NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Contraception/Reproduction;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Neisseria gonorrhoeae is an urgent public health threat with increasing case numbers, rising antibiotic resistance, and no protective vaccine. This work will investigate mechanisms by which the complement system disrupts bacterial envelope integrity and enhances antibacterial capacity of antibiotics and other immune effectors, and will explore the role of vaccine-elicited antibodies in augmenting these immune responses. Findings from this research will inform future therapeutic modalities and vaccine design against this high-priority pathogen.

PI_NAMEs: LAMB, EVAN R (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: adaptive immune response;Advanced Development;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Antibodies;antimicrobial;Bacteria;bactericide;Binding;Biological Assay;Biological Models;career;Cells;Chemosensitization;Clinical;combat;Complement;Complement 5a;complement C5b;Complement Membrane Attack Complex;complement system;Complex;cross immunity;Cross Reactions;cross reactivity;Cytolysis;Cytoplasm;Data;Deposition;Development;Disease;Ectopic Pregnancy;Electron Microscopy;emerging antibiotic resistance;Fertility;Flow Cytometry;fluorophore;Foundations;Future;Genetic Complementation Test;Goals;Gonorrhea;Gram-Negative Bacteria;Health;Host Defense;Human;Humoral Immunities;Image;Immune;Immune response;Immune system;Immunization;Immunize;Immunologic Factors;Immunologics;Impairment;In Vitro;Individual;Infection;Infertility;Inflammatory;inhibitor;Innate Immune Response;Knowledge;leukocyte activation;Mediating;Membrane;Meningococcal vaccine;microbial;Microscopy;Modality;Modeling;Mus;Neisseria;Neisseria gonorrhoeae;neutrophil;pathogen;Pathogenesis;Pelvic Inflammatory Disease;periplasm;Phagocytes;Phagocytosis;Physicians;Predisposition;prevent;priority pathogen;Process;programs;Proteins;Public Health;public health priorities;Recommendation;recruit;Research;Resistance;Risk;Role;Scientist;Sepsis;Serogroup B Neisseria meningitidis;Serum;Serum Proteins;Sexually Transmitted Diseases;Site;Structure;Testing;Therapeutic;Tissues;tool;Training;Transmembrane Domain;Vaccine Design;vaccine development;Vaccines;Vitronectin;Whole Blood;Work

PROJECT_TITLE: Defining mechanisms of complement-mediated killing of Neisseria gonorrhoeae

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: JACKSONVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Acute pancreatitis can proceed to a chronic condition but the molecular and cellular events driving this process are not well defined. This proposal focusses on how the acute pancreatitis-induced signaling molecule PKD1 may alter the immune landscape and the pancreatic microenvironment to favor the development of a chronic pancreatitis.

PI_NAMEs: STORZ, PETER  (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Acinar Cell;Acute;acute pancreatitis;Address;Affect;Animal Model;Animals;Antibiotics;Automobile Driving;Cells;Chronic;chronic pancreatitis;conditional knockout;Data;Development;Disease;Environment;Event;Fibrosis;Human;Immune;in vivo;Individual;Inflammatory;inhibitor;Lesion;Macrophage;Malignant neoplasm of pancreas;Mediating;Metaplasia;Methods;Molecular;Molecular Profiling;Mus;Natural regeneration;nutrition;Pain;Pancreas;Pancreatic Diseases;Pancreatitis;Phosphotransferases;Prevalence;prevent;Process;Protein Inhibition;Protein Kinase;Protein-Serine-Threonine Kinases;Resolution;Risk Factors;Rodent;Role;Sampling;Signal Induction;Signal Transduction;Signaling Molecule;targeted treatment;Testing;Therapeutic;Transgenic Animals;treatment strategy

PROJECT_TITLE: Protein Kinase D1 as a switch from acute to chronic pancreatitis

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Infectious Diseases;Otitis Media;Pediatric

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative We have developed three innovative methods to diagnose and monitor otitis media (OM). We have built a shortwave infrared (SWIR) fluorescence otoscope capable of targeted molecular imaging to distinguish bacterial otitis media from middle ear inflammation (TM) and implemented Spatial Offset Raman Spectroscopy (SORS) to provide molecular information regarding changes in the tympanic membrane and middle ear fluid. Lastly, we have developed a shortwave infrared otoscope to diagnose middle ear effusions based on the water absorption properties of shortwave infrared wavelengths.

PI_NAMEs: VALDEZ, TULIO ALBERTO (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: absorption;Accounting;Acute;Address;Algorithms;Anesthesia procedures;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;ATP-Binding Cassette Transporters;Bacteria;Bacterial Infections;bacterial metabolism;bacterial resistance;Biological Markers;Caspase;Cathepsins;Chemicals;Child;Childhood;Chronic;Classification;Clinical;clinical practice;clinical translation;Clinical Trials;Collagen;Collagen Type IV;Colony-forming units;cost estimate;Data;design;Development;Diagnosis;Diagnostic Imaging;Diagnostic Procedure;Ear;early childhood;effusion;Family;Fingerprint;Fluorescence;Glycoproteins;glycosylation;Goals;Gram-Negative Bacteria;Haemophilus influenzae;Health Care Costs;hearing impairment;Human;imaging capabilities;imaging modality;Imaging Techniques;improved;Infection;Inflammation;Inflammatory;innovation;Institution;Light;Lighting;Lipopolysaccharides;maltodextrin;Measurement;Medical;Methods;middle ear;middle ear conditions;middle ear fluid;Modality;Modeling;Molecular;molecular imaging;Molecular Probes;Molecular Target;Monitor;mouse model;Movement;Mucins;mucoid;multidisciplinary;Mus;noninvasive diagnosis;novel;novel diagnostics;Office Visits;Operating Rooms;Operative Surgical Procedures;Optics;Otitis Media;Otitis Media with Effusion;Otolaryngologist;Otoscopes;Otoscopy;pathogen;Patient imaging;Patients;pediatric patients;Pediatric Surgical Procedures;pediatrician;Phenylalanine;pre-clinical;primary care setting;prognostic;Prokaryotic Cells;Proline;Property;prototype;Raman Spectrum Analysis;random forest;Resistance;Resolution;Saline;Sampling;Serous;Short Waves;Shortwave Infrared Imaging;small molecule;Spectrum Analysis;Speculums;Streptococcus pneumoniae;Structure;Surgical incisions;Techniques;Testing;translational applications;Translational Research;Translations;treatment response;Tube;Tympanic membrane;Tympanometry;Tympanostomy;United States;Variant;Viscosity;Visible Radiation;Water;Work

PROJECT_TITLE: Molecular Imaging for diagnosis and monitoring of Otitis Media

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Z (47)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Despite intensive study of the actions of neuromodulatory systems on motoneurons, these actions on their processing of transient and rapidly rising (i.e. dynamic) inputs are poorly understood. We propose systematic study of this issue. Our results will be essential for understanding the genesis of rapid movements and the use of transient inputs to identify functional connections in humans in both normal and pathological states.

PI_NAMEs: HECKMAN, CHARLES  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Action Potentials;Affect;Animals;Axon;Behavior;Brain Stem;Cephalic;Custom;Data;Dendrites;driving force;Electrodes;experimental study;Felis catus;Foundations;Goals;H-Reflex;Human;In Situ;Link;Location;Locomotion;Magnetism;Measures;Mediating;metaplastic cell transformation;Modeling;Motor;motor behavior;Motor Neurons;Motor output;Movement;Muscle;Nervous System Disorder;Nervous System Trauma;neural;Neurons;neuroregulation;Norepinephrine;Output;Pathologic;Pattern;Population;postsynaptic;Preparation;Probability;Property;recruit;Resistance;Role;sensorimotor system;Serotonin;Source;Speed;Spinal;Spinal Injuries;Stimulus;supercomputer;Synapses;Synaptic Potentials;System;Testing;Uncertainty;voltage;Voltage-Clamp Technics

PROJECT_TITLE: Neuromodulation of motoneuronal processing of dynamic synaptic inputs

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Vascular dementia is the second leading cause of dementia and can occur as a result of ischemic stroke. To develop therapeutics for post-stroke and vascular dementia, cellular and molecular mechanisms underlying age-related differences in stroke progression and recovery must be elucidated. This project aims to examine age-related differences in T cell trafficking and accumulation in the post-stroke brain, as it correlates with stroke-mediated cognitive impairments.

PI_NAMEs: JUNG, YOO JIN (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Acute;acute stroke;adaptive immune response;Affect;Age;age difference;age related;age related changes;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Antigens;Bioenergetics;Biological Assay;Blood Vessels;Brain;Brain Ischemia;cell age;Cell Physiology;Cells;Cellular Metabolic Process;Cellular Structures;Characteristics;Chemotaxis;Chronic;chronic stroke;Citric Acid Cycle;Classification;Clonal Expansion;Cognition;Cognitive deficits;cytokine;Data;Dementia;Distal;Elderly;Exhibits;experience;Genes;Genus Hippocampus;Glycolysis;Immune;immune activation;immune function;Immune response;Immune Response Genes;Immune signaling;Immune Targeting;Immunity;immunogenic;Impaired cognition;Impairment;improved;Individual;Infiltration;Inflammaging;Inflammatory;Inflammatory Response;inhibitor;Innate Immune Response;Ischemia;Ischemic Stroke;Measurement;Measures;Mediating;Metabolism;metabolomics;Middle Cerebral Artery Occlusion;Mitochondria;Molecular;mouse model;Mus;Myeloid Cells;Natural Immunity;Nature;neurotoxicity;novel therapeutics;old mice;older patient;Operative Surgical Procedures;Pentosephosphate Pathway;Peptides;Perfusion;Peripheral;Phase;post stroke;post stroke cognitive impairment;post stroke dementia;Proliferating;receptor;Recovery;Recovery of Function;Research Proposals;response;Risk;Risk Factors;Role;Stroke;stroke outcome;stroke patient;systemic inflammatory response;T cell clonality;T cell infiltration;T cell response;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;trafficking;Up-Regulation;Vascular Dementia

PROJECT_TITLE: Characterizing age-related differences in T cell responses to stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: PROJECT NARRATIVE “Protein Lipidation: Enzymology, Signaling and Therapeutics” will be held from July 21st – July 24th, 2024 at Loews Ventana Canyon in Tucson, Arizona. Protein lipidation, a prevalent post-translational modification of proteins involving lipid attachment, holds profound significance in human diseases. This conference will bring together researchers from diverse fields related to protein lipidation, fostering knowledge exchange and collaborations to understand its biology and develop effective treatments for these diseases, all while fostering the development of the next generation of diverse protein lipidation researchers.

