NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

PI_NAMEs: BRODY, ABRAHAM AIZER (contact)

PROJECT_TERMS: Address;adverse outcome;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Antipsychotic Agents;Assessment tool;Award;Biological;career;Caregiver Burden;Caregivers;caregiving;Caring;Collaborations;collaboratory;community based service;community setting;Complex;Data;data infrastructure;Dementia;dementia care;design;Development;Diagnosis;Discipline of Nursing;Doctor of Philosophy;efficacy trial;Ensure;Environment;Ethics;Ethnic Origin;evidence base;Evidence based practice;experience;falls;Fostering;Funding;Future;Goals;Growth;Guidelines;Health;Healthcare;Healthcare Systems;home based service;Hospitals;improved;Income;Individual;Infection;Infrastructure;Intervention;Investments;Life Cycle Stages;Measurement;Medicine;Mentorship;Methodology;mid-career faculty;Monitor;National Institute on Aging;Nature;New York;Nonpharmacologic Therapy;Nurses;Nursing Homes;Outcome;patient home care;Patients;Persons;Phase;Pilot Projects;pilot test;Policies;Population;Pragmatic clinical trial;pragmatic trial;Process;Quality of life;racial minority;Research;Research Personnel;Resources;restraint;Risk;sedative;sex variable;skills;Structure;success;symposium;systems research;Testing;Time;Training;training opportunity;United States National Institutes of Health;Universities;Vulnerable Populations;Well in self;Woman;Work;working group

PROJECT_TITLE: Pilot Studies Core


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Patient Safety

ORG_CITY: PROVIDENCE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PI_NAMEs: HANSON, LAURA C (contact)

PROGRAM_OFFICER_NAME: BHATTACHARYYA, PARTHA

PROJECT_TERMS: Acceleration;administrative database;Advance Care Planning;Adverse event;adverse outcome;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;American;care fragmentation;career development;caregiver strain;Caregivers;Caring;Clinical;clinical outcome assessment;Clinical Trials;clinically significant;Cognition;Collaborations;collaboratory;Common Data Element;Complex;Conceptual Domain;Consultations;cost;cost of dementia;Data;Data Collection;Dementia;dementia care;design;Development;Diagnosis;Distress;diversity and inclusion;Electronic Health Record;Emotional;Employment;Ethics;Evidence based intervention;experience;Family;Family Caregiver;feeding;Functional dependence;Funding;Geriatrics;Goals;Health;health disparity;Healthcare;Healthcare Systems;improved;instrument;large datasets;Libraries;Lived experience;Measurement;Measures;member;Mental Depression;Methodology;Methods;Modeling;National Institute on Aging;neuropsychiatric symptom;Nursing Homes;Outcome;Outcome Measure;Pain;Patient Outcomes Assessments;Patients;Performance;Persons;physical symptom;Pilot Projects;Pragmatic clinical trial;pragmatic trial;Prevalence;Process;Protocols documentation;Proxy;Quality of life;Registries;Regulation;Reporting;Research;Research Design;Research Personnel;Resources;Respondent;satisfaction;Science;Services;Shortness of Breath;Specific qualifier value;Staging;symposium;Symptoms;System;systematic review;systems research;Technology;Training;Translations;Uninsured Medical Expense;United States National Institutes of Health;Work

PROJECT_TITLE: Patient & Caregiver Reported Outcomes (PCRO) Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Comparative Effectiveness Research;Dementia;Dissemination and Implementation Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care

PI_NAMEs: GITLIN, LAURA N. (contact)

PROJECT_TERMS: Address;Adoption;Adult;Alzheimer's Disease;Alzheimer's disease related dementia;Attention;Behavioral Symptoms;career development;Caregiver well-being;Caregivers;Caring;Categories;Characteristics;Clinical;clinically relevant;collaboratory;Committee Members;Communication;Communities;community based service;Complex;Conceptions;contextual factors;daily functioning;Dementia;dementia care;design;Development;diagnostic tool;Dissemination and Implementation;diversity and inclusion;Ethics;evidence base;experience;Failure;Family;Family Caregiver;Funding;health care settings;Health Personnel;Healthcare Systems;Hospitals;implementation barriers;implementation facilitators;implementation research;improved;inattention;International;Intervention;Knowledge;Leadership;Life Cycle Stages;Literature;Long-Term Care;Long-Term Care for Elderly;Managed Care;Methodology;Methods;Modeling;Monitor;Names;Nonpharmacologic Therapy;novel;Nursing Homes;Outcome;payment;Persons;Pilot Projects;pragmatic trial;Primary Care;Process Measure;programs;protocol development;Provider;Quality of life;Readiness;Regulation;Research;Research Personnel;Science;Services;Site;social media;Specific qualifier value;statistics;Structure;success;System;systems research;Testing;therapy development;tool;Training;trial design;United States National Institutes of Health;Update;web site

PROJECT_TITLE: Dissemination & Implementation Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

PI_NAMEs: LARSON, ERIC B (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Adopted;Adoption;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;Caregivers;Caring;case finding;clinical practice;Collaborations;collaboratory;Communities;Complex;Data;data exchange;Dementia;dementia burden;Dementia caregivers;design;Development;Diagnosis;Effectiveness of Interventions;efficacious intervention;Electronic Health Record;Emotional;Ensure;experience;feasibility testing;Financial Hardship;Fostering;Foundations;Funding;health care delivery;health care service organization;Health system;Healthcare;Healthcare Systems;Heterogeneity;Hospitals;improved;informal caregiver;insight;Institution;Integrated Delivery Systems;Intervention;K-Series Research Career Programs;Knowledge;knowledge base;Learning;Medical;medical complication;meetings;National Institute on Aging;Nonpharmacologic Therapy;novel;Nursing Homes;patient home care;Patients;Persons;Pilot Projects;Population;Pragmatic clinical trial;programs;Protocols documentation;Provider;Readiness;Research;Research Personnel;research study;Resources;Service delivery model;successful intervention;System;systems research;Testing;therapy design;United States National Institutes of Health;virtual;Work;World Health

PROJECT_TITLE: Health Systems Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences

PI_NAMEs: CALLAHAN, CHRISTOPHER M (contact)

PROJECT_TERMS: Academia;academic program;Address;Alexia;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;Award;Boston;care outcomes;career;Caregivers;Caring;Clinical and Translational Science Awards;Clinical Research;Collaborations;collaboratory;Complex;Dementia;Development;Doctor of Philosophy;doctoral student;Educational workshop;experience;Funding;Future;Government;Health Services Accessibility;Healthcare Systems;improved;improved outcome;Individual;Infrastructure;investigator training;Joints;K-Series Research Career Programs;Manuscripts;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;National Institute on Aging;next generation;Online Systems;Participant;patient oriented research;peer;Persons;Pilot Projects;Postdoctoral Fellow;Pragmatic clinical trial;pragmatic trial;Productivity;programs;recruit;Research;Research Personnel;Resources;safety net;Series;skills;Structure;systems research;Talents;Training;Training Activity;Training Programs;Training Support;Underrepresented Minority;United States National Institutes of Health;Woman;Work;working group;Writing

PROJECT_TITLE: Training Core


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE: Traumatic brain injury (TBI) is a significant problem for U.S. Hispanic children; rehabilitation after TBI decrease disability, but requires timely initiation, and long treatments in hospitals, community healthcare facilities and schools. While parents play a critical role in their child’s recovery, Hispanic parents face substantial barriers that can result in delayed initiation of treatments and higher disability. Our study evaluates the effect of a culturally and linguistically tailored TBI education and navigation intervention, aimed to improve parental caregiving self-efficacy, optimize access and adherence to rehabilitation and ultimately improve outcomes in an underserved and rapidly growing population.

PI_NAMEs: JIMENEZ, NATHALIA  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: acceptability and feasibility;Acculturation;Acquired disability;Active Learning;Acute;Address;Adherence;Adolescent;Affect;Ambulatory Care;Anxiety;Appointment;Area;attentional control;bilingualism;Brain Injuries;care providers;caregiving;Caring;Cellular Phone;Central America;Child;Child Care;Childhood Injury;Cognitive;Communication;Communities;Community Healthcare;community organizations;comparison control;Control Groups;craniofacial;Data;Devices;disability;Education;education planning;education resources;Educational Status;Effectiveness;efficacy testing;Emotional;emotional functioning;Enrollment;Exclusion;Face;Family;flexibility;follow-up;functional gain;functional outcomes;functional status;Future;group intervention;Health care facility;health literacy;health related quality of life;Health Services;Healthcare;high risk population;Hispanic;Hispanic Populations;Hospitalization;Hospitals;Immigrant;Improve Access;improved;improved outcome;Income;Individual;Injury;Inpatients;Institution;Intervention;intervention effect;Knowledge;Linguistics;literacy;long-term rehabilitation;Measures;Mediator;Medicaid;Mental Depression;Mental Health;Mexico;Minority Groups;Modeling;neurosurgery;Not Hispanic or Latino;novel;Outcome;Outpatients;outreach;Pamphlets;Parents;Participant;Performance;Persons;Physical Function;pilot test;Play;Population;Population Growth;Populations at Risk;post intervention;primary caregiver;primary outcome;Problem Solving;programs;Proxy;Randomized;Randomized, Controlled Trials;Records;Recovery;Rehabilitation therapy;Reporting;Research;Risk;Risk Factors;Role;Schools;secondary outcome;Self Care;Self Efficacy;skills;social cognitive theory;social engagement;Spanish;TBI treatment;Testing;theories;therapy design;Time;Traumatic Brain Injury;treatment adherence;Uninsured;Work

PROJECT_TITLE: Brain Injury Outpatient Education and Care Navigation

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Neurodegenerative;Neurosciences;Opioids;Pain Research;Patient Safety;Peripheral Neuropathy;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PI_NAMEs: DOAN, LISA ;WANG, JING  (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Absence of pain sensation;Acetaminophen;Acute Pain;Agreement;Alabama;Anxiety;Arkansas;arm;Bolus Infusion;Breast-Conserving Surgery;Brief Pain Inventory;Chronic;chronic pain;Clinic;Clinical;Clinical and Translational Science Awards;cohort;Development;effectiveness research;effectiveness study;effectiveness trial;efficacy testing;Hospitals;Hour;Incidence;Infusion procedures;Ketamine;Lymph Node Dissections;Mastectomy;Memorial Sloan-Kettering Cancer Center;Mental Depression;Modeling;Moods;multimodality;Nature;Neuropathy;Non-Steroidal Anti-Inflammatory Agents;Operative Surgical Procedures;Opiate Addiction;opioid epidemic;opioid use;Pain;pain catastrophizing;Pain management;Pain Measurement;painful neuropathy;Patients;Perioperative;Physical Function;Placebos;Postoperative Pain;Postoperative Period;precision medicine;prevent;Prevention;primary endpoint;Randomized;Recommendation;Regimen;Risk;Saline;Severities;Site;success;Surgical incisions;Syndrome;treatment effect;United States National Institutes of Health;Universities;Washington;Woman

PROJECT_TITLE: Optimizing the use of ketamine to reduce chronic postsurgical pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NeuroTech Harbor (NTH) led by Johns Hopkins and Howard Universities will gather innovators, expert mentors, and resource providers to accelerate the development of highly promising solutions to improve neurological health for all. To address the lack of women and under-represented minority innovators, it will create the nation's first incubator ecosystem with an Equitech philosophy - the belief that diversity of teams, leadership, and perspectives is a force multiplier to fuel innovation producing solutions accessible to all communities.

