ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: NARRATIVE Phase 2 of the “Center for Translational Viral Oncology” (CTVO) will leverage success of Phase 1coupled to evolving research themes that incorporate new faculty expertise and health-disparate, cancer prone populations in our region to study virus-induced malignancies. These cancers are highly prevalent in Louisiana and occur at increased incidence in people living with HIV. The overarching goal of CTVO is to improve disease management and quality of life across the diverse spectrum of Louisiana cancer patients through responsive research activity including the following 1) sustaining the career development of talented Junior Principal Investigators (JPIs) 2) supporting existing and coalescing research between regional scientists in viral oncology and 3) reinforcing the institutionalization of productive core facilities.

PI_NAMEs: WEST, JOHN T. (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Academic Medical Centers;Address;Advisory Committees;Advocate;African;Anogenital cancer;Basic Science;biobank;Bioinformatics;Biomedical Research;Biometry;Black Populations;Budgets;Cancer Patient;cancer risk;career development;Cellular Immunology;Centers of Research Excellence;Cervical;chronic infection;Clinical;Clinical Investigator;clinical material;clinical translation;co-infection;Collaborations;Core Facility;CRISPR/Cas technology;Dedications;design;Development;Disease Management;Drug resistance;Education;Endogenous Retroviruses;Ensure;Epigenetic Process;epigenetic regulation;Etiology;Evaluation;Faculty;Familiarity;Funding;gene interaction;Glioblastoma;Goals;Growth;health disparity;Health Sciences;high reward;high risk;Histopathology;HIV;HIV-1;Human;Human Herpesvirus 4;Human Herpesvirus 8;Human Papillomavirus;Immune;Immune System Diseases;immunoregulation;improved;improved outcome;Incidence;Inflammation;Infrastructure;Infusion procedures;innovation;Institution;Institutionalization;Interdisciplinary Study;interest;investigator training;Kaposi Sarcoma;Louisiana;Malignant - descriptor;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Mentors;Mentorship;Metabolism;metabolomics;Microscopy;Minority Groups;Molecular;monocyte;National Institute of General Medical Sciences;NCI Center for Cancer Research;Neoplasms;Not Hispanic or Latino;novel;Oncology;Outcomes Research;Pathway interactions;Patients;Persons;Phase;Pilot Projects;Population;Principal Investigator;Productivity;Program Development;programs;Quality of life;recruit;Regulation;Research;Research Activity;Research Personnel;Research Project Grants;research study;Research Support;Role;Sarcoma;Scientist;Signal Transduction Pathway;stemness;Structure;success;synergism;Talents;Teacher Professional Development;Testing;Training;translational approach;translational genomics;Translations;tumor;tumorigenesis;United States National Institutes of Health;Universities;vector;Viral;Viral Cancer;Viral Genes;virology;Virus;Virus Diseases;virus host interaction;virus related cancer;Vision;Woman

PROJECT_TITLE: Center for Translational Viral Oncology (CTVO)


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PROJECT_TERMS: Academic Medical Centers;Achievement;Advisory Committees;Affect;Awareness;Basic Science;Bioinformatics;Biomedical Research;Cancer Center;Cancer Etiology;career development;Centers of Research Excellence;Clinical;Clinical Research;Clinical Sciences;Clinical Trials Unit;Collaborations;community engagement;Computerized Medical Record;Core Facility;Dedications;design;Development;Development Plans;Economics;Educational process of instructing;Ensure;Environment;Equity;Ethnic Origin;Evaluation;experience;forging;Funding;Future;Gender;Grant;Health;health disparity populations;Health Sciences;Homeostasis;improved;improved outcome;Institution;Instruction;Interdisciplinary Study;interest;International;Journals;Leadership;Louisiana;Malignant - descriptor;Malignant Neoplasms;Manuscripts;meetings;Mentors;minority patient;Modality;Morbidity - disease rate;mortality;NCI Center for Cancer Research;Newsletter;novel;Oncology;operation;Patient Care;patient population;Patient-Focused Outcomes;Patients;Peer Review;Phase;Pilot Projects;Preventive;Process;Productivity;Program Development;programs;Research;Research Personnel;Research Project Grants;Research Proposals;research study;Research Support;Resources;Role;Scientist;Strategic Planning;Structure;Teacher Professional Development;Techniques;Testing;Therapeutic;Training;Translational Research;Translations;tumor registry;Universities;Viral;Viral Cancer;Virus;virus host interaction;virus related cancer

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome

PI_NAMEs: ZABALETA, JOVANNY  (contact)

PROJECT_TERMS: Academic Medical Centers;African American;anti-cancer research;Area;Basic Science;Bioinformatics;Biology;Biometry;Cancer Center;Caucasians;Cellular Immunology;Centers of Research Excellence;ChIP-seq;Clinical;Clinical Research;Clinical Trials Network;Collaborations;Communities;Continuing Education;Contract Services;cost effectiveness;Data;Data Analyses;data exchange;Development;Dideoxy Chain Termination DNA Sequencing;Disease;Elements;Epigenetic Process;epigenomics;Equipment;Ethnic Origin;exome sequencing;experience;Experimental Designs;Faculty;Feedback;Funding;Genetic;Genetic Markers;Genetic study;Genomic Segment;Genomics;Goals;Grant;health disparity;Histopathology;Human Resources;Immune;improved;Infection;Inflammatory;Informatics;Infrastructure;Institution;instrumentation;International;Laboratories;Link;Louisiana;Macaca;Maintenance;Malignant Neoplasms;Medical center;medical schools;Medicine;Mentors;Metabolism;Methylation;Microscopy;Minority;Minority Groups;Mississippi;Molecular;NCI Center for Cancer Research;Neuroendocrine Tumors;new technology;next generation sequencing;Nucleic Acids;Obesity;Oncology;Patients;Phase;Pilot Projects;Policies;Positioning Attribute;pre-clinical;Preventive;Price;Principal Investigator;programs;Protocols documentation;Research;Research Infrastructure;Research Personnel;Research Project Grants;research study;Sampling;Science;Services;single cell genomics;single cell sequencing;Site;SIV;Structure;Students;success;Techniques;Technology;technology development;Tissues;Training;transcriptome;transcriptome sequencing;translational genomics;translational goal;Translational Research;triple-negative invasive breast carcinoma;tumor immunology;United States National Institutes of Health;Universities;Update;Variant;Vendor;Viral

PROJECT_TITLE: Translational Genomics Core


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Lung Cancer;Precision Medicine;Prevention;Rare Diseases;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Exposure to indoor and outdoor air pollution in India is strongly associated with the risk for cancers of the aerodigestive tract, including lung cancer and head and neck cancer. Biomarkers of air pollutant exposure and effect can serve as powerful tools in identifying individuals or populations at risk and informing the development of preventive measures. This study will develop capacity for biomarker research in India and will generate important new knowledge of the role of air pollution in the risk for aerodigestive tract cancer in nonsmokers.

PI_NAMEs: DIKSHIT, RAJESH ;STEPANOV, IRINA  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;adduct;Aerodigestive Tract;Air Pollutants;Air Pollution;air sampler;air sampling;Albumins;Aldehydes;ambient air pollution;anti-cancer research;Area;Aromatic Polycyclic Hydrocarbons;Biological;Biological Assay;Biological Markers;Biological Monitoring;biomarker panel;Cancer Center;cancer epidemiology;cancer prevention;cancer risk;carcinogenicity;Carcinogens;case control;Case/Control Studies;chemical carcinogen;Chemicals;cohort;Cohort Studies;Collaborations;Cotinine;Country;Data;demographics;design;Development;Devices;dietary;disorder risk;Epidemiology;expectation;experience;Exposure to;Frequencies;Future;Goals;Head and Neck Cancer;head and neck cancer patient;High Prevalence;India;Individual;Indoor Air Pollution;insight;Intervention;Investigation;Knowledge;Laboratories;Laboratory Research;Life Style;Malignant neoplasm of larynx;Malignant neoplasm of lung;Malignant Neoplasms;malignant oropharynx neoplasm;Measurement;Measures;Metals;metropolitan;Minnesota;non-smoker;non-smoking;novel;novel marker;Occupational Exposure;Occupations;Oral;Outcome Study;oxidative DNA damage;Participant;phenotypic biomarker;Plasma;Policies;pollutant;Population;Populations at Risk;Preventive measure;Questionnaires;recruit;Research;residence;Risk;Risk Factors;Role;Sampling;Site;Smokeless Tobacco;smokeless tobacco use;smokeless tobacco user;Smoker;Smoking;smoking prevalence;Source;specific biomarkers;Subgroup;Testing;Tobacco;Tobacco use;tool;toxicant;Universities;University of Minnesota Cancer Center;uptake;Urine

PROJECT_TITLE: Biomarker phenotypes of air pollution and cancer risk in India


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LIN, HUI-YI  (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;analytical method;analytical tool;Area;Basic Science;Bioinformatics;bioinformatics pipeline;bioinformatics tool;Biometry;Biostatistical Methods;Clinical;cluster computing;Collaborations;Communicable Diseases;Communication;Custom;Data Analyses;Data Analytics;Data Collection;data integration;data management;Data Management Resources;data sharing;design;Development;Emerging Technologies;empowerment;Ensure;Environment;Environment Design;Experimental Designs;experimental study;faculty research;Formulation;Fostering;Funding;Genomics;Goals;Grant;Health Sciences;High Performance Computing;Human Resources;Information Dissemination;innovation;Journals;Knowledge;Laboratories;Louisiana;Machine Learning;member;Methodology;Methods;multidimensional data;Nature;new technology;novel;Oncology;Paper;Performance;Phase;Pilot Projects;Play;Principal Investigator;programs;Publications;Publishing;Reporting;Research;Research Activity;Research Design;Research Personnel;Resources;Role;Science;scientific computing;Scientist;Services;Statistical Methods;success;support tools;Teacher Professional Development;Technology;tool;Training;Translational Research;Universities;Viral;virology;Visualization;Writing

PROJECT_TITLE: Biostatistics and Bioinformatics Core


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Genetics;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The intestinal epithelium plays critical roles in digestion and pathogen defense, and its integrity is maintained by a pool of proliferative intestinal stem cells. Recently a population of subepithelial mesenchymal telocytes have been identified as a critical niche population supplying cytokines to support stem cell activity. We address whether telomere dysfunction, which occurs during natural ageing and pathologically in telomeropathies, results in intestinal stem cell failure due to a loss of extrinsic niche support from the telocyte stem cell niche.

