PHR: Anxiety and depression symptoms occur at high rates in Veteran populations and can significantly impact function, compromising the ability to work and to successfully form and maintain valued relationships. Several other symptoms commonly occur with anxiety and depression, including poor sleep quality and chronic pain. Since all these symptoms frequently occur together, they may have a common underlying biological basis. A single medication that could effectively treat all these symptoms would be ideal. Converging data suggest that pregnenolone is a promising pharmacological agent for treating multiple psychiatric symptoms and functional impairment. We thus propose to conduct a clinical trial of pregnenolone in Veterans with anxiety and depression symptoms. Pregnenolone has minimal side effects, and our prior research demonstrates that pregnenolone is well-tolerated by Veterans. Treatment with pregnenolone could thus be an efficacious new therapeutic for Veterans experiencing depression, anxiety, poor sleep quality and chronic pain conditions.

PI_NAMEs: MARX, CHRISTINE E.;NAYLOR, JENNIFER C (contact)

PROJECT_TERMS: addiction;Aftercare;Allopregnanolone;Analgesics;Anti-Anxiety Agents;anti-depressive agents;Anti-Inflammatory Agents;Anxiety;Anxiety Disorders;anxiety symptoms;anxiety treatment;associated symptom;Asthma;Behavioral Symptoms;Benzodiazepines;Biological;candidate marker;Chronic;chronic pain;chronic painful condition;Classification;Clinical;clinical biomarkers;Clinical Data;Clinical Trials;cohort;common symptom;completed suicide;Data;depressive symptoms;Diabetes Mellitus;Diagnosis;Diagnostic;disability;Disease;Dose;Double-Blind Method;double-blind placebo controlled trial;DSM-V;Enrollment;Exhibits;experience;FDA approved;flexibility;functional disability;Functional disorder;Functional impairment;functional improvement;functional outcomes;Future;Goals;Health;Hypertension;improved;inflammatory marker;Interleukin-6;Intervention;Lead;Low Back Pain;Mass Spectrum Analysis;Medical;Mental Depression;Mental Health;Methods;military veteran;Mood Disorders;neurosteroids;novel;novel therapeutics;overdose risk;Pain;Pain Disorder;Pain quality;pain reduction;pain symptom;Pharmaceutical Preparations;pharmacologic;phase III trial;Placebos;poor sleep;Population;Postpartum Depression;pre-clinical;Pregnenolone;psychiatric symptom;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Recurrence;Research;response;restoration;Risk;Rodent Model;Role;Safety;secondary endpoint;secondary outcome;Selective Serotonin Reuptake Inhibitor;Serum;side effect;Sleep;Sleep disturbances;sleep quality;symptomatic improvement;Symptoms;Techniques;Testing;Therapeutic;TNF gene;Treatment Efficacy;treatment response;Tricyclic Antidepressive Agents;Veterans;Work

PROJECT_TITLE: A New Intervention to Improve Function in Veterans with Anxiety and Depression


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Childhood Obesity;Hematology;Neurosciences;Nutrition;Obesity;Osteoporosis;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Patients with acute lymphoblastic leukemia (ALL) who are obese have a much higher risk of relapse than those who are not obese. We found that fat tissue induces expression of a protein called RANKL in ALL cells, which might contribute to this poorer outcome. In the present study, we are investigating how this occurs as well as strategies to intervene.

PI_NAMEs: MITTELMAN, STEVEN DAVID (contact);ORGEL, ETAN

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: acute lymphoblastic leukemia cell;Acute Lymphocytic Leukemia;Adipocytes;Adipose tissue;Adolescent and Young Adult;Adult;adult obesity;Apoptosis;Autocrine Communication;Body fat;bone;Bone Density;bone invasion;bone loss;Bone Resorption;Central Nervous System;Central Nervous System Leukemia;Cephalic;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Child;Clinical;cost;Diagnosis;Diet;diet-induced obesity;differential expression;Dinoprostone;Disease;Dual-Energy X-Ray Absorptiometry;Enrollment;ethnic minority;experience;experimental study;Fatty acid glycerol esters;FDA approved;Fracture;fracture risk;Genes;Grant;Growth;high risk;Impairment;improved;in vivo;Infiltration;Invaded;leukemia relapse;Ligands;Malignant Childhood Neoplasm;Malignant Neoplasms;Marrow;Mediating;Modeling;Morbidity - disease rate;mouse model;Mus;Musculoskeletal;Newly Diagnosed;novel;novel strategies;Nuclear;obese patients;Obesity;Osteoclasts;Osteopenia;Outcome;Pathway interactions;Patients;Population;Prevention;prognostic;programs;Proteins;Proto-Oncogene Proteins c-akt;racial minority;receptor;Receptor Cell;receptor expression;Relapse;relapse risk;Reporting;research clinical testing;Residual Neoplasm;Sampling;Siblings;Signal Transduction;single-cell RNA sequencing;Site;Solid;Specimen;spine bone structure;Surface;Survivors;Testing;Tissues;translational approach;Treatment Failure;Treatment outcome;treatment response;Youth

PROJECT_TITLE: Adipose Tissue Reprograms Acute Lymphoblastic Leukemia Cells to Facilitate CNS and Bone Invasion

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (J2)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Services;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE  Despite national quality measures and care guidelines, cirrhosis care remains suboptimal and highly variable, leading to poor outcomes. Clinical decision support systems represent an attractive strategy to improve care due to low implementation costs, but these systems remain largely untested in cirrhosis care. This proposal will close this evidence gap by conducting a pragmatic randomized controlled trial of a cirrhosis-specific clinical decision support system, named “CirrhosisRx,” evaluating its implementation outcomes, and identifying factors for successful multicenter dissemination.

PI_NAMEs: GE, JIN  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Address;Adherence;Adopted;Adoption;Affect;American;artificial intelligence algorithm;Biometry;Body System;California;career development;Caring;Cirrhosis;Clinical;clinical decision support;Clinical Decision Support Systems;clinical development;Clinical Informatics;Collaborations;Complex;Data;Data Analyses;Dedications;design;Development;Development Plans;Effectiveness;Electronic Health Record;Electronics;Equation;Evaluation;Foundations;Future;Gastroenterology;Geography;Guideline Adherence;Guidelines;Health;Health system;Hepatology;Hospital Mortality;hospital readmission;Hospitalization;Hospitals;human centered design;implementation cost;implementation outcomes;implementation science;improved;improved outcome;Inpatients;Institution;Intervention;Interview;Knowledge;Leadership;Liver diseases;Machine Learning;Maintenance;Measures;Mediating;Medicine;Mentored Patient-Oriented Research Career Development Award;Mission;Modeling;mortality;multidisciplinary;Names;novel;Outcome;Patient Care;Patient Readmission;Patient-Focused Outcomes;Patients;point of care;Policies;primary outcome;professor;programs;Qualitative Methods;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reproducibility;Research Personnel;Research Support;risk stratification;San Francisco;Site;skills;Source;Statistical Methods;Structure;Supervision;System;Technology;Testing;Training;treatment as usual;trial design;United States;Universities;Variant;Work

PROJECT_TITLE: A pragmatic RCT to evaluate the effect of CirrhosisRx, a novel clinical decision support system, versus usual care on guideline-adherence and clinical outcomes for patients with cirrhosis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

PHR: NARRATIVE The central goal of this proposal is to improve capacity, access, and equity for underserved, vulnerable, and minority populations being served by the UCSF long COVID OPTIMAL clinic program. Using an implementation science approach and leveraging the existing OPTIMAL Long COVID care model and established relationships with community and research we propose to: 1) Scale up Long COVID care in the San Francisco Bay Area to increase access for underserved, vulnerable, and minority populations; 2) Enhance Long COVID care coordination and communication across clinical, research, and community settings; 3) Identify key barriers and facilitators to implementation success and sustainability of the expanded and enhanced Long COVID care model.

PI_NAMEs: JAIN, VIVEK ;PELUSO, MICHAEL JOSEPH;SANTHOSH, LEKSHMI  (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Broadening the scale and impact of a comprehensive Long COVID clinic to serve diverse patient groups with multidisciplinary care and research access

STUDY_SECTION_NAME: Special Emphasis Panel[ZHS1 HSR-H (01)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE The proposed work aims to determine the relationship of neighborhood-level SDH, prematurity, and long-term health outcomes among Black children, to identify family-prioritized SDH and preferred approaches to interventions, and to determine the feasibility and acceptability of a novel SDH intervention among Black families with preterm infants. It is relevant to public health in that findings will inform a future intervention specifically designed to address SDH to improve the long-term health of Black children born preterm, a NIMHD priority population. Developing effective interventions to address SDH that influence immediate and long-term child health and development is crucial to realizing the NIMHD mission to reduce and ultimately lead to the elimination of health disparities.

PI_NAMEs: KARVONEN, KAYLA  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: 5 year old;acceptability and feasibility;Address;adverse outcome;Birth;Black race;California;care systems;Caregivers;Cause of Death;Cessation of life;Child;Child Development;Child Health;Child health care;Childhood;Clinic;Clinical;Code;cohort;comorbidity;Computerized Medical Record;Data;Death Rate;design;Development;disease disparity;disorder risk;Economics;Education;effective intervention;environmental justice;Environmental Risk Factor;Equity;evidence base;Exposure to;Family;Funding;Future;Goals;Grant;Health;health care service utilization;health determinants;health disparity;health inequalities;Healthcare;high risk;high risk population;Hospitals;implementation evaluation;implementation science;improved;indexing;Individual;Infant;innovation;insight;Intervention;Intervention Trial;Interview;K-Series Research Career Programs;knowledge base;Longitudinal cohort;Low Birth Weight Infant;Measures;Mediating;Mentors;Mentorship;Methodology;Methods;Mission;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;National Institute on Minority Health and Health Disparities;neighborhood association;Neighborhoods;neonatal outcome;neurodevelopment;novel;Outcome;pediatric health outcomes;Perinatal;Physicians;poor health outcome;Population;Population Intervention;premature;Premature Birth;Premature Infant;prevent;primary care services;Process;Process Measure;Professional Organizations;programs;Provider;Public Health;Publications;Qualitative Research;Race;racial disparity;racial diversity;Recommendation;recruit;Research;Research Personnel;Risk;Sampling;San Francisco;satisfaction;Scientist;screening;social;socioeconomics;Source;Structural Racism;Structure;Surveys;Sustainable Development;Testing;theories;therapy design;Training;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Identifying and addressing family-prioritized social drivers of health to improve the long-term health of Black preterm infants

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (J1)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE This research will enhance public health by improving the safety and efficacy of drugs that treat diseases of the central nervous system (CNS) in children. Specifically, this research will provide significant new insight regarding the mechanisms of drug passage into the CNS of children and enable optimal, patient-specific pharmacotherapy to treat CNS diseases in children.

