NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Accounting;Animals;Antibodies;Biometry;Blinded;Budgets;Charge;Clinical;Collaborations;Communication;Data;data acquisition;Data Analyses;data integration;data management;Data Reporting;data sharing;Databases;Decision Making;Early identification;Ensure;Equity;Expenditure;experience;Experimental Designs;Financial Activity;Fostering;Goals;Grant;Human;human data;Immunology;In Situ;Institution;Lead;Leadership;meetings;member;Methodology;Monitor;Names;Online Systems;Program Evaluation;Program Research Project Grants;programs;Regulation;Reporting;Reproducibility;Research;Research Personnel;Resource Allocation;Resources;Scientific Evaluation;Secure;Strategic Planning;success;Supervision;symposium;System;United States National Institutes of Health;Universities;Viral Physiology;virology

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The goal of this study is to reduce the burden of cancer for the minority population in our catchment area. We will contribute in the scientific design of cancer clinical trials at the national level and locally will use outreach to educate our population about clinical research specifically in cancer control, prevention, care delivery, and novel therapies to improve the health of the community. By facilitating the enrollment and participation of minority and underserved cancer patients into clinical trials, we will achieve our ultimate goal of improving survival and quality of life of all individuals.

PI_NAMEs: AMENGUAL, JENNIFER E.;KACHNIC, LISA A. (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Advisory Committees;Age;base;biobank;Cancer Burden;cancer care;Cancer Center;cancer clinical trial;Cancer Control;Cancer Patient;cancer prevention;cancer therapy;care delivery;Catchment Area;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communities;Community Clinical Oncology Program;Community Health;Continuity of Patient Care;design;Enrollment;Ethnic Origin;Gender;Goals;health care disparity;Health Personnel;Herbert Irving Comprehensive Cancer Center;improved;Individual;Infrastructure;Institutional Review Boards;Lead;Leadership;Medical center;Minority;Minority Groups;Minority Participation;novel therapeutics;outreach;patient population;Patients;Phase;Population;Prevention;programs;Quality of life;Race;Research;Role;screening;Sex Orientation;Site;Socioeconomic Status;Therapeutic Trials;Tissues;underserved community;Universities

PROJECT_TITLE: Columbia University Minority/Underserved Site NCI Community Oncology Research Program


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Viewing the same scene or object can drive different responses in visual cortex depending on whether the observer is stationary or moving, engaged or passive. Enabling this context-dependent processing is thought to be a key function of the neuromodulator acetylcholine, and deficits of acetylcholine are associated with disorders ranging from Alzheimer's Disease to schizophrenia; however, the mechanisms through which acetylcholine modulates the cortex are incompletely understood, hampering the development of treatments. This proposal dissects the action of acetylcholine on specific cell types in the visual cortex, clarifying how this neuromodulator impacts components of the cortical circuity to drive context-specific processing.

PI_NAMEs: CAMMARATA, CELINE  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Acetylcholine;Acute;Alzheimer's Disease;Animals;area striata;Arousal;Behavior;Behavioral;Calcium;cell type;Cells;cholinergic;Cognitive;Conflict (Psychology);Coupled;D Cells;Data;Dependence;Detection;Diameter;Disease;Disinhibition;experimental study;GABA Receptor;gamma-Aminobutyric Acid;Goals;Image;Interneurons;Locomotion;Measures;Methodology;Modeling;Mus;Muscarinic Acetylcholine Receptor;Muscarinics;neural;Neuromodulator;neuroregulation;Neurotransmitters;Output;Pathway interactions;Pharmaceutical Preparations;Population;prevent;Process;Pupil;Pyramidal Cells;receptor;recruit;response;Role;Schizophrenia;Shapes;Signal Transduction;Somatostatin;Specificity;Stimulus;Techniques;Testing;therapy development;two-photon;Vasoactive Intestinal Peptide;Visual;Visual Cortex;visual discrimination;visual information;visual processing;visual stimulus

PROJECT_TITLE: Dissecting cholinergic modulation of interneurons underlying state-dependent processing in mouse visual cortex


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: POLLARA, JUSTIN JOSEPH (contact)

PROJECT_TERMS: Active Immunization;Alleles;Animals;Antibodies;Antibody Diversity;Antibody Response;Antigen-Antibody Complex;Antigens;Bar Codes;Base Sequence;Biophysics;Cell Line;Cell Surface Proteins;Cells;Cellular biology;clinical trial participant;Clinical Trials;Collection;Computing Methodologies;Data;Data Analyses;Data Reporting;Data Set;Development;Disease Progression;disorder risk;Effector Cell;Evaluation;experience;experimental study;Fc domain;Fc Immunoglobulins;Fc Receptor;Future;Generations;Genes;Genetic Polymorphism;Genetic Variation;Genotype;Goals;Haplotypes;HIV;HIV-1;HIV-1 vaccine;Human;Immune;Immune response;Immunoglobulin Allotypes;Immunology;immunoprophylaxis;improved;In Situ;In Vitro;in vivo;Individual;Infection;infection risk;innovation;Knowledge;Macaca mulatta;Mediating;Methods;Modeling;Monitor;Monoclonal Antibodies;neutralizing antibody;next generation sequencing;novel;Outcome;outcome prediction;Outcome Study;Passive Immunization;Phenotype;Population;Production;programs;prophylactic;prospective;Protein Isoforms;Reagent;receptor;Receptor Gene;Recombinants;Regulation;Reporting;Research Personnel;Research Project Grants;Research Support;Resources;response;Rhesus;Sampling;Sequence Analysis;Serology;Services;Signal Transduction;simian human immunodeficiency virus;Single Nucleotide Polymorphism;Structure;Surveys;Testing;Therapeutic;tool;transcriptome;transcriptome sequencing;Translations;vaccine candidate;vaccine strategy;Validation;Viral;Viral Antibodies;Viral Physiology;Viral Proteins;Viremia;Virus;Work

PROJECT_TITLE: Physical Resources Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care;Psychosis;Schizophrenia;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The knowledge gathered from this project is of significant public health relevance as it has potential to facilitate more rapid and timely detection and treatment of first episode psychosis (FEP) by evaluating the utility of systematic screening and communication strategies for psychotic symptoms. Current methods for identifying and treating FEP in the US are associated with long average duration of untreated psychosis (DUP), typically over one year, with longer DUP associated with greater symptomatic and psychosocial impairment, and reduced responsiveness to established treatments. Reducing the DUP could alleviate patients’ and their families’ suffering, reduce psychiatric disability, and decrease economic losses to the society, including both treatment costs and loss of productivity associated with disability.

PI_NAMEs: LANDA, YULIA  (contact)

PROGRAM_OFFICER_NAME: DAVIS, BESHAUN JAMAAL

PROJECT_TERMS: Administrator;Age;aged;attenuated psychosis syndrome;Attitude;Caring;Client satisfaction;Clinic;clinical high risk for psychosis;Communication;Communication Methods;Communities;community clinic;Consolidated Framework for Implementation Research;Consultations;Coordinated Specialty Care;Data;design;Detection;disability;duration of untreated psychosis;Early Diagnosis;Early identification;Early Intervention;Economics;effectiveness testing;Equipment and supply inventories;Family;first episode psychosis;functional restoration;Future;Health system;help-seeking behavior;Hybrids;Impairment;implementation barriers;implementation determinants;implementation facilitators;implementation strategy;implementation study;improved;Individual;innovation;Intervention;Interview;Knowledge;Measures;Mediating;medical specialties;Mental Health;Mental Health Services;Methods;Modeling;National Institute of Mental Health;Netherlands;New York;Outcome;Patients;Population;practice setting;Procedures;productivity loss;programs;psychiatric disability;Psychoses;psychosis risk;psychosocial;psychotic symptoms;public health relevance;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;Recovery of Function;recruit;reduce symptoms;Relapse;Research;routine practice;routine screening;Schizophrenia;screening;service engagement;Services;social stigma;Societies;Structure;Symptoms;Taxonomy;Time;Training;Treatment Cost;Treatment outcome;trial design;Youth

PROJECT_TITLE: Early Stage Identification and Engagement to Reduce the Duration of Untreated Psychosis: Evaluating the Impact of Screening and Systematic Communication

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Adverse infant and maternal outcomes during the perinatal period continue to have deleterious effects throughout the life course. Neighborhood deprivation and discrimination contribute to these adverse outcomes and their related disparities, but the role of social support as a potential buffer against these effects is poorly understood. Our findings could assist in better identifying vulnerable pregnant women most likely to benefit from additional social support resources, without sacrificing the long-term goal of creating structural and societal changes that reduce neighborhood deprivation and discrimination.

PI_NAMEs: DIXON, MEREDITH A. (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;adverse birth outcomes;Adverse effects;adverse outcome;Affect;Area;Birth;Buffers;Characteristics;Child;Child Health;clinical care;cohort;Communities;Community Health;Data;Data Set;deprivation;Development;Dimensions;Discrimination;Disparity;Environment;Epidemiologic Methods;Epidemiology;Fellowship;First Pregnancy Trimester;Foundations;Goals;Health;health disparity;High Risk Woman;High-Risk Pregnancy;improved;indexing;Infant;Infant Mortality;infant outcome;Insurance;Intervention;Knowledge;large datasets;Life Cycle Stages;Light;Link;Loneliness;Low Birth Weight Infant;maternal morbidity;Maternal Mortality;maternal outcome;maternal stress;Measures;Medical;Mentors;Monitor;Morbidity - disease rate;Mothers;National Institute of Child Health and Human Development;Neighborhoods;Nulliparity;Outcome;Outcome Study;pandemic disease;perceived discrimination;Perinatal;perinatal health;perinatal outcomes;perinatal period;Postdoctoral Fellow;postnatal;Postpartum Depression;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;prenatal;Prenatal care;Preparation;programs;Psyche structure;psychosocial;racial difference;racial population;Randomized, Controlled Trials;Research;Resources;Risk;Risk Factors;Role;screening;Site;Small for Gestational Age Infant;Social Environment;Social outcome;Social support;Specimen;Stress;Subgroup;Substance abuse problem;Suicide;Support Groups;Surveys;Testing;Training;Woman;Women's Health;women's outcomes;women's treatment

PROJECT_TITLE: The Role of Social Support as a Buffer Against Adverse Perinatal Outcomes Among Women Experiencing Discrimination and Neighborhood Deprivation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Autism spectrum disorder is one of the most perplexing neurodevelopmental conditions facing modern medicine today, with lifelong implication for affected families and society at large. This project will use an innovative smartphone app to collect information about infant social development during the first two years of life and compare this to genetic prediction markers, with the aim of better understanding how genetic factors and social experience contribute to the overall likelihood of autism. This will help to overcome a critical barrier to progress in the field by identifying potentially modifiable early risk factors amenable to intervention.

