NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Mutant oncogenes are central to the initiation, progression, and response to therapy of many human cancers. Yet, the significance of mutant oncogene zygosity whereby changes in the dosage and stoichiometry of oncogenic driver mutations leads to selective growth advantages and therapeutic vulnerabilities remains largely unknown. To overcome this challenge, we propose an innovative and multidisciplinary translational genomic approach to establish the prevalence, evolutionary origin, biological, and therapeutic impact of changes in mutant oncogene zygosity to optimize the treatment of advanced cancer patients.

PI_NAMEs: CHANDARLAPATY, SARAT  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;Alleles;Allelic Imbalance;Biochemical;Biological;Biological Markers;Biological Process;Biology;BRAF gene;Breast Cancer Patient;cancer genome;cancer initiation;Cancer Patient;cancer type;carcinogenesis;cell free DNA;Cell Separation;Cells;cellular engineering;Chronology;Clinical;clinical application;clinical sequencing;Clinical Trials Design;clinically significant;co-clinical trial;cohort;colon cancer patients;Communities;Computing Methodologies;cost;Data;Dependence;Diagnosis;Disease Progression;DNA copy number;dosage;driver mutation;ERBB2 gene;ESR1 gene;Estrogen Receptors;Evolution;FDA approved;fitness;flexibility;Fostering;functional genomics;gain of function;gain of function mutation;Genes;Genetic;genetic evolution;Genomic approach;Genomics;Goals;Growth;Heterozygote;Human;innovation;insight;Institution;Investigation;KRAS oncogenesis;KRAS2 gene;KRASG12D;leukemia;Link;Loss of Heterozygosity;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metastatic breast cancer;Methods;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinases;Molecular;multidisciplinary;mutant;Mutation;Neoplasm Metastasis;novel therapeutic intervention;Oncogenes;Oncogenic;Pathway interactions;patient derived xenograft model;Patients;Phenotype;Physicians;Population;precision oncology;predictive marker;Prevalence;prognostic;Property;prospective;Proteins;Receptor Gene;Research;Resources;response biomarker;Role;Sampling;single cell analysis;stoichiometry;System;Testing;Therapeutic;Time;translational genomics;treatment optimization;treatment response;tumor;Tumor Biology;tumor progression;Tumor Suppressor Proteins

PROJECT_TITLE: Defining the impact of mutant oncogene zygosity

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Sarcopenia;Substance Misuse

ORG_CITY: CLEVELAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: The prevalence of alcohol use disorders and related tissue injuries continues to increase in the United States and contributes to a high mortality and morbidity. The proposed studies will address one of the frequent consequences of alcohol use that is noted in patients with alcoholic liver disease, skeletal muscle loss or sarcopenia. In addition to the potential for development of mechanism based therapies, the proposed studies will also help the applicant become an independent physician scientist in the field of alcoholic liver disease.

PI_NAMEs: WELCH, NICOLE  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Address;Adverse effects;alcohol consequences;Alcohol consumption;alcohol exposure;alcohol response;alcohol testing;alcohol use disorder;Alcoholic Liver Cirrhosis;Alcoholic Liver Diseases;Alcohols;alpha ketoglutarate;Ammonia;ATAC-seq;Autophagocytosis;Award;biobank;Biological Assay;Biopsy Specimen;Career Choice;career development;Chronic Disease;Cirrhosis;Citric Acid Cycle;Clinical;clinical training;clinical translation;clinically significant;Collaborations;Complex;Data;Degradation Pathway;Development;effective therapy;Environment;Ethanol;experimental study;Exposure to;Fellowship;Foundations;FRAP1 gene;Funding;gain of function;Genetic Transcription;Goals;Heart failure;Hepatic;hepatic ureagenesis;HIF1A gene;Human;Hyperammonemia;Hypoxia;Hypoxia Inducible Factor;Impairment;In Vitro;in vivo;inhibitor;Institution;Kidney Failure;Label;Link;Liver diseases;liver transplantation;loss of function;lung failure;Mediating;Mentors;Metabolic;metabolic abnormality assessment;mitochondrial dysfunction;Molecular;Molecular Target;Morbidity - disease rate;mortality;Mus;Muscle;Muscle Fibers;muscle form;Muscle Proteins;muscle strength;Muscular Atrophy;National Institute on Alcohol Abuse and Alcoholism;novel;Ohio;Outcome;Oxygen;Patients;Phenotype;Phosphotransferases;Physicians;Physiological;Pilot Projects;Post-Translational Protein Processing;Pre-Clinical Model;preservation;Prevalence;programs;Protein Biosynthesis;proteostasis;proteostasis loss;Reporter;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;response;sarcopenia;Scientist;Signal Transduction;Signaling Molecule;Skeletal Muscle;skeletal muscle wasting;Stress;targeted treatment;Testing;therapeutically effective;Time;tissue injury;Tissues;Training;transcription factor;Translational Research;United States;uptake;Validation;Work

PROJECT_TITLE: Mechanisms of HIF1 alpha mediated dysregulated skeletal muscle proteostasis in alcoholic liver disease

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: TAMPA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Alzheimer’s disease (AD) is the most common form and devastating dementia. Currently there are no effective approaches to specifically target and prevent AD pathogenesis. In contrast to known strategies, this work is unique because it will identify molecules with novel mechanism that recognize monomeric Aβ helix and shift Aβ conformation into off-pathway of pathogenic progression. As such, these new molecular probes could prevent and remove Aβ aggregates and plaques without decreasing the total Aβ level.

PI_NAMEs: CAI, JIANFENG  (contact);CAO, CHUANHAI

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: abeta accumulation;abeta oligomer;AD transgenic mice;Aducanumab;Affinity;alpha synuclein;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer’s disease biomarker;Amyloid beta-Protein;Amyloid Proteins;Amyloidosis;analog;behavior test;beta pleated sheet;Binding;Biocompatible Materials;Biological Assay;Brain;cell growth;Cells;Chemicals;Computer Models;cost;cytotoxicity;Dementia;Dendrites;Deposition;design;Development;Diabetes Mellitus;Disease;disorder prevention;Enzyme Inhibitor Drugs;Equilibrium;Etiology;Excision;FDA approved;functional group;Goals;Growth;Huntington Disease;improved;In Vitro;in vitro Assay;in vivo;innovation;insight;Intervention;Investigation;islet amyloid polypeptide;Kinetics;Lead;Libraries;Memory;Microglia;mimetics;Molecular Conformation;Molecular Probes;Molecular Weight;Monoclonal Antibodies;monomer;mouse model;Mus;Nature;neurodegenerative dementia;neuronal survival;Neurons;neurotoxic;neurotoxicity;novel;novel therapeutic intervention;novel therapeutics;Outcome;Parkinson Disease;Pathogenesis;Pathogenicity;Pathway interactions;Pattern;Peptide antibodies;Peptide Hydrolases;Peptides;peptidomimetics;Phagocytosis;Physiological;Plague;Play;Predisposition;prevent;Prevention;Process;Production;protein aggregation;Protocols documentation;rational design;Research;Role;Senile Plaques;Series;Side;side effect;Signal Pathway;Structure;Surface;tau Proteins;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;Toxic effect;virtual;Western Blotting;Work

PROJECT_TITLE: Recognition of Abeta monomeric helix

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-V(02)M]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Experiences of racial discrimination are traumatic and represent a ubiquitous reality for Black youth that can have lasting psychological consequences that undergird the profound racial health disparities within the United States. Bourgeoning psychological research has pointed to the immediate need to elucidate how racism-related trauma affects mental health outcomes and has demonstrated the importance of illuminating culturally relevant factors, including racism-related vigilance and racial identity, in understanding the link between racism-related trauma and mental health outcomes. This K23 will equip the investigator with critical skills needed to identify such developmental factors and pathways and integrate them into interventions that promote resiliency and reduce mental health disparities among Black youth.

PI_NAMEs: BERNARD, DONTE  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Acceleration;Address;Affect;African;Anxiety;Applications Grants;Attention;Behavior;Black race;career;Caregivers;child and adolescent victimization;Child Traumatic Stress;Chronic;Clinical;Cognitive;Competence;Cues;Data;design;Development;Dimensions;Educational workshop;Ensure;Environment;ethnic minority;Evaluation;Event;Evidence based intervention;experience;Exposure to;Foundations;Funding;Future;Goals;Health;Health Disparities Research;health disparity;improve minority health;improved;Individual;insight;Intervention;Interview;Knowledge;Lead;Life Cycle Stages;Link;Longitudinal cohort;Longitudinal Studies;Manuals;Measurement;Mediating;Mental Depression;Mental Health;Mental health promotion;Mentors;Mentorship;Methods;minority communities;Mission;National Institute of Mental Health;National Institute on Minority Health and Health Disparities;Negative Valence;novel;Outcome;Pathway interactions;Physiological;Population;Positioning Attribute;Post-Traumatic Stress Disorders;programs;promote resilience;psychologic;psychological distress;psychological outcomes;psychosocial;Public Health;Qualitative Methods;Race;racial discrimination;racial health disparity;racial identity;racial minority;racism;Reduce health disparities;Reporting;Research;Research Methodology;Research Personnel;resilience;response;Risk Reduction;Role;rumination;Scientist;Site;skill acquisition;skills;stressor;symposium;Symptoms;System;Taxes;therapy development;Time;Training;Trauma;traumatic event;traumatic stress;United States;Universities;vigilance;Washington;Youth

PROJECT_TITLE: Novel Mixed-Method Research and Training in Racism-Related Trauma and Mental Health Disparities Among Black Youth


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: NARRATIVE Genetic screens teach us how genetic elements in our bodies’ cells relate to normal health, disease, and the way drug therapies work. Recently, powerful genetic screening technologies producing rich data about the internal state of cells have been developed, but they are expensive and can only be used to study a handful of genetic elements at a time. Here, we propose to develop and demonstrate a method that can test tens of thousands of genetic elements at once by focusing on only a select few key aspects of the cell state.

