ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Clinical Research;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Mental Health;Natural Products;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Cannabis use during pregnancy has increased substantially, in conjunction with legalization and decreases in the percentage of the population who believe cannabis use is harmful. Cannabis passes through the placenta and binds to cannabinoid receptors and can potentially alter prenatal brain development. In this prospective study, we will monitor cannabis use in pregnant women throughout their second and third trimester and investigate infant outcomes using brain imaging and behavioral measures that our prior work has shown to be sensitive for detecting early manifestations of neurodevelopmental disorders.

PI_NAMEs: DAGER, STEPHEN R;KLEINHANS, NATALIA M (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: adverse outcome;Affect;Age;Age Months;Alcohols;Amygdaloid structure;Animal Experimentation;Animals;Anti-emetics;Anxiety;ATOD;Attention;autism spectrum disorder;Behavior;behavior measurement;Behavioral;behavioral outcome;Binding;Biological Assay;Birth;Birth Weight;Brain;brain dysfunction;Brain imaging;Brain region;Cannabidiol;cannabinoid receptor;Cannabinoids;Cannabis;Cell Adhesion Molecules;Cerebellum;Complementary and alternative medicine;Conceptions;Conscious;Consumption;COVID-19 pandemic;Data;density;design;Development;Diffusion Magnetic Resonance Imaging;Disease;Dopamine D2 Receptor;Dose;drug of abuse;Early Diagnosis;Educational Status;Endocannabinoids;Enrollment;Evaluation;Exclusion Criteria;Exhibits;experience;Female;fetal marijuana exposure;First Pregnancy Trimester;follow up assessment;Frequencies;frontal lobe;Functional Magnetic Resonance Imaging;Goals;Growth;Head circumference;Health;Health Benefit;Human;Illicit Drugs;imaging study;in utero;indexing;infancy;Infant;infant outcome;Influentials;innovation;Label;Legal;Legal Status;Length;Magnetic Resonance Imaging;male;marijuana legalization;marijuana use;marijuana use in pregnancy;marijuana user;maternal marijuana use;Measures;Medicine;Memory;Modernization;Monitor;Mothers;motor behavior;Multimodal Imaging;myelination;Nausea and Vomiting;Neonatal;neural;neurobehavior;neurobehavioral;neurodevelopment;Neurodevelopmental Disorder;Neuropsychology;Newborn Infant;Odors;Outcome;Outcomes Research;Pacific Northwest;pain reduction;Participant;Pathway interactions;Patient Self-Report;Perception;Persons;Pharmacologic Substance;Placenta;polysubstance use;Population;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Product Labeling;programs;Property;prospective;Prospective Studies;Protocols documentation;Psychotropic Drugs;receptor density;Recreation;recruit;Regulation;Reporting;Research;response;reward processing;Risk;Second Pregnancy Trimester;Sex Differences;Signal Transduction;Sleep;Stimulus;Structure;symptom management;System;Testing;Tetrahydrocannabinol;Third Pregnancy Trimester;Time;Tobacco;Update;Urine;Visit;Washington;white matter;Woman;women's outcomes;Work

PROJECT_TITLE: Brain and behavior correlates of prenatal cannabis exposure

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Urologic Diseases

ORG_CITY: AMHERST

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: About 84,000 patients are expected to be diagnosed with bladder cancer this year and about 70-80% of the patients will have non-muscle invasive bladder cancer (NMIBC), which is considered the golden time for cure of bladder cancer. Although intravesical treatments have been used following transurethral surgery, recurrence and progression to the advanced stage still remain critical problems. This proposed integrative project will provide new effective treatment strategy and prodrugs for treating NMIBC with a great potential for rapid clinical translation.

PI_NAMEs: YOU, YOUNGJAE  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;Aminolevulinate;Animals;anti-cancer;Antineoplastic Agents;Bacillus Calmette-Guerin Therapy;Bladder;Bladder Tissue;Brain;Canada;cancer cell;Cancer Model;Cancer Patient;cancer therapy;cell killing;Cells;Cessation of life;chemotherapy;Clinical;clinical practice;clinical translation;Combined Modality Therapy;Cystoscopy;Diagnosis;Diffusion;Disease;docetaxel;Dose;drug action;drug clearance;Drug Delivery Systems;Drug Design;Drug Exposure;Drug Kinetics;Drug usage;effective therapy;efficacy evaluation;Excision;FDA approved;Fluorescence;Functional disorder;gemcitabine;Goals;high risk;Human;Immune;implementation barriers;improved;In complete remission;In Vitro;in vivo Model;indexing;innovation;Interruption;intravesical;Intravesical Administration;Light;Malignant neoplasm of cervix uteri;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of ovary;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Medical Care Costs;Micrometastasis;Mitochondria;Mitomycin C;Modeling;multidisciplinary;Nature;non-muscle invasive bladder cancer;Normal tissue morphology;novel;novel strategies;Operative Surgical Procedures;Optics;optimal treatments;Organ;Oryctolagus cuniculus;Outcome;Patients;pembrolizumab;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Physiological;Physiology;Process;Prodrugs;Property;Protocols documentation;protoporphyrin IX;PUVA Photochemotherapy;Rattus;Recurrence;Regimen;Research;side effect;Singlet Oxygen;stem;System;Technology;three dimensional cell culture;three-dimensional modeling;Time;tool;Transurethral Resection;Treatment Efficacy;treatment optimization;Treatment Protocols;treatment strategy;tumor;uptake;Urethra;Urine;urologic;Urologist;Work

PROJECT_TITLE: Singlet Oxygen-cleavable Prodrugs for Treating Non-Muscle Invasive Bladder Cancers

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Infectious Diseases;Machine Learning and Artificial Intelligence;Malaria;Networking and Information Technology R&D (NITRD);Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The global malaria burden is demanding new therapeutics and a change in drug discovery paradigm to more time- and cost-efficient approaches. We propose herein the use of machine learning methodologies to discover novel dual-stage antimalarials lacking cross-resistance with existing therapies. The deliverables will be new computational models for hit discovery and validated hits which will be evolved to early lead molecules.

PI_NAMEs: DERBYSHIRE, EMILY R;FREUNDLICH, JOEL STEPHEN (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Address;analog;Animal Model;Anti-malarials;aqueous;Artemisinins;Biological;Biological Assay;Biology;Blood;Blood Cells;candidate identification;Cells;Cessation of life;Chemical Structure;Chloroquine;Chloroquine resistance;Competence;Computer Models;cost;cost efficient;cytotoxicity;Data;design;Development;Disease;disorder control;Diversity Library;drug development;drug discovery;Drug Kinetics;Drug resistance;Effectiveness;efficacy evaluation;Erythrocytes;Evaluation;Evolution;experience;Future;Goals;Grant;Growth;Hepatocyte;HepG2;heuristics;high throughput screening;human disease;In Vitro;in vivo;Infection;inhibitor;innovation;Invaded;Lead;Libraries;Life;Life Cycle Stages;Liver;Liver Microsomes;Machine Learning;machine learning method;machine learning model;machine learning prediction;Malaria;malaria infection;Malignant Neoplasms;Measures;meetings;Modeling;Molecular;Mus;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Organic Synthesis;Parasite resistance;Parasites;pathogen;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Physicians;Plasmodium;Plasmodium falciparum;prevent;Probability;Productivity;Property;prophylactic;Prophylactic treatment;Publications;Pyrimethamine;random forest;Reporting;Research Personnel;Resistance;Resources;Risk;screening;skills;small molecule;Solubility;statistics;Sulfadoxine;Symptoms;Technology;Testing;Therapeutic;Time;tool;Training;transmission process;Triage;Validation

PROJECT_TITLE: Novel Dual-Stage Antimalarials: Machine learning prediction, validation and evolution

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Quantifying and preventing privacy leakages in data will enable increased use of omics and clinical data, thus permitting better statistical power for genotype–phenotype relationship inferences. The ability to accomplish this goal requires the development of efficient statistical, information theoretical, and privacy-preserving tools. The proposed research combines novel algorithmic advances with traditional bioinformatics methods for processing and combining genomics, transcriptomics, and clinical data in a privacy-enhancing manner.

PI_NAMEs: GURSOY, GAMZE  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Adopted;Algorithms;Bioinformatics;Biological;Clinical;Clinical Data;Computer software;Conflict (Psychology);Data;data access;Data Analyses;data modalities;data privacy;Data Security;Democracy;Development;Disease;Epigenetic Process;Extravasation;Future;Genetic;Genomics;Genotype;Goals;Human;human data;Individual;Medical;Methods;Mining;Molecular;novel;Participant;patient privacy;Patients;Phenotype;phenotypic data;Population;prevent;Privacy;privacy preservation;privacy protection;Privatization;Research;Research Personnel;theories;tool;transcriptomics;Trust

PROJECT_TITLE: Tools to Address the Challenges of Preserving Privacy in Sharing and Analysis of Biomedical Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)R]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative This project proposes to investigate the epigenetic dependency of PAX3-FOXO1-driven rhabdomyosarcoma on histone demethylases KDM4, test the translational potential of a novel KDM4 inhibitor and assess the mechanism of action of the KDM4 inhibitor.

