NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Tobacco;Tobacco Smoke and Health;Transplantation

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Cigarette smoke exposure induces corneal edema and worse the severity of corneal endothelial dystrophies. This project aims to identify novel cellular pathway modulators and iPSC-derived corneal endothelial cells as treatment modalities. This research has the potential to address the limited availability of donor tissue and graft rejection in subjects with a smoking history.

PI_NAMEs: RIAZ, MUHAMMAD ALI (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Adherent Culture;Advocate;Affect;Animal Model;anterior chamber;Attenuated;Blindness;Carbon Monoxide;Cell Culture Techniques;Cell Density;Cell Line;Cell Therapy;Cells;Cigarette;cigarette smoke;cigarette smoke-induced;Clinical;Complex Mixtures;Cornea;Corneal Diseases;Corneal edema;Corneal Endothelium;CRISPR/Cas technology;Critical Pathways;Data;Data Set;Descemet's membrane;Diabetes Mellitus;Disease;Early treatment;Edema;effective therapy;efficacy evaluation;Endothelial Cells;endothelial dysfunction;experimental study;exposure to cigarette smoke;Eye;Eyedrops;fly ash;Genetic;Goals;Graft Rejection;high risk;Human;human embryonic stem cell;human induced pluripotent stem cells;Hydration status;In Vitro;in vivo;Individual;induced pluripotent stem cell;inhibitor;Injection of therapeutic agent;Injections;insight;Keratoplasty;Knowledge;Lead;Mediating;Methodology;minimally invasive;Modality;Molecular;Monkeys;Morbidity - disease rate;Natural regeneration;Nicotine;novel;novel therapeutics;NQO1 gene;Oryctolagus cuniculus;Outcome;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Patients;pre-clinical;Pre-Clinical Model;Proteome;Reporter;Repression;Research;response;restoration;screening;Severities;Signal Pathway;Signal Transduction;Smoking History;Source;stem cells;Structural Protein;Techniques;Therapeutic;Tissue Donors;Tissues;Topical application;Toxin;Transplantation Surgery;Treatment Efficacy;Validation

PROJECT_TITLE: Exploring novel modulators for rescuing cigarette smoke-induced corneal edema and examining iPSC-derived corneal endothelial cells as a treatment modality


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Kidney Disease;Machine Learning and Artificial Intelligence;Pediatric;Prevention

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Children with chronic kidney disease (CKD) pose unique challenges to the health care system, which must address not only the primary kidney disorder, but the many extrarenal manifestations which include social function and emotional wellbeing, risk for cardiovascular disease and metabolic bone disease and a high mortality rate in young adulthood. The CKiD study is a landmark cohort study of children with CKD, having rallied more than 50 pediatric nephrology centers across the US and Canada to recruit and study 1100 children with mild to moderate CKD. From 2023 to 2028, the Clinical Coordinating Centers will continue to coordinate study visits with the following long term goals: enhance the current cohort to collect additional data as the new and existing cohorts become young adults; define how risk factors for GFR decline, and early cardiovascular abnormalities detected during childhood ultimately impact long-term health outcomes after transition to adulthood; examine the impact of risks developed during childhood CKD on outcomes in adulthood by linking CKiD data with external sources; and assess the social functioning and emotional well-being of children with CKD to understand their impact on subsequent clinical care and life course.

PI_NAMEs: FURTH, SUSAN L. (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: 17 year old;Acceleration;Achievement;Acute Renal Failure with Renal Papillary Necrosis;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Affect;African American;Age;Ancillary Study;Behavioral;biobank;Biological Markers;Birth;Blood Vessels;bone health;calcification;Canada;Cardiac;Cardiovascular Abnormalities;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Caring;Cellular Phone;Child;Child Welfare;Childhood;Chronic Kidney Failure;Chronic Phase;Clinical;clinical care;clinical center;Clinical Markers;clinical phenotype;Clinical Research;cohort;Cohort Studies;Collaborations;Communities;Computers;Contractor;coronary artery calcium;Data;Data Collection;Death Rate;design;Development;Diagnosis;Dialysis procedure;Disease;disease diagnosis;Disease Outcome;Disease Progression;DNA;Education;electronic data capture system;Electronic Health Record;Eligibility Determination;Emotional;Enrollment;Ensure;Equation;ethnic diversity;Evaluation;Event;Family;follow-up;functional decline;Functional disorder;Genetic study;Glomerular Filtration Rate;Goals;Health;Healthcare Systems;Heart Atrium;High Prevalence;Home;Home Blood Pressure Monitoring;hypertension treatment;improved;indexing;Individual;Information Systems;International;Joints;Kidney;Kidney Diseases;Kidney Transplantation;Laboratories;Leadership;Left;Life Cycle Stages;Link;Machine Learning;machine learning prediction;male;Measurement;Measures;Metabolic;Metabolic Bone Diseases;Metabolic Marker;Methodology;Methods;Midwestern United States;Monitor;Myocardial;Myocardium;Natural History;Nephrology;Neurocognitive;North America;novel;Online Systems;Organ;Outcome;Participant;Patient Recruitments;patient retention;Performance;Persons;Plasma;Population;Predictive Value;Process;Puberty;Publications;Quality of life;racial diversity;Readiness;recruit;Relaxation;Renal function;Renal Replacement Therapy;Reporting;Research;Research Personnel;Research Priority;Resources;Risk;Risk Assessment;Risk Factors;Role;Serum;Severities;Site;social determinants;Social Functioning;Source;Standardization;Statistical Methods;Structure;Symptoms;time interval;Training;transition to adulthood;Urine;validation studies;Ventricular;virtual;Visit;Well in self;Writing;young adult;Youth

PROJECT_TITLE: Chronic Kidney Disease in Children (CKiD)


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: UM1 NARRATIVE The Colorado Clinical and Translational Sciences Institute (CCTSI) is a Partnership among University of Colorado Denver’s two campuses, University of Colorado Boulder, Colorado State University, five hospitals and multiple community organizations committed to translating discoveries into better, equitable public health and patient care for all. Through innovative programs and collaborations to advance clinical and translational science, the CCTSI will facilitate the performance of high impact research and the training of the next generation of clinical-translational researchers. Team science, reducing health disparities and being poised to respond to a public health emergency will be emphasized. Ongoing evaluation and quality improvement will assure maximum efficiency and impact of our programs.

PI_NAMEs: HIGGINS, JANINE A;SOKOL, RONALD J. (contact)

PROGRAM_OFFICER_NAME: CURE, PABLO

PROJECT_TERMS: Abbreviations;Acceleration;Address;Adult;Advisory Committees;Applications Grants;authority;Biomedical Research;Biometry;career development;Center for Translational Science Activities;Child;Clinical;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials;Collaborations;collaborative environment;college;Colorado;Communities;community engagement;community organizations;community partnership;community research;Contracts;COVID-19 pandemic;Data Science;data sharing;design;Discipline of Nursing;Diverse Workforce;Education;Effectiveness;electronic data;Electronic Health Record;Environment;Epidemiology;Equity;Evaluation;Exposure disparity;Faculty;Funding;Funding Opportunities;Future;Goals;Grant;Health;Health Alliance;health data;health disparity;health inequalities;Health system;Healthcare;Hospitals;Ice;improved;Informatics;Infrastructure;innovation;Innovation Corps;Institution;Institutional Review Boards;Jews;Lead;Maps;Maternal and Child Health;Medical;Medical center;medical schools;Mentored Clinical Scientist Development Program;Mentors;Methodology;minority communities;Minority Groups;Monitor;next generation;Outcomes Research;pandemic disease;Patient Care;Pediatric Hospitals;Performance;Pharmacologic Substance;Pharmacy Schools;Play;pre-doctoral;Process;process improvement;Program Development;programs;Public Health;public health emergency;Public Health Informatics;Public Health Schools;Reduce health disparities;Research;Research Design;Research Personnel;Research Support;Research Training;resilience;response;Review Committee;Role;Rural Community;Rural Population;Safety;School Dentistry;Science;Site;skills;Special Population;success;System;Technology;Time;TNFSF15 gene;Training;Training Programs;Translating;translational impact;Translational Research;translational scientist;Translations;Underserved Population;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Vision;Workforce Development


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Sequence-based assays provide a powerful toolset for gaining insight into the function and disfunction of cancer cells. Unfortunately, the resulting data sets are a classic example of “big data” and experimental biologists are traditionally not trained to handle or analyze them. The goal of this R50 proposal is to provide Dr. Bartom’s expertise in both computation and biology to the cancer research programs of the Robert H. Lurie Comprehensive Cancer Center, and more specifically to the Quantitative Data Sciences Core (QDSC).

PI_NAMEs: BARTOM, ELIZABETH THOMAS (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Area;Award;Base Sequence;Big Data;Bioinformatics;Biological Assay;Biology;cancer cell;Cancer Center;Cancer Patient;Cancer Research Project;Cell Culture Techniques;Cell Physiology;Center Core Grants;Chromatin;Comprehensive Cancer Center;Computer Analysis;Data;Data Science Core;Data Set;Defect;Development;Epigenetic Process;Functional disorder;Funding;Gene Activation;Genetic Transcription;Goals;Grant;high standard;Human;Human Herpesvirus 8;improved outcome;insight;Investigation;Kaposi Sarcoma;Malignant Neoplasms;member;molecular dynamics;Mutation;next generation sequencing;Patients;Pharmacologic Substance;programs;Regulation;Reproducibility;Research;Research Personnel;Role;Toxic effect;Transcription Elongation;Universities;Work

PROJECT_TITLE: Bioinformatics Analysis of Next Generation Sequencing Data from Cancer Cells


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Hormones control important biological processes through proteins called nuclear receptors, which are targetted by ~16% of drugs used in the clinic. This proposal takes aim at making never seen observations of a model nuclear receptor named RORγT interacting with and manipulates chromatin. By incorporating novel biological contexts and using interdisciplinary structural biology techniques to study RORγT structure, function, and regulation, this work has the potential to open novel areas of investigation in NR biology, has broad implications to human health and physiology, and may also facilitate the development of chemical modulators with more efficacy and fewer side effects.

