NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE Relevance to public health: Candida glabrata, an important human fungal pathogen and second leading cause of invasive candidiasis, can infect a wide variety of immunocompromised individuals, represents a significant threat to global public health and commonly shows resistance to antifungal drugs, especially azoles. This application will determine how translational efficiency mechanisms control azole resistance in C. glabrata. Ultimately, this study will provide a better understanding of global translational regulatory circuits and pathways that control C. glabrata drug resistance as well as identify and characterize several key factors important for this process that could potentially serve as targets for the development of novel and more effective antifungal strategies.

PI_NAMEs: KADOSH, DAVID  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: 5' Untranslated Regions;Acquired Immunodeficiency Syndrome;Anabolism;anti-fungal agents;Automobile Driving;Azole resistance;Azoles;Bioinformatics;Cancer Patient;Candida;Candida albicans;Candida glabrata;Candidiasis;Cells;Centers for Disease Control and Prevention (U.S.);chemotherapy;Chromosomal Rearrangement;Classification;Clinical;clinically significant;Data;Death Rate;Development;Drug Efflux;Drug resistance;effective therapy;efflux pump;Ergosterol;Event;Filament;Fluconazole;Fungal Drug Resistance;Genes;Genetic;Genetic Transcription;genome-wide;Goals;Human;Immunocompromised Host;Individual;Infection;Laboratories;Lanosterol;Life;Mediating;Monitor;Morbidity - disease rate;Mucous Membrane;mutant;new therapeutic target;novel;novel therapeutics;organ transplant recipient;overexpression;Oxidative Stress;Pathogenesis;pathogenic fungus;Pathway interactions;Patients;Pharmaceutical Preparations;Play;Point Mutation;Predisposition;Process;Property;Protein Biosynthesis;protein expression;Proteins;Proxy;Public Health;Resistance;resistance frequency;resistance mechanism;response;ribosome profiling;Role;Saccharomyces cerevisiae;Sepsis;Testing;therapeutically effective;trait;Transcript;transcriptome sequencing;Translational Regulation;Translations;Treatment Protocols;treatment response;Virulence;whole genome;Work;Yeasts

PROJECT_TITLE: Translational Regulation of Candida glabrata Azole Resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(82)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative We recently identified 13 bacterial viruses (bacteriophage) that predict good versus poor growth in children with environmental enteric dysfunction. How each of these bacteriophage interact with the bacterial microbiome is not known. Here, we will define their bacterial hosts, then culture and further characterize these bacteriophage to begin to determine their contributions to health and disease.

PI_NAMEs: HOLTZ, LORI R (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Affect;Agar;Age;Animal Model;Bacteria;bacterial community;Bacterial Genome;Bacteriolysis;bacteriome;Bacteriophages;Biology;Cause of Death;Cell Separation;Cells;Child;Child Development;Child Health;Childhood;Colorectal Cancer;Communities;Complex;Data;deep sequencing;Diabetes Mellitus;Diagnosis;Disease;Disease Marker;DNA amplification;Dyes;dysbiosis;Enteral;Equilibrium;experimental study;Feces;fitness;Fluorescence-Activated Cell Sorting;Functional disorder;Future;genetic signature;Genome;Genomics;global health;Growth;gut health;gut microbiome;Health;Human;Human body;Hypertension;Immune response;Impairment;in silico;Individual;Inflammatory;Inflammatory Bowel Diseases;interest;Intervention;Knowledge;Label;Link;Longitudinal cohort;low and middle-income countries;Lytic;Mechanics;Methods;microbial;microbial signature;microbiome composition;Molds;mortality;Necrotizing Enterocolitis;novel;novel strategies;Nucleic Acids;optical spectra;Population;Preschool Child;prevent;Prevention;Process;Prokaryotic Cells;Publishing;Reagent;Rural;Sampling;screening;stool sample;Techniques;Viral;virome;Virus;virus culture

PROJECT_TITLE: Propagation and Characterization of Phage Related to Human Growth

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Networking and Information Technology R&D (NITRD);Nutrition;Pediatric;Physical Activity;Prevention;Sleep Research

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Over the last 10 years, the technology in consumer wearable devices has improved their ability to collect heart rate and movement via accelerometry noninvasively to measure free-living physical activity energy expenditure and sleep. No studies have examined the validity of consumer wearable devices for children ages 5 to 12 years. This project is significant because it will be among the first to establish the use of consumer wearable devices, which have the ability to estimate free-living physical activity energy expenditure and sleep of youth.

PI_NAMEs: WEAVER, ROBERT G (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: 12 year old;Acceleration;Accelerometer;actigraphy;Adult;Age;Algorithms;application programming interface;battery life;Behavior;Biometry;Chest;Child;Clinical;Collection;Complex;Data;design;design verification;Devices;Electrocardiogram;Energy Metabolism;Epidemiology;epidemiology study;Equation;Expenditure;experience;fitbit;fitness;Gait abnormality;Goals;Health;Heart Rate;Hour;improved;Indirect Calorimetry;innovation;Intervention;Intervention Studies;Laboratories;Learning;Link;Machine Learning;Measurement;Measures;Methods;Monitor;motion sensor;Movement;Nature;neuromuscular;older adult;online repository;open source;Outcome;Output;Pattern;Persons;Photoplethysmography;Physical activity;Physical assessment;Polysomnography;Population;Process;Protocols documentation;Research;Research Personnel;Research Priority;sedentary;Series;Signal Transduction;Sleep;sleep behavior;Sleep Disorders;Statistical Models;Techniques;Technology;Telemetry;Testing;Time;United States National Institutes of Health;Validation;validation studies;Vision;wearable device;wearable sensor technology;Youth

PROJECT_TITLE: Validity and Utility of Consumer-based Wearable Fitness Trackers to Monitor Free-Living Physical Activity Energy Expenditure and Sleep in Children 5-12 Years Old

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE In premature infants and people with specific alterations to immune function, Candida albicans causes infections of the central nervous system (CNS) leading to death or devastating neurodevelopment deficits in surviving patients. Very little is known about the mechanisms by which C. albicans causes CNS disease. Our project aims to use a novel mouse model of C. albicans CNS infection to characterize the transcription factors required to cause CNS disease. This exploratory grant will set the stage for more in-depth studies with the ultimate goal of identifying potential strategies to prevent or better treat these infections.

PI_NAMEs: KRYSAN, DAMIAN J (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Adopted;Adult;Affect;age group;Aspergillus;Bacteria;Bacterial Infections;Bar Codes;Biological Assay;Body System;Brain;brain endothelial cell;brain tissue;Candida;Candida albicans;Candidiasis;Cell Communication;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Cessation of life;Clinical;clinically relevant;Coccidioides;cohort;Collection;congenic;Cryptococcus;Development;Disease;Disseminated candidiasis;Environment;experimental study;Eye;fitness;fungus;Future;Gastrointestinal tract structure;Genes;Genetic;genetic analysis;Genetic Screening;Genetic Transcription;Goals;Grant;high risk;Histoplasma;Human;immune function;Immune response;Immunosuppression;in vivo;Individual;Infant;infant infection;infant outcome;Infection;innate immune pathways;Interleukin-1;Interleukin-1 Receptors;Intravenous;Kidney;Knowledge;Libraries;Liver;Lung;Mediating;Meningoencephalitis;Modeling;mouse model;Mouse Strains;Mus;mutant;Mutation;nano-string;neurodevelopment;Neurotropism;novel;Oral cavity;Organ;Organism;oropharyngeal thrush;pathogen;Pathogenesis;pathogenic fungus;Patients;Persons;Pregnancy;Premature Infant;prevent;Protein Kinase;Research;response;Risk;Role;Route;Sepsis;Site;Spleen;Standard Model;Survivors;Technology;transcription factor;Virulence;Wild Type Mouse;Work

PROJECT_TITLE: Systematic Genetic Analysis of C. albicans CNS Infection

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

PHR: PROJECT NARRATIVE This project will study a new policy that eliminated bus fare citywide in Kansas City, MO. The policy's impact on bus ridership and associated impacts on physical activity, healthy eating, weight status, and economic barriers to health will be evaluated. If the policy is supportive of health without other detrimental consequences, it may be more likely to be continued and expanded in other cities across the US.

PI_NAMEs: BERKLEY-PATTON, JANNETTE YVONNE (contact);CARLSON, JORDAN A.

PROJECT_TERMS: Accelerometer;Address;Adopted;Advocacy;authority;behavioral economics;Body mass index;built environment;Characteristics;Chronic Disease;Cities;Communities;comparison control;COVID-19 pandemic;Crime;Data;density;design;Diabetes Mellitus;Diabetes prevention;Economic Conditions;Economics;Electronic Health Record;Environment;Evaluation;experience;experimental study;Federal Government;Focus Groups;General Population;Health;health economics;Health Food;Health Services;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Healthy Eating;Height;improved;Income;Infrastructure;Kansas;Knowledge;Lead;Local Government;Low income;Low Income Population;Measures;Methods;Natural experiment;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;pandemic disease;pandemic impact;Participant;Patients;Perception;Physical activity;Policies;Policy Maker;Population;pre-pandemic;Primary Health Care;Public Policy;Quasi-experiment;Questionnaires;recruit;Research Personnel;Risk Reduction;Sampling;Selection Bias;sociodemographics;socioeconomics;Source;State Government;Surveys;Testing;tool;Transportation;trend;usability;walkability;Weight

PROJECT_TITLE: Health Impacts of City-Wide Zero-Fare Bus Transit: A Natural Experiment

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The majority of rural Americans are not sufficiently active to achieve health benefits; social support interventions and civic engagement projects to change the built environment are promising strategies to increase physical activity. We will randomize 16 communities to receive either a group-based walking program or combined group-based walking plus civic engagement program. Working with rural libraries, we will increase their capacity to implement the programs; we will evaluate change in physical activity, cardiovascular fitness, and health outcomes in participants in both programs and conduct an implementation and process evaluation.

