NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Project Narrative  Mitochondrial iron uptake and consequent stimulation of reactive oxygen species formation contributes to hepatotoxicity. The proposed study will elucidate the molecular pathways of mitochondrial iron uptake and  exchange, specifically the role of mitoferrin and its possible interaction with the mitochondrial calcium uniporter complex. These studies will fill an important gap in our understanding of iron-dependent hepatotoxicity, and the knowledge gained should lead to new therapies for hepatic diseases associated with iron overload.

PI_NAMEs: LEMASTERS, JOHN J (contact);NIEMINEN, ANNA-LIISA

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acetaminophen;acetaminophen-induced liver injury;Address;Affect;Affinity;Area;Binding;Binding Sites;Bioenergetics;Biological Assay;Biology;calcium uniporter;Cations;Cell membrane;Cell Membrane Permeability;Cells;Citrates;clinically relevant;cofactor;Complex;Confocal Microscopy;Core Protein;Data;Divalent Cations;DNA Damage;Endosomes;experimental study;Ferritin;Generations;Genetic Models;Heme;hepatocellular injury;Hepatocyte;Hepatotoxicity;Homeostasis;Hydroxyl Radical;Image;In Vitro;in vivo;Inner Limiting Membrane;Inner mitochondrial membrane;innovation;insight;Intervention;Iron;iron metabolism;Iron Overload;Kinetics;Knock-out;Knowledge;Liver diseases;Lysosomes;Measurement;Mediating;Membrane;Membrane Potentials;Membrane Proteins;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Proteins;Modeling;Molecular;Mutation;new therapeutic target;novel;novel therapeutics;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Permeability;Physiological;Play;Predisposition;prevent;Process;Protein Isoforms;Proteins;Reaction;Reactive Oxygen Species;Role;SLC11A2 gene;Sulfur;superresolution microscopy;Time;tool;Toxic effect;Transition Elements;uptake

PROJECT_TITLE: Mechanisms of Mitochondrial Iron Uptake: New Therapeutic Targets in Hepatotoxicity

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Hematology;Liver Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: Newark

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Relevance The overarching goal of this proposal is to improve our understanding of how tissue injury occurs in patients with disorders termed ‘porphyrias’ that encompass eight genetic and several acquired diseases caused by abnormal accumulation of natural pigment byproducts. Another important aspect of our proposal is to identify novel potential therapies, and drugs that should be avoided by individuals with porphyria because they may worsen their disease.

PI_NAMEs: OMARY, BISHR  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Abbreviations;Acute;Acute Intermittent Porphyria;Alcohol consumption;Aminolevulinic Acid;Animal Model;Biochemical;bone;Bone Marrow Transplantation;Brain;carboxylate;Cell Culture Techniques;cell injury;constitutive androstane receptor;Data;Deferoxamine;Detection;dimer;Disease;Disease Progression;Dissociation;drug candidate;Drug Metabolic Detoxication;Drug Modelings;Drug Screening;Drug usage;end stage liver disease;Enzymes;Erythropoietic Porphyria;Erythropoietic Protoporphyria;Esterification;Event;Excretory function;Experimental Models;ferrochelatase;Genetic;Genetic Diseases;Glycine;Goals;Heme;Hepatitis C;high throughput screening;improved;In Vitro;in vivo Model;Individual;Infection;Investigational Therapies;Keratin;Knowledge;Lead Poisoning;Light;Liver;Liver diseases;liver injury;Mediating;Methionine;methionine sulfoxide;methionine sulfoxide reductase;Microsomes;Molecular;Molecular Profiling;Molecular Weight;Monitor;monomer;mouse model;Mus;Mutation;novel;novel therapeutics;Organ;oxidation;Oxidative Stress;Oxidoreductase;Pathway interactions;Patients;Pharmaceutical Preparations;Photosensitivity;Pigments;Porphyrias;Porphyrins;pre-clinical;preclinical study;Predisposition;prevent;Propionates;protein aggregation;Proteins;Proteomics;proteotoxicity;protoporphyrin IX;Reactive Oxygen Species;repaired;Role;Skin;small molecule;Sodium Dodecyl Sulfate;success;succinyl-coenzyme A;Technology;Testing;Therapeutic;tissue injury;Tissues;tool;Toxic effect;Toxin;Uroporphyrins;Work;Zebrafish

PROJECT_TITLE: Mechanism of Proteotoxicity and Experimental Therapeutic Approaches in Porphyria


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative The proposed study is highly significant and relevant to human health: (1) this study would provide better understanding of p53 biology and how p53-dependent tumor suppression is regulated by the Rbm38-eIF4E pathway; (2) This study would reveal whether the Rbm38-eIF4E pathway can be targeted to kill tumor cells carrying wild-type p53.

PI_NAMEs: CHEN, XINBIN  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Aspartic Acid;Binding;Biology;Canis familiaris;Cell Aging;cell growth;Cell Line;Cells;Cessation of life;Charge;Complex;Databases;DNA Damage;Exposure to;Feedback;Genes;Health;Human;Hydrogen Bonding;in silico;In Vitro;in vivo;in vivo Model;Knock-in;Knock-in Mouse;Large Intestine Carcinoma;Lymphoma;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Messenger RNA;Modeling;Molecular;mouse model;mRNA Translation;Mus;mutant;Mutate;Mutation;neoplastic cell;Oncogenes;Pathway interactions;Peptides;Phosphorylation;Play;Premature aging syndrome;prevent;Regulation;Repression;response;RNA-Binding Proteins;Role;screening;sensor;Series;Serine;Signal Transduction;simulation;Stress;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Agents;TP53 gene;transcription factor;Translations;tumor progression;Tumor Suppression;Tumor-Derived;Variant

PROJECT_TITLE: Mechanism of p53-dependent Tumor Suppression

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Sleep Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Out of all daily experiences, salient ones are likeliest to leave long-lasting memories, yet the neural mechanisms underlying the preferential transformation of salient experiences into long- term memories are poorly understood. Dopaminergic neurons in the ventral tegmental area (VTA-DA) are critically involved in online salience coding, yet their role in offline consolidation of these experiences into long-term memory is considerably less understood. The proposed research will address this knowledge gap utilizing optical and electrophysiological recordings of neural activity and closed-loop manipulations of specific neural circuits in freely behaving, learning and sleeping mice.

PI_NAMEs: EBAN-ROTHSCHILD, ADA  (contact);ROTHSCHILD, GIDEON

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Amygdaloid structure;Anatomy;Aversive Stimulus;Axon;Behavioral;Binding;Brain region;cell type;Cells;Code;cognitive function;Communication;Computer Analysis;Cues;Data;Data Reporting;Dependence;Development;Dopamine;dopaminergic neuron;Electrophysiology (science);Event;experience;experimental study;Fiber;Food;Fright;Head;Hippocampus;insight;Knowledge;Learning;long term memory;Memory;memory consolidation;Memory impairment;memory recall;Mental disorders;Microscope;Molecular;Mus;Nature;Negative Valence;neural;neural circuit;neuromechanism;Neurons;novel therapeutic intervention;Nucleus Accumbens;Optics;optogenetics;pharmacologic;Photometry;Physiological;Population;Positive Valence;Process;Reporting;Research;Resolution;Rewards;Role;Sensory;Signal Transduction;Sleep;Stimulus;Structure;Testing;Ventral Tegmental Area

PROJECT_TITLE: The functions of dopamine signaling during sleep in memory

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Personalized, adaptive, brain stimulation has the potential to benefit disabling behavioral symptoms such as apathy and impulsivity across a wide range of neurological conditions, including Parkinson’s disease, but is currently limited by a lack of understanding of how the brain assesses rewards to drive actions. The goal of this project is to determine how rewards are evaluated across the frontal cortex - basal ganglia circuits and to evaluate the mechanistic role of the structures and signals of this network in Parkinson’s disease. This foundational understanding will direct future stimulation therapies to reduce the burden of apathy and impulsivity in Parkinson’s disease and other neurological disorders in a precise and principled manner.

PI_NAMEs: LITTLE, SIMON  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: addiction;Address;affective neuroscience;Alzheimer's Disease;Award;Basal Ganglia;Behavior;Behavior Disorders;Behavior Therapy;Behavioral;Behavioral Symptoms;Biometry;Brain;Characteristics;Chronic;Clinical;Cognitive;cohort;cost;Cost Analysis;Costs and Benefits;Craniocerebral Trauma;Decision Making;Deep Brain Stimulation;Development;Diagnostic;Disabling;Disease;Dopamine;Educational Curriculum;effective therapy;Electrocorticogram;Electrodes;Epilepsy;Evaluation;experimental study;Foundations;Frequencies;frontal lobe;Frontotemporal Dementia;Future;Ganglia;Goals;Home;Human;Huntington Disease;Implant;Impulsivity;indexing;innovation;Intervention;Investigation;Knowledge;Laboratories;Link;Machine Learning;Mediating;Mental Depression;Mentors;motivated behavior;Motivation;Motor;Motor Cortex;motor symptom;multidisciplinary;Nervous System Disorder;neural;neural circuit;neural stimulation;Neurologic;Neurologic Symptoms;neurophysiology;neurotransmission;non-motor symptom;novel;Parkinson Disease;Patient Self-Report;Patients;personalized medicine;Pharmaceutical Preparations;Prefrontal Cortex;Quality of life;Reproducibility;Research;reward circuitry;Rewards;Role;Schizophrenia;Self Assessment;Signal Transduction;spatiotemporal;Specific qualifier value;statistics;Stroke;Structure;symptomatology;Symptoms;System;Techniques;Testing;Training;trial design;Work

PROJECT_TITLE: Uncovering the neurophysiology of motivation in ParkinsonÃÂs disease with implanted adaptive brain stimulation

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Lung

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The goal of this proposal is to investigate differences in disease phenotype and disease progression in a larger cohort of subjects with sporadic inclusion body myositis subjects, including muscle pathology, and to examine if a set of blood and skeletal muscle-based biomarkers influence the disease behavior. These biomarkers include antibodies to the NT5c1A antigen as well as variant T-lymphocyte population in blood and muscle. Furthermore, we would like to continue to examine the distribution of Kv1.3 potassium channels in blood and muscles to see if it can potentially be targeted by pharmacological agents. Knowledge of this will help us design more effective and efficient clinical trials in IBM using newer generation immunosuppressive agents. Upon completion of these aims, we will 1) understand the disease phenotype, including pattern of respiratory involvement, and disease progression in sIBM better and understand the influence of serum antibodies to NT5c1A antibodies on the natural history and disease behavior; 2) define differences in serum variant T-cells and cytokine signatures in sIBM patients and their influence on disease progression and behavior; and 3) understand muscle pathology and immune cell distribution in sIBM patients and its relationship to NT5c1A antibodies. These findings may influence future trial design in sIBM. Finally, we will have created a thirteen-site consortium of myositis treatment centers that will be ready to adopt quickly any future clinical trials aimed at changing the course of sIBM.