PI_NAMEs: STRUTZENBERG, TIMOTHY SILAS (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Adaptive Immune System;antimicrobial;Area;Autoimmune Diseases;Binding;Biochemical;Biochemistry;Biological;Biological Assay;Biological Process;Biology;Biophysical Process;biophysical techniques;Biophysics;birth control;Chemicals;Chromatin;Chromatin Structure;Chronic;Chronic small plaque psoriasis;Clinic;Clinical;Clinical Trials;Complement;Complex;crosslink;Cryoelectron Microscopy;Data;design;Deuterium;Development;Disease;DNA;drug development;Drug Targeting;Drug usage;Enzymatic Biochemistry;EP300 gene;fighting;Foundations;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Goals;Health;Histone Acetylation;histone modification;Histones;Home;Hormones;Human;Hydrogen;Immunity;improved;Industrialization;Inflammatory;insight;Investigation;Laboratories;Laboratory Study;Length;Libraries;Ligands;Mass Spectrum Analysis;Measurement;Mediating;member;Metabolic Diseases;Metabolism;Methodology;Modeling;Modification;Molecular;Molecular Conformation;Monitor;Names;Nature;NCOA3 gene;next generation sequencing;novel;Nuclear Receptors;Nuclear Structure;Nucleosomes;orphan nuclear receptor ROR-gamma;Pathology;Physiology;Play;Positioning Attribute;Post-Translational Protein Processing;preference;programs;protein complex;Protein Dynamics;Proteins;Proteomics;receptor;Receptor Activation;receptor binding;reconstitution;recruit;Regulation;Reproduction;Research;Resolution;Response Elements;Role;Safety;Side;side effect;Solvents;structural biology;Structure;T cell differentiation;targeted treatment;Techniques;Technology;therapeutic target;Thymus Gland;Training;training project;transcription factor;Transcriptional Activation;Vertebral column;Work;Writing

PROJECT_TITLE: Interrogating the Structural Basis of Nuclear Receptor Activation on Chromatin


ADMINISTERING_IC: DA

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Data Science;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Alleviating the burden of neurological and psychiatric disorders will require a cohort of investigators who can use computational and theoretical tools to understand brain function in health and disease. This program will train undergraduates and graduate students to use quantitative modeling combined with advanced statistical and machine learning methods for analysis of large datasets to reveal features of brain function and disease not possible without these quantitative approaches.

PI_NAMEs: MILLER, PAUL  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Attitude;Behavior;Biology;career;Cognition;Collaborations;computational neuroscience;computer science;Computing Methodologies;Coupled;Data;Data Analyses;design;Disease;doctoral student;Eligibility Determination;Ensure;experience;Faculty;Funding;Goals;graduate student;Health;Human;Individual;Institution;interdisciplinary collaboration;Knowledge;laboratory experience;Laboratory Research;Learning;Machine Learning;mathematical model;Mathematics;Mentors;Methods;model building;Molecular;National Institute of Drug Abuse;National Research Service Awards;Nervous System;Neurons;Neurosciences;outreach;pre-doctoral;programs;Prospective cohort;Psychology;Research;Research Project Grants;Science;Scientist;Senior Scientist;skills;statistics;Students;Synapses;Teacher Professional Development;Training;Training Programs;undergraduate student;Underrepresented Populations;Universities;Work;Writing

PROJECT_TITLE: Undergraduate and Graduate Training in Computational Neuroscience and Data Analysis


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Colon cancer is the fourth deadliest cancer with ~150,000 new cases and 53,000 deaths in the US in 2021. Colon cancers develop by selection of oncogenic mutations in stem cells of morphologically normal epithelium. This proposal seeks to identify the role of immune system in suppressing selection of mutated stem cells in the colon with the goal of developing treatment strategies to prevent colon cancers.

PI_NAMEs: MIRZA, HARIS  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Anatomy;Architecture;base;Bayesian Method;Blocking Antibodies;Cancer Etiology;cancer initiation;Cancerous;career development;Cell Proliferation;cell type;Cells;Cellular Morphology;Cessation of life;Clone Cells;Colon;colon cancer prevention;Colon Carcinoma;Colonic Neoplasms;Colonoscopy;cytokine;Data;Development;Diagnosis;Disproportionately impacts women;epithelial stem cell;Epithelium;Evolution;experimental study;Goals;Histologic;Human;human old age (65+);Immune;Immune system;Immunologic Surveillance;Immunoprevention;In Vitro;Incidence;Individual;Infiltration;Interleukin-10;interleukin-10 receptor;intestinal crypt;Label;Lesion;Major Histocompatibility Complex;Malignant Neoplasms;Mentors;Molecular;Morphology;mouse model;Mucous Membrane;Mus;mutant;Mutate;Mutation;neoplastic;Oncogenes;Oncogenic;Organoids;Pathway interactions;Patients;Physicians;premalignant;prevent;Prevention strategy;Prevention therapy;Program Development;Proliferating;Regulation;Regulatory T-Lymphocyte;Reporter;Research;Research Personnel;Role;Scientist;segregation;Shapes;Signal Transduction;stem cell biology;stem cells;Supporting Cell;T cell infiltration;T-Cell Depletion;T-Lymphocyte;Techniques;Testing;Therapeutic;Time;Training Programs;transcriptomics;treatment strategy;Tube;tumor;tumor immunology;tumor microenvironment;tumor-immune system interactions;Woman;Work

PROJECT_TITLE: Immune control of oncogene selection in preneoplastic colon

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Data Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative The ﬁeld of neuroscience is experiencing a renaissance in terms of the scale and complexity of the datasets that are now routinely collected. It is crucial that the next generation of neuroscientists are able to synthesize, organize, and model these datasets, with the goal of building new theories of the brain. The central goal of our training program will be to train the next generation of neuroscientists with the strong quantitative skills needed to advance the ﬁeld.

PI_NAMEs: DOIRON, BRENT D. (contact);MACLEAN, JASON NEIL;PALMER, STEPHANIE E

PROJECT_TERMS: Appointment;Behavior;Behavioral;Biology;Brain;brain dysfunction;Chicago;Code;Communities;Competence;Complement;computational neuroscience;computer program;computer science;Data;Data Set;Differential Equation;Discipline;Doctor of Philosophy;Dryness;Educational Status;Electronics;Engineering;Ensure;Environment;experience;experimental study;Exposure to;Faculty;Fostering;Funding;Genetic;graduate student;Human;Interdisciplinary Study;Journals;Laboratories;laboratory experiment;Mathematics;Microscopy;Minor;Minority Recruitment;Modeling;National Research Service Awards;neural;Neurobiology;neuromechanism;Neurons;Neurosciences;Neurosciences Research;next generation;programs;Psychology;Research;Research Personnel;Research Project Grants;responsible research conduct;Schools;Series;Statistical Methods;statistics;Students;summer program;System;Teacher Professional Development;Techniques;theories;Training;Training Programs;undergraduate research experience;undergraduate student;Universities;Work

PROJECT_TITLE: Training in Theory and Computation for Next Generation Neuroscientists


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Substance Misuse;Telehealth

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT RELEVANCE  Ten percent of Americans meet criteria for an alcohol use disorder, with rising levels of problematic drinking during the COVID-19 pandemic. Novel strategies, including leveraging telehealth, are needed to bring effective interventions to the millions of people in the US who experience problems with alcohol. We propose to investigate the efficacy and cost-effectiveness of an incentive intervention called contingency management that will be delivered via telehealth using a novel alcohol biomarker called phosphatidylethanol (PEth), and we will also identify factors that predict long-term abstinence during a 12-month follow-up period.

PI_NAMEs: HILL-KAPTURCZAK, NATHALIE ;MCDONELL, MICHAEL G (contact);MURPHY, SEAN M.

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Abstinence;addiction;Adult;Affect;Aftercare;alcohol abstinence;Alcohol consumption;alcohol intervention;alcohol use disorder;Alcohols;American;Biological;Biological Markers;Blood;Blood specimen;blood-based biomarker;Caring;cigarette smoking;Clinical;Clinical effectiveness;Cognitive Therapy;Collection;contingency management;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;COVID-19 pandemic;Devices;drinking;Drug usage;economic evaluation;effective intervention;Effectiveness;Emotional;executive function;experience;feasibility trial;follow-up;Frequencies;Glucuronides;Health Care Costs;Health Care Sector;Heavy Drinking;improved;incentive salience;Incentives;Individual;Intervention;intervention participants;Legal;Length;long term abstinence;long term recovery;Longitudinal Studies;Medical Care Costs;Medical Device;Mental Health;Modeling;Monitor;National Institute on Alcohol Abuse and Alcoholism;novel;novel strategies;Observational Study;Outcome;Outcome Assessment;pandemic disease;Participant;Patient Self-Report;Patients;Persons;Phase;phosphatidylethanol;physical conditioning;pilot trial;Policy Maker;Prediction of Response to Therapy;Predictive Factor;primary outcome;Productivity;programs;Psychological reinforcement;Public Health;Quality-Adjusted Life Years;Randomized;recruit;reinforcer;Reporting;Research;Resources;safety net;Sampling;satisfaction;Savings;secondary outcome;Smoking;social stigma;Stigmatization;Substance Use Disorder;telehealth;Testing;Time;treatment as usual;Treatment outcome;Urine;virtual;Visit;Vocation

PROJECT_TITLE: Assessing the Clinical and Cost-Effectiveness of a Virtual PEth-based Contingency Management for Adults with AUD

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN DIEGO

ORG_NAME: ORIGAMI THERAPEUTICS, INC.

PHR: NARRATIVE Huntington’s disease (HD) is an inherited, debilitating, and fatal neurodegenerative disease for which there is no effective treatment. HD is caused by a mutation in the huntingtin gene, which is essential for normal body and brain function, however, in patients with HD, the huntingtin protein is susceptible to misfolding that results in nerve cell dysfunction and cell death. Origami Therapeutics, Inc. has developed and will test and then select an orally available drug that lowers the levels of the toxic misfolded huntingtin protein, eliminating the cause of HD as a potential treatment to prevent HD progression, morbidity, and mortality.

