ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Diabetes;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PISCATAWAY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Diabetic retinopathy is the leading cause of blindness in working-age adults with more than 190 million worldwide projected to be affected by 2030. This project will develop a computer model to predict initiation and progression of diabetic retinopathy based on changes in blood flow in retinal vessels that are caused by changes in the properties of blood cells and vessel structure due to their prolonged exposure to diabetic conditions. The detailed and accurate prediction from this model may provide novel insights on blood flow-mediated pathogenesis of retinopathy, and reliable metrics for early disease detection, thereby directly benefiting clinical diagnosis and treatment.

PI_NAMEs: BAGCHI, PROSENJIT  (contact)

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Adult;Affect;Age;Appearance;Architecture;Biological Availability;biophysical properties;Biophysics;Blindness;Blood;Blood capillaries;Blood Cells;Blood flow;Blood Platelets;Blood Vessels;Blood Viscosity;Cells;Clinical;clinical diagnosis;Clinical Treatment;Complex;Computer Models;Coupling;Data;Detection;Development;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Diagnostic;Disease;Disease Progression;Endothelial Cells;endothelial dysfunction;Endothelium;Erythrocytes;Evaluation;Exposure to;Gases;Geometry;hemodynamics;Hemorrhage;Heterogeneity;Homeostasis;human imaging;Hypoxia;Image;Imaging Techniques;Impairment;in silico;in vivo;in vivo imaging;Individual;innovation;insight;Knowledge;Leukocytes;macula;Measurement;Mediating;Microaneurysm;Modeling;Morphology;multi-scale modeling;Nature;Nitric Oxide;novel;Oxidative Stress;Pathogenesis;Pathway interactions;predictive modeling;Progressive Disease;Property;Reactive Oxygen Species;Regulation;research clinical testing;Retina;retina blood vessel structure;Retinal Diseases;retinal imaging;Rheology;Role;Severity of illness;simulation;spatiotemporal;Structure;Study models;tissue oxygenation;Tissues;trafficking;Variant;vascular abnormality;Vasodilation;Virulence Factors;Visual

PROJECT_TITLE: Development and application of a high-fidelity computational model of diabetic retinopathy hemodynamics: Coupling single-cell biophysics with retinal vascular network topology and complexity


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE A devastating and deadly neurodegenerative disorder, Alzheimer's disease is a major health crisis that has its greatest impact on elderly populations and their caregivers; thus, identifying effective treatments that increase both the lifespan and healthspan of individuals who would otherwise succumb to the disease is a major goal of current research. Our experiments showing that decreased Kinesin-5 activity likely contributes to the pathology and symptoms of Alzheimer's disease is important to public health, as our findings reveal its potential as a novel target for developing therapeutic interventions. Identifying the cellular processes affected by changes in Kinesin-5 activity will lead to an increased understanding of neuronal processes in both diseased and non- diseased states, allowing the knowledge gained from our proposed project to be applied to studies of other neurological disorders beyond Alzheimer's disease.

PI_NAMEs: LUCERO, ESTEBAN M (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: abeta oligomer;Acute;Address;Admixture;Affect;aged;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;American;Amyloid;Amyloid beta-Protein;Animals;Architecture;ATP phosphohydrolase;Award;Behavioral;Biochemical;Biological Assay;Biological Models;Brain;BRAIN initiative;career;Caregivers;Cell Culture Techniques;Cell Physiology;clinically significant;Cognitive;conditioned fear;Defect;Dendritic Spines;density;Deposition;Depressed mood;Development;Disease;disease phenotype;Disease Progression;Doctor of Philosophy;effective therapy;Elderly;experimental study;Functional disorder;Genes;Genetic;Genetic Polymorphism;Genetic Predisposition to Disease;Goals;Grant;Haplotypes;Health;Healthcare Systems;healthspan;Hippocampus;improved;In Vitro;Individual;innovation;interest;Investigation;Kinesin;Knowledge;Latino Population;Leadership;Learning;life span;Link;Long-Term Potentiation;Measurement;Mediating;Memory;Memory impairment;Mentors;Mentorship;Microtubule Polymerization;Microtubules;Morphology;Motor;mouse model;Mus;Nervous System Disorder;neural;Neurites;Neurodegenerative Disorders;Neurons;Neurosciences;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;overexpression;Pathogenesis;Pathology;Patients;Pharmaceutical Preparations;Phenotype;Population;Postdoctoral Fellow;prevent;Prevention;Process;Proteins;Public Health;Research;Research Personnel;Research Project Grants;Role;Route;skills;Slice;small molecule;Symptoms;Testing;Therapeutic Intervention;therapeutic target;United States National Institutes of Health;Vertebral column;Wild Type Mouse;Work;Writing

PROJECT_TITLE: Understanding the role of genetic admixture on Alzheimer’s Disease risk in Latíno Populations


ADMINISTERING_IC: AR

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Comparative Effectiveness Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoarthritis;Precision Medicine;Prevention

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Arthroscopic partial meniscectomy provides no clinically meaningful benefits for certain patient groups even after physical therapy fails. Preoperative identification of this population can help substantially improve clinical treatment and management plans of these patients by reducing unnecessary surgeries and cost to the healthcare system. The proposed study will provide a novel outcome prediction model to achieve this goal by utilizing imaging findings from a deep learning based automated and consistent system for cartilage and meniscus segmentation and lesion detection on heterogeneous knee MR images collected from clinical routine practice.

PI_NAMEs: YANG, MINGRUI  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Acceleration;Age;articular cartilage;biomarker identification;Biomedical Engineering;biomedical imaging;Body mass index;career development;Cartilage;Cartilage Diseases;Clinic;Clinical;Clinical Management;Clinical Research;Clinical Treatment;cohort;computer science;Consultations;Consumption;cost;Data Set;deep learning;deep learning model;Degenerative polyarthritis;demographics;Detection;detection platform;Development;Development Plans;Diagnosis;Disease;Doctor of Philosophy;Environment;Evaluation;Faculty;Female;Gender;General Population;Goals;Healthcare Systems;Human;human old age (65+);Image;improved;Interdisciplinary Study;Knee;Knee Osteoarthritis;Knowledge;Lesion;Machine Learning;Magnetic Resonance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Mathematics;Measurement;Medical Care Costs;Medical Imaging;member;meniscal tear;Meniscus structure of joint;Mentors;Methods;Modeling;Musculoskeletal;musculoskeletal imaging;novel;Obesity;operation;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Outcome;outcome prediction;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Phase;Physical therapy;Population;predict clinical outcome;predictive modeling;Procedures;programs;radiologist;randomized, clinical trials;Reporting;Research;Research Personnel;Risk;Risk Factors;Role;routine practice;Scanning;Science;Scientist;statistics;System;Techniques;Time;Tissues;tool;Training;transfer learning;United States;Unnecessary Surgery;Work

PROJECT_TITLE: Automated Arthroscopic Partial Meniscectomy Patient Outcome Prediction using Deep Learning

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PI_NAMEs: COBB, MELANIE H. (contact)

PROJECT_TERMS: Abnormal Cell;Acceleration;Basic Science;Bioenergetics;Biological Markers;Cancer Center Support Grant;cancer initiation;cancer prevention;cancer therapy;Catchment Area;cell behavior;Cell Death Signaling Process;Cells;Cellular biology;Clinic;Clinical;Clinical Oncology;Collaborations;collaborative environment;Complement;Comprehensive Cancer Center;Data;design;Development;diagnostic technologies;Disease;Disease Progression;DNA Sequence Alteration;Doctor of Philosophy;Environment;epigenetic regulation;Evolution;Faculty;Fostering;fundamental research;Funding;Gene Expression Regulation;Genetic;Goals;Growth;Guidelines;Homeostasis;Human;Immunobiology;Infrastructure;insight;inter-institutional;Intervention;Intervention Studies;Journals;Knowledge;live cell imaging;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Medical;Medical center;member;Mentors;Metabolism;Molecular;mortality;Neoplasm Metastasis;neoplastic cell;Non-Malignant;novel strategies;Patients;Peer Review;Physicians;Physiology;Population;Population Research;Positioning Attribute;prevent;Prevention strategy;Primary Neoplasm;Process;Productivity;programs;Publications;Renal Carcinoma;Research;Research Personnel;Resistance;Resource Sharing;Role;Science;Scientist;Signal Transduction;Solid;Specimen;Structure;success;technology intervention;Therapeutic Intervention;Tissues;Translating;translational potential;Translations;treatment strategy;tumor;Tumor Cell Biology;tumor microenvironment;tumor progression;tumorigenesis;Vision;Work

PROJECT_TITLE: Cellular Networks in Cancer Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The comorbidity between substance abuse and mood disorders is an ongoing challenge for the mental health field, with a need for improved understanding of the mechanisms underlying these comorbid illnesses. The goal of this project is to identify the role of L-type calcium channels (LTCC) in mediating mood disorder phenotypes after repeated cocaine or repeated stress exposure. This work in rodent models will address a significant gap in current scientific understanding, will identify mechanisms by which LTCC blockade produces antidepressant and anxiolytic effects, and will provide a strong foundation for future clinical and therapeutic focused investigations.

PI_NAMEs: ADDY, NII A (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Abstinence;Address;Anti-Anxiety Agents;anti-depressive agents;antidepressant effect;Anxiety;Anxiety Disorders;associated symptom;Attenuated;Behavior;Behavioral;behavioral pharmacology;behavioral response;Bipolar Disorder;Brain;Calcium Channel Blockers;Chronic;Chronic stress;Clinical;Clinical Trials;Cocaine;Cocaine Dependence;cocaine exposure;cocaine seeking;cocaine self-administration;comorbidity;Cues;Data;Disease;disorder risk;Dopamine;drug abstinence;drug of abuse;drug seeking behavior;Electrochemistry;Exposure to;Female;Foundations;Future;gain of function mutation;Genes;Goals;High Prevalence;Human;improved;in vivo;Individual;inhibitor;Intravenous;Investigation;Isradipine;Knowledge;L-Type Calcium Channels;Laboratories;Major Depressive Disorder;male;Mediating;Mental Depression;Mental Health;mesolimbic system;Mood Disorders;Moods;mouse model;neurobiological mechanism;neuropsychiatric disorder;novel;novel therapeutic intervention;Nucleus Accumbens;Pathway interactions;Periodicity;Pharmaceutical Preparations;Phenotype;Pilot Projects;pre-clinical;Rattus;Regulation;Research;Rewards;risk variant;Rodent;Rodent Model;Role;Scanning;Self Administration;Signal Transduction;social;social deficits;Social Interaction;Stress;Substance abuse problem;substance use;Substance Use Disorder;Sucrose;Symptoms;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;tool;Ventral Tegmental Area;Work

PROJECT_TITLE: L-Type Calcium Channel Mechanisms Mediating Comorbid Substance Use and Mood Disorders


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: Project Narrative A functioning retina is the result of an extraordinary orchestration of complex pathways responsible for its development and homeostasis; any deficits in these pathways may lead to disease and loss of sight. We have recently shown that a powerful and unbiased state-of-the-science forward genetics approach can be used to identify novel gene-phenotype associations that are crucial to retinal health, and we propose now to exploit this strategy to identify and characterize genes and pathways that regulate: 1) retinal development and homeostasis, 2) retinal immune surveillance, and 3) early diabetic retinopathy. Our long-term goal is to leverage our research results for the discovery of novel therapeutic targets for retinal diseases and in the development of new retinal regeneration strategies.

