ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC

PHR: PROJECT NARRATIVE During embryonic development, cells producing Sonic Hedgehog (SHH) extend long, thin filopodia called cytonemes to transport the morphogen directly to receiving tissue. Our lab has developed fixation protocols to preserve these delicate structures in cultured cells and mouse embryos for confocal imaging. My project utilizes these protocols in combination with biochemical techniques to determine the cell surface interactions that are promoting SHH-induced cytoneme formation and the intracellular signaling pathways leading to cytoskeletal rearrangement and cytoneme outgrowth.

PI_NAMEs: DALY, CHRISTINA ADELE (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Actin-Binding Protein;Actins;Address;adult stem cell;Appearance;autocrine;Automobile Driving;Binding;Biochemical;Biochemistry;bioimaging;Biological;Brothers;Cell Adhesion;Cell Communication;Cell Differentiation process;Cell surface;Cell-Adhesion Molecule Receptors;Cells;Communication;confocal imaging;Cultured Cells;Cytoskeletal Modeling;Cytoskeleton;Defect;defined contribution;Development;developmental disease;Developmental Process;Disease;Electron Microscopy;Embryo;Embryonic Development;Fibroblasts;Filopodia;Fixatives;Funding;Genetic;genetic manipulation;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;Image;imaging approach;Imaging Techniques;In Vitro;in vivo;Integral Membrane Protein;kinase inhibitor;Knowledge;Laboratories;Ligands;Limb Development;Link;malformation;Malignant - descriptor;Malignant Neoplasms;Mediating;Methods;Molecular;morphogens;Mus;Mutant Strains Mice;Neural tube;Neural Tube Development;Oncogenes;Pathology;Pathway interactions;Pattern;Phosphorylation;Phosphotransferases;Physiological;Play;polymerization;Polymers;preservation;Process;protein protein interaction;Proteins;Protocols documentation;receptor;Regulation;response;rho GTP-Binding Proteins;Role;sample fixation;SHH gene;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;smoothened signaling pathway;Sonic Hedgehog Pathway;sonic hedgehog receptor;stem cell niche;Structure;Techniques;Testing;Thinness;Tissues;Translating;tumor

PROJECT_TITLE: Molecular Mechanisms Underlying Cytoneme Formation by Sonic Hedgehog-Producing Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSURGERY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE: In this proposal we will evaluate the mechanisms through which the transcription factor Blimp1 regulates the stability of eTregs and TFR cells during EAE and MS, and how loss of Blimp1 in eTregs re-shapes the CNS and overall neuroinflammation. We will also define the contribution of TFR cells and antibody responses to the regulation of CNS autoimmunity. The information obtained from this proposal will be used to develop strategies for novel therapeutic approaches to MS and other autoimmune disorders.

PI_NAMEs: LEAVENWORTH, JIANMEI WU (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Ablation;Adopted;Affect;anergy;Animal Model;Antibodies;Antibody Affinity;Antibody Response;Antigens;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;B-Lymphocytes;Biological Assay;Biology;Cells;Central Nervous System;CNS autoimmunity;comparison control;Data;defined contribution;Deposition;Development;Disease;Disease Progression;disorder control;effector T cell;Ensure;Epigenetic Process;epigenomics;Eragrostis;Experimental Autoimmune Encephalomyelitis;FOXP3 gene;Generations;Genetic;glial activation;Glycolysis;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;IgE;IL17 gene;Immune response;Impairment;Infection;Inflammatory;Inflammatory Response;insight;Interleukin-10;Maintenance;Mediating;Metabolic;metabolic fitness;microbial;Modeling;Molecular;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelin;Nature;neuroinflammation;novel therapeutic intervention;oligodendrocyte-myelin glycoprotein;Paralysed;Pathogenesis;Phenotype;prevent;programs;Publications;Recovery;Regulation;Regulatory T-Lymphocyte;response;restraint;Role;Secondary to;Serum;Shapes;Structure of germinal center of lymph node;T-Lymphocyte Subsets;tertiary lymphoid organ;Testing;TFRC gene;Tissues;transcription factor;transcriptomics;Vaccination

PROJECT_TITLE: Contribution of the effector Treg-B-antibody nexus to the regulation of CNS autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Alzheimer’s disease will affect an estimated 14 million Americans by the year 2050, contributing to economic burden and reduced quality of life for patients and caregivers. As the U.S. population ages, it is critically important to identify who is at greatest risk for Alzheimer’s disease-associated cognitive decline. Studying novel markers of risk for and resilience to cognitive decline in cognitively normal older adults may identify those who would benefit most from early detection and treatment strategies for Alzheimer’s disease.

PI_NAMEs: KORTHAUER, LAURA  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Affect;Age;Aging;Alzheimer disease detection;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;Apolipoprotein E;Area;Atrophic;Behavior;Behavioral;biomarker performance;biomarker validation;blood oxygen level dependent;Brain;career development;Caregivers;Clinical;Clinical Research;Cognition;Cognitive;cognitive control;cognitive neuroscience;cognitive reserve;cohort;Compensation;complex data;Data;Development;Development Plans;diagnostic accuracy;Diffusion Magnetic Resonance Imaging;dimension reduction;dimensional analysis;Dorsal;Early Diagnosis;Early treatment;Economic Burden;Electroencephalography;Electrophysiology (science);executive function;experience;Family;First Degree Relative;Fostering;Functional disorder;Functional Magnetic Resonance Imaging;Goals;high risk;Impaired cognition;improved;indexing;Individual;Infrastructure;Investigation;Knowledge;laboratory experience;Magnetic Resonance Imaging;Measures;medial temporal lobe;Mediating;Memory;Mentorship;mild cognitive impairment;Monitor;network dysfunction;neural;Neuroanatomy;Neurocognitive;Neurons;Neuropsychology;novel;novel marker;older adult;Participant;Pathway interactions;Patients;Performance;Persons;Phase;Population;pre-clinical;Proxy;Public Health;Quality of life;Recording of previous events;Registries;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;resilience;Resources;Rest;Retrieval;Rhode Island;Risk;Risk Marker;risk prediction;Semantics;Signal Transduction;Statistical Methods;statistics;Synapses;tau Proteins;Technical Expertise;temporal measurement;Training;Training Activity;treatment strategy;validation studies;white matter

PROJECT_TITLE: Novel Neurocognitive Markers of Risk for and Resilience to Cognitive Decline in Preclinical Alzheimer's Disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Human Genome;Immunotherapy;Liver Cancer;Liver Disease;Nutrition;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Non-alcoholic fatty liver disease is a common and serious public health problem that currently lacks effective therapies. Secreted hormones are an important class of metabolic regulators in the body that are uniquely amenable for therapeutic development. We propose to use state-of-the-art genomic tools and genetic and disease models to investigate the mechanisms of action and therapeutic potential of a fat-derived hormone in treating metabolic liver disease.

PI_NAMEs: LIN, JIANDIE D (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Adipose tissue;Attenuated;Biological;Biology;cancer immunotherapy;CD8-Positive T-Lymphocytes;Cell Separation;cell type;Cells;cellular targeting;Chimeric Proteins;Clinical;Data;design;Development;Diet;Disease;disease model;Disease Progression;effective therapy;efficacy evaluation;Endocrine;ErbB4 gene;exhaustion;Exhibits;Fatty acid glycerol esters;Funding;gain of function;Genetic Models;genomic tools;Half-Life;Health;Hepatic;Hepatocarcinogenesis;Hepatocyte;Heterogeneity;Homeostasis;Hormonal;hormonal signals;Hormone secretion;Hormones;Human;Immune;Immune checkpoint inhibitor;Impairment;improved;insight;Insulin Resistance;Link;lipid biosynthesis;Liver;Liver diseases;liver injury;liver metabolism;loss of function;Macrophage;Malignant neoplasm of liver;Mediating;Metabolic;Molecular Profiling;mouse model;Mus;Nature;neuregulin-4;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Obesity;Organ;overexpression;Pathogenesis;Physiology;Plasma;Play;Population;preservation;Primary carcinoma of the liver cells;Property;Public Health;Recombinant Proteins;Recombinants;Regulation;Research;Resolution;Role;Shapes;Signal Transduction;single cell analysis;single-cell RNA sequencing;Stress;synergism;T-Lymphocyte;Testing;Therapeutic;therapeutic development;therapeutic target;Tissues;transcriptome;transcriptomics;Transgenic Mice;Transgenic Organisms;translational study;Treatment Efficacy;TREM2 gene;Tumor Immunity

PROJECT_TITLE: Dissecting the NRG4 hormonal checkpoint in metabolic liver disease

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Interstitial Cystitis;Neurosciences;Pain Research;Urologic Diseases;Women's Health Research

ORG_CITY: Los Angeles

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a common, chronic, and often debilitating condition. The cause of IC/BPS is not known, and there are no treatments that work well. In this project, we will test if non- invasive brain stimulation can reduce IC/BPS pain, and determine how the stimulation works to improve function in the body.

PI_NAMEs: KUTCH, JASON J. (contact);RODRIGUEZ, LARISSA

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: activity marker;Agreement;Area;Bladder;Brain;Brain region;Chronic;chronic pain;Clinical Trials;comparison group;Data;Disease remission;effective therapy;Electromyography;Esthesia;Frequencies;Functional disorder;functional improvement;Functional Magnetic Resonance Imaging;Future;Goals;imaging study;improved;Individual;innovation;interest;Interstitial Cystitis;Laboratories;Link;Literature;Measures;Mediating;Mediation;Modeling;Motor;Motor Cortex;Muscle;neuromechanism;neuromuscular;neuroregulation;noninvasive brain stimulation;Outcome Measure;Pain;Pain Measurement;pain reduction;Participant;participant enrollment;Patients;Pelvic Floor Muscle;Pelvic floor structure;Pelvis;Physical therapy;Play;Protocols documentation;Publishing;Randomized;recruit;repetitive transcranial magnetic stimulation;Reporting;Rest;Role;Symptoms;Testing;theories;United States;Woman;Work

PROJECT_TITLE: Motor cortical neuromodulation in women with Interstitial Cystitis/Bladder Pain Syndrome: reducing pain by improving brain and muscle activity

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Relevance. A newly developed method for measuring cholesterol chemical potential has shown that cell signaling and control of plasma membrane cholesterol is tightly linked. Identifying the linkage mechanisms may provide novel targets against pathologies and disease states.