PI_NAMEs: STRATHEARN, LANE  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: 2 year old;accelerated epigenetic aging;Address;Affect;Age;age acceleration;Algorithms;Anxiety;anxiety symptoms;autism spectrum disorder;autism symptoms;Behavior;Behavioral;Biological;biological age;Birth;Blood;Cellular Phone;Child;Chronology;Clinical assessments;cognitive development;Communication;Data;Day Care;depressive symptoms;Development;Developmental Delay Disorders;Devices;Diagnosis;Diagnostic;digital;disability;DNA Methylation;Dryness;Early Intervention;Early treatment;Ecological momentary assessment;Environment;epigenetic aging;epigenetic clock;epigenetic marker;Epigenetic Process;Etiology;experience;Family;Genes;Genetic;Genetic Polymorphism;genetic predictors;Genetic Predisposition to Disease;genomic locus;Goals;Home;Individual;Infant;innovation;Intervention;Knowledge;Language;Life;Link;Measures;Mediating;Mental Depression;Modern Medicine;Modification;Neurodevelopmental Disability;Newborn Infant;novel;offspring;Outcome;Oxytocin;Oxytocin Receptor;Parents;Pathway interactions;Patient Self-Report;Pattern;Perinatal;Persons;Phenotype;Play;polygenic risk score;postnatal;predictive marker;Pregnancy Trimesters;Pregnant Women;prenatal stress;Prevalence;Process;prospective;Questionnaires;Race;receptor;Receptor Gene;recruit;repetitive behavior;Reporting;Research;Risk;Risk Factors;Role;Sampling;sex;skills;smartphone application;social;social communication;Social Development;Social Interaction;Societies;Socioeconomic Status;Spottings;Standardization;Stress;Testing;Third Pregnancy Trimester;Time;Video Recording

PROJECT_TITLE: Perinatal Experience and Epigenetic Change in Autism: Discovering Modifiable Pathways for Intervention

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: TOMARAS, GEORGIA DORIS (contact)

PROJECT_TERMS: Animal Model;Antibodies;Antibody Response;Antigen-Antibody Complex;Antigens;Architecture;Binding;Biochemical;Biological;Biological Models;Biology;Biophysics;Blood;cell type;Cells;Characteristics;Clinic;Complex;Computing Methodologies;Data;Data Analyses;data integration;Dissection;diverse data;Effector Cell;env Gene Products;Epitopes;experimental study;Extracellular Domain;Fc Receptor;Fc(alpha) receptor;Gene Expression Profiling;Genetic Transcription;glycosylation;Goals;High Pressure Liquid Chromatography;HIV Antibodies;HIV-1;Human;human model;Immune;Immunoglobulin A;Immunoglobulin G;Immunoglobulins;Immunologic Receptors;immunoprophylaxis;In Situ;In Vitro;in vivo;Infection;Inflammation;Infusion procedures;insight;interest;Knowledge;Lead;Macaca mulatta;Maps;Mediating;Methods;Modeling;Molecular;Monoclonal Antibodies;mouse model;neonatal Fc receptor;nonhuman primate;Outcome;Peptides;Phenotype;Play;polyclonal antibody;Polymeric Immunoglobulin Receptors;Polysaccharides;Population;Post-Translational Protein Processing;programs;protective efficacy;receptor;receptor binding;Recombinants;Regimen;Resolution;response;Role;Sampling;Specificity;Standardization;Structure;Therapeutic Studies;Tissues;Translating;Vaccine Design;vaccine trial;Vaccines;Variant;Viral;Viral Antibodies;Viral Load result;Viral Physiology

PROJECT_TITLE: Structure-Function Analytics Core


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Cancer;Genetics

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE As shown by BRCA mutations, DNA damage causes cancer, is used to treat cancer, and acts in side effects to cancer treatment. Yet, DNA damage effects depend upon poorly understood BRCA DNA repair complexes (DRC) that are also a target for advanced treatments. To advance cancer medicine, our MANTIS-DRC project will provide foundational structural and mechanistic knowledge on BRCA repair complexes and their connections to cancer biology and therapeutic resistance.

PI_NAMEs: TAINER, JOHN A. (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Abscopal effect;Advanced Malignant Neoplasm;Bayesian Method;Biological;BRCA mutations;BRCA1 gene;Cancer Biology;Cancer Etiology;cancer therapy;Cell Physiology;Cell Survival;Cells;Clinical;Data;data integration;Data Set;Databases;Defect;design;Dissection;Distant;DNA;DNA Damage;DNA Repair;DNA Repair Pathway;DNA Structure;Embryo;experience;Funding;Future;Genomic Instability;human DNA;Image;Immune response;inhibitor;Ionizing radiation;Knowledge;large datasets;Link;Malignant Neoplasms;Maps;Measurement;Measures;Medicine;Molecular Conformation;Mutation;nanoscale;neoplastic cell;Outcome;Pathway interactions;Patients;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;programs;Proteins;Radiation;Repair Complex;Resistance;Resistance development;Resolution;response;Roentgen Rays;Seminal;side effect;Site;Spatial Distribution;Structure;Technology;Testing;therapy resistant;tool;tumor;Work

PROJECT_TITLE: Mesocale And Nanoscale Technologies Integrated by Structures for DNA Repair Complexes (MANTIS-DRC)


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Natural Products

ORG_CITY: LOS ANGELES

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE The natural products and pharmacologically relevant compounds stemming from this project have significant biomedical ramifications, specifically in cancer, diabetes, immunology, inflammation, anesthesia, anti-HSV, anti- adenoviral, depression, and Alzheimer’s and Parkinson’s diseases.

PI_NAMEs: KWON, OHYUN  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Phosphine-Catalyzed Annulations and their Applications

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Brain Disorders;Cerebrovascular;Neurosciences;Rehabilitation;Sleep Research;Stroke;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Stroke is the leading cause of disability in the United States, leaving a substantial number of survivors with permanent weakness. Neuromodulation of sensorimotor areas using physiologically targeted low- frequency stimulation is an innovative new direction to facilitate recovery of motor function. Our proposal seeks to optimize stimulation parameters to selectively target nodes in the motornetwork.

PI_NAMEs: GANGULY, KARUNESH  (contact);MORRISON, JOHN H

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: Affect;Area;Basal Ganglia;Behavior;Brain;Cells;Cephalic;Complex;Computer Analysis;Consensus;Data;Deep Brain Stimulation;design;dimension reduction;disability;Disease;Dorsal;Electric Stimulation;Electrodes;Frequencies;Goals;grasp;Impairment;improved;innovation;Joints;Link;Measures;Medicine;Methods;Modeling;Motor;motor behavior;Motor Cortex;Motor disability;motor function recovery;motor recovery;Motor Skills;Movement;Nature;neural;neural model;neural patterning;Neurons;neuropsychiatric disorder;neuroregulation;Neurosciences;non rapid eye movement;nonhuman primate;noninvasive brain stimulation;orientation selectivity;Parkinson Disease;Performance;Physiological;Play;Population Dynamics;post stroke;Preparation;prevent;Rattus;Recovery;Recovery of Function;response;Role;Sensory;sensory feedback;sensory integration;simulation;Sleep;Somatosensory Cortex;Stroke;stroke recovery;stroke trials;Survivors;Synaptic Transmission;Target Populations;Techniques;Testing;Therapeutic;Time;Uncertainty;United States;Work

PROJECT_TITLE: Optimizing oscillatory epidural electrical stimulation to selectively increase task-related population dynamics in motor areas


NIH_SPENDING_CATS: Biotechnology;Clinical Research;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: AIDS prevention;Animal Model;Antibodies;Antibody Binding Sites;Antibody Response;Antibody titer measurement;antibody-dependent cell cytotoxicity;Antibody-mediated protection;Biophysics;CD4 Positive T Lymphocytes;cell killing;Cell Physiology;Cells;comparative;Complement;confocal imaging;cross reactivity;Data;Databases;Differentiation Antigens;Effector Cell;efficacy testing;Epitopes;Equation;Exhibits;experimental study;Fc Receptor;Flow Cytometry;Goals;granulocyte;HIV;HIV Infections;HIV vaccine;Human;humanized mouse;Humoral Immunities;imaging modality;Immune;immune function;Immune system;Immunity;Immunodeficient Mouse;Immunoprevention;In Situ;In Vitro;in vivo;Infection;Knowledge;Link;Macaca mulatta;Measures;Mediating;Methods;Modeling;monocyte;Mouse Strains;Natural Killer Cells;Nature;neutralizing antibody;nonhuman primate;novel;novel strategies;Outcome;Pattern;Phagocytosis;preservation;prevent;Primary Infection;programs;protective effect;protective efficacy;rational design;reactivation from latency;reconstitution;recruit;response;simian human immunodeficiency virus;SIV;Surface;System;Testing;Therapeutic;Vaccination;Viral;Viral Physiology;Virus

PROJECT_TITLE: Mechanisms of Antibody Fc Mediated Protection


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE The Transplant Research and Education Center (TREC) at Houston Methodist Research Institute (HMRI) and J.C. Walter Jr. Transplant Center Houston Methodist Hospital (HMH) and Kaiser Permanente Southern California (KPSC) will partner to improve CKD care and transplant rates for patients in the KPSC health system through system changes, inclusion of a peer mentoring program, and dissemination of an innovative technology-supported (mHealth) application to engage patients, family members, and potential living donors in pursuing transplant, including learning how to find living donors. The investigators will conduct a stepped- wedge cluster randomized controlled trial of the multilevel intervention in 12 KPSC medical centers and examine its effects on referral for transplant (primary outcome) and secondary outcomes including engagement in transplant education, level of patient knowledge, clinician and health system adherence to best practice recommendations, transplant wait-listing, and increased LDKT rates. After examining factors that moderate the intervention’s effectiveness across settings and underserved subgroups, they will develop implementation resources to facilitate intervention spread within commercial, academic, and safety net healthcare systems across the U.S.

PI_NAMEs: MITTMAN, BRIAN S;WATERMAN, AMY DOGGETTE (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: Multilevel Intervention Strategies to Transform Kidney Care and Improve Pursuit of Transplant in an Integrated Healthcare Delivery System

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Clinical Research;Lung

PHR: Project Narrative During chronic allergic airway inflammation, rare chemosensory cells called tuft cells produce prostaglandin E2 (PGE2), which I hypothesize modifies mucus movement and airway inflammation, contributing to diseases such as asthma and nasal polyps. My proposal will use mouse modeling and cell culture to understand how tuft cell-derived PGE2 orchestrates immune and epithelial functions in the airway during allergic inflammation, and then investigate whether the same processes contribute to asthma in humans. These studies will advance fundamental knowledge of airway biology and may identify new therapeutic targets to treat millions of patients suffering with chronic allergic airway diseases.