PI_NAMEs: HUNT, J PORTER (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: Address;Affect;Age;age difference;Award;Binding Proteins;Biological Markers;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Brain;career;Cefepime;Ceftriaxone;Cellular Structures;Central Nervous System;Central Nervous System Agents;Central Nervous System Diseases;Central Nervous System Infections;Cerebrospinal Fluid;Chemicals;Child;Childhood;Clinical;Clinical Research;Clinical Trials;Concentration measurement;cytokine;Data;design;Dexmedetomidine;Disease;Disease Management;Dose;drug efficacy;Drug Exposure;Drug Kinetics;Drug Modelings;Drug Targeting;Engineering;Epilepsy;experience;Faculty;Funding;Future;Human;improved;In Vitro;in vitro Model;Infection;Inflammatory;Infrastructure;inhibitor;insight;Knowledge;Levetiracetam;lipophilicity;Literature;mathematical model;Measurement;Measures;Membrane Transport Proteins;Meningitis;Mental Depression;Mentors;Mentorship;Methods;Minimal Risk Study;Modeling;models and simulation;Molecular Structure;Nervous System Disorder;Outcome;Pathway interactions;Patients;Pediatric Hospitals;Permeability;Pharmaceutical Preparations;pharmacokinetic model;pharmacometrics;Pharmacotherapy;Phase;Physiological;Physiology;Plasma;predictive modeling;Principal Investigator;Process;Property;prospective;Public Health;Qualifying;Recording of previous events;Regimen;Research;Research Design;Research Personnel;Resources;Risk;Safety;Sampling;simulation;skills;specific biomarkers;Spinal Puncture;System;Therapeutic;Time;Tissues;tool;Toxic effect;Training;Treatment Failure;Universities;Utah;Vancomycin;Ventricular;virtual;Work

PROJECT_TITLE: Optimal Dosing of CNS Drugs for Children

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LOMA LINDA

ORG_NAME: VA LOMA LINDA HEALTHCARE SYSTEM

PHR: Since 2000, at least 250,000 U.S. Service members have experienced a blast-related mild traumatic brain injury. A retrospective analysis of over 100,000 post-9/11 Veterans shows that blast injury more than doubles the risk of a diagnosed auditory problem. Many blast-exposed Veterans experience “functional hearing difficulties” (FHDs): problems in challenging listening environments despite clinically normal hearing as measured by the pure-tone audiogram. VA audiologists have begun using low-gain hearing aids to treat FHDs, but there are no concrete guidelines for this application given standard procedures rely on the pure-tone audiogram. This study proposes a data-driven approach called speech-based audiometry (SBA), which optimizes hearing aid gains from a patient’s responses to speech stimuli in aided conditions. A first study will quantify the behavioral and neurophysiological benefits of low-gain hearing aids programmed conventionally or with SBA among Veterans with FHDs. A second study will explore applications of SBA in current hearing aid users with different loss profiles.

PI_NAMEs: VENEZIA, JONATHAN HENRY (contact)

PROJECT_TERMS: Acclimatization;Address;Age;Aging;Algorithms;Auditory area;Auditory system;Behavioral;behavioral outcome;blast exposure;Blast Injuries;brain based;Brain region;Clinical;Clinical Trials;Cognitive;comparative efficacy;Data;design;Diagnosis;Digit structure;Environment;experience;Functional Magnetic Resonance Imaging;Future;Goals;Guidelines;Hearing;Hearing Aids;hearing impairment;Hearing problem;Hearing Tests;improved;individual variation;instrument;Intuition;K-Series Research Career Programs;Laboratories;Linear Regressions;Machine Learning;Measures;Methods;mild traumatic brain injury;neurophysiology;Noise;noise exposure;normal hearing;novel;open label;Outcome;Outcome Measure;Participant;participant enrollment;patient response;Patient Self-Report;Patients;Performance;Peripheral;Phase I Clinical Trials;post 9/11;Prefrontal Cortex;Procedures;programs;Protocols documentation;Reaction Time;Recording of previous events;recruit;Reporting;Research;response;Risk;Scanning;Sensorineural Hearing Loss;service member;Signal Transduction;Speech;speech in noise;Speech Intelligibility;speech processing;Statistical Models;Stimulus;Structure;Subgroup;Surveys;Testing;Time;Trauma;Veterans;white matter;Work

PROJECT_TITLE: Benefits of speech-based audiometry and low-gain hearing aids for blast-exposed Veterans

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Black individuals experience two-to-four times higher rates of end-stage kidney disease that their White counterparts. Structural racism, racialized and discriminatory policies and practices promoted through major social systems such as housing and health care, may act as an additional third hit exacerbating the risk of poor kidney health outcomes, above and beyond its impact on co-morbid conditions. This proposal will engage a stakeholder board to help characterize and measure the effects of structural racism on people with APOL1 risks and develop a patient-centered intervention to mitigate the effects of structural racism on adverse kidney health outcomes.

PI_NAMEs: MOHOTTIGE, DINUSHIKA  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acceleration;Address;Advocate;Albuminuria;Alleles;APOL1 gene;Award;black patient;Black Populations;Black race;career;Caregivers;Caring;Chronic Kidney Failure;Clinical;clinical risk;Clinical Trials Design;cohort;Cohort Studies;Collaborations;Communities;comorbidity;Complex;COVID-19;Cross-Sectional Studies;Dedications;design;Development;Diabetes Mellitus;Dimensions;Disease Progression;disorder risk;End stage renal failure;Environment;Epidemiology;Equity;Evaluation;experience;feasibility testing;Focus Groups;Foundations;Funding;Future;Goals;Harm Reduction;Health;health disparity;Healthcare;Heart;high risk;HIV;Housing;Hypertension;implementation intervention;improved;Individual;Intervention;intervention mapping;Interview;Kidney;Kidney Diseases;Kidney Failure;Legal;Link;Lived experience;longitudinal analysis;Longitudinal Studies;Measures;Mentors;Mentorship;Methods;multidisciplinary;multilevel analysis;Outcome;Participant;patient engagement;patient oriented;Patient Outcomes Assessments;Patients;Penetrance;Persons;Pharmacy facility;pilot test;Policies;Pollution;Poverty;Prevalence;primary care clinician;Race;racial bias;racial disparity;recruit;Research;Research Personnel;Resources;Risk;Risk Factors;risk variant;Science;skills;social;Social Environment;Structural Racism;Structure;System;Techniques;Testing;therapy design;Training;Waiting Lists

PROJECT_TITLE: Structural Racism as a "Third hit" on kidney outcomes of Black individuals with APOL1 risk alleles

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Vaginal childbirth is a leading risk factor for morbid conditions that affect a quarter of U.S. women, referred to collectively as pelvic floor disorders. Vaginal birth injury to the pelvic floor muscles is the posited link between vaginal delivery and pelvic floor disorders, thus, this proposal will determine how pregnancy-induced remodeling prepares these skeletal muscles for the mechanically demanding task of vaginal childbirth. Multiscale computational and experimental methods will elucidate the hormonal and mechanical drivers of pelvic floor muscle alterations in pregnacy that impact whole muscle active and passive mechanical function.

PI_NAMEs: ROUTZONG, MEGAN  (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: Affect;Area;arm;Automobile Driving;Biological Models;Biomechanics;Birth;Birth trauma;Calibration;cell type;Cells;Cesarean section;Cessation of life;Childbirth;Clinical;Collagen;Computing Methodologies;cost;Coupled;Coupling;Cultured Cells;Data;Deposition;Development;Dimensions;Elements;Epidemiology;Estrogens;experimental arm;Extracellular Matrix;Female;Fibroblasts;Fluorescence;Functional disorder;Gonadal Steroid Hormones;Growth;Harvest;Histology;Hormonal;Hormones;Human;improved;in vivo;indexing;Individual;Influentials;Injury;Intervention;Knowledge acquisition;Late pregnancy;Length;Link;Literature;Maps;Measures;mechanical behavior;mechanical properties;Mechanics;Methods;Microscopy;Modeling;multi-scale modeling;Muscle;Muscle Fibers;muscle progenitor cell;muscular structure;network models;Output;Patients;Pelvic Floor Disorders;Pelvic Floor Muscle;Pelvis;personalized intervention;Phase;Placenta Diseases;Play;Postpartum Period;predictive modeling;Pregnancy;prevent;Primary Cell Cultures;Process;progenitor;Progesterone;Property;Proxy;Quality of life;Radial;Rattus;regeneration function;Risk;Risk Factors;risk stratification;Role;Sampling;Shapes;Signal Pathway;Signal Transduction;simulation;Skeletal Muscle;soft tissue;Stains;Stress;Stretching;Structure;Testing;tool;Translating;translational study;Vagina;Vaginal delivery procedure;Weight-Bearing state;Woman

PROJECT_TITLE: Multiscale Experimental and Computational Methods to Characterize Hormonal and Mechanical Contributions to Pregnancy-Induced Remodeling of Skeletal Muscle

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN DIEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative Significant disparities in cardiovascular diseases persist among racial and ethnic minorities. There is an urgent need for effective and sustainable interventions to improve the cardiovascular health of diverse communities. The objectives of this K24 grant are to allocate protected time for Dr. Elva Arredondo to conduct cardiovascular health equity research and expedite the implementation of evidence based programs in real-world settings, including communities. Additionally, the K24 aims to provide training and mentorship to trainees seeking to conduct community-engaged implementation research to reduce cardiovascular health disparities.

