NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Immunotherapy;Orphan Drug;Patient Safety;Pediatric;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Sickle cell disease (SCD), which arises from a missense mutation in the β-globin gene that causes polymerization of sickle hemoglobin (HbS), affects approximately 100,000 individuals in the United States and is associated with shortened life expectancy, with only 50% of patients surviving beyond their fifth decade. The use of hydroxyurea, newer second-line therapies, and chronic blood transfusion may alleviate some of the complications of SCD, but allogeneic hematopoietic cell transplantation (HCT) using a matched related donor is the only potential cure and is considered standard of care for patients with severe SCD. The proposed phase II clinical trial in adults and children with severe SCD will evaluate a pharmacologic immunosuppressive strategy prior to reduced toxicity myeloablative mismatched unrelated donor (MMUD) HCT, followed by post-transplant cyclophosphamide (PTCY)-based graft-versus-host disease (GvHD) prophylaxis, in order to mitigate risk of graft failure in a patient population at high risk for allograft rejection and treatment-related complications.

PI_NAMEs: PERALES, MIGUEL-ANGEL  (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Accreditation;Address;Adopted;Adult;Affect;Allogenic;allograft rejection;beta Globin;Blood;Blood Transfusion;Bone Marrow Transplantation;Busulfan;Cell Therapy;Child;Childhood;Chimerism;Chronic;Clinical;clinical center;Clinical Research;Clinical Trials Network;Comprehensive Cancer Center;Country;Coupled;Cyclophosphamide;Data;Dose;dose individualization;Drug Exposure;Drug Kinetics;Effector Cell;Engraftment;experience;fludarabine;follow-up;gene therapy;Genes;Goals;graft failure;graft vs host disease;Head;Hematologic Neoplasms;Hematological Disease;Hematology;Hematopoietic Stem Cell Transplantation;Hemoglobinopathies;high risk;HLA Antigens;hydroxyurea;Immune;Immunosuppression;improved;improved outcome;Individual;innovation;Leadership;Life;Life Expectancy;member;Memorial Sloan-Kettering Cancer Center;Missense Mutation;Mission;Modeling;Multi-Institutional Clinical Trial;Multicenter Trials;Non-Malignant;novel;novel therapeutics;Oncology;Oryctolagus cuniculus;Outcome;Patient Care;patient population;Patients;pharmacologic;Phase;phase 2 study;Phase II Clinical Trials;polymerization;Polymers;post-transplant;primary endpoint;programs;Prophylactic treatment;prospective;Protocols documentation;Regimen;Registries;Reporting;Research Personnel;Risk;risk mitigation;Scientist;Series;Services;Siblings;Sickle Cell Anemia;Sickle Hemoglobin;standard of care;Structure;success;Thalassemia;Therapeutic;Toxic effect;Transplantation;United States

PROJECT_TITLE: BMT Core - MSK


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Genomic diversity is a fundamental aspect of human natural history. Variations in susceptibility to complex diseases within the human population highlight the significance of understanding genomic diversity to uncover previously unknown mechanisms of common diseases risk. This proposal seeks to elucidate the contribution of human-specific genomic diversity to the regulation of cell fate commitment and the maintenance of cellular states across a spectrum of cell types.

PI_NAMEs: LO SARDO, VALENTINA  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Biological Assay;Biological Process;cell determination;Cell Fate Control;Cell Maintenance;Cell Physiology;cell type;Cells;Complex;Disease;Disease susceptibility;disorder risk;Ethnic Origin;Exhibits;functional genomics;Genetic;genetic risk factor;genetic variant;Genome;genome editing;genomic locus;Genomics;Goals;Haplotypes;Health;Human;human induced pluripotent stem cells;induced pluripotent stem cell;Laboratories;Light;Linkage Disequilibrium;Maintenance;Natural History;Physiological;Population;Predisposition;Recording of previous events;Research;response;Risk;Role;Single Nucleotide Polymorphism;Stimulus;Techniques;tool;Translating;Translations;Untranslated RNA;Variant

PROJECT_TITLE: Role of human-specific haplotype diversity on cell fate commitment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-D (55)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Endocrine Disruptors;Skin Cancer

ORG_CITY: DAYTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WRIGHT STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Major questions in photobiology are how environmental ultraviolet radiation (UVR)-treated skin sends systemic signals, as well as potential interactions of UVR with other agents such as pollutants found on skin. This project applies multiple well-established techniques and approaches at cellular and molecular levels to investigate the involvement of the lipid mediator Platelet-activating factor (PAF) in the augmentation of UVR-induced microvesicle particle (MVP) release by the polyaromatic hydrocarbons, anthracene, chrysene, and pyrene. These studies will define the exact mechanism by which these ubiquitous pollutants can interact with UVR with one of the major outcomes being the generation of ROS, PAF, and MVP.

PI_NAMEs: SAHU, RAVI PRAKASH (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: absorption;acid sphingomyelinase;Address;Agonist;Animals;Anthracenes;Area;Aromatic Polycyclic Hydrocarbons;asphalt;Atmosphere;Benzo(a)pyrene;Binding;carcinogenicity;Carcinogens;Career Choice;Cell Line;cell type;Cells;Chrysenes;cigarette smoke;Coal Tar;Complex;County;Coupled;Cytoplasm;design;Diesel Exhaust;Disease;drinking water;Electrons;Energy Transfer;Environmental Pollutants;environmental stressor;Enzymes;Epithelial Cells;Experimental Models;Exposure to;extracellular vesicles;Food;Functional disorder;Future;Gasoline;Generations;Genetic;Grant;ground water;GTP-Binding Proteins;Health Care Research;Human;human subject;immunoregulation;Immunosuppression;In Vitro;inhibitor;keratinocyte;Kidney Diseases;Knowledge;Life;lipid mediator;Lung;Mediating;Mediator;Melanoma;Membrane;Mentorship;Metabolic;microvesicles;Minnesota;Molecular;mortality;Mus;novel;Nuclear;Null Lymphocytes;Outcome;Oxygen;parent project;Parents;particle;Pathologic;Pathway interactions;Petroleum;pharmacologic;Phospholipids;Photobiology;Platelet Activating Factor;platelet activating factor receptor;Play;pollutant;Production;public drinking;Pyrenes;Reaction;Reactive Inhibition;Reactive Oxygen Species;Receptor Signaling;Research Project Grants;response;Role;Signal Transduction;skills;Skin;Skin Cancer;Skin Carcinoma;solar ultraviolet radiation;Stimulus;stressor;Sunlight;synergism;Talents;Techniques;Testing;Toxic effect;Travel;tumor growth;ultraviolet;Ultraviolet B Radiation;Ultraviolet Rays;UV induced;UVB induced;Vesicle;Vitamin D;Wood material

PROJECT_TITLE: Mechanisms of augmented UVB immunosuppressive responses by polyaromatic hydrocarbons


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: UNIVERSITY

ORG_NAME: UNIVERSITY OF MISSISSIPPI

ORG_STATE: MS

PHR: Co-localization of Tyrosine sulfation and O-glycosylation plays critical roles in binding/signaling pathways in biological systems. This proposal aims to use an innovative synthetic chemistry tool to provide a comprehensive understanding of this special arrangement of the two post- translational modifications. We will use structure-defined molecules to map out the complex network of the bindings/signaling pathways, develop new ways of characterizing the structures, and predict potential bindings and binding structures.

PI_NAMEs: ZHU, HAILIANG JOSHUA (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Acids;Binding;biological systems;Cell Adhesion Molecules;Cells;Complex;computational chemistry;Computing Methodologies;Data;design;Enzymes;Funding;Future;G-Protein-Coupled Receptors;Glycopeptides;glycosylation;Goals;Hemostatic Agents;innovation;Libraries;Ligand Binding;Maps;Methods;pathogen;Pattern;Play;Polysaccharides;Post-Translational Protein Processing;Proteins;Role;Serine;Signal Pathway;Signal Transduction;Site;Structure;Sulfate;Synthesis Chemistry;System;Threonine;tool;tyrosine O-sulfate;Work

PROJECT_TITLE: Chemoenzymatic Synthesis of Libraries of Sulfoglycopeptides

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative A better understanding on how limitations in pediatric onco-critical care resources impact ongoing use and sustainability of evidence-based interventions is urgently needed to improve childhood cancer survival in low- resource settings. This project studies how resource availability in low-resource hospitals in Latin American impact the clinical capacity to sustain Pediatric Early Warning System (PEWS)—evidence-based intervention to improve childhood cancer outcomes. Upon completion, this study will identify hospital resources that contribute to sustainability of interventions low-resource hospitals, thus advancing the parent grant’s goal to develop strategies to promote sustainability, thus advancing the field of science of implementation and improving global childhood cancer survival.

PI_NAMEs: AGULNIK, ASYA  (contact);MCKAY, VIRGINIA R

PROGRAM_OFFICER_NAME: CORREA-MENDEZ, MARGARITA

PROJECT_TERMS: Advocate;Affect;Assessment tool;cancer survival;cancer therapy;Child;Childhood;Clinical;Consensus;Critical Care;Critical Illness;Cross-Sectional Studies;Deterioration;Early identification;Evidence based intervention;Face;Goals;Hospitals;Human Resources;implementation science;improved;improved outcome;innovation;Intensive Care;Intervention;Latin America;Latin American;low and middle-income countries;Malignant Childhood Neoplasm;Measures;Methods;Outcome;parent grant;parent project;Patient-Focused Outcomes;Pediatric Oncology;Resource-limited setting;Resources;Role;Sustainable Development;System;tool;Work

PROJECT_TITLE: Sustainability determinants of an intervention to identify clinical deterioration and improve childhood cancer survival in low-resource hospitals

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MORGANTOWN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE There is a critical need to identify the cellular and molecular mechanisms underlying cerebrovascular function in both healthy and disease states associated with aging. The studies in this proposal will investigate how the brain endothelial cell enriched enzyme, tissue nonspecific alkaline phosphatase (TNAP), protects against the loss of cerebral function. The results will identify a potential therapeutic target that may be used improve cerebrovascular function and functional recovery in age-related disorders.