PI_NAMEs: UFRET-VINCENTY, RAFAEL  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Anatomy;Blindness;causal variant;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Collaborations;Complex;Conceptions;CRISPR/Cas technology;Defect;Development;Diabetes Mellitus;Diabetic Retinopathy;Disease;Eligibility Determination;Ensure;Ethylnitrosourea;experimental study;exposure pathway;forward genetics;Functional disorder;Funding;Fundus;gene discovery;gene editing technology;Generations;Genes;Genetic;genetic approach;genetic pedigree;genetic predictors;Genome;Genotype;Goals;Health;Homeostasis;Immune;Immunologic Surveillance;immunoregulation;improved;Inflammatory;Injections;Injury;insight;interest;Investigation;Knowledge;Lead;Light;Literature;Maintenance;Maps;Mass Spectrum Analysis;Measurement;Mediating;Meiosis;Microglia;Modeling;Molecular;mouse genome;Mus;Mutagenesis;mutant;Mutate;Mutation;Natural regeneration;Nature;Neuroglia;Neurons;new therapeutic target;Nitrosourea Compounds;novel;novel therapeutic intervention;novel therapeutics;Optical Coherence Tomography;outer plexiform layer;Pathway interactions;Phenotype;Photoreceptors;Physiology;Predisposition;Process;Proteins;Proteomics;Protocols documentation;Publishing;Recovery;Reporting;Research;Retina;Retinal Defect;Retinal Diseases;retinal imaging;retinal regeneration;ribbon synapse;Role;Science;screening;single-cell RNA sequencing;Spottings;Streptozocin;success;System;Techniques;Testing;Thick;Thinness;trafficking;Vision

PROJECT_TITLE: Exploring Mechanisms in Retinal Development/Homeostasis, Retinal Immune Surveillance and Diabetic Retinopathy Using Forward Genetics


NIH_SPENDING_CATS: Cancer

PI_NAMEs: SIEGWART, DANIEL JOHN (contact)

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Antineoplastic Agents;Binding;Biochemical;Biochemical Pathway;Biochemistry;Biological;Biology;biophysical techniques;Cancer Biology;Cancer Center;cancer prevention;cancer therapy;Catchment Area;Chemicals;Chemistry;Clinic;clinical application;Clinical Trials;Collaborations;Colorectal Cancer;Comprehensive Cancer Center;design;Development;Dissection;Doctor of Philosophy;Drug Design;drug discovery;early phase trial;Foundations;Funding;Future;Goals;Human;improved;insight;Journals;Lead;Leadership;Licensing;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Medical;Medical center;Medicine;member;Molecular;Molecular Biology;Molecular Target;NMR Spectroscopy;novel anticancer drug;novel therapeutics;Oncogenes;Outcome;Pathogenicity;Pathway interactions;Patients;Peer Review;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Phenotype;preclinical study;programs;protein function;Proteins;Province;Publications;Reagent;Regulatory Pathway;Renal Carcinoma;Research;Research Priority;Resolution;Role;Scientist;Signal Pathway;small molecule;Structural Biologist;structural biology;Structure;Structure-Activity Relationship;Synthesis Chemistry;synthetic lethal interaction;Techniques;tool;translational impact;translational pipeline;translational study;Translations;X-Ray Crystallography

PROJECT_TITLE: Chemistry and Cancer Program


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative  A delayed/missed response to falling in nursing facilities can result in adverse consequences and even fatalities. WARE-Care: mmWave based fall Assessment and pRevEntion system, is proposed as a complementary tool to existed motion detection sensors (such as wearables and cameras) to capture the fall events and evaluate fall risks for elders living alone especially during night. The system will be non-contact and non-obtrusive, adhere to privacy protections, operate at safe electromagnetic radiation levels and is small, easy and practical to deploy.

PI_NAMEs: CAO, SIYANG  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, KRISTIN HEDGEPATH

PROJECT_TERMS: 3-Dimensional;Adult;adverse outcome;Age;Aging;Agreement;Alzheimer's Disease;Arizona;arm;Behavior;Behavior monitoring;Calibration;Canes;care costs;Care given by nurses;care systems;Caring;Cessation of life;Charge;Clinical;Clinical Trials;Communities;Complement;computer center;cost;Data;Databases;deep learning;design;Detection;Development;Devices;Diagnostic Services;Discipline of Nursing;Disease;Elderly;Electromagnetic Energy;Environment;Evaluation;Event;exposed human population;Extremely High Frequency Radio Waves;Face;Fall prevention;fall risk;falls;fear of falling;follow-up;follower of religion Jewish;Forearm;frailty;Gait;Goals;Health;Height;Hour;Human;human old age (65+);improved;Injury;interest;irritation;kinematics;Laboratories;learning network;Lighting;long short term memory;Lower Extremity;Machine Learning;Maps;Measurement;Measures;Medical;meter;Methods;Modeling;Monitor;Motion;motion sensor;Movement;network architecture;Network-based;neural network;neural network architecture;novel;Nursing Homes;Nursing Staff;older adult;Older Population;pandemic disease;Participant;Persons;portability;Posture;Prevention;Privacy;privacy protection;Privatization;Probability;Quality of life;Radar;Radiation;Recovery;recruit;Reporting;Research;Residual state;response;Risk;Risk Assessment;Safety;Sample Size;Seizures;sensor;Services;sex;signal processing;skeletal movement;Skeleton;Sleep;smartphone application;software development;System;Techniques;Technology;telehealth;Testing;Thigh structure;Time;tool;Training;Universities;Unmarried person;Upper arm;Upper Extremity;user-friendly;Validation;Visual;walker;Walking;walking performance;wearable device;wearable sensor technology;Weight;wireless data transmission;Work

PROJECT_TITLE: WARE-Care: a novel RF-based system to assess and prevent falling

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative Age-related macular degeneration (AMD) affects 30% of individuals over the age of 65 years and is the leading cause of vision loss in the Western World. Though the fundamental abnormalities occurring in retinal pigment epithelial cells (RPE) are not known, several pathogenic pathways altered in AMD have been identified including inflammation, lipid dysregulation, RPE barrier dysfunction, apoptosis among others. The objective of this grant is to investigate the role of the transcription factor, the Nuclear Receptor Related-1 protein (NURR1 or NR4A2) in RPE cells and development of dry AMD. Upon completion of this project we will have characterized the role of NURR1 in the RPE and tested the therapeutic potential of targeting NURR1 in mouse models of AMD. This will be the first demonstration of this novel signaling pathway in the posterior pole.

PI_NAMEs: MALEK, GOLDIS  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Affect;Age;age related;Age related macular degeneration;aged;aging related;Agonist;Apoptosis;Atrophic;Attenuated;Biochemical;Biological Process;Biology;Blindness;Blood-Retinal Barrier;Bruch's basal membrane structure;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cells;Central Nervous System;Characteristics;Complex;cytokine;Data;Deposition;design;Development;Disease;Drug Metabolic Detoxication;Drusen;efficacy evaluation;Elderly;Epidemiology;Epithelial Cells;epithelial injury;epithelial to mesenchymal transition;Epithelium;Etiology;Exposure to;extracellular;Eye;forkhead protein;FOXM1 gene;Functional disorder;gain of function;Genetic;Goals;Grant;Health;Homeostasis;Human;human old age (65+);Impairment;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;Inflammation;Inflammatory;Knowledge;Ligands;Link;lipid metabolism;Lipids;loss of function;Macrophage;Mesenchymal;Metabolism;Microglia;Molecular;Monitor;Morphology;mouse model;neuroprotection;Nonexudative age-related macular degeneration;novel;NR4A1 gene;NR4A2 gene;Nuclear Orphan Receptor;Nuclear Receptors;Oral Administration;Oxidants;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;Phenotype;photoreceptor degeneration;Pigment Epithelium;Play;prevent;Process;protein activation;protein expression;Proteins;Reactive Oxygen Species;response;Retina;Role;Severities;Signal Pathway;stressor;Structure of retinal pigment epithelium;System;Systemic disease;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Therapeutic Use Study;Tissue Donors;Tissues;Toxic effect;transcription factor;transdifferentiation;Vision;Western World;Wild Type Mouse

PROJECT_TITLE: Nuclear receptor driven mechanisms in aging and AMD


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ATHENS

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Millions of people are infected with Toxoplasma gondii and we need to understand how it causes disease. We discovered that polyphosphate (PolyP) synthesis is essential for the parasite survival. Our hypothesis is that polyPs interact with key proteins that are essential for the pathogenesis of Toxoplasma.

