NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Immunization;Infectious Diseases;Malaria;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: Phnom Penh

ORG_COUNTRY: CAMBODIA

ORG_FIPS: CB

ORG_NAME: INSTITUT PASTEUR DU CAMBODGE

PHR: This proposal aims at understanding the host immune and genetic factors as well as parasite characteristics that are associated with protection from clinical Plasmodium vivax malaria. Our objectives are to elucidate the mechanisms driving the development of broadly inhibiting anti-Plasmodium vivax antibodies, to identify host and parasite genetic factors associated to protection and to uncover immune pathways of protection and novel potential antigenic targets. Accomplishment of these goals will be reached by leveraging a longitudinal Plasmodium vivax patient cohort displaying contrasted clinical outcome of infection, in combination with state- of-the art technologies on site and our ability to perform short-term cultures of Plasmodium vivax, and will provide invaluable information to design evidence-based intervention strategies for the elimination of this human malaria parasite.

PI_NAMEs: CANTAERT, TINEKE ;POPOVICI, JEAN  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: adaptive immune response;Alleles;Antibodies;Antigens;Area;Automobile Driving;B-Cell Antigen Receptor;B-cell receptor repertoire sequencing;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Binding Proteins;Biological Assay;Blood;Blood specimen;Cambodia;CD4 Positive T Lymphocytes;Cell Culture Techniques;Cells;Characteristics;Chronic;Clinical;cohort;Data;design;Development;Enabling Factors;Erythrocytes;Evidence based intervention;Flow Cytometry;Future;Gene Expression Profile;Genes;Genetic;Genetic Drift;Genetic Polymorphism;Genome;Genomics;Genotype;Globin;Goals;Human;human genome sequencing;Immune;Immune response;Immunity;Immunologic Factors;Immunologics;Immunophenotyping;In Vitro;in vitro testing;Individual;individual response;Infection;inhibiting antibody;Intervention;Invaded;Length;Leukocytes;Ligands;Longitudinal cohort;Malaria;Mediating;Membrane Proteins;Memory B-Lymphocyte;Messenger RNA;Minority;Minority Groups;Monoclonal Antibodies;monoclonal antibody production;monocyte;morphogens;novel;novel vaccines;Outcome;Parasites;Participant;Patients;Peptides;Phenotype;Plasmodium vivax;polyadenylated messenger RNA;Population;Production;protective pathway;Protein Isoforms;Proteins;receptor;resilience;Reticulocytes;Sampling;single-cell RNA sequencing;Site;Sorting;Surface;symptom treatment;T-Lymphocyte;Technology;Testing;transcriptome sequencing;vaccine candidate;vaccine development;Vaccines;Vivax Malaria;whole genome

PROJECT_TITLE: Comprehensive characterization of the genetic factors and the host immune response associated to protection from clinical Plasmodium vivax malaria

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Patient Safety;Prevention;Wound Healing and Care

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The Diabetic Foot Consortium aims to validate biomarkers that promote healing and prevent recurrence of diabetic foot ulcers and leverage their growing database of patient, wound, therapies and biomarker characteristics to advance standard care. Proper design of biomarker validation studies and analyses using advanced machine learning methods are critical to accomplish these goals. With more than 23 years of experience, the University of Michigan data coordinating center will continue to apply cutting-edge statistical and operational methods to these studies, maximizing the clinical impact of the consortium in this complex and challenging therapeutic area.

PI_NAMEs: SPINO, CATHERINE A (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Accounting;Adherence;Adverse event;Ancillary Study;Architecture;Area;bench to bedside;biobank;Bioinformatics;Biological Markers;biomarker discovery;biomarker validation;Budgets;Caring;Characteristics;Chronic Disease;Clinical;Clinical Research;Collaborations;Collection;Communication;comorbidity;Complex;Complications of Diabetes Mellitus;Contracts;Data;Data Analyses;Data Analytics;Data Collection;Data Coordinating Center;data integration;data management;Databases;design;Diabetes Mellitus;Diabetic Foot;Diabetic Foot Ulcer;Diagnostic;Ensure;Esapent;experience;FDA approved;Foot Ulcer;Foundations;Future;Goals;healing;Health;Heterogeneity;improved;Infrastructure;Institutional Review Boards;Knowledge;knowledge base;Laboratories;Leadership;Learning;machine learning method;Measurement;meetings;Methods;Michigan;Modeling;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Observational Study;Online Systems;operation;Outcome;patient subsets;Patient-Focused Outcomes;Patients;payment;Physicians;predictive marker;prevent;Process;Protocols documentation;Qualifying;Recurrence;Reporting;repository;Reproducibility;Research Personnel;safety outcomes;safety study;Sampling Biases;Science;Scientist;Scoring Method;Secure;Services;Site;social health determinants;standard care;standard of care;Statistical Methods;study population;Subgroup;success;System;Techniques;Therapeutic;Time;tool;Translations;treatment adherence;Universities;validation studies;web site;webinar;wound

PROJECT_TITLE: University of Michigan Data Coordinating Center for the Diabetic Foot Consortium


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE  Recent cancer treatment strategies stimulate patient's own immune system to mount a strong immune response against otherwise immuno-evasive cancer cells, with promising results in various solid tumors, but this approach is inefficient for treatment of liver cancer. Since freezing tumors by cryoablation triggers anti-tumor immune responses, we posit that cryoablation may enhance treatment effects in liver cancer for personalized cancer therapy. We will use a mouse model of liver cancer that mimics the important stages of liver injury seen in humans, and establish a novel combination of immune cell targeting and metabolic imaging to detect the cryoablation-induced modulation of the immuno-metabolic interplay in liver cancer.

PI_NAMEs: COMAN, DANIEL  (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Acidity;Acidosis;Address;aerobic glycolysis;Animal Model;anti-PD-1;anti-tumor immune response;Antibodies;Antigens;antitumor effect;Biological Markers;Biosensor;Brain Neoplasms;cancer cell;Cancer Etiology;cancer immunotherapy;cancer therapy;Cell Death;Cells;cellular imaging;Cessation of life;Chemoembolization;Chronic;chronic liver disease;Cirrhosis;Clinical;clinical imaging;Cryosurgery;CTLA4 gene;curative treatments;cytotoxic;density;Development;Diagnosis;Distal;effector T cell;exhaustion;extracellular;Fibrosis;Freezing;Functional disorder;Future;Glucose;Goals;Growth;Helper-Inducer T-Lymphocyte;Histopathology;Human;Image;Imaging Device;Imaging Techniques;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immunization;immunogenic;immunogenicity;Immunologics;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Situ;in vivo;Inflammation;innovation;instrument;interstitial;Intervention;Investigation;Knock-out;Knockout Mice;Lesion;Liver;liver cancer model;liver inflammation;liver injury;Liver neoplasms;Localized Disease;Macrophage;Magnetic Resonance;Magnetic Resonance Imaging;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Melanoma;metabolic imaging;Methods;Monitor;mouse model;Multidrug Resistance Gene;multiple drug use;Mus;neoplastic cell;non-invasive imaging;novel;Oryctolagus cuniculus;Patients;permissiveness;personalized cancer therapy;personalized medicine;Phagocytes;Phenotype;pre-clinical;Primary carcinoma of the liver cells;public health relevance;Radiofrequency Interstitial Ablation;recruit;resistance mechanism;Resolution;response;Solid Neoplasm;success;Systemic Therapy;T-Cell Activation;T-Lymphocyte;targeted imaging;therapy design;tissue injury;Tissues;treatment effect;Treatment Protocols;treatment strategy;tumor;Tumor Antigens;tumor metabolism;tumor microenvironment;tumor progression;Tumor Promotion;tumor-immune system interactions;Tumor-infiltrating immune cells;Visualization;Warburg Effect