PI_NAMEs: ETIENNE-CUMMINGS, RALPH ;MANAYE, KEBRETEN F;NWULIA, EVARISTUS A;SARMA, SRIDEVI V. (contact);THAKOR, NITISH VYOMESH;YAZDI, YOUSEPH

PROGRAM_OFFICER_NAME: WOLFSON, MICHAEL

PROJECT_TITLE: NeuroTech Harbor: Our nation's first equitech ecosystem for neuromedical technologies


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Risk for major depressive disorder (MDD) dramatically increases during adolescence, particularly for females, and although interpersonal stress generation is an established risk factor, it is essential to clarify the underlying mechanisms to improve early detection and prevention of depression risk. The current study will utilize a multi- wave prospective design to examine neural and real-world affective reactivity to negative social interactions as prospective predictors of interpersonal stress generation and subsequent increases in depression symptoms in female adolescents at elevated risk for depression. Ultimately, the elucidation of brain and behavioral mechanisms underlying interpersonal stress generation and subsequent depression risk in female adolescents may contribute to greater understanding of the etiology of adolescent depression and aid in identifying novel targets for intervention.

PI_NAMEs: FEURER, COPE  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affective;affective neuroscience;Age;Area;Behavior;behavior prediction;Behavioral;Behavioral Mechanisms;Biological;Brain;career;Chicago;child depression;Coupled;Cues;Data;depression prevention;depressive symptoms;design;Detection;Development;disorder risk;Down-Regulation;Early Diagnosis;Ecological momentary assessment;Enrollment;Environment;Etiology;Exhibits;Family;Female;Female Adolescents;follow-up;Functional Magnetic Resonance Imaging;Future;Generations;girls;Goals;Grain;Grant;Illinois;imaging study;improved;indexing;Individual;Intervention;Interview;Life Stress;Link;Major Depressive Disorder;Mediating;Mediator;Mental Depression;Mentorship;Methodology;Modeling;Moods;Morbidity - disease rate;multilevel analysis;National Institute of Mental Health;negative affect;neural;neural correlate;neural patterning;Neurobiology;neuroimaging;neuromechanism;novel;Nucleic Acid Regulatory Sequences;Onset of illness;Parents;Patient Self-Report;peer;Peripheral;Prevention;Process;prospective;Recording of previous events;Recurrence;Regulation;Reporting;Research;response;Risk;Risk Factors;Role;Sampling;Self Assessment;skill acquisition;skills;social;social exclusion;Social Interaction;Social Processes;social stress;Statistical Methods;Stress;Stressful Event;stressor;Suicide;Techniques;Testing;theories;Time;Training;translational scientist;Universities;Variant;Work;Youth

PROJECT_TITLE: Brain-Behavioral Predictors of Interpersonal Stress Generation and Depression Risk in Adolescent Girls

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Aging;Microbiome;Nutrition;Obesity

ORG_CITY: FARMINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Aging and age-related metabolic dysfunction poses unprecedented challenge to public health, and development of innovative and targetable interventions is highly warranted. Our project will examine the interplay of the microbiome and cellular senescence underlying diet-induced metabolic dysfunction in mice with older age. It will offer an integrative understanding of pathophysiology of age-related diseases, and lay a solid foundation to develop robust interventions targeting senescence, microbiome or both to improve health and increase longevity.

PI_NAMEs: XU, MING ;ZHOU, YANJIAO  (contact)

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TERMS: Adipocytes;Affect;age effect;age related;age related chronic disease;age-related disease;Aging;aging related;Agreement;anti aging;Anti-Inflammatory Agents;Attenuated;Bacteria;Caloric Restriction;Cell Aging;cell growth regulation;Cell Proliferation;cell type;Cells;Colon;Development;Diet;Dietary Intervention;Disease;Exhibits;fecal microbiota;fecal transplantation;Female;Fortification;Foundations;Functional disorder;Gene Expression;Genetic;Goals;Gram-Negative Bacteria;gut bacteria;gut microbiome;gut microbiota;Health;High Fat Diet;Human;human old age (65+);immune activation;improved;In Vitro;in vitro Assay;in vivo;Inflammation;Inflammatory;innovation;insight;Insulin Resistance;Intermittent fasting;Intervention;life span;Lipopolysaccharides;Literature;Longevity;male;Mediating;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic dysfunction;Metabolic stress;metabolome;Metagenomics;Microbe;microbial;microbial composition;microbiome;microbiome alteration;microbiome composition;microbiota;microbiota transplantation;mouse model;Mucous Membrane;Mus;novel;novel therapeutics;Obesity;old mice;Pattern;Physiological Processes;Play;Population;Production;Progeria;Property;Proteobacteria;Public Health;Research;Role;Sample Size;senescence;senescence associated secretory phenotype;senescent cell;Shotgun Sequencing;Solid;Testing;Tissues;Transgenic Mice;Transplantation

PROJECT_TITLE: Reciprocal Modulation of the Microbiome and Cellular Senescence in Metabolic Dysfunction


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE We aim to develop novel, non-invasive, clinically relevant magnetic resonance imaging (MRI) technologies to visualize therapeutic cell distribution and homing following systemic administration. If successful, the proposed work will provide scientists and clinicians with powerful and clinically translatable imaging tools to assess cell homing, survival and therapeutic efficacy and the means to accelerate therapy development. If awarded, this diversity supplement will support a meritorious graduate student towards his PhD and career goals.

PI_NAMEs: CHAPELIN, FANNY  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Academia;Acceleration;Award;Biodistribution;Biological Assay;career;CD8B1 gene;Cell Culture Techniques;Cell Therapy;Cells;Chemistry;clinical application;clinical translation;clinically relevant;Contrast Media;Derivation procedure;design;Development;Dextrans;disease model;Doctor of Philosophy;Education;experience;Future;Goals;graduate student;Growth;Homing;IL2RA gene;Image;Imaging Device;imaging modality;Imaging technology;improved;in vivo;Infusion procedures;interest;Label;Legal patent;Magnetic Resonance Imaging;Measurement;mouse model;nanoparticle;novel;Organ Transplantation;Outcome;Patients;personalized medicine;prevent;Radiation;Regulatory T-Lymphocyte;Research;response;Scientist;Solid;superparamagnetism;T-Lymphocyte;Techniques;Testing;Therapeutic;Therapeutic Uses;therapeutically effective;therapy development;Time;tool;Training;translational potential;Treatment Efficacy;uptake;Visualization;Work

PROJECT_TITLE: Magnetic resonance imaging methods to track Treg distribution and homing for clinical applications


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: Boulder

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: This supplement will expand the capabilities of CCET by adding a dedicated high-pressure freezing instrument with both electrical and light stimulation capabilities. A dedicated carbon-coater for improved preparation of various sample grids and a spare shuttle for the Aqilos FIB-SEM instrument that will minimize downtime due to shuttle damage that can occur during period of heavy usage.

PI_NAMEs: HOENGER, ANDREAS  (contact);LUGER, KAROLIN ;STOWELL, MICHAEL H. B.

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TITLE: CU Boulder Center for Cryo-ET (CCET)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(51)-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Contraception/Reproduction;Dementia;Estrogen;Heart Disease;Menopause;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sleep Research;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: SCORE NARRATIVE The Brigham and Women's Hospital/Harvard Medical School SCORE Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes will address an important knowledge gap in our understanding of how 1) social and metabolic stress exposures that are more common or unique in women result in health problems during and after menopause—bothersome hot flashes, sleep problems, body fat gain, heart disease; and 2) dissect the brain circuity’s response to stress that drives these health changes during and after menopause. Our Brigham/Harvard SCORE will catalyze women’s health and sex/gender difference research and grow the next generation of investigators in this field. Results of our studies will produce a significant public health impact in aging women by understanding the role and mechanisms of stress in producing midlife women’s health outcomes that are linked with cardiovascular disease and dementia.

PI_NAMEs: JOFFE, HADINE  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;Age;Aging;aging related;Animal Model;Animals;Basic Science;biological adaptation to stress;Biology;Body fat;Brain;Brain imaging;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;career;Clinical;Clinical Sciences;Cognition;cognitive change;Collaborations;Data;Dementia;dementia risk;Dynorphins;Education;experience;Exposure to;Fellowship;Female;gamma-Aminobutyric Acid;Gender;gender difference;Goals;Gonadal Steroid Hormones;Growth;Health;health difference;Heart Diseases;hormone therapy;Hormone use;Hospitals;Hot flushes;Human;human model;hypothalamic pituitary gonadal axis;Impaired cognition;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;Investigation;KISS1 gene;Knowledge;Leadership;life span;Link;Mediating;medical schools;Medicine;Metabolic;Metabolic stress;Midlife women;neural;neural circuit;neural network;Neurobehavioral Manifestations;Neuroendocrinology;neuroimaging;neuromechanism;Neurons;neuropsychiatric symptom;neuroregulation;Neurosciences;Neurosecretory Systems;next generation;novel;novel therapeutics;nutritional epidemiology;older women;Outcome;Perimenopause;physiologic stressor;Pilot Projects;Policies;poor sleep;Population;Population Sciences;Postmenopause;Predisposition;Pregnancy;Prevention strategy;Process;programs;Psychosocial Stress;Public Health;Quality of life;reproductive epidemiology;reproductive hormone;reproductive senescence;Research;Research Personnel;Resources;response;Rodent;Rodent Model;Role;Science;Scientist;sex;Sex Differences;Site;Sleep;Sleep Disorders;Sleep disturbances;social stress;social stressor;Stress;stressor;symptom treatment;synergism;Translational Research;translational research program;Travel;vasomotor symptoms;Woman;Women's Health;Work


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Depression;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Post-Traumatic Stress Disorder (PTSD);Primary Health Care;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE This application requests funds to refine and rigorously test a collaborative care model for patients with opioid use disorder (OUD) and major depression, post-traumatic stress disorder, or an anxiety disorder in primary care. We also will examine clinician and practice characteristics associated with successful implementation and the cost effectiveness of different care models. Successful completion of the proposed study will provide definitive evidence regarding the most parsimonious set of elements of integrated collaborative care required to maximize outcomes for individuals with OUD and psychiatric disorders.

