ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Disorders of growth plate chondrocyte maturation impact the growth of the skeleton, resulting in a spectrum of diseases from skeletal dysplasia to extreme short stature. These diverse conditions underscore the importance of tight regulation to normal physiology, yet the genetic pathways involved are poorly understood. By identifying new functional genetic mediators of growth plate maturation, I hope to gain new insight into how these diseases develop and establish targets for the design of novel therapeutics.

PI_NAMEs: RENTHAL, NORA EDWARDS (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;Affect;arm;Automobile Driving;Biological Assay;Biology;Bone Development;Bone Growth;career;Cartilage;CD 200;Cell Line;Cell Maturation;cell type;Cells;Childhood;Chondrocytes;clinically relevant;CRISPR screen;Data;design;Disease;Epiphysial cartilage;experimental study;Family;Family member;Flow Cytometry;functional genomics;Future;Genes;Genetic;Genetic Determinism;Genetic Transcription;genome wide association study;genome wide screen;genome-wide;Growth;Growth and Development function;Growth Disorders;Guide RNA;Height;Human;human data;improved;in vitro Model;inhibitor;insight;Knock-out;Knowledge;Length;Libraries;Life Cycle Stages;Ligase;Limb structure;Link;Mediator;member;Mus;myocyte-specific enhancer-binding-factor 2C;novel therapeutics;Pathway interactions;Patients;Phenotype;Physiologic Ossification;Physiology;premature;Proteins;Proteome;Regulation;Research;Role;screening;single-cell RNA sequencing;skeletal;Skeletal Development;skeletal disorder;skeletal dysplasia;Skeleton;smoothened signaling pathway;STAT1 gene;Structure;Sumoylation Pathway;Syndrome;Testing;Therapeutic;transcription factor;Transcriptional Regulation;transcriptome;Translating

PROJECT_TITLE: Translating Human Height Genetics to Skeletal Biology by Functional Genomics of the Growth Plate

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Hearing Loss;Neurosciences;Rehabilitation

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative  People with both vision and hearing loss have increased difficulties in daily functioning. Very little attention has been paid to the rehabilitation challenges faced by this large and increasing population. This project will investigate the impact of combined vision and hearing loss on the difficulties of this group in spatial localization, that is, in the ability to determine the direction of sounds and sights of objects in the environment.

PI_NAMEs: XIONG, YINGZI  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Address;Age;Aging;aging population;American;Attention;Audiology;Auditory;Auditory Perception;Auditory system;binaural hearing;Blindness;Calibration;career;Confusion;Crowding;Cues;daily functioning;Diagnosis;Ear;Ensure;Environment;Evaluation;Event;experience;fovea centralis;Goals;Hearing;hearing impairment;Image;Impairment;improved;Individual;Knowledge;Laboratories;Life;Light;Measures;Mentors;Methods;Minnesota;Modeling;Modernization;multisensory;older adult;Older Population;Ophthalmology;Outcome;Pathology;Perception;Performance;Perimetry;Persons;Phase;Population;Prevalence;professor;Protocols documentation;Quality of life;rehabilitation strategy;Rehabilitation therapy;Research;Research Personnel;Residual state;Retina;Risk;Safety;Science;Self-Help Devices;Sensorineural Hearing Loss;Sensory;sensory input;sensory system;Side;social;Social Interaction;Social Mobility;sound;Sound Localization;Source;Space Perception;Techniques;tool;Training;Universities;Vision;vision rehabilitation;Vision research;vision science;Visual;Visual impairment;Visual System;Visuospatial;Weight;Work

PROJECT_TITLE: Dual Sensory Loss: Impact of Vision and Hearing Impairment on Spatial Localization

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: IRVINE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Public Health Relevance The proposed work aims to expand and unify our lab’s projects surrounding a rapid evolution system called OrthoRep, pioneered by my group over the past several years. Using OrthoRep, we will address a range of important problems in biomedical research. These include the engineering of enzymes to cheaply synthesize drugs and commodity chemicals, the creation of better gene therapy tools and therapeutic proteins, and the design of new technologies for studying developmental processes.

PI_NAMEs: LIU, CHANG C (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Acceleration;Address;Affinity;Amino Acyl-tRNA Synthetases;Animals;Antibodies;Automobile Driving;Biological;Biomedical Research;Cell Lineage;Chemicals;Collection;design;Development;Developmental Process;DNA biosynthesis;DNA-Directed DNA Polymerase;Drug resistance;drug synthesis;Engineering;Enzymes;Evolution;gene therapy;Generations;Genes;Genetic;Genetic Code;high reward;improved;in vivo;interest;invention;Mammalian Cell;Methods;Mutation;new technology;Plasmids;Proteins;public health relevance;Reagent;Science;System;technology platform;therapeutic protein;tool;Transfer RNA;Work;Yeasts

PROJECT_TITLE: Synthetic genetic systems for rapid biomolecular evolution in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Sexual minority women (SMW) are at disproportionately high risk of both sexual assault and its resulting adverse mental health sequelae, but we know little about the upstream social determinants that contribute to this mental health disparity. Guided by an innovative, theoretically-grounded intersectional model, we propose to conduct the first direct test of the association of geospatial climates (e.g., municipal and state policy, SMW community presence) with SMW’s lived experiences of minority stress and mental health following sexual assault recovery. Results will inform clinical interventions and public policy advocacy.

PI_NAMEs: DWORKIN, EMILY RAPHAEL (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Adolescent;Adult;Advocacy;Affect;Age;aged;Anxiety;assault;Attention;Bisexual;Black race;Censuses;Characteristics;cisgender;Climate;Clinical;Communities;critical period;Data;Data Set;demographics;Disclosure;Discrimination;Disease;Disparity;Environment;ethnic identity;Etiology;Exhibits;experience;Exposure to;Forcible intercourse;Frequencies;gender diverse;Gender Identity;Geography;health disparity;help-seeking behavior;Heterosexuals;high risk;High Risk Woman;homonegativity;Impairment;improved;Individual;Inequity;innovation;Intervention;Latinx;Laws;lens;Lesbian;Lesbian Gay Bisexual Transgender Queer;Lived experience;Location;marginalized population;Mediating;Mental Depression;mental development;Mental Health;Minority Groups;minority health disparity;minority stress;Modeling;multilevel analysis;Municipalities;novel;Participant;Patient Self-Report;Penetration;Perception;Policies;Politics;Population;Population Density;Post-Traumatic Stress Disorders;Prevalence;prevent;Process;prospective;prospective test;Public Health;Public Policy;Race;racial identity;racial minority;racism;Reaction;Recording of previous events;Recovery;recruit;Research;Risk;Role;Sampling;Services;Sex Orientation;sexual assault;sexual minority;sexual minority women;social determinants;Social Identification;social stigma;Stigmatization;substance use;Surveys;Survivors;Symptoms;Testing;Theoretical model;Time;Trauma;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Sexual Assault Recovery Among Sexual Minority Women: A Longitudinal, Multi-Level Study

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Mental Health;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative: The Somali American immigrant community has high risk for obesity, hypertension, metabolic syndrome and diabetes, all of which are frequent comorbidities of deficient sleep, including short sleep duration, obstructive sleep apnea, and insomnia. We plan to examine the likelihood, types and severity of disrupted sleep in Somali Americans, identify mechanisms that may be causing the sleep deficiency, and explore how the sleep problem may be leading to increases in daytime and night time blood pressure. These findings will address important knowledge gaps in understanding health and disease in Somali immigrants, and provide actionable insights to help in preventing any future epidemic of cardiovascular and metabolic disease in this relatively young population.

PI_NAMEs: SOMERS, VIREND K (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Address;Advisory Committees;Africa;African ancestry;Age;American;Amphetamines;Behavior;Behavioral;Biological;Biological Factors;Black Populations;Blood Pressure;blood pressure elevation;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Central obesity;Clinic;Communities;community advisory board;community based participatory research;community collaboration;community engagement;comorbidity;Consumption;contextual factors;Data;Diabetes Mellitus;Diagnosis;Disease;Dislocations;Drowsiness;Environmental Risk Factor;ethnic identity;experience;future epidemic;Genotype;Geography;Health;Health Disparities Research;health disparity;Health Priorities;High Prevalence;high risk;Hour;Hypertension;hypertensive;Immigrant;Immigrant community;Immigration;Individual;innovation;insight;interdisciplinary approach;Intervention;Knowledge;Language;Measures;Mediating;Mediator;Metabolic Diseases;Metabolic syndrome;Minnesota;Modeling;National Heart, Lung, and Blood Institute;National Institute on Minority Health and Health Disparities;Neighborhoods;obesity risk;Obstructive Sleep Apnea;Outcome;Participant;Pathway interactions;Patients;Physical activity;physical inactivity;Play;Polysomnography;poor sleep;Population;Positioning Attribute;prevent;Prevention;Process;protective factors;psychological distress;psychosocial;psychosocial stressors;Public Health;racism;recruit;Refugee Camp;Reporting;Research;Research Priority;resilience;Risk;Risk Factors;risk mitigation;Role;salt intake;screening;Services;Severities;sex;Sleep;sleep abnormalities;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleeplessness;social culture;Social Work;sociocultural determinant;socioeconomic disadvantage;Sodium Chloride;Stimulant;Strategic vision;Stress;Time;Translating;Visceral fat;volunteer;Wakefulness

PROJECT_TITLE: Disrupted Sleep in Somali Americans – Implications for Hypertension Risk

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Legionella pneumophila is an infectious bacterium that causes Legionnaire’s disease and remains a major cause of morbidity and mortality in the immunocompromised such as the elderly. Caspase-11 is a component of a process (non-canonical inflammasome) which allows clearance of Legionella by phagocytic cells called macrophages. How caspase-11 regulates a cascade of events leading to bacterial clearance and the molecules involved in this cascade will be investigated in this proposal.

