ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative: Magnetic resonance imaging (MRI) is an important tool for imaging babies and monitoring brain development that influences long-term health outcomes. This project is to develop a novel quantitative MR scan called MR Fingerprinting tailored for baby imaging and use this scan to assess babies with opioid exposure. The goal is to use this technique to identify babies with high risk for developmental delays who may benefit from early intervention.

PI_NAMEs: MA, DAN  (contact);WILSON-COSTELLO, DEANNE E;YAP, PEW-THIAN

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: 2 year old;3-Dimensional;Address;Adoption;Adult;analysis pipeline;antenatal;Axon;Behavior assessment;behavioral outcome;Birth;Brain;Brain imaging;Brain region;brain tissue;brain volume;Categories;Child;Child Development;Child health care;Clinical;cognitive testing;contrast imaging;Correlation Studies;Data;Development;Developmental Delay Disorders;Diagnosis;Diffusion;Disease;Early Diagnosis;Early Intervention;Evaluation;Failure;Fingerprint;Goals;Health;High birth weight infant;high risk;Hospitals;Image;Image Analysis;image processing;imaging biomarker;Imaging Device;Imaging Techniques;improved;improved outcome;Industry;Infant;insight;Intervention;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;Monitor;Morphologic artifacts;morphometry;Motion;multidimensional data;Myelin;myelination;Myf-6 myogenic factor;Neonatal;neonate;Nervous System Physiology;neuroimaging;Neurologic;Newborn Infant;novel;opioid exposure;opioid withdrawal;Outcome;Outcome Assessment;patient population;Patient risk;Pattern;pediatric patients;Physiological;predictive modeling;Procedures;Property;Protocols documentation;quantitative imaging;quantum;radiologist;Reading;recruit;Relaxation;Reproducibility;Research;Resolution;Risk;risk prediction;Scanning;Sedation procedure;Seizures;serial imaging;Site;Sleep;Spasm;spatiotemporal;Stress;Structure;success;System;T2 weighted imaging;Techniques;Therapeutic;Time;tissue mapping;Tissues;tool;treatment response;usability;Variant;Vendor;Visualization;volunteer;Water;white matter;Withdrawal Symptom

PROJECT_TITLE: Comprehensive MR Fingerprinting for Infants and Young Children at Risk for Developmental Delays.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: TYLER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed studies will address the pathophysiological significance and therapeutic potential of our recent novel observations that clotting factor VIIa releases extracellular vesicles (EVs) from endothelial cells. Our studies will provide mechanistic insights into how factor VIIa generates these vesicles and influences hemostasis, inflammation, and barrier integrity directly or by communicating with other cell types through cargo delivery from EVs to recipient cells. The knowledge gained from our proposed studies will have enormous significance in improving current therapeutic options for treating bleeding and inflammatory disorders and opening new therapeutic modalities.

PI_NAMEs: LELLA, VIJAYA MOHAN RAO (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: activated Protein C;activated protein C receptor;Address;Affect;Anti-Inflammatory Agents;Anticoagulants;Behavior;Binding;Biogenesis;Biological Models;Blood;Blood Coagulation Disorders;Blood Coagulation Factor;Blood Vessels;Cell Physiology;cell type;Cells;Cerebral hemisphere hemorrhage;Clinical;Clinical Treatment;clinically relevant;Coagulation Process;cofactor;Communication;cost effective;Data;design;Disease;Distant;Drug Delivery Systems;Endothelial Cells;Endothelium;Exhibits;extracellular vesicles;F8 gene;Factor VIIa;Functional disorder;functional gain;Hemophilia A;Hemophilic Arthritis;Hemorrhage;Hemostatic Agents;Hemostatic function;improved;In Vitro;in vivo;Inflammation;Inflammatory;Infusion procedures;inhibitor;insight;intercellular communication;Knowledge;Laboratories;Lead;Liver diseases;Mediating;Mediator;Modality;monocyte;mouse model;novel;novel therapeutic intervention;novel therapeutics;off-label use;Operative Surgical Procedures;PAR-1 Receptor;Pathologic Processes;Pathway interactions;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Phenotype;Phosphatidylserines;Phospholipids;Physiological Processes;Plasma;Play;Process;Property;protective effect;Protein C;Proteinase-Activated Receptors;Publications;Published Comment;Publishing;receptor;Recombinants;release factor;Research;response;Role;Sampling;Series;Signal Induction;Signal Transduction;Therapeutic;Thromboplastin;Transgenic Mice;uptake;Vesicle

PROJECT_TITLE: Factor VIIa-released extracellular vesicles: Their role in hemostasis and beyond

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: FLUSHING

ORG_DEPT: CHEMISTRY

ORG_NAME: QUEENS COLLEGE

ORG_STATE: NY

PHR: Project Narrative  The peptide synthesizer has been widely used to build up chemical libraries of peptides, biosensors, and small enzymes for the discovery of therapeutic candidates for human diseases. Due to the system’s automation and microwave heating capabilities, the instrument can synthesize peptides in an efficient, cost-effective, and nature-friendly way. This is highly beneficial for biomedical research in a resource-limited institution. The straightforward operation of the system enables students to learn basic laboratory skills of peptide synthesis and its applications in drug design and discovery.

PI_NAMEs: CHOI, JUN-YONG  (contact)

PROGRAM_OFFICER_NAME: BECKETT, DOROTHY

PROJECT_TERMS: Amides;Amino Acids;Biological;Biology;Biomedical Research;Biosensor;Cells;Chemical Agents;Complex;Computer software;cost effective;Coupling;Education;Educational process of instructing;Engineering;Enzymes;equipment acquisition;experimental study;Freedom;Friends;Heating;high school;Hour;human disease;Hybrids;improved;Institution;instrument;instrumentation;Laboratories;Learning;Methods;microwave electromagnetic radiation;novel;Peptide Synthesis;Peptides;peptidomimetics;Phosphotransferases;Plant Resins;Productivity;Protocols documentation;Reaction;Reaction Time;Research;Research Personnel;Research Project Grants;Resources;S phase;sensor;skills;small molecule libraries;Solid;Solvents;Students;Syringes;System;Temperature;Therapeutic;therapeutic candidate;Time;Training;undergraduate student

PROJECT_TITLE: Microwave Peptide Synthesizer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (30)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: UROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Metabolic heterogeneity drives potential therapeutic vulnerabilities and may predict clinical outcomes. In this proposal, we focus on metabolic liabilities in KRAS-driven, LKB1 mutant non-small cell lung cancer (KL NSCLC) which is different from KL pancreatic tumors. This work will provide insights for tissue-specific metabolic interventions to suppress cancer progression more effectively.

PI_NAMEs: KIM, JIYEON  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Affect;Algorithms;amino acid metabolism;Antineoplastic Agents;Antioxidants;ATAC-seq;Bioinformatics;Biological Assay;Biology;BRAF gene;Branched-Chain Amino Acids;cancer cell;Cancer Patient;cancer subtypes;Carbon;Cell Death;Cell Lineage;Cells;Chemicals;chemotherapy;Clinical;clinically relevant;Collaborations;Data;Dependence;Disease;DNA Methylation;driver mutation;Drug Targeting;Enzymes;Epidermal Growth Factor Receptor;Equilibrium;Event;Exhibits;experience;experimental study;Fatty Acids;Frequencies;G6PD gene;Gene Expression;Gene Mutation;Genetic;Glucose;Glutamine;Glycine;Glycine Hydroxymethyltransferase;Goals;Growth;Heterogeneity;Homeostasis;Human;Hyperactivity;in vivo;in vivo Model;insight;Intervention;Kininogenase;KRAS oncogenesis;KRAS2 gene;lung cancer cell;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Measures;Mediating;Metabolic;metabolic abnormality assessment;Metabolism;metabolome;methyl group;Mitochondria;Molecular;Molecular Biology;molecular subtypes;mouse model;Mus;mutant;Mutation;NADP;new therapeutic target;Nitrogen;Non-Small-Cell Lung Carcinoma;novel;Oncogenes;Oncogenic;Operative Surgical Procedures;Outcome;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Pancreas;pancreatic cancer model;pancreatic neoplasm;Pathway interactions;Patient Selection;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphotransferases;Positioning Attribute;Pre-Clinical Model;precision medicine;predict clinical outcome;Predisposition;Production;Regulation;Reporting;Resected;Role;Sampling;Serine;Signal Transduction;Sodium Chloride;Source;STK11 gene;Stratification;subcutaneous;Survival Rate;targeted treatment;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissues;Transgenic Mice;translational potential;treatment responders;treatment strategy;tumor;tumor growth;tumor metabolism;tumor progression;Tumor Suppressor Proteins;Up-Regulation;uptake;Work

PROJECT_TITLE: Uncovering Oncogenotype-specific Vulnerabilities in Lung cancer

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Nonalcoholic Fatty Liver Disease (NAFLD) progresses in a significant subset of patients to NASH with fibrosis and liver cancer, for reasons that are almost completely unknown and for which there is no proven treatment. We will examine how impaired VLDL secretion modifies key pathways for fibrosis and cancer development in both genetically modified mouse models and a subset of NAFLD/NASH patients. Our mouse models and studies in patients will allow us to identify novel targets to prevent fibrosis and liver cancer in a representative subset of NAFLD/NASH patients with impaired VLDL secretion.

PI_NAMEs: DAVIDSON, NICHOLAS O. (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acceleration;Address;Biological Markers;Cell Line;Cells;Chylomicrons;Cirrhosis;Compensation;CRISPR/Cas technology;Critical Pathways;Data;Development;Disease;druggable target;epidemic response;Etiology;Exhibits;Fatty Acids;Fatty Liver;Fibrosis;Gene Expression Profiling;Gene Modified;Genes;Genetic;Genetic Models;genotoxicity;Genotype;Germ Lines;Goals;Golgi Apparatus;Health;Hepatic;Hepatocyte;HepG2;Homeostasis;Human;human induced pluripotent stem cells;Impairment;induced pluripotent stem cell;Inflammatory;Injury;insight;Insulin Resistance;Intestines;kindred;Knock-in;Knock-out;Knockout Mice;Knowledge;lipid biosynthesis;Lipids;Liver;liver injury;loss of function;Malignant neoplasm of liver;Malignant Neoplasms;Mediator;Metabolic;metabolic phenotype;metabolomics;microsomal triglyceride transfer protein;Modeling;mortality;mouse model;Mus;Mutation;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Obesity;Pathway interactions;patient subsets;Patients;personalized approach;Phenocopy;Phenotype;Pre-Clinical Model;Predisposition;prevent;Prevention;Prevention strategy;Primary carcinoma of the liver cells;Role;Serum;Signal Pathway;Signal Transduction;Steatohepatitis;Stress;Therapeutic;Thinness;Tissues;trafficking;transcriptomics;Tumor Burden;tumor progression;tumorigenesis;tumorigenic;Variant;Very low density lipoprotein

PROJECT_TITLE: Impaired VLDL secretion in progression of NAFLD and NASH in mice and humans

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: OMAHA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Narrative Children prenatally exposed to alcohol have impaired auditory processing. Here, we will study the cellular mechanisms of auditory processing in a mouse model of maternal voluntary alcohol consumption throughout gestation and test the hypothesis that prenatal alcohol exposure alters auditory processing as a result of changes in perineuronal nets, altered maturation of parvalbumin interneurons, and changes in inhibition in the auditory system. The role of perineuronal nets integrity for normal parvalbumin neuron function, GABAergic synaptic transmission, and auditory processing will be examined by manipulating perineuronal nets in vivo.