PI_NAMEs: BOGNER, HILLARY R;KAMPMAN, KYLE MATTHEW;MANDELL, DAVID S (contact)

PROGRAM_OFFICER_NAME: FREED, MICHAEL C

PROJECT_TERMS: Address;Adoption;Affect;Anxiety;Anxiety Disorders;Attention;Buprenorphine;care coordination;Caring;Case Manager;Characteristics;Clinic;Clinical;collaborative care;community advisory board;community partnership;Consultations;cost;Cost Analysis;cost effectiveness;design;Disease;Disease remission;economic value;Effectiveness;effectiveness evaluation;Elements;Enrollment;Federally Qualified Health Center;Funding;Future;Goals;Health system;heroin use;illicit opioid;implementation determinants;implementation strategy;improved outcome;Individual;Infrastructure;Intervention;Low Prevalence;Major Depressive Disorder;Measurement;Measures;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methadone;Modeling;Morbidity - disease rate;mortality;Naltrexone;National Institute of Mental Health;opioid overdose;opioid use;opioid use disorder;Outcome;overdose death;patient engagement;Patients;Pennsylvania;Persons;Pharmaceutical Preparations;Pharmacotherapy;Philadelphia;Post-Traumatic Stress Disorders;practice setting;prescription opioid;Primary Care;primary care patient;Primary Care Physician;primary care practice;primary outcome;Probability;programs;prototype;provider factors;psychiatric comorbidity;Psychiatrist;psychosocial;Randomized;Request for Applications;Research Design;Resources;Rural;rural area;Site;social health determinants;Social Workers;suburb;Telephone;Testing;therapy design;Training;treatment as usual;treatment program;Universities;uptake;Visit;waiver;whole health;Work

PROJECT_TITLE: The Whole Health Study: Collaborative Care for OUD and Mental Health Conditions


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Post-Traumatic Stress Disorder (PTSD);Primary Health Care;Rural Health;Serious Mental Illness;Social Determinants of Health;Substance Misuse;Suicide

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Project Narrative Opioid use disorders, co-occurring with either depression or PTSD, are prevalent, burdensome, and too often left untreated. This project tests whether a collaborative care model adapted for co-occurring disorders improves access, quality and outcomes for primary care patients with co-morbid OUD and depression and/or PTSD in New Mexico. New Mexico has one of the highest opioid overdose death rates, and the CDC projects it will have the highest rates of death from drugs, alcohol and suicide in the nation by 2025.

PI_NAMEs: KOMAROMY, MIRIAM ;WATKINS, KATHERINE E (contact)

PROJECT_TERMS: Abstinence;addiction;Address;Adult;Affect;alcohol and other drug;Alcohols;behavioral health;Caring;Case Manager;Certification;Chronic;Clinical;Collaborations;collaborative care;Communities;comorbidity;Complex;contextual factors;Death Rate;Depressive disorder;Development;Disease;Drug usage;dual diagnosis;effectiveness evaluation;Evidence based treatment;experience;Family;Health;Health Personnel;health professional shortage areas;Health Sciences;Healthcare Systems;heroin use;High Prevalence;Hispanic;ideation;Improve Access;Individual;Information Systems;Intervention;Left;Link;Measurement;Mediating;Mediator;Medical;medication for opioid use disorder;Mental Depression;Mental disorders;Mental Health;Modeling;mortality;motivational enhancement therapy;New Mexico;Opioid;opioid misuse;opioid mortality;opioid overdose;opioid use disorder;Outcome;Participant;patient engagement;Patient Outcomes Assessments;patient population;Patient Self-Report;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;Pharmacotherapy;physical conditioning;Population;Post-Traumatic Stress Disorders;pragmatic randomized trial;prescription opioid;Primary Care;primary care clinic;primary care patient;primary care provider;primary outcome;Principal Investigator;problem solving therapy;Process;Provider;psychosocial;Quality of Care;Randomized;Registries;Research;Resources;Risk;Risk Factors;Rural;Safety;secondary outcome;Seminal;Service delivery model;Services;severe mental illness;Site;Stigmatization;Substance Use Disorder;Suicide;Suicide attempt;Symptoms;Testing;Training;treatment as usual;Treatment Effectiveness;Underserved Population;Universities

PROJECT_TITLE: Improving Access and Treatment for Co-occurring Opioid Use Disorders and Mental Illness


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: OVERALL: CALIFORNIA NATIONAL PRIMATE RESEARCH CENTER PROJECT NARRATIVE The California National Primate Research Center is an established national resource that has as a primary mission to improve human health and quality of life through support of exceptional nonhuman primate research programs that advance our knowledge of the causes, preventions, treatments, and cures of debilitating diseases. This mission is pursued through robust and well-developed on-site research programs, facilities, and expertise that are significantly augmented by collaborative programs that serve the greater biomedical research community. We are particularly committed to understanding health and diseases across the entire lifespan.

PI_NAMEs: ATKINSON, SIMON J. (contact)

PROGRAM_OFFICER_NAME: BUHRING, BETTINA D

PROJECT_TERMS: Address;Age;Aging;Alzheimer's Disease;Anatomy;animal care;Animal Experimentation;Animals;Appointment;Area;base;Behavior;behavioral health;biobehavior;Biological Assay;Biomedical Research;California;career;Caring;Clinical Pathology;Collaborations;college;Communicable Diseases;Communities;Core Facility;COVID-19;Dedications;Development;Disease;Education and Outreach;Elderly;Ensure;fighting;Flow Cytometry;Fostering;Funding;Genetic;Goals;Grant;Growth;Health;Health Services;high standard;Human;human disease;improved;industry partner;Information Technology;Infrastructure;Inhalation Exposure;Institution;Knowledge;Laboratories;Lead;life span;Medical;Medicine;Mentors;Mission;Modeling;Multimodal Imaging;National Institute on Aging;Neurosciences;next generation;nonhuman primate;operation;outreach;population health;Prevention;Primates;programs;psychologic;Quality of life;recruit;Regenerative Medicine;Reproductive Sciences;Research;Research Design;Research Personnel;Research Priority;Research Support;Resources;responsible research conduct;Role;Schools;Science;Scientist;Services;Site;tool;Training;translational scientist;United States National Institutes of Health;Universities;Veterinarians;Vision;ZIKA;Zika Virus


FUNDING_MECHANISM: OTHERS

ORG_DEPT: NEUROSCIENCES

PHR: No PHR

PI_NAMEs: DE BONO, BERNARD ;MARTONE, MARYANN E (contact)

PROGRAM_OFFICER_NAME: KUKKE, SAHANA NALINI

PROJECT_TERMS: data ecosystem;Funding

PROJECT_TITLE: SPARC Engagement Plan with the Common Fund Data Ecosystem


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biomedical Imaging;Breast Cancer;Cancer;Cardiovascular;Clinical Research;Estrogen;Heart Disease;Heart Disease - Coronary Heart Disease;Menopause;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Narrative New treatment recommendations for premenopausal women with high or intermediate risk hormone receptor breast cancer now include ovarian function suppression, to induce early menopause combined with anti-estrogen therapy resulting in near-complete estrogen deprivation. This abrupt menopause induction together with anti-estrogen therapy improves survival from cancer yet also places these women at risk of organ damage, including heart toxicity. Our pilot study suggests that asymptomatic declines in heart perfusion are observed over several months on this therapy. In this work we will study women with serial heart imaging to more fully understand the impact of this treatment on small and large heart vessels, as well as to study if there are patient characteristics, blood biomarkers or electrocardiogram changes which can predict who is at greatest risk for heart damage from near-complete estrogen deprivation.

PI_NAMEs: JORDAN, JENNIFER HAWTHORNE;THOMAS, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Age;Angiography;Anti-estrogen Therapy;Antineoplastic Agents;Aorta;ascending aorta;Atherosclerosis;Biological Markers;Blood;Blood Pressure;Blood Vessels;calcification;Cancer Burden;cancer survival;cancer therapy;cardiac magnetic resonance imaging;Cardiotoxicity;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Characteristics;Clinical;Coronary Arteriosclerosis;coronary calcium scoring;demographics;deprivation;Descending aorta;Development;EFRAC;Electrocardiogram;Endothelium;Estrogens;Ethnic Origin;experience;Goals;Heart;heart damage;heart imaging;High Risk Woman;Hormone Receptor;hormone receptor-positive;improved;Incidence;Inflammation;Knowledge;Left;Left Ventricular Mass;Left ventricular structure;Malignant Breast Neoplasm;Maps;Measurement;Measures;Menopause;multidisciplinary;Myocardial;Myocardial perfusion;Natural History;Organ;Ovarian;Patients;Perfusion;perfusion imaging;Physiologic pulse;Pilot Projects;potential biomarker;pre-clinical;predictive tools;Premature Menopause;Premenopause;Prevalence;pro-brain natriuretic peptide (1-76);Race;Recommendation;Recurrence;Regimen;Risk;Risk Factors;Serum;social health determinants;standard of care;Stress;Stroke Volume;Testing;Time;tool;Toxic effect;Treatment-related toxicity;trend;triple-negative invasive breast carcinoma;Troponin;United States;vascular injury;Ventricular;Woman;women's diagnosis;Women's Health;Women's study;Work;X-Ray Computed Tomography

PROJECT_TITLE: Cardiovascular Impact of Near-complete Estrogen Deprivation for Breast Cancer

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: PROJECT NARRATIVE  The establishment and maintenance of healthy cells and tissues relies on the timely transport of numerous cellular factors to their respective subcellular destinations. Highly regulated molecular motors, such as cytoplasmic dynein, ensure the appropriate delivery of such cargoes such that the final destination matches the needs of the cell. The goal of our research program is to understand how dynein is regulated with a high degree of spatial and temporal precision to ensure that inappropriate transport, which is causative of various human diseases, does not occur.

