ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Chemotherapy-induced neuropathy (CIN)—pain, numbness, and/or tingling distributed in the hands and feet— produces persistent symptoms affecting sensation and balance in cancer survivors. Up to 50% of cancer survivors still suffer from CIN 6 years after treatment, with a 1.8-fold increased risk of falls which negatively impacts quality of life. We propose to test auricular point acupressure (APA)—a non-invasive and nonpharmacological patient managed strategy—as an innovative solution for CIN.

PI_NAMEs: JOHNSON, CONSTANCE MARGARET (contact);LUKKAHATAI, NADA

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: active method;Acupressure;Acupuncture Therapy;Adherence;Affect;afferent nerve;Aftercare;American Society of Clinical Oncology;Analgesics;Anti-Inflammatory Agents;Basal Ganglia;Biological Markers;Bortezomib;Brain;Cancer Patient;Cancer Survivor;cancer therapy;Cells;Characteristics;chemotherapy;chemotherapy induced neuropathy;China;Clinical;Clinical Trials;cognitive control;cytokine;Data;Demographic Factors;design;Dose;duloxetine;Ear;Ear Acupuncture;Ecological momentary assessment;effective therapy;efficacy evaluation;Equilibrium;Esthesia;Ethnic Origin;Europe;executive function;Exercise;expectation;experience;fall risk;Fatigue;Fingers;foot;functional disability;Functional disorder;Functional Magnetic Resonance Imaging;Gender;Goals;Hand;Health Care Costs;Image;improved;indexing;Inflammation;Inflammatory;innovation;Interferon Type II;Interleukin-1 beta;Interleukin-2;Interleukin-6;Intervention;Late Effects;Licensing;Macrophage;Malignant Neoplasms;Measures;Mediating;Monitor;morphine equivalent;Needles;neuroimaging;Neurons;Numbness;Opioid;opioid overuse;opioid use;Outcome;Pain;pain inhibition;Pain management;pain perception;pain relief;Pain Threshold;Participant;Patient Self-Report;Patients;Peripheral Nervous System;persistent symptom;Pharmaceutical Preparations;Physical Function;Placebo Effect;Placebos;Plasma;Platinum;primary endpoint;primary outcome;Provider;Psychophysics;Quality of life;Race;Randomized, Controlled Trials;Recommendation;Regulation;Reporting;Resources;secondary outcome;Self Management;Sensory;Sensory Thresholds;Severities;sex;side effect;Signal Transduction;skills;Sleep;smartphone application;Specificity;Stimulus;Survival Rate;Symptoms;Taiwan;taxane;Testing;Time;TNF gene;Toes;tool;treatment as usual;Vinca Alkaloids

PROJECT_TITLE: Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: COLUMBIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Autism spectrum disorder (ASD) and Attention-Deficit/Hyperactivity Disorder are two of the most common neurodevelopmental disorders and have a surprisingly high rate of comorbidity of up to 70%. Features in early infancy have been associated with both ASD and ADHD diagnoses, such as social communication deficits, atypical attention processes, and motor skill challenges, but understanding of the transdiagnostic and differential features of these disorders is limited. This study will investigate the association between social communication, attention, and motor skills in infancy and symptoms of ASD and ADHD to elucidate early mechanisms underlying the development of these disorders.

PI_NAMEs: FEDERICO, ALEXIS  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 3 year old;Address;Affect;Age Months;associated symptom;Attention;Attention deficit hyperactivity disorder;Attentional deficit;autism biomarker;autism spectrum disorder;autism symptoms;behavior measurement;Behavioral;Child;Childhood;clinically significant;Communication;Communication impairment;comorbidity;comparison group;Complex;Development;Diagnosis;Diagnostic;diagnostic criteria;Dimensions;Disease;Early Diagnosis;Early identification;Early Intervention;Etiology;Face;Family;Family history of;Genetic;Genetic Risk;Heart Rate;high risk;improved;infancy;Infant;Intervention;Investigation;Life;Light;Link;Literature;longitudinal design;Maps;Measures;Mental disorders;Motor;motor deficit;Motor Skills;National Institute of Mental Health;Neurodevelopmental Disorder;novel;Outcome;Pathway interactions;Phenotype;Physiological;Process;prospective;reduce symptoms;Research;Research Domain Criteria;Research Personnel;Screening procedure;Severities;skills;social;social communication;Specific qualifier value;Specificity;Stimulus;sustained attention;Symptoms;Time

PROJECT_TITLE: Infant Predictors of ADHD and ASD Symptomology


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: Cutaneous wounds create significant health problems for Veterans, including wartime trauma, diabetic foot ulcers, and pressure ulcers. More than 100 million new skin wounds appear annually on patients, and most skin wounds heal with a fibrotic scar. Scars themselves may also cause severe emotional distress, skin tightening, and physical disability. Although many products are marketed for scar prevention or removal, their results are modest. We aim to develop new therapeutic approaches to tissue repair based upon a deep understanding of the molecular mechanism and a firm commitment to the clinical/translational mission. In our preliminary data, we discovered that the deletion of a cell surface receptor increases the efficiency to induce scarless wound healing in mouse skin. We will dissect molecularly how this receptor regulates scarless wound healing and test whether blocking this receptor also promotes scarless wound healing in human skin.

PI_NAMEs: LEUNG, THOMAS H. (contact)

PROJECT_TERMS: aged;Architecture;Cell Surface Receptors;cell type;Cells;Cicatrix;Clinical;Clinical Trials;comparison control;Data;Data Set;decubitus ulcer;Diabetic Foot Ulcer;Ear;emotional distress;Excision;Exhibits;Foundations;Frequencies;Funding;Future;Genetic;Goals;healing;Health;Human;Imiquimod;Immune;immunodeficiency;improved;Infrastructure;inhibitor;injured;Injury;Joints;Ligands;Mammals;Marketing;Mediating;Modeling;Molecular;Morbidity - disease rate;mouse genetics;Mouse Strains;Mus;Natural regeneration;Neurons;novel therapeutic intervention;old mice;Operative Surgical Procedures;Pathway interactions;Patients;pharmacologic;Phenotype;physically handicapped;pre-clinical;Prevention;receptor;receptor-mediated signaling;recruit;Research Personnel;Resources;Sampling;Signal Pathway;single-cell RNA sequencing;Site;Skin;skin healing;Skin injury;skin wound;Skin wound healing;skin xenograft;small molecule;Speed;Stromal Cell-Derived Factor 1;synergism;Testing;Time;tissue regeneration;tissue repair;Tissues;transcriptomics;Translating;translational goal;Trauma;Veterans;Work;wound;wound closure;wound healing

PROJECT_TITLE: Immune and genetic controls of tissue regeneration in mice and humans

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: IOWA CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative: There is growing evidence that disruptions in redox biology and oxidative stress mediated by oxygen free radicals (as well as other reactive oxygen and nitrogen species) are causally involved in initiation, growth, invasion, metastasis, and treatment of cancer. Free Radical Biology also has strong mechanistic links to radiation biology, cancer biology, inflammation, and degenerative diseases associated with aging. Given the rapidly expanding importance of these concepts in translational biomedical research, the unique Training Program in Free Radical and Radiation Biology meets a national need for scientists to develop novel mechanism based approaches to reduce the health effects of cancer and educate the next generation of leaders in this field that spans both basic and translational science.

PI_NAMEs: SPITZ, DOUGLAS ROBERT (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: CIUDAD DE BUENOS AIRES

ORG_COUNTRY: ARGENTINA

ORG_FIPS: AR

ORG_NAME: UBATEC S.A.

PHR: PROJECT NARRATIVE Antimicrobial resistance is one of the most pressing public health crises of the 21st century. Carbapenem-hydrolyzing -lactamases are a particularly concerning resistance mechanism to our last line antibiotics, the carbapenems. The proposed research on antimicrobial resistance in environmental microorganisms will inform physicians of potential novel -lactamases that may threaten human health before their emergence in the clinic, which is entirely in line with the mission of the NIH and NIAID.

PI_NAMEs: POWER, PABLO  (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Alaska;Alaskan;Antarctica;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Attention;Bacteria;beta-Lactam Resistance;beta-Lactamase;beta-Lactams;Biochemical;Biological;Biological Assay;carbapenem resistance;carbapenemase;Carbapenems;Classification;Clinic;Clinical;Cloning;Collection;Crystallization;Early Diagnosis;Environment;enzyme pathway;Enzymes;Evolution;Exhibits;Exposure to;Frequencies;Fright;Genes;Genetic;Health;Hospitals;Human;insight;Kinetics;Lactamase;Mediating;member;metagenome;Metagenomics;Methods;microorganism;Mission;Molecular;Mutagenesis;Mutation;Names;National Institute of Allergy and Infectious Disease;Natural Selections;Nature;novel;pathogen;pathogenic bacteria;Phenotype;Physicians;Process;Production;Proteins;Public Health;recruit;remote location;repository;Research;Resistance;resistance mechanism;Risk;Role;Route;Sampling;screening;Site-Directed Mutagenesis;Soil;soil sampling;Source;Spectrophotometry;Structure;System;Techniques;trend;United States National Institutes of Health;Variant;X ray diffraction analysis

PROJECT_TITLE: Characterizing novel Beta-lactamases from metagenomic samples: insights into the evolution of antimicrobial resistance from the environment towards human-associated pathogens

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative (3 sentence limit) In mouse genetic models of Down syndrome (DS), enhanced inhibitory efficiency limits hippocampal synaptic plasticity thus negatively affecting cognition. Here we hypothesized that these changes occur during early postnatal periods as a compensatory reaction to excessive neuronal hyperpolarization, caused by increased signaling through Kir3.2 channels, preventing neonatal neurons from “seeing” each other during the formation of nascent neural circuits. While testing this hypothesis, we will examine the therapeutic potential of antagonists of the GABAB receptors as cognitive enhancers in DS.

