NIH_SPENDING_CATS: Cancer

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: 8. Project Narrative This program aims to train a new generation of investigators to understand how behavioral, genetic and environmental factors affect risk of cancer incidence and survival, and to integrate the wealth of new methods in molecular biology (such as genomics and metabolomics), epidemiology, and biostatistics in this effort. Through multidisciplinary training, and leveraging the enormous resources that are available to our students and post- doctoral fellows, we believe that great strides can be made to reduce the burden of cancer in the US and around the world.

PI_NAMEs: ELIASSEN, A. HEATHER  (contact);STAMPFER, MEIR

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: cancer epidemiology;Training Programs

PROJECT_TITLE: Program for Training in Cancer Epidemiology


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Eye Disease and Disorders of Vision;Health Services;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Eye disease screening of the general population is not currently recommended, but few studies have been performed to address screening as a strategy to reduce visual impairment. The proposed research is thus relevant for public health because it will determine the effectiveness of eye disease screening of the general population using optical coherence tomography (OCT), fundus photography, and intraocular pressure (IOP) assessment for detection of glaucoma, diabetic retinopathy, and age-related macular degeneration.

PI_NAMEs: KEENAN, JEREMY DAVID (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Address;Adherence;age group;Age related macular degeneration;Blindness;Caring;Censuses;Cluster randomized trial;Communities;cost;COVID-19;COVID-19 pandemic;Data;Detection;Diabetic Retinopathy;Disease;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation study;Enrollment;Eye;Eye diseases;follow-up;Funding;Fundus photography;General Population;Glaucoma;Goals;Health;Home visitation;Hospital Administration;Hospitals;Impairment;implementation barriers;implementation intervention;improved;Individual;Infrastructure;Institution;Interruption;Intervention;Intuition;Left;Low Prevalence;Measurement;Natural History;Nepal;novel strategies;Older Population;Optical Coherence Tomography;Outcome;Participant;Patients;Persons;Physiologic Intraocular Pressure;Policy Maker;population based;Population Study;post-COVID-19;prevent;Prevention;Prevention program;primary outcome;programs;Progressive Disease;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Resource-limited setting;Resources;retinal nerve fiber layer;Running;Sample Size;Sampling;screening;secondary outcome;Specific qualifier value;success;System;Telemedicine;Testing;Text Messaging;Thick;Time;tonometry;trial design;Visual Acuity;Visual impairment;volunteer;World Health Organization

PROJECT_TITLE: Village-Integrated Eye Worker Trial II (VIEW II) Extension

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (11)]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research

ORG_CITY: ANN ARBOR

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The University of Michigan (UM) PAIN Cohort T90/R90 is ideally suited to train the next generation of post- doctoral pain scientists. The program proposes inter-disciplinary mentoring and training of individuals from disciplines not typically involved in pain research, with a heavy emphasis on training a wide variety of data scientists as well as trainees from our School of Public Health (including biostatistics and epidemiology) and College of Engineering (including computer science and biomedical engineering). By using a vast array of available and willing mentors at UM not formally named on the grant, we will be able to provide each of our Scholars both a junior and senior mentor, as well as an individual with learned experience, as part of their mentoring team.

PI_NAMEs: CLAUW, DANIEL J (contact);KIDWELL, KELLEY MCLAIN;WIENS, JENNA

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: addiction;Anesthesiology;behavioral health;Bioinformatics;Biomedical Engineering;Biometry;Cannabis;career;Chronic;chronic pain;clinical pain;cohort;comorbidity;computer science;design;Discipline;Educational Curriculum;effective intervention;Engineering;Environmental Health;Epidemiologist;Epidemiology;Faculty;Fatigue;Grant;Hallucinogens;health equity;Helping to End Addiction Long-term;life span;Lived experience;Medicine;Mental Health;Mentors;Michigan;Names;next generation;non-opioid analgesic;Nonpharmacologic Therapy;Pain;pain chronification;Pain management;Pain Research;Patients;Persons;Pharmacological Treatment;Physicians;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Prevention;Program Evaluation;programs;Psychologist;Public Health;Research;Research Personnel;Research Training;Scientist;social;Social Sciences;Social Workers;Training;Universities;Work

PROJECT_TITLE: University of Michigan HEAL PAIN Cohort Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-F (90)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BINGHAMTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

ORG_STATE: NY

PHR: Project Narrative: The long-term goal of the SUNY Upstate Bridges to the Baccalaureate Program T34 training grant is to increase the number of under-represented students who transfer from three SUNY community colleges (MCC, OCC, WCC) and complete baccalaureate degrees in disciplines relevant to biomedical and behavioral sciences at Binghamton University. The inclusion of underrepresented groups in the biomedical and behavior science workforce is critical to reducing health disparities and improving the health of all people in the United States.

PI_NAMEs: BABULSKI, JULIE ;DI LORENZO, PATRICIA M;HAMILTON, ELISABETH C;KOSTEL-HUGHES, FAITH ;SAVAGE, LISA M (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Bachelor's Degree;Biomedical Research;bridge program;bridge to the baccalaureate;career;Career Choice;citizen science;Communication;Communities;community college;community engagement;Community Outreach;community partners;Degree Completion;Development;Discipline;Education;Educational workshop;Enrollment;experience;faculty mentor;Fostering;improved;Instruction;interest;International;Laboratories;Laboratory Research;Mathematics;New York;novel;outreach;peer coaching;Performance;programs;Readiness;recruit;Research;Research Ethics;Research Project Grants;Research Training;Rotation;Schools;Science;science education;scientific literacy;skill acquisition;success;summer research;symposium;Training;Training Programs;transfer student;undergraduate student;Underrepresented Students;Universities

PROJECT_TITLE: Bridges to the Baccalaureate Research Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE This Program Project seeks to examine the impact of recent national policies and payment changes on older adults living with Alzheimer's Disease and related dementias (ADRD) in different states of disease progression and in different care settings. Understanding these effects is crucial to document potential unintended consequences and inform policies that enhance access to healthcare, reduce burden on patients and families, improve quality of care, and advance health equity.

PI_NAMEs: THOMAS, KALI ST. MARIE;TRIVEDI, AMAL N. (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;adverse outcome;Advisory Committees;Affect;Aging;Alzheimer's disease related dementia;Area;Award;beneficiary;care delivery;Caregivers;Caring;Case Study;Catalogs;Chronic;Clinical;Cognition;Communities;community based care;Complex;Contracts;cost;COVID-19;COVID-19 pandemic;Data Collection;data infrastructure;data integration;data management;Dementia;design;Disease Management;Disease Progression;end of life care;Enrollment;Ensure;Equity;Ethnic Origin;Exclusion;experience;Exposure to;Family;family burden;federal policy;Grouping;Health;health care availability;health equity;health equity promotion;Health Personnel;Health Policy;Health system;Healthcare;Home;Home Care Services;hospice environment;improved;innovation;insight;Institution;interest;Interest Group;Interview;Knowledge;Lead;Leadership;Lived experience;Low income;Managed Care;Measures;Medicaid;Medicare;Methodology;Methods;Modeling;news;novel;novel strategies;older adult;Outcome;Paper;Patient-Focused Outcomes;Patients;payment;Performance;person centered;Persons;Policies;Policy Maker;Policy Research;Population;Process;Professional Organizations;programs;Provider;public health emergency;Publishing;Qualitative Methods;Quality of Care;Race;Regulation;Reporting;Research;Research Design;Resources;Risk Factors;Services;Shock;Site;Skilled Nursing Facilities;social;sociodemographics;Socioeconomic Status;Special needs plan;stem;Suspensions;System;Testing;treatment and outcome;Update;Vulnerable Populations;web site

PROJECT_TITLE: Alzheimer's Disease and Related Disorders Treatment and Outcomes in America: Changing Policies and Systems.

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (M3)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Comparative Effectiveness Research;Dementia;Health Services;Neurodegenerative;Neurosciences

PI_NAMEs: TRIVEDI, AMAL N. (contact)

PROJECT_TERMS: academic program;Administrative Efficiency;Advisory Committees;Aging;Agreement;Alzheimer's disease related dementia;Annual Reports;Boston;Budgets;care providers;Caregivers;Caring;Clinical Trials;Collaborations;collaboratory;college;Communication;Communities;Complex;Contracts;Data;data platform;data submission;dementia care;design;effectiveness research;Expenditure;Faculty;Family Practice;First Independent Research Support and Transition Awards;Fostering;Foundations;Funding;Geriatric Psychiatry;Geriatrics;Gerontology;Grant;Health Care Research;Health Services Research;Home;Hospitals;human subject;improved;Institution;Institutional Review Boards;interest;Internal Medicine;International;Intervention;Lead;Leadership;Link;Long-Term Care;longitudinal database;Maintenance;Marketing;Medical;medical schools;meetings;Minnesota;Mission;Monitor;National Institute on Aging;Neurology;non-drug;older adult;organizational structure;Pennsylvania;Persons;Policies;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Preparation;Process;Productivity;Program Research Project Grants;programs;Provider;Public Health Schools;Publications;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Role;Schedule;Scientist;Social Sciences;Students;success;System;Training and Infrastructure;Training Programs;treatment and outcome;United States Agency for Healthcare Research and Quality;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Universities;Update;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences

PI_NAMEs: GADBOIS, EMILY AURORA (contact)

PROJECT_TERMS: Address;Advocacy;Affect;Alzheimer's Disease;Alzheimer's disease caregiver;Alzheimer's disease related dementia;Behavior;behavioral impairment;care outcomes;Caregivers;Caring;Case Series;Case Study;Contracts;Country;Data;Data Collection;Disease Progression;end of life outcomes;experience;Family;Feedback;Functional impairment;Goals;Health;health care service utilization;Health Personnel;Healthcare;Healthcare Industry;Healthcare Market;Home;Hospice Care;Impaired cognition;informant;insight;Interview;Lived experience;Marketing;Medicaid;Medicare;meetings;member;Methods;Modeling;Neurodegenerative Disorders;older adult;Outcome;Persons;Policies;Process;Provider;Qualitative Methods;Quality of Care;Recommendation;Research;Research Project Grants;Role;Structure;System;Translating;Translational Research;Translations;treatment and outcome;United States