PI_NAMEs: RAGUNATHAN, PADMASHRI  (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Achievement;Acoustic Nerve;Acoustics;Affect;Alcohol consumption;alcohol consumption during pregnancy;alcohol exposure;Anatomy;Animal Model;Auditory;Auditory area;Auditory Brainstem Responses;auditory pathway;auditory processing;Auditory system;Behavior;Brain Stem;Cell Physiology;Cells;Child;Cochlea;Cognitive deficits;Complex;Data;Development;Digestion;disability;Disease;Electrophysiology (science);Equilibrium;Exhibits;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;FOS gene;Functional disorder;gamma-Aminobutyric Acid;Goals;hearing impairment;Impairment;in vivo;in vivo calcium imaging;Individual;Inferior Colliculus;Inhibition of Matrix Metalloproteinases Pathway;insight;Interneuron function;Interneurons;Intervention;Knowledge;Life;Link;Measures;Mediating;Midbrain structure;Modeling;mouse model;Mus;neural;neuromechanism;Neuronal Plasticity;Neurons;offspring;otoacoustic emission;Outer Hair Cells;Parvalbumins;Peripheral;pharmacologic;Population;Pregnancy;prepulse inhibition;Research;Rodent;Role;Secondary Prevention;Sensory;sensory cortex;signal processing;Signal Transduction;Slice;sound;Startle Reaction;Structure;synaptic inhibition;Synaptic Transmission;Testing

PROJECT_TITLE: Cellular mechanisms of auditory processing deficits in a mouse model of Fetal Alcohol Spectrum Disorders

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: Minorities and disadvantaged populations are significantly underrepresented in genomics and biomedical research professions. The AGTC (Attaining Genomics Talent Cloud) through Undergraduate Research Experience Program, a joint proposal from Tennessee State University and Vanderbilt University Medical Center, seeks to address this underrepresentation through excellent didactic training, mentoring and near-peer mentoring by Tennessee State University and Vanderbilt faculty and students, and a rich research experience at Vanderbilt. The outcome of project is that trainees will persist in genomics and biomedical research and contribute to workforce diversity.

PI_NAMEs: COONEY, KIMBERLY ANN;SARASWATI, SARIKA ;STALLINGS, SARAH C.;WANG, XIAOFEI  (contact)

PROGRAM_OFFICER_NAME: TINGLE, SHARNA R

PROJECT_TERMS: Abbreviations;Academic Medical Centers;Acceleration;Address;Admission activity;Area;Awareness;Biomedical Research;career;cohort;Collaborations;Communities;Competence;design;Development Plans;Disparity;Disparity population;Diverse Workforce;Doctor of Philosophy;Education;education research;Educational Curriculum;Educational process of instructing;Ensure;Environment;Ethics;ethnic minority population;experience;Face;Faculty;Funding;Genetic;Genome;genome sciences;genomic data;Genomics;Geography;Goals;graduate school;Health;health disparity;health equity promotion;higher education;Historically Black Colleges and Universities;Immersion;improved;Individual;Infrastructure;innovation;Inosine Diphosphate;Institution;interest;Joints;knowledge base;Lead;Legal;Light;Malignant Neoplasms;matriculation;Medical;Medicine;Mentors;Minority;Minority Groups;minority undergraduate;Minority-Serving Institution;Outcome;Participant;peer coaching;prevent;Productivity;Program Effectiveness;programs;Qualifying;recruit;Research;Research Activity;research faculty;Research Personnel;Resource Sharing;Resources;response;role model;Science;science education;Self Efficacy;skills;social;Students;success;support network;symposium;Talents;Tennessee;Training;Travel;undergraduate education;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;Universities

PROJECT_TITLE: AGTC: Attaining Genomics Talent Cloud through Undergraduate Research Education

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-M (J2)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Dystonia;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative: White matter tracts connect nodes in a brain circuit. This project will develop and test a non-invasive, targeted approach to deliver gene therapy to white matter tracts & white matter hubs to treat neurologic and psychiatric diseases. The broader goal of the project is to improve the treatment of brain circuit diseases using these tools.

PI_NAMEs: SHAH, BHAVYA RAMESH (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 3-Dimensional;Advanced Development;Aging;Alzheimer's disease model;Anatomy;Animal Model;anterograde transport;Behavioral Assay;Biodistribution;Biological Assay;Blood - brain barrier anatomy;Brain;brain based;brain cell;Brain Diseases;Brain Mapping;Brain region;brain tissue;Bypass;Capsid;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Clinical;conditional knockout;Corpus striatum structure;Data;Disease;Distal;Dose;Dystonia;empowerment;Engineering;Exhibits;Focused Ultrasound;Functional disorder;Gases;Gene Delivery;Gene Expression;gene product;gene therapy;gene-targeted therapy;Goals;Hippocampus;Histopathology;Human;Immune response;improved;Injections;Injury;Internal Capsule;Intrathecal Injections;Knock-in Mouse;Knockout Mice;Laboratory Study;Light;Lipids;Mediating;Mental disorders;Methods;Microbubbles;Microscopy;Modeling;Motor;motor disorder;mouse model;Mus;mutant;Nerve Degeneration;Nervous System Disorder;neural circuit;Neurons;Neurosciences Research;novel;overexpression;Pathology;Phenotype;pressure;promoter;Proteins;proteotoxicity;Reporter;retrograde transport;Safety;Serotyping;Site;Specificity;Synapsins;targeted delivery;tau expression;tau Proteins;Testing;Therapeutic;tool;TorsinB;Transgenic Organisms;vector;Viral;Viral Genes;Viral Vector;Visualization;Western Blotting;white matter

PROJECT_TITLE: Improving Focused Ultrasound Mediated Viral Gene Therapy Delivery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-M (91)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: SAN ANTONIO

ORG_NAME: ST. MARY'S UNIVERSITY

PHR: Project Narrative The proposed Incucyte SX5 Live-Cell Analysis System at St. Mary's University not only addresses the limitations of traditional fluorescent microscopes but also provides students with access to exciting new technology. By utilizing this state-of-the-art instrument for high-throughput cell-based assays, students will have the opportunity to engage with cutting-edge techniques and technologies, igniting their interest and passion for science careers. This invaluable experience will broaden their perspective on scientific research, inspiring them to pursue a future dedicated to scientific exploration and innovation.

PI_NAMEs: SHACKLEFORD, TERRY JO (contact)

PROJECT_TERMS: Algorithms;Apoptosis;Applications Grants;Area;Automobile Driving;Biological;Biological Assay;Biology;Biomedical Research;Calibration;Cell Cycle;Cells;cellular imaging;Chemistry;Collaborations;Communities;Computer software;Consumption;cytotoxicity;Data;data management;Data Storage and Retrieval;Dedications;Educational process of instructing;empowerment;Engineering;Environmental Science;experimental study;Faculty;Fluorescence;fluorescence microscope;Funding;Future;Generations;Graph;Image;imager;imaging system;Incubated;Incubators;instrument;laboratory curriculum;live cell imaging;Methods;Microscope;Mission;Molecular;Preparation;Publications;Research;Research Personnel;Resources;Running;Sampling;Shapes;Slide;STEM field;Students;System;Systems Analysis;Techniques;Technology;Time;tissue culture;tool;United States National Institutes of Health;Universities;user friendly software;Visual

PROJECT_TITLE: Incucyte SX5 Live-Cell Analysis System


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Duchenne/ Becker Muscular Dystrophy;Heart Disease;Muscular Dystrophy;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

PHR: Muscular dystrophy is a genetic disorder that develops progressive wasting of skeletal muscle and heart failure. Metabolic phenotypes precede muscle wasting and have been targeted for mechanistic understanding and development of therapeutic intervention, yet their roles in pathogenesis of muscular dystrophy are still unclear. In this study, we will develop non-invasive imaging biomarkers that describe two major metabolic phenotypes of muscular dystrophy: inflammation and mitochondrial dysfunction.

PI_NAMEs: MAMMEN, PRADEEP P.A.;PARK, JAE MO  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Adolescent;Adult;Age;Alanine;Alanine Transaminase;Appearance;Becker Muscular Dystrophy;Bicarbonates;Biochemical Reaction;Biological;Biological Markers;Blood specimen;Body mass index;Carbon;Cardiac;Characteristics;Citric Acid Cycle;Clinical;clinical translation;Coronary;Data;Development;Disease Progression;Duchenne muscular dystrophy;Dystrophin;dystrophinopathy;early detection biomarkers;Echocardiography;Exercise;Genes;Genetic Diseases;Glucose;Glycolysis;Goals;Heart;Heart failure;Hour;Image;imaging biomarker;imaging modality;in vivo;in vivo imaging;Inflammation;inflammatory marker;Injections;Intravenous Bolus;Investigation;Ionizing radiation;Lactate Dehydrogenase;Link;Magnetic Resonance Imaging;Measurement;Measures;Metabolic;metabolic imaging;Metabolic Marker;metabolic phenotype;Mitochondria;mitochondrial dysfunction;Modeling;Monitor;Motion;Muscle;Muscle Cells;Muscle Development;muscle metabolism;Muscular Atrophy;Muscular Dystrophies;Muscular dystrophy cardiomyopathy;Mutation;Myocardial;Myocarditis;Myocardium;Myopathy;Neuromuscular Diseases;non-invasive imaging;Outcomes Research;Pathogenesis;Patients;pediatric patients;Physiological;Play;Positioning Attribute;predict clinical outcome;Production;Protocols documentation;Pyruvate;pyruvate dehydrogenase;recruit;Respiration;Rest;Risk;Role;Scanning;Series;Serum;Severities;Skeletal Muscle;skeletal muscle metabolism;skeletal muscle wasting;stable isotope;Techniques;Technology;therapeutic development;Therapeutic Intervention;Tissues;tool;treatment response;Troponin T;Ventricular Ejection Fractions

PROJECT_TITLE: Development of early metabolic imaging biomarkers for muscular dystrophy and cardiomyopathy in patients

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Natural Products;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE With no new effective treatment options, relapsed, resistant triple-negative breast cancer (TNBC) has poor long- term outcomes. TNBC cells’ notable survival dependency on high glucose-6-phosphate dehydrogenase and thioredoxin reductase 1 functions, elevated NADPH and GSH levels, and aberrantly-active signal transducer and activator of transcription 3 as an adaptation mechanism makes then therapeutically vulnerable to two inhibitor groups, R001, R002, and H182, H333 that we have develop. We propose to use these compounds to study TNBC and define the structural and mechanistic bases of the antitumor activities of these compounds.