PI_NAMEs: CHEN, XIANG ;YANG, JUN  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Adolescent;Adverse effects;Alveolar Rhabdomyosarcoma;ATAC-seq;Biochemical;Biological Testing;Biology;cancer cell;cell motility;Cell Proliferation;cell transformation;Cells;chemotherapy;Chemotherapy and/or radiation;Child;Childhood Soft Tissue Sarcoma;Chromatin;Chromatin Structure;Chromosomal translocation;Clinical;Combined Modality Therapy;Complementary DNA;Coupled;Data;Dependence;Disease;Disease Progression;effective therapy;Epigenetic Process;epigenomics;Ewings sarcoma;EWS-FLI1 fusion protein;experimental study;Family;FOXO1A gene;functional genomics;Fusion Oncogene Proteins;Genes;Genetic;Genetic Transcription;Genomic approach;Goals;high risk;histone demethylase;histone methyltransferase;Histones;Human;improved;In Vitro;in vivo;inhibitor;innovation;Invaded;knock-down;Knock-out;Lysine;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;member;methyl group;Methylation;migration;Modality;Modeling;Modification;Molecular;Molecular Abnormality;Molecular Conformation;mouse model;mutant;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Oncoproteins;Outcome;Output;Pathogenesis;patient derived xenograft model;Patients;PAX3 gene;PAX7 gene;pharmacologic;Play;pre-clinical;programs;protein expression;Research;Rhabdomyosarcoma;Risk;Role;single-cell RNA sequencing;small molecule;soft tissue;t(2;13)(q35;q14);Techniques;Testing;Therapeutic;Toxic effect;transcription factor;transcriptome;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;Translating;translational potential;Treatment Efficacy;tumor;tumor growth;tumorigenesis;Tumorigenicity;Validation;Variant;Xenograft Model;Xenograft procedure;young adult

PROJECT_TITLE: EXPLORE AND TARGET THE EPIGENETIC VULNERABILITY OF PAX3-FOXO1-DRIVEN RHABDOMYOSARCOMA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: HERSHEY

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Project Narrative The Opioid Epidemic constitutes a major public health crisis as rates of opioid use and overdose continue to rise in the United States. Many individuals with opioid user disorder struggle to remain abstinent, even those who have undergone treatment, necessitating development of new therapeutics. We will deepen our understanding of how opioid use changes the brain to promote relapse by identifying and manipulating activity- dependent transcriptional and epigenetic changes in an opioid self-administration mouse model, thereby informing new treatment approaches.

PI_NAMEs: FOX, MEGAN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Amygdaloid structure;Animals;Automobile Driving;Award;Behavior;Brain;Calcium;Cementation;Clustered Regularly Interspaced Short Palindromic Repeats;Data;demethylation;Development;differential expression;Disease;DNA Methylation;Drug usage;Epigenetic Process;fentanyl self-administration;Financial cost;gene network;Genes;Genetic study;Genetic Transcription;Health Care Costs;Individual;Intake;medication-assisted treatment;Methylation;Molecular;mouse model;multiple omics;neuromechanism;Neurons;new therapeutic target;novel therapeutic intervention;novel therapeutics;Nucleus Accumbens;Opioid;opioid epidemic;opioid exposure;opioid overdose;opioid use;opioid use disorder;opioid user;Pharmaceutical Preparations;Physiology;prolonged abstinence;promoter;Public Health;Recovery;Relapse;relapse prevention;Research;Resolution;Rewards;Self Administration;Substance Use Disorder;support network;Synaptic plasticity;Testing;United States;Ventral Tegmental Area

PROJECT_TITLE: Identifying multi-omic signatures of opioid use and relapse


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: A major approach for treating brain disorders non-invasively is application of a transient magnetic field to the head, a procedure called transcranial magnetic stimulation (TMS). The effects of TMS are relatively weak, however, and help only a minority of patients, likely due to unoptimized protocols for applying the stimulation. This project will use recordings of nerve cells in the brain, paired with models of brain activity, to reveal the fine- scale mechanisms of TMS and promote biologically-founded improvements to its use.

PI_NAMEs: PETERCHEV, ANGEL V;SOMMER, MARC A (contact)

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: Acute;Affect;Anatomy;Area;Axon;Basic Science;Behavioral;Biological;Biology;biophysical model;Biophysics;Brain;Brain Diseases;Brain region;Clinical;Cognitive;Computer Simulation;Corticospinal Tracts;Coupled;Custom;Data;design;Development;electric field;Electroencephalography;Electromyography;Electrophysiology (science);Elements;experimental study;Foundations;Frequencies;Functional Imaging;Functional Magnetic Resonance Imaging;Funding;Goals;Head;hippocampal pyramidal neuron;Human;human subject;imaging modality;improved;inhibitory neuron;insight;Knowledge;Macaca mulatta;magnetic field;Measurement;Measures;Mediating;Mental Depression;Mental disorders;Methodology;Methods;Migraine;Minority;Modeling;Morphologic artifacts;Motor Cortex;multi-scale modeling;Nervous System Disorder;neural;neural circuit;neural recruitment;neuronal circuitry;Neurons;neurophysiology;neuroregulation;nonhuman primate;novel;Obsessive-Compulsive Disorder;Outcome;Patients;Pattern;pharmacologic;Physiologic pulse;Physiological;Physiology;Prefrontal Cortex;Procedures;Process;Protocols documentation;rational design;Recurrence;repetitive transcranial magnetic stimulation;Research Personnel;Resistance;response;Safety;simulation;Site;Spatial Distribution;Spinal;Spinal Cord;Stimulus;Synapses;Synaptic plasticity;System;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Training;Transcranial magnetic stimulation;United States National Institutes of Health

PROJECT_TITLE: Biology and Biophysics of the Cortical Response to Transcranial Magnetic Stimulation


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative Ending the HIV epidemic requires implementing proven tools in areas with the highest need such as the Deep South. We propose to adapt and deploy three tools to promote (1) HIV testing in under-tested communities, (2) effective linkage to care, and (3) rapid start of antiretroviral therapy in order to push three counties in rural Alabama closer to meeting targets to end the HIV epidemic. We will learn from administrators, providers, and clients how to adapt and scale the combination intervention to improve HIV outcomes in other rural HIV-endemic settings like Alabama.

PI_NAMEs: MATTHEWS, LYNN T;RANA, AADIA  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Administrator;Adult;Affect;Alabama;antiretroviral therapy;Area;Attitude;Big Data;care systems;Caring;Centers for Disease Control and Prevention (U.S.);Client;Clinic;Clinical;Clinical effectiveness;Collaborations;Communities;community academic partnership;community clinic;concept mapping;Consolidated Framework for Implementation Research;County;Data;Data Set;Deep South;Diagnosis;Diagnostic;effectiveness outcome;effectiveness/implementation study;effectiveness/implementation trial;Epidemic;Evaluation;Evidence based intervention;experience;Federally Qualified Health Center;formative assessment;Funding;Future;Geography;Goals;Health;Health Service Area;Health system;HIV;HIV diagnosis;Human immunodeficiency virus test;implementation evaluation;implementation outcomes;implementation strategy;implementation trial;implementation/effectiveness;improved;Incidence;Individual;Inequity;innovation;Intervention;Interview;Learning;Link;Maintenance;Maps;meetings;Mission;Newly Diagnosed;novel;Outcome;outreach;Persons;Population;population health;Positioning Attribute;Poverty;Prevalence;prevention service;Process;programs;Provider;Public Health;Qualitative Methods;racial disparity;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Personnel;Rural;rural counties;social stigma;surveillance data;Surveys;System;Techniques;Testing;Time;tool;United States;United States Dept. of Health and Human Services;Universities;Viral;Work

PROJECT_TITLE: A type 2 hybrid effectiveness-implementation trial to evaluate a population health combination intervention to meet HIV testing, linkage, and viral suppression goals in coastal Alabama


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Understanding the genetic basis of blood cell development is key to gain insight into immune deficiency disorders and leukemias. The fruit fly, Drosophila melanogaster, is a very powerful model organism for genetic dissection of blood development and studies in this model organism have led to several important advances in humans and provided the means to fill the gap between descriptive observations and in vivo function. This work explores the mechanisms that determine the balance between maintenance of blood progenitors and blood cell differentiation, which is critical for ensuring normal immune system development and function.

PI_NAMEs: BANERJEE, UTPAL  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Address;Affect;Bar Codes;Biological;Blood;Blood Cells;Carbon Dioxide;Cell Cycle Progression;Cell Cycle Regulation;Cell Differentiation process;cell growth;Cell Proliferation;cell type;Cells;combinatorial;Complement;Complex;Coupled;Coupling;Cytoplasm;Data;Development;Disease;Dissection;Distal;Drosophila genus;Drosophila melanogaster;Ensure;Environment;Equilibrium;Event;experience;experimental study;Future;G2 Phase;gene interaction;Genetic;genetic analysis;genetic manipulation;Genetic Models;Genomics;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Heterogeneity;Homeostasis;Human;Immune system;Immunologic Deficiency Syndromes;in vivo;Individual;insight;interest;leukemia;Link;lymph nodes;Maintenance;Mammals;MAPK8 gene;Metabolic Pathway;Mitosis;model organism;Modeling;Molecular;Molecular Genetics;Morphology;Mus;Myeloid Cells;nutrition;Organ;Outcome;Pathway interactions;Play;Population;preservation;Process;progenitor;Proliferating;Property;Published Comment;Research;Role;Route;Signal Pathway;Signal Transduction;Smell Perception;spatiotemporal;stem cell proliferation;Stress;System;Systems Development;Technology;Testing;tool;transcriptome;transcriptomics;Work

PROJECT_TITLE: Genomic and Genetic Dissection of Hematopoietic Development in Drosophila

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative An emerging new discipline termed “Cancer Neuroscience” addresses functional interactions between tumors and the nervous system. We propose a training program that will enable doctorate level basic scientists to work within this new field. Our trainees will address therapeutic challenges and develop new medicines for cancers and for a variety of neurologic disease states.

PI_NAMEs: BATCHELOR, TRACY T (contact);GREENBERG, MICHAEL ELDON

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Cancer Neuroscience Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The goal of the proposed project is to better understand the molecular underpinnings and cell diversity of opioid use disorder in the human brain. This study will conduct a joint profiling of methylomics, hydroxymethylomics, 3D chromatin structure, and transcriptomics of OUD in single nuclei from human postmortem brain to identify molecular targets that may inform prevention and treatment efforts.

PI_NAMEs: MONTALVO-ORTIZ, JANITZA LIZ (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: 3-Dimensional;addiction;Amygdaloid structure;Autopsy;Brain;Brain region;Cell Nucleus;cell type;Cells;Chromatin Structure;cohort;Data Collection;Data Set;DNA;DNA Methylation;DNA methylation profiling;DNA Sequence Alteration;Environment;Epidemic;Epigenetic Process;epigenomics;Etiology;Gene Expression Regulation;Genes;Genetic Research;genetic risk factor;genetic variant;Genome;genome wide association study;genome-wide;Genomics;Goals;hospitalization rates;Human;Individual;innovation;insight;Joints;Maps;methylomics;Modification;Molecular;Molecular Target;multiple omics;novel;Nucleus Accumbens;opioid use disorder;overdose death;Peripheral;Pharmaceutical Preparations;Prefrontal Cortex;Prevention;programs;Research;Role;Sampling;Signal Transduction;Structure;Tissues;transcriptomics;United States;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Deciphering the single-nucleus genomic regulatory structure of opioid use disorder in the human brain


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Mental Health;Osteoporosis;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: PROJECT NARRATIVE Social isolation is an increasing public health problem and is associated with many negative physiological and psychological health outcomes. A handful of studies, including my own, have shown that social isolation also leads to bone loss in mice. This proposal will investigate the mechanisms by which social isolation affects bone metabolism, which may inform future clinical studies and treatment strategies in individuals suffering from social isolation.

