ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Microbiome;Natural Products

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: Microbial interactions play key roles in maintenance of diverse ecosystems and imbalance in microbial community structure negatively impacts human health. Understanding of microbial mechanisms underlying their ability to sense and respond to competition as well as alliance will allow researchers to engineer these abilities to promote health. By using innovative and multidisciplinary approaches, we will identify and discovery new natural products that mediate niche-specific microbial interactions at the molecular, genomic, and gene expression level.

PI_NAMEs: GARG, NEHA  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Anabolism;Antibiotic Resistance;Antibiotics;antimicrobial;Bacteria;bioactive natural products;Chemicals;Communities;coral;Detection;Ecosystem;Engineering;Environment;Gene Expression;Genomics;Health;Health Promotion;Human;In Vitro;innovation;interdisciplinary approach;Maintenance;marine;Mass Spectrum Analysis;Mediating;Metabolic;Methods;microbial;microbial community;microbiome;microorganism;microorganism interaction;Molecular;Molecular Analysis;Mucous body substance;Natural product discovery;Natural Products;Nature;Observational Study;Organism;Pathway interactions;Physical environment;Play;programs;quorum sensing;Research;Research Personnel;Resources;Role;Shapes;small molecule;Source;Structure;Work

PROJECT_TITLE: Molecular analysis of bacterial interactions

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PI_NAMEs: RODRIGUEZ, ALLAN E (contact)

PROJECT_TERMS: Academic support;Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Area;Basic Science;Behavior Therapy;Behavioral;behavioral and social science;Behavioral Research;Behavioral Sciences;biobehavior;Biological;Biological Process;Caring;catalyst;Charge;Clinical;Clinical Research;Collaborations;Communicable Diseases;Communities;community advisory board;community based research;community collaboration;community engaged research;community engagement;community organizations;Community Outreach;community partnership;community setting;Complex;Consultations;demographics;Development;Ensure;Epidemic;ethnic minority;Evaluation;evidence base;expectation;Federally Qualified Health Center;Florida;Fostering;Goals;Grant;Health;health disparity;Health Resources;HIV;HIV Seropositivity;HIV/AIDS;implementation science;Individual;Infection;Infrastructure;Injectable;Injections;innovation;interdisciplinary collaboration;Interest Group;Intervention;Investigation;Leadership;Link;Medical center;Mental Health;Mentors;Methodology;Mission;Modeling;Monitor;National Institute of Mental Health;Outcome;Participant;Persons;Pharmaceutical Preparations;Population;Prevention;Prevention Research;Prevention strategy;programs;psychosocial;Public Health;Public Policy;racial minority;recruit;Research;Research Design;Research Personnel;Research Project Grants;response;retention rate;Risk;Scientist;Services;Sexual and Gender Minorities;social;social science research;Social Sciences;substance use;syndemic;System;systemic barrier;Testing;tool;transgender;Translational Research;Translations;transmission process;treatment research;treatment strategy;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Bio-Behavioral and Community Engagement Core


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Microglial cells, which are key components of the neuroinflammatory response to neuronal injury, are thought to be important mediators of retinal ganglion cell viability in glaucoma. In this application, we will critically test the importance microglia in glaucoma; furthermore, we will use advanced RNA sequencing technology to determine if there are different states of microglia—ones that are potentially beneficial or detrimental to retinal ganglion cell survival. Together, these data will determine if targeting microglial activation is a potential treatment for glaucoma.

PI_NAMEs: HOWELL, GARETH R;LIBBY, RICHARD T (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Ablation;Acceleration;Acute;age related;age related neurodegeneration;Aging;Alzheimer's Disease;Amyloid;Amyotrophic Lateral Sclerosis;Animal Model;Astrocytes;Automobile Driving;axon injury;Blindness;Brain Diseases;Cell Death;Cell Survival;cell type;Cells;Central Nervous System;Cessation of life;Chronic;Classical Complement Pathway;Complement 1q;Complex;CSF1R gene;cytokine;Data;Disease;Disease associated microglia;disorder risk;Event;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;Glaucoma;glial activation;Goals;Human Anti-Mouse Antibody;Huntington gene;IL1A gene;Immune;inhibitor;Injury;Interferons;intravitreal injection;Mediating;Mediator;Microglia;migration;Modeling;Modernization;Molecular;mouse model;Mus;Myeloid Cells;nerve damage;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuronal cell body;Neuronal Injury;neuroprotection;neurotoxic;new therapeutic target;novel;novel therapeutic intervention;Ocular Hypertension;Optic Disk;Optic Nerve;Outcome;Outcome Measure;Parkinson Disease;Pathologic;Patients;Peptide Initiation Factors;Phagocytosis;Phenotype;Physiologic Intraocular Pressure;Physiological;Play;Population;Prevalence;prevent;Process;receptor;receptor expression;Reporting;Research;response;Retina;Retinal Ganglion Cells;Risk Factors;Role;Senile Plaques;sight restoration;single cell sequencing;single-cell RNA sequencing;Site;Structure;Synapses;System;targeted treatment;Technology;Testing;therapeutic candidate;therapeutic evaluation;therapy development;TNF gene;Transcript;transcriptome sequencing;TREM2 gene;Work

PROJECT_TITLE: Dissecting the complex role of microglia states in glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Prevention;Substance Misuse

PI_NAMEs: PALLIKKUTH, SURESH  (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Administrative Supplement;Advisory Committees;Affect;age acceleration;age related;Age related comorbidities;Age Years;Aging;aging population;antiretroviral therapy;Area;Award;Basic Science;Brain;brain health;Cardiovascular Diseases;Cardiovascular system;Cells;Chronic Disease;Clinical;Clinical Research;Clinical Sciences;Clinics and Hospitals;Cognitive;Cognitive aging;Collaborations;Communities;community engagement;comorbidity;Comprehensive Cancer Center;COVID-19;COVID-19 pandemic;Data;Diabetes Mellitus;early onset;Education;Evaluation;Florida;Focus Groups;frailty;General Population;Goals;gut-brain axis;Health;Health Sciences;HIV;HIV Infections;HIV/AIDS;Immune;Immune system;Immune System Diseases;Immunity;Immunologics;Immunologist;Immunology;immunoregulation;Impaired cognition;Individual;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Investigation;Joints;Knowledge;Lead;Life;Life Expectancy;Liver;Liver diseases;Malignant Neoplasms;medical schools;meetings;Mentors;Metabolic;Microbiology;Monitor;multiple chronic conditions;Neurocognition;Neurocognitive;Neurocognitive Deficit;neuroinflammation;Neurologic;Neurologist;Personal Satisfaction;Persons;Population;Positioning Attribute;Process;programs;Public Health;Publishing;Regulation;Reporting;Research;Research Institute;Research Personnel;Research Priority;research study;Resources;response;Role;Science;Specific qualifier value;Strategic Planning;symposium;Talents;Translational Research;United States National Institutes of Health;Universities;virtual;Woman;working group

PROJECT_TITLE: HIV & Aging SWG


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Traumatic Head and Spine Injury

ORG_CITY: LOS ANGELES

ORG_NAME: SPINOGENIX, INC.

ORG_STATE: CA

PHR: Project Narrative The proposed Direct to Phase II project is to undertake GMP manufacturing of drug product and GLP toxicology studies required for an IND submission to treat Alzheimer’s disease. With the assistance of a clinical CRO, Spinogenix will prepare and submit a successful IND to the FDA.

PI_NAMEs: VANDERKLISH, PETER W (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: 3xTg-AD mouse;Academia;Address;Aducanumab;Adverse event;Agreement;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease therapy;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;Animal Model;Autopsy;Biopsy;Books;Businesses;Canis familiaris;capsule;Cardiovascular system;Characteristics;Clinic;Clinical;clinical development;Clinical Trials;Cognition;cognitive function;cognitive recovery;commercialization;Complement;Data;Dementia;Dendritic Spines;density;design;Development;Disease;Disease Progression;Dosage Forms;Dose;Economic Burden;Electronics;Elements;Etiology;Event;experimental study;Failure;Food Interactions;Formulation;Funding;Generations;genotoxicity;Glutamates;Goals;good laboratory practice;Good Manufacturing Process;Grant;Hand;Healthcare Systems;Hippocampus;Human;human old age (65+);Impaired cognition;improved;in vivo;Industry;Investigational Drugs;Lead;Lung;manufacture;member;Memory;Memory impairment;micronucleus;mild cognitive impairment;Mission;Molecular;Mus;Natural regeneration;Neurofibrillary Tangles;neurotoxicity;novel;novel strategies;Oral;Parkinson Disease;Pathology;Pathway interactions;Patients;Performance;Persons;Pharmaceutical Preparations;Pharmacology;Pharmacology and Toxicology;Pharmacology Study;Phase;Phase I Clinical Trials;Physiological;Play;postsynaptic;pre-Investigational New Drug meeting;Production;Program Development;programs;Property;prototype;Rattus;Recovery;regenerative;regenerative approach;regenerative therapy;Research;research and development;Research Support;Resources;response;Rodent Model;Role;Safety;safety testing;Senile Plaques;Small Business Innovation Research Grant;small molecule;Spinal cord injury;Suspensions;Synapses;synaptic failure;targeted treatment;tau Proteins;Testing;Therapeutic;therapeutic candidate;Time;Toxic effect;Toxicology;Transgenic Mice;Traumatic Brain Injury;Vertebral column;Work;Writing

PROJECT_TITLE: Development of a novel, regenerative therapy to reverse synapse loss in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-P(11)B]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pulmonary Hypertension;Rare Diseases

ORG_CITY: ELK GROVE

ORG_NAME: MEDLUIDICS LLC

PHR: Project narrative: Pulmonary arterial hypertension (PAH) is a rare and incurable disease, and PAH-afflicted patients die of heart failure within 5 years of diagnosis. To understand the disease and to develop therapies for PAH, scientists currently use various animal models or cells collected from patients, but these approaches have significant limitations. We recently developed a new PAH model by growing human PAH-afflicted cells in a miniaturized fluidic device, called PAH-on-a-chip. However, our prototype model cannot yet be mass-produced and made available to other researchers working on PAH who would benefit from this advanced tool. Here, we propose a way to scale up the chip fabrication process for mass production and then validate the mass-produced chips so researchers anywhere can use our device as an advantageous alternative to animal models.