PI_NAMEs: DICKINSON, BRYAN  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Acylation;age-related disease;Area;Arizona;Attention;Biochemistry;Biology;Biophysics;Biotechnology;Cancer Biology;cancer cell;career;career development;catalyst;Cell Physiology;Cells;Cellular biology;Chemicals;Child Care;Collaborations;college;Communicable Diseases;Communities;Dedications;Development;Discipline;Disease;drug discovery;effective therapy;Elevator;empowerment;Ensure;Environment;Enzymatic Biochemistry;Enzymes;Equilibrium;Equity;equity, diversity, and inclusion;Event;Faculty;Fostering;Foundations;Funding;Future;graduate student;Grant;human disease;immune function;innovation;insight;interdisciplinary collaboration;interest;International;Knowledge;lecturer;Letters;lipid transport;Lipids;Malignant Neoplasms;medical schools;meetings;Membrane;Mentorship;Methodological Studies;Microbiology;Modification;Molecular;Monomeric GTP-Binding Proteins;Nervous System Disorder;Neurobiology;new technology;next generation;novel;Pathway interactions;Physiological Processes;Physiology;Play;Post-Translational Protein Processing;Postdoctoral Fellow;posters;prenylation;Process;programs;Proteins;Proteomics;Regulation;Research;Research Personnel;rho;Role;Science;Scientist;Series;Shapes;sharing platform;Signal Transduction;structural biology;Students;summer research;symposium;Technology;technology development;Therapeutic;therapeutic target;Time;tool;trafficking;translational study;Travel;Underrepresented Populations;Wisconsin;Woman

PROJECT_TITLE: Protein Lipidation: Enzymology, Signaling, Therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Project Narrative  New approaches are needed to mitigate and treat osteoarthritis, a debilitating disease involving a progressive erosion of the cartilage tissue, and one that lacks an effective treatment option barring a total surgical replacement of the joint. Emerging research shows that biomechanical loading of the joint can be an effective mitigation strategy of osteoarthritis and can accelerate the production of biomedically engineered cartilage tissue, yet how such loading processes result in improvements in the joint health remains unclear. The proposed research will establish the fundamental mechanism by which biomechanical loading stimulates the cells in the joints to facilitate the growth and repair of cartilage tissue, which will advance clinical treatment of osteoarthritis and drive the innovation of new therapies based on mechanical loading of tissues in the body.

PI_NAMEs: SONG, HYUK JOON JAKE (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Acceleration;Address;Affect;Alginates;Apoptosis;Biochemical;Biocompatible Materials;Biological;Biological Assay;Biomechanics;Biomedical Engineering;Biophysical Process;Biophysics;Biopolymers;Calcium;cancer cell;career;Cartilage;Cartilage Diseases;Cartilage Matrix;cartilage regeneration;cartilage repair;Cattle;Cell membrane;cell motility;Cell Physiology;Cell Volumes;Cells;Chondrocytes;Clinical Treatment;Consensus;Cytoskeleton;Defect;Degenerative polyarthritis;Devices;Disease;effective therapy;Environment;experience;Extracellular Matrix;Future;Gel;Gene Expression;Genes;Growth;Health;Homeostasis;Human;Hydrogels;Image;improved;in vivo;innovation;insight;Ion Channel;joint loading;Joints;Measurement;mechanical force;mechanical load;mechanical properties;Mechanical Stress;Mechanics;mechanotransduction;Medical;Medical Research;Metabolic;Metabolism;Methods;Microscope;Moderate Exercise;Molecular;Movement;novel strategies;novel therapeutics;Operative Surgical Procedures;Osmotic Pressure;Pathway interactions;Patients;Physics;Physiological;Physiology;Polymers;Process;Production;Proliferating;Property;Protocols documentation;Recommendation;Regulation;Relaxation;Replacement Arthroplasty;Research;Research Personnel;response;Role;Seminal;Signal Pathway;stem cell differentiation;Stress;Structure;System;Techniques;Testing;Tissue Engineering;Tissues;Training;treatment strategy;Universities;viscoelasticity;Weight-Bearing state;Work

PROJECT_TITLE: Enhanced cartilage formation of chondrocytes in viscoelastic ECMs under mechanical loading

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Transgender and gender-diverse (TGD) individuals in the United States face substantial stigma, prejudice, and health disparities that may be mitigated by gender-affirming care, but little is known about resilience factors to support TGD health in the years after gender-affirming surgery. Access to healthcare is a proposed element of TGD resilience, but many TGD people are likely to avoid or delay care due to stigma, and existing research about TGD access to care is lacking both rich description and a focus on the crucial period after gender- affirming surgery. To inform future interventions for TGD health equity across the lifespan, the proposed study will leverage an existing study of TGD individuals after gender-affirming surgery to characterize their access to care through “personal healthcare networks” of healthcare professionals, analyze associations between these networks and physical and mental health, and qualitatively explore their experiences of navigating stigma and minority stress in building and accessing these networks.

PI_NAMEs: GAEDECKE, TYLER  (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: acute care;Address;Adult;Affect;Anxiety;Appearance;Area;Award;Binding;career;Caring;Characteristics;Chronic;Chronic Disease;Chronic stress;cisgender;Clinical;cohort;Complex;Cross-Sectional Studies;Data;Data Collection;Discrimination;Disease Management;Disparity;disparity reduction;Elements;Environment;experience;Face;Feeling suicidal;Fostering;Fright;Future;Gender;gender affirming care;gender affirming intervention;Gender Confirmation Surgery;gender diverse;Gender Identity;Genitalia;Health;Health Benefit;health care availability;health care settings;health disparity;health disparity populations;health equity;Health equity research;Health Personnel;Health Professional;Health Services Accessibility;Health system;Healthcare;HIV;improved;Individual;insight;Interdisciplinary Study;interest;Intervention;Interview;Knowledge;Life;Life Cycle Stages;life span;Link;Literature;marginalized population;Measurement;Measures;medical specialties;Mental Depression;Mental Health;Mentors;Mentorship;Methods;minority stress;Modeling;multidisciplinary;Nature;Nurses;Operative Surgical Procedures;Outcome;Parents;Participant;Pathway Analysis;patient oriented;Patients;Persons;physical conditioning;Population;Postoperative Period;Prejudice;Preventive screening;Procedures;Process;prospective;Provider;psychological distress;recruit;Research;Research Personnel;resilience;resilience factor;Role;Sampling;School Nursing;Scientist;Sex Characteristics;social;Social Network;social stigma;Social support;Sociology;Structure;Subgroup;substance use;Suicide attempt;Surveys;System;Testing;Training;transgender;United States;Universities

PROJECT_TITLE: Personal Healthcare Networks of Transgender and Gender-Diverse Adults After Gender-Affirming Surgery

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (88)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Wound Healing and Care

ORG_DEPT: SURGERY

PHR: Project Narrative Interventions to improve the outcome of corneal transplantation are urgently needed for patients that are at high- risk of graft failure. This project aims to translate the basic findings with MG53 into a potential safe and effective therapeutic to improve the quality of corneal transplants and reduce graft failures.

PI_NAMEs: CHANDLER, HEATHER ;MA, JIANJIE  (contact);SHARMA, AJAY

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Ablation;Address;Alkalies;Allografting;Anti-Inflammatory Agents;Aqueous Humor;Bandage;Beds;Benefits and Risks;Blood Circulation;Cell membrane;Cell Physiology;Cellular Structures;Chronic;Circulation;Cornea;corneal epithelium;Corneal Injury;corneal regeneration;Custom;Data;Environment;epithelium regeneration;Exhibits;Eye;Eyedrops;Fibroblasts;Fibrosis;Film;Formulation;Freeze Drying;gain of function;Gel;Goblet Cells;graft failure;Graft Rejection;healing;Health;high risk;Homeostasis;Human;Immunosuppressive Agents;improved;improved outcome;Inbred BALB C Mice;Infection;Infiltration;Inflammation;Inflammatory;Injury;Intervention;Keratoplasty;Knock-out;limbal;loss of function;Maintenance;manufacturing scale-up;member;Molecular;mouse model;Multicellular Process;Mus;Muscle;Muscle Cells;Myofibroblast;Natural regeneration;Outcome;Patients;Penetration;Phase;Physiological;Powder dose form;Predisposition;preservation;Procedures;Process;Protein Family;Proteins;Quality Control;re-epithelialization;Recombinants;reconstitution;Regenerative capacity;repaired;Research Design;Resistance;response;Risk;Rodent Model;Role;Signal Transduction;stem cell function;stem cells;success;Symptoms;Therapeutic;Therapeutic Agents;therapeutically effective;tissue injury;tissue regeneration;tissue repair;Tissues;Topical application;transdifferentiation;Transforming Growth Factor beta;Transgenic Mice;Translating;Transplant Recipients;Transplantation;Treatment Efficacy;TRIM Gene;Vascularization;Vesicants;Work;wound healing

PROJECT_TITLE: Targeting the multicellular process of corneal regeneration and vascularization to enhance outcome of cornea transplantation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative In this study, I will determine the cell-autonomous and non-autonomous roles of the P/Q-type channel, a voltage- gated calcium channel associated with CACNA1A-related neurological disorders including ataxia, epilepsy, and intellectual disability, in oligodendrocyte lineage cells (OLCs), the myelinating glia of the central nervous system. To do this, I will use cell-specific and global CRISPR/Cas9 mutagenesis, in vivo imaging of transgenic zebrafish, motor assays, and a newly developed protocol to perform whole-cell patch-clamp electrophysiology in zebrafish spinal cord OLCs. Together, these experiments will provide new insight into the signaling properties of developing OLCs and the role of OLCs in CACNA1A-related disorders, which may uncover new therapeutic targets.