PI_NAMEs: MARKUS, STEVEN M (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Affect;Architecture;Biological;Cell Cycle;Cell Cycle Stage;Cell Differentiation process;Cell division;Cell membrane;cell type;Cells;Cortical Malformation;Cytoplasm;Defect;Destinations;Development;Disease;Disparate;Dynein ATPase;effective therapy;Ensure;Environment;Goals;Health;Homeostasis;human disease;In Vitro;insight;Life;LIS1 protein;lissencephaly;Maintenance;Mediating;Membrane;Microtubules;Mitotic spindle;Molecular;Molecular Motors;Motor;Motor Neuron Disease;Movement;neuronal cell body;Organ;Organelles;Organism;Play;Positioning Attribute;prevent;Process;programs;Proteins;Regulation;Research;Role;stem cell division;stem cells;Stratification;Tissues

PROJECT_TITLE: Regulation of Dynein-Mediated Transport


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Digital measures in Huntington’s disease, a devastating progressive neurodegenerative disorder with no cure, are needed to support remote assessments as new disease-modifying treatments emerge. For eventual use in clinical trials, these measures must first be shown to reliable, valid, and meaningful in the population of interest. Our proposal aims to establish analytical validity and meaningfulness of digital measures of gait and chorea in early Huntington’s disease.

PI_NAMEs: ADAMS, JAMIE LYNN (contact)

PROGRAM_OFFICER_NAME: LAUDA, MARK

PROJECT_TITLE: Measuring Digital Clinical Endpoints in Huntington's Disease (MEND-HD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-T (20)]


ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Our research is focused on three lipid GPCRs in inflammation and the resolution of inflammation, which represent promising targets for developing new drugs for many inflammatory disorders. We take a variety of research strategies to elucidate the structural basis for receptor function and develop new agents targeting these receptors as novel pharmacological tools. The discoveries from our research will advance our understanding of inflammation biology and facilitate the development of new drugs for controlling inflammation in numerous diseases.

PI_NAMEs: ZHANG, CHENG  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;Agonist;antagonist;Biology;C5a anaphylatoxin receptor;Cell membrane;Chemicals;CMKLR1 gene;Complex;Computational Biology;Cryoelectron Microscopy;Development;Disease;Dopamine D2 Receptor;drug candidate;Drug Controls;drug development;Family;Fatty Acids;fMet-Leu-Phe receptor;FPR2 gene;Funding;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;GPR32 gene;GPR84 gene;Immunology;Inflammation;Inflammatory;Inflammatory Response;interest;Ligands;Lipids;Macrophage;Mediator;Medium chain fatty acid;member;Molecular;Molecular Conformation;New Agents;novel;novel therapeutics;Omega-3 Fatty Acids;Peptides;Phagocytosis;Pharmaceutical Preparations;pharmacologic;Pharmacology;Process;Property;Prostaglandin D2;receptor;receptor binding;receptor function;Research;Resolution;Signal Transduction;Signaling Molecule;small molecule;structural biology;Structure;targeted agent;tool

PROJECT_TITLE: Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammation


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Hematology;Orphan Drug;Patient Safety;Physical Activity;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Patients with locally advanced rectal cancer (LARC) commonly have poor tolerability to total neoadjuvant therapy, which reduces cancer control and survival benefit of this treatment. We propose to investigate the dose- response of aerobic training (AT) on total neoadjuvant therapy tolerability in patients with LARC. Results from this investigation will identify the AT dose that maximizes total neoadjuvant therapy tolerability in LARC, and will provide essential evidence supporting integration of AT into clinical cancer care.

PI_NAMEs: CERCEK, ANDREA ;SCOTT, JESSICA  (contact)

PROGRAM_OFFICER_NAME: TESAURO, GINA M

PROJECT_TERMS: Address;Adherence;adjudication;Aerobic Exercise;Age;Anemia;Anti-emetics;Apoptosis;Attenuated;Behavior Therapy;Biological;Biological Assay;Blinded;cancer care;Cancer Control;cancer diagnosis;cancer initiation;Cancer Patient;cancer survival;cancer therapy;cancer type;Case Report Form;Cessation of life;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical practice;Clinical Research;Common Terminology Criteria for Adverse Events;Complete Blood Count;Correlative Study;Data;design;Diagnosis;digital;Disease-Free Survival;Dose;Electronics;Erythrocytes;Evaluation;Event;evidence base;Exercise;exercise intensity;Exercise Therapy;F2-Isoprostanes;Fatigue;Female;Flow Cytometry;Generations;Guidelines;Hematology;Hematopoietic stem cells;Hemoglobin;Home;Impairment;improved;In complete remission;Incidence;Induction of Apoptosis;Investigation;Knowledge;Local Therapy;male;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;meetings;Modeling;Modification;Neoadjuvant Therapy;Neutropenia;neutrophil;Oncologist;Oncology;Operative Surgical Procedures;Outcome;Pathologic;Patient Education;Patient Outcomes Assessments;patient population;Patient Schedules;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phase II/III Trial;Physiological;Pilot Projects;point of care;Postoperative Complications;preclinical study;primary endpoint;progression risk;Proliferating;Protocols documentation;psychosocial outcome;Qualifying;Quality of life;Random Allocation;randomized trial;Reactive Oxygen Species;real time monitoring;Recommendation;Recovery;Rectal Cancer;Regimen;Reporting;Research;response;Safety;Sample Size;Schedule;sex;Site;standard of care;Standardization;Structure;Survival Rate;Techniques;Testing;Time;Toxic effect;Translating;treadmill;treatment planning;Treatment-related toxicity;tumor;Walking;Work

PROJECT_TITLE: Dose-response of aerobic training during total neoadjuvant therapy for locally advanced rectal cancer


PHR: Project Narrative The ability to manipulate the expression of genes in cells and organisms is foundational to the study of genetics and to the development of gene therapies, yet simple and scalable methods to increase gene expression remain challenging. Through a combination of innovative highthroughput screens and cutting-edge computational modeling, we will develop a cohort of CRISPR-based tools that enable potent, tunable, and predictable increases in gene expression at any gene. The efforts described in this proposal will provide a next-generation gene activation toolkit with broad applicability in genetic screening and therapeutic gene activation.

PI_NAMEs: SHERWOOD, RICHARD I (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Algorithms;Architecture;Biological Assay;Candidate Disease Gene;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Communities;Computer Models;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;design;Development;epigenome;gain of function;Gene Activation;Gene Expression;Gene Silencing;gene therapy;Genes;Genetic;genetic manipulation;Genetic Screening;Genetic study;Genome;genome editing;Genomics;Guide RNA;HepG2;high throughput screening;High-Throughput Nucleotide Sequencing;Human;improved;innovation;K562 Cells;Measurement;Methods;Modeling;Monitor;Mus;next generation;novel;Organism;Outcome;Output;Peptides;Phenotype;promoter;Reporter;Repression;Reproducibility;screening;Site;System;therapeutic gene;tool;web-based tool;Work

PROJECT_TITLE: Development of potent and predictable Cas9 gene activation tools through high-throughput screening

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Rehabilitation

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Social anxiety is a common and chronic problem but, for unknown reasons, many patients do not respond to existing treatments. Despite advances in neuroscience and computational psychiatry, there remains no reliable predictor of treatment response that can be used to select an optimal treatment for a given patient. The goals of the proposed research are to examine whether neuroimaging can offer an evidence-based precision or personalized medicine approach to predict treatment in patients with social anxiety, and to apply advanced computational and multimodal imaging approaches to improve our understanding of the neurobiology of social anxiety disorder, and brain changes (plasticity) associated with treatment response.

PI_NAMEs: DILLON, DANIEL G;GABRIELI, JOHN ;ROSELLINI, ANTHONY JOSEPH (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Adult;Behavior;behavior measurement;Behavioral;biomarker identification;Boston;Brain;brain circuitry;Chronic;Clinical;Clinical Data;clinical decision-making;clinical practice;cognitive control;Cognitive Therapy;Combined Modality Therapy;comparison control;connectome;cost;Data;Diffusion Magnetic Resonance Imaging;disease classification;Distress;Doctor of Philosophy;DSM-V;effective therapy;Electroencephalography;Emotional;evidence base;Face;Feedback;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Group Therapy;Health;Hospitals;Human;Image;imaging approach;improved;improved outcome;Individual;Individual Differences;individual patient;Investigation;Left;Machine Learning;Magnetic Resonance Imaging;Massachusetts;Measurement;Measures;Mental disorders;Modeling;multimodal data;Multimodal Imaging;multimodality;Negative Valence;neural;neural circuit;Neurobiology;neuroimaging;neuromechanism;Neurosciences;optimal treatments;outcome prediction;partial response;Participant;Patient-Focused Outcomes;Patients;personalized medicine;Pharmacological Treatment;Positive Valence;precision medicine;predicting response;Prediction of Response to Therapy;predictive marker;predictive modeling;Process;Psychiatry;Psychopathology;Publishing;Recommendation;recruit;Reporting;Research;Research Domain Criteria;Research Personnel;response;Rest;reward processing;Sampling;Selective Serotonin Reuptake Inhibitor;Sertraline;Severities;skills;social anxiety;Social Anxiety Disorder;Source;Structure;success;System;systematic review;Technology;temporal measurement;Testing;Treatment Efficacy;treatment guidelines;Treatment outcome;treatment response;Universities;usability;Variant;white matter;Work

PROJECT_TITLE: Neural Markers of Treatment Mechanisms and Prediction of Treatment Outcomes in Social Anxiety

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_DEPT: BIOLOGY

PHR: Project Narrative Synthetic biology holds the promise of transforming the development of diagnostic and treatment strategies for various diseases. This project applies synthetic biology approaches to reprogram fate decisions toward progressive cellular deterioration, a key factor in many diseases, such as cancers, diabetes, and neurodegenerative diseases. Key insights obtained from this project will define foundations for chemical or gene- based strategies to treating diseases related to progressive cellular deterioration.

