NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Mental Health;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Sleep Research;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PHR: Project Narrative  The manner in which the brain responds to cumulative traumatic brain injuries (TBIs) and leads to neurological dysfunction is unknown. Our approach permits inter-injury in vivo microscopy to observe injury- induced change in blood flow and blood-brain barrier permeability, while recording post-traumatic sleep, as predictors of subacute neurological function. New insights to cumulative pathophysiology after TBI can inform clinical management and studies to reduce damage and accelerate recovery.

PI_NAMEs: LIFSHITZ, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acceleration;Activities of Daily Living;Acute;Affective;Anesthesia procedures;Anxiety;Automobile Driving;Behavior;Behavioral;Biomechanics;Blood flow;blood-brain barrier disruption;blood-brain barrier permeabilization;Blurred vision;Brain;Brain Concussion;care costs;Cephalic;Cerebrovascular Circulation;Chronic;Clinical;Clinical Management;Clinical Research;Closed head injuries;Cognitive;Data;Dextrans;Diagnosis;Disinhibition;Dizziness;Drops;Drowsiness;Emotional;executive function;Experimental Designs;Extravasation;Female;fluorescein isothiocyanate dextran;Fluorescence;fluorescence microscope;Functional disorder;Future;Head;head impact;Headache;healing;Health Care Costs;Helmet;Hyperalgesia;Image;imaging modality;Immune;Impairment;in vivo;in vivo imaging;Individual;Injury;insight;Intensive Care;Intervention;intraperitoneal;Investigation;Learning;Location;male;Measures;Mechanics;Memory;Mental Depression;Microscope;Microscopy;mild traumatic brain injury;miniaturize;Modeling;Molecular Weight;Monitor;multimodality;Mus;Nervous System Physiology;neural;neurobehavior;neurobehavioral;neurochemistry;Neurologic;Neurologic Dysfunctions;Neurological outcome;neurophysiology;novel;Outcome;Pain;Pathology;Patients;Performance;Permeability;Persons;Phenotype;Physiological;Physiology;Polysomnography;Post-Concussion Syndrome;pre-clinical;pressure;Procedures;Prognosis;prospective;Quality of life;Recovery;Reporting;response;restraint;Risk;Risk Assessment;Rodent;Rotation;sensor;Sensory;Severities;Sleep;Sleep Disorders;Sleeplessness;societal costs;somatosensory;spatial memory;Speed;Symptoms;Techniques;Technology;Testing;Therapeutic Intervention;Time;timeline;Tracer;Traumatic Brain Injury;United States;Vasodilation;Visualization;Weight;Width

PROJECT_TITLE: Miniscope in vivo imaging of cumulative traumatic brain injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Data Science;Genetics;Human Genome;Neurosciences

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTOLARYNGOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE The gene Expression Analysis Resource (gEAR portal, umgear.org) is a cloud-based tool for analysis, visualization and sharing of multi-species multi-omic inner-ear related data. It serves to bridge the gap between the breadth, depth and complexity of high throughput multi-modality omics data and the biologists, which are often not trained in programming, yet require meaningful and rapid access to these data for their work. Completion of the proposed gEAR advancements will catalyze basic science discovery and advance development of therapeutics for hearing and balance disorders.

PI_NAMEs: MAHURKAR, ANUP  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acceleration;Address;Adult;Advanced Development;analytical tool;ATAC-seq;Atlases;Basic Science;Bioinformatics;Biological;Biological Sciences;BRAIN initiative;Categories;cell type;Cells;cloud based;Cochlea;Communities;Complex Analysis;Data;Data Discovery;data dissemination;data mining;Data Set;data sharing;data warehouse;Dedications;Development;Ear;Education and Outreach;Educational workshop;Engineering;Environment;Epigenetic Process;epigenomics;equilibration disorder;Equilibrium;experience;Feedback;Fostering;Future;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Generations;Goals;Hearing;Hearing problem;improved;Infrastructure;inner ear development;insight;Instruction;Laboratories;Labyrinth;Libraries;Manuals;Manuscripts;Maps;member;multidisciplinary;multimodality;Multiomic Data;multiple omics;Mus;Names;operation;Organ;Organizational Models;Performance;Persons;public database;Public Domains;Publications;Research;Research Personnel;Resolution;Resources;scaffold;Scientist;single-cell RNA sequencing;skills;Structure;Surgeon;Surveys;Technology;therapeutic development;tool;Training;transcriptomics;translational therapeutics;Update;Validation;Visit;Visualization;webinar;Work

PROJECT_TITLE: The gEAR portal - Advancing Data Sharing, Analysis and Discovery for Hearing and Balance Research

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The biggest obstacles to HIV cure include the vast heterogeneity and resistance to killing of the HIV reservoir. We have designed a strategy that has the potential of overcoming both these obstacles, while enhancing immune responses and combined it with a revolutionary technique that allows us to dissect the mechanisms of viral reservoir and clarify the therapeutic potential of our strategy in the tissues of living macaques used as model of HIV infection.

PI_NAMEs: MARTINELLI, ELENA  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Ablation;Animals;anti-PD-1;antiretroviral therapy;Apoptosis;Apoptotic;Area;Autopsy;BCL1 Oncogene;Binding;Biological Assay;Bypass;CD28 gene;CD4 Positive T Lymphocytes;Cell Death;Cell model;Cell Separation;Cells;Cellular Metabolic Process;Combined Modality Therapy;Control Groups;Critical Pathways;Data;Dependence;design;Development;Disease;DNA;Effector Cell;Ensure;Event;falls;Flow Cytometry;Frequencies;Gastrointestinal tract structure;Genetic Transcription;Heterogeneity;HIV;HIV Infections;Immune;immune function;Immune response;Immunity;Immunologic Suppressor Factors;ImmunoPET;Immunosuppression;In Vitro;in vitro Model;in vivo;in vivo evaluation;Individual;Infection;inhibitor;innovation;Interruption;Intrinsic factor;Investigation;Kinetics;long term memory;lymph nodes;Macaca;Maintenance;Measures;Mediating;Memory;Metabolic;metabolomics;Methods;Microscopy;Modeling;multidisciplinary;Nature;Nivolumab;Noise;novel;novel strategies;Pathway interactions;PD-1 blockade;PET/CT scan;Pharmaceutical Preparations;Phenotype;Positron-Emission Tomography;Predisposition;pro-apoptotic protein;programmed cell death protein 1;programs;Property;Proteomics;Proviruses;reactivation from latency;Receptors, Adrenergic, beta-1;Resistance;response;Rest;Rhesus;Sampling;Signal Transduction;Site;SIV;Sleep;small molecule inhibitor;spatiotemporal;Stimulus;Systems Biology;T memory cell;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;Tissue Sample;Tissues;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Viral;viral rebound;Viral reservoir;Virus

PROJECT_TITLE: Turning off HIV White Noise: Switching from Long-Lived to Short-Lived Reservoir


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: The goal of this research is to better understand the impact of aging on the DNA of individual cells in people with and without Alzheimer’s disease (AD). Our lab has recently discovered that human brain cells continually accumulate mutations throughout life, a phenomenon called genosenium, and that the rate that mutations accumulate is much higher in individuals with AD. We will further explore this event in different regions of the brain and in different cell types in order to elucidate the underlying mechanisms at work, and explore how they are related to AD.

PI_NAMEs: LEE, EUNJUNG ALICE;WALSH, CHRISTOPHER A. (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Acceleration;Age;age related;aged;Aging;Alzheimer's Disease;Alzheimer's disease brain;Area;Astrocytes;Autopsy;Birth;Brain;brain cell;brain control;Brain Diseases;Brain Neoplasms;Brain region;caudate nucleus;Cell division;cell type;Cells;Classification;Cognitive aging;Data;dentate gyrus;design;Disease;disorder risk;DNA;DNA sequencing;Elderly;entorhinal cortex;Event;examination questions;Freezing;Genome;genome sequencing;genome-wide;genome-wide analysis;genotoxicity;Glioma;Goals;Health;Hippocampus;Human;human old age (65+);Individual;insight;Life;Methods;Microglia;Molecular;Motor Cortex;Mutation;Neonatal;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neuronal Dysfunction;neuronal metabolism;Neurons;normal aging;Oligodendroglia;oxidative damage;Pathologic Mutagenesis;Pattern;Persons;postmitotic;Prefrontal Cortex;Process;Research;Single Nucleotide Polymorphism;Somatic Mutation;stem cells;tau Proteins;tau-1;Techniques;technological innovation;Testing;therapy development;Time;tool;Variant;whole genome;Work

PROJECT_TITLE: Rates and mechanisms of age-related somatic mutation in normal and Alzheimer brain


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Neuronal remodeling is a conserved process whereby the developing nervous system eliminates extraneous cells and connections. This refinement allows for proper rewiring of the nervous system for optimal function in adulthood. My goal is to understand the fundamental mechanisms by which unneeded neurons and connections are recognized and appropriately eliminated from the developing nervous system, which holds promise for furthering our understanding of neurodevelopmental disorders such as Autism Spectrum Disorders and Schizophrenia.

PI_NAMEs: DE LA TORRE, RACHEL YVETTE (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Adult;Animals;Apoptosis;Astrocytes;autism spectrum disorder;Axon;Biological Assay;Biological Metamorphosis;Biological Models;Cell Compartmentation;Cell Surface Receptors;cell type;Cells;Central Nervous System;Cessation of life;Data;Defect;Development;Drosophila genus;Excision;Exclusion;Failure;fly;Genes;Genetic;Goals;Human;human disease;Immunoglobulins;in vivo;Individual;Inflammation;insight;Integral Membrane Protein;knock-down;Knock-out;Knowledge;Larva;Mammals;Mediating;Membrane;Methods;Modeling;Molecular;Names;Nature;Nervous System;Neurites;Neurodevelopmental Disorder;Neuroglia;neuronal cell body;neuronal circuitry;Neurons;Neuropil;neurotransmission;novel;Pathway interactions;Phagocytes;Phagocytosis;Process;Proteins;receptor;Research;response;RNA Interference;Role;Schizophrenia;sensory input;Signal Transduction;Specific qualifier value;Specificity;Stereotyping;Synapses;System;Testing;tool;transcriptomic profiling;Turtles;Visual System;Visualization;Work

PROJECT_TITLE: How do glia remodel the nervous system?