PI_NAMEs: MORENO, SILVIA N (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: acute infection;Address;AIDS-Related Opportunistic Infections;Alkalinization;Bacteria;Binding;Bioinformatics;biological adaptation to stress;Calcium;Catalogs;Catalytic Domain;Cells;Cellular Metabolic Process;Cellular Stress;chronic infection;Client;cohort;Complex;Cryptosporidiosis;Cryptosporidium;Cyst;Cytolysis;Cytosol;Data;Diatoms;Disease;Electrostatics;Energy-Generating Resources;Enzymes;Eukaryota;Experimental Designs;forgetting;fungus;Future;Gene Expression;Genome;Heat Stress;Homologous Gene;Human;human disease;Immune response;Immunocompromised Host;Infection;inorganic phosphate;Ions;knock-down;Knowledge;Link;Liquid substance;Lytic Phase;Malaria;Mammalian Cell;member;metal chelator;Modification;Molecular Chaperones;Morbidity - disease rate;mortality;mutant;Names;novel;Orthologous Gene;Parasites;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Phase;Plasmodium;Play;Polymers;Polyphosphates;Polyps;Population;Post-Translational Protein Processing;Process;Proteins;Proteome;Regulation;response;Role;Rupture;Saccharomyces cerevisiae;scaffold;Signal Transduction;System;Testing;Tissues;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;Vacuole;validation studies;Vertebrate Biology;Vertebrates;Virulence;Virulence Factors;Yeasts

PROJECT_TITLE: The role of polyphosphate in Toxoplasma gondii

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(02)]


PI_NAMEs: O'DONNELL, KATHRYN ANN (contact)

PROJECT_TERMS: Adult;animal imaging;Award;Biological Models;Cancer Biology;cancer cell;Cancer Cell Growth;Cancer Center;Cancer Center Support Grant;cancer initiation;Cancer Patient;Caring;Catchment Area;Cell Differentiation process;Cell division;cell growth;cell regeneration;cell stroma;Cell Survival;Cells;Chemistry;Clinic;Clinical;clinical application;clinical translation;Collaborations;Colorectal;Comprehensive Cancer Center;Cytoskeleton;Data;Development;Developmental Biology;Developmental Process;diagnostic biomarker;Doctor of Philosophy;Elements;Environment;Epigenetic Process;Extracellular Protein;Fostering;Functional disorder;Funding;Gene Expression;Genomics;Goals;Grant;Growth;Guidelines;high throughput screening;Homo;Human;Human Development;improved;improved outcome;Investigation;Investments;Journals;Kidney;Laboratories;Lead;lens;live cell imaging;Liver;Lung;Malignant Childhood Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;malignant phenotype;Medical center;member;Modeling;Molecular;multidisciplinary;NCI Center for Cancer Research;Neoplasm Metastasis;novel diagnostics;novel therapeutic intervention;Organ;organ growth;organ regeneration;Organism;Organogenesis;Pathogenesis;Pathway interactions;Patients;Peer Review;Physicians;Pilot Projects;pre-clinical;Process;Prognostic Marker;programs;Publications;Recurrence;Research;Research Personnel;Resource Sharing;Resources;Role;Scientist;Series;Signal Transduction;stem cell biology;stem cells;Tissues;tool;translational impact;translational potential;tumor;tumor progression;Work

PROJECT_TITLE: Development and Cancer Program


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative  The significant gaps in people who use opioids (PWUO)’s care seeking, testing, treatment, and retention are impeding efforts to address the current opioid epidemic. This study aims to mobilize community health workers and PWUO’s family members to support a continuum of addiction services in Vietnam. Study findings are expected to demonstrate a model of community-based addiction service continuum that can be transferable to other countries, including the U.S.

PI_NAMEs: LI, LI  (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: addiction;Address;Adherence;Attention;care seeking;Caring;Chronic;Collaborations;commune;Communicable Diseases;Communities;community based service;Community Developments;Community Health;Community Health Aides;Community Healthcare;comorbidity;Comprehension;Continuity of Patient Care;Country;Data;Decision Making;Drug usage;Epidemiology;Evidence based intervention;experience;Family;Family member;family support;Feedback;Geography;Health;health care availability;Health care facility;health service use;Health Services;Health Status;Healthcare;Hygiene;improved;Infrastructure;Intervention;Joints;Link;Long-Term Care;marginalization;medication-assisted treatment;meetings;member;Modeling;Monitor;National Institute of Drug Abuse;Nature;Neighborhood Health Center;Opiate Addiction;Opioid;opioid epidemic;opioid overdose;opioid use disorder;opioid user;Outcome;Outcome Measure;Participant;patient oriented;Phase;pilot test;Play;prevent;prevention service;Process;process evaluation;Provider;Randomized;Randomized, Controlled Trials;Research;Research Activity;Research Personnel;Role;Series;service delivery;Service delivery model;service gap;Service provision;service utilization;Services;social stigma;Source;Specialist;substance use;Support System;targeted treatment;Testing;therapy development;Time;Treatment Efficacy;Treatment outcome;treatment program;treatment services;Trust;United States Public Health Service;Vietnam;Work

PROJECT_TITLE: Strengthening Addiction Care Continuum through Community Consortium in Vietnam

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Down Syndrome;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Pediatric;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE Developmental disabilities (DD) present a major public health concern, especially in sub-Saharan Africa (SSA), where resources to diagnose and remediate them are severely limited. This proposal is aimed at establishing a large sample of children with DD in Zambia, providing a detailed characterization of the relevant phenotypes, studying the etiology of these diseases, documenting how they are regarded and treated within the community, to generate relevant recommendations for policy makers.

PI_NAMEs: GRIGORENKO, ELENA L (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: 14 year old;Address;Adolescent;Adopted;Africa;Africa South of the Sahara;African;aged;Area;Asia;Attitude;Behavior;Belief;Biological;Blindness;Botswana;Brain;burden of illness;Caregivers;Caring;Catchment Area;Characteristics;Child;Child Health;child services;childhood epilepsy;Church;Classification;Clinical;Communities;Community Services;Country;Data;Data Set;Dedications;Detection;Development;Developmental Disabilities;developmental disease;Diagnosis;Diagnostic;Differential Diagnosis;disability;Disease;dynamic system;early childhood;EEF1A2 gene;Electroencephalography;Ensure;Etiology;Event;Family;Fathers;Focus Groups;functional near infrared spectroscopy;Funding;Genetic Markers;Genome;Ghana;girls;Goals;Health;Health education;health record;Health Services;hearing impairment;Home;Hospital Administration;Hospitals;Household;human subject;improved;Income;Individual;Individuality;Individuals with physical disabilities;informant;Intellectual functioning disability;Interview;Kenya;Link;Literature;low and middle-income countries;Malawi;member;Mission;Monitor;Mothers;Namibia;neurophysiology;Nigerian;Pacifiers;Pathway Analysis;Pathway interactions;Perception;Personal Satisfaction;Persons;Phenotype;Policy Maker;policy recommendation;Population;Prevalence;proband;Province;Public Health;Punishment;Radial;recruit;remediation;Research;Research Personnel;Resources;Rural;Rural Community;rural setting;Sampling;Schools;Services;Siblings;Social Environment;social stigma;Source;Structure;Surveys;Sustainable Development;Tanzania;Trust;Typology;United Nations;United States National Institutes of Health;Universities;Witchcraft;Work;Youth;Zambia;Zimbabwe

PROJECT_TITLE: Transdiagnostic Associations Across Developmental Disorders

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE  Over 30% of pregnant American women are obese, which negatively affects fetal development with long-term consequences for offspring health. We found that maternal obesity leads to fibrotic and fatty infiltration (FFI) in offspring skeletal muscle and brown adipose tissue, which impair their metabolic function, and propose that maternal obesity enhances embryonic fibrogenesis to increase FFI in offspring. Knowledge obtained from proposed studies will provide molecular targets for therapeutics to improve embryonic development and subsequent metabolic health of offspring born to obese mothers.

PI_NAMEs: DU, MIN  (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 5'-AMP-activated protein kinase;Accounting;Adipocytes;Adipose tissue;Adult;Affect;American;Attenuated;Automobile Driving;Award;Body Weight;bone;Bone Morphogenetic Proteins;Brown Fat;Cell Lineage;Cells;Child;Coupled;Data;dermatome;Dermomyotome;Development;Diet;early onset;Elderly;Embryo;embryo tissue;Embryoid bodies;Embryonic Development;Enhancers;fatty acid oxidation;fetal;Fetal Development;Fetal Skeleton;Fetal Tissues;Fibroblasts;fibrogenesis;Genes;Glucose;Health;Homeobox;Impairment;improved;Infiltration;Insulin Resistance;Knock-out;Knowledge;Link;maternal obesity;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Metformin;molecular targeted therapies;mouse model;Muscle Fibers;myogenesis;Non-Insulin-Dependent Diabetes Mellitus;Obese Mice;obese mothers;obese person;Obesity;offspring;offspring obesity;Overweight;Pharmaceutical Preparations;Polycystic Ovary Syndrome;Predisposition;Pregnancy;pregnant;prenatal;progenitor;programs;promoter;Role;Sclerotome;Signal Transduction;Signaling Protein;single nucleus RNA-sequencing;single-cell RNA sequencing;Skeletal Muscle;skeletal tissue;Somites;somitogenesis;Source;stem cell biomarkers;stem cells;Structure;Testing;therapeutic development;Thinness;Tissues;Transcription Initiation Site;Woman

PROJECT_TITLE: Maternal obesity, AMPK and Developmental Programming

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Immunotherapy;Nanotechnology;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

PI_NAMEs: HAMMERS, HANS  (contact)

PROJECT_TERMS: Acidosis;Address;Adult;antagonist;Antitumor Response;Area;Autoantibodies;Award;Back;Basic Science;Biological Markers;biomarker discovery;Biotechnology;Breast;cancer cell;cancer diagnosis;cancer immunotherapy;cancer therapy;cancer type;Catchment Area;Cell Cycle Checkpoint;Cells;Chemical Modifier;Chemicals;Clinic;Clinical;clinical development;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Design;clinically relevant;Collaborations;combat;Communities;Community Outreach;Comprehensive Cancer Center;Correlative Study;design;Development;Diagnostic;Disease;DNA Repair;Drug Delivery Systems;drug development;early phase clinical trial;Education;Epigenetic Process;Equity;Estrogen Receptors;Excision;Faculty;Feedback;functional genomics;Funding;Future;Genomics;Goals;Hematologic Neoplasms;Human;humanized mouse;Image;imaging agent;imaging capabilities;Immune;Immune checkpoint inhibitor;Immune response;immunogenic;Immunologic Markers;Immunologic Surveillance;Immunooncology;Immunotherapy;improved;Infrastructure;inhibitor;innate immune pathways;Investigational Therapies;investigator-initiated trial;Investments;KRAS2 gene;Laboratories;Lead;Leadership;Libraries;Lung;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medical center;member;Metabolic;Metabolism;Molecular;molecular drug target;molecular marker;Monitor;mutant;nanoparticle;Nanotechnology;Natural Immunity;Natural Products;NCI Center for Cancer Research;Neoplasm Metastasis;neuro-oncology;new therapeutic target;novel;novel imaging technology;novel strategies;Oncology;Operative Surgical Procedures;Organ;Organoids;Pathologic;Phase;Population Sciences;Positron-Emission Tomography;Pre-Clinical Model;precision oncology;preclinical development;predicting response;Prediction of Response to Therapy;predictive marker;Program Sustainability;programs;Radiation Oncology;Radiation therapy;Radiation-Sensitizing Agents;recruit;Renal Carcinoma;Research;Research Personnel;response;Role;Science;siRNA delivery;Specimen;spheroids;success;synergism;targeted cancer therapy;Testing;Therapeutic;therapeutic biomarker;therapeutic development;therapeutic evaluation;therapy outcome;therapy resistant;Tracer;Translating;translational impact;Translational Research;translational research program;translational scientist;translational study;translational therapeutics;tumor;Tumor Antigens;tumor microenvironment;tumor progression;Work

PROJECT_TITLE: Experimental Therapeutics Program


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Nutrition

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: The discipline of nutrition touches on individuals of all nationalities and backgrounds, and indeed the most serious sequela of malnutrition are observed in the poorest and most under-represented sectors of society. In recognition of this fact, the IHN and this Training Program have long believed it was our responsibility not only to advance understanding of the underlying causes and consequences of malnutrition, both under-nutrition and increasingly, over-nutrition, but also to provide training to individuals from the communities most affected by the adverse health effects of poor nutrition. In this light, the IHN has for over 25 years maintained a vigorous PhD Training Program in nutritional sciences, renewal of support for which is sought in this application.