PI_NAMEs: HOFFMAN, BETH J (contact);PRIGOZHINA, NATALIE

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: ABCB1 gene;absorption;ADME Study;analog;Animal Model;Area;Aspiration Pneumonia;Atrophic;Autophagocytosis;autosome;Binding Proteins;Biological Assay;Biological Availability;Blood;Blood Tests;Brain;CAG repeat;Cell Death;Cell Differentiation process;Cell division;Cell Physiology;Cells;Cerebral cortex;Cerebrospinal Fluid;Chemicals;Clinical;clinical translation;Clinical Trials;Cognitive deficits;commercialization;Corpus striatum structure;curative treatments;Cystic Fibrosis;design;Development;Disease;Disease Progression;DNA Damage;Dose;drug candidate;Drug Compounding;Drug Kinetics;effective therapy;efficacy evaluation;efficacy testing;Excretory function;Family;Fibroblasts;Functional disorder;gain of function;gene discovery;Gene Proteins;Genes;Genetic;Genetic Transcription;Glutamine;Grant;Heart Diseases;Histopathology;Human;Huntington Disease;Huntington gene;In Vitro;in vivo;in vivo evaluation;Individual;induced pluripotent stem cell;Inherited;innovation;insight;Intravenous;Investigational New Drug Application;Lead;Legal patent;Length;Liver Microsomes;Mass Spectrum Analysis;Measures;Medical;Metabolism;Mitochondria;Modality;Morbidity - disease rate;mortality;Motor;mouse model;Mus;mutant;Mutation;N-terminal;Nervous System Disorder;Neurites;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;Neurons;neuroprotection;novel therapeutic intervention;Operative Surgical Procedures;Oral;Oral Administration;Organ;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Penetration;Peripheral;Persons;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;Physiology;Plasma Proteins;polyglutamine;Post-Translational Protein Processing;potential biomarker;pre-clinical;Predisposition;Prevalence;prevent;Procedures;Prognosis;programs;Property;Proteins;research clinical testing;response;Rest;Safety;safety assessment;safety study;scaffold;screening;Signal Transduction;Skeletal Muscle;Small Business Innovation Research Grant;small molecule;Solubility;Stretching;Symptoms;Synaptic Transmission;System;Testing;Therapeutic;therapeutic target;Therapeutic Uses;Time;Tissues;Toxic effect

PROJECT_TITLE: Characterization of small molecules that lower mutant huntingtin protein as potential therapeutics for Huntington’s disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-P(11)B]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Lung;Physical Activity;Pulmonary Hypertension

ORG_CITY: SAINT PAUL

ORG_NAME: MINNESOTA HEALTHSOLUTIONS CORPORATION

ORG_STATE: MN

PHR: Project Narrative Long-term oxygen therapy is widely prescribed for people with chronic lung or heart diseases. In the U.S., there are 1.5 million people on long-term oxygen therapy. An improved oxygen control system that optimizes oxygen delivery, particularly when used outside the home when patients are physically active, is needed and would improve the patient quality of life.

PI_NAMEs: RYDBERG, NICK  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Activities of Daily Living;Address;Aglaia;Air;Algorithms;American;Anxiety;Asthma;Automation;Blood;Cellular Phone;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical Research;Collaborations;commercialization;Companions;Computer software;Coupled;design;Development;Device or Instrument Development;Engineering;Esters;Evaluation;Exercise Tolerance;Exertion;Family member;follower of religion Jewish;Fright;Goals;Health;health related quality of life;Healthcare;Heart Diseases;Home;human study;Hunger;Hyperoxia;Hypoxemia;improved;innovation;Interstitial Lung Diseases;Knowledge;Lung Diseases;Manuals;Mechanics;Medical History;member;Metabolic;Minnesota;mobile computing;Modality;novel;Overdose;Oxygen;Oxygen Therapy Care;Patient Care;Patient Compliance;Patient-Focused Outcomes;Patients;Persons;Phase;phase 1 study;Physical activity;Physiologic pulse;Polycythemia;portability;Principal Investigator;Production;prototype;Pulmonary Fibrosis;Pulmonary Hypertension;Quality of life;Reporting;research and development;Resources;Rest;right ventricular failure;smartphone application;Social Impacts;Social isolation;Software Engineering;Source;Specific qualifier value;Spottings;Standardization;Strenuous Exercise;System;Technology;Time;Training;Walking;wasting;Well in self

PROJECT_TITLE: Automated Long-Term Oxygen Therapy Control System


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Clinical Research;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative Research in neuroscience is crucial for attacking the causes of neurological and mental health disorders. If the field of neuroscience is to continue its rapid advance, neuroscientists must use, understand, and develop new technologies, acquire and analyze ever larger data sets, and grapple more directly with the complexity of neurobiological systems. The primary goal of this training program is to train a new generation of interdisciplinary neuroscientists with strong quantitative skills.

PI_NAMEs: CHASE, STEVEN M (contact);TORRES-OVIEDO, GELSY

PROJECT_TERMS: academic minor;Appointment;Artificial Intelligence;Biomedical Research;Brain;Brain Diseases;Clinical Research;Cognition;college;computational neuroscience;computer science;data modeling;Data Set;Doctor of Philosophy;doctoral student;Environment;experience;Faculty;Fostering;Goals;Growth;Interdisciplinary Study;Internet;Machine Learning;Minority-Serving Institution;neural;neuromechanism;Neurosciences;programs;recruit;Research;Research Personnel;Schools;Students;summer program;tool;Training;Training Programs;undergraduate student;United States;Universities

PROJECT_TITLE: Interdisciplinary Training in Computational Neuroscience


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE The proposed research seeks to elucidate the role of endothelial Activin signaling in age-related heart failure with preserved ejection fraction (HFpEF). This research plan is relevant to public health because it is expected to lead to advance our understanding of cardiovascular diseases in older adults, and develop potential novel therapeutics for age-related HFpEF, a leading cause of morbidity and mortality in older adults. Thus, it accomplishes the National Institute on Aging’s missions and initiatives by not only providing novel molecular and cellular mechanism in pathological aged mice, but also potential therapeutic advancements that can improve the longevity and functional capacity in older adults.

PI_NAMEs: XIA, PENG  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acceleration;activin A;Activins;Activities of Daily Living;Advisory Committees;age acceleration;age related;aged;Aging;aging process;Area;Attenuated;Automobile Driving;Biology;Biology of Aging;Blood Vessels;Cardiac;cardiac aging;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;career;career development;Cell Aging;Cells;Chronic;Clinical;Communities;Complex;Coronary;Data;design;Development;Doctor of Philosophy;EFRAC;Elderly;Endothelial Cells;Endothelium;Environment;FDA approved;Fostering;Foundations;frailty;Functional disorder;functional restoration;Funding;Future;General Hospitals;Genetic Transcription;Goals;Heart;Heart failure;Human;ICAM1 gene;Image;imaging modality;Immune;improved;in vivo Model;Incidence;Inflammation;Inflammatory;inhibitor;innovation;instructor;International;Investigation;knowledge base;Lead;Leukocytes;Longevity;Massachusetts;Mediating;Mediator;medical schools;Medicine;Mentors;Methods;middle age;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;Myocardial dysfunction;Myocarditis;nanoparticle;National Institute on Aging;NF-kappa B;novel;novel strategies;novel therapeutics;old mice;older adult;p65;paracrine;Pathologic;pathological aging;Pathway interactions;Patients;Pharmacological Treatment;Phenotype;Phosphorylation;Physiological;Play;Positioning Attribute;preservation;Process;programs;Property;Public Health;Receptor Activation;Receptor Inhibition;Receptor Signaling;recruit;Regulation;Research;Research Personnel;response;Role;Science;senescence;Signal Induction;Signal Transduction;skills;Stress;Syndrome;Therapeutic;therapeutic target;Training;Transgenic Organisms;translational potential;Type II Activin Receptors;United States National Institutes of Health;Vascular Endothelial Cell;vascular inflammation;Work

PROJECT_TITLE: The role of endothelial ActRII signaling in age-related Heart Failure with preserved Ejection Fraction (HFpEF)

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: INDIANAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Alzheimer’s disease affects as many as 5 million individuals over the age of 65 in the United States and 35 million worldwide. The best treatment is prevention, which requires objective diagnostic tools for early detection. To this end, the proposed research aims to identify novel imaging biomarkers obtained with magnetic resonance imaging as early differential diagnostic tools.

PI_NAMEs: WU, YU-CHIEN  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Address;Affect;Age Months;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Animal Model;Area;Autopsy;Autoradiography;Axodendritic Synapse;Axon;behavior test;Binding;Brain;Characteristics;Clinical;Cognitive;cognitive function;cost;Dendrites;density;Deposition;Development;diagnostic criteria;diagnostic tool;Diffuse Axonal Injury;Diffusion;Diffusion Magnetic Resonance Imaging;Disadvantaged;Disease;Early Diagnosis;Electrophysiology (science);Future;Glycoproteins;Goals;Hippocampus;Human;human old age (65+);Image;imaging biomarker;Imaging Techniques;Impaired cognition;in vivo;Individual;Ionizing radiation;Knowledge;Laboratories;Learning;Ligand Binding;Ligands;Magnetic Resonance Imaging;Measures;Memory;Memory Loss;mild cognitive impairment;mild traumatic brain injury;Modeling;Modernization;Molecular;Monitor;Morphology;mouse model;Mus;Neurites;Neurodegenerative Disorders;normal aging;novel;Outcome;Outcome Measure;Participant;Performance;Phase;Positron-Emission Tomography;pre-clinical;Prevention;Prognosis;Progressive Disease;Proxy;Radiation exposure;Radiopharmaceuticals;radiotracer;Reporting;Research;Resolution;Sampling;Senile Plaques;Signal Transduction;Stains;Structure;Synapses;Synaptic plasticity;Synaptic Vesicles;Techniques;Time;tool;Tracer;United States;Validation;Verbal Learning;white matter

PROJECT_TITLE: Assessing Diffusion MRI Metrics for Detecting Changes of Synaptic Density in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Physical Activity;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative This project will evaluate the effectiveness of The National Diabetes Prevention Program (NDPP) when delivered by U.S. Cooperative Extension staff to adults with prediabetes in rural areas and compare active and passive strategies for participant recruitment. If this approach is effective, delivery of the NDPP through Cooperative Extension has the potential to improve access and sustainability of the NDPP for the prevention of Type 2 diabetes in underserved rural areas across the U.S.