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Precision Medicine

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Anxiety-, obsessive-compulsive and trauma- and stressor-related disorders reflect a significant public health problem. This study is designed to evaluate the predictive power of a novel biomarker based on a CO2 challenge, thus addressing the central question “can this easy-to-administer assay aid clinicians in deciding whether or not to initiate exposure-based therapy?”

PI_NAMEs: OTTO, MICHAEL W. (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Address;Adult;Aftercare;Algorithms;Animals;Anxiety;Anxiety Disorders;anxiety treatment;anxiety-related disorders;Area;Basic Science;Benchmarking;Biological Assay;Biological Markers;biomarker identification;biomarker performance;biomarker selection;Boston;Carbon Dioxide;Classification;Clinic;Clinical;Clinical assessments;clinical practice;Data;design;Development;Diagnosis;Diagnostic;Disease;Disease remission;DSM-V;effective therapy;Elements;Enrollment;Exposure to;Extinction;follow-up;Fright;Future;Genotype;Goals;Human Resources;Hypercapnia;Hyperventilation;hypocretin;Impairment;improved;indexing;Intervention;Investigation;Link;Measures;Mediating;meetings;Middle Hypothalamus;Modeling;National Institute of Mental Health;Neurons;novel marker;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Panic Disorder;Participant;Patients;personalized medicine;Phenotype;Plasma;Post-Traumatic Stress Disorders;Prediction of Response to Therapy;predictive modeling;Predictive Value;Procedures;productivity loss;prognostic;prospective;Protocols documentation;Proxy;Public Health;Rattus;receptor;Recovery;Research;Resources;respiratory challenge;response;ROC Curve;Rodent;Role;Saliva;Sample Size;Sampling;Selection for Treatments;Severities;Signal Transduction;Site;sound;Specificity;Speed;Strategic Planning;stressor;Structure;Symptoms;System;Testing;Translating;translation to humans;Translations;Trauma;Treatment Cost;treatment strategy;Work

PROJECT_TITLE: 2/2-CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_NAME: SIMMERSION, LLC.

PHR: PROJECT NARRATIVE Transition-age youth with Autism Spectrum Disorders (ASD) experience high rates of unemployment and underemployment, in substantial part due to deficits in social cognition. Social Cognitive and Affective Learning at Work (SOCIAL-Work) will be a school-delivered, interactive, computer-based training system featuring work-place choices and conversations that allow transition-age youth with ASD to practice, apply, and translate the social cognitive skills necessary to improve their ability to sustain employment.

PI_NAMEs: OLSEN, DALE EDWARD (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: 3-Dimensional;active control;Address;Administrator;adolescent with autism spectrum disorder;Adoption;Adult;Affective;Age;aged;Anxiety;anxiety reduction;attentional control;Cognitive;cognitive ability;Cognitive deficits;cognitive skill;cognitive task;commercialization;Communication;Communities;community advisory board;community based participatory research;Community Services;computerized;Computers;Control Groups;Cues;Data;design;Development;disability;E-learning;Education;Educational Curriculum;effectiveness testing;effectiveness-implementation RCT;effectiveness/implementation trial;efficacy testing;Emotions;Employment;Enrollment;Environment;Evidence based practice;experience;Family;Feedback;fictional works;Focus Groups;follow-up;Goals;group intervention;health care availability;health economics;high school;implementation evaluation;improved;Individual;individuals with autism spectrum disorder;innovation;Instruction;Intervention;Interview;Knowledge;knowledge integration;Learning;Life;Mediating;Mental Health;Methods;Michigan;Modeling;North Carolina;novel;Occupations;Outcome;Participant;peer;peer coaching;Persons;Phase;physical conditioning;Process;process evaluation;programs;prototype;Psyche structure;Randomized;Reading;recruit;Reporting;Research;Research Methodology;Research Personnel;Sales;Sampling;scaffold;Schools;service providers;Services;skills;social;social cognition;Social Functioning;Social Planning;social skills;System;Task Performances;teacher;Technology;Testing;tool;Training;Translating;treatment effect;Underemployment;Unemployment;usability;virtual;Work;working group;Workplace;Youth

PROJECT_TITLE: Applied Social Cognitive Skills in the Workplace for Transition-Aged Youth with Autism Spectrum Disorder


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative This project is aimed at developing a novel combination liposomal nanotherapeutic platform for effective co- delivery of immunogenic chemotherapeutics and inhibitors targeting IDO1 to enhance the efficacy of PD-L1/PD- 1 blockade therapy. Successful completion of this study may lead to the development of an innovative combined immunochemotherapy nanoplatform to potentiate the immune checkpoint blockade therapy for improved treatment of various types of cancers including colorectal cancer.

PI_NAMEs: LU, JIANQIN  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: amphiphilicity;anti-cancer;Antineoplastic Agents;antitumor effect;Blood Circulation;Blood Circulation Time;Camptothecin;cancer cell;Cancer Etiology;Cancer Model;Cancer Patient;cancer therapy;cancer type;Cells;Cessation of life;Charge;chemotherapy;Clinic;Clinical;clinical application;Clinical Trials;colon cancer patients;Colorectal Cancer;Combined Modality Therapy;Cytotoxic T-Lymphocytes;Development;Disulfides;Doxorubicin;Doxorubicin Hydrochloride Liposome;Drug Kinetics;Drug Modelings;effector T cell;Encapsulated;Fortification;Goals;Hydrophobicity;hydroxyl group;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immunity;Immuno-Chemotherapy;Immunocompetent;immunogenic;immunogenic cell death;Immunosuppression;improved;In Vitro;in vivo;inhibitor;innovation;Interferon Type II;Kinetics;Lactones;Length;Lipid Bilayers;liposomal delivery;Liposomes;Maximum Tolerated Dose;Measures;Mediating;Memory;Microsatellite Instability;Mismatch Repair Deficiency;Monoclonal Antibodies;Mus;nanotechnology platform;nanotherapeutic;novel;Pathway interactions;Patients;PD-1 blockade;PD-1 inhibitors;PD-1/PD-L1;Pharmaceutical Preparations;Phospholipids;pi bond;Regimen;Regulatory T-Lymphocyte;response;Safety;screening;Secure;self assembly;Series;side effect;Solubility;standard of care;Structure-Activity Relationship;success;System;systemic toxicity;T-Cell Proliferation;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic Agents;Tissues;Toxic effect;Translating;Transportation;Treatment Efficacy;Tryptophan;Tryptophan 2,3 Dioxygenase;tumor;tumor eradication;Tumor Immunity;Up-Regulation;uptake;Vertebral column

PROJECT_TITLE: A Phospholipid-Derived Nanotherapeutic Platform for Improved Colorectal Cancer Immunochemotherapy

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Narrative: This proposal seeks to address long-standing racial and ethnic disparities in use of permanent contraception (historically called “surgical sterilization”) by disseminating PCOR on the comparative safety and effectiveness of long-acting contraceptives. Although permanent contraception aligns well with some patients’ reproductive life plans, reports that 10% of women regret having undergone these procedures are troubling. By increasing equitable access to alternatives to permanent contraception, this project strives to increase the proportion of US women who are using a method of contraception that aligns with their personal preferences and reduce the proportion of individuals who regret having undergone a permanent contraceptive procedure.

PI_NAMEs: SCHWARZ, ELEANOR BIMLA (contact)

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: Disseminating PCOR findings to Reduce Racial Disparities in Surgical Sterilization


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: STONY BROOK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: 8. PROJECT NARRATIVE Chromatin structure and organization profoundly influence gene expression which ultimately controls normal cell proliferation and cellular differentiation in humans. Mutations in genes functioning in chromatin assembly and remodeling are found associated with numerous human tumors. This grant is focused on understanding a unique type of chromatin structure and how this structure is used by the cell to influence genomic activities, such as gene expression. The outcome of this research could potentially lead to new targets for therapeutic intervention.

PI_NAMEs: LUK, EDWARD E (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: adduct;Affect;Affinity;Antibodies;Arginine;Binding;Biochemical;Biological;Biological Process;Biology;Biophysics;Cancer Biology;Cell Differentiation process;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Chemicals;Chromatin;Chromatin Fiber;Chromatin Modeling;chromatin remodeling;Chromatin Structure;Collaborations;crosslink;Cryoelectron Microscopy;Cysteine;Data;Data Set;dimer;Dimerization;DNA;Electron Microscopy;Eukaryota;Eukaryotic Cell;Gene Expression;gene function;Gene Silencing;Genes;Genetic;Genetic Transcription;Genome;Genomics;Grant;Heterochromatin;Histone H2A;Histone H3;Histone H4;Histones;Human;In Vitro;in vivo;insight;Left;Length;Link;Maintenance;Malignant Neoplasms;Maps;Methodology;Minor;Modification;Molecular;Molecular Conformation;Mutagenesis;mutant;Mutation;N-terminal;Nature;Negative Staining;new therapeutic target;Normal Cell;novel;Nuclear;Nuclease Protection Assays;Nucleoproteins;Nucleosomes;Outcomes Research;Paper;particle;Positioning Attribute;Productivity;Property;Publishing;Recombinants;reconstitution;Resolution;Role;Saccharomyces cerevisiae;Sedimentation process;Shapes;Site;stoichiometry;Structure;telomere;Testing;Therapeutic Intervention;tumor;tumor progression;Variant;Yeasts

PROJECT_TITLE: Uncovering the biomolecular function of the R-octasome--a nucleosome-like particle with only H3 and H4 histones

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Precision Medicine;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Recent discoveries in cancer research have revealed that many aggressive cancers consume glutamine to fend off toxic reactive oxygen species in addition to using glutamine to produce energy and building blocks for making more cells. We will develop positron emission tomography (PET) imaging methods to report the glutamine metabolism level and glutamate transport activity in triple-negative breast cancers to guide targeted therapy. Once they are validated in animal models of this proposal, these imaging tools can be readily translated to the clinic for personalized treatment based on specific cancer metabolic features for each patient.

