NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Nutrition;Prevention;Primary Health Care;Social Determinants of Health

PHR: Diet, other health behaviors, and social determinants of health, such as food insecurity, are difficult to change but are critical factors in the development and management of cardiometabolic disease. The proposed research will support Dr. Thorndike’s mentorship and research in developing novel strategies to improve dietary intake and other health behaviors in populations at risk for food insecurity and other social determinants of health. The research leverages Dr. Thorndike’s NIH-funded cohort of over 1,000 community health center patients and an existing Massachusetts General Hospital community health worker program to develop and test a community health worker nutrition intervention to improve dietary intake and blood pressure management in adult patients with hypertension and food insecurity.

PI_NAMEs: THORNDIKE, ANNE N (contact)

PROGRAM_OFFICER_NAME: ILIAS, MALIHA R

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;adverse outcome;Appointment;Architecture;Award;Behavior;Behavior Therapy;Behavioral;Beverages;Blood Pressure;blood pressure control;Body mass index;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardiovascular health;cardiovascular risk factor;career;career development;Chronic;Chronic Disease;cohort;Collaborations;Communities;Community Developments;Community Health Aides;community setting;Consumption;Data;Dedications;design;Development;Diet;Diet Modification;dietary;Dietary intake;Dietary Intervention;Disease;disease disparity;dissemination research;Education;Effectiveness;Effectiveness of Interventions;experience;Faculty;Food;food insecurity;Food Labeling;food resource;food security;Frontline worker;Funding;Future;General Hospitals;General Practices;Goals;Health;Health behavior;health care availability;health care service utilization;Health Food;Healthcare;High Prevalence;high risk;Home;Hypertension;hypertension control;implementation intervention;implementation research;improved;improved outcome;Individual;Infrastructure;interest;Internist;Intervention;Interview;Knowledge;Label;Life Style;Light;Longitudinal cohort;Low income;Low Income Population;marginalized population;Massachusetts;Medical;medical schools;medication compliance;Medicine;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Monitor;Neighborhood Health Center;novel;novel strategies;nutrition;nutrition education;Nutritional;Outcome;Paper;Participant;participant enrollment;patient engagement;patient oriented;patient oriented research;Patients;Personal Satisfaction;Pharmaceutical Preparations;Pilot Projects;pilot test;Policies;Populations at Risk;Postdoctoral Fellow;prevent;Prevention;Primary Care;primary care patient;primary outcome;Process;programs;psychologic;Public Health;Publications;Randomized;Research;Research Personnel;Research Support;Resources;secondary outcome;Security;Sleep;social;social determinants;social factors;social health determinants;socioeconomic disparity;Socioeconomic Factors;socioeconomics;Students;Supermarket;Surveys;Testing;Time;Training;Unhealthy Diet;United States National Institutes of Health;Visit;Workplace;Writing

PROJECT_TITLE: Mentorship in patient-oriented research on behavioral and social determinants of cardiometabolic health

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PI_NAMEs: WESTLER, WILLIAM MILO (contact)

PROJECT_TERMS: Address;Adoption;Algorithms;Area;base;Biomedical Research;Caring;Chad;cloud based;Code;Collaborations;commercialization;Common Data Element;Communities;community engagement;Computer software;computerized data processing;Connecticut;cost;Custom;Data;data acquisition;Data Collection;Deposition;design;Development;Disease;Educational workshop;Engineering;Ensure;experience;Faculty;feeding;Goals;Health Sciences;Instruction;instrumentation;Journals;Leadership;Manuals;meetings;Membrane;Membrane Proteins;Methods;new technology;Operating System;outreach;Peer Review;Persons;Physiologic pulse;Plug-in;Preparation;Protocols documentation;Publishing;Recording of previous events;Recruitment Activity;Reporting;Research;Research Personnel;Sampling;Services;Site;solid state nuclear magnetic resonance;Source Code;statistics;Structure;success;System;Technology;technology development;technology training;tool;Training;Universities;Update;Vendor;virtual machine;Visualization software;web portal;web server;web site

PROJECT_TITLE: Community Engagement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_CITY: KANSAS CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Protein translation is one of the most complex biological processes and maintaining fidelity during protein translation plays an important role during stress response and environmental adaptation in bacteria. The major goal of this project is to understand at the molecular level how some highly conserved novel accessory proteins are involved in translational fidelity in oral streptococci. This study will broaden our overall understanding on the molecular mechanisms of protein translation in streptococci and related organisms.

PI_NAMEs: BISWAS, INDRANIL  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Affect;Amino Acids;Amino Acyl Transfer RNA;Amino Acyl-tRNA Synthetases;antibiotic tolerance;Antibiotics;Anticodon;Bacteria;Biochemical;Biogenesis;Biological;biological adaptation to stress;Biological Assay;Biological Process;Cell Physiology;Cells;Codon Nucleotides;Complex;Data;Defect;Ensure;Environment;environmental adaptation;Escherichia coli;Exposure to;factor EF-P;Firmicutes;fitness;Genes;Genetic study;Genetic Transcription;genome wide screen;Genus Mycobacterium;Goals;Gram-Positive Bacteria;Growth;Heterogeneity;Hibernation;Homeostasis;Hypothetical Protein;In Vitro;in vivo;Life Style;Link;macromolecule;Messenger RNA;microbial;Microbial Biofilms;Molecular;novel;Nutrient;Nutritional;Oral cavity;oral pathogen;oral streptococci;Organism;Oxidative Stress;pathogen;Pathogenesis;Pathogenicity;Physiology;Play;Process;Production;Prokaryotic Cells;Protein Biosynthesis;protein function;Proteins;Proteome;Recycling;Replication Error;Resistance;Ribonucleoproteins;Ribosomal Proteins;Ribosomes;RNA;RNA, Ribosomal, 16S;Role;Series;stoichiometry;Streptococcus;Streptococcus mutans;Streptococcus pneumoniae;Streptococcus pyogenes;Stress;stress tolerance;Tertiary Protein Structure;trait;translation assay;Translation Process Protein;Translations;Virulence;Virulence Factors;Work

PROJECT_TITLE: Role of translational fidelity in cellular physiology of oral streptococci

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

ORG_STATE: NY

PHR: Project Narrative Sensitive periods during development govern circuit refinement in sensory cortices but it is unclear whether they also govern maturation of associative cortical areas such as the prefrontal cortex. Studying prefrontal circuit maturation is important for understanding psychiatric disorders with neurodevelopmental origin and altered prefrontal cortex function.

PI_NAMEs: KELLENDONK, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Amygdaloid structure;Anatomy;Area;ARHGEF5 gene;Attention;Behavior;cell type;Cognition;cognitive ability;Cognitive deficits;Corpus striatum structure;Data;density;Development;Disease;early adolescence;Etiology;imaging study;Impairment;improved;in vivo;Interneurons;Intervention;Link;Measures;Mental disorders;Mus;Neurobehavioral Manifestations;Neurodevelopmental Disorder;Neurons;Onset of illness;Outcome;Performance;Physiological;Physiology;postnatal;Prefrontal Cortex;Property;Protocols documentation;Rest;Schizophrenia;sensory cortex;Slice;Thalamic Nuclei;Thalamic structure;Time;Training

PROJECT_TITLE: Thalamo-prefrontal circuit maturation during adolescence

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: BOSTON

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: NARRATIVE The proposed research is relevant to public health, because technology development to discover regulatory mechanisms in transcription and mRNA processing is ultimately expected to significantly impact our understanding of most human disease. As such, the proposed research is relevant to the part of the NIH’s mission that seeks to develop fundamental knowledge and novel technologies to inform our diagnosis and treatment of human disease.

PI_NAMEs: CHURCHMAN, LEE STIRLING (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Adenine;base;base editor;Binding;Binding Proteins;Biochemical;biological adaptation to stress;blind;Cell Line;Cell Nucleus;Cells;Chromatin;Chromatin Fiber;Complex;Couples;Cytoplasm;Data;Data Set;design;Detection;Diagnosis;Disease;DNA;Down-Regulation;Elements;Enhancers;epigenomics;Event;Fiber;functional genomics;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;genomic data;Genomics;Heat-Shock Response;histone modification;human disease;Human Genome;Introns;Kinetics;Knowledge;Label;Location;Malignant Neoplasms;Maps;Measures;Messenger RNA;Metabolic;Methods;Methylation;Methyltransferase;Mission;Modeling;Molecular;Monitor;mRNA Precursor;nano;new technology;novel strategies;Nuclear;Nuclear Export;nucleobase;Nucleoplasm;Nucleosomes;Nucleotides;Play;Polymerase;Positioning Attribute;Precision Run-On Sequencing;premature;Process;Production;promoter;Promoter Regions;Public Health;recruit;Research;Residencies;Resolution;RNA;RNA chemical synthesis;RNA Editing;RNA Polymerase II;RNA Processing;RNA purification;RNA Splicing;RNA-Binding Proteins;Role;Shapes;Site;Techniques;Technology;technology development;termination factor;Testing;Third Generation Sequencing;Time;tool;Transcript;Transcription Elongation;transcription factor;Transcription Initiation;Transcriptional Regulation;transcriptome;transcriptome sequencing;U1 Small Nuclear Ribonucleoprotein;United States National Institutes of Health;Work

PROJECT_TITLE: Mechanisms of Transcriptional Control Revealed by Nascent Transcript Sequencing

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PI_NAMEs: BAKER, SHARYN D (contact)

PROJECT_TERMS: Abbreviations;Accounting;Acute Myelocytic Leukemia;Advisory Committees;animal imaging;anti-cancer research;Area;Award;Basic Science;Bioinformatics;biomedical informatics;Biomedical Research;Biometry;Budgets;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;cancer research center director;Cancer Survivorship;Carcinogenesis Mechanism;Chemoprevention;Clinical Cancer Center;Clinical Sciences;clinical translation;Clinical Treatment;Clinical Trials;college;Comparative Pathology;Complex;Comprehensive Cancer Center;cost effective;cost effectiveness;Cryoelectron Microscopy;digital imaging;Disease;Doctor of Pharmacy;Doctor of Philosophy;drug development;Drug Kinetics;Engineering;Ensure;Evaluation;exosome;Faculty;Faculty Recruitment;Flow Cytometry;Funding;Future;Genes;Genetically Engineered Mouse;Genomics;Goals;Grant;Growth;Image;Immunologic Monitoring;Immunooncology;Institution;instrumentation;Intervention;Intervention Studies;Intramural Research Program;Investments;Laboratories;leukemia;leukemia tissue bank;Libraries;Malignant Neoplasms;Medicine;member;Methods;Microscopy;Molecular Carcinogenesis;Monitor;mouse model;National Cancer Institute;NCI Center for Cancer Research;new technology;Nutrient;Ohio;Oncology;operation;pathology imaging;Pediatric Hospitals;Peer Review;Pharmaceutical Chemistry;Pharmacy facility;Phytochemical;Policies;Population Sciences;pre-clinical;Productivity;programs;Proteomics;Quality Control;recruit;Reporting;Research;Research Personnel;Research Priority;Resource Development;Resource Sharing;satisfaction;screening;Services;Slide;small molecule;Smoking;Speed;Surveys;System;Technology;translational genomics;Translational Research;translational therapeutics;United States National Institutes of Health;Universities;Validation;Vision;Visit;Work;working group

PROJECT_TITLE: Shared Resource Management

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: AUGUSTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Although tremendous advance in the research and clinical practice has been made over the past decade, heart disease is still a major cause of hospitalization and death worldwide. This study will address whether a novel protein post-translational modification is important to maintain heart function and investigate how dysfunction of this protein modification leads to dilated cardiomyopathy. This research will help advance our understanding of this debilitating disease; which could lead to new interventions.