PI_NAMEs: ARREDONDO, ELVA M (contact)

PROGRAM_OFFICER_NAME: KHAN, SHAHNAZ

PROJECT_TERMS: Acceleration;Address;Administrative Supplement;Award;Behavior Therapy;Behavioral;Biomedical Research;Body mass index;Cardiovascular Diseases;cardiovascular health;career;career development;Chronic Disease;Church;Clinical Trials;Communities;community engaged research;Community Health Aides;community intervention;community organizations;community setting;cost;cost effective;Data;Dedications;Development;disease disparity;Disparity;distrust;Educational Intervention;Effectiveness;Ensure;ethnic minority;Evidence based intervention;Evidence based program;exercise intervention;Faith;Faith-based organization;Feedback;follow-up;Fostering;Funding;Goals;Grant;Health;health disparity;health equity;health equity promotion;Health equity research;Health Promotion;Human;implementation outcomes;implementation research;implementation strategy;improved;Incubators;Infrastructure;innovation;Institution;Intervention;Investments;Knowledge;Latina Population;Latino;Lead;Marketing;member;Mentors;Mentorship;Methods;minority trainee;motivational enhancement therapy;National Heart, Lung, and Blood Institute;novel;Outcome;Outcome Study;Parents;patient oriented;patient oriented research;Personal Satisfaction;Physical activity;premature;Prevention program;professor;Program Sustainability;programs;Psychology;racial minority;Randomized;Randomized, Controlled Trials;Readiness;Reduce health disparities;Research;Research Project Grants;Research Support;Resources;scale up;Science;skills;Sustainable Development;systematic review;Telephone;Testing;Time;Training;Translations;Underrepresented Minority;Underrepresented Populations;underserved community;Underserved Population;United States National Institutes of Health;Universities;wasting;Work

PROJECT_TITLE: Mentoring trainees from diverse backgrounds in community engaged research to promote cardiovascular health

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Electronic Nicotine Delivery Systems;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Coronary heart disease remains the number one killer in the United States and other developed countries. There is a great need to understand the mechanisms leading to coronary heart disease, particularly in response to environmental risk factors. This study will exploit our recent findings from an NHLBI K08-funded study to understand the role of maladaptive protein aggregation in the vascular wall and coronary heart disease.

PI_NAMEs: KIM, JUYONG BRIAN (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Address;Affect;Aging;AHR gene;Air Pollution;Animal Model;Apoptotic;Arterial Fatty Streak;Arteries;Aryl Hydrocarbon Receptor;Atherosclerosis;Automobile Driving;Autophagocytosis;Award;Blood Vessels;Cause of Death;cell type;Cells;Cessation of life;cigarette smoke;Coronary artery;Coronary heart disease;cytokine;Developed Countries;Development;Disease;disease phenotype;Disease Progression;Electronic cigarette;endoplasmic reticulum stress;Environment;Environmental Risk Factor;environmental stressor;Epigenetic Process;Exposure to;Foundations;Fractionation;Funding;Future;Genetic;Genetic Diseases;Genetic Transcription;Grant;Heat-Shock Response;Human;Hyperlipidemia;In Vitro;Inflammation;Inflammatory;inhibitor;K-Series Research Career Programs;knock-down;Knowledge;Lamin Type A;Lead;Lesion;Mass Spectrum Analysis;Mediating;misfolded protein;mortality;National Heart, Lung, and Blood Institute;new therapeutic target;novel;overexpression;Oxidative Stress;Oxidative Stress Induction;oxidized lipid;Pathway interactions;Phenotype;Play;premature;Process;Progeria;protein aggregation;protein degradation;protein misfolding;Proteins;proteostasis;proteotoxicity;Protocols documentation;Research;Resolution;response;Risk;Risk Factors;Role;Signal Pathway;Smooth Muscle;Smooth Muscle Myocytes;Stimulus;Stress;stressor;Syndrome;Tissues;Tobacco;Tobacco smoke;Toxic Environmental Substances;Tunicamycin;United States;vascular factor;Vascular Smooth Muscle;Work

PROJECT_TITLE: Unfolding the role of misfolded proteins in smooth muscle cell phenotypic modulation and atherosclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Z (J2)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative This research program aims to use innovative technologies (chemical proteomic and prime editing) to discover and functionally characterize new sites for drug action in oncogenic proteins. We have already identified novel druggable proteins involved in RNA processing in cancer cells and our platform will reveal more druggable cancer dependencies for therapeutic development.

PI_NAMEs: LI, HAOXIN  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Acceleration;activity-based protein profiling;Address;Affect;anti-cancer research;Arginine;Award;base editing;base editor;Binding;Biochemistry;Biology;Cancer Biology;cancer cell;Cancer Cell Growth;cancer therapy;Categories;Cell Proliferation;chemical genetics;Chemicals;Chemistry;Collaborations;Communication;CRISPR screen;Cysteine;Data;Dependence;Development;Development Plans;DNA sequencing;drug action;drug development;Event;Generations;Genes;Genetic;genome editing;genome-wide;improved;inhibitor;innovation;innovative technologies;Institution;Laboratories;Learning;Ligand Binding;Ligands;Malignant Neoplasms;Maps;Medical Oncologist;Mentors;Merkel cell carcinoma;Methods;Missense Mutation;Modeling;Molecular;next generation;novel;nuclease;Nucleotides;Oncogenic;Pathway interactions;pharmacologic;Phase;Pilot Projects;precision medicine;prime editing;programs;protein function;Proteins;Proteome;Proteomics;Research;Research Institute;Resolution;RNA;RNA Binding;RNA Processing;RNA Splicing;RNA-Binding Proteins;Site;skills;small molecule;Spliceosomes;Tail;Techniques;technological innovation;Technology;Telomerase;Testing;Therapeutic;therapeutic development;therapeutic target;tool;Training;transcriptome;Tyrosine;Universities;Untranslated RNA;Writing

PROJECT_TITLE: Discovering and Characterizing Druggable Cysteines in Cancer Dependency Proteins

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Retaining a vital biomedical research workforce is critical for facilitating the scientific advancements necessary to improve human health. The Training to Enhance Researcher Resilience and Adaptability (TERRA) project will benefit public health through integrating emerging well-being scholarship with educational practices for enhanced self-efficacy, providing novel, freely available training resources to better support biomedical researcher well-being, adaptability, and resilience. By addressing well-being gaps in the current biomedical research environment, TERRA will provide new tools for retaining this critically-important workforce.

PI_NAMEs: SCHWARTZ, RACHEL  (contact);SINSKEY, JINA LEE

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Advisory Committees;Advocacy;Affect;Area;Attention;Basic Science;Biomedical Research;burnout;career;Climate;Clinical;Clinical Medicine;Clinical Sciences;Communities;Consultations;Control Groups;Data;Development;Doctor of Philosophy;Education;Educational Assessment;Educational Models;Emotional;Environment;Equity;Evaluation;evidence base;experience;Face;Faculty;faculty mentor;Female;flipped classroom;Focus Groups;Fostering;Funding;Gender;Goals;Graduate Education;group intervention;Health;Health Services Research;Human;improved;Infrastructure;Institution;Intervention;Interview;Investigation;Leadership;Learning;Life;Measures;Medical Education;medical specialties;member;Mentors;Mentorship;Methods;mid-career faculty;Modeling;Motivation;Needs Assessment;novel;Occupations;Participant;peer;Personal Satisfaction;Phase;pilot test;Population;Postdoctoral Fellow;pre-doctoral;pressure;Process;Productivity;programs;promote resilience;Public Health;randomized, controlled study;Research;Research Design;Research Personnel;resilience;Resources;Review Literature;Scholarship;Scientific Advances and Accomplishments;Scientist;Self Efficacy;Series;Students;success;Surveys;Talents;Techniques;tool;Training;Training Activity;Training Programs;United States National Institutes of Health;Waiting Lists;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-U (RW)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Approximately 1 in every 70 people are transfused each year. Over time, the immune system of patients can recognize donor blood as foreign, making it harder and harder to find units of blood that can be transfused. This project attempts to understand how transfusion recipients respond to donor blood to help guide the development of ways to prevent this problem.

PI_NAMEs: ZIMRING, JAMES C. (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Alloantigen;Alloimmunization;Amino Acids;Animal Model;Antibody Response;Antigens;Biology;Blood;Blood donor;Characteristics;Chromosome 19;Chronic;Clinical;Cytomegalovirus Infections;Data;Development;Disease;Distal;Environmental Risk Factor;Erythrocyte Transfusion;Erythrocytes;Event;experimental study;Exploratory/Developmental Grant;Family;Family member;fetal;Fetus;Frequencies;Genes;Genetic;Genetic Polymorphism;Genetic Variation;genome wide association study;genome-wide;Grant;Healthcare Systems;Hospitals;Human;Immune response;Immune system;Immunize;Immunologics;immunoregulation;Inbred Strains Mice;Individual;Infection;Inpatients;Interferon alpha;Interferons;Intervention;Isoantibodies;Knockout Mice;Lod Score;member;Minority;Modeling;Monitor;Morbidity - disease rate;mortality;mouse model;Murid herpesvirus 1;Mus;Newborn Infant;novel;Pathway interactions;Patients;Persons;Phenotype;Population;prevent;Property;Proteins;Quantitative Trait Loci;receptor;Receptor Signaling;Regulation;Reporting;Research Priority;responders and non-responders;response;Risk Factors;RNA Viruses;Role;Running;Series;Signal Transduction;Structure;System;Testing;Time;trait;Transfusion;Translating;translational study;Vaccination;Viral Physiology;Viremia;Virus Diseases;Work

PROJECT_TITLE: Role of IFITs in RBC Alloimmunization

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Accurate, timely surveillance approaches are needed in the U.S. to understand the incidence and prevalence of diabetes among young adults that can distinguish by type, and generate estimates by race/ethnicity, age group, sex and geographic regions. Continuous monitoring of the young adult population will identify disproportionately impacted subpopulations and aide in the development of primary, secondary and tertiary diabetes prevention and management strategies.

PI_NAMEs: CRUME, TESSA L (contact);DABELEA, DANA

PROJECT_TITLE: DP20-001 Surveillance of Diabetes in Young Adults between 18-45 Years of Age (DiCAYA) - Component B


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative There is a high prevalence of post-traumatic stress disorder (PTSD) and chronic lower respiratory symptoms among community members affected by the September 11, 2001 terrorist attack on the World Trade Center (WTC) towers (“Survivors”). Despite widely reported cognitive impairments among WTC Responders, there is a lack of information about cognitive status among WTC Survivors and there is a lack of knowledge about the association between WTC exposures, chronic PTSD, severe lung disorders, cognitive status, and cognitive decline over time. To improve diagnosis and treatment and to identify the biological underpinning of the health disorders, in this project we propose to investigate the biological mechanisms linking WTC exposures, comorbid PTSD and severe lung disorders, with cognitive function or decline by assessing the effect of inflammation and neurodegeneration biomarkers in blood as mediators of WTC exposures and risk of cognitive abnormality and as possible modifiable targets for interventions.