PI_NAMEs: MANKOFF, DAVID A. (contact);ZHOU, RONG

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: alpha ketoglutarate;Amino Acids;Anabolism;analog;Animal Model;anti-cancer research;antiporter;Biological Markers;biomarker performance;biomarker validation;Breast;Breast Cancer Cell;Breast Cancer Model;cancer cell;cancer clinical trial;Catabolism;cell growth;Cell membrane;Cells;chemotherapy;Cisplatin;Citric Acid Cycle;Clinic;Clinical Markers;Clinical Trials;Consumption;Data;Dependence;Enzymes;Exposure to;Extracellular Fluid;FDA approved;genetic signature;Glutamate Transporter;Glutamates;Glutamic Acid;Glutaminase;Glutamine;Glutathione;Growth;Homeostasis;Human;imaging agent;imaging biomarker;Imaging Device;imaging modality;Immunotherapy;inhibitor;Intervention;Kinetics;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;Methodology;Methods;Mitochondria;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Paclitaxel;Pathway interactions;patient derived xenograft model;Patient imaging;Patient Selection;Patient-derived xenograft models of breast cancer;Patients;Pattern;personalized medicine;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;Play;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;predicting response;predictive marker;preservation;Production;quantitative imaging;rapid growth;Reactive Oxygen Species;refractory cancer;Reporting;Resistance;response;Role;targeted treatment;Testing;Therapeutic;therapy design;Toxic effect;Tracer;Translating;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;Work;Xenograft Model

PROJECT_TITLE: PET Imaging of Glutamine Metabolism and Glutamate Transport to Guide Metabolically Targeted Therapy in Triple-Negative Breast Cancer

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Preterm, Low Birth Weight and Health of the Newborn;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Unintentional Childhood Injury

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Preterm infants are at risk of bleeding in the brain which can cause permanent damage and long-term disabilities for which no treatment exists. We discovered that fibrinogen, a blood clotting protein, leaks into the injured brain and blocks stem cells from forming the new neurons and myelin needed for normal brain development. The goal of this project is to determine if we can overcome fibrinogen’s inhibitory effects in the brain as a new treatment strategy for preterm infant brain injury.

PI_NAMEs: PETERSEN, MARK A (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: activin A;Adult;Alzheimer's Disease;Animal Model;Attenuated;Binding;Binding Sites;Blocking Antibodies;Blood - brain barrier anatomy;Blood coagulation;Blood Proteins;Blood Vessels;blood-brain barrier disruption;bone morphogenetic protein receptor type I;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;Brain;Brain hemorrhage;Brain Injuries;Cell Maturation;Cells;Central Nervous System;Cerebellum;Cicatrix;clinically relevant;Coagulation Process;Congenital cerebellar hypoplasia;Cytoplasmic Granules;Data;defined contribution;Deposition;Development;Developmental Disabilities;Disease;efficacy evaluation;Environment;Fibrin;Fibrinogen;Fibrinogen Receptors;Functional disorder;Genetic;Goals;Growth;Hemorrhage;Human;human disease;human induced pluripotent stem cells;immune activation;Impairment;improved;in vivo;induced pluripotent stem cell;infant brain injury;Inflammation;Inflammatory;inhibitor;Injections;Injury;Innate Immune Response;Integrins;ITGAM gene;ITGB2 gene;Knock-in Mouse;Link;Lipopolysaccharides;Long term disability;Macrophage;Microglia;Modeling;Molecular;Molecular Profiling;Monoclonal Antibodies;Multiple Sclerosis;Mutant Strains Mice;Mutate;Myelin;Natural regeneration;Neonatal;neonatal mice;Nerve Degeneration;nerve stem cell;nervous system development;Nervous System Disorder;Neurodevelopmental Impairment;neurogenesis;neuroinflammation;Neurons;neurovascular;novel;novel therapeutic intervention;Organoids;Outcome;Oxidative Stress;Pathway interactions;pharmacologic;Plasma;Premature Infant;preservation;prevent;Proteins;Reactive Oxygen Species;receptor;Receptor Signaling;remyelination;repaired;Risk;Role;Signal Transduction;Signaling Protein;small molecule inhibitor;stem cell fate;stem cell population;stem cell proliferation;stem cells;systemic inflammatory response;Testing;Therapeutic;transcriptomics;Trauma;Traumatic injury;Treatment Efficacy;Work

PROJECT_TITLE: Overcoming the Inhibitory Neurovascular Niche in Preterm Infant Brain Injury

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Infectious Diseases;Lung;Nanotechnology;Pneumonia;Pneumonia and Influenza

PHR: Respiratory infections including COVID19 ignite the host response in the lungs. Endothelial cells in the pulmonary vasculature mediate recruitment of neutrophils to fight the invaders. Neutrophils inflict the collateral damage to endothelium. Emerging clinical reports implicate this complication in poor outcomes of COVID19 in the high-risk patients. We have devised nanocarriers for targeted delivery of protective agents to endothelium using ligand molecules with specific affinity to these cells. In the pilot studies we have also found that some nanocarriers lacking affinity ligands fortuitously accumulate on the neutrophils residing in the pulmonary vasculature. Using these two types of nanocarriers may permit cell-specific delivery of distinct drugs to endothelium vs neutrophils. Dual drug delivery of distinct pharmacological interventions in these adjacent cells may enable alleviation of the endothelial collateral damage concomitantly with desirable modulation of neutrophil activity. In this project, we will devise these dual drug delivery system(s), characterize their mechanism of action and appraise their benefit/risk ratio in pre-clinical translational studies in animal models of respiratory infection.

PI_NAMEs: MUZYKANTOV, VLADIMIR R (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Affinity;airway epithelium;Alveolar;alveolar epithelium;Animal Model;Anti-Inflammatory Agents;Anti-viral Agents;Antibiotics;Antibodies;Antioxidants;Bacteria;Bacterial Pneumonia;Binding;Blood;Blood capillaries;Blood Vessels;Bypass;cell type;Cells;Cessation of life;Clinical;combat;Complement;Complement 3b;Complication;Conjugated Carrier;COVID-19;Cryoelectron Microscopy;cytokine;Data;Drug Delivery Systems;Drug Kinetics;Drug Side Effects;Drug Targeting;Endothelial Cells;Endothelium;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Epitopes;fighting;Fire - disasters;Flow Cytometry;Formulation;Friends;high risk;Histology;Host Defense;Human;Immune response;Immunosuppression;In Vitro;in vivo;Individual;Infection;infection risk;Inflammatory;Injections;Intervention;Invaded;Klebsiella pneumoniae;lead candidate;Leukocytes;Ligand Binding;Ligands;Liposomes;Liquid substance;Lung;lung injury;Mass Spectrum Analysis;Mediating;Mediator;Membrane Proteins;Microbe;microbial;microcalorimetry;Microscopy;monolayer;mouse model;Multiple Organ Failure;Mus;nanocarrier;nanoformulation;nanoparticle;nanoscale;neutrophil;Neutrophil Infiltration;Opsonin;Organ;Outcome;Patients;Pattern;Perfusion;Phagocytosis;Pharmaceutical Preparations;pharmacologic;Phase;Pilot Projects;Plasma;Play;Pneumonia;pneumonia treatment;Poison;pre-clinical;prevent;Property;Protective Agents;Publishing;Pulmonary Inflammation;Reactive Oxygen Species;recruit;Reporting;Respiratory Tract Infections;risk/benefit ratio;Roentgen Rays;Scanning;screening;secondary infection;Secondary to;Serum;Site;Sterility;Surface;System;targeted delivery;Testing;Tissues;translational study;Tropism;uptake;Variant;Viral;Viral Pneumonia;Virus

PROJECT_TITLE: Dual drug delivery to lung/blood interface in respiratory infections.

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Digestive Diseases;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative: Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in the newborn period. NEC happens when tissue in the small or large intestine is injured or begins to die off. This proposal will investigate how to prevent this disease and will develop new treatments.

PI_NAMEs: CHAABAN, HALA  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 3-Phosphoinositide Dependent Protein Kinase-1;Acceleration;Adult;Affect;Attenuated;Bacterial Infections;Bacterial Translocation;Cell Count;Cessation of life;Colitis;Colostrum;Complex;conditional knockout;Data;Development;dietary supplements;Disease;Dithizone;dysbiosis;Emergency Situation;Enteral;Enterocytes;Epithelial Cells;epithelial injury;epithelial repair;Epithelium;epithelium regeneration;Family;feeding;FRAP1 gene;gastrointestinal;genetic approach;Glycosaminoglycans;Goals;Goblet Cells;gut inflammation;Homeostasis;Human;Human Milk;Hyaluronan;Hypoxia;Immunohistochemistry;Impairment;Infant;Inflammation;injured;Injury;insight;Intervention;intestinal barrier;intestinal epithelium;intestinal homeostasis;intestinal injury;intestinal maturation;Intestinal permeability;Intestines;Invaded;kinase inhibitor;Klebsiella Infections;Knockout Mice;Lactation;Large Intestine;Literature;Measures;Mediating;member;Modeling;mortality;mouse model;Mucous Membrane;Multiple Organ Failure;Mus;Natural regeneration;Necrosis;Necrotizing Enterocolitis;Newborn Infant;novel;novel strategies;Oral;Oral Administration;Paneth Cells;Pathogenesis;Pathology;Pathway interactions;pharmacologic;Phosphotransferases;PIK3CG gene;Play;postnatal;premature;Premature Infant;prevent;Prevention;Prevention strategy;Preventive therapy;Proliferating;protective effect;Protein-Serine-Threonine Kinases;Proteins;Proto-Oncogene Proteins c-akt;pup;Radiation Injuries;Regenerative capacity;Risk;Role;Scientist;Severities;Signal Pathway;Signal Transduction;Sirolimus;Small Intestines;stem cells;systemic inflammatory response;Testing;Therapeutic;Tight Junctions;Tissues;transcriptome sequencing;TSC1 gene;Western Blotting;wound healing

PROJECT_TITLE: Prevention of Necrotizing Enterocolitis

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Infectious Diseases;Lung

ORG_CITY: TYLER

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Infectious respiratory diseases such as those caused by nontuberculous mycobacteria (NTM) are acquired through environmental exposures that remain largely under-described. Every day, millions of people inhale hazardous aerosol emissions from erupting volcanoes globally; our evidence supports NTM are hitchhikers on volcanic ash that together overcome innate immune control by lung cells to establish infection. In this proposal, microbiological, molecular, and immunological assays and human lung cells from healthy donors will be studied to reveal the immunological mechanisms of front-line lung cells to NTM and volcanic ash, providing critical new information to improve respiratory health.