PI_NAMEs: AMER, AMAL O (contact);SEVEAU, STEPHANIE M M

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: 3-Dimensional;Actins;antimicrobial;Autophagocytosis;Autophagosome;Bacteria;Cancer Patient;CASP1 gene;Caspase;Cell Death;Cell membrane;Cells;cofilin;Complex;Confocal Microscopy;Cytoskeleton;Data;depolymerization;Down-Regulation;Elderly;Eukaryotic Cell;Event;F-Actin;Gelsolin;Gram-Negative Bacteria;Growth;Human;Immune;Immunocompromised Host;In Vitro;in vivo;Individual;Infection;Inflammasome;Inflammatory;Interleukin-1 beta;Legionella;Legionella pneumophila;Legionnaires' Disease;Lysosomes;Macrophage;Mediating;migration;Molecular;Morbidity - disease rate;mortality;Mus;N-terminal;Natural Immunity;neutrophil;novel;older patient;Organelles;pathogen;pathogenic bacteria;Peptide Hydrolases;permissiveness;Phagocytes;Phenotype;Physiological;polymerization;Polymers;Process;Proteins;Proteomics;Publishing;Recombinants;Reporting;Resolution;response;Role;Site;Spectrometry, Mass, Secondary Ion;Techniques;Testing;Three-dimensional analysis;Time;transcriptome sequencing;Vacuole

PROJECT_TITLE: THE ROLE OF THE NON-CANONICAL INFLAMMASOME IN INNATE IMMUNITY

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Asthma;Burden of Illness;Cardiovascular;Chronic Obstructive Pulmonary Disease;Clinical Research;Contraception/Reproduction;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Lung;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Physical Activity;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE Increasing evidence suggests that early life and reproductive events, as well as exposures during pregnancy, may have long-term impacts cardiovascular and lung health of women and their children but most cohorts are not well equipped to support research addressing these questions. We propose to strengthen the shared infrastructure necessary to support research aimed at identifying intergenerational, reproductive and early life risk factors for CVD (CHD, stroke) and obstructive lung disease (COPD and asthma) in three cohorts – the Nurses’ Health Study II (NHS-II), the Growing Up Today Study (GUTS) and the Nurses’ Health Study 3 (NHS3) – by focusing in four areas: 1) the maximization of existing resources, 2) the collection of biological specimens and in-person measurements of blood pressure and anthropometric data, 3) the expansion of web-based mobile technology and “Big Data” capabilities for the cohorts, and 4) strengthening our capability for data sharing. The ability to combine biomarker data, state-of-the-art mobile high-resolution measures, and traditional epidemiologic risk factor data, collected across generations and throughout the life-course in three related cohorts will enable us and others to conduct powerful etiologic and translational research.

PI_NAMEs: CHAVARRO, JORGE EDUARDO (contact);MANSON, JOANN ELISABETH

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Adult Children;Affect;African American population;Age;Air Pollution;analytical tool;Anthropometry;Area;Asthma;attributable mortality;Behavioral;Big Data;biobank;Biological;Biological Markers;Biological Specimen Banks;Blood Pressure;built environment;cardiorespiratory fitness;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cellular Phone;Cessation of life;Characteristics;Child;Chronic Obstructive Pulmonary Disease;Clinical;cohort;Collection;Communities;Coronary heart disease;Data;Data Collection;data infrastructure;data repository;data resource;data sharing;Databases;Diet;digital phenotyping;Dimensions;Disease;disorder risk;DNA;Dyslipidemias;Educational Materials;Electronic cigarette;Environmental Exposure;Epidemiology;epidemiology study;Erythrocytes;ethnic minority;Etiology;Event;excessive weight gain;Exposure to;follow-up;Food;Food Access;frontier;Future;Generations;Genes;Geographic Distribution;Geographic Information Systems;Geography;Gestational Diabetes;Goals;Green space;Health;Health Care Costs;Heart Diseases;Hispanic Americans;Hypertension;Individual;Infrastructure;Infrastructure Activities;innovation;interest;intergenerational;Life;Life Cycle Stages;lifestyle factors;Link;Long term disability;Lung Diseases;lung health;Maintenance;Marijuana;Measurement;Measures;Medical History;Medical Records;men;Minority;mobile computing;Morbidity - disease rate;mortality;Mothers;novel;Nurses' Health Study;Obesity;Obstructive Lung Diseases;offspring;Online Systems;Participant;Periodicals;Persons;Physical activity;Plasma;Pregnancy;Pregnancy Complications;pregnancy disorder;Premature Birth;Process;Protocols documentation;Questionnaires;racial minority;Recording of previous events;Recreation;Reporting;reproductive;Research;Research Support;Resolution;Resources;Risk;Risk Factors;RNA;Rural Population;Sleep;Socioeconomic Status;spatiotemporal;Specimen;stool sample;Stroke;Technology;Temperature;Total Lung Capacity;Translational Research;United States;Update;Urine;Visualization software;Woman;Women's Health;Women's mortality

PROJECT_TITLE: Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic research


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: COLUMBIA

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PUBLIC HEALTH SIGNIFICANCE This study will contribute to public health knowledge of the effects of Medicaid MCO coverage and utilization management design on access to OUD treatment, and the effects of Medicaid enrollees’ OUD treatment receipt within MCOs on adverse outcomes, namely opioid-related emergency department visits, hospitalizations, and mortality. The study will provide tangible guidance to states and Medicaid MCO plans regarding how to best structure coverage and utilization management parameters to ensure appropriate and efficient access to opioid use disorder treatment.

PI_NAMEs: ANDREWS, CHRISTINA MARIE (contact);GROGAN, COLLEEN M.

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: access restrictions;acute care;Address;Adverse event;adverse outcome;Affect;American;Attention;Awareness;Caring;Cessation of life;Clinical;Contracts;COVID-19;Data;Data Set;design;Diagnosis;Drops;Emergency department visit;Ensure;Epidemic;evidence base;falls;FDA approved;Fee-for-Service Plans;Health;health care service utilization;health knowledge;Health Services Accessibility;Hospitalization;Improve Access;innovation;insight;Insurance Carriers;Investigation;Kentucky;knowledge base;Link;longitudinal analysis;Managed Care;Medicaid;Medical;Methods;Monitor;mortality;New York;Ohio;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use disorder;Outcome;Overdose;Patients;Pharmaceutical Preparations;Policies;Policy Maker;Population;Positioning Attribute;Prevalence;prior authorization;programs;Public Health;Randomized;Recommendation;Recording of previous events;Regulation;relapse risk;Research;Risk Reduction;Selection Bias;Series;Specific qualifier value;Structure;Substance Use Disorder;Time;treatment services;trend;Virginia;Vulnerable Populations

PROJECT_TITLE: Medicaid Managed Care Coverage and Utilization Management of Opioid Use Disorder Treatment

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

ORG_CITY: PORTLAND

ORG_DEPT: DENTISTRY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Some of the most common oral diseases are typical examples of mucosal polymicrobial infections. This study will use oral bacteria as a model system to investigate how different species of the human flora can synergize to cause disease as well as identify potential mechanisms to inhibit this process.

PI_NAMEs: MERRITT, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Abscess;Antibiotic Therapy;Area;Bacteria;bacterial genetics;Biological Models;Clinical;clinically significant;Complex;Disease;Ecology;effective therapy;Etiology;Foundations;Fusobacterium;Genetic;Genetic study;Human;human microbiota;Infection;member;model organism;Mouth Diseases;Mucous Membrane;novel strategies;Oral;oral bacteria;Oral cavity;Pathogenesis;Pathogenicity;polymicrobial disease;Prevotella;Process;programs;Research;Role;Site;Streptococcus;Streptococcus anginosus;Streptococcus mutans;success;synergism;System;Virulence

PROJECT_TITLE: Advancing studies of polymicrobial diseases via streptococcal genetics


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emergency Care;Emerging Infectious Diseases;Health Services;Infectious Diseases;Kidney Disease;Patient Safety;Urologic Diseases;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative This pilot study will support the feasibility and safety of conducting a large multi-center randomized controlled trial comparing patient-directed antimicrobial treatment duration to a fixed indication-specific duration using an oral 3rd generation cephalosporin for outpatient treatment of women with acute uncomplicated pyelonephritis (AUP). Patients will discontinue therapy upon symptom resolution, which may result in less antibiotic exposure, fewer adverse events, and decreased promotion of antimicrobial resistance. This project potentially will have a significant impact on not only patients being treated for AUP but on how infectious diseases are treated generally, reversing a decades' old approach to prescription of antimicrobial therapy.

PI_NAMEs: FAINE, BRETT  (contact);TALAN, DAVID ANDREW

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Accident and Emergency department;Acute;Adverse event;adverse event risk;Affect;alternative treatment;Ambulatory Care;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Resistance;Area;arm;beta-Lactams;Binding;Cefixime;Cementation;Cephalosporins;Characteristics;Clinical;Clinical Data;Clinical Trials;combat;Communicable Diseases;Communities;Confidence Intervals;Consent;Data;Data Collection;effective therapy;Effectiveness;Eligibility Determination;Equilibrium;Escherichia coli;feasibility trial;fluoroquinolone resistance;Fluoroquinolones;Functional disorder;Generations;Goals;Guidelines;health organization;Home;improved;Individual;Infection;innovation;kidney infection;Location;mobile application;National Institute of Allergy and Infectious Disease;novel;novel strategies;Oral;Outcome;Outpatients;Participant;pathogen;Patient Discharge;patient oriented;Patient-Focused Outcomes;Patients;Performance;personalized approach;Physicians;pill;Pilot Projects;Prevalence;prevent;Randomized, Controlled Trials;Recommendation;Recurrence;recurrent infection;Regimen;Reporting;Research;Research Priority;Resistance;Resolution;Role;Safety;safety and feasibility;Serious Adverse Event;Societies;standard care;Symptoms;therapy duration;Time;tool;treatment duration;treatment guidelines;treatment response;trial comparing;Urinary tract infection;Vagina;Visit;Woman;women's treatment

PROJECT_TITLE: Personalized Antibiotic Therapy in the Emergency Department: PANTHER Trial

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Clinical Research;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: Project Narrative The current proposal aims to investigate the dynamics of burst-like β-frequency (15-29Hz) events in the human neural field potential in relation to both healthy and abnormal motor control. β-band activity is a key signature of both pathological and normal movement in humans, but recent high-impact work has shown that existing research mischaracterized the burst-like nature of this signal, casting doubt upon established relationships between β-activity and movement. This proposal aims to systematically investigate whether burst-like β-activity reflects specific inhibitory control functions in the human motor system, thereby motivating a novel, detailed, neurophysiologically grounded understanding of motor control in both health and disease.