PROJECT_TITLE: Modulating the immuno-metabolic interplay in liver cancer with cryoablation


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Neurosciences

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Project Narrative In the past several years, important progress has been made in identifying genes implicated in neurodevelopmental disorders. It is now recognized that KCNQ2 loss and gain of function mutations lead to developmental epileptic encephalopathy that might also include respiratory dysfunction and severe central hypoventilation syndrome. Therefore, the goal of this application is to understand the essential role of KCNQ2 in control of breathing that may explain both the origins and developmental progression of symptoms, as well as to propose strategies for effective therapeutic interventions.

PI_NAMEs: MULKEY, DANIEL K (contact);TZINGOUNIS, ANASTASIOS

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Affect;Animals;autism spectrum disorder;Binding;Brain;Breathing;Carbon Dioxide;Cell Nucleus;Chemoreceptors;Chronic;cofactor;Coupled;Development;developmental epileptic encephalopathy;Electrophysiology (science);epileptic encephalopathies;Foundations;gain of function;gain of function mutation;Genes;genetic manipulation;Goals;Hydrolysis;Hypoventilation;improved;knock-down;Lead;Link;loss of function;Mediating;Modeling;Mus;Mutation;Myoclonus;myoinositol;neonatal brain;neural;Neurodevelopmental Disorder;Neurons;Neurotransmitters;novel;parent grant;Patients;pharmacologic;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Potassium Channel;Production;Property;receptor;Recurrence;Reflex action;Regulation;Research;Respiration Disorders;respiratory;Respiratory Center;response;Role;Signal Transduction;Slice;symporter;Symptoms;Synapses;Syndrome;Testing;Therapeutic Intervention;therapeutic target;therapeutically effective;Tissues;Variant;Viral;Work

PROJECT_TITLE: Role of KCNQ2 Channels in Control of Breathing

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Contraception/Reproduction;Endometriosis;Nanotechnology;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative Endometriosis remains an enigmatic disease whose basic biology still eludes us. Animal models, in which the induced disease is reflective of the human condition, offers the best hope for understanding the early events associated with the pathophysiology of this disease and more importantly the basic knowledge as to how inflammation, a hallmark of the disease, promotes lesion development. Studies proposed in this application focus on how inflammatory cytokines and the NOTCH signaling pathway contribute to the development of endometriosis and their potential as therapeutic targets.

PI_NAMEs: FAZLEABAS, ASGERALLY T. (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: 3-Dimensional;Adhesions;Affect;Affinity;Age;angiogenesis;Animal Model;Binding;Biology;Cell Communication;Cell Culture Techniques;Cell Proliferation;Cell Survival;Cells;Chronic;Clinical;Coupled;cytokine;Development;Diagnosis;Disease;Disease Progression;Dominant-Negative Mutation;Endometrial;endometriosis;Engineering;Environment;Ephrin B Receptor;Estrogens;Etiology;Event;extracellular;Family;Fluorescence;Functional disorder;gain of function;gene function;Gynecologic;Human;human tissue;immune function;immunoregulation;Implant;In Vitro;in vivo;Infertility;Inflammation;Inflammatory;innovation;Interleukin-6;Invaded;Knowledge;Lesion;loss of function;Malignant Neoplasms;MAP Kinase Gene;Membrane;migration;Modeling;Molecular;mouse model;nanolabel;nanoparticle;notch protein;Notch Signaling Pathway;NOTCH1 gene;novel;novel therapeutic intervention;Onset of illness;Organoids;Outcome Study;overexpression;p38 Mitogen Activated Protein Kinase;Papio;Pathologic;Pathologic Processes;Pathway interactions;Pelvic Pain;Pelvis;Peptides;Peritoneal;Peritoneum;Phosphorylation;prevent;Proliferating;promoter;Proteins;receptor;Regulation;reproductive;Signal Pathway;Signal Transduction;Symptoms;targeted delivery;targeted treatment;TCF3 gene;Therapeutic;therapeutic target;Tissues;transcription factor;Translating;Up-Regulation;Uterus;Variant;Woman;Women's study

PROJECT_TITLE: Regulation of Endometriotic Lesion Development by NOTCH1

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Bioengineering;Cancer;Kidney Disease;Nanotechnology;Orphan Drug;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: One of the most successful chemotherapy drugs is cisplatin, also known as penicillin for cancer. However, patients many times couldn't stay in the effective anti-cancer treatment from cisplatin, because it causes injury to kidneys. With the success of this study, we could provide our patient with non-invasive early detection and mitigate cisplatin induced acute kidney injury for them to stay on their effective anti-cancer treatment.

PI_NAMEs: PAN, HUA  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;adaptive immune response;Address;Adverse effects;Affect;Aftercare;Amifostine;Animals;anti-cancer;anti-cancer treatment;Antineoplastic Agents;Apoptosis;Autophagocytosis;base;Biodistribution;Blood Vessels;Brain;Cancer Patient;Cancer Survivor;cancer therapy;cell injury;Cells;chemotherapy;Chemotherapy-Oncologic Procedure;childhood cancer survivor;Chronic;Chronic Kidney Failure;Cisplatin;clinical translation;Clinical Trials;Cytoplasm;Disease;Dose;Drug Interactions;Drug Kinetics;Drug or chemical Tissue Distribution;Early Diagnosis;early phase clinical trial;effective therapy;efficacy evaluation;Endothelium;Evaluation;Event;Exhibits;Failure;Fluorocarbons;Follow-Up Studies;FRAP1 gene;Hydration status;hypoperfusion;Hypoxia;imaging modality;Impairment;improved;improved outcome;In Vitro;in vivo;Incidence;Individual;Inflammation;injured;Injury;Injury to Kidney;Intervention;Kidney;kidney vascular structure;Magnesium;Magnetic Resonance Imaging;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Medical;Molecular;Morbidity - disease rate;mortality;mortality risk;Mus;nanoparticle;nanoparticle delivery;nephrotoxicity;Organ;ovarian neoplasm;Oxidative Stress;Patients;Penicillins;Pharmaceutical Preparations;Pharmacodynamics;Platinum;Population;preclinical study;preservation;prevent;Prevention;Prognosis;Quality of life;quantitative imaging;Regimen;Renal function;Reperfusion Injury;Risk;Safety;Serum;side effect;Signal Pathway;Signal Transduction;Sirolimus;statistics;success;Survival Rate;targeted agent;Testing;Therapeutic;therapeutic evaluation;Toxic effect;Treatment Efficacy;Tubular formation;tumor;tumor growth;United States;uptake;vascular injury;Warm Ischemia;wasting

PROJECT_TITLE: Mitigate cisplatin induced acute kidney injury through preservation of vasculature and proximal tubule

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative Black women have higher breast cancer mortality, and different prevalence of key DNA repair pathway mutations, notably p53. These DNA repair pathways may interact with other mechanisms of treatment resistance, including immune responses. This project will elucidate the relationship between p53, DNA repair mechanisms, and immune response and evaluate the implications of these pathways for mortality disparities.