PI_NAMEs: MOZAFFAR, TAHSEEN  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Address;Adopted;aging related disease;American;Antibodies;Antigens;Apoptosis;Behavior;Biological Markers;Biopsy Specimen;Blood;CD44 gene;Cells;clinical phenotype;Clinical Trials;cohort;Communities;community engagement;cytokine;cytotoxic;Data;design;Development;disability;Disease;disease natural history;disease phenotype;Disease Progression;Enrollment;Evaluation;follow-up;Frequencies;Future;Generations;Geographic Locations;Goals;Histology;human old age (65+);Immune;Immunohistochemistry;Immunologics;Immunophenotyping;Immunosuppressive Agents;Institutional Review Boards;interest;Knowledge;Kv1.3 potassium channel;Lymphocyte;Lymphocyte Subtypings;Measures;Mediating;Molecular;Morbidity - disease rate;Morphology;Muscle;Muscle Weakness;Myositis;Natural History;Natural Killer Cells;Observational Study;Pathology;patient subsets;Patients;Pattern;pharmacologic;Population;Prevalence;prospective;Prospective Studies;Rare Diseases;Resistance;Respiration Disorders;respiratory;Respiratory Failure;Respiratory Insufficiency;Respiratory physiology;Serology;Serum;Severity of illness;Site;Skeletal Muscle;Sleep Apnea Syndromes;Sporadic Inclusion Body Myopathy;Subgroup;Surveys;T-Lymphocyte;targeted treatment;Time;treatment center;trial design;United States;Variant;willingness

PROJECT_TITLE: Influence of NT5c1A antibodies on disease progression, clinical phenotype and blood and muscle biomarkers in sporadic Inclusion Body Myositis - A prospective evaluation

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Precision Medicine;Rehabilitation;Substance Misuse

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The opioid epidemic is an urgent public health problem in the United States. This project aims to leverage existing clinical trial data to identify predictors of response to behavior therapy for opioid use disorder. The potential public health impact of this study is to inform personalized medicine approaches to the treatment of opioid use disorder.

PI_NAMEs: MCHUGH, REBECCA KATHRYN (contact)

PROGRAM_OFFICER_NAME: AKLIN, WILL

PROJECT_TERMS: Address;Age;Area;Behavior Therapy;Buprenorphine;buprenorphine treatment;chronic pain;Clinical;clinical care;Clinical Treatment;Clinical Trials;cocaine use;Cognitive Therapy;Combined Modality Therapy;Common Data Element;Counseling;Data;Data Analyses;data harmonization;Data Set;Decision Making;Drops;Drug Screening;effective therapy;efficacy testing;Employment;Engineering;Epidemic;Family;Functional impairment;functional improvement;functional outcomes;Funding;Future;heroin use;Heterogeneity;Impairment;improved;Individual;innovation;interest;Knowledge;Legal;Maintenance;Manuals;Measures;medication for opioid use disorder;Medicine;Mental disorders;Methodology;Methods;National Institute of Drug Abuse;non-opioid analgesic;novel;Opioid;Opioid Analgesics;opioid epidemic;opioid misuse;opioid overdose;opioid use;opioid use disorder;Outcome;overdose death;Participant;Patient Self-Report;patient subsets;Patients;personalized approach;personalized medicine;Persons;Pharmaceutical Preparations;predicting response;primary outcome;Public Health;randomized trial;randomized, clinical trials;Relapse;Reporting;Research;response;Review Literature;Role;Sample Size;Sampling;secondary analysis;Structure;Subgroup;substance use;Substance Use Disorder;systematic review;Testing;treatment effect;treatment response;United States;United States National Academy of Sciences;Update;Urine;Work

PROJECT_TITLE: The Role of Behavior Therapy Combined with Buprenorphine for the Treatment of Opioid Use Disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Cardiovascular toxicity presents a significant problem for cancer therapy, as the adverse effects often interfere with the treatments and compromise patients' long-term survival. This proposal will interrogate the interplay between genetic variants in the etiology of doxorubicin-induced cardiotoxicity by employing the iPSC-CM “cell village” platform coupled with engineered heart tissue, scRNA-seq, scATAC-seq, and CRISPR/Cas9 genome editing technologies. The knowledge we collect here with the “cell village” model should be instrumental in interrogating interindividual susceptibility at a large-scale and high throughput fashion.

PI_NAMEs: MERCOLA, MARK ;WU, JOSEPH C. (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: 3-Dimensional;Adverse effects;Affect;Aging;Alleles;Biological Process;Calcium;cancer complication;cancer therapy;Cardiac Myocytes;cardiac tissue engineering;Cardiotoxicity;Cardiovascular Diseases;Cardiovascular system;Cell Line;Cell Survival;Cells;Chromosome Mapping;Circulation;Coculture Techniques;Coupled;CRISPR/Cas technology;cytotoxic;differentiation protocol;DNA Damage;dosage;Dose;Doxorubicin;Drug Screening;epigenome;Etiology;experimental study;Exposure to;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;genetic variant;genome editing;genome sequencing;genome-wide;Genotype;Grant;Heart;Hour;human induced pluripotent stem cells;Individual;Individual Differences;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;inter-individual variation;Journals;Knowledge;Maps;Methodology;Modeling;multiple omics;Nature;novel;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Preparations;Population Heterogeneity;precision drugs;Predisposition;Production;Publishing;Quantitative Trait Loci;RARG gene;Research Personnel;response;Risk;Role;Series;single cell analysis;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Stains;stem cells;Technology;Time;Toxic effect;Transcription Initiation Site;transcriptome;whole genome;XCL1 gene

PROJECT_TITLE: Single-cell Multi-omic Profiling of Drug Responses Using Pooled iPSC-CM Differentiation

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Estrogen;Heart Disease;Menopause;Nutrition;Prevention;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative: ASCVD progresses with aging and causes one-third of deaths worldwide. The protection in females against ASCVD is lost in postmenopausal women and has not been replicated in clinical trials, in part because the mechanisms are not completely understood. By using animal models of surgical menopause and hormone therapy overlayed with bone marrow transplant techniques, this project will define a novel mechanism to provide a platform for developing therapeutic methods to replicate the protection of sex hormones against ASCVD.

PI_NAMEs: ZHU, LIN  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Academic Medical Centers;aged;Aging;aging related;Animal Model;Arterial Fatty Streak;Arteries;Atherosclerosis;Blood;blood lipid;Bone Marrow;Bone Marrow Transplantation;cardiovascular disorder risk;Cardiovascular system;career;career development;Cell Aging;Cell Physiology;Cessation of life;Clinical;Clinical Trials;Competence;Data;design;Development Plans;Diet;Drops;Dyslipidemias;Endothelium;Estradiol;Estrogens;Event;experience;Faculty;feeding;Female;Functional disorder;Goals;Gonadal Steroid Hormones;Homeostasis;hormone therapy;Hyperlipidemia;Immune;Immunofluorescence Immunologic;Impairment;improved;In Vitro;in vivo;indexing;Inflammation;Inflammatory;Insulin;Interferon Type II;Interferons;Knowledge;Leadership;Lesion;lipid metabolism;Lipids;Liver;Mediating;men;menopausal hormone therapy;Menopause;Mentorship;Metabolic;Methods;mouse model;Mus;novel;Older Population;older women;Ovariectomy;Ovary;Paper;Pathway interactions;Physicians;Physiology;Positioning Attribute;Postmenopause;Premenopause;prevent;Prevention;Publishing;reconstitution;Regulation;repaired;Reporting;Research;Research Design;Research Personnel;Resolution;Risk;Role;Safe Sex;Scientist;senescence;senescent cell;Sex Differences;Signal Transduction;skills;Stains;stem cells;surgical menopause;Techniques;tenure track;Testing;Therapeutic;Training;Translational Research;Transplantation;western diet;Woman;women's clinical trial;young woman

PROJECT_TITLE: Does Senescence Impair the Cardiovascular Benefits of Menopause Hormone Therapy?

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Infectious Diseases;Precision Medicine

ORG_CITY: AMES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE We will generate a human RNA structure-omics signature using bioinformatics and cheminformatics tools to determine and validate RNA targets for small molecule drug design. These studies will expand the druggable human genome by delivering a comprehensive map of targetable RNA structures and determine an efficient path to annotate the transcriptome in disease-associated pathways. These approaches will broadly enable the design of precision medicines and chemical probes for RNA targets previously thought to be “undruggable”.

PI_NAMEs: ROUSE, WARREN B (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: 2019-nCoV;Algorithms;alpha synuclein;Archives;Area;bench to bedside;Binding;Binding Sites;Biochemical;Bioinformatics;Biological Assay;Biology;Bypass;Cell Line;Chemicals;cheminformatics;Code;Collection;comparative;Computer software;Data;Databases;design;Disease;disease model;drug action;drug candidate;Drug Design;drug discovery;Drug Targeting;DU145;Elements;Engineering;Gene Expression;Genes;Genetic Diseases;Genome;Health;Human;Human Genome;human pathogen;improved;Infection;innovation;insight;interest;intermolecular interaction;Knowledge;KRAS2 gene;Laboratories;Malignant Neoplasms;Maps;Messenger RNA;Methods;Modeling;Mosses;novel;novel therapeutics;nuclease;Oncogenes;Outcome;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;precision medicine;predictive modeling;Probability;programs;protein function;Proteins;Proteome;recruit;Research;Research Personnel;Resources;RNA;RNA Binding;RNA Probes;RNA Viruses;RNA-targeting therapy;Role;small molecule;Specificity;Stress;Structure;synergism;targeted treatment;tau Proteins;Testing;Therapeutic;Therapeutic Intervention;therapeutic lead compound;tool;Transcript;transcriptome;Translating;Untranslated RNA;Validation;vertebrate genome

PROJECT_TITLE: Expanding the Druggable Human Genome


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Serious Mental Illness

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) can develop following exposure to stress and trauma. However, there are no biological tests for diagnosis of either disorder. Our proposal will identify brain network disruptions in PTSD and MDD as well as identify new previously unrecognized subtypes of MDD and PTSD, which will help advance research for new treatments.