PI_NAMEs: GORCZYCA, ANNA MICHAEL (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: Address;Adult;Advertising;Age;Agriculture;arm;Body Weight;Body Weight Changes;Body Weight decreased;Centers for Disease Control and Prevention (U.S.);Clinic;Collaborations;compare effectiveness;comparison intervention;Control Groups;cost;cost comparison;cost effective;cost effectiveness;County;County Government;demographics;Development;Diabetes Mellitus;diabetes prevention program;Distance Learning;Education;Educational Curriculum;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness/implementation trial;Electronic Health Record;Electronic Mail;Eligibility Determination;Enrollment;Ethnic Origin;evidence base;Fatty acid glycerol esters;Food;Frequencies;Funding;Glycosylated hemoglobin A;Goals;Grant;Hemoglobin A;high risk;Improve Access;improved;Incidence;Income;Individual;information gathering;Intake;Intervention;intervention cost;intervention delivery;intervention participants;Interview;Kansas;Life Style;lifestyle intervention;Maintenance;male;Mediator;meetings;Methods;Minority Groups;Monitor;Non-Insulin-Dependent Diabetes Mellitus;Participant;Patient Recruitments;Physical activity;Population;Practical Robust Implementation and Sustainability Model;Prediabetes syndrome;Prevalence;prevent;Prevention;Prevention program;primary outcome;Program Sustainability;programs;Protocols documentation;Race;Randomized;Recommendation;recruit;Recruitment Activity;remote delivery;Research;Rural;rural area;Rural Community;rural counties;rural dwellers;rural health clinic;Schedule;secondary outcome;Self Direction;Services;sex;Site;Structure;Techniques;Time;Training;treatment arm;underserved rural area;Universities;urban area;Weight Gain;weight loss program

PROJECT_TITLE: The National Diabetes Prevention Program in Rural Communities

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Dissemination and Implementation Research;Health Services;Hearing Loss;Infectious Diseases;Networking and Information Technology R&D (NITRD);Neurosciences;Otitis Media;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: NARRATIVE Hearing loss in infants is a “developmental emergency”, and early hearing detection, intervention, and hearing loss prevention are central to national strategies for ear and hearing care. Building on collaborations with the Technical Working Group for Ear and Hearing Care in Kenya’s Ministry of Health, we will optimize and test implementation outcomes for smartphone-based universal hearing screening for newborns and infants. Among infants with HIV exposure, a population of interest for hearing surveillance, we will deploy serial hearing screening coupled with simple smartphone-based detection of middle ear fluid and determine rates of otitis media with effusion, a modifiable risk factor for early hearing loss.

PI_NAMEs: BENKI-NUGENT, SARAH F. (contact);GALLAGHER, EMILY ;NDEGWA, SERAH

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 5 year old;Acute;Address;Adopted;Adoption;Affect;Age;Age Months;aged;Audiology;Birth;Caring;Cellular Phone;Child;Childhood;childhood hearing loss;Chronic;Clinical;Collaborations;community clinic;Community Health Aides;Companions;computer science;computer scientist;Conductive hearing loss;cost;Country;Coupled;Data;deaf;Detection;Development;Devices;Diagnosis;disability;Ear;Early Diagnosis;Early Intervention;Early treatment;Economics;Education;electronic medical record system;Emergency Situation;Environment;Epidemiology;Equipment;Evaluation;Exhibits;experience;Exposure to;Financial Hardship;Foundations;Friends;Goals;Health;Health care facility;Hearing;Hearing Aids;hearing impairment;hearing loss risk;hearing screening;high risk;high risk infant;HIV;Hospitals;Human Resources;implementation evaluation;implementation outcomes;implementation science;implementation strategy;improved;Incidence;Income;Infant;Infection;Inflammation;innovation;interest;Intervention;Kenya;Life;Liquid substance;Location;Longitudinal Studies;low and middle-income countries;Medical;mHealth;middle ear;middle ear fluid;modifiable risk;Monitor;Neonatal Screening;Neurocognitive;Newborn Infant;Noise;Nurses;open source;Otitis Media;Otitis Media with Effusion;otoacoustic emission;Otolaryngology;ototoxicity;Outcome;Patients;Pediatrics;Penetration;permanent hearing loss;Persons;Population;preference;prenatal exposure;prevent hearing loss;Program Sustainability;programs;Protocols documentation;Provider;Public Health;public health relevance;Reporting;Research;Research Personnel;Resource-limited setting;Resources;Risk;Risk Factors;scale up;School-Age Population;screening;screening program;Screening Result;Sensitivity and Specificity;Services;skills;Social Development;Surveys;Techniques;Testing;Time;tool;Training;usability;user-friendly;willingness;Work;working group

PROJECT_TITLE: mHealth OAE: Towards Universal Newborn Hearing Screening in Kenya (mTUNE)


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_NAME: CONSEGNA PHARMA, INC.

PHR: PROJECT NARRATIVE While naloxone is an effective opioid overdose antidote, in many cases its short half-life is ineffective against synthetic opioids with longer half-lives, such as fentanyl, leading to a phenomenon called renarcotization (whereby an overdose patient revived with naloxone re-enters an overdose state from residual opioid in the body after the naloxone wears off). The objective of this project is to create a better pharmacokinetic profile for naloxone delivery that continuously maintains naloxone at therapeutic levels long enough to prevent renarcotization. This novel product will directly lead to saving lives of opioid overdose victims.

PI_NAMEs: ZANA, LAWRENCE J (contact)

PROGRAM_OFFICER_NAME: NGUYEN, TAM L

PROJECT_TERMS: Acceleration;Acute;Address;Advanced Development;Agitation;American;Animals;antagonist;Antidotes;Applications Grants;canine model;Canis familiaris;Cardiovascular system;Caring;Cessation of life;Chemicals;Clinical;Clinical Research;commercialization;Complication;Cyclic GMP;Dangerousness;Data;Dehydration;Delirium;design;Development;Documentation;Dosage Forms;Dose;Drops;Drug Delivery Systems;Drug Kinetics;Drug Packaging;efficacy study;Electrolytes;Emergency medical service;Encapsulated;Excretory function;FDA approved;Fentanyl;first responder;Formulation;Future;Goals;Half-Life;Hospitals;Hour;in vivo;Individual;innovation;Intellectual Property;Investigational Drugs;Investigational New Drug Application;Legal patent;Life;manufacture;manufacturing process;manufacturing scale-up;Medical;meetings;Metabolism;Monitor;mortality;mu opioid receptors;nalmefene;Naloxone;naloxone dosing;novel;Opiate Addiction;Opioid;Opioid Antagonist;opioid overdose;opioid withdrawal;Outcome;Overdose;Overdose reduction;Overdose reversal;particle;Patients;Pharmaceutical Preparations;Phase;Poison;Poisoning;pre-Investigational New Drug meeting;prevent;Procedures;Process;Production;programs;Public Health;Pulmonary Edema;Regulatory Pathway;research and development;Research Design;Residual state;Risk;rural area;safety study;Sales;Secure;Shapes;Small Business Innovation Research Grant;Symptoms;synthetic opioid;Temperature;Testing;Therapeutic;Toxicology;United States National Institutes of Health;Ventilatory Depression;Vomiting;warfighter;weapons;Work;Writing

PROJECT_TITLE: IND-enabling development of a long-duration antagonist to treat opioid overdose


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MAYWOOD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: PROJECT NARRATIVE Adaptation of coronaviruses to human transmission and virulence present continuous threat to global health. SARS-CoV-2 and all other coronaviruses adapt primarily through variations in the conformationally dynamic and very large multidomain S glycoproteins that mediate virus-cell entry. As S protein complexity leaves the biological impacts of many such adaptative variations enigmatic, we propose to use diverse virus entry assays to elucidate mechanisms by which changes in the membrane fusion – inducing domains reset viral dynamics and cell entry properties in ways that may increase transmission or virulence.

PI_NAMEs: GALLAGHER, THOMAS MILLER (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Affinity;Amino Acid Substitution;Amino Acids;Animals;Antibodies;Apical;Binding;Biochemical;Biological;Biological Assay;Cell membrane;Cells;Collection;Communication;Communities;Complex;conformational conversion;Coronavirus;Coronavirus spike protein;Detection;Distant;driving force;Endocytosis;Engineering;Equilibrium;Evaluation;Evolution;Future;global health;Glycoproteins;Goals;Human;Infection;inhibitor;insight;Kinetics;Link;Measures;Mediating;Membrane Fusion;Middle East Respiratory Syndrome Coronavirus;Molecular Conformation;Mutation;Pathway interactions;Peptide Hydrolases;Peptides;Predisposition;Property;Protein Conformation;Protein Dynamics;Proteins;receptor;receptor binding;Receptor Cell;recombinant virus;Recombinants;Replicon;Resistance;resistance mutation;SARS-CoV-2 B.1.1.529;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Site;Structure;Surface;System;tool;transmission process;Variant;variants of concern;Viral;Viral Drug Resistance;viral fitness;Virulence;Virus;Virus Receptors;Virus Shedding;virus tropism;Virus-like particle

PROJECT_TITLE: Impacts of Adaptive Coronavirus Evolution on Viral Membrane Fusion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VDT-Q(01)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Genetics;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Linking the evolution of cognitive abilities to genetic differences between humans and nonhuman primates is challenging since it requires an understanding of how life experiences induce changes in brain activity and neuronal gene expression. We will use experimental methods in primary and stem cell-derived neuronal cultures to investigate how neuronal activity-responsive regulatory elements differ between humans and other primates, and we will create machine learning models to predict the location of these elements in the genome. Since many neurodevelopmental disorders are thought to involve disruptions in neuronal plasticity, understanding the molecular and cellular mechanisms of plasticity in human neurons will be crucial to understanding both the evolutionary specializations of the human brain and to developing treatments for neurological disorders.

PI_NAMEs: POLLARD, KATHERINE S.;POLLEN, ALEXANDER A (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Address;Atlases;Autopsy;Behavioral;Biological Assay;Biological Models;Brain;Chromatin;Cognitive;cognitive ability;comparative;Computer Models;Computing Methodologies;convolutional neural network;CRISPR interference;Data;Data Set;Development;developmental plasticity;Diploidy;Disease;Elements;Enhancers;Evolution;experience;flexibility;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic study;Genetic Variation;Genome;genome-wide;Genomics;Human;In Vitro;Induced pluripotent stem cell derived neurons;innovation;Life Experience;Link;Location;Macaca;Macaca mulatta;Machine Learning;machine learning model;Mediator;Methods;Modeling;Molecular;Mutation;Nervous System Disorder;Neurodevelopmental Disorder;Neuronal Plasticity;Neurons;nonhuman primate;Pan Genus;Pattern;Phase;Phenotype;Phylogeny;Physiological;Prevalence;Primates;Property;Regulatory Element;Reporter;Resources;response;Sequence Analysis;sequence learning;single-cell RNA sequencing;Slice;species difference;Statistical Data Interpretation;stem cells;Stimulus;Training;Variant

PROJECT_TITLE: Discovering human divergent activity-regulated elements using comparative, computational, and functional approaches

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative  This application, Phase 2 of the EFIRM-Liquid Biopsy Research Laboratory is to advance liquid biopsy for early lung cancer detection by: 1) advance the EFIRM Liquid Biopsy (eLB) technology towards ultra-sensitive detection of cancer-associated cfDNA directly in a droplet of blood while 2) a new landscape of cancer biomarkers, ideal for eLB detection, will be developed that will provide optimal coverage for early lung cancer detection.