PI_NAMEs: HOADLEY, KATHERINE A.;TROESTER, MELISSA A. (contact)

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: African American;African American population;Age;Base Excision Repairs;Biological;black patient;Black race;black women;BRCA1 gene;Breast Cancer Patient;Cancer Etiology;Chemoresistance;chemotherapy;Clinical;cohort;Complex;Data;Death Rate;Defect;Development;Disparity;DNA;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA Sequence Alteration;DNA sequencing;Equilibrium;Expression Profiling;Formalin;Frequencies;Gene Expression;Genes;Genetic;Genetic Recombination;Genetic Transcription;genetic variant;Genome Stability;genome wide association study;genome-wide;Genomic Instability;Germ Lines;Germ-Line Mutation;Goals;health care availability;Health Services Accessibility;homologous recombination;Human;Immune;immune activation;Immune response;Immunologic Markers;Immunology procedure;improved;Investigation;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Methods;Mismatch Repair;mortality;mortality disparity;mutant;Mutate;Mutation;mutational status;Nonhomologous DNA End Joining;novel;novel marker;Nucleotide Excision Repair;Obesity;Paraffin Embedding;Pathologic;Pathway interactions;Patients;Pattern;Phenotype;pleiotropism;population based;Population Study;precision medicine;predictive marker;Prevalence;Process;prognosis biomarker;Prognostic Marker;protein biomarkers;protein profiling;Proteins;public health intervention;Race;racial difference;repaired;Reproductive History;Research;Resources;response;RNA;Role;Sampling;Source;Specimen;survivorship;therapy resistant;Tissues;TP53 gene;treatment response;tumor;Tumor Biology;tumor progression;Variant;White Women;Woman

PROJECT_TITLE: P53, DNA Repair Imbalance, and Immune Response in Breast Cancer Mortality Disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Heart failure is a growing medical problem for which current medical therapies offer no cure. This proposal will uncover a novel mechanism of regulation of pathologic cardiac remodeling through identifying how the synthesis of specific maladaptive proteins is regulated during cardiac stress. The achievement of the proposed aims should open exciting new therapeutic avenues.

PI_NAMEs: ACCORNERO, FEDERICA  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: 3' Untranslated Regions;Achievement;Address;Affect;Binding Proteins;Cardiac;Cardiac Myocytes;Cell Nucleus;Cells;Complex;Economic Burden;effective therapy;Electron Transport;Enzymes;Event;gain of function;Gene Expression;Gene Proteins;genetic manipulation;Health;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;heart metabolism;Homeostasis;Hypertrophy;Incidence;Knowledge;loss of function;Maintenance;Mass Spectrum Analysis;Medical;Messenger RNA;Metabolic;Metabolism;Methylation;Methyltransferase;Mitochondria;mitochondrial metabolism;Mitochondrial Proteins;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;mRNA Translation;Multiprotein Complexes;Mus;Myocardial dysfunction;nanopore;novel;novel therapeutics;Nuclear;Nucleotides;Operative Surgical Procedures;Outcome;Pathologic;Pathway interactions;Phenotype;Play;Post-Transcriptional Regulation;posttranscriptional;pressure;Protein Biosynthesis;protein complex;protein protein interaction;Proteins;Proteome;Regulation;Research;ribosome profiling;Ribosomes;Role;Site;Specificity;Stress;Stretching;System;Testing;therapeutic development;therapeutically effective;Tissues;Transcript;translational impact;Translations;United States;Work

PROJECT_TITLE: Post-transcriptional regulation of cardiac hypertrophy

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ATHENS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Development of male and female sex in vertebrates relies on a conserved set of interactions among a multi- component network of differentiation genes. The key gene that initiates this process in many vertebrates is a copy of the anti-Müllerian hormone on the Y chromosome (Amhy). Understanding how this is properly regulated in vertebrates has important implications for human health, as disruptions in this process can lead to several disorders of sex development, including sex reversal, intersex phenotypes, and gonadal dysgenesis.

PI_NAMEs: WHITE, MICHAEL ANDREW (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Address;Binding;Biological Assay;Biological Models;candidate validation;Cells;comparative;comparative genomics;Data;Development;Differentiated Gene;Embryonic Development;Evolution;Female;Fishes;Gasterosteidae;Gene Expression Regulation;Genes;Genetic;genetic sex determination;Genetic Transcription;genome resource;Goals;gonad development;Gonadal Dysgenesis;Gonadal structure;Health;Human;In Situ Hybridization;Infertility;innovation;insight;Intersex;Knock-out;Link;male;Mammals;member;Modeling;mullerian-inhibiting hormone;Mutation;Nucleic Acid Regulatory Sequences;Ovary;overexpression;paralogous gene;Pattern;Phenotype;Process;Promoter Regions;Regulation;Regulatory Element;Reporter;Research;response;Role;sex;Sex Chromosomes;sex determination;sex development disorder;Sex Differentiation;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Surface;System;Testing;Testis;Time;transcription factor;Transforming Growth Factor beta;Undifferentiated;Vertebrates;Work;Y Chromosome

PROJECT_TITLE: Functional Analysis of the Anti-Müllerian Hormone as a Convergently Acquired Master Sex Determination Gene

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_DEPT: PEDIATRICS

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE  Young children with autism often have long wait times for diagnosis and intervention; this is especially true of children from Latinx families and may prevent these children from getting the earliest possible intervention. The proposed project will adapt and test a comprehensive, on-line, parent-mediated, free intervention (OPT-In- Early Bilingual Latinx Version) for Latinx families in the US; it can be used during these wait times and supplement professional intervention. Results of this study will lead to a large-scale test of this intervention, with the goal of making it freely available to Latinx families and optimizing their children's development.