PI_NAMEs: KIM, MELISSA  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Ablation;Address;Alleles;beta catenin;Biological;Biological Assay;Biology;Blood;Bone Marrow;Bone marrow failure;Bone Marrow Transplantation;Cell Compartmentation;Cells;Chromatin Structure;Chromosomes;Clinical;Coculture Techniques;cytokine;Data;Defect;Digestion;Disease;DNA Damage;Down-Regulation;Dyskeratosis Congenita;Engraftment;Enterocolitis;Epithelium;Exhibits;Failure;Feedback;FOXL1 gene;Functional disorder;functional restoration;Future;gastrointestinal;Gastrointestinal Diseases;Gene Expression;Gene Targeting;Genes;Genetic;Germ-Line Mutation;Goals;Hour;Human;In Situ;in vivo;Inherited;insight;interest;intestinal crypt;intestinal epithelium;Intestines;Knock-in;Lamina Propria;Length;Ligands;Light;Link;LoxP-flanked allele;Maintenance;Malabsorption Syndromes;Mesenchymal;Modeling;Morphology;mouse model;Mucous Membrane;Mus;mutant;Natural regeneration;normal aging;novel;Organoids;pathogen;Pathologic;Pathology;Pathway interactions;Patients;Phenocopy;Phenotype;Play;Population;premature;prevent;Proliferating;Reporter;response;restoration;RNA;RNA-Directed DNA Polymerase;Role;self-renewal;Series;Signal Transduction;single-cell RNA sequencing;Skin;Source;stem cell function;stem cell genes;stem cell niche;stem cell self renewal;stem cells;Supporting Cell;System;Telomerase;Telomerase RNA Component;telomere;Telomere Capping;Telomere Maintenance;Telomere Shortening;Telomeric Repeat Binding Protein 2;Therapeutic;Tissues;transcriptomic profiling;Transplantation;Ulcer;Visualization;WNT Signaling Pathway;Work

PROJECT_TITLE: Investigating the role of telomere failure on intestinal stem cell niche function


NIH_SPENDING_CATS: Genetics

ORG_CITY: Aurora

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative/Public Health Relevance Regulation of gene expression is essential for cellular differentiation, development, and homeostasis. Mediator, a large and dynamic multi-protein complex conserved in all eukaryotic organisms, plays an indispensable role in gene expression regulation. We will use biochemistry, genetics, macromolecular electron microscopy and advanced image analysis techniques, to discover how Mediator performs its essential function in control of gene expression. The results of our studies are critical to public health because dysregulation of gene expression is directly connected to developmental disorders, cancer and other human pathologies.

PI_NAMEs: ASTURIAS, FRANCISCO J (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: antagonist;Binding;Biochemical;Biochemistry;Bioinformatics;Biological;Cell Differentiation process;Code;Communication;Complex;Cryoelectron Microscopy;Development;developmental disease;DNA;Electron Microscopy;Elements;Enabling Factors;Enhancers;Enzymes;Eukaryota;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;Genetic Transcription;Genomics;Head;Homeostasis;Human Pathology;Image Analysis;In Vitro;in vivo;Individual;innovation;interdisciplinary approach;Link;Location;Malignant Neoplasms;Maps;Mediator;Mediator of activation protein;Modeling;Molecular Biology;Molecular Conformation;Multiprotein Complexes;novel;Nuclear Receptors;Organism;paralogous gene;Phosphotransferases;Play;polypeptide;Process;Proteins;Public Health;public health relevance;recruit;Regulation;Repression;Research;Resolution;response;RNA Polymerase II;RNA polymerase II largest subunit;Role;Signal Transduction;structural determinants;Structure;Tail;Techniques;Testing;transcription factor;transcription factor TFIIH;Transcription Initiation;Transcriptional Activation;Transcriptional Regulation;Work

PROJECT_TITLE: Structural studies of eukaryotic transcription


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer

PI_NAMEs: DEL VALLE, LUIS  (contact)

PROJECT_TERMS: Animal Experiments;Animals;Antibodies;Applications Grants;Archives;Autopsy;biobank;Biological Assay;Biopsy Specimen;Board Certification;cancer cell;Cell Culture Techniques;Cell model;Cell surface;Cells;Cellular Structures;Centers of Research Excellence;Clinical;Collaborations;Collection;Comet Assay;Confocal Microscopy;Data;data submission;Dedications;design;Detection;detection method;Development;digital;DNA;DNA Probes;Evaluation;experience;Extramural Activities;fluorescence microscope;Funding;Generations;Genes;Grant;health organization;Histologic;Histological Techniques;Histology;Histopathology;HIV;Human;human disease;Image;Image Analysis;imaging study;imaging system;Imaging Techniques;Immunofluorescence Immunologic;Immunohistochemistry;In Situ;In Situ Hybridization;In Vitro;Individual;Infection;instrumentation;Label;Ligation;Louisiana;Malignant Neoplasms;Manuscripts;Mentors;Messenger RNA;Methodology;Methods;Microscope;Microscopic;Microscopy;Mission;Molecular;nature center;NCI Center for Cancer Research;Neoplasms;neoplastic;Normal tissue morphology;Oncology;Pathologist;Pathology;Pathway interactions;Patients;Phase;Photography;Principal Investigator;Process;programs;prospective;Protein Dynamics;protein expression;Proteins;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;RNA;RNA Probes;RNA-Protein Interaction;Sampling;Services;Technical Expertise;Techniques;tissue processing;Tissues;Training;Translational Research;tumor;tumor registry;Tumor Tissue;United States National Institutes of Health;Universities;Viral;Viral Proteins;virus related cancer;Work

PROJECT_TITLE: Molecular Histopathology and Analytical Microscopy Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Cardiovascular;Childhood Leukemia;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Although chemotherapy related cardiac toxicity is associated with decreased survival outcomes in children receiving treatment for acute myeloid leukemia (AML), there are no clinical prediction models for incident cardiac toxicity or trajectories of the progression or resolution of cardiac dysfunction. The well described disparities in survival outcomes by race and ethnicity in pediatric AML have not included analyses of echo monitoring adherence or subsequently identified cardiac dysfunction. This application seeks to address these knowledge gaps with following three specific aims: (1) Develop and validate dynamic prediction models for incident early chemotherapy associated LVSD, defined as ejection fraction (EF) ≤50% or fractional shortening (SF) ≤24%, in pediatric AML patients; (2) develop and validate prediction models for latent phenotypes defined by distinct trajectories of LV function based on longitudinal echo-derived measures of LVEF in pediatric AML patients, and (3) identify disparities in off-therapy echo monitoring, early incident chemotherapy associated LVSD, and evaluate their role as intermediates in disparities in survival outcomes.

PI_NAMEs: APLENC, RICHARD  (contact);GETZ, KELLY DIRINGER

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Acute;Acute Myelocytic Leukemia;Address;Adherence;Algorithms;analytical method;Anthracycline;Area;cancer therapy;Cardiac;Cardiomyopathies;Cardiotoxicity;chemotherapy;Child;Childhood;Childhood Acute Myeloid Leukemia;childhood cancer survivor;Clinical;clinical practice;clinical predictive model;clinical trial enrollment;Clinical Trials;Clinical Trials Cooperative Group;cohort;cost;Data;Data Set;Data Sources;Derivation procedure;Detection;Development;Disparity;early experience;early onset;Echocardiography;EFRAC;Ensure;ethnic disparity;ethnic minority;Ethnic Origin;Evaluation;evidence based guidelines;experience;Frequencies;Functional disorder;Future;Genetic;Genomics;Goals;Guidelines;Heart failure;heart function;improved;improved outcome;indexing;Insurance;Insurance Coverage;Intervention;Intervention Studies;Joints;Knowledge;Left;Left Ventricular Ejection Fraction;Left ventricular structure;leukemia relapse;leukemia treatment;Life;Measurement;Measures;Mediating;Modeling;Modification;Monitor;Myocardial dysfunction;Neoadjuvant Therapy;novel;Outcome;outcome disparities;participant enrollment;patient population;Patients;Pattern;Pediatric Oncology Group;pediatric patients;Performance;personalized chemotherapy;Pharmaceutical Preparations;Phase;Phenotype;Play;predictive modeling;preservation;Publishing;Race;racial disparity;racial minority;Randomized;Recommendation;Recovery;relapse risk;Reporting;Resolution;Risk;Role;Schedule;Shortening Fraction;social health determinants;socioeconomics;survival outcome;survivorship;Testing;Time;Toxic effect;Treatment outcome;Treatment-related toxicity;Update;Validation;Ventricular;whole genome;Work

PROJECT_TITLE: Predicting and Monitoring for Cardiac Toxicity in Pediatric AML

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Patient Safety;Racial and Ethnic Minority Health Research

PI_NAMEs: SUBBIAH, SUKI  (contact)

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Address;Advisory Committees;Affect;African American;Ambulatory Care Facilities;anti-cancer research;Area;Articulation;biobank;biomedical referral center;cancer care;Cancer Center;Cancer Diagnostics;Caring;Centers of Research Excellence;Characteristics;Clinic;Clinical;Clinical Data;Clinical Research;clinical translation;clinically relevant;co-infection;Collaborations;Collection;Communicable Diseases;cost;Cytotoxic Chemotherapy;Data;Diagnosis;Drug Interactions;Drug resistance;Economics;Enrollment;Ensure;Environment;Epidemic;epidemiologic data;Ethics;Ethnic Origin;Funding;gene-editing approach;Genetic;Goals;Grant;Health;health disparity;Healthcare Systems;high risk;HIV;HIV therapy;HIV-1;HIV/AIDS;Human;Human Resources;human subject protection;immune modulating agents;Immunologics;improved;Incidence;Individual;Infection;Institution;Laboratories;Link;Louisiana;Malignant Neoplasms;Minority;Minority Groups;minority health disparity;mortality;Neoplasms;Oncogenic Viruses;Oncology;Outcome;patient population;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;Phenotype;Population;Positioning Attribute;preference;Principal Investigator;Privacy;programs;Public Health Schools;Research;Risk;Sampling;Services;social;standard of care;stemness;System;Therapeutic;Toxic effect;Translational Research;tumor;tumor registry;underserved minority;Update;Viral;Viral Cancer;Virus;Virus Latency;virus related cancer;volunteer;Wood material;Work

PROJECT_TITLE: HIV Clinical Tumor Biorepository


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PI_NAMEs: TSO, FOR YUE  (contact)