PI_NAMEs: BLAINEY, PAUL CLARK (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Adoption;Affect;anti-cancer research;Bar Codes;base editing;Behavior;Biological Assay;Biology;Cell Line;Cell model;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complementary DNA;cost;CRISPR interference;CRISPR screen;CRISPR-mediated transcriptional activation;Custom;Data;Disease;Drug resistance pathway;Educational process of instructing;Emulsions;Engineering;Ensure;Epithelium;experimental study;Expression Profiling;fitness;functional genomics;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene panel;Gene Pool;Generations;Genes;genetic association;genetic element;Genetic Screening;genome wide screen;genome-wide;Genomic approach;Genomics;Goals;Guide RNA;Health;indexing;interest;Knock-out;Libraries;Link;Malignant Neoplasms;Mammary Gland Parenchyma;MCF10A cells;Mesenchymal;Messenger RNA;Methods;Modality;Monitor;Nature;novel;Pathway interactions;Performance;Pharmacotherapy;prime editing;Proliferating;Publishing;Reaction;Reagent;Regulator Genes;Reproducibility;Resources;Reverse Transcriptase Polymerase Chain Reaction;RNA Sequences;Running;Sampling;screening;Screening Result;Signal Transduction;solution hybridization;Technology;Testing;Time;Transcript;transcriptome sequencing;wasting;Work

PROJECT_TITLE: Stitch-seq for genome-wide pooled genomic screening with RNA-seq readout


ADMINISTERING_IC: EB

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative This research will enable us to study real-time biological processes at the cellular level noninvasively in deep regions (~2 mm) of living systems. The proposed new method for aberration sensing and correction in highly scattering tissues will improve the quality of the excitation focus in multiphoton microscopy, thus, will enhance the signal strength and spatial resolution in deep-tissue imaging. In the long term, this research will allow scientists to investigate the underpinnings of brain functions and complex behaviors, as well as the mechanism of immune response in live animals.

PI_NAMEs: CHEN, XI  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: 3-Dimensional;Acute;adaptive optics;Adult;Animals;Attenuated;Behavior;Biological Process;Biomedical Research;Brain;Cancer Biology;career;Cell Communication;cell motility;cellular imaging;Complex;confocal imaging;Dendritic Cells;Deterioration;Elasticity;Fluorescence;fluorophore;Foundations;Goals;Heating;Image;Imaging Device;Immune response;Immunology;improved;in vivo;Interference Microscopy;Lasers;Light;Lighting;lymph nodes;Measurement;Measures;Methods;Microscope;Microscopy;multi-photon;multiphoton imaging;multiphoton microscopy;Mus;Muscle;nanoscale;Neurons;Neurosciences;new technology;Noise;non-invasive system;novel;Operative Surgical Procedures;Optical Methods;Organism;Penetration;Phase;Photobleaching;photomultiplier;Photons;Predisposition;Procedures;Process;programs;reconstruction;Research;Resected;Resolution;Scanning;Scientist;Signal Transduction;Slice;Source;Specificity;Specimen;Speed;submicron;System;T-Lymphocyte;Techniques;Technology;Thalamic structure;three photon microscopy;Time;Tissue imaging;tissue phantom;Tissue Sample;Tissues;tool;Tube;two-photon;Zebrafish

PROJECT_TITLE: High-throughput closed-loop direct aberration sensing and correction for multiphoton imaging in live animals


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative My research program is devoted to understanding fundamental DNA repair mechanisms and their influence on cancer etiology and response to therapy. We will continue to approach these central questions by utilizing unique systems that we have developed to investigate the molecular events underlying (1) DNA damage recognition, (2) the influence of chromatin on DNA repair mechanism, and (3) response to targeted agents. These pursuits will provide insights into adaptive responses of homologous recombination deficient cancers to DNA damaging therapies.

PI_NAMEs: GREENBERG, ROGER A (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Affect;Affinity;ataxia telangiectasia mutated protein;ATM deficient;ATM Gene Mutation;BARD1 gene;Binding;Binding Proteins;Biochemical;BRCA mutations;BRCA1 gene;Cancer Etiology;candidate identification;cell type;Cells;Chromatin;Clinical;Collaborations;Complex;Deubiquitinating Enzyme;dimer;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Replication Damage;DNA replication fork;Elements;enzyme activity;Etiology;Event;Excision;Functional disorder;gene network;Generations;Genetic;Genetically Engineered Mouse;genome integrity;Germ-Line Mutation;Goals;Hematopoietic stem cells;Hereditary Breast and Ovarian Cancer Syndrome;histone modification;Histones;homologous recombination;homologous recombination deficiency;Hydrolysis;Hypersensitivity;in vivo;insight;Investigation;Knockout Mice;Link;loss of function mutation;Lysine;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;member;Methodology;Modality;Modification;Molecular;Monitor;Mutation;Nonhomologous DNA End Joining;novel;Nucleosomes;Null Lymphocytes;Other Genetics;Outcome;Pennsylvania;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Post-Translational Protein Processing;Predisposition;prevent;programs;Proteins;Proteome;Proteomics;Recombinants;reconstitution;Research;Resistance;response;Role;Single-Stranded DNA;Site;stem cell function;structural biology;Structure;Surface;System;targeted agent;Testing;Therapeutic;Topoisomerase-I Inhibitor;treatment response;Ubiquitin;ubiquitin isopeptidase;Western Blotting;Work

PROJECT_TITLE: The RAP80-BRCC36 Deubiquitinating Complex in DNA Repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-C(02)M]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hematology;Neurosciences;Prevention;Stroke

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Ischemic stroke affects about 700,000 Americans each year, but the source of blood clot that caused the stroke is unknown in about a third of cases. Determining where the embolism originated from and whether blood clot still remains there directly impacts treatment decisions in preventing a second stroke. This proposal aims to apply PET-CT imaging with a new molecular probe that can detect blood clots in the heart, arteries, or veins, and to determine if it can effectively identify the source of ischemic stroke in patients.

PI_NAMEs: CARAVAN, PETER D (contact);SOSNOVIK, DAVID E

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Acute;acute stroke;Address;Affect;Age;American;aortic arch;Arterial Fatty Streak;Arteries;Atrial Fibrillation;auricular appendage;Award;Binding;Biological;Blood coagulation;Brain;Cardiac;Carotid Arteries;Carotid Atherosclerotic Disease;Chest;Clinical Research;Contralateral;cryptogenic stroke;deep vein;Deep Vein Thrombosis;Defect;Detection;dosimetry;embolic stroke;Embolism;Etiology;Event;Exclusion;Fibrin;Foundations;Functional disorder;Gold;Head;healthy volunteer;Heart;Hospitalization;Hour;Image;imaging study;Incidence;indexing;insight;invention;Ischemia;Ischemic Stroke;Left;Lower Extremity;Lytic;Magnetic Resonance Imaging;manufacture;Measures;Mechanics;Molecular Probes;Morbidity - disease rate;mortality;Neck;Outpatients;Paradoxical Embolism;Patent Foramen Ovale;Pathogenesis;Patients;personalized medicine;PET/CT scan;Positioning Attribute;Positron-Emission Tomography;post stroke;pre-clinical;preclinical safety;prevent;Prevention;Procedures;prognostic;recruit;Recurrence;Renal clearance function;Residual state;ROC Curve;Rodent Model;Sensitivity and Specificity;Signal Transduction;Source;Specificity;Standardization;Stroke;Study Subject;Techniques;Testing;Therapeutic;Thrombectomy;Thromboembolism;Thrombolytic Therapy;Thrombosis;Thrombus;Time;Transesophageal Echocardiography;Translating;ultrasound;United States;uptake;vascular bed;Veins;Venous;vertebral artery;X-Ray Computed Tomography

PROJECT_TITLE: PET Imaging of Thrombus

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Tuberculosis (TB) became the leading cause of death due to a single infectious agent globally, exceeding HIV, prior to the COVID-19 pandemic and remains a serious public health problem in the country of Georgia which has high rates of highly drug resistant TB. A shortage of well-trained TB investigators in Georgia and globally remains a barrier to achieving the End TB Strategy goals to eliminate TB by 2035. The goals of this D43 renewal application for the “Emory-Georgia TB Research Training Program (EGTB-RTP)” include: 1) transitioning the EGTB-RTP program leadership, management, and training to Georgian investigators over the next 5 years to ensure sustainability; 2) continuing to build human resource capacity and enhance the research infrastructure for robust TB-related research in Georgia; 3) enhance research capacity and ensure program sustainability by providing leadership, mentorship, and team science training; and 4) focus on TB translational research and training with an emphasis on particular areas of strength and importance along the T1-T4 translational research spectrum (including M/XDR-TB, TB-NCDs, PK/PD training and a focus on implementation science and the ability to translate research findings into public policy).

PI_NAMEs: BLUMBERG, HENRY M (contact);TUKVADZE, NESTANI

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Area;Cause of Death;Centers for Disease Control and Prevention (U.S.);Clinical;Collaborations;Communicable Diseases;Country;COVID-19 pandemic;Diagnostic;Doctor of Philosophy;Drug resistance in tuberculosis;Eastern Europe;Ensure;Funding;Goals;HIV;Human;implementation science;improved;Infectious Agent;Institution;International;Lead;Leadership;Lung Diseases;Mentors;Morbidity - disease rate;mortality;Pharmaceutical Preparations;Productivity;programs;Public Health;Public Policy;Publications;Recording of previous events;Reporting;Research;Research Infrastructure;Research Personnel;Research Training;Science;tool;Training;Training Programs;Translating;Translational Research;Tuberculosis;tuberculosis diagnostics;Universities;Vaccines

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-Z(55)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Networking and Information Technology R&D (NITRD);Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Telehealth

ORG_CITY: BIRMINGHAM

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE There are limited exercise options available for wheelchair users to improve their health. The major goal of this study is to test the efficacy of a live, synchronous exercise program with real-time monitoring of vital sign data to improve cardiometabolic health outcomes in wheelchair users. The movement-to-music-cardio (M2M-C) intervention has the potential to improve the way exercise interventions are delivered to wheelchair users, subsequently leading to an increase in sustainable and scalable solutions to improving health outcomes in this population.