PI_NAMEs: AHSAN, FAKHRUL  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: absorption;Address;Adsorption;Affect;Animal Model;Animal Welfare;Animals;arteriole;Biology;Blood Vessels;Businesses;Cardiovascular system;Cell Communication;cell growth;Cell model;cell motility;Cells;Cellular biology;Clinical;Collecting Cell;combinatorial;community engagement;Complex;Computers;Consumption;copolymer;cost;Cycloparaffins;design;Development;Devices;Diagnosis;Disadvantaged;Disease;Disproportionately impacts women;drug development;drug discovery;Drug Screening;efficacy evaluation;elastomeric;Elastomers;Endothelium;Engineering;Environmental Risk Factor;fabrication;Functional disorder;Funding;Generations;Goals;Grant;grasp;Growth;Growth Disorders;Heart failure;Human;human model;Injections;innovation;Intrinsic factor;Investigation;large scale production;Lead;Legal patent;Lesion;Liquid substance;Lung;mechanical properties;Mechanics;Medical Education;Medical Research;Medicine;Microfluidic Microchips;microfluidic technology;Microfluidics;miniaturize;Modeling;Modernization;Molds;molecular marker;Muscle;National Heart, Lung, and Blood Institute;next generation;novel;Operative Surgical Procedures;Optics;Organ;Outcome;Pathogenesis;Pathologic;Pathology;Patient Care;Patients;Pattern;Pericytes;Pharmaceutical Preparations;polydimethylsiloxane;Polymers;Precision Medicine Initiative;primary pulmonary hypertension;Process;prototype;Publishing;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary artery structure;Pulmonary Pathology;pulmonary vascular disorder;Qualifying;Reporting;Research;research and development;Research Design;Research Personnel;Resistance;scale up;Scientist;Sex Differences;sex disparity;sexual dimorphism;Smooth Muscle Myocytes;Solvents;spheroids;Study models;System;Testing;Therapeutic;therapy development;Time;tool;Treatment Efficacy;treatment response;United States National Institutes of Health;Validation;Vascular Diseases;welfare

PROJECT_TITLE: PAH-on-a-chip: a novel disease-on-a-device model for studying the pathobiology of and screening drugs for pulmonary arterial hypertension


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: MORRIS, AARON HARVEY (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Adaptive Immune System;Advisory Committees;antigen binding;Antigens;Autoimmune;Autoimmune Diseases;Autoimmunity;Award;Binding;Biocompatible Materials;Biological Markers;Biopsy;Biosensor;career;Clinical Management;Computer Analysis;Demyelinations;design;Detection;Development;Diagnostic;Disease;Disease Progression;Disease remission;Engineering;Euthanasia;experience;Fluorescence Resonance Energy Transfer;fluorophore;Gene Chips;Gene Expression;Harvest;Hydrogels;Immune;Immune response;immunoengineering;Immunologics;Immunology;Implant;implant material;in vivo;Label;Location;Machine Learning;Monitor;Multiple Sclerosis;Mus;Natural Immunity;non-invasive monitor;novel diagnostics;optical sensor;Peptides;Pharmaceutical Preparations;Physiological;Population;prevent;prognostic;Relapse;Research Personnel;scaffold;sensor;single-cell RNA sequencing;Techniques;Testing;Time;Tissue Engineering;tool;Training;Validation;Work

PROJECT_TITLE: Immulogical Niches and Non-invasive Biosensors for Autoimmune Monitoring

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes

ORG_CITY: COLUMBIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Endothelial dysfunction is a primary risk factor for the development of cardiovascular disease, the main cause of death in patients with type 2 diabetes. The proposed study will determine the role of neuraminidase activity in degrading glycocalyx structures and promoting endothelial dysfunction in type 2 diabetes.

PI_NAMEs: MARTINEZ-LEMUS, LUIS A (contact);PADILLA, JAUME

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Ablation;Animal Model;Antioxidants;Arteries;Biochemical;Biological Availability;Blood flow;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cell membrane;Characteristics;Clinical Trials;Data;Development;Diabetes Mellitus;Diameter;Disintegrins;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;experimental study;gain of function;genetic manipulation;Glycocalyx;Glycoproteins;Goals;Homeostasis;Human;human subject;Impairment;improved;Inflammatory;innovation;loss of function;Measures;mechanical force;mechanotransduction;Mediating;Membrane;Metalloproteases;Methodology;Morbidity - disease rate;mortality;Mus;Neuraminidase;new therapeutic target;Nitric Oxide;Non-Insulin-Dependent Diabetes Mellitus;novel;Oxidative Stress;Patients;pharmacologic;Phosphatidylserines;Physiological;Plasma;Play;prevent;Process;Production;Proteoglycan;Publishing;Reactive Oxygen Species;Research;response;Risk Factors;Role;shear stress;Sialic Acids;Signal Transduction;Structure;Testing;Therapeutic;Vasodilation;Vasodilator Agents;Work

PROJECT_TITLE: Role of neuraminidase activity on endothelial dysfunction in type 2 diabetes

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative p53 tumor suppressor is the most frequently mutated protein in cancer, and p53 mutation inactivates its tumor suppressor functions and/or endows oncogenic functions. Our project is relevant to public health, because it seeks to elucidate a cellular mechanism that restores the tumor suppressor functions of p53 mutants in cancer cells, which may break new ground for cancer treatment. The proposed research is relevant to the part of NCI’s mission that pertains to accelerating scientific discovery to reduce the burden of cancer and suffering of cancer patients.

PI_NAMEs: ZHANG, YUESHENG  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Acceleration;Acetylation;Affinity;Amino Acids;Automobile Driving;Binding;Biology;C-terminal;Cancer Burden;cancer cell;Cancer Patient;cancer therapy;Cell Line;Cell Nucleus;Cells;Collagen;Complex;Cytosol;Data;Dipeptidases;DNA Binding Domain;Dominant-Negative Mutation;Doxycycline;Endowment;EP300 gene;gain of function;Genes;Goals;In Vitro;in vivo;Inhibition of Cancer Cell Growth;innovation;knock-down;Malignant Neoplasms;Metabolism;Missense Mutation;Mission;Modeling;Molecular;Molecular Conformation;Mus;mutant;Mutate;Mutation;novel;Oncogenic;Outcome;patient derived xenograft model;Post-Translational Protein Processing;Process;Proline-Rich Domain;Proteins;Public Health;Reactive Oxygen Species;Regulation;Research;Role;Signal Transduction;Small Interfering RNA;Stress;System;Testing;Therapeutic;therapeutic target;Time;TP53 gene;treatment strategy;tumor;Tumor Suppressor Proteins;Xaa-Pro dipeptidase

PROJECT_TITLE: Restore the Tumor-Suppressive Activities of p53 Mutants

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Pediatric;Social Determinants of Health

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The University of California, Los Angeles proposes to serve as a Coordinating Center for the Western Region for the NIH-NIDDK NIDDK Short-Term Experience Program to Unlock Potential (STEP-UP) Program. The UCLA STEP-UP will provide an enriched summer research experience for promising high school students from underrepresented racial/ethnic minority groups as well as students from other groups underrepresented in medicine and science. The overarching goal of the UCLA STEP-UP is to prepare participating students for research careers in the biomedical and clinical health sciences.

PI_NAMEs: NORRIS, KEITH C (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: academic preparation;Affect;African American population;Alaska Native;apprenticeship;Area;Asian Pacific Islander;Basic Science;Biomedical Research;California;career;Career Exploration;Clinical;Clinical Research;college;Color;Communication;Communities;Community Health Education;Databases;design;Development;Disabled Persons;disadvantaged background;Early Intervention;Education;education research;educationally disadvantaged;effectiveness evaluation;Environment;ethnic bias;ethnic minority;ethnic minority population;Ethnic Origin;Exclusion;experience;Exposure to;Future;Gender;Goals;Health;health disparity;Health Occupations;Health Sciences;high school;High School Student;Hispanic;improved;Individual;K-12 Education;laboratory equipment;Latino;Libraries;Los Angeles;Low income;Maryland;Medicine;Mentors;Methodology;minority student;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;National origin;Native Americans;Outcome;Policies;programs;Race;racial minority;racial minority population;Reporting;Research;Research Project Grants;Resources;responsible research conduct;Science;science education;skills;socioeconomics;statistics;Structural Racism;Structure;student participation;Students;summer research;symposium;System;Talents;timeline;Translational Research;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: UCLA Short-Term Research Experience to Unlock Potential (UCLA STEP-UP)


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative This proposal is a resubmission of a renewal of a training grant that requests support for eight postdoctoral trainees at UCSD each year. The major objective of our program is to train individuals so that they have a broad- based background in cardiovascular biology. The program provides extensive research and career mentoring of trainees to equip them to become independent investigators, and tomorrow’s cardiovascular leaders.

PI_NAMEs: CHEN, JU ;ROSS, ROBERT SCOTT (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TITLE: Training in Cardiovascular Physiology and Pharmacology


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_DEPT: PSYCHOLOGY

ORG_NAME: LOYOLA MARYMOUNT UNIVERSITY

PHR: Project Narrative Recent reports suggest that exposure to alcohol-related content on popular social media (SM) platforms, such as Instagram and Snapchat, can undermine commonly used college drinking norms intervention strategies not originally intended to address the onslaught of peer generated alcohol content available on these platforms. The proposed intervention strategy innovatively utilizes ads on these SM sites to introduce a microtargeted gamified normative re-education campaign that not only has the potential to mitigate risks associated with SM-related alcohol exposure, but also reduce the cost and increase the reach of this type of normative re-education program. Over the next three years, we will develop and program an innovative, engaging, interactive, and culturally relevant gamified social norms marketing campaign (2 College Truths & 1 Lie) for first-year students during the transition into college (Phase 1) and conduct a pilot trial to evaluate the feasibility and efficacy of the program (Phase 2).

PI_NAMEs: LABRIE, JOSEPH W. (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: active control;Address;Alcohol consumption;alcohol content;alcohol exposure;alcohol intervention;alcohol risk reduction;Alcoholic beverage heavy drinker;Alcohols;Attention;Behavior;Behavior assessment;college;college drinking;combat;Communication;cost;critical period;Data;design;Development;digital;Distal;Documentation;Dose;drinking;Education;Educational Intervention;effectiveness evaluation;efficacy evaluation;efficacy trial;Esthetics;Evaluation;evidence base;experience;Exposure to;Feedback;Focus Groups;Goals;Heavy Drinking;high risk;Hybrids;Iatrogenesis;improved;Individual;innovation;Instagram;interest;Intervention;Investigation;Literature;Long-Term Effects;Marketing;Mechanics;Mediating;meetings;Methods;Modernization;National Institute on Alcohol Abuse and Alcoholism;Outcome;Participant;Patient Self-Report;peer;Perception;personalized normative feedback;Persons;Phase;pilot trial;Population;posters;prevent;Prize;programs;prospective;Prospective Studies;psychoeducation;psychologic;Randomized;Reporting;Research;Research Design;Research Methodology;Resources;response;Risk;risk mitigation;Risk Reduction;Site;social influence;social media;social norm;statistics;student drinking;student participation;Students;Surveys;Target Populations;Testing;therapy design;Time;tool;Universities;Work

PROJECT_TITLE: 2 College Truths & 1 Lie: Social Media Embedded Gamified Normative Re-education

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Dietary Supplements;Immunotherapy;Nutrition

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: Immune system is capable of suppressing cancer formation, but is often held back by tumor cells and environmental factors such as diets through immune inhibitors. We potentially identify an immune cell surface receptor for such an inhibitor and is investigating its mechanism of actions and therapeutic potential in mouse models.