PI_NAMEs: HONDA, JENNIFER R. (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: 3-Dimensional;Aerosols;Air;airway epithelium;Alveolar Macrophages;Antimycobacterial Agents;Apical;Automobile Driving;Behavioral;Binding;Biochemical;Biological;Biological Assay;Cell model;Cells;Chimera organism;Chronic;Collection;Coughing;Data;Defense Mechanisms;Development;Disease;Dust;Elements;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Epithelial Cells;Exposure to;Financial cost;fitness;Frustration;Genetic;genome sequencing;Genomics;Genus Mycobacterium;Geographic Locations;Geography;Goals;Growth;Hawaii;Health Hazards;Hot Spot;Household;Human;imaging study;Immune;Immune response;Immunologic Factors;Immunologics;Immunology procedure;Impairment;improved;In Vitro;Individual;Infection;Inflammasome;Inhalation;innate immune mechanisms;Innate Immune Response;innovation;irritation;Island;Knowledge;Liquid substance;Lung;Lung Diseases;Lung infections;Macrophage;Mediating;Microbial Biofilms;Molecular;Mycobacterium abscessus;Mycobacterium avium;Mycobacterium Infections;non-tuberculosis mycobacteria;opportunistic pathogen;Organism;Organoids;Outcome;particle;Particulate;pathogen;Pathogenesis;Pathway interactions;Persons;Planet Earth;pollutant;Predisposition;Prevalence;Prevention;Public Health;Recovery;Refractory;Relapse;Reporting;Research;Research Personnel;respiratory;Respiratory Disease;respiratory health;Respiratory Tract Infections;response;Risk Assessment;Role;Sampling;Soil;Surface;System;Testing;Therapeutic Intervention;transmission process;Tuberculosis;Uncertainty;United States;Virulence Factors;Volcanic Ash;volcano;Water;whole genome;Work

PROJECT_TITLE: Distinct responses of lung macrophages and airway epithelial cells to Hawai'i-derived volcanic ash and nontuberculous mycobacteria

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Caregiving Research;Clinical Research;Heart Disease;Palliative Care

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The health risks related to heart failure (HF) – the fastest growing cardiovascular disorder – are particularly grave for America's expanding population of older adults, for whom HF is the primary reason for hospitalization, and who experience the highest burden of serious adverse outcomes related to HF hospitalization (re-admission and death). HF hospitalization also poses serious health risks for family caregivers, particularly spouses/partners, who are critical to patients' successful post-discharge transition to home, but not without substantial cost to their own health and well-being (increased strain, mortality risk). This proposal employs innovative methods to advance our understanding of how older hospitalized HF patients and spouse/partner caregivers monitor and respond to HF symptoms together during the post-discharge period, and how dyadic symptom monitoring and clinical biomarkers of HF progression can enhance our knowledge of mechanisms of risk, and uncover potential targets for precision interventions to support patient, caregiver, and dyad health.

PI_NAMEs: BIDWELL, JULIE THERESA (contact)

PROGRAM_OFFICER_NAME: AKUBU-ODERO, MAUREEN KALAMBU

PROJECT_TERMS: Address;adverse outcome;Affect;Age;Aging;aging population;Agreement;associated symptom;Award;Biological Markers;biomarker identification;Cardiovascular Diseases;care seeking;career development;caregiver strain;Caregivers;caregiving;Caring;Center for Translational Science Activities;Cessation of life;Characteristics;Clinical;clinical biomarkers;Clinical Markers;Clinical Sciences;Cognition;Communication;cost;Coupled;Couples;Data;diaries;Dyspnea;Educational workshop;Elderly;Enrollment;Environment;Event;experience;Family;Family Caregiver;Fatigue;Foundations;Funding;Future;Goals;Health;Health Promotion;Health Status;Heart failure;high risk;Home;hospital readmission;Hospitalization;Immersion;Impairment;improved;Incidence;Individual;innovation;insight;Institution;Intervention;Knowledge;longitudinal analysis;longitudinal design;loved ones;member;Mentors;Methods;Modeling;Monitor;mortality risk;older adult;Older Population;Outcome;Patient-Focused Outcomes;Patients;Pattern;Perception;person centered;Personal Satisfaction;personalized intervention;Play;poor health outcome;Population;primary outcome;Process;programs;Public Health;Quality of life;Reporting;Research;Resources;response;Risk;Risk Assessment;Risk Estimate;Role;secondary outcome;Serum;Severities;skills;Spouses;symptom management;Symptoms;Testing;theories;Time;Training;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: The Symmetry-HF Study: Symptom Dynamics and Clinical Biomarkers of Heart Failure in Older Adult Care Dyads After Heart Failure Hospitalization

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(82)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: SEATTLE

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE As older adults with Alzheimer’s disease and related dementias (ADRD) decline, they are increasingly omitted from decisions regarding care. The goal of this research is to keep older adults with dementia involved in decision-making through better understanding their decision-making processes and creating a novel tool to identify preferences related to transitions in care.

PI_NAMEs: TURNER, ANNE M (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Admission activity;Adult;Age;Alzheimer's disease related dementia;Assisted Living Facilities;care preference;care providers;Caregiver Burden;Caregivers;Caring;cost;Decision Making;Dementia;dementia care;design;Discipline of Nursing;Disease;Exclusion;experimental study;Goals;Health;Health care facility;Home;human centered design;Impaired cognition;Impairment;Independent Living;Individual;innovation;Interview;Long-Term Care;Longitudinal cohort;memory care;Methodology;Methods;Modeling;novel;novel strategies;Nursing Homes;older adult;person centered;Personhood;Persons;Population;preference;Process;programs;Quality of life;Research;Safety;social;sound;Source;supportive environment;Time;tool;United States;Visual;Visualization;Well in self

PROJECT_TITLE: Person-centered decision making: Developing a choice-based preference tool for transitions in dementia care

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ADMINISTERING_IC: DK

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Kidney Disease;Liver Disease;Nutrition;Obesity

ORG_CITY: Nashville

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative The consequences of overnutrition on human health are perilous, even though the prevalence of metabolic disease in adults is so high that it may constitute a new normal. The goal of this project is to develop a clearer understanding of the metabolic features that influence glucose production and da mage in the kidney and liver during obesity so that they may be better targeted to reduce the burden of disease. This proposal incorporates a significant training and development plan aimed at shifting my career toward research independence.

PI_NAMEs: HASENOUR, CLINTON MICHAEL (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acceleration;Adult;Biological Models;burden of illness;career;career development;Cell Respiration;Chronic;Chronic Kidney Failure;Citric Acid Cycle;clinically relevant;Continuity of Patient Care;counterregulation;Coupled;Data;Development;Development Plans;Diabetes Mellitus;Diabetic Nephropathy;dietary;Dietary Intervention;Disease;Disease Progression;Ensure;Etiology;euglycemia;Exhibits;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;Foundations;Genetic;Gluconeogenesis;Glucose;glucose metabolism;glucose production;glycemic control;Goals;Health;Hepatic;Human;Hypoglycemia;Impairment;improved;in vivo;Inflammation;inhibitor;innovation;insight;Intervention;Kidney;kidney metabolism;Knock-out;Knowledge;lens;Link;Lipids;Liver;liver injury;liver metabolism;Mediating;member;Mentors;Metabolic;metabolic abnormality assessment;Metabolic Control;Metabolic Diseases;Metabolic dysfunction;Metabolism;Methods;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Mus;new technology;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;obesity development;Organ;Overnutrition;oxidation;Oxidative Stress;Pathogenicity;Pathway interactions;Patient Care;Patients;personalized care;Predisposition;preservation;Prevalence;Proximal Kidney Tubules;Publishing;Regulation;Research;Research Infrastructure;Role;stable isotope;Steatohepatitis;Stress;Techniques;Testing;Therapeutic Intervention;therapeutic target;Time;tissue injury;Tissues;Training;Transgenic Mice;Universities;western diet;Work

PROJECT_TITLE: In vivo hepato-renal metabolic flux dysregulation in obesity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Neurosciences;Nutrition;Obesity

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The majority of people in the US are overweight or obese and the lack of effective, long-term treatment options lends a particular urgency towards understanding the underlying physiologic mechanisms driving obesity. The purpose of these human and rodent studies are to investigate the impact of obesity and increased circulating fatty acid levels on the brain. The proposed studies in this R01 proposal will lay the foundation for future studies targeting brain glucose transport and metabolism alterations to treat and prevent the central nervous system complications of obesity.

PI_NAMEs: HWANG, JANICE JIN (contact)

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: Acute;Adult;Age;Alzheimer's Disease;Animal Model;Automobile Driving;Blood;Blood - brain barrier anatomy;Body mass index;Brain;Calories;Central Nervous System;Cerebrum;Clinical;Closure by clamp;cognitive function;combat;Control Groups;Coupled;Cues;Development;Eating;experimental study;Failure;Fat emulsion;fatty acid oxidation;Fatty Acids;Female;Food;Foundations;frontal lobe;Future;Glucose;glucose metabolism;glucose transport;Glucose Transporter;glucose uptake;Glycolysis;Glycosylated hemoglobin A;Goals;High Fat Diet;Hour;Human;Hyperglycemia;Individual;Infusion procedures;Insulin Resistance;Kinetics;Literature;Magnetic Resonance Spectroscopy;male;Maps;Measurement;Measures;Mediating;metabolic phenotype;Metabolism;Methodology;Modeling;Molecular;Muscle;Neurocognitive;Neurodegenerative Disorders;neuroimaging;Nonesterified Fatty Acids;obese person;Obesity;Overweight;oxidation;Palmitic Acids;Participant;Pathogenesis;Peripheral;Persons;Physiological;Plasma;Play;prevent;Process;Randomized;randomized, controlled study;Rattus;regional difference;Regulation;Research Design;response;Rodent;Rodent Model;Role;Saline;Satiation;Scanning;Signal Pathway;Signal Transduction;SLC2A1 gene;Sweden;Techniques;Technology;Thinness;Tissues;treatment strategy;Visual

PROJECT_TITLE: The impact of obesity on cerebral glucose transport and metabolism

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Latinos/as face Alzheimer’s disease and related dementias (ADRD) disparities and are projected to see the largest increase in United States dementia cases by 2060. To address this impending public health crisis, the proposed project will examine longitudinal changes in cognition based on cardiovascular disease risk, acculturation, small vessel disease, and ADRD biomarkers among diverse Latinos/as 50+ years old. Using a biopsychosocial approach, this project will provide nuanced characterization of risk factors for ADRD in this population which may lead to better informed clinical care, novel interventions, and may ultimately reduce ADRD disparities in this population.