PI_NAMEs: BROWN, CANDICE  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Age;age-related disease;aged;Aging;Alkaline Phosphatase;Alzheimer's Disease;Alzheimer's disease related dementia;Behavior assessment;Blood brain barrier dysfunction;brain endothelial cell;brain magnetic resonance imaging;cadherin 5;Cell Physiology;Cerebral Amyloid Angiopathy;cerebrovascular;Cerebrum;Cognitive;Dementia;Detection;Development;Disease;Endothelium;Enzymes;Event;extracellular vesicles;Functional disorder;Funding;Gene Expression;Genes;Goals;Hemorrhage;Homeostasis;improved;Infarction;Ischemic Stroke;lens;Lesion;Modeling;Molecular;mouse model;Mus;neuropathology;neurovascular;novel;older adult;Pathway interactions;Phenotype;Plasma;post stroke cognitive impairment;post stroke dementia;promoter;Recovery of Function;Role;Series;sex;Stroke;therapeutic target;Tissues;transcriptomics;vascular cognitive impairment and dementia;white matter

PROJECT_TITLE: The role of tissue nonspecific alkaline phosphatase in brain endothelial cell homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(91)-S]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE With assistance from this diversity supplement to R01DK127138 (PI: Anand), Dr. Marimar Contreras-Nieves MD, MS candidate will obtain hands-on research training in her field of interest, kidney disease among agricultural workers. She will work with a field team based in Sri Lanka, statisticians based at Stanford, and geochemist based at the University of Connecticut to evaluate the trajectory of persons with rapid kidney function decline within the cohort recruited under the aims of the parent grant. The project will equip her with field team management and statistical analysis skills, and thereby facilitate her progress to an independent academic career in nephrology.

PI_NAMEs: ANAND, SHUCHI  (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Agricultural Workers;barrier to care;Biostatistics Core;career;Caring;Chronic Kidney Failure;cohort;Connecticut;Cross-Sectional Studies;Data Collection;Environmental Epidemiology;Environmental Risk Factor;Etiology;experience;Goals;hands on research;interdisciplinary approach;interest;Kidney Diseases;Knowledge;Language;longitudinal analysis;Manuscripts;marine;medical schools;Medicine;Mentors;mid-career faculty;multidisciplinary;Nephrology;parent grant;Persons;Politics;Postdoctoral Fellow;Process;professor;Puerto Rico;recruit;Renal function;Research;Research Design;Research Training;Rural Population;Science;skills;Spanish;Sri Lanka;Statistical Data Interpretation;Underserved Population;Universities;Woman;Work

PROJECT_TITLE: Chronic kidney disease of unknown etiology: applying a multidisciplinary approach to investigate the world's most common tubulointerstitial kidney disease

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_DEPT: PEDIATRICS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: PROJECT NARRATIVE Premature birth increases the risk of a chronic lung condition called bronchopulmonary dysplasia, which increases the lifetime burden of medical needs and developmental deficits. Arrest of the growth of lung blood vessels is a key contributor to this condition. Our studies investigate the mechanisms involved in decreased blood vessel growth in the lungs and will identify potential new therapies for this condition.

PI_NAMEs: KONDURI, GIRIJA G. (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: 5'-AMP-activated protein kinase;adenylate kinase;Agonist;Alveolar;angiogenesis;Autopsy;Biogenesis;Blood Vessels;Bronchopulmonary Dysplasia;Caring;Cells;Cellular Metabolic Process;Chronic;Clinical;cofactor;Complication;Data;Development;Down-Regulation;Endothelial Cells;Endothelium;experimental study;fetal;gain of function;Genetic;Genetic Transcription;Growth;Human;Hyperoxia;Impairment;In Vitro;in vivo;jagged1 protein;Knock-out;Knockout Mice;KRP protein;Ligands;Link;loss of function;Lung;lung microvascular endothelial cells;Medical;Metabolic;Metformin;Mitochondria;mitochondrial dysfunction;mortality risk;mouse model;Mus;Neonatal;Neonatal Hyperoxic Injury;neonatal mice;Neurodevelopmental Impairment;new therapeutic target;notch protein;novel;novel therapeutics;overexpression;Oxygen;Phenotype;Phosphotransferases;Premature Birth;Premature Infant;premature lungs;Prevention;Proliferating;pulmonary function;pup;Rattus;Risk;Role;Sampling;Signal Transduction;STK11 gene;Sucrose;supplemental oxygen;Testing;Therapeutic Agents;Transgenic Organisms;Translating;upstream kinase

PROJECT_TITLE: Role of Liver Kinase B1 in the decreased angiogenesis in bronchopulmonary dysplasia

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunotherapy;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The goals of the BMT CTN are to identify and address gaps in transplantation and cellular therapy for blood diseases, train new clinical investigators, contribute to the database and build a biorepository for non-malignant diseases, disseminate results, and improve patient quality of life. The Fred Hutchinson Cancer Center will continue to work with the BMT CTN to achieve its goals by providing scientific leadership, contributing to the development of clinical trials, enrolling patients, and disseminating results to the scientific community and patients. We will train and engage new clinical investigators, particularly those who treat non-malignant diseases, as well as work with BMT CTN to enhance the diversity and inclusivity of the Network.

PI_NAMEs: LEE, STEPHANIE J (contact)

PROJECT_TERMS: Address;Adoptive Cell Transfers;Area;biobank;Blood;Bone Marrow Transplantation;Cancer Center;Cell Therapy;Cellular immunotherapy;chronic graft versus host disease;Clinical;clinical center;clinical development;Clinical Investigator;Clinical Trials;Clinical Trials Network;Collaborations;Communities;Consensus;Databases;Disease;diversity and inclusion;Donor Selection;engineered T cells;Ensure;experience;Faculty;Funding;Genetic Engineering;Goals;graft vs host disease;Health;Hematological Disease;Hematopoietic Stem Cell Transplantation;Hereditary Disease;improved;Infection;interest;international center;Leadership;Malignant - descriptor;member;National Heart, Lung, and Blood Institute;Non-Malignant;novel;Outcome;participant enrollment;Patients;Performance;Phase III Clinical Trials;Play;post-transplant;Prevention;programs;Quality of life;Rare Diseases;Recommendation;recruit;Regimen;relapse prevention;Research;Research Personnel;Role;stem cell expansion;success;symposium;Training;Transplantation;transplantation therapy;United States National Institutes of Health;Work

PROJECT_TITLE: BMT CTN Core - Fred Hutchinson Cancer Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (M1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative In this project we will perform pilot studies to determine how actomyosin defects in neurons contribute to Alzheimer’s disease (AD) pathology. We will also investigate if altering actomyosin can mitigate the loss of synaptic connections and cognitive decline. This work will create a better understanding of the cellular events that cause AD and potentially identify new targets for therapeutic intervention.

PI_NAMEs: VITRIOL, ERIC A (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: abeta oligomer;Acceleration;Acetylation;Actins;Actomyosin;Administrative Supplement;Adult;Age;age related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;APP-PS1;Axon;axonal degeneration;Axonal Transport;Cells;Cytoskeleton;cytotoxicity;Data;Defect;Dendrites;design;Development;Event;experience;F-Actin;FDA approved;Functional disorder;Goals;Hippocampus;Homeostasis;Impaired cognition;innovation;Link;Lysine;Maintenance;Microscopy;Microtubules;Modeling;monomer;Motor;mouse model;Movement;Mus;Myosin ATPase;Myosin S-2;Nerve Degeneration;Neurites;Neurodegenerative Disorders;neuronal cell body;Neurons;new therapeutic target;non-muscle myosin;novel;novel therapeutic intervention;Organelles;Pathologic;Pathology;Pattern;Phenotype;Pilot Projects;Play;Post-Translational Protein Processing;postsynaptic;prevent;Process;Protein Isoforms;Proteins;quantitative imaging;Regulation;Research Personnel;Role;Senile Plaques;spatiotemporal;superresolution imaging;Swelling;Symptoms;Synapses;Techniques;Testing;Therapeutic;Therapeutic Intervention;tool;Tubulin;Visualization;Work

PROJECT_TITLE: Deciphering the Mechanisms and Cellular Roles of Monomer-Driven Actin Dynamics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: NORTH CHICAGO

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

ORG_STATE: IL

PHR: Concentrative nucleoside transporters (CNTs) encoded by the SLC28 gene family, belong to the second nucleoside transporter (NT) family, and contribute to the uptake and biodistribution of nucleoside derived anti-HIV drugs. Unfortunately, while potent and highly selective inhibitors and probes are available to study the biology and pharmacology of their equilibrative transporter (ENT) counterparts, none of such probes are available for CNTs, thus severely hampering progress in their biological studies. This proposal aims at developing the first highly potent and subtype-selective inhibitors for each of the three human (h) CNTs, hCNT1, hCNT2 and hCNT3, to provide chemical tool compounds for studying their physiological and pathophysiology, to allow rational design and optimization of nucleoside reverse transcriptase inhibitors (NRTIs) as HIV/AIDS therapeutic regimens.

PI_NAMEs: BUOLAMWINI, JOHN K (contact)

PROGRAM_OFFICER_NAME: PROTOPOPOVA, MARINA

PROJECT_TERMS: absorption;Acquired Immunodeficiency Syndrome;Address;Adverse effects;Anabolism;analog;Anti-HIV Agents;Anti-viral Agents;antiretroviral therapy;Attention;Biodistribution;Biological;Biological Assay;Biological Products;Biological Testing;Biology;Categories;Cell membrane;Cell Respiration;Cells;Cellular Metabolic Process;chemical synthesis;Chemicals;Clinical;Combined Modality Therapy;computational chemistry;Computer-Aided Design;Cryoelectron Microscopy;Data;Decision Making;design;Didanosine;Docking;Dose;Drug Interactions;Drug or chemical Tissue Distribution;emtricitabine;Exhibits;Family;Family suidae;fetal;Fumarates;Functional disorder;Gene Family;Genes;Genus Hippocampus;Glucose Transporter;Goals;Health;HIV;HIV Infections;HIV Integrase;HIV therapy;Homeostasis;Homology Modeling;Human;human model;improved;in silico;In Vitro;Individual;inhibitor;inhibitor therapy;Integrase Inhibitors;interdisciplinary approach;Kidney;Lamivudine;Lead;Libraries;Ligands;Mediating;member;Membrane Transport Proteins;Metabolic syndrome;Metabolism;Mitochondria;Mitochondrial DNA;Modeling;Modification;Molecular;nephrotoxicity;novel;Nucleic Acids;Nucleoside Transporter;Nucleosides;Nucleotides;Oxygen Consumption;Patient-Focused Outcomes;Pharmaceutical Preparations;pharmacologic;Pharmacology;pharmacophore;Pharmacotherapy;Phlorhizin;Physiological;Play;prevent;Prodrugs;Production;Property;Publishing;Purine Nucleosides;Pyrimidine Nucleosides;rational design;Regimen;Research;reuptake;Reverse Transcriptase Inhibitors;Roentgen Rays;Role;screening;Side;Sodium;solute;Structure;Substrate Specificity;success;Synthesis Chemistry;T-Lymphocyte;Tenofovir;Therapeutic;therapy outcome;Thioinosine;Time;Tissues;tool;Toxic effect;unpublished works;uptake;Vertebral column;Vibrio cholerae;virtual;Virus;Weight Gain;World Health Organization;Zalcitabine;Zidovudine

