PI_NAMEs: ROSEN, STEVEN TERRY (contact)

PROJECT_TERMS: Acceleration;Administrator;Area;Award;Basic Science;Benchmarking;Cancer Center;Cancer Center Support Grant;cancer initiation;cancer research center director;Catchment Area;Cell Therapy;Charge;City of Hope Comprehensive Cancer Center;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;collaborative environment;Communication;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Computational Biology;Country;Critiques;Data Analyses;Data Collection;Decision Making;Development;Development Plans;Diabetes Mellitus;Diagnosis;Doctor of Philosophy;drug development;Ensure;Environment;equity, diversity, and inclusion;Evaluation;Event;Extramural Activities;Faculty;Feedback;first-in-human;Fostering;Funding;Future;genome resource;Goals;health equity;Individual;Informatics;innovation;Institution;Interview;Leadership;Malignant Neoplasms;mass spectrometry shared resource;meetings;member;Methodology;minority engagement;multidisciplinary;NCI Center for Cancer Research;NCI-Designated Cancer Center;operation;Operations Research;Organizational Efficiency;Outcome;outreach;Patient Care;Patients;Performance;Play;Policies;Population Research;Population Sciences;Positioning Attribute;precision medicine;prevent;Process;programs;Qualifying;Recommendation;recruit;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Role;Science;Shapes;Site Visit;Strategic Planning;Structure;symposium;Textiles;Training and Education;Training Support;Translations;tumor metabolism;Work

PROJECT_TITLE: Leadership, Planning and Evaluation

STUDY_SECTION: NCI


ADMINISTERING_IC: DE

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Chronic Pain;Dental, Oral, and Craniofacial Disease;Dietary Supplements;Neurodegenerative;Neurosciences;Nutrition;Pain Research;Peripheral Neuropathy;Prevention

ORG_CITY: SAN ANTONIO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: DENTISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE There is a critical need for novel approaches to treat pain since current available chronic pain medications are limited by incomplete efficacy, risk of substance use disorder, or other adverse effects. Insights from this project will enhance our understanding of the mechanism of how an omega-6 fatty acid diet modulates nocifensive orofacial behavior. These studies will lay the foundation in a continuum of research leading to the development of novel preventative and therapeutic strategies targeting these lipids and potential proteins in the mechanism.

PI_NAMEs: TRAM, MEILINN  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acids;Address;Adjuvant;Adult;Adverse effects;afferent nerve;Afferent Neurons;allodynia;Analgesics;Arachidonic Acids;Behavior;behavioral pharmacology;behavioral response;Biochemical;Cardiovascular Diseases;career;Cell membrane;Cellular Membrane;Chronic;chronic constriction injury;chronic pain;chronic pain management;clinical translation;Computers;cost;Data;Development;Diabetes Mellitus;Diet;dietary;Dietary intake;Dietary Intervention;Disease;Disease Management;dorsal horn;Dose;Electrophysiology (science);Essential Fatty Acids;Exhibits;experience;Filament;Foundations;Frequencies;Future;Hypersensitivity;Inflammatory;inflammatory pain;inhibitor;innovation;insight;Isoenzymes;Knowledge;Linoleic Acids;lipidomics;Lipids;Maintenance;Maxilla;Measures;mechanical behavior;mechanical stimulus;Mechanics;Mediating;Membrane;Membrane Lipids;Methods;Migraine;Modeling;Molecular;Mus;Nerve;nerve supply;neuronal excitability;Neurons;Neuropathy;Nociception;Nociceptors;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Omega-6 Fatty Acids;orofacial;Orofacial Pain;Pain;Pain Disorder;painful neuropathy;Peripheral;pharmacologic;Phenotype;Phospholipase A2;Physicians;Play;Polyunsaturated Fatty Acids;Population;Pre-Clinical Model;Preparation;Property;Proteins;Quality of life;Recommendation;Research;Risk;Risk Factors;Role;Scientist;side effect;Skin;small hairpin RNA;Spinal;Spinal Ganglia;spontaneous pain;Structure of trigeminal ganglion;Substance Use Disorder;System;Techniques;Testing;Therapeutic;Tissues;Training;translational applications;Trigeminal Neuralgia;Trigeminal System;TRP channel

PROJECT_TITLE: Effects of a High Omega-6 Diet on Orofacial Allodynia

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative The proposed research will use cutting-edge single-cell epigenomic and transcriptomic technologies to map molecular and neural mechanisms of selective brain cell vulnerabilities to tauopathies in early AD impacted brain regions. Our research meets the major goals of RFA-AG-23-028 and will facilitate the development of better early diagnostic tools and new treatment strategies for AD/ADRD.

PI_NAMEs: KOOB, MICHAEL D;REN, BING ;XU, XIANGMIN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid beta-Protein;Anatomy;ApoE knockout mouse;Apolipoprotein E;apolipoprotein E-4;ATAC-seq;Atlases;Attenuated;Axon;Behavioral;Biological;Biological Assay;Brain;brain cell;Brain Injuries;Brain region;Cell Physiology;cell type;Cells;cerebral atrophy;Chromatin;Chromium;Chromosome Mapping;computational pipelines;Computer Analysis;Data;Deposition;Development;diagnostic tool;Disease;disease-causing mutation;DNA;entorhinal cortex;Epigenetic Process;epigenomics;Fluorescent in Situ Hybridization;Gene Expression;Gene Expression Profile;gene replacement;Genetic;Genomics;Goals;Hippocampus;Human;hyperphosphorylated tau;Image;Immediate-Early Genes;Individual;insight;Institution;Joints;Knock-in;Literature;locus ceruleus structure;Maps;MAPT gene;Measures;mild traumatic brain injury;Minnesota;model development;Molecular;molecular pathology;Molecular Profiling;mouse model;Multiomic Data;multiple omics;Mus;neural circuit;Neurofibrillary Tangles;neuromechanism;neuron loss;neuronal circuitry;neuronal excitability;Neurons;neuropathology;next generation;novel;novel therapeutic intervention;Pathogenesis;Pathogenicity;Pathologic;Pathology;Phase;Phosphorylation;Physiological;Population;Predisposition;Protein Isoforms;Publishing;Research;Research Personnel;Resistance;Resolution;Resources;response;RNA;Senile Plaques;Spatial Distribution;Standardization;tau Proteins;Tauopathies;Technology;Testing;Tissue Preservation;transcriptomics;Transgenic Mice;Universities;validation studies;Work

PROJECT_TITLE: Single-cell transcriptomic and epigenomic analysis of brain cell vulnerabilities to tauopathies in early AD impacted brain regions


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative We will study how tissue type genes affect the success of transplantation for patients with life- threatening blood disorders. This information will help to lower risks through individualized treatment options for future patients.

PI_NAMEs: PETERSDORF, EFFIE W (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acute Graft Versus Host Disease;Affect;African;Alleles;Allogenic;Asian;Autoimmunity;Binding;Biology;Caucasians;Clinical;clinical care;Clinical Data;clinical decision-making;clinical practice;clinically relevant;Cyclophosphamide;Data;design;Disease-Free Survival;disorder prevention;disorder risk;Disparity;Donor Selection;Dose;Epigenetic Process;Epitopes;ethnic diversity;Ethnic Origin;Exons;Failure;Future;Genes;Goals;graft vs host disease;Haplotypes;Hematological Disease;Hematopoietic Stem Cell Transplantation;high risk;Hispanic;Histocompatibility;HLA-B Antigens;HLA-C Antigens;HLA-DQ Antigens;HLA-DR Antigens;HLA-DRB1;Homologous Transplantation;immunogenicity;improved;individualized medicine;innovation;Investigation;Knowledge;Laboratories;Life;Link;Methods;Modeling;mortality;mortality risk;Nature;novel;Outcome;Patients;Peptides;Phenotype;Population;post-transplant;preference;Procedures;Property;Publishing;Race;Recurrent disease;Regimen;Relapse;relapse risk;Research;Risk;Risk Factors;Role;Safety;Selection Criteria;Siblings;stem;Structure;success;survivorship;Tissues;tool;Translating;Transplant Recipients;Transplantation;Untranslated RNA;Variant;Work

PROJECT_TITLE: Immuno and Epigenetics of Hematopoietic Cell Transplantation

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Cells are composed of thousands of molecular assemblies – protein complexes – that both define the identity of the cell and carry out its specific functions. Specific defects in protein complex assembly and function also underlie human disease. This project, now in year 9, has profiled protein interactions at proteome-scale across several human cell lines, identifying hundreds of thousands of protein interactions, most previously unknown, providing unprecedented insight into the architecture of the human proteome. 0

PI_NAMEs: GYGI, STEVEN P (contact);HARPER, JEFFREY W;HUTTLIN, EDWARD LEO

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Affinity Chromatography;Architecture;Arizona;Atlases;Benchmarking;Binding;Biological;Biology;Cell Line;Cells;Cellular Structures;Collection;Communities;Coupled;deep learning;Defect;design;Detection;Disease;experimental study;Gene Expression;Genes;genome resource;genome-wide;HCT116 Cells;Hela Cells;Human;Human Cell Line;Human Cloning;human data;human disease;human imaging;human interactome;Individual;insight;Knowledge;Libraries;Link;Maps;Mass Spectrum Analysis;Methods;Modeling;Molecular;molecular assembly/self assembly;molecular scale;multi-scale modeling;network architecture;novel;Open Reading Frames;Organelles;Pathway Analysis;Pattern;Protein Analysis;protein complex;Protein Isoforms;protein protein interaction;protein purification;Proteins;Proteome;public database;Reporting;Resources;self assembly;Signal Transduction;Specificity;Structure;synthetic polymer Bioplex;three dimensional structure;Universities;Validation;web site

PROJECT_TITLE: Systematic Exploration of the Human Interactome IV

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer;Patient Safety

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PI_NAMEs: PAWLOWSKA, ANNA  (contact)

PROJECT_TERMS: Adherence;Amendment;Awareness;Cancer Center Support Grant;Case Report Form;City of Hope Comprehensive Cancer Center;Clinical Cancer Center;Clinical Data;Clinical Management;Clinical Nursing;Clinical Nursing Research;Clinical Protocols;Clinical Research;clinical trial protocol;Clinical Trials;Consent;Data;Data Collection;data management;data quality;Dedications;design;Development;Disease;Education;electronic data;Ensure;experience;Foundations;high standard;Infrastructure;Institution;lectures;Medidata;Modality;Monitor;NCI Center for Cancer Research;novel therapeutics;Observational Study;organizational structure;patient safety;Patients;Persons;Physician Executives;Policies;Procedures;Process;process improvement;Protocol Compliance;Protocols documentation;quality assurance;Reporting;Research;Research Personnel;Resources;Role;Safety;Series;Services;Standardization;support tools;System;technology platform;Training;Training and Education;Translational Research;Work;Writing

PROJECT_TITLE: Clinical Protocol and Data Management

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative The human voltage-gated proton channel Hv1 is an emerging drug target for a variety of diseases, including ischemic stroke, neuroinflammation, and cancer. There is an unmet need for drugs capable of modulating Hv1 activity. In this project, we seek to understand how Hv1 can be inhibited by designed compounds with the goal of developing new drugs with anti-inflammatory or anticancer properties.

