ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Unhealthy alcohol use is common among Veterans and a significant risk factor for numerous negative health consequences, including chronic disease, injury, mortality, and suicide. It is also linked to increased financial and societal costs (e.g., higher healthcare utilization, criminal justice expenses). Due to these burdens, effective, evidence-based care for Veterans with unhealthy alcohol use was implemented in VA primary care settings. However, significant gaps in this care have been identified, indicating that a substantial proportion of Veterans in need of help are not receiving it. Improving the implementation of alcohol-related care in primary care settings has the potential to increase access to both preventive care (e.g., brief counseling interventions) and treatment (e.g., medications for alcohol use disorder), thereby significantly decreasing the harmful health and societal consequences associated with drinking.

PI_NAMEs: BACHRACH, RACHEL LAUREN (contact)

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Adoption;Adult;adverse outcome;Alcohol consumption;alcohol misuse;alcohol screening;alcohol use disorder;Alcohols;Area;care delivery;career;Caring;Centers of Research Excellence;Cessation of life;Chronic Disease;Clinic;Clinical;Clinical Psychology;Consolidated Framework for Implementation Research;Counseling;Criminal Justice;Data;disability;Doctor of Philosophy;drinking;Effectiveness;effectiveness outcome;effectiveness/implementation trial;Ensure;Evaluation;evidence base;Evidence based treatment;experience;Fellowship;Financial cost;financial incentive;Goals;Guidelines;Health;health care service utilization;Health equity research;Health Services;Health Services Accessibility;high risk;implementation evaluation;implementation intervention;implementation outcomes;implementation process;implementation science;implementation strategy;Improve Access;improved;Incentives;Individual;Injury;innovation;Intervention;intervention refinement;Interview;Investments;Knowledge;Leadership;Link;Measures;Medical;Medical Care Costs;medical specialties;meetings;Mental Health;Mentorship;Methodology;Methods;mortality;Opioid;Outcome;patient screening;Patients;Performance;Persons;Pharmaceutical Preparations;Pharmacotherapy;pilot test;Population;population based;Positioning Attribute;Postdoctoral Fellow;Prevention;Preventive care;Primary Care;primary care clinic;primary care provider;primary care setting;process improvement;Provider;Psychologist;Public Health;Qualitative Evaluations;Qualitative Methods;Quality of Care;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Reporting;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;Sampling;Scientist;screening;Services;societal costs;suicidal;suicidal risk;Suicide;Suicide prevention;Techniques;Testing;theories;therapy design;therapy development;Time;tool;Training;United States Preventative Services Task Force;Veterans;Work

PROJECT_TITLE: Implementation Intervention to Improve Care for Unhealthy Alcohol Use

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ADMINISTERING_IC: NR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Urologic Diseases

ORG_CITY: AUSTIN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative This project will develop a radio-frequency-based monitor that uniquely provides proactive alerts of bladder fullness as a support technology for toilet training for children and young adults with ASD/IDD. The monitor will be discreet and wearable, and designed to meet the needs and constraints of this diverse population. This proactive sensing approach will assist in the transition to independence for these individuals suffering from urinary incontinence, and help them achieve a higher quality of life and greater participation in educational and community settings.

PI_NAMEs: ESTEP, LAURA  (contact);PORTER, EMILY

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Accidents;Adult;aged;autistic children;Behavior;behavioral study;Bladder;care providers;Caregivers;Child;Clinical;community setting;Computer Simulation;design;Devices;Education;Electrical Engineering;Electromagnetics;Esthesia;flexibility;Focus Groups;Hygiene;Incontinence;Individual;individuals with autism spectrum disorder;Intellectual functioning disability;interdisciplinary approach;Learning;Measurement;Monitor;Parents;peer;pilot test;Population;Population Heterogeneity;psychologic;Quality of life;Questionnaires;radio frequency;response;Risk;sensor;social;Social isolation;Special Education;success;support tools;Surveys;Technology;Testing;Time;Toilet Training;tool;Urinary Incontinence;user centered design;Validation;wearable device;wireless;Work;young adult with autism spectrum disorder

PROJECT_TITLE: Continuity of User-Centered Design of a Proactive RF-Based Wearable Bladder Monitor for Toilet Training of Children with ASD/IDD


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE The Integrated Networks of Scholars in Global Health Research Training (INSIGHT) consortium formed between the University of Alabama at Birmingham, the Baylor College of Medicine, the University of Maryland Baltimore, and the University of Pittsburgh supports training for the next generation of global health scholars from the US and low- and middle-income countries (LMICs) through mentored research experiences at 24 established partner LMIC institutions across 19 countries in Africa, Asia, and Latin America and the Caribbean. Strong emphases are on a broad range of global health research areas, including combatting the global HIV epidemic and associated co-morbidities, emerging and re-emerging infectious diseases, non-communicable diseases, and mental health.

PI_NAMEs: CHARURAT, MANHATTAN E (contact);MANDALAKAS, ANNA M;NIMGAONKAR, VISHWAJIT LAXMIKANT;TURAN, JANET M.

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: Africa South of the Sahara;Applications Grants;Asia;Behavioral;career;Caribbean region;Clinical;cohort;Collaborations;Disease;Emerging Communicable Diseases;Ensure;Environment;Epidemic;equity, diversity, and inclusion;Faculty;Foundations;Generations;global health;HIV;innovation;Institution;interdisciplinary collaboration;Laboratories;Latin America;Link;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Minority-Serving Institution;Monitor;multidisciplinary;Outcome;outreach;Postdoctoral Fellow;pre-doctoral;Process;Program Evaluation;programs;Publishing;Research;Research Personnel;Research Training;Role;Schools;Science;Shapes;Strategic Planning;student participation;Training;Training Programs;Underrepresented Minority;Underrepresented Populations;Universities;Vision;Woman;Work


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Mental Health;Neurosciences;Pediatric

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Regulating stress is critical to healthy mental and physical development. Over the peripubertal period, there appears to be a waning in the effectiveness of social partners to buffer activation of stress-responsive physiological systems. The proposed research will determine the neural mechanisms of this effect as well as its pervasiveness, and will potentially improve interventions that support resilience to mental health problems in early adolescence.

PI_NAMEs: GUNNAR, MEGAN R (contact);THOMAS, KATHLEEN M

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 14 year old;Address;Administrative Supplement;Adolescent;Affective;Attention;Buffers;Child;COVID-19;Data Collection;Development;early adolescence;Effectiveness;Event;experimental study;Failure;Friends;Hydrocortisone;hypothalamic-pituitary-adrenal axis;imaging study;improved;indexing;Intervention;Knowledge;Measures;Mental Health;neural;neuromechanism;online version;pandemic disease;Parents;Participant;Pathology;Patient Self-Report;peripubertal period;Physiological;Psyche structure;Puberty;puberty transition;repaired;Research;resilience;Role;social;social stress;Staging;Stimulus;Stress;stress management;stress reactivity;Stressful Event;stressor;System;Teenagers;Time;Work

PROJECT_TITLE: Social Buffering Over the Pubertal Transition: COVID-19 Repair Supplement


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Ovarian Cancer;Rare Diseases;Uterine Cancer;Women's Health Research

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative Building from the methods and findings in the parent project, this supplement will identify the molecular mechanisms through which dysregulation of GATA2 and Piezo1 lead to invasion, metastasis, and poor patient outcome in uterine serous carcinoma. The long-term goal of these studies is to utilize GATA2 and/or Piezo1 immunohistochemistry as biomarkers to predict which patients with uterine serous carcinoma are at high risk of cancer recurrence and would benefit from adjuvant chemoradiation therapy while sparing patients with low risk of cancer recurrence from unnecessary adjuvant chemoradiation.

PI_NAMEs: KREEGER, PAMELA K (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Adjuvant;Adjuvant Chemotherapy;Adjuvant Therapy;Administrative Supplement;advanced disease;Agonist;Animal Model;antagonist;Behavior;Binding;Binding Sites;Biological Markers;Biological Models;cancer diagnosis;cancer recurrence;cancer risk;Carcinoma;Cell Line;Cessation of life;chemoradiation;chemotherapy;ChIP-seq;Clinical;Clinical Research;Clinical Trials;cohort;Collagen;Complement;CRISPR/Cas technology;Data Set;Deposition;design;Development;Diagnosis;Disease;Elderly woman;Endometrium;Enhancers;Event;Excision;Extracellular Matrix;Foundations;Future;GATA2 transcription factor;Gelatin;gene network;Genes;Genetic Enhancer Element;genome-wide;Goals;high risk;High-Risk Cancer;Histologic;Histology;Immunohistochemistry;improved;In Vitro;in vitro Model;in vivo Model;Incidence;Individual;insight;Institution;interest;Introns;Invaded;Ion Channel;Lead;Localized Disease;lymphatic Invasion;malignant ascites;Malignant Epithelial Cell;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Methacrylates;Methods;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;Mus;Neoplasm Metastasis;neoplastic cell;novel;Operative Surgical Procedures;Outcome;Ovarian Serous Adenocarcinoma;overexpression;parent project;Pathogenesis;Patient-Focused Outcomes;Patients;Piezo 1 ion channel;Play;Progesterone Receptors;prospective;Proteins;Radiation therapy;receptor expression;Recurrence;Recurrent disease;Repression;Research Personnel;response;Risk;Role;Sampling;Serous;small hairpin RNA;small molecule;spheroids;Stretching;survival prediction;System;Testing;Tissue Microarray;transcription factor;transcriptome sequencing;tumor;Tumor Burden;Up-Regulation;Uterine Cancer;Uterine Diseases;Uterus;Woman;Zinc Fingers

PROJECT_TITLE: The role of multi-cellular aggregates vs. individual tumor cells in metastasis of high-grade serous ovarian cancer


ADMINISTERING_IC: AI

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PI_NAMEs: KROGAN, NEVAN J (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Administrative Supplement;AIDS prevention;Biological;Biological Sciences;Budgets;Collaborations;Communication;Communities;Complex;Dedications;Development;Educational workshop;Electronic Mail;Ensure;Environment;Equipment;Equity;equity, diversity, and inclusion;Evaluation;Event;experience;Feedback;forging;Fostering;Future;Goals;Grant;HIV;HIV/AIDS;Human Resources;Infrastructure;insight;Institution;interest;International;Internships;Knowledge;Lead;Leadership;lectures;meetings;member;Mission;Monitor;National Institute of Allergy and Infectious Disease;new technology;next generation;outreach;podcast;programs;Reporting;Research;Research Personnel;Research Project Grants;Schedule;Scientist;Series;Sister;Site;structural biology;symposium;Systems Biology;therapeutic target;Underrepresented Minority;underrepresented minority student;underserved community;United States National Institutes of Health;web site

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emergency Care;Health Services;Hematology;Infectious Diseases;Kidney Disease;Patient Safety;Pediatric;Sepsis

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Septic shock is acute cardiovascular failure due to an infection that affects tens of thousands of children each year. Although crystalloid fluid resuscitation is the cornerstone of initial resuscitation, there is no definitive evidence for the most effective and safest type of crystalloid fluid in children. The objective of this large, pragmatic, randomized study is to test the comparative effectiveness of the two most common types of crystalloid to improve clinical outcomes in children treated for septic shock.