PI_NAMEs: COHEN, FREDRIC S (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Back;Binding;Biological Assay;Biophysical Process;Caveolae;caveolin 1;Caveolins;Cell membrane;Cell Physiology;Cell Signaling Process;Cells;Cellular biology;Chemicals;Cholesterol;cholesterol control;Cholesterol Homeostasis;Closure by clamp;Communication;Cues;Data;dehydroergosterol;Devices;Disease;experimental study;Exposure to;extracellular;Feeds;flotillin;Fluorescence;Fluorescence Resonance Energy Transfer;FRAP1 gene;Growth Factor;inhibitor;Lead;Link;Measurement;Measures;Membrane;membrane activity;Methods;mTOR Signaling Pathway;novel;optogenetics;Pathology;Perfusion;Phosphorylation;Physiological;PIK3CG gene;Plasma Cells;Positioning Attribute;Regulation;Resolution;Rest;restoration;scaffold;Scaffolding Protein;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Site;Techniques;Tertiary Protein Structure;Testing;Time

PROJECT_TITLE: Biophysical Mechanisms of Cholesterol Homeostasis

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This T32 training program is designed to train new clinical, epidemiological, and translational infectious disease investigators, who are needed to discover better ways to diagnose, treat, and prevent serious emerging and re-emerging infections and other Global Health threats such as HIV/AIDS, influenza, meningitis, and antimicrobial-resistant infections. The program draws on multiple schools and colleges within the University of Minnesota, plus a Global Health course and an international site, to provide post-doctoral trainees – primarily Infectious Disease physicians – with the advanced skills needed for a successful career in infectious diseases research.

PI_NAMEs: BOULWARE, DAVID R (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Infectious Disease Training in Clinical Investigation

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Kidney Disease;Precision Medicine;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The threat to patient health from kidney cancer goes beyond the cancer itself, as following removal the remaining kidneys can lose function with a likelihood that is difficult to predict. Tests that can provide insight on the risk of declining kidney function may thus have a tremendous impact in improving patient health and reducing costs. By evaluating kidney cancer patients with diffusion-weighted magnetic resonance imaging, we propose to both better understand the cancer itself and potentially predict the risk of function loss before surgery.

PI_NAMEs: CHANDARANA, HERSH ;SIGMUND, ERIC EDWARD (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Address;allograft rejection;Allografting;angiogenesis;Anisotropy;Benign;Bilateral;Biological;Biological Markers;biomarker validation;Blood Vessels;Cancer Patient;Cellularity;Chronic;Chronic Kidney Failure;Classification;Clinic;Clinical;cohort;Contralateral;Contrast Media;cost;Creatinine;Data Set;Death Rate;Detection;Development;Diabetic Nephropathy;Diagnosis;Diagnostic tests;diagnostic value;Diffusion;diffusion anisotropy;Diffusion Magnetic Resonance Imaging;Discrimination;Disease;Excision;experience;Filtration;follow-up;Functional disorder;Glomerular Filtration Rate;Health;Heterogeneity;Histologic;Histopathology;Image;imaging approach;imaging biomarker;Imaging Techniques;improved;improved outcome;Incidental Discoveries;individualized medicine;Indolent;Injury;insight;Ipsilateral;Ischemia;Joints;Kidney;kidney allograft;Lesion;loss of function;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant - descriptor;Malignant Neoplasms;Measures;Methods;Microcirculation;Microscopic;Morbidity - disease rate;mortality;Motion;Neoplasms;Nephrectomy;non-invasive imaging;non-invasive monitor;Operative Surgical Procedures;overtreatment;Patients;Perfusion;personalized approach;Phenotype;Play;Postoperative Period;Predictive Value;Primary Lesion;Prognosis;prognostic;Proteinuria;Protocols documentation;Renal Carcinoma;Renal Cell Carcinoma;Renal function;Renal Mass;Renal Tissue;Reperfusion Injury;Research;response;Risk;risk prediction;Role;Sampling;Serum;Source;Specificity;Structure;Techniques;Testing;Texture;Tissues;tool;Tracer;Tubular formation;tumor;Validation;water diffusion;Work

PROJECT_TITLE: Advanced Diffusion Imaging for Management of Renal Cancer: Oncologic Control and Renal Functional Reserve - Resubmission - 1

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Mechanism of Action of a Novel Golgi-Targeted Anti-Cancer Agent PROJECT NARRATIVE The Golgi GOLPH3 pathway contains multiple cancer drivers, including GOLPH3, MYO18A, PITPNC1, and PI4KIII? that act together through the secretory pathway to promote many common human cancers. Through a phenotypic screen we have identified a small molecule inhibitor of the GOLPH3 pathway that preferentially kills cancerous cells compared to untransformed cells, but the direct target remains uncertain. We propose to determine the mechanism of action of this compound to provide new insight into mechanisms of oncogenic transformation and enable hit-to-lead optimization for new cancer therapeutic agents.

PI_NAMEs: FIELD, SETH J (contact);JACKSON, MICHAEL

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: addiction;Affect;Animal Model;Antineoplastic Agents;Biological Assay;Biological Models;Breast;cancer cell;cancer genomics;cancer therapy;Cancerous;Cell Culture Techniques;Cell membrane;cell transformation;Cells;Colorectal;Colorectal Cancer;combinatorial;Complex;Data;effective therapy;experimental study;F-Actin;Gene Expression;Genes;Genetic;Goals;Golgi Apparatus;Golgi Targeting;GOLPH3 gene;high throughput screening;Human;Image;Impairment;in vivo;inhibitor;insight;lead optimization;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Morphology;Neoplasm Metastasis;new therapeutic target;Normal Cell;novel;Oncogenes;Oncogenic;overexpression;Pathway interactions;Pharmaceutical Chemistry;Phenotype;PIK4CB gene;Predisposition;programs;Prostate;Proteins;Publishing;receptor;Regulation;Series;Set protein;Shapes;side effect;Signal Transduction;small molecule;small molecule inhibitor;small molecule libraries;Solid Neoplasm;success;targeted treatment;The Cancer Genome Atlas;Therapeutic;Therapeutic Agents;trafficking;Treatment Protocols;treatment strategy;tumor progression;United States National Institutes of Health;Vesicle

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lung;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Obstructive sleep apnea is an important disease since it is very common and can affect brain function. Older individuals with sleep apnea may have a special type of sleep apnea which can respond to certain medications which can stabilize breathing pattern. In theory, medications which improve sleep apnea could be used to improve breathing pattern, quality of life and possibly brain dysfunction (including risk of Alzheimer’s dementia) in older people at risk of this disease.

PI_NAMEs: MALHOTRA, ATUL  (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Acetazolamide;Adherence;Affect;Aging;aging related;Air;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Anatomy;Apnea;apolipoprotein E-4;Arousal;Biological Markers;Brain;brain dysfunction;Brain imaging;Breathing;Clinical;Clinical Research;Clinical Trials;Combined Modality Therapy;comparative effectiveness trial;Complex;Data;Deposition;design;Development;Dilator;Disease;disorder risk;Elderly;epidemiologic data;epidemiology study;experimental study;Frequencies;Functional disorder;Future;Genetic;Genetic Predisposition to Disease;high risk;hippocampal atrophy;Hippocampus;Hypoxia;Image;Impairment;improved;improvement on sleep;indexing;Individual;insight;Intervention;Link;Long-Term Care for Elderly;Medial;Memory;memory consolidation;Memory impairment;Methods;minimally invasive;Modeling;Molecular;MRI Scans;Multiple Abnormalities;Muscle;Neurocognitive;neuroimaging;Neuropsychology;novel;novel therapeutic intervention;novel therapeutics;Obstructive Sleep Apnea;older adult;older patient;Older Population;Outcome;Outcome Assessment;Oxidative Stress;Oxygen;Oxygen Therapy Care;Pathogenesis;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharyngeal structure;Population;Populations at Risk;positive airway pressure;Positron-Emission Tomography;pre-clinical;pre-clinical therapy;predicting response;Prevalence;prevent;Prevention trial;primary outcome;Publications;Publishing;Quality of life;randomized trial;recruit;respiratory;response;Risk;Risk Factors;Risk Reduction;Role;Selection for Treatments;Severities;Sleep;Sleep Apnea Syndromes;Sleep disturbances;Sleep Fragmentations;Subgroup;Symptoms;tau Proteins;Techniques;theories;Therapeutic;therapeutic target;Work

PROJECT_TITLE: Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The “Systems Science and Comparative and Cost-Effectiveness Research Training for Nurse Scientists” (S2CER2) research training program will provide nurse scientists with knowledge and skills to conduct interdisciplinary research to advance health equity. This competitive renewal will support pre- and postdoctoral trainees to conduct research focused on a) reducing and ultimately eliminating the systemic and structural inequities that place certain population groups at a disadvantage and impede health equity; b) developing and implementing interventions that address social determinants of health across the lifespan; and c) designing systems and models of care to address clinical, organizational, and policy challenges.

PI_NAMEs: POGHOSYAN, LUSINE  (contact);STONE, PATRICIA W.

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: comparative effectiveness;Cost effectiveness research;Nurses;Research Training;Science;Scientist;System

PROJECT_TITLE: Systems Science and Comparative and Cost-Effectiveness Research Training for Nurse Scientists (S2CER2)


ADMINISTERING_IC: AA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: Nashville

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The hypothesis that the negative affective states driven by alcohol withdrawal drive continued alcohol use through negative reinforcement has served as a foundational hypothesis guiding research in the alcohol field. D2 receptor containing medium spiny neurons (MSNs) in the nucleus accumbens are a negative reinforcement circuit that have been involved in alcohol drinking and undergo mechanistic changes in response to long-term alcohol exposure. Results from this project will examine the control of D2 MSNs in operant alcohol behavior before and after chronic intermittent ethanol exposure and provide a better understanding of the key motivational drive to take alcohol after long-term use.