PI_NAMEs: TOMBOLA, FRANCESCO  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Affect;Affinity;Alberta province;Albumins;analog;antagonist;anti-cancer;Anti-Inflammatory Agents;Antineoplastic Agents;Binding;Binding Sites;Biological Assay;Biological Process;Brain Injuries;Breast Cancer Cell;Calcium Channel;cancer cell;cancer type;cell motility;Cell Physiology;Cell Proliferation;Cells;Collaborations;Computing Methodologies;Consensus;crosslink;design;Development;dimer;Disease;Docking;Drug Targeting;Electrophysiology (science);Evaluation;extracellular;Family;Genetic;Goals;Health;HL-60 Cells;Human;Immune response;improved;infancy;inhibitor;Ion Channel Gating;Ischemic Stroke;Knock-out;Ligand Binding;Ligands;live cell imaging;loss of function;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;member;Methods;migration;Modeling;Molecular;molecular dynamics;neuroinflammation;Neuroprotective Agents;neutrophil;novel therapeutics;Nox enzyme;Organic Synthesis;Peptides;pH Homeostasis;Phagocytes;Pharmaceutical Preparations;pharmacologic;Pharmacology;Play;Potassium Channel;Preparation;Production;Proliferating;Property;Proteins;Protons;rational design;Recovery;Reporting;Respiratory Burst;response;Role;scaffold;Side;simulation;small molecule;Sodium Channel;Specificity;spinal cord and brain injury;Spinal cord injury;Structural Models;Structure;Study models;System;tool;Toxin;Transmembrane Domain;Traumatic Brain Injury;Universities;Vestibule;voltage

PROJECT_TITLE: Mechanisms of Permeation and Gating of Voltage-Sensing Domains

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: MASSARELLI, ERMINIA  (contact)

PROJECT_TERMS: anti-cancer research;authority;Biometry;Cancer Center Support Grant;cancer research center director;Catchment Area;City of Hope Comprehensive Cancer Center;Clinical Research;Clinical Trials;Comprehensive Cancer Center;Concept Review;Data;Disease;Doctor of Philosophy;Ensure;Evaluation;experience;Faculty;feasibility trial;Malignant Neoplasms;member;Minority;Minority Groups;Modality;Monitor;multidisciplinary;National Cancer Institute;operation;Patients;Process;Protocols documentation;Reporting;Research;Research Design;Research Personnel;Resources;Review Committee;Safety;Scientific Evaluation;senior faculty;System;Time;Tissues;Underrepresented Populations

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The current proposal “Characterizing the role of MSRA in pancreatic tumorigenesis” will use organoid models, chemical proteomics, and biochemical tools to elucidate fundamental aspects of redox metabolism in pancreatic cancer. We anticipate our results will establish mechanistic understanding and therapeutic inroads for methionine-based redox signaling in pancreatic cancer.

PI_NAMEs: CHIO, CHRISTINE IOK IN (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Acute;Adenosine;Amino Acids;Back;Biochemical;biochemical tools;Biological;Biological Assay;Biology;cell behavior;cell injury;cell motility;Cell Survival;Cells;Chemicals;chemoproteomics;clinically relevant;clinically significant;Collaborations;Communication;Complementary DNA;Complex;CRISPR/Cas technology;Cysteine;Data;design;Doxycycline;ectoATPase;Enzymes;extracellular;Genetic;Genomic Instability;glucose metabolism;Growth;In Vitro;in vivo;inhibitor;Invaded;Knock-in;Knock-out;KRAS oncogenesis;KRAS2 gene;macromolecule;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical center;Metabolic;Metabolic Pathway;Metabolism;Methionine;methionine sulfoxide;methionine sulfoxide reductase;migration;Mitochondria;Modeling;Molecular;mouse model;Mouse Strains;Mus;mutant;Mutate;Nature;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;Oncogenes;organoid transplantation;Organoids;Outcome;oxidation;Oxidation-Reduction;Oxidoreductase;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;pancreatic tumorigenesis;Patients;Peptides;Periodicity;pharmacologic;Post-Translational Protein Processing;Predisposition;premalignant;Presbyterian Church;Primary Neoplasm;Prognosis;Protein Biosynthesis;protein expression;Proteins;Proteomics;Pyruvate Kinase;Reactive Oxygen Species;Resistance;Respiration;Role;Signal Transduction;Site;Specimen;Structure;Sulfhydryl Compounds;Sulfur;Testing;Therapeutic;Therapeutically Targetable;Tissue Microarray;Tissues;Translations;transplant model;tumor growth;Tumor Tissue;tumorigenesis;ubiquitin isopeptidase;ubiquitin-protein ligase;wound healing

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Microbiome;Nutrition;Obesity;Pediatric

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Obesity prevalence in persons with T1D has increased, which further complicates management and risk for complications. The proposed study is relevant to public health because it helps us understand the role of the gut microbiome in disease pathophysiology in T1D youth with obesity as well as potential mechanisms to modify disease.

PI_NAMEs: ISMAIL, HEBATULLAH  (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Adjuvant Therapy;Adolescent;Adult;Affect;Age;Area;Bacteria;Beta Cell;beta diversity;Bile Acids;Bioinformatics;Budgets;C-Peptide;Child;Chronic;Clinical Trials;cohort;Complications of Diabetes Mellitus;Data;Development;diabetes risk;Diagnosis;Diagnostic;Disease;Disease Management;Dose;dysbiosis;Dyslipidemias;Enrollment;Exhibits;Fatty Acids;fecal microbiome;Feces;feeding;Functional disorder;Funding;genome sequencing;Gluconeogenesis Inhibition;Goals;gut bacteria;gut microbiome;Health;high risk;Hormone secretion;Hypoglycemia;improved;incretin hormone;Individual;Inflammation;Insulin;insulin secretion;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Link;Measures;Metabolic;metabolomics;metagenomic sequencing;Metagenomics;Metformin;microbiome;microbiome analysis;microbiome composition;Modality;Modification;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity in children;Outcome;Overweight;Pathway interactions;Peripheral;Persons;Prevalence;Probiotics;Production;Proinsulin;prospective;Public Health;Race;recruit;Research;Risk;Role;Sampling;Serum;sex;skills;stool sample;Taxonomy;Therapeutic;Thinness;Volatile Fatty Acids;whole genome;Work;Youth

PROJECT_TITLE: The Gut Microbiome in Lean and Obese Youth with Type 1 Diabetes and Novel Mechanism of Action of Metformin

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]


NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: STARK, JEREMY MICHAEL (contact)

PROJECT_TERMS: anti-cancer research;Authorization documentation;base;Biomedical Research;cancer cell;Cancer Center Support Grant;Cancer Etiology;cancer genetics;cell growth;Cell Separation;cell type;Cells;Certification;chimeric antigen receptor T cells;Cities;City of Hope Comprehensive Cancer Center;Complex;Comprehensive Cancer Center;Computer software;cost;cost effective;cost effectiveness;Cytometry;data acquisition;Detection;Education;Epigenetic Process;Equipment;exosome;experimental analysis;experimental study;extracellular;Flow Cytometry;Funding;Goals;Grant;Hour;Immune response;Immune system;improved;information gathering;instrument;instrumentation;Knowledge;Learning;member;nanoparticle;NCI Center for Cancer Research;Oncolytic;operation;particle;Population;Population Heterogeneity;professor;protein expression;Publications;Qualifying;Reagent;Research;Research Personnel;Research Support;Resource Sharing;Resources;Sampling;Services;Site;Sorting;System;Technology;theories;Therapeutic;Training;Training Support;tumor microenvironment;Viral

PROJECT_TITLE: Analytical Cytometry


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Over 70% of U.S. hospitals belong to multi-hospital networks. Proponents of hospital mergers tout the potential of hospital consolidation to improve patient outcomes and decrease costs, butevidence that hospital networks actually achieve these benefits is lacking. This project will identify specific network strategies to optimize healthcare delivery that result in improved outcomes and costs, as well as provide insight into how high-performing networks have achieved success.

PI_NAMEs: IBRAHIM, ANDREW MOUNIR (contact);NATHAN, HARI

PROGRAM_OFFICER_NAME: MILLER, DANIEL

PROJECT_TITLE: Fulfilling the Promise of Hospital Consolidation to Improve Clinical Quality and Costs

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

PI_NAMEs: SYNOLD, TIMOTHY W (contact)

PROJECT_TERMS: analytical method;Applications Grants;base;Biological Assay;Biological Markers;Biological Products;Cancer Center Support Grant;Cell Count;Cell Survival;Cell Therapy;Cells;chimeric antigen receptor natural killer cells;chimeric antigen receptor T cells;Clinical;clinical investigation;Clinical Investigator;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Complex;Consult;Consultations;Correlative Study;cytokine;Cytolysis;Data Analyses;design;Development;Drug Kinetics;Elements;Endotoxins;Environment;Enzyme-Linked Immunosorbent Assay;epidemiology study;Experimental Designs;Fostering;good laboratory practice;Grant;High Pressure Liquid Chromatography;Human Resources;Immune;Immunoassay;Individual;Inductively Coupled Plasma Mass Spectrometry;instrumentation;Investigation;Laboratory Study;Malignant Neoplasms;manufacture;manufacturing process;Manuscripts;member;Molecular;Mycoplasma;Natural Killer Cells;novel;Patients;Pharmacodynamics;Pharmacology;Pharmacology Shared Resource;Phase I Clinical Trials;Population;Positioning Attribute;Practice Guidelines;pre-clinical;Preclinical Drug Development;Preparation;primary endpoint;Process;Production;programs;Protocols documentation;Publications;Qualifying;Quality Control;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Sampling;Scientist;Serum;Services;small molecule;Specimen;Specimen Handling;Testing;Training;tumor;United States National Institutes of Health;Validation;Writing

PROJECT_TITLE: Analytical Pharmacology


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE (Public Health Relevance) Significant expense and effort by groups of scientists around the world has led to identification of regions of the human genome that are associated with the genetic risk for various forms of cardiovascular disease, including coronary artery disease. Additional research is required to understand the specific genes involved, and how they work to contribute to the disease process. Such information will allow for better risk assessment and the development of better therapeutics for these diseases.