PROJECT_TITLE: Developing Selective Inhibitors and Probes for Concentrative Nucleoside Transporters

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Neurosciences;Pain Research

ORG_CITY: MANHATTAN

ORG_DEPT: BIOLOGY

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: PROJECT NARRATIVE Tissue-resident macrophages (TRMs) are critical component of innate immune response and are also involved in maintaining body homeostasis and resolving inflammation after injury. Loss of abundance of TRMs and their tissue repair abilities results to tissue damage and diseases. Nociceptor sensory neurons innervate the peripheral sites and tissue microenvironment where TRMs are co-localized but the knowledge about their interactions in maintenance and function of TRMs is lacking. This proposed research will address the key knowledge gaps pertaining to the role of neuron-TRM interactions in inflammation and repair and will ultimately improve our ability to develop therapeutics against inflammatory diseases by targeting their interactions.

PI_NAMEs: BARAL, PANKAJ  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Afferent Neurons;Alveolar Macrophages;body cavity;Calcitonin Gene-Related Peptide;Complex;Data;Development;Disease;Embryonic Development;Exhibits;Functional disorder;gain of function;Greater sac of peritoneum;Homeostasis;immunoregulation;improved;in vivo;Infection;Inflammation;Inflammatory;Injury;Innate Immune Response;Knowledge;Life;Ligands;loss of function;Lung;Macrophage;Maintenance;Mediating;Modality;Modeling;Mus;Nerve;Nerve Fibers;nerve supply;Nervous System;Neurons;Neuropeptide Receptor;Neuropeptides;Nociception;Nociceptors;Pain;Pathogenesis;Peripheral;Peritoneal Macrophages;programs;receptor;Receptor Signaling;Regulation;repaired;Research;Role;Sepsis;Signal Pathway;Signal Transduction;Site;Stimulus;System;Therapeutic;tissue repair;Tissues

PROJECT_TITLE: Neuronal regulation of tissue-resident macrophage maintenance and polarization

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Eye Disease and Disorders of Vision

ORG_CITY: WACO

ORG_DEPT: CHEMISTRY

ORG_NAME: BAYLOR UNIVERSITY

ORG_STATE: TX

PHR: Project narrative: The imagery, data and experimental tools of biomedical science are inaccessible to people with blindness, leading to systemic exclusion. This proposal is utilizing universal design to create and test new technology to make data and laboratory tools of molecular science accessible to lab members with blindness (and other people with blindness). The tools will then be used by sighted and blind members of the PI’s lab to test biomedical hypotheses in bioinorganic and biophysical chemistry.

PI_NAMEs: SHAW, BRYAN F. (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: 3-Dimensional;3D Print;Adult;Affect;aged;Amides;Amyotrophic Lateral Sclerosis;analytical tool;Biochemical;Biochemical Reaction;Biochemistry;Bioinorganic Chemistry;Biology;Biomedical Research;biophysical chemistry;blind;Blindness;Capillary Electrophoresis;career;Charge;Chemicals;Collaborations;college;Color;Communication;computer scientist;Coupled;Coupling;crosslink;Cryoelectron Microscopy;Cu-Superoxide Dismutase;Cuprozinc Superoxide Dismutase;cytochrome c;Dangerousness;Data;Data Analyses;data format;design;Devices;Distal;Doctor of Philosophy;Drops;Electron Transport;Electrons;Electrostatics;Engravings;Enzymes;Exclusion;experience;explicit bias;Face;Faculty;Fluorescence Spectroscopy;Funding;Gel;Hand;haptics;High Pressure Liquid Chromatography;Imagery;Institution;instrument;Intervention;invention;Journals;Kinetics;Laboratories;light scattering;Link;member;Metalloproteins;Metals;meter;Mitochondria;Molecular;Morphology;Mutagenesis;mutant;new technology;Normal Range;Optics;Outcome;Oxidation-Reduction;peer;Peer Review;Persons;Play;Postdoctoral Fellow;Preparation;Process;programs;Property;Protein Biochemistry;protein misfolding;protein purification;protein structure;Proteins;Protons;Publishing;Regulation;Research;Research Personnel;Resolution;robotic device;Robotics;Role;Science;Scientist;Seasons;Self-Help Devices;Site-Directed Mutagenesis;Solid;Structure;Students;Superoxide Dismutase;Swelling;synergism;System;Tactile;Techniques;Technology;Testing;Texas;Thermodynamics;three-dimensional modeling;tool;touchscreen;Training;Twin Multiple Birth;undergraduate student;United States National Institutes of Health;virtual;Vision;Visual impairment;Visualization;Western Blotting;wireless;Work

PROJECT_TITLE: Creating tools to make experimental biochemistry accessible to people with blindness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (56)]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Obesity

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative Nonalcoholic steatohepatitis (NASH) is highly prevalent globally that can lead to cirrhosis, liver failure and cancer; however, no FDA approved therapy is currently available. Our work will investigate our hypothesis that an adipokine we identified activates a metabolic signaling pathway in the liver and that this adipokine may serve as a potential therapeutic agent for the treatment of NASH and metabolic diseases.

PI_NAMEs: WANG, YONG-XU  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: 5'-AMP-activated protein kinase;Ablation;Acceleration;Acute;Address;Adipocytes;adipokines;Adipose tissue;Amino Acids;AMP-activated protein kinase kinase;analog;Animal Model;Binding;Biogenesis;Body Weight Changes;Brown Fat;Cardiovascular Diseases;Cause of Death;Cell surface;Cholesterol;Choline Deficiency;Cirrhosis;Clinical;Clinical Trials;comorbidity;CRISPR/Cas technology;Data;Development;Diet;diet-induced obesity;Dose;Dyslipidemias;Eating;Event;Failure;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Fatty Liver;FDA approved;Fibrosis;Fructose;Gene Expression;Gene set enrichment analysis;Hepatic;Hepatocyte;High Fat Diet;High Prevalence;Human;Hyperglycemia;Hyperinsulinism;Hypertriglyceridemia;improved;in vivo;Inflammation;Insulin Resistance;Knock-out;Knockout Mice;Ligands;lipid biosynthesis;lipid metabolism;Lipids;Liver;Liver Failure;Lobular;Malignant neoplasm of liver;Maps;Marketing;Mediating;Metabolic;Metabolic Diseases;Metabolic syndrome;Mitochondria;Molecular;mouse model;Mus;Names;non-alcoholic fatty liver;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Obese Mice;Obesity;oxidation;Oxidative Phosphorylation;Pathogenesis;Patients;Pharmaceutical Preparations;Phenotype;phosphoproteomics;Phosphorylation;Prevalence;programs;protein kinase inhibitor;Proteins;Proteomics;receptor;Receptor Protein-Tyrosine Kinases;Recombinant Proteins;Recombinants;Repression;Resolution;Serum;Signal Pathway;Signal Transduction;Signaling Molecule;STK11 gene;Therapeutic;Therapeutic Agents;Thermogenesis;transcriptome sequencing;unpublished works;Weight Gain;Work

PROJECT_TITLE: Resolution of nonalcoholic fatty liver and nonalcoholic steatohepatitis by a novel adipokine

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE In Chicago, youth from disadvantaged backgrounds on the South and West sides are exposed to alarmingly high levels of community violence, which detrimentally impacts their overall well-being. This project aims to evaluate a novel violence prevention program to address structural inequities—Community Health Advocates in Mitigating and Preventing Violence (CHAMP-V) with and without Legal Aid Wraparound (LAW). Results from this project will provide rigorous evidence about the effect of community health advocacy and legal advocacy strategies to prevent community violence for youth and their families while offering a scalable approach can target all levels of the social-ecological model.

PI_NAMEs: TUNG, ELIZABETH LUNJUN;VOLERMAN, ANNA  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Adolescent;Advocacy;Advocate;Affect;Behavior Therapy;Behavioral;Caregivers;Chicago;Child;children of color;Cluster randomized trial;cohort;Color;Communities;Community Health;Community Health Aides;community violence;Data;Disadvantaged;disadvantaged background;Economics;Education;education resources;Effectiveness;effectiveness evaluation;effectiveness/implementation study;Employment;Ensure;Evidence based practice;experience;Exposure to;Family;Family Violence;Focus Groups;Frontline worker;gang;group intervention;Health;health care quality;health care settings;Health education;health inequalities;Health Resources;Health Services;high school;Home environment;Housing;implementation determinants;implementation evaluation;improved;Individual;Inequity;Interruption;Intervention;Interview;Investments;junior high school;Lawyers;Legal;Link;maladaptive behavior;Medical;member;Mental Health;Modeling;mortality;mortality disparity;Neighborhoods;novel;Outcome;Parents;peer violence;Performance;perpetrators;Personal Satisfaction;Police;poor health outcome;Poverty;prevent;Prevention program;preventive intervention;Primary Prevention;programs;protective factors;Public Health;Race;racial health disparity;Racial Segregation;racism;Reporting;Research;Resources;Risk;School Enrollments;Schools;Secondary Prevention;service delivery;Side;social;Social Welfare;Social Work;stem;Stress;structural determinants;Structure;Students;Surveys;System;Testing;Trauma;trauma exposure;trial comparing;Trust;Unemployment;Victimization;Violence;violence exposure;violence prevention;Work;Youth;youth violence;youth violence prevention

PROJECT_TITLE: CHAMP-V + LAW: A program to prevent youth violence by addressing upstream structural determinants through community health worker and civil legal aid interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (M1)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;Neurosciences;Pediatric;Precision Medicine

PHR: PROJECT NARRATIVE This study takes a multi-modal approach to investigate root causes of aberrant brain-gut signaling in children diagnosed with ‘functional’ gastrointestinal disorders but suffering from multisystem complaints concerning for autonomic dysregulation. The project brings together a team of productive scientists across several disciplines, applying cutting-edge technology and validated metrics to build on established, successful collaborations. Guided by solid preliminary data and published evidence, this multidisciplinary proposal investigates brain-gut physiology while providing a path towards personalized medicine using non-invasive, evidence-based neuromodulation therapies.