PI_NAMEs: WESSEL, JAN R (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Affect;Animals;Applications Grants;Area;Basal Ganglia;Behavior;Brain;Cephalic;Clinical;cognitive control;Deep Brain Stimulation;Disease;Disease Marker;Disease Progression;Electroencephalography;Event;Frequencies;frontal lobe;Functional Magnetic Resonance Imaging;Future;Generations;Goals;Health;Human;Individual;interest;Investigation;Knowledge;Lesion;Link;Location;Maps;Measurement;Measures;Methods;Modeling;Motor;motor control;Motor Cortex;Movement;Movement Disorders;Nature;neural;neural circuit;neurophysiology;neurotransmission;novel;Parkinson Disease;Pathologic;Patients;Pattern;Phase;Physiological;Proactive Inhibition;Process;Reactive Inhibition;Research;Research Personnel;Resolution;Role;Signal Transduction;Site;spatiotemporal;Speed;Symptoms;System;Techniques;Testing;Theoretical model;Time;Uncertainty;Work

PROJECT_TITLE: The role of cortical and subcortical β-bursts in the cognitive control of human movement

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Narrative Atherosclerosis, obesity and non-alcoholic steatohepatitis (NASH) mediate increased risk for cardiovascular disease. This Program Project will probe the effects of caloric restriction, LXRα phosphorylation, Netrin1 and its receptor network and RAGE/DIAPH1 in these pathologies. The Program Project will discover mediating mechanisms and identify therapeutic targets for, ultimately, clinical trials in human patients.

PI_NAMEs: FISHER, EDWARD A (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Adipocytes;Adipose tissue;Adverse effects;Arterial Fatty Streak;Atherosclerosis;atherosclerosis risk;Binding;Biochemistry;Bioinformatics;Biological Availability;Biometry;Bone Marrow;Breeding;Caloric Restriction;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cell Communication;Cells;Clinical Trials;clinically significant;Communication;comorbidity;Complex;Cues;Cytoplasm;Databases;Deposition;Diabetes Mellitus;Employment;Endotoxins;experience;forging;Fostering;Functional disorder;Funding;High Fat Diet;Home;Human;human tissue;Immune;Immune response;imprint;in vivo;Infiltration;Inflammation;Inflammatory;inhibitor;insight;Insulin Resistance;Kupffer Cells;Lipids;Liver;LXRalpha protein;Macrophage;Mediating;Mediation;Mediator;Metabolic;Metabolic dysfunction;Metabolism;Molecular;Mus;Myelogenous;Nervous System;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;NTN1 gene;Obesity;Organ;Pathologic;Pathology;Patients;Pattern;Phosphorylation;Play;Procedures;Process;Program Research Project Grants;programs;receptor;recruit;Regulation;remediation;Resolution;response;Shapes;Signal Pathway;Site;Stimulus;Therapeutic;therapeutic target;Thermogenesis;Tissues;trafficking;transcription factor;transcriptome;Work

PROJECT_TITLE: Macrophage Dysfunction in Atherosclerosis and Cardiometabolic Diseases


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular

PROJECT_TITLE: Administrative, Biostatistics, Data Management, and Bioinformatics Core


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition

PI_NAMEs: MOORE, KATHRYN J (contact)

PROJECT_TERMS: Acceleration;Adipocytes;Adipose tissue;Advanced Glycosylation End Products;antigen detection;Antigens;Aorta;Apoptosis;Area;Arterial Fatty Streak;Atherosclerosis;Biochemical;Biochemistry;Biological Assay;Blood;Bone Marrow;Cardiometabolic Disease;cardiometabolism;cell type;Cells;Cholesterol;Circulation;Collagen;Cross-Sectional Studies;Crowns;Cultured Cells;Detection;dietary;Digestion;Ensure;fast protein liquid chromatography;Fatty acid glycerol esters;Fibrosis;Functional disorder;Gene Expression;Goals;Hepatic;High Density Lipoproteins;Histologic;Histology;Immune;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Label;Lipids;Liver;liver injury;Low-Density Lipoproteins;Macrophage;Measurement;Measures;Metabolic;Metabolic dysfunction;Monitor;monocyte;Morphology;Mus;Necrosis;non-alcoholic fatty liver disease;Obesity;Pathologic Processes;Pathology;Pathway interactions;Plasma;Population;Procedures;Productivity;programs;protein expression;Reproducibility;Scientist;Services;single nucleus RNA-sequencing;single-cell RNA sequencing;Sirius Red F3B;Stains;Standardization;stem;stem cells;Structure;Tissues;transcriptomics;Triglycerides;Very low density lipoprotein

PROJECT_TITLE: Pathology and Biochemistry Core


NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging;Cardiovascular;Digestive Diseases;Liver Disease;Transplantation

PI_NAMEs: SCHMIDT, ANN MARIE (contact)

PROJECT_TERMS: Adipose tissue;Age;Aorta;Atherosclerosis;Bone Marrow Transplantation;Breeding;Cardiometabolic Disease;Dual-Energy X-Ray Absorptiometry;extracellular vesicles;Functional disorder;Gender;Genotype;glucose tolerance;Hepatic Stellate Cell;Hepatocyte;imaging study;Individual;Insulin Resistance;irradiation;Kupffer Cells;Liver;Macrophage;Magnetic Resonance Imaging;member;Mus;Parabiosis;Partner in relationship;Procedures;programs;Quality Control;Randomized;Reproducibility;Scanning;Services;sex;Tail;Testing;Tissue Transplantation;Transplantation Surgery;ultrasound;Weaning

PROJECT_TITLE: Mouse Breeding and Procedure Core


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PROJECT_TERMS: Acceleration;Adipocytes;Adipose tissue;Adverse effects;Anti-Inflammatory Agents;Appearance;Arterial Fatty Streak;Atherosclerosis;Attenuated;attenuation;base;Bioinformatics;Body mass index;Body Weight decreased;Bone Marrow;Caloric Restriction;Cardiometabolic Disease;cardiometabolism;cardiovascular risk factor;cell type;Cells;Chromatin;Clinical;Clinical Research;clinically relevant;Collaborations;Communication;comorbidity;Conditioned Culture Media;Data;Data Set;Databases;Diet;dieting;Employment;Epidemic;Epigenetic Process;Event;extracellular vesicles;Fatty Liver;Fibrosis;Functional disorder;Funding;Genes;Goals;Hematopoietic;Hematopoietic stem cells;Hepatic;Hepatocyte;Histology;Homeostasis;Human;human data;human tissue;hypercholesterolemia;IgG Receptors;Immune;Immunohistochemistry;Immunologics;improved;In Vitro;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Insulin Resistance;interest;Interruption;Kupffer Cells;Liver;LXRalpha protein;Macrophage;Measures;Metabolic;Metabolic syndrome;Modeling;Molecular;Monitor;Mus;non-alcoholic;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Nuclear Hormone Receptors;Nuclear RNA;Obesity;Organ;Participant;Pathway interactions;patient stratification;Pattern;Phagocytes;Phosphorylation;Plasma;Prevalence;progenitor;programs;promoter;Proteomics;Reporting;Resolution;Risk;Risk Factors;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Site;stellate cell;stem;Testing;Therapeutic;Tissue Transplantation;Tissues;trafficking;Training;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Transplantation;Weight

PROJECT_TITLE: Resolving Macrophage Inflammation in Atherosclerotic Plaques and Other Sites in Insulin Resistance


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This proposed study aims to develop a high-throughput screening method to map noncoding functional elements important for regulation of alternative splicing. Disruption of these splicing-regulatory elements has been implicated in an expanding list of human genetic diseases and modulation of splicing has arisen as disease modifying therapeutics. Results from this study may provide tools and resources to better understand disease mechanisms and develop potential therapeutic interventions.

PI_NAMEs: ZHANG, CHAOLIN  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Affinity;Alternative Splicing;Antisense Oligonucleotides;Binding;Biological Assay;Cells;clinical sequencing;clinically actionable;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Color;Communities;Complex;deep sequencing;Directed Molecular Evolution;Disease;Distal;Dose;driving force;Elements;Eligibility Determination;Engineering;Enhancers;Epigenetic Process;Exons;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Diseases;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;Genomics;Genotype;Goals;Guide RNA;Health;high throughput screening;Human;human disease;Human Genetics;Human Genome;improved;Industry;interest;Intervention;Introns;Lentivirus;Libraries;Link;Malignant Neoplasms;Mammals;Maps;Medicine;Methods;Modality;Molecular;mRNA Precursor;Mus;mutant;Nervous System Disorder;novel;Pharmaceutical Preparations;Phenotype;Poison;Population;Protein Isoforms;Proteins;Quantitative Trait Loci;Regulation;Regulatory Element;Reporter;Research;Resolution;Resources;risk variant;RNA;RNA Binding;RNA library;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Role;single-cell RNA sequencing;Source;success;Technology;technology development;technology platform;Terminator Codon;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;tool;trait;Transcript;transcriptome;Translating;Untranslated RNA;Variant

PROJECT_TITLE: Mapping proximal and distal splicing-regulatory elements

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(02)M]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity

PROJECT_TERMS: Acceleration;Adipocytes;Adipose tissue;Antisense Oligonucleotides;Arterial Fatty Streak;Arteries;Atherosclerosis;atherosclerosis risk;Biogenesis;Bioinformatics;Blocking Antibodies;Cardiometabolic Disease;Cardiovascular Diseases;Cause of Death;CD4 Positive T Lymphocytes;Cell Communication;Cell Nucleus;Cell Physiology;Cells;Chronic;Communication;comorbidity;Complement 1q;Coupled;Cytoprotection;Cytoskeletal Modeling;Data;Databases;Deposition;Diabetes Mellitus;Diet;diet-induced obesity;Disease;Disease Progression;Environment;extracellular;Fatty Liver;Fibrosis;Fortification;Fostering;Functional disorder;Genetic;Genetic Models;Genetic Transcription;Glucans;Goals;High Fat Diet;Human;human tissue;Immune;Immune response;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Insulin Resistance;Intervention;lens;Link;lipid metabolism;Lipids;Liver;liver inflammation;Macrophage;Maps;Mediating;Messenger RNA;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Mitochondria;Molecular;Monoclonal Antibodies;mouse model;Mus;Myelogenous;Myeloid Cells;Myocardial Infarction;neogenin;Neuroimmune;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;NTN1 gene;Obesity;Organ;particle;Pathogenicity;Pathologic;Pathway interactions;Patients;Phenotype;Population;Process;Program Research Project Grants;programs;Proliferating;Protein Isoforms;receptor;recruit;Regulation;Resolution;response;Ribosomes;Role;Rupture;Shapes;Signal Transduction;single-cell RNA sequencing;Stimulus;T cell differentiation;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic evaluation;Tissue Expansion;Tissue Transplantation;Tissues;tool;trafficking;Training;transcriptome;transcriptome sequencing;transcriptomics;Translations;Up-Regulation;Visualization;Work