PI_NAMEs: MOUNTAIN, REBECCA  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: 11-beta-Hydroxysteroid Dehydrogenases;Adrenergic Agents;Affect;antagonist;Anxiety;Architecture;beta-2 Adrenergic Receptors;Biological Markers;biological sex;bone;Bone Density;bone health;bone loss;Bone Marrow;bone mass;bone metabolism;Bone Resorption;Brain;Catecholamines;circulating microRNA;Clinical;Clinical Research;Clinical Treatment;coping;Corticosterone;COVID-19 pandemic;Data;Disease;epidemiology study;experience;Exposure to;Female;Femur;Fracture;fracture risk;Future;Gene Expression;Genes;Genetic;genetic approach;Glucocorticoid Receptor;Glucocorticoids;Goals;Health;Histologic;Homeostasis;Human;human old age (65+);Image;Individual;inhibitor;Knockout Mice;Loneliness;lonely individuals;Long-Term Effects;male;Measures;Mediating;Mental Depression;Mental disorders;Mental Health;Metabolic;Metabolism;Metyrapone;MicroRNAs;miRNA expression profiling;Modeling;Molecular;Morbidity - disease rate;mortality;mortality risk;mouse model;Mus;NADH dehydrogenase (ubiquinone);neural;novel;old mice;older adult;Osteogenesis;Osteoporosis;Outcome;pharmacologic;Phase;Phenotype;Physiological;Populations at Risk;Prevalence;prevent;Prevention strategy;Propranolol;Proteomics;Psyche structure;Psychosocial Stress;Public Health;receptor;receptor expression;Research;response;Risk;Rodent;Role;Serum;sex;Sex Differences;Signal Transduction;skeletal;Social isolation;Stress;stress disorder;substantia spongiosa;Sympathetic Nervous System;Testing;therapeutic target;Thick;Time;treatment strategy;Work

PROJECT_TITLE: Investigating the Impact of Social Isolation on Bone Metabolism

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Finding effective treatments for neurological disorders and strokes requires not only a fundamental knowledge of the nervous system but also the participation of a diverse workforce to enhance our overall creativity. The inclusion of underrepresented groups in the biomedical scientific workforce is critical to addressing the need for improving the health of the U.S. population and eliminating health disparities nationwide. This project will increase the number of undergraduates from underrepresented minority groups being trained as the next generation of neuroscientists.

PI_NAMEs: DE LA CRUZ, MARLENE ;MOTA-BRAVO, LUIS M (contact);WOOD, MARCELO ANDRES

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: academic preparation;Achievement;Address;Admission activity;Age;American;Anatomy;Area;Award;Behavior;Behavioral Sciences;Binding;Biological Sciences;Biomedical Research;Black Populations;California;Career Mobility;Categories;cohort;college;community college;computer program;cost;Creativeness;Data;Dedications;dementia risk;Diverse Workforce;Doctor of Philosophy;Education;effective therapy;Engineering;Environment;evidence base;experience;Faculty;Feeling;Funding;graduate school;Grant;Health;health disparity;Hispanic;Hispanic Populations;Hispanic-serving Institution;improved;innovation;Institution;Intervention;Knowledge;Laboratories;laboratory experience;Latino;Mathematics;Measurable;medical schools;Mentors;Minority;Minority Groups;minority undergraduate;Names;National Research Council;Nervous System;Nervous System Disorder;Neurobiology;Neurosciences;next generation;Outcome;Paper;Participant;Population;Principal Investigator;programs;Publications;Quantitative Reasoning;Research;Research Personnel;Research Project Grants;Research Training;responsible research conduct;role model;San Francisco;Schools;Science;Scientist;Self Efficacy;Series;skills;Social support;Societies;STEM field;Stroke;Students;symposium;Time;Training;Training Programs;undergraduate research;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;university student;Vision;Writing

PROJECT_TITLE: Broadening Research Achievement in Neurosciences (BRAiN) for a Diverse Workforce


ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: RELEVANCE TO PUBLIC HEALTH Critical treatment gaps exist for the sustained, local delivery of therapeutics, with a particularly urgent need for local anesthetics that are used to treat post-operative pain and minimize exposure to opioid medications. This work generates new biomaterial films and particles that are designed to be implanted within the body and that feature brush-like polymers extending from a surface, like blades of grass on a lawn. The approach represents a new platform to enable discoveries about how the brush-like polymer architectures impact therapeutic loading and release, as well as provide the opportunity to tune how cells interact with the materials, affording the potential to control tissue localization and immune responses toward implanted materials.

PI_NAMEs: BURKE, KELLY ANNE (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Affect;Anesthetics;Architecture;Biocompatible Materials;Biology;biomaterial interface;Brush Cell;Bupivacaine;Cardiotoxicity;Cell Communication;cell type;Cells;Collection;Connective Tissue;Data;design;Diffusion;Encapsulated;Exposure to;Fibroins;Film;Formulation;Frustration;Goals;Growth;Immune;Immune response;immunoengineering;Implant;implant material;In Vitro;in vivo;in vivo Model;Injectable;Knowledge;Laboratory Research;Length;Liquid substance;Local Anesthetics;local drug delivery;Methods;Modeling;Modification;molecular assembly/self assembly;molecular scale;Morphology;mouse model;Muscle;nanoscale;Nerve Block;Operative Surgical Procedures;particle;Phagocytosis;Pharmaceutical Preparations;pharmacokinetic model;Phase;Poaceae;Polymers;Postoperative Pain;prescription opioid;programs;Property;Proteins;Public Health;rational design;Research Project Grants;response;Science;Shapes;Silk;Site;Statistical Data Interpretation;Structure;success;Surface;surgical pain;Testing;Therapeutic;tissue culture;Tissues;tool;Variant;viscoelasticity;Work

PROJECT_TITLE: Highly Tunable Brush-Like Polymer Architectures to Control Therapeutic Delivery and Cell-Material Interactions


ADMINISTERING_IC: EY

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: Columbus

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE for P30 The purpose of The Ohio State University Vision Sciences Research Core Program (OSU-VSRCP) is to enhance the environment for NEI-funded PIs and other vision science faculty who represent five Colleges: Medicine, Optometry, Veterinary Medicine, Engineering and Arts & Sciences. Three cores are proposed based on a survey of 61 scientists: Core A-Structural and Functional Assessments, Core B-Biostatistics, Bioinformatics and Genetic Analysis, and Core C-Image Analysis and Data Science. The institutional commitment (i.e., support the Program Director includes successful recruitment of vision scientists, space for a new confocal microscope purchase for Core A, and space in the 2023 Interdisciplinary Research Facility) supports our common goal to prevent blindness, restore vision and develop cures for eye diseases.

PI_NAMEs: MOROI, SAYOKO E (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: advanced analytics;Agreement;analytical tool;Angiography;Animal Model;Architecture;Artificial Intelligence;Arts;Bioinformatics;biomedical informatics;Biometry;Blindness;Cell model;Clinical Research;clinical translation;cluster computing;Collaborations;college;Communities;computer science;Computers;Core Facility;cost;Data;Data Analyses;Data Commons;data mining;Data Science;Data Science Core;Data Set;Data Storage and Retrieval;design;Development;Electrophysiology (science);Engineering;Ensure;Environment;Equipment;equipment acquisition;Evaluation;Eye diseases;Faculty;Faculty Recruitment;flexibility;Funding;Fundus photography;Genes;Genetic;genetic analysis;genomic data;Genomics;Goals;Health Services;Health Services Research;High Performance Computing;high standard;Human;Image Analysis;image guided;image processing;implementation science;Individual;Institution;Interdisciplinary Study;Lasers;Leadership;Learning;Letters;Machine Learning;manufacture;Medical center;Medicine;meetings;Microscope;model organism;Morphology;Neurosciences;Ohio;Ophthalmology;Optometry;Outcome;Pathway Analysis;Pediatric Hospitals;Pediatrics;prevent;Procedures;programs;Protocols documentation;Psychology;recruit;Research;Research Design;research facility;Research Personnel;Research Project Grants;Resources;response;Science;Scientist;Service delivery model;Services;sight restoration;statistics;Strategic Planning;supercomputer;Surveys;synergism;System;Technical Expertise;Thinking;tonometry;Training;Universities;Variant;Veterinary Medicine;Vision;Vision research;vision science


NIH_SPENDING_CATS: Bioengineering;Data Science;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

PROJECT_TERMS: Agreement;Artificial Intelligence;Arts;Bioinformatics;biomedical informatics;Biometry;Blindness;clinical care;Clinical Research;clinical translation;Clinical Trials;cluster computing;Collaborations;college;Communication;Communities;computer science;Computer software;Core Facility;cost;Data;Data Science;Data Science Core;Data Sources;design;Doctor of Philosophy;Education;Electronic Mail;Engineering;Ensure;Equipment;equipment acquisition;expectation;Expenditure;experience;Eye diseases;Faculty;Faculty Recruitment;Feedback;Funding;Future;Genetic;genetic analysis;Goals;Grant;High Performance Computing;high standard;Human Resources;Image;Image Analysis;Individual;Institution;instrument;Leadership;Letters;Marketing;Medicine;meetings;Microscope;Neurosciences;Occupations;Ohio;operation;Ophthalmology;Optometry;Outcome;Pediatric Hospitals;Pediatrics;Policies;prevent;Productivity;programs;Protocols documentation;Psychology;Publications;Quality Control;Reporting;Research;Research Personnel;Resources;Schedule;Science;Scientist;Services;sight restoration;statistics;supercomputer;Surveys;synergism;Telephone;Universities;Update;Veterinary Medicine;Vision;Vision research;vision science;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Lung;Machine Learning and Artificial Intelligence;Prevention;Tobacco;Tobacco Smoke and Health

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative For Chronic Obstructive Pulmonary Disease (COPD, the 4th cause of death in the USA) defined by irreversible airflow, there is emerging evidence that suggests that variation in airway tree structure is common in the general population and is a major contributor to unexplained COPD risk. The proposed research is relevant to public health because understanding airway tree structure subtypes from lung CT scans would advance our knowledge of disease susceptibility and improve personalized therapies, prognosis, and identify an underlying genetic basis to COPD risk. Thus, this proposal is relevant to the part of NIH’s mission that pertains to fostering fundamental creative discoveries and innovative research strategies as a basis for ultimately protecting health.