PI_NAMEs: KARRENTO, KATJA KRISTINA (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Adolescence;Affect;Afferent Pathways;Anti-Cholinergics;anti-depressive agents;Anxiety;Autonomic nervous system;Benign;Brain;Brain Stem;Cardiac;Cell Nucleus;Child;Childhood;Chronic;Clinical;clinical efficacy;clinical practice;Collaborations;comorbidity;comparative efficacy;Computer software;Data;Diagnosis;Disabling;Discipline;Disease;disorders of gut-brain interaction;Dizziness;drug standard;Dysautonomias;Dyspepsia;effective therapy;efficacy evaluation;Equilibrium;Etiology;evidence base;Fatigue;feasibility testing;Feedback;Female;Functional disorder;Functional Gastrointestinal Disorders;Goals;gut-brain axis;Heart Rate;Hypersensitivity;Hypnotherapy;Impaired cognition;indexing;Individual;Interoception;Intervention;Intestines;Knowledge;Link;Magnetic Resonance Imaging;Measures;motility disorder;Motor;motor disorder;multidisciplinary;multimodality;Nausea;Nausea and Vomiting;Nerve;Nervous System Physiology;neuroregulation;Nonpharmacologic Therapy;novel;Outcome;Outcome Assessment;Output;Pain;Palpitations;Pathway interactions;patient subsets;Patients;Periodicity;personalized approach;personalized medicine;Pharmaceutical Preparations;Pharmacotherapy;Physiology;point of care;Posture;predicting response;Prediction of Response to Therapy;primary outcome;Productivity;prototype;Psychophysiologic Disorders;Publishing;rate of change;Regulation;Research;respiratory;response;Risk;Scientist;Sensory Thresholds;side effect;Signal Transduction;Sinus;Sleep Disorders;Sleep disturbances;software systems;Software Tools;Solid;standard of care;Stomach;Symptoms;Syndrome;System;targeted treatment;Technology;Testing;Time;tool;Visceral;Vomiting

PROJECT_TITLE: Autonomic Reactivity to Restore a Dysregulated Brain-Gut Axis via Targeted Therapy

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE The proposed administrative supplement will support pilot work for a project to quantify the effect of structural white advantage (SWA) – policies and practices that provide greater resources and power to people racialized as white – on cognitive health and Alzheimer’s diseases and related dementias (ADRD) risk among older US adults. Understanding the linkage between SWA and cognitive health may reveal the effectiveness of policies/programs that target the distribution of resources to dominated groups (non-white) to promote health equity. Additionally, the SWA framework provides a theoretical grounding to dissect potential heterogeneities in cognitive reserve processes and outcomes among those racialized as white, providing additional clues on how the intersection among structural inequities (e.g., SWA and classism) determine ADRD disparities at the population level.

PI_NAMEs: FLOOD, SARAH M (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Administrative Supplement;Adult;African American population;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Biological;Biological Markers;Biosocial;Black race;C-reactive protein;cardiometabolic risk;cardiometabolism;cardiovascular risk factor;Cardiovascular system;Caucasians;Cholesterol;classism;Cognitive;cognitive function;cognitive reserve;cohort;Complex;Criminal Justice;Data;dementia risk;Demography;Development;Disparity;driving force;Economics;Education;Effectiveness;Employment Opportunities;Equity;ethnoracial;experience;Exposure to;Factor Analysis;falls;Floods;Fostering;Funding;Geography;Glycosylated hemoglobin A;Goals;Grant;Health;health equity promotion;Health Insurance;Heterogeneity;high risk;Hispanic;Housing;indexing;Inequity;Inflammation;innovation;insight;interdisciplinary collaboration;Intervention;Investigation;Investments;Knowledge;large scale data;late life;Life;Life Cycle Stages;Link;Low-Density Lipoproteins;Measures;Memory;Memory Loss;Methodology;middle age;Minnesota;Neighborhoods;novel;older adult;Outcome;Participant;Persons;Pilot Projects;Policies;Population;post gamma-globulins;Process;programs;Property;public education;Race;racial discrimination;racial disparity;Renal function;Reproductive Health;Research;Research Personnel;Resources;Retirement;Risk;Risk Factors;Social Hierarchy;Social Network;Societies;Specific qualifier value;structural determinants;Structural Racism;Surveys;System;Taxes;Testing;trend;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Life Course Center for the Demography and Economics of Aging


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: The discovery and characterization of BRCA1 and BRCA2 and their sister genes have had tremendous impact on prevention and treatment of breast and ovarian cancer, yet family history remains one of the most important risk factors for these cancers, and a great deal of that risk remains unexplained as the result of technical limitations of current genomics technologies. The goal of this project is to deploy transformative new technologies on behalf of these families. This project is intended to stimulate discovery of causal genetic events for inherited breast and ovarian cancer and thereby for other inherited illnesses.

PI_NAMEs: KING, MARY-CLAIRE  (contact);WALSH, TOMAS D

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Affect;Alleles;Award;BARD1 gene;Biological Assay;BRCA1 gene;BRCA2 gene;Breast Cancer gene;Breast Cancer Risk Factor;Breast Cancer Treatment;Cancer cell line;cancer prevention;cancer therapy;candidate identification;causal variant;cell type;Cells;CHEK2 gene;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complementary DNA;Complex;Development;Disease;Epithelial Cells;ESR1 gene;Event;experimental analysis;Extended Family;Family;Fiber;Fortune;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Predisposition to Disease;Genetic Transcription;Genetic Variation;genome wide association study;genome-wide;Genomics;Goals;Hand;Homologous Gene;induced pluripotent stem cell;Inherited;insertion/deletion mutation;Introns;loss of function mutation;lymphoblast;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;mammary;MCF10A cells;Mutation;Neighborhoods;new technology;Nucleic Acid Regulatory Sequences;Oncogenes;PALB2 gene;Participant;Pathogenicity;Patients;Phenotype;Prevention;Privatization;Process;promoter;Publications;RAD51C gene;rare variant;recombinational repair;Recording of previous events;Reporter;Reporting;Risk;Risk Factors;RNA Splicing;Role;Sampling;segregation;Sister;Site;success;Technology;Testing;TFF1 gene;TP53 gene;Transcript;Untranslated RNA;Variant

PROJECT_TITLE: Genomic Analysis of Inherited Breast and Ovarian Cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Repurposing thermally-activated enzymes with photoexcitation has emerged as a promising strategy for realizing challenging reactions in pharmaceutical synthesis, such as asymmetric radical reactions. We propose to develop computational tools for understanding the mechanisms of photoenzymes and for designing new enzyme variants and protein scaffolds capable of photoenzymatic reactions. We envision that our computational framework will greatly accelerate the development of photoenzymes for synthesizing pharmaceuticals and will in the long term also facilitate the identification of natural enzymes that may have previously unknown photoenzymatic activity as new drug targets, thus having high impact on human health.

PI_NAMEs: DONG, SIJIA  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Amino Acid Sequence;catalyst;chemical reaction;cofactor;Collection;computer framework;computerized tools;Computing Methodologies;Data;Descriptor;design;Development;drug-like compound;Electronics;Engineering;Enzymes;Flavins;Health;Human;light effects;Machine Learning;Methods;Molecular;Mutate;new therapeutic target;novel;Oxidoreductase;Pharmacologic Substance;Physics;programs;prototype;Reaction;Research;scaffold;Scaffolding Protein;simulation;small molecule;System;Testing;tool development;Variant

PROJECT_TITLE: Computational Framework for the Mechanistic Studies and Physics-Informed Prediction and Design of Photoenzymes

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Nutrition;Women's Health Research

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Circadian rhythms allow organisms to coordinate their behavior and physiology with daily and seasonal changes but also temporally coordinate internal processes across organ systems. Although the overall architecture of circadian systems is conserved across phylogeny and between sexes, circadian systems are not identical between sexes. The goal of this proposal is to investigate fundamental biology of sex differences in circadian function from the brain to peripheral tissues across the lifespan and under conditions of dietary stress, identifying principles that will allow us to leverage chronobiology to improve human health in more personalized ways.

PI_NAMEs: BARBER, ANNIKA FITZPATRICK (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Age;Aging;Animals;Architecture;Behavior;Behavioral;Behavioral Genetics;behavioral study;Biology;Body System;Brain;Cell Count;Chronobiology;circadian;circadian biology;circadian pacemaker;Circadian Rhythms;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Data;Diet;dietary;Drosophila melanogaster;Exposure to;Fatty acid glycerol esters;Female;fly;Gene Expression;Genetic;Genetic Models;Genetic Transcription;Goals;Health;High Fat Diet;Human;imaging approach;improved;in silico;in vivo;insight;Insulin;insulin signaling;Knock-out;Knowledge;Life;life span;luminescence;male;Maps;Metabolic;metabolic abnormality assessment;Molecular;Morphology;Neurons;Neuropeptides;novel;Nutritional;Organism;Output;Partner in relationship;Peripheral;Phylogeny;Physiology;Process;programs;Publishing;receptor;response;Role;screening;Seasons;sex;Sex Differences;sexual dimorphism;Signal Transduction;Signaling Molecule;Stress;stressor;sugar;System;Techniques;Time;Tissues

PROJECT_TITLE: Sex differences in circadian output signaling


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Chronic Pain;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Neurosciences;Pain Research;Rare Diseases;Sickle Cell Disease;Social Determinants of Health

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE We propose to build the Sickle Cell Disease Pain Analgesia and Integrative Network (SCDPAIN) as an innovative, dynamic and interactive platform that will advance the NCCIH's mission for research on pain mechanisms in sickle cell disease (SCD) through multimodal dissemination efforts. Guided by an unmet need to address the morbidity associated with pain in SCD, we will assemble leading investigators in SCD pathobiology, pain, organ damage and integrative medicine to collaborate for advancing basic and translational science using cutting-edge technology, passionate mentoring and pilot funding to the future leaders, promoting diversity and inclusion to conduct innovative research to transform scientific advancements in SCD pain.