PI_NAMEs: STICKEL, ARIANA  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Acculturation;Address;Adoption;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;Amyloid beta-Protein;Ancillary Study;Attenuated;Biological;Biological Markers;biopsychosocial;black men;black women;Brain;Brain Injuries;cardiovascular disorder risk;cardiovascular health;cerebrovascular pathology;Cerebrovascular system;Clinical;clinical care;Cognition;Cognitive;Cognitive aging;cognitive change;Communities;Data;Dementia;dementia risk;Development;Diabetes Mellitus;Disparity;Enrollment;epidemiologic data;Estrogens;ethnic difference;ethnic minority;Ethnic Origin;Face;Gender;Glial Fibrillary Acidic Protein;Goals;good diet;health disparity;Healthcare;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;human old age (65+);Impaired cognition;Incidence;Income;Individual;Intervention;Investigation;late life;Latina;Latina Population;Latino;Latino Population;Latinx;Life Expectancy;life span;Light;Link;Longitudinal Studies;Magnetic Resonance Imaging;male;Measures;Mediating;Memory;men;Mexican Americans;Microvascular Dysfunction;middle age;mild cognitive impairment;National Institute on Aging;Neurocognitive;neurofilament;novel;older adult;Outcome;Performance;Physical activity;Plasma;Population;Predisposition;Prevalence;programs;psychosocial;Public Health;racial population;Research;Resources;Risk;Risk Factors;Role;Sampling;Scientist;sex;social culture;stem;Study of Latinos;tau Proteins;Testing;tool;Training;United States;white matter;Woman

PROJECT_TITLE: Risk Factors for Alzheimer's Disease Among Latinos: Relationships Between Cardiovascular Disease Risk, Acculturation, Small Vessel Disease, and Alzheimer's Biomarkers

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE This project is aimed at examining the role of a specific structure, the mediodorsal thalamus, in cognitive control and flexibility. Our work will provide fundamental insights into thalamic circuits and how they may control cortical processing. Additionally, it will set the stage for future translational studies involving thalamic vulnerability in disease and the use of the thalamus as a target for intervention in a variety of cognitive disorders.

PI_NAMEs: HALASSA, MICHAEL M (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: anatomical tracing;Area;Attention;Award;Behavior;Behavioral;Brain;cell type;Cognition;Cognition Disorders;Cognitive;cognitive control;Communities;Cues;Data;density;Disease;Disinhibition;Dissection;Elements;Equilibrium;Esthesia;excitatory neuron;executive function;flexibility;Future;Genetic;Health;Human;Individual;insight;Intervention;Maps;Mediating;Mission;Modeling;Monitor;multi-electrode arrays;Mus;neural;Neurons;neurotransmission;optogenetics;Output;Pattern;Prefrontal Cortex;Process;programs;recruit;Research;response;Role;Schizophrenia;segregation;Sensory;Short-Term Memory;Signal Transduction;Structure;Testing;Thalamic Nuclei;Thalamic structure;Therapeutic;therapy development;tool;Transgenic Organisms;translational study;treatment strategy;United States National Institutes of Health;Work

PROJECT_TITLE: Behavioral and mechanistic dissection of a cognitive thalamo-cortical network

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: The proposed research is relevant to public health because this project will investigate the role of endoplasmic reticulum stress response in stroke. This is relevant to the NIH’s mission because the knowledge obtained from the proposed research will be the basis for potential new therapeutic strategies to improve neurologic function of stroke patients, which will advance the Nation’s capacity to protect and improve health.

PI_NAMEs: YANG, WEI  (contact)

PROJECT_TERMS: Acute;acute stroke;Affect;Aging;animal old age;Astrocytes;astrogliosis;ATF6 gene;biological adaptation to stress;Blood - brain barrier anatomy;Brain;brain cell;Cause of Death;Cell Survival;cell type;Cells;Cerebrovascular Circulation;Chronic;Cicatrix;clinically significant;Data;Development;Disease;druggable target;Elderly;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;Event;Functional disorder;gain of function;healing;Health;Homeostasis;Impairment;improved;Individual;Inositol;insight;Intervention;Ischemia;Ischemic Stroke;juvenile animal;Knock-in Mouse;Knowledge;Learning;Long term disability;long term recovery;loss of function;Maintenance;MAPK3 gene;Mission;mouse genetics;Mus;Names;Nerve Degeneration;Nervous System Physiology;neural circuit;Neurons;neuroprotection;neurotoxic;novel;novel therapeutic intervention;old mice;Organelles;Outcome;Pathologic;Pathway interactions;pharmacologic;Phase;Phenotype;Phosphotransferases;post stroke;preservation;Process;protein folding;Protein Kinase;Proteins;Proteome;proteostasis;Public Health;Quality of life;Recovery;Recovery of Function;Regulation;Reperfusion Therapy;Research;response;RNA;Role;sensor;sex;Shapes;Signal Transduction;Stroke;stroke model;stroke outcome;stroke patient;stroke recovery;stroke therapy;Synaptic plasticity;Therapeutic;therapeutic target;tool;translatome;United States National Institutes of Health;Work;XBP1 gene

PROJECT_TITLE: The Unfolded Protein Response in Ischemic Stroke

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative This project will analyze existing and publicly available data to identify genetic variants that either directly influence risk of orofacial clefts (OFCs) and subtypes or moderate the effects of maternal smoking, alcohol, and multivitamin/folate exposures during pregnancy. Results from this study will enhance our understanding of OFC biology by filling gaps in our knowledge of the genetic contributors and interacting maternal exposures influencing OFCs, and may ultimately be useful for risk and recurrence prediction and inform preventive or therapeutic interventions.

PI_NAMEs: SHAFFER, JOHN R (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Address;Affect;African;Alcohol consumption;Alcohols;Behavior Therapy;Biological;Biology;causal variant;Cleft Lip;Cleft lip with or without cleft palate;Cleft Palate;Clinical;cohort;Congenital Abnormality;craniofacial;Data;Data Set;Dental;Disease;Economics;Environmental Exposure;Etiology;Family member;Folic Acid;gene environment interaction;Genes;Genetic;genetic architecture;genetic association;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome wide association study;genome-wide;genome-wide analysis;genomic data;genomic locus;Genotype;Goals;Handedness;Heritability;Heterogeneity;Human;improved;Individual;Knowledge;Live Birth;Maps;maternal cigarette smoking;Maternal Exposure;maternal risk;Medical;Modeling;multi-ethnic;Multivitamin;novel;Nutritional;Operative Surgical Procedures;Oral;orofacial cleft;Participant;Pathway interactions;Phenotype;Play;Pregnancy;prenatal exposure;preventive intervention;Public Health;Publications;Recording of previous events;recruit;Recurrence;Research;Resources;response;Risk;risk prediction;risk variant;Role;Sample Size;Sampling;Services;Signal Transduction;Smoking;South Asian;Speech;Structure;Therapeutic Intervention;trait;Translating;Variant;whole genome;Work

PROJECT_TITLE: Investigating the role of genes, maternal exposures, and interactions on orofacial clefts

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Genetics;HIV/AIDS;Lung;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: MIAMI

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE: COPD is a multifactorial pathology and PLWH demonstrate and higher incidence of COPD even when adjusted for the smoking status. HIV tat and TGF-β signaling (upregulated by Tat, cigarette smoek and in COPD), dysregulate the airway microRNAome and this can have downstream effects on the transcriptome and signaling pathways leading to pathological hallmarks of COPD. Understanding the mechanism of miRNA dysregulation and its downstream effects can identify targets for intervention, and silencing HIV transcription by CRISPR based inactivation of cellular cofactor CyclinT1 only in HIV-infected cells can decrease the Tat burden in the airways and improve outcomes in HIV associated COPD.

PI_NAMEs: RAHMAN, IRFAN ;UNWALLA, HOSHANG JEHANGIR (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Abbreviations;Affect;Aging;Air;airway epithelium;Animal Model;Binding;bronchial epithelium;Cells;cellular targeting;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease;Cigarette;cigarette smoke;Circadian Dysregulation;circadian regulation;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;comorbidity;Compensation;Complement;Continuity of Patient Care;CRISPR/Cas technology;cyclin T1;Cyclins;Data;Development;Disease;DNA;DNA Polymerase II;Drosophila genus;efficacy evaluation;Epithelial Cells;Etiology;Event;Excision;Exposure to;functional decline;Functional disorder;gene function;Genes;Genetic Transcription;Genome;Goals;Guide RNA;Health;HIV;HIV Receptors;Homeostasis;Human;improved;improved outcome;Incidence;Inflammation;Intervention;Legal patent;Liquid substance;Lung;Mediating;Mediator;Messenger RNA;MicroRNAs;Mitochondria;mitochondrial dysfunction;Morbidity - disease rate;mortality;mouse model;Mucociliary Clearance;Mutation;Nicotine;non-smoker;Outcome;Pathologic;Pathology;Pathway interactions;Peptide Signal Sequences;Persons;Play;Polyadenylation;Positive Transcriptional Elongation Factor B;prevent;promoter;Proteins;Pulmonary Emphysema;pulmonary function;pulmonary function decline;Regulation;Reporting;response;Risk;Risk Factors;RNA Recognition Motif;Role;senescence;Signal Pathway;Signal Transduction;Site;Smoker;Smoking Status;System;Tobacco smoke;Toxic effect;transcriptome;transcriptomics;Transforming Growth Factor beta;Translating;United States;Viral;Viral Genome

PROJECT_TITLE: Aberrant Micro-managing of the Airway Epithelial Transcriptome in HIV-associated COPD

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Disorders such as Post-Traumatic Stress Disorder (PTSD) and schizophrenia are caused or worsened by stress exposure, and have devastating effects on patients and their families. Current, nonselective treatments such as prazosin and propranolol are often inadequate. The proposed research will examine the receptor subtypes through which stress impairs higher brain functioning in order to design more effective therapies.

PI_NAMEs: ARNSTEN, AMY F.T. (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Acute;acute stress;ADRB1 gene;Affinity;Amygdaloid structure;Animals;antagonist;Astrocytes;Automobile Driving;biological adaptation to stress;Brain;Cardiac;Catecholamines;cell type;Cells;Chronic stress;Cognition;Cognitive;Cognitive deficits;Confocal Microscopy;Coupled;Cyclic AMP;Data;Dendritic Spines;design;Disease;Dissection;Dose;effective therapy;Emotional;Exposure to;Family;fighting;gain of function mutation;Goals;Heart;Human;Hypotensives;Immunoelectron Microscopy;Immunofluorescence Immunologic;Impairment;Interneurons;Iontophoresis;Label;Length;Location;Macaca mulatta;Mediating;Memory impairment;Mental disorders;mental representation;Microglia;Molecular;Monkeys;Myocardium;Neurons;Nightmare;Norepinephrine;Norepinephrine Receptors;Patients;Performance;Physiological;Post-Traumatic Stress Disorders;Potassium Channel;Prazosin;Prefrontal Cortex;presynaptic;Primates;Propranolol;Pyramidal Cells;receptor;Research;response;Risk;Risk Factors;Role;Schizophrenia;Second Messenger Systems;sedative;Sensory;Short-Term Memory;side effect;Site;Stress;stress reduction;stressor;Techniques;Testing;Therapeutic;treatment strategy;voltage;Work

PROJECT_TITLE: Prefrontal impairment with stress- NE receptor subtype mechanisms.