PI_NAMEs: HAO, NAN  (contact);HASTY, JEFF M;PILLUS, LORRAINE ;TSIMRING, LEV S

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Affect;Biological Process;Cell Death;Cell Fate Control;cell injury;Cell Reprogramming;Cells;Chemicals;Complex;Computer Models;Core Protein;Deacetylase;Decision Making;Deterioration;Diabetes Mellitus;diagnostic development;diagnostic strategy;Disease;Engineering;Eukaryota;Foundations;gene conservation;Gene Expression;gene interaction;Genes;Genetic Transcription;Growth;Heme;improved;insight;Lysine;Malignant Neoplasms;Mammals;Mediating;Microfluidics;Mitochondria;Mitotic;Modeling;Molecular;Neurodegenerative Disorders;Pattern;Phenotype;Physiological;Play;predictive modeling;Process;programs;promoter;protein expression;Proteins;Regulation;Research;Resources;Ribosomal DNA;Role;Saccharomyces cerevisiae;Structure;synthetic biology;Synthetic Genes;Time;tool;treatment strategy;Yeasts

PROJECT_TITLE: Reprogramming cell-fate decisions through predictive modeling and synthetic biology

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: TELESNITSKY, ALICE  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Biochemical;Cells;Cellular biology;Collaborations;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Development;Education;Electron Microscopy;experience;experimental study;Goals;high resolution imaging;HIV;HIV-1;Image;imaging approach;improved;In Vitro;innovation;Lead;light microscopy;Methods;Michigan;Mission;particle;programs;protein complex;Proteins;Protocols documentation;repository;Research Personnel;Resolution;Resources;RNA;Running;Sampling;Scientist;structural biology;Structure;Techniques;three dimensional structure;tool;Training;ultra high resolution;Universities;Virus;Wisconsin;Work

PROJECT_TITLE: Center for Structural Biology of HIV RNA


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Mental Health;Neurosciences

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Fear-related disorders such as Post-Traumatic Stress Disorder (PTSD) are often characterized by an inability to inhibit and extinguish fear memories leading to pathological expression of fear-related behaviors. For progress to occur with targeted rationally-designed therapeutic approaches, a greater understanding of the neural circuitry mediating fear inhibition and extinction is needed. This proposal uses cell-type specific modulation of cells within the amygdala to advance our understanding of circuitry underlying fear behaviors and will provide unique avenues for therapeutics.

PI_NAMEs: BOLSHAKOV, VADIM ;RESSLER, KERRY J. (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Affect;Amygdaloid structure;anxiety-related disorders;Behavior;Behavior Therapy;Calcium;Cell Nucleus;Cell Physiology;cell type;Cells;Chronic stress;conditioned fear;CRH gene;designer receptors exclusively activated by designer drugs;Disease;Dissection;Electrophysiology (science);Emotions;Exhibits;Exposure to;Extinction;fear memory;Fiber;Fright;Functional disorder;Future;Genes;Genetic;Genomics;Hippocampus;Impairment;Implant;in vivo;innovation;learning extinction;lens;Medial;Mediating;Memory;Methodology;Modeling;Modification;Molecular;Molecular Profiling;Molecular Target;Mus;National Institute of Mental Health;neural circuit;Neural Pathways;Neuronal Plasticity;Neurons;Neurosciences;novel;Nuclear RNA;Outcome;Pathologic;Pathway interactions;Pattern;pharmacologic;Photometry;Physiological;Pilot Projects;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;prevent;promoter;rational design;Refractive Indices;Regulation;Reporter;Research Domain Criteria;Research Priority;response;RNA;Role;Signal Transduction;Slice;Strategic Planning;Stress;Synapses;Synaptic plasticity;System;Testing;Therapeutic;tool;transcriptome sequencing;translational approach;translational study;Trauma;United States National Institutes of Health;Viral;Work

PROJECT_TITLE: Cell Type Specific Genomic and Functional Dissection of Fear-Off Amygdala Pathways

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Prevention;Women's Health Research

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Breast cancer is the leading cancer among women, accounting for one-third of diagnosed cancers. While sus- picious mammographic ﬁndings may be clariﬁed with ultrasound imaging, a subset of ultrasound images yield inconclusive results, necessitating biopsies or follow-up procedures, which increase patient anxiety and places an additional burden on the time and resources of our healthcare system. The goal of this project is to develop ultrasound technology that will resolve existing ambiguities. Project Narrative Page 7

PI_NAMEs: BELL, MUYINATU A. LEDIJU (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Accounting;Acoustics;Administrative Supplement;Anxiety;Benign;Biopsy;Breast;Breast Cancer Detection;cancer diagnosis;Clinical;clinical care;Clutterings;Complex;Cyst;Data;Development;Diagnosis;Diagnostic;Disease;Early Diagnosis;follow-up;Goals;Healthcare Systems;Human body;Image;imaging modality;Imaging technology;improved;Length;Liquid substance;Liver;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Ultrasonography;Mammography;Mass in breast;Methods;Morbidity - disease rate;mortality;novel;novel strategies;Organ;Pancreas;Patients;Performance;Procedures;Reader;Real-Time Systems;Resource Allocation;Resources;screening;Solid;Technology;Time;tool;Ultrasonography;ultrasound;Uncertainty;United States;United States National Institutes of Health;Woman

PROJECT_TITLE: Minimizing Uncertainty in Breast Ultrasound Imaging with Real-Time Coherence-Based Beamforming


NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences

PHR: PUBLIC HEALTH RELEVANCE Bipolar disorder is a devastating disease that impacts the lives of millions of people. The identification of more targeted treatments will help to minimize side effects and improve efficacy of therapeutic results. These studies will help pave the way towards the identification and development of these targeted treatments to stabilize mood and improve the lives of those suffering from this disease.

PI_NAMEs: MCCLUNG, COLLEEN A (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Acute;Animal Model;Animals;Antibodies;Anticonvulsants;Behavior;Behavioral;behavioral phenotyping;Binding;Bipolar Disorder;bipolar mania;Brain;Cell Separation;Cells;chromatin immunoprecipitation;Corpus striatum structure;deep sequencing;Development;Disease;Dopamine;dopaminergic neuron;Drug Prescriptions;efficacious treatment;Electrodes;Electrophysiology (science);Funding;Future;gamma-Aminobutyric Acid;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Goals;Grant;HDAC1 gene;Histone Acetylation;Histone Deacetylase;histone deacetylase 2;Histone Deacetylase Inhibitor;Human;improved;in vivo;inhibitor;knock-down;Location;Malignant Neoplasms;Manic;Measures;Mental disorders;Molecular;Molecular Target;Moods;mouse model;Mus;Mutation;Names;Neurons;new therapeutic target;overexpression;patch clamp;Persons;Pharmaceutical Preparations;Pharmacology Study;Phase;Phenotype;prevent;protein expression;Protein Inhibition;Proteins;Proteomics;public health relevance;Regulation;response;Rest;RNA Viruses;Series;side effect;Signal Transduction;small hairpin RNA;System;targeted treatment;Therapeutic;therapeutic candidate;Therapeutic Effect;Therapeutic Studies;therapeutic target;Therapeutic Uses;transcriptome sequencing;transmission process;Treatment Efficacy;treatment response;valproate;Valproic Acid;Ventral Tegmental Area

PROJECT_TITLE: Consequences of HDAC2 inhibition in VTA-NAc circuitry


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD);Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative There is a critical gap in knowledge about innervation of the temporomandibular joint (TMJ) tissues. Here we propose a study that will bridge this gap by comprehensively elucidating the functions, types, neuroanatomical distributions, and plasticity of trigeminal neurons innervating muscle, tendon, and fascia of the masseter and lateral pterygoid muscles, as well as the cartilage, joint capsule, and ligament around the TMJ condyle. Our findings will fulfil all objectives of RE-JOIN program, lead to a better mechanistic understanding of the development of temporomandibular joint disorder (TMJD) pain and translate to improved prevention and management of TMJD pain.

PI_NAMEs: AKOPIAN, ARMEN N (contact);MACPHERSON, LINDSEY J

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Afferent Neurons;aged;Animal Model;Antibodies;Back;Behavioral;Biopsy;Callithrix;candidate identification;candidate marker;Cartilage;Cells;clinical development;clinically relevant;Communities;Computer software;Data;data harmonization;Data Set;Development;Diagnosis;disease model;Diskectomy;Electrophysiology (science);experience;experimental study;Fascia;Female;Fiber;Fluorescent Dyes;Goals;Human;human tissue;IACUC;Immunohistochemistry;improved;in vivo;in vivo imaging;Joint Capsule;Knowledge;Lateral;Lead;Ligaments;Light;Location;male;Manuals;Maps;Mediator;Metadata;Microscopy;Modality;Molecular Profiling;mouse model;multidimensional data;multidisciplinary;Mus;Muscle;Myofascial Pain Syndromes;nerve supply;Nerve Tissue;Neurites;Neuroanatomy;Neurons;new therapeutic target;nonhuman primate;novel;old mice;Pain;Pain Free;pain patient;Patients;Phenotype;Physiological;Prevention;Primates;programs;Property;Protocols documentation;Pterygoid Muscle;Publishing;receptor;Reporter;Research;Resolution;Sensory;single cell sequencing;Spinal Ganglia;Techniques;Temporomandibular Joint;Temporomandibular joint disorder pain;Temporomandibular Joint Disorders;Tendon structure;therapeutic candidate;therapeutic target;tibialis anterior muscle;Tissues;tool;transcriptome sequencing;Translating;Trigeminal System;Visualization;Work

PROJECT_TITLE: Comprehensive functional phenotyping of trigeminal neurons innervating temporomandibular joint (TMJ) tissues in male, female and aged mice, primates, and humans with and without TMJ disorders (TMJD)


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: Chapel Hill

ORG_NAME: QATCH TECHNOLOGIES, LLC

PHR: Subcutaneous injections of protein-based therapeutics enable home administration and reduce the load on the healthcare facilities and healthcare costs. However, the injectability of protein-based formulations at the necessary high concentrations for injection cannot be determined at early stages of drug development due to a lack of material. Thus, protein molecules cannot be optimized or selected for injectability. Our technology addresses this by allowing the measurement of viscosity at shear-rate ranges relevant to injectability and manufacturability using very small volumes of formulations. Selling this product involves reaching out pharmaceutical companies and CDMO/CROs, developing proper messaging, and iterating through the interactions and finalizing towards cash flow. This project will help us commercialize this unique technology, which in turn will benefit drug development and consequently patient experience and adherence.

