NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Antimicrobial Resistance;Bioengineering;Biotechnology;Brain Disorders;Data Science;Dementia;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative Science has been driven by human intuition and reductionist models, yet these approaches can be overwhelmed by the level of complexity commonly found in biology. We recently bridged fundamental gaps enabling computational approaches to address this challenge, including developing a new type of artificial neural network that can distil human-understandable and generalizable rules from complex patterns. We will apply these approaches to discover how protein and RNA sequence encodes structure and function, including for the large class of intrinsically disordered proteins that control cell fate and disease but are difficult to experimentally characterize.

PI_NAMEs: LIN, MILO  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Acceleration;Address;Amino Acid Sequence;Amyloid beta-Protein;Antibiotic Resistance;Antibiotics;artificial neural network;Automobile Driving;Behavior;beta-Lactamase;Biological Assay;Biology;Black Box;Cell Fate Control;Collaborations;Complex;Computing Methodologies;Data;Data Set;deep learning;Dimensions;Directed Molecular Evolution;Disease;disease diagnosis;experimental study;Foundations;Future;Goals;Health;high dimensionality;Human;Informatics;insight;Intuition;invention;large datasets;Learning;Libraries;Liquid substance;Methods;Modeling;molecular dynamics;monomer;mutant;Network-based;neural network;Neurobiology;Neurodegenerative Disorders;neurotoxic;Patients;Pattern;Peptide Library;Peptides;Pharmaceutical Preparations;Physics;protein aggregation;Proteins;Resources;RNA;RNA Sequences;Running;Sampling;Science;self assembly;simulation;Structure;tau aggregation;tau Proteins;Time;training data;Work

PROJECT_TITLE: Discovering interpretable mechanisms explaining high dimensional biomolecular data


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CLEVELAND

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative This proposal aims to study the relationship between inflammation and cancer. Specifically we will investigate the pathogenic role of pro-inflammatory interleukin-17 in tumor progression and resistance to anti-cancer therapies including chemotherapy and checkpoint inhibitors. The completion of the proposal will inform the design of novel therapeutic strategies and identify potential therapeutic targets that improve the therapeutic response in otherwise refractory tumors.

PI_NAMEs: STAPPENBECK, THADDEUS S (contact)

PROJECT_TERMS: Animal Model;antagonist;anti-PD-1;anti-PD1 therapy;Automobile Driving;Award;Binding;cancer cell;cancer cell differentiation;cancer therapy;CD8-Positive T-Lymphocytes;Cells;Chemoresistance;chemotherapy;Chronic;Cisplatin;Collaborations;Collagen;cytokine;Data;Deposition;design;Development;Dissection;Environment;Epidermal Growth Factor Receptor;Exclusion;Fibroblasts;Genes;Genetic;Goals;Head and Neck Squamous Cell Carcinoma;HIF1A gene;Human;IL17 gene;Immune;Immune checkpoint inhibitor;Immunotherapy;improved;in vivo evaluation;Infiltration;Inflammation;Inflammatory;insight;Interleukins;Knowledge;Link;Malignant Neoplasms;MAPK7 gene;Mediating;Messenger RNA;Molecular;Mus;Myeloid-derived suppressor cells;neoplastic cell;novel therapeutic intervention;oxidation;Pathogenicity;Population;pre-clinical assessment;prevent;Process;Prognosis;programs;Proteins;Refractory;Reporting;Resistance;response;RNA Binding;Role;Shapes;Signal Transduction;single cell analysis;skin squamous cell carcinoma;Solid Neoplasm;Squamous cell carcinoma;Standardization;Statistical Data Interpretation;stem;stem cells;stemness;Stromal Cells;synergism;Testing;Therapeutic;therapeutic target;therapy resistant;tool;Transcript;transcriptome;transcriptomic profiling;Transforming Growth Factor beta;Translations;treatment response;tumor;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Work;wound healing

PROJECT_TITLE: IL-17-driven mechanisms for tumor progression and resistance to therapies


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric

ORG_CITY: COLUMBIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Friendships play an important role in adolescent development and may have the potential to mitigate or exacerbate the impact of child maltreatment on future adverse outcomes. The proposed research is relevant to public health because it is expected to increase our understanding of how maltreated adolescents’ friendships impact their development, which will elucidate new mechanisms for interrupting the negative sequelae associated with child maltreatment. This is relevant to NIH’s mission because findings can ultimately inform interventions with the potential to reduce the incidence of psychopathology and promote greater quality of life, thereby alleviating the economic burden of this pervasive societal problem.

PI_NAMEs: BROWN, MICHELLE PATRICE (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: academic preparation;Address;Adolescence;Adolescent;Adolescent Development;Adult;Adverse event;adverse outcome;Anger;antisocial behavior;Behavior;Biological;Buffers;career development;Caregivers;Child;Child Abuse and Neglect;child depression;Child Development;Clinical Trials;Code;college;Conflict (Psychology);Data;Data Analyses;Data Collection;Development;Economic Burden;emotion dysregulation;Environment;Exhibits;experience;Faculty;follow-up;Fostering;Friends;Friendships;Funding;Future;Goals;Grant;Health;Hour;improved;Incidence;Individual;Influentials;innovation;Institution;Interruption;Intervention;intimate behavior;Investigation;job market;Knowledge;Laboratories;Learning;Literature;Longitudinal Studies;longitudinal, prospective study;maltreatment;Mediating;Medicine;Mentors;Mentorship;Methodology;Methods;Mission;Modeling;Nature;next generation;Outcome;Parents;Participant;peer;peer victimization;Phase;Physiological;Play;Population;Procedures;Productivity;psychologic;Psychological reinforcement;Psychopathology;Psychophysiology;Public Health;Publishing;Quality of life;Randomized;recruit;Regulation;Reporter;Reporting;Research;Research Design;Research Personnel;Resources;Risk;Risk Behaviors;Role;skill acquisition;skills;social;Socialization;Stress;stressor;Techniques;Testing;Training;Training Activity;Trust;United States National Institutes of Health;Update;vulnerable adolescent;Writing;Youth

PROJECT_TITLE: Beneficial or Fostering Future struggles (B.F.F.s)? Characterizing the Role of Friends in the Developmental Trajectory of Maltreated Adolescent

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cancer

PHR: PROJECT NARRATIVE The Administrative Core provides administrative support to the Program Project to enable efficient cooperation among constituent projects and to serve as the interface between the Program Project, the advisory boards and the NCI.

PI_NAMEs: STARK, GEORGE ROBERT (contact)

PROJECT_TERMS: Animal Model;Animals;Cancer Biology;Clinic;Communication;cytokine;data management;data sharing;Dissection;Expenditure;Goals;Individual;Leadership;Molecular;operation;organizational structure;Preparation;Program Evaluation;programs;Progress Reports;Protocols documentation;Research Institute;Research Project Grants;Services;Structure;tumor microenvironment

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

PHR: Project Narrative Core B is part of a Program Project that aims to investigate how intratumor inflammation affects tumor progression and responses to therapy. Core 1 is designed to facilitate the testing of novel therapeutic strategies in preclinical cancer models, to enable uniform sample processing for characterizing intratumor inflammation and to foster interactions among the constituent projects including analytics assistance.

PI_NAMEs: HAMILTON, THOMAS A. (contact)

PROJECT_TERMS: Address;Affect;Animal Model;Autologous;Bioinformatics;Cancer Model;cancer type;CD8-Positive T-Lymphocytes;Cell surface;cell type;Cells;Charge;checkpoint therapy;chemotherapy;Consultations;Crossbreeding;cytokine;Cytokine Network Pathway;Cytokine Signaling;Data;Data Analyses;Dendritic Cells;design;Detection;Dissection;Dose;Ensure;experience;experimental study;Fibroblasts;Flow Cytometry;Fluorescence-Activated Cell Sorting;fluorophore;Fostering;Gene Modified;Genetically Engineered Mouse;Goals;Growth;Head and Neck Squamous Cell Carcinoma;Human;humanized mouse;IL17 gene;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immunocompetent;Immunocompromised Host;Immunotherapy;improved;in vivo;in vivo evaluation;Individual;Inflammation;Inflammatory;inflammatory milieu;Infrastructure;instrumentation;Interferon-beta;Interferons;Kinetics;Knock-in Mouse;KRASG12D;Libraries;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant Neoplasms;Measures;member;Mission;Modeling;Molecular;mouse model;Mouse Strains;Mus;Myeloid Cells;novel therapeutic intervention;Outcome;Pathway interactions;patient derived xenograft model;Peripheral Blood Mononuclear Cell;pre-clinical;pre-clinical assessment;Procedures;programs;Protocols documentation;Research Personnel;Resistance;response;Role;Sampling;Services;Shapes;Signal Pathway;single cell sequencing;Standardization;STAT2 gene;Suspensions;Testing;Th1 Cells;Therapeutic;tissue preparation;Tissues;tool;Transcend;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Biology;Tumor Cell Line;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Tissue;tumor xenograft;Work;Xenograft Model

PROJECT_TITLE: Core B: Animal Model and Immunotyping Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Muscular Dystrophy;Rare Diseases

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Nucleo-cytoplasmic communication is an essential element of all eukaryotic lifeforms, including humans. Our goal is to provide the structural underpinning of the relevant machineries in the cell that facilitate and are involved in these processes, since such information leads to a mechanistic understanding and, most importantly, enables structure-guided drug design. Dysfunctional nucleo-cytoplasmic communication is at the core of diverse human diseases, including muscular dystrophies, cardiomyopathies, premature aging, and cancer.

PI_NAMEs: SCHWARTZ, THOMAS  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Cardiac;Cardiomyopathies;Cell Nucleus;Cell Physiology;Cells;Communication;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Cytoskeleton;Drug Design;Elements;Emery-Dreifuss Muscular Dystrophy;Eukaryotic Cell;Functional disorder;Genetic Materials;Genetic Transcription;Goals;grasp;Human;human disease;Individual;innovation;Life;Malignant Neoplasms;Maps;mechanotransduction;Membrane;Methods;Molecular;Muscular Dystrophies;Myopathy;Nuclear Envelope;Nuclear Pore Complex;Organelles;Positioning Attribute;Premature aging syndrome;Primary Dystonias;Process;Productivity;protein complex;Proteins;Resolution;skeletal;Structure;success;SWP29;Technology;Translations;X-Ray Crystallography

PROJECT_TITLE: Structure-Function of Nucleo-Cytoplasmic Communication

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR:  T cells are a vital component of the innate and adaptive immune response against pathogens and cancer and may play a particular role in colorectal cancer. Information is limited on how these cells, through their T cell receptor (TCR), recognize the physiological ligands that lead to an immune response and what other signals may modulate their activity. We seek to study the interaction of these T cells in humans, the lipid presenting, MHC-like molecule CD1d. Combined, our aims strive to elucidate the “rules of recognition” for these T cells and understand how these responses are involved in human disease.

