NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Prevention

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative About 10% of older bereaved adults will develop Prolonged Grief Disorder, a psychiatric condition associated with significant impairment that, if left untreated, is associated with adverse health outcomes. We will examine the prevalence, risk, and protective factors associated with PGD in the Nurses’ Health Study, Nurses' Health Study 2, and Health Professionals Follow-up Study, which are large, longitudinal cohorts of older populations at risk of bereavement. Results will deliver insights into risk and protective factors that can inform primary prevention efforts for the millions of older adults currently at risk of PGD, generating evidence to guide strategic bereavement care that addresses this looming public health problem.

PI_NAMEs: DENCKLA, CHRISTY ANN (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Address;Adult;adverse outcome;Age;behavior change;Behavioral;Bereavement;Bereavement Care;Biological;Biological Markers;candidate identification;Categories;Cause of Death;Cessation of life;Characteristics;Chronic Disease;Clinical;clinically significant;cohort;Data;Data Science;Diagnostic;Disease;DSM-V;effective therapy;efficacious intervention;Enrollment;Epidemiology;Excess Mortality;experience;Face;follow-up;Follow-Up Studies;Funding;Future;Genetic;Genetic Risk;Goals;Grief reaction;Health;Health Professional;high risk;human old age (65+);immune function;Impairment;improved;indexing;Individual;Infrastructure;insight;International Classification of Diseases;Interview;Knowledge;Left;Letters;Longitudinal cohort;Longitudinal Studies;loved ones;Machine Learning;Major Depressive Disorder;Manuals;Mental Depression;Mental disorders;Mental Health Services;Modeling;modifiable risk;mortality risk;multiple chronic conditions;National Institute of Mental Health;novel;Nurses' Health Study;older adult;Older Population;optimism;Outcome;Pathway interactions;Physical activity;Physiological;polygenic risk score;Population;Populations at Risk;Post-Traumatic Stress Disorders;Prevalence;Prevention;Primary Prevention;Probability;prospective;protective factors;psychologic;Psychopathology;psychosocial;Psychosocial Factor;Public Health;Quality of life;Questionnaires;Recording of previous events;Religiosity;Resources;response;Risk;Risk Factors;Sampling;Science;Services;sex;Sex Differences;Sleep disturbances;Social support;Structure;suicidal;Surveys;Symptoms;Testing;Text;Time;United States National Institutes of Health;Work

PROJECT_TITLE: Death of a loved one: Prevalence, risk, and protective factors for prolonged grief disorder

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: LM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Autism;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Precision Medicine

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Newly available large-scale human neurobiological data offer an unprecedented opportunity for biologically- grounded, data-driven stratification of psychiatric disorders—a major public health concern. The goal of this proposal is to develop and validate a novel computational framework for the identification, validation, and characterization of biological subtypes of psychiatric disorders using large-scale human brain imaging, phenotypic, and transcriptomic data, and to apply the framework to the study of autism. The framework developed here can be extended to examine other psychiatric disorders and can enable the development of more effective and precise diagnostic and treatment strategies for the disorders.

PI_NAMEs: SUPEKAR, KAUSTUBH SATYENDRA (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: 22q11;Acceleration;autism spectrum disorder;Biological;Brain;Brain imaging;Clinical;cohort;computer framework;Computing Methodologies;Data;Data Analytics;Development;Diagnosis;diagnostic strategy;Disease;Disease Progression;Disease stratification;effective therapy;Etiology;Fingerprint;Gene Expression;generative models;Genes;Glean;Goals;Health;Heterogeneity;Human;improved;improved outcome;Individual;Investigation;Knowledge;Machine Learning;machine learning algorithm;Malignant Breast Neoplasm;Mental disorders;Methods;Modeling;Modern Medicine;neural;Neurobiology;novel;open source;personalized diagnostics;Phenotype;phenotypic data;precision medicine;Procedures;Public Health;repository;Reproducibility;Research;Sampling;Signs and Symptoms;Space Models;Strategic Planning;Stratification;transcriptomics;translational impact;treatment response;treatment strategy;United States National Institutes of Health;United States National Library of Medicine;Universities;unsupervised learning;Validation;Work

PROJECT_TITLE: Identifying, Validating, and Characterizing Biological Subtypes of PsychiatricDisorders Using a Novel Computational Framework

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Nanotechnology;Prostate Cancer;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative Androgen receptor inhibition remains the most effective and among the least toxic interventions used to effectively control advanced prostate cancers. Reversing and even preventing resistance is of the highest importance to patients and clinicians given the lack of desirable, alternative treatment options. This proposal will develop a novel means of regulating androgen receptor inhibition sensitivity by modulating biochemical signaling in the microenvironment with a non-toxic agent that has entered clinical development.

PI_NAMEs: BHOWMICK, NEIL A. (contact);POSADAS, EDWIN MELENCIO

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: abiraterone;Accounting;advanced prostate cancer;Affect;Aftercare;alternative treatment;androgen independent prostate cancer;Androgen Receptor;Androgens;antagonist;Appearance;Behavior;Biochemical;Biology;Blood;Bone Marrow;Bone Morphogenetic Proteins;Cancer Etiology;Cancer Patient;Carcinoma;Cell Nucleus;Cells;Cellular Morphology;Cessation of life;Clinical;clinical development;Combined Modality Therapy;Development;Disease Progression;Disease Resistance;disorder control;ENG gene;enzalutamide;Epithelium;experimental study;FGF8 gene;FGFR3 gene;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Fibroblasts;Frequencies;Gene Expression;genetic signature;genomic profiling;Genomics;Glutamine;Goals;improved;inhibitor;inhibitor therapy;innovation;insight;Interruption;Intervention;Malignant neoplasm of prostate;Malignant Neoplasms;Mediator;men;Modification;Molecular Analysis;Monitor;Morphology;mortality;Mus;Nanotechnology;nanotechnology platform;NanoVelcro;Neoplasm Circulating Cells;neoplastic cell;Neuroendocrine Cell;neuroendocrine phenotype;neutralizing antibody;next generation;novel;paracrine;Paracrine Communication;patient derived xenograft model;Patient Selection;Patients;Pharmacodynamics;phase 2 study;phase II trial;Pre-Clinical Model;Predictive Value;prevent;primary endpoint;Prognosis;prognostic value;programs;prospective;Prostate;prostate cancer cell;Prostatic Epithelium;Quality of life;radiological imaging;Randomized;randomized, clinical trials;Receptor Inhibition;Receptor Signaling;Reporting;Resistance;Resistance development;resistance mechanism;response;RNA Splicing;Role;Sampling;Selection Criteria;serum PSA;Signal Transduction;Signaling Protein;synthetic lethal interaction;System;targeted treatment;Technology;Testing;therapeutic development;therapy resistant;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;translational approach;translational study;treatment response;tumor;Tumor Expansion;tumor microenvironment;tumor progression;tumorigenic;Up-Regulation;Variant

PROJECT_TITLE: A translational study of a synthetic lethality interaction of CD105 and androgen receptor signaling axis for castration-resistant prostate cancer patients

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Cancer;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Chronic lymphocytic leukemia (CLL) and related non-Hodgkin lymphomas (NHL) account for a high number of patients with cancer. Bruton’s tyrosine kinase (BTK) inhibitors have transformed the therapeutic landscape for patients; however, resistance to BTK inhibitors emerge on monotherapy and the mechanisms are incompletely understood. This project aims to identify the specific mechanisms underlying resistance to non-covalent BTK inhibitors and to identify the genomic basis for BTK inhibitor resistance.

PI_NAMEs: TAYLOR, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Agammaglobulinaemia tyrosine kinase;B lymphoid malignancy;B-Cell Antigen Receptor;B-Cell Development;B-Cell Lymphomas;Binding;Cell Survival;Cells;Chronic Lymphocytic Leukemia;Clinical;clinical efficacy;Clinical Trials;Cysteine;Data;Dependence;design;Disease;DNA Sequence Alteration;Drug resistance;early phase clinical trial;FDA approved;functional genomics;Future;Genomics;Goals;Impairment;in vivo;Incidence;inhibitor;Laboratories;Malignant Neoplasms;Mantle Cell Lymphoma;Molecular;Monitor;Mus;mutant;Mutation;Non-Hodgkin's Lymphoma;novel;novel therapeutics;Oncogenes;Outcome;Patients;Pharmaceutical Preparations;Phosphotransferases;PLCG2 gene;Predisposition;prevent;Protac;protein degradation;Proteins;Receptor Signaling;Recurrence;Refractory;Relapse;Reporting;Resistance;Resistance development;resistance mechanism;resistance mutation;response;Role;scaffold;Signal Pathway;Signal Transduction;small molecule inhibitor;small molecule therapeutics;targeted treatment;Testing;Therapeutic;Tyrosine Kinase Inhibitor;ubiquitin ligase;Ubiquitination

PROJECT_TITLE: Understanding mechanisms of BTK inhibitor and degrader resistance in patients with chronic lymphocytic leukemia

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Human Genome;Pediatric;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: CAMBRIDGE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative The capacity to regenerate complex organs varies greatly at different stages of development. Using skin as a model, we aim to identify genes that can functionally drive multi-lineage regeneration or scarring responses after wounding. These results are not only important for the mechanistic understanding of regeneration, but may also provide innovative therapeutic solutions to advance treatment strategies for wound healing.

