NIH_SPENDING_CATS: Aging;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Public Health Relevance Statement: A proper model system is crucial to advance the studies of human neuropsychiatric diseases. The proposed project will contribute to the research in this field by making critical resource available to neuroscience research community.

PI_NAMEs: WANG, XIAOQIN  (contact)

PROGRAM_OFFICER_NAME: LIU, CHRISTINA HUANG

PROJECT_TERMS: Acceleration;Address;Air;Animals;Area;Automobile Driving;Biological Models;Brain Diseases;Breeding;California;Callithrix;Callithrix jacchus jacchus;cognitive function;Colorado;Communities;cost;Country;design;experience;forging;Fostering;Funding;genetic manipulation;Genetic Variation;Growth;Human;improved;Institution;Investments;Japan;Laboratories;meetings;Modeling;Molecular;Nervous System Disorder;neuropsychiatric disorder;Neurosciences;Neurosciences Research;Paper;Population;Principal Investigator;Production;programs;public health relevance;Request for Applications;Research;Research Personnel;Resources;Scientific Inquiry;Surveys;System;technique development;Techniques;Transportation;United States;Universities

PROJECT_TITLE: Bicoastal Marmoset Breeding Center


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Alzheimer’s disease is a progressive neurodegenerative disorder without an effective cure. Neuronal activity disruptions contribute to Alzheimer’s disease etiology and its progression. We will investigate whether macroglia play a causal role in circuit disruptions and the overall disease process.

PI_NAMEs: KASTANENKA, KSENIA V. (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Adopted;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloidosis;Astrocytes;Autopsy;behavior measurement;Brain;brain tissue;Calcium;Cells;Chronic;Clinical Trials;cognitive load;Coupling;Data;Dementia;dementia burden;Deposition;Development;Disease;Disease Progression;Electrodes;Electrophysiology (science);Elements;Etiology;Exhibits;Failure;Fourier Transform;Functional disorder;gamma-Aminobutyric Acid;Glutamate-Ammonia Ligase;Glutamates;Glutaminase;Glutamine;Goals;Health;High Pressure Liquid Chromatography;Homeostasis;Hyperactivity;Image;Impaired cognition;in vivo calcium imaging;Individual;interest;macroglia;memory consolidation;Memory impairment;Metabolic;Molecular;molecular marker;mouse model;multiphoton microscopy;Mus;network dysfunction;Neurodegenerative Disorders;Neuroglia;neuronal circuitry;Neurons;neuropathology;Neurosciences;neurotransmission;non rapid eye movement;novel;novel therapeutic intervention;optogenetics;Pattern;Play;Population;Process;Proteins;Regulation;Reporting;restoration;Rodent;Rodent Model;Role;Senile Plaques;Sleep;Testing;Therapeutic;therapeutic development;tool;Transgenic Mice;voltage sensitive dye;Work

PROJECT_TITLE: Elucidating circuit disruptions in Alzheimer's disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: RELEVANCE / PROJECT NARRATIVE  Given the critical roles of Siglec-glycan ligand interactions in immunoregulation, a deeper understanding of these processes may aid the development of new therapeutic modalities. These modalities can be used to ameliorate inflammatory syndromes (such as those associated with COVID-19 infection) by inducing the inhibitory functions of Siglecs or be used to augment anti-tumor immunity by suppressing Siglec’s inhibitory actions. Such modalities may be combined with FDA-approved therapeutic agents, such as anti-PD-1 based immune checkpoint inhibitors, to achieve better response rates.

PI_NAMEs: WU, PENG  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: 2019-nCoV;Advanced Malignant Neoplasm;Affinity;anti-cancer;Anti-Inflammatory Agents;anti-PD-1;Binding;Binding Proteins;Biochemical;Cancer Patient;cancer therapy;cancer type;Cell Communication;Cell Death Induction;cell killing;Cell Line;Cell surface;Cells;Clinical;Clinical Trials;CTLA4 gene;cytotoxic;cytotoxicity;design;Development;Elements;Endowment;Engineering;Epitopes;Family;FDA approved;Genetic;glycosylation;Goals;Immune;immune activation;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune signaling;Immune system;Immunoglobulins;immunological synapse;immunoregulation;Immunotherapy;Inflammation;Inflammatory;invention;Lectin;Ligand Binding;Ligands;Macrophage;Malignant Neoplasms;mast cell;Mediating;Membrane Glycoproteins;Modality;Molecular;Myeloid Cells;nanoparticle;Natural Killer Cells;neoplastic cell;novel therapeutics;Pathology;Patients;Pattern;Polysaccharides;Process;programmed cell death protein 1;Proteins;receptor;Receptor Activation;receptor binding;recruit;Regulation;Relapse;Reporter;response;restraint;Role;SARS-CoV-2 infection;segregation;sialic acid binding Ig-like lectin;Sialic Acids;sialylation;Side;Signal Transduction;Syndrome;T-Lymphocyte;Testing;Therapeutic;Therapeutic Agents;tool;Toxic effect;tumor;Tumor Immunity;Tyrosine;Virus Diseases;Xenograft Model

PROJECT_TITLE: Exploring Siglec-glycan ligand interactions using chemoenzymatic approaches

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Cost Effectiveness Research;Emerging Infectious Diseases;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Strains of gonorrhea have developed resistance to all previously-used antibiotics. In this context, surveillance systems are essential to respond effectively and in a timely manner to the emergence of resistance. The proposed research will help us identify cost-effective strategies to enhance the surveillance of drug-resistant gonorrhea in the United States with the objectives of increasing the success rate of first-line treatments and extending the effective lifespan of antibiotics.

PI_NAMEs: YAESOUBI, REZA  (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Address;Anatomy;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Area;Behavior;Case Study;Centers for Disease Control and Prevention (U.S.);Cities;Clinic;Clinical;combat;Computer Simulation;cost;cost effective;cost effectiveness;cost estimate;cost per quality-adjusted life year;cost-effectiveness evaluation;Data;Diagnosis;Disease;drug testing;drug-resistant gonorrhea;economic evaluation;Ensure;Evolution;Geographic Locations;Goals;Gonorrhea;Guidelines;health economics;High Prevalence;HIV;Incidence;Individual;Infection;Investigation;life span;Mathematics;Measures;men;men who have sex with men;Methods;metropolitan;Modeling;models and simulation;Monitor;Names;Neisseria gonorrhoeae;Outcome;Performance;Pharmaceutical Preparations;Pharyngeal structure;Policy Maker;Population;Predisposition;premature;Prevalence;Public Health;Recommendation;Rectum;Research;Resistance;Resistance development;Resources;Risk;Sampling;Science;Sentinel Surveillance;sex;Sexually Transmitted Diseases;Site;Specific qualifier value;Specimen;success;surveillance network;surveillance strategy;Surveys;System;Testing;tool;transmission process;trend;United States;Urethra;Woman;World Health Organization

PROJECT_TITLE: Enhancing surveillance systems to slow the spread of antimicrobial-resistant gonorrhea in the United States

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: NEW ENGLAND COLLEGE OF OPTOMETRY

PHR: Project Narrative The goals of the short term research training program at NECO are to introduce optometry students to all aspects of vision research and to provide opportunities for participation in rigorous research. We aim to train the students in strong experimental design and execution. Based on previous experience we know that some of these students will further their training by pursuing a Master’s degree in vision science in addition to the OD degree, and some will choose a career in academia or research.

PI_NAMEs: PANORGIAS, ATHANASIOS  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: career;Career Choice;Circadian Rhythms;clinical practice;college;doctoral student;Eligibility Determination;Ethics;experience;Exposure to;Eye;Faculty;Funding;Future;Goals;Growth;Laboratories;laboratory experiment;Learning;light effects;Master of Science;member;Mentors;Myopia;New England;Optometrist;Optometry;Oral;Patient Care;Performance;pre-doctoral;programs;Recommendation;Records;Research;Research Personnel;Research Project Grants;Research Training;Review Literature;Running;Science;Scientist;Source;Statistical Data Interpretation;Students;Training;Training Programs;Translating;United States National Institutes of Health;Visual impairment;Writing

PROJECT_TITLE: Short-term research training at New England College of Optometry


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The field of muscle cell biology muscular dystrophy translational research is expanding as academic and industry partnerships are yielding new potential treatments that are undergoing assessment in the clinics. Well-trained and highly motivated investigators in this field are essential for the progress of basic and translational muscle cell research as there have been major breakthroughs in mechanisms of disease and the emergence of new potential therapies for muscle disease. Trainees of the Muscle Cell Biology, Pathophysiology, and Therapeutics Program will fulfill its stated mission by advancing to positions of leadership in academia or industry and continuing to uncover basic principles in mechanisms of disease while also developing next-generation therapies based in muscle diseases for the betterment of patients and their families.

PI_NAMEs: CROSBIE, RACHELLE HOPE (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Cellular biology;Functional disorder;Muscle Cells;Therapeutic


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE  The proposed training program is relevant to public health since providing short-term summer research training for medical students with an interest in ophthalmology will promote development of the next generation of ophthalmology physician scientists, who will make future research breakthroughs for treatment of eye diseases. The proposed research is thus also directly relevant to the National Eye Institute’s mission of supporting research training programs with respect to blinding eye diseases.

PI_NAMEs: BHATWADEKAR, ASHAY D (contact);LIND, JOHN THOMPSON

PROJECT_TERMS: Area;Basic Science;career;Childhood;Clinical;Clinical Research;clinical training;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Evaluation;experience;Experimental Designs;Exposure to;Faculty;faculty research;Glaucoma;Goals;Indiana;Infrastructure;innovation;interest;lectures;Literature;Medical Research;medical schools;medical specialties;Medical Students;Mentors;Methods;next generation;Ophthalmology;Optometry;Physicians;programs;Recruitment Activity;Research;Research Personnel;Research Project Grants;responsible research conduct;Retina;Scholarship;Schools;Scientist;Students;summer research;Time;Training;Translational Research;Underrepresented Populations;Underrepresented Students;Universities;videoconference;vision science

PROJECT_TITLE: Short-Term Training in Ophthalmology Research for Medical Students


NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Project Narrative Glaucoma is a leading cause of irreversible vision loss affecting 60 million people world-wide, however no effective primary prevention or treatment therapies exist for this blinding disease. While large-scale human genetic association studies have uncovered multiple genetic risk factors for glaucoma, the implicated genes and pathways are largely unknown. The goals of the proposed research are to characterize gene expression and its genetic regulation in glaucoma-relevant tissues from healthy human eyes, and to use this information together with human genetics studies to discover novel biological processes and pathogenic mechanisms for high- and normal-tension glaucoma.