PI_NAMEs: REIBMAN, JOAN ;SHAO, YONGZHAO  (contact);WISNIEWSKI, THOMAS M

PROJECT_TITLE: Cognitive decline among WTC survivors with chronic mental and physical disorders


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Characterizing the totality of WTC exposure—both psychological and chemical—has been challenging, particularly among pregnant women and children, which has limited our ability to identify WTC-related health effects. New advances in high resolution gas chromatography can characterize WTC-related exposure and biological response to exposure in ways that were previously impossible. This study uses novel metabolomic and exposomic methods to characterize WTC exposure and the effects of WTC exposure among those who were exposed in utero or as children, two sensitive windows of development.

PI_NAMEs: HERBSTMAN, JULIE BETH (contact);TRASANDE, LEONARDO

PROJECT_TITLE: Exposomic Approach to Identifying WTC Exposures and Effects in Survivor Youth.


FUNDING_MECHANISM: OTHERS

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: PROJECT NARRATIVE: Cannabis consumption for recreational and medicinal purposes has increased worldwide over the last decade. Emerging evidence suggests that the kidney expresses cannabinoid receptors and produces endogenous cannabinoids. Activation of these receptors acutely increases urine output with variable effects on sodium and potassium excretion in mice, rats, and rabbits. A body of very few studies in humans suggest that cannabinoids can act as diuretics to promote sodium bicarbonate excretion. Given the emerging evidence suggesting that cannabinoids regulate urine output and ion transport in the kidney, and rapidly increasing widespread usage of cannabis, the proposed investigation promises to elucidate the functional role of cannabinoids in the kidney epithelial cells that regulate total body electrolyte, acid/base and fluid homeostasis, and will allow us to identify new therapeutic agents for the treatment of disorders common among people living with kidney disease such as hypertension, volume overload, metabolic acidosis, and hyponatremia.

PI_NAMEs: REIN, JOSHUA L (contact)

PROJECT_TERMS: 2-arachidonylglycerol;absorption;Acids;Acute;Address;Adult;Affinity;aged;Agonist;Aldosterone;Alkalies;American;anandamide;Animal Model;Apical;Applications Grants;Arachidonic Acids;autocrine;base;Bicarbonates;Biological;Board Certification;cannabinoid receptor;Cannabinoids;Cannabis;career;career development;Cell Physiology;Cell Separation;Cells;Cellular biology;Certification;Chronic Disease;Chronic Kidney Failure;CNR1 gene;CNR2 gene;Consumption;Coupled;cyclooxygenase 2;Development;Development Plans;Dinoprostone;Disease;Distal;Diuresis;Diuretics;Duct (organ) structure;Educational workshop;Electrolytes;Electrophysiology (science);Elements;Endocannabinoids;endogenous cannabinoid system;Environment;Enzymes;Equilibrium;Esters;Excretory function;Exhibits;Exposure to;fatty acid amide hydrolase;fetal;Fluid Balance;Genetic;Glucose;GLUT-2 protein;Goals;GTP-Binding Proteins;Homeostasis;Human;human disease;Hypertension;Hyponatremia;Impairment;In Vitro;Ingestion;inhibitor;insight;Intercalated Cell;Investigation;Ion Transport;K ATPase;K-Series Research Career Programs;Kidney;Kidney Diseases;kidney epithelial cell;kidney fibrosis;Knockout Mice;Knowledge;Leadership;Legal;Ligands;Limb structure;Lipid Biochemistry;Lipids;lipoprotein lipase;Liquid Chromatography;marijuana use;Measures;Mediating;medical schools;Medicine;Mentors;Mentorship;Metabolic acidosis;Metabolic Pathway;Microdissection;Microscopy;Molecular;Monoacylglycerol Lipases;mouse model;Mus;NAPE-PLD;Nephrons;novel;novel therapeutics;Oryctolagus cuniculus;Osmosis;Output;paracrine;Paracrine Communication;Pathway interactions;Perfusion;Persons;pharmacologic;Pharmacology;Physiological;Physiology;phytocannabinoid;Play;Population;Potassium;preclinical study;Property;Proteins;Proteinuria;Rattus;Receptor Activation;Receptor Signaling;Records;Recovery;Recreation;Recreational Drugs;Regulation;Renal Blood Flow;renal tubular transport;Reporting;Research;response;Rodent;Role;Signal Transduction;skills;Sodium;Sodium Bicarbonate;Sodium Chloride;Sorting;Specialist;success;tandem mass spectrometry;Testing;Therapeutic;Therapeutic Agents;Thick;Time;Training;Transcript;Transgenic Mice;Translating;Tubular formation;urinary;Urine;Veterans;volume hypertension;Water

PROJECT_TITLE: The regulation of renal tubular transport by cannabinoid receptor type 1 (CB1R) and its endogenous lipid ligands


ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Narrative We anticipate that this study will generate novel insights into the mechanisms whereby the integrin linked kinase (ILK), Pinch and parvin (IPP) complex regulates the response of kidney tubules to injury and fibrosis. We will also test the ability of novel ILK inhibitors to decrease the amount of injury and fibrosis in mouse models of kidney injury. This knowledge may result in novel therapeutics being developed to protect the kidney from chronic injury.

PI_NAMEs: ZENT, ROY  (contact)

PROJECT_TERMS: Actins;Affect;Amino Acids;Binding;Binding Proteins;Bundling;Cell Adhesion;Cell Physiology;Cell Polarity;Cell Proliferation;Chronic;Chronic Kidney Failure;cofilin;Complex;Cytoplasmic Protein;Cytoplasmic Tail;Cytoskeleton;Data;Defect;depolymerization;Development;Ductal Epithelial Cell;ECM receptor;effective therapy;Embryonic Development;Epithelial Cells;F-Actin;Family;Fibrosis;Guanosine Triphosphate Phosphohydrolases;Homeostasis;improved;Injury;injury recovery;Injury to Kidney;insight;Integrin Binding;integrin-linked kinase;Integrins;interest;Kidney;Kidney Diseases;kidney fibrosis;kidney repair;kinase inhibitor;Knowledge;LIMK1 gene;mechanical signal;Mediating;Membrane;Microfilaments;migration;Mission;Modality;Modeling;mouse model;Mus;mutant;Mutation;nephrogenesis;novel;novel therapeutics;Obstruction;Pathway interactions;Phenotype;prevent;Process;Proliferating;protein complex;receptor;Recovery;Regulation;Renal tubule structure;repaired;response;response to injury;rho;rho GTP-Binding Proteins;Role;scaffold;Scaffolding Protein;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;System;Testing;Tissues;transmission process;Tubular formation;Veterans;Wild Type Mouse

PROJECT_TITLE: lntegrin binding proteins and the kidney


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: MAPUTO

ORG_COUNTRY: MOZAMBIQUE

ORG_FIPS: MZ

ORG_NAME: FUNDACAO MANHICA

PHR: This project aims to disentangle the role of host immune resistance and disease tolerance in afebrile malaria infections, with the goal of guiding context-adapted tactics to target this hidden reservoir, as well as to develop new approaches to clear malaria infection and reduce its severity through host-directed therapies.

PI_NAMEs: AIDE, PEDRO  (contact);MAYOR, ALFREDO

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Adult;Affect;Antibodies;Antibody Response;Antibody-mediated protection;Antigens;Biological;Biological Assay;Biological Factors;Biomass;Child;Chronic;chronic infection;Clinical;cohort;Consensus;Cytometry;Data;density;Detection;Development;Diagnostic tests;Disease;Down-Regulation;Epidemiology;Equilibrium;Erythrocyte Membrane;Erythrocytes;evidence base;Failure;Fever;Flow Cytometry;follow-up;Future;Gene Expression Profile;Gene Family;Genes;Genetic Transcription;Genotype;Goals;Health;Heterogeneity;Homeostasis;Host resistance;Host-Parasite Relations;Immune;Immune Evasion;immune resistance;Immune response;Immune System Diseases;Immunity;Incidence;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Investigation;Knowledge;Leukocytes;Malaria;malaria infection;Mass Spectrum Analysis;Measurement;Mediating;Metabolic;Metabolic Pathway;Microscopy;Molecular;Molecular Biology;Molecular Immunology;Mozambique;next generation sequencing;novel strategies;Outcome;Parasitemia;Parasites;Parasitology;pathogen;Pathogenicity;Pathology;Pathway interactions;Plasmodium falciparum;Plasmodium falciparum erythrocyte membrane protein 1;Population;preservation;pressure;Prevalence;Prospective Studies;rapid detection;Regulation;repository;Research;Role;Sampling;Severities;Source;Surface;Surface Antigens;Symptoms;Testing;Time;Tissues;tool;transmission process;Up-Regulation;Variant;Work;γδ T cells

PROJECT_TITLE: Unravelling disease tolerance and host resistance in afebrile P. falciparum infections: a prospective study in Mozambican adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(55)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Our mission within the UA COM-T, MD-PhD Program is to develop a diverse pool of highly trained physician- scientists who have the aptitude to utilize clinical experience in developing biomedical hypotheses that integrate the research skills learned in our program. The State of Arizona is in need of Physician-Scientists that represent their diverse backgrounds.

PI_NAMEs: FANTRY, GEORGE T.;MERCHANT, JUANITA L.;VANDERAH, TODD W (contact);WERTHEIM, JASON A

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Future;Physicians;Scientist;Training

PROJECT_TITLE: Interdisciplinary Training of Future Physician Scientists

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cervical Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Cervical cancer is a life-threatening pathology highly associated with human papilloma virus (HPV) infection that disproportionally affects low- and middle- income countries. A major barrier in implementing and sustaining screening programs for cervical cancer in low-resource countries is the lack of an affordable and effective screening test that can provide HPV results at the point-of-care. This proposal will develop and evaluate a novel DNA-based approach that combines isothermal recombinase polymerase amplification with fluorescent quantification in an accurate and low-cost test, which could improve access to cervical cancer screening and significantly decrease mortality due to the disease.