PI_NAMEs: PERRY, CYNTHIA KAY (contact);SEGUIN-FOWLER, REBECCA ANNE

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Address;Adult;Alcohol consumption;built environment;Cardiovascular Diseases;cardiovascular fitness;Chronic;Chronic Disease;cohesion;Communities;community-level factor;comparative;comparative effectiveness study;Cost Analysis;Data;Development;Diet;Disease;Disparity;disparity reduction;Effectiveness;Enrollment;Environment;Evaluation;evidence base;Evidence based program;exercise intervention;experience;fitness;Funding;Future;Geography;Goals;Grant;Health;Health Benefit;health disparity;Health Promotion;implementation evaluation;improved;Individual;innovation;Intervention;intervention effect;intervention program;Libraries;Malignant Neoplasms;Measurement;Mediator;Modeling;modifiable risk;novel strategies;Outcome;Participant;Physical activity;physical inactivity;process evaluation;Program Effectiveness;programs;Public Health;Randomized;Recommendation;Reduce health disparities;Research;Resources;Risk Factors;Rural;rural Americans;Rural Community;rural dwellers;Self Efficacy;social cohesion;social factors;Social support;therapy design;Tobacco use;Urban Community;walkability;Walking;walking program;webinar;World Health Organization

PROJECT_TITLE: Rural Libraries Promoting Walking and Walkability in Their Rural Communities

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Physical Activity

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE The current proposal seeks to understand why metformin appears to have negative effects on mitochondrial adaptations under certain conditions. The project proposes that how well mitochondria work may dictate a positive or negative outcome during metformin treatment. Understanding these mechanisms will help avoid detrimental outcomes in individuals who take metformin to prolong the healthspan.

PI_NAMEs: MILLER, BENJAMIN FRANCIS (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Aerobic;Aerobic Exercise;Affect;Age Months;age-related disease;Agreement;Bioenergetics;CCRL2 gene;Chronic Disease;Clinical Trials;Complex;Drug Kinetics;Drug Prescriptions;Energy Transfer;Exercise;exercise training;Free Energy;Health;healthspan;imaging approach;improved;improved outcome;In Vitro;in vivo;in vivo imaging;Individual;insulin sensitivity;interest;Kinetics;life span;Measures;Mediating;Metabolic;Metabolic dysfunction;meter;Metformin;Mitochondria;Modeling;Morphology;Muscle Mitochondria;NADH dehydrogenase (ubiquinone);Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Outcome;Oxidation-Reduction;pleiotropism;Process;Proteomics;Publishing;Rattus;Reporting;response;Risk;Running;sedentary;Skeletal Muscle;Specificity;Spirometry;Stress;Testing;Thermodynamics;Tissues;trait;treadmill;Work

PROJECT_TITLE: Determining the context specificity of metformin treatment on muscle mitochondria and healthspan


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_CITY: BOZEMAN

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Project Narrative  The ability for Herpes Simplex virus type 1 (HSV-1) to productively replicate or establish silent infection in neurons is a poorly understood process that directly influences HSV-1 disease. In this proposal, we characterize HSV-1 replication and cellular transcription using drop-based microfluidic approaches to assess the diversity of replication outcomes with single-cell resolution. These analyses will provide incredible insight into the effect of the cellular environment on the range of HSV-1 replication in neurons and subsequent disease.

PI_NAMEs: TAYLOR, MATTHEW P. (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Address;Afferent Neurons;cell type;Cells;Classification;Cluster Analysis;Cytopathology;Detection;Development;Devices;differential expression;Disease;Dose;Drops;Encapsulated;Encephalopathies;Environment;Event;experimental study;Gel;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Transcription;Goals;Growth;Herpesvirus 1;human pathogen;Hydrogels;Image;In Vitro;in vivo;Individual;Infection;insight;Kinetics;latent infection;Lesion;Lytic;Measures;Mediating;Methods;microfluidic technology;Microfluidics;Modeling;Neurons;novel;orofacial;Outcome;Peripheral Nervous System;permissiveness;Phenotype;Process;Productivity;Proteins;Recurrence;Resolution;response;single cell analysis;single-cell RNA sequencing;Structure;System;Testing;Time;Tissues;Transcript;transcriptome;trend;Viral;viral detection;Viral Genome;viral RNA;Virus Diseases;Virus Replication

PROJECT_TITLE: Identifying heterogenous neuronal responses to HSV-1 infection with drop-based microfluidics

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This proposal is aimed at determining the mechanism and function of the novel supercomplex KARATE that controls AKT phosphorylation in insulin signaling, providing significant insight into diabetes and obesity.

PI_NAMEs: IIJIMA, MIHO  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: 3-Phosphoinositide Dependent Protein Kinase-1;Adenylate Cyclase;Adipocytes;Adipose tissue;Affect;Amoeba genus;Applications Grants;Binding;Biochemical;biological systems;Biology;Bioreactors;Blood;Blood Glucose;blood glucose regulation;Catalytic Domain;Cell Fractionation;Cell Line;Cell membrane;cell motility;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cryoelectron Microscopy;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Diabetes Mellitus;Dictyostelium;Dictyostelium discoideum;Event;Foundations;FRAP1 gene;Future;Glucose;glucose production;Glucose Transporter;glucose uptake;glucose-regulated proteins;GLUT 4 protein;Glycogen;Goals;GTP Binding;Homologous Gene;Human;Hydrophobicity;In Vitro;in vivo;inhibitor;innovation;insight;Insulin;Insulin Receptor;Insulin Resistance;insulin signaling;Knock-out;Knockout Mice;Knowledge;KRAS2 gene;Link;Lipids;live cell imaging;Liver;Mammalian Cell;Mediating;Medical;Metabolic;Metabolic syndrome;Molecular;Monomeric GTP-Binding Proteins;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organ;Pancreas;Peptides;Persons;PH Domain;Phosphatidylinositols;Phosphorylation;Phosphotransferases;Physiological;PIK3CG gene;Post-Translational Protein Processing;Prevalence;protein activation;Protein Biosynthesis;Protein Kinase;Protein-Serine-Threonine Kinases;Proteins;Proto-Oncogene Proteins c-akt;Race;reconstitution;recruit;Regulation;Reporting;response;rho;RHOA gene;Role;Serine;Signal Transduction;Signal Transduction Pathway;Skeletal Muscle;social;Solid;Structure;System;Testing;Textbooks;Therapeutic Intervention;Threonine;Tissues;tool;Translating;TSC2 gene;Tyrosine Phosphorylation;United States;Work

PROJECT_TITLE: Mechanism and Function of the Supercomplex KARATE in Insulin Signaling

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: Foster city

ORG_NAME: MIRESOURCE, INC.

ORG_STATE: CA

PHR: NARRATIVE College-age youth do not have easy access to expert referral coordinators to get referrals to appropriate mental health care, due to the stigma of seeing a referral coordinator in-person, long wait times to get an intake appointment in the university counseling center, or limited or no referral counselors available in their higher-education institution. We propose to automate the referral process, focusing on college-age youth, by bridging online assessments and curated, up-to-date mental health provider networks. Our automated online referral platform will use expert-trained machine learning to provide users with personalized referrals for mental health care.

PI_NAMEs: KLEIN, ARNO  (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Address;Adolescent;Age;Agreement;Algorithms;Appointment;Attitude;biomedical referral center;Caring;Chi-Square Tests;Child;Classification;Clinical;Collection;college;commercialization;comorbidity;Computer software;Counseling;COVID-19 pandemic;Data;Data Collection;Data Set;design;Dimensions;Environment;Esthetics;Feedback;Female;Focus Groups;functional status;Future;Gender;health assessment;Health Personnel;Health Resources;higher education;Human;Impairment;improved;Individual;Infrastructure;innovation;Institution;Insurance;Intake;Internet;Knowledge;Learning Disorders;Machine Learning;machine learning algorithm;machine learning model;machine learning pipeline;male;Measures;Mental disorders;Mental Health;Mental Health Services;Mind;Modeling;novel;Pathology;Patients;Persons;Phase;Population;Privacy;Process;Professional counselor;Protocols documentation;Provider;provider networks;Psychiatrist;Psychologist;quality assurance;Recommendation;Recording of previous events;Research;Resources;response;Risk;satisfaction;Services;Small Business Technology Transfer Research;social stigma;Social Workers;software as a service;Source;Students;success;System;Technology Assessment;telehealth;Testing;tool;Training;Universities;university student;usability;Visit;Wait Time;young adult;Youth

PROJECT_TITLE: Automated Mental Health Referral System


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Pediatric

PHR: PROJECT NARRATIVE Congenital and acquired diseases of the heart, vasculature, and lungs remain among the most common causes of death in infancy, children, and young adults. The purpose of this training program is to attract and train young scientists to study fundamental mechanisms that underlie cardiorespiratory disease in childhood.

PI_NAMEs: BUBECK WARDENBURG, JULIANE  (contact);LAVINE, KORY J.

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Cardiovascular system;Childhood;Lung;Research Training;Training Programs

PROJECT_TITLE: Pediatric Cardiovascular and Pulmonary Research Training Program

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Patient Safety

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Project Narrative Cefiderocol is a novel siderophore cephalosporin that retains activity against Pseudomonas aeruginosa, a multidrug-resistant pathogen that is a leading cause of healthcare associated infections. This proposal seeks to understand the prevalence of changes in the cefiderocol import pathways in clinical isolates of P. aeruginosa and their association with cefiderocol resistance. It will provide information to guide detection of isolates at risk for resistance in the clinical microbiology laboratory, as well as an understanding of the mechanisms of cefiderocol resistance that emerge at clinically relevant doses of the antibiotic.

PI_NAMEs: MILLER, WILLIAM R (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Active Biological Transport;Affect;Antibiotic Resistance;Antibiotics;assay development;Bacteria;beta-Lactamase;beta-Lactams;Binding;Biological;Biological Assay;Blood;carbapenem resistance;Carbapenems;Caring;Centers for Disease Control and Prevention (U.S.);Cephalosporins;Clinical;Clinical Data;clinical development;Clinical Microbiology;clinical practice;clinically relevant;Cohort Studies;Collection;Data;Detection;Development;Diameter;Diffusion;Dose;Drug Exposure;Drug Kinetics;Endothelium;Evaluation;Exposure to;Fiber;Gene Mutation;Genetic Polymorphism;genome analysis;genome sequencing;Genomics;Geographic Locations;Geography;Goals;Growth;Healthcare;healthcare-associated infections;Hospital Referrals;Human;in vitro activity;Infection;inhibitor;insertion/deletion mutation;Integral Membrane Protein;Intensive Care Units;Intermediate resistance;International;Iron;Label;Laboratories;Link;Liquid substance;Lung;Mediating;Medical;medical vulnerability;Membrane;Methods;Minimum Inhibitory Concentration measurement;Modeling;Multi-Drug Resistance;multi-drug resistant pathogen;multidrug-resistant Pseudomonas aeruginosa;mutant;Mutation;Nonsense Codon;novel;Outcome;pathogen;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;periplasm;Pharmaceutical Preparations;Phenotype;Play;Population;Population Analysis;Predisposition;Prevalence;prevent;prospective;protein function;Proteins;Pseudomonas;Pseudomonas aeruginosa;public health emergency;receptor;Receptor Gene;Regimen;Regulation;Regulatory Pathway;Reporting;Resistance;resistance mechanism;Risk;Route;screening;Series;Siderophores;Site;Source;Stream;System;Test Result;Testing;Therapeutic Uses;tool;Toxic effect;Treatment Failure;uptake;Variant;whole genome

PROJECT_TITLE: Emergence of TonB-dependent receptor mediated cefiderocol resistance among multidrug-resistant (MDR) Pseudomonas aeruginosa clinical isolates.