PI_NAMEs: LI, JIE  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Ablation;Aging;Animals;attenuation;base;Binding;Binding Proteins;Biochemical;biological adaptation to stress;Biological Process;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;cell injury;Cell Physiology;Cessation of life;clinical practice;combat;Data;Development;Dilated Cardiomyopathy;Dimerization;Disease;Embryo;Embryonic Development;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;Event;Fibroblasts;Foundations;Functional disorder;Genetic Polymorphism;Genetically Engineered Mouse;Goals;Heart;Heart Diseases;Heart failure;heart function;Hematopoiesis;hemodynamics;Homeostasis;Hospitalization;Human;human disease;in vivo;Intervention;intestinal homeostasis;Knowledge;Ligase;loss of function mutation;Mediating;Modeling;Modification;Molecular;Molecular Target;Mus;Myocardial dysfunction;neuron development;novel;Pathogenesis;Pathogenicity;Pathologic;pharmacologic;Physiological;Pilot Projects;Post-Translational Protein Processing;pressure;prevent;Proteins;Publishing;Regulation;Reporting;Repression;Research;response;Rest;restoration;RNA Splicing;Role;Signal Transduction;Stress;Stress Response Signaling;Testing;therapeutically effective;Time;tool;transcriptomics;Transducers;Ubiquitin;Ubiquitin Like Proteins;Ubiquitination;Wrestling;XBP1 gene

PROJECT_TITLE: Wrestling stress: role of ufm1 modification in pathological cardiac remodeling

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This proposal will identify the circuit mechanisms responsible for generating large-scale networks in the early cortex, providing insights central to understanding how alterations in early network formation impact later sensory perception. In addition, these insights will be relevant for addressing the numerous neurodevelopmental disorders with abnormal sensory processing, such as autism and schizophrenia, as well as the broader range of neurological and psychiatric disorders involving abnormal functioning of cortical networks.

PI_NAMEs: SMITH, GORDON BRAWN (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Anatomy;Architecture;Area;autism spectrum disorder;Birth;Calcium;Computer Models;Development;Elements;Event;excitatory neuron;experimental study;Eye;Ferrets;Functional Imaging;Future;Image;Individual;inhibitory neuron;insight;Investigation;Knowledge;Label;Link;Measures;Mediating;Mental disorders;millimeter;Nervous System Disorder;neural;Neurodevelopmental Disorder;Neurons;novel;Optical Methods;Optics;optogenetics;orientation selectivity;Pattern;Perception;pharmacologic;Population;Positioning Attribute;predictive modeling;Primates;Publishing;recruit;Research;Schizophrenia;Sensory;serial imaging;Shapes;Stimulus;Structure;Surface;System;Testing;two-photon;Viral;Visual;Visual Cortex;Visual evoked cortical potential;Work

PROJECT_TITLE: Mechanisms governing development of large-scale networks in visual cortex

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


PI_NAMEs: POLLOCK, RAPHAEL E. (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;anti-cancer research;arm;Basic Science;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer education;Cancer health equity;cancer prevention;cancer research center director;Cancer Survivorship;career development;Catchment Area;Clinic;Clinical;clinical care;Clinical Research;Clinical Trials;Collaborations;college;Communication;Communities;community advisory board;community engagement;Community Outreach;community research;Comprehensive Cancer Center;Consultations;Data;Decision Making;Development;Disparity;Doctor of Pharmacy;Doctor of Philosophy;drug development;Education;Engineering;Ensure;Evaluation;experience;Faculty Recruitment;Fostering;Foundations;Funding;Funding Mechanisms;Future;Goals;Health;Height;Immunooncology;improved;Infrastructure;innovation;Institution;inter-institutional;Intramural Research Program;Lead;Leadership;life span;Malignant Neoplasms;meetings;member;Mentors;Mission;NCI Center for Cancer Research;NCI-Designated Cancer Center;Ohio;operation;outreach;Persons;Policies;Population;Population Research;Population Sciences;Prevention;Process;programs;recruit;Reporting;Research;Research Priority;Research Support;Resource Sharing;Resources;Review Committee;Science;Scientific Advances and Accomplishments;Strategic Planning;success;survivorship;Time;Training and Education;training opportunity;translational genomics;Translational Research;Universities;Update;Vision;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunotherapy;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative  CAR T-cells have revolutionized the treatment of blood cancers, but 50% of responsive patients eventually relapse and in ~50-70% of patients, this therapy induces devastating side effects (i.e. neurotoxicity (NTX) and cytokine release syndrome (CRS)). By studying the pre-monocytic activation status and cytokine profiles from the monocyte fraction of a patient, this proposal will aim to validate that one can predict CAR T toxicity and efficacy. Through the use of a developed humanized mouse model we will investigate if this pre- inflammatory status is causative of toxicity outcomes.

PI_NAMEs: GUSTAFSON, HEATHER LEIGH HERD (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Adopted;Antigens;Antitumor Response;Automobile Driving;Biological Markers;Biology;biomarker validation;Blood;blood treatment;blood-brain barrier crossing;Body Weight decreased;CAR T cell therapy;CD14 gene;CD19 gene;CD22 gene;Cell Physiology;Cell-Mediated Cytolysis;Cells;Cellular immunotherapy;Cessation of life;Characteristics;Child;Childhood;Childhood Hematopoietic Neoplasm;Childhood Leukemia;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical biomarkers;clinical predictors;Clinical Trials;cohort;Collaborations;Coupled;cytokine;cytokine release syndrome;Cytokine Signaling;Dangerousness;Data;Development;Disease;Dose;Engineering;Engraftment;Etiology;Excision;experience;experimental study;Functional disorder;Genetic Predisposition to Disease;Genetic Transcription;Grant;Hematopoietic Neoplasms;Hemophagocytic Lymphohistiocytoses;HIF1A gene;Histology;Human;humanized mouse;IL18 gene;Immune;Immune system;Immunity;Immunotherapy;improved;improved outcome;In Vitro;Individual;Inflammatory;insight;Interferon Type II;Interferons;Interleukin-10;Interleukin-12;interleukin-18 receptor;Investments;Kinetics;KLRB1 gene;leukemia;Life;Machine Learning;machine learning algorithm;Measures;Mediating;Medical;monocyte;mouse model;Myelogenous;Myeloproliferative disease;Nervous System Trauma;Neuroblastoma;neurotoxicity;novel;Outcome;patient population;patient response;patient subsets;Patients;Pediatric Neoplasm;pediatric patients;Peripheral Blood Mononuclear Cell;Phenotype;Play;Population;predicting response;predictive marker;Production;programs;Recording of previous events;Recurrence;Relapse;Research;Resources;response;Risk;Role;Safety;Sampling;Series;Serum;side effect;Signal Transduction;Solid Neoplasm;success;survival prediction;T-Lymphocyte;The Jackson Laboratory;Therapeutic;Time;Toxic effect;trafficking;Treatment-related toxicity;trend;trial design;tumor;Tumor Biology;Work

PROJECT_TITLE: The IL-18-IFNγ axis predicts response to immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative (Public Health Relevance Statement) Formaldehyde is a major environmental toxin and carcinogen whose aberrant exposure is connected to diseases spanning liver and cardiovascular disorders, cancer, diabetes, and neurodegeneration, but at the same time the body continually produces this reactive carbonyl species during normal physiology. We are developing and applying new chemical reagents for selective imaging and proteomics of formaldehyde in living systems to identify its molecular sources and targets, with the long-term goal of understanding how this reactive small molecule contributes both to normal physiology and disease.

PI_NAMEs: CHANG, CHRISTOPHER J. (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TITLE: Chemical Probes to Study Formaldehyde Biology

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Mental Health;Neurosciences;Rehabilitation

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: NARRATIVE This project will create a novel serial optical coherence scanner system that can image axonal tracts within the brain at micrometer spatial resolution using unbiased label-free optical contrasts. This approach will bridge macroscale, mesoscale, and microscale brain connectivity to create a platform that can be used for future human connectome studies at the micron scale across the entire human brain.

