NIH_SPENDING_CATS: Biotechnology;Clinical Research;Lung;Precision Medicine;Prevention;Pulmonary Fibrosis

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative In this proposal, we will identify proteins that predict progression in patients with non-idiopathic pulmonary fibrosis forms of interstitial lung disease. We will then use these proteins to develop a blood-based tool to accurately predict progression in those with early/mid-stage disease, as these patients are most likely to benefit from early therapeutic intervention.

PI_NAMEs: OLDHAM, JUSTIN M (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Adoption;antifibrotic treatment;biobank;Biological;Biological Markers;biomarker development;Blood;blood-based biomarker;Canada;Characteristics;Clinical;clinical implementation;clinically actionable;clinically relevant;cohort;Collaborations;comparative;Custom;Data;Development;Diagnosis;Disease;Disease Outcome;Early identification;Etiology;fibrotic interstitial lung disease;Foundations;Genomics;Goals;idiopathic pulmonary fibrosis;improved;Incidence;Interstitial Lung Diseases;Intervention;Investigation;Knowledge;Length;Leukocytes;Machine Learning;machine learning algorithm;Malignant Neoplasms;Mediator;Nature;new therapeutic target;novel;novel marker;Outcome;Pathway Analysis;Patients;Performance;performance tests;peripheral blood;Plasma;Population;Positioning Attribute;prevent;Productivity;Prognostic Marker;prospective;protein biomarkers;Proteins;proteomic signature;Proteomics;Pulmonary Fibrosis;pulmonary function decline;Qualifying;Radiology Specialty;radiomics;recruit;Sampling;Sensitivity and Specificity;Specificity;telomere;Testing;Therapeutic Intervention;therapeutic target;tool;Transplantation;treatment disparity;Validation;Work;X-Ray Computed Tomography

PROJECT_TITLE: Prognostic Biomarker Development in Progressive Fibrosing Interstitial Lung Disease

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Prevention;Substance Misuse

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_STATE: MI

PHR: PROJECT NARRATIVE We propose to build on recent advances in the novel translation of a well-established animal model of addiction by delineating the neurobehavioral signatures of human sign- and goal-tracking. The long-term goal of this line of work is to identify early those who are at the highest risk for addiction. Ultimately, this information could be used by researchers and clinicians to limit the transition to addiction, reduce relapse rates, and improve human health.

PI_NAMEs: COPE, LORA M. (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 20 year old;addiction;addiction liability;Address;age group;aged;Animal Model;Animals;Association Learning;Attention;attentional control;Attenuated;Beer;Behavior;Behavioral;behavioral phenotyping;Brain;Cannabis;causal model;Clinical;coping;cue reactivity;Cues;Diagnosis;Early identification;emerging adult;emerging adulthood;Extinction;Female;Food;Functional Magnetic Resonance Imaging;Glass;Goals;Health;high risk;Human;Hyperactivity;improved;Impulsivity;incentive salience;Incentives;Individual;Individual Differences;Inferior frontal gyrus;innovation;Investigation;Knowledge;Learning;Life;Literature;Location;Measures;Modeling;Motivation;neural;neurobehavioral;neuroimaging;novel;Outcome;Participant;Patient Self-Report;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical study;preference;Process;Property;Protocols documentation;Psychometrics;recruit;Relapse;Research;Research Personnel;reward processing;Rewards;Risk;Risk Factors;Rodent;Self Administration;Signal Transduction;Smell Perception;Stimulus;substance use;Substance Use Disorder;sustained attention;theories;Time;tool;trait;Translating;translation to humans;translational neuroscience;Translations;Validation;Work

PROJECT_TITLE: Neurobehavioral signatures of sign- and goal-tracking in emerging adults: Translation of a preclinical model

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: KENNESAW

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: KENNESAW STATE UNIVERSITY

ORG_STATE: GA

PHR: This research study proposes to quantify the relationship between daily step counts and body composition/cardiometabolic disease risk factors in young, middle-aged, and older adults who are overweight/obese, and to then employ that relationship in prescribing step counts to achieve predictable changes in body weight and composition, and cardiometabolic risk status. This research project is highly relevant to public health: the numbers of overweight and obese adults continue to rise in all age groups, and the epidemic prevalence of excess body fatness and its comorbidities imposes an increasingly serious burden on health care costs and quality of life. Results from this research study may provide a new and powerful tool for prescribing physical activity for weight/cardiometabolic disease management in people adults of all ages, and have significant clinical and public health applications.

PI_NAMEs: BURESH, ROBERT  (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Adult;adult obesity;Age;age group;age related changes;age-related disease;American;Behavioral;Behavioral Research;blood glucose regulation;Body Composition;Body fat;Body Weight;Body Weight decreased;Calories;Cardiometabolic Disease;cardiometabolic risk;Clinical;clinical application;comorbidity;cost;Data;Desire for food;Development;dietary restriction;disability;Disease;Disease Management;Eating;effective intervention;Elements;energy balance;Energy Intake;Energy Metabolism;Epidemic;Exercise;Fatty acid glycerol esters;Goals;Health;Health Care Costs;improved;Investigation;Laboratories;Life Style;Lipids;mathematical model;men;middle age;Mission;Modeling;Modernization;National Institute on Aging;Nature;Obesity;older adult;Outcome;Overweight;pedometer;Personal Satisfaction;Persons;Physical activity;Pilot Projects;Plasma;precision medicine;Prevalence;prevent;Public Health;Public Health Applications Research;Quality of life;Regulation;Research;Research Personnel;Research Project Grants;research study;Risk;Risk Factors;Risk Management;social;statistics;tool;United States;Weight;weight loss intervention;weight loss program;Weight maintenance regimen;Woman;Work;young adult

PROJECT_TITLE: Prescription of Step Counts for Targeted Changes in Body Composition and Cardiometabolic Risk in Overweight/Obese Adults

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: CHARLOTTE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE Vesicular stomatitis virus (VSV) is a promising oncolytic virus (OV) against pancreatic ductal adenocarcinoma (PDAC), which makes up to 95% of pancreatic cancers, and will soon be the second leading cause of cancer- related deaths in the United States. The proposed studies are based on our recently published work where we generated novel PDAC-targeted oncolytic VSV variants that can better infect and kill PDAC cells without harming non-malignant cells. The proposed study will investigate the mechanism of the improved oncoselectivity and will examine these viruses alone or in combination with FDA-approved drug Ruxolitinib and/or anti-PD-1 antibody using clinically-relevant immunocompetent orthotopic mouse models of PDAC.

PI_NAMEs: GRDZELISHVILI, VALERY ZURABOVICH (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Academic Research Enhancement Awards;Adenoviruses;anti-cancer;anti-PD-1;anti-PD1 antibodies;anti-tumor immune response;Armenia;Award;Biological Markers;Biology;cancer cell;Cancer Etiology;Cell Line;Cells;Cessation of life;Characteristics;Chemoresistance;chemotherapeutic agent;chemotherapy;China;Chronic;Clinical;clinically relevant;combinatorial;Combined Modality Therapy;Complex;Data;Development;Disease;Early Diagnosis;efficacy evaluation;Enteral;Environment;European Union;Evolution;Excision;experimental study;FDA approved;Friends;Glioblastoma;Goals;Grant;Head and Neck Squamous Cell Carcinoma;Hepatitis Delta Virus;Herpesvirus 1;Human;immune checkpoint blockade;Immunocompetent;Immunotherapy;improved;In Vitro;in vivo;Incidence;Inflammation;inhibitor;Integration Host Factors;Interferons;JAK1 gene;JAK2 gene;Japan;Laboratories;Latvia;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Melanoma;Molecular;mouse model;Neoplasm Metastasis;Non-Malignant;Normal tissue morphology;novel;novel therapeutic intervention;novel virus;oncolysis;Oncolytic;oncolytic Vesicular Stomatitis Virus;oncolytic virotherapy;Oncolytic viruses;Operative Surgical Procedures;Orphan;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Patients;permissiveness;Pharmaceutical Preparations;Phase I Clinical Trials;Phenotype;pre-clinical;Prognosis;programs;Publishing;Relapse;Reporting;Research;Resectable;Residual state;Resistance;resistance mechanism;Resources;response;Safety;Signal Transduction;success;System;Testing;TP53 gene;Treatment-related toxicity;tumor;Tumor Immunity;undergraduate education;undergraduate student;United States;Variant;Vesicular stomatitis Indiana virus;Viral;Virus;Virus Replication;Work

PROJECT_TITLE: Understanding and improving novel oncolytic viruses for pancreatic cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-J (80)]


ADMINISTERING_IC: DK

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Genetics;Nutrition;Obesity

ORG_CITY: STILLWATER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: PROJECT NARRATIVE As obesity has become pandemic globally, and it is highly associated with diabetes, hypertension, cardiovascular diseases and several types of cancer, there is an urgent need to develop efficient therapeutic approaches to treat obesity. Since targeting macrophage polarization is a promising strategy, we here propose to verify the deletion of CTRP6 gene could polarize macrophages to anti- inflammatory phenotype as well as develop a cell-based therapeutic strategy using genetically modified CTRP6 knockout macrophages. These studies will significantly contribute to the fundamental knowledge of molecular regulation of macrophage polarization involved in the pathogenesis of adipose tissue inflammation and insulin resistance and bring light upon effective immunotherapy for obesity.

PI_NAMEs: LEI, XIA  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Ablation;Adipocytes;Adipose tissue;Anti-Inflammatory Agents;Attenuated;Biological Assay;Biomedical Research;cancer type;Cardiovascular Diseases;Cell Culture Techniques;Cell Line;Cell model;Cell Therapy;Cells;Coculture Techniques;Complement 1q;CRISPR/Cas technology;Data;Development;Diabetes Mellitus;diabetic;Diet;Dose;Education;experience;Exposure to;Female;Gene Modified;Genes;Genetic Markers;Glucose;Glucose Intolerance;Glucose Transporter;glucose uptake;GLUT 4 protein;Goals;High Fat Diet;human model;Hypertension;Immune;Immunotherapy;improved;Infiltration;Inflammation;Inflammatory;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;intravenous injection;Investigation;Knock-out;Knockout Mice;Knowledge;Light;Macrophage;Mediating;member;Metabolic;Metabolic Diseases;Modernization;Molecular;Molecular Cloning;mouse model;Nitric Oxide;Nuclear;Nuclear Protein;Obesity;obesity development;obesity prevention;obesity treatment;Oklahoma;pandemic disease;Pathogenesis;Phagocytosis;Phenotype;Play;Prevention strategy;Production;programs;Protein Family;Protein Secretion;Proteins;Publications;Recombinant Proteins;Recombinants;Regulation;Research;Research Infrastructure;Resistance;Role;Serum;Signal Pathway;skill acquisition;Source;Stimulus;Students;System;Techniques;Therapeutic;TNF gene;transcriptomic profiling;treatment strategy;undergraduate student;Underrepresented Minority;Universities;Visceral fat

PROJECT_TITLE: Immunometabolic Regulation of Adipose Tissue by CTRP6


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Complementary and Integrative Health;Dietary Supplements;Drug Abuse (NIDA only);Microbiome;Neurosciences;Nutrition;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Substance Misuse

ORG_CITY: DURHAM

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

ORG_STATE: NH

PHR: Chronic opioid use produces analgesic tolerance and opioid use disorder (OUD) in only a subset of both humans and mice. Identifying and validating the biomarkers that predict liability for OUD could improve therapeutic utility and reduce risk.

