NIH_SPENDING_CATS: Aging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MANGIONE, CAROL M (contact)

PROJECT_TERMS: Address;African American population;Aging;Annual Reports;Area;Award;California;career;Collaborations;Communities;Community Actions;Country;Dedications;Disabled Persons;distinguished professor;Elderly;Elements;Endowment;Ensure;Ethnic Population;Faculty;Funding;Geriatrics;Goals;Group Meetings;Health;health disparity;health inequalities;Health Policy;Health Services Research;improve minority health;improved;innovation;Institution;Institutional Review Boards;interest;Internal Medicine;Intervention;K-Series Research Career Programs;Latino;Leadership;Medicine;meetings;member;Mentors;Minority;Minority Groups;Mission;multidisciplinary;Native Hawaiian or Other Pacific Islander;older adult;Older Population;Outcome;Performance;Personal Satisfaction;Pilot Projects;professor;Program Development;programs;Public Health;racial population;Recommendation;recruit;Reduce health disparities;Reporting;Research;Research Personnel;Running;Schedule;Science;Scientist;Site;success;Talents;Teacher Professional Development;Training;United States National Institutes of Health;Woman

PROJECT_TITLE: CHIME Leadership and Administrative Core


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PI_NAMEs: HAYS, RONALD DALE (contact)

PROJECT_TERMS: Address;Affect;Aging;aging population;Agreement;analytical method;Area;Behavior Therapy;Behavioral;biodemography;California;Cataloging;Centers for Population Health;Clinical Sciences;cognitive interview;Collaborations;Communities;Community Actions;community based participatory approach;Data;Data Analyses;Data Collection;data management;design;Development;Disadvantaged;education research;Educational Curriculum;Elderly;Elements;Epidemiology;ethnic diversity;Evaluation;experience;Exposure to;Faculty;Focus Groups;Funding;Goals;graduate school;Group Interviews;Health;health disparity;health inequalities;Hispanic;Hispanic-serving Institution;implementation science;improve minority health;improved;Individual;Interdisciplinary Study;International;Intervention;Investigation;Knowledge;Latino;Leadership;Location;low socioeconomic status;Measurement;Measures;Methodology;Methods;middle age;Minority;Minority Groups;minority health disparity;Mission;Modification;multidisciplinary;older adult;Older Population;Outcome;Pathway Analysis;Personal Satisfaction;Pilot Projects;Play;Policies;Policy Analysis;Population;population health;Population Heterogeneity;Population Research;Positioning Attribute;racial diversity;recruit;Research;research and development;Resources;Role;Science;Scientist;secondary analysis;social;System;tool;Training;training opportunity;Translational Research;Work

PROJECT_TITLE: CHIME Analysis Core (AnC)


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: PISCATAWAY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative The blood-brain barrier is critical for proper neuronal function, but is also a major obstacle for drug delivery to the brain. This proposal aims to uncover the role of a newly-discovered neural signal involved in the development and function of the vertebrate blood-brain barrier using both zebrafish and mouse model systems. The proposed experiments will also generate a new in vivo screening platform for blood-brain barrier function and identify novel small molecules that regulate barrier permeability, with the expectation that this will lead to better access for therapeutic treatments into the brain.

PI_NAMEs: O'BROWN, NATASHA  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: 4D Imaging;Address;Alzheimer's Disease;Area;Basic Science;Behavior;behavior change;Behavioral;Behavioral Assay;behavioral response;Binding;Biological Assay;Biological Models;Biology;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain cell;brain endothelial cell;career;Cell Physiology;Cell Transplantation;cell type;Cells;Cellular biology;Central Nervous System;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Confocal Microscopy;Defect;Development;Developmental Biology;developmental genetics;Dimensions;Drug Delivery Systems;Drug Screening;Embryo;Endothelial Cells;Environment;Exclusion;Exhibits;expectation;experimental study;Extravasation;Faculty;Fishes;Foundations;Future;Genes;Genetic;Genetic Markers;Genomics;Goals;high resolution imaging;Homeostasis;Human;Image;Image Analysis;in vivo;innovation;insight;Knock-out;Laboratories;Larva;Leadership;Learning;Maintenance;Malignant neoplasm of brain;Maps;Measures;Mediator;medical schools;Mentors;Mesoderm;Midbrain structure;Missense Mutation;Molecular;Molecular Biology;mouse model;Mus;Mutagenesis;mutant;Nervous System Disorder;Neural Crest;Neurodegenerative Disorders;Neurons;Neurophysiology - biologic function;neurotransmission;neurovascular;neurovascular unit;new therapeutic target;novel;novel therapeutics;oligodendrocyte progenitor;Parkinson Disease;Pericytes;Permeability;Pharmaceutical Preparations;Phenotype;Physiology;Population;Positioning Attribute;precursor cell;Property;Prosencephalon;Proteoglycan;quantitative imaging;reflectance confocal microscopy;Regulation;Reporter;Research;Resolution;response;Role;screening;seal;Signal Transduction;skills;small molecule;spatiotemporal;System;Techniques;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;Tracer;Training;transcriptome sequencing;Transgenic Organisms;Vascular Endothelial Cell;Vertebrates;Work;Zebrafish;zebrafish development

PROJECT_TITLE: The Role of Neurovascular Interactions in the Development and Regulation of the Blood-Brain Barrier

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: DEL PINO, HOMERO ERWIN (contact)

PROJECT_TERMS: Acceleration;Address;Age;Aging;Anticoagulant therapy;Anticoagulation;Area;Asian Americans;Atrial Fibrillation;Award;Behavioral;Behavioral Research;Biological;California;career;career development;Classification;Clinical;Clinical Research;clinical translation;Collaborations;Communities;Data;Dedications;Dementia;design;Discipline;Doctor of Philosophy;Education;education planning;education research;Elderly;ethnic disparity;ethnic health disparity;ethnic minority;Ethnic Origin;Exposure to;Faculty;faculty support;Fostering;frailty;Funding;Future;Geriatrics;Goals;Health;Health and Retirement Study;health data;Health Disparities Research;health disparity;health equity;health inequalities;Health Professional;Health Services Research;Healthcare;Hip Fractures;improve minority health;improved;Individual;instructor;interest;Internal Medicine;Intervention;Lead;Leadership;learning community;Life Cycle Stages;Link;Medical;Medical Sociology;Medicine;meetings;Mentors;Mentorship;mid-career faculty;Minority;Mission;Monitor;multiple chronic conditions;older adult;Older Population;Oral;Pacific Islander;Peer Review;Personal Satisfaction;Physiological;Pilot Projects;Population;Process;professor;programs;Progress Reports;Psychological Factors;Publications;Publishing;Race;racial difference;racial disparity;racial health disparity;racial minority;recruit;Request for Applications;Research;Research Methodology;Research Personnel;Research Support;Research Training;Resources;Science;science teacher;Scientist;sex;social;social culture;social factors;Social Sciences;socioeconomics;Standardization;Subgroup;success;supportive environment;Talents;therapy development;Training;Training Support;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Veterans;Warfarin;Work

PROJECT_TITLE: CHIME Research Education Component (REC)


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric - AIDS;Prevention;Telehealth;Women's Health Research

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Although pre-exposure prophylaxis (PrEP) is highly effective in preventing HIV infection, rates of initiation and adherence are low and discontinuation rates are high in young transgender women (TGW) in Thailand, a high-risk population facing complex barriers to HIV prevention (e.g., stigma, substance use). This project will develop a mobile, technology-delivered intervention program designed to help young (ages 18-29) HIV- negative TGW in Thailand start and remain on PrEP to prevent HIV infection. This study has potential to pave the way to the successful scale-up of PrEP implementation among TGW in Thailand.

PI_NAMEs: MACDONELL, KAREN ;PHANUPHAK, NITTAYA ;WANG, BO  (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adherence;Adult;Age;aged;AIDS prevention;Asia;Awareness;Biological Markers;Clinic;Clinical;community advisory board;Complex;Counseling;Country;culturally appropriate intervention;design;Development;Disproportionately impacts women;Drug usage;effective intervention;efficacy trial;emerging adult;emerging adulthood;Employment;Epidemic;Face;feasibility research;Gender;Gender Identity;group intervention;Health;Health Personnel;Health system;High Prevalence;high risk behavior;high risk population;HIV;HIV Infections;HIV Seronegativity;HIV Seroprevalence;HIV/STD;improved;Individual;innovation;Intervention;intervention program;intervention refinement;Interview;Joints;Mentors;Methods;mHealth;mhealth interventions;mobile application;mobile computing;Modeling;Monitor;Motivation;motivational enhancement therapy;multiphase optimization strategy;participant retention;Patient Recruitments;Pattern;Persons;Phase;Population;post intervention;pre-exposure prophylaxis;Prevalence;prevent;Prevention strategy;Process;Protocols documentation;Provider;Randomized;Recommendation;recruit;Research;response;Risk;Risk Taking;satisfaction;scale up;Self Management;sex;Sexual Health;side effect;social stigma;substance use;success;System;Technology;technology intervention;Testing;Text Messaging;Thailand;therapy design;Training Programs;transgender women;transmission process;Treatment Efficacy;United States Preventative Services Task Force;uptake;usability;vulnerable adolescent;webinar;Work

PROJECT_TITLE: Optimizing an mHealth intervention to improve uptake and adherence of the HIV pre-exposure prophylaxis (PrEP) in vulnerable adolescents and emerging adults


PI_NAMEs: SARKISIAN, CATHERINE A (contact)

PROJECT_TERMS: Academic support;Address;advocacy organizations;African American;Aging;American;Appointment;Area;Asian;behavioral and social science;bilingualism;biodemography;career;Cities;Clinical Sciences;cohort;Collaborations;Communities;community academic partnership;Community Actions;community engaged research;community engagement;Community Networks;community organizations;community partners;County;Data;design;education research;Elderly;Elements;Enrollment;ethnic diversity;Faculty;faculty community;Funding;Future;Genus Capra;Goals;Grant;Health;health disparity;health inequalities;Health Services;Hispanic;improve minority health;improved;Institution;Intervention;Knowledge;Korean American;Latinx;Leadership;Link;Los Angeles;Manuscripts;member;Mentors;Mentorship;Minority;minority health disparity;Minority Recruitment;model development;next generation;older adult;Older Population;Pacific Islander;Personal Satisfaction;Pilot Projects;Play;population health;Productivity;Public Health;recruit;Reduce health disparities;Research;Research Project Grants;Research Subjects;Resources;Role;Scientist;Services;skills;Structure;Students;Subgroup;Techniques;therapy development;Time;Training;Translational Research;undergraduate student;United States National Institutes of Health;Universities;Vietnamese;Vision;Work

PROJECT_TITLE: CHIME Community Liaison and Recruitment Core (CLRC)


ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Several serious inherited metabolic disorders affect lysine degradation, but there is little knowledge on the regulation of this catabolic pathway. The investigators have identified a novel mechanism controlling lysine degradation that will be further studied as a potential new target for the treatment of glutaric aciduria type 1.