PI_NAMEs: AKKIN, TANER  (contact);HEILBRONNER, SARAH RACHEL

PROGRAM_OFFICER_NAME: ALVAREZ, RUBEN PAUL

PROJECT_TERMS: 3-Dimensional;Algorithms;analytical tool;Anatomy;Animal Model;Architecture;Atlases;attenuation;Axon;Birefringence;Brain;brain circuitry;Brain Diseases;Brain imaging;Brain Mapping;brain tissue;Cells;cingulate cortex;connectome;Deep Brain Stimulation;density;Development;Diffusion Magnetic Resonance Imaging;Disease;Dissection;Electroencephalography;Electron Microscopy;Face;Fascicle;Fiber;Foundations;Functional Magnetic Resonance Imaging;Future;Generations;Goals;gray matter;Histologic;Human;human imaging;Image;image processing;imaging modality;Imaging technology;improved;in vivo;Injections;Internal Capsule;Label;Lasers;Lateral;Location;Macaca mulatta;Maps;Mental disorders;meter;Methods;Microscopic;Motor;Motor Cortex;multiparametric imaging;nanoscale;Nervous System Disorder;neural tract;neuroimaging;Neurons;neurosurgery;nonhuman primate;novel;Optical Coherence Tomography;optical imaging;Optics;Pathway interactions;Pattern;Performance;Phase;polarized light;Population;quantitative imaging;Rattus;reconstruction;Resolution;Sampling;Structure;Structure of subthalamic nucleus;Synapses;System;targeted treatment;Techniques;Technology;Thalamic structure;Tissues;Tracer;tractography;Visible Radiation;Visualization;white matter;Work

PROJECT_TITLE: Label-free optical imaging for human mesoscale connectivity with a focus on deep brain stimulation targets


NIH_SPENDING_CATS: Aging;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: HAYS, JOHN L. (contact)

PROJECT_TERMS: Adherence;Adolescent and Young Adult;Age;aging population;anti-cancer research;Area;arm;Cancer Center Support Grant;cancer clinical trial;cancer diagnosis;Cancer health equity;Cancer Patient;cancer research center director;Cancer Research Project;Cancer Therapy Evaluation Program;Catchment Area;Censuses;Cessation of life;Charge;Child;Childhood;Clinical;Clinical Cancer Center;Clinical Data;Clinical Investigator;Clinical Management;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Network;Communities;Community Outreach;Comprehensive Cancer Center;Conduct Clinical Trials;cost effective;Data;data management;Dedications;Diagnosis;Disease;Doctor of Philosophy;Effectiveness;Ensure;Female;Goals;Good Clinical Practice;Grant;Guidelines;Hispanic;Hispanic Populations;improved;Individual;Infrastructure;Intervention;Intervention Studies;Investigational Therapies;investigator training;investigator-initiated trial;Leadership;life span;Maintenance;Malignant Neoplasms;Measures;Methodology;Minority;Minority Enrollment;Mission;Monitor;multidisciplinary;Ohio;older adult;outreach;participant enrollment;patient safety;Patients;Pediatric Hospitals;Physician Executives;Physicians;Policies;Population;Population Heterogeneity;Population Sciences;programs;Protocol Compliance;Protocols documentation;Provider;quality assurance;Quality Control;racial minority;Reporting;Research;Research Activity;research clinical testing;Research Personnel;Resources;Safety;Scientist;Serious Adverse Event;Services;sound;Special Population;Strategic Planning;Therapeutic;Therapeutic Intervention;Time;timeline;Underserved Population;Universities;Vision;Woman

PROJECT_TITLE: Clinical Protocol and Data Management


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Obesity;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: Wheelchair users have a higher risk for obesity and cardiometabolic health-related diseases compared to persons without a disability and remain one of the most sedentary populations in the United States. Engaging wheelchair users in physical activity levels following the current recommendations to achieve cardiometabolic health-related changes requires tailoring and supports in an accessible community environment, but it is unclear if a community-based physical activity intervention that also prioritizes intensity levels is best to improve cardiometabolic health. This project will determine the effects and implementation outcomes of a community-based, intensity-controlled aerobic and strength training intervention on the cardiometabolic health of WU and will significantly advance public health knowledge of how to engage wheelchair users in physical activity to reverse or prevent cardiometabolic health-related disease.

PI_NAMEs: MORGAN, KERRI ANN (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: actigraphy;Address;Adult;Aerobic Exercise;Age;Blood Vessels;Body Composition;cardiometabolic risk;cardiometabolism;cardiorespiratory fitness;Cardiovascular Diseases;cardiovascular risk factor;Characteristics;Clinical Trials;Collaborations;Communities;community organizations;compare effectiveness;comparison intervention;Data;Diagnosis;disability;Disease;Education;Educational Intervention;Endothelium;Environment;Equipment;evidence base;Exercise;exercise intervention;experience;Face;Failure;Frequencies;Funding;Future;Gender;General Population;Goals;group intervention;Guidelines;Health;Health Benefit;health knowledge;high risk;Hybrids;implementation intervention;implementation outcomes;implementation science;improved;improved outcome;Individual;Intervention;intervention effect;Knowledge;Laboratories;Lived experience;Measures;Mediator;Metabolic;Modeling;moderate-to-vigorous physical activity;Monitor;Motivation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity risk;Outcome;Pain;Participant;participant interview;Persons;Physical activity;Physical Function;physically handicapped;Physiological;Population;Positioning Attribute;prevent;primary outcome;programs;Protocols documentation;Public Health;Race;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;response;Sample Size;Sampling;sedentary;Self Efficacy;strength training;Stroke;Structure;success;System;Testing;therapy design;Training Activity;Training Support;trial comparing;United States;vigorous intensity;wearable device;Wheelchair user;Wheelchairs;Work

PROJECT_TITLE: Wheelchair user physical activity training intervention to enhance cardiometabolic health (WATCH): A community-based randomized control trial


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness;Sleep Research

ORG_CITY: EUGENE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: 8. PROJECT NARRATIVE Adolescents experience a confluence of major risk factors for depression, including short sleep duration, late sleep timing, and exposure to stressful life events. This research will use biobehavioral approaches to generate understanding about the linkages between sleep duration and timing, stressful life events, and depressive symptoms in adolescents, with a long-term aim of developing effective preventative interventions.

PI_NAMEs: CASEMENT, MELYNDA D (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: 19 year old;Adolescence;Adolescent;Adult;Anhedonia;Behavioral;biobehavior;Biological Markers;Brain;Characteristics;circadian;Clinical;depression model;depression prevention;depressive symptoms;design;Development;Diagnosis;disability;Endocrine;Etiology;Event;experience;Experimental Designs;experimental study;Exposure to;Goals;Growth;high school;Hour;improved;improvement on sleep;Incidence;Intervention;Laboratories;Licensing;Life;Link;Measurement;Measures;Medial;Mediating;Mental Depression;Mental Health;Mental health promotion;Modeling;modifiable risk;Monitor;Morbidity - disease rate;mortality;National Institute of Mental Health;Observational Study;Participant;Patient Self-Report;Prefrontal Cortex;Prevalence;Prevention;preventive intervention;Psychologist;Psychopathology;Randomized;Recommendation;recruit;Recurrence;Reporting;Research;Research Design;Research Personnel;response;Rewards;Risk;Risk Factors;Sampling;Series;Severities;single episode major depressive disorder;Sleep;sleep behavior;Sleep Deprivation;Sleep disturbances;sleep regulation;Stress;Stressful Event;stressor;suicidal;Symptoms;System;Testing;Time;Translating;Work

PROJECT_TITLE: Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep Duration and Timing to Reward- and Stress-Related Brain Function

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: We propose to investigate how pancreas cells first start becoming neoplastic and how they progress to malignant cancer cells using a novel model system that we have developed and tested. Our studies will help us understand how pancreatic cancer starts and what signals initiate the process. The outcome from our project will enable future studies to develop more specific and effective treatments for this deadly disease.

PI_NAMEs: WANG, PEI  (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Acinar Cell;Binding;Biological Models;cancer cell;Cancer cell line;cancer initiation;Cancer Model;cancer therapy;Cell Lineage;Cell model;Cell Proliferation;Cells;Characteristics;Data;detection method;Development;diagnostic biomarker;Disease;Disparity;Duct (organ) structure;Ductal Epithelial Cell;Early Diagnosis;effective therapy;Epigenetic Process;Future;Gene Expression;Gene Expression Profile;Gene Modified;Genes;Genetic;genetic manipulation;Human;improved;In Vitro;innovation;insight;Investigation;Islets of Langerhans Transplantation;KRAS oncogenesis;KRAS2 gene;Lesion;MADH4 gene;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant phenotype;Mediating;Metaplasia;Methods;Modeling;Molecular;Morphologic artifacts;mouse model;Mucinous Neoplasm;Mus;mutant;Mutate;Mutation;Neoplasms;neoplastic;novel;Oncogenes;Organoids;Outcome;Outcome Study;Pancreas;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;Pancreatitis;Papillary;Pathogenesis;Pathway interactions;Patients;Play;premalignant;Process;prognosis biomarker;Prognostic Marker;Proliferating;promoter;Property;Role;Sampling;Signal Pathway;Signal Transduction;Stratification;Survival Rate;System;Testing;The Cancer Genome Atlas;Therapeutic;Tissues;TP53 gene;Transforming Growth Factor beta;transplant centers;transplant model;tumor;tumor progression;tumorigenesis

PROJECT_TITLE: Mechanisms of pancreatic cancer initiation and progression from normal human pancreatic tissue

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEWARK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because several neurodevelopmental, mental and neurodegenerative disorders, including autism spectrum disorders (ASD), schizophrenia and prodromal Alzheimer’s disease (AD), are associated to difficulties in processing sensory information that could result from an abnormal top-down control of sensory processing. As our goal in this project is to determine the function and mechanisms of top-down modulation of visual processing, it is relevant to the part of NEI mission that pertains to supporting research that advance our knowledge of how visual system functions in both health and disease.

PI_NAMEs: POLACK, PIERRE- OLIVIER  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Affect;Animals;area striata;Attention;Auditory;autism spectrum disorder;awake;Behavior;Behavioral;Calcium;Chemosensitization;Code;Complex;Comprehension;Cues;Data;Degenerative Disorder;developmental disease;Discrimination;discrimination task;Disease;Electrophysiology (science);Exposure to;extrastriate visual cortex;flexibility;Functional disorder;Functional Imaging;Genetic;Goals;Health;Image;Impairment;improved;innovation;Knowledge;Laboratories;Lateral Geniculate Body;Locomotion;Mental disorders;Mission;Modeling;multisensory;Mus;Nervous System Disorder;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;novel;Outcome;Perception;Physiological;Population;Primates;prodromal Alzheimer's disease;Property;Public Health;receptive field;Reporting;Research;Research Support;response;Role;Schizophrenia;Sensory;Shapes;Signal Transduction;skills;sound;Stimulus;Techniques;Testing;tool;Training;two-photon;V1 neuron;Visual;visual control;Visual Cortex;Visual Perception;visual processing;visual stimulus;Visual System;Weight;Whole-Cell Recordings

PROJECT_TITLE: Top-down modulation of visual processing: mechanisms and functions


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE Understanding the effect of DNA somatic alterations and perturbations is still an open problem in cancer research. This project aims to provide principled machine learning algorithms as a computational approach to achieve this understanding. The proposed aims will result in improved and potentially actionable knowledge/analyses from sequencing data from cancer patients, and an efficient and scalable framework that can be used for experimental design.