PI_NAMEs: QUERTERMOUS, THOMAS  (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Address;Anatomy;Animals;ApoE knockout mouse;Apolipoprotein E;Aryl Hydrocarbon Receptor;Atherosclerosis;Binding;blocking factor;Blood Vessels;calcification;Cardiovascular Diseases;Cell Lineage;Cell model;cell type;Cells;Cellular Morphology;Chromosome Mapping;Complex;Coronary Arteriosclerosis;Coronary artery;Coronary heart disease;Development;Developmental Process;Disease;disorder risk;Enhancers;Epigenetic Process;Fibroblasts;Functional disorder;Gene Expression;Genes;Genetic Risk;Genetic Transcription;genome wide association study;genome-wide;Goals;Human;Human Genome;In Vitro;in vivo;Investigation;Knock-out;Knockout Mice;Lesion;Link;MADH3 gene;Maps;Medial;Mediating;Modeling;Molecular;Morphology;mouse model;Mus;novel;Osteogenesis;Pathway interactions;Phenotype;Process;programs;public health relevance;recruit;Regulation;Research;Risk Assessment;Role;Scientist;Signal Pathway;Signal Transduction;Signaling Molecule;single cell ATAC-seq;single-cell RNA sequencing;Smooth Muscle Myocytes;Subcellular Anatomy;TGFB1 gene;Therapeutic;Tissues;transcription factor;transcription factor USF;transcriptome sequencing;Vascular calcification;Vascular Diseases;Vascular Smooth Muscle;Wild Type Mouse;Work

PROJECT_TITLE: Molecular mechanisms of vascular calcification and their connection to coronary disease risk

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: There has been an explosion in understanding of the biology underlying disease and interindividual variation in drug disposition and response to pharmacotherapy. This has provided unprecedented opportunities in drug development and the individualization of therapy to treat and ultimately cure disease. The proposed program will produce diverse clinical pharmacologists that will be well-trained to lead the effort to capitalize on these great opportunities.

PI_NAMEs: BROUWER, KIM L.R. (contact);GONZALEZ, DANIEL ;WATKINS, PAUL B

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Clinical Pharmacology;post-doctoral training;Training Programs

PROJECT_TITLE: UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PALMER, JOYCELYNNE  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Advanced Malignant Neoplasm;Animal Care and Use Committees;Animals;anti-cancer research;Applications Grants;Area;Basic Science;Behavioral;Bioinformatics;Biological Assay;Biometry;Cancer Center Support Grant;cancer imaging;Cancer Model;Cancer Vaccine Related Development;Cell Therapy;City of Hope Comprehensive Cancer Center;Classification;Clinic;clinical epidemiology;Clinical Investigator;Clinical Trials;Collaborations;Comprehensive Cancer Center;Computational Biology;Consultations;Data;Data Analyses;design;Development;Disease;Dose;Education;Educational workshop;Ensure;Epidemiologist;Epidemiology;epidemiology study;experience;Experimental Designs;Experimental Genetics;experimental study;Faculty;Familiarity;Fostering;Gene Expression;Genomics;graduate school;graduate student;Grant;Hematopoietic Stem Cell Transplantation;high throughput analysis;high throughput screening;Human Genetics;Human Subject Research;IACUC;Immunology;Immunotherapy;improved;Institutional Review Boards;Laboratories;machine learning model;Malignant Neoplasms;Manuscripts;mathematical methods;mathematical model;Mathematics;member;Mentorship;Methodology;Methods;microbiome;Modality;Modeling;Monitor;novel;novel therapeutics;Observational Study;Oncology;organizational structure;Population;Population Sciences;Population Study;precision medicine;preclinical development;preclinical study;Preparation;Prevention;programs;Protocols documentation;public database;Publications;Questionnaires;Reporting;Reproducibility;Research;Research Activity;research and development;Research Personnel;Research Project Grants;Resource Sharing;Safety;scientific computing;Scientist;screening;Services;skills;small molecule;Statistical Data Interpretation;Statistical Methods;statistics;Survival Analysis;Systems Biology;Taxonomy;Testing;The Cancer Genome Atlas;Toxic effect;Toxicology;Training;Training and Education;training opportunity;Translational Research;translational study;Translations;Transplant Recipients;transplantation medicine;United States National Institutes of Health;Vaccines;virtual;Walking;Work

PROJECT_TITLE: Biostatistics & Mathematical Oncology


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PHR: NARRATIVE While recent work has identified a cathepsin K-expressing skeletal stem cell in the periosteum that specifically undergoes intramembranous ossification in vivo, we have discovered that a second cathepsin K-expressing stem cell population exits in the tendon-associated paratenon that controls tendon structure and function. Interestingly, while both stem cell populations also express the collagenolytic metalloproteinase, MT1-MMP, the molecular mechanisms that control stem cell fate in these two populations remain undefined. Herein, we outline a series of new animal models and experimental approaches to define an unexpected role for MT1-MMP – independent of cathepsin K – in defining periosteal and paratenon stem cell fate and function by controlling a novel, dual YAP/TAZ-linked mechanotransduction and TGFβRIII/ TGFβ signaling axis in vitro and in vivo.

PI_NAMEs: WEISS, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Anatomy;Animal Experiments;Animal Model;bone;Bone Marrow;carboxypeptidase C;Caspase;cathepsin K;Cell Lineage;Cell Physiology;Cells;Chondrogenesis;Collagen;Collagen Type I;Cytoskeleton;Data;design;Family;Genetic Transcription;Growth and Development function;In Vitro;in vivo;intramembranous bone formation;Ligaments;Light;Link;Matrix Metalloproteinases;mechanotransduction;Membrane;Mesenchymal;Metalloproteases;MMP14 gene;Modeling;Molecular;novel;Outcome;Pathologic;Pathway interactions;Periosteum;Phenotype;Physiologic Ossification;Physiological;Play;Population;programs;proteinase In;Proteolysis;receptor;Regulation;Reporting;Role;Route;Series;Signal Pathway;Signal Transduction;skeletal stem cell;stem;stem cell differentiation;stem cell fate;stem cell function;Stem Cell Mobilization;stem cell population;stem cells;Stromal Cells;Structure;Tendon structure;Tissues;trafficking;Transforming Growth Factor beta;Transgenic Organisms;Trauma;Work

PROJECT_TITLE: Pericellular Proteolysis and the Regulation of Bone/Tendon Stem Cell Fate

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Aging

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: A “graying of America” is projected to occur over the next several years, with the number of older adults expected to exceed the number of children in the United States in 2035, according to the Census Bureau; therefore, research to understand the pathophysiological manifestations of aging and the best way to prevent them is critical. The increase in elderly Americans will also necessitate sufficient numbers of physicians specifically trained in geriatrics to care for them. This application describes a Program for Aging Research in the Summer (PARIS), which will recruit underrepresented minority medical students from Puerto Rico to perform summer research in aging at Augusta University with a long-term goal of promoting interest in aging research and geriatrics.

PI_NAMEs: BOLLAG, WENDY B (contact);ISALES, CARLOS M.

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acute Disease;Age;age-related disease;Aging;aging mechanism;aging process;American;career;Caring;Censuses;Chronic Disease;Clinic;Clinical;Disease;Geriatrics;Geroscience;Goals;Health;Health Sciences;Housing;human old age (65+);Individual;interest;Long-Term Care for Elderly;medical schools;Medical Students;Medicine;member;Mentors;minority engagement;National Institute on Aging;Older Population;Outcome;Persons;Physicians;Population;Principal Investigator;Process;Program Description;programs;Puerto Rican;Reporting;Research;Research Methodology;Risk Factors;Scientist;statistics;Students;success;Training;Transportation;Underrepresented Minority;United States;Universities


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PI_NAMEs: WILLIAMS, JOHN CHARLES (contact)

PROJECT_TERMS: Affinity;Agreement;analytical ultracentrifugation;Antibodies;aptamer;assay development;Back;base;Basic Science;Binding;Biochemical;biophysical properties;biophysical techniques;Biophysics;Biopolymers;Calorimetry;Cancer cell line;Cancer Center Support Grant;Cells;chelation;Chemicals;Circular Dichroism;Clinical;Clinical Research;Clinical Trials;Collaborations;Complex;Computer Analysis;Computer Models;Computer software;computerized tools;Computing Methodologies;Crystallization;Custom;design;detector;Development;Digit structure;Disease;DNA;drug candidate;drug discovery;Dyes;Equipment;Exclusion;experience;experimental study;fast protein liquid chromatography;Flowers;Grant;high throughput screening;House Staffs;Human;Hybrids;Image;improved;in silico;In Vitro;in vivo;Incubators;Individual;Insecta;insight;instrument;instrumentation;Ion-Exchange Chromatography Procedure;Label;large scale production;Lead;lead candidate;Legal patent;Libraries;Licensing;Ligands;Liquid substance;macromolecule;Malignant Neoplasms;manufacture;mass spectrometer;Measures;member;Methods;milligram;Modeling;molecular dynamics;Molecular Medicine;Molecular Probes;Molecular Target;mutant;nano;nanoparticle;NMR Spectroscopy;novel therapeutics;Nucleosides;Oligonucleotides;Organic Chemistry;Outcome;payment;Peptide Synthesis;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;preclinical evaluation;Process;Production;professor;Property;Protein Dynamics;protein protein interaction;protein structure;Proteins;PTPRC gene;Publications;Qualifying;Research;Research Personnel;research study;Resource Sharing;RNA;Robot;Robotics;Roentgen Rays;S phase;Scanning;screening;self assembly;Services;simulation;Site;Small Interfering RNA;small molecule;small molecule inhibitor;Solid;Specificity;structural biology;Structure;Structure-Activity Relationship;sugar;Surface Plasmon Resonance;System;Technology;Therapeutic;Therapeutic Agents;Titrations;Training;Translating;Translational Research;United States National Institutes of Health;Validation;virtual;Visualization;Water;Work

PROJECT_TITLE: Drug Discovery Structural Biology


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: Project Narrative The landmark Institute of Medicine report, “Emerging Infections: Microbial Threats to Health in the United States," noted that roughly 60% of human diseases are caused by zoonotic pathogens. The importance of this observation is exemplified by the current SARS-CoV2 pandemic, underscoring the urgent need for understanding the biology of zoonotic pathogens, including mechanisms of persistence, evolution of virulence, and epidemiology, to predict, prevent and control emerging infections This Infectious Diseases and Microbial Immunology Post-doctoral Training Program specifically prepares a scientific workforce prepared to and capable of addressing critical knowledge gaps in zoonotic infectious diseases and antimicrobial resistance emergence.

PI_NAMEs: KAWULA, THOMAS H (contact);NJENGA, M KARIUKI

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Communicable Diseases;Immunology;microbial;post-doctoral training;Training Programs

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: DAVIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The proposed research is relevant to public health because understanding the circuit, cellular and synaptic mechanisms by which the hypothalamic circadian clock regulate arousal is ultimately expected to increase understanding of how wakefulness and associated electroencephalographic rhythms are produced and maintained. As such, the proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that may yield improved pharmacologic approaches and interventional strategies, and thereby reduce the burden of human disability. This would apply to not only sleep- and arousal-based disorders, such as hypersomnia and fatigue, but also many neuropsychiatric, neurodegenerative and neurological disorders in which arousal is often severely disrupted, including depression and Alzheimer's disease.