PI_NAMEs: HSU, YA-CHIEH  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Adipocytes;Adult;Affect;Age;Animals;Atlases;Biological Assay;Blood Vessels;Burn injury;cell regeneration;Cell Separation;cell type;Cells;Chromatin;Chronic;Cicatrix;Complex;Data;Dependovirus;Dermal;Development;differential expression;Digit structure;Endowment;Environment;Epidermis;Exhibits;experimental study;fascinate;fetal;Fetal Development;Fibroblasts;Fibrosis;Foundations;Future;gene discovery;Gene Expression;Genes;Genetic;Genetic Enhancer Element;genetic manipulation;genetic signature;Genomics;Goals;hair erector muscle;Hair follicle structure;healing;Heart;Image;Immunofluorescence Immunologic;improved;in utero;in vivo;Injury;innovation;insight;lymphatic vessel;Mammals;Modeling;Molecular;Morphology;multiple omics;Mus;Muscle;Natural regeneration;Neonatal;nerve supply;non-healing wounds;novel therapeutic intervention;Operative Surgical Procedures;Organ;Outcome;overexpression;Population;Positioning Attribute;postnatal;Pregnancy;Process;programs;Protocols documentation;regeneration potential;regenerative;Regenerative capacity;regenerative healing;Regenerative Medicine;Regenerative response;Research;response;RNA;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Skin;skin healing;Skin injury;skin regeneration;skin wound;Skin wound healing;Solid;stem cells;Stromal Cell-Derived Factor 1;Temperature;Testing;Therapeutic;Thick;Tissues;tool;Touch sensation;transcriptome;transcriptome sequencing;Transplantation;treatment strategy;Uterus;UV Radiation Exposure;Viral;Viral Vector;Wild Type Mouse;Work;wound;wound healing;XCL1 gene

PROJECT_TITLE: Mechanisms of Fetal Skin Regeneration

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DALLAS

ORG_DEPT: SURGERY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Though critical in the healing process, our understanding of how local inflammation following extremity trauma is linked to the systemic immune response in the bone marrow is still poorly understood. Here, we propose a new paradigm where itaconate is synthesized at the injury site and trafficked back to the bone marrow by cycling neutrophils to regulate hematopoiesis. This proposal will establish a new mechanism by which the body coordinates the distant local injury site to the systemic immune response.

PI_NAMEs: TOWER, ROBERT  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Affect;Automobile Driving;Back;Biology;Blood;Bone Marrow;Cell Communication;Cell Lineage;Cells;Citric Acid Cycle;Communication;conditional knockout;Coupling;cytokine;Data;Distant;Environment;Extravasation;Failure;Fibrosis;Gene Expression;Genetic Transcription;Glucose;Glutamine;granulocyte;healing;Hematopoiesis;Hematopoietic;hematopoietic stem cell differentiation;Hematopoietic stem cells;Heterotopic Ossification;Histologic;Home;Immune;Immune response;immunoregulation;Impairment;Infiltration;Inflammation;Inflammatory;Inflammatory Response;injured;Injury;Innate Immune Response;insight;Interleukin-1 beta;Knockout Mice;Ligands;limb injury;Link;Macrophage;Malignant Neoplasms;Maps;Membrane;Metabolic;Metabolism;metabolomics;Modeling;Molecular;monocyte;Multiple Trauma;musculoskeletal injury;Myelogenous;Nature;neutrophil;novel;Oxidative Phosphorylation;Phagocytosis;Process;Production;receptor;Regulation;remote sensor;repaired;response;response to injury;Role;sensor;Signal Transduction;single-cell RNA sequencing;Site;small molecule inhibitor;Stimulus;systemic inflammatory response;Testing;Tissues;Titrations;TLR9 gene;Toll-like receptors;Tracer;Transgenic Mice;Trauma;Validation;Work

PROJECT_TITLE: Neutrophil Metabolism Regulates Hematopoiesis After Trauma

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Mark Ilgen, Ph.D. is a productive Department of Veterans Affairs Health Services Researcher who is recognized nationally as a leader in the area of Addiction Health Services Research and is dedicated to improving care for Veterans with Substance Use Disorders (SUDs). His work is designed to enhance positive treatment outcomes and reduce potential adverse events for Veterans with SUDs, particularly for those who have comorbid pain or who are at increased risk of suicide. The proposed Research Career Scientist Award will support his continued research to enhance care for Veterans, as well as an expanded role in mentorship and training of early career scientists as the next generation of VHA health services researchers and leaders.

PI_NAMEs: ILGEN, MARK A. (contact)

PROJECT_TERMS: abuse liability;addiction;Address;Adverse event;adverse event risk;Alcohols;Area;Award;behavioral health;brief intervention;Budgets;career;Caring;chronic pain;Clinical;clinical center;Clinical Management;Collaborations;Communities;comorbidity;Databases;Dedications;Department of Defense;design;Development;Doctor of Philosophy;Epidemiologist;Evaluation;evidence base;Family;Funding;Future;Grant;Health;Health Personnel;Health Services;Health Services Administration;Health Services Research;high risk;Homelessness;implementation study;Improve Access;improved;innovation;Institution;International;Intervention;Investments;Leadership;Link;Medical;member;Mental Health;Mentors;Mentorship;Methods;National Institute of Drug Abuse;next generation;Opioid;opioid epidemic;Outcome;Overdose;Pain;Pain management;Patients;Peer Review;Pharmaceutical Preparations;Physicians;Positioning Attribute;Productivity;Program Evaluation;Psychologist;Publications;Publishing;randomized trial;Research;research and development;Research Design;Research Personnel;Research Priority;Resources;Risk;Risk Factors;Risk Reduction;Role;Safety;Scientist;Services;severe mental illness;Site;Structure;Substance Use Disorder;suicidal risk;Suicide;Suicide prevention;System;telehealth;Testing;Training;Treatment outcome;United States National Institutes of Health;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: HSR&D Research Career Scientist Award

STUDY_SECTION_NAME: HSR-7 Capacity Building[HSR7]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Lung;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Disparities in uptake of the new Respiratory Syncytial Virus (RSV) vaccine by race/ethnicity will threaten potential public health gains from the vaccine. Through a community-based participatory research approach this study will focus on increasing RSV vaccine uptake among Latinos. In two trials we will determine the effectiveness of community health worker counseling and text-message interventions to (1) increase RSV vaccine uptake among older adults and (2) activate adults to discuss RSV vaccination with older adults in their social and family networks, while also gaining insights into the facilitators and barriers of these approaches.

PI_NAMEs: MARQUEZ, CARINA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Acute respiratory infection;Address;Adoption;Adult;Affect;arm;booster vaccine;Cessation of life;Communities;community academic partnership;community barrier;community based participatory research;Community Health Aides;Community Health Education;community intervention;community organizations;comparative effectiveness;Counseling;Coupled;COVID-19;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;Data;design;Development;Disparity;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation trial;empowerment;Enrollment;Equity;ethnic disparity;Ethnic Origin;evidence base;Family;flyer;Friends;grandchild;grandparent;Health;Health system;Hospitalization;implementation outcomes;improved;Income;Influenza;insight;Intervention;Intervention Studies;Knowledge;Language;Latino;Latino Population;Maintenance;marginalized community;Methods;Morbidity - disease rate;mortality;Motivation;multi-component intervention;novel vaccines;older adult;Outpatients;pandemic disease;Participant;Persons;primary outcome;Public Health;Race;racial disparity;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Resources;respiratory;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Syncytial Virus Vaccines;respiratory virus;secondary outcome;Site;social;Social Network;Techniques;Text Messaging;text messaging intervention;Time;Translating;trial design;Trust;two-arm trial;uptake;Vaccinated;Vaccination;vaccination strategy;vaccine acceptance;Vaccines;Virus Diseases;Visit;Work;young adult

PROJECT_TITLE: Motivate, Vaccinate, Activate’: An effectiveness-implementation trial to assess the impact of a multi-component community-based intervention to increase RSV vaccine uptake among Latino older adults

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHARLESTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: We have designed a 3D tissue chip which includes an RPE monolayer sitting on a perfusable choroid containing anastomosed endothelial cells, fibroblasts and pericytes which eventually form a BrM to complete the structure. This proposal will utilize this model to characterize the responses of the RPE- choroid to various stressors under the influence of the CFH and ARMS2/HTRA1 risk genotypes.

PI_NAMEs: ATKINSON, JOHN ;HUH, DONGEUN ;ROHRER, BAERBEL  (contact);STAMBOLIAN, DWIGHT EDWARD

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Age related macular degeneration;Anastomosis - action;Apical;Biological;Biological Assay;Blood;Blood flow;Bruch's basal membrane structure;Cell Communication;Cell Line;cell type;Cells;Choroid;Chromosome 10;Chromosomes;Complement;Complement Activation;complement pathway;complement system;Complex;compstatin;Data;Deposition;design;Development;Disease;disease mechanisms study;Drusen;Endothelial Cells;Ensure;Environment;environmental stressor;Excision;experimental study;extracellular;Extracellular Matrix Proteins;extracellular vesicles;Fatty Acids;Fibroblasts;Future;Gene Expression Profile;Genetic;Genetic Heterogeneity;genetic risk factor;genetic variant;Genetic Variation;Genotype;Goals;Histology;Hydrogels;Immunohistochemistry;in vivo;induced pluripotent stem cell;Inflammatory;insight;Intervention;Investigation;Knowledge;Liquid substance;Membrane;Microfluidic Microchips;Microfluidics;Modeling;monolayer;Morphology;novel therapeutics;Organ;Organoids;Outcome;Pathology;Perfusion;Pericytes;pigment epithelium-derived factor;Predisposition;Proteins;Protocols documentation;Publishing;receptor;Resistance;response;Risk;Risk Factors;risk variant;Scanning Electron Microscopy;single-cell RNA sequencing;Smoke;Stream;Stress;stressor;Structure;therapeutic target;three-dimensional modeling;Time;Tissue Microarray;Tissue Model;tissue stem cells;Tissues;Vascular blood supply;Vascular Endothelial Growth Factors;wasting

PROJECT_TITLE: Assessment of the Complement Pathway in a RPE/choroid Tissue Chip

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Hospitalized children suffer harm from medical errors at a rate three times that of adults and depend on clinicians to exchange information with parents to identify and intercept errors. While access to information within clinical notes, which detail a child’s diagnoses, treatment and contingency plans, has prompted parents to identify safety concerns, less than 10% of parents access notes during their child’s hospital stay. The objective of this proposed multisite clinical trial is to evaluate the effect of Bedside Notes – a health IT intervention designed to improve parent note access and, in turn, parent engagement in safety concern reporting in the pediatric inpatient setting.

PI_NAMEs: KELLY, MICHELLE M (contact)

PROGRAM_OFFICER_NAME: SWIGER, JAMES

PROJECT_TITLE: Bedside Notes: A multicenter trial to improve family clinical note access and outcomes for hospitalized children

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Liver Disease;Skin Cancer

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Narrative Rational combinatorial approaches are urgently needed to enhance immune checkpoint inhibitor efficacy in patients with liver metastases. We have discovered that liver metastases siphon and delete tumor-specific T cells to cause systemic immunotherapy resistance, and moreover that ablative liver-directed radiotherapy can restore immune checkpoint inhibitor efficacy. Herein we propose to evaluate mechanisms of immunotherapy resistance in melanoma patients and preclinical melanoma models of liver metastases as well as mechanistically define how liver SBRT overcomes immunotherapy resistance.