PROJECT_TERMS: Adherence;Affect;Africa South of the Sahara;AIDS related cancer;AIDS with Kaposi's sarcoma;Antigen Presentation;antiretroviral therapy;Area;Attenuated;Base Sequence;Bioinformatics;Burkitt Lymphoma;Cell Culture Techniques;Cell model;Cells;Chronic;Country;Coupled;CRISPR/Cas technology;design;Development;Etiology;experience;Gene Expression;gene interaction;Genes;Geography;Growth;health disparity;Herpesviridae Infections;HIV;HIV-1;Human Herpesvirus 4;Human Herpesvirus 8;Immune;Immune Evasion;Immunologic Surveillance;immunoregulation;Incidence;Individual;infection rate;insight;Kaposi Sarcoma;latency-associated nuclear antigen;Louisiana;Maintenance;Malignant - descriptor;Malignant neoplasm of nasopharynx;Malignant Neoplasms;malignant phenotype;Mentored Clinical Scientist Development Program;MicroRNAs;Modeling;Monitor;Multicentric Angiofollicular Lymphoid Hyperplasia;Neoplasms;neoplastic cell;new technology;novel;Oncogenic;Oncology;Pathway interactions;people of color;Persons;Play;primary effusion lymphoma;programs;Property;protein expression;Reporting;Research;Resistance;Risk;Role;Seroprevalences;System;Testing;Therapeutic;transcriptome;transcriptome sequencing;tumorigenesis;United States;vector;Viral;Viral Cancer;Viral Genes;Viral Load result;Virus;Virus Diseases;Virus Latency

PROJECT_TITLE: Project 2-Tso


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PHR: PROJECT NARRATIVE Our recent multimodal brain imaging studies have shown that quantification of auditory white matter microstructure (measured via diffusion-MRI) can model, or predict, the timing of a brain’s response to a sound (measured via magnetoencephalography (MEG)), and that with this technique we can identify an “outlier” sub-population of children with autism spectrum disorder (ASD) who are also deficient in a brain neurochemical called GABA, important in regulating brain function and a candidate for biological treatment targets. The present study extends this work to the scientifically and societally critical group of children with ASD with severe language and cognitive impairment, whose participation in this multimodal brain imaging study is made possible via a behavioral and technical protocol we have recently developed, called MEG-PLAN. With the inclusion of clinical control groups (children with intellectual and developmental disability without autism and children with specific language impairment but absent general cognitive impairment), we will first identify the relative associations of language impairment, cognitive impairment and ASD symptoms to a delayed auditory response, and then investigate the biophysical underpinnings of these associations with auditory cortex white matter and auditory cortex GABA levels.

PI_NAMEs: ROBERTS, TIMOTHY P (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acoustics;Address;Affect;Age;analog;applied behavior analysis;Auditory;Auditory area;auditory pathway;auditory processing;autism spectrum disorder;autism symptoms;autistic children;Behavioral;Biological;Biological Assay;biological heterogeneity;Biological Markers;Biological Response Modifier Therapy;Biophysics;Brain;Brain imaging;Chemicals;Child;Child Development;Clinical;Clinical assessments;cognitive ability;cohort;combat;Control Groups;Data;Dependence;design;Development;Diagnosis;Diagnostic;Diffusion Magnetic Resonance Imaging;Electrophysiology (science);Etiology;Exhibits;follow-up;Frequencies;gamma-Aminobutyric Acid;Heterogeneity;Image;imaging approach;imaging study;Impaired cognition;Impairment;improved;inclusion criteria;indexing;insight;Intellectual functioning disability;interest;Intervention;Language;language impairment;lexical;lexical processing;Linear Models;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Magnetoencephalography;Measures;Meta-Analysis;Methodology;minimally verbal;model development;model of autism spectrum disorder;Modeling;multimodality;neural circuit;Neurobiology;neurochemistry;neuroimaging;neuronal circuitry;Neurotransmitters;non-verbal;Pathway interactions;peer;Performance;Phenotype;Population;predicting response;prognostic;Protocols documentation;Radiation;Reaction Time;recruit;Research;response;Response Latencies;Role;School-Age Population;Selection for Treatments;social;sound;specific language impairment;Specificity;Stimulus;Stratification;Structure;Techniques;vector;verbal;white matter;Work

PROJECT_TITLE: Multimodal dMRI, MRS and MEG studies of language impairment in low-verbal ASD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-E(02)M]


NIH_SPENDING_CATS: Genetics;Human Genome;Pediatric

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE In embryonic development, gastrulation is a pivotal process for the differentiation of all the lineages and the cells types that descent from them. Our proposed studies aim to understand how genome three-dimensional (3D) reorganization helps establish each lineage in gastrulation, how well these reorganizations are conserved within each lineage, and how they are disrupted by epigenetic perturbations that are associated with diseases. This research may reveal novel mechanisms for human development and epigenetic diseases and thus empower therapeutic strategies.

PI_NAMEs: KALHOR, REZA  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: 3-Dimensional;Address;Affect;Architecture;Bar Codes;Biological Assay;Cell Differentiation process;cell type;Cells;Chromatin;combinatorial;Congenital Abnormality;Data;Daughter;daughter cell;Development;Disease;DNA;DNA Methylation;Ectoderm;Embryo;Embryonic Development;empowerment;Endoderm;Epigenetic Process;Event;gastrulation;Gene Activation;Gene Expression;Gene Expression Profile;Genetic Transcription;Genome;Genomics;Germ Layers;Goals;Heritability;Heterogeneity;Hi-C;histone modification;Histones;Human;Human body;Human Development;human disease;in vivo;Inherited;Inner Cell Mass;insight;Knockout Mice;Ligation;Measures;member;Mesoderm;Mitosis;Mitotic;Molecular;mouse model;Mus;Neurodevelopmental Disorder;novel;Organogenesis;Population;Process;programs;reconstruction;Research;response;Role;Specific qualifier value;Spontaneous abortion;Structure;success;System;Testing;Therapeutic;three dimensional structure;tool;transmission process;Variant;zygote

PROJECT_TITLE: Dynamics of lineage-specific genome reorganization in gastrulation and their response to disease-associated epigenetic perturbations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(71)R]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: RAK, MONIKA  (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Area;Astrocytoma;attenuation;Binding;BMI1 gene;Brain;Brain Neoplasms;c-myc Genes;cancer stem cell;Cancer Vaccines;CD44 gene;cell type;Cells;Childhood Brain Neoplasm;Classification;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Data;Databases;derepression;Detection;Development;Down-Regulation;Drug resistance;drug resistance development;Elements;epigenomics;Excision;Formalin;Freezing;Gene Silencing;Genes;Genetic Transcription;Germ Cells;Glioblastoma;Glioma;Growth;Hematopoietic stem cells;Human;Human Development;Human Genome;Immune checkpoint inhibitor;in silico;inhibitor;Investigation;Knowledge;Link;Long Terminal Repeats;Maintenance;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;malignant phenotype;Maps;Measures;Mesenchymal;Molecular;Mus;Neural Cell Adhesion Molecule L1;novel;novel strategies;novel therapeutic intervention;Oncology;Operative Surgical Procedures;Outcome;overexpression;Paraffin Embedding;particle;Pathway interactions;Patients;Pattern;Phenotype;pluripotency;Population;promoter;protein biomarkers;Proteins;Radiation therapy;Recurrence;Recurrent tumor;Regimen;Repression;Retrotransposon;Retroviridae;Role;Sampling;self-renewal;Somatic Cell;standard of care;stem;stem cell biomarkers;stem cells;stemness;System;temozolomide;Terminal Repeat Sequences;Testing;The Cancer Genome Atlas;Therapeutic;tool;Transcript;transcription factor;transcriptome;transcriptome sequencing;tumor;tumor microenvironment;United States;Up-Regulation;vector;Viral;Viral Proteins

PROJECT_TITLE: Project 4-Monika Rak


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE State and federal policymakers have increasingly expanded insurance coverage for gender affirming services, which could reduce health inequities for the nearly 2 million gender minority (i.e., transgender and gender diverse) individuals in the U.S. This study will examine the implementation of gender affirming coverage policies in Medicaid to inform ongoing policy debates regarding the adoption of such policies. Through the research and training in this Mentored Research Scientist Career Development Award, the candidate will be prepared to pursue innovative research to improve health care access and outcomes for sexual and gender minority communities.

PI_NAMEs: MCDOWELL, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Policy effects on gender minority health and evidence from the implementation of gender affirming coverage in Medicaid

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Nanotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: OCHOA, AUGUSTO C. (contact)

PROJECT_TERMS: Affect;Aging;anti-cancer research;Autophagocytosis;Biological Assay;Biological Markers;Biological Response Modifiers;biomarker identification;Biopsy;Cancer Center;cancer stem cell;Cell Culture Techniques;Cell Death;cell growth;Cell Proliferation;Cell Separation;Cell Survival;Cell-Mediated Cytolysis;Cells;Cellular Immunology;Centers of Research Excellence;Collaborations;Color;Communities;cytokine;Cytometry;Data;Detection;Development;Disease;Drug Delivery Systems;Drug Evaluation;Effectiveness;effector T cell;Energy Metabolism;Environment;Equipment;equipment training;Evaluation;experimental study;Fatty Acids;Flow Cytometry;Frequencies;Funding;Funding Mechanisms;Gene Expression;Genomics;Genus Hippocampus;glucose uptake;Goals;Growth;Health system;High Pressure Liquid Chromatography;Human Resources;Hypoxia;Image;immune activation;Immunoassay;Immunologic Markers;Immunology;Immunosuppression;improved;Inflammation;Infrastructure;innovation;innovative technologies;Institution;instrument;instrumentation;Internet;Laboratories;Laboratory Personnel;Link;Louisiana;Malignant Neoplasms;Mediation;medical schools;meetings;Mentors;Messenger RNA;Metabolic;Metabolism;metabolomics;microvesicles;Mitochondria;Mitogens;nanoparticle;Nanotechnology;NCI Center for Cancer Research;neoplastic cell;new technology;Nitrogen;novel;novel therapeutics;Oncology;Oxygen;Oxygen Consumption;Participant;Pathway interactions;Phase;Policies;Population;Positioning Attribute;Principal Investigator;Production;Proliferating;Protocols documentation;Research;Research Personnel;Research Project Grants;Research Support;response;Running;Services;Signal Transduction;single cell technology;Social Distance;social media;Speed;stem cell biomarkers;stemness;Technology;Teleconferences;Time;Tissues;Training;Translational Research;translational scientist;tumor;tumor metabolism;tumor microenvironment;tumorigenesis;Universities;Update;Viral;Virus;virus related cancer;Work

PROJECT_TITLE: Cellular Immunology Metabolism Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DETROIT

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The difficulty in early, reliable prediction of drug penetration into the human brain and brain tumors makes the development of new drugs and use of existing drugs for treating brain cancer a challenging and usually unsuccessful task. This project will develop a physiologically based pharmacokinetic model platform that will improve our ability to more readily and reliably predict the levels of anticancer drugs in the human brain and brain tumors. This mechanism-based computational model platform promises to become a valuable tool to assist drug developers and health care providers in the development of more effective therapies and optimal use of current therapies to treat brain cancer.

