ADMINISTERING_IC: LM

ED_INST_TYPE: LIBRARIES

IC_NAME: NATIONAL LIBRARY OF MEDICINE

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: This project will support NNLM in achieving its mission to provide U.S. researchers, health professionals, public health workforce, educators, and the public with equal access to biomedical and health information resources and data. Through its eight specific aims, the Region 6 Regional Medical Library (RML) will lead community-driven approaches to promote health literacy and address health equity through information, with a focus on underrepresented populations. The work of the RML will enable individuals to make more informed decisions about their health and lead to greater health outcomes.

PI_NAMEs: WALTON, LINDA J (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Address;Area;Awareness;Collaborations;Communication;Communities;Data;Decision Making;digital divide;Disasters;Diverse Workforce;Education;effectiveness evaluation;emergency preparedness;Emergency Situation;Evaluation;evidence base;Extramural Activities;Feedback;Health;health equity;health literacy;Health Personnel;Health Professional;Health Promotion;Health Science Library;Illinois;Impact evaluation;improved;Indiana;Individual;Information Resources;Interruption;Iowa;Lead;Libraries;Logic;Medical Libraries;member;Michigan;Midwestern United States;Minnesota;Mission;Modeling;Ohio;Outcome;outreach;Participant;programs;Public Health;recruit;Research Personnel;Services;Technology;Training;U-Series Cooperative Agreements;Underrepresented Populations;United States National Library of Medicine;Universities;Wisconsin;Work;Workforce Development;working group

PROJECT_TITLE: NNLM Region 6 Regional Medical Library


ARRA_FUNDED: N

FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PHR: None required per RFA

PROJECT_TERMS: Area;Awareness;Collaborations;Communication;Communities;Development;Disasters;Education;emergency preparedness;Emergency response;Emergency Situation;Ensure;Evaluation;Event;experience;Exposure to;Funding;Goals;Health;Health Science Library;Health Services Accessibility;Information Resources;Interruption;Iowa;Librarians;Medical Libraries;member;Mission;Modeling;Newsletter;outreach;outreach program;Participant;Productivity;programs;Protocols documentation;recruit;rural area;Services;Training;Trust;U-Series Cooperative Agreements;United States;United States National Library of Medicine;Universities;urban area;Work;working group


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Mental Illness;Pediatric;Physical Activity;Prevention;Serious Mental Illness;Sleep Research;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Suicide is the second leading cause of death among adolescents and the rates have doubled since 2000. The goal of the present study is to develop personalized risk models of adolescent suicidal ideation based on passive and objective data sources (using wearables and smartphone sensors indexing social engagement, sleep, and physical activity). Our innovative research design has the potential to identify when and how to intervene to reduce suicide risk in individual adolescents.

PI_NAMEs: BURKE, TAYLOR A (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: actigraphy;Acute;Admission activity;Adolescent;adolescent suicide;American;Behavior assessment;Behavioral;career;Cause of Death;Cellular Phone;data modeling;Data Sources;density;Detection;digital;digital delivery;digital health;Distal;dynamic system;Environment;Event;Failure;Feeling suicidal;follow-up;Foundations;Future;Goals;high-risk adolescents;Hospitalization;Hospitals;improved;indexing;Individual;Influentials;innovation;Inpatients;insight;Intervention;Interview;Knowledge;Measurement;Measures;medical schools;Mentorship;Methodology;Methods;mobile sensing;Modeling;Movement;National Institute of Mental Health;neglect;network models;Participant;Pathway Analysis;Patient Self-Report;Pattern;personalized intervention;Persons;Physical activity;Positioning Attribute;Process;programs;psychologic;recruit;reducing suicide;Reinforcing Factor;Research;Research Design;Resources;Rhode Island;Risk;Risk Assessment;Risk Behaviors;Risk Factors;Science;sensor;Sleep;social engagement;social media;Structure;suicidal adolescent;suicidal behavior;suicidal individual;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surveys;Symptoms;System;Technology;Teenagers;Text;theories;therapy development;Time;Training;Universities;unsupervised learning;wearable device;Youth

PROJECT_TITLE: Passive Assessment of Behavioral Warning Signs for Suicide Risk in Adolescents: An Idiographic Approach

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Complementary and Integrative Health;Digestive Diseases;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Parkinson's Disease

ORG_CITY: SAN BERNARDINO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CALIFORNIA STATE UNIV SAN BERNARDINO

ORG_STATE: CA

PHR: NARRATIVE Cognitive impairment is common among individuals with Parkinson’s disease and is associated with reduced quality of life and mortality. This study with determine if disruption of the gut-bacterial environment (termed dysbiosis) is associated with cognitive impairment. Findings may lead to better prognostic prediction and yield new targets for intervention.

PI_NAMEs: JONES, JACOB D (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;Age;alpha synuclein;Animal Model;Animals;Anti-Inflammatory Agents;associated symptom;Behavioral;beta diversity;Biological Markers;C-reactive protein;Chronic;Clinical;Cognition;Cognitive;cognitive function;cognitive impairment in Parkinson's;Constipation;Corpus striatum structure;cytokine;Diarrhea;Diet Modification;Dietary Administration;Dopamine;dysbiosis;Environment;executive function;fecal transplantation;Feces;Future;gastrointestinal symptom;Gastrointestinal tract structure;Genes;Genotype;Germ-Free;Goals;gut dysbiosis;gut inflammation;gut microbiome;gut microbiota;Hormones;Human;Immune response;Impaired cognition;Individual;Inflammatory;inflammatory marker;Interferon Type II;Interleukin-1 beta;Interleukin-6;Intervention;Lewy Bodies;Link;Mediating;Memory;metagenomic sequencing;Metagenomics;microbial;microbial composition;microbiome composition;microbiota;microbiota composition;Microglia;Modeling;mortality;Motor;motor symptom;Mus;Neurobehavioral Manifestations;neuroinflammation;Neuropsychological Tests;non-motor symptom;novel;Outcome;overexpression;Oxidative Stress;Parkinson Disease;Participant;Pathologic;Pathology;Pathway interactions;Patient Self-Report;Patients;performance tests;Play;Population;prebiotics;Prevotella;Probiotics;processing speed;prognostic;Quality of life;Research;Risk Factors;Role;Severities;Shotguns;Site;Sleep Disorders;Stress;Surrogate Markers;System;TNF gene;Transgenic Mice;Variant

PROJECT_TITLE: Microbiome Composition and Function Contributes to Cognitive Impairment and Neuroinflammation in Parkinson’s Disease


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Regenerative Medicine

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Inflammatory bone diseases such as periodontitis and peri-implantitis are very significant health issues that severely affect patients' quality of life and increase the risk of other systemic diseases. It is critical to understand the mechanism underlying bone remodeling in periodontitis and peri-implantitis and to develop effective strategies that prevent inflammatory bone loss and repair bone damaged. This proposal will elucidate a novel mechanism by which F-BOX Protein11 (FBXO11) regulates bone development and inflammation, and render FBXO11 signaling as a new therapeutic target to control and regenerate bone loss in periodontitis and peri-implantitis.

PI_NAMEs: CHANG, JIA  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Adult;Affect;aged;Aging;alveolar bone;Alveolar Bone Loss;Animal Model;Animals;anti-depressive agents;Apoptosis;B cell differentiation;Bacteria;Biological Process;bone;Bone Development;Bone Diseases;Bone Growth;bone loss;bone marrow mesenchymal stem cell;bone metabolism;Bone Regeneration;Bone remodeling;bone repair;Bone Resorption;Bone Transplantation;Carcinoma;Cell Culture Techniques;Cell Cycle Regulation;cell motility;Cells;Chronic;Clinical Research;Code;Data;Dental Implants;Differentiation and Growth;differentiation in vitro;Disease;Economic Burden;experimental study;F-Box Proteins;Failure;FDA approved;gene therapy;Genes;Genetic Engineering;Genomics;Growth;Health;Human;human old age (65+);Implant;In Vitro;in vivo;in vivo Model;Infection;Inflammation;Inflammatory;inflammatory bone loss;inflammatory milieu;inhibitor;innovation;Intervention;KDM1A gene;knock-down;Knock-out;Knockout Mice;Lipopolysaccharides;Mediating;melanocyte;Modeling;Molecular;mouse model;Mus;new therapeutic target;novel;Oral;Oral cavity;Osteitis;osteoblast differentiation;Osteoblasts;Osteogenesis;osteogenic;Otitis Media;overexpression;Pathway interactions;Patients;peri-implantitis;Periodontitis;Pharmaceutical Preparations;Porphyromonas gingivalis;Prevalence;prevent;Proteins;Quality of life;Regulation;Regulatory Pathway;Risk;Signal Transduction;Signaling Molecule;Site;Snails;subcutaneous;Systemic disease;therapeutic target;Tooth Loss;Tooth structure;Transgenes;Transplantation;tumor progression;validation studies;young adult

PROJECT_TITLE: Molecular control of bone development and inflammation by FBXO11

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health

PROJECT_TERMS: Address;Area;Award;Awareness;Collaborations;Communities;Community Outreach;County;Data;Decision Making;Development;digital;digital divide;digital health;Diverse Workforce;Education;Education and Outreach;effectiveness evaluation;Ensure;Evaluation;evidence base;Fostering;Funding;Funding Opportunities;Goals;Health;health equity;health literacy;Health Professional;Health Promotion;Impact evaluation;improved;Inequity;Information Resources;Information Sciences;Internet;Librarians;Libraries;Library Science;Logic;Medical Libraries;Medically Underserved Area;member;Modeling;outreach;outreach program;Population;Process;Program Development;programs;Public Health;Research Personnel;Resources;skills;Structure;Students;symposium;Technology;Training;Trust;U-Series Cooperative Agreements;Underrepresented Populations;United States National Library of Medicine;Work;Workforce Development


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: In many diseases that are difficult to treat, body tissues and whole organs become inflamed and accumulate excess scar tissue in a process call fibrosis. The mechanisms through which cells and molecules become disturbed in these diseases are complex and incompletely understood, delaying the development of new medicines. In this project, we explore previously understudied aspects of a body molecule called IL-33, which may be targeted with future therapies, and begin developing one of such innovative therapies.

PI_NAMEs: LUZINA, IRINA G. (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TITLE: Taming IL-33 to Control Inflammation and Fibrosis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Environmental Health: Transformative Research Undergraduate Experiences (E-H-TRUE) research education program at the University of Arizona (UA) seeks to recruit, educate and retain underrepresented undergraduate in environmental health sciences. The main goal of the program is to provide students with research experiences and encourage them pursuing Ph.D. or professional degrees to be active in environmental science research.