PI_NAMEs: GREEN, MICHAEL DANIEL (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Address;Adenosine;Affect;Antigens;Apoptosis;biomarker development;cancer type;Caring;CD8-Positive T-Lymphocytes;Cell Count;Cell Physiology;Cell Survival;Circulation;Clinical;Colorectal;combinatorial;Combined Modality Therapy;Complement;Data;Disease;Functional disorder;Goals;Hepatic;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immune signaling;Immune Tolerance;Immunosuppression;Immunotherapy;improved;insight;ipilimumab;Lead;Liver;liver ablation;Macrophage;Measures;Melanoma;Melanoma patient;Metastasis Induction;Metastatic Melanoma;Metastatic Neoplasm to the Liver;Modeling;mouse model;Mus;Myelogenous;neutrophil;Nivolumab;novel;Parents;Patient Care;Patients;Peripheral;Population;pre-clinical;Pre-Clinical Model;Production;programs;prospective test;purine metabolism;Purines;Radiation therapy;Resistance;resistance mechanism;response biomarker;Role;Signal Transduction;T-cell diversity;T-Lymphocyte;Testing;Therapeutic;tumor;Tumor Immunity;tumor progression;Work

PROJECT_TITLE: Ablating Liver Metastases with SBRT to Enhance Immune Checkpoint Blockade in Melanoma

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Physical Rehabilitation;Rehabilitation;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Cardiac rehabilitation, a structured program combining exercise training and risk factor management, may improve the health of patients with heart disease, but few eligible patients in the US receive the therapy. The proposed research will use novel statistical methods to examine the effectiveness of in-person and virtual cardiac rehabilitation in diverse populations, produce personalized estimates of benefit, and project the long- term effect of cardiac rehabilitation on population health and healthcare costs. The results of this study will help patients, clinicians, and policymakers make informed decisions about cardiac rehabilitation, and equitably advance the health of millions of US adults living with heart disease.

PI_NAMEs: KAZI, DHRUV SATISH (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Acceleration;Address;Adherence;Adult;American;analytical method;beneficiary;Cardiac rehabilitation;Cardiovascular Diseases;Cardiovascular system;Centers for Disease Control and Prevention (U.S.);Characteristics;Clinical;clinical practice;Communities;Complex;copayment;cost;cost effectiveness;cost estimate;COVID-19 pandemic;Data;Data Set;Data Sources;diverse data;Economics;Effectiveness;effectiveness evaluation;Electronic Health Record;Eligibility Determination;Emergency department visit;Epidemiologic Methods;Equity;Ethnic Origin;Evaluation;Event;evidence base;Exercise;exercise training;experience;falls;follow-up;Fracture;Guidelines;Health;Health Benefit;Health Care Costs;Health Care Sector;Health Policy;Health system;Healthcare;Heart;Heart Diseases;Heart failure;Heart Valve Diseases;Heterogeneity;Home;Impact evaluation;improved;Individual;individualized medicine;insight;Insurance;interest;Intervention;Investments;Knowledge;large datasets;Link;Long-Term Effects;machine learning method;Medicare;men;Methods;Modeling;models and simulation;Modernization;Modification;Morbidity - disease rate;mortality;multidisciplinary;Myocardial Ischemia;novel;Outcome;Participant;patient home care;patient population;Patient Selection;Patient-Focused Outcomes;Patients;personalized care;Persons;Policies;Policy Maker;Population;population health;Population Heterogeneity;pragmatic trial;Prevention;programs;Psychosocial Assessment and Care;Quality-Adjusted Life Years;Quasi-experiment;Race;randomized trial;randomized, clinical trials;recruit;Registries;repository;Research;response;Risk;Risk Factors;rurality;Selection Bias;Sex Differences;sex disparity;shared decision making;socioeconomics;Statistical Methods;Structure;Supervision;telehealth;Time;time use;tool;treatment effect;Uncertainty;Uninsured Medical Expense;United States Centers for Medicare and Medicaid Services;uptake;valve replacement;Variant;Veterans Health Administration;virtual;Work

PROJECT_TITLE: Leveraging Large Linked Datasets and Novel Analytic Methods to Understand the Long-term Effectiveness and Value of Cardiac Rehabilitation in Understudied Populations

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Aortic stenosis (AS) is a progressive narrowing of the aortic valve that causes significant disability and premature mortality in older adults despite being treatable with a minimally invasive valve replacement procedure. The application proposes a multicenter randomized clinical trial evaluating a low-cost and practical artificial intelligence-based, 2-stage screening strategy for older adults that can detect advanced AS before the onset of symptoms. In addition, the concomitant challenge of a lack of a precision follow-up strategy for incidentally discovered early-stage aortic valve disease is addressed with a novel digital biomarker for AS progression that can define individuals at an elevated risk of rapid progression of AS.

PI_NAMEs: KHERA, ROHAN  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adopted;Adult;Affect;Aorta;Aortic Diseases;aortic valve;aortic valve disorder;aortic valve replacement;Aortic Valve Stenosis;Artificial Intelligence;Artificial Intelligence enhanced;artificial intelligence model;Biological Markers;Cardiac;Cardiology;Cardiovascular system;career;Caring;Clinical;Clinical Medicine;clinical practice;Clinical Trials;Cohort Studies;Communities;cost;Data;Data Science;deep learning;deep learning model;design;Detection;Devices;Diagnosis;Diagnostic tests;Digital biomarker;disability;Disease;Disease Progression;Doppler Echocardiography;Early Diagnosis;Echocardiography;Elderly;Electrocardiogram;Enrollment;Equipment;ethnic minority;Evaluation;exercise capacity;experience;follow-up;functional outcomes;Future;Geography;Geriatrics;Guidelines;health care availability;health care disparity;Health system;Heart failure;Heterogeneity;high risk;human old age (65+);Human Resources;Image;improved;indexing;Individual;Informatics;innovation;Institution;Intervention;Investigation;Lead;Longevity;Low Income Population;minimally invasive;Monitor;mortality;novel;novel strategies;observational cohort study;older adult;Operative Surgical Procedures;Outcome;Patients;personalized care;point of care;portability;Premature Mortality;Procedures;prognostication;progression risk;prospective;Prospective Studies;prospective test;Public Health;racial minority;randomized trial;randomized, clinical trials;Recommendation;Research Personnel;Retrospective Studies;Risk;Risk Adjustment;routine care;Sclerosis;screening;Sensitivity and Specificity;Severities;sociodemographics;Specificity;Symptoms;Technology;Testing;tool;Training;treatment strategy;trial comparing;ultrasound;Validation;valve replacement;wearable device;Work

PROJECT_TITLE: Deep learning enhanced detection and personalized monitoring of aortic stenosis - The DETECT-AS Study

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Estrogen;Urologic Diseases

PHR: PROJECT NARRATIVE SRD5A2 is a critical enzyme for prostatic development and growth. Little is known about why patients with benign prostatic hyperplasia (BPH) do not uniformly respond to SRD5A2 inhibitors. Building on our previous studies, we use an SRD5A2 null mouse model and human prostate tissues with BPH to identify a discrete subpopulation of prostate luminal epithelial cells that maintain prostate survival upon dihydrotestosterone restriction and their potential role in non-responsiveness to 5ARI.

PI_NAMEs: OLUMI, ARIA F;WANG, ZONGWEI  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 5 Alpha-Reductase Inhibitor;Adult;Affect;Age;Alternative Therapies;alternative treatment;androgenic;Androgens;animal data;Animals;Anterior;Apoptosis;Applications Grants;Benign Prostatic Hypertrophy;Bladder;Castration;Cell Survival;Cells;Clinical;Clinical Data;clinical translation;deprivation;Development;Disease;Effectiveness;Enzymes;epigenetic silencing;Epithelial Cells;Epithelium;ESR1 gene;estrogenic;Estrogens;Generations;Genes;Goals;Growth and Development function;Health;High Pressure Liquid Chromatography;High Prevalence;Hormonal;Human;In Situ;In Vitro;Individual;inhibitor;inhibitor therapy;Knockout Mice;Life Expectancy;Lobe;lower urinary tract symptoms;male;Maps;Mediating;Medical;men;Modeling;Molecular;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Obstruction;Operative Surgical Procedures;Organoids;Outcome;Oxidoreductase;Patients;pharmacologic;Phenotype;Population;Prevalence;PRKCA gene;Proliferating;Prostate;prostate biopsy;Prostatic;Prostatic Diseases;Proto-Oncogene Proteins c-akt;Refractory;repository;Research;Resistance;response;Role;Secondary to;Selective Estrogen Receptor Modulators;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Spatial Distribution;Stanolone;Steroids;Symptoms;System;Testosterone;Therapeutic;Therapeutic Effect;Tissues;Transcriptional Regulation;transcriptomics;Work

PROJECT_TITLE: Decreased SRD5A2 and Alternative Estrogen Signaling in Prostatic Cell Survival

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-W (04)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: ROCHESTER

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Overcoming the burden of tobacco use among Latinos, the largest minority group in the U.S., demands innovative, effective, accessible, culturally appropriate, and community-engaged solutions. In partnership with the Latinos Contra el Tabaco Community Advisory Board, we developed Actívatexto, an innovative mobile intervention that integrates four components: 1) a text messaging program that promotes both smoking cessation and physical activity, 2) wearable devices to monitor physical activity, 3) smoking cessation pharmacotherapy (i.e., nicotine replacement therapies), and 4) an online dashboard where the research team manages participants’ incoming and outgoing data from both the text messaging program and wearable devices. We will assess the efficacy of Actívatexto (Aim 1), the mediators of the presumed treatment effect (Aim 2), and the barriers and facilitators of its implementation (Aim 3).