PI_NAMEs: KLESCHEVNIKOV, ALEXANDER M (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: adenovirus mediated delivery;Adult;Affect;Aftercare;antagonist;Biochemical;Brain;Cognition;Cognitive;Data;Development;disability;Dose;Down's Syndrome;Electrophysiology (science);Excision;G protein-coupled inwardly-rectifying potassium channel;gamma-Aminobutyric Acid;Generations;Genes;Genetic;Genetic Models;Glutamates;Goals;Hippocampus;Impaired cognition;improved;inhibitor;Intraperitoneal Injections;Intraventricular;Mediating;Membrane Potentials;Modeling;Monitor;mouse genetics;mouse model;mouse Ts65Dn;Mus;Neonatal;neural circuit;neuromechanism;Neurons;neurotransmission;Nootropic Agents;Pathway interactions;postnatal;postnatal development;postnatal period;Potassium Channel;pre-clinical;prevent;Property;protein distribution;Reaction;receptor;Resistance;Rest;Role;Signal Transduction;Small Interfering RNA;Synapses;Synaptic plasticity;Synaptic Transmission;synaptogenesis;Techniques;Testing;Therapeutic;therapy development;Time;treatment effect

PROJECT_TITLE: Preventing cognitive impairment in mouse genetic models of Down syndrome by early postnatal suppression of Kir3.2 channel signaling

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative HIV-1 initiates infection by fusing with cell membranes through a process mediated by the viral envelope glycoprotein. Several host factors incorporate into virions and inhibit their fusion with new target cells through a poorly understood mechanism. We will use a panel of cutting-edge imaging techniques to delineate the mechanism by which these host proteins disfavor HIV-1 fusion and to inform new antiviral strategies.

PI_NAMEs: MELIKIAN, GREGORY B (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Actins;Architecture;Attenuated;Binding;Biological Assay;Biophysics;CCR5 gene;Cell fusion;Cell membrane;Cell surface;Cells;comparison control;Complement;Cryoelectron Microscopy;CXCR4 gene;Data;env Glycoproteins;Fluorescence;Foundations;Glycoproteins;Goals;HIV Envelope Protein gp120;HIV resistance;HIV-1;imaging approach;Imaging Techniques;In Vitro;Infection;insight;Integration Host Factors;Interferons;Lateral;Lipids;Maps;Mediating;Membrane;Membrane Fusion;Membrane Lipids;Membrane Proteins;Modeling;Molecular;mutant;Mutation;mutation screening;particle;Process;Property;Protein Family;Proteins;receptor;Receptor Signaling;Reporting;Resistance;response;Role;Serine;Signal Transduction;single molecule;Site;Specificity;Structure;superresolution imaging;superresolution microscopy;Techniques;Tertiary Protein Structure;Testing;Transmembrane Domain;V3 Loop;Viral;Viral Physiology;Viral Proteins;Virion;Virus;Visualization

PROJECT_TITLE: Biophysics of Protein-Mediated Membrane Fusion

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Genetics;Lung

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE In this proposal, we will test the central hypothesis that an upregulation of the B cell immune compartment in lung and blood correlates with the extent of emphysema in COPD independently of the severity of airflow limitation. We will use immunostaining and image mass cytometry techniques, next-generation sequencing with a single-cell approach, in vitro and ex vivo approaches to test our hypothesis that changes in the B cell transcriptomics are associated with an upregulation of the B cell pool in both blood and lung of COPD patients, contributing to lung tissue destruction and emphysema. The successful completion of these studies will help define the clinical phenotype (likely emphysema) that could benefit from therapies targeting B cells or B cell products, leading to earlier and more personalized therapeutic intervention which will greatly alleviate the burden of COPD.

PI_NAMEs: POLVERINO, FRANCESCA  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Airway Disease;airway obstruction;Antigens;Area;B cell therapy;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Biological Assay;Biological Markers;Blood;Blood specimen;Blood Tests;Cell Physiology;Cells;Chronic Obstructive Pulmonary Disease;cigarette smoke;circulating biomarkers;Classification;clinical phenotype;Clonality;cohort;Correlation Studies;Cytometry;Data;Disease Progression;DNA;enzyme linked immunospot assay;Enzyme-Linked Immunosorbent Assay;epigenetic silencing;Flow Cytometry;Freezing;Future;Gene Expression Profile;Gene Rearrangement;Genes;Genetic Transcription;Homeostasis;Image;Immune;Immune response;Immunoglobulin G;Immunoglobulin Isotypes;Immunoglobulins;In Vitro;in vitro Assay;laser capture microdissection;Lobar;Lobe;Lung;lung lobe;Lymphoid Follicle;Mass Spectrum Analysis;Measures;Modification;Molecular Profiling;Nature;next generation sequencing;novel;novel therapeutics;Patients;peripheral blood;personalized therapeutic;Phenotype;Plasma;posttranscriptional;precision medicine;Process;Production;Proliferating;Pulmonary Emphysema;pulmonary function;response;Sampling;Scanning;Severities;Severity of illness;single nucleus RNA-sequencing;single-cell RNA sequencing;Specimen;Structure of parenchyma of lung;tandem mass spectrometry;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;transcriptome;transcriptomics;Up-Regulation;X-Ray Computed Tomography

PROJECT_TITLE: B cell-adaptive Immune Profile in Emphysema-predominant COPD

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project narrative Currently, the factors that determine the effectiveness of chemotherapy for AML are poorly understood. We recently discovered that some Normal Karyotype AML patients, who had very long first remissions with chemotherapy alone, had unexpectedly high frequency of pathogenic MYC mutations in the dominant leukemia clone at diagnosis. In this proposal, we will systematically explore the molecular mechanisms by which AML- specific MYC mutations sustain leukemogenesis and increase the AraC sensitivity of AML cells, which may lead to new approaches for risk stratification, and novel approaches for therapy.

PI_NAMEs: FERRARO, FRANCESCA  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Affect;Alleles;B lymphoid malignancy;Binding Sites;Breeding;Candidate Disease Gene;candidate identification;career;career development;cell transformation;Cells;Characteristics;chemotherapy;ChIP-seq;Chromosome 8;cohort;Data Analyses;Data Set;design;Development;Development Plans;Diagnosis;differential expression;Disease remission;DNA Binding;Dose;Doxycycline;effectiveness evaluation;experimental study;Frequencies;Future;Gene Expression Profile;Genes;Genetic Transcription;Genomics;Goals;Growth;Half-Life;Hematopoietic;Hematopoietic stem cells;improved;improved outcome;In Vitro;in vivo;insight;Karyotype;Knock-in;Knowledge;leukemia;Leukemic Cell;leukemic transformation;leukemogenesis;Mediating;medical schools;Missense Mutation;Modeling;Molecular;mouse model;Mus;mutant;Mutation;MYC Box;MYC Family Protein;novel strategies;novel therapeutic intervention;NPM1 gene;Oncogenic;Outcome;Output;overexpression;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Physiological;predictive tools;Property;Proteins;Recurrence;research and development;Research Project Grants;Resistance;Resources;response;Risk;risk stratification;RNA Splicing;Role;Sampling;Series;single-cell RNA sequencing;skills;Solid Neoplasm;System;Technology;Translations;treatment response;Universities;Washington;Work

PROJECT_TITLE: The Role of MYC Mutations in acute Myeloid Leukemia

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Genetics;Immunization;Infectious Diseases;Lyme Disease;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative RFA-AI-19-037 The Mice Against Ticks project seeks to prevent new cases of Lyme disease by heritably immunizing the white-footed mice that are most responsible for infecting ticks. Engineering local mouse populations to carry naturally occurring immunity elements isolated from other mice in a reversible fashion may be the safest and most minimal intervention capable of preventing Lyme disease for many decades. Our open and community-guided approach has generated considerable interest and apparent enthusiasm from the residents of Nantucket and Martha’s Vineyard, suggesting that it may be widely adopted to protect communities suffering from Lyme disease throughout the Northeast and Upper Midwest.

PI_NAMEs: ESVELT, KEVIN  (contact);JAENISCH, RUDOLF ;MARASCO, WAYNE A.;MARKOULAKI, STYLIANI ;TELFORD, SAM R

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: acaricide;Adopted;Albumins;Alleles;Animals;Antibodies;Area;B-Lymphocytes;Back;Binding;Borrelia burgdorferi;Cell Line;Chromosomal translocation;Communities;cost;Deer;Disadvantaged;Disease;Disease Reservoirs;disease transmission;Elements;embryonic stem cell;Engineering;Enterobacteria phage P1 Cre recombinase;Environment;Epitopes;ES Cell Line;exposed human population;Feedback;field study;fitness;Gene Transfer Techniques;Genes;Geography;Germ Lines;Goals;Heritability;Immunity;Immunization;Immunize;In Vitro;in vitro activity;in vivo;Incidence;Individual;interest;Intervention;Investments;Light;Link;Liver;Lyme Disease;Methods;Midwestern United States;model organism;Mus;Mutation;OspA protein;pathogen;Play;Population;prevent;Prevention;Prevention strategy;Production;Protective Clothing;Reciprocal Translocation;Recombinants;Research Personnel;Resistance;resistance gene;Risk;Role;Sorting;System;Testing;Tick-Borne Diseases;Ticks;Time;Transgenes;Transgenic Organisms;transmission process;underdominance;Vaccinated;White-Footed Mouse;Work;Zoonoses

PROJECT_TITLE: Heritable immunization of the white-footed mouse reservoir of Lyme disease


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: Princeton

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative  Gender diverse children often experience disparities in mental health and well-being. Further questions concern the stability of their gender as that has implications for medical transitions. The proposed work would examine the role of gender beliefs and self-categorization in predicting mental health and well-being, as well as provide better estimates of rates of stability and change across time in the identities of both cisgender and gender diverse youth.

PI_NAMEs: OLSON, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;Belief;Categories;Child;cisgender;Clinical Psychology;Cognition;cognitive development;cognitive process;cohort;Communication;Congresses;Development;Disparity;Environmental Exposure;Event;experience;Exposure to;flexibility;Gender;gender diverse;gender diversity;gender fluid;Gender Identity;Grant;Health;health disparity;Human;Human Development;Individual;Individual Differences;Influentials;Laws;Learning;Life;life span;Link;Liquid substance;Longitudinal Studies;Measures;Medical;Mental Health;nonbinary;Parents;Participant;Perception;Personal Satisfaction;Persons;Procedures;Process;Recontacts;recruit;Research;Role;Sampling;Sampling Studies;Schools;social;social cognition;Social Development;Social Environment;Societies;Stereotyping;Testing;theories;Time;transgender;Update;Variant;Work;Youth

PROJECT_TITLE: Views of Gender in Adolescence

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

PHR: PROJECT NARRATIVE During heart failure, the integrity of T-tubules, specialized cell membrane structures essential for normal heart function, deteriorates making heart contraction less efficient. It is not known whether T-tubules can be repaired as a potential treatment for heart failure. This proposal examines how different activities of a potential membrane repair protein, MG53, contribute to heart disease and whether they can be leveraged toward improving T-tubule structure and overall heart function.