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Rare Diseases

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because understanding what genes and pathways are responsible for the tumor formation in patients with OD and MS (untreatable diseases) and the degree to which they influence the medical outcomes related to cancer formation is expected to allow for more precise diagnosis of these patients and give rise to new types of treatments for patients with OD and MS and for patients with related, more common, non-syndromic forms of cancers such as chondrosarcomas and gliomas. Thus, this proposal is relevant to the part of NIH’s mission that pertains to fostering fundamental creative discoveries and innovative research strategies as a basis for ultimately protecting health.

PI_NAMEs: GORDON, CATHERINE M.;SOBREIRA, NARA  (contact);STEWART, DOUGLAS R

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Affect;base;Benign;biobank;Biological Assay;Blood Vessels;bone;Brain;cancer therapy;causal variant;Cells;Characteristics;Chondrogenic Neoplasm;Chondroma;Chondrosarcoma;Clinical;clinical center;clinical phenotype;cohort;comparison control;Creativeness;Data;Deformity;Development;Diagnosis;Diagnostic;differential expression;Disease;Down-Regulation;effective therapy;Enchondromatosis;Evaluation;exome sequencing;Family;Family member;Fibroblasts;Fostering;gain of function;gene discovery;Genes;Genetic;Genetic Transcription;Genome;genome sequencing;Genomics;Germ Lines;Glioma;Goals;Guidelines;Health protection;Heterogeneity;HIF1A gene;hypoxia inducible factor 1;Impairment;innovation;Investigation;Knock-in;Knowledge;Location;Luciferases;Maffucci Syndrome;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Malignant - descriptor;Malignant Neoplasms;Medical;Medical Genetics;Metabolic;Mission;Modeling;Mutate;Natural History;novel;Outcome;Pathway interactions;Patients;pharmacologic;Phenotype;Predisposition;Prevalence;prevent;proband;Public Health;Recording of previous events;Registries;Research;Resources;Roentgen Rays;Role;sample collection;Sampling;skeletal abnormality;Specimen;Syndrome;Techniques;Testing;transcriptome sequencing;tumor;United States National Institutes of Health;Variant;whole genome;Work

PROJECT_TITLE: Delineation of the natural history of Ollier disease and Muffucci syndrome and investigation of their genetic bases

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: LA JOLLA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Prion diseases are rapidly progressive, fatal neurodegenerative disorders caused by prion protein  aggregates spreading through the brain and spinal cord. We will use directed and unbiased  proteomics experiments to determine how prions trigger synaptic dysfunction and neuronal  degeneration in well-characterized, highly reproducible neuronal and animal model systems, as  well as patient samples. We expect that the proposed studies will elucidate the signaling pathways  that drive synapse loss in prion disease, and uncover new therapeutic targets.

PI_NAMEs: SIGURDSON, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: abeta oligomer;Acceleration;Affect;Alzheimer's Disease;AMPA Receptors;Animal Model;Automobile Driving;Binding;Binding Proteins;Biochemical;Biological Models;Brain;calmodulin-dependent protein kinase II;Cell Membrane Proteins;Chronic;Complex;conformer;Creutzfeldt-Jakob Syndrome;Critical Pathways;Data;Disease;Disease Progression;Dissection;Electron Microscopy;Electrophysiology (science);Endosomes;Event;Excision;excitatory neuron;excitotoxicity;experimental study;extracellular;Functional disorder;Funding;Genes;genetic manipulation;Glutamate Receptor;Glutamates;Goals;Hippocampus;Homeostasis;Human;Impairment;In Vitro;in vivo;Induced Neurons;Infection;insight;Light;Link;Location;Longitudinal Studies;Mass Spectrum Analysis;Membrane;Membrane Proteins;microvesicles;Modeling;Multivesicular Body;Mus;Mutate;Myoclonus;N-Methyl-D-Aspartate Receptors;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;neurotoxic;neurotoxicity;neurotransmission;new therapeutic target;Outcome;Pathologic;Pathway interactions;Patients;phosphoproteomics;Phosphorylation;Phosphotransferases;Physiological;postsynaptic;Postsynaptic Membrane;presynaptic;Prion Diseases;Prions;protein aggregation;protein complex;protein expression;protein transport;Proteins;Proteomics;proteostasis;PrP;PrPSc Proteins;Reactive Oxygen Species;receptor;Receptor Signaling;Reporting;Reproducibility;response;Sampling;Scaffolding Protein;Signal Pathway;Signal Transduction;Sorting;Spinal Cord;STEM research;Structure;Synapses;synaptic function;Synaptic plasticity;Synaptic Receptors;Synaptosomes;Testing;Time;trafficking;transcription factor;Transgenic Mice;Ubiquitin;Ubiquitination;Up-Regulation

PROJECT_TITLE: Mechanisms of Prion Spread and Neuronal Toxicity

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Kidney Disease

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Although vancomycin is the most commonly prescribed antibiotic to hospitalized patients in the United States, it unfortunately carries a well-known risk of kidney injury. The proposed research will test whether administration of vancomycin via a continuous infusion, as opposed to more traditional intermittent infusion, is less harmful to the kidneys based on specific measurements of kidney function and injury. If the infusion strategy influences toxicity as we hypothesize, it could mean safer use of this antibiotic for the millions of patients that receive this medication annually.

PI_NAMEs: COOK, AARON M (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Antibiotics;antimicrobial;Benefits and Risks;Biological Markers;Clinical;Clinical Data;Clinical Research;Clinical Trials;Communicable Diseases;Continuous Infusion;Creatinine;Data;Dose;Drug Kinetics;Eligibility Determination;experience;Glomerular Filtration Rate;Histology;Hospitalization;Hour;improved outcome;indexing;Infection;Infusion procedures;Injury;Injury to Kidney;Institution;Iohexol;Kidney;Measurement;Measures;methicillin resistant Staphylococcus aureus;Mission;Modeling;National Institute of Allergy and Infectious Disease;nephrotoxicity;novel strategies;novel therapeutics;open label;osteopontin;pathogen;Patients;Pattern;Pharmaceutical Preparations;Physicians;Plasma;post gamma-globulins;pre-clinical;prospective;Randomized;randomized, clinical trials;rat KIM-1 protein;Rattus;Renal function;Research;Risk;Safety;Scheme;Serum;standard of care;sulfated glycoprotein 2;Techniques;Testing;Time;tool;Toxic effect;Translating;United States;urinary;Vancomycin;Work

PROJECT_TITLE: A Randomized Clinical Trial of Continuous vs. Intermittent Infusion Vancomycin: Effects on Measured GFR and Kidney Injury Biomarkers

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Bioengineering;Digestive Diseases;Liver Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Given the steady rise of patients with liver disease in the United States, the demand for liver transplantation has continued to increase while the supply of organs has remained unchanged creating a pressing need to address this organ scarcity. Stem cell derived hepatocytes are often suggested as an alternative cell source for organ transplants, however, the current inability to derive robust and fully mature hepatocytes limits their clinical and scientific utility. The goal of this proposal is to identify and examine important cellular interactions for directed hepatocyte maturation in vitro.

PI_NAMEs: SCHWARTZ, ROBERT E (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;American;Applications Grants;Automobile Driving;Cardiovascular Diseases;Cell Communication;cell community;Cell Differentiation process;Cell Transplantation;cell type;Cells;Cellular Spheroids;Cessation of life;Clinical;clinical translation;Communities;Complex;Cues;Data;Development;differentiation in vitro;Disease;Dissection;Drug toxicity;Encapsulated;Engineering;experimental study;Extracellular Matrix;fetal;fetus cell;Generations;Goals;Hepatic;Hepatocyte;Hospitalization;Human;improved;In Vitro;in vivo;Incidence;Infection;insight;Liver;Liver diseases;liver transplantation;Maintenance;Mediating;Metabolism;Modeling;Organ;Organ Transplantation;Pathway interactions;Patients;Pharmacologic Substance;Phenotype;Play;pluripotent stem cell differentiation;Pluripotent Stem Cells;Process;PTK2 gene;Research;Role;Signal Pathway;Signal Transduction;Source;spheroids;src-Family Kinases;stem cell fate;stem cells;Stromal Cells;Supporting Cell;Testing;Tissue Engineering;tool;Transforming Growth Factor beta;Transplantation;United States;Work

PROJECT_TITLE: Optimization of the engineered 3D hepatic microenvironment enhances pluripotent stem cell derived hepatocyte

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: DAVIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Previous efforts at targeting human voltage-gated sodium channel subtype 1.7 (hNaV1.7) for the treatment of chronic pain have failed due to low therapeutic safety windows from lack of subtype selectivity. Creating peptides selectively targeting hNaV1.7 using a combination of validated computational design strategies is a promising solution. The experiments proposed will allow us to design a library of de novo peptides mimicking Protoxin-II, determine the residues critical for selective hNaV1.7 inhibition, and aid in the methodological and translational development of targeted therapeutics for chronic pain.