PI_NAMEs: FERRANTE, ANTHONY W (contact);ZELTSER, LORI M

PROGRAM_OFFICER_NAME: KAMARA, FANTA

PROJECT_TERMS: nutrition;Training

PROJECT_TITLE: Graduate Training in Nutrition


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infectious Diseases

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: NARRATIVE Intestinal parasites, including soil-transmitted helminths (STH), infect over 1.5 billion people worldwide, resulting in a massive global burden of disease. Mass drug administration (MDA) to at-risk populations is the cornerstone of the global strategy for controlling morbidity associated with STH infections; however, varied MDA program success indicates that re-infection from environmental reservoirs is common. This proposal leverages a novel, sensitive and specific molecular assay to detect STH DNA in large volumes of soil within a multi-country community- wide MDA randomized controlled trial to define, for the first time, the impact of an MDA intervention on soil reservoirs of STH, and to evaluate the potential for using soil STH DNA as a non-invasive surveillance tool to monitor human infection prevalence.

PI_NAMEs: AJJAMPUR, SITARA SWARNA RAO;IBIKOUNLÉ, MOUDACHIROU ;PICKERING, AMY J. (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Adherence;Affect;Area;Biological Assay;burden of illness;Collection;Communities;cost;cost comparison;cost effective;Country;COVID-19 pandemic;Data;Detection;detection method;Diagnostic;DNA;Effectiveness;egg;enteric pathogen;Epidemiology;Evaluation;Feces;field study;Foundations;Geography;helminth infection;Helminths;Home;Household;Human;Human Activities;improved;India;Individual;Infection;infection rate;infection risk;Infrastructure;Intervention;Intestinal parasite;Intestines;Laboratory Study;Location;Measurement;Methods;Modeling;Molecular;Molecular Analysis;Monitor;Morbidity - disease rate;novel;Only Child;Parents;Persons;Pharmaceutical Preparations;Population;Population Density;Populations at Risk;predictive modeling;Prevalence;prevent;Program Effectiveness;programs;Randomized, Controlled Trials;Recrudescences;Resources;Sampling;Sanitation;School-Age Population;Schools;Seasons;Site;Soil;soil sampling;Source;standard of care;stool sample;Study models;success;Surveillance Methods;Temperature;Testing;Time;tool;transmission process;Water;Water Supply

PROJECT_TITLE: Soil epidemiology: a new tool for environmental surveillance of soil-transmitted helminth infections in endemic settings.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative This research focuses on how to block the inflammation that strongly impacts the death of neurons, which leads to vision loss in many retinal diseases. We show that inhibition of macrophage migration inhibitory factor (MIF) prevents neuronal death in excitotoxic damage models relevant to ischemia, including vein/ artery occlusion, sickle cell retinopathy, retinopathy of prematurity, and diabetes. This research will define the important functional relationships between MIF, signaling pathways, glia-mediated neuronal survival, and genome-wide transcriptional switches during retinal damage to set the stage for future studies targeting key molecular pathways to prevent and recover visual loss from retinal damage.

PI_NAMEs: CEBULLA, COLLEEN MARIE (contact)

PROJECT_TERMS: Affect;antagonist;Apoptosis;artery occlusion;Astrocytes;Bioinformatics;Blindness;Blood flow;Blood-Retinal Barrier;Cell Death;Cells;Chick;Clinical;clinically relevant;Complement Factor D;conditional knockout;Confocal Microscopy;cytokine;Data;Databases;Diabetes Mellitus;Diabetic Retinopathy;Disease;Dopachrome isomerase;druggable target;Epiretinal Membrane;excitotoxicity;Eye;Future;Gene Deletion;Gene Expression;Genetic;genetic approach;genetic association;Genetic Polymorphism;Genetic Transcription;genome-wide;Glial Growth Factor;Gliosis;Goals;Health;IL6ST gene;improved;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;Ischemia;Knowledge;Libraries;LoxP-flanked allele;Macrophage;Mediating;Mediator;Metabolic;Microglia;MIF gene;migration;Migration Inhibitory Factor;Modeling;Molecular;mouse model;Muller's cell;Mus;N-Methylaspartate;Neuroglia;neuron loss;neuronal survival;Neurons;Out-Migrations;Oxidative Stress;Pathogenicity;Pathologic;Pathway interactions;Patient-Focused Outcomes;pharmacologic;Photoreceptors;Play;prevent;promoter;Proteomics;Reperfusion Therapy;Research;research clinical testing;Resolution;Retina;retinal damage;Retinal Detachment;Retinal Diseases;retinal ischemia;retinal neuron;Retinopathy of Prematurity;Role;sickle cell retinopathy;side effect;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Systemic disease;Testing;Therapeutic;transcriptome;Up-Regulation;Vascular Diseases;Veins;Vision

PROJECT_TITLE: Characterization of the role of MIF on retinal health and disease

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Comparative Effectiveness Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Liver Cancer;Liver Disease;Prevention;Primary Health Care;Rare Diseases;Social Determinants of Health

PI_NAMEs: COWELL, LINDSAY G. (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;Area;base;Biological Markers;biomarker validation;Biometry;cancer biomarkers;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;cancer diagnosis;cancer health disparity;cancer prevention;cancer risk;care delivery;Caring;Catchment Area;clinical practice;Clinical Trials;Collaborations;colon cancer screening;Colon Carcinoma;Colonoscopy;Colorectal Cancer;Communities;comparative effectiveness;comparative effectiveness trial;Comprehensive Cancer Center;Country;County;Data;Data Collection;Data Science;Decision Making;design;Diagnosis;Discipline;Discipline of Nursing;Disease;Doctor of Philosophy;Early Diagnosis;Effectiveness;Effectiveness of Interventions;Eligibility Determination;Epidemiology;evidence base;experience;Faculty;Funding;Goals;Guidelines;HCV screening;Health;health care settings;Health Services;Health Services Research;Health system;Healthcare Systems;Hepatitis C;Hospitals;Human Papilloma Virus Vaccination;improved;Individual;Infrastructure;inter-institutional;Interdisciplinary Study;Intervention;Intervention Studies;Investments;liver cancer prevention;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Medical;Medical center;member;minority patient;mobile application;multidisciplinary;Outcome;outreach;patient oriented;patient population;patient portal;Patients;Peer Review;Persons;Population Research;Population Sciences;Portal System;Practice Guidelines;pragmatic trial;Prevention;prevention practice;Primary carcinoma of the liver cells;primary care clinic;Process;programs;Provider;Public Health Schools;Publications;Race;Randomized, Controlled Trials;recruit;Research;Research Personnel;safety net;Science;screening;Screening for cancer;Screening for Hepatocellular Cancer;Services;Site;Social Psychology;survivorship;System;Telephone;Testing;Texas;tobacco control;Training;Translating;translational impact;treatment as usual;trend;Triage;trial design;U-Series Cooperative Agreements;Underserved Population;Vulnerable Populations;Work

PROJECT_TITLE: Population Science and Cancer Control Program


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: COLLEGE STATION

ORG_DEPT: PHYSIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Project Narrative Diabetes mellitus causes progressive functional and structural damage of blood vessels and neurons in the retina of the eye that can lead to vision loss, and is the leading cause of blindness among working-aged adults in the United States. Our studies demonstrate that early diabetes can cause abnormal regulation of the retinal microvessels (arterioles and venules) leading to insufficient supply of oxygen and nutrients to the neural cells for proper function. Because effective therapies are lacking to treat vascular and neural damage during the advanced stage of diabetes, the goal of this proposal is to identify novel destructive proteins in the retinal microvasculature that can be targeted for therapy to improve blood flow and consequently the retinal function in early diabetes before the development of irreversible structural damage to the retina.

PI_NAMEs: HEIN, TRAVIS W (contact);KUO, LIH

PROJECT_TERMS: Address;Adult;Age;aged;Animal Model;Animals;arteriole;Blindness;blood damage;Blood flow;Blood Flow Velocity;Blood Vessels;Clinical;Complications of Diabetes Mellitus;constriction;Data;Development;Diabetes Mellitus;diabetic;Diabetic Angiopathies;Diabetic Retinopathy;differential expression;Disease;effective therapy;Electroretinography;Endothelin-1;Endothelin-converting enzyme 1;Endothelium;Event;experience;extracellular;Eye;Eye diseases;Family suidae;Functional disorder;Goals;Health;Human;improved;Inflammatory;innovation;insight;Insulin-Dependent Diabetes Mellitus;Ischemia;knock-down;Knowledge;Link;MAPK8 gene;Microcirculation;Microvascular Dysfunction;Modeling;Molecular;Molecular Target;Morphology;N-terminal;neural;Neural Retina;Neurons;novel;Nutrient;Ocular Physiology;Outcome;Oxygen;p38 Mitogen Activated Protein Kinase;Pathology;Pathway interactions;Perfusion;Phosphotransferases;Physiological;preservation;Production;Proteins;Regulation;Research;response;Retina;retinal damage;Retinal Diseases;retinal ischemia;Rho-associated kinase;ROCK1 gene;Role;sight restoration;Signal Pathway;Signal Transduction;Signaling Molecule;Streptozocin;stress kinase;Structure;System;targeted treatment;Testing;Time;treatment strategy;type I diabetic;United States;vasoconstriction;Vasoconstrictor Agents;Vasomotor;venule;Vision

PROJECT_TITLE: Endothelin-1 System Activation and Retinal Microvascular Dysregulation during Early Diabetes

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative  Small changes in acoustic features of communication sounds can dramatically alter their meaning; for example, in human language, the words “bat” and “rat,” sound similar, yet they refer to two different animals. Furthermore, behavioral context aids sound discrimination, yet the neuronal pathways that mediate the effect of context on the discrimination of complex sounds with different semantic information remain difficult to study in human subjects, creating the crucial need for mammalian animal models that are auditory specialists. The proposed research, employing bats as model organisms, will investigate the mechanisms mediating auditory processing in the mammalian brain, and will contribute to knowledge that can help in the diagnosis and treatment of humans who suffer from communication disorders.

