NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Methamphetamine;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRITIVE Evidence suggests that the United States has entered a ‘fourth wave’ of mortality in the current opioid epidemic, largely due to increased overdose deaths associated with use of fentanyl (and other synthetic opioids) and co-use of methamphetamine and other psychomotor stimulants. Polysubstance use, which is very common in clinical populations, is understudied in preclinical research, which may contribute to the minimal number of effective treatments for opioid use disorder. Therefore, the proposed studies evaluate the behavioral and neurobiological effects and interactions of co-use of fentanyl and methamphetamine to identify adaptations to the mesolimbic dopamine system that are unique to polysubstance uses.

PI_NAMEs: DAWES, MONICA H (contact)

PROJECT_TERMS: Acute;Address;Affect;Animals;awake;Behavior;Behavioral;Brain;Chronic;Clinical;clinically significant;Complex;Cues;Data;Disease;Dopamine;dopamine system;Dose;Drug Exposure;drug of abuse;Drug usage;Dynorphins;effective therapy;Event;Exposure to;Extinction;Feeling;Female;Fentanyl;fentanyl self-administration;fentanyl use;Fiber;Functional disorder;in vivo;Individual;innovation;insight;Intake;invention;kappa opioid receptors;Kinetics;Laboratories;Ligands;male;Measures;mesolimbic system;Methamphetamine;methamphetamine use;Microdialysis;mortality;Neurobiology;norbinaltorphimine;novel;Nucleus Accumbens;Opioid;Opioid Antagonist;opioid epidemic;opioid overdose;opioid use disorder;overdose death;Periodicity;Pharmaceutical Preparations;pharmacologic;Photometry;polysubstance use;Population;pre-clinical research;Rattus;receptor function;Reinforcement Schedule;Relapse;response;Rewards;Rodent Model;Role;Scanning;Schedule;Self Administration;sensor;Sex Differences;side effect;Signal Transduction;Slice;Stimulant;substance use;synthetic opioid;System;Techniques;Time;transmission process;United States;Withdrawal

PROJECT_TITLE: Characterization of Polysubstance Use: Combined Fentanyl and Methamphetamine


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF EDUCATION

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: LOGAN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PHR: Project Narrative  Severe problem behavior (e.g., self-injurious behavior, aggression) of children with intellectual developmental disorder is prevalent, potentially dangerous, and negatively impacts social integration and quality of life. Function-based, differential reinforcement of alternative behavior interventions reduce such behavior effectively, but treatment relapse is common when a caregiver does not deliver reinforcement for the alternative behavior. This translational project represents an integrated and unique collaboration between basic and clinical researchers to identify innovative theory-driven methods to reduce such treatment relapse.

PI_NAMEs: SHAHAN, TIMOTHY A (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Affect;Aggressive behavior;Animal Testing;Basic Science;Behavior;Behavior Therapy;behavioral momentum;Caregivers;Child;Child Behavior;Clinic;Clinical;clinical application;clinical practice;Clinical Research;Collaborations;comorbidity;Complex;Dangerousness;Data;developmental disease;Discrimination;Discrimination Learning;Educational process of instructing;Empirical Research;experience;experimental study;Exposure to;Extinction;Family;Future;improved;Individual;Infant;innovation;Intellectual functioning disability;Laboratory Animals;Laboratory Study;Laws;Learning;Length;Methods;National Institute of Child Health and Human Development;Participant;Patients;Phase;Problem behavior;Procedures;Psychological reinforcement;Quality of life;Randomized, Controlled Trials;Rattus;reinforcer;Relapse;relapse prevention;Research Personnel;response;Scientist;Self-Injurious Behavior;Series;severe behavior problem;Siblings;social integration;Stimulus;Testing;theories;Thinness;Time;Training;treatment as usual;treatment duration;Variant

PROJECT_TITLE: Basic and Clinical Studies in Reinforcing Positive Behaviors in Intellectual and Developmental Disabilities

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Cancer;Cervical Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Despite the success of cancer screening as an impactful cancer control strategy, utilization is suboptimal and disparities in screening rates by race and ethnicity persist, contributing to the disparities in cancer-specific survival. Improving utilization of cancer screening is critical to achieve population-level mortality reduction, but care must be taken to tailor interventions to underserved populations to ensure that existing disparities are narrowed, rather than widened. This research will address a critical gap in our understanding of multilevel drivers of cancer screening rates by incorporating healthcare system-level factors and advancing understanding of patient- and provider-level factors while focusing on racial and ethnic disparities.

PI_NAMEs: DEL VECCHIO, NATALIE  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adherence;Affect;Attitude;Award;Belief;Breast Cancer Detection;cancer care;Cancer Control;Cancer Etiology;cancer health disparity;cancer prevention;cancer survival;cancer type;career;career development;Caring;Cervical Cancer Screening;Cessation of life;clinical decision support;Clinical Trials;Colorectal Cancer;colorectal cancer screening;Community Healthcare;Data;Death Rate;Development;Development Plans;Disparity;Dose;Ensure;ethnic disparity;ethnic diversity;Ethnic Origin;experience;Goals;health care delivery;Health Care Rationing;Health Disparities Research;health disparity;Health system;Healthcare Systems;implementation science;improved;improved outcome;Incentives;Incidence;Integrated Health Care Systems;Intervention;Interview;Knowledge acquisition;Lung;lung cancer screening;Lung CAT Scan;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant Neoplasms;Mentorship;mortality;mortality disparity;multilevel analysis;National Cancer Institute;Outcome;outcome disparities;Patients;Policies;Population;Population Heterogeneity;Population Research;primary care provider;Process;programs;Provider;provider factors;Qualitative Evaluations;Race;racial disparity;racial diversity;Recommendation;Regulation;Research;Research Methodology;Research Personnel;Sampling;screening;Screening for cancer;screening policy;screening program;Shapes;skills;Structure;success;support tools;Surveys;Testing;Theoretical model;Training;Underserved Population;uptake;Work

PROJECT_TITLE: Assessing how multilevel factors shape disparities in cancer screening


ADMINISTERING_IC: AI

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Treatment strategies for multiple sclerosis patients that redirect the immune response away from inflammation without leaving patients immunocompromised are urgently desired. In this project, I will design a controlled-release biomaterial drug delivery system composed entirely of immune cues and loaded with an immunosuppressant drug to target the innate and adaptive immune system involved in multiple sclerosis. This plan is expected to provide insight that informs the design of new therapies to treat MS and other autoimmune diseases such as type 1 diabetes and rheumatoid arthritis.

PI_NAMEs: ACKUN-FARMMER, MARIAN ADRIANA (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adaptive Immune System;adaptive immunity;Address;Amines;antagonist;Antigen-Antibody Complex;Antigen-Presenting Cells;Antigens;Autoantigens;Autoimmune Diseases;Autoimmunity;Biocompatible Materials;blood-brain barrier crossing;capsule;career;career development;Cells;Central Nervous System;Characteristics;Charge;combat;controlled release;crosslink;Cues;cytotoxic CD8 T cells;Data;Dendritic Cells;density;design;Disease;Disease Progression;draining lymph node;Drug Delivery Systems;Drug Modelings;Electrostatics;Environment;Exhibits;FRAP1 gene;Gene Expression;Goals;High Pressure Liquid Chromatography;Immune;immune modulating agents;Immune response;Immune signaling;Immune system;Immune Targeting;Immune Tolerance;Immunocompromised Host;Immunohistochemistry;Immunology;immunoregulation;Immunosuppression;Immunosuppressive Agents;Impairment;improved;In Vitro;Infection;Inflammation;Inflammatory;Innate Immune System;insight;Insulin-Dependent Diabetes Mellitus;interest;Investigational Therapies;Investments;Kinetics;Lead;Libraries;Link;Lipids;Lymphocyte;Macrophage;Measures;Modeling;Molecular;Morphology;mouse model;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Myelin;Myelin Sheath;Natural Immunity;Natural Killer Cells;Neurologic;Neurons;new technology;novel therapeutics;Oligonucleotides;Pathogen detection;Pathway interactions;Patient Compliance;Patients;Pattern;Pharmaceutical Preparations;Play;polarized cell;Polymers;post-doctoral training;pre-clinical;Predisposition;Property;Quality of life;Reaction;receptor function;Receptor Signaling;Regulatory T-Lymphocyte;Reporter;Research;response;Rheumatoid Arthritis;Role;secondary lymphoid organ;self assembly;Severities;Signal Pathway;Signal Transduction;Sirolimus;skills;Structure;Surface;T-Lymphocyte;Techniques;Testing;Time;Toll-like receptors;trafficking;Training;treatment strategy;United States National Institutes of Health;uptake;Work

PROJECT_TITLE: Developing controlled release immune complexes to treat multiple sclerosis


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Hematology;Nanotechnology;Rare Diseases;Sickle Cell Disease

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Our laboratory takes a multidisciplinary approach spanning biology, physics, engineering, and medicine to develop new tools to answer hematologic questions that are technologically infeasible with current systems. While our basic interests involve developing microtechnologies to investigate the biophysics of hematologic processes at the micro-to-nanoscales, these microdevices can then be adapted to function as novel pre-clinical disease models, clinical diagnostics, and drug discovery platforms. Overall, we adopt a “basement-to-bench-to- bedside” approach in which the invention, translation, and clinical assessment of diagnostic and therapeutic microtechnologies takes place under one scientific “roof” with the ultimate goal of improving the lives of patients with blood disorders.

PI_NAMEs: LAM, WILBUR A (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Address;Adopted;bench to bedside;Biochemical;Biocompatible Materials;Biological Assay;Biological Markers;Biology;Biomedical Engineering;Biophysics;Blood;Blood Platelets;Cell Communication;Cells;Circulation;Clinical;Clinical assessments;clinical diagnostics;Collagen;Complex;Diagnostic;Diagnostic Equipment;Disease;disease model;Drug Delivery Systems;drug discovery;endothelial dysfunction;Endothelium;Engineering;Environment;Extravasation;Functional disorder;Genes;Goals;Health;Hematological Disease;Hematology;Hemorrhage;Hemostatic function;Hydrogels;Idiopathic Thrombocytopenic Purpura;improved;In Vitro;in vitro Model;interdisciplinary approach;interest;invention;Laboratories;Leukocyte Rolling;Mechanics;Medicine;microdevice;Microfluidics;Modeling;Molecular Biology;nanoscale;nanosystems;new technology;novel;organ on a chip;Patients;Physicians;Physics;Physiological;Platelet aggregation;Play;pre-clinical;Process;programs;Research;Scientist;Sickle Cell Anemia;Signal Pathway;System;Technology;technology development;technology platform;Therapeutic;Thrombosis;tool;Training;Translating;Translations;Vascularization;Work

PROJECT_TITLE: Engineering biophysical microtechnologies for hematologic applications in health and disease


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: MARBLEHEAD

ORG_NAME: IMPLENOMICS LLCS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Kenya has a high incidence of breast and cervical cancers, and most women are diagnosed with late-stage disease. We will conduct a study to assess the effectiveness and cost-effectiveness of strategies to increase the uptake of cancer screening and completion of recommended diagnostic and treatment services. The findings can be used to design optimal approaches and plan investments in infrastructure to scale up implementation of breast and cervical cancer screening.