PI_NAMEs: HARRIS, BRANDON JOHN (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: academic preparation;Action Potentials;addiction liability;Adult;Affinity;American;Benchmarking;Binding;Biological Assay;Biological Products;Biological Response Modifier Therapy;Cardiac;career;Cells;Charge;chemical stability;chronic pain;chronic pain management;Clinical;clinical efficacy;Communication;Complex;Computational Science;Cryoelectron Microscopy;cytokine;Data;design;Development;Disulfides;drug candidate;Drug Design;drug discovery;effective therapy;Electrophysiology (science);experience;experimental study;Family;Genetic;Heart Arrest;Human;Human Genetics;Hydrophobicity;improved;Industry Collaboration;Integral Membrane Protein;Investigation;Ion Channel;Knowledge;knowledgebase;Learning;Libraries;Manuals;Methodology;Methods;mimetics;Modification;Mutagenesis;Mutate;nanomolar;Neurobiology;neuronal excitability;Neurosciences;Neurotoxins;Nociception;non-opioid analgesic;novel;Pain management;pain signal;Paralysed;patch clamp;Pathology;Peptides;peptidomimetics;Peripheral Nervous System;Peruvian;Pharmaceutical Preparations;Positioning Attribute;pre-clinical;prescription opioid;preservation;Protein Engineering;protein structure prediction;Proteins;Publishing;rational design;Research;Resolution;Safety;Scorpions;screening;Seizures;Side;skeletal;skills;small molecule;Sodium;Sodium Channel;Software Design;Spiders;structural imaging;Structure;targeted treatment;Testing;Therapeutic;thermostability;Time;Toxin;Training;Translational Research;Validation;validation studies;Variant;virtual screening;voltage;Work

PROJECT_TITLE: Design of de novo peptides and electrophysiological testing for voltage-gated sodium channel 1.7 inhibition related to chronic pain treatment


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative Polymerization of the protein actin into helical filaments and branched filament networks powers the directed motility of eukaryotic cells and some pathogenic bacteria. Cofilin and glial maturation factor (GMF) are two members of the actin depolymerization factor homology (ADF-H)-domain protein family that accelerate actin filament network reorganization and turnover through severing and debranching. The proposed studies will determine the structural basis of filament mechanical properties and severing by cofilin, and evaluate how filaments and branched filament networks respond to physical force.

PI_NAMEs: DE LA CRUZ, ENRIQUE M (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Acceleration;Actins;Biochemical;Biological Assay;biophysical techniques;Cell Physiology;cofilin;Complex;Cryoelectron Microscopy;Cytokinesis;depolymerization;Dissociation;Elasticity;Endocytosis;Eukaryotic Cell;Filament;genetic regulatory protein;Glia Maturation Factor;Magnetism;mechanical properties;Mechanics;member;Microfilaments;Microfluidics;Microscopic;Molecular Conformation;Motility;pathogenic bacteria;polymerization;Polymers;predictive modeling;Protein Family;Proteins;Tertiary Protein Structure;Work

PROJECT_TITLE: Actin filament mechanics and branched network turnover

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_DEPT: BIOLOGY

PHR: Project Narrative The proposed research is relevant to public health because it will characterize a novel form of immune defense against RNA virus infection in epithelial cells. By describing how the RIG-I-like receptor DRH-1 activates anti-viral defense in the nematode C. elegans, we may uncover novel forms of cell-intrinsic as well as systemic immune responses driven by epithelial cells. Thus, the proposed research is relevant to the NIH’s mission to seek fundamental knowledge about living systems in order to reduce the burden of disease.

PI_NAMEs: TROEMEL, EMILY R (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 2019-nCoV;Animals;Anti-viral Response;antiviral immunity;Behavior;Binding;Blood;burden of illness;C. elegans genome;Caenorhabditis elegans;candidate identification;cell type;Cells;cytosolic receptor;Data;Disease;Double-Stranded RNA;Epithelial Cells;Epithelium;fighting;Fluorescent in Situ Hybridization;France;Gene Expression;Genes;Genetic;genetic analysis;Genetic Transcription;Genomics;Goals;Health;helicase;Homologous Gene;Human;Immune;Immune response;in vivo;Infection;Inflammatory;Innate Immune Response;innovation;insight;Interferon Type I;Interferons;intestinal epithelium;Intestines;Ions;IRF3 gene;Knowledge;Mammals;Measures;Methods;Microscopy;Microsporidia;Mission;Modeling;Molecular;Mucous Membrane;Muscle;mutant;Names;Natural Immunity;Nematoda;Neurons;NF-kappa B;novel;Organism;Outcome;overexpression;pandemic disease;pathogen;pathogenic fungus;Pathway interactions;Pattern;Planets;Proteins;Proteomics;Public Health;receptor;Regulation;Reporter;Research;Resistance;response;RNA;RNA Interference;RNA Virus Infections;RNA Viruses;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Surface;System;Testing;Tissues;TNF gene;tool;transcriptomics;tripolyphosphate;United States National Institutes of Health;Up-Regulation;Viral;viral detection;Virus;Virus Diseases;Virus Replication;Visualization;Vulnerable Populations;Work;Zoonoses

PROJECT_TITLE: Innate immunity against viral infection in intestinal epithelial cells of C. elegans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-M(90)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Despite the development of effective antiretroviral therapies, HIV-associated neurocognitive disorders (HAND) remain prevalent but the underlying causes are complex and still poorly understood. We discovered that amyloid precursor protein (APP) restricts HIV-1 replication in brain-resident immune cells but in evading this restriction, HIV-1 accelerates APP processing into neurotoxic Aβ products. This proposal builds on new preliminary data that begin to reveal the underlying mechanisms of restriction by APP and the neurotoxic consequences of viral evasion strategies, and begins to explore the potential of inhibitors targeting APP processing as multifunctional therapeutics that simultaneously limit HIV-1 replication and neurotoxin production.

PI_NAMEs: NAGHAVI, MOJGAN HOSSEINI (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Affect;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid precursor protein processing;Amyloid Proteins;antiretroviral therapy;beta secretase;Brain;C-terminal;Cell Line;Cell membrane;cell type;Cells;Central Nervous System;Clinical;Coculture Techniques;Complex;Complex Mixtures;Conflict (Psychology);cytokine;Darkness;Data;Dementia;Development;Drug Design;Environment;Future;gag Gene Products;gamma secretase;Genetic;genetic approach;HIV-1;HIV-associated neurocognitive disorder;Human Amyloid Precursor Protein;human induced pluripotent stem cells;Immune;Infection;inhibitor;insight;Integral Membrane Protein;Integration Host Factors;Left;Light;Lysosomes;Macrophage;Mediating;Microglia;Modeling;Multivesicular Body;Nerve Degeneration;neurocognitive disorder;Neurodegenerative Disorders;Neurons;neuroprotection;neurotoxic;neurotoxicity;Neurotoxins;novel;Outcome;Pathway interactions;Patients;Persons;Play;preservation;prevent;Process;Production;protein aggregation;Protein C;Proteins;Proteolysis;Quality of life;Research;Research Proposals;Role;Sorting;T-Lymphocyte;Tail;Testing;Text;Therapeutic;Vacuolar Protein Sorting;Viral;Viral Physiology;Viral Proteins;Virion;Virus;Virus Assembly;Virus Replication;Work

PROJECT_TITLE: The interplay between HIV-1 and amyloid precursor protein in infection and neurotoxicity

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative There are many reasons why individuals afflicted by Alzheimer’s disease and related dementias (ADRD) would benefit from being diagnosed earlier. The goal of this research is to develop computer algorithms from data collected by financial bureaus to identify people who may be at risk for ADRD and who should receive clinical evaluation. Financial data is likely to be an important tool for helping with early diagnosis because people’s financial decisions are typically some of the first things affected by the disease.

PI_NAMEs: GRESENZ, CAROLE R (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Automobile Driving;Biological Markers;Brain imaging;Caring;Characteristics;comorbidity;Computational algorithm;cost;Data;Data Sources;Databases;Dementia;Diagnosis;diagnostic tool;digital;digital technology;Disease;Early Diagnosis;Early identification;Economics;Education;emerging adult;Enrollment;Equilibrium;Equity;Ethnic Origin;experience;Family;financial decision making;Gender;Goals;Habits;Health;Home;Household;Individual;Life Style;Liquid substance;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Medicare;Medicare claim;modifiable risk;Monitor;Moods;Neurobehavioral Manifestations;New York;Outcome;Outcome Measure;Patients;payment;Persons;Pharmaceutical Preparations;prediction algorithm;Predisposition;preference;Probability;Quality of life;Race;Research;research clinical testing;response;Risk;Risk Factors;Safety;Screening procedure;Signal Transduction;Signs and Symptoms;Social Security Number;Source;Structure;Support System;Symptoms;Time;tool;Update

PROJECT_TITLE: Using Digital Signals from Credit Data for Early Detection of Alzheimer's Disease and Related Dementias

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: Project Narrative The traditional view of the cerebellum as solely a motor control center has been revised in favor of a broader regulatory role, which includes limbic functions. These functions likely depend on the interaction between the cerebellum and key nodes in emotional circuits, such as the amygdala and nucleus accumbens; however, these interactions and their disruption in mental disorders are not understood. The central goal of this proposal is to dissect the connectivity between the cerebellum and the limbic system, using a combination of approaches that span levels of analysis, and to link the connectivity to learned behavior.

PI_NAMEs: FIORAVANTE, DIASYNOU  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Affective;Amygdaloid structure;Anatomy;Area;autism spectrum disorder;Behavior;Behavioral Genetics;Behavioral Paradigm;Brain;Calcium;Cell Nucleus;cell type;Cells;Cerebellum;Cognitive;Communication;Data;Dimensions;Disease;Dissection;Electrophysiology (science);Elements;Emotional;emotional behavior;entorhinal cortex;Experimental Genetics;experimental study;Extinction;Fiber;Fright;Generations;Goals;Habenula;Hippocampus;Image;Impairment;in vivo;in vivo calcium imaging;Individual;innovation;insight;Investigation;Knowledge;Lateral;learned behavior;Learning;learning extinction;Limbic System;Link;Maps;Measurement;Medial;Mediating;Memory;Mental disorders;Mental Health;metaplastic cell transformation;Molecular;Molecular Profiling;Monitor;motor control;motor learning;Movement;Mus;neural;Neurons;Nodal;novel;Nucleus Accumbens;optogenetics;patch sequencing;Pathway interactions;Photometry;Post-Traumatic Stress Disorders;Process;Property;Psyche structure;Reaction Time;Regulation;Reporting;Resolution;response;reward processing;Role;Signal Transduction;single cell sequencing;single-cell RNA sequencing;stem;Structure;Synapses;Testing;Thalamic structure;Time;transcriptomics;Ventral Tegmental Area;Viral;Well in self

PROJECT_TITLE: Multi-level dissection of cerebello-limbic connectivity

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Epigenetic alterations are a hallmark of aging and contribute to a variety of age-related diseases including cancer, neurodegeneration, and metabolic disorders. However, specific epigenetic modifications, such as an H3K4me3 deficiency, promote longevity and induce transgenerational benefits. This project will identify novel molecular mechanisms that govern these positive effects on aging and have the potential to be targeted to protect against the rapidly growing public health burden of age-related diseases.

