NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Leveraging rich data resources from seven well-characterized longitudinal cohorts, we propose to use a cutting-edge life course approach to determine the impact of objective and subjective sleep disturbances from different stages of life on cognitive trajectories across the life course. This novel research will help elucidate the role of life-course sleep disturbance as a prodromal or modifiable risk factor for Alzheimer's disease, which can directly inform the early detection of Alzheimer's and design of future sleep intervention trials. Moreover, the creation of a unique synthesized diverse cohort of life-course sleep and cognition will establish foundational resources for future research that aims to unravel the bi-directional link between sleep and Alzheimer's disease.

PI_NAMEs: LENG, YUE  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: actigraphy;Address;Adult;Affect;Age;Age-associated memory impairment;aged;Aged, 80 and over;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;biobank;Biological Markers;Black American;Blood Vessels;brain magnetic resonance imaging;cardiometabolism;Circadian Dysregulation;Circadian Rhythms;Clinical;Cognition;Cognitive;Cognitive aging;cognitive performance;cohort;Cohort Studies;Data;data harmonization;Data Pooling;data resource;dementia risk;design;Early Diagnosis;Early Intervention;emerging adult;follow-up;Functional disorder;Future;Genotype;Goals;high risk;Impaired cognition;Individual;innovation;Intervention;Intervention Trial;late life;Life;Life course epidemiology;Life Cycle Stages;Link;Longitudinal cohort;Measures;Mediating;Mexican Americans;middle age;modifiable risk;Nerve Degeneration;novel;older adult;Onset of illness;Outcome;Participant;Pathology;Pathway interactions;Pharmaceutical Preparations;Polysomnography;Population Heterogeneity;Prevention strategy;Process;Public Health;Race;Research;Research Methodology;Resources;Role;sex;sex variable;Sleep;Sleep Apnea Syndromes;Sleep disturbances;Sleeplessness;Statistical Methods;Symptoms;therapy design;Time;trend;Variant;Work;young adult

PROJECT_TITLE: Lifecourse sleep, cognitive decline and risk of Alzheimer's disease: a pooled cohort study.

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Rheumatoid Arthritis

ORG_CITY: New York

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

ORG_STATE: NY

PHR: PROJECT NARRATIVE In rheumatoid arthritis, the synovial lining is hyperplastic and primarily composed of activated fibroblasts that secrete multiple factors implicated in tissue damage. In this proposal we investigate mechanisms by which these fibroblasts are activated by components of the inflammatory microenvironment, including cytokines from infiltrating leukocytes, and how this activation results in their functional specialization. The identification of key, functionally relevant transcription factors and pathways will facilitate the development of fibroblast-directed therapeutics.

PI_NAMEs: SMITH, MELANIE HENNEBRY (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acceleration;Advisory Committees;Agonist;Anatomy;angiogenesis;Architecture;ATAC-seq;Automobile Driving;Biology;career development;Cartilage;Cells;Chemotaxis;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen;Confocal Microscopy;Coupled;CRISPR interference;CXCL1 gene;cytokine;Data;Data Set;Development;Doctor of Philosophy;Educational workshop;Environment;Epidermal Growth Factor Receptor;Exhibits;experience;Extracellular Matrix;Extracellular Matrix Degradation;Family;Fibroblasts;FOS gene;Funding;Gene Expression;Gene Expression Profile;Genes;Goals;Grant;Heterogeneity;Histologic;HLA-DR Antigens;Human;Hyperplasia;immune activation;Immunologics;Immunology;improved;In Situ;Inflammatory;inhibitor;innovation;Institution;Invaded;Investigation;Joints;Leadership;Learning;Leucocytic infiltrate;Leukocytes;Ligands;Lymphocyte;Measures;Mediating;medical schools;Medicine;Memorial Sloan-Kettering Cancer Center;Memory;Mentors;Mentorship;Methodology;Methods;MMP3 gene;neutrophil;New York City;Operative Surgical Procedures;osteoclastogenesis;Pathogenesis;Pathway interactions;Physicians;Process;professor;Program Development;programs;Publications;Receptor Activation;Receptor Signaling;Research;research and development;Research Personnel;response;Rest;Rheumatoid Arthritis;Rheumatology;Role;Signal Transduction;single-cell RNA sequencing;Site;skills;Special Hospitals;STAT1 gene;symposium;Synovial Fluid;Synovial Membrane;Synovitis;targeted treatment;Technical Expertise;Testing;Therapeutic;therapeutic target;Tissues;TLR2 gene;TLR4 gene;Toll-like receptors;Training;transcription factor;Transcription Factor AP-1;transcriptome sequencing;Writing

PROJECT_TITLE: Activation of Synovial Lining Fibroblasts in Rheumatoid Arthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Lung;Lung Cancer;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE: Immune checkpoint inhibitors, either alone or in combination with cytotoxic chemotherapy, are standard treatments for patients with metastatic lung cancer, yet less than half of patients will experience a reduction in size of their tumors and these responses typically last less than one year. This limited efficacy is in part due to an immunosuppressive fibrotic microenvironment characterized by impaired T cell function as well as dysfunctional antigen presentation. We will identify mechanisms by which TGFb inhibition in combination with chemotherapy can restore anti-tumor immunity to enhance immune checkpoint blockade.

PI_NAMEs: HERZOG, BRETT HOWARD (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Academic Medical Centers;Academic Training;Advisory Committees;Animal Model;Antigen Presentation;Antigens;Award;Biochemistry;Board Certification;Cancer Etiology;cancer immunobiology;cancer immunotherapy;Cancer Model;Cancer Patient;cancer therapy;cancer type;career;career development;Cell Physiology;Cells;checkpoint inhibition;checkpoint therapy;chemotherapy;Cicatrix;Clinical;clinical training;Clinical Trials;clinically relevant;Combination immunotherapy;Computational Biology;Cytotoxic Chemotherapy;Cytotoxic T-Lymphocytes;Data;Data Set;Dendritic cell activation;Dendritic Cells;Deposition;Desmoplastic;Development;Diagnosis;dimensional analysis;Disease;Doctor of Philosophy;driver mutation;Education;Elements;Environment;experience;Extracellular Matrix;feature selection;Fibroblasts;Fibrosis;fibrotic lung;Genetically Engineered Mouse;Goals;Grant;Hematology;high dimensionality;Human;human model;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immunity;Immuno-Chemotherapy;immunogenic cell death;Immunohistochemistry;Immunologic Surveillance;Immunotherapy;Impairment;improved;Internal Medicine;Laboratories;Lung Adenocarcinoma;Lung Neoplasms;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of thorax;Malignant Neoplasms;Mediating;Medical Oncology;Medicine;Mentors;Modeling;Molecular;Molecular Biology;Molecular Profiling;mortality;mouse model;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Oncology;Outcome;Ovalbumin;Patient Care;patient subsets;Patient-Focused Outcomes;Patients;Physicians;Population;pre-clinical;Pre-Clinical Model;Predisposition;Principal Investigator;Prognosis;prognostic;Program Development;programmed cell death ligand 1;programmed cell death protein 1;Pulmonary Fibrosis;Research Personnel;Research Project Grants;Resected;Resistance;response;Role;Sampling;Scientist;Signal Transduction;skill acquisition;standard care;synergism;T cell infiltration;T-Lymphocyte;Testing;Tissue Sample;Tissues;trafficking;Training;transcriptome sequencing;translational medicine;Translational Research;Treatment Efficacy;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;United States;Universities;Vocational Guidance;Washington;Work

PROJECT_TITLE: Lung fibrosis impairs tumor immunity and limits immune checkpoint efficacy

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative  For a number of age-related neurodegenerative diseases mitochondria alter their shape and become fragmented and dysfunctional. This proposal aims to establish a common mechanism by which mRNA localization and co-translational insertion drives mitochondrial dysfunction upon mitochondrial fragmentation.

PI_NAMEs: ZID, BRIAN MATTHEW (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: age related neurodegeneration;Aging;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-42;Appearance;Automobile Driving;Cells;Cytosol;Diffuse;Disease;DNA;DNA biosynthesis;DNA polymerase gamma;Goals;Heterogeneity;Homeostasis;human disease;Huntington Disease;Individual;insight;Investigation;Maintenance;Mammalian Cell;Measures;Messenger RNA;Microscopy;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial messenger RNA;Mitochondrial Proteins;Modeling;Morphology;mutant;Nerve Degeneration;Neurodegenerative Disorders;Noise;novel;Nuclear;Nuclear Proteins;Organelles;Orthologous Gene;Oxidative Phosphorylation;Parkinson Disease;Pathogenesis;Production;Protein Biosynthesis;protein expression;Proteins;Reaction;Research;Role;Shapes;Source;Structure;Surface;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;tool;Translations;Tubular formation;Work

PROJECT_TITLE: mRNA localization as a driver of mitochondrial dysfunction during neurodegeneration

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Immunotherapy;Nanotechnology;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE Cancer immunotherapy has become one of the major modalities for cancer treatment. Despite several cancer immunotherapies having been approved by FDA, many therapies fail to reach their potential due to the immunosuppressive tumor microenvironment (TME), including ovarian cancer. In this proposal, I will engineer viral nanoparticle to develop novel and effective multi-functional immunotherapies that are capable of reprograming the suppressive TME and restoring the natural immunity cycle to achieve effective treatment of ovarian cancer and prevent cancer recurrence.