PI_NAMEs: CHEN, YIN  (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Alaska Native;American;American Indians;Arizona;Bachelor's Degree;Bioethics;career;Clinical;Collaborations;Communities;Community Outreach;cultural competence;Data;Degree program;design;Development;Doctor of Philosophy;economic disparity;Education;education planning;education research;Educational Curriculum;Educational workshop;Effectiveness;Enrollment;Environmental Health;Environmental Science;Epidemiology;ethnic minority;Evaluation;experience;Exposure to;Faculty;First Generation College Students;Fostering;Funding;Generations;Global Change;Goals;Government regulations;Grant;Hand;Health Personnel;health science research;Hispanic;Hispanic-serving Institution;Home;Hour;Immunology;improved;Industrialization;Institution;interest;Knowledge;Laboratories;Laboratory Research;Latino;Leadership;Learning;Measures;medical schools;Mentors;Minority;Mission;Modeling;National Institute of Environmental Health Sciences;notch protein;Occupations;outreach;Participant;Patient Care;peer coaching;Population;Process;programs;recruit;Research;Research Training;Review Literature;Role;Schools;Science;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Side;STEM field;Students;success;Superfund;System;Talents;Teacher Professional Development;Testing;Toxicology;Training;Training Programs;undergraduate education;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Students;Universities;Wages;Work;Writing

PROJECT_TITLE: Environmental Health Sciences: Transformational Research Undergraduate Experience (E-H-TRUE)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Cigarette smoking and nicotine dependence have been associated with delayed sleep timing, poor sleep quality and quantity, as well as sleep disordered breathing and insomnia. Our goal is to identify the contributing factors to smoking status, determine circadian characteristics of smoking behavior, and to determine the effects of acute sleep restriction on smoking withdrawal in racially diverse populations. Overall, this study will help to identify targets for smoking cessation strategies as well as lead to novel therapeutic interventions for sleep disruption and smoking abstinence, particularly among ethnic minorities.

PI_NAMEs: CROPSEY, KAREN L (contact);GAMBLE, KAREN L

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: actigraphy;Acute;addiction;Adult;Affect;Alcohol consumption;Alcohols;Beds;Black Populations;Caring;Cause of Death;Cellular Phone;Characteristics;Cigarette;cigarette smoke;cigarette smoking;circadian;Circadian Dysregulation;circadian regulation;cost estimate;craving;Data;Development;disability;Disparity;Drug usage;Ecological momentary assessment;ethnic minority;Excessive Daytime Sleepiness;Exhibits;experience;Goals;handheld equipment;health disparity populations;Heterogeneity;Hour;Intervention;Lead;Light;Link;Measures;Medical;Medical Care Costs;Melatonin;Memory;Methodology;Minority;minority disparity;Morbidity - disease rate;mortality;neural circuit;Nicotine Dependence;Nicotine Withdrawal;non-smoker;novel;novel therapeutic intervention;Obstructive Sleep Apnea;Patient Self-Report;Pattern;Periodicity;Phase;Polysomnography;poor sleep;Population;Population Heterogeneity;Prevention;Productivity;programs;Protocols documentation;Questionnaires;Race;racial difference;racial disparity;racial diversity;racial minority;racial population;relapse prediction;Reporting;Research;Rewards;Risk;secondary analysis;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;sleep quantity;sleep regulation;Sleeplessness;Smoke;Smoker;Smoking;smoking abstinence;smoking addiction;Smoking Behavior;smoking cessation;smoking intervention;smoking prevalence;Smoking Prevention;Smoking Status;Smoking treatment;socioeconomic disadvantage;Symptoms;temporal measurement;Testing;Time;Tobacco use;trend;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Circadian and sleep mechanisms among racial groups for nicotine dependence, craving, and withdrawal


NIH_SPENDING_CATS: Duchenne/ Becker Muscular Dystrophy;Lymphatic Research;Muscular Dystrophy;Pediatric;Rare Diseases

ORG_CITY: COLLEGE STATION

ORG_DEPT: PHYSIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Duchenne muscular dystrophy (DMD) is an incurable, muscle disease that affects 1 in 3500-6000 boys world- wide. Since the lymphatic system plays active roles in both the resolution and progression of inflammation, our idea is that further increasing the lymphatic vessel density in muscle tissues will augment lymph transport, and consequently, lessen inflammation and improve muscle health in DMD muscle. In this study, we will use mouse and dog models of DMD to understand how new lymphatic capillaries and the improved contractile function of lymphatics will help skeletal muscle fibers to reduce inflammation and improve muscle strength and health in DMD animals, which would potentially provide therapies to improve health in patients with DMD.

PI_NAMEs: MUTHUCHAMY, MARIAPPAN  (contact);NGHIEM, PETER PHUONG;RIMER, MENDELL

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Affect;age group;Animal Experiments;Animal Housing;Animal Model;Animal Muscular Dystrophy;Animals;Anti-Inflammatory Agents;Attenuated;Biopsy;boys;Breeding;Calcium Channel Blockers;canine model;Canis familiaris;Chronic;Clinical Trials;clinically relevant;Collection;Control Animal;Data;density;Dependovirus;Development;Disease;Distal;Duchenne muscular dystrophy;Dystrophin;Exhibits;experience;experimental study;Forelimb;Functional disorder;Gene Mutation;Genetic;Hand Strength;healing;Health;Human;Hypertension;imaging facilities;improved;in vivo;Inflammation;Inflammation Process;Inflammatory;Inflammatory Bowel Diseases;inhibitor;Limb structure;Link;Lower Extremity;Lymph;Lymphangiogenesis;Lymphatic;Lymphatic Capillaries;Lymphatic function;Lymphatic System;lymphatic vessel;Lymphedema;mdx mouse;Medical Imaging;Modeling;Molecular;mouse model;multidisciplinary;Mus;Muscle;Muscle Fibers;Muscle function;muscle strength;Muscle Weakness;Muscular Atrophy;Muscular Dystrophies;muscular dystrophy mouse model;Myopathy;next generation;novel;Nuclear;overexpression;Pathogenesis;Pathologic;Pathology;Patients;Pelvis;Pharmaceutical Preparations;Play;Psoriasis;Reactive Oxygen Species;Regulation;Reporting;Research Personnel;Resolution;response;Rheumatoid Arthritis;Role;Satellite Viruses;Scientist;Skeletal Muscle;skeletal muscle wasting;Skin;Structure;Texas;Therapeutic;tibialis anterior muscle;trend;Universities;Vascular Endothelial Growth Factor D;Weight;X Chromosome

PROJECT_TITLE: Role of Skeletal Muscle Lymphatics in Duchenne Muscular Dystrophy Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(91)S]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: WASHINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE: There is an urgent need to gain insight into HIV-1 escape from broadly neutralizing antibodies (bNAbs) to aid in more effective combination antibody strategies to be used towards HIV-1 therapy, cure and prevention. The overall objective of this proposal is to measure the ability of genetically diverse strains of HIV antibodies to escape from bNAbs and design an antibody cocktail capable of restricting escape. These findings will inform all clinical trials using bNAbs or bNAb-based molecules, and ultimately, these studies will define a rational pipeline to characterize antibody escape pathways in the future.

PI_NAMEs: LYNCH, REBECCA MARIE (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Animal Model;Antibodies;Autoimmunity;Bioinformatics;Clinical Trials;co-infection;combat;Compensation;Computing Methodologies;cost;Data;Data Set;design;env Genes;Epitopes;Evolution;fitness;Future;genetic information;Goals;gp160;HIV;HIV Antibodies;HIV-1;Human;humanized mouse;Immunotherapy;Impairment;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;Individual;insight;interdisciplinary approach;Libraries;Malignant Neoplasms;Measures;Molecular Cloning;Molecular Virology;Monoclonal Antibodies;mouse model;Mutation;neutralizing antibody;nonhuman primate;Outcome;Pathway interactions;Population;Population Genetics;pressure;Prevention;Publishing;repaired;Resistance;resistance mutation;response;Role;Sampling;Testing;theories;Therapeutic;Time;viral resistance;Virus;virus genetics;Virus Replication;Work

PROJECT_TITLE: Quantifying the fitness cost of HIV-1 resistance to broadly neutralizing antibodies

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: EL PASO

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: Findings from this research will inform educational practices that will enhance literacy and reading for linguistically-diverse students. This, in turn can enhance educational outcomes and serve as a pathway to better economical status that supports access to quality healthcare.

PI_NAMEs: SCHWARTZ, ANA I (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TITLE: Bilingual discourse comprehension: How is text integration affected by overlap in language?


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Radiation Oncology

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE We propose to develop and validate a two-part deep learning method for dose verification in patients with early-stage non-small cell lung cancer receiving definitive stereotactic body radiation therapy. We will evaluate feasibility in a prospective early-stage clinical trial, a necessary intermediate step prior to the implementation of real-time daily adaptive radiation therapy. Our long-term goal is to use real-time adaptive radiation therapy to improve tumor control and decrease radiation-related toxicities for patients receiving radiation therapy for lung cancer.

PI_NAMEs: KESARWALA, APARNA  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Air;Anatomy;artificial intelligence method;automated segmentation;Bronchial Tree;Cancer Patient;Chest;Clinic;Clinical;clinical risk;cone-beam computed tomography;convolutional neural network;cost;Data;Databases;deep learning;Dimensions;Dose;Dose Limiting;early phase clinical trial;Early treatment;effective therapy;Equipment;feasibility trial;Generations;Goals;Heart;Image;imaging Segmentation;Immobilization;improved;interest;Learning;Linear Accelerator Radiotherapy Systems;Link;loss of function;Lung;Malignant neoplasm of lung;Methodology;Methods;Modernization;Modification;Motion;Network-based;Non-Small-Cell Lung Carcinoma;novel;Organ;Outcome;participant enrollment;Patient Care;Patients;Pattern;Phase I Clinical Trials;Physicians;Positioning Attribute;primary endpoint;Primary Neoplasm;Process;prospective;quantitative imaging;Radiation;Radiation Oncology;Radiation therapy;Relative Risks;Research;Research Personnel;Resources;Risk;Role;Scanning;secondary outcome;Secondary to;simulation;standard of care;success;Supervision;System;Testing;Time;Tissues;Toxic effect;treatment duration;treatment planning;tumor;Uncertainty;Validation;Vertebral column;X-Ray Computed Tomography

PROJECT_TITLE: Early-Stage Clinical Trial of AI-Driven CBCT-Guided Adaptive Radiotherapy for Lung Cancer

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Infectious Diseases;Urologic Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative  We propose to investigate the molecular mechanism by which bacterial pathogens attach to human cells and tissues. We will focus on hair-like attachment appendages that might bind to cell surfaces in a shear-modulated manner, by changing the shape of their binding proteins.