PI_NAMEs: STOJANOV, PETAR  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Affect;Algorithms;anti-cancer research;Appointment;Artificial Intelligence;Biomedical Research;cancer cell;Cancer Patient;career;career development;causal variant;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;combinatorial;Communities;Computational Technique;computer framework;computer science;Data;Data Set;design;Development;Disease;DNA;DNA Sequence Alteration;Doctor of Philosophy;driver mutation;Epigenetic Process;Etiology;exome;experience;Experimental Designs;experimental study;Family;follow-up;Gene Expression;gene function;Generations;generative models;Genes;genome sequencing;Germ Lines;Goals;Graph;Heterogeneity;heterogenous data;high dimensionality;Immune;improved;In Vitro;insight;interest;Knock-out;Knowledge;Learning;Link;Machine Learning;machine learning algorithm;Malignant Neoplasms;Measures;Methodology;Methods;Modeling;Modification;Mutation;Neighborhoods;next generation sequencing;Outcome;Patients;Pharmaceutical Preparations;Phenotype;Physicians;Positioning Attribute;Postdoctoral Fellow;Predisposition;Program Development;Property;Proteins;Protocols documentation;research and development;Resources;Scientist;Series;single-cell RNA sequencing;Stratosphere;Techniques;tenure track;Testing;therapeutic target;Tissues;tool;Training;tumor;Universities;Variant;whole genome;Work

PROJECT_TITLE: AI-Powered Uncovering of Mechanisms in Cancer Through Causal Discovery Analysis and Generative Modeling of Heterogeneous Data


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: RAMASWAMY, BHUVANESWARI  (contact)

PROJECT_TERMS: Amendment;Appropriateness Review;Area;Behavior Therapy;Businesses;Cancer Center Support Grant;Cancer Control;cancer prevention;Charge;Clinical;Clinical Cancer Center;Clinical Protocols;Clinical Trials;Committee Members;Communication;Comprehensive Cancer Center;Data;Disease;Drug Industry;Ensure;Exclusion Criteria;expectation;expedited review;Experimental Designs;Goals;Grant;inclusion criteria;Institution;Institutional Review Boards;Intervention;life span;Malignant Neoplasms;Medical Records;member;Monitor;NCI Center for Cancer Research;Ohio;Patients;Pediatrics;Peer Review;Pharmacists;Pharmacy facility;programs;Protocols documentation;Quality Control;Research;Research Personnel;Resources;Retrospective Studies;Review Committee;Safety;System;Time;treatment planning;Underserved Population;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dietary Supplements;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Sleep disturbances are reported by up to 45% of persons with Mild Cognitive Impairment (MCI) and Alzheimer’s disease and contribute to functional limitations, reductions in quality of life, and is a major driver of institutionalization. This project will examine whether Citicoline (a dietary choline supplement) can significantly increase choline levels and decrease inflammatory and potentially AD-associated biomarkers during a prodromal stage of AD (MCI due to AD). Positive outcomes from this project will enable better treatment of persons with MCI due to AD who are experiencing sleep disturbances in order to improve their health and well- being.

PI_NAMEs: PAK, VICTORIA M (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, BENFEARD LEECHELLE

PROJECT_TERMS: Acetylcholine;actigraphy;Age;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Animal Model;basal forebrain;Beds;Biological;Biological Markers;Caregivers;Cerebral cortex;Characteristics;Choline;cholinergic;cholinergic neuron;Cognition;cognitive function;cohort;Controlled Clinical Trials;Cytidine;Cytidine Diphosphate Choline;Data;Dementia;Development;Devices;dietary;Dietary Supplementation;Disease;Double-Blind Method;double-blind placebo controlled trial;Drowsiness;effective therapy;Episodic memory;experience;Female;fluorodeoxyglucose positron emission tomography;follow up assessment;follow-up;Health;high risk;hippocampal atrophy;Home;Impaired cognition;Impairment;improved;improvement on sleep;inclusion criteria;Individual;Inflammation;Inflammatory;Institutionalization;interest;Interleukin-6;Intervention;male;Measures;Mediator;Memory;men;mild cognitive impairment;National Institute on Aging;nerve supply;Neurobiology;neuroinflammation;neurotransmission;Neurotransmitters;older adult;oral supplementation;Outcome;Participant;Patient Recruitments;Patients;Performance;Personal Satisfaction;Persons;Phospholipids;Pilot Projects;Placebo Control;placebo group;Placebos;Plasma;Play;poor sleep;Population;Process;prodromal Alzheimer's disease;Production;Proteins;Quality of life;Questionnaires;Randomized;randomized, clinical trials;Regulation;REM Sleep;Reporting;Research;Research Personnel;Role;Sampling;secondary outcome;Sirtuins;Sleep;Sleep disturbances;sleep quality;Supplementation;System;tau Proteins;tau-1;Testing;therapeutic target;Threonine;Time;TNF gene;trial comparing;United States National Institutes of Health;Woman;Work;Wrist

PROJECT_TITLE: Improving Sleep and AD Biomarkers: A Pilot RCT of Citicoline


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: COOMBES, KEVIN ROBERT (contact)

PROJECT_TERMS: Abbreviations;Adverse event;Algorithms;animal imaging;anti-cancer research;Area;arm;biobank;Bioinformatics;Bioinformatics Shared Resource;biomedical informatics;Biometry;Budgets;Cancer Biology;cancer care;Cancer Center Support Grant;Cancer Control;Cancer Hospital;Chemoprevention;Clinical Data;clinical translation;Clinical Treatment;Clinical Trials;Comparative Pathology;Complex;Comprehensive Cancer Center;Computational Biology;Data;data analysis pipeline;data de-identification;data integration;data management;Data Set;Data Storage and Retrieval;data visualization;data warehouse;digital imaging;Dimensions;Disparate;DNA;drug sensitivity;Faculty;falls;Flow Cytometry;Fostering;Funding;Future;Gene Expression;Generations;GENIE;genomic data;Genomics;Genomics Shared Resource;Goals;Grant;Health protection;Immunologic Monitoring;Immunooncology;improved;Informatics;Information Technology;Institution;Institutional Review Boards;instrumentation;Intervention;Intramural Research Program;Leadership;Left;leukemia;leukemia tissue bank;Literature;Malignant Neoplasms;Medical center;member;metabolomics;Metagenomics;Microscopy;Molecular Carcinogenesis;Monitor;next generation sequencing;novel;Ohio;Oncology;Participant;pathology imaging;Patients;Pediatric Hospitals;Pharmaceutical Chemistry;Population Sciences;Process;programs;Proteomics;Protocols documentation;Publications;Records;recruit;Reporting;Research;Research Institute;Research Personnel;Resource Sharing;Safety;Services;single cell sequencing;Source;Surveys;System;technology platform;The Cancer Genome Atlas;tool;Translational Research;translational therapeutics;Universities;Untranslated RNA;Visual;Work

PROJECT_TITLE: Shared Resource 01: Biomedical Informatics (BISR)


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: PROVIDENCE

ORG_DEPT: PSYCHIATRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative The purpose of this study is to determine how often and how much adolescents and young adults with Autism Spectrum Disorders (ASD) use alcohol and other drugs. Approximately 400 adolescents and young adults with ASD will be assessed four times annually to determine overall rates of alcohol and other drug use, when and if persons with ASD start to use alcohol and other substances as well as if their use increases over time.

PI_NAMEs: JACKSON, KRISTINA MELIA;SHEINKOPF, STEPHEN J;SPIRITO, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Adolescence;Adolescent and Young Adult;adolescent with autism spectrum disorder;Affect;Age;alcohol and other drug;Alcohol consumption;alcohol risk;alcohol screening;alcohol use disorder;Anxiety Disorders;Assessment tool;Attention deficit hyperactivity disorder;autism spectrum disorder;Benchmarking;biological age;biological sex;brief prevention intervention;Clinical;clinical practice;Clinical Research;Cognitive;cohort;college;comorbidity;Data;Demographic Factors;Development;Diagnosis;Disease;drinking onset;Drug Prescriptions;Drug usage;Electronic Nicotine Delivery Systems;experience;Exposure to;Family;Family history of;Future;General Population;Health;Health Professional;high risk;high school;Independent Living;Individual;individuals with autism spectrum disorder;Informal Social Control;Interview;Language;Literature;male;Marijuana;marijuana use;Mental disorders;Mental Health;misuse of prescription only drugs;Monitor;normative education;parental monitoring;Parents;Participant;peer;Persons;Population;population based;Prevalence;protective factors;Psychiatric therapeutic procedure;psychoeducation;Registries;Reporting;Research;Rhode Island;Risk;Risk Factors;risk selection;Sampling;Scandinavian;social anxiety;Social Controls;Social Environment;Societies;Structure;Subgroup;substance use;Testing;Time;Tobacco;trend;vaping;verbal;virtual;young adult;young adult with autism spectrum disorder;Youth

PROJECT_TITLE: Prevalence, onset and progression of substance use in adolescents and young adults with Autism Spectrum Disorders


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Lung;Lung Cancer;Radiation Oncology

ORG_DEPT: SURGERY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative We will delineate novel mechanisms by which lung resident Scgb1a1+ club cell factors attenuate immunosuppressive signaling networks in myeloid cells to activate T cells resulting in a durable anti-tumor immunity in mouse models of NSCLC, and leverage samples from a neoadjuvant clinical trial of radiation therapy in combination with immune checkpoint inhibitor to determine if club cell- based biomarkers are associated with response and metastatic recurrence.