PI_NAMEs: ZHAO, ZHONGCHAO  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Adjuvant;Advisory Committees;Agonist;anti-tumor immune response;Antigens;Biochemical;Biochemistry;Biology;Biomedical Engineering;cancer cell;cancer immunotherapy;Cancer Patient;cancer recurrence;cancer therapy;Capsid;career development;Cells;chemical conjugate;chemokine;chemotherapy;Clinical;Clinical Oncology;Clinical Research;clinical translation;Clinical Trials;Combination Drug Therapy;Combination immunotherapy;Combined Modality Therapy;Cowpea Mosaic Viruses;cytokine;design;Development;Diagnosis;Disease;Disease remission;doctoral student;Educational workshop;effective therapy;efficacy study;Encapsulated;Engineering;Enrollment;Faculty;FDA approved;Future;Genetic;Genetic Engineering;Goals;Grant;Hepatitis B Virus;Immune;Immune checkpoint inhibitor;Immunity;immunogenic;Immunology;Immunooncology;immunoregulation;Immunotherapy;Impairment;improved;in situ cancer vaccine;in situ vaccine;In Vitro;in vivo;Inflammatory;Innate Immune System;insight;Interleukin-12;Interleukin-2;Knowledge;Learning;Liposomes;Macrophage;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mentors;Messenger RNA;Modality;Modeling;mouse model;mRNA delivery;nanomaterials;nanomedicine;nanoparticle;nanoscale;nanotechnology platform;Natural Immunity;neoplastic cell;novel;Operative Surgical Procedures;Patients;Peptides;Phase;Plant Viruses;Pliability;Positioning Attribute;Postdoctoral Fellow;prevent;Production;programs;Protein Engineering;Reagent;receptor;Receptor Activation;Recurrence;Recurrent disease;Reporting;Research;Research Institute;Research Personnel;Research Technics;Secure;skills;standard of care;Structure;success;Survival Rate;synergism;System;tenure track;Therapeutic;TLR2 gene;Toll-like receptors;Training;Translational Research;treatment strategy;tumor;Tumor Antigens;Tumor Debulking;Tumor Immunity;tumor immunology;tumor microenvironment;tumor-immune system interactions;vaccine development;viral nanoparticle;Woman

PROJECT_TITLE: Engineering viral nanoparticles for TLR agonist-based multi-functional cancer immunotherapies

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Kidney Disease

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative: Idiopathic Nephrotic Syndrome (INS) is a devastating kidney disease for children, and the cause is unknown. Here we propose a novel role for the endothelial cell, a cell type that lines the inside of blood vessels. We will investigate the role of endothelial cells, and especially the endothelial molecule CD93, in INS using a combination of cell culture, animal models and human studies, with the goal of not only getting a better understanding of what causes the disease, but also potential ways to prevent or treat it.

PI_NAMEs: CARA-FUENTES, GABRIEL MIGUEL (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Adriamycin PFS;Advisory Committees;Affect;Age;Animal Model;Antibodies;authority;Autoantibodies;Binding;Biological;Biological Markers;Biological Process;Biology;Blood capillaries;Blood Vessels;career;career development;caveolin 1;Cell Culture Techniques;cell injury;Cell Line;Cell surface;cell type;Cells;Child;Childhood;Cicatrix;Circulation;Clinical;Clinical Research;clinically relevant;Coculture Techniques;Data;Development;Development Plans;Disease;Disease Progression;Disease remission;Dose;Electron Microscopy;Endothelial Cells;Endothelium;Etiology;experience;Experimental Models;Focal Adhesion Kinase 1;Focal and Segmental Glomerulosclerosis;Foot Process;Genes;glomerular endothelium;Glycocalyx;Goals;Heparitin Sulfate;Heterogeneity;Histologic;Human;Immunosuppressive Agents;In Vitro;in vivo;Injury;innovation;Integrins;Kidney;kidney biopsy;kidney cell;Kidney Diseases;Kidney Failure;Leadership;Mediating;Mediator;Mentors;Methodology;Modeling;nephrin;Nephrotic Syndrome;novel;Outcome;overexpression;Pathogenesis;Pathway interactions;Patients;Pattern;pharmacologic;Pilot Projects;podocyte;Population;precision medicine;predict clinical outcome;predictive marker;prevent;prognostic;Proteins;Proteinuria;Puromycin;Recombinants;Recurrent disease;Relapse;Renal function;Renal glomerular disease;Reporting;Research Personnel;Role;Serum;side effect;Signal Transduction;Source;Specificity;Surrogate Markers;syndecan;System;targeted treatment;Terminology;Testing;therapeutic target;Thrombomodulin;Time;Training;transcriptomics;treatment response;urinary;Urine;Work

PROJECT_TITLE: Evidence For Endothelial Involvement in Idiopathic Nephrotic Syndrome: A Role for CD93

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative This research seeks to understand how the structure of chondroitin sulfate glycosaminoglycans regulates protein recognition and signaling processes that underlie neuroplasticity, neuroinflammation, and axon remyelination. These processes play critical roles in neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis. As our studies take a distinctly chemical approach, this project may reveal novel therapeutic targets and strategies to stimulate plasticity, mitigate inflammation, and promote neuronal repair in response to aging, injury, and disease.

PI_NAMEs: HSIEH-WILSON, LINDA C (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Adolescence;Adult;Affect;Affinity;Aging;Alzheimer's Disease;Antibodies;Attenuated;Autoimmune Diseases;Axon;axon regeneration;Binding Proteins;Biological Process;Biology;Blocking Antibodies;Brain;Cell Differentiation process;Cell Maturation;Cells;Central Nervous System;central nervous system injury;Chemicals;chondroitin 4-sulfotransferase;Chondroitin Sulfate A;chondroitin sulfate glycosaminoglycan;Chondroitin Sulfates;Complex;conditional knockout;Development;Disease;Equilibrium;Extracellular Matrix;Family;Glycosaminoglycans;Goals;Grant;Hippocampus;Immune;immune activation;Immunity;Impairment;improved;in vivo;Inflammation;inhibitor;Inhibitory Synapse;Injury;insight;Invaded;Knockout Mice;Ligands;Malignant Neoplasms;Mediating;Memory;Mental disorders;Methods;mimetics;Molecular;Multiple Sclerosis;Mus;Natural Source;neural circuit;Neurobiology;Neurodegenerative Disorders;neuroinflammation;Neuronal Plasticity;Neurons;Neurophysiology - biologic function;neurotransmission;new therapeutic target;novel;novel strategies;novel therapeutic intervention;oligodendrocyte progenitor;optic nerve regeneration;Organic Chemistry;Pathogenicity;Pathology;Pattern;Permeability;Phenotype;Play;polarized cell;Polymers;Polysaccharides;polysulfated glycosaminoglycan;precursor cell;Process;programs;Proteins;receptor;Regulation;remyelination;repaired;Research;response;Role;Severities;Signal Pathway;Signal Transduction;social;spatiotemporal;Structure;Structure-Activity Relationship;Sulfate;sulfotransferase;Synapses;Synaptic plasticity;synaptogenesis;tool;Viral;Work

PROJECT_TITLE: Chemical approaches to understanding chondroitin sulfate glycosaminoglycans and their roles in brain plasticity and pathology

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative An increasing number of dually eligible individuals with Alzheimer's disease and related dementias (ADRD) continue to enroll in single-capitated or aligned D-SNPs for care coordination between Medicare and Medicaid services, but evidence for single-capitated or aligned D-SNPs improving outcomes is lacking. Our study will provide urgently needed information about the effects of single-capitated and aligned D-SNPs for dually eligible individuals with ADRD.

PI_NAMEs: KIM, HYUNJEE  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Abnormal coordination;acute care;Address;Adopted;Adoption;adverse outcome;Alzheimer's disease related dementia;Authorization documentation;beneficiary;care coordination;care fragmentation;care systems;caregiving;Caring;Characteristics;Chronic;Complex;Congresses;Data;Discipline of Nursing;dual eligible;Dual Enrollment;Effectiveness;Enrollment;Evaluation;evidence base;Expenditure;experience;Face;functional decline;Geography;Goals;Health;health care service utilization;Healthcare Systems;Impaired cognition;improved;improved outcome;Incentives;Individual;insight;Insurance;Insurance Coverage;Link;Long-Term Care;Managed Care Programs;Medicaid;Medicaid services;Medicare;Medicare claim;Medicare/Medicaid;meetings;Methods;Modeling;Outcome;Parents;payment;Persons;Policies;Policy Making;poor health outcome;Population;Poverty;Risk;Services;Special needs plan;System;Vulnerable Populations

PROJECT_TITLE: Long-term care integration for dually eligible individuals with Alzheimer's disease and related dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-P (91)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Immunotherapy;Nanotechnology;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: Los Angeles

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Public Health Relevancy Statement: The proposed research is intended to provide physicians with an entirely new molecular imaging tool that will essentially “paint” the tumor area that needs to be sensitively and specifically identified during and after surgical resection. We recently discovered that the FDA-approved dyes used for coloring of foods, drugs and cosmetics have a multitude of useful imaging properties that are ideal for incorporating into nanoparticles and could be used for highlighting tumors. This approach has great potential to be clinically translated and could significantly improve cancer detection, tumor resection, and identifying the most effective treatment options for the patient; thus, impacting overall therapeutic outcome.

PI_NAMEs: ZAVALETA, CRISTINA L. (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acceleration;Affinity;Antibody Avidity;antibody conjugate;Area;Binding;Biodistribution;Biological Markers;Cancer cell line;Cancer Detection;cancer imaging;Cancer Patient;cancer type;Cancerous;Candy;career development;Cell Culture Techniques;Cells;Characteristics;Charge;chemical conjugate;chemical property;Chemicals;Circulation;Clinical;clinical translation;Clothing;Color;contrast imaging;Contrast Media;Cosmetics;cost effective;CTLA4 gene;Curiosities;Decision Making;design;Drug Targeting;Dyes;effective therapy;Ensure;Epidermal Growth Factor Receptor;Esthetics;Excision;Extravasation;fabrication;Failure;FDA approved;Flow Cytometry;Fluorescence;fluorescence imaging;Food;Goals;Gold;Growth;Half-Life;Health Care Costs;Hispanic;Household;Human;human tissue;Image;image guided;Image-Guided Surgery;imaging approach;imaging capabilities;Imaging Device;imaging modality;imaging potential;imaging probe;imaging properties;Imaging technology;Immunotherapy;improved;In Vitro;in vivo;in vivo evaluation;individual patient;innovation;Ligands;Location;Malignant Neoplasms;Maps;Modeling;Molecular;Molecular Analysis;molecular imaging;Molecular Profiling;Monoclonal Antibodies;Morbidity - disease rate;mouth squamous cell carcinoma;Multimodal Imaging;multimodality;multiplexed imaging;Mus;nano;nanoparticle;novel;Operative Surgical Procedures;optical imaging;Optics;Outcome;overexpression;Paint;patient stratification;Patient-Focused Outcomes;Patients;Performance;Permeability;personalized medicine;Pharmaceutical Preparations;Physicians;Postoperative Period;pre-clinical;predicting response;Prediction of Response to Therapy;professor;programmed cell death protein 1;Property;Protein Analysis;Proteins;Public Health;Publishing;Repeat Surgery;Research;Resected;Resolution;Sensitivity and Specificity;Silicon Dioxide;Source;specific biomarkers;Surface;Surgeon;targeted biomarker;targeted treatment;tenure track;Testing;Therapeutic;therapy design;therapy outcome;Time;Toxic effect;Translating;treatment planning;Treatment Protocols;treatment response;treatment stratification;tumor;Tumor Debulking;tumor growth;Tumor Tissue;Visit;Xenograft Model

PROJECT_TITLE: A New Multimodal Molecular Imaging Approach to Guide Intra-Operative Tumor Resection and Post-Operative Treatment Planning


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Hospitalized Veterans and groups representing Veterans have voiced concerns with aspects of patient assisted mobility (i.e. being moved via the use of equipment and technology). The study aims to develop and validate the patient experiences of assisted mobility (PEAM) instrument. The measure will help VA better understand Veterans' experiences, identify ways to improve safety, comfort, dignity, and mobility. We will conduct interviews with staff and Veterans receiving care at rehabilitation units: spinal cord injury; hospital- based acute rehabilitation; and short-stay nursing homes. We will identify important characteristics informed by our conceptual model. We develop a survey, review with our advisory panel and Veterans, and administer the survey twice with 800 and 3500 Veterans, conduct observation assessment. Analysis at each stage will help refine the instrument. We will examine how well PEAM relates to similar constructs and outcomes for both individual and the units providing care.