PI_NAMEs: WILROY, JEREME  (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: 2 arm randomized control trial;Address;Adult;African American;Age;Asian;Blood Tests;Body Composition;C-reactive protein;cardiometabolic risk;cardiometabolism;Cardiovascular system;Caucasians;Cholesterol;Clinic;clinical practice;clinical training;Communities;Data;disability;Dose;Dual-Energy X-Ray Absorptiometry;Effect Modifiers (Epidemiology);effectiveness evaluation;efficacy evaluation;efficacy testing;Elements;Equipment;Ethnic Origin;evidence base;Exclusion;Exercise;exercise intensity;exercise intervention;exercise program;exercise training;Fasting;fitness;Foundations;Future;General Population;Geography;Goals;Health;Health Promotion;Heart Rate;Hemoglobin;Heterogeneity;Home;Hypertriglyceridemia;Imagery;implementation evaluation;improved;instrument;Insulin;Intervention;Knowledge;Maintenance;Measures;men;Meta-Analysis;Modality;mode of exercise;Movement;Music;Non obese;Obesity;Outcome;Oxygen Consumption;Participant;Patient Self-Report;Pattern;Persons;Phase;Physical activity;Population;post intervention;Procedures;programs;Quality of life;real time monitoring;recruit;Research;respiratory;response;Risk Factors;Risk Reduction;Sample Size;Scanning;sedentary lifestyle;sex;Site;Specific qualifier value;Statistical Models;Structure;Subgroup;synchronous delivery;System;telehealth;Testing;Training;treatment effect;Triglycerides;Underrepresented Populations;Videoconferencing;virtual;Wheelchair user;Wheelchairs;Woman

PROJECT_TITLE: Examining the effects of live telehealth exercise training on cardiometabolic outcomes in wheelchair users


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Although new variants may contribute to surges, we expect population-level immunity to drive the transition of SARS-CoV-2 to an endemic phase where the virus continues to circulate but at lower levels. We propose to identify the immunological features that contribute to this transition in an urban slum community in Brazil which experienced high SARS-CoV-2 infection rates (75%) early in the pandemic and received COVID-19 vaccination later in the pandemic. By identifying the immune drivers for the transition of SARS-CoV-2 endemicity, we will generate key evidence to inform the development of novel vaccines (intranasal, multi- antigen) and new approaches to tracking SARS-CoV-2 infections in populations.

PI_NAMEs: COSTA, FEDERICO ;CUMMINGS, DEREK A;KO, ALBERT ICKSANG (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Address;Affect;analytical method;Antibodies;Antibody Response;Antibody titer measurement;Antigens;Attenuated;Bayesian Analysis;biobank;Biological Assay;Brazil;case finding;Cellular Immunity;cohort;Cohort Analysis;Collaborations;Communities;COVID-19 vaccination;Data;Development;Dimensions;Enzyme-Linked Immunosorbent Assay;Epidemic;Epidemiologic Methods;Epidemiology;evidence base;experience;flexibility;follow-up;Foundations;Future;Health;Histocompatibility Antigens Class II;Humoral Immunities;Hybrids;Immune;Immune response;Immunity;Immunize;immunological status;Immunologics;Individual;Infection;Infection prevention;infection rate;infection risk;insight;Investments;Literature;low and middle-income countries;Maps;Mass Vaccinations;Measurement;Measures;mortality;Mucous Membrane;Nested Case-Control Study;neutralizing antibody;novel;novel strategies;novel vaccines;Outcome;Output;pandemic disease;Participant;pathogen;Phase;Play;Policies;Population;Preparation;Prospective cohort;Public Health;Recording of previous events;Research Design;response;Risk;Risk Reduction;Role;SARS coronavirus;SARS-CoV-2 antibody;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 P.1;SARS-CoV-2 variant;Serology;Serum;Severities;Shapes;Slow-Wave Sleep;Slum;Surveys;Symptoms;Time;tool;transmission process;Vaccination;vaccination strategy;Vaccines;Variant;viral transmission;Virus;Work

PROJECT_TITLE: Immunological drivers of the transition from epidemicity to endemicity of SARS-CoV-2 in a high transmission LMIC setting

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative COVID-19 represents an unprecedented, multisystem shock to children’s educational and family environments, borne disproportionately by children from low-income families, those who are Latinx and Black, and children with special needs. Yet, little existing or emerging research is focusing on these subgroups of children, nor is the extant knowledge base able to identify pre-pandemic dimensions of child functioning or specific features of children’s family, school, and peer contexts, including culturally-embedded protective features, that can serve as effective targets for pandemic relief and recovery efforts aimed at restoring strong developmental growth as children recover from educational and family disruptions during school closures, and continued family disruptions after schools reopened. This application provides a unique opportunity to address these shortcomings by leveraging an existing longitudinal study of exclusively low-income children, with large subgroups of Latinx (including Spanish-speaking ELLs) and Black children, and children with special needs, first observed as preschoolers years prior to the pandemic and who will enter pre-adolescence as COVID-19 continues, to examine the moderating role of (1) children’s pre-existing strengths and vulnerabilities and (2) post-school-reopening family, school, and peer contexts as they explain effects of pandemic-induced educational and family disruption during the period of school closures, and continued family disruption following school reopening, on children’s immediate and longer-term recovery of cognitive/academic and self- regulatory skills, social functioning, and emotional/mental health.

PI_NAMEs: JOHNSON, ANNA D. (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: Address;Adolescence;Adolescent;Affect;Black race;Buffers;Child;Child Development;children of color;Cognitive;cognitive recovery;Complex;COVID-19;COVID-19 impact;COVID-19 pandemic;current pandemic;Data;design;Development;Dimensions;Disasters;early adolescence;Education;Educational Measurement;Emotional;emotional distress;Environment;Event;evidence base;Exclusion;experience;Family;Family Process;fifth grade;first grade;Future;future pandemic;Goals;Growth;Home;improved;Individual Differences;Knowledge;knowledge base;Latinx;Learning;Longitudinal Studies;Low income;lower income families;marginalized population;Measurement;Measures;Mental Health;ninth grade;Nursery Schools;Outcome;pandemic disease;pandemic disruption;pandemic impact;peer;Personal Satisfaction;Population;pre-pandemic;preadolescence;Predisposition;Preparation;Process;protective factors;Public Health;public health emergency;Quarantine;Race;racial minority;Recovery;Research;Research Personnel;resilience;response;restoration;Risk;Role;Sampling;school closure;school reopening;Schools;second grade;Shock;skills;social;Social Functioning;Social isolation;Spanish;Special needs;Specific qualifier value;Students;Subgroup;System;third grade;Youth

PROJECT_TITLE: Succumbing, Surviving, and Thriving: The Development of Low-Income Students in the Long Shadow of COVID-19

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Patient Safety

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative In 2017, approximately 1.68 million individuals in the United States will be diagnosed with cancer and almost 601,000 people will die of the disease. Clearly, new approaches to cancer prevention, diagnosis, and treatment are needed and these will only come from new insights achieved through research. As one of the leading cancer research centers in the country, the Fred Hutchinson Cancer Research Center can help provide leadership for, and participation in our nation’s clinical trials network.

PI_NAMEs: YU, EVAN  (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Achievement;Adult;Alaska;American College of Radiology Imaging Network;base;Cancer Center;cancer prevention;cancer therapy;Clinical;clinical imaging;Clinical Research;Clinical Treatment;Clinical Trials;Clinical Trials Network;Conduct Clinical Trials;Country;Development;Diagnosis;Disease;Fred Hutchinson Cancer Research Center;Goals;Idaho;Imaging Techniques;Individual;Infrastructure;innovation;insight;Institution;Investigation;Lead;Leadership;Malignant Neoplasms;member;Montana;National Cancer Institute;National Clinical Trials Network;NCI Center for Cancer Research;next generation;novel strategies;Patients;Persons;Phase;phase III trial;pre-clinical research;programs;Randomized;rare cancer;Research;research study;Role;Shapes;Site;Southwest Oncology Group;Special Population;treatment trial;United States;Washington;Work;Wyoming

PROJECT_TITLE: Hutchinson Center as Lead Academic Participating Site (UG1)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Wound Healing and Care

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This proposal is a renewal for the UCSF Diabetic Foot Clinical Research Unit, one of the original centers within the NIDDK Diabetic Foot Consortium. In the next funding cycle, our multi-disciplinary team will continue to recruit subjects from our two academic hospitals (UCSF Medical Center and ZSFGH) into the DFC trials, operationalize a new master protocol to enable the study of all patients with active diabetic foot ulcers (DFU), expand our infrastructure through an existing partnership with affiliated Bay Area podiatry clinics, and initiate the study of social determinants of health (SDOH) within the DFC. This research directly addresses a major public health burden in the Bay Area, nation, and global community.

PI_NAMEs: CONTE, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Address;Affect;American;Amputation;Ancillary Study;Area;biobank;Biological Markers;biomarker development;biomarker validation;c-myc Genes;candidate marker;Caring;CCR;Clinic;Clinical;clinical care;clinical center;Clinical Research;Collection;Communities;Data;Data Collection;Diabetes Mellitus;Diabetic Foot;Diabetic Foot Ulcer;Education;Enrollment;experience;Feasibility Studies;Funding;General Hospitals;Goals;health data;health equity;Healthcare Systems;Hospitals;Impaired healing;improved;Individual;Infrastructure;Interdisciplinary Study;Link;Lower Extremity;Medical center;Minority Groups;Morbidity - disease rate;mortality;Multicenter Studies;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Observational Study;Outcome;Parents;Patient-Focused Outcomes;Patients;performance site;Persons;Podiatry;Population;Population Heterogeneity;Prevalence;Protocols documentation;Provider;Public Health;Quality of life;recruit;Recurrence;Research;Research Personnel;Risk Factors;San Francisco;Site;social health determinants;socioeconomics;Specimen;standard of care;Technology;United States;Vascular Diseases;wound care


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Infectious Diseases

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: UNIVERSIDAD PERUANA CAYETANO HEREDIA

PHR: Implementation Research in Infectious Diseases in Peru – GARCIA, Hector H. Training in Infectious Diseases in Peru –  Time for Implementation Research NARRATIVE  This renewal application builds on a long-term Fogarty-supported training program that has trained hundreds of young Peruvian scientists in infectious disease research. While the program maintains its basic foundations including continuous hands-on participation in ongoing research studies and a step wise system involving a Diploma course in Research Methods, a Master’s degree in Epidemiology or related fields, advanced courses overseas, and PhD studies, over the next five-year period we will focus on guiding a new generation of trainees into objective-driven implementation research aimed to improve policies and practices in our region. We have succeeded in forming independent researchers through this training program, many of whom now head their own research labs and have obtained competitive grant funding. Focusing on implementation science should guide new trainees to help translate the research capacity built over the years into pragmatic, evidence-based solutions to public health problems in the region and elsewhere. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: GARCIA, HECTOR HUGO (contact);GILMAN, ROBERT H;GIMBEL, SARAH ODELL