PI_NAMEs: ALTORKI, NASSER KHALED;MITTAL, VIVEK  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Acute;Aftercare;arm;Attenuated;Biological Markers;Biopsy;Cancer Patient;cancer type;cell killing;Cell Line;Cell secretion;Cells;checkpoint therapy;Clinical;Clinical Trials;Combined Modality Therapy;Cytotoxic T-Lymphocytes;Development;Dose;Effectiveness;effector T cell;experience;genetic signature;Human;immune checkpoint blockade;Immune checkpoint inhibitor;immune modulating agents;Immune system;immunoregulation;Immunosuppression;Immunotherapy;improved;Inflammation Mediators;Inflammatory;inhibitor;insight;Link;Lung;Malignant neoplasm of lung;Mediating;Mediator;Medical;member;Metastatic/Recurrent;molecular targeted therapies;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Natural Killer Cells;Neoadjuvant Therapy;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Operative Surgical Procedures;Outcome;Patients;PD-1 blockade;PD-1/PD-L1;Phenotype;Plasma;Plasma Cells;pre-clinical;preclinical trial;predicting response;prognostic;Proteomics;pulmonary function;Radiation therapy;Recurrence;Resected;Resistance;response;response biomarker;Role;Sampling;Secretory Cell;Signal Transduction;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Tissues;treatment response;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Work

PROJECT_TITLE: Immunoregulatory role of lung-resident club cell factors in lung cancer


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Prevention

PI_NAMEs: HAMPEL, HEATHER D (contact)

PROJECT_TERMS: Abbreviations;Accreditation;Address;American;analytical tool;animal imaging;Area;biobank;biomedical informatics;Biometry;Blood;Budgets;Cancer Biology;cancer care;Cancer Center Support Grant;Cancer Control;Cancer Hospital;Cancer Patient;cancer prevention;Cancer Survivorship;cancer therapy;Chemoprevention;Childhood;Clinical;Clinical Data;clinical translation;Clinical Treatment;Clinical Trials;college;Comparative Pathology;Comprehensive Cancer Center;Computerized Medical Record;Consent;Data;Diagnosis;digital imaging;Disease;Engineering;Enrollment;Equipment and supply inventories;exome sequencing;Faculty Recruitment;Flow Cytometry;Funding;Future;genomic data;Genomics;Goals;Grant;Health protection;Histology;Immunooncology;innovation;Institution;Institutional Review Boards;instrumentation;Intervention;Intramural Research Program;Laboratories;Leadership;leukemia;leukemia tissue bank;Malignant Neoplasms;Management Information Systems;material transfer agreement;member;Mentored Clinical Scientist Development Program;Microscopy;Minor;Mission;Molecular Carcinogenesis;new technology;next generation;Normal tissue morphology;Nutrient;Ohio;Oncology;Online Systems;Pathologist;Pathology;pathology imaging;Patients;Pediatric Hospitals;Pharmaceutical Chemistry;Phytochemical;Prevention;Procedures;programs;prospective;Proteomics;Protocols documentation;Publications;recruit;Research;Research Institute;Research Personnel;Resource Sharing;Sampling;Services;Specimen;Specimen Handling;square foot;Surveys;Tablets;Time;Tissue Procurements;Tissues;translational genomics;Translational Research;translational therapeutics;Tumor Tissue;Universities;Visualization software;Work

PROJECT_TITLE: Shared Resource 02: Biospecimen Services (BSSR)


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunotherapy;Lung;Lung Cancer;Precision Medicine

PHR: Project Narrative Using integrated pharmacological and genetic approaches, we will delineate novel immunosuppressive mechanisms elicited by endoplasmic reticulum sensor IRE1, determine if IRE1α inhibition sensitizes NSCLC to PARP inhibitors, STING agonists, and/or radiation therapy by enhancing type-I IFN responses, and assess the clinical relevance of IRE1 gene signatures in human NSCLC.

PI_NAMEs: CUBILLOS-RUIZ, JUAN R;MITTAL, VIVEK  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: antitumor effect;arm;Binding Proteins;biological adaptation to stress;Breast;cancer cell;Cancer Model;Cancer Patient;cancer type;checkpoint inhibition;Clinical;clinical translation;Clinical Trials;clinically relevant;Code;cohort;design;effective therapy;Endoplasmic Reticulum;endoplasmic reticulum stress;FDA approved;Free Radicals;Future;Genetic;genetic approach;genetic signature;Goals;Human;Hypoxia;Immune Evasion;immunoregulation;Immunosuppression;Immunotherapeutic agent;inhibitor;innovation;insight;Interferons;intervention effect;Lymphoid Cell;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;Messenger RNA;molecular targeted therapies;mortality;mouse model;multitask;Mus;Myeloid Cells;Neoplasm Metastasis;next generation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Nutrient;Outcome;outcome prediction;Ovarian;Pathway interactions;Patients;pharmacologic;Poly(ADP-ribose) Polymerase Inhibitor;Prediction of Response to Therapy;predictive signature;programs;protein folding;Protein Isoforms;Proteins;Radiation therapy;Repression;response;Ribonucleases;Role;sensor;Signal Transduction;Starvation;STING agonists;survival outcome;survival prediction;Testing;Therapeutic;therapeutic target;Time;transcription factor;transcriptome sequencing;translational potential;Treatment outcome;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;XBP1 gene

PROJECT_TITLE: ER stress-driven IRE1a-XBP1 signaling in lung cancer


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PUBLIC HEALTH RELEVANCE STATEMENT The proposed research is relevant to public health because it is known that cancer risk increases with age, and that genetic instability and epigenetic alterations (e.g., cytosine methylation) are hallmarks of both aging and cancer; yet the underlying mechanisms involved and to what extent they are associated are not clear. We have found that alternative DNA structures serve as endogenous mutation hotspots in human cancer genomes, and that DNA structure-indcued genetic instability is altered with age in a tissue-specific fashion and by cytosine methylation; thus, we will explore the underlying mechanisms involved to inform on the development of various types of cancer. Results from the proposed study are expected to have a significant positive impact by delineating the relationship between tissue-specific DNA structure-induced genetic instability and epigenetic modification- related non-B DNA formation and instability as a function of age, which will guide the long-term goal of developing new strategies to prevent and/or treat age-associated diseases, such as cancer.

PI_NAMEs: VASQUEZ, KAREN M (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Age;age effect;age related;age related changes;age-related disease;Aging;aging population;aging related;Brain;Cancer Etiology;cancer genome;cancer risk;cancer type;cell type;Chromatin;chromatin immunoprecipitation;Colon;Cytosine;Data;Development;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;DNA Sequence;DNA Structure;Epigenetic Process;Etiology;Funding;Future;Generations;Genetic;Genetic Induction;Genome;Goals;H-DNA;Human;improved;Incidence;Individual;Induced Mutation;innovation;Kidney;Knowledge;Link;Liver;Malignant Neoplasms;Mammals;Measures;Methylation;Mismatch Repair;Modification;Mus;Mutagenesis;Mutation;novel;Nucleotide Excision Repair;old mice;Outcome;Pathologic Mutagenesis;prevent;Property;Proteins;Proteomics;Public Health;public health relevance;Publishing;repaired;Reporter;Research;Small Intestines;Spleen;Structure;Testing;Tissue Extracts;Tissues;Z-Form DNA

PROJECT_TITLE: Repair of Genome Destabilizing DNA Structures

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PI_NAMEs: FERNANDEZ, SOLEDAD A (contact)

PROJECT_TERMS: Abbreviations;Adverse event;animal imaging;anti-cancer research;Area;Artificial Intelligence;Bioconductor;Biological;biomedical informatics;Biometry;Biostatistics Shared Resource;Budgets;Cancer Biology;cancer care;Cancer Center Support Grant;Cancer Control;Cancer Hospital;cancer prevention;Cancer Survivorship;Center for Translational Science Activities;Chemoprevention;Clinical;Clinical Cancer Center;Clinical Data;Clinical Sciences;clinical translation;Clinical Treatment;Clinical Trials;Collaborations;Communities;Comparative Pathology;Comprehensive Cancer Center;Data;Data Analyses;data quality;data visualization;Databases;design;Development;digital imaging;Disease;Education;Educational workshop;Electronic Health Record;Engineering;Ensure;epidemiology study;experimental study;Faculty;FAIR principles;Flow Cytometry;Funding;Future;genomic data;Genomics;Grant;Guidelines;health disparity;Health Insurance Portability and Accountability Act;Health Services Research;Hour;Immunologic Monitoring;Immunooncology;Individual;Informatics;Infrastructure;innovation;Institution;Institutional Review Boards;Intervention;Intramural Research Program;leukemia;leukemia tissue bank;Logistics;Machine Learning;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuscripts;material transfer agreement;member;Methodology;Methods;Microscopy;Mission;Modeling;Molecular Carcinogenesis;Monitor;Multi-Institutional Clinical Trial;multidimensional data;NCI Center for Cancer Research;next generation sequencing;Nutrient;Ohio;Oncology;Outcomes Research;pathology imaging;patient oriented;Pediatric Hospitals;Persons;Pharmaceutical Chemistry;Phytochemical;population based;Population Research;Population Study;Preparation;Procedures;Process;professor;programs;Proteomics;Protocols documentation;Publications;Publishing;query tools;recruit;Registries;Reporting;Reproducibility;Research;Research Activity;Research Design;Research Institute;Research Methodology;Research Personnel;research study;Resource Sharing;Resources;Review Committee;Role;Safety;Science;Scientist;Services;single-cell RNA sequencing;sound;Statistical Data Interpretation;Surveys;System;Technology;tool;Training;Training and Education;translational genomics;Translational Research;translational therapeutics;United States National Institutes of Health;Universities;Work;working group

PROJECT_TITLE: Shared Resource 03: Biostatistics (BSR)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Uveitis involving the posterior segment of the eye accounts for the highest rate of vision impairment and development of ocular complications among patients with uveitis. Current clinical evaluation of intraocular inflammation using slit lamp biomicroscopy and indirect ophthalmoscopy is operator-dependent and semi- quantitative. We will evaluate the use of optical coherence tomography to objectively quantify inflammation in these patients, which can potentially enable better detection and surveillance of uveitis so that prompt treatment can be implemented to prevent blindness and disability.

PI_NAMEs: TSUI, EDMUND  (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: 16 year old;Adrenal Cortex Hormones;Agreement;Algorithms;Antimetabolites;Appearance;Area;Biological Markers;Blindness;Cells;Clinical;clinical examination;clinical practice;Clinical Trials;Consensus;Cross-Sectional Studies;Data Set;Detection;Development;diagnostic tool;disability;Disease;Early Diagnosis;Evaluation;Eye;Eye Development;follow-up;Funding;Goals;Health;high risk;Image;Image Analysis;image processing;imaging biomarker;Immune system;immunomodulatory therapies;improved;Inflammation;inflammatory marker;Leukocytes;longitudinal analysis;Longitudinal Studies;Masks;Measurement;Measures;Methodology;Methotrexate;Modeling;Monitor;mycophenolate mofetil;Nature;Nomenclature;Ophthalmoscopy;Optical Coherence Tomography;Oral;Outcome;Outcome Measure;Panuveitis;Participant;Patients;Play;Posterior eyeball segment structure;Prediction of Response to Therapy;preservation;prevent;Randomized;randomized, clinical trials;Recommendation;Reproducibility;Research;research clinical testing;Risk;risk prediction;risk stratification;Role;secondary analysis;Signal Transduction;slit lamp imaging;Specialist;Standardization;Steroids;Strategic Planning;System;Techniques;Training;Treatment Failure;treatment response;United States Food and Drug Administration;Uveitis;Validation;Vision;vision development;Visit;Visual disability;Visual impairment;working group

PROJECT_TITLE: Objective quantification of vitreous inflammation using optical coherence tomography


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Breast Cancer;Cancer;Dementia;Immunotherapy;Lung;Lung Cancer;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Skin Cancer;Women's Health Research

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Patients with brain metastasis have limited therapeutic options and very poor prognosis. We have shown that melanoma-secreted amyloid-beta (Aβ) is required for adaptation to the brain parenchyma and that targeting Aβ secretion impairs brain metastasis in xenograft models. We propose to investigate the mechanism and therapeutic effects of Aβ inhibition (alone or in combination with immunotherapy) as a novel strategy against brain metastasis of melanoma and other tumors.