PI_NAMEs: YOON, HYE JEAN  (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Abstinence;Address;Affect;Affective;Air;Alcohol abuse;alcohol behavior;Alcohol consumption;alcohol exposure;alcohol intervention;alcohol response;alcohol seeking behavior;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Amygdaloid structure;Animals;Aversive Stimulus;Behavior;behavioral response;Brain;Brain region;cell type;Cells;Chronic;Consumption;Cues;Data;Dopamine D2 Receptor;drinking;drinking behavior;efficacious treatment;Environment;Ethanol;experimental study;Exposure to;Fiber;Genetic;Goals;in vivo;Individual;Individual Differences;individual variation;Inhalation;Learning;Link;Measures;Mediating;Modeling;Motivation;Mus;negative affect;Negative Reinforcements;neural circuit;neuronal circuitry;Neurons;Nucleus Accumbens;Operant Conditioning;Optics;optogenetics;Pattern;Pharmaceutical Preparations;Phase;Phenotype;Photometry;Play;Population;Positioning Attribute;Process;receptor expression;Recording of previous events;recruit;Research;response;reward processing;Rewards;Role;Self Administration;Signal Transduction;Stimulus;Testing;Thinking;Time;tool;Training;vapor;Withdrawal

PROJECT_TITLE: Defining the cell-type specific control of alcohol drinking


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Sleep Research;Substance Misuse

PHR: PROJECT NARATIVE Alcohol use disorder and sleep disorders are commonly comorbid, and dysfunctional sleep significantly increases the risk of relapse in individuals abstaining from alcohol. My project will investigate synaptic mechanisms of ethanol and noradrenergic modulation in a population of wake-promoting dopamine neurons in the midbrain. In doing so, we hope to elucidate potential novel therapeutic targets for the treatment of dysfunctional sleep in the context of alcohol use disorder.

PI_NAMEs: PETERSEN, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acute;Adenosine;Adenosine Triphosphate;Adrenergic Receptor;Agonist;alcohol abstinence;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohol withdrawal syndrome;alertness;alpha-1 adrenergic receptors;American;antagonist;Architecture;Arousal;Astrocytes;Behavioral;Brain;Brain region;Calcium;Calcium Signaling;Cells;Chronic;chronic alcohol ingestion;comorbidity;designer receptors exclusively activated by designer drugs;Development;dopaminergic neuron;Dose;Electrophysiology (science);Ethanol;excitatory neuron;experience;experimental study;extracellular;Fiber;fluorescence imaging;Fluorescence Microscopy;G alpha q Protein;genetic approach;Goals;Human;in vivo;Individual;Investigation;Laboratory Finding;locus ceruleus structure;Measures;Mediating;Mental disorders;midbrain central gray substance;Midbrain structure;Modeling;mouse model;Mus;Neuroglia;Neurons;new therapeutic target;noradrenergic;Norepinephrine;novel;novel therapeutics;patch clamp;Pathologic;Periodicity;pharmacologic;Phenylephrine;Photometry;Physiology;Population;prevent;promoter;Purines;Purinoceptor;receptor;Relapse;relapse prevention;relapse risk;Reporting;response;Role;sensor;Series;Signal Transduction;Signaling Protein;Sleep;sleep difficulty;Sleep Disorders;Sleep disturbances;sleep regulation;Sleeplessness;Slice;Stress;Synapses;Synaptic plasticity;Synaptic Transmission;System;Testing;therapeutic target;Time;transmission process;Viral;virus genetics;Wakefulness;Withdrawal;Work

PROJECT_TITLE: Neuron-astrocyte interactions mediating ethanol and noradrenergic modulation of wake-promoting vPAG dopamine neurons


NIH_SPENDING_CATS: Data Science;Telehealth;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Social disadvantage and marginalization due to intersectionality of multiple social determinants of health are frequently associated with women’s adverse health outcomes. The use of data science and health information technology will improve research effectiveness in reducing health disparities among disadvantaged groups of women by providing various strategies that were not possible without these methodologies (e.g., increasing access to hidden populations, improving the precision of measurements). The proposed T32 program trains pre- doctoral and post-doctoral nursing scientists within interdisciplinary teams to have knowledge and skills to employ data science and/or health information technology in order to improve women’s health while considering the intersectionality of multiple social determinants of health.

PI_NAMEs: BRUNER, DEBORAH WATKINS (contact);HERTZBERG, VICKI STOVER

PROJECT_TERMS: Data Science;health information technology;intersectionality;Research Training;Women's Health

PROJECT_TITLE: Research Training in Women's Health and Intersectionality Using Data Science and Health Information Technology (WISDOM)


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Digestive Diseases;Immunization;Immunotherapy;Orphan Drug;Rare Diseases;Stomach Cancer;Women's Health Research

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Narrative This project tests three new strategies for improving the efficacy of anti-cancer antibodies and antibody-drug conjugates. Our optimization approaches may be used to enhance the efficacy of many anti-cancer therapies that are in current use, with application to all cancers that develop as solid tumors (including lung, breast, colorectal, and prostate cancers). Given the high rate of incidence of cancer, with approximately 1.7 million new cases and 600,000 deaths each year in the United States, this project, if successful, may have a substantial impact on human health.

PI_NAMEs: BALTHASAR, JOSEPH P (contact);SHAH, DHAVAL K

PROGRAM_OFFICER_NAME: SALOMON, RACHELLE

PROJECT_TERMS: Affinity;antagonist;anti-cancer;Antibodies;Antibody Affinity;Antibody Therapy;Antibody-drug conjugates;Antigens;Binding;Binding Sites;Biological;Blood Vessels;Breast;Bypass;cancer diagnosis;Cancer Patient;cancer therapy;Carcinoembryonic Antigen;Catabolism;cell growth;Cell Surface Receptors;Cessation of life;Cetuximab;Characteristics;chemotherapy;Chimeric Proteins;Clostridium;Collagen;collagenase;Colorectal Cancer;Data;design;Development;Dissociation;Drug Kinetics;Endosomes;Enzymes;ERBB2 gene;Evaluation;Exocytosis;Extracellular Fluid;Extracellular Matrix;Extravasation;Gemtuzumab Ozogamicin;Health;Hematologic Neoplasms;Human;human cancer mouse model;human model;Immunoglobulin Fragments;Immunoglobulin Idiotypes;improved;in silico;In Vitro;in vivo;Incidence;inhibiting antibody;Injections;Intercellular Fluid;Investigation;Lung;Lymphangiogenesis;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;mathematical model;Mediating;Modeling;models and simulation;Monoclonal Antibodies;mouse model;nanobodies;neonatal Fc receptor;novel;novel strategies;Oncology;Patients;Pharmaceutical Preparations;pressure;Prevalence;prevent;Prostate;receptor mediated endocytosis;research clinical testing;rituximab;Safety;side effect;Site;Solid Neoplasm;Syndrome;targeted cancer therapy;targeted delivery;Testing;Translations;Trastuzumab;Treatment Efficacy;treatment optimization;tumor;Tumor Antibodies;Tumor Antigens;United States;uptake;Vascularization;Work

PROJECT_TITLE: Pharmacokinetic strategies to increase monoclonal antibody uptake, distribution, and efficacy for treatment of solid tumors

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: RELEVANCE TO PUBLIC HEALTH, PROJECT NARRATIVE The regulation of gene expression controls the determination of cell types, and aberrant gene expression can cause diseases such as cancer. RegulomeDB will enable researchers, clinicians, and sophisticated computer programs to relate DNA variants that lie in previously poorly understood regions of the human genome to possible functions thereby helping us understand the genetic basis of human variation and disease.

PI_NAMEs: BOYLE, ALAN P;CHERRY, J. MICHAEL (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Adopted;Affect;Algorithms;Alleles;analysis pipeline;base;Binding;Biochemical;cell determination;cell type;ChIP-seq;Chromatin;chromatin modification;Classification;Communities;computer program;Computer software;Country;Data;data integration;Data Set;Data Sources;data wrangling;Databases;de novo mutation;deep ocean;Development;Disease;DNA;DNA Methylation;DNA sequencing;DNA-Protein Interaction;Documentation;Electronic Mail;Elements;epigenome;experimental study;Follow-Up Studies;functional genomics;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;Genome;genome sequencing;genome wide association study;genome-wide;genomic data;Genomics;Goals;heuristics;Human;Human Genome;Human Resources;improved;Individual;Investigation;Knowledge;knowledge integration;Laboratories;Large-Scale Sequencing;Literature;Maintenance;Malignant Neoplasms;Maps;Medical Research;meetings;Methods;Modeling;Modernization;Nucleic Acid Regulatory Sequences;Nucleotides;outreach;Process;Production;Public Health;Publishing;Pythons;Quality Control;random forest;Regulatory Element;Research;Research Personnel;Resolution;Resources;Sampling;Scoring Method;Site;social media;Source;Structure;System;Techniques;Tissues;tool;Training;transcription factor;Untranslated RNA;Update;Variant;web platform;web site;web-accessible;whole genome;Work

PROJECT_TITLE: RegulomeDB: A Resource for the Human Regulome


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Cocaine use disorder is a chronic, relapsing condition with severe public health impacts and limited effective treatment options. The current proposal aims to assess the acute effects of transcranial magnetic stimulation on electroencephalogram markers that contribute to poor treatment outcomes and has the potential to advance NIDA's objective of developing novel treatments that specifically target underlying neurobiological mechanisms of cocaine use disorder. This study can potentially improve transcranial magnetic stimulation treatment and ultimately lower the health burden of cocaine use disorder on the individual and society.

PI_NAMEs: WEBBER, HEATHER E (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Acute;addiction;Address;Adult;Anterior;Area;arm;Attention;Award;Biological Markers;Brain;career;career development;Characteristics;Chronic;cingulate cortex;clinical application;Clinical Trials;cocaine craving;Cocaine Dependence;cocaine use;Cocaine use disorder;Cocaine Users;Cognitive;cognitive neuroscience;craving;Crossover Design;Cues;Data;design;Development;Development Plans;Dimensions;Dopamine;drug reward;Drug user;effective therapy;Electroencephalography;Electrophysiology (science);FDA approved;Feedback;Foundations;Frequencies;Goals;Health;Heterogeneity;Image;improved;Impulsivity;Individual;Individual Differences;individualized medicine;insight;Knowledge;Left;Measures;Mental Depression;Mental disorders;Mentorship;Methods;Midbrain structure;Motivation;National Institute of Drug Abuse;neurobehavioral;neurobiological mechanism;Neurobiology;Neurosciences;non-drug;novel;Outcome;Outcome Measure;Patient Self-Report;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Positioning Attribute;Prediction of Response to Therapy;Prefrontal Cortex;primary outcome;Procedures;Public Health;Randomized, Controlled Trials;Relapse;relapse risk;Research;Research Personnel;Research Project Grants;response;reward processing;Rewards;Running;Severities;Site;Societies;Substance Use Disorder;success;Time;Training;Transcranial magnetic stimulation;treatment arm;Treatment outcome;Withdrawal;Work

PROJECT_TITLE: Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Infectious Diseases

ORG_CITY: SANTA CRUZ

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: The proposed research is relevant to public health and specifically to NIH’s mission to seek fundamental knowledge about the behavior of living systems and apply that knowledge to enhance health and reduce the burden of disease. Our experiments will fill a gap in our understanding of basic Helicobacter pylori physiology and metabolism during the chronic growth state. This work will pave the way for new treatments that enhance antibiotic cure of H. pylori.