PI_NAMEs: ADAMS, ERIN JUNE (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: adaptive immune response;Address;Adoption;Anti-Inflammatory Agents;antigen detection;Antigens;Autoimmunity;Binding;Biochemical;Biochemistry;Biological Assay;biophysical analysis;biophysical properties;Biophysics;Cancerous;CD1 Antigens;Cell Culture Techniques;cell growth;Cell Line;Cell Physiology;Cells;Clonal Expansion;Colon;Colorectal Cancer;colorectal cancer progression;Complex;Crystallization;cytokine;Data;Disease;Ensure;Epithelium;Foundations;Frequencies;functional status;Generations;Glycoproteins;Goals;Health;Human;human disease;Immune response;Immunity;Immunobiology;immunoregulation;In Vitro;Individual;Infection;Infectious Agent;Inflammatory;Innate Immune Response;innovation;insight;Institutional Review Boards;interest;Investigation;Laboratories;Ligands;Link;Lipids;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Memory;Molecular;Mus;pathogen;Peripheral;peripheral blood;permissiveness;Phenotype;Physiological;Play;Population;premalignant;professor;Protein Biochemistry;Protein Engineering;receptor;receptor binding;recruit;response;RNA;Role;Sampling;Shapes;Signal Transduction;Specificity;Stress;structural biology;Structure;success;Sulfoglycosphingolipids;System;T-Cell Activation;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Tissue Banks;Tissues;tool;Transcript;transcriptome sequencing;tumor;tumor microenvironment;tumorigenesis;Umbilical Cord Blood;Viral;Work;X-Ray Crystallography;γδ T cells

PROJECT_TITLE: Molecular and functional investigation of the role of CD1 in gamma delta T cell surveillance

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Childhood Obesity;Genetics;Infectious Diseases;Lung;Maternal Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: NARRATIVE Pre-pregnancy maternal obesity is associated with significant adverse health outcomes for the offspring including increased risk of severe neonatal infections and developing chronic diseases such as asthma and cardiovascular disease, which suggests a dysregulated immune system. Recent studies from our laboratory revealed significant changes in umbilical cord blood immune cells from babies born to obese mothers but the impact of maternal obesity on fetal immune cells remains poorly defined/understood. This application will carry out an in-depth investigation of maternal pre-pregnancy obesity-driven changes to the fetal immune cell populations and functions to contribute to the fundamental knowledge of the immune system development and identify potential interventions to address fetal immune dysregulations.

PI_NAMEs: MESSAOUDI, ILHEM  (contact);VARLAMOV, OLEG

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Adaptive Immune System;Address;Adipose tissue;Animal Model;Animals;antimicrobial;Asthma;Autoimmune Diseases;Biological Assay;Bone Marrow;Breeding;Cardiovascular Diseases;CD14 gene;CD34 gene;Cells;Cesarean section;Chronic Disease;chronic inflammatory disease;Classification;Clinical;Clinical Data;Clinical Research;Confounding Factors (Epidemiology);Data;Development;Disease;Early Intervention;Endocrinologist;Enterocolitis;Environment;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Escherichia coli;experimental study;Exposure to;Female of child bearing age;fetal;fetal blood;Fetal Development;Fetal health;fetal immunity;Fetal Liver;Fetal Tissues;Flow Cytometry;Genes;Genetic Transcription;Genomics;Gravid;Growth;Health;health of the mother;Hematopoiesis;Hematopoietic stem cells;Homeostasis;Host Defense;Immune;Immune system;Immunity;Immunologist;Incidence;Infection;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;innovation;insight;Intervention;Intestines;Investigation;Knowledge;Laboratories;Ligands;Liquid substance;Lung;Macaca mulatta;Macrophage;maternal condition;maternal obesity;Maternal-Fetal Exchange;Measures;Mediating;Metabolic;Metadata;microbial;Modeling;Molecular;monocyte;Mothers;Mus;Myelopoiesis;Natural Immunity;Necrotizing Enterocolitis;Neonatal;neonatal infection;neonate;Newborn Infant;nonhuman primate;obese mothers;Obesity;offspring;Outcome;Partner in relationship;pathogen;pathogenic bacteria;pathogenic virus;peripheral blood;Phagocytes;Phenotype;Population;Predisposition;Pregnancy;prepregnancy;prepregnancy obesity;progenitor;Reporting;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;response;Rest;Risk;Sepsis;Signal Transduction;single cell genomics;single-cell RNA sequencing;Site;Skeletal Muscle;Spleen;Splenocyte;Study models;success;Systems Biology;Systems Development;Techniques;Technology;Testing;Thinness;Third Pregnancy Trimester;time use;Tissues;Training;Umbilical Cord Blood;United States;Wheezing;Yolk Sac

PROJECT_TITLE: Maternal obesity and neonatal innate immunity


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Estrogen;Genetics;Human Genome;Infectious Diseases;Precision Medicine;Social Determinants of Health;Women's Health Research

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE Sex and gender differences are a combination of genetics, sex hormones, and other environmental regulators. In this work we explore how sex hormones and environmental regulation interact with variants on the sex chromosomes to impact the immune system and response to various viral and bacterial infections. To do this, we integrate a mouse model of genetic editing of the sex chromosome that is exposed to chronic infection with large scale data analysis of rodent and human sex and gender contributions to the immune system.

PI_NAMEs: KRAWCZYK, CONNIE ;PROKOP, JEREMY WILLIAM;TRICHE, TIMOTHY J. (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: adaptive immunity;Animal Model;Antibodies;Antibody Formation;Antigen Presentation;Atlases;Autoimmune Diseases;autoimmune thyroid disease;Autoimmunity;Bacterial Infections;biobank;Biological;Biological Assay;biological sex;Birth;Blood;Blood specimen;Cell Physiology;cell type;Cells;Cessation of life;Chromosome Mapping;Chromosome Pairing;Chronic;chronic infection;cis-female;Communicable Diseases;Compensation;conditional knockout;cost;COVID-19;Cytomegalovirus;Data;Data Analyses;data integration;Data Set;differential expression;differentiation in vitro;Disparity;Environment;Environmental Risk Factor;Epidemiology;Epigenetic Process;Equilibrium;Erythrocytes;Estrogens;Exposure to;Female;fighting;fitness;Four Core Genotypes;Gender;gender difference;Gender Identity;Gender Role;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Determinism;Genetic Models;genetic variant;Genetic Variation;genome-wide;Genomics;genotypic sex;Gonadal Steroid Hormones;Hematopoiesis;Hematopoietic;histone methylation;Histones;HIV risk;Hormonal;Hormones;Hospitalization;hospitalization rates;Human;human data;Human Genetics;human model;human old age (65+);Hypocellular Bone Marrow;Immune;immune function;Immune response;Immune system;Immunity;immunoregulation;Individual;infancy;infant infection;Infection;infectious disease model;Inflammatory;innovation;insight;Interferons;Investments;Knock-out;Knockout Mice;Knowledge;knowledge integration;large scale data;Lead;Link;Lupus;male;Mediator;Messenger RNA;Modeling;Molecular;Molecular Genetics;mouse model;Mus;Natural Immunity;nonbinary;novel;novel strategies;outcome prediction;paralogous gene;Pathway interactions;Phenotype;Population;precision medicine;proband;Production;protective effect;Quantitative Trait Loci;Regulation;Resolution;Resources;Respiratory Syncytial Virus Infections;response;Risk;Rodent;Rodent Model;Role;Scleroderma;sex;Sex Chromosomes;Sex Differences;sexual dimorphism;Shapes;Sjogren's Syndrome;Societies;synergism;T-Lymphocyte;Testing;Testosterone;Thinking;Tissues;tool;Trans-Omics for Precision Medicine;Transcript;transcriptomics;transgender women;Tuberculosis;Vaccination;Validation;Variant;Viral;Virus Diseases;women versus men;Work

PROJECT_TITLE: The roles of genetics, hormones, and gender in sexually dimorphic immune response


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Loma Linda

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: LOMA LINDA UNIVERSITY

ORG_STATE: CA

PHR: Acute myeloid leukemia (AML) contributes to 32% of all adult leukemia and remains one of the most clinically devastating cancers. Currently, AML diagnosis, risk stratification and treatment selection are mainly based on cytogenetic abnormalities, which suffers from low sensitivity and low resolution. To overcome this technical hurdle, we propose to use single-cell RNAseq with microfluidic devices to generate a molecular version of cytogenetic profile including all mRNA abnormalities from a large number of cells.

PI_NAMEs: ZHONG, JOHN  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult Acute Myeloblastic Leukemia;adult leukemia;Alternative Splicing;Antibodies;Benchmarking;bioinformatics pipeline;Biological Assay;Bone Marrow;Cell fusion;Cell Line;Cells;Cessation of life;Chemoresistance;chemotherapy;Chromosome abnormality;Clinical;Complementary DNA;computational pipelines;Conduct Clinical Trials;Cytogenetic Analysis;Cytogenetics;Data;Data Set;Detection;detection limit;Diagnosis;Diagnostic;Disease;droplet sequencing;drug relapse;Drug resistance;drug resistance development;Early identification;Flow Cytometry;fusion gene;Gene Expression Profile;Gene Rearrangement;Genetic;Genomics;Goals;improved;Length;leukemia relapse;leukemia treatment;Leukemic Cell;Malignant Neoplasms;Measures;Messenger RNA;Metaphase;Microfluidic Microchips;Microfluidics;Molecular;Names;nanopore;new technology;next generation;Outcome;Patients;Pharmaceutical Preparations;Play;Prognosis;Relapse;Reporting;Research Personnel;Resolution;risk stratification;Role;Sampling;Selection for Treatments;Sensitivity and Specificity;single-cell RNA sequencing;Spliced Genes;Survival Rate;survivin;Techniques;Technology;therapeutic target;transcriptome sequencing;translational goal;treatment response

PROJECT_TITLE: Large scale single-cell gene rearrangement detection with a microfluidic device

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Neurodegenerative

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project narrative  Essential cellular processes common to all cells are often controlled by GTPases within the ARF family and dysfunction in these regulatory systems result in human diseases ranging from cancer, heart disease, neurodegeneration, retinal degeneration, and deafness. We propose to determine molecular mechanisms by which these GTPases act and consequences at the cellular level when they dysfunction. As a result, we hope to discover fundamental aspects of cell biology that are relevant to understanding and treating a host of human conditions and also allow us and others to decipher fundamental concepts involved in cell regulation.