PI_NAMEs: SONG, LONG-SHENG  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acceleration;Acute;Animal Model;Aorta;biological adaptation to stress;Biology;C-terminal;Cardiac;Cardiac Myocytes;Cell Membrane Structures;Cells;Chronic;confocal imaging;Congestive Heart Failure;Coupling;Data;design;Deterioration;Development;Disease;Electrophysiology (science);Failure;Functional disorder;Goals;healing;Health;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Human;Imaging Techniques;Impairment;improved;In Situ;Injury;insight;interdisciplinary approach;IRS1 gene;Ischemia;Knock-in;Knock-in Mouse;knockin animal;Maps;Mass Spectrum Analysis;Measures;Mediating;Membrane;membrane excitation;Membrane Potentials;Microfilaments;Modeling;Molecular;Molecular Biology;mouse model;Muscle Cells;Muscle Contraction;mutant;Mutation;Myocardial Contraction;Myocardium;novel;Outcome;overexpression;Pathologic;Pathology;Patients;Physiological;PI3K/AKT;Pilot Projects;Play;pressure;Process;programs;Proteins;Proteolysis;Proteome;Regulation;repair enzyme;repair function;repaired;Research;response;restoration;Rodent;Role;Sarcoplasmic Reticulum;Seminal;Signal Transduction;Stress;Striated Muscles;Structure;Surface;System;targeted treatment;Testing;Therapeutic;trafficking;Treatment Failure;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Up-Regulation;Vesicle

PROJECT_TITLE: Molecular Determinants of MG53 in Heart Structure and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CCHF-S(01)]


ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: Project Narrative  This FASEB conference will address the emerging field of how gene expression is mediated by various molecular machines in the cell nucleus. Collectively termed nuclear bodies, these machines play key roles in the final production of transcripts destined either for translation into proteins or for regulatory roles within the nucleus. Research in this field has recently uncovered links between nuclear bodies and cancer, which will be a major focus of this meeting, including two Keynote Lectures and many other talks.

PI_NAMEs: PEDERSON, THORU  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: American;Attention;Biology;Biophysics;Budgets;career;career development;Cell Nucleus;Cellular biology;Communities;Disease;Enrollment;equity, diversity, and inclusion;falls;Foundations;Funding;Gene Expression;Genomics;graduate student;human disease;Interphase Chromosome;lectures;Link;Liquid substance;Malignant Neoplasms;Mediating;meetings;Mentors;Molecular Machines;Nuclear;Participant;Phase;Play;Postdoctoral Fellow;posttranscriptional;Production;professor;programs;Proteins;Publishing;Reporting;Research;RNA;Role;Science;Scientist;Societies;Subcellular structure;symposium;Transcript;Translations

PROJECT_TITLE: Nuclear Bodies: Hubs of Genomic Activity

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Precision Medicine

ORG_CITY: SILVERTHORNE

ORG_NAME: KEYSTONE SYMPOSIA

ORG_STATE: CO

PHR: PROJECT NARRATIVE Non-alcoholic fatty liver disease (NAFLD) is a growing health burden worldwide. This disease encompasses liver steatosis that may progress to steatohepatitis, and ultimately, to life threatening conditions such as cirrhosis and live cancer. However, despite more than 15 years of research, the main unmet medical need remains the identification of specific therapies against this disease; this Keystone Symposia conference will review the latest research in the field so that attendees can establish new collaborations to aid in the search of precision therapeutics based on NAFLD disease diversity.

PI_NAMEs: SHEPPARD, TERRY L. (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Affect;Canada;cancer risk;career;Cirrhosis;Clinical;clinical practice;Clinical Trials;Collaborations;Communities;Complex;Disease;Disease Progression;Educational workshop;effective therapy;Epigenetic Process;Ethnic Origin;Event;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Fibrosis;Gender;Generations;Genetic;Genetic Predisposition to Disease;Genetic study;Genetic Techniques;Health;Heterogeneity;Human Genetics;improved;Incidence;Inflammation;International;Knowledge;Learning;Life;Liver;Malignant Neoplasms;Measurement;Medical;member;Metabolic;Methodology;Molecular;Molecular Genetics;molecular phenotype;Morbidity - disease rate;mortality;multidisciplinary;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel strategies;Outcome;Participant;Persons;Phenotype;posters;Pre-Clinical Model;Precision therapeutics;Prevalence;programs;protective allele;protective factors;Research;Research Personnel;Risk;Science;Severity of illness;Steatohepatitis;symposium;Therapeutic;Treatment Efficacy;treatment response;Work

PROJECT_TITLE: NASH and Fibrosis: From Molecular Phenotypes to Precision Therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (J3)]


PHR: PROJECT NARRATIVE Cancer immunotherapy, a collection of approaches that coax patients’ immune systems to target cancer cells, has been a lifesaving advancement for certain patients and cancers. While many approaches in this area have shown remarkable effectiveness, the technologies do not apply to all cancers. This conference takes a “bedside- to-bench” approach that brings together clinicians and basic researchers from across academia and industry to take a critical look at clinical trial failures so as to glean insights that will guide novel research efforts to improve future cancer immunotherapy treatments and outcomes.

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Academia;Area;Back;Basic Science;Behavior;bench to bedside;Biomedical Engineering;British Columbia;Canada;cancer cell;cancer clinical trial;cancer immunotherapy;Cancer Vaccines;cell type;Cellular biology;cellular engineering;cellular imaging;Clinic;Clinical;clinical practice;Clinical Trials;Collaborations;Collection;combinatorial;Communities;design;Development;Educational workshop;effective therapy;Effectiveness;engineered T cells;Evolution;Failure;Future;Glean;high dimensionality;Image;imaging approach;Immune;immune checkpoint blockade;Immune response;Immune system;Immunologist;Immunology;Immunooncology;Immunotherapy;improved;Industry;insight;Knowledge;Learning;Life;Malignant Neoplasms;meetings;Methodology;new technology;next generation;novel;Outcome;patient subsets;Patients;posters;preclinical study;rational design;Refractory;Research;Research Personnel;Resistance;resistance mechanism;Scientist;spatiotemporal;success;symposium;T-Lymphocyte;Technology;Therapeutic;Time;Touch sensation;Translating;translational scientist;treatment and outcome;tumor;Tumor Antigens;Tumor Immunity;tumor immunology

PROJECT_TITLE: Cancer Immunotherapy: Beyond Immune Checkpoint Blockade and Overcoming Resistance


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

PHR: PROJECT NARRATIVE As we emerge from the COVID pandemic, there is an urgent need for the TB research community to re- engage in scientific interactions, to exchange ideas and to establish new collaborations. As the community rethinks ways to prevent and treat TB, everything begins with a thorough understanding of the fundamental biology of TB immunopathogenesis. This Keystone Symposia conference is designed to re-invigorate progress in the tuberculosis field by creating an engaging environment to foster new ideas and networking opportunities for trainees and investigators at every career stage.

PROGRAM_OFFICER_NAME: MULACH, BARBARA L

PROJECT_TERMS: Address;Affect;Biological;Biology;career;career development;Cells;Clinical;clinical practice;Collaborations;Colorado;Communities;COVID-19 pandemic;design;Disease;disease model;Educational workshop;Electronic Medical Records and Genomics Network;Environment;Fostering;fundamental research;Germination;Goals;Granuloma;Health;holistic approach;human old age (65+);improved;Individual;Infection;International;Investigation;Knowledge;Learning;Life Cycle Stages;Life Style;member;Methodology;multidisciplinary;Mycobacterium tuberculosis;new technology;non-tuberculosis mycobacteria;novel;Outcome;pandemic disease;Participant;pathogen;patient population;Persons;posters;Pre-Clinical Model;Predisposition;prevent;Process;programs;Proliferating;Research;Research Personnel;Scientist;sound;Speed;Structure;symposium;Symptoms;Techniques;tool;Translations;Tuberculosis;tuberculosis treatment;Work

PROJECT_TITLE: Tuberculosis: The Host-Pathogen Interface

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) is a significant cause of death worldwide, claiming the lives of 17.9 million people annually. By bringing together key opinion leaders in the cardiac and vascular epigenetics communities, as well as external experts in other related fields such as systems genetics, this conference creates a unique opportunity to cross traditional disciplinary boundaries in the cardiovascular field. This will be the first time that this group has come together for a meeting and creates an opportunity to forge new collaborations and to initiate crosstalk in the growing field of cardiovascular epigenetics and gene regulation.

PROGRAM_OFFICER_NAME: REIS, JARED P

PROJECT_TERMS: Adult;aging population;Area;Basic Science;Big Data;Biology;Blood Vessels;Cardiac;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cells;Chromatin;Chronic;clinical practice;Collaborations;Communities;Country;Data;data sharing;design;Development;Disease;Educational workshop;Ensure;Environment;Enzymes;Epigenetic Process;epigenetic regulation;epitranscriptomics;forging;Fostering;Functional disorder;Gene Expression;Gene Expression Regulation;Genes;Genetic;Germany;Health;improved;Inflammation;Knowledge;Learning;Life;Life Expectancy;Link;Literature;Malignant Neoplasms;meetings;member;Metabolism;Methodology;Modification;multidisciplinary;Myocardial;new technology;novel therapeutic intervention;novel therapeutics;Nucleic Acids;Outcome;Pathway interactions;Persons;posters;programs;Regulatory Pathway;Research;Research Personnel;Scientist;symposium;System;Therapeutic;Time;Translational Research;Work

PROJECT_TITLE: Cardiovascular Epigenetics and Gene Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (J2)]


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases

PHR: PROJECT NARRATIVE Antibodies carry an enormous potential in the treatment of human disease, across ages, genders, races, and geographic locations. For example, in cancer, effective antibody therapies are evolving rapidly, providing opportunities for specific targeting of the broad range of malignancies in different disease stages; in infectious diseases, particularly emerging infectious diseases, investigators can rapidly identify therapeutic antibodies for lifesaving treatment or prophylaxis. This Keystone Symposia conference aims to provide the platform for sharing and integration of knowledge for experts and trainees alike to learn about the newest developments in antibody engineering that will be applied to prevent, treat and cure important human diseases.