PI_NAMEs: DEVITA, ROBERT J;HOUTEN, SANDER MICHEL (contact);LAZARUS, MICHAEL BLOCK

PROJECT_TERMS: Acids;Acute;Affect;Allosteric Regulation;Allosteric Site;alpha ketoglutarate;autosome;Binding;Biochemical;Biological;Caregivers;carnitine supplementation;Catabolism;Cell Line;cerebral atrophy;Clinical;clinically significant;Communities;Complex;Corpus striatum structure;Country;Defect;Development;Dietary Intervention;Disease;Disorder of neurometabolic regulation;Drug Design;Dystonia;Emergency Situation;Emergency treatment;Enzymatic Biochemistry;Enzyme Activation;enzyme activity;Enzymes;Functional disorder;Funding;glutaric acid;glutaric acidemia;Glutaryl-CoA dehydrogenase;Goals;health inequalities;Hereditary Disease;high throughput screening;Human;Hydroxylysine;Hyperlysinemias;Immunoprecipitation;improved;Inherited;inhibitor;insight;Intervention;Kinetics;Knowledge;Learning;Libraries;Lysine;Lysine Degradation Pathway;Macrocephaly;Measurement;Medical;Metabolic Diseases;Modality;Modeling;Molecular Conformation;mouse model;Neonatal Screening;Nervous System Disorder;neurotoxic;novel;novel therapeutic intervention;novel therapeutics;Outcome;Oxidoreductase;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Chemistry;pharmacologic;pharmacophore;prevent;Prevention;Proteins;Proteomics;Rare Diseases;Recommendation;Regulation;Research Personnel;Role;screening;screening panel;screening program;small molecule;small molecule inhibitor;social determinants;structural biology;Structure;Structure-Activity Relationship;Therapeutic;therapeutic development;Tryptophan;X-Ray Crystallography

PROJECT_TITLE: Allosteric regulation of lysine degradation as a novel pathophysiological mechanism in glutaric aciduria type 1

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Multiple system atrophy (MSA) is a fatal movement disorder caused by the misfolding and aggregation of the protein α-synuclein. Our research seeks to use gene therapy in a novel therapeutic approach to disrupt protein misfolding for the treatment of MSA and other neurodegenerative disorders.

PI_NAMEs: WOERMAN, AMANDA L. (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Adopted;alpha synuclein;Binding;Biological Models;Brain;Cell Line;Cells;Central Nervous System;clinical candidate;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cryoelectron Microscopy;Cultured Cells;Dependovirus;Disease;experimental study;FYN gene;gene therapy;gene-editing approach;Genes;Goals;Greek;Human;In Vitro;in vivo;innovation;Kinetics;knock-down;Lipid Binding;loss of function;Measures;Mediating;Membrane;Modeling;Molecular Conformation;Movement Disorders;Multiple System Atrophy;Mus;Mutation;Neurodegenerative Disorders;Neurons;novel;novel therapeutic intervention;Parkinson Disease;Pathogenicity;Patients;Point Mutation;Positioning Attribute;prevent;prime editing;Prion Diseases;prion-like;Prions;Process;protein aggregation;protein misfolding;Proteins;Research;Role;Sampling;Seminal;SNAP receptor;Sodium Chloride;Structure;Terminal Disease;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Transgenic Mice;Transgenic Organisms;transmission blocking;transmission process;treatment strategy;Work

PROJECT_TITLE: A Novel Gene Therapy Approach to Prevent Alpha-synuclein Misfolding in Multiple System Atrophy

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Digestive Diseases;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: Raleigh

ORG_NAME: GLYCAN THERAPEUTICS CORPORATION

ORG_STATE: NC

PHR: Project Narrative Heparan sulfate is a sulfated polysaccharide displaying a wide range of biological functions. In this project, Glycan Therapeutics plans to examine the potency and efficacy to protect againsr acetaminophen-induced acute liver failure using heparan sulfate oligosaccharides. The heparan sulfate will achieve the hepatoprotection by inhibiting excessive inflammatory responses from the host. The success of the project will provide a new therapeutic to treat drug-induced liver failure.

PI_NAMEs: WANG, ZHANGJIE  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Acetaminophen;acetaminophen overdose;Acute;Acute Liver Failure;Address;Adverse effects;American;Anti-Inflammatory Agents;Antidotes;Award;Biological Assay;Biological Process;chemical synthesis;Chemicals;Clinical;clinical trial recruitment;Clinical Trials Design;commercialization;comparative;comparative efficacy;Complex Mixtures;Consumption;cost;Cysteine;Cystine;design;Development;Disease;Dose;drug discovery;drug induced liver injury;Drug Kinetics;Fees;Formulation;Goals;Good Manufacturing Process;Heparin;heparin-induced thrombocytopenia;Heparitin Sulfate;hepatoprotective;Hepatotoxicity;HMGB1 gene;Hour;Immune response;immunogenicity;in vivo;Inflammation;Inflammatory;Inflammatory Response;Ingestion;Injury;Isotope Labeling;Label;lead candidate;Licensing;Liver Failure;liver injury;Liver Regeneration;liver transplantation;manufacture;Mediating;Methods;Miniature Swine;Modeling;mouse model;Natural Source;North Carolina;novel strategies;novel therapeutics;Oligosaccharides;Orphan Drugs;Patients;Pattern;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacology Study;Phase;phase 1 study;phase 2 study;Phase I Clinical Trials;Polysaccharides;pre-Investigational New Drug meeting;Preparation;Production;Protocols documentation;Publishing;Quality Control;Rattus;receptor for advanced glycation endproducts;Regimen;Reporting;Reproducibility;Route;Safety;Scheme;Sepsis;Small Business Innovation Research Grant;subcutaneous;success;sugar;Sulfate;systemic inflammatory response;Taxes;Therapeutic;Therapeutic Effect;therapeutic target;Toxic effect;Toxicokinetics;translational medicine;Translational Research;Trauma;Universities;waiver

PROJECT_TITLE: Development of heparan sulfate-based therapeutics to treat inflammatory diseases


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Rural Health;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE I am a nephrologist, physician-scientist and Professor at the University of Washington. I have a strong track record of NIDDK funding, leadership in education and mentorship. This award will provide key resources, training and professional development that will enhance my ability to serve as an effective mentor for post- doctoral trainees from backgrounds underrepresented in medicine and science.

PI_NAMEs: BANSAL, NISHA  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Academia;Acute Renal Failure with Renal Papillary Necrosis;Address;Administrative Supplement;Alaska;American Indians;Arrhythmia;Asian Americans;Award;Awareness;Cardiovascular Diseases;career;Chronic Kidney Failure;Clinical;Clinical Trials;Coupled;Development;Diagnosis;Dialysis procedure;Disease;Disparity;doctoral student;Education;education research;Educational Status;Endowment;epidemiology study;Ethnic Origin;Family;Fellowship;Foundations;Functional disorder;Funding;Future;Gender;Geography;Grant;Growth;health equity;Heart failure;hypertension treatment;Idaho;Individual;interest;Journals;Kidney Diseases;Kidney Failure;Kidney Transplantation;Leadership;Lesbian Gay Bisexual Transgender Queer;Measures;Medicine;Mentors;Mentorship;Mission;Montana;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;next generation;outreach program;Pacific Islander;patient oriented research;Patients;Persons;Philosophy;Physicians;post-doctoral training;Postdoctoral Fellow;Productivity;professor;programs;Publications;Publishing;Race;racial diversity;racism;Research;Research Infrastructure;Research Support;Resources;risk stratification;rural area;Scholarship;Science;Scientist;sex;Socioeconomic Status;Source;Students;success;Talents;Time;Training;training opportunity;Underrepresented Populations;United States National Institutes of Health;Universities;Washington;Woman;Work;Wyoming

PROJECT_TITLE: Mentored research in the intersection of kidney and cardiovascular disease


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Disability Research;Neurosciences

ORG_CITY: MILWAUKEE

ORG_DEPT: NEUROSURGERY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PUBLIC HEALTH RELEVANCE: Degenerative cervical myelopathy (DCM) is a major cause of spinal cord dysfunction and disability in older adults. This project will use novel spinal cord imaging and functional assessments to improve prediction of outcomes after surgery for DCM. This will enhance our knowledge of recovery of function and reduction of disability in DCM.

PI_NAMEs: VEDANTAM, ADITYA  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;axon injury;biomechanical test;Cervical;Clinical;Clinical assessments;clinical diagnosis;clinical examination;clinical phenotype;clinical translation;Clinical/Radiologic;cohort;Data;Decision Making;Demyelinations;Detection;Deterioration;Diagnosis;Diffusion Magnetic Resonance Imaging;disability;Dissociation;Equilibrium;Evaluation;Exhibits;experience;Functional disorder;functional gain;Future;Goals;Hand Strength;Histologic;Image;imaging approach;imaging biomarker;imaging modality;Imaging Techniques;Impairment;improved;individualized medicine;Injury;insight;instrumentation;Knowledge;Link;Magnetic Resonance Imaging;Measurement;Measures;metallicity;Metals;Methods;Monitor;Morphologic artifacts;Morphology;Motor;motor impairment;Nervous System Physiology;Neurologic;novel;older adult;Operative Surgical Procedures;Outcome;outcome prediction;Pathologic;Patients;Persons;postoperative recovery;Prognosis;prognostic;prognostication;public health relevance;Quality of life;quantitative imaging;Radiology Specialty;Recommendation;Recovery;Recovery of Function;Research;Residual state;Resolution;Sensorimotor functions;Sensory;Signal Transduction;Specificity;Spinal;Spinal Cord;spinal cord compression;Spinal cord damage;Spinal Cord Diseases;spinal cord imaging;Spinal cord injury;Stenosis;structural imaging;Structure;Structure-Activity Relationship;surgery outcome;Surgical Decompression;Symptoms;Techniques;Testing;tool;Upper Extremity;Walking

PROJECT_TITLE: Spinal cord structure-function relationships in degenerative cervical myelopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-D(90)M]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases

ORG_CITY: BELLEFONTE

ORG_NAME: ACTUATED MEDICAL, INC.