PI_NAMEs: SUBRAMANIAN, SUJHA  (contact)

PROGRAM_OFFICER_NAME: JALLOW, FATOU

PROJECT_TERMS: Address;Adopted;African;aged;Awareness;Behavioral;Breast Cancer Detection;Breast Cancer Early Detection;cancer care;Cancer Control;Cancer Detection;Catchment Area;Cervical Cancer Screening;Clinic;Cluster randomized trial;Communication;Communities;community clinic;community clinical linkage;Community Health;Community Practice;community setting;Continuity of Patient Care;cost effectiveness;Cost Effectiveness Analysis;cost efficient;Country;Data;design;Diagnostic;Diagnostic Services;Diagnostic tests;Disease;DNA;Education;effectiveness evaluation;Eligibility Determination;empowerment;Ensure;evidence base;Family member;follow-up;Fostering;Funding;Future;Goals;Grant;Guidelines;Health;Health care facility;Health system;Human Papillomavirus;implementation evaluation;implementation facilitators;implementation intervention;implementation outcomes;implementation strategy;improved;improved outcome;Incidence;Individual;Infrastructure;Investments;Kenya;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mammography;Methods;Modeling;mortality;Motivation;motivational enhancement therapy;multimodality;National Cancer Institute;optimal treatments;Outcome;Pap smear;Pathway interactions;Patients;Phase;Play;policy implication;Population;posters;Procedures;Process;process improvement;Program Efficiency;programs;Recommendation;Research;Resources;Role;scale up;screening;Screening for cancer;screening services;Self Efficacy;Series;Services;social stigma;standard of care;team-based care;Testing;theories;treatment services;uptake;volunteer;Woman;women's diagnosis;Women's study

PROJECT_TITLE: An integrated community-clinic model of optimized implementation strategies to increase early detection of breast and cervical cancers in Kenya

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative There is great interest in defining cancer drug targets that are uniquely expressed in tumor cell lineages, as the pharmacological inhibition of these targets can cause tumor-specific cell death while sparing normal tissues which do not express the target. In this proposal, we describe our recent discovery that an enzyme complex, PI3Kg, is selectively expressed and functional in cells that give rise to a class of cancers known as myeloid leukemias. In the proposed studies, we will evaluate the fundamental role that PI3Kg plays in acute myeloid leukemia (AML), the most lethal of these diseases, while also evaluating whether its inhibition can safely and effectively treat advanced patient-derived and animal models of the disease, thus establishing a foundation for the clinical development of PI3Kg inhibitors as a new class of safe and effective AML therapies.

PI_NAMEs: WOOD, KRIS C. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Agammaglobulinaemia tyrosine kinase;Animal Disease Models;Animal Model;Anthracycline;Anti-androgen Therapy;Antineoplastic Agents;antitumor effect;Area;B-Lymphocytes;BCL1 Oncogene;Bone Marrow;Breast;cancer therapy;Cell Culture Techniques;Cell Death;Cell Line;Cell Lineage;Cell Survival;cell type;Cells;Chemoresistance;chemotherapy;Chronic;Chronic Lymphocytic Leukemia;Chronic Myeloid Leukemia;clinical development;Credentialing;CRISPR screen;cytotoxic;Dependence;Development;Diagnosis;Disease;disease model;disorder control;Drug Targeting;Dysmyelopoietic Syndromes;Estrogen Antagonists;Event;Exhibits;Flow Cytometry;Foundations;Genetic;Genetically Engineered Mouse;Genomics;Hematologic Neoplasms;Hematology;Hematopoietic;Hematopoietic System;high risk;Holoenzymes;Human;Human Cell Line;humanized mouse;improved;improved outcome;inhibitor;inhibitor therapy;interest;leukemia;leukemia treatment;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Molecular;Monoclonal Antibody Therapy;mortality;MS4A1 gene;Multienzyme Complexes;Mus;Myelodysplastic/Myeloproliferative Disease;Myelogenous;Myeloid Cells;Myeloid Leukemia;Myeloproliferative disease;neoplastic;neoplastic cell;Neural Crest;Neuroblastoma;Normal Cell;Normal tissue morphology;novel;older patient;Outcome;Pathogenesis;patient derived xenograft model;Patient-Focused Outcomes;Patients;pharmacologic;phosphatidylinositol 3-kinase gamma;PIK3CG gene;Play;Primary Myelofibrosis;Proliferating;Prostate;Protein Isoforms;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Resolution;Role;Safety;screening;selective expression;side effect;Signal Transduction;Sorting;standard of care;survival outcome;Survival Rate;System;systemic toxicity;targeted treatment;Technology;Therapeutic;Translating;translational potential;Treatment Efficacy;tumor;Validation;Xenograft procedure

PROJECT_TITLE: Lineage-specific signaling and targeting of PI3K gamma in myeloid malignancies

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The use of ponatinib and other tyrosine kinase inhibitors for CML and other cancers are associated with an increased risk for cardiovascular events approaching 30% of patients. We have observed that ponatinib increases thrombosis risk in rodents by increasing vascular inflammation and inducing hyperactive platelets. In our experimental models, ponatinib use is associated with immune cell vascular inflammation. On RNAseq of aorta, we note increased expressed of genes associated with thrombosis. Further, we have observed increased signaling in platelets. The PPAR agonist pioglitazone corrects ponatinib-induced thrombosis risk and thrombosis gene expression and normalizes platelet hyperactivity. Presently we aim to expand the investigations on the mechanisms by which ponatinib increased thrombosis risk and broaden these investigations to all the TKIs used to treat CML.

PI_NAMEs: SCHMAIER, ALVIN H (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Adverse event;Agonist;Aorta;Apoptosis;artery occlusion;BCR gene;Blood coagulation;Blood Coagulation Factor;Blood Platelets;Blood Vessels;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cells;Chronic Myeloid Leukemia;Coagulation Process;Collagen;Combined Modality Therapy;Defect;Dose;Endothelial Cells;Enzymes;Event;Experimental Models;F8 gene;factor IXa-factor VIIIa;Factor V;Factor VIII;Gene Expression;Generations;Genes;Genomics;Goals;Hyperactivity;Imatinib;Immune;In Vitro;in vivo;Incidence;Infiltration;Inflammation;Inflammatory;Investigation;Ischemic Stroke;Laboratories;limb ischemia;LTK gene;Lymphocyte;Lymphocytic Infiltrate;Malignant Neoplasms;man;Morbidity - disease rate;mouse model;mRNA Expression;Mus;mutant;Myocardial Infarction;Nature;non-genomic;novel;old mice;Oncology;Organ;Patients;Pharmacologic Substance;phase II trial;Phenotype;phosphoproteomics;Pioglitazone;platelet function;Pre-Clinical Model;Protein Tyrosine Kinase;Reaction;Reactive Oxygen Species;Resistance;response;Risk;Rodent;Signal Pathway;Signal Transduction;Stroke;Therapeutic;Therapeutic Agents;Thromboplastin;Thrombosis;thrombotic;transcriptome sequencing;Translating;Tyrosine Kinase Inhibitor;Vascular Diseases;vascular inflammation;Venous;Venous Thrombosis

PROJECT_TITLE: Tyrosine Kinases and Thrombosis

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE There is a pressing need to make the bioscience research academic workforce in the US more inclusive. The UC Berkeley PREP program will support and prepare outstanding biomedical scientists who will excel as researchers and role models in an academic setting. Not only will this program allow scholars to acquire the tools needed for successful careers in research and sustained innovation to the benefit of all, but it will also inspire students from underrepresented groups to pursue graduate training and become valuable contributors to the future of biomedicine.

PI_NAMEs: GARRIGA, GIAN ;SCHALETZKY, JULIA  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Academia;Address;Advocate;Area;Award;Awards and Prizes;Belief;Biological Sciences;Biomedical Research;biomedical scientist;California;career;career development;college;Communication;Communities;community building;Data;Decision Making;Dedications;design;Development;Development Plans;disabled students;Disease;Doctor of Philosophy;doctoral student;education research;Educational workshop;empowerment;Equity;ethnic diversity;Event;Exercise;experience;experimental study;Faculty;faculty mentor;Feedback;Funding;Future;Goals;graduate school;graduate school preparation;graduate student;Grant;GRE Preparation;higher education;improved;Individual;innovation;Institution;Interview;Journals;Laboratories;Laboratory Research;Leadership;Learning;meetings;member;Mentors;Mentorship;Modeling;neglect;notch protein;Paper;Personal Growth;Population;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;Press Releases;Process;Productivity;Program Development;programs;Publications;racial diversity;recruit;Relationship-Building;Research;Research Personnel;Research Training;Resources;role model;Scholars Program;Science;Scientist;skills;Specialist;student mentoring;Students;success;support network;System;Talents;Time;tool;tool development;Training;training opportunity;Translating;Travel;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;Writing

PROJECT_TITLE: PREP @ UC Berkeley

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Rare Diseases

ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative This training program provides research training and curricular-based training to a pool of talented, highly motivated students recruited into our Trainers’ laboratories, with training focused on cystic fibrosis (CF) to provide a disease-centric but widely applicable learning experience. Students are nurtured in a highly interactive environment; all trainees enroll in a core course, several courses in ethics, several advanced courses, and career development workshops pertinent to their area of research training. In addition to participating in weekly seminar series and journal clubs and presenting their work at joint lab meetings, retreats, an annual graduate program Research in Progress seminar, and annual Dartmouth CF Retreat open to all members of DartCF, Trainees supported by this T32 award are also provided with a series of additional enrichment activities, including attendance at the CF Clinical Conference, seminar speaker invitations, funds for travel to meetings and to attend off-site courses and career workshops, supplemental guidance with Individual Development Plans, the ability to present at the Dartmouth CF Retreat, and leadership and mentored teaching opportunities.

PI_NAMEs: O'TOOLE, GEORGE A. (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Cystic Fibrosis;Training Programs

PROJECT_TITLE: Dartmouth Cystic Fibrosis Training Program

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative – Overall Diabetes, obesity, and associated complications account for a major share of disease burden and health care costs nationwide. The Michigan Metabolic Phenotyping in Live Models of Obesity and Diabetes Center (MPMOD) will provide standardized, high quality and state-of-the-art in vivo phenotyping services for investigators ̶with focus on underrepresented PIs and small laboratories that have not received significant federal research funding ̶to boost the development of novel therapeutic strategies. The advanced phenotyping services include hyperinsulinemic-euglycemic clamps with tracers, indirect calorimetry with dietary and environmental temperature challenges, ultradian hormone analysis (automated blood sampling from freely- moving undisturbed mice) and behavioral measurements (hedonic and homeostatic feeding, obesity-induced depression, anxiety, etc).