PROJECT_TITLE: Netrin-1 in Metabolic and Inflammatory Crosstalk in Cardiometabolic Disease


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Nutrition;Obesity

PROJECT_TERMS: Acceleration;Address;Adipocytes;Adipose tissue;antagonist;Antisense Oligonucleotides;Arterial Fatty Streak;Atherosclerosis;Binding;Bone Marrow;Cardiometabolic Disease;cardiometabolism;Cell Nucleus;Cells;Cholesterol;Communication;Complex;Coupled;Cues;cytokine;Cytoplasmic Tail;Databases;Diet;Encapsulated;Fat-Restricted Diet;Fatty Liver;Fibrosis;Fortification;Fructose;Functional disorder;Genes;Genetic Transcription;Glucans;Glucose;Hepatic;Hepatic Stellate Cell;Hepatocyte;High Fat Diet;Home;human tissue;Immune;Impairment;Infiltration;Inflammation;Insulin;Insulin Resistance;interferon regulatory factor-7;Kupffer Cells;lens;lipid metabolism;Lipids;Liver;Liver Fibrosis;Macrophage;Maps;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Molecular;Mus;Myelogenous;Myeloid Cells;Names;nonalcoholic steatohepatitis;novel;Obesity;Organ;Palmitates;particle;Pathogenesis;Plasma;programs;receptor for advanced glycation endproducts;recruit;Regulation;response;Role;Signal Pathway;Signal Transduction;Site;small molecule;Stimulus;synergism;Testing;Time;Tissues;trafficking;transcriptome;transcriptome sequencing;transcriptomics;Transplantation;Triglycerides;Up-Regulation;Visualization;western diet;Work

PROJECT_TITLE: RAGE, DIAPH1 and IRF7 and Macrophage Dysfunction in Atherosclerosis and Cardiometabolic Disease


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: State College

ORG_NAME: QUANTUMBIO, INC.

ORG_STATE: PA

PHR: Project Narrative: The successful completion of the SBIR grant will have a major impact on improving human health. It will improve the quality of protein structures, facilitate our understanding of biomolecular structure and function and will provide higher quality structural insights into protein/ligand (drug) interactions which will enhance our ability to rationally design novel therapeutics for human diseases.

PI_NAMEs: WESTERHOFF, LANCE M (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Acceleration;Active Sites;Address;Affinity;Binding;Binding Proteins;Binding Sites;Biological;Biological Sciences;case finding;Charge;Chemicals;Client;cloud based;Cloud Computing;cloud platform;Computational Biology;computational platform;cost;Coupled;Data;design;Development;Docking;Drug Design;drug discovery;Electrostatics;Event;flexibility;Free Energy;Grant;graph theory;graphical user interface;Health;Human;human disease;improved;Industrialization;Infrastructure;innovation;insight;interest;intermolecular interaction;KRAS2 gene;Laboratories;lead optimization;Letters;Libraries;Licensing;Life;Ligand Binding;Ligands;Link;Markov chain Monte Carlo methodology;Medicine;Methodology;Methods;Michigan;Modeling;Molecular;Molecular Conformation;molecular dynamics;Monte Carlo Method;Movement;next generation;novel;novel therapeutics;Perception;Pharmaceutical Preparations;Pharmaceutical Services;Pharmacologic Substance;Phase;Preparation;Printing;protein structure;Proteins;Protocols documentation;Publications;quantum;Quantum Mechanics;rational design;receptor;receptor binding;Reporting;Research;Sampling;Series;Small Business Innovation Research Grant;small molecule;Speed;Statistical Mechanics;Structure;System;Techniques;Technology;Time;tool;Universities;Update;Validation;validation studies;Variant;virtual machine;Work

PROJECT_TITLE: Research and cloud deployment of enhanced sampling methods in MovableType


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative Insight into gene regulatory mechanisms will be sought through studies of RNA polymerase pausing, transcription termination, translation control, and RNA binding proteins in Bacillus subtilis and Escherichia coli. Proper regulation of gene expression is of paramount importance for the function of cells in all organisms. As several human diseases arise in part through inappropriate gene expression, these studies will contribute to improving human health by providing a detailed mechanistic understanding of how genes are regulated.

PI_NAMEs: BABITZKE, PAUL L (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 5' Untranslated Regions;Affect;Bacillus subtilis;Bacteria;Binding Proteins;biological adaptation to stress;Cell Physiology;cell type;Chemicals;Collaborations;Comparative Study;Coupling;Cryoelectron Microscopy;DNA-Directed RNA Polymerase;Engineering;Escherichia coli;Event;flexibility;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Health;High temperature of physical object;Human;human disease;improved;in vivo;insight;Messenger RNA;Metabolic;metabolomics;Methods;Molecular;Open Reading Frames;Organism;Play;posttranscriptional;Process;programs;Proteins;Regulation;Regulon;Research;rho;Ribosomal Proteins;Ribosomes;RNA;RNA-Binding Proteins;Role;Signal Transduction;Site;Stress;Structure;System;termination factor;Testing;Transcription Initiation;transcription termination;Transcriptional Elongation Factors;transcriptome;Transfer RNA;Translations;Work

PROJECT_TITLE: Post-transcription Initiation Control of Gene Expression

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Mental Health;Mental Illness;Neurosciences;Prevention;Schizophrenia;Serious Mental Illness

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative Traditionally viewed as a brain disorder, it has become clear that one of the most devastating outcomes of schizophrenia spectrum disorder is its high rates of medical morbidity and mortality due to mostly age-related medical conditions like cardiovascular diseases. In parallel, accelerated brain aging is also evident. The proposed study is to determine to what extent aberrant vascular biology in schizophrenia may contribute to the earlier onset and more severe brain-body aging burden, which will guide the prevention and early intervention efforts for people suffered from schizophrenia.

PI_NAMEs: HONG, L ELLIOT ELLIOT (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: 3-Dimensional;Acceleration;Age;age acceleration;age effect;age group;age related;Aging;aging brain;aging related;aging related disease;allostatic load;Antipsychotic Agents;arterial spin labeling;arterial stiffness;Astrocytes;Autopsy;Biological Markers;Biology;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;Brain;Brain Diseases;Brain imaging;burden of illness;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cells;cerebrovascular;Cerebrovascular system;Cerebrum;comorbidity;Data;Diffusion;Disease;Early Intervention;early onset;Endothelial Cells;endothelial dysfunction;Endothelium;Functional disorder;General Population;Goals;gray matter;Guide prevention;Health;Health Services Accessibility;Homeostasis;Imaging Techniques;Impairment;insight;Investigation;Life;life span;Longitudinal cohort;longitudinal design;Measures;Mediating;Mediation;Medical;Metabolic syndrome;Methods;Modeling;Morbidity - disease rate;mortality;neuroimaging;novel;older adult;Outcome;Pathway interactions;Patients;Peripheral;Persons;Physiologic pulse;premature;Premature Mortality;Prevention;preventive intervention;reactive hyperemia;Reporting;Research;Risk Factors;Schizophrenia;schizophrenia spectrum disorder;screening;sex;Smoking;Stress;Stroke;System;Techniques;Testing;Time;Traumatic Brain Injury;vascular contributions;Water;white matter;white matter change;White Matter Disease;young adult

PROJECT_TITLE: The Vascular Axis in Schizophrenia Brain-Body Aging

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Data Science;Genetics;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Zebrafish as an animal model have greatly advanced toxicology and environmental studies, however, the lack of standards to report toxicological exposure and phenotypic outcomes impedes comparative studies. Here, we propose the creation of a new zebrafish toxicophenotype atlas consisting of images annotated with a zebrafish phenotype ontology standard and the exposures represented with a new toxicopheno data model. This community-driven standards initiative will engage diverse stakeholders in toxicology and environmental health sciences to ensure the relevance of and consensus on the newly created standards and atlas and their long-term sustainability.

PI_NAMEs: BURGER, ALEXA ;TORO, SABRINA  (contact)

PROGRAM_OFFICER_NAME: DUNCAN, CHRISTOPHER GENTRY

PROJECT_TERMS: Acceleration;Acute;Address;adverse outcome;Affect;Agreement;Animal Model;Atlases;Biological;Biological Assay;Breeding;Communities;community building;Community Developments;community engagement;comparative;Comparative Study;Consensus;Data;data access;data integration;data interoperability;data management;data modeling;data quality;data standards;data submission;design;Development;Documentation;Educational workshop;Ensure;Environmental Health;environmental toxicology;genetic manipulation;Genotype;Guidelines;Health;Human;Image;improved;interest;interoperability;Laboratories;Life;Link;Metadata;Methods;Modeling;Morphology;Ontology;Organism;Outcome;Pathway interactions;Phenotype;Policies;Process;programs;Protocols documentation;quality assurance;Reporting;Research;Resources;Retrieval;Sampling;Series;standardize guidelines;Structure;Testing;Time;tool;Toxic effect;toxicant;Toxicology;usability;Variant;Visual;web app;Work;Zebrafish

PROJECT_TITLE: Advancing a community-led zebrafish toxicology phenotype atlas

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-D (HS)]


ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE The human microbiome, which plays an important role in many diseases, is generally characterized using high-throughput genome sequencing. However, high-throughput sequencing offers noisy measurements of microbial systems. We will develop rigorous statistical methods and software for analyzing microbiome data, with the goal of improving the specificity and reproducibility of discoveries about the microbiome's influence on human health.