PI_NAMEs: MOREY, RAJENDRA A (contact);SCHMAAL, LIANNE

PROGRAM_OFFICER_NAME: TUMA, FARRIS KEITH

PROJECT_TERMS: Age;algorithm training;Algorithms;Arousal;Attention;Behavior;biobank;Biological Testing;biotypes;Brain;brain circuitry;brain dysfunction;Brain region;Categories;Characteristics;Chronic;Classification;Clinical;cohort;Collaborations;comorbidity;Control Groups;Coupled;Data;Data Set;depressive symptoms;Development;Diagnosis;Diagnostic;Dimensions;Disease;disease classification;disease model;Dorsal;effective therapy;experience;Exposure to;Fright;Functional Magnetic Resonance Imaging;Future;Gender;Goals;Heterogeneity;Hybrids;Individual;Infrastructure;interest;large datasets;learning strategy;Life Stress;Major Depressive Disorder;Maps;Medical;Mental disorders;Modeling;Modernization;neural;neural circuit;neurobiological mechanism;Neurobiology;neuropsychiatric symptom;novel;Participant;patient subsets;Patients;Pattern;pediatric trauma;Population;Post-Traumatic Stress Disorders;precision medicine;psychiatric comorbidity;psychological trauma;Recording of previous events;Research;Research Domain Criteria;Resources;Rest;reward processing;Sampling;Severity of illness;Sleep disturbances;Stress;Stressful Event;supervised learning;symptom cluster;Symptoms;Syndrome;Technology;Testing;therapy design;Time;translational neuroscience;Trauma;trauma exposure;unsupervised learning

PROJECT_TITLE: Neurobiologically-Based Subtyping of Multi-Cohort Samples with MDD and PTSD Symptoms

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Hematology;Infectious Diseases;Neurodegenerative;Sepsis

ORG_CITY: LEXINGTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE This project is relevant to public health because it will enhance our understanding of the mechanisms for long- term cognitive impairment among millions of people who survived sepsis. Obtained information will allow us to elucidate a novel preventive strategy which would help sepsis survivors to return to a more productive and fulfilling lifestyle.

PI_NAMEs: SAITO, HIROSHI  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acute;age related;Alzheimer's Disease;Animal Model;Animals;Antibiotic Therapy;Antibiotics;apolipoprotein E-3;apolipoprotein E-4;Brain;brain tissue;cecal ligation puncture;Cecum;Cells;Chronic;clinically relevant;cognitive enhancement;cognitive testing;Critical Illness;Defect;Delirium;Dementia;Disease susceptibility;Elderly;Enzymes;Exhibits;Functional disorder;Genes;Genetic Polymorphism;Genotype;Goals;high risk;Hospitals;Human;Impaired cognition;Incidence;Infection;Inflammation;Injections;Knock-in;Knock-in Mouse;Laboratory Animal Models;Life;Life Style;Ligation;Liquid substance;Long-Term Effects;Longitudinal Studies;Medical;Memory;Memory impairment;middle age;Mitochondria;mitochondrial dysfunction;Modeling;mortality;mouse model;Mus;Muscle;Muscle Weakness;Mutant Strains Mice;Necrosis;Neurons;novel;object recognition;old mice;Operative Surgical Procedures;Pathology;Patients;Persons;Population;Predisposition;prevent;Prevention strategy;Procedures;Productivity;Protocols documentation;Public Health;Publishing;Quality of life;Recovery;Reporting;Research;Resuscitation;Risk Factors;Sepsis;Skeletal Muscle;skeletal muscle weakness;Stains;Survivors;Swimming;systemic inflammatory response;Testing;transcriptome sequencing;Transmission Electron Microscopy;Wild Type Mouse;young adult

PROJECT_TITLE: A Refined Murine Model of Post-sepsis Cognitive Impairment for Investigating Mitochondrial Abnormalities and Human ApoE4 Gene Polymorphisms

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Public Health Statement Traumatic brain injury (TBI) remains a public health concern, the consequences of which can lead to long-lasting disability and cognitive dysfunction. Unfortunately, the neural mechanism underlying memory dysfunction in the chronic stage of injury and effective strategies to improve learning and memory are not available. The present proposal will investigate if stimulation of hippocampal neuron and/or administration of specific drugs can be used to improve hippocampal place cell function and memory after TBI.

PI_NAMEs: DASH, PRAMOD K (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Abbreviations;Acute;Animals;Area;Back;Brain Concussion;Brain Injuries;Brain region;Cell Physiology;Cells;Cessation of life;Chemosensitization;Chronic;Cues;Cyclic AMP-Responsive DNA-Binding Protein;disability;Disinhibition;DUSP6 protein;Electrodes;Electrophysiology (science);enhancing factor;Environment;Event;Experimental Models;experimental study;extracellular;Failure;fluid percussion injury;Frequencies;functional improvement;Gene Expression;Genetic;hippocampal pyramidal neuron;Hippocampus;Human;Immunohistochemistry;Impaired cognition;Impairment;improved;improved outcome;in vivo;inhibitory neuron;Injury;Interneurons;Lateral;Learning;Link;long term memory;Medial;Medial Septal Nucleus;Memory;Memory impairment;mild traumatic brain injury;Modality;Molecular;neural;neural circuit;neuromechanism;neuron loss;Neuronal Plasticity;neuronal survival;Neurons;Neurophysiology - biologic function;neuroprotection;optogenetics;Parvalbumins;Patients;Pattern;Periodicity;Persons;Pharmaceutical Preparations;pharmacologic;phosphodiesterase 4D;Phosphorylation;place fields;Play;prevent;Property;Protein Biosynthesis;Protein Kinase;Public Health;Rattus;Role;Sensory;Somatostatin;Synaptic plasticity;Testing;Theta Rhythm;Time;transcription factor;Transcriptional Activation;Traumatic Brain Injury

PROJECT_TITLE: Enhancing the function of hippocampal neurons after TBI

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative: Deficits in olfaction are long-established symptoms of Alzheimer’s Disease whose potential to reveal mechanisms leading to this disease has yet to be realized. Recent evidence that the olfactory epithelium and its olfactory sensory neurons are vulnerable to genetic variants linked to Alzheimer’s Disease open opportunities to investigate early effects leading to neurodegeneration in a neural tissue that is easily accessible, including via biopsy in humans. This project investigates the effects of human apoliproprotein E alleles on the olfactory epithelium and its neurons in mouse models, including whether switching expression from a neurodegenerative allele to a neuroprotective allele prevents and reverses effects linked to Alzheimer’s Disease.

PI_NAMEs: MCCLINTOCK, TIMOTHY S (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Adult;Affect;Age;age effect;age related;age-related disease;Alleles;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Autopsy;Biopsy;Blood - brain barrier anatomy;Brain;cell type;Cells;Central Nervous System;Characteristics;Chronic;Complex;Data;Data Correlations;Development;Diagnosis;Disease;disease model;Disease Progression;Early identification;Epithelium;Event;experimental study;Foundations;Gene Expression;gene therapy;Genetic;genetic manipulation;Genetic Models;genetic variant;Genotype;Glucose;glucose uptake;Goals;Human;Human Amyloid Precursor Protein;Immune response;improved;in vivo;in vivo Model;Individual;Intervention;Late Onset Alzheimer Disease;Learning;Link;lipidome;MAPT gene;Measures;Messenger RNA;Metabolic dysfunction;Microglia;middle age;Modeling;Molecular;mouse model;Mus;mutant;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuron apoptosis;neuronal survival;Neurons;neuroprotection;novel;Olfactory Epithelium;Olfactory Pathways;olfactory sensory neurons;Outcome;Pathologic;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Predisposition;prevent;Probability;protective effect;Proxy;Publishing;Regenerative capacity;Research;response;Risk Factors;Risk Reduction;single-cell RNA sequencing;Site;slow axonal transport;Smell Perception;Stress;success;Supporting Cell;sustentacular cell;Symptoms;synergism;Testing;therapy design;Tissues;transcriptome;Work;young adult

PROJECT_TITLE: Olfactory Epithelium Responses to Human APOE Alleles

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_DEPT: PHARMACOLOGY

ORG_STATE: SC

PHR: Project Narrative Periodontal disease affects 42% of adult Americans, yet there are no effective adjunctive treatment options following traditional non-surgical or surgical intervention. To date, the epigenetic mechanisms that govern periodontal health and disease are not well defined. The research outlined in this proposal will identify major epigenetic mechanisms engaged in periodontal disease progression and target these processes for the design of novel chemical probes and therapeutic agents.

PI_NAMEs: PETERSON, YURI KARL (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Actinobacillus actinomycetemcomitans;Active Sites;Adjuvant Therapy;Adult;Affect;American;analog;Attenuated;Automobile Driving;Biochemical;bone loss;Calvaria;Chemicals;Chromatin;chromatin remodeling;Clinical;Collection;computational chemistry;Connective Tissue Diseases;CRISPR/Cas technology;cytokine;Data;demethylation;design;Development;Disease;Disease Progression;Docking;Drug Design;Drug Targeting;Enzyme Kinetics;Enzymes;Epigenetic Process;experimental study;Family;Fostering;Genetic Transcription;Goals;Health;Health Sciences;Hematoxylin and Eosin Staining Method;high throughput screening;histological stains;histone demethylase;Histones;Human;Immune response;immunoregulation;in silico;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory bone loss;Inflammatory Infiltrate;Inflammatory Response;inhibitor;Interleukin-6;KDM1A gene;Knock-out;Knowledge;lead optimization;Libraries;Ligature;Lipopolysaccharides;Lysine;Macrophage;Maps;Maximum Tolerated Dose;Measures;meetings;microCT;Modeling;Modification;Mus;novel;novel therapeutics;Operative Surgical Procedures;Oral health;osteoclastogenesis;Osteoclasts;osteoimmunology;overexpression;Pathogenesis;Pathologic;Patients;Periodontal Diseases;Periodontic specialty;Periodontitis;periodontopathogen;pharmacophore;Phenotype;Play;Population;prevent;Process;Production;progression marker;Proteins;Research;response;Role;Sampling;scaffold;side effect;small molecule;Source;South Carolina;Structure;Surface Antigens;System;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Tissues;TNF gene;tool;Toxic effect;trimethyllysine

PROJECT_TITLE: Mechanistic probes to study the immune response in periodontal disease


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Coronaviruses;Health Services;Networking and Information Technology R&D (NITRD)

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE Healthcare provider (such as dialysis facilities and transplant centers) profiling is of nationwide importance. The statistical analysis along with further reviews may lead to changes in budgeting allocations and even suspension for providers with extremely poor outcomes. Existing profiling approaches typically assume that the risk adjustment is perfect, and the between-provider variation is entirely due to the quality of care, which, however, is often invalid. In addition, analyzing large-scale databases introduces computational difficulties, particularly when the event of interest is recurrent, and the numbers of sample size and the dimension of parameters are large. How to integrate streaming recurrent event data adds another level of difficulty. In view of these difficulties. Finally, the COVID-19 pandemic has dramatically changed how healthcare care is delivered. It is crucial that the profiling methods account for temporal and geospatial variation and accurately evaluate providers’ performance during the pandemic. Our proposed methods address these statistical challenges and, in broader applications, will advance the development of quality control procedures and support better-informed healthcare policy decisions.