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: OVERALL: PROJECT NARRATIVE The Wake Forest Baptist Comprehensive Cancer Center (WFBCCC) in Winston-Salem, North Carolina serves the people of the Appalachian region (North Carolina, Virginia, and West Virginia) and is a nationally recognized hub for clinical, basic, and population scientists focused on the prevention and early detection of cancer, developing novel cancer therapies, and improving the health of cancer survivors. Through the support of the P30 Cancer Center Support Grant, WFBCCC provides research resources in support of its scientists, with the goal of reducing the cancer burden regionally and nationally through cutting-edge research, professional education, and community outreach and engagement.

PI_NAMEs: MESA, RUBEN A. (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Appalachian Region;authority;Automobile Driving;Baptist Church;base;Basic Science;behavioral health;biobehavior;biomedical scientist;Biotechnology;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer genetics;Cancer health equity;cancer prevention;cancer research center director;Cancer Survivor;cancer therapy;care providers;Catchment Area;Cells;Cigarette;Clinical;Clinical Oncology;Clinical Sciences;clinical trial participant;Clinical Trials;Collaborations;Communities;community engagement;Community Health Education;Community Outreach;Comprehensive Cancer Center;County;Development;Disparity;Doctor of Philosophy;Education;Education and Outreach;Ensure;Environment;ethnic minority;Ethnic Origin;Evaluation;Excess Mortality;Exclusion;Faculty;Funding;Goals;Growth;Health;health disparity;Health Personnel;Home;improved;Incidence;Individual;Industry;Infrastructure;innovation;Institution;interdisciplinary collaboration;International;Intervention;intervention delivery;Intervention Studies;Intervention Trial;Investments;K-Series Research Career Programs;Leadership;Malignant Neoplasms;medical schools;medically underserved;Mentors;Mission;Morbidity - disease rate;mortality;Movement;Names;National Cancer Institute;neuro-oncology;next generation;North Carolina;novel;outreach;Patient Care;patient navigation;Persons;Physicians;Population;population based;Population Heterogeneity;Population Sciences;Positioning Attribute;Poverty;precision medicine;Prevention;Prevention strategy;Primary Care;Productivity;Professional Education;programs;Race;racial minority;Recording of previous events;recruit;Recurrence;Research;Research Infrastructure;Research Peer Review;Research Personnel;Resource Sharing;Resources;Rural;Rural Appalachia;Rural Community;Rural Population;Science;Scientific Advances and Accomplishments;Scientist;Screening for cancer;Services;Signal Transduction;smoking-related cancer;social health determinants;Societies;Southeastern United States;Specialist;Speed;Strategic Planning;success;survivorship;Technology;therapy resistant;Tobacco;Training;Training and Education;Translating;Translational Research;Translations;tumor metabolism;underserved area;Uninsured;United States;Universities;Virginia;West Virginia

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: PASCHE, BORIS  (contact)

PROJECT_TERMS: Achievement;Address;Administrator;Advisory Committees;anti-cancer research;Baptist Church;Budgets;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer education;Cancer health equity;cancer research center director;Catchment Area;Charge;Clinical;Clinical Data;Clinical Protocols;Collaborations;Collection;Communication;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;cost;cost effective;Data;data management;Database Management Systems;design;Development;Doctor of Philosophy;Documentation;Education;Ensure;Environment;Evaluation;experience;Faculty;Faculty Recruitment;Fees;Fostering;Foundations;Funding;Goals;Grant;Health;Heart Atrium;Human Resources;Individual;Informatics;Information Systems;Institution;Intramural Research;Leadership;Link;Maintenance;Malignant Neoplasms;meetings;member;Mission;NCI Center for Cancer Research;Occupational activity of managing finances;Outcome;Patient Outcomes Assessments;Persons;Policies;Population Research;Positioning Attribute;Process;Productivity;programs;Progress Reports;Publications;Qualifying;recovery services;recruit;Reporting;Research;Research Activity;Research Project Grants;Resource Sharing;Resources;Source;Strategic Planning;success;Surveys;symposium;Training;Training and Education;Universities;Vision

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Sleep Research

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

ORG_STATE: MO

PHR: Project Narrative Sleep and feeding are two essential and mutually exclusive behaviors that are homeostatically regulated, and deviations from the relative stability that is maintained by both feeding and sleep homeostasis can have negative consequences for an individual health. In this proposal, we will uncover the logic by which individual sleep-promoting neurons can integrate sensory stimuli and internal state variables to modulate behavioral flexibility between sleep and feeding.

PI_NAMEs: DISSEL, STEPHANE  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Acetylcholine;Animals;Behavior;Behavioral;Cells;Central Nervous System;circadian pacemaker;connectome;Data;Decision Making;Diet;Drosophila genus;Ensure;Environment;feeding;Feeding behaviors;flexibility;fly;gamma-Aminobutyric Acid;Genes;Genetic;Health;Homeostasis;Homologous Gene;Human;Hunger;Individual;interest;Investigation;Jellyfish;Logic;Mammals;Methods;Modeling;Modernization;Molecular;motivated behavior;Motivation;Nature;Nerve;Nervous System;neural circuit;Neurobiology;neurochemistry;Neuromodulator;neuronal circuitry;Neurons;Neurotransmitters;novel;Nutrient;offspring;Organism;Performance;Personal Satisfaction;Physiological;Physiology;Positioning Attribute;postsynaptic;Process;reconstruction;Research;Role;Satiation;sensory input;sensory integration;sensory stimulus;Serine Protease;Signal Transduction;Sleep;sleep behavior;sleep regulation;Spinal Cord;success;transmission process

PROJECT_TITLE: Investigation of a newly identified group of neurons regulating sleep and feeding behaviors.


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Narrative How disseminated tumor cells (DTCs) initiate the metastatic colonization process in the bone remains poorly understood. We discovered that DTCs may establish direct cell-cell contact with mesenchymal stem cells (MSCs) in the perivascular niche, and co-migrate toward the site of osteogenesis upon activation of bone turnover. We propose to investigate the molecular mechanisms underlying DTC-MSC interaction and assess the impact of bone turnover on early-stage bone colonization of breast cancer cells.

PI_NAMEs: ZHANG, XIANG  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Accounting;Actins;Adherens Junction;Adjuvant;Adjuvant Therapy;Affect;Aging;Biology;bisphosphonate;Blood Vessels;bone;Bone Injury;Bone Marrow;Bone Regeneration;bone repair;Bone Tissue;bone turnover;Breast Cancer Cell;cancer cell;Cell Communication;Cell Count;cell motility;cell type;Cells;Cessation of life;Clinical;cofilin;Communication;Cytoskeletal Modeling;Data;Dendritic Spines;Dependence;design;Development;Diagnosis;Elasticity;Epidemiologic Factors;Equilibrium;Etiology;Excision;Exhibits;Fostering;Fracture;Freezing;Frequencies;Gap Junctions;Goals;Homeostasis;Injury;insight;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Mesenchymal Cell Neoplasm;Mesenchymal Differentiation;Mesenchymal Stem Cells;Metastatic breast cancer;Metastatic Neoplasm to the Bone;Metastatic/Recurrent;Micrometastasis;Microscopic;migration;Molecular;mouse model;Neoplasm Metastasis;neoplastic cell;Organ;Osteoblasts;Osteoclasts;Osteogenesis;osteogenic;Pathologic;Patients;Physiological;Pliability;Process;Publishing;recruit;Recurrence;Research;Rest;risk prediction;Role;Signal Transduction;Site;stem cell migration;Stretching;Structure;Testing;Therapeutic;Tissues;trait

PROJECT_TITLE: Osteoclast-Independent Mechanisms of Early-Stage Bone Colonization of Breast Cancer

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


PROJECT_TERMS: Advocate;anti-cancer research;Award;Baptist Church;Cancer Center;Cancer Center Support Grant;cancer education;Cancer Research Project;career;career development;Catchment Area;Clinical;Clinical Protocols;Clinical Sciences;Clinical Trials;community engagement;Community Networks;Community Outreach;Comprehensive Cancer Center;data management;design;Development;Disease;Doctor of Philosophy;Education;Education Projects;Educational workshop;Ensure;experience;Faculty;Foundations;Funding;Goals;Grant;high school;High School Student;Historically Black Colleges and Universities;Individual;Infrastructure;innovation;Institution;Investments;K-Series Research Career Programs;Malignant Neoplasms;Medical;member;Mentors;Monitor;NCI Center for Cancer Research;next generation;Outcome;Population Scientist Supplement (R25);Postdoctoral Fellow;pre-doctoral;Process;programs;recruit;Research;Research Personnel;Resource Sharing;Series;Services;Strategic Planning;Students;summer internship;Systems Integration;tool;Training;Training and Education;Training and Infrastructure;training data;training opportunity;Training Programs;Training Support;translational pipeline;Translational Research;Travel;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Wages;Woman;Writing

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE GABA is an important metabolite regulating neuron function as well as cell growth, differentiation and migration. We have discovered a transporter protein, SLC45A4, which controls the GABA levels in cancer cells. Our goal is to figure out how SLC45A4 works in the context of GABA production and how to regulate GABA level through SLC45A4.