PI_NAMEs: CARTUJANO, FRANCISCO  (contact)

PROJECT_TERMS: 2 arm randomized control trial;Abstinence;barrier to care;Behavior;behavior change;Behavioral;Black race;cigarette smoke;Communities;community advisory board;Cotinine;Counseling;Cuban;Cultural Sensitivity;dashboard;Data;Disparity;efficacy evaluation;Enrollment;experience;follow up assessment;health care availability;Healthcare Systems;Hybrids;implementation design;implementation/effectiveness;Individual;innovation;interest;Intervention;Interview;Knowledge;Latino Population;Mediator;men;Methods;Minority Groups;Modeling;moderate-to-vigorous physical activity;Monitor;Motivation;multidisciplinary;nicotine replacement;Participant;perceived stress;Pharmacotherapy;Physical activity;Physical assessment;pilot test;Population;Prevalence;Printing;programs;Puerto Rican;Random Allocation;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research;Resources;Role;satisfaction;Self Efficacy;Smoke;Smoking;smoking abstinence;smoking cessation;Spanish;Spanish/English;standard of care;Structure;Surveys;synergism;Text Messaging;text messaging intervention;Tobacco;Tobacco use;treatment effect;United States;wearable device;Woman

PROJECT_TITLE: Actívatexto: Advancing smoking cessation and physical activity among Latinos

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on investigating a fundamental cause of racial health disparities in Black Americans, residential segregation. Further, it examines how segregation affects the universal aging process that underlies most chronic disease.

PI_NAMEs: FORRESTER, SARAH N (contact)

PROGRAM_OFFICER_NAME: POOL, LINDSAY REGINA

PROJECT_TERMS: Adult;Affect;Age;age acceleration;Aging;aging process;American;Black American;Black Populations;Black race;Blood Pressure;built environment;burden of illness;C-reactive protein;Cardiovascular Diseases;Chronic Disease;Civil Rights;clinical biomarkers;Clinical Markers;cohort;Color blindness;Coronary Artery Risk Development in Young Adults Study;Data;Development;Diabetes Mellitus;DNA Methylation;economic disparity;Education;Employment Opportunities;Equation;Equity;evidence base;Exposure to;Glucose;Goals;Government;Growth;Health;health disparity;health equity;Hormones;Hypertension;Inequity;innovation;Knowledge;Laws;Lead;Legal;Length;lens;Life Cycle Stages;Link;Longitudinal Studies;Measurement;Measures;Mediating;Mediator;middle age;Modeling;mortality;neighborhood disadvantage;Neighborhoods;novel;Onset of illness;Outcome;Participant;Pathway interactions;Physiological;Policies;policy recommendation;Population;Process;Public Health;Race;racial disparity;racial health disparity;racial population;Racial Segregation;reconstruction;Recording of previous events;recruit;Research;residential segregation;segregation;social;social determinants;social disparities;social health determinants;Societies;Socioeconomic Status;Stress;Stroke;structural determinants;Structural Racism;telomere;Testing;Time;United States;Work;young adult

PROJECT_TITLE: Residential Segregation and Physiological Dysregulation among Black CARDIA participants: A Longitudinal Study

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE: COVID-19 and influenza vaccination are essential to reducing racial/ethnic disparities in infectious disease morbidity and mortality. However, African American/Black and Latino populations have serious barriers to COVID-19 and influenza vaccination and, therefore, insufficient vaccination rates. The proposed study will use the multiphase optimization strategy framework to address the problem of low COVID- 19 and influenza vaccination rates for this population: We will test the effects of four candidate intervention components and then create a efficient multicomponent intervention comprised of the most cost-effective combination of components, which can then be rapidly scaled up in community and outpatient health care settings to boost COVID-19 and influenza vaccination rates annually.

PI_NAMEs: GWADZ, MARYA  (contact)

PROJECT_TERMS: Address;Adult;African American;Altruism;American;Appointment;Behavior Therapy;Black Populations;Black race;Cessation of life;Characteristics;Cognitive;Communicable Diseases;Communities;community engaged intervention;community partners;Complex;cost effective;cost effective intervention;cost effectiveness;COVID-19;COVID-19 disparity;COVID-19 vaccination;COVID-19 vaccine;Death Rate;design;disability;Disease;disparities in morbidity;Disparity;distrust;Dose;Engineering;ethnic disparity;ethnic health disparity;experience;Future;future pandemic;Health behavior;Health Benefit;health care settings;health disparity;Health Educators;health organization;Healthcare Systems;high risk;Hospitalization;hospitalization rates;Immunization Programs;improved;Individual;Influenza;Influenza vaccination;influenza virus vaccine;Institution;Intervention;intervention program;Interview;Knowledge;Latino;Latino Population;Long COVID;Mediator;Medical;Morbidity - disease rate;mortality;multi-component intervention;multiphase optimization strategy;New York;Nurses;optimism;Outcome;Outpatients;Participant;peer;Persons;Population;primary outcome;Prize;Public Health;Qualitative Research;racial disparity;racial health disparity;Randomized;Randomized, Controlled Trials;Reduce health disparities;Research;response;Risk;Risk Reduction;scale up;seasonal influenza;secondary outcome;shared decision making;social;social cognitive theory;sociodemographics;Spanish/English;Testing;text messaging intervention;theories;Touch sensation;Trust;Universities;Update;Vaccination;vaccine acceptance;vaccine hesitancy;vaccine trial;Vaccines

PROJECT_TITLE: Community - based behavioral intervention to increase COVID - 19 and influenza vaccination for African American/ Black and Latino persons: An optimization randomized controlled trial


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Pediatric

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE  Increasing evidence suggests that selective serotonin reuptake inhibitors (SSRIs) suppress height growth in young adolescents. In this application, we seek to determine the extent of SSRI-induced height growth suppression in mid-puberty, whether adult height would be ultimately reduced, and whether differences exist between the four most prescribed SSRIs.

PI_NAMEs: CALARGE, CHADI A. (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: 17 year old;19 year old;20 year old;Address;Adolescence;Adolescent;Adult;Adverse event;Affect;Age;age group;anti-depressive agents;Anxiety Disorders;Body mass index;bone age;boys;Bronchodilator Agents;Child;Childhood;Chronic;Citalopram;Clinical;clinical decision-making;clinical predictors;Clinical Trials;clinically significant;Cognitive;Data;Depressive disorder;Development;Dose;Drug Prescriptions;Enrollment;Epiphysial cartilage;Escitalopram;evidence base;Failure;Femur;Fluoxetine;follow-up;Functional disorder;Funding Opportunities;girls;Growth;Growth Factor;Height;hormonal signals;Hormone secretion;inhibitor therapy;Insulin;Investigation;Light;long-term sequelae;Major Depressive Disorder;male;Metabolic;Obesity;Participant;Pharmaceutical Preparations;pre-clinical;Predisposition;Prevalence;psychologic;psychostimulant;Psychotherapy;Puberty;Rattus;Reporting;Research;Risk Factors;Risk Reduction;Sampling;Selective Serotonin Reuptake Inhibitor;Serotonin;Sertraline;Serum;sex;side effect;Somatotropin;Staging;Time;Work;Writing;Youth

PROJECT_TITLE: Long-term Trajectory of SSRI-Induced Height Growth Suppression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: NARRATIVE RUNX1 is mutated in a familial platelet disorder that predisposes these patients to blood cancer (FPDMM). This work will define what genes RUNX1 regulates, and it will also determine how RUNX1 controls the transcription of these genes to promote normal blood development. Thus, this proposal will yield a comprehensive paradigm for the cause of RUNX1-FPDMM

PI_NAMEs: STENGEL, KRISTY  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acute;acute myeloid leukemia 1 protein;Alleles;Blood;Blood Platelets;Bone marrow failure;Cell Line;Cell Lineage;cell type;Cells;ChIP-seq;cofactor;Collaborations;Complement;Complex;conditional knockout;Development;dyserythropoietic anemia;Embryo;Engineering;Excision;Familial Platelet Disorder;FLI1 gene;GATA1 gene;Gene Expression;Gene Expression Profile;gene network;gene repression;Genes;Genetic;Genetic Transcription;Germ Lines;Germ-Line Mutation;Hematopoiesis;Hematopoietic;hematopoietic gene;Hematopoietic Neoplasms;Hour;Human;in vivo;insight;Knock-out;loss of function mutation;Lymphoid Cell;Malignant Neoplasms;Mediating;Modeling;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;Mutate;Mutation;Myeloid Cells;Myeloproliferative disease;Nature;novel;Overlapping Genes;Patients;Phenotype;Predisposition;Process;Production;programs;Proteins;Reagent;Regulation;Repression;Role;RUNX1 gene;small molecule;stem cell function;Technology;Testing;Thrombocytopenia;Time;Tissues;tool;transcription factor;Transcriptional Activation;Transcriptional Regulation;Work

PROJECT_TITLE: Mechanisms of RUNX1 transcriptional control in hematopoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Epilepsy;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Pediatric

ORG_DEPT: GENETICS

PHR: Project Narrative Sialidosis is a fatal and untreatable neurological disease that has no effective therapy. Patients suffer from seizures, uncontrollable movements of arms and legs, organ dysfunction and bone disease. Here we bring a gene therapy from mice to sheep with sialidosis to be ready for first in human clinical trials.