PI_NAMEs: BALAMUTH, FRANCES B (contact);WEISS, SCOTT L

PROGRAM_OFFICER_NAME: TAMBURRO, ROBERT F

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adult;Affect;Antibiotics;Applied Research;Australia;Biological;Bolus Infusion;Canada;Cardiovascular system;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Child;Childhood;Clinical;clinical practice;Collaborations;comparative effectiveness;comparative effectiveness trial;Critical Illness;crystalloid;Data;Dialysis procedure;Eligibility Determination;Emergency Care;Emergency research;Enrollment;Ethics;Event;Failure;Fluid Balance;Functional disorder;Hospitalization;Hospitals;Hour;Immune response;improved;Individual;Infection;Informed Consent;Kidney;kidney dysfunction;Knowledge;Length of Stay;Life;Liquid substance;Maintenance;Medical emergency;mortality;Multiple Organ Failure;New Zealand;Normal saline;open label;Organ;Outcome;patient oriented;Patients;pediatric emergency;Physiological;pragmatic trial;preference;preservation;primary outcome;prospective;Randomized;relative effectiveness;Renal Blood Flow;Resuscitation;Safety;Saline;secondary outcome;Sepsis;Septic Shock;Site;Specific qualifier value;Testing;treatment optimization;World Health Organization

PROJECT_TITLE: PROMPT BOLUS admin supplement

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Pediatric;Prevention

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Early childhood caries (ECC) remains the most common chronic childhood disease worldwide and causes a major impact on children, families, and healthcare systems, especially in low- and middle-income countries and underserved populations. Candida is frequently detected in the oral cavity of toddlers with severe ECC (S-ECC) and its presence is implicated with an elevated risk for S-ECC, but its role on the etiopathogenesis of the disease remains unclear. This study aims at elucidating whether early Candida infection in children during the first year of life is associated with S-ECC onset and severity in a longitudinal study.

PI_NAMEs: LIU, YUAN  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Address;Affect;Age;Age Months;Ambulatory Care;American;Applications Grants;Area;Bioinformatics;Biology;Biomedical Engineering;Biometry;Candida;Candida albicans;career;cariogenic bacteria;Child;Childhood;Chronic;Clinical;Clinical Markers;Clinical Research;cohort;Collaborations;Communicable Diseases;Communication;Computer Analysis;Databases;deciduous tooth;demineralization;dental biofilm;Dental caries;Dental Enamel;Dental Plaque;Dentition;design;Detection;Development;Diet Habits;Disease;dysbiosis;early childhood;Early Intervention;Economics;Electronic Health Record;Epidemiology;experience;Experimental Models;Exposure to;Family;follow-up;Foundations;fungus;Future;Goals;Grant;Hardness;Health;Healthcare Systems;Human;Image;improved;infancy;Infant;Infection;K-Series Research Career Programs;Knowledge;Left;Life;Link;Longitudinal Studies;longitudinal, prospective study;low and middle-income countries;Mentored Patient-Oriented Research Career Development Award;Mentors;Metabolic Pathway;metagenomic sequencing;Methods;microbial;Microbial Biofilms;microbial community;microbial composition;microbiome;microbiota;Microradiography;novel;Odontogenesis;Oral;Oral candidiasis;Oral cavity;oropharyngeal thrush;Pain;Pathogenesis;Pediatric Hospitals;Pennsylvania;Personal Satisfaction;Philadelphia;Play;prevent;Preventive;Preventive therapy;Process;programs;Property;Public Health;Recording of previous events;Research;Resources;Retrospective Studies;Risk;Risk Factors;Risk Marker;Role;Sampling;Scientist;Severities;sex;Shotguns;skills;social;spatiotemporal;Structure;sugar;Surface;Systemic infection;Techniques;Testing;Therapeutic;Toddler;Tooth structure;tooth surface;Training;Translational Research;Underserved Population;Universities;Virulence;Virulent;Visit;Writing

PROJECT_TITLE: Association between early Candida infection (oral thrush) and severe early childhood caries

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative The overall goal of this project is to develop PanKbase, a centralized and comprehensive resource of the human pancreas for the diabetes research community, with a focus on type 1 diabetes (T1D) pathogenesis. If successful, results from this project will provide new insights into T1D pathogenesis and enable the development of new therapies and biomarkers. The project will also foster cross-disciplinary collaborations and promote innovation, with the ultimate aim of improving the lives of people with T1D.

PI_NAMEs: LIU, JIE ;PARKER, STEPHEN CJ (contact)

PROGRAM_OFFICER_NAME: XIA, ASHLEY

PROJECT_TERMS: Biological Markers;Collaborations;Communities;Community Participation;Data Science;Databases;design;Development;Diabetes Mellitus;diabetes pathogenesis;Fostering;Foundations;Goals;Human Resources;improved;Ingestion;innovation;insight;Insulin-Dependent Diabetes Mellitus;knowledge graph;knowledgebase;novel therapeutics;open data;Pancreas;Persons;programs;Research;software systems;Textiles

PROJECT_TITLE: Connecting PanKbase knowledge graph with Proto-OKN


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Diabetes

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Current diabetes treatments are woefully inadequate, and diabetes remains a leading cause of disability and death among Americans. Our program will meet a growing need within our region and the country for a cohort of capable diabetes investigators, by training new scientists in cutting edge research aimed at better treating and preventing diabetes. The trainees in this program will be scientists who are not yet independent but have earned their PhD and/or MD and intend to head their own diabetes research laboratories.

PI_NAMEs: NORRIS, ANDREW W (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Diabetes Mellitus;Research Training;Training Programs

PROJECT_TITLE: Diabetes Research Training Program

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: CLEMSON

ORG_DEPT: CHEMISTRY

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project Narrative Exosomes are now fully realized as being integral elements in many biological processes, first and foremost as conduits for inter-cellular communication. Key to their study and utilization across fundamental biochemistry, potential uses in clinical diagnostics, and realizing their promise as therapeutic drug delivery vehicles is the development of technologies that allow their rigorous, robust, efficient and inexpensive isolation and purification across many size scales and source matrices. Capillary-channeled polymer (C-CP) fiber and film platforms address these challenges in a unified way that provides continuity and simplicity across these fields of endeavor, holding the promise of advancing the knowledge base and applications of these important extracellular vesicles.

PI_NAMEs: BRUCE, TERRI LANE FOSTER;MARCUS, RICHARD KENNETH (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: 3D Print;Address;Affect;Aliquot;Antibodies;aptamer;base;Basic Science;Benchmarking;Biochemistry;Biological;Biological Assay;Biological Markers;Biological Process;Blood capillaries;Cell Culture Techniques;Cell Line;cell type;Cells;Cellular biology;Characteristics;Chemicals;Clinical;clinical diagnosis;clinical diagnostics;Column Chromatography;Communication;Communities;Complex;cost;cost effective;Coupled;Culture Media;delivery vehicle;design;Development;Diagnosis;Diagnostic tests;Diameter;Disease;disease diagnostic;Drug Delivery Systems;Elements;Environment;Ethylenes;Exhibits;exosome;Experimental Models;extracellular vesicles;Fiber;Film;fluid flow;fundamental research;Harvest;High Pressure Liquid Chromatography;Home;Image;Immobilization;Immunoassay;instrumentation;intercellular communication;interest;knowledge base;Laboratories;Lateral;Liquid substance;Membrane Proteins;meter;Methodology;Methods;new technology;novel;parallel processing;peer;Performance;Permeability;Phase;Plasma;Polymers;Population;Positron-Emission Tomography;Program Development;programs;protein biomarkers;Proteins;Proteomics;prototype;Provider;Rapid diagnostics;Recovery;Reproducibility;Research;research and development;Sampling;Scientific Evaluation;Shapes;Source;Surface;System;technology development;technology platform;terephthalate;Therapeutic;transcriptome sequencing;Urine;Validation;vector;Vesicle;Virion;Western Blotting

PROJECT_TITLE: Capillary-channeled polymers fibers and films - A platform technology for exosome isolation and analytics

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: WASHINGTON

ORG_NAME: AMERICAN SOCIETY OF NEPHROLOGY, INC.

ORG_STATE: DC

PHR: RFA-FD-24-041 Project Narrative The Kidney Health Initiative (KHI) is a public-private partnership among the American Society of Nephrology (ASN), the US Food and Drug Administration (FDA), and the kidney community whose mission is to catalyze innovation and the development of safe and effective drugs, devices, and biologics for people with kidney diseases. KHI is a pre-competitive forum that convenes a multi-sector community, including all the major constituencies in this field (people with kidney diseases and care partners/patient advocates, health professionals, members of industry and government), to exchange knowledge and execute pre-competitive collaborations that address shared challenges. KHI’s focused projects and initiatives result in peer-reviewed manuscripts, and widely- disseminated roadmaps, workshops, roundtables, webinars, and educational toolkits that provide recommendations and direction for any individual, company, or organization to use for the development of new kidney drugs, devices, and biologic therapies.

PI_NAMEs: IBRAHIM, TOD RAMSES (contact)

PROGRAM_OFFICER_NAME: PEASE-FYE, MEG

PROJECT_TITLE: Kidney Health Initiative is a public-private partnership between the American Society of Nephrology, US Food and Drug Administration and the kidney community.