PI_NAMEs: WU, DIANQING  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Acids;Address;Affect;Animals;Back;beta catenin;Binding Proteins;Biological;Biology;cancer therapy;Cause of Death;Cell Physiology;Cell surface;Cell Surface Receptors;Cells;Cellular biology;Clinical;Complex;deprivation;Development;Diet;Eicosapentaenoic Acid;Embryonic Development;Environmental Risk Factor;Essential Fatty Acids;Event;fatty acid transport;Fatty Acids;Fish Oils;follow-up;Food;Genetic;glucose metabolism;Health;Homeostasis;Human;Immune;Immune checkpoint inhibitor;Immune system;Immunologic Surveillance;immunomodulatory therapies;immunoregulation;Immunotherapy;In Vitro;in vivo;Infiltration;inhibitor;insight;interest;Investigation;Knock-out;Knockout Mice;Knowledge;Laboratories;Ligands;lipid metabolism;lipidomics;Lipids;Location;Low-Density Lipoproteins;Malignant Neoplasms;MC38;Mediating;metabolomics;mouse model;Mus;N-3 polyunsaturated fatty acid;Natural Killer Cells;neoplastic cell;NK Cell Activation;novel;Organogenesis;Pathway interactions;Phosphorylation;Phosphorylation Inhibition;Polyunsaturated Fatty Acids;Process;Proteins;Proteomics;Publishing;receptor;Regulation;Research;Role;Signal Transduction;Signaling Molecule;Specificity;stem cell biology;Testing;Therapeutic;Tissues;transcriptomics;tumor;Tumor Immunity;tumor progression;tumorigenesis;uptake;Wnt proteins;WNT Signaling Pathway

PROJECT_TITLE: A novel signaling mechanism for LRP5

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(80)S]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

PHR: PROJECT NARRATIVE More than half of low-income older adults (LOA) have maladaptive fall risk appraisal (a discrepancy between perceived fall risk versus physiological fall risk), which is a known contributor to decreased physical activity and no published study has evaluated interventions to help shift LOA with maladaptive fall risk appraisal to its healthy counterpart—adaptive (realistic) fall risk appraisal. We developed a technology-based, individualized, in-home Physio-fEedback Exercise pRogram (PEER), which includes a) physio-feedback using a real-time portable innovative technology—the BTrackS Balance System; b) cognitive reframing based on a novel fall risk appraisal matrix; and c) peer-led exercise by focusing on balance and strength training. The purposes of this clustered randomized controlled trial study are thus to: 1) examine the effects of the technology-based PEER intervention on fall risk reduction, dynamic balance and accelerometer-based physical activity; 2) examine the effects of the PEER intervention on fall risk appraisal shifting and negative self-perceptions of aging; and 3) explore participants’ experiences with the PEER intervention and potential barriers to access and adoption of the technology-based PEER intervention to inform future research.

PI_NAMEs: THIAMWONG, LADDA  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Address;Adoption;Aging;arm;Balance training;barrier to care;Categories;Cognitive;Collaborations;Communities;community living;comparison control;Control Groups;cost;Data;disability;Education;Effectiveness;Enrollment;Equilibrium;Exercise;exercise program;experience;Fall prevention;fall risk;falls;fear of falling;Feedback;follow-up;Goals;health organization;healthy aging;Home;home test;Hospitalization;implementation cost;improved;Independent Living;Injury;innovative technologies;Intention;Intervention;intervention effect;intervention program;Interview;Low income;Low Income Population;Mind;mind/body;moderate-to-vigorous physical activity;Motivation;novel;older adult;Outcome Measure;Participant;peer;Perception;Performance;personalized approach;Physical activity;Physiological;Pilot Projects;portability;prevent;Prevention program;programs;Psyche structure;Public Health;Publishing;racial diversity;Randomized, Controlled Trials;Reduce health disparities;Research;Resource-limited setting;Resources;Risk Reduction;Sampling;screening;sedentary;Self Perception;Single-Blind Study;strength training;Structure;System;Technology;technology intervention;technology platform;Time

PROJECT_TITLE: Optimizing a technology-based body and mind intervention to prevent falls and reduce health disparities in low-income populations


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: The Program Project application consists of three projects, each directed by an independent and productive investigator and with a longstanding track record of collaborations to study an important class of cell surface receptors, the integrins. The function of integrins in blood and vascular cells and the regulation of their activities and the signaling will be investigated. The information derived from these proposed studies will provide insights into the complex and biologically important responses regulated by integrins and are relevant to thrombosis, atherosclerosis and other vascular pathologies.

PI_NAMEs: QIN, JUN  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Actins;Address;Agreement;Amaze;angiogenesis;Animal Model;animal tissue;Atherosclerosis;Binding;Biological;Biological Process;Biology;Blood;Blood Cells;Blood Circulation;Blood Platelets;Blood Vessels;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular Physiology;Cell Adhesion;Cell Surface Receptors;Cell Wall;Cells;Cellular biology;Clinic;Collaborations;Complex;Cytoplasmic Tail;Cytoskeletal Modeling;Cytoskeletal Proteins;Cytoskeleton;Disease;Doctor of Medicine;Doctor of Philosophy;Endothelial Cells;Event;Faculty;Future;Gene Expression;Goals;Home;Human;Inflammation;Inflammatory;Innate Immune System;insight;Institution;Integrin beta Chains;Integrins;inter-institutional;International;Investigation;Knowledge;Lead;Leukocytes;Ligand Binding;Ligands;Ligation;Macrophage-1 Antigen;Mediating;member;Membrane Proteins;Molecular;mouse model;Mus;Mutagenesis;new therapeutic target;novel;novel diagnostics;Pathologic;Pathology;paxillin;Pericytes;Physicians;Physiological;Process;Productivity;programs;protein expression;protein purification;Publications;PubMed;Regulation;Research Personnel;Resolution;response;Role;Running;Scientist;Signal Transduction;Smooth Muscle Myocytes;Structural Biologist;Structure;Systemic Lupus Erythematosus;Talin;Thrombosis;thrombotic;translational study;transmission process;Universities;University Hospitals;Vascular Endothelial Cell;Venous Thrombosis;wound healing

PROJECT_TITLE: Cell Adhesion and Signaling in Blood and Vascular Cells

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(MA)]


PI_NAMEs: PLOW, EDWARD FRANKLIN (contact)

PROJECT_TERMS: Animal Experimentation;Biology;Blood;Blood Vessels;Cell Adhesion;Cells;Clinic;Communication;Ensure;experience;Head;human subject;Institution;medical schools;meetings;member;Principal Investigator;programs;Progress Reports;Protocols documentation;Research Institute;Research Personnel;Role;Scientist;Signal Transduction;Thrombosis;Travel;United States National Institutes of Health;University Hospitals

PROJECT_TITLE: Core A- Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Regenerative Medicine;Women's Health Research

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: NARRATIVE Over 100,000 women in the United States undergo mastectomy procedures each year due to breast cancer, resulting in total loss of breast tissue. One of the key traits of a patient's breast tissue that is often neglected in reconstruction is the nipple areolar complex, and currently there is no clinically viable solution for its reconstruction or regeneration. The long-term goal of this work is to develop a personalized, bioresorbable nipple areolar complex that will provide patients with the shape of a native nipple projection.

PI_NAMEs: FISHER, JOHN P (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Air;Anatomy;Animal Model;Appearance;Architecture;Areola;Biocompatible Materials;Biological;Biology;bioprinting;Bioreactors;Blood Vessels;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cellularity;Childhood;Clinical;clinical translation;clinically relevant;Complex;Data;design;Development;Diameter;Discipline of obstetrics;Encapsulated;Extracellular Matrix;Goals;Granulation Tissue;Growth;Gynecologic;healing;Height;Hybrids;Implant;implant design;implantation;In Vitro;in vivo;Individual;Maintenance;Malignant Breast Neoplasm;Mammaplasty;Mammary Gland Parenchyma;Mastectomy;mechanical properties;Mechanics;Natural regeneration;neglect;neovascularization;Nipples;Nutrient;Outcome;Patients;Pattern;Performance;Polymers;Porosity;Positioning Attribute;Printing;Procedures;Process;Production;Proliferating;Property;psychological distress;reconstruction;Reconstructive Surgical Procedures;Research;satisfaction;scaffold;self assembly;Shapes;Structure;subcutaneous;Supporting Cell;System;Tattooing;Testing;Texture;Time;Tissue constructs;Tissues;trait;United States;Vascularization;Water;Woman;Work

PROJECT_TITLE: 3D Bioprinted Nipple-Areolar Complex Implants


PI_NAMEs: SOLOVIEV, DMITRY ALEKSANDROVICH (contact)

PROJECT_TERMS: Address;Animal Model;animal tissue;Blood;Blood Vessels;Cell Adhesion;Cells;Complementary DNA;Elements;Equipment;experience;Goals;Human Resources;Individual;Integrins;IRAK1 gene;Laboratories;Molecular;Mutagenesis;mutant;paxillin;Physiological;Procedures;programs;protein expression;Protein Fragment;protein purification;Proteins;Reagent;Signal Transduction;Structure-Activity Relationship;Talin;Training

PROJECT_TITLE: CORE B- Animal Models and Tissue Analysis


PI_NAMEs: WANG, YUNMEI  (contact)

PROJECT_TERMS: Adopted;Animal Model;animal resource;animal tissue;Animals;Atherosclerosis;Blood;Blood Vessels;Cardiovascular Models;Cell Adhesion;Cells;Clinical;Collaborations;cost effective;Dedications;disease model;Doctor of Philosophy;Ensure;Equipment;experience;Goals;Heart Hypertrophy;in vivo;Individual;innovation;Institutional Review Boards;Laboratories;Liquid substance;Lupus Erythematosus;Modeling;mouse model;Mus;Pristane;protein expression;protein purification;Publications;Publishing;Research;Research Personnel;Research Support;Sampling;Services;Signal Transduction;skills;Specimen;Stroke;success;Technical Expertise;Techniques;Thrombosis;Tissues;Training;University Hospitals;Urine;Variant;vascular injury;Vasculitis;Venous Thrombosis

PROJECT_TITLE: CORE C- Protein Expression and Purification


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative  Real-time quaking induced conversion (RT-QuIC) assays for alpha-synuclein and tau seeds can improve diagnostic accuracy for Lewy body diseases (LBD: Parkinson’s disease, dementia with Lewy bodies) and Alzheimer’s disease (AD), but its full utility has not been elucidated. Identifying the ability of RT-QuIC to detect the presence of clinically meaningful co-pathologies and the correlation of RT-QuIC metrics with histopathologic burden and cognitive performance will allow for the comprehensive molecular characterization of LBD and AD patients during life and potentially provide a biomarker of disease activity allowing for improved clinical trial design. Here I propose to utilize existing cohorts of autopsy confirmed LBD and AD cases with antemortem CSF and/or cognitive testing to investigate the association between alpha-synuclein and tau RT-QuIC with histopathological burden and cognitive dysfunction.