PI_NAMEs: ABERLE, DENISE R.;HSU, WILLIAM ;KRYSAN, KOSTYANTYN ;STROM, CHARLES MARTIN;WEI, FANG ;WONG, DAVID T (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: Address;Algorithms;Benign;Biological Assay;Biological Markers;Blood;Blood specimen;Blood Volume;Cancer Biology;cancer biomarkers;Cancer Detection;cancer diagnosis;Cancer Patient;candidate marker;cell free DNA;Characteristics;chest computed tomography;circulating DNA;Classification;Clinical;cohort;Collaborations;computed tomography screening;curative treatments;Data;deep learning;Detection;Development;Diagnosis;Diagnostic;Diagnostic tests;Diameter;Diffusion;Disease;DNA Sequence Alteration;Early Diagnosis;electric field;Engineering;Ensure;former smoker;frontier;Heterogeneity;histological specimens;Human;Image;improved;Individual;Industry;industry partner;interest;Laboratories;Laboratory Research;Lesion;liquid biopsy;Liquid substance;low dose computed tomography;Lung;lung cancer screening;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;malignant state;Measurement;Methods;Methylation;MicroRNAs;Modeling;Molecular;mortality;multiple omics;never smoker;Nodule;Non-Malignant;Non-Small-Cell Lung Carcinoma;novel;Pathologic;Patients;Performance;Phase;Plasma;point of care;Population;pre-clinical;prediction algorithm;Predictive Cancer Model;predictive modeling;Procedures;prospective;Prospective cohort;Qualifying;radiomics;Recommendation;reconstruction;Research;Resolution;Scanning;screening;Secure;serial imaging;Signal Transduction;Somatic Mutation;surveillance imaging;Symptoms;Techniques;Technology;Testing;Thoracic Radiography;Tissue Sample;tumor DNA;Tumor Markers;Validation;X-Ray Computed Tomography

PROJECT_TITLE: EFIRM Liquid Biopsy Research Laboratory: Early Lung Cancer Assessment


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Primary Health Care

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Even before COVID-19, pneumonia with respiratory failure was a very common cause of hospitalization in the United States. Unfortunately, many patients who survive pneumonia have persistent health problems for months or years afterwards. The goal of this Effective Primary Care Practices that Enhance Recovery Trajectories after Pneumonia (EXPERT) study is to use appreciative inquiry to help primary care clinicians take better care of pneumonia patients–by taking a strengths-based approach for transformational change to design and test a new systems-level intervention.

PI_NAMEs: HOUGH, CATHERINE LEE;IWASHYNA, THEODORE J (contact);TAYLOR, STEPHANIE P

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Address;Advance Care Planning;Caring;clinical epidemiology;Clinical Trials;COVID-19;Critical Care;Data;Data Set;design;Disease;Electronic Health Record;experience;Focus Groups;follow-up;Goals;Health;Health system;hospital readmission;Hospitalists;Hospitalization;Hospitals;implementation determinants;improved;improved outcome;Informatics;innovation;insight;Intervention;intervention refinement;Interview;Knowledge;Link;long term recovery;Malignant Neoplasms;Measures;Medical Sociology;medical specialties;Medicine;Methods;Myocardial Infarction;novel;Outcome;Palliative Care;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physical therapy;pilot trial;Pneumonia;post-COVID-19;pragmatic randomized trial;Primary Care;primary care clinician;primary care practice;primary care services;primary care team;Process;process improvement;prototype;public health priorities;Randomized;Recovery;Research;Respiratory Failure;Sepsis;Site;Stroke;Structure;Survivors;System;Testing;trial design;United States;user centered design;Work

PROJECT_TITLE: Effective Primary care practices that Enhance Recovery Trajectories after pneumonia (EXPERT)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-P(90)S]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Dietary Supplements;Eye Disease and Disorders of Vision;Neurosciences;Nutrition

ORG_CITY: CLEVELAND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE The membrane protein STRA6 facilitates vitamin A uptake into the eyes. Emerging evidence indicates that disturbance in this process is associated with inherited and chronic disease. Defining the molecular and biochemical foundation of ocular vitamin A import and export is desirable to assist the development of therapeutic intervention against blinding disorders.

PI_NAMEs: VON LINTIG, JOHANNES FRIEDRICH (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 11 cis Retinal;absorption;Adolescence;Adult;Affect;All-Trans-Retinol;alpha-carotene;Architecture;basolateral membrane;Beta Carotene;Binding;Biochemical;Blood-Retinal Barrier;Bruch's basal membrane structure;chromophore;Chronic;Chronic Disease;Chylomicrons;Clinical Research;clinically relevant;Complex;Cone;dietary;Dietary Intervention;Disease;Dose;Enterocytes;Esters;Etiology;Eye;Eye Development;Eye diseases;Fat-Soluble Vitamin;Foundations;Funding;Genetic;genetic approach;Goals;Health;Hepatic;Hereditary Disease;high resolution imaging;Homeostasis;Hormones;Human;human induced pluripotent stem cells;Imaging Techniques;Impairment;improved;induced pluripotent stem cell;Inherited;innovation;Intestines;Knockout Mice;Knowledge;Life;Light;lipoprotein lipase;Liver;loss of function;Maintenance;Mammals;Mediating;Membrane;Membrane Proteins;Metabolism;Methodology;Molecular;monolayer;mouse model;Mus;Night Blindness;novel;Organizational Change;organizational structure;Outcome;Oxygenases;Pathologic;Pathway interactions;Patients;Peripheral;Photoreceptors;Physiological;Pigments;Play;Positioning Attribute;Process;Production;Provitamin A Carotenoid;RBP4 gene;Reagent;receptor;Regulation;Research;Research Design;Retina;Retinal Cone;retinal neuron;Retinal Pigments;retinal rods;Retinitis Pigmentosa;Retinoids;Retinol Binding Proteins;Role;Signal Transduction;Structure;Structure of retinal pigment epithelium;Supplementation;Syndrome;System;therapeutic development;Therapeutic Intervention;Tight Junctions;Tissues;tool;transcription factor;Transgenic Mice;Tretinoin;uptake;Vertebrate Photoreceptors;Vision;Visual impairment;Vitamin A;Vitamin A Deficiency

PROJECT_TITLE: STRA6 and Ocular Vitamin A Homeostasis

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: Chicago

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative: Efficient delivery of drugs for ocular inflammatory diseases will benefit a lot by developing new drug delivery systems that provide sustained release of any drug of choice. Proposed studies will demonstrate that activated carbon particles can be used to deliver anti-inflammatory drugs in a sustained fashion to suppress ocular inflammation.

PI_NAMEs: YADAVALLI, TEJABHIRAM  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acyclovir;Adolescent;Adrenal Cortex Hormones;Adsorption;Affect;Age;analog;Anti-Inflammatory Agents;Anti-viral Agents;Antiinflammatory Effect;antimicrobial;Area;Bacteria;Benzalkonium Chloride;Blindness;Carbon;Cells;Characteristics;Child;clinical efficacy;clinically relevant;common treatment;Cornea;Cyclosporine;Data;Dermatitis;design;Dexamethasone;Dialysis procedure;Disease;dosage;Dose;Drug Delivery Systems;drug efficacy;Drug Kinetics;drug release profile;Drug usage;efficacy evaluation;Encapsulated;Eye;Eye Development;Eye Infections;Eyedrops;Formulation;Frequencies;fungus;Genetic;Glucocorticoids;Goals;Herpes Simplex Infections;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;Herpetic Keratitis;Hour;Human;Implant;improved;In Vitro;in vivo;in vivo Model;Individual;Infection;Inflammation;Inflammatory;Intellectual Property;Interleukin-1 beta;Keratitis;Knowledge;Legal patent;Light;lymphadenopathy;Mechanics;microbial;Modality;Modeling;mouse model;Mus;National Eye Institute;next generation;novel;novel therapeutics;ocular pain;Oral;Paper;particle;Particle Size;pathogen;Patient Compliance;Patients;Persons;Pharmaceutical Preparations;Physiological;Porosity;Prednisone;Primary Infection;Publishing;Recurrence;Regimen;Reporting;Research;Risk;Sampling;Science;Severities;Simplexvirus;Site;standard of care;Standardization;Structure;Surface;System;Techniques;Testing;Therapeutic;Time;Tissues;Topical application;Topical Corticosteroids;treatment duration;Treatment Protocols;Tube;Ulcer;Universities;Viral;Virus;Virus Replication;Vision

PROJECT_TITLE: DECON: A sustained topical delivery platform to treat ocular inflammation

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: The studies proposed in this application address the molecular and cellular mechanisms responsible for the formation and maintenance of the light-sensitive compartment of vertebrate photoreceptor cells, the outer segment. Because of adverse effects of daily light exposure, the outer segment material has to be replaced approximately every ten days; this requires an exquisite efficiency and precision in performance of the molecular machinery responsible for supporting the integrity of this cellular compartment. Dysfunction of outer segment morphogenesis causes some of the most severe types of inherited retinal degeneration, which highlights the significance of our proposed studies for developing strategies of disease prevention and future therapeutic intervention.

PI_NAMEs: ARSHAVSKY, VADIM Y (contact);CALVERT, PETER DEANE

PROJECT_TERMS: Actins;Address;Adverse effects;base;Behavior;Biology;Biophysics;Cell membrane;cell motility;cell type;Cells;Cellular biology;Cilia;Complex;Cytoskeleton;Defect;depolymerization;disorder prevention;Electron Microscopy;Etiology;experimental study;fascinate;Fluorescence Microscopy;Frequencies;Functional disorder;Functional Imaging;Future;Genes;Genetically Modified Animals;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Image;Impairment;inherited retinal degeneration;Knock-out;Laboratories;Light;light adverse effect;light microscopy;Maintenance;Mammals;Mass Spectrum Analysis;Mediating;Membrane;Metabolism;Methodology;Modeling;Molecular;Monomeric GTP-Binding Proteins;Morphogenesis;Mus;Organelles;Performance;Periodicals;Periodicity;Phosphatidylinositols;phosphoinositide-3,4,5-triphosphate;Phosphoric Monoester Hydrolases;Phosphotransferases;photoreceptor cell outer segment;photoreceptor degeneration;photoreceptor disc;Photoreceptors;Phototransduction;polymerization;Polymers;Positioning Attribute;Process;programs;protein complex;Protein Dephosphorylation;Proteins;Rana;recruit;Regulation;Research;Role;sensor;Signal Pathway;Site;Structure;Structure of retinal pigment epithelium;Surface;Therapeutic Intervention;Time;Transgenic Mice;Transgenic Organisms;Vertebrate Photoreceptors;Vision;WAVE protein;Work;Xenopus

PROJECT_TITLE: Molecular mechanisms of photoreceptor disc morphogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-F(02)M]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE This project will advance understanding of the biological mechanisms contributing to cellular senescence, a known driver of aging and disease. Specifically, we will investigate the mechanisms by which mitochondrial double-stranded RNA contributes to the induction of pro-inflammatory genes in senescence and test the efficacy of genetic and pharmacological interventions to promote healthy aging. This knowledge could potentially lead to novel clinical treatments to counteract aging and age-related disease.