PI_NAMEs: SILVA-GARCIA, CARLOS GIOVANNI (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Address;Age;age-related disease;Aging;aging process;aging related;Animals;Award;Binding;Caenorhabditis elegans;Capsid Proteins;career;Cell Aging;Cell Physiology;Cells;ChIP-seq;Chromatin;chromatin modification;Collaborations;Complement;Complex;CREB1 gene;Data;Down-Regulation;Endoplasmic Reticulum;Ensure;Enzymes;epigenetic aging;Epigenetic Process;epigenetic regulation;experimental study;extend lifespan;Fatty acid glycerol esters;Foundations;FRAP1 gene;Gene Expression;Gene Expression Profiling;Genetic;Genetic Transcription;Genomic approach;Germ Lines;Goals;Golgi Apparatus;hallmarks of aging;Histone H3;histone modification;HMGB1 gene;Homeostasis;Incidence;innovation;life span;Link;lipid metabolism;Longevity;Lysine;Malignant Neoplasms;Mammalian Cell;Mammals;Mediating;Mentors;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Methylation;Methyltransferase;Microscopy;Modeling;Modification;Molecular;Monounsaturated Fatty Acids;Nerve Degeneration;next generation;novel;Pathway interactions;Phase;Physiological;Post-Translational Protein Processing;Process;programs;protein complex;Proteins;Proteomics;Public Health;Publishing;Regulation;Research;Research Personnel;response;RNA Splicing;Role;Signal Transduction;spatiotemporal;success;System;Testing;Tissues;tool;trafficking;Training;Transcription Coactivator;transcription factor;Transcriptional Regulation;transgenerational epigenetic inheritance;Translating;transmission process;Universities;Vesicle;Vocational Guidance;Work

PROJECT_TITLE: Molecular mechanisms linking epigenetic changes to longevity

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases

ORG_DEPT: PSYCHIATRY

PHR: Program Narrative The proposed program is a collaborative partnership between the University of Nigeria (UNN) and University of California San Diego (UCSD) to strengthen UNN research administration and management infrastructure to manage HIV research funds. The program will build research capacity at UNN by: 1) understanding the needs and gaps in research administration and management at UNN; 2) improving the grants management and proposal development knowledge, skills, and proficiency of UNN research administrators and HIV implementation researchers; and 3) strengthening the ability of UNN research administrators and HIV implementation researchers to submit successful NIH, CDC, and other donor-funded HIV grant applications by providing mentorship, ongoing coaching and online courses from UCSD program instructors. The proposal will train and mentor 12 UNN trainees through hands-on workshops and mentorship programs, and teach dozens of trainees through online courses to meet the demand for grant funds accountability.

PI_NAMEs: AARONS, GREGORY  (contact);EZEANOLUE, ECHEZONA EDOZIE

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: 15 year old;Acceleration;Accountability;Acquired Immunodeficiency Syndrome;Address;Administrator;Adult;Africa South of the Sahara;AIDS prevention;Applications Grants;Award;Awareness;Biomedical Research;Budgets;California;Caring;Center for Translational Science Activities;Centers for Disease Control and Prevention (U.S.);Clinical Research;cohort;Collaborations;college;Country;COVID-19 pandemic;Development;Development Plans;Dissemination and Implementation;dissemination science;Educational Curriculum;Educational process of instructing;Educational workshop;Emergency Situation;Enrollment;Epidemic;Exercise;experience;Fogarty International Center;Funding;Funding Opportunities;Government Agencies;Grant;Guidelines;HIV;HIV Infections;implementation research;implementation science;improved;Infrastructure;infrastructure development;Institution;instructor;interest;International;Intervention;Interview;Investments;Knowledge;Learning;Life Cycle Stages;low and middle-income countries;male;Medicine;member;Mentors;Mentorship;Needs Assessment;Nigeria;Nigerian;online course;Persons;Policies;Preparation;Prevalence;Procedures;Process;professor;programs;Public Health;Research;Research Institute;Research Personnel;Research Project Grants;Research Proposals;research to practice;Research Training;Resources;response;Site Visit;skills;State Government;symposium;System;Time;Training;Training Programs;Training Support;Translational Research;Translations;United States;United States National Institutes of Health;Universities;virtual delivery;Visit;Women's prevalence;Work

PROJECT_TITLE: Strengthening Research Administration Infrastructure for HIV Research in Nigeria


ORG_CITY: TEMPE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Work proposed here will allow single molecule sequencing of glycosaminoglycan polysaccharides using an electronic chip with a high speed and low cost for the first time. Glycosaminoglycans have important pharmacological properties and are modulators of critical biological phenomena such as tissue development/regeneration and inflammation. Determination of their structures will allow better understanding of how organisms control these physiological events through glycosaminoglycans.

PI_NAMEs: WANG, XU  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 2019-nCoV;analytical method;Anticoagulants;Binding;Biological;Biological Markers;Biological Phenomena;Biopolymers;Biotin;Blood coagulation;Categories;Cells;Complex;cost;design;Development;Disease;DNA;DNA biosynthesis;DNA-Directed DNA Polymerase;Electric Conductivity;Electricity;Electrodes;Electronics;Engineering;enzyme activity;Enzymes;Event;Family;Foundations;Glycosaminoglycans;Goals;Grant;Growth and Development function;Heparin;Heparin Lyase;Heparitin Sulfate;Heterogeneity;improved;Inflammation;interest;Leukocyte Trafficking;Libraries;Ligands;Lyase;Machine Learning;Mammals;Measurement;Measures;Medicine;Methods;Microbe;Molecular Conformation;nanopore;Natural regeneration;novel;Organism;pathogenic bacteria;pathogenic virus;pharmacologic;Physiological;Play;Polymerase;Polymers;Polysaccharides;polysulfated glycosaminoglycan;Positioning Attribute;Process;Property;Proteins;receptor;Research Personnel;Resolution;Role;Sampling;Senile Plaques;sensor;Signal Transduction;Signaling Protein;single molecule;solid state;Speed;Streptavidin;Structure;Structure-Activity Relationship;Sulfate;Surface;Techniques;Technology;Therapeutic;Time;Tissues;Virus Diseases;Work

PROJECT_TITLE: Sequencing Glycosaminoglycans using Single Molecule Enzyme Conductance Fluctuations

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Newark

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative This project seeks to develop an alternative treatment method for xerostomia or dry mouth, a devastating side effect of radiation therapy that affects 68-85% of head and neck cancer patients. We will develop a bottom-up approach to recreate a functional salivary gland using patient-derived cells with regenerative potential and artificial extracellular matrices that recapitulate the native microenvironments of the developing organ. The goal is to produce an engineered construct with branched architecture consisting of secretory acini and connected ducts.

PI_NAMEs: JIA, XINQIAO  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: 3-Dimensional;Ablation;Acetylcholine;Acinar Cell;Acinus organ component;Affect;Alkenes;alternative treatment;analog;Animal Model;Architecture;Basement membrane;Beds;Biochemical;Biological Markers;biomaterial compatibility;Biomechanics;Biomedical Engineering;Blood Vessels;Body Weight decreased;Calcium;Cancer Patient;Carbachol;Cell Communication;Cell Differentiation process;Cell Lineage;Cell Polarity;Cells;Cellular Spheroids;Chemicals;Coculture Techniques;Complex;Cues;cycloaddition;Deglutition;Dental;Development;Duct (organ) structure;Ductal Epithelial Cell;Eating;Encapsulated;Endothelial Cells;Endothelium;Engineering;Environment;Epithelium;Exhibits;Extracellular Matrix;Fostering;Gel;Gene Expression Profile;Geometry;Gland;Goals;Growth;Growth Factor;Head and Neck Cancer;head and neck cancer patient;Heterogeneity;Homeostasis;Human;Human Engineering;hydrogel scaffold;Hydrogels;Immunocompetent;Implant;implantation;In Vitro;in vivo;innovation;interfacial;interstitial;Intraperitoneal Injections;Investigation;Ligation;Maintenance;Measures;mechanical signal;Mediating;Mesenchymal;Mesenchymal Stem Cells;Methods;mimetics;Morphogenesis;morphogens;Morphology;Motility;Myoepithelial cell;Natural regeneration;Nerve;nerve supply;neural;Neurons;Neurotransmitters;neurotrophic factor;neurturin;Nude Rats;Oral;Oral cavity;Organ;Outcome Measure;Parotid Gland;Patients;Peptide Hydrolases;Peptides;Phenotype;Pilocarpine;polarized cell;progenitor;Property;Proteomics;Quality of life;Radiation therapy;Rattus;Reaction;reconstitution;recruit;regeneration potential;Resected;response;restoration;Saliva;Salivary;Salivary duct structure;Salivary Gland Tissue;Salivary Glands;Sepharose;Shapes;side effect;Signal Transduction;spheroids;stem;stem cell biomarkers;stem cells;Structure;subcutaneous;Symptoms;Tissue Engineering;Tissue Expansion;Tissues;transcriptome;transcriptome sequencing;transplant model;Treatment Efficacy;treatment strategy;Trees;Vascularization;Work;Xerostomia

PROJECT_TITLE: Bottom-Up Assembly of Functional Salivary Gland Tissues

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative PD-1 immune checkpoint inhibition (ICI) in patients with cancer is associated with secondary immune-related adverse events (irAEs) that limit its use, especially for those patients with the higher-grade toxicities. PD-1 signaling is important for maintaining immune homeostasis but the exact mechanism through which PD-1 inhibition leads to autoimmunity is not understood. This proposal will test the hypothesis that de novo loss of PD- 1 signaling enhances the antigen sensitivity of CD4 T cells and leads to the activation of autoreactive CD4 T cells that mediate irAE development.