PI_NAMEs: GUREWICH, DEBORAH  (contact)

PROJECT_TERMS: Acute;Address;Adverse event;Affect;Area;Assessment tool;Bariatrics;Benchmarking;care delivery;Caregivers;Caring;Characteristics;Clinical;clinical practice;Communication;Computerized Medical Record;Data;Data Collection;Decision Making;decubitus ulcer;Development;Devices;Dimensions;Disease;Education;Educational Materials;Effectiveness;Elements;empowerment;Ensure;Environment;Equipment;ergonomics;Evaluation;experience;Factor Analysis;Fall prevention;falls;Feedback;field study;Fright;functional independence;Future;Goals;Guidelines;Health;health care quality;Hospitalization;Hospitals;Human;improved;Individual;Infrastructure;Injury;innovation;Inpatients;insight;instrument;Intervention;Interview;Investments;Learning;Link;Long-Term Care;Managed Care;Measures;Medical center;Methodology;Methods;military veteran;Mobility decline;Modeling;Multiple Trauma;Nurses;nursing home length of stay;Outcome;Pain;Patient Monitoring;patient oriented;patient population;Patient Self-Report;Patient Transfer;Patient-Centered Care;Patient-Focused Outcomes;Patients;Perception;Performance;Personal Satisfaction;Persons;Physical activity;Policies;Population;pressure ulcer prevention;Privacy;Procedures;Process;Program Evaluation;programs;Property;Provider;Quality of Care;Recommendation;Recovery;Rehabilitation therapy;rehabilitative care;Reporting;Research Personnel;Resources;response;Risk;Role;safe patient;Safety;Sampling;Site;Spinal cord injury;Surveys;System;Tablets;Techniques;Technology;Telephone Interviews;Testing;theories;tool;Training;Training Programs;Variant;Veterans;Voice;Work

PROJECT_TITLE: Measuring Veterans' Safe Patient Handling and Mobility Experiences

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: ATLANTA

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Although brain and spinal circuits play important roles in recovery of walking after  stroke, if and how these circuits change in response to gait treatments is poorly  understood. This project will evaluate how two clinically- relevant rehabilitation  treatments change walking patterns, brain and spinal circuitry, and walking efficiency in  stroke survivors. By explaining why and for whom the treatments improve walking  function, this project will help develop more effective treatments that improve both  walking speed and walking quality, i.e. enable stroke survivors to walk faster and better.

PI_NAMEs: KESAR, TRISHA  (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Address;Ankle;Bilateral;Biological Markers;Biomechanics;Brain;Central Nervous System;Characteristics;Clinical;clinical investigation;clinically relevant;Communities;Compensation;Corticospinal Tracts;cost;Data;demographics;Development;effective therapy;Enhancing Lesion;follow-up;Foot-drop;functional electrical stimulation;Future;Gait;Gait abnormality;gait rehabilitation;Gait speed;Goals;Health;Impairment;improved;Individual;inter-individual variation;Intervention;kinematics;Kinetics;Knowledge;Leg;leg paresis;Lesion;Locomotion;locomotor control;Measures;Mission;Motor Cortex;motor learning;Movement;Muscle;National Institute of Child Health and Human Development;neural;neural circuit;Neurobiology;neuromechanism;Neuronal Plasticity;neuropathology;neurophysiology;novel;Output;Paresis;Participant;Patients;Pattern;Persons;Physical therapy;Physiological;Play;post stroke;Practice Guidelines;precision medicine;Primary Lesion;Randomized;Recommendation;Recovery;Rehabilitation Outcome;rehabilitation research;Rehabilitation therapy;response;Role;Speed;Spinal;spinal reflex;Stroke;stroke survivor;Testing;Time;Training;treadmill;treatment response;Walking;walking speed;Work

PROJECT_TITLE: Biomechanical and neural mechanisms of post-stroke gait training

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Orphan Drug;Patient Safety;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: DENTISTRY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative: Oropharyngeal cancer, which arises from precancerous oral lesions, will affect over 49,000 persons in the US during 2017. The best way to manage this deadly disease is to prevent transformation of the precancerous lesions. These studies will investigate drug releasing oral patches' abilities to return premalignant oral tissues to normal growth.

PI_NAMEs: MALLERY, SUSAN R (contact)

PROGRAM_OFFICER_NAME: WOJTOWICZ, MALGORZATA E

PROJECT_TERMS: 17p13;9p21;ABL1 gene;Address;Adverse effects;Adverse event;Affect;Affinity;Aftercare;Apoptosis;Basement membrane;Binding;Biological;Biological Markers;Biopsy;Black Raspberry;care costs;Cell Line;Cessation of life;Chemicals;Chemoprevention;Chemopreventive Agent;Chemotherapy and/or radiation;Clinical;clinical care;Clinical Trials;clinically relevant;cohort;Cytoskeleton;Data;Defect;Deformity;Deglutition;Dependence;Development;Disease;disorder control;Dose;Drug Kinetics;Eating;Economic Burden;Enteral;Enzymes;Epithelium;Esthetics;Evaluation;Event;Excision;exposure route;Face;Fenretinide;FHIT gene;Formulation;Fright;Gel;genomic locus;Goals;Growth;Heritability;Heterogeneity;high risk;Histology;Histopathologic Grade;Human;In Vitro;in vivo;Institutional Review Boards;Interferon alpha;Intraepithelial Neoplasia;Invaded;keratinocyte;large scale production;laser capture microdissection;Lead;Lesion;Liver;Loss of Heterozygosity;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;malignant oropharynx neoplasm;metabolic profile;Metabolism;meter;Methodology;Microscopic;migration;Modality;Modeling;Mole the mammal;Monitor;Mouth Sore;mouth squamous cell carcinoma;Nature;Night Blindness;Operative Surgical Procedures;Oral;oral cancer prevention;Oral cavity;oral cavity epithelium;oral lesion;Oral mucous membrane structure;Oral Surgical Procedures;oral tissue;Oryctolagus cuniculus;Participant;Patient Agents;Patient Compliance;patient subsets;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Phosphotransferases;pill;Polymers;preclinical study;premalignant;prevent;Prevention program;Prevention strategy;Prevention trial;programs;Proliferating;protein complex;Protein Tyrosine Kinase;Protocols documentation;prototype;PTK2 gene;public health relevance;Recurrence;Resolution;Saliva;side effect;Signal Transduction;Site;socioeconomics;Solid;Solid Neoplasm;Solubility;Squamous cell carcinoma;SRC gene;Standardization;STAT3 gene;stem cells;Surface;Surgical margins;Survival Rate;System;systemic toxicity;Therapeutic;Time;Tissues;Topical application;Toxicology;TP53 gene;treatment site;Tumor Suppressor Genes;UGT1A1 gene;uptake;Vitamin A

PROJECT_TITLE: Assessment of Chemopreventive Effects of a Mucoadhesive Fenretinide Patch on Premalignant Oral Epithelial Lesions

STUDY_SECTION: CDP

STUDY_SECTION_NAME: Chemo/Dietary Prevention Study Section[CDP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Overview: MDRO Carriage, Transmission, Sequelae, and Prevention in Nursing Homes  More than half of nursing home residents harbor at least one multidrug-resistant organism (MDRO) that can cause significant hard-to-treat infections. This program will combine epidemiologic, genomic, and simulation studies to comprehensively sample and study how five major MDROs spread in nursing homes between residents and the care environment, including in bedrooms and shared common areas. Findings will inform policy and identify high-yield infection prevention strategies to protect the 1.4 million people who reside in 15,000 U.S. nursing homes each year.

PI_NAMEs: HUANG, SUSAN S. (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: acute care;Address;Affect;Area;California;Candida auris;carbapenem resistant Enterobacterales;Caring;Centers for Disease Control and Prevention (U.S.);Characteristics;Communicable Diseases;Communities;community-level factor;comorbidity;Containment;County;Data;Disease;economic disparity;Ecosystem;effective intervention;Environment;Environmental Pollution;epidemiologic data;Epidemiology;Equipment;ethnic disparity;Evaluation;Extended-spectrum β-lactamase;fungus;genomic data;Genomics;Health;Health care facility;health economics;Healthcare;Home Nursing Care;hospital care;Hospitalization;Hospitals;Human;Human Microbiome;Individual;Infection;Infection prevention;Integration Host Factors;Intervention;Investments;Long-Term Care;Long-Term Care Nursing;Measures;medical vulnerability;Metagenomics;methicillin resistant Staphylococcus aureus;Methods;Microbiology;Modeling;models and simulation;Morbidity - disease rate;mortality;Multi-Drug Resistance;multi-drug resistant pathogen;multimodality;Nursing Homes;Oranges;Organism;Outcome;pathogen;pathogen genomics;Pattern;Persons;Policies;Population;Prevalence;Prevention;Prevention Guidelines;Prevention strategy;Program Research Project Grants;programs;prospective;racial disparity;Resistance;Risk;Risk Factors;Role;Route;Sampling;Science;simulation;Source;statistics;System;transmission process;United States;Vancomycin resistant enterococcus;Vancomycin-resistant S. aureus;wound


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

PHR: This study will directly impact the health and well-being of Veterans who have lost a lower limb due to Diabetic Peripheral Neuropathy (DPN). Over 20% of Veterans are diagnosed with diabetes, which makes it the second largest chronic disease population in the VHA. DPN is the most common complication associated with diabetes, and is responsible for about 62% of amputations among Veterans. The goal of this project is to reduce reports of phantom pain and improve overall health of the residual limb, thereby reducing the ongoing risk of complications from daily prosthesis use and loading imposed by the prosthetic socket. In parallel, we will enhance the balance, gait stability and activity levels of Veterans who have lost a limb due to DPN by providing feedback of foot-floor interactions via direct neural stimulation of the sensory nerves above the knee. We will achieve this adapting our successful approach to restoring perception of foot-floor contact that has already been demonstrated after traumatic limb loss to the specific clinical needs of Veterans with DPN.