PI_NAMEs: KLEVIT, RACHEL E;SOKURENKO, EVGENI VENIAMINOVIC (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Adhesions;Adhesives;Affinity;Amino Acids;analog;appendage;Bacteria;Bacterial Adhesins;Bacterial Adhesion;Binding;Binding Proteins;Biological Assay;Cell Adhesion;Cell surface;Cells;Characteristics;Charge;conformational conversion;conformer;Core Protein;Cryoelectron Microscopy;Crystallography;design;Dissociation;Enterobacter;Enterobacteriaceae;Escherichia coli;Escherichia coli Adhesins;Eukaryota;Family;fimbria;Fimbriae Proteins;Fimbrial Adhesins;Future;Goals;Hair;Homologous Gene;Human;human pathogen;hydrophilicity;Image;insight;Kinetics;Klebsiella pneumoniae;Knowledge;Lectin;Ligand Binding;Ligands;Mannose;mechanical force;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;molecular dynamics;Multi-Drug Resistance;Mutagenesis;mutant;Mutation;Oligosaccharides;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Physiological;Pilum;Positioning Attribute;pragmatic implementation;Property;Protein Dynamics;protein structure;Proteins;Proteus mirabilis;Receptor Cell;Rod;Salmonella;Shapes;shear stress;Side;small molecule inhibitor;Solvents;Structure;success;sugar;Surface;Testing;Tissues;tool;Uropathogenic E. coli;Vaccines;Virulence Factors;Work;X-Ray Crystallography

PROJECT_TITLE: Allosteric adhesins of enterobacterial pathogens

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

PHR: PROJECT NARRATIVE Current chlamydia prevention and control efforts have been unable to reduce chlamydia infection rates, which provides strong rationale for development of a chlamydia vaccine to prevent chlamydia and its reproductive sequelae. This project will evaluate systemic and mucosal cellular and humoral immune responses induced by promising chlamydia vaccine candidate antigens and will assess association of the immune responses with clinical correlates of protection against chlamydia in women (spontaneous clearance of chlamydia and absence of reinfection after treatment). Findings may advance chlamydia vaccine development efforts and lead to formulation of these candidate antigens into a chlamydia vaccine for a phase I study.

PI_NAMEs: GEISLER, WILLIAM M (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Acceleration;Address;Adjuvant;Aftercare;Antibodies;Antibody Response;Antigens;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Chlamydia;Chlamydia Infections;Chlamydia muridarum;Chlamydia trachomatis;chlamydia vaccine;Clinical;Clinical Treatment;Clinical Trials;Coculture Techniques;Combined Vaccines;cytokine;Data;Dendritic Cells;Detection;Development;enzyme linked immunospot assay;Enzyme-Linked Immunosorbent Assay;Formulation;Foundations;Genitalia;Goals;Human;Immune;Immune response;Immunity;Immunization;immunogenicity;Immunoglobulin G;In Vitro;Infection;infection rate;Interferon Type II;Knowledge;Laboratories;major outer membrane protein;Measures;Mediating;Membrane Proteins;Memory;memory CD4 T lymphocyte;Methods;Mononuclear;Mucosal Immune Responses;Mucous Membrane;Mus;Natural History;neutralizing antibody;novel strategies;Organism;Outcome;Participant;Peripheral Blood Mononuclear Cell;Phagocytosis;phase 1 study;Phenotype;prevent;Prevention;programs;public health priorities;reproductive;response;Sampling;screening;Secretory Immunoglobulin A;Site;Specimen;Stains;Subunit Vaccines;System;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;tissue resident memory T cell;TNF gene;Tube;Vaccine Antigen;vaccine candidate;vaccine development;vaccine formulation;Vaccines;Vagina;Woman

PROJECT_TITLE: Host Immune Responses to Chlamydia trachomatis Candidate Vaccine Antigens and their Association with Clinical Correlates of Protective Immunity in Women

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Neural circuits are constructed by synapses that connect neurons into vast networks, but how synapse formation builds a neural circuit and how such processes become impaired in neuropsychiatric disorders remains unclear. Latrophilins are postsynaptic signaling molecules that are essential for the formation of specific subsets of synapses in nearly all of the brain’s neural circuits and that may play a key role in neuropsychiatric disorders. The present project will elucidate the fundamental mechanisms by which latrophilins enable synapse formation and specify defined synaptic connections using an interdisciplinary approach in mice and in human neurons.

PI_NAMEs: SUDHOF, THOMAS C. (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Address;Adhesions;Adhesives;Affect;alpha-latrotoxin receptor;Architecture;Arrestins;Behavior;behavioral study;Binding;Binding Sites;Biological;Biological Models;biophysical analysis;Brain;Brain region;C-terminal;Cell Adhesion Molecules;Cells;Cognition;Cognitive;cognitive change;Communication;Complex;Cytoplasm;Data;entorhinal cortex;Excitatory Synapse;experimental study;extracellular;Family;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genes;Goals;GTP-Binding Proteins;Heterozygote;Hippocampus;Homo;Human;Impaired cognition;Impairment;in vivo;insight;interdisciplinary approach;interest;Investigation;Life;Ligand Binding;Ligands;Maintenance;Mediating;Molecular;Mus;Mutation;Nature;neural circuit;Neurons;neuropsychiatric disorder;Pathogenesis;Play;postnatal;postsynaptic;Process;Property;Protein Isoforms;Proteins;receptor;Role;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Site;Specific qualifier value;Specificity;Structure;Synapses;synaptic function;Synaptic Transmission;synaptogenesis;Testing;tool;translational neuroscience;Ventral Striatum

PROJECT_TITLE: Latrophilin Function in Synapse Formation


ORG_CITY: AMHERST

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: NARRATIVE Pseudomonas aeruginosa is an urgent, global, public health threat: highly resistant strains have emerged that possess a remarkable evolutionary capacity to adapt and persist in the face of therapy. In this project, our unifying focus is to develop novel combination therapies using novel non-natural nucleotides targeted at hypermutation together with existing antibiotic strategies involving β-lactam antibiotics. Taken together, our results will set the cornerstone for future testing of anti-mutators in clinical trials and provide unprecedented insight into combination therapies for Gram-negative urgent threats.

PI_NAMEs: SUTTON, MARK D.;TSUJI, BRIAN  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Animal Model;anti-microbial tolerance;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Antineoplastic Agents;arm;Attention;Aztreonam;Bacteria;Bacterial Infections;beta-Lactamase;beta-Lactams;Biochemistry;Bypass;cancer therapy;carbapenem resistance;Ceftazidime;Cell division;Cells;Chemistry;Clinical Trials;Collection;combat;combinatorial;Combined Antibiotics;Combined Modality Therapy;Communities;coping;Data;defined contribution;Development;Discipline;Disparate;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair;DNA Replication Damage;DNA-Directed DNA Polymerase;Excision;Exposure to;Fiber;Filament;Frequencies;Future;Genetic;genome integrity;Genomics;Goals;Guanine;Health;Human;In Vitro;in vivo;inhibitor;insight;Location;Maintenance;Marketing;Medical;Mismatch Repair;Mobile Genetic Elements;Modernization;mortality;Mutagenesis;Mutation;novel;novel therapeutic intervention;novel therapeutics;Nucleosides;Nucleotides;pathogen;Pathway interactions;Patients;Penicillin-Binding Proteins;Pharmaceutical Preparations;Pharmacology;Phenotype;Polymerase;pressure;prevent;Process;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Public Health;Regimen;repair function;repaired;Replication Error;Research;Resistance;resistance mechanism;resistant strain;Role;Septate;small molecule;SOS Response;standard of care;stem;System;targeted agent;Testing;therapeutic target;Time;Treatment Failure;Treatment Protocols;treatment strategy;United States

PROJECT_TITLE: Novel Combination Therapies to Combat Hypermutable Carbapenem-Resistant P. aeruginosa

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: COLUMBIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative Diseases of the female reproductive tract represent a significant problem in women's health. However, relatively little is known about the molecular mechanisms and the precise etiology and hormone regulation of endometrial progesterone resistance in female infertility. The experiments proposed in this application will utilize new genetic model systems to discover and understand these critical mechanisms.

PI_NAMEs: JEONG, JAE-WOOK  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Ablation;age group;aged;Animal Model;Biological Availability;Biological Models;biomedical imaging;Centers for Disease Control and Prevention (U.S.);cost;Couples;CXCL9 gene;Defect;Development;Diagnosis;Disease;early pregnancy loss;Endometrial;Endometrial Stromal Cell;endometriosis-related infertility;Endometrium;Epithelium;ERBB2 gene;Estrogens;Etiology;experimental study;failure Implantation;Female;Female infertility;female reproductive tract;Functional disorder;Genes;Genetic Models;Genetically Engineered Mouse;hormone regulation;Human;Imaging Techniques;Impairment;implantation;Infertility;infertility treatment;Knock-out;Mediating;Mediator;Mitogens;Molecular;molecular dynamics;Morphology;mouse model;Mus;myometrium;natural Blastocyst Implantation;overexpression;Phenotype;population based;Pregnancy;pregnancy failure;pregnant;Progesterone;Progesterone Receptors;Proliferating;Proto-Oncogenes;Regulation;reproductive;Resistance;response;Role;Signal Pathway;Signal Transduction;Spontaneous abortion;Spouses;success;Testing;Tissues;trying to conceive;uterine receptivity;Uterus;Woman;Women's Health;Work

PROJECT_TITLE: Molecular mechanisms of endometrial progesterone resistance

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_DEPT: PEDIATRICS

PHR: Physicians from underrepresented minorities and diverse backgrounds bring unique perspectives, but they remain significantly underrepresented in biomedical research. Early research exposure is a key component to increasing and sustaining the participation of medical students in research careers. This proposal features highly engaged faculty and strong institutional support to promote long-term medical student involvement in research dedicated to the prevention or mitigation of digestive and liver diseases, endocrine and metabolic diseases, obesity and nutritional disorders, or kidney and urologic diseases.