PI_NAMEs: SEGRE, AYELLET VERED (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Affect;Alleles;Alternative Splicing;ATAC-seq;Autopsy;Biological;Biological Process;Blindness;causal variant;Cell Death;cell type;Cells;Chromatin;Ciliary Body;Complex;Computing Methodologies;Data;data integration;Disease;Disease susceptibility;disorder risk;DNA;DNA sequencing;Drug Targeting;Etiology;Eye;Eye diseases;Functional disorder;functional genomics;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene expression variation;Gene set enrichment analysis;gene-targeted therapy;Genes;Genetic;genetic association;genetic risk factor;Genetic study;Genetic Transcription;genetic variant;genome sequencing;genome wide association study;genomic locus;Genomic Segment;Genomics;Genotype;Genotype-Tissue Expression Project;Glaucoma;Goals;Heritability;Human;Human Genetics;improved;insight;Investigation;Link;Linkage Disequilibrium;macula;Maps;Measures;Methods;Molecular;Nerve Degeneration;new therapeutic target;novel;novel therapeutics;Optic Nerve;optic nerve disorder;Pathogenicity;Pathway interactions;Patients;Persons;Physiologic Intraocular Pressure;Predisposition;Prevention;Primary Open Angle Glaucoma;Primary Prevention;Protein Isoforms;Quantitative Trait Loci;Regulation;Research;Resources;Retina;Retinal Degeneration;Retinal Ganglion Cells;Risk;Risk Factors;sharing platform;single-cell RNA sequencing;Statistical Data Interpretation;Statistical Methods;statistics;Structure of sinus venosus of sclera;Systems Biology;Testing;Therapeutic;therapeutic development;therapy design;Tissue Sample;Tissues;Trabecular meshwork structure;trait;transcriptome;transcriptome sequencing;Translating;Untranslated RNA;Variant;Visualization;web platform;web site;whole genome;Work

PROJECT_TITLE: Uncovering novel biological processes and pathogenic mechanisms for glaucoma

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: Project Narrative The proposed research is relevant to public health because it will identify distinct molecular and neural mechanisms underlying dysfunction in the host-microbiota interaction that results from gut dysbiosis in human and rodent hypertension. Moreover, this project will evaluate the potential for sub-diaphragmatic vagal stimulation as bio-electronic medicine approach for alleviating the symptoms of gut dysbiosis in hypertension. This would represent a significant advancement in our understanding of host-microbiota interactions in health and disease, and has a potential for an immediate and significant impact in treatment of hypertension.

PI_NAMEs: ZUBCEVIC, JASENKA  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Address;Affect;Afferent Neurons;aggressive therapy;American;Anatomy;Animals;Autonomic nervous system;bioelectronics;Blood Pressure;blood pressure elevation;blood pressure reduction;Brain;Calcium;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Chronic;Colon;comorbidity;Data;Dementia;Diabetes Mellitus;Disease;dysbiosis;Effectiveness;Electric Stimulation;Electrophysiology (science);Event;experimental study;fecal transplantation;Feedback;Fiber;Functional disorder;Future;gut dysbiosis;gut microbiota;gut-brain axis;Health;host microbiota;HTR3A gene;Human;human microbiota;Hypertension;hypertension treatment;hypertensive;Impairment;improved;in vivo imaging;innovation;Investigation;Kidney Diseases;Length;Life Style Modification;Link;Maps;Mediating;Medicine;microbiota;Modeling;Molecular;Monitor;Nerve;nerve supply;Nervous System Disorder;neural;neural stimulation;neuromechanism;Neurons;Nodose Ganglion;Norepinephrine;normotensive;novel;Nucleus solitarius;Obstructive Sleep Apnea;optogenetics;Outcome;Patients;Pattern;Pharmacotherapy;Plasma;prevent;Prevention;Production;Public Health;Rat Transgene;Rattus;receptor;Receptor Signaling;reduce symptoms;Reflex action;Refractory;Regulation;Research;Resistance;Resistant Hypertension;response;Risk Factors;Rodent;Role;Serotonin;Signal Transduction;Site;social;Stroke;Telemetry;Therapeutic;Time;Tracer;Transgenic Organisms;translational impact;translational model;Transplantation;Vasomotor;Viral

PROJECT_TITLE: Neural mechanisms of host-microbiota interaction in hypertension: a potential for bio-electronic medicine

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Stroke

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will model the network bases of aphasia in a uniquely informative cohort of neurosurgical patients, providing a distinct perspective on the pathophysiology of acquired language disorders that affect close to 1 million Americans today. A better understanding of the causal role of networks and connections in supporting language function carries the potential for improved patient care via better prediction of language outcomes and more effectively targeted neural interventions. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to reducing the burdens of illness and disability.

PI_NAMEs: LEVY, DEBORAH  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acquired Language Disorders;Acute;Affect;American;Aphasia;Area;base;Behavior;Brain;Brain region;burden of illness;cohort;Comprehension;Data;Data Set;disability;Electrocorticogram;Excision;Exhibits;experience;Functional disorder;Goals;healing;improved;Individual;innovation;insight;Intervention;Language;language outcome;language processing;large datasets;Lead;Lesion;Literature;Maps;Measures;Mentors;Mission;Modeling;Monitor;multimodal modeling;multimodality;network models;Network-based;neural;neural model;Neurodegenerative Disorders;neuroimaging;neurophysiology;neurosurgery;Operative Surgical Procedures;Outcome;Pathway Analysis;Patient Care;Patients;Pattern;Play;Population;Primary Lesion;Process;Public Health;Research;Resected;Role;Site;Stereotyping;Stroke;Symptoms;Syndrome;Time;Tissues;tool;United States National Institutes of Health;white matter;white matter damage;Work

PROJECT_TITLE: Modeling the neural bases of aphasia in neurosurgical patients: A multivariate, connectivity-based approach


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: MADISON

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Frontotemporal dementia (FTD) is an Alzheimer’s disease-related dementia that has been linked to mutations in the gene encoding for the tau protein (MAPT). This proposal aims to create a resource to study FTD by taking advantage of a family of rhesus monkeys carrying an exact replicate of an FTD-related mutation (MAPT R406W). This project has the potential to help patients as the resource will facilitate the study of mechanisms of FTD neurodegeneration, as well as biomarker and therapy development.

PI_NAMEs: CHEN, RUI ;EMBORG, MARINA  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: 17q21;Age;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Animal Model;Animals;Atrophic;autosome;Axon;Behavior;behavior test;Behavioral;Belgium;biomarker development;biomarker identification;Brain;Breeding;Brothers;Caring;Cell Line;Cells;Central Nervous System;Chromosomes;Cognitive;Collaborations;college;Communities;Data;Dementia;Denmark;Discipline;Disease;disease model;Family;Family member;Female;Fibroblasts;Foundations;Frontotemporal Dementia;Generations;Genes;Genetic;Genetic Models;genetic pedigree;genome sequencing;Genotype;Gliosis;Goals;Human;human model;Image;In Vitro;in vivo;induced pluripotent stem cell;Iran;Japan;Language Disorders;Link;Macaca mulatta;Magnetic Resonance Imaging;MAPT gene;Medicine;member;Memory Loss;Microtubule-Associated Proteins;Microtubules;Midwestern United States;Missense Mutation;Modeling;Moods;Motor;Mutate;Mutation;mutation carrier;Nerve Degeneration;Netherlands;neural;Neuroanatomy;neurobehavioral;Neurodegenerative Disorders;neuron loss;Neurons;nonhuman primate;offspring;Outcome Measure;Parkinsonian Disorders;Pathologic;Patients;Peripheral Nervous System;Personality;Phase;Phenotype;Point Mutation;Primates;programs;Protein Family;Proteins;Records;Reporting;Research;Research Personnel;Resources;Rhesus;Role;sex;stem cells;Sweden;Symptoms;System;tau aggregation;tau Proteins;tau-1;Tauopathies;therapeutic target;therapy development;translational neuroscience;United States;Visualization;whole genome;Wisconsin

PROJECT_TITLE: Modeling Frontotemporal Dementia in Rhesus Macaques

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-E(56)]


ORG_CITY: ATLANTA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Public Health Relevance Statement: Skeletal muscles are now being considered as an endocrine organ. Although several hundreds of muscle secretome have been reported, their biological function is relatively unknown due to the lack of reliable tools for identification. The proposed work will provide an innovative approach to develop a biomimetic model system for more accurate and cost-effective identification of muscle-derived humoral factors with therapeutic potentials.

PI_NAMEs: JANG, YOUNG CHARLES (contact);PARK, SUNG JIN

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;Accounting;Acute;Animal Model;Arteries;Binding;Biochemical;Biological Markers;Biological Models;Biological Process;Biology;Biomimetics;Biopsy;Blood;Cardiac;Cardiovascular Diseases;Categories;Cell Physiology;cell type;Cells;Chemistry;Chronic;Circulation;Communication;cost effective;Cues;cytokine;Dementia;Detection;detection platform;Disease;Dose;Endocrine;Endocrine Glands;endurance exercise;Engineering;Exercise;exercise regimen;Exercise Therapy;exercise training;Factor Analysis;Genetic;Goals;Hindlimb;Human body;Hypoxia;In Vitro;in vivo;innovation;Ischemia;Ischemic Preconditioning;Label;Left;Life Style;Ligation;Limb structure;Malignant Neoplasms;Mechanics;Medicine;Methionine-tRNA Ligase;Microfluidics;microphysiology system;minimally invasive;mouse model;Muscle;Muscle Contraction;Muscle Proteins;muscle regeneration;Myocardial Ischemia;Myocardium;myogenesis;Myopathy;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Operative Surgical Procedures;Optics;optogenetics;Organ;Outcome;Patients;Physical activity;Physiological;Point Mutation;Post-Translational Protein Processing;protective effect;Protein Biosynthesis;Proteins;Proteome;Proteomics;public health relevance;receptor;Reporter;Reporting;Research;Rhodopsin;Role;Sampling;sarcopenia;Second Messenger Systems;sedentary;skeletal;Skeletal Muscle;spatiotemporal;System;Testing;Therapeutic;Time;Tissues;tool;Tourniquets;Transgenes;Translating;translational potential;treadmill;Validation;Vascularization;Work

PROJECT_TITLE: 3D micro-physiological systems for identification of therapeutic myokines

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Our project is focused on characterizing genetic features of colorectal cancer among major Latino subgroups in the United States (i.e. Mexican/Central American and Caribbean), who differ in ancestral backgrounds and colorectal cancer mortality rates. Our aims are to identify new cancer driver mutations present in Latinos with high indigenous American or African ancestry and to test their implications for treatment response and prognosis. This area of research has received limited attention despite the compelling advantages of studying admixed populations for optimizing treatment strategies targeted to individuals of specific heritage.