PI_NAMEs: KOTAS, MAYA  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Address;Adopted;Air;Airway Disease;airway epithelium;airway hyperresponsiveness;airway inflammation;airway surface liquid;Allergic;allergic airway disease;allergic airway inflammation;Allergic inflammation;Animal Model;anti-microbial peptide;Antiinflammatory Effect;Apical;Asthma;asthmatic;behavior influence;Biology;Bronchi;Cell Culture Techniques;Cell secretion;Cells;cellular targeting;Chronic;chronic rhinosinusitis;Communities;comparative;Curiosities;Cystic Fibrosis;cytokine;Data;design;Dinoprostone;Disease;Edema;Effectiveness;Environment;Epithelial Cells;Epithelium;experimental study;Fluids and Secretions;Functional disorder;Future;Gene Expression Profile;Genetic Transcription;Goals;Grant;Growth;Homeostasis;Human;human subject;human tissue;Immune;immune cell infiltrate;immune function;Immune response;Immune system;immunoregulation;improved;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;Interleukin-13;Intestines;Knowledge;Liquid substance;Lung;Lymphoid Cell;Mediator;meetings;Membrane;Mentors;Molecular Target;Morbidity - disease rate;mortality;mouse model;Movement;Mucociliary Clearance;Mucous body substance;mucus hypersecretion;Mus;Nasal Polyps;Nasopharynx;new therapeutic target;novel therapeutics;Organoids;Output;Pathology;Patients;Phenotype;Physicians;Physiological;Process;Production;Prostaglandin Production;pulmonary function;Reaction;receptor;Regulation;Reporting;Research;respiratory challenge;respiratory colonization;response;Role;role model;Scientist;Secretory Cell;Sensory;single cell sequencing;Sinus;skills;Small Intestines;Specialized Epithelial Cell;Surface;Symptoms;Techniques;Testing;therapeutic target;Tissues;tool;Trachea;Training;translational study;WFDC2 gene

PROJECT_TITLE: Defining the role of tuft cells in allergic airway disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hematology;Prevention;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Social determinants of health increase the morbidity of atrial fibrillation. This study will examine how individual- and neighborhood-level social factors relate to access to anticoagulation – an essential medication for individuals with atrial fibrillation – and its adherence. The project will support robust mentoring in patient- oriented, health services research for junior clinical investigators focusing on social determinants and cardiovascular disease.

PI_NAMEs: MAGNANI, JARED W. (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Acceleration;Achievement;Address;Adherence;administrative database;Affect;Anticoagulants;Anticoagulation;Area;Atrial Fibrillation;Award;Cardiology;Cardiovascular Diseases;career development;Censuses;Cessation of life;Clinical;Clinical Investigator;Clinical Sciences;clinical trial recruitment;Clinical Trials Design;Communities;Complement;Data;Databases;Dementia;deprivation;Diagnosis;Disparity;disparity reduction;doctoral student;Education;Electronic Health Record;Ethnic Origin;Evaluation;Fellowship;Fostering;Funding;Geographic Information Systems;Guidelines;Health;health equity;Health Services;Health Services Research;Healthcare Systems;Heart failure;Home;Household;improved;Income;Individual;Individual Adjustment;Infrastructure;innovation;Inpatients;Internal Medicine;Intervention;Investigation;Ischemic Stroke;K-Series Research Career Programs;Literature;Measures;Mediation;Medical Care Costs;Medical center;medical schools;Medicine;Mentors;Mentorship;metropolitan;Morbidity - disease rate;multidisciplinary;Myocardial Infarction;National Heart, Lung, and Blood Institute;neighborhood association;Neighborhoods;novel;Occupations;Oral;Outcome;Outpatients;Ownership;Participant;Pathway interactions;patient oriented;patient oriented research;Patients;Pennsylvania;Pharmaceutical Preparations;Postdoctoral Fellow;pre-doctoral;prevent;programs;prospective;Public Health;Public Health Schools;Race;randomized, clinical trials;Recruitment Activity;Reporting;Research;residence;Residencies;Resources;Risk;Role;Rural;rurality;secondary analysis;segregation;social;social determinants;social disparities;social factors;social health determinants;Stroke prevention;success;thromboembolic stroke;Training;Training Programs;Translational Research;treatment and outcome;Universities;Visit;Vocation;Warfarin

PROJECT_TITLE: Mentoring in patient-oriented research in social determinants and atrial fibrillation

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Hematology;Lung;Organ Transplantation;Rare Diseases;Transplantation

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Primary graft dysfunction (PGD) is severe lung injury that occurs after lung transplantation and predicts poor clinical outcomes. We propose that elevated levels of cell-free hemoglobin (CFH) in the bloodstream and in the airspace cause PGD through injury to the lung endothelial and epithelial barrier, and that CFH accumulation and oxidation is promoted by common clinical practices used to care for lung transplant patients. In this application, we will establish a three-center study to determine how CFH causes PGD and how clinical management alters accumulation and oxidation of CFH, laying the groundwork for clinical trials targeting CFH to reduce risk of PGD.

PI_NAMEs: SHAVER, CIARA M (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute Lung Injury;Affect;Alveolar;Alveolar Cell;Automobile Driving;Biological Markers;Blood capillaries;Blood Circulation;Cardiopulmonary Bypass;Caring;Case/Control Studies;Cells;Characteristics;Circulation;Clinical;clinical development;Clinical Management;clinical practice;Clinical Trials;clinically relevant;Cohort Studies;Critical Illness;Data;Development;Endothelium;Epithelium;Extracorporeal Membrane Oxygenation;Foundations;Functional disorder;Geography;graft dysfunction;Hemoglobin;Hemoglobin concentration result;Hemolysis;Human;Hyperoxia;Impairment;Injury;insight;Intervention;Lipid Peroxidation;Liquid substance;Lung;lung allograft;lung injury;Lung Transplantation;Measures;Mechanical ventilation;Mechanics;Mediating;Mediator;Microvascular Permeability;Modeling;modifiable risk;Molecular;novel;Outcome;oxidation;oxidative damage;Patients;Pattern;Perfusion;Perioperative;Permeability;Pilot Projects;Plasma;Plasma Cells;Practice Pattern Variations;pressure;Publishing;Pulmonary Edema;Reperfusion Therapy;Risk;Risk Factors;Risk Reduction;Role;Severities;Site;Testing;Therapeutic Clinical Trial;translational study;Translations;transplant centers;Transplant Recipients

PROJECT_TITLE: Peri-operative factors that drive cell-free hemoglobin-mediated primary graft dysfunction


ADMINISTERING_IC: AR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE - Overall Understanding inflammatory arthritis and related diseases requires access to high-quality biosamples and to increasingly sophisticated experimental and analytical tools. The Joint Biology Consortium represents the collective effort of a network of more than 70 researchers from 18 centers to overcome logistical challenges together in order to build a powerful engine of translational research in rheumatology and orthopedics.

PI_NAMEs: NIGROVIC, PETER A (contact);SPARKS, JEFFREY ANDREW

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Acceleration;Adult;Ally;analytical tool;Antigens;Archives;Arthritis;ATAC-seq;Award;biobank;Bioinformatics;Biology;Biometry;Boston;career;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Child;Childhood;cohort;Communities;Consent;Consultations;Country;CRISPR screen;Custom;Cytometry;Data;Dedications;design;Disease;diversity and inclusion;Education;Electronic Health Record;Environment;Feasibility Studies;Fostering;Genotype;Grant;Health;Heart;Hospitals;Human;Individual;Inflammatory Arthritis;Infrastructure;innovation;interest;Investments;Joints;Leadership;life span;Link;Medicine;meetings;member;Mentors;Methodology;Methods;Modeling;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;next generation sequencing;novel strategies;operation;Orthopedics;Patients;Pediatric Hospitals;Phage ImmunoPrecipitation Sequencing;Phenotype;Pilot Projects;Positioning Attribute;professor;Program Evaluation;programs;prospective;Proteins;Publications;recruit;Research;Research Personnel;Resources;Review Committee;Rheumatology;sample collection;Sampling;Scanning;service delivery;Services;single-cell RNA sequencing;Source;statistical service;success;synergism;System;Systemic Lupus Erythematosus;Techniques;Technology;Tissues;tool;transcriptomics;translational barrier;Translational Research;translational scientist;United States;Update;Visit;web portal;Woman;Work;Workforce Development

PROJECT_TITLE: Joint Biology Consortium Resource-based Center


NIH_SPENDING_CATS: Arthritis

PI_NAMEs: NIGROVIC, PETER A (contact)

PROJECT_TITLE: Administrative Core


PI_NAMEs: FERRARI, GUIDO  (contact)

PROJECT_TERMS: Address;Antibodies;Antibody Response;Antibody Specificity;Autologous;Binding;Biophysics;Cells;Clinical Research;Clinical Trials;Collaborations;cytokine;Data;defined contribution;design;Effector Cell;Epitopes;Fc Receptor;Foundations;Genetic;Genetic Complementation Test;genetic variant;Genetic Variation;Genotype;Goals;Heterogeneity;HIV-1;HIV-1 vaccine;Human;IgG Receptors;IgG1;IgG3;Immune response;Immunoglobulin A;Immunoglobulin Allotypes;Immunoglobulin G;immunoprophylaxis;improved;In Situ;in vivo;Incubated;Individual;Infection;infection risk;Inflammatory;Knowledge;Link;Lymphoid Tissue;Macaca mulatta;Mediating;Membrane;Modeling;Monoclonal Antibodies;monocyte;Mucous Membrane;Natural Killer Cells;Nature;neutralizing antibody;neutralizing monoclonal antibodies;NK Cell Activation;nonhuman primate;novel vaccines;Phagocytosis;Phenotype;Plasma;polyclonal antibody;preclinical study;Preparation;Prevention;Prevention strategy;programs;Property;recruit;Reporting;Research Personnel;response;Serum;Specificity;synergism;Testing;Therapeutic;Tissues;transcriptomics;Translating;translational impact;vaccine candidate;Vaccine Design;vaccine strategy;vaccine trial;vaccine-induced antibodies;Vaccines;Viral;Viral Physiology;Virion;Virus Replication;Work

PROJECT_TITLE: Linking Antibody Cooperativity and Effector Cell Engagement


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Immunotherapy;Infectious Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Nasopharyngeal Carcinoma (NPC) is a common form of head and neck cancer that is driven by Epstein Barr Virus (EBV) and especially prevalent in South East Asia at a rate of 15-50 cases per 100,000 people per year. In this project, we will study two NPC cohorts, a 51-participant new-diagnosis cohort and a 50-participant longitudinally sampled Phase II clinical trial cohort treated with the combination of anti-PD-1+anti-CTLA-4 (Ipilimumab+Nivolimumab) checkpoint blockade immunotherapy (cICI). With the goal better understanding the role of peripheral EBV-specific and other NPC-associated T cell responses in nasopharyngeal carcinoma (NPC) immunopathology, we will use a variety of single analysis methods applied to blood and tumor tissue to test the hypotheses that EBV-specific T cells contribute to tumor control elicited by cICI and that the phenotypic and clonal characteristics/dynamics of peripheral EBV-specific T cells can be useful as indicators of clinical outcomes for NPC patients.