PROJECT_TITLE: Core B: Primary Data Collection and Partner Engagement


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Health Services;Neurodegenerative;Neurosciences

PI_NAMEs: MEYERS, DAVID JOSEPH (contact)

PROJECT_TERMS: Accounting;Address;Affect;aging population;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;beneficiary;care systems;Caring;Characteristics;Chronic;Chronic Disease;Code;Cognitive;cohort;Communities;Complex;Continuity of Patient Care;Contractor;Contracts;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Files;data management;Data Set;Depressed mood;design;Development;Diagnosis;Disease;Enrollment;Ensure;Future;Generations;Growth;Health;health care service utilization;Heart;Heterogeneity;Home;hospital readmission;Hospitalization;innovation;Journals;Link;Measures;Medicare;Medicare/Medicaid;method development;Methodology;Methods;multiple data sources;novel;Nursing Homes;Outcome;Outcome Measure;pandemic disease;pandemic disruption;Persons;Policies;Policy Maker;Population;Privatization;programs;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Retirement;Services;Shock;Site;Source;Statistical Data Interpretation;statistics;stem;Surveys;System;Testing;Time;tool;treatment and outcome;United States;United States Centers for Medicare and Medicaid Services;Update;Validation;Vertebral column;web site;Work

PROJECT_TITLE: Data Management and Methods Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

PROJECT_TERMS: access disparities;Acute;adverse outcome;Affect;Alzheimer's disease related dementia;beneficiary;Black race;Caregivers;Caring;Clinical;cognitive load;Complex;Continuity of Patient Care;Contracts;Data;design;Drug Prescriptions;dual eligible;Enrollment;Event;experience;Face;federal policy;Formularies;Frequencies;Growth;Health;Health Services;Hispanic;Home;Hospitalization;improved;informant;innovation;Insurance;Insurance Carriers;Interview;Low income;Medicare;Medicare claim;Medicare/Medicaid;Methods;mortality;Neighborhoods;Outcome;payment;Performance;Persons;Pharmaceutical Preparations;Physicians;Policies;Population;Privatization;programs;Quasi-experiment;Randomized;Risk;Services;social;social disparities;Special needs plan;Structure;System;Time;treatment and outcome;Uninsured Medical Expense;United States Centers for Medicare and Medicaid Services;Work

PROJECT_TITLE: Effects of Contract Terminations for Medicare Advantage Enrollees with Alzheimer's Disease and Related Dementias


PI_NAMEs: THOMAS, KALI ST. MARIE (contact)

PROJECT_TERMS: Academy;Affect;Alzheimer's disease related dementia;Assisted Living Facilities;Beds;beneficiary;care costs;care systems;Caring;Communication;Communities;community living;community organizations;Complex;copayment;COVID-19 pandemic;Data;Dementia;Diagnosis;dual eligible;Dual Enrollment;Eligibility Determination;Emergency Situation;Enrollment;Ensure;Evaluation;federal policy;Financial Hardship;Financial Support;Fright;Goals;Health;Health Services Accessibility;Healthcare;Home;Hospitalization;Improve Access;improved;Insurance;Interview;Knowledge;Learning;Long-Term Care;Low income;Medicaid;Medicaid eligibility;Medical;Medicare;Medicine;Methods;Names;novel;Nursing Homes;older adult;Organizational Decision Making;Outcome;pandemic disease;patient home care;Persons;Policies;Policy Maker;poor health outcome;Population;Process;programs;Provider;Qualifying;Quality of life;Quasi-experiment;Research;Research Design;Research Priority;Research Technics;Risk;Role;Self Care;Services;Source;stressor;System;Testing;treatment and outcome;trend;Uninsured Medical Expense;Variant;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Impact of Medicaid Continuous Coverage for Older Adults with Alzheimer's Disease and Related Dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BELANGER, EMMANUELLE  (contact)

PROJECT_TERMS: Alzheimer's disease related dementia;Area;Assisted Living Facilities;beneficiary;Black race;care costs;care delivery;care outcomes;caregiving;Caring;Characteristics;cohort;cost;Cost Savings;County;curative treatments;Data;Dementia;design;Diagnosis;Eligibility Determination;end of life;end of life care;Enrollment;ethnic disparity;ethnic minority population;Ethnic Population;evidence base;experience;financial incentive;flexibility;Goals;Healthcare;Heterogeneity;Hispanic;Hospice Care;hospice environment;hospice utilization;hospitalization rates;improved;Incentives;informant;innovation;Inpatients;Insurance;Marketing;Medicare;member;model design;Modeling;Not Hispanic or Latino;Nursing Homes;Outcome;Palliative Care;Penetration;Persons;Policies;Population;Prognosis;programs;Provider;Quality Indicator;Quality of life;racial disparity;racial minority population;racial population;Research;Research Design;Research Methodology;Risk;Sampling;Services;social;System;Terminal Disease;Testing;treatment and outcome;United States Centers for Medicare and Medicaid Services;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Impact of the Medicare Advantage Hospice Carve-In on End-of-life Care Outcomes among Beneficiaries with Alzheimer's Disease and Related Dementia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PI_NAMEs: RAHMAN, MD MOMOTAZUR (contact)

PROJECT_TERMS: access disparities;acute care;Admission activity;Advocacy;Affect;aging in place;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;Assisted Living Facilities;base;beneficiary;care episode;care outcomes;Caregivers;Caring;Certification;Characteristics;cognitive function;Communities;community living;cost;Data;Data Set;Dementia;design;Diagnosis;Disparity;Environment;ethnic minority;Ethnic Origin;Evaluation;experience;functional decline;functional improvement;Geographic Locations;Grouping;Health;health care availability;health care delivery;health care service;health care service utilization;Health Personnel;Health Services;Health Services Accessibility;Healthcare;Healthcare Market;Heterogeneity;Home;Home Care Services;Home Health Agency;Home Ranges;Hospitalization;Impaired cognition;improved;improved outcome;Incentives;Individual;Industry;informant;insight;Interview;Knowledge;Light;Long-Term Care;Medicare;Medicare claim;Methods;mild cognitive impairment;Modeling;Modification;mortality;multiple data sources;Nursing Homes;Outcome;outcome disparities;Patient-Focused Outcomes;Patients;Pattern;payment;Persons;Play;Policies;Policy Maker;Population;Provider;Quality of Care;Race;racial minority;Research;Role;rural setting;Services;skills;stakeholder perspectives;Structure;Symptoms;System;Time;treatment and outcome;uptake;Variant

PROJECT_TITLE: Implications of the Patient-Driven Grouping Model on Home Health Care Utilization and Outcomes for Persons with Alzheimer's and Related Dementias


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: The relevance of immunology research to advances in public health has never before been so strong. This pre- and post-doctoral training program is committed to inculcating detailed understanding of the immune system as well as broad knowledge of molecular and cell biology and the principles of rigorous, elegant experimentation, in a manner that fosters innovative and inspirational contributions by the next generation of immuno-biologists.

PI_NAMEs: BARTON, GREGORY M;ROBEY, ELLEN A (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Immunology & Molecular Medicine Program Training Grant

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ORG_CITY: SAN ANTONIO

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: Project Narrative We propose the MMI-T32 Program at the University of Texas at San Antonio to provide comprehensive evidence-based training and to prepare doctoral students for careers in the Molecular Microbiology and Immunology fields, including in academia and industry. As a minority-serving institution, a major focus of the program is the recruitment and retention of underrepresented students reflecting the changing demographics in the U.S.

PI_NAMEs: CARDONA, ASTRID E (contact);LOPEZ-RIBOT, JOSE L.;MATHUR, AMBIKA

PROGRAM_OFFICER_NAME: MULACH, BARBARA L

PROJECT_TITLE: MMI-T32 Training Pre-doctoral Scientists in Molecular Microbiology and Immunology at UTSA


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Neurosciences;Pain Research;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE At present there is an enormous need for new safe and efficacious treatments designed to relieve the burden of chronic pain and substance use disorders (SUD). However, there is a deficit of scientists trained to conduct clinical research investigating pain and SUD that can move the fields forward. In order to address this gap, we propose the Promoting Excellence through Pain and Addiction Research Enhancement (PREPARE) Program with the long-term goal of creating the next generation of investigators who will advance science through cutting edge clinical research that helps relieve pain and ameliorate SUD.

PI_NAMEs: GOODIN, BUREL R. (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: addiction;Address;Age;Applied Skills;Area;biopsychosocial;career;career development;chronic pain;chronic pain management;Clinical;Clinical Research;clinical training;cost;design;Development;Development Plans;Disparity;efficacious treatment;Ensure;Ethics;experience;Funding;Goals;high standard;Inequity;Infrastructure;Intervention;Knowledge;medical schools;member;Mentors;multidisciplinary;multimodality;non-opioid analgesic;Opioid;opioid use;Outcome;Pain;Pain management;pain relief;Patients;Persons;post-doctoral training;Postdoctoral Fellow;Productivity;Program Evaluation;programs;Public Health;Recording of previous events;Records;Recovery;recruit;Reporting;Research;research and development;Research Personnel;Resources;responsible research conduct;skills;social;social health determinants;Substance Use Disorder;success;Teacher Professional Development;Training;Training Programs;Translational Research;United States;Universities;Washington;Work

PROJECT_TITLE: PRomoting Excellence through Pain and Addiction Research Enhancement (PREPARE)


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Infectious Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Neutrophils are primary cells of the innate immune response necessary for host defense to infection. We propose to understand the heterogeneity and metabolic regulation of neutrophils using human induced pluripotent stem cells. We will apply genomic and metabolic imaging techniques and zebrafish screening to identify neutrophils with improved antimicrobial function.