PI_NAMEs: COUGHLIN, DAVID G (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Antibodies;Autopsy;Award;Biological Assay;Biological Markers;biomarker signature;Brain;California;career;Clinical;clinical diagnosis;Clinical Research;Clinical Trials Design;clinically significant;Cognition;Cognitive;cognitive performance;cognitive testing;cohort;Coupled;Dementia;Dementia with Lewy Bodies;Development;Diagnosis;diagnostic accuracy;digital;Disease;Doctor of Philosophy;Episodic memory;Epitopes;experimental study;Fellowship;Five-Year Plans;Fluorescence;Functional disorder;Future;Goals;Histologic;Histopathology;Immunohistochemistry;Impaired cognition;improved;International;K-Series Research Career Programs;Laboratories;Learning;Lewy Body Disease;Life;Measurement;Measures;Mentors;Mentorship;Methods;Molecular;molecular pathology;Motor;Movement Disorders;multimodality;Names;National Institute of Allergy and Infectious Disease;Nerve Degeneration;Neurodegenerative Disorders;neuropathology;Neuropsychology;Neurosciences;novel;Outcome;Parkinson Disease;Pathogenicity;Pathologic;Pathology;Patients;Pennsylvania;Positioning Attribute;Productivity;professor;programs;Progressive Disease;Proteins;Recording of previous events;Research;Research Support;Resources;Salmon;Sampling;Scientist;self-directed learning;Sensitivity and Specificity;skill acquisition;skills;Statistical Data Interpretation;statistical learning;Statistical Methods;tau Proteins;Techniques;Testing;Time;Tissues;TNFSF15 gene;Training;Translational Research;United States National Institutes of Health;Universities;Use of New Techniques;validation studies;Visuospatial;Western Blotting

PROJECT_TITLE: Pathological and cognitive correlations of real time quaking induced conversion in LBD and AD


PROJECT_TERMS: Actins;Adaptor Signaling Protein;Adhesions;Affect;Affinity;alpha catenin;angiogenesis;Angiogenesis Pathway;Animal Model;animal tissue;Animals;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Avidity;Binding;Binding Sites;Blood;Blood Vessels;C-terminal;cancer cell;Cardiac Myocytes;Categories;Cell Adhesion;cell fixing;cell type;Cells;Cellular biology;Chondrocytes;Classification;Collaborations;Coronary;CRISPR/Cas technology;Cytoplasmic Tail;Cytoskeleton;Data;Distal;Embryo;Endothelial Cells;Enterobacteria phage P1 Cre recombinase;extracellular;Fibroblasts;Gene Expression;Genes;Human;human disease;in vivo;insight;Integrin beta Chains;Integrins;Kidney;kidney biopsy;knock-down;Knock-out;Knowledge;Ligands;Location;Macrophage-1 Antigen;Mediating;Membrane;migration;Mus;mutant;Mutation;Mutation Analysis;nephrogenesis;novel;Patients;Pattern;Pericytes;Permeability;postnatal;Publishing;Renal function;response;Role;Signal Transduction;Site;small hairpin RNA;Smooth Muscle Myocytes;Specificity;Structure of beta Cell of islet;Structure-Activity Relationship;Systemic Lupus Erythematosus;Talin;Tamoxifen;Testing;therapeutic target;tissue fixing;transcriptome sequencing;Tube;Vascular Permeabilities;wound healing

PROJECT_TITLE: Project 1- Role of Kindlins in Blood and Vascular Cell Biology


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Pseudomonas aeruginosa (Pa) causes an array of infections that lead to high health care costs and mortality rates. In infections, Pa is frequently in microoxic environments, but how it survives and thrives in microoxia has not been well described. We propose to leverage thousands of Pa transcriptome datasets that are available in public repositories to discover novel Pa microoxic fitness factors, which may be promising therapeutic targets, and to find conditions in which these factors can be most easily studied.

PI_NAMEs: HOGAN, DEBORAH A (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Accounting;Acute Disease;Anabolism;Binding Proteins;Biological;biological adaptation to stress;Biological Assay;Bronchiectasis;Candidate Disease Gene;candidate identification;Catabolism;Cell Density;Cells;Centers for Disease Control and Prevention (U.S.);chronic infection;Chronic Obstructive Pulmonary Disease;Collaborations;Collection;Colorado;Communities;Complement;Cystic Fibrosis;Data;Data Set;Death Rate;density;Deposition;Drug resistance;Environment;environmental change;experimental study;fitness;Future;gene environment interaction;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Generations;Genes;Genetic;Genetic Diseases;genome database;Growth;Health Care Costs;Hemerythrin;improved;Individual;Infection;Infection prevention;innovation;insight;Knowledge;Label;Laboratories;Light;Machine Learning;Microbial Biofilms;Modeling;Morbidity - disease rate;mortality;multidrug-resistant Pseudomonas aeruginosa;mutant;nanomolar;Nitrates;novel;Operon;Oxidants;Oxygen;pathogen;Pathogenesis;Pathway interactions;Pattern;Phenotype;Physiology;Play;Process;Proteins;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;public repository;Publishing;Resources;respiratory;Role;Signal Transduction;Site;System;Testing;Therapeutic;therapeutic target;tool;trait;transcriptome;transcriptome sequencing;transcriptomics;transposon sequencing;Universities;Work

PROJECT_TITLE: Guided multiplex analysis of microoxic fitness factors in P. aeruginosa

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Alzheimer's disease and related dementias (ADRD) are a major public health problem, and our current diagnostic approach for biomarker confirmation of the disease does not meet the clinical need due to challenges with cost, invasiveness, and availability. This project will investigate the utility of several new blood tests for Alzheimer's disease as diagnostic screening tools in a population that represents the full spectrum of neurodegenerative diseases seen in the clinic.

PI_NAMEs: VANDEVREDE, LAWREN  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease blood test;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Area Under Curve;Autopsy;Behavioral;Benchmarking;Biological Assay;Biological Markers;biomarker discovery;biomarker validation;Blood;Blood Tests;California;career;career development;Cerebrospinal Fluid;Clinic;Clinical;clinical application;Clinical dementia rating scale;clinical diagnosis;clinical phenotype;Clinical Trials;Clinical Trials Design;clinically relevant;cohort;Communities;comorbidity;cost;Data;Dementia;design;Development Plans;Diagnostic;diagnostic accuracy;diagnostic screening;diagnostic strategy;diagnostic tool;Disease;Disease Progression;Early Diagnosis;Environment;Etiology;Frontotemporal Lobar Degenerations;Future;Generations;Goals;Image;improved;Isomerism;K-Series Research Career Programs;Light;Liquid substance;Measures;Mentors;Mentorship;mixed dementia;Modality;multidisciplinary;multimodality;Nerve Degeneration;Neurodegenerative Disorders;neurofilament;neuroimaging;neuroimaging marker;Neurologist;neuropathology;novel;novel marker;Observational Study;Parents;Participant;Pathology;Pathway interactions;patient population;Patient Recruitments;Patient Representative;Patients;Performance;PET positivity;Physicians;Plasma;Population;population based;Population Heterogeneity;Positron-Emission Tomography;professor;prospective;Public Health;Race;racial diversity;racial population;Receiver Operating Characteristics;recruit;Research;research study;Sampling;San Francisco;Scanning;Scientist;screening;Screening procedure;Senile Plaques;Site;Specimen;Sum;Syndrome;tau aggregation;tau Proteins;tau-1;Testing;Therapeutic;Time;tool;Training;Translations;Underrepresented Minority;Universities;Validation

PROJECT_TITLE: Validation of Novel Plasma Biomarkers for Mixed Etiology Dementia

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

PHR: Project Narrative The rise in the aging population and the global epidemic of obesity and diabetes will dramatically increase the prevelence of diabetic kidney disease, the most common cause of kidney failure in the United States. Novel interventions that reduce cellular senescence abundance and sterile inflammation, such as senolytics and extracellular vesicles, may alter the trajectory of this resistant disease and improve healthy lifespan. The proposed studies will 1) examine mechanisms by which extracellular vesicles affect injurious senescence and inflammation pathways, 2) test the kidney repair effects of extracellular vesicles in aging and diabetic kidney disease, and 3) assess performance of extracellular vesicles as a drug delivery system for senolytics; therein contributing to the advancement of future treatments for diabetic and age-related kidney dysfunction.

PI_NAMEs: HICKSON, LATONYA J (contact);WOLFRAM, JOY

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Address;Adverse event;Affect;Age;age related;age related deterioration;aged;Aging;aging population;aging related;Animal Model;anti aging;Anti-Inflammatory Agents;Biological Models;Biological Response Modifier Therapy;Cell Aging;Cells;Characteristics;chemokine;Chronic Kidney Failure;Clinic;Clinical;clinical translation;Clinical Trials;Combined Modality Therapy;cytokine;Dasatinib;Data;delivery vehicle;Deterioration;Diabetes Mellitus;diabetic;Diabetic Nephropathy;digital;Disease;disease model;Disease Progression;Disease Resistance;Dose;End stage renal failure;Ensure;extend lifespan;extracellular vesicles;Filtration;Future;glucose transport;glycemic control;Goals;Growth;healthspan;Human;Hyperglycemia;immune modulating agents;improved;In Vitro;Incidence;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury to Kidney;insight;Intervention;Kidney;Kidney Diseases;kidney dysfunction;Kidney Failure;kidney repair;Knowledge;Macrophage;Mediating;mesenchymal stromal cell;Methods;MicroRNAs;mouse model;Mus;nano-string;novel;novel strategies;novel therapeutics;obese person;Obesity;Obesity Epidemic;Onset of illness;Organ;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Performance;Persons;pre-clinical;Predisposition;Process;Prognosis;Quercetin;secretory protein;senescence;senescent cell;senolytics;Senotherapeutic;side effect;small molecule;Source;Sterility;Subgroup;success;System;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Time;Tissues;Treatment Efficacy;United States;Uremia;Work

PROJECT_TITLE: Extracellular vesicle-based senotherapeutics for aging diabetic kidneydisease

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


PROJECT_TITLE: Project 2- Mechanistic Role of Talin in Cellular Signaling


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: SAN DIEGO

ORG_NAME: ALIDA BIOSCIENCES, INC.