PI_NAMEs: PILLER, MELANIE ELAINE (contact)

PROJECT_TERMS: Agonist;antagonist;Ataxia;Axon;Biological Assay;Biological Models;Biological Process;Brain;Calcium;Calcium Channel;Calcium Signaling;Calcium-Activated Potassium Channel;Cell Lineage;Cell Physiology;Cells;Cellular biology;Central Nervous System;Cessation of life;comparison control;CRISPR/Cas technology;Data;Demyelinations;Development;Disease;disease-causing mutation;Electrophysiology (science);Epilepsy;Episodic ataxia;experimental study;fluorescence imaging;Foundations;Functional disorder;Future;Genes;genetic approach;Genetic Transcription;Human;human disease;human model;Image;Impairment;in vivo imaging;insight;Intellectual functioning disability;Ion Channel;L-Type Calcium Channels;Literature;Measures;Mediating;Methods;Modeling;Motor;Mutagenesis;mutant;Mutate;Mutation;Myelin;myelination;nervous system development;Nervous System Disorder;Neuroglia;Neurons;Neurophysiology - biologic function;neurotransmission;new therapeutic target;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;P-Q type voltage-dependent calcium channel;patch clamp;Pathology;Patients;pharmacologic;Phenotype;Potassium;Potassium Channel;Production;Proliferating;Property;Protocols documentation;response;Role;Signal Transduction;Spinal Cord;stem cells;System;Testing;trafficking;transgene expression;Transgenes;Transgenic Organisms;transmission process;Vesicle;voltage;voltage clamp;voltage gated channel;white matter;Work;Zebrafish

PROJECT_TITLE: The role of P/Q-type channels in oligodendrocyte lineage cell development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is a common neurodegenerative disorder that affects every 1 in 9 Americans aged 65 and older. Mounting evidence links dysfunctional brain perineuronal nets (PNNs) and their sulfated glycosaminoglycans (GAGs) as an underlying driver of AD progression through the promotion of neurocircuit destabilization. The goal of this proposal is to determine novel mechanisms linking changes in brain PNN glycans sulfation patterning with neuroinflammation and loss of stable PNN matrices inherent to AD, thus providing a novel foundation upon which new targets and therapies for AD can be developed and tested.

PI_NAMEs: MEURET, CRISTIANA JOY (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: abeta deposition;Address;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease therapy;American;Area;Astrocytes;astrogliosis;Automobile Driving;Biological;Biological Process;Brain;brain dysfunction;Brain region;brain tissue;cell type;Cells;Chondroitin Sulfates;Clinical;Cognition;Contralateral;Data;demented;Dementia;Deposition;Dermatan Sulfate;dermatan sulfate chondroitin sulfate;Development;Disease;disease mechanisms study;Disease Progression;Extracellular Matrix;Fellowship;Foundations;Functional disorder;Glial Fibrillary Acidic Protein;Gliosis;Glutamates;Glycosaminoglycans;Goals;Hippocampus;Human;human disease;human old age (65+);Hybrids;hyperphosphorylated tau;Image;imaging capabilities;Impaired cognition;innovation;Investigation;Ipsilateral;Isomerism;Label;Learning;Link;mass spectrometric imaging;Memory;Methodology;Modeling;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuroinflammation;Neurons;neuropathology;new therapeutic target;non-demented;novel;overexpression;Pathogenesis;Pathogenicity;Pathology;Patients;Pattern;Polysaccharides;polysulfated glycosaminoglycan;Process;Reporting;Research Personnel;restoration;Role;Side;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Structure;Sulfate;sulfotransferase;Tauopathies;Techniques;Testing;Therapeutic;therapeutic target;Viral

PROJECT_TITLE: Deciphering the Role of Glycan Sulfation in Neuroinflammation and Alzheimer's Disease


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CHAPEL HILL

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will reveal information about biochemical mechanisms that modify clot formation, stability in individuals with congenital factor XI (FXI) deficiency, and expand the medical knowledge base to reduce the burden of human disease. Successful completion of the proposed aims may lead to clinical assays that predict bleeding in FXI-deficient individuals. Our findings may also have clinical impact by leading to new methods for selecting patients most likely to benefit from use of FXI antagonists to prevent thrombosis.

PI_NAMEs: LEIDERMAN, KARIN ;WOLBERG, ALISA S. (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: antagonist;Antigens;autosome;Biochemical;Biological Assay;Biology;Blood Coagulation Factor;Blood Platelets;Cerebral hemisphere hemorrhage;Clinical;clinical care;Clinical Trials;Coagulation Process;cohort;Computer Models;Computing Methodologies;Contact Inhibition;Data;Detection;Disease;enhancing factor;evidence base;experience;Experimental Models;experimental study;Factor XI;Factor XI Deficiency;Family;Fibrinolysis;Generations;Genetic Determinism;genetic variant;Goals;Hemorrhage;Hemostatic Agents;Hemostatic function;human disease;improved;in silico;In Vitro;in vitro Assay;in vitro Model;Individual;Injury;innovation;interdisciplinary approach;knowledge base;Laboratories;lipidomics;Machine Learning;Masks;Mass Spectrum Analysis;Medical;Menorrhagia;metabolomics;Methods;Modeling;Molecular;morphogens;mouse model;multiple omics;Mutation;Nose;novel;Oral cavity;overtreatment;Pathway interactions;Patient Selection;Patients;personalized medicine;Persons;pharmacologic;Phenotype;Plasma;Plasma Proteins;Positioning Attribute;predictive modeling;predictive test;Predisposition;prevent;Prevention;prophylactic;Prophylactic treatment;Proteins;Proteomics;Public Health;Research;research clinical testing;Risk;Sampling;Site;Structure;synergism;Testing;Thrombin;Thromboplastin;Thrombosis;tool;Training;Translating;urogenital tract;Work

PROJECT_TITLE: Interdisciplinary approach to elucidate modifiers of bleeding phenotype in factor XI deficiency

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-D (02)]


ADMINISTERING_IC: OH

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Our collaborative series of research-to-practice (r2p) conference meetings will advance awareness, utilization and study of correctional worker mental health and well-being resources to reduce stress and trauma that contribute to chronic health issues among this high-risk workforce. They are based on our past symposia design that complimented national corrections organization events and were informed by a national, collaborative taskforce of key informants on correctional workplaces, lived experience, research, and union advocacy. Bridging findings from our recent national prison and jail survey and scoping review to address the usefulness and helpfulness of current and evidence-based practices will inform the quality of resources and dissemination of best practices to correctional workplaces and users.

PI_NAMEs: BELLO KOTTENSTETTE, JENNIFER ;CHERNIACK, MARTIN G;EL GHAZIRI, MAZEN ;JAEGERS, LISA  (contact);VAUGHN, MICHAEL G.

PROGRAM_OFFICER_NAME: LIOCE, MARIA

PROJECT_TITLE: Translating research to practice in corrections staff mental health through dissemination of evidence: from pilots to practical programs

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


NIH_SPENDING_CATS: Genetics;Infant Mortality;Lung;Neurosciences;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Sleep Research;Sudden Infant Death Syndrome

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Sudden Infant Death Syndrome (SIDS) remains the leading cause of infant death in infants less than one year of age and its etiology remains vastly unknown. Mu opioid receptors (MORs) play a crucial role in respiratory regulation and recently a case study identified that a mutation in the OPRM1 gene that encodes a truncated splice variant of MORs was associated with SIDS, suggesting that this gene may be implicated as a risk factor for SIDS etiology. We aim to determine the requirement of the OPRM1 gene and its 6 transmembrane MOR splice variants in the neonatal autoresuscitation reflex, hypothesized to be a common endpoint for many SIDS cases, and respiratory dynamics by utilizing OPRM1 knockout mouse models to uncover molecular targets contributing to SIDS pathology and potential markers for therapeutic intervention.

PI_NAMEs: MEMOS, NICOLETTA K (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: 1 year old;Address;Affect;Age;Air;Anoxia;Blood;Brain;Brain Stem;Breathing;Carbon Dioxide;Case Study;Cell Nucleus;Cessation of life;Congenital Disorders;congenital respiratory disorder;course development;critical developmental period;Development;Developmental Anatomy;Diagnostic;diagnostic development;Disease;Educational workshop;Environment;environmental enrichment for laboratory animals;Esthesia;Etiology;Exclusion;Exons;Exposure to;Face;Failure;Foundations;Functional disorder;Gases;Gene Expression;gene function;Genes;Genetic;genetic risk factor;genetic variant;Goals;heart function;high risk infant;Hypercapnia;Hypoxia;In Vitro;Infant;Infant Mortality;insight;Investigation;Knock-out;knockout gene;Knockout Mice;Length;Literature;loss of function;Membrane;Modeling;Molecular Target;mouse model;mu opioid receptors;Mus;Mutation;Neonatal;Neonatal Abstinence Syndrome;neonatal mice;neonatal respiration;neonate;Neurons;neurotransmission;Nociception;Nucleotides;Opioid;opioid overdose;Opioid Receptor;opioid use;Outcome;Oxygen;Pathogenicity;Pathology;Pattern;Play;Point Mutation;preBotzinger complex;prenatal exposure;Process;Receptor Signaling;Reflex action;Regulation;Reporting;Research;Respiration;Respiration Disorders;respiratory;Respiratory Center;respiratory reflex;response;Risk;Risk Factors;RNA Splicing;Role;Sensory;Signal Transduction;sleep position;Spices;Spliced Genes;stressor;Structure;Sudden infant death syndrome;targeted treatment;Technology;Testing;therapeutic biomarker;therapeutic development;Therapeutic Intervention;Tissues;Training;transcriptomics;Variant;variant of unknown significance;Ventilatory Depression;Work

PROJECT_TITLE: Mu Opioid Receptors and Splice Variant Expression in Neonate Autoresuscitation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


NIH_SPENDING_CATS: Arthritis;Congenital Structural Anomalies;Genetics;Osteoarthritis;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Articular cartilage degradation and ossification are hallmarks of osteoarthritis, a highly prevalent joint disorder that severely impacts quality of life. The proposed project uses high-throughput screening and machine learning to characterize how articular cartilage chondrocytes establish their identity during embryonic development. Ultimately, we aim to identify proteins that can generate chondrocytes from other cell types as a treatment for osteoarthritis.