PI_NAMEs: KAHN, RICHARD A (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Arl proteins;Biochemical;Biological;Cell Line;Cell Physiology;Cells;Cellular biology;Centrosome;Cilia;ciliopathy;cilium biogenesis;Collection;Cytoskeleton;deafness;Energy Metabolism;Enzymatic Biochemistry;Family;Functional disorder;Genetic;genome editing;Guanosine Triphosphate Phosphohydrolases;Heart Diseases;Human;human disease;In Vitro;insight;Intervention;Knock-out;Link;Malignant Neoplasms;member;Membrane Protein Traffic;Molecular;Nerve Degeneration;novel;Pathway interactions;Phylogenetic Analysis;Protein Biochemistry;Regulation;Retinal Degeneration;Signal Transduction;Signaling Protein;System

PROJECT_TITLE: Molecular mechanisms of ARF family GTPases

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLORADO SPRINGS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Different next-generation, high-throughput sequencing technologies have been developed to capture chromosomal interactions. The ability to analyze the three-dimensional (3D) chromatin organization at a greater level of resolution than cytogenetic methods has significantly increased as a result of this advancement. The primary objective of this research is to develop robust algorithms to decipher the spatial genome organization and 3D folding that occurs within the cell.

PI_NAMEs: OLUWADARE, OLUWATOSIN  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Architecture;Bioinformatics;Biological Process;Cells;Chromatin;chromosome conformation capture;Chromosome Structures;Chromosomes;Communities;complex data;Computational algorithm;convolutional neural network;cost;Cytogenetic Analysis;Data;Development;disease diagnosis;Enhancers;Epigenetic Process;Gene Expression;Genes;Genetic;Genome;Genomics;Graph;Hi-C;High-Throughput Nucleotide Sequencing;Human;human disease;innovation;Interdisciplinary Study;Light;machine learning model;Mammalian Chromosomes;member;Methodology;Methods;model generalizability;Modeling;Molecular Conformation;next generation;novel;Population;Positioning Attribute;Prevention;Productivity;programs;reconstruction;Research;Research Personnel;Resolution;restriction enzyme;Rewards;Structural Models;Structure;Techniques;Technology;three dimensional structure;three-dimensional modeling;Training;Work

PROJECT_TITLE: Can one size fit all? - High-Resolution 3D Genome Spatial Organization Inference with Generalizable Models

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biomedical Imaging;Infectious Diseases;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PI_NAMEs: DELANEY, LAUREN JO (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adherence;Antibiotic Therapy;Antibiotics;antimicrobial;Area;Bacteria;Bacterial Infections;Bolus Infusion;Career Mobility;Clinical;Combined Antibiotics;disability;drug resistant pathogen;Ensure;Excision;experience;Gram-Negative Bacteria;Hospitalization;Hydrogels;Implant;In Vitro;in vivo Model;Infection;Infection prevention;infection rate;innovation;Kinetics;Left;Microbial Biofilms;Modality;mortality;novel;Operative Surgical Procedures;pain reduction;pathogen;Patients;Perioperative;persistent bacteria;Postoperative Period;Powder dose form;prevent;prophylactic;Prophylactic treatment;Research;Research Personnel;Risk Reduction;Site;skills;spatiotemporal;Spinal;Spinal Fusion;Spine surgery;System;Time;Tobramycin;Training;Translating;ultrasound;Vancomycin;Work;wound

PROJECT_TITLE: Ultrasound-Triggered Prophylaxis as a Novel Paradigm for Preventing Spinal Infection


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative This proposal seeks develops new methods for drug discovery, applying these to questions of current biological interest. A practical outcome are tools useful to chemical biologists and drug discovery scientists, and particular molecules that can illuminate new aspects of cell signaling. A small number of these molecules may be leads towards new drugs.

PI_NAMEs: SHOICHET, BRIAN K (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TITLE: Development and Testing of New Computational Methods for Ligand Discovery and Mechanism


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Mental Health;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Having a child is a fundamental human experience; yet the extent to which women and couples experience infertility (the inability to conceive a pregnancy within 1-2 years of trying) is a neglected area of research, particularly in sub-Saharan Africa. The centrality of motherhood to women’s identity and societal value in these settings makes it a public health priority to understand the scale and negative repercussions of infertility, as well as the role of associated stigma and fear in exacerbating these effects. The proposed research will improve infertility estimation in low-resource settings and develop new psychometrically valid quantitative measures to inform strategies to reduce infertility-related stigma and fear.

PI_NAMEs: BELL, SUZANNE O'DEA (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;advanced analytics;Adverse effects;adverse outcome;Africa South of the Sahara;aged;Area;Award;Behavior;care seeking;career;Child;cognitive testing;Communities;Contraceptive Agents;Contraceptive methods;Country;Couples;Development;Dimensions;emotional abuse;Etiology;experience;Exposure to;Fertility;Fertility Study;Focus Groups;Fright;Funding;Future;Goals;Grant;Health;Health behavior;Health Care Seeking Behavior;health disparity;Hospitals;Human;improved;Individual;Infertility;Infertility study;infertility treatment;innovation;instrument;Intervention;Interview;Knowledge;Literature;Location;Longitudinal Studies;low and middle-income countries;low income country;Marriage;Measurement;Measures;men;Mentors;Mentorship;Methods;Modeling;Monitor;motherhood;National Institute of Child Health and Human Development;neglect;Outcome;Perception;Performance;Personal Satisfaction;physical abuse;Population;population based;Population Dynamics;Poverty;Pregnancy;Prevalence;prevent;Prevention;programs;psychological distress;Psychometrics;public health priorities;Qualitative Methods;reproductive;Reproductive Health;Research;Research Personnel;Research Priority;Research Technics;Resource-limited setting;Resources;Role;Sampling;secondary infertility;Social isolation;Social Sciences;social stigma;Suicide;Surveys;Techniques;Testing;Training;Training Activity;Uganda;Uncertainty;unintended pregnancy;United States National Institutes of Health;Unsafe Sex;Variant;Woman;Women's Health;Work;Writing

PROJECT_TITLE: Advancing Understanding and Measurement of Infertility, Related Fears and Stigma, and Associated Consequences in Low-Resource Countries

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

PHR: PROJECT NARRATIVE Despite patients with lower grade glioma benefit from better survival, injury from tumor growth and consequence of treatment, such as radiation therapy, often leads to impaired cognition and quality of life. The proposed study will investigate patients with lower grade astrocytoma using a multimodality MR protocol to assess the tumor burden, cognitive functioning, and quality of life. The results of the proposed study will be critical for developing effective treatment strategies to improve quality of life in lower grade astrocytoma.

PI_NAMEs: GORDON, JEREMY WILLIAM;LI, YAN  (contact);VILLANUEVA-MEYER, JAVIER

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Age;Anatomy;Astrocytoma;Biological Markers;Blood Volume;Brain;brain abnormalities;Brain Neoplasms;Carbon;Cell Respiration;Cerebrum;Clinical;clinical examination;Clinical Management;Clinical Research;Cognition;cognitive function;Creatine;Data;Decision Making;Diagnosis;Diffusion;early detection biomarkers;Edema;effective therapy;Evaluation;Excision;experience;first-in-human;Functional Magnetic Resonance Imaging;Glioma;Gliosis;Glutamates;Glycolysis;Grant;Image;image guided;imaging study;Impaired cognition;Impairment;improved;Infrastructure;Injury;interest;Intervention;Lesion;Location;Magnetic Resonance Imaging;Measures;Metabolic;metabolic imaging;Metabolism;Modeling;Monitor;multimodal neuroimaging;multimodality;Mutation;N-acetylaspartate;neoplastic cell;Neurocognitive;Neurocognitive Deficit;Neurons;novel;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Perfusion;Physiological;Positioning Attribute;pre-clinical;Productivity;Protocols documentation;Protons;Publications;Pyruvate;Quality of life;Radiation therapy;real-time images;Recording of previous events;Recurrence;Recurrent tumor;regional difference;Reproducibility;Research;Research Design;response;Rest;Risk;Scanning;Schedule;Scientist;Severities;spectroscopic imaging;survival outcome;survival prediction;Technology;temozolomide;Testing;Time;Tissue Sample;Tissues;treatment effect;Treatment Protocols;treatment response;treatment strategy;tumor;Tumor Biology;Tumor Burden;tumor growth;Tumor Volume;United States National Institutes of Health;volunteer;white matter;Work

PROJECT_TITLE: Multimodality Neuroimaging Evaluation of Cognitive Functioning in Lower Grade Astrocytoma

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Two fundamental, but mechanistically interdependent, processes that drive cancer development are genetic mutations (genome instability) and epigenome reprogramming (epigenome instability). Leveraging strong support from the Herbert Irving Comprehensive Cancer Center at Columbia University and the expertise of 25 outstanding faculty mentors, we propose to create the first Genome and Epigenome Integrity in Cancer (GEIC) Training Program to foster a group of next generation scientists with diverse backgrounds who will lead in the discovery of mechanisms underlying genome and epigenome instability in cancer and in the translating these discoveries into future therapeutic interventions of cancer.

PI_NAMEs: SYMINGTON, LORRAINE S;ZHANG, ZHIGUO  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: epigenome;Genome;Malignant Neoplasms

PROJECT_TITLE: Genome and Epigenome Integrity In Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Genetics

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE  Iron-sulfur DNA helicases play a critical role in human health by maintaining genome stability. There are four iron-sulfur helicases in humans, and mutations in the genes encoding each are associated with hereditary disorders that are typified by genomic instability and a predisposition to cancer. This proposal will define biochemical and molecular mechanisms by which this important family of DNA helicases function by investigating a newly discovered family member in an Escherichia coli model system.