PI_NAMEs: NEWELL, EVAN  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Adoptive Immunotherapy;Aftercare;American Association of Cancer Research;anti-CTLA4;anti-PD-1;anti-PD1 therapy;Biopsy;Biopsy Specimen;Blood;Blood specimen;Cancer Center;cancer diagnosis;CD8-Positive T-Lymphocytes;Cells;cellular imaging;Characteristics;Clinical;Clinical Trials;clinically relevant;Clone Cells;cohort;Cytometry;Data;Diagnosis;Enrollment;Epstein-Barr Virus-Related Malignant Neoplasm;exhaust;Far East;Freezing;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;genetic signature;Genetic Transcription;Goals;Head and Neck Cancer;HLA-DR Antigens;Human Herpesvirus 4;Immune;immune checkpoint blockade;Immune Evasion;Immune response;Immunohistochemistry;Immunologic Surveillance;Immunologics;immunopathology;Immunotherapeutic agent;Immunotherapy;immunotherapy trials;improved;Infiltration;insight;ipilimumab;Lymphocyte;Malignant Neoplasms;Mediating;Memory;Metastatic/Recurrent;Methods;multiple omics;Nasopharynx Carcinoma;Newly Diagnosed;novel;Outcome;Participant;Patient Selection;Patients;Pattern;Peptide/MHC Complex;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Phase II Clinical Trials;phase II trial;Phenotype;Population;Prevalence;programmed cell death ligand 1;protein expression;Publishing;response;Role;Sampling;Singapore;single cell sequencing;Sorting;Southeastern Asia;Stains;Survival Rate;T cell receptor repertoire sequencing;T cell response;T-Cell Activation;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Time;Tissues;tumor;tumor microenvironment;Tumor Tissue;Tumor-Infiltrating Lymphocytes;Validation;viral DNA;Virus Diseases

PROJECT_TITLE: The roles of EBV-specific T cells in response to checkpoint blockade immunotherapy of EBV-driven nasopharyngeal carcinoma

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Novel non-pharmacologic pain management approach of excruciating pain, as in pediatric burn dressing changes, is relevant to public health to prevent negative impacts on the delivery of optimal clinical care and the child’s post-injury recovery processes. The proposed randomized clinical trial of a smartphone VR for pain management during repeated at-home burn dressing changes addresses the U.S. Department of Health and Human Services priority to “advance better practices and cutting-edge research in pain management” and the AHRQ mission to “produce evidence to make health care safer, higher quality, more accessible, equitable, and affordable”.

PI_NAMEs: XIANG, HENRY  (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: A Randomized Clinical Trial of Smartphone Virtual Reality for Pain Management During Burn Care Transition

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE The goals of the Pregnant Female Reproductive Tissue Mapping Center are to develop three-dimensional multiscale maps of the placenta, pregnant uterine endomyometrium and fallopian tubes, to explore signaling between the placenta and maternal tissues, and to trace the trajectories of cellular differentiation and migration in the placenta across gestation. To do this, we will apply a range of imaging and molecular profiling modalities, including in vivo MRI and ultrasound imaging, and ex vivo extracellular matrix proteomics, formal histopathologic evaluation, imaging mass cytometry, single-nucleus multiomics, spatial transcriptomics and deep morphologic and hyperplex spatial immunoprofiling. The resulting data will be analyzed and distributed to the broader research community in collaboration with the HuBMAP Integration, Visualization, and Engagement (HIVE) Collaboratory. This project is relevant to public health because the resulting 3D multiscale maps of normal pregnant female reproductive tissues will serve as key frames of reference for future studies aiming to discover how perturbation of tissue structure and/or function leads to organ dysfunction in common, yet poorly understood, pregnancy complications, such as preeclampsia and preterm labor.

PI_NAMEs: LAURENT, LOUISE CHANG (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: 3-Dimensional;Adoption;Antibodies;ATAC-seq;Atlases;Award;Biological Assay;Biology;Blood;calcification;candidate identification;Cell Communication;cell component function;Cell Differentiation process;cell motility;Cell Nucleus;cell type;Cells;Chromatin;Circulation;Clinical;Clinical Data;cohort;Collaborations;collaboratory;Collection;Communication;Communities;Computational Biology;Cytometry;Data;Data Analyses;data harmonization;data integration;data management;Data Set;data sharing;data standards;Development;Discipline of obstetrics;Disease;Distant;diverse data;Endothelial Cells;Endothelium;Evaluation;extracellular;Extracellular Matrix;Female;Freezing;Functional disorder;Funding;Future;Generations;Goals;Grant;Gynecology;healthy pregnancy;Histologic;Histology;Hormone Responsive;Human;Human BioMolecular Atlas Program;human female;Image;image reconstruction;imaging modality;Immunoassay;Immunohistochemistry;in vivo;in vivo imaging;indexing;Inflammation;Infrastructure;innovation;interest;interoperability;Kidney;Lymphatic System;Magnetic Resonance;Magnetic Resonance Imaging;Mammalian Oviducts;Maps;Mediating;Metadata;metadata standards;Methods;Microscopic;migration;mimicry;Modality;Molecular;Molecular Profiling;Morphology;multiple data types;multiple omics;multiscale data;new technology;Normal tissue morphology;Nucleic Acids;Operative Surgical Procedures;Organ;Outcome;Pathology;Perfusion;Perinatal;Phase;Placenta;Placentation;Population;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;Pregnant Uterus;Pregnant Women;Premature Labor;preservation;Process;Proteomics;Public Health;Quality Control;recruit;reproductive;reproductive organ;Research;Research Infrastructure;Research Personnel;Resolution;Resource Sharing;RNA;Sampling;senescence;Signal Transduction;spatiotemporal;Structure;Study models;System;Techniques;Technology;Time;tissue mapping;Tissue Sample;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;trophoblast;Ultrasonography;ultrasound;Villous;Visualization;Work;XCL1 gene


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Immunotherapy;Lupus;Pediatric;Rheumatoid Arthritis

PI_NAMEs: KARLSON, ELIZABETH W (contact)

PROJECT_TERMS: Acceleration;Adolescent;Adult;Archives;Arthritis;arthritis registry;biobank;Bioinformatics;biological specimen archives;Biology;biomarker identification;Biometry;Biopsy;Blood;Body Fluids;Boston;Cancer Patient;Cells;Child;Childhood;Clinic;Clinical Trials;cohort;Collection;Communities;Complex;complex data;Consent;COVID-19;COVID-19 patient;Data;data management;Data Set;data sharing;Dedications;Development;Disease;Electronic Health Record;experience;Faculty;flexibility;genomic data;Genotype;genotyped patients;Health;Hospitals;Human;Human Resources;Immune checkpoint inhibitor;immune-related adverse events;Immunology;Inflammatory Arthritis;Infrastructure;Institution;Institutional Review Boards;Joints;Leadership;Link;Lupus;Medicine;meetings;member;Mission;Online Systems;Oranges;Patient Recruitments;Patients;Pediatric Hospitals;pediatric patients;pediatric rheumatic diseases;Phenotype;Positioning Attribute;Process;prospective;Prospective Studies;Protocols documentation;Psoriasis;Psoriatic Arthritis;Quality Control;Recontacts;recruit;Registries;Research;Research Personnel;Resources;Rheumatism;Rheumatoid Arthritis;Rheumatology;sample archive;Sampling;Services;Site;Source;Specific qualifier value;Statistical Data Interpretation;Stream;System;Systemic Lupus Erythematosus;tissue archive;Tissues;Translating;Translational Research;Woman;Work

PROJECT_TITLE: Human Biosamples Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Prevention

PHR: Project narrative Early-life risk factors have been implicated in inflammatory bowel diseases (IBD) but are not well-understood. There is increasing evidence of intestinal inflammation and loss of gut microbiome diversity preceding IBD. We aim to develop risk prediction models for IBD based on early-life risk factors and apply them toward prediction of intestinal inflammation and loss of microbiome diversity in order to better understand IBD pathogenesis, identify at-risk persons, and guide therapeutic and preventive efforts.

PI_NAMEs: AGRAWAL, MANASI  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 5 year old;Advisory Committees;Affect;American;Antibiotics;Area;Award;beta diversity;Biological Markers;Biometry;career;career development;Chronic;clinical care;clinical investigation;Clinical Research;cohort;Country;Crohn's disease;Data;Data Analyses;Data Science;Department chair;Digestive System Disorders;disability;Disease;disease diagnosis;disease transmission;disorder risk;Early Intervention;early life exposure;Environment;Epidemiology;Etiology;Event;Funding;Future;Gastroenterology;Gastrointestinal Diseases;Generations;Genetic;Genetic Risk;genome sciences;Goals;Grant;gut inflammation;gut microbiome;Health Care Costs;Immigrant;Immune;Immunologics;indexing;Individual;Infant;Infection;Inflammatory;Inflammatory Bowel Diseases;innovation;insight;International;Intestinal Diseases;K-Series Research Career Programs;Leukocyte L1 Antigen Complex;Life;Life course epidemiology;Longitudinal cohort;Maternal-Fetal Transmission;Mediating;medical schools;Mentors;Mentorship;Methodology;microbiome;model building;Modeling;Molecular Epidemiology;Morbidity - disease rate;Mothers;New York;news;non-genetic;novel;offspring;Onset of illness;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;patient oriented;Patients;Perinatal;Phase;population based;Populations at Risk;Positioning Attribute;pre-clinical;predictive marker;predictive modeling;Pregnant Women;prenatal;Prevention;Prevention strategy;Preventive;protein biomarkers;proteomic signature;Proteomics;Reporting;Research;Research Methodology;Research Personnel;Risk;Risk Factors;risk prediction;risk prediction model;Serum;skills;Socioeconomic Status;Techniques;Testing;Therapeutic;Time;timeline;Training;Training Activity;translational applications;Translational Research;Ulcerative Colitis;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Early-life Risk Factors for Inflammatory Bowel Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Human Genome;Prevention;Rare Diseases

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: NARRATIVE Colon cancer that is associated with a positive family history or early age of onset, and polyposis, the presence of multiple precancerous polyps in the colon, are two common indications for genetic testing for cancer risk assessment. We often cannot interpret DNA changes seen on testing; the goal of the proposed Polyposis /Colon Cancer Variant Curation Expert Panel (VCEP) is to create and maintain a panel of clinicians and scientists with broad expertise in all aspects of colon cancer and polyposis hereditary syndromes. The VCEP will analyze evidence on genetic in genes associated with Polyposis and Hereditary Colorectal Cancer, set rules for classifying the variants as disease-causing (pathogenic) or benign, and classify large numbers of variants that have been found through clinical genetic testing.