PI_NAMEs: PASSOS, JOAO  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: age related;age-related disease;Aging;aging related;BAX gene;Biological;Cell Aging;Cell Cycle Arrest;Cells;Chronic;Clinical Treatment;Cytosol;Data;Development;Disease;DNA;Double-Stranded RNA;drivers of aging;drug development;Drug Targeting;efficacy testing;experimental study;Functional disorder;Genes;Genetic;Genetic Transcription;Goals;healthspan;healthy aging;immunogenic;Impairment;improved;in vivo;Inflammation;Inflammatory;Inflammatory Response;innovation;interest;Intervention;Knowledge;Link;major outer membrane protein;Mediating;Minority;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial RNA;Mus;novel;novel therapeutics;Nuclear;Pathway interactions;pharmacologic;Phenotype;preservation;Process;Regulation;RNA;Role;senescence;senescence associated secretory phenotype;senescent cell;sensor;Stimulator of Interferon Genes;Structure;therapeutic target;tissue degeneration;Tissues;TLR3 gene;Transcript;Transfection;Tumor Suppression;Work

PROJECT_TITLE: Investigating the role of cytosolic mitochondrial double-stranded RNA in cellular senescence and aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE - OVERALL The purpose of this new, inter-institutional U54 application between San Diego State University (SDSU) and the University of California San Diego (UCSD) is to advance cancer health equity in underserved communities throughout the southern California border communities of San Diego and Imperial Counties. Under a new name – the Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership – the overarching goals are to further increase SDSU’s cancer research capacities and expand SDSU’s and UCSD’s emphasis on cancer health disparities research. Additional goals include developing cancer research opportunities and pathways for undergraduate, graduate, and medical students as well as early-stage investigators (ESIs), which will lead to a future workforce that is more diverse and reflective of the catchment- area population.

PI_NAMEs: CRIPPS, RICHARD MATTHEW;MADANAT, HALA ;MARTINEZ, MARIA ELENA (contact);MURPHY, JAMES D

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Advanced Malignant Neoplasm;agricultural community;Alaska Native;American Indians;anti-cancer research;Asian;Automobile Driving;Behavior;Black Populations;Border Community;Breast;California;Cancer Burden;cancer education;cancer health disparity;Cancer health equity;career;career development;Caring;Catchment Area;Cause of Death;Colorectal;Communities;community academic partnership;community advisory board;community engaged research;community engagement;County;design;Dissemination and Implementation;Education;education research;Equity;ethnic diversity;Ethnic Population;Evaluation;Evidence based intervention;experience;Fostering;Funding;Future;gastrointestinal;Goals;graduate student;health assessment;Health Disparities Research;health equity;Hispanic Populations;improved;Incidence;insight;Institution;inter-institutional;Leadership;Linguistics;Liver;Lung;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Students;Mentors;Minority;Names;Neighborhood Health Center;outreach;Pancreas;Pathway interactions;Pilot Projects;Population;population based;programs;Race;racial population;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Risk Factors;Rural;screening;Screening for cancer;survivorship;Teacher Professional Development;undergraduate student;Underrepresented Students;underserved community;Universities

PROJECT_TITLE: 2/2 Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: MARTINEZ, MARIA ELENA (contact)

PROJECT_TERMS: Administrative Efficiency;Advisory Committees;anti-cancer research;Asian Americans;base;California;Cancer Center;cancer education;cancer health disparity;career;career development;Catchment Area;Collaborations;college;Communication;Communities;community advisory board;Community Outreach;Comprehensive Cancer Center;education research;Ensure;Environmental Health;Equity;evidence base;experience;Faculty;Feedback;Funding;Future;Glues;Goals;graduate student;Grant;Health Disparities Research;health equity;Hispanic-serving Institution;Infrastructure;Institution;Leadership;Malignant Neoplasms;Mediation;Medical Students;meetings;member;mid-career faculty;National Cancer Institute;Native Americans;operation;outreach;Pacific Island Americans;Pathway interactions;Peer Review;Persons;Population;Positioning Attribute;Principal Investigator;programs;Provider;Recording of previous events;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Schools;Scientist;Services;Structure;synergism;System;Teacher Professional Development;undergraduate student;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Patient Safety;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects

ORG_CITY: TUCSON

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative When trauma is bad enough to paralyze a limb, there are many factors that play into the clinical assessment and prognosis for recovery; and nowadays, clinicians have many tests to assess one or another tissue type – but we do not have any test for the status of the nerve tissue usable before weeks of waiting. Nerves control everything in a limb, and without nerve input, a paralyzed limb is useless; severed nerves require urgent surgery whereas non-severed nerves are best left to recover on their own – and no test can tell the difference at the time of injury. We have found a commonly-used drug (4-aminopyridine), has the previously unknown effect of reactivating only non-severed nerves, and we propose a clinical trial to see if this drug can be used as a single-dose test for severed nerves in our trauma patients.

PI_NAMEs: ELFAR, JOHN  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: 4-Aminopyridine;Affect;Agreement;Animals;Belief;Classification;Clinical;Clinical assessments;clinical prognosis;Clinical Trials;Crossover Design;Data;Diagnosis;Diagnostic;Diagnostic Imaging;dosage;Dose;Drug usage;Esthesia;experience;FDA approved;Feeling;Functional disorder;healing;Hospitals;Hour;Human;Iatrogenesis;iatrogenic injury;imaging platform;improved;indexing;Injury;Institution;Institutional Review Boards;Intervention;Kinetics;Knowledge;Laboratories;Left;limb injury;Limb structure;Masks;Measures;Medicine;member;Modeling;Monitor;motor control;Motor Vehicles;Movement;Multiple Sclerosis;Muscle;Nerve;Nerve Crush;nerve injury;nerve repair;Nerve Tissue;neuronal excitability;novel;Operative Surgical Procedures;Oral Administration;Orthopedics;Outcome;Pain;Paralysed;Participant;Patients;Peripheral nerve injury;Peripheral Nerves;Pharmaceutical Preparations;pharmacologic;Placebos;Play;Population;Potassium Channel;primary outcome;Procedures;Prognosis;Property;Publishing;Randomized;Recording of previous events;Recovery;Recovery of Function;Renal clearance function;repaired;research clinical testing;Resort;response;Safety;Sensorimotor functions;Serum;Shock;Solid;standard care;standard of care;Stimulus;Surgeon;Surgical Injuries;Tendon Reflex;Testing;Time;tissue injury;Tissues;tool;Trauma;Trauma patient;treatment planning;ultrasound;usability;Withdrawal

PROJECT_TITLE: A Single Dose Pharmaco-Diagnostic for Peripheral Nerve Continuity After Trauma

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MURPHY, JAMES D (contact)

PROJECT_TERMS: Academia;Acceleration;Advocate;Affect;anti-cancer research;Applications Grants;Award;Biometry;California;cancer education;cancer health disparity;career;Career Mobility;Collaborations;commune;Communities;community building;community engaged research;Coupled;Dedications;design;Development;Doctor of Philosophy;early-career faculty;Education;education research;Environment;Equity;Ethnic Origin;evidence base;experience;Extramural Activities;Faculty;Feeling;Formulation;Funding;Future;graduate student;Grant;Grant Review;Health;Health Disparities Research;health equity;Health equity research;improved;innovation;Institution;Institutional Policy;Institutional Practice;intrinsic motivation;Leadership;Libraries;Malignant Neoplasms;Medical Students;Mentors;Mentorship;Modeling;novel;outreach;peer;Perception;Policies;Positioning Attribute;Productivity;Race;Research;Research Design;research faculty;Research Personnel;Research Project Grants;Research Proposals;Resource Sharing;Resources;Science;Services;skills;Statistical Data Interpretation;Stress;Structure;success;symposium;System;Teacher Professional Development;undergraduate student;underserved community;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: TALENT Shared Resources Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

PHR: Project Narrative We propose novel hardware and data acquisition strategies for next-generation causal mapping of the human cerebral cortex using transcranial magnetic stimulation (TMS) and high-resolution MRI. Leveraging our recent developments in MR-compatible TMS coils, we will develop a hybrid brain array of 48 coils for both TMS and noninvasive imaging that will be used to probe and map structural and functional changes in the living human brain at an unprecedented level of detail.

PI_NAMEs: BILGIC, BERKIN ;HUANG, SUSIE YI;NUMMENMAA, AAPO ;STOCKMANN, JASON P (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Acoustics;Amplifiers;Behavior;Benchmarking;Brain;Brain Mapping;Calibration;Cell Density;Cells;Cerebral cortex;Custom;Data;data acquisition;density;design;Development;Devices;Diffusion;Diffusion Magnetic Resonance Imaging;Electronics;Elements;experience;experimental study;feasibility testing;flexibility;Functional Magnetic Resonance Imaging;Geometry;Goals;Head;Heating;Human;human imaging;Hybrids;Image;Imaging Device;imaging system;improved;in vivo;Length;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mechanics;Methods;Microscopic;millimeter;Motor;Motor Cortex;neocortical;Nerve Fibers;neural;Neurites;neuroimaging;neuronal cell body;Neuronal Plasticity;Neurons;neuroregulation;Neurosciences;next generation;non-invasive imaging;novel;Pattern;Performance;Phase;Physiologic pulse;Play;prototype;Radial;radio frequency;reconstruction;Resolution;Somatosensory Cortex;Specific qualifier value;Structure;Surface;System;Technology;Testing;Therapeutic;tool;Transcranial magnetic stimulation

PROJECT_TITLE: Hybrid TMS/MRI system for regionally tailored causal mapping of human cortical circuits and connectivity


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Microbiome;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Alcoholic hepatitis (AH) is a severe, potentially life-threatening form of alcohol-associated liver disease (ALD) with limited therapeutic options. The proposed research focuses on studying the connection between alcohol-associated cholestasis and AH in a novel murine model for ALD. The proposed research is expected to lead to an important positive impact on the development of therapeutic strategies to improve outcomes in patients with AH.