PI_NAMEs: WILLIS, AMY D (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Autoimmune Diseases;Biological;Cells;Communities;Complex;Computer software;cost;Data;Decision Making;Diagnosis;Disease;disease transmission;Ecology;Etiology;Evolution;Experimental Designs;Genetic;genome sequencing;Goals;Health;High-Throughput Nucleotide Sequencing;Human;human disease;Human Microbiome;improved;Infection;Malignant Neoplasms;Measurement;Metabolism;Methods;microbial;microbial community;microbiome;microbiome analysis;microbiome research;Modeling;Modernization;open source;Play;Recommendation;Reproducibility;Research;Research Personnel;Role;Sampling;Sexually Transmitted Diseases;Specificity;Statistical Methods;Structure;System;tool;Variant

PROJECT_TITLE: Statistical methods to enhance reproducible microbiome discovery

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Metabolism describes the processes required for life in biological systems. Understanding the specifies of metabolism is essential for progress in biomedical fields, for instance, facilitating rational drug design and understanding antibiotic resistance. Our work contributes new, fundamental knowledge about the nature and behavior of living systems by defining a biochemical activity and metabolic role for conserved proteins of unknown function, one of which is a disease marker in humans.

PI_NAMEs: DOWNS, DIANA M. (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Address;Antibiotic Resistance;Behavior;Biochemical;Biochemical Pathway;Biochemistry;Bioinformatics;Biological Markers;biological systems;Biology;cell injury;Chemicals;Complex;Disease;Disease Marker;Drug Design;environmental stressor;Epilepsy;Family;Family member;Genetic;Goals;Growth;Homologous Gene;Human;in vivo;insight;Knowledge;Laboratories;Life;member;Metabolic;Metabolic Diseases;Metabolic stress;Metabolism;metabolomics;Microbe;microbiome research;model organism;Molecular Biology;Molecular Genetics;Nature;network dysfunction;Organism;Pathogenesis;Pathogenicity;Process;Production;Prokaryotic Cells;Protein Family;Proteins;Proteomics;Pyridoxal Phosphate;Research;Role;Specific qualifier value;Stress;Structure;synthetic biology;System;Vision;Work

PROJECT_TITLE: Analysis of Metabolic Stress and Functional Integration in Prokaryotes


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Telehealth

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: NARRATIVE This R34 study has high Public Health significance, is complemented with rigor and scientific premise and uses a human-centered design, mixed methods and the ADAPT-ITT framework to address a critical gap in HIV/STI prevention-care. This study employs a 6-month pilot RCT to assess individual- and couple-level feasibility, acceptability and preliminary impact of a couples-based, digital health intervention (DHI) for improving HIV/STI prevention-care with a new population - Black heterosexual/opposite sex (BHOS) couples residing in New York State. It is expected that findings will reveal the feasibility, acceptability, and preliminary impact of the adapted DHI on couples’ primary (and secondary) sexual health outcomes, as well as how best to apply these findings in a larger, adequately powered trial (R01).

PI_NAMEs: LEBLANC, NATALIE MARIE (contact);MITCHELL, JASON W

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Address;Adherence;Adult;Agreement;AIDS prevention;arm;Awareness;Behavioral;Black Populations;Black race;Caring;cisgender;Cognitive;Communication;condoms;Couples;Data;Data Sources;Databases;design;Development;digital health;Education;eHealth;Enrollment;Evaluation;evidence base;Goals;health assessment;Health behavior;Health behavior change;health communication;Health Resources;Heterosexuals;HIV;HIV Infections;HIV/STD;HIV/STI intervention;human centered design;Hybrids;improved;Individual;Infection;Instruction;Intervention;Interview;Joints;Language;Length;Life;male;male couples;Measurement;Measures;Methods;mHealth;Modality;Modeling;New York;Newly Diagnosed;novel;Online Systems;Outcome;Output;Persons;Pilot Projects;pilot test;pre-exposure prophylaxis;Predisposition;preventive intervention;primary outcome;Public Health;Random Allocation;Recommendation;Recording of previous events;Reporting;reproductive;Resources;retention rate;screening;secondary outcome;seroconversion;sex;Sexual Health;STI prevention;Subgroup;substance use;Tactile;theories;Time;touchscreen;transmission process;Unsafe Sex;uptake;usability;Viral Load result;web-based intervention;women's diagnosis

PROJECT_TITLE: Adaptation of a digital health HIV prevention intervention for Black heterosexual couples in New York State

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE We are studying the role of molecular motors in organization of the cytoskeleton and its dynamics using a several systems, including mammalian cultured cells and Drosophila tissues (ovaries, neurons, and trachea) in vivo and in vitro. We will address the question of how microtubules and motors define distribution of other components of the cell, how they perform the bulk transport of the cytoplasm and how the motors and microtubules transport intermediate filaments in mammalian cells. These data can be used for analysis of transport of molecular components in neurons, trachea, and female reproductive tract, while also providing an excellent experimental system to study fundamental questions in cell biology.

PI_NAMEs: GELFAND, VLADIMIR I (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Biological Models;Cell Polarity;Cells;Cellular biology;Cellular Structures;Cultured Cells;Cytoplasm;Cytoplasmic Structures;Cytoskeletal Filaments;Cytoskeletal Modeling;Data;Defect;Development;Drosophila genus;Dynein ATPase;egg;female reproductive tract;Generations;Goals;Human;In Vitro;in vivo;Intermediate Filaments;Interphase Cell;Kinesin;Mammalian Cell;Microtubules;Molecular Motors;Motor;Movement;Neurodegenerative Disorders;Neurons;Nurses;Oocytes;Ovary;polarized cell;Process;Role;Rotation;System;Tissues;Trachea;Transport Process;Work

PROJECT_TITLE: Microtubule motors, cytoskeletal organization and cell polarity

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE More work needs to be done to understand how innovative and integrated data science interventions (e.g., artificial intelligence (AI), and machine learning (ML)) can improve patient safety in the real clinical environment. Therefore, using a robust implementation framework we will develop, implement and evaluate the association between our innovative and integrated data science interventions and patient safety in radiation oncology settings.

PI_NAMEs: MARKS, LAWRENCE B;MAZUR, LUKASZ  (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Development and Assessment of Artificial Intelligence (AI)-Enhanced Pre-treatment Peer-review Process to Improve Patient Safety in Radiation Oncology

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases

PHR: PROJECT NARRATIVE Digestive diseases have a major impact on health in the United States. This training program takes advantage of considerable resources in epidemiology and outcomes research at the University of North Carolina. The goal is to provide comprehensive training for individuals who will improve our understanding of the magnitude, etiology, impact and treatment of digestive diseases, and who will assume leadership roles in GI epidemiology and outcomes research.

PI_NAMEs: SANDLER, ROBERT S. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Digestive System Disorders;Epidemiology;Training Programs

PROJECT_TITLE: Digestive Disease Epidemiology Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-W (J1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Mental Health;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Lapses from HIV care are one of the most enduring challenges to HIV programs globally, and are associated with high rates of viremia and overall morbidity and mortality. The proposed research seeks to identify person- centered strategies using combinations of navigation and community-based medication delivery to both facilitate return to HIV care as well as sustain long-term reengagement post-return among individuals with treatment lapses in Zambia. This proposal advances a high priority research agenda to identify the most effective and efficient strategies for improving reengagement in care, and will help maximize not only the public health impact of HIV programs but will also advance strategies to improve care delivery for chronic diseases worldwide.

PI_NAMEs: MODY, AALOKE  (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Address;Adoption;Africa;Aftercare;Appointment;Appointments and Schedules;Back;barrier to care;care coordination;care delivery;care preference;Caring;Chronic Disease;Clinic;Clinical;Collaborations;Communities;cost;cost effectiveness;cost estimate;Counseling;Data;Data Collection;Effectiveness;effectiveness evaluation;Environment and Public Health;Evaluation;evidence base;experience;flexibility;Focus Groups;Health Personnel;Heterogeneity;HIV;Hospitalization;implementation evaluation;implementation outcomes;improved;improved outcome;Individual;Infectious Diseases Research;Interruption;Interview;Joints;Leadership;Long-Term Care;Methods;Morbidity - disease rate;mortality;Outcome;Outcome Study;outreach;Participant;person centered;Persons;Pharmaceutical Preparations;Pharmacy facility;Policies;prevent;primary outcome;process evaluation;Proctor framework;programs;psychosocial;Psychosocial Assessment and Care;Public Health;Randomized;Recording of previous events;Research;Research Priority;Resources;response;routine care;Sequential Multiple Assignment Randomized Trial;Services;sociodemographics;standard of care;success;Telephone;Time;time use;Travel;treatment effect;trial design;Universities;Viral;Viremia;Visit;Washington;Zambia

PROJECT_TITLE: Sequential Strategies to Reach and Reengage Individuals after Lapses from HIV Care in Zambia

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: Los Angeles

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative GPCR-mediated signaling pathways play a key role in all physiological systems as well as pathophysiological conditions including cancer, immune disorders, cardiovascular diseases, metabolic disorders (e.g. obesity, diabetes), pain and addiction. Over 30% of all prescription drugs on the market act via these receptors. The structural biology study of the human GPCR family will result in developing a deeper and thorough understanding of molecular mechanisms of ligand recognition and receptor function, which should translate into development of more efficient therapeutics with diminished side effects.

PI_NAMEs: CHEREZOV, VADIM  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Acceleration;addiction;beta-arrestin;Binding Sites;Biochemical;Biophysics;Cardiovascular Diseases;Cell membrane;Complex;Computers;Data;design;Development;Diabetes Mellitus;Drug Prescriptions;Drug Targeting;experimental study;Family;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;Human;Human Genome;Immune System Diseases;improved;insight;Laboratories;Ligands;Malignant Neoplasms;Marketing;Membrane;Membrane Proteins;Metabolic Diseases;Modeling;Molecular;Molecular Mechanisms of Action;novel;novel therapeutics;Obesity;Pain;Physiological;Play;programs;Proteins;receptor;receptor function;receptor-mediated signaling;Research;Resolution;side effect;Signal Pathway;Signal Transduction;Specificity;structural biology;Structure;System;technology development;Therapeutic;three dimensional structure;tool;Translating;transmission process

PROJECT_TITLE: Structural Biology Of G Protein-Coupled Receptors

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: PS

IC_NAME: NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STD AND TB PREVENTION

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Gaps between human immunodeficiency virus (HIV) infection evidence-based interventions and practice in the HIV neutral continuum of care, which are deepened in the US South, highlight the need for implementation research in this region in order to achieve US Ending the HIV Epidemic (EHE) goals. Thus, our overarching goal is to support and evaluate the implementation of a sustainable HIV health service model for rapid HIV testing and linkage to HIV treatment (ART) or prevention (PrEP) in Nashville, Tennessee (TN) and Memphis, Tennessee (TN), a southern US city which ranks 4th among all US Metropolitan Statistical Areas for HIV incidence. The results will inform future scaling of these models to additional HIV testing, care, and prevention sites across TN, a geographic area at the epicenter of important US HIV disparities as well as support the local Nashville and Memphis communities in reaching their established EHE goals.