PI_NAMEs: FULLER, PATRICK M (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Acute;Alzheimer's Disease;Anatomy;Animals;Arousal;Attenuated;base;Behavioral;Brain;burden of illness;Cell Nucleus;cell type;Cells;circadian;circadian pacemaker;clinical development;cognitive performance;Coupled;Data;Dependence;disability;Disease;Electroencephalography;Exhibits;experience;Fatigue;Functional disorder;Galanin;Genetic Transcription;Goals;Health;Heterogeneity;Human;Hypersomnias;Hypothalamic structure;Image;improved;in vivo;Individual;innovation;Intervention;Knowledge;Link;Mammals;Maps;Medial Dorsal Nucleus;Mental Depression;Mission;Molecular;Molecular Profiling;Nervous System Disorder;neural circuit;Neurodegenerative Disorders;Neurons;neuropsychiatric disorder;novel;optogenetics;Outcome;Patients;Pharmaceutical Preparations;pharmacologic;Physiological;Physiology;Population;postsynaptic;preoptic nucleus;pressure;presynaptic;prevent;Public Health;rabies viral tracing;receptor;Regulation;Research;Role;single nucleus RNA-sequencing;Site;Sleep;Source;suprachiasmatic nucleus;Surface;Synapses;Testing;therapy development;Time;transcriptome;United States National Institutes of Health;virtual;Wakefulness;Work

PROJECT_TITLE: Regulation of arousal state by the suprachiasmatic clock


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: HORNE, DAVID A. (contact)

PROJECT_TERMS: Adenovirus Vector;Advisory Committees;AIDS-Related Lymphoma;Allogenic;Autologous;Biological;Biopolymers;Biotechnology;Budgets;Cancer Center;Cancer Center Support Grant;Cancer Patient;CAR T cell therapy;CD34 gene;Cell Culture Techniques;Cell Therapy;Cells;Chemicals;chimeric antigen receptor T cells;Cities;Clinical;clinical center;Clinical Trials;Collaborations;Colorectal Cancer;Complex;Conduct Clinical Trials;cost effective;Cyclic GMP;Dendritic Cells;Development;Dose;Effector Cell;Engineering;experimental study;first-in-human;gene therapy;Genetic;Goals;Grant;Hematopoietic stem cells;imaging agent;Immune;induced pluripotent stem cell;Infusion procedures;inhibitor;innovation;Innovative Therapy;Institution;Islet Cell;Lentivirus;Lentivirus Vector;Licensing;lymphocyte product;Malignant neoplasm of lung;Malignant Neoplasms;manufacture;manufacturing capabilities;manufacturing facility;manufacturing process;manufacturing scale-up;manufacturing systems;manufacturing technology;Melanoma;member;Mesenchymal Stem Cells;Methodology;Methods;Mission;Modality;Molecular;Molecular Target;Molecular Weight;Monoclonal Antibodies;Natural Killer Cells;nerve stem cell;NK cell therapy;Non-Hodgkin's Lymphoma;novel therapeutics;oligonucleotide therapeutics;Oligonucleotides;oncology trial;Oncolytic viruses;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;phase I trial;Poxviridae;poxvirus vectors;pre-clinical;preclinical study;Preparation;Process;Production;programmed cell death ligand 1;programs;Proliferating Cell Nuclear Antigen;Protocols documentation;Publications;quality assurance;Quality Control;Regenerative Medicine;Regulatory T-Lymphocyte;Research Personnel;Resource Sharing;Resources;Retroviral Vector;Retroviridae;RNA;Services;Side;Simplexvirus;Small Interfering RNA;small molecule;small molecule inhibitor;small molecule therapeutics;Solid Neoplasm;STAT3 gene;stem cells;Suspension Culture;Suspensions;targeted agent;Testing;Therapeutic;Therapeutic Agents;therapy development;Translating;Translations;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health;Vaccines;Viral Vaccines;Viral Vector;Virus

PROJECT_TITLE: GMP Manufacturing


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: This project will investigate the molecular mechanisms by which a highly ethologically relevant and common form of stress, social defeat stress, leads to escalated alcohol consumption. Identification of such mechanisms could lead to treatments that blunt the deleterious effects of social stress.

PI_NAMEs: MAIYA, RAJANI  (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: addiction;Addictive Behavior;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohols;Animals;Anxiety;Arousal;Behavioral;behavioral response;Brain region;Candidate Disease Gene;candidate identification;cell type;Cells;Code;Databases;differential expression;dimension reduction;Disease;drinking;Drug Addiction;drug candidate;drug of abuse;Drug usage;druggable target;Enterobacteria phage P1 Cre recombinase;Estrogen Receptors;experience;experimental study;Exposure to;Female;FOS gene;Future;Gene Expression Profile;gene network;Genes;Genetic;Genetic Recombination;Genetic Transcription;Grant;high reward;high risk;Human;Human Development;Hypothalamic structure;In Situ Hybridization;Individual;inducible Cre;Knowledge;Label;Lead;Libraries;male;Maps;Mediating;Mental Depression;Mental disorders;Messenger RNA;Modeling;Molecular;Molecular Profiling;motivated behavior;Motivation;mouse model;Mus;neural;neural circuit;neuroadaptation;neuromechanism;Neurons;neuropsychiatry;Neurosecretory Systems;paraventricular nucleus;Pathway Analysis;Pathway interactions;Population;preference;prevent;Process;programs;promoter;Reporter;Resolution;response;Reverse Transcription;Rewards;Risk Factors;RNA;Rodent;Role;Signal Transduction;single nucleus RNA-sequencing;social;social defeat;Social Environment;Social Interaction;social stress;social stressor;Source;Stress;Stressful Event;stressor;Structure of paraventricular nucleus of thalamus;System;Testing;Thalamic structure;Tissue-Specific Gene Expression;transcriptome;transcriptomic profiling

PROJECT_TITLE: Molecular Signatures of Social Stress-Induced Escalation of Drinking

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Pain Research;Telehealth

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

PHR: This research is relevant to public health and NIH’s mission because it aims to test a highly accessible mobile app behavioral pain intervention (PainPac) compared to a standard therapist led videoconferencing protocol (PCST-Video) for cancer patients with pain. Behavioral pain interventions are not currently widely available to cancer patients. If PainPac is found to be feasible and beneficial for helping cancer patients learn to manage their pain, the mobile app is poised to be widely disseminated ultimately decreasing pain and suffering for patients with cancer.

PI_NAMEs: KELLEHER, SARAH  (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Adherence;Aftercare;Appointment;Appointments and Schedules;Behavior Therapy;Behavioral;Businesses;cancer care;cancer pain;Cancer Pain Management;Cancer Patient;Cellular Phone;Clinical Oncology;clinical pain;clinical practice;Cognitive;Cognitive Therapy;comparison intervention;coping;Coping Skills;cost;daily pain;Data;design;disability;Distress;effectiveness clinical trial;effectiveness testing;efficacious intervention;Electronic Mail;Electronics;Emotional;experience;flexibility;Funding;Future;Goals;Home;Hour;implementation strategy;improved;innovation;Intervention;Learning;Link;Malignant Neoplasms;Medical center;Medical Records;Mission;mobile application;mobile computing;Modeling;Nonpharmacologic Therapy;Oncology;Outcome;Outpatients;Pain;Pain interference;Pain management;Pain Measurement;pain outcome;Participant;Patient Preferences;Patients;Persons;programs;Protocols documentation;Provider;Public Health;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Relaxation;Reporting;Research;Resource-limited setting;Resources;satisfaction;Self Efficacy;Severities;Specialist;Symptoms;System;Tablets;Technology;technology intervention;Testing;Text;theories;Time;Training;Translating;United States National Institutes of Health;Update;videoconference;Videoconferencing;Work

PROJECT_TITLE: Initial Testing of a Mobile App Pain Coping Intervention for Outpatient Oncology Settings


PI_NAMEs: WU, XIWEI  (contact)

PROJECT_TERMS: Algorithms;analysis pipeline;analytical method;assay development;Bioinformatics;Biological Assay;Biological Sciences;Biometry;bisulfite sequencing;Cancer Center Support Grant;ChIP-seq;Chromium;Clinical Trials;Complex;Computational Biology;Consultations;controlled release;Copy Number Polymorphism;cost effective;Custom;Data;Data Analyses;Data Collection;data sharing;Data Sources;data submission;Dedications;design;Dideoxy Chain Termination DNA Sequencing;DNA;DNA analysis;DNA Methylation;DNA sequencing;Epigenetic Process;experience;Experimental Designs;Faculty;Generations;Genes;Genetic;Genome;genome-wide;genomic data;Genomics;Genomics Shared Resource;Genotype;Goals;Grant;High-Throughput Nucleotide Sequencing;improved;innovation;instrument;instrumentation;Length;Libraries;Liquid substance;Manuscripts;Medicine;member;Methylation;miRNA expression profiling;Mission;mRNA sequencing;multiple omics;novel;open source tool;Preparation;Protein Isoforms;Proteins;Protocols documentation;Publications;Quality Control;Reproducibility;Research Personnel;Research Project Grants;Resource Sharing;Ribosomal RNA;Ribosomes;RNA;RNA analysis;RNA immunoprecipitation sequencing;Sampling;Scientist;Services;single cell analysis;single cell genomics;single cell sequencing;single-cell RNA sequencing;Small RNA;SNP array;Source;System;Technology;Time;tool;Training;Training and Education;Transcript;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Validation;Variant;Visualization;whole genome;Work

PROJECT_TITLE: Integrative Genomics


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative We will develop deep learning-based models to predict the TCR binding specificity of neoantigens/MHC complexes (immunogenicity). We will predict patient response to checkpoint inhibitors and other forms of immunotherapy based on immunogenicity and other properties of neoantigens. We will build a comprehensive neoantigen webserver, which will facilitate a coordinated effort to accelerate tumor immunogenomics research and clinical applications for personalized medicine.

PI_NAMEs: WANG, TAO  (contact);WANG, XINLEI

PROJECT_TERMS: Acceleration;Address;analysis pipeline;antigen binding;Antigens;Benchmarking;Biological Assay;Biological Markers;Biological Process;cancer care;cancer immunotherapy;Clinical;clinical application;Clinical Data;clinical practice;cloud based;cohort;Communities;Complex;computing resources;COVID-19;Data;Data Set;data sharing;data sharing networks;Databases;deep learning;deep learning model;Disease;empowerment;enzyme linked immunospot assay;exome sequencing;experience;Extramural Activities;Feedback;Genomics;Goals;Health Insurance Portability and Accountability Act;Immune;Immune checkpoint inhibitor;Immune response;immunogenic;immunogenicity;Immunogenomics;Immunologics;Immunology;Immunotherapy;improved;Institutional Review Boards;Knowledge;Laboratories;laboratory experiment;Learning;learning algorithm;Link;Malignant Neoplasms;Methodology;Methods;Modeling;Mutation;neglect;neoantigen vaccine;neoantigens;neoplastic cell;Patient Care;patient response;Patient-Focused Outcomes;Patients;Performance;personalized medicine;phenotypic data;Play;Policies;predicting response;Prediction of Response to Therapy;predictive modeling;Process;Property;Publications;receptor binding;Records;Regulation;Reporting;Reproducibility;Research;Research Personnel;Resistance;Resources;response;Science;Services;Source;Specificity;Standardization;statistics;T cell response;T-Cell Receptor;T-Lymphocyte;transcriptome sequencing;transfer learning;treatment response;tumor;vaccine development;Validation;web portal;web server;Work

PROJECT_TITLE: Applying deep learning to predict T cell receptor binding specificity of neoantigens and response to checkpoint inhibitors

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ORG_NAME: ALLEN INSTITUTE

PHR: Project Narrative The breakdown of naïve T cell homeostasis is closely associated with increased susceptibility to infection during aging. However, very few strategies exist to study the mechanisms of long-term T cell maintenance in humans and particularly with age. The goal of this project is to utilize new single cell technologies to elucidate naïve T cell complexity and to develop novel methodologies to study age-related homeostatic decline, which will ultimately enhance immune protection against infections in older individuals.