PI_NAMEs: PARLAK, ZEHRA  (contact)

PROGRAM_OFFICER_NAME: BILLINGSLEA, EDDIE

PROJECT_TERMS: Address;Adherence;Biological Products;commercialization;drug development;experience;Feedback;Formulation;Health Care Costs;Health care facility;Home;Industry;Injectable;Injections;manufacturability;Marketing;Measurement;Microfluidics;Patients;Pharmacologic Substance;protein protein interaction;Proteins;prototype;Quartz;Rheology;Sales;Sampling;scale up;screening;Subcutaneous Injections;Techniques;Technology;Therapeutic;Viscosity;Work

PROJECT_TITLE: High-throughput injectability screening of high concentration protein formulations by microfluidic quartz resonators


NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PI_NAMEs: ARDLIE, KRISTIN  (contact)

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: Address;Adult;analysis pipeline;Area;Benchmarking;biobank;Calendar;Child;ChIP-seq;cloud platform;cohort;Collaborations;Collection;Communities;Complex;computing resources;cost;Data;data access;Data Analyses;data ecosystem;data exploration;Data Protection;data resource;Data Set;data tools;database of Genotypes and Phenotypes;Deoxyribonuclease I;Development;Disease;DNA Methylation;DNA sequencing;Education and Outreach;Educational workshop;Enrollment;exome;exome sequencing;Exons;experimental study;Funding;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic study;Genetic Variation;Genotype;Genotype-Tissue Expression Project;Goals;Histology;Histones;Human;Human BioMolecular Atlas Program;human tissue;Hypersensitivity;Image;Inherited;insight;interactive visualization;interest;Joints;large datasets;Link;Mass Spectrum Analysis;Measurement;Metadata;Molecular;Normal tissue morphology;Organ;Paper;Pediatric Neoplasm;Play;Predisposition;Process;Production;Protein Isoforms;Proteomics;Publishing;Quantitative Trait Loci;Resources;RNA Sequences;RNA Splicing;Role;Sampling;Site;Testing;The Cancer Genome Atlas;Tissue Sample;Tissues;tool;Training;Trans-Omics for Precision Medicine;Transcript;transcriptome sequencing;tumor;United States National Institutes of Health;Visualization;whole genome;Work

PROJECT_TITLE: GTEx engagement with the CFDE-CC and other DCCs towards building a data ecosystem spanning the Common Fund projects


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Rare Diseases

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The proposed research seeks to improve the ability to observe interactions between biological molecules through the development of novel chemical tools. Success would increase our knowledge of cell biology, leading to an improved understanding of human disease and possible therapeutic interventions.

PI_NAMEs: DEVARAJ, NEAL KRISHNA (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TITLE: Illuminating cellular dark matter through the development of novel chemical tools

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This project strives to understand the mechanisms that regulate protein synthesis. Deregulation of the protein synthesis machinery is associated with diseases such as cancer, ribosomopathies, and metabolic disorders. Uncovering the process of translational control will help to identify novel therapeutic targets.

PI_NAMEs: ORIGANTI, SOFIA  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Affect;Allosteric Regulation;Binding;Biochemical;Biophysics;cancer cell;Cell Nucleolus;Cell Survival;Childhood Leukemia;Complex;Data;Disease;Ensure;Eukaryotic Initiation Factors;Growth;Guanosine Triphosphate Phosphohydrolases;Impairment;in vivo;insight;Malignant Neoplasms;Messenger RNA;Metabolic Diseases;Molecular;Mutation;new therapeutic target;novel;Phenotype;Prognosis;Protein Biosynthesis;Protein Deregulation;Quality Control;Regulation;Ribonucleoproteins;Ribosomal RNA;Ribosomes;ribosomopathy;Role;RPL10 gene;Shwachman-Diamond syndrome;single molecule;Site;Therapeutic;therapeutic development;Trans-Activators;Translation Initiation;Translation Process;Translations;Work

PROJECT_TITLE: Mechanism and Regulation of eIF6 in Translation


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Narrative for administrative supplement request for GM-15792-57 We request funds to enable the purchase of a replacement surface plasmon resonance (SPR) instrument that will support our ongoing studies of DNA structure and dynamics within functional protein-DNA complexes using fluorescent probe-substituted DNA constructs with advanced spectroscopic techniques. These complexes operate as ‘macromolecular machines’ within living cells to faithfully replicate (copy) the DNA genome into the daughter cells during cell division, to transcribe and process specific messenger RNA sequences to permit ‘expression’ of defined genes, and to direct the synthesis of specific required proteins at various stages of development. The requested supplementary funds will permit us to replace aging equipment that is central to a program of research that uses the methods of physics and chemistry to understand the molecular processes that are involved in the function and regulation of these macromolecular machines of genome expression, in part because understanding these central processes in molecular detail will help in the development of specific tools to control diseases of anomalous gene expression and development, including various forms of cancer and related genetic disorders.

PI_NAMEs: MARCUS, ANDREW HADLEY (contact);VON HIPPEL, PETER H

PROJECT_TERMS: 15 year old;Administrative Supplement;Aging;analog;analytical tool;Bacteriophage T4;base;Base Pairing;Binding Proteins;Binding Sites;Businesses;Cell division;Cells;Chemistry;Complex;Consumption;daughter cell;Development;disorder control;DNA;DNA biosynthesis;DNA replication fork;DNA Structure;DNA-Protein Interaction;Dyes;Equilibrium;Equipment;exhaust;experience;experimental study;Fluorescent Probes;Funding;Gene Expression;Genes;Genetic Diseases;Genetic Transcription;Genome;Grant;Guanine;instrument;Knowledge;Label;Laboratories;Maintenance;Malignant Neoplasms;Manuals;Manufacturer;Measurement;Messenger RNA;Methods;Microfluidics;Modeling;Molecular;Molecular Conformation;Monitor;National Institute of General Medical Sciences;Nucleic Acids;Optics;Physics;Positioning Attribute;Process;programs;Property;Proteins;Regulation;Research;RNA Sequences;Running;Sampling;single molecule;Site;Structure;Surface Plasmon Resonance;System;Techniques;Time;tool;Universities;Vertebral column;Work

PROJECT_TITLE: Structure and Relations of Protein and Nucleic Acids


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The overarching aim of this application is to uncover molecular mechanisms by which Retinoblastoma and Hippo pathways regulate cell proliferation and differentiation during Drosophila development. This knowledge will help to advance the understanding of normal development and animal physiology and provide insights into fundamental regulatory growth mechanisms that may go awry in human disease.

PI_NAMEs: FROLOV, MAXIM  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Adult;Animals;Area;Binding;Biological Models;Biological Process;Cell Cycle Regulation;Cell Differentiation process;Cell Proliferation;Cells;Chromatin;Compensation;Coupled;Development;Differentiation and Growth;Disease;Drosophila genus;Enhancers;epigenomics;Event;experimental study;Eye;Family;fly;Future;Gene Expression;Genes;genetic analysis;Genetic Transcription;Genomic approach;Goals;Growth;human disease;insight;interest;Knowledge;Malignant Neoplasms;Metabolic;Molecular;Muscle;Muscle Development;Nucleic Acid Regulatory Sequences;Organism;Orthologous Gene;Pathway interactions;Phenotype;Photoreceptors;Physiology;Process;progenitor;programs;Proteins;Research;Retinoblastoma;Retinoblastoma Genes;retinoblastoma pathway;Retinoblastoma Protein;Role;Signal Pathway;single cell genomics;Skeletal Muscle;stem cells;Tissues;transcription factor;Transcriptional Regulation

PROJECT_TITLE: Control of cell proliferation and differentiation by growth pathways


ORG_CITY: TUSCALOOSA

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: Project Narrative This project establishes the rules for integrated design of a platform technology for oral delivery of pharmaceutical drugs with diverse physicochemical attributes. In doing so we will develop a mathematical model that can significantly advance the discovery, development, and preclinical-to-clinical translation of drug- laden polymer nanoparticles designed for oral administration.

PI_NAMEs: MAJETI, RAVIKUMAR N (contact);SHAH, DHAVAL K

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: ABCB1 gene;absorption;Administrative Supplement;Affinity;amphiphilicity;Behavior;Binding Sites;Biological Availability;Blood;Blood - brain barrier anatomy;Blood-Retinal Barrier;Canis familiaris;Cannulations;Cells;Characteristics;Chemistry;clinical practice;clinical predictors;clinical translation;Cyclosporine;Data;data modeling;density;design;Designer Drugs;Development;Dose;Drug Carriers;Drug Delivery Systems;drug repurposing;Drug Transport;drug-like compound;Encapsulated;Engineering;Excipients;Exhibits;extracellular;Family suidae;flexibility;functional group;gambogic acid;Goals;Growth;Health Technology;Human;hydrophilicity;improved;in silico;In Vitro;in vivo;insight;Intestines;Investigation;Knockout Mice;Knowledge;Lead;Length;Ligand Binding;Ligands;lymphatic duct;mathematical model;Mathematics;Mechanics;Mediating;Metabolism;Modeling;Modification;mouse model;Mus;nanocarrier;nanomedicine;nanoparticle;nanopolymer;Nanostructures;nanosystems;new chemical entity;next generation;novel;novel strategies;Oral;Oral Administration;Peptide Hydrolases;Performance;Periodicals;Pharmaceutical Preparations;pharmacokinetic model;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;physiologically based pharmacokinetics;Physiology;Polyesters;Polymers;Portal vein structure;pre-clinical;Process;Property;Race;rational design;Rattus;receptor;Receptor Cell;receptor mediated endocytosis;Regimen;Research;Research Personnel;Rodent;Role;Route;Scheme;Series;small molecule;stoichiometry;Structure;Structure-Activity Relationship;Surface;System;Tea;technology platform;TFRC gene;Toluene;tool;trafficking;transcytosis;Transferrin;Translations;uptake;Vertebral column;Work

PROJECT_TITLE: Proposal for Administrative supplement to Purchase NanoSight Pro

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Narrative Statement We propose continuation of M-CERSI that fosters FDA-oriented research, as well as regulatory science information sharing opportunities. The Center's mission is to foster the development of regulatory science – the science of developing new tools, standards and approaches to assess the safety, efficacy, quality and performance of FDA-regulated products. Activities leverage the close geographic proximity between University of Maryland and FDA's main campus.