PI_NAMEs: APOSTOLIDIS, SOKRATIS  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Affect;analytical tool;anti-PD-1;anti-PD1 therapy;Antigens;Autoimmune;Autoimmune Diseases;autoimmune toxicity;Autoimmunity;autoreactivity;Bioinformatics;Blood;cancer immunotherapeutics;cancer therapy;career;career development;Caring;CD28 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;cellular targeting;checkpoint inhibition;Clinical;Clinical Research;Clonal Expansion;Clonality;cohort;Collaborations;collaborative environment;Communication;Data;design;Development;Development Plans;Dissection;Early Diagnosis;Early Intervention;Early treatment;Epigenetic Process;epigenetic regulation;Evaluation;Event;Exhibits;experience;Faculty;Feedback;fitness;Foundations;Functional disorder;Funding;Gene Expression Profile;Genetic Transcription;Goals;Grant;Growth;Helper-Inducer T-Lymphocyte;Homeostasis;Human;Immune;immune-related adverse events;Immunization;immunopathology;Immunotherapy;Impairment;Inflammatory;Influenza vaccination;influenza virus vaccine;Intervention;Malignant Neoplasms;Mediating;Medical;Memory;Mentors;Molecular Target;multimodality;novel;novel strategies;Oncology Group;Pathology;Pathway interactions;Patients;PD-1 pathway;Pennsylvania;permissiveness;Phase;Physicians;Population;Positioning Attribute;pre-clinical;Preparation;prevent;Prevention;Productivity;programmed cell death protein 1;programs;prospective;Proxy;recruit;Research;Research Personnel;Resolution;response;Rheumatism;Rheumatology;Sampling;Scientist;seasonal influenza;Shapes;Signal Transduction;single cell analysis;single cell technology;skills;Surface;systemic autoimmune disease;T cell response;T-Lymphocyte;tenure track;Testing;Time;Toxic effect;Training;Transcriptional Regulation;Translational Research;tumor;United States National Institutes of Health;Universities;Vaccination;Vaccines;Writing

PROJECT_TITLE: Single-cell dissection of CD4 T cell changes in patients with immune-related adverse events following PD-1 inhibition


NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases;Nutrition;Rare Diseases;Tuberculosis

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: A cadre of chaperones guide the intracellular journey of vitamin B12, an essential nutrient, to the two enzymes that use this cofactor in humans. Our laboratory has been at the vanguard of elucidating chaperone functions and unraveling the intricate chemical strategies for moving B12, which is both large and reactive. In the next cycle, we will illuminate how B12 is partitioned between the cytoplasmic and mitochondrial branches, loaded onto its client enzymes, and how these processes are compromised by disease-causing mutations.

PI_NAMEs: BANERJEE, RUMA V (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TITLE: B12 Trafficking and Inherited Defects

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Accurate diagnosis of rare genetic disorders facilitates prognosis, guides clinical treatment, clarifies risk prediction of other family members and informs reproductive decisions. This project will improve accuracy, throughput and effect communication about interpretation of the genetic variants causing rare genetic disorders.

PI_NAMEs: FAN, XIAO  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: accurate diagnosis;Alleles;American;autism spectrum disorder;Benign;biobank;Calibration;Cardiomyopathies;case control;Categories;Classification;Clinical;clinical database;clinical implementation;Clinical Treatment;clinically relevant;ClinVar;cohort;Communication;Computational Biology;computer science;Computing Methodologies;Confusion;cost;Data;Data Set;Databases;deep neural network;Diagnostic;Disease;DNA sequencing;exome;falls;Family member;Foundations;Future;Gene Frequency;Genes;genetic testing;genetic variant;Genome;Genomic medicine;genomic variation;Genomics;Goals;Guidelines;Health Personnel;Human;human disease;implementation facilitation;improved;in silico;Individual;Intuition;Knowledge;Label;Laboratories;Machine Learning;Measures;Medical;Medical Genetics;medical schools;Methods;Modeling;molecular pathology;Mutagenesis;neural network;Neural Network Simulation;next generation;next generation sequencing;non-genetic;novel;Operative Surgical Procedures;Parents;Pathogenicity;Patient Recruitments;Patients;Pediatric Cardiomyopathy;Population;Positioning Attribute;Postdoctoral Fellow;Probability;Prognosis;programs;prophylactic;protein structure;Provider;public database;Publishing;rare genetic disorder;Registries;reproductive;Research;risk prediction;screening;Standardization;supervised learning;Techniques;Test Result;Time;tool;Training;transfer learning;translational genomics;Variant;variant of unknown significance;Veterans;web based interface

PROJECT_TITLE: New quantitative approaches to interpret variant pathogenicity


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Suicide

ORG_CITY: PORTLAND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative This study will add to understanding of how environmental exposures combine with genetic liability in shaping the course of attention-deficit / hyperactivity disorder (ADHD). It will facilitate better understanding of influences on youth mental disorder, depression, drug use, and suicidality, which are all at increased risk in children who meet criteria for ADHD. If successful it will suggest better targets for modifiable causes and treatment or prevention.

PI_NAMEs: MOONEY, MICHAEL A (contact);NIGG, JOEL T

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Address;Adolescence;Adolescent;Age;Alcohol consumption;Anxiety Disorders;Area;Attention;Attention deficit hyperactivity disorder;Behavioral;Brain;case control;Characteristics;Child;Child Rearing;Childhood;Clinical;Code;Cognition;cohort;Conduct Disorder;conduct problem;Conflict (Psychology);Data Set;density;design;Development;Diagnosis;Dimensions;Disadvantaged;discounting;Disease;Drug usage;economic indicator;Education;emerging adult;emotion regulation;Emotional;Environment;Environmental Exposure;Environmental Risk Factor;Etiology;Evaluation;Evolution;executive function;Exposure to;Family;family burden;Family Characteristics;follow-up;frontier;Future;Genetic;Genetic Risk;Genotype;Heritability;Heterogeneity;Hyperactivity;Impulsivity;inattention;innovation;Intervention;Knowledge;lead exposure;Length;Maps;Measures;Mediating;Mediation;Mental Depression;Mental disorders;Methods;Modeling;Mood Disorders;National Institute of Mental Health;neighborhood disadvantage;Neighborhoods;Neurocognitive;neurodevelopment;Neuropsychology;novel;Oregon;Outcome;Parents;Phenotype;Pollution;polygenic risk score;Population;Prevention;Psychopathology;Rewards;Risk;Severities;Shapes;social disparities;socioeconomics;Structure;substance use;suicidal;suicidal risk;Symptoms;Testing;theories;Time;traffic-related air pollution;trait;Variant;vigilance;Waxes;Work;Youth

PROJECT_TITLE: Polygenic and environmental contributions to ADHD trajectory and outcome from childhood through adolescence

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Despite evidence that consistent treatment is important for effectively managing ADHD-related symptoms and impairments, ADHD treatment adherence remains suboptimal, especially among minority children. The proposed project will develop a novel, systematic intervention to improve ADHD treatment adherence for minority (Latinx and African American) children that will be delivered using a culturally-tailored family navigator approach. This intervention has the potential to improve developmental-behavioral outcomes for minority pediatric populations by addressing their barriers to consistent engagement with ADHD treatment.

PI_NAMEs: KAMIMURA-NISHIMURA, KELLY  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Advocacy;African American;Area;Attention deficit hyperactivity disorder;Behavior;Behavior Disorders;Behavior Therapy;Behavioral;Behavioral Model;behavioral outcome;Belief;career development;Caregivers;Child;Childhood;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Communities;community engaged research;community partnership;Data;design;Development;Development Plans;Developmental Disabilities;distrust;Elements;empowerment;Environment;ethnic disparity;Evidence based intervention;Evidence based treatment;experience;Faculty;Failure;Family;Feedback;Feeling;Focus Groups;Funding;Goals;Grant;Guidelines;health care disparity;health disparity;Health Personnel;Health Services Accessibility;Healthcare;Healthcare Systems;Impairment;Improve Access;improved;Intervention;K-Series Research Career Programs;Latinx;Latinx population;Link;Literature;Manuals;Manuscripts;medication compliance;medication nonadherence;member;Mental Health;Mental Health Services;Mentorship;Methodology;Minority;minority children;Minority Groups;Modeling;Modification;Motivation;motor vehicle injury;National Institute of Mental Health;navigator intervention;Neurodevelopmental Disorder;novel;Outcome;Parent-Child Relations;Parents;patient oriented;Pediatric Hospitals;pediatrician;Perception;Pharmaceutical Preparations;Phase;Population;Positioning Attribute;Productivity;Qualitative Methods;racial disparity;Randomized, Controlled Trials;Recommendation;Research;research clinical testing;Research Personnel;side effect;Source;Stimulant;Symptoms;Testing;therapy development;Training;treatment adherence;treatment as usual;treatment planning;Trust;Uncertainty;Underserved Population;United States National Institutes of Health;Work;Writing;Youth

PROJECT_TITLE: A Family Navigator Intervention to Improve ADHD- Related Treatment Adherence (I2-ART) for Minority Children

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This University of Minnesota program will provide training in cardiovascular disease epidemiology and prevention to 3 postdoctoral and 4 predoctoral (PhD) students. Trainees will learn how to formulate and conduct research to enhance understanding of the causes of cardiovascular disease and how to prevent them.

PI_NAMEs: LUTSEY, PAMELA L.;PANKOW, JAMES S (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TITLE: Cardiovascular Disease Epidemiology & Prevention

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM (OA)]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Increased pace of research in pharmaceutical and biotechnology-oriented industries, increased venture capital investment in biotech start-ups, new technological breakthroughs including CRSPR-based genome editing, RNA-based vaccines, advances in computational modeling, new cell-based and animal models of human disease, etc., all generate a demand for a diverse pool of broadly, interdisciplinary educated PhD level scientists. The Iowa Biotech Training Program will fulfill this need by training future leaders ready for successful careers in industry, academia, and governmental research.

PI_NAMEs: ARNOLD, MARK A.;SCHNIEDERS, MICHAEL JOHN;SPIES, MARIA  (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TITLE: Iowa Biotech-TP: Predoctoral Program in Biotechnology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE We seek continued funding support for training future scientists with MDs and/or PhDs (or equivalent) to develop transdisciplinary team science expertise in behavioral sciences for multimorbidity prevention and control, mechanisms of behavior change and disease, and population health equity and policy. These trainees will make discoveries during and after their training that will advance the science and practice of lifestyle behaviors and behavior change for the prevention and control of health conditions involving the heart, lung and/or blood.