PI_NAMEs: LI, JING  (contact);SANAI, NADER

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Active Biological Transport;Affect;Animal Model;Antineoplastic Agents;Area;Biochemical;Biological Models;biological systems;Blood - brain barrier anatomy;blood perfusion;blood-brain barrier disruption;blood-brain barrier function;blood-brain barrier permeabilization;blood-brain tumor barrier;Brain;Brain Neoplasms;brain parenchyma;Cardiovascular system;Carrier Proteins;Central Nervous System;Cerebral cortex;Characteristics;Clinical;clinical development;Clinical Pharmacology;Clinical Trials;Collaborations;comparative;Computer Models;contrast enhanced;Data;Data Set;Decision Making;design;Development;Diffusion;Dose;Drug Delivery Systems;drug development;Drug Kinetics;Drug Modelings;effective therapy;Enzymes;Formulation;Glioblastoma;Goals;Health Personnel;Heterogeneity;Human;improved;In Vitro;in vitro Assay;in vitro Model;in vivo;Individual;Infiltration;innovation;inter-individual variation;inter-institutional;Kinetics;Knowledge;Malignant neoplasm of brain;Mediating;Metabolism;Methods;model development;Modeling;Necrosis;neurosurgery;novel;novel therapeutics;Oncology;Outcome;Patients;Penetration;Permeability;Pharmaceutical Preparations;pharmacokinetic model;Pharmacology;Pharmacology Study;Pharmacotherapy;Physiological;physiologically based pharmacokinetics;Plasma;pre-clinical;Predictive Factor;predictive modeling;Process;programs;Property;Proteins;Proteomics;Regimen;restraint;SDZ RAD;small molecule;Specimen;Structure;System;tool;Translational Research;translational research program;tumor;uptake;Validation

PROJECT_TITLE: Physiologically Based Pharmacokinetic Modeling of Drug Penetration into the Human Brain and Brain Tumors


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Nutrition;Obesity;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Relevance to Public Health Retinal disease remains a major cause of legal blindness. Despite advances in the genetics of retinal degeneration, in many cases, the pathogenic processes have defied elucidation. The work proposed in the application will address disease mechanisms that accompany obesity and involve vitamin A and by-products of the visual cycle.

PI_NAMEs: SPARROW, JANET RUTHE (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 11 cis Retinal;Abbreviations;Acceleration;Acute;adduct;Age related macular degeneration;Aldehydes;All-Trans-Retinol;American;Biochemical;Bolus Infusion;burden of illness;Cellular Assay;Chromatography;Clinical;clinical diagnosis;Complex Mixtures;confocal imaging;Darkness;Deposition;Diagnosis;Diet;diet-induced obesity;Disease;disease natural history;Equilibrium;experimental study;Family;fluorophore;Fundus;fundus imaging;Gene Deletion;Genetic;genetic testing;Genotype;Glyoxal;Health;High Fat Diet;High Pressure Liquid Chromatography;Histologic;human subject;Image;Injections;Intake;International Unit;Investigation;Kinetics;Lasers;Legal Blindness;legally blind;Light;Link;lipid metabolism;Lipids;Lipofuscin;Liquid Chromatography;macromolecule;Measurement;Measures;Medical Genetics;Membrane;Metabolism;Methods;Modeling;Monitor;Mus;Mutation;non-invasive imaging;novel;Nuclear;Obese Mice;Obesity;Ophthalmoscopy;Overweight;overweight adults;Pathogenicity;Patients;Performance;Periodicity;Pharmacotherapy;Phenotype;Phosphatidylethanolamine;Photoreceptors;Population;Prevalence;Process;Proteins;Public Health;Pyruvaldehyde;Quantitative Reverse Transcriptase PCR;RBP4 gene;Reaction;Reactive Oxygen Species;Research;Retina;Retinal Degeneration;Retinal Diseases;Retinaldehyde;Retinitis Pigmentosa;Retinoids;Reverse Transcriptase Polymerase Chain Reaction;Risk;Role;Scanning;Serum;Source;Spectrometry, Mass, Electrospray Ionization;Stargardt's disease;Structure of retinal pigment epithelium;Supplementation;Testing;Time;Toxic effect;visual cycle;Vitamin A;Weight;Weights and Measures;Work

PROJECT_TITLE: Impact of Lipofuscin in Retinal Pigment Epithelial Cells

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ORG_CITY: VALHALLA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NEW YORK MEDICAL COLLEGE

PHR: Project Narrative: Cells have implemented robust stress-responsive systems that drive gene expression to cope with environmental perturbations that cause protein damages. These systems also have broader roles in animal physiology including development and reproduction, and can be hijacked in disease, such as cancer. The mission of this research is to understand the roles of the stress responsive systems in these physiological and pathological conditions, and to provide insights on regulating their activities for organismal health.

PI_NAMEs: LI, JIAN  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Abnormal Cell;Address;Animal Model;Animals;Caenorhabditis elegans;cancer cell;Cancer cell line;Cell Cycle Progression;Cell model;Cell Nucleus;Cell Proliferation;cell type;Cells;coping;Coupled;CRISPR screen;Cytosol;Development;Disease;Energy Metabolism;Future;gene drive system;Gene Expression;Genetic;Genetic Transcription;Germ Cells;Germ Lines;germline stem cells;Health;heat shock transcription factor;Heat-Shock Response;insight;Insulin-Like Growth Factor I;Knowledge;Longevity;Malignant Neoplasms;Mission;Modeling;Nematoda;Nucleosomes;Pathologic;Pathway interactions;Physiological;Physiological Processes;Physiology;PIK3CG gene;Play;programs;Proliferating;prostate cancer cell;Proteins;proteostasis;proteotoxicity;Regulation;Regulatory Pathway;Regulon;Reproduction;Research;response;Role;Signal Transduction;Specific qualifier value;stem cell proliferation;Stress;System;Therapeutic;tool;transcriptome

PROJECT_TITLE: Roles of heat shock transcriptional factor 1 in cell proliferation independent of the heat shock response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Neurosciences;Rehabilitation

ORG_CITY: COLLEGE PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: The proposed research is relevant to public health because partial restoration of hearing from a technological intervention called a bionic cochlear implant is becoming increasingly common, allowing people to obtain access to sound in both ears, but not yet providing all of the expected benefits. This research aims to maximize the benefits from implantation and two-eared hearing. Thus, the proposed research is relevant to NIH’s mission to develop new knowledge and improve technologies to help treat disability and NIDCD’s mission to provide technological interventions for hearing loss.

PI_NAMEs: BERNSTEIN, JOSHUA GARY;GOUPELL, MATTHEW J. (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustics;Affect;Amblyopia;Auditory;Auditory Perception;Auditory Perceptual Disorders;Auditory system;aural rehabilitation;Bilateral;Binaural;binaural hearing;Bionics;clinical practice;Cochlear Implants;Communication;Complex;Contralateral;Cues;Data;deafness;disability;Ear;Electrodes;Environment;experience;experimental study;Eye;Goals;Hearing;hearing impairment;hearing restoration;Impairment;implantation;improved;Individual;Influentials;innovation;Knowledge;Link;Loudness;Maps;Measures;Mediating;Mission;Modality;Modeling;National Institute on Deafness and Other Communication Disorders;Nerve Degeneration;neural;Outcome;Perception;Performance;Peripheral;Persons;Population;Predisposition;Prevalence;programs;Public Health;Publishing;rehabilitation strategy;Rehabilitation therapy;remediation;Research;Role;selective attention;Side;sound;Speech;stem;Stimulus;Systems Integration;Techniques;Technology;technology intervention;Testing;tool;United States National Institutes of Health;Work

PROJECT_TITLE: Optimizing bilateral and single-sided-deafness cochlear implants for functioning in complex auditory environments

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: KANSAS CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PI_NAMEs: MOSCONI, MATTHEW W;NOLLEN, NICOLE L (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Academy;Acceleration;Address;Advocate;Applications Grants;Awareness;Basic Science;behavioral health;career;career development;Clinical;Clinical Competence;clinical development;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;collaboratory;Communities;Competence;Complement;Contracts;design;Development;Development Plans;diversity and inclusion;Doctor of Philosophy;education evaluation;Educational workshop;Engineering;Enrollment;Ensure;Environment;ethnic diversity;experience;Faculty;Felis catus;Foundations;frontier;Funding;gene environment interaction;Goals;Grant;Healthcare;Human Resources;implementation science;improved;innovation;insight;Institution;Interdisciplinary Study;interest;Journals;Medicine;Mentors;Mentorship;Methodology;Midwestern United States;Minnesota;news;next generation;online course;Patients;peer coaching;peer networks;Physicians;Play;Population;Program Development;programs;Psychology;Public Health Practice;Publications;racial diversity;Records;recruit;Research;research and development;research in practice;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;research to practice;Research Training;Resources;Role;Scholars Program;Science;Scientist;Sexual Health;Site;Taxonomy;Thinking;timeline;tool;Training;Training and Education;Training Programs;Translational Research;United States National Institutes of Health;Universities;Wisconsin;workforce needs

PROJECT_TITLE: Institutional Career Development Core


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The National Institutes of Health (NIH) designated the sexual and gender minority (SGM) communities a health disparity population in late 2016, acknowledging the disproportionate health burdens experienced by individuals who are socially marginalized on the basis of sex, sexual orientation, and gender identity (SSOGI). However, best-practice approaches to collecting demographic data on SSOGI characteristics remain poorly defined and inconsistently used across health care, research, and practice settings, limiting the ability to accurately measure SGM health disparities and presenting a significant barrier to appropriately addressing SGM health needs. As such, the Project Recognize team proposes to use a community-engaged, mixed methods approach to: assess the current state of SSOGI measurement; iteratively develop new SSOGI assessments; test the acceptability of new versus prior measures and investigate their ability to detect the magnitude of SGM health disparities in alcohol use, substance use, and mental health within a large, diverse sample; and leverage existing connections in research, clinical, and federal surveillance settings to support systemic, multi-level advancement in SSOGI data capture.