PI_NAMEs: ONGGO, SHARON  (contact)

PROJECT_TERMS: Acetaminophen;Address;Adrenal Cortex Hormones;Adult;Affect;Arthritis;arthropathies;articular cartilage;Binding;bone;Bone Development;cartilage cell;cartilage degradation;Cartilage Matrix;Cell Cycle;Cell Nucleus;cell type;Cells;Chondrocytes;Chromatin;daily functioning;Data;Defect;Degenerative polyarthritis;Development;disability;Elements;Embryonic Development;Epigenetic Process;Epiphysial cartilage;Equilibrium;Exhibits;Future;gene regulatory network;Genes;Genetic Transcription;Growth and Development function;Hand;high throughput screening;Hip region structure;Hyaline Cartilage;Hypertrophy;In Vitro;Injections;insight;Joint by Site;joint formation;joint loading;Joints;jun Oncogene;Knee;Limb Development;Limb structure;Link;Machine Learning;Maintenance;Mental Depression;Mesenchymal;Modeling;multiple omics;Multipotent Stem Cells;Mus;Non-Steroidal Anti-Inflammatory Agents;novel;Osteogenesis;overexpression;Pain;Pain management;Pathologic;Pathway Analysis;permissiveness;Phenotype;Physiologic Ossification;Population;Process;progenitor;programs;promoter;Property;prospective;Proteins;Quality of life;reduce symptoms;Regenerative capacity;Regulation;Regulon;repaired;Role;single-cell RNA sequencing;Site;skeletal;SOX4 gene;stem cell differentiation;stem cell fate;stem cells;Structure;Swelling;Synovial joint;Testing;therapeutic target;Thick;transcription factor;transcriptome;Traumatic injury;United States;WNT9A gene

PROJECT_TITLE: Novel transcriptional regulators of synovial joint and bone development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: MADISON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative  Primordial germ cells (PGCs), the precursors to sperm and egg, undergo global epigenetic remodeling including erasure of repressive histone modifications, such as H3K9me2 and DNA methylation. Improper retention of these epigenetic modifications could compromise germ cell development and lead to transgenerational epigenetic inheritance. In this proposal I will investigate how the H3K9me2 demethylases, KDM3A and KDM3B, regulate epigenetic remodeling in PGCs, which has important implications for reproductive biology and medicine.

PI_NAMEs: CORMATY, HARSHINI  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Alleles;Binding;Cell Count;Cell Differentiation process;Cell division;Cell Line;Cell model;Cell Reprogramming;Cells;conditional knockout;Data;data integration;Defect;demethylation;Development;DNA;DNA Methylation;DNA Modification Methylases;DNA Transposable Elements;Dot Immunoblotting;Down-Regulation;egg;Embryo;Embryonic Development;embryonic stem cell;Enzymes;Epiblast;Epigenetic Process;epigenome;Excision;experimental study;Female;Fertility;Fertility Disorders;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genomic Instability;genomic locus;Germ Cells;Germ Lines;Heterochromatin;histone demethylase;histone methylation;histone modification;Histones;Immunofluorescence Immunologic;implantation;imprint;In Vitro;in vitro Model;induced pluripotent stem cell;Investigation;Knock-out;Knockout Mice;Location;Lysine;male;Modeling;Modification;mouse development;Mouse Embryonic Stem Cells;Mus;next generation sequencing;non-genetic;Oocytes;Phase;Phenotype;pluripotency;Post-Transcriptional Regulation;prevent;Proteins;Repression;reproductive;Reproductive Biology;Reproductive Medicine;Research;Role;Somatic Cell;Specific qualifier value;sperm cell;Spermatogenesis;Sterility;Structure of primordial sex cell;System;Time;Tissues;tool;transcription factor;transcriptome sequencing;transgenerational epigenetic inheritance;transmission process

PROJECT_TITLE: Histone demethylase control of primordial germ cell specification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-L (20)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative:  Marked depletion of essential micronutrients such as iron perturbs the gut microbiota during intestinal inflammation, depleting beneficial commensal bacteria. Despite being central to maintaining the overall microbiota structure and function in the face of perturbations, the mechanisms underlying commensal resilience remain poorly understood. This project investigates how the prevalent gut bacterium Bacteroides thetaiotaomicron survives iron starvation during enteric pathogen infection, thereby providing a crucial understanding of commensal resilience mechanisms and iron competition in the inflamed gut.

PI_NAMEs: FANSLER, RYAN T (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Affinity;Bacteria;Bacteroides;Bacteroides thetaiotaomicron;Binding;Biochemical;Biological Assay;Cell Physiology;clinically relevant;Colitis;colonization resistance;combat;commensal bacteria;Couples;Coupling;Data;design;Disease;Disease Outcome;dysbiosis;Ecosystem;effective therapy;enteric infection;enteric pathogen;Expenditure;experimental study;extracellular;fitness;Genetic;Growth;gut bacteria;gut inflammation;gut microbiome;gut microbiota;Health;Homeostasis;Human;Immune system;In Vitro;in vivo;Individual;Infection;Infectious colitis;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;insight;Intestines;Invaded;Iron;Iron Chelating Agents;Iron Chelation;iron metabolism;kinetic model;Knowledge;LCN2 gene;Life;Lipoproteins;Mediating;Membrane;Microbe;microbial;microbiome composition;microbiota;Micronutrients;model organism;Modeling;Molecular;mouse model;mutant;novel;Nutrient;Nutritional;Nutritional Immunity;Outcome;pathogen;Play;Predisposition;Process;Protein Secretion;Proteins;Regulation;Research;resilience;response;Role;Salmonella typhimurium;Shapes;Siderophores;Signal Transduction;small molecule;Small RNA;Starvation;Stress;Structure;Testing;Therapeutic;therapeutic target;Time;uptake;Vesicle;Work

PROJECT_TITLE: Iron homeostasis in sustaining commensal resilience in the inflamed gut


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project is expected to broadly impact the massive public health problems of obesity and chronic pain. This research will identify neurotensin circuits that act via the ventral tegmental area of the brain to modulate feeding behaviors and the perception of pain. The identified endogenous analgesic mechanism may be leveraged to treat comorbid obesity and pain safely and simultaneously.

PI_NAMEs: LEINNINGER, GINA MARIE (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Absence of pain sensation;Address;Affinity;Agonist;American;Analgesics;Appetite Depressants;Astrocytes;Body Weight;Body Weight decreased;Brain;cell type;Cells;chronic pain;combat;comorbidity;Data;Dependence;design;Development;diet-induced obesity;effective therapy;energy balance;feeding;Feeding behaviors;Funding;Health Care Costs;Hypothalamic structure;Impairment;improved;Individual;Knowledge;Lateral;Lateral Hypothalamic Area;Mediating;Modeling;Mus;Neurobiology;Neurons;Neuropeptides;Neurosciences;Neurotensin;Neurotensin Receptors;neurotransmission;non-opioid analgesic;Obese Mice;Obesity;obesity treatment;Opioid;opioid epidemic;optogenetics;Outcome;Pain;pain perception;pain relief;Pathway interactions;prevent;Protein Isoforms;Public Health;Publishing;receptor;recombinase;Research;restraint;Risk;Role;sensor;Signal Transduction;Source;System;Testing;Thinking;treatment strategy;Ventral Striatum;Ventral Tegmental Area;Weight;Weight Gain

PROJECT_TITLE: Role of Lateral Hypothalamic Neurotensin Neurons in Energy Balance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-B (02)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Chagas disease is responsible for a considerable number of cases of cardiomyopathy, heart failure, and sudden cardiac death in the Latin American population. This work aims to better understand the mechanisms that mediate the progression towards these cardiac manifestations of disease that occur in 20-30% of individuals infected with the causal parasite. This project will focus on investigating the spatiotemporal alterations in the immune response that are associated with cardiac damage and will evaluate the therapeutic value of depleting B cells in a murine model of disease.

PI_NAMEs: DUQUE, CAROLINA  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Anatomy;Antibody Formation;Antigen Presentation;Apoptosis;Arrhythmia;Autoantibodies;Autoimmune Responses;B-Lymphocytes;Biological;biomarker identification;C57BL/6 Mouse;Cardiac;Cardiomyopathies;Cell Physiology;cell type;Cells;Cessation of life;Chagas Disease;chagasic cardiomyopathy;Chronic;climate change;Collection;Complement;Complement Activation;cytokine;Data;Deposition;Development;Diagnosis;differential expression;Dilated Cardiomyopathy;Disease;disease model;Disease Progression;Echocardiography;effective therapy;Electrocardiogram;experimental study;Fibrosis;Flow Cytometry;follow-up;Gene Expression;Genes;Heart;heart damage;Heart Diseases;Heart failure;heart function;Heart Transplantation;high risk;high throughput analysis;High-Throughput Nucleotide Sequencing;Human;Immune;immune cell infiltrate;Immune response;Immune System Diseases;Immunofluorescence Immunologic;Immunologics;Immunotherapy;improved;Individual;ineffective therapies;Infection;Inflammatory;inflammatory marker;Inflammatory Response;Latin American;Longitudinal cohort;Longitudinal Studies;Maps;Mediating;Methods;migration;mouse model;Nature;Necrosis;novel;Parasites;Pathogenesis;Pathology;Pathway interactions;patient stratification;Patients;Pattern;Peripheral Blood Mononuclear Cell;persistent symptom;personalized intervention;Play;Population;prevent;Prevention;Process;Production;progression marker;Pulmonary Embolism;Resolution;response;risk stratification;Role;sample collection;Sampling;Signal Pathway;Signal Transduction;Signs and Symptoms;single-cell RNA sequencing;Source;spatiotemporal;Stroke;sudden cardiac death;Techniques;Therapeutic;therapeutic target;Time;Tissues;tositumomab;Transcript;transcriptomics;Transplant Recipients;treatment strategy;Trypanosoma cruzi;Work

PROJECT_TITLE: Deciphering the immunologic landscape of Chagas cardiomyopathy pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Disruptions of striatal dopamine transmission underlie numerous neuropsychiatric diseases and substance abuse disorders. Yet, much is still unknown about how dopamine transmission is structured at the subcellular level under healthy and diseased conditions. In this proposal, I will determine how different modes of dopamine transmission are regulated and identify how these different modes contribute to reward related behaviors.

PI_NAMEs: MCGREGOR, MATTHEW M (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Address;Affect;Axon;Behavior;Behavioral;Behavioral Assay;Belief;Biological Assay;Characteristics;Clustered Regularly Interspaced Short Palindromic Repeats;conditioned place preference;Corpus striatum structure;Coupled;Data;Decision Making;Disease;Dopamine;Dopamine D2 Receptor;dopamine transporter;dopaminergic neuron;Electrophysiology (science);Enzymes;experimental study;Fiber;fluorescence imaging;Functional disorder;G protein-coupled inwardly-rectifying potassium channel;Genetic;Goals;Health;Impairment;innovation;knock-down;Knock-out;Learning;Light;Link;Measurement;Measures;Mediating;Mental disorders;meter;Methodology;Methods;Microdialysis;millisecond;Modeling;Motivation;Neurons;neuropsychiatric disorder;Nucleus Accumbens;optogenetics;Outcome;overexpression;Periodicity;pharmacologic;Photometry;Play;postsynaptic;presynaptic;Probability;Property;Radial;reinforced behavior;Resolution;reuptake;Rewards;Role;Running;Scaffolding Protein;Scanning;Self Administration;sensor;Shapes;Signal Transduction;Site;Slice;spatiotemporal;Stimulus;Structure;Substance abuse problem;Synapses;Synaptic Receptors;Synaptic Transmission;Techniques;Testing;transmission process;Tyrosine 3-Monooxygenase;Varicosity;Viral;Work

PROJECT_TITLE: Dissecting Modes of Dopamine Transmission and Their Roles in Reward Related Behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Microbiome;Nutrition;Urologic Diseases

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE Higher urine oxalate (UOx) can lead to calcium oxalate kidney stones and chronic kidney disease incidence and progression. The gut microbiome plays a key role in human oxalate homeostasis and is different in stone formers and non-stone formers. This translational approach combining mechanistic murine models and patient-centered studies will identify the role of the microbiome and other host related factors in determining UOx.