PI_NAMEs: SU, XIAOYANG  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Affect;Amino Acids;Antibodies;Arginine;Biochemical;Biochemistry;cancer cell;Carrier Proteins;Cations;cell growth;Cell Line;Cell membrane;Cell Physiology;Cell Proliferation;Cells;Central Nervous System;Chemicals;Coupled;Cultured Cells;Cytosol;cytotoxicity;Data;Data Set;Disease;drug development;Drug Targeting;Environment;extracellular;Family;Family member;gamma-Aminobutyric Acid;Genes;Glucose;Glucose Transporter;Goals;Human;Immunofluorescence Immunologic;Investigation;Ions;Knock-out;Knowledge;Label;Mass Spectrum Analysis;Measures;Mediating;member;Membrane;Membrane Transport Proteins;Mendelian disorder;Metabolic;Metabolism;metabolomics;migration;Mitochondria;mitochondrial membrane;multiple omics;Neuroglia;Neurons;Neurotransmitters;new therapeutic target;Normal Cell;novel;novel therapeutics;Organelles;Ornithine;ornithine transporter;Orphan;overexpression;Paraquat;Peripheral;Plants;preference;Production;programs;Property;Proteins;Protons;Putrescine;Regulation;Resolution;Role;Sequence Homology;small molecule;solute;Spermidine;Spermine;stable cell line;stable isotope;Sucrose;Techniques;Testing;Tissues;transcriptomics;uptake;Work

PROJECT_TITLE: Investigating the Role of SLC45A4 in GABA Metabolism

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_DEPT: FAMILY MEDICINE

PHR: PROJECT NARRATIVE Established smoking cessation medications effectively treat withdrawal symptoms but do little to address the powerful influence that cues and contexts have on smoking behavior. Across both basic and clinical research, β-adrenergic medications have demonstrated potential to reduce these influences by disrupting the key cognitive processes that unfold when smoking cues and contexts are encountered. This project will use neuroimaging to determine the effects of these medications on brain responses to smoking cues and contexts in human cigarette smokers, providing vital information on the mechanisms responsible for their effect and informing further treatment development efforts.

PI_NAMEs: OLIVER, JASON ANTHONY (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Acute;addiction;Address;Adjuvant Analgesic;Adjuvant Therapy;Adrenergic Agents;Adrenergic Antagonists;Adrenergic beta-Antagonists;Adult;Amygdaloid structure;Attention;Attenuated;Automobile Driving;Award;Basic Science;Behavior;Behavioral;Behavioral Mechanisms;behavioral response;beta-adrenergic receptor;Brain;Brain region;cerebrovascular;Cerebrovascular Circulation;Cessation of life;Cigarette;Cigarette Smoker;cigarette smoking;Clinical;Clinical Research;cognitive control;cognitive process;craving;Crossover Design;cue reactivity;Cues;design;Development;drug development;Drug Modulation;Drug Targeting;Drug usage;Emotional;Exposure to;Follow-Up Studies;functional MRI scan;Future;Goals;Health Personnel;Hippocampus;Hour;Human;Image;imaging science;Impairment;improved;Intervention;Laboratories;Medial;Mediating;Mediation;Memory;Methods;Modeling;Motivation;National Institute of Drug Abuse;neural;neurobiological mechanism;neuroimaging;neuromechanism;nicotine patch;Nicotine Withdrawal;Participant;Pathway interactions;Pattern;Perfusion;Pharmaceutical Preparations;pharmacologic;pill;Placebos;Play;Policy Maker;pre-clinical;Pre-Clinical Model;preclinical study;preference;Prefrontal Cortex;Procedures;programs;Propranolol;Protocols documentation;Psychological reinforcement;Public Health;Relapse;Research;Research Personnel;response;Rest;Retrieval;Rodent Model;Role;Sampling;Scanning;Scientist;Series;Shapes;Smoker;Smoking;smoking abstinence;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;smoking cue;Stimulus;System;Testing;therapy development;Translational Research;United States;Withdrawal Symptom;Work

PROJECT_TITLE: Beta-Adrenergic Modulation of Drug Cue Reactivity: Neural and Behavioral Mechanisms

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Obesity;Prevention;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PROJECT_TERMS: Address;Adolescent and Young Adult;Advanced Malignant Neoplasm;Alcohol consumption;Alcohols;American College of Radiology Imaging Network;Area;Award;Baptist Church;base;Basic Science;Biological Markers;Calendar;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research;Cancer Control Research Program;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;care delivery;care providers;Caregivers;Caring;Catchment Area;Clinical;Clinical Sciences;Collaborations;Colon;Communities;community based research;Community Clinical Oncology Program;community engagement;Community Outreach;community partners;Comprehensive Cancer Center;computed tomography screening;Continuity of Patient Care;COVID-19 pandemic;Development;digital health;Direct Costs;Disparity;Doctor of Philosophy;Eastern Cooperative Oncology Group;Effectiveness;Electronic Health Record;epidemiology study;Etiology;Fostering;Funding;Genetic Research;Goals;Health behavior;health disparity;health related quality of life;Health Services Accessibility;Healthcare Systems;healthy lifestyle;Home;implementation science;improved;Incidence;Informatics;innovation;Institution;interdisciplinary collaboration;Intervention;Intervention Studies;Journals;life span;low dose computed tomography;Lung;Malignant Neoplasms;meetings;member;Morbidity - disease rate;mortality;Names;National Cancer Institute;National Institute of Drug Abuse;North Carolina;Obesity;Outcome;Participant;Patient Outcomes Assessments;Peer Review;Periodicals;Physical activity;Policies;pragmatic study;Process;programs;psychosocial;public policy on tobacco;Publications;Quality of life;Randomized;recruit;reduce symptoms;Research;Research Design;Research Personnel;Research Priority;research study;Resource Sharing;Resources;Risk Factors;Risk Reduction Behavior;Rural;Rural Community;Science;Screening for cancer;Series;Smoking;smoking cessation;Smoking Cessation Intervention;social determinants;Source;Supportive care;Survivors;survivorship;symposium;Symptom Burden;Technology;Tobacco;tobacco control;tobacco prevention;tobacco regulatory science;Tobacco use;Training Programs;Translating;translational impact;Translational Research;United States National Institutes of Health;Vision;Vulnerable Populations;Work

PROJECT_TITLE: Cancer Prevention and Control Research Program


NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Neurosciences;Rehabilitation

ORG_CITY: COLLEGE PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: The proposed research is relevant to public health because hearing loss in the U.S. affects two- thirds of adults age 70 and older, many of whom would have an improved quality of life given the partial restoration of hearing from a technological intervention called a bionic cochlear implant. This research aims to understand and improve speech understanding for older (>65 yrs) cochlear- implant users. Thus, the proposed research is relevant to NIH’s mission to develop new knowledge and improve technologies to help treat disability, NIA’s mission to understand the biological effects of aging, and NIDCD’s mission to provide technological interventions for hearing loss.

PI_NAMEs: GOUPELL, MATTHEW J. (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Accounting;Acoustic Nerve;Acoustics;Action Potentials;Adult;Affect;Age;age effect;age related;age related decline;Aging;aging auditory system;Auditory;Auditory area;auditory processing;baby boomer;Biological;Bionics;Brain Stem;Bypass;Cochlea;Cochlear Implants;Cognitive;Communication;Compensation;Complex;Cueing for speech;design;disability;Effectiveness;effectiveness evaluation;electric impedance;Electric Stimulation;Electrodes;Electrophysiology (science);experimental study;Generations;Goals;Grant;Hearing;hearing impairment;hearing restoration;improved;innovation;Knowledge;Language;Link;Location;Measurement;Measures;Mission;National Institute on Deafness and Other Communication Disorders;neural;older adult;Older Population;Outcome;Perception;Performance;Peripheral;Play;Presbycusis;Public Health;Quality of life;Rehabilitation therapy;remediation;Research;Role;Scanning;Signal Transduction;simulation;Speech;speech accuracy;Speech Perception;Stimulus;Technology;technology intervention;Testing;United States National Institutes of Health;X-Ray Computed Tomography;young adult

PROJECT_TITLE: Peripheral and central contributions to auditory temporal processing deficits and speech understanding in older cochlear implantees

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Rare Diseases;Rural Health;Tobacco;Tobacco Smoke and Health

PROJECT_TERMS: actionable mutation;Acute Myelocytic Leukemia;Address;Adult;African American population;Algorithms;American Association of Cancer Research;anti-cancer research;Area;Articulation;Baptist Church;base;Basic Science;Biology;biomarker identification;cancer cell;Cancer Center Support Grant;cancer genetics;cancer genome;cancer genomics;cancer heterogeneity;cancer type;Catchment Area;Cells;Cellular Metabolic Process;Citric Acid Cycle;Classification;Clinical;Clinical Cancer Center;clinical investigation;Clinical Investigator;Clinical Oncology;Clinical Research;Clinical Trials;Collaborations;Colorectal Cancer;Communication;companion diagnostics;Comprehensive Cancer Center;County;Coupled;COVID-19 pandemic;Data;data mining;data sharing;Death Rate;design;Diagnostic Neoplasm Staging;Disease;Disparity;Doctor of Philosophy;Drug resistance;Epigenetic Process;epigenome;Ethnic Origin;Event;Exhibits;Foundations;Funding;Genetic;genetic information;Genomics;Genomics Shared Resource;Geography;Grant;health disparity;Healthcare;Hematologic Neoplasms;imaging agent;improved;Incidence;individualized medicine;inhibitor;insight;Institution;inter-institutional;Intervention;Isocitrate Dehydrogenase;Journals;ketoglutarate dehydrogenase;leukemia;liquid biopsy;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Medicine;Melanoma;member;Metabolic;Metabolism;Mission;Mitochondria;mitochondrial metabolism;Molecular Probes;Monitor;Morbidity - disease rate;mortality;Multiple Myeloma;Mutation;Nature;NCI Center for Cancer Research;Neoplasms;next generation sequencing;novel;Nucleic Acids;Oncology;Oxidation-Reduction;patient oriented;Patients;Peer Review;personalized medicine;Persons;Phase;phase 3 study;phase change;Physicians;precision medicine;precision oncology;Precision therapeutics;programs;Protocols documentation;Publications;Publishing;Pyruvate Dehydrogenase Complex;Race;Recommendation;Recurrence;Research;Research Personnel;research study;Resistance;response;Role;rural African American;Rural Population;Sampling;Science;Scientist;Seminal;single cell sequencing;Smoker;Solid Neoplasm;Staging System;System;targeted treatment;Technology;Testing;Therapeutic Agents;therapy resistant;Tissues;TNM;Tobacco;Tobacco smoking behavior;Tobacco-Related Carcinoma;Translating;translational impact;Translational Research;translational scientist;treatment response;tumor initiation;tumor metabolism;tumor microenvironment;tumor progression;United States Food and Drug Administration

PROJECT_TITLE: Cancer Genetics and Metabolism Research Program


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Heart attack (myocardial infarction) is a major killer in western society, so there is a drastic need for therapies to avoid myocardial injury. The heart is a very metabolically demanding organ, but there are still large gaps in our knowledge of cardiac metabolism. We have identified several key metabolic events that take place during and after heart attack, and this project will investigate how manipulating these events can impact the outcome of heart attack. Specifically, under conditions of chronic hyperglycemia such as seen in diabetes, there is an elevation of the metabolite methylglyoxal (MGO), and this is generally thought to be detrimental to the heart. However, we have identified novel mechanisms in which acute MGO may elicit beneficial signaling effects to protect against heart attack.

