratification;rituximab;Science;Scientist;Site;Solid Neoplasm;Structure;success;Support Groups;Surgical Oncologist;Surgical Oncology;Symptoms;targeted treatment;Therapeutic;Therapeutic Agents;Tissues;Toxic effect;Training;Translating;translational scientist;Translational trial;treatment trial;Tumor Biology;tumor heterogeneity;Universities;volunteer

PROJECT_TITLE: OSU as a Network Lead Academic Participating Site for the NCI NCTN


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

PHR: PROJECT NARRATIVE Prematurity is associated with a high prevalence of neuropsychological disability, even without major brain injury. This study seeks to identify early magnetic resonance imaging biomarkers of disturbed brain development, their association with ex-utero circulatory and oxygenation exposures of prematurity, and with neuropsychological outcome. Findings will inform specific targets for future interventions to improve neuropsychological outcomes.

PI_NAMEs: DU PLESSIS, ADRE JACQUES;LIMPEROPOULOS, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Acute;Address;Age;aging brain;Anatomy;Behavioral;Biological Markers;Bradycardia;Brain;Brain Injuries;Brain region;Caring;clinical trial readiness;Cognitive;Complex;Conceptions;cost;Critical Illness;Data;data acquisition;data repository;Databases;Development;disability;Dissociation;Early identification;Early Intervention;Effectiveness;Ensure;Environment;Environmental Exposure;Event;Evolution;fetal;Fetus;Functional disorder;functional outcomes;Future;Gestational Age;Goals;Growth;High Prevalence;Hypotension;Image;impaired brain development;Impairment;improved;in utero;Infant;Intervention;Investigation;Knowledge;Lesion;Link;Magnetic Resonance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;Metabolism;multimodal data;multimodality;Nature;neurodevelopment;neuroprotection;Neuropsychology;Outcome;Physiological;Play;Population;postnatal;Pregnancy;premature;Premature Birth;Premature Infant;Public Health;repository;Risk;Role;Serial Magnetic Resonance Imaging;Services;Signal Transduction;social;societal costs;Special Education;Survivors;System;Techniques;Time;tool;trend

PROJECT_TITLE: Impaired Brain Development in a Premature Ex-utero Environment

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Epilepsy;Eye Disease and Disorders of Vision;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative: Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830), a severe developmental and epileptic encephalopathy associated with cognitive and motor impairments and cortical visual impairment. While capability for disease modifying therapies is accelerating, there is a critical barrier for clinical trial readiness that may result in failure of these therapies, not due to lack of efficacy but due to lack of validated outcome measures and biomarkers. The measures and biomarkers validated here will be adaptable to other developmental and epileptic encephalopathies.

PI_NAMEs: BENKE, TIMOTHY A (contact);DOWNS, JENNY ;LEONARD, HELEN M;MARSH, ERIC D

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acceleration;Address;Animal Model;Behavior;Biological Markers;biomarker validation;CDKL5 disorder;cerebral visual impairment;Clinical;clinical outcome measures;Clinical Research;clinical trial protocol;clinical trial readiness;Clinical Trials;Communication;Consensus;Cyclin-Dependent Kinases;Data;Data Reporting;Databases;Development;disability;Disease;Electroencephalography;Ensure;Epilepsy;epileptic encephalopathies;Equipment and supply inventories;Evoked Potentials;experience;Family;Foundations;Future;gene therapy;Genes;Genetic;Goals;Hand functions;Impaired cognition;implementation evaluation;International;Interview;Knowledge;Maps;Measurement;Measures;Methods;Modification;Motor;motor disorder;motor impairment;Multi-Institutional Clinical Trial;National Institute of Neurological Disorders and Stroke;novel therapeutics;Outcome;Outcome Measure;Parents;Pathogenicity;Patients;Phenotype;Population;Positioning Attribute;potential biomarker;Protocols documentation;Qi;Quality of life;Reporting;Reproducibility;Research;Rest;Rett Syndrome;Severities;Site;Sleep;Structure;Symptoms;Testing;Therapeutic;tool;Training;Treatment Failure;Validation;Variant;Work