PI_NAMEs: HUTTENLOCHER, ANNA  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Anti-Inflammatory Agents;Antiinflammatory Effect;antimicrobial;Antimicrobial Effect;ATAC-seq;Autoimmune Diseases;Bacterial Infections;Bacterial Model;Biological Assay;Biology;Bone Marrow;Cardiovascular Diseases;Cell Differentiation process;Cell Line;Cells;cellular imaging;Data;design;Development;Engineering;Epigenetic Process;Exhibits;GATA1 gene;Generations;Genetic Transcription;Genomics;Goals;Heterogeneity;high reward;Host Defense;Human;Human Biology;human disease;human induced pluripotent stem cells;Imaging Techniques;Immune;Immunity;improved;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;Infection;Inflammation;Innate Immune Response;Innate Immune System;Knock-out;Larva;Leukocytes;life span;Malignant Neoplasms;Metabolic;metabolic imaging;metabolic profile;microbial;migration;Modeling;Motility;multiple omics;Mycoses;neutrophil;Optics;Pathogenesis;Phase;Population;Positioning Attribute;Production;progenitor;Program Development;Property;Regulation;response;screening;Secondary to;single cell analysis;single-cell RNA sequencing;stem cell therapy;Stimulus;System;Testing;Tissues;Training;transcription factor;Transcriptional Regulation;Work;Xenograft Model;Zebrafish

PROJECT_TITLE: Training human iPSC-derived neutrophils for antimicrobial function

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The purpose of this Research Education Training Program, Scholars in Oncology-Associated Research (SOAR), at the University of Chicago Pritzker School of Medicine (PSOM) is to inspire medical students to pursue careers in cancer research through exposure to the full continuum from basic science to translational settings and interdisciplinary collaboration needed to provide patient centered care for the 21st Century. To this end, we designed and implemented a 10-week period of intensive research experiences and related training that are not available through formal NIH training mechanisms. An overarching goal of this renewal application is to build on our success, enhance the program and further provide educational activities that effectively supports training of a physician workforce to meet the nation’s biomedical, behavioral and clinical research enterprise.

PI_NAMEs: OLOPADE, OLUFUNMILAYO F. (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Acceleration;Aging;anti-cancer research;Area;Artificial Intelligence;Attitude;Basic Science;Behavioral Research;Biology;Biomedical Research;Cancer Burden;cancer care;cancer health disparity;Cancer Hospital;Cancer Patient;Cancer Survivor;career;Career Exploration;Caring;Cause of Death;Cessation of life;Chemicals;Chicago;Clinical;Clinical Research;Clinical Sciences;community engaged research;community setting;Comprehensive Cancer Center;Continuity of Patient Care;Country;Coupled;COVID-19;Data Science;design;Diagnosis;disparity reduction;education cost;education research;Educational Activities;effectiveness evaluation;Enrollment;Evaluation;experience;Exposure to;Faculty;Funding;Future;global health;Goals;Grant;Health;health equity;Health Occupations;Hour;implementation science;Income;innovation;Instruction;Intention;interdisciplinary collaboration;interest;Intervention;Investments;Knowledge;Lead;Learning;lectures;Malignant Neoplasms;Medical Education;medical schools;medical specialties;Medical Students;Medicine;men;Mentors;Mentorship;metabolomics;Monitor;Mortality Decline;multidisciplinary;Nature;NCI Center for Cancer Research;novel;Oncology;Outcome;outreach;Participant;patient oriented;Patient-Centered Care;peer;peer coaching;Physicians;Population;Population Heterogeneity;Population Sciences;precision oncology;pressure;Productivity;programs;proteogenomics;Public Health;Publications;PubMed;Reporting;Research;Research Personnel;Research Training;Resources;responsible research conduct;Science;Scientific Advances and Accomplishments;Scientist;Self Efficacy;Series;Site;skill acquisition;skills;Structure;student participation;Students;success;summer program;summer research;Surveys;symposium;Training;Training and Education;Training Programs;Training Support;Travel;tumor;United States;United States National Institutes of Health;Universities;Woman;Work;working group

PROJECT_TITLE: Scholars in Oncology Associated Research (SOAR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (M1)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Neurosciences;Rare Diseases

ORG_CITY: QUEENS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ST. JOHN'S UNIVERSITY

PHR: The removal of a tumor is an important stage of treatment, as it allows the extraction of a large volume of tumor tissue, the reduction of intracranial pressure, the decrease of neurological deficit and the establishment of an exact tumor phenotype to solve the question of further treatment tactics. Modern research has shown that the size of tumor resection is reliably correlated with the life expectancy of patients. In the case of diffuse astrocytomas with a low degree of malignancy, total tumor removal is a key prognostic factor as it effectively reduces the risk of malignant tumor transformation. For adult patients with brainstem high-grade gliomas, one of the rarest and deadliest forms of brain cancer, surgically removing the entire tumor may add many months or potentially years of survival beyond that offered by radiation and chemotherapy. The main paradigm of brain tumor surgery is the maximal removal of the tumor with minimal risk of damage to functionally significant areas of the brain. However, the extraction of a tumor in the white light of a microscope can only achieve a maximum resection in 23–50% of cases. This contributes to maintaining a high interest in the development of intraoperative technologies that allow the differentiation of tumors from surrounding tissues. In this proposed study, we aspire to develop, characterize, and evaluate intranasally delivered tumor-targeting polymeric micelles carrying a self-quenched near-infrared (NIR) imaging agent on its potential in brain imaging and neurosurgical guidance during brain tumor surgery. This system is designed to switch “off” fluorescence signals until the micelles arrive at tumor tissues and begin to release an imaging agent as a monomeric form, resulting in strong fluorescence (“on”) signals on tumor tissues. We believe that the polymeric micelles proposed in this study will offer high sensitivity and specificity in imaging brain tumor for distinguishing tumor tissues from surrounding white matter and ultimately improve surgical outcomes and patient survival, potentially adding decades of quality life.

PI_NAMEs: CHO, HYUNAH  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: absorption;Accidents;Adhesives;Adult;Alginates;Area;Blood - brain barrier anatomy;Brain;Brain imaging;Brain Neoplasms;Brain Stem;brain tissue;brain tumor imaging;Bypass;cancer cell;Cancer Detection;cancer surgery;cancer therapy;Carbocyanines;Carbon;Cell membrane;Cells;Chemotherapy and/or radiation;Chitosan;Clinical;Contrast Media;cyanine dye;Defect;design;Development;Diffuse astrocytoma;Disease;Drops;Dyes;Endothelial Cells;ethylene glycol;Excision;Face;Fluorescence;fluorescence imaging;Formulation;Glioblastoma;Glioma;Goals;Growth;high resolution imaging;Homing;Hydroxypropylcellulose;Image;image guided;Image-Guided Surgery;imaging agent;improved;in vivo;in vivo optical imaging;Individual;Integrins;interest;Intracranial Pressure;Intranasal Administration;intraoperative optical imaging;Iodides;Lesion;Life Expectancy;Light;lipophilicity;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Micelles;Microscope;minimal risk;Modernization;monomer;mouse model;Mus;nano;Near-infrared optical imaging;Neoplasm Metastasis;Neurologic;Neurologic Deficit;neurosurgery;Noise;Normal tissue morphology;Nose;Oncology;Operating Rooms;Operative Surgical Procedures;optical imaging;overexpression;Palpation;Patients;Phenotype;poly(lactic acid);Polymers;Potassium;preservation;Primary Brain Neoplasms;Prognostic Factor;Property;Quality of life;Reporting;Research;Resected;Residual Neoplasm;Risk Reduction;Route;Sensitivity and Specificity;Signal Transduction;Stains;Surgeon;surgery outcome;System;targeted delivery;Techniques;Technology;Testing;Time;Tissues;tumor;Tumor Tissue;Tumor Volume;Visual;Visualization;white matter;Work;xanthan gum;Xenograft procedure

PROJECT_TITLE: Polymeric Micelles for Targeted Delivery of Contrast Agents Through the Nose-to-Brain Route in Image-Guided Brain Cancer Surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-7 (SF)]


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE The prevention of cancer and the delivery of high quality, innovative care to cancer patients are high priorities for researchers, clinicians, and the general public. The overall goal of the CAPACiTy post-doctoral training grant is to provide a comprehensive career development training program for PhD/MD trainees in the skills and competencies needed to conduct rigorous research in cancer control and translational science. Upon completion of training, early stage investigators will be able to lead and collaborate on high impact, cancer control research.

PI_NAMEs: FOLEY, KRISTIE L (contact);WEAVER, KATHRYN ELIZABETH

PROJECT_TITLE: Cancer Prevention And Control Training Grant (CAPACITY)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative / Public Health Relevance Immunobiological research findings have become increasingly relevant in surgical practice, influencing diverse surgical disciplines including oncology, transplantation, trauma, and critical care. Although the importance of immune manipulation has become an evident adjunct to the practice of surgery, and a necessary component of most advances in surgical disease, surgical training neither includes advanced immunology nor prepares surgeon-scientists to participate in immune-related research. This program aims to provide surgeons with training in advanced immunology and create surgeon-scientists capable of participating and leading in surgically relevant areas of immunobiological research.

PI_NAMEs: KIRK, ALLAN D. (contact);WEINHOLD, KENT J.

PROJECT_TERMS: Immunobiology;programs;Surgeon

PROJECT_TITLE: Advanced Immunobiology Traning Program for Surgeons


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: MEMPHIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MEMPHIS

ORG_STATE: TN

PHR: Project Narrative The overall goal of the Bridges to Baccalaureate Research Training Program at University of Memphis (UofM) is to prepare a diverse group of highly trained biomedical scientists to enhance the diversity of individuals entering the biomedical research workforce. The short-term goal of this Bridges program is to enhance research knowledge, skills, values, identity, and self-efficacy of Southwest Tennessee Community College (STCC) students from underrepresented groups in the biomedical sciences within a community of researchers. The intermediate goal is to inspire matriculation and persistence in biomedical science-related undergraduate programs at UofM, resulting in an increase in the number of students that transfer from STCC to UofM and complete the baccalaureate degree in a biomedical science.