PI_NAMEs: BEACH, LAUREN BRITTANY;PHILLIPS, GREGORY L. (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: academic review;Address;Adolescent;Adult;Advocacy;Affect;Age;Alcohol consumption;alcohol measurement;Alcohols;Anxiety;asexual;Behavior;Birth;Bisexual;Categories;Characteristics;cisgender;Classification;Clinical;Cognitive;Communities;community engaged research;community engagement;Complex;Data;demographics;Development;Dimensions;Discrimination;Disparity;Dissemination and Implementation;drug of abuse;Drug usage;Effectiveness;effectiveness evaluation;Electronic Health Record;Ensure;Ethnic Origin;Evaluation;Exclusion;experience;Feeling suicidal;Female;flexibility;Focus Groups;Funding;Future;Gays;Gender Identity;gender minority community;gender minority group;gender minority health;gender minority health disparity;gender minority status;gender nonconforming;Grant;Health;Health Care Research;health disparity;health disparity populations;health equity;Health Surveys;Healthcare;Heterosexuals;implementation context;improved;Individual;informant;interest;Intersex;Intervention;Interview;Label;Lesbian Gay Bisexual Transgender;Literature;Live Birth;Location;male;marginalization;marginalized population;Measurement;Measures;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;Minority;minority disparity;minority stress;Monitor;national surveillance;Nature;nonbinary;novel;Outcome;pansexual;Pathway interactions;Patient Care;patient engagement;Performance;Personal Satisfaction;Persons;Pilot Projects;Policies;Population;population health;Population Heterogeneity;practice setting;Prevalence;Process;Provider;Psychometrics;Public Health;Qualitative Methods;queer;Race;Recommendation;Reporting;Research;Research Personnel;research study;same-sex partnership;Sampling;sex;sex assigned;sex disparity;Sex Orientation;Sexual and Gender Minorities;sexual identity;sexual minority;sexual minority group;sexual minority health;social;social stigma;Special Population;Standardization;Stigmatization;stressor;substance use;Surveys;System;Techniques;Testing;therapy development;Time;transgender;Underrepresented Populations;United States National Institutes of Health;usability;Victimization;Voice;Work

PROJECT_TITLE: Project Recognize: Improving Measurement of Alcohol Use and Other Disparities by Sex, Sexual Orientation, and Gender Identity through Community Engagement

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Heart Disease;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The goal of this study is to improve our understanding of the metabolic consequences and cardiovascular risk profiles of women with a history of preterm delivery. We will achieve this by analyzing a wide panel of metabolites among 1500 women in the Nurses' Health Study (NHS) 2 and NHS3, and identifying metabolite profiles and metabolite scores (M-PTD) for women with a history of preterm delivery in NHS2/3, compared to women with term pregnancies. We will examine the association of these M-PTD scores with cardiovascular outcomes in separate populations, as well as formally test mediation of preterm delivery cardiovascular risk by the M-PTD score. Additionally, we will examine the association of different clinical phenotypes of preterm delivery with cardiovascular outcomes. These data will improve our understanding of underlying mechanisms and pathways that contribute to cardiovascular disease risk in women with a history of preterm delivery.

PI_NAMEs: REXRODE, KATHRYN M (contact);RICH-EDWARDS, JANET W

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: adverse pregnancy outcome;Age;Bioinformatics;Biological;Biometry;Blood specimen;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Clinical;clinical phenotype;cohort;Collection;Coronary heart disease;Data;Data Collection;Data Set;Development;Diabetes Mellitus;Disease Outcome;disorder control;disorder risk;Enrollment;epidemiology study;Evaluation;Event;experience;Exposure to;Female;Funding;Future;Goals;high risk;Hyperlipidemia;Hypertension;improved;Incidence;Individual;Infrastructure;Life Cycle Stages;Life Style;liquid chromatography mass spectroscopy;Measures;Mediating;Mediation;Medical;Membrane;men;Metabolic;metabolomics;Methodology;Midlife women;Morbidity - disease rate;mortality;Mothers;Nurses' Health Study;Obesity;Outcome;parous;Participant;Pathway interactions;Phenotype;phenotypic biomarker;Physiological;Population;Pregnancy;Pregnancy Complications;Pregnancy Histories;Premature Birth;Premature Labor;prevent;Prevention strategy;prospective;Public Health;Recording of previous events;recruit;Research;Research Personnel;Risk;Risk Factors;Risk Marker;Risk Reduction;Rupture;Sampling;segregation;Stroke;study population;success;System;Testing;Therapeutic Intervention;Time;Validation;Weight Gain;Woman;Women's Health

PROJECT_TITLE: Using Metabolomics to Understand CVD Risk in Women with a History of Preterm Delivery

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative This project will investigate a previously unknown mechanism of action of Dapsone in Mycobacterium leprae and decipher the strategies evolve by this bacterium to develop resistance. Success in the stated aims of this project will lead to the identification of novel molecular markers of antibiotic resistance in leprosy.

PI_NAMEs: AVANZI, CHARLOTTE  (contact)

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: 4-Aminobenzoic Acid;4-Aminobutyrate aminotransferase;Aldehydes;aminobutyrate;Antibiotic Resistance;Antibiotics;Bacteria;Binding;Biological Assay;Candidate Disease Gene;Carbon;Carboxylic Acids;Cells;Citric Acid Cycle;Clinic;Clinical;clinically relevant;Collection;comparative genomics;Complement component C4a;Development;Dihydropteroate Synthase;Drug Monitoring;Drug resistance;Energy Metabolism;enzyme activity;Enzymes;Exposure to;Fatty Acids;fighting;Folate Biosynthesis Pathway;Folic Acid;Folic Acid Antagonists;Gene Cluster;Gene Combinations;gene function;Genes;Genetic;Genetic Polymorphism;Genome;Genus Mycobacterium;In Vitro;Infection;Knowledge;Lead;Leprosy;Measures;Metabolism;metabolomics;Molecular;molecular marker;Monitor;Mus;Mutation;mycobacterial;Mycobacterium leprae;Mycobacterium marinum;Mycobacterium tuberculosis;nonsynonymous mutation;novel;Orthologous Gene;overexpression;Oxidoreductase;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Predisposition;prevent;Production;Recombinants;Recommendation;Regimen;Resistance;Resistance development;resistance gene;resistance mechanism;Rifampin;Role;Shunt Device;success;Succinates;Sulfonamides;Symptoms;Testing;Treatment Failure;Vaccines;weapons;whole genome;World Health Organization

PROJECT_TITLE: Mechanism of action of Dapsone in Mycobacterium leprae

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Lymphatic Research;Lymphoma;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Project Relevance to Public Health: We propose to evaluate genetic and epigenetic factors for progression to Chronic Lymphocytic Leukemia (CLL) in a large established cohort of Caucasian individuals who have the precursor condition called monoclonal B-cell lymphocytosis (MBL). To address the widening equity gap with respect to our understanding of MBL and progression to CLL in African American populations, we will also develop a newly formed African American cohort of MBLs in order to conduct exploratory analyses of these genetic and epigenetic factors. The results of our study may provide the development of a risk prediction tool that in turn may provide the development of new clinical recommendations for individuals with MBL; it will also provide needed initial data in African Americans with MBL.

PI_NAMEs: BRAGGIO, ESTEBAN ;OAKES, CHRISTOPHER C.;SLAGER, SUSAN L (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: Address;African American;African American population;Age;Aggressive Clinical Course;anxiety reduction;B-Lymphocytes;Biological Markers;biomarker identification;Calibration;Caucasians;Cell Count;Chronic Lymphocytic Leukemia;Classification;Clinical;cohort;Cohort Studies;Data;Development;Discrimination;Disease;disparity gap;Distress;DNA Methylation;Early treatment;Epigenetic Process;Etiology;Evaluation;First Degree Relative;Future;Genes;Genetic;genetic analysis;genetic risk factor;genome wide association study;Genotype;Germ Lines;Goals;high risk;Immune response;Immunophenotyping;Impairment;improved;Individual;Indolent;Infection;infection risk;Inherited;Knowledge;leukemia;Lymphocytosis;Lymphoproliferative Disorders;Malignant - descriptor;Malignant Neoplasms;Methylation;Morbidity - disease rate;mortality;Mutate;Mutation;Patients;Phase;Practice Guidelines;predictive modeling;predictive signature;predictive tools;premalignant;Prevalence;Prevention strategy;progression risk;prospective;Public Health;Quality of life;Recommendation;Reporting;Resources;Risk;Risk Factors;risk prediction;risk stratification;Role;screening;Second Primary Cancers;Single Nucleotide Polymorphism;Somatic Mutation;Susceptibility Gene;targeted sequencing;Techniques;Testing;Time;trend;United States;Work

PROJECT_TITLE: The genetic and epigenetic etiology of progression from the precursor state to chronic lymphocytic leukemia (CLL)

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


PHR: Public Health Narrative We will establish a Diagnostic Center of Excellence focusing on decreasing diagnostic errors in medical imaging by implementing and evaluating a highly resilient system for care planning and coordination, as well as a peer learning system for clinical providers. In addition, we will seek consensus on evidence-based recommendations to enhance diagnosis of four targeted diseases – lung, prostate, pancreas and adrenal cancer. Combined, these initiatives may help reduce delayed, wrong, or missed diagnoses that contribute to poor patient outcomes.

PI_NAMEs: KHORASANI, RAMIN  (contact);LACSON, RONILDA

PROGRAM_OFFICER_NAME: COSBY, KAREN

PROJECT_TITLE: DECODE: Diagnostic Excellence Center on Diagnostic Error


ORG_DEPT: CHEMISTRY

PHR: Structural and functional studies of the terpenoid cyclases show how these novel enzymes generate the largest and most diverse family of natural products found on the Earth. Importantly, many terpenoids exhibit useful medicinal properties, e.g., as antibacterial, antifungal, anti-inflammatory, or anticancer agents. Therefore, understanding and engineering terpenoid cyclase function in generating complex carbon scaffolds will ultimately enable drug discovery at the interface of natural products chemistry, enzymology, structural biology, and synthetic biology.