PI_NAMEs: HERNANDO, EVA  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Acceleration;Adenocarcinoma;Adrenal Cortex Hormones;Affect;Alzheimer's Disease;Alzheimer's disease patient;Amyloid beta-Protein;Amyloid beta-Protein Precursor;anti-CTLA4;anti-PD-1;anti-PD1 therapy;Antibodies;Area;Astrocytosis;Autopsy;beta secretase;Blood - brain barrier anatomy;Brain;brain dysfunction;Brain Edema;Brain Neoplasms;brain parenchyma;Breast;Breast Adenocarcinoma;Breast Carcinoma;Cancer Patient;cancer type;Cells;Cellular biology;Cephalic;Cessation of life;chemotherapy;Clinical;Clinical Trials;Combined Modality Therapy;Computational Biology;Disease;Disease Progression;efficacy evaluation;efficacy testing;Environment;Excision;experience;gamma secretase;Genetic;Glioblastoma;Growth;humanized antibody;Immune;Immune checkpoint inhibitor;Immunocompetent;Immunotherapy;Impairment;improved;in vitro Assay;in vivo Model;Inflammatory;inhibitor;insight;Investigation;ipilimumab;Link;Lung;Lung Adenocarcinoma;Lung Carcinoma;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mediator;Melanoma;Melanoma patient;Metastatic malignant neoplasm to brain;Metastatic Melanoma;Microglia;Modeling;Molecular;Mus;Neoplasm Metastasis;neoplastic cell;Nerve Degeneration;Neurocognitive Deficit;neuroinflammation;neuropsychiatry;neurosurgery;new therapeutic target;Nivolumab;novel;novel strategies;novel therapeutic intervention;objective response rate;Organ;Patient-Focused Outcomes;Patients;Phagocytosis;pharmacologic;Play;Pre-Clinical Model;Prognosis;Proteins;Proteomics;Radiosurgery;Resistance;Resolution;response;Role;Safety;Sampling;single-cell RNA sequencing;small molecule;standard of care;Systemic Therapy;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Effect;transcriptomics;Tropism;tumor;tumor microenvironment;tumorigenesis;Up-Regulation;Xenograft Model

PROJECT_TITLE: Developing new therapeutic strategies for brain metastasis

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


PI_NAMEs: MISHRA, PRAVIN K (contact)

PROJECT_TERMS: Abbreviations;Adopted;animal imaging;Applications Grants;Biological;Biological Assay;Biological Markers;biomedical informatics;Biomedical Research;Biometry;Budgets;Cancer Biology;cancer cell;Cancer Center Support Grant;Cancer Control;Cancer Hospital;cancer prevention;Cancer Survivorship;Cell Culture Techniques;Cell Line;Cells;Chemoprevention;Clinical Investigator;clinical translation;Clinical Treatment;clinical trial protocol;Clinical Trials;Comparative Pathology;Complex;Comprehensive Cancer Center;Consultations;cytotoxicity;Data;Data Analyses;design;Development;digital;digital imaging;Disease;drug development;Drug Synergism;Dryness;Engineering;Equipment;Flow Cytometry;Fostering;Funding;Future;Genomics;Goals;Grant;Growth;Hematologic Neoplasms;Hematology;Hour;Human;human data;Immunohistochemistry;Immunologic Monitoring;Immunooncology;innovation;Institution;Institutional Review Boards;instrument;Intervention;Intramural Research Program;Investments;Laboratories;leukemia;leukemia tissue bank;Liquid substance;Malignant Neoplasms;Manuscripts;material transfer agreement;member;Microscopy;Migration Assay;Molecular Carcinogenesis;Names;next generation sequencing;nucleic acid purification;Nutrient;Ohio;pathology imaging;Patients;Pediatric Hospitals;Pharmaceutical Chemistry;Phase;Phytochemical;Population;Population Sciences;pre-clinical;preclinical toxicity;Preparation;Process;programs;Promega;Protein Array;Proteins;Proteomics;protocol development;Protocols documentation;Publications;rapid growth;recruit;Research;Research Design;Research Institute;Research Personnel;Resource Sharing;Resources;Sampling;Science;Scientist;Services;Signal Transduction;Solid Neoplasm;Specific qualifier value;Surveys;synergism;System;Therapeutic;Time;Tissue Procurements;Toxicity Tests;translational genomics;translational goal;Translational Research;translational therapeutics;tumor;Universities;Vendor

PROJECT_TITLE: Shared Resource 04: Clinical-Translational Science (CTSSR)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE Alzheimer’s disease is a growing public health crisis that has been difficult to study and to develop effective treatments due to a two-to-three-decade-long time between when abnormal proteins can be measured in the brain and the onset of disease symptoms that affect memory and thinking. This study will use a new concept to study Alzheimer’s disease brain changes and symptom progression based on a new statistical technique developed by the study PI that allows estimation of when the disease began utilizing a brain scan called positron emission tomography that measures abnormal buildup of a protein called beta-amyloid. Applying this new concept to data from multiple existing studies (>5,000 people) is expected to provide new information about the things that affect how fast the disease progresses, which will inform when patients with Alzheimer’s disease should be treated to have the greatest therapy benefits.

PI_NAMEs: BETTHAUSER, TOBEY JAMES (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Acceleration;Accounting;Affect;Age;Age of Onset;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Amyloid deposition;apolipoprotein E-4;Autopsy;Biological;Biological Aging;Biological Assay;Biological Factors;Biological Markers;Brain;brain based;Brain scan;brain volume;Cerebrospinal Fluid;Clinic;Clinical;Clinical Trials;Clinical Trials Design;Cognition;cohort;Cohort Studies;Combined Modality Therapy;comorbidity;cost;Data;Dementia;dementia risk;Demographic Factors;demographics;Detection;Disease;Disease Progression;Economic Conditions;Education;effective therapy;Environmental Risk Factor;Event;experience;Genetic;Health;Health behavior;Heterogeneity;Image;Impaired cognition;improved;Individual;insight;Intervention;Investigation;Link;Liquid substance;Magnetic Resonance Imaging;Measurable;Measures;Mediator;Memory;Methods;Modeling;Modification;Monitor;neighborhood disadvantage;Nerve Degeneration;Neurobehavioral Manifestations;Neurofibrillary Tangles;neuroimaging;neuroimaging marker;neuropathology;novel;novel strategies;Onset of illness;optimal treatments;Participant;Pathologic;Pathology;Patients;Persons;Phase;polygenic risk score;Positron-Emission Tomography;pre-clinical;prevent;Prevention therapy;Proteins;Public Health;recruit;Registries;Research;Research Design;response;Risk;Risk Factors;risk prediction;Sampling;sex;Shapes;Social Conditions;social factors;social health determinants;sociocultural determinant;sociodemographics;Source;Standardization;Stereotyping;Sum;Symptoms;tau Proteins;Techniques;Testing;Thinking;Time;timeline;tool;Translating;Translations;Universities;uptake;Variant;Vascular Diseases;Washington;Wisconsin;Work

PROJECT_TITLE: Multi-cohort study of factors that influence Alzheimer's disease biomarker and dementia timing


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative The proposed research is relevant to public health because it will yield a better understanding of risk in autism and thus will lead to improved methods for prevention and treatment. By our exploration of de novo and transmitted variation, it is also relevant to the NIH mission and to the IACC recommendations around identifying genetic risk in ASD.

PI_NAMEs: ROEDER, KATHRYN M (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Adult;Affect;analytical method;ANK2 gene;autism spectrum disorder;autism symptoms;Brain Diseases;cell type;Clinical;cohort;Copy Number Polymorphism;Data;Development;developmental disease;Diagnosis;Disease;disorder risk;exome;Family;First Pregnancy Trimester;Foundations;functional genomics;gain of function;gene discovery;General Population;Genes;Genetic;genetic architecture;Genetic Risk;Genetic Variation;genomic data;Goals;Heterogeneity;improved;Individual;Inherited;innovation;insertion/deletion mutation;insight;International;Knowledge;Learning;Link;loss of function;Mental disorders;Methods;Mission;Mutation;Neurodevelopmental Disorder;neuropsychiatric disorder;novel;novel therapeutics;Nucleotides;Outcome;Pathogenesis;Pathway interactions;Pattern;Play;Population;population based;Prevention;Process;Public Health;rare variant;Recommendation;repetitive behavior;Research;Research Project Grants;Resources;RFX3;Risk;risk variant;Role;Sampling;Sequence Analysis;sex;Signal Transduction;Site;social deficits;Source;Statistical Methods;Symptoms;therapeutic target;Trans-Omics for Precision Medicine;transmission process;United States National Institutes of Health;Variant;whole genome

PROJECT_TITLE: 3/4 The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(60)]


NIH_SPENDING_CATS: Cancer

ORG_NAME: OHIO STATE UNIVERSITY

PI_NAMEs: OTTERSON, GREGORY A (contact)

PROJECT_TERMS: Abbreviations;Address;Air;Ambulatory Care;animal imaging;Appointment;Basic Science;Biological;biomedical informatics;Biomedical Research;Biometry;Brain;Budgets;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Hospital;cancer therapy;Chemoprevention;Chest;Clinical;Clinical Research;clinical translation;Clinical Treatment;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;Collection;Comparative Pathology;Complex;Comprehensive Cancer Center;Consultations;cost effective;Dangerousness;design;Development;digital imaging;Disease;drug development;Drug Kinetics;early phase clinical trial;Electronics;expectation;first-in-human;Floor;Flow Cytometry;Funding;Genomics;Grant;Growth;Gynecologic Oncology;Hematology;Hospitals;Human;Immunologic Monitoring;Immunooncology;improved;Institution;International;Intervention;Intramural Research Program;Investigational Therapies;investigator-initiated trial;Laboratories;leukemia;leukemia tissue bank;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Medical Oncology;meetings;member;Microscopy;Mission;Molecular Carcinogenesis;Monitor;NCI Center for Cancer Research;Nutrient;Ohio;oncology service;participant enrollment;pathology imaging;Pediatric Hospitals;Pharmaceutical Chemistry;Pharmacodynamics;Pharmacogenomics;Phase;Phytochemical;Play;programs;Proteomics;Protocols documentation;Publications;recruit;Research;Research Institute;Research Personnel;Resource Sharing;Retirement;Role;sample collection;Sampling;Services;Shipping;Site;Specific qualifier value;Specimen;Specimen Handling;Surveys;System;translational clinical trial;translational genomics;Translational Research;translational therapeutics;Transportation;United States Food and Drug Administration;Universities;Validation;Vertebral column;Visit

PROJECT_TITLE: Shared Resource 05: Clinical Treatment Unit/ Clinical Trials Processing Lab (CTU/CTPL-SR)


ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

PHR: PROJECT NARRATIVE The goal of this research project is to produce mechanistic insights into kindlin-3 signaling in neutrophils, and provide opportunities for developing more specific and safer anti-inflammatory strategies for treating complications in a whole host of inflammatory diseases, including the recently described inflammatory complications present in COVID-19.