PI_NAMEs: BLAUDOW, ROBERT A.;DE JONGH CURRY, AMY L (contact)

PROJECT_TERMS: Admission activity;Bachelor's Degree;Biomedical Research;biomedical scientist;bridge program;bridge to the baccalaureate;Communities;community college;curriculum enhancement;Degree Completion;Degree program;design;Doctor's Degree;experience;faculty research;Goals;Individual;Institution;Knowledge;matriculation;Mentorship;Outcome;peer coaching;programs;Research;Research Personnel;Research Training;Science;Scientist;Self Efficacy;skills;STEM field;Students;supplemental instruction;Tennessee;Training;Training and Education;Training Programs;transfer student;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;university student

PROJECT_TITLE: Bridges to Baccalaureate Research Training Program at The University of Memphis


ADMINISTERING_IC: OD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

ORG_STATE: MA

PHR: Project Narrative Research using the amphibian Xenopus, because of unique advantages as an experimental system, has revealed key insights in many domains of biomedical research, including cell biology, development, neurobiology, physiology and signal transduction. This proposal seeks to generate and characterize different Xenopus mutants in key genes related to human diseases using new technology, which will help provide significant insights about the causes of these diseases.

PI_NAMEs: HORB, MARKO E (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Access to Information;Age;Amphibia;animal data;Animal Housing;Animals;Bioinformatics;Biological Models;Biomedical Research;biomedical resource;Breeding;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Computer software;Custom;data management;Data Reporting;Databases;design;Development;Disease;DNA;Educational process of instructing;Educational workshop;Ensure;gene-editing approach;Generations;Genes;genome editing;Goals;Grant;human disease;human model;Image;improved;Inbreeding;Individual;insight;Location;meetings;Modeling;mutant;Neurobiology;new technology;Online Systems;Organ;Outcome;Physiology;Process;Rana;repaired;repository;Reproducibility;Research;research facility;Research Personnel;Resources;Services;sex;Signal Transduction;site-specific integration;System;Technology;Tissues;Transgenic Organisms;United States National Institutes of Health;Update;web site;Work;XenBase;Xenopus

PROJECT_TITLE: National Xenopus Resource

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-E (55)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: RALEIGH

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: 8. Narrative This Interdisciplinary Biomedical Research training program (IBRTP) addresses two critical national needs in biomedical research. First is the growing need for Veterinarians with training in biomedical research. Second is that more emphasis needs to be placed on translation of basic research advances to the clinical setting and this often requires an interdisciplinary approach.

PI_NAMEs: JONES, SAMUEL L (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Address;Area;Basic Science;Biomedical Research;career;Cellular biology;Clinical Research;Clinical Sciences;Collaborations;college;Communicable Diseases;Communication;comparative;Computational Biology;Data Science;Discipline;disease model;Educational workshop;Epidemiology;experience;Faculty;Fostering;Funding;Gastrointestinal Physiology;Genetic;Genomics;interdisciplinary collaboration;Interdisciplinary Study;interest;Laboratories;member;Mentors;Molecular Biology;multidisciplinary;Neurosciences;North Carolina;novel strategies;Pharmacology and Toxicology;Play;programs;Regenerative Medicine;Research;Research Activity;Research Personnel;Research Project Grants;responsible research conduct;Science;Series;Specialist;statistics;Students;symposium;Teacher Professional Development;Training;Training Programs;United States National Institutes of Health;Universities;Veterinary Medicine

PROJECT_TITLE: Interdisciplinary Biomedical Research Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (80)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: COLLEGE STATION

ORG_DEPT: PHYSIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Although various research institutions and clinics in the United States successfully train graduate students in cardiovascular biology, specific training in lymphatic biology is lacking. Developing the next generation of scientists is vital for the successful pursuit of treatments for lymphedema and other lymphatic dysfunction associated diseases, cardiovascular, kidney, metabolic, cancer, and brain diseases. The LYMPH Training Program at Texas A&M University will help accomplish this goal.

PI_NAMEs: MITCHELL, BRETT M;MUTHUCHAMY, MARIAPPAN  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Health;Lymphatic;Pathology

PROJECT_TITLE: LYMphatics in Pathology and Health (LYMPH)

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM (JA)]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Narrative The UNC Integrated Translational Oncology Program (UNC-iTOP) is a T32 training application from the University of North Carolina at Chapel Hill (UNC) focused on training clinicians (MDs), basic scientists (PhDs), and MD-PhD candidates in clinical/translational disease based research at the interface of clinical oncology and cancer biology using patient samples. The UNC-iTOP is unique in its focus on developing clinician/scholars in translational oncology tissue-based research, integrating 1) physicians (residents and fellows) training in Medical, Surgical, and Gynecologic Oncology with post-doctoral fellows possessing PhD degrees and 2) MD, MD-PhD, PhD pre-doctoral candidates. UNC-iTOP will provide research training support for up to two years and will support two post-doctoral and two pre-doctoral trainees per year with an anticipated ratio of 2 MD/DO/MD-PhD: 1 PhD.

PI_NAMEs: KIM, WILLIAM Y.;YEH, JEN JEN  (contact)

PROJECT_TERMS: oncology program;translational oncology


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Building on our previous work, we are proposing an innovative dual-mode breast cancer scanner combining positron emission tomography (PET) and x-ray tomosynthesis (XT). It has been shown repeatedly over the last decade by at least 11 studies that molecular imaging with clinical PET scanners can be used to gauge response of breast tumors to therapy within days. The high-resolution PET/XT scanner will provide quantitative assessment of response to breast cancer therapy for lesions <2 cm in size, which are are the most prevalent at breast cancer diagnosis, and if there is no response then there is time to test second-line and other alternative therapies and to guide the selection of an effective post-surgical adjuvant therapy.

PI_NAMEs: DOLINSKY, SERGEI ;KINAHAN, PAUL E. (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: Acceleration;Adjuvant Therapy;Adoption;Algorithms;Alternative Therapies;Anatomy;attenuation;Breast;breast cancer diagnosis;Breast Cancer Patient;Breast Cancer therapy;breast imaging;cancer imaging;cancer therapy;Clinical;Clinical Oncology;clinical practice;Clinical Trials;Clinical/Radiologic;Consultations;Coupled;Data;Dedications;design;detector;Development;Diagnosis;Diagnostic;Diameter;Disease;Dose;effectiveness evaluation;Electronics;Ensure;Evaluation;Excision;Explosion;fluorodeoxyglucose;follow-up;FPS-FES Oncogene;Geometry;high resolution imaging;Image;image reconstruction;imaging study;imaging system;innovation;interest;Lesion;Malignant Breast Neoplasm;Mammary Neoplasms;Measurement;Measures;Mechanics;Methods;Modality;Modification;molecular imaging;Neoadjuvant Therapy;Neoplasm Metastasis;Operative Surgical Procedures;Patient imaging;Patients;Performance;personalized medicine;phase II trial;Photons;Positioning Attribute;Positron-Emission Tomography;predicting response;Primary Neoplasm;Prior Therapy;prototype;quantitative imaging;radiotracer;Recurrence;Resected;Resolution;response;Roentgen Rays;Role;Schedule;Source;Specimen;Stains;System;Systems Development;targeted treatment;Technology;Testing;Time;Tissue Stains;tomosynthesis;Translations;treatment optimization;treatment response;tumor;uptake;Variant;Work;X-Ray Computed Tomography

PROJECT_TITLE: Integrated PET+DBT for optimization of breast cancer therapy

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ORG_CITY: SAN LUIS OBISPO

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CALIFORNIA POLY STATE U SAN LUIS OBISPO

PHR: The persistent lack of diversity among scientists in the biomedical field limits our ability to address the complex array of health problems and disparities that affect our nation and the world today. BtB at Cal Poly is a training program that incorporates best practices from evidence-based training programs, providing support for students attending community college to transfer and complete a baccalaureate degree in biomedical sciences. The multi-faceted program consists of one year of research skills training and academic support at a community college, followed by a robust curriculum post-transfer that includes mentored research experiences, didactic instruction on conceptual and technical research skills, mentoring teams, and specialized curriculum emphasizing the prosocial value of biomedical research, building identity as a scientist, fostering a deep understanding of health equity, and developing knowledge and skills to direct research towards current health challenges.

PI_NAMEs: FOX, ALICIA ;HAGOBIAN, TODD ALAN (contact);KEADLE, SARAH KOZEY

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Bachelor's Degree;Biomedical Research;bridge to the baccalaureate;California;Collaborations;college;community college;Degree Completion;design;Disabled Persons;Economically Deprived Population;Educational Curriculum;Ensure;Event;experience;Graduation Rates;Grant;improved;Individual;Inequality;Institution;Measurable;Mentors;Mission;people of color;Process;programs;recruit;Research;responsible research conduct;Science;Self Efficacy;skills;skills training;Societies;socioeconomic disadvantage;Structure;Students;Talents;Training;Training Programs;Universities;Woman

PROJECT_TITLE: Bridges to the Baccalaureate at Cal Poly

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: OVERALL NARRATIVE The mission of this Penn PO1 Center on “Mechanisms underlying heterogeneity of cognitive outcome in synucleinopathy” is to understand why the same underlying core pathology – inclusions of alpha-synuclein (aSyn) – can manifest in such different ways, leading to important differences in quality of life for patients with Lewy body disorders (LBD) such as dementia with Lewy bodies (DLB), Parkinson’s Disease (PD), and Alzheimer’s Disease with Lewy bodies (LBD+AD). By investigating both the characteristics of the disease protein aSyn and the characteristics of the hosts (individual LBD patients), and by using human tissues, neuronal models, and animal models, we aim to develop new therapeutic targets to delay or prevent Alzheimer Disease Related Dementia.