PROGRAM_OFFICER_NAME: BARTELS, ADELINA EWURA-ABENA

PROJECT_TERMS: Academia;Age;Antibodies;antibody engineering;Antibody Therapy;Area;Biological;Biological Response Modifier Therapy;career;career development;Clinical;clinical development;clinical efficacy;clinical practice;Collaborations;Colorado;Communicable Diseases;Communities;Data;Development;Discipline;Disease;drug development;Educational workshop;Electronic Medical Records and Genomics Network;Emerging Communicable Diseases;Engineering;Equilibrium;Evolution;Failure;forging;Future;Gender;Geographic Locations;Goals;Human;human disease;Immunologics;improved;Industry;innovation;insight;International;Knowledge;knowledge integration;Learning;Life;Malignant Neoplasms;member;Methodology;Mind;Modern Medicine;multidisciplinary;novel;novel therapeutics;Outcome;Pathologic;Pharmaceutical Preparations;pharmacologic;posters;prevent;Property;Prophylactic treatment;Race;Research;Research Personnel;Safety;Scaffolding Protein;Scientist;sharing platform;sound;Specialist;Specificity;success;symposium;Therapeutic;Therapeutic antibodies;Therapeutic Research;Translations;virtual;Work

PROJECT_TITLE: Antibodies as Drugs: The Art in Antibody Engineering


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Microbiome;Prevention;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE Immunology has rapidly become one of the most promising scientific areas associated with cancer research and treatment. This Keystone Symposia conference is intended to unite the fields of inflammation, microbiology and cancer and will enable researchers in innate immunity, adaptive immunotherapy, cancer vaccines, microbiome and immune metabolism to interact on an international scale. The conference will be instrumental in shaping basic and translational research in these overlapping fields, with an aim of advancing novel cancer treatments.

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Academic support;Adaptive Immune System;adaptive immunity;Adjuvant;Affect;angiogenesis;Animal Experiments;anti-cancer research;Area;Asia;Attention;Basic Science;Cancer Biology;cancer health disparity;cancer immunobiology;Cancer Patient;cancer prevention;cancer therapy;Cancer Vaccines;CAR T cell therapy;career;Cell Proliferation;Cells;Cessation of life;checkpoint inhibition;Chemotherapy and/or radiation;Clinical;Clinical Investigator;clinical practice;clinical translation;Collaborations;combat;Communities;comorbidity;Complex;diet and cancer;Disparity population;Educational workshop;Environment;Epithelium;ethnic difference;Ethnic Origin;Exposure to;Future;Goals;Government;health equity;host microbiome;Immune;Immune response;Immunity;Immunology;immunoregulation;Immunotherapy;improved;Industrialization;Inflammation;Inflammatory;insight;International;Knowledge;Link;Location;Major Histocompatibility Complex;Malignant Neoplasms;meetings;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;Methodology;Microbiology;microbiome;microbiome research;microbiota;Mutagenesis;Natural Immunity;neoplastic cell;novel;Organ;Outcome;patient response;Play;posters;Predisposition;prevent;Prevention strategy;Primary Neoplasm;Process;programs;Proliferating;Race;racial difference;Radiation therapy;receptor;Research;Research Personnel;response;Role;Scientist;Shapes;side effect;Signal Transduction;Site;Surface;symposium;Taiwan;Therapeutic;Toxic effect;Training;translational potential;Translational Research;treatment response;treatment strategy;tumor;Tumor Immunity;tumor immunology;tumor metabolism;tumor microenvironment;tumor progression;Tumor Promotion;Work

PROJECT_TITLE: Microbiota and Cancer Immunity


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE Neurodegenerative diseases are becoming more prevalent as our population ages, and the societal impact of these diseases is increasing in parallel due to the current lack of effective treatments. This Keystone Symposia conference, along with a joint conference on Neuroimmune Interactions, offers a unique opportunity to convene scientific experts in neuroscience, immunology and drug discovery to address these challenges. These conferences feature academic, industrial and governmental researchers and will facilitate the sharing of results as well as drive discussions that will define scientific frontiers in neurodegenerative disease research in the coming years.

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TITLE: Neurodegenerative Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (43)]


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE Neuroimmunology is a rapidly growing field at the intersection of neurobiology and immunology that has important implications for the treatment of disorders of the central nervous system (CNS), the gut and other tissues. This Keystone Symposia conference, along with a joint conference on Neurodegenerative Diseases, brings together experts on neuroscience, immunology, genomics, microbe-host interactions and drug development. Providing a forum for interactions among these groups of researchers will promote scientific cross-fertilization to accelerate research in the neuroimmunology field and support the development of new therapeutics.

PROJECT_TERMS: Acceleration;Area;Basic Science;Behavior;biological research;Biomedical Research;Brain;Brain Diseases;career development;Cells;Central Nervous System;Central Nervous System Diseases;clinical practice;Collaborations;Communities;design;Development;Discipline;Disease;drug development;Educational workshop;Electronic Medical Records and Genomics Network;Fertilization;Functional disorder;Future;Genomics;Health;Heterogeneity;host-microbe interactions;Human;Immune;Immune system;immune system function;Immunologist;Immunology;immunoregulation;Immunotherapeutic agent;improved;Industry;innovation;Interdisciplinary Study;Joints;Knowledge;Learning;life span;Location;meetings;member;Methodology;Microglia;multidisciplinary;Nervous System;Nervous System Disorder;Neurobiology;Neurodegenerative Disorders;Neuroimmune;neuroimmunology;Neurosciences;New Mexico;novel therapeutics;Outcome;pathogen;Pathway interactions;Peripheral Nervous System;posters;programs;Research;Research Personnel;Scientist;Signal Transduction;symposium;Technology;Therapeutic;Tissues;Translational Research;Work

PROJECT_TITLE: Neuroimmune Interactions: Nervous System and Immune Cell Heterogeneity in Health and Disease


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases

PHR: PROJECT NARRATIVE The innate immune system is our first line of defense against infection and given the expanding scope of pathogens in our global ecosystem, it has become essential to understand the complex mechanisms of innate immunity. This Keystone Symposia conference will feature the latest insights on pathogen sensing, immune signaling and their connections to health and disease and will highlight the latest technologies for exploring these systems in greater detail. By bringing together researchers from academia and industry, the conference will also provide a unique opportunity to optimize targeting innate immunity pathways to improve human health.

PROJECT_TITLE: Innate Immunity Across the Molecular, Cellular, Tissue and Therapeutic


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Gonorrhea remains a worldwide public health problem given the incidence of disease (87 million cases/year) and the emergence of Neisseria gonorrhoeae strains resistant to currently used antibiotics. The MtrCDE efflux pump plays a critical role in development of antibiotic resistance expressed by N. gonorrhoeae, and the work proposed herein will address how the genes encoding the efflux pump are regulated at the level of transcription and define the structure-function relationships of the MtrD transporter protein. The results will advance basic science knowledge that can be used to develop novel strategies that target this efflux pump for future therapeutic strategies.

PI_NAMEs: SHAFER, WILLIAM MAURICE (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Adaptor Signaling Protein;Address;Amino Acids;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Cationic Peptides;Antimicrobial Resistance;Azithromycin;Bacteria;Basic Science;beta-Lactams;bile salts;Binding;Biological Assay;Carrier Proteins;cathelicidin;cathelicidin antimicrobial peptide;Cefixime;Ceftriaxone;Cephalosporins;Clinic;Clinical;Collaborations;combat;Communities;Country;Cryoelectron Microscopy;Data;Development;Disease;Distal;DNA;Doctor of Philosophy;Drug Efflux;efflux pump;Elements;experimental study;Exposure to;Female;fitness;Focal Infection;Future;gene discovery;Gene Expression;gene repression;Generations;Genes;Genetic;genetic resistance;Genetic Transcription;Genitalia;Goals;Gonorrhea;Gynecologic;Health;Horizontal Gene Transfer;Host Defense;Human;human pathogen;In Vitro;in vivo;Incidence;Infection;Infectious Agent;Introns;Knowledge;Link;Macrolides;male;Mediator;Medical;Membrane;mosaic;mouse model;Mucous Membrane;Mus;Mutation;Neisseria;Neisseria gonorrhoeae;neutrophil;novel;novel strategies;Nucleotides;pathogen;Peptides;periplasm;Pharmaceutical Preparations;Play;Predisposition;Productivity;Progesterone;Proliferating;promoter;Promoter Regions;Proteins;Proton-Motive Force;Public Health;Pump;Refractory;reproductive;reproductive tract;Research Personnel;Resistance;resistant strain;Resources;response;Role;Sepsis;Sexually Transmitted Diseases;Structure;Structure-Activity Relationship;Surface;System;Tetracyclines;Therapeutic;therapeutic target;tool;Transcriptional Regulation;United States;Virulence Factors;Work

PROJECT_TITLE: Gonococci:  Genetics of Resistance to PMN Proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(02)M]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project narrative  A large class of inherited disorders is attributable to mutations that cause atypical termination of translation of the genetic code. These mutations activate a cellular quality control mechanism called nonsense-mediated mRNA decay (NMD) that is the focus of this proposal. We expect that our work will provide new insights into the mechanism of NMD and, as a consequence, will likely have the public health benefit of improving novel therapeutic approaches to the genetic disorders that trigger NMD.