PI_NAMEs: BENTLEY, WILLIAM E.;POLLI, JAMES E (contact)

PROGRAM_OFFICER_NAME: SEPULVEDA, KRISTIN

PROJECT_TITLE: University of Maryland Center of Excellence in Regulatory Science and Innovation


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: PENDLETON, RICHARD  (contact)

PROJECT_TITLE: FY23 FACILITIES TO-A


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: This project will develop essential preclinical data on a new therapeutic agent, fasudil, for the treatment of Alzheimer’s disease (AD). Currently there is no cure for AD. There is a huge unmet need for safe and effective therapies to treat and prevent AD. Clinical trials of fasudil for AD have been approved in China and Japan, but not in the USA. This project will study the pharmacology and toxicity of fasudil to prepare for the USA FDA application for AD clinical trials. Amyloid β protein (Aβ)-containing plaques and hyperphosphorylated Tau- containing neurofibrillary tangles are two hallmarks of AD. Our recent publication shows that fasudil efficiently removed β-amyloid pathology in brains of a transgenic mouse model for AD. We hypothesize that fasudil blocks Planar Cell Polarity (PCP)) Wnt signaling and Dickkopf-1 (Dkk1), leading to reduced Aβ pathology and increased synaptic stability. Here we also propose to analyze the effects of fasudil on Tau-tangles.

PI_NAMEs: MORIN, PETER MORIN;XIA, WEIMING  (contact)

PROJECT_TERMS: 3xTg-AD mouse;Acute;AD transgenic mice;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapeutic;Amyloid beta-Protein;amyloid pathology;Area Under Curve;beta amyloid pathology;beta catenin;Biological;Biological Assay;Biological Availability;Brain;Cells;China;Chronic;Clinical Trials;Data;Disease;disease model;dosage;Dose;Drug Kinetics;effective therapy;efficacy evaluation;Europe;experience;fasudil;Felis catus;Goals;Half-Life;hyperphosphorylated tau;Japan;Measures;Memory;Modeling;Molecular Biology;molecular pathology;Monitor;mouse model;Mus;Neurofibrillary Tangles;neuropathology;novel;novel therapeutics;Oral;Outcome;Pathology;Pathway interactions;Permeability;Pharmacodynamics;pharmacologic;Pharmacologic Substance;Pharmacology Study;planar cell polarity;Plasma;Positioning Attribute;pre-clinical;Preclinical Drug Development;prevent;promoter;Publications;Regulation;Senile Plaques;Synapses;tau Proteins;tau-1;Testing;Therapeutic Agents;Therapeutic Index;Time;Toxic effect;Transgenic Mice;United States Food and Drug Administration;WNT Signaling Pathway

PROJECT_TITLE: Exploring Alzheimer Therapeutics


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: RICE UNIVERSITY

PHR: PROJECT NARRATIVE Cancer cells differ in their mechanical properties depending on their metastatic potential when measured in vitro. Understanding the role that a cell’s mechanotype plays in vivo at each step of the metastatic cascade will be critical for developing new diagnostics and therapeutic targets for metastatic disease, the cause of a majority of cancer-related deaths. This proposal seeks to understand the heritability of cell stiffness and the advantage or disadvantage conferred by cell stiffness to metastasis through the combination of high-throughput microfluidic mechanical screening, in vivo mouse metastasis models, and multi-omic analyses.

PI_NAMEs: YOUNG, KATHERINE M (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: 4T1;Abate;ATAC-seq;Atomic Force Microscopy;Autopsy;bioluminescence imaging;Biomechanics;biophysical properties;Blood;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Cancer Biology;cancer cell;Cancer Model;career;cell behavior;Cell Death Process;Cell division;Cell Line;Cell Separation;Cells;Cessation of life;Circulation;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;CXCR4 gene;Data;Development;Devices;differential expression;Disadvantaged;Disease;Dissection;Disseminated Malignant Neoplasm;Distant;driving force;Dyes;Endothelium;Engineering;Epigenetic Process;epigenome;experimental study;Extravasation;Fatty acid glycerol esters;Fellowship;Flow Cytometry;Genes;Genetic;Genotype;Germ Cells;Goals;Heritability;immune function;In Vitro;in vitro Assay;in vitro Model;in vivo;in vivo Model;Individual;inhibitor;interest;Knowledge;Label;Link;Location;Luciferases;Lung;Malignant Neoplasms;mammary;MCF7 cell;MDA MB 231;Measures;mechanical properties;Mechanics;Microfluidic Microchips;Microfluidics;Migration Assay;Modeling;Molecular;Monitor;mouse model;multiple omics;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel diagnostics;old mice;orthotopic breast cancer;Phenotype;Play;Population;Positioning Attribute;Primary Neoplasm;Process;promoter;Property;Proteins;Proteomics;Research;Research Personnel;Resort;RNA Interference;Role;screening;Site;skills;Sorting;subcutaneous;Testing;Therapeutic;Therapeutic Effect;Time;Tissues;Training;transcriptome;transcriptome sequencing;tumor;Work;wound healing

PROJECT_TITLE: Phenotypic sorting of cancer cells to study the role and control of cell stiffness in the in vivo metastatic cascade

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Our project is focused on elucidating how copper ionophores kill cancer cells. Our genetic and functional analyses suggest that copper ionophores bring copper to the mitochondria where it is reduced by the mitochondrial ferredoxin 1 (FDX1) promoting engagement and aggregation of lipoylated DLAT (a crucial component of the pyruvate dehydrogenase complex) resulting in a new form of regulated cell death, which we have termed ‘cuproptosis.’ In this project, we propose to study the mechanism regulating cuproptosis both in cell culture and in vivo, to set the mechanistic foundation for future development of copper ionophores as a cancer therapeutics.

PI_NAMEs: SANTAGATA, SANDRO ;TSVETKOV, PETER  (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: Address;Affect;Amino Acids;Anabolism;Animal Model;Animals;Apoptosis;Binding;Biological Markers;biomarker driven;biophysical properties;cancer cell;Cancer Cell Growth;Cancer cell line;cancer type;Carbon;Cell Culture Techniques;Cell Death;Cell Death Induction;cell type;Cells;Characteristics;Citric Acid Cycle;clinical development;Clinical Trials;Coenzymes;Collaborations;Complex;Copper;Data;Dependence;design;Development;drug mechanism;Drug resistance;Enzymes;Failure;Ferredoxin;Foundations;Future;Genetic;Genetic Screening;Genomics;Goals;high resolution imaging;imaging approach;in vivo;in vivo Model;interdisciplinary approach;Ionophores;Kinetics;Knowledge;Link;Lipids;Lysine;Malignant Neoplasms;Maps;Mediating;Mediator;Metabolic;metabolomics;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;multiplexed imaging;Mus;mutant;Mutation;mutation screening;Neoplasm Metastasis;Normal tissue morphology;Organ;Pathway interactions;Patient Selection;patient subsets;Phase Transition;Physical condensation;Post-Translational Protein Processing;predictive modeling;prevent;protein protein interaction;Proteins;Proteomics;Pyruvate Dehydrogenase Complex;Qualifying;Regulation;Research;Resolution;Role;Science;single cell analysis;Site;Solid;Structure;Testing;Therapeutic;Tissue imaging;Toxic effect;transcriptome sequencing;tumor;tumor microenvironment;Tumor Tissue;tumor xenograft;Validation;whole genome

PROJECT_TITLE: Mechanisms Promoting Copper Dependent Cell Death in Cancer

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


NIH_SPENDING_CATS: Bioengineering;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: Narrative Microscopy images of cells, when analyzed by computers, can reveal powerful information about a cell. They can reveal a breadth of information about a cell’s response to changes: whether a disease, a change in their genes, or treatment by a drug. The project will develop new algorithms and test various applications using image data, aiming to accelerate biological discoveries and drug development.

PI_NAMEs: CARPENTER, ANNE E. (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Affect;Algorithms;Biological;Biological Assay;biological research;Cells;cellular imaging;Chemicals;Computer software;Computers;Data;Data Sources;deep learning algorithm;deep learning model;deep neural network;Disease;drug development;drug discovery;feature extraction;gene function;Genes;Genetic;Image;interest;invention;Learning;Location;Measures;Methods;microscopic imaging;Morphology;multimodality;novel;Organism;Paint;Pathway interactions;Pharmaceutical Preparations;Phenotype;predictive modeling;predictive test;public-private partnership;Research;response;scale up;small molecule;Stains;Structure;Techniques;Technology;Testing;Toxic effect;Training;virtual screening;Visualization

PROJECT_TITLE: Advancing image-based profiling


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: TULSA

ORG_NAME: LAUREATE INSTITUTE FOR BRAIN RESEARCH

ORG_STATE: OK

PI_NAMEs: BERG, HANNAH E (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Address;Affective;Attention;Behavior;Behavioral;Biological Markers;Characteristics;cingulate cortex;compulsion;Corpus striatum structure;Decision Making;Development;Distress;effective therapy;experimental study;Functional impairment;Functional Magnetic Resonance Imaging;Funding;health assessment;Heterogeneity;Impairment;improved;Individual;Knowledge;Literature;Measures;Mental Health;neural;neural circuit;Neurobiology;neuroimaging;Neurology;neuromechanism;Neurosciences;novel;Obsessive-Compulsive Disorder;outcome prediction;Participant;Pattern;Pilot Projects;Process;Psychiatric Diagnosis;psychologic;Research;response;Rest;Safety;Severities;Source;Stimulus;therapy development;Treatment outcome

PROJECT_TITLE: Neurology of Effortful Neutralization of Threat in Obsessive-Compulsive Disorder


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Mental Health;Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: GUEGUEN, MAËLLE CAMILLE MARIE (contact)

PROJECT_TERMS: Abstinence;Address;Adult;Affective;amphetamine use;Anterior;Anxiety;Area;arm;Autobiography;Behavior;Behavioral;Brain;Brain region;cingulate cortex;cognitive process;Corpus striatum structure;craving;Decision Making;Disease;drug reward;Drug usage;effective intervention;Experimental Designs;Functional Magnetic Resonance Imaging;Goals;health assessment;Impaired cognition;improved;Individual;innovation;Insula of Reil;Intervention;Learning;Life;Link;Measures;memory recall;Mental Depression;Mental Health;Methamphetamine;Moods;negative affect;Neuronal Dysfunction;neuropsychiatric disorder;Neurosciences;non-drug;Outcome;overdose death;Pharmaceutical Preparations;Psychological reinforcement;Public Health;Relapse;Research Domain Criteria;response;reward processing;Rewards;Signal Transduction;United States National Institutes of Health;Withdrawal

PROJECT_TITLE: Modulating explore-exploit biases by improving mood in adults with amphetamine use disorder


NIH_SPENDING_CATS: Infant Mortality;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_CITY: BINGHAMTON

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: PROJECT NARRATIVE This project requests a crystallization robot hat will significantly benefit the proposed research activities of an NIGMS-funded project. Results will establish molecular mechanisms that control dynein and kinesin-1- dependent motility, which can be targeted to treat devastating neuromuscular diseases, including amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia and spinal muscular atrophy, which is the most common genetic cause of death in infants.