PI_NAMEs: CHEN-PLOTKIN, ALICE S (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Animal Model;Autopsy;Behavior;Biological;Biological Markers;Brain;brain tissue;Cells;Characteristics;Clinical;Cognition;Cognitive;Collaborations;Communities;Complement;cost;CRISPR/Cas technology;Data;data management;data sharing;Dementia;Dementia with Lewy Bodies;design;Development;Digital biomarker;digital pathology;Disease;DNA;Etiology;experimental study;FDA approved;Genes;Genetic;genetic manipulation;Genetic Status;genome wide association study;Genomics;Goals;Healthcare Systems;Heterogeneity;Human;human data;human disease;human tissue;Impaired cognition;in vivo;Individual;Induced pluripotent stem cell derived neurons;Integration Host Factors;Investigation;Lewy Bodies;Lewy Body Disease;meetings;Mission;Modeling;Molecular;Molecular Conformation;mouse model;Nature;Nerve Degeneration;Neurobehavioral Manifestations;Neurons;new therapeutic target;novel therapeutic intervention;Outcome;Parkinson Disease;Parkinson's Dementia;Pathologic;Pathology;Patients;Pattern;Phenotype;Play;pre-formed fibril;Prevalence;prevent;programs;Proteins;Proteomics;Quality of life;Recombinants;recruit;Research;Research Personnel;Research Project Grants;Resources;Role;Route;Sampling;Senile Plaques;Services;shared database;statistics;structural imaging;synergism;synucleinopathy;tau aggregation;tau Proteins;Techniques;Testing;therapeutic target;translational scientist;transmission process;uptake;Variant

PROJECT_TITLE: Mechanisms Underlying Heterogeneity of Cognitive Outcomes in Synucleinopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-8 (M1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PROJECT_TERMS: Address;Advisory Committees;Advocate;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Area;Basic Science;Biological Markers;Brain;brain tissue;Caregivers;Characteristics;Clinical;Cognitive;Collaborations;Collection;Communication;Communities;Data;data management;data sharing;Dementia with Lewy Bodies;Development;Disease;Ensure;falls;FDA approved;Fostering;General Population;Genetic;Goals;Heterogeneity;Human;human subject;Impaired cognition;Individual;insight;Institution;Institutional Review Boards;International;Lewy Bodies;Lewy Body Disease;medical schools;meetings;member;Mentorship;Mission;mixed dementia;Nature;Neurodegenerative Disorders;Outcome;Parkinson Disease;Parkinson's Dementia;Pathologic Processes;Pathology;Patients;Pattern;peer;Pennsylvania;Persons;Policies;Population;programs;Protocols documentation;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Sampling;Scientist;social media;statistics;Symptoms;synergism;synucleinopathy;targeted treatment;therapy development;translational scientist;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PI_NAMEs: WEINTRAUB, DANIEL  (contact)

PROJECT_TERMS: Address;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;Autopsy;Biological Markers;biomedical referral center;Blood;Brain;brain tissue;CAMLG gene;Clinical;Clinical assessments;clinical center;Clinical Data;clinical diagnosis;Cognition;Cognitive;cohort;Collaborations;Common Data Element;Consensus;Consent;Data;Data Collection;data management;data sharing;Databases;Dedications;Dementia;Dementia with Lewy Bodies;Diagnosis;Diagnostic;DNA;Education;follow-up;Foundations;Genetic;Goals;Heterogeneity;Home;Human;human data;Impaired cognition;in vivo;Interdisciplinary Study;International;Lewy Bodies;Lewy Body Disease;Life;Link;Magnetic Resonance Imaging;Medical center;medical schools;mild cognitive impairment;mixed dementia;Motor;motor symptom;Movement Disorders;Multicenter Studies;National Institute of Neurological Disorders and Stroke;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuroimaging;Neuropsychological Tests;Onset of illness;Outcome;Parkinson Disease;Parkinson's Dementia;Participant;Pathologic;Pathologic Processes;Pathology;patient retention;Patients;Pattern;Pennsylvania;Philadelphia;Plasma;prevent;Process;Program Research Project Grants;programs;recruit;Research;Resources;RNA;Sampling;Single Nucleotide Polymorphism;Site;Source;Spinal Puncture;statistics;synucleinopathy;Tissue Banks;Tissues;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Variant;Work

PROJECT_TITLE: Core B: Clinical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PI_NAMEs: LEE, EDWARD BYUNG-HA (contact)

PROJECT_TERMS: Affect;age related neurodegeneration;aging brain;alpha synuclein;Alzheimer's Disease;Amyloid beta-Protein;Archives;Autopsy;Basic Science;Biochemical;Biological;biomarker discovery;Blood Vessels;Brain;Brain region;brain tissue;Cells;Cerebrospinal Fluid;Classification;Clinical;clinical phenotype;Cognitive;Communities;comorbidity;Data;Databases;Dementia;Deposition;Diagnosis;Disease;disorder risk;DNA;DNA Library;Doctor of Medicine;Doctor of Philosophy;Documentation;Experimental Models;Extracellular Space;Fostering;Freezing;Generations;Genetic;Genetic Heterogeneity;genome resource;genomic data;Genotype;Goals;Heterogeneity;Human;human disease;Impaired cognition;Individual;International;Lesion;Lewy Bodies;Lewy Body Disease;Lewy neurites;Modeling;Monitor;Morphology;Neurodegenerative Disorders;Neurofibrillary Tangles;neuropathology;Neuropil;Outcome;Pathologic;Pathology;Pathway interactions;Peptides;Plasma;Program Research Project Grants;Property;protein aggregation;protein TDP-43;Proteins;Qualifying;Recombinants;Research;Research Personnel;Research Project Grants;research study;Resources;Sampling;Senile Plaques;Specimen;Standardization;synucleinopathy;tau Proteins;Tissue Banks;Tissues

PROJECT_TITLE: Core C: Resource Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

PI_NAMEs: XIE, SHARON XIANGWEN (contact)

PROJECT_TERMS: Bioinformatics;Biological Markers;Biometry;Clinical;Cognitive;Collaborations;Computer software;Computer Systems;Data;Data Analyses;data management;data quality;data sharing;Databases;Development;Fostering;Generations;Genetic;Genomics;Goals;Grant;Health Policy;Heterogeneity;Image;Lewy Body Disease;Manuscripts;medical schools;Methodology;multimodal data;National Institute on Aging;neuropathology;operation;Outcome;Pennsylvania;Play;Preparation;Procedures;Program Research Project Grants;Proteomics;Publications;Quality Control;Questionnaire Designs;relational database;Research;Research Design;Research Personnel;Research Project Grants;Resources;Role;Sample Size;Security;Services;Site;Statistical Methods;statistics;support network;synucleinopathy;United States National Institutes of Health;Universities

PROJECT_TITLE: Core D: Data Management and Statistics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PI_NAMEs: IRWIN, DAVID JOHN (contact)

PROJECT_TERMS: Aging;alpha synuclein;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Anatomy;Atrophic;Attention;Autopsy;Biological;Biological Markers;Brain;Brain region;brain tissue;Cell model;Cells;Central Nervous System;Classification;Clinical;Clinical Data;Cognitive;cognitive function;cohort;Complex;connectome;Data;data modeling;Data Set;Dementia;Dementia with Lewy Bodies;Development;Diffusion;digital;Disease;endophenotype;Experimental Models;Future;Genetic;Graph;graph theory;Heterogeneity;Histology;Histopathology;Human;imaging biomarker;Impaired cognition;in vivo;in vivo imaging;insight;Language;language impairment;Lewy Body Dementia;Lewy Body Disease;Life;Magnetic Resonance Imaging;Memory;Memory impairment;Methods;Microscopic;Modeling;Motor;multimodality;Multiple System Atrophy;Nerve Degeneration;Nervous System;neural;Neurobehavioral Manifestations;Neurocognitive;neurodegenerative dementia;Neuronal Dysfunction;Neurons;novel;Outcome;Parkinson Disease;Parkinson's Dementia;Pathologic;Pathology;Pathway Analysis;Patients;Pattern;Phenotype;Population;predictive modeling;Prognostic Marker;Program Research Project Grants;prospective;Resolution;Sampling;Science;Staging System;Structure;Subgroup;symposium;Symptoms;synucleinopathy;System;tau interaction;tau Proteins;Techniques;Work

PROJECT_TITLE: Project I: Alpha Synucleinopathy in the Human Brain Connectome


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PI_NAMEs: LEE, VIRGINIA M (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Adopted;alpha synuclein;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Amyloid;Antibodies;Architecture;Autophagocytosis;Behavior;beta pleated sheet;Biochemical;Biological;BODIPY;Braak's hypothesis;Brain;Brain Diseases;brain tissue;Buffers;Cell Nucleus;Cells;Chemicals;Clathrin;Clinical;Cognitive;Cognitive deficits;Crowding;Cytoplasmic Inclusion;Defect;Dementia with Lewy Bodies;Detergents;Dextrans;Disease;Dyes;Dynamin;Environment;Event;F-Actin;fluorophore;Functional disorder;Genetic;Goals;Guanosine Triphosphate Phosphohydrolases;Heterogeneity;Human;Human body;Image;Incubated;inhibitor;insight;Label;Laboratories;Lewy Bodies;Lewy Body Disease;Lewy neurites;light microscopy;Link;loss of function mutation;Lysosomes;LysoTracker;Microscopy;Modeling;Molecular;Molecular Conformation;Molecular Profiling;Multiple System Atrophy;nanoscale;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;Nuclear Translocation;Oligodendroglia;Outcome;Parkinson Disease;Parkinson's Dementia;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Phagocytosis;Pharmaceutical Preparations;Phenotype;Play;Post-Translational Protein Processing;Potassium Channel;pre-formed fibril;preservation;Process;Proteins;Recombinants;Research Personnel;Resolution;Risk;Role;Route;Senile Plaques;Source;Structure;synucleinopathy;transcription factor;Work;wortmannin

PROJECT_TITLE: Project II: Deciphering the Signatures of Pathological Changes on Alpha-Synuclein