PI_NAMEs: ZUCKERMAN, KATHARINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: Acceleration;access disparities;Adult;Age;Albania;applied behavior analysis;arm;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic;autistic children;Behavior;bilingualism;Caregivers;Caring;Cellular Phone;Child;Child Behavior;Child Care;Child Development;Child Rearing;Communication;Communities;coping;cost;culturally appropriate intervention;design;Development;Developmental Delay Disorders;Diagnosis;Diagnostic;Disparity;disparity reduction;Early Intervention;Educational Intervention;Educational Materials;Educational process of instructing;empowerment;evidence base;experience;Extended Family;Family;Feedback;follow up assessment;Goals;handheld mobile device;Intervention;intervention program;Knowledge;Language;Latinx;Latinx population;Learning;Life;Linguistics;Low income;low socioeconomic status;Measures;Mediating;Mediator;mHealth;mhealth interventions;National origin;online version;Outcome;Parent-Child Relations;parenting intervention;Parents;pediatrician;peer;personalized intervention;pilot test;Preparation;prevent;primary care provider;primary outcome;programs;prototype;Provider;public health insurance;rate of change;Reporting;reproductive;Research;Resources;rural area;screening;secondary outcome;Self Efficacy;Services;Severities;skills;social communication;social stigma;Socioeconomic Status;Spanish;Spanish/English;Strategic Planning;Stress;stressor;suspected autism;Tablets;Telephone;Testing;Toddler;Training;Translating;Transportation;Underserved Population;United States National Institutes of Health;uptake;usability;Wait Time;Waiting Lists;willingness;Woman;Work

PROJECT_TITLE: Parent Training for Latinx Autistic Toddlers: Development and Preliminary Testing

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Clinical Research;Complementary and Integrative Health;Dietary Supplements;Microbiome;Nutrition;Obesity;Osteoarthritis

ORG_CITY: Aurora

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE This project aims to 1) definitively establish that a pro-inflammatory dysbiotic gut microbiome is causal in the OA of obesity, and 2) demonstrate that correction of this dysbiosis using strategies to expand B. pseudolongum will decelerate the progression of OA in the obese context.

PI_NAMEs: GILL, STEVEN R.;ZUSCIK, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Acceleration;Actinobacteria class;Address;Arthritis;B-Lymphocytes;Bifidobacterium;Blood;Cells;Circulation;Colon;Communication;Communities;comorbidity;cytokine;Data;Deceleration;Degenerative polyarthritis;Development;diet-induced obesity;Dietary Supplementation;Disease;dysbiosis;Epithelium;Experimental Designs;experimental study;Family member;Fiber;gut dysbiosis;gut microbiome;Health;High Fat Diet;Human;Immune;Inflammation;Inflammatory;Intestines;joint destruction;joint loading;Joints;Knee;Knee joint;Link;Macrophage;Mechanics;Medial meniscus structure;Messenger RNA;Metabolic;Metabolism;metabolome;metagenome;metatranscriptome;Methods;microbial;microbiome composition;microbiota;Modeling;mouse model;Movement;multiple omics;multiplex assay;Mus;nano-string;novel therapeutic intervention;Obese Mice;Obesity;Operative Surgical Procedures;Oral;Organoids;palliative;Pathogenicity;Peptococcaceae;prebiotics;Probiotics;Process;resident commensals;Role;Serum;Supplementation;Synovial Membrane;systemic inflammatory response;Taxonomy;Testing;Thinness;Time;Tissue Harvesting;Tissues;transcriptomics;Transgenic Mice;Transplantation;Up-Regulation;Work

PROJECT_TITLE: Studies on gut microbiome-joint connections in arthritis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative  This project will uncover how signaling at cardiomyocyte intracellular membrane microdomains contributes to cardiac hypertrophy and heart failure. Although a number of signaling pathways have established roles in cardiac disease pathogenesis, the topography of hypertrophic signal transduction circuitry within the complex architecture of the adult cardiac myocyte is ill-defined. We will interrogate the functions of protein palmitoylation, a reversible lipid modification, in spatiotemporal regulation of compartmentalized signaling events in cardiomyocytes that may potentially be leveraged for the development of more targeted strategies to treat cardiac disease.

PI_NAMEs: BRODY, MATTHEW JACOB (contact)

PROJECT_TERMS: Acylation;Adult;Age;American;Angiotensin II;Angiotensin Receptor;Architecture;Arrhythmia;Biochemical;Biological;Biosensor;Botulinum Toxins;calmodulin-dependent protein kinase II;Cardiac;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;Cause of Death;cell type;Cessation of life;clinically relevant;Complex;Cysteine;Data;Development;Economic Burden;efficacious treatment;Enzymes;Event;Exhibits;experimental study;Family;Fatty Acids;Fractionation;Functional disorder;Generations;Golgi Apparatus;Growth;Guanosine Triphosphate;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Homeostasis;Human;Hypertrophy;in vivo;inducible Cre;Infusion procedures;Intercalated disc;Intracellular Membranes;Knock-in;Lateral;Lipids;Mediating;Membrane;Membrane Microdomains;Modification;Molecular;Monomeric GTP-Binding Proteins;mortality;mouse model;Mus;Muscle Cells;mutant;Mutation;Myocardial;Myocardium;NADPH Oxidase;novel;overexpression;Oxidation-Reduction;Oxidative Stress;Palmitic Acylation Site;palmitoylation;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;Phosphorylation;Physiological;preservation;Prevalence;Production;protein function;Protein Kinase;Proteins;Proteomics;Public Health;rac1 GTP-Binding Protein;Reactive Oxygen Species;Regulation;Reporting;response;rho;Role;Sarcolemma;Signal Pathway;Signal Transduction;spatiotemporal;Testing;Transgenic Mice;United States

PROJECT_TITLE: Defining the cardiomyocyte microdomain signaling landscape in cardiac hypertrophy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Gene Therapy;Genetics;Human Genome;Rare Diseases

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE Over half a million head-and-neck cancer patients suffering from radiation-induced xerostomia are deprived of therapeutics that restore salivary flow long-term. This proposal seeks to deliver an epigenomic editing therapy approach to provide sustained salivary flow in patients suffering from hyposalivation.