PI_NAMEs: CAMPBELL, CLAUDIA MICHELLE;GUPTA, KALPNA  (contact);SMITH, WALLY R

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Absence of pain sensation;Acceleration;Acute Pain;Address;Adult;Affect;Animals;Area;Artificial Intelligence;Basic Science;Behavioral;Behavioral Genetics;Behavioral Sciences;Biological;Biology;Blood - brain barrier anatomy;Brain;Cells;Central Nervous System;Cessation of life;Characteristics;chronic pain;Collaborations;Communication;community partners;comorbidity;cytokine release syndrome;Databases;Dedications;Development;Dimensions;Disease;diversity and equity;diversity and inclusion;Dreams;drug development;Educational workshop;Engineering;Enhancement Technology;Ensure;experience;Fetal health;Funding;Future;Future Generations;Goals;Grant;Health;health care service utilization;Heme;Hemoglobinopathies;holistic approach;Hospitalization;Human;humanized mouse;improved;Incentives;Incubators;Individual;infancy;innovation;insight;Integrative Medicine;Integrative Therapy;Interdisciplinary Study;International;Interoception;Intervention;Ischemia;Kidney Failure;Lead;Leadership;Leg Ulcer;Life;life span;Maternal Health;meetings;Mentors;Methods;Mission;Modeling;Morbidity - disease rate;mortality;mouse model;multidisciplinary;multimodality;Mus;National Center for Complementary and Integrative Health;Nature;Necrosis;Neuroglia;neuroimaging;Neurons;next generation;novel;opioid use;Organ;Oxidative Stress;Pain;Pain management;pain outcome;pain perception;Pain Research;Pathology;Peripheral Nervous System;Persons;Pilot Projects;Poverty;Productivity;programs;Provider;psychosocial;Quality of life;racism;Rare Diseases;recruit;Recurrence;Reduce health disparities;Refractory;Reperfusion Injury;Research;Research Personnel;Resource-limited setting;Resources;response;sabbatical;Science;Scientific Advances and Accomplishments;scientific organization;Scientist;Series;Sickle Cell;Sickle Cell Anemia;sickling;social stigma;success;symposium;Technology;Training;translational potential;Translational Research;Treatment Side Effects;vaso-occlusive crisis;virtual;Visit;Work;working group

PROJECT_TITLE: Sickle Cell Disease Pain Analgesia And Integrative Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 MH (08)]


ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Project Narrative Systemic amyloidosis is a disease caused by the continual build-up of misfolded proteins in organs and tissues throughout the body. These proteins, not naturally recognized and cleared by the body, fibrilize and destroy organ architecture thereby limiting effective organ function. Here we report that collagen-1 impedes immune cell recognition of amyloid deposits and propose therapeutic intervention strategies to overcome this effect.

PI_NAMEs: JACKSON, JOSEPH WILSON (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Address;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Amyloid Fibrils;amyloid peptide;Amyloidosis;Antibodies;Antibody Therapy;Apolipoprotein E;Architecture;Back;Basement membrane;Binding;Biodistribution;Biological Assay;care seeking;Catalytic Domain;CD36 gene;Cell Physiology;cell type;Cells;Cessation of life;Chimeric Proteins;Clinical;clinical efficacy;Collagen;Collagen Fibril;collagenase;combinatorial;Companions;comparison control;Complement 3a;Complement 5a;Coupling;CRISPR/Cas technology;curative treatments;Data;Deposition;design;Development;Diagnosis;Disease;Disease Outcome;Environment;Excision;extracellular;Extracellular Space;Family;Functional disorder;Gelatinase B;Generations;Goals;Human;Immune;immune activation;immune stimulatory agent;Immune system;Immunologic Stimulation;immunoregulation;Immunotherapeutic agent;In Vitro;in vivo;Interstitial Collagenase;Intervention;Knock-out;Lesion;Macrophage;Mass Spectrum Analysis;Matrix Metalloproteinases;Measures;Mediating;Microglia;misfolded protein;Modality;Modeling;Morbidity - disease rate;mouse model;Mus;Organ;Pathologic;Patients;Peptides;Phagocytosis;Predisposition;prevent;Process;Production;Property;protein aggregation;Protein Biosynthesis;protein misfolding;Protein Precursors;Proteins;Proteome;Reagent;Receptor Inhibition;Refractory;Reporting;scavenger receptor;Serum Amyloid P-Component;Substance P;Therapeutic;Therapeutic Intervention;Tissues;Treatment Efficacy;uptake;β-amyloid burden

PROJECT_TITLE: Addressing Collagen Mediated Protection of Systemic Amyloid Fibrils

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative This proposal will examine the fundamental mechanism underlying alcohol effects on the vulnerability to the cognitive impairments associated with Alzheimer Disease (AD). We will explore the hypothesis that genetic risk for alcohol consumption contributes to the risk of developing AD, even in the absence of exposure to alcohol. We will use the largest available genetic studies of AD in humans to extract genetic component of the risk of AD, and, using sophisticated statistical techniques, will estimate the contribution of genetic risk for alcohol consumption, measured in a rat model.

PI_NAMEs: IM, HAE KYUNG ;PALMER, ABRAHAM A (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Address;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol use disorder;Alcohols;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Animal Disease Models;behavior measurement;burden of illness;Data;Dementia;Environmental Exposure;Exposure to;Genetic;genetic approach;Genetic Risk;Genetic study;Heavy Drinking;high risk;Human;Human Genetics;Impaired cognition;Knowledge;Link;Measures;Modeling;National Institute on Alcohol Abuse and Alcoholism;parent grant;Phenotype;population genetic structure;Rattus;response;Risk;Scoring Method;System;Techniques;transcriptomics;Translating;Withdrawal

PROJECT_TITLE: A Framework for Translating Polygenic Findings Related to Alcohol Use Disorder Across Species

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention;Serious Mental Illness

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The role of late life depression in cognitive decline and Alzheimer’s Disease risk Narrative The risk of developing Alzheimer’s Disease increases by three-fold for people who experience symptoms of depression in older age. The goal of this administrative supplement to parent R01 MH128286 is to identify shared neural mechanisms of depressive symptoms and cognitive decline in late life, and to establish how late life depression influences the development of cognitive decline and Alzheimer’s Disease pathophysiology.

PI_NAMEs: BIJSTERBOSCH, JANINE DIANE (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Address;Administrative Supplement;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;biobank;Brain;cardiovascular risk factor;cingulate cortex;clinical heterogeneity;Cognitive;cognitive ability;cognitive testing;cohort;Collaborations;Data;Data Set;depressive symptoms;design;Development;Diagnosis;Equation;executive function;experience;Female;follow-up;Functional disorder;Funding;Genetic Risk;genetic risk factor;geriatric depression;Goals;Grant;human old age (65+);Image;Impaired cognition;Individual;late life;Link;male;Memory;Mental Depression;Modeling;modifiable risk;neural correlate;Neurobiology;neuroimaging;neuromechanism;neuropsychiatric symptom;Parents;Pathway interactions;Patients;Persons;Phenotype;Population;pre-clinical;programs;Reaction;Reaction Time;Recording of previous events;Research;Research Project Grants;response;Risk;Risk Factors;Role;Sampling;sex as a biological variable;symptomatology;Symptoms;tau Proteins;Testing;United States National Institutes of Health;visual memory;Work

PROJECT_TITLE: The role of late life depression in cognitive decline and Alzheimer's Disease risk

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: MADISON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Narrative While regulation of the shape and form of the energy generating organelles, mitochondria, through fission and fusion (mitochondrial dynamics) is linked to a variety of complex cellular processes, the exact relations between mitochondrial form and function are still not fully understood. In this study, we will examine the roles of mitochondrial dynamics in retinal rod photoreceptor cells that display unique shape and arrangement of mitochondria using mouse models. Successful completion of this study will provide novel insights into the relationship between mitochondrial form and function as well as the functional significance of mitochondrial dynamics in the retinal health, and may suggest novel therapeutic strategies for retinal conditions associated with mitochondrial abnormalities.

PI_NAMEs: IKEDA, AKIHIRO  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 1 year old;Ablation;Adult;Affect;Age;Age Months;age related;Aging;Anabolism;Biological Assay;Cell Death;Cell Physiology;Cells;Chimeric Proteins;Complex;Data;Development;Dynamin;Functional disorder;Gene Expression;Genus Hippocampus;Glycolysis;Health;Immune response;insight;Link;Lipids;Maintenance;Mediating;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Modeling;mouse model;multiple omics;Mus;Nerve Degeneration;Neurons;novel;novel therapeutic intervention;Organelles;Pathology;Photoreceptors;Play;postnatal;postnatal development;Presynaptic Terminals;Proteins;Quality Control;Regulation;Retina;Retinal Degeneration;retinal rods;Role;Serine;Shapes;Structure;Testing;translational impact

PROJECT_TITLE: Role of mitochondrial dynamics in rod photoreceptor cells

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

ORG_NAME: TUFTS MEDICAL CENTER

PHR: Project Narrative Vasoproliferative retinopathies are the leading causes of blindness. Understanding the molecular underpinnings of retinal vascular diseases is essential for discovering novel or improved therapeutic options. This proposal aims to determine how distinct innate immune signaling controls the growth and regression of neovessels.

PI_NAMEs: GNANAGURU, GOPALAN  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Affect;age group;Animals;Astrocytes;Binding;Blindness;Blood Vessels;C5a anaphylatoxin receptor;Cell Separation;cell type;Cells;chemokine;Childhood;Complement;Complement 3a;Complement 5a;Complement Activation;complement C3a receptor;complement pathway;Complement Receptor;Complex;Cues;Data;Development;Endothelial Cells;Endothelium;Ensure;Epitopes;glial activation;Goals;Growth;Immune;Immune signaling;immunoregulation;improved;In Situ Hybridization;indexing;innovation;Ischemia;Kinetics;Ligands;Macrophage;Macrophage-1 Antigen;Magnetism;Mediating;Microglia;migration;Molecular;Molecular Profiling;mouse model;mRNA sequencing;Muller's cell;multimodality;Mus;Myeloid Cells;neovascular;neovascularization;neuroinflammation;novel;novel therapeutic intervention;Oxygen;Pathogenesis;Pathologic;Pathologic Neovascularization;Pathology;Peripheral;Phase;Physiological;Population;Process;receptor;recruit;Reporter;Resolution;response;Retina;retinal angiogenesis;Retinal Detachment;Retinal Diseases;Retinal Neovascularization;Retinopathy of Prematurity;Reverse Transcriptase Polymerase Chain Reaction;RiboTag;Role;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Sorting;Source;spatiotemporal;Testing;Therapeutic;transcriptome;treatment strategy;Vascular Diseases;vessel regression

PROJECT_TITLE: Innate immunomodulation of retinal neovascularization

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: DNA methylation is a heritable epigenetic mark that is dynamically remodeled in development and largely stable in adult soma. Recurrent genome wide DNA methylation aberrations are common upon excessive proliferations, whose molecular basis and functional consequences remain poorly understood. Using mouse skin as our model, we study the role of DNA methylation in bridging retrotransposon control and adult stem cell fate decisions.