PROJECT_TITLE: Multi-Site Validation of Biomarkers and Core Clinical Outcome Measures for Clinical Trials Readiness in CDKL5 Deficiency Disorder


PHR: Project Narrative Osteoporosis and hypertension are major health concerns that lower lifespan and hinder the ability to remain independent and active as people age. This project will investigate pathways by which hypertension and aging activates the bone marrow to cause bone loss and weaken bone. By using established pre-clinical models of this disease and aging, the collaborative team with different but complementary expertise is well positioned to identify a new and translatable strategy for the prevention of fragility fractures.

PI_NAMEs: HARRISON, DAVID G (contact);NYMAN, JEFFRY STEPHEN

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Adult;Affect;Age;age related;age related decline;Age-Related Bone Loss;aged;Aging;aging related disease;American Heart Association;Animals;antagonist;Antibodies;arteriole;Biological Assay;Biology;Blood Pressure;blood pressure elevation;Blood Pressure Monitors;blood pressure reduction;bone;bone loss;Bone Marrow;bone mass;bone quality;Bone remodeling;Bone Resorption;bone strength;Cell Culture Techniques;Cell Differentiation process;Cells;Cessation of life;Clinical Pharmacology;Coculture Techniques;Collaborations;Communication;cytokine;Data;Dendritic Cells;Denervation;designer receptors exclusively activated by designer drugs;Deterioration;Diagnosis;Disease;disease model;Early Diagnosis;Early treatment;Economic Burden;Endothelial Cells;Endothelium;Enterobacteria phage P1 Cre recombinase;Estrogens;experimental study;Exposure to;Fracture;fracture risk;fragility fracture;Genes;Goals;Health;Hematopoietic;Hip Fractures;Human;Hypertension;hypertensive;IL17 gene;Immune;immune activation;improved;Individual;inducible Cre;Inflammation;Inflammatory;Interleukins;life span;long bone;Macrophage;Macrophage Colony-Stimulating Factor;mature animal;Measurement;mechanical force;Mechanical Stimulation;Mechanics;Mediating;Mediator;Menopause;Methodology;Modeling;Molecular;monocyte;mouse model;multidisciplinary;Mus;Mutant Strains Mice;Myeloid Cell Activation;Myeloid Cells;Myelopoiesis;neutralizing antibody;new therapeutic target;novel;novel therapeutic intervention;old mice;Older Population;Osteoblasts;Osteoclasts;Osteoporosis;Osteoporosis prevention;Pathway interactions;Patients;Persons;Phenotype;Play;Positioning Attribute;postnatal;Pre-Clinical Model;premature;prevent;Prevention strategy;Production;Qualifying;Quality of life;receptor;Recombinant Proteins;release factor;Research;Resistance;response;Role;Signal Transduction;skills;Societies;Source;Stimulus;Stretching;Structure;success;Sympathetic Nervous System;Systemic hypertension;T cell transcription factor 1;T-Cell Activation;Techniques;Technology;Testing;tool;translatable strategy;translational goal;treatment strategy;Vascular Endothelium;Vascular remodeling;vasoconstriction;venule;Withdrawal;Work

PROJECT_TITLE: Common Inflammation Pathways between Aging and Hypertension That Weaken Bone


NIH_SPENDING_CATS: Behavioral and Social Science;Genetics;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Childhood decrements in neurocognitive development result in large population burden and expenditure. The proposed research will identify the extent to which prenatal and postnatal neurotoxic mixtures as well as key prenatal nutrients jointly influence neurocognitive development in childhood. This research will provide early life biomarkers that reconstruct prenatal exposures and predict childhood neurocognitive performance with the goal of developing novel and early-life interventions to protect children.