PI_NAMEs: ELIAS, CAROL FUZETI (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Accounting;Advertising;animal care;Animal Experiments;Animal Model;Animals;Anxiety;Area;arm;base;Basic Science;Behavior assessment;behavior measurement;Behavioral;behavioral phenotyping;behavioral response;Biological;Biomedical Research;blood glucose regulation;Blood specimen;brain surgery;burden of illness;Cannulations;Chronic;Circadian Dysregulation;comorbidity;Consultations;Core Facility;cost;Culex (Genus);Data;Databases;Development;Diabetes Mellitus;dietary;Educational workshop;experience;Experimental Designs;feeding;Fiber;Fostering;Funding;Genetic;Germ-Free;Glucose;Glucose Clamp;glucose tolerance;Goals;Grant;Health;Health Care Costs;Health system;hedonic;Homeostasis;Hormone secretion;Hormones;Housing;Human;Hyperinsulinism;Hypothalamic structure;improved;in vivo;Indirect Calorimetry;Individual;Indwelling Catheter;Institution;Insulin Resistance;Investments;Laboratories;Leadership;Learning;Lipids;Liquid substance;Medicine;member;Mental Depression;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Michigan;Modeling;Morbidity - disease rate;mortality;Motor Activity;mouse genetics;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;novel;novel therapeutic intervention;Obesity;obesity treatment;Operant Conditioning;Operative Surgical Procedures;optogenetics;outreach;Parabiosis;Pathogenesis;Pattern;Phenotype;Photometry;Physical activity;Physiological;Physiology;Portal vein structure;Protocols documentation;Reproducibility;Research;Research Personnel;Resources;response;Role;Sampling;Services;Standardization;Technology;Temperature;Testing;tool;Tracer;Training;Training Programs;Translational Research;Transportation;Universities


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

PROJECT_TERMS: Administrator;Advertisements;Advisory Committees;animal care;Animals;behavioral phenotyping;Biotechnology;Budgets;Charge;Communication;Complex;Contracts;cost;Counseling;Data;Data Analyses;data submission;Databases;Development;Diabetes Mellitus;Ensure;Equipment;experience;Fee-for-Service Plans;Feedback;Funding;Germ-Free;Guidelines;Income;Institution;Laboratories;Leadership;meetings;Metabolic;metabolic phenotype;Michigan;Modeling;Monitor;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;nutrition;Obesity;Phenotype;Physiological;Preparation;Principal Investigator;Procedures;programs;Progress Reports;Protocols documentation;Quality Control;Records;Recovery;Reporting;Research;Research Personnel;Resources;Schedule;Secure;Services;Standardization;synergism;Technology;Training;Universities;web site;Work

PROJECT_TITLE: Core A: Administrative Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Poverty and opioid addiction are interrelated and chronic problems which have not been addressed adequately. This Stage III application seeks to develop and evaluate a Therapeutic Workplace that community treatment programs can implement and that arranges low-cost abstinence-contingent wage supplements to maintain drug abstinence and employment. If low-cost abstinence-contingent wage supplements in the community Therapeutic Workplace maintain drug abstinence and employment and decrease poverty, community drug-abuse treatment clinics could apply this intervention widely as a long-term maintenance treatment for unemployed adults with opioid use disorder.

PI_NAMEs: SILVERMAN, KENNETH  (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Abstinence;Address;Adult;base;Buprenorphine;buprenorphine treatment;Chronic;Clinic;Cocaine;common treatment;Communities;community clinic;contingency management;cost;drug abstinence;Drug abuse;Drug usage;effective therapy;effectiveness evaluation;Employment;Exclusion;food insecurity;Health Services;Hour;improved;Intervention;Maintenance;Measures;Mental Depression;Methadone;methadone treatment;Modification;Nature;Opiate Addiction;Opioid;opioid overdose;opioid use disorder;Outcome Measure;Participant;Patients;Persons;Pharmaceutical Preparations;Poverty;poverty reduction;primary outcome;Psychological reinforcement;psychosocial;Randomized;randomized, controlled study;real world application;relapse prevention;Risk;Sampling;Specialist;Therapeutic;Therapeutic community technique;treatment as usual;treatment program;Unemployment;Urine;Wages;Work;Workplace

PROJECT_TITLE: Long-Term Treatment of Opioid Use Disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Lung;Pulmonary Fibrosis;Rare Diseases

PHR: PROJECT NARRATIVE Alterations in DNA methylation, particularly within mesenchymal cells, plays a key role in the pathogenesis of idiopathic pulmonary fibrosis (IPF), but a complete analysis of the global methylome and how it varies among different mesenchymal cell populations has not been examined. This proposal will examine the heterogeneity of DNA methylomic patterns within IPF mesenchymal cells, investigate how methylation influences gene expression, and determine how the methylome is regulated by the actions of various methylation machinery. These findings will provide insight into the importance of DNA methylation in IPF and how methylation changes may be targeted for future therapy.

PI_NAMEs: HUANG, STEVEN K (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Affect;Area;ATAC-seq;Binding;bisulfite sequencing;Cell division;Cells;Chromatin;Cicatrix;Data;demethylation;Disease;Disease Progression;DNA;DNA Methylation;DNA Modification Methylases;Effector Cell;Environmental Risk Factor;Enzymes;Epigenetic Process;Extracellular Matrix;Fibroblasts;Future;Gene Expression;Gene Expression Profile;Genes;Genome;Grant;Heterogeneity;Histologic;histone methylation;Histones;idiopathic pulmonary fibrosis;in vitro Model;in vivo;Individual;insight;Knock-out;Knowledge;laser capture microdissection;lens;Lung;Lung Diseases;Lysine;Mediating;Mesenchymal;Methylation;methylome;methylomics;Molecular Conformation;Myofibroblast;Nature;overexpression;Pathogenesis;Pathologic;Patients;Pattern;Phenotype;Play;Population;Production;Pulmonary Fibrosis;recruit;Regional Anatomy;Regulation;Role;Shapes;single-cell RNA sequencing;Site;targeted treatment;Testing;Time;Up-Regulation;Variant;whole genome

PROJECT_TITLE: Heterogeneity and Regulation of the DNA Methylome in IPF Mesenchymal Cells

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Bioengineering

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Instrumentation to study mechanisms mediating effects of the critical dissolved gas signals CO, NO and H2S is being developed. The new tools will be used to understand and develop therapies for a wide range of conditions including diabetes, transplant rejection, sepsis, atherosclerosis and cancer, that are ameliorated by the cytoprotective properties of these gases.

PI_NAMEs: KRAMLICH, JOHN C.;SWEET, IAN R (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Acute;analytical tool;Anti-Inflammatory Agents;aqueous;Astronauts;Atherosclerosis;Binding;Biochemical;Bioenergetics;Biological;Biological Sciences;Blood flow;Blood gas;Carbon Dioxide;Cells;Chemicals;Clinical;Collaborations;Complex;Culture Media;Cytoprotection;Data;Data Reporting;Dependence;design;design and construction;Development;Devices;Diabetes Mellitus;Engineering;Equilibrium;Evaluation;experience;Exposure to;fundamental research;Future;Gases;Goals;Graft Rejection;Heart Rate;Hormone secretion;Hormones;Hypothalamic structure;Immune response;Industry;Institution;instrument;instrumentation;insulin secretion;Islets of Langerhans;Kinetics;Malignant Neoplasms;mathematical model;Measures;Mechanics;Mediating;Metabolic Pathway;Methodology;Methods;Modality;NADH;Neurotransmitters;novel;Oils;Oxygen Consumption;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Physiological;Play;Process;Production;Property;protein purification;Proteins;Protocols documentation;Provider;Publishing;Reaction Time;Regulation;Research;Research Personnel;response;Retina;Role;Sampling;Sepsis;Signal Transduction;Signaling Molecule;Solubility;Specific qualifier value;System;Technology;technology development;temporal measurement;Testing;therapeutic evaluation;therapy development;Time;Tissue Microarray;Tissue Model;Tissues;tool;Toxic Environmental Substances;Tube;user-friendly;Validation;Water;Work

PROJECT_TITLE: Development of Analytical Tools for Concentration and Real-Time Control of Dissolved Gases and Their Regulation of Tissue Function

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


PI_NAMEs: KENNEDY, LUCY HOFFMANN (contact)

PROJECT_TERMS: Accreditation;Adherence;American;animal care;Animal Experimentation;Animals;Behavior;Blood;Body Weight;Caring;Certification;college;Consultations;Derivation procedure;Diabetes Mellitus;Diet;Dose;Ensure;Environmental Monitoring;Experimental Designs;Fasting;Feces;Film;flexibility;Genetic Engineering;germ free condition;Germ-Free;Glucose;Gnotobiotic;Goals;Guidelines;Health;Health Status;Housing;IACUC;Inbred BALB C Mice;Institution;Laboratories;Laboratory Animal Medicine;Laboratory mice;Maintenance;metabolic phenotype;Michigan;Modeling;Monitor;Mus;Obesity;pathogen;Personal Satisfaction;Phenotype;Play;Process;Protocols documentation;Quarantine;Reproducibility;Research;Research Personnel;Role;sample collection;segregation;Services;Techniques;Technology;Training;United States Department of Agriculture;Universities;Urine;ventilation;Veterinarians;Workplace

PROJECT_TITLE: Core B: Animal Core and Germ-Free Mouse Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Episodes of altered mental status, from slight confusion to delirium to coma, are a leading complication of acute medical illness in hospitalized patients and are associated with increased risk of death, long-term cognitive impairment, and increased risk of vascular dementia and Alzheimer’s dementia. This study seeks to improve understanding of the mechanisms that govern the brain’s pathologic response (encephalopathy and delirium) to the metabolic derangements during acute medical illness and how those mechanisms influence cognitive impairment and subsequently increased risk for developing early vascular dementia, Alzheimer’s dementia, or other related dementias after acute medical illness.