PI_NAMEs: CURHAN, GARY C.;LI, HUILIN ;NAZZAL, LAMA  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: absorption;Address;Adult;Adverse effects;Affect;Animal Model;Animals;Bacteria;bacterial community;Bifidobacterium;Calcium Oxalate;Cells;Chronic Kidney Failure;clinically significant;Colon;comorbidity;Computer Models;Data;Data Analyses;Data Set;Diet;dietary;Energy-Generating Resources;Enzymes;Escherichia coli;Excretory function;experimental study;Follow-Up Studies;formyl-coenzyme A transferase;Functional disorder;Genes;Genetic;genomic data;Goals;gut microbiome;gut microbiota;Health Professional;Homeostasis;Hour;Human;human data;Human Microbiome;Hyperoxaluria;in vivo;Incidence;Integration Host Factors;Intestinal Absorption;Intestines;Investigation;Kidney Calculi;Kidney Diseases;Knowledge;Lactobacillus;Link;Mammals;Measures;member;men;Metabolism;metagenome;Metagenomics;metatranscriptome;metatranscriptomics;microbial;microbiome;Modeling;mouse model;multidisciplinary;Mus;Nurses' Health Study;Organism;Oxalates;Oxalobacter formigenes;Oxalyl-CoA decarboxylase;Participant;patient oriented;Pharmaceutical Preparations;Play;Population;Population Study;Prevention;Probiotics;Proxy;Public Health;Recording of previous events;Resources;Rodent Model;Role;Source;stool sample;Testing;Therapeutic;therapeutic target;Transcript;translational approach;translational model;urinary;Urine;Woman

PROJECT_TITLE: The role of the microbiome and other host related factors in determining urine oxalate levels

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Tissue-resident memory CD8 T cells (TRM) stably occupy the skin where they rapidly detect pathogen reinfection and initiate protective anamnestic immune responses. My proposed research will identify how skin TRM orchestrate immune cells and influence distal immunity. Defining the potential of TRM following activation in the skin will expand the therapeutic outlook of TRM as targets that can combat skin pathogens.

PI_NAMEs: SMITH, OLIVIA C. (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute;acute infection;Acute-Phase Reaction;Address;Agonist;Animal Model;Anti-viral Response;Antigens;antiviral immunity;Bite;Body System;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Physiology;Cells;Cellular biology;Cellular Immunity;Circulation;Clinical;combat;Communicable Diseases;Complement;Culicidae;Cutaneous;cytokine;Data;Dendritic Cells;Dengue Virus;Disease;Distal;Endocrine;Environment;Gene Expression Profiling;Goals;Hematopoietic;human tissue;Immune;Immune response;Immunity;Immunization;In Situ;Infection;Infectious Skin Diseases;Inflammation;Label;Location;Memory;Mentors;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;novel;novel strategies;Organ;pathogen;Pathogen detection;Pattern;Phase;Physicians;Physiology;Population;Primary Infection;Process;Production;rapid detection;recruit;Research;response;Route;Scientist;Signal Transduction;Site;Skin;Skin Tissue;smallpox eradication;Stimulus;Structure;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;tissue resident memory T cell;Tissues;Training;two photon microscopy;vector-borne;Viral;viral transmission;Virus;Virus Diseases;West Nile virus;Zika Virus

PROJECT_TITLE: Investigating the local and systemic coordination of antiviral immunity by tissue-resident memory CD8 T cells in the skin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Drug Abuse (NIDA only);Mental Health;Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: KINGSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Project Narrative Adolescent substance use is associated with numerous negative health consequences, and there are calls to focus on protective factors that may buffer against adolescent substance use and related consequences prior to the development of more severe outcomes in later life. Adolescents are at a critical developmental period for learning and solidifying protective strategies and behaviors against alcohol and cannabis outcomes (e.g., alcohol use, binge drinking, cannabis use, alcohol-related consequences, cannabis-related consequences), yet there is a dearth of research on the protective mechanisms underlying behavior change over time in adolescents. The proposed study will utilize longitudinal mediation to examine if changes in happiness and pleasurable activities are associated with changes in alcohol and cannabis outcomes over time in adolescents; findings will clarify whether happiness and pleasurable activities are promising targets for future research and prevention efforts.

PI_NAMEs: TRINH, CATHERINE D (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent health;adolescent substance use;Adult;Age;Alcohol consumption;alcohol related consequences;Alcohols;Area;Behavior;behavior change;Behavioral;binge drinking;Buffers;Cannabis;Cognitive;Cohort Studies;Computer software;critical developmental period;Data;Data Analyses;Development;drug abuse prevention;early adolescence;emotion regulation;Emotional;Environment;Ethnic Origin;Exercise;experience;Family;Friends;Funding;Goals;graduate student;Grant;Growth;Happiness;Health;Health Promotion;improved;innovation;insight;Knowledge;late life;Learning;Literature;Manuscripts;marijuana use;Mediating;Mediation;Mediator;Mentorship;Modeling;Morbidity - disease rate;mortality;movie;National Institute of Drug Abuse;next generation;novel;novel strategies;Outcome;Pathway interactions;Pattern;Play;positive emotional state;Prevalence;prevent;Prevention;protective factors;psychologic;Race;reduced substance use;Research;Research Personnel;resilience factor;Resources;Rhode Island;Risk Factors;Sampling;Scientist;skills;Sports;substance use;Substance Use Disorder;substance use prevention;Testing;Theoretical model;theories;Time;time use;Training;Underrepresented Students;Universities;Work;young adult

PROJECT_TITLE: Happiness and Pleasurable Activities as Longitudinal Predictors of Adolescent Alcohol and Cannabis Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Safe and effective gene upregulation approaches in the central nervous system have the potential to treat many neurological diseases, including disorders of genetic haploinsufficiency and neurodegeneration. In the present study, we introduce a novel strategy using antisense oligonucleotides to stimulate protein synthesis and evaluate its applicability to ~40% of genes in the human genome, with a focus on proteins that could protect against neurodegenerative disease. Our findings would introduce a new class of gene-boosting biologics that are widely applicable, effective, and safely administered to the central nervous system.

PI_NAMEs: BOROS, BEN DAVID (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: 3' Untranslated Regions;Affect;Affinity;age-related disease;aging brain;Alleles;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Autophagocytosis;Binding;Binding Sites;Biological Assay;Biological Products;Central Nervous System;Central Nervous System Diseases;Clinical;Clinical Trials;Development;Disease;DNA Sequence;Dose;efficacy evaluation;Elderly;Elements;Environment;experience;frontotemporal lobar dementia amyotrophic lateral sclerosis;Gene Expression;Gene Proteins;gene repression;Gene Targeting;gene therapy;Gene Transfer;Genes;Genetic;Genetic Diseases;Goals;Heterozygote;Human;Human Genome;human induced pluripotent stem cells;Impairment;improved;Individual;induced pluripotent stem cell;Inherited;interest;Libraries;Link;loss of function mutation;Masks;Mediating;Messenger RNA;Methods;Modeling;Motor Neurons;mRNA Stability;mRNA Translation;Mus;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neurodegenerative phenotype;Neuroimmune;Neurologic;neuron loss;neuroprotection;neurotrophic factor;novel strategies;Pathway interactions;Phosphotransferases;Physicians;Post-Transcriptional Regulation;posttranscriptional;Pre-Clinical Model;prevent;Process;Property;Protein Biosynthesis;protein expression;protein function;Proteins;proteostasis;Reaction;Regulation;Regulator Genes;Regulatory Element;Reporter;research clinical testing;RNA;RNA Binding;RNA immunoprecipitation sequencing;RNA-Binding Proteins;Scientist;screening;Signal Transduction;Single-Stranded DNA;Site;SLC2A1 gene;Specificity;Spliced Genes;Stereotyping;success;TANK-binding kinase 1;Technology;Testing;Therapeutic;Training;Transcript;Transcription Repressor;Translational Repression;Translations;Untranslated Regions;Up-Regulation;Viral Genes

PROJECT_TITLE: Boosting protein synthesis using antisense oligonucleotides to treat neurodegeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Diabetes is a major global health problem that results in systemic cardiovascular complications, such as hypertension and increased arterial stiffness, and there is evidence that suggests treatment of the diabetes itself can reverse the cardiovascular effects. The proposed research will investigate how diabetes affects large arteries like the aorta, whether these changes can be reversed with treatment to recover glycemic control, and the mechanisms behind these processes. This work will therefore describe how aorta biomechanics and mechanobiology change due to diabetes and its treatment, providing critical information for the understanding of how cardiovascular disease manifests and can be addressed in diabetic patients.

PI_NAMEs: FLANARY, SHANNON M (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: absorption;Address;Advanced Glycosylation End Products;Affect;Aorta;arterial remodeling;arterial stiffness;Arteries;Back;Biomechanics;Blood Glucose;blood glucose regulation;Blood Vessels;Blood Volume;Cardiovascular Diseases;cardiovascular effects;cardiovascular health;Cardiovascular Pathology;cardiovascular risk factor;Cardiovascular system;Cells;Characteristics;Chronic;Clinic;Collagen Fiber;Complement;Computer Models;Coupled;crosslink;Data;Development;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Disease;Disease Progression;Elasticity;Elastin Fiber;Evolution;experimental study;Exposure to;Extracellular Matrix;fibrous protein;Future;global health;Glucose;glycemic control;Goals;Growth;Health;Hyperglycemia;Hypertension;in silico;in vivo;insight;Investigation;lifestyle intervention;Measures;Mechanics;Mediating;Medical;Methodology;Modeling;mouse model;multi-scale modeling;Mus;novel;Pathologic;Phenotype;phenotypic biomarker;Phlorhizin;Physiologic pulse;Process;Pump;Recovery;Research;restoration;Role;Smooth Muscle Myocytes;Specific qualifier value;Testing;therapeutic development;Tissues;Vascular Diseases;Vascular remodeling;Vascular Smooth Muscle;Work

PROJECT_TITLE: Mechanistic Analysis of Aortic Growth and Remodeling due to Hyperglycemia and Recovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Complementary and Integrative Health;Lung;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention

PHR: Project Narrative Asthma is a highly prevalent chronic inflammatory disease of the airways that has been increasingly shown to impact the brain; it is sensitive to changes in stress, often comorbid with anxiety and depression, and has been associated with compromises in brain structure and function. The proposed project seeks to benefit public health by investigating the impact of a Mindfulness Based Stress Reduction intervention on brain health and whole-person health in a population with asthma. We will assess changes in a combination of neuroimaging metrics of brain microstructural integrity, blood-based biomarkers of brain health, asthma symptoms and level of airway inflammation, as well as a host of whole-person health indices such as changes in sleep quality, life stress, and psychological well-being.