PI_NAMEs: HE, ZHI KEVIN (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Address;Advanced Development;Algorithms;Budgets;Caring;Certification;Cessation of life;clinical application;comorbidity;comorbidity Index;Computer software;Computing Methodologies;cost;COVID-19 pandemic;COVID-19 prevalence;Data;data registry;Data Set;data streams;Databases;design;Detection;Dialysis procedure;Dimensions;discrete time;Discrimination;End stage renal failure;Event;Evolution;Family;Goals;Government;Grant;health assessment;Health Personnel;Health Policy;Healthcare;Healthcare Systems;high dimensionality;Hospitalization;improved;innovation;interest;large-scale database;Measures;Medicare;Methodology;Methods;Modeling;Monitor;mortality;multiple data sources;novel;open source;Outcome;pandemic disease;parallel computer;Patient-Focused Outcomes;Patients;Performance;Physicians;Play;Privatization;Procedures;Provider;Publications;Quality Control;Quality of Care;Recurrence;Research;Research Personnel;Risk;Risk Adjustment;Role;Sample Size;Saran;Speed;Statistical Data Interpretation;Statistical Methods;Stream;Subgroup;Suspensions;Techniques;Testing;theories;Time;transplant centers;Transplant Surgeon;United States Centers for Medicare and Medicaid Services;Update;Variant;Writing

PROJECT_TITLE: Improve Statistical Methods for Profiling of Healthcare Providers

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE  Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with a low survival rate and limited treatment options. Pilot studies reveal that the tumor suppressive activities of type 1 interferon (IFN1) cytokines against development and progression of PDA are undermined by pancreatic inflammation, which downregulates the IFN1 receptor IFNAR1 and also disarms pathway effectors downstream of IFNAR1. Studies proposed here will determine the importance of the IFN1-IFNAR1 pathway in PDA, delineate the mechanisms of inactivation of this pathway during PDA development and progression and potentially pave the road to novel therapies aimed to re- activate downstream targets of IFNAR1.

PI_NAMEs: FUCHS, SERGE Y (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: 25-hydroxycholesterol;Ablation;Adjuvant Therapy;Agonist;Angiogenesis Inhibition;Apoptosis;cancer cell;Cancer Etiology;Cell Aging;Cell surface;cell transformation;Cells;Cessation of life;chemotherapy;Cholesterol;chronic pancreatitis;conditional knockout;cytokine;Data;Development;Disease;Down-Regulation;Enzymes;Etiology;Future;Genetic;genetic approach;Growth;Human;IFNAR1 gene;Immunocompetent;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;Interferon alpha;Interferon Receptor;Interferon Type I;Interferons;Ligands;Liver X Receptor;Mediating;Metabolic;metastatic process;Mixed Function Oxygenases;Modeling;mouse model;Mus;mutant;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenes;Organoids;Outcome;Pancreas;pancreas development;Pancreatic Adenocarcinoma;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathogenesis;Pathway interactions;Phosphorylation;Phosphotransferases;Pilot Projects;preclinical study;Production;Proliferating;Public Health;Radiation therapy;receptor;Regimen;Reporting;response;Role;senescence;Signal Transduction;Stimulus;Stress;Survival Rate;targeted agent;Testing;Tissues;treatment response;tumor;Tumor Immunity;tumorigenic;Ubiquitination;United States

PROJECT_TITLE: Type I Interferon Pathway in Pancreatic Adenocarcinoma


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Substance Misuse

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative People infected with human immunodeficiency virus (HIV-1) can successfully control their infection with current antiretroviral therapies, but roughly half of treated patients present with a range of cognitive impairments referred to as HIV-associated neurocognitive disorder (HAND). Researchers have long studied the underlying bases of this disorder using animal and cellular model systems, which have provided important insights into the underlying pathology but have not yet led to an effective therapy for patients. Since these models may incompletely reflect the disease in humans, this project proposes to develop a human brain slice culture of HIV infection and antiretroviral treatment, which will better reflect today’s adult human patients and provide a platform to study the mechanisms leading to HAND and novel therapeutic approaches.

PI_NAMEs: JACKSON, JOSHUA GOODYEAR;KLASE, ZACHARY ALAN;MEUCCI, OLIMPIA  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Adjuvant Therapy;Adult;Affect;Animal Model;Animals;Anti-Retroviral Agents;antiretroviral therapy;Architecture;Astrocytes;automated analysis;Automobile Driving;base;Behavioral Symptoms;Biological Models;Blood donor;Blood specimen;Brain;brain surgery;brain tissue;Calcium;Calcium Signaling;Cell model;Cell Survival;cell type;Cells;Central Nervous System;Central Nervous System Infections;Cerebral cortex;Cerebrospinal Fluid;Characteristics;clinical investigation;Clinical Research;Clinical Trials;Collaborations;Communication;comorbidity;Computer software;confocal imaging;Confocal Microscopy;Culture Media;Dendritic Spines;density;Disease;Dissociation;drug action;Drug toxicity;effective therapy;Encephalitis;Environment;Evaluation;Excision;Experimental Models;Exposure to;Flow Cytometry;fluorescence imaging;Fostering;Foundations;Future;Genetic;glutamatergic signaling;Glutamates;Heterogeneity;HIV;HIV Infections;HIV Seronegativity;HIV-associated neurocognitive disorder;Human;human model;human tissue;Image;Image Analysis;Impaired cognition;Impairment;Individual;Infection;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;insight;Label;Life;life span;Longitudinal Studies;Macrophage;Measures;Mediating;Modeling;Molecular;Monitor;monocyte;Morphology;motor symptom;multi-electrode arrays;neuroAIDS;Neurobehavioral Manifestations;Neuroimmune;neuroinflammation;neuron loss;neuronal circuitry;Neurons;Neuropathogenesis;neuropathology;neuroprotection;Neurosurgeon;neurotransmission;novel therapeutic intervention;older patient;Operative Surgical Procedures;pandemic disease;Pathologic;Pathology;Pathway interactions;Patients;peripheral blood;Persons;Pharmaceutical Preparations;Pre-Clinical Model;preclinical study;Preclinical Testing;preservation;Property;Regimen;Research;Research Personnel;Scientist;Signal Transduction;Sister;Slice;Stains;standard of care;Structure;Substance Use Disorder;System;Techniques;Thick;tissue culture;Tissue Donors;Tissues;Vertebral column;Viral;Virus Replication;Vulnerable Populations

PROJECT_TITLE: Adult human brain tissue cultures to study neuroHIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Natural Products

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Relevance to Public Health:  At the core of chemistry lies the power to manipulate the elements for the preparation of specific arrays of atoms in a predictable and reliable fashion. As synthetic chemists, our ability to construct molecules with exquisite precision is unique within the sciences. In this proposal, we outline broad approaches toward the construction of important linkages and describe the implemention of these methods in highly complex situations relevant to human medicine.

PI_NAMEs: STOLTZ, BRIAN M (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: The Synthesis of Bioactive Natural Products as a Driving Force for Discovery in Organic Chemistry


NIH_SPENDING_CATS: Cardiovascular;Diabetes;Hypertension

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Hypertension, vascular disease and endothelial dysfunction drive heart disease and are major health concerns in today’s society. The proposed research is relevant to the mission of the NHLBI because it examines novel molecular mechanisms of the LRRC8 signaling complex endothelial function. Exploring this novel pathway and intracellular signaling mechanism will expand our understanding of innovative therapeutic avenues for the treatment and prevention vascular diseases and heart disease.

PI_NAMEs: DIWAN, ABHINAV ;SAH, RAJAN  (contact);STRATMAN, AMBER NICOLE

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: angiogenesis;Angiotensin II;Anions;Biochemical;Biology;Blood flow;Blood Pressure;Blood Vessels;Cell membrane;Cell Physiology;Chemicals;Chronic;Complex;Data;detection of nutrient;Diabetes Mellitus;diabetic;Diffuse;Disease;Endothelial Cells;Endothelium;Exhibits;experimental study;fluid flow;FRAP1 gene;genome wide association study;Health;Heart Diseases;Human;Human Genome;Hydrostatic Pressure;Hypertension;Image;Impairment;improved;In Vitro;in vivo;Infusion procedures;innovation;Knockout Mice;Knowledge;Laboratories;Leucine-Rich Repeat;Lysosomes;Mechanics;Metabolic syndrome;Mission;Modeling;Molecular;Molecular Biology;Mus;Mutation;National Heart, Lung, and Blood Institute;Non-Insulin-Dependent Diabetes Mellitus;novel;patch clamp;Pathway interactions;pharmacologic;phenome;PIK3CG gene;pre-clinical;Prevention;Proteins;Proto-Oncogene Proteins c-akt;Reagent;Regulation;Reporting;Research;response;Retina;Signal Transduction;small molecule;Societies;Stretching;Testing;Therapeutic;Treatment Efficacy;Umbilical vein;Vascular Diseases;vascular endothelial dysfunction;Vascular Endothelium-Dependent Relaxation

PROJECT_TITLE: LRRC8 complex regulation of endothelial function

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Exposure to interparental conflict is a leading risk factor for children who experience parental divorce and research suggests that children’s effective coping is a malleable protective mechanism to prevent mental health problems for these children. However, no existing evidence-based prevention programs have been shown to be effective in helping children cope with the uncontrollable stressor of interparental conflict following divorce. The proposed project will use user-centered design strategies to inform the development of intervention components designed to improve children’s effective coping to reduce mental health problems in children from high conflict divorced families and then a factorial optimization trial to assess effects of the coping intervention components.