PI_NAMEs: FIGUEIREDO, JANE C.;SCHMIT, STEPHANIE L. (contact)

PROGRAM_OFFICER_NAME: MECHANIC, LEAH E

PROJECT_TERMS: Accounting;Address;Admixture;African;African American;African American population;African ancestry;Age;Area;Attention;biobank;Biological;Biological Assay;Biological Factors;Biological Products;Birth Place;cancer care;Cancer Center;cancer health disparity;Caribbean region;caucasian American;Central American;Cessation of life;Characteristics;chemotherapy;Clinical;clinical application;clinical predictors;clinically actionable;cohort;Colorectal Cancer;Communities;Cuban;Data;Data Set;Death Rate;demographics;Disparity;Disparity population;driver mutation;Epidemiology;epidemiology study;ethnic minority;Ethnic Origin;Ethnic Population;European;evidence base;exome;exome sequencing;experience;Frequencies;Fresh Tissue;Genetic;Goals;Haplotypes;Health Services Accessibility;Hispanic;Hispanic Populations;Indigenous American;Individual;individualized medicine;Inequality;innovation;KRAS2 gene;Latino;Latino Population;leukemia relapse;Malignant Neoplasms;men;metastatic colorectal;Mexican;Microsatellite Instability;Minority;mortality;Mutation;National origin;Not Hispanic or Latino;novel;Outcome;outcome disparities;Participant;Pathway interactions;patient derived xenograft model;Patient Self-Report;Pattern;Population;Population Heterogeneity;Positioning Attribute;predictive modeling;Prevalence;Prognosis;prognostic;Prognostic Factor;prospective;Puerto Rican;Puerto Rico;Race;racial minority;racial population;recruit;relapse risk;Research;Resources;response;Role;Sample Size;screening;Shapes;sociodemographic factors;sociodemographics;Socioeconomic Status;Somatic Mutation;South American;Subgroup;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic Agents;Time;Tissues;Treatment Efficacy;treatment guidelines;treatment optimization;treatment response;treatment strategy;tumor;tumor microenvironment;tv watching;Underrepresented Minority;United States;Variant;Woman

PROJECT_TITLE: Biological determinants of colorectal cancer outcomes in Latinos of diverseýancestral origins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Rare Diseases

ORG_DEPT: NEUROLOGY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Since there is no accepted animal model of myositis (inflammation of muscle), this study aims to characterize and utilize the first mouse models. Importantly, we will use these models to help understand whether Inclusion Body Myositis (IBM), the most common late adult-onset muscle disease, is primarily a degenerative disease or an autoimmune disease. These "personalized" and "humanized" mouse models will be used to validate novel therapeutic targets for this devastating myodegenerative disease.

PI_NAMEs: LLOYD, THOMAS E.;WONG, PHILIP C (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Adult;Age;Aging;Animal Model;Atrophic;Attenuated;Autoimmune Diseases;autoreactivity;Binding;Biopsy;CD8-Positive T-Lymphocytes;Cell Count;cell type;Cells;Characteristics;Classification;Clinical;clinically relevant;cytokine;Cytoplasm;Data;Degenerative Disorder;Disease;disease model;efficacy evaluation;Exons;extend lifespan;Goals;Haplotypes;Human;human disease;humanized mouse;illness length;Immune response;Immune system;Immunocompromised Host;Immunodeficient Mouse;Immunohistochemistry;Immunosuppression;Immunotherapy;Implant;improved;in vivo Model;Inclusion Body Myositis;Inflammation;Inflammatory;Inflammatory Response;insight;Invaded;Messenger RNA;Modeling;mouse model;Mus;Muscle;muscle degeneration;muscle regeneration;Muscle satellite cell;Muscular Atrophy;Myopathy;Myositis;Natural regeneration;Neurodegenerative Disorders;Neurons;new therapeutic target;novel;Nuclear;Pathogenesis;Pathologic;Pathology;Patients;Proliferating;protein aggregation;protein TDP-43;Repression;response;RNA;RNA Splicing;RNA-Binding Proteins;Role;Secondary to;Skeletal Muscle;Sporadic Inclusion Body Myopathy;T-Cell Proliferation;T-Lymphocyte;Testing;Therapeutic;therapeutic development;therapeutic target;Time;Tissues;transcriptome;transcriptome sequencing;Transplantation;Treatment Efficacy;Up-Regulation;Vacuole;Validation;validation studies;Viral;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Pathogenesis and treatment of sporadic Inclusion Body Myositis in mouse models.

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SAINT LOUIS

ORG_DEPT: GENETICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Genome science refers to high-throughput, technology intensive, and computational approaches to understanding how variation in the human genome translates into phenotypic differences between individuals. The proposed program will train PhD and MD/PhD students to drive innovation in genome science and to apply their discoveries to improving patient outcomes.

PI_NAMEs: BRENT, MICHAEL R (contact);COHEN, BARAK A

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TITLE: Institutional Training Grant in Genomic Science


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Relevance As a result of population aging, many low- and middle-income countries such as Lebanon face a rapidly growing burden of dementia. This proposal represents a collaboration between the American University of Beirut and the University of Michigan to develop a program of research capacity building and a population- based study to identify important new risk factors for dementia in Lebanon as well as the caregiver needs and arrangements for older adults. Findings from this program are expected to have substantial relevance for a better understanding of dementia risks and associated care needs in Lebanon and other low-resource settings around the world.

PI_NAMEs: MENDES DE LEON, CARLOS F. (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Adult;Affect;Age;age related;age related chronic disease;aged;aging population;aging related;Alzheimer's disease care;Alzheimer's disease related dementia;Alzheimer's disease risk;American;analytical method;Caregivers;caregiving;Caring;Chronic stress;Climacteric;Cognitive;cognitive interview;cohort;Cohort Studies;Collaborations;Complex;Conflict (Psychology);Country;Data;Dementia;dementia burden;dementia risk;Demographic Transitions;design;Development;Education;epidemiology study;Ethnic Origin;experience;Exposure to;Face;Family;Family Relationship;family support;follow-up;Foundations;Future;Goals;Growth;Health;Healthcare;Impaired cognition;Incidence;Income;informal care;innovation;insight;instrument;Interdisciplinary Study;interest;Intervention Studies;Knowledge;late life;Lebanon;Life;Life Cycle Stages;Long-Term Care;Longitudinal Studies;Longitudinal Surveys;low and middle-income countries;Methods;Michigan;Middle East;Migrant Workers;Modeling;Northern Africa;novel;Observational Study;older adult;Older Population;Outcome;Pattern;Politics;Population;population based;Population Research;Population Study;population survey;Prevalence;Prevention strategy;programs;Quality of Care;recruit;Research;Research Design;Research Methodology;Research Personnel;Resource-limited setting;Resources;Respondent;Risk Factors;Role;Sampling;Series;sex;social;Social Conditions;Social outcome;Socioeconomic Status;socioeconomics;Solid;Structure;Surveys;Techniques;Testing;traditional care;Training Activity;Universities;virtual;Work

PROJECT_TITLE: Dementia and Related Health and Social Challenges in Lebanon: A Population Study


NIH_SPENDING_CATS: Genetics

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE T cells in the immune system develop through a multi-step process in which they first proliferate strongly to make many cells, then commit themselves entirely to develop as T cells, and only then start to express T-cell properties. This project grows from surprising evidence that certain genes that are best known for their abnormal role in leukemia may normally have another, benign role in the early developmental stages of T cells. The project tests whether this is true and what mechanisms the normal cells must therefore be using to exploit these genes while preventing them from causing leukemia.

PI_NAMEs: ROTHENBERG, ELLEN V. (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Acute;Acute Lymphocytic Leukemia;Affect;B-Lymphocytes;Benign;BHLH Protein;Binding;Binding Sites;Biochemical;Cell Cycle;Cell Differentiation process;Cell Lineage;Cells;Chromatin;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;Development;differentiation in vitro;dimer;Dimerization;Dose;Down-Regulation;E protein;Enzymes;Event;GATA3 gene;Gene Expression;gene network;gene product;Gene Rearrangement;gene regulatory network;Genes;genetic signature;Genome;genome-wide;Genomics;Helix-Turn-Helix Motifs;Heterodimerization;Human;Immune;Immune system;In Vitro;in vivo;Inhibitor of Differentiation Proteins;Kinetics;leukemia;Lymphoid Cell;Maps;Molecular;Monitor;Mutate;network architecture;Normal Cell;Oncogenes;Phase;Phenotype;Population Dynamics;preservation;prevent;Probability;Process;programs;Proliferating;Property;protein complex;Proto-Oncogenes;Rag1 Mouse;Regulation;Regulator Genes;Regulatory Element;response;Role;Site;stem cells;T cell differentiation;T-Cell Development;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;TCF3 gene;Testing;Thymus Gland;transcription factor;Work

PROJECT_TITLE: Lmo2-Lyl1 and the bHLH factor network in pro-T cells

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DAVIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Knowledge of macromolecular structure plays a crucial role in biology and medicine, allowing for detailed studies and understanding of biological processes and disease mechanisms. Yet, relatively few structures are obtained experimentally - the rest must be modeled. The Critical Assessment of Structure Prediction program (CASP), provides the primary means of evaluating performance of the methods dedicated to this task.