PI_NAMEs: JACOBSON, ALLAN S (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Acceleration;Address;Alternative Splicing;ATP Hydrolysis;Binding;Complex;Cryoelectron Microscopy;Cytoplasm;decapping enzyme;Dissociation;Eukaryota;Event;experimental study;Gene Rearrangement;Genes;Genetic Code;Genetic Diseases;Goals;Health Benefit;helicase;Hereditary Disease;human disease;improved;insight;Link;Mediating;Messenger RNA;Modeling;Molecular;Molecular Biology;Monitor;mRNA decapping;mRNA Decay;mRNA Transcript Degradation;Mutation;Nonsense Mutation;novel therapeutic intervention;Open Reading Frames;Organism;Pathway interactions;premature;Process;Proteins;Pseudogenes;Public Health;Quality Control;recruit;Ribosomes;Role;Terminator Codon;Therapeutic;tool;Transcript;Transcription Initiation;Translation Initiation;translational genetics;Translations;Work;yeast genetics;Yeast Model System;Yeasts

PROJECT_TITLE: Translation, targeting, and decay of yeast nonsense-containing mRNAs

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_NAME: NATIONAL DISEASE RESEARCH INTERCHANGE

PHR: Program Director/Principal Investigator (Bell, Thomas, J): Project Narrative The research demand for human tissues continues to grow and the HTORR program provides a unique service to biomedical investigators nationwide whose research requires human tissues, organs and well annotated data. Over the past 4 years, nearly 500 scientific papers were published by scientists who used HTORR-provided tissues, confirming HTORR's indispensable contribution to the biomedical research community and the impact of these services on the search for new treatments and cures for common and rare diseases, including HIV/AIDS. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: BELL, THOMAS J (contact)

PROGRAM_OFFICER_NAME: MURPHY, STEPHANIE

PROJECT_TERMS: Administrative Supplement;Award;Awareness;Biomedical Research;Body System;Communication;Communities;Custom;Data;Databases;Development;Disease;Donor Selection;Elements;empowerment;Ensure;Funding;Grant;HIV/AIDS;Human;human disease;Human Resources;human tissue;Improve Access;improved;Industry;Infrastructure;innovation;Methodology;Methods;Mission;Modeling;Modification;Normal Range;Organ;outreach;Paper;Principal Investigator;Process;programs;prospective;Protocols documentation;Publishing;Rare Diseases;Recovery;Research;Research Personnel;Resources;Sampling;Scientist;Services;Shipping;Site;Source;Time;tissue resource;Tissues;Training;United States National Institutes of Health

PROJECT_TITLE: Research Resource for Human Organs and Tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;HIV/AIDS

PROJECT_TITLE: Core Management

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D]


ORG_CITY: BURLINGTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE The inside of our cells is a complex jumble of signals that must be interpreted in space in time to regulate dynamic cell processes. To support this the signal source must be in close proximity to the desired target. The current application proposes to investigate how the distribution of mitochondria (signal source) within our cells supports protein modifications (target) required to coordinate cell attachment and movement.

PI_NAMEs: CUNNIFF, BRIAN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Actins;Active Biological Transport;Adaptor Signaling Protein;Adhesions;Architecture;Automobile Driving;BCAR1 gene;Bioenergetics;Bypass;cell motility;Cell Physiology;Cell-Matrix Junction;Cells;cofilin;Complex;Consumption;Cysteine;Cytoplasm;Cytoskeleton;Data;density;Embryo;Event;Exhibits;experimental study;extracellular;Fibroblasts;Focal Adhesions;Frustration;Gene Expression;Gene Expression Profile;Genes;Hydrogen Peroxide;insight;Label;Laboratories;link protein;live cell imaging;Maps;Mediating;Membrane;Microtubules;migration;mimetics;Mitochondria;Mitochondrial Membrane Protein;Molecular;Motor;Movement;Mus;mutant;N-Cadherin;Nuclear;Outer Mitochondrial Membrane;oxidation;Oxidation-Reduction;Peripheral;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Population;Positioning Attribute;Post-Translational Protein Processing;Process;protein function;protein structure;Proteins;PTPN12 gene;Publishing;Reactive Oxygen Species;Reporting;Role;Signal Transduction;Signaling Molecule;Site;Source;Structure;Supporting Cell;Testing;Time;trafficking;transcriptome sequencing;Vinculin

PROJECT_TITLE: Mitochondrial positioning regulates redox-signaling during cell migration

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse;Women's Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The ultimate goal of these experiments is to expand our understanding of the molecular basis of opioid use disorder (OUD). Using single nuclei RNA sequencing methods, we identified genes in the brain associated specifically with the development of compulsive opioid taking in male rats. This proposal expands these studies to characterize cell type-specific alterations in gene expression associated with voluntary opioid taking in female rats as well as acute and prolonged withdrawal timepoints in both sexes in order to identify opioid- and withdrawal-induced molecular changes that could be targeted by new medications to treat OUD.

PI_NAMEs: CRIST, RICHARD C.;SCHMIDT, HEATH D (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Abstinence;Acute;addiction;Address;Adult;Anatomy;antagonist;arm;base;Behavior;Brain;Brain region;Buprenorphine;Cell Nucleus;cell type;Cells;Clinical Research;Corpus striatum structure;Country;Data;Data Set;Development;differential expression;Disease;Dose;Drug Metabolic Detoxication;Drug Targeting;Effectiveness;experimental study;FDA approved;Female;Fluorescent in Situ Hybridization;Functional disorder;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Goals;Health Services Accessibility;Healthcare Systems;Home;Human;Individual;Injections;innovation;insight;interest;Intraperitoneal Injections;Knowledge;Literature;long term abstinence;male;medication for opioid use disorder;Methadone;Methods;Molecular;Morphine;morphine administration;mu opioid receptors;Mus;Naltrexone;neural;neurobiological mechanism;neurochemistry;Neuroglia;neuromechanism;Neurons;new therapeutic target;novel;novel therapeutics;Nucleus Accumbens;Opioid;Opioid Analgesics;opioid exposure;opioid use disorder;opioid withdrawal;overdose death;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Pilot Projects;Play;Population;pre-clinical;preclinical study;prescription opioid;prevent;prolonged abstinence;Public Health;Rattus;Relapse;Research;Rodent;Role;Saline;Self Administration;sex;Sex Differences;single nucleus RNA-sequencing;Sprague-Dawley Rats;Techniques;therapy development;Time;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptomics;United States;Withdrawal;Women's cohort

PROJECT_TITLE: Single-nucleus transcriptomics in rat striatum following morphine administration and withdrawal

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Lung;Microbiome

PHR: The Oropharyngeal Microbiome in COVID-19 Project Narrative (Summary) SARS-CoV-2 first infects the upper respiratory tract (URT), where it stays localized until cleared or it extends to the lower respiratory tract (LRT) to cause pneumonia, but why infection sometimes stays localized in the URT but sometimes extends to involve the LRT is unknown. Human body surfaces are colonized with microorganisms including bacteria (the Microbiome) that vary with age, disease or other factors and can affect genes and immune function, and we discovered in COVID-19 patients that the URT microbiome was abnormal and correlated with disease severity, suggesting that the URT microbiome may influence progression of COVID-19. In this project we will investigate the URT microbiome in people predisposed to severe COVID-19 (based on age, diabetes, obesity), and use a novel mouse model to determine how it alters URT and LRT genes that are important in SARS-CoV-2 infection.

PI_NAMEs: COLLMAN, RONALD G (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: 2019-nCoV;ACE2;Address;advanced disease;Affect;Age;airway epithelium;Animal Model;antimicrobial;aspirate;Bacteria;Blood;Body mass index;Body Surface;Cells;Clinical;cohort;Communities;comorbidity;COVID-19;COVID-19 pathogenesis;COVID-19 patient;COVID-19 risk;COVID-19 severity;Data;Diabetes Mellitus;diabetic;Disease;Disease susceptibility;dysbiosis;Economics;Elderly;endotracheal;Environment;Epithelial Cells;Exhibits;Future;Gender;gene function;Genes;Genetic;Goals;Hand;Heterogeneity;Hospitalization;Human;Human body;human old age (65+);Immune;immune function;Immune response;Immunity;immunoregulation;Individual;Infection;Inflammation;Influenza;Innate Immune Response;innovation;insight;Interferons;Knowledge;Link;Lower respiratory tract structure;Lung;lung microbiome;lung microbiota;Lymphocyte;microbial;microbiome;microbiota;microorganism;Modeling;Modification;Mononuclear;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mus;Nasopharynx;Natural Immunity;neutrophil;novel;Obesity;Oropharyngeal;Outcome;Patients;Persons;Phase;Play;Pneumonia;prototype;receptor;receptor expression;Resolution;respiratory;Respiratory Failure;respiratory infection virus;respiratory microbiome;respiratory virus;response;Risk;Sampling;SARS-CoV-2 infection;severe COVID-19;Severities;Severity of illness;Shapes;social;Source;Specimen;Therapeutic Intervention;Upper respiratory tract;Viral;Virus Receptors;Work

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MILWAUKEE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE General anesthetic-induced developmental neurotoxicity, which is linked to several significant long-term consequences including behavioral deficits, has largely unknown cellular and molecular mechanisms. Our preliminary data suggests a strong direction for further investigation by showing that anesthesia is toxic to mitochondria, which is extremely important for neuron function. Thus, to address the aforementioned need, the goal of our study is to uncover the unexplored functions of mitochondrial signaling in anesthetic-induced neurotoxicity and investigate the efficacy of small molecule-mediated neuroprotection which targets mitochondrial pathways.

PI_NAMEs: BAI, XIAOWEN  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Acute Brain Injuries;Address;Age;Anesthesia procedures;Anesthetics;Animals;Area;Behavior;Behavioral;brain cell;Cell Death;cell type;Cessation of life;Child;Cognitive deficits;CRISPR/Cas technology;Data;developmental neurotoxicity;Epidemiology;gain of function;General anesthetic drugs;Genes;Goals;high throughput analysis;Human;human induced pluripotent stem cells;Impaired cognition;Impairment;Injury;innovation;Investigation;Knowledge;Link;loss of function;Mediating;Mitochondria;mitochondrial dysfunction;Molecular;mouse model;multi-photon;multiple omics;Mus;Neurons;neuroprotection;Neurosciences;neurotoxic;neurotoxicity;neurotransmission;novel;Operative Surgical Procedures;Pathway interactions;Post-Transcriptional Regulation;prevent;Problem behavior;programs;Public Health;real-time images;Research;Signal Transduction;single-cell RNA sequencing;small molecule;stem cell model;therapeutically effective;tool;Transgenic Mice;United States Food and Drug Administration;Untranslated RNA

PROJECT_TITLE: Mitochondria and anesthetic-induced developmental neurotoxicity

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Respiratory syncytial virus (RSV) is a significant cause of respiratory disease in infants, the elderly and immunocompromised. The goal of this project is to determine if a viral protein, called M2-1, affects expression of cellular and viral proteins by acting on their mRNAs. The information obtained could be of value for understanding how RSV causes disease, and in the longer term could aid development of antiviral agents and vaccines to control RSV infection.