PI_NAMEs: GRAY-EDWARDS, HEATHER L (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Acids;Adolescent;Adult;Affect;Animal Model;Animals;Appearance;arm movement;Autopsy;base;behavior test;Biological Assay;Biological Markers;Blindness;Blood;bone;Bone Diseases;Brain;carboxypeptidase C;Cataract;Central Nervous System;Cessation of life;Cherry - dietary;Child;Childhood;Clinic;clinical translation;clinical trial readiness;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;combinatorial;Complementary DNA;CRISPR/Cas technology;Cytoplasm;Data;Deformity;Dependovirus;design;Developmental Delay Disorders;Diffuse;Disease;Dose;Dysostoses;effective therapy;experience;Experimental Designs;first-in-human;Flow Cytometry;Functional disorder;Funding;Future;gene therapy;Genes;Genetic Diseases;Grant;Hepatosplenomegaly;Histology;Human;human data;human model;Immune response;Immunohistochemistry;Immunologic Monitoring;infancy;Injections;Intravenous;Investigational New Drug Application;Knock-out;Knockout Mice;lead candidate;Leg;life span;Lipomucopolysaccharidoses;Liquid substance;loss of function mutation;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Maximum Tolerated Dose;middle age;Modeling;Molecular Chaperones;Monitor;mouse model;Mus;Mutation;Myoclonic Epilepsies;Myopia;Natural History;Neonatal;Nerve Degeneration;Nervous System Disorder;Neural Conduction;Neuraminidase;Neutralizing antibody assay;novel;Organ;palliative;Patients;Peptide Signal Sequences;perinatal period;Peripheral;Phenotype;Physical Restraint;pre-clinical;promoter;Proteins;Rare Diseases;Rattus;restoration;restraint;Rodent;Route;Safety;safety study;safety testing;sample collection;Satellite Viruses;Secondary to;Seizures;Sheep;sheep model;Sialic Acids;Site;Spinal Ganglia;Spottings;standard of care;T-Lymphocyte;Testing;Therapeutic;Tissues;Toxic effect;Toxicology;Transgenes;Translations;treatment group;treatment strategy;United States National Institutes of Health;Urine;vector;Vegetative States;virus testing;Wild Type Mouse;Work;young adult

PROJECT_TITLE: AAV Gene Therapy for Sialidosis: from Mice to IND

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke;Telehealth

ORG_CITY: ATLANTA

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Stroke is a leading cause of long-term disability and to date, research has placed little emphasis on how to integrate carepartners (family members) into the rehabilitation process without increasing negative carepartner outcomes. We have developed and implemented a novel, web- based carepartner partner-focused intervention (CARE-CITE) designed to foster problem- solving and skill building while facilitating carepartner engagement during upper extremity practice of daily activities in the home setting. By providing a family-focused approach to rehabilitation interventions, this project will help develop more effective treatments that improve both carepartner and stroke survivor outcomes after stroke.

PI_NAMEs: BLANTON, SARAH R. (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Accelerometer;Activities of Daily Living;Address;Adherence;Affect;attentional control;care burden;care systems;Caregiver Burden;Caring;Chronic;Clinical;comparative efficacy;Conflict (Psychology);constraint induced movement therapy;Control Groups;Creativeness;Data;Development;disability;E-learning;Educational process of instructing;effective therapy;efficacy testing;Empathy;Evaluation;exercise program;expectation;experience;Family;Family member;Fostering;functional improvement;functional independence;functional loss;Gait;Goals;health related quality of life;Home;Home visitation;Impairment;improved;innovation;integrated care;Intervention;Intervention Studies;Language;Learning;Life;Long term disability;Motivation;Motor Activity;motor recovery;Motor Skills;National Institute of Child Health and Human Development;novel;Online Systems;Outcome;Patient Outcomes Assessments;Performance;Persons;Play;post intervention;post stroke;Problem Solving;Process;prognostic indicator;programs;Protocols documentation;psychosocial outcome;Public Health;Quality of life;randomized, clinical trials;Recovery;recruit;Rehabilitation Centers;Rehabilitation therapy;Reporting;Research;Safety;satisfaction;skill acquisition;skills;social engagement;Social support;stressor;Stroke;stroke recovery;stroke rehabilitation;stroke survivor;supportive environment;Survivors;telerehabilitation;Testing;theories;Therapeutic Intervention;therapy design;therapy outcome;Training;Translating;United States National Institutes of Health;Upper Extremity;virtual;virtual delivery;Work

PROJECT_TITLE: Efficacy and Sustainability of a CarePartner-Integrated Telerehabilitation Program for Persons with Stroke

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Cancer;Childhood Leukemia;Hematology;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: Newark

ORG_DEPT: NEUROSURGERY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE In the United States, chemotherapy-induced cognitive impairments have emerged as a major adverse effect affecting approximately 35% of 500,000 childhood cancer survivors. The findings of this proposal are critical towards elucidating dysregulation of PARP1-dependent NAD+ metabolic signaling pathways mediating chemotherapy-induced neurocognitive decline in children with acute lymphoblastic leukemia. To this end, we will test if PARP1-dependent NAD+ metabolic pathways can be novel biomarkers and therapeutic targets to ameliorate chemotherapy-induced neurocognitive impairments.

PI_NAMEs: COLE, PETER D.;JANG, MI-HYEON  (contact)

PROGRAM_OFFICER_NAME: CLIFFORD, JOHN LEO

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute T Cell Leukemia;Address;Adolescent;Adult;Adverse effects;Affect;age related biomarkers;Antineoplastic Agents;anxiety-like behavior;Automobile Driving;Behavioral;Biological Markers;biomarker identification;Brain;Cancer Survivor;cancer therapy;cell type;Cerebrospinal Fluid;chemobrain;chemotherapy;Child;Childhood;Childhood Acute Lymphocytic Leukemia;childhood cancer survivor;Childhood Cancer Treatment;Cisplatin;Clinical;Clinical Trials;clinically relevant;Cognitive deficits;cognitive disability;cognitive function;cohort;Consumption;cyclooxygenase 2;Defect;Development;Diagnosis;DNA Damage;efficacy evaluation;efficacy testing;Enzymes;excitatory neuron;FDA approved;Genes;Hippocampus;Human;Impaired cognition;Impairment;improved;Induced Neurons;Inflammatory;inhibitor;insight;Intervention;Knockout Mice;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Medical;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methotrexate;Molecular;mouse model;Mus;Nerve Degeneration;nerve injury;Neurocognitive Deficit;Neurons;neuroprotection;neurotoxicity;new therapeutic target;NF-kappa B;Nicotinamide adenine dinucleotide;nicotinamide-beta-riboside;novel;novel marker;novel therapeutic intervention;Paclitaxel;patient derived xenograft model;Patients;pediatric patients;Permeability;Poly(ADP-ribose) Polymerases;potential biomarker;predictive marker;Predisposition;prevent;Quality of life;quality of life for cancer survivors;Reporting;sensor;Signal Pathway;Signal Transduction;Testing;Therapeutic;therapeutic development;tumor;tumor growth;United States;Work

PROJECT_TITLE: Identification of novel biomarkers and therapeutic strategies in chemobrain.

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE The overarching goal of this proposal is to better understand the neuronal and network abnormalities along the biological progression of Alzheimer’s disease (AD). Successful completion of our multimodal clinical investigation will more precisely determine the role of network dysfunction and hyperexcitability as candidate therapeutic targets to help prevent and slow AD and related dementias (ADRD).

PI_NAMEs: RANASINGHE, KAMALINI GAYATHREE (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Acceleration;Age;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-Protein;Animal Model;Basic Science;Biological;Biological Assay;Brain;Clinical;clinical investigation;Clinical Trials;Cognitive;Cognitive deficits;cognitive testing;cohort;Data;Dementia;Deposition;Disease;Disease Progression;Early Intervention;Education;Electrophysiology (science);entorhinal cortex;epileptiform;Equilibrium;Evaluation;excitatory neuron;executive function;follow-up;Goals;Human;imaging study;Impaired cognition;improved;in vivo;Individual;Inferior;inhibitory neuron;insight;Investigation;Knowledge;Language;Link;Lobule;Longitudinal Studies;Magnetic Resonance Imaging;Magnetoencephalography;Measures;Mediating;Mediation;Mediator;Memory;Metals;mild cognitive impairment;Modeling;molecular imaging;Multimodal Imaging;multimodal neuroimaging;multimodality;neocortical;Nerve Degeneration;network dysfunction;neural;neural circuit;Neurofibrillary Tangles;Neurologic Symptoms;Neuronal Dysfunction;Neurons;Neuropsychology;non-invasive imaging;novel;Parameter Estimation;Parietal;Participant;Pathogenesis;Pathologic;Pathology;Patients;Pattern;Periodicals;Positron-Emission Tomography;pre-clinical;Predisposition;prevent;Process;research clinical testing;Research Project Summaries;Resolution;Role;sex;Signal Transduction;source localization;spatiotemporal;tau aggregation;tau Proteins;Tauopathies;Techniques;Testing;therapeutic candidate;therapeutic target;uptake;Visuospatial;Work

PROJECT_TITLE: Electrophysiological and molecular imaging of early AD progression

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Cancer;Clinical Research;Kidney Disease;Organ Transplantation;Prevention;Transplantation

ORG_CITY: MINNEAPOLIS

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

ORG_STATE: MN

PHR: Project Narrative / Public Health Significance Kidney transplant is the best treatment for chronic kidney failure, but the immune-suppressing medications also increase the risk of getting and dying from cancer. Because of this, transplant providers may require that patients who have had cancer in the past be in remission for years before they are transplanted, but there is little evidence to guide these practices. In order to provide the best care for patients with chronic kidney failure, transplant providers need quality data on how the risks of cancer recurrence after transplant balance against the risk of dying while waiting for a kidney transplant.

PI_NAMEs: HART, ALLYSON  (contact)

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Address;Affect;Age;aging population;Breast;Cancer Patient;cancer recurrence;Cancer Remission;cancer risk;cancer transplantation;cancer type;Cessation of life;Characteristics;Chronic Kidney Failure;Clinical;clinical decision support;Colorectal;Communication;comorbidity;dashboard;Data;Data Analyses;Data Set;Database Management Systems;Databases;Dialysis patients;Dialysis procedure;Disease remission;End stage renal failure;Equilibrium;Expert Opinion;Face;Future;General Population;genetic linkage analysis;Goals;Hawaii;Immune;Immunosuppression;improved;Individual;individual patient;Information Systems;Investigation;Iowa;Kidney;Kidney Failure;Kidney Transplantation;Knowledge;Link;Lung;Lymphoma;Malignant Neoplasms;Melanoma;Mission;Modeling;mortality;mortality risk;multiple data sources;National Institute of Diabetes and Digestive and Kidney Diseases;neoplasm registry;New York;novel;Nurses;Oncology;online resource;Organ;Organ Transplantation;Outcome;Patient Care;Patients;Pharmaceutical Preparations;Physicians;Population;Positioning Attribute;post-transplant;Probability;Production;programs;Provider;Public Health;Recommendation;Recording of previous events;Registries;Renal Carcinoma;Research Personnel;Risk;Risk Estimate;Solid;Stage at Diagnosis;support tools;Testing;Texas;Time;tool;transplant centers;Transplant Recipients;transplant registry;Transplantation;trend;Uncertainty;United States;usability;user-friendly;virtual;Wait Time;Waiting Lists;web site

PROJECT_TITLE: A clinical decision support tool to understand the survival benefit of kidney transplantation in candidates with a history of cancer

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative Although breast cancer (BC) and cardiovascular disease (CVD) represent two of the most common causes of mortality among women, certain medications for these diseases, such as chemoprevention and statins, can lower a woman’s risk. Yet, low uptake of chemoprevention continues to perplex BC researchers, particularly given high-risk women’s expressed desire for risk-reduction options and the considerable resources expended to develop effective chemopreventive agents. By integrating CVD risk assessments into our existing decision aid, there is a potential to illuminate the previously unaddressed barriers to chemoprevention decision-making in the context of competing comorbidities like CVD and to educate women about ways to mitigate their risk for BC and CVD.