PI_NAMEs: BLOOM, LINDA B (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: 2'-Deoxythymidine;Amino Acid Sequence;ATP Hydrolysis;Binding Sites;Biochemical;Biological Assay;Biological Models;Bypass;Cell Physiology;Cells;Cellular Assay;Chimeric Proteins;citrate carrier;Collaborations;Complex;Disease;Dissociation;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA Polymerase III;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA-Directed DNA Polymerase;Elements;Environment;Enzymes;Escherichia coli;experimental study;Family;Family member;Genes;Genetic;Genetic Diseases;Genome Stability;Genomic DNA;Genomic Instability;Goals;Health;helicase;Hereditary Disease;Holoenzymes;Human;In Vitro;in vivo;Iron;Kinetics;Laboratories;Lesion;Link;Malignant Neoplasms;Measures;member;Modeling;Molecular;Mutagenesis;Mutation;novel;Oxygen;Pathology;Pathway interactions;Play;Polymerase;polypeptide;Predisposition;preference;prevent;protein complex;protein protein interaction;Proteins;Reagent;repaired;replicase;Role;Single-Stranded DNA;Site;stoichiometry;Structure;Sulfur;Testing;Water;Work;Y protein

PROJECT_TITLE: Mechanisms and Functions of Iron-Sulfur Helicases in DNA repair

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Palliative Care;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative/Public Health Relevance Patients with severe lung problems (“acute respiratory failure”) who require life support treatments like ventilators often cannot speak for themselves, therefore their families and intensive care unit (ICU) clinicians should ideally work together to make medical decisions on their behalf in a process known as shared decision making. We know from outpatient clinic settings that shared decision making happens less frequently with Black compared to White patients, but this has not been studied in the ICU among patients with acute respiratory failure, therefore no tools currently exist to support ICU clinicians to engage Black families in shared decision making. In this study, we will document the reasons for racial disparities in shared decision making for patients with acute respiratory failure, and we will adapt an existing shared decision making tool to help ICU clinicians better engage Black families in shared decision making about acute respiratory failure.

PI_NAMEs: ASHANA, DEEPSHIKHA CHARAN (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute respiratory failure;Address;Ambulatory Care Facilities;Award;black patient;Black race;burnout;career development;Caring;Cessation of life;Clinical Trials;Collaborations;comparative;Complex;Critical Care;Critical Illness;Data;Databases;Decision Making;Dedications;design;Disparity;effectiveness outcome;Emotional;Environment;Epidemiology;Equity;experience;Family;Family member;Family Physicians;Feasibility Studies;feasibility testing;Feedback;Focus Groups;follow-up;Genetic Transcription;Goals;Health Disparities Research;health management;Health system;Hospitals;human centered design;improved;Individual;Intensive Care Units;Intervention;Interview;Knowledge;Length of Stay;Life;Lung;Measures;Mechanical ventilation;Medical;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;method development;Methods;Multi-Institutional Clinical Trial;National Heart, Lung, and Blood Institute;Outcome;Outpatients;Palliative Care;Patient Care;Patient Preferences;Patients;Physicians;preference;pressure;Process;Prognosis;prognostic;psychological distress;psychological outcomes;Public Health;public health relevance;racial disparity;randomized, clinical trials;recruit;Reporting;Research;research and development;Research Personnel;Resources;Respiratory Failure;shared decision making;skills;Structure;Testing;therapy development;Time;tool;Training;Transcript;Universities;Ventilator;Work

PROJECT_TITLE: Racial disparities in shared decision making for patients with acute respiratory failure

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Mental Health;Neurodegenerative;Neurosciences;Rehabilitation

ORG_DEPT: NEUROLOGY

PHR: Project Narrative  Alzheimer’s Disease (AD) has been shown to be a multifaceted disease with different phenotypes (variants) according to atrophy patterns; the aphasic variant of AD with left-hemisphere atrophy onset, also coined as logopenic variant primary progressive aphasia (lvPPA) and in this project PPA-AD, is the most common PPA for which there are no effective treatments. Transcranial direct current stimulation (tDCS), a type of noninvasive neuromodulation technique, has shown to be effective when combined with speech-language therapy for the treatment of naming and spelling deficits in PPA, but it is not understood how to maximize treatment effects, i.e., induce generalization of improvement to other than trained tasks to achieve clinical significance. The proposed project addresses this gap by comparing the effects of tDCS applied to brain networks that underly several language-specific vs. executive cognitive functions, and, thus, translates network neuroscience to neurorehabilitation to maximize the benefits of tDCS in the treatment of a devastating neurodegenerative disease.

PI_NAMEs: TSAPKINI, KYRANA  (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Address;Adjuvant;Affect;Aftercare;Alzheimer's Disease;Alzheimer's disease pathology;American;Anodes;Anomia;Aphasia;Area;Atrophic;behavior prediction;Behavior Therapy;Biological Markers;biomarker identification;Blood;Brain;brain pathway;brain volume;Caregiver Burden;Cessation of life;Characteristics;Clinical;Clinical Research;clinically significant;Cognitive;Cognitive deficits;cognitive function;cognitive performance;Coin;Combined Modality Therapy;comparative efficacy;Controlled Clinical Trials;cost;cost effective treatment;Coupled;COVID-19 pandemic;Development;Diffusion Magnetic Resonance Imaging;disability burden;Disease;Dorsal;Double-Blind Method;effective therapy;Etiology;executive function;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Glutathione;Impairment;improved;Individual;Inferior frontal gyrus;Intervention;Investigation;Language;Language Disorders;language impairment;language outcome;Language Therapy;Left;Magnetic Resonance Spectroscopy;Measures;Membrane Potentials;Memory impairment;Modeling;Monitor;Names;Nerve Degeneration;neural;Neurodegenerative Disorders;neuroimaging;neurological rehabilitation;Neuronal Plasticity;Neurons;neuroregulation;Neurosciences;Neurotransmitters;novel;Oral;Outcome;outcome prediction;Oxidative Stress;Pathology;Pattern;Performance;Perfusion;perfusion imaging;Pharmacological Treatment;Phenotype;phonology;Physiological;post intervention;predicting response;Prefrontal Cortex;Primary Progressive Aphasia;Probability;Progressive Aphasias;Randomized Controlled Clinical Trials;Research;Rest;sex;Short-Term Memory;Sleep;Speech;spelling;stroke-induced aphasia;Structure of supramarginal gyrus;Symptoms;Synaptic Transmission;targeted treatment;Techniques;Testing;Therapeutic;Time;Training;transcranial direct current stimulation;Translating;treatment effect;treatment research;Update;Variant;verbal;Verbal Learning;white matter;Writing

PROJECT_TITLE: Targeting language-specific and executive-control networks with transcranial direct current stimulation in aphasic AD

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health

PHR: PROJECT NARRATIVE The Nexus Scholars Program will provide short courses, mentoring, and applied research experiences to support the development of the next generation of investigators working at the intersection of HIV-related biomedical, social/behavioral, and clinical science.

PI_NAMEs: GANDHI, MONICA ;JOHNSON, MALLORY O (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Affect;AIDS clinical trial group;Applications Grants;Applied Research;Area;Behavioral;Behavioral Sciences;California;career;career development;Clinical;Clinical Sciences;cohort;Cohort Studies;Communities;Data;Data Analyses;Development;Development Plans;Education;education research;Elements;Environment;Epidemic;ethnic minority;experience;Fostering;Foundations;Funding;gender minority;Geography;Grant;Health;health inequalities;HIV;HIV disparities;HIV Vaccine Trials Network;HIV/AIDS;human capital;improved;Individual;innovation;Institution;Knowledge;Lead;Manuscripts;marginalized community;marginalized population;Medicine;Mentors;Mission;multidisciplinary;National Institute of Allergy and Infectious Disease;next generation;peer;peer networks;Peer Review;Population;Positioning Attribute;Prevention;Prevention Research;Process;professor;Program Development;programs;racial minority;Recording of previous events;Research;Research Infrastructure;Research Personnel;Research Proposals;residence;response;San Francisco;Scholars Program;Science;Scientist;Secure;sexual minority;skill acquisition;skills;social;social capital;Social Sciences;Strategic Planning;Structure;support network;Training;Training and Infrastructure;Underrepresented Minority;United States National Institutes of Health;Universities;webinar;Writing

PROJECT_TITLE: The HIV Nexus Scholars Program: A Research Education Program for Early-Stage Investigators Working at the Intersection of Biomedical, Social/Behavioral, and Clinical Science


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Clinical Research;Genetics;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative Mitochondria play a crucial role in metabolism, and lysosomes, another compartment in cells, play a role in cellular waste removal and metabolic homeostasis. We discovered that mutations in a mitochondrial gene that result in human neurological diseases cause not only mitochondrial problems, but also lysosomal dysfunction. Our project will study how mitochondria communicate with lysosomes to achieve balanced metabolism for healthy neurons.

PI_NAMEs: YOON, WAN HEE  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;Affinity;Binding;Biogenesis;Brain;brain malformation;brain size;Cells;Communication;Complex;Defect;Development;Disease;disease model;Docking;dominant genetic mutation;Dominant-Negative Mutation;Drosophila genus;early onset;Embryo;Excision;Exhibits;experimental study;Family;fly;FRAP1 gene;Functional disorder;gene correction;Gene Expression;Genes;Goals;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Health;Homeostasis;Human;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insight;Lead;loss of function mutation;lysosomal proteins;Lysosomes;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial membrane;Mitochondrial Membrane Protein;Modeling;Molecular;Morphology;mutant;Mutation;Nervous System Disorder;neurogenesis;Neurologic;neuron development;Neurons;novel;Nuclear;null mutation;nutrition;Optic Atrophy;Organoids;overexpression;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;Peripheral;Peripheral Nervous System Diseases;Play;Positioning Attribute;protein expression;Proteins;rare variant;reduce symptoms;Regulation;Role;Signal Transduction;Syndrome;Testing;therapeutic target;transcription factor;wasting;Work

PROJECT_TITLE: Role of ATAD3A in Lysosomal Homeostasis and Neurogenesis

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Men with low levels of testosterone have substantially elevated risk of atherosclerosis, the leading cause of heart disease and stroke in the United States. Increasing evidence suggests that in addition to peripheral mechanisms, the brain also has the capacity to regulate risk factors of atherosclerosis. The proposed study aims to investigate hypothalamic gliosis as a pivotal mechanism through which testosterone deficiency promotes atherosclerosis.