PI_NAMEs: LIOTTA, ERIC MICHAEL (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acceleration;Acute;acute stroke;Aging;Alzheimer's Disease;Amino Acids;Animal Model;Area;arm;Aromatic Amino Acids;Astrocytes;Biological Markers;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier permeabilization;Brain;Brain Injuries;brain volume;career;career development;cell injury;Cell model;Cephalic;cerebral autoregulation;Cerebral Edema;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrum;Cessation of life;Chronic;Clinical;Cognition;Cognitive;cohort;Coma;Complex;Complication;Confusion;COVID-19;Critical Illness;Data;Delirium;Dementia;Development;Doctor of Philosophy;early onset;Edema;Elements;Encephalopathies;Ensure;Evaluation;follow-up;Foundations;functional decline;Functional disorder;Functional impairment;functional outcomes;gain of function;Glasgow Coma Scale;Glial Fibrillary Acidic Protein;Glutamates;Goals;Hepatic Encephalopathy;Hospitalization;Hospitals;human disease;Hyperammonemia;Hypotension;Hypoxia;imaging biomarker;Impaired cognition;Impairment;improved;insight;Intervention;Invaded;Knowledge;Lead;Link;Liquid substance;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measures;Mediating;Medical;mental state;Mentored Patient-Oriented Research Career Development Award;Mentors;Metabolic;Metabolism;metabolomics;Methodology;mid-career faculty;mind body interaction;Modeling;Morbidity - disease rate;mortality risk;Neurological outcome;Neurologist;Neurology;neurophysiology;Osmolalities;Osmolar Concentration;Outcome;Outcome Assessment;Pathologic;Pathway interactions;patient oriented research;Patient-Focused Outcomes;Patients;Physicians;Physiological;Physiological Processes;pressure;programs;prospective;prototype;Quality of life;Research;Research Methodology;Research Personnel;Research Proposals;research study;response;Risk;Risk Marker;Risk Reduction;Scanning;Scientist;Serum;Severities;skills;Study models;Survivors;Syndrome;Technical Expertise;Techniques;Time;Training;translational approach;United States National Institutes of Health;Universities;Vascular Cognitive Impairment;Vascular Dementia;Viral;Work;X-Ray Computed Tomography

PROJECT_TITLE: Cerebral Autoregulation, Metabolic derangement, and Edema in Encephalopathy Outcome (CAMEEO)

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Digestive Diseases;Lung;Nutrition;Pulmonary Hypertension;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Despite recent progress in medical therapy, current treatments for PH can only improve patients’ symptoms temporarily, and these patients often need lung transplant. This proposal will investigate the role of small intestine and lung in the pathogenesis of PH induced by oxidized lipids. We will delineate novel underlying mechanisms and exploit our mechanistic experimental design to develop new treatments for this disease.

PI_NAMEs: EGHBALI, MANSOUREH  (contact);REDDY, SRINIVASA T.

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Apoptosis;Bioinformatics;C57BL/6 Mouse;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell motility;Cells;Cessation of life;Chronic lung disease;Conditioned Culture Media;CXCL10 gene;cytokine;Data;data integration;Development;Diet;dietary;Dietary Supplementation;Disease;Endothelial Cells;Epithelial Cells;Epithelium;Experimental Designs;experimental study;Fatty Acids;Feedback;Functional disorder;Gene Chips;Genes;gut inflammation;Human;Hydroxyeicosatetraenoic Acids;Hypertension;Immune;Immune system;Immunohistochemistry;improved;Induction of Apoptosis;Inflammation;Inflammatory;Interferon Activation;Interferon Type II;Interferons;intestinal epithelium;Intestines;knock-down;Lamina Propria;Ligands;Lipoxygenase;Lung;Lung Transplantation;Mediating;Medical;Micro Array Data;Molecular;Mononuclear;Mus;new therapeutic target;novel;oxidized lipid;Pathogenesis;Pathologic;Pathway interactions;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Phase;Phenotype;Phospholipase;Plasma;Play;prevent;Production;Proteins;Publications;Publishing;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary Hypertension;pulmonary vascular remodeling;Rattus;Recombinants;Reporting;right ventricular failure;Rodent;Role;Small Intestines;Stimulus;Supporting Cell;Symptoms;T-Lymphocyte;Time;TNF gene;transcriptome sequencing;Up-Regulation;Wild Type Mouse

PROJECT_TITLE: Role of intestinal inflammation in oxidized lipid induced pulmonary hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Relevance Statement We will develop an innovative method to generate covalent protein binders for cell receptors. The success of this project will allow researchers to more effectively target proteins involved in various diseases including cancer for mechanistic studies, and may lead to a new generation of protein therapeutics.

PI_NAMEs: WANG, LEI  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Affect;Affinity;Amino Acids;anti-cancer research;Antibodies;Antineoplastic Agents;Binding;Binding Proteins;Biological Response Modifier Therapy;cancer cell;Cancer cell line;cancer therapy;Cell Physiology;Cell surface;Cells;checkpoint receptors;covalent bond;cytotoxic;cytotoxicity;Data;design;Development;Diagnostic;Dimensions;Disease;drug action;ERBB2 gene;Generations;Genetic;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;In Vitro;in vivo;innovation;Ligands;Malignant Neoplasms;Measures;Membrane;Methods;mouse model;nanobodies;novel;Pharmaceutical Preparations;Property;protein protein interaction;Proteins;Reaction;receptor;Receptor Cell;reconstitution;Research;Research Personnel;Side;Signal Transduction;small molecule;success;T-Cell Activation;technology platform;Therapeutic;therapeutic protein;Translating;tumor;tumor growth;tumor xenograft;unnatural amino acids;Xenograft procedure

PROJECT_TITLE: Covalent Protein Binders for Cancer Research and Therapy

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Diabetes;Genetics;Neurosciences;Nutrition;Obesity;Physical Activity;Prevention

PI_NAMEs: QI, NATHAN R. (contact)

PROJECT_TERMS: Animal Model;Animals;Anxiety;Area;bariatric surgery;base;Behavior;behavior test;Behavioral;behavioral phenotyping;Biological Assay;Blood;blood glucose regulation;Blood specimen;Blood Vessels;Body Fluids;Body Weight;Bolus Infusion;Cannulas;Closure by clamp;Collaborations;combat;Conscious;Consultations;Continuous Infusion;Continuous Intravenous Infusion;cost effective;Country;Culex (Genus);Data;Data Analyses;design;Diabesity;Diabetes Mellitus;dietary constituent;Disease;Educational workshop;Environment;Environmental Risk Factor;Equipment;Exercise Test;exercise training;experience;Experimental Designs;experimental study;Fatty acid glycerol esters;Fatty Acids;Feeding behaviors;Fiber;Fiber Optics;food consumption;Functional disorder;Genetic;Germ-Free;Glucose;Glucose Clamp;glucose metabolism;Glycerol;Goals;Habits;Home;Hormone secretion;Hormones;Human Resources;Hyperinsulinism;Hypoglycemia;in vivo;Indirect Calorimetry;Infusion procedures;Insulin;insulin sensitivity;interest;Isotope Labeling;Label;Laboratories;Learning;Lighting;lipid metabolism;Lipids;Lipolysis;Macronutrients Nutrition;Measurement;Measures;Memory;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;metabolic rate;Metabolism;metabolomics;Methodology;Michigan;microbiome;Mission;Modeling;Molecular;Monitor;Motor Activity;mouse model;Mus;Neurons;Nutrient;Obesity;Operant Conditioning;Operative Surgical Procedures;optogenetics;Paper;Parabiosis;Pattern;Performance;Phenotype;Photometry;Physiological;Physiology;Population;preference;Procedures;Process;Property;Protocols documentation;Radiolabeled;Reagent;Research;Research Personnel;Resources;respiratory;response;Role;Running;Sampling;Services;Stable Isotope Labeling;Standardization;Statistical Data Interpretation;Structure;Surgical Models;System;Taste Perception;Techniques;Technology;Testing;Time;Tissue Sample;Tissues;tool;Tracer;Training;training opportunity;Triglycerides;Universities;VO2max

PROJECT_TITLE: Core C: Phenotyping Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the formation of -amyloid plaques and tau neurofibrillary tangles, the latter of which correlates with dementia scores in patients. We will develop a novel class of disease-modifying drugs for the treatment of AD that will ultimately increase tau degradation to prevent tangle formation. We will accomplish this goal using state-of-the-art drug discovery approaches.

PI_NAMEs: OLSON, STEVEN H (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Acceleration;Affinity;aging population;Alzheimer's Disease;Alzheimer's disease patient;American;Amyloid beta-Protein;analog;Animal Model;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence method;Attenuated;Back;Behavioral;Binding;Biological Assay;Brain;cancer therapy;chemical property;Chemicals;Clinic;Clinical;Clinical Trials;Computer Assisted;Crystallization;Custom;Data;Dementia;design;Disease;Disease Progression;Dose;drug candidate;Drug Design;drug discovery;Drug Kinetics;Drug Targeting;effective therapy;efficacy study;efficacy testing;efflux pump;Elements;experience;extend lifespan;extracellular;Family;Farnesyl Transferase Inhibitor;farnesylation;Farnesylation Inhibition;functional group;Goals;Guanosine Triphosphate Phosphohydrolases;high throughput screening;Human;Human Development;Impaired cognition;in silico;in vivo;inhibitor;innovation;Knowledge;Laboratories;Lead;lead optimization;Legal patent;Libraries;Lonafarnib;Longitudinal Studies;Lysosomes;Malignant Neoplasms;Mediating;mouse model;Mus;neural network;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;neuron loss;neuropathology;new therapeutic target;novel;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacologic;Pharmacotherapy;pre-clinical;preclinical evaluation;prevent;Process;Property;protein degradation;Proteins;proteostasis;Public Health;Publishing;Pump;Reporting;Research;Research Design;Risk;Roentgen Rays;Senile Plaques;Small Interfering RNA;small molecule;small molecule libraries;Structure;tau aggregation;tau mutation;tau Proteins;Tauopathies;Testing;Therapeutic;Translating;Validation;virtual;Work

PROJECT_TITLE: Preclinical discovery of novel farnesyltransferase inhibitors for the treatment of Alzheimer's disease and related tauopathies

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Young-onset Alzheimer’s disease occurs in individuals who experience symptoms before the age of 65 and lack a known mutation. Using advanced neuropathology and transcriptomics technology, we seek to investigate why younger individuals suffer more significant accumulation of tau in neurons and more commonly report non-memory symptoms. Our scientific team has combined one of the largest series of young-onset Alzheimer’s disease brains to study, which will be critical for our evaluation of why certain brain regions and specific cells are vulnerable to changes in Alzheimer’s disease.