PI_NAMEs: CHRISTIANSON, DAVID W (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Active Sites;Alcohols;Anabolism;analog;Anti-Bacterial Agents;anti-fungal agents;Anti-Inflammatory Agents;Anti-malarials;Antineoplastic Agents;Antioxidants;Artemisinins;Aspergillus flavus;Binding;Biology;bisphosphonate;Canes;Carbon;Catalysis;catalyst;Catalytic Domain;central nervous system injury;chemical reaction;Chemicals;Chemistry;Chemotherapy-Oncologic Procedure;Complex;Cryoelectron Microscopy;Cyclization;Data;Dimethylallyltranstransferase;drug discovery;Engineering;enhancing factor;ent-kaurene synthetase A;Enzymatic Biochemistry;Enzymes;Evolution;Exhibits;Family;Foundations;Funding;fusicoccin;Gibberellins;Hydroxyl Radical;inhibitor;Investigation;Kinetics;Lead;Length;Life;Link;Malignant Neoplasms;manufacture;Medicine;Molecular;Mutagenesis;Natural product discovery;Natural Products;Natural Products Chemistry;Nature;novel;Paclitaxel;Pathway interactions;Penicillium;peptide synthase;Periodicity;Pharmaceutical Preparations;pharmacologic;Physical condensation;Planet Earth;Property;Protein Engineering;Proteins;Protons;Reaction;reaction rate;Reporting;Research;Roentgen Rays;scaffold;Services;Sesquiterpenes;structural biology;Structure;Structure-Activity Relationship;synthetic biology;terpene synthase;Terpenes;Terpenoid Biosynthesis Pathway;Therapeutic;Time;Water

PROJECT_TITLE: Structure and Function of Biosynthetic Enzymes

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: This training program supports short term research opportunities for University of Michigan medical students. The goal of the program is to expose these students to scientific investigation to promote medical research careers and to promote an understanding of the role of medical research in the practice of medicine.

PI_NAMEs: FLAHERTY, KEVIN R (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Basic Science;Biomedical Research;career;career development;Clinical;Clinical Research;clinical training;clinically relevant;Discipline;Educational Curriculum;Ethics;experience;Faculty;faculty mentor;Fostering;Goals;health care quality;innovation;Institution;Learning;Literature;Medical Research;medical schools;Medical Students;Medicine;meetings;Methodology;Methods;Michigan;National Research Service Awards;next generation;Physicians;Positioning Attribute;programs;Publications;Research;Research Personnel;Research Project Grants;Research Training;responsible research conduct;Running;Schedule;Scientist;Students;summer program;Supervision;Talents;Time;Training Programs;Training Support;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Short Term Biomedical Research Training Program for Students


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative We describe a training program that seeks to identify a group of highly talented predoctoral students to become the next generation of researchers in the neuroscience of aging who will provide significant advances in the understanding and treatment of age-related changes in brain function and age-related neurodegenerative conditions such as Alzheimer's disease. Predoctoral students are offered a flexible, interdisciplinary program of course work, coupled with basic and/or translational research in the neuroscience of aging, to achieve these important goals that will contribute to improved public health.

PI_NAMEs: CASTELLANO, JOSEPH MICHAEL;HOF, PATRICK R (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Aging;Neurosciences;Research Training

PROJECT_TITLE: Research Training in the Neuroscience of Aging


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Lung;Lung Cancer;Precision Medicine

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The promise of molecularly targeted therapy for cancer patients has largely not been realized due to heteroge- neous resistance mechanisms, where targeted monotherapy typically results in short term response not long- term cure. Unraveling the complexities of therapeutic resistance is challenging because it is a complex interplay of drug distribution and target engagement as well as multifaceted and dynamic interactions between the tumor and its microenvironment. We have developed critical new tools (i.e., Therapeutic Response Imaging through Proteomics and Optical Drug Distribution and binding, TRIPODD) to quantify therapeutic efficacy and the corre- sponding resistance mechanisms to aid in crafting effective cancer treatment strategies.

PI_NAMEs: GIBBS, SUMMER LYNNE (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;Antibodies;Bar Codes;Behavior;behavior prediction;Binding;Biological Models;Cancer Model;Cancer Patient;cancer therapy;cancer type;candidate identification;Cell Line;Cell Survival;Cells;Clinical Trials;clinically relevant;Color;combinatorial;Combined Modality Therapy;Complex;curative treatments;Development;Disease;DNA;drug distribution;Drug resistance;drug standard;Drug Targeting;Epidermal Growth Factor Receptor;FDA approved;Flow Cytometry;fluorescence imaging;Future;Genomics;Heterogeneity;Image;imaging agent;imaging platform;Immune;Immunofluorescence Immunologic;improved;In Situ;in vivo;inhibitor therapy;innovation;kinase inhibitor;Label;Malignant Neoplasms;Maps;mathematical model;Measures;MEKs;Modeling;molecular targeted therapies;Monitor;Morphology;Mus;Mutation;mutational status;Nature;Non-Small-Cell Lung Carcinoma;novel;Optics;patient derived xenograft model;Performance;Periodicity;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Plasma;predicting response;prediction algorithm;protein expression;Proteins;Proteome;proteomic signature;Proteomics;Protocols documentation;Reagent;Resistance;resistance mechanism;Resolution;response;Screening procedure;Signal Pathway;Signal Transduction;small molecule therapeutics;Specimen;targeted cancer therapy;Technology;Testing;Therapeutic;therapy outcome;therapy resistant;Tissues;tool;Transgenic Organisms;Treatment Efficacy;Treatment outcome;treatment response;treatment strategy;tumor;tumor growth;tumor heterogeneity;tumor xenograft;Tyrosine Kinase Inhibitor;Validation;Western Blotting;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: A Novel Fluorescence Imaging Platform to Predict Response to Combinatorial Tyrosine Kinase Inhibitors


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Gene Therapy;Genetics;Human Genome;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Transcriptional dysregulation is common characteristic of cells in disease states, but the combinatorial complexity with which non-coding elements and chromatin regulatory proteins interact to determine gene expression makes it difficult to determine how transcriptional dysregulation arises and how it can be therapeutically reversed. In the F99 phase, I improve high- throughput CRISPR methods to accurately link regulatory elements with genes and I develop high-throughput recruitment assays to systematically identify the domains within human chromatin regulators that repress gene expression. In the K00 phase, I propose to develop high- throughput approaches that dissect transcriptional dysregulation in kidney disease.

PI_NAMEs: TYCKO, JOSH  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: advanced disease;Affect;Autosomal Dominant Polycystic Kidney;Award;Binding;Biological Assay;C-terminal;career;Cell membrane;Cell Nucleus;Cell Proliferation;cell type;Cells;Characteristics;Chemicals;Chromatin;chromatin modification;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;CRISPR interference;CRISPR screen;CRISPR/Cas technology;Cyst;Cystic kidney;Cytoplasm;Data;Development;Disease;disease model;disease phenotype;Dissection;DNA;DNA Binding Domain;DNA-Binding Proteins;Elements;Engineering;Enhancers;epigenome;epigenomics;Exhibits;experimental study;Fellowship;Gene Dosage;Gene Expression;gene repression;Gene Silencing;Gene Targeting;gene therapy;gene-targeted therapy;Genes;genetic regulatory protein;Genetic Transcription;Genome;genome-wide;Genomics;Goals;Guide RNA;Health;Heterochromatin;high throughput screening;high throughput technology;Histones;Human;Human Genome;improved;innovation;Integral Membrane Protein;Intracellular translocation;Kidney Diseases;Kidney Failure;Knowledge;Lead;Learning;Libraries;Link;Maps;Measurement;Measures;method development;Methods;Modification;Mutation;Nature;novel;Organoids;Pathway interactions;Patients;Persons;Phase;Phenotype;polycystic kidney disease 1 protein;Postdoctoral Fellow;Prevalence;Process;Proliferating;promoter;Proprotein Convertase 1;protein function;Proteins;Proteome;rational design;recruit;Regulation;Regulatory Element;Reporter;Repression;Research;Research Methodology;Resources;response;Science;Signal Transduction;skills;System;Tail;Techniques;Technology;technology development;Tertiary Protein Structure;Testing;Therapeutic;therapeutic gene;tool;Toxic effect;Training;Transcriptional Regulation;Untranslated RNA;Variant;Work;Writing

PROJECT_TITLE: High-throughput dissection of transcriptional regulation in kidney disease


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

PHR: Project Narrative: Human microbiome plays a critical role in the etiology and progress of many diseases. This proposal explicitly addresses the hidden batches and biases in microbiome sequencing studies, two of the most important challenges that impede our ability to make reproducible and trustworthy microbiome discoveries in large-scale microbiome studies. The proposed methods will be applied to ongoing microbiome studies to gain a better understanding of the complex microbiome-relationship, laying the foundation toward microbiom-informed treatment and prevention strategies.

PI_NAMEs: ZHAO, NI  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Acceleration;Address;Algorithms;analytical method;bacterial community;beta diversity;Birth;Cations;Cells;Characteristics;Clinical Research;Cohort Studies;Collection;Communities;Complex;Computer software;Data;Data Analyses;Data Set;data tools;data visualization;Deposition;design;Detection;detection method;Disease;disorder risk;DNA;epidemiology study;Etiology;Evaluation;experimental study;Failure;Foundations;Genetic Markers;Health;high dimensionality;Human;Human Microbiome;human microbiota;improved;interest;Investigation;metagenomic sequencing;Methods;microbial;microbiome;microbiome analysis;microbiome research;microbiome sequencing;microorganism;Modeling;Morphologic artifacts;New Hampshire;novel;novel strategies;Observational Study;Odds Ratio;open source;Performance;Personal Satisfaction;Phenotype;Phylogenetic Analysis;Play;Prevention strategy;Procedures;Process;Protocols documentation;Public Domains;Reproducibility;Research;Research Personnel;research study;Resistance;Role;Sampling;semiparametric;Shotguns;simulation;Statistical Methods;Structure;Survival Analysis;Taxon;Taxonomy;Testing;Time;tool;transcriptome sequencing;treatment strategy;trustworthiness;user friendly software;vaping;Work

PROJECT_TITLE: Statistical methods for analyzing messy microbiome data: detection of hidden artifacts and robust modeling approaches

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Natural Products;Orphan Drug;Prevention;Rare Diseases

PHR: Narrative This proposal evaluates new supratherapeutic paclitaxel-loaded buttresses for tumor bed implantation to reduce locoregional recurrence rates after resection of retroperitoneal, non-GIST abdominal, and pelvic sarcomas. The current standard of care is multivisceral resection, and adjuvant therapies including radiotherapy, single-dose hyperthermic intraperitoneal chemotherapy, and systemic chemotherapy fail to improve patient outcomes. This proposed approach has the potential to reduce tumor recurrence and extend survival via local application of high-dose adjuvant chemotherapeutics at the time of resection.