PROJECT_TERMS: 2019-nCoV;Address;Clinical;clinical center;Clinical Research;Clinical Trials;Communicable Diseases;Development;Doctor of Philosophy;doctoral student;Educational Curriculum;Educational workshop;Enrollment;Epidemiology;experience;Exposure to;Foundations;Funding;Generations;graduate student;Grant;Head;health inequalities;Health system;implementation research;implementation science;improved;Master of Science;Mentors;Mentorship;online course;online version;Pathway interactions;Peru;Policies;Process;Productivity;programs;Publications;Research;Research Methodology;Research Personnel;Research Project Summaries;Research Proposals;Research Training;skills;Students;Supervision;System;Time;tool;Training;Translations;Universities;Washington

PROJECT_TITLE: Training in Infectious Diseases in Peru - Time for Implementation Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Z(55)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infant Mortality;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rare Diseases;Sleep Research;Social Determinants of Health;Sudden Infant Death Syndrome

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This work will result in having an elegant health information technology package for infant safe sleep – Infant Sleep Assessment and Best Practice Advisory – along with a training module for enhancing pediatricians’’ counseling skills. If found to be effective the HIT tools can be widely disseminated as it uses the Epic platform, an electronic medical record system used by a majority of US health care facilities. Together this program offers a feasible and potentially effective way to maximize the utility of pediatric well baby visits to promote safe infant sleep.

PI_NAMEs: MCDONALD, EILEEN M (contact);SOLOMON, BARRY S

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Academy;Accidents;African American;African American population;Algorithms;American;Asphyxia;Back;Back to Sleep;Baltimore;Beds;behavior change;Belief;Birth;Black race;Caring;Cessation of life;Child;Child health care;Childhood;Cities;Classification;Clinic;Clinical;Clinical Informatics;Communication;Computerized Medical Record;Counseling;Data;Disadvantaged;Disclosure;disparity reduction;Economically Deprived Population;effectiveness evaluation;electronic medical record system;Electronics;Environment;ethnic disparity;experience;Family;Feedback;follow-up;Funding;Health;Health care facility;health disparity;health disparity populations;health information technology;high risk;Home;improved;Infant;Infant Mortality;injury prevention;innovation;Knowledge;Life;motivational enhancement therapy;National Institute on Minority Health and Health Disparities;Newborn Infant;Outcome;Parents;Patients;pediatrician;Pediatrics;Peer Review;Persons;Population;portability;Prevention Measures;Prevention Research;primary care clinic;primary care provider;programs;Provider;Public Health;Publications;racial disparity;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research;response;Risk;satisfaction;Site;skills;Sleep;Smoke;socioeconomic disadvantage;Source;standard of care;Sudden infant death syndrome;Supination;supine sleep;Surveys;technology intervention;Testing;Theory of Change;tool;Training;Training Activity;United States National Institutes of Health;United States Public Health Service;Visit;Well baby checks;Work

PROJECT_TITLE: Health IT to reduce disparities in risks for sleep-related infant deaths

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(56)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: WHITE PLAINS

ORG_NAME: WINIFRED MASTERSON BURKE MED RES INST

PHR: The proposed research is relevant to public health because understanding motor control circuitry is critical for recovery from paralysis resulting from multiple causes – stroke, spinal cord injury, traumatic brain injuries, motor neuron diseases, and cerebral palsy, which together represent a major cost burden, both in terms of health care costs as well as impact on quality of life of affected individuals and their loved ones. Successful and precise regeneration of this critical circuit, however remains an unattained goal in regenerative and translational neuroscience and hence better strategies are needed toward this end. Our proposed research will identify novel molecules that control the development of appropriate motor output circuitry and has direct applicability for (1) better strategies to promote and/or enhance regeneration and plasticity for functional motor recovery in vivo; and (2) directed differentiation of stem cells for disease modeling, and high-throughput drug screening in vitro.

PI_NAMEs: SAHNI, VIBHU VINODCHANDRA (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Adult;Affect;Age;Amyotrophic Lateral Sclerosis;AT Rich Sequence;Axon;Binding Proteins;Birth;Brain Stem;Cells;Cerebral Palsy;conditional knockout;Corticospinal Tracts;cost;Data;Development;directed differentiation;disease model;Embryo;Embryonic Development;experimental study;Foundations;functional plasticity;gain of function;Gene Delivery;Genes;Genetic Transcription;Goals;Health Care Costs;high-throughput drug screening;Human;in utero;In Vitro;in vivo;Individual;Injections;Injury;Investigation;Knock-in;Knock-in Mouse;Knockout Mice;Label;Life;Link;loss of function;loved ones;Mediating;Molecular;Molecular Target;motor control;motor impairment;Motor Neuron Disease;Motor Neurons;Motor output;motor recovery;Movement;Mus;Natural regeneration;Neocortex;Nervous System;neurogenesis;Neurons;neuropeptide Y;novel;Output;overexpression;Paralysed;Pathway interactions;personalized approach;Play;Population;post stroke;postmitotic;postnatal;Process;Public Health;Quality of life;Recovery;Recovery of Function;regenerative;Regulation;repaired;Reporter;Research;Resolution;Role;single cell ATAC-seq;single-cell RNA sequencing;skills;spasticity;Specific qualifier value;Specificity;Spinal;Spinal Cord;Spinal cord injury;stem cell differentiation;Stroke;stroke recovery;Testing;Time;transcription factor;Transcriptional Regulation;transcriptomics;Transgenic Organisms;translational neuroscience;Traumatic Brain Injury;Work

PROJECT_TITLE: Transcriptional Regulation Over Neurogenesis of Cortical Output Neuron Segmental Identity and Diversity

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Narrative: Translational progress for IDH-mutant gliomas is slowed by protracted disease course and lack of biomarkers and remain ultimately uniformly fatal. Tumors produce high levels of the metabolite D-2-hydroxyglutarate (D2-HG) within the local tumor tissue that is also reliably detectable within cerebrospinal fluid. We propose a series of studies in preclinical models and human patients undergoing surgery and monitoring for IDH-mutant glioma, to determine the utility of (D2-HG) as a monitoring biomarker benchmarked against gold-standard imaging and clinical outcomes.

PI_NAMEs: BURNS, TERRY  (contact)

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Acceleration;Benchmarking;Biochemical Genetics;Biological;Biological Assay;Biological Markers;Bioluminescence;biomarker discovery;burden of illness;cancer cell;candidate marker;Cellularity;Cerebrospinal Fluid;Characteristics;Chemotherapy and/or radiation;Clinic;Clinical;Clinical Management;Clinical Trials;cohort;Combined Modality Therapy;Core Facility;Data;Detection;Devices;Diagnosis;Diagnostic;Disease;Disease Progression;Disease Surveillance;epigenomics;Excision;extracellular;follow-up;Glioma;Histologic;Human;Image;Individual;individual patient;individualized medicine;Laboratories;Lesion;Linear Regressions;Location;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Mass Spectrum Analysis;Measurement;Measures;Metabolic;metabolic phenotype;metabolomics;Microdialysis;Minor;Modeling;Molecular;Monitor;Monitoring for Recurrence;Mus;mutant;neurosurgery;new therapeutic target;Newly Diagnosed;Ommaya Reservoir;Operative Surgical Procedures;Outcome;Patients;Performance;Phase;Postoperative Period;Pre-Clinical Model;Production;Progressive Disease;Property;radiation effect;radiological imaging;Recurrence;Recurrent disease;Recurrent tumor;Residual Neoplasm;Resistance;response;Sampling;Sensitivity and Specificity;Series;Site;Spectrum Analysis;Spinal Puncture;Stereoisomer;survival outcome;Testing;Therapeutic;Time;translational progress;translational therapeutics;treatment response;tumor;tumor progression;Tumor Tissue;Tumor Volume;Validation;Ventricular;young adult

PROJECT_TITLE: Intracranial D-2-Hydroxyglutarate as a Monitoring Biomarker for IDH-mutant Glioma.

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


PHR: PROJECT NARRATIVE  Obstructive sleep apnea (OSA) is common across the age spectrum, associated with significant cardiovascular disease, and represents a formidable public health burden in the United States. Currently, we lack understanding of the pathologic effects of incident and developing OSA on cardiovascular function in younger and healthier individuals with OSA, which could lead to improved risk stratification and treatments earlier in the disease course that impact later-life cardiovascular outcomes. Capitalizing on the strengths of an experienced, multi-disciplinary team, we will: 1) leverage our ability to study an important sub-group of young individuals at-risk for OSA and enriched with traditional early cardiovascular risk, which include young male and female collegiate athletes; 2) analyze the association between incident and worsening OSA and pathologic changes in cardiovascular function; and 3) assess the metabolic profile in young individuals with OSA that is associated with early cardiovascular pathophysiology.