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-T (14)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative Climate Change is relevant to food production, water access, energy use, and health. Diet is related to crop production and food security, which is impacted by weather patterns in terms of precipitation, temperature, and drought. Less developed countries and their disadvantaged communities are most vulnerable yet we do not have a good understanding of these risks. To understand the connection of diet access and quality in low income rural communities to these environmental factors, our study assesses dietary behavior and health outcomes in rural Jordan that can help us develop policies and interventions to protect these communities from the impacts of these factors.

PI_NAMEs: AL-DELAIMY, WAEL K (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Address;Administrative Supplement;Affect;agricultural community;Agricultural Crops;Agriculture;Area;Chronic Disease;Climate;climate change;climate impact;climate-related health;Clinical;Clinical Nutrition;Communities;community engagement;community organizations;Complement;Complex;coping;Data;data access;Developing Countries;Diet;dietary;Dietary Assessment;Dimensions;Disadvantaged;Disease;drinking water;Droughts;Environmental Risk Factor;Event;experience;extreme temperature;extreme weather;Fabaceae;Family;Farm;Farming Community;fast food;Floods;Food;food consumption;Food Energy;food insecurity;Food Preservation;Food production;food quality;Food Safety;food security;fruits and vegetables;global temperature;Global Warming;graduate student;Grant;Health;Health behavior and outcomes;Health Food;Health system;Heat Waves;High temperature of physical object;Home;Human;Hurricane;Income;insight;interdisciplinary approach;Intervention;Jordan;Life;Link;Low income;Maps;Measures;Methods;Modeling;Municipalities;neighborhood disadvantage;Nutrient;nutrition;Outcome;parent grant;Parents;Pathway interactions;Persons;Policies;poor communities;Population;Poverty;Precipitation;Process;Production;recruit;Refrigeration;Refugees;Research;Resources;Risk;Risk Factors;Rural;Rural Community;Scientist;sea level rise;Source;Target Populations;Temperature;text searching;tool;Training;vulnerable community;Vulnerable Populations;wasting;Water;water quality;weather patterns;Wildfire

PROJECT_TITLE: Global Center on Climate Change and Water Energy Food Health Systems


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Pediatric;Rehabilitation

ORG_CITY: Broomfield

ORG_NAME: POINT DESIGNS, LLC

ORG_STATE: CO

PHR: PROJECT NARRATIVE Point Designs proposes to develop and commercialize a purely mechanical, ratcheting prosthetic finger system for children with partial hand limb absence – independent from electronics and batteries, thereby reducing cost, size, and complexity while increasing reliability and durability – that can be custom-made for each patient using advanced metal 3D-printing technology. Partial hand limb absence can cause physical, psychosocial, and economic damage to a child and their family. Replacement of a finger requires a mechanical design that can withstand the demanding forces, torques, and environmental conditions of everyday life.

PI_NAMEs: SLIKER, LEVIN  (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: 3D Print;adolescent health;Adult;Algorithms;Amputation;Anatomy;Child;Child Health;Child health care;Childhood;Clinic;Clinical;cohort;Colorado;commercialization;Communities;cost;Custom;Data Set;design;design verification;Development;Devices;Digit structure;disability;Disabled Persons;economic impact;Economics;efficacy evaluation;Electronics;Emotional;Ensure;Environment;experience;Face;Failure;Family;Fingers;Friction;functional improvement;Goals;Hand;hand dysfunction;health care settings;Home;Impairment;improved;indexing;Individual;Industry;innovation;Interview;Laboratories;Lactation;Lateral;Length;Life;Life Style;limb loss;Limb Prosthesis;Limb structure;manufacture;manufacturing technology;Measurement;Measures;Mechanics;Medical;Metacarpophalangeal joint structure;Metals;Mission;National Institute of Child Health and Human Development;Occupational Therapist;Outcome Measure;Parents;patient population;Patients;pediatric patients;personalized approach;Persons;Phase;Population;pregnant;primary outcome;Prosthesis;Prosthesis Design;prosthetic hand;Protocols documentation;prototype;Psychological Impact;psychosocial;Quality of life;recruit;Rotation;satisfaction;simulation;social;Social Impacts;sound;Source;Strategic Planning;System;Technology;Testing;therapeutically effective;Titanium;Torque;transition to adulthood;Universities;Upper Extremity;validation studies;verification and validation;Weight;Woman;Work

PROJECT_TITLE: A ratcheting pediatric prosthetic finger using advanced rapid manufacturing technology


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_DEPT: PHARMACOLOGY

PHR: Narrative Statement We propose continuation of M-CERSI that fosters FDA-oriented research, as well as regulatory science information sharing opportunities. The Center's mission is to foster the development of regulatory science – the science of developing new tools, standards and approaches to assess the safety, efficacy, quality and performance of FDA-regulated products. Activities leverage the close geographic proximity between University of Maryland and FDA's main campus.

PI_NAMEs: BENTLEY, WILLIAM E.;POLLI, JAMES E (contact)

PROGRAM_OFFICER_NAME: SEPULVEDA, KRISTIN

PROJECT_TITLE: University of Maryland Center of Excellence in Regulatory Science and Innovation


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Chronic Pain;Neurosciences;Pain Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Chronic pain represents a major public health problem, and an improved understanding of the biopsychosocial contributors to pain is critical to inform interventions aimed at pain prevention and treatment. At present, there is a need to bolster the dwindling clinical pain research workforce. To address this gap, we propose the University of Florida Partnerships Across Interdisciplinary Networks: Training through Engineering, epidemiology & Addiction Medicine (UF PAIN TEAM} with the long-term goal of creating the next generation of team-trained clinical pain scientists. Working in teams, the UF PAIN TEAM will move the pain field forward through cutting edge research designed to elucidate the causes and reduce the burden of pain.

PI_NAMEs: ALLEN, KYLE D;CRUZ-ALMEIDA, YENISEL  (contact)

PROGRAM_OFFICER_NAME: LENZI, REBECCA N

PROJECT_TERMS: addiction;Applied Skills;Appointment;Area;biopsychosocial;career;career development;chronic pain;Clinical;clinical pain;Clinical Sciences;cohort;Collaborations;Communities;comorbidity;design;Development;Discipline;Doctor of Philosophy;effective intervention;Elements;Engineering;Epidemiology;experience;Faculty;Florida;Future;Goals;health equity;high standard;Knowledge;life span;Medicine;Mentors;Modeling;next generation;non-opioid analgesic;Nonpharmacologic Therapy;Pain;Pain management;pain model;Pain Research;Pharmacological Treatment;post-doctoral training;Postdoctoral Fellow;Prevention;programs;Research;Research Personnel;Research Training;response;responsible research conduct;Science;Scientist;skills;social health determinants;Training;Training Programs;Translating;Universities;Work

PROJECT_TITLE: University of Florida Partnerships Across Interdisciplinary Networks: Training through Engineering, epidemiology & Addiction Medicine (UF PAIN TEAM)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Infectious Diseases;Lung

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Immune cells in the lung have important functions both during infection and homeostasis. Their appropriate function in either context involves transmitting signals from lung microenvironment, and improper integration of these signals can lead to impaired pathogen clearance or excess inflammation and tissue damage. Our goal is to understand mechanisms that allow lung signals to shape immune function, to gain insights into susceptibility to infection and chronic inflammatory lung diseases.

PI_NAMEs: GOTTSCHALK, RACHEL A (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute;Alveolar Macrophages;Anti-Inflammatory Agents;Bacterial Infections;Bacterial Pneumonia;Bone Marrow;cell type;Cells;chronic inflammatory lung disease;Chronic lung disease;cytokine;Cytokine Signaling;Development;Disease;Equilibrium;Event;Family;functional plasticity;Gases;Genes;Genetic Transcription;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Health;Homeostasis;Human;Immune;immune function;Immune response;Immunosuppression;Impairment;Infection;Inflammation;Inflammatory;Inflammatory Response;insight;Insulin-Like Growth Factor I;knock-down;Link;lipid metabolism;Lipids;Lung;Lung infections;Macrophage;MAP Kinase Gene;Metabolic;Metabolism;microbial;Minor;Modeling;Morbidity - disease rate;mortality;Mus;Mutation;pathogen;Pathology;pharmacologic;Phenotype;Phosphotransferases;Post-Translational Protein Processing;PPAR gamma;Predisposition;preference;Process;programs;Proteins;Proto-Oncogene Proteins c-akt;Pseudomonas aeruginosa;Pulmonary Alveolar Proteinosis;Pulmonary Surfactants;Recurrence;Resolution;Respiration;response;Role;Science;Shapes;Signal Pathway;Signal Transduction;Staphylococcus aureus;Stimulus;Structure of parenchyma of lung;Therapeutic;Tissues;transcription factor;transcriptome sequencing;transmission process;Upper Respiratory Infections;Variant;Work

PROJECT_TITLE: Linking steady-state cytokine signaling to alveolar macrophage function in homeostasis and lung infection

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: Project Narrative Loss of vestibular function with aging affects both balance and gait and is thought to contribute to increased fall risk. Recently, we have found that very low levels of random electrical stimulation applied to the vestibular system produce improvements in vestibular function along with balance and gait measurers in elderly individuals with age related vestibular loss. The present work aims to test if this novel subperceptual neuromodulation stimulus can be used as an effective treatment for age related vestibular loss that will improve balance confidence, balance and gait, in the hopes of reducing fall risk.

PI_NAMEs: SERRADOR, JORGE M. (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Affect;Age;age effect;age related;Aging;Awareness;Data;Devices;disability;Disease;Double-Blind Method;effective therapy;efficacy testing;Elderly;Electric Stimulation;Equilibrium;fall risk;falls;Frequencies;functional improvement;Gait;Goals;Health;Hour;improved;Individual;Knowledge;Mediating;mortality;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurons;Neurophysiology - biologic function;neuroregulation;neurotransmission;normal aging;novel;Older Population;Participant;Pathologic;Placebo Control;placebo group;Population;Quality of life;randomized controlled design;Reflex action;Rehabilitation therapy;response;Stimulus;Testing;Translating;Vestibular function;Vestibular loss;vestibular system;Work

PROJECT_TITLE: Novel Neuromodulation Treatment of Age Related Vestibular Loss to Improve Balance and Gait in Elderly Individuals


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: CHARLESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Project Narrative Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers and is characterized by an expansion of fibroblasts which modulate the tumor microenvironment. This proposal aims to elucidate molecular signatures and functions of cancer associated fibroblast subtypes in PDAC. This research will contribute to fundamental knowledge of PDAC biology, and may ultimately lead to design of more effective therapeutics for PDAC patients.