PI_NAMEs: CREW, KATHERINE D;KUKAFKA, RITA  (contact)

PROGRAM_OFFICER_NAME: DEAN, DAVID WORTH

PROJECT_TERMS: academic standard;Address;Adopted;Adoption;Affect;Age;Aromatase Inhibitors;Atypical hyperplasia;Belief;Benefits and Risks;Blood Vessels;Breast Cancer Risk Factor;Breast Diseases;breast lesion;Calibration;cancer chemoprevention;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular disorder therapy;Chemoprevention;Chemopreventive Agent;Chronic;Chronic Disease;Clinic;Clinical Trials;Cluster randomized trial;comorbidity;Conflict (Psychology);Consolidated Framework for Implementation Research;contextual factors;Decision Aid;Decision Making;design;Diabetes Mellitus;Disease;Dose;Dyslipidemias;Educational Materials;Effectiveness;effectiveness evaluation;Eligibility Determination;Equity;ethnic diversity;ethnic minority;Ethnic Origin;Evaluation;Event;experience;Exposure to;Focus Groups;genetic testing;Goals;health literacy;Health Personnel;Health system;Hereditary Breast Carcinoma;high risk;High Risk Woman;human centered design;Hydroxymethylglutaryl-CoA reductase;Hypertension;implementation facilitators;implementation intervention;improved;Incidence;Individual;informant;inhibitor;Intervention;Interview;lobular breast carcinoma in situ;Malignant Breast Neoplasm;Maps;mathematical ability;Methods;mortality;multi-ethnic;novel strategies;Obesity;Participant;Patient Education;Patients;Perception;Pharmaceutical Preparations;Placebos;prevent;Preventive measure;Preventive therapy;primary care provider;primary outcome;Primary Prevention;Process;prototype;Provider;Public Health;Qualitative Methods;Race;racial diversity;racial minority;Randomized;Randomized, Controlled Trials;Relative Risks;Research Personnel;Resources;Risk;Risk Assessment;Risk Factors;Risk Reduction;risk sharing;secondary outcome;Selective Estrogen Receptor Modulators;Subgroup;support tools;Surveys;Tamoxifen;Testing;tool;uptake;usability;Woman;Women's mortality

PROJECT_TITLE: Integrating Breast Cancer and Cardiovascular Disease Risk to Explore Decision-Making for Chemoprevention Among Racially/Ethnically Diverse Women at High Risk for Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_DEPT: MISCELLANEOUS

PHR: The proposed program will develop robust, efficient, and flexible dual-duration and multi-wavelength fiber sources of light enabling several orders of magnitude contrast enhancement for nonlinear and multimodal label-free, deep, and diffraction-limited imaging in living tissue. Building from advances in ultrashort pulse generation pioneered by the PIs, all of the critical pulse durations and wavelengths required for the major nonlinear imaging modalities can be achieved synchronously, for the first time, in a compact and accessible multimodal imaging platform. Successful completion of this program will have major impact for biomedical research and clinical applications by significantly improving performance and broadening access to this powerful new technology for deep-tissue, label-free, nonlinear optical imaging.

PI_NAMEs: RENNINGER, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Atherosclerosis;Biological Markers;Biomedical Research;clinical application;clinically relevant;contrast enhanced;contrast imaging;cost;design;Diagnosis;digital;Environment;experimental study;Fiber;Fiber Optics;flexibility;Fluorescence;Generations;Goals;Histologic;Image;imaging modality;imaging platform;imaging system;Imaging Techniques;improved;Label;Laboratories;Lasers;lens;Light;Malignant Neoplasms;Microscope;Modality;Molecular;multi-photon;Multimodal Imaging;multimodality;Mus;Nervous System Disorder;new technology;Noise;Non-linear Models;novel;optical imaging;Performance;Phase;Physiologic pulse;Process;programs;Pump;Research;Residual state;response;Risk;risk mitigation;Signal Transduction;Skin Tissue;Source;Speed;Structure;success;System;Targeted Research;Techniques;Technology;technology research and development;Theoretical model;Time;Tissues;Training;Translating;two-photon;Ytterbium

PROJECT_TITLE: Flexible dual-duration multi-wavelength fiber sources for nonlinear and multimodal imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-Y (82)]


ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Relevance to Public Health Statement  B cell malignancies are significant health issues both in the US and worldwide, constituting more than 50% of blood cancers, approximately 85% of lymphomas, and all myelomas. Despite recent treatment advancements that significantly improve patient survival, many B cell malignancies remain incurable. This new R01 project aims to elucidate novel paradigm-shifting mechanisms of B cell tumorigenesis, treatment resistance, and relapse driven by commensal bacteria-derived molecules, which can be exploited to develop new diagnostics and therapeutics to transform the management of B cell malignancies.

PI_NAMEs: XIE, PING  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Acceleration;Adoptive Transfer;Affect;anti-cancer research;Antibiotic Therapy;Antibodies;Antigen Receptors;Antigens;autocrine;B Cell Proliferation;B lymphoid malignancy;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Cell Neoplasm;B-Lymphocyte Subsets;B-Lymphocytes;Bacterial Antigens;BCL2 gene;Blood Circulation;Breeding;carcinogenesis;care systems;Cell Line;cell type;Cells;Cessation of life;Clone Cells;Colon Carcinoma;Colorectal Cancer;commensal bacteria;cytokine;Data;Development;Diagnostic;Digestion;Disease;Early Diagnosis;Early treatment;Epigenetic Process;Genetic;Genetic Predisposition to Disease;Health;Hematopoietic Neoplasms;Heterogeneity;Human;Human body;Immune;Immune Sera;improved;in vivo;Individual;insight;Investigation;Knowledge;Ligands;LoxP-flanked allele;lymphatic drainage;lymphoid organ;Lymphoma;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;migration;Modeling;mouse model;Multiple Myeloma;Mus;mutant;Neoplasm Metastasis;novel;novel diagnostics;novel therapeutics;Oncogenic;Pathogenesis;Pathway interactions;patient derived xenograft model;Patient Monitoring;Patient-Focused Outcomes;Patients;premalignant;Public Health;Receptor Signaling;Relapse;relapse prevention;Research;response;Signal Pathway;Signal Transduction;single-cell RNA sequencing;standard of care;stemness;Sterility;Stromal Cells;Structure;Surface;Systemic infection;targeted treatment;Testing;Therapeutic;therapy resistant;Toll-like receptors;treatment response;tumor growth;tumor microenvironment;tumorigenesis;Vaccination;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Novel mechanisms of B cell tumorigenesis and relapse

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Transcription factors (TFs) have been implicated in many diseases like cancer, but despite their high therapeutic potential the vast majority of TFs have resisted traditional drug discovery efforts. To address this challenge, we developed a new and generally approach to create synthetic transcriptional repressors (STRs), which can potently and specifically bind to target DNA sequences to thereby block cancer-causing TFs from regulating gene expression. We now propose to design and test more potent and specific STRs that directly block XBP1/HIF1alpha-DNA binding, profile their effects on oncogenic gene expression programs, and evaluate their therapeutic efficacy in cell and animal models of triple negative breast cancer.

PI_NAMEs: MOELLERING, RAYMOND E (contact);OAKES, SCOTT A.;ROSNER, MARSHA R

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Address;analog;analysis pipeline;Animal Model;Animals;ATAC-seq;Binding;Binding Proteins;Binding Sites;Biochemical;biological adaptation to stress;Biological Assay;blocking factor;Breast Cancer Cell;Cell Culture Techniques;Cell Death;cell growth;Cell Line;Cell model;Cell Survival;Cells;Chemoresistance;chemotherapy;ChIP-seq;Chromatin;Complex;Cytostatics;Cytotoxic agent;Data;design;Development;Disease;DNA Binding;DNA Sequence;DNA-Protein Interaction;drug discovery;Drug Targeting;efficacy testing;Engineering;Epigenetic Process;experimental study;Exposure to;Factor X;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;Goals;Growth;HIF1A gene;Human;Hyperactivity;Hypoxia;hypoxia inducible factor 1;Implant;improved;In Vitro;in vivo;in vivo Model;inhibitor;insight;Intravenous;Invaded;Laboratories;Lead;lead optimization;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Measures;meter;Molecular;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel therapeutics;Nutrient;Oncogenic;Organoids;Oxygen;Pathogenesis;patient prognosis;Patients;Permeability;pharmacodynamic biomarker;pharmacologic;Phenotype;Pre-Clinical Model;Preclinical Testing;Primary Neoplasm;Process;programs;Property;Protein Biosynthesis;protein metabolism;Proteins;Reporter;response;Response Elements;RNA Splicing;Series;Signal Transduction;Starvation;Stimulus;Stress;stressor;targeted treatment;Testing;Therapeutic;traditional therapy;transcription factor;Transcription Repressor;transcriptome sequencing;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor hypoxia;tumor microenvironment;tumor progression;Tumor Promotion;Up-Regulation;Work;Xenograft procedure

PROJECT_TITLE: Direct targeting of HIF1a-driven transcription in TNBC with engineered STRs

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE A major threat to national efforts to better integrate health care for dual eligible Medicare-Medicaid beneficiaries (‘duals’), a population with complex medical and social needs, has emerged in the form of non- integrated Medicare Advantage (MA) Dual-Eligible Special Needs Plans (D-SNP) “look alike” plans, which circumvent all state and federal regulations to coordinate health care for duals. Using a quasi-experimental study design and national Medicare-Medicaid administrative data, this study will evaluate the impact of a 2023 federal regulation—the “80% rule"—that eliminates “look-alike” plans on: 1) enrollment changes into integrated care plans (ICPs, which have the potential to improve quality, efficiency and outcomes for duals) and the key factors associated with ICP enrollment, 2) potentially avoidable or low-value health care use, and 3) quality of care and clinical outcomes among duals overall (plus a subset of high-risk duals with dementia, mental illness, frailty, multimorbidity, and from minoritized groups), and among duals who transitioned into ICPs vs. non-ICPs. Findings from this study will guide policymakers’ efforts to improve integrated care for duals—including consideration of further regulation to eliminate the full threat of look-alike plans—to better meet the needs of some of our country’s most medically complex and socially vulnerable people.