PHR: Project Narrative Alida Biosciences is a start-up company focused on reading the epitranscriptomic code, a regulatory layer of biological information controlling how the genetic code is used in cells in health and in disease progression. By creating and commercializing the first platform for reading multiple elements of this epitranscriptomic code simultaneously, we will enable new science to understand the progression of diseases such as cancer and accelerate drug development targeting epitranscriptomic pathways.

PI_NAMEs: STENGEL, GUDRUN  (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: Acceleration;Active Sites;Alternative Splicing;analysis pipeline;analytical method;Antibodies;Architecture;Bar Codes;Benchmarking;Binding;Biological;Biological Assay;Biological Sciences;Cells;Chemicals;Chimeric Proteins;Clinical;Code;commercialization;Custom;Data;Data Set;design;Detection;detection assay;detection limit;Development;Disease;Disease Progression;DNA;drug development;Drug resistance;Drug Targeting;Elements;Engineering;Environmental Risk Factor;Enzymes;epitranscriptome;epitranscriptomics;Evaluation;Exhibits;Feedback;Funding;Genetic Code;Goals;Grant;Health;Heteroduplex DNA;Human;Human Cell Line;improved;Individual;interest;Libraries;Location;Malignant Neoplasms;Maps;Marketing;Measures;Messenger RNA;Methods;Modification;molecular recognition;Monitor;Mutagenesis;nano;Needle biopsy procedure;next generation sequencing;novel strategies;Nucleotides;Pathway interactions;Performance;Phase;Phenotype;Play;posttranscriptional;Procedures;Process;Proteins;Protocols documentation;prototype;Publishing;Questionnaires;rational design;Reader;Reading;Reagent;Reproducibility;Reverse Transcription;Ribosomal RNA;RNA;RNA Degradation;Role;Running;Sampling;Science;Site;Small Business Innovation Research Grant;Specificity;Standardization;Structure;Technology;Testing;Time;Tn5 transposase;trafficking;transcriptome;Transfer RNA;Translation Initiation;Translations;Transposase;tumor progression;usability;user-friendly;Validation;Variant;Virus Diseases

PROJECT_TITLE: Rapid NGS Method for Mapping of the Epitranscriptome


ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Overall Narrative/Summary Our research focuses on understanding the mechanisms that lead individuals to develop Alzheimer’s disease (AD). There is agreement among researchers that astrogliosis, a form of inflammation) plays a critical role in the mechanism of AD but measurement in the living brain has been challenging. The present PPG proposes to explore the relationship of astrogliosis to AD pathology and AD risk factors using a combination of state-of-the- art neuroimaging, clinical, blood biomarker (and neuropathological tools.

PI_NAMEs: AIZENSTEIN, HOWARD J;COHEN, ANN D. (contact);IKONOMOVIC, MILOS D;VILLEMAGNE, VICTOR LUIS

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Abeta clearance;abeta deposition;Acceleration;Address;Affinity;Age;Aging;Agreement;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Amyloid deposition;astrogliosis;Autopsy;Autoradiography;Binding;Biochemical;Biological Markers;Blood;Blood - brain barrier anatomy;Blood Vessels;Brain;cardiovascular risk factor;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrum;Clinical;Cognition;cohort;Complex;Data;Dementia;Deposition;Development;Disease;Disease Marker;Evaluation;Event;follow-up;Functional disorder;glial activation;Glial Fibrillary Acidic Protein;Gliosis;Grain;Health;Image;Impaired cognition;In Vitro;in vivo;Individual;Inflammation;Inflammatory Response;innovation;Knowledge;Lead;Ligands;Link;Liquid substance;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Microglia;Monoamine Oxidase B;MRI Scans;Nerve Degeneration;neuroimaging;neuropathology;Neuropsychology;novel;Participant;Pathologic;Pathology;Pathway interactions;Phase;Physiological;Plasma;Play;poor sleep;Positron-Emission Tomography;pre-clinical;Process;Proxy;radioligand;regional difference;Research;Research Personnel;resilience;Risk Factors;Role;Selegiline;Severities;Sleep;Sleep Deprivation;Structure;Symptoms;Synapses;tau Proteins;tau-1;Techniques;Technology;Testing;tool;Tracer;validation studies;Vascular Diseases

PROJECT_TITLE: The role of astrogliosis in aging and the pathological and clinical progression of Alzheimer's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: COHEN, ANN D. (contact)

PROJECT_TERMS: Administrator;Aging;Alzheimer's Disease;astrogliosis;Basic Science;Budgets;Clinical;Clinical Research;Clinical Sciences;Communication;Conflict of Interest;conflict resolution;cost;Data;data sharing;Databases;Education;Ensure;Expenditure;experience;Funding;Human Subject Research;Institution;Leadership;meetings;Monitor;Neurology;Office for Human Research Protections;operation;organizational structure;Participant;Pathologic;Policies;Procedures;programs;recruit;Registries;Reporting;Research;Research Personnel;Research Project Grants;Resources;Role;Schedule;Source;statistics;success;Supervision;Technology;Translational Research;United States Food and Drug Administration;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lupus

PI_NAMEs: SIMON, DANIEL I (contact)

PROJECT_TERMS: Acute;Adaptive Immune System;Adhesives;Affect;African American;Arterial Injury;Arthritis;Attenuated;Autoantibodies;Autoimmune Diseases;Binding;Binding Sites;Biochemical;Biological Markers;Blood;Blood Platelets;Blood Vessels;Brain;Cardiovascular Diseases;Cell Adhesion;Cell Adhesion Molecules;Cells;chronic pain;Clinical;Cognitive;Collaborations;Complex;Cytoplasmic Tail;Cytotoxic agent;Deposition;Development;Disease;disease model;Exanthema;experience;experimental study;extracellular;Fatigue;Flare;forkhead protein;FOXP1 gene;Functional disorder;Generations;Glomerulonephritis;Hair;health disparity;Hemostatic function;Hispanic;Immune System Diseases;Immunosuppressive Agents;Impairment;in vivo;Inflammasome;Inflammation;Inflammatory;Innate Immune System;insight;Integrins;Interruption;IRAK1 gene;ITGAM gene;ITGB2 gene;Joints;Kidney;Laboratories;Lasers;Leukocytes;Ligand Binding;Ligation;Lung;Lupus;Macrophage;Macrophage-1 Antigen;Mediating;Methods;Microcirculation;Modeling;Molecular;Monoclonal Antibodies;monocyte;mouse model;Multiple Sclerosis;Mus;mutant;Nature;neutrophil;novel;novel therapeutics;Nuclear;Observational Study;Organ;Pain;Pathogenesis;Patient Agents;Patients;Peptides;physical impairment;Population;Prevalence;Prevention;Process;receptor;recruit;Reporting;response;restenosis;Role;Serum;Signal Transduction;Site;Skin;Stable Disease;Stroke;Structure;Survival Rate;Symptoms;Systemic disease;Systemic Lupus Erythematosus;Talin;Therapeutic immunosuppression;therapeutically effective;Thrombosis;Tissues;vascular injury;Vasculitis;Venous;Venous Thrombosis;White Women;Woman

PROJECT_TITLE: Project 3- Role of Leukocyte-Platelet Interactions in Inflammation and Thrombosis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Sleep Research

PI_NAMEs: SNITZ, BETH  (contact)

PROJECT_TERMS: actigraphy;adjudication;Age;Aging;Alzheimer's Disease;Ankle;arterial stiffness;arterial tonometry;astrogliosis;Autopsy;Behavior;Behavioral;Biological Markers;Biometry;Blood Vessels;Brain;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Carotid Arteries;Classification;Clinic;Clinical;Clinical assessments;clinical imaging;Clinical Research;clinically relevant;Cognition;Cognitive;cognitive performance;cognitive testing;cohort;Communities;comorbidity;computerized;Consensus;Consent;daily functioning;Data;data management;Data Reporting;Dementia;depressive symptoms;Diagnosis;Diagnostic;diaries;Enrollment;Ensure;Evaluation;experience;follow-up;Goals;health assessment;Home;Image;imaging biomarker;indexing;informant;Infrastructure;Liquid substance;Logistics;Measures;Medial;Medical;Medical History;Memory;Methodology;mild cognitive impairment;Moods;multidisciplinary;Neurologic;Neurologic Examination;Neurologist;Neuropsychological Tests;Neuropsychology;older adult;operation;Organ;organizational structure;Outcome;Participant;participant enrollment;Pathologic;Patient Recruitments;Patient Self-Report;Performance;Peripheral;Pharmaceutical Preparations;Physiologic pulse;Polysomnography;Program Research Project Grants;programs;recruit;Registries;Reporting;Research;research clinical testing;Risk;Role;Running;Schedule;Self Administration;Sleep;Sleep Apnea Syndromes;Source;Standardization;Stratification;symposium;Thick;Time;Ultrasonography;United States National Institutes of Health;Universities;Vascular Endothelium;Visit;volunteer;Work

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NATIONAL OPINION RESEARCH CENTER

ORG_STATE: IL

PHR: Project Narrative The National Social Life, Health, and Aging Project (NSHAP) is a longitudinal study linking social, cognitive, physical, and mental health trajectories among older adults (born 1920-1965) and their coresident spouses and romantic partners. As a follow up to NS HAP Round 4 (conducted 2021-22 with all Cohort 1 and Cohort 2 respondents), NSHAP Rounds 4.2 and 4.4 will produce two critical datasets, fielded two years apart, with the subset of 1,500 NSHAP respondents identified as having higher risk of mortality or who are demographically matched but have lower mortality risk, for comparison. Including all Black and Hispanic respondents from past rounds of NSHAP and adding new measures that are culturally attuned to the experiences of Black and Hispanic older adults will provide the scientific community, clinicians, policymakers, and the public valuable data on health problems impacting older adults, including cognitive decline and Alzheimer's Disease and Related Dementias (ADRD) among others.