PI_NAMEs: TRIOLO, RONALD J (contact)

PROJECT_TERMS: Address;Adverse event;Affect;afferent nerve;Amputation;Amputees;Anatomy;Attention;Biomechanics;Blood flow;Charge;Chronic;Chronic Disease;Circulation;Clinical;Clinical Trials;Communities;Complication;coping;Cutaneous;daily functioning;design;Diabetes Mellitus;diabetic;Diagnosis;Disease;Distal;Electrodes;Enrollment;Environment;Equilibrium;Equipment and supply inventories;Esthesia;Exhibits;fear of falling;Feasibility Studies;Feedback;Fiber;Floor;foot;Frequencies;functional outcomes;Funding;Gait;gait examination;General Population;Goals;Health;high risk;Home;Immunologics;Impaired healing;Implant;implantation;improved;improved mobility;Individual;innovation;Intervention;Intuition;Joints;Knee;Laboratories;Length;limb amputation;limb loss;Limb structure;Location;Lower Extremity;Measures;Mechanics;Medical;Nerve;neural;neural stimulation;neuroprosthesis;neuroprotection;novel;Operative Surgical Procedures;Oxygen;Pain;Participant;Pattern;Perception;Perfusion;Peripheral Nerves;Peripheral Nervous System Diseases;Personal Satisfaction;Phantom Limb Pain;Pharmaceutical Preparations;Physiological;Population;pressure;promote resilience;Prosthesis;prosthesis wearer;prosthetic socket;Psychophysics;Recording of previous events;recruit;Regulation;Reporting;residual limb;residual limb health;resilience;restoration;Risk;satisfaction;sciatic nerve;Sensory;sensory input;Severities;Site;Skin;Spatial Distribution;Surgical incisions;System;Temperature;Thigh structure;Time;Tissue Viability;Tissues;Translating;Veterans;volunteer;Walking;Weight;wireless

PROJECT_TITLE: Functional and Neuroprotective Effects of Restoring Lower Limb Sensation after Diabetic Peripheral Neuropathy

STUDY_SECTION: RRDD

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRDD]


PROJECT_TERMS: Awareness;Communication;Computer software;Dedications;design;Effectiveness;Ensure;Equipment and supply inventories;Ethics;Fostering;Future;Grant;Infrastructure;Interdisciplinary Study;Investigation;meetings;Monitor;multidisciplinary;National Institute of Allergy and Infectious Disease;Nursing Homes;Outcome;payment;Prevention;Process;Productivity;Program Research Project Grants;programs;Progress Reports;prospective;Public Health;quality assurance;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;Sampling;Schedule;Services;Site;Subgroup;synergism;transmission process;Vision

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Data Science;Emerging Infectious Diseases;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: WORBY, COLIN  (contact)

PROJECT_TERMS: analytical tool;Bioinformatics;Biomedical Research;Biometry;Catalogs;cloud based;Collaborations;Communicable Diseases;Complex;complex data;Computational Biology;computing resources;Consultations;Data;data access;data dictionary;data exchange;data hub;data management;Data Science;Data Science Core;Data Set;data sharing;Data Storage and Retrieval;Development;Ensure;Environment;epidemiologic data;Epidemiology;epidemiology study;Equipment and supply inventories;Evaluation;experience;genomic data;genomic epidemiology;Genomics;Goals;Infrastructure;innovation;insight;Institution;Leadership;metagenome;Methodology;Methods;microbial genomics;Modeling;multi-drug resistant pathogen;multidisciplinary;Nomenclature;novel;novel strategies;Nursing Homes;Output;pathogen genomics;Positioning Attribute;Prevention;programs;Prospective Studies;Research;Research Personnel;Research Project Grants;Resolution;Resources;Retrospective Studies;Sampling;Secure;Site;Software Tools;Statistical Models;statistics;success;Sum;synergism;terabyte;transmission process;Work

PROJECT_TITLE: Data Science and Statistics Core


NIH_SPENDING_CATS: Aging;Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Affect;Antibiotic Resistance;California;Candida auris;carbapenem resistant Enterobacterales;care delivery;Caring;clinically significant;combat;Communities;contagion;Containment;County;Data;Detection;Disease;economic disparity;effective intervention;Environmental Pollution;Epidemiology;ethnic disparity;Ethnic Origin;Extended-spectrum β-lactamase;Foundations;fungus;Goals;Guidelines;Health;health care disparity;health care settings;Hospitalization;Hospitals;Human;Individual;Infection;Infection prevention;Intervention;Investments;Knowledge;Length of Stay;Measures;medical vulnerability;methicillin resistant Staphylococcus aureus;Methods;Morbidity - disease rate;mortality;multi-drug resistant pathogen;Nursing Homes;Oranges;Outcome;pathogen;Persons;Policies;Population;Prevalence;prevent;Prevention;prospective;Prospective Studies;Public Health;Race;racial disparity;Resources;Retrospective Studies;Risk Assessment;Risk Factors;Sampling;screening;Site;Socioeconomic Status;Training;transmission process;trend;urgent and serious threat;Vancomycin resistant enterococcus;Vancomycin-resistant S. aureus;Vulnerable Populations

PROJECT_TITLE: Epidemiology of MDRO Carriage in Nursing Homes


NIH_SPENDING_CATS: Aging;Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Prevention

PI_NAMEs: EARL, ASHLEE MIRIAM (contact)

PROJECT_TERMS: Address;Admission activity;Candida auris;carbapenem resistant Enterobacterales;Caring;Circulation;Collection;Communities;Complement;connected care;cost effective;County;Data;Disease Outbreaks;Economics;Ecosystem;Environmental Pollution;epidemiologic data;Epidemiologic Methods;Epidemiology;Extended-spectrum β-lactamase;Future;genomic data;genomic epidemiology;Genomics;Goals;Health care facility;Healthcare;high risk;Hospitals;Human;Individual;Infection;Infection Control;Infection prevention;insight;Intervention;Logistics;Low Prevalence;Measures;metagenomic sequencing;Metagenomics;methicillin resistant Staphylococcus aureus;microbial;Modeling;Morbidity - disease rate;mortality;Multi-Drug Resistance;multi-drug resistant pathogen;multimodality;novel;Nursing Homes;Organism;pathogen;pathogen genomics;Pathway interactions;Pattern;Persons;Prevalence;Prevention;prospective;Prospective Studies;Recording of previous events;Resolution;Resources;Retrospective Studies;Risk Factors;Role;Sampling;Site;Source;Surface;surveillance strategy;Swab;transmission process;Vancomycin resistant enterococcus;Vancomycin-resistant S. aureus;Vulnerable Populations;Work

PROJECT_TITLE: Genomics of MDRO Transmission in Nursing Homes


NIH_SPENDING_CATS: Aging;Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Patient Safety;Prevention

PI_NAMEs: LEE, BRUCE Y (contact)

PROJECT_TERMS: Affect;Area;burden of illness;California;Candida auris;carbapenem resistant Enterobacterales;Cause of Death;Characteristics;Circulation;Clinical;comorbidity;Complex;Computer Models;County;Data;Data Analyses;Data Collection;economic impact;economic value;Economics;Ecosystem;Epidemiology;Equipment;Extended Spectrum Beta lactamase producing Enterobacterales;Goals;healthcare-associated infections;Individual;Infection Control;infection risk;innovation;insight;Integration Host Factors;Intervention;Long-Term Care Nursing;methicillin resistant Staphylococcus aureus;Modeling;multi-drug resistant pathogen;multimodality;Nursing Homes;Nursing Models;Oranges;Outcome;pathogen;Policies;Prevention;Principal Investigator;Research Personnel;Resources;synergism;Testing;Time;Translations;transmission process;Vancomycin resistant enterococcus;Vancomycin-resistant S. aureus;Work;wound

PROJECT_TITLE: Simulating the Spread and Control of Multiple MDROs Across a Network of Different Nursing Homes


FUNDING_MECHANISM: OTHERS

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: The decrease in serum ionized calcium and the increase in parathyroid hormone and c-telopeptide of type I collagen (a marker of bone formation) that occurs during exercise, referred to as a disruption in calcium homeostasis, may explain why bone does not always result in the expected exercise-induced increase in bone mass or why exercise may lead to bone loss under certain conditions. The disruption in calcium homeostasis has been well-characterized for acute endurance exercise, but the effects of resistance exercise and exercise training are less clear. The purpose of this study is to determine if resistance exercise results in a different bone biomarker response compared to endurance exercise, and if the disruption in calcium homeostasis is impacted by 10 weeks of endurance or resistance training. Blood samples will be collected before, during, and after the exercise training period for assessment of changes in markers of bone resorption and formation. Data will be used to develop future exercise interventions in older Veterans aimed at preserving bone health.

PI_NAMEs: WHERRY, SARAH J (contact)

PROJECT_TERMS: Acute;Address;Adult;aged;Aging;appropriate dose;Award;Biological Markers;Blood specimen;bone;Bone Density;Bone Formation Stimulation;bone health;bone loss;bone mass;bone preservation;bone quality;Bone Resorption;C-telopeptide;Calcium;cardiometabolism;Chronic;Collagen Type I;Cyclophosphamide;Data;design;disability;disabled;Dose;endurance exercise;Exercise;exercise intervention;exercise prescription;Exercise Test;exercise training;experimental study;fitness;Forteo;fracture risk;Frequencies;functional independence;functional outcomes;functional status;Future;Glean;Health;Hip Fractures;Homeostasis;hormone analog;Hormones;Hour;improved;innovation;Intervention;ionization;Knowledge;lifestyle intervention;Measures;men;Mentors;military veteran;mode of exercise;mortality;N-terminal;novel;older adult;older men;older women;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Outcome;Participant;Physical Performance;Population;preservation;Procollagen;PTH gene;Public Health;Quality of life;Randomized;Recommendation;Research;Resistance;resistance exercise;response;response biomarker;Risk Reduction;Role;Sampling;Serum;sex;Shapes;skeletal;Stimulus;Stress;Testing;Time;timeline;Type I Procollagen;Veterans;Visit;Walking;Weight Lifting;Woman;young adult

PROJECT_TITLE: Anabolic Versus Catabolic Skeletal Effects of Endurance or Resistance Exercise in Older Veterans

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Lung;Lung Cancer

PHR: NARRATIVE The grant application capitalizes on the advances in the adenosine receptor biology and understanding their roles in mediating cancer immunosuppression. It proposes clinical trial to test inhibition of A2B adenosine receptor with a specific antagonist PBF-1129 as a novel approach to enhance efficacy on anti-PD-1 immunotherapy. Animal studies are also proposed to understand the molecular mechanisms behind the regulation of anti-tumor immune responses by adenosine and metabolic tumor microenvironment.