PI_NAMEs: O'HARA, KAREY  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Age;Arizona;career;Child;Child Health;Child Mental Health;Clinical;Cognitive;Conflict (Psychology);coping;cost;cost effective;court;Data;design;Development;Discover, Design, Build, and Test Framework;distraction;Divorce;Ecological momentary assessment;Education;Educational workshop;Emotional;Evaluation;evidence base;experience;Exposure to;Family;Feedback;Focus Groups;Foundations;Goals;group intervention;high risk;improved;Individual;information gathering;Instruction;Intervention;intervention effect;intervention refinement;Interview;Investigational Therapies;Learning;Life;Link;longitudinal analysis;Measures;Mediating;Mediator;Mental disorders;Mental Health;Mentors;Mentorship;Methods;Modeling;Modernization;multiphase optimization strategy;National Institute of Mental Health;Online Systems;Outcome;Parents;Participant;preference;prevent;Prevention program;Preventive;Principal Investigator;Program Evaluation;programs;Psychology;psychosocial;Public Health;Quasi-experiment;Randomized, Controlled Trials;Relaxation;Research;Research Activity;Research Personnel;Research Project Grants;response;Risk Factors;Risk Reduction;satisfaction;Scientist;skills;Stress and Coping;stressor;success;Surveys;Testing;theories;therapy design;therapy development;Training;Training Activity;United States;Universities;usability;user centered design;Washington;web-based intervention;Work;X Inactivation

PROJECT_TITLE: Promoting effective coping by children exposed to post-divorce interparental conflict to reduce risk for mental health problems


ADMINISTERING_IC: DC

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

PHR: Stroke is the leading cause of adult disability in the United States; aphasia, an impairment of the ability to process language, is one of the most devastating results of left hemisphere stroke. The purpose of the work proposed here is to improve recovery from aphasia by expanding access to therapy by using telerehabilitation and by understanding the effects of drug therapy, brain health, and neurolinguistic factors on the outcome of aphasia therapy.

PI_NAMEs: FRIDRIKSSON, JULIUS  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acute;Address;Adult;Affect;Age;Anodes;Aphasia;aphasia recovery;Area;Behavioral;Biography;Brain;brain health;brain tissue;Chronic;chronic stroke;Clinic;Clinical;Collaborations;Communication;Data;Data Collection;Data Set;disability;Double-Blind Method;double-blind placebo controlled trial;Double-blind trial;Drug usage;Education;Employment Opportunities;Enrollment;Escitalopram;Family;Financial Support;Friends;Funding;Goals;Health;Impairment;Improve Access;improved;improved outcome;Individual;Language;Language Disorders;language processing;Left;Lesion;Life Expectancy;machine learning method;Manuscripts;Maps;Measures;Microvascular Dysfunction;Modeling;neural;neuroimaging;neurophysiology;Neuropsychology;North America;Older Population;Outcome;outcome prediction;Patients;Peer Review;Persons;Pharmacotherapy;Phase;Phase I/II Clinical Trial;post stroke;Postdoctoral Fellow;Process;Production;programs;Public Health;Publications;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Research Project Grants;response;Severities;South Carolina;Speech;speech processing;Stroke;stroke incidence;stroke patient;stroke survivor;stroke-induced aphasia;success;Survival Rate;Symptoms;syntax;telerehabilitation;Testing;therapy outcome;Time;transcranial direct current stimulation;Translating;United States;Universities;Work;Writing

PROJECT_TITLE: Center for the Study of Aphasia Recovery (C-STAR)


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Public Health Statement Triple-negative breast cancer is an aggressive form of breast cancer with limited treatment strategies. We propose to study in depth mechanism of action of tumor-suppressive role of UBR7, a novel H2B ubiquitin ligase, in triple-negative breast cancer as well as identify potential therapeutic vulnerabilities imparted by its loss. Our work is expected to provide critical insights into the role of a new histone modifier in triple negative breast cancer, which could provide biological insights into role of epigenome in this deadly disease.

PI_NAMEs: RAI, KUNAL  (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: aggressive breast cancer;Alleles;Behavior;Binding Sites;Biological;BRCA1 gene;Breast;breast cancer metastasis;Cadherins;cancer subtypes;CDH13 gene;Cell Adhesion;Cell Line;Cell Physiology;Cells;ChIP-seq;Chromatin;chromatin modification;Clustered Regularly Interspaced Short Palindromic Repeats;conditional knockout;Data;Dependence;Development;Disease;DNA Methylation;Ectopic Expression;Enzymes;Epigenetic Process;epigenome;epigenomics;epithelial to mesenchymal transition;Epithelium;experimental study;Gene Expression;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;genome-wide;Guide RNA;Histone H2B;Histones;human model;In Vitro;inhibitor;insight;Investigation;Kinetics;knock-down;Length;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;MCF10A cells;Mediating;Mesenchymal;Methyltransferase;Modeling;Molecular;Molecular Mechanisms of Action;molecular phenotype;Molecular Profiling;molecular subtypes;Monoubiquitination;mouse model;Nature;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutic intervention;Pathway interactions;Pattern;pharmacologic;Pharmacologic Substance;PHD Finger;Phenotype;Population;Process;Proteins;Public Health;Regulation;Research Design;Role;Series;single-cell RNA sequencing;targeted treatment;Therapeutic;Therapeutic Intervention;transcriptome sequencing;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor progression;Tumor Suppressor Proteins;ubiquitin ligase;ubiquitin-protein ligase;Work

PROJECT_TITLE: Role of UBR7, a novel H2BK120 E3 ubiquitin ligase, in suppression of breast cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


PROJECT_TERMS: aphasia recovery;behavior test;Behavioral;Budgets;California;Charge;Clinical;clinical research site;Clinical Trials;Clinical Trials Network;Collection;Communication;Communities;Data;Data Collection;Data Coordinating Center;data management;Data Set;Databases;Ensure;Enzyme-Linked Immunosorbent Assay;Expenditure;Funding;Goals;Human Resources;Individual;Internet;Location;Magnetic Resonance Imaging;Medical;meetings;Mission;Monitor;National Institute on Deafness and Other Communication Disorders;Nervous System Disorder;neuroimaging;operation;Participant;Performance;Periodicals;Phase;Principal Investigator;Problem Solving;Productivity;Progress Reports;Quality Control;Research;Research Project Grants;Research Support;Role;Schedule;Services;Site;South Carolina;Stroke;success;support network;symposium;Teleconferences;Testing;Time;timeline;tool;Universities;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Herpes simplex virus type 1 (HSV-1) infects more than half the adult population of the United States and remains the most common cause of viral encephalitis and infectious blindness, yet the pathogenesis of these most severe manifestations remain unclear. We have identified leucine-rich repeat kinase 2 (LRRK2) as a novel pathogenic determinant of severe HSV-1 infection. We propose to determine how LRRK2 and the common LRRK2 mutation, G2019S, alter the innate immune response to HSV-1, expanding our understanding of severe herpesvirus pathology and finding novel therapeutic opportunities to ameliorate the most morbid outcomes caused by this ubiquitous virus.

PI_NAMEs: KARABA, ANDREW HOOVER (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Adult;Alleles;Bacterial Infections;Binding;Biometry;Blindness;career;career development;Cell Death;Cell Line;cell type;Cells;Central Nervous System;chemokine;Cornea;Crohn's disease;Cutaneous;cytokine;Data;Developed Countries;Development Plans;Disease;disease model;Encephalitis;Etiology;Eye;Family;Flow Cytometry;General Population;Genes;Herpes encephalitis;Herpes stromal keratitis;Herpesviridae;Herpesvirus 1;High Prevalence;Human;IL18 gene;Immune;immune activation;immune cell infiltrate;Immune response;Immunocompromised Host;Immunohistochemistry;Immunologics;Immunology;in vivo;Infection;Infection Control;Inflammasome;Inflammation;Inflammatory;Innate Immune Response;Innate Immune System;Integration Host Factors;Interleukins;Intervention;Knockout Mice;Knowledge;Learning;Leprosy;Lesion;Life;LRRK2 gene;Macrophage;Malignant Neoplasms;marenostrin;Measurable;Measures;Mediating;Mentorship;Modeling;Morbidity - disease rate;mortality;mouse LRRK2 protein;mouse model;Multiprotein Complexes;Mus;Mutagenesis;mutant;Mutation;Natural Immunity;neurotropic;neurotropic virus;novel;novel therapeutics;Organ Transplantation;Outcome;outcome disparities;Parkinson Disease;pathogen;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Population;Production;Regulation;Research;research and development;Research Personnel;response;Role;Severities;Signal Pathway;Signal Transduction;Simplexvirus;skills;Skin;stable cell line;System;Testing;Tissues;Training;Transfection;Transgenic Mice;United States;Vaccines;Viral;Viral Encephalitis;Viral Pathogenesis;Virulence;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Modulation of Herpes Simplex Virus Pathogenesis by Leucine Rich Repeat Kinase 2

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_DEPT: MISCELLANEOUS

PHR: PUBLIC HEALTH RELEVANCE: The Hopkins Population Center (HPC) supports the production of innovative, impactful research on the relationship of population dynamics to population health. HPC research supports the priorities of the Population Dynamics Branch of NICHD, especially focusing on reproductive health and maternal, child and family health and the consequences of poverty and inequality on population health and well-being. The HPC contributes to the development of public health interventions with population impact by supporting research into multi-level social determinants of health, and disseminates its findings broadly.

PI_NAMEs: CHEN, FEINIAN  (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Acceleration;Agreement;Applications Grants;Area;Award;career;Child Health;Collaborations;Communication;Communities;Conceptions;Creativeness;Data;Demography;Development;Discipline;Engineering;Ensure;Family;Family health status;Funding;improved;Incubated;Inequality;innovation;Institution;interest;Investments;Lead;Link;Maternal and Child Health;Maternal Health;Mentors;Methodology;Methods;mid-career faculty;National Institute of Child Health and Human Development;Personal Satisfaction;Pilot Projects;Policies;Population;Population Dynamics;population health;Population Sciences;Poverty;Poverty Areas;Production;Productivity;programs;Public Health;public health intervention;public health relevance;Recording of previous events;recruit;Reproductive Health;Research;Research Activity;research and development;Research Infrastructure;Research Project Grants;Research Support;Role;Schools;Science;service organization;Services;sexual and reproductive health;social;social health determinants;symposium;synergism;Training Programs;Underrepresented Minority;Universities;University resources;uptake;Vision;Work;working group

PROJECT_TITLE: The Hopkins Population Center


PI_NAMEs: AGREE, EMILY M (contact)

PROJECT_TERMS: Address;Agreement;Back;career;career development;Collaborations;Communities;community center;design;Development;Discipline;Educational workshop;Ensure;Evaluation;Faculty;Goals;Grant;Growth;Home;Infrastructure;innovation;Institution;Investments;Leadership;Libraries;member;Mission;Monitor;National Institute of Child Health and Human Development;outreach;Population;Population Dynamics;Population Research;Postdoctoral Fellow;R24;Reporting;Research;research and development;Research Personnel;response;Schools;Scientist;service delivery;Services;Specialist;success;Supervision;Time;training opportunity;Universities;Work


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: LA JOLLA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Acute myeloid leukemia is a major form of the blood cancer with very few targeted therapies. Over 50% of patients, who responded to initial chemotherapies, relapsed within five years and die from this disease. The aim of this application is to provide molecular insights into acute myeloid leukemia for better development of novel and effective treatments.