PI_NAMEs: MAKER, YAJUR NAMAN (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acetic Acids;Affect;Africa;Biological Specimen Banks;Buffers;burden of illness;Cell Line;Cellular Phone;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cessation of life;Clinical;Collection;Communicable Diseases;Computer software;cost;Country;Cytology;Cytolysis;design;Detection;detection limit;detection platform;Development;Diagnosis;Disease;DNA;DNA amplification;Doctor of Philosophy;Educational process of instructing;efficacy testing;Ensure;Environment;Equipment;experience;Fluorescence;fluorescence imaging;Freeze Drying;Genomic DNA;Goals;Heating;Hela Cells;HIV-1;HPV negative;HPV positive;HPV screening;HPV-High Risk;Human papilloma virus infection;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;Human Resources;Image;Image Analysis;imager;imaging platform;imaging system;Improve Access;improved;Infrastructure;instrument;isothermal amplification;Life;low and middle-income countries;Malignant neoplasm of cervix uteri;medically underserved;Membrane;Mentorship;Microfluidic Microchips;Microscope;Monitor;Morbidity - disease rate;mortality;Mozambique;multidisciplinary;new technology;novel;Nucleic Acid Amplification Tests;Nucleic Acids;Optics;Pap smear;Paper;Pathology;Patients;Performance;Pilot Projects;Plastics;point of care;Polymerase;Preventive measure;Process;Reaction;Reagent;recombinase;Recommendation;Reporting;Resource-limited setting;Resources;Risk;Sampling;screening;screening program;Site;Specificity;Specimen;success;synthetic construct;System;Technology;Testing;Time;Training;Translating;Translational Research;Translations;Tube;two-dimensional;underserved area;underserved community;Update;usability;Visual;Woman;Work;World Health Organization

PROJECT_TITLE: Low-cost integrated nucleic acid amplification testing platform for cervical cancer screening in low- and middle-income countries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Project Narrative Childhood ependymoma (EPN) is an aggressive malignant brain tumor with high mortality. Previously we implicated LDOC1 silencing in this tumor’s biology. This proposal examines the mechanism of how LDOC1 silencing, via non-canonical NF-B, drives EPN tumor cell biology.

PI_NAMEs: FOREMAN, NICHOLAS K (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Address;Affect;Automobile Driving;Biological Assay;Biology;Brain Neoplasms;Brain Stem;Cancer Etiology;Cell Line;Cell Separation;Cells;Cessation of life;chemotherapy;Child;Childhood Brain Neoplasm;childhood cancer mortality;Childhood Ependymoma;ChIP-seq;Chromatin;chromatin remodeling;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Complement;Data;design;Disease;DNA Methylation;Down-Regulation;driver mutation;effective therapy;Ependymoma;Epigenetic Process;epigenetic regulation;epigenetic silencing;Excision;experience;Gene Silencing;Genes;Genetic Transcription;Genomics;high risk;histone modification;In Vitro;in vivo;insight;Interleukin-6;Invaded;Investigation;irradiation;Knock-out;Malignant neoplasm of brain;Malignant neoplasm of prostate;Malignant Neoplasms;Medulloblastoma;Mesenchymal;methylomics;migration;Molecular;molecular sequence database;Morbidity - disease rate;mortality;Neoplasm Metastasis;neoplastic cell;NF-kappa B;Non-Malignant;novel;Operative Surgical Procedures;Outcome;overexpression;Pathway interactions;Patients;Pediatric Neoplasm;Phenotype;Posterior Fossa;prevent;Prior Therapy;Radiation;Recurrence;Regulation;RELA gene;Relapse;Research;Resistance;Role;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule;Subgroup;Supratentorial;therapeutic target;Time;transcription factor;transcriptome;tumor;Tumor Biology;Tumor Cell Biology;Tumor Subtype;Undifferentiated;Up-Regulation;Work

PROJECT_TITLE: Epigenetic regulation of LDOC1 drives tumor biology in high risk ependymoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Services;Heart Disease;Networking and Information Technology R&D (NITRD);Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Telehealth

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE While transcatheter heart valve interventions (THVIs) offer a less invasive option to treat clinically significant heart valve disease in older adults, over one-half of patients are dead, have poor quality of life, and/or are hospitalized 1 year after a THVI. While cardiac rehabilitation is effective at mitigating these poor outcomes, only 25% of patients participate in center-based cardiac rehabilitation in the year after their THVI and numerous barriers to participation exist. We propose a multicenter randomized controlled trial enrolling patients undergoing a THVI to test whether and how a home-based cardiac rehabilitation intervention that addresses key target health behaviors, leverages mobile health technology (e.g. Apple Watch to encourage physical activity and deliver reminders on healthy living), prescribes exercises to build strength and balance, and incorporates habit formation strategies to promote sustained behavior change will improve physical activity, functional capacity, and quality of life and decrease clinical events.

PI_NAMEs: LINDMAN, BRIAN RICHARD (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Activities of Daily Living;Address;aging population;Aorta;aortic valve;Apple watch;behavior change;Behavioral Mechanisms;Behavioral Sciences;beneficiary;Cardiac rehabilitation;Cardiac Surgery procedures;Cardiovascular Diseases;care outcomes;Cessation of life;Clinical;clinically relevant;clinically significant;comparison control;Complement;Counseling;design;digital tool;Disablement;Disease;efficacy/implementation trial;Equilibrium;Event;Exercise;exercise physiologist;Exercise Physiology;exercise prescription;exercise regimen;fitbit;Future;Geriatrics;Goals;group intervention;Habits;Hand;Health behavior;Health Technology;Heart Valve Diseases;Heart Valves;Home;home test;hospital readmission;Hospitalization;improved;Individual;infancy;innovation;Intervention;Measures;Mediator;Medicare;mHealth;mhealth interventions;Mobile Health Application;Monitor;Morbidity - disease rate;mortality;multidisciplinary;novel;older adult;Operative Surgical Procedures;Outcome;Participant;participant enrollment;Patient Participation;patient population;Patient-Focused Outcomes;Patients;Physical activity;Pilot Projects;pilot trial;Prevalence;primary endpoint;Procedures;programs;Quality of life;Randomized;Randomized, Controlled Trials;Recovery;Registries;repaired;Research Design;Running;Safety;secondary endpoint;Skilled Nursing Facilities;Social support;Specific qualifier value;Subgroup;success;Testing;therapy design;Translations;trial enrollment;video chat;virtual intervention;Visit;Walking;Work

PROJECT_TITLE: Home-based cardiac rehabilitation using a novel mobile health exercise regimen following transcatheter heart valve interventions (HOME RUN HITTER)

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE Several studies have explored the possibility to clear tau pathology in animal models of Alzheimer’s disease (AD) using immunotherapy. Unfortunately, the therapeutic potential of antibodies to treat neurodegenerative diseases is limited due to the difficulty of crossing the blood-brain barrier (BBB) and reaching target molecules in the brain. The objective of this study is to investigate the effectiveness of engineered tau antibodies as treatment for tau pathology in transgenic animal models of AD, defining the mechanism of action of immunotherapy, and exploring a cost-effective therapeutic to translate into humans.

PI_NAMEs: D'ABRAMO, CRISTINA  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Adopted;Adult;Adverse event;Affinity;Alzheimer's Disease;Alzheimer's disease model;Animal Model;Antibodies;Antigen-Antibody Complex;Articulation;behavioral outcome;behavioral phenotyping;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Cells;Characteristics;Clinical Trials;Cognitive;Complex;cost;cost effective;Data;Dependovirus;design;Development;Disease Progression;Dose;Effectiveness;efficacy evaluation;Engineering;Epitopes;Excision;extracellular;Extracellular Protein;Fc Immunoglobulins;Functional disorder;Goals;Hippocampus;Human;hyperphosphorylated tau;Immunoglobulin Fragments;Immunotherapy;Impaired cognition;In Vitro;Inflammation;Inflammatory;Inflammatory Response;Injections;Intramuscular;Intramuscular Injections;Laboratories;Light;Literature;Mediating;Microglia;Modeling;Molecular Conformation;Monoclonal Antibodies;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;novel therapeutic intervention;Parents;Passive Immunization;Passive Immunotherapy;Pathologic;Pathology;Penetration;Peripheral;pharmacologic;Phosphorylation;preservation;prevent;Prevention;Process;Protocols documentation;Publishing;Reaction;Recombinants;response;Role;Route;Satellite Viruses;Source;Specificity;Striated Muscles;success;tau aggregation;tau conformation;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutically effective;Time;tool;Transgenic Animals;Transgenic Mice;Transgenic Organisms;Translating;translational approach;translational potential;Treatment Efficacy;uptake;vector;Viral Vector;Work

PROJECT_TITLE: Vectorized scFv antibodies to treat tau pathology in Alzheimer's disease: enhancing epitope targeting and delivery strategies

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG-R]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Inducing selective cell death in tumors lies at the core of ongoing research in pancreatic cancer. This proposal seeks to trigger pancreatic cancer cells for ferroptosis, a form of cell death independent from apoptosis and in culture, pancreatic cancer cells exhibit a native sensitivity to ferroptosis, while they exhibit mechanisms of intrinsic and adaptive resistance in vivo. This proposal will identify the factors that permit potent ferroptotic cell death in vitro, so as to deploy these in pancreatic tumors.

PI_NAMEs: GIZA, HEATHER MARIE (contact)

PROJECT_TERMS: Address;Affect;Alanine;Apoptosis;Biochemical;Cancer Biology;cancer cell;Cancer Etiology;Cell Culture Techniques;Cell Death;Cell Death Induction;cell type;Cells;Cessation of life;Chemoresistance;Clinic;Clinical Research;Collaborations;combat;Combination Drug Therapy;Culture Techniques;Cysteine;Cysteine Metabolism Pathway;Cystine;Cytolysis;density;Dependence;Diagnosis;Diffuse;Disease;Drops;Equilibrium;Event;Exhibits;experience;extracellular;Extracellular Matrix;Future;Genetic;Glutathione;Goals;Growth;Human Cell Line;Immune;Immunotherapy;In Vitro;in vivo;Individual;insight;interest;Iron;Link;Lipid Peroxides;Literature;Malignant neoplasm of pancreas;Malignant Neoplasms;Membrane;Metabolic;Metabolism;metabolomics;Michigan;Modeling;monolayer;mortality;Mouse Cell Line;Mus;Nature;novel therapeutic intervention;Osmolar Concentration;Osmosis;Osmotic Pressure;Oxidation-Reduction;Oxidative Stress;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;Pathway interactions;Patients;pharmacologic;pressure;programs;Proline;Publications;Regulation;Research;Resistance;Resources;response;Role;scale up;Scheme;Signal Transduction;spheroids;Stress;Survival Rate;System;Taurine;Testing;Therapeutic;therapeutic target;therapy resistant;three dimensional cell culture;treatment strategy;tumor;United States;Universities

PROJECT_TITLE: Defining cell intrinsic and extrinsic regulators of ferroptosis in pancreatic cancer


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The encoding of auditory and vestibular information begins in the hair cell, a specialized mechanosensitive cell that converts sound pressure waves and head orientation or movement into the release of the neurotransmitter glutamate. This grant aims to understand at a molecular level how hair cells control and regulate the release of neurotransmitter. In particular, this grant application aims at a better understanding of the role of Otoferlin, for which mutations lead to DFNB9 non-syndromic hereditary deafness.