PI_NAMEs: TURKSON, JAMES K (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: 4T1;Affect;analog;antitumor effect;Antitumor Response;azetidine;base;Binding;Binding Sites;biological adaptation to stress;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Treatment;cancer survival;Cell Cycle;Cell Cycle Arrest;Cell Death;Cell Line;Cell Survival;Cells;chemotherapy;Citric Acid Cycle;Clinical Trials;Combined Modality Therapy;commercialization;Consumption;Data;Dependence;Development;DNA Damage;effective therapy;endoplasmic reticulum stress;Event;Gene Expression;Gene Expression Regulation;Genes;Glucosephosphate Dehydrogenase;Glycolysis;Growth;Health Promotion;Immune;improved;In complete remission;In Vitro;in vivo;in vivo Model;Inbred BALB C Mice;Inflammation;inhibitor;inorganic phosphate;insight;knock-down;Knowledge;Lead;malic enzyme;Metabolic;Modeling;Molecular;Mus;NADP;Natural Products;Normal Cell;novel;Outcome;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pattern;Pentosephosphate Pathway;Personal Satisfaction;Plants;Predisposition;Proteomics;Reactive Oxygen Species;Recurrent disease;Relapse;Resistance;response;Role;senescence;side effect;Signal Transduction;Site;small molecule;small molecule inhibitor;smoking cessation;STAT3 gene;Stat3 protein;Tea;Tetrahydrofolates;Therapeutic;therapeutically effective;thioredoxin reductase 1;transcriptome sequencing;treatment response;trend;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;Tumor Tissue;X-Ray Crystallography;Xenograft procedure

PROJECT_TITLE: Mechanistic studies of hirsutinolides and azetidine-based small molecule inhibitors of STAT3

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: ROCHESTER

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: This proposed research aims to use a mixed-method approach to examine the impact of the CMS’ telemedicine policy on assisted living community (AL) residents with ADRD and how it varies by AL-, market- and state regulatory factors and across different pandemic stages (including the pre, during and post-pandemic period). We will employ 2018- 2024 national data to examine the utilization of different types of outpatient services (both telemedicine and total visits) and other relevant health services (e.g., nursing home placement); and will collect primary data to explore factors that may influence telemedicine use in ALs. This proposed research will provide information on potential benefits/challenges to telemedicine use among AL residents with ADRD, and offer valuable and timely insights for the CMS’ telemedicine policy decisions.

PI_NAMEs: CAI, SHUBING  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accounting;Address;Affect;Alzheimer's disease related dementia;Area;Assisted Living Facilities;care providers;Caring;Communities;community living;community organizations;Complex;COVID-19 pandemic;Data;Disparity;economic disparity;Emergency department visit;Event;experience;Family Characteristics;Goals;Health;health care service utilization;Health Personnel;health service use;Health Services;Health Services Accessibility;Home;Hospitalization;Impaired cognition;Improve Access;informant;Infrastructure;innovation;insight;Internet;Interview;Life Style;Marketing;Medical;medical specialties;Medicare/Medicaid;Mental Health;Mental Health Services;Methods;Nursing Homes;older adult;outpatient programs;Outpatients;pandemic disease;pandemic impact;Persons;physical impairment;Play;Policies;Population;post-pandemic;Primary Care;Quality of Care;recruit;Regulation;Research;Resources;Role;Services;Site;socioeconomics;Specificity;Speed;Structure;Telemedicine;Telephone Interviews;Training;Transportation;United States Centers for Medicare and Medicaid Services;Variant;Visit;Wages

PROJECT_TITLE: Telemedicine Use Among Assisted Living Residents with ADRD: Assisted Living, Market, and State Regulatory Factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-P (91)]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Narrative The proposed project aims to define the molecular mechanisms that regulate the Okazaki fragment maturation (OFM) pathway, an important part of DNA replication that if disrupted results in DNA mutations, cancer, and resistance to cancer therapy. We will characterize the dynamic interactions of key proteins involved in this complex pathway, including DNA polymerases, nucleases, ligases, and other accessory proteins. A better understanding of these mechanisms may provide a strategy to guide the development of improved cancer therapeutic regimens.

PI_NAMEs: SHEN, BINGHUI  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Arginine;Binding;Biological Assay;cancer cell;Cancer Etiology;cancer predisposition;cancer therapy;Cell Death;cell type;Cells;Chromatin;Complex;Defect;demethylation;Development;Dissociation;DNA;DNA biosynthesis;DNA Double Strand Break;DNA Ligases;DNA replication fork;DNA Sequence Alteration;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;Drops;Drug resistance;Ensure;Enzymes;Evolution;Excision;Exhibits;Gene Mutation;Genomic Instability;Goals;Histones;Human;improved;inhibitor;insight;knock-down;Knowledge;Ligase;Ligation;Lysine;Malignant Neoplasms;Mediating;Molecular;Molecular Chaperones;Mutagenesis;Mutation;Nuclear Extract;nuclease;Nucleosomes;Okazaki fragments;Pathologic;Pathway interactions;patient population;Phosphorylation;Physiology;Poly(ADP-ribose) Polymerases;Polymerase;Post-Translational Protein Processing;prevent;Process;Proteins;recruit;Regimen;Regulation;repaired;Resistance;Resistance development;response;RNA;RNA primers;Role;RTH-1 Nuclease;S phase;Scaffolding Protein;Site;Stress;Therapeutic;therapeutically effective;Time;tumorigenesis;Workplace

PROJECT_TITLE: FEN1-mediated Okazaki fragment maturation and its deficiency in cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention;Serious Mental Illness;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative Approximately 13.8 million people in the U.S. are projected to have Alzheimer's disease (AD) by 2060, making it one of the most important public health challenges of our time. We have a rare opportunity to investigate how memory decline, AD pathology, and neurovascular dysfunction with age are preceded and accelerated by emotion dysregulation/depression, particularly in women, in part, as a consequence of immune system dysregulation that begins in fetal development. Understanding this could provide insights into development of early interventions to prevent AD or attenuate disease burden.

PI_NAMEs: GOLDSTEIN, JILL M (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Acceleration;Adult;Adverse effects;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amygdaloid structure;Amyloid;amyloid imaging;Anterior;Area;Arousal;Attenuated;Blood;Blood Vessels;blood-based biomarker;Brain region;burden of illness;Circulation;Cognitive;cohort;Coupled;cytokine;Dementia;Deposition;Development;disability;Early Intervention;emotion dysregulation;emotion regulation;Emotions;entorhinal cortex;Exhibits;Exposure to;Family Study;fetal;Fetal Development;Functional disorder;Functional Magnetic Resonance Imaging;Gene Expression;Genomic approach;Hippocampus;Hormones;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Image;Image Analysis;Immune;Immune system;Immunity;Impaired cognition;Inflammatory;inflammatory marker;innovation;insight;Interleukin-1 beta;Interleukin-6;life span;Link;locus ceruleus structure;Major Depressive Disorder;Measures;Memory;Memory Loss;men;Mental Depression;middle age;mild cognitive impairment;Molecular;Moods;Multimodal Imaging;negative affect;Negative Valence;Nerve Degeneration;Neuroimmune;neurovascular;neurovascular coupling;New England;noradrenergic;Norepinephrine;novel;offspring;Outcome;Oxygen;Pathology;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Physiological;Physiology;Positron-Emission Tomography;pre-clinical;Prefrontal Cortex;prenatal;prevent;prospective;Public Health;receptor;recruit;Regulation;response;Risk;Sampling;sex;Sex Differences;sexual dimorphism;Signal Transduction;Site;steroid hormone;Stimulus;Stress;Structure;symptomatology;Symptoms;System;tau Proteins;Testing;Third Pregnancy Trimester;Time;TNF gene;transcriptomics;Woman

PROJECT_TITLE: Aging of Emotion Circuitry and Risk for Alzheimer's disease: Impact of Sex, Immunity, and Fetal Origins

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: In this proposal, we hypothesize that the inhibition of PAD4 using PAD4 antagonistic peptide (PAP) will suppress the formation of neutrophil extracellular trap (NET), and NET-induced thrombosis, and enhance neovascularization and functional recovery after TBI. We will validate the effect of PAP with PAD4 KO mice (PAD4-/-) and CRISPR/Cas9 mediated PAD4 gene deletion in human brain microvascular endothelial cells (hBMVEC) and mice. We will use cohorts of behavioral tests that include cognitive, sensory-motor functions, and psychological stress to validate the effect of PAP in functional recovery in wild-type (WT) and PAD4-/- mice following TBI.

PI_NAMEs: MUNEER, MOHAMMED ABDUL (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Adhesions;Animals;Arginine deiminase;Astrocytes;Attenuated;Behavior;behavior test;Bioinformatics;Biological;Blood brain barrier dysfunction;Blood Cells;Brain;brain cell;brain endothelial cell;Brain Injuries;Breeding;Cells;Chromatin;Coculture Techniques;Cognitive;cohort;conditional knockout;CRISPR therapeutics;CRISPR/Cas technology;Data;design;DNA Structure;Elements;Endothelial Cells;Enzymes;Event;extracellular;Feedback;Fiber;fluid percussion injury;Gene Deletion;Goals;Histones;Human;Immune;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;injured;Injury;Internet;Investigation;Knockout Mice;Knowledge;leukocyte activation;Leukocytes;Mediating;Memory;Microglia;migration;Molecular;Motor;motor deficit;mouse model;Mus;neovascularization;neuroinflammation;Neurons;neurovascular;neurovascular injury;neutrophil;novel;Nuclear;Outcome;Pathogenesis;peptide drug;Peptides;pharmacologic;Psychological Stress;Recovery of Function;Regulation;Research;Role;Sensorimotor functions;Sensory;Stains;Stretching;Testing;Therapeutic;Therapeutic Agents;Therapeutic Studies;Thrombosis;Tissues;Traumatic Brain Injury;Traumatic Brain Injury recovery;Treatment Efficacy

PROJECT_TITLE: Neutrophil extracellular traps and associated pathogenesis in TBI: a novel peptide therapeutic strategy.