PI_NAMEs: ZHANG, DONG-ER  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Affect;AML1-ETO fusion protein;C-terminal;CD34 gene;Cell Death;Cell Death Induction;Cell Survival;Cells;chemotherapy;Chimeric Proteins;Chromatin;chromatin remodeling;Chromosomal translocation;Data;Defect;Development;Disease;dosage;Down-Regulation;driver mutation;effective therapy;Elements;Enzymes;epigenome;Event;Funding;Gene Expression Alteration;Germ Lines;Glutathione;Glutathione Metabolism Pathway;Goals;Guanosine Triphosphate Phosphohydrolases;Hematologic Neoplasms;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Human;human disease;Human Pathology;Immunodeficient Mouse;In Vitro;inhibitor;insight;Knowledge;Length;leukemia;Leukemic Cell;leukemic stem cell;leukemogenesis;Maintenance;Malignant Neoplasms;Mediating;Molecular;Molecular Abnormality;molecular pathology;mouse model;Mus;Mutation;NADPH Oxidase;new therapeutic target;novel;overexpression;Oxidative Phosphorylation;Oxidative Stress;Pathogenicity;Pathologic;Pathology;Patients;Penetrance;Physiological;Predisposition;Prognosis;Protein Isoforms;Reactive Oxygen Species;Relapse;retroviral transduction;Superoxides;t(8;21) acute myeloid leukemia;t(8;21)(q22;q22);targeted treatment;Testing;Therapeutic;therapeutic target;transcription factor;transcriptome;Transgenic Mice;transmission process;Work

PROJECT_TITLE: Molecular Mechanism of Leukemogenesis involving AML1-ETO

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Aging;Aphasia;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke;Telehealth

PHR: Project 1 - Narrative Although multiple sources suggest aphasia therapy is effective for improving language processing and quality of life, most persons with aphasia receive less therapy than what is optimal. The purpose of Project 1 is to improve access to aphasia therapy by demonstrating that telerehab is non-inferior to in-clinic aphasia therapy.

PROJECT_TERMS: Acute;Adopted;Affect;Ambulatory Care Facilities;Aphasia;aphasia recovery;Attitude;Biography;brain health;Caring;Case Study;Chronic;chronic stroke;Clinic;Clinical Trials;Cognitive;Communication;comparative efficacy;computerized;cost;Data;Databases;disability;Effectiveness;Enzyme-Linked Immunosorbent Assay;executive function;Future;Goals;Health;Home;Improve Access;improved;Individual;Inferior;Internet;Language;language processing;Language Therapy;Linguistics;Logistics;Medical;Meta-Analysis;Modality;Modeling;Motivation;Names;Neuropsychology;North America;Outcome;Outcome Measure;Participant;Pathologist;Patients;Personal Computers;personalized predictions;Persons;Phase;phase III trial;Philadelphia;phonology;Physical therapy;Policies;Population;pre-clinical;predicting response;primary endpoint;Probability;Production;Provider;Quality of life;Randomized;Recovery;rehabilitation service;Rehabilitation therapy;remote therapy;Research;rural area;Semantics;Services;Severities;Source;Speech;Speech Therapy;Stroke;stroke recovery;stroke-induced aphasia;stroke-like outcome;synergism;Technology;technology validation;Telemedicine;telerehabilitation;Testing;therapy outcome;Third-Party Payer;Transportation;Underserved Population;United States;Work

PROJECT_TITLE: Telerehab for Aphasia (TERRA)


NIH_SPENDING_CATS: Atherosclerosis;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: PROJECT NARRATIVE  Caribbean Hispanics are a population with a disproportionately high prevalence of cardio-metabolic disorders but with a limited expectation of benefits from current pharmacogenetic studies conducted mainly in subjects of mostly European ancestry. We focus on gene-drug interactions (GDDIs) to estimate the modifying effect of cilostazol on the weighted genetic risk score (wGRS)-driven prediction model for clopidogrel responsiveness and hence develop urgently-needed pharmacogenomic-driven prescription guidelines for this population while also using a semi-mechanistic population-based PK-PD analysis of such GDDI. Our project combines machine learning techniques (i.e., artificial intelligence), a pharmacokinetics and pharmacodynamics modeling approach, active metabolites measurements and genotyping with the development of more accurate rules for better predictability of GDDIs between clopidogrel and cilostazol in cardiovascular patients from this medically underserved population.

PI_NAMEs: DUCONGE, JORGE  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: absorption;acute coronary syndrome;Address;Adenosine Diphosphate;Adverse drug event;Adverse Drug Experience Report;Adverse effects;Affect;Age;Area;Artificial Intelligence;Biochemical;Biological Availability;Blood Platelets;Body mass index;Cardiometabolic Disease;Cardiovascular system;Caribbean Hispanic;Characteristics;Cilostazol;Clinical;clinical practice;Clinical Research;clinically actionable;clinically relevant;clinically significant;clopidogrel;Collagen;Coronary Arteriosclerosis;Coronary Artery Bypass;Costs and Benefits;CYP2C19 gene;CYP3A5 gene;Data;Demographic Factors;Development;Diabetes Mellitus;Disparity;Dose;Drug Combinations;Drug Exposure;Drug Interactions;Drug Kinetics;drug response prediction;Effectiveness;Elderly;Environment;Environmental Risk Factor;Ethnic Population;European ancestry;Exclusion;expectation;Exposure to;Family history of;Food;frontier;Gender;Genes;Genetic;Genetic Load;Genetic Polymorphism;Genetic Risk;genetic variant;Genome;genome wide association study;Genotype;Guidelines;Guns;health care service;health inequalities;Healthcare;Hematocrit procedure;Heritability;Heterogeneity;high body mass index;High Prevalence;Hispanic Populations;hypercholesterolemia;Individual;individualized medicine;Inflammation;inhibitor;insight;inter-individual variation;International;Kidney Failure;Knowledge;knowledgebase;Left Ventricular Ejection Fraction;Length;Lesion;Link;Machine Learning;machine learning method;Measurement;Measures;Medical;Medical center;medically underserved population;Metabolic;metabolic phenotype;Minority Groups;Modeling;Multivariate Analysis;Myocardial Infarction;non-genetic;novel;Obesity;Outcome;Pathway interactions;Patients;percutaneous coronary intervention;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;Pharmacogenetics;Pharmacogenomics;pharmacokinetics and pharmacodynamics;pharmacometrics;Pharmacotherapy;Phenotype;Play;Population;population based;precision medicine;Precision Medicine Initiative;predictive modeling;predictive tools;Procedures;Publishing;Purinoceptor;Recommendation;Regimen;Research;response;risk variant;Severities;Smoking;Solid;sound;Stents;success;System;systematic review;Techniques;Testing;Time;Translating;treatment response;Underrepresented Populations;United States National Institutes of Health;Up-Regulation;Variant

PROJECT_TITLE: Merging artificial intelligence (AI) and pharmacometrics to elucidate gene-drug interactions linked to clopidogrel responsiveness in Caribbean Hispanic patients


NIH_SPENDING_CATS: Biotechnology;Cancer;Chronic Pain;Dental, Oral, and Craniofacial Disease;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Radiation Oncology;Rare Diseases;Substance Misuse

ORG_CITY: RALEIGH

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: More than 80% of patients undergoing treatment for head and neck cancer are prescribed opioid pain killers for management of radiation-associated pain, and unfortunately, 6 months after finishing radiotherapy, one-third of head and neck cancer patients will still be opioid-dependent. Chronic opioid use is associated with side effects such as constipation and decreased alertness; it can also lead to opioid abuse, misuse, addiction, and eventual overdose. Safer, more effective and less addictive pain relief strategies are desperately needed, and our proposed research addresses that need by investigating a novel radiation-activated pain signaling pathway that might serve as an excellent target that could be inhibited with new pain medications.

PI_NAMEs: NOLAN, MICHAEL WARREN (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Ablation;Action Potentials;Acute;addiction;Address;Adult;Afferent Neurons;alertness;American;Analgesics;Anatomy;Animals;antagonist;Binding;Brain;Cancer Survivor;Caring;Cell Culture Techniques;Cells;Chemotherapy and/or radiation;Chronic;Constipation;Data;Development;Diagnosis;Epithelium;Evaluation;Exhibits;experience;experimental study;Face;Family;Family member;Generations;glial cell-line derived neurotrophic factor;Glossitis;Goals;Grant;Head and Neck Cancer;head and neck cancer patient;healing;Human;improved;In Vitro;in vivo;Inflammation;injured;innovation;Ion Channel;irradiation;keratinocyte;Knockout Mice;Knowledge;Label;Lead;malignant mouth neoplasm;Malignant Neoplasms;Measures;Mediating;Methods;Molecular;mouse model;Mus;NCAM1 gene;Nerve;Nerve Endings;neural circuit;Neurons;neutralizing antibody;new therapeutic target;non-opioid analgesic;novel;novel therapeutics;Operative Surgical Procedures;Opiate Addiction;Opioid;opioid abuse;opioid therapy;opioid use;Oral;Oral cavity;oral mucositis;Oral mucous membrane structure;orofacial;Oropharyngeal;Overdose;overexpression;Pain;pain behavior;Pain management;pain relief;pain sensation;pain signal;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;prescription opioid;prevent;Production;Quality of life;Radiation;Radiation therapy;receptor;recruit;Reporting;Research;response;Risk;Role;Sampling;side effect;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Somatosensory Cortex;Spinal Cord;Stimulus;Testing;Therapeutic;Tissues;Tongue;Transgenic Organisms;Trigeminal nerve structure;Trigeminal System;Up-Regulation;Vascular Smooth Muscle;Work

PROJECT_TITLE: Evaluation of TRPM8-expressing neurons as novel regulators of acute radiotherapy-associated pain in patients with head and neck cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GEMMILL, ALISON  (contact)

PROJECT_TERMS: Acceleration;Agreement;Area;Back;Biosensor;career;Communities;Complement;Cost Sharing;COVID-19;Data;data hub;Demography;Development;Educational workshop;effectiveness evaluation;Endowment;Engineering;Event;Faculty;Family;Family Planning;Feedback;Fertilization;Financial Support;Funding;Goals;Grant;Growth;Health;Health Planning;Incubated;Inequality;Infrastructure;innovation;instrument;Interdisciplinary Study;interest;Investments;Lightning;Maternal and Child Health;member;Mentors;Mentorship;multidisciplinary;multiple omics;next generation;pilot test;Population;Population Dynamics;Positioning Attribute;Postdoctoral Fellow;Poverty;Poverty Areas;Productivity;Professional Organizations;Program Efficiency;programs;Recording of previous events;repository;Reproductive Health;Research;Research Activity;research and development;Resources;Scientist;Series;Services;sexual and reproductive health;social factors;Strategic Planning;Structure;success;symposium;United States National Institutes of Health;Universities;working group;Writing

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Rehabilitation;Serious Mental Illness;Telehealth

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Although cognitive-behavioral therapy (CBT) has shown efficacy in reducing symptoms and rates of mood relapse in adolescents at high risk for severe mood disorders (SMD; i.e., bipolar I/II disorder and recurrent or unremitting major depression), a significant limitation to the CBT’s efficacy is the low rate of participant adherence to the prescribed between-session homework tasks. Mobile health applications have the potential to improve adherence to and acceptance of treatment through embedded treatment content, skill-practice, thought and symptom monitoring, all of which are facilitated by reward contingencies and notifications. This study will examine whether a mobile application-enhanced CBT can improve participant adherence and treatment acceptance for adolescents at high risk for SMD.