PI_NAMEs: DORFMAN, MAURICIO D (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Ablation;Acceleration;Androgen Receptor;Androgens;Animal Model;Astrocytes;Atherosclerosis;atherosclerosis risk;Attenuated;Autopsy;Biochemical;Biology;blood glucose regulation;Body Composition;Brain;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career development;Castration;Cause of Death;Cells;Chile;Chronic;Consumption;Data;deprivation;designer receptors exclusively activated by designer drugs;Development;dietary;Disease Progression;Doctor of Philosophy;Dyslipidemias;education research;Educational Activities;Endocrinology;energy balance;Event;excessive weight gain;experimental study;Fatty Liver;feeding;Fellowship;Genetic;glial activation;Gliosis;Glucose Intolerance;Goals;Gonadal Steroid Hormones;Heart Diseases;High Fat Diet;high risk;Histopathology;hormone therapy;Human;Hyperlipidemia;Hyperphagia;Hypogonadism;Hypothalamic structure;in vivo;Incidence;Inflammation;Inflammatory;International;Intervention;Investigation;Leukocytosis;Link;Lipids;Lipoproteins;Liver;liver inflammation;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Macrophage;Magnetic Resonance Imaging;male;Mediator;Medicine;men;Mentors;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;Methods;Microglia;Modeling;Monocytosis;mouse model;multidisciplinary;Mus;mutant;Neuroglia;NF-kappa B;novel;nutrition;Obesity;Operative Surgical Procedures;overexpression;Pathway interactions;Peripheral;pharmacologic;Pharmacology;Plasma;Play;Postdoctoral Fellow;Predisposition;Prevention;Prevention strategy;professor;Program Development;Property;Proprotein Convertases;Qualifying;Regulation;Research;Research Assistant;Research Personnel;Resources;response;Risk;Risk Factors;Role;Serum;Signal Transduction;skills;Stroke;Subtilisins;System;systemic inflammatory response;Technology;Testing;Testosterone;testosterone replacement therapy;tool;Training;Triglycerides;United States;Universities;Very low density lipoprotein;Washington;Weight Gain;western diet;Work

PROJECT_TITLE: Central regulation of atherosclerosis by testosterone-deficiency


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: Chicago

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: NARRATIVE  This research application is relevant to the public health because it proposes to investigate new combination therapies for the treatment of Krabbe disease. Our work, while focusing on a single lipidosis has immediate and vertical impact on other lysosomal storage diseases. Therefore, this proposal is relevant to the overall NIH’s mission of furthering knowledge that will contribute to reduce neurological burden, is framed within the Brain initiative and fits the goals of NINDS and NICHD.

PI_NAMEs: BONGARZONE, ERNESTO ROQUE (contact)

PROJECT_TERMS: Address;adeno-associated viral vector;Adolescent;Adult;Affect;Aftercare;Age;Age Months;Age of Onset;aged;Animal Disease Models;Birth;Brain;BRAIN initiative;canine model;Cells;Ceramides;Child;Clinical;Clinical Trials;Cognitive deficits;Collaborations;Combined Modality Therapy;Complement;Cycloserine;Data;deacylation;Development;Disease;efficacy evaluation;efficacy testing;Engraftment;Enzymes;galactosylceramidase;Galactosylceramides;galactosylgalactosylglucosylceramidase;Galactosyltransferases;gene therapy;gene therapy clinical trial;Gene therapy trial;Gliosis;Globoid cell leukodystrophy;Goals;Hematopoietic Stem Cell Transplantation;Heterozygote;Human;improved;Infant;Infantile Globoid Cell Leukodystrophy;inhibitor;inhibitor therapy;irradiation;Knowledge;leukodystrophy;Life;Life Expectancy;life span;Lipoidosis;Lysosomal Storage Diseases;Measurable;Mediating;Mission;Modeling;Morbidity - disease rate;mortality;motor deficit;mouse model;Mus;Mutation;Myelin;National Institute of Child Health and Human Development;National Institute of Neurological Disorders and Stroke;Neonatal;Nervous System;Nervous System Disorder;neuroinflammation;Neurologic;Neurons;neuropathology;new combination therapies;novel therapeutics;Outcome;Pathogenicity;Pathology;Pathway interactions;Patients;Pharmacologic Substance;Phenotype;postnatal;postnatal development;pre-clinical;preconditioning;prevent;Prevention;Production;Psychosine;Public Health;Quality of life;Recurrent disease;Research;Risk;Risk Reduction;Safety;Serine;side effect;Sphingosine;standard of care;success;synergism;Testing;Time;Transferase;transplant model;Transplantation;Treatment Efficacy;United States National Institutes of Health;Viral;Viral Genes;Viral Vector;Work

PROJECT_TITLE: CGT and ACD Inhibitors for SRT Treatment of Krabbe Disease

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE Many behavioral and mental health disorders manifest as changes in patterns of neural activity. Utilizing these changes in brain activity to improve treatment is complicated by the fact that there are many individual differences in brain activity in healthy individuals. By providing fundamental insight into the neural and molecular basis of individual differences in brain function, our findings will positively impact our ability to treat disorders localized to the brain.

PI_NAMEs: KENNEY, JUSTIN WARD (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Adult;Animal Model;Behavior;Behavioral;behavioral health;Biology;Brain;Brain region;Characteristics;Development;Disease;Exploratory Behavior;Genes;Genetic;genetic manipulation;Goals;improved;Individual;Individual Differences;insight;long term memory;Mammals;Measures;memory recall;Mental disorders;Molecular;Morphology;Nervous System;neural;neural patterning;Neurosciences;Neurotransmitters;New Territories;Pattern;personalized approach;public health relevance;receptor;Research;sex;Structure-Activity Relationship;Vertebrates;Zebrafish

PROJECT_TITLE: Neural and Molecular Basis of Individual Differences in Brain Function and Behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome;Nutrition

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Relevance Recent work has demonstrated that a healthy intestinal microbiota protects against intestinal infection, while a dysbiotic microbiota may accelerate malnutrition and the development of chronic metabolic diseases such as obesity and diabetes. This work seeks to harness the power of the model organism Drosophila with its extensive and accessible genetic tools to dissect the pathways through which microbes communicate with the host intestine, to establish the bacterial signals that contribute to activation of a robust intestinal innate immune response, and to understand how the diverse cell types in the intestine coordinate their response to intestinal invasion. These studies may identify host proteins and signaling pathways that can be targeted with prebiotics, probiotics, or small molecules to promote metabolic homeostasis and a protective response to intestinal infection.

PI_NAMEs: WATNICK, PAULA I (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Acceleration;Acetates;Acetylation;Androgen Receptor;anti-microbial peptide;Arthropods;Bacteria;cell type;Cells;Chromatin Modeling;chromatin remodeling;Chromatin Remodeling Factor;Chronic;chronic infection;Circadian Rhythms;colonization resistance;commensal bacteria;commensal microbes;Communication;Communities;Conserved Sequence;cytokine;Data;Dependence;design;Development;Diabetes Mellitus;Disease;Drosophila genus;Drosophila melanogaster;dysbiosis;ecdysone receptor;enteric infection;enteric pathogen;Enterocytes;Enteroendocrine Cell;Epithelium;experimental study;Fermentation;fly;Genetic;Genetic Transcription;Goals;gut microbes;gut microbiota;Health Promotion;histone acetyltransferase;Histones;Home;Homeostasis;Homologous Gene;Immune;Immune response;Immune signaling;immunodeficiency;Infection;Ingestion;innate immune function;Innate Immune Response;Innate Immune System;insulin signaling;intestinal epithelium;Intestines;Invaded;Laboratories;Learning;Link;lipid metabolism;Lipids;Malnutrition;Mammals;Mediating;Metabolic;Metabolic Diseases;Microbe;microbial;microbial community;microbiota;model organism;Modeling;Modernization;Names;Natural Immunity;novel;Nuclear;Nutrient;Obesity;Oral;pathogen;pathogenic bacteria;Pathway interactions;Peptide Synthesis;Peptides;Peptidoglycan;prebiotics;Predisposition;prevent;Probiotics;Protein Acetylation;Proteins;Proteomics;receptor;Regulatory Pathway;Research;Resistance to infection;response;Role;Satiation;Seminal;Signal Pathway;Signal Transduction;small molecule;stem;stem cells;Testing;therapy development;Time;TNF gene;tool;Transcriptional Activation;Transcriptional Regulation;Transgenic Organisms;uptake;Variant;Vibrio cholerae;Vibrio cholerae infection;wasting;Work

PROJECT_TITLE: Control of intestinal innate immunity by the commensal microbiota in a model host

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Lung;Prevention;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative The wide use of hazardous chemical (including acrolein and phosgene) requires the development of counter measures for accidental or intentional (e.g., terrorism) exposures. Exposure to these chemicals can produce delayed pulmonary edema which is often fatal and to better understand the molecular mechanisms of chemical- induced acute lung injury, mice will be exposed to acrolein, or phosgene and detailed molecular analyses will be performed. The outcome of this research could have sustained public health impact and inform the ongoing investigations into this illness as well as diagnosis, treatment, and prevention.

PI_NAMEs: LEIKAUF, GEORGE DOUGLAS (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: 129X1/SvJ Mouse;Accidents;Acrolein;Acute Lung Injury;Acute Respiratory Distress Syndrome;Age;Air;Alveolar;alveolar epithelium;Bronchoalveolar Lavage;Carbon;Cell Death;Cells;Cessation of life;Chemical Weapons;Chemicals;Complex;Critical Pathways;Death Rate;design;Development;Diagnosis;Disease Progression;Endothelium;Etiology;Event;Experimental Models;Exposure to;Eye;Female;Freezing;Gases;Genetic Predisposition to Disease;Global Warming;Goals;Hazardous Chemicals;Histopathology;Infiltration;Inhalation;Injury;innovation;insight;Investigation;Irritants;irritation;Knowledge;lipidomics;Lipids;Lung;lung injury;macromolecule;male;Measures;Mechanical ventilation;metabolomics;Methods;Molecular;Molecular Analysis;Molecular Target;mortality;Mouse Strains;multiple omics;Mus;Neutrophil Infiltration;Outcomes Research;Oxygen;Partial Pressure;Pathologic;Pathway interactions;Patients;Phosgene;Predisposition;Prevention;Proteins;Public Health;Pulmonary Edema;Reaction;Research;research clinical testing;Resistance;Resolution;Respiratory System;response;Risk Factors;Severities;sex;single-cell RNA sequencing;skin burn;SM/J Mouse;Smoke;smoke inhalation;Structure;Terrorism;Testing;Therapeutic Intervention;therapeutically effective;therapy development;Time;Transcript;transcriptomics;Wildfire;World War I

PROJECT_TITLE: Pathophysiological Mechanisms of Chemical-Induced Acute Lung Injury


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Heart attacks (myocardial infarction, (MI)) predispose to ventricular arrhythmias (VAs) and sudden cardiac death (SCD). Alterations within cardiac sympathetic nerves after MI are tightly linked to VAs, however, the mechanisms by which this occurs are not understood. Here, we will test the hypothesis that chronic cardiac afferent signaling primarily causes sympathetic neural remodeling and dysfunction that lead to VAs.