PI_NAMEs: KIM, JONATHAN HO-YOUN (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Age;aged;aging population;American;amino acid metabolism;Apnea;arterial stiffness;Athletic;Blood Vessels;Body mass index;Body Weight Changes;Carbohydrates;Cardiac;Cardiology;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;career;Clinical;Clinical Trials;cohort;college;Continuous Positive Airway Pressure;Coupling;Data;Disease;Early treatment;effective therapy;Exercise Physiology;Exhibits;experience;experimental study;Female;Functional disorder;General Population;Goals;Grant;heart imaging;High Prevalence;high risk;High Risk Woman;Hybrids;Hypertension;Image;Impairment;improved;Incidence;indexing;Individual;Injury;innovation;insight;interest;Intervention Studies;Knowledge;late life;Left;Left Ventricular Mass;Link;Lipids;longitudinal analysis;Lysine;male;Manufactured football;Measures;Medicine;Metabolic;metabolic profile;Metabolism;metabolome;metabolomics;Modeling;Morbidity - disease rate;multidisciplinary;Natural experiment;novel;novel marker;observational cohort study;Observational Study;Obstructive Sleep Apnea;Older Population;Outcome;Pathologic;Patients;Phenotype;physiologic model;Physiologic pulse;Physiological;Plasma;Population;Populations at Risk;Preventive therapy;prospective;Public Health;Research Design;Resolution;Risk;risk stratification;Scientist;Series;Sleep;Sports;Students;Subgroup;Testing;Tissues;Training;undergraduate student;United States;Ventricular;Weight;Weight Gain;Work;Workload;young man;Youth

PROJECT_TITLE: Obstructive Sleep Apnea and Associated Pathologic Cardiovascular Phenotypes in Young Individuals: A Comprehensive and Longitudinal Analysis of At-Risk College-Aged Students

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Disparities in colorectal cancer (CRC) surgical outcomes have been known to exist for years, with significant negative consequences for the underrepresented (e.g. Black patients), and society as a whole. Insight from existing literature and our preliminary studies suggest that the most essential remaining disparities in CRC are related to large differences in mortality and morbidity following CRC surgery across hospitals. The goal of this study is to minimize or eliminate disparities in CRC surgery by 1) leveraging cutting edge predictive analytics utilizing both patient and provider characteristics to personalize referral recommendations, 2) simulating the effects of data driven referrals on Societal Welfare for multiple populations, 3) using scenario testing to understand the willingness of referring providers to trade off convenience and reputation for quality of care when making referral recommendations, and 4) generating evidence to guide new policies that support the use of data driven, personalized referrals to minimize disparities.

PI_NAMEs: KELZ, RACHEL  (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Address;adjudication;Adoption;adverse outcome;Affect;American College of Surgeons;Attention;black patient;Black Populations;Black race;cancer care;cancer health disparity;Cancer Patient;cancer surgery;Caring;Cause of Death;Cessation of life;Characteristics;cohort;colon cancer patients;Colorectal Cancer;colorectal cancer treatment;Communities;comparative;Complex;Data;Death Rate;Decision Aid;Decision Making;design;Development;Diagnosis;Disadvantaged;Disease;Disparity;disparity elimination;disparity reduction;Educational Status;Equity;Event;experience;experimental study;Familiarity;Goals;Guidelines;health care delivery;health equity;Home;Hospitals;improved;improved outcome;Incentives;Inferior;insight;interest;Intervention;Knowledge;Linear Models;Literature;Low income;machine learning algorithm;Malignant Neoplasms;Medicare;Methods;Minority;Modeling;Morbidity - disease rate;mortality;multidisciplinary;new technology;novel;older adult;Operative Surgical Procedures;Organ;Outcome;outcome prediction;Participant;Patient risk;Patient-Focused Outcomes;Patients;Pattern;Perception;Performance;personalized predictions;personalized risk prediction;Physicians;Pilot Projects;Policies;Policy Maker;Population;Predictive Analytics;predictive modeling;preference;Process;Provider;Quality of Care;Questionnaires;Race;Recommendation;Research;Resources;response;Risk;risk prediction;risk prediction model;risk stratification;Running;Rural;Sampling;Science;simulation;Societies;Solid;Specific qualifier value;Specificity;standard of care;statistics;Surgeon;surgery outcome;surgical disparities;surgical risk;Survival Rate;Testing;tool;Training;Travel;treatment disparity;Treatment outcome;Uncertainty;United States National Institutes of Health;uptake;Variant;Vulnerable Populations;welfare;willingness;Work

PROJECT_TITLE: Personalized Provider Selection to Reduce Surgical Disparities

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Rare Diseases

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative The International Registry of Werner Syndrome recruits adult progeroid patients from all over the world and serves as a resource for colleagues who do basic research on the biology of aging. We propose to extend our efforts to identify novel genes responsible for newly discovered progeroid syndromes using next generation sequencing. We will also aggressively pursue our efforts to discover and investigate potential therapeutic approaches for the treatment of progeroid syndromes.

PI_NAMEs: OSHIMA, JUNKO  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Abbreviations;Adult;Affect;age acceleration;age related;age-related disease;Aging;Autophagocytosis;Basic Science;Biocompatible Materials;Biological;biological research;Biology of Aging;Blood specimen;BSCL2 gene;carcinogenesis;Categories;causal variant;Cell Culture Techniques;Cells;Chronic;Clinic;Clinical;clinical application;Clinical Trials;Collaborations;comparative genomic hybridization;comparison control;Cryopreservation;Cultured Cells;cytokine;Development;Dideoxy Chain Termination DNA Sequencing;Disease;disease phenotype;DNA Damage;DNA Polymerase III;DNA-Directed DNA Polymerase;efficacy evaluation;Enrollment;epigenetic clock;established cell line;Exhibits;exome;exome sequencing;experimental study;Family;Family member;FDA approved;Fibroblasts;Follow-Up Studies;gene discovery;Genes;Genetic;genetic analysis;Genetic Diseases;genetic pedigree;genetic variant;genome sciences;genome sequencing;Genome Stability;genome-wide;Genomic Instability;genomic locus;Genotype;Geroscientist;Goals;hallmarks of aging;helicase;high throughput screening;Human;Inflammation;inhibitor;International;Janus kinase;Japan;Japanese;kinase inhibitor;Libraries;Lipids;Longevity;MADH4 gene;Maintenance;Malignant Neoplasms;Manuscripts;MDM2 gene;Mediating;member;Metformin;Microsatellite Instability;Mitochondria;mTOR Inhibitor;mutant;Mutation;new therapeutic target;next generation sequencing;nicotinamide-beta-riboside;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;Nuclear Structure;Nucleotide Excision Repair;Oxidative Stress;Parents;participant enrollment;Pathogenesis;Pathogenicity;Pathway interactions;Patients;peripheral blood;Pharmaceutical Preparations;Phenotype;Plasma;Play;Polymerase;preclinical study;Process;Production;Qualifying;Rare Diseases;Reagent;recruit;Registries;Regulation;Research;Resources;Role;screening;senescence;senescence associated secretory phenotype;Series;Siblings;Signal Transduction;Sirolimus;Small Interfering RNA;Specimen;STAT protein;Syndrome;synergism;telomere;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Tissue Sample;TP53 gene;transcriptome sequencing;Transforming Growth Factor beta;Translation Initiation;Translational Research;Variant;Washington;Werner Syndrome;whole genome;WRN gene

PROJECT_TITLE: International Registry for Werner Syndrome

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE This project seeks to systematically examine the relationship between chronic inflammation and type 2 diabetes (T2D) by incorporating multi-omics data from several large prospective cohort studies. The proposed research will yield novel evidence on the biological mechanisms underlying the relationship between chronic inflammation and T2D risk. Novel pathways, and specific genes, proteins, and metabolites identified in this research will serve as the critical first steps for future development of biomarkers and therapeutic targets for T2D prevention and treatment.

PI_NAMEs: LI, JUN  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: adiponectin;Adult;Affect;Applications Grants;Area;biobank;Bioinformatics;Biological;biomarker development;C-reactive protein;Cardiometabolic Disease;Cardiovascular Diseases;career;case control;Chronic;Clinical;cohort;Complex;cytokine;Data;Data Analytics;Development;Diabetes Mellitus;Diabetes prevention;diabetes risk;Diet;dietary;Dietary Assessment;Dimensions;Disease;disorder prevention;Early Diagnosis;Environmental Risk Factor;Epidemiologist;Epidemiology;Etiology;Follow-Up Studies;Food;Future;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;genomic data;genomic locus;Genomics;Genotype-Tissue Expression Project;Goals;Health Professional;high dimensionality;Hispanic Community Health Study/Study of Latinos;IL6 gene;improved;indexing;Inflammation;Inflammatory;inflammatory marker;innovation;Intake;Interleukin-6;Kidney Diseases;Knowledge;machine learning model;Mediating;Mentors;Metabolic;metabolome;metabolomics;Methodology;Methods;mortality;multidimensional data;Multiomic Data;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;Nested Case-Control Study;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;Nurses' Health Study;Nutritional;Pathogenicity;Pathway interactions;Patient Self-Report;Pattern;Phenotype;Physiological;Pilot Projects;Plasma;Positioning Attribute;Predisposition;Prevention;prospective;Prospective, cohort study;Proteins;Proteome;Proteomics;Public Health;Qi;Regulatory Element;Research;Research Design;Research Personnel;Resources;response;Retinal Diseases;Risk;Risk Factors;Role;skills;System;systemic inflammatory response;Systems Biology;Technology;therapeutic target;TNFRSF1A gene;Training;training opportunity;transcriptome;transcriptomics;White Blood Cell Count procedure;whole genome;Work

PROJECT_TITLE: Chronic Inflammation and Type 2 Diabetes: A Multi-omics Approach

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Public health relevance: The orally active elafin-Eudragit formulation is effective, convenient, and safe for reversal of preexisting intestinal stricture. We propose to understand the therapeutic performance of elafin in animal models. If the results are positive, elafin may be a new therapeutic agent against colitis-associated intestinal fibrosis in the future.

PI_NAMEs: KOON, HON WAI  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Affect;Agonist;Animal Model;Anti-Inflammatory Agents;anti-microbial peptide;Antibiotics;Cathepsins;clinical application;Clinical Trials;Colitis;Collagen;Colon;Crohn's disease;Data;Development;Diabetes Mellitus;diagnostic biomarker;efficacy evaluation;Environment;Eudragit;Excision;exosome;Fibroblasts;Fibrosis;Formulation;Future;Genes;High Fat Diet;Human;ileum;in vivo;inhibitor;Intestinal Fibrosis;Intestines;Lentivirus;Link;Literature;Mediating;Methods;Methylcellulose;Modeling;mouse model;multidisciplinary;Mus;novel therapeutic intervention;novel therapeutics;Obesity;Operative Surgical Procedures;Oral;Oral Administration;overexpression;Pathway interactions;Patients;Peptide Hydrolases;Performance;PI3 gene;prevent;Protease Inhibitor;protective effect;Proteinase-Activated Receptors;public health relevance;Publishing;Quality of life;Receptor Signaling;Regimen;Reporting;Risk;Role;Salmonella;Serum;Therapeutic;Therapeutic Agents;therapeutic evaluation;Tissues;transcriptome;transcriptome sequencing

PROJECT_TITLE: Oral elafin formulation for intestinal fibrosis

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Clinical Research;Nutrition;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention

PHR: Project Narrative  Osteoporosis and fractures are a major public health burden and a growing body of research suggests that acidosis, even when subclinical, can have detrimental effects on bone metabolism and health. This proposal’s goal is to prospectively study the association between acid-base status and risk of fractures. We expect these studies to produce novel insights into the development of fractures that may lead to new approaches to their prevention and treatment.