PI_NAMEs: WHISTLER, CHERYL ALLYNE (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Acute;addiction;Adult;Analgesics;Antibiotics;antinociception;Archives;Behavioral;Binding;Biological;Biological Availability;Biological Markers;biomarker validation;Brain;Central Nervous System Diseases;Chronic;chronic pain management;chronic painful condition;Collaborations;Communities;Complex;Consumption;Data;Development;Disease;Dose;dysbiosis;Ensure;Environment;Epilepsy;Etiology;Funding Mechanisms;Future;Generations;gut dysbiosis;gut homeostasis;gut microbiome;gut microbiota;gut-brain axis;Human;Hyperalgesia;immunoregulation;improved;Inflammation;Inflammatory;Institution;Intervention;Length of Stay;Malignant Neoplasms;Mammals;microbial;microbial community;microbiome;microbiome analysis;microbiome composition;Modeling;Molecular;Morphine;morphine administration;morphine tolerance;mouse model;Mus;Natural Immunity;Neuroimmune;Neurotransmitters;Nociception;Non-Insulin-Dependent Diabetes Mellitus;Opioid;opioid abuse;Opioid Analgesics;opioid mortality;opioid overdose;Opioid Receptor;opioid use;opioid use disorder;Oral;overdose death;Pain;pain patient;pain relief;pathogen;Pathology;Patients;Peptides;Persons;Pharmaceutical Preparations;Pharmacology;Phenotype;Physical Dependence;Play;Postoperative Pain;predictive marker;prescription opioid;Probiotics;Reporting;Research;response;Rewards;Risk;Risk Reduction;Role;Safety;Sampling;Science;side effect;Sister;skills;stem;student training;Supplementation;Testing;Therapeutic;therapeutic development;trend;undergraduate student;Ventilatory Depression

PROJECT_TITLE: Probiotic neuroimmune modulation of morphine tolerance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-R (86)]


ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Physical Activity;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The psychological symptom cluster is a common and significant problem that impacts women receiving breast cancer treatment and is associated with several negative outcomes, including reduced functional status and quality of life. Unfortunately, the social, environmental, and molecular mechanism(s) that drive the development and persistence of this cluster are unknown which limits the development of effective prevention strategies and targeted interventions. This project will examine the role of multiple social determinants of health and epigenomic factors in the development and severity of a psychological symptom cluster in women receiving breast cancer treatment which will provide new knowledge to guide clinical assessment and the development of targeted interventions to mitigate the severity of this cluster.

PI_NAMEs: HARRIS, CAROLYN STIGGE (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adjuvant Therapy;Aerobic Exercise;Age;Anxiety;Aromatase Inhibitors;associated symptom;Bioinformatics;Biological;Blood specimen;Breast Cancer therapy;Breast Cancer Treatment;Cancer Patient;Cancer Survivor;cancer therapy;cancer type;career development;Clinical assessments;Clinical Trials;common symptom;Communities;community-level factor;Competence;Data;deprivation;Development;Distress;Division of Cancer Prevention;DNA Methylation;Education;Employment;Environment;epigenetic regulation;epigenomics;Evaluation;Exercise;exercise intervention;experience;Fatigue;functional status;Genes;Goals;health determinants;Health Disparities Research;Immunotherapy;improved;Individual;inhibitor therapy;innovation;insight;Intervention;Investigation;Knowledge;Knowledge acquisition;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Mental Depression;Mentors;Methylation;methylome;Molecular;mortality;National Institute on Minority Health and Health Disparities;Neighborhoods;novel;Oncology;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Policy Developments;Pollution;pre-doctoral;Prevention strategy;psychological symptom;Quality of life;Race;Randomized;randomized, clinical trials;reduce symptoms;Research;Research Priority;Risk;Risk Factors;Role;Severities;skill acquisition;skills;Sleep disturbances;social;social health determinants;social influence;Socioeconomic Status;symptom cluster;symptom science;Symptoms;Testing;Time;Training;treatment as usual;United States;Universities;Woman

PROJECT_TITLE: Influence of Social Determinants of Health and Epigenomics on Psychological Symptom Cluster Severity

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (O1)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: CHARLESTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The NIH Stroke Net is a research network infrastructure to efficiently conduct clinical trials to identify intervention for: (1) acute treatment of stroke; (2) prevention of stroke recurrence; and (3) recovery and rehabilitation after stroke. The National Data Management Center (NDMC) of the NIH Stroke Net offers economies of scale through its centralized clinical management system to conduct multiple stroke clinical trials simultaneously and efficiently. This is expected to have an impact on the public health by potentially reducing stroke occurrences and the burden of stroke to the individuals as well as to the society.

PI_NAMEs: DILLON, CATHERINE R.;ELM, JORDAN J. (contact);ZHAO, WENLE

PROGRAM_OFFICER_NAME: MCCARTHY, SEAN PATRICK

PROJECT_TERMS: Acute;adjudication;Affect;Age;Ancillary Study;Area;arm;Biological Markers;biomarker validation;Case Report Form;central database;Clinical;Clinical Management;clinical practice;clinical research site;Clinical Trials;Collaborations;Common Data Element;Communities;Conduct Clinical Trials;Consent;Data;Data Collection;Data Coordinating Center;data dissemination;data management;Data Management Resources;data quality;Data Set;data sharing;Databases;design;Development;Devices;digital communication;Disabling;Disease;Documentation;Elderly;electronic data;Emergency Situation;Enrollment;Ensure;Equipment and supply inventories;experience;Feasibility Studies;Funding;Future;Grant;Health Resources;improved;Individual;industry partner;Infant;Information Management;Infrastructure;innovation;Intervention;Leadership;Libraries;Management Information Systems;Medical;Methods;Mission;Monitor;multi-site trial;multidisciplinary;National Institute of Neurological Disorders and Stroke;Network Infrastructure;neuroimaging;novel therapeutics;Online Systems;operation;Participant;Patient Representative;Patients;Pharmaceutical Preparations;Phase;Population;pre-clinical;Prevention;Principal Investigator;Process;protocol development;Public Health;Publications;Quality Control;Recovery;recruit;Recurrence;Regulation;Reporting;Research;Research Design;Research Infrastructure;Research Personnel;Research Priority;Role;Safety;Scientist;Site;Societies;South Carolina;Standardization;Statistical Methods;Stroke;stroke clinical trials;stroke incidence;Stroke prevention;stroke recovery;stroke rehabilitation;stroke therapy;stroke trials;StrokeNet clinical trials;System;telerehabilitation;Testing;tool;Training;trial design;United States National Institutes of Health;Universities;validation studies

PROJECT_TITLE: Stroke Trials Network National Data Management Center (NDMC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (16)]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Skin Cancer

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Melanoma recurrence from the early-stage primary tumor accounts for most melanoma mortality but is often undetected until the disease has spread to lymph nodes or distant organs. While the recent approval of immunotherapy for managing patients with early-stage melanomas provides a potential opportunity to improve patient outcomes, it requires an accurate prognostic prediction tool to identify patients for whom the risk of melanoma recurrence and metastasis would justify the potentially significant adverse events of systemic immunotherapy. We propose to address this critical public health need by leveraging recent advances in multiplexed tissue imaging, spatial transcriptomics, and artificial intelligence to characterize the early-stage melanoma microenvironment, understand mechanisms underlying its recurrence, and build an explainable machine-learning-based forecasting platform that can be deployed in clinics to aid precision medicine.

PI_NAMEs: WAN, GUIHONG  (contact)

PROJECT_TERMS: Address;Adverse event;Antibodies;Artificial Intelligence;Automobile Driving;biobank;Biological;Biological Assay;Biological Markers;biomedical informatics;Biopsy Specimen;Cancer Biology;cancer imaging;Cells;Cessation of life;Characteristics;Clinic;Clinical;cohort;Computational Biology;Computer Analysis;computer framework;computer science;computerized tools;Computing Methodologies;Dana-Farber Cancer Institute;Data;design;Development;Diagnosis;Diagnostic;Disease;Distant;Doctor of Philosophy;Electronic Health Record;Ensure;explainable artificial intelligence;explainable machine learning;General Hospitals;Generations;Genomics;Goals;Hematoxylin and Eosin Staining Method;high risk;Histopathology;Hungary;Image;imaging modality;Immune;Immune response;Immunofluorescence Immunologic;Immunotherapy;improved;Institution;Knowledge;Laboratories;Leadership;lymph nodes;Machine Learning;machine learning algorithm;machine learning model;machine learning prediction;Malignant Neoplasms;Massachusetts;Measurable;medical schools;Melanoma;Melanoma Tumor;Mentors;Merkel cell carcinoma;Metabolism;Methods;model development;Modeling;Molecular;molecular marker;mortality;Multimodal Imaging;multimodality;multiplexed imaging;Neoplasm Metastasis;neoplastic cell;Neural Cell Adhesion Molecule L1;NGFR gene;novel marker;Organ;Outcome;Patient-Focused Outcomes;Patients;Performance;Periodicity;personalized medicine;Phase;Play;Positioning Attribute;post-doctoral training;precision medicine;predictive modeling;predictive tools;Primary Neoplasm;prognostic;Prognostic Factor;prognostic tool;Proliferating;Prospective cohort;Public Health;Recurrence;Recurrent disease;Registries;Research;Resolution;Risk;Role;Sampling;Signal Transduction;skills;Skin Malignancy;Slide;spatial integration;spatial relationship;Stains;System;Testing;Time;Tissue imaging;Tissues;Toxic effect;Training;transcriptomics;tumor;tumor immunology;tumor microenvironment;Tumor-infiltrating immune cells;United States;Universities;Validation

PROJECT_TITLE: Explainable Artificial Intelligence for Melanoma Recurrence Prediction via Integrative Modeling of Multiplexed Imaging with Transcriptomics and Histopathology


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences;Pediatric

PHR: Project Narrative Following rapid growth early in development, dendritic arbors achieve apparent stability in size across adolescence but continue to undergo refinements that ultimately lead to dendrite- mediated signal selectivity and mature cortical circuits. This developmental epoch is a period of vulnerability for the onset of multiple neuropsychiatric diseases, yet the underlying mechanisms governing this crucial refinement remain incompletely understood. This project seeks to identify the role of OMGp in adolescent dendritic development, specifically integrating studies spanning anatomical and functional characterization, to better link dendrites to circuits to physiology.