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Immunotherapy;Neurodegenerative;Neurosciences;Peripheral Neuropathy

PHR: Project Narrative: Humoral immunity is critical to the pathogenesis of chronic inflammatory demyelinating polyneuropathy (CIDP) but many aspects of disease pathomechanism remain unknown. In this study, we will examine the pathomechanism of nodal/paranodal antibodies at the monoclonal level. We will also leverage the high throughput antigen discovery platforms for discovering and validating new antigen targets in CIDP.

PI_NAMEs: ROY, BHASKAR  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Affect;Affinity;Animal Model;Antibodies;Antibody Affinity;antibody-dependent cell cytotoxicity;Antigen Targeting;Antigens;arm;Autoantibodies;Autoantibody binding;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;autoreactive B cell;axon injury;B cell therapy;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Binding;Biological Assay;Biopsy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Death;Cells;Chronic Inflammatory Demyelinating Polyneuropathy;Classification;clinical phenotype;Clone Cells;Complement;Complement Activation;contactin;Defect;Demyelinations;Deposition;Disease;disease model;disease phenotype;disorder control;Distal;Economic Burden;extracellular;Functional disorder;Gene Expression;Glucocorticoids;Helper-Inducer T-Lymphocyte;Human;human monoclonal antibodies;Humoral Immunities;IgG4;IgG4-related disease;Immune response;Immunoglobulin Somatic Hypermutation;Immunoglobulins;immunopathology;improved;Individual;Infiltration;inhibitor;insight;Intravenous;Length;Macrophage;Mediating;molecular pathology;Muscle Weakness;Myelin;neonatal Fc receptor;Nerve;Neural Conduction;neurofascin;Neuromuscular Diseases;new therapeutic target;Nodal;nodal protein;novel therapeutics;Pathogenesis;Pathogenicity;Pathology;Patient Care;Patients;peripheral blood;Peripheral Nerves;Peripheral Nervous System;Phage ImmunoPrecipitation Sequencing;Phagocytosis;Phenotype;Plasmapheresis;Population;Proteins;Recombinants;repaired;Role;Schwann Cells;Sensory;sequencing platform;Serum;socioeconomics;Specificity;Stable Disease;subcutaneous;sural nerve;Symptoms;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Th1 Cells;Therapeutic;tool;treatment response

PROJECT_TITLE: In-depth characterization of B-cell dysfunction in chronic inflammatory demyelinating polyneuropathy

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;Health Services;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE An estimated 2.4 million CT scans are performed annually to evaluate for pulmonary embolism in Emergency Departments in the United States. Approximately one-third of all studies are avoidable, with each scan resulting in unnecessary exposure to radiation and increasing risk for iatrogenic lung cancer and heart disease. This study evaluates a simple solution embedded within the electronic health record designed to nudge clinicians into using a validated clinical prediction rule to assess pulmonary embolism risk before CT scan, which can safely reduce testing by 25%.

PI_NAMEs: RICHARDSON, SAFIYA  (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: Accident and Emergency department;Address;Adoption;American;Architecture;Asian population;Behavior assessment;Behavioral;behavioral economics;budget impact;cardiovascular disorder risk;Caring;Cessation of life;Chest;Clinical;clinical decision support;Clinical effectiveness;clinical efficacy;clinical predictors;cluster randomized design;cognitive load;college;Communication;community setting;Consent;cost;cost effectiveness;Decision Making;design;Development;Diagnosis;Diagnostic tests;Electronic Health Record;Emergency Medicine;Enrollment;Ethnic Origin;evidence base;Evidence based practice;Exposure to;Fast Healthcare Interoperability Resources;Fright;Geography;Goals;Guidelines;Health;Health system;Heart Diseases;high risk;Hispanic Populations;Hybrids;Iatrogenesis;Image;implementation intervention;implementation science;implementation strategy;improved;Incidental Findings;Inequity;innovation;innovative technologies;insight;Interview;Malignant neoplasm of lung;Malignant Neoplasms;Methods;novel strategies;Organ Donations;Outcome;patient population;Patients;peer;Physicians;pilot test;Positive Reinforcements;predictive tools;prevent;primary outcome;Probability;Proctor framework;Professional Organizations;Protocols documentation;Provider;provider adoption;Pulmonary Embolism;Race;Radiation;Randomized;Recommendation;Reporting;Risk;risk prediction;risk stratification;Scanning;Site;Structure;Suggestion;support tools;Surveys;Technology;Testing;theories;Time;tool;treatment as usual;United States;web platform;Work;X-Ray Computed Tomography

PROJECT_TITLE: Nudging Provider Adoption of Clinical Decision Support: Implementation of an EHR-Agnostic Pulmonary Embolism Risk Prediction Tool

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE The focus of our research proposal is to dissect and uncover a role for the dorsal hippocampus and its excitatory inputs to the nucleus accumbens. Findings generated from the proposed research will provide critical insight on the circuit-based mechanisms underlying opioid seeking and relapse, transforming our understanding of opioid misuse and abuse.

PI_NAMEs: MORON-CONCEPCION, JOSE A (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;Aversive Stimulus;Behavior;Behavioral Paradigm;Biological Assay;Brain;Calcium;cell type;Cells;craving;Cues;Data;Development;Dorsal;drug craving;drug relapse;drug seeking behavior;Dynorphins;Electrophysiology (science);Emotional;Enkephalins;excitatory neuron;Exhibits;Exposure to;fentanyl seeking;fentanyl self-administration;Fiber;Genetic;Glutamates;Goals;Hippocampus;in vivo;insight;Learning;Maintenance;Measures;Memory;Modeling;Molecular Target;Morphine;Mus;N-Methylaspartate;Nature;Neuronal Plasticity;Neurons;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid abuse;opioid exposure;opioid misuse;opioid use;opioid use disorder;optogenetics;Peptides;Pharmaceutical Preparations;Photometry;Play;Population;preference;prevent;Property;Psychological reinforcement;Relapse;Reporting;Research;Research Proposals;reward circuitry;Rewards;Role;Self Administration;Self Stimulation;Signal Transduction;Slice;Stimulus;Structure;Synapses;Technology;Testing;Time;translational potential;transmission process;Ventral Tegmental Area;wireless

PROJECT_TITLE: Dissecting the role of dorsal hippocampus to nucleus accumbens circuits in opioid seeking behavior

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Pediatric;Physical Activity;Prevention

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Physical inactivity is well known for its negative influences on not only physical health but also cognitive functioning during child development. Understanding effective exercise-based strategies for promoting childhood physical activity as well as enhancing cognition and brain function is of great importance for maximizing children's academic potential, school performance, and overall health as they develop through the human lifespan. For the first time, our proposed study will begin empirically investigating the effectiveness of a hybrid mindfulness high-intensity interval training for generating short-term and long-term benefits to executive function in children.

PI_NAMEs: KAO, SHIH-CHUN  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 12 year old;Academic achievement;Academic support;active control;Acute;Affective;Arousal;Attention;Behavioral;Brain;Breathing;Buffers;Categories;Child;Child Development;Childhood;Chronic;Cognition;Cognitive;cognitive benefits;cognitive development;cognitive function;Conflict (Psychology);conflict resolution;Control Groups;Cross-Over Trials;Detection;Development;Dose;Educational Intervention;Effectiveness;effectiveness testing;Event;executive function;Exercise;exercise intervention;exercise program;experience;flexibility;Foundations;Future;gain of function;Goals;Health;Health Benefit;Human;Hybrids;Impairment;improved;Informal Social Control;Interval training;Intervention;Laboratories;life span;Measures;Mental Health;mental representation;Mind-Body Intervention;mindfulness;Modernization;Movement;neural;novel;Outcome;Performance;Physical activity;physical conditioning;Physical Fitness;physical inactivity;prevent;Problem Solving;programs;Psyche structure;Public Health;Randomized, Controlled Trials;Recovery;Regulation;Research;response;Schools;sedentary;sedentary activity;Self Perception;sound;Speed;Stimulus;Strenuous Exercise;Techniques;Testing;theories;Time;Update;Weight

PROJECT_TITLE: Supporting high-intensity interval training with mindfulness for enhancing childhood executive function

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: The constriction of brain capillaries is well documented in dementia and leads to cerebral blood flow impairment, yet researchers lack approaches to mimic these brain capillary constrictions for studies in animal models. This project will create novel mouse models that allows chemical-mediated control of brain capillary perfusion that is adjustable in its severity, easy-to-use, and complementary to other existing models of Alzheimer’s disease and Vascular Contributions to Cognitive Impairment and Dementia.

PI_NAMEs: SHIH, ANDY Y (contact);ZHAO, ZHEN

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: abeta deposition;Acceleration;Acute;Address;Adult;age related;Agonist;Alleles;Alzheimer's Disease;Alzheimer's disease model;Amyloid;Amyloid beta-Protein;Amyloid deposition;Animal Model;Bilateral;Biological;Blood capillaries;Blood flow;Blood Vessels;blood-brain barrier function;brain control;brain magnetic resonance imaging;brain pericytes;Breeding;Carotid Stenosis;Cells;Central Nervous System;Cephalic;cerebral capillary;cerebral hypoperfusion;cerebral microinfarct;Cerebrovascular Circulation;Chemicals;Chronic;Clinical;cognitive testing;Collaborations;constriction;Cre lox recombination system;CRISPR/Cas technology;Crossbreeding;Data;Dementia;Designer Drugs;designer receptors exclusively activated by designer drugs;Diameter;disease model;Dose;drinking water;Engineering;Exhibits;Fibroblasts;Functional disorder;G-Protein-Coupled Receptors;Genes;Genetic;Genetic Markers;Genetic Models;Genetic Recombination;gray matter;Histology;Homeostasis;hypoperfusion;Hypoxia;Image;Impaired cognition;Impairment;improved;in vivo;Internal Ribosome Entry Site;Knock-in;Knock-in Mouse;Laboratories;Ligands;LoxP-flanked allele;Maps;Mediating;Metabolic;Modeling;mouse model;Mus;neuroinflammation;novel;old mice;overexpression;Oxygen;Pathology;Perfusion;Pericytes;Peripheral;Phase;pre-clinical;receptor;Relaxation;Reporter;Research;Research Personnel;Severities;Smooth Muscle Myocytes;Specificity;Tamoxifen;Technology;Testing;The Jackson Laboratory;therapeutic target;Tissues;tool;transcriptomics;Transgenic Model;two-photon;vascular cognitive impairment and dementia;white matter

PROJECT_TITLE: Chemogenetic Mouse Models for Cerebral Hypoperfusion and VCID

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-M (17)]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

PHR: PROJECT NARRATIVE This project builds on our recent publication and new discovery that GPR92 and its agonist farnesyl pyrophosphate (FPP) play an important role in high fat diet-induced islet inflammation. The current proposal is designed to study the intercellular and molecular mechanisms of GPR92 stimulation-mediated anti-inflammatory effects in islets that will mitigate obesity-induced β cell dysfunction. This study should lead to a better understanding of how the new G protein-coupled receptor GPR92 plays a role in regulating islet inflammation and can identify new therapeutic regimens in the field of type 2 diabetes.