PI_NAMEs: LOMBAERT, ISABELLE M.A. (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Adverse effects;Affect;AQP1 gene;bisulfite sequencing;Capsid;Cell Culture Techniques;Cells;chromatin remodeling;Chronic;Climacteric;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CpG Islands;CRISPR/Cas technology;Cytosine;Data;demethylation;Dental caries;Diagnosis;Disease;DNA;DNA Methylation;DNA Sequence;Dose;drinking water;Epigenetic Process;epigenetic therapy;epigenome editing;Epithelial Cells;Epithelium;Exclusion;Exposure to;expression vector;FDA approved;fitness;Foundations;Gene Expression;Gene Silencing;gene therapy;Gene Transfer;Genes;Gland;Goals;Grant;Guide RNA;Head and Neck Cancer;head and neck cancer patient;histone modification;Human;Immune;Immune Evasion;Immune response;Immunity;In Vitro;in vivo;Inflammatory Response;interest;Mediator;Messenger RNA;Methods;Methylation;Miniature Swine;Nature;next generation;non-viral gene therapy;Non-Viral Vector;Oral cavity;oral infection;Osmosis;overexpression;Pain;palliative;Patients;Phase;Plasmids;pre-clinical;Production;promoter;Promoter Regions;Proteins;Radiation;Radiation Dose Unit;Radiation induced damage;Radiation therapy;regenerative;regenerative therapy;Reporting;RNA;Saliva;Salivary;Salivary Glands;side effect;Speech;success;Symptoms;System;Techniques;Technology;Testing;Therapeutic;therapeutic gene;Time;Tissues;tool;transcriptome sequencing;treatment planning;ultrasound;Viral;Viral Vector;Water;water channel;Water Movements;whole genome;Xerostomia

PROJECT_TITLE: Epigenetic Therapy to Treat Radiation-induced Xerostomia

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Genetics;Human Genome;Pediatric

ORG_CITY: ROCHESTER

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Histones package DNA, and cells fine tune the amount of histones available in the nucleus. This regulation of histone levels is particularly critical for early embryos. Using zebrafish and fruit fly models, this project aims to investigate how and why this regulation occurs.

PI_NAMEs: MURPHY, PATRICK J.;WELTE, MICHAEL ANDREAS (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;Affect;Animals;Binding;Binding Proteins;Biological Models;Biology;blastocyst;C-terminal;Caenorhabditis elegans;Candidate Disease Gene;Cell Nucleus;Cells;Chromatin;Cytoplasm;Data;Development;Developmental Process;DNA Packaging;Down-Regulation;Drosophila genus;Embryo;Embryonic Development;Epigenetic Process;Event;Fatty acid glycerol esters;Fishes;fly;gastrulation;Gene Activation;Gene Expression;Gene Expression Profile;Gene Silencing;Genes;Genetic Transcription;Genome;genome-wide;Genomic approach;Genomics;Goals;Histones;Image;In Situ;Injections;Insecta;Laboratories;Lipids;Measures;Mediating;Modeling;Mus;N-terminal;Nature;Nuclear;Organelles;particle;Pattern;Phase;Play;Population;premature;Process;programs;Proteins;Rana;recruit;Regulation;Reverse Transcriptase Polymerase Chain Reaction;Role;S phase;stem cells;Structure;Testing;Time;Transcript;transcriptome;Up-Regulation;Variant;Vertebrates;Zebrafish;zygote

PROJECT_TITLE: Regulation and function of H2A.Z during the mid-blastula transition

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Orphan Drug;Rare Diseases;Wound Healing and Care

ORG_CITY: PHILADELPHIA

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project narrative: Current therapies for autoimmune disease chronically suppress the immune system, which risks severe infection. DSG3-CAART is the first precision T cell immunotherapy for autoimmune disease to enter clinical trials, which presents a unique opportunity to investigate the immunomodulatory effects of this novel targeted therapeutic approach in humans. The proposed studies will elucidate the cellular and molecular determinants of DSG3-CAART activity and host immune response, using clinical samples collected from subjects enrolled in the DSG3-CAART phase 1 study.

PI_NAMEs: PAYNE, AIMEE S (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Adhesions;Adoptive Transfer;Antibody titer measurement;Antigen Targeting;Area;Autoantibodies;Autoantibody binding;Autoantigens;Autoimmune Diseases;Autoimmunity;Automobile Driving;B lymphoid malignancy;B-Cell Antigen Receptor;B-Lymphocytes;Biological Assay;biomarker identification;Blood Component Removal;Bulla;cancer cell;cancer therapy;CD19 gene;Cell Compartmentation;cell killing;Cell surface;Cell Therapy;Cells;Cellular immunotherapy;cellular targeting;chimeric antigen receptor;chimeric antigen receptor T cells;chronic autoimmune disease;Clinical;Clinical Trials;cohort;Collecting Cell;cytokine;Cytoplasm;Cytotoxic Chemotherapy;cytotoxicity;Data;design;desmoglein III;Disease;Disease remission;Dose;Engineering;Enrollment;Enzyme-Linked Immunosorbent Assay;Epithelium;Evaluation;exhaustion;Experimental Models;experimental study;Extracellular Domain;first-in-human;Flow Cytometry;Gene Expression Profiling;Genetic Engineering;Human;human model;Immune response;Immune system;Immune Tolerance;Immunize;Immunological Models;immunoregulation;Immunotherapy;In Vitro;in vitro Model;in vivo;indexing;Infection;Infusion procedures;Investigational New Drug Application;Link;manufacture;Memory;Memory B-Lymphocyte;Molecular;molecular marker;Molecular Profiling;Mucous Membrane;Mus;new therapeutic target;novel therapeutic intervention;open label;Pathologic;Pathway interactions;Patients;Pemphigus;Pemphigus Vulgaris;peripheral blood;phase 1 study;phase I trial;Phenotype;Plasmablast;Pre-Clinical Model;Proteins;Proteome;Proteomics;receptor;Refractory;response;Risk;Safety;Sampling;Serious Adverse Event;Serology;Serum;Specificity;Splenocyte;Surface;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Therapeutic;Therapy Clinical Trials;transcriptome;transcriptomics;Treatment Efficacy;Xenograft Model

PROJECT_TITLE: Immunomodulatory effects of desmoglein 3 chimeric autoantibody receptor T cells (DSG3-CAART) in mucosal pemphigus vulgaris


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Lung;Prevention;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are consequences of pulmonary or systemic infections that increase the buildup of protein-rich fluid in the lungs. The focus of this project will be to assess the mechanism of a critical residue in transient receptor potential channel 6 (TRPC6) that we have identified as a regulator of endothelial TRPC6 activity and to understand the therapeutic potential of blocking the function of this TRPC6 residue to reinstate lung-fluid balance in animal models of lung injury.

PI_NAMEs: MEHTA, DOLLY  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Adopted;Animal Model;Ankyrin Repeat;antagonist;ATAC-seq;Bacterial Infections;Binding;Binding Sites;Blood Vessels;Cell Physiology;Cells;cellular imaging;ChIP-seq;Chromatin;Coupled;Data;Development;Disease;DNA;Endothelium;Enhancers;Epigenetic Process;epigenome;Fluid Balance;gain of function;Generations;Genes;Genetic Transcription;Homeostasis;Impairment;Induced Mutation;Infection;Inflammatory;Injury;intravital imaging;Ion Channel;Isoleucine;Isomerism;Leucine;Ligand Binding;Liquid substance;Lung;lung imaging;Lung infections;lung injury;lung repair;lung vascular injury;Mediating;Molecular Conformation;molecular modeling;mouse model;multiple omics;Mus;mutant;Mutate;Mutation;Mutation Analysis;Natural regeneration;novel;Nuclear Magnetic Resonance;Outcome;Pathology;Patients;Peptides;Phenotype;Play;Pre-Clinical Model;prevent;programs;Proliferating;promoter;Proteins;Pulmonary Inflammation;receptor;recruit;regenerative;repaired;Resolution;restoration;Role;Signal Transduction;Sorting;Supportive care;Surface;Systemic infection;Testing;Therapeutic;Tissues;trafficking;transcription factor;Transcriptional Activation;Trauma;TRP channel;two-photon;vascular injury;Vascular Permeabilities;Virus Diseases