PI_NAMEs: GRUBISHA, MELANIE JEAN (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Acoustic Stimulation;Adolescence;Adolescent;Adult;Affect;Anatomy;Architecture;Auditory;Auditory area;awake;Biological Markers;Birth;cell type;D Cells;Data;Dendrites;Development;Disease;Electrophysiology (science);Equilibrium;Exhibits;experimental study;Functional disorder;Functional impairment;Future;gain of function;Growth;Impairment;In Vitro;in vivo;Inhibitory Synapse;insight;Interneurons;knock-down;Knock-out;Knockout Mice;Knowledge;Link;Mediating;Mediator;Missense Mutation;Modeling;Mus;Neocortex;neocortical;Neurons;neurophysiology;neuropsychiatric disorder;oligodendrocyte-myelin glycoprotein;Oligodendroglia;Oligonucleotides;Output;Parvalbumins;Pathway interactions;Pattern;Physiology;Play;postsynaptic;preadolescence;Predisposition;prevent;Process;Pyramidal Cells;rapid growth;Research Design;response;Role;Sensory;sensory cortex;Shapes;signal processing;Signal Transduction;Site;Somatostatin;targeted treatment;Testing;therapy design;Time

PROJECT_TITLE: Providing New Insight Into Adolescent Dendritic Development

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Data Science;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HOUGHTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: MICHIGAN TECHNOLOGICAL UNIVERSITY

PHR: PROJECT NARRATIVE Coronary revascularization (CR) is a common heart procedure used to treat patients with severe coronary artery disease. This research project aims to combine information about the heart muscle and arteries before the CR to improve treatment decisions. It not only helps doctors make better choices about how to perform the procedure but also introduces translational cardiology to the students at Michigan Tech, which will connect the university's engineering research with clinical practice.

PI_NAMEs: ZHOU, WEIHUA  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: 3-Dimensional;Advocate;Algorithms;Anatomy;Angiography;Arteries;Cardiology;Clinical;clinical application;clinical decision support;clinical decision-making;clinical practice;Clinical Research;clinical translation;convolutional neural network;Coronary;Coronary Angiography;Coronary Arteriosclerosis;Coronary artery;Coronary Stenosis;Data;deep learning;digital;Education;Engineering;Exposure to;graph neural network;Heart;Image;image processing;improved;improved outcome;Individual;innovation;Interdisciplinary Study;Intervention;Learning;Left ventricular structure;Lesion;Machine Learning;machine learning method;Maps;Medical;Medical Imaging;Medical Informatics;medical schools;Methods;Michigan;Modeling;Motion;multimodal fusion;Multimodal Imaging;Myocardial;Myocardial perfusion;Myocardium;Outcome;Patient Selection;Patients;Performance;Perfusion;perfusion imaging;Physiological;Procedures;programs;Psychological reinforcement;reconstruction;Reproducibility;Research;Research Project Grants;revascularization;Right ventricular structure;Semantics;Side;simulation;single photon emission computed tomography;software systems;Stenosis;Students;Techniques;Technology;technology development;Time;Translational Research;Trees;Uncertainty;undergraduate student;Universities;Validation;Work

PROJECT_TITLE: Multi-modality Image Fusion to Improve Coronary Revascularization in Patients with Stable Coronary Artery Disease

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetic Testing;Genetics;Human Genome;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative  A significant proportion of individuals who undergo genetic testing receive an inconclusive diagnosis and a subset of which could be attributed to the technical limitations of short-read sequencing. We propose to address the shortcomings of the current technologies by developing a long-read sequencing assay to resolve inconclusive diagnoses and reduce the uncertainty in genetic test results. Our studies will provide new insights on the additional diagnostic yield from resolving prior inconclusive results and demonstrate the clinical utility of long-read sequencing as a comprehensive assay for rare Mendelian disorders.

PI_NAMEs: RAJAGOPALAN, RAMAKRISHNAN  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Address;Adoption;autosome;Bioinformatics;Biological;Biological Assay;Caring;Categories;Childhood;Classification;Clinical;clinical care;cohort;Data;de novo mutation;Diagnosis;Diagnostic;diagnostic value;Disease;disease-causing mutation;Dominant Genes;Environment;Epigenetic Process;Equity;exome;exome sequencing;experience;experimental study;Failure;falls;follow-up;Generations;Genes;Genetic;Genetic Diseases;genetic disorder diagnosis;genetic testing;genetic variant;Genome;genome sequencing;genome-wide;genome-wide analysis;Genomics;Goals;imprint;improved;Individual;Infrastructure;insight;Institution;Knowledge;Laboratories;Mendelian disorder;Methods;Methylation;Molecular Diagnosis;Parents;Pathogenicity;Patients;pediatric patients;Performance;Phase;Positioning Attribute;prevent;rare mendelian disorder;Recessive Genes;Research;Resolution;Resources;Sampling;standard of care;Technology;Test Result;Testing;Time;Uncertainty;Variant;variant detection;variant of unknown significance;whole genome;Work

PROJECT_TITLE: Utilizing long-read sequencing to resolve inconclusive diagnoses and uncertainty in genetic testing

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (O2)]


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Human listeners can utilize the brain’s high spatial sensitivity to localize and separate multiple sound sources in a noisy environment. The project aims to explore biologically inspired algorithms that enable sound localization and speech segregation in hearing devices.

PI_NAMEs: GAI, YAN  (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: 3-Dimensional;3D Print;Acoustics;Agreement;Algorithms;Area;Attenuated;Award;Back;Behavior;Binaural;binaural hearing;Biomedical Engineering;blind;Brain;Classification;Communication impairment;Computer Assisted;Computer software;Cues;Data Analyses;Databases;design;Detection;Development;Electrical Engineering;Engineering;engineering design;Environment;experience;experimental study;Foundations;Frequencies;Future;Goals;Head;Healthcare;Hearing Aids;hearing impairment;Human;improved;innovation;instrumentation;interest;Knowledge;Learning;Location;Machine Learning;Maps;Masks;Measures;microphone;Mission;Modeling;Modernization;National Institute on Deafness and Other Communication Disorders;next generation;Noise;normal hearing;open source;Persons;Property;Psychophysics;Real-Time Systems;Running;segregation;signal processing;Signal Transduction;simulation;skills;sound;sound frequency;Sound Localization;Source;source localization;Speech;Speech Intelligibility;Speech Perception;speech recognition;Strategic Planning;Students;System;Technology;Testing;Time;two-dimensional;undergraduate student;Universities;Work;Writing

PROJECT_TITLE: Speech Localization and Enhancement for Next-Generation Hearing Devices


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Dissemination and Implementation Research;Infectious Diseases;Microbiome;Patient Safety;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Antibiotic resistance and healthcare-associated infections are major threats to human health and are a top public health priority. This proposal will support mentoring of the next generation of investigators who will advance the science of infection prevention and protect vulnerable populations, including children, from the impact of emerging antibiotic resistance.

PI_NAMEs: MILSTONE, AARON M (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Advisory Committees;Antibiotic Resistance;Antibiotics;Area;Award;Biometry;career;career development;Centers for Disease Control and Prevention (U.S.);Child;Child health care;Childhood;Clinical;cohort;Collaborations;Communicable Diseases;Contracts;Dedications;Diagnostic;emerging antibiotic resistance;Epidemiologist;Epidemiology;Faculty;Funding;Genomics;Goals;Health;health equity;Health Sciences;Healthcare;healthcare-associated infections;Hospitals;Human;implementation science;Inequity;Infection;Infection prevention;infection risk;Intervention;K-Series Research Career Programs;Knowledge;knowledge base;Laboratories;Learning;Manuscripts;marginalization;medical schools;member;Mentors;Mentorship;microbiome;microbiome research;microbiota transplantation;Mid-Career Clinical Scientist Award (K24);Modeling;nasal microbiome;Neonatal;New Agents;next generation;Nose;novel;Observational epidemiology;Organism;Paper;Parents;patient oriented;patient oriented research;Patients;Physicians;Population;Postdoctoral Fellow;pre-doctoral;prevent;Prevention;Productivity;programs;public health priorities;Recording of previous events;recruit;Research;Research Personnel;Research Support;Resistance;Resistance to infection;Resources;Sampling;Science;Sepsis;Societies;sociodemographic group;Source;Staphylococcus aureus;Testing;Time;Training;Training Programs;Translating;transmission process;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Mentoring in prevention of healthcare-associated infections and antibiotic resistance

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Improving screening and early detection is crucial for reducing the growing burden of cancer in our society. Such efforts have the potential to reduce cancer disparities and inequities if research is designed and conducted with equity and accessibility in mind. For the Cancer Screening Research Network, the Siteman Cancer Center Catchment Hub is focused on building equity in cancer screening through research and engaging diverse community members across Missouri and Illinois in this effort. Our multi-disciplinary team and region-wide partners are committed to reducing the burden of cancer for all.