ORG_STATE: PA

PHR: Project Narrative: Relevance – Nearly 15% of the 7 million endoscopic polyp removal (polypectomy) procedures performed annually in the U.S., as a part of the regimen for colorectal cancer prevention, are considered complex. Many are large polyps (≥2cm). There is a lack of practical accessories that aid resection of these complex polyps, while also not interfering with the electrosurgical tools used in the working channel of the endoscope. The GripTract system is a disposable endoscopic accessory that enables physician-controlled tissue manipulation to facilitate complex polypectomy procedures like endoscopic submucosal dissection (ESD) – a technique that reduces the risks of reseeding potentially malignant lesions or producing incomplete resections. GripTract enables en bloc resection of these large polyps without occupying the working channel. This Phase IIB tests the GripTract system clinically in lower GI procedures. The project also expands the device models to use in upper GI procedures.

PI_NAMEs: MULVIHILL, MAUREEN L. (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: acute symptom;Adoption;Adult;Adverse event;adverse event risk;Agreement;American;Certification;Cessation of life;Childhood;Clinic;Clinical;Clinical Research;clinical research site;Colon;Colorectal Cancer;colorectal cancer prevention;commercialization;comparison control;Complex;Conduct Clinical Trials;cost;cost comparison;cost effective;Devices;Diagnosis;Diameter;Dissection;Distal;Effectiveness;Electrosurgery;Endoscopes;Endoscopy;Esophagus;Excision;experience;Family suidae;Fingers;flexibility;gastrointestinal;Gastrointestinal Endoscopy;Gastroscopes;Goals;grasp;Hand;Health Care Costs;healthcare burden;improved;in vivo;Incidence;innovation;Institutional Review Boards;Intestines;Japanese;Learning;Legal patent;Length;Lesion;Letters;Lower Gastrointestinal Tract;Malignant - descriptor;Malignant neoplasm of esophagus;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Manufacturer;Medical;Medical Device;meetings;minimally invasive;model development;Modeling;Morbidity - disease rate;Motion;Multi-site clinical study;operation;Operative Surgical Procedures;Outcome;Patients;payment;Perforation;Phase;Physicians;Polypectomy;Polyps;Pre-Clinical Model;preclinical study;Preparation;Procedures;programs;Public Health;Randomized;Recurrence;Recurrent tumor;Regimen;Resected;Residual state;Risk;Safety;Sales;Sessile Lesion;Site;Small Business Innovation Research Grant;Societies;Specific qualifier value;Speed;Stomach;Submucosa;Surgeon;Survival Rate;System;Techniques;technological innovation;Testing;Time;Tissues;tool;Traction;Training;tumor;Universities;verification and validation;Visualization;Woman

PROJECT_TITLE: Active Disposable Cap for Endoscope Tip Stabilization and Complete Visualization and Dissection of Serrated Sessile Polyps

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(10)]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: HOUSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: OVERALL – PROJECT NARRATIVE Improved understanding of the biology and heterogeneity of precursor lesions, including the interactions that these lesions harbor with the surrounding microenvironment, are a prerequisite for improving outcomes in pancreatic cancer, the third most common cause of cancer related deaths. The TriState Pancreatic Adenocarcinoma TBEL (Tri-PACT) Center brings together a collaborative group of investigators from three institutions who will use credentialed animal models and patient-derived materials to pursue three highly interdependent projects on basic and translational research in pancreatic cancer precursor lesions.

PI_NAMEs: MAITRA, ANIRBAN  (contact);PASCA DI MAGLIANO, MARINA

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: 3-Dimensional;Accounting;Animal Model;Architecture;Basic Science;Biology;Cancer Biology;Cancer Center;Cancer Etiology;cancer genomics;Cessation of life;Collaborations;Communication;Computational Biology;Credentialing;Cues;cytokine;Data Analyses;data analysis pipeline;data harmonization;Data Science;data sharing;Dependence;dimensional analysis;Disease;Disease Progression;Distant;Early Diagnosis;endoplasmic reticulum stress;Epithelium;Event;Excision;Fibroblasts;Genetic;Genetic Engineering;Genome;Goals;Heterogeneity;high dimensionality;Histologic;Histology;Human;Immune;improved;improved outcome;Individual;Institution;Interleukins;KRAS2 gene;Lesion;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mediator;member;Metabolic;Michigan;Mitochondria;Modeling;Molecular;molecular pathology;mortality;Mucinous Neoplasm;Mus;Mutation;Neoplasms;Oncology;Operative Surgical Procedures;Pancreas;Pancreatic Adenocarcinoma;Pancreatic cystic neoplasia;Pancreatic Ductal Adenocarcinoma;Pancreatic Intraepithelial Neoplasia;pancreatic neoplasm;Papillary;paracrine;Pathogenesis;Pathway interactions;Patients;Play;Pre-Clinical Model;premalignant;Process;programs;prototype;Quality Control;reconstruction;Research;Research Personnel;Resolution;Resource Sharing;response;Role;Seminal;Signal Transduction;Site;Specificity;Survival Rate;Testing;tool;Translational Research;translational study;tumor heterogeneity;tumor metabolism;tumor microenvironment;tumor progression;ubiquitin-protein ligase;United States;Universities;Validation

PROJECT_TITLE: Tumor Microenvironment Crosstalk Drives Early Lesions in Pancreatic Cancer


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PI_NAMEs: MAITRA, ANIRBAN  (contact)

PROJECT_TERMS: Adherence;Administrator;Advocacy;Advocate;Agreement;anti-cancer research;Awareness;Biometry;Budgets;Cancer Center;career;Collaborations;Communication;Communities;Consultations;Data;Data Coordinating Center;data integrity;Decision Making;Dedications;design;Doctor of Philosophy;Ensure;experience;Foundations;Funding;Goals;Grant;Human Resources;Hybrids;implementation facilitation;Information Dissemination;Institution;Lead;Leadership;Lesion;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;material transfer agreement;meetings;member;Michigan;Molecular Biology;molecular pathology;Monitor;Oncology;operation;Pancreas;Pancreatic Adenocarcinoma;pancreatic neoplasm;Patients;Persons;Preparation;Productivity;professor;programs;Progress Reports;Publications;quality assurance;Regulation;Reporting;Research;Research Activity;Research Personnel;Resource Sharing;Resources;Schedule;Science;Site;Site Visit;Transfer Agreement;tumor microenvironment;Universities;University of Texas M D Anderson Cancer Center;Update;virtual;web site;Wood material;working group

PROJECT_TITLE: TBEL Admin Core


PI_NAMEs: PASCA DI MAGLIANO, MARINA  (contact)

PROJECT_TERMS: advanced disease;cancer invasiveness;carcinogenesis;Cell Death;Cell Line;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;CXCL1 gene;cytokine;Data;Disease;disease natural history;DNA Binding Domain;Epithelial Cells;Epithelium;Family;Fibroblasts;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;homeodomain;Human;human tissue;IL6 gene;In Vitro;in vivo;Inflammatory;insight;KRAS oncogenesis;KRAS2 gene;Laboratories;Lead;Lesion;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;member;Metabolic;Modeling;Molecular;mouse model;Mucinous Neoplasm;Mus;mutant;Mutation;Natural History;Neoplasms;neoplastic cell;Nuclear;Organoids;Outcome;Pancreas;Pancreatic Ductal Adenocarcinoma;Pancreatic Intraepithelial Neoplasia;pancreatic neoplasm;Papillary;paracrine;Pathway interactions;Patients;Pattern;Population;premalignant;Process;receptor;response;Role;Signal Pathway;Signal Transduction;Testing;Tissue Microarray;tumor microenvironment;tumor-immune system interactions;Wood material

PROJECT_TITLE: TBEL Project 1


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

PROJECT_TERMS: 3-Dimensional;Abdomen;Accounting;Affect;Alleles;Biochemical;Biogenesis;cancer invasiveness;Cell Line;Cell Survival;clinic ready;clinical application;Collaborations;Colorectal Cancer;conditional knockout;Cyst;Cystic Lesion;Data;Dependence;Diagnosis;Drops;endoplasmic reticulum stress;Excision;Exhibits;Fibroblasts;Frequencies;functional loss;Genetic;genetic approach;Genetic Engineering;genetically modified cells;high risk;Histopathology;Human;Image;improved;In Vitro;in vitro Model;in vivo;Indolent;inhibitor;insight;Intervention;Knockout Mice;KRAS2 gene;Lesion;Location;Malignant neoplasm of pancreas;Malignant Neoplasms;Membrane Potentials;Metabolic Control;Metabolic Pathway;Metabolism;Mitochondria;mitochondrial metabolism;Modeling;Molecular;Molecular Biology Techniques;Morphology;mouse model;Mucinous Neoplasm;Mus;mutant;Mutate;Mutation;Nature;neoplastic;novel;Operative Surgical Procedures;Organ;Organelles;Organoids;Oxidative Phosphorylation;Pancreas;Pancreatic Cyst;Pancreatic cystic neoplasia;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Papillary;Pathogenesis;Patients;pharmacologic;Phase I Clinical Trials;Phosphorylation Inhibition;Pre-Clinical Model;Prevalence;Probability;Property;Proteins;proteostasis;Quality Control;reconstruction;Recording of previous events;Reporter;Reporting;Respiration;response;Role;Site;Solid;Testing;Tissues;tool;TP53 gene;tumor;tumor microenvironment;tumor progression;WNT Signaling Pathway;Wood material

PROJECT_TITLE: TBEL Project 2


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE A major obstacle in basic and translational neuroscience is the lack of animal models that have brain structure and function closely related to the human brain. Such models are critical to our understanding to higher brain function as well as developing therapeutics for brain disorders. The goal of this proposal is to establish an integrated experimental-computational platform to create the first comprehensive brain-wide mesoscale connectivity map in a non-human primate. This will help bridge the gap between brain-wide mesoscale connectivity data available for the mouse from a decade of mapping efforts using modern techniques and the absence of comparable data in humans and NHP.