PI_NAMEs: CARDENAS, ANDRES  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 3 year old;Address;Affect;Attenuated;autism spectrum disorder;Award;Biological Markers;biomarker development;Birth;Blood;Blood - brain barrier anatomy;Blood specimen;Chemicals;Child;Child Neurotoxicity;Childhood;clinical application;Cognition;cognitive ability;cognitive load;cognitive testing;cohort;cost;Data;Data Science;Dedications;design;Development;dietary;Dietary Intervention;DNA Methylation;early childhood;Environment;Environmental Exposure;Environmental Health;Epigenetic Process;Expenditure;exposed human population;Exposure to;Fetal Development;First Pregnancy Trimester;Folic Acid;Future;genome-wide;Goals;Heavy Metals;in utero;Individual;innovation;Intervention;Joints;Lead;learning ability;Learning Disabilities;Life;machine learning algorithm;machine learning method;Measures;Mercury;Metal exposure;Metals;Methodology;methylation biomarker;Methylmercury Compounds;Modeling;Modification;Neurocognitive;neurocognitive test;neurodevelopment;Neurodevelopmental Disorder;neurodevelopmental effect;neurotoxic;neurotoxicity;Neurotoxins;Newborn Infant;novel;novel marker;Nutrient;offspring;Outcome;Performance;Placenta;Plasma;Policies;Population;postnatal;Predisposition;prenatal;prenatal environmental exposure;prenatal exposure;programs;prospective;Public Health;Research;Resources;Risk;Risk Factors;routine screening;Source;Testing;toxicant;Umbilical Cord Blood;Vitamin B 12

PROJECT_TITLE: PRENATAL AND POSTNATAL EXPOSURE TO ENVIRONMENTAL MIXTURES: NEURODEVELOPMENT AND DNA METHYLATION BIOMARKERS


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: FARMINGTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Project Narrative Lynch syndrome (LS) is a hereditary disease which predisposes patients to an increased risk of developing colorectal and other extra-colonic cancers. Determining the mechanism by which loss of MMR contributes to tumorigenesis will aid in the diagnosis, prevention and treatment of these cancers. This proposal seeks to test whether loss of MMR leads to an immediate growth and/or survival advantage in intestinal stem cells as an important early event in the tumorigenic process.

PI_NAMEs: HEINEN, CHRISTOPHER D. (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Address;Adult;Affect;Alleles;Apoptosis;Biological Models;Cancer cell line;cancer therapy;Cell Cycle Arrest;Cell Cycle Checkpoint;Cell Death;cell growth;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;Colon Carcinoma;colonic crypt;Colorectal;Colorectal Cancer;CRISPR/Cas technology;Defect;Development;Diagnosis;Disease;DNA;DNA Damage;DNA Repair;DNA-Directed DNA Polymerase;Endometrial;Endowment;Environment;Epithelial Cells;Event;Experimental Models;Frequencies;gene repair;Genes;Goals;Growth;Hereditary Disease;Hereditary Nonpolyposis Colorectal Neoplasms;High Fat Diet;Human;human embryonic stem cell;human stem cells;in vivo;Inflammation;Inherited;insight;intestinal crypt;Intestines;Knock-out;knockout gene;Knockout Mice;Laboratories;lifetime risk;Malignant Neoplasms;Mediating;Mismatch Repair;Mismatch Repair Deficiency;MLH1 gene;Modeling;mosaic;mouse model;MSH2 gene;MSH6 gene;Mus;mutant;Mutation;novel;novel strategies;Oncogenes;Oncogenic;Organoids;Ovarian;oxidative damage;Pathway interactions;Patients;Penetrance;Phenotype;Play;PMS2 gene;pressure;prevent;Prevention;Prevention strategy;Process;Production;Regimen;repair function;response;Risk;Role;Sampling;stem cell model;stem cell niche;stem cells;Stress;System;Testing;Time;Tissue Sample;treatment strategy;tumor;Tumor Suppressor Proteins;tumorigenesis;tumorigenic