PI_NAMEs: CARROL, DANIELLE H (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: aging related disease;Airway Disease;airway inflammation;Anxiety;Asthma;Astrocytes;Axon;axon injury;Behavior Therapy;Biological Markers;blood-based biomarker;Brain;brain health;Chronic;chronic inflammatory disease;Clinical;clinically relevant;comorbid depression;comorbidity;Complement;Data;Data Collection;Dendrites;density;Detection;Deterioration;Diffusion;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;Education;Ethics;Experimental Designs;Fellowship;follow-up;Glial Fibrillary Acidic Protein;gray matter;group intervention;Health;Hippocampus;Image;Impaired cognition;improved;improvement on sleep;indexing;Individual;Inflammation;Inflammatory;Intervention;Life Stress;Light;Link;Literature;Measures;Mediating;Meditation;Mental Depression;Mental disorders;Mental Health;Mentorship;Metabolic;Methods;Mind;mindfulness intervention;Mindfulness Training;mindfulness-based stress reduction;Modeling;Morbidity - disease rate;mortality;myelination;Nerve Degeneration;neural;Neurites;neurofilament;neuroimaging;neuroinflammation;Neurons;Neurosciences;next generation;novel;novel strategies;Outcome;Patient Self-Report;Personal Satisfaction;Persons;physical conditioning;Plasma;poor sleep;Population;post intervention;Prevalence;protective effect;Proteins;psychologic;Psychoneuroimmunology;Public Health;Public Speaking;Randomized;Regulation;Reporting;Resolution;Sampling;Severities;skills;sleep quality;standard care;Statistical Methods;Stress;stress reduction;Structural defect;Structure;Symptoms;systemic inflammatory response;Testing;Tissues;tool;Training;training opportunity;transcription factor;uptake;Waiting Lists;Well in self;white matter;whole health;Work;Writing

PROJECT_TITLE: Whole-Person Health and Brain Health Outcomes of Mindfulness Training in Asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (04)]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Proper spatiotemporal regulation of gene expression and protein abundance plays a crucial role in guiding the differentiation of the fertilized egg into a complex animal and provides valuable insights into germ layer differentiation, specialized cell, and tissue development. However, quantifying lineage-specific protein dynamics in developing embryos is challenging due to technical limitations in single-cell proteomics and the inherent heterogeneity of embryonic tissues, leading researchers to rely on mRNA levels as a proxy despite their limited correlation with protein expression. This proposal aims to decipher embryonic cell-type differentiation mechanisms by utilizing morphogen-flattened embryos and integrating genomics and proteomics analysis, offering valuable insights into transcriptional and posttranscriptional regulation during development.

PI_NAMEs: MARISHTA, ARGIT  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;Animals;Blastoderm;Cell Differentiation process;cell fate specification;Cell Lineage;cell type;Cells;Collection;Communities;Complex;Data;Detection;Development;Developmental Biology;Dorsal;Drosophila genus;Ectoderm;Ectoderm Cell;Embryo;embryo cell;embryo tissue;Embryonic Development;Endoderm;Epidermis;Fertilization;gastrulation;Gene Expression;Gene Expression Regulation;Gene Modified;Gene Proteins;genetic manipulation;Genetic Transcription;Genome;Genomics;Germ Layers;Heterogeneity;Hindgut;Hour;Individual;insight;Isotopes;mathematical model;Measurement;Measures;Mesoderm;Messenger RNA;Methods;morphogens;mRNA Expression;neuroblast;Neuroectoderm;notch protein;Outcome Measure;Pattern;Play;Post-Transcriptional Regulation;posttranscriptional;Process;protein degradation;Protein Dynamics;protein expression;Proteins;Proteome;Proteomics;Proxy;Regenerative Medicine;regenerative tissue;Regulation;Research Personnel;Resources;Ribosomal Proteins;ribosome profiling;Role;single-cell RNA sequencing;smoothened signaling pathway;spatiotemporal;Tissue Engineering;Tissues;tool;Translations;zygote

PROJECT_TITLE: Regulation of protein dynamics in Drosophila embryos' ectoderm germ layer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Mental Health;Methamphetamine;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

PHR: One of the deadliest combinations of drugs used in America today is concurrent opioid and stimulant usage, with polysubstance use responsible for the vast majority of overdose deaths. This project will investigate addiction- like behavioral phenotypes unique to polysubstance use disorders and their underlying neural circuits, using a combination of fentanyl and methamphetamine self-administration and whole brain light sheet microscopy. Together, these findings will provide insight into the neural basis of polysubstance addiction and will have the potential to inform the development of targeted, effective pharmacotherapeutics for the treatment and prevention of polysubstance use disorders.

PI_NAMEs: SAAVEDRA, SARA  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: 3-Dimensional;activity marker;addiction;American;Animals;Autopsy;Behavior;behavior test;Behavioral;behavioral economics;behavioral phenotyping;Biological Assay;Brain;Chronic;cue reactivity;Cues;Decision Making;Development;Disease;drug abstinence;Drug Combinations;Drug Modelings;drug relapse;drug seeking behavior;Drug usage;Drug user;effective therapy;Exposure to;Extinction;Fentanyl;fentanyl seeking;Fluorescent Antibody Technique;FOS gene;Ganglia;Gene Transfer;Goals;Human;Image;Individual;insight;interest;Intravenous infusion procedures;Learning;Light;Maps;Mediating;Methamphetamine;methamphetamine use;Methamphetamine use disorder;Microscopy;Modeling;Molecular;Motivation;multiple drug use;Nervous System;neural;neural circuit;neurobehavioral;Neurobiology;Neuronal Plasticity;Neurons;Neurotransmitters;novel;Opioid;opioid use;opioid use disorder;overdose death;Pattern;Pharmaceutical Preparations;Pharmacologic Actions;polysubstance use;Prevalence;Prevention;Probability;Rattus;receptor;Recording of previous events;recruit;Research;Research Project Grants;response;reward processing;Rewards;Rodent;Rodent Model;Self Administration;Stimulant;stimulant use;Substance Addiction;substance use;Substance Use Disorder;System;Testing;Thalamic structure;Time;Tissues;Treatment outcome;Viral

PROJECT_TITLE: Exploration of the unique neurobehavioral profile of sequential opioid-stimulant polysubstance use disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Benign prostatic hyperplasia (BPH) affects 70% of men over the age of 60, and current interventions are not curative. Stem cell transcription factor SOX2 has been linked to prostate regeneration and BPH, but its role as a potential pharmacologic target has not been established. In the proposed study, we will investigate the role of SOX2 in BPH and define the mechanistic link between SOX2 and IGF signaling; these data will provide new insight into BPH etiology and have high potential to improve current therapeutics for BPH.

PI_NAMEs: VELLKY, JORDAN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: 5 Alpha-Reductase Inhibitor;Address;Adrenergic alpha-Antagonists;Affect;Age;age related;Aging;Basal Cell;Benign;Benign Prostatic Hypertrophy;Biological Models;career;career development;Cell Survival;Cells;Chronic;Clinical;Clinical Trials;clinically relevant;Communication;Cross Reactions;Data;Development;Disease remission;Down-Regulation;Drug Design;drug development;drug repurposing;Drug Screening;Elements;Epithelial Cells;Etiology;experience;experimental study;Fellowship;Frequencies;Functional disorder;Future;Generations;Genetic;Genetic Transcription;Goals;Grant;Healthcare Systems;Human;IGF1 gene;IGF1R gene;improved;In Vitro;in vivo Model;inhibitor;innovation;insight;Insulin;Insulin Receptor;Intervention;Laboratories;Link;loss of function;Lower urinary tract;lower urinary tract symptoms;Mediating;Mediator;men;Mentorship;Metadata;Mining;Modeling;Morbidity - disease rate;mouse model;Multipotent Stem Cells;Natural regeneration;new technology;Nocturia;novel therapeutic intervention;Organ;Pathway interactions;pharmacologic;Physiological;Population;Positioning Attribute;prevent;Prevention;Process;progenitor;Prostate;prostate enlargement;Prostatic;Prostatic Diseases;Proteins;Proteome;psychologic;Publishing;Quality of life;Recurrence;Regenerative pathway;Regulatory Pathway;Research;Research Personnel;Resources;RNA;Role;Scientist;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skills;Small Interfering RNA;Specificity;Specimen;stem;stem cells;success;symptom treatment;Symptoms;Technical Expertise;Technology;Testing;Therapeutic;Therapeutic Effect;Time;Tissues;Toxic effect;Training;Transcript;transcription factor;urinary;Urinary Retention;urologic;Urology;Western Blotting;Writing

PROJECT_TITLE: Targeting SOX2 expression in prostatic regeneration and enlargement

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Kidney, Urology, and Hematology[DDK-G]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PHR: PROJECT NARRATIVE The United States is currently faced with an ever-increasing rate of substance use related deaths which is directly related to individual increased drug consumption. Decreasing general drug consumption, both in amount and frequency, results in less harm to both the user and society as well as illuminates a path towards reducing substance use deaths. This project aims to unveil the role that neuromodulatory systems, specifically dopamine and corticotropin releasing factor in canonical reward pathways, play in escalated drug consumption to better understand neuropathology, and develop harm reducing therapeutics for substance use disorders.