PI_NAMEs: OTTEMANN, KAREN M (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acids;Adopted;Affect;Amoxicillin;Antacids;Antibiotics;Bacteria;Behavior;Biochemistry;burden of illness;Cancer Etiology;Carbon;Cessation of life;Chronic;chronic infection;Chronic Phase;Clarithromycin;Colony-forming units;Combined Modality Therapy;Data;design;Disease;Effectiveness;Epithelium;experimental study;Frequencies;Gastric ulcer;Gene Proteins;Genetic Transcription;Gland;Green Fluorescent Proteins;Growth;Growth Inhibitors;Health;Helicobacter Infections;Helicobacter pylori;Human;improved;in vivo;Incidence;Individual;Infection;inhibitor;innovation;insight;Knowledge;malignant stomach neoplasm;Measurement;Measures;Metabolism;metabolome;Microbe;Mission;Molecular Biology;mouse model;Mus;mutant;Mycobacterium tuberculosis;Nature;Neisseria;Nutrient;Organism;Outcome;pathogen;pathogenic bacteria;Persons;Physiology;Population;Population Sizes;Production;Proteins;Proton Pump Inhibitors;Public Health;Publishing;Pump;Refractory;Research;Ribosomal Proteins;Ribosomes;Rodent Model;Scheme;Signal Transduction;Solid;Source;Stomach;synergism;Testing;Therapeutic;therapy development;Time;Translational Repression;Translations;Treatment Effectiveness;Ulcer;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Understanding and manipulating chronic Helicobacter pylori to enhance treatment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative: The proposed study will examine if there are differential effects of angiotensin converting enzyme inhibitor (ACEI) subtypes on 1) motoric, 2) cognitive, and 3) neurodegenerative and vascular outcomes among participants in 2 nationally available cohorts. It will be the first to examine these outcomes in older adults on ACEI without dementia. Early identification of older adults at risk for the development of cognitive impairment and functional decline, coupled with a better understanding of how this commonly prescribed medication affects cortical regions associated with dementia, is of paramount importance as a prelude to identification of targeted therapies to slow the progression of dementia.

PI_NAMEs: GEORGE, CLAUDENE  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acetylcholine;Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Angiotensin II;Angiotensin-Converting Enzyme Inhibitors;Attention;Award;Biological;Biometry;Blood Pressure;Blood Vessels;blood-brain barrier crossing;Brain;career;career development;Categories;Cerebrovascular Circulation;Clinical;Clinical Markers;clinically relevant;Cognition;Cognitive;cohort;Consumption;Coupled;cytokine;Data;Databases;Dementia;dementia risk;design;Detection;Development;Diabetes Mellitus;Drug Prescriptions;Early identification;Epidemiologic Methods;evidence base;executive function;experience;falls;functional decline;Gait;Gait abnormality;Goals;Grant;Harm Reduction;Health and Retirement Study;Heart failure;hippocampal atrophy;Hypertension;Impaired cognition;improved;Incidence;Individual;Inflammatory;Investigation;Kidney;Kidney Diseases;Knowledge;Lacunar Infarctions;Learning;Link;longitudinal analysis;Longitudinal, observational study;Memory;memory consolidation;Memory impairment;memory retrieval;Mentored Patient-Oriented Research Career Development Award;Microvascular Dysfunction;mild cognitive impairment;Modality;Motor;Nerve Degeneration;neural correlate;Neurobiology;neuroimaging;Neurons;neuropathology;Neuropsychological Tests;older adult;Older Population;Outcome;Participant;Pathologic;Pathology;Pathway interactions;Peripheral;Pharmaceutical Preparations;Physical Performance;Physicians;Population;Prevalence;Prevention;rate of change;Registries;Renin-Angiotensin System;Research;Research Personnel;Research Training;Risk;Role;skills;System;targeted treatment;Techniques;Testing;Time;Training;White Matter Disease;Work

PROJECT_TITLE: Utility of Centrally Acting Angiotensin Converting Enzyme Inhibitors to slow the progression of Dementia


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Narrative Polygenic risk scores may help identify people at the highest risk for common diseases like cancer and cardiovascular disease. Through participation in the Electronic Medical Records and Genomics network, Northwestern will test the usefulness of polygenic risk scores and the ability of such risk scores to change health care outcomes in people from different age groups, socioeconomic backgrounds and diverse ancestries.

PI_NAMEs: CHISHOLM, REX L (contact);MCNALLY, ELIZABETH M;RASMUSSEN-TORVIK, LAURA J

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Adherence;age group;alternative communication;Area;Behavior;Behavioral;biobank;Cardiovascular Diseases;care outcomes;Clinical;clinical care;clinical decision support;clinical decision-making;clinical implementation;Collection;Communication;Communication Tools;community clinic;Community Hospitals;Community Networks;Computerized Medical Record;Data;data warehouse;Deposition;Diagnosis;Disease;disorder risk;DNA;Educational Materials;Electronic Health Record;Electronic Medical Records and Genomics Network;Electronics;Enrollment;Ensure;Epidemiology;ethical, legal, and social implication;ethnic diversity;ethnic minority;Ethnic Population;expectation;experience;Family;Family history of;Genes;Genetic;Genetic Risk;Genomic medicine;Genomics;Genotype;Goals;health disparity;health management;Health system;Healthcare;high risk;improved;Individual;Informatics;Information Technology;Infrastructure;innovation;Intervention;Knowledge;Leadership;Link;Malignant Neoplasms;Medical;Medical center;Medicine;Monitor;Morbidity - disease rate;mortality;novel;Outcome;Participant;participant retention;Patient Education;Patients;Performance;Persons;Pharmacogenomics;Phase;Phenotype;Pilot Projects;polygenic risk score;Population;Population Genetics;Population Heterogeneity;Positioning Attribute;prevent;programs;Provider;Publishing;racial diversity;racial minority;racial population;rare variant;Recording of previous events;recruit;Research Personnel;Risk;Risk Assessment;Risk Estimate;Risk Management;Role;Site;smartphone application;socioeconomics;Specific qualifier value;success;Symptoms;Techniques;Testing;theories;Trust;uptake

PROJECT_TITLE: Northwestern Genomic Risk Assessment and Management Program


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: NARRATIVE Better grasp of the mechanism underlying chromosomal rearrangements and mutagenesis is highly relevant to public health because genome-altering events are central to understanding both the changes in cells at the onset of tumorigenesis and during the treatment of cancers with chemotherapeutics that function by damaging DNA and elevating genome instability. The results from the proposed research is expected to contribute to understanding how genome instability-inducing factors such as non-canonical nucleosides and secondary DNA structures are regulated and connected to the transcription process and are therefore applicable to the part of NIH’s mission to develop fundamental knowledge regarding development and treatment of cancer.

PI_NAMEs: KIM, NAYUN  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Adverse event;Binding;cancer therapy;Cell Cycle;Cell Physiology;Cells;Chromosomal Rearrangement;Chromosomes;Complex;density;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Structure;DNA-Binding Proteins;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;Event;Frequencies;G-Quartets;G1 Phase;G2 Phase;genetic approach;Genetic Recombination;Genetic Transcription;Genome;genome integrity;Genomic Instability;Goals;grasp;In Vitro;in vivo;innovation;Investigation;Knowledge;Link;Malignant Neoplasms;metaplastic cell transformation;Mission;model organism;Modeling;Mutagenesis;Mutation;novel;Nucleosides;Process;programs;protein complex;Proteins;Public Health;Research;response;Ribonucleotides;Saccharomyces cerevisiae;Stress;Structure;System;Testing;Therapeutic;Topoisomerase;Torsion;Transcription Process;Transcriptional Activation;tumorigenesis;United States National Institutes of Health;Uracil;Work

PROJECT_TITLE: Mechanism of transcription-associated genome instability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: N/A – no change to Public Health Relevance Section

PI_NAMEs: GRITSMAN, KIRA  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Abnormal Cell;Affect;aging population;Alternative Splicing;Animal Model;Arginine;Autophagocytosis;Biological Models;Cell Differentiation process;Cells;Cellular Stress;Clinical;Cytokine Signaling;cytopenia;Data;Data Set;Defect;Dependence;Development;Disease;DNA Damage;drug candidate;Dysmyelopoietic Syndromes;Dysplasia;erythroid differentiation;Event;exon skipping;Exons;Gene Expression;Gene Expression Profile;Genes;Genomic Instability;Growth Factor;Hematopoiesis;Hematopoietic;Hematopoietic Cell Growth Factors;hematopoietic stem cell differentiation;Hematopoietic stem cells;Hemorrhage;Human;Impairment;improved;Infection;inhibitor;Knock-out;Knockout Mice;Lead;Link;Lipids;Maintenance;Messenger RNA;Metformin;Modeling;mortality;mouse model;Mus;mutant;Mutation;Myelogenous;novel therapeutic intervention;Nuclear;Pathogenesis;Pathway interactions;Patients;Pattern;Persons;pharmacologic;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;PIK3CG gene;Play;prevent;Process;Protein Isoforms;Protein Kinase;Proteins;Proto-Oncogene Proteins c-akt;PTEN gene;public health relevance;Quality Control;Recycling;Reporting;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Serine;Signal Transduction;Spliceosomes;stem cell biology;stem cell function;stem cell genes;stem cells;Testing;Therapeutic;therapeutic target;Transfusion

PROJECT_TITLE: PI3 Kinase Inactivation in Myelodysplastic Syndrome

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cervical Cancer;Genetics;Human Genome;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE This project aims to identify and functionally characterize novel targets for treating women with invasive cervical cancer.