PI_NAMEs: GREENBLATT, MARC S (contact);TAVTIGIAN, SEAN VAHRAM

PROGRAM_OFFICER_NAME: KALIA, SARAH SUJATA

PROJECT_TERMS: Accounting;Address;Age of Onset;American;APC gene;Area;Benign;Bioinformatics;Biological Assay;BMPR1A gene;cancer genome;Classification;Clinical;clinical infrastructure;clinically relevant;clinically significant;ClinVar;Colon;Colon Carcinoma;Colorectal Cancer;colorectal cancer risk;Communities;Databases;Dedications;Development;Diagnosis;Discipline;Disease;DNA;DNA Databases;familial colorectal cancer;Family;Funding;Future;gastrointestinal;gene panel;gene repair;Genes;Genetic;genetic counselor;Genetic Diseases;genetic panel test;genetic testing;Genetic testing for cancer risk;genetic variant;Genome;Genomics;Germ-Line Mutation;Goals;Hereditary Malignant Neoplasm;Hereditary Nonpolyposis Colorectal Neoplasms;Human Resources;in silico;Individual;informatics infrastructure;Inherited;insight;International;international scientific organization;Link;MADH4 gene;Malignant neoplasm of gastrointestinal tract;Medical Genetics;medical schools;member;Mismatch Repair;molecular diagnostics;molecular pathology;multidisciplinary;Oncogenes;Participant;Pathogenicity;Pathology;Patients;Phenotype;polyposis;Precancerous Polyp;precision medicine;premalignant;Procedures;Qualifying;Recording of previous events;Reporting;Research;Research Personnel;Resources;Risk Assessment;risk variant;Scientist;Societies;Specific qualifier value;STK11 gene;Structure;Susceptibility Gene;Syndrome;System;Testing;Time;tool;Training;tumor;United States National Institutes of Health;Variant;variant of unknown significance;working group

PROJECT_TITLE: InSiGHT-ClinGen Polyposis/Colon Cancer Variant Curation Expert Panel

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-K(50)R]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Pediatric

PHR: Project Narrative Pediatric Pulmonary Medicine is one of the smallest pediatric subspecialties. Very few pediatric pulmonologists have had adequate training and mentorship in research, and thus lack the skills to perform cutting-edge research in pediatric pulmonary diseases. This training grant will continue to educate a new generation of pediatric pulmonologists and Ph.D. scientists, who can play a role as leaders and researchers in pediatric pulmonary medicine.

PI_NAMEs: CELEDON, JUAN CARLOS (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Childhood;Grant;Pulmonology;Training

PROJECT_TITLE: Pittsburgh Training Grant in Pediatric Pulmonary Medicine

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: TOMARAS, GEORGIA DORIS (contact)

PROJECT_TERMS: Active Immunization;Animals;Antibodies;antibody-dependent cell cytotoxicity;Autopsy;Biodistribution;Blood;Cell Communication;cell type;Cells;Collaborations;differential expression;Disparate;Dose;Drug Kinetics;Drug or chemical Tissue Distribution;Effector Cell;Environment;Event;Fc Receptor;FCGR3B gene;female reproductive tract;gastrointestinal;Genetic;Heterogeneity;HIV;HIV Antibodies;HIV-1;Human;IgG3;Immunoglobulin A;Immunoglobulin G;Immunoglobulins;In Situ;In Vitro;in vivo;Individual;Infection;Infusion procedures;insight;Interruption;Label;Length;Lentivirus;Macaca mulatta;Mediating;Mediator;Modeling;Monitor;Monoclonal Antibodies;monocyte;mucosal site;Mucous Membrane;Natural Killer Cells;neutralizing antibody;nonhuman primate;novel;Passive Immunization;PET/CT scan;Phagocytosis;Phase;Phenotype;Plasma;Play;Population;prevent;Process;Property;receptor expression;recruit;Role;sample collection;Signal Transduction;simian human immunodeficiency virus;SIV;Specificity;synergism;System;Testing;Therapeutic;Time;Tissues;trafficking;transcriptomics;transmission process;vaccination strategy;vaccine response;vaccine trial;Vaccines;Viral;Viral Antibodies;Viral Physiology;Viremia;Virus Replication

PROJECT_TITLE: Antiviral Activity In Situ


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Glioblastoma (GBM) is the most devastating and aggressive brain tumor in adults, with a median survival of only 14.6 months. The project will use a novel lipid nanoparticle that has the ability to penetrate blood vessels in tumors, in order to deliver drug therapies to aggressive invasive cells in gliomas.

PI_NAMEs: BALYASNIKOVA, IRINA V;SIMBERG, DMITRI  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Abbreviations;Adult;Animals;Antibodies;Antigens;Apoptosis;Biodistribution;Blood;Blood Vessels;blood-brain tumor barrier;Brain;Brain Neoplasms;brain tissue;cell motility;Cells;Chemistry;clinical translation;CRISPR/Cas technology;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinases;Data;delivery vehicle;Dextrans;Diffusion;Disease;Dose;Drug Delivery Systems;Drug Kinetics;Endocytosis;Endothelial Cells;Endothelium;Exhibits;Exocytosis;extracellular vesicles;Extravasation;Flow Cytometry;fluorescence lifetime imaging;fluorophore;Formulation;Foundations;Genetically Engineered Mouse;Glioblastoma;Glioma;Goals;Image;improved;In Situ;In Vitro;in vivo;inhibitor;Injections;innovation;Invaded;knock-down;Libraries;Ligands;Lipid Chemistry;lipid nanoparticle;lipid structure;Lipids;lipophilicity;Liposomes;Mediating;migration;Modeling;Mus;Myeloid Cells;nanoformulation;nanomedicine;nanoparticle;nanoparticle delivery;neoplastic cell;novel;novel strategies;Organoids;particle;Pathway interactions;Patients;Penetration;Perfusion;Pharmaceutical Preparations;Pharmacotherapy;Phospholipids;Population;Process;Prodrugs;Radiation therapy;Recurrence;Reporting;Resistance;Role;small molecule;Solid Neoplasm;Source;spatiotemporal;Specificity;Structure;success;Testing;Therapeutic;tool;trafficking;transcytosis;Treatment Efficacy;Treatment outcome;tumor;tumor-immune system interactions;uptake

PROJECT_TITLE: Fluorescent Indocarbocyanine PEGylated Lipid Nanoparticles for Understanding and Overcoming Barriers to Drug Delivery in Invasive Glioblastoma


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Lupus

PI_NAMEs: LEDERER, JAMES A. (contact)

PROJECT_TERMS: Acceleration;Adoption;Animals;Antibodies;antibody conjugate;antibody libraries;Antigens;Area;Arthritis;assay development;ATAC-seq;Autoantigens;B cell repertoire;B-cell receptor repertoire sequencing;Basic Science;Big Data;Bioinformatics;Biology;Boston;Categories;cell dimension;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;Computational Biology;Computer Analysis;Computing Methodologies;CRISPR screen;Custom;Cytometry;Data;Data Analyses;Data Science;Data Set;design;Detection;Development;Disease;DNA sequencing;Education;Ensure;Experimental Designs;Face;Genomic DNA;Genomics;Goals;high dimensionality;Hospitals;Human;Immunology;Immunophenotyping;Individual;Infrastructure;innovation;Investments;Joints;Laboratories;Lead;Liquid substance;Lupus;Mass Spectrum Analysis;Medical;Medicine;member;Methodology;Methods;Mission;next generation sequencing;Pathologist;Pediatric Hospitals;Phage ImmunoPrecipitation Sequencing;Preparation;programs;Proteins;proteogenomics;Research;Research Personnel;Resources;Rheumatoid Arthritis;rheumatologist;Rheumatology;Sampling;Scanning;service delivery;Services;single cell genomics;single-cell RNA sequencing;skills;structured data;success;System;Systemic Lupus Erythematosus;T cell receptor repertoire sequencing;T-Lymphocyte;Techniques;Technology;Testing;Time;tissue preparation;tissue processing;Tissues;tool;transcriptome sequencing;transcriptomics;Translational Research;translational scientist;Woman

PROJECT_TITLE: Cellular Systems Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

PHR: PROJECT NARRATIVE This proposal addresses the public health issues of the growing number of seriously ill older adults with serious illness. It will create an infrastructure for translational research in geriatric palliative care that will train new investigators, create new data and analysis resources, and support projects that will lead to innovations in care of this high-need population.

PI_NAMEs: MORRISON, R. SEAN;SIU, ALBERT L (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Academy;Acute;Address;Adoption;Adult;Age;Aging;American;Antibiotics;Behavioral;Brain Diseases;Capsicum;care fragmentation;care systems;Caregivers;Caring;Cessation of life;Chronic;Chronic Care;Chronic Disease;Chronically Ill;Clinical;cognitive performance;Collaborations;Communication;Confusion;Consultations;continuing medical education;Data;Data Management Resources;Degenerative Disorder;Dementia;Device or Instrument Development;Diagnosis;Disease;Distress;education research;Effectiveness;Elderly;end of life;evidence base;experience;Family;Family Caregiver;family support;Foundations;frailty;Functional dependence;Funding;Generations;Geriatrics;graduate medical education;Growth;Health;Health Services Research;Healthcare;Healthcare Systems;Heart Diseases;Human;human old age (65+);improved;Individual;Infrastructure;innovation;Leadership;Life;Longevity;Lung Diseases;Malignant Neoplasms;Measurement;Measures;Medical;medical specialties;Medicine;Mentors;metastatic colorectal;Methods;Minority;Mission;Modeling;Modern Medicine;Movement;Names;neglect;neuromuscular;older adult;Older Population;Organ;Palliative Care;Patients;physical symptom;Physicians;Pilot Projects;Population;population based;Population Growth;Population Research;preference;programs;psychological symptom;Public Health;Quality of Care;Quality of life;Recording of previous events;recruit;Reporting;Research;research and development;Research Design;Research Infrastructure;Research Methodology;Research Personnel;research to practice;Research Training;Resources;response;Scoring Method;Service delivery model;Societies;Stroke;Support System;Talents;Techniques;Testing;theories;Time;Training;Training Programs;Translational Research;Translations;undergraduate medical education;Work

PROJECT_TITLE: Enhancing Independence in Elders with Serious Illness


NIH_SPENDING_CATS: Cancer

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: PROJECT NARRATIVE This is a new application for an NCI-supported cancer control training in disparities and equity in South Florida (South Florida C-TIDE). This multidisciplinary program proposes to train postdoctoral fellows in multilevel determinants (e.g., biological, medical, social, psychosocial, health systems) of cancer risk, etiology, progression, cancer prevention and care delivery, health-related quality of life, and other patient-reported outcomes. The primary goal of the program is to train the next generation of researchers with an exceptional training platform that supports postdoctoral fellows across the cancer control continuum as they develop independent, successful, high-impact research targeting cancer disparities and health equity.