PI_NAMEs: ROGHAIR, ROBERT D (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acceleration;Achievement;Applications Grants;Appointment;Area;Award;career;cohort;college;Data;Degree program;Development;Digestive System Disorders;Endocrine;Endocrine System Diseases;Enrollment;experience;Faculty;Fellowship;Fostering;Funding;gastrointestinal;Grant;Growth;Health;Human;improved;Infrastructure;Institution;Instruction;Investigation;Iowa;Journals;Kidney Diseases;Life;Liver diseases;Medical Students;Medicine;meetings;Mentors;Metabolic;Metabolic Diseases;Methods;Mission;Modeling;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Nutrition Disorders;Nutritional;Obesity;Pathway interactions;Peer Review;Physicians;Prevention;Process;Productivity;programs;recruit;Reproducibility;Research;Residencies;responsible research conduct;Scientist;skills;Stream;student participation;student retention;Students;success;summer research;Surveys;synergism;Training;Underrepresented Populations;Urologic Diseases;Writing

PROJECT_TITLE: Iowa Medical Student Summer Research Program in trans-NIDDK Research

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunization;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative: We propose to engineer patient T cells to recognize an antigen called folate receptor-alpha, which is expressed by up to 90% of ovarian cancers, and use them to treat women with recurrent ovarian cancer, a disease which kills more than 14,000 women each year, and for which there are no effective treatment options. Here, we propose to conduct a clinical trial to test the whether these CAR T cells are safe, feasible and effective in women with recurrent ovarian cancer. We will also explore the use of a new macrophage depleting approach as a novel preparative treatment regimen to augment CAR T cell therapy in preclinical models, as a bridge to future trials.

PI_NAMEs: POWELL, DANIEL J. (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Acute Lymphocytic Leukemia;Address;Adoptive Transfer;Adult;Antibody Therapy;Antibody-drug conjugates;anticancer activity;Antigens;Antitumor Response;Area;Autologous;Biological;Bispecific Antibodies;cancer cell;Cancer Patient;CAR T cell therapy;CD19 gene;CD8-Positive T-Lymphocytes;Child;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic Lymphocytic Leukemia;Clinical;Clinical Investigator;Clinical Trials;cohort;combinatorial;Cyclophosphamide;Development;Disease;Dose;Education;effective therapy;Engineering;Enrollment;Exhibits;experience;FOLR1 gene;Foundations;Future;G-Protein-Coupled Receptors;Hematologic Neoplasms;Human;immune checkpoint;Immune response;Immunologics;immunoreaction;Immunosuppression;Immunotherapy;improved;In complete remission;in vivo;Industrialization;Infusion procedures;Injections;intraperitoneal;Intraperitoneal Injections;Investments;Lead;Lentivirus;Ligands;Macrophage;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Membrane Proteins;Modeling;Mus;next generation;novel;objective response rate;Outcome;Ovarian;overexpression;Patient Selection;Patient-Focused Outcomes;Patients;Phase;Phase I Clinical Trials;phase I trial;Phenotype;Platinum;Positioning Attribute;pre-clinical;Pre-Clinical Model;preclinical study;preconditioning;Prognosis;Recurrence;Regimen;Reproducibility;Research;Resistance;response;Safety;safety and feasibility;Schedule;Solid Neoplasm;synergism;T-Cell Proliferation;T-Lymphocyte;Technology;Testing;Therapeutic;therapeutic target;Toxic effect;Treatment Protocols;tumor;Tumor Immunity;tumor microenvironment;tumor progression;tumor xenograft;Tumor-associated macrophages;Woman;women's treatment

PROJECT_TITLE: Phase I clinical trial of adoptive transfer of autologous folate receptor-alpha redirected CAR T cells for ovarian cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ORG_DEPT: NEUROSCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: The proposed project addresses the physiological role of the astrocytic inwardly rectifying potassium channel Kir4.1 and how it modulates interneuron activity in the cerebral cortex. This channel has been implicated in a variety of neurological disorders including seizure susceptibility, epilepsy, and ALS; however, how it affects neuronal function is unknown. If successful this project will provide a better understanding of potassium homeostasis, interneuron activity, and astrocytic potassium buffering and how these contribute to pathology.

PI_NAMEs: ARMBRUSTER, MORITZ  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Action Potentials;Address;Affect;Area;Astrocytes;Automobile Driving;Biological Assay;Brain;Buffers;Cerebral cortex;Characteristics;Data;Dependence;Electrophysiology (science);Epilepsy;excitatory neuron;extracellular;fluorescence imaging;Frequencies;gamma-Aminobutyric Acid;hippocampal pyramidal neuron;Homeostasis;Hyperactivity;Image;imaging approach;In Vitro;in vitro Model;insight;Interneurons;Investigation;inward rectifier potassium channel;Measures;Mediating;Modeling;Mutation;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;neuronal excitability;Neurons;neurotransmitter release;Neurotransmitters;novel;Output;overexpression;Parvalbumins;Pathologic;Pathology;Pathway interactions;Physiological;Play;Potassium;Predisposition;presynaptic;presynaptic neurons;restraint;Role;Runaway;Seizures;Signal Transduction;Site;Sleep Wake Cycle;Somatostatin;Source;spreading depression;Synapses;synaptic function;Testing;voltage

PROJECT_TITLE: Extracellular Potassium and Astrocytic Kir4.1 Modulate Interneuron Activity in the Cerebral Cortex

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Clinical and translational research is vital to the development of new treatments for substance use disorders and for understanding the underlying neurobiological causes of these disorders. The Research Training Fellowship in Substance Abuse Program (RTFSA-P) is a well-established program within the Division of Addictions (DA) at the Yale School of Medicine Department of Psychiatry that is dedicated to training young physicians and PhD-level trainees in translational research that spans from basic science studies to clinical neuroscience research related to the field of addictions. The program trains four fellows per year and at the end of training, fellows should be well suited for independent careers in addiction research.

PI_NAMEs: KILUK, BRIAN D.;PETRAKIS, ISMENE L. (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Fellowship;Research Training;Substance abuse problem


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Calvarial skeletal stem cells (SSCs) reside in the sutural niche and contribute to calvarial bone homeostasis and healing after injury. This research project aims to determine how calvarial SSCs translocate from the sutural niche to distant regions of the calvarial bones for bone repair. The results of this research project will set the stage for future mechanistic studies to achieve the goal of developing new therapeutic approaches to regenerate and repair injured calvarial bones.

PI_NAMEs: SHIH, ANDY Y;YU, KAI  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Address;Adult;analog;Blood Vessels;bone;Bone Development;bone healing;Bone Marrow;Bone Regeneration;Bone remodeling;bone repair;Bone Tissue;Calvaria;Cartilage;cell behavior;Cell Lineage;Cells;congenital anomaly;cortical bone;craniofacial development;Defect;Development;Developmental Process;Distant;Embryonic Development;Endothelial Cells;Esthetics;Fluorescent Dyes;Future;Genetic Markers;GLI gene;Goals;healing;Histologic;Homeostasis;Iatrogenesis;Image;in vivo imaging;in vivo two-photon imaging;injured;Injury;injury and repair;intramembranous bone formation;Intravenous;Invaded;Knowledge;Label;long bone;Maintenance;Mesenchyme;Molecular;Mus;Natural regeneration;novel therapeutic intervention;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;Pericytes;Periosteum;Physiologic Ossification;Population;postnatal;postnatal development;regenerative;Regulation;Reporter;Research;Research Project Grants;Research Proposals;serial imaging;Site;skeletal stem cell;Skeleton;stem cell niche;stem cells;substantia spongiosa;Surgical sutures;Tamoxifen;Techniques;Testing;Time;Transgenic Mice;Trauma;two-photon;Vascularization;Visualization

PROJECT_TITLE: In vivo two-photon imaging of vascular invasion and stem cell translocation in calvarial bone

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Infectious Diseases;Lung

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative  The proposed research is relevant to public health because new knowledge of mechanisms by which inflammation is regulated will be acquired. This knowledge is directly applicable to understanding the broad array of diseases with dysregulated inflammation, including, including aberrant wound healing, lung and cardiovascular fibrosis, scarring, infection, sepsis, autoimmune disease and asthma. In addition, the results of these studies may identify potential targets for development of new therapies for these diseases.

PI_NAMEs: MILES, LINDSEY A (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Address;Adult;airway hyperresponsiveness;Animal Model;Anti-Inflammatory Agents;Apoptotic;Asthma;Autoimmune Diseases;Binding Proteins;Blood Coagulation Disorders;C-terminal;Cardiovascular system;CCL2 gene;cell growth regulation;Cell Physiology;Cell surface;cell type;Cells;Cessation of life;Chemotactic Factors;Cicatrix;Communication;comorbidity;Coronavirus Infections;COVID-19;Data;Development;Disease;Extracellular Matrix;Fibrosis;Funding;Goals;Homeostasis;Hospitalization;Immune;Impairment;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Integral Membrane Protein;Intervention;Investigation;Knowledge;Laboratories;Lung;Lysine;Macrophage;Maintenance;Mediator;Modeling;monocyte;Mononuclear;mouse model;Mus;neutrophil;new therapeutic target;Normal tissue morphology;novel;novel coronavirus;novel therapeutics;Ovalbumin;overexpression;Pathogenesis;Pathologic;Pathologic Processes;Patients;Peritonitis;Phagocytosis;Phenotype;Physiological Processes;Plasmin;Plasminogen;plasminogen receptor;Play;Pleurisy;Population;Proteolysis;Proteomics;Public Health;recruit;Regulation;Research;Resolution;respiratory;Role;Sepsis;Severity of illness;Signal Transduction;single-cell RNA sequencing;Site;Syndrome;System;Testing;Tissues;Up-Regulation;wound healing

PROJECT_TITLE: Regulation of cellular functions by the plasminogen receptor, Plg-RKT

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE For people who have lost the ability to move due to movement disorders, including paralysis and ALS, intracor- tical brain-machine interfaces (BMIs) aim to restore movement and communication by directly decoding neural activity from motor regions of the brain. We propose to accelerate and democratize BMI research by building a computational simulator, implemented entirely in software, that enables researchers around the world to design and optimize BMI decoder algorithms. We expect this tool will reduce BMI evaluation time from months to min- utes, and by being widely available and open source to all, considerably increase the intracortical BMI research community.