PI_NAMEs: GUSTAFSON, CLAIRE  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Acceleration;Adenosine;Age;age effect;age related;aged;Aging;aging population;analysis pipeline;Antigens;Area;ATAC-seq;Biological Assay;Biological Models;Biomedical Engineering;career development;Cell Aging;Cell Compartmentation;Cell Differentiation process;Cell Maintenance;Cell Physiology;Cell Survival;Cells;Cellular biology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;cytokine;Cytometry;Data;Data Set;Development;Development Plans;Encapsulated;Environment;Epigenetic Process;Flow Cytometry;Functional disorder;functional loss;Genetic Transcription;Goals;healthspan;Heterogeneity;Homeostasis;Human;humanized mouse;IL7 gene;Immune;immune function;Immune response;Immunity;improved;In Vitro;in vitro Assay;Incidence;Infection;innovation;insight;Intervention;Knowledge;Light;Link;Longitudinal Studies;Lymphoid;Lymphoid Tissue;Maintenance;Mediating;Mediator;Memory;Mentors;Mentorship;Methodology;middle age;mortality;mouse model;novel;Older Population;Organoids;Pathogenicity;Pathway interactions;peripheral blood;Phenotype;Play;Population;Population Heterogeneity;Predisposition;prevent;Production;Property;Prostaglandins;Reproducibility;Research;research and development;Research Personnel;Resources;Reticular Cell;RNA;Role;Signal Transduction;single cell technology;stem;Stromal Cells;System;T-Lymphocyte;Techniques;Therapeutic Intervention;Time;Tissues;Universities;Work

PROJECT_TITLE: Dysregulation of Naïve T cell Quiescence during Aging

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Biological Aging Study Section[NIA-B]


NIH_SPENDING_CATS: Biotechnology;Cancer;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PIRROTTE, PATRICK  (contact)

PROJECT_TERMS: Acceleration;Address;Adherence;Advisory Committees;Alternative Splicing;Analytical Chemistry;analytical method;Bioinformatics;Biological Assay;biomarker validation;Biometry;Cancer Biology;Cancer Center Support Grant;Cancer Model;Cellular biology;City of Hope Comprehensive Cancer Center;Classification;Clinical;Collaborations;Collection;Communities;Comprehensive Cancer Center;Computer software;Consult;Consultations;cost effective;Cyclic GMP;dashboard;Data;data acquisition;Data Analyses;data harmonization;data integration;data quality;Data Reporting;data repository;Data Set;Databases;Dedications;design;Documentation;drug development;Education;Educational workshop;Ensure;Event;Experimental Designs;Exposure to;Faculty;Grant;Guidelines;high dimensionality;Immunooncology;Immunoprecipitation;Individual;Industry Standard;Information Dissemination;insight;instrument;instrumentation;Knowledge;Leadership;Licensing;lipidomics;Malignant Neoplasms;Manuscripts;Maps;mass spectrometry shared resource;Mass Spectrum Analysis;Mathematics;Measurement;Measures;member;metabolomics;Methods;Mission;Molecular Biology;Monitor;Multiomic Data;multiple omics;multiple reaction monitoring;Mutate;novel;Nucleotides;Oligonucleotides;Oncology;Pathway Analysis;Pathway interactions;Patients;peptide drug;Peptides;Pharmacologic Substance;Phosphoproteins;phosphoproteomics;Phosphorylation Site;Post Translational Modification Analysis;Preparation;Probability;Process;Production;protein protein interaction;Proteins;proteogenomics;Proteomics;Publications;Publishing;quality assurance;Quality Control;random forest;Reporting;Research Institute;Research Personnel;Resource Sharing;Resources;Sampling;Science;Secure;Services;Signal Transduction;Site;small molecule;Solid Neoplasm;sound;Standardization;Structure;support vector machine;SWI/SNF Family Complex;System;Testing;therapeutic target;Time;Training;transcriptomics;tumor;tumor metabolism;United States National Institutes of Health;Validation;Variant;web portal

PROJECT_TITLE: Integrated Mass Spectrometry


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: CLEMSON

ORG_DEPT: BIOLOGY

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project Narrative The roles of specific cell types in complex in vivo biological processes, such as inflammation, are difficult to disentangle. The proposed research focuses on differentiating the requirement for specific signaling pathways in macrophage versus neutrophil function. The goal of this project is to identify specific receptors and effector mechanisms that could be targeted to inhibit the function of single cell types during human disease, in place of broadly immunosuppressive treatments that cause susceptibility to opportunistic infection or organ damage.

PI_NAMEs: ROSOWSKI, EMILY  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Aspergillus fumigatus;autoinflammatory diseases;Biological Process;C Type Lectin Receptors;Cell Death;Cell Physiology;cell type;Cells;Chemicals;common treatment;Complex;Disease;Experimental Models;Future;Genes;Genetic;Goals;Homeostasis;human disease;Immune;Immune response;Immunosuppressive Agents;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune Response;Laboratories;Lectin Receptors;Macrophage;Modeling;neutrophil;Opportunistic Infections;Organ;pathogen;pathogenic fungus;Pathway interactions;Precision therapeutics;Predisposition;programs;receptor;Research;response;Role;side effect;Signal Pathway;Signal Transduction;Sterility;System;Tissues;Toll-Like Receptor Pathway;tool;Zebrafish

PROJECT_TITLE: Deciphering macrophage versus neutrophil signaling and effector functions in immune responses in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Rare genetic diseases are collectively a common cause of morbidity in children. Precision clinical management is often hindered by the difficulties in making an accurate and precise diagnosis, even with new DNA sequencing technologies that can scan all genes or even all genetic material (the `genome') at once. Here, we will extend our widely used diagnostic tool Exomiser to meet current challenges and opportunities in pediatrics by adding algorithms for new genomic technologies, analyzing molecular pathways involved in intellectual disability, and providing approaches to analyze groups of unsolved cases to identify novel disease genes.

PI_NAMEs: MUNGALL, CHRISTOPHER J;ROBINSON, PETER NICHOLAS (contact);SMEDLEY, DAMIAN

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Address;Affect;Algorithms;Animal Model;Area;Birth;Case Study;causal variant;Child;Child Care;Childhood;Clinic;Clinical;Clinical assessments;clinical care;Clinical Data;clinical decision-making;clinical diagnostics;Clinical Management;clinical phenotype;Clinical Research;cohort;Cohort Analysis;Collection;Complex;Computational algorithm;Computer Analysis;Computer software;cost;Couples;Data;Databases;Diagnosis;Diagnostic;diagnostic tool;diagnostic value;Disease;disease diagnostic;DNA;DNA sequencing;England;Evaluation;exome;exome sequencing;Finding by Cause;Frustration;gene discovery;Gene Expression;Gene Mutation;Genes;Genetic;Genetic Diseases;genetic disorder diagnosis;Genetic Materials;Genetically Modified Animals;Genome;genome sequencing;genomic data;Genomic medicine;Genomics;Health;Human;human disease;Human Genetics;improved;Individual;Intellectual functioning disability;Knowledge;Laboratories;Literature;Medical;Medicine;Mendelian disorder;meter;Methods;Modeling;Molecular;Morbidity - disease rate;new technology;next generation sequencing;novel;novel strategies;Ontology;Pathogenesis;Pathogenicity;Pathway interactions;Patients;pediatrician;Pediatrics;Performance;personalized management;phenomics;Phenotype;Population;Predictive Value;Process;Publishing;Rare Diseases;rare genetic disorder;Records;Research;Resources;RNA;RNA analysis;RNA Splicing;Role;Running;Scanning;Series;Specialist;Spliced Genes;support tools;Symptoms;Techniques;Technology;Testing;Time;Tissue-Specific Gene Expression;tool;transcriptome sequencing;United States National Institutes of Health;uptake;Variant;Visit;whole genome

PROJECT_TITLE: Increasing the Yield and Utility of Pediatric Genomic Medicine with Exomiser


PI_NAMEs: ARMSTRONG, BRIAN  (contact)

PROJECT_TERMS: Ablation;Animals;Antibodies;Applications Grants;base;Cancer Center Support Grant;Carbon Dioxide;Cells;Collection;Computer software;confocal imaging;Data;Data Set;detector;digital imaging;Ethics;experience;experimental study;Faculty;Fluorescence;fluorophore;Grant;Hypoxia;Image;Image Analysis;imaging capabilities;imaging modality;Instruction;instrument;intravital imaging;Lasers;Light;light microscopy;Lighting;live cell imaging;Mass Spectrum Analysis;member;Metals;Methods;Microscope;microscopic imaging;Mission;Modeling;Mus;next generation sequencing;Noise;Outcome;Phase;Postdoctoral Fellow;Preparation;Principal Investigator;programs;Protocols documentation;Publications;Rattus;Recommendation;Research;Research Personnel;Resolution;Resource Sharing;Safety;Sampling;Services;Signal Transduction;Slide;Structure;Students;superresolution imaging;System;Techniques;Technology;Temperature;Tissue Sample;Tissues;tool;Training;two-photon;ultra high resolution;United States National Institutes of Health

PROJECT_TITLE: Light Microscopy Digital Imaging


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Substance Misuse

ORG_CITY: TAMPA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE  This project will investigate alcohol metabolism in the liver and how alcohol metabolites can be used to modify protein structure (through a modification called acetylation). We will specifically investigate acetylation changes of histone proteins, which play an important role in gene transcription, and how the enzyme ACSS2 is involved in this process. The results of this project will provide novel insight into the link between alcohol metabolism in the liver and subsequent liver injury after long-term, excessive alcohol use.