PI_NAMEs: AJIJOLA, OLUJIMI A (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acute;afferent nerve;Agonist;Animals;Anti-Arrhythmia Agents;Attenuated;Axon;beta-adrenergic receptor;Biological Availability;Calcium Channel;Cardiac;Cause of Death;Chronic;Cicatrix;Clinical;Clinical Management;clinical translation;comparative efficacy;Data;Detection;Development;Drug usage;Electrophysiology (science);Epicardium;excitotoxicity;Family suidae;Feedback;Fiber;first-in-human;Functional disorder;glial activation;Goals;Heart;in vivo;Inflammation;injured;Intervention;Ischemia;Link;local drug delivery;Maps;Modeling;multidisciplinary;Myocardial;Myocardial dysfunction;Myocardial Infarction;Myocardium;Nature;Nerve;Nerve Fibers;neural;neurochemistry;neuroinflammation;Neurons;neuropeptide Y;neuroregulation;neurotransmission;neurotransmitter release;Norepinephrine;novel;novel therapeutics;Oral;Pathologic;Patient Care;Patients;Pattern;Pharmaceutical Preparations;Phase;Pilot Projects;Play;prevent;release factor;Research Personnel;Resiniferatoxin;Risk;Role;Shapes;side effect;Signal Transduction;Site;Spinal;Spinal Cord;Structure;Structure of stellate ganglion;sudden cardiac death;Sympathetic Nervous System;Testing;Time;tool;Translating;TRPV1 gene;Ventricular Arrhythmia;Ventricular Tachycardia

PROJECT_TITLE: Mechanisms of Cardiac TRPV1 Afferent Remodeling in Ventricular Arrhythmias

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Prevention

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The objective of our Clinical Validation Center (CVC) is to advance and validate blood-based detection of colorectal advanced adenoma. Blood-based testing, to be maximally effective for colorectal cancer, should have sufficient sensitivity not only for cancer, but also for premalignant lesions, especially advanced adenomas, which are more likely to evolve into cancer. We will collect high quality blood specimens from a large number of subjects with advanced adenoma prior to undergoing polypectomy and serially post- polypectomy as well as from relevant control subjects to evaluate biomarkers for detection of advanced adenoma and for recurrence risk assessment.

PI_NAMEs: SCHOEN, ROBERT E. (contact);TOMASETTI, CRISTIAN

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: adenoma;Adenomatous Polyps;Aneuploidy;Biological Assay;Biological Markers;biomarker validation;Blood;Blood specimen;Blood Tests;blood-based biomarker;Cancer Detection;Cancer Etiology;cancer invasiveness;cancer prevention;Case/Control Studies;Cell Proliferation;Cessation of life;Clinical;clinical center;Clinical Skills;Collaborations;Collection;Colonoscopy;Colorectal;Colorectal Cancer;colorectal cancer screening;Complement;Custom;Data;Detection;detection method;DNA;DNA Fragmentation;Early Detection Research Network;Early Diagnosis;Encapsulated;Evaluation;Evolution;Excision;Feces;follow-up;frontier;Genes;Goals;Incidence;Industry;innovation;innovative technologies;interest;Laboratories;Lesion;machine learning algorithm;Malignant Neoplasms;Methods;methylation biomarker;Minority Groups;Molecular;molecular marker;Monitor;mortality;Mutation;novel;Outcome;Patient Recruitments;Patients;Pattern;Performance;Phase;Polypectomy;Polyps;Population;premalignant;prevent;Process;prospective;Proteins;Protocols documentation;Public Health;randomized trial;Recurrence;Recurrent disease;Reproducibility;Risk;Risk Assessment;Sampling;screening;Sensitivity and Specificity;Signal Transduction;Site;Specimen;success;Techniques;Technology;Testing;tumor DNA;United States;Universities;uptake;Validation;validation studies

PROJECT_TITLE: Blood-Based Testing for Advanced Adenoma


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Sleep Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Obstructive sleep apnea is a common condition with serious consequences, but current treatments are often not well tolerated, thus many patients remain untreated. The PI and his mentor/advisor-team believe that studying mechanisms underlying sleep apnea can help to develop pharmacotherapy as an alternative treatment option for these patients. This proposal will lay the groundwork for the PI to become an independent investigator focused on translating findings from physiology studies into the clinic, ultimately to improve and personalize the care of people with sleep apnea.

PI_NAMEs: SCHMICKL, CHRISTOPHER NIKOLAUS (contact)

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: Acetazolamide;Address;Adult;Affect;alternative treatment;Apnea;Arousal;awake;Award;Biometry;Blood Pressure;blood pressure reduction;Body mass index;Carbonic Anhydrase Inhibitors;career development;Clinic;Clinical;Clinical Trials;Cognition;Continuous Positive Airway Pressure;cost;Cross-Over Trials;Data;design;Development;Development Plans;Diuretics;Doctor of Philosophy;Dose;Drowsiness;drug development;Enrollment;Epidemiology;experience;Functional disorder;functional outcomes;Goals;hands on research;hangover;Health;Hypertension;Hypoxemia;Hypoxia;Impaired cognition;Impairment;improved;indexing;Individual;individual patient;insight;instrument;Intervention;Long-Term Effects;Longitudinal Studies;Measures;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mission;Myocardial Infarction;National Heart, Lung, and Blood Institute;Neurocognitive;novel;Obstructive Sleep Apnea;Outcome;Oxygen;Pathogenesis;Patient Care;Patient Outcomes Assessments;Patient Selection;Patients;personalized care;personalized intervention;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physicians;Physiological;Physiology;Placebo Control;Placebos;Positioning Attribute;Publishing;Quality of life;Questionnaires;Randomized;Research;Research Infrastructure;Research Personnel;response;responsible research conduct;Risk;Scientist;sedative;Severities;skills;Sleep;Sleep Apnea Syndromes;Sleep disturbances;Sleep Fragmentations;sleep quality;standard of care;Stimulant;Stroke;Subgroup;Testing;Time;Training;Translating;United States National Institutes of Health;vehicular accident;vigilance;Vision;Work

PROJECT_TITLE: Acetazolamide to Improve Clinically Important Outcomes in Obstructive Sleep Apnea Patients with a High Loop Gain Endotype


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE Single-cell genomics are helping to reshape our understanding of human development and identify pathogenic cell types in a variety of settings. The work proposed in this application will improve single-cell technologies so that they can more accurately measure time. This will potentially have widespread implications for public health, including leading to improved stem cell treatments, better understanding of intervention time windows, and more targeted gene therapies.

PI_NAMEs: CUSANOVICH, DARREN A (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Adult;Biological Assay;Cell Differentiation process;cell type;Cells;Cues;Development;Developmental Biology;Developmental Process;Disease;Disease Progression;DNA Sequence;Event;Gene Expression Profile;gene-targeted therapy;Genome;genomic tools;Genomics;Hepatocyte;Hormonal;Human body;Human Development;Human Genome;improved;Intervention;Leukocytes;Link;Measures;multiplex assay;Pathogenicity;Pathway interactions;Pattern;Process;Public Health;Recording of previous events;Regulation;response;Shapes;single cell genomics;single cell technology;stem cell therapy;Stimulus;success;Technology;Time;tool;Work;zygote

PROJECT_TITLE: Beyond Pseudotime: Enhanced Single-cell Genomics Tools for Understanding the Temporal Dynamics of Development and Disease


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Racial and Ethnic Minority Health Research

ORG_DEPT: OPHTHALMOLOGY

PHR: Narrative Innovations in artificial intelligence (AI) algorithms have exponentially increased with the widespread digitization of healthcare data in general and ophthalmic data in particular. However, the implementation of AI- based technologies into clinical ophthalmic practice for clinical decision support is still in relatively early stages. This study is designed to leverage well characterized clinical and research cohorts of glaucoma patients and its validated decision support AI infrastructure to predict which glaucoma patients will progress and which will need surgery. Specifically, we will develop deep learning algorithms to predict 1) patients who will need glaucoma surgery and 2) patients who are progressing in the next 12 months, and 2 years. We will leverage data from diverse research and clinical glaucoma populations for the development and testing of the deep learning models. These algorithms can then be used to support randomized clinical trial testing of AI guided glaucoma management using the AI models developed.

PI_NAMEs: BAXTER, SALLY LIU;CHRISTOPHER, MARK ;ZANGWILL, LINDA M (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Address;African American population;African ancestry;Age;Algorithms;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;blind;Blindness;California;Caucasians;Clinical;clinical care;clinical decision support;clinical practice;Clinical Research;cloud based;cohort;Communities;comparison intervention;Complement;Cornea;Data;data curation;Data Set;data sharing;deep learning;deep learning algorithm;deep learning model;design;Development;Diagnosis;Diagnostic;Disease;Disease Progression;diverse data;Electronic Health Record;Enrollment;Evaluation Studies;Eye;Family;follow-up;Funding;Future;Glaucoma;glaucoma surgery;Healthcare;high risk;Hispanic;Image;improved;Individual;individualized medicine;Infrastructure;innovation;Knowledge;Latino Population;Minority;Minority Groups;model development;Modeling;Monitor;multimodality;National Eye Institute;Operative Surgical Procedures;Ophthalmology;Optic Disk;Optical Coherence Tomography;Outcome;patient engagement;Patients;personalized management;Physiologic Intraocular Pressure;Population;precision medicine;randomized, clinical trials;Research;research study;Retina;Risk;Science;Secure;Technology;Testing;Thick;Time;Training;Universities;Update;Vision research;Visual Fields

PROJECT_TITLE: Multimodal Artificial Intelligence to Predict Glaucomatous Progression and Surgical Intervention


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Urologic Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE In patients with urinary stone disease, several knowledge gaps persist regarding the impact of fluid therapy in preventing stone recurrence, and the optimal care after insertion of a ureteral stent (a thin tube inserted into the ureter to prevent obstruction of the urine flow from the kidney). This application will address these gaps by assessing the effectiveness and safety of new behavioral strategies to increase urine fluid intake, and evaluating factors contributing to discomfort following stent insertion, with the ultimate goal of improving patient care.