PI_NAMEs: MA, YAN-QING  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acute Lung Injury;Anti-Inflammatory Agents;Arginine;Binding;Biology;Cells;Chemotaxis;Chronic;Co-Immunoprecipitations;COVID-19;Cytoplasmic Tail;Decision Trees;Disease;Endotoxemia;Event;Excision;experimental study;extracellular;Goals;Hematopoietic;HL-60 Cells;Human;Hydrolase;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Innate Immune Response;insight;Integrin beta Chains;Integrin Binding;Integrins;Lysine;Mediating;Methods;multicatalytic endopeptidase complex;Mus;mutant;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;Pathologic;Play;Predisposition;Process;Production;Property;Reactive Oxygen Species;Regulation;Research Project Grants;Resistance;response;Role;screening;Signal Transduction;Site;Sterility;Stimulus;Testing;Tissues;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;yeast two hybrid system;Yeasts

PROJECT_TITLE: Kindlin-3 signaling in neutrophils

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: RELEVANCE STATEMENT    Stress granules and their components have been implicated in various biological processes related to human  health including regulation of infectious, inflammatory, and neurodegenerative diseases. However, there is a  major  gap  in  the  field  regarding  the  intersection  between  innate  immune  response  and  stress  response  in  multiple human diseases, including viral infections. Our proposal will uncover the mechanisms governing the  cross- talk between stress  response and host  innate  immune  pathways that dictate  protective or pathogenic  host response which could be targeted therapeutically.

PI_NAMEs: KANNEGANTI, THIRUMALA-DEVI  (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: Affect;Affinity Chromatography;Apoptosis;Area;biological adaptation to stress;Biological Process;CASP1 gene;Cell Death;Cell Survival;Cells;Cellular Stress;Communicable Diseases;Cues;cytokine;Cytosol;Data;Disease;experimental study;Grant;Health;helicase;Homeostasis;Human;human disease;IL18 gene;Immune;Immune response;Immune signaling;Immunity;Immunology;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Influenza A virus;influenza infection;influenzavirus;innate immune pathways;Innate Immune Response;interest;Interleukin-1 beta;Link;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane;membrane assembly;microbial;Molecular;Mus;Mutation;Myeloid Cells;Natural Immunity;Nature;Neurodegenerative Disorders;new therapeutic target;pathogen;pathogenic microbe;Pathogenicity;Pathway interactions;Pattern;Physiological;Play;Positioning Attribute;Predisposition;Production;Progress Reports;protein complex;Publications;Publishing;receptor;Regulation;response;RNA;Role;Science;sensor;Shapes;Signal Pathway;Signal Transduction;Stress;stress granule;Syndrome;targeted treatment;Testing;Viral;Virus;Virus Diseases;Z-DNA Binding Protein

PROJECT_TITLE: Innate immune signaling and stress response


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE This project quantitatively and qualitatively investigates and disseminates the mechanisms underlying potential racial/ethnic and sex disparities in substance use disorder treatment services among justice-involved adolescents, a health disparity population prone to suffer harsher consequences from substance misuse. Adopting a team science approach, the project integrates a sociological theory of health disparities, the juvenile justice behavioral health services cascade of care, mediation analysis with longitudinal structural equation modeling, stress instrumentation, and hybrid thematic analysis with cutting-edge technologies. The project will lead to the development and testing of culturally appropriate, sex-responsive, and trauma-informed SUD risk assessment protocols and disparity reduction interventions in the juvenile justice system.

PI_NAMEs: JOHNSON, MICAH  (contact)

PROGRAM_OFFICER_NAME: MULFORD, CARRIE FRIED

PROJECT_TERMS: 18 year old;Address;Adolescence;Adolescent;Adopted;Awareness;behavioral health;Caring;Cessation of life;clinical diagnosis;Communities;community-centered;Computer software;Coupled;Criminal Justice;Data;Data Analyses;Databases;design;Development;Diagnosis;diagnostic criteria;disorder prevention;Disparity;disparity reduction;Drug Courts;Drug usage;Education;Equation;ethnic difference;ethnic disparity;ethnic identity;ethnic minority;Ethnic Origin;Ethnic Population;Etiology;experience;Exposure to;Female;Florida;Fostering;Foundations;Gender;Goals;Health;health disparity;health disparity populations;Health Services;Health Services Accessibility;high risk sexual behavior;Hybrids;implementation science;Imprisonment;improved;Individual;innovation;insight;instrumentation;Intervention;Interview;Justice;juvenile justice system;Knowledge;Life;Link;longitudinal database;longitudinal design;Longitudinal Studies;Manuscripts;Measures;Mediating;Mediation;Mentors;Methodology;Methods;Minor;Minority;Minority Groups;Minority Health Research;Mission;Modeling;Monitor;National Institute of Drug Abuse;novel;Occupational;Outcome;Ozone;Paper;Participant;Pathway interactions;Pattern;Perception;person centered;Population;Prevention;Process;protective factors;Protocols documentation;psychological outcomes;Psychometrics;Publishing;Qualitative Methods;Race;racial difference;racial disparity;racial identity;racial minority;recidivism;Recommendation;Research;Research Activity;Resources;Risk;Risk Assessment;Risk Factors;Sampling;Science;screening;service delivery;Services;sex;Sex Differences;sex disparity;sexual identity;Sociology;Source;Strategic Planning;Stress;Stress Tests;stressor;substance misuse;Substance Use Disorder;substance use prevention;substance use treatment;Surveys;synergism;System;Technology;Testing;theories;Training;Translational Research;Trauma;treatment disparity;treatment services;Underserved Population;United States;Violence

PROJECT_TITLE: Examining the Stress Processes Relating Ethnicity and Sex to Substance Misuse and Services Outcomes (ESPRESSO)

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Regenerative Medicine;Rehabilitation

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  Older people with lower extremity peripheral artery disease (PAD) have greater walking impairment and faster functional decline than those without PAD. Yet few therapies have been identified that improve disability in people with PAD. This randomized clinical trial will collect preliminary evidence to determine whether far red light therapy of the lower extremities improves walking impairment in older people with PAD, compared to a sham light device. If our hypotheses are correct, results will be used to design and conduct a large clinical trial of far red light therapy for PAD.

PI_NAMEs: MCDERMOTT, MARY MCGRAE (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Acute;Affect;Age;angiogenesis;Animal Model;arterial spin labeling;Biological;Biological Availability;Biopsy;Blood capillaries;Blood flow;Cell Nucleus;Chronic;Clinical Trials;Data;density;design;Devices;disability;Disabled Persons;Dose;enzyme activity;follow-up;functional decline;Functional impairment;functional improvement;Gait abnormality;Gastrocnemius Muscle;Health;Home;Hour;Human;human old age (65+);Impairment;improved;Intervention;Ischemia;ischemic injury;Leg;Light;limb ischemia;Lower Extremity;Magnetic Resonance Imaging;Measures;men;Mitochondria;Muscle;Muscle Fibers;Muscle Mitochondria;Muscle satellite cell;Nitric Oxide;Nitrites;Older Population;Outcome;Oxidative Stress;Participant;Pathology;Pathway interactions;Patient Outcomes Assessments;Patients;Performance;Perfusion;Peripheral arterial disease;Persons;Phase;phase II trial;Phototherapy;Pilot Projects;Plasma;pre-clinical;preclinical study;Preparation;prevent;primary outcome;Property;Quality of life;Questionnaires;Randomized;randomized trial;randomized, clinical trials;repaired;Reperfusion Injury;secondary outcome;Signaling Molecule;Skeletal Muscle;Source;Testing;Therapeutic;treadmill;Vascular Endothelial Growth Factors;Walking;walking performance;Woman;Work

PROJECT_TITLE: Far Red Light to Improve Functioning in PAD: the LIGHT PAD Trial

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Bioengineering;Cancer;Prevention

ORG_CITY: Columbus

PI_NAMEs: LA PERLE, KRISTA MARIE DUBRAY (contact)

PROJECT_TERMS: Abbreviations;Address;age related;Algorithms;Anatomy;animal imaging;Animal Model;animal tissue;Animals;Antibodies;Biological Markers;biomedical informatics;Biomedical Research;Biometry;Board Certification;Breeding;Budgets;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Hospital;cancer prevention;Cancer Survivorship;cancer therapy;carcinogenesis;Chemoprevention;clinical translation;Clinical Treatment;Clinical Trials;college;comparative;Comparative Pathology;Complement;Complex;Comprehensive Cancer Center;Computer software;Custom;Data Analyses;Development;Diagnostic;digital imaging;Engineering;experience;Experimental Designs;Experimental Pathology;Flow Cytometry;Fostering;Funding;Genomics;Grant;Histology;Hour;Human;Human Pathology;human tissue;IACUC;Image;Image Analysis;Immunofluorescence Immunologic;Immunohistochemistry;Immunologic Monitoring;Immunooncology;improved;In Situ Hybridization;Informatics;Intervention;Intramural Research Program;Laboratories;Lesion;leukemia;leukemia tissue bank;Machine Learning;Malignant Neoplasms;Medicine;meetings;member;Mentored Clinical Scientist Development Program;Microscopy;Minor;Molecular Carcinogenesis;Mus;Names;NCI Center for Cancer Research;Nutrient;Ohio;open source;Pathologic;Pathologist;Pathology;pathology imaging;Peer Review;Pharmaceutical Chemistry;Phenotype;Physiological;Phytochemical;pre-clinical;preclinical efficacy;preclinical toxicity;programs;Proteins;Proteomics;Publications;quantitative imaging;recruit;Research;Research Institute;Research Personnel;Resource Sharing;RNA;Sampling;Services;Slide;Stains;Surveys;tissue biomarkers;Tissue Procurements;Tissues;translational genomics;translational impact;Translational Research;translational study;translational therapeutics;treatment response;tumor progression;Universities;Validation;Veterinary Medicine;Veterinary Pathology;Workload

PROJECT_TITLE: Shared Resource 06: Comparative Pathology and Digital Imaging (CPDISR)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Influenza;Mental Health;Mental Illness;Neurosciences;Patient Safety;Pediatric;Pneumonia and Influenza

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE There is no scientific consensus as to whether the antiviral drug, oseltamivir (Tamiflu), the recommended treatment for influenza infection, is associated with neuropsychiatric adverse events (e.g., suicide, psyhocis, seizures etc). This proposal seeks to define the relationship between influenza, oseltamivir, and neuropsychiatric adverse events in children. Results of this research will inform the safety profile of the medication and guide clinical care to optimize outcomes in children with influenza.