PI_NAMEs: CARBONE, DAVID P. (contact);DIKOV, MIKHAIL M

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Ablation;Adenosine;Adenosine A2B Receptor;Adverse effects;Affect;Affinity;Animal Model;Animals;antagonist;anti-PD-1;anti-PD1 antibodies;anti-tumor immune response;Applications Grants;Biology;Biopsy;blood treatment;Cancer Model;Cancer Patient;Catabolism;Cell Differentiation process;Cell Fraction;Cells;checkpoint inhibition;chemotherapy;clinical application;Clinical Research;Clinical Trials;cohort;Collaborations;Combination immunotherapy;Combined Modality Therapy;Data;Dendritic Cells;design;Disease;Dose;ecto-nucleotidase;Effectiveness;efficacy evaluation;Enzymes;Evaluation;extracellular;Generations;Genetic;Growth;imaging approach;imaging modality;Immune;Immune checkpoint inhibitor;Immunity;Immunologics;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Impairment;improved;Institution;Magnetic Resonance Imaging;Malignant neoplasm of lung;Malignant Neoplasms;Maximum Tolerated Dose;Mediating;Metabolic;Metabolic stress;Methods;Modeling;Molecular;Myelogenous;Myeloid-derived suppressor cells;Natural Killer Cells;Nivolumab;Non-Small-Cell Lung Carcinoma;novel;novel strategies;novel therapeutic intervention;Outcome;Pathologic;Patients;PD-1 inhibitors;Peripheral Blood Mononuclear Cell;pharmacologic;Phase;Phase Ib Clinical Trial;Phase Ib Trial;Phenotype;phenotypic biomarker;pre-clinical;Preclinical Drug Evaluation;preclinical study;Probability;Productivity;programmed cell death protein 1;Proteins;Purinergic P1 Receptors;receptor;Receptor Inhibition;Receptor Signaling;Recommendation;Regulation;Regulatory T-Lymphocyte;Resistance;response;Role;Safety;safety assessment;Sampling;Shapes;Signal Transduction;Spain;stress reduction;T cell response;T-Lymphocyte;Testing;therapeutic target;Tissues;tumor;tumor growth;Tumor Immunity;tumor microenvironment

PROJECT_TITLE: Targeting immunosuppressive adenosine in patients with metastatic non-small cell lung cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Project Narrative The long-term goal of this research program is to develop innovative and meaningful chemical/synthetic biology tools and employ these tools to gain insights into biomedical processes for the development of novel therapeutics. The successful completion of the project is expected to open new avenues in biochemical study, prevention, and medical treatment of human diseases.

PI_NAMEs: GUO, JIANTAO  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Amino Acids;Area;Biochemical;Biological Process;Biology;Cells;Cellular biology;Chemicals;chemokine receptor;Co-Translational Protein Processing;Code;Codon Nucleotides;Development;Disease;Engineering;Future;Generations;Genetic Code;Goals;HIV-1;human disease;improved;innovation;insight;Investigation;Laboratories;Language;Mammalian Cell;Mediating;Medical;Mutagenesis;Nonsense Codon;novel;novel therapeutics;Organism;pathogenic bacteria;pathogenic virus;Post-Translational Protein Processing;Prevention;Process;programs;protein function;Proteins;Quadruplet Multiple Birth;receptor;Receptor Signaling;Research;Role;Signal Transduction;Sulfate;synthetic biology;targeted treatment;Terminator Codon;Therapeutic Agents;tool;Transfer RNA;Triplet Multiple Birth;tyrosine O-sulfate;Vaccines;virtual

PROJECT_TITLE: Developing synthetic chemical biology strategies for biochemical investigations and biomedical applications


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Narrative We will perform whole exome sequencing (WES) of prostate cancers from AA men to find additional molecular alterations associated with aggressiveness in African American (AA) men. We will also apply single-cell RNA- seq and mass spectrometry to prostate organoid cultures to characterize differences in the cellular states between ancestral backgrounds. Finally, we will validate the functional effects of ancestry- and grade-associated driver alterations in different ancestral backgrounds using novel prostate cell lines derived directly from patients.

PI_NAMEs: CAMPBELL, JOSHUA D (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: advanced disease;Affect;African American;African American population;Age of Onset;American;Biochemical;Biological;biological specimen archives;black men;Boston;Cancer Biology;cancer health disparity;candidate identification;cell growth;Cell Line;Cell model;Cells;Clinical;cofactor;cohort;Collection;Communities;Complement;CRISPR/Cas technology;Data;Death Rate;Diagnosis;Dimensions;Disease;Disparity;DNA Sequence Alteration;early onset;epidemiologic data;Epithelial Cells;ETV3 gene;European;Exhibits;exome sequencing;Fractionation;Genes;Genetic;Genome;genome editing;Gleason Grade for Prostate Cancer;Goals;Haplotypes;health care availability;high risk;improved;Incidence;Individual;innovative technologies;Invaded;Knowledge;Life;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Medical center;men;Meta-Analysis;Methods;Modeling;Molecular;mortality;mortality disparity;mortality risk;Mutation;novel;Oncogenes;Oncogenic;Organoids;Outcome;Pathway interactions;patient stratification;Patients;Population;Prostate;prostate cancer risk;Prostatectomy;Proteins;Proteomics;PTEN gene;racial disparity;racial population;Radical Prostatectomy;Reporting;Resources;response;single-cell RNA sequencing;Socioeconomic Status;Sorting;Specimen;System;Testing;therapy resistant;transcriptomics;tumor;Tumor Suppressor Proteins;United States;Validation;Work;ZFHX3 gene

PROJECT_TITLE: Investigating the mechanisms of driver genes associated with ancestry and aggressiveness in prostate cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative Our bodies are densely populated with the human microbiome that potently modulate immune system and hold tremendous promise as a new therapeutic for autoimmune disease, cancer and infectious disease. This project’s objective is to “decode” a high-resolution view of T cell induction by the gut microbiome by identifying a pair of bacteria-reactive T cell receptors and bacterial antigens. This project will provide insights to logically "design" a microbial community that works as a new therapeutic approach for inflammatory bowel disease and other devastating systemic disorders.

PI_NAMEs: NAGASHIMA, KAZUKI  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Advisory Committees;Anti-Inflammatory Agents;antigen-specific T cells;Antigens;Autoimmune Diseases;Award;B-Lymphocytes;Bacteria;Bacterial Antigens;bacterial community;bacterial genetics;Biological;cancer therapy;CD4 Positive T Lymphocytes;Cell Communication;Cell Line;Cell Physiology;Cells;Cellular biology;Coculture Techniques;Colitis;Communicable Diseases;Communities;Complement;Complex;design;Disease;Dropout;Drops;Ecosystem;Epitopes;Escherichia coli;fecal transplantation;Feces;Gene Cluster;genetic signature;Germ-Free;Goals;gut microbiome;gut microbiota;host-microbe interactions;Human;Human Microbiome;Hybridomas;Immune;immune function;Immune response;Immune system;Immunologics;Immunology;immunoreaction;immunoregulation;improved;in vivo;Individual;Inflammatory;Inflammatory Bowel Diseases;insight;Interleukin-10;Knowledge;Libraries;Logic;Malignant Neoplasms;medical specialties;member;Mentors;Mentorship;Metabolic Diseases;Metagenomics;Methods;MHC antigen;Microbe;microbial;microbial community;Microbiology;microbiome;microbiome components;microbiota;Modeling;Molecular;Molecular Biology;mouse model;Mus;neglect;new technology;novel therapeutic intervention;novel therapeutics;Paper;Pattern;Peptide Library;Phenotype;Physiological;predictive tools;programs;rational design;Regulatory T-Lymphocyte;Reporting;Research;Resolution;response;Role;screening;Shotguns;Signal Transduction;single cell technology;single-cell RNA sequencing;Site;Stimulus;T cell response;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Taxonomy;TCR Activation;Technology;Testing;Therapeutic;Therapeutic Effect;three dimensional structure;Time;tool;Training;Variant;Work

PROJECT_TITLE: Decode and design T cell induction by a complex gut microbial community

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative The overall purpose of this study is to increase the enrollment of marginalized communities disproportionately affected by HIV into early-stage preventive HIV vaccine trials. Using community-based participatory research approaches and informed by our COVID-19 work, we will co-refine, test, and evaluate an existing media campaign and develop a multilevel communication strategy. The study will identify critical factors and strategy components that impact HIV vaccine trial registration and determine if the strategy effectively addresses misinformation about vaccines and vaccine trials.

PI_NAMEs: ANDRASIK, MICHELE PEAKE (contact);SOUTHWELL, BRIAN G.

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: Address;Advertising;Affect;Awareness;Behavioral;Black, Indigenous, People of Color;Classification;clinical research site;clinical training;Collaborations;combat;Communication;Communities;community based participatory research;community engagement;community partnership;COVID-19;COVID-19 pandemic;COVID-19 Prevention Network;COVID-19 vaccine;Data;design;Development;Dissemination and Implementation;early phase trial;Educational Curriculum;Effectiveness;efficacy testing;Electronic Mail;eligible participant;Enrollment;equity, diversity, and inclusion;evidence base;experience;Facebook;Focus Groups;forging;Funding;Future;Goals;Government;Health;health communication;Health Services;HIV;HIV vaccine;HIV Vaccine Trials Network;implementation research;improved;innovation;Instagram;International;Interruption;Knowledge;Lesbian Gay Bisexual Transgender Queer;Longterm Follow-up;marginalized community;Marketing;Measures;Media Campaign;Medical Research;Misinformation;Modeling;multidisciplinary;Outcome;outreach;Participant;participant enrollment;Patient Recruitments;Performance;Phase;Phase III Clinical Trials;Population Heterogeneity;Positioning Attribute;Preventive;primary outcome;programs;Protocols documentation;Published Comment;recruit;Registries;Research;Research Personnel;Series;seropositive;social media;social stigma;Surveys;Taxonomy;Testing;Time;Training;trend analysis;trial enrollment;Trust;trustworthiness;Twitter;United States;Vaccine Clinical Trial;vaccine hesitancy;vaccine trial;Vaccines;virtual;Visit;web site;Work

PROJECT_TITLE: Evaluating a Multilevel Communication Campaign to Increase HIV Vaccine Trial Enrollment


ORG_CITY: MINNEAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE: Osteoarthritis is the nation's most common cause of disability. Meniscal root tears are increasingly recognized as the root cause of OA and considered a previously unrecognized ‘silent epidemic’. Unfortunately, current clinical MRI, even at 3T fails to accurately inform treatment decisions. Utilizing higher resolution imaging and quantitative tissue characterization at 7T will improve pre-operative assessment and thus postsurgical outcomes. The aim of the proposed work is to develop the technology needed to unleash 7T UHF (ultra-high magnetic fields) to its full clinical potential.