PROJECT_TITLE: The selective advantage of mismatch repair loss in colonic stem cells

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness;Substance Misuse

ORG_CITY: Princeton

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PRINCETON UNIVERSITY

PHR: Project Narrative. A critical faculty impaired in psychopathology is self-reflection: People’s capacity to reflect on the cognitive processes (thoughts, beliefs, desires, etc.) underlying their behavior. I use a novel, objective measure of this capacity – which assesses people’s accuracy when reflecting on how they’re making choices – to characterize variation in self-reflective accuracy across psychiatric symptom dimensions, and to test whether accuracy can be improved through a mindfulness intervention. This research provides a generative paradigm for studying self-reflection in choice, paving the way for future investigation into the neurocognitive mechanisms underlying self-reflection, its impairment, and its improvement.

PI_NAMEs: MORRIS, ADAM MITCHELL (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Age;Alcohol consumption;alcohol craving;alcohol cue;alcohol involvement;alcohol response;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Area;Attention;Behavior;Behavioral;Belief;Benchmarking;Brain;Clinical;Clinical Trials;Cognitive;cognitive process;Cognitive Science;Computer Models;Decision Making;diagnostic biomarker;Dimensions;Disease;Environment;Event;Faculty;Fellowship;follow-up;Funding;Future;Gender;General Population;Goals;Health;Home;Impairment;improved;Individual;Individual Differences;insight;Intervention;Investigation;Learning;Link;Location;Measures;Mediating;Mental Depression;Mental Processes;Mentors;Mentorship;mindfulness intervention;Mindfulness Training;Modeling;Neurocognitive;novel;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Participant;Patient Self-Report;Personal Satisfaction;Persons;Population;Process;psychiatric symptom;Psychiatry;Psychopathology;Race;Reporting;Research;Sampling;schizophrenia spectrum disorder;Self-reflection;Severities;social;Substance Use Disorder;Symptoms;Testing;Therapeutic Intervention;Thinking;Time;Training;Translating;United States National Institutes of Health;Variant;Weight;Work

PROJECT_TITLE: Self-reflective accuracy across subclinical dimensions of psychopathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Depression;Estrogen;Mental Health;Mental Illness;Neurosciences;Obesity;Osteoporosis;Pediatric;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Little is known about how pubertal blockade, the first step in the medical management of a young transgender adolescent, affects bone health and psychological well-being. The proposed project will explore how bone and mental health are impacted in these adolescents during pubertal blockade, and will examine the interplay between physical and psychological health. Our work will open new avenues for identifying preventive strategies to counter potential adverse effects of medical management on bone health in transgender adolescents, and will provide new information on the monitoring of both physical and mental health outcomes.

PI_NAMEs: DIVASTA, AMY D (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Address;Adipocytes;Adolescence;Adolescent;Adult;Adverse effects;Affect;Age;Agonist;Anxiety;assigned female at birth;assigned male at birth;Awareness;Beck depression inventory;Birth;Body mass index;bone;Bone Density;bone health;Bone Marrow;Bone Marrow Examination;bone mass;Bone structure;Child;Child Health;Clinical Assessment Tool;clinically relevant;clinically significant;cohort;critical period;Data;Development;Disease Progression;Distress;Dual-Energy X-Ray Absorptiometry;Eating Disorders;Equipment and supply inventories;Estrogens;Ethnic Origin;experience;Fatty acid glycerol esters;Feeling;Fracture;fracture risk;Gender;gender affirmation;gender dysphoria;Geometry;Goals;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;Health;health related quality of life;Hematopoietic;Hormonal;hormone therapy;Hormones;improved;insight;Intervention;Lipids;Long-Term Effects;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Marrow;Measurement;Measures;Medical;Mental Depression;Mental Health;Mesenchymal Stem Cells;Monitor;Obesity;Osteoblasts;Osteogenesis;Osteoporosis;Outcome;Participant;patient population;Patient Self-Report;Pediatric Hospitals;Peripheral;Phase;physical conditioning;Prevention strategy;Professional Organizations;Provider;Puberty;puberty blocker;Questionnaires;Race;Recommendation;recruit;Research;Research Personnel;restrictive eating;sex;Sex Characteristics;Site;skeletal;Skeleton;Spectrum Analysis;Structure;Testosterone;Time;tool;trait;transgender;Translating;Well in self;Work;X-Ray Computed Tomography;Yellow Marrow;Youth