PI_NAMEs: FENG, GUOPING  (contact);MITRA, PARTHA PRATIM;WANG, XIAO

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: 3-Dimensional;Address;Animal Behavior;Animal Model;Animals;Architecture;Atlases;Axon;Bar Codes;blood-brain barrier crossing;Brain;brain circuitry;Brain Diseases;brain volume;Callithrix;Callithrix jacchus jacchus;cell type;Cells;Collaborations;Collection;Communities;community engagement;comparative;Comparative Study;computational platform;Data;data acquisition;data analysis pipeline;Data Analytics;data dissemination;data management;data platform;Data Set;Detection;Discipline;Dorsal;frontal lobe;Genome;Genome Mappings;Goals;Human;imager;imaging modality;in situ sequencing;Individual;Injections;Institution;Label;Magnetic Resonance Imaging;Maps;Measures;Methods;Modeling;Modernization;Motor Cortex;Mus;neuronal cell body;Neurons;nonhuman primate;Organism;Phenotype;Primates;Process;prototype;reconstruction;Research;Resolution;Resources;RNA;Rodent;scale up;Site;Skeleton;Specificity;Spottings;Structure;System;Techniques;Therapeutic;Titrations;Tracer;transcriptomics;translational neuroscience;Validation;Viral;Visualization;web platform;web portal;web-based tool;whole genome

PROJECT_TITLE: BRAIN CONNECTS: Comprehensive regional projection map of marmoset with single axon and cell type resolution


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Prevention;Rare Diseases

PI_NAMEs: WOOD, LAURA DELONG (contact)

PROJECT_TERMS: 3-Dimensional;Automobile Driving;Biological;Biological Models;Cancer Etiology;cancer invasiveness;cancer prevention;Categories;Cell Density;Cells;Cessation of life;Clinical;Clonal Expansion;cohort;Computer Models;Cytometry;Data;Development;dimensional analysis;DNA Sequence Alteration;Early Diagnosis;Event;exome sequencing;experience;Foundations;Future;Gene Mutation;Genes;Genome;Genomics;High grade dysplasia;high risk;Human;human tissue;Image;Image Analysis;Immune;Immune response;immunogenicity;improved;In Vitro;in vivo Model;Indolent;innovation;insight;Intervention;Lesion;Malignant - descriptor;Malignant neoplasm of pancreas;Maps;Modeling;Molecular;Molecular Analysis;molecular scale;Morphology;Mus;Mutation;Myeloid Cells;neoantigens;neoplastic cell;non-genetic;novel;novel strategies;Pancreas;Pancreatic Intraepithelial Neoplasia;pancreatic neoplasm;Pathologic;potential biomarker;premalignant;Premalignant Neoplasm;Prevention approach;Publishing;Qualifying;reconstruction;Recording of previous events;response;Role;Sampling;Somatic Mutation;Specificity;Stromal Cells;synergism;T cell clonality;T cell receptor repertoire sequencing;Testing;Tissue Model;Tissue Sample;Tissues;tumor;tumor microenvironment;tumor progression;United States;Validation

PROJECT_TITLE: TBEL Project 3


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Digestive Diseases;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Rare Diseases

PI_NAMEs: FERTIG, ELANA  (contact)

PROJECT_TERMS: 3-Dimensional;algorithm development;Algorithms;analysis pipeline;Animal Model;anti-cancer research;Atlases;Automobile Driving;Biological;Biological Models;Biology;Cancer Biology;cancer cell;cancer initiation;cancer invasiveness;cancer type;cell behavior;Cells;Clinical;Coculture Techniques;Collaborations;Computer Analysis;Computer software;computerized tools;Computing Methodologies;computing resources;Data;Data Analyses;Data Coordinating Center;data harmonization;data integration;data platform;Data Science;Data Set;data sharing;data standards;data submission;data wrangling;design;Development;Disease;Ensure;Evolution;exome sequencing;experience;Experimental Designs;experimental study;Fee-for-Service Plans;flexibility;Gene Expression;Generations;Genetic Heterogeneity;Genetic Transcription;genomic data;Genomics;Goals;Heterogeneity;high dimensionality;high throughput analysis;Human;Imaging technology;Immune;improved;interoperability;Lead;Lesion;Machine Learning;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;meetings;Meta-Analysis;method development;Methods;Modeling;Molecular;Mucinous Neoplasm;multiple omics;novel;novel imaging technology;novel therapeutic intervention;Oncogenic;Oncology;Organoids;Outcome;Pancreas;Pancreatic Adenocarcinoma;Pancreatic Intraepithelial Neoplasia;Papillary;Pre-Clinical Model;premalignant;Premalignant Cell;Process;programs;Proteomics;Regulation;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Sampling;Scientist;single cell technology;Standardization;Stromal Cells;synergism;T cell receptor repertoire sequencing;Techniques;Technology;technology development;Three-Dimensional Imaging;tool;transcriptomics;transfer learning;tumor;tumor initiation;tumor microenvironment;Validation

PROJECT_TITLE: Multiscale Computational Oncology Research Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) has no effective disease-modifying therapeutics. This proposed research aims to (1) demonstrate that pharmacological inhibition of G9a/GLP can provide a novel and effective therapeutic strategy for the treatment of AD, and (2) optimize small-molecule G9a/GLP inhibitors into a drug candidate . Thus, the proposed research is directly relevant to public health.

PI_NAMEs: JIN, JIAN  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: absorption;Affinity;Alzheimer's Disease;Assessment tool;Behavior;Behavioral;Binding;Biochemical;Biological Assay;Biological Availability;Biophysics;Brain;Cells;Chemicals;ChIP-seq;Clinic;Cognitive;Communities;Complex;Dementia;design;Disease;drug candidate;Drug Kinetics;drug metabolism;Excretory function;Functional disorder;Gene Expression;gene repression;Genes;Genetic Transcription;Goals;Histone H3;histone methylation;improved;In Vitro;in vivo;in vivo Model;inhibitor;Lead;Link;Lysine;Metabolism;Methyltransferase;mouse model;Mus;novel;novel therapeutic intervention;Oral;Penetration;pharmacologic;Post-Translational Protein Processing;Property;Public Health;Research;Research Personnel;small molecule;small molecule inhibitor;Structure;Synapses;synaptic function;Testing;Therapeutic;therapeutically effective;tool;transcriptome sequencing;Translating;treatment strategy

PROJECT_TITLE: Novel Inhibitors of Lysine Methyltransferases G9a and GLP for the Treatment of Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(02)M]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project N arrative Dysregulation of gene expression driven by aberrant kinases can cause many diseases. The CDK8 complex, which consists of 4 transcription Mediator proteins, was found mutated in human diseases such as neurodevelopmental disorders and cancers. In this project, we will investigate the structure and function of the CDK8 complex, which is expected to provide crucial clues for the development of new strategies for disease treatment.

PI_NAMEs: TSAI, KUANG-LEI  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Affect;Antineoplastic Agents;Architecture;Binding;Biochemical;Cardiovascular Diseases;Colorectal Cancer;Complex;Cryoelectron Microscopy;Data;Development;Disease;drug development;Eukaryota;Foundations;Functional disorder;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genome;Goals;Human;human disease;inhibitor;insight;Investigation;kinase inhibitor;Knowledge;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mediator;Molecular;Mutate;Mutation;Neurodevelopmental Disorder;next generation sequencing;novel;novel therapeutics;Nucleic Acid Binding;Nucleic Acids;Oncoproteins;particle;Pathogenicity;Phosphorylation;Phosphotransferases;Polymerase;Property;Proteins;Recurrence;Regulation;Research;Resolution;RNA Polymerase II;Role;Signal Transduction;Structure;transcription factor;Transcriptional Regulation;tumor;Yeasts

PROJECT_TITLE: Structural insights into the Argonaute-containing CDK8 complex

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Teenage Pregnancy;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Latina adolescents in the United States are at higher risk of HIV/AIDS/sexually-transmitted infections and related health outcomes (e.g. mental health disorders, intimate partner violence) than their White counterparts. IMARA (Informed, Motivated, Aware, and Responsible Adolescents and Adults)—an evidence-based sexual health intervention for African American mother-daughter dyads—shows promise as a tool for addressing these health disparities, but the program’s potential benefits have yet to be assessed among Latinas. Drawing on an implementation science approach and in partnership with three community- based organizations in Chicago, this K99/R00 proposal will adapt IMARA to a Latina audience and pilot test an optimization trial using the multiphase optimization strategy (MOST), with the long-term goal of positively impacting the sexual health outcomes of Latina adolescents.

PI_NAMEs: MERRILL, KATHERINE GANNETT (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: 18 year old;Acceleration;Acculturation;Address;Adolescent;adolescent health;adolescent health outcomes;adolescent sexual behavior;Adult;adverse outcome;Affect;African American;African American population;Award;Awareness;Behavior Therapy;behavioral outcome;Biological;career;Chicago;Chlamydia;community advisory board;community based participatory research;community organizations;comparison control;Competence;contextual factors;Control Groups;Data Collection;Daughter;design;Development;driving force;Educational workshop;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;emotion regulation;Ethnic Origin;evidence base;Evidence based intervention;Evidence based program;experience;experimental study;Faculty;Family;Feedback;Female Adolescents;Focus Groups;General Population;girls;Goals;Gonorrhea;Grant;Health;health disparity;Health Promotion;high risk;high risk sexual behavior;HIV/AIDS;Home environment;implementation intervention;implementation science;Incidence;Individual;Infection;innovation;interest;Intervention;intervention mapping;intimate partner violence;Knowledge;Language;Latina;Latina Population;Learning;Link;Literature;Measures;Mediator;meetings;Mental Depression;Mental disorders;Mental Health;Mentors;Mentorship;Methodology;Methods;Mothers;multiphase optimization strategy;Outcome;Parents;peer;Phase;pilot test;Population Heterogeneity;Positioning Attribute;Pregnancy in Adolescence;Preparation;primary outcome;Process;programs;Publishing;Randomized, Controlled Trials;Religion;reproductive health intervention;Research;Research Design;Research Personnel;Risk;Running;scale up;Scientist;secondary outcome;sexual and reproductive health;Sexual Health;sexual health intervention;Sexually Transmitted Diseases;Shapes;South African;Spanish;substance use;symposium;Syphilis;tenure track;Testing;theories;tool;Training;Translating;Trichomonas;United States;Youth

PROJECT_TITLE: Evidence-based sexual and reproductive health intervention using a multiphase optimization strategy


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: 8. PROJECT NARRATIVE Digital breast tomosynthesis (DBT) is a technology that improves breast cancer screening accuracy over classic mammography but its large number of images means that it takes more time to read. We will investigate a series of interventions that can improve the speed and/or accuracy of DBT cancer screening. What we learn will advance our fundamental understandingof visual search and will be useful in any setting where technology has produced more images than users have time to examine.