PI_NAMEs: GHETTI, BERNARDINO FRANCESCO;GRINBERG, LEA TENENHOLZ;MURRAY, MELISSA ERIN (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Affect;Age;Age of Onset;aging population;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease risk;Area;association cortex;Astrocytes;Basal Nucleus of Meynert;Biological;Brain;Brain region;cell type;Cells;Cellular biology;Cessation of life;cholinergic;Clinical;Cognitive;cohort;comorbidity;corticobasal syndrome;Data;demographics;Development;digital;digital pathology;Disease;disease heterogeneity;end stage disease;entorhinal cortex;Environment;Evaluation;experience;Gene Expression;Gene Expression Profile;glial activation;Goals;Grant;Heterogeneity;Hippocampus;Human;Individual;Inflammation;innovation;Investigation;Late Onset Alzheimer Disease;Lesion;Lewy Body Disease;locus ceruleus structure;Maps;Measures;Methods;Microglia;Modeling;Molecular;Molecular Profiling;Morphology;Mutation;Nature;Nerve Degeneration;Neurobiology;Neurofibrillary Tangles;neuroimaging;neuron loss;neuronal patterning;Neurons;neuropathology;neuroregulation;neurotoxicity;noradrenergic;Pathology;Pathway interactions;Pattern;Persons;Population;Primary Progressive Aphasia;protein expression;protein TDP-43;Public Health;Reporting;Research;Resources;Senile Plaques;Series;Severities;sex;single-cell RNA sequencing;Stereotyping;Stratification;Structure;Symptoms;Syndrome;tau aggregation;tau Proteins;Technology;Testing;Tissues;transcriptomics;Traumatic Brain Injury;Vulnerable Populations

PROJECT_TITLE: Investigating regional and cellular vulnerabilities to tau pathology in young-onset Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-W(02)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Duchenne/ Becker Muscular Dystrophy;Genetics;Human Genome;Muscular Dystrophy;Pediatric;Rare Diseases

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE This K01 proposal aims to elucidate how caspase-mediated nuclear pore complex trimming enables myogenesis over short time scales but drives muscular dystrophies over longer time scales. The non-apoptotic functions of caspases and the direct role of the nuclear pore complex in muscle biology are examined. More broadly, this project will reveal new nuclear transport-dependent proteins and pathways that are involved in the formation and deterioration of skeletal muscles.

PI_NAMEs: CHO, UKRAE  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Apoptosis;Apoptotic;Binding;Binding Proteins;Biological;Biology;Caspase;Cell Death;Cell Fractionation;Cell Nucleus;Cells;ChIP-seq;Chronic;Chronic Disease;Cleavage Under Targets and Release Using Nuclease;cofactor;Complex;coping;Cytoplasm;Data;Deacetylase;derepression;Deterioration;Disease Progression;Dissociation;Distal;Duchenne muscular dystrophy;endoplasm;endoplasmic reticulum stress;Equation;fascinate;Focal Adhesions;Foundations;gene repression;Genes;Genetic Transcription;Genome;genome-wide;Goals;Health;Homeostasis;Impairment;Individual;invention;Life;Life Cycle Stages;Limb structure;Limb-Girdle Muscular Dystrophies;Mass Spectrum Analysis;Mediating;Membrane;Mentored Research Scientist Development Award;mouse model;mRNA Export;Muscle;Muscle Cells;Muscle Development;Muscle Fibers;muscle stress;Muscular Atrophy;Muscular Dystrophies;Myoblasts;myogenesis;Myopathy;novel strategies;novel therapeutic intervention;Nuclear;Nuclear Export;Nuclear Pore Complex;nucleocytoplasmic transport;Nucleosomes;Outcome;Pathologic;Pathway interactions;Patients;paxillin;Peptide Hydrolases;Phenotype;pleiotropism;prevent;Process;promoter;Protein Biosynthesis;Proteins;Proteome;PTK2 gene;Regulation;Regulation of Proteolysis;Research;Risk;Role;Sarcoplasmic Reticulum;Signal Transduction;Site;Skeletal Muscle;Stress;stressor;Structure;System;Time;transcription factor;transcriptome sequencing;Tubulin;ZYX gene

PROJECT_TITLE: Caspase-mediated nuclear pore complex trimming in myogenesis and muscular dystrophies

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Mental Health;Mental Illness;Nutrition;Pediatric

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative This project will test the efficacy and 12 month follow-up of a family-based therapy that uses specialized exposure to bodily cues compared to family therapy that focuses on taking control of child refeeding. Preliminary data suggests that family therapy with exposure increases autonomous eating and reduced judgmental body evaluation. This study will determine if these changes are the mechanism for treatment changes.

PI_NAMEs: HILDEBRANDT, THOMAS B (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Abbreviations;Address;Adolescence;Adolescent;Aftercare;Age;aged;Anorexia Nervosa;Attitude;Awareness;Behavioral;Blinded;Body Weight;Child;Child Rearing;Chronic;Clinical;comparative efficacy;conditioning;confirmatory trial;Cost of Illness;Cues;Data;Data Analyses;depressive symptoms;Development;Distal;Eating;Eating Behavior;Eating Disorders;efficacy evaluation;efficacy study;efficacy testing;efficacy trial;Electrophysiology (science);Eligibility Determination;Etiology;Evaluation;experience;Exposure to;Extinction;Family;Family psychotherapy;feeding;follow-up;Food;food avoidance;Foundations;Health Care Costs;Impairment;improved;Intervention;Laboratories;Learning;learning extinction;longitudinal dataset;Measures;Mediating;Mediation;Mediator;Meta-Analysis;Modeling;novel;Occupations;Outcome;Participant;Pathology;Patients;Pharmaceutical Preparations;primary outcome;Protocols documentation;Public Health;Publishing;Randomized Controlled Clinical Trials;secondary outcome;Self Efficacy;severe psychiatric disorder;sex;Shapes;standard care;success;Symptoms;systematic review;Testing;Time;treatment adherence;treatment comparison;treatment effect;Treatment Efficacy;treatment response;Weight

PROJECT_TITLE: A Confirmatory Efficacy Study of Interoceptive Exposure for Adolescents with Low Weight Eating Disorders


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Ovarian Cancer;Patient Safety;Precision Medicine;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: Project Narrative Ovarian cancer recurrence affects more than 50% of ovarian cancer survivors; however, little is known about specific factors contributing to ovarian cancer recurrence risk. The proposed research project will identify recurrence patterns on a population level, and evaluate the associations of patient, clinicopathologic factors, and gene expression signatures with patterns of ovarian cancer recurrence and mortality. Information gleaned from this proposal may improve identification of patients at higher risk for ovarian cancer recurrence, thereby informing clinical decision-making and leading to alternative therapeutic strategies and patient follow-up.

PI_NAMEs: COLLIN, LINDSAY JANE (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Affect;Algorithms;Area;Asian;Award;biobank;Biological;biomarker development;biomarker driven;Biometry;Black race;brca gene;cancer diagnosis;cancer epidemiology;Cancer Etiology;Cancer Patient;Cancer Prognosis;cancer recurrence;Cancer Survivor;Carcinoma;career development;Categories;Characteristics;Classification;Clinical;clinical care;Clinical Data;clinical decision-making;clinical remission;clinical risk;Clinical Trials;clinically relevant;cohort;Communication;Computational Biology;Data;data analysis pipeline;Data Sources;data streams;Development;Diagnosis;Disease;Disease Management;Distress;Epithelial ovarian cancer;epithelial to mesenchymal transition;Event;experience;follow-up;Fostering;Foundations;Fright;Future;Gene Expression Profile;Gene Expression Profiling;genetic epidemiology;Genetic Markers;Germ Lines;Glean;Goals;Guidelines;high risk;Hispanic;Hospitalization;improved;Individual;Intervention;Knowledge;Leadership;Link;Malignant neoplasm of ovary;Malignant Neoplasms;Medical Records;Mentorship;Molecular;Morbidity - disease rate;mortality;multiple data sources;Operative Surgical Procedures;Ovarian;Pathology Report;patient biomarkers;Patient Care;patient prognosis;Patients;Pattern;Performance;personalized approach;Population;population based;Population Database;Probability;Prognosis;prognostic;Prognostic Marker;Publishing;Recurrence;Research;Research Personnel;Research Project Grants;Resources;Risk;Risk Assessment;Risk Factors;Serous;Source;Systemic Therapy;Therapeutic;Tissue Sample;Training;transcriptomics;Treatment Protocols;treatment response;tumor;United States;Update;Utah;Validation;Women's mortality;Work;World Health Organization

PROJECT_TITLE: Identifying factors associated with ovarian cancer recurrence using a population-based approach


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Genetics;Pediatric;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Transplantation

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative CHARGE syndrome is a complex of multiple congenital malformations including T cell Immunodeficiency that is caused by thymic hypo/aplasia, and CHD7 is the key gene in the etiology of CHARGE syndrome. Thymic epithelial cells (TECs) that arise from thymic epithelial progenitors (TEPs) and definitive endoderm (DE) are the major component of the thymic microenvironment to support T cell development. The purpose of this project is to determine the ability of CHD7 gene deleted human embryonic stem cells and induced pluripotent stem cells (iPSCs) from CHARGE patients to develop into DE, TEPs and TECs, and the ability of gene correction to enable the CHARGE iPSCs to develop into functional DE, TEPs and TECs to support T cell development from co-transplanted human hematopoietic stem cells in immunodeficient mice.

PI_NAMEs: LAI, LAIJUN  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Address;adult stem cell;Antigens;Architecture;Autoantigens;Autologous;Birth;Cell Therapy;Cells;CHARGE syndrome;Complex;Congenital Abnormality;congenital anomaly;CRISPR/Cas technology;Defect;Development;differentiation protocol;DiGeorge Syndrome;Disease;DNA Binding;Embryo;embryonic stem cell;Endoderm;epithelial stem cell;Etiology;gene correction;Gene Deletion;Gene Mutation;Genes;helicase;Hematopoietic stem cells;Heterozygote;Human;human embryonic development;human embryonic stem cell;human induced pluripotent stem cells;Immune response;Immune Tolerance;immunodeficiency;Immunodeficient Mouse;Impairment;In Vitro;in vivo;induced pluripotent stem cell;insight;knock-down;Knock-out;Laboratories;loss of function;Modeling;Molecular;Mouse Embryonic Stem Cells;Mus;Mutation;Nature;novel;Organ;Organogenesis;Pathogenesis;Patients;Protocols documentation;reconstitution;Reporting;Role;Somatic Cell;Source;Stem Cell Development;Supporting Cell;Syndrome;System;T-Cell Development;T-Cell Immunodeficiency;T-Lymphocyte;Techniques;Testing;thymic aplasia;Thymic epithelial cell;Thymic Tissue;Thymus Gland;thymus transplantation;transcriptome;Transplantation;treatment fees;Undifferentiated;Zebrafish

PROJECT_TITLE: Modeling and treating T cell immunodeficiency in CHARGE syndrome by ESC- and iPSC-derived thymic epithelial cells

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PHR: Narrative Autism spectrum disorder is an early onset, life-long disorder that affects approximately 1% of the population, and is defined by fundamental impairments in social communication and restricted or repetitive behavior or interests. This work focuses on understanding how dysfunctions in two autism-linked genes ANK2 and SCN2A affect neuronal function. This project will shed light on the cellular and molecular mechanisms that contribute to the disorder, and potentially identify new avenues for therapeutic intervention.