PROJECT_TITLE: Targeting mechanisms activating ion-channel for preventing acute lung injury


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Diabetes;Digestive Diseases;Liver Disease;Obesity

ORG_CITY: TUCSON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative: The severity of non-alcoholic fatty liver disease is positively associated with hyperinsulinemia and insulin resistance. The hepatic vagal nerve provides a conduit by which the liver can communicate to affect insulin release and insulin sensitivity. We propose 3 Aims focused on our central hypothesis that GABA is a hepatokine that can help explain the how hepatic lipid accumulation alters vagal nerve activity to affect hyperinsulinemia and insulin resistance in obesity.

PI_NAMEs: RENQUIST, BENJAMIN JENNINGS (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: 4-Aminobutyrate aminotransferase;Acute;Affect;afferent nerve;Beta Cell;blood glucose regulation;Cell membrane;Central Nervous System;Ceramides;Chronic;Clinical;Clinical Data;Clinical Trials;Communication;Data;Data Set;diet-induced obesity;Diglycerides;Disease;Dose;Enzymes;Equilibrium;Failure;GABA transporter;gain of function;gamma-Aminobutyric Acid;Glucose;Glucose Clamp;glucose disposal;Glutamate Decarboxylase;glycemic control;Hepatic;Hepatocyte;Human;Hyperinsulinism;improved;In Vitro;in vivo;Incidence;Insulin;Insulin Resistance;insulin sensitivity;knock-down;Knock-out;Link;Lipids;Liver;loss of function;Mediating;Modeling;mRNA Expression;Mus;NADH;Nerve;Neurotransmitters;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;Obesity;overexpression;Oxidoreductase;Pancreas;Play;Preparation;Production;Reaction;Research;Research Personnel;response;reuptake;Role;Sampling;Serum;Severities;Shunt Device;Signal Transduction;Signaling Molecule;Skeletal Muscle;Slice;Succinates;Therapeutic;Thinness;translational impact;translational potential;Validation

PROJECT_TITLE: Role of the hepatic GABA shunt in insulin resistance and hyperinsulinemia

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Lysosomes function as critical nodes for macromolecular recycling, metabolic rewiring, and pro-growth signaling in cells and mechanisms that regulate quality control of the lysosome invariably also impact these broader cellular pathways and processes. Using affinity-based capture of intact lysosomes coupled to mass spectrometry-based proteomics, we have identified the Ferlin family of membrane repair factors as novel lysosome membrane proteins. Our proposal will investigate a novel function for Ferlin proteins in promoting enhanced lysosome function and stress resistance in the context of cancer.

PI_NAMEs: PERERA, RUSHIKA MIRIAM (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: Acceleration;Acute;Affinity;Aging;Architecture;Autophagocytosis;Binding;Biochemical;Biochemistry;Biogenesis;Biological Assay;C-terminal;C2 Domain;Calcium;Catabolism;Cell membrane;Cell Membrane Permeability;Cell Physiology;Cell Proliferation;cell type;Cells;Characteristics;Chemicals;comparative;coping;Coupled;Cytoplasm;Data;Dedications;Defect;Degenerative Disorder;Dependence;detection of nutrient;Digestion;Disease;Disease Progression;Dissection;DYSF gene;Endowment;Ensure;Family;Family member;Fluorescent Probes;Goals;Golgi Apparatus;Growth;Health;Homeostasis;Impairment;In Vitro;in vivo;insight;Lipid Bilayers;lysosome membrane;Lysosomes;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Mechanical Stress;Mediating;member;Membrane;Membrane Proteins;Metabolic;Metabolism;metabolomics;Mitochondria;Morphology;Muscular Dystrophies;mutant;Mutation;Myoblasts;Normal Cell;novel;Nutrient;Organelles;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathogenesis;Pathway interactions;Phospholipids;Phosphotransferases;preservation;Process;programs;Property;Protein Family;Proteins;Proteomics;Quality Control;Reaction;Recycling;repaired;resilience;Resistance;response;Role;Route;seal;Signal Transduction;Skeletal Muscle;Stress;Testing;trafficking;transcription factor;Transmembrane Domain;tumor growth

PROJECT_TITLE: Dissecting new mechanisms of lysosome quality control in health and disease

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE We are in perhaps the most exciting era of cancer research to date, with the ability to cure once deadly cancers through hematopoietic stem cell transplantation; but it is nothing short of tragic for a patient to then die during their immunocompromised state because of a respiratory viral infection that is usually considered trivial in healthy people. This project studies the ability of cross-neutralizing antibodies to protect against four of the main respiratory viruses that cause severe disease in stem cell transplant recipients. This research will reveal how these antibodies work, help predict their success or failure in clinical use, and impact the design and testing of next-generation antibody candidates that can overcome resistance from viral evolution.

PI_NAMEs: BOONYARATANAKORNKIT, JIM  (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: Adult;Animal Model;Animals;anti-cancer research;Antibodies;Antibody Binding Sites;Antibody Therapy;Antigens;B-Lymphocytes;Binding;Biological Availability;Blood;breakthrough infection;Cell Separation;Childhood;Clinical;clinical development;clinical efficacy;Clinical Trials;combat;Communities;Data;Databases;deep sequencing;design;Development;Disease;Dose;Drug Kinetics;efficacy testing;Epitopes;Escape Mutant;Evolution;experience;Failure;fitness;Frequencies;Future;Half-Life;Hamsters;Hematopoietic Stem Cell Transplantation;Histopathology;Human;Human Metapneumovirus;Immune system;Immunity;Immunocompetent;Immunocompromised Host;Immunosuppression;In Vitro;in vivo;Infant;Infection;infection risk;innovation;Intervention;Knowledge;Lavage;Life;Lower Respiratory Tract Infection;Lung;Lung infections;Magnetism;Malignant Neoplasms;Maps;Measures;Methods;Modeling;Modification;Molecular;Monitor;Monoclonal Antibodies;mortality;mutant;Mutation;mutation screening;Nasal Lavage Fluid;neglect;neutralizing antibody;neutralizing monoclonal antibodies;next generation;nonhuman primate;Nose;novel;Para-Influenza Virus Type 1;Para-Influenza Virus Type 3;parainfluenza virus;Passive Immunization;Patients;Persons;pharmacologic;Phase;Positioning Attribute;post-transplant;pre-clinical;preclinical evaluation;prevent;Prevention;prophylactic;Prophylactic treatment;protective efficacy;Research;Resistance;Resources;respiratory;Respiratory syncytial virus;respiratory virus;Risk Reduction;screening;Serum;Site;standard of care;Stem cell transplant;success;Target Populations;Techniques;Testing;Therapeutic;Time;Trachea;Transplant Recipients;Transplantation;Treatment Efficacy;Variant;Viral;Viral Antigens;viral fitness;viral resistance;Viral Respiratory Tract Infection;virtual;Virus;Virus Replication;Work

PROJECT_TITLE: Molecular basis and protective efficacy of cross-neutralizing antibodies against four major respiratory viruses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(82)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative This grant will help elucidate mechanisms of how glycosylation regulates pathways of cancer initiation. Specifically, we will focus on how O-GlcNAcylation regulates tumor-initiation pathways. Additionally, we will test novel agents for their anti-tumor properties thus this proposal may help establish a new therapeutic target for treatment of cancer.