PI_NAMEs: OH, DAYOUNG  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: 12q13;Abnormal Cell;Adipose tissue;Affect;Agonist;Anti-Inflammatory Agents;Antiinflammatory Effect;Beta Cell;Binding;Biochemical;Biological;Biological Assay;Cell Communication;Cell Physiology;Cells;Cellular Structures;chemokine;Chronic;Coculture Techniques;Computer Simulation;cytokine;Cytoplasm;Data;design;Diabetes Mellitus;Diet;diet-induced obesity;Down-Regulation;Endocrine;Exhibits;exosome;extracellular vesicles;Failure;farnesyl pyrophosphate;feeding;Functional disorder;G-Protein-Coupled Receptors;Genes;Genetic;genome wide association study;Glucose;High Fat Diet;Human;Hyperinsulinism;Image;Immune;impaired glucose tolerance;Impairment;in vivo;Inflammation;Inflammatory;Inflammatory Response;Insulin;Insulin Resistance;insulin secretion;intercellular communication;Ions;islet;Islets of Langerhans;Knockout Mice;Link;Liver;Macrophage;Mediating;Medicine;Metabolic;mevalonate;MicroRNAs;Microscope;Mitochondria;models and simulation;Molecular;Molecular Target;Mus;Muscle;Nanotubes;Nature;NF-kappa B;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutics;Obese Mice;Obesity;Organ;Pathogenesis;Pathway interactions;pharmacologic;Phenocopy;Phenotype;Physiological;Play;prevent;Production;programs;Property;Publications;Publishing;receptor;Regimen;Regulation;Reporting;response;Role;Signal Transduction;Site;Site-Directed Mutagenesis;Structure;Structure of beta Cell of islet;Systems Biology;Testing;Therapeutic;Tissues;transcriptome;type I and type II diabetes

PROJECT_TITLE: Regulation of GPCR-mediated intercellular communication in islets

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Genetics;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE During embryonic development of the pulmonary alveolus, a common progenitor gives rise to two distinct epithelial cell types that must be differentiated prior to birth for newborns to breathe. Recent work suggests that one of those cell types retain stemness for a period after birth, suggesting a novel mode of molecular regulation. We propose a hypothesis ––and our data strongly support–– that a developmentally timed repressor of stemness is activated to reinforce cell fate that, during adulthood, is dynamically toggled after injury to re-access stemness and promote repair; if true, this hypothesis will update the model of differentiation of the alveolar epithelium and have fundamental implications for understanding lung disease and regeneration, which we begin to investigate in this proposal.

PI_NAMEs: BROWNFIELD, DOUGLAS GLENN (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Ablation;Adult;Alveolar;alveolar epithelium;Alveolus;ATAC-seq;Attenuated;Bioinformatics;Birth;Bleomycin;Breathing;CCAAT-Enhancer-Binding Proteins;Cell Death;Cell Differentiation process;Cell Maturation;Cell secretion;cell type;Cells;ChIP-seq;Complex;Cues;Data;Defect;Development;Distal;Down-Regulation;Embryonic Development;Epigenetic Process;Epithelial Cells;Epithelium;experimental study;Fibroblast Growth Factor;Fibrosis;fibrotic lung;functional status;Gases;Gene Expression;gene repression;Gene Targeting;Genes;Genetic;Genetic Transcription;Image;in vivo;Injury;injury and repair;innovation;insight;Investigation;Lung;lung development;Lung Diseases;lung regeneration;lung repair;Maintenance;Mediating;Modeling;Modification;Molecular;mosaic;mouse model;multiple omics;Natural regeneration;Newborn Infant;notch protein;novel;novel diagnostics;novel therapeutics;overexpression;Patients;Perinatal;Play;Polycomb;premature;progenitor;programs;Protein C;Pulmonary alveolar structure;Pulmonary Fibrosis;Pulmonary Surfactants;Regulation;repaired;Reporting;Repression;Role;Signal Transduction;single-cell RNA sequencing;spatiotemporal;stem cell differentiation;stemness;Stretching;Surface;surfactant;Testing;Therapeutic;Thinness;Tissues;transcription factor;Transgenic Mice;Update;Work

PROJECT_TITLE: Molecular Determinants of the Alveolar Epithelial Plasticity Window

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Genetics;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Narrative: Autosomal dominant osteopetrosis type 2 (ADO2) is a rare sclerotic bone disorder resulting from impaired osteoclastic bone resorption most commonly due to mutations in the Chloride Channel 7 gene. Clinical manifestations include fractures, osteonecrosis (particularly of the jaw), osteomyelitis, blindness, and bone marrow failure. The goals of this study are to 1) identify clinically relevant biological and patient-reported outcomes; and 2) use previously obtained data along with data obtained during this 3-year study to determine the natural history of ADO2, including the rate of disease progression, to inform the design of future clinical trials.

PI_NAMEs: ECONS, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Adult;Affect;Age;Albers-Schonberg disease;Alleles;Animal Model;Appearance;autosome;Award;Biological;Biological Markers;Biometry;Blindness;bone;Bone Density;Bone Diseases;Bone marrow failure;Bone necrosis;Bone Resorption;Cell Culture Techniques;Chloride Channels;Clinical;Clinical Trials;Clinical Trials Design;clinically relevant;cohort;Collaborations;Conduct Clinical Trials;Data;Data Collection;Dedications;design;disability;Disease;Disease Marker;Disease Outcome;Disease Progression;Dominant-Negative Mutation;early childhood;effective therapy;Electronics;Endocrinology;Family;follow-up;Fracture;Functional disorder;Future;Genes;Goals;Grant;Hematopoietic Stem Cell Transplantation;Heterozygote;Human;Impairment;in vivo;Individual;Internal Medicine;Intervention Studies;Jaw;knock-down;Laboratories;Longterm Follow-up;Maxilla;Measurement;Measures;Medical Records;meetings;member;Metabolic Bone Diseases;Modeling;Morbidity - disease rate;mouse model;multidisciplinary;Mus;mutant;Mutation;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural History;novel marker;novel therapeutic intervention;novel therapeutics;Observational Study;Online Systems;Osteoclasts;Osteomyelitis;Outcome;Pain;Patient Outcomes Assessments;patient registry;Patient-Focused Outcomes;Patients;Pediatrics;Penetrance;Phenotype;Physical therapy;population based;preclinical study;predictive marker;programs;prospective;Prospective Studies;Quality of life;radiological imaging;Radiology Specialty;recruit;Registries;Research Personnel;Risk Factors;Sampling;Secure;Severities;Severity of illness;Source;Study Subject;Surveys;Testing;Therapeutic Clinical Trial;Therapeutic Effect;Time;Validation;Variant;Work

PROJECT_TITLE: Autosomal Dominant Osteopetrosis: A Natural History Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 KM (M2)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_NAME: COLLEGE OF STATEN ISLAND

PHR: Liquid helium is essential for the continued operation of several high-end magnetic resonance instruments at the College of Staten Island. Given the increased scarcity of helium as a resource, we propose to acquire and install a system that allows recycling and re-liquefying the helium used in these instruments. This will ensure the continued and reliable operation of these instruments that are essential in research dealing with biomedical questions including pain management, immunity, cancer therapy, diabetes and periodontal disease.

PI_NAMEs: POGET, SEBASTIEN F (contact)

PROGRAM_OFFICER_NAME: BECKETT, DOROTHY

PROJECT_TERMS: Anti-Bacterial Agents;antimicrobial;Antineoplastic Agents;Area;biomedical facility;Biomedical Research;biophysical analysis;biophysical techniques;Biophysics;career preparation;Chemicals;Chemotherapy-Oncologic Procedure;college;Consumption;cryostat;Dental;doctoral student;Drug Delivery Systems;Electron Spin Resonance Spectroscopy;Ensure;evaporation;experimental study;Faculty;Fees;Friends;Funding;Future;Gases;Helium;Human;Immune;Inflammatory;Institution;instrumentation;Island;Liquid substance;Magnetic Resonance;Measurement;Mediating;Medical;Medicine;Membrane;metalloenzyme;method development;nanoparticle drug;Natural Gas;Natural Immunity;Natural Resources;Neurobiology;Nuclear Magnetic Resonance;Peptides;Polymer Chemistry;Preparation;Price;Principal Investigator;Recovery;Recycling;Research;Research Personnel;Research Project Grants;Resistance development;Resources;S100A12 gene;Sampling;sensor;Singlet Oxygen;Sodium Channel;structural biology;Synthesis Chemistry;System;Techniques;Time;Toxin;Training;undergraduate student;United States National Institutes of Health;Visit;voltage

PROJECT_TITLE: Acquisition of a Liquid Helium Recycling System to Ensure Continued Viability of Magnetic Resonance Facilities for Biomedical Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (30)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Prevention;Substance Misuse

ORG_CITY: KINGSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE Community reintegration time following residential substance use disorder (SUD) treatment is a critically vulnerable that is characterized by high rates of return to use. This proposal will technologiesuse cutting-edge to identify time-sensitive proximal predictors of return to use during community reintegration. This knowledge is needed to develop evidence-based tools to prevent and/or delay return to use during community reintegration.