PI_NAMEs: WEINTRAUB, MARC JOSHUA (contact)

PROJECT_TERMS: Adherence;adherence rate;Adolescence;Adolescent;Affect;affective disturbance;Age;Anxiety Disorders;behavioral response;Bipolar I;career;Clinical;Clinical Trials;Cognitive;cognitive enhancement;cognitive reappraisal;Cognitive Therapy;Conduct Clinical Trials;Data;Data Analyses;design;Development;Diagnostic;Disease;Doctor of Philosophy;Educational process of instructing;Effectiveness;efficacy study;efficacy testing;Environment;Evaluation;evidence base;experience;Family;Feedback;Focus Groups;Fostering;functional improvement;functional outcomes;Funding;Goals;Health Technology;high dimensionality;high risk;improved;Individual;Institution;Interview;K-Series Research Career Programs;Link;Major Depressive Disorder;Mediating;Mediator;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Methods;mHealth;mobile application;Mobile Health Application;Modification;Monitor;Mood Disorders;Moods;Motivation;National Institute of Mental Health;Notification;Outcome;Parents;Participant;Patient Compliance;patient engagement;Population;Positioning Attribute;Postdoctoral Fellow;Protocols documentation;psychiatric symptom;psychosocial;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recurrence;reduce symptoms;Relapse;Reporting;Research;Research Personnel;Resources;Rewards;Risk;satisfaction;skills;stressor;sugar;symptomatic improvement;Symptoms;Technology;Testing;Therapeutic;Thinking;Training;treatment adherence;treatment effect;Treatment Efficacy;treatment group;Treatment outcome;usability;user-friendly;Validation;Youth

PROJECT_TITLE: App-Enhanced CBT for Adolescents at High Risk for Severe Mood Disorders


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Hepatitis - C;Infectious Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE. HCV and HBV represent the leading cause for hepatocellular carcinoma (HCC). The risk of HCC remains even after virus elimination. Thus, it is of the utmost importance to identify novel therapeutic approaches to treat viral hepatitis infection and viral hepatitis-induced HCC.

PI_NAMEs: GALLAY, PHILIPPE ANDRE (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: analog;Anti-viral Agents;anticancer activity;Awareness;BAY 54-9085;Biological Markers;Cancer Etiology;cell growth;Cessation of life;chemotherapy;co-infection;Complex;Congresses;Cyclophilin A;Cyclophilins;Cyclosporine;cytokine;Cytostatics;Derivation procedure;Development;Dose;experimental study;Funding;Growth;HBV HCC;Hepatic;Hepatitis B Infection;Hepatitis B Virus;Hepatitis C;Hepatitis C Therapy;Hepatitis C virus;Hepatocyte;hepatoma cell;high risk;Human;Implant;improved;In Vitro;in vivo;Incidence;Infection;Infection prevention;inflammatory modulation;inhibitor;Link;liver injury;Malignant neoplasm of liver;Mediating;Membrane;Molecular;mortality;mouse model;Mus;Nocodazole;novel;novel drug combination;novel strategies;novel therapeutic intervention;novel therapeutics;Patients;Pharmaceutical Preparations;prevent;Primary carcinoma of the liver cells;Property;Public Health;Recurrence;Regimen;Reporting;Research;Resistance;Risk;RNA replication;sanglifehrin A;targeted treatment;Therapeutic;Therapeutic Agents;tool;TP53 gene;treatment duration;Vesicle;Viral;Viral Cancer;Viral hepatitis;Viral Physiology;viral RNA;Virus;Virus Replication

PROJECT_TITLE: Non-immunosuppressive Sanglifehrin Analogs as Therapeutic Agents for Viral Hepatitis-induced Liver Damage Development

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Asthma;Cancer;Clinical Research;Lung

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative This proposal focuses on the role of prostaglandin E2, a naturally produced substance, in preventing severe inflammation in asthma. Completion of the studies will reveal potential new therapeutic strategies for asthma, sinus disease and other common disorders.

PI_NAMEs: BOYCE, JOSHUA A (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: airway inflammation;Anti-Inflammatory Agents;aspirin-exacerbated respiratory disease;Asthma;Atlases;Atopic Dermatitis;Attenuated;Basal Cell;Binding;Biological Availability;Cell Nucleus;Cell surface;Cell Surface Receptors;Chronic;chronic rhinosinusitis;Clinical;cytokine;Cytoprotection;Development;Dinoprostone;Disease;DNA-Binding Proteins;Endothelial Cells;Epithelial Cells;Epithelium;Equilibrium;expectation;extracellular;Food Hypersensitivity;Functional disorder;Homologous Gene;House Dust Mite Allergens;human subject;Immunity;immunopathology;Impairment;in vivo;Inflammation;Innate Immune Response;Interleukin-1 Receptors;Interleukin-13;Interleukin-5;Interleukins;Length;lipid mediator;Lung;Lymphoid Cell;mast cell;Mediating;Membrane;Molecular;Mus;Nose;novel;novel therapeutic intervention;oxidation;Pathologic;Pathway interactions;Patients;Peptide Hydrolases;polyposis;prevent;Process;Production;Proteins;receptor;receptor binding;Regulation;repaired;respiratory;Respiratory System;response;Role;Serum;Signal Transduction;single-cell RNA sequencing;Sinus;Sinusitis;Site;Sorting;Stress;Syndrome;Testing;Therapeutic;therapeutic target;Tissues;Transcript;Transgenic Mice;Tumorigenicity;Up-Regulation

PROJECT_TITLE: Prostaglandin E2-Dependent Control of a Mast Cell IL-33/ST2 Pathway in Asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(57)]


NIH_SPENDING_CATS: Aging;Aphasia;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Genetics;Mental Health;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

PHR: This research will contribute to determining if taking daily escitalopram (a medication that is approved by the FDA for treatment of depression and anxiety) boosts language therapy in helping people recover from language impairment (aphasia) after stroke, independently of its effects on depression. Aphasia has an important impact on the interpersonal relationships of stroke survivors and their re-entry into work and social settings. This research will lay the groundwork for designing a Phase III clinical trial language therapy plus escitalopram (compared to placebo) for aphasia early after stroke.

PI_NAMEs: HILLIS, ARGYE E. (contact)

PROJECT_TERMS: Affect;Aftercare;Alleles;Amphetamines;Anodes;Anxiety;Aphasia;aphasia recovery;Brain;Brain-Derived Neurotrophic Factor;Clinical Trials;cognitive recovery;Communication;Computers;Data;design;Dextroamphetamine;disability;Dopamine;Double-Blind Method;double-blind placebo controlled trial;Education;Effectiveness;Electronic Mail;Escitalopram;FDA approved;Fluoxetine;Functional Magnetic Resonance Imaging;Genes;Genetic Carriers;Genetic Polymorphism;genetic testing;Genotype;Goals;Hospitals;Hour;improved;Individual;Infarction;Insurance;Interpersonal Relations;Intervention;Language;language impairment;Language Therapy;Left;Lesion;Literature;Magnetic Resonance Imaging;Measures;Mediating;Medical;meetings;Mental Depression;Motor;motor recovery;Names;neuromechanism;Outcome;Participant;Persons;Pharmaceutical Preparations;Phase;Phase III Clinical Trials;Placebos;post stroke;Production;Provider;Quality of life;Randomized;randomized placebo-controlled clinical trial;Randomized, Controlled Trials;Recovery;Recovery Support;Rehabilitation therapy;Research;Research Personnel;Residual state;response;Rest;Risk;secondary outcome;Selective Serotonin Reuptake Inhibitor;Severities;side effect;Single Nucleotide Polymorphism;social;Social Interaction;Speech;Stroke;stroke survivor;stroke-induced aphasia;Structure;Superior temporal gyrus;Survivors;Telephone;Testing;transcranial direct current stimulation;Transcranial magnetic stimulation;treatment response;United States;White Matter Disease;Work

PROJECT_TITLE: Escitalopram and Language Intervention for Subacute Aphasia (ELISA)


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: HAO, LINGXIN  (contact)

PROJECT_TERMS: Address;Adoption;African;Age;Area;Bayesian Modeling;Biological Markers;Biometry;career;Cohort Studies;Computers;Consultations;Country;COVID-19 pandemic;Data;data acquisition;Data Analyses;Data Analytics;Data Collection;data management;Data Science;Data Sources;design;Development;digital;econometrics;Educational workshop;Event;Fertilization;Funding;Goals;Growth;Health Sciences;High Performance Computing;improved;Influentials;informal learning;innovation;laptop;Lead;Licensing;Link;Mathematics;Measurement;Memory;Methodology;Methods;Modeling;Output;Population;Population Dynamics;Population Process;Population Sciences;Postdoctoral Fellow;Production;Productivity;Program Development;programs;Public Health;Publications;Research;Resources;Series;Services;simulation;social;sociodemographics;South Asian;Survey Methodology;Surveys;synergism;Techniques;Time;Universities;wearable data;Work

PROJECT_TITLE: Scientific Core


PHR: PROJECT NARRATIVE The long-term goal of this work is to help people with peripheral artery disease presenting with intermittent claudication to regain their lost lower extremity function. This project will develop a bioengineered translational composite matrix with injectable, in situ forming, angiogenic, antioxidative, resilient characteristics to improve hemodynamic, histologic, and functional endpoints of the ischemic hindlimb in a rat and a porcine model of peripheral artery disease.