PI_NAMEs: KAO, JONATHAN CHAU-YAN (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Acceleration;Algorithms;Area;arm;Artificial Intelligence;Behavior;Brain;brain control;brain machine interface;Brain region;Clinical;Clinical Trials;Communication;Communities;Computer software;Data;deep learning;deep reinforcement learning;Democracy;design;Development;Dimensions;Emerging Technologies;Equation;Evaluation;experimental study;Feedback;Freedom;Future;Goals;Human;human model;human-in-the-loop;improved;innovation;kinematics;Learning;Macaca;Modeling;Motor;Motor Activity;Motor Cortex;Movement;Movement Disorders;neural;Neural Network Simulation;Neurosciences;neurosurgery;nonhuman primate;novel;open source;Paralysed;Participant;Performance;Persons;Policies;Population;Prosthesis;Psychological reinforcement;Publishing;recurrent neural network;Reporting;Research;Research Personnel;response;Robotics;Signal Transduction;simulation;Software Tools;System;Techniques;Technology;TensorFlow;Testing;Time;tool;Training;Translating;Work

PROJECT_TITLE: An Open Source Simulator for Multi Degree-Of-Freedom Brain-Machine Interfaces

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pain Research;Pediatric;Rare Diseases

PHR: Voltage-gated sodium and calcium channels initiate electrical signals and synaptic transmission in neurons, and they are impaired in inherited epilepsy, migraine, chronic pain, and periodic paralysis. We will determine the three-dimensional structures of the key functional elements of sodium and calcium channels at the atomic level. Learning and memory depend on modification of the strength of communication between nerve cells at synapses, a process called synaptic plasticity. We will analyze the molecular and cellular mechanism of short- term synaptic plasticity, which is important for encoding and transmitting information in neurons. Dravet Syndrome (DS) is a devastating childhood neuropsychiatric disorder caused by de novo, heterozygous loss-of- function mutations in brain type-I voltage-gated Na channel Nav1.1, which we are studying in a novel mouse genetic model. Overall, our work will define the fundamental mechanisms of sodium and calcium channel function at the atomic level; provide new understanding of the roles of these ion channels in synaptic plasticity, learning, and memory; and give key insights into the pathophysiology and novel approaches to therapy of DS.

PI_NAMEs: SCOTT, JOHN D (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Action Potentials;Aging;Ataxia;autistic;Brain;Calcium;Calcium Channel;Calmodulin;Cessation of life;Characteristics;Childhood;chronic pain;Chronic pain syndrome;Circadian Rhythm Sleep Disorders;Cognitive deficits;Combined Modality Therapy;Communication;Complex;Cre-LoxP;Disease;dravet syndrome;Elements;Epilepsy;Erythromelalgia;excitatory neuron;experimental study;Failure;Functional disorder;Genetic Models;Genetic study;Hippocampus;Impairment;in vivo;Inherited;insight;Interneurons;Ion Channel;Ions;Learning;loss of function mutation;Loss of Heterozygosity;Memory;Methods;Migraine;Modification;Molecular;molecular drug target;mouse genetics;mouse model;Mus;Mutation;neural circuit;Neurodegenerative Disorders;Neuronal Plasticity;Neurons;neuropsychiatric disorder;neurotransmitter release;next generation;novel;novel strategies;P-Q type voltage-dependent calcium channel;Paroxysmal extreme pain disorder;periodic paralysis;Physiological;premature;presynaptic;Process;Property;Proteins;Regulation;Resolution;Role;SCN1A protein;Seizures;sensor;Signal Transduction;Signaling Protein;Site;Sodium;Sodium Channel;Status Epilepticus;Structure;sudden unexpected death in epilepsy;Synapses;Synaptic plasticity;Synaptic Transmission;three dimensional structure;Transfection;transmission process;voltage;Work;X-Ray Crystallography

PROJECT_TITLE: Sodium and Calcium Channels: Structure, Function, Neuroplasticity, and Disease


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Infertility affects 1 in 6 couples worldwide, and male factors contribute to approximately half of the cases. In recent years, genetic disorders emerge as one of the leading causes of male infertility, accounting for at least 15% of male infertility cases. Thus, a high-throughput functional genomics method to systematically interrogate genetic networks underpinning male fertility would be beneficial for the diagnosis and treatment of male infertility.

PI_NAMEs: CHEN, HAIQI  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Accounting;Address;Adopted;Affect;Bar Codes;behavior influence;Cell Culture Techniques;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;computational pipelines;Coupled;Couples;Coupling;CRISPR screen;CRISPR/Cas technology;Cultured Cells;Data;Data Set;Defect;design;Diagnosis;Emerging Technologies;Equipment and supply inventories;Exclusion;experimental study;extracellular;Fertility;Foundations;functional genomics;Gene Expression Profiling;gene function;Gene Targeting;Genes;Genetic;Genetic Diseases;Genetic Transcription;Genomic approach;genomic data;genomic tools;Genomics;Guide RNA;Human;Image;Image Analysis;improved;In Situ;in situ sequencing;In Vitro;in vivo;Infertility;innovation;interest;knock-down;Knockout Mice;Label;Lentivirus;male;male fertility;Male Infertility;Mediating;Messenger RNA;Methods;Modeling;Mus;next generation;Organ;Pathologic;Phenotype;Production;Protocols documentation;Reporter;Reproductive Biology;Research Personnel;Resolution;Resources;RNA Sequences;Sampling;Seminiferous tubule structure;sertoli cell;single-cell RNA sequencing;Solid;Somatic Cell;sperm cell;Spermatogenesis;spermatogenic epithelium structure;stem cells;Testicular Tissue;Testis;Time;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomic profiling

PROJECT_TITLE: Spatially Resolved CRISPR Genomics for Dissecting Testicular Gene Functions at Scale


NIH_SPENDING_CATS: Back Pain;Bioengineering;Chronic Pain;Neurosciences;Pain Research

ORG_CITY: LINCOLN

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE Low back pain will affect the majority of the population at some point in their lifetime, and many of these patients’ pain may be caused by nerve growth, inflammation, and altered mechanical loading. Despite this knowledge, current treatments do not target these features, because their relative contribution to the pain is unknown. Our work seeks to use a novel rodent model of chronic low back pain to investigate the role of nerve presence, inflammation, and mechanical stimulation on pain generation.

PI_NAMEs: WACHS, REBECCA ANN (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Action Potentials;Affect;afferent nerve;Age;Animal Model;animal old age;Animals;antagonist;Anti-Inflammatory Agents;Behavioral;Binding;cartilaginous;Cell secretion;Cells;Chronic;Chronic low back pain;Complex;cytokine;Data;Development;Diffusion;disability;discogenic pain;Disease Progression;efficacy testing;Environment;Exhibits;Foundations;Generations;Growth;Human;Immunology;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Injury;innovation;Intervertebral disc structure;intervertebral disk degeneration;Intractable Pain;Ion Channel;juvenile animal;Knowledge;Low Back Pain;mechanical load;Mechanical Stimulation;Mechanics;Mechanoreceptors;Modeling;Musculoskeletal Pain;Nerve;Nerve Fibers;Nerve Growth Factors;Neurosciences;neurosurgery;Nociceptors;novel;novel strategies;Nutrient;Outcome;Pain;pain model;pain patient;pain sensation;Patients;Peptide Hydrolases;Peripheral;permissiveness;Phenotype;Population;Prevalence;prevent;Price;Rattus;receptor;Resolution;Rodent Model;Role;Stimulus;Stress;targeted treatment;Testing;United States;Work

PROJECT_TITLE: Decoupling Mechanical and Inflammatory Stimuli in Discogenic Low Back Pain

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: HOUSTON

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PUBLIC HEALTH RELEVANCE STATEMENT: Cleft palate is a common congenital birth defect with a complex etiology of contributions by both genetic and environmental factors. While increasing number of studies suggest a link between cellular metabolic aberrations and cleft palate, it remains largely unknown how cholesterol metabolism affects palate formation. The knowledge gained from this study will lead to a new approach for the diagnosis and prevention of cleft palate.

PI_NAMEs: IWATA, JUNICHI ;ZHAO, ZHONGMING  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: 7-dehydrocholesterol;7-dehydrocholesterol reductase;Affect;Cell membrane;Cell Proliferation;Cells;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;Cilia;Cleft Palate;Clinical;comparison control;Complex;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial development;Deformity;Dehydrocholesterols;desaturase;Development;Diagnosis;Diet;DNA Sequence Alteration;Embryo;enhanced green fluorescent protein;Environmental Risk Factor;Erinaceidae;Etiology;Exhibits;experimental study;Foundations;Gel;Gene Expression;Gene Expression Regulation;Genes;Genetic;Human;Impairment;In Vitro;in vivo;Infant;Inhibition of Cell Proliferation;inhibitor;innovation;Knowledge;Label;lathosterol;Lead;Limb structure;Link;Live Birth;Lovastatin;malformation;Mediating;Membrane;Mesenchymal;Metabolic;Metabolism;Micrognathism;MicroRNAs;Modification;Morphogenesis;Movement;Mus;mutant;Mutant Strains Mice;Mutation;Nose;novel strategies;overexpression;Oxidoreductase;Palate;palatogenesis;Pathogenesis;Patients;Penetrance;pharmacologic;Phenocopy;Phenotype;Physiological;Play;Post-Transcriptional Regulation;Post-Translational Protein Processing;posttranscriptional;Pregnancy;Prevalence;Prevention;Process;Production;protein expression;Proteins;Proteomics;Ptosis;public health relevance;Quantitative Reverse Transcriptase PCR;rab11 protein;Rab8 protein;receptor;Regulation;Risk Factors;Role;Severities;SHH gene;Smith-Lemli-Opitz Syndrome;SMO gene;smoothened signaling pathway;sonic hedgehog receptor;Sterols;Structure;Syndrome;Testing;Tooth structure;transcriptome sequencing;Untranslated RNA;Up-Regulation;Vesicle;Work

PROJECT_TITLE: Role of cellular metabolism in palate morphogenesis


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative This competitive renewal application requests continued NIMH funding for the long-standing, successful University of California, San Diego (UCSD) Fellowship in Biological Psychiatry and Neuroscience. The Fellowship is designed for provide education, research training, and career opportunities for 7 post-doctoral fellows with a particular emphasis on candidates that are focused on using biological tools to understand pathophysiology and brain processes of psychiatric illness and develop potential treatments for these disorders. The overall goal is to train fellows from diverse backgrounds and research disciplines to acquire and extend skills necessary for the conceptualization, planning, conduct, analysis and publication of research in biological psychiatry and neuroscience with the ultimate goal to become independent and funded researchers, thereby addressing the shortage of clinical researchers who can translate advances in science to treatments for psychiatric disorders.