PI_NAMEs: WEISS, NICOLE HOLLAND (contact)

PROGRAM_OFFICER_NAME: MULFORD, CARRIE FRIED

PROJECT_TERMS: Abstinence;Acute;Address;Adult;Affect;Area;Autonomic Dysfunction;Autonomic nervous system;Biosensor;Buffers;Clinical;community reintegration;comorbidity;Coupled;craving;Data;Detection;Diagnostic;diagnostic biomarker;Ecological momentary assessment;Emotional;Environment;evidence base;Exhibits;experience;Foundations;Goals;heart rate variability;high risk;improved;Individual;Inpatients;Intervention;Knowledge;Link;longitudinal design;Mental Health;Methodology;Methods;Monitor;National Institute of Drug Abuse;negative affect;Outcome;Pain;Persons;Physiology;Population;Population Intervention;predictive modeling;prevent;preventive intervention;Recovery;Regulation;Reporting;Research;return to use;Risk;Risk Factors;Sampling;stem;Stress;substance use;Substance Use Disorder;substance use treatment;substance user;Testing;Time;tool;Undifferentiated;United States;virtual;wearable sensor technology;Work

PROJECT_TITLE: Interplay of Affect and Physiology in the Real-Time Prediction of Return to Use During Community Reintegration of Substance Users


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: FARMINGTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Narrative Placenta accreta is a serious disease with dysregulated placental invasion, molecular mechanisms of which are poorly understood. We propose an integrated study of accreta elucidating key components associated with scar induced placenta accreta and possible diagnostic and targetable mechanisms of this highly invasive condition.

PI_NAMEs: BREWER, MOLLY A.;KSHITIZ, FNU  (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Affect;Area;Automobile Driving;Biology;Biomechanics;Biomedical Engineering;biophysical properties;Biophysics;Birth;Cells;Cellular biology;Cesarean section;Characteristics;Chemotactic Factors;Cicatrix;Clinical;Collagen;comparative;Computing Methodologies;CSF3 gene;Cues;Cyclic AMP-Dependent Protein Kinases;cytokine;Decidua;Decidual Cell Reactions;density;Diagnostic;Disease;Distal;economic cost;Endometrial;Endometrium;Equilibrium;Etiology;Fibroblasts;Frequencies;Genes;Genetic Transcription;Genomics;Hemorrhage;Histologic;Homeostasis;Human;Hypoxia;Hysterectomy;IL8 gene;in vitro Model;Inflammation;Inflammatory;Inflammatory Response;instrumentation;Invaded;Left;Light;Link;Mammals;maternal condition;Maternal-Fetal Exchange;Measurement;Measures;mechanical signal;mechanotransduction;Mediating;Medical;Metabolism;Microfluidics;Microscopy;Modeling;Molecular;multiple omics;Muscle;myometrium;nano;Nanotopography;Nature;NF-kappa B;novel;Operative Surgical Procedures;Outcome;paracrine;Pathogenesis;Pathology;Patients;Permeability;Phenotype;Phosphorylation;Physiological;Piezo 1 ion channel;Placenta;Placenta Accreta;Placentation;Play;Pregnancy;Premature Birth;prevent;Production;protein activation;Protein Kinase C;psychologic;recruit;Regulatory Element;Resistance;response;Risk Factors;Role;Sampling;Signal Transduction;Stromal Invasion;System;technology platform;Testing;Therapeutic;Tissues;tool;transcriptomics;Trauma;trophoblast;Uterus;Villous;Woman

PROJECT_TITLE: Dysregulation of Endometrial Invasibility Proximal to Uterine Scar as a Mechanism of Placenta Accreta

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Lung;Rare Diseases

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE There are no pharmaceutical therapies that have proven efficacious for acute respiratory distress syndrome (ARDS), so treatment of the more than 200,000 patients diagnosed with ARDS each year in the US revolves around supportive care using mechanical ventilation. However, improperly set mechanical ventilation can lead to ventilator-induced lung injury (VILI), which contributes significantly to the annual ARDS mortality figure of 75,000. By elucidating the dynamic balance between the biophysical mechanisms responsible for the progression and resolution of VILI, we will be able to identify optimal ventilation strategies that adapt to patient- specific pathophysiology in order to minimize this injurious phenomenon and thus reduce ARDS mortality.

PI_NAMEs: BATES, JASON HT (contact);GAVER, DONALD P.;KOLLISCH-SINGULE, MICHAELA CHRISTINA

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Air;atelectrauma;Biophysical Process;Blood gas;cancer survival;Cells;clinically relevant;Computer Models;Data;design;Development;Diagnosis;electric impedance;Epithelial Cells;epithelial injury;Epithelium;Equilibrium;experimental analysis;experimental study;Extravasation;Family suidae;Fingers;Functional disorder;Future;Generations;Geometry;Goals;healing;Heterogeneity;improved;improved outcome;In Vitro;in vivo;individual patient;Injury;injury and repair;Link;Lung;Lung Capacity;lung injury;Measurement;Measures;Mechanical ventilation;Medical;Microfluidics;Modeling;Monitor;monolayer;mortality;Mus;Nature;Patient-Focused Outcomes;Patients;Periodicity;Pharmacologic Substance;Physiological;Plasma;porcine model;predictive modeling;preservation;pressure;prevent;Prevention;Property;Recovery;recruit;Regimen;repaired;reparative capacity;Research;Resolution;respiratory;success;Supportive care;surfactant;System;Testing;Time;tissue repair;Tissues;ventilation;Ventilator-induced lung injury

PROJECT_TITLE: Preserving Epithelial Barrier Integrity in Ventilator-Induced Lung Injury

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ORG_CITY: CHARLESTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE High prevalence of intestinal diseases, such as fibrosis and colon cancer, suggests that we still don’t fully understand their underlying causes. We have discovered a mechanism linking colon tissue integrity, which is broadly compromised in these diseases, with regulation of cell behavior through molecules called microRNAs (miRNAs). The present proposal aims to gain insights into the cross-talk of this mechanism with biomechanical changes in the colon tissue, a common feature of intestinal diseases, leading to novel therapeutic approaches.

PI_NAMEs: KOURTIDIS, ANTONIS  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Acceleration;Actins;Adherens Junction;Anti-Inflammatory Agents;Architecture;Binding;Biological Assay;Biomechanics;cell behavior;cell growth;cell motility;cell transformation;Cell-Cell Adhesion;Cells;Cellular Structures;Colon;colon cancer cell line;Colon Carcinoma;Colonic Diseases;Colonic Neoplasms;Colorectal;Complex;Cues;Cytoskeleton;Data;Deposition;Development;Disease;Disease Progression;E-Cadherin;Epithelial Cells;Epithelium;Extracellular Matrix;Fibrosis;Future;High Prevalence;Image;In Vitro;in vivo Model;Inflammatory Bowel Diseases;innovation;insight;Intestinal Diseases;Link;loss of function;Malignant Neoplasms;mechanical signal;Mechanical Stress;Mediating;member;Messenger RNA;Microprocessor;MicroRNAs;Neoplasm Metastasis;novel;novel therapeutic intervention;Oncogenes;Organoids;overexpression;Patients;Polyps;premalignant;programs;Proteins;recruit;Regulation;Reporting;Risk Factors;RNA;RNA Interference;Role;Sampling;Stress;Structure;Testing;therapeutic RNA;Tissues;tool;tumor;tumor growth;tumor progression;tumorigenesis;tumorigenic;Up-Regulation;Work

PROJECT_TITLE: Colon cell mechanoregulation through an E-cadherin - associated RNAi machinery

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Lymphatic Research;Women's Health Research

ORG_CITY: AUSTIN

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Lymphovascular space invasion (LVSI), the presence of tumor emboli in blood and lymphatic vasculature, is among the most robust predictors of metastatic progression, however, our inability to fully recreate LVSI in vitro has severely limited our mechanistic understanding of pathways that mediate its formation and persistence. Leveraging our highly versatile, functional, in vitro vascularized breast tumor platform, we propose to answer three major questions relating to LVSI: What mechanisms promote 1) formation, 2) migration, and 3) intra-vessel survival of tumor emboli? If successful, we will define the signaling steps that promote LVSI formation and survival in vasculature and identify critical therapeutic targets related to cancer progression.

PI_NAMEs: DEBEB, BISRAT G;RYLANDER, MARISSA NICHOLE (contact);WOODWARD, WENDY A

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;advanced breast cancer;Affect;aggressive breast cancer;Animal Model;Animals;Anoikis;Apoptotic;Binding;Biological;Biomedical Engineering;BIRC4 gene;Blood;Blood Vessels;Breast;Breast Cancer Model;Breast Cancer Patient;cancer cell;CCL19 gene;CCL21 gene;Cell Communication;cell motility;Cell Survival;Cells;Characteristics;chemokine;Clinical;Clinical Research;Collagen;cytokine;Data;Dendritic Cells;Disseminated Malignant Neoplasm;Distant;E-Cadherin;Embolism;Epithelial Cells;Epithelium;Event;experimental study;Extracellular Matrix;Fiber;Gelatinase B;Gene Expression;Home;Homing;Immune;In Vitro;in vivo;in vivo Model;Infiltration;inflammatory breast cancer;interest;Invaded;Kinetics;Ligands;lymph flow;Lymphatic;Lymphatic function;lymphatic pump;lymphatic vasculature;Lymphovascular;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;Mammary Neoplasms;Mechanics;Mediating;Mesenchymal;Microfluidics;migration;Modeling;multiplexed imaging;Neoplasm Metastasis;neoplastic cell;novel;Oncogenic;Organ;Pathway interactions;Patients;Permeability;pharmacologic;Physiologic pulse;Porosity;pre-clinical;Pre-Clinical Model;Primary Neoplasm;Process;Property;Proteins;Research Personnel;Resistance;Role;Sampling;screening;Signal Transduction;System;Testing;Therapeutic;therapeutic target;Time;Tissue Engineering;Tissues;trafficking;tumor;Tumor Cell Migration;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;Variant;Vascularization;Work

PROJECT_TITLE: Deciphering the Mechanism of Lymphovascular Space Invasion Using a Lymphovascularized Bioengineering Breast Stromal Platform

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Prevention;Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE Lynch Syndrome (LS), a hereditary cancer predisposition syndrome associated with DNA mismatch repair (MMR) pathway impairment, is characterized by a high shared frame shift neoantigen burden and T cell infiltration, which results in improved response to treatment with immune checkpoint inhibitors (CPI). We will investigate the hypothesis that high quality shared neoantigen expression, and a functional T cell repertoire capable of trafficking to and clearing MMR deficient lesions, deters progression of premalignant polyps to overt cancer in Lynch Syndrome. We propose to: (i) map the spectrum of novel and shared neoantigen-expressing frameshift mutations in pre-cancerous colorectal polyps, (ii) identify and track fs-specific TCRs capable of recognizing quality fs-neoantigens and (iii) determine features of the polyp microenvironment that promote tumor development to identify actionable targets for prevention/interception strategies.