PI_NAMEs: BENDER, KEVIN J;JENKINS, PAUL MICHAEL (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Actins;Action Potentials;Affect;Amino Acids;ANK2 gene;ANK3 gene;Ankyrins;ASD patient;autism spectrum disorder;autistic children;Axon;Binding;Biochemical;Biological Assay;Brain;Calcium;Cell Adhesion Molecules;Collaborations;Collection;Communities;Complementary DNA;Confocal Microscopy;Cytoskeleton;Data;de novo mutation;Dendrites;Development;Disease;early onset;Electrophysiology (science);Etiology;Evoked Potentials;excitatory neuron;exome;exome sequencing;falls;Family;Family member;Functional disorder;Gene Family;Generations;Genes;genetic variant;Heterozygote;hippocampal pyramidal neuron;Human;human disease;Image;imaging approach;Imaging Techniques;Immunoprecipitation;Impairment;In Vitro;insight;interest;Ion Channel;Knock-out;Length;Ligation;Link;link protein;loss of function;member;Membrane;Modeling;Molecular;molecular array;Mus;Mutation;neocortical;Neurodevelopmental Disorder;neuronal excitability;Neurons;new therapeutic target;novel;Participant;Pathway interactions;Patients;Phenocopy;Play;Population;postsynaptic;presynaptic;Protein Isoforms;Publishing;Pyramidal Cells;repetitive behavior;risk variant;Role;scaffold;Scaffolding Protein;SCN2A protein;social communication;Sodium;Sodium Channel;Symptoms;Synapses;synaptic function;Synaptic plasticity;Testing;Therapeutic Intervention;transmission process;two photon microscopy;Variant;Visualization;voltage;Work

PROJECT_TITLE: Convergent mechanisms for neurodevelopmental disorder genes


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LOUISVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Patients often suffer from permanent neurological deficits due to secondary degeneration of axons after spinal cord injury and there are no effective therapies to treat these problems. The molecular mechanisms that cause secondary “bystander” axonal loss following spinal cord injury remain poorly understood; however, growing scientific evidence suggests a key role of calcium overload and neuroinflammation in this process. We will explore the role of aberrant store-operated calcium entry (SOCE) as mediating direct secondary “bystander” degeneration and indirectly by targeting SOCE in microglia.

PI_NAMEs: STIRLING, DAVID PAUL (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Afferent Neurons;Anti-Inflammatory Agents;Area;Axon;axon injury;axonal degeneration;behavior test;Biological Process;Blood;Breeding;Calcium;Cell Physiology;cell type;Chronic;Cicatrix;cytokine;cytotoxic;Data;drug repurposing;Drug Targeting;effective therapy;Environment;Event;experimental study;FDA approved;functional improvement;functional outcomes;glial activation;gray matter;Growth;Growth Factor;Histology;Homeostasis;Human;Image;Imaging Techniques;Immune;improved;in vivo;Inflammation Mediators;Inflammatory;inhibitor;Injury;innovation;intravital imaging;intravital microscopy;Knock-out;Knockout Mice;LoxP-flanked allele;Mediating;Mediator;Microglia;Molecular;Mouse Strains;Multiple Sclerosis;Mus;Myelogenous;Myeloid Cells;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neurologic Deficit;Neurological outcome;neurological recovery;Neuronal Injury;Neurons;neuroprotection;new therapeutic target;Nitrogen;novel;Outcome;Oxygen;Pain;Pathologic;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Play;preclinical study;prevent;Process;Production;Recovery;Recovery of Function;recruit;Reporter;Reporting;Research;response;Role;Secondary to;Signal Transduction;Site;Source;Spinal;Spinal Cord;Spinal cord injury;STIM1 gene;Stroke;Technology;therapeutic target;Time;Tissue Preservation;Tissues;two-photon;Visualization;Wallerian Degeneration;white matter;white matter injury;wound healing

PROJECT_TITLE: The role of SOCE in microglia and secondary degeneration after SCI

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: We live in an uncertain world in which events are often unpredictable, and so being able to appropriately modify our decision making relative to our own uncertainty regarding future rewards is crucial for survival. Malfunctions of behavior and emotion in uncertain contexts are associated with psychiatric disorders and maladaptive behavioral states, such as anxiety, risk-seeking, and drug-addiction, but to date the neuronal mechanisms of uncertainty-related behaviors, such as risk seeking, are poorly understood. We will assess the mechanisms of risky decision making and study how neuronal circuits give rise to risk seeking or avoidance.

PI_NAMEs: MONOSOV, ILYA E. (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Anatomy;Animal Model;Animals;Anxiety;Area;Attitude;basal forebrain;Basal Ganglia;Behavior;Behavior assessment;Behavioral;Behavioral Mechanisms;Brain;Brain Stem;clinically relevant;Cognition;cognitive control;Data;Decision Making;discounting;Disease;Dorsal;dorsal raphe nucleus;Drug Addiction;Electric Stimulation;Emotions;Event;experimental study;Future;Globus Pallidus;Goals;Grant;Habenula;Human;Lateral;Link;maladaptive behavior;Mediating;Mental Depression;Mental disorders;Monkeys;motivated behavior;Motivation;neural circuit;neuromechanism;neuronal circuitry;Neurons;neuroregulation;Outcome;Output;Pattern;Population;Primates;Process;Punishment;Research;Resolution;response;Rewards;Risk;Risk Behaviors;Signal Transduction;Testing;Time;transmission process;Uncertainty;Variant;Work

PROJECT_TITLE: Neural Circuits that Regulate Risk Seeking

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Clinical Research;Transplantation

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative In normal physiology, the repertoire of human T cells includes a 10% subpopulation that expresses two, rather than a single, T cell receptor (TCR), determining the antigenic reactivity of the cell. Despite the obvious implications for potentially unwanted heterologous reactivity, dual TCR T cells are largely unstudied, though we recently proposed the novel paradigm and provided evidence demonstrating that dual TCR expression is important in thymopoiesis and that dual TCR cells have exceptional ability to recognize ligands driving alloreactivity and autoreactivity. Research proposed in this application examines dual TCR T cells in mouse models and human transplant patients to define the mechanistic basis for the atypical thymic selection and antigen recognition properties of these cells with the goal of revealing important aspects of T cell biology relevant to transplantation and potentially identifying novel targets for development of innovative therapeutics to improve clinical transplant outcomes.

PI_NAMEs: MORRIS, GERALD PATRICK (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Acute Graft Versus Host Disease;Address;Alloantigen;Allogenic;Antigens;Autoantigens;Autoimmune Diseases;Automobile Driving;autoreactivity;B-Lymphocytes;Biology;Cell Therapy;Cells;Cellular biology;chronic graft versus host disease;Clinical;Complication;cross reactivity;Data;Development;Diabetes Mellitus;Disease;Dissection;Exhibits;flexibility;Frequencies;Goals;graft vs host disease;Hematopoietic Stem Cell Transplantation;Human;Hybrid Cells;Immunologics;improved;Individual;innovation;insight;Libraries;Life;Ligands;Link;Measures;Mediating;MHC Interaction;Modeling;mouse model;Mus;mutant;novel;novel strategies;Outcome;Pathologic;Patients;Peptide/MHC Complex;Peptides;Physiology;Proliferating;Property;receptor;Receptor Cell;receptor expression;reconstitution;Regulatory T-Lymphocyte;Reporter;Research;response;single cell sequencing;Specificity;System;T cell receptor repertoire sequencing;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Therapeutic;Thymus Gland;tool;TRA@ gene cluster;Transgenic Mice;Transplant Recipients;Transplantation;Variant;Work

PROJECT_TITLE: Dual TCR Expression Effects on Alloreactivity and Transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Breastfeeding, Lactation and Breast Milk;Contraception/Reproduction;HIV/AIDS;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

ORG_NAME: POPULATION COUNCIL

PHR: PROJECT NARRATIVE We plan to develop a pre-coital, on-demand fast dissolving insert (FDI) containing a safe and effective combination of a nonsteroidal contraceptive and a potent anti-HIV/STI agent to protect women from pregnancy and the sexual acquisition of HIV/STIs. We expect this unique product will be used by women who have concerns about side effects from hormonal contraceptives, infrequent sex, and risk of HIV/STI acquisition.

PI_NAMEs: ANGSANTIKUL, PAVIMOL  (contact);TELESHOVA, NATALIA

PROGRAM_OFFICER_NAME: CUMMINS, JAMES E

PROJECT_TERMS: Acceleration;Acids;adolescent woman;analog;Animal Model;Anti-Infective Agents;Anti-retroviral resistance;Antimicrobial Effect;Atopobium vaginae;Bacteria;Bacterial Vaginosis;Biological Assay;Biological Sciences;Breast Feeding;Breastfed infant;Buffers;Chlamydia;Clinical;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;cytotoxicity;Data;Dose;efficacy study;efficacy testing;efficacy trial;Enrollment;Evaluation;Event;Excipients;Female;Female Adolescents;Formulation;Freeze Drying;Gel;Genitourinary system;Goals;Gonorrhea;Health;High Pressure Liquid Chromatography;HIV;HIV resistance;HIV risk;HIV/STD;hormonal contraception;Human Herpesvirus 2;Human papilloma virus infection;improved;in vitro Assay;in vivo;Infection;Infection prevention;innovation;Intravaginal Administration;irritation;Lead;Lectin;Literature;Macaca;Macaca mulatta;male;manufacture;manufacturing process;meetings;Methods;Modeling;mouse model;Mus;Normal Range;novel;Oral;Oryctolagus cuniculus;Partner in relationship;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phase;phase I trial;pill;pre-Investigational New Drug meeting;preclinical development;Predisposition;Pregnancy;prevent;Prevention;Prevention trial;Property;Protocols documentation;prototype;Rattus;recurrence prevention;Risk;Risk Reduction;Safety;Seminal fluid;Series;sex;side effect;simian human immunodeficiency virus;sperm cell;systemic toxicity;Technology;technology development;Testing;Toxic effect;Toxicology;Tube;Vagina;vaginal fluid;Vaginal Gel;Viral;Viral Physiology;Virus;Virus Diseases;Woman;Women's Health;Work

PROJECT_TITLE: Novel pre-coital, non-hormonal multipurpose prevention technology (MPT)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BROOKINGS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: SOUTH DAKOTA STATE UNIVERSITY

ORG_STATE: SD

PHR: NARRATIVE This proposed Center Of Biomedical Excellence is relevant for public health because it will improve molecular and cellular mechanistic understanding of inflammatory processes. This work is relevant to the mission of NIH in that the fundamental knowledge of inflammation generated by the center, will provide new strategies for regulating inflammation in numerous disease states and inflammatory conditions.