PI_NAMEs: WAITE, LINDA J (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, JOHN

PROJECT_TERMS: Accelerometer;Age;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Biological;Black Populations;Black race;career;Cessation of life;clinical diagnosis;Cognition;Cognitive;cognitive function;cohort;Collection;Communities;Control Groups;Data;data harmonization;Data Set;design;Dimensions;Disablement;end of life;ethnic difference;ethnic disparity;Event;experience;follow-up;frailty;Future;Health;Health Status;high risk;Hispanic;Hispanic Populations;human old age (65+);Impaired cognition;Individual;informant;innovation;Interview;Life;Life Cycle Stages;Link;Literature;Longitudinal Studies;Measures;Mediating;Mental Health;Morality;mortality;mortality risk;older adult;Pattern;Periodicity;Personal Satisfaction;Persons;Pharmaceutical Preparations;physical conditioning;Policy Maker;Polypharmacy;predictive modeling;Probability Samples;Protocols documentation;Proxy;Psyche structure;racial difference;racial disparity;rate of change;Research;Research Design;Research Personnel;Respondent;Retrospective Studies;Risk;Sampling;Sensory;Sleep;social;social factors;Social Network;Social Well-Being;Spouses;Structural Models;Testing;Update

PROJECT_TITLE: National Social Life, Health, and Aging Project: Rounds 4.2 and 4.4

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Hematology;Infectious Diseases;Influenza;Microbiome;Nutrition;Pneumonia and Influenza

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Abnormal and potentially life-threatening blood clotting is seen in other severe infections, such as SARS- CoV-2, MERS, and H1N1 influenza, but the regulation of platelet-producing megakaryocytes is poorly understood. Our recent study suggests a novel role for gut bacteria-derived metabolites in limiting the coagulation response by dampening megakaryopoiesis and platelet turnover. This proposal will define the role of the gut microbiome in the regulation of megakaryocyte maturation and function at steady state and in viral infection, and potentially identify gut microbiome-based therapies (probiotics and diet) to optimize megakaryocyte function and coagulation in infection and other disease settings.

PI_NAMEs: ZENG, MELODY Y (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: 2019-nCoV;ACE2;Antibiotics;Autoimmune Diseases;Bacteria;Biological Markers;Blood coagulation;Blood flow;Blood Platelets;Bone Marrow;Bone Marrow Cells;Cancer Patient;Coagulation Process;commensal bacteria;COVID-19 pandemic;COVID-19 patient;Data;Diet;Disease;Fermentation;Fiber;Germ-Free;Goals;gut bacteria;gut microbiome;gut microbiota;Hamsters;Heterogeneity;Histone Deacetylase;Homeostasis;Human;Impairment;Infection;Influenza;Influenza A Virus, H1N1 Subtype;influenza infection;interest;Knowledge;Life;Ligands;Link;Long COVID;Lung;Mediating;Megakaryocytes;Megakaryocytopoieses;microbial;microbiome therapeutics;Microscopic;Middle East Respiratory Syndrome;Morbidity - disease rate;mortality;mouse model;Mus;neutrophil;novel;Oxygen;Pathway interactions;Patients;Pectins;Predisposition;Probiotics;progenitor;receptor;Regulation;Reporting;response;Rheumatoid Arthritis;risk prediction;Risk Reduction;Role;SARS-CoV-2 infection;SARS-CoV-2 spike protein;severe COVID-19;Shapes;Signal Transduction;single-cell RNA sequencing;Systemic Lupus Erythematosus;Testing;therapeutic development;Thrombosis;Tissues;transcriptomics;transmission process;Viral Load result;Virus Diseases;Volatile Fatty Acids;Work

PROJECT_TITLE: Megakaryocyte regulation by the gut microbiome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMII-U(01)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: LOPRESTI, BRIAN J (contact)

PROJECT_TERMS: Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Anatomy;astrogliosis;Autopsy;Autoradiography;Binding;Biochemical;Biometry;Blood Vessels;Brain;burden of illness;cardiovascular risk factor;Cerebrovascular Disorders;Clinical;Cognition;cohort;Data;data acquisition;Data Analyses;data dissemination;data management;Deposition;Disease;Elderly;Evolution;Faculty;Functional Imaging;Funding;Glial Fibrillary Acidic Protein;Goals;Grain;Health;Image;Image Analysis;image reconstruction;imaging biomarker;Imaging Device;imaging modality;imaging study;In Vitro;indexing;Individual;Infrastructure;instrumentation;Leadership;Lesion;Liquid substance;Magnetic Resonance Imaging;Measures;Mediating;meetings;method development;Methodology;Methods;Mission;Monoamine Oxidase B;Nerve Degeneration;neuroimaging;novel;Outcome;Participant;Pathologic;Pathology;Pathway interactions;Positioning Attribute;Positron-Emission Tomography;Postdoctoral Fellow;pre-clinical;Process;Prospective cohort;Quality Control;regional difference;Research;Research Personnel;Research Support;Resources;Risk Factors;Role;Sleep;Statistical Data Interpretation;statistics;Students;Synapses;task analysis;tau Proteins;Technical Expertise;Thick;Time;Training;Universities;Vascular Diseases

PROJECT_TITLE: Imaging Biomarker Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: PASCOAL, THARICK  (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;Amyloid beta-42;Amyloid beta-Protein;astrogliosis;Autopsy;beta amyloid pathology;Big Data;Biological Assay;Biological Markers;Blood;Brain;Brain Pathology;cardiovascular risk factor;Cerebrovascular Disorders;Characteristics;Clinical;Clinical assessments;clinical practice;cohort;Collaborations;Collection;Communities;Complement;Complex;cost effective;Data;Data Set;Ensure;Faculty;follow-up;Functional disorder;Goals;imaging biomarker;Impaired cognition;in vivo;inflammatory marker;Knowledge;large scale data;Light;Link;Liquid substance;longitudinal dataset;Measurement;Measures;meetings;member;Methodology;Methods;Nerve Degeneration;neurofilament;neuroimaging;neuroimaging marker;neuroinflammation;neuropathology;novel;organizational structure;Outcome;Pathologic;Pathology;Peripheral;Plasma;Positioning Attribute;Postdoctoral Fellow;Procedures;Research;Research Personnel;response;Role;Site;Sleep Disorders;Standardization;student training;tau Proteins;tau-1;Techniques;Testing;Validation

PROJECT_TITLE: Fluid Biomarker Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE (relevance to health) Osteoarthritis (OA) is worldwide a major source of chronic pain, and current treatments are insufficient. In depth study of the relationship between pain and structural changes in joint tissues, including changes in joint innervation, will have a major impact on development of more efficacious and safe treatments for OA.

PI_NAMEs: MALFAIT, ANNE-MARIE  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Address;Adult;Afferent Neurons;Affinity;aged;Aging;Analgesics;Anatomy;Antibodies;Arthralgia;Arthritis;AVIL gene;Behavior;Binding;Biological Assay;Biological Response Modifier Therapy;biophysical techniques;bone;Bone remodeling;Bone Spur;Cells;Characteristics;Chondrocytes;chronic pain;Clinical Trials;conditional knockout;Data;Degenerative polyarthritis;Development;Disease;Dissociation;Embryonic Development;experimental study;Female;Fracture;Funding;Generations;Growth;Health;Histology;Homeostasis;Human;Hyperalgesia;Image;Immunohistochemistry;In Situ Hybridization;in vivo;insight;Intra-Articular Injections;joint injury;Joints;Knee;Knockout Mice;Knowledge;Literature;Long-Term Effects;Macrophage;male;mechanical load;Medial meniscus structure;Mediator;microCT;Molecular;Monitor;mouse model;Mus;Myeloid Cells;Nerve;Nerve Growth Factors;nerve supply;Neuroanatomy;neurobiological mechanism;Neuroglia;neuronal growth;Neuronal Plasticity;Neurons;neurotrophic factor;neutralizing antibody;Nociception;Nociceptors;novel;Operative Surgical Procedures;Organ;osteoarthritis pain;Osteoblasts;Osteoclasts;Outcome;Pain;pain behavior;Pain Measurement;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphotransferases;preservation;prevent;prophylactic;receptor;Replacement Arthroplasty;Reporter;Resources;response;Role;Signal Transduction;single-cell RNA sequencing;Source;spatiotemporal;Spinal Ganglia;subchondral bone;Surgical Models;Synovial Membrane;Synovitis;Testing;Therapeutic;Tissues;transcriptome sequencing;Tropomyosin

PROJECT_TITLE: Molecular Pathways of Pain Generation in Osteoarthritis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: TUDORASCU, DANA L (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Area;astrogliosis;Biological Markers;Biometry;Blood;burden of illness;Cerebrovascular Disorders;Clinical;clinical translation;Cognitive;cohort;Collaborations;Collection;computer science;computerized data processing;Data;Data Analyses;Data Element;Data Files;data integration;data management;data resource;Data Set;Database Management Systems;Databases;design;Development;Disease Pathway;Disease Progression;distributed data;Doctor of Philosophy;Early identification;Ensure;Etiology;experience;Faculty;Future;Goals;graduate student;high dimensionality;Image;imaging biomarker;Impaired cognition;Individual;Information Systems;Instruction;interest;Lead;lectures;Linear Regressions;longitudinal analysis;Machine Learning;Magnetic Resonance Imaging;Measures;meetings;Methodology;Methods;mid-career faculty;mild cognitive impairment;Mission;Modality;Neurobehavioral Manifestations;neuroimaging;next generation;Outcome;Participant;Pathogenesis;Pathologic;Persons;Play;Population;Positron-Emission Tomography;Postdoctoral Fellow;Preparation;Prevention;Process;Program Research Project Grants;programs;Psychiatry;Publishing;Reporting;Reproducibility;Research;Research Personnel;Research Support;Resources;Rest;Role;Scientist;Series;Source;Specific qualifier value;Statistical Data Interpretation;Statistical Methods;Statistical Models;statistics;Students;Testing;theories;Thick;Training;Training and Education;Universities;Work

PROJECT_TITLE: Biostatistics and Data Management Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: VILLEMAGNE, VICTOR LUIS (contact)

PROJECT_TERMS: abeta accumulation;Acceleration;Acids;Address;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;astrogliosis;Binding;Biochemical;Blood;Brain;Brain region;Cardiovascular system;Cerebrovascular Disorders;Clinical;Cognition;Cognitive;cognitive disability;cohort;Complement;Data;Dementia;Deposition;Development;Diagnostic;Disease;Dose;early onset;Economics;Education;Elderly;Evaluation;Family;Functional disorder;Glial Fibrillary Acidic Protein;Gliosis;Image;Impaired cognition;in vivo;in vivo imaging;indexing;Individual;inflammatory marker;Label;Light;Link;Long-Term Effects;longitudinal analysis;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Monoamine Oxidase B;Nerve Degeneration;Neurobehavioral Manifestations;neurofilament;neuroimaging;neuroimaging marker;Neuroimmune;neurotoxic;non-demented;novel;Participant;Pathologic;Pathology;Patients;Peripheral;Phenotype;Plasma;Positioning Attribute;Positron-Emission Tomography;pre-clinical;Prevention strategy;Primary Prevention;Process;prognostic;Proteins;radiotracer;rate of change;Resources;response;Risk;Role;Secondary Prevention;Series;sex;Sleep;Societies;Staging;Structure;Surrogate Markers;Symptoms;tau Proteins;tau-1;Techniques;Testing;Time;Tracer;Translating;Validation;Vascular Diseases;Work

PROJECT_TITLE: In vivo imaging of reactive astrogliosis along the Alzheimer's disease continuum


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Interstitial Cystitis;Neurosciences;Pain Research;Urologic Diseases

ORG_CITY: Aurora

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proper level of excitability of bladder sensory afferents is essential for sensing bladder filling and urine chemical composition. Bladder afferent hypersensitivity induced by injury, inflammation, or during neurodegeneration causes urinary urgency, frequency, and pelvic pain which impact millions of Americans. The current proposal aims to examine the analgesic role of peripheral sensory glial cells in decreasing primary afferent sensitivity and reversing inflammation-induced visceral pain and bladder overactivity in mice, which will markedly expand our knowledge on the roles of peripheral glial cells in regulating bladder function.