PI_NAMEs: KOBETZ, ERIN N;PENEDO, FRANK J (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Cancer Training in Disparities and Equity (C-TIDE)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Contraception/Reproduction;Data Science;Networking and Information Technology R&D (NITRD);Women's Health Research

PI_NAMEs: FISCH, KATHLEEN MARIE (contact)

PROJECT_TERMS: 3-Dimensional;Adopted;Agreement;analysis pipeline;Anatomy;Architecture;Area;Atlases;Biological Assay;Cell Communication;Cell Differentiation process;cell motility;Cell Nucleus;cell type;Cells;Cellular Structures;Clinical;Collaborations;collaboratory;Collection;Computer software;computerized data processing;Data;Data Analyses;data analysis pipeline;data exchange;data format;data integration;data modalities;data quality;Data Set;data standards;data submission;Development;Emerging Technologies;Ensure;extracellular;Extracellular Matrix;FAIR principles;feature selection;Female;flexibility;Funding;Human BioMolecular Atlas Program;Human body;Image;imaging modality;Immunohistochemistry;in vivo imaging;indexing;Individual;interoperability;Link;Mammalian Oviducts;Maps;Mediating;Metadata;metadata standards;migration;Modality;Molecular;Morphology;multiple data types;multiscale data;Organ;organ growth;Pathologic;Placenta;Placentation;Policies;Pregnancy;pregnant;Procedures;programs;protein expression;Quality Control;reproductive;RNA;Sampling;secondary analysis;Signal Transduction;single nucleus RNA-sequencing;spatial integration;spatiotemporal;Structure;Surveys;Techniques;tissue mapping;Tissue Model;Tissues;tool;Touch sensation;Transcript;transcriptomic profiling;United States National Institutes of Health;Uterus;Visualization

PROJECT_TITLE: Pregnant Female Reproductive Tissue Mapping Center Data Analysis Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-U]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Digestive Diseases;Genetics;Human Genome

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Up to 20% of patients with diabetes mellitus have gastrointestinal symptoms. These symptoms are often distressing and may impair glycemic control. Our studies are designed to improve our understanding of why these symptoms occur in these patients and thereby identify new treatment(s) in the future.

PI_NAMEs: BHARUCHA, ADIL E. (contact);ORDOG, TAMAS

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Affect;Autonomic nervous system;Behavior;bench to bedside;Biopsy;cell type;Cells;Chromatin;Chronic;Collaborations;Complement;Complications of Diabetes Mellitus;Data;design;Diabetes Mellitus;diabetic;diabetic gastroparesis;Disease;Distress;Duodenum;Endocrine;Enteral;Epigenetic Process;epigenome;epigenomics;experimental study;Functional disorder;Future;Gastrectomy;Gastric Emptying;gastrointestinal symptom;Gastroparesis;Gene Expression;Genes;genome-wide;glycemic control;Growth Factor;Harvest;Histologic;histone modification;Human;Hyperglycemia;IGF1 gene;Immune;Immunity;Immunophenotyping;Impairment;improved;in vivo;ineffective therapies;Inflammatory;inflammatory milieu;insulin signaling;Interstitial Cell of Cajal;Leukocytes;Link;Metabolic;Mission;Mitochondria;mitochondrial dysfunction;Molecular;Mus;Muscle;Natural Immunity;Neurons;nitrosative stress;nonulcer dyspepsia;novel marker;Nuclear;Organ;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Phenotype;prevent;Proteomics;PTPRC gene;repository;Role;Signal Pathway;Smooth Muscle;Stomach;Symptoms;Thick;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Upper digestive tract structure

PROJECT_TITLE: Single-cell epigenomics and transcriptomics of diabetic gastroparesis in humans


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Palliative Care

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PI_NAMEs: GOLDSTEIN, NATHAN E (contact)

PROJECT_TERMS: academic program;Accountability;Address;advanced disease;Advisory Committees;Affect;Alzheimer's disease related dementia;American;Attention;Behavioral;career;Career Choice;career development;Career Mobility;Caregivers;Caring;Chronic Disease;Clinical;Clinical Medicine;Collaborations;cost;Dedications;Dementia;design;Development;Development Plans;Discipline;Disease;education research;Educational Activities;Educational Curriculum;Elderly;Elements;Ethics;Evaluation;evidence base;experience;Faculty;faculty support;Family;Foundations;fundamental research;Funding;Future;Geriatrics;Goals;graduate school;Grant;Health;Health Services Research;Health system;improved;Individual;Institute of Medicine (U.S.);Institution;interest;investigator training;K-Series Research Career Programs;Leadership;Letters;Life;Medical;medical schools;Medicine;Mentors;Mentorship;Methods;Monitor;multidisciplinary;Nursery Schools;older adult;Palliative Care;Palliative Medicine;Patients;Persons;Process;programs;Quality of Care;Quality of life;recruit;Reporting;Research;research and development;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;research study;Resources;Role;satisfaction;skills;statistics;Structure;success;symptomatic improvement;Talents;Time;Training;United States National Institutes of Health;Wages;webinar;Work

PROJECT_TITLE: Research Education Component (REC)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Maternal Health;Pediatric;Pregnancy;Women's Health Research

PI_NAMEs: PARAST, MANA M (contact)

PROJECT_TERMS: 3-Dimensional;adverse pregnancy outcome;Architecture;ATAC-seq;Atlases;Biological;Biological Assay;Blood;Blood specimen;candidate identification;Capillary Endothelial Cell;cell motility;Cell Nucleus;Cell Physiology;cell type;Cells;Chromatin;Circulation;Collaborations;Collection;Communication;Communities;Cytometry;cytotrophoblast;Data;data integration;Data Set;data sharing;design;Detection;Development;digital;Endocrine;Enrollment;Ensure;extracellular;Extracellular Matrix;Female;fetal;Fetal Growth;Fetus;fetus cell;Functional disorder;Future;Generations;Giant Cells;Goals;healthy pregnancy;Histopathology;Hormones;Human;Human BioMolecular Atlas Program;human female;Image;imaging study;Immune;Immune response;Immunoassay;In Situ;in vivo;Infection;interest;Knowledge;life span;Link;Magnetic Resonance Imaging;Mammalian Oviducts;Maps;maternal serum;Mediating;Metabolic;metabolomics;Metadata;migration;Molecular;Molecular Analysis;Molecular Profiling;Mothers;multiple data types;novel;Nutrient;Organ;Participant;Performance;Placenta;Placentation;Play;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Maintenance;pregnant;Premature Birth;prenatal;Proteins;Proteomics;recruit;Reproducibility;reproductive;Resolution;Resource Sharing;RNA;Role;Sampling;sex;Signal Pathway;Signal Transduction;spatiotemporal;Stains;Stromal Cells;Study Subject;Surveys;Syncytiotrophoblast;System;Techniques;Technology;Time;tissue mapping;Tissue Model;Tissue Sample;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomics;trophoblast;Ultrasonography;ultrasound;Uterus;Villous;wasting;Work

PROJECT_TITLE: Pregnant Female Reproductive Tissue Mapping Center Organ Specific Project


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: MOUNTAIN VIEW

ORG_NAME: LYMPHAXIS, INC.

PHR: Building on a half-century of innovation in transvascular access and ultrasound image guidance, LXS has developed a novel catheter device and venous access procedure to cannulate and aspirate the thoracic duct under ultrasound guidance. The company is applying for a Commercialization Readiness Pilot (CRP) award to complete development, prepare and submit for FDA clearance, ramp manufacturing, and create sales and marketing strategies in anticipation of commercial use. Completion of this CRP program will place the company in a position to launch sales with an FDA cleared device as a direct competitor to plasmapheresis and the only transvascular access device for lymphocyte collection and depletion.

PI_NAMEs: CALLAGHAN, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Animals;aspirate;Autoimmune Diseases;Award;Basic Science;biomaterial compatibility;Blood Vessels;Cadaver;Cannulations;Cardiovascular system;Catheters;Cell Therapy;cell type;Cells;Characteristics;chimeric antigen receptor T cells;Clinical;clinical application;Clinical Medicine;Clinical Research;Collaborations;Collecting Cell;Collection;commercialization readiness;Communicable Diseases;Complex;Complication;Consumption;Contracts;cost;Data;design;Development;Devices;Diabetes Mellitus;Disease;Engineering;first-in-human;flexibility;Funding;gastrointestinal;Goals;Harvest;Heart failure;human study;image guided;improved;innovation;interest;Internal jugular vein structure;Intervention;Left;Legal patent;Liquid substance;Lymphatic;Lymphatic System;lymphatic vessel;Lymphocyte;Malignant Neoplasms;manufacture;manufacturing test;Marketing;Medicine;meetings;Methods;miniaturize;minimally invasive;Modeling;novel;Oncology;Pathway interactions;Performance;Perfusion;Peripheral;peripheral blood;Peripheral Blood Lymphocyte;Phase;Plasmapheresis;Play;point of care;Positioning Attribute;post-market;pre-clinical;Procedures;Production;programs;Protocols documentation;Ramp;Reporting;Research;Resources;Role;Sales;Series;Small Business Innovation Research Grant;Sterility;Structure of subclavian vein;success;System;Techniques;Testing;Therapeutic;Thoracic Duct;Time;Torque;Training;Translational Research;Trust;Ultrasonography;ultrasound;United States National Institutes of Health;Update;Venous;Venous system;verification and validation;Work

PROJECT_TITLE: Minimally invasive access and aspiration of circulating lymphocytes from the thoracic duct


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Dissemination and Implementation Research;Neurodegenerative;Palliative Care

PI_NAMEs: SIU, ALBERT L (contact)

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Capsicum;Caregivers;Caring;Clinical Research;clinical translation;Collaborations;Communication;Data;Data Sources;Dementia;Development;education research;Elderly;experience;Faculty;Family;Fellowship;Fostering;Geriatrics;Goals;Grant;Health;human subject;implementation science;improved;innovation;Institution;Instruction;Investments;Knowledge;Leadership;longitudinal course;Measurement;medical schools;Mentors;Methodology;Methods;Minority;Monitor;Network-based;older adult;Older Population;Palliative Care;Phase;Pilot Projects;Population;Population Research;Prevalence;process improvement;programs;Research;Research Activity;research and development;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Serious Adverse Event;Translating;Translations;Vision;Work

PROJECT_TITLE: Leadership and Administrative Core (LAC)


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Ovarian Cancer;Rare Diseases;Uterine Cancer;Women's Health Research

ORG_NAME: UNIVERSITY OF IOWA

PHR: Project Narrative / Public Health Relevance Statement p53 is a foundational mutation in many cancers, with mutations found in >90% of ovarian cancer and >70% of endometrial cancer. However, p53 has proven to be a challenging target in the therapeutic arena. This project will define the deleterious actions of common mutations in p53 and develop novel synthetic RNA-based therapeutics to perturb each mutant's aberrant activity.