PI_NAMEs: KARATEKIN, ERDEM ;ZENISEK, DAVID PAUL (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acceleration;Acute;Anatomy;Applications Grants;Auditory;Auditory Physiology;Auditory system;Binding;Binding Proteins;Biochemical;Biological Assay;Biological Models;Biophysical Process;C2 Domain;Calcium;Calcium Binding;Cell fusion;Cell membrane;Cells;Communication;Complex;Couples;Data;deafness;Dependence;Development;Docking;DYSF gene;effectiveness testing;Electric Capacitance;Electrophysiology (science);Embryo;Engineering;Exocytosis;experimental study;Family;genetic deafness;Genetic study;Glutamates;Grant;Hair Cells;Head;human disease;In Vitro;inhibitor;Injections;knock-down;Laboratories;lateral line;Lead;Learning;Length;Lipids;Measurement;Measures;Mediating;member;Membrane;Membrane Fusion;Mental Health;Modeling;Molecular;Molecular Biology;mosaic;Movement;Mus;mutant;Mutation;nanodisk;Nervous System Disorder;neuromast;Neurons;neurotransmitter release;novel;OTOF gene;Phenotype;Phospholipids;Physiology;plasmid DNA;pressure;presynaptic;Process;Property;protein complex;Proteins;Proteomics;Reaction;reconstitution;recruit;Recycling;ribbon synapse;Role;sensor;sensory stimulus;Signal Transduction;SNAP receptor;sound;Synapses;synaptic function;Synaptic Transmission;Synaptic Vesicles;synaptotagmin;syntaxin;target SNARE proteins;Techniques;Testing;Time;Total Internal Reflection Fluorescent;Toxin;Transgenic Organisms;Transmembrane Domain;Vesicle;vesicle-associated membrane protein;vesicular SNARE proteins;vestibular system;Visualization;Whole-Cell Recordings;Work;Zebrafish

PROJECT_TITLE: Mechanisms of the calcium-triggered neurotransmitter release machinery in hair cells

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN-M]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: Project Narrative Autophagy deregulation has been implicated in excessive inflammation and tumor cell proliferation. However, the molecular mechanisms underlying these changes have yet to be well-identified. By using a unique mouse model with inducible expression of a cancer-derived autophagy inhibitor, this application aims to elucidate the mechanisms by which intervention with autophagy suppressor exacerbates tumor-promoting inflammatory response and promotes age-related spontaneous cancers, thereby providing the molecular basis for the development of novel therapeutics for autophagy-related pathologies and diseases.

PI_NAMEs: LIANG, CHENGYU  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: 3-Dimensional;Address;Affect;age related;ApcMin/+ mice;Autophagocytosis;Autophagosome;beta catenin;Biochemistry;Biological Assay;Biological Process;Cancer Biology;Cell Death;Cell Physiology;Cell Proliferation;Cells;Cellular Stress;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Colitis;Colon;Complex;cytokine;Defect;Degradation Pathway;Detection;Development;Disease;DNA Repair;Dominant-Negative Mutation;effectiveness evaluation;Embryo;Endotoxins;Etiology;Frameshift Mutation;Functional disorder;Funding;gene function;Genes;Genetic;Grant;Homeostasis;Human;Impairment;in vitro Assay;in vivo;inducible gene expression;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibition of autophagy;inhibitor;innovation;insight;Intervention;Intestines;Investigation;Knock-in;Knowledge;Laboratories;Link;Lipids;Lysosomes;Malignant Neoplasms;Mediating;mitochondrial autophagy;Modeling;Molecular;mouse model;multidisciplinary;Mus;Mutagenesis;Mutant Strains Mice;Mutation;neoplastic cell;novel therapeutic intervention;novel therapeutics;Oncogenic;Organelles;Organoids;Pathologic;Pathology;Pathway interactions;Phosphotransferases;Physiological;Play;Predisposition;Process;Production;Productivity;Proteins;Qualifying;Recycling;Regulation;Research Personnel;Resistance;response;restoration;Role;Signal Transduction;single cell analysis;single molecule;Starvation;stem cell differentiation;Stimulus;Stress;System;Tissues;trafficking;treatment strategy;Tumor Promotion;tumorigenesis;ultraviolet irradiation;UV radiation-resistance associated gene;Validation;Work

PROJECT_TITLE: Autophagy-mediated defense against inflammation and cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE This proposal describes a new PhD training program, Genetic Approaches to Development and Disease (GADD) at Columbia University Irving Medical Center (CUIMC). The underlying philosophy of this program is that genetic approaches, including forward and reverse genetics as well as genomics and epigenomics, represent effective strategies for dissecting the molecular mechanisms underlying development and disease in vivo. GADD students receive advanced training in genetic analyses using model organisms, current genetic and genomic techniques, biostatistics, history of genetics, and the ethics of modern genetics.

PI_NAMEs: BERCHOWITZ, LUKE E;SHIRASU-HIZA, MICHELE M (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Development;Disease;genetic approach

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Hematology;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: In this proposal, I describe the successful invention of a novel positive-selection screening platform for degraders of transcription factors (TFs). I use it to identify Spautin-1 as a degrader of IKZF1 and propose experiments to (i) elucidate its mechanism of action and (ii) identify derivatives for Spautin-1 with increased potency against IKZF1. These studies will help develop a novel class of therapies against refractory myeloma.

PI_NAMEs: KODURI, VIDYASAGAR  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Address;Advisory Committees;Award;Binding;Binding Proteins;Biochemical;Biological Availability;Cancer Biology;career;Cell Line;Cells;Characteristics;Clinical;Complement;Credentialing;Dana-Farber Cancer Institute;Data;design;Development;Drug resistance;Drug Targeting;Educational process of instructing;Environment;experimental study;Generations;Genetic;Goals;Hematologic Neoplasms;immune modulating agents;immunomodulatory therapies;In Vitro;in vivo;in vivo Model;interest;invention;Knowledge;Laboratories;lenalidomide;leukemia;Ligands;Malignant Neoplasms;Maps;Mediating;Medical Oncologist;medical schools;Mentors;Modeling;Multi-Drug Resistance;Multiple Myeloma;Mutate;mutation screening;Neoplasms;novel;novel therapeutics;Oncogenic;Pathway interactions;Patient Care;patient derived xenograft model;Patients;pharmacokinetics and pharmacodynamics;pomalidomide;Post-Translational Modification Site;Pre-Clinical Model;Prognosis;programs;Proteins;Refractory;Regulation;Reporter;Research;Research Personnel;Research Training;Resistance;Resistance development;Sampling;screening;small molecule;Substrate Specificity;Surface;symposium;tenure track;Testing;Therapeutic;Time;tool;Training;transcription factor;ubiquitin-protein ligase;whole genome;Work;Xenograft Model

PROJECT_TITLE: Mechanism of Action of Spautin-1, A Novel Degrader of IKZF1

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Lung;Pediatric;Rare Diseases

PHR: The Acute Respiratory Distress Syndrome (ARDS) can be fatal to both children and adults, but its molecular mechanisms are not understood. This proposal uses advanced imaging techniques to further the understanding of the cell-cell communication that underlies ARDS, with a long-term goal of leading to the development of specific therapies for this devastating syndrome.

PI_NAMEs: HOUGH, REBECCA FRANCES (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acids;Acute Lung Injury;Acute Respiratory Distress Syndrome;Adult;Alveolar;alveolar epithelium;Alveolar wall;Alveolus;Animal Model;aspirate;Blood capillaries;blood perfusion;Blood Vessels;career;Cell Communication;Cells;Characteristics;Child;Childhood;Communication;design;Deterioration;Development;Disease;Edema;Endothelium;Epithelium;Event;Exposure to;Failure;fluorescence imaging;follow-up;Foundations;Glycolysis;Goals;Hour;Human;Hydrogen Peroxide;Hypoxemia;Imaging Techniques;Impairment;In Situ;Individual;Infant;Inflammatory;Infusion procedures;Injury;interstitial;Knowledge;Learning;Lipopolysaccharides;Liquid substance;Lung;lung development;lung injury;Mechanical ventilation;meetings;Membrane;Mentorship;Metabolic;Metabolism;Microscopy;Mitochondria;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;novel;Pediatric Acute Lung Injury;Pneumonia;Production;Property;Protons;Pulmonary Edema;Reactive Oxygen Species;Regulation;Research;Research Personnel;Research Project Grants;response;Role;Secondary to;Sepsis;Severities;Signal Transduction;Syndrome;targeted treatment;Techniques;Therapeutic;Tidal Volume;Time;UCP2 protein

PROJECT_TITLE: Mitochondrial mechanisms underlying alveolar-capillary barrier regulation

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Cancer;Hematology;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT: This application seeks to continue a training program with a proven record of training scholars and helping them acquire the necessary skills to design and execute impactful oncology clinical trials and conduct innovative cancer research.

PI_NAMEs: HUNGER, STEPHEN PATRICK;SCHUCHTER, LYNN M. (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;bench to bedside;Bioethics;Biometry;Cancer Center;career;Clinical;clinical epidemiology;Clinical Investigator;Clinical Oncology;Clinical Research;Clinical Trials Design;Development;Doctor of Philosophy;Education;Educational Curriculum;Enrollment;Environment;Epidemiology;expectation;experience;Fellowship;Funding;Goals;Grant;Gynecologic Oncology;Health Services Research;Hematology;high standard;Human;Human Resources;Institution;instructor;interest;K-Series Research Career Programs;Knowledge;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;medical schools;men;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Mission;Monitor;next generation;Oncology;patient oriented;Pediatric Hematology;Pediatric Hospitals;Pennsylvania;Philadelphia;Physicians;professor;programs;Publications;Radiation Oncology;Research;Research Personnel;Residencies;Resources;Scientist;Source;success;Time;tool;Training;Training Programs;Training Support;Translational Research;translational scientist;United States National Institutes of Health;Universities;Women's Group

PROJECT_TITLE: Physician Scientist Training in Clinical Oncology

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Kidney Disease

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF THE INCARNATE WORD

PHR: Project Narrative: Public Health Relevance Statement Diabetes and diabetic nephropathy (DN) are major causes of morbidity in the general population. There is an urgent medical need for identification of novel targets in the development of strategies for rational treatment of DN. Our objective is to characterize the role of Duox2 in DN and identify it as a convenient target for therapeutic intervention as identifying specific sources of oxidants will allow targeted therapy to prevent DN and could translate to treating patients with specific antioxidant therapy.