PI_NAMEs: HOPPE, ADAM DAVID (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Acceleration;Animals;Area;Bioinformatics;Biological Sciences;Biomedical Research;Biotechnology;career;Cell Communication;Cell Death;Cell Physiology;Cells;Center for Translational Science Activities;Centers of Research Excellence;Cilia;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Communication;CRISPR imaging;Cytokine Signaling;Development;Disease;Education;Environment;Evaluation;Event;experience;Faculty;formative assessment;Fostering;Funding;Genes;Genetic Transcription;Genomics;Goals;Grant;Growth;Health;Human;immune cell infiltrate;improved;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;instrumentation;interdisciplinary approach;Investments;Knowledge;Labor Forces;Lymphangiogenesis;Lymphatic;Macrophage;Macrophage Cell Biology;medical schools;Mentors;Microscopy;Mission;model development;Molecular;next generation sequencing;Optics;Pathway Analysis;Pathway interactions;Performance;Personnel Management;Pilot Projects;Plants;Private Sector;Process;Program Research Project Grants;programs;Proteins;Proteomics;Public Health;Records;Regulation;Research;research and development;Research Personnel;Research Project Grants;Resolution;Resources;Role;senior faculty;Senior Scientist;Signal Transduction;South Dakota;success;synergism;Technology;Technology Transfer;tenure track;Tissues;TNF gene;Training Support;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;Translations;Ubiquitin;United States National Institutes of Health;Universities;University adminstration;Work

PROJECT_TITLE: BioSystems Networks and Translational Research - Insights into Inflammation (BioSNTR-II)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Architecture;Biomedical Research;career development;Center for Translational Science Activities;Centers of Research Excellence;Clinic;cohort;Collaborations;college;Communication;Communities;Compensation;Core Facility;Decision Making;Development;Educational process of instructing;Educational workshop;Ensure;Environment;Evaluation;Evaluation Research;expectation;Expenditure;experience;Faculty;Fostering;Foundations;Funding;Goals;Grant;Home;Human Resources;Immunology;Inflammation;Infrastructure;insight;Institution;Lead;Leadership;Mentors;Mentorship;National Institute of General Medical Sciences;Natural Sciences;Pilot Projects;Policies;Positioning Attribute;Postdoctoral Fellow;Preparation;Procedures;programs;Progress Reports;Publications;Recommendation;recruit;Regulation;Research;research and development;Research Personnel;Research Priority;Research Project Grants;Research Support;Resource Allocation;Resource Development;Resources;Science;Services;skills;South Dakota;Structure;success;symposium;Talents;Teacher Professional Development;Techniques;tenure track;Time;tool;Training;training opportunity;Translational Research;Travel;United States National Institutes of Health;Universities;University adminstration;Work;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Genetics;Muscular Dystrophy;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE This proposal will identify and characterize new epigenetic drug therapies for Duchenne muscular dystrophy (DMD). This proposal will also advance our understanding of the roles of epigenetic gene regulation in DMD. The proposed research is relevant to public health because this study will take advantage of three model systems, zebrafish, human cell lines, and rats, to advance potential new treatment options for DMD.

PI_NAMEs: MACK, DAVID LEE;MAVES, LISA  (contact)

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;Aftercare;Biological Models;Birth;Cell Line;Chromatin;chromatin modification;Clinical Trials;clinically relevant;Combined Modality Therapy;Defect;Development;Disease;drug discovery;drug efficacy;Drug usage;Duchenne muscular dystrophy;Dystrophin;Effectiveness;Embryo;epigenetic drug;Epigenetic Process;Event;Face;fetal;Functional disorder;functional outcomes;Future;Gene Expression;Gene Expression Regulation;gene therapy;gene-editing approach;Genes;Genetic Transcription;Goals;Histone Deacetylase Inhibitor;Human Cell Line;human induced pluripotent stem cells;improved;insight;Knowledge;Libraries;male;Maps;Modeling;Mus;Muscle;Muscle function;Muscular Dystrophies;muscular structure;Mutation;Myocardium;myogenesis;Myopathy;Neuromuscular Diseases;novel;novel therapeutics;Outcome Measure;Pathologic;Pathology;Patients;pharmacologic;Pharmacotherapy;Phenotype;Positioning Attribute;Pre-Clinical Model;preclinical evaluation;Process;Progressive Disease;Public Health;Rattus;Research;restoration;Role;Safety;screening;side effect;single cell genomics;Skeletal Muscle;small molecule;standard of care;targeted treatment;Testing;Transcriptional Regulation;transcriptome;Validation;Work;Zebrafish

PROJECT_TITLE: Three-model platform for understanding DMD epigenetic mechanisms and advancing small molecule therapies

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Lymphatic Research

PI_NAMEs: GONZALEZ HERNANDEZ, JOSE LUIS (contact)

PROJECT_TERMS: Access to Information;Acute-Phase Reaction;Adoption;Algorithms;Antibodies;Bar Codes;Binding;Biochemical;Bioinformatics;bioinformatics resource;bioinformatics tool;Biomedical Research;Cell Death;cell type;Cells;Cilia;Clustered Regularly Interspaced Short Palindromic Repeats;Cryoultramicrotomy;Data;Data Analyses;data integration;Data Set;deep sequencing;differential expression;experience;experimental analysis;Experimental Designs;Face;Frequencies;Funding;Future;Gene Expression;Gene Expression Profile;gene function;gene network;gene regulatory network;Genes;Genetic;Genetic Transcription;genome-wide;genome-wide analysis;Genomics;Goals;Individual;Inflammation;Inflammation Process;Inflammatory;innovation;insight;interactive tool;interdisciplinary collaboration;large datasets;Libraries;Lymphangiogenesis;Lymphatic;Macrophage;Measurement;Mediating;Meta-Analysis;Methods;Microscopy;Molecular;new technology;next generation sequencing;novel;optical imaging;Pathway Analysis;Pathway interactions;Pattern;Phenotype;Preparation;Printing;programs;Proteomics;Public Domains;Research Personnel;Research Project Grants;Resolution;response;screening;Series;single-cell RNA sequencing;Site;skills;Small RNA;Surveys;Techniques;Technology;Testing;Time;tissue repair;Tissue-Specific Gene Expression;Tissues;TNF gene;tool;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Translating;Translational Research;United States National Institutes of Health;Validation;whole genome;Work;wound

PROJECT_TITLE: Transcriptome & Networks Analysis Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PROJECT_TERMS: Acceleration;analysis pipeline;Attention;Biochemical;Biological Assay;Biological Sciences;Biomedical Research;Cell Death;Cell Line;Cell Physiology;Cell Separation;Cell Survival;Cells;Cellular Morphology;Cellular Structures;Centers of Research Excellence;Chimeric Proteins;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;CRISPR imaging;CRISPR interference;CRISPR screen;CRISPR/Cas technology;cytokine;deep sequencing;Development;Dose;endonuclease;Ensure;Evaluation;experience;Faculty;Fee-for-Service Plans;Flow Cytometry;Fluorescence;fluorescence imaging;Fluorescence Recovery After Photobleaching;Funding;gene complementation;Gene Expression;gene product;Generations;Genes;Genetic;Genome;Genomics;Genotype;graduate student;Guide RNA;high resolution imaging;Image Analysis;imaging capabilities;Immune;industry partner;Inflammation;Inflammatory;innovation;insertion/deletion mutation;insight;International;Knock-out;knockout gene;lentivirally transduced;Light;Link;live cell imaging;Macrophage;Mammalian Cell;Mediating;member;Methods;Microscope;Microscopy;Modification;Molecular Biology;molecular phenotype;novel;Oligonucleotides;Open Reading Frames;optical imaging;Optics;Organelles;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;phenome;Phenotype;Population;Postdoctoral Fellow;Principal Investigator;Production;Productivity;programs;Proteins;rapid technique;Research;Research Project Grants;Research Support;Resolution;Resources;response;Ribonucleoproteins;Schools;screening;Services;Signaling Protein;South Dakota;Speed;Stimulus;Students;Technology;tenure track;three-dimensional visualization;Time;TNF gene;tool;Training;Training Support;transcriptome;Translational Research;whole genome

PROJECT_TITLE: CRISPR-Image Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Social Determinants of Health

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: NARRATIVE The proposed prospective, four-parallel-arm, randomized controlled trial tests two theoretically driven strategies to improve weight and dietary outcomes in women and men with overweight or obesity who are attempting to lose weight: an environmental control strategy and an impulse control training strategy. This research addresses the oft-debated question of how to best optimize behavior change, and whether one should attempt to resist temptation in consistently inhibiting impulses or avoid temptation altogether in eliminating unhealthy options from the home environment.

PI_NAMEs: SALVY, SARAH-JEANNE  (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Address;Adherence;Affect;Age;Alcohol consumption;arm;Asthma;behavior change;Behavioral;Biometry;Body mass index;Body Weight decreased;Cardiovascular Diseases;Characteristics;clinically significant;Clinics and Hospitals;cognitive testing;cognitive training;cost;Cues;Data;demographics;Development;Diet;dietary;Dyslipidemias;Eating Behavior;Effectiveness;Enrollment;Environment;Ethnic Origin;evidence base;executive function;experience;Fatigue;Food;food environment;Fostering;four-arm study;Frequencies;Genetic;Health;Heterogeneity;Home;Home environment;Household;improved;Individual;Informal Social Control;innovation;Intervention;Life Style;Malignant Neoplasms;Mediating;Medical center;member;men;Modification;Muscle;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity risk;obesity treatment;Obstructive Sleep Apnea;Outcome;Overweight;Participant;Pathway interactions;Persons;Physical activity;Process;programs;prospective;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research;Self-control as a personality trait;sex;Site;skills;Smoking;Socioeconomic Status;Spanish/English;Testing;Training;United States;waist circumference;Weight;weight loss program;Weight maintenance regimen;Woman;women's outcomes;Work

PROJECT_TITLE: Evaluating environmental control (AVOID) and inhibitory control (RESIST) strategies to improve weight management outcomes

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Cancer

PHR: PROJECT NARRATIVE  Cancer occurs when cells acquire changes that convert them from a normal to malignant state. Apoptosis is a program of cellular suicide that eliminates damaged cells to prevent cancer; yet the body also turns on this program following chemotherapy and radiation treatments in order to kill cancer cells. Therefore, it is important to investigate the pathways that control apoptosis to understand how cancer occurs and should be treated.