PI_NAMEs: AUDET, CAROLYN ;PETTIT, APRIL  (contact);REILLY, MEREDITH

PROJECT_TITLE: Implementation of Rapid HIV Testing and Linkage to HIV Treatment or Prevention Among Vulnerable Populations in Tennessee


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Palliative Care;Prevention;Primary Health Care;Rehabilitation

PHR: Project Narrative: Almost 50% of cancer survivors will be 75 years or over by 2040, and the numbers of older survivors and caregivers are expected to grow with the aging of the population. Older cancer survivors experience physical and cognitive function impairments from curative-intent chemotherapy, yet no standard aging-sensitive intervention exists to improve outcomes. The overarching goal of this proposal is to evaluate whether a standardized Geriatric Evaluation and Management intervention (which surveils for the medical, physical, and psychological effects of chemotherapy to guide management recommendations including referrals to relevant disciplines) combined with a Survivorship Health Promotion program can improve outcomes of older survivors and their caregivers in the transition following curative-intent chemotherapy.

PI_NAMEs: JANELSINS, MICHELLE C;MOHILE, SUPRIYA G. (contact);MUSTIAN, KAREN M.

PROGRAM_OFFICER_NAME: MOLLICA, MICHELLE A

PROJECT_TERMS: Adult;Advocate;Aftercare;Age;age acceleration;aged;Aging;aging related;Appointment;arm;base;Behavioral;Biometry;Cancer Center;Cancer Patient;Cancer Survivor;cancer therapy;Caregivers;Caring;chemotherapy;Climate;Clinical Services;clinical trial enrollment;Clinical Trials;clinically relevant;clinically significant;Cluster randomized trial;Cognition;cognitive function;Collaborations;Communication;Communities;Community Clinical Oncology Program;comparative efficacy;Discipline;Discipline of Nursing;Distress;efficacious intervention;efficacy testing;Elderly;Emergency department visit;Ensure;Evaluation;experience;Fostering;functional outcomes;Geriatric Assessment;Geriatrics;Goals;health disparity;Health Promotion;Healthcare;Hospitalization;human old age (65+);Impaired cognition;Impairment;implementation science;improved;improved outcome;innovation;Intervention;Malignant Neoplasms;Medical;Modeling;multidisciplinary;National Cancer Institute;novel;older adult;older patient;Oncology;Outcome;Patients;Personal Satisfaction;Physical Function;physical impairment;Population;Primary Care;primary care provider;Principal Investigator;programs;Provider;provider communication;psychologic;psychosocial;Qualifying;Questionnaires;Randomized;Recommendation;recruit;Rehabilitation therapy;Reporting;Research;response;Sampling;satisfaction;Schedule;Solid Neoplasm;Standardization;Survivors;survivorship;Testing;Thermometers;Training;treatment as usual;Treatment/Psychosocial Effects;Triage;Universities;Walking

PROJECT_TITLE: Optimizing Functional Outcomes of Older Survivors After Chemotherapy


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cardiovascular;Clinical Research;Diabetes;Genetics;Nutrition;Obesity;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ORLANDO

ORG_NAME: ADVENTHEALTH ORLANDO

ORG_STATE: FL

PHR: Project Narrative The MoTrPAC ancillary project is a large-scale trial designed to determine the molecular transducers that are involved in the exercise response, particularly in skeletal muscle, and ultimately contribute to improved health status. The experiments proposed will examine the ability of resistance or aerobic exercise training to “imprint” skeletal muscle cells in a manner which confers long-term changes in this tissue, which in-turn contribute to improved metabolic health and functional capacity through epigenetic regulation of novel exercise response genes. The proposed work will also provide primary human skeletal muscle cells to the MoTrPAC repository for future use.

PI_NAMEs: HOUMARD, JOSEPH A;SPARKS, LAUREN MARIE (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Activities of Daily Living;Adipose tissue;Aerobic Exercise;Affect;Biopsy;Blood;Carbohydrates;Cell Culture Techniques;Cell model;cell repository;Cells;Characteristics;Consumption;Control Groups;Data;Daughter;DNA Integration;DNA Methylation;Epigenetic Process;epigenetic regulation;Exercise;exercise capacity;exercise prescription;exercise training;experimental study;Fatty Acids;Fiber;Funding;Future;Genes;genetic manipulation;Genetic Transcription;Glycogen;Goals;Health;Health Benefit;Health Status;Human;imprint;improved;In Vitro;in vitro Model;in vivo;Individual;insight;Insulin;insulin sensitivity;insulin signaling;Intervention;Investigation;Knowledge;lifestyle intervention;Link;Memory;Metabolic;Metabolic Diseases;Mission;Mitochondria;Modality;Modification;Molecular;Morbidity - disease rate;mortality;Muscle;Muscle Cells;Muscle Contraction;Muscle Fibers;Muscle Mitochondria;muscle progenitor cell;Muscle satellite cell;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;oxidation;parent project;Parents;Pathway interactions;Pattern;Physical activity;Population;Proliferating;Property;repository;Research Design;resistance exercise;response;Risk;Risk Factors;Risk Reduction;Sampling;segregation;self-renewal;Signal Transduction;Skeletal Muscle;skeletal muscle metabolism;skeletal muscle plasticity;stem cells;Testing;Tissue Banks;Tissues;Training;transcriptome sequencing;Transducers;trial design;United States National Institutes of Health;Work

PROJECT_TITLE: Investigating the effects of aerobic and resistance training in vivo on skeletal muscle metabolism in vitro in primary human muscle cells (MoTrMyo)


ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The microtubule network plays critical roles in organizing the environment within a cell. Although changes in microtubule function are associated with numerous human diseases, including neuropathies and cancer, we do not understand how molecular diversity at the level of the tubulin proteins that form microtubules gives rise to functional impacts at the cellular and tissue levels. This project uses a multi-system approach to define how the most molecularly diverse feature of tubulin proteins, the carboxy-terminal tail motifs, regulate microtubule function and tune network behavior.

PI_NAMEs: MOORE, JEFFREY KYLE (contact)

PROJECT_TERMS: Amino Acid Sequence;Behavior;Binding Proteins;Buffers;Cations;Cell Physiology;Cells;Cellular biology;Code;Complex;Cytoskeleton;Developmental Process;Disease;Environment;Genetic;Genetic Models;Goals;Heterogeneity;human disease;insight;Kinesin;Knowledge;Lead;live cell imaging;Malignant Neoplasms;Microtubules;Modeling;Molecular;Molecular Conformation;Motility;Motor;Neuropathy;novel;Play;Post-Translational Protein Processing;Protein Biochemistry;Proteins;Role;Set protein;Structure;Surface;System;Tail;Tissues;Tubulin

PROJECT_TITLE: Beyond the tubulin code: Understanding how subunit diversity regulates the formation and function of microtubules

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Aging;Biotechnology;Diabetes

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Type 2 diabetes (T2D), a major risk factor for poor bone quality and fractures, is associated with the premature accumulation of senescent cells and advanced glycation endproducts (AGEs; activators of the receptor for AGE [RAGE] pathway) in multiple tissues. Intuitively, senescent cells and RAGE could act independently or interact via cross-talk to contribute substantially to skeletal fragility and dysfunction of other systems and physiological processes in T2D, yet this concept has not been rigorously tested. In this proposal, we will test the hypothesis that targeting senescent cells and RAGE signaling in mice can alleviate or partially reverse T2D and its complications, including skeletal fragility.

PI_NAMEs: FARR, JOSHUA NICHOLAS (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Acceleration;Advanced Glycosylation End Products;Aging;Apoptosis;B-Lymphocytes;Biology;Biomechanics;bone;bone cell;bone quality;Bone remodeling;Bone Resorption;bone turnover;Brain;CASP8 gene;CDKN2A gene;Cell Aging;Cells;cellular targeting;Ceramides;clinical application;Collagen;Complications of Diabetes Mellitus;Cre-LoxP;Cytometry;Dasatinib;Data;Deterioration;Development;diabetic;Dominant Negative Receptor;Energy Metabolism;evidence base;Fatty acid glycerol esters;Fatty Acids;Fracture;Functional disorder;Genetic;Genetic Transcription;glycation;high dimensionality;Histologic;Hyperglycemia;improved;In Vitro;in vivo;Inflammation;Inflammatory;Innate Bone Remodeling;innovation;innovative technologies;insight;Intervention;Intuition;Life;Liver;LOX gene;Lysine;Maps;Marrow;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic dysfunction;Metabolic stress;Molecular;Mouse Strains;Mus;Myelogenous;Myeloid Cells;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutic intervention;old mice;Osteoblasts;Osteoclasts;Osteocytes;osteoprogenitor cell;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Physiological Processes;Population;pre-clinical;premature;prevent;Process;promoter;Property;Proteins;Quercetin;Receptor Activation;receptor binding;receptor for advanced glycation endproducts;Receptor Inhibition;Research;Resources;Risk Factors;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Serum;Signal Transduction;skeletal;Skeleton;Structure of beta Cell of islet;sugar;System;T-Lymphocyte;Technology;Testing;Therapeutic;Tissues;tool;Transgenes;Transgenic Mice;Transgenic Organisms;transgenic suicide gene;Translations;Work;young adult

PROJECT_TITLE: Targeting Cellular Senescence and RAGE in Type 2 Diabetes

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE: Traumatic brain injury (TBI) is a significant problem for U.S. Hispanic children; rehabilitation after TBI decrease disability, but requires timely initiation, and long treatments in hospitals, community healthcare facilities and schools. While parents play a critical role in their child’s recovery, Hispanic parents face substantial barriers that can result in delayed initiation of treatments and higher disability. Our study evaluates the effect of a culturally and linguistically tailored TBI education and navigation intervention, aimed to improve parental caregiving self-efficacy, optimize access and adherence to rehabilitation and ultimately improve outcomes in an underserved and rapidly growing population.