PI_NAMEs: BROOKES, PAUL S (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Ablation;Acids;Acute;Acute myocardial infarction;Address;Adult;Alkynes;alpha ketoglutarate;Angioplasty;ATP Synthesis Pathway;Biological Process;Cardiac Myocytes;Cardiac Surgery procedures;cardioprotection;Cardiotonic Agents;Cell Membrane Permeability;Chemistry;Chronic;Complex;Diabetes Mellitus;diabetic;Dioxygenases;Electron Transport;Electron Transport Complex III;Engineering;Enzymes;Event;FDA approved;Feedback;Fluorescence;Funding;Generations;gluconolactone oxidase;Glucose;Glycolysis;Glyoxal;Heart;Heart Injuries;heart metabolism;High Fat Diet;Hyperglycemia;In Situ;in vivo;inhibitor;innovation;insight;Insulin;Intervention;Ischemia;ischemic injury;Ischemic Preconditioning;Knowledge;Mediating;Metabolic;Metabolic acidosis;Metabolism;metabolomics;Mitochondria;mitochondrial permeability transition pore;Modeling;Mus;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Necrosis;novel;Organ;Outcome;overexpression;oxidation;Paper;Pathologic;Pathology;Patients;Perfusion;Pharmaceutical Chemistry;Pharmaceutical Preparations;Potassium;programs;Proteins;Proteomics;Publishing;Pyruvaldehyde;Reactive Oxygen Species;Recombinants;Regulation;Reperfusion Injury;Reperfusion Therapy;Research;Role;Schedule;sexual dimorphism;Signal Transduction;small molecule inhibitor;small molecule therapeutics;Societies;Stress;Succinates;Supplementation;System;Testing;Therapeutic;thrombolysis;Tissues;type I diabetic;Work

PROJECT_TITLE: Acid, Succinate and Glyoxal Metabolism in Ischemia

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy

PROJECT_TERMS: 3-Dimensional;Ablation;Acoustics;Adaptive Immune System;Antibodies;Area;Articulation;Autophagocytosis;Baptist Church;base;Basic Science;Biocompatible Materials;Biomedical Engineering;Biotechnology;Blood;Cancer Biology;Cancer Burden;cancer cell;Cancer Center Support Grant;cancer diagnosis;cancer drug resistance;cancer initiation;cancer recurrence;cancer therapy;Cancer Vaccines;career development;Catchment Area;Cells;Cellular biology;Clinical Research;Clinical Trials;Collaborations;Communication;Comprehensive Cancer Center;Computer Models;computerized tools;COVID-19 pandemic;deep learning algorithm;design;Development;Devices;Diagnosis;Diagnostic;DNA Damage;Doctor of Philosophy;Drug resistance;Electromagnetic Fields;Electroporation;Engineering;Ensure;Epigenetic Process;FRAP1 gene;Funding;Generations;Goals;Grant;health disparity;high throughput screening;Image;image guided;Imaging Device;Immunology;Immunosuppression;Immunotherapeutic agent;improved;In Vitro;in vivo;Innate Immune System;innovation;innovative technologies;inter-institutional;interdisciplinary collaboration;Interferons;invention;Journals;knowledge integration;Label;Lead;Leadership;Link;Malignant Neoplasms;medical schools;member;Methods;Microfluidics;Modeling;Molecular;Monitor;Multi-Drug Resistance;nanoparticle;Nature;NCI Center for Cancer Research;Neoplasm Circulating Cells;Neoplasm Metastasis;New Agents;novel;Oncogenic;Oncology;Organoids;Pathway interactions;patient response;Patients;Peer Review;PIK3CG gene;Pre-Clinical Model;Primary carcinoma of the liver cells;Process;programs;Publications;Publishing;PUVA Photochemotherapy;radio frequency;Recurrence;Regulation;Reporting;Research;Research Personnel;research study;Schools;Science;Scientist;Screening for cancer;Seminal;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;simulation;small molecule inhibitor;Strategic Planning;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Therapeutic;therapy resistant;Tissues;Tobacco use;translational impact;Translational Research;Treatment outcome;tumor;Tumor Escape;Tumor Immunity;tumor initiation;tumor progression;Universities;uptake;Viral Cancer;Virginia;Virus Diseases

PROJECT_TITLE: Signaling and Biotechnology Research Program


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Mental Health;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Accumulating evidence indicates that astrocytes, classically considered to serve passive support roles, play important functions in learning, memory, and information processing by actively modulating neuronal activity and synaptic function. The present proposal aims to define the functional role of astrocytes in amygdala-related behavioral tasks using in vivo and in ex vivo preparations. Defining the impact of astrocyte-neuron signaling on amygdala function may reveal novel mechanisms involved in brain disorders, such as Posttraumatic Stress Disorder (PTSD) and excessive anxiety.

PI_NAMEs: ARAQUE, ALFONSO  (contact);KOFUJI, PAULO

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Address;Amygdaloid structure;Animal Behavior;Anxiety;Anxiety Disorders;Association Learning;Astrocytes;Behavior;Behavioral;Brain;Brain Diseases;Calcium;calcium indicator;cell type;cellular targeting;CNR1 gene;Communication;conditioned fear;Coupled;Cues;designer receptors exclusively activated by designer drugs;Disease;Electrophysiology (science);Emotional;endocannabinoid signaling;Endocannabinoids;excessive anxiety;Extinction;Fiber;Fright;gain of function;Genetic;Goals;Image;Impairment;in vivo;information processing;insight;Investigation;Knowledge;Learning;Light;loss of function;Measurement;Measures;Medial;melanopsin;memory process;Methods;Monitor;mouse model;Mus;Nervous System Disorder;neurochemistry;Neurons;neurotransmission;Neurotransmitters;novel;Optics;optogenetics;Output;Pathway interactions;Pattern;pharmacologic;Phase;Photometry;Physiological;Play;post-traumatic stress;Post-Traumatic Stress Disorders;Preparation;Property;receptor;receptor expression;Research;response;Role;selective expression;Signal Transduction;Slice;Specificity;Synapses;synaptic function;synaptic inhibition;Synaptic Transmission;Syndrome;targeted treatment;Testing;Transgenic Mice;Work

PROJECT_TITLE: Astrocyte activity in amygdala-related fear conditioned behaviors

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Breast Cancer;Cancer;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Women's Health Research

PROJECT_TERMS: Address;Adult;Affect;aging population;Antibodies;Area;Award;Baptist Church;base;Biological;Biological Response Modifier Therapy;Biophysics;Brain;Brain Neoplasms;brain tumor imaging;cancer cell;Cancer Center Support Grant;Canis familiaris;Catchment Area;cell type;Cells;chemotherapy;Clinical;Clinical Research;Clinical Trials;Cognitive Therapy;Collaborations;Communication;Community Clinical Oncology Program;Comprehensive Cancer Center;COVID-19 pandemic;Cytotoxin;Death Rate;Department of Defense;design;Development;Devices;Disease;Disease Progression;Doctor of Philosophy;drug candidate;Drug Delivery Systems;Electromagnetic Fields;Electroporation;Evaluation;Faculty;Frequencies;Funding;Glioblastoma;Glioma;human disease;human model;Immune;Impaired cognition;improved;innovation;inter-institutional;International;Intervention;Intervention Trial;investigator-initiated trial;Journals;Knowledge;Lead;Malignant Breast Neoplasm;Malignant Glioma;Malignant neoplasm of lung;Malignant Neoplasms;Medical Device;Medicine;member;Metastatic breast cancer;Metastatic malignant neoplasm to brain;Mission;Molecular;Molecular Target;molecular targeted therapies;Morbidity - disease rate;nano;National Cancer Institute;Nature;Neoplasm Metastasis;neoplastic cell;neuro-oncology;Neurosciences;neurotoxic;New England;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenic;Oncology;Oncolytic viruses;Participant;Pathway interactions;Patients;Peer Review;Peptides;Peripheral Nervous System Diseases;Personal Satisfaction;Phase;Physicians;Play;precision medicine;preservation;Prevention;Primary Brain Neoplasms;programs;Publications;Publishing;Quality of life;Radiation therapy;radio frequency;Recommendation;Recording of previous events;recruit;Recurrence;Reporting;Research;Research Personnel;research study;response;Role;Rural;Science;Scientist;Secure;Seminal;Signal Transduction;stem;stem-like cell;Supportive care;survivorship;Symptoms;Techniques;Therapeutic;therapy resistant;Toxic effect;Training;Translating;translational impact;translational scientist;treatment effect;tumor;tumor initiation;tumor microenvironment;tumor progression;Viral

PROJECT_TITLE: Neuro-Oncology Research Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Advocacy;Advocate;Affect;African American;African American population;American Indians;analytical tool;Appalachian Region;Awareness;Baptist Church;biomedical scientist;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;care systems;Caring;Catchment Area;Clinical;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community advisory board;community collaboration;community engaged intervention;community engaged research;community engagement;Community Outreach;Comprehensive Cancer Center;County;Data Collection;design;Development;Diet Habits;Discrimination;Disparity;Doctor of Philosophy;Education;Education and Outreach;Educational Activities;Effectiveness;Ensure;Environmental Exposure;ethnic minority;Ethnic Origin;evidence base;Evidence based practice;Future;Geography;Goals;Health;health care availability;health determinants;health disparity;Health Personnel;Health Promotion;Health Services Accessibility;Healthcare;Heart Atrium;Hispanic;Hispanic Populations;Individual;Infrastructure;Intervention;Intervention Studies;Knowledge;low health literacy;Malignant Neoplasms;medical specialties;Medicine;Minority Participation;Mission;Monitor;Morbidity - disease rate;mortality;NCI Center for Cancer Research;next generation;North Carolina;Obesity;operation;Patient Care;patient navigation;Patient Participation;Patients;Policies;Population;population health;Poverty;Prevention approach;programs;Race;racial minority;Research;Research Activity;Resources;Risk Factors;Rural;rural area;rural dwellers;Rural Population;Screening for cancer;social health determinants;Special Population;Tobacco use;Tobacco Use Cessation;Training;Training Activity;Underserved Population;Virginia;Voice;West Virginia

PROJECT_TITLE: Community Outreach and Engagement