PI_NAMEs: FORD, BRIDGET M (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Activator Appliances;antioxidant therapy;Apoptosis;Biochemical;Biomedical Research;Calcium;Calcium-Binding Domain;cell injury;Cells;Data;design;Development;Diabetes Mellitus;diabetic;Diabetic Nephropathy;Education;EF Hand Motifs;Environment;Enzymes;Epithelial Cells;euglycemia;Event;experience;experimental study;extracellular;Family;Foot Process;Freezing;General Population;Generations;Glucose;Goals;High Fat Diet;hormone biosynthesis;Hydrogen Peroxide;Hyperglycemia;Immunohistochemistry;Impairment;In Vitro;in vivo;Infrastructure;Injury;Integral Membrane Protein;Intervention;Kidney;kidney cortex;Kidney Diseases;Knockout Mice;Lesion;Mediating;Mediator;Medical;member;Membrane;Molecular;Morbidity - disease rate;Morphology;Mus;N-terminal;NADPH Oxidase;Nature;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nox enzyme;Oxidants;Oxidases;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathologic;Pathology;Patients;Peroxidases;pharmacologic;phase II trial;Play;podocyte;prevent;protein expression;Proteins;public health relevance;Reactive Oxygen Species;Regulation;Renal function;Renin-Angiotensin System;Research;Role;slit diaphragm;Source;stem;Stress;subcellular targeting;Superoxides;System;targeted treatment;Testing;Therapeutic Agents;Therapeutic Intervention;Thyroid Gland;Thyroid Hormones;Tissues;Translating;Transmembrane Domain;type I and type II diabetes;underrepresented minority student;Universities;Up-Regulation;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Dual Oxidase 2 as a New Target for Treatment of Diabetic Nephropathy


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: The burden of cervical cancer and Kaposi’s sarcoma in sub-Saharan Africa is daunting; both cancers are common with poor survival because the region lacks effective prevention, early detection and treatment. Efforts to improve this are hindered by a shortage of qualified researchers and efficient research networks. We will create a multi-country collaboration amongst scientists in the U.S. and East Africa to conduct relevant research on prevention and early detection of these cancers while also training both East African and U.S. junior scientists.

PI_NAMEs: KAMBUGU, ANDREW DDUNGU;MARTIN, JEFFREY N (contact)

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: Address;advanced disease;Africa;Africa South of the Sahara;African;AIDS related cancer;anti-cancer research;Award;Back;Biometry;California;career development;Caring;cervical cancer prevention;Clinical;Clinical Research;clinically relevant;Collaborations;Communicable Diseases;Country;data management;Development;Diagnosis;Diagnostic tests;Disease;Early Diagnosis;Early treatment;epidemiology study;experience;Face;Foundations;Funding;General Hospitals;General Population;Health;HIV;HIV Infections;Home;improved;Incidence;Individual;Institution;interest;Junior Physician;K-Series Research Career Programs;Kaposi Sarcoma;Kenya;Knowledge;Lead;Leadership;Life Cycle Stages;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Massachusetts;Mediating;Medical Research;Mentors;Modeling;novel;operation;Patients;Performance;Persons;Pilot Projects;Prevention;Prevention strategy;Primary Prevention;Principal Investigator;Prognosis;Program Development;programs;prospective;Public Health;Qualifying;Research;Research Institute;Research Personnel;Research Project Grants;Research Training;Resource-limited setting;Resources;response;San Francisco;Science;Scientist;screening;Screening for cancer;Secondary Prevention;Shoulder;Structure;Tanzania;tool;Training;Translational Research;Uganda;United States;United States National Institutes of Health;United States National Library of Medicine;Universities;Viral;virus related cancer;Work

PROJECT_TITLE: United States-East Africa HIV-Associated Malignancy Research Center (USEAHAMRC) for Career Development and the Prevention, Early Detection and Efficient Linkage to Care for Virus-related Cancers


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunization;Immunotherapy;Skin Cancer;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Tumors help ensure their resistance to immune recognition by limiting dendritic cell and T cell function. This proposal will investigate a new mechanism harnessed by dendritic cells to enhance T cell responses, tumor rejection, and response to immunotherapy. The studies outlined in this proposal may lead to improved strategies to prevent and treat cancer.

PI_NAMEs: KLECHEVSKY, EYNAV YAFIT (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Address;Affect;anti-CTLA4;anti-PD-1;anti-tumor immune response;Antigen Presentation;Antigen-Presenting Cells;Binding;Blood;cancer cell;cancer therapy;cancer vaccination;Cancer Vaccines;Cell Physiology;Cells;Cellular biology;Cellular Immunity;checkpoint therapy;Classification;Color;Complement;CRISPR/Cas technology;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;Data;Dendritic cell activation;Dendritic Cells;Development;Disease;effector T cell;Ensure;experimental study;extracellular;fibrosarcoma;Generations;Genes;Human;human tissue;Humoral Immunities;Immune;immune checkpoint blockade;immune modulating agents;Immune response;Immunity;Immunologic Memory;Immunologic Surveillance;Immunotherapy;improved;in vivo;insight;Interferon Type II;Intervention;Laboratories;Laser Scanning Confocal Microscopy;lymph nodes;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;MHC Class I Genes;Minority;Modification;mouse model;Mouse Strains;Mus;Myelogenous;neoantigens;novel;Pathway interactions;Patients;Phenotype;Play;pre-clinical;prevent;Production;Productivity;Publishing;receptor;recruit;Regulation;Regulatory T-Lymphocyte;Resistance;response;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Skin;stem cell differentiation;stem cells;System;T cell response;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Tissues;Transforming Growth Factor beta;treatment response;tumor;Tumor Immunity;vaccine response

PROJECT_TITLE: The Role of CD5 in Tumor Immunity

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


PHR: This project will establish a network of scientists from the U.S., Uganda, Kenya, and Tanzania to study cancer in the context of HIV infection in sub-Saharan Africa. Composed of scientists from both the U.S. and Africa, the Administrative Core will ensure effective scientific leadership, communication and organization, and financial oversight to make efficient and responsible use of resources.

PI_NAMEs: MARTIN, JEFFREY N (contact)

PROJECT_TERMS: Administrative Coordination;Affect;Africa;Africa South of the Sahara;African;AIDS related cancer;Biomedical Research;career development;Caring;cohort;Collaborations;Collection;Communication;Communities;community engagement;Country;design;Doctor of Medicine;Early Diagnosis;Economics;Elements;Ensure;Environment;Feedback;Funding;Funding Opportunities;Generations;Goals;Hand;Health;HIV Infections;Hour;Institution;Internet;K-Series Research Career Programs;Kenya;Lead;Leadership;low and middle-income countries;Malignant Neoplasms;Master of Public Health;member;Mentors;Modeling;Monitor;multidisciplinary;organizational structure;Performance;Persons;Phase;Pilot Projects;Policies;Policy Maker;Politics;Positioning Attribute;Prevention;Principal Investigator;Process;programs;prospective;Reporting;Research;research and development;Research Personnel;Research Project Grants;Resources;response;Schedule;Scientist;skills;symposium;Tanzania;Technology;Time;Uganda;United States;United States National Institutes of Health;virus related cancer;Voice

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The primary goals of this K12 Mentored Clinical Scientist Development Award Application are to support intensive research mentorship, advanced training, and career development of diverse and talented, doctoral-level, clinically trained individuals committed to a career in patient- oriented addiction research. The critical need to expand a diverse and motivated scientific workforce with the skills required to effectively and independently advance and improve the care we can provide for the growing population of individuals with addictive disorders underpins the public health significance of the renewal of this successful training program.

PI_NAMEs: EVINS, A EDEN (contact);RIGOTTI, NANCY A

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: addiction;Applications Grants;career;career development;catalyst;Clinical;Clinical Research;Collaborations;Dedications;design;Drug abuse;Drug Addiction;Ensure;Environment;experience;Fostering;General Hospitals;Goals;Government;Group Meetings;Hospitals;improved;Individual;Industry;Institution;interest;Joints;Laboratory Research;Leadership;Massachusetts;Medical;medical schools;Medicine;member;Mentored Clinical Scientist Development Award (K08);Mentored Clinical Scientist Development Program;Mentors;Mentorship;multidisciplinary;National Institute of Drug Abuse;next generation;Paper;patient oriented;Postdoctoral Fellow;Productivity;professor;Program Development;programs;Psychiatry;Public Health;Recording of previous events;recruit;Research;research and development;Research Personnel;Resources;responsible research conduct;Role;role model;Scientist;skills;Substance Addiction;substance use;Talents;Training;training opportunity;Training Programs;Vision;Work;Writing

PROJECT_TITLE: Career Development Program in Substance Use and Addiction Medicine

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


PHR: In East Africa, as is the case in most of sub-Saharan Africa, junior scientists need substantial support following graduate training in order to become productive and independent scientists. In this project, we will create an academic environment for our emerging East African and U.S. junior scientists studying HIV- associated cancers that will help them improve their scientific productivity, scientific leadership, and administrative skills. We will also administer small research grants to identify the next group of junior scientists interested in studying HIV-related cancers.

PI_NAMEs: KAMBUGU, ANDREW DDUNGU (contact)

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;African;Age;AIDS related cancer;anti-cancer research;Area;Award;Back;California;career;career development;Caring;Clinical Research;cohort;college;Communicable Diseases;Country;Development;Doctor of Philosophy;Early Diagnosis;Environment;epidemiology study;experience;Funding;Future;Generations;Grant;Health Sciences;HIV;Home;improved;Individual;Institution;interest;International;Junior Physician;K-Series Research Career Programs;knowledge base;Leadership;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mentors;Mentorship;Methodology;Modeling;Molds;Pattern;Phase;Pilot Projects;Prevention;Principal Investigator;Process;Productivity;programs;prospective;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;response;San Francisco;Scientist;skills;Stream;Time;Training;Translational Research;Uganda;United States;United States National Institutes of Health;Universities;virus related cancer;Wages;Writing

PROJECT_TITLE: Developmental Core


PHR: This project will establish a network of scientists from the U.S., Uganda, Kenya, and Tanzania to study cancer in the context of HIV infection in sub-Saharan Africa. This research requires large amounts of data, which will need to be properly collected, organized, and analyzed. We will facilitate this process by creating a group with centralized expertise in data management and statistical analysis to assist our research projects and junior scientists from both the U.S. and East Africa as they continue to progress in their scientific careers.