PI_NAMEs: CHIPUK, JERRY EDWARD (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: Affinity;analog;Apoptosis;Apoptotic;BCL-2 Protein;BCL2L11 gene;Binding;Biochemical;Biological Models;biophysical techniques;Biophysics;Cancer Biology;cancer cell;Cancer Etiology;Cancer Model;cancer therapy;Carbon;Caspase;cell injury;Cell Membrane Permeability;cell suicide;Cells;cheminformatics;Chemoresistance;Chemotherapy and/or radiation;Classification;Clinical;Collaborations;Coupled;Cytoplasm;Data;Environment;Excision;experimental study;Family;Fibroblasts;Foundations;Human;insight;Knowledge;Laboratories;Lead;Lipids;Maintenance;Malignant Neoplasms;malignant state;Mediating;Melanoma;Mitochondria;mitochondrial membrane;Modeling;Molecular;Molecular Conformation;Mus;mutant;novel;novel therapeutic intervention;Outer Mitochondrial Membrane;Pathway interactions;Phase;Phenotype;prevent;Process;programs;protein activation;protein B;protein function;protein protein interaction;Proteins;Proteolipids;Radiation therapy;Regulation;Research;Resistance;Role;screening;sensor;small molecule;Sphingolipids;Stress;Structure;success;System;Techniques;Therapeutic;treatment response;tumor initiation;tumorigenesis;Validation;virtual screening;Xenograft procedure

PROJECT_TITLE: Function and Regulation of the BCL-2 Family

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Cystic Fibrosis;Digestive Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Cystic Fibrosis (CF) is the most common, life-shortening genetic disease, affecting approximately 30,000 persons in the U.S. and 100,000 persons worldwide. Defective bicarbonate secretion in CF contributes to the morbidity and mortality associated with this disease. My aim is to establish patient derived 3-dimensional duodenal enteroids which recapitulate native CF duodenal tissue’s bicarbonate secretory properties and identify new ways to circumvent defective bicarbonate secretion in CF.

PI_NAMEs: SELLERS, ZACHARY MICHAEL (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Affect;analog;Award;Bicarbonates;Binding;Binding Proteins;Biotinylation;career development;Cell membrane;Cell surface;Chlorides;Complement;cost;CRISPR therapeutics;CRISPR/Cas technology;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Defect;differential expression;Disease;Duodenum;Effectiveness;Ensure;Enterotoxins;Environment;enzyme activity;Escherichia coli;experience;experimental study;gastrointestinal;gene editing technology;Genetic Diseases;Genotype;Goals;Human;Immunofluorescence Immunologic;improved;In Vitro;inhibitor;Inositol;instructor;Intervention;Intestines;Ion Channel;Ion Transport;Knock-out;Life;lung failure;Malabsorption Syndromes;Measures;medical schools;Mentors;Modeling;Morbidity - disease rate;mortality;Mus;Mutation;novel;novel therapeutics;Nutrient;Organoids;Pancreatic enzyme;Pathogenesis;Pathway interactions;Patients;Pattern;Pediatrics;Persons;Pharmaceutical Preparations;pharmacologic;Phospholipase C;Physicians;Property;pulmonary function;putative anion transporter 1;receptor binding;Regulation;Research;Research Personnel;Role;Scientist;Signal Pathway;Site;SLC26A3 gene;small molecule;success;Surface;Techniques;Technology;Therapeutic;therapeutic target;Tissues;Titrations;tool;Traction;Training;Translational Research;tripolyphosphate;United States;Universities;Villus;VX-770;Western Blotting;Wine

PROJECT_TITLE: CFTR-Independent Bicarbonate Secretion is a Novel CF Therapeutic Target

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics

PI_NAMEs: THIEX, NATALIE WENDT (contact)

PROJECT_TERMS: 3-Dimensional;Actins;Animals;Anti-Inflammatory Agents;Antigen Presentation;Autoimmune Diseases;Biological Response Modifiers;Cell membrane;Cell Physiology;Cells;Centers of Research Excellence;Chimeric Proteins;chronic wound;CRISPR imaging;CRISPR/Cas technology;Data;Disease;drinking;Endotoxins;Equilibrium;extracellular;Extracellular Fluid;F-Actin;Fluorescent Probes;Frequencies;G Actin;Gene Expression Profile;Genes;Goals;Image;imaging approach;Immunoassay;Immunologic Receptors;Immunologic Surveillance;Inflammation;Inflammatory;inhibitor;innovation;insight;ITAM;ITIM;Knockout Mice;Knowledge;Laboratories;Ligands;live cell imaging;live cell microscopy;Macrophage;Macrophage Activation;Measures;Mediating;Mediator;Membrane;Metabolism;Microscopy;Modeling;Motility;Mus;novel;NR0B2 gene;Pathway Analysis;Phagocytosis;Phenotype;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Phosphotransferases;polymerization;Polymers;Process;promoter;recruit;Regulation;Research;Resolution;response;Rest;Role;Shapes;Signal Transduction;solute;spatiotemporal;stem;Stimulus;SYK gene;Techniques;Testing;therapeutic target;TLR4 gene;tool;tool development;transcriptome;Translational Research;TYROBP gene;uptake;Virus Diseases;whole genome;Work;wound healing

PROJECT_TITLE: SHP1 Phosphatase/SYK Kinase Balance Controls the Actin Economy and Macropinocytosis in Macrophages


ORG_CITY: DAVIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The National Center for Metabolic Phenotyping of Mouse Models of Obesity and Diabetes (MPMOD) at UC Davis will serve a primary role in providing unique, complex, and hard-to find tests and procedures for phenotyping live mouse models submitted by investgators from the biomedical research community. The MPMOD Center at UC Davis will also provide expertise, consultation, and advice to researchers on project planning, test selection, and outcomes measures. Further, the Center has proposed a partnership with Hispanic Serving Institutions as a component of the MPMOD Vibrant Program to enable underrepresented PIs and those from small research institutions that traditionally have not received significant research funding and/or have historically served under-represented populations to produce outstanding results and better compete for funding.

PI_NAMEs: LLOYD, KC KENT (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Acceleration;Adult;adult obesity;Age Years;aged;Animals;Anxiety;Attention;Autopsy;Awareness;bariatric surgery;Behavior;behavior test;behavioral phenotyping;Bioenergetics;Biomedical Research;Body Composition;Businesses;California;Cardiovascular system;Caring;Centers for Disease Control and Prevention (U.S.);Chronic stress;Client;clinically relevant;Communities;Complex;Consultations;Continuous Glucose Monitor;cost;Data;Data Analyses;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diagnostic;Disease;disease diagnosis;disease model;Eating;economic cost;energy balance;Energy Intake;Energy Metabolism;Environmental Risk Factor;Epidemic;Evaluation;Exercise;experience;Experimental Designs;experimental study;Feasibility Studies;Fee-for-Service Plans;Feeding behaviors;Fees;Food;Foundations;Functional disorder;Funding;gastrointestinal;Genetic;Gnotobiotic;Goals;Health;Heart Diseases;Heterogeneity;high risk;Hispanic-serving Institution;Histopathology;Human;Image;imaging capabilities;Impaired cognition;improved;In Vitro;in vivo;Incidence;Income;Infrastructure;innovation;Institution;International;Investments;Kidney;Learning;Macronutrients Nutrition;Malignant Neoplasms;Measures;member;Memory;Mental Depression;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;microbiome;Microsurgery;Modeling;Morbidity - disease rate;Motor;mouse model;Mus;Mutant Strains Mice;National Institute of Diabetes and Digestive and Kidney Diseases;neurobehavioral;Neurologic;neurophysiology;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Operative Surgical Procedures;Organ;Outcome Measure;Participant;Pathogenesis;patient population;Persons;Phenotype;Physical activity;Physiologic Thermoregulation;Physiological;Physiology;Pilot Projects;Plasma;Population;Positron-Emission Tomography;Prediabetes syndrome;Prevalence;Prevention;Prevention strategy;Procedures;Production;programs;Reporting;repository;Research;Research Personnel;Resources;respiratory;response;Role;Scientist;Serum;Services;Sleep;sobriety;Solid;Specialist;statistics;Stress;Stroke;success;Surgical Models;System;Technology;Testing;Therapeutic;Tissues;Training and Education;training opportunity;Translating;Translational Research;Underrepresented Populations;Universities;waiver;Writing


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Lymphatic Research

PI_NAMEs: FINK, DARCI M. (contact)

PROJECT_TERMS: Actins;Affect;Biological Assay;Biology;Blood;candidate identification;Carrier Proteins;Cell Line;Cell Physiology;Cell Polarity;cell type;Cells;Chemotaxis;Chronic;Cilia;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Cornea;Corneal Neovascularization;Data;Defect;density;Development;Diameter;Elements;Endothelial Cells;Erinaceidae;Event;Fluorescence;frontier;Future;gene-editing approach;Genes;Goals;Graft Rejection;Immune;In Vitro;in vitro Assay;in vitro testing;in vivo;Inflammation;innovation;insight;Intercellular Junctions;intravital imaging;KDR gene;Keratoplasty;Knock-out;Knockout Mice;Light;Liquid substance;lymph nodes;Lymphangiogenesis;Lymphatic;Lymphatic Diseases;Lymphatic Endothelial Cells;lymphatic vessel;Lymphedema;Lymphocyte;Microscopy;migration;Modeling;mouse model;Mus;new therapeutic target;next generation sequencing;notch protein;novel therapeutics;Ontology;Organelles;Pathology;Pathway Analysis;Pathway interactions;Pattern;Phase;Platelet-Derived Growth Factor alpha Receptor;prevent;programs;Proliferating;Proteins;Refractory;Regulation;Reporter;Research;Research Personnel;response;shear stress;Signal Pathway;Signal Transduction;Sorting;spatiotemporal;Structure;Surgical sutures;targeted treatment;Technology;Testing;therapeutic target;Time;Tissues;transcriptome sequencing;transcriptomics;Translational Research;tumor;Validation;Vascular Endothelial Growth Factor C;Work;wound healing

PROJECT_TITLE: Primary Cilia-Dependent Mechanisms of Lymphangiogenesis


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

PROJECT_TERMS: Accounts Payable;Animals;Awareness;Biology;Biomedical Research;Biometry;Businesses;Catalogs;Client;Communication;Communities;Consultations;cost;cost effective;cost effectiveness;Data;data management;Dedications;Deposition;Diabetes Mellitus;Effectiveness;Ensure;experience;Extramural Activities;Fees;Fostering;Funding;Goals;Head;improved;Income;Information Management;Institution;interest;Investments;Lead;Leadership;Link;Maintenance;Marketing;meetings;metabolic phenotype;mouse model;Mouse Strains;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Obesity;Online Systems;operation;outreach;Participant;Phenotype;phenotypic data;Play;Procedures;Process;Production;programs;Progress Reports;Protocols documentation;Provider;quality assurance;Quality Control;Records;Recovery;Reporting;Reproducibility;Research;Research Personnel;Resources;Role;Schedule;Scientist;service delivery;Services;Site;Standardization;Structure;success;synergism;Test Result;Testing;tool;Training and Education;United States National Institutes of Health;waiver;web site;Work