PI_NAMEs: JAMES, AIMEE S (contact);PARK, YIKYUNG ;TORIOLA, ADETUNJI T

PROGRAM_OFFICER_NAME: LEEVAN, ELYSE MICHELLE

PROJECT_TERMS: Academic Medical Centers;acceptability and feasibility;Adoption;Adult;Area;Cancer Burden;Cancer Center;Cancer Control;Cancer Detection;cancer health disparity;career;Clinical;clinical care;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community advisory board;community center;community engagement;Community Health;Community Healthcare;community partners;Comprehensive Cancer Center;County;Data;Data Collection;Data Coordinating Center;data quality;data sharing;Dedications;design;detection test;Development;Diagnostic;Disparity;Early Diagnosis;Early treatment;economic disparity;Economics;Eligibility Determination;Enrollment;Ensure;Equity;equity, diversity, and inclusion;Ethnic Origin;Ethnic Population;evidence base;experience;follow-up;future implementation;health equity;Health equity research;health inequalities;Health system;Healthcare Systems;Home;Illinois;implementation science;improved;Incidence;Income;Individual;Inequity;Infrastructure;innovation;Institution;Insurance;Lead;Leadership;Low income;Lung;lung cancer screening;Malignant Neoplasms;marginalization;marginalized population;Medical;medical schools;Medical Technology;medically underserved;medically underserved population;member;Mind;Missouri;Monitor;Morbidity - disease rate;mortality;Multicenter Trials;multidisciplinary;National Cancer Institute;Organizational Affiliation;Outcome;Ovarian;Pancreas;Participant;participant enrollment;Pathway interactions;Patient Recruitments;Patients;Population;Population Heterogeneity;Positioning Attribute;Poverty;Prevention;Procedures;Protocols documentation;Race;racial diversity;racial population;recruit;Research;Research Design;Research Infrastructure;Research Personnel;Research Support;Resources;Rural;rural area;Rural Community;Science;screening;Screening for cancer;screening guidelines;Site;Societies;sound;statistics;Structure;success;Technology;Testing;Time;trial design;Underrepresented Populations;underserved community;Underserved Population;Uninsured;Universities;Urban Community;Washington;Work

PROJECT_TITLE: Building equity in cancer screening through research: The Siteman Catchment CSRN Hub

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (O1)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Pediatric;Rare Diseases;Regenerative Medicine

ORG_CITY: ALPHARETTA

ORG_NAME: ANNOVIANT, INC

PHR: Congenital heart disease (CHD) is a condition that affects a significant number of newborns each year, with approximately 40,000 cases in the USA and 1.35 million globally. Valve and conduit replacements are required for repairing or replacing right ventricle outflow tract (RVOT) defects associated with CHD. This is necessary for defects such as absent pulmonary valve, aortic stenosis (Konno procedure, Ross procedure), double outlet right ventricle (Rastelli operation), extracardiac conduit, and pulmonary valve replacement (Tetralogy of Fallot). Unfortunately, the current replacement device materials are suboptimal and have a high failure rate, requiring reoperations in pediatric and adult patients. This research proposal aims to commercialize a breakthrough TxGuardTM pulmonary-valved graft (PVG) device that is designed to resist early degeneration and allow for regeneration with host cells, ensuring that the device grows with the pediatric patient. The proposed Phase IIB SBIR grant will help to de-risk several critical aspects of the research and complete pre-clinical test data required for FDA humanitarian device exemption (HDE) submission. Confidential Page 1 of 1

PI_NAMEs: HOUDE, AJAY  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acceleration;Acute;Address;Adult;Advanced Glycosylation End Products;Affect;Anastomosis - action;Aneurysm;Aortic Valve Stenosis;Area;Arteries;Award;Biocompatible Materials;biomaterial compatibility;Bioprosthesis device;Birth;Blood;Blood flow;calcification;Carbon Dioxide;Cardiac;Cattle;Cells;Cellular Infiltration;Childhood;Clinical;Collagen;commercialization;Congenital Abnormality;Congenital atresia of pulmonary valve;congenital heart abnormality;critical congenital heart disease;crosslink;cytotoxicity;Data;Defect;design;Development;Devices;Diagnosis;Distal;Double Outlet Right Ventricle;Drops;Electron Beam;Ensure;Extravasation;Failure;feasibility testing;Freezing;Funding;Glucose;Glutaral;Grant;Growth;Guidelines;Heart;hemocompatibility;high risk;homograft;Implant;implantable device;implantation;improved;In Vitro;in vivo;in vivo evaluation;Infection;infection risk;Inflammation;irritation;Label;Legal patent;Letters;manufacture;Marketing;Mechanics;Mediating;Metabolism;Methods;mortality;National Heart, Lung, and Blood Institute;Natural regeneration;New Device Approvals;Newborn Infant;non-Native;novel;operation;Outcome Study;Patients;pediatric patients;Performance;Pericardial body location;Persons;Phase;Polytetrafluoroethylene;Population;pre-clinical;Preclinical Testing;pressure;Prevalence;prevent;Procedures;Process;Property;prototype;Pseudoaneurysms;pulmonary valve replacement;Pulmonary valve structure;Pulsatile Flow;Quality of life;Reaction;reconstruction;regeneration potential;regenerative;repaired;Repeat Surgery;Reporting;Reproducibility;Research;Research Proposals;Resistance;Right ventricular structure;Risk;sheep model;Shipping;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Stenosis;Sterility;Sterilization;Structure;Structure of jugular vein;System;systemic toxicity;Technology;Testing;Tetralogy of Fallot;thrombogenesis;Thrombosis;Tissues;Transposition of Great Vessels;Truncus Arteriosus;United States National Institutes of Health;valve replacement;Ventricular;viscoelasticity

PROJECT_TITLE: Pulmonary Valved Graft with Regeneration Potential for Pediatric Patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (O1)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The proposed research is relevant to public health because it seeks to improve our fundamental knowledge about the disease-causing transporter Sialin and develop a new strategy to rescue dysfunctional pathogenic Sialin mutations. The results will have the potential for future pharmaceutical development to treat related human diseases, such as free sialic acid storage disorder, heart failure, and even Parkinson’s. Thus, the proposed research is relevant to NIH’s mission.

PI_NAMEs: ZHENG, HONGJIN  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Aspartate;autosome;Biochemical;Biochemistry;Biological Assay;Biological Markers;Biophysics;Blood;Cardiac;Cardiomegaly;Cardiovascular Diseases;Cell membrane;Cells;Cellular biology;Chronic;Computational Biology;Coronary heart disease;Cryoelectron Microscopy;Cytosol;Data;design;Development;Disease;DNA Sequence Alteration;drug development;effective therapy;Energy-Generating Resources;Foundations;Functional disorder;Future;Genes;Glutamates;Goals;Heart;Heart Abnormalities;Heart Diseases;Heart failure;heart function;Hereditary Disease;high throughput screening;Human;human disease;human induced pluripotent stem cells;Impairment;improved;In Vitro;innovation;insight;interdisciplinary approach;Knowledge;Lysosomal Storage Diseases;Lysosomes;Maps;Membrane Transport Proteins;Metabolic;Mission;Molecular;molecular dynamics;mutant;Mutation;N Domain;N-acetylaspartylglutamate;Names;Nerve Degeneration;Nitrates;Outcome Study;Parkinson Disease;particle;Pathogenicity;Patients;Pharmacologic Substance;Predisposition;Public Health;Reporting;Research;Research Proposals;Resolution;Role;sialic acid permease;Sialic Acids;small molecule;solute;stem cell biology;structural biology;Structure;Structure-Activity Relationship;Synaptic Vesicles;Therapeutic;United States National Institutes of Health;uptake

PROJECT_TITLE: Mechanistic studies of human transporter Sialin

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cachexia;Cancer;Genetics

ORG_CITY: ROCHESTER

ORG_NAME: OAKLAND UNIVERSITY

PHR: Narrative Skeletal muscle wasting during cancer cachexia has been long deemed to be a mere reflection of overall body degradation. Challenging this assumption, we generated a mouse model that phenocopied cancer cachexia from within the skeletal muscle by impairing ribosome biogenesis, the synthesis of new ribosomes, specifically in skeletal muscle. This proposal seeks to determine the etiology of cancer cachexia by interrogating this intrinsic mechanism in skeletal muscle that leads to muscle wasting and cachectic phenotype.

PI_NAMEs: FIGUEIREDO, VANDRE CASAGRANDE (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Ablation;Actins;Activin Receptor;Address;Adipose tissue;Adult;Advanced Malignant Neoplasm;Affect;Atrophic;Attention;Biogenesis;Cachexia;Cancer Cachexia;Cancer Etiology;Cancer Model;Cancer Patient;cancer survival;cellular targeting;chemotherapy;Clinical Research;Data;density;Down-Regulation;Enterobacteria phage P1 Cre recombinase;Etiology;experimental study;extend lifespan;Fiber;Gastrocnemius Muscle;GDF8 gene;Genetic Transcription;Health;Human;Hypertrophy;Impairment;improved;improved outcome;Injections;Investigation;Knock-out;Link;Long-Term Effects;LoxP-flanked allele;Maintenance;Messenger RNA;Metabolism;mortality;mouse model;Mouse Strains;Mus;Muscle;muscle form;muscle hypertrophy;Muscular Atrophy;novel;old mice;Outcome;Pharmaceutical Preparations;Phenocopy;Phenotype;Play;Process;Prognosis;promoter;Protein Biosynthesis;Quality of life;Regulation;respiratory;Reverse engineering;Ribosomal DNA;Ribosomes;Role;Seminal;Signal Transduction;skeletal;Skeletal Muscle;skeletal muscle wasting;Soleus Muscle;survivorship;Symptoms;Syndrome;Systemic disease;Tamoxifen;Testing;therapeutic target;Time;transcription factor;transcription factor UBF;transcriptome;tumor;Tumor Volume;Work

PROJECT_TITLE: Reverse engineering cancer cachexia: muscle ribosome biogenesis in the etiology of cachexia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SMEP-C (80)]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Rural Health;Stroke

ORG_DEPT: NEUROLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Stroke remains a leading cause of death and disability in the US, with the situation particular severe in southeastern states like North Carolina and Virginia. Stroke Net’s goal is to maximize efficiencies for developing, promoting, and conducting high-quality, multi-site clinical trials focused on promising interventions for stroke prevention, treatment, and recovery. The ENVISION Regional Coordinating Center brings two major academic institutions, Duke and UNC, along with over a dozen suburban and rural regional hospitals in eastern North Carolina and southern Virginia to form a large-scale Regional Coordinating Center to enroll and retain a diverse stroke population in stroke clinical trials and to contribute to the overall success of StrokeNet.