PROJECT_TITLE: Skeletal Health and Bone Marrow Composition Among Youth

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE __ Unnecessary antibiotic exposure in newborns is common and has been associated with a variety of short- and long-term adverse outcomes. Antibiotic stewardship programs can safely and effectively reduce antibiotic exposure in the nursery setting, but most nurseries in rural or medically underserved areas lack the local expertise and support for nursery stewardship. Our study will test the widespread dissemination and implementation of a telehealth antibiotic stewardship program for rural nurseries that has been shown to be feasible, safe and effective.

PI_NAMEs: CANTEY, JOSEPH BENJAMIN (contact)

PROGRAM_OFFICER_NAME: MILLER, MELISSA

PROJECT_TITLE: Dissemination and implementation of a telehealth program to deliver effective antibiotic stewardship support to rural or medically underserved newborn nurseries.


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: TROY

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

ORG_STATE: NY

PHR: Project Narrative: The goal of this research is to develop and validate a comprehensive computer-based technology that will allow surgical trainees to practice their surgical skills on computer-based models. Surgical procedures and techniques, learnt and perfected in this risk-free manner before application to patients, will translate to fewer operating room errors, reduced patient morbidity and improved patient outcomes resulting in faster healing, shorter hospital stay and reduced post surgical complications and treatment costs.

PI_NAMEs: DE, SUVRANU  (contact);JACKSON, CULLEN DAVIS

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Adopted;Adoption;Adverse event;American College of Surgeons;Artificial Intelligence;Aviation;Awareness;Behavior;Board Certification;Boston;Client;Cloud Computing;cloud platform;cognitive skill;cognitive training;Communication;computer generated;Computer Models;Computers;conflict resolution;Consensus;Decision Making;Dedications;design;Discipline;distraction;Educational Curriculum;Educational process of instructing;Effectiveness;Environment;Evaluation;Event;experience;experimental study;Exposure to;eye hand coordination;Face;Faculty;Feedback;Floor;Goals;Grant;handheld mobile device;head mounted display;healing;improved;instructor;interactive computing;Internet;Interruption;Israel;Laparoscopic Cholecystectomy;Laparoscopic Surgical Procedures;Length of Stay;Machine Learning;Manikins;Medical center;member;Minimally Invasive Surgical Procedures;Modeling;Morbidity - disease rate;multidisciplinary;next generation;novel;Operating Rooms;Operative Surgical Procedures;Participant;participant enrollment;Patient-Focused Outcomes;Patients;Performance;Perioperative Nursing;Phase;Play;Process;programs;Protocols documentation;Reporting;Research;Resources;Risk;Running;Schedule;simulation;simulation environment;skills;skills training;Software Framework;Standardization;Stress;stressor;success;Surgeon;System;Technical Expertise;Techniques;Technology;Testing;Thinking;Time;Training;Training Activity;Translating;Treatment Cost;Variant;virtual;virtual environment;virtual patient;virtual reality;virtual reality environment;virtual surgery;Work

PROJECT_TITLE: Physically Realistic Virtual Surgery

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Microbiome;Rare Diseases;Urologic Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE The proposed study aims to comprehensively delineate the host-microbe mechanisms that modulate enteric hyperoxaluria within a complex host-microbe environment and determine the effect of oral antibiotics on that environment in humanized mice. Understanding oxalate metabolism at a systems level will provide novel opportunities for the development of bacteriotherapies to alleviate recurrent urinary stone disease (USD) that are tailored to individual patients. Considering the depth of interactions between oxalate and the gut microbiota as a whole, understanding how the microbiota regulates oxalate is highly significant and critical for the development of effective and persistent bacteriotherapies for recurrent USD.