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Affect;Alleles;alpha synuclein;Area;Biological Assay;Biological Markers;biomarker identification;biomarker signature;Blood Screening;Brain;Brain Stem;brain tissue;causal variant;Cells;Characteristics;Clinical;clinical diagnosis;clinical research site;Cognitive;cohort;cost;CRISPR/Cas technology;Data;Dementia;dementia risk;Dementia with Lewy Bodies;Deposition;Development;Disease;disorder risk;Environment;Etiology;Exhibits;Family;Genes;Genetic Markers;Genetic Risk;Genetic Screening;Genetic Variation;genome wide association study;genomic locus;Genomics;Goals;Hallucinations;Healthcare Systems;Heterogeneity;Impaired cognition;Individual;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;insight;Interruption;Investigation;Knock-out;Lewy Body Disease;Mendelian randomization;Motor;motor symptom;Neurobehavioral Manifestations;Neurons;neuropathology;new therapeutic target;Normal tissue morphology;Onset of illness;Outcome;Parkinson Disease;Parkinson's Dementia;Pathologic;Pathology;Patients;Pattern;phenomenological models;Phenotype;Plasma;Play;Probability;protein biomarkers;Proteins;Proteomics;Quality of life;Quantitative Trait Loci;Reporting;Risk;risk variant;Role;Route;Sampling;Severity of illness;synucleinopathy;System;Techniques;Testing;transmission process;Untranslated RNA;uptake;Variant;Work

PROJECT_TITLE: Project III: Heterogeneity of Outcomes in Synucleinopathies: Insights from Genomics and Proteomics


PI_NAMEs: LUK, KELVIN C (contact)

PROJECT_TERMS: Address;Affect;alpha synuclein;Alzheimer's disease patient;Animals;Autopsy;Behavioral;Cells;Central Nervous System;clinical heterogeneity;clinical phenotype;Cognitive;Corpus striatum structure;dementia risk;Dementia with Lewy Bodies;Disease;Disease Progression;Disease susceptibility;Dissection;Dose;Enteric Nervous System;Evolution;examination questions;Functional disorder;gene product;Genes;Genetic;genetic risk factor;Heterogeneity;Hippocampus;Histologic;Human;in silico;in vivo;in vivo Model;Individual;Injections;insight;Knowledge;Lewy Bodies;Lewy Body Disease;Lewy neurites;Link;Mammals;Modeling;Molecular;Motor;mouse model;Mus;Mutation;Nerve Degeneration;Neuroanatomy;Neurons;novel;Outcome;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Peripheral Nervous System;Phenotype;Play;pre-formed fibril;Predisposition;Process;Proteins;receptor-mediated signaling;Recombinants;REM Sleep;response;risk variant;role model;Sleep disturbances;spatiotemporal;synucleinopathy;System;Time;Tissues;tool;Toxic effect;Variant;Work

PROJECT_TITLE: Project IV: In Vivo Dissection of Genetic Modifiers on Different Stages of Synucleinopathy


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative There is an ongoing, severe shortage of veterinarian-scientists with the research expertise necessary to pursue careers as independent investigators in biomedical research. These individuals are critical to effectively translating biomedical research discoveries made in animal models into new methods for the diagnosis and treatment of human disease. This "Comparative Medicine and Pathology Training" program at the University of Minnesota will use and improve our established mechanisms of providing a robust research training experience to DVMsNMDs to increase the number of veterinarian-scientists working successfully in biomedical research fields and conducting research around the "One Health" concept for the ultimate benefit of human health.

PI_NAMEs: BROWN, DAVID R;CARLSON, CATHY S.;FURROW, EVA  (contact);GUEDES, ALONSO

PROJECT_TERMS: comparative;Medicine;Pathology;Training


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Whooping cough (pertussis) is a re-emerging public health crisis responsible for the death of over 150,000 infants annually. We have identified a currently licensed drug that protects against disease, but has off-target effects. We have identified 3 proteins, one of which is produced by mice in response to this drug, the other two are blocked by the drug, which we believe may control symptoms associated with disease.

PI_NAMEs: SKERRY, CIARAN  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Agonist;airway epithelium;Amplifiers;anti-microbial peptide;Antibiotic Therapy;Antibiotics;antimicrobial;associated symptom;Attenuated;bactericide;Binding;Biological Assay;Biosensor;Bordetella pertussis;Cause of Death;Cell Separation;cell type;Cells;Cessation of life;Characteristics;Communicable Diseases;Complex;Core Facility;Coughing;cytokine;cytotoxic;Cytotoxin;Data;Development;differential expression;Disease;Elements;Equilibrium;Family;Flow Cytometry;Genes;Goals;Gram-Negative Bacteria;Immunization Programs;in vitro Assay;Infant;Inflammation;Inflammatory;Inflammatory Response;inhibitor;insight;Kinetics;Knockout Mice;Licensing;Ligands;Lung;Mass Vaccinations;Measures;Mediating;Mus;Myeloid Cells;next generation;novel therapeutics;Papio;Pathogenesis;Pathology;Pattern recognition receptor;Peptidoglycan;peptidoglycan monomer;peptidoglycan recognition protein;Pertussis;Pharmaceutical Preparations;prevent;Proteins;Public Health;Pulmonary Inflammation;Pulmonary Pathology;receptor;Receptor Activation;Recombinants;response;Role;single-cell RNA sequencing;Sphingosine-1-Phosphate Receptor;Testing;Therapeutic;Tissues;Trachea;transcriptomics;Virulence Factors;Work

PROJECT_TITLE: Pertussis inflammation is mediated by a balance between peptidoglycan recognition proteins-1 and -4

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE – Overall The Translational Research Program in Colorectal Cancer Disparities (TRPCD) will conduct innovative translational research that is focused on the development of novel clinically impactful strategies to eliminate persistent racial and ethnic disparities in colorectal cancer incidence and mortality. The proposed four research projects leverage large racially and ethnically diverse study populations and highly annotated biospecimens; are led by a world-class investigator team with expertise in basic science, epidemiology, biostatistics, clinical and translational research, minority health, and cancer disparities; and are supported by three critical cores. Through these efforts and future projects and investigators funded by our Developmental Research Program and Career Enhancement Program, TRPCD will actively pursue a robust set of horizontal and vertical collaborations.

PI_NAMEs: LI, CHRISTOPHER I;PETERS, ULRIKE  (contact);THOMAS, TIMOTHY K

PROGRAM_OFFICER_NAME: HUBBARD, LEAH

PROJECT_TERMS: Address;African American;African American population;Alaska Native;Alaska Native population;anti-cancer research;Basic Science;biobank;Bioinformatics;Biological;Biological Markers;Biology;Biometry;Biotechnology;Cancer Center;Cancer Etiology;cancer health disparity;Cancer Survivor;career;Cessation of life;Characteristics;Clinical;Clinical Data;Clinical Research;Clinical Sciences;clinical trial enrollment;Clinical Trials;Collaborations;colon cancer patients;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;Data Set;Death Rate;Development;Diagnosis;Dimensions;Disease;Disparity;Early Diagnosis;effectiveness testing;Ensure;Epidemiology;ethnic disparity;ethnic diversity;Ethnic Population;Etiology;Evaluation;Foundations;Funding;Future;Genetic;genetic epidemiology;Genomics;Germ Lines;Goals;health disparity;Healthcare;high risk;Hispanic;improved;Incidence;Indolent;innovation;Intervention;Leadership;lifestyle factors;Medical History;microbial;microbiome;minority disparity;Molecular;Molecular Genetics;molecular marker;Morbidity - disease rate;mortality;multiple omics;Native Americans;new technology;new therapeutic target;Not Hispanic or Latino;novel;novel therapeutic intervention;Pathology;patient population;Patients;Phase;Play;Population;Population Heterogeneity;Population Sciences;predictive modeling;Prevention;Prevention strategy;Primary Prevention;programs;racial disparity;racial diversity;racial population;recruit;Research;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;risk prediction model;risk stratification;Role;screening;Selection for Treatments;study population;Talents;Technology;Testing;Translational Research;translational research program;treatment response;tumor;United States;Variant

PROJECT_TITLE: Translational Research Program in Cancer Differences across Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-6 (M1)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE – Administrative Core (AC)  The successful functioning of our Translational Research Program in Cancer Differences across Populations (TRPCDP) is highly dependent upon a capable and effective Administrative Core (AC). The AC will be vital for providing the requisite foundation for effective implementation of TRPCDP’s scientific and translational goals. This Core will provide overall leadership and administrative support, program management, incorporation with existing programs and shared resources, infrastructural support, communication within and across TRPCDP investigators and partnering institutions, and evaluation of all TRPCDP activities and components.

PI_NAMEs: PETERS, ULRIKE  (contact)

PROJECT_TERMS: 3-Dimensional;African American;Agreement;Alaska Native;Bioinformatics;Biometry;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer Patient;career;Collaborations;Colorectal Cancer;Communication;community advisory board;Consult;Data;data management;Death Rate;Development;Disparity;Ensure;ethnic diversity;Ethnic Population;Evaluation;experience;Fostering;Foundations;Funding;Grant;Health;Hispanic;Incidence;industry partner;Infrastructure;Institution;Leadership;Letters;Manuscripts;meetings;Monitor;National Cancer Institute;Office of Administrative Management;organizational structure;Pathology;patient population;Patients;Population Heterogeneity;Preparation;programs;Progress Reports;racial diversity;racial population;Regulation;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Specialized Center;Specimen;success;translational goal;translational research program;tribal health;Update


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Cost Effectiveness Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Microbiome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE of Project 1  The better performance of current polygenic risk scores (PRS) in individuals of European ancestry compared to other genetic ancestral groups creates a major challenge with respect to their broad clinical dissemination, as these PRS have the potential to increase existing differences in colorectal cancer (CRC) rate. We will use a novel strategy that leverages single-cell multi-omic data to develop and validate a PRS that predicts CRC risk across different ancestral groups. We will also evaluate the cost-effectiveness of our PRS and estimate optimal screening strategies in terms of balanced access and efficiency for different risk groups that account for differences in CRC incidence, mortality, and risk factor profiles across different genetic ancestral groups.