PI_NAMEs: SHIH, PEI-AN (BETTY)  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Uterine Cancer;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE – RELEVANCE TO PUBLIC HEALTH Natural killer (NK) cells are vital components of the human innate immune system that seek out and destroy malignant cells as they arise. However, in cancer patients, their tumor cells have escaped NK cell immune surveillance and targeted killing, through various mechanisms including suppressed NK cell development. The studies outlined in this proposal will advance our basic understanding of human innate immunity and will lead to improved strategies to prevent and treat cancer.

PI_NAMEs: FREUD, AHARON G (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;angiogenesis;Award;Biological Assay;Blood;Bone Marrow;cancer cell;Cancer Etiology;cancer immunotherapy;Cancer Model;Cancer Patient;CD34 gene;Cell Differentiation process;Cell Lineage;Cell Physiology;Cell Separation;Cells;Clinical;clinically relevant;Coculture Techniques;Complement;cytotoxic;Data;design;Development;Developmental Cell Biology;developmental plasticity;Developmental Process;Effector Cell;Endometrial;Endometrial Carcinoma;experimental study;Fetal Development;fibrosarcoma;Fostering;Funding;Future;Genetic Transcription;Goals;Growth;Head and Neck Squamous Cell Carcinoma;Hematopoietic stem cells;Human;human tissue;Immune;Immune system;Immune Targeting;Immunity;Immunologic Surveillance;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Innate Immune System;Institution;Invaded;Knowledge;Light;lymph nodes;Lymphoid Cell;Lymphoid Tissue;Malignant - descriptor;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Measurement;Mediating;Melanoma;Methodology;Methods;Modeling;Molecular;mouse model;Mus;Natural Immunity;Natural Killer Cells;neoplastic cell;novel;Outcome;Pathway interactions;Peripheral;permissiveness;Phenotype;Physiological;Physiological Processes;Placenta;Play;precursor cell;Pregnancy;prevent;Process;Production;prognostic;programs;Property;Public Health;Publishing;Regulation;Reporting;Role;Scientist;Series;Shapes;Signal Transduction;stem;System;T-Lymphocyte;Testing;Therapeutic;therapeutic target;therapy design;Tissues;Tonsil;tumor;Tumor Cell Invasion;tumor growth;Tumor Immunity;Tumor Promotion;Tumor-Derived;tumorigenic;United States;Uterus;Women's mortality;Work

PROJECT_TITLE: Elucidation of Human Natural Killer Cell Development

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ORG_CITY: PROVIDENCE

ORG_NAME: OCEAN STATE RESEARCH INSTITUTE, INC.

ORG_STATE: RI

PHR: PROJECT NARRATIVE: As people get older, they lose the ability to grow new blood vessels to help with healing particularly as cholesterol builds up in the blood vessels throughout the body. Our blood cells have the ability to activate the growth of new blood vessels, but the pathways involved and the impact of aging on this ability are not fully understood. This grant seeks to understand the age-acquired changes in certain genes that might influence the signals required for new blood vessel growth. This study will lead to new medicines that can improve blood vessel growth where needed for more rapid healing in older patients.

PI_NAMEs: MORRISON, ALAN ROSS (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: 3' Untranslated Regions;Acute;adhesion receptor;Age;age effect;age related;age-related disease;aged;Aging;aging related;angiogenesis;Angioplasty;Atherosclerosis;Binding;Binding Sites;Biogenesis;Blood Cells;Blood flow;Blood Vessels;Bypass;chemokine receptor;Cholesterol;Chronic;Clinical;CpG Islands;cytokine;Data;demethylation;Diabetes Mellitus;Disease;DNA;DNA Methylation;Dose;femoral artery;Genes;Grant;Growth;Half-Life;healing;Homeostasis;Impairment;improved;Infiltration;Inflammatory;inhibitor;Injury;Integrins;Interleukin-1 beta;Ischemia;Lead;Lesion;Ligation;limb ischemia;Macrophage;Mechanics;Mediating;Medicine;Messenger RNA;Methylation;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;mRNA Instability;mRNA Stability;Mus;Muscle;Myelogenous;new growth;novel;old mice;older patient;Operative Surgical Procedures;Outcome;Pathway interactions;Perception;Peripheral arterial disease;Persons;Phenotype;Play;posttranscriptional;promoter;Protein Isoforms;Proteins;Recovery;response to injury;revascularization;Role;Signal Pathway;Signal Transduction;Site;Source;synergism;Therapeutic;therapy development;Tissue Preservation;Tissues;Transcript;Transcription Coactivator;Transfection;translational potential;Translations;treatment strategy;Untranslated RNA;Vascular Diseases;Vascular Endothelial Growth Factors;VEGFA gene

PROJECT_TITLE: Combining Targeted Demethylation with Noncoding RNA-mediated mRNA Stabilization as a Strategy for Therapeutic Arteriogenesis in the Aged

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biodefense and Related Countermeasures;Cancer;Clinical Research;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Social Determinants of Health;Substance Misuse;Tuberculosis

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The Caribbean, Central and South America network for HIV Epidemiology (CCASAnet) seeks to articulate contemporary research questions that are important to the dynamics of the HIV epidemic and other infectious diseases within CCASAnet consortium countries and globally. The proposed research will increase the understanding of the HIV care continuum, HIV in key populations, and HIV-related disease outcomes in the Caribbean and Latin America, and will support training of early-stage investigators, collaborations with public health agencies, and participation in global projects of the International epidemiology Databases to Evaluate AIDS (IeDEA).

PI_NAMEs: CAHN, PEDRO ENRIQUE;CASTILHO, JESSICA L (contact);DUDA, STEPHANY NORAH

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Address;Adolescent;analytical method;Argentina;Articulation;Behavioral;biomedical informatics;Biometry;Brazil;care delivery;Caribbean region;Caring;Central America;Chile;Clinic;Clinical;clinical application;clinical care;Clinical Data;clinical practice;Clinical Research;clinical research site;Clinical Sciences;co-infection;cohort;Collaborations;Communicable Diseases;Complex;Continuity of Patient Care;Country;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Coordinating Center;data framework;data harmonization;data management;data quality;Data Science;Data Set;data sharing;Data Sources;data tools;Databases;Diabetes Mellitus;Diagnostic Procedure;Disease;Disease Outcome;Education;Epidemic;epidemiologic data;Epidemiology;epidemiology study;experience;follow-up;Funding;Goals;Growth;Haiti;Health;health determinants;health disparity;Health Policy;Health Sciences;Healthcare Systems;HIV;HIV therapy;Honduras;improved;Incubated;Individual;Inequity;Informatics;Information Sciences;Infrastructure;Injecting drug user;innovation;insight;Institution;International;Latin America;Leadership;Life Expectancy;Link;member;men who have sex with men;Mentors;Mentorship;Methodology;Methods;Mexico;Migrant;mortality;novel;novel strategies;Observational Study;older adult;Older Population;Outcome;Patient-Focused Outcomes;Patients;Persons;Peru;Policies;Population;population health;Population Policies;Pregnant Women;preservation;Prevention;Productivity;programs;prospective;Prospective cohort;psychosocial;Public Health;quality assurance;Registries;Reporting;Research;Research Personnel;Resource Informatics;Retrospective cohort;Science;Site;skills;social health determinants;South America;Statistical Data Interpretation;synthetic data;Training Programs;Training Support;transcriptomics;transgender;transgender women;Translating;Translational Research;Treatment outcome;treatment program;Tuberculosis;tuberculosis treatment;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: Caribbean, Central, and South America network for HIV Epidemiology (CCASAnet)


NIH_SPENDING_CATS: Mental Health;Neurosciences;Pediatric

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The human amygdala contains a population of late-maturing neurons that delay their growth until childhood and adolescence when they develop into mature excitatory neurons; however, little is known about their underlying biology. The goal of this proposal is to uncover the developmental trajectories, synaptic connectivity and diversity of late-maturing amygdala neurons from their genesis to functional integration in both humans and mice. This work is fundamental to understanding how abnormal development of these neurons impacts human neurodevelopmental disorders, many of which manifest during adolescence and are characterized by altered trajectories of amygdala development and plasticity.

PI_NAMEs: SORRELLS, SHAWN  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Acute;Adolescence;Adolescent;Adult;Age;Amygdaloid structure;Anatomy;Animal Model;autism spectrum disorder;Behavior;Behavioral;biocytin;Biology;Biophysics;Birth;Brain;Cell Nucleus;Cells;Characteristics;Childhood;Cognitive;Confocal Microscopy;Data;Data Set;Destinations;Development;Electron Microscopy;Electrophysiology (science);Electroporation;Embryo;Emotional;emotional behavior;excitatory neuron;Functional disorder;Future;Goals;Growth;Human;in utero;Label;Major Depressive Disorder;Maps;Measures;Microscopy;migration;Molecular;Morphology;Mus;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;neuron development;Neurons;neuropsychiatry;novel;novel marker;patch clamp;Pathologic;Pathway interactions;Population;Population Heterogeneity;postnatal;progenitor;Property;Reporter;Role;single nucleus RNA-sequencing;single-cell RNA sequencing;Slice;social;stem cell population;Synapses;Testing;Time;timeline;transcriptomics;Work

PROJECT_TITLE: Identity of late-maturing amygdala neurons in humans and mice

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Maternal Health;Nutrition;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Effective treatments of disordered fetal growth during complications of pregnancy are lacking. This is due to limitations in our understand of the regulation of fetal growth. This project will demonstrate new roles for the hormones glucagon and placental lactogen in the regulation of fetal growth and the mechanisms by which they exert this regulation so that we can make new advances in the treatment of disordered fetal growth.