PI_NAMEs: MILLER, AARON W (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: absorption;Acetates;Affect;Animal Model;Animals;Anti-Inflammatory Agents;Antibiotics;Bacteria;Calcium Oxalate;Carbon;Carbon Dioxide;Clinical;cohort;Complex;cytokine;Data;Development;dietary;Disease;Energy-Generating Resources;Enteral;Environment;Epithelial Cells;Excretory function;Exhibits;Exposure to;Formates;gut bacteria;gut microbiota;Hepatic;host-microbe interactions;Human;humanized mouse;hypercalciuria;Hyperoxaluria;IL8 gene;In Vitro;in vivo;Incidence;Individual;individual patient;Inflammation;Inflammatory;Inflammatory Response;Interleukin-1 beta;intestinal epithelium;Intestinal permeability;Kidney Diseases;Laboratories;Lead;Metabolic;Metabolism;Microbe;microbial;microbiome;microbiota;Molecular;novel;Oral;Oxalates;Oxalobacter formigenes;Patients;Play;Population;prevent;Prevention;Production;Proteins;Recording of previous events;Recurrence;remediation;renal epithelium;Risk;Rodent;Role;Series;sulfate reducing bacteria;System;Testing;Tight Junctions;Time;Toxic effect;United States;urinary;Urinary Calculi;Volatile Fatty Acids;Work

PROJECT_TITLE: The role of acetogenic, methanogenic, and sulfate-reducing bacteria in oxalate metabolism and hyperoxaluria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: AUGUSTA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Many neuro-degenerative/cognitive disorders manifest vascular impairments, including reduced functional hyperemia. However, isolating the impact of reduced functional hyperemia from other vascular changes is technically challenging. This proposal will harness a novel technique to block functional hyperemia independently from other vascular changes to determine the impact on neural function in health and in Alzheimer's disease.

PI_NAMEs: O'HERRON, PHILIP  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Action Potentials;Affect;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;APP-PS1;area striata;arteriole;Astrocytes;Biological Models;Biosensor;Blood flow;Blood Vessels;Brain;Brain Diseases;Brain region;Buffers;Calcium;cell cortex;Cells;Cerebrovascular Circulation;Cognition Disorders;Data;Dilator;Disease;Disease Progression;Electrodes;Electrophysiology (science);Equilibrium;excitatory neuron;extracellular;Fire - disasters;fluorescence imaging;Functional Imaging;Functional impairment;functional loss;Functional Magnetic Resonance Imaging;Glucose;Glycolysis;Health;Hyperemia;Image;imaging study;Imaging Techniques;Impairment;improved;Induced Neurons;information processing;inhibitory neuron;insight;Ions;Knock-out;Light;Literature;Location;Measures;Metabolic;Metabolism;Monitor;mouse model;Mus;Nerve Degeneration;neural;Neurodegenerative Disorders;neuronal metabolism;Neurons;Neurophysiology - biologic function;Neurosciences;neurovascular;neurovascular unit;novel;Nutrient;Opsin;optogenetics;orientation selectivity;Oxidative Phosphorylation;Oxygen;Pathology;pharmacologic;Phenotype;Physiological;Play;Property;Proxy;Reaction;reactive hyperemia;Regulation;response;Role;Running;Sensory;sensory stimulus;Signal Transduction;Smooth Muscle Myocytes;Stimulus;Techniques;Temperature;Testing;Tissues;two-photon;vasoconstriction;Vasodilation;visual stimulus;wasting

PROJECT_TITLE: Uncovering the physiological role of functional hyperemia

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]