PI_NAMEs: FENG, WUWEI  (contact);HWANG, DAVID YI-GIN;LIMKAKENG, ALEXANDER TAN

PROJECT_TERMS: Acute;Address;Adherence;Admission activity;Adult;Advocate;Alzheimer's Disease;Animal Experimentation;Articulation;Blood Vessels;career development;Caring;Catchment Area;Caucasians;Cause of Death;Cavernous Hemangioma;Cavernous Malformation;Cerebral hemisphere hemorrhage;child services;Childhood;Clinical;Clinical and Translational Science Awards;clinical infrastructure;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communication;Communities;community engaged research;community engagement;Community Hospitals;curriculum development;data quality/integrity;Dedications;Development;disability;Education Projects;Emergency Medicine;Enrollment;Ensure;Environment;Equity;experience;Fellowship;Fellowship Program;follow-up;Foundations;Funding;General Population;Goals;Grant;health disparity;health equity;Hospitals;improved;Institution;Interdisciplinary Study;International;Ischemic Stroke;Leadership;Letters;Mentors;mortality;Multi-Institutional Clinical Trial;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;Neurology;neurosurgery;next generation;North Carolina;operation;Outcomes Research;Participant;Patients;Pediatric Hospitals;Physicians;Physicians' Offices;Population;Population Heterogeneity;pre-clinical assessment;Prevalence;Prevention;Process;Productivity;programs;Protocols documentation;Publishing;Recording of previous events;Records;Recovery;recruit;Rehabilitation therapy;Research;Research Infrastructure;Research Personnel;research study;Resources;response;rural area;Scientist;Services;Site;skills;Stroke;Stroke Belt;stroke clinical trials;stroke education;stroke incidence;stroke intervention;stroke outcome;stroke patient;Stroke prevention;stroke recovery;stroke trials;StrokeNet clinical trials;StrokeNet trials;suburb;success;Talents;Teacher Professional Development;telestroke;Training;Translational Research;trial design;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Virginia;working group

PROJECT_TITLE: Duke-University of North Carolina (UNC) Eastern North Carolina and Southern Virginia RegIonal Stroke trIal cONsortium (ENVISION)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (17)]


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: NARRATIVE  The amount of LDL receptor expressed in a person’s liver is a major determinant of his or her lifetime risk of atherosclerotic diseases such as heart attack and stroke. This proposal seeks to define a specific region of the noncoding genome that controls LDL receptor expression and that may be targeted as a novel strategy to prevent and treat atherosclerotic disease.

PI_NAMEs: EMMER, BRIAN T (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Affinity Chromatography;Alleles;Atherosclerosis;atherosclerosis risk;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Biology;Biotinylation;Blood Circulation;candidate selection;cardiovascular disorder risk;Cell Line;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;CRISPR screen;Development;DNA-Binding Proteins;early onset;Engineering;Enhancers;Exhibits;Familial Hypercholesterolemia;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic variant;Genome;genome editing;genome wide association study;Genotype;Guide RNA;Hepatic;Human;Human Cell Line;Human Genetics;Human Genome;humanized mouse;in vivo;Individual;induced pluripotent stem cell;Inherited;internal control;Introns;Knowledge;LDL Cholesterol Lipoproteins;lifetime risk;Link;Lipoproteins;Liver;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Maps;Mediating;Metabolism;Molecular;Mus;Mutation;Myocardial Infarction;novel;novel strategies;novel therapeutics;Oligonucleotides;Oocytes;Organoids;Persons;pharmacologic;Physiological;Plasma;Play;Predisposition;prevent;receptor expression;Regulation;Regulatory Element;repaired;Reporter;Role;Sequence Homologs;Series;Signal Transduction;Single Nucleotide Polymorphism;Stroke;targeted treatment;Testing;therapeutic genome editing;transcription factor;Transcription Initiation Site;Untranslated RNA;Up-Regulation;uptake;Variant;Vertebrates;Work

PROJECT_TITLE: Molecular Regulation of LDL Receptor Expression

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Narrative  The goal is to develop an integrated deep learning model to optimize 5'UTR, codon usage, and 3'UTR at same time that enables users to design the optimal mRNA sequence to enhance protein expression level, thus to improve the efficacy of mRNA medicines. mRNA based therapies hold great promise for the treatment of various types of diseases, but this therapeutic approach suffers from multiple challenges including the short half- life of exogenously administered mRNA and subsequent protein production. Our proposed studies will address the challenges in design of mRNA sequence to enhance mRNA stability and translation efficiency, and thus provide important information for the development and optimization of mRNA vaccines.

PI_NAMEs: ZHOU, XIAOBO  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: 2019-nCoV;3' Untranslated Regions;5' Untranslated Regions;Affect;Antibodies;Antibody titer measurement;Antigen Targeting;Antigens;antiviral drug development;Atlases;Biology;booster vaccine;cell type;Cells;Clinical Trials;Codon Nucleotides;Communicable Diseases;conventional dosing;coronavirus pandemic;cost effective;COVID-19;COVID-19 pandemic;COVID-19 vaccine;Data;Data Set;deep learning;deep learning model;deep neural network;Dendritic Cells;design;Development;Disease;Dose;Ebola;Encapsulated;Equilibrium;FDA Emergency Use Authorization;Future;Genes;Genetic Diseases;Genome;Genotype-Tissue Expression Project;Globin;Goals;Half-Life;Hemoglobin;Human;Immune;Immune response;improved;in silico;In Vitro;in vivo;Individual;Infection;Infection prevention;Influenza;lipid nanoparticle;Malignant Neoplasms;manufacture;Medicine;Messenger RNA;Methodology;MicroRNAs;model design;Modeling;Moderna COVID-19 vaccine;mRNA Stability;mRNA Translation;Mutation;neutralizing antibody;Nonstructural Protein;novel;Open Reading Frames;Persons;Pfizer-BioNTech COVID-19 vaccine;Play;Poly(A) Tail;Production;prophylactic;protein expression;Proteins;Proteomics;Regimen;Reporting;Resistance;RNA vaccine;RNA Viruses;Role;Safety;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.617.2;SARS-CoV-2 genome;SARS-CoV-2 variant;Southern Africa;Speed;Structural Protein;Structure;Techniques;Testing;Therapeutic;Time;Tissues;Translating;Translations;United States;Untranslated Regions;Vaccinated;Vaccination;vaccine access;vaccine effectiveness;vaccine platform;Vaccines;Variant;Virus;Zika Virus

PROJECT_TITLE: Optimizing mRNA sequences with deep neural networks

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Genetics;Human Genome;Prevention

PHR: Project Narrative The current application will test the hypothesis that dysregulated Platelet Activating Factor (PTAF) and free fatty-acid (FFA) metabolism, via a novel epigenetic crosstalk featuring aberrant HNF4A transcription factor activation, is involved in growth dysregulation and early neoplastic evolution in cardia columnar cells at the human gastroesophageal junction (GEJ-cardia). This hypothesis will be tested by blocking the PTAF and FFA- HNF4A pathways, with lipidomic profiling in a human organoid model system and in human GEJ-cardia samples.

PI_NAMEs: LIN, DE-CHEN ;MELTZER, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: 3-Dimensional;Acids;Affinity;antagonist;ATAC-seq;Binding;Biological;Biological Assay;Biological Models;candidate validation;CDKN2A gene;Cell Proliferation;Cells;Cellular biology;ChIP-seq;Chromatin;Chromatin Conformation Capture and Sequencing;Columnar Cell;CRISPR/Cas technology;Detection;Differentiation and Growth;disease model;driving force;Dysplasia;Early Diagnosis;Early Intervention;Epigenetic Process;epigenome;epigenomics;Esophagogastric Junction;Etiology;Event;Evolution;Exhibits;experimental study;fatty acid metabolism;FDA approved;gain of function;Genetic;Genetic Transcription;genome editing;Growth;Histopathology;HNF4A gene;Human;Human Biology;Image;improved;in vivo;insight;Intestines;Investigation;knock-down;Knock-out;Lauric Acids;Lesion;Ligands;lipid metabolism;lipidomics;Lipids;Luciferases;mass spectrometric imaging;Measures;Metabolic;Modeling;Molecular;Morphology;Mus;Neoplasms;neoplastic;Neoplastic Cell Transformation;Nonesterified Fatty Acids;novel;Oleic Acids;Organoids;Palmitates;Pathway interactions;Patients;pharmacologic;Phenotype;Platelet Activating Factor;preventive intervention;prognostication;Proliferating;Proteins;Regulation;Reporter;Role;Sampling;Signal Transduction;small molecule inhibitor;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stearic Acids;stomach cardia;Testing;theories;Tissues;TP53 gene;transcription factor;Validation;Xenograft procedure

PROJECT_TITLE: Modeling Pathways of Early Growth Dysregulation at the GEJ

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Stroke is a disabling, often fatal and expensive disorder that is a major public health burden, and is the fourth most common cause of death in the United States. The operation of a successful regional stroke research consortium that includes diverse hospitals and multidisciplinary clinicians facilitates the ability to perform clinical trials examining promising new therapies for stroke prevention, treatment and recovery among adults and children.

PI_NAMEs: CUCCHIARA, BRETT LEE;KASNER, SCOTT E (contact)

PROJECT_TERMS: Academic Medical Centers;Adult;Age;Area;Blood Vessels;career;Cause of Death;Cerebrovascular Disorders;Child;Childhood;Clinical;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;Communication;Conduct Clinical Trials;Data Collection;data exchange;data management;Development;Disabling;Discipline;Disease;Education;Eligibility Determination;Emergency Department Physician;Enrollment;Ensure;ethnic diversity;experience;Feedback;follow-up;Fostering;Funding;Future;Generations;Geography;Goals;Hospitals;human subject protection;Infrastructure;innovation;Institution;K-Series Research Career Programs;Knowledge;Leadership;member;Mentors;Mentorship;Mission;Monitor;multi-site trial;multidisciplinary;neonate;Neurologist;Neurosurgeon;novel therapeutics;Nurses;operation;Participant;participant enrollment;patient population;Patient Recruitments;patient retention;Patients;Pediatric Hospitals;Pennsylvania;Phase;Philadelphia;Population Heterogeneity;Prevention;Principal Investigator;Procedures;Productivity;programs;Protocols documentation;Public Health;racial diversity;Recovery;recruit;Rehabilitation therapy;Research;Research Personnel;Research Support;Resources;Scientist;Site;skills;Specialist;Stroke;stroke clinical trials;stroke intervention;stroke patient;Stroke prevention;stroke therapy;stroke trials;StrokeNet trials;Structure;suburb;Surgeon;synergism;Talents;tertiary care;Training;Translational Research;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Women's Health Research

ORG_CITY: FLUSHING

ORG_NAME: QUEENS COLLEGE

ORG_STATE: NY

PHR: NARRATIVE  The proposed research is highly relevant to public health as it aims to test whether lifting lighter weights close to muscular failure (or inability to perform another repetition) improves strength, muscle mass, and physical function in older adults. By making strength training more accessible and less challenging, this study aims to improve strength training participation, ultimately improving independence and function in aging adults.