PI_NAMEs: GORDON-FENNELL, LYDIA  (contact)

PROJECT_TERMS: addiction liability;Address;Animal Model;Animals;Behavior;Behavioral;Bilateral;Biosensor;Brain Diseases;Brain region;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;combat;combinatorial;comparison control;Consumption;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;Coupled;CRF receptor type 1;CRF receptor type 2;Cues;design;Dopamine;dopamine system;driving force;Drug abuse;Drug Controls;drug of abuse;Drug usage;Dynorphins;Epidemic;experimental study;Fiber;Frequencies;Future;Genes;Globus Pallidus;Goals;Harm Reduction;high risk;Human;Individual;insight;Intake;Knock-out;Maps;Measurement;Measures;Mediating;Midbrain structure;Modeling;Monitor;nerve supply;neural circuit;Neurobiology;neuromechanism;Neurons;neuropathology;neuroregulation;Neurosciences;novel therapeutics;Nucleus Accumbens;Opioid;Outcome;Overdose;overdose death;overdose risk;Pathway interactions;Pharmaceutical Preparations;Phase;Phenotype;Photometry;Physiological;Play;prevent;Productivity;Public Health;Receptor Activation;reduced substance use;Regimen;Relapse;Research;response;Rewards;Role;Self Administration;sensor;Side;Signal Transduction;Societies;Specific qualifier value;Substance of Abuse;substance use;Substance Use Disorder;System;Techniques;Technology;Testing;Therapeutic;therapeutic target;Training;Transfection;United States;Ventral Tegmental Area;Viral;Withdrawal;Work

PROJECT_TITLE: The role of corticotropin-releasing factor in modulating accumbal dopamine and producing escalation of drug intake


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE  A host’s physiology is contingent on the composition of their microbiome. While a major player in shaping the commensal population is the host’s genetics, due to insufficient models, the mechanisms by which this occurs is unclear. Herein, we describe our murine model in which host-commensal relationships driven by genetics, independent of environmental factors, can be discovered and the mechanism determined by a multifaceted approach spanning immunology, microbiology, genetics, and computational analyses.

PI_NAMEs: LIETUVNINKAS, HELEN BEILINSON (contact)

PROJECT_TERMS: Acute;adaptive immune response;alpha-Defensins;anti-microbial peptide;Autoimmunity;Automobile Driving;Bacteria;bacterial community;Basic Science;Behavior;career;Chicago;Chromosome Mapping;colonization resistance;commensal bacteria;commensal microbes;Complement;Computer Analysis;Correlative Study;Data;Dedications;Diet;Digestion;Dominant Genetic Conditions;dysbiosis;Environmental Risk Factor;experimental study;Food;gastrointestinal;Genes;Genetic;genetic analysis;Genetic study;Germ-Free;Gnotobiotic;Goals;Growth;gut bacteria;gut dysbiosis;gut microbiome;Health;host microbiome;Human;Immune system;Immunologist;Immunology;in vivo;Inbred BALB C Mice;Inbred Strains Mice;Individual;Infection;Innate Immune Response;Integration Host Factors;interdisciplinary approach;Intestines;Kinetics;Laboratories;Lactobacillus;Location;Maintenance;member;Mentors;Microbe;microbial composition;Microbiology;microbiome;microbiome composition;microorganism;Modeling;mouse model;mucosal site;Mucous body substance;Mus;Necrotizing Enterocolitis;Newborn Infant;nonhuman primate;Nutrient;nutrition;pathogen;pathogenic virus;Phenotype;Physiology;Play;Population;positional cloning;Postdoctoral Fellow;resident commensals;Resources;response;Role;Shapes;Small Intestines;Systems Development;Testing;Time;Training;Twin Studies;Universities;uptake;Vascularization

PROJECT_TITLE: The Role of Host Genetics in Shaping Intestinal Lactobacillus Population

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics

ORG_CITY: SHREVEPORT

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: PROJECT NARRATIVE The interplay between inflammation and fibroproliferative vascular remodeling critically regulates the vulnerability of atherosclerotic plaques. Our research identifies members of the Eph/ephrin family of guidance molecules as novel players in these processes, regulating ligand-dependent inflammation and ligand- independent smooth muscle fibroproliferative remodeling. Targeting this differential signaling response therapeutically may allow for simultaneous inhibition of inflammation and promotion of fibroproliferative remodeling.

PI_NAMEs: ORR, ANTHONY WAYNE (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Adhesions;Affect;Arterial Fatty Streak;Atherosclerosis;Automobile Driving;Binding;Binding Proteins;cardiovascular disorder risk;cell type;Cell-Matrix Junction;Cells;Data;Deposition;Endothelial Cells;Endothelium;EphA2 Receptor;Ephrins;Extracellular Matrix;Family;Fibronectins;Focal Adhesions;Gene Expression;Genetic Polymorphism;GTF2I gene;Human;Hypertension;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Injury;Integrins;knock-down;Knockout Mice;Leukocytes;Ligands;Ligation;Macrophage;Mediating;member;migration;monocyte;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;pharmacologic;Phenotype;Phosphorylation;prevent;Process;Proliferating;recruit;Regulation;Research;Role;Rupture;Signal Pathway;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Stenosis;TFII Transcription Factors;transcription factor;transcriptome sequencing;Transgenic Mice;treatment response;Tumor Suppressor Proteins;Vascular remodeling

PROJECT_TITLE: EphA2 regulation of atherosclerotic smooth muscle phenotype

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Mental Health;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Despite social determinants’ known impact on the mental health of vulnerable and trauma-affected populations, including forcibly displaced people, there is little evidence from low-resource settings on the mechanisms by which these determinants affect mental health. The proposed project will utilize data from one of the first representative longitudinal studies with refugees in any context to: 1) identify the latent factor structure of displaced Syrians’ social determinants of mental health, 2) examine the main causal effects of social determinants and trauma exposure on mental distress, and 3) evaluate whether social determinants moderate the relationship between trauma exposure and mental distress. Findings from this study will inform measurement and targeting strategies for preventive interventions, also offering a methodological approach that can improve understanding of social determinants’ structure and significance in diverse populations of concern.

PI_NAMEs: YAN, LAUREN NICOLE (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acute Disease;Address;Adult;Affect;Anxiety;Area;career;climate change;Complex;Conflict (Psychology);Critical Illness;Data;Data Set;design;Development;Dimensions;Disease;displaced person;Distress;Economics;Education;Employment;Evaluation;experience;Face;Factor Analysis;Fellowship;Goals;Household;Housing;improved;Income;innovation;Intervention;Jordan;Knowledge;Life;Literature;Longitudinal Studies;low and middle-income countries;Measurement;Mental Depression;Mental disorders;Mental Health;Mentorship;Methodology;Methods;Middle East;Modeling;National Institute of Mental Health;Natural Disasters;Personal Satisfaction;Policies;Politics;Population;Population Heterogeneity;Prevalence;prevent;Prevention strategy;Preventive;preventive intervention;Productivity;Psyche structure;Refugees;Research;Research Personnel;Resource-limited setting;Sampling;secondary analysis;Services;skills;social;social determinants;social interventions;Strategic Planning;Structure;Surveys;Training;Trauma;trauma exposure;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: Social determinants, trauma, and mental distress among forcibly displaced populations in low- and middle-income countries


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: NORMAN

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Project Narrative Established treatments for Fragile X Syndrome (FXS) are often insufficient at reducing intellectual disability, executive dysfunction, or behavioral features of FXS – largely because underlying mechanisms of FXS remain poorly understood. The proposed research will investigate functional connectivity disruptions in frontoparietal and temporal networks using electroencephalography (EEG) to parse cognitive function/intellectual disability as separate from other features of FXS (e.g., anxiety, hypersensitivities) during a cognitive task with a secondary goal of establishing the feasibility of microstates as a simpler proxy for network disruptions. This study is essential for defining mechanistic underpinnings behind core symptoms in FXS for better biomarker development which are then implementable in evaluations of novel therapeutic interventions (i.e., physiological bridges between molecular targets and externally measurable symptom improvements).

PI_NAMEs: NORRIS, JORDAN  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Accounting;Address;Age;Anxiety;Auditory;autism spectrum disorder;autistic;Behavior;Behavioral;behavioral response;Biological Markers;biomarker development;Brain;Characteristics;Clinical;clinical practice;Code;Cognition;Cognitive;cognitive ability;cognitive control;Cognitive deficits;cognitive function;cognitive task;Data;density;Development;Developmental Delay Disorders;effectiveness evaluation;Electroencephalography;Evaluation;Event;Event-Related Potentials;Executive Dysfunction;Exhibits;experimental study;flexibility;FMR1 gene;Fragile X Syndrome;Functional disorder;Future;Goals;Head;Heterogeneity;Hyperactivity;Hypersensitivity;Impaired cognition;Incidence;indexing;Individual;Inherited;insight;Intellectual functioning disability;Intervention;Knowledge;Learning Difficulty;Link;Machine Learning;machine learning algorithm;male;Measurable;Measures;Mendelian disorder;Methods;Molecular Target;Mutation;neural;neural network;Neurodevelopmental Disorder;neuromechanism;neurophysiology;non-verbal;novel;novel strategies;novel therapeutic intervention;Nucleotides;Participant;Pattern;Performance;Phase;Physiological;Population;predicting response;Process;Proxy;Research;response;Rest;Reversal Learning;Sampling;Science;Sensory;Severities;sex;social anxiety;Source;Stimulus;Subgroup;symptomatic improvement;Symptoms;Techniques;Therapeutic;Translations;treatment effect;United States National Institutes of Health;Use Effectiveness;Variant;Weight;Work;X Chromosome

PROJECT_TITLE: Network mechanisms underlying core behavioral features in Fragile X Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE This study will help clarify the contribution of socioeconomic status over the life course to epigenetic age acceleration across adulthood. The proposed research will illuminate modifiable socioeconomic factors in early life and adulthood which may inform the design of interventions to reduce biological aging and age- related degenerative disease. This study will address the socioeconomic drivers of biological aging in a lower-middle-income country where rising life expectancies are placing increased demands on public health and clinical infrastructures.