PROJECT_TERMS: Address;African American population;Age;Cancer Burden;cancer diagnosis;Cancer Etiology;cancer health disparity;cell type;Cells;Cessation of life;Chromatin;Clinical;clinical care;Code;Colon;Colorectal;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;Communities;cost;cost comparison;cost effective;cost effectiveness;cost-effectiveness evaluation;Data;Data Analyses;Death Rate;deep learning;Development;Disparity;early onset colorectal cancer;Enhancers;Environmental Risk Factor;Equity;Ethics;ethnic difference;ethnic diversity;ethnic minority population;Ethnic Origin;Ethnic Population;experience;Family;Family history of;Frequencies;functional genomics;Gene Expression;General Population;Genetic;genetic epidemiology;Genetic Research;Genetic Risk;genetic risk factor;Genetic study;genetic testing;genetic variant;genome wide association study;genome-wide;genomic data;Guide prevention;health inequalities;Health Personnel;high risk;Impairment;improved;Incidence;Individual;Intervention;Lead;Leadership;Linkage Disequilibrium;Machine Learning;machine learning method;microbiome;Modality;Modeling;models and simulation;mortality;Multiomic Data;multiple omics;Not Hispanic or Latino;novel;novel strategies;Online Systems;Patient Self-Report;Performance;personalized intervention;personalized screening;Persons;Physicians;Policy Maker;polygenic risk score;Population;Population Heterogeneity;Positioning Attribute;predictive tools;Prevention;prospective;Race;racial difference;racial diversity;racial minority population;racial population;Recording of previous events;Research Personnel;Risk;Risk Estimate;Risk Factors;risk prediction;risk prediction model;risk stratification;risk variant;Sample Size;screening;screening guidelines;sex;Statistical Methods;Subgroup;Technology;Time;Tissues;Transcriptional Regulation;translational research program;Translations;Underrepresented Populations;United States;Update;Use Effectiveness;Variant

PROJECT_TITLE: Project 1: Racial and ethnic differences in the intra-tumoral microbiome: Impact on colorectal cancer mortality and clinicopathologic correlates


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE  This project aims to discover novel spatially resolved biomarkers of lethal colorectal cancer and response to both first-line therapy and immunotherapy in different patient groups. It will also develop and validate predictors of colorectal cancer specific mortality and treatment response across different patient population groups.

PI_NAMEs: LI, CHRISTOPHER I (contact)

PROJECT_TERMS: Address;African American;African American population;Alaska Native;Alaska Native population;Biological Assay;Biological Markers;Biological Sciences;biomarker identification;biomarker panel;cancer cell;cancer health disparity;Carcinoembryonic Antigen;Cells;checkpoint therapy;Clinical;clinical decision-making;clinically relevant;colon cancer patients;Colorectal Cancer;colorectal cancer risk;colorectal cancer treatment;Colorectal Neoplasms;Data;Death Rate;Development;Diagnostic;Disease Progression;Disparity;ethnic diversity;Ethnic Origin;Ethnic Population;Evaluation;experience;Healthcare;high risk;Hispanic;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immunofluorescence Immunologic;Immunotherapy;improved;Incidence;Infrastructure;innovation;insight;liquid crystal polymer;long-standing disparities;Malignant Neoplasms;Modality;Molecular;Molecular Profiling;Monitor;mortality;Native Americans;Not Hispanic or Latino;novel;novel marker;novel therapeutic intervention;Outcome;patient population;patient stratification;Patients;Performance;Population Heterogeneity;predicting response;Prediction of Response to Therapy;Prognostic Marker;Proteomics;Race;racial diversity;racial population;Recurrence;Resolution;response;risk prediction;risk prediction model;Sampling;screening;Selection for Treatments;Sensitivity and Specificity;spatial relationship;Stage Grouping;standard of care;Survival Rate;Translating;translational impact;translational potential;translational research program;treatment response;tumor;tumor microenvironment;Tumor Tissue;United States;Validation;Work

PROJECT_TITLE: Project 2: Discovery and validation of novel molecular and immune predictors of colorectal cancer mortality and response to treatment in racially and ethnically diverse patient populations


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE  The burden of colorectal cancer incidence and mortality varies greatly across population groups. In this project, we will examine the role of bacteria in colorectal cancer across population groups to identify differences in the presence and distribution of different bacteria – individually and in combination. The findings from this work will help us better tailor cancer treatments and early detection in the future to address colorectal cancer differences across population groups.

PI_NAMEs: HULLAR, MEREDITH  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Actinomyces;Address;Adult;African American;African American population;Age;Alaska Native;Alaska Native population;Antibiotics;Area;Artificial Intelligence;Bacteria;Bacteroides;Biological Assay;Cancer Burden;cancer diagnosis;Cancer Etiology;cancer health disparity;cancer survival;cancer therapy;Cessation of life;Classification;Clostridium;Colon;colon cancer patients;Colorectal;Colorectal Cancer;Colorectal Neoplasms;Communities;Complex;Consensus;Data;data resource;Death Rate;Diagnosis;Diet;digital;Disparity;disparity reduction;DNA Damage;Down-Regulation;Early Diagnosis;Early treatment;Environmental Exposure;Epithelial Cells;Equilibrium;ethnic difference;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnic Population;Evaluation;Exhibits;experience;Fusobacterium;Fusobacterium nucleatum;Future;Goals;gut bacteria;gut microbiome;gut microbiota;Health;Hispanic;Human;Incidence;Individual;Infrastructure;Investigation;learning strategy;Machine Learning;machine learning model;Malignant Neoplasms;Measures;member;microbial;microbial community;microbial signature;microbiome;molecular subtypes;mortality;Native Americans;Natural History;Neisseria;Not Hispanic or Latino;novel;novel strategies;Outcome;outcome disparities;Participant;Pathogenicity;Pathway interactions;Patients;Phase;Population;Population Group;Prevalence;Prognosis;Race;racial difference;racial disparity;racial diversity;racial population;Reporting;Research;Resources;Risk;Role;sex;Shoulder;Site;Structure;Testing;Tissues;TP53 gene;Translating;translational research program;treatment strategy;tumor;Tumor Markers;tumor microbiome;tumor progression;tumorigenesis;United States;Work

PROJECT_TITLE: Project 3: Racial and ethnic differences in the intra-tumoral microbiome: Impact on colorectal cancer mortality and clinicopathologic correlates


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Orphan Drug;Patient Safety;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

PHR: PROJECT NARRATIVE – Project 4  We propose to conduct a randomized controlled trial of time-restricted eating (TRE) during neoadjuvant treatment in 100 AN patients with rectal cancer at the ANMC. We will examine whether TRE improves pathological complete response rate, reduces treatment related toxicities, improves health-related quality of life, and adherence. Changes in selected cancer-related blood-based and tumor-based markers by interventional arm, and differences across population groups, will be examined through a horizontal collaboration with the CHRONO Trial.

PI_NAMEs: FIGUEIREDO, JANE C. (contact)

PROJECT_TERMS: Adherence;Adverse event;African American;Alaska Native;Alaska Native population;anti-cancer treatment;Apoptosis;arm;Asian;Autophagocytosis;Biological Markers;Blood;blood-based biomarker;cancer cell;cancer health disparity;Cancer Patient;cancer therapy;cardiometabolism;Cell Proliferation;Cells;Chemotherapy and/or radiation;Clinical;Clinical Research;Clinical Trials;Collaborations;Colorectal Cancer;Combined Modality Therapy;Common Terminology Criteria for Adverse Events;Communities;comparison control;Comprehensive Health Care;Continuous Glucose Monitor;cytotoxic;Data;Death Rate;dietary restriction;Disparity;DNA Damage;Eating;Environment;ethnic disparity;ethnic diversity;Ethnic Population;experience;Fasting;Glucose;Goals;Grant;Growth;Health;health disparity;health related quality of life;Health Services;high risk;Hispanic;Hour;IGFBP3 gene;improved;In complete remission;Incidence;Individual;innovation;Insulin;insulin sensitivity;Insulin-Like Growth Factor I;interest;Intermittent fasting;Intervention;Leukocytes;Life;lifestyle intervention;Los Angeles;Malignant Neoplasms;Medical center;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic rate;nano-string;Neoadjuvant Therapy;neoplastic cell;Not Hispanic or Latino;novel;Nutrient;Operative Surgical Procedures;Outcome;Participant;Pathologic;patient population;Patients;Phase II Clinical Trials;phase II trial;Population;Population Heterogeneity;preclinical study;Proteins;Quality of life;racial disparity;racial diversity;racial population;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Rectal Cancer;Rectum;Regimen;Research Infrastructure;Resistance;response;response biomarker;Risk;service organization;Stress;Testing;theories;Time-restricted feeding;tissue biomarkers;Tissues;Toxic effect;translational research program;treatment arm;treatment duration;treatment effect;treatment response;Treatment-related toxicity;tribal health;tumor;Tumor Tissue;Variant;Water

PROJECT_TITLE: Project 4: Effect of Meal Timing during Cancer Treatment in Alaska Native Patients - A Randomized Clinical Trial


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Social Determinants of Health

PHR: PROJECT NARRATIVE of the Biospecimen and Pathology Core (BPC)  This Biospecimen and Pathology Core (BPC) will develop a one-of-a-kind colorectal cancer (CRC) biorepository that provides the critical infrastructure needed for the collection, processing, management, and governance of biospecimens and clinical and epidemiological data from CRC patients and non-diseased participants. These biospecimens and data will be used by the SPORE projects, are available for use by Career Enhancement and Developmental Research Programs and can be used to support outside collaborations to advance the translational science for CRC. The BPC will also enable access to state-of-the-art laboratory technologies and provide expertise in tissue-based assays and biomarker analyses.