PI_NAMEs: CASKEY, RACHEL ;MA, JUN  (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TITLE: Precision Lifestyle Medicine and Translation Research (PREMIER)


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Despite remarkable new treatments to treat heart, lung and blood diseases, many important questions remain regarding the benefits and risks of particular products and how these medicines can best be used to improve human health. We propose to renew an innovative and rigorous training program in pharmacoepidemiology, a bridge science that uses tools from pharmacology, epidemiology and clinical medicine to understand the use, safety and effectiveness of drugs in large populations. Our program will continue to train the next generation of scientists to address the needs of patients, clinicians, payers, regulators and other stakeholders, and in so doing, improve the optimal use of medicines to treat heart, lung and blood diseases in the United States.

PI_NAMEs: ALEXANDER, G. CALEB (contact);SEGAL, JODI B.

PROJECT_TERMS: National Heart, Lung, and Blood Institute;Pharmacoepidemiology;Training Programs

PROJECT_TITLE: NHLBI Training Program in Pharmacoepidemiology


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

PHR: Project Narrative This proposal is aimed at evaluating and defining nelfinavir, an FDA-approved and commonly used antiviral agent, as an immune-sensitizer for enhancing cell-based therapy against melanoma. This study may lay groundwork and provide rapid path to enter clinical trials of nelfinavir for treatment of patients with immune poor-responsive melanoma, an aberrantly aggressive and fatal disease.

PI_NAMEs: YANG, JIN-MING  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Address;Adoptive Cell Transfers;Affect;Anti-viral Agents;Antibodies;Biological Availability;calmodulin-dependent protein kinase III;CAR T cell therapy;CD8-Positive T-Lymphocytes;Cell Death;Cell Line;Cell Physiology;Cell Therapy;Cell-Mediated Cytolysis;Cellular Metabolic Process;Cessation of life;chemotherapy;Clinical Treatment;Clinical Trials;Coculture Techniques;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;cytotoxicity;Disease;EEF2 gene;Effectiveness;Excision;Family;fatty acid oxidation;FDA approved;feasibility testing;Glycolysis;Goals;HIV;HIV/AIDS;HLA-A2 Antigen;Human;Immune;Immunologics;Immunotherapy;improved;In Vitro;in vivo;Malignant Neoplasms;Measures;Mediating;Melanoma;Melanoma Cell;Messenger RNA;Metastatic Melanoma;Modeling;Monitor;Movement;Mus;Mutation;Nelfinavir;Neoplasms;neoplastic cell;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Oral;overexpression;patient prognosis;Patients;PDL1 inhibitors;Peptides;pharmacologic;Phosphorylation;Phosphotransferases;Pluripotent Stem Cells;programmed cell death protein 1;Protein Biosynthesis;Proteins;Reaction;response;Retroviral Vector;Ribosomes;Role;Site;Skin Cancer;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutically effective;therapy outcome;Translations;treatment strategy;tumor;Tumor Immunity;tumor progression;Tumor Promotion;Virus;Virus Diseases

PROJECT_TITLE: Novel Strategy to Augmenting Immunotherapy against Melanoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (O2)]


ORG_DEPT: ORTHOPEDICS

PHR: Project Narrative This application aims to engineer a novel tendon specific microphysiological system to understand how loss of extracellular matrix stiffness increases inflammatory signaling in tendinopathy. Knowledge gained from these studies will inform development of therapeutic targets to treat tendon disease.

PI_NAMEs: ABRAHAM, ADAM CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;Address;Animal Model;Automobile Driving;B-Cell Activation;cantilever;cell behavior;Cell Culture Techniques;Cells;Chemicals;Chronic;Clinical Treatment;Collagen;Consult;Coupling;cytokine;Cytokine Receptors;Development;Disease;Engineering;Enhancers;Environment;Exhibits;Exposure to;Extracellular Matrix;Fibroblasts;Gene Expression;Genes;Goals;healing;Human;IL1R1 gene;improved;In Situ;in vivo;Inflammation;Inflammatory;Inflammatory Response;insight;Interleukin-1 beta;Investigation;Knowledge;Light;Measures;mechanical properties;Mechanics;Membrane;microphysiology system;Molecular;Musculoskeletal Diseases;NF-kappa B;novel;novel strategies;novel therapeutics;Nuclear;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patient Care;patient population;Patients;Phenotype;polymerization;Polymers;Primary Care;Property;Publishing;receptor;Regulation;Reporter;Research;Risk;Role;Signal Transduction;Stimulant;Tendinopathy;Tendon structure;Therapeutic;therapeutic development;therapeutic target;tissue culture;Tissues;Transfection;Translations;Tumor Necrosis Factor Receptor;Visualization;Work

PROJECT_TITLE: Extracellular Matrix Regulation of Inflammatory Signaling in Tendon

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Suicide

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Bipolar I disorder diagnoses is the highest risk factors for suicide death, especially in older men. Here, we will use brain tissue samples from postmortem donor samples and perform RNA-sequencing to identify the molecular and cellular brain abnormalities in bipolar disorder suicide deaths across aging and sex. Our findings will contribute to better mechanistic understanding of brain biological changes associated with suicide risk, facilitate biomarker discovery, and guide the development of novel treatment targets for suicidal states.

PI_NAMEs: JABBI, MBEMBA  (contact);WALSS-BASS, CONSUELO

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: Adult;Affect;Age;Aging;aging related;Anatomy;Anterior;Automobile Driving;Autopsy;Biological;biomarker discovery;Bipolar Disorder;Bipolar I;Brain;brain abnormalities;brain cell;brain circuitry;Brain region;brain tissue;brain volume;Cause of Death;Cell Nucleus;cell type;Cessation of life;cohort;Collection;Complex;Data;Death Rate;depressive symptoms;Development;Diagnosis;Disease;Down-Regulation;early onset;Emotions;Exhibits;experience;Feeling suicidal;Female;Future;Gene Expression;Gene Expression Profile;General Population;Goals;gray matter;Heritability;High Prevalence;high risk;Human;Image;imaging study;Immunologic Markers;Individual;individual patient;Inflammatory;inflammatory marker;innovation;Insula of Reil;Intervention;Knowledge;life span;Link;Magnetic Resonance Imaging;maladaptive behavior;male;Measures;Mental Health;Microglia;Modeling;Molecular;Molecular Abnormality;Molecular Biology;molecular marker;Molecular Profiling;Monitor;Mood Disorders;Moods;Morbidity - disease rate;Multiple Endocrine Neoplasia Type 1;National Institute of Mental Health;neurobiological mechanism;Neurons;novel;novel marker;novel therapeutic intervention;older men;Outcome;Patients;Persons;Phenotype;Positron-Emission Tomography;Prevention;Process;Public Health;Recording of previous events;Risk;Risk Factors;RNA;Sampling;sex;Sexual Dysfunction;Signal Transduction;single nucleus RNA-sequencing;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide rate;Symptoms;Testing;Tissue Sample;Tissues;transcriptome sequencing;transcriptomics;United States;Woman;Work

PROJECT_TITLE: Brain network and cell-type elucidation of molecular dysregulations in bipolar disorder suicide

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROGRAM PROJECT GRANT OVERALL NARRATIVE This collaborative research effort will define host, bacterial, and dietary factors important in the development of gastric cancer. This information will then be used to identify and treat H. pylori-infected persons at increased risk for this disease.

PI_NAMEs: PEEK, RICHARD M. (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Academic Medical Centers;Address;Affect;anti-cancer research;Attenuated;Basic Science;Bile Acids;Bioinformatics;Biological Models;Cancer Burden;Cancer Etiology;cancer risk;carcinogenesis;carcinogenicity;Carcinogens;Cells;Cessation of life;Characteristics;Clinical;clinical material;co-infection;colitis associated cancer;Collaborations;Colombia;complement system;Core Facility;Dedications;deprivation;Development;Diet;dietary;Dietary Factors;digital;Disease;disorder risk;Disparity population;DL-alpha-Difluoromethylornithine;effective therapy;Engraftment;Environment;Environmental Exposure;Epidermal Growth Factor Receptor;Etiology;Evaluation;Funding;Funding Mechanisms;Gastric Adenocarcinoma;gastric carcinogenesis;Gastric mucosa;gastric organoids;Gastric Tissue;Gastroenterology;Genomics;Goals;Harvest;Helicobacter Infections;Helicobacter pylori;Helicobacter pylori induced gastric cancer;Helicobacter Pylori-Related Malignant Neoplasm;high salt diet;Histology;Histopathology;Human;Immune response;Immunobiology;Immunofluorescence Immunologic;Immunohistochemistry;improved;Individual;Infectious Agent;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;International;Intervention;Investigation;Investments;Iron;iron deficiency;Laboratories;Lesion;Link;lipidomics;Malignant neoplasm of esophagus;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;malignant stomach neoplasm;Mediator;metabolomics;microbial;Microbiology;molecular imaging;Mucositis;Mus;Mutation;new therapeutic target;novel;novel strategies;novel therapeutics;Oncogenic;Oncoproteins;Ornithine Decarboxylase;pathogen;Pathogenicity;Pathologic;Pathway interactions;personalized medicine;Persons;pharmacologic;polyamine oxidase;Polyamines;Positioning Attribute;premalignant;Prevention;Prevention approach;priority pathogen;Program Research Project Grants;programs;prospective;Prospective cohort;Proteomics;Reagent;Recommendation;recruit;Regulation;Research;Research Activity;Research Personnel;Resources;response;Risk;Risk Factors;Rodent Model;Sampling;Science;Services;Signal Pathway;Signal Transduction;square foot;statistics;stem cell population;Stomach;System;Technology;Tissue Microarray;transcriptomics;Translating;Type IV Secretion System Pathway;Variant;Virulence;Work;working group

PROJECT_TITLE: H. pylori-induced Inflammation and Gastric Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-T (O1)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Infectious Diseases;Nutrition;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stomach Cancer

PHR: PPG PROJECT 1 NARRATIVE These collaborative studies will define bacterial and host factors that influence gastric cancer within the context of iron deficiency. Such findings will help to identify H. pylori-infected persons at high risk for gastric cancer, who thereby warrant therapy.