PI_NAMEs: XIE, XIAOQIAO  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Absence of pain sensation;Adenosine A1 Receptor;adenosine receptor activation;Adenosine Triphosphate;Afferent Neurons;Affinity Chromatography;American;Analgesics;Animal Model;Bladder;Bladder Control;Bladder Dysfunction;Chemicals;Chronic Disease;chronic pain;chronic pain management;chronic painful condition;chronic pelvic pain;Chronic Phase;Clinical Trials;Communities;Creativeness;Data;Dependence;design;Disease;Dose;effective therapy;Elements;experience;experimental study;Frequencies;Functional disorder;G alpha q Protein;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gastrointestinal;gene therapy;gene-targeted therapy;genetic analysis;genetic manipulation;Glial Fibrillary Acidic Protein;Goals;high reward;high risk;Hyperalgesia;Hypersensitivity;In Situ;in vivo;Increased frequency of micturition;Individual;Inflammation;Injury;Knowledge;Link;lower urinary tract symptoms;Maintenance;Mechanics;Messenger RNA;micturition urgency;Modeling;Molecular;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nerve Degeneration;Neuroglia;neuronal excitability;Neurons;neuroregulation;neurotransmission;Nociception;novel therapeutics;Pain;pain behavior;Pathogenesis;Pathologic;Patients;Pelvic Pain;Pelvis;Peripheral;Peripheral Nervous System;Pharmacogenetics;Pharmacotherapy;Physiological;Physiology;preclinical trial;prevent;Protocols documentation;Purinergic P1 Receptors;receptor;Receptor Activation;reduce symptoms;Regulation;Reporting;Research;response;Ribosomes;Role;Sensory;Sensory Ganglia;Signal Pathway;Signal Transduction;Symptoms;Technology;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Time;Translating;translatome;treatment strategy;Urination;Urine;urologic chronic pelvic pain syndrome;Urology;Visceral;Visceral pain

PROJECT_TITLE: Activating Peripheral Glia to Relieve Visceral Pain in Animal Models of Urological Chronic Pelvic Pain Syndrome (UCPPS)

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Sleep Research

PROJECT_TERMS: abeta deposition;Acceleration;actigraphy;Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;arterial stiffness;astrogliosis;Beds;Blood Pressure;Blood Vessels;Brain;cardiovascular risk factor;Cerebrospinal Fluid;Cerebrovascular Disorders;Cholesterol Homeostasis;Chronic;Clinical;Cognitive;cognitive function;cytokine;Data;Dementia;dementia risk;Disease;forgetting;Functional disorder;glial activation;Glial Fibrillary Acidic Protein;Gliosis;Goals;Health;human old age (65+);Hypertension;Image;Immune;Impaired cognition;Inflammation;Inflammatory;interstitial;Kinetics;late life;Lesion;Link;Measures;Mediating;Mediator;Memory;middle age;Nerve Degeneration;neuroinflammation;Neuronal Dysfunction;non rapid eye movement;older adult;Participant;Pathologic;Pathology;Pathway interactions;Peripheral;Physiological;Pittsburgh Compound-B;Plasma;Play;Polysomnography;poor sleep;Positron-Emission Tomography;Process;programs;Pulse Pressure;Risk;Risk Factors;Role;Sleep;Sleep Deprivation;Sleep disturbances;sleep quality;stroke risk;Structure;tau Proteins;Testing;Time;white matter;β-amyloid burden

PROJECT_TITLE: The relationship of AD risk factors to reactive astrogliosis along the Alzheimer's disease continuum


PI_NAMEs: AIZENSTEIN, HOWARD J (contact)

PROJECT_TERMS: abeta accumulation;Abeta clearance;abeta deposition;Age;Aging;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Animal Model;aquaporin 4;arteriole;Astrocytes;astrogliosis;Autopsy;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier permeabilization;Brain;brain dysfunction;Brain imaging;Cardiac;cerebrovascular;Cerebrum;Clinical;cohort;Collaborations;Data;Deposition;Descriptor;design;detection sensitivity;Echo-Planar Imaging;Evaluation;fluid flow;follow-up;foot;Frequencies;Functional disorder;Future;Goals;Head;Human;Image;Impaired cognition;Impairment;improved;in vivo;innovation;interstitial;Length;Liquid substance;Magnetic Resonance Imaging;Measures;Mediating;Methods;Monoamine Oxidase B;monomer;Morphology;multimodality;neuroimaging;neuroimaging marker;Neurons;novel;older adult;Participant;Pathologic;Pathway interactions;Physiologic pulse;Physiological;Play;Positron-Emission Tomography;predictive modeling;prevent;Process;quantitative imaging;radio frequency;radiotracer;respiratory;Role;Senile Plaques;Study models;targeted treatment;temporal measurement;Testing;Tracer;vasomotion;Ventricular;Water;water channel;Width;β-amyloid burden

PROJECT_TITLE: Imaging brain fluid dynamics in relation to reactive astrogliosis and cerebral amyloid accumulation


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Services;Kidney Disease

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative  When a person is found to have a mass that is localized to their kidney (LRM), they face many choices on what to do about it, but their doctors can offer little advice since there is little guidance from prior studies. To address this, we will first create a database between three different academic hospital systems that gathers all known information about the health of the patient and the LRM. This information can then be used to create specific treatment pathways that can help the doctor and patient decide what is best for the patient, particularly in terms of treating the cancer while trying to save the function of their kidney and minimize side effects.

PI_NAMEs: CULP, STEPHEN HEMBREE;LOBO, JENNIFER MASON (contact)

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Address;Affect;Age;Algorithms;Benign;Biopsy;California;cancer cell;Cancer Control;Cancer Intervention;Characteristics;Clinical;cohort;Collaborations;Communities;community academic partnership;community partnership;Community Practice;comorbidity;Complex;Confusion;cost;cost comparison;Data;Data Analyses;Data Collection;Data Set;Databases;Decision Making;Detection;Development;Diagnosis;Disease Progression;expectation;Expert Opinion;Face;Feedback;functional decline;Future;Gender;geographic difference;Geography;Goals;Health;Health Care Costs;health care service utilization;Health system;Healthcare;Heating;Histology;Hospitals;Image;Impairment;Individual;individual patient;Institution;Internet;intervention cost;Kidney;kidney cell;Learning;Left;Life;Malignant - descriptor;Malignant Neoplasms;markov model;Medical;Medical center;Modality;Modeling;multidisciplinary;Needles;Nephrectomy;novel therapeutics;Older Population;Online Systems;Operative Surgical Procedures;Outcome;Pathologic;Pathway interactions;patient oriented;Patient Preferences;patient variability;Patient-Focused Outcomes;Patients;personalized care;personalized management;Persons;preservation;Process;prospective;prototype;Provider;Quality of life;Recommendation;Renal Cell Carcinoma;Renal function;Renal Mass;Resources;Rest;Risk;San Francisco;Secure;shared database;shared decision making;side effect;Surveys;System;Thermal Ablation Therapy;tool;Translations;treatment effect;treatment optimization;treatment planning;Triage;tumor;Uncertainty;Universities;Urologist;usability;Validation;Variant;Virginia;web based interface;web-based assessment;web-based tool;willingness;Wisconsin;Work

PROJECT_TITLE: Optimizing Treatment Decision Making for Patients with Localized Renal Mass

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: IKONOMOVIC, MILOS D (contact)

PROJECT_TERMS: Affinity;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Amyloidosis;aquaporin 4;Area;Astrocytes;astrogliosis;Autopsy;Autoradiography;beta amyloid pathology;Binding;Biochemical;Biological Assay;Biological Markers;Blood;Blood - brain barrier anatomy;Blood specimen;Blood Vessels;Brain;Brain region;brain tissue;cingulate cortex;Clinical;Cognition;Cognitive;cytokine;Dendritic Spines;density;Disease;Enzyme-Linked Immunosorbent Assay;Enzymes;Evaluation;Extravasation;Freezing;Glial Fibrillary Acidic Protein;Goals;Harvest;Image;imaging biomarker;Imaging ligands;Immunohistochemistry;immunoreactivity;Impaired cognition;Impairment;In Vitro;Inflammation;Inflammatory;interest;Knowledge;Ligands;Liquid substance;Magnetic Resonance Imaging;Measures;Monoamine Oxidase B;neural circuit;Neurodegenerative Disorders;neuroimaging;neuropathology;novel;older adult;Participant;Pathogenesis;Pathologic;Pathology;Pattern;PET positivity;Phenotype;Positron-Emission Tomography;Production;Proteins;Proteomics;radioligand;radiotracer;Resources;Role;Senile Plaques;Series;Serum Proteins;Severities;Signal Transduction;Synapses;tau Proteins;Testing;Validation;validation studies;Variant;Western Blotting;β-amyloid burden

PROJECT_TITLE: Neuropathological correlates of the SMBT-1 PET ligand for imaging astrogliosis in Alzheimer's disease


ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: HPV associated cancers are significant causes of morbidity and mortality and are not decreasing with the use of antiretroviral therapy, as has been seen with other HIV-associated malignancies. As WHO strives to eliminate cervical cancer globally, and African nations reach out to MSM populations to engage them in care, developing a regional hub for translational research in HPV/HIV associated cancers in Rwanda and DRC, will be a key resource in understanding how to mitigate the impact of HIV and HPV on the health of Africans.