PI_NAMEs: RADER, JANET S. (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Affect;Automobile Driving;Cancer cell line;cancer survival;Cell Proliferation;Cell Survival;Cells;cervical carcinogenesis;Cessation of life;chemotherapy;ChIP-seq;Chromatin Loop;Chromosomes;Cisplatin;Clinical;clinical biomarkers;Clinical Data;clinically relevant;Clonality;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complementary DNA;Complex;Copy Number Polymorphism;CRISPR/Cas technology;cytotoxicity;Data;Data Set;design;Disease;Disease Progression;DNA;DNA amplification;DNA Methylation;DNA sequencing;Elements;Enhancers;epigenome;epigenomics;Event;fitness;fluorodeoxyglucose positron emission tomography;Frequencies;Gene Expression;Gene Modified;gene network;Genes;Genome;genome sequencing;Genomics;Goals;Haplotypes;Histology;HIV;human papilloma virus oncogene;Human Papillomavirus;Immunofluorescence Immunologic;improved;In Vitro;in vivo;individual patient;insight;integration site;Invaded;knock-down;knockout gene;low socioeconomic status;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;Methylation;migration;Minority Groups;Minority Women;Modification;Molecular;Multiomic Data;multiple omics;nanopore;Neoplasm Metastasis;new technology;novel;novel strategies;novel therapeutics;Nucleic Acid Regulatory Sequences;Oncogenes;Pathologic;Pathology;Pathway interactions;Patients;Positron-Emission Tomography;protein expression;Recurrence;Research;Residual Neoplasm;Resistance development;response;Role;Sampling;screening;Small Interfering RNA;targeted treatment;Technology;Testing;The Cancer Genome Atlas;therapeutic target;Tissues;Transcript;Transcriptional Regulation;transcriptome;transcriptome sequencing;treatment and outcome;tumor;tumor microenvironment;Validation;Viral;whole genome;Woman;women's treatment;Xenograft Model;years of life lost

PROJECT_TITLE: Enlisting HPV integration events to illuminate drivers and target treatment in invasive cervical cancer

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ORG_CITY: LAWRENCE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Project Narrative The mission of the Chemical Biology Training Program is to provide multidisciplinary training for graduate students, which integrates all aspects of chemistry and biology. The program fosters interactions among the faculty and students from departments in the College of Liberal Arts and Sciences and the School of Pharmacy. The overarching goal of the proposed training program is to produce a diverse population of scientists who are well-trained in rigorous and transparent scientific methodology, experimental design, and data interpretation, and who have developed the professional skills required to find success in a broad range of research-intensive or research-related careers.

PI_NAMEs: ACKLEY, BRIAN DOUGLAS (contact);WHELAN, REBECCA JEAN

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Biology;Chemistry;Training

PROJECT_TITLE: Graduate Training at the Biology-Chemistry Interface

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative Research of the brain receptor functions holds a promise for better diagnostic tools and drugs that could be tailored to the individual needs, thereby eliminating or reducing side effects and even providing a way for prevention of disease. Real time imaging of receptor modulation using simultaneous phMRI and PET will challenge the present theories of signaling and synaptic plasticity during degenerative processes. The results of receptor modulation can be readily utilized in the drug development for dopamine-glutamate regulation related disorder, like Parkinson’s disease, schizophrenia or drug abuse.

PI_NAMEs: BROWNELL, ANNA-LIISA  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: addiction;Age;Agonist;alpha synuclein;Amphetamines;Animal Disease Models;Animal Diseases;antagonist;Area;Basal Ganglia;Behavioral;behavioral study;benzonitrile;Brain;brain circuitry;Brain Mapping;Brain region;brain research;cerebral blood volume;chronic pain;Clinical Trials;Cognitive;Complex;Corpus striatum structure;Data;Denervation;density;design;Diagnostic;diagnostic tool;Disease;disease diagnostic;disorder prevention;Dopamine;Dopamine D2 Receptor;Dopamine Receptor;dopamine transporter;Drug abuse;Drug Addiction;Drug Design;drug development;Drug Targeting;Epilepsy;Experimental Animal Model;Failure;Female;Future;Gene Modified;Glutamates;GRM5 gene;Image;Imaging ligands;imaging study;in vivo imaging;Individual;instrumentation;Lesion;Ligands;Limbic System;Magnetic Resonance Imaging;male;Maps;Measures;Mediating;metabotropic glutamate receptor 4;Metabotropic Glutamate Receptors;Modeling;Mood Disorders;Nerve Degeneration;Neurobiology;neurochemistry;Neuronal Plasticity;neurotoxicity;neurotransmission;Neurotransmitters;Oxidopamine;Parkinson Disease;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;positive allosteric modulator;Positron-Emission Tomography;postsynaptic;presynaptic;Presynaptic Receptors;Process;pyridine;radioligand;Rattus;real-time images;receptor;receptor function;Regulation;response;Role;Schizophrenia;sensor;serial imaging;side effect;Signal Transduction;Specificity;Support System;Symptoms;Synapses;Synaptic Cleft;Synaptic plasticity;Synaptic Receptors;System;Techniques;theories;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Time;time use;transmission process;Tropanes;Up-Regulation

PROJECT_TITLE: Simultaneous PET/phMR studies on interplay of mGlu/dopamine receptors in PD-like neurodegeneration

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Mitochondria are the powerhouse of continuously beating heart muscle cells. Mitochondrial dysfunction is implicated in and contributes to heart and other diseases. This study will address the importance of a protein complex in monitoring mitochondrial health in the healthy and stressed heart. This research will identify potential therapeutic targets for heart failure and will also produce broadly applicable, basic biological insights.

PI_NAMEs: SU, HUABO  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Ablation;Adaptor Signaling Protein;Adult;Aging;Autophagocytosis;Biochemical;Biological;Biological Assay;Biological Process;Biotinylation;Cardiac;Cardiac Myocytes;Cell Death Induction;Cell Physiology;Cullin 5 Protein;Cullin Proteins;Data;Development;Disease;elongin B;Enzymes;experimental study;feasibility testing;Health;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;Homeostasis;human disease;Impairment;improved;In Vitro;in vivo;insight;Label;Ligase;Link;LoxP-flanked allele;Mediating;Membrane Potentials;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Molecular;molecular dynamics;Monitor;mouse model;Multiprotein Complexes;Mus;novel;overexpression;Parkin;Pathologic;Phosphorylation;Phosphotransferases;Physiological;PINK1 gene;premature;pressure;Process;protein complex;Proteins;Proteomics;Quality Control;receptor;recruit;Regulation;Reporter;Research;Respiration;Role;Scaffolding Protein;Signal Transduction;Stress;System;Tamoxifen;Testing;therapeutic target;Ubiquitin;Ubiquitination

PROJECT_TITLE: Mitochondrial quality control in the heart

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Argonaute proteins in animals, plants, fungi, and bacteria use small pieces of RNA or DNA to find and control genes. Studying how Argonautes work has already led to small RNA drugs to turn off fatal human disease genes. The proposed research will reveal how organisms make small RNAs and use Argonautes to control development and reproductive health.

PI_NAMEs: ZAMORE, PHILLIP D (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Animals;Bacteria;Bacterial Genome;Biochemical;Biochemistry;Biology;Chromosomes;Compensation;Complex;computer studies;design;Development;Dicer Enzyme;DNA;DNA biosynthesis;DNA Sequence;DNA Topoisomerase IV;Ensure;Evolution;Exclusion;experimental study;fly;fungus;Gene Expression;Genes;Genetic;Genetic Transcription;Genomic Segment;Germ Cells;Goals;Guide RNA;human disease;improved;in vivo;insight;Male Infertility;Mediating;MicroRNAs;Molecular;Moths;mouse genetics;mRNA Stability;Mus;Mutation;Organism;Pathway interactions;Pharmaceutical Preparations;piRNA;placental mammal;Plants;pre-miRNA;Process;Protein Family;Proteins;Reproductive Health;Research;Ribosomes;RNA;RNA Precursors;RNA Sequences;Role;Small RNA;Specificity;sperm cell;Spermatocytes;Thermus thermophilus;Transcript;Translations;Work

PROJECT_TITLE: Understanding the Evolution, Biology, and Molecular Mechanism of Argonaute Proteins


ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  In heart or lung failure, people may need circulatory support through mechanical pumps. Flow in these systems cam lead to key changes in proteins and cells within the blood that could simultaneously lead to bleeding or blood clots. We are investigating this process and we are evaluating potential ways to reduce the risk for bleeding or blood clots.

PI_NAMEs: BARK, DAVID  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Acquired von Willebrand disease;ADAMTS;Affect;Anticoagulants;Anticoagulation;Automobile Driving;Binding;Biological Assay;Biomedical Engineering;Blood;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Cell Death;Cells;cleavage factor;Collagen;Complex;Complication;Cytoplasmic Granules;design;Environment;Equilibrium;Event;Exhibits;experience;Exposure to;Extracorporeal Circulation;Functional disorder;functional loss;Goals;Growth;Heart failure;Hematologist;hemodynamics;Hemorrhage;Hemostatic Agents;Hemostatic function;Heparin;Impairment;improved;inhibitor;Knowledge;Lead;Literature;lung failure;mechanical circulatory support;Mechanics;Medical Device;Membrane;Metalloproteases;microvesicles;Molecular Weight;new therapeutic target;Pathologic;Pathway interactions;Patients;pediatric patients;Persons;Pharmacologic Substance;Phosphatidylserines;Plasma Proteins;Platelet Activation;Platelet aggregation;Platelet Count measurement;Platelet Glycoproteins;Play;Positioning Attribute;prevent;Process;Proteins;Publications;Pump;receptor;Research;response;Risk;Risk Reduction;Role;shear stress;Signal Pathway;Signal Transduction;Surface;System;Therapeutic;Thrombin;Thrombocytopenia;Thrombosis;thrombotic;Thrombus;tool;ventricular assist device;Viscosity;von Willebrand Factor;Whole Blood;Work

PROJECT_TITLE: Impact of turbulence on blood in mechanical circulatory support


PHR: Despite years of effective suppressive antiretroviral therapy (ART), latent HIV-infected cells can persist in people with HIV (PWH) and reintroduce disseminated HIV infection after cessation of ART, preventing the functional cure of HIV-infected individuals. The anti-HIV-1 immune response in most patients is inadequate to effectively eliminate reactivated cells, necessitating the development of strategies to boost the anti-HIV immune response to enable it to clear the reservoir after reactivation. We postulate that by redirecting CD8 T cells that are highly effective in controlling chronic latent CMV infection to target and kill HIV-infected cells, we can boost the HIV- specific immune response in PWH to prevent recurrent viremia after the cessation of ART and contribute to providing a functional cure of HIV infection.