PI_NAMEs: SOLMAZ, SOZANNE R (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Adaptor Signaling Protein;Amyotrophic Lateral Sclerosis;Biological Models;Brain;Cause of Death;Cell Cycle;Cell Nucleus;Cells;Chromosome Segregation;Collaborations;Complex;Consumption;Crystallization;Culicidae;Development;Disease;Drops;Dynein ATPase;Escherichia coli;Event;Funding;Genetic;Hereditary Spastic Paraplegia;human disease;Infant Mortality;Insecta;insight;Kinesin;Length;Manuals;Molecular;Motility;Motor;Muscle;Muscle Development;Mutation;National Institute of General Medical Sciences;Neuromuscular Diseases;parent grant;Pathway interactions;Positioning Attribute;Process;protein complex;protein purification;Proteins;reconstitution;recruit;Regulation;Reproducibility;Research Activity;Robot;Sampling;Signal Transduction;Spinal Muscular Atrophy;Structure;Synapses;System;Time;transmission process;Work;X-Ray Crystallography

PROJECT_TITLE: Regulation of  bidirectional transport of the nucleus by adapter proteins


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE Mandibulofacial anomalies are common birth defects that require comprehensive, sometimes repetitive corrective surgeries to manage individual cases, often placing a heavy financial and emotional burden on patients and their families. Development of therapeutic efforts requires a thorough understanding of craniofacial development and the timing of events in dysmorphogenesis. We offer innovative approaches for determining the molecular, cellular, and developmental bases of mandibulofacial morphogenesis critical to craniofacial development, in normal individuals and in craniofacial conditions such as Pierre Robin.

PI_NAMEs: JABS, ETHYLIN WANG (contact);KAWASAKI, KAZUHIKO ;PERRINE, SUSAN MARIE

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: 22q11.2;3-Dimensional;Acids;Affect;Alleles;Anatomy;Apoptosis;base;bone;campomelic dysplasia;Candidate Disease Gene;Cartilage;Cell Physiology;Cells;Cleft Palate;Complex;Congenital Abnormality;craniofacial;craniofacial development;Crowding;Data;Databases;design;Development;Developmental Process;Diagnosis;Disease;Dissection;Dysmorphology;Embryo;embryo tissue;Emotional;Etiology;Event;Face;Family;Floor;follow-up;Frequencies;Gene Expression;Gene Expression Profiling;Gene Mutation;Genes;Genetic;Genetic Transcription;genetic variant;Goals;Histologic;histological studies;Human;human data;Image;Immunohistochemistry;In Situ Hybridization;Incidence;Individual;Informatics;innovation;International;Investigation;Jaw;Knock-out;Knockout Mice;Label;laser capture microdissection;Length;Mandible;Mandibulofacial Dysostosis;Manuals;Methods;microCT;Micrognathism;Modeling;Molecular;Morphogenesis;Morphology;mouse genome;mouse model;Mus;Muscle;mutant;Mutant Strains Mice;Mutation;novel;Obstruction;Online Mendelian Inheritance In Man;Operative Surgical Procedures;palatal shelves;Palate;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;Pattern;Perinatal mortality demographics;Phenotype;Pierre Robin Syndrome;prenatal;Process;Production;programs;Proliferating;Protocols documentation;PubMed;Reporting;respiratory;response;Robin bird;Severities;Signal Pathway;Signal Transduction;Site;skull base;Syndrome;Systems Biology;Testing;therapeutic development;Time;Tissue Differentiation;Tissue-Specific Gene Expression;Tissues;Tongue;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Visualization

PROJECT_TITLE: Genetic, Tissue, and Anatomical Interactions in Mandibulofacial Dysmorphogenesis

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Colorectal Cancer;Digestive Diseases;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE The burden of cancer in Nigeria, Africa’s most populous country, is large and growing, and there is a need for increased research capacity to generate evidence to inform effective treatments, cancer control programs, and policies. To meet this need, we will leverage a highly successful research partnership between Memorial Sloan Kettering Cancer Center (US), Obafemi Awolowo University (Nigeria), and the College of Medicine at the University of Lagos (Nigeria) to establish an international research training program aimed at creating a cohort of highly skilled Nigerian investigators able to lead independent oncology research programs, fostering team science, bolstering research administration capacity in Nigeria, and creating long-term research partnerships between Nigerian and US cancer researchers.

PI_NAMEs: ALATISE, OLUSEGUN ISAAC;KINGHAM, T PETER (contact)

PROGRAM_OFFICER_NAME: SIVARAM, SUDHA

PROJECT_TERMS: Administrative Supplement;Africa South of the Sahara;anti-cancer research;Area;Award;Behavioral Sciences;Biometry;cancer clinical trial;cancer epidemiology;Clinical;Clinical Trials;Collaborations;college;Colorectal Cancer;Country;design;Development;Discipline;Discipline of Nursing;Doctor of Philosophy;E-learning;Educational workshop;Evidence based intervention;Foundations;Goals;hands on research;Health;Health Policy;Incidence;Individual;Infrastructure;Institution;interest;Malignant Breast Neoplasm;Malignant Neoplasms;medical specialties;Medicine;meetings;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;multidisciplinary;Nigeria;Nigerian;Nurses;Nursing Faculty;Oncology;Outcome;Physicians;programs;Public Health;Research;Research Personnel;Research Project Grants;Research Training;response;Science;Solid;Teaching Hospitals;Training;Training Programs;Universities

PROJECT_TITLE: Administrative supplement to expand cancer clinical trial capacity in sub-Saharan Africa


NIH_SPENDING_CATS: Cancer

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE: Exosomes play an important role in many pathophysiological processes such as neurodegeneration and cancer immune suppression. Studying the molecular basis and regulatory mechanisms of exosome trafficking will help us understand how cancer cells use exosomes for their progression. The study will bridge basic exosome cell biology and cancer biology. A protein and nucleotide acid quantification device is a basic lab equipment essential for our study of the biogenesis, secretion and function of exosomes proposed in my R35 grant.

PI_NAMEs: GUO, WEI  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Acids;Affect;Biochemistry;Biogenesis;Cancer Biology;cancer cell;Cell secretion;Cells;Cellular biology;Devices;Documentation;Equipment;exosome;extracellular vesicles;Functional disorder;Funding;Gel;Goals;Grant;Image;Immunosuppression;laboratory equipment;Malignant Neoplasms;Messenger RNA;Molecular;Molecular Biology;Molecular Cloning;Nerve Degeneration;Nucleotides;Oncogenic;Parents;Play;Process;Protein Analysis;Proteins;Regulation;Role;Signal Transduction;Signaling Protein;System;trafficking

PROJECT_TITLE: Molecular Basis and Regulatory Mechanisms of Exosome Secretion


NIH_SPENDING_CATS: Asthma;Digestive Diseases;Food Allergies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The mucosal type 2 immune response is essential to orchestrate immunity to helminth infection, but if dysregulated can drive chronic allergic diseases such as asthma or food allergy. These infections and allergic diseases impact over 2 billion individuals in the world, representing a major socio-economic and public health challenge. The fundamental focus of this application is the define two novel pathways that critically regulate type 2 mucosal immunity and inflammation, which could provoke novel preventative, therapeutic or curative treatment strategies for these infectious and inflammatory diseases.

PI_NAMEs: ARTIS, DAVID  (contact);SONNENBERG, GREGORY F

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;Allergic Disease;Allergic inflammation;Asthma;Award;career;Chronic;Communicable Diseases;Critical Pathways;curative treatments;Disease;Food Hypersensitivity;Gastrointestinal tract structure;helminth infection;Helminths;Human;Immune response;Immune system;Immunity;Immunology;Individual;Infection;Inflammation;Inflammatory;innovation;Invaded;Knowledge;Mediating;Molecular;Mucosal Immunity;mucosal site;Mucositis;Mucous Membrane;Mus;Nervous System;neurotransmission;next generation;novel;Parasites;pathogen;Pathway interactions;Public Health;response;Sampling;Signal Transduction;socioeconomics;Therapeutic;therapeutic target;tool;Translating;treatment strategy

PROJECT_TITLE: MIST Early Career Scholar Awards in Mucosal Immunology


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Infectious Diseases;Neurosciences;Pediatric;Pediatric - AIDS

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative In this project, we propose to examine in detail the early dynamics and neuroinflammation of CNS infection in the SHIV infant macaque model established at the ONPRC. We have established unique molecular approaches to delineate CNS infection and reservoirs and their changes responding to treatment.

PI_NAMEs: CHAHROUDI, ANN M;PERSAUD, DEBORAH  (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: Adolescent;Anti-viral Agents;Bar Codes;Binding;Bioinformatics;Biological Assay;Brain;Cells;Central Nervous System;Central Nervous System Infections;Childhood;Clonal Expansion;Clone Cells;collaboratory;Development;Early treatment;Effectiveness;Frequencies;Genes;HIV;Immunotherapeutic agent;improved;Infant;Infection;integration site;Intervention;Knowledge acquisition;Libraries;Macaca;Modeling;Molecular;Molecular Biology;mortality;nanocapsule;Nervous System Disorder;neurodevelopment;neuroinflammation;novel;novel therapeutic intervention;Nucleotides;Peripheral;Population;Sequence Analysis;simian human immunodeficiency virus;success;Technology;Testing;Therapeutic;Tissues;Viremia;Virus;Virus Integration

PROJECT_TITLE: Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney Collaboratory