PI_NAMEs: WOLFE, JEREMY M (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: 3-Dimensional;Address;Area;Attention;Basic Science;Breast;Breast Cancer Detection;Bypass;calcification;clinical application;clinically significant;computer aided detection;Consumption;cost;COVID-19;Data;Data Collection;Decision Making;detection platform;digital;Digital Breast Tomosynthesis;Digital Mammography;effective intervention;experimental study;Eye;Eye Movements;Goals;High Prevalence;Hybrids;Image;improved;interest;Intervention;Learning;Lifting;Location;Low Prevalence;Malignant Neoplasms;Mammography;Measures;Medical Imaging;Methodology;Methods;novel strategies;oculomotor behavior;pandemic disease;Perception;Performance;preservation;Prevalence;programs;Protocols documentation;radiologist;Reader;Reading;Recommendation;Research;Scanning;screening;Screening for cancer;Series;Slice;Speed;Techniques;Technology;Testing;Time;tomography;translational potential;Triage;Uncertainty;virtual;Visual;visual search;visual tracking;Work

PROJECT_TITLE: Improving Perception in Digital Breast Tomography


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Primary Health Care

ORG_CITY: ROCHESTER

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Persons living with HIV/AIDS (PLWHA) are understudied and underserved with respect to both dental and mental health services, compared to the general population. The present study will examine factors associated with referrals of PLWHA to dental and mental health services: comorbidity prevalence; patient and staff perceptions of successful referral factors; and information to inform future motivation-based strategies and R01-level studies. This study may help inform improved referral to dental and mental health treatment, leading to decreased morbidity in this population.

PI_NAMEs: GAJENDRA, SANGEETA  (contact);MCINTOSH, SCOTT

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Address;Administrator;Affect;Appointment;Behavior;Behavioral;Biological;Biological Markers;Caring;Case Management;Case Manager;Climate;Clinic;Clinical Data;clinical examination;comorbidity;comparison group;Competence;Complex;Data;Dental;Dental Anxiety;Dental Care;Dental Health Services;Dental Insurance;Dentists;Development;Diagnosis;Diagnostic;Early Diagnosis;Early treatment;evidence base;Focus Groups;Foundations;Frequencies;Funding;Future;General Population;Grant;Health behavior;Health Care Costs;health disparity;Health Professional;health service use;Health Services Accessibility;Health Status;Healthcare;HIV;HIV/AIDS;Human Resources;Immune system;improved;indexing;Individual;individual patient;Inflammation;Informal Social Control;informant;innovation;Interleukin-6;Intervention;Interview;Measures;Mental disorders;Mental Health;Mental Health Services;Methods;Morbidity - disease rate;Motivation;motivational enhancement therapy;Mouth Diseases;Oral health;Oral Health Impact Profile;Outcome;Outcome Study;Participant;patient population;patient screening;Patients;Perception;Periodontal Diseases;Persons;Population;Prevalence;programs;Prospective Studies;Psyche structure;psychiatric comorbidity;Questionnaires;randomized, clinical trials;Recommendation;Role;Salivary;Sampling;screening;Self Administration;Self Determination;Self Management;service providers;social;success;Surveys;theories;tool;Transportation;Treatment outcome;Underserved Population;United States National Institutes of Health

PROJECT_TITLE: Addressing Dental and Psychiatric Comorbidities: Screening and Referrals of HIV/AIDS Patients


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Cardiovascular;Clinical Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Heart Disease;Hypertension;Natural Products;Prevention;Substance Misuse

ORG_CITY: EAST LANSING

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: PROJECT NARRATIVE The prevalence of cannabis use is increasing among United States adults with chronic medical conditions. Cannabis use may trigger acute cardiovascular complications, and this effect can be more pronounced among individuals at a heightened risk for cardiovascular disease. The goal of this proposal is to recruit a cohort of adult patients with early-stage high blood pressure (i.e., hypertension) and study the prospective association between cannabis use trajectories and cardiovascular health.

PI_NAMEs: ALSHAARAWY, OMAYMA O (contact)

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Acute;Adult;Affect;Anorexia;Anxiety;Area;Atherosclerosis;Blood;Blood Pressure;Blood specimen;Blood Vessels;Cannabidiol;Cannabinoids;Cannabis;Cannabis policy;Cannabis retail;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cause of Death;Chest Pain;childhood epilepsy;Chronic;Chronic Disease;Clinical;cohort;Collection;Communication;Consumption;cytokine;Data;Diagnosis;Diastolic blood pressure;Early Diagnosis;Enrollment;epidemiology study;Epilepsy;Event;Feasibility Studies;Fibrinogen;Free Radicals;Goals;Growth;Harm Reduction;Health;Health Status;health warning;HIV;Home;Homeostasis;Human;Hypertension;Immune;Immune response;Individual;Inflammation;Inflammatory;Ingestion;Inhalation;innovation;interest;Knowledge;Laboratories;Laboratory Study;Legal;Malignant Neoplasms;marijuana legalization;Marijuana Smoking;marijuana use;marijuana user;Marketing;Measurement;Measures;Medical;Medical Marijuana;Mental Depression;Michigan;Midwestern United States;Modeling;National Institute of Drug Abuse;Natural Remedy;Neuropathy;non-drug;normotensive;Oral Ingestion;Organ;Outcome;Pain;Patient Recruitments;Patients;Pattern;Pharmacology;physical conditioning;Physiological;Platelet aggregation;poor sleep;Population;Post-Traumatic Stress Disorders;Prevalence;primary care clinic;Production;Prospective cohort;Prospective Studies;Questionnaires;Recommendation;Recreation;recruit;Reporting;Research;research study;Risk;Route;Sleep Disorders;sleep quality;Smoking;sound;Stress;systemic inflammatory response;Tetrahydrocannabinol;Therapeutic;Time;United States;Urinalysis;Vasospasm;Work;Youth

PROJECT_TITLE: Cannabis use and cardiovascular health outcomes among patients with high blood pressure

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Human socioeconomic status is one of the strongest predictors of health and mortality, however little is known regarding the neurobiological mechanisms predisposing individuals of low social status to neuropsychiatric disorders such as alcohol use disorder. This proposal will uncover neuroimmune and circuit determinants underlying mouse social rank-dependent differences in escalated alcohol drinking following a social isolation challenge, a profound stressor with increasing human relevance. The findings will advance our conceptual framework for neuroimmune regulation of circuits underlying social stress-associated alcohol drinking and potentially identify specific neuroimmune targets to inform therapeutic intervention, to ultimately narrow health disparities in AUD.

PI_NAMEs: PATEL, REESHA  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Alcohol consumption;alcohol free;alcohol intervention;alcohol use disorder;Alcohols;Amygdaloid structure;Anxiety;Automobile Driving;Behavior;Behavioral;Brain;Brain region;brain shape;Calcium;cell type;Cells;Data;Development;Development Plans;Diet;Dissection;drinking;Electrophysiology (science);Emotions;experience;experimental study;Faculty;Fluorescence-Activated Cell Sorting;Genes;genetic manipulation;Health;health disparity;Human;Image;in vivo;Individual;Link;Macrophage;Measures;Medial;Mediating;Microglia;mortality;Motivation;Mus;neural;neuroadaptation;neurobiological mechanism;Neuroimmune;neuroinflammation;Neurons;neuropsychiatric disorder;nonhuman primate;Nucleus Accumbens;optogenetics;Outcome;Pathologic;Pattern;Peripheral;Pharmaceutical Preparations;Positioning Attribute;Predisposition;Prefrontal Cortex;prevent;programs;recruit;Regulation;Research;response;Risk Factors;Rodent;Role;Shapes;Signal Transduction;social;social determinants;Social Hierarchy;Social isolation;Social status;social stress;Socioeconomic Status;Stress;stressor;targeted treatment;Technology;tenure track;Testing;Therapeutic Intervention;Training;transcriptome sequencing;transcriptomics;virtual;Water

PROJECT_TITLE: Corticolimbic Neuroimmune Determinants of Social Stress-Associated Alcohol Drinking


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Nonalcoholic fatty liver disease (NAFLD) is one of the leading causes of liver disease in the US; however, much remains to be discovered regarding the genetic factors that contribute to its development. The proposed research will demonstrate that TMEM55B contributes to intracellular lipid accumulation and NAFLD in animal models. Together, these results will enhance our understanding of the molecular contributors to NAFLD, which may lead to precision medicine advancements in NAFLD screening and treatment.

PI_NAMEs: MEDINA, MARISA WONG (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Adult;Animal Model;Animals;Antisense Oligonucleotide Therapy;base;Biochemical;Cholesterol;Cirrhosis;Defect;Dependence;Development;Diet;Disease;Disease Progression;disorder risk;Dynein ATPase;Estrogen Receptors;Estrogens;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Fatty Liver;Female;Fibrosis;Fructose;Functional disorder;Genetic;Genetic Complementation Test;Gonadal Steroid Hormones;Hepatic;Hepatocyte;Histologic;Homeostasis;Impairment;In Vitro;in vivo;Inflammation;insight;Integral Membrane Protein;Intracellular Accumulation of Lipids;knock-down;Knockout Mice;Link;Lipid Mobilization;Lipids;Lipolysis;Liver;Liver diseases;LoxP-flanked allele;Lysosomes;Maintenance;male;Mediating;men;Mitochondria;Modeling;Molecular;Morphology;Motility;Motor;mouse model;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Nuclear;Onset of illness;oxidation;Oxidative Stress;Pathology;Peripheral;pharmacologic;Phosphoric Monoester Hydrolases;Play;Ploidies;Positioning Attribute;precision medicine;Premenopause;prevent;Process;Production;Research;Role;screening;Sex Chromosomes;Sex Differences;Sorting;targeted treatment;Testing;Therapeutic Intervention;trafficking;Triglycerides;Very low density lipoprotein;very low density lipoprotein triglyceride;western diet;Woman;women versus men

PROJECT_TITLE: TMEM55B as a molecular determinant of NAFLD

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project narrative  This proposed project will develop a plasma test that can supplement CT screening for precisely detecting lung cancer.