PI_NAMEs: LAINE, ANDREW FRANCIS (contact);SMITH, BENJAMIN M.

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Air Movements;airway obstruction;Asthma;Biological;Caliber;Candidate Disease Gene;Cause of Death;Cessation of life;Chronic Obstructive Pulmonary Disease;cigarette smoking;clinically relevant;clinically significant;cohort;Complex;cost;Country;Creativeness;deep learning;Detection;detector;Development;Developmental Biology;Diagnostic tests;Dictionary;Disease Pathway;disease prognosis;Disease susceptibility;disorder risk;environmental tobacco smoke;Event;Exhibits;follow-up;Fostering;Funding;General Population;Generations;generative models;Genetic;genetic epidemiology;genome wide association study;Grant;Health protection;High Resolution Computed Tomography;high standard;Image;Impairment;improved;Individual;innovation;Intervention;Investigation;Knowledge;Label;Link;Longterm Follow-up;Lung;lung development;lung lobe;lung volume;Machine Learning;machine learning method;Manuals;Mathematics;Measures;Minority;Mission;Modeling;Morphology;Multi-Ethnic Study of Atherosclerosis;National Heart, Lung, and Blood Institute;never smoker;novel;Obstructive Lung Diseases;Occupational;Outcome Measure;Pathway interactions;personalized medicine;Phenotype;pollutant;Prognosis;prognostic significance;Public Health;Publishing;pulmonary function decline;Quality of life;Radiology Specialty;Reproducibility;Research;Resolution;respiratory;Respiratory Signs and Symptoms;Risk;Risk Factors;risk stratification;risk variant;Role;Scanning;Severities;Shapes;Smoker;Smoking;Spirometry;Standardization;Structure;supervised learning;Testing;Textbooks;Time;Tobacco;tool;Trees;United States;United States National Institutes of Health;unsupervised learning;Variant;Work;X-Ray Computed Tomography

PROJECT_TITLE: Airway Tree Subtyping on Large Cohorts of CT Images for COPD Risk

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: FISCHER, ANDY J (contact)

PROJECT_TERMS: Agreement;Angiography;Animal Model;Arts;Blindness;Cell model;Cells;Clinical Research;clinical translation;cluster computing;Collaborations;college;Communities;Complex;Consultations;cost;Data;data acquisition;Data Science;design;Educational Status;Electrophysiology (science);Eligibility Determination;Engineering;Ensure;Environment;Equipment;equipment acquisition;experience;Experimental Designs;experimental study;Eye diseases;Faculty;Faculty Recruitment;Fluorochrome;Funding;Fundus photography;Future;Goals;Grant;High Performance Computing;high standard;Image;image guided;Individual;Institution;instrument;Lasers;Leadership;Letters;manufacture;Medicine;meetings;Microscope;Mission;Neurosciences;new technology;Ohio;Ophthalmology;Optometry;Outcome;Pediatric Hospitals;Pediatrics;Preparation;prevent;programs;Proteins;Protocols documentation;Psychology;Quality Control;Research;Research Personnel;Research Project Grants;Reservations;Retina;Science;Scientist;Services;sight restoration;Specimen;structural imaging;supercomputer;Surveys;synergism;System;Technical Expertise;Testing;tonometry;Training;Universities;Veterinary Medicine;Vision;Vision research;vision science

PROJECT_TITLE: Core A. Structural and Functional Assessments (SFA)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Eye Disease and Disorders of Vision;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: GAO, XIAOYI RAYMOND (contact)

PROJECT_TERMS: advanced analytics;Applications Grants;Arts;Bioinformatics;Biological;Biometry;Blindness;Clinic;Clinical Investigator;Clinical Research;clinical translation;cluster computing;Collaborations;college;Communities;Computer software;Computers;Consultations;Copy Number Polymorphism;cost;Data;Data Analyses;data management;Data Science;Databases;design;Detection;Documentation;Engineering;Ensure;Environment;Equilibrium;Equipment;equipment acquisition;Exclusion;exome;Eye;Eye diseases;Faculty;Funding;Future;Gender Identity;gene environment interaction;Gene Frequency;Genes;Genetic;genetic analysis;genetic association;Genetic Research;Genetic study;genome sequencing;Genomics;Goals;Group Meetings;High Performance Computing;high standard;Individual;Institution;Jordan;Leadership;Letters;Manuscripts;Medicine;meetings;Methodology;Minor;Molecular Biology;Neurosciences;Ohio;Ophthalmology;Optometry;Outcome;Pathway Analysis;Pediatric Hospitals;Pediatrics;population stratification;Preparation;prevent;programs;Proteomics;Protocols documentation;Psychology;Quality Control;Regression Analysis;Research;Research Design;Research Personnel;Research Project Grants;Resources;Sample Size;Sampling;Science;Science of genetics;Scientist;Services;sight restoration;Single Nucleotide Polymorphism;single-cell RNA sequencing;skills;Statistical Data Interpretation;statistics;supercomputer;Surveys;synergism;Testing;Training;transcriptome sequencing;transcriptomics;treatment response;Universities;variant detection;Veterinary Medicine;Vision;Vision research;vision science;whole genome;Work

PROJECT_TITLE: Core B. Biostatistics, Bioinformatics and Genetic Analysis (BBGA)


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE More efficient hematopoietic progenitor cell (HPC) generation from cultured induced pluripotent stem cells (iPSCs) would support translational research and cell therapies. I used penalized regression modeling of human genetic data, and iPSC cell models, to determine that the Tropomyosin 1 gene normally constrains in vitro HPC production. In this grant, I will determine mechanisms by which Tropomyosin 1 constrains HPC development, and define other genetic mechanisms that could be manipulated to augment in vitro HPC yield.

PI_NAMEs: THOM, CHRISTOPHER STEPHEN (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Actins;Address;Advisory Committees;aging demography;Award;Biochemical;Bioinformatics;Biology;Blood;Blood Cells;Blood Platelets;blood product;Blood Transfusion;Candidate Disease Gene;candidate validation;career;causal variant;Cell Culture Techniques;Cell Line;Cell model;Cell Therapy;cell type;Cells;Cellular biology;Childhood;Chromatin;clinically relevant;Communicable Diseases;Complex;Computer Models;Core Facility;CRISPR/Cas technology;Cultured Cells;Cytoskeleton;Data;Data Science;Development;differentiation in vitro;Disease Outbreaks;Doctor of Philosophy;Endothelial Cells;Endothelium;Environment;Epigenetic Process;Erythrocytes;Fellowship;Funding;Gene Expression;Gene Modified;Generations;Genes;Genetic;genetic approach;Genetic Determinism;Genetic study;genetic testing;genome wide association study;genome-wide;genomic data;genomic locus;Goals;Grant;Healthcare Systems;Hematopoiesis;Hematopoietic;hematopoietic differentiation;hematopoietic stem cell formation;Hematopoietic stem cells;Human;Human Genetics;human induced pluripotent stem cells;human model;improved;In Vitro;induced pluripotent stem cell;induced pluripotent stem cell technology;Institution;interest;Isoantibodies;K-Series Research Career Programs;knock-down;Knock-out;Laboratories;Link;Maps;Megakaryocytes;Mentorship;Modeling;Molecular;Molecular Biology;molecular hematology;multidisciplinary;Neonatal;next generation sequencing;novel;Other Genetics;overexpression;Pathway interactions;Patients;Pediatric Hospitals;Pediatrics;Pennsylvania;perinatal medicine;Phase;Philadelphia;Physicians;precursor cell;predictive modeling;Production;programs;Quantitative Trait Loci;Reagent;Research;research and development;Research Support;Residencies;Resources;Role;Running;Scientist;Secure;Single Nucleotide Polymorphism;single-cell RNA sequencing;Site;skills;small hairpin RNA;Source;stem cell biology;Stem Cell Development;stem cells;success;Surface;System;Techniques;Therapeutic;Training;Training Programs;trait;Transfusion;transfusion medicine;Translational Research;Tropomyosin;United States National Institutes of Health;Universities;Validation;Variant;White Blood Cell Count procedure

PROJECT_TITLE: Determining genetic mechanisms that drive in vitro hematopoiesis


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Multiple Sclerosis;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Telehealth

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Our two Multiple Sclerosis (MS) Centers have been at the forefront of deploying telehealth to improve access to outpatient MS care, and, while we have demonstrated both feasibility and high satisfaction at the time of service, there are broader knowledge gaps regarding its impact on clinical outcomes and on the high costs (>$48 billion) of and access barriers to MS care. We propose a 2-year 2-Center randomized pilot trial to determine whether telehealth for MS care in newly diagnosed patients can maintain clinical outcomes, improve satisfaction, and reduce costs of care relative to in-clinic visits. We will also perform detailed qualitative analyses to understand patient and care team experiences, preferences, concerns, and satisfaction regarding telehealth care to identify facilitators and barriers to widespread implementation of telehealth.