PI_NAMEs: HAN, LU  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Acceleration;Adult;Agonist;Alleles;antagonist;anti-cancer research;Biological;Biology;Bone Marrow Cells;Cancer Biology;Cancer Center;cancer subtypes;cancer type;Cells;Characteristics;Coculture Techniques;Complex;conditional knockout;Correlation Studies;Data;design;Developmental Biology;Diagnosis;Disease;effective therapy;Embryology;Endoderm;Epithelial Cells;Epithelium;Erinaceidae;experimental study;fetal;Fetal Development;fetal stem cell;Fibroblasts;FOXF1 gene;Future;Gene Deletion;Gene Expression;Gene Expression Profile;Genetic;Genetically Engineered Mouse;Heterogeneity;Human;Immune;In Vitro;in vivo;insight;Knowledge;KRASG12D;Ligands;Light;Malignant neoplasm of pancreas;Malignant Neoplasms;Mesenchymal;Mesenchyme;Modeling;Molecular;Molecular Profiling;mouse model;Mus;neoplastic cell;novel;Oncology;Organ;Organoids;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic tumorigenesis;Paracrine Communication;Pathogenesis;Pathway interactions;Patients;Pattern;Phase;Physiology;Play;Postdoctoral Fellow;programs;Regulation;Research;restraint;Role;Sampling;skills;smoothened signaling pathway;stem;success;targeted treatment;Testing;Therapeutic;therapeutically effective;Tissues;Training;transcription factor;treatment response;treatment strategy;tumor;Tumor Burden;tumor microenvironment;tumor progression;Tumor-Derived

PROJECT_TITLE: Origin, diversification and function of pancreatic cancer associated fibroblasts

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Project Narrative This project will assess the impact of a novel breastfeeding support intervention (“telelactation”), delivered via video calls on personal devices including mobile phones and tablets. The goal of this intervention is to increase access to International Board Certified Lactation Consultants to improve, and reduce disparities in, breastfeeding rates. By implementing a “siteless” randomized controlled trial that recruits participants through a popular pregnancy tracker mobile phone application, this study will efficiently recruit a national sample of 2400 diverse women to 1) provide evidence on the effectiveness of a widely available, yet understudied, service and 2) leverage technology to promote one of the most widely recommended health behaviors to improve children’s health and to reduce disparities in key maternal and child health outcomes.

PI_NAMEs: USCHER-PINES, LORI  (contact)

PROGRAM_OFFICER_NAME: LONG, SYLVIA ELISABETH

PROJECT_TERMS: Address;Age;Age Months;American;Black race;black women;Board Certification;Breast Feeding;Case Study;Cellular Phone;Child Health;Communities;compare effectiveness;Consult;cost;Data;Dedications;design;Devices;Diet;Disparity;disparity reduction;Effectiveness;effectiveness evaluation;eHealth;ethnic minority;Ethnic Minority Women;Ethnic Origin;Ethnic Population;experience;Exposure to;Future;Goals;Health;Health behavior;health disparity;Home;Human Milk;improved;Infant;innovation;International;Intervention;Interview;Lactation;Lactation consultant;Latina;Link;Maternal and Child Health;Mediating;Mediator;Medical;Methods;Minority;minority communities;Minority Participation;Minority Women;Modeling;Mothers;novel;Observational Study;Office Visits;Outcome;Patient Recruitments;Patients;pediatrician;Pennsylvania;Persons;Pilot Projects;Policies;poor health outcome;Positioning Attribute;Postpartum Period;Postpartum Women;preference;Pregnancy;Pregnant Women;Provider;Publishing;Race;racial minority;racial minority women;racial population;Randomized;randomized controlled design;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;Research;Resources;Risk;Rural;Rural Community;Sampling;satisfaction;Self Efficacy;Services;Surface;Surgeon;Surveys;Tablets;Technology;telelactation;Time;Training;Travel;treatment as usual;Underserved Population;urban area;video chat;Videoconferencing;virtual;Visit;White Women;Woman

PROJECT_TITLE: The Impact of Telelactation Services on Breastfeeding Outcomes among Minority Mothers: Siteless Tele-MILC Trial

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Autism Spectrum Disorder affects 1 and 44 children, and racial/ethnic disparities profoundly impact access to care. Though most research has focused on child and family factors, other contextual factors such as neighborhood, state health policy, and educational system determinants are likely drivers of structural disparities in care. In this research we propose to identify cross-sector, modifiable determinants of autism diagnostic and treatment disparities by combining Medicaid data with information on neighborhoods, state policy, and state educational data, and we will use a stakeholder-engaged consensus panel to turn data into actionable interventions.

PI_NAMEs: LINDLY, OLIVIA J;ZUCKERMAN, KATHARINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: 3 year old;access disparities;Address;adolescent with autism spectrum disorder;adult with autism spectrum disorder;Affect;Age;Alaska Native;American Indians;Autism diagnostic;autism spectrum disorder;autistic children;Automobile Driving;base;Behavior Therapy;behavioral health;Big Data;Black race;Caring;Cessation of life;Child;Child health equity;child services;Childhood;children of color;Chronic;Communities;community based service;Complex;Consensus;contextual factors;Data;Data Aggregation;Data Analyses;data harmonization;data quality;Data Science;Data Set;Development;Diagnosis;Disparity;Disparity in diagnosis;disparity reduction;Early Intervention;Education;Equity;ethnic disparity;Ethnic Origin;evidence base;Family;Family member;Funding;General Population;Guidelines;Health;health care disparity;Health Disparities Research;health equity;health inequalities;Health Policy;Health Services;Health Services Accessibility;Health system;Healthcare;Home;improved;improved outcome;indexing;individuals with autism spectrum disorder;Information Systems;innovation;interest;Intervention;intervention program;Knowledge;life span;lower income families;Machine Learning;Measures;Medicaid;Medicine;Methods;National Institute of Mental Health;Neighborhoods;Nursery Schools;Pharmaceutical Preparations;Policies;Policy Maker;Prevalence;programs;psychopharmacologic;Race;racial determinant;racial disparity;Recommendation;Research;Research Personnel;Schools;screening;secondary analysis;Services;social;Special Education;Strategic Planning;structural health determinants;System;Techniques;treatment disparity;United States;United States National Institutes of Health;waiver;Work

PROJECT_TITLE: Addressing Structural Disparities in Autism Spectrum Disorder through Analysis of Secondary Data (ASD3)


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pain Research;Precision Medicine;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Temporomandibular Disorders (TMD) including those involving the temporomandibular joint (TMJ) itself represent a spectrum of painful disorders that afflicts approximately 5 to 10% of the US population with approximate annual healthcare costs of $4 billion. No definitive etio-pathologic diagnostics are currently available, and treatments are non-specific and largely palliative. By deep dissection of the local and systemic molecular profiles and cellular interactions using single cell multi-omics we expect to provide comprehensive foundations and depth of knowledge needed to more rationally stratify patients into TMJ disorder (TMJD) and comorbidity subtypes and severity categories; provide the basis for new directions of translational science in diagnostics, prognostics and therapeutics towards the implementation of precision medicine; define homeostatic and disease signatures that are specific to the TMJ as opposed to appendicular joints; and lay the foundation for further studies on the biologic mechanisms underpinning TMJDs, pain and dysfunction.

PI_NAMEs: ARONOVICH, SHARON ;BHUTANI, NIDHI ;KAPILA, SUNIL D (contact);PELLEGRINI, MATTEO ;WONG, DAVID T

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Age;Arthralgia;Biological;Biological Assay;Biological Markers;Biology;Blood specimen;Calibration;case control;Categories;Cells;Classification;Clinical;clinical phenotype;Clinical Research;cohort;Collection;comorbidity;Complex;Computational Biology;Country;Data;data integration;data management;data standards;Degenerative Disorder;Degenerative polyarthritis;design;Diagnostic;Disease;disease phenotype;Disease Progression;disorder subtype;Dissection;DNA Methylation;epigenomics;Fibromyalgia;Foundations;Functional disorder;Goals;Headache;Health Care Costs;healthy volunteer;Image;indexing;Individual;insight;Joints;Knowledge;Localized Disease;Machine Learning;Manuals;Methods;Molecular;Molecular Profiling;Multiomic Data;multiple omics;Musculoskeletal Diseases;novel;Operative Surgical Procedures;Pain;palliative;Pathologic;Pathway interactions;Patient Recruitments;patient stratification;Patients;Phase;Phenotype;Pilot Projects;Population;precision medicine;Precision therapeutics;Prevention;Procedures;Productivity;prognostic;proteomic signature;Protocols documentation;quality assurance;Quality of life;recruit;Reproducibility;reproductive;Research Design;Research Personnel;response;Retrieval;RNA methylation;Saliva;Salivary;sample collection;Sampling;Services;Severities;Severity of illness;Site;sound;Standardization;success;Symptoms;Synovial Cell;Synovial Fluid;System;Temporomandibular Joint;Temporomandibular joint disorder pain;Temporomandibular Joint Disorders;Testing;Therapeutic;Tissues;transcriptomics;Translational Research;Woman;Work

PROJECT_TITLE: Local and Systemic Multi-Omics of TMJ Disorders


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Precision Medicine;Rural Health

ORG_CITY: MARSHFIELD

ORG_NAME: MARSHFIELD CLINIC RESEARCH FOUNDATION

PHR: Data collected as part of AoURP is not about one single disease or even a class of diseases; it is about all diseases that can impact the health and wellbeing of all Americans. This resource will foster academic freedom, transparency, and be a trusted dataset for the public and scientists alike.