PI_NAMEs: ELLERMANN, JUTTA M (contact);METZGER, GREGORY JOHN

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;absorption;Acceleration;accurate diagnosis;Adoption;anatomic imaging;Anatomy;arterial spin labeling;Arthritis;articular cartilage;Bilateral;Biochemical;Biomedical Research;Blood Vessels;bone;Brain;Cartilage;Clinical;clinical care;clinical imaging;Data;Degenerative polyarthritis;density;Detection;Development;diagnostic accuracy;Diagnostic Imaging;disability;Disease Management;Disease Marker;Early Diagnosis;Engineering;Epidemic;Evaluation;FDA approved;Functional Imaging;Functional Magnetic Resonance Imaging;Future;Goals;Head;healthy volunteer;high resolution imaging;Hip region structure;Horns;Image;imaging approach;imaging modality;improved;innovation;instrument;Joints;Knee;Knee bone;Knee Injuries;Knee joint;longitudinal, prospective study;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measures;Medial meniscus structure;Medical;meniscal tear;Meniscus structure of joint;Methodology;Methods;Minnesota;molecular marker;Morphology;Musculoskeletal;Musculoskeletal Diseases;musculoskeletal imaging;Noise;novel;operation;Operative Surgical Procedures;Orthopedics;Outcome;Pathology;Pathway interactions;Patients;Perfusion;Pilot Projects;Predisposition;protocol development;Protocols documentation;Radial;reconstruction;repaired;Research;Resolution;RF coil;routine imaging;Scheme;Signal Transduction;Sodium;Spin Labels;structural imaging;subchondral bone;Surgeon;System;Techniques;Technology;technology development;temporal measurement;Testing;Time;Tissues;tool;Translating;translational study;transmission process;Universities;Validation;Work

PROJECT_TITLE: Advanced 7 Tesla imaging of the knee for root cause of Osteoarthritis

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Contraception/Reproduction;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: NARRATIVE Hypertensive disorders of pregnancy are a leading cause of maternal morbidity and mortality in the United States. Current interventions to prevent these disorders are extremely limited and minimally effective. The goal of this randomized clinical trial is to leverage ecological momentary assessment, wearable ambulatory biosensor, and electronically activated recorder technology to understand the mechanisms through which prenatal mindfulness training reduces risk for hypertensive disorders of pregnancy.

PI_NAMEs: BUBLITZ, MARGARET  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Acceleration;Adult;Affect;Affective;American Heart Association;Arteries;Biological Markers;Biosensor;Blood Pressure;blood pressure reduction;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Clinical Trials;Dementia;Disease;Doppler Ultrasound;Ecological momentary assessment;Educational Intervention;Educational process of instructing;Etiology;Exclusion;Exhibits;experience;Exposure to;Fetal Growth;Financial cost;follow-up;Gender;Goals;Healthcare Systems;heart disease prevention;heart disease risk;Heart Rate;heart rate variability;Hematological Disease;High Risk Woman;Hour;Hypertension;improved;in vivo;Infant;innovation;insight;Intervention;lifetime risk;Link;Loneliness;Lung Diseases;maternal morbidity;Maternal Mortality;Measures;Medical;Methodology;Methods;Mind-Body Intervention;mindfulness;mindfulness intervention;Mindfulness Training;Monitor;mortality;Mothers;National Heart, Lung, and Blood Institute;negative affect;Nonpharmacologic Therapy;novel therapeutic intervention;Participant;Pathway interactions;Patients;Physiologic Monitoring;Physiological;Pregnancy;pregnancy disorder;pregnancy prevention;Pregnant Women;prehypertension;prenatal;prevent;Prevention strategy;Process;psychologic;Randomized;randomized, clinical trials;Relaxation;Resistance;response;Risk;Risk Reduction;Sampling;smartphone application;Stress;stress management;Technology;Telephone;Testing;theories;treatment as usual;United States;Uterus;wearable device;wearable sensor technology;Woman;Wrist

PROJECT_TITLE: Mechanisms of mindfulness training to prevent hypertensive disorders of pregnancy

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Autoimmune Disease;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Genetics;Human Genome

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Our proposal leverages unique NIDCR-funded resources by utilizing existing infrastructure and an expanded team with high level expertise to better understand the pathogenesis of Sjögren's syndrome and identify therapeutic pathways, and new biomarkers. We propose to enhance the Sjögren's International Collaborative Clinical Alliance (SICCA) biorepository/registry by generating genome-wide DNA methylation and transcriptomic data that will enable high impact studies of underlying biologic pathways of SS both by our team and through an expanded dissemination plan that can leverage these enhanced data sets.

PI_NAMEs: SHIBOSKI, CAROLINE HELENE (contact)

PROGRAM_OFFICER_NAME: MELILLO, AMANDA A

PROJECT_TERMS: Advisory Committees;American;Autoimmune biomarker;biobank;Biological;Biological Markers;Biological Process;Biological Specimen Banks;Biopsy;Cells;Classification;Clinical;Clinical Data;Clinical Trials;cohort;Collaborations;college;Communities;Data;data repository;Data Set;data standards;database of Genotypes and Phenotypes;Development;Diagnosis;Disease;Disease Outcome;Disease Progression;DNA Methylation;Epidemiology;Epigenetic Process;epigenome;Etiology;European;follow-up;Funding;Future;Gene Expression;Generations;Genes;Genetic;genetic epidemiology;Genetic Heterogeneity;Genetic study;genome wide association study;genome-wide;Genomics;Genotype;Geography;Growth;Hereditary Disease;Hypergammaglobulinemia;Immune response;Immunology;improved;Infrastructure;insight;International;Labial Salivary Gland;Laboratories;Lymphocyte;Messenger RNA;Methods;Methylation;MicroRNAs;Modification;Molecular;National Institute of Dental and Craniofacial Research;next generation;novel marker;Participant;participant enrollment;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Pharmacotherapy;Phenotype;phenotypic data;Population Heterogeneity;Positioning Attribute;Process;promoter;Protocols documentation;Registries;repository;Research;Research Design;Research Personnel;Resources;response;Rheumatism;Rheumatology;Salivary Gland Tissue;sample collection;Sialadenitis;Signs and Symptoms;single cell mRNA sequencing;Sjogren's Syndrome;Specimen;Standardization;Structure of germinal center of lymph node;success;Therapeutic;Time;Tissues;transcriptome;transcriptomics;treatment research;United States National Institutes of Health;Validation;whole genome;Work

PROJECT_TITLE: Sjögren's International Collaborative Clinical Alliance Next Generation Studies (SICCA-NextGen)


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Fatal opioid overdose is a leading cause of preventable death in the United States, and more than 60% of drug overdose deaths are associated with fentanyl and its analogs. Advancing our understanding of the neural mechanisms underlying fentanyl seeking may facilitate the development of novel treatments for fentanyl use disorder and reduce fentanyl overdose deaths. This proposal aims to provide valuable insight into the neurobiological mechanisms underlying fentanyl-seeking behavior and the novel application of glucagon-like peptide 1 receptor agonists as a potential treatment for fentanyl use disorder.

PI_NAMEs: HERMAN, RACHEL JASCHIK (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Abstinence;Acute;addiction;Agonist;analog;Animal Model;Attenuated;Behavior;Brain;Brain region;Calcium;career;Cell Nucleus;cell type;Development;Enterobacteria phage P1 Cre recombinase;Epidemic;exenatide;Exposure to;Fellowship;Female;Fentanyl;fentanyl abuse;fentanyl overdose;fentanyl seeking;fentanyl self-administration;fentanyl use;fentanyl use disorder;Fiber;FOS gene;Foundations;Future;gamma-Aminobutyric Acid;GLP-I receptor;glucagon-like peptide 1;Goals;Implant;in vivo;in vivo calcium imaging;incretin hormone;Injections;insight;interpeduncular nucleus;male;Measures;Mediating;mesolimbic system;Modeling;Morphine;neural;neural circuit;neurobiological mechanism;Neurobiology;neuromechanism;Neurons;Neuropeptides;Neurosciences;novel;novel therapeutics;Opioid;opioid mortality;opioid overdose;Opioid Receptor;opioid use disorder;optical fiber;Overdose;overdose death;Pathway interactions;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacotherapy;Photometry;Pilot Projects;Play;Prevalence;prevent;preventable death;Public Health;Rat Transgene;Rattus;receptor;Relapse;Research Personnel;Rewards;Role;Saline;Self Administration;sensor;social stigma;Substance Use Disorder;synthetic opioid;Technical Expertise;Testing;Time;Training;United States;Withdrawal;Work

PROJECT_TITLE: A Novel Role of Interpeduncular Nucleus GLP-1Rs in Fentanyl Reinstatement


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: New technologies are revealing an unprecedented view of patterns of brain activity and brain connectivity. These data are extraordinarily complex, and computational and theoretical methods to analyze and interpret them lag far behind. Our training program will provide students and postdoctoral trainees with mentored training that connects computation and experiment with the skills to bridge fields using collaborative and reproducible analytical approaches.

PI_NAMEs: BUFFALO, ELIZABETH A (contact);FAIRHALL, ADRIENNE L;SHEA-BROWN, ERIC TODD

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Cognition;neural circuit;Training

PROJECT_TITLE: Training in theoretical and computational approaches to neural circuits of cognition


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Hot flashes and night sweats are associated with fluctuating estrogen levels during the menopausal transition but it is unclear how changes in estrogen signaling lead to hot flashes. We hypothesize that estrogen signaling alters temperature regulation through a region of the hypothalamus that is temperature-sensitive, rich in estrogen receptor expression, and controls heat dissipation and generation. The proposed studies will dissect the effects of estrogens on this thermoregulatory center and identify estrogen-dependent cellular mechanisms that may provide new targets for future therapies against hot flashes.