PI_NAMEs: FEARNS, RACHEL  (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: 3' Untranslated Regions;Affect;Anti-viral Agents;antiviral drug development;Binding;Binding Sites;Biochemical;Biology;Bronchitis;Caring;cell growth regulation;Cells;Characteristics;Child;Code;combat;Complex;Coupled;crosslink;CXCL5 gene;Cysteine;Cytoplasm;Cytoplasmic Granules;Cytoplasmic Inclusion;Cytosol;Data;Development;Disease;Distal;effective intervention;Elderly;Elongation Factor;Epidemic;experience;experimental study;Family member;Filovirus;Fingers;Future;Gene Expression;Genes;Genetic Transcription;Genome;Goals;high resolution imaging;Histidine;Immune response;Immunocompromised Host;Immunoprecipitation;Inclusion Bodies;Infant;Infection;Infection prevention;innovation;insight;Length;Luciferases;member;Messenger RNA;Metabolism;Microscopy;Mononegavirales;mRNA Stability;mRNA Translation;novel;Pathogenesis;Play;Pneumonia;Pneumovirus;Poly(A)-Binding Proteins;polyadenylated messenger RNA;Polymerase;Positioning Attribute;Post-Transcriptional Regulation;posttranscriptional;promoter;Property;protein expression;Proteins;Public Health;Publishing;recruit;Reporter;Resolution;Respiratory Disease;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory syncytial virus RSV proteins;RNA;RNA Sequences;RNA Viruses;RNA-Directed RNA Polymerase;Role;Seasons;Suggestion;System;Testing;Transcript;Transcription Elongation;Transcriptional Elongation Factors;transcriptome sequencing;Translations;Vaccines;Viral;Viral Genome;Viral Pathogenesis;Viral Proteins;virology;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Determining the impact of respiratory syncytial virus M2-1 protein on post-transcriptional regulation of cellular and viral mRNAs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-S(02)]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: We have generated the first induced pluripotent stem cells (iPSCs) from a bat and discovered that these cells have unique properties relative to other mammalian iPSCs. Our research will provide novel insights into the molecular basis of bats’ unique native immunity.

PI_NAMEs: ZWAKA, THOMAS P. (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Address;Affect;Animal Model;Anti-Inflammatory Agents;Biological Models;Biology;Breeding;Cell Differentiation process;cell immortalization;Cell Line;Cell model;cell type;Cells;cellular pathology;Chiroptera;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;COVID-19;CRISPR/Cas technology;Data;Ebola;Echolocation;Engineering;Enzymes;Evolution;fascinate;fly;forward genetics;Genes;Genetic study;genetic testing;Goals;healthspan;Immune;Immune response;Immune system;Immune Tolerance;Immunity;In Vitro;induced pluripotent stem cell;Inflammasome;Inflammatory;Inflammatory Response;insight;ketogenesis;ketogentic;Knock-out;life span;Longevity;Mammals;marenostrin;Metabolic;Metabolism;metabolomics;model organism;Modeling;Molecular;Myeloid Cells;Natural Immunity;novel;Organoids;Outcome;Pathway interactions;Physiology;Play;Pluripotent Stem Cells;programs;Property;Protocols documentation;Radiation;Readiness;Research;Research Proposals;response;Role;Sampling;Series;Severe Acute Respiratory Syndrome;stem cells;System;Testing;Tissues;tool;transcriptomics;tumorigenesis;Viral load measurement;viral outbreak;Virus;Virus Diseases;Work

PROJECT_TITLE: Bat pluripotent stem cells as a novel experimental system


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Organ Transplantation;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: INDIANAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative/Relevance Heart transplantation is an ultimate treatment for end-stage heart failure, but its use is limited by a severe donor heart shortage. This proposed study is aimed at evaluating mesenchymal stem cell (MSC)-derived therapy applied with an ex vivo heart perfusion device to facilitate recovery of hearts from donation after circulatory death (DCD, thus increasing the number of available donor hearts), promote graft function, and improve outcomes of heart transplantation. The results from this project can provide foundation for potential clinical trials in that MSC secretions can be utilized to improve DCD hearts resuscitation, and help us gain mechanistic insights on therapeutic targets to limit ischemic injury in DCD hearts for transplantation.

PI_NAMEs: WANG, MEIJING  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Acute;Adoption;Animal Model;Attention;bone marrow mesenchymal stem cell;Cardiac;Cardiac Myocytes;cardiac repair;Cardiopulmonary Resuscitation;Cell secretion;Cessation of life;Circadian Rhythms;Clinical;Clinical Trials;Conditioned Culture Media;Cryopreservation;Data;Data Analyses;Deterioration;Devices;Donor person;Engineering;extracellular vesicles;Family suidae;Foundations;Gene Modified;Generations;Genes;Goals;graft function;Health;Heart;Heart failure;heart function;heart preservation;Heart Transplantation;Homeostasis;Human;Impairment;improved;improved outcome;in vivo;Infusion procedures;Injury;insight;Ischemia;ischemic injury;knock-down;Knockout Mice;Life;Mediating;Mesenchymal Stem Cells;Metabolic;Mitochondria;Modality;Mus;Muscle Cells;Myocardial;myocardial damage;myocardial injury;Myocardial Ischemia;Myocardium;novel strategies;Organ;Organ Viability;Outcome;paracrine;Patients;Performance;Perfusion;post-transplant;pre-clinical;preservation;prevent;Process;protective factors;Proteins;Publishing;Recovery;Recovery of Function;Recovery Support;Regulation;repaired;Reperfusion Injury;Reperfusion Therapy;Reporting;Resources;Resuscitation;Role;Source;stem cells;Stress;Structure;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Therapeutic Uses;Time;transcriptome;transcriptome sequencing;Translating;translational potential;transplant model;Transplantation;Treatment Efficacy;Warm Ischemia;Work

PROJECT_TITLE: Transplantation of hearts from donation after circulatory death

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Behavioral and Social Science;Data Science

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The mission of the Stanford BSSR training grant is to develop a cadre of highly trained behavioral and social scientists with advanced quantitative skills for dealing with complex data, with a focus on applications to heart, lung, blood, and sleep (HLBS) disorders. The BSSR program addresses a critical need to train investigators with primary skills in behavioral and social sciences to have advanced quantitative skills to deal with the increasingly complex large-scale multidimensional data from digital devices, wearables, electronic health records, social media, administrative health claims databases, and other sources.

PI_NAMEs: KING, ABBY C;NELSON, LORENE M (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Behavioral;Data Science;population health;pre-doctoral;Research;social;Training Programs

PROJECT_TITLE: Stanford BSSR Pre-Doctoral Training Program at the Intersection of Data Sciences with Behavioral, Social, and Population Health Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(50)]


NIH_SPENDING_CATS: Aging;Bioengineering;Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Women who have had an adverse pregnancy outcome (APO) have a lifetime of higher heart disease risk, but their heart disease risk factor levels might go back to normal levels after delivery. Measures of pulsatile vascular function, such as wave reflection and arterial stiffness, might be more sensitive for detecting excess heart disease risk after pregnancy. We propose these measurements in the large, diverse, and longitudinal nuMoM2b-HHS2 cohort to describe differences in vascular function in women with versus without different past APOs and to evaluate associations of vascular function with early pregnancy biomarkers and patterns in lifestyle behaviors to identify high risk women and strategies to reduce heart disease risk after APOs.

PI_NAMEs: LANE, ABBI DANIELLE (contact)

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: adequate sleep;adverse pregnancy outcome;Ancillary Study;Angiogenesis Inhibitors;arterial stiffness;Back;Behavior;behavioral phenotyping;Biological Markers;biomarker panel;biomarker signature;Birth;Blood Vessels;Cardiac health;Cardiovascular Diseases;cardiovascular disorder risk;cohort;Cohort Studies;Communities;comparison control;Data;Data Collection;Data Set;design;Development;Disease;Dose;Early identification;early pregnancy;Enrollment;Fetal Growth Retardation;First Births;follow-up;Functional disorder;Funding;genome sequencing;good diet;Greenland;Health;health goals;heart disease risk;hemodynamics;high risk population;High Risk Woman;Hypertension;hypertensive;improved;Individual;Inflammatory;innovation;Interleukin-6;Intervention;Knowledge;Left;Life Style;Life Style Modification;lifestyle data;Link;Measurement;Measures;middle age;modifiable lifestyle factors;molecular phenotype;Mothers;National Heart, Lung, and Blood Institute;Nulliparity;Participant;participant enrollment;Pathogenesis;Pathway interactions;Patient Self-Report;Pattern;Persons;Phenotype;Physical activity;Physiological;post pregnancy;Pre-Eclampsia;Pregnancy;pregnancy disorder;Premature Birth;Premenopause;pressure;Prevention strategy;Procedures;Race;Recording of previous events;Reporting;Research Personnel;Risk;Risk Factors;Sampling;sex;Structural defect;Systolic Pressure;Techniques;time interval;Vascular Diseases;Vascular Endothelial Growth Factor Receptor-1;Ventricular;whole genome;Woman;young adult

PROJECT_TITLE: Arterial Stiffness and Wave Reflection: Physiological Contributors to CVD after Adverse Pregnancy Outcomes

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The goal of the proposed United States-Zambia Trauma and Injury Research Training Program (US- Zambia TIRP) is to strengthen research capacity on the health, social and economic impact of trauma and injuries across the lifespan in Zambia through an innovative model of sustainable capacity development. The program aims to develop a core group of researchers focused on trauma and injuries (T&Is) in Zambia; promote research on key national priorities for T&Is in Zambia; and further strengthen sustainability and the research environment in Zambia by establishing a center to support T&I research in the future.