PI_NAMEs: BURKHARDT, BRANT ROGER;STEVENS, STANLEY M (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Acetates;Acetyl Coenzyme A;Acetylation;Acute;Alcohol consumption;alcohol effect;alcohol exposure;alcohol misuse;Alcoholic Liver Diseases;Alcohols;Animal Model;Area;Biological;Cell Culture Techniques;Cell Nucleus;Cell Physiology;Cessation of life;Chromatin;chromatin immunoprecipitation;Chronic;chronic alcohol ingestion;chronic liver disease;Code;Data;Development;Enzymes;Epigenetic Process;epigenome;Ethanol;Ethanol Metabolism;fascinate;Fatty Liver;FDA approved;Foundations;Future;Gene Deletion;Genes;Genetic;Genetic Transcription;Health;Hepatic;Hepatocyte;High Fat Diet;Histone Acetylation;histone acetyltransferase;Histone H3;histone modification;Histones;Human;in vivo;Inflammation;insight;Knockout Mice;Label;Link;lipid biosynthesis;lipid metabolism;Liver;Liver diseases;liver injury;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;Modeling;Modification;mouse model;National Institute on Alcohol Abuse and Alcoholism;next generation sequencing;novel;Outcome;Oxidative Stress;Pathogenesis;Pathway interactions;pharmacologic;Phenotype;Play;Process;promoter;Promoter Regions;protein structure;Proteins;Proteome;Regulation;Research;Resolution;Risk Factors;Role;Signal Transduction;SIRT1 gene;Site;stable isotope;Testing;Therapeutic Intervention;therapeutic target;Transcription Process;Validation

PROJECT_TITLE: In vivo tracing of hepatic ethanol metabolism to histone acetylation: role of ACSS2 in alcohol-induced liver injury

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SEEWALDT, VICTORIA L. (contact)

PROJECT_TERMS: Admixture;Advisory Committees;African;analytical tool;ancestry analysis;Applications Grants;Artificial Intelligence;Asia;Behavior Therapy;Behavioral trial;Biological Assay;Biometry;built environment;Cancer Center Support Grant;cancer risk;Catchment Area;Cherokee Indian;Clinical;cloud based;cohort;Communication;Commuting;Complex;Consultations;cost effective;Crime;Data;design;Development;Devices;Early Diagnosis;Ensure;Environmental Exposure;Epidemiology;Epigenetic Process;Evaluation;Exercise;exercise intensity;Experimental Designs;Funding;gene environment interaction;Genetic;genetic epidemiology;Grant;Green space;Head;Health Disparities Research;Image;Immersion;Indigenous;Individual;Information Services;Information Technology;Intervention;Leadership;Los Angeles;Mathematics;Measures;member;Movement;multidisciplinary;multimodal data;Mutation;Neighborhoods;Oils;Oncology;Pathology;Persons;Pollution;Population;Prevention;programs;Publications;Research;Research Personnel;Resolution;Resource Sharing;response;Risk Assessment;Running;Science;Services;Side;success;Surveys;survivorship;symposium;synergism;Technology;Telemedicine;Time;Tissues;tool;Training;Translations;Tribes;Underrepresented Populations;United States National Institutes of Health;walkability;Walking;wearable device;whole slide imaging

PROJECT_TITLE: Population Facing Research


NIH_SPENDING_CATS: Asthma;Biomedical Imaging;Clinical Research;Genetics;Lung;Nutrition;Obesity;Physical Activity

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative: More than 40% of adult Americans are obese and obesity is common among patients with severe asthma. The objective of this project is to characterize airway physiology and pathology in obese asthma patients to explore the mechanisms by which obesity causes airway disease. In this way we will provide data to help inform novel treatment approaches for these patients.

PI_NAMEs: FAHY, JOHN V (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Acceleration;Address;Adrenal Cortex Hormones;Adult;Air;Airway Disease;airway epithelium;airway inflammation;airway obstruction;airway remodeling;American;Area;Asthma;asthmatic patient;Basement membrane;Biopsy;Biopsy Specimen;Body mass index;Body measure procedure;Cardiopulmonary;Cell Culture Techniques;Cells;cohort;cytokine;Data;Disease;eosinophil;Epithelial Cells;Epithelium;Exercise;exercise intolerance;Exercise Test;Exercise Tolerance;Fibroblasts;Fibrosis;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;genetic signature;Goals;Image;In Vitro;Inflammation;Inflammatory;Inhalation;Inspiratory Capacity;Insulin;Insulin Resistance;Interleukin-6;Interleukins;Knowledge;Lung;Lung CAT Scan;lung imaging;Maps;Measures;Mediating;Metabolic;Metabolic dysfunction;Methods;neutrophil;novel;obese patients;Obesity;obesity-associated asthma;Participant;Pathology;Pathway interactions;Patients;Physiological;Physiology;programs;pulmonary function;Pulmonary function tests;radiological imaging;Research;Resistance;Sampling;Sputum;Subgroup;Testing;Thick;Time;Tissue Banks;transcriptome sequencing;transcriptomics;Work;X-Ray Computed Tomography

PROJECT_TITLE: Evaluating the Impact of Metabolic Dysfunction on Asthma Pathology and Physiology

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: ASHLAND

ORG_NAME: BIOSURFACES

PHR: This revised Direct Phase II SBIR research project will improve the lives of people by providing researchers with novel and more physiologically-relevant tools and methods for in vitro testing. These tools will be used for testing potential toxicity of drugs and chemicals as well as for developing therapeutic drugs. This research project will use advanced products and methods to produce in vitro human tissue models of human respiratory and skin tissues. These products and tissue models will be utilized by researchers to test consumer products, cosmetics and chemicals for potential toxicity to the skin, and for testing chemicals and products such as tobacco smoke for potential toxicity to respiratory tissues.

PI_NAMEs: HAYDEN, PATRICK J (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: 3-Dimensional;Animal Testing;Animals;Appearance;Biological Assay;Blood - brain barrier anatomy;bronchial epithelium;Cell Culture Techniques;Cells;Chemicals;Coculture Techniques;commercialization;Complex;consumer product;Contracts;Cosmetics;Dermal;Development;Drug toxicity;efficacy testing;Electrospinning;Epithelial Cells;Extracellular Matrix;Fibroblasts;Film;Funding;Goals;Government;high throughput screening;Human;human model;human tissue;improved;In Vitro;in vitro Model;in vitro testing;in vivo;Individual;Industry;Intestines;keratinocyte;Kidney;Laboratories;Letters;Lung;Manufacturer;manufacturing process;Marketing;Membrane;Methodology;Methods;Modeling;Morphology;National Center for Advancing Translational Sciences;novel;novel strategies;open source;Penetration;Persons;Pharmaceutical Preparations;Phase;Phototoxicity;Physiological;Porosity;Production;protocol development;Protocols documentation;Qualifying;Recovery;Reproducibility;Reproduction;Research;Research Contracts;Research Personnel;Research Project Grants;respiratory;response;scaffold;screening;Skin;skin irritation;Skin Tissue;Small Business Innovation Research Grant;Technology;Testing;Therapeutic;Thick;tissue culture;Tissue Model;tissue support frame;Tissues;tobacco products;Tobacco smoke;tool;Toxic effect;Toxicology;two-dimensional;Validation;Work

PROJECT_TITLE: Development of Cell Culture Inserts and 3D In Vitro Tissue Models Utilizing Novel Electrospun Scaffolds


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Microbiome

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PI_NAMEs: HAMILTON, STANLEY R. (contact)

PROJECT_TERMS: Area;Authorization documentation;biobank;Biological Assay;Blood;Blood donor;Bone Marrow Aspiration;Bone Marrow Transplantation;California;Cancer Center Support Grant;Catchment Area;Categories;CD19 gene;CD3 Antigens;CD34 gene;CD8B1 gene;Cell Line;Cell Separation;Cells;Chromosome Mapping;Clinical;Clinical Research;Clinical Trials;cohort;Collection;Complementary DNA;Computer software;Consent;Correlative Study;cost effective;Cryopreservation;Custom;Cytogenetics;Data;Data Analyses;data lake;Development;Diagnosis;digital;digital imaging;digital pathology;Disease remission;DNA;DNA sequencing;Enrollment;Equipment and supply inventories;Feces;Fluorescent in Situ Hybridization;Frozen Sections;Gene Expression Profiling;Gene Targeting;Genomics;Genotype;Goals;Grant;Hematologic Neoplasms;Hematopathology;hematopoietic tissue;Histology;Histopathology;Human;Image Analysis;Immunohistochemistry;Immunophenotyping;In Situ Hybridization;Informatics;Institutional Review Boards;Laboratories;Libraries;Link;Liquid substance;Malignant Neoplasms;member;Mesenchymal;Microarray Analysis;microbiome;microbiome research;Molecular;Molecular Cytogenetics;molecular pathology;Monitor;Mononuclear;Mus;nano-string;NCAM1 gene;Neoplasm Circulating Cells;participant enrollment;Pathologist;Pathology;Pathology Report;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Population;precision medicine;Preparation;Process;programs;Proteins;Protocols documentation;Publications;Relapse;Research;Research Personnel;Resource Informatics;Resource Sharing;RNA;Saliva;sample collection;Sampling;Services;Shipping;single cell sequencing;Site;Skin;Slide;Solid;Solid Neoplasm;Specialist;Specimen;Spectral Karyotyping;Stains;stem;Stromal Cells;Structure;Suspensions;System;Tissue Banks;Tissue Embedding;Tissue Microarray;tissue processing;Tissue Procurements;Tissues;tumor;Tumor Tissue;Underserved Population;United States National Institutes of Health;Validation;volunteer;whole slide imaging

PROJECT_TITLE: Research Pathology


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PI_NAMEs: VALLABH, SONIA MINIKEL (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Adenine;Animal Model;Animals;Antisense Oligonucleotides;base editor;Biodistribution;Brain;Callithrix;Capsid;Clinic;clinical development;Cytosine;Data;data submission;delivery vehicle;Development;Disease;DNA Methylation;Dose;Engineering;epigenome;experience;first-in-human;gene therapy;Genetic Transcription;Goals;Head;Human;humanized mouse;Initiator Codon;Knowledge;manufacture;Modality;Modeling;Mus;Mutation;Natural History;Neurodegenerative Disorders;Patient Recruitments;pharmacodynamic biomarker;pharmacologic;Phase;Population;Primates;Prion Diseases;Prions;Production;programs;promoter;protein expression;PrP;PrP gene;Publishing;Regimen;Research Project Grants;response;risk mitigation;standard of care;targeted treatment;Terminator Codon;Testing;Therapeutic;therapeutic genome editing;Toxic effect;Toxicology;uptake;vector;Viral Vector;Work

PROJECT_TITLE: Therapeutic Editing to Lower PrP in Prion Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-G(70)R]


PROJECT_TITLE: Therapeutic editing to lower PrP in prion disease: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-G]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Brain Disorders;Emerging Infectious Diseases;Gene Therapy;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: DEVERMAN, BENJAMIN E (contact)

PROJECT_TERMS: Acceleration;adeno-associated viral vector;Adult;Area;arm;Award;base editing;Biodistribution;Biological Assay;Biology;Biotechnology;Brain Diseases;Callithrix;Capsid;Cell Culture Techniques;Cells;Central Nervous System;Collaborations;delivery vehicle;Development;Disease;DNA;Dose;Endotoxins;Engineering;epigenome editing;Formulation;Funding;Gene Delivery;gene delivery system;gene therapy;Genes;Genome;Goals;Grant;Guidelines;Hand;Human;improved;In Vitro;in vivo;inflammatory marker;Investigational New Drug Application;Knowledge;Laboratories;Lead;Leadership;Machine Learning;Mammals;manufacture;Measures;Modeling;Molecular Conformation;multidisciplinary;Mus;Mycoplasma;Neurodegenerative Disorders;nonhuman primate;novel;particle;Patients;Plasmids;Pre-Clinical Model;preclinical study;prevent;Prion Diseases;Prions;Process;Production;Proteins;PrP;PrP gene;Quality Control;Research;Resources;Role;Scientist;Technology Transfer;Testing;therapeutic genome editing;therapy design;tissue preparation;Tissues;trait;Tropism;vector;vector genome;Viral