PI_NAMEs: BURNSIDE, ELIZABETH S;CADMUSBERTRAM, LISA ANNE;FRANCO, ZENO E;HEBBRING, SCOTT JOSEPH (contact);MAHR, TODD A;SHUKLA, SANJAY K

PROGRAM_OFFICER_NAME: ALEXANDER-TROUPE, STEPHANIE MELANIA

PROJECT_TERMS: Academy;Acceleration;Adult;Advocacy;Advocate;All of Us Research Program;American;Ancillary Study;Appointment;Area;Asian population;Awareness;biobank;Biomedical Research;Black race;care delivery;care providers;career;Caring;Censuses;Childhood;Clinic;Collaborations;Collection;Communities;community center;community partners;Complex;Computer Literacy;Computers;Consent;Consent Forms;COVID-19 pandemic;Data;Dedications;demographics;Development;disability;Disease;Education;Electronics;Eligibility Determination;Enrollment;Ensure;Environment;Ethics;ethnic diversity;Ethnic Origin;experience;Faith;Family;flexibility;follow-up;Friends;Frontline worker;Genetic;Geography;Health;Health Campaign;health care service organization;Health Personnel;Health system;Healthcare;Healthcare Systems;Hispanic;Hospitals;Hour;Household;human disease;human old age (65+);illiteracy;Indigenous;Individual;individualized prevention;Infrastructure;innovation;Inpatients;Institution;Institutional Review Boards;Intake;Integrated Health Care Systems;interest;Intuition;Letters;Life Style;Link;literacy;Location;Measurement;Medical;medical schools;meetings;member;Mental Health;migration;Minority Groups;Mission;Modeling;Mothers;Native American population;Newborn Infant;Older Population;Outpatients;outreach;pandemic disease;Paper;Parents;Participant;participant enrollment;participant retention;Pediatric Hospitals;pediatrician;Pediatrics;Pharmacy facility;Population;Population Heterogeneity;Positioning Attribute;Precision Health;precision medicine;precision nutrition;Process;Productivity;programs;Provider;racial diversity;Recontacts;recruit;Refugees;Research;Research Personnel;Research Training;retention rate;retiree;Rural;rural area;Rural Population;Scientist;Site;social;Social Work;Societies;Source;Southeastern Asia;Special Population;success;Surveys;Technology;Time;United States;United States National Institutes of Health;Universities;Urban Community;Vietnam;Visit;Walking;War;Wisconsin;Youth

PROJECT_TITLE: AOU WI Area of Interest 1: Community, Participant and Provider Engagement, Enrollment...


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because elderly patients with mild cognitive impairment and early-stage dementia are frequently underdiagnosed, posing significant burden on patients, families, and healthcare systems. Development of a novel screening algorithm built on easily accessible data generated in routine patient-clinician encounters has a strong potential to identify these patients, promoting timely care and preventing negative outcomes, particularly emergency department visits and hospitalizations. The proposed study is aligned with one of the National Institute of Aging’s Strategic Directions for Research (2020-2025), “Develop improved approaches for the early detection and diagnosis of disabling illnesses and age-related debilitating conditions.”

PI_NAMEs: ZOLNOORI, MARYAM  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Accident and Emergency department;Address;Affect;Age;age related;Algorithms;Asthma;Attention;Biological Markers;Biometry;care costs;Care given by nurses;career development;Caring;Cerebrospinal Fluid;Clinical;clinical care;Clinical Data;clinical encounter;Cognitive;cognitive function;Communication;Competence;cost;daily functioning;Data;Data Science;Data Set;data streams;Dedications;Dementia;Development;Diagnosis;Disabling;early detection biomarkers;Early Diagnosis;Early identification;Electronic Health Record;electronic health record system;Emergency department visit;Evaluation;executive function;Family;Goals;health care service;health care service utilization;health care settings;health record;Healthcare;Healthcare Systems;Home Care Services;Hospitalization;Impaired cognition;improved;Informatics;innovation;Intervention;Language;language impairment;Life Style;Medical Care Team;Memory impairment;Mentorship;Methods;mild cognitive impairment;Modeling;Motor;motor disorder;National Institute on Aging;Natural Language Processing;New York;novel;Nurses;Nursing Services;older adult;older patient;Outcome;Patient Admission;Patient Care;Patients;Performance;Pharmaceutical Preparations;Phase;Phonetics;Pilot Projects;Postdoctoral Fellow;pre-doctoral;prevent;programs;Property;provider communication;Public Health;Quality of life;Recording of previous events;Research;Research Personnel;Research Priority;Resources;Risk;Risk Factors;Risk Reduction;Scientist;screening;Screening procedure;Semantics;Services;showing emotion;skills;Speech;Structure;Symptoms;System;Systems Analysis;Techniques;Testing;Text;theories;Time;Training;Universities;verbal;Visiting Nurse;Work

PROJECT_TITLE: Development of a Screening Algorithm for Timely Identification of Patients with Mild Cognitive Impairment and Early Dementia in Home Healthcare

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Lewy body dementia affects men and women differently, as sex differences have been reported for prevalence, clinical phenotype, and presence of co-pathologies. Understanding the genetic and neuropathologic mechanisms associated with these sex differences will helpelucidate the etiopathogenesis of this dementia. Identification of sex-specific genetic and neuropathologic factors in Lewy body dementia will improve diagnostic accuracy at an early stage, provide reliable biomarkers and promising targets for precision medicine.

PI_NAMEs: BAYRAM, ECE  (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Acceleration;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Apolipoprotein E;Award;Big Data;Bioinformatics;Biological Markers;Body Burden;Brain;California;career;Clinic;Clinical;clinical diagnosis;clinical diagnostics;clinical phenotype;clinical predictors;Clinical Research;Clinical Trials;Cognition;Cognitive;cohort;Data;Data Set;Dementia;dementia risk;Dementia with Lewy Bodies;Development;Diagnosis;diagnosis standard;diagnostic accuracy;disease phenotype;Doctor of Philosophy;Elderly;Endosomes;experience;Five-Year Plans;Foundations;Frequencies;Functional disorder;Funding;Future;Genetic;genetic predictors;Genetic Risk;genetic risk factor;genetic variant;genome sequencing;Genomics;Goals;Heterogeneity;Hippocampus;Impaired cognition;improved;Individual;Institution;Leadership;Lewy Bodies;Lewy Body Dementia;Lewy body pathology;Life;medial temporal lobe;Medicine;men;Mentors;Modeling;morphogens;Movement Disorders;National Institute of Neurological Disorders and Stroke;neocortical;Nerve Degeneration;neurodegenerative dementia;Neurodegenerative Disorders;neuroimaging;Neurologist;neuropathology;Neuropsychology;non-demented;Parkinson Disease;Parkinsonian Disorders;Pathologic;Pathologist;Pathology;Pathway interactions;Patient Selection;Patients;Phase;Phenotype;Positioning Attribute;Positron-Emission Tomography;precision medicine;predictive modeling;Prevalence;Productivity;public-private partnership;Recording of previous events;regional difference;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Resources;risk variant;Salmon;Sampling;Scientist;Senile Plaques;Series;sex;Sex Differences;skill acquisition;skills;Statistical Data Interpretation;success;Symptoms;tau Proteins;Training;Translational Research;United States National Institutes of Health;Universities;Visual Hallucination;whole genome;Woman;Work

PROJECT_TITLE: Genetic and Neuropathologic Underpinnings of Sex Differences in Lewy Body Dementias


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Physical Activity;Prevention

ORG_CITY: UNIVERSITY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI

ORG_STATE: MS

PHR: PROJECT NARRATIVE  Although regular physical activity comes with many health benefits, including lower risk of disability and chronic disease, higher functional independence, and greater psychological well-being, many US adults— especially those in later life—do not obtain sufficient levels of activity based on federally recommended guidelines. This project uses data captured repeatedly and intensively in daily life to examine whether negative beliefs about aging result in less physical activity by hampering exercise motivations and self-regulation. Knowledge gained from this work will inform the development of interventions that target negative beliefs about aging to improve physical activity in older adults.

PI_NAMEs: O'BRIEN, ERICA LEE (contact)

PROJECT_TERMS: Address;Adopted;Adult;Affect;Age;age difference;Aging;aging process;aging related;Award;Behavior;behavior change;Behavioral;Belief;career;career development;Career Transition Award;Chronic Disease;Cognitive;college;Coupling;Data;design;Development;Development Plans;Devices;diaries;disability;disability risk;Disease;driving force;Ecological momentary assessment;effective intervention;Elderly;Environment;Exercise;expectation;Five-Year Plans;Foundations;functional decline;functional independence;Funding;Future;Grant;Guidelines;hands-on learning;Health;Health behavior;Health Benefit;Health Promotion;Human Development;human old age (65+);improved;Individual;Individual Differences;Informal Social Control;innovation;insight;Institution;Intervention;Knowledge;late life;Leadership;learning strategy;Life;Link;Measurement;Measures;Mediating;Medical;Mentorship;Methodology;Methods;middle age;mobile computing;mortality;Motivation;Nature;normal aging;novel;older adult;Older Population;Outcome;Pathway interactions;Patient Self-Report;Pennsylvania;Persons;Phase;Physical activity;Physical assessment;physical impairment;Population;Postdoctoral Fellow;Premature Mortality;Preparation;Prevention;programs;psychologic;psychosocial;Public Health;Qualifying;Quality of life;Recommendation;Reporting;Research;Research Personnel;Risk Factors;Scientist;sedentary;Self Efficacy;Self Perception;skills;social;Techniques;Technology;Testing;theories;therapy design;therapy development;Time;Training;United States National Institutes of Health;Universities;Variant;wearable device;Well in self;Work

PROJECT_TITLE: Pathways Linking Negative Self-Views of Aging to Physical Activity in Daily Life: An Intensive Within-Person Approach


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: This project proposes to develop a novel measure of the unique financial impacts experienced by caregivers of people living with Alzheimer’s disease and related dementias. We will over-sample caregivers from three NIA priority populations – Hispanic/Latino, Black/African American, and people living in rural areas – to assure the measure is valid and reliable in the general population and in these groups. This project has the potential to positively impact public health by enabling us to understand caregiving financial impacts and the influence of social networks.