PI_NAMEs: HYDER, ADNAN A;MUNTHALI, JAMES ;PAICHADZE, NINO  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Acute;Address;Africa South of the Sahara;Alcohols;Chronic;Collaborations;Communities;Complement;Country;Data;Development;Documentation;economic impact;Economics;Emergency Situation;Evaluation;experience;Faculty;Goals;Government;Health;Home;Human Resources;Individual;Injury;innovation;Institution;Intervention;life span;mass casualty;Measurement;model development;Modeling;Natural Disasters;neglect;Policies;Production;programs;Public Health;Public Health Schools;Recording of previous events;Research;research and development;Research Personnel;Research Support;Research Training;response;Risk Factors;social;Social Impacts;Speed;symposium;Training;Training Programs;Trauma;United States;Universities;Urbanization;Washington;Work;Zambia

PROJECT_TITLE: Trauma and Injury Research Training Program-Zambia


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: COLLEGE STATION

ORG_DEPT: CHEMISTRY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Project Narrative Primary amines are ubiquitous in natural products and synthetic molecules. This proposal aims to transform this universal moiety into a variety of linkages for the synthesis of bioactive small molecules and polymer architectures. These methods will help the discovery of drug candidates and potential drug delivery systems, and shed light on underexplored reaction mechanisms

PI_NAMEs: MICHAUDEL, QUENTIN NICOLAS (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Agonist;Amines;Aminoglycosides;Architecture;Binding;bioactive scaffold;Carbohydrates;Catalysis;Chemicals;Chemistry;Collaborations;Complex;cost;design;Development;Disease;drug candidate;Drug Carriers;Drug Delivery Systems;drug discovery;Drug Kinetics;Event;Genetic Recombination;Hydrogen Bonding;improved;innovation;interest;invention;macromolecule;Methods;Modification;Molecular;multidisciplinary;Natural Products;novel therapeutics;Patients;Peptides;Pharmacologic Substance;physical property;Play;Polymers;Process;progenitor;programs;Proteins;Reaction;receptor;Research;Role;Route;Safety;small molecule;small molecule inhibitor;Stimulus;Temperature;tool;Toxic effect;Transition Elements

PROJECT_TITLE: Primary Amines as Versatile Precursors for the Synthesis of Bioactive Molecules and Macromolecular Drug Carriers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Mental Health;Prevention;Primary Health Care;Sleep Research

PHR: 8. PROJECT NARRATIVE Cardiovascular disease (CVD) is common, deadly, and costly, and adults with insomnia represent a large group of people at elevated risk of developing CVD in the future. This mechanistic study will determine if our updated insomnia treatment called SHADES improves biological factors thought to explain how insomnia promotes CVD and if these improvements are due to positive changes in sleep factors. This study could generate the critical evidence needed to justify a large clinical trial to determine if SHADES can help prevent CVD events, such as heart attacks and strokes.

PI_NAMEs: STEWART, JESSE C (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: active control;Address;Adult;Affect;Aftercare;Age;aged;Attention;Autonomic Dysfunction;Behavior Therapy;Biological;Biological Factors;Biological Markers;C-reactive protein;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Caring;Clinical;Clinical Trials;cognitive testing;Cognitive Therapy;cohort;collaborative care;Conditioned Insomnia;cost;Data;design;Development;Disparity population;Education;effective intervention;Effectiveness;Enrollment;Ethnic Population;Event;Exhibits;Federally Qualified Health Center;follow-up;Frequencies;Functional disorder;Future;Gene Expression;Gene Expression Profiling;genome-wide;Glycosylated hemoglobin A;Goals;Health;Healthcare Systems;Heart;heart rate variability;high risk;Homeostasis;Hygiene;improved;improvement on sleep;Inflammation;Inflammatory;inflammatory marker;Insulin Resistance;Interleukin-6;Internet;Intervention;intervention effect;intervention refinement;Mediating;Mediator;men;Metabolic;Minority;Modeling;Modernization;modifiable risk;Monitor;Morbidity - disease rate;Myocardial Infarction;National Heart, Lung, and Blood Institute;next generation;Outcome;Participant;Pathway interactions;patient population;Patients;Peripheral Blood Mononuclear Cell;Persons;Phase;phase III trial;prevent;Prevention strategy;Primary Care;primary care patient;primary outcome;programs;psychologic;public health relevance;racial population;Randomized;Research;Risk;Risk Factors;RNA;safety net;Science;screening;secondary outcome;sex;Site;Sleep;Sleep disturbances;sleep onset;Sleeplessness;Source;statistics;Stroke;Symptoms;systemic inflammatory response;Telephone;Testing;Update;Woman

PROJECT_TITLE: Strengthening Hearts by Addressing DisruptEd Sleep (SHADES) Mechanistic Trial

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Project Narrative Over 380,000 infants are born preterm in the United States each year, adding millions of dollars to health care costs and life-long consequences for survivors and families. Research progress on efforts to prevent and treat preterm birth are significantly hampered by the inability to accurately predict who is at risk for preterm birth before birth is already underway. In this project we will test a novel, operator-independent imaging tool—Quantitative Cervical Elastography System (Q-CES)—to, for the first time, quantify the underlying cervical tissue changes detectable in early pregnancy that precede preterm birth allowing critically needed improvement to correctly identify patients at risk for preterm birth to move both the clinical and scientific preterm birth field forward.

PI_NAMEs: STOUT, MOLLY  (contact);ZHAO, PEINAN

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: 37 weeks gestation;Address;American;Area Under Curve;Birth;black patient;Black race;Cervical;cervical remodeling;Cervical stiffness;Cervix Uteri;Characteristics;Clinical;clinical predictors;clinical translation;clinically actionable;cohort;college;Data;data standards;Diagnostic tests;Discipline of obstetrics;disorder risk;early pregnancy;elastography;Enrollment;Equipment;ethnic disparity;ethnic diversity;Family;Fetus;Gestational Age;Gynecology;Health;Health Care Costs;health disparity;Hispanic;Image;Imaging Device;imaging modality;improved;individualized prevention;Infant;intervention effect;Investments;Length;Longitudinal cohort;Measurement;Measures;Methodology;Methods;Modeling;mortality risk;multidisciplinary;neonatal morbidity;Neonatal Mortality;Not Hispanic or Latino;novel;Nulliparity;Outcome;parous;participant enrollment;Patients;Pattern;Perinatology;Populations at Risk;predictive modeling;Predictive Value;Pregnancy;pregnant;Premature Birth;pressure;prevent;Prevention;Prevention Measures;Prevention strategy;Process;prospective;Prospective cohort;racial disparity;racial diversity;Receiver Operating Characteristics;Recording of previous events;recruit;Research;Risk;Risk Factors;risk prediction model;risk stratification;Science;serial imaging;Standardization;Survivors;System;Techniques;Term Birth;Testing;Time;Tissues;Transvaginal Ultrasound;Treatment Cost;ultrasound;Uncertainty;United States;Woman

PROJECT_TITLE: Fully Quantitative Cervical Elastography for Prediction of Preterm Birth in Nulliparous Patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-L(02)M]


ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARATIVE The proposed research is relevant to public health because understanding the dynamics and mechanisms of neurochemical signaling and regulation in the lymph node is expected to inform the development of new types of treatments for chronic inflammation, autoimmunity, and even cancer. Tools to monitor rapid neurochemical signaling within intact immune tissue are lacking and we will fill this critical gap by developing tools to study neurochemical signaling in the lymph node with exquisite resolution. Thus, this proposal is relevant to part of the NIH’s mission that pertains to fostering fundamental creative discoveries and innovative research strategies as a basis for protecting and improving health.

PI_NAMEs: ROSS, ASHLEY E (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: analytical tool;Anions;Autoimmunity;biological systems;Brain;Buffers;Carbon;carbon fiber;Catecholamines;Cell Communication;Cells;Chemistry;Chronic;Communication;Creativeness;Data;Dendritic Cells;Detection;Development;Disease;Electrodes;Fostering;gastrointestinal;Goals;gut-brain axis;Health;Immune;Immune response;Immune system;Immunity;Immunomodulators;immunoregulation;Immunotherapy;improved;Inflammation;innovation;Knowledge;Lymph Node Tissue;lymph nodes;Malignant Neoplasms;Measurement;Measures;Melatonin;Mental Depression;mesenteric lymph node;Methods;Microelectrodes;Microfluidics;Mission;Monitor;multiplex detection;nerve supply;neurochemistry;Neurohormones;Neuroimmune;Neuroimmunomodulation;Neurons;Neurophysiology - biologic function;Neurotransmitters;Nitrogen;Norepinephrine;Organ;Outcome;Periodicity;Peripheral;Porosity;programs;Public Health;rapid detection;real time monitoring;receptor;Regulation;Research;Resistance;Resolution;Scanning;sensor;Signal Transduction;Slice;spatiotemporal;Surface;targeted treatment;Technology;temporal measurement;Testing;Time;Tissues;TNF gene;tool;United States National Institutes of Health;Work

PROJECT_TITLE: Monitoring neurochemical signaling dynamics in the lymph node

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative  This project seeks to identify causal neural mechanisms underlying unwanted, repetitive behaviors (compulsions). Using non-invasive brain stimulation, with or without coupled practice in a computer-based `habit override' task, we will modulate activity in a target brain region and measure effects on compulsive behaviors and related measures. This work could ultimately lead to the ability to treat compulsions more effectively by synergistically targeting the regions of the brain and the specific cognitive processes that can help to overcome compulsions.

PI_NAMEs: PRICE, REBECCA  (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acute;Animal Model;Animals;Anxiety;Area;arm;Back;Behavior;Behavior assessment;Behavioral;behavioral outcome;Biological;Brain;brain behavior;Brain region;Chemosensitization;Chronic;clinically relevant;clinically significant;Cognition;cognitive process;cognitive testing;comparison group;compulsion;Compulsive Behavior;Computers;cost;Coupled;Data;design;Development;Disease;Distress;Dose;eating pathology;Equilibrium;Etiology;Exhibits;experimental study;Failure;flexibility;follow-up;Functional disorder;Funding;Future;Glutamates;Goals;Grooming;Habits;Homosynaptic Depression;Hour;Human;improved;indexing;Individual;Laboratories;Learning;Link;Literature;Measures;Mediating;Modeling;Mus;neural;Neurocognitive;neuroimaging;neuromechanism;neuroregulation;noninvasive brain stimulation;novel;Obsessive compulsive behavior;optogenetics;Participant;Pathway interactions;Patient Self-Report;Patients;Protocols documentation;psychologic;Randomized;Rattus;recruit;repetitive behavior;response;Rest;Role;Selective Serotonin Reuptake Inhibitor;Services;Shock;skills;substance use;Symptoms;Testing;Theoretical model;therapy development;Time;tool;Training;Transcranial magnetic stimulation;Translating;translational model;translational study;Translations;Uncertainty;Variant;Ventral Striatum;Visit;Work

PROJECT_TITLE: Experimental Manipulation of OFC Function and Behavioral Context: Towards an Integrative Translational Model of Compulsive Behaviors

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_DEPT: GENETICS

PHR: NARRATIVE  Cancer is primarily a disease of old age, however very little is known about how cancer cell-intrinsic, microenvironmental, and systemic age-related changes impact cancer initiation and growth. We will permute cancer cell age and genotype, as well as microenvironment and host age, to gain an unprecedented understanding of the contribution of these factors to lung cancer initiation and growth. Ultimately, our findings could have important implication for cancer prevention, detection, and treatment.