PI_NAMEs: ANTOON, JAMES W (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: ABCB1 gene;Active Learning;Address;Adverse drug event;Adverse effects;Adverse event;Algorithms;Anti-Arrhythmia Agents;Anti-viral Agents;Antibiotics;Award;Biological;Blood;Brain;career;career development;Caregivers;Case Series;Child;Childhood;Chronic;clinical care;Clinical Investigator;Clinical Pharmacology;clinical practice;Collaborations;Communicable Diseases;Consensus;Coupled;Data;Databases;design;Diffusion;Disease;Drug Interactions;Drug Modulation;Drug usage;Ensure;Evaluation;Event;experience;Exposure to;Family;Feeling suicidal;gamma-Aminobutyric Acid;Glucocorticoids;Goals;High Prevalence;high risk;Hospitalization;Hospitals;improved;Incidence;Infection;Infectious Disease Epidemiology;Influenza;influenza infection;inhibitor;Kidney Diseases;Knowledge;Laboratories;Leadership;Life;lipophilicity;Literature;Medicaid;Medical;medication safety;Mental disorders;Mentors;Methodology;Methods;Morbidity - disease rate;mortality;multidisciplinary;N-Methylaspartate;Neurologic;neuropsychiatric symptom;neuropsychiatry;Observational Study;Oseltamivir;Outcome;Outpatients;Patients;Pediatric Hospitals;Pediatrics;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacology;Pharmacy facility;Population;population based;Population Study;programs;Proton Pump Inhibitors;Provider;psychiatric comorbidity;Psychoses;randomized trial;Recommendation;Recording of previous events;Reporting;Research;Research Design;Research Infrastructure;Research Training;Retrospective cohort study;Retrospective Studies;Risk;Safety;Schizophrenia;secondary analysis;Seizures;shared decision making;Signal Transduction;skills;socioeconomic disadvantage;Suicide;Surveys;Symptoms;System;Tennessee;Testing;Training;United States Food and Drug Administration;Viral;Vital Statistics;Work

PROJECT_TITLE: Oseltamivir Use and Risk of Serious Neuropsychiatric Adverse Events in Children

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Organ Transplantation;Pneumonia and Influenza;Prevention;Transplantation;Vaccine Related

PHR: NARRATIVE Influenza virus is a significant pathogen in lung transplant recipients, but these patients respond poorly to standard-dose (SD) inactivated influenza vaccine (IIV). Studies suggest that two doses of SD-IIV or one dose of high-dose (HD-IIV) is superior to one dose of SD-IIV in solid organ transplant recipients; however, these strategies to improve immunogenicity have neither been extensively tested in lung allograft recipients nor have they been assessed in the early post-transplantation period when allograft recipients are at highest risk of severe influenza disease and complications. This study aims to compare two doses HD-quadrivalent inactivated influenza vaccine (QIV) or two doses SD-QIV in lung allograft recipients ≥16 years of age 1-35 months post-transplant.

PI_NAMEs: HALASA, NATASHA BASSAM (contact)

PROJECT_TERMS: 16 year old;Academic Medical Centers;Ache;Acute;Address;Adult;Adverse event;Alabama;Allografting;Antibodies;Antibody titer measurement;Antigens;B-Lymphocyte Subsets;B-Lymphocytes;Biopsy;CD4 Positive T Lymphocytes;Cellular Assay;Chronic;Clinical;comorbidity;Cytometry;Development;Disease;Dose;Double-Blind Method;Enrollment;Environmental Exposure;Evaluation;exhaustion;Fatigue;Fever;Frequencies;Functional disorder;Headache;Hemagglutination;high risk;HLA Antigens;Immune response;immunogenic;immunogenicity;Immunologics;Immunophenotyping;immunosuppressed;Immunosuppression;improved;Individual;Induration;Influenza;Influenza A virus;Influenza B Virus;Influenza vaccination;influenza virus vaccine;influenzavirus;Injections;Knowledge;lung allograft;Lung Transplantation;Malaise;Measurement;Measures;Morbidity - disease rate;Myalgia;Nausea;organ transplant recipient;Organ Transplantation;Pain;pathogen;Patients;Phase;phase II trial;Phenotype;Population;post-transplant;preservation;Prevention strategy;Publishing;Randomized;Reaction;Recommendation;Redness;Regimen;Reporting;Respiratory Failure;response;Risk;Safety;seasonal influenza;Seasons;senescence;Serious Adverse Event;seroconversion;Severities;side effect;Site;Solid;Swelling;T-Cell Activation;T-Lymphocyte;Testing;transplant centers;Transplant Recipients;trial comparing;Universities;Vaccination;vaccination strategy;Vaccine Antigen;vaccine immunogenicity;vaccine strategy;vaccine trial;Vaccines;Vomiting;Washington

PROJECT_TITLE: Comparison of High Dose vs. Standard Dose Influenza Vaccines in Lung Allograft Recipients


PI_NAMEs: CHALMERS, JEFFREY JOHN (contact)

PROJECT_TERMS: Abbreviations;Academic Medical Centers;Address;Agreement;animal imaging;anti-cancer research;assay development;base;biomedical informatics;Biometry;Budgets;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Hospital;cancer prevention;Cancer Research Project;cancer risk;Cancer Survivorship;Cell Separation;Cells;Chemicals;Chemoprevention;clinical translation;Clinical Treatment;Clinical Trials;commercialization;Communication;Comparative Pathology;Complex;Comprehensive Cancer Center;Computer software;Consultations;Cytometry;Development;digital imaging;Disease;Education and Outreach;Educational workshop;Engineering;Equipment;exosome;Experimental Designs;extracellular;extracellular vesicles;Faculty;Fee-for-Service Plans;Flow Cytometry;Flow Cytometry Shared Resource;fluorescence microscope;Funding;Genomics;Grant;Hour;Image Analysis;Immune system;Immunologic Monitoring;Immunooncology;industry partner;Institution;Institutional Review Boards;instrument;instrumentation;Intervention;Intramural Research Program;Laboratories;Lasers;leukemia;leukemia tissue bank;magnetic cell separation;Magnetism;Malignant Neoplasms;material transfer agreement;member;Mentored Clinical Scientist Development Program;Methodology;Methods;microbiome;Microscopy;microvesicles;Mission;Molecular Carcinogenesis;Names;new technology;Nutrient;Ohio;operation;pathology imaging;Pediatric Hospitals;Pharmaceutical Chemistry;Phytochemical;Positioning Attribute;Procedures;programs;Proteomics;Publications;recruit;Research;Research Institute;Research Personnel;Resource Sharing;Resources;RNA;Services;Sorting;Supporting Cell;Surveys;System;Technical Expertise;Technology;technology development;Testing;Time;Training;Training Programs;translational genomics;Translational Research;translational therapeutics;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Shared Resource 07: Flow Cytometry (FCSR)


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The major goals of this study are to develop a generalizable method to resolve the exact genome segmental duplication rearrangements underlying large copy number variants (CNVs), to apply the method in a group of affected individuals with the 16p11.2 CNVs and determine the rearrangement diversity across different individuals, to develop high-throughput genotyping assays for future large-cohort association studies in an expand group of affected individuals, and to investigate the functional consequences of rearrangement diversity using neuronal organoid models. The methodological framework established here for studying the 16p11.2 CNVs can be used to study the other large CNVs that are strongly associated with psychiatric disorders such as 22q11, 15q13, and 1q21.

PI_NAMEs: ZHOU, BO  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: 16p11.2;1q21;22q11;22q11.2;Achievement;Affect;autism spectrum disorder;Base Pairing;Biological;Biological Assay;Biology;career;career development;Career Mobility;Cell Line;cell type;Cells;Chromatin;Chromosome abnormality;Cicatrix;Clinical;cohort;Complex;Copy Number Polymorphism;CRISPR/Cas technology;Development;digital;Disease;DNA;DNA mapping;established cell line;Etiology;experience;Functional disorder;functional outcomes;Funding;Future;Gene Expression;Gene Expression Profile;Gene Fusion;Genetic;Genetic Polymorphism;Genetic Transcription;Genetic Variation;Genome;genome analysis;genome sequencing;Genomic DNA;Genomic Segment;Genomics;Genotype;Goals;Grant;Haplotypes;homologous recombination;Human;Individual;induced pluripotent stem cell;Knowledge;Mediating;Mental disorders;Mentorship;Methodology;Methods;Modeling;Molecular;neural;Neurons;neuropsychiatric disorder;neuropsychiatry;Neurosciences;novel;novel strategies;Optics;Organoids;Outcome;paralogous gene;Phenotype;Principal Investigator;psychogenetics;Research;Research Personnel;research study;Resolution;Risk Factors;Sampling;Schizophrenia;schizophrenia risk;Secure;Sequence Deletion;Stretching;Time;Training;Universities;Writing

PROJECT_TITLE: A novel method to resolve the complex genome rearrangements of the large copy number variants (CNVs) associated with psychiatric disorders

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]