PI_NAMEs: WATSON, ELIJAH JILES (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: accelerated epigenetic aging;Address;Adult;Affect;Age;age acceleration;age related;age related decline;age-related disease;Aging;aging biomarker;aging related;Biological Aging;Biological Markers;Birth;Blood specimen;cardiovascular disorder risk;Cardiovascular system;Child;Chronology;clinical infrastructure;Clinical Markers;Cohort Studies;Data;Degenerative Disorder;Dimensions;DNA Methylation;Economic Conditions;Education;Epidemiologic Methods;Epidemiology;epigenetic aging;epigenetic clock;Evaluation;Filipino;follow-up;functional decline;Future;Generations;Health;Health behavior;Health Surveys;high school;Household;Immune;immune function;improved;indexing;Individual;Inequity;Inflammation;Inflammatory;innovation;intergenerational;late life;Life;Life Cycle Stages;Life Expectancy;Life Style;Link;low and middle-income countries;low socioeconomic status;machine learning algorithm;Maximum Likelihood Estimate;Measures;Mediating;Mediation;Memory;Metabolic;Methods;metropolitan;mortality;Mothers;Nutrition Surveys;offspring;Outcome;Outcome Measure;Parents;Participant;pathological aging;Performance;phenotypic biomarker;Philippines;Preventive measure;Probability;prospective;Proxy;Public Health;Research;Selection Bias;semiparametric;skills;social;social epidemiology;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Statistical Methods;Testing;therapy design;Time;Training;Training Activity;Variant;Visit;Weight;Woman;young adult

PROJECT_TITLE: Socioeconomic status across the life course and epigenetic age acceleration in adulthood: Evidence from two generations of a Filipino birth cohort study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE: Development of effective therapies for obesity-associated hypertension have been hindered by our limited understanding of the mechanisms by which excess adiposity drives cardiovascular disease (CVD). This fellowship proposal tests how the adipokine chemerin that is produced in the vasculature supports blood pressure and drives adiposity-associated hypertension and vascular stiffening. Through completion of this project, the applicant will develop key technical skills to highlight chemerin as a therapeutic target in obesity-associated hypertension and CVD as well as professional skills that will prepare her for a successful career as a clinical industrial scientist.

PI_NAMEs: WABEL, EMMA  (contact)

PROJECT_TERMS: Acute;adipokines;Adipose tissue;Affect;Animals;antagonist;Anti-Hypertensive Agents;Antisense Oligonucleotides;Aorta;Automobile Driving;Biological;Biological Markers;Blood Pressure;blood pressure reduction;blood pressure regulation;Blood Vessels;Cardiovascular Diseases;career;Clinical;CMKLR1 gene;comorbidity;Contracts;Data;Development;Diet;Disease;effective therapy;Elements;Essential Hypertension;Extrahepatic;falls;Fatty acid glycerol esters;Fellowship;Female;Frequencies;Genes;Genetic;Health;Hepatic;High Fat Diet;Human;Hypertension;hypertensive;Immunohistochemistry;in vivo;Industrialization;Inflammation;Inflammatory;Isometric Exercise;Knock-out;Link;Liver;male;Measures;Medial;Metabolic Diseases;novel;Obesity;obesity treatment;Pathologic;Pathology;pharmacologic;Play;Prevalence;prevent;Production;Proteins;Rattus;receptor;Relaxation;Retinoic Acid Receptor;Role;Scientist;skills;Smooth Muscle Myocytes;Source;success;targeted treatment;Technical Expertise;Testing;therapeutic target;therapy development;tool;Training;transcriptomics;Translations;Ultrasonography;Vascular Smooth Muscle;Vasoconstrictor Agents;Vasodilation;Visceral fat;Visualization;Western Blotting;Work

PROJECT_TITLE: Role of Vascular Chemerin as a Regulator of Blood Pressure and Contributor to Cardiovascular Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Digestive Diseases;Inflammatory Bowel Disease;Mental Health;Mental Illness;Neurosciences;Pediatric;Rehabilitation

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Consistent with a brain-gut axis conceptualization of disease, adolescents diagnosed with inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, are at increased risk for dysfunction of the autonomic nervous system indicative of a chronic stress response as well as psychological distress characterized by anxiety and depressive symptoms. This randomized waitlist-controlled trial will test efficacy of a virtually delivered, group-based coping skills treatment program incorporating heart rate variability biofeedback to target autonomic dysfunction. The long-term goal of this research is to provide a scalable, innovative behavioral treatment option for the growing number of pediatric patients affected by IBD to treat psychological distress and disease activity.

PI_NAMEs: REED, BONNEY  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: 18 year old;Abdominal Pain;activity marker;Address;Adolescent;Adult;Affect;Age;Anxiety;Anxiety Disorders;anxiety symptoms;arm;Autonomic Dysfunction;Autonomic nervous system;Behavior Therapy;Biofeedback;Biofeedback Training;biological adaptation to stress;Biological Markers;C-reactive protein;Cardiac;Central Nervous System;Child health care;Childhood;children's depression inventory;Chronic;Chronic Disease;Chronic stress;Clinic;Clinical;Clinical Trials Design;clinically relevant;Cognitive Therapy;Communication;comparison control;Coping Skills;Crohn's disease;Depressive disorder;depressive symptoms;Diagnosis;Disease;Disease Marker;Educational process of instructing;efficacy testing;Emotional;emotional distress;evidence base;Evidence based intervention;experience;follow-up;Frequencies;Functional disorder;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal tract structure;Goals;gut-brain axis;heart rate variability;Immune;improved;indexing;Individual;Inflammation;Inflammatory Bowel Diseases;inflammatory marker;innovation;intervention effect;Irritable Bowel Syndrome;Leukocyte L1 Antigen Complex;Measures;Mediating;Medical;Mental Depression;Modeling;multidisciplinary;Nervous System Physiology;Outcome;Patient Self-Report;Patients;pediatric patients;perceived stress;Physicians;Prevalence;psychologic;psychological distress;psychological outcomes;psychological symptom;psychosocial;Quality of life;Race;Randomized;Randomized, Controlled Trials;recruit;Regulation;Reporting;Research;Rest;Risk;Role;Sampling;satisfaction;Serum;Services;sociodemographics;Stress;Subgroup;Symptoms;Testing;Time;treatment effect;Treatment Efficacy;treatment program;Ulcerative Colitis;virtual;virtual delivery;virtual intervention;Waiting Lists;Work;Youth

PROJECT_TITLE: A Heart Rate Variability Biofeedback Enhanced Behavioral Intervention to Improve Psychological and Disease Functioning in Youth with Inflammatory Bowel Disease (IBD)

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Immunotherapy;Pancreatic Cancer;Radiation Oncology;Rare Diseases

PHR: Narrative Head and neck cancer (HNSCC) and pancreatic ductal adenocarcinoma (PDAC) exhibit dichotomous responses to combination radiation immunotherapy in the context of OX40 agonism, highlighted by decreased CD8 T cell effector function and enhanced regulatory T cell (Treg) suppression, resulting in diminished survival in PDAC models. The PDAC tumor microenvironment (TME) is rich in IL-33 and Tregs which express the cognate receptor ST2. We aim to determine the differential responses to OX40 agonism between HNSCC and PDAC, and whether the IL-33/ST2 axis on Tregs promotes a suppressive TME.

PI_NAMEs: GADWA, JACOB  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Ablation;Acceleration;Address;Affinity;Aftercare;anti-tumor immune response;Antitumor Response;Biological Assay;Cancer Model;cancer therapy;cancer type;career;CD8-Positive T-Lymphocytes;Cell Line;Cell Physiology;Cells;Characteristics;Clinical;Clinical Trials;Combination immunotherapy;combinatorial;cytokine;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Disparity;effector T cell;Exhibits;experimental study;Flow Cytometry;Future;Gene Expression;Genetic;Genetically Engineered Mouse;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;IL2 gene;Immune;immune checkpoint;immune checkpoint blockade;Immune response;Immunosuppression;Immunotherapy;Implant;in vivo;Infiltration;Inflammatory;inhibitor;Interleukin-2;Intrinsic factor;Mediating;Mediator;Modeling;Mus;Natural Killer Cells;Neoplasm Metastasis;OX40;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;Pancreatic Ductal Carcinoma;Patients;pharmacologic;Phenotype;Population;pre-clinical;Pre-Clinical Model;Principal Investigator;programmed cell death protein 1;Publishing;Radiation;Radiation therapy;Radioimmunotherapy;receptor;Regimen;Regulatory T-Lymphocyte;Resistance;response;Sampling;Shapes;Signal Transduction;single-cell RNA sequencing;Site;success;synergism;T-Cell Activation;Testing;Therapeutic;therapy outcome;therapy resistant;transcriptome sequencing;trial design;tumor;Tumor Burden;tumor eradication;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-Derived;Vertebral column

PROJECT_TITLE: Divergent response to radio-immunotherapy in HNSCC and PDAC is mediated by regulatory T cells

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PHR: PROJECT NARRATIVE Renal afferent sensory nerves contribute to the development of salt-induced hypertension via input to central autonomic brain regions that modulate sympathetic outflow to other organs. This proposal will expand the understanding of how renal afferents are involved in salt-induced hypertension and establish an anatomical foundation for future investigations into the physiological roles of renal afferents in the autonomic control of blood pressure. With this insight, the field will have a better understanding of afferent renal input from the kidney leading to the development of interventions that can accurately target renal afferents, both peripherally and centrally, increasing the therapeutic potential of afferent renal denervation as a treatment for hypertension.

PI_NAMEs: DAILEY-KREMPEL, BRIANNA  (contact)

PROJECT_TERMS: Ablation;Acetates;Address;afferent nerve;anakinra;Anatomy;Animals;antagonist;Attenuated;Autonomic Pathways;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure regulation;Brain;brain pathway;Brain region;Brain Stem;Cardiometabolic Disease;Catheters;Cells;Central Nervous System;Chemicals;Chronic;Clinical Trials;Denervation;Deoxycorticosterone;Dependovirus;Development;dorsal horn;Exposure to;Fiber;FOS gene;Foundations;Future;Genetic Recombination;Goals;Hypertension;hypertension treatment;Hypothalamic structure;Immediate-Early Genes;Immunohistochemistry;Induced Neurons;inducible Cre;Inflammation;insight;Interleukin-1 Receptors;Investigation;Kidney;kidney cortex;Knowledge;Label;Laboratories;Measures;mechanical stimulus;Modeling;mouse model;Mus;Nerve;nerve supply;neural;neural circuit;neurogenic hypertension;Neurons;Nodose Ganglion;novel;Nucleus solitarius;Organ;Outcome;Output;Paper;paraventricular nucleus;Pathogenesis;Patients;Peripheral;Physiological;Population;Process;Proteins;Renal function;Renal pelvis;Reporter;Resistant Hypertension;Risk;Rodent Model;Role;salt intake;salt sensitive hypertension;Secondary to;Sensory;Signal Transduction;Site;Sodium;Sodium Chloride;Specificity;Spinal Cord;Spinal Ganglia;Tamoxifen;theories;Therapeutic;therapy development;Tissues;Travel;Viral Vector;Visualization;Water;Work

PROJECT_TITLE: Renal Afferent Nerve Circuitry and Pathogenesis on Blood Pressure Regulation