PI_NAMEs: SALLES, ANGELES  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TITLE: Neural processing of communication sounds: acoustic features and semantic content

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative To return a 130 mph serve, a tennis player needs to prepare to strike the ball early, before it is actually in motion, and analyze the ball's trajectory very rapidly (within 400 milliseconds approximately). We propose a series of experiments to investigate how motor preparation and perceptual processing interact and determine the per- formance of a subject during an urgent decision-making task, and how the activity of nerve cells in the cerebral cortex contributes to these two crucial functions, i.e., analyzing visual stimuli and generating motor actions in response to them. The results will help us characterize the mechanisms that the brain uses to make choices, and this, in turn, will help us understand anomalous behaviors in which those mechanisms malfunction, such as risky decision making, proneness to distraction, and emphasis on instant gratiﬁcation over long-term gains.

PI_NAMEs: SALINAS, EMILIO  (contact);STANFORD, TERRENCE R

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TITLE: CRCNS: investigating perceptual processing speed and its impact on choice behavior


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Mental Health;Nutrition;Obesity;Prevention

PHR: NARRATIVE Understanding what drives eating of highly palatable foods can help us understand why people develop obesity. In this project we will assess the impact of a medication that helps people lose weight while people are exposed to situations which they find stressful or in which they are exposed to highly craved foods. The study will help us to understand what processes may help in lowering craving and eating of highly craved foods to impact weight outcomes.

PI_NAMEs: JASTREBOFF, ANIA  (contact);SINHA, RAJITA

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Address;Affect;American;analog;Attenuated;Automobile Driving;Biochemical;biological adaptation to stress;Biology;Bite;Body mass index;Body Weight decreased;Brain;Calories;cancer type;Cardiovascular Diseases;Chronic stress;cost effective;craving;Cues;Data;Diet;Double-Blind Method;Eating;Eating Disorders;Environment;Exposure to;Food;food craving;Funding;Gender;ghrelin;glucagon-like peptide 1;Glucocorticoids;Guided imagery;Human;Hunger;Hydrocortisone;Hyperphagia;improved;indexing;Individual;Individual Differences;innovation;Insulin Resistance;insulin sensitivity;Intake;Investigational Therapies;Laboratories;laboratory experiment;Measures;men;Metabolic;Metabolism;Modeling;Motivation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;Obesity associated disease;Obesity Epidemic;obesity risk;OGTT;Outcome;outcome prediction;Outpatients;Participant;Pathway interactions;Persons;Pharmaceutical Preparations;Phase;Physical activity;Placebo Control;Placebos;Process;Progress Reports;prospective;Randomized;Relaxation;response;Rewards;Stress;Testing;Therapeutic Studies;Touch sensation;transmission process;treatment duration;treatment effect;United States;Weight;Weight Gain;Woman;Work

PROJECT_TITLE: GLP-1 analogue effects on food cues, stress, motivation for highly palatable foods, and weight

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: PRUITT, SANDI LEIGH (contact)

PROJECT_TERMS: Address;Adult;anti-cancer research;Area;Asian;Behavior;Behavioral Risk Factor Surveillance System;Biological Factors;Black race;Cancer Burden;cancer care;Cancer Control;cancer education;Cancer Etiology;cancer health disparity;cancer prevention;cancer type;Caregivers;Catchment Area;Censuses;Childhood;Clinical Trials;Colorectal Cancer;Communication;Communities;community advisory board;community engaged research;community engagement;Community Healthcare;community organizations;Community Outreach;community partnership;Comprehensive Cancer Center;Counseling;County;Data;Data Sources;data visualization;design;Diagnostic;Diagnostic Services;Disparity;Dissemination and Implementation;Doctor of Philosophy;Educational workshop;Ensure;Environmental Risk Factor;Equity;Ethnic Origin;Evaluation;Event;evidence base;Family;Fostering;Funding;Geographic Locations;Goals;Grant;Guidelines;Health;health care availability;health care settings;Health Personnel;Health Resources;Healthcare;Healthcare Systems;Hepatitis C;Heterogeneity;High Prevalence;Hispanic;Hospitals;Human Papilloma Virus Vaccination;implementation design;Improve Access;improved;Incidence;Individual;Infrastructure;innovation;Insurance;Interdisciplinary Study;Intervention;Investments;Leadership;Lung;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Media;Medicaid;Medical center;member;metropolitan;Minority;Minority Groups;Mission;Modeling;Monitor;NCI Center for Cancer Research;neoplasm registry;Not Hispanic or Latino;novel;Outcome;outreach;outreach program;patient navigation;Patients;Policies;Population;Prevention;Primary carcinoma of the liver cells;Process;programs;Provider;Psychosocial Factor;Public Health;Race;recruit;Renal Carcinoma;Research;Research Institute;Research Personnel;Research Priority;Rural;safety net;Scientist;screening;Screening for cancer;screening program;screening services;Series;Services;social media;Socioeconomic Status;Strategic Planning;survivorship;System;Technology;Texas;Tobacco;Tobacco Use Cessation;Training;Translational Research;tumor progression;Uninsured;Vision;Visualization software;Work

PROJECT_TITLE: Community Outreach, Engagement, and Equity


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative Gene expression is highly regulated by cells to allow for correct function and response to extrinsic signals. Despite protein synthesis being a fundamental process in gene expression, our understanding of the mechanisms of specialized mRNA translation remains limited. The proposed research will determine how translation initiation factors regulate cellular phenotypes, and has implications on rational design of therapeutics targeting gene dysregulation in human disease.

PI_NAMEs: LEE, AMY SI-YING (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Aging;Binding;Biochemical;Cell Differentiation process;cell growth;Cell Physiology;Cells;Complex;Congenital Disorders;Cues;Differentiation and Growth;Disease;Gene Expression;Gene Expression Regulation;Genes;Genetic Techniques;human disease;innovation;insight;Malignant Neoplasms;Mediating;Methodology;Methods;Molecular;mRNA Translation;novel;Peptide Initiation Factors;Phenotype;Process;programs;Protein Biosynthesis;Proteins;rational design;Regulation;Research;response;Ribosomal Proteins;Ribosomes;RNA Binding;Role;scaffold;segregation;Signal Transduction;System;therapeutic target;Transcript;Translational Regulation;Translations;Work

PROJECT_TITLE: Mechanisms of eIF3-mediated translation regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: LEE, JEON  (contact)

PROJECT_TERMS: anti-cancer research;Area;Award;Basic Science;Budgets;Cancer Center Support Grant;Charge;clinical investigation;Clinical Investigator;Clinical Sciences;Comprehensive Cancer Center;Development;Extramural Activities;Funding;Funding Mechanisms;Goals;Grant;innovation;investigator-initiated trial;Investments;Leadership;Link;Medical center;National Cancer Institute;National Clinical Trials Network;Pilot Projects;Population Sciences;Request for Applications;Research;Research Personnel;Research Project Grants;Research Support;Resources;Strategic Planning;Translational Research

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: ARTEAGA, CARLOS L (contact)

PROJECT_TERMS: Accountability;Achievement;anti-cancer research;Area;Award;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer health disparity;cancer prevention;Caring;Catchment Area;Charge;Clinical;clinical care;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Education;Education and Outreach;Evaluation;experience;Feedback;Foundations;Goals;implementation strategy;Intervention Trial;Investments;Leadership;Maps;Medical center;meetings;Mission;Modeling;National Cancer Institute;novel;Patient Care;Phase;Play;Policies;Practice Management;Process;Recording of previous events;recruit;Research;Research Personnel;Resource Allocation;Resources;Role;Science;Strategic Planning;success;Texas;Training and Education;Translating;Translational Research;translational scientist;Vision

PROJECT_TITLE: Leadership, Planning, and Evaluation


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Mental Health;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: PROJECT NARRATIVE Regular exercise and lifestyle physical activity (PA) is critical for quality of life and longevity, and particularly important for a healthy heart. We aim to test the efficacy of a new cognitive-behavioral intervention, called BE- FIT, for patients enrolled in outpatient cardiac rehabilitation that reduces exercise anxiety, a common barrier to physical activity.

PI_NAMEs: FARRIS, SAMANTHA GWEN (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Accelerometer;Acute;Adherence;Adult;Adverse event;Age;Age Years;age-related disease;Aging;aging population;aging related;Alzheimer's Disease;Anxiety;anxious;Awareness;Behavior;behavior change;Behavioral;Behavioral Mechanisms;Behavioral trial;Belief;Blood Pressure;bodily sensation;Cardiac;Cardiac rehabilitation;Cardiovascular Diseases;Cardiovascular system;Chest;Clinical;Cognition;Cognitive;cognitive process;Cognitive Therapy;Coronary heart disease;Data;deconditioning;Dementia;design;disability;Dizziness;efficacy testing;Electrocardiogram;Enrollment;Ensure;Equation;Esthesia;Event;Exercise;exercise intensity;exercise physiologist;exercise prescription;exercise rehabilitation;Exertion;experience;Exposure to;falls;Fatigue;Feedback;Female;fitbit;frailty;Fright;Future;Goals;Grant;Health;Health education;health related quality of life;Heart;Heart failure;heart function;Heart Rate;improved;Individual;Informal Social Control;Intervention;intervention effect;Knowledge;Life Style;Link;Longevity;Lung;Maintenance;Manuals;Measures;Mediating;Monitor;novel;Operative Surgical Procedures;Outcome;Outpatients;Pain;participant enrollment;patient population;Patients;Physical activity;Physical Exercise;Physiological;Physiological Processes;Pilot Projects;Population;preservation;Prevention;Procedures;programs;psychological distress;Psychologist;Public Health;Quality of life;Race;Randomized;Randomized, Controlled Trials;Research;Risk;Safety;Science;Shortness of Breath;Specific qualifier value;Strenuous Exercise;Stroke;Structure;Sweating;System;Testing;theories;Time;Treatment Efficacy;Uncertainty;United States National Institutes of Health;uptake;Work;Wrist

PROJECT_TITLE: A tailored exposure intervention targeting exercise anxiety and avoidance in cardiac rehabilitation

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE  Shigellosis or bacillary dysentery remains a serious global public health problem, especially for children under the age of five. The ability for Shigella species to cause dysentery requires a functional type III secretion apparatus or injectisome which delivers host-altering effector proteins into the cells of the large intestine. This research will explore the assembly and function of the cytoplasmic portions of the injectisome by identifying key protein-protein interfaces and protein structural shifts that contribute to injectisome assembly, stability and function. These findings will lay the foundation for future development of small molecule inhibitors that will help in the treatment of bacillary dysentery.