PI_NAMEs: ALMO, STEVEN C.;GOLDSTEIN, HARRIS  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YAN

PROJECT_TERMS: Antigen-Presenting Cells;antigen-specific T cells;antiretroviral therapy;Architecture;Biological;Biological Products;Bispecific Antibodies;CD28 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;chimeric antigen receptor T cells;Chronic;chronic infection;Clinical;Coupled;cytokine;Cytokine Signaling;Cytomegalovirus;Cytomegalovirus Infections;Cytoplasm;cytotoxic CD8 T cells;design;Development;dimer;Disease remission;engineered T cells;Epitopes;exhaustion;Exhibits;Fc domain;HIV;HIV Envelope Protein gp120;HIV Infections;HIV-1;Immune;Immune checkpoint inhibitor;Immune response;immune stimulatory agent;Immune system;Immunity;Immunotherapeutic agent;improved;In Vitro;in vivo;Individual;Infusion procedures;Knowledge;latent HIV reservoir;Lentivirus Vector;Ligands;Link;Malignant Neoplasms;Memory;Mutation;neoplastic cell;novel;novel strategies;Patients;Peptide/MHC Complex;Peptides;Peripheral Blood Mononuclear Cell;Persons;Phenotype;prevent;Production;Proliferating;receptor;Receptor Signaling;Recurrence;Relapse;Residual Neoplasm;resilience;Resistance;response;scaffold;Signal Transduction;Structure;T cell response;T memory cell;T-Cell Receptor;T-Lymphocyte;Time;Viral;Viral Physiology;Viremia;Virus

PROJECT_TITLE: Amplifying and Redirecting CMV-specific CD8 T cells to provide sustained control of HIV infection

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative This project will utilize human intracranial recording and stimulation to quantify the unique contributions of the posterior cingulate cortex (PCC) to episodic memory. Specifically, we will use single unit and population measures of neural activity to test a new account of PCC function which focuses on the executive processes needed to support memory retrieval and memory based decisions. By studying PCC, a convergence zone of memory and executive systems, progress can be made in elucidating how the failure to successfully leverage past experiences in daily behavior can occur as a common symptom of both neurodegenerative disease (e.g. Alzheimer’s disease) and multiple psychiatric conditions (e.g. schizophrenia) implicating PCC dysfunction.

PI_NAMEs: FOSTER, BRETT  (contact);HAYDEN, BENJAMIN Y

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Alzheimer's Disease;Anatomy;Animal Model;Area;Behavior;behavior test;Behavioral;Brain;Cerebral cortex;cingulate cortex;Cognitive;cognitive function;common symptom;Complex;Consensus;Data;design;Disease;Dissociation;Dorsal;Electric Stimulation;Electrophysiology (science);Elements;Episodic memory;Event;Evoked Potentials;executive function;experience;experimental study;Failure;Fostering;Frequencies;Functional disorder;Goals;Hippocampus;Homologous Gene;Human;Human Characteristics;human model;Infrastructure;insight;learned behavior;Literature;Location;Maps;Measures;medial temporal lobe;member;Memory;memory encoding;Memory impairment;memory process;memory retrieval;Mental Depression;Metabolism;Modeling;Monkeys;multisensory;Nerve Degeneration;neural;Neurodegenerative Disorders;neuroimaging;Neurons;neurosurgery;news;nonhuman primate;novel;Patients;Perception;Play;Population;Process;Regulation;Research;response;Retrieval;Rodent;Role;Schizophrenia;Signal Transduction;Site;System;Testing

PROJECT_TITLE: Posterior cingulate cortex and executive control of episodic memory

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Public health response to infectious disease epidemics requires multidisciplinary, quantitative, and critical skills to address all aspects of control from preparedness to elimination. The proposed training program will provide foundational training in epidemiological study design and inference, ethics, and advanced methodological training in one of three methodological areas: (1) Transmission Modeling and Infectious Disease Dynamics, (2) Molecular Epidemiology and Phylogenetics, and (3) Disease Mapping and Burden Estimation. As part of this program, trainees will apply these methods to practical issues in policy and disease control through practicums and projects in translational research and implementation.

PI_NAMEs: MOSS, WILLIAM J (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Infectious Disease Epidemiology;research in practice;Translating

PROJECT_TITLE: Research in practice: translating infectious disease epidemiology RIP-TIDE

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ORG_CITY: HANOVER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Conserved membrane fusion mechanisms, essential for cell growth, neurotransmission, and hormone secretion, are "hijacked" by invading bacteria and viruses which must enter the lysosome/vacuole to infect and cause human disease. We discovered, cloned, purified, and study a central catalyst of this process, termed HOPS, which is conserved from yeast to humans and is known to be essential for pathogens to gain access to the lysosome, an essential step in infection. Our advanced studies of HOPS, including development of facile assays, are a prerequisite for the development of drugs which thereby target pathogen invasion.

PI_NAMEs: WICKNER, WILLIAM TOBEY (contact)

PROJECT_TERMS: Bacteria;Binding Proteins;Biological Assay;Biological Models;catalyst;cell growth;Cells;Complex;Cytolysis;Development;drug development;Elements;Genes;Goals;Hormone secretion;Human;human disease;Humulus;In Vitro;Individual;Infection;insight;Invaded;Lipid Bilayers;Lipids;Lysosomes;Membrane;Membrane Fusion;Molecular Chaperones;neurotransmission;novel;pathogen;pathogenic bacteria;pathogenic virus;Pathway interactions;Process;Protein Array;Proteins;proteoliposomes;reconstitution;Role;SNAP receptor;Structure;Vacuole;Virus;Yeasts

PROJECT_TITLE: Mechanisms of Membrane Fusion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Food Allergies;Immunization;Nutrition;Pediatric;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative Allergies are major causes of pregnancy complications and neonatal morbidity. This project explores the function of maternal IgD transferred to the fetus during pregnancy in the protection from neonatal allergy. The novel scientific concept and clinical implications of this project fit well both the scientific and public health goals of NIH, and will have a significantly positive impact on how to innovatively and more efficiently tackle early infant morbidity due to increasing incidences of allergies.

PI_NAMEs: CHEN, KANG  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: 1 year old;Adhesions;Adoptive Immunotherapy;Adult;Affect;Allergens;Allergic;allergic response;Anaphylaxis;Anti-Allergic Agents;Antibodies;antimicrobial;Apical;Basophils;Binding;Biochemical;Birth;Blood;Blood specimen;Cattle;CD44 gene;Cell Culture Techniques;Cell Line;Child;Child Health;Circulation;Clinical;Cues;Data;desensitization;design;Diphtheria-Tetanus-acellular Pertussis Vaccines;Disease;Economic Burden;Education;effective therapy;egg;Environment;Equilibrium;Exhibits;Fc Receptor;Female;fetal;Fetus;Food;food allergen;Food Hypersensitivity;Galactose Binding Lectin;Health;health goals;Human;Hypersensitivity;IgE;imaging modality;Imaging Techniques;Immune;immune function;Immune signaling;Immunize;Immunoglobulin D;Immunoglobulin G;Immunologics;improved;in utero;In Vitro;in vivo;Incidence;Industrialization;Infant;infant morbidity;Infection;innovation;interest;Life;male;maternal vaccination;Mediating;Microbe;Milk;Morbidity - disease rate;Mothers;mouse model;Mucous Membrane;Mus;Nature;Neonatal;neonatal Fc receptor;neonatal health;neonatal immune system;neonatal mice;neonatal morbidity;neonate;Newborn Infant;novel;oral immunotherapy;Partner in relationship;pathogen;Perinatal;peripheral blood;Physiological;Placenta;placental transfer;Predisposition;Pregnancy;Pregnancy Complications;prevent;Production;prophylactic;Public Health;pup;Reporting;respiratory;Respiratory Mucosa;Respiratory Tract Infections;response;Retroviridae;Role;Severities;small hairpin RNA;social;Sorting;Specimen;Sterility;Surface;trans-Golgi Network;transcytosis;trophoblast;Umbilical Cord Blood;United States National Institutes of Health;Vaccine Design;vaccine immunotherapy;Vaccine Production;Vaccines;Villous

PROJECT_TITLE: Mechanism and function of transplacental IgD

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: TALLAHASSEE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Synaptic dysfunction is common to neurodevelopmental disorders and is considered a major contributor to behavioral deficits. This study will uncover novel axonal mechanisms that initiate abnormal synaptic development in Fragile X syndrome, by combining cell group specific genetic approaches with in vivo time-lapse structural and functional imaging. The results are applicable in understanding the generation of synaptic pathophysiology in neurodevelopmental disorders.

PI_NAMEs: WANG, YUAN  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Acute;adhesion receptor;Adhesions;autism spectrum disorder;Axon;Axonal Transport;Behavioral;Brain;Calcium;Cell Adhesion Molecules;Cells;Chick Embryo;Chickens;Cues;Development;Elements;Embryo;Evolution;Exocytosis;FMR1 gene;Fragile X Syndrome;Functional disorder;Functional Imaging;functional loss;Generations;genetic approach;genetic manipulation;Glutamates;Goals;Human;Image;Impairment;in vivo;Inherited;Intellectual functioning disability;knockout animal;Knowledge;Location;Mammals;Mediating;Molecular;neural circuit;Neurodevelopmental Disorder;neuropathology;neurotransmission;neurotransmitter release;novel;novel therapeutics;Outcome;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physiological;postsynaptic;presynaptic;presynaptic neurons;Presynaptic Terminals;prevent;Probability;Process;Protein Deficiency;protein expression;protein function;Proteins;Publishing;Regulation;Resolution;RNA-Binding Proteins;Role;sensor;structural imaging;Synapses;Synaptic plasticity;Synaptic Transmission;Synaptic Vesicles;synaptogenesis;synaptotagmin;System;Testing;therapeutic candidate;therapy development;Time;Translations;Up-Regulation;Vesicle

PROJECT_TITLE: Axonal FMRP in Synaptic Development

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Cryptococcus neoformans (C. neo), is one of the most significant fungal pathogens worldwide, with few treatment options. The ones that do exist are often lengthy and highly toxic. Veterans are at high risk of fungal infections due to underling immune deficiencies (especially from cancer therapy) and unique deployment- related exposures. This project studies how the fungi producing a specific sugar (trehalose) leads to protecting it from the immune system during infection. The project investigates multiple levels of the immune defenses that are rendered ineffective when C. neo is capable of making trehalose. Interfering in this sugar production may lead to new treatment options which could allow the immune system to get the upper hand on C. neo infections and clear the infection. Our results could have implications in other fungal infections, as trehalose synthesis is typical throughout, and is even found in some bacteria species. As such our results can have a far- reaching impact on antimicrobial treatments for Veterans.