PI_NAMEs: CORREA, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Ablation;adenovirus mediated delivery;Affect;Apoptosis;associated symptom;Automobile Driving;Blood Vessels;body cavity;Body Temperature;Brain;Calcium;Cells;Custom;Data;designer receptors exclusively activated by designer drugs;DNA;Engineering;ESR1 gene;Estradiol;Estrogen Receptors;estrogenic;Estrogens;experimental study;Exposure to;Feeling;Fiber;Future;Gene Expression;Gene Expression Profile;gene function;Generations;Genetic;Genetic Transcription;Goals;Health;Hot flushes;Hypothalamic structure;Image;Implant;improved;in vivo;Knowledge;Label;Lead;Ligands;loss of function;Maps;Measures;Medial;Mediating;Menopausal Symptom;Menopause;Metabolic;Molecular;Monitor;Mus;neural circuit;Neurons;Neurosecretory Systems;new therapeutic target;Night Sweating;Perimenopause;Photometry;Physiologic Thermoregulation;Postmenopause;Preoptic Areas;Quality of life;receptor expression;Regulation;Reporter;Reporter Genes;response;Response Elements;Role;sensor;Shivering;Signal Transduction;Skin;Structure of nucleus infundibularis hypothalami;Sweating;Tail;Temperature;Temperature Sense;Testing;Time;Tissues;tool;transcriptome sequencing;Transgenic Organisms;Variant;Vasodilation;vasomotor symptoms;Withdrawal;Woman

PROJECT_TITLE: Estrogenic modulation of neural circuits that control temperature

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative: Substantial evidence has documented inequities in the quality of care received by health disparity populations, undermining both the patients' and providers' ability to develop relationships characterized by high levels of commitment and trust, and ultimately leading to poorer outcomes. COVID-19 not only exposed these social inequities but also led to a rapid change of our health system – from in-person to remote visits. While some evidence suggests that care delivered via healthcare technologies could strengthen patient-provider relationships through improved access to the care team its technical and interpersonal drawbacks may reduce relationship commitment and trust; thus, identifying the multilevel impacts of healthcare technologies will provide much needed information for developing best practices to optimize the patient-provider relationship in health disparity populations when healthcare technologies are introduced.

PI_NAMEs: SCHOENTHALER, ANTOINETTE M (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Address;Adoption;Adult;Affect;Affective;Anxiety;anxiety states;Audiotape;automated text message;Behavior;behavior measurement;Behavioral;Black race;Blood Pressure;blood pressure control;Caring;Characteristics;Clinic;Clinical Management;Cognitive;Communication;Competence;contextual factors;COVID-19;Data;Data Sources;digital;disorder control;Electronic Health Record;Equipment and supply inventories;Equity;ethnic minority;Evaluation;experience;Faculty;Feedback;Funding;Health;health care quality;health disparity populations;health equity;Health Services Accessibility;Health system;Health Technology;Home;Household;human centered design;Hypertension;hypertension control;Improve Access;improved;Individual;Inequity;Infrastructure;Insurance;Interview;Investments;Latinx;Link;literacy;long-standing disparities;Measures;Medicaid;Medical;Medicare;medication compliance;medication nonadherence;Methods;Modality;National Institute on Minority Health and Health Disparities;Natural Language Processing;negative affect;Not Hispanic or Latino;Outcome;patient population;patient portal;Patient Self-Report;Patient-Focused Outcomes;Patients;Perception;Persons;Pharmacy facility;Physiological;primary care clinic;primary outcome;Privatization;programs;Provider;Quality of Care;racial minority;Records;remote patient monitoring;remote visit;Research;Research Design;Risk;safety net;secondary outcome;Secure;Site;social;Socioeconomic Status;Surveys;System;Techniques;Technology;telehealth;Telephone;theories;Therapeutic;tool;Trust;virtual health;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Do no digital harm? A multilevel evaluation of technology-facilitated team care on the patient-provider relationship in health disparity populations

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project narrative This proposal aims to identify the computational algorithms of two confidence-guided behaviors, time investment and choice strategy updating, and the neural processes underlying these. We will use a combination of electrophysiology, viral tracing, optogenetics in a quantitative confidence-reporting behavior in rats, interpreted with computational modeling and statistical analysis. We aim to test our central hypothesis that OFC generates an abstract representation of decision confidence that supports multiple confidence-guided behavioral processes.

PI_NAMEs: KEPECS, ADAM  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TITLE: Behavioral and neural algorithms for decision confidence

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


NIH_SPENDING_CATS: Biotechnology;Genetics;Obesity

ORG_CITY: AMES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Project Narrative  The project seeks to develop a comprehensive and tractable mitochondrial manipulation toolkit in a new yeast model that more closely resembles human mitochondrial biology, enhancing tractability of the findings in lower eukaryote testbeds to humans. The technological advancements would equip many research labs with the tools necessary to perform mitochondrial research, fill in critical gaps missing in the current understanding of mitochondrial DNA and its influence on function, and facilitate therapeutic treatments for mitochondrial dysfunction and pathogenicity.

PI_NAMEs: SHAO, ZENGYI  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Adipocytes;Adipose tissue;Aerobic;Area;Biochemical Pathway;Biology;Cells;Citric Acid Cycle;Clustered Regularly Interspaced Short Palindromic Repeats;cost;Development;Disease;drug development;engineering design;Epidemic;Equilibrium;Eukaryota;flexibility;fluidity;Functional disorder;Future;Gene Abnormality;Gene Dosage;Genetic;genetic manipulation;Genome;genome editing;Grant;Health;Human;human disease;Human Pathology;Inner mitochondrial membrane;insight;Iowa;Knowledge;Lipids;Mediating;metabolic engineering;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modeling;novel;Nuclear;Nucleic Acids;Obesity associated disease;obesity treatment;Pathogenicity;Phenotype;Physiology;reconstitution;Research;RNA;Role;Saccharomyces cerevisiae;Side;stem;Study models;Technology;Therapeutic;tool;tool development;Translating;Universities;Yarrowia lipolytica;Yeast Model System

PROJECT_TITLE: Establishing a Novel Instrumental Model for Elucidating Mitochondrial DNA-Associated Dysfunction and Pathogenicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Chronic Liver Disease and Cirrhosis;Dementia;Digestive Diseases;Liver Disease;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: CLAREMONT

ORG_NAME: KECK GRADUATE INST OF APPLIED LIFE SCIS

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is the sixth leading cause of death in the United States with approximately 5.8 million Americans living with AD. Many studies show a positive association between heavy alcohol consumption and AD development and progression. Our proposal explores how chronic alcohol consumption affects the liver and brain to induce and/or exacerbate AD.

PI_NAMEs: HAN, DERICK S (contact);SUMBRIA, RACHITA

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Abeta clearance;AD transgenic mice;Affect;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol research;Alcohol-Induced Disorders;Alcoholic Liver Diseases;Alcohols;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;American;Amyloid beta-Protein;Area;Biological Products;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier permeabilization;Brain;brain health;Cause of Death;Cerebral endothelium;Chimeric Proteins;Chronic;chronic alcohol ingestion;Data;Deposition;Development;Dichloromethylene Diphosphonate;Down-Regulation;Etanercept;Fc(alpha) receptor;feeding;Goals;Hepatic;Homeostasis;In Vitro;in vivo;Inflammation;insight;Knowledge;knowledge of results;Kupffer Cells;Lipoprotein Receptor;Liposomes;Liver;liver function;liver injury;Low Density Lipoprotein Receptor;Mediating;Metabolic;migration;Modeling;Mus;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;Neuronal Injury;neurovascular;new therapeutic target;novel;old mice;Organ;overexpression;Pathology;Peripheral;Plasma Proteins;problem drinker;receptor;receptor for advanced glycation endproducts;Research;Role;Source;Specialist;success;synergism;tau Proteins;Techniques;Testing;TNF gene;TNFRSF1A gene;United States;wasting;Work

PROJECT_TITLE: Modulation of the liver-brain axis by alcohol and its impact on Alzheimers disease pathology


ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Transcription of HIV and latency are fundamentally controlled by epigenetic regulations, which is essential for us to take efforts to control HIV reservoirs. This proposal will investigate how a novel and distinct epigenetic molecular signaling –protein crotonylation- directly regulates HIV transcription and latency and how a better understanding of crotonylation signaling can be applied to design specific HDCR inhibitors. Discovery of such a specific HDCR inhibitor may not only help us better understand the catalytic selection of HDCR over HDAC but also can be utilized to improve latency reversal for the cure of HIV in the future.

PI_NAMEs: JIANG, GUOCHUN  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acceleration;Acetylation;antiretroviral therapy;Benzamides;beta-Transducin Repeat-Containing Proteins;Binding;CD4 Positive T Lymphocytes;Cell model;Chemical Structure;Chromatin;chronic infection;Clinical Research;Complex;Data;Deacetylation;design;Enzymes;EP300 gene;Epigenetic Process;epigenetic regulation;Exposure to;Future;Genetic Transcription;Goals;HDAC3 gene;Health;Histone Deacetylase;Histone Deacetylase Inhibitor;histone methylation;Histones;HIV;HIV Infections;HIV-1;improved;in vitro Model;Infection;inhibitor;interest;knock-down;latent HIV reservoir;Lysine;Mediating;Methylation;Modernization;Modification;Molecular;MS-275;mutant;novel;overexpression;Patients;Persons;Play;Post-Translational Protein Processing;prevent;promoter;Proteins;Proteomics;Proviruses;Regulation;Role;Signal Transduction;Signaling Protein;transcription factor;Viral;Viral reservoir;Virus Diseases

PROJECT_TITLE: Novel Epigenetic Marks for HIV Latency Entry and Reversal

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Microbiome;Nutrition;Osteoporosis;Prevention

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Glucocorticoid induced osteoporosis (GIO) results in increased fracture risk and is the leading cause of secondary osteoporosis worldwide. There is a critical need for discovery of naturally occurring, novel therapeutics to prevent and/or treat GIO. This project seeks to address this need by investigating the mechanisms by which prunes can prevent GIO.