PI_NAMEs: JIANG, FENG  (contact);STASS, SANFORD A

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;Baltimore;Benign;Biological Markers;biomarker panel;biomarker validation;Blinded;Blood Plasma Volume;Cancer Detection;cancer diagnosis;Caring;Certification;Cessation of life;Clinic;Clinical;Clinical Laboratory Improvement Amendments;Clinical Research;cohort;Collaborations;Complement;Complex;computed tomography screening;cost;Data;design;Development;Diagnosis;Diagnostic Procedure;Diagnostic tests;effective therapy;Environment;Evaluation;follow-up;Future;geographically distant;Growth;Healthcare Systems;Institutional Review Boards;Laboratories;laboratory equipment;Laboratory Research;low dose computed tomography;lung cancer screening;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Maryland;Medical;Medicare;microRNA biomarkers;MicroRNAs;Morbidity - disease rate;mortality;multidisciplinary;new technology;next generation sequencing;Non-Small-Cell Lung Carcinoma;Performance;performance tests;Phase;Plasma;Population;predictive modeling;Preparation;Procedures;Process;prospective;Protocols documentation;Quality Control;Recommendation;Reflex action;Reproducibility;research clinical testing;Resources;Reverse Transcription;sample collection;Sampling;Scanning;Scientist;screening program;Secure;Smoker;smoking-related disease;Specificity;Specimen;success;System;Target Populations;Technology;Testing;Therapeutic procedure;Translating;United States Centers for Medicare and Medicaid Services;Universities;Variant

PROJECT_TITLE: Plasma biomarkers for lung cancer diagnosis


ADMINISTERING_IC: MH

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE The goal of this proposal is to understand the mental processes and brain systems that enable people to purposefully remove emotional thoughts from their minds. The project will utilize neuroimaging of the brain in conjunction with cutting-edge computational techniques taken from computer science to assess how well individuals can remove specific thoughts from mind. This work has important implications for psychiatric disorders in which the ability to remove specific negative, intrusive, or maladaptive thoughts is compromised.

PI_NAMEs: BANICH, MARIE T (contact);LEWIS-PEACOCK, JARROD A

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Address;Affect;Amygdaloid structure;Anxiety;associated symptom;Attention;base;Behavior;Brain;Brain imaging;Cognitive;cognitive control;Computational Technique;computer science;Control Groups;design;Effectiveness;Emotional;Excision;expectation;Feedback;Functional Magnetic Resonance Imaging;Goals;imaging approach;improved;indexing;Individual;Individual Differences;innovation;insight;Knowledge;Machine Learning;Measures;Mental Depression;Mental disorders;Mental Processes;Mind;Nature;neural;neural patterning;neurofeedback;neuroimaging;neuromechanism;novel;operation;Patient Self-Report;Pattern;Persons;Prefrontal Cortex;Process;Psyche structure;Psychopathology;Recording of previous events;Recurrence;Reporting;Research;Research Personnel;rumination;Scientist;Sensory;Series;Short-Term Memory;Stimulus;success;Symptoms;System;Techniques;Testing;Thinking;thought control;Time;Training;Update;Vehicle crash;Visual Cortex;weapons;Work

PROJECT_TITLE: Neural and Cognitive Mechanisms for Removing Emotional Information from Working Memory

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Depression;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This K99 Career Development Award seeks to provide the applicant training in perinatal women's mental health with a dyadic focus, perinatal maternal immune function, pregnancy morbidity and health disparities, and biostatistics under a Developmental Origins of Health and Disease (DOHaD) framework to support the applicant's transition to research independence. Through the training embedded in this award, the applicant will develop the skills and expertise necessary to build a translational research program that will examine pathways by which perinatal maternal health factors affect offspring brain and behavioral development and risk for neurodevelopmental disorders. This approach will ultimately identify mechanisms, markers, and modifiable risk factors relevant to both maternal mental health and child neurodevelopmental outcomes.

PI_NAMEs: SHUFFREY, LAUREN CHRISTINE (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Affect;Age Months;antepartum depression;Anxiety;Attention;Attentional deficit;Auditory;Award;Behavioral;Biological;Biological Assay;Biomedical Research;Biometry;Birth;Blood;Brain;Buffers;Child;Child Mental Health;Clinical Research;cohort;comorbidity;Data;Data Set;density;Development;Diagnosis;Disease;disparities in morbidity;Disproportionately impacts women;Electroencephalography;Emotional;ethnic minority population;Event-Related Potentials;experience;Exposure to;Funding;Future;Gestational Diabetes;Goals;Health;health disparity;immune function;indexing;Infant;Inflammation;Inflammatory;Interferon Type II;Interleukin-1 beta;Interleukin-6;Intervention;K-Series Research Career Programs;Knowledge;Kynurenine;maternal depression;Maternal Health;maternal risk;Measures;Medical Records;Memory;Mental Depression;Mental Health;Metabolic;Methodology;modifiable risk;neonatal brain;neural;neurobehavioral;Neurodevelopmental Disorder;Newborn Infant;offspring;Outcome;Pathway interactions;Perinatal;perinatal mental health;perinatal women;peripartum depression;Phase;Phenotype;Plasma;postnatal;Postpartum Depression;Postpartum Period;Pregnancy;prenatal;prenatal exposure;prospective;Proteins;psychosocial;racial minority population;Research;Risk;Risk Factors;Role;Serum;Shapes;skills;social;Stress;sustained attention;TNF gene;Toddler;Training;translational research program;Tryptophan;Underrepresented Populations;United States;Venipunctures;Visual;Woman

PROJECT_TITLE: Gestational Diabetes Mellitus, Perinatal Depression, and Offspring Neurodevelopmental Phenotype


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Sleep Research

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Short sleep duration is a highly prevalent behavior among young adults and has been strongly associated with obesity risk in observational and laboratory studies. This proposal aims to determine whether weight loss outcomes in lifestyle interventions can be improved by adding an intervention component to extend sleep duration in overweight young adults with habitual short sleep duration. This research has significant public health implications for preventing the development of obesity and cardiometabolic disease among young adults. .

PI_NAMEs: TASALI, ESRA  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Accelerometer;Address;Affect;Age;alertness;Behavior;behavior change;Behavioral;Biological;Biological Factors;Biological Markers;Blood Pressure;Body fat;Body mass index;Body Weight Changes;Body Weight decreased;Caloric Restriction;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Clinic;clinical application;Cognitive;Continuous Glucose Monitor;Counseling;Custom;Data;Data Display;Diet;dietary;Dietary intake;dietary restriction;doubly-labeled water;Drowsiness;Dual-Energy X-Ray Absorptiometry;Eating;Electrocardiogram;emotional eating;energy balance;Energy Intake;Energy Metabolism;Epidemiology;evidence base;executive function;Feedback;fitbit;Food;ghrelin;Glucose;Health;Heart Rate;Home;Hour;Hunger;Hyperphagia;improved;indexing;Indirect Calorimetry;insight;Intervention;Intervention Trial;Knowledge;Laboratories;laboratory experiment;Laboratory Study;Leptin;Life;Life Style;lifestyle intervention;Lipids;Maintenance;Measures;Methods;Monitor;Motivation;novel;novel strategies;Obesity;obesity development;obesity prevention;obesity risk;Observational Study;Outcome;Overweight;Participant;Phase;Physical activity;Physical assessment;Population Study;Prevalence;prevent;primary outcome;psychosocial;Psychosocial Factor;Public Health;Randomized;randomized, clinical trials;Regulation;Research;response;Rest;Roentgen Rays;secondary outcome;sedentary;Self Efficacy;Sleep;sleep behavior;Sleep Deprivation;sleep pattern;smartphone application;success;Technology;telecoaching;Time;total energy expenditure;Weight;weight loss intervention;weight loss program;wireless;Work;young adult

PROJECT_TITLE: Sleep Extension: A Novel Intervention for Weight Loss in Young Adults

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Project Narrative  This project aims to improve the treatment of severe destructive behavior exhibited by children with developmental disabilities by refining the critically important process of reinforcement schedule thinning. Reinforcement schedule thinning will be completed in fewer sessions when its starting point is informed by the results of a progressive interval assessment, and providing competing stimuli will further shorten this process by producing less destructive behavior when compared to a traditional treatment. These treatment gains will extend to a condition in which the reinforcer for destructive behavior remains unavailable for an extended period of time.

PI_NAMEs: GREER, BRIAN D. (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Acceleration;Affect;Aggressive behavior;Animals;Attention;autism spectrum disorder;Behavior;Behavior Disorders;Caregivers;Caring;Child;Clinical;Clinical Research;Clinical Services;Communication;Communities;comorbidity;Dangerousness;Developmental Disabilities;developmental disease;Educational process of instructing;effective therapy;Equation;Exhibits;Extinction;Family;Future;Home;improved;Institutionalization;Intellectual functioning disability;Intervention;Laboratory Research;Methods;Motivation;novel;Outcome;Patients;Pharmaceutical Preparations;Physical Restraint;Play;prevent;Process;process improvement;Psychological reinforcement;Quality of life;Randomized, Controlled Trials;Reinforcement Schedule;reinforcer;Relapse;Research;Resources;response;Risk;Role;Schedule;Self-Injurious Behavior;service delivery;Services;Severities;Signal Transduction;social integration;Social isolation;Source;Stimulus;Testing;theories;Thinness;Time;Training;Work

PROJECT_TITLE: Motivational Refinements for Facilitating Reinforcement Schedule Thinning

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Rare Diseases

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Myotonic dystrophy (DM) is the most common cause of adult onset muscular dystrophy and the second most common cause of muscular dystrophy overall. How the DM type 1 mutation specifically leads to muscle wasting at the molecular level is unknown. The goal of this proposal is to determine the role of CELF1 upregulation in muscle pathogenesis in combination with MBNL loss of function.