PI_NAMEs: YAN, SHENGMIN  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Academia;Alcohol consumption;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Animal Model;Area;ATAC-seq;Award;Bile Acids;bile formation;Biliary;Bioinformatics;career;career development;Cholestasis;Chronic;chronic alcohol ingestion;chronic liver disease;clinical development;Data;Development;Diagnostic;Disease Progression;Dose;Epithelial Cells;Ethanol;expectation;experience;experimental study;Fatigue;Fatty Liver;fecal transplantation;Functional disorder;Goals;gut microbiome;gut-liver axis;Hepatic;Hepatitis;Hepatocellular Damage;HMGB1 gene;Icterus;Impairment;improved outcome;Inflammation;Inflammatory Response;Injury;insight;Intrahepatic Cholestasis;Knockout Mice;Knowledge;Leukotrienes;Life;Liver;Liver diseases;liver inflammation;liver injury;Mentors;metabolomics;Modeling;mouse model;Mus;Neutrophil Infiltration;novel;Organoids;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Positioning Attribute;pre-clinical;Predisposition;Principal Investigator;Prognosis;programs;Pruritus;Reproducibility;Research;Role;Scientist;Shapes;single-cell RNA sequencing;skills;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Training;transcriptome sequencing;transcriptomics;Yin

PROJECT_TITLE: Alcohol-associated cholestatic liver injury and mechanisms


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Pancreatic Cancer;Rare Diseases

PI_NAMEs: LOWY, ANDREW M (contact)

PROJECT_TERMS: 3-Dimensional;Acetylation;Actins;Adherence;Adhesions;Adhesiveness;Affect;African American;alpha Actin;American;anti-cancer research;Behavior;Binding;Biochemical;Biology;biophysical properties;Biophysics;cancer cell;cancer education;Cause of Death;Cell Adhesion;Cell Cycle Progression;Cell model;cell motility;Cell Nucleus;Cell Proliferation;Cells;Chemotherapy-Oncologic Procedure;Collaborations;Cytoplasm;Cytoskeleton;Cytosol;Data;depolymerization;Development;Disease;Disease Progression;effective therapy;Enhancers;Environment;Excision;experience;extracellular;Extracellular Matrix;F-Actin;Flavins;G Actin;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Goals;health equity;high risk population;Hispanic;Hospitals;Human;human disease;Impairment;improved;improved outcome;in vivo;Incidence;Insurance;Integrins;Invaded;Knowledge;Laboratories;Life;Link;Liver;Lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;mechanical properties;Mechanics;migration;Mixed Function Oxygenases;Morbidity - disease rate;mortality;myocardin;Myosin ATPase;Neoplasm Metastasis;new therapeutic target;Not Hispanic or Latino;novel therapeutic intervention;Nuclear;Nuclear Export;Nucleic Acid Regulatory Sequences;Outcome;Pancreas;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic stellate cell;Pathway interactions;patient population;Patients;Pattern;Phenotype;Play;Pre-Clinical Model;Primary Neoplasm;Property;Proteins;Reporting;Role;screening;Serum Response Factor;Signal Induction;Signal Transduction;Socioeconomic Status;Stromal Cells;Structure;Testing;therapeutic target;therapeutically effective;Transcription Coactivator;transcription factor;Transcriptional Regulation;tumor growth;tumor microenvironment

PROJECT_TITLE: Full Project 1: Defining Mechanisms of MICAL-dependent Pancreatic Cancer Cell Migration


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

PI_NAMEs: JAVIER-DESLOGES, JUAN FRANCISCO (contact)

PROJECT_TERMS: access disparities;Address;Adverse event;adverse outcome;anti-cancer research;beneficiary;California;cancer care;cancer education;cancer health disparity;Cancer Patient;cancer risk;care delivery;care outcomes;Caring;Catchment Area;Cohort Studies;Communication;Complement;County;COVID-19 pandemic;Data;Data Set;Databases;Development;Disparity;disparity reduction;Emergency department visit;Environment;Equity;ethnic minority;Ethnic Origin;experience;Future;health disparity;health equity;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Hospitalization;Hospitals;Household;Improve Access;improved;Income;Individual;Inequality;Inequity;interest;Internet;Intervention;Knowledge;Language;Link;Logistic Regressions;Low income;Malignant Neoplasms;marginalized population;Medicare;Medicare claim;Medicare/Medicaid;Methods;Modeling;neoplasm registry;older adult;older patient;Oncology;Outcome;pandemic disease;Patient Care;patient population;Patient-Focused Outcomes;patient-level barriers;Patients;Perception;Persons;Policies;Policy Maker;Population;population based;Populations at Risk;Positioning Attribute;post-COVID-19;Provider;provider-level barriers;Quality of Care;Race;racial minority;Research;response;Risk;Safety;Secondary to;Socioeconomic Status;Surveys;Technology;Telecommunications;telehealth;Testing;Visit;Vulnerable Populations

PROJECT_TITLE: Full Project 2: The Intersection of Telehealth and Health Disparities in At-Risk Older Patients with Cancer


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Assistive Technology;Behavioral and Social Science;Bioengineering;Chronic Pain;Clinical Research;Disability Research;Mental Health;Osteoarthritis;Pain Research;Precision Medicine;Rehabilitation

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Total joint arthroplasty is the most common orthopedic procedure for patients with refractory osteoarthritis, yet a significant number of patients fail to recover and develop chronic postsurgical pain (CPSP) following surgery. While risk factors for CPSP have been documented in this population, the mechanisms that promote resilience remain poorly characterized. Therefore, the goal of this project is to identify multisystem phenotypic profiles of resilience that predict postsurgical recovery trajectories in pain impact and physical function among adults undergoing knee and hip arthroplasty.

PI_NAMEs: BARTLEY, EMILY J. (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adult;Affect;Age;Arthritis;Behavioral;Biological;Characteristics;Chronic;Chronic disabling pain;Chronic low back pain;chronic pain;chronic painful condition;cognitive function;Consensus;decrease resilience;Degenerative polyarthritis;depressive symptoms;Development;Dimensions;disability;Exhibits;experience;functional disability;global health;Goals;Health;health care service utilization;Hip region structure;hip replacement arthroplasty;improved;Individual;individual patient;innovation;insight;Intervention;Investigation;Joints;Knee;knee replacement arthroplasty;Knowledge;Literature;Measures;Mental Depression;Modality;Modeling;Nature;novel;Observational Study;older adult;Operative Surgical Procedures;opioid use;optimism;Orthopedic Procedures;Orthopedic Surgery;Outcome;Pain;pain adaptation;pain catastrophizing;pain model;pain relief;patient subsets;Patients;Pattern;Perioperative;Persistent pain;Persons;Phenotype;Physical Function;Population;Postoperative Pain;Postoperative Period;postoperative recovery;precision medicine;Precision Medicine Initiative;Prediction of Response to Therapy;Predictive Factor;Procedures;Process;promote resilience;prospective;protective effect;protective factors;psychologic;Psychosocial Factor;Recovery;Refractory;Replacement Arthroplasty;Research;resilience;resilience factor;Resources;response;Risk Factors;risk stratification;Role;Sampling;Severities;Site;social;Social support;Sociology;Source;Stress;success;symptomatology;Symptoms;System;Techniques;Theoretical model;therapeutic development;Time;tool;trait;treatment response;United States;Work

PROJECT_TITLE: A Multisystem Resilience Approach in the Assessment of Postsurgical Pain Trajectories


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE HIV prevention among young women in East and southern Africa is paramount to curbing the global epidemic and the advent of HIV pre-exposure prophylaxis (PrEP) with daily medication has been only mildly helpful given its reliance on daily medication use. New PrEP products that are used every month (a vaginal ring) or 2 months (an injectable) could reduce compliance challenges and lead to greater HIV prevention coverage. In a set of implementation science driven studies in Kenya with collaborating public reproductive health clinics, we will address unanswered questions about how to optimize incorporation of new PrEP products and the degree to which the availability of additional products impacts HIV protection coverage.

PI_NAMEs: HEFFRON, RENEE A. (contact);MUGO, NELLY RWAMBA

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Adherence;Advocate;Age;AIDS prevention;antenatal;Atopobium vaginae;Behavioral Sciences;Blood;Caring;Client;Clinic;Clinical;clinical epidemiology;Clinical Trials;Cluster randomized trial;Collaborations;community based research;community consultation;Consolidated Framework for Implementation Research;Contraceptive Agents;Counseling;Country;Dapivirine;Dependence;design;Diphosphates;Drops;Educational Materials;Effectiveness;Eligibility Determination;Epidemic;experience;Exposure to;Family Planning;Female Adolescents;Focus Groups;Frequencies;Guidelines;Healthcare;HIV;Human immunodeficiency virus test;implementation science;improved;Incidence;Individual;Injectable;Injections;interest;Intervention;Interview;Intramuscular Injections;Kenya;Length;Measures;member;Methods;Oral;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pill;Population;pre-exposure prophylaxis;Prevention;Process;product development;programs;Protocols documentation;Provider;Qualitative Research;Randomized;Randomized, Controlled Trials;Recommendation;Reproductive Health;Reproductive Health Services;Research;Research Methodology;Residual state;Risk;Safety;scale up;secondary outcome;Services;Sex Behavior;Sexual Health;Social support;Southern Africa;supply chain;System;Tenofovir;Time;Training;unintended pregnancy;uptake;Vaginal Ring;Woman;Work;young woman

PROJECT_TITLE: Effectiveness of PrEP product choice on HIV prevention coverage among young women in Kenya seeking reproductive health services


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative There is a need for imaging markers to hep prognosticate progression to Alzheimer’s Disease (AD). We propose the use of a novel method, named Magnetic Resonance Spectroscopic Fingerprinting (MRSF), to assess changes in the cellular microenvironment which contribute to AD. In combination with positron emission tomography and blood plasma measurements, we hypothesize that MRSF will provide new markers for predicting neurodegeneration and cognitive decline.