PI_NAMEs: COLSON, YOLONDA L;GRINSTAFF, MARK W.;RAUT, CHANDRAJIT PREMANAND (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Abdomen;Address;Adjuvant;Adjuvant Therapy;Anatomy;Animal Model;Animals;Antineoplastic Agents;aqueous;Beds;Binding;Biodistribution;biomaterial compatibility;Biomedical Engineering;biomedical referral center;caprolactone;Carbon Dioxide;Carbonates;Cell Cycle Kinetics;Cell Death;chemotherapy;Clinical;Collaborations;Colon Carcinoma;cytotoxicity;Data;Death Rate;Development;Disease;Distant;Dose;Drug Delivery Systems;Drug Kinetics;efficacy evaluation;esterase;Excision;experience;Experimental Designs;experimental study;Failure;Film;flexibility;Glycerol;healing;Histologic;Hour;Hydrolysis;Hyperthermia;Implant;implantation;improved;In Vitro;in vivo;Incidence;innovation;intraperitoneal therapy;intravenous administration;Invaded;Kidney;Kinetics;Microscopic;Modeling;mortality;mouse model;Mus;Non-Small-Cell Lung Carcinoma;novel strategies;Operative Surgical Procedures;Organ Preservation;Paclitaxel;Pathology;patient derived xenograft model;Patient imaging;Patient-Focused Outcomes;Patients;Pattern;Pelvis;Perioperative;perioperative morbidity;Pharmaceutical Preparations;Phase;Polymers;pre-clinical;prevent;Prevention;Radiation therapy;Recurrence;Recurrent tumor;Reporting;Resected;Residual state;Retroperitoneal Sarcoma;Retroperitoneal Space;Risk;safety assessment;Sarcoma;side effect;Site;Soft tissue sarcoma;Solubility;standard of care;Structure;Succinic Acids;Surface;Surgical margins;Surgical Models;Surgical sutures;Survival Rate;systemic toxicity;Testing;Therapeutic;Time;Tissues;tumor;Tumor Burden;Tumor Debulking;Visceral;X-Ray Computed Tomography

PROJECT_TITLE: Supratherapeutic PTX Buttresses Reduce Locoregional Recurrence Rates Following Surgery for Soft Tissue Sarcomas

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Obesity is a significant risk factor for various health conditions, including metabolic syndrome, cardiovascular disease, and type 2 diabetes; several classes of prescription medication, including second generation antipsychotics (SGAs), increase obesity risk by disrupting the gut microbial community. This project focuses on microbiome shifts caused by risperidone, an SGA that causes weight gain, and reutericyclin, a specialized microbial metabolite that deflects risperidone-induced weight gain. Our findings will reveal how xenobiotic- mediated induction of bacteriophages can lead to shifts in energy flux and will inform the development of phage-targeted therapeutic strategies against the development of obesity in individuals taking prescription medications.

PI_NAMEs: KAZEN, ALEXIS B (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: 16S ribosomal RNA sequencing;Animals;antimicrobial;Antipsychotic Agents;autistic;Bacteria;Bacterial Genome;Bacteriophages;Basal metabolic rate;Binding;Bioinformatics;biomarker identification;Biomedical Research;biomedical scientist;Cardiovascular Diseases;comorbidity;comparison control;Control Animal;Data;design;Development;DNA;Drug Prescriptions;energy balance;Environment;Etiology;experimental study;Feces;Future;Gene Expression Profiling;Generations;Goals;Growth;gut bacteria;gut microbiome;gut microbiota;Health;Homeostasis;Immunology;Individual;Knowledge;Laboratories;Lactobacillus reuteri;Machine Learning;Mediating;Mediator;medical schools;Metabolic;Metabolic syndrome;metagenomic sequencing;microbial;Microbiology;microbiome;microbiome analysis;microbiome composition;microbiome therapeutics;model organism;Molecular;Monitor;Mus;mutant;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity development;obesity risk;obesogenic;Organism;Parents;particle;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Play;Positioning Attribute;prevent;Production;Property;Public Health;Research;response;reutericyclin;Risk;Risk Factors;Risperidone;Role;SOS Response;stressor;Supplementation;Syndrome;targeted treatment;Testing;Therapeutic;Thinness;Time;Training;treatment group;Viral;Weight;Weight Gain;Wisconsin;Woman;Work;Xenobiotics

PROJECT_TITLE: Investigating how xenobiotics interact with phages to shift energy balance


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Lung;Pediatric;Prevention;Sleep Research

PHR: PROJECT NARRATIVE Obstructive sleep apnea is common in children and most often treated by adenotonsillectomy, but after surgery the condition may persist, which can lead to neurocognitive and cardiovascular morbidity and increased healthcare utilization. Drug-induced sleep endoscopy (DISE) is a sedated, fiber-optic assessment of the upper airway that can direct individualized surgical treatment in children with sleep apnea. This research will help to determine the ideal anesthetic protocol for DISE in children, and whether the information gained from DISE prior to adenotonsillectomy can help predict post-operative outcomes.

PI_NAMEs: KIRKHAM, ERIN MARIE (contact)

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: Adenoidal structure;Adoption;Affect;aged;airway obstruction;Anatomy;Anesthetics;Behavior;behavior rating scale;Behavioral;Black race;Blinded;cardiovascular health;Cardiovascular system;career;Child;Childhood;Clinical;Clinical Investigator;Clinical Trials;Cognitive;Consensus;Data;design;Development;Dexmedetomidine;Diagnostic;Drug usage;Endoscopy;Equipment and supply inventories;experience;Fiber Optics;flexibility;Frequencies;Functional disorder;Funding;Goals;Guidelines;health care service utilization;improved;improved outcome;Individual;International;Intervention;Intravenous;Knowledge;Left;Legal patent;malignant supraglottis tumor;Measurement;Measures;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentorship;Morbidity - disease rate;National Heart, Lung, and Blood Institute;Neurocognitive;neuromuscular;Obesity;Obstruction;Obstructive Sleep Apnea;Operative Surgical Procedures;Otolaryngologist;Outcome;Outcome Measure;outcome prediction;Oxygen;Patient Selection;Pattern;Pharmaceutical Preparations;Physiological;Polysomnography;Population;Positioning Attribute;Postoperative Period;Predictive Value;Predictive Value of Tests;primary endpoint;Procedures;Propofol;prospective;Protocols documentation;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;Regimen;Research;Research Personnel;Research Training;Residual state;Resources;respiratory;Respondent;Risk;Risk Factors;Sampling;secondary endpoint;Sedation procedure;sedative;Series;Severities;Site;skills;Sleep;Sleep Apnea Syndromes;Soft Palate;Specificity;Standardization;surgery outcome;Surveys;Symptoms;Testing;Time;tongue root;Tonsil;Training;Translating;treatment as usual;Treatment outcome;trial comparing;Ventilatory Depression

PROJECT_TITLE: Optimization of Surgical Treatment for Pediatric Obstructive Sleep Apnea

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Prevention;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The ColoCare Study is a cohort of recently diagnosed patients with colorectal cancer (stage I-IV) that utilizes standardized protocols for longitudinally collecting participant questionnaires, biospecimens, medical record data, and clinical and patient-reported outcomes. Over 3,000 demographically and geographically diverse participants have been recruited (with a median follow-up time of 2.1 years, contributing >8,000 questionnaires and >17,000 biospecimens), and ColoCare data and/or biospecimens have supported 79 projects involving 72 external investigators (19 projects led by external investigators and 49 from early stage investigators and trainees). In this renewal, we will extend follow-up through 5 years post-diagnosis; prioritize recruitment of patients from underserved/understudied populations and with early-onset colorectal cancer; continue repeat ascertainment of self-reported data (including patient-reported outcomes) and blood samples; and enhance our centralized data repository and biobank to support data sharing and research that will improve colorectal cancer treatment, survivorship, and clinical outcomes.

PI_NAMEs: BYRD, DORATHA ARMENTHUS;FIGUEIREDO, JANE C.;GIGIC, BILJANA ;SHIBATA, DAVID ;TORIOLA, ADETUNJI T;ULRICH, CORNELIA M (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Acceleration;Address;Ancillary Study;anti-cancer research;Behavioral;biobank;Biological Markers;Blood;Blood specimen;blood-based biomarker;cancer health disparity;Cancer Prognosis;Cancer Survivorship;Cessation of life;Clinical;Clinical Data;cohort;Cohort Studies;Collaborations;Collection;colon cancer patients;Colorectal Cancer;colorectal cancer treatment;Communities;community advisory board;Data;data harmonization;Data Reporting;data repository;data sharing;data warehouse;Decision Making;design;Development;Diagnosis;Disparity;early onset colorectal cancer;Enrollment;Epidemic;epidemiologic data;ethnic minority;Ethnic Origin;experience;Feces;follow-up;Geography;Grant;gut microbiome;improved;indexing;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Intervention;Knowledge;Life Style;Maintenance;Malignant Neoplasms;Medical;Medical Records;men;microbiome;Modality;Molecular;neoplasm registry;neoplasm resource;new therapeutic target;Newly Diagnosed;novel;novel marker;novel therapeutics;Outcome;Paper;Participant;patient engagement;Patient Outcomes Assessments;Patient Participation;patient population;Patient Recruitments;Patient Self-Report;Patients;Population;Population Heterogeneity;Productivity;Prognosis;prospective;Protocols documentation;Publishing;Questionnaires;Race;racial diversity;racial minority;recruit;Rectal Cancer;Recurrence;Research;Research Personnel;Resources;Risk;Rural Population;sample collection;Sample Size;Sampling;Science;Scientific Advances and Accomplishments;Secure;Site;Standardization;stem;stool sample;survivorship;Time;Tissue Sample;translational study;Tumor Tissue;Underserved Population;Urine;Woman;Work

PROJECT_TITLE: Transdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare Study


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Prevention;Primary Health Care

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative Numerous studies have demonstrated that TBC is an evidence-based strategy for improving blood pressure (BP) management and control, but primary care practices experience significant barriers to implementing TBC care processes, particularly in small-medium size independent primary care practices. The objective of this study is to compare the effectiveness of PF on the adoption of core TBC components, centered on improving BP management and outcomes in SIPs, to usual care. Identifying strategies that increase the adoption of TBC are important to address the high burden of hypertension in the US, a leading risk factor for cardiovascular disease.