PROJECT_TERMS: Acceleration;Acids;Address;beta catenin;Bile Acids;Bile Reflux;Biological Models;Cancer Etiology;cancer risk;carcinogenesis;carcinogenicity;Cells;Cessation of life;chemokine;Clinical;cohort;Colombia;Data;Deoxycholic Acid;Deposition;deprivation;Development;Diet;Dietary Factors;differential expression;Disease;disorder risk;Endowment;Epidermal Growth Factor Receptor;Epithelial Cell Proliferation;Epithelial Cells;epithelial stem cell;Epithelium;experimental study;Female;follow-up;Freezing;Gastric Adenocarcinoma;gastric carcinogenesis;Gastric Intraepithelial Neoplasia;Gastric mucosa;gastric organoids;Gastric Tissue;Gastrointestinal tract structure;Gerbils;Helicobacter Infections;Helicobacter pylori;Helicobacter pylori induced carcinogenesis;Helicobacter Pylori-Related Malignant Neoplasm;high risk;Hispanic;Histologic;Human;Immunoglobulin Domain;in vivo;Incidence;Inflammation;Inflammatory;Inflammatory Response;innovation;INS gene;Integration Host Factors;Intervention Studies;Iron;iron deficiency;Knowledge;Lesion;Leucine-Rich Repeat;male;Malignant Neoplasms;malignant stomach neoplasm;Mediating;metabolomics;microbial;Modeling;Mus;Neoplasms;Oncogenic;Oncoproteins;Pathogenicity;Persons;Phenotype;Population;Predisposition;premalignant;Proliferating;prospective;Prospective cohort;Receptor Activation;Resources;Risk;Risk Factors;Signal Transduction;stem cell homeostasis;stem cell niche;stem cell population;stem cells;Stomach;System;Testing;Tissue Microarray;Transgenic Organisms;Type IV Secretion System Pathway;United States;Validation;Virulence;Work

PROJECT_TITLE: Effect of Iron Deprivation on H. pylori-induced Gastric Carcinogenesis


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Prevention;Rare Diseases;Stomach Cancer

PHR: PROJECT 2 – NARRATIVE Helicobacter pylori is a type of bacteria that infects the stomach of half of the world’s human population, and is the main cause of stomach cancer, the fourth leading cause of cancer death worldwide. Benefiting from synergistic interactions with the other projects and highly developed research cores of this Program Project Grant, we will utilize specialized cell and animal model systems and a wide variety of existing human tissue samples including patients at all stages of disease from inflammation of the stomach to cancer and from patients with disease progression, to assess novel molecular pathways altered by H. pylori that lead to poorly controlled stomach damage and ultimately, the development of cancer. Our mechanistic studies are expected to allow us to reach our long-term goal of establish new targeted strategies for prevention and treatment of gastric cancer.

PI_NAMEs: WILSON, KEITH T. (contact)

PROJECT_TERMS: Acrolein;Address;adduct;Aldehydes;analog;Animal Model;Antibiotics;Award;Back;Bacteria;Biological Models;Biotechnology;Buckwheat;Cancer cell line;Cancer Etiology;cancer prevention;Cancer Prevention Intervention;cancer risk;cancer therapy;Cancerous;carcinogenesis;Carcinogenesis Mechanism;carcinogenicity;Cell model;Cells;Cessation of life;Chronic;Clinical;Clinical Trials;cohort;Colombian;Cysteine;Data;Development;Disease;Disease Progression;DNA;DNA Damage;driving force;Ensure;Epigenetic Process;Epithelial Cells;Epithelium;Event;Exhibits;Functional disorder;Gastric Adenocarcinoma;gastric cancer cell;gastric cancer prevention;gastric carcinogenesis;gastric organoids;Gastric Tissue;Gastritis;Generations;Genomic Instability;Genomics;Gerbils;Goals;Half-Life;Helicobacter Infections;Helicobacter pylori;Helicobacter pylori induced carcinogenesis;Helicobacter Pylori-Related Malignant Neoplasm;Histologic;Human;human tissue;Hydrogen Peroxide;Immigration;Immune;Immunodeficient Mouse;immunoregulation;in vivo;infected vector rodent;Infection;Inflammation;inhibitor;insight;Intervention;Lead;Lesion;Link;Lipid Peroxidation;macromolecule;Malignant Neoplasms;malignant stomach neoplasm;Malondialdehyde;Mediating;Metabolism;metabolomics;Molecular;Mus;Natural Products;novel;novel strategies;Nude Mice;Oncogenic;Oxidants;oxidative damage;Pathway interactions;Patients;Persons;Phase I Clinical Trials;polyamine oxidase;Polyamines;Population;prevent;Prevention strategy;Program Research Project Grants;Proteins;Proteome;Reaction;Reactive Oxygen Species;Reporting;Research;Risk Factors;risk stratification;Role;Safety;Signal Transduction;Spermidine;Spermine;Stomach;Stomach Neoplasms;therapeutic target;Tissue Microarray;Tissue Sample;transcriptome;transcriptomics;Translating;tumor growth;tumor progression;tumor xenograft;Xenograft procedure

PROJECT_TITLE: Polyamines and Electrophiles in Gastric Cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Infectious Diseases;Nutrition;Prevention;Rare Diseases;Stomach Cancer

PHR: PPG PROJECT 3 NARRATIVE This research seeks to understand how a bacterial infection can lead to the development of stomach cancer and how the risk of stomach cancer is modified by composition of the diet. These results should help identify persons at high risk for gastric cancer, who can then be treated in order to prevent this disease.

PI_NAMEs: COVER, TIMOTHY L (contact)

PROJECT_TERMS: Amino Acid Substitution;Animal Model;Atrophic Gastritis;Bacterial Antibiotic Resistance;Bacterial Infections;biomarker identification;Biometry;Biopsy;Cancer Etiology;cancer risk;carcinogenicity;Carcinogens;Cessation of life;Characteristics;Chronic;Classification;cohort;Collaborations;Colombian;Data;Development;Diet;dietary;Dietary Factors;Dietary History;Dietary Iron;dietary salt;Disease;Dysplasia;Environment;Environmental Risk Factor;Evolution;Exhibits;Experimental Animal Model;experimental study;fitness;Gastric Adenocarcinoma;gastric cancer prevention;gastric carcinogenesis;gastric organoids;Gastric Tissue;Gastritis;Gene Expression;Genes;Genetic;genetic regulatory protein;Genetic Variation;Gerbils;Goals;Gram-Negative Bacteria;Health;Helicobacter Infections;Helicobacter pylori;high risk;high salt diet;Histologic;Histology;Histopathology;Homeostasis;Human;improved;In Vitro;in vivo;Incidence;Individual;Infection;Inflammation;innovation;Intestinal Metaplasia;Iron;iron deficiency;Lead;Link;Lipids;Malignant Neoplasms;malignant stomach neoplasm;mass spectrometric imaging;metabolomics;Metal Binding Site;Methods;Modeling;Molecular;molecular marker;Mutation;neoplastic;Oncogenic;Organoids;Pathology;Patients;Peptic Ulcer;persistent bacteria;Persons;Physiology;Population;Precancerous Conditions;premalignant;prevent;Prevention;Proteins;Proteomics;Regulation;Research;Risk;Risk Factors;Sodium Chloride;Stomach;System;targeted treatment;Testing;Therapeutic Intervention;Time;Tissue Microarray;Type IV Secretion System Pathway;Variant;Virulence;Work;World Health Organization

PROJECT_TITLE: Regulation of Helicobacter pylori virulence by dietary factors that impact gastric cancer


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Infectious Diseases;Rare Diseases;Stomach Cancer

PHR: PPG ADMINISTRATIVE CORE C NARRATIVE Administrative Core C will facilitate all of the activities required to collaboratively identify bacterial, host, and dietary factors that influence gastric carcinogenesis.

PROJECT_TERMS: Administrative Personnel;Biometry;Budgets;Calendar;Communicable Diseases;Communication;Data;data sharing;Dedications;Dietary Factors;Digestive System Disorders;Ensure;Feedback;Financial Activity;Funding;Future;gastric carcinogenesis;Gastroenterology;Generations;Goals;Helicobacter pylori;Home Page;Human Resources;Immune response;Immunology;Individual;Infection;Inflammation;Institution;Integration Host Factors;large datasets;Leadership;Link;malignant stomach neoplasm;Mass Spectrum Analysis;meetings;member;Microbiology;Modeling;Monitor;National Cancer Institute;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;Participant;Pathogenicity;Pathology;Principal Investigator;Productivity;Program Research Project Grants;programs;Progress Reports;Publications;Qi;Reporting;Research;Research Personnel;Resource Sharing;Resources;Schedule;Secure;Services;Site;System;Technology;United States National Institutes of Health;Update;web site;web-enabled

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Infectious Diseases;Rare Diseases;Stomach Cancer

PHR: CORE A NARRATIVE The work in this Core will help identify factors important in the development of gastric cancer. This may help identify persons at high risk for gastric cancer who can then be tested and treated for H. pylori. In addition, work performed in this Core may help find new treatment options to reduce the risk of developing gastric cancer.

PI_NAMEs: PIAZUELO, MARIA BLANCA (contact)

PROJECT_TERMS: Academic Medical Centers;Achievement;Animal Model;Archives;Attention;Cancer Center;Clinical;Collaborations;Cooperative Human Tissue Network;cost effective;Custom;Dedications;Development;Digestive System Disorders;digital;Enzymes;Equipment;Evaluation;experience;Fee-for-Service Plans;gastric carcinogenesis;Gastric Tissue;Gastritis;gastrointestinal;Gastrointestinal Diseases;Goals;Grant;Helicobacter pylori;high risk;high standard;Histologic;histological studies;Histology;Histopathology;Human;human disease;human tissue;Immune response;Immunofluorescence Immunologic;Immunohistochemistry;infected vector rodent;Inflammation;interest;Intestinal Cancer;Intestinal Metaplasia;Laboratories;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;malignant stomach neoplasm;mass spectrometric imaging;metabolomics;Mission;Modeling;Morphology;Neoplasms;new therapeutic target;Operative Surgical Procedures;Outcome;Pathogenicity;Pathologic;Pathologist;Pathology;Persons;Play;Program Research Project Grants;Proteins;Proteomics;quality assurance;Reproduction spores;Research;Resource Sharing;Resources;Risk Reduction;Rodent Model;Role;Services;Specimen;Stomach;Supervision;Testing;The Vanderbilt-Ingram Cancer Center at the Vanderbilt University;Tissue Microarray;Tissue Sample;Tissue Stains;Tissues;Translating;Washington;Work

PROJECT_TITLE: Gastric Histopathology