PI_NAMEs: KIRAGGA, AGNES NAJJUKO (contact)

PROJECT_TERMS: Africa;Africa South of the Sahara;African;AIDS related cancer;Ally;Award;Biological;Biomedical Research;Biometry;Budgets;career;career development;Caring;Clinical Research;Communication;cost;Data;Data Analytics;Data Collection;data management;design;Development;Discipline;Doctor of Philosophy;Early Diagnosis;Educational process of instructing;Ensure;Epidemiology;epidemiology study;experience;Faculty;field study;Foundations;Frequencies;Funding;Future;Goals;HIV Infections;Human Resources;Image;Individual;Instruction;Kenya;Malignant Neoplasms;Master of Public Health;Medical Records;Methodology;Methods;novel strategies;Participant;Periodicals;Photography;Pilot Projects;Predisposition;Prevention;Principal Investigator;Process;prospective;Questionnaires;repaired;Research;Research Personnel;Research Project Grants;Resource Sharing;Resource-limited setting;Resources;Rest;Scientist;Seasons;skills;Solid;Specialist;Specimen;Statistical Data Interpretation;success;systems research;Tanzania;Techniques;Technology;Training;Training Programs;Translational Research;Uganda;United States;virus related cancer

PROJECT_TITLE: Data Management and Biostatistical Analysis Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Small cell lung cancer (SCLC) is a recalcitrant subtype of lung cancer for which there are limited treatment options. This study will employ novel mouse and patient-derived models of the disease as well as state-of-the- art technologies to determine the mechanisms by which arginine deprivation impacts the MYC-driven subtype of SCLC. This work is relevant to public health and the NIH mission because it will increase our understanding of the unique metabolic and therapeutic vulnerabilities in SCLC subtypes and ultimately improve the quality of life and survival of lung cancer patients.

PI_NAMEs: OLIVER, TRUDY GALE (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Amino Acids;Anabolism;Arginine;Arginine deiminase;argininosuccinate synthase;ASCL1 gene;ATAC-seq;Autophagocytosis;BETA2 protein;Biological Markers;cancer cell;Cancer Patient;cancer subtypes;cancer therapy;cancer type;Carbon;Cell Death;Cell Death Induction;Cell Line;Cells;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Chloroquine;Circulation;Clinical Trials;Combined Modality Therapy;Congresses;Data;deprivation;design;Disease;disease model;Drug Combinations;Environment;Enzymes;erastin;Extensive Stage;Family;Family member;Ferritin;Genetic;Genetically Engineered Mouse;Human;Human Cell Line;human disease;Immune system;Immunocompetent;Immunotherapy;improved;in vivo;innovation;Ireland;Knock-out;lung cancer cell;Lung Neuroendocrine Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mesenchymal;Metabolic;Metabolic Pathway;Metabolism;Mission;Modeling;molecular phenotype;molecular subtypes;mortality;mTOR inhibition;Mus;MYCL1 gene;NCOA4 gene;neoplastic cell;new therapeutic target;novel;Pathway interactions;patient derived xenograft model;patient stratification;Patients;Pharmaceutical Preparations;pharmacologic;Polyamines;Population;Public Health;Quality of life;Relapse;Research;Resistance;Resistance development;resistance mechanism;response;Role;Signal Transduction;single-cell RNA sequencing;small cell lung carcinoma;Solid Neoplasm;standard of care;Starvation;Survival Rate;targeted treatment;Technology;Testing;Therapeutic;Time;TP53 gene;transcription factor;transcriptome sequencing;treatment strategy;tumor;United States National Institutes of Health;Work;Xenograft Model

PROJECT_TITLE: Mechanisms of Arginine Deprivation in Small Cell Lung Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Tumor-associated blood vessels sustain the growth and promote the spread of cancer cells via diverse mechanisms. In this proposal, we have uncovered a new role for DNA methyltransferase 1 (DNMT1), the major enzyme responsible for re-establishing patterns of methylation during cell division, for the survival, specification, and immunosuppressive features of tumor-associated endothelial cells. We aim to explore the role of vascular DNMT1 in sprouting neovessels that sustain cancer cell growth, how DNMT1 is regulated by growth factors in the tumor endothelium, and how DNMT shapes immune/vascular micro environments in metastasis.

PI_NAMEs: DUDLEY, ANDREW CARL (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Adhesions;Angiogenesis Inhibitors;Angiogenic Factor;Area;Attention;Biological Assay;bioluminescence imaging;blood vessel development;Blood Vessels;Brain;Brain Neoplasms;Breast Cancer Model;cancer cell;Cancer Cell Growth;cancer immunotherapy;cancer survival;CD8-Positive T-Lymphocytes;Cell Adhesion Molecules;Cell Communication;Cell division;Cell Line;Cell Physiology;Cell Proliferation;Cell Survival;Cells;chemokine;Coculture Techniques;combinatorial;Complex;Cues;Cyclic AMP-Dependent Protein Kinases;Cyclin-Dependent Kinase Inhibitor;Cytotoxic T-Lymphocytes;derepression;Development;DNA delivery;DNA Methylation;DNA Modification Methylases;E-Selectin;Endothelial Cells;Endothelium;Environment;Enzymes;Epigenetic Process;Excision;FGF2 gene;Fibroblast Growth Factor Receptors;Flow Cytometry;Gatekeeping;Gene Silencing;Genes;Genetic;Genetically Engineered Mouse;Goals;Growth;Growth Factor;Heterogeneity;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immune Evasion;Immune system;Immunologic Surveillance;immunosuppressed;Immunosuppression;Immunotherapy;Impairment;improved;In Vitro;Infiltration;inhibitor;interest;Interferon Type II;Investments;Label;Link;loss of function;Lymphocyte Depletion;lymphocyte trafficking;Malignant Breast Neoplasm;Mediating;Metastatic malignant neoplasm to brain;Methylation;methylation pattern;Microfluidic Microchips;Modeling;monolayer;Morphogenesis;mouse model;Mus;nanoparticle;Neoplasm Metastasis;Neoplasms in Vascular Tissue;neoplastic cell;neovascularization;Normal tissue morphology;Pathway interactions;Penetration;Perfusion;Permeability;Play;Positioning Attribute;Primary Neoplasm;Proliferating;Protein Kinase C;recruit;Research Personnel;Role;Shapes;single-cell RNA sequencing;Small Interfering RNA;Solid Neoplasm;Specific qualifier value;stem cell self renewal;Structure;T-Lymphocyte;TNF gene;treatment strategy;Tropism;tumor;Tumor Biology;Tumor Burden;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;tumor-immune system interactions;Tyrosine Kinase Inhibitor;Work

PROJECT_TITLE: Targeting the vasculature to enhance anti-tumor immunity

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Cost Effectiveness Research;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

PHR: Despite the availability of effective prevention methods, Sub-Saharan Africa still accounts for nearly 90% of the global cervical cancer burden. This research will evaluate a new integrated community-based prevention and early detection program for cervical cancer implemented by the Ministries of Health in Kenya and Uganda. The findings will provide a new paradigm in cervical cancer prevention in Africa – a public health approach to reach the greatest number of girls and women at the lowest cost.

PROJECT_TERMS: access disparities;Address;Africa;Africa South of the Sahara;AIDS related cancer;Cancer Burden;Cancer Control;career development;Caring;Cervical;cervical cancer prevention;Cervical Cancer Screening;Communities;Community based prevention;cost;Cost Analysis;cost comparison;cost effectiveness;Data;Disease;Dose;Early Diagnosis;Evaluation;Female Adolescents;Funding;girls;Goals;Hand;Health;Health Services Accessibility;High Prevalence;HIV;HIV Infections;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immunize;improved;Incidence;Infection Control;Kenya;Literature;Malignant - descriptor;Malignant neoplasm of cervix uteri;Methods;microcosting;Modeling;mortality;Motion;premalignant;Prevention;Prevention program;preventive intervention;Primary Prevention;programs;Public Health;Recommendation;Research;Research Project Grants;Residual state;screening;Screening for cancer;Secondary Prevention;Series;Specimen;success;Testing;Time;tool;Uganda;United States;uptake;Vaccinated;Vaccination;Vagina;virus related cancer;Woman;women's treatment;Work;World Health Organization

PROJECT_TITLE: Project 1: A Public Health Approach to Cervical Cancer Prevention in East Africa


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The ability to treat disease and injury of the brain depends upon developing a fundamental understanding of the complex neural circuits that comprise the central nervous system. The use of neurotrophic viruses as transneuronal tracers provides a unique and powerful tool that reveals the functional organization of these complex circuits. The CNNV is a national resource that provides training in the use of this approach and distributes reagents to a world-wide cadre of investigators.

PI_NAMEs: STRICK, PETER  (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Affective;Architecture;Biohazardous Substance;Brain Injuries;Central Nervous System;Cognitive;Collaborations;Communities;Complex;Core Facility;Development;Disease;Dissection;experimental study;Foundations;Funding;Goals;Herpesviridae;improved;Individual;insight;interest;International;investigator training;Methods;Motor;Nervous System;neural circuit;Neuroanatomy;neuronal transport;Neurons;Neurosciences;neurotropic virus;nonhuman primate;novel strategies;Pilot Projects;Play;Privatization;Rabies virus;Reagent;Recording of previous events;repository;Research;Research Personnel;Resources;Role;Sensory;Source;Targeted Research;Techniques;Technology;tool;Tracer;Training;United States National Institutes of Health;Universities;Viral;Virus

PROJECT_TITLE: Center for Neuroanatomy with Neurotropic Viruses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-D(55)R]


NIH_SPENDING_CATS: Cancer

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE The Cancer Epigenetics Training Program at Van Andel Research Institute (VARI) will prepare postdoctoral fellows to become independent research leaders in the field of cancer epigenetics. The program will accomplish this by offering cutting-edge, interdisciplinary research training in structural and functional aspects of epigenetics, complemented by state-of-the-art institutional resources, unique professional development activities, and integration with established translational research programs and partnerships led by VARI investigators. Trainees will emerge from the program with comprehensive training in cancer epigenetics and a professional foundation from which to launch their independent research careers.

PI_NAMEs: JONES, PETER A (contact)

PROJECT_TERMS: Epigenetic Process;Malignant Neoplasms;Training Programs

PROJECT_TITLE: Cancer Epigenetics Training (CET) Program