PI_NAMEs: BOULDIN, ERIN  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;African American;Alzheimer's Disease;Alzheimer's disease caregiver;Alzheimer's disease related dementia;Area;Black race;care costs;Caregiver support;Caregivers;caregiving;Caring;Communities;dementia care;design;Economics;Employment Status;experience;Factor Analysis;Family;Family Caregiver;family caregiving;family support;Feedback;Financial Hardship;Financial Support;Future;General Population;geographic disparity;Goals;health disparity;Hispanic;Hispanic Populations;Home;Income;instrument;Internet;Interview;Latino;Lived experience;Measurable;Measures;Medical;Methods;Modification;National Institute on Aging;novel;Occupational activity of managing finances;Outcome;Participant;Personal Satisfaction;Persons;Policies;Population;Process;Property;Psychometrics;Public Health;racial disparity;Research;Research Personnel;response;Role;Rural;rural area;Sampling;social influence;Social Network;Spanish/English;Structure;Surveys;Telephone;Testing;therapy development;Validation;Validity and Reliability;Work

PROJECT_TITLE: Financial Impact of Support and Care in Alzheimer's disease and Related Dementias (FISCAL)


NIH_SPENDING_CATS: Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The Johns Hopkins University seeks to strengthen the coordination of new and innovative research and practice efforts in maternal health through collaboration with the National Institutes of Health and their Implementing a Maternal Health and Pregnancy Outcomes Vision for Everyone (IMPROVE) initiative grantees. The overarching goals of this project are to establish and maintain a Maternal Health Data Innovation and Coordination Hub to support Maternal Health Research Centers of Excellence, and to facilitate the reuse of the data they generate.

PI_NAMEs: CREANGA, ANDREEA ALINA (contact);NAGY, PAUL GREGORY

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Area;Artificial Intelligence;Award;Bioethics;career development;Centers of Research Excellence;Clinical;cloud based;Collaborations;Common Data Element;Communication;Communities;Data;Data Analyses;Data Collection;data hub;data integration;data modeling;data repository;data reuse;Data Science;Data Set;data sharing;Data Storage and Retrieval;Development;Documentation;Equity;Evaluation;experience;FAIR principles;Family;Fostering;Funding;Generations;Goals;health data;health disparity;health economics;health equity;Human;implementation science;improved;Informatics;Infrastructure;Ingestion;innovation;interest;Knowledge;Machine Learning;Maternal Health;Medical;medical schools;Mentorship;Methods;multidisciplinary;Observational Study;Ontology;open source;Outcome;patient safety;Patients;Peer Review;Population Heterogeneity;precision medicine;Pregnancy Outcome;Preparation;Process;programs;Public Health Schools;quality assurance;Recommendation;Registries;Reporting;repository;Reproducibility;Research;Research Project Grants;Research Support;Resources;Scholarship;Secure;Security;Site;skills;Specialist;Standardization;Statistical Data Interpretation;symposium;Techniques;Terminology;tool;Training;United States National Institutes of Health;Universities;Vision;web site

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: WHITE PLAINS

ORG_NAME: NATIONAL HEALTH PROMOTION ASSOCIATES

PHR: NARRATIVE This Fast-Track SBIR proposal is designed to address the critical public health problem of bullying and cyberbullying among elementary school age youth. We will develop and test bullying and cyberbullying prevention materials, including interactive classroom sessions and corresponding serious games, based on the evidence-based Life Skills Training substance abuse prevention approach, which teaches personal self- management skills, social skills, refusal skills, and other life skills needed to successfully navigate developmental tasks, increase resilience, and facilitate healthy psychosocial development. The proposed product has the potential to fill a gap in the intervention tools currently available to schools that can be widely disseminated throughout the country using existing marketing and dissemination channels and decrease the adverse consequences of bullying, cyberbullying as well as substance abuse.

PI_NAMEs: WILLIAMS, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: PARSAFAR, PARISA

PROJECT_TERMS: Address;adverse outcome;Age;Aggressive behavior;Attitude;Behavior;Behavioral;bullying;bullying prevention;commercialization;Community Practice;Control Groups;Country;cyberbullying;Data;design;Development;digital health;Disadvantaged;E-learning;Education;Educational Curriculum;Educational process of instructing;effective intervention;Effectiveness of Interventions;effectiveness testing;elementary school;evidence base;Feedback;flexibility;Focus Groups;follow up assessment;Funding;Goals;group intervention;Health education;Health Technology;high risk;Intervention;Knowledge;Learning Module;Life;Marketing;Mental Health;Modeling;Monitor;multi-component intervention;Outcome;parenting intervention;Parents;peer;Peer Review;perpetrators;Persons;Pharmaceutical Preparations;Phase;Prevention;Prevention approach;Prevention program;Primary Prevention;process evaluation;programs;promote resilience;protective factors;prototype;Provider;psychosocial development;Public Health;Publications;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Reporting;Request for Applications;Research;Resources;Risk Factors;school health;School-Age Population;Schools;Self Management;Series;skills;skills training;Small Business Innovation Research Grant;social;social skills;Students;substance abuse prevention;Substance abuse problem;substance use;substance use prevention;Teacher Professional Development;Testing;tool;Training;Training Programs;treatment as usual;usability;Verbally abusive behavior;Video Games;Youth

PROJECT_TITLE: Using Digital Health Technology to Prevent Bullying and Cyberbullying among Elementary School Students


NIH_SPENDING_CATS: Data Science;Dissemination and Implementation Research;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PI_NAMEs: GROSSMAN, ROBERT L. (contact)

PROGRAM_OFFICER_NAME: JUEHNE, ANTHONY LEE

PROJECT_TERMS: Agreement;anti-cancer research;Architecture;Area;Basic Science;Biological Assay;catalyst;Chicago;Child;Clinical Data;Clinical Trials;cloud based;Collection;Complex;Contracts;Data;data acquisition;Data Analyses;Data Commons;Data Coordinating Center;data ecosystem;data management;data platform;Data Reporting;data resource;Data Security;Data Set;data sharing;Data Sources;data tools;database of Genotypes and Phenotypes;design;Development;Discipline;Documentation;Ecosystem;Educational workshop;Ensure;Environment;FAIR principles;flexibility;Funding;Future;Genomic Data Commons;Grant;group competition;Helping to End Addiction Long-term;Heterogeneity;implementation framework;improved;Individual;Information Systems;large scale data;Laws;Link;Measurement;Metadata;Modality;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Drug Abuse;Observational Study;open source;opioid use disorder;Pain;Pain management;Pain Research;Participant;Patient Self-Report;petabyte;Phase;Policies;pre-clinical research;Procedures;programs;Regulation;repository;Research;Research Personnel;Research Project Grants;Research Support;Resources;Secure;Services;sharing platform;Source;System;Testing;Text;Time;Training;U-Series Cooperative Agreements;United States National Institutes of Health;Universities;Update;wearable device;webinar;Work

PROJECT_TITLE: Helping to End Addiction Long-term (HEAL) Data Platform


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative: The Case Western Reserve University MSTP will develop MD-PhD training to train a diverse pool of physician- scientists to meet future needs for research leaders who can accelerate research to advance the understanding, detection, treatment and prevention of human disease. We will develop an MD-PhD curriculum that integrates research and clinical training in a manner that deeply engages research training from the beginning of the program to promote retention of trainees in the research mission and foster curricular efficiency in time to completion of MD-PhD training. The integrated research and clinical curriculum, program activities, DEI focus and activities, and support for students will produce a highly skilled and diverse physician- scientist workforce, which will contribute to national goals for basic, translational and clinical research in academia, government and industry.

PI_NAMEs: BROIHIER, HEATHER ;HUANG, ALEX YEE-CHEN (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Medical Scientist Training Program at Case Western Reserve University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE – Overall Antibiotic resistance is one of the foremost public health concerns worldwide. This program to combat antibiotic resistance, which has as its goal to develop new approaches to treat antibiotic resistant infections by targeting the bacterial cell envelope, was specifically designed to be responsive to this global threat. A highly productive multidisciplinary team will function collaboratively to capitalize on the many advances it has already made to enable fundamentally new approaches that target this essential structure.

PI_NAMEs: WALKER, SUZANNE  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Anabolism;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;antimicrobial;Area;Bacteria;Bacterial Antibiotic Resistance;beta-Lactams;Biochemical;Biochemistry;Biogenesis;Biological;Biological Assay;Biology;cell envelope;Cell Maintenance;Cell Physiology;Cell Wall;Chemistry;Collaborations;collaborative approach;combat;Combating Antibiotic Resistant Bacteria;Complex;Creativeness;Cytolysis;Data;data sharing;design;Development;drug resistant pathogen;Ensure;Environment;experience;Family;Foundations;Genetic;genetic approach;Genetic Screening;Glycopeptide Antibiotics;Goals;Gram-Negative Bacteria;Growth;Immune;Individual;Infection;innovation;interdisciplinary collaboration;Investigation;Knowledge;Lipids;Macromolecular Complexes;Maintenance;Membrane;membrane assembly;membrane biogenesis;Membrane Proteins;Molecular;Molecular Genetics;mortality;multidisciplinary;Multiprotein Complexes;Natural Products;new therapeutic target;novel;novel strategies;Organism;pathogen;pathogenic bacteria;Pathway interactions;Peptidoglycan;Play;Polymerase;Polymers;Predisposition;Process;Productivity;programs;protein function;Proteins;Public Health;Reagent;reconstitution;Research Personnel;Resistance;resistant strain;response;Role;Scientist;Staphylococcus aureus;Streptococcus pneumoniae;structural biology;Structure;success;synergism;Technology;Teichoic Acids;Testing;Therapeutic;therapeutic target;tool;Training;Translational Research;Translations;Validation

PROJECT_TITLE: Exploiting membrane targets to overcome antibiotic resistance


PROJECT_TITLE: Project 2: Targeting Gram-positive Cell Envelope Assembly


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_STATE: MD

PI_NAMEs: COOPER, LISA A (contact);CREWS, DEIDRA CANDICE

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TITLE: The Mid-Atlantic Center for Cardiometabolic Health Equity (MACCHE)


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Pancreatic cancer is an aggressive and therapeutically difficult cancer to treat. Mouse models of pancreatic cancer are therefore paramount to our mechanistic understanding of tumor microenvironment dynamics and immunomodulatory interventions. The overall goal of this research is to use cutting-edge microscopy techniques to mechanistically understand the fine grain cellular interactions that dictate tumor responsiveness and leverage them to improve synergistic therapeutic strategies.