PI_NAMEs: GE, YEJING  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Adult;adult stem cell;aged;Aging;Centromere;Code;Cytosine;demethylation;derepression;Development;DNA Methylation;Embryonic Development;Epigenetic Process;Euchromatin;Eukaryota;fitness;functional decline;Gene Expression;Genes;Genetic Models;Genome;genome-wide;Genomics;Hair follicle structure;Heritability;Heterochromatin;histone methylation;Homeostasis;Hypermethylation;Inherited;insight;Junk DNA;Link;Malignant - descriptor;Malignant Neoplasms;mammalian genome;Mediating;Methylation;Modeling;Molecular;Mus;Natural regeneration;Nature;neuronal cell body;Pathway interactions;Physiological;Play;postnatal;preimplantation;Proliferating;promoter;Proteins;Recurrence;Regulation;Repetitive Sequence;Retrotransposon;Role;Skin;stem cell fate;stem cell function;stem cells;Stress;Tandem Repeat Sequences;telomere;Tissues;Titrations;Variant;wound

PROJECT_TITLE: Dissecting the role of DNA methylation in controlling retrotransposons and governing adult stem cell fates

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Public health relevance statement Transmembrane transporters play vital roles in cell physiology, diseases, and therapy; however, their insertion into lipid bilayers makes them challenging systems to investigate computationally and experimentally. Among transmembrane transporters, alkali and alkaline earth metal cation transporters received significant attention, while the anion and transition metal transporters have not. The proposed project will establish a computational framework to systematically investigate the complex anion and transition metal transporters to uncover the underlying biochemical and molecular basis for ion selectivity and transport mechanism.

PI_NAMEs: TORABIFARD, HEDIEH  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Alkalies;Alkaline Earth Metals;Anions;Antibiotics;antiporter;ATP phosphohydrolase;Attention;Biochemical;Biological;biological systems;Biomedical Engineering;biomedical scientist;Biophysics;Cations;Cell Physiology;Cells;Cellular Membrane;Chemistry;chemotherapeutic agent;Complex;complex biological systems;computational platform;Computational Technique;computer framework;Cystic Fibrosis;design;Development;Disease;Drug resistance;experience;Family;Fluoride Ion;Fluorides;Gatekeeping;Generations;Goals;Hepatolenticular Degeneration;human disease;inhibitor;innovation;Integral Membrane Protein;Investigation;Ion Channel;Ion Transport;Ions;Knowledge;Laboratories;Link;Lipid Bilayers;Lipids;Maps;Membrane Transport Proteins;Metals;Modeling;Molecular;Molecular Conformation;molecular mechanics;Monitor;Mutation;Myotonia;neglect;novel;Nutrient;Outcome;Pharmaceutical Preparations;Phylogenetic Analysis;Play;Property;Protein Export Pathway;Protons;public health relevance;Quantum Mechanics;Research;Resistance;Role;Statistical Mechanics;stoichiometry;System;Therapeutic Agents;therapeutically effective;Toxin;Training;Transition Elements

PROJECT_TITLE: Computational framework to investigate the inorganic ion transporters

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: Project Narrative The human genome is folded into chromatin loops and domains, which are critical for cellular activities and functions, and misfolding of these structures can cause many human diseases including cancer. Using our unique semi-in vitro system, we will provide better understanding of the molecular mechanisms that fold and regulate the genome in both healthy and diseased cells.

PI_NAMEs: LIU, YU  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Affect;Binding;Biochemical;Cell Nucleus;Cells;Chromatin;Chromatin Loop;clinically relevant;cohesin;Complex;Disease;Dose;Enhancers;Genetic Transcription;Genome;Goals;human disease;Human Genome;In Vitro;innovation;Interphase;Malignant Neoplasms;Mediating;Methodology;Methods;Molecular;Molecular Conformation;Molecular Probes;Mutation;novel;predictive modeling;Process;promoter;Regulation;Research;Role;Structure;System;three dimensional structure;Variant;Vision

PROJECT_TITLE: Mechanistic Studies of Genome Folding

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE The long-term goal of the RCMI Specialized Center, Ola HAWAII, is to improve minority health and reduce health disparities for those communities in Hawaii which suffer disproportionately in health outcomes and healthcare access. In the next five years, the objective of the Center is to lead and advance minority health and health disparities research in Hawaii. Ola HAWAII has assembled an exemplary team to build institutional capacity in basic biomedical, clinical and behavioral research; engage underserved communities; mentor and support a diversified workforce; and enhance core facilities and resources.

PI_NAMEs: HEDGES, JERRIS ROBERT (contact);MOKUAU, NOREEN

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Acceleration;Address;Amyloid beta-Protein;Area;aspirate;base;Basic Science;Behavioral Research;Biomedical Research;Burn injury;Cardiovascular Diseases;Climacteric;Clinical Research;Collaborations;Communities;community collaboration;Community Participation;Core Facility;COVID-19;Diabetes Mellitus;Disparity;Ethnic Population;Evaluation;Faculty;Filipino;Funding;Goals;Hawaii;Hawaiian;healing;Health;health care availability;Health Disparities Research;health disparity;health equity;Health Policy;improve minority health;improved;Inequality;innovation;Institution;institutional capacity;Insulin;Island;Lead;Letters;Malignant Neoplasms;Measures;medical schools;medically underserved;Mentors;minority health;minority health disparity;Minority-Serving Institution;Names;National Institute on Minority Health and Health Disparities;Native Hawaiian or Other Pacific Islander;Neurons;novel strategies;Outcome;Outcomes Research;Pilot Projects;Policies;Policy Developments;Postdoctoral Fellow;Principal Investigator;Process;Productivity;programs;Public Health;racial population;recruit;Reduce health disparities;Research;research facility;Research Personnel;Resource Allocation;Resource Sharing;Resources;Services;Specialized Center;success;Translations;Trust;underserved community;Underserved Population;Universities;Work

PROJECT_TITLE: The exocyst as an insulin-sensitive regulator of amyloid-beta in neurons


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE While phosphate is involved in many fundamental cell processes including DNA synthesis, bone formation, and storage of energy in high energy phosphates, it is unknown how mammalian cells sense and regulate phosphate homeostasis to avoid deficiency or excess. Phosphate deficiency can lead to serious complications including muscle breakdown; conversely, phosphate excess predisposes to heart attacks and strokes, which is especially problematic for many of the 60% of Americans who are affected by chronic kidney disease over their lifetime. Our preliminary work has identified several pathways that regulate cellular phosphate homeostasis and sensing of phosphate availability that are the foundation of this proposal.

PI_NAMEs: ZECHNER, PETER GERHARD CHRISTOPH (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;American;Biological Process;Cardiovascular Diseases;Cell membrane;Cell Physiology;Cells;Chronic Kidney Failure;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;design;DNA biosynthesis;DNA Sequence Alteration;Foundations;Genetic;Genetic Screening;genome-wide;Goals;Homeostasis;inorganic phosphate;Inorganic Phosphate Transporter;loss of function;Malignant Neoplasms;Mammalian Cell;member;Muscular Atrophy;Myocardial Infarction;novel;Nutrient;Osteogenesis;Pathway interactions;Patients;pharmacologic;Phenotype;Play;Premature aging syndrome;preservation;Process;Protein Biosynthesis;protein degradation;Proteins;proteostasis;Recycling;Regulation;Rhabdomyolysis;RNA chemical synthesis;Role;Sodium;Starvation;Stroke;Syndrome;uptake;Vascular calcification;Work

PROJECT_TITLE: Proteostasis and Phosphate Sensing in the Regulation of the Phosphate Transporter SLC20A1


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

PHR: PROJECT NARRATIVE Early social interactions, especially negative ones, can result in long lasting behavior phenotypes. Here we introduce a unique ant species Harpegnathos saltator as a model for studying how epigenetic factors and gene regulation influence neuronal circuitry and social behaviors. The aims of this research proposal are how social interactions induce epigenetic changes, create ant models for autism spectrum disorders, and to uncover the epigenetic mechanisms underlying social behavior.

PI_NAMEs: GOSPOCIC, JANKO  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Adult;Aggressive behavior;Animals;Ants;autism spectrum disorder;Behavior;Behavior Control;Behavior Disorders;behavioral phenotyping;Biological Models;Brain;Castes;Chromatin;Conflict (Psychology);Disease;Epigenetic Process;epigenetic regulation;extend lifespan;Gene Expression;Gene Expression Regulation;Genome;Homologous Gene;Human;Individual;insight;interest;model of autism spectrum disorder;Modeling;mutant;Mutation;Neurodevelopmental Disorder;neuronal circuitry;Neurons;novel;Pathway interactions;Phenotype;Physiology;reproductive;Research;Research Proposals;risk variant;social;social attachment;Social Behavior;social defeat;social engagement;Social Interaction;Societies;Specific qualifier value;Study models

PROJECT_TITLE: Epigenetic control of behavior


ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative:  Our research aims to design new protocols that enable sustainable access to a range of nitrogenated compounds. Specifically, the installment of amines, amides and nitriles is targeted due to the ubiquity of these groups in biologically active molecules, commercial drugs, and their versatility as synthetic building blocks. From a broader perspective, it is expected that this work will contribute to an increase in the use of Ni-mediated transformations in industrial and academic lab settings by designing protocols that are easily scalable and avoid using toxic reagents.

PI_NAMEs: BAHAMONDE, ANA  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Ni-catalyzed sustainable and scalable approaches to nitrogenated compounds


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Hearing Loss;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative Hearingloss has been reported in 37% of people living withAlzheimer's disease (AD), a global health crisis with no cure. The link between these two pathologies has not been established and it is not known if hearing loss and AD share a common underlying mechanism. Completion of this project will establish if tissue-resident macrophage populations in the cochlea and microglia in the brain are the common pathological link between hearing loss and AD.