PI_NAMEs: REESE, PETER PHILIP;TASIAN, GREGORY EDWARD (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Address;Adherence;adjudication;Adolescent;Adult;arm;associated symptom;Behavior;Behavior Therapy;Behavioral;Biological;Blood;Caring;Child;Childhood;Clinic;Clinical;clinical care;clinical center;Clinical Research;cohort;Collection;Communities;cost;COVID-19;COVID-19 pandemic;Data;Data Collection;Deposition;design;Development;Disease;Effectiveness;effectiveness evaluation;Endocrinologist;Enrollment;Ensure;evaluation/testing;Event;Excision;experience;financial incentive;Fluid Therapy;follow-up;Foundations;Future;Goals;Health;health care service utilization;Health system;Hospitals;Hydration status;improved;Individual;innovation;insight;Institution;Intake;Intervention;Interview;Investigation;Kidney;Kidney Calculi;Knowledge;Lifting;Liquid substance;Lived experience;Manuscripts;Measures;Medical;Medicine;Morbidity - disease rate;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;novel;observational cohort study;Obstruction;Operative Surgical Procedures;Outcome;Output;Pain;Participant;participant enrollment;Patient Care;Patient Recruitments;Patients;Pediatric Hospitals;Peer Review;Pennsylvania;Perioperative complication;Philadelphia;Plasma;Prevalence;prevent;Prevention;primary endpoint;Problem Solving;Procedures;programs;prospective;Prospective, cohort study;Psychosocial Assessment and Care;Public Health;Publications;Questionnaires;radiologist;Randomized;randomized, clinical trials;Recommendation;recruit;Recurrence;Recurrent disease;Regimen;Reporting;repository;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;Resources;response;Safety;Sampling;Science;Scientist;Sensory;Serum;Site;Societies;Specific qualifier value;Stents;Structure;success;Symptoms;Texas;therapy design;Thinness;Time;Touch sensation;treatment arm;Tube;Universities;Ureter;Ureteroscopy;urinary;Urinary Calculi;Urine;urologic;Urologist;Visit;Washington;Water;Whole Blood

PROJECT_TITLE: Harnessing Behavior to Decrease Urinary Stone Disease Morbidity Research Project


ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: NARRATIVE Neutrophils are blood cells that protect the body from infections, but their unregulated activation leads to disease in humans. Cardiovascular disease remains a leading cause of death worldwide but how neutrophils and their precursors contribute to the development and progression of cardiovascular disease is currently unknown. The objective of this Program is to elucidate the mechanisms regulating neutrophil-mediated inflammation in coronary artery disease and to discover new therapies to treat this devastating and common disease.

PI_NAMEs: CATZ, SERGIO DANIEL (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: adaptive immune response;Address;Adult;Aorta;Apoptosis;Area;Arterial Fatty Streak;atherogenesis;Atherosclerosis;atherosclerotic plaque rupture;Attenuated;Automobile Driving;Biology;Bone Marrow;Cardiovascular Diseases;Cause of Death;Cell Lineage;Cell Physiology;Cells;Cellular biology;Cessation of life;Chronic;Circulation;Complex;Coronary Arteriosclerosis;Cues;Cytoplasmic Granules;Cytoprotection;Data;design;Development;Disease;Disease Progression;Endothelium;Evaluation;Exocytosis;extracellular;Genetic;Goals;Granulopoiesis;Heart Diseases;Hematological Disease;Hematopoietic stem cells;Heterogeneity;Human;human subject;Hyperlipidemia;Immunology;Infection;Inflammasome;Inflammation;Inflammatory;Innate Immune Response;interdisciplinary approach;Interleukin-1 beta;Invaded;Laboratory Research;Lesion;life span;Mammals;Mediating;Mediator;microorganism;Mission;Mitochondria;Modeling;Molecular;Mus;Myocardial Infarction;National Heart, Lung, and Blood Institute;neutrophil;Neutrophil Activation;novel strategies;novel therapeutics;Pathogenesis;Pathogenicity;Pathologic;Pathology;Plasma;pre-clinical;Prevention;Process;Production;progenitor;programs;Proteins;Receptor Signaling;Regulation;Research Personnel;Research Project Grants;response;Role;Rupture;secretory protein;Signal Transduction;Technology;Testing;Tissues;trafficking;translational approach;Validation

PROJECT_TITLE: Neutrophil lineage in inflammation


PROJECT_TERMS: Administrator;Biometry;Budgets;Communication;data sharing;Data Storage and Retrieval;Doctor of Philosophy;Ensure;Grant;Home;Inflammation;Information Technology;Institution;Lead;Maintenance;Manuscripts;meetings;neutrophil;organizational structure;Preparation;Principal Investigator;Program Research Project Grants;programs;Research;Research Institute;Resources;Secure;Site;success;symposium;Travel

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebral Palsy;Clinical Research;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rehabilitation

ORG_CITY: MADISON

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Public Health Relevance Statement There is a critical need for reliable quantitative brain imaging techniques for clinical and research studies of young healthy children as well as pediatric patients with neurological, genetic, and developmental disorders. This project will develop and optimize novel MRI (magnetic resonance imaging) methods for quantitative brain imaging studies of infants and toddlers during natural sleep, which will improve the success rates of the imaging methods in younger and more intellectually disabled children without sedation. These techniques are targeted towards accurate quantitative relaxometry, reducing imaging times, correcting the effects of head motion, and reducing acoustic noise. Standardized brain templates of infants and toddlers will be developed for comparison in future studies. These technologies will be evaluated in infants at risk for cerebral palsy.

PI_NAMEs: ALEXANDER, ANDREW L (contact);GILLICK, BERNADETTE THERESE;KECSKEMETI, STEVEN R

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 2 year old;3-Dimensional;Acoustics;Address;Adult;Affect;Age;Age Months;age related;Area;Attenuated;Axon;Basal Ganglia;Brain;brain abnormalities;Brain imaging;Brain Injuries;Brain region;brain tissue;Cerebral Palsy;Child;Child Development;Childhood;Clinical;clinical diagnostics;Clinical Research;Clinical/Radiologic;cohort;Cone;Detection;Development;developmental disease;Diagnosis;Disabled Children;Disease;Environment;Evaluation;Future;Genetic;Genetic Diseases;Head;high risk;Image;image reconstruction;imaging modality;imaging study;Imaging Techniques;Imaging technology;Impairment;improved;Individual;Individual Differences;Infant;Infant Development;Intervention;ischemic lesion;Lesion;Life;life span;Loudness;Machine Learning;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;Morphologic artifacts;Motion;Motor;Movement Disorders;multimodality;Myelin;myelination;Nervous System Disorder;neuroimaging;Neurologic;Noise;novel;Outcome;Pathology;pediatric patients;Pediatric Research;Performance;Persons;Population;precision medicine;Predisposition;pressure;prognostic;Prognostic Marker;Property;Protocols documentation;public health relevance;quantitative imaging;Radial;Relaxation;Research;research study;Resources;Risk;Scanning;Sedation procedure;Sensorimotor functions;side effect;Sleep;Software Tools;sound;spinal tract;Standardization;structural imaging;success;Techniques;Technology;Testing;Thalamic structure;Time;Toddler;tool;white matter;white matter damage

PROJECT_TITLE: Motion Robust Relaxometry for Infant Neuroimaging


NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging

PI_NAMEs: KIOSSES, BILL WILLIAM (contact)

PROJECT_TERMS: 3-Dimensional;Actins;Adhesions;analytical tool;Apolipoprotein E;Apoptosis;Apoptotic;Arterial Fatty Streak;Autoimmunity;autoinflammatory diseases;Azurophilic Granule;Bacteria;Biological Assay;Biology;Cardiovascular Diseases;Cell Death;Cell membrane;Cells;Cellular biology;Cessation of life;Collaborations;Coronary Arteriosclerosis;cost;Cytoplasmic Granules;Cytoskeleton;data sharing;Dedications;design;Development;Dimensions;Docking;Electron Microscopy;Ensure;Event;Exocytosis;extracellular;Fibrosis;Fluorescence Microscopy;fungus;Gelatinases;Generations;Goals;High Fat Diet;Human;Hyperlipidemia;Image;in vivo;Inflammasome;Inflammation;Inflammatory;innovation;intravital microscopy;life span;Light;light microscopy;live cell microscopy;Mediating;microscopic imaging;Microscopy;migration;Mitochondria;MMP9 gene;Modeling;Molecular;mouse model;Mouse Strains;Multivesicular Body;Mus;nanometer;neutrophil;Neutrophil Activation;novel strategies;Organelles;Pathway interactions;Patients;Performance;Phagocytosis;Play;Process;Production;Productivity;progenitor;Program Research Project Grants;Proteins;Quality Control;quantitative imaging;Quantitative Microscopy;Reactive Oxygen Species;Research;Resolution;Resources;Role;Sampling;single molecule;Stimulus;superresolution microscopy;Technology;Time;trafficking;ultra high resolution;Vasculitis;Vesicle;Visualization;western diet;Work

PROJECT_TITLE: Neutrophil Microscopy and Quantitative Imaging Core B


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: HEDRICK, CATHERINE C (contact)

PROJECT_TERMS: Acceleration;Acute;acute infection;Age;Antigen-Antibody Complex;Apolipoprotein E;atherogenesis;atheroprotective;Atherosclerosis;Blood;Bone Marrow;Bone Marrow Stem Cell;Cardiovascular Diseases;Cell Death;Cells;Cholesterol;Chronic Disease;Clinical;Clinical Data;Coronary;Coronary Angiography;cytokine;Cytometry;Data;Development;Disease;Elastases;Event;Exocytosis;extracellular;fighting;Frequencies;Generations;Glucose;Granulopoiesis;Heterogeneity;Histone H3;Human;Hyperlipidemia;Immunity;Individual;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Interleukin-1 beta;Interleukin-6;Knockout Mice;Link;Lipids;Lytic;Macrophage;Malignant Neoplasms;Measures;medically necessary care;Molecular;mouse model;Mus;Myocardial;myocardial injury;neutrophil;novel therapeutic intervention;oxidized low density lipoprotein;pathogen;Pathway interactions;Patients;Pattern;peripheral blood;Peroxidases;Phenotype;Plasma;Predisposition;Production;progenitor;Reporting;Role;secretory protein;sensor;Severity of illness;sex;Signal Transduction;stem cells;Testing;Tissues;tumor;Virginia