PI_NAMEs: FIDELIS, KRZYSZTOF A (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 2019-nCoV;Address;Area;Automobile Driving;Benchmarking;Biological;Biological Process;biological research;Biology;Categories;Chemicals;Collaborations;Collection;Communication;Communities;Community Developments;Complex;Computer Models;Computer software;Consumption;convolutional neural network;cost;crosslink;Cryoelectron Microscopy;Crystallography;Data;data acquisition;data handling;data infrastructure;Data Set;Dedications;deep learning;design;Development;Disease;Double-Blind Method;Drug Design;Epitopes;Evaluation;experimental study;Fostering;Future;Goals;Homology Modeling;improved;Information Dissemination;Infrastructure;International;Journals;Knowledge;Laboratories;Life;Machine Learning;Medicine;meetings;member;method development;Methods;model building;Modeling;Molecular Biology;Molecular Structure;online resource;operation;Paper;Participant;Performance;Play;Procedures;Process;programs;protein structure;Proteins;Provider;Publications;Reporting;Research;Resources;Rest;Role;Sampling;Seasons;Secure;Sequence Alignment;Series;structural biology;Structure;success;symposium;Techniques;Tertiary Protein Structure;Time;vaccine development;Validation;Visualization;webinar;Work

PROJECT_TITLE: Center for Critical Assessment of Structure Prediction (CASP)

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it is expected to improve the ability of eye care providers to better assess the three-dimensional changes in the posterior eye that result from changes in progressive and pathologic myopia or high intracranial pressure, all potentially visually disabling diseases. Leveraging innovative imaging technologies developed by our laboratories and specifically designed analysis of posterior eye shape, we expect to provide quantitative information about these posterior eye deformations to support clinical care and research into the anatomical changes involved in these diseases.

PI_NAMEs: KUO, ANTHONY NANLIN (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 3-Dimensional;Accounting;Adult;Affect;Anatomy;Biomedical Engineering;Biometry;care providers;Caring;Child;Childhood;Clinical;clinical care;Clinical Research;clinical research site;Compensation;Computer software;cost;Data;Deformity;Degenerative Myopia;Descriptor;design;Development;diagnostic criteria;disabling disease;Disease;Disparity;Early identification;Edema;epidemiology study;Evolution;Excision;Eye;Image;imaging biomarker;imaging modality;Imaging technology;improved;innovation;Intracranial Hypertension;Intracranial Pressure;Laboratories;Light;Magnetic Resonance Imaging;Maps;Measurement;Morphologic artifacts;Morphology;morphometry;Motion;multidisciplinary;Myopia;neuroimaging;next generation;novel;Ophthalmologist;Optical Coherence Tomography;Optics;Outcome;Pathologic;Pathology;Patient Care;Patient imaging;Patients;Performance;Peripheral;Progressive Myopia;Public Health;Research;Research Proposals;Resolution;Retina;retinal nerve fiber layer;serial imaging;Shapes;Site;skills;Source;Swelling;System;Techniques;Technology;Testing;Therapeutic;Treatment Efficacy;Visual disability

PROJECT_TITLE: Whole Eye Optical Coherence Tomography to Improve Eye Care


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Violence is an urgent public health problem which reflects and reinforces social inequities, and high-quality early childhood education programs hold promise in addressing multiple sources of risk and resilience for inter- personal violence and self-directed harm. This project uses nationally-representative longitudinal survey data spanning several decades to estimate the effects of Head Start, a large-scale, comprehensive early childhood education intervention, 1) inter-generationally on suicidal ideation and inter-personal violence perpetration, and 2) intra-generationally on handgun carrying and inter-personal violence perpetration, along with interactive effects of demographic, social, economic, and environmental factors. This project will inform early childhood education and violence prevention policies and support the F31 candidate in developing methodological and content expertise needed to become an independent investigator.

PI_NAMEs: SCHLEIMER, JULIA  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Address;Adolescence;Adult;Affect;Age;aged;assault;Cause of Death;Cessation of life;Child;Child Support;cohesion;cohort;Communities;Data;Demographic Factors;design;Development;Disadvantaged;early childhood;early life adversity;Economic Factors;economic indicator;economic outcome;Economics;Education;Educational Intervention;Employment;Environmental Risk Factor;Ethnic Origin;Etiology;Exhibits;experience;Exposure to;Family;Feeling suicidal;firearm access;Generations;handgun;Head Start Program;Health;Health Services;high risk;Homicide;improved;Individual;Inequity;intergenerational;Interpersonal Violence;Intervention;Investments;Life;Life Cycle Stages;Link;Long-Term Effects;Longitudinal Studies;Longitudinal Surveys;Maximum Likelihood Estimate;Mental Health;Methodology;Methods;Mind;National Longitudinal Survey of Youth;neighborhood disadvantage;Nursery Schools;offspring;Participant;Persons;physical conditioning;Policies;Policy Analysis;Population;population health;Poverty;prevent;Primary Prevention;programs;protective factors;Public Health;Public Policy;Quasi-experiment;Race;Racial Equity;Reporting;Research;Research Personnel;resilience;Risk;Risk Factors;risk sharing;scale up;Scholarship;Self Direction;Self-Injurious Behavior;sex;social;Social Conditions;social determinants;Social Environment;social epidemiology;social factors;Social outcome;Social Policies;Social Work;Source;structural determinants;Structural Racism;suicidal risk;Suicide;Techniques;theories;Time;tool;Training;transmission process;United States;Variant;Victimization;Violence;violence perpetration;violence prevention;violent crime;young adult

PROJECT_TITLE: Early Childhood Education and Violence Prevention Across the Life Course and Generations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: IOWA CITY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: RELEVANCE TO PUBLIC HEALTH This study seeks to understand the long-term consequences to lung function in patients who recover from the novel coronavirus disease 2019 (COVID-19). The proposed deep learning algorithms will utilize chest X-ray and computed tomography images to identify post-COVID-19 progression subtypes and establish their associations with distinct clinical, imaging and mechanistic biomarkers. The knowledge gained from this study will improve the management and treatment of post-COVID-19 patients.

PI_NAMEs: LIN, CHING-LONG  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Air;Alveolus;Biological Markers;Characteristics;Chronic Obstructive Pulmonary Disease;Classification;Clinic;Clinical;Clinical assessments;clinical biomarkers;Clinical Data;cohort;cost;COVID-19;COVID-19 patient;COVID-19 survivors;Data;Data Analyses;Dedications;deep learning;deep learning algorithm;deep learning model;Development;Dimensions;Disease;Exhibits;experience;Exposure to;fibrotic lung;follow-up;Goals;Health;Healthcare;human subject;Image;imaging biomarker;improved;in silico;in vivo;Iowa;Knowledge;Learning;learning algorithm;learning strategy;Liquid substance;Long-Term Effects;long-term sequelae;Lung;lung imaging;Modeling;novel coronavirus;Outcome;particle;Patient Care;Patients;Phenotype;phenotypic biomarker;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;pre-trained model;prototype;Public Health;Pulmonary Emphysema;pulmonary function;Radiation Dose Unit;Recommendation;Research;Resolution;SARS-CoV-2 infection;self supervised learning;Site;small airways disease;Structure of parenchyma of lung;Study Subject;Techniques;Testing;Thoracic Radiography;Time;Training;transfer learning;Universities;Validation;Virus Diseases;Visit;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: Deep Learning and Subtyping of Post-COVID-19 Lung Progression Phenotypes

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Lung;Nutrition;Obesity;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Asthma has increasing worldwide incidence and female sex and obesity are risk factors for severe forms of disease that can resist standard therapies. We have found that T cell glutamine uptake and metabolism play key roles to regulate gene expression and inflammation that could contribute to severe asthma. This study will test two candidate targets to suppress glutamine metabolism in animal models and patient samples and determine if this pathway may provide new therapeutic targets to overcome severe therapy resistant asthma.

PI_NAMEs: NEWCOMB, DAWN C;RATHMELL, JEFFREY C. (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Affect;Airway Disease;airway hyperresponsiveness;airway inflammation;airway remodeling;Allergens;allergic airway inflammation;alpha ketoglutarate;Amino Acids;Animal Model;Asthma;asthma exacerbation;asthmatic patient;Automobile Driving;Bronchial Spasm;CD4 Positive T Lymphocytes;Cell Physiology;Cell Separation;Cells;Cellular Metabolic Process;Characteristics;Chromatin;chronic inflammatory disease;chronic respiratory disease;Clinic;Clinical;CRISPR screen;cytokine;Cytometry;Data;Dependence;Development;diet-induced obesity;Disease;effector T cell;Electron Transport;Enzymes;eosinophil;Epigenetic Process;Equilibrium;ESR1 gene;Estrogen Receptors;Female;Frequencies;Gene Expression;Gene Targeting;Generations;Genes;Genetic;Glucose;glucose metabolism;Glutamates;Glutaminase;Glutamine;Glycolysis;Guanine Nucleotide Exchange Factors;health disparity;Hexosamines;high dimensionality;High Fat Diet;High Risk Woman;IL17 gene;IL4 gene;Immune;immune function;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;inhibitor;Liquid substance;Lung;Lung Lavage Fluid;Mediating;men;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Marker;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;mitochondrial metabolism;Modeling;mouse model;Mucous body substance;Mus;neutrophil;new therapeutic target;novel therapeutics;Obesity;obesity risk;obesity-associated asthma;Oxidation-Reduction;Pathway interactions;Patients;peripheral blood;Play;Population;Process;Production;programs;protective pathway;Pulmonary Inflammation;Pyroglyphidae;Regulatory T-Lymphocyte;Resistance;Respiration;Risk;Risk Factors;Role;Sampling;Severities;sex;T cell differentiation;T cell regulation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Th2 Cells;Therapeutic;therapy resistant;Translating;uptake;Weight;Woman;women versus men

PROJECT_TITLE: Targeting T cell glutamine metabolism in severe asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Since their discovery almost 50 years ago how opioid receptors facilitate the development of dependence and withdrawal at a circuit level is still not known. To address this question, we will chart the global cell-type identity, shifting connectivity, and ensemble activity of opioidergic networks by examining brains throughout various stages of addiction. By leveraging cutting-edge neuroscience technologies, we will map and profile neuronal ensembles and cell-types that mediate opioid action in the rodent brain.