PI_NAMEs: FIGUEROA, JOSE FRANCISCO (contact)

PROJECT_TERMS: Address;Alzheimer's disease related dementia;Area;beneficiary;Black Populations;Black race;care coordination;Caring;Clinical;Communities;community-level factor;comparison group;Complex;Contracts;Control Groups;cost shifting;Country;Data;Dementia;deprivation;Disparity;Drops;dual eligible;Dual Enrollment;Effectiveness;Enrollment;Ensure;Equity;ethnic minority population;Ethnic Origin;experience;financial incentive;frailty;Goals;Growth;Health;health care quality;Healthcare;high risk;Home;improved;Incentives;insight;Institution;Insurance;Insurance Carriers;integrated care;Latino;Latino Population;Lead;Long-Term Care for Elderly;Managed Care;Managed Care Programs;marginalization;Marketing;Mediating;Medicaid services;Medical;Medicare;Medicare/Medicaid;Mental disorders;Minority Groups;mortality;multiple chronic conditions;Natural experiment;Outcome;Patients;Persons;Phase;Policies;Policy Maker;Population;Primary Care;programs;Quality of Care;Quasi-experiment;Race;racial minority population;rapid growth;Regulation;Reporting;Research;Research Design;severe mental illness;social;social vulnerability;Special needs plan;trend;United States Centers for Medicare and Medicaid Services;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: Integrated Care Plans and Health Care Quality, Outcomes, and Equity for Medicare-Medicaid Dual Eligible Beneficiaries with Multimorbidity, Frailty, or Dementia

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Emergency Care;Heart Disease;Machine Learning and Artificial Intelligence;Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Thousands of children have in-hospital cardiac arrests each year. Administration of epinephrine is recommended in all cardiac arrests, but its physiologic effects and therapeutic benefits vary between patients, suggesting that a personalized, physiology-directed epinephrine dosing strategy may be efficacious. Therefore, this multicenter study seeks to better delineate the physiologic effects of epinephrine during cardiopulmonary resuscitation and how that information can inform more targeted epinephrine dosing strategies to improve outcomes.

PI_NAMEs: MORGAN, RYAN WILLIAM (contact)

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Address;Adult;Advocate;Algorithms;Animals;Carbon Dioxide;Cardiopulmonary Resuscitation;Caring;Characteristics;Child;Childhood;Circulation;Classification;Clinical;clinical practice;Clinical Research;Collaborations;coronary perfusion;Data;Data Element;Data Set;design;Development;Diastolic blood pressure;Disease;Dose;Epinephrine;Future;Guidelines;Heart Arrest;hemodynamics;Hospitals;improved;improved outcome;individual patient;Infrastructure;Intervention Trial;Knowledge;Laboratories;Machine Learning;machine learning algorithm;machine learning model;Measurement;Measures;method development;Methods;Modeling;Monitor;Multicenter Studies;novel;Observational Study;Outcome;Patients;Peripheral Resistance;Pharmaceutical Preparations;Photoplethysmography;Physiologic Monitoring;Physiological;Physiology;predicting response;pressure;Process;prospective;Pulse Oximetry;Recommendation;Research Design;responders and non-responders;response;Resuscitation;Sample Size;Sampling;Site;System;Techniques;Therapeutic;Time;treatment response;United States;Work

PROJECT_TITLE: Physiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest (PEDICA)

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Despite significant advances in pediatric cancer treatment, childhood cancer remains the commonest cause of death from disease in children, due to resistance of the tumor cells to drug treatment. Our recent research has unveiled a new mechanism of cancer drug resistance driven by virus-like components of our genome known as “retrotransposons”. We've identified a way to block this resistance by safe drugs already used for viral diseases and discovered that the immune system can target cells with activated retrotransposons. Our program aims to explore these findings further, potentially offering new hope to children with currently untreatable cancers.

PI_NAMEs: GUDKOV, ANDREI V (contact);HABER, MICHELLE

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Adult;anti-PD-1;Anti-viral Agents;Antibodies;Antigens;Atlases;Basic Science;Biological Markers;Cancer Diagnostics;cancer drug resistance;cancer type;Cause of Death;Cell Line;Cells;Central Nervous System;Characteristics;Child;childhood cancer mortality;Childhood Cancer Treatment;Childhood Solid Neoplasm;Clinical;Clinical Data;clinical material;clinically relevant;Collaborations;Data;Dedications;Dependence;derepression;Diagnostic;Disease;DNA;DNA Sequence Analysis;Drug resistance;drug resistance development;efficacy evaluation;Epigenetic Process;epigenomics;Face;Fostering;Future;Genome;Genomics;Goals;high risk;Human;Human Genome;Immune response;Immune system;Immunity;Immunotherapeutic agent;Immunotherapy;improved;in vivo Model;Inflammation;inhibitor;insight;International;Intervention;Investigation;Knowledge;Link;liquid biopsy;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Modeling;Molecular;Monitor;Mus;MYCN gene;neoplastic cell;neural;Neuroblastoma;neuroblastoma cell;Normal Cell;novel;Nucleosides;Outcome;Pathway interactions;Patients;Peripheral Nervous System;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;pre-clinical;Pre-Clinical Model;Process;programs;prospective;Proteins;Pseudogenes;rational design;Recurrence;Recurrent disease;Refractory;Refractory Disease;Regulation;Research;Resistance;Retrotransposition;Retrotransposon;Reverse Transcriptase Inhibitors;Role;sample collection;Sampling;sensor;Solid Neoplasm;Stimulator of Interferon Genes;Study models;Survival Rate;Sympathetic Nervous System;T-Lymphocyte;Testing;Therapeutic;therapy resistant;TP53 gene;trait;transcriptome;Translational Research;Treatment outcome;treatment response;tumor;Tumor Antigens;tumor progression;Tumorigenicity;Up-Regulation;Vaccination;Virus;Virus Diseases;Work

PROJECT_TITLE: Targeting retrotransposons for improved treatment of refractory childhood cancer


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Regenerative Medicine

PHR: PROJECT NARRATIVE Many diseases are treatable with gene therapy, but it is difficult to target specific organs and large doses of vector are used to overcome this off-target loss. In this multi-PI project, we will develop a novel platform to enable cardiac gene therapy by encapsulating viral vectors in hydrogel delivered to the epicardium. These studies will test the ability of this strategy to minimize effective dose, overcome immune neutralization, and repair cardiac damage, validating it for clinical use.

PI_NAMEs: DOERING, CHRISTOPHER BRADLEY;GARCIA, ANDRES J;LEVIT, REBECCA DIANE (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Accounting;adeno-associated viral vector;Anatomy;Animal Model;Anti-Arrhythmia Agents;Anti-Inflammatory Agents;Biological;biomaterial compatibility;Biomedical Engineering;Blood;Blood Circulation;Blood flow;Blood Vessels;Ca(2+)-Transporting ATPase;Candidate Disease Gene;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;Cardiovascular Diseases;cell type;Cells;Cellular biology;cellular transduction;Central Nervous System;Cessation of life;Clinical;Clinical Trials;Coronary;coronary vasculature;cost;Data;delivery vehicle;Detection;Development;Devices;Disease;Dose;Encapsulated;Endoplasmic Reticulum;Engineering;Epicardium;ethylene glycol;Fluoroscopy;Follistatin;Formulation;Gel;Gene Delivery;Gene Expression;Gene Targeting;gene therapy;gene therapy clinical trial;Gene therapy trial;Gene Transduction Agent;Gene Transfer;Genes;Heart;heart damage;Heart Diseases;human disease;Hydrogels;Hydrolysis;Immune;Immune response;immunogenicity;Immunologics;In Vitro;in vivo;Inflammation;Infusion procedures;Injections;innovation;Intravenous;ischemic cardiomyopathy;Kinetics;Liver;Lung;Lung Diseases;Malignant Neoplasms;manufacture;Mediating;Methods;minimally invasive;Muscle;Muscle Cells;Natural regeneration;Needles;Neuro-Ocular System;neutralizing antibody;novel;Organ;Pathway interactions;Patients;Performance;Pericardial body location;pericardial sac;Physicians;Population;Procedures;Proteins;prototype;Rare Diseases;Reporting;Research;residence;Safety;Sarcoplasm;Scientist;Signal Transduction;Stream;System;targeted therapy trials;Technology;Testing;Therapeutic;therapeutic gene;Time;transduction efficiency;Transduction Gene;translational barrier;Translations;treatment strategy;United States;United States Food and Drug Administration;Vascularization;vector;Viral;Viral Vector;Virus

PROJECT_TITLE: Hydrogel Targeting of Organ Specific Gene Therapy

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Congenital Structural Anomalies;Digestive Diseases;Genetics;Liver Disease;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE A paucity in our understanding of the functional consequence of variation in the human genome is a major roadblock in the diagnosis and study of genetic disease. We will develop Multiplexed Assays of Variant Effects, MAVEs, to characterize the functional consequence of thousands of variants simultaneously in the disease genes JAGGED1 (JAG1) and NOTCH2, mutations in which cause Alagille syndrome, an autosomal dominant cause of pediatric liver, cardiac, vertebral, ocular, and renal disease. Scalable functional characterization using MAVEs will revolutionize the speed with which we are able to understand genomic findings, and we propose additional, complementary approaches to test assay through-put and employ high fidelity cell models to comprehensively interrogate the strength of functional assays for variant reclassification.