PI_NAMEs: BHARDWAJ, NINA  (contact);LUCAS, AIMEE L;SAMSTEIN, ROBERT M

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Algorithms;Antigen Presentation;antigen-specific T cells;Antigens;Bar Codes;biobank;Biological Assay;Blood;cancer predisposition;cancer prevention;cancer risk;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Characteristics;cohort;Colon;Colonic Polyps;Colorectal Polyp;Computational Biology;CTLA4 gene;cytokine;Data;Defect;density;design;Development;Disease;DNA;Epithelium;Epitopes;Evolution;Exclusion;exhaustion;exome;Exposure to;Frameshift Mutation;Frequencies;Future;Genomics;Goals;Hereditary Malignant Neoplasm;Hereditary Nonpolyposis Colorectal Neoplasms;High-Frequency Microsatellite Instability;Immune;immune activation;Immune checkpoint inhibitor;Immune response;immunogenic;immunogenicity;Immunohistochemistry;Immunologic Surveillance;Immunoprevention;Impairment;improved;In Vitro;Infiltration;Inflammatory;Inherited;insight;Interleukin-12;Lesion;Malignant Neoplasms;Maps;Microsatellite Instability;Mismatch Repair;Mismatch Repair Deficiency;Modeling;multidisciplinary;Mutation;Myeloid-derived suppressor cells;neoantigens;novel;Pathway interactions;Patients;Peptide/MHC Complex;peripheral blood;Point Mutation;Polyps;Population;Precancerous Polyp;Predisposition;premalignant;Premalignant Cell;prevent;Prevention;Prevention strategy;Productivity;programmed cell death ligand 1;Proxy;Resistance;RNA;routine screening;Screening for cancer;screening guidelines;screening program;Shapes;single-cell RNA sequencing;Site;statistics;Syndrome;T cell infiltration;T cell receptor repertoire sequencing;T cell response;T-Cell Receptor;T-Lymphocyte;Time;Tissue Sample;Tissues;TNF gene;tool;trafficking;transcriptome sequencing;transcriptomics;treatment response;tumor;Tumor Antigens;Tumor Cell Line;Tumor Immunity;tumor immunology;Tumor Promotion;Vaccination;vaccine development;Validation;Work

PROJECT_TITLE: Immune determinants modulating cancer development in Lynch Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (J1)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Endocrine Disruptors;Rural Health

ORG_CITY: TERRE HAUTE

ORG_NAME: INDIANA STATE UNIVERSITY

PHR: Project Narrative A high-resolution gas chromatograph-mass spectrometer at Indiana State University will enable three research projects with direct impacts on public health; a new course in metabolomics and proteomics; and provide our students hands-on training with state-of-the-art biomedical research instrumentation. This will enhance the research and teaching environment at ISU and is essential to maintaining a competitive biomedical workforce in our state.

PI_NAMEs: FITCH, RICHARD W (contact)

PROJECT_TERMS: Alkaloids;Amination;Animals;base;Biochemistry;Bioinformatics;Biology;Biomedical Research;Blood capillaries;Chemicals;Chemistry;Chromatography;Complex Mixtures;Coupled;Cytochrome P450;Data;design;Education;Education Projects;Educational process of instructing;Electrons;Eligibility Determination;Environment;Environmental Science;experience;Faculty;faculty research;Gases;graduate student;Grant;Indiana;Informatics;Institution;instrument;ionization;laboratory curriculum;Life;lipidomics;mass spectrometer;Measurement;Metabolism;metabolomics;Mission;Molecular;Monitor;National Center for Advancing Translational Sciences;National Institute of Drug Abuse;National Institute of Environmental Health Sciences;National Institute of General Medical Sciences;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Pattern;Pesticides;Poison;Poly-fluoroalkyl substances;programs;Proteomics;Pseudomonas aeruginosa;public database;Rana;Reaction;Records;Research;Research Project Grants;Resolution;rural environment;Students;tandem mass spectrometry;Techniques;undergraduate research experience;undergraduate student;underserved community;Universities;urban setting

PROJECT_TITLE: A Gas Chromatograph-Mass Spectrometer Supporting Undergraduate Biomedical Research and Education


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: EAST LANSING

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE There are over 10,000 new cases of Multiple Sclerosis (MS) diagnosed in the US each year and over 2 million people worldwide have MS, for which there is currently no cure, nor a simple test to facilitate physician diagnosis. Most researchers in the field of MS agree that damage to the myelin sheath surrounding nerve bundles is a determinant in MS, as is the breakdown of the blood brain barrier (BBB) that protects the nervous system (and myelin sheath) from potential toxins and/or pathogens in the bloodstream. Here, an investigate team of researchers proposes that hypermetabolic red blood cells are leading to an increase in certain molecules in the bloodstream that may be stimulating other immune cells to harm BBB integrity, resulting in myelin damage and onset of MS symptoms.

PI_NAMEs: BAKER, LANE A.;MARTIN, ROBERT SCOTT;SPENCE, DANA M (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: 3-Dimensional;Affect;Agreement;Amino Acids;Area;Basic Science;Binding;Blood;Blood - brain barrier anatomy;Blood Circulation;blood glucose regulation;Brain;C-Peptide;Cell membrane;Cells;Central Nervous System;Cicatrix;Circulation;Clinical Research;Clinical Sciences;Data;design;Diagnosis;Disease;Dose;Erythrocytes;experience;FDA approved;Fiber;fluorodeoxyglucose;Glucose;Glucose Transporter;Glycolysis;Heart;Human;Image;Immune;Immune system;In Vitro;in vivo;in vivo imaging;Insulin;Intercellular Fluid;Interferon-beta;Interferons;Lactic acid;Lesion;Link;Literature;Magnetic Resonance Imaging;Measurable;Measurement;Measures;Mediating;meetings;Membrane;Metabolism;Microfluidics;Modeling;Multiple Sclerosis;multiple sclerosis patient;Myelin;Myelin Sheath;nano;nanoscale;Nerve;Nerve Fibers;Nervous System;Nervous System Disorder;Neurologic;novel;Onset of illness;Pancreas;Pancreatic Hormones;pathogen;Peptides;Permeability;Persons;Pharmacodynamics;Physicians;Positron-Emission Tomography;pressure;Production;Property;Proteins;Publishing;Radiopharmaceuticals;radiotracer;Reporting;Research Personnel;Resistance;Resolution;response;scanning ion conductance microscopy;single molecule;Skeletal Muscle;SLC2A1 gene;Spinal Cord;standard of care;Stimulus;Symptoms;Testing;Time;Tissues;tool;Toxin;United States;uptake;Work

PROJECT_TITLE: From single molecule to microfluidic 3D tissue platforms: novel multiscale tools to investigate hyper-stimulated immune cells in the circulation

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Physical Injury - Accidents and Adverse Effects;Prevention;Rural Health

ORG_CITY: MARTIN

ORG_NAME: UNIVERSITY OF TENNESSEE MARTIN

PHR: Project Narrative: The DXA scanner is essential for us to recruit & retain faculty and students into our public health, health sciences, and biomedical areas and continue to provide health screenings to our underserved community. We are the only body composition scan in 90-miles.

PI_NAMEs: SHERMAN, TODD  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: abdominal aorta;Age;Aging;Area;Athletic;Biology;Body Composition;Bone Density;calcification;career;Clinic;Clinical;Collaborations;Communities;Core Facility;Discipline of Nursing;Dual-Energy X-Ray Absorptiometry;Education;Engineering;Faculty;Faculty Recruitment;fracture risk;Goals;Health;Health Professional;Health Sciences;Healthcare;Hospitals;Hour;Image;Individual;Injury;Institution;interdisciplinary collaboration;Measures;member;Mental Health;Metabolic;nutrition;Orthopedics;physical conditioning;Prevention;Psychology;Public Health;Radiation;Reporting;Research;Rural Community;Scanning;science education;screening;Stress Fractures;stress management;student athlete;Student recruitment;Students;System;Technology;Training;Travel;Universities

PROJECT_TITLE: Hologic DXA Scanner


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Lung;Rare Diseases;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Scrub typhus is a major public health problem, especially in the Asia-Pacific regions, yet our knowledge of this disease is very limited. Using four different animal models and comprehensive approaches, we will examine mechanisms underlying vascular dysfunction and disease pathogenesis. This study will improve public health.

PI_NAMEs: LIANG, YUEJIN ;SOONG, LYNN  (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Acute;adaptive immunity;Address;Animal Model;Animals;Antigens;Asia;Bacteria;Biological;Biological Markers;Biological Models;biological research;Blood;Blood Cells;Blood specimen;Blood Vessels;Brain;brain tissue;C Type Lectin Receptors;C57BL/6 Mouse;CD4 Positive T Lymphocytes;Cell Culture Techniques;Cell Death;Cell model;Cell Physiology;Cell Shape;Cell Survival;Cells;Cessation of life;Clinical;clinical translation;clinically relevant;Coculture Techniques;Color;Dendritic Cells;Disease;Dose;Endothelial Cells;Endothelium;Feasibility Studies;Flow Cytometry;Future;Genetic;genetic resistance;Goals;Grant;Homeostasis;Human;Immune;improved;In Vitro;Inbred Mouse;Inbreeding;Infection;Infection Control;infection risk;Inflammation;Injury;Investigation;Kidney;knockout gene;Knockout Mice;Knowledge;Label;Life;Ligands;Link;Lung;Mediating;Modeling;Molecular;mortality;mouse model;Mus;Myelogenous;novel;Organ;Orientia tsutsugamushi;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Perfusion;peripheral blood;Persons;Phagocytes;Pilot Projects;Populations at Risk;Predisposition;Process;programs;Protein Tyrosine Kinase;Proteomics;Protocols documentation;Public Health;Pulmonary Inflammation;receptor;Receptor Protein-Tyrosine Kinases;Regulation;repaired;Reporting;Repression;Research;response;Scrub Typhus;Serum;Side;Spleen;synergism;System;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Tissue Banks;tissue injury;tissue repair;Tissues;TNF gene;tool;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;translational potential;Translational Research;Vaccines;Validation;Vascular Diseases;vascular stress;Vasculitis

PROJECT_TITLE: Pathogenic Mechanisms of Vascular Dysfunction in Scrub Typhus

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative American Indians (AI) are greatly affected by opioid use and opioid-related overdose (OD) mortality. Overdose prevention vending machines (ODPVMs) that freely dispense naloxone have been shown to reduce opioid OD fatalities. The goal of this project is to evaluate the implementation of ODPVMs within AI Tribes and the corresponding impact on reducing opioid-related OD mortality on tribal lands.