PI_NAMEs: PAIK, JULIE  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Acidosis;Acids;Adult;Affect;Age;Aging;Alkalies;Amino Acids;Anions;Archives;Attention;Automobile Driving;base;Bicarbonates;Biological Assay;biological specimen archives;Biostatistical Methods;bone;Bone Density;bone health;bone metabolism;Bone remodeling;bone repair;Bone Resorption;Buffers;case control;Cell Physiology;Citrates;Clinical;clinically significant;cohort;Cohort Studies;Computing Methodologies;cost;Cross-Sectional Studies;Cysteine;Data;Data Analyses;Development;Diagnosis;Diet;dietary;disability;Epidemic;Equilibrium;Excretory function;extracellular;follow-up;Follow-Up Studies;Fracture;fracture risk;Gas Chromatography;Generations;Glutamine;Goals;Health Professional;Hip Fractures;Impairment;Incidence;insight;Investigation;Kidney;lifestyle data;lifetime risk;Liquid Chromatography;liquid chromatography mass spectrometry;Liver;Longitudinal Studies;Malates;Mass Spectrum Analysis;Measures;men;Metabolic acidosis;metabolomics;Methionine;Morbidity - disease rate;mortality;multidimensional data;Nested Case-Control Study;novel;novel strategies;Nurses' Health Study;Osteoblasts;Osteogenesis;Osteoporosis;Plasma;Population Study;Potassium;Prevalence;Prevention;Principal Component Analysis;Production;prospective;Prospective Studies;Public Health;repaired;Research;Risk;Risk Factors;Salts;Sampling;secondary analysis;Sex Differences;Site;Skeleton;Spinal Fractures;Statistical Methods;Sulfur;Technology;Testing;Time;tool;Urine;western diet;Woman;wrist fracture

PROJECT_TITLE: Acid-Base Status as a Novel Risk Factor for Fractures

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Digestive Diseases;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Liver Disease;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse;Telehealth

PHR: PROJECT NARRATIVE The advanced stage of chronic liver disease is the 12th most common cause of death in the U.S. Regular disease monitoring and prevention of complications is key to increased patient survival and quality of life, yet the COVID- 19 pandemic has created unprecedented disruption in care for this important patient population. The current study evaluates the effect of changes in care delivery and use of telemedicine on patient outcomes and experience in vulnerable patients with advanced liver disease and its usefulness for alcohol treatment using a stepped-care intervention model. Developing best practices for use of telemedicine for liver disease, alcohol treatment, and other serious chronic conditions in the post-pandemic period is timely and a very high public health priority. 1

PI_NAMEs: KHALILI, MANDANA  (contact);SATRE, DEREK D

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: 2019-nCoV;acute liver disease;addiction;Address;Adherence;Affect;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol misuse;Alcoholic Liver Diseases;Alcohols;Ascites;barrier to care;Biological Models;Cardiovascular Diseases;care delivery;care outcomes;Caring;Cause of Death;Chronic;chronic alcohol ingestion;Chronic Disease;Chronic Kidney Failure;chronic liver disease;Cirrhosis;Clinic;Clinical;Communities;comorbidity;Complex;Computerized Medical Record;Counseling;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 risk;COVID-19 susceptibility;Data;Deterioration;Diabetes Mellitus;Diagnostic Services;Disease;Disease Management;Disease Outcome;disorder prevention;Disparity;Dissemination and Implementation;drinking;effective intervention;efficacy evaluation;Encephalopathies;Ensure;Equity;Esophageal Varix;ethnic minority;Evaluation;experience;Fibrosis;follow-up;Gastrointestinal Hemorrhage;Goals;Health;health care availability;health care delivery;health care service;health disparity;health disparity populations;Health system;Healthcare Systems;Hepatology;High Prevalence;high risk;improved;Individual;infection risk;innovation;Intervention;Laboratories;Liver;Liver Cirrhosis;Liver diseases;liver function;liver transplantation;Medical;medical specialties;Mental disorders;Modeling;Monitor;Morbidity - disease rate;mortality;motivational enhancement therapy;Natural experiment;novel;Outcome;pandemic disease;pandemic impact;pandemic response;Patient Care;patient population;Patient-Focused Outcomes;Patients;Persons;Physicians;Police;Population;post-pandemic;Predisposition;Prevalence;prevent;Prevention;Preventive measure;Primary carcinoma of the liver cells;Primary Care;Process;prospective;Psychological Impact;public health priorities;Quality Indicator;Quality of Care;Quality of life;racial minority;Randomized, Controlled Trials;Recovery;reduced alcohol use;Reporting;response;Risk;Risk Factors;safety net;Sampling;SARS-CoV-2 infection;satisfaction;screening;screening services;Service delivery model;Services;Site;Social isolation;socioeconomic disadvantage;Substance Use Disorder;Surveys;System;telehealthcare;Telemedicine;Testing;Time;treatment as usual;United States;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Vulnerable Populations

PROJECT_TITLE: Impact of the COVID-19 pandemic on patient outcomes, telehealth care delivery, and treatment for unhealthy alcohol use in vulnerable patients with advanced liver disease across two healthcare systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(56)R]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Rural Health;Social Determinants of Health

ORG_CITY: BAKERSFIELD

ORG_NAME: CALIFORNIA STATE UNIVERSITY BAKERSFIELD AUXILIARY FOR SPONSORED PROGRAMS ADMINISTRATION

PHR: Project Narrative The nation's preeminence in the biomedical and behavioral sciences cannot be maintained without tapping into every available source of talent and perspective. The fact that certain ethnic and racial groups are underrepresented in the biomedical and behavioral sciences shows that we, as a nation, should do better to provide the tools necessary to all students that want to become scientists. The U-RISE program at California State University, Bakersfield, provides aspiring young researchers from diverse backgrounds transformational experiences that will strengthen their acceptance and successful completion of Ph.D.’s in the biomedical, behavioral and clinical fields.

PI_NAMEs: GANCARZ-KAUSCH, AMY ;SUMAYA, ISABEL  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Admission activity;Agriculture;Area;Bachelor's Degree;Behavioral Research;Behavioral Sciences;Biochemistry;Biology;Biomedical Research;California;Chemistry;community engagement;Critical Thinking;Dedications;Doctor of Philosophy;Doctor's Degree;Ethnic Population;experience;Faculty;Global Awareness;graduate school;Graduation Rates;Intramural Research;Kinesiology;knowledge base;Leadership;Learning;life-long learning;Location;Measures;Minority Groups;Mission;Outcome;peer coaching;Personal Growth;Poverty;programs;Psychology;racial population;Research;Research Personnel;Rural;Scholarship;Scientist;Series;service learning;Services;skills;Source;Students;success;Talents;Testing;Time;tool;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities

PROJECT_TITLE: U-Rise at California State University Bakersfield

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative:  Neuron migration is a crucial process during nervous system development controlled by a myriad of signaling pathways and signaling pathway regulators. The proposed studies will uncover the role of CRL5 in regulating phosphoinositide metabolism and Ca2+ dynamics to control projection neuron migration and localization in the neocortex.

PI_NAMEs: DICKSON, EAMONN JAMES;SIMO, SERGI  (contact)

PROJECT_TERMS: Address;Affect;Area;autism spectrum disorder;Biochemical;Biology;Brain;brain morphology;Calcium;Cell membrane;Cell Polarity;Central Nervous System;Cognition;Complex;conditional knockout;Core Protein;Cullin 5 Protein;Data;Development;Down-Regulation;Embryonic Development;Ensure;Epilepsy;Etiology;Event;excitatory neuron;experimental study;Frequencies;Goals;Health;hippocampal pyramidal neuron;Human;Image;inhibitory neuron;Intellectual functioning disability;Interneurons;Knockout Mice;Knowledge;Language;lateral ventricle;Lipids;lissencephaly;loss of function;malformation;Metabolism;migration;Modeling;Molecular;Monomeric GTP-Binding Proteins;Morphogenesis;Multiprotein Complexes;mutant;Neocortex;nerve stem cell;Nervous System;nervous system development;neural circuit;Neuroanatomy;neuronal excitability;Neuronal Migration Disorder;Neurons;neuropsychiatric disorder;novel;Pathway interactions;Phenotype;phosphatidylinositol 3,4,5-triphosphate;Phosphatidylinositol 4,5-Diphosphate;phosphatidylinositol 4-phosphate;Phosphatidylinositols;Phosphotransferases;Positioning Attribute;postmitotic;Process;Proteins;recruit;Regulation;Reporting;response;Role;Schizophrenia;Series;Signal Pathway;Signal Transduction;Stereotyping;Stimulus;Structure;superresolution microscopy;Surface;Synapses;targeted treatment;Telencephalon;Testing;Therapeutic Intervention;ubiquitin-protein ligase;voltage

PROJECT_TITLE: Regulation of phosphoinositide metabolism and calcium dynamics in the neocortex


NIH_SPENDING_CATS: Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: Characterizing the Function of the Periplasmic Protease Tsp in Chlamydial Secondary Differentiation Chlamydiae are important pathogens of humans and significant causes of morbidity, causing a range of illnesses including sexually transmitted diseases, trachoma, pneumonia, and other respiratory tract infections. The burden of these infections stems from their lack of symptoms, which can lead to chronic conditions such as infertility, adult-onset asthma, and, in some cases, possibly exacerbating heart disease. The work proposed here is to define the role of conserved and novel elements associated with periplasmic protein degradation in chlamydiae, which in turn may lead to the design of novel therapeutics that would eliminate the broad effects of standard antimicrobial therapy on normal flora.