PI_NAMEs: BALL, LAUREN ELIZABETH;REGINATO, MAURICIO J. (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Epithelial Cells;cancer cell;Cancer Control;cancer initiation;Cancer Model;cancer stem cell;cancer therapy;Cell Death;Cell Maintenance;Cell Proliferation;Cells;chemotherapy;conventional therapy;Data;design;detection of nutrient;Disease;Drug resistance;Drug Targeting;endoplasmic reticulum stress;Enzymes;Epithelium;experimental study;Gene Expression Regulation;Glucose;Glutamine;Glycolysis;glycosylation;Goals;Grant;Growth;Hexosamines;In Vitro;in vivo;in vivo Model;inhibitor;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammospheres;Metabolic;Metabolic Pathway;Metabolism;Molecular;Natural regeneration;Neoplasm Metastasis;new therapeutic target;novel;Nuclear;Nutrient;O-GlcNAc transferase;overexpression;Oxygen;Pathway interactions;pharmacologic;Phenotype;Play;pre-clinical;Process;Property;prostate cancer cell;Proteins;Radiation therapy;rapid growth;refractory cancer;Regulation;Relapse;Resistance;Role;self-renewal;sensor;Shunt Device;Signal Transduction;stem cell biomarkers;Stem Cell Factor;stem-like cell;Testing;Therapeutic;therapeutic target;therapeutically effective;Time;tumor;tumor growth;tumor initiation

PROJECT_TITLE: Role of O-GlcNAcome on Breast Cancer Initiating Cells


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE: Although natural killer T (NKT) cells are emerging as critical players in the pulmonary immune system, knowledge about their role in human influenza virus infections remains rudimentary due to a lack of suitable animal models. This proposal will use a highly translational genetically edited pig model to examine the contribution of NKT cells to three important aspects of influenza virus infection: (i) virus susceptibility, (ii) immunity afforded by inactivated and modified live virus vaccines, and (iii) vaccine associated enhanced respiratory disease illness. The objectives will advance our basic understanding of anti-influenza immune responses and provide a foundation for therapeutically targeting NKT cells to mitigate influenza virus infections in humans.

PI_NAMEs: DRIVER, JOHN  (contact);RICHT, JUERGEN A

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: adaptive immunity;Address;Affect;Animal Model;anti-influenza;Antigens;Cell Physiology;Cell Shape;Cells;Cellular Immunity;cross immunity;cytokine;Cytotoxic T-Lymphocytes;Dangerousness;Disease;Drug or chemical Tissue Distribution;Family suidae;flu transmission;Foundations;Frequencies;Funding Opportunities;Gene Modified;Genes;Goals;Hemagglutinin;high risk;Host Defense;Human;human disease;Immune response;Immune system;Immunity;Immunoglobulin G;Immunologic Memory;Immunologics;immunoregulation;improved;Infection;Inflammation;Influenza;Influenza A virus;influenza infection;influenza virus vaccine;influenzavirus;Integration Host Factors;Knock-out;Knockout Mice;Knowledge;Lung;Lung Diseases;Modeling;mouse model;Mus;Natural Immunity;novel;Organ;Peptides;Play;Population;porcine model;Predisposition;Production;Property;Resistance;respiratory;Respiratory Disease;Respiratory Tract Infections;Role;Shapes;swine influenza;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic target;translational model;uptake;Vaccination;vaccine response;vaccine safety;Vaccines;Viral Antigens;viral transmission;Virus;Virus Diseases

PROJECT_TITLE: Genetically modified pigs to model NKT cell immunity to influenza virus  infection

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

PHR: PROJECT NARRATIVE We rigorously evaluate the health impacts of a employer-sponsored sales ban on sugary beverages and brief counseling to support reduced consumption, and how they work together. This multilevel intervention (targeting the food environment and individual employees) offers an efficient, scalable strategy for preventing obesity in millions of American working adults. Our findings will also contribute to scientific knowledge about the role of cravings in triggering sugary beverage intake and how interventions can reduce them.

PI_NAMEs: EPEL, ELISSA S.;SCHMIDT, LAURA A (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Adopted;Adult;Alcohols;American;American diet;Attention;behavior change;Behavior Therapy;Beverages;Blood;Blood specimen;Body mass index;brief intervention;California;Calories;Central obesity;Clinical Trials;Coffee;Consumption;cost;Counseling;craving;Cues;Data;Diabetes Mellitus;dietary;Dietary Assessment;drinking;effectiveness evaluation;Employee;Enrollment;ethnic minority;experience;Exposure to;food environment;Fruit;Health;Health Care Costs;Health Food;Health system;Healthcare Systems;high risk;high risk population;Home;Hospitals;Hour;improved;Incentives;Individual;insulin sensitivity;Intake;Intervention;Investments;Knowledge;Lipids;Liquid substance;Low income;Magic;Mediating;Mediation;Metabolic;Metabolic Diseases;Modeling;Motivation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity prevention;Occupational Status;Outcome;Participant;Pilot Projects;Policies;Prevention;primary outcome;programs;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;remote assessment;remote delivery;Research;Risk;Risk Factors;Role;Sales;Schools;Science;secondary outcome;Self Administration;Serum;Site;soft drink;Source;Sports;sugar;sweetened beverage;synergism;Tea;Testing;therapy design;Tobacco;waist circumference;Work;Workplace

PROJECT_TITLE: Multi-Level Trial of a Workplace Sales Ban of Sugary Beverages and Brief Motivational Counseling Intervention on Adiposity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-T(02)]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE With the advent of spatial transcriptomics, there is now a strong need for computational methods able to deconvolve the underlying biological signals. Here we propose algorithms for systematically and robustly identifying cell-cell interactions through an integration of spatial transcriptomics with matched single-cell RNA- Seq data. Overall this proposal is innovative for its novel algorithms, which are deployed and tested in the male germline and the placenta.