PI_NAMEs: KOEHNE, AMANDA L (contact)

PROJECT_TERMS: Address;Agreement;Area;biobank;Biological Assay;Biological Markers;Biological Specimen Banks;Blood;Board Certification;cancer health disparity;career;cell preparation;Clinical;Clinical Data;Collaborations;Collection;colon cancer patients;Colorectal Cancer;Data;Data Collection;data harmonization;Death Rate;Development;digital imaging;DNA;Ensure;epidemiologic data;Epidemiology;epidemiology study;ethnic diversity;Ethnic Population;experience;Feces;Formalin;Freezing;health data;Incidence;Infrastructure;innovation;Institution;Institutional Review Boards;laboratory equipment;Life Style;Measures;Medical;nano-string;new technology;Normal tissue morphology;Not Hispanic or Latino;Outcome;Paraffin Embedding;Participant;Pathologist;Pathology;Persons;Phase;Pilot Projects;Population Heterogeneity;Process;Program Research Project Grants;programs;Protocols documentation;Quality Control;racial diversity;racial population;repository;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;Saliva;sample collection;sequencing platform;single cell genomics;single-cell RNA sequencing;social health determinants;Specimen;Stains;Standardization;success;System;Technology;Tissues;Translational Research;translational research program;Tribes;tumor;Tumor Tissue;Urine;Work

PROJECT_TITLE: Core B: Biospecimen and Pathology Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: HSU, LI  (contact)

PROJECT_TERMS: Accounting;anti-cancer research;Area;Bioinformatics;bioinformatics tool;Biological;Biological Assay;Biological Process;Biometry;blood-based biomarker;cancer health disparity;career;Cells;Characteristics;Chromatin;clinical practice;Clinical Trials;Collaborations;Colorectal Cancer;colorectal cancer risk;Complex;computerized data processing;computerized tools;Data;Data Analyses;Data Collection;data quality;design;Development;Diagnosis;digital;disorder risk;Disparity;Early Diagnosis;Economics;Ensure;Environmental Exposure;ethnic disparity;Ethnic Origin;Ethnic Population;experience;Gene Expression;Genetic;Genetic Variation;genome-wide;genomic data;genomic profiles;Genomics;Germ Lines;Goals;high dimensionality;Incidence;Joints;Knowledge;Malignant Neoplasms;Manuscripts;Measures;Methodology;Methods;microbiome;Molecular;Molecular Profiling;Monitor;mortality;novel;novel strategies;Observational Study;Outcome;Pathology;Phase;Play;Politics;Population Heterogeneity;pressure;Prevention;Prevention approach;Process;Prognosis;programs;Protocols documentation;Quality Control;Race;racial disparity;racial population;Records;Reporting;Research;Research Activity;Research Design;Research Personnel;risk prediction;Role;Shapes;single cell ATAC-seq;Site;social;social health determinants;Statistical Methods;Structure;survival outcome;survivorship;Technology;tool;transcriptome sequencing;Translational Research;translational research program;treatment response;treatment strategy;tumor;tumor-immune system interactions;Variant

PROJECT_TITLE: Core C: Biostatistics and Bioinformatics Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE of the Developmental Research Program (DRP)  The Developmental Research Program (DRP) is a key component of the long-term success of our Translational Research Program in Cancer Differences across Populations. It will swiftly fund innovative and impactful DRP projects focused on translational cancer research with the potential to develop into full research projects. The DRP will be a catalyst to accelerate cutting edge cancer translational research that aims to understand the underlying biological drivers for cancer differences and develop interventions and treatments that will lead to reduction in the morbidity and mortality of cancer.

PI_NAMEs: GRADY, WILLIAM MALLORY (contact)

PROJECT_TERMS: Acceleration;Address;Advertising;Alaska Native;Area;Award;Bioinformatics;Biological;Biological Specimen Banks;Biometry;Black race;Cancer Center;cancer health disparity;Cancer Research Project;cancer type;career;catalyst;Collaborations;Colorectal Cancer;community advisory board;Data;data management;Dedications;Development;Discipline;Disparity;Early Diagnosis;Ensure;Epidemiology;equity, diversity, and inclusion;ethnic diversity;Evaluation;experience;Fostering;Funding;Grant;Growth;Guidelines;Health;high reward;high risk;improved;Infrastructure;innovation;Institution;Intervention;Lead;Malignant Neoplasms;Manuscripts;member;Mentorship;minority investigator;Minority-Serving Institution;Mission;Molecular Biology;Monitor;Morbidity - disease rate;mortality;new technology;novel;Oral;Outcome;Pathology;Peer Review;Phase;Pilot Projects;Population Heterogeneity;Primary Prevention;Prognosis;Program Research Project Grants;programs;racial diversity;Research;Research Design;Research Personnel;Research Project Grants;Resources;risk prediction;Secondary Prevention;Statistical Data Interpretation;Structure;success;survivorship;Technology;Therapeutic;Training;Translational Research;translational research program;translational study;tribal health;Underrepresented Minority;Underserved Population;United States;United States National Institutes of Health

PROJECT_TITLE: Developmental Research Project


PHR: PROJECT NARRATIVE of the Career Enhancement Program (CEP)  Our Translational Research Program in Cancer Differences across Populations (TRPCDP) Career Enhancement Program is an essential component of our SPORE. Its primary purpose is to attract and support new scientists from different disciplines (clinical, basic science, and population science) to the field of translational research aimed at meaningfully reducing long-standing differences in cancer incidence and mortality across population groups and identifying factors that drive differential outcomes among population groups. Cornerstones of our program include identifying and providing multi-disciplinary mentors, assigning sponsors, and providing opportunities for leadership development as appropriate.

PROJECT_TERMS: Academy;Address;Advocate;African American;Alaska Native;Annual Reports;Area;Basic Science;cancer health disparity;cancer type;career;Clinical;Collaborations;Colorectal Cancer;community advisory board;design;Development;Disabled Persons;Discipline;Disparity;Educational workshop;Eligibility Determination;eligible participant;Enrollment;Faculty Recruitment;Fostering;Funding;Goals;Grant;Health;Hispanic Populations;Home;Individual;Institution;interest;Leadership;leadership development;Malignant Neoplasms;Medical center;member;Mentors;Mentorship;mid-career faculty;multidisciplinary;NCI-Designated Cancer Center;next generation;novel;Participant;Patients;Persons;Population Sciences;Process;programs;recruit;Redwood;Request for Applications;Research;Research Personnel;Research Project Grants;Research Support;Resource Development;Resources;Review Committee;Scientist;Senior Scientist;Site;Structure;Teacher Professional Development;translational research program;tribal health;Underrepresented Minority;virtual;Woman;Writing

PROJECT_TITLE: Career Enhancement Program


ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: OVARIAN CANCER SPORE: NARRATIVE This SPORE is dedicated to improving overall clinical outcomes in women who suffer from ovarian cancer, which affects approximately 23,000 women in the United States by delivering new approaches to ovarian cancer detection, prevention, and treatment. Over the planned 5 years of funding, each of these new approaches, as monitored using aggressive milestones/timelines, should move measurably closer to clinical application and benefit.

PI_NAMEs: DRAPKIN, RONNY I;SHIH, IE-MING  (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: accurate diagnosis;Address;Adjuvant Therapy;advanced disease;Affect;anti-cancer research;Anxiety;ARID1A gene;base;biobank;Biological Markers;Biostatistics Core;brca gene;Cancer Biology;cancer diagnosis;Cancer Etiology;Cancer Patient;cancer therapy;Carboplatin;Carcinoma;career;CCNE1 gene;Clear Cell;Clinical;clinical application;Clinical Data;clinical efficacy;Clinical Management;Collaborations;collaborative environment;Combined Modality Therapy;Communication;Complex;Data;Death Rate;Dedications;Detection;Developed Countries;Development;Diagnosis;Disease;Disease remission;DNA Damage;DNA Repair;DNA replication fork;drug resistance development;Early Diagnosis;Early treatment;effective therapy;Ensure;Five-Year Plans;Foundations;Funding;Future;Genetic Predisposition to Disease;Genomics;Germ Lines;Goals;Histologic;human capital;Human papillomavirus 16 E1 protein;improved;Incidence;inhibitor;innovation;Institution;Knowledge;Laboratories;Learning;Lesion;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Measurable;Microscopic;Molecular;Molecular Genetics;Monitor;Morbidity - disease rate;mortality;mutant;Mutate;Mutation;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Ovarian Carcinoma;Ovarian Serous Adenocarcinoma;Ovary;overexpression;Paclitaxel;Pathologic;Pathology;Pathway interactions;Patient advocacy;Patients;Pennsylvania;Perioperative Care;phase II trial;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Predisposition;Prevention;programs;Progress Review Group;prophylactic;Proteins;Proteomics;Recurrence;Recurrent disease;replication stress;Reproduction spores;Research;Research Personnel;Research Project Grants;Resistance;Resources;response;Risk Marker;Sampling;Scientific Advances and Accomplishments;Scientist;Screening for Ovarian Cancer;Serous;success;Surgical Management;Technology;technology development;temozolomide;Testing;timeline;Tissues;tool;Translating;Translational Research;Translations;Treatment outcome;Tumor Biology;Uncertainty;United States;Universities;Woman;women's diagnosis;women's outcomes

PROJECT_TITLE: SPORE in Ovarian Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-H (M1)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: ADMINISTRATIVE CORE: NARRATIVE We propose this SPORE to study translational ovarian cancer research, and the Administrative Core provides coordination and facilitation of efforts to collectively bring new molecular diagnostics and novel therapeutic approaches to women with this devastating disease.

PI_NAMEs: SHIH, IE-MING  (contact)

PROJECT_TERMS: Advisory Committees;Agreement;Annual Reports;anti-cancer research;Area;benefit sharing;biobank;Biomedical Research;Biostatistics Core;Cancer Center;career;Clinical;Clinical Research;Collaborations;Communication;Communities;Consultations;Data;Development;Disease;Ensure;Evaluation;experience;Freedom;functional improvement;Funding;Goals;Grant;Human Resources;human subject protection;Human Subject Research;Individual;Industrialization;Institution;Intellectual Property;Leadership;Malignant neoplasm of ovary;meetings;minority investigator;Minority Recruitment;molecular diagnostics;Monitor;National Cancer Institute;NCI Center for Cancer Research;novel therapeutic intervention;Office of Administrative Management;operation;Output;Pathology;Patient advocacy;Pennsylvania;Policies;Preparation;programs;Property Rights;Publications;quality assurance;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk;Safety;Science;Services;Site;skills;success;Technology Transfer;translational scientist;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Administrative Core