PI_NAMEs: FISHER, DEREK JAMES;OUELLETTE, SCOT P (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Adult;antimicrobial;Asthma;Bacteria;Biochemical;Biology;Blindness;C-terminal processing peptidase;candidate validation;Cell division;Cell Physiology;Cell Wall;Cells;Centers for Disease Control and Prevention (U.S.);Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Chronic;CRISPR interference;crosslink;Data;Dependence;design;Developed Countries;Developing Countries;Development;Disease;Elements;Ensure;Enzymes;Escherichia coli;Genes;Genetic;Genetic Techniques;Genetic Transcription;Genome;Goals;Gram-Negative Bacteria;Growth;Growth and Development function;Healthcare Systems;Heart Diseases;Homeostasis;Human;human pathogen;In Vitro;in vivo;Incidence;infection burden;Infertility;knock-down;Link;Lipids;Lipoproteins;Membrane;Metabolic;Modification;Morbidity - disease rate;Morphology;normal microbiota;novel;novel therapeutics;Organism;overexpression;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Patients;Pelvic Inflammatory Disease;Penicillin-Binding Proteins;Peptide Hydrolases;Peptidoglycan;periplasm;Periplasmic Proteins;Phase;Pneumonia;prevent;Process;protein degradation;Proteins;Proteomics;Reiter Disease;Relaxation;Reporting;Respiratory Tract Infections;Role;Sexually Transmitted Diseases;stem;Stress;Symptoms;System;Therapeutic;Therapeutic Agents;therapeutic target;Time;tool;Trachoma;tubal infertility;Work

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: Portland

ORG_NAME: PDX PHARMACEUTICALS, INC.

ORG_STATE: OR

PHR: Project Narrative Lung cancer is by far the leading cause of cancer death, accounting for 1 out of 4 cancer deaths among both  men and women. Developing effective therapies to improve lung cancer treatment and patient quality of life is  an urgent need. We propose to co-deliver a potent anti-cancer drug, an immune checkpoint inhibitor, and an  immune-stimulating agent on our well-designed nanoparticle platform to produce a novel single  immunotherapy that is curative for advanced lung cancer.

PI_NAMEs: NGAMCHERDTRAKUL, WORAPOL  (contact);YANTASEE, WASSANA

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: Accounting;adaptive immune response;analytical method;anti-cancer;anti-PD-L1 antibodies;anti-PD1 antibodies;Antigen Presentation;Antigens;Antineoplastic Agents;Benchmarking;Bilateral;Binding;Biodistribution;Biological Markers;Body Weight;Buffers;cancer cell;Cancer cell line;Cancer Etiology;Cancer Patient;cancer survival;cancer therapy;candidate selection;CD8-Positive T-Lymphocytes;Cell Death;Cells;Cessation of life;Clinical Trials;clinically relevant;cytotoxic;Data;density;design;Dose;Dose Limiting;Drug Combinations;Drug Kinetics;effective therapy;efficacy evaluation;Feedback;Flow Cytometry;Growth;Health;Hematology;Heterogeneity;Histology;Human;humanized mouse;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune Evasion;immune stimulant;immune stimulatory agent;Immunocompetent;Immunohistochemistry;Immunologic Stimulation;immunoregulation;Immunotherapy;improved;in vivo;Infusion procedures;inhibitor;Intravenous;kinase inhibitor;Lead;lead candidate;Legal patent;liver function;Lung;lung cancer cell;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;men;Minority;Mitotic;Modeling;Monitor;Monkeys;mouse model;Mus;nano;Nanoimmunotherapy;nanoparticle;nanoparticle delivery;nanoparticle drug;Non-Small-Cell Lung Carcinoma;nonhuman primate;Normal Cell;novel;novel therapeutics;Oligonucleotides;Outcome;outcome prediction;particle;Particle Size;patient derived xenograft model;Patients;PD-1/PD-L1;Pharmaceutical Preparations;Pharmacotherapy;Phase;PLK1 gene;polo-like kinase kinase 1;Positioning Attribute;programmed cell death ligand 1;Proteins;Quality of life;Radiation therapy;Regimen;Renal function;Resistance;Safety;safety study;Saline;Scheme;Small Business Innovation Research Grant;Specificity;STAT3 gene;success;Surface;Survival Rate;T-Lymphocyte;targeted delivery;targeted treatment;Technology;Testing;Therapeutic Agents;Toxic effect;treatment effect;Treatment Protocols;tumor;Tumor Escape;tumor growth;Tumor Immunity;tumor microenvironment;uptake;Woman

PROJECT_TITLE: Novel Nano-immunotherapy for Treatment of Non-small Cell Lung Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-L(12)B]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Tumor-associated macrophages (TAMs) adopt an M2-like phenotype that supports angiogenesis, attenuates anti-cancer immune responses, and facilitates metastatic dissemination. Although studies in humans and experimental animal models support targeting TAMs for anti-cancer therapy, the environmental conditions and molecular mechanisms that promote their M2-like phenotype are poorly understood. The overall goal of this application is to delineate the contribution of a novel metabolite-driven epigenetic mechanism to the M2-like phenotype of TAMs as well as their impact on tumor growth and adaptive immunity.

PI_NAMEs: BECKER, LEV  (contact);ZHAO, YINGMING

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: adaptive immunity;Adopted;angiogenesis;Animals;anti-cancer;anti-cancer therapeutic;Antibodies;Attenuated;Bacteria;Biochemical;Biochemical Process;Bone Marrow;cancer therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;cytokine;Development;effector T cell;EP300 gene;Epigenetic Process;Experimental Animal Model;experimental study;Gene Expression;gene function;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Glycolysis;Goals;Heterogeneity;Histones;Human;Hypoxia;IL4 gene;Immune;Immune response;improved;In Vitro;in vivo;Inflammatory;insight;Interleukin-13;Knowledge;lactate dehydrogenase A;Lysine;Macrophage;Malignant Neoplasms;Mediating;Metabolic;Mitochondria;Modeling;Modification;Molecular;Molecular Target;monocyte;Mus;Myeloid Cells;Nature;Neoplasm Metastasis;novel;Pathway interactions;Patients;Phase;Phenotype;Prevalence;Process;Production;Prognosis;promoter;Proteins;Proteomics;Publishing;Respiration;Role;Stimulus;T-Cell Depletion;Testing;Therapeutic;therapeutic target;transcriptomics;Translations;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;tumorigenesis;Work

PROJECT_TITLE: Lactate production by tumor associated macrophages promotes tumorigenesis

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Patient Safety;Rare Diseases

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: Narrative Dartmouth-Hitchcock Health is the leading specialty care network for a vast geographic region covering New Hampshire and Vermont statewide. The Norris Cotton Cancer Center (NCCC) is the academic hub for services for rare and advanced cancer cases across the region. As a Lead Academic Participating Site in the National Cancer Institute’s National Clinical Trials Network, our overarching mission is to advance the NCTN collaborative clinical research program of definitive clinical trials, including multi-modality, umbrella/basket, and rare tumor trials, and to translate basic science studies into meaningful advancements in the care of Northern New England cancer patients.

PI_NAMEs: DRAGNEV, KONSTANTIN H. (contact)

PROJECT_TERMS: Address;Adolescent and Young Adult;Adult;Advanced Malignant Neoplasm;American College of Radiology Imaging Network;anti-cancer research;Back;Basic Science;Cancer and Leukemia Group B;cancer care;Cancer Center;cancer clinical trial;cancer genomics;cancer imaging;Cancer Patient;cancer therapy;cancer type;Caring;Catchment Area;Clinical;clinical application;Clinical Cancer Center;Clinical Oncology;Clinical Research;clinical translation;Clinical Treatment;Clinical Trials;Clinical Trials Cooperative Group;Collaborations;college;Combined Modality Therapy;community based practice;Comprehensive Cancer Center;Conduct Clinical Trials;Consent;design;Development;Diagnosis;Diagnostic;Disease;Eastern Cooperative Oncology Group;Education;Eligibility Determination;Engineering;Enrollment;Evaluation;Faculty;Funding;Funding Opportunities;Future;Geographic Locations;Geography;Goals;Health;Health system;Image;Immunologics;Immunology;Immunotherapeutic agent;Industry;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Intervention;Knowledge;Laboratories;Lead;Leadership;Lebanon;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical center;medical schools;medical specialties;member;Mission;Modality;Molecular;Molecular Target;Monitor;Multi-Institutional Clinical Trial;multidisciplinary;multimodality;National Cancer Institute;National Clinical Trials Network;NCI Center for Cancer Research;New England;New Hampshire;Norris Cotton Cancer Center;novel;Nursing Research;Oncology;Oncology Group;operation;Operative Surgical Procedures;Patient Care;patient population;Patient Selection;Patients;Performance;Phase;phase III trial;Positioning Attribute;prevent;Preventive;Principal Investigator;Process;programs;Protocols documentation;Radiation therapy;Randomized;rare cancer;Recording of previous events;Reporting;Request for Applications;Research;Research Personnel;Resource Sharing;response;Rural;Schools;Science;Scientist;screening;Services;Site;Special Population;symposium;System;Target Populations;targeted treatment;Testing;Therapeutic;Translating;Translational Research;treatment trial;tumor;Underserved Population;Vermont

PROJECT_TITLE: NCI National Clinical Trials Network - Network Lead Academic Participating Sites (UG1)


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Our personal and work relationships are frequently characterized by changing dynamics and insufficient information to precisely calculate our actions’ probability of success. The proposed studies investigate whether difficulties making decisions under these forms of uncertainty are common to both anxiety and depression and potentially also to other forms of psychopathology. Better understanding these difficulties will facilitate development of new psychoeducational and cognitive interventions targeted at remediating difficulties in decision-making under these forms of uncertainty and hopefully aid in better identifying patient groups that might benefit from such interventions.

PI_NAMEs: BISHOP, SONIA JANE (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TITLE: Elucidating the relationship between decision-making under second-order uncertainty and dimensions of negative affect using computational modeling

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Properly studying a single organ like the skin now requires a multidisciplinary approach that considers not only epithelial cells but also immune cells and even the nervous system. Thus, future trainees will require training in interdisciplinary science using a systems approach to marry different fields like neuroscience and immunology into one (e.g., neuroimmunology). This Training Program in Systems Skin Biology aims to build on the existing institutional strengths of Icahn School of Medicine at Mount Sinai (ISMMS) to create an intersectional science training program for both predocs and postdocs in Systems Skin biology.