PROJECT_TITLE: Neutrophil Development During Inflammation and Atherosclerosis


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

PROJECT_TERMS: Actins;Affect;Apolipoprotein E;Atherosclerosis;Autoimmune Diseases;autoinflammatory diseases;Autophagocytosis;Azurophilic Granule;Biology;Bone Marrow;Cardiovascular Diseases;Cell Physiology;Cellular biology;Chronic;Collaborations;Coronary Arteriosclerosis;Cytoplasmic Granules;Defect;Development;Dimensions;Disease;Dyslipidemias;endothelial dysfunction;Exocytosis;exosome;Exposure to;extracellular;Family;Fibrosis;Gene Modified;Genetic;High Fat Diet;Human;Hyperlipidemia;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;inhibitor;Innate Immune Response;Knock-in;marenostrin;Mass Spectrum Analysis;Mediating;Mediator;Methods;Modeling;Molecular;Monomeric GTP-Binding Proteins;Morphology;mouse model;Mus;NADPH Oxidase;nanometer;neutrophil;Neutrophil Activation;novel;Organelles;Pathway interactions;Patients;Physiology;Process;Production;progenitor;Proteomics;rab GTP-Binding Proteins;Reactive Oxygen Species;Regulation;Reperfusion Injury;Research;Role;secretory protein;Sepsis;spatiotemporal;Specificity;superresolution microscopy;systemic inflammatory response;Systemic Inflammatory Response Syndrome;Testing;trafficking;translational approach;translational study;treatment strategy;ultra high resolution;vesicle transport;western diet

PROJECT_TITLE: Neutrophil Mechanisms During Inflammation and Atherosclerosis


PI_NAMEs: HOFFMAN, HAROLD M (contact)

PROJECT_TERMS: Ablation;Acute;Alleles;Animal Model;antagonist;aortic arch;Apoptosis;Apoptotic;Area;Arterial Fatty Streak;Atherosclerosis;automated image analysis;Automobile Driving;BCL2 gene;Cardiac;Cardiovascular Diseases;Cardiovascular system;CASP8 gene;CD95 Antigens;Cell Death;Cell Death Signaling Process;Cell Lineage;Cell Membrane Permeability;Cell Survival;cell type;Cells;Cessation of life;chronic inflammatory disease;Collaborations;Compensation;Coronary Arteriosclerosis;cytokine;Data;Dependence;Disease;Dominant-Negative Mutation;Event;experimental study;extracellular;Family member;Flagellin;gain of function mutation;Generations;Genetic Models;Hemorrhage;Human;Impairment;Induction of Apoptosis;Inflammasome;Inflammation;Inflammatory;Interleukin-1;Interleukins;Kinetics;LDL Cholesterol Lipoproteins;Life;Ligation;live cell imaging;Longevity;loss of function;Lytic;Macrophage;MCL1 gene;Mediating;Mitochondria;mitochondrial membrane;monocyte;Morphology;mouse model;Mus;Myelogenous;Myocardial Infarction;neglect;neutrophil;novel;Outer Mitochondrial Membrane;oxidized low density lipoprotein;Pathogenicity;Pathway interactions;Patients;Pharmacology Study;Production;progenitor;Proteins;receptor;recruit;Regulation;Reporting;Research;response;Role;Rupture;Signal Pathway;Signal Transduction;Stimulus;Stroke;Swelling;Tissues;Tumor Necrosis Factor Receptor;Work

PROJECT_TITLE: Neutrophil Survival and Demise During Inflammatory States


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: PATHOLOGY

PHR: In a racially diverse breast cancer cohort from the South Eastern United States, the levels of the breast cancer biomarker, Kaiso in the cytoplasm, and the nucleus of breast cancer cells are each independent predictors of breast cancer survival based on race. Surprisingly, the cytoplasmic Kaiso levels were also predictive of an immune exhausted or immune-suppressed tumor microenvironment. In this study we propose to validate these observations using 2 different breast cancer cohorts from Africa and across the African diaspora; show how these predictive linkages are influenced by patient features, genetic ancestry and exposures, tumor gene expression, tumor patterns of somatic mutation, and tumor mutational signature; and elucidate the mechanisms linking Kaiso with the breast cancer tumor microenvironment.

PI_NAMEs: GARDNER, KEVIN L. (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: 4T1;access disparities;Admixture;Africa;African;African ancestry;African Caribbean;African Women;aggressive breast cancer;Alcohols;Beds;Behavior;Biological;Breast Adenocarcinoma;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer Risk Factor;breast cancer survival;Breast Feeding;cancer biomarkers;cancer health disparity;cancer subtypes;Cell Line;Cell Nucleus;Cells;cellular engineering;cohort;Collaborations;Country;Cytoplasm;Data;efficacy testing;Engineering;Environmental Exposure;Epidemiologist;Ethnic Origin;Ethnic Population;European ancestry;Evolution;exhaust;exome sequencing;extracellular vesicles;Frequencies;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic signature;Genome;Genomics;Goals;Growth;health care availability;Height;Herbert Irving Comprehensive Cancer Center;Heterogeneity;High Prevalence;high risk;Immune;Immune Evasion;Immune response;Immunofluorescence Immunologic;Immunohistochemistry;improved;Inbred BALB C Mice;Institutional Racism;Invaded;Kenya;Life Style;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Modeling;Molecular;multidisciplinary;multiple omics;Mus;Mutation;Neoadjuvant Therapy;Neoplasm Metastasis;New York;Nigeria;non-genetic;North Carolina;Nuclear;Outcome;outcome disparities;overexpression;pathogen exposure;Pathologist;patient stratification;Patients;Pattern;pharmacologic;Population;population genetic structure;Prediction of Response to Therapy;predictive marker;Predictive Value;Process;prognostic model;prognostic value;Property;protein biomarkers;Race;racial diversity;racial population;Reproductive History;Research Personnel;response;Role;Shapes;socioeconomic disadvantage;Somatic Mutation;survival prediction;The Cancer Genome Atlas;therapy resistant;Tissue Microarray;Tissues;Tobacco;transcriptome sequencing;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Biology;tumor growth;tumor microenvironment;tumor progression;Tumor-Derived;tumor-immune system interactions;United States;Universities;University Hospitals;Variant;Washington;Woman;Xenograft Model

PROJECT_TITLE: The Role of Kaiso as a predictive breast cancer biomarker in Africa and across the African Diaspora

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention;Telehealth;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE Suicidal thoughts, suicide attempts, and suicide are increasingly common in adolescence. Current face-to-face prevention approaches are of limited effectiveness, rely on extensive resources, and are at odds with adolescents’ digital preferences. We will evaluate two unconventional but promising interventions delivered to 13- to 17-year-olds: transcutaneous vagus nerve stimulation to target emotion dysregulation, and a peer-support smartphone app to combat social isolation. If effective, these digitally-delivered interventions could reach far more adolescents at far lower cost than current approaches.

PI_NAMEs: SHEFTALL, ARIELLE HOPE;VALENTINO, KRISTIN  (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: 17 year old;Acceleration;Adaptive Behaviors;Address;Adolescence;Adolescent;Age;Biosensor;Brain;Cause of Death;Cellular Phone;combat;cost;COVID-19 pandemic;Data;Depressed mood;design;Detection;Development;Devices;digital;digital delivery;digital technology;Dose;Ear;Effectiveness;emotion dysregulation;emotion regulation;Emotional;Emotions;Enrollment;Family;Feeling suicidal;follow-up;Fright;Future;Goals;Health Personnel;high reward;high risk;high risk behavior;Hospitalization;improved;innovation;innovative technologies;insight;Intervention;intervention cost;intervention delivery;intervention effect;Investigational Therapies;Investments;Loneliness;maltreatment;Mental Depression;Mental Health;mental training;Monitor;Music;National Institute of Mental Health;negative affect;neighborhood disadvantage;neural;novel;Outcome;Patient Self-Report;peer;peer support;Physiological;Population;positive emotional state;post intervention;preference;Prevention;Prevention approach;Prevention program;preventive intervention;Preventive service;Primary Prevention;Privatization;programs;prospective;Protocols documentation;Public Health;Randomized;Recording of previous events;recruit;Recurrence;reducing suicide;Reporting;Resources;response;Risk;Risk Factors;Rural;satisfaction;scale up;Secondary Prevention;Secure;Self-Injurious Behavior;Sensitivity and Specificity;Services;Signal Transduction;smartphone application;social;Social isolation;Stimulus;Structure;suicidal;suicidal adolescent;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Technology;Telephone;Testing;therapy design;Training;treatment as usual;treatment duration;trend;underserved community;vagus nerve stimulation;Vagus nerve structure;vulnerable adolescent;Youth

PROJECT_TITLE: Leveraging Noninvasive Transcutaneous Vagus Nerve Stimulation and Smartphone Technology to Reduce Suicidal Behaviors and Suicide Among Highly Vulnerable Adolescents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Rare Diseases;Urologic Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Testicular germ cell tumors (TGCT) are the most common tumor type in white men ages 15-45, with an increasing incidence. They have a high heritability and inherited variation underlies ~50% of the risk of the disease. We build upon our prior research in the Testicular Cancer Consortium to identify additional genetic variation associated with disease risk, so that we expand our understanding of TGCT biology and epidemiology, as well as identify the men at highest risk of disease.

PI_NAMEs: KANETSKY, PETER A;NATHANSON, KATHERINE L. (contact)

PROGRAM_OFFICER_NAME: KALIA, SARAH SUJATA

PROJECT_TERMS: Accounting;Address;Adult;Affect;Age;aged;biobank;Biological;Biology;Brothers;cancer type;Candidate Disease Gene;candidate selection;causal variant;Cells;CHEK2 gene;chemotherapy;Chromosome abnormality;Cisplatin;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Common Neoplasm;Copy Number Polymorphism;Data;Data Set;Development;Developmental Cell Biology;Disease;Disease susceptibility;disorder risk;DNA Maintenance;Environmental Risk Factor;Epidemiology;European ancestry;Evaluation;exome;exome sequencing;Fathers;fetal;Genes;genetic association;genetic epidemiology;Genetic Predisposition to Disease;Genetic Variation;genome wide association study;genome-wide;Genomic Instability;Genomics;Genotype;Genotype-Tissue Expression Project;Germ Cells;Goals;Heritability;heterogenous data;high risk;high risk men;improved;in silico;in vitro Model;Incidence;Individual;Infertility;Inherited;insight;International;Investigation;Kinetochores;knock-down;long-term sequelae;Male Infertility;Malignant neoplasm of testis;Malignant Neoplasms;Medicine;member;men;Morbidity - disease rate;Morphology;novel;overexpression;Pathway interactions;Patients;Penetrance;Platinum;Predisposition;Proliferating;rare variant;Research;Resources;Risk;Risk Marker;RNA Splicing;Role;segregation;sex determination;single cell sequencing;Site;Small Interfering RNA;Somatic Cell;Source;Specific qualifier value;Spermatocytes;Statistical Models;success;Survivors;Susceptibility Gene;Testicular Germ Cell Tumor;Time;transcriptome;Tumor Cell Biology;Tumor Cell Line;Validation;Variant;Work;young man

PROJECT_TITLE: Post genome wide association studies in testicular germ cell tumors

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]