PI_NAMEs: BLENDY, JULIE A (contact);CORDER, GREGORY

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Abstinence;Acceleration;Acute;addiction;Address;Adopted;Anatomy;Architecture;Atlases;Axon;Behavior;behavior measurement;Biological;Brain;Brain region;cell type;Cells;Characteristics;Chronic;Classification;combat;control theory;Coupled;Data Set;Databases;Dependence;Development;Disease;Drug usage;endogenous opioids;Epidemic;Evolution;experimental study;Future;Gene Expression;gene network;Generations;Genes;Genetic;Genetic Transcription;Genomics;Graph;Head;high throughput screening;Image;improved;In Situ Hybridization;Incidence;innovation;Label;Lifestyle-related condition;Machine Learning;Maps;mathematical model;Measurement;Mediating;Methods;Microscope;Modeling;mu opioid receptors;neural;neural circuit;neural network;neuroadaptation;Neurons;Neurophysiology - biologic function;Neurosciences;next generation;novel;Opiate Addiction;Opioid;opioid epidemic;opioid exposure;opioid mortality;Opioid Peptide;Opioid Receptor;opioid use disorder;opioid withdrawal;Output;Pain;Pathologic;Pharmaceutical Preparations;Population;Relapse;Research;Research Personnel;Resolution;Rodent;Role;Sampling;searchable database;single nucleus RNA-sequencing;Site;synthetic opioid;System;Technology;theories;Therapeutic;Time;Tissues;tool;transcriptomics;virus genetics;Visualization;Withdrawal

PROJECT_TITLE: Mapping opioid-dependence state transitions across structural, functional, and transcriptomic topologies


ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Evolutionary adaptation is the foundation concept in biology and is at the center of many problems facing humanities such as cancer, infectious disease including the jumps of viruses from other species to humans, and drug resistance. Using a series of related projects the Petrov lab will pursue empirical, computational, and theoretical research aimed at building a rich predictive and quantitative theory of adaptation.

PI_NAMEs: PETROV, DMITRI  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Biology;Communicable Diseases;de novo mutation;Drosophila genus;Drug resistance;Engineering;Evolution;experimental study;Foundations;genomic data;Genomics;Growth;Human;Humanities;Malignant neoplasm of lung;Malignant Neoplasms;Modality;mouse model;Organism;Pattern;Research;Seasons;Series;System;theories;Time;tumor initiation;Variant;Virus;Yeasts

PROJECT_TITLE: Genomics of rapid adaptation in the lab and in the wild

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative We will develop statistically principled computational methods, algorithms, and tools to efﬁciently, comprehen- sively, and quantitatively proﬁle chromatin organization, to further elucidate the dynamics of transcriptional regulation, and to link the two through predictive models that provide mechanistic insight into how a cell's chromatin state inﬂuences—and is inﬂuenced by—its transcriptional state. Successfully achieving this would have enormous scientiﬁc and practical impact by enhancing our understanding of fundamental processes like cell growth and division, signal and stress response, and differentiation, as well as clinically relevant consequences of their dysregulation, whether in cancer, diabetes, or developmental disorders. We seek to develop computational methods that provide mechanistic answers to foundational questions about how cells function and are therefore broadly applicable across organisms, including humans.

PI_NAMEs: HARTEMINK, ALEXANDER J (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Algorithms;Biological;biological adaptation to stress;Biological Assay;Cell Cycle;Cell division;cell growth;Cell Physiology;Cell Proliferation;Cells;Chromatin;chromatin remodeling;clinically relevant;Complex;Computing Methodologies;Data;developmental disease;Diabetes Mellitus;dynamic system;Environment;environmental stressor;Event;fundamental research;Genes;genetic strain;Genetic Transcription;Genome;genome-wide;Genomics;Goals;Hormones;Human;insight;Knowledge;Link;Malignant Neoplasms;Methods;Modeling;Monitor;mutant;Organism;predictive modeling;Process;Production;programs;protein complex;Regulation;Research;response;Saccharomycetales;Series;Signal Transduction;Statistical Methods;Technology;Testing;Time;tool;Transcript;Transcriptional Regulation;Yeasts

PROJECT_TITLE: Methods to Elucidate the Dynamics of Transcriptional Regulation and Chromatin


ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: PROJECT NARRATIVE Founded in 2010, the Human Immune Profiling Consortium (HIPC) has successfully brought together independent research centers to identify immune signatures associated with the outcomes of vaccinations and infections in humans. We propose to develop a HIPC Coordinating Center (HCC) that supports the HIPC network by providing a centralized Portal and Knowledgebase to facilitate data analysis and visualization, and to promote collaborations across the network by organizing subcommittees and cross-HIPC analysis projects.

PI_NAMEs: KLEINSTEIN, STEVEN H.;PETERS, BJOERN  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Adopted;Area;Awareness;base;Biological Assay;centralized portal;Clinical;clinical phenotype;Clinical Research;Collaborations;Communication;Communities;Conflict of Interest;Coupled;Data;Data Analyses;Data Coordinating Center;data portal;data sharing;data standards;data visualization;Decision Making;Dedications;Development;Ensure;Expenditure;experience;FAIR principles;Familiarity;Fostering;Funding;Funding Opportunities;Grant;Human;Human Activities;Human Characteristics;Immune;Immune response;Immunology;improved;Infection;Infrastructure;Institution;International;Investments;Knowledge;knowledgebase;Lead;Learning;Life;Measures;meetings;Methods;Modeling;National Institute of Allergy and Infectious Disease;operation;organizational structure;outreach program;Procedures;Process;programs;promoter;Publications;Reporting;Request for Applications;Research;Running;social media;Standardization;success;System;Teleconferences;Time;timeline;tool;Twitter;Update;Vaccination;vaccination outcome;Visualization;web site;Work

PROJECT_TITLE: HIPC Data Coordinating Center


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Physical Rehabilitation;Rehabilitation

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Speech deficits are among the most prevalent and impairing of clinical features for individuals with Autism Spectrum Disorder (ASD), yet the specific barriers to speech production are poorly understood, and consequently, the existing treatments do not target the source of the problem. The objective of this study is to characterize the specific processes in the speech motor system in participants with ASD in order to understand the factors that lead to impaired speech. The long-term goal is to identify new directions for novel approaches to treatment that target the specific barriers to speech for individuals with ASD.

PI_NAMEs: DEMOPOULOS, CARLY  (contact);LI, YAN

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Adolescent;Affect;Age;Auditory area;auditory feedback;auditory processing;autism spectrum disorder;autistic children;Behavioral;Brain;Brain imaging;Chemicals;Child;Clinical;clinical phenotype;Communication;Compensation;Control Groups;Cross-Sectional Studies;Data;Development;Feedback;Functional disorder;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Glutamates;Goals;Hearing problem;Heterogeneity;Impairment;indexing;Individual;individuals with autism spectrum disorder;Language;Learning;Link;Literature;Magnetic Resonance Spectroscopy;Magnetoencephalography;Measures;Methods;minimally verbal;Modeling;Motor;motor control;Motor Cortex;neural;neuromechanism;Neuropsychology;Neurotransmitters;novel;novel strategies;Participant;Pathologic Processes;Pathology;Pattern;Performance;Process;Production;Prognosis;Psychophysics;Quality of life;Reproducibility;response;Rest;sensory feedback;Socialization;Source;Speech;speech accuracy;Speech Therapy;Standardization;Symptoms;System;Testing;theories;Time;Translating;Work

PROJECT_TITLE: Neural mechanisms of speech motor control in Autism Spectrum Disorders

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Infertility, which affects 10-15% of couples, can be caused by impaired egg and/or sperm production (gametogenesis). There remain key limits to our understanding of the gametogenesis processes, especially how sophisticated gene expression programs operate during these processes, impeding fundamental science and the diagnosis and treatment of infertility. To address these limits of knowledge we will build upon our discoveries of previously uncharacterized RNA-binding proteins that are crucial for gametogenesis, to now elucidate their molecular functions and mechanisms of action in the gene expression programs during gametogenesis.

PI_NAMEs: FUKUNAGA, RYUYA  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3' Untranslated Regions;Address;Affect;Binding;Cell Maintenance;Complex;Couples;Data;Diagnosis;DNA Sequence;Drosophila genus;egg;F Factor;Family;female fertility;Fertility;fly;Gametogenesis;Gene Expression;Gene Expression Regulation;Genes;germline stem cells;Human;Impairment;improved;In Vitro;in vivo;Infertility;infertility treatment;Introns;Knowledge;Length;male fertility;Messenger RNA;MicroRNAs;Molecular;Molecular Mechanisms of Action;mutant;Mutation;novel;Oocytes;Oogenesis;Orthologous Gene;Ovary;Play;Poly(A) Tail;polyadenylated messenger RNA;Post-Transcriptional Regulation;Process;Production;programs;Proteins;Regulation;RNA;RNA Binding;RNA Sequences;RNA Splicing;RNA-Binding Proteins;Role;Science;spatiotemporal;sperm cell;Spermatocytes;Spermatogenesis;Structure;Testing;Translations;trying to conceive;Y Chromosome

PROJECT_TITLE: Investigating the molecular functions and mechanisms of RNA-binding proteins crucial for gametogenesis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: The UNM HSC CTSC 3.0 will catalyze scientific discovery into improved health. We will accomplish this by catalyzing high quality clinical and translational research that addresses our geographic needs statewide, regionally, and within our networks.

PI_NAMEs: CAMPEN, MATTHEW J;PANDHI, NANCY  (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Acceleration;Achievement;Address;Affect;Award;barrier to care;Biological Sciences;Biomedical Research;Businesses;career development;Center for Translational Science Activities;Clinical;clinical center;Clinical effectiveness;Clinical Research;Clinical Sciences;Collaborations;Communities;County;Data;Development;Discipline;Ecosystem;Ensure;Environment;ethnic diversity;Ethnic Origin;Face;Fostering;Funding;Funding Opportunities;Geographic state;Geography;Goals;Health;health disparity;health disparity populations;health organization;Health Sciences;Healthcare;Hispanic;improved;Industry;Informatics;innovation;Institution;Knowledge;Laboratories;Life;life span;Medical;Methods;Minority;Mission;National Center for Advancing Translational Sciences;National Institute of General Medical Sciences;Native Americans;Network Infrastructure;New Mexico;operation;opioid epidemic;Overdose;Patients;Phase;Population;population health;Positioning Attribute;prescription opioid;Process;programs;Provider;Race;Research;Research Personnel;Resources;Rural;rural area;Schools;Science;Services;skills;Social Work;Special Population;Technology;tool;Training;Translating;Translational Research;Translations;Universities;Vision;Workforce Development

PROJECT_TITLE: UNM HSC Clinical and Translational Science Center


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Women's Health Research

ORG_CITY: SAN MARCOS

ORG_NAME: CALIFORNIA STATE UNIVERSITY SAN MARCOS

PHR: Project Narrative Crosstalk between breast cancer cells and adipocytes results in tumor invasiveness, sustained cancer growth, and increased acquisition of aggressive tumor phenotypes. This proposal aims to create multicellular tumor spheroids to study changes in tumor invasiveness when cancer cells are co-aggregated with adipocytes. Multicellular tumor spheroids will be created using a custom surface vibration bioreactor, which will test the potential to generate tumor spheroids with improved cell-cell adhesion and scalability.