PI_NAMEs: LI, XIAOWEI  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Address;Affect;angiogenesis;Angiogenic Factor;Animal Model;Antioxidants;Arteries;Biochemical;Biocompatible Materials;Biological Assay;biomaterial compatibility;Biomedical Engineering;Blood capillaries;Blood flow;blood perfusion;Cell Therapy;Cells;Characteristics;claudication;Clinical Trials;clinically relevant;controlled release;Defect;design;Development;Disease;Endothelial Cells;Environment;Excision;Fiber;Functional disorder;gene therapy;Goals;Growth Factor;Guanine Nucleotide Exchange Factors;hemodynamics;Hindlimb;Histologic;Histology;Human;Hydrogels;Image;Immunohistochemistry;improved;In Situ;In Vitro;Infection;Inflammation;Injectable;innovation;interfacial;Intermittent Claudication;Intramuscular;Ischemia;Lasers;Leg;Ligation;Limb structure;Lipids;Local Therapy;Lower Extremity;mechanical properties;Mechanics;Mediating;minimally invasive;Modeling;Muscle;Muscle Contraction;Muscle Fibers;Myocardium;Myopathy;nanofiber;Natural regeneration;novel;novel therapeutics;Oryctolagus cuniculus;oxidation;oxidative damage;Pathology;Patients;Performance;Perfusion;Peripheral arterial disease;Persons;Physiological;porcine model;Porosity;prevent;Property;Rattus;Reactive Oxygen Species;Recovery;Recovery of Function;recruit;Reperfusion Therapy;Reporting;Repression;resilience;Running;skeletal;Skeletal Muscle;soft tissue;stem cells;Stromal Cell-Derived Factor 1;Swelling;System;Testing;therapy development;Tissues;tool;Trauma;treadmill;Vascular Endothelial Growth Factors;Vascularization;Work

PROJECT_TITLE: Bioengineered Composite for the Treatment of Peripheral Arterial Disease

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_DEPT: OTOLARYNGOLOGY

PHR: High-risk human papillomavirus infections cause cervical cancer and other genital and oropharyngeal cancers that account for nearly 5% of cancers worldwide. HPV-positive cancers are poorly differentiated and restoring differentiation in a cancer caused by HPV infection has high therapeutic potential. The goal of this proposal is to understand how the high-risk HPV E7 oncoprotein inhibits epithelial differentiation.

PI_NAMEs: WHITE, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 3-Dimensional;Anogenital cancer;Anti-viral Agents;Automobile Driving;Binding;Biological Assay;Biology;Cancer Burden;Cancer Etiology;carcinogenicity;Cell Differentiation process;Cell Line;Cell Reprogramming;Cellular biology;Collection;Cyclin-Dependent Kinase Inhibitor;Data;defined contribution;Environment;Epithelial Cells;Epithelium;experimental study;Gene Expression;Genetic Complementation Test;genetic regulatory protein;Genetic Transcription;Genitalia;Goals;high risk;Homeostasis;HPV E7;HPV positive;HPV-High Risk;Human;human model;Human papilloma virus infection;Human Papillomavirus;Impairment;Inhibition of Apoptosis;keratinocyte;keratinocyte differentiation;Knock-out;Lesion;Link;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Mediating;Modeling;multicatalytic endopeptidase complex;Mutation Analysis;notch protein;novel therapeutic intervention;Oncogenic;Oncoproteins;Papillomavirus Transforming Protein E6;premalignant;Proliferating;protein complex;Protein Family;Protein Tyrosine Phosphatase;Proteins;Reagent;Regulation;Repression;Research Personnel;Retinoblastoma;retinoblastoma tumor suppressor;Role;S phase;Signal Transduction;Stratified Epithelium;Stratified Squamous Epithelium;Testing;Therapeutic;Time;tool;Tropism;Tumor Suppressor Proteins;two-dimensional;Update;Variant;Viral Genome;Virus;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Human Papillomavirus Manipulation of Epithelial Differentiation

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


PI_NAMEs: BONILHA, LEONARDO F (contact)

PROJECT_TERMS: Acute;acute symptom;Address;Affect;Aging;Anatomy;Aphasia;aphasia recovery;base;Behavioral;Blood Vessels;Brain;brain control;brain health;Brain Injuries;brain magnetic resonance imaging;Brain region;brain tissue;cardiovascular health;cardiovascular risk factor;Characteristics;Chronic;Clinical;Cognitive;cognitive reserve;Collaborations;Compensation;connectome;Data;Diffusion Magnetic Resonance Imaging;Exhibits;experience;Fiber;Goals;Guidelines;Hemorrhage;Human;Image;Impairment;Individual;Injury;innovation;International;Ischemia;Language;Language Disorders;language impairment;Lead;Lesion;lexical;Linguistics;Literature;Location;loss of function;Maps;Measures;Mediating;Mediation;Medical;Metabolic;Methods;Microvascular Dysfunction;Modeling;multimodal learning;multimodal neuroimaging;multimodality;Nervous System Trauma;network architecture;neural network architecture;Neurobiology;neuroimaging;Neurologic;Neurons;novel;older adult;Outcome;Pathway interactions;persistent symptom;Phonetics;phonology;post stroke;Predisposition;preservation;Recovery;Reporting;Research;Residual state;resilience;Semantics;Severities;Shapes;Stroke;stroke recovery;stroke survivor;stroke-induced aphasia;Symptoms;synergism;Testing;Tissues;Vascular blood supply;white matter;Work

PROJECT_TITLE: Brain Health and Aphasia Recovery


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The NYNORC, the oldest NIH obesity research center, operates in support of $60M per year of peer-reviewed obesity-related research. Through closely integrated, outstanding core facilities, pilot projects, enrichment and clinical activities, the center has made major contributions to basic understanding and applied approaches to the problem of obesity. Our goal remains to expand the knowledge base relating to the causes, complications and treatments of obesity.

PI_NAMEs: FERRANTE, ANTHONY W;GALLAGHER, DYMPNA  (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Achievement;Address;Advisory Committees;Ally;Animals;Area;Award;Back;base;Basic Science;Behavior;Behavioral;Bile Acids;Biology;Biomedical Research;Body Composition;Cell Therapy;Center Core Grants;Clinical;clinical care;Clinical Investigator;Collaborations;college;Communities;comorbidity;Core Facility;COVID-19 pandemic;Creativeness;Defense Mechanisms;design;Development;Diabetes Mellitus;Direct Costs;Disease;dosage;Eating;Elements;Environment;Etiology;Evolution;Fatty Liver;Food Intake Regulation;Fostering;Foundations;frontier;Functional disorder;Funding;Funding Agency;Genes;Goals;Grant;Human;Individual;innovation;insight;Institution;instrument;interdisciplinary collaboration;Interdisciplinary Study;interest;Investigation;investigator training;knowledge base;Laboratories;Manuscripts;Mediation;Medical center;Medicine;member;Mentors;Metabolic;Molecular Biology;Molecular Genetics;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Neurobiology;Neurons;Neurosciences;New York;Newborn Infant;next generation;novel;Nutrient;nutrition;Nutritional;Nutritional Study;Obesity;obesity development;obesity in children;obesity treatment;Pathogenesis;Pathology;Patients;Peer Review;Pharmacologic Substance;Phenotype;Physiological;Physiology;Pilot Projects;practical application;preference;Prevention;Prevention approach;Prevention strategy;Productivity;programs;Publishing;Recording of previous events;Regulation;Research;research clinical testing;Research Personnel;Research Project Grants;Resources;risk variant;Role;Science;Scientist;Series;Services;skills;Specialized Center;stem cells;sugar;Techniques;tool;Training;Translational Research;translational research program;treatment strategy;United States National Institutes of Health;Universities;Weight;Weight Gain

PROJECT_TITLE: New York Obesity Research Center


NIH_SPENDING_CATS: Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: LEIBEL, RUDOLPH L (contact)

PROJECT_TERMS: Accounting;Address;Advocate;Animals;Clinical;Clinical Research;Collaborations;Communities;Consultations;cost effective;Ensure;Equity;Evaluation;Faculty;Financial Support;Foundations;Funding;Goals;Grant;Human;IACUC;Individual;Industry;Infrastructure;Institution;Institutional Review Boards;Investments;Laboratory Finding;Manuscripts;Mediation;member;Mentors;Mission;Molecular Biology;Molecular Genetics;Neurosciences;New York;nutrition;Obesity;operation;Parents;Persons;Phenotype;Postdoctoral Fellow;Productivity;programs;Protocols documentation;Publishing;Research;Research Design;Research Institute;Research Personnel;Resources;Role;Running;Scientist;Secure;Self-Examination;Services;Suggestion;Testing;translational potential;Translational Research;translational research program;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: Los Angeles

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Myocardial infarction is one of the most common cardiac injuries worldwide and routinely leads to heart failure. In a myocardial infarction, part of the heart is deprived of oxygen, but the mechanisms of how oxygen deprivation causes changes in cardiac function are poorly understood. The goal of this project is to engineer innovative cell culture devices to determine how oxygen deprivation changes the function of cells in the heart, which can lead to new therapeutic strategies for mitigating the effects of a myocardial infarction.

PI_NAMEs: MCCAIN, MEGAN LAURA (contact)

PROJECT_TERMS: Affect;Area;Arrhythmia;Beds;Biological Assay;Blood;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cell Communication;Cell Culture Techniques;Cell Hypoxia;Cell Physiology;cell type;Cells;Characteristics;chromatin immunoprecipitation;Communication;Complex;coronary artery occlusion;Data;deprivation;Devices;Distal;Distant;Engineering;Environment;exosome;Fibroblasts;Fibrosis;Gases;Gene Expression;Goals;Heart;Heart failure;heart function;Heart Injuries;Human;human induced pluripotent stem cells;Hypertrophy;Hypoxia;hypoxia inducible factor 1;In Vitro;in vitro Model;in vivo Model;Incubators;Individual;Infarction;Injury;innovation;insight;Investigation;Measures;Mediating;Microfluidics;microphysiology system;MicroRNAs;Modeling;Molecular;molecular phenotype;Muscle;Muscle Cells;myocardial hypoxia;Myocardial Infarction;Myocardium;Myofibroblast;Necrosis;novel therapeutic intervention;novel therapeutics;Nuclear;Oxygen;Paracrine Communication;Pathologic;Pathway interactions;Phenotype;post intervention;prevent;Process;Proteins;Rattus;response;RNA;Role;screening;severe injury;Signal Transduction;Site;Stress;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;transcription factor;Ventricular Remodeling

PROJECT_TITLE: Engineering a Microphysiological System to Model the Infarct Border Zone and Interrogate Oxygen-Dependent Cell-Cell Communication in the Myocardium

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]