PI_NAMEs: MCGINLEY, MARISA  (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Absenteeism at work;Academy;Address;Adherence;Adult;Affect;American;arm;Automobile Driving;California;care costs;care delivery;Caregiver Burden;Caring;central nervous system demyelinating disorder;Chronic;Clinic;Clinic Visits;Clinical;clinical care;clinical trial participant;Communities;Comprehensive Health Care;cost;cost comparison;Cost Effectiveness Analysis;COVID-19 pandemic;Data;design;Diagnosis;Digital biomarker;Direct Costs;disability;Disease;Dropout;economic impact;Emergency department visit;Enrollment;Ensure;Equity;Evaluation;experience;Face;Facilities and Administrative Costs;follow-up;General Population;Goals;Health;Health Care Costs;health care delivery;health care service utilization;health related quality of life;Health Services Accessibility;Healthcare;Home;Hospitalization;hospitalization rates;Immune;Improve Access;improved;insight;Intervention;Interview;Knowledge;Mediating;Medical;Methodology;Methods;Modality;Modeling;multidisciplinary;Multiple Sclerosis;multiple sclerosis patient;Neurologist;Neurology;Newly Diagnosed;novel;Outcome;Outpatients;Participant;Patient Outcomes Assessments;Patients;Patterns of Care;Perception;Persons;Pharmaceutical Preparations;pilot trial;Policies;Population;Positioning Attribute;preference;Procedures;Productivity;Provider;Quality of life;Quality-Adjusted Life Years;Randomized;randomized trial;randomized, clinical trials;Recommendation;Regulation;Research;Resources;Sampling;San Francisco;satisfaction;Savings;Schedule;Secure;Services;Site;Specialized Center;Standardization;Surveys;System;telehealth;telehealthcare;teleneurology;Testing;theories;Time;Travel;two-arm study;Universities;usability;Visit;Work

PROJECT_TITLE: Clinical and Economic Impact of Teleneurology vs Standard in Clinic Care for Multiple Sclerosis: A Randomized Trial

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

PI_NAMEs: DOBLE, NATHAN  (contact)

PROJECT_TERMS: Address;Architecture;artificial intelligence algorithm;Arts;Biological Sciences;Blindness;Clinical Research;clinical translation;cluster computing;Collaborations;college;Communities;computer science;Computers;Consultations;cost;Data;Data Commons;Data Engineering;data mining;data repository;Data Science;Data Science Core;Data Set;Development;electronic health data;Electronic Health Record;Engineering;Ensure;Environment;Equipment;equipment acquisition;Eye diseases;Faculty;Funding;Future;Goals;Guidelines;Health Services;Healthcare;High Performance Computing;high standard;Image;Image Analysis;image processing;implementation science;Individual;innovation;Institution;Institutional Review Boards;large datasets;Leadership;Letters;Machine Learning;Medicine;meetings;member;Methods;Modeling;Neurosciences;Ohio;Ophthalmology;Optometry;Outcome;Pediatric Hospitals;Pediatrics;prevent;programs;Protocols documentation;Psychology;Research;Research Personnel;Resources;response;Rest;Science;Scientist;Services;sight restoration;Software Engineering;supercomputer;Surveys;synergism;System;Technology;Thinking;Training;Universities;Veterinary Medicine;Vision;Vision research;vision science;Visualization;Work

PROJECT_TITLE: Core C. Image Analysis and Data Science (IADS)


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: DENVER

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF DENVER (COLORADO SEMINARY)

ORG_STATE: CO

PHR: Project Narrative  We propose to develop a novel theoretical framework using mathematical modelling, all-atom simulation and experimental data (in-vitro and in-vivo) to understand sequence-conformation-function relation in disordered proteins. Our work is of biomedical relevance due to its importance in understanding fundamental principles that biology relies on to alter conformation of Intrinsically Disordered Proteins that constitute a large fraction of human proteome and perform great many vital biological functions. Strategies learnt from the work will help design new sequences to control function of these proteins with potential for therapeutic application.

PI_NAMEs: GHOSH, KINGSHUK  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Alternative Splicing;Amino Acid Sequence;Amino Acids;Benchmarking;Biological;Biological Process;Biology;Cell Differentiation process;Cells;Charge;Chemicals;Classification;Collaborations;combinatorial;Communities;computer framework;Conserved Sequence;cost;Coupling;Data;design;Disease;disease model;DNA;environmental change;experimental study;Explosion;Face;functional gain;Goals;Grain;high throughput analysis;Homology Modeling;Hot Spot;Human;improved;In Vitro;in vivo;Inosine Diphosphate;insight;Ionic Strengths;Knowledge;Link;Liquid substance;Location;Maps;mathematical model;Measures;Membrane;Minor;Modeling;Modification;Molecular Conformation;multi-scale modeling;Mutation;novel;Organelles;Pattern;Phase;Phase Transition;Phosphorylation;Physical condensation;Physics;Polymers;Positioning Attribute;Post-Translational Protein Processing;Predisposition;Property;protein folding;protein function;Proteins;Proteome;Publishing;Radial;Regulation;Research;RNA Splicing;Role;Science;Sequence Alignment;Shapes;simulation;single-molecule FRET;Site;Source;Structure;success;Temperature;theories;Therapeutic;tool;Transcriptional Regulation;trend;Variant;Work

PROJECT_TITLE: Modeling Conformational Ensembles of the Disordered Proteins

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;HIV/AIDS;Infectious Diseases;Major Depressive Disorder;Mental Health;Mental Illness;Patient Safety;Serious Mental Illness

ORG_CITY: IBADAN

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN

PHR: Project Narrative The overall goal of this project is to provide advanced training to equip Dr Adedeji Waheed A (a physician/scientist) with skills and competencies in clinical trial, population pharmacokinetics, pharmacokinetics/pharmacodynamics modeling and pharmacogenomics. These skills will equip Dr Adedeji to establish a research career in HIV clinical pharmacology and pharmacogenomics. The burden of HIV/AIDS is of global health concern, and Nigeria has the third largest burden of the disease in the world but lacks research capacity in HIV clinical pharmacology and pharmacogenomics.

PI_NAMEs: ADEDEJI, WAHEED ADEOLA (contact)

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: ABCG2 gene;Adult;Adverse event;anti-depressive agents;Anti-Retroviral Agents;antiretroviral therapy;Area;Award;burden of illness;career;Caring;Chronic;Clinical;Clinical Pharmacology;Clinical Research;Clinical Trials;comorbidity;Competence;Consensus;Country;CYP2D6 gene;CYP3A4 gene;Cytochrome P450;Depressed mood;design;Dose;Drug Interactions;Drug Kinetics;Effectiveness;Environment;Enzymes;Epidemiology;Expenditure;experience;Failure;Fluoxetine;Genes;Genetic Polymorphism;global health;Goals;HIV;HIV Seropositivity;HIV-infected adolescents;HIV/AIDS;Income;inhibitor;inhibitor therapy;Integrase;Internal Medicine;Kinetics;Knowledge;low and middle-income countries;Major Depressive Disorder;Master of Science;Mediating;Medical;Medical Residency;medication compliance;Medicine;Membrane Transport Proteins;Mental Depression;Mental disorders;Mentors;Mentorship;Metabolism;Minor;Monitor;Morbidity - disease rate;mortality;neuropsychiatric disorder;neuropsychiatry;Nigeria;Outcome;Patients;Persons;Pharmaceutical Preparations;pharmacodynamic model;Pharmacogenomics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Physicians;Placebo Control;Plasma;Population;precision drugs;prevent;professor;programs;Psychopharmacology;Regimen;Reporting;Research;Research Personnel;Research Project Grants;Research Training;response;Safety;Scientist;Selective Serotonin Reuptake Inhibitor;Single Nucleotide Polymorphism;skills;Statistical Methods;statistics;System;systematic review;Testing;Toxic effect;Training;Training Programs;Treatment Failure;treatment optimization;Treatment outcome;UGT1A1 gene;Viral

PROJECT_TITLE: Influence of fluoxetine on the disposition kinetics of dolutegravir among people living with HIV with major depression in Nigeria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-L(57)R]


ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: NARRATIVE Overall Component This P30 Core Grant provides essential infrastructure and expertise for the investigators of the Visual Sciences Research Center at Case Western Reserve University who study major inherited and acquired blinding diseases such age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, Leber’s congenital amaurosis, Stargardt’s disease, Fuchs dystrophy, and glaucoma. Through its critical functions, this grant will continue to enhance the ability of vision researchers to decipher the mechanisms of many common blinding diseases and develop new therapies for their treatments. The grant will also facilitate collaborations among vision researchers and will help bring new investigators to vision field.

PI_NAMEs: PIKULEVA, IRINA A (contact)

PROJECT_TERMS: Acquired Blindness;Age related macular degeneration;animal resource;Anterior eyeball segment structure;Arts;Award;Basic Science;Center Core Grants;Clinical Sciences;Collaborations;college;common treatment;Contract Services;Core Grant;cost;Diabetic Retinopathy;Disease;Eligibility Determination;equipment acquisition;First Independent Research Support and Transition Awards;Fostering;Fuchs' Endothelial Dystrophy;Funding;Funding Mechanisms;Genotype;Glaucoma;Grant;Growth;Individual;Infrastructure;Inherited;innovation;Interdisciplinary Study;Laboratories;Leber's amaurosis;Medical center;medical schools;Molecular Biology;novel therapeutics;Ophthalmology;Pathologic Processes;Productivity;programs;recruit;repaired;Research;Research Personnel;Resource Sharing;Resources;Retina;Retinal Diseases;Retinitis Pigmentosa;Schools;Science;Series;Services;Stargardt's disease;symposium;United States National Institutes of Health;Universities;University Hospitals;Vision;Vision research;vision science;Wages

PROJECT_TITLE: CWRU NEI Vision Center Core Grant


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PROJECT_TERMS: Advisory Committees;Budgets;Center Core Grants;Communication;Contract Services;Core Grant;Effectiveness;Equipment;equipment acquisition;experience;Feedback;Grant;Investments;Leadership;Maintenance;medical schools;meetings;Monitor;National Eye Institute;new technology;operation;Ophthalmology;Performance;Progress Reports;repaired;Research;Research Personnel;Resources;Running;Services;Supervision;Universities;University Hospitals;Vision;vision science


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurosciences

PI_NAMEs: VON LINTIG, JOHANNES FRIEDRICH (contact)

PROJECT_TERMS: animal resource;Animals;Breeding;Center Core Grants;Collaborations;cost efficient;data management;Ensure;Equipment;experience;experimental study;Gene Modified;Generations;Genetically Modified Animals;Genotype;Human Resources;Individual;Methods;Molecular;Molecular Biology;Mus;Mutation;Phenotype;Process;Research;Research Personnel;Resources;Retina;Structure;Time;Vision;vision science;Work

PROJECT_TITLE: The Specialized Animal Resources Core


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics

PI_NAMEs: PARK, PAUL S (contact)