PI_NAMEs: LIU, JUN ;PICKING, WILLIAM D. (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Adaptor Signaling Protein;Age;Amino Acids;Architecture;Biochemical;biophysical analysis;biophysical techniques;Cell membrane;Cells;Child;Childhood;Cognitive;Communication;Complex;Cryo-electron tomography;Cytoplasm;Data;Development;Diarrhea;Dissection;Dysentery;Elements;Ensure;Event;flexibility;Foundations;Future;Image;imaging approach;imaging modality;Impairment;improved;In Situ;In Vitro;Incidence;insight;Investigation;kinetosome;Knowledge;Large Intestine;Learning;Membrane;Methods;Modeling;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;Movement;mutant;Mutation Analysis;nanomachine;Nature;Needles;new therapeutic target;pathogen;Positioning Attribute;Process;protein protein interaction;Proteins;Public Health;Research;Resolution;Shigella;Shigella Infections;small molecule inhibitor;Sorting;Structure;Structure-Activity Relationship;System;Tertiary Protein Structure;Testing;Type III Secretion System Pathway;Virulence;Virulence Factors;Visualization

PROJECT_TITLE: Characterization of assembly and activation of the Shigella type III secretion injectisome

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PI_NAMEs: RAHIMI, ASSAL SHOUSHTARI (contact)

PROJECT_TERMS: Adult;adverse event monitoring;Age;anti-cancer research;Attention;Awareness;Cancer Center Support Grant;cancer clinical trial;Catchment Area;Child;Childhood;Clinical Cancer Center;Clinical Data;Clinical Oncology;Clinical Protocols;Clinical Research;clinical trial participant;Clinical Trials;Combination immunotherapy;Community Outreach;Comprehensive Cancer Center;Conduct Clinical Trials;County;Data;data management;Dedications;demographics;Dependence;design;Diagnosis;Disease;Documentation;Electronics;Eligibility Determination;Enrollment;Ensure;Equity;ethnic diversity;ethnic minority;expectation;Faculty;Funding;Health;Healthcare Systems;Hospitals;improved;Individual;Infrastructure;inhibitor;Institution;Intervention;Intervention Trial;investigator-initiated trial;Leadership;Libraries;life span;Location;Malignant neoplasm of brain;Malignant neoplasm of lung;Malignant Neoplasms;Medical center;Metabolic;Minority;Minority Groups;Minority Participation;Monitor;Multicenter Trials;National Cancer Institute;older adult;oncology program;Operations Research;Pediatric Oncology;Pediatric Oncology Group;Persons;Physician Executives;Procedures;Process;process improvement;Protocol Compliance;Protocols documentation;Provider;Publishing;quality assurance;racial diversity;racial minority;Radiation therapy;Renal Carcinoma;Reporting;repository;Research;Research Activity;Research Personnel;research study;Risk;Safety;safety net;Satellite Centers;Services;Site;Solid Neoplasm;Support Groups;System;systems research;Technology;Texas;Time;timeline;Training;treatment trial;trial design;Underrepresented Minority;Underrepresented Populations;Underserved Population;Woman;Work

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE The development of a highly skilled diverse workforce that will impact all aspects of health related research efforts is essential to sustain the Nation’s research priorities, scientific and economic competitiveness. The UC San Diego Building a Respectful, Inclusive Culture Program will address this need by providing training modules that will catalyze changes in scientific, clinical and research training environments optimized for productive learning and research that are free from harassment, intimidation and discrimination. Creating a culture of respect, trust and safety in the academic environment is imperative for protecting trainees and learners, allowing them to learn and work in an environment conducive to the pursuit of excellence.

PI_NAMEs: REZNIK, VIVIAN ;TREJO, JOANN  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Biomedical Research;California;career development;Case/Control Studies;Climate;climate science;Clinical;clinical training;Community Health Education;design;Development;Discrimination;Diverse Workforce;Economics;education research;Educational Curriculum;effectiveness evaluation;Environment;Ethnic Origin;evidence base;Extramural Activities;Faculty;faculty mentor;Funding;General Population;Goals;Grant;harassment;Health;Health Sciences;health training;Healthcare;improved;Individual;innovation;Institution;instrument;K-Series Research Career Programs;Learning;Measurable;Measures;Mentors;National Institute of General Medical Sciences;Outcome;Participant;Pilot Projects;Productivity;Program Development;programs;psychologic;Publishing;Race;Randomized;Recording of previous events;recruit;Research;research and development;Research Design;Research Personnel;Research Priority;Research Training;Safety;skills;Students;Surveys;Testing;Training;Training Activity;Training Programs;Translational Research;Trust;United States National Institutes of Health;Universities;Woman;Work


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Hematology

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Many anti-thrombotic agents are in use for prophylaxis, but therapy of thrombi is limited to lysis by plasminogen activators such as urokinase. Yet, no drug is safe and effective in conditions associated with combined acute high risk of thrombosis and bleeding. Treatment of thromboses in these patients, e.g., in the early post-surgery period, is an unmet medical need. To achieve this challenging goal, we pioneered coupling of these drugs to carrier blood cells, red blood cells and platelets. Our previous studies affirmed that this strategy works in animal models of thrombosis without provoking bleeding. In the present project, we will transform these prototypes into novel molecular and cellular antithrombotic agents testable in humans, and will define their mechanisms and appraise their benefit/risk ratio in pre- clinical translational studies.

PI_NAMEs: MUZYKANTOV, VLADIMIR R (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Abnormal Red Blood Cell;activated Protein C;Acute;Address;Adhesions;Adhesiveness;Animal Model;Animals;Antiinflammatory Effect;Benign;Binding;Biodistribution;Biological Products;biomaterial compatibility;biomechanical test;Biomechanics;Blood;Blood Cells;Blood Platelets;Blood Vessels;Brain Injuries;Cells;Circulation;Clinic;Clinical;clinical application;Clinical Research;clinical translation;Coagulation Process;Complement Activation;Complex;Coupled;Coupling;COVID-19;Cytolysis;Data;design;Development;Disease;Dose;Drug Delivery Systems;Drug Kinetics;Embolism;Endothelium;Endotoxemia;Epitopes;Erythrocytes;Fibrinolysis;Fibrinolytic Agents;Glycoproteins;Goals;Hemorrhage;Hemostatic Agents;high risk;Hour;Human;Immobilization;Impairment;in vivo;in vivo Model;Inflammation;Inflammatory;Injections;insight;interest;Intravenous infusion procedures;invention;Kinetics;Lead;Leg;Life;Lung;Mediating;Mediator;Medical;Microfluidics;Modeling;Modification;Molecular;mouse model;Mus;mutant;novel;novel strategies;off-target site;Operative Surgical Procedures;Outcome;Pathologic;Patients;Perfusion;Phagocytes;Pharmaceutical Preparations;Physicians;Pilot Projects;Plasminogen Activator;Postoperative Period;pre-clinical;preservation;prevent;Primates;prophylactic;Prophylactic treatment;prototype;Regimen;Regional Perfusion;Regulation;Rhesus;Risk;risk/benefit ratio;Safety;Site;Source;Structure;Surgical Hemostasis;System;targeted agent;Testing;Therapeutic;Thrombin;thromboinflammation;Thrombomodulin;Thromboplastin;Thrombosis;thrombotic;Thrombus;Time;Transgenic Mice;Transgenic Organisms;translational study;Trauma;uptake;Urokinase;Vascular Diseases;Vascular Endothelium;Venous Thrombosis;Work

PROJECT_TITLE: BC-mediated delivery of thromboprophylaxis

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Pediatric

ORG_CITY: DAYTON

ORG_NAME: UNIVERSITY OF DAYTON

PHR: This proposal utilizes Drosophila (fruit fly) eye model to study the genetic mechanism of axial patterning (Dorso-ventral, DV patterning) and growth, a critical and a fundamental process required for the transition of a single layer of cells into a three-dimensional organ. Given the conservation of genetic machinery (genes) required for these fundamental processes, we propose to study the (i) molecular genetic function of DV patterning genes in patterning and growth (ii) and interactions of these DV genes with evolutionarily conserved growth regulatory Hippo signaling pathway with emphasis on discerning crosstalk between two core pathways that are known to act independently in regulating Wingless signaling and thereby determining positional fate and regulate growth during organogenesis. These studies will have significant bearing on understanding the genetic basis of organogenesis, cause of abnormal processes that lead to visual system birth defects, retinal defects, and therefore is of immediate relevance and importance to human health.

PI_NAMEs: KANGO-SINGH, MADHURI ;SINGH, AMIT  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: 3-Dimensional;Affect;antagonist;Biological Assay;Cell Lineage;Cells;Chromatin;Congenital Abnormality;Defect;Development;Differentiation and Growth;Dorsal;Drosophila eye;Drosophila genus;Drosophila melanogaster;early childhood;Epithelium;Etiology;Event;Eye;Eye Development;Family;fly;gene interaction;Generations;Genes;Genetic;Genetic Epistasis;Genetic study;Genetic Transcription;Goals;Growth;Head;Health;Homeodomain Proteins;Human;insight;Knowledge;loss of function;Malignant Neoplasms;member;Modeling;Molecular Genetics;monolayer;morphogens;Neoplasm Metastasis;Orbital separation excessive;Organ;Organism;Organogenesis;Orthologous Gene;paracrine;Pathway interactions;Pattern;Phenotype;Play;Primordium;Process;Protein Family;Proventriculus;Regulation;Regulator Genes;Retinal Defect;Retinal Diseases;Role;Signal Pathway;Signal Transduction;Signaling Protein;spatiotemporal;Specific qualifier value;Testing;transcription factor;Vertebrates;Vision;Visual Fields;Visual System

PROJECT_TITLE: Genetic Basis of Dorso-Ventral Patterning in the Drosophila Eye

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


PI_NAMEs: COURTNEY, KEVIN D (contact)

PROJECT_TERMS: Age;anti-cancer research;Area;authority;Cancer Center Support Grant;Child;Clinical Research;Clinical Sciences;Committee Membership;Comprehensive Cancer Center;Data;design;Discipline;Disease;Doctor of Philosophy;Education;Electronics;Ensure;Ethnic Origin;expedited review;Faculty;Frequencies;Gender;Health;Healthcare Systems;Hospitals;human subject;improved;Industry;Institution;Institutional Review Boards;Leadership;Malignant Neoplasms;Medical center;meetings;Modification;Monitor;Oncology;Outcome Study;Participant;Peer Review;Policies;Population Sciences;Population Study;Procedures;Process;Protocols documentation;Race;Recommendation;Reporting;Research;Research Personnel;Research Priority;research study;response;Review Committee;Role;Safety;sound;System;timeline

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: STANFORD UNIVERSITY

PHR: Public health narrative: Movement related injuries and disorders will affect the majority of the population at some point in their lifespan, and treatments are difficult to develop because we have limited ability to predict how a proposed treatment will change the neuromusculoskeletal dynamics of a patient. Machine learning approaches have the potential to predict, simulate, and analyze human movements under different scenarios. Using these ML-based models to predict patient responses to hypothetical treatments would radically shorten the development time for novel treatments, but today we lack sufficient clean public data to apply these methods. By developing a set of new tools to automatically process and aggregate movement data, we will create a dataset of massive size, radically simplify sharing new data, and lead to a sea change in analysis of movement and prediction of treatment outcomes.