PROJECT_TITLE: Research Core (Deverman)


PI_NAMEs: WU, ANNA M (contact)

PROJECT_TERMS: Advanced Development;Animal Experimentation;Animal Experiments;animal imaging;Animal Model;animal resource;Animals;anti-cancer research;Antibodies;Antineoplastic Agents;Basic Cancer Research;Bioluminescence;Brain;Breast;Cancer Biology;Cancer Center Support Grant;cancer immunotherapy;Cell Physiology;City of Hope Comprehensive Cancer Center;Clinic;Collaborations;Colorectal Cancer;comparative;Comprehensive Cancer Center;Computer software;Consultations;cost effective;Data;Data Analyses;Data Collection;design;Development;Diagnosis;Drug Delivery Systems;drug development;drug metabolism;Education;Ensure;Equipment;Evaluation;experimental study;Faculty;Fluorescence;Goals;Grant;Guidelines;Hazardous Substances;Hematologic Neoplasms;Hematopoietic Neoplasms;Hepatocyte;Human;Human Resources;humanized mouse;IACUC;Image;imager;Imaging Device;imaging study;Imaging technology;Immune system;Immunodeficient Mouse;Immunology;in vivo;in vivo imaging;Individual;individual patient;Infection;instrument;instrumentation;investigator training;Kidney;Label;Laboratories;leukemia;Liver;Lung;Lymphoma;Magnetic Resonance Imaging;Maintenance;Malignant Neoplasms;Medicine;member;Modeling;Molecular;Monitor;mouse model;Multimodal Imaging;NCI Center for Cancer Research;next generation;novel;operation;optical imaging;organizational structure;Pancreas;patient derived xenograft model;Peptides;Performance;PET/CT scan;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Positron;Positron-Emission Tomography;Postdoctoral Fellow;pre-clinical;precision medicine;preclinical study;Predisposition;Preparation;Procedures;professor;Prostate;Proteins;Protocols documentation;Publications;Qualifying;Radiation;Radioactive;Radioisotopes;Radionuclide Imaging;Research;research and development;Research Personnel;Research Support;Resource Sharing;Resources;response;service delivery;Services;small molecule;Solid Neoplasm;stem cell therapy;Support System;Surveys;System;Techniques;theories;theranostics;Therapeutic Agents;therapeutic development;Toxic effect;Training;Translating;translational cancer research;treatment response;tumor;tumor growth;ultrasound;United States National Institutes of Health;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Small Animal Studies


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: Los Angeles

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Birth defects and skeletal diseases affecting the skull and jaw are a major societal burden. We propose to use zebrafish, a highly regenerative vertebrate amenable to powerful genetic and imaging techniques, to understand how stem cells build and then maintain and repair the head skeleton. The long-term goal is to use foundational knowledge acquired in the zebrafish to develop new regenerative medicine treatments for human craniofacial diseases.

PI_NAMEs: CRUMP, GAGE D (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Adult;Affect;Arthritis;arthropathies;Award;bone;California;career;Cartilage;Cells;Congenital Abnormality;craniofacial;craniofacial development;craniofacial repair;craniofacial tissue;cranium;Development;Disease;Doctor of Philosophy;Economics;endogenous stem cells;Face;Faculty;Fellowship;Fishes;Funding;Future;gene editing technology;Genes;Genetic;Genetic Techniques;Goals;Head;healing;high school;Human;human model;Image;Imaging Techniques;improved;Industry;Injury;innovation;Jaw;Joints;Knowledge acquisition;Maintenance;man;member;Mentors;Microscopy;Modeling;Mus;National Institute of Dental and Craniofacial Research;Natural regeneration;notch protein;novel;Patients;Pattern;Population;Positioning Attribute;Postdoctoral Fellow;Privatization;progenitor;programs;Publishing;recruit;regenerative;regenerative approach;Regenerative Medicine;Regulation;repaired;Research;Research Personnel;Resources;Role;Science;Signal Transduction;skeletal;skeletal disorder;Skeleton;stem cell biology;Stem Cell Research;stem cells;Surgical sutures;Temporomandibular Joint;tenure track;underrepresented minority student;Universities;Work;Zebrafish

PROJECT_TITLE: Progenitor Regulation in Craniofacial Development and Regeneration


PROJECT_TITLE: Research Project 1


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Auditory-guided behavior is ubiquitous in everyday life. The deep layers of the auditory cortex gives rise to a major projection system that exerts brain-wide influence over many downstream regions, providing a putative substrate for such behavior. The proposed studies will monitor and manipulate this cortical output in awake, behaving mice, providing an important first step in understanding how corticofugal circuits govern animal behavior and insight into how descending contributions that may underlie sensory dysfunction.

PI_NAMEs: WILLIAMSON, ROSS STEWART (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Active Listening;Anatomy;Anesthesia procedures;Animal Behavior;Animals;Apical;Area;association cortex;Auditory;Auditory area;auditory categorization;auditory pathway;awake;Axon;Behavior;Behavioral;behavioral outcome;behavioral response;Brain;Brain region;Calcium;Categories;cell type;Cognitive;Corpus striatum structure;Data;Decision Making;Dendrites;design;flexibility;Functional disorder;Genetic;Goals;Head;Image;in vivo;Individual;Inherited;insight;Knowledge;Learning;Life;Mediating;Midbrain structure;Monitor;Morphology;Motor;Mus;Neocortex;neural;neural circuit;Neurons;novel;optogenetics;Output;Parietal Lobe;Pathway interactions;Physiological;Pilot Projects;Play;Population;Positioning Attribute;Process;Property;Research;response;Role;Route;Sensory;sensory cortex;sensory stimulus;Shapes;Signal Transduction;Source;Stimulus;Structure;System;Techniques;Testing;transmission process;two-photon;Viral;Work

PROJECT_TITLE: Extratelencephalic contributions to auditory categorization

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Methamphetamine;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: HIV reservoirs and meth use grant. M. Stevenson, H. Tookes, PIs. A. Carrico, L Ndhlovu Co-Is Project Narrative This project will assess whether use of meth by HIV-1 infected MSM triggers activation of viral reservoirs and whether this correlates with an increase in HIV clinical disease markers. The project will use novel molecular approaches to assess HIV reservoirs within infected MSM who use meth. This information will provide a fuller understanding of how drug use promotes clinical disease progression in the face of antiviral therapy.

PI_NAMEs: CARRICO, ADAM WAYNE;STEVENSON, MARIO  (contact);TOOKES, HANSEL EMORY

PROGRAM_OFFICER_NAME: DRGONOVA, JANA

PROJECT_TERMS: Acceleration;Address;Anti-viral Therapy;antiretroviral therapy;Binding;biobehavior;Biological Assay;CD14 gene;CD4 Positive T Lymphocytes;Cells;Cellular Assay;Clinical;clinical phenotype;cohort;Collaborations;Cross-Sectional Studies;Data;Development;Disease Marker;Disease Progression;DNA;DNA Methylation;Drug usage;Enrollment;Epigenetic Process;Evaluation;experience;follow-up;Genetic Transcription;Goals;Grant;Harm Reduction;Health;HIV;HIV Infections;HIV-1;immune activation;Immune System Diseases;Immunologic Markers;In Vitro;in vivo;Individual;Inflammation;Inflammation Process;insight;Interleukin-6;Interruption;Lymphoid;Lymphoid Cell;Macrophage;men who have sex with men;Methamphetamine;methamphetamine use;methylation pattern;microbial;minimally invasive;Modernization;Molecular;monocyte;Myelogenous;Myeloid Cell Activation;Myeloid Cells;Neuroimmune;Neuropathogenesis;neuropsychiatry;novel;Pathogenesis;Patient Self-Report;peer;Pharmaceutical Preparations;Plasma;prospective;Protocols documentation;reactivation from latency;Research Personnel;Resources;Risk;Sampling;Services;stimulant use;substance use;Surrogate Markers;therapy adherence;TNF gene;Viral;viral DNA;Viral Load result;Viral Markers;viral rebound;Viral reservoir;viral RNA;virome;Virus Activation;Vulnerable Populations

PROJECT_TITLE: Relationship between methamphetamine use, viral reservoir dynamics and clinical progression in treated HIV infection


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Emerging Infectious Diseases;Foodborne Illness;Gene Therapy;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: MINIKEL, ERIC VALLABH (contact)

PROJECT_TERMS: Adenine;Attenuated;base editing;base editor;Biodistribution;Brain;Callithrix;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Cytosine;Data;Development Plans;Dimensions;Disease;Dose;Epigenetic Process;epigenome;gain of function;gene therapy;Goals;Head;head-to-head comparison;Human;humanized mouse;improved;in vivo;Inherited;Initiator Codon;Lead;lead candidate;Learning;Modeling;Molecular Conformation;Mus;Neurodegenerative Disorders;neuropathology;Outcome;patient population;pharmacologic;Preventive treatment;Prion Diseases;Prions;programs;Protein Engineering;Proteins;PrP;PrP gene;Research;Research Project Grants;response;screening;Specificity;standard of care;symptom treatment;System;Terminal Disease;Terminator Codon;Testing;therapeutic genome editing;Time;vector;Zinc Fingers

PROJECT_TITLE: Research Project 2


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative. Better reactions lead to better drugs. This work provides a computational and experimental framework to pivot highly abundant amine and carboxylic acid building blocks from the traditional amide coupling reaction into a suite of carbon-carbon bond forming reactions that are optimized for library synthesis.

PI_NAMEs: CERNAK, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: New Amine-Acid Couplings and Their Impact on Medicinal Properties

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The majority of individuals with opioid use disorder (OUD) smoke cigarettes, and they have less success quitting smoking and higher rates of tobacco-related mortality compared to the general smoking population. Novel cigarette reduction approaches, such as substitution of electronic cigarettes (e-cigarettes) for combusted cigarettes, are urgently needed in this population. This proposal will employ a randomized waitlist-controlled trial with a mixed-methods sequential explanatory design to investigate the feasibility, acceptability, and preliminary effects of substituting e-cigarettes for cigarettes on tobacco use and exposure (e.g., cigarettes smoked per day, biomarkers, cigarette dependence) in individuals who smoke (not ready to quit smoking) receiving OUD treatment, to help inform tobacco control policy and clinical practice.