PI_NAMEs: AJAMI, BAHAREH  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: abeta accumulation;Acceleration;Acute;Affect;Age;age group;aged;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;amyloid pathology;angiogenesis;Animals;Anti-Inflammatory Agents;Auditory area;auditory pathway;Brain;brain tissue;Cell Separation;Cells;Centers for Disease Control and Prevention (U.S.);Cerebellum;Clinic;Clinical Trials;Cochlea;cost;cytokine;Data;Dementia;Development;Disease;Disease associated microglia;Disease Progression;drug development;Drug or chemical Tissue Distribution;effective therapy;Environment;epidemiology study;Event;Failure;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Transcription;genome wide association study;Genomics;global health;Hair Cells;Healthcare;hearing impairment;Heterogeneity;Human;Human Genome;hyperphosphorylated tau;Immune;Impaired cognition;Individual;Inflammatory;Inflammatory Response;Late Onset Alzheimer Disease;Link;Macrophage;Mediator;Microglia;Molecular;mouse model;Mus;Myelogenous;Myeloid Cells;National Institute on Deafness and Other Communication Disorders;Nerve Degeneration;neuronal circuitry;Neurons;Noise;Noise-Induced Hearing Loss;normal hearing;old mice;parent grant;parent project;Parents;Pathogenesis;Pathologic;Pathology;Pathway interactions;Persons;Phenotype;Play;Population;Property;Recovery;Reporting;Research;research and development;Research Personnel;risk variant;Role;Senile Plaques;Series;sex;Shapes;single-cell RNA sequencing;Site;Sorting;Spatial Distribution;Surveys;Susceptibility Gene;Synapses;synaptic pruning;Testing;theories;Therapeutic;therapeutic target;therapy development;Tissue-Specific Gene Expression;Tissues;TREM2 gene;Variant;Vascular Diseases;Work

PROJECT_TITLE: Investigating the immune phenotype and functional properties of macrophage populations in the cochlea of Alzheimer’s disease model


NIH_SPENDING_CATS: Adolescent Sexual Activity;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Intimate partner sexual violence (IPSV) is a significant public health problem; however, research is needed to understand how and among whom ISPV is most likely to occur. By accounting for effects at both the individual- and couple-level in sexual minority and heterosexual couples, this study will be the first to determine (1) how alcohol intoxication and sexual communication predict IPSV perpetration in laboratory and real-world contexts and (2) the temporal relationship between alcohol use and IPSV. Results from this study will directly inform an etiological framework on IPSV, from which researchers and clinicians can develop programs to curb rates of alcohol-related IPSV among sexual minority and heterosexual couples.

PI_NAMEs: LEONE, RUSCHELLE MARIE (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Accounting;Acute;Address;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol measurement;alcohol testing;Alcoholic Intoxication;Alcohols;Beverages;binge drinking;cis-male;cisgender;Communication;Consent;contextual factors;Couples;design;drinking;Drug usage;Etiology;Event;evidence base;Exclusion;experience;Female;Future;Goals;Heavy Drinking;Heterosexuals;Homicide;Individual;insight;Intervention;intervention program;intimate partner violence;Laboratories;Literature;longitudinal design;male;man;Measures;member;men;Mental Health;Modeling;non-verbal;Outcome;Participant;Partner Communications;partner violence;Pattern;perpetrators;prevent;Probability;programs;psychologic;psychological violence;Public Health;Randomized;Recording of previous events;recruit;Reporting;Research;Research Personnel;response;Risk;Role;sex;sexual minority;sexual minority group;Sexual Partners;sexual violence;Testing;Theoretical model;Time;verbal;violence perpetration;violence victimization;Woman

PROJECT_TITLE: Determining the Proximal and Temporal Effects of Alcohol and Sexual Communication on Intimate Partner Sexual Violence among Sexual Minority and Heterosexual Couples

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Genetics;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Traumatic Head and Spine Injury

PHR: Project Narrative In this proposal, we will use freshwater planarians (flatworms) and zebrafish to understand the roles of the ELMO pathway in the clearance of dying cells in adult tissue turnover and injury regeneration. We will identify the engulfing cell types and molecular pathways needed for adult dying cell clearance, then determine how altering cell death and corpse clearance function to ensure successful regeneration.

PI_NAMEs: PEARSON, BRET JAMES (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Ablation;Acute;Adult;adult stem cell;Affect;Animals;Autoimmune;Autoimmune Diseases;Back;Biological Assay;Biological Models;Birth;cell behavior;Cell Death;Cell Death Induction;cell motility;Cell Motility Pathway;Cell Physiology;Cell Proliferation;cell regeneration;cell type;Cells;Clear Cell;Data;Defect;Development;Disease;Electron Microscopy;Ensure;epithelial stem cell;Excision;Excretory function;Face;Feedback;Feeds;Fresh Water;gene discovery;gene function;Genes;Genetic;genetic analysis;Genetic Models;Homeostasis;Homologous Gene;Human;human disease;Image;Immune;improved;in vivo;in vivo regeneration;Inflammation;Inflammatory;Injury;Link;Locomotion;Macrophage;Mammals;mature animal;Measures;member;Methods;Modeling;Molecular;Molecular Genetics;mutant;Natural regeneration;neutrophil;Normal Cell;novel;Organism;Orthologous Gene;Outcome;paralogous gene;Pathway interactions;Pattern;Peripheral;Phagocytes;Phagocytosis;Physiological;Pigments;Planarians;Platyhelminths;Play;Process;Proliferating;Publishing;Recovery;Recovery of Function;regeneration model;regenerative;regenerative biology;Regenerative research;Research;Rheumatoid Arthritis;RNA Interference;Role;Scanning;Signal Transduction;Spinal Cord;Spinal cord injury;spinal cord regeneration;Spinal Cord transection injury;stem cell biology;stem cell proliferation;stem cells;Systemic Lupus Erythematosus;Testing;Tissues;tool;transcriptome sequencing;Transgenic Organisms;tumorigenesis;Visualization;Work;Zebrafish

PROJECT_TITLE: Mechanisms of cell corpse clearance in tissue turnover and regeneration using planarians and zebrafish

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Digestive Diseases;Immunization;Immunotherapy;Nanotechnology;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative [Parent project] Pancreatic cancer is one of the most deadly malignancies in the United States. In this highly collaborative study, a multidisciplinary team of investigators from the University of California at Davis, TargaGenix and Northeastern University, will collaborate to develop a clinically translatable nanoemulsion-based delivery system for our lead agent in combination with immunotherapy for effective treatment of pancreatic tumors. The proposed solution will lead to the development of a promising new combination anticancer therapeutic modality, especially against aggressive and highly metastatic diseases, such as pancreatic cancer.

PI_NAMEs: AMIJI, MANSOOR M.;EGAN, JAMES E;KIM, EDWARD J;MACKENZIE, GERARDO GUILLERMO (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: 3-Dimensional;Abraxane;Acids;advanced pancreatic cancer;Affect;Animal Model;anti-cancer therapeutic;anti-PD-L1;anti-PD-L1 antibodies;anti-PD-L1 therapy;Antibody Therapy;Biodistribution;California;cancer immunotherapy;Canis familiaris;CD8-Positive T-Lymphocytes;checkpoint inhibition;chemotherapy;Clinical;clinical development;Clinical Research;clinical translation;Clinical Treatment;Clinical Trials;clinically relevant;Collaborations;Combined Modality Therapy;cytotoxicity;Data;Dedications;density;Development;Diagnosis;Disease;Docosahexaenoic Acids;Dose;Drug Combinations;Drug Kinetics;effective therapy;efficacy evaluation;Evaluation;experience;Fibrosis;Formulation;Foundations;Future;gemcitabine;Genetically Engineered Mouse;Goals;Growth;Human;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;immunogenic;Immunotherapy;improved;improved outcome;In Vitro;in vivo;Industry;industry partner;innovation;interest;KPC model;Lead;lead candidate;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Mission;Modality;Modeling;multidisciplinary;multimodality;nanoemulsion;nanomedicine;Nanotechnology;next generation;novel;novel therapeutic intervention;novel therapeutics;Oils;Organoids;Paclitaxel;Pancreas Transplantation;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;parent grant;parent project;Patients;personalized medicine;Pharmaceutical Preparations;Phase I Clinical Trials;Polyunsaturated Fatty Acids;Pre-Clinical Model;Qualifying;rational design;Rattus;Refractory;Research Personnel;Safety;Scientist;Stromal Neoplasm;System;T cell infiltration;Taxoids;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;Time;Toxic effect;Toxicology;translatable strategy;Treatment Efficacy;Treatment outcome;treatment strategy;tumor;tumor growth;United States;Universities;Unresectable;Water

PROJECT_TITLE: TGX-1214 - Combination strategy for the treatment of advanced pancreatic cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(57)-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Chronic Liver Disease and Cirrhosis;Clinical Research;Dementia;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROEJCT NARRATIVE In the Multiethnic Cohort (MEC) based in Hawaii and Los Angeles, the risk of Alzheimer's disease and related dementias (ADRD) showed a two-fold difference by race/ethnicity; highest among African Americans and Native Hawaiians, lowest in Asian Americans, and intermediate in Latinos and Whites. Emerging evidence suggests that non-alcoholic fatty liver disease (NAFLD), detected in over 30% of older adults, increases the risk of ADRD, and that pro-inflammatory gut microbiota may be involved in the liver-brain connection. We propose to evaluate whether ADRD risk is higher among NAFLD patients in MEC, whether the exclusive blood marker for microbial inflammation is related to the blood marker for brain inflammation, and whether and how gut microbial characteristics (diversity, composition, functions) are related to the blood marker for brain inflammation.