PI_NAMEs: COOPER, THOMAS A (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 3' Untranslated Regions;Adult;Affect;Alleles;Alternative Splicing;autosome;Blood specimen;Characteristics;Clinical;combinatorial;CUG repeat;Disease;Disease Progression;Embryo;Etiology;Exons;Family;Family member;Fetal Proteins;Foundations;Frequencies;gain of function;Genes;Genetic;Genetic Transcription;Goals;Histopathology;Human;In Vitro;in vivo;Individual;knock-down;Knock-out;Link;loss of function;LoxP-flanked allele;Messenger RNA;Modeling;Molecular;mortality;mouse model;mRNA Translation;Mus;Muscle;Muscular Atrophy;Muscular Dystrophies;mutant;Mutation;Myopathy;Myotonic Dystrophy;Myotonic dystrophy type 1;Natural regeneration;Newborn Infant;Nuclear;Nuclear RNA;Pathogenesis;Pathogenicity;Pathology;Pattern;Phenotype;Physiological;Play;postnatal development;Prevalence Study;Protein Isoforms;Proteins;Regulation;response;RNA;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;Severity of illness;Skeletal Muscle;skeletal muscle weakness;small hairpin RNA;System;targeted treatment;Tissues;Toxic effect;Transgenic Mice;Translations;United States;Up-Regulation;wasting;Work

PROJECT_TITLE: Mechanisms of Skeletal Muscle Pathogenesis in Myotonic Dystrophy Type 1

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: IRVINE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Cancer-related cognitive impairment (CRCI) or chemobrain is one of the major quality of life issue for cancer survivors thereby mechanism-based mitigating strategies are clearly needed. This proposal (in response to a chemobrain RFA, PAR-21-329) will evaluate the augmentation of brain derived neurotrophic factor (BDNF) as a viable strategy for improving CRCI through genetic and pharmacological strategies using in vivo pre-clinical models to ascertain the neuroprotective role of enhancing BDNF to ameliorate CRCI.

PI_NAMEs: ACHARYA, MUNJAL M;CHAN, ALEXANDRE  (contact)

PROGRAM_OFFICER_NAME: CLIFFORD, JOHN LEO

PROJECT_TERMS: Amygdaloid structure;Architecture;axon growth;behavior measurement;Blood;Brain;Brain Injuries;Brain-Derived Neurotrophic Factor;Breast Cancer Model;Breast Cancer survivor;Breast Cancer Treatment;Cancer Patient;Cancer Survivor;cancer therapy;cancer-related cognitive impairment;Cell Culture Techniques;Cell Maintenance;chemobrain;chemotherapy;Chemotherapy-Oncologic Procedure;Chronic;Clinical;Clinical Data;Clinical Research;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive task;Cyclophosphamide;Data;Dendrites;Disease;Distress;Doxorubicin;Drug Kinetics;Electrophysiology (science);enhancing factor;Ensure;Exposure to;Future;Genetic;Glutamates;high risk;Hippocampus;Human;Impaired cognition;Impairment;improved;in vivo;Link;Long-Term Potentiation;Malignant Breast Neoplasm;Measurement;Mediating;Modeling;mouse model;Mus;Nerve Degeneration;nerve stem cell;neural circuit;Neurobiology;neurogenesis;neuroinflammation;Neurons;neuroprotection;Oral;Pathologic;Patients;Performance;Pharmaceutical Preparations;pharmacologic;phase 1 study;Plasma;Play;pre-clinical;Pre-Clinical Model;preclinical study;Prefrontal Cortex;prevent;Quality of life;regenerative approach;repaired;response;Riluzole;Risk;Rodent;Rodent Model;Role;Safety;Series;Severities;side effect;Slice;stem cell proliferation;Survivors;Synapses;Testing;Therapeutic;Toxic effect

PROJECT_TITLE: Neurotrophic strategy to mitigate chemotherapy-related brain injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-K(55)R]


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Transplantation

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: APOL1 genetic risk variants, found almost exclusively in individuals of African ancestry, are associated with non-diabetic kidney disease in African Americans, explaining up to 70% of the excess risk for kidney disease seen in this population. Given that kidney transplantation is the preferred treatment for the individuals who progress to end stage kidney disease, knowledge about the impact of APOL1 risk variants on kidney transplant outcomes for both living donors who have the variants and the recipients who receive donor kidneys with the variants is essential. This knowledge will lead to better informed consent, improved organ allocation, and plausibly improved clinical outcomes for both donors and recipients.

PI_NAMEs: BIRDWELL, KELLY A (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Academic Medical Centers;academic program;Acceleration;Acute;Address;African American;African American population;African ancestry;AIDS-Associated Nephropathy;Albumins;Allografting;American;Antibodies;Apolipoproteins;Bacterial Infections;Biological;Biopsy;Black American;Blood;Chronic;Clinical;clinical center;Clinical Data;cohort;Communities;Consent;Cost Savings;Counseling;Creatinine;Data;digital pathology;Disadvantaged;Disparity;Disparity population;DNA;Donor Exclusions;Donor person;Economic Factors;Education;Eligibility Determination;End stage renal failure;Enrollment;Ensure;Environmental Risk Factor;ethnic difference;European;Evaluation;experience;Face;Failure;Focal and Segmental Glomerulosclerosis;follow-up;Foundations;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic Screening;Genotype;Geography;Goals;graft failure;Graft Survival;Health Care Costs;high risk;HLA Antigens;Hypertension;Immunosuppression;improved;Individual;Informed Consent;Kidney;kidney biopsy;Kidney Diseases;Kidney Failure;Kidney Transplantation;Knowledge;Lesion;Living Donors;living kidney donor;Longterm Follow-up;Measures;Medical;nephrogenesis;non-diabetic;novel;Organ;organ allocation;Organ Procurements;Outcome;Participant;Pattern;Phase;Phenotype;Policies;Population;post-transplant;Prevalence;primary outcome;programs;prospective;Proteinuria;Qualifying;Quality of life;racial difference;recruit;Recurrent disease;Registries;Renal function;Reporting;repository;Request for Applications;Research;response;Risk;risk variant;Role;Safety;secondary outcome;Serum;Site;Slide;social;targeted treatment;Time;transplant centers;Transplant Recipients;Transplantation;United Network for Organ Sharing;United States National Institutes of Health;Universities;Urine;Variant;Virus Diseases;Work

PROJECT_TITLE: Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Pediatric;Rare Diseases;Sickle Cell Disease

ORG_CITY: OWINGS MILLS

ORG_NAME: EMOCHA MOBILE HEALTH, INC.

PHR: Project Narrative/Public Health Relevance Statement: This research is highly relevant to public health as youth with sickle cell disease (SCD) are underserved and remain at high risk for adverse acute and long-term health outcomes. Hydroxyurea is the primary disease-modifying medication for these youth, but hydroxyurea non-adherence is common and a key reason for its limited impact in clinical practice. Relevant to the NHLBI’s goal to optimize therapeutic strategies for SCD, this proposal will answer the critical questions to conduct a successful efficacy trial of video directly observed therapy, a promising adherence-promoting intervention, to improve hydroxyurea adherence and outcomes among youth with SCD.

PI_NAMEs: CREARY, SUSAN ;SEIGUER, SEBASTIAN  (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Acute;Adherence;Admission activity;Adolescence;Adolescent;Affect;aged;American;arm;attentional control;Attenuated;Behavior;behavior change;behavioral outcome;Blinded;burden of illness;Businesses;care costs;Caregivers;Caring;Cellular Phone;Child;Childhood;Chronic;Chronically Ill;clinical practice;Clinical Trials;comorbidity;compliance behavior;cost;Data;data access;design;Directly Observed Therapy;Disease;effective therapy;Effectiveness;efficacy trial;electronic adherence monitoring;Electronic Mail;Electronics;Emergency department visit;experience;Feedback;financial incentive;Funding;Goals;Health;Health Care Costs;Hematological Disease;high risk;Hospitalization;hydroxyurea;improved;improved outcome;Inherited;Intervention;Intervention Studies;Life Cycle Stages;Measures;Methods;mhealth interventions;Monitor;Morbidity - disease rate;National Heart, Lung, and Blood Institute;Outcome;Participant;patient engagement;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Population;preference;Procedures;Public Health;public health relevance;Qualifying;Randomized;Randomized, Controlled Trials;Records;recruit;Research;Research Personnel;Sickle Cell Anemia;Site;System;Telephone;Testing;Therapeutic;Training;Translating;trial comparing;user-friendly;video delivery;young adult;Youth

PROJECT_TITLE: ADHERE (Applying Directly observed therapy to HydroxyurEa to Realize Effectiveness)


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Patient Safety;Precision Medicine;Prevention

ORG_CITY: Portland

ORG_NAME: LEGACY EMANUEL HOSPITAL AND HEALTH CENTER

ORG_STATE: OR

PHR: Project Narrative This project will provide important new information about the effect of different patterns and severities of visual field loss on quality of life. The primary goal is to develop new summary indices based on current clinical testing that predict the effects on different aspects of quality of life, individualized to the patient. These can be used as patient-centered outcomes for clinical trials, and to personalize treatment options and medical advice for an individual patient in clinical care.

PI_NAMEs: GARDINER, STUART  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Activities of Daily Living;Affect;Blindness;Caring;Cellular Phone;Central Scotomas;Clinic;Clinical;clinical care;Clinical Management;Clinical Trials;Consumption;Contrast Sensitivity;Custom;Data;Devices;Disease;Electronics;equilibration disorder;Equilibrium;experience;Eye;Fall prevention;fall risk;falls;functional loss;Glaucoma;Goals;Health;Hospitalization;hypertension treatment;Impairment;improved;indexing;Individual;individual patient;Light;Light Adaptations;Lighting;Location;Longitudinal Studies;Measurement;Measures;Medical;medication compliance;Motivation;National Eye Institute;novel;Ocular Hypertension;Older Population;Outcome Measure;Participant;Patient Care;patient oriented;Patient Outcomes Assessments;Patient Self-Report;Patient-Focused Outcomes;Patients;Pattern;Perimetry;Peripheral;personalized medicine;Persons;preventive intervention;prospective;Quality of life;Questionnaires;rate of change;Reporting;Research;research clinical testing;Risk;Scotoma;Severities;Severity of illness;Tablet Computer;Tablets;Testing;Time;Trabeculectomy;treatment adherence;Vision;Visit;Visual;Visual Fields;visual search;Visual System;Work;Writing

PROJECT_TITLE: Functional Testing and Quality of Life in Glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_NAME: CUNY GRADUATE SCH AND UNIV CTR

PHR: PROJECT NARRATIVE The global population of older adults with dementia is expected to increase to upwards of 132 million people by 2050, prompting the early identification of clinical presentations associated with increased risk for this disorder. The current project uses a novel, multifaceted approach to assess subjective cognition in Motoric Cognitive Risk Syndrome (MCR), an easily screened predementia condition that combines slow gait speed and subjective cognitive concerns, and predicts cerebrovascular-related risk in diverse older adult populations. This study will be the first to systematically characterize the nature and extent of subjective cognitive concerns in MCR, facilitating new screening tools with enhanced sensitivity for dementia in health disparity populations around the globe.