PI_NAMEs: GILBERT, MELISSA ANN (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Address;Affect;Alagille Syndrome;Alleles;Archives;autosome;Benign;Binding;Biochemical;Bioinformatics;Biological Assay;Biological Models;Biology;Biometry;Cardiac;Cell Line;Cell model;cell type;Cells;Childhood;Cholestasis;Classification;Clinical;ClinVar;Collaborations;Communities;Complement;Confusion;Data;Data Set;Defect;Deposition;design;Development;Diagnosis;Diagnostic;diagnostic value;Disease;Disparity;DNA;Environment;Eye diseases;Face;Frequencies;Gene Deletion;Genes;Genetic Diseases;Genetic Predisposition to Disease;Genetic study;genetic variant;genomic variation;Genomics;Goals;Hepatic;Hepatocyte;Heterodimerization;Human Genome;improved;Incidence;induced pluripotent stem cell;innovation;insight;interest;Kidney;Kidney Diseases;Libraries;Ligands;Liver;loss of function;Measures;Medical;member;Membrane;Minority;Modeling;multiplex assay;Mutation;notch protein;Nucleotides;Organoids;Pathogenicity;Patients;Population Database;prevent;Property;protein folding;protein function;protein misfolding;Protein Truncation;Proteins;Provider;receptor;receptor binding;Recording of previous events;Reporting;Reproducibility;Research;Resolution;Role;Sampling;Series;Signal Transduction;Sorting;Speed;spine bone structure;stem cell biology;stem cell model;structural biology;Structural Models;Structural Protein;System;Technology;Testing;tool;tool development;Uncertainty;Variant;variant of unknown significance;Work

PROJECT_TITLE: Impact and Utilization of Scalable Functional Assays in Alagille Syndrome

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Nutrition;Precision Medicine;Prevention

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Project Narrative The current Dietary Reference Intakes (DRIs) for iron are based on a relatively small number of studies from homogenous populations outside the US. The proposed study will determine dietary iron requirements in a large, representative sample of US adults. These data will serve as a crucial resource for informing the necessary updates to the current DRIs, ensuring they accurately reflect the specific needs of the increasingly diverse US population.

PI_NAMEs: HENNIGAR, STEPHEN R. (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Adult;Affect;Age;All of Us Research Program;Back;Biological Availability;burden of illness;Chronic Disease;Clinical;Consumption;Data;Data Set;Databases;Diabetes Mellitus;Diet;dietary;Dietary Iron;Dietary Practices;diverse data;Enrollment;Ensure;Ethnic Origin;European;Feces;Food;Food Patterns;Future;Health;Heart failure;Human;Infrastructure;Intake;Iron;iron absorption;iron deficiency;Iron Overload;Isotope Labeling;Isotopes;Liver diseases;men;Modeling;Myocardial dysfunction;Parents;Participant;Patient Recruitments;Peer Review;Physiological;Population;Population Heterogeneity;Precision Health;precision nutrition;prediction algorithm;prevent;Process;Protocols documentation;Public Health;Race;Randomized;Recommendation;recruit;Resources;response;Risk;risk mitigation;Sampling;sex;Site;Sum;Time;Update;Urine

PROJECT_TITLE: Dietary iron requirements in a diverse group of US adults

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health

PHR: PROJECT NARRATIVE Precision Medicine has now been firmly incorporated into the routine standard-of-care in many medical specialties, in stark contrast with Psychiatry where quantitative predictors that guide clinical decision-making remain extremely limited. Our proposed studies aim to advance the goals of Precision Psychiatry by using artificial intelligence to build clinical outcome predictors of psychosis through integration of electronic health records, dimensional phenotyping, and genetic information, in addition to exploring the psychosocial impact on patients and clinicians. Our long-term goal is to advance the tools available for personalized approaches to diagnosis, treatment, and prognosis in mental health.

PI_NAMEs: RZHETSKY, ANDREY  (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Address;Antipsychotic Agents;Artificial Intelligence;Attitude;biobank;cardiometabolism;Classification;CLIA certified;Clinical;clinical decision-making;clinical implementation;clinical practice;clinical predictive model;clinical predictors;clinical subtypes;Code;Cognition;cohort;comorbidity;Computer Analysis;Consensus;Consent;Copy Number Polymorphism;Data;Data Analytics;Data Collection;Database Management Systems;Databases;Diabetes Mellitus;diabetes risk;Diagnosis;Diagnostic;Dimensions;Disease;DNA;Electronic Health Record;emotional reaction;Ethics;experience;Future;Genetic;genetic analysis;Genetic Counseling;genetic information;genome sequencing;genomic data;Goals;Impairment;improved;Individual;individual patient;individualized medicine;Institutionalization;Insurance;Interview;Knowledge;Life;long term hospitalization;Machine Learning;Medicaid;Medical;medical specialties;Medicine;meetings;Mental Health;Methods;model building;Modeling;Monitor;mortality;multidisciplinary;Nature;New York;novel;Outcome;outcome prediction;Pathogenicity;Patient Recruitments;patient subsets;Patients;Perception;personalized approach;Persons;Pharmacological Treatment;Phenotype;phenotypic data;Population;Population Database;precision medicine;predict clinical outcome;predictive modeling;preventive intervention;Prognosis;prognostic;prospective;Psychiatry;Psychoses;psychosocial;Public Health;rare variant;Recovery;recruit;Refractory;Research;Resistance;Resource Allocation;Risk;Sampling;Schizophrenia;Services;severe mental illness;Severity of illness;side effect;Site;social health determinants;standard of care;Study models;Surveys;System;tool;treatment optimization;treatment planning;treatment response;Untranslated RNA;Validation;Variant;whole genome

PROJECT_TITLE: 5/5 Clinical Outcome Prediction of Psychosis from Electronic Health Records (COPPER)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-E (60)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BLACKSBURG

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed study will examine the contribution of developing neural markers—valuation and control—to substance use throughout adolescence and young adulthood (13-27 years) by following a well-characterized longitudinal sample recruited from understudied and underserved communities that have high rates of substance use and addiction. Thus, the neurobehavioral and psychosocial predictors of health risk behaviors in this cohort may provide important insights about health risk behaviors in this community and other high-risk populations. By clarifying (1) long-term effects between valuation and control decision-making systems and health risk behaviors throughout adolescence and young adulthood and (2) roles of psychosocial risk and resilience factors that influence these mechanisms, the proposed study will yield critical information for identifying youth with high neurobiological vulnerability for developing substance use disorders. The findings will further inform ways of designing optimally-timed, targeted prevention efforts to ameliorate developmental pathways of youth who are at risk for substance misuse and addiction.

PI_NAMEs: CASAS, BROOKS ;KIM-SPOON, JUNGMEEN  (contact)

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Adverse event;Behavioral;Brain;brain control;brain health;Brain imaging;Buffers;Childhood;cognitive control;cohort;Communities;Computer Models;Data;Decision Making;deprivation;design;Development;Developmental Process;early life adversity;Economics;experience;follow-up;Goals;Health;high risk population;Impaired cognition;Individual Differences;informant;insight;Intervention;Knowledge;Life Cycle Stages;Link;Literature;Long-Term Effects;longitudinal analysis;longitudinal, prospective study;Measurement;Measures;Mediating;Modeling;neglect;neural;neurobehavioral;Neurobiology;Neurocognitive;neuroimaging;neuromechanism;Neurosciences;novel strategies;Pathway interactions;Pattern;Performance;Persons;Populations at Risk;Poverty;prevent;Prevention;Process;prospective;psychosocial;Psychosocial Stress;recruit;Reporting;resilience factor;reward processing;Rewards;Risk;Risk Behaviors;Risk Factors;Risk Taking;Role;Sampling;social;social deprivation;social integration;Stress;Substance Addiction;substance misuse;substance use;Substance Use Disorder;Surveys;System;theories;Treatment/Psychosocial Effects;underserved community;Work;young adult;Youth

PROJECT_TITLE: Neurobehavioral and Psychosocial Predictors of Health Risk Behaviors in Adolescence and Young Adulthood

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Aging;Sarcopenia

ORG_CITY: GALVESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Project Narrative A progressive reduction in skeletal muscle mass and strength occurs during aging, a phenomenon known as “sarcopenia”. The prevalence of sarcopenia is expected to significantly increase due to the increasing proportion of elderly individuals in the populations of developed nations. The long-term goals of our research are to decipher how chemical modifications that occur during aging impact the function of myosin and associated chaperones which are vital for proper muscle function.

PI_NAMEs: BENIAN, GUY MARTIN;OBERHAUSER, ANDRES F. (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Adult;Affect;Affinity;Age;age effect;age related;age related chronic disease;Age Years;aged;Aging;aging related;Animal Model;Animals;Binding;Biochemical;Biological Assay;Biology;Biophysics;Caenorhabditis elegans;Cells;Cessation of life;chemical association;Chemicals;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Data;Developed Countries;Disease;Drug Design;Elderly;Enzymes;Genes;Goals;Head;Heat-Shock Proteins 90;Human;human old age (65+);In Vitro;in vivo;Individual;Induced Mutation;insight;Longevity;Maintenance;Maps;Measures;member;mimetics;Modification;Molecular;Molecular Chaperones;Motor;Motor Activity;multidisciplinary;Mus;Muscle;muscle aging;Muscle Development;Muscle Fibers;muscle form;Muscle function;Muscle Proteins;muscle strength;Muscular Atrophy;muscular structure;mutant;Mutate;Mutation;Myoblasts;Myofibrils;Myosin ATPase;Nematoda;novel;novel therapeutic intervention;Phenotype;Phosphorylation;Phosphorylation Site;Phosphoserine;Physical Performance;physically handicapped;Physiologic pulse;Population;Post-Translational Protein Processing;Prevalence;prevent;Process;Protein Family;Protein Kinase;Proteins;Quality of life;Recombinants;Research;Research Personnel;Sarcomeres;sarcopenia;Serine;Serine/Threonine Phosphorylation;Severities;Site;Skeletal Muscle;skeletal muscle wasting;Structure;Study models;success;System;Techniques;Testing;Thick Filament;Time;tool;Western Blotting

PROJECT_TITLE: The function of post-translational modifications of myosin and its chaperone UNC-45 that occur with adult aging

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]