PI_NAMEs: HULLAR, MEREDITH ;LAMPE, JOHANNA W;LIM, UNHEE  (contact)

PROJECT_TERMS: Administrative Supplement;Adult;African American population;age difference;aged;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Applications Grants;Archives;Asian;Asian Americans;Base Sequence;beta diversity;Biological Markers;Blood;Blood specimen;Body Weight decreased;Brain;Characteristics;chronic liver disease;clinical biomarkers;cohort;Data;Data Analyses;Dementia;dementia risk;Diagnosis;Diagnostic;Diet;Disease Progression;Disparate;Encephalitis;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;Etiology;European;experience;Fatty acid glycerol esters;follow-up;Frequencies;gene function;Genetic Carriers;Glial Fibrillary Acidic Protein;gut health;gut microbiome;gut microbiota;Hawaii;high risk;improved;Inflammation;Inflammatory;Intervention;Latino Population;lifestyle intervention;Link;lipopolysaccharide-binding protein;Liver;Liver Fibrosis;longitudinal analysis;Longitudinal Studies;Longterm Follow-up;Los Angeles;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Medicare;Medicare claim;men;microbial;multi-ethnic;National Institute on Minority Health and Health Disparities;Native Hawaiian;Nerve Degeneration;Nested Case-Control Study;neuroinflammation;non-alcoholic fatty liver disease;non-genetic;novel;Obesity;older adult;Outcome;parent project;Parents;Participant;Pathway interactions;Patients;Phenotype;Plasma;Population;Population Attributable Risks;population based;population health;Predisposition;prevent;prospective;Race;racial difference;racial disparity;racial minority;racial population;Recording of previous events;Reporting;Resolution;response;Risk;Risk Adjustment;Risk Factors;risk variant;Role;rRNA Genes;Rural Population;tau Proteins;Testing;timeline;Woman

PROJECT_TITLE: Longitudinal Study of Early NAFLD Progression and the Gut Microbiome in Asian Americans, Native Hawaiians and Whites

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Public Health Relevance Colorectal cancer (CRC) is common and deadly, but screening has been demonstrated to reduce incidence and mortality. Federally Qualified Health Centers (FQHCs) are government-funded primary care facilities that frequently use stool-based CRC screening tests that are effective yet require colonoscopy follow-up when results are abnormal. The proposed study will evaluate the impact of a multilevel, multicomponent intervention on follow-up colonoscopy rates after abnormal screening test results in a large FQHC with low colonoscopy follow-up rates.

PI_NAMEs: GLENN, BETH A.;MAY, FOLASADE POPOOLA (contact)

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: Address;Cancer Burden;Cancer Control Research;Cancer Etiology;care coordination;Caring;Clinic;Clinical;clinical practice;Cluster randomized trial;Colon;Colonoscopy;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;compare effectiveness;comparison intervention;Complex;Comprehensive Health Care;Cost Measures;Country;County;design;Diagnostic;Early Diagnosis;effectiveness testing;effectiveness/implementation trial;Elements;ethnic diversity;Face;Feces;Federally Qualified Health Center;follow-up;Funding;Gastroenterologist;Gastroenterology;Government;Health;health care delivery;Health care facility;health care settings;Health system;Hospitals;Hybrids;implementation intervention;improved;Incidence;incremental cost-effectiveness;Individual;Infrastructure;innovation;Intervention;intervention cost;intervention effect;Literature;Los Angeles;Low income;Malignant Neoplasms;Measures;medical specialties;medically underserved population;Methods;Minority Groups;Modality;mortality;multi-component intervention;Multilingualism;neighborhood safety;Outcome;patient navigation;patient oriented;patient subsets;Patients;Population Heterogeneity;Prevention;Primary Care;primary care provider;primary care setting;primary outcome;Privatization;Process;Provider;public health relevance;racial diversity;Randomized;Rectal Polyp;Research;Resolution;Resource-limited setting;Resources;Risk;safety net;screening;Screening Result;Services;Site;Specialist;System;Test Result;Testing;treatment as usual;trial design;Underserved Population;United States;United States Department of Veterans Affairs;uptake

PROJECT_TITLE: Evaluating a Multilevel Intervention to Increase Colonoscopic Follow-up after Abnormal Stool-based Colorectal Cancer Screening in a Community Safety-Net Setting

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Rare Diseases

PHR: PI: Mitra, Sharmistha Project Narrative Amylopectinosis is a process by which soluble glycogen becomes insoluble and precipitates into toxic aggregates in tissues. Linear ubiquitin chain assembly complex (LUBAC) controls glycogen solubility and the absence of it results in life claiming polyglucosan body myopathy-1 disease. Our work is set to uncover the mechanisms through which LUBAC controls glycogen solubility with the expectation of insights into the treatments for this rare condition as well as other common adult diseases where both LUBAC and glycogen are known to play critical roles.

PI_NAMEs: MITRA, SHARMISTHA  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 1 year old;Adaptor Signaling Protein;Adult;Alzheimer's Disease;Amylopectin;Architecture;BACH1 gene;Binding;Brain;brain cell;Carbohydrates;Cardiomyopathies;Cell Line;Cell model;Cells;Central Nervous System;Complex;Dedications;Deposition;Disabling;Disease;Embryo;Ensure;Enzymes;Exhibits;expectation;experimental study;Gene Expression;Genes;Genetic Transcription;Glucose-6-Phosphate;Glycogen;Glycogen (Starch) Synthase;glycogen metabolism;Glycogen Storage Disease Type IV;glycogen synthase kinase 3 beta;glycogenesis;Growth;Heart;Heart failure;HK2 gene;Homeostasis;Impaired cognition;In Vitro;in vivo;Inflammatory;inorganic phosphate;insight;Knock-out;Knockout Mice;Knowledge;Lafora Disease;Lead;Life;Linear Models;Link;Liver;macromolecule;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Methionine;Methods;Modeling;Molecular;Molecular Weight;Motor;Motor Neurons;mouse model;Multiprotein Complexes;Mus;Muscle;Muscle Cells;Muscle Weakness;mutant;Mutation;Myocardium;Myopathy;Nerve Degeneration;neuroinflammation;neuron loss;novel;novel strategies;Organ;overexpression;Pathology;Pathway interactions;Patients;Peptides;Play;polyglucosan;Precipitation;Process;protein aggregation;Proteins;Proteomics;Publishing;Radial;rare condition;Rare Diseases;recruit;Research;Role;Secure;sharpin;skeletal;Skeletal Muscle;Solubility;Specificity;Starch;STAT3 gene;Structure;Testing;Tissues;transcription factor;transcriptome;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Uncovering the Mechanisms of Amylopectinosis in LUBAC Deficiency

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Bipolar Disorder;Brain Disorders;Clinical Research;Data Science;Depression;Genetics;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Serious Mental Illness;Social Determinants of Health

PHR: PROJECT NARRATIVE The mission of the PsycheMERGE Network is to advance equitable precision psychiatry in learning healthcare system frameworks across the United States. During the course of this project, an interdisciplinary team of investigators at twelve academic medical centers will bring together clinical data (>29 million individuals), genetic data (>1.9 million), and an extraordinary range of scientific expertise (psychiatry, medical informatics, machine learning, statistics, genetics, sociomedical sciences, decision sciences, and ethics) to advance this mission. We will leverage this expertise and data to build on our prior success and address barriers to scalability, utility of genomic data, clinical application, and translation to clinical practice.

PI_NAMEs: OLDE LOOHUIS, LOES MARLEIN (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Academic Medical Centers;acceptability and feasibility;Acute;Address;algorithm training;Algorithms;anti-depressive agents;Artificial Intelligence;artificial intelligence method;Attitude;Awareness;Basic Science;Big Data;biobank;Biology;Biomedical Research;Bipolar Disorder;Bipolar I;causal variant;Clinical;clinical application;Clinical Data;clinical decision support;clinical practice;Communities;Country;Data;data privacy;depressive symptoms;Development;Diagnosis;Diagnostic;Differential Diagnosis;disability;Disease;Early Diagnosis;Early treatment;effective therapy;Effectiveness;Environment;Equity;Ethics;experience;federated learning;Funding;Genes;Genetic;genetic analysis;genetic association;genome wide association study;genome-wide;genomic data;Genomics;Goals;Grant;Health system;Healthcare Systems;improved;Individual;individual variation;Infrastructure;innovation;Label;large scale data;Learning;Left;Life Style;Machine Learning;machine learning algorithm;Maps;Medical;Medical Informatics;Medical Records;member;Mental disorders;Methods;Midwestern United States;Mission;Modeling;Mood Disorders;Morbidity - disease rate;mortality;National Institute of Mental Health;network models;novel;Outcome;Patients;Pattern;Performance;Phenotype;Population;precision medicine;predicting response;Prediction of Response to Therapy;Prevention;privacy preservation;Process;Psychiatric Diagnosis;Psychiatry;Records;Research Personnel;response;risk prediction;Sampling;Science;Scientist;Site;social health determinants;Standardization;statistics;Strategic Planning;success;support tools;Testing;Time;tool;Training;transfer learning;Translational Research;Translations;treatment response;United States;Update;Validation;Vision;Work

PROJECT_TITLE: 5/7-PsycheMERGE: Advancing Precision Psychiatry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-D (65)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: SAN DIEGO

ORG_NAME: SCINTILLON INSTITUTE FOR PHOTOBIOLOGY

PHR: PROJECT NARRATIVE We propose to correlate single cell epigenetic changes in AD brain spectrum with gene expression and functional readouts of cognitive decline.

PI_NAMEs: TERSKIKH, ALEXEY V (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: 3-Dimensional;Age;Aging;aging biomarker;aging brain;aging process;Alzheimer's Disease;Alzheimer's disease related dementia;antibody conjugate;ATAC-seq;Autopsy;Biological Assay;Brain;brain cell;Cell Lineage;cell type;Cells;Chromatin;Chronology;Classification;Clinical Trials;cognitive function;cohort;combinatorial;Communities;Confocal Microscopy;Data;Data Set;Dependence;digital repositories;Disease Progression;Early Diagnosis;Epigenetic age;Epigenetic Process;feature extraction;Free Association;Future;Gene Expression;gene function;Genes;Heterogeneity;histone modification;Human;Image;imaging approach;Immunofluorescence Immunologic;Impaired cognition;improved;Individual;Information Dissemination;Joints;Laboratories;large datasets;Machine Learning;Maps;Methods;Molecular;multimodal data;normal aging;novel;Nuclear;Oligonucleotides;Organism;Pathologic;Pattern;Peer Review;Peripheral Blood Mononuclear Cell;Phenotype;Physiological;Prefrontal Cortex;prenatal;preservation;Publications;Pythons;Research;response;Sampling;SDZ RAD;single-cell RNA sequencing;Skeletal Muscle;Techniques;Technology;Testing;Texture;timeline;Tissue Sample;tool;transcriptome sequencing;young adult

PROJECT_TITLE: Testing the utility of miBioAge as a personalized aging biomarker

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]