PI_NAMEs: NESTER, CAROLINE  (contact)

PROGRAM_OFFICER_NAME: HOMMER, REBECCA EVE

PROJECT_TERMS: Acceleration;accurate diagnosis;Address;advanced disease;Aging;aging population;Alzheimer's Disease;Biological Assay;Cellular Phone;cerebrovascular;Clinical;clinical care;clinically relevant;Cognition;Cognitive;cognitive ability;cognitive change;cognitive disability;cognitive function;cognitive testing;cohort;Collaborations;Communities;Complex;cost;Dementia;dementia risk;Detection;Development;Diagnosis;Diagnostic;diaries;disability;Disease;disorder risk;Early Diagnosis;Early identification;Enrollment;Evaluation;Foundations;functional decline;functional disability;Functional impairment;functional status;Future;Gait;Gait speed;geriatric depression;Goals;health disparity populations;Impaired cognition;Impairment;improved;Individual;innovation;Intervention;Knowledge;Learning;Longitudinal Studies;Measures;Memory;Methodology;Methods;mild cognitive impairment;mixed dementia;Modality;Monitor;Nature;Nerve Degeneration;Neuropsychology;novel;older adult;Older Population;Paper;Participant;Persons;Population;Populations at Risk;pre-clinical;Predictive Value;Preventive measure;programs;Public Health;Questionnaires;Reduce health disparities;Reporting;Research;Research Personnel;Research Training;Resources;response;Risk;Risk Factors;risk prediction;Role;Rural;Sampling;Scientist;screening;Screening procedure;Self Assessment;Severities;Syndrome;Techniques;Telephone Interviews;Testing;Training;Vascular Cognitive Impairment;Vascular Dementia;Vulnerable Populations;Work

PROJECT_TITLE: Subjective Cognition in Motoric Cognitive Risk Syndrome: Enhancing Cerebrovascular Risk Detection in Health Disparity Populations


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health;Prevention;Suicide

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Research on suicide has increased in recent years, but relatively little is known about health outcomes among the family and friends of individuals who die by suicide (i.e., “suicide loss survivors”). This study will use Danish national registry data to document the short- and long-term mental and physical health outcomes and comorbidities among suicide loss survivors over a 30-year period. We will determine if adverse outcomes are specific to suicide loss, or unexpected loss in general, and further examine how outcomes and comorbidities vary across relationship types (e.g., spouses versus children) and sex.

PI_NAMEs: GRADUS, JAIMIE L.;ROSELLINI, ANTHONY JOSEPH (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Accidents;Address;Adverse event;adverse outcome;Big Data;Caring;Cessation of life;Child;cohort;comorbidity;comparison group;Computerized Medical Record;cost efficient;Data;data registry;Data Sources;Denmark;design;Diagnostic;Disease;Distress;eHealth;emotional distress;Epidemiology;epidemiology study;Event;experience;Exposure to;Family;First Degree Relative;follow-up;Foundations;Friends;Funding;Future;General Population;Goals;Government;Health;Healthcare;Healthcare Systems;high risk;improved;Individual;Insurance;International Classification of Disease Codes;Intervention;Knowledge;Link;Literature;longitudinal design;Medical;Mental Health;Methods;National Institute of Mental Health;novel;Outcome;Pattern;Persons;physical conditioning;Policy Maker;Population;population based;prevent;Prevention;Psychiatric epidemiology;Public Health;Publishing;Records;Registries;Reporting;Research;Resources;Sample Size;Sampling;secondary analysis;Selection Bias;sex;social;sociodemographics;Source;Spouses;Subgroup;suicidal individual;suicidal morbidity;Suicide;Suicide prevention;Survivors;therapy design;Time;Trauma;traumatic stress;United States;United States Department of Veterans Affairs;unsupervised learning;Work

PROJECT_TITLE: Identifying the longitudinal outcomes of suicide loss in a population-based cohort

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Empirical data have not provided strong evidence that people consume alcohol in response to the experience of negative emotions in everyday life, despite theoretical predictions and evidence from cross-sectional and retrospective data to the contrary. The proposed study will employ a combination of innovative experimental and ecologically valid approaches to explore affect-motivated drinking as a decision that depends on the value assigned to alcohol relative to the value assigned to alternative substance-free reinforcers (e.g., consuming appetizing food) in emotional situations. Findings will improve our understanding of whether, when, how, and for whom alcohol use is reinforcing in everyday life, which will inform future prevention and treatment efforts attempting to help people reduce their problematic alcohol use.

PI_NAMEs: DORA, JONAS  (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Addictive Behavior;Affect;Affective;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol reinforcement;alcohol research;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Award;Behavior;Behavioral Model;Binge Eating;career;Cognitive Science;Computer Models;Consumption;coping;Data;Decision Making;Development;Diffusion;Doctor of Philosophy;drinking;drinking behavior;Ecological momentary assessment;Educational workshop;emotion regulation;Emotional;emotional experience;Emotions;Empirical Research;Environment;experience;experimental study;Food;Foundations;Future;Goals;Human;improved;Individual;innovation;insight;Institution;Intoxication;Laboratories;laboratory experiment;Learning;Life;Maps;Mentors;Meta-Analysis;Methods;Modeling;Moods;Motivation;National Institute on Alcohol Abuse and Alcoholism;negative affect;Negative Reinforcements;novel;Participant;Pathway interactions;Patient Self-Report;Persons;Phase;Positioning Attribute;positive emotional state;Positive Reinforcements;Postdoctoral Fellow;Prevention;Process;Psychological reinforcement;Psychology;Regulation;reinforcer;Reporting;Research;Resources;response;Risk;Scientist;skills;Smoking;sobriety;Sum;symposium;Symptoms;Testing;theories;Training;Translating;Universities;Washington

PROJECT_TITLE: Exploring affect-motivated alcohol use as a value-based decision-making process

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Narrative: Aging and APOE4 genotype are the strongest risk factor for Alzheimer's disease (AD). However, how these risk factors affect the homeostatic microglial function and responses to amyloid  (A) prior to AD pathology remains unclear. I will determine the specific mechanism by which APOE4 contributes to these dysregulations using a targeted replacement APOE mice expressing GFP in microglia by doing whole RNA-seq analysis of microglia, and studying microglia responses to A ex-vivo, potentially identifying a new AD therapeutic target.

PI_NAMEs: SEPULVEDA, JORDY F (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Acute;Adverse effects;Affect;Affinity;age effect;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapeutic;Amyloid;Animal Model;animal old age;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Attention;Award;axon growth;Bilateral;Bioinformatics;Biological Assay;blood-brain barrier crossing;Brain;career;Cell Separation;Cells;Cholesterol;cholesterol transporters;Chronic;Committee Members;Communication;Complex;Confocal Microscopy;Dementia;Dendritic Spines;density;Development;differential expression;Doctor of Philosophy;Down-Regulation;Ensure;experimental study;Exposure to;Fellowship;Flow Cytometry;Future;Gene Expression;Genes;genetic risk factor;Genetic Transcription;Genotype;Goals;Human;Image;Immune system;Immunomodulators;in vivo imaging;induced pluripotent stem cell;Inflammation;Inflammatory;Infusion procedures;innovation;Institution;interest;Knock-in Mouse;Learning;lipid metabolism;Lipids;Manuscripts;Measurement;Measures;Mentors;Mentorship;Methods;Microglia;Microscopy;Molecular;monomer;Motility;mouse model;Movement;multiple omics;Mus;Myelogenous;Myeloid Cells;Nerve Degeneration;Nervous System Disorder;neuroinflammation;neuronal growth;Neurons;neurotoxicity;novel;Onset of illness;Pathway interactions;Peripheral;Phagocytosis;Phenotype;Positioning Attribute;Postdoctoral Fellow;pre-clinical;prevent;Process;promoter;Proteins;Purinoceptor;receptor;Research;Research Project Grants;Resources;response;Risk Factors;RNA;Rodent Model;sex;skills;Slice;symposium;synaptogenesis;therapeutic target;Training;transcriptome;transcriptome sequencing;uptake;Work

PROJECT_TITLE: The effects of APOE genotype in homeostatic microglial function in preclinical APOE mouse model

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics

PHR: Project Narrative Ameloblasts are the only epithelial cells that are capable of generating calcified tissue during development. A lack of knowledge of the unique transcriptional regulation for ameloblasts has limited our ability to regenerate these cells and enamel, a nonregenerative tissue. This proposal brings experts from enamel biology, chromatin regulation, and protein biochemistry field together to address how distinct nuclear factors coordinately regulate the transcription of ameloblastin and enamelin, the biomarkers of functional ameloblasts, and causative genes of amelogenesis imperfecta.

PI_NAMEs: ZHANG, YAN  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Ablation;Acetylation;Address;Affect;ameloblastin;Ameloblasts;Amelogenesis;Amelogenesis Imperfecta;amelogenin;Architecture;AT Rich Sequence;ATAC-seq;base;Binding;Binding Proteins;Binding Sites;Biological Markers;Biology;Biomedical Engineering;calcification;Calcium;Cell Line;cell regeneration;Cells;Characteristics;Chromatin;Complex;CRISPR/Cas technology;Data;Dental Enamel;Deposition;Development;DNA Binding;Down-Regulation;Enamel Formation;enamel matrix proteins;Enamel Organ;enamelin;Endocytosis;Enhancers;Environmental Risk Factor;Epigenetic Process;Epithelial Cells;extracellular;Fracture;Funding;Gene Cluster;Gene Expression;Gene Expression Profile;Genes;genetic signature;Genetic Transcription;Genome engineering;genome-wide;genomic locus;Genomics;Glutamine;Grant;Hardness;HIF1A gene;High Pressure Liquid Chromatography;Histone Acetylation;Hydrolysis;Hypoxia;In Vitro;in vivo;Ion Transport;Knowledge;Mediating;mineralization;Modeling;Molecular Conformation;Mus;Natural regeneration;novel;Nuclear;Organ Culture Techniques;Oxidative Stress;Peptide Hydrolases;Peptides;Proline;Protein Biochemistry;protein degradation;Rattus;Regulation;repaired;Reporter;Repression;resilience;Resistance;Resolution;response;Role;scaffold;Site;Sodium;Testing;Tissues;Tooth eruption;Tooth structure;transcription factor;Transcriptional Regulation;transcriptome sequencing;Up-Regulation;uptake;Vertebrates

PROJECT_TITLE: The stage-specific regulation of ameloblastin and enamelin by the distinct nuclear factors

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]