PI_NAMEs: GOUGHENOUR, KRISTIE D (contact)

PROJECT_TERMS: Affect;Alveolar;Alveolar Macrophages;Anabolism;Animals;anti-fungal agents;antimicrobial;arm;Bacteria;Biological;cancer therapy;career;career development;Cells;Collectins;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;Data;Development;Disaccharides;Excision;Exposure to;fitness;fungicide;fungus;Future;Goals;Health;high risk;Host Defense;Human;Iatrogenesis;Immune;Immune Evasion;Immune response;Immune system;immunodeficiency;Immunologic Memory;Immunologic Stimulation;improved;In complete remission;Infection;inhibitor;Innate Immune Response;inorganic phosphate;insight;Integration Host Factors;Intercept;Kinetics;Laboratories;Learning;Lung;Lung Diseases;Lung infections;Mammalian Cell;Mediating;Memory;Mentors;Microbe;microbial;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mus;Mycoses;neutrophil;new technology;novel;opportunistic pathogen;Outcome;pathogen;Pathogenesis;pathogenic fungus;Pathway interactions;Phagocytosis;post-doctoral training;Process;Production;programs;Pulmonary Surfactant-Associated Protein A;Pulmonary Surfactant-Associated Protein D;recruit;Research;Research Personnel;Research Training;response;Risk;Role;skills;Stress;sugar;surfactant;T-Lymphocyte;Training;Training Programs;Trehalose;Veterans;Virulence;Virulence Factors;Work

PROJECT_TITLE: Mechanism of cryptococcal fitness, innate defense subversion, and the adaptive immune skewing in lungs


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Vector-Borne Diseases;Zika Virus

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative This project will create tools that use viral genome data to make actionable public health inferences. Through analysis of evolutionary patterns of seasonal inﬂuenza virus, we will guide the process of vaccine strain selection and thereby improve vaccine efﬁcacy. Additionally, we will use sequence data from viral outbreaks to aid contact tracing and epidemiological investigation of epidemic and pandemic spread.

PI_NAMEs: BEDFORD, TREVOR BC (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: 2019-nCoV;African;American;bioinformatics pipeline;Communicable Diseases;Contact Tracing;COVID-19 pandemic;Data;Data Set;Dengue Virus;Disease Outbreaks;Early Diagnosis;Ebola;Ebola virus;Epidemic;Epidemiologist;Epidemiology;epidemiology study;Evolution;Future;Genes;Genetic;genomic data;genomic epidemiology;Genomics;Geography;Goals;Human;Immunity;improved;Influenza;influenza virus vaccine;influenzavirus;innovation;Methodology;Methods;Modeling;Monitor;Mumps virus;novel;outbreak response;pandemic disease;pathogen;pathogenic virus;Pattern;Population;Predisposition;Process;Public Health;public health intervention;seasonal influenza;Time;tool;transmission process;Tuberculosis;United States;Update;vaccine efficacy;Vaccines;Variant;Viral;Viral Genome;viral genomics;Viral Load result;viral outbreak;Virus;web site;Work;ZIKA;Zika Virus

PROJECT_TITLE: Real-time tracking of virus evolution for vaccine strain selection and epidemiological investigation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Chronic Pain;Immunotherapy;Infectious Diseases;Neurosciences;Opioids;Pain Research;Urologic Diseases

ORG_CITY: CHICAGO

ORG_DEPT: UROLOGY

ORG_STATE: IL

PHR: Chronic pelvic pain is the hallmark of patients with chronic pelvic pain syndrome (CPPS), a category of prostatitis that is a significant source of morbidity in American men. Currently, there is lack of effective mechanistic therapies for CPPS and there is an urgent unmet medical need. This project will evaluate mechanisms behind a potential therapeutic for chronic pelvic pain that was obtained from prostate commensal bacteria and can modulate immune and neuronal functions.

PI_NAMEs: THUMBIKAT, PRAVEEN  (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Ablation;Accounting;Afferent Neurons;American;Animal Model;Anogenital region;antinociception;Autoimmune;Bacteria;Behavioral;Biological Assay;Calcium;Categories;CD4 Positive T Lymphocytes;Cells;Central Nervous System;chronic pain;chronic pelvic pain;Chronic Prostatitis;Clinical;commensal bacteria;Cre lox recombination system;Development;Disease;Dynorphins;Dysuria;effective therapy;Electrophysiology (science);endogenous opioids;Future;Gene Expression;Goals;Grant;Human;Human Volunteers;Immune;Immune response;Immunofluorescence Immunologic;immunoregulation;In Vitro;Interleukin-10;kappa opioid receptors;Kinetics;Knock-out;Knockout Mice;Ligands;lipoteichoic acid;Mechanics;Mediating;Medical;men;Modeling;Morbidity - disease rate;mouse model;mRNA Expression;Mus;neuronal excitability;Neurons;neuroregulation;Nociception;Nociceptors;novel;Opioid Peptide;Outpatients;Pain;Pain management;Pain Measurement;Pathogenicity;Pathway interactions;Patients;Pelvic Pain;penis;Peptide Initiation Factors;Peripheral Nervous System;Phosphorylation;Positioning Attribute;preference;Primary Care Physician;prodynorphin;programmed cell death ligand 1;programmed cell death protein 1;Prostate;prostatitis;PTPN6 gene;receptor;receptor function;Receptor Gene;response;Role;Signal Transduction;Slice;Source;Spinal Ganglia;spontaneous pain;Staphylococcus epidermidis;Syndrome;System;Testis;Therapeutic;TLR2 gene;United States;Visit

PROJECT_TITLE: Lipoteichoic acid mediated modulation of chronic pain

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE This project will collect samples from 10,000 South Korean women with recurrent major depressive disorder and 10,000 matched controls. All subjects will be genotyped and the location of genetic risk factors identified in a genome-wide association analysis. The cohort will also provide detailed information about the likely environmental causes of depression, and when combined with a similarly deeply phenotyped cohort from China, will form a uniquely powerful resource for the discovery of genes involved in recurrent major depressive disorder.

PI_NAMEs: AHN, YONG MIN ;FLINT, JONATHAN  (contact);KENDLER, KENNETH SEEDMAN

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Address;Adult;African American;Age;Alcohol abuse;Anxiety Disorders;Bayesian Method;biobank;Biological;Bipolar Disorder;Calendar;causal variant;Characteristics;Child Abuse;China;Chinese;Chromosome Mapping;Clinical;cognitive change;cohort;Collaborations;Collection;comorbidity;Data;Data Set;depressive symptoms;Detection;Diagnosis;disability;Disease;disease heterogeneity;DNA;Drug abuse;East Asian;Environment;Environmental Exposure;Environmental Risk Factor;ethnic diversity;Ethnic Origin;European;Exclusion Criteria;experience;Failure;Far East;gene discovery;Genes;Genetic;genetic approach;genetic architecture;Genetic Research;genetic risk factor;Genetic study;Genetic Variation;genome wide association study;genomic locus;Genotype;grandparent;Haplotypes;Heterogeneity;Hispanic;Hospitals;improved;inclusion criteria;Individual;International;Interview;Interviewer;Joints;Korea;Koreans;life history;Linear Models;Linkage Disequilibrium;Location;Major Depressive Disorder;Maps;Measures;Mental Depression;Mental disorders;Mental Retardation;Meta-Analysis;Moods;multi-ethnic;National Institute of Mental Health;negative affect;non-affective psychoses;novel;Outcome;Pathogenesis;Pathway interactions;Patient Self-Report;Pattern;Phenotype;phenotypic data;Population;Population Heterogeneity;precision medicine;Predisposition;programs;psychiatric genomics;psychogenetics;rare variant;Recording of previous events;recruit;Recurrence;Reduce health disparities;Reporting;Research Personnel;Resources;response;Risk Factors;risk variant;sample collection;Sampling;Schedule;sex;Signal Transduction;Social support;Source;South Korea;Stressful Event;Structure;Subgroup;success;Tablets;Training;United States;Variant;Veterans;whole genome;Woman

PROJECT_TITLE: Identifying the genetic causes of depression in a deeply phenotyped population from South Korea


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Sleep Research

ORG_CITY: IOWA CITY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The relatively high proportion of active (REM) sleep in fetuses and newborns is the foundation for the decades-old hypothesis that active sleep is important for early brain development. One of the critical components of active sleep, myoclonic twitching, is now known to provide abundant and precise sensory input to the developing brain, suggesting that twitches are a key driver of activity-dependent development in the sensorimotor system. Here, using a longitudinal design to investigate sleep in premature human infants—who are at greater risk for cerebral palsy, autism, and other neurodevelopmental disorders—before and after discharge from the neonatal intensive care unit, we will determine whether twitching is a useful diagnostic tool for detecting atypical developmental trajectories and informing future interventions.

PI_NAMEs: BLUMBERG, MARK SAMUEL (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 2 year old;Age;Age Months;Attention;autism spectrum disorder;Behavior;behavior measurement;Behavioral;biobehavior;Brain;Brain Stem;Cerebellum;Cerebral Palsy;Clinical;Cognitive;Communities;Complex;Data;Data Set;density;Development;diagnostic tool;Electroencephalography;Exhibits;extreme prematurity;Eye;Face;Family;fetal;Fetal Movement;Fetus;follow up assessment;Foundations;Functional disorder;Funding;Future;Heart Rate;Hippocampus;Hour;Human;Infant;innovation;Intervention;Investigation;Iowa;laboratory development;Life;limb movement;Limb structure;Link;longitudinal design;Longitudinal Studies;Mediating;member;Motor Skills;Muscle;National Institute of Child Health and Human Development;Neonatal Intensive Care Units;neural correlate;neurobehavioral;Neurodevelopmental Disorder;Newborn Infant;Outcome;Pattern;Pediatric Hospitals;Phase;Physiological;Play;postnatal;postnatal development;Premature Birth;Premature Infant;rapid eye movement;Rattus;recruit;Research;Respiration;respiratory;Risk;Role;Scientist;sensorimotor system;Sensory;sensory feedback;sensory input;Sleep;sleep behavior;spatiotemporal;Spinal Cord;Strategic Planning;Survival Rate;Term Birth;Testing;Thalamic structure;theories;Time;ultrasound;Universities

PROJECT_TITLE: Sleep-related behavior and cortical activity in premature human infants as predictors of developmental outcomes.