PI_NAMEs: THOZHUTHUNGAL BALACHANDRAN, ANOOP BALACHANDRAN  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Adult;Adverse event;Affective;Age;Aging;American;career;college;College Preparation;community living;Data;Data Analyses;Educational Intervention;efficacy evaluation;Elderly;Exercise;Failure;falls;Fatigue;Fatty acid glycerol esters;Goals;Growth;Guidelines;human old age (65+);improved;Injury;innovation;Joints;Knowledge;lean body mass;Lifting;Light;Measures;Mechanical Stress;men;Mobility disability;Motor;Muscle;muscle form;muscle strength;novel;older adult;older men;older women;Outcome Assessment;Pain;Participant;Physical activity;Physical Function;Pilot Projects;prevent;programs;Protein Biosynthesis;Public Health;Randomized, Controlled Trials;Recommendation;recruit;Research;resistance exercise;response;Risk;Science;sedentary;Self Efficacy;Single-Blind Study;Sports Medicine;strength training;Testing;Training;Training Programs;university student;Walking;Weight;Woman;young adult

PROJECT_TITLE: Improving Strength Training in Older Adults

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The most common malignant brain tumor affecting children and adolescents is medulloblastoma. We will test the efficacy and safety of a novel small molecule inhibitor of Rac1 GYS32661 in cells and in mouse models of medulloblastoma. Our studies will lay the foundation for clinical trials of Rac1 inhibitors for the treatment of medulloblastoma.

PI_NAMEs: AYAD, NAGI G (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Adolescent;Affect;Aftercare;Animal Model;Animals;Antibodies;Apoptosis;Ataxia;Attenuated;Binding;Biological Assay;Brain;Breast Cancer Cell;CASP3 gene;Cell Cycle;Cell Cycle Progression;cell motility;Cell Nucleus;Cell Proliferation;Cell-Cell Adhesion;Cells;Cerebellum;Child;Clinical Trials;Cognitive;Colorectal Cancer;Complex;Cytoskeleton;Data;Development;Disease;Dissociation;Dose;efficacy testing;Epigenetic Process;epigenetic regulation;Family;Foundations;Gene Expression Profile;Genetic;GLI gene;GLI2 gene;Growth;Guanosine Triphosphate Phosphohydrolases;Hematoxylin and Eosin Staining Method;Immunofluorescence Immunologic;Immunoprecipitation;In Situ Nick-End Labeling;In Vitro;in vivo;Incidence;inhibitor;Laboratories;Ligation;Luciferases;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Mediator;Medicine;Medulloblastoma;migration;Modeling;Monitor;Monomeric GTP-Binding Proteins;mouse model;Mus;Neurologic Deficit;Neurosphere;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Play;Proliferating;Recurrence;Regulation;Reporter;Reporting;resistance mechanism;rho;Role;Safety;SHH gene;Signal Transduction;small molecule inhibitor;smoothened signaling pathway;Stains;standard of care;System;Testing;therapeutic target;Toxic effect;traditional therapy;transcription factor;transcriptome sequencing;treatment group;tumor;tumor growth;Visualization

PROJECT_TITLE: Rac1 Inhibition for the treatment of medulloblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCTC-S (01)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Rehabilitation

ORG_CITY: GLASSBORO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ROWAN UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative The development of the proposed virtual reality (VR) parent training tool maximizes the effect of critically needed parent training for parents of children with autism spectrum disorder (ASD) who engage in severe destructive behavior. The VR training tool addresses access barriers to training by allowing parents to practice intervention implementation in the comfort of their own home at times convenient for their schedule and quality barriers by more closely resembling scenarios parents encounter with their own child than contrived practice opportunities. The proposed customizable VR technology has the potential to (a) be highly impactful for parents by teaching sustainable strategies for managing destructive behavior at home, (b) be efficient and informative for clinicians to collect data to support parents, and (c) mitigate the reoccurrence of destructive behavior by allowing parents to practice implementing intervention during treatment challenges.

PI_NAMEs: SIMMONS, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Address;Adherence;Aggressive behavior;Area;autism spectrum disorder;autistic children;Behavior;Behavioral;caregiver education;Caregivers;Caring;Child;Child Care;Community Integration;Control Groups;cost;cost effective;cost effectiveness;Data;design;Development;Devices;disability;dynamic system;Education;Educational process of instructing;efficacy evaluation;Emotional Stress;Environment;Evaluation;Exhibits;experience;Exposure to;Family;Financial Hardship;flexibility;Goals;Health Services Accessibility;Home;Home environment;implementation intervention;improved;improved outcome;individualized feedback;individuals with autism spectrum disorder;Injury;Intervention;Learning;Medical;method development;Modeling;novel;Outcome;parenting intervention;Parents;Participant;Patient Self-Report;Personal Satisfaction;Persons;Pilot Projects;pilot test;pilot trial;portability;Procedures;Process;programs;Property;prototype;Randomized;Recommendation;Records;Recurrence;Relapse;Reporting;response;Risk;Role playing therapy;satisfaction;Schedule;Self-Injurious Behavior;skill acquisition;skills;social;Social isolation;standard of care;Stress;Technology;Testing;Time;tool;Training;Training Programs;Transportation;treatment effect;usability;virtual reality;Visit;Work

PROJECT_TITLE: Randomized Pilot Evaluation of a Virtual Reality Parent Training Program for Severe Behavior in Children with Autism

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Rural Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE We propose to leverage our cumulative expertise in cancer screening and the resources of the University of North Carolina, UNC Lineberger, UNC Health, and Federally Qualified Health Centers (FQHCs) to create an ACCESS Hub in the new NCI Cancer Screening Research Network (CSRN). Our catchment area serves the entire state of North Carolina, offering a patient population that spans urban and rural locations, varied socioeconomic levels, and racial and ethnic diversity similar to the southeastern US population as a whole. In addition to capacity building and participation in the initial pilot feasibility study of multi-cancer early detection screening (Vanguard), we also propose exploratory qualitative research into perspectives of diverse communities regarding MCD screening that will inform future studies.

PI_NAMEs: HENDERSON, LOUISE ;LEE, CARRIE B;REULAND, DANIEL S. (contact)

PROJECT_TERMS: Acceleration;Address;African American;American Indian community;American Indian Population;Benefits and Risks;Black race;Blood;Cancer Center;Cancer Detection;cancer site;cancer type;Catchment Area;cell free DNA;Cessation of life;Clinical;clinical practice;Clinical Research;Clinical Trials;Collaborations;Communities;community advisory board;Comprehensive Cancer Center;concept mapping;Conduct Clinical Trials;Data;data management;Decision Making;Detection;detection assay;detection test;Development;Early Diagnosis;Eligibility Determination;Enrollment;Ensure;ethnic diversity;Ethnic Origin;Evaluation;evidence base;experience;Feasibility Studies;feasibility trial;Federally Qualified Health Center;Focus Groups;Funding;Future;Geography;Goals;Health;Health system;Hispanic;improved;Infrastructure;innovation;instrument;Malignant Neoplasms;Medical;member;Methods;mortality;multidisciplinary;National Cancer Institute;North Carolina;novel;novel strategies;Organizational Affiliation;Outcome;Participant;Patient Care;Patient Outcomes Assessments;patient population;Patients;Policies;Population;population based;Population Heterogeneity;Positioning Attribute;Primary Care;Protocols documentation;psychologic;Qualifying;Qualitative Research;Race;racial diversity;recruit;Registries;Research;Research Infrastructure;Research Personnel;Resources;Rural;rural area;Scientist;screening;Screening for cancer;Site;socioeconomics;Specific qualifier value;Technology;Testing;Underrepresented Populations;Universities;University resources;urban area;Voice

PROJECT_TITLE: Cancer Screening Research Network - North Carolina Hub (CSRN-NC HUB)


NIH_SPENDING_CATS: Neurosciences

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE A mechanistic understanding of oligodendrocyte development and myelin repair after injury will shed light on cellular vulnerability to white matter injury. In this proposal, we will define new genes and pathways that drive stage-specific oligodendrocyte lineage development and myelin repair via Wnt signaling, and pinpoint potential targetable pathways for therapies that can stimulate remyelination in white matter disorders.

PI_NAMEs: LEE, HYUN KYOUNG  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Acceleration;Address;Adverse event;Affect;Attenuated;Biochemical;casein kinase II;Cells;clinical application;Complex;Data;Development;Disease;Ectopic Expression;Exhibits;Genes;Genetic;Genetic Models;Genetic Transcription;Goals;Grant;Health;Human;Impairment;Injury;insight;Knowledge;Lipids;Mediating;mimetics;Modeling;Modification;Molecular;Morphogenesis;mouse model;multiple omics;Mus;Myelin;Myelin Sheath;myelination;Neuroglia;Neurologic;Neurons;novel;novel therapeutic intervention;oligodendrocyte lineage;Oligodendroglia;Outcome;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;Play;Post-Translational Regulation;Proteins;Proteolysis;receptor;Regulatory Pathway;remyelination;repaired;Reporting;Role;screening;Testing;tissue repair;TRIM Motif;Ubiquitin;Ubiquitin-mediated Proteolysis Pathway;ubiquitin-protein ligase;Up-Regulation;white matter;white matter injury;WNT Signaling Pathway

PROJECT_TITLE: Deciphering the mechanisms of glia development and white matter injury

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: DALLAS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Biomolecular condensates are membrane-less intracellular assemblies that play fundamental roles in cellular organization, physiology, and pathology. The functions of biomolecular condensates are closely linked to their molecular content. By developing a novel genomics platform for spatially resolved profiling of molecular contents within the condensates, we will provide novel insights into human health and disease through the lens of biomolecular condensates.