PI_NAMEs: GAINES, TOMMI LYNN (contact);KNOX, AMY

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Address;Adoption;Affect;Age;Alaska Native;American Indian community;American Indian Tribe;American Indians;Applied Research;Area;Attention;Belief;California;Communities;community based participatory research;Community based prevention;community building;County;Cross-Sectional Studies;Data;Development;Ethnic Population;evidence base;experience;Exposure to;Family;Fatality rate;Friends;Goals;Harm Reduction;health equity;implementation evaluation;implementation process;implementation strategy;improved;Indian reservation;Individual;Inequality;Knowledge;land use;Language;mortality;Naloxone;naloxone dispensing;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use;Overdose;overdose death;overdose prevention;Overdose reduction;Overdose reversal;Pharmaceutical Preparations;Phase;Population;Positioning Attribute;prescription opioid misuse;prevent;Prevention strategy;Principal Investigator;Process;Public Health;racial population;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Research Design;Research Infrastructure;Research Personnel;Risk;Services;Spatial Distribution;Statistical Distributions;Structure;Testing;Time;trend;tribal community;tribal lands;tribal leader;Tribal-academic partnership;Tribes;United States;United States Dept. of Health and Human Services;uptake;Work

PROJECT_TITLE: Evaluating Vending Machines providing Naloxone to Prevent Overdose in American Indian Communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-S (56)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Relevance Real-life learning occurs through a combination of positive and negative feedback in the form of reward and punishment, respectively. Dopamine neurotransmitters are known to be central for learning from rewards, but very little is known about how these molecules are involved in learning from both rewards and punishments despite the deficits in these behaviors observed in Parkinson’s disease and other disorders implicating dopamine dysregulation. The goal of this proposal is to measure how dopamine signals are involved in learning from rewards and punishments by recording these molecules in monkeys as they perform a variety of tasks to test the effects of these positive and negative incentives on simple-associative, cognitive, and motor forms of learning.

PI_NAMEs: SCHWERDT, HELEN N (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Striatal Dopamine Signals Underlying Valence-Dependent Learning


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research is relevant to human health as it explores novel mechanisms of pathogenicity employed by three families of bacterial toxins: VopF/VopL, SipA, and MavH, produced by pathogenic Vibrio, Salmonella, and Legionella strains. Understanding such mechanisms will help to clarify the roles of the actin machinery in defense against pathogenic microorganisms, improve our ability to treat life-threatening infectious diseases, and lead to the creation of innovative research strategies, thereby satisfying several criteria relevant to NIH’s mission.

PI_NAMEs: KUDRYASHOV, DMITRI  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Activities of Daily Living;Address;Affect;Antibiotic Resistance;Bacterial Toxins;Binding;Biochemical;Cells;Cellular biology;Characteristics;climate change;cofilin;Collaborations;Communicable Diseases;Complement;Complex;Cryoelectron Microscopy;Cytoskeleton;emerging pathogen;Epithelial Cells;Equilibrium;Exhibits;Family;fascin;Filament;Fimbrin;Fluorescence Anisotropy;Fluorescence Microscopy;Future;Goals;Health;Human;human pathogen;improved;In Vitro;innovation;inorganic phosphate;insight;Integration Host Factors;interest;Invaded;Kinetics;Knowledge;Learning;Legionella;Legionella pneumophila;Life;Light;Link;Liposomes;live cell microscopy;Mediator;Membrane;Microfilaments;Microfluidics;microorganism;Microscopy;Mission;Modality;Modification;Molecular;Monitor;Multi-Drug Resistance;neural network;novel;operation;pathogen;pathogenic bacteria;Pathogenicity;Pharmaceutical Preparations;Phosphatidylinositols;Physiology;plastin;polymerization;Polymers;Process;profilin;Property;Proteins;Pyrenes;reconstruction;Recycling;Research;Role;Salmonella;Salmonella enterica;Side;single molecule;small molecule;Societies;stoichiometry;structural biology;Structure;Targeted Toxins;Techniques;Testing;thymosin beta(4);Toxic effect;Toxicology;Toxin;United States National Institutes of Health;Vibrio;Vibrio cholerae;Vibrio parahaemolyticus

PROJECT_TITLE: Molecular Mechanisms of Bacterial Toxins Targeting the Actin Cytoskeleton

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Traumatic Head and Spine Injury

ORG_CITY: WASHINGTON

ORG_NAME: HOWARD UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The proposal outlines a requisition plan for a Zeiss Axioscan 7 Slide Scanner for the Howard University Imaging Core. This advanced instrument enables precise, high-throughput analysis of histological samples, catalyzing groundbreaking discoveries in biomedical research. It significantly enhances our institution's research capabilities and improves the quality of education in addressing health disparities and promoting equity among underrepresented groups.

PI_NAMEs: TU, TSANG-WEI  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Advisory Committees;Advocate;Affect;Area;Biomedical Research;congenital cytomegalovirus;Cost Savings;Dedications;Disease;Disparity population;Education;Equipment;experience;Fluorescence;Fortification;Fostering;Funding;Gene Delivery;Grant;Head and Neck Cancer;health disparity;health equity;Health Sciences;Human Resources;Image;imaging system;Imaging Techniques;Immunotoxins;improve minority health;Individual;Institution;interdisciplinary collaboration;Maintenance;Microscope;Microscopy;Minor;Minority Groups;Mission;Opioid;Oral health;Outcome;Performance;Polarization Microscopy;preclinical imaging;programs;Racial Equity;Research;Research Infrastructure;Research Personnel;Scanning;Scientist;Slide;Students;Supervision;supported housing;Training;Traumatic Brain Injury;Underrepresented Populations;United States National Institutes of Health;Universities;Ventilatory Depression;Zika Virus

PROJECT_TITLE: Microscope Slide Scanner


ORG_CITY: DALLAS

ORG_DEPT: PATHOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE While mucins are a heavily O-glycosylated protein, a novel mouse model demonstrates that N-glycosylation is essential for proper mucin maturation and barrier protection. Furthermore, these insights from glycobiology revealed a simple carbohydrate can be used to treat gastrointestinal disorders by improving mucus barrier production.

PI_NAMEs: SORELLE, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Acceleration;Affect;Alleles;Apoptosis;Bacteria;Bypass;Calories;Carbohydrates;Cell Death;Cell Survival;Cessation of life;cohort;Colon;conditional knockout;Congenital disorders of glycosylation;Data;Defect;Diarrhea;Dimerization;Diphenhydramine;Disease;Embryo;endoplasmic reticulum stress;Etiology;experimental study;feasibility testing;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal tract structure;Gel;Germ-Free;Glycobiology;Glycoproteins;glycosylation;Goals;Goblet Cells;Golgi Apparatus;gut inflammation;Hereditary Disease;Human;human disease;improved;In Vitro;in vivo;Inflammation;Inflammatory Bowel Diseases;inhibitor;inorganic phosphate;insight;intestinal barrier;Intestinal Diseases;intestinal homeostasis;Intestines;Invaded;irritation;Isomerase;Knock-in;Link;Mannose;mannose 6 phosphate;Measures;Methods;microbiome;Modeling;Molecular;mouse model;Mouse Strains;Mucin-2 Staining Method;Mucins;Mucous body substance;Mus;mutant;Mutate;Mutation;N-Glycosylation Site;Names;novel;Organoids;Patients;Phenotype;Physiological;Physiological Processes;Polysaccharides;Post-Translational Protein Processing;Pre-Clinical Model;prevent;Production;protective effect;Protein Glycosylation;Protein-Losing Enteropathies;Proteins;Role;Site;Stomach;sugar;Symptoms;System;Testing;Therapeutic Intervention;Time;Ulcer;villin

PROJECT_TITLE: Improving intestinal symptoms in a Congenital Disorder of Glycosylation


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Dietary Supplements;Digestive Diseases;Hematology;Liver Disease;Nutrition

ORG_CITY: GAINESVILLE

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Public Health Relevance Iron is an essential nutrient for humans, yet it is toxic in excess; as such, iron deficiency and iron overload are both associated with significant morbidity. Body iron levels are dictated by the magnitude of dietary iron absorption, since excess iron cannot be efficiently excreted, and thus, intestinal iron absorption must be tightly controlled. This proposal seeks to decipher molecular aspects of intestinal iron absorption that have heretofore been unclear, with a long-term goal of developing therapeutic approaches to enhance iron absorption in iron deficiency and repress iron absorption in iron-overload disorders, such as hereditary hemochromatosis.

PI_NAMEs: COLLINS, JAMES F. (contact);HAMZA, IQBAL

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: absorption;Address;Adult;Affect;Affinity;Anemia;Animal Model;Apical;apical membrane;Arthralgia;basolateral membrane;Biology;Cardiomyopathies;Child;Cirrhosis;Clinical;cognitive development;Coupled;Custom;Cytosol;cytotoxic;Data;design;Development;Diabetes Mellitus;Diet;dietary;dietary heme;Dietary Iron;Disease;Duodenum;Elderly;Endocytic Vesicle;Endocytosis;Endosomes;Enteral;Enterocytes;Epithelium;European;Excretory function;experimental study;Family suidae;Freeze Drying;Genetic;Genetic Diseases;Goals;Growth;Heme;heme a;Heme Iron;heme oxygenase-1;Hemochromatosis;hepcidin;Hereditary hemochromatosis;high risk;Homeostasis;Homologous Gene;Hormones;Human;Hypogonadism;Impaired cognition;Impairment;In Vitro;in vivo;Individual;Infant;inhibitor;Intestines;Investigation;Iron;iron absorption;iron deficiency;Iron deficiency anemia;Iron Overload;Lactation;Liver;Mammals;Mediating;Membrane;Menstruation;Micronutrients;mimetics;Minor;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;mutant;Mutation;novel;Nutrient;Oral;Organ Culture Techniques;Organoids;Osteoporosis;Output;Oxidation-Reduction;Pathologic;Pathway interactions;Physiological;Pilot Projects;Plasma;Positioning Attribute;postnatal;Pregnancy;Pregnancy Complications;Pregnant Women;Process;Production;public health relevance;pup;Rattus;Repression;Research;Role;SLC11A2 gene;Sprague-Dawley Rats;Surface;Testing;Therapeutic;translational potential;Uncertainty;Weaning;Work

PROJECT_TITLE: Mechanisms of Intestinal Heme-iron Absorption in Rat Models of Iron Deficiency and Iron Overload

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]