PI_NAMEs: ADEDIMEJI, ADEBOLA ;ANASTOS, KATHRYN M. (contact);MUTESA, LEON ;YOTEBIENG, MARCEL

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Africa;Africa South of the Sahara;African;aging related disease;AIDS prevention;AIDS related cancer;antiretroviral therapy;Anus;Bacteria;burden of illness;cancer epidemiology;Cancer Etiology;career development;Career Mobility;Caring;Cervical;Cervical Cancer Screening;cervicovaginal;cervicovaginal microbiome;Clinical;Clinical Research;clinical translation;Collaborations;college;Colorectal;Congo;Country;Data;Decision Making;Democratic Republic of the Congo;Development;Disease;Disease Progression;disorder prevention;Doctor of Philosophy;dysbiosis;Effectiveness;effectiveness evaluation;Epidemic;Epidemiology;evidence base;experience;Financial Support;flexibility;follow-up;Fostering;Freezing;Funding;Growth;gut microbiome;Head and Neck Cancer;Health;Histopathology;HIV;HIV Infections;Human;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 6;Immune response;improved;Incidence;Infection;Inflammatory;Infrastructure;infrastructure development;Institution;Kaposi Sarcoma;Knowledge;Laboratories;Leadership;Lesion;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medicine;men;men who have sex with men;Mentors;Methods;microbiota;Military Hospitals;Mission;Molecular Diagnostic Testing;molecular diagnostics;Morbidity - disease rate;mortality;Mucous Membrane;Natural History;next generation sequencing;Non-Hodgkin's Lymphoma;operation;Operations Research;Outcome;Pathology;penile microbiota;penis;Persons;Physicians;Pilot Projects;Population;population based;Prevalence;Principal Investigator;programs;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Rwanda;Scientist;Specimen Handling;success;sustainable resource;Teaching Hospitals;Training;Translational Research;United States;Universities;University Hospitals;vaccine effectiveness;Vertical Disease Transmission;Viral;Viral Load result;virus related cancer;Woman;Women's mortality;young woman

PROJECT_TITLE: Einstein/Rwanda/DRC Consortium for Research in HIV/HPV/Malignancies


NIH_SPENDING_CATS: Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Genetics;Nutrition;Pediatric;Prevention

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Our long-term goal is to identify mechanisms for initiation of food allergy by exposures of skin with barrier mutations and to identify factors for detection of risk for skin sensitization. As a step towards our long-term goal, our central HYPOTHESIS is that, early in life, initiation of food allergy by skin exposure to allergen is mediated by signals from keratinocytes with skin barrier mutations that induce a network of cell signals in the skin for activation of the immune system to generate allergen-specific IgE. These mechanistic studies will have a sustained impact in providing a basis towards designing interventions and clinical studies to modify food allergy initiation early in life.

PI_NAMEs: COOK-MILLS, JOAN M (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: 2 year old;3-Dimensional;Affect;Age Months;Allergens;Allergic;Allergy to peanuts;Alternaria;Anaphylaxis;blocking factor;chicken egg;Child;Clinical;Clinical Research;Consumption;Data;Defect;Detection;Detergents;Development;Dose;Dust;early onset;Eczema;environmental allergen;Exclusion;Exposure to;Food;food allergen;food antigen;food consumption;Food Hypersensitivity;Foundations;Gene Mutation;Genes;Goals;Heterozygote;high risk;Home;Human;IgE;immune activation;Immune system;Immunotherapy;In Vitro;Induced Mutation;Infant;innovation;Intervention Studies;keratinocyte;Learning;Life;loss of function mutation;Mediating;Modeling;mouse model;Mus;Mutation;Neonatal;neonatal mice;neonate;novel;Oral;Ovalbumin;Pathway Analysis;Pathway interactions;Patients;Plasma;postnatal;Predisposition;pup;Pyroglyphidae;Reaction;Recommendation;response;Risk;Risk Factors;RNA;Sampling;Signal Transduction;single-cell RNA sequencing;Skin;skin barrier;skin hypersensitivity;Tail;Testing;therapy design;transcriptome sequencing;Visual

PROJECT_TITLE: Mechanisms for initiation of food allergy early in life

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


NIH_SPENDING_CATS: Cancer;HIV/AIDS;Infectious Diseases;Sexually Transmitted Infections

PHR: Effective administration and leadership form the cornerstone of effective and productive organizations. The Center research and capacity building success requires an effective Administrative Core, so that the high-value research in HPV malignancies can be conducted and shared, and laboratory infrastructure can be effectively developed and optimally utilized. Developing local capacity to lead the Center is critical to research independence in Africa, and to the success of our Research projects and Cores.

PI_NAMEs: ANASTOS, KATHRYN M. (contact)

PROJECT_TERMS: Administrative Efficiency;Administrator;Advisory Committees;Africa;AIDS related cancer;Collaborations;college;Communities;Competence;Congo;Country;Democratic Republic of the Congo;Development;Ensure;Environment;equipment acquisition;Equipment and Supplies;flexibility;Funding;Funding Opportunities;Future;Goals;Grant;Growth;Health;Health Policy;Health Priorities;HIV;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human Resources;Infrastructure;Institution;International;Laboratories;Leadership;Malignant Neoplasms;Medicine;meetings;member;Military Hospitals;Monitor;Occupational activity of managing finances;operation;Organizational Productivity;Outcome Measure;process optimization;Productivity;Protocols documentation;Research;Research Activity;Research Project Grants;Resource Sharing;Rwanda;Services;Strategic Planning;Structure;success;symposium;System;Testing;Training;Training Activity;Travel;United States National Institutes of Health;Universities;Vision


NIH_SPENDING_CATS: Cancer;Cervical Cancer;HIV/AIDS;Infectious Diseases;Microbiome;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

PHR: PROJECT NARRATIVE Sub-Saharan Africa carries a disproportionate burden of HIV and a high burden of virally induced malignancies. Investigations of HPV-related malignancies are heavily dependent on laboratory testing and histopathology, which can be implemented in resource limited settings. The Rwanda/DRC/Einstein HIV- Associated HPV-Malignancies Research Center (HAMRC) proposed in this application will extend both the geographic and the scientific scope of our research and capacity-building activities, in part by developing a Shared Resources Core to support high risk HPV typing and next generation sequencing-based microbiome analysis.

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;aged;AIDS related cancer;anti-cancer research;Antibody titer measurement;antiretroviral therapy;Bioinformatics;Biological Assay;Cancer Etiology;Collaborations;Congo;Consent;Data;Democratic Republic of the Congo;Development;Disease;Doctor of Philosophy;Enzyme-Linked Immunosorbent Assay;Epidemic;Fostering;Funding;Funding Opportunities;Genotype;Geography;Goals;high risk population;Histopathology;HIV;HIV Infections;HPV-High Risk;Human;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;Human Resources;Immunoglobulin G;Incidence;Infection;Investigation;Kaposi Sarcoma;Laboratories;Laboratory Research;Lead;Leadership;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measurement;Measures;men who have sex with men;microbiome analysis;microbiome research;microbiota;Military Hospitals;Molecular Diagnostic Testing;molecular diagnostics;molecular pathology;next generation sequencing;Non-Hodgkin's Lymphoma;Pathology;Patients;Persons;Preventative vaccination;Protocols documentation;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;Resource-limited setting;Rwanda;Sampling;Serology;System;Teaching Hospitals;Testing;Time;tool;Translational Research;Universities;University Hospitals;Viral;Viral Load result;virus related cancer;Woman;young woman

PROJECT_TITLE: Einstein/Rwanda/DRC Consortium for Research in HIV/HPV/ Malignancies


NIH_SPENDING_CATS: Estrogen;Genetics;Kidney Disease;Women's Health Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative There is a growing consensus that men and women differ in their response to kidney injury, and their susceptibility and progression to chronic kidney disease. We will combine powerful single cell technologies with genetic studies to determine how distinct male and female cell types are generated in the mouse kidney and how these are modified during reproduction. Comparative analysis on human kidney datasets will identify shared, and species-specific, sex programs in the male and female kidney.

PI_NAMEs: MCMAHON, ANDREW P. (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Adopted;Adult;Anatomy;Androgens;Animal Model;Atlases;Attention;Biological Models;Biopsy;Body System;cell type;Cells;Chemicals;Chronic Kidney Failure;Clinical Data;Clinical Research;cohort;Communities;comparative;complex data;Consensus;Data;Data Analyses;data integration;Data Set;Discipline of Nursing;Environment;Estrogens;Estrus;Evolution;Excision;Female;Gene Expression;Genes;Genetic;genetic approach;Genetic study;Glomerular Filtration Rate;Gonadal structure;Hepatocyte;Hormonal;Hormonal Change;hormonal signals;Hormone Receptor;Hormones;Human;human data;In Situ Hybridization;Injury to Kidney;International;Kidney;kidney biopsy;kidney cell;kidney repair;kidney surgery;Kidney Transplantation;Liver;male;Maps;Mediating;men;Modification;Molecular;Molecular Profiling;mouse model;Mus;Nephrons;Normal tissue morphology;Nuclear RNA;Organ;Outcome;Outcome Measure;Overlapping Genes;Pathologic;Pathway interactions;Physiological;Play;postnatal;Potassium;Predisposition;Pregnancy;Process;programs;Prolactin;Reproduction;Reproductive Process;Reproductive system;Research Design;response;Rodent Model;Role;sex;Sex Differences;sexual dimorphism;sexual role;Signal Transduction;single cell ATAC-seq;single cell technology;single-cell RNA sequencing;Sodium;Somatotropin;Source;Sterile coverings;System;systems research;transcriptome sequencing;United States National Institutes of Health;Weaning;Woman

PROJECT_TITLE: Sexual dimorphism in the mammalian kidney

STUDY_SECTION: KMBD

STUDY_SECTION_NAME: Kidney Molecular Biology and Genitourinary Organ Development[KMBD]


NIH_SPENDING_CATS: Cancer;HIV/AIDS;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

PHR: Project Title: Developmental Core of the Rwanda/DRC/Einstein HPV/HIV-Associated Malignancies Research Center (HHAMRC) The Developmental Core of the HHAMRC aims to develop a cadre of junior and mid-level researchers who will utilize the resources developed by the Center to catalyze research in HPV/HIV-associated malignancies in Rwanda and the Democratic Republic of Congo (DRC). The specific aims of the Developmental core are consistent with the goals of the center, and will have a significant impact on public health by building capacity of local researchers and mentoring them to become independent investigators and subsequently serve a leaders of the Center in the future. The Developmental Core will be led by African investigators who are all independently funded researchers, thus, providing the ESIs with role models who have navigated challenges similar to their own and strong examples to follow/learn from.

PI_NAMEs: ADEDIMEJI, ADEBOLA  (contact)

PROJECT_TERMS: African;AIDS related cancer;apprenticeship;biobank;career;career development;Circulation;Communication;Communities;Country;Data;Democratic Republic of the Congo;Development;Ensure;experience;Funding;Funding Agency;Future;Genomics;Goals;Grant;HIV;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Individual;innovation;Institution;interest;International;Lead;Learning;Malignant Neoplasms;member;Mentors;Methods;Mission;Modeling;Molecular;Peer Review;Persons;Pilot Projects;programs;Protocols documentation;Public Health;Published Comment;Publishing;Qualitative Research;Research;research and development;Research Personnel;Research Project Grants;Resource Sharing;Resources;role model;Rwanda;symposium;Techniques;Testing;Training;United States;Work;Writing

PROJECT_TITLE: Einstein/Rwanda/DRC Consortium for Research in HIV/HPV Malignancies