PI_NAMEs: WINSLOW, MONTE MEIER (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Adult;Age;age effect;age related;age related changes;aged;Aging;Architecture;Bar Codes;Biology;cancer cell;Cancer Cell Growth;cancer initiation;Cancer Model;cancer prevention;carcinogenesis;Carcinogens;cell age;Cell Line;Cells;Coupled;CRISPR/Cas technology;Data;Dedications;Detection;Disease;DNA Sequence Alteration;Environment;Event;experimental study;gene function;Gene Silencing;Genes;Genetically Engineered Mouse;Genome engineering;Genomics;Genotype;Goals;Growth;hallmarks of aging;Human;human cancer mouse model;human old age (65+);in vivo;Individual;insight;KRAS2 gene;laboratory experience;Lung Adenocarcinoma;lung cancer cell;lung carcinogenesis;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Methods;microorganism;Modeling;Molecular;mouse model;Mus;Mutation;Normal tissue morphology;novel;old mice;Parabiosis;Pathway interactions;Positioning Attribute;Research Personnel;single cell analysis;synergism;System;theories;Tissues;Transplantation;tumor;tumor growth;tumor initiation;tumor microenvironment;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;Whole Organism

PROJECT_TITLE: Dissecting the interplay between aging, genotype and the microenvironment in lung cancer


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Natural Products;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Hypoxic-ischemic encephalopathy (HIE) is common in infants and, despite the use of therapeutic hypothermia, often results in death or neurodevelopmental impairment. This proposal will investigate caffeine as an adjunct therapy for HIE by examining how drug disposition is altered due to hypothermia. Population pharmacokinetic modeling and dose simulations will be performed using pilot data and a dose-validation clinical trial will be conducted to confirm optimal caffeine dosing.

PI_NAMEs: JACKSON, WESLEY M (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adjuvant Therapy;Age;Animal Model;Apnea;Birth Weight;Blood flow;Brain;Brain Injuries;Caffeine;career;career development;Cessation of life;Childhood;Clinical Pharmacology;Clinical Trials;Clinical Trials Design;Cohort Studies;Conduct Clinical Trials;Creatinine;Critical Illness;Cytochrome P450;Data;design;Development;Development Plans;Disease;Dose;drug development;drug disposition;Drug Kinetics;Drug usage;Enrollment;Environment;Enzymes;experience;Faculty;Future;Goals;Health;Hospitals;Human;Hypoxia;improved;improved outcome;Infant;Injury;Investigational New Drug Application;Lead;Live Birth;Mediating;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;methylxanthine;model development;mortality;multidisciplinary;natural hypothermia;neonatal hypoxic-ischemic brain injury;Neonatology;Neurodevelopmental Impairment;neuroprotection;novel therapeutics;open label;operation;Organ;Outcome;Pharmaceutical Preparations;pharmacokinetic model;Phase;pilot trial;Placebo Control;Population;postnatal;Pre-Clinical Model;preterm newborn;prevent;Procedures;prospective;protective effect;Public Health;Randomized;Recording of previous events;Regimen;Research;research and development;Research Personnel;Resources;Safety;Serum;simulation;Site;skills;Structure;Therapeutic;Therapeutic Uses;Training;Treatment Protocols;United States National Institutes of Health;Validation;Vulnerable Populations;Weight

PROJECT_TITLE: Dose Optimization for Novel Drugs for Infants with Hypoxic-Ischemic Encephalopathy

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Eye Disease and Disorders of Vision;Genetics;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Volatile toxic industrial materials (TIMs) have potential to cause large-scale injury and death, highlighting the public health risks associated with storage and transport of these economically important chemicals. The cornea of the eye is highly susceptible to TIM vapor exposure; however, corneal toxicities and long-term outcomes remain poorly characterized. In addition to identifying toxicological mechanisms and expanding our understanding of chemotoxic injury in the cornea, these studies will inform risk assessments and exposure management plans for these highly reactive TIMs and related chemotoxic agents.

PI_NAMEs: MCNUTT, PATRICK MICHAEL (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: absorption;Accidents;Acute;adduct;Autopsy;Biological;Biological Assay;Biological Markers;Bulla;Cadaver;Cataract;Cell Death;Cessation of life;Chemical Injury;chemical threat;Chemicals;chemokine;Clinical;clinical examination;Cornea;corneal epithelial wound healing;corneal epithelium;Corneal Injury;corneal regeneration;corneal scar;covalent bond;cytokine;cytotoxic;cytotoxicity;Development;Disabling;DNA;Dose;epithelium regeneration;experience;Exposure to;Eye;Eye Injuries;Functional disorder;Gene Expression;Genes;Genetic Transcription;Goals;healing;Histologic;Human;in vivo;India;Industrialization;Inflammatory;Injury;innovation;Laboratories;Lesion;Liquid substance;Long-Term Effects;Longitudinal Studies;mass casualty;Measures;Methods;methyl isocyanate;Modeling;Molecular;Molecular Target;Monitor;Mustard Gas;neovascularization;Optical Coherence Tomography;Organ Culture Techniques;Oryctolagus cuniculus;Outcome;Pathology;Pathway interactions;Penetration;Physiological;Poison;Population;Predisposition;Productivity;Prognosis;programs;Property;Proteins;Proteome;Public Health;Recovery;Research Personnel;response;response to injury;Risk;Risk Assessment;RNA;Route;small molecule;Structure;Survivors;System;Therapeutic;therapeutic target;Thick;Tissue-Specific Gene Expression;Tissues;Toxic effect;Toxicology;transcriptome;transcriptomics;Translating;vapor;Vesicants;Vision;Visual impairment;Volatilization;wound healing

PROJECT_TITLE: Toxic Mechanisms of Vesicating Chemicals in the Eye


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: RELEVANCE TO PUBLIC HEALTH Aging is a complex process that drives increased cancer risk in tissues throughout the body, including the blood system. To understand why aged individuals have higher risk of developing blood cancers, there is a vital need to understand the mechanisms by which aging contributes to clonal expansion and transformation. This research is relevant to public health because it will provide mechanistic insights into effective therapeutic strategies to target clonal evolution, attenuate pathophysiology promoted by clonal expansion, and intercept malignant transformation.

PI_NAMEs: LEVINE, ROSS L;TROWBRIDGE, JENNIFER JEAN (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Age;age related;age-related disease;aged;Aging;aging population;aging process;aging related;Alleles;Attenuated;Automobile Driving;Biological;Blood;cancer initiation;cancer risk;Cell Compartmentation;Clonal Evolution;Clonal Expansion;Coculture Techniques;Complex;Credentialing;CSF1 gene;cytokine;Cytokine Signaling;Data;Dependence;Disease;DNMT3a;DNMT3a mutation;Engineering;Epigenetic Process;epigenetic regulation;fitness;Functional disorder;functional genomics;Goals;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;hematopoietic stem cell expansion;Hematopoietic stem cells;Hematopoietic System;high risk;Human;human tissue;in vivo;Incidence;Inflammaging;Inflammation;Inflammation Mediators;Inflammatory;innovation;insight;Intercept;Knock-in Mouse;leukemia;leukemic transformation;Link;Literature;Malignant - descriptor;Malignant Neoplasms;middle age;Modeling;Molecular;mouse model;Mus;mutant;Mutation;new therapeutic target;normal aging;novel;old mice;Patients;Phenotype;pre-clinical;pressure;prevent;pro-aging;Process;Production;Public Health;Research;response;Risk;Risk Factors;Role;Sampling;Signal Transduction;small molecule inhibitor;Somatic Mutation;stem cell expansion;stem cell survival;System;Testing;Therapeutic Studies;Therapeutic Use Study;therapeutically effective;Tissues

PROJECT_TITLE: Assessing the Interplay Between Inflammatory Signaling and Epigenetic Dysregulation in Age-associated Clonal Hematopoiesis and Leukemia Initiation


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

PHR: PROJECT NARRATIVE Delays and missed opportunities for timely treatment contribute significantly to global disparities in cervical cancer in low- and middle-income countries {LMICs) compared to high-income countries, yet little is known about how best to increase adoption of evidence-based cancer care in LMICs. This project will help to fill this critical research gap by testing the effectiveness of patient- and system-level strategies on timeliness of care among females diagnosed with cervical cancer in Botswana. The results of this project will yield fundamental knowledge about how to improve and sustain timely cancer care in Botswana, and, if successful, identify strategies that can be easily translated to address other areas of cancer control across LMICs.

PI_NAMEs: GROVER, SURBHI  (contact);RENDLE, KATHARINE A.

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Address;Adoption;AIDS related cancer;Appointments and Schedules;Area;arm;Behavior;behavioral economics;Botswana;cancer care;Cancer Control;Cancer Control Research;cancer diagnosis;cancer therapy;care coordination;Caring;Cervical Cancer Screening;Cessation of life;Clinic;Clinical;clinical care;cohort;Communication;comparative;Complex;Consolidated Framework for Implementation Research;contextual factors;Country;Data;design;Developing Countries;Diagnosis;Diagnostic Procedure;Disparity;Early Diagnosis;Effectiveness;effectiveness evaluation;effectiveness testing;Ensure;Evaluation;evidence base;Evidence based practice;Evidence based treatment;Failure;Female;Goals;Health Services Accessibility;High Prevalence;HIV;HIV diagnosis;Hybrids;implementation cost;implementation outcomes;implementation strategy;implementation trial;improved;Incidence;Income;Individual;innovation;Intervention;Interview;Knowledge;low and middle-income countries;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Methods;Modeling;mortality;Motivation;National Cancer Institute;Newly Diagnosed;Outcome;outreach;outreach clinics;Pathology;patient navigation;patient outreach;Patients;Persons;Prevention;Preventive;Public Health;Publishing;Randomized;Recommendation;Research;Resource-limited setting;response;screening;Sequential Multiple Assignment Randomized Trial;Shapes;success;Surveys;System;system-level barriers;Testing;Theoretical model;Touch sensation;Translating;trial design;Visit;women's diagnosis

PROJECT_TITLE: Thibang Diphatlha: Testing adaptive strategies to close the gap from cervical cancer diagnosis to treatment in Botswana