PI_NAMEs: ROZANCE, PAUL JOSEPH (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Acidosis;Amino Acids;Arteries;Blood;Blood flow;Cells;Circulation;Data;Decidua Basalis;Diabetes Mellitus;Disease Management;effective therapy;Endothelium;Ensure;Event;experimental study;falls;fetal;Fetal Diseases;Fetal Growth;Fetal Proteins;Fetal Sheep;Fetal Weight;Fetus;fetus hypoxia;Glucagon;Glucose;Goals;Growth;Growth Factor;Histologic;Hormonal;Hormones;Human;Hypoxia;In Situ;in utero;In Vitro;Infusion procedures;inhibitor;Insulin;Insulin-Like Growth Factor I;Investigation;Knowledge;lentiviral-mediated;Link;maternal obesity;Mediating;Metabolic;Metabolism;Mothers;Myometrial;novel;Nutrient;nutrient metabolism;Nutritional;Oxygen;Physiological;Placenta;Placental Insufficiency;Placental Lactogen;Placentation;Plasma;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnant sheep;preservation;prevent;Production;Publications;Regulation;restoration;RNA Interference;Role;Sheep;Signal Transduction;Techniques;Testing;trophoblast;uptake;Uterus;Vasodilator Agents

PROJECT_TITLE: Fetal glucagon links fetal metabolism with uterine blood flow and placental nutrient transfer by inhibiting placental lactogen secretion

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative (public health relevance): BBB breakdown has recently been associated with various neurological disorders including Stroke, Alzheimer's Disease, Parkinson's Disease and Multiple Sclerosis, with neurodegeneration and neuroinflammation as hallmarks of these CNS disorders. Conversely, an intact BBB also poses a major obstacle for drug delivery to the CNS, and has resulted in few therapeutic agents that can transiently cross the BBB to treat neurological disorders, psychiatric illnesses and brain tumors. Therefore, understanding the molecular mechanisms governing BBB formation and function is critical for achieving therapeutic breakthroughs and this proposal will provide new tools to identify key regulators of the BBB, fundamentally advance our understanding of the BBB, and promote discovery of novel therapies to manipulate the BBB for treating neurologic conditions.

PI_NAMEs: GU, CHENGHUA  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Alzheimer's Disease;Astrocytes;Biochemical;Biological Models;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier crossing;blood-brain barrier function;blood-brain barrier permeabilization;brain endothelial cell;Brain Neoplasms;Candidate Disease Gene;Cell Line;Cells;Cellular biology;Central Nervous System;Central Nervous System Diseases;Cerebral endothelium;Cerebrovascular system;Chemicals;Controlled Environment;Disease;Drug Delivery Systems;Endocytic Vesicle;Endothelial Cells;Endothelium;Ensure;Environment;experimental study;Goals;Image;Imaging Device;Mental disorders;Molecular;mouse genetics;Multiple Sclerosis;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neurologic;Neurology;novel therapeutics;Parkinson Disease;pathogen;Pathologic;Pathway interactions;Pericytes;Physiological;Positioning Attribute;public health relevance;Regulation;seal;Signal Transduction;Stroke;Synaptic Transmission;Therapeutic;Therapeutic Agents;Tight Junctions;tool;Toxin;transcriptome;transcytosis;Translating;vesicle transport;Work

PROJECT_TITLE: Molecular Mechanisms of the Blood Brain Barrier Function and Regulation


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Neurosciences;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: EUGENE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: 8. Project Narrative Cigarette smoking is among the leading causes of preventable death in the United States because smoking increases risk for lung cancer and various diseases. Though U.S. smoking rates have declined, a substantial percentage of adults, particularly those living in poverty who have repeatedly tried and failed to quit, still smoke and therefore could benefit from novel interventions for cessation that operate through different mechanisms than those of traditional treatments. This study will use neuroimaging to uncover the mechanisms of action of a promising strategy for affect regulation and smoking cessation and also build profiles of individuals for whom this strategy does and does not work, thereby providing tangible and practical information that public health professionals and clinicians can use to inform personalized treatments for cigarette smoking cessation.

PI_NAMEs: BERKMAN, ELLIOT TODD (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Abstinence;Adult;Affect;Affective;arm;Behavior;Cancer Control;Cigarette;cigarette craving;Cigarette Smoker;cigarette smoking;cognitive process;cognitive reappraisal;cost;craving;Data;Decision Making;Disease;Down-Regulation;efficacy trial;Event;experience;experimental study;fighting;Fire - disasters;Functional Magnetic Resonance Imaging;Future;Goals;Health behavior;Health Professional;Health Promotion;Individual;Individual Differences;Informal Social Control;insight;Intervention;Knowledge;Lateral;lens;Light;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Medial;Motivation;Multivariate Analysis;neural;neuroimaging;neuromechanism;Neurophysiology - biologic function;novel;Participant;Pathway interactions;Pattern;Personality Traits;personalized medicine;personalized strategies;Persons;Poverty;preventable death;Process;Provider;Psychology;Public Health;Regulation;Reporting;Research;response;Risk;Sample Size;Sampling;Scanning;Science;Smoke;Smoker;Smoking;smoking cessation;Stimulus;System;Techniques;Testing;Theoretical model;theories;Time;tobacco control;tool;Training;treatment as usual;treatment response;Triage;United States;Up-Regulation;Work

PROJECT_TITLE: Construal level as a novel pathway for affect regulation and cancer control

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Tuberous Sclerosis

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: The development of a functional nervous system requires precise guidance of axons and dendrites to their target locations and establishment of proper synaptic connections. This proposal is focused on understanding how the tuberous sclerosis complex (TSC) regulates the cytoskeleton to control growth and guidance of developing neurons. By developing methods to compare neurons derived from normal and patient-derived induced pluripotent stem cells, we hope to identify sites for therapeutic intervention.

PI_NAMEs: GOMEZ, TIMOTHY M (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: 3-Dimensional;Address;Affect;Animal Model;autism spectrum disorder;autosome;Axon;axon growth;axon guidance;axonal pathfinding;Binding;Biological Assay;Biological Models;Brain imaging;cell behavior;Cell Line;Cell membrane;Cells;Cognitive deficits;Complex;cortical tubers;Cues;Cytoskeleton;Data;Defect;Dendrites;desensitization;Development;Disease;Drug Screening;druggable target;Engineering;Epilepsy;Etiology;experimental study;Family;FRAP1 gene;gain of function;gene correction;Genetic Engineering;Genomics;Goals;Growth;Growth Cones;Growth Factor;Guanosine Triphosphate Phosphohydrolases;Heterozygote;Human;human induced pluripotent stem cells;imaging study;In Vitro;induced pluripotent stem cell;Intracellular Membranes;Light;Location;loss of function;Lysosomes;Measures;Mediating;Mediator;Metabolic;Methods;Modeling;Molecular;mutant;Mutation;Nervous System;neural network;Neurites;Neurodevelopmental Disorder;Neuroglia;neuron development;Neuronal Differentiation;neuronal growth;Neurons;novel;overexpression;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phosphorylation;Process;Prosencephalon;Protein Biosynthesis;protein complex;Regulation;Research;response;rho;rho GTP-Binding Proteins;Role;Seizures;Series;Signal Pathway;Signal Transduction;Site;spheroids;subcellular targeting;Symptoms;Synapses;Testing;Therapeutic;Therapeutic Intervention;Time;TSC1 gene;TSC2 gene;Tuberous Sclerosis;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Mechanisms of mTOR-independent axon growth and guidance defects in TSC2 mutant human neurons

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine

ORG_CITY: NEW YORK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative:  Treatments for mental health disorders are largely inadequate, in part because the practice of precision psy- chiatry faces extensive diagnostic heterogeneity, substantial between-patient variation in biological and clinical disease manifestation, and mismatch between diagnostic categorization and the underlying pathophysiology. This research proposes novel machine learning and statistical inference methods to address emerging challenges in precision psychiatry by discovering powerful and reliable individualized treatment strategies that address hetero- geneity, factor in a patient's clinical, psychosocial, and biological markers, and integrate evidence from multi-domain data sources and multiple studies to increase generalizability and reproducibility.

PI_NAMEs: WANG, YUANJIA  (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Accounting;Address;Advocate;Attention;Behavior;behavior test;Behavior Therapy;Behavioral;behavioral phenotyping;Biological;Biological Markers;Biology;Brain;Categories;Characteristics;Chronic;Classification;Clinical;Clinical Trials;Clinical Trials Database;cognitive control;Collaborations;comorbidity;Complex;Confidence Intervals;Data;data archive;data integration;data modalities;Data Set;Data Sources;Decision Making;denoising;design;Diagnostic;Dimensions;disability;disability-adjusted life years;Disease;effective therapy;emotion regulation;Evaluation;Face;Functional disorder;Future;generative models;Goals;Heterogeneity;improved;individual patient;individualized medicine;innovation;Learning;Machine Learning;machine learning method;Major Depressive Disorder;Maps;Measures;mental disorder diagnosis;Mental disorders;mental health center;Methods;multimodal data;National Institute of Mental Health;neuroimaging;neurophysiology;Neuropsychological Tests;novel;optimal treatments;Outcome;patient population;patient variability;Patient-Focused Outcomes;Patients;personalized medicine;pharmacologic;Phase;Psychiatry;psychosocial;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;Reproducibility;Research;Research Domain Criteria;Research Personnel;response;secondary outcome;Strategic Planning;Symptoms;tool;Training;transfer learning;treatment optimization;Treatment outcome;treatment response;treatment strategy;trend;Variant;Work

PROJECT_TITLE: Machine Learning Methods for Optimizing Individualized Treatment Strategies for Precision Psychiatry

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Neurosciences;Postural Orthostatic Tachycardia Syndrome

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative Postural tachycardia syndrome is a common and disabling disorder that can significantly interfere with the quality of life of affected subjects. We have discovered an antibody-mediated autoimmune reaction that can cause orthostatic symptoms and make it difficult for treatment. This project is directed toward elucidating an autoimmune mechanism of this debilitating disorder and to develop a safe, effective and non-invasive treatment option.

PI_NAMEs: YU, XICHUN  (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Acetylcholine;Adrenergic Agents;Adrenergic Receptor;Affect;Age;Animal Model;Animals;Antibodies;Antibody Suppression;Autoantibodies;Autoimmune;Autoimmune Process;Autoimmunity;Autonomic Dysfunction;Autonomic nervous system disorders;Basic Science;Biological;Biological Assay;Blood Vessels;Cardiac;Cardiac Myocytes;Cardiovascular system;Cells;Characteristics;cholinergic;Clinical Research;clinically significant;cohort;Data;Disabling;Disease;effective therapy;Etiology;expectation;Foundations;Functional disorder;Funding;gastrointestinal;gastrointestinal symptom;Gastroparesis;Goals;Heart Rate;human disease;Immunize;Immunologic Stimulation;immunoregulation;improved;In Vitro;in vivo;Inflammation;Inflammatory Response;inhibiting antibody;Knowledge;Ligands;Mediating;Modality;Modeling;Molecular;motility disorder;Muscarinic Acetylcholine Receptor;Muscarinics;Muscle;Neurotransmitters;novel therapeutics;Orthostatic tachycardia;Oryctolagus cuniculus;Parasympathetic Nervous System;Pathogenesis;Pathogenicity;Patients;Phenotype;Play;positive allosteric modulator;Postural Orthostatic Tachycardia Syndrome;Posture;Prevalence;Process;Production;Publishing;Quality of life;Reaction;receptor;reduce symptoms;Regulation;response;Role;Serum;Severities;sex;Signal Transduction;Stomach;Subgroup;Symptoms;Tachycardia;Testing;Therapeutic;Therapeutic Intervention;Tragus;transcutaneous stimulation;vagus nerve stimulation;Vagus nerve structure;Withdrawal;Work

PROJECT_TITLE: Autoimmune Basis for Postural Tachycardia Syndrome

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: DENTISTRY

PHR: Project Narrative  Our studies have established that loss of function mutations in the Wnt inhibitor Secreted Frizzled Receptor Protein 4 (SFRP4) are the cause of Pyle’s disease, a rare skeletal disease presenting with limb deformities characterized by gene valgum, marked cortical thinning and fragility fractures. We hypothesize that Sfrp4 expressed in a discreet pool of periosteal progenitors in the long bone and calvarium influences periosteal stem/progenitor cell activities and contributes to their bone regenerative potential. Insights gained here will be translatable to human diseases associated with bone fragility, and in the development of potential strategies for regeneration of bone defects.