PI_NAMEs: KIM, BRIAN  (contact);MILLAR, SARAH E.

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Biology;Research Training;Skin;System

PROJECT_TITLE: Research Training in Systems Skin Biology


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Social communication depends on the integration of sensory, emotional and cognitive information by a large network of brain regions, which includes the ventrolateral prefrontal cortex (VLPFC). In this proposal we will examine how face and vocal information are integrated in prefrontal neurons, what elements of faces and vocalizations are integrated and whether integration occurs in the same manner across different prefrontal regions. Elucidating how prefrontal cortex integrates face and vocal information will help us understand neurological disorders such as autism spectrum disorders, schizophrenia and language impairments where multisensory integration is impaired.

PI_NAMEs: ROMANSKI, LIZABETH M (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Affect;Afferent Neurons;Anatomy;Anterior;Anterolateral;Area;Auditory;auditory stimulus;autism spectrum disorder;Back;Brain region;Cell Physiology;Cells;Cognitive;cognitive process;Communication;Communication impairment;Complex;Computing Methodologies;Data;Electrodes;Elements;Emotional;Face;Face Processing;frontal lobe;Gestures;Homologous Gene;Human;Impairment;Inferior;insight;Intellectual functioning disability;Investigation;Laboratories;Language;Language Development;language impairment;Lateral;Macaca;member;Modality;Modeling;Motor;movie;multi-electrode arrays;multisensory;nerve supply;Nervous System Disorder;neural;neuromechanism;Neurons;nonhuman primate;novel;Pattern;Perception;Play;Population;preference;Prefrontal Cortex;Primates;Process;Research;response;Role;Schizophrenia;semantic processing;Sensory;sensory integration;sensory stimulus;Short-Term Memory;social communication;Speech;speech processing;Stimulus;System;Temporal Lobe;Time;Visual;visual information;vocalization

PROJECT_TITLE: Audiovisual Integration in the Prefrontal Cortex

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The continuous proliferation of cancer cells demands profound translational and metabolic reprograming. Nevertheless, we still lack a clear picture of the unique adaptations that facilitate aberrant biomass accumulation specifically in cancer cells. This proposal seeks to understand the role of the transcription factor aryl hydrocarbon receptor (AHR) and its ligand kynurenine in protein synthesis and proliferation of colon cancer cells.

PI_NAMEs: CONACCI-SORRELL, MARALICE  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Amino Acids;Animals;APC gene;Aryl Hydrocarbon Receptor;Automobile Driving;Binding;Biogenesis;Biomass;cancer cell;Cancer Cell Growth;cancer therapy;cell growth;Cell Nucleus;Cell Proliferation;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;Colon Carcinoma;colon growth;Development;Enzymes;Epithelial Cells;Gene Expression;Genes;Genetic;Genetic Transcription;Growth;Human;In Vitro;in vivo;inhibitor;knock-down;Knock-out;Kynurenine;Label;Ligands;macromolecule;Maintenance;Malignant Neoplasms;Manuscripts;Mediating;Metabolic;Metabolic Pathway;Modeling;Molecular;Monitor;Mus;MYC gene;novel;novel strategies;nutrient absorption;Oncogenes;Oncogenic;Organoids;Pathway interactions;Physiological;Play;Preparation;prevent;Production;Proliferating;Protein Biosynthesis;Proteins;Proto-Oncogene Proteins c-myc;Regulation;Research;Ribosomes;Role;Seminal;T-Lymphocyte;Testing;Therapeutic Intervention;transcription factor;Translations;Tryptophan;tumor;tumor growth;tumor metabolism;uptake

PROJECT_TITLE: The kynurenine-AHR pathway in biomass production

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Violence Research;Youth Violence

ORG_CITY: BOSTON

PHR: PROJECT NARRATIVE Asian American parents and their children are grappling with, and making sense of, unparalleled levels of anti- Asian hatred, violence and racism; experiences that are particularly harmful for Asian American adolescents who are making sense of their ethnic identity. Yet, the evidence base for the impact of racism on mental health, chronic stress levels, parent-child conversations about race, child-peer conversations about race, and social media consumption is virtually nonexistent for Asian American adolescents. The current study employs an innovative, longitudinal, mixed methods combination of surveys, parent-child and child-peer dyadic observations, and biological markers of chronic stress to investigate the health impact of the COVID-related rise in racism targeting Asian Americans; informing researchers, public health experts, educators, parents and interventions to mitigate hard to Asian American health.

PI_NAMEs: LIU, CINDY H (contact);YIP, TIFFANY

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent Development;adolescent mental health;Adult;Affect;aged;American;anti-Asian;Anxiety;anxiety symptoms;Asian Americans;Attitude;Behavior;Belief;Biological;Biological Markers;bullying;Characteristics;Child;China;Chinese;Chinese American;Chronic stress;Climate;Clinical;combat;Communities;Conscious;COVID-19;COVID-19 impact;depressive symptoms;Development;Discrimination;Emotional;ethnic identity;Event;evidence base;experience;Exposure to;Family;Feeling suicidal;flu;Goals;Hair;harassment;Hate;Health;Hydrocortisone;Individual;innovation;Intervention;Interview;Knowledge;Learning;Longitudinal Studies;Measures;media use;Mediating;member;Mental Depression;Mental Health;Mental health promotion;Methods;Minority;Modeling;Modernization;Not Hispanic or Latino;novel;Observational Study;Outcome;parental role;Parents;peer;perceived discrimination;physical assault;Politics;Process;psychological distress;Public Health;public health relevance;Race;racial bias;racial discrimination;racial population;racism;Recording of previous events;Reporting;Research;Research Personnel;response;Risk;Science;single episode major depressive disorder;social media;Socialization;Source;suicidal;Surveys;Symptoms;Testing;theories;Time;Translations;United States;verbal;Violence;virtual;Virus;Well in self;Work;Youth

PROJECT_TITLE: Discrimination and racial socialization on Asian American parent and youth mental health

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative This inter-ADRC project seeks to validate a video-administered cognitive assessment for use by ADRCs whose in-person activities have been interrupted by the COVID-19 pandemic. This assessment battery, which incorporates a core set of the Uniform Data Set version 3 (UDSv3) measures, can also be used in future ADRC initiatives to support recruitment and retention of historically underserved populations who are less likely to travel to a metropolitan medical center for assessment.

PI_NAMEs: RAPP, STEPHEN R;SACHS, BONNIE  (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Academic Medical Centers;Achievement;Acute Respiratory Distress Syndrome;adjudication;Advisory Committees;Affect;Age;Agreement;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Assessment tool;Attention;Characteristics;Classification;Clinical;clinical care;Cognition;Cognitive;cognitive testing;COVID-19 pandemic;Data;Data Collection;Data Set;Dementia;Devices;Education;Enrollment;Episodic memory;ethnic minority;Ethnic Origin;Evaluation;executive function;Failure;Financial Hardship;Frail Elderly;Future;Geographic Locations;Geography;Goals;Individual;Interruption;Language;Measures;Medical center;meetings;metropolitan;mild cognitive impairment;Minority;Modality;Neuropsychology;older adult;Outcome;Participant;Persons;Population;preference;prevent;programs;Protocols documentation;Psychometrics;Race;racial minority;recruit;remote administration;remote assessment;remote grading;Research;response;Rural Population;satisfaction;Short-Term Memory;Site;Standardization;Subgroup;success;Tablet Computer;Telephone;Testing;tool;Transportation;Traumatic Brain Injury;Travel;Underserved Population;United States National Institutes of Health;Update;Validation;verbal;virtual;Visit;working group

PROJECT_TITLE: Validation of Video Administration of a Modified UDSv3 Cognitive Battery

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Infectious Diseases;Microbiome

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: This project will explore the underlying mechanisms controlling a class of pathways that are critical for E. coli and related bacteria to adapt to changes in the environment, such as fluctuations in oxygen availability or extracellular potassium. The insights into these systems and into the bacterial strategies for surviving changes in the environment that will emerge from this research may lead to novel therapies for controlling bacterial infections and maintaining healthy microbiomes.

PI_NAMEs: GOULIAN, MARK D (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TITLE: Phosphorelay signaling and regulation in bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Human Genome;Liver Disease;Neurosciences;Nutrition;Obesity;Sleep Research

PHR: People who work on night shifts or have circadian disruption have an increased likelihood of developing metabolic diseases including obesity and diabetes. REV-ERBs are key components of biological clocks and have important implications for understanding the links between circadian rhythm and metabolism that underlie the mechanism by which circadian misalignment exacerbates metabolic dysfunction, obesity, diabetes, and cardiovascular diseases.

PI_NAMEs: LAZAR, MITCHELL A. (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Abnormal coordination;Adult;ATAC-seq;Behavior;Behavior Control;Binding;Biological Clocks;Biology;Cardiovascular Diseases;Cell Nucleus;cell type;Cells;ChIP-seq;chromatin immunoprecipitation;circadian;circadian biology;Circadian desynchrony;Circadian Dysregulation;Circadian gene expression;circadian pacemaker;circadian regulation;Circadian Rhythms;combat;Communication;Data;Diabetes Mellitus;Dorsal;Enhancers;Epidemic;epigenome;epigenomics;Epitopes;Experimental Genetics;functional genomics;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Models;Genetic study;Genetic Transcription;genome-wide;genome-wide analysis;Genomics;Goals;Hepatic;Hepatocyte;Homeostasis;Hypothalamic structure;innovation;insight;intrahepatic;Knock-out;Knowledge;Laboratories;Learning;Ligands;Link;Liver;Mass Spectrum Analysis;Mediating;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Metabolic stress;Metabolism;metabolomics;Molecular;mouse genetics;mouse model;Mus;Neurons;novel;novel strategies;Nuclear Receptors;Obesity;Organ;Periodicity;Peripheral;Persons;Phenotype;Physiological;Physiology;Proteomics;receptor;Regulation;Repression;Role;shift work;suprachiasmatic nucleus;Testing;Tissues;transcription factor;Transcription Repressor;transcriptome;transcriptome sequencing;transcriptomics;United States;Work

PROJECT_TITLE: Biology of REV-ERB nuclear receptors

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]