PI_NAMEs: LIU, CHENG-YUN KAREN (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Address;Advertising;Affect;Agreement;Algorithms;Automation;Biomechanics;bone;cloud based;Cloud Service;collaborative approach;Communities;Community Outreach;Computer software;Computer Vision Systems;computerized data processing;Consumption;cost;Country;Data;Data Collection;data de-identification;Data Science;Data Set;data sharing;data standards;Databases;Decentralization;design;Development;Disease;Drops;Electromyography;Engineering;Foundations;Friction;Goals;Human;Image;improved;Incentives;individual patient;Injury;innovation;Institution;Label;large scale data;Letters;life span;Machine Learning;machine learning method;Manuals;Measurement;member;Methods;Modeling;Modernization;Molecular Biology;Motion;Movement;movement analysis;Musculoskeletal;neuromusculoskeletal;Newsletter;novel;open source;open source tool;Optics;patient response;Patient-Focused Outcomes;Patients;Persons;Population;Prediction of Response to Therapy;predictive tools;prevent;privacy preservation;Process;Property;prototype;Public Health;Quality of life;reconstruction;Research Personnel;Resources;Running;Sea;Secure;Self-Help Devices;sensor;Services;social;social media;Speed;success;Techniques;Time;tool;Treatment outcome;Universities;Vendor;Walking;Work

PROJECT_TITLE: AddBiomechanics: Automatic Processing and Sharing of Human Movement Data


PI_NAMEs: AHN, CHUL W (contact)

PROJECT_TERMS: anti-cancer research;Award;Basic Science;Biological Markers;Biometry;Biostatistics Shared Resource;Biotechnology;Cancer Center Support Grant;cancer clinical trial;Cancer Research Project;Clinical;Clinical Oncology;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Complex;Comprehensive Cancer Center;Computer Hardware;Computer software;Consultations;Data;Data Analyses;data management;data quality;Data Science;Databases;design;Development;Doctor of Philosophy;Education;Educational workshop;Electronic Health Record;Ensure;Epidemiology;experimental study;Extramural Activities;Faculty;Funding;Genetic;Goals;Grant;innovation;insight;Institution;International;Investigation;investigator-initiated trial;Journals;lectures;Malignant Neoplasms;Manuscripts;Medical center;member;method development;Methodology;Methods;Monitor;multidimensional data;Nature;NCI Center for Cancer Research;novel therapeutics;Oncology;Peer Review;Play;Population;population based;Population Sciences;Population Study;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Protocols documentation;Publications;Publishing;quality assurance;Quality Control;randomized trial;recruit;Reproducibility;Research;Research Design;Research Personnel;Resource Sharing;Resources;Role;Safety;Screening for cancer;Services;Statistical Methods;statistical service;success;Therapeutic Agents;Therapeutic procedure;tool;Training and Education;translational pipeline;Translational Research;trial design;Work;Writing

PROJECT_TITLE: Biostatistics Shared Resource


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Depression;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Women's Health Research

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PUBLIC HEALTH RELEVANCE MDD affects women nearly twice as often as men, but the neurobiological underpinnings of this discrepancy are unclear. We have made the exciting discovery that a specific circuit in the brain is more excitable in female mice than in males and will investigate the mechanisms by which testosterone regulates the excitability of this circuit to uncover novel downstream targets critical for stress resilience. This work is relevant to NIMH’s high priority interest in research utilizing sex as a biological variable and investigating mental health disparities, and we utilize innovative techniques to uncover basic pathophysiology that may be exploited as novel sex-specific therapeutic interventions in MDD.

PI_NAMEs: MAZEI-ROBISON, MICHELLE SUZANNE;ROBISON, ALFRED J (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Affect;Affinity Chromatography;Amygdaloid structure;Androgen Receptor;Anhedonia;antagonist;Anxiety;Automobile Driving;Behavior;Behavior assessment;Behavioral;Behavioral Assay;Binding;Brain;brain circuitry;Cell Physiology;chromatin immunoprecipitation;Chronic stress;Cytosol;Data;designer receptors exclusively activated by designer drugs;DNA;emotion regulation;experience;Female;Fright;Functional disorder;Funding;Gene Expression;Gene Targeting;Genetic;Glutamates;health disparity;hedonic;Hippocampus;Individual;innovation;interest;Knock-out;Major Depressive Disorder;male;men;Mental disorders;Mental Health;Molecular;Mood Disorders;Mus;National Institute of Mental Health;Neurobiology;Neurons;novel;novel therapeutic intervention;Nuclear;Nucleus Accumbens;patient subsets;pharmacologic;Pharmacology;Process;promote resilience;public health relevance;receptor function;Receptor Signaling;Research;resilience;response;Ribosomes;Role;sex;sex as a biological variable;Sex Differences;sexual disparity;Signal Transduction;Stress;stress resilience;System;Techniques;Testosterone;Therapeutic Intervention;therapeutic target;tool;Transgenic Mice;Translating;treatment strategy;Viral;Viral Vector;Woman;women patients;Work

PROJECT_TITLE: Projection-specific gene expression in resilience to chronic stress


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project narrative: Dying cells release several toxic components, including their bacterial-resembling power plants, mitochondria, a process known to promote inflammation and autoimmunity. However, we still do not fully understand how the released mitochondria contribute to inflammation and disease. In the current proposal, we aim to study how mitochondria are recognized and removed by our immune cells to avoid unwarranted inflammation, organ damage, and autoimmunity, with the ambition to identify novel pathways and biomarkers that could be targeted and monitored in mitochondrial-mediated diseases, in particular lupus.

PI_NAMEs: LOOD, JAN CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Aerobic;Affinity Chromatography;Anti-phospholipid Syndrome;Antibodies;Anticardiolipin Antibodies;Antigens;Autoantibodies;Autoantigens;Autoimmunity;Biological Markers;Biology;Blood Platelets;Cardiolipins;Cardiovascular Diseases;Cardiovascular system;Cells;Cessation of life;Clinical;Coagulation Process;cohort;Complement;Complement 1q;complement system;cytokine;Data;design;Development;Disease;Disease Management;Early treatment;Engineering;Excision;experimental study;Exposure to;extracellular;Flow Cytometry;Genome;human disease;Immune;Immune response;immunogenic;Impairment;In Vitro;in vivo;in vivo Model;Individual;Inflammation;Inflammatory;insight;Life;Lupus;lupus prone mice;Mass Spectrum Analysis;Mediating;Methionine;Mitochondria;Mitochondrial Proteins;Modeling;Monitor;mouse model;Mus;neutrophil;new therapeutic target;novel;novel marker;Organ;Outcome;Outcome Measure;Pathology;Pathway interactions;Patients;Phagocytosis;Phospholipids;phosphoproteomics;Platelet Activation;Power Plants;Preventive measure;Preventive treatment;Process;Production;prognostic;Prognostic Marker;Prokaryotic Cells;Property;Protein Biosynthesis;Reactive Oxygen Species;Research;Rheumatoid Arthritis;Risk Assessment;Role;Sampling;Signal Pathway;System;Systemic Lupus Erythematosus;Testing;therapeutic target;Thrombosis;Thrombus;venous thromboembolism;Venous Thrombosis;Work

PROJECT_TITLE: Role of mitochondria in SLE and its cardiovascular complications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-B(02)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: XIE, YANG  (contact)

PROJECT_TERMS: algorithm development;Algorithms;analytical tool;anti-cancer research;Applications Grants;Area;artificial intelligence algorithm;Big Data;Bioinformatics;Bioinformatics Shared Resource;bioinformatics tool;Biological;biomarker discovery;biomarker validation;Biostatistics Shared Resource;Biotechnology;cancer imaging;Catchment Area;Cells;Clinical Data;clinical predictive model;Clinical Trials Design;Commuting;Comprehensive Cancer Center;Computer Analysis;computer infrastructure;Computer software;Computer Systems;computerized tools;Consultations;cost effective;Data;Data Analyses;Data Analytics;Data Commons;data exchange;data integration;data management;Data Management Resources;Data Science;Data Set;data sharing;Databases;Development;digital;Doctor of Philosophy;Education;Educational workshop;Electronic Health Record;experience;Experimental Designs;Faculty;Funding;Generations;Genetic;Genomics;Goals;Grant;High Performance Computing;high throughput screening;Human Resources;Image;Informatics;informatics infrastructure;informatics tool;Infrastructure;innovation;Institution;Journals;Leadership;live cell imaging;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Medical center;member;Methodology;microbiome;Modernization;Molecular;Molecular Profiling;Names;Nature;NCI Center for Cancer Research;novel;Oncology;operation;Outcome;Peer Review;Population Sciences;Preparation;Principal Investigator;Process;programs;Proteomics;Publications;Publishing;Quality Control;Renal Carcinoma;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;research study;Resource Sharing;Resources;risk prediction model;Science;Secure;Series;Services;single cell genomics;single cell sequencing;skills;success;Systems Integration;Technology;Texas;Tissue imaging;Tissues;tool;Training;Training Programs;user-friendly;web portal;web services;Work

PROJECT_TITLE: Data Science Shared Resource

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer;Clinical Research;Lymphatic Research;Skin Cancer

ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: NARRATIVE This research is aimed at understanding how immune cells that fight tumors can remain in skin, lymph nodes, and blood, and how they defend against cancer. Results from this work will help to explain what helps immune cells localize to places where cancer spreads to prevent metastasis. In addition to studying cancer in mice, we will also study tissues from patients with melanoma and lung cancer, therefore this work has broad relevance for public health.