PI_NAMEs: MALTEZ, VIVIEN ILEANA (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Anti-CD40;Antibodies;Antigens;Apoptotic;Autoimmunity;Bacteria;Bacteriology;Cancer Etiology;cancer immunotherapy;cancer therapy;cancer type;Cause of Death;Cell Death;Cells;Cessation of life;chemotherapy;Clinic;Collaborations;Combination immunotherapy;comparative;cost effective;Dendritic Cells;Disease;Disparity;Doctor of Philosophy;Drug Targeting;effector T cell;Environment;Excision;Exclusion;experience;Frequencies;Goals;Grain;Histology;Human;Image;Immune;immune checkpoint blockade;Immune response;immunogenic;immunogenic cell death;Immunologic Techniques;Immunologics;Immunooncology;immunoregulation;improved;Infiltration;innovation;Intervention;Libraries;Lytic;Malignant neoplasm of pancreas;Malignant Neoplasms;Methodology;Methods;Microscopy;Modeling;mouse model;multiplexed imaging;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neighborhoods;neoplastic cell;new therapeutic target;novel;Operative Surgical Procedures;Outcome;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patients;Pennsylvania;Population;post-doctoral training;Postdoctoral Fellow;Productivity;programs;Public Health;rational design;recruit;Refractory;Regulatory Pathway;Reproducibility;Research;response;Risk;Role;spatiotemporal;standard of care;success;Survival Rate;Systems Biology;T-Lymphocyte;Technical Expertise;Techniques;Therapeutic;therapy outcome;therapy resistant;Tissues;tool;translational potential;tumor;Tumor Antigens;tumor heterogeneity;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;United States;Universities;Work

PROJECT_TITLE: Multiplex imaging in therapy refractory tumors: understanding the spatiotemporal facets of an immunosuppressive environment


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The role of hearing loss in health care outcomes such as delirium and health care utilization, possibly mediated via poor patient-provider communication and sensory deprivation pathways, is poorly understood. This study characterizes these associations in epidemiologic datasets and clinical samples and explores a low-cost, low- risk sustainable solution to address hearing loss in the inpatient setting. This Award lays the groundwork for large clinical trials that investigate systematically addressing hearing loss to improve health care outcomes and potential translation of research to improve patient-care for the millions of older adults with hearing loss.

PI_NAMEs: REED, NICHOLAS SALVATORE (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Admission activity;Adult;Aging;amplification device;Applications Grants;Atherosclerosis Risk in Communities;auditory stimulus;Award;beneficiary;Biometry;Brain;California;care outcomes;care seeking;career;Caring;Clinical;clinical practice;Clinical Research;Clinical Trials;cognitive load;Collaborations;Communication;Communication impairment;Confusion;cost;Data;Data Set;Dedications;Delirium;design;Development;Discipline of Nursing;Educational workshop;Environment;epidemiologic data;Epidemiology;epidemiology study;Equipment;Evaluation Research;experience;Faculty;Foundations;Funding;Gerontology;Goals;Head and Neck Surgery;Health;Health Care Costs;health care quality;health care service utilization;Health Policy;Health system;Healthcare;Healthcare Systems;Hearing;Hearing Aids;hearing impairment;hearing measurement;high risk;hospital readmission;Hospitalization;Hospitals;implementation measures;implementation science;improved;Incidence;Indiana;Inpatients;Instruction;Intervention;intervention program;Intervention Studies;Interview;K-Series Research Career Programs;Length of Stay;Link;Measurement;Measures;Mediating;Medical;medical schools;Medicare;Medicare claim;meetings;Mentors;Mentorship;Methodology;Methods;Modeling;Monitor;multidisciplinary;older adult;Otolaryngology;Outcome;Outcomes Research;Pamphlets;Pathway interactions;Patient Care;patient oriented;patient-clinician communication;Patients;Peripheral;Persons;pilot test;post implementation;Practice based research;Presbycusis;prevent;Prevention;Process;process evaluation;professor;programs;protective factors;Publications;Quality of Care;readmission rates;Research;responsible research conduct;Risk;Risk Factors;Role;Sampling;San Francisco;satisfaction;Schedule;screening;Screening procedure;screening program;secondary analysis;Sensory Deprivation;Shapes;Signal Transduction;skills;Societies;staff intervention;Surveys;theories;Time;tool;Training;translational potential;Translational Research;trial design;Universities;webinar;working group

PROJECT_TITLE: The Role of Hearing Loss in Health Care Outcomes

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Neurosciences;Opioids;Pain Research;Patient Safety

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The Hemodialysis Opioid Prescription (HOPE) Consortium will conduct a multicenter clinical trial evaluating treatment approaches to reduce pain and opioid use among people with kidney failure who are treated with maintenance hemodialysis. This research addresses a problem that is important to patients and the trial is expected to identify interventions that will ultimately improve how patients feel and function.

PI_NAMEs: DEMBER, LAURA M (contact);FARRAR, JOHN T;HSU, JESSE YENCHIH;KAMPMAN, KYLE MATTHEW

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Address;Agreement;Behavioral;Biometry;Buprenorphine;Chronic Kidney Insufficiency;chronic pain;chronic pelvic pain;clinical center;clinical epidemiology;Clinical Trials;Clinical Trials Data Monitoring Committees;Cognitive Therapy;Cohort Studies;Communities;Contracts;Data;data acquisition;Data Coordinating Center;data management;Data Reporting;design;Devices;Dialysis procedure;effectiveness evaluation;Electrolytes;electronic health data;Electronic Health Record;End stage renal failure;Exercise;experience;Funding;Hemodialysis;high standard;Human Resources;Hypertension;implementation intervention;improved;Individual;industry partner;Infrastructure;interdisciplinary approach;Intervention;intervention delivery;Intervention Trial;Kidney;Kidney Failure;Lead;Leadership;Maintenance;Manufacturer;medical schools;Mental disorders;Methodology;Monitor;mortality;Multi-Institutional Clinical Trial;Multicenter Studies;National Institute of Diabetes and Digestive and Kidney Diseases;Neurology;novel therapeutics;Opioid;opioid use;Outcome;Pain management;pain reduction;Participant;Patients;Pennsylvania;personalized medicine;Persons;pharmacologic;Pharmacologic Substance;Phenotype;Positioning Attribute;predicting response;Preparation;prescription opioid;Process;Protocols documentation;Provider;Psychiatry;psychosocial;quality assurance;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;recruit;Reporting;repository;Research;Research Personnel;Resources;Site;Specific qualifier value;Standardization;Time;tool;Training;trial design;Universities;uptake;urologic;Work;working group

PROJECT_TITLE: UPENN Scientific and Data Research Center for the HOPE Consortium to Reduce Pain and Opioid Use in Hemodialysis


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Clinical trials have become overly complex and expensive, resulting in major gaps in the availability of and knowledge about medical products. The Clinical Trials Transformation Initiative (CTTI), a public-private partnership co-founded by the FDA and Duke University, and involving all interested parties across the clinical trials ecosystem, develops and drives the adoption of recommendations and resources to improve the quality and efficiency of clinical trials. Through the support of this cooperative agreement, Duke will host and support CTTI's work to shape better the clinical trials of the future.

PI_NAMEs: ALEXANDER, JOHN H (contact)

PROGRAM_OFFICER_NAME: MILLER, KRISTEN

PROJECT_TITLE: Increasing the Quality and Efficiency of Clinical Trials (U18)

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-T (13)]


NIH_SPENDING_CATS: Aging

ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

PHR: Project Narrative  Responses to metabolic and other stresses play critical roles in development, many diseases, and aging. This project investigates how specific defenses against reactive oxygen species (ROS), metabolic stress, and misfolded proteins are regulated so that they respond to stress and other signals appropriately, including how they influence protein oxidation to maintain cellular function, resist stress, and ensure longevity.

PI_NAMEs: BLACKWELL, T KEITH (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Address;Aging;Biological;biological adaptation to stress;Caenorhabditis elegans;Cell Physiology;Cells;crosslink;Defense Mechanisms;Development;Dimensions;Disease;Disulfides;Endoplasmic Reticulum;Ensure;extend lifespan;FRAP1 gene;Generations;Genetic;Growth;Heat shock proteins;Homeostasis;Impairment;insight;Intervention;Investigation;life span;Lipids;Longevity;Maps;Metabolic;Metabolic stress;misfolded protein;model organism;Modeling;Mutation;Names;National Institute of General Medical Sciences;Organism;Orthologous Gene;oxidation;Oxidation-Reduction;Play;Process;Protein Isoforms;Proteins;Reactive Oxygen Species;Regulation;Research;Resistance;response;Role;Signal Transduction;Stress;System;transcription factor;Work;Xenobiotics

PROJECT_TITLE: Signaling mechanisms that detect stress and maintain homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Food allergy (FA) to multiple foods is increasingly common and can cause serious illness and death in children  and adults. We will use innovative approaches for immune monitoring and data analysis of blood and GI  tissues to investigate factors responsible for FA, and to improve our ability to manipulate the immune system to  safely treat people with FAs. We will also try to develop rapid blood tests that can be used to tailor treatment  for each individual patient with FA to improve treatment safety and efficacy.

PI_NAMEs: GALLI, STEPHEN JOSEPH (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Accident and Emergency department;Adult;Adverse event;Adverse reactions;Aftercare;Allergens;Allergic Disease;allergic response;Allergy to peanuts;analytical method;Anaphylaxis;anti-IgE;Antibodies;Asthma;B-Lymphocytes;Basophils;Biopsy;Blood;Blood Cells;Blood Tests;Cessation of life;Child;Clinical;clinical predictors;Clonal Expansion;Data;Data Analyses;desensitization;Development;Diagnosis;Disease;Dose;effective therapy;Event;Exhibits;experience;Food;food allergen;food challenge;Food Hypersensitivity;Functional disorder;Genomics;Goals;High-Throughput DNA Sequencing;Hospitals;Human;Hypersensitivity;Immune;Immune response;Immune system;Immunologic Monitoring;Immunophenotyping;Immunotherapy;improved;Individual;individual patient;individualized medicine;Ingestion;innovation;Interleukin 4 Receptor;Laboratories;Maintenance;Measurement;Measures;Methods;Monitor;multidisciplinary;Nature;novel strategies;Nuts;omalizumab;Oral;oral immunotherapy;Participant;patient response;Patients;peripheral blood;Persons;Phase;Phase II Clinical Trials;Phenotype;Pilot Projects;Placebo Control;Population;Prediction of Response to Therapy;predictive marker;Protocols documentation;Randomized;Regimen;Regulatory T-Lymphocyte;Research;Research Personnel;Resources;Risk;Safety;Sampling;Serology;Severities;Site;Specimen;success;Sum;Surveys;T-Lymphocyte;Testing;Tissues;Treatment Protocols;treatment response;Trees

PROJECT_TITLE: Integrated Genomic and Functional Studies of Immunotherapy for Multi-Food Allergy


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative This is a new U01 application to establish a Clinical Center (CC) for a prospective multiethnic HFpEF cohort from California central valley for multiscale novel deep phenotyping analyses. Our proposed study promises to contribute both technically and conceptually to the overall understanding of the molecular mechanisms underlying the heterogenous disease in HFpEF.