PI_NAMEs: CHEN, HAIQI  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Adopted;Affect;Affinity;Aging;aging related;Binding;Binding Proteins;Biological;biological adaptation to stress;Biological Models;Biology;Cell Aging;Cell Fraction;Cell Nucleolus;Cell Nucleus;Cell Physiology;cell type;Cells;Chromatin;Communities;computational pipelines;computerized tools;Cytoplasm;Cytoplasmic Granules;Data;data acquisition;Data Analyses;design;Development;Disease;DNA;Engineering;Ensure;Environment;Epigenetic Process;epigenome;epigenomics;Eukaryotic Cell;Event;Fibroblasts;Gene Expression Regulation;Generations;genetic manipulation;Genome;Genomic Library;genomic platform;genomic tools;Genomics;Germ;Goals;Health;high throughput technology;High-Throughput Nucleotide Sequencing;histone modification;Housekeeping;Human;Hybrids;improved;In Situ;innovation;insight;Label;Lasers;lens;Link;Location;Machine Learning;Measurement;Membrane;Methods;Modality;Molecular;molecular imaging;Molecular Profiling;multimodality;nanobodies;next generation;Noise;novel;Nuclear;Organelles;Pathologic;Pathology;Physical condensation;Physiological;Physiology;Play;Post-Transcriptional Regulation;Process;Reaction;recruit;Regulatory Element;Research;Resolution;RNA;RNA metabolism;Role;sequencing platform;Signal Transduction;stress granule;submicron;Technology;Tissues;Tn5 transposase;tool;transcriptome;transcriptomics;uptake;Work

PROJECT_TITLE: Spatially Resolved Molecular Measurement of Biomolecular Condensates


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Neurosciences;Rehabilitation;Stroke

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Stroke is the second leading cause of death and a leading cause of major disability globally, and is becoming more frequent with the aging population. NIH Stroke Net is a network of clinical sites and experts across the country working together to develop and complete multi-site clinical trials, the final step in proving that new potential treatments will work, and to train the next generation of clinical researchers. The National Coordinating Center leads and manages this network to test new ways to treat, prevent, and aid in recovery and rehabilitation from stroke.

PI_NAMEs: BRODERICK, JOSEPH PAUL;KHATRI, POOJA  (contact)

PROGRAM_OFFICER_NAME: MCCARTHY, SEAN PATRICK

PROJECT_TERMS: Acute;Address;Advisory Committees;Advocacy;Age;aging population;Agreement;Ancillary Study;Applications Grants;Area;base;Biological Markers;biomarker validation;career development;Caring;Cause of Death;Cerebrovascular Disorders;Clinical;Clinical Investigator;clinical practice;Clinical Research;clinical research site;Clinical Trials;Collaborations;Communities;community partners;Conceptions;Continuing Education;Contracts;Country;COVID-19 pandemic;COVID-19 patient;Dedications;design;Development;Devices;disability;Education;Elderly;electronic consent;Enrollment;Ensure;equity, diversity, and inclusion;Ethnic Origin;experience;Feasibility Studies;Feedback;Funding;Gender;Grant;Hospitals;Image;improved;Incidence;industry partner;innovation;Institutional Review Boards;International;K-Series Research Career Programs;Leadership;member;Methodology;Minority Recruitment;Multi-Institutional Clinical Trial;multi-site trial;multidisciplinary;National Institute of Neurological Disorders and Stroke;next generation;novel strategies;Outcome;Participant;participant retention;patient population;Patient Representative;Patients;payment;Pediatrics;Pharmaceutical Preparations;Pharmacy facility;Phase;Population;Populations at Risk;pre-clinical;prevent;Prevention;Process;Professional Education;Race;Recovery;recruit;Rehabilitation therapy;Research;Research Personnel;Resources;SARS-CoV-2 infection;Science;Series;sex;Site;Standardization;Stroke;stroke rehabilitation;stroke trials;StrokeNet trials;symposium;telerehabilitation;Testing;thrombotic;timeline;Training;Training and Education;trial design;United States National Institutes of Health;Universities;validation studies;Work;working group;Working stroke

PROJECT_TITLE: NIH StrokeNet National Clinical Coordinating Center (NCC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (16)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE (from parent grant) Pancreatic ductal adenocarcinoma (PDA) can be classified into quasi-mesenchymal (QM) and classical subtypes, but the genetic or epigenetic mechanisms driving subtype determination in PDA remain poorly understood. Our preliminary data suggests that loss of the histone deacetylase and PDA tumor suppressor gene Sirtuin 6 (SIRT6) may act an epigenetic switch that drives the more aggressive QM phenotype, while at the same time rendering PDA cells highly dependent on a specific targetable pathway. This proposal aims to elucidate mechanisms of SIRT6 downregulation in QM PDA, explore SIRT6 as a critical regulator of PDA subtype determination, and leverage this knowledge for the preclinical development of novel targeted therapies in this disease.

PI_NAMEs: KUGEL, SITA  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Automobile Driving;Binding;Biological Markers;cancer cell;Cancer Etiology;cancer subtypes;Cell Line;ChIP-seq;Classification;Clinical;Combination Drug Therapy;Coupled;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinases;Cytogenetics;Data;Dependence;Development;Disease;Dose;Down-Regulation;drug discovery;Drug resistance;drug sensitivity;Endocrine;Enhancers;Epigenetic Process;gain of function;Gene Expression Profile;Genes;Genetic;genetic signature;Genetic Transcription;Genetically Engineered Mouse;Genomics;Goals;HDAC4 gene;High-Throughput Nucleotide Sequencing;Histone Deacetylase;Human;immunogenic;improved;in vitro activity;Individual;Induction of Apoptosis;inhibitor;innovation;insight;Intervention;knock-down;Knowledge;KRAS oncogenesis;KRAS2 gene;loss of function;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mesenchymal;Messenger RNA;MicroRNAs;Modeling;Molecular;mortality;MYC gene;neoplastic cell;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;parent grant;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Pharmacologic Substance;Phenotype;Phosphotransferases;precision medicine;preclinical development;predictive marker;Primary Neoplasm;progenitor;Prognosis;programs;Proteins;repository;Resistance;Role;Sampling;Sirtuins;Specificity;standard of care;targeted treatment;Therapeutic;Time;transcriptome sequencing;transcriptomics;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;United States;Work;Xenograft procedure

PROJECT_TITLE: Exploring the epigenetic control of pancreatic cancer subtypes


ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative IL-1α exhibits dual functionality, acting as a traditional cytokine but also controlling a number of diverse cellular functions. We will interrogate the mechanism by which IL-1α is released from dying cells and its modulation of innate immune responses through the regulation of efferocytosis and mitophagy. We will further determine if IL-1α-mediated stromal cell crosstalk and interference with cellular eat-me signals modulates inflammation and pathology induced by a sterile inflammatory insult.

PI_NAMEs: DAGVADORJ, JARGALSAIKHAN ;SUTTERWALA, FAYYAZ S. (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: Acceleration;Alveolar Macrophages;Apoptosis;Apoptotic;Autophagocytosis;Binding;Binding Sites;Biology;Calpain;Cardiolipins;CASP1 gene;CASP3 gene;Cell Death;cell growth regulation;cell injury;Cell membrane;Cell Physiology;Cell surface;Cells;Chemotactic Factors;Choristoma;CXCL1 gene;cytokine;Data;Down-Regulation;Eating;Epithelial Cells;epithelial injury;Excision;Exhibits;Failure;Fibroblasts;IL1R1 gene;Immune;Impairment;In Vitro;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;insight;interest;Interleukin-1;Interleukin-1 alpha;Interleukin-1 beta;Knowledge;Lipids;Lung;Macrophage;Masks;Mediating;member;Membrane;Membrane Lipids;Mitochondria;mitochondrial dysfunction;Movement;mRNA Expression;Mus;Myelogenous;Natural Immunity;Necrosis;neutrophil;Neutrophil Infiltration;novel;Organ;Outer Mitochondrial Membrane;paracrine;Pathology;Pathway interactions;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylserines;phospholipid scramblase;Phospholipids;Physiological;Play;prevent;Process;Proteins;receptor;Regulation;response;Role;Signal Transduction;Silicon Dioxide;Site;Sterility;Stromal Cells;Surface;Testing;Wild Type Mouse;Work

PROJECT_TITLE: Regulation of cellular functions and innate immunity by interleukin-1alpha

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Hematology;Orphan Drug;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Hemophilia A is a bleeding disorder resulting from factor VIII (FVIII) deficiency. The development of inhibitory antibodies against FVIII is not only a severe and important complication of protein replacement therapy, but also a major concern in gene therapy of hemophilia A. In this project, we will develop a novel approach by targeting the synthesis of FVIII to blood platelets to provide therapeutic protein and induce immune tolerance in hemophilia A even in the presence of inhibitory antibodies.

PI_NAMEs: SHI, QIZHEN  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Address;Adult;Affect;aged;Alpha Granule;Animal Model;Antibodies;Antigens;Apoptosis;Automobile Driving;Biological;Biology;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Busulfan;Calpain;Carrier Proteins;CD8-Positive T-Lymphocytes;Cells;Circulation;Clinical;clinical translation;Clinical Trials;Clonal Deletion;Coagulation Process;Communities;Complex;Complication;conditioning;cytotoxic CD8 T cells;design;Development;DNA cassette;Docking;Effectiveness;effector T cell;Engineering;Engraftment;enzyme replacement therapy;Factor VIII;Failure;Fibrin;Funding;Gene Delivery;gene therapy;gene-targeted therapy;Generations;Genes;genotoxicity;Goals;Hematopoietic stem cells;Hemophilia A;Hemorrhage;Hemostatic function;Immune;Immune response;Immune Tolerance;Immunity;immunoregulation;Impairment;improved;inhibitor;Injury;innovation;Insertional Mutagenesis;Lentivirus;Lentivirus Vector;Liver;Liver diseases;Mediating;Megakaryocytes;Mus;next generation sequencing;Non-Steroidal Anti-Inflammatory Agents;novel strategies;Patients;Peptide Hydrolases;peripheral tolerance;Plasma;Platelet Activation;Platelet aggregation;platelet function;Population;preconditioning;Process;Production;promoter;Property;Proteins;Protocols documentation;Regimen;Regulatory T-Lymphocyte;Risk;Safety;Site;T cell response;Therapeutic;therapeutic protein;thrombotic;Time;Transfusion;Transplantation;Viral Vector;Virus Integration

PROJECT_TITLE: Platelet-derived FVIII Gene Therapy of Hemophilia A

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Lung;Lung Cancer;Mental Health;Mental Illness;Pain Research;Palliative Care;Prevention

ORG_CITY: DURHAM

ORG_STATE: NC

PHR: Project Narrative. Patients with metastatic lung cancer are living longer (i.e., metavivors), but they experience high psychological distress (i.e., depressive symptoms, anxiety, illness non-acceptance), persistent symptom burden (i.e., fatigue, dyspnea, pain), and poor overall quality of life. Given that existing psychosocial intervention paradigms are not designed to help metavivors navigate the emotional turbulence of living while dying, we created LiveWell, an 8- session adapted Dialectical Behavioral Therapy Skills Training protocol that teaches patients transdiagnostic, easy-to-use skills (e.g., mindfulness, distress tolerance, emotion regulation, interpersonal effectiveness) to enable them live as well as possible, with metastatic lung cancer. The proposed research enhances the health and quality of life of the growing number of lung cancer metavivors by addressing their unmet emotional needs and offers a promising psychosocial intervention paradigm for other groups of metavivors and patients living with chronic illness.