PI_NAMEs: LUNA LOPEZ, CARLOS  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: 3-Dimensional;adipocyte differentiation;Adipocytes;Adipose tissue;Affect;Animal Model;anti-cancer research;Antineoplastic Agents;Attention;Biological;Biological Assay;Bioreactors;Breast;Breast Cancer Cell;Breast Cancer cell line;Brown Fat;Cancer Biology;cancer cell;Cancer cell line;Cancer Model;cancer type;Cell Aggregation;cell behavior;Cell Differentiation process;Cell Proliferation;cell type;Cell-Cell Adhesion;Cells;Cellular Spheroids;Chemicals;Chemoresistance;Coculture Techniques;Custom;density;Devices;drug discovery;Environment;Epidemic;ERBB2 gene;Exhibits;Gene Expression;Geometry;Goals;Grant;Growth;Heterogeneity;Human;implantation;improved;In Vitro;in vivo;innovation;Invaded;Kidney;Liquid substance;Literature;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Methods;migration;Modeling;Modernization;Mus;Ovarian;Phenotype;Physiological;Procedures;Proliferating;Prostate;Research;response;Rodent;scaffold;self assembly;spheroids;subcutaneous;Surface;System;Technology;Testing;Therapeutic;three dimensional structure;three-dimensional modeling;tool;Touch sensation;triple negative cancer;triple-negative invasive breast carcinoma;tumor;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;two-dimensional;vibration;Woman

PROJECT_TITLE: Characterizing breast cancer invasion and proliferation when co-aggregated with adipocytes in multicellular spheroids created with a custom bioreactor to augment cell-cell connectivity.


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Complementary and Integrative Health;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative Sterile inflammation, induced by cardiac surgery and chronic metabolic disorder, is a serious public health issue and clinical problem, as it can lead to heart failure and death. The goal of this research program is to explore the role of three new molecules/approaches in the regulation of macrophage function ( efferocytosis, polarization) to i.e., minimize such inflammation-triggered heart injury, with the hope of improving heart failure patient survival. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to advancing fundamental knowledge and translational study that will help to reduce the burdens of human disability.

PI_NAMEs: FAN, GUO-CHANG  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute;Address;Anti-Inflammatory Agents;Bacteria;Basic Science;Biology;Cardiac;Cardiac Surgery procedures;Cause of Death;Cells;Cellular Membrane;Cessation of life;Chronic;Clinical;clinical application;Clinical Research;Clinical Trials;Data;Development;Diabetic mouse;disability;Exhibits;extracellular;Genetic;Goals;Heart;Heart failure;heart function;Heart Injuries;Human;Immune;Immune System Diseases;Immunologics;improved;Inflammation;Ischemia;Knock-out;Knowledge;Laboratories;Macrophage;Mediator;member;Membrane;Metabolic Diseases;Mission;Modeling;Molecular;mouse model;Myelogenous;Myocardial Ischemia;Myocarditis;nanodrug;National Institute of General Medical Sciences;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Organ;Outcome;Patients;Phenotype;Play;Principal Investigator;Probiotics;programs;Proteins;Public Health;Recombinants;Regulation;repaired;Reperfusion Therapy;Research;Role;Signal Pathway;sobriety;Sterility;Transgenic Organisms;translational study;Type 2 diabetic;United States National Institutes of Health;Vesicle;vesicular release;Work

PROJECT_TITLE: Novel regulators of macrophage function to repair sterile inflammation-induced heart injury


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Lung cancer screening is poised to substantially reduce lung cancer deaths, however there is evidence of racial disparities in its use. The objective of this project is to investigate the role of patient beliefs, stigma, and medical mistrust, as well as physician implicit bias on racial disparities in lung cancer screening referral and completion. We will conduct this study in a racially- and ethnically-diverse sample of smokers in a large primary care network in New York City.

PI_NAMEs: KALE, MINAL S (contact);SMITH, CARDINALE B

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Address;Adoption;Affect;Agreement;Attitude;Behavioral;Belief;Black Populations;Black race;cancer health disparity;cancer risk;cancer therapy;Cervical;Cessation of life;cigarette smoking;cohort;Colorectal;Communication;computed tomography screening;cultural competence;Data;Development;Discrimination;Disparity;early screening;Eligibility Determination;ethnic difference;ethnic disparity;ethnic diversity;ethnic minority;Evaluation;falls;health belief;health care delivery;health care disparity;health communication;Health system;Healthcare Systems;high risk;Hispanic;Hispanic Populations;implicit bias;improved;Incidence;Informal Social Control;Institute of Medicine (U.S.);Intervention;low dose computed tomography;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Medical;Minority;Minority Groups;Modeling;mortality;multidisciplinary;New York City;Outcome;pain relief;Patients;Physicians;Primary Care;primary care practice;primary care provider;Process;Prostate;provider factors;psychologic;Pulmonary Challenge;racial difference;racial disparity;racial diversity;racial minority;Radiation exposure;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Personnel;response;Risk;Role;Sampling;Scanning;screening;screening disparities;Screening for cancer;screening program;Screening Result;shared decision making;Smoker;Smoking;social culture;social stigma;Stage at Diagnosis;Stigmatization;Survival Rate;Testing;Unconscious State;United States;United States Preventative Services Task Force

PROJECT_TITLE: Investigating the Roles of Patient Beliefs, Stigma, and Physician Implicit Bias on Disparities in Lung Cancer Screening

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(55)]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Public Health Relevance Statement: Aging-related retinal degeneration is a major cause of vision loss in diseases including age-related macular degeneration (AMD). The broad goal of this study is to investigate the role of nuclear receptor RORα in mediating age-related chronic subretinal inflammation and retinal degeneration associated with AMD. The proposed project specifically aims to investigate the mechanisms through which a lipid-sensing nuclear receptor RORα modulates pathologic non-resolving subretinal inflammation to impact retinal health, and finding ways to target RORα and related pathways to resolve persistent inflammation and protect the retina. This work may lead to design of new approaches for alleviating pathologic persistent inflammation and preventing or slowing retinal degeneration in eye diseases.

PI_NAMEs: CHEN, JING  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acceleration;Acute;adenovirus mediated delivery;Affect;age related;Age related macular degeneration;Aging;aging related;Agonist;Blindness;chemokine;Cholesterol;Cholesterol Homeostasis;cholesterol trafficking;Choroid;Choroidal Neovascularization;Chronic;Clinical;Complement;Complement Activation;Complement Factor H;Complex;Cytoprotection;Data;Deposition;design;Disease;Drusen;Dryness;Elderly;Eye;Eye diseases;Fundus;Genes;Genetic Transcription;Genetic Variation;Goals;Grant;Health;Hepatocyte;High Fat Diet;Histology;Homeostasis;Human;human data;Human Genetics;Immune;Immunity;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory marker;Lesion;Ligands;Light;Link;lipid biosynthesis;lipid mediator;Lipids;Liver;LoxP-flanked allele;Macrophage;Mediating;Metabolic;Metabolism;Microglia;Modeling;Morphology;mouse model;Mus;Myelogenous;Natural Immunity;neovascular;Neurodegenerative Disorders;Nonexudative age-related macular degeneration;novel strategies;Nuclear Receptors;Orphan;overexpression;Pathogenicity;Pathologic;Pathway interactions;Photoreceptors;PPAR gamma;prevent;Production;Proliferating;Proteins;public health relevance;receptor;recruit;Retina;retinal damage;Retinal Degeneration;Retinoic Acid Receptor;Risk;Role;Structure of retinal pigment epithelium;Susceptibility Gene;Testing;Thinness;transcription factor;Transcriptional Regulation;uptake;Vision;Wild Type Mouse;Work

PROJECT_TITLE: RORalpha mediates chronic subretinal inflammation associated with AMD

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: Bethany Beach

ORG_NAME: INOVODEL, INC.

ORG_STATE: DE

PHR: PROJECT NARRATIVE Inhaled nitric oxide (“iNO”) has gained significant prominence in treating highly debilitating hypoxic lung failure in newborns, pulmonary arterial hypertension and pulmonary hypertension associated with pulmonary diseases. However, the market for iNO is limited due to the cost, complexity, and safety of the dominant tank-based delivery systems. The goal of this investigation is to develop a simpler, safer, compact, portable and more versatile means of generating and delivering iNO, offering the promise of lower cost and better treatment for existing iNO therapy, and the potential for a significant expansion of the patient population who can safely and effectively benefit from iNO therapy.

PI_NAMEs: LESSING, GARY  (contact)

PROJECT_TERMS: Accident and Emergency department;Acute;Admission activity;Adult;Affect;Air;Alabama;analog;antagonist;Anti-Hypertensive Agents;antimicrobial;Atmosphere;Biological Availability;Blood Circulation;Blood Vessels;Cessation of life;chemical reaction;Chemicals;Child;Chronic;commercialization;Compensation;Complex;Conduct Clinical Trials;Consumption;cost;curative treatments;detector;Developed Countries;Development;Device or Instrument Development;Devices;Diagnosis;Disease;Dose;Electronics;Endothelin;experience;Extracorporeal Membrane Oxygenation;FDA approved;Formulation;Gases;Generations;Goals;Growth;Health;Healthcare Systems;Hospitals;improved;In Vitro;Infant;Infection;Inflammation;Inhalation;inhaled nitric oxide;inhibitor;injury and repair;innovation;Intensive Care Units;Intervention;Investigation;Licensing;Life;life span;Lung;Lung Diseases;lung failure;lung hypoxia;Marketing;Measurement;Medical;Medical center;Methods;monitoring device;mortality;Newborn Infant;Nitric Oxide;Nitrogen;Nitrogen Dioxide;novel;Operating Rooms;Oxygen;Patient Admission;patient home care;patient population;Patients;Persons;Pharmaceutical Preparations;Phase;phosphodiesterase V;portability;premature;prevent;Process;Prostaglandins I;prototype;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary artery structure;Pulmonary Hypertension;Pump;Quality of life;Reaction;right ventricular failure;Safety;seal;sensor;Shortness of Breath;Signaling Molecule;Site;supplemental oxygen;Syringes;System;Systemic blood pressure;Technology;Testing;Therapeutic;Time;Universities;Vascular resistance;Vasodilator Agents;voltage

PROJECT_TITLE: Chemical-based Nitric Oxide Gas-generating Drug Device for the Treatment of Pulmonary Hypertension


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Nutrition;Physical Activity

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Genetic variation in the atrial natriuretic peptide (ANP) hormone, an important regulator of cardiometabolic health, may contribute to the burgeoning cardiometabolic disease burden in the United States. Micro-RNA- 425 (miR-425), a known negative regulator of ANP, may regulate the response of ANP to metabolic perturbations, and in turn, limit its numerous beneficial cardiometabolic effects. This study will assess the impact of high and low ANP genotype on the regulation of cardiometabolic health and provide the mechanistic basis for novel RNA-based therapeutics targeting the ANP-miR-425 axis for the treatment and control of the snowballing cardiometabolic disease burden in the United States.