PROJECT_TERMS: Center Core Grants;cost;cost efficient;Equipment;experience;Genotype;Housing;Human Resources;Individual;Laboratories;Location;Methods;Molecular Biology;mouse model;Mus;Mutation;Research;Research Personnel;Resources;Running;Science;Services;Time;Training;Vision;vision science

PROJECT_TITLE: The Molecular Biology and Genotyping Core


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: SUBAUSTE, CARLOS S (contact)

PROJECT_TERMS: Biological;Cells;Center Core Grants;Consultations;Core Facility;Core Grant;cost;Data;Dissection;Ensure;Equipment;experience;Experimental Designs;experimental study;Eye;Goals;histological slides;histological specimens;histological stains;Histology;Human Resources;Hybridomas;Image;imaging software;Immunohistochemistry;Incentives;Individual;interest;Laboratory Research;mass spectrometer;Mass Spectrum Analysis;Microscope;Microscopy;Paraffin;Pathologic;Pharmacologic Substance;Pharmacological Treatment;Process;Production;Proteins;Publications;Research;Research Personnel;Resources;sample fixation;Sampling;Services;Slide;small molecule;Stains;Structure;Techniques;Technology;tissue culture;Tissues;Training;Universities;Vision;Vision research;voucher

PROJECT_TITLE: Analytical Services Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cardiovascular;Clinical Research;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Childhood cancer patients have an increased risk of developing heart failure because of chemotherapy and radiation treatments. As a result, many survivors of childhood cancer receive lifetime screening with echocardiograms (ultrasound of the heart) to monitor their long-term heart function. The proposed project would apply new computer artificial intelligence-based methods to improve the ability of echocardiograms to detect earlier heart disease in these high-risk survivors.

PI_NAMEs: BOYLE, PATRICK M;CHOW, ERIC JESSEN (contact);EDWARDS, LINDSAY ATHERTON

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: 3-Dimensional;Address;Adult;Age;Anthracycline;Architecture;Artificial Intelligence;Biomedical Engineering;Calibration;cancer imaging;Cancer Patient;Cancer Survivor;Cardiac;cardiac magnetic resonance imaging;Cardiology;Cardiomyopathies;Cardiotoxicity;Chemotherapy and/or radiation;Chest;Child;childhood cancer survivor;Clinical;cohort;Community Clinical Oncology Program;Computers;Consensus;convolutional neural network;cost;Data;Data Set;deep learning;Dependence;Detection;Development;Diagnosis;disease diagnosis;Disease Outcome;Early Diagnosis;Early Intervention;Echocardiography;efficacy evaluation;Equilibrium;Exposure to;Functional disorder;General Population;Geometry;Guidelines;Heart;Heart Diseases;Heart failure;heart function;high risk;high risk population;Image;image archival system;imaging biomarker;imaging modality;improved;improved outcome;Individual;insight;Interdisciplinary Study;interest;International;Interobserver Variability;Ionizing radiation;Left;Left Ventricular Dysfunction;Left Ventricular Ejection Fraction;Long-Term Survivors;Machine Learning;Malignant Childhood Neoplasm;Measurement;Measures;Medical Imaging;Medicine;Methods;Monitor;Morbidity - disease rate;National Clinical Trials Network;Network-based;Oncology;Onset of illness;outcome prediction;Patients;Pattern;Pediatric Oncology Group;premature;Process;programs;Radiation therapy;Recommendation;Research;Risk;screening;Sedation procedure;Shortening Fraction;standard of care;Standardization;Survivors;Testing;Therapeutic;Time;Training;Treatment-Related Cancer;two-dimensional;ultrasound;unstructured data;Ventricular

PROJECT_TITLE: Machine Learning-Based Identification of Cardiomyopathy Risk in Childhood Cancer Survivors


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE A promise of precision medicine is that individual genome sequence data will enable the determination of disease risk and effective treatments, however unravelling contributions of genetic variation to disease remains one of the greatest challenges in genomics. By combining DNA editing with single-cell transcriptomics, we will experimentally decipher regulatory networks for a whole human chromosome and engineer hundreds of genetic variants to uncover their gene regulatory effects. This data will be used to train machine learning models to predict regulatory interactions throughout the genome and across cell types.

PI_NAMEs: STEINMETZ, LARS M (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 3-Dimensional;Alleles;ATAC-seq;base editing;Binding;Biological Models;causal variant;Cell Line;Cell model;cell type;Cells;Chromatin;Chromosome 11;Chromosomes;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;Computer Models;cost;Coupling;CRISPR/Cas technology;Data;Data Set;Disease;disease phenotype;disorder risk;DNA;DNA sequencing;DNase I hypersensitive sites sequencing;effective therapy;Elements;empowerment;Engineered Gene;Engineering;Enhancers;functional genomics;Future;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;genetic element;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome editing;genome sequencing;genome wide association study;genome-wide;genomic data;genomic tools;Genomics;Hi-C;Human;Human Chromosomes;Human Engineering;improved;Individual;Knowledge;Link;Location;Logic;machine learning model;Measures;Mediating;Methods;Modeling;Molecular;novel;novel strategies;Nucleic Acid Regulatory Sequences;Organism;Outcome;Performance;Phenotype;precision medicine;predictive modeling;Primary Cell Cultures;Process;promoter;Proteins;Reading;Regulatory Element;Relaxation;Reporting;Resolution;screening;single cell genomics;Technology;Testing;Time;Tissues;tool;Training;trait;transcription factor;transcriptome sequencing;transcriptomics;Untranslated RNA;Variant;variant of unknown significance

PROJECT_TITLE: Function-based exploration of genetic variation at genome-scale

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE – OVERALL The UK CTSA program hub is uniquely positioned in the National CTSA Consortium to foster novel technologies, team science, clinical trial start-up and cutting-edge translational research across the lifespan. Our UK CTSA hub has a significant presence on the national stage, and our focus on the Central Appalachian community, a rural region with many of the highest priorities (i.e., cardiovascular, neuroscience, cancer, obesity/diabetes) of health disparities in the nation and an epicenter for the opioid and substance abuse epidemic, distinguishes our mission and activities. The programs in this proposal will ultimately elevate the health and quality of life for people of this region and provide a national model for rural, underserved populations. Project Narrative Page 277

PI_NAMEs: HARTMANN, KATHERINE E;KERN, PHILIP A (contact)

PROGRAM_OFFICER_NAME: DOYLE, JAMIE MIHOKO

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Agriculture;Appalachian Region;Award;Cardiovascular system;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Research;clinical research site;Clinical Sciences;Clinical Trials;Collaborations;collaborative environment;college;Communities;community engagement;community research;Complement;Computer software;COVID-19 pandemic;Dedications;Development;Diabetes Mellitus;Discipline;Distress;diversity and inclusion;Economics;Engineering;Environment;Epidemic;Fostering;Funding;Future;Generations;Grant;Growth;Health;health disparity;health equity;health inequalities;Health Sciences;Health Status;Healthcare;Home;improved;innovation;Institution;Integrated Health Care Systems;inter-institutional;Intervention;Investments;Kentucky;Lead;life span;Malignant Neoplasms;Medical;Medical center;Mission;Modeling;National Center for Advancing Translational Sciences;Neurosciences;new technology;Obesity;opioid abuse;Participant;patient engagement;Patients;Persons;Phase;Policies;Population;Positioning Attribute;programs;Quality of life;recruit;Reporting;Research;Resources;response;Rural;rural area;Rural Community;Rural Health;Science;Sports;Substance abuse problem;Substance Use Disorder;Translational Research;Translations;Underserved Population;United States;Universities;West Virginia;Work

PROJECT_TITLE: Kentucky Center for Clinical and Translational Science


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Prevention;Skin Cancer

ORG_CITY: Mountain View

ORG_NAME: ENSPECTRA HEALTH, INC.

PHR: Enspectra Health, Inc. is continuing its mission to increasingly move skin cancer detection earlier where the healthcare cost and burden to patients is minimal. In this project, we aim to pair the analytic power of the data generated by our novel, noninvasive cellular imaging technology (VIO) with deep learning algorithms to identify problematic precancers in patients before they progress to malignancy. By far, the greatest innovation of this project will be accomplishing our aims without the need of even a single biopsy.

PI_NAMEs: SANCHEZ, GABRIEL NESTOR (contact)

PROGRAM_OFFICER_NAME: ZHAO, MING

PROJECT_TERMS: Acceleration;Actinic keratosis;Address;Affect;algorithm training;Algorithms;American;Atypia;Award;Base Sequence;Biopsy;Biopsy Specimen;Cancer Detection;care burden;cellular imaging;Classification;Clinical;Clinical Trials;Color;Computer software;cost;Coupled;Cream;Data;Data Set;Databases;deep learning algorithm;Dermatologist;Dermatology;Detection;Diagnosis;Diagnostic;digital;digital pathology;Enrollment;Epidermis;Evaluation;Excision;Fiber;Fluorouracil;follow-up;Functional disorder;Generations;Goals;Health;Health Care Costs;Healthcare Systems;high risk;Histologic;Histology;Histopathology;Human;Human body;Image;imaging system;Imaging technology;improved;in vivo;in vivo imaging;in vivo imaging system;innovation;Intervention;Lasers;Learning;Lesion;Literature;Malignant - descriptor;Malignant Neoplasms;Measures;Medical History;Melanoma;Methods;Microscope;Mission;Modality;Modern Medicine;Morbidity - disease rate;Motivation;Multicenter Trials;multidimensional data;multimodal data;Multimodal Imaging;multiphoton microscopy;non-invasive imaging;novel;Oncology;Operative Surgical Procedures;Optics;Outcome;Pain;Pathologic;Pathology;Patient-Focused Outcomes;Patients;payment;personalized predictions;Persons;Phase;photomultiplier;Physiologic pulse;point of care;portability;predicting response;premalignant;Preparation;Probability;Process;progression risk;Recurrence;reflectance confocal microscopy;Resolution;response;Risk;Scanning;Screening for cancer;Screening for Skin Cancer;Severities;Silicon;Skin;skin biopsy;Skin Carcinoma;Slide;Sorting;Specimen;spectrograph;Squamous cell carcinoma;Stains;System;Technology;therapy outcome;Thick;Training;Validation

PROJECT_TITLE: Noninvasive prediction of skin precancer severity using in vivo cellular imaging and deep learning algorithms.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: PEDIATRICS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Project Narrative Childhood cancer survivors are at risk for adverse late health effects from their treatment, but many disengage from follow-up care during the transition from pediatric to adult-oriented health care. The proposed randomized trial will evaluate a novel digital self-management and peer mentoring intervention designed to improve self- management behaviors, enhance health-related quality of life, and increase adherence to guideline-concordant care among adolescent and young adult survivors. Results will advance clinical practice to reduce the long-term burden among this vulnerable group.