PI_NAMEs: HYLAND, KELLY ALEXANDRA (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adherence;Aftercare;Anxiety;arm;Behavior;behavior change;Behavior Therapy;behavioral clinical trial;Behavioral Model;Behavioral trial;Cancer Center;Cancer Intervention;Cancer Patient;Caring;Chest;Chronic Disease;Clinic;clinically significant;Consultations;coping;Data;depressive symptoms;design;Diagnostic;Disease;Disseminated Malignant Neoplasm;Distress;distress tolerance;Dose;Dyspnea;Educational Intervention;Educational process of instructing;Effectiveness;efficacy trial;emotion regulation;Emotional;emotional experience;evidence base;Evidence based treatment;experience;Face;Fatigue;Feasibility Studies;Feedback;follow-up;Funding;Future;Health;implementation framework;implementation science;improved;improved outcome;interest;Intervention;Interview;Leadership;Learning;Life;Malignant neoplasm of lung;Malignant Neoplasms;Mediation;member;Mental Depression;Mentors;Methods;mindfulness;model development;Monitor;novel;Oncologist;Outcome;Pain;Participant;Patients;Pattern;persistent symptom;Phase;pilot test;pilot trial;primary outcome;Procedures;Process;Protocols documentation;Provider;psychological distress;psychological symptom;psychosocial;Psychotherapy;Quality of life;Randomized;Randomized, Controlled Trials;Research;Research Personnel;response;Role;satisfaction;Scientist;secondary outcome;skills;skills training;Standardization;Survival Rate;sustainability framework;Symptom Burden;symptom management;Symptoms;telehealth;Testing;Therapeutic;therapy development;Thinking;Thoracic Oncology;Ticks;Time;Training;treatment as usual;treatment comparison;trial design;Uncertainty;videoconference;Work

PROJECT_TITLE: LiveWell: An Adapted Dialectical Behavioral Therapy Skills Training Protocol for Patients Living with Metastatic Lung Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (O1)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Urologic Diseases

PHR: PROJECT NARRATIVE The goal of the Vanguard phase of the Cancer Screening Research Network (CSRN) is to design and conduct a randomized controlled feasibility trial of two promising MCD tests. The CSRN Communication and Coordinating Center (CCC), in conjunction with the CSRN Statistics and Data Management Center (SDMC) and the NCI, will lead and support this critical national effort with exceptional scientific and clinical expertise, organizational and administrative infrastructure, effective communication, well-tuned recruitment and retention leadership and resources, and a comprehensive quality assurance program. The design of the Vanguard and future trials will be informed and extended by well-calibrated microsimulation modelling of cancer screening in at risk populations.

PI_NAMEs: ANDERSON, GARNET L. (contact);ETZIONI, RUTH D;RAMSEY, SCOTT D.

PROGRAM_OFFICER_NAME: LEEVAN, ELYSE MICHELLE

PROJECT_TERMS: Address;biobank;Breast;Calibration;Cancer Burden;cancer diagnosis;candidate selection;Catchment Area;Cervical;Clinical;Colorectal;Communication;Communities;Complex;cost;Data;Data Collection;Data Coordinating Center;design;Detection;detection assay;detection test;Development;Diagnostic Procedure;Documentation;Early Diagnosis;Ensure;Environment;Ethics;Evaluation;feasibility trial;follow-up;Frequencies;Future;Goals;Group Structure;Guidelines;health inequalities;Industry;Infrastructure;interest;Intervention;Language;Lead;Leadership;Learning;Liver;Malignant Neoplasms;Minority Groups;Modeling;models and simulation;Monitor;mortality;Nature;Observational Study;operation;organizational structure;Ovarian;Pancreas;Participant;patient population;Patients;Phase;Policies;Population;Populations at Risk;Procedures;Process;programs;Prostate;protocol development;Protocols documentation;Provider;quality assurance;Randomized;randomized trial;Readiness;recruit;Reporting;Research;Research Personnel;Resolution;Resources;routine screening;screening;Screening for cancer;Site;Specimen;statistics;Stomach;Structure;success;Technology;Testing;Time;timeline;Training;trial design;Underserved Population;web site

PROJECT_TITLE: NCI Cancer Screening Research Network: Coordinating and Communication Center


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative Malaria is a major impediment to the economic development in Myanmar, a country in the Greater Mekong Subregion of Southeast Asia, which has recently opened up during the democratization process. In this research training application, we propose to train a cadre of junior scientists from Myanmar to address important problems in malaria research, control, and elimination. Through long- and short-term training of endemic area scientists, this program will build the necessary capacity to ensure sustained interests in research and training on malaria in this region.

PI_NAMEs: CUI, LIWANG  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Accounting;Achievement;Address;Anti-malarials;Area;Artemisinins;Beds;Career Mobility;clinical efficacy;Country;design;Deterioration;Discipline;Disease;doctoral student;Educational workshop;Effectiveness;Ensure;Epidemiology;Faculty;Florida;Goals;Heterogeneity;innovation;Insecticide Resistance;Insecticides;Knowledge;Malaria;Measures;Medicine;member;Mentors;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Myanmar;Needs Assessment;Plasmodium falciparum;Plasmodium vivax;Postdoctoral Fellow;programs;Public Health;pyrethroid;Research;Research Personnel;Residual state;Resistance;resistance mechanism;Scientist;Southeastern Asia;Technical Expertise;Technology;Training;Training Programs;Universities;vector;vector control;vector mosquito

PROJECT_TITLE: Training in Malaria Research in Myanmar

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Z(55)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative  Plasticity is a critical property of the nervous system. In the case of movement, it helps to overcome persistent motor errors caused by growth, aging, injury, and disease. This proposed work represents the first concerted effort to understand an important form of neural plasticity, that is, motor adaption of internally driven movements.

PI_NAMEs: KOJIMA, YOSHIKO  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TITLE: Neural mechanisms of motor adaptation for an internally driven movement

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Cancer;Hematology;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE Anaplastic Large Cell Lymphoma (ALCL) is a T cell lymphoma frequently driven by chromosomal rearrangements involving the Anaplastic Lymphoma Kinase (ALK) gene. ALK inhibitors show potent activity in chemotherapy refractory ALCL, but resistance develops and lymphoma is never eradicated. We identified several molecular mechanisms that prevent eradication and propose to develop novel therapeutic strategies to overcome resistance and cure ALCL in most patients. ALK+ ALCL could become the first T cell lymphoma to be cured without chemotherapy by targeted therapy.

PI_NAMEs: CHIARLE, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: 3-Dimensional;Adult;Affect;ALK gene;anaplastic lymphoma kinase;Biology;Blood Vessels;Bypass;Cancer Patient;Candidate Disease Gene;CCL19 gene;Cells;chemokine receptor;chemotherapy;Child;Chromosomal Rearrangement;Chromosomal translocation;Clinical;Combined Modality Therapy;coping;crizotinib;Disease;Disease remission;Down-Regulation;experimental study;Family;FDA approved;Future;Generations;Genetic Screening;Genetic Status;Goals;Grant;Guanosine Triphosphate Phosphohydrolases;improved;In Vitro;in vivo;in vivo Model;inhibitor therapy;Ki-1 Large-Cell Lymphoma;kinase inhibitor;Lymphoma;Lymphoma cell;Lymphomagenesis;MAP Kinase Gene;Mediating;Modality;Modeling;Molecular;mouse model;Mus;Mutate;Mutation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;partial response;Pathway interactions;Patients;Pattern;Phase I/II Clinical Trial;phosphatidylinositol 3-kinase gamma;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;prevent;PTPN1 gene;PTPN11 gene;Recurrence;Refractory;Relapse;Resistance;Resistance development;resistance mechanism;response;rho;Role;Secondary to;Signal Pathway;Signal Transduction;standard of care;success;T-Cell Lymphoma;T-Lymphocyte Subsets;targeted treatment;Testing;Therapeutic;Toxicity due to chemotherapy;Tyrosine Kinase Inhibitor;young adult

PROJECT_TITLE: Mechanisms of resistance to ALK inhibitors in ALK-rearranged lymphoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Patient Safety;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This study will identify important patient-based emotional motivators of treatment decision making in breast cancer clinical care and test an innovative web-based shared decision engagement system for use by both breast cancer patients and their clinicians. The overall results of this intervention study will lay the groundwork for broad implementation of a shared decision engagement system to improve patient centered communication and decision making in breast cancer.

PI_NAMEs: HAWLEY, SARAH T (contact);JAGSI, RESHMA

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: Address;Algorithms;Anxiety;Area;Attitude;base;Benefits and Risks;breast cancer diagnosis;Breast Cancer Patient;Breast Cancer Treatment;Breast Oncology;breast surgery;Clinic;clinical care;Cluster randomized trial;Cognitive;cognitive task;Collaborations;Communication;Community Clinical Oncology Program;Complex;Consolidated Framework for Implementation Research;dashboard;Data;Decision Making;Diagnosis;Emotional;Emotions;experience;Feedback;Floods;Fostering;Future;future implementation;Health;improved;individualized medicine;information processing;innovation;Intervention;Intervention Studies;Knowledge;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mediator;Modality;Newly Diagnosed;Online Systems;Operative Surgical Procedures;Outcome;Outcome Measure;overtreatment;patient engagement;patient oriented;patient-clinician communication;Patients;precision medicine;primary outcome;process evaluation;programs;Quality of Life Assessment;Randomized, Controlled Trials;Recommendation;Reporting;Research;research clinical testing;response;secondary outcome;Self Efficacy;Self Management;Specialist;statistics;Surgical Oncology;Surveys;System;Testing;Time;tool;Translating;treatment risk;Work

PROJECT_TITLE: Improving Patient-Centered Communication in Breast Cancer: A RCT of a Shared Decision Engagement System (ShaDES)

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]