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: NARRATIVE COURSE ON ADVANCED SEQUENCING TECHNOLOGIES & BIOINFORMATICS ANALYSIS  This advanced course offers the latest training in DNA and RNA sequencing and analysis. The explosion in genomics over the past several decades has spawned a range of sequencing technologies and approaches that each have advantages and disadvantages over competing approaches, even as the underlying cost drops precipitously. Biomedical scientists now use DNA sequencing technologies not just to catalog the genomes of thousands of species, but to probe genetic variation within species, including multicellular organisms such as plants and animals, fungi, bacteria and viruses. Techniques such as single cell sequencing allow for sampling of normal tissue across time and space, providing an ever more in-depth understanding of normal development and disease progression, while RNA sequencing in its many iterations provides detailed molecular analysis of the genome expression and regulation, informing both our understanding of normal biological processes and the progression of diseases such as cancer and viral infections. The plethora of sequencing technologies together produce an avalanche data, and practitioners must also be trained in the latest bioinformatics tools and approaches to make sense of and interpret the unprecedented volumes of information generated experimentally. The course will enroll a diverse cadre of students ranging from graduate students to group leaders, promoting collaboration and exchange of ideas between faculty and trainees, and thus represents a significant and valuable investment towards accelerating genome research and its application to biomedical and biological questions. Effort will be made to broaden access to this educational resource using a combination of hands-on in-person and online training.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Academic support;Acceleration;Address;Animals;Area;Attention;Bacteria;Base Sequence;beneficiary;Bioinformatics;bioinformatics pipeline;bioinformatics tool;Biological;Biological Process;Biology;biomedical scientist;Catalogs;Cells;Cloud Computing;cohort;Collaborations;Communicable Diseases;Communities;Complex;computerized data processing;cost;Coupled;Course Content;Data;Data Analyses;data visualization;Dedications;design;Development;digital;Disadvantaged;Disease Progression;DNA Resequencing;DNA sequencing;Drops;E-learning;Education;education resources;Educational Materials;Educational process of instructing;Enrollment;Evolution;Exercise;experience;Explosion;Faculty;file format;follow-up;fungus;Future;Generations;Genetic Variation;Genome;genome analysis;Genomics;graduate student;High-Throughput Nucleotide Sequencing;Immune response;improved;Individual;innovation;Instruction;instructor;interest;Investments;Laboratories;laboratory curriculum;laboratory experience;laboratory experiment;Language;large scale data;Learning;learning materials;lecturer;lectures;Libraries;Malignant Neoplasms;Massive Parallel Sequencing;Medicine;Mentors;Methods;Minority Groups;Modernization;Molecular Analysis;next generation sequencing;Normal tissue morphology;Nucleic acid sequencing;Occupations;Oncogenes;operation;Organism;outreach;Participant;personalized approach;Persons;Physiology;Plants;Postdoctoral Fellow;Problem Sets;Procedures;programs;Regulation;Research;Research Personnel;Running;Sampling;Science;Sequence Analysis;sequencing platform;Series;single cell sequencing;Standardization;student training;Students;Talents;teaching assistant;Techniques;Technology;Time;timeline;tool;Training;transcriptome sequencing;transcriptomic profiling;Twin Multiple Birth;Underrepresented Minority;underserved community;Underserved Population;United States;Update;Variant;virtual;Virus;Virus Diseases

PROJECT_TITLE: CSHL Course on Advanced Sequencing Technologies & Bioinformatics Analysis

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Aging;Prevention;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because a majority of women and men will experience lower urinary tract symptoms in their lifetime, but existing treatments have limited efficacy and important risks. Understanding new age-related mechanisms of lower urinary tract symptoms will lead to more accurate diagnosis and novel individualized treatments that improve or maintain health-related quality of life and physical function in older adults. Thus, the proposed research is relevant to the NIA's strategic goal to understand the dynamics of the aging process and to improve the health, well-being, and independence of older adults.

PI_NAMEs: BAUER, SCOTT RYAN (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: accurate diagnosis;Address;Adult;Age;age related;age related biomarkers;age related changes;age related decline;Aging;aging biomarker;aging mechanism;aging process;Ancillary Study;associated symptom;Bioenergetics;Biological;Biological Markers;biomarker identification;Bladder;Caring;Cessation of life;Chronology;Clinical;cohort;Creatine;Data;Denervation;Development;Diagnosis;effective intervention;Epidemiology;epidemiology study;Etiology;experience;fall risk;falls;Female;Fracture;Frail Elderly;frailty;Frequencies;Functional disorder;Functional impairment;Funding;Gait speed;Genitourinary system;Geroscience;Goals;Hand Strength;Health;health related quality of life;human old age (65+);Impairment;improved;Incontinence;individualized medicine;innovation;Intervention;Knowledge;Lead;Leg;levator ani muscle;lower urinary tract symptoms;male;Measurement;Measures;men;Mitochondria;Mobility decline;modifiable risk;mortality;multiple chronic conditions;Muscle;muscle form;Muscle function;Muscle Mitochondria;National Institute of Diabetes and Digestive and Kidney Diseases;Nocturia;novel;older adult;older men;older women;Organ;Outcome;oxidative damage;Pathology;Pelvic Floor Muscle;Pelvic floor structure;Pelvis;Personal Satisfaction;Phenotype;Physical assessment;Physical Function;Physical Performance;Practice Guidelines;prevent;Prospective cohort;Prospective, cohort study;prostate enlargement;Public Health;quadriceps muscle;Quality of life;reduced muscle mass;Research;Respiration;respiratory;Risk;Risk Factors;risk/benefit ratio;Role;Science;Severities;sex;Shapes;Skeletal Muscle;Stream;Symptoms;Syndrome;System;Testing;Thigh structure;Time;tool;United States National Institutes of Health;Urinary tract;Urine;Urodynamics;urogenital tract;Vertebral column;walking speed;Woman

PROJECT_TITLE: Age-related changes in skeletal muscle and lower urinary tract symptoms in older adults


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Lung;Organ Transplantation;Patient Safety;Precision Medicine;Transplantation

PHR: PROJECT NARRATIVE Mycophenolic acid, the current anti-proliferative immunosuppression agent of choice for lung transplant recipients, demonstrates extensive variability in both therapeutic effect and adverse drug effects. This project will investigate how genetic and clinical factors regulate mycophenolic acid exposure and effects and how mycophenolic acid exposure correlates with clinical outcomes. We aim to establish recommendations for therapeutic drug monitoring and precision dosing utilizing a patient’s genetic and clinical profile to optimize therapeutic effects and minimize adverse drug effects of mycophenolic acid.

PI_NAMEs: TAGUE, LANESHIA K (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute;Adaptive Immune System;Adverse drug effect;Adverse effects;Adverse event;adverse outcome;Affect;Algorithms;allograft rejection;Allografting;Anions;antiproliferative agents;Area Under Curve;Award;Bioinformatics;career development;Cell Physiology;Chronic;Clinical;Clinical Data;clinical effect;clinical implementation;clinical investigation;Clinical Management;clinical practice;Clinical Trials;cohort;Communication;conventional dosing;cytopenia;cytotoxicity;Data;Development;Development Plans;Dose;drug efficacy;Drug Kinetics;Drug Monitoring;evidence base;Family;Functional disorder;Funding;Future;Gene Expression;Genes;Genetic;genetic epidemiology;Genetic Medicine;Genetic Polymorphism;Genetic Predisposition to Disease;genome wide association study;Goals;Graft Survival;Grant;Granulopoiesis;healthy volunteer;Heritability;Hour;Immune;immune activation;Immune Tolerance;immunogenic;Immunologic Surveillance;Immunosuppression;Immunosuppressive Agents;Impairment;improved;individual patient;Infection;Infrastructure;Innate Immune System;Life;Link;Lung;lung allograft;Lung Diseases;Lung Transplantation;Malignant Neoplasms;Master of Science;Measurement;Measures;Mentors;Metabolism;Methodology;Methods;Mycophenolic Acid;Neutropenia;neutrophil;Opportunistic Infections;organ transplant recipient;Organ Transplantation;Outcome;Patient-Focused Outcomes;Patients;Pharmacogenetics;Pharmacogenomics;Phenotype;polygenic risk score;precision medicine;preservation;Recommendation;Research;Research Personnel;Resources;response;Risk Assessment;Safety;Sampling;Secure;side effect;Single Nucleotide Polymorphism;Solid;solute;Stress;Tacrolimus;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Time;tool;Training;translational medicine;Transplant Recipients;Transplantation;Transplantation Immunology;Treatment Efficacy;Universities;Variant;Washington;Work

PROJECT_TITLE: Influence of Mycophenolic Acid Pharmacogenomics on Lung Transplant Outcomes


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Digestive Diseases;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Over 2/3 of adults in the USA are overweight or obese and there is currently a shortage of effective treatments to reduce the excessive food intake that leads to obesity. Novel and effective obesity prevention and treatment strategies are aided by basic science research identifying specific brain chemical systems that reduce food intake. A novel approach is taken here; we believe that more progress can be made towards obesity treatment and reducing associated health care costs if basic research were to focus on understanding neural and biological mechanisms through which learning and memory, reward, and environmental food cues interact to cause excessive feeding and obesity.

PI_NAMEs: KANOSKI, SCOTT EDWARD (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acetylcholine;Adult;afferent nerve;Appetite Stimulants;Appetitive Behavior;Association Learning;Basic Science;Behavioral;Behavioral Mechanisms;Biological;biological systems;Brain;Brain region;Brain Stem;Categories;Chemicals;Cholecystokinin;cholinergic;Cholinergic Receptors;Chronic;Cognitive;cognitive process;Consumption;Cues;Data;Desire for food;Development;Dorsal;Eating;effective therapy;energy balance;Energy Intake;Episodic memory;experience;experimental study;feeding;Feeding behaviors;Fiber;Food;Funding;gastrointestinal;Genetic Recombination;ghrelin;ghrelin receptor;gut-brain axis;Health Care Costs;hedonic;Hippocampus;Hormones;Hypothalamic structure;Image;improved;in vivo;Incentives;innovation;Intestines;knock-down;Lateral;Lateral Hypothalamic Area;Learning;Link;Maps;Medial;Mediating;Memory;Memory impairment;memory process;Methodology;motivated behavior;multimodality;neural;neural circuit;Neural Pathways;Neurobiology;Neurons;neuroregulation;Neurosciences;neurotransmission;novel;novel strategies;Nutrient;Obesity;obesity prevention;obesity treatment;Overweight;Pathway interactions;Photometry;Population;Prefrontal Cortex;Prevention strategy;Process;receptor binding;Receptor Signaling;reduced food intake;Research;response;Rewards;RNA Interference;Role;Satiation;sensor;Signal Transduction;social;Stimulus;Stomach;Synapses;System;Technology;treatment strategy;Vagus nerve structure;Viral

PROJECT_TITLE: Higher-Order Neural Control of Food Intake