PI_NAMEs: DEVINE, KATIE A (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: Accountability;Address;Adherence;Adolescent and Young Adult;Adult;Age;aged;Appointment;arm;barrier to care;Behavior;burden of chronic illness;Cancer Center;cancer therapy;Cardiovascular Diseases;Caring;Childhood;childhood cancer survivor;clinical practice;critical developmental period;critical period;digital;digital platform;Disparity;Education;efficacious intervention;efficacy evaluation;efficacy trial;Emotions;Enrollment;ethnic health disparity;experience;Failure;feasibility trial;Feedback;Financial Hardship;follow-up;Future;Goals;Guidelines;Health;Health behavior;health management;health record;health related quality of life;Health Services Accessibility;Healthcare;Hispanic;improved;Informal Social Control;innovation;Insurance;interest;Intervention;Knowledge;Late Effects;Latino;Learning Module;Link;Longterm Follow-up;low health literacy;Malignant Childhood Neoplasm;Malignant Neoplasms;Managed Care;Mediating;Mediator;medical appointment;Medical Records;Mental Health;mobile application;Monitor;neoplasm registry;Neurocognitive;novel;Online Systems;Outcome;Outcome Measure;Parents;Participant;Pediatric Oncology Group;peer coaching;poor health outcome;Quality of life;racial disparity;Randomized;randomized trial;Recommendation;Recording of previous events;Reporting;Research;Risk;Sampling;scale up;Screening for cancer;screening guidelines;Self Care;Self Efficacy;Self Management;skills;social;social health determinants;Social support;Socioeconomic Status;Subgroup;Surveillance Program;Survivors;survivorship;Testing;theories;therapy design;Translating;Translations;treatment as usual;treatment center;treatment effect;Treatment Efficacy;usability;virtual;Vulnerable Populations;young adult

PROJECT_TITLE: Digital Self-Management and Peer Mentoring Intervention to Improve the Transition from Pediatric to Adult Health Care for Childhood Cancer Survivors


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE This proposal aims to identify cognitive strategies and brain mechanisms that humans use to learn about their environment and update the decision-making strategies. Since many neurological disorders impact decision-making, understanding the (diversity of) strategies humans apply to relate their decision-making process to their environment and how these strategies are enacted by the brain is the first step to identifying mechanisms of dysfunction and producing translational treatments and diagnostics. By applying an interdisciplinary approach of computational modeling, behavioral experiments, and human brain recordings, this work can improve our understanding of flexible decision-making, linking behavior to neural activity in a systematic way that sets the groundwork for future endeavors into human cognition and deficits in it.

PI_NAMEs: EISSA, TAHRA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TITLE: Cognitive and Neural Strategies for Latent Feature Inference


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Endocrine Disruptors;Kidney Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The premise of the present proposal is that intrauterine inflammatory processes disrupt kidney development and that environmental chemicals also impair renal this growth during gestation and postnatal development via oxidant stress. We further interrogate this hypothesis by examining phthalates, bisphenols, glyphosate and organophosphate pesticides as modifiable risks. We will test these hypotheses in the New York University Children's Health and Environment Study, one of the participating cohorts in the NIH Environmental Influences and Child Health Outcomes Program.

PI_NAMEs: MALAGA-DIEGUEZ, LAURA ;TRASANDE, LEONARDO  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: 8-hydroxy-2'-deoxyguanosine;Academic Medical Centers;Actins;Acute;Adolescent;Adoption;Adult;adverse childhood events;Age;Age Months;Attention;Biological Markers;Birth;cardiovascular risk factor;Case/Control Studies;Categories;Cell membrane;Chemicals;Child;Child Health;Childhood;Chronic;Chronic Kidney Failure;cohort;Complex;Consumption;cost efficient;Coupling;cytokine;Cytoskeleton;Data;Development;Developmental Biology;diagnostic biomarker;disorder risk;early childhood;Environment;environmental chemical;Environmental Exposure;Environmental Health;Environmental Risk Factor;Epidermal Growth Factor;experience;Exposure to;F2-Isoprostanes;Failure;Fetal Growth;Fetal Growth Retardation;follow-up;Food;Funding;glomerular filtration;glyphosate;Growth;Health;Herbicides;Impairment;in utero;Incidence;infancy;Infant;Inflammation;Inflammatory;Injury;Injury to Kidney;Interleukin-6;ITGB3 gene;Kidney;Laboratories;Life;Low Birth Weight Infant;Measurement;Measures;Medical;medical schools;modifiable risk;Modification;Motility;nephrogenesis;Nephrology;Nephrons;nephrotoxicity;New York;Obesity;Organic Food;Organophosphates;Outcome;oxidant stress;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Patients;Perinatal;Pesticides;Pharmaceutical Preparations;Phenotype;phthalates;podocyte;Population;Population Study;postnatal;postnatal development;Pre-Eclampsia;Pregnancy;Pregnant Women;premature;prenatal;prenatal exposure;Prevention;Process;Productivity;programs;prospective;Proteinuria;rat KIM-1 protein;Renal function;Renal glomerular disease;Renal Mass;Reporting;Risk;Risk Factors;risk stratification;Role;Sampling;Serum;Signal Transduction;specific biomarkers;stressor;Testing;Third Pregnancy Trimester;Toddler;trend;Tubular formation;Ultrasonography;United States National Institutes of Health;Universities;urinary;Urine;Urokinase Plasminogen Activator Receptor;Work

PROJECT_TITLE: Developmental Origins of Kidney Function in Early Life and Environmental Risks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-E(02)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: PROJECT NARRATIVE Annually, about 50,000,000 doses of synthetic gadolinium imaging contrast agents are injected into patients worldwide when getting an MRI scan. While these agents are extremely safe, they have the potential for adverse effects in some patient populations, which may accumulate when a procedure is repeated. We propose to develop the use of sugar (D-glucose) as a biodegradable contrast agent for imaging tumor physiology with MRI; we will first develop and translate this approach for brain cancer, after which the technology can be adjusted for use in other cancers and other disorders.

PI_NAMEs: KNUTSSON, LINDA ;VAN ZIJL, PETER CM (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Address;Adverse effects;Affect;anatomic imaging;Anatomy;Animal Model;Biometry;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Bone Tissue;Brain;Brain imaging;Brain Neoplasms;brain tissue;cancer imaging;Chemicals;Clinic;Clinical;clinical application;Clinical Oncology;clinical translation;clinically relevant;Collaborations;Computer software;computerized data processing;contrast enhanced;contrast imaging;Contrast Media;cost;Data;data acquisition;Data Analyses;deep learning;design;Detection;Development;Diabetes Mellitus;Diagnostic;Disease;Dose;Endocrinology;experience;extracellular;Gadolinium;Glucose;Glucose tolerance test;glucose transport;Goals;Healthcare;Image;Industry;Infusion procedures;Intravenous;Isotopes;Kidney Diseases;Label;Leadership;Legal patent;Licensing;Magnetic Resonance Imaging;Magnetism;Malignant neoplasm of brain;Malignant Neoplasms;Manufacturer;Metabolism;Metals;Methodology;Methods;Modernization;Monitor;Motion;MRI Scans;multidisciplinary;noninvasive diagnosis;Outcome;patient population;Patients;Performance;Perfusion;Physics;Physiologic pulse;Physiology;Play;Population;Predisposition;Procedures;Process;prognostic;Protocols documentation;psychologic;Relaxation;Reporting;Reproducibility;Research;Resource Sharing;Resources;Risk;Role;Running;Safety;Scanning;Sensitivity and Specificity;side effect;Signal Transduction;Standardization;statistics;sugar;Technology;technology development;Therapeutic;Time;timeline;Tissues;Toxic effect;Translating;Translations;treatment response;tumor;Universities;uptake;Validation;Visualization;Water;Work

PROJECT_TITLE: Development and Translation of D-glucose as a Diagnostic Agent for MRI of Cancer

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative Spinal cord injury (SCI) causes major neurological impairments including long-term sensorimotor deficits and posttraumatic neuropathic pain, with no effective treatment. The aim of our research is to understand the cellular and molecular mechanisms responsible for post-injury neuroinflammation in order to allow future development of novel therapies. In particularly we will target the signaling pathway of the voltage-gated proton channel Hv1, one of major ion channels expressed in resting microglia of the central nervous system, in order to decrease damage and increase functional recovery after SCI.

PI_NAMEs: WU, JUNFANG  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acidosis;Acute;Address;Affect;Astrocytes;Attenuated;Brain;Brain Injuries;Brain Ischemia;Cell Death;Central Nervous System;Charge;Chronic;Clinical;Compensation;Complex;Contusions;Coupling;Cytoplasm;Data;Development;effective therapy;Electrons;Failure;Functional disorder;functional improvement;functional outcomes;Future;gene therapy;Generations;Genetic;genetic approach;glial activation;Goals;Hyperesthesia;Immune system;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Injury;innovative technologies;insight;Interferons;Intervention;Ion Channel;Knockout Mice;Mediating;Microglia;Modeling;Molecular;mouse model;Mus;NADP;NADPH Oxidase;Neuroglia;neuroinflammation;Neurologic;Neurologic Dysfunctions;Neurological outcome;neuron loss;Neurons;neuroprotection;neurotoxic;new therapeutic target;novel;novel therapeutics;painful neuropathy;Pathologic;Pathway interactions;Phagocytes;pharmacologic;Phenotype;Process;Production;Protons;Reactive Oxygen Species;Recovery;Recovery of Function;Reporting;Research;Respiratory Burst;Rest;Role;Signal Pathway;Signal Transduction;Spinal Cord Contusions;Spinal cord injury;Testing;Therapeutic Intervention;Transgenic Mice;Up-Regulation;voltage

PROJECT_TITLE: The Function and Mechanisms of Voltage-Gated Proton Channel Hv1 in Spinal Cord Injury

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Complementary and Integrative Health;Drug Abuse (NIDA only);Natural Products;Neurosciences;Opioids;Pain Research;Prescription Drug Misuse;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative We aim to investigate the effects of cannabinoids and opioids for modulating pain, reward, and opioid use. Novel neuroimaging, behavioral and self-administration assays will allow us to study interactions between pain and reward pathways and evaluate the effects of these drugs on these systems.