PI_NAMEs: THIEL, KRISTINA W (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Affinity;Amino Acids;Antibodies;aptamer;biobank;Biochemistry;Bioinformatics;Biological Assay;biophysical model;cancer type;Cell Cycle;Cell Cycle Progression;Chemoresistance;chemotherapy;Clinical;Clinical Trials;cofactor;Collaborations;combinatorial;Complex;CRISPR/Cas technology;Data;design;Development;Discipline of obstetrics;DNA Binding;DNA Binding Domain;drug testing;effective therapy;efficacy testing;Endometrial;Endometrial Carcinoma;Environment;Evolution;Faculty;Funding;Gene Expression Regulation;gene therapy;Genes;Genetic Transcription;genomic locus;Genomics;Goals;Gynecology;improved outcome;In Vitro;Individual;innovation;Institution;Iowa;K22 Award;Left;Length;Libraries;Ligands;Link;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;MAP Kinase Gene;Maps;Mentors;Methodology;Missense Mutation;Modeling;Molecular;multidisciplinary;mutant;Mutation;next generation sequencing;novel;novel strategies;Null Lymphocytes;Oligonucleotides;Organoids;Ovarian Tissue;p38 Mitogen Activated Protein Kinase;Patient-Focused Outcomes;Patients;personalized medicine;Phase;Positioning Attribute;post-doctoral training;Post-Translational Protein Processing;Postdoctoral Fellow;programs;Protein Conformation;Protein Isoforms;protein protein interaction;Proteins;public health relevance;Randomized;Recurrence;Regimen;Research;Research Assistant;response;RNA;RNA Splicing;Scientist;Signal Transduction;Single Nucleotide Polymorphism;Site;Specificity;synergism;taxane;tenure track;Testing;Therapeutic;therapeutic RNA;three dimensional structure;tool;TP53 gene;transcriptome sequencing;transcriptomics;translational study;Treatment Protocols;Universities;Woman;women's outcomes;Work

PROJECT_TITLE: Attacking aggressive p53 mutants in gynecologic cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pain Research;Palliative Care

PI_NAMEs: BOOCKVAR, KENNETH S. (contact)

PROJECT_TERMS: Address;Aging;Alzheimer's disease patient;Alzheimer's disease related dementia;anxiety treatment;Applications Grants;Award;beneficiary;Capsicum;career;career development;Caregiver Burden;Caregivers;Caring;Chronic Disease;Chronic Obstructive Pulmonary Disease;clinical center;Conflict (Psychology);Data;Dementia;dementia care;design;Development;disability;Discipline;Distress;education research;Elderly;evidence base;experience;Experimental Designs;Faculty;Family;feasibility testing;follower of religion Jewish;Fostering;Foundations;Funding;Funding Agency;Future;Generations;Geriatrics;Goals;Grant;Head and Neck Cancer;Health;health care disparity;Home;implementation science;improved;Individual;Institution;Interdisciplinary Study;Intervention;K-Series Research Career Programs;Leadership;Malignant neoplasm of liver;medical specialties;Medicare;Methodology;Methods;Minority;Monitor;Neurology;Nursery Schools;older adult;older patient;outreach;Pain;palliative;Palliative Care;Patients;Perception;Performance Status;Persons;Pilot Projects;pilot test;population based;population health;Predisposing Factor;programs;Provider;Psychiatry;Publications;Qualitative Methods;Quality of life;Quasi-experiment;Radiation;Research;Research Institute;Research Personnel;Research Project Grants;Research Support;response;senior faculty;Signal Transduction;Source;Surveys;Symptoms;System;Testing;Translational Research;trend;Triage;Universities;Woman;Work

PROJECT_TITLE: Pilot and Exploratory Studies Core (PESC)


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Social Determinants of Health

ORG_NAME: VETERANS HEALTH FOUNDATION

PHR: PROJECT NARRATIVE Aphasia, a language disorder commonly caused by stroke, affects more than 2 million Americans and interferes with everyday communication, disrupts participation in work and preferred activities, and significantly reduces health-related quality of life. The proposed conference grant will support a set of cutting-edge presentations to help professionals improve the study and treatment of aphasia, with a focus on health disparities. The grant will also support student training in aphasia research and treatment.

PI_NAMEs: HULA, WILLIAM D. (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Affect;American;Aphasia;Aphasiology;Area;Brain Injuries;Budgets;cardiovascular health;career;Caring;Clinical;Clinical assessments;Clinical Investigator;Clinical Research;Clinical Treatment;Clinical Trials;clinically relevant;Cognitive;Communication;Communities;community based participatory research;Dedications;design;Development;disability;Disability status;disadvantaged background;Disease;Elements;Ethnic Population;Evaluation;experience;Fellowship;Gender;Goals;Grant;health care disparity;Health Disparities Research;health disparity;health related quality of life;Hearing;Impairment;improved;Individual;Inequity;innovation;Knowledge;Language;Language Disorders;Link;Location;meetings;member;Mentors;Methods;Neurogenic Communication Disorders;Neurologist;older adult;Participant;Pathologist;Public Health;racial health disparity;racial population;recruit;Recruitment Activity;Request for Applications;Research;Research Personnel;Research Project Grants;Schedule;Sex Orientation;social;social health determinants;Speech;Stroke;student participation;student training;Students;symposium;theories;Travel;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Work

PROJECT_TITLE: Research Symposium in Clinical Aphasiology

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Mental Health;Microbiome;Neurosciences

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative The complex consortia of bacteria and other microbes carried by all eukaryotic organisms, collectively referred to as the microbiota, has been shown to have critical roles in many aspects of human health and disease including inflammatory bowel disease and cancer. An evolving literature has recently shown that these findings extend to the central nervous system, and disruptions in the microbiota have been shown to alter fundamental processes including fear extinction, experience-dependent synaptic plasticity, and microglial maturation. This research proposal will identify how the microbiota regulate neuron-microglia interactions including synaptic engulfment, and the microbiota-to-brain signals that do so, with the long-term goal of advancing new treatments for dysbiosis-induced cognitive dysfunction.

PI_NAMEs: PARKHURST, CHRISTOPHER NEAL (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acute;Adult;Affect;Affective;Animal Behavior;Animals;Antibiotic Therapy;Antibiotics;Asthma;Bacteria;Behavior;behavioral outcome;Biological Assay;Birth;Body System;Brain;brain tissue;career;career development;Cells;Central Nervous System;cognitive function;Complement;Complement Receptor;Complex;conditioned fear;Correlation Studies;Critical Pathways;Cues;Data;Defect;Dendritic Spines;Development;Disease;dysbiosis;experience;experimental study;Extinction;Failure;Fright;Functional disorder;Genes;Genetic Transcription;Germ-Free;Goals;Health;Human;human model;Impaired cognition;Impairment;In Vitro;in vivo;Inflammatory Bowel Diseases;insight;instructor;Literature;Macrophage;Macrophage-1 Antigen;Maintenance;Malignant Neoplasms;Medial;Mediating;Medical center;Medicine;Mentorship;metabolomics;Microbe;microbial;microbiome;microbiome alteration;microbiome research;microbiota;microbiota metabolites;Microglia;Modeling;Mus;Nervous System Physiology;Neurodegenerative Disorders;Neurons;neuropsychiatric disorder;normal microbiota;novel;Organism;Pathology;Peripheral;Peripheral Blood Mononuclear Cell;Phagocytosis;Phenotype;Physicians;Physiology;Population;Positioning Attribute;postnatal;Prefrontal Cortex;Process;Program Development;Proteins;Publishing;Regulation;Research;Research Proposals;response;Role;Scientist;Signal Transduction;Signaling Molecule;single nucleus RNA-sequencing;skills;small molecule;Synapses;Synaptic plasticity;synaptic pruning;Testing;Tissues;Training;transcriptome;transcriptomics;two-dimensional;Vertebral column;Virus Diseases;Work

PROJECT_TITLE: Microbial Regulation of Microglial Function

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Dissemination and Implementation Research;Neurodegenerative;Palliative Care

PI_NAMEs: ALDRIDGE, MELISSA DIANE (contact)

PROJECT_TERMS: Address;aging related;Alzheimer's disease related dementia;American;Area;beneficiary;career;caregiving;Cessation of life;cohort;Cohort Analysis;Collaborations;comorbidity;consent capacity;Consultations;Cost Analysis;Data Analyses;Data Set;Database Management Systems;Databases;Dementia;design;Development;Diagnosis;Effectiveness;Elderly;experience;Faculty;Formulation;Foundations;functional disability;Funding;Future;Goals;Grant;Growth;Healthcare;Heart failure;Home;implementation science;improved;Infrastructure;infrastructure development;innovation;instrument;Intervention;Knowledge;longitudinal analysis;Longitudinal Studies;Measures;medical schools;Medicare;Medication Management;Mentors;Mentorship;Methodology;Mission;Modeling;multiple chronic conditions;Observational Study;older adult;Outcome;Palliative Care;patient subsets;Patients;Performance Status;Phase;Physical Function;physical symptom;pilot test;population based;Population Database;Population Research;Process;Productivity;Program Development;programs;psychological symptom;Qualitative Methods;Quality of life;Research;research and development;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Training;Resources;Risk;success;Surveys;time use;Training;Training Activity;Training Programs;Training Support;Work

PROJECT_TITLE: Population Research and Methods (RC-PRM)


NIH_SPENDING_CATS: Genetics

ORG_CITY: LEXINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE While females and males have many similarities, both sexes have unique biology with clear differences in disease prevalence, therapeutic needs, and responses. Females, in particular, have not received adequate attention in human health and disease research. We seek to better understand how structural variants and individual RNA isoforms affect disease by helping to characterize them and their roles in human health and disease.