PI_NAMEs: TURK, MARY JO  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Anatomy;Antigens;Blood;Cancer Patient;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Compartmentation;Cells;Cementation;Characteristics;Circulation;Clinical;Clonal Expansion;Computer Analysis;Cutaneous Melanoma;cytokine;Data;Data Analyses;Dendritic Cells;DNA;draining lymph node;Drug or chemical Tissue Distribution;Excision;Exhibits;fighting;Gene Expression Profile;Generations;Geography;Goals;Homing;Human;Immune;Immune Tolerance;Immunity;Immunologic Surveillance;Interferons;Invaded;Learning;Link;Location;Long-Term Survivors;Lymph Node Tissue;lymph nodes;Lymphoid Tissue;Macrophage;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mediator;Melanoma;Melanoma patient;Melanoma Tumor;Memory;Metastatic Melanoma;Metastatic Neoplasm to Lymph Nodes;migration;Movement;Mus;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;novel;Operative Surgical Procedures;Pathway interactions;Patients;Peripheral;Population;Positioning Attribute;prevent;Primary Neoplasm;Production;Productivity;prognostic significance;public health relevance;Regulatory T-Lymphocyte;Research;residence;Residencies;Resistance;response;Role;Shapes;Signal Transduction;Site;Skin;Skin Tissue;Source;Specimen;stemness;Stimulator of Interferon Genes;Survivors;T cell response;T-Lymphocyte;Testing;The Cancer Genome Atlas;Tissue Expansion;tissue resident memory T cell;Tissues;trafficking;tumor;tumor growth;Tumor Immunity;tumor progression;Tumor-Derived;Virus Diseases;Work

PROJECT_TITLE: Tissue Resident memory T cell responses to cancer

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


PI_NAMEs: POSNER, BRUCE ARTHUR (contact)

PROJECT_TERMS: Address;anti-cancer research;Applied Research;Artificial Intelligence;assay development;Award;bench to bedside;Biochemical;Biochemistry;Bioinformatics;Biological;Biological Assay;cancer cell;Cancer Center Support Grant;cancer imaging;Cancer Model;Cancer Research Project;Cell model;Cells;Cellular biology;Chemicals;cheminformatics;Chemistry;Clinical Oncology;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Comprehensive Cancer Center;CRISPR screen;Data Analyses;Data Collection;data management;Data Storage and Retrieval;Databases;design;Detection;detection assay;Development;Doctor of Philosophy;Dose;Drug Design;drug discovery;end of life;Ensure;experience;Follow-Up Studies;functional genomics;Funding;Future;genome-wide;Genomic Library;Goals;Grant;high throughput screening;Human Resources;Immunotherapy;improved;Infrastructure;innovation;instrument;instrumentation;Investigational Therapies;Investments;Journal of the National Cancer Institute;Journals;Laboratories;lead optimization;Legal patent;Libraries;Light;Machine Learning;Malignant Neoplasms;Management Information Systems;Mass Spectrum Analysis;Medical center;member;Methods;Nature;novel;novel therapeutics;Paper;Pathway interactions;Pharmacology;Phenotype;pre-clinical;Preclinical Drug Development;programs;Publications;Research;Research Personnel;Resource Sharing;Resources;response;Retrieval;Science;Scientific Advances and Accomplishments;Scientist;screening;Screening Result;Services;skills;small molecule;small molecule inhibitor;small molecule libraries;Statistical Methods;Structure;Structure-Activity Relationship;success;System;Technology;Therapeutic;Therapeutic Intervention;three-dimensional modeling;Time;tool;Training;Translating;translational medicine;Translational Research;tumor microenvironment;tumor progression;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: High Throughput Screening Shared Resource


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

PHR: Project Narrative: The incidence of type 1 diabetes (T1D), an autoimmune disease which affect millions of people worldwide, has been rising for the past half century. While both genetic and environmental factors contribute to the risk of developing T1D, recent studies indicate that early-life microbial interactions with the developing immune system offer a critical window of opportunity to influence the immune system development and prevent disease. Our study uses a new mouse model of the early-life microbiome, derived from a line of mice that are genetically protected from T1D, to identify immunomodulatory commensal bacteria and immune system pathways that can be used to develop effective preventative therapies for T1D.

PI_NAMEs: GREEN, JAMAL  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Affect;Age;Alleles;Animal Model;Antibiotic Therapy;Antibodies;Antibody Response;Antigen Presentation;Antigens;Aptitude;Autoimmune Diseases;Autoimmunity;Bacteria;Binding;career development;CD4 Positive T Lymphocytes;Cell Compartmentation;Childhood;clinically relevant;commensal bacteria;Communication;Communities;Data;Development;Diabetes Mellitus;diabetes mellitus therapy;diabetic;Disease;disease model;Environmental Risk Factor;Event;experimental analysis;Experimental Designs;experimental study;Fellowship;Flow Cytometry;Genetic;genetic association;Genetic Models;germ free condition;Germ-Free;Gnotobiotic;Goals;Growth;gut colonization;gut microbes;gut microbiome;gut microbiota;Haplotypes;high risk;Human;Immune;Immune system;Immunoglobulin A;Immunology;Immunophenotyping;immunoregulation;improved;Inbred NOD Mice;Incidence;innovation;insight;Insulin-Dependent Diabetes Mellitus;insulitis;Intestines;Investigation;Laboratories;Life;Major Histocompatibility Complex;Measures;Medical;Mentorship;metagenomic sequencing;Metagenomics;MHC Class II Genes;Microbe;microbial;microbial colonization;microbiome;microbiota;microorganism antigen;microorganism interaction;Modeling;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;Non obese;novel;Pathway interactions;Patients;Pennsylvania;Peripheral;Persons;Physicians;Population;prevent;Preventive measure;Preventive therapy;programs;Publishing;Regulatory T-Lymphocyte;Resources;response;restoration;Risk;Scientist;Shapes;skills;Structure;System;Systems Development;T-Lymphocyte;Technical Expertise;Techniques;Training Programs;transgene expression;Transgenic Organisms;Universities;Weaning

PROJECT_TITLE: Major Histocompatibility Complex Shapes Early Life Microbial Events to prevent Autoimmunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07-U(20)L]


NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: METTLEN, MARCEL BERNARD (contact)

PROJECT_TERMS: Aging;Animals;Award;Binding;Biomedical Engineering;Biomedical Research;cancer cell;Cancer Center Support Grant;Cells;Cellular biology;cellular imaging;Communication;Comprehensive Cancer Center;Computer software;Consult;Consultations;Custom;Data Analyses;Development;digital imaging;Doctor of Philosophy;Educational Background;Educational workshop;experience;Experimental Designs;Fiji;Fluorescence;fluorescence microscope;Funding;Goals;histological stains;Image;Image Analysis;image processing;Imaging technology;innovation;Institution;Instruction;instrument;instrumentation;Journals;Laboratories;Lasers;Leadership;Licensing;Light;Light Microscope;light microscopy;Lighting;live cell imaging;Malignant Neoplasms;Medical center;member;Microbiology;Microscope;microscopic imaging;Microscopy;Nature;NCI Center for Cancer Research;new technology;operation;Optics;Photons;Principal Investigator;programs;Publications;Research;Research Personnel;Resource Sharing;Sampling;Scanning;Science;Services;Site;Slice;Spectrum Analysis;superresolution imaging;Techniques;Technology;Thick;three dimensional structure;Tissue imaging;Tissues;tool;Training;Translations;two-photon;ultra high resolution;United States National Institutes of Health;Vendor

PROJECT_TITLE: Quantitative Light Microscopy Shared Resource


PI_NAMEs: MASON, RALPH P. (contact)

PROJECT_TERMS: Acetates;American;anatomic imaging;Anatomy;Animal Experimentation;Animal Housing;animal imaging;Animals;anti-cancer research;Area;Award;Biodistribution;Budgets;Cancer Biology;Cancer Center Planning Grant;Cancer Center Support Grant;cellular imaging;Chemicals;Choline;Clinic;clinical investigation;Clinical Trials;Communication;community center;Companions;Comprehensive Cancer Center;Consult;Consultations;cost;Cyclotrons;Data;Development;Doctor of Philosophy;Drug Kinetics;Drug Targeting;Ensure;Equipment;Ethics;Evaluation;experience;fluorodeoxyglucose;Functional disorder;Funding;Gastroenterology;Genetic Engineering;germ free condition;Goals;Grant;Image;image guided;imaging approach;imaging biomarker;Imaging Device;imaging facilities;imaging modality;Imaging Techniques;Imaging technology;Immunooncology;ImmunoPET;improved;in vivo;Individual;Infrastructure;insight;instrument;instrumentation;Intervention;Investigation;irradiation;Isotopes;Journals;Label;Laboratories;Leadership;Link;Magnetic Resonance Imaging;Malignant Neoplasms;Medical center;meetings;member;Metabolism;Methods;Misonidazole;molecular imaging;Multimodal Imaging;National Cancer Institute;Nature;NCI Center for Cancer Research;Neurosciences;novel;novel strategies;novel therapeutic intervention;novel therapeutics;nuclear imaging;optical imaging;Optics;optoacoustic tomography;outreach;Peer Review;Performance;PET/CT scan;pre-clinical;precision oncology;Prognostic Marker;programs;Publications;Publishing;Radiation;Radiochemistry;Radioisotopes;Radiolabeled;Reagent;receptor;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Series;Services;single photon emission computed tomography;Small Animal Imaging Shared Resource;Societies;success;symposium;Technology;Testing;theranostics;Therapeutic;Therapeutic antibodies;tool;Tracer;Training;Translational Research;Translations;treatment response;tumor;tumor hypoxia;Ultrasonography;ultrasound;Visualization;Work

PROJECT_TITLE: Small Animal Imaging Shared Resource


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Millions of people experience general anesthesia each year in the United States, yet the mechanisms governing anesthetic actions are unclear. The period of arousal from anesthesia, termed emergence, is a particularly sensitive and dangerous time in clinical anesthesia care, and no therapeutic strategy currently exists for modifying emergence. This proposal aims to elucidate inhibitory cellular, circuit, and behavioral mechanisms of emergence from general anesthesia in order to inform the development of mechanistically targeted interventions.

PI_NAMEs: HESHMATI, MITRA  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Agitation;Anesthesia procedures;Anesthetics;Area;Arousal;awake;Behavior;Behavioral;Behavioral Mechanisms;Brain;Caring;Cell Adhesion Molecules;cell type;Cells;Clinical;Dangerousness;Delirium;design;Development;Disease;Electrophysiology (science);Equilibrium;experience;Foundations;General Anesthesia;Genes;Inhibitory Synapse;Intervention;Investigation;knock-down;life span;Light;Machine Learning;Maps;Mediating;Microscopy;mouse model;Mus;neuroligin 2;Neurons;optical sensor;Outcome;Patients;Persons;Pharmacologic Substance;postsynaptic;pre-clinical;Pre-Clinical Model;programs;Research;Resolution;Rodent Model;scaffold;Signal Transduction;single cell sequencing;Stress;Synapses;synaptic function;Synaptic plasticity;Therapeutic;Time;transcriptome sequencing;United States;Work

PROJECT_TITLE: Mechanisms of emergence from general anesthesia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]