PI_NAMEs: JIMENEZ, NATHALIA  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: acceptability and feasibility;Acculturation;Acquired disability;Active Learning;Acute;Address;Adherence;Adolescent;Affect;Ambulatory Care;Anxiety;Appointment;Area;attentional control;bilingualism;Brain Injuries;care providers;caregiving;Caring;Cellular Phone;Central America;Child;Child Care;Childhood Injury;Cognitive;Communication;Communities;Community Healthcare;community organizations;comparison control;Control Groups;craniofacial;Data;Devices;disability;Education;education planning;education resources;Educational Status;Effectiveness;efficacy testing;Emotional;emotional functioning;Enrollment;Exclusion;Face;Family;flexibility;follow-up;functional gain;functional outcomes;functional status;Future;group intervention;Health care facility;health literacy;health related quality of life;Health Services;Healthcare;high risk population;Hispanic;Hispanic Populations;Hospitalization;Hospitals;Immigrant;Improve Access;improved;improved outcome;Income;Individual;Injury;Inpatients;Institution;Intervention;intervention effect;Knowledge;Linguistics;literacy;long-term rehabilitation;Measures;Mediator;Medicaid;Mental Depression;Mental Health;Mexico;Minority Groups;Modeling;neurosurgery;Not Hispanic or Latino;novel;Outcome;Outpatients;outreach;Pamphlets;Parents;Participant;Performance;Persons;Physical Function;pilot test;Play;Population;Population Growth;Populations at Risk;post intervention;primary caregiver;primary outcome;Problem Solving;programs;Proxy;Randomized;Randomized, Controlled Trials;Records;Recovery;Rehabilitation therapy;Reporting;Research;Risk;Risk Factors;Role;Schools;secondary outcome;Self Care;Self Efficacy;skills;social cognitive theory;social engagement;Spanish;TBI treatment;Testing;theories;therapy design;Time;Traumatic Brain Injury;treatment adherence;Uninsured;Work

PROJECT_TITLE: Brain Injury Outpatient Education and Care Navigation

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: The overall goal of this project is to bring to humans a novel radiotracer that measures the biochemistry of granzyme B, a serine protease that drives the pro-apoptotic effects of T cells. During the first phases of this project, the probe will be ushered into the clinic for a first in human study to determine safety, dosimetry, and pharmacokinetics. Subsequently, the accuracy of tracer detection of immunoresponsive tumors will be determined in a cohort of urothelial and renal cancer patients receiving standard of care immunomodulatory therapies.

PI_NAMEs: AGGARWAL, RAHUL ;CRAIK, CHARLES SCOTT;EVANS, MICHAEL JOHN (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Address;Adopted;anti-CTLA-4 therapy;anti-microbial peptide;anti-PD-1;anti-PD-1/PD-L1;Apoptotic;Aspartic Acid;Bacterial Infections;Biochemistry;Biological Markers;Biology;Biopsy;Blood;cancer imaging;Cancer Model;Cancer Patient;cancer therapy;Cell membrane;Cells;checkpoint inhibition;Chemistry;Clear cell renal cell carcinoma;Clinic;Clinical;Clinical Management;cohort;combat;CTLA4 gene;cytotoxicity;Data;Detection;Disease;dosimetry;Drug Kinetics;Enzymatic Biochemistry;enzyme activity;Enzymes;experience;Exposure to;extracellular;Family member;Female;first-in-human;Goals;Granzyme;HIV;Hour;Human;human imaging;human study;Image;imaging approach;imaging biomarker;Imaging technology;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immune system;immune-related adverse events;Immunologic Markers;immunological synapse;immunomodulatory therapies;in vivo;Infection;inhibitor;Injections;innovation;interest;Label;Length;male;Malignant neoplasm of urinary bladder;manufacture;Measurement;Measures;Mediating;Membrane;Modeling;Molecular Conformation;multidisciplinary;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;Patients;Peptide Hydrolases;Peptides;PET/CT scan;Phase;Phase 0 Study;phase 1 study;Phospholipids;Positron-Emission Tomography;pre-clinical;Productivity;programmed cell death ligand 1;Proteins;Qualifying;radiochemical;Radiolabeled;radiotracer;Rattus;Renal Carcinoma;Resistance;responders and non-responders;response;Risk;Rodent;Safety;SARS coronavirus;sensor;serial imaging;Serine Protease;Site;spatiotemporal;Specificity;Spleen;standard of care;success;T cell response;T-Cell Activation;T-Lymphocyte;Technology;Time;Toxic effect;Tracer;translational study;tumor;Tumor Tissue;uptake;Urothelial Cell;Urothelium;Viral;Virus Diseases;Work

PROJECT_TITLE: Precision targeting of T cell cytotoxicity with PET

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: This proposal is for a new training grant to support a well-established training program that integrates new approaches to make discoveries in lung disease, sleep and critical care. It will support the training of 6 postdoctoral fellows in various types of lung research from basic science to clinical trials. Using physiology as an integrator, individualized mentoring and team science are keys to building on our success at producing leaders in lung research with rich diversity and an ultimate goal of curing lung diseases.

PI_NAMEs: CROTTY ALEXANDER, LAURA ELISE;MALHOTRA, ATUL  (contact);SUN, XIN

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: next generation;respiratory;Science

PROJECT_TITLE: Developing a Diverse Next Generation of Leaders in Respiratory Science

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: TROY

ORG_DEPT: CHEMISTRY

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

PHR: PROJECT NARRATIVE Integral Membrane Proteins (IMPs) include many biomedically-important gate keepers, receptors, transporters, homeostasis regulators, and potential drug discovery targets. We are developing a robust and reproducible platform for accurate, reliable, validated, and reproducible structure determination of IMPs, and applying this platform for structure determination of IMPs selected from the genomes of NIH priority pathogens. We also propose to develop novel and robust methods for quantifying distributions of conformational states of proteins, and to apply these technologies in structure-dynamic-function studies of key proteins from pathogenic bacteria, g-retroviruses, influenza viruses, and coronaviruses.

PI_NAMEs: MONTELIONE, GAETANO T (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Affinity;Anti-viral Agents;Antibiotics;Attenuated Live Virus Vaccine;Binding;Biological Assay;Biology;biophysical chemistry;Communities;Complex;Coronavirus;cost effective;COVID-19 therapeutics;Data;design;Docking;drug discovery;Drug Targeting;Electrons;Environment;Enzyme Kinetics;Escherichia coli;FDA approved;flexibility;Fluorescence Resonance Energy Transfer;Genes;Genome;Hepatitis C virus;Homeostasis;Human;human pathogen;Hybrids;Influenza;influenza infection;influenzavirus;inhibitor therapy;Innate Immune Response;innovation;insight;Integral Membrane Protein;Integrase;Isotopes;Klebsiella pneumoniae;Lead;Mediating;Medical Research;Membrane;Methods;microorganism;Modeling;Molecular Conformation;Moloney Leukemia Virus;Nonstructural Protein;novel;novel therapeutics;pathogenic bacteria;Pathogenicity;Peptide Hydrolases;Pharmaceutical Preparations;Play;priority pathogen;Probability;programs;Protease Inhibitor;Protein Analysis;protein structure prediction;Proteins;Pseudomonas aeruginosa;receptor;reconstitution;Reproducibility;Research Project Summaries;Retroviridae;RNA;Roentgen Rays;Role;SARS-CoV-2 inhibitor;SH2D3C gene;Specificity;Spectrum Analysis;Structure;System;Technology;therapeutic development;United States National Institutes of Health;vaccine development;Viral;Virus;Virus Replication;X-Ray Crystallography

PROJECT_TITLE: Hybrid Methods for Dynamic Structure Analysis of Proteins from Pathogenic Microorganisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE Synucleinopathies, including Parkinson's disease, are progressive neurodegenerative diseases that affect thousands of people each year. It is imperative to study the flexible regions of α-synuclein, the misfolded protein associated with these diseases, as research has demonstrated that they influence disease severity. My findings will provide insight on the molecular features that will help us understand harmful cellular interactions and toxicity in misfolded α-synuclein.

PI_NAMEs: PACHECO, SAYURI  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Adopted;Affect;alpha synuclein;Alzheimer's Disease;Amino Acid Sequence;Amyloid beta-Protein;Amyloid Fibrils;Antibodies;beta pleated sheet;Binding;biophysical techniques;Brain;C-terminal;Cell Communication;Cell Culture Techniques;Complex;Data;Deposition;Disease;Electron Spin Resonance Spectroscopy;Fiber;fiber cell;flexibility;Future;Genetic Polymorphism;Huntington gene;In Vitro;insight;Length;Lewy Bodies;Ligands;Mediating;Methods;misfolded protein;Modeling;Molecular;Molecular Conformation;molecular dynamics;monomer;Morphology;Motion;Mutagenesis;Nature;Neurodegenerative Disorders;Neurons;neuropathology;Parkinson Disease;patient variability;Patients;Persons;Pharmaceutical Preparations;Play;Polymorph;preference;Property;protein aggregation;Proteins;Research;Residual state;Resolution;Role;Severity of illness;solid state nuclear magnetic resonance;Structure;Surface;synucleinopathy;tau Proteins;Testing;Therapeutic;Toxic effect;Toxicity Tests

PROJECT_TITLE: Identifying differences in dynamics and residual structure of intrinsically disordered domains between monomer and fibers: using alpha-synuclein as a model


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Cardiovascular;Cerebrovascular;Heart Disease;Hematology;Networking and Information Technology R&D (NITRD);Stroke

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: Cardiovascular devices that are implanted today carry a risk of un-intended blood clotting, which may cause serious injury including stroke and bleeding. The purpose of this project is to create a computer simulation program that will predict when this might occur, and thereby help doctors adjust dosage of blood-thinners, and guide developers of these devices to produce more safe and effective devices.

PI_NAMEs: ANTAKI, JAMES F. (contact);BUTCHER, JONATHAN TALBOT

PROGRAM_OFFICER_NAME: HSU, LI-YUEH

PROJECT_TITLE: Multiscale Model of Thrombosis in Artificial Circulation

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Digestive Diseases;Genetics;Human Genome

ORG_STATE: MN

PHR: PROJECT NARRATIVE/ LAY SUMMARY Diabetic gastroparesis is a complication of diabetes that causes the stomach to not empty well and as a result of our previous work we know that increased oxidative stress, loss of interstitial cells of Cajal, and changes to specialized immune cells called macrophages are the most common cellular abnormalities. We now focus on the mechanism by which diabetes changes a blood cell type called a monocyte that enters the stomach and becomes an activated macrophage, which disrupts stomach function by damaging interstitial cells of Cajal. This new understanding will permit us to develop therapies for gastroparesis that target these cells.