PI_NAMEs: EBBERT, MARK T W (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;Attention;autism spectrum disorder;Biology;Code;Crohn's disease;Disease;Female;Genes;Genome;Goals;Haplotypes;Health;HLA Antigens;Human;Individual;interest;Major Histocompatibility Complex;male;Malignant Neoplasms;Mutation;Neurodegenerative Disorders;personalized medicine;Prevalence;Protein Isoforms;Proteins;reference genome;Research;response;RNA;Role;Schizophrenia;sex;Sex Differences;Structure;Technology;Therapeutic;transcriptome sequencing;Variant

PROJECT_TITLE: Understanding how structural mutations and individual RNA isoforms are involved in human health and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Palliative Care

PI_NAMEs: KELLEY, AMY STEVES (contact)

PROJECT_TERMS: Address;adverse outcome;Aging;Algorithms;Alzheimer's disease related dementia;American;beneficiary;Capsicum;career development;Caregivers;Caring;Characteristics;Clinical Research;Cognitive;cohort;Collaborations;Communities;comorbidity;Complement;cost;Data;data access;data management;Data Set;Data Sources;data warehouse;Dementia;Development;Disease Progression;Economics;education research;Elderly;Electronic Health Record;end of life;Ensure;Equipment and supply inventories;Evaluation;experience;Faculty;Family health status;follow-up;Funding;Goals;Health;Health and Retirement Study;health care service utilization;Home;implementation science;improved;Infrastructure;innovation;interest;K-Series Research Career Programs;Link;Longitudinal cohort;longitudinal course;Measurement;Measures;Medical;Medicare;Medicare claim;Medicare/Medicaid;Methodology;Methods;older adult;Palliative Care;Patient Self-Report;Patients;Persons;Pilot Projects;Policy Maker;Population;population based;Population Research;Population Study;Probability;prospective;Quality of life;Research;research and development;research faculty;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Sample Size;skills;social;trend;Update;Veterans Health Administration;Work

PROJECT_TITLE: Population Data Use and Management (RC-PDM)


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: DAVIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE Nuclear RNA export, an essential process required to use information stored within DNA, is disrupted in multiple diseases and is targeted by viruses to benefit viral replication and survival. The proposed research is focused on understanding the mechanistic basis of RNA export via nuclear pore complexes. This will provide fundamental knowledge necessary for understanding disease, which is core to the mission of NIH and NIGMS.

PI_NAMEs: MONTPETIT, BENJAMEN H.W. (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Architecture;Biology;Cytoplasm;Data;Disease;DNA;Eukaryota;Event;Gene Expression;Genetic Transcription;Goals;Homeostasis;Human;Induced Mutation;Knowledge;Link;Mediating;Meiosis;Messenger RNA;Methodology;Mission;Molecular;mRNA Export;Mutation;National Institute of General Medical Sciences;novel;Nuclear;Nuclear Export;Nuclear Pore Complex;Nuclear RNA;Pathway interactions;Polyadenylation;Process;programs;protein complex;Proteins;Regulation;Research;RNA;RNA Decay;RNA Processing;RNA Splicing;RNA Transport;RNA-Binding Proteins;RNA-Protein Interaction;Role;Structure;TAF15 gene;Technology;Transcript;Transfer RNA;Translations;United States National Institutes of Health;Untranslated RNA;Virus;Virus Replication

PROJECT_TITLE: Mechanism and regulation of nuclear RNA export

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Cancer;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative Identifying biomarkers for response to treatment in Diffuse Large B cell Lymphoma (DLBCL) is important for public health because there is a strong need to improve patient outcomes through targeted treatment strategies. BCL10 is recurrently mutated in DLBCL and upregulates oncogenic signaling pathways, conferring resistance to key therapies. Elucidating the mechanism of BCL10 mutations in lymphomagenesis and their impact on response to treatment is relevant to the NCI’s mission because it may reveal novel molecular mechanisms and inform therapeutic approaches and clinical decision-making in particular subtypes of DLBCL.

PI_NAMEs: COUGHLIN, CAROLINE ALICE (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Agammaglobulinaemia tyrosine kinase;alternative treatment;American;Automobile Driving;B lymphoid malignancy;B-Cell Activation;B-Lymphocytes;BCL10 gene;BCL6 gene;Biochemical;Biological;Biological Markers;biomarker identification;career;Cell Line;Cells;Chronic Lymphocytic Leukemia;Classification;Clinical;clinical decision-making;clinical heterogeneity;Clinical Trials;Complex;Cyclophosphamide;Data;Dependence;Diagnosis;Disease;disorder subtype;Doxorubicin;Drug resistance;Drug Targeting;Exhibits;experimental study;Genetic;Genetic Recombination;genetic regulatory protein;Goals;Hematologic Neoplasms;human disease;Immuno-Chemotherapy;improved;improved outcome;In Vitro;in vivo;in vivo Model;Incidence;innovation;Intrinsic factor;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;Lead;Lymphoma;Lymphoma cell;Lymphomagenesis;MAPK8 gene;Mature B-Lymphocyte;Mediating;Mission;Modeling;Molecular;mouse model;Mucosa- associated lymphoid tissue lymphoma translocation protein-1;Mus;Mutate;Mutation;Nature;NF-kappa B;Non-Hodgkin's Lymphoma;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Organ;Outcome;overexpression;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Physicians;pre-clinical;Prednisone;Prognosis;Public Health;Recurrence;Refractory;Relapse;Research;Resistance;resistance mechanism;response;response biomarker;rituximab;Role;Scientist;Signal Pathway;Signal Transduction;skills;small molecule;Survival Analysis;synergism;System;targeted treatment;Testing;Therapeutic;Therapeutic Studies;therapeutic target;treatment response;treatment strategy;tumor;Tyrosine Kinase Inhibitor;Vincristine

PROJECT_TITLE: Overcoming Drug Resistance Driven by BCL10 Mutations in Diffuse Large B Cell Lymphoma


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Palliative Care;Racial and Ethnic Minority Health Research

PI_NAMEs: TERESI, JEANNE A. (contact)

PROJECT_TERMS: acute care;Address;advanced disease;aged;Aging;allostatic load;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Anxiety;Area;Biological Markers;Capsicum;Caregiver Burden;Caregivers;caregiving research;Caring;Cognition;Collaborations;Communities;computerized;Consult;Consultations;Data;Data Set;Dementia;Development;education research;Elderly;ethnic difference;ethnic diversity;Ethnic Origin;Evaluation;fall risk;Family member;Funding;Future;Goals;health difference;Hispanic;Hispanic Populations;Impaired cognition;implementation outcomes;improved;Individual;Information Systems;interest;Language;Latino;Leadership;Link;Malignant Neoplasms;Measurement;Measures;member;Mental Depression;Mentors;Mentorship;Methods;Minority;Modeling;older adult;older patient;Older Population;Outcome;Outcome Measure;Palliative Care;Patient Outcomes Assessments;patient population;Patients;Persons;Physical Function;Population;Population Research;Preparation;Probability;programs;Psychometrics;Publications;Quality of life;Race;racial difference;Research;Research Methodology;Research Personnel;Resources;Respondent;response;Risk Factors;satisfaction;Services;Site;Societies;Spanish;Spanish/English;Stress;Surveys;Symptom Burden;Techniques;Testing;theories;Training;Translations;Universities;web site;Work

PROJECT_TITLE: Measurement, Methods and Analyses (RC-MMA)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Alzheimer’s Disease (AD) is the most common type of dementia, causing a neurodegenerative cascade from neuronal synapse loss to eventual memory loss, yet there is currently no effective preventative treatment. This proposal will investigate mechanisms underlying prodromal AD cellular dysfunction, and whether restoration of function can prevent further pathology. Ultimately, this proposal aims to create an easily translatable disease therapy to intervene at an early phase in the progression of AD.

PI_NAMEs: GOETTEMOELLER, ANNIE M (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Acceleration;Action Potentials;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;American;Biophysical Process;biophysical properties;Biophysics;cell type;Cells;cerebral atrophy;Data;Dementia;designer receptors exclusively activated by designer drugs;Disease;disease model;early detection biomarkers;educational atmosphere;Electrophysiology (science);Enhancers;entorhinal cortex;excitatory neuron;excitotoxicity;Faculty;familial Alzheimer disease;Family;Frequencies;Functional disorder;Gene Expression;gene therapy;gene-targeted therapy;Genetic;hippocampal pyramidal neuron;Human;Image;in vivo;Interneurons;Intervention;Knock-in Mouse;Knowledge;Label;Laboratory Finding;Literature;Manuals;Measures;member;Memory Loss;Methods;Modeling;Molecular;Morphology;mouse model;mRNA Expression;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;Neurosciences;novel;novel diagnostics;novel therapeutics;overexpression;Parvalbumins;patch clamp;Patch-Clamp Techniques;Pathologic;Pathology;Pattern;Phase;Phenotype;prevent;Prevention;Preventive treatment;Process;prodromal Alzheimer's disease;programs;Reporting;Research;restoration;SCN1A protein;Senile Plaques;Somatosensory Cortex;Sorbus;Synapses;tau Proteins;Therapeutic;therapeutically effective;Time;two photon microscopy;two-photon;Universities;Vertebral column;Viral;voltage gated channel;Work

PROJECT_TITLE: Mechanism and restoration of altered firing in interneurons during early phase Alzheimer's Disease


NIH_SPENDING_CATS: Asthma;Climate-Related Exposures and Conditions;Clinical Research;Lung;Pediatric

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO RIO PIEDRAS

ORG_STATE: PR

PHR: Project Narrative This project will assist in the education and training of Puerto Rican high school students through the teaching of science, technology, engineering and mathematics (STEM) practices to develop them as a competitive future knowledge-based society. The project will create and foster the interest of STEM participants through research and hands-on experiences aimed to rise asthma awareness among Puerto Ricans.

PI_NAMEs: QUESADA, ORESTES  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Air;air monitoring;air sampling;Area;Asthma;Awareness;Biology;career;Chemistry;Climate;college;Communities;Community Health;Competence;computer science;COVID-19 pandemic;Creativeness;Data;Data Analyses;Development;digital tool;Discipline;Disease Outbreaks;Disparity;Education;Educational Curriculum;Educational process of instructing;Educational Status;Educational workshop;Engineering;Environment;Environmental Risk Factor;experience;Exposure to;Fostering;Future;Future Teacher;Geographic Locations;Goals;hands on research;Health;high school;High School Faculty;High School Student;Hurricane;Hypersensitivity;Imagination;Immersion;improved;innovation;interest;International;Knowledge;Labor Forces;Laboratory Research;Learning;Link;Location;mathematical sciences;microorganism;Molecular;Motivation;Participant;Personal Satisfaction;Physics;Preparation;Privatization;Process;programs;Puerto Rican;Puerto Rico;Research;Research Activity;Research Project Grants;Research Training;resource guides;response;Risk Factors;Role;Schools;Science;Science, Technology, Engineering and Mathematics;skills;social implication;Societies;STEM career;STEM field;student participation;Students;teacher;Teacher Professional Development;Time;Training;Training and Education;Training Programs;transmission process;twelfth grade;undergraduate student;Universities;University resources;Visit;web page;web site

PROJECT_TITLE: University of Puerto Rico STEM Asthma Awareness Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]