PI_NAMEs: GORI, FRANCESCA  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Address;Adult;Affect;Biology;bone;bone fragility;bone healing;Bone Regeneration;bone repair;Bone Surface;Calvaria;cathepsin K;Cells;Characteristics;Clinic;Clinical;clinically significant;Collaborations;cortical bone;Defect;Deformity;Development;fragility fracture;Genes;Goals;Growth;Homeostasis;Human;human disease;Impairment;in vivo;Individual;inhibitor;Injury;injury and repair;insight;Killer Cells;Label;Lead;Limb structure;long bone;loss of function mutation;Mediating;Metaphyseal dysplasia Pyle type;Modeling;Molecular;mouse model;Mus;novel;novel sequencing technology;Online Mendelian Inheritance In Man;Osteoblasts;Osteogenesis;paracrine;Parathyroid Hormone Receptor;Patients;Periosteal Cell;Periosteum;Pharmaceutical Preparations;Phenotype;Physiological;Play;Population;Porosity;Process;progenitor;PTH gene;radiological imaging;receptor;regeneration potential;regenerative;Regenerative capacity;Regulation;repair model;response;response to injury;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Site;skeletal;skeletal disorder;Skeleton;Source;stem cell function;stem cells;Surface;Surgical sutures;Testing;Therapeutic;Therapeutic Intervention;Thick;Thinness;WNT Signaling Pathway

PROJECT_TITLE: Biology of cortical bone of long bones and calvarium: Role of Sfrp4 in periosteal bone formation


PHR: Metastatic progressive differentiated thyroid cancer is an incurable disease. We have identified a new metastasis suppression signaling pathway in thyroid cancer and other solid tumors mediated by loss of RCAN 1.4 and activation of the transcription factor NFE2L3. Our preliminary data suggest that this pathway regulates the development of a tumor-promoting immune environment; the proposed experiments will determine the mechanism by which activation of this pathway occurs and how it promotes cancer progression with an emphasis on future therapeutic targets.

PI_NAMEs: RINGEL, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Ablation;Binding;Biological Response Modifiers;Calcineurin;Cancer Cell Growth;Cancer Etiology;Cancer Model;Data;Development;Disease;Disseminated Malignant Neoplasm;Distant;Distant Metastasis;DNA Sequence Alteration;Environment;epigenetic regulation;experimental study;Future;Gatekeeping;Gene Expression;Genetic Engineering;Genetically Engineered Mouse;Genomics;Growth;Human;Human Cell Line;human tissue;IL8 gene;Immune;immune activation;immune cell infiltrate;Immune checkpoint inhibitor;In Vitro;in vivo;Invaded;Link;Malignant neoplasm of thyroid;Malignant Neoplasms;Mediating;Metastasis Suppression;Microsatellite Instability;Modeling;mortality;mouse model;mRNA Expression;Mus;Neoplasm Metastasis;novel;Oncogenic;overexpression;Papillary thyroid carcinoma;Pathway interactions;Patients;PD-1/PD-L1;permissiveness;Phenotype;Play;Process;Prognosis;promoter;protein expression;Proteins;PTEN gene;Regulation;Reporting;Role;Signal Pathway;Solid Neoplasm;Testing;therapeutic target;Thyroid Gland;Tissues;transcription factor;Transcriptional Activation;tumor;tumor progression;Tumor Promotion;tumorigenesis;tumorigenic;Xenograft procedure

PROJECT_TITLE: RCAN 1.4 metastasis suppressor in thyroid cancer

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE A major obstacle to rational HIV-1 vaccine design is the lack of an outbred primate animal model where the induction of broadly neutralizing antibodies (bNAbs) can be achieved in a consistent and reproducible manner and the molecular events leading to bNAb elicitation deciphered. This application proposes a novel “reverse vaccinology” strategy to overcome this roadblock leading to new immunogen designs and a pivotal proof-of-concept preclinical immunogenicity and protection trial in rhesus macaques. This trial will test the ability of a germline-targeted Q23.17 SOSIP Env prime, followed by lineage-designed Q23.17 SOSIP Env trimer boosts, to elicit bNAbs that protect monkeys from a heterologous tier 2 virus challenge.

PI_NAMEs: SHAW, GEORGE M (contact)

PROGRAM_OFFICER_NAME: CHAKRABARTI, BIMAL KUMAR

PROJECT_TERMS: Acceleration;Affinity;Amino Acid Substitution;Animal Model;Animals;Antibodies;Antibody Response;Antibody-mediated protection;Antigens;Apical;Autologous;B-Lymphocytes;Binding;Binding Sites;Biological;Chemicals;Chronic;Clinical Trials;Data;design;Development;Engineering;Epitopes;Event;Exhibits;Frequencies;Germ Lines;Grant;HIV-1;HIV-1 vaccine;Human;Immunogenetics;immunogenicity;Immunologics;innovation;insertion/deletion mutation;Knock-in Mouse;Laboratories;Macaca mulatta;Mature B-Lymphocyte;Modeling;Molecular;Monkeys;Mutagenesis;Mutation;nanoparticle delivery;neutralizing antibody;novel;Pathway interactions;Pattern;Peptides;Polysaccharides;pre-clinical;Prevalence;Primates;Regimen;Reproducibility;response;Reverse engineering;Rhesus;Science;Scientific Advances and Accomplishments;simian human immunodeficiency virus;Structure;Testing;Time;Translating;transmission process;Vaccination;Vaccine Design;Vaccine Research;vaccine trial;Vaccines;vaccinology;Variant;Viral;Virus

PROJECT_TITLE: HIV-1 Q23.17 Env: Engineering a novel immunogen to elicit broadly neutralizing antibodies

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Genetics;Infertility;Lymphatic Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Abnormal implantation and placental development are a major underlying cause of reproductive failure, including early pregnancy loss and spontaneous abortion. Babies born to these pregnancies or pregnancies with a diseased placenta are at a greater risk for life-long cardiovascular, metabolic and immune health problems. Therefore, developing a better understanding of the genes and proteins that govern normal implantation and placental development is critical and may ultimately lead to new clinical diagnostic tools and therapeutic approaches for the amelioration of infertility and complications of pregnancy.

PI_NAMEs: CARON, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: adrenomedullin;adrenomedullin receptor;Affect;angiogenesis;Animal Model;ARNT gene;Basic Science;bench to bedside;Biological Assay;Biological Markers;Biological Process;cardioprotection;Cardiovascular system;Cell Physiology;Cells;Cellular biology;cellular targeting;cigarette smoke;cigarette smoking;Clinic;Clinical;clinical diagnostics;Communication;CXCR;Cytoskeletal Modeling;Data;Defect;diagnostic biomarker;diagnostic tool;dosage;early pregnancy loss;Edema;Embryo Transfer;Embryonic Development;Environmental Exposure;Environmental Risk Factor;Epithelial Cells;exposure to cigarette smoke;Failure;fertility improvement;fetal;Fetal Growth Retardation;Fetal health;G-Protein-Coupled Receptors;Gene Expression;Genes;Genetic;Genetically Engineered Mouse;Gestational Diabetes;Goals;Grant;Growth;healthy pregnancy;Heart;Human;Hydrops Fetalis;Hypoxia;Image;immune health;implantation;In Vitro;in vivo;Infertility;innovative technologies;interest;Knowledge;Laboratories;Lactoferrin;loss of function mutation;Lymphatic;lymphatic development;Lymphatic Endothelial Cells;Maps;Maternal Health;Maternal-Fetal Exchange;Metabolic;mimicry;mouse model;Mus;Myocardial Infarction;Natural Immunity;Natural Killer Cells;novel;Organoids;Pathway interactions;peptide hormone;Peptide Signal Sequences;Peptides;pharmacologic;Phenotype;Physiological;Placenta;Placenta Diseases;Placentation;Plasma;Positioning Attribute;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Outcome;Process;Prognostic Marker;Progress Reports;protective effect;Proteins;receptor;Receptor Signaling;Reporter;reproductive;Reproductive Medicine;reproductive outcome;reproductive success;RiboTag;Risk;Role;Septic Shock;Signal Transduction;spatiotemporal;Spiral Artery of the Endometrium;Spontaneous abortion;Stress;Structure;subfertility;Swelling;Testing;Therapeutic;therapeutic target;Tissues;trafficking;Transcriptional Activation;Uterus;Work

PROJECT_TITLE: Adrenomedullin Signaling at the Maternal-Fetal Interface


NIH_SPENDING_CATS: Genetics

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_STATE: TX

PHR: PROJECT NARRATIVE A number of human diseases are caused by defects in the enzymes that cleave RNA. All eukaryotes have several of these genes, but what RNAs they cleave and how this causes disease is poorly understood. This study aims to increase understanding of the function of these enzymes, which will eventually provide information that could be used to treat such diseases.

PI_NAMEs: VAN HOOF, AMBRO  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Cytoplasm;Defect;Disease;endonuclease;Enzymes;Eukaryota;Event;Exonuclease;Exoribonucleases;Gene Expression;Genes;Health;Hereditary Disease;Human;human disease;Life;Mediating;Messenger RNA;mRNA Transcript Degradation;Mutation;Post-Transcriptional Regulation;posttranscriptional;Process;programs;Ribonucleases;RNA;RNA Processing;Role;targeted nucleases;Untranslated RNA

PROJECT_TITLE: RNAse functions in post-transcriptional gene regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]