PI_NAMEs: FARRUGIA, GIANRICO  (contact);GROVER, MADHUSUDAN

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Affect;Anti-Inflammatory Agents;ATAC-seq;Biological;Blood Cells;cell injury;cell type;Cells;Complement;Complications of Diabetes Mellitus;cytokine;Cytometry;Data;Development;Diabetes Mellitus;diabetic;diabetic gastroparesis;Diabetic mouse;Disease;Enhancers;Environment;Epigenetic Process;epigenomics;Equilibrium;experimental study;Exposure to;Functional disorder;Gastric Emptying;gastrointestinal;Gastroparesis;Gene Expression;Genes;Genetic;Health;Immune;improved;Infiltration;Inflammation Mediators;Inflammatory;Interstitial Cell of Cajal;Knowledge;Macrophage;Metabolism;monocyte;Mononuclear;Mus;Obstruction;Oxidative Stress;paracrine;Patients;Phagocytes;Phenotype;Play;Positioning Attribute;preservation;Prevention;Proteins;response;Role;Signal Pathway;single-cell RNA sequencing;Solid;Source;Stomach;System;Techniques;Technology;Testing;therapy development;Tissues;Work

PROJECT_TITLE: Pathophysiology of Diabetic Gastroparesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


ORG_DEPT: PATHOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Reproductive disorders as well as contraception/family planning have major impacts on the health and well being of individuals and their children worldwide. This training program prepares young scientists to address these important problems at the level of basic and translational research and in research-related careers that require expertise in reproductive biology.

PI_NAMEs: PANGAS, STEPHANIE A. (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Reproductive Sciences

PROJECT_TITLE: Comprehensive Mechanisms in Reproductive Sciences


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Harvard Catalyst K12 Program will be the premier educational opportunity at Harvard Medical School and its associated academic medical centers for early-stage investigators seeking to pursue a career in clinical and translational research. The program will build off the already successful KL2 program, which launched in 2008. It will also embrace many new initiatives, including enriched mentoring, training in translational science, a strong and directed effort to pursue diversity and inclusivity at every level, and a range of new educational opportunities and experiences to ensure that the highly promising physician scientists of today can become the leading medical innovators of tomorrow.

PI_NAMEs: MILLER, KAREN K (contact)

PROGRAM_OFFICER_NAME: HARTSHORN, CHRISTOPHER

PROJECT_TERMS: Academic Medical Centers;Academy;career;career development;catalyst;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;Communities;community engagement;Competence;Dedications;Development;diversity and inclusion;educational atmosphere;Educational Curriculum;Elements;Ensure;Environment;Funding;Future;Goals;Growth;Health;Human;improved;Infrastructure;innovation;interdisciplinary collaboration;Leadership;Medical Research;medical schools;Mentored Clinical Scientist Development Program;Mentors;Mentorship;National Center for Advancing Translational Sciences;Performance;Program Development;programs;Research;Research Personnel;Scholars Program;Science;success;Time;Training;Translating;translational pipeline;Translational Research;translational scientist;United States National Institutes of Health;visiting scholar;Work

PROJECT_TITLE: CTSA K12 Program at Harvard Medical School


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

PHR: Project Narrative: Lung cancer is the leading global cause of cancer death but can be cured when treated with immunotherapy. Specific genetic changes may make lung cancer more vulnerable to immunotherapy. This work aims to understand susceptibility to immunotherapy in the 10% of lung adenocarcinomas that have one particular genetic change, which causes loss of the protein RBM10.

PI_NAMEs: MATHEY-ANDREWS, NICOLAS  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Adenocarcinoma;Advanced Malignant Neoplasm;Animals;anti-PD-1;anti-tumor immune response;Antibodies;Antigen Presentation;antigen-specific T cells;Antigens;Binding;Bioinformatics;Biological Markers;cancer cell;Cancer Etiology;cancer genome;cancer immunotherapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cessation of life;clinical predictors;cohort;Common Neoplasm;CRISPR/Cas technology;Development;Dose;driver mutation;Epitopes;Event;Exhibits;Genes;Genetically Engineered Mouse;Genome engineering;Genotype;Goals;Growth;Histologic;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immune response;Immune system;Immunocompetent;immunogenic;immunogenicity;Immunoprecipitation;Immunotherapy;in vivo Model;Infiltration;innovation;Knock-out;loss of function mutation;Lung;Lung Adenocarcinoma;Lung Neoplasms;Lymphocyte;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Methods;Modeling;mouse model;mRNA sequencing;mutant;Mutation;neoantigens;neoplastic cell;novel;novel therapeutics;patient stratification;patient subsets;Patients;Pattern;Peptide/MHC Complex;Peptides;predicting response;Predisposition;Productivity;programmed cell death ligand 1;Protein Fragment;Proteins;Publishing;Recurrence;research study;response;restraint;RNA Splicing;Role;Somatic Mutation;standard of care;Suppressor Mutations;T cell response;T-Cell Depletion;T-Lymphocyte;Testing;Transcript;transcriptome sequencing;Translating;Translations;tumor;Tumor Antigens;Tumor Burden;Tumor Immunity;Work

PROJECT_TITLE: Investigating splicing-derived antigens in the context of Rbm10-mutant lung adenocarcinoma


NIH_SPENDING_CATS: Obesity

ORG_CITY: KANSAS CITY

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE  Obesity and associated comorbid disease reduce quality of life and increase early mortality. The purpose of this T32 training grant is to prepare predoctoral students with translational, interdisciplinary research training, that will uniquely prepare them for an impactful career focused on obesity research.

PI_NAMEs: THYFAULT, JOHN P;WRIGHT, DOUGLAS E (contact)

PROJECT_TITLE: Translating Obesity, Metabolic Dysfunction and Comorbid Disease States

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  Neuromuscular regeneration remains challenging with unsatisfactory outcomes in clinical settings. To address this challenge, our multidisciplinary team will integrate the state-of-art technologies to develop miniaturized wireless devices that are bioresorbable and stretchable, which will be implanted for minimally invasive electrical stimulation to accelerate neuromuscular regeneration.

PI_NAMEs: LI, SONG  (contact);ROGERS, JOHN

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acceleration;Address;American;Atrophic;Autologous;Axon;axon growth;axon regeneration;axonal sprouting;bioelectronics;Clinical;Development;Devices;Distal;Drug Delivery Systems;Electric Stimulation;Electrodes;Goals;Growth;Healthcare;Implant;improved;injured;Injury;innovation;Medical;miniaturize;minimally invasive;multidisciplinary;multimodality;Muscle;muscle degeneration;Muscular Atrophy;Nanotechnology;Natural regeneration;Nerve;nerve injury;neuromuscular;Neuromuscular Junction;neuromuscular rehabilitation;Neurons;novel;novel strategies;Operative Surgical Procedures;Outcome;Patients;Peripheral;Peripheral nerve injury;Peripheral Nerves;Physical therapy;Physicians;Pilot Projects;point of care;Prevention;programs;Protocols documentation;Recovery of Function;Regenerative capacity;Regenerative engineering;Regenerative Medicine;regenerative therapy;reinnervation;repaired;Research Personnel;sciatic nerve;Stem cell transplant;synergism;System;Technology;Testing;Therapeutic;therapy outcome;Time;tissue regeneration;United States;wireless;wireless electronic;Work

PROJECT_TITLE: Multimodal wireless electrical stimulation for tissue regeneration

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE: OVERALL YALE ADRC  The Yale Alzheimer Disease Research Center seeks to advance our understanding of Alzheimer’s disease with the eventual goal of translating laboratory discoveries into novel effective clinical therapies. Seven Cores (Administrative, Clinical, Data, Biomarker, Neuropathology, Imaging and Outreach) and a Research Education Component will work together to achieve this goal. Our unifying theme is a focus on the cell biology of specific neurons, and its heterogenous disruption in Alzheimer’s disease.

PI_NAMEs: STRITTMATTER, STEPHEN M (contact);VAN DYCK, CHRISTOPHER H

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Acceleration;Advisory Committees;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Autopsy;Award;Axonal Transport;Back;Behavioral;bench to bedside;Biological;Biological Assay;Biological Markers;Blood Cells;Brain;brain tissue;career;career development;Career Mobility;Caregiver support;Cells;Cellular biology;Clinic;Clinical;clinical care;Clinical Data;Clinical Trials;cohort;Collaborations;Communities;Connecticut;Coupled;Data;Data Collection;data management;Data Set;Development;Dimensions;Disease;DNA;doctoral student;Education;Education and Outreach;education research;epigenomics;ethnic diversity;Evaluation;Faculty;Family;family burden;Fostering;Functional Magnetic Resonance Imaging;Funding;Future;Genome;Genomics;Gerontology;Goals;graduate student;Heterogeneity;Hospitals;human subject;human tissue;Image;Impaired cognition;Individual;induced pluripotent stem cell;Intention;Intervention;Investigation;kinase inhibitor;Knowledge;Laboratories;Laboratory Research;Leadership;Learning;Life;Ligands;Lysosomes;Maps;Mass Spectrum Analysis;Measures;member;Memory Disorders;Mentors;Mentorship;Methodology;Methods;Methylation;Minority;Modification;Molecular;Molecular Analysis;Monitor;Nerve Degeneration;Neurology;Neuronal Dysfunction;Neurons;neuropathology;Neuropsychology;Neurosciences;novel;Organelles;outreach;Pathologic;Pathway interactions;Pharmacology;Phase;Play;Population;Positron-Emission Tomography;Postdoctoral Fellow;postsynaptic;programs;Proteome;Recording of previous events;Records;recruit;repaired;Research;research and development;Research Personnel;Research Project Grants;research study;Research Support;Resources;Rest;Role;sample collection;Serum;Signal Transduction;Site;Specimen;statistics;success;Synapses;Testing;Therapeutic;therapeutic development;Tracer;Training;transcriptomics;Translating;Translational trial;Translations;United States National Institutes of Health;Vocational Guidance;Whole Blood;Work

PROJECT_TITLE: Yale Alzheimer Disease Research Center