PI_NAMEs: CADEIRAS, MARTIN ;CHIAMVIMONVAT, NIPAVAN  (contact);LOPEZ, JAVIER ENRIQUE

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Age;aging population;aging related disease;Agriculture;Area;Atrial Fibrillation;biomedical referral center;Blood flow;California;Cardiovascular Diseases;Cardiovascular system;career development;Catchment Area;Center for Translational Science Activities;Chronic Kidney Failure;Classification;Clinic;Clinical;clinical center;Clinical Research;Clinical Sciences;cohort;college;community clinic;Community Hospitals;comorbidity;Complex;connectome;Coronary Arteriosclerosis;Country;Coupled;Data;Data Science;Data Set;Development;Diabetes Mellitus;Disease;EFRAC;electronic data;Electronic Health Record;Engineering;Enrollment;Environmental Science;Event;functional status;Funding;Genomics;Growth;Health Technology;Heart;Heart failure;heart failure with reduced ejection fraction;Heterogeneity;Hypertension;Image;Incidence;indexing;Inflammation;Inflammatory;innovation;insight;Latino;Latino Population;Learning;Machine Learning;medical schools;Metabolic;Metabolic syndrome;metabolomics;mHealth;microbiome;Mining;minority communities;Molecular;Molecular Analysis;molecular targeted therapies;Morbidity - disease rate;mortality;multi-ethnic;multidisciplinary;multiple omics;next generation;novel;Obesity;Organ;Participant;participant enrollment;patient engagement;patient population;Patients;Phase;phenomics;Phenotype;phrases;Plug-in;Population;Population Heterogeneity;Positron-Emission Tomography;preservation;programs;Progressive Disease;prospective;Proteomics;protocol development;Pulmonary Hypertension;Quality of life;Records;recruit;remote monitoring;Research;Research Institute;Research Personnel;Role;sex;skill acquisition;Source;Syndrome;Testing;Text;text searching;Therapeutic;United States;United States National Institutes of Health;Variant;web portal

PROJECT_TITLE: A prospective multiethnic HFpEF cohort from California's Central Valley


NIH_SPENDING_CATS: Clinical Research

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Contact PD/PI: Fawzi, Wafaie W Project Narrative The HBNU Fogarty Global Health Training Program, a consortium of Harvard University, Boston University, Northwestern University and the University of New Mexico, proposes to continue to contribute to global health research capacity building and the use of research to improve the health outcomes related to priority health areas in low- and middle-income countries (LMICs) in partnership with 18 sites throughout Africa, Asia, and South America. The Program will recruit US and LMIC trainees to strengthen global health research networks and programs at academic institutions and ultimately help sustain global health research in the US and LMICs. Project Narrative Page 8

PI_NAMEs: FAWZI, WAFAIE W (contact);HAMER, DAVIDSON HOWES;HAWKINS, CLAUDIA A;PERKINS, DOUGLAS JAY

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: Award;Biomedical Research;Boston;Cardiovascular Diseases;career;co-infection;Collaborations;Competence;Creativeness;Diabetes Mellitus;Discipline;Disease;E-learning;Education;Evaluation;experience;Fostering;Future;Future Generations;global health;HIV/AIDS;Individual;Institution;Interdisciplinary Study;International;Investments;low and middle-income countries;Malignant Neoplasms;Maternal and Child Health;medical schools;member;Mental Health;Mentors;Morbidity - disease rate;mortality;New Mexico;next generation;nutrition;Output;Peer Review;Persons;Postdoctoral Fellow;pre-doctoral;Principal Investigator;programs;Public Health Schools;Publications;Qualifying;Readiness;recruit;Research;research and development;Research Design;Research Methodology;Research Project Grants;Research Support;Research Training;Scientist;Site;Students;symposium;tool;Training;Training Programs;Underrepresented Populations;United States National Institutes of Health;Universities

PROJECT_TITLE: Launching Future Leaders in Global Health (LAUNCH) Research Training Program - Supplement for ORWH


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: ADVANCED IMAGING RESEARCH, INC.

PHR: NIH SBIR Fast-Track, PAS-22-196 Advanced Comprehensive Magnetic Resonance Solution for the Non Invasive Characterization of No Clinical Trials High Resolution Metabolic Biomarkers of Risk in Patients with Alzheimer’s Disease and Dementia Project Narrative  We propose to develop ADRD360, an advanced hardware-software package to optimally acquire, process, and analyze magnetic resonance (MR) imaging and spectroscopy in the human brain. Using ADRD360, we will localize metabolic signatures at much higher resolutions than currently possible on clinical MR systems. Although we propose testing these metabolic signatures as predictive biomarkers of the risk of developing Alzheimer’s Disease (AD) in this project, we believe the ADRD360 can improve brain assessment in patients with other neurological disorders. Confidential Proprietary Information Advanced Imaging Research dba SREE Medical Systems

PI_NAMEs: SRINIVASAN, RAVI  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: 3-Dimensional;absorption;Address;Age;Aging;Agreement;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Atrophic;Binding;Bioenergetics;Biological Markers;Brain;Calibration;Clinical;clinical application;Clinical Trials;commercialization;Computer software;Custom;Data;data acquisition;Dementia;design;detector;Development;Devices;diagnostic tool;Dimensions;Disease Progression;Early Diagnosis;Elderly;Energy Metabolism;Exhibits;Functional Magnetic Resonance Imaging;Goals;Head;high risk;Human;Image;improved;innovation;Licensing;Link;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Marketing;Measurable;Measurement;medial temporal lobe;Medical;medical schools;memory process;Mental disorders;Metabolic;metabolomics;Metric System;mild cognitive impairment;Minor;Mitochondria;National Institute on Aging;Nervous System Disorder;Nicotinamide adenine dinucleotide;Noise;novel;Nuclear;Patients;Pennsylvania;Performance;Phase;Play;predictive marker;Procedures;Process;programs;Protocols documentation;quality assurance;radio frequency;Reproducibility;Research;Research Personnel;Resolution;Risk;risk prediction;Satiation;Scanning;screening;Signal Transduction;Small Business Innovation Research Grant;software development;spectrograph;Spectrum Analysis;Structure;Symptoms;System;Technology;Testing;Time;Tissues;Training;transmission process;United States National Institutes of Health;Universities;Validation;Vendor;Visualization;Work

PROJECT_TITLE: ADVANCED COMPREHENSIVE MAGNETIC RESONANCE SOLUTION FOR THE NONINVASIVE CHARACTERIZATION OF HIGH RESOLUTION METABOLIC BIOMARKERS OF RISK IN PATIENTS WITH ALZHEIMER'S DISEASE AND DEMENTIA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PI_NAMEs: BOYCE, SABRINA CHRISTINE (contact)

PROJECT_TITLE: CE20-001 Evaluating Practice-based Programs, Policies, and Practices from CDCs Rape Prevention and Education (RPE) Program: Expanding the Evidence to Prevent Sexual Violence - 2020


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Gene Therapy;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: PROJECT NARRATIVE Human oral cancer caused by the human papillomavirus (HPV) is increasing dramatically and current treatment options are highly destructive and burdensome, leading to lower quality of life. We have identified a peptide that can more effectively carry small interfering RNA (siRNA) into these cancerous cells, which is a promising therapeutic alternative to the current standard of care. This study will establish the mechanism of how this peptide carrier works and give insight into additional modifications to make it even more effective.

PI_NAMEs: HOLJENCIN, CHARLES EVERETT (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Address;Amino Acids;Apoptosis;Bacteria;Binding;Biological Assay;Biology;Cancer Biology;cancer cell;Cancer Etiology;cancer therapy;Cancerous;Cell Line;Cell Nucleus;Cell Proliferation;Cell Survival;Cells;Cervical;Characteristics;chemical synthesis;chemotherapy;Clinical;Co-Immunoprecipitations;Complex;Data;delivery vehicle;design;Development;Disease;Disseminated Malignant Neoplasm;Drug Delivery Systems;Endocytosis;Excision;exosome;Fellowship;Filopodia;Fluorescence Microscopy;Fostering;Future;Gene Silencing;Generations;Genome;Head and Neck Squamous Cell Carcinoma;Heparan Sulfate Proteoglycan;HPV positive;Human;Human Papillomavirus;Impairment;improved;In Vitro;Incidence;Induction of Apoptosis;inhibitor;insight;Investigation;knock-down;Knock-out;Knowledge;Label;Laboratories;Lipofectamine;malignant mouth neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Messenger RNA;Methods;MicroRNAs;microscopic imaging;Mitochondrial DNA;Modification;Molecular;Morbidity - disease rate;nanocarrier;novel;nucleic acid delivery;nucleic acid-based therapeutics;Nucleic Acids;Oncogenes;Oncogenic;Oncolytic;Oncoproteins;Operative Surgical Procedures;Oral health;oral HPV-positive head and neck cancers;Outcome;overexpression;Pattern;Peptides;Production;Property;Quality of life;Radiation therapy;receptor;Receptor Cell;Reporting;Research;Retinoblastoma Protein;retrograde transport;RNA Interference;RNA Interference Therapy;RNA-targeting therapy;Role;Scientist;Series;siRNA delivery;Small Interfering RNA;Specificity;Stains;standard of care;System;Technology;Testing;Therapeutic;therapeutic gene;therapeutic siRNA;tool;Toxic effect;TP53 gene;Training;Treatment Efficacy;Tumor Suppressor Proteins;University of Pittsburgh Cancer Institute;uptake;Variant;Viral;Viral Oncogene;Virus;Work

PROJECT_TITLE: An investigation of how filopodia can be exploited by peptide carriers for enhanced uptake of RNAi cargo for the treatment of HPV+ oral cancers.