PI_NAMEs: CHARGO, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Acids;Address;Adherence;adherence rate;Aging;Amaze;Apoptosis;bone;Bone Density;bone health;bone turnover;Cells;Clinical Trials;combat;Complementary Health;cost;cost effective;Data;density;Diet;dietary;Disease;Dose;Dryness;fecal transplantation;feeding;Fellowship;Fiber;Fracture;fracture risk;Fruit;Gene Expression;Gene Expression Profiling;Glucocorticoids;gut health;gut microbiota;Health;Health Care Costs;Human;human microbiota;human model;improved;In Vitro;in vivo;in vivo Model;Incidence;innovation;Integrative Medicine;Intestines;Link;Literature;Mediating;metabolomics;microbial;microbiota;microbiota composition;Mission;Modeling;mouse model;Mus;National Center for Complementary and Integrative Health;new therapeutic target;Nonpharmacologic Therapy;novel therapeutic intervention;novel therapeutics;Osteoblasts;Osteogenesis;Osteoporosis;Osteoporosis prevention;Outcome;Outcome Measure;Pathogenesis;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Placebos;Play;Plum;pre-clinical;Pre-Clinical Model;prevent;Prevention;primary outcome;Probiotics;Production;response;Role;Safety;Science;Serum;side effect;stool sample;substantia spongiosa;targeted treatment;Testing;Training;transplant model;Tryptophan;Tryptophan Metabolism Pathway

PROJECT_TITLE: Critical Role of the Gut Microbiota in Prunes’ Prevention of Glucocorticoid Induced Osteoporosis


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Health Services;Substance Misuse

ORG_CITY: WALTHAM

ORG_DEPT: MISCELLANEOUS

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative Alcohol-related services research can lead to improved systems for prevention, treatment and recovery services, thereby enhancing quality and reducing the adverse consequences of alcohol use disorders. Training the next generation of alcohol services researchers continues to be crucial because of the continued magnitude of alcohol problems in the US, the complexity of delivery systems, and the rapid changes in the overall healthcare environment.

PI_NAMEs: HORGAN, CONSTANCE M. (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TITLE: Doctoral Training/Alcohol-Related Health Services Research


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Understanding relationships between eating behaviors, mental health, and cultural food values is critical to developing culturally-informed diabetes prevention intervention programs, especially among underserved urban American Indian/Alaska Native (AI/AN) communities. The proposed NRSA community-based participatory research will employ sequential exploratory mixed-methods to understand AI/AN cultural food values and eating behaviors, and to culturally adapt and evaluate an intuitive eating measure and finally to assess the relationship between intuitive and cultural eating behaviors to health outcome data (e.g., mental health, fruit/vegetable intake). Findings from this community-based participatory research will inform future diabetes prevention intervention development with urban AI/AN communities who represent the vast majority of AI/ANs in the US yet are rarely included in diabetes research and prevention intervention.

PI_NAMEs: MAUDRIE, TARA LAUREN (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Address;Adult;Affect;Age;Alaska Native;Alaska Native population;American Indian Population;American Indians;Awareness;Baltimore;Behavior;Biological;Blood;cardiovascular disorder risk;Cholesterol;Chronic Disease;Collaborations;Communities;community based participatory approach;community based participatory research;community clinic;community engagement;community partners;community research;Cues;Data;Dedications;Development;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;Diet;disorder risk;Doctor of Philosophy;doctoral student;Eating;Eating Behavior;Emotional;Environment;experience;Face;Factor Analysis;Fellowship;Food;food insecurity;fruits and vegetables;Funding;Future;Gestational Diabetes;glycemic control;Goals;Health;health data;health equity;health organization;Healthy Eating;High Prevalence;Hunger;improved;Individual;innovation;Intake;Intervention;intervention program;Intervention Studies;Interview;Intuition;Knowledge;Linear Regressions;Logistic Regressions;Low-Density Lipoproteins;Measurement;Measures;Mental disorders;Mental Health;Mentally Ill Persons;Mentorship;Methods;Mind;Mission;Modeling;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;National Research Service Awards;Native American community;Native Americans;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Outcome;Outcome Measure;Participant;Patient Self-Report;Perception;Personal Satisfaction;Physical activity;Physiological;pilot test;Population;prevent;Prevention;Prevention strategy;preventive intervention;primary outcome;Psyche structure;psychologic;Psychology;psychosocial;Public Health Schools;Quality of life;racial population;Research;Research Design;Research Methodology;Research Personnel;research study;Resources;Sampling;Satiation;Scholarship;skills;social;Social Environment;syndemic;therapy development;Training Support;trend;Triglycerides;United States;United States National Institutes of Health;urban Native American;urban underserved

PROJECT_TITLE: Urban American Indian/Alaska Native Cultural Eating Values and Behaviors: Community-based, mixed methods research to inform a holistic and culturally-informed diabetes prevention intervention program


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE The overarching goal of this project is to use the Jackson Heart Study— a state-of-the-art cohort study of African American adults— to investigate longitudinal associations between features of the neighborhood physical, social, and healthcare environment and cardiometabolic risk development and management over a 20-year period. Understanding these associations independently and synergistically is critical for the prevention and management of cardiovascular disease risk factors in African Americans and the reduction of racial health inequalities.

PI_NAMEs: BARBER, SHARRELLE M (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Acceleration;Adult;Affect;African American;African American population;Area;Barbering;Behavioral;Behavioral Research;Biological;Biomedical Research;Blood Pressure;blood pressure control;built environment;burden of chronic illness;cardiometabolic risk;cardiovascular disorder risk;Characteristics;Chronic Disease;cohort;Cohort Studies;contextual factors;Country;County;Data;Data Collection;Databases;Development;diabetes control;Diabetes Mellitus;diabetic;Disparity;Economics;Enrollment;Environment;Epidemiology;epidemiology study;Evidence based intervention;fasting glucose;Geography;Goals;health disparity;Health Food;health inequalities;Health Services Accessibility;Healthcare;Heterogeneity;high risk population;Hypertension;hypertension control;hypertensives;improved;Incidence;insight;Intervention;Investigation;Jackson Heart Study;Light;Link;Mediating;Methodology;metropolitan;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Persons;Physical environment;Policies;Population;population based;Population Density;Prevention;Primary Care;primary care services;Process;programs;psychosocial;Psychosocial Factor;Public Health Schools;Race;racial disparity;Recreation;Research Personnel;residential segregation;Risk Factors;Role;Safety;Shapes;social;social cohesion;Social Conditions;Social Environment;structural determinants;Subgroup;Techniques;therapy design;Time;Universities;urban area

PROJECT_TITLE: Cardiometabolic Risk Development and Management in Changing Neighborhoods: the Jackson Heart Study

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Congenital Structural Anomalies;Human Fetal Tissue;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Human cerebellar malformations are clinically important birth defects that cause substantial morbidity and mortality and are poorly understood. Cerebellar involvement is also central to common neurodevelopmental disorders, including Autism and Intellectual Disability, yet very little is known about human cerebellar development. These experiments are designed to fill a considerable knowledge gap regarding the cellular and molecular programs that drive normal human cerebellar development and the pathogenesis of human cerebellar malformations.

PI_NAMEs: MILLEN, KATHLEEN JOYCE (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Affect;Affective;Anatomy;Atlases;Attention deficit hyperactivity disorder;autism spectrum disorder;Automobile Driving;Behavioral;Biological Models;Biology;Birth;Blood Vessels;brain malformation;Cell Cycle;cell type;Cells;Cellular Assay;Cerebellar Diseases;Cerebellar malformation;Cerebellar vermis structure;Cerebellum;Chick;Clinical;Cognition;Cognitive;Conceptions;Congenital Abnormality;Counseling;Dandy-Walker Syndrome;Data;Data Set;data standards;Development;developmental disease;Diagnosis;Diagnostic;Experimental Designs;experimental study;Family;Fetal Development;Gene Expression;Genes;Genetic Complementation Test;Goals;Head;Heterogeneity;Histologic;Human;human fetal cerebellar tissue;human model;humanized mouse;Image;imaging study;Immunohistochemistry;improved;In Situ;In Situ Hybridization;In Vitro;in vivo Model;insight;Intellectual functioning disability;Knowledge;Lateral;Light;Linguistics;Lip structure;Macaca mulatta;Medial;Medulloblastoma;Meninges;Mesenchyme;Methods;Microscopy;model organism;Modeling;Molecular;Morbidity - disease rate;Morphology;mortality;Motor;motor control;mouse model;Mus;Neurodevelopmental Disorder;neurogenesis;Neurons;nonhuman primate;novel;Nuclear;Outcome;Output;Pathogenesis;Pathologic;Play;Posterior Fossa;Pregnancy;prenatal;Process;progenitor;programs;Proliferating;Property;Regulation;Reporting;Research;RNA Sequences;Role;Sampling;Schizophrenia;sensory integration;Signal Transduction;single cell analysis;single-cell RNA sequencing;social deficits;Source;Specific qualifier value;stem cells;transcriptomics;vascular bed;Ventricular

PROJECT_TITLE: Pathological Mechanisms of Human Cerebellar Malformations

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ORG_CITY: STONY BROOK

ORG_DEPT: PSYCHIATRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: NARRATIVE Radiolabeled peptides are emerging as a very valuable class of compounds for both molecular imaging tools and therapeutics. The goal of this proposal is the development of a new technology to radiolabel peptides that yields high purity, high molar activity tracers in biologically compatible formulation without need for costly reconstitution and purification steps, and can potentially be fully integrated into existing automated peptide synthesis. Successful completion of this project will provide a new tool for molecular imaging as well as an opportunity to broaden the use of positron emission in the fundamental understanding of molecular interactions in biological systems

PI_NAMEs: PARKER, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Amino Acids;anti-microbial peptide;Automation;Bacteriophages;Binding;Biological Assay;biological systems;Biology;Cells;Chemicals;Chemistry;Clinical;clinical translation;Collection;cost;density;Development;Diagnosis;Diagnostic;Discitis;Dose;drug development;drug discovery;Ensure;Escherichia coli;Evaluation;expectation;Fluorine;Formulation;Goals;Human;Image;imaging agent;Imaging Device;improved;in vitro Assay;Infection;infection management;Inflammation;information gathering;Injections;Label;Libraries;Medicine;Methods;Modeling;Molecular;molecular imaging;mouse model;Mus;Myositis;new technology;novel;novel strategies;Oncology;Organism;Osteomyelitis;pathogen;pathogenic bacteria;Peptide Synthesis;Peptides;Phage Display;Pharmacology;Play;Positron;Positron-Emission Tomography;Process;Proxy;radiochemical;Radiochemistry;Radiolabeled;radiotracer;Reaction;reconstitution;Research;Role;Sampling;screening;septic;Series;Side;small molecule;Soft Tissue Infections;Specificity;spine bone structure;Staphylococcus aureus;Staphylococcus aureus infection;Sterility;Structure;Techniques;Technology;Testing;Therapeutic;Time;tool;Tracer;Translating;Variant;Wild Type Mouse

PROJECT_TITLE: Catch and Release Radiolabeled Peptides: a new technology for radiotracer development

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]