PI_NAMEs: ARORA, PANKAJ  (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: 3' Untranslated Regions;Adipocytes;Adult;Age;Alleles;Atrial Natriuretic Factor;Binding;Biological;Black Populations;Blood;blood glucose regulation;Blood Pressure;Blood Vessels;Body mass index;Brown Fat;burden of illness;Cardiac;Cardiac Myocytes;Cardiometabolic Disease;cardiometabolism;Data;Development;Diabetes Mellitus;Diet;Energy Metabolism;Enrollment;Ensure;Exercise;exercise intervention;Exercise Test;Expenditure;Fatty acid glycerol esters;Female;Frequencies;Gene Expression;Genes;Genetic Carriers;genetic variant;Genetic Variation;Genotype;Glucose;Glycerol;Health;Homeostasis;Hormones;Hour;Human;Hyperinsulinism;improved;In Vitro;in vivo;Indirect Calorimetry;Individual;innovation;insight;Insulin;Insulin Resistance;insulin sensitivity;lipid biosynthesis;Lipolysis;Low Prevalence;Mediating;Messenger RNA;Metabolic;Metabolic syndrome;MicroRNAs;Minor;Natriuresis;Natriuretic Peptides;Nonesterified Fatty Acids;novel;novel therapeutics;Obesity;Oral;Participant;Pathway interactions;Phenotype;Physiological;Plasma;Population;prevent;primary outcome;Production;Protocols documentation;Regulation;response;Rest;Risk;RNA;Role;salt intake;Sampling;Skeletal Muscle;Specificity;Standardization;System;Testing;Therapeutic;therapeutic RNA;therapeutic target;Thinness;United States;Whole Blood;Work

PROJECT_TITLE: Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Nutrition;Obesity

ORG_CITY: ATLANTA

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

PHR: Project Narrative My research is focused on understanding the role of P311, a small protein that regulates the development, plasticity (switch among different types), and function of different types of fat cells (white, beige and brown). The goal of this research is to understand how this protein controls fat cells to influence the development of related metabolic diseases, such as diabetes. Knowing how P311 works can help us to develop novel strategies towards developing treatments for obesity and associated metabolic irregularities.

PI_NAMEs: BADRI, KAMESWARA RAO (contact)

PROJECT_TERMS: Ablation;adipocyte biology;adipocyte differentiation;Adipocytes;Adipose tissue;Affect;Age;age group;Apoptosis;Autophagocytosis;Binding;Biochemical;Biological Assay;Biology;blood glucose regulation;Body mass index;Brown Fat;Carrier Proteins;Cell Physiology;Cellular biology;Chronic Disease;Clinical;conditional knockout;CRISPR/Cas technology;Cues;Development;Diabetes Mellitus;digital;Disease;Epidemic;Equipment;Event;exhaust;fasting glucose;Fatty acid glycerol esters;Functional disorder;Funding;Gene Modified;Generations;Genetic;Glucose;glucose transport;Glucose Transporter;GLUT 4 protein;glycemic control;Goals;Health;Heart Diseases;Heterogeneity;Homeostasis;Hyperglycemia;Hyperglycemic Mice;Hyperplasia;Hypertension;Hypertrophy;imaging modality;Immunoassay;improved;Infiltration;innovation;Insulin Resistance;Kinetics;Knock-out;Knockout Mice;Link;lipid biosynthesis;Lipids;Lipolysis;Location;Macrophage;Malignant Neoplasms;man;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Metabolism;Methods;Molecular;Molecular Biology;Mus;nano-string;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;obesity treatment;Pathology;Phenotype;Play;Population;PPAR gamma;precursor cell;Primary Cell Cultures;Principal Investigator;Proteins;Regulation;Reporter;Research;Risk;Role;Skeletal Muscle;stable isotope;subcutaneous;Technology;Testing;Therapeutic;Tissue Expansion;Transgenic Animals;uncoupling protein 1;Vascular Smooth Muscle;Work

PROJECT_TITLE: P311 mediated adipogenesis, adipocyte plasticity and metabolic regulation


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pregnancy;Social Determinants of Health;Women's Health Research

ORG_CITY: BLOOMINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: 8. Project Narrative Young women between the ages of 18 and 22 have high rates of undesired pregnancy. I propose to use the semi-structured interviews associated with a large, longitudinal survey dataset (the Relationship Dynamics and Social Life study) to investigate the role of pregnancy desires, intimate relationship behavior, and contraceptive use in young women’s experiences with pregnancy.

PI_NAMEs: BARBER, JENNIFER S. (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: 19 year old;Affect;Age;avoid pregnancy;Behavior;Birth;Black race;Books;Categories;Characteristics;Child;Clinic;comparison group;Computer software;Contraception Behavior;Contraceptive Usage;Data;Data Set;Demographer;design;ethnoracial minority;experience;falls;Funding;Goals;Hazard Models;health inequalities;Human Rights;improved;Individual;innovation;Intervention;Interview;journal article;Licensing;Life;Life Cycle Stages;Longitudinal Surveys;Manuscripts;Measures;Methods;Modeling;Motivation;Multiple Partners;National Institute of Child Health and Human Development;neglect;older women;Outcome;Pathway interactions;Persons;post pregnancy;Poverty;Pregnancy;Pregnancy Rate;pregnant;prospective;Public Assistance;Public Health;Race;reproductive;Research;Research Design;Respondent;response;Risk;Role;Sampling;Series;social;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Status;socioeconomics;Statistical Models;Structure;Subgroup;Surveys;Techniques;theories;Time;trait;transition to adulthood;United States Dept. of Health and Human Services;Woman;young woman

PROJECT_TITLE: Undesired Pregnancies during the Transition to Adulthood

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Genetics;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Many adult human diseases, both wasting/degenerative diseases and cancer, are linked to dysfunction of the adult tissue-specific stem cells that are normally responsible for tissue maintenance, repair and renewal. These adult stem cells are the culmination of developmental programs initiated in the embryo. We will investigate how proper embryonic development of these cells impacts their maintenance and function during adulthood.

PI_NAMEs: ADAMS, PETER D. (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acceleration;Adult;adult stem cell;Aging;Apoptosis;Back;Birth;Cell Aging;Cell Maintenance;Cells;Cessation of life;combat;Compensation;Data;Defect;Degenerative Disorder;Deposition;Development;developmental disease;Disease;DNA Damage;Embryo;Embryonic Development;embryonic stem cell;Enhancers;Environmental Exposure;epigenetic memory;Epigenetic Process;exhaust;exhaustion;Exhibits;Fetal Development;Frequencies;Functional disorder;Genes;Genetic;Genetic Transcription;Hair;Histone H3.3;Histones;human disease;Hypopigmentation;Image;Impairment;in utero;In Vitro;in vivo;Knock-out;Knockout Mice;late life;Link;Maintenance;Malignant Neoplasms;Mediating;melanoblast;melanocyte;Melanoma;Mesenchymal;Molecular;Molecular Chaperones;multimodality;Mus;neoplastic;Neural Crest;Newborn Infant;Oncogenes;Pathway interactions;PAX3 gene;Phenotype;Pigmentation physiologic function;premature;Process;programs;Proliferating;promoter;Proto-Oncogene Protein c-kit;repaired;Role;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Stem Cell Development;stem cell exhaustion;stem cell function;stem cell population;stem cells;Stimulus;Stress;telomere;Testing;Therapeutic Intervention;tissue degeneration;Tissues;transcription factor;Transcriptional Regulation;transcriptomics;Translating;transmission process;Variant;wasting;Wild Type Mouse

PROJECT_TITLE: Mechanisms that couple irregular development of fetal melanoblasts to premature exhaustion of adult melanocyte stem cells

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ORG_CITY: GAINESVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative BET proteins are of great interest to public health for their involvement in: 1) different types of cancer such as lung, breast, and prostate; and 2) viral infection. Therapeutic design strategies against these diseases have targeted BET proteins in the last decade but failed due to toxicity and drug resistance issues. This project aims to characterize a promising alternative region of BET proteins to lay the foundation for novel therapeutic strategies that will overcome current limitations.

PI_NAMEs: PEREZ, ALBERTO  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Affinity;Bayesian Analysis;Binding;Binding Proteins;Bioinformatics;bioinformatics tool;Biology;Breast;Bromodomain;cancer type;Cells;Chemicals;Chromatin;Clinical Trials;Communities;Competitive Binding;Complex;computational pipelines;computerized tools;Computing Methodologies;Data;design;Development;Disease;Docking;driving force;Drug resistance;Drug Targeting;Epigenetic Process;Epitopes;experimental study;flexibility;Foundations;Genes;Goals;Grant;Hallucinations;Heart;Hematologic Neoplasms;immunoregulation;improved;Inflammatory;inhibitor;interest;Light;Lung;Machine Learning;member;Modeling;Molecular Conformation;molecular dynamics;Nature;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenes;Outcome;Pathologic;Pathology;Peptide Library;peptide structure;Peptides;Pharmaceutical Preparations;Physics;prevent;Prostate;protein aminoacid sequence;Protein Family;protein protein interaction;Proteins;Public Health;Rapid screening;Reporting;Research;Role;Sampling;simulation;Solid Neoplasm;Specificity;structural biology;Structure;Structure-Activity Relationship;success;System;Tertiary Protein Structure;Testing;Therapeutic;Therapeutic Agents;Tissues;Toxic effect;Virus;Virus Diseases;Work

PROJECT_TITLE: Targeting the ET domain of BET proteins: specificity and selectivity

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative This project aims to analyze the role of VAV1-MYO1F a recurrent activating genetic alteration driving activation of the guanine nucleotide exchange factor VAV1 in Peripheral T-cell Lymphomas (PTCL). To dissect the role of the recurrent VAV1-MYO1F fusion, we will use a newly developed genetically engineered mouse model of lymphoma and characterize these tumors using a combination of molecular pathology and genomic profiling tools. Elucidation of the specific mechanisms mediating the oncogenic effects of VAV1-MYO1F will provide important novel insight on the pathogenesis of peripheral T-cell lymphomas and point to novel targets to be tested in experimental therapeutics.