PI_NAMEs: STRECK, JOANNA  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Acceleration;Address;Adult;Adverse effects;Aerosols;Anabasine;Applications Grants;Area;Behavior;behavior change;Biological Markers;Buprenorphine;buprenorphine treatment;Carbon Monoxide;career;Categories;Cigarette;cigarette smoke;cigarette smoking;clinical practice;Clinical Trials;combustible cigarette;comorbidity;Competence;Conduct Clinical Trials;Cotinine;Cross-Sectional Studies;Data;Data Analyses;Death Rate;Decision Making;Dependence;design;Development;Devices;e-cigarette cessation;Educational process of instructing;Electronic cigarette;electronic cigarette use;Enrollment;Environmental Risk Factor;Epidemic;Evaluation;experience;Exposure to;Faculty;FDA approved;Foundations;Future;General Hospitals;General Population;Goals;Harm Reduction;Health;High Prevalence;Individual;interest;International;Intervention;Interview;K-Series Research Career Programs;Knowledge;Marketing;Massachusetts;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;mortality;Motivation;National Institute of Drug Abuse;Nicotine;non-smoker;novel;novel strategies;opioid use disorder;Outcome;Outcome Measure;Participant;patient oriented;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;pod mods;Policy Making;polysubstance use;Population;Prevalence;preventable death;primary care practice;primary outcome;prospective;psychiatric symptom;public policy on tobacco;Randomized;Randomized, Controlled Trials;recruit;reduce tobacco use;reduced substance use;Reporting;Research;Research Design;Research Methodology;Research Personnel;Respiratory Signs and Symptoms;retention rate;skills;Smoke;Smoker;Smoking;smoking cessation;smoking intervention;social;Standardization;Stimulus;substance use;success;Testing;therapy development;Tobacco;tobacco exposure;Tobacco smoke;Tobacco smoking behavior;Tobacco use;tool;Toxin;Training;Vulnerable Populations;Waiting Lists;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  Wnt signaling is a rapidly evolving and important field of investigation and new regulators involved in this cascade are continuously being identified. Our study focuses on developing a mechanistic understanding of PTPRF-mediated regulation of Wnt signaling and intestinal stem cell function. Results from our studies will help identify new therapeutic strategies for treating Wnt-driven diseases by using PTPRF as a target.

PI_NAMEs: GAO, TIANYAN  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: 3-Dimensional;Attention;Attenuated;Automobile Driving;beta catenin;Bioinformatics;Biological Process;cancer cell;Caveolins;Cell Differentiation process;Cell membrane;Cell Proliferation;Cells;Cellular biology;Colon;colon cancer patients;Colon Carcinoma;colon tumorigenesis;Colorectal Cancer;Complex;CRISPR/Cas technology;Data;Development;Disease;Endocytosis;Ensure;Epithelium;Equilibrium;Genes;Goals;Human;Human body;In Vitro;in vivo;inhibitor;insight;Internal Ribosome Entry Site;intestinal crypt;intestinal epithelium;intestinal homeostasis;Intestines;Investigation;knock-down;Knock-out;Knockout Mice;Knowledge;LGR5 gene;Maintenance;Mediating;Modeling;Molecular;Mus;Mutation;novel;novel therapeutic intervention;Oncogenic;Organism;Organoids;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Physiology;Play;Process;Proliferating;Protein Dephosphorylation;Protein Kinase;Protein phosphatase;Protein Tyrosine Phosphatase;Proteins;PTPRR gene;receptor;Regulation;Reporter;Role;Sampling;self-renewal;Signal Transduction;single-cell RNA sequencing;stem cell fate;stem cell function;stem cell proliferation;stem cells;success;System;targeted treatment;Technology;Testing;Tissues;tumor growth;ubiquitin-protein ligase;Ubiquitination;Villus;WNT Signaling Pathway

PROJECT_TITLE: Study of PTPRF-Mediated Regulation of Wnt Signaling

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


PROJECT_TITLE: Research Project 3


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Services;Networking and Information Technology R&D (NITRD);Physical Rehabilitation;Rehabilitation;Telehealth

ORG_CITY: CHICAGO

ORG_NAME: COAPT, LLC

ORG_STATE: IL

PHR: 8. PROJECT NARRATIVE This project will develop and evaluate a connected health system for upper limb myoelectric pattern recognition-controlled prostheses in which data collected from wearers during everyday prosthesis use and while using a mobile application will be stored in the cloud. The cloud-connected data will be processed using cloud computing tools and presented in a web-based data portal to provide clinicians actionable insights and suggestions for assessments and interventions. Access to objective measures of wearers’ daily prosthesis use and performance will assist clinicians in their clinical decision making towards delivering more effective therapy which will improve rehabilitation outcomes for wearers.

PI_NAMEs: WRIGHT, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Acceleration;Access to Information;Activities of Daily Living;Address;Algorithms;blind;Calibration;care outcomes;Clinic;Clinical;Clinical Assessment Tool;Clinical assessments;clinical care;clinical decision-making;clinical implementation;clinical practice;Clinical Research;Clinical Trials;clinically actionable;cloud based;Cloud Computing;cloud storage;Complement;Complex;connected health;Control Groups;Current Procedural Terminology Codes;daily functioning;dashboard;Data;data portal;Data Storage and Retrieval;design;Development;Devices;Diagnosis;digital health;disability;effective therapy;efficacy evaluation;Elbow;Electrodes;Electromyography;Evaluation;experience;Feedback;Flying body movement;Frequencies;functional improvement;functional restoration;functional status;Goals;Hand;Health Insurance Portability and Accountability Act;Health system;implementation science;improved;Individual;insight;Intervention;Interview;Intuition;Learning;Life;limb loss;Limb Prosthesis;Machine Learning;Manufacturer;Marketing;Measures;mobile application;Motion;Muscle;myoelectric control;Myoelectric prosthesis;Online Systems;Outcome;Patient Selection;Patient-Focused Outcomes;Patients;Pattern;Pattern Recognition;Performance;powered prosthesis;Process;Prosthesis;prosthesis wearer;prototype;Quality of life;Rehabilitation Outcome;Rehabilitation therapy;Reporting;Sales;satisfaction;Secure;sensor;Services;Skin;standard of care;statistics;Stream;Structure;Suggestion;Surveys;System;Techniques;Technology;Therapeutic;therapy outcome;Time;tool;Training;trend;Upper Extremity;usability;user-friendly;virtual;web app;web portal;Work;Wrist

PROJECT_TITLE: A Web-based Digital Health Portal for Practitioners to Improve Clinical Care and Patient Outcomes for Upper-limb Myoelectric Prosthesis Wearers


NIH_SPENDING_CATS: Aging;Back Pain;Chronic Pain;Clinical Research;Disability Research;Pain Research;Precision Medicine

ORG_CITY: SEATTLE

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Narrative/public health relevance Lumbar spinal stenosis is a common cause of low back pain and disability among older adults. This prospective, inception cohort study aims to develop and evaluate a clinically applicable model to reliably predict long-term function of older patients initiating non-surgical care for symptomatic lumbar spinal stenosis. This approach will enable matching these individuals to optimal treatment approaches to provide care that is more effective and of higher-value.

PI_NAMEs: RUNDELL, SEAN DANIEL (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Adult;Advisory Committees;Age;aged;Anatomy;Anxiety;Back;Back Pain;Calibration;Caring;Characteristics;Chronic;Chronic low back pain;Clinic;Clinical;clinical application;clinical decision-making;clinical phenotype;Clinical Trials;Clinical Trials Design;Cohort Studies;comorbidity;Computerized Medical Record;Data;Decision Making;Degenerative Disorder;Degenerative polyarthritis;design;Diabetes Mellitus;disability;Disabling;Effectiveness;Enrollment;expectation;functional outcomes;Future;Goals;Health;Health Policy;Healthcare;Heterogeneity;Image;improved;improved outcome;indexing;Individual;individualized medicine;Intervention;Interview;Level of Evidence;Low Back Pain;Lower Extremity;Malignant neoplasm of lung;Measures;Medicine;Mental Depression;Modeling;Modification;Neurologic Symptoms;novel therapeutic intervention;older adult;older patient;Operative Surgical Procedures;optimal treatments;Outcome;Pain;Pain Research;pain symptom;Participant;Pathway interactions;Patient Care;patient oriented;patient prognosis;Patients;Performance;personalized care;personalized medicine;Pharmaceutical Preparations;Phenotype;Physical Function;Population;predictive modeling;Prevalence;primary care setting;Prognosis;prognostic;Prognostic Factor;prognostic model;prospective;Psychological Factors;public health relevance;Questionnaires;Recommendation;recruit;Reporting;Research;Research Design;Research Personnel;Resources;Risk;Self Management;sound;Spinal Stenosis;Stenosis;Stroke;Subgroup;Symptoms;Telephone;Telephone Interviews;Testing;treatment comparison;trial design;United States;United States National Institutes of Health;Validation;Vertebral column;Visit;Walking;Work

PROJECT_TITLE: Lumbar Stenosis Prognostic Subgroups for Personalizing Care and Treatment (PROSPECTS)

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Bioengineering;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Immunotherapies have potential to provide curative treatment for patients with HNSCCs, but there is a major unmet clinical need to overcome resistance that limits the clinical response rate. We will determine the yet undetermined role of mechanical regulation of monocytes towards developing new strategies to target and re- program myeloid inflammation in HNSCCs. Therefore, these proposed studies will significantly advance fundamental and translational insights on cancer immunology and ultimately impact patient care.

PI_NAMEs: VINING, KYLE HOLMBERG (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Address;advanced disease;Animal Model;anti-PD-1;anti-PD-L1;Archives;Area;Automobile Driving;Award;Behavior;Bioinformatics;Bone Marrow;Bone Regeneration;career;Cells;Clinical;Collagen;crosslink;curative treatments;cytokine;Dana-Farber Cancer Institute;Data;Dendritic Cells;Dental;Dentists;directed differentiation;Disease;Educational workshop;Elasticity;Encapsulated;Enzymes;Exclusion;Exhibits;Extracellular Matrix;Fibrillar Collagen;Fibrosis;Gel;Genetic Transcription;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Homeostasis;Human;I-kappa B Proteins;Immature Monocyte;Immune;immune cell infiltrate;immune checkpoint blockade;immune resistance;Immunologist;Immunooncology;Immunophenotyping;Immunotherapy;improved;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;inhibitor;insight;Investigation;Knowledge;Learning;Liquid substance;malignant mouth neoplasm;Malignant Neoplasms;mechanical drive;mechanical properties;mechanical signal;Mechanics;medical schools;Mentors;Metastatic/Recurrent;Molecular;Molecular Profiling;monocyte;multidisciplinary;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Natural regeneration;Nivolumab;novel strategies;Oncologist;Oral;Outcome;Pathologic;Patient Care;patient prognosis;Patients;Periodontal Diseases;Phase;Play;Population;programs;Property;Pulpitis;Regulation;Relaxation;Reporting;Research;Resistance;response;Role;Sampling;Scientist;single-cell RNA sequencing;Solid;Solid Neoplasm;Squamous Cell;STAT3 gene;Stress;Stromal Cells;System;T-Lymphocyte;Testing;Tissues;Training;transcription factor;Treatment Efficacy;tumor;Tumor Cell Invasion;Tumor Immunity;tumor immunology;tumor progression;Tumor stage;tumor-immune system interactions;Unfavorable Clinical Outcome;Up-Regulation;viscoelasticity;Viscosity;Work

PROJECT_TITLE: Targeting mechanical regulation of monocyte fate in head and neck cancer.