PI_NAMEs: KIROV, IVAN IVANOV (contact);TAL, ASSAF

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta accumulation;Address;Alzheimer's Disease;Alzheimer's disease pathology;American;Amyloid beta-Protein;Appearance;Astrocytes;Atrophic;Axonal Transport;Basic Science;Biochemistry;Biological Markers;Brain;Cell Physiology;cell type;Cells;Clinical;Cognitive;cognitive function;cohort;comparison control;Complement;cost effective;Cytoskeleton;Data;Deposition;Disease;disease prognosis;Disease Progression;early detection biomarkers;Evaluation;Exhibits;Fingerprint;fluorescence imaging;fluorodeoxyglucose positron emission tomography;follow-up;Functional disorder;Funding;Future;Homeostasis;Hypertrophy;Image;imaging biomarker;Impaired cognition;Impairment;improved;in vivo;Individual;Inflammation;Life;Link;Liquid substance;Longitudinal Studies;Magnetic Resonance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Metabolic Marker;Methods;mild cognitive impairment;Mitochondria;Molecular;Monitor;Motivation;myoinositol;N-acetylaspartate;Names;Nerve Degeneration;Neurocognitive;neurocognitive test;neuroinflammation;Neurons;novel;novel marker;Outcome;Pathology;Patients;Phase Transition;Plasma;Positron-Emission Tomography;predictive marker;Process;prognostication;Property;Proteins;Protocols documentation;Relaxation;Reproducibility;Research;Research Design;response;routine imaging;Scanning;Signal Transduction;Solid;Structure;tau aggregation;tau Proteins;Techniques;Testing;Time;uptake;Variant;Viscosity;Work

PROJECT_TITLE: Cellular Viscosity as a Marker for Alzheimer’s Disease Pathology: A Combined  Multiparametric MR Spectroscopy and PET Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-C(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infertility;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rare Diseases;Rehabilitation;Rural Health;Social Determinants of Health;Women's Health Research

PI_NAMEs: SU, HUI-CHUN IRENE (contact)

PROJECT_TERMS: Adolescent and Young Adult;adverse pregnancy outcome;Aftercare;anti-cancer research;arm;California;cancer care;cancer education;Cancer Patient;Cancer Science;Cancer Survivor;cancer survivorship care;care delivery;Caring;Catchment Area;Clinic;Clinical;clinical care;Communities;Community Clinical Oncology Program;community engagement;Consult;Consultations;Continuity of Patient Care;Contraceptive methods;County;Data;design;Diagnosis;Discipline of Nursing;Distress;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Evaluation;experience;Faculty;feasibility testing;Female Adolescents;Fertility;Focus Groups;Future;Geography;Health;health care delivery;health disparity;health equity;Health Insurance;health literacy;Health Personnel;Health Professional;Healthcare;high risk;Hispanic;Hispanic Populations;hybrid type 1 trial;implementation measures;implementation outcomes;implementation science;improved;Infertility;Intervention;Interview;Latina;Learning;Linguistics;low health literacy;Malignant Neoplasms;medically underserved;Menopausal Symptom;Methods;Mexico;multi-component intervention;multi-site trial;neoplasm resource;Newly Diagnosed;novel;Nursing Faculty;oncofertility;Oncology;outreach;Parents;Pathway interactions;patient navigation;Patients;Pilot Projects;pilot test;Premature Ovarian Failure;primary outcome;psychosocial outcome;Quality of Care;Quality of life;remote communities;Reporting;reproductive;Reproductive Health;Reproductive Medicine;Research;Research Personnel;Resource-limited setting;Resources;Risk;Rural;rural area;Rural Community;rural healthcare;rural Hispanic;screening;shared decision making;Social Work;Social Workers;Spanish;Spanish/English;Specialist;Structure;Survivors;survivorship;telehealth;Underserved Population;Universities;uptake;Work

PROJECT_TITLE: Pilot Project 1: Creating Bridges to Reproductive Health Care for Rural Adolescent and Young Adult Cancer Survivors


NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE This project will pioneer an innovative approach to treat highly aggressive and therapy refractory B-cell lymphomas (MCD-DLBCLs) using MALT1 targeted therapy, which interrupts key lymphomagenic pathways and at the same time has the potential to disengage anti-lymphoma T-cell responses. Using newly developed MCD-DLBCL models and fully immunocompetent syngeneic host mice in comparison with host mice lacking specific arms of the immune system, we will elucidate the contribution of T-cell responses to the anti- lymphoma activity of MALT1 inhibition. Building on this, we will establish optimal regimens of MALT1 inhibition to enhance the efficacy of immunotherapy against MCD-DLBCLs in preclinical settings and study similar effects of MALT1 inhibition in lymphoma patients enrolled in the first in human trial with a MALT1 inhibitor, thus providing the proof-of-principle to investigate its combination with immunotherapy in the clinic.

PI_NAMEs: ZAPPASODI, ROBERTA  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Acceleration;activated B cell like;Adaptive Immune System;Adult;Affect;Antigen Presentation;antitumor effect;arm;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Cell NonHodgkins Lymphoma;BCL10 gene;biological heterogeneity;Biological Markers;Cell Line;Cell Survival;Cells;chimeric antigen receptor T cells;Chronic;Classification;Clinic;Clinical;clinical development;clinical investigation;Clinical Trials;clinically relevant;Complex;Cytostatics;Data;Defect;Disease;disorder subtype;effector T cell;Engraftment;exhaust;exhaustion;first-in-human;Future;Generations;Genes;Genetic Heterogeneity;genetic signature;Genetically Engineered Mouse;Goals;Growth;Heterogeneity;Human;Immune;immune checkpoint;immune checkpoint blockade;Immune Evasion;immune resistance;Immune system;Immunity;Immunocompetent;Immunodeficient Mouse;immunogenicity;Immunotherapy;improved;In Vitro;in vivo;Infiltration;inhibitor;innovation;Interruption;large cell Diffuse non-Hodgkin's lymphoma;Large-Cell Lymphomas;lymphoid neoplasm;Lymphoma;Lymphoma cell;MAPK8 gene;Mediating;Mediator;Modeling;Molecular;mouse model;Mucosa- associated lymphoid tissue lymphoma translocation protein-1;Mus;mutant;Mutation;neoplastic cell;New Agents;non-Hodgkin's lymphoma patients;novel therapeutics;Oncogenic;Organoids;participant enrollment;Pathway interactions;Patients;Peptide Hydrolases;pharmacologic;pre-clinical;precision medicine;programmed cell death ligand 1;Proliferating;Reaction;Receptor Signaling;Refractory;Regimen;Regulatory T-Lymphocyte;Resistance;resistance mechanism;Resolution;Resources;response;Role;Sampling;scaffold;secondary lymphoid organ;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;Specimen;standard care;success;T cell response;T-Cell Activation;T-Cell Lymphoma;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;Therapeutic;therapeutic target;therapy development;therapy resistant;Time;transcription factor;tumor;Tumor Escape;Tumor Immunity;tumor progression;Validation;Wild Type Mouse

PROJECT_TITLE: Targeting MALT1 to Enhance Anti-Lymphoma Immunity and Response to Immunotherapy

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Cancer

ORG_DEPT: SURGERY

PHR: RELEVANCE There remains a great need for research to prevent and treat cancer. Surgeons-scientists are uniquely positioned to translate research findings associated with surgical diseases to the bedside and operating room. This program seeks to increase the number of surgeon-scientists that are committed to investigative excellence in academic surgical oncology.

PI_NAMEs: CHEN, HERBERT  (contact);DUDEJA, VIKAS

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Research Training;Surgical Oncology;Training Programs

PROJECT_TITLE: Surgical Oncology Research Training Program

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Achievement;Address;Adolescent and Young Adult;Advanced Malignant Neoplasm;Advisory Committees;anti-cancer research;Area;black patient;California;cancer education;cancer health disparity;Cancer health equity;Cancer Patient;Cancer Survivor;care delivery;Career Choice;Catchment Area;Clinical Trials;community advisory board;community engaged research;community partners;County;Data;Development;Disparity;disparity reduction;Documentation;education research;Evaluation;experience;Feedback;Future;Goals;graduate student;health equity;Healthcare Systems;Hispanic Women;improved;improved outcome;Inequity;innovation;Institution;Lead;Leadership;Logic;Malignant Neoplasms;Medical Students;member;Methods;Modeling;Modification;multi-component intervention;multidisciplinary;novel;novel therapeutic intervention;Outcome;Outcome Assessment;Pancreatic Ductal Adenocarcinoma;Patients;Pilot Projects;Policy Maker;Principal Investigator;programs;Provider;Reproductive Health;Research;Research Personnel;Research Project Grants;Resource Sharing;Resource-limited setting;Resources;Rural;Scholars Program;Services;System;telehealth;Testing;undergraduate student;underserved community;Universities

PROJECT_TITLE: Planning and Evaluation Core


NIH_SPENDING_CATS: Kidney Disease;Pediatric;Prevention

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PUBLIC HEALTH RELEVANCE This project is relevant to public health as kidney disease is a major cost and national health concern. By monitoring chronic kidney disease (CKD) with laboratory diagnostic measurements in pediatrics to adults, it provides an opportunity for insight into underlying disease mechanisms and their relation to cardiovascular risk, social/behavioral development, and CKD progression. To accomplish the above we will be providing laboratory services ranging from routine laboratory diagnostics, gold standard measured glomerular filtration rate testing, novel biomarker analysis, and overall support of the specimens collected for the CKiD study.

PI_NAMEs: SEEGMILLER, JESSE C (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: 14 year old;17 year old;Adolescent;Adult;Age;Age Years;Amendment;Behavior;Behavioral;Biochemistry;Biological Markers;Blood;Calibration;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Charge;Chemistry;Child;Childhood;Chromatography;Chronic Kidney Failure;Clinical;clinical practice;Clinical Trials;cohort;Collection;Complex;cost;Creatinine;Data;Development;Diagnosis;Diagnostic;Disease;Disease Progression;Diverticulitis;Dryness;emerging adult;Equation;experience;Genitourinary system;Glomerular Filtration Rate;Goals;Health;High Pressure Liquid Chromatography;improved;Individual;insight;Iohexol;Ions;Kidney;Kidney Diseases;Laboratories;Liquid Chromatography;Measurement;Measures;medical specialties;Methods;Minnesota;Modeling;Monitor;Morbidity - disease rate;mortality;Neurocognitive;novel;novel marker;Observational Study;Outcome;Patients;Pediatrics;peer;Plasma;Population;post gamma-globulins;Prevalence;Procedures;programs;Protocols documentation;Public Health;public health relevance;recruit;Reflux;renal damage;Reporting;Research;Research Personnel;Resources;Risk Factors;Routine Diagnostic Tests;sample collection;Sampling;Serum;Services;social;Social Development;Specificity;Specimen;Spottings;standard measure;tandem mass spectrometry;Testing;Trust;United States;United States National Institutes of Health;Universities;Urethra;Urine;young adult

PROJECT_TITLE: The Central Biochemistry Laboratory for the Chronic Kidney Disease in Children Cohort (CKiD)