PI_NAMEs: PALOMERO, TERESA  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acceleration;Adaptor Signaling Protein;Affect;Alleles;Automobile Driving;C-terminal;Candidate Disease Gene;CD4 Positive T Lymphocytes;Cell Compartmentation;cell motility;Cells;Clinical;Clonal Expansion;cytokine;Cytokine Signaling;Cytoskeletal Modeling;Development;Diagnosis;Disease Progression;DNA Sequence Alteration;GATA3 gene;Gene Modified;Genetic;Genetic Transcription;Genetically Engineered Mouse;genomic profiling;Genomics;Goals;Guanine Nucleotide Exchange Factors;hematopoietic tissue;high risk;Histology;Human;Immune Evasion;in vivo;individualized medicine;Infiltration;insertion/deletion mutation;insight;Investigational Therapies;Knock-in Mouse;Lead;Lymphoma;Lymphomagenesis;Malignant - descriptor;MAP Kinase Gene;MAPK8 gene;Mature T-Lymphocyte;Mediating;migration;molecular pathology;mouse model;Mus;Mutation;Mutation Analysis;Natural Killer Cells;Non-Hodgkin's Lymphoma;novel;nuclear factors of activated T-cells;Oncogenes;Oncogenic;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Pattern;Peripheral;Pharmacotherapy;Point Mutation;polarized cell;Pre-Clinical Model;premalignant;Prognosis;programs;Proliferating;Protein Tyrosine Kinase;Proto-Oncogenes;Receptor Activation;Recurrence;response;RHOA gene;Role;S100A7;Signal Pathway;Signal Transduction;Specific qualifier value;Structure of germinal center of lymph node;T cell differentiation;T-Cell Activation;T-Cell Lymphoma;T-Cell Proliferation;T-Cell Receptor;T-Cell Transformation;T-Lymphocyte;targeted sequencing;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;tool;transcriptome sequencing;tumor;tumor initiation;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumor-immune system interactions;VAV1 gene

PROJECT_TITLE: Role and Mechanisms of VAV1 alterations in Peripheral T-cell Lymphomas

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE The research outlined in this proposal seeks to identify and define a non-canonical inhibitory circuit from the retina to the brain. Though all light information relayed from the retina to the brain was thought to be excitatory, our data suggests that a subset of the melanopsin-expressing, intrinsically photosensitive retinal ganglion cells release the inhibitory neurotransmitter GABA. The presence of an inhibitory circuit from the eye to the brain necessitates a re-evaluation of the existing models for how light information is transmitted from the eye to the brain to influence behavior, and could lead to a better understanding of how light influences our sleep and daily activity.

PI_NAMEs: SCHMIDT, TIFFANY M. (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Anatomy;Area;Axon;Behavior;behavior influence;Brain;Brain region;Cells;Characteristics;circadian;Conscious;Data;Electrophysiology (science);Evaluation;experimental study;Eye;gamma-Aminobutyric Acid;ganglion cell;Ganglion Cell Layer;Glutamate Decarboxylase;Glutamates;Human;IGL@ gene cluster;Immunohistochemistry;immunoreactivity;Knock-out;Light;Literature;Maps;melanopsin;Modeling;mouse genetics;Mus;neurotransmission;neurotransmitter release;Neurotransmitters;Optic Nerve;Organism;Oryctolagus cuniculus;patch clamp;Pathway interactions;Peptides;Physiology;Population;postsynaptic;prevent;Pupil light reflex;Research;Retina;Retinal Ganglion Cells;Role;Signal Transduction;Sleep;Specific qualifier value;Subconscious;Testing;Time;transmission process;Viral;Visual;Visual Perception;Visual System;Work

PROJECT_TITLE: Non-canonical GABAergic Pathways in the Visual System

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome

ORG_DEPT: DERMATOLOGY

PHR: ATLAS OF REGULATORY VARIANTS IN DISEASE (ARVID)  Project Narrative Inherited risk for common diseases arises from multiple genetic variants, most of which reside in DNA sequences that may dysregulate gene expression in a way that predisposes to illness. An atlas of functionally validated disease variants, the genes they control, and the proteins whose binding they alter will help understand, predict, and prevent common diseases. 1

PI_NAMEs: KHAVARI, PAUL  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Affect;Alleles;Alzheimer's Disease;ATAC-seq;Atlases;Binding;Biochemical;Biological Assay;Categories;Cell Lineage;cell type;Cells;Chromatin;chromatin immunoprecipitation;Chronic Obstructive Pulmonary Disease;Clinical;Communities;cost;Data;data resource;Detection;Disease;disorder risk;DNA;DNA Binding;DNA Sequence;DNA-Protein Interaction;Enhancers;epigenomics;Gene Expression;gene-editing approach;Genes;genetic variant;genome resource;genome wide association study;genome-wide analysis;Genomics;Genotype-Tissue Expression Project;Hereditary Disease;Human;human disease;improved;In Situ;indexing;Individual;Inherited;insight;interest;Ischemic Stroke;Link;Maps;Mass Spectrum Analysis;Mediating;Methods;mortality;Myocardial Ischemia;National Human Genome Research Institute;Nature;Non-Insulin-Dependent Diabetes Mellitus;Nucleotides;Pathogenesis;Pathogenicity;prevent;promoter;Proteins;Proteome;Proteomics;Quantitative Trait Loci;Regulator Genes;Reporter;Risk;RNA;Single Nucleotide Polymorphism;Speed;Tissues;transcription factor;Untranslated RNA;Variant;years of life lost

PROJECT_TITLE: Atlas of Regulatory Variants in Diseases (ARVID)


ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Hemorrhage bears a significant burden to public health. Our novel device, which employs microscale electrical fields, is a promising therapeutic strategy that has been demonstrated to accelerate blood clot formation and may represent in a new paradigm to treat bleeding in trauma, surgery, and patients with blood diseases. In this proposed research, I will investigate the basic science mechanisms of this phenomenon and its potential as an innovative therapeutic hemostatic agent.

PI_NAMEs: VITAL, EUDORAH  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acceleration;Address;Adhesives;Adverse effects;Appearance;Bandage;Basic Science;Behavior;Biological;Biological Products;Biological Sciences;Biomedical Engineering;Blood;Blood coagulation;Blood Vessels;Cell Adhesion Molecules;Cells;Chemical-Induced Change;Chemicals;Chemistry;Clinical;Communication;cost effective;Data;Deposition;design;Development Plans;Device or Instrument Development;Devices;Diameter;Disease;electric field;Electrical Engineering;Electronics;Electrosurgery;Endothelial Cells;Endothelium;Engineering;Environment;Exposure to;Fibrin;Fibrinogen;Fostering;Foundations;Future;Generations;Geometry;Goals;Health;Hematological Disease;Hematology;Hemorrhage;Hemostatic Agents;Hemostatic function;Human;Immune;improved;In Vitro;in vitro Model;in vivo;in vivo Model;infection risk;innovation;insight;Intervention;Investigation;Kinetics;Laboratories;Lead;Literature;Measures;Mechanics;Medical;Mentorship;meter;Methods;microelectronics;Microfluidics;Microscopy;microsystems;Modality;Modeling;Morbidity - disease rate;mortality;nanofabrication;Nature;new technology;novel;novel strategies;Operative Surgical Procedures;Paper;Patients;pharmacologic;Physicians;Physiology;polymerization;Polymers;Public Health;Publishing;Reactive Oxygen Species;Research;Resources;response;Scientist;targeted treatment;Techniques;Temperature;Therapeutic;therapy development;Thrombin;Thromboplastin;Time;Tissue Preservation;Tissues;tool;Training;Trauma;Up-Regulation;Vascular Endothelium;voltage;Work;wound

PROJECT_TITLE: A New Paradigm to Treat Bleeding by Augmenting Hemostasis via Microscale Electrical Fields

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F10C-A(20)]


ORG_CITY: PORTLAND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Leishmania and related kinetoplastid parasites cause devastating diseases worldwide that afflict millions of individuals. Understanding how specific parasite organelles and surface proteins mediate transmission, infection and virulence is critical to controlling these diseases. This project will focus on the role of the flagellar membrane in both the insect vector and infectious mammalian forms of the parasite life cycle.

PI_NAMEs: LANDFEAR, SCOTT M (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Affinity Chromatography;Back;Biochemical;Biological;Biological Process;Biology;Cells;cohort;Collection;Cytokinesis;Cytoskeletal Proteins;Data;Dedications;Destinations;Disease;disorder control;Environment;extracellular;extracellular vesicles;Flagella;frontier;Glucose Transporter;hemoflagellate;Immune response;Immunity;In Vitro;in vivo;Individual;infancy;Infection;Insect Vectors;Insecta;Integral Membrane Protein;knockout gene;Knowledge;Leishmania;Leishmania mexicana;Life Cycle Stages;Mass Spectrum Analysis;Mediating;Membrane;Membrane Protein Traffic;Membrane Proteins;Modeling;Molecular;Motility;Mus;mutant;novel;Organelles;Parasites;parasitism;Parasitology;particle;Partner in relationship;Pathway interactions;Persons;Phenotype;Phlebotominae;Play;Proteins;Protozoa;Research;Role;Sorting;Surface;Testing;Time;trafficking;transmission process;Trypanosoma brucei brucei;Trypanosoma cruzi;Vacuole;vector;Virulence

PROJECT_TITLE: Function and Trafficking of Flagellar Membrane Proteins in Leishmania mexicana

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(02)]