PI_NAMEs: CAUDLE, ROBERT M (contact);NEUBERT, JOHN K

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acquired Immunodeficiency Syndrome;Acute;Acute Pain;Affect;Analgesics;Animals;Anorexia;Attention;Attenuated;Behavior;Behavior assessment;Behavioral;Behavioral Assay;behavioral outcome;Biological Assay;Brain;Cannabidiol;cannabinoid receptor;Cannabinoids;Cannabis;chemotherapy;Chronic;chronic pain;chronic pain management;chronic painful condition;Clinical;Clinical Trials;clinically relevant;Collaborations;comorbidity;Controlled Study;cost;Data;Dependence;Depressed mood;Disease;Dose;Dronabinol;drug discovery;Epidiolex;Euphoria;experimental study;Failure;Foundations;Future;Goals;heuristics;Human;human subject;Individual;innovation;Legal;Maps;Measures;Medical Marijuana;Modeling;Motor;multidisciplinary;Multiple Sclerosis;Mus;Nabilone;Nausea;neural;Neurobiology;neuroimaging;Neurosciences;novel;novel strategies;Opioid;Opioid Analgesics;opioid epidemic;Opioid Receptor;opioid sparing;opioid use;Outcome;Outcome Measure;Oxycodone;oxycodone self-administration;Pain;pain behavior;Pain Clinics;pain inhibition;Pain management;Pain Measurement;pain model;pain reduction;pain relief;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Placebo Effect;pre-clinical;prescription opioid;programs;Property;Psychological reinforcement;Public Health;PubMed;Rattus;Recreational Drugs;Reflex action;Reporting;Research;response;Rewards;Risk;Rodent;Sedation procedure;Seizures;Self Administration;side effect;Societies;substance use;Substance Use Disorder;synergism;System;Tail;Testing;Tetrahydrocannabinol;Translating;Translations;Variant;Ventilatory Depression

PROJECT_TITLE: Opioid and cannabinoid interactions in pain and reward

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BETHLEHEM

ORG_DEPT: BIOLOGY

ORG_NAME: LEHIGH UNIVERSITY

PHR: PROJECT NARRATIVE This project will investigate the fundamental circuit interactions between excitatory and inhibitory neurons underlying neural coding within the mouse olfactory bulb, the first region of the mammalian brain where peripheral olfactory sensory input is processed. Neural coding within the relatively compact architecture of the olfactory bulb supports perception of extremely complex and varied environmental stimuli, making the olfactory bulb a preeminent model for studying general principles of brain function. Knowledge gained through this project about how specific inhibitory interneuron classes influence excitatory neuron output from the olfactory bulb may further provide key insight into the widespread disruption of olfactory perception observed in several neurological disorders, including Alzheimer's disease and Parkinson's disease.

PI_NAMEs: BURTON, SHAWN DENVER (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Acute;Address;Alzheimer's Disease;Architecture;Behavior;Biological Models;Brain;Brain region;cell type;Cells;Cholecystokinin;Code;Complex;Consensus;Data;Dendrites;Dependence;Distal;Elements;excitatory neuron;gamma-Aminobutyric Acid;Generations;Genetic;Glutamate Receptor;granule cell;Hippocampus;Histology;Human;Image;Individual;inhibitory neuron;insight;Interneuron function;Interneurons;Investigation;Ion Channel;Knowledge;Lateral;Link;Mammals;Measures;Mediating;Morphology;Mus;Neocortex;nerve supply;Nervous System Disorder;neural;Neurons;olfactory bulb;Olfactory Pathways;organizational structure;Output;Parkinson Disease;Pattern;Perception;Peripheral;Pharmacology;postsynaptic;Prevalence;Process;Property;reconstruction;Recurrence;Regulation;Rodent;Role;Sensory;Sensory Deprivation;sensory input;Signal Transduction;simulation;Site;Slice;Smell Perception;Stimulus;Study models;Synapses;synaptic inhibition;Target Populations;Testing;Viral;Whole-Cell Recordings;Work

PROJECT_TITLE: Circuit functions of fast-spiking interneurons in the main olfactory bulb

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: TUSCALOOSA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

PHR: Narrative Misfolding and aggregation of specific proteins into fibrillar aggregates is the pathological hallmark of many diseases, but the precise relationship between molecular structure of aggregates and their heterogeneities and disease pathology is yet to be fully understood. This project aims to develop a set of experimental approaches using nanoscale infrared spectroscopy and confocal infrared imaging to investigate the heterogeneities of secondary structure in amyloid aggregates and explore their correlation with disease progression. The primary focus of this approach will be to study amyloid aggregates in Alzheimer’s disease, and the methods developed herein will be extended to study other amyloid diseases.

PI_NAMEs: GHOSH, AYANJEET  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: aggregation pathway;Alzheimer's Disease;Alzheimer's disease patient;Amyloid;Amyloidosis;Atomic Force Microscopy;Classification;cytotoxicity;Data;Deposition;Disease;Disease Progression;Genetic Polymorphism;Growth;Heterogeneity;Image;imaging approach;In Vitro;infrared microscopy;infrared spectroscopy;Malignant Breast Neoplasm;Maps;Measurement;Methods;molecular pathology;Molecular Structure;nanoscale;Neurodegenerative Disorders;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Play;Proteins;Public Health;Secondary Protein Structure;spectroscopic imaging;Structure;Techniques;Technology;therapeutic development;Tissue Extracts;Tissues

PROJECT_TITLE: Investigating structural heterogeneities in amyloid aggregates with multiscale infrared spectroscopic imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: GEORGIEFF, MICHAEL K.;WILSON, SYLIA  (contact);ZILVERSTAND, ANNA

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 17/24 Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: LA JOLLA

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Alterations in the growth and differentiation of epidermal stem and progenitor cells can lead to a variety of skin disorders including non-melanoma skin cancers as well as ichthyosis. Thus a comprehensive understanding of the mechanisms that regulate epidermal growth and differentiation is necessary to understand the progression to disease. This proposal seeks to characterize the mechanisms of epidermal self-renewal and differentiation through the regulation of transcription elongation.

PI_NAMEs: SEN, GEORGE L (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: 3-Dimensional;Address;Adult;Atopic Dermatitis;Basement membrane;Binding;CDC2 gene;Cell Differentiation process;Cell Proliferation;Cells;ChIP-seq;Chromatin;chromatin immunoprecipitation;clinically relevant;Complex;Dermal;design;Development;Developmental Gene;Differentiated Gene;Differentiation and Growth;Disease;Drosophila genus;Elongation Factor;Embryo;embryonic stem cell;Environment;epidermal stem cell;Epidermis;Epigenetic Process;Equilibrium;experimental study;FGFBP1 gene;Generations;Genes;Genetic Transcription;Growth;Homeostasis;Human;Immune;knock-down;loss of function;migration;Modeling;Molecular;Mus;Natural regeneration;negative elongation factor;next generation sequencing;Play;Polymerase;Population;Process;Productivity;programs;Proliferating;promoter;Proteins;Psoriasis;recruit;Regulation;Reporting;Research Design;RNA Polymerase II;Role;self-renewal;Signal Transduction;Skin;Skin Carcinoma;skin disorder;stem;stem cell proliferation;stem cell self renewal;stem cells;Stratified Epithelium;Stratum Basale;Stratum corneum;Tissues;Transcription Elongation;transcription factor;Transcription Initiation;Transcriptional Elongation Factors;Transcriptional Regulation

PROJECT_TITLE: Regulators of epidermal growth and differentiation

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Nutrition;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Dementia remains a leading cause of mortality and morbidity worldwide and high levels of salt in the diet have emerged as a factor that increases the risk of developing cognitive impairment. The present application seeks to find out how a diet rich in salt acts on brain vessels and leads to accumulation in the brain of the protein tau, a major culprit in Alzheimer’s disease. The proposed studies open the way to new approaches to protect the brain from the harmful effects of excessive dietary salt.

PI_NAMEs: IADECOLA, COSTANTINO  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: adaptive immune response;Adhesions;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Automobile Driving;Bacteria;base;Blood capillaries;Blood Circulation;Blood Pressure;blood pressure elevation;Blood Vessels;Brain;brain dysfunction;brain endothelial cell;brain health;Cardiovascular Diseases;cardiovascular risk factor;Cells;Cerebral endothelium;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Cognition;Cognitive;Cognitive deficits;Consumption;cytokine;Data;Dementia;Diet;dietary excess;Dietary Factors;dietary salt;Dietary Sodium;Down-Regulation;Endothelial Cells;endothelial dysfunction;Endothelium;Event;Excess Dietary Salt;experimental study;Female;Flow Cytometry;Food;Functional disorder;Funding;genetic regulatory protein;Goals;Health;Helper-Inducer T-Lymphocyte;high salt diet;Human;hyperphosphorylated tau;Hypertension;hypoperfusion;IL17 gene;Immune;Immunologics;Impaired cognition;Impairment;improved;in vivo;Individual;Innate Immune Response;insight;Lactobacillus;Leukocytes;Life;Light;Link;link protein;male;Mediating;Mediator;microbiota;Microtubule-Associated Proteins;Microvascular Dysfunction;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Neurons;neurovascular;Nitric Oxide;NOS3 gene;novel;novel strategies;old mice;Perfusion;Phase;Phosphorylation;Policies;Production;programs;Public Health;receptor;Receptor Activation;reconstitution;Reporter;Research;response;Rest;Risk;Risk Factors;Role;salt intake;salt sensitive;Scaffolding Protein;Science;Small Intestines;Sodium Chloride;Source;Stroke;success;tau aggregation;tau Proteins;Tauopathies;Testing;Time;transcriptome sequencing;Translating;two photon microscopy;Vascular Endothelium

PROJECT_TITLE: Dietary Sodium, Neurovascular Dysfunction and Cerebrovascular Risk

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]