PI_NAMEs: SHELLEY, DONNA R (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Address;Adopted;Adoption;Adult;Advisory Committees;Ambulatory Care;blood pressure control;blood pressure elevation;Cardiovascular Diseases;cardiovascular risk factor;care coordination;care delivery;Caring;Chronic Disease;Communication;compare effectiveness;comparison intervention;Complex;Consolidated Framework for Implementation Research;Continuity of Patient Care;Data Collection;data warehouse;Death Rate;Decision Making;design;Disease Management;Disease Outcome;Effectiveness;Ethnic Origin;evidence base;Evidence based intervention;Evidence based practice;experience;forging;formative assessment;Funding;Group Practice;Guidelines;Health;health equity;health information technology;Health Personnel;Health Services;Health system;Hypertension;hypertension control;implementation facilitation;implementation strategy;improved;Inequity;Infrastructure;Literature;medication compliance;Mental Health;Methods;Modeling;modifiable risk;mortality disparity;New York City;Outcome;Patient Noncompliance;Perception;Pharmaceutical Preparations;Phase;Population;practice-based research network;Premature Mortality;primary care practice;primary care setting;primary outcome;Process;Protocols documentation;Public Health;Race;Randomized, Controlled Trials;Recommendation;recruit;Research;Resources;routine practice;secondary outcome;Self Management;Site;System;systematic review;team-based care;treatment as usual;United States National Institutes of Health;Work

PROJECT_TITLE: Facilitation of Team-based Care to Improve HTN Management and Outcomes


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: We seek to understand whether the observed racial disparities in monoclonal gammopathy of undetermined significance (MGUS), the precursor to multiple myeloma, may be explained by differences in underlying immune alterations and B-cell activation as well as lifestyle factors such as obesity, diabetes, and use of anti-inflammatory medications between racial/ethnic groups. To address these research questions, we will conduct an epidemiologic study among four racially/ethnically diverse cohorts with available archived serum specimens for exposure and outcome assessment. Findings from this study will provide critical information on the determinants of the racial/ethnic disparity in MGUS.

PI_NAMEs: BERTRAND, KIMBERLY A.;COZEN, WENDY  (contact);DESAI, PINKAL

PROGRAM_OFFICER_NAME: STARKS, VAURICE

PROJECT_TERMS: Activated B-Lymphocyte;Address;adiponectin;Affect;Age;Aging;angiogenesis;Angiogenic Factor;Anti-Inflammatory Agents;Antibodies;Antigens;Archives;Asian;Asian Americans;Asian population;Aspirin;B cell differentiation;B-Cell Activation;B-Lymphocytes;Benign;Biological Assay;Biological Markers;Black American;Black Populations;Black race;black women;Body mass index;cancer epidemiology;cancer health disparity;caucasian American;cell growth;Cell secretion;chemokine;Chlamydia trachomatis;Chronic;chronic infection;cohort;Cohort Studies;Collaborations;Communities;CXCL10 gene;CXCL13 gene;CXCR3 gene;cytokine;Data;Development;Diabetes Mellitus;Disparity;Epidemiology;epidemiology study;ethnic difference;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnic Population;Exercise;experience;Family;Female;Goals;Growth;Growth Factor;Helicobacter pylori;Hematologic Neoplasms;Hepatitis B Virus;Hepatitis C virus;Hispanic;Hispanic Populations;Human Papillomavirus;IL17 gene;IL6 gene;IL6ST gene;Immune;Immune response;Immunologic Markers;Immunologic Stimulation;Incidence;Individual;Infection;Infectious Agent;Inflammation;Interleukin-10;Knowledge;Laboratories;Latino;Life Style;lifestyle factors;Logistic Regressions;male;Malignant Neoplasms;Measures;Medical Records;Memory;Metformin;microbial;Monoclonal gammopathy of uncertain significance;multi-ethnic;multidisciplinary;Multiple Myeloma;neoplasm registry;Nested Case-Control Study;Not Hispanic or Latino;Obesity;Outcome Assessment;Participant;Pharmaceutical Preparations;Physical activity;Plasma Cells;Population;Positioning Attribute;Prevalence;Prevention;Preventive;progression risk;Proteins;Race;racial determinant;racial difference;racial disparity;racial diversity;racial population;Relative Risks;Reporting;Research;Research Personnel;response;Risk;Risk Factors;Role;Sampling;screening;Serum;sex;Signal Transduction;Specimen;Stromal Cell-Derived Factor 1;System;Techniques;Toxoplasma gondii;Treponema pallidum;Variant;Virus;Women's Health

PROJECT_TITLE: Determinants of the racial/ethnic disparity in MGUS risk: An epidemiologic study in 4 cohorts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The Metabolic Dysregulation and Cancer Risk Consortium (MDCRC) is being created to study the biologic mechanisms by which obesity increases the risk of cancer in humans and will bring together several research groups studying how obesity alters normal metabolic pathways leading to cancer risk. The Consortium members will work together to identify common areas of data collection, and develop of a harmonized data set to accelerate research and discovery. The MDCRC Coordinating Center will facilitate the creation of this rich research data set, as well as provide both scientific leadership and project management for the collaborative cross-Consortium activities.

PI_NAMEs: DIPIETRO, LORETTA ;TEMPROSA, MARINELLA  (contact)

PROGRAM_OFFICER_NAME: LAM, TRAM K

PROJECT_TERMS: Acceleration;Adolescent;Affect;Agreement;archive data;Area;Bioinformatics;Biological;Biological Process;Biometry;Body Composition;cancer initiation;cancer prevention;cancer risk;cancer type;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Communication;comparative effectiveness study;Complications of Diabetes Mellitus;Computational Biology;Data;Data Analyses;data archive;Data Collection;data harmonization;data infrastructure;data management;data platform;Data Reporting;data repository;data resource;Data Set;data sharing;Department chair;design;Development;diabetes control;Diabetes Mellitus;diabetes prevention program;editorial;Ensure;Epidemiology;Etiology;Event;Exercise;experience;Faculty;flexibility;Fostering;Future;Goals;Grant Review;Human;Individual;Information Dissemination;Information Systems;innovation;Institution;insulin secretion;Intervention;Journals;Lead;Leadership;Link;Logistics;Manuals;Maternal-Fetal Medicine Units Network;Measurement;Measures;meetings;member;Metabolic;Metabolic Pathway;Metabolism;Methods;Molecular;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Obesity;obesity prevention;operation;Outcome Study;Output;outreach;Pathway interactions;Pilot Projects;Policies;Prevention strategy;Privatization;programs;Protocols documentation;Public Health Schools;Qualifying;Recording of previous events;Reporting;Research;Research Personnel;research study;Resources;Science;scientific hub;Self Correction;Self-Examination;Signal Transduction;Site;skills;success;System;Training;Universities;Washington;web site;Work;working group;Youth

PROJECT_TITLE: Metabolic Dysregulation and Cancer Risk Program: Coordinating Center


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Project Narrative The ubiquitin E3 ligase ITCH plays essential roles in immune response, while its role in tumorigenesis is less understood. The goal of this proposal is to characterize both the melanoma cell-autonomous and non- autonomous functions of ITCH using in vitro and in vivo melanomagenesis models.

PI_NAMEs: WAN, LIXIN  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Adopted;Autoimmune;Binding;Biochemical;Bioinformatics;Biology;BRAF gene;Cell Culture Techniques;cell growth;Cell Physiology;Cell Proliferation;Cells;Communication;cytokine;Data;Development;Ectopic Expression;Exhibits;fitness;Fostering;Future;Genetically Engineered Mouse;Germ Lines;Goals;Human;Hyperactivity;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immune system;Immunology;immunoregulation;Immunosuppression;Immunotherapy;In Vitro;in vivo;Inflammatory;inhibitor;insight;Invaded;Investigation;JNK-activating protein kinase;knock-down;Knockout Mice;Knowledge;Leucocytic infiltrate;Link;Malignant Neoplasms;MAP Kinase Gene;MEK inhibition;MEKs;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;melanomagenesis;migration;Modeling;Molecular Conformation;mouse model;Mus;mutant;N-terminal;Nature;neoplastic cell;novel strategies;Oncogenic;Pathologic;Pathway interactions;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Play;Polyubiquitin;Process;Proliferating;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Proteomics;Pruritus;Publications;Reader;Reporting;Research;Resistance;restraint;Role;Signal Transduction;Testing;Therapeutic;Transforming Growth Factor beta;tumor;tumor-immune system interactions;tumorigenesis;tumorigenic;ubiquitin-protein ligase;Ubiquitination;upstream kinase;Xenograft procedure;Yin

PROJECT_TITLE: Characterizing oncogenic function of ITCH in melanoma

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The catalytic fixation of nitrogen to ammonia is foundational to modern society, enabling adequate fertilizer production to feed billions of people; however, the analogous catalytic transformation of N2 into amines, a highly prized motif in pharmaceuticals, through nitrogen–carbon bond formation has not been realized. New insights into proton-coupled electron transfer (PCET) pathways for N2 reduction, combined with a renaissance in methods for the generation of organic radicals, offer the potential for an efficient synthesis of a wide range of amines. The goal of this proposal is to develop orthogonal approaches to N2 coupling with organic substrates driven by a PCET mediator, providing a fundamental understanding of bond-forming processes in N2 functionalization and access to a diverse set of medicinally relevant compounds.

PI_NAMEs: OVIAN, JOHN MICHAEL (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Active Sites;Alkenes;Alkylation;Amines;Ammonia;Atmosphere;Carbon;catalyst;chemical synthesis;Chemicals;Complex;Coupled;Coupling;design;Development;Electron Spin Resonance Spectroscopy;Electron Transport;experimental study;Fertilizers;Foundations;functional group;Generations;Glean;Goals;Health;High temperature of physical object;improved;Industrialization;innovation;insight;Intercept;Iron;Kinetics;Ligands;Mediator;Medicine;metallicity;metallocene;Metals;Methods;Modernization;National Institute of General Medical Sciences;Nature;Nitrogen;Nitrogen Fixation;Nitrogenase;novel strategies;Pathway interactions;Periodicity;Persons;Pharmacologic Substance;pressure;Procedures;Process;Production;Protons;Reaction;Renaissance;Research;sample fixation;scaffold;Silicon;small molecule;Societies;Source;Structure;success;Techniques;ultraviolet irradiation;Validation;X-Ray Crystallography

PROJECT_TITLE: An Electrochemical Approach to Amine Synthesis from Nitrogen