PI_NAMEs: YANAI, ITAI  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Adopted;Algorithms;Atlases;Biological;Biological Assay;Biological Models;Biological Process;biological systems;Catalogs;Cell Communication;Cell Extracts;cell type;Cells;Complex;Computing Methodologies;Data;Data Set;Data Sources;Detection;Dissociation;experience;Generations;Genes;Germ Lines;Glass;Graph;graph theory;Immunofluorescence Immunologic;Individual;innovation;insight;Ligands;Link;Location;male;Maps;Measures;Methods;multimodality;Neighborhoods;novel;Organ;Organism;Pattern;Placenta;Population;receptor;Recurrence;Resolution;response;Signal Transduction;single molecule;single-cell RNA sequencing;Slide;spatial integration;Spottings;System;Technology;technology validation;Testing;Time;Tissues;transcriptome;transcriptomics;Validation;Variant

PROJECT_TITLE: Computational approaches for the systematic detection of cell-cell interactions by spatial transcriptomics - Resubmission - 1

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Hematology;Neurosciences;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease;Stroke

PHR: PROJECT NARRATIVE Children with sickle cell anemia suffer from progressive cognitive decline as they age, yet the pathophysiology of this cognitive dysfunction is poorly understood, which poses a barrier to the development of predictive biomarkers. Through longitudinal cognitive testing and brain MRIs evaluating metabolic stress, structural connectivity and functional connectivity, we aim to determine the mechanism of cognitive dysfunction in children with SCA and develop neuroimaging biomarkers predictive of both acutely reversible injury and long- term cognitive trajectories. The impact of this proposal lies in the potential improvement of risk stratification algorithms clinically used to guide patient care, and the development of biomarkers that can assess treatment effect of new interventions, ultimately improving clinical outcomes in this vulnerable population.

PI_NAMEs: FIELDS, MELANIE ERIN (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acute;Age;age effect;Algorithms;Anatomy;Attenuated;Biological Markers;biomarker development;biomarker validation;Brain;Brain Injuries;brain magnetic resonance imaging;Brain region;Cerebrum;Child;Childhood;Chronic;Clinical;Cognitive;cognitive function;cognitive testing;cohort;comparison control;connectome;Data;Development;efficacy evaluation;Erythrocyte Transfusion;Evaluation;Executive Dysfunction;executive function;experience;Exposure to;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Future;Goals;Impaired cognition;improved;improved outcome;Infarction;Injury;innovation;insight;Intervention;Ischemia;Lifelong disability;Link;Magnetic Resonance Imaging;Measures;Mediating;Mentored Patient-Oriented Research Career Development Award;Metabolic;Metabolic stress;Metabolism;MRI Scans;Nervous System Trauma;neuroimaging;neuroimaging marker;novel;Outcome;Oxygen;Participant;Patient Care;patient population;Patients;predictive marker;prevent;Primary Prevention;prospective;recruit;Rest;risk prediction model;risk stratification;Screening procedure;Sickle Cell Anemia;Stroke;stroke risk;Structure;Techniques;Testing;Time;Transcranial Doppler Ultrasonography;Transfusion;treatment effect;Treatment Efficacy;Vulnerable Populations;white matter

PROJECT_TITLE: The Impact of Cerebral Metabolic Stress on the Development of the Structural and Functional Connectome in Pediatric Sickle Cell Anemia

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Diabetes;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative/Public Health Statement These exploratory studies are relevant to public health. First, this project will provide proof-of-concept evidence that it is possible to generate beta cells via direct programming of stem cells for the treatment of type 1 diabetes. Secondly, the engineered universal donor stem cell-derived beta cells can be transplanted into many patients without immune rejections, which could substantially reduce cell-based therapy cost.

PI_NAMEs: LIAN, XIAOJUN  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Acceleration;activin A;Affect;aptamer;autoimmune pathogenesis;Beta Cell;Biological Assay;Blood Glucose;C-Peptide;Cell Differentiation process;Cell Line;Cell Therapy;Cell Transplantation;Cells;Cellular biology;Chemicals;Clone Cells;Cloning;Complementary DNA;cost;Coupled;CRISPR-mediated transcriptional activation;Cytolysis;Defect;delivery vehicle;design;Development;Diabetes Mellitus;diabetic;differentiation protocol;directed differentiation;donor stem cell;Electron Microscope;endocrine pancreas development;Engineering;Exhibits;experimental study;functional restoration;Gene Expression;Generations;Genes;genomic locus;Genomics;Glucose;Goals;Growth Factor;Guide RNA;Homologous Transplantation;HSF1;human induced pluripotent stem cells;humanized mouse;Image;Immune;Immune Evasion;Immunologic Tests;In Vitro;in vivo;Individual;innovation;insulin secretion;Insulin-Dependent Diabetes Mellitus;Islet Cell;Measures;Mediating;Mediator of activation protein;Metabolic Diseases;mouse model;Mus;Mutagenesis;Natural Killer Cells;novel;novel therapeutics;oligodendrocyte progenitor;overexpression;p65;Pancreas;Patients;Persons;Population;programs;Property;Public Health;Research Personnel;RNA;screening;single-cell RNA sequencing;Speed;stem cells;Structure of beta Cell of islet;System;T-Lymphocyte;Technology;Testing;Therapeutic;Time;Time Study;transcription factor;Transcription Initiation Site;Transfection;Transfer RNA;Transplantation;United States;vector;Viral Vector

PROJECT_TITLE: ModRNA-based Direct Programming of Universal Donor hiPSCs into Immune Evasive Beta Cells

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Genetics;Infectious Diseases;Rare Diseases;Stomach Cancer

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project narrative A bacterium known as Helicobacter pylori colonizes the stomach in about half of all humans; most do not develop any symptoms related to this infection, but some develop stomach cancer or peptic ulcer disease. Stomach cancer is the third leading cause of cancer-related death worldwide and H. pylori infection is the leading cause of stomach cancer. The long-term goals of this research are to understand the molecular mechanisms by which H. pylori infection can lead to disease, and to understand the basis for variation in clinical outcomes among H. pylori-infected persons.

PI_NAMEs: COVER, TIMOTHY L (contact);OHI, MELANIE DIANE

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Address;alpha helix;Animal Model;Antibiotic Resistance;Antibiotics;Architecture;Bacteria;base;Biological Assay;Cancer Etiology;carcinogenesis;Carcinogens;Cell Culture Techniques;Cells;Cessation of life;Chromosome Mapping;Chronic;Clarithromycin;Classification;Clinical;Complex;Cryoelectron Microscopy;Disease;DNA;Duodenal Ulcer;Elements;Event;Exhibits;fitness;Funding;Gastric Adenocarcinoma;Gastric lymphoma;Gastric mucosa;Gastric ulcer;Gene Expression;Genes;genetic manipulation;Genetic Techniques;Goals;Gram-Negative Bacteria;Helicobacter Infections;Helicobacter pylori;Helicobacter pylori induced gastric cancer;Homologous Gene;Human;improved;in vivo;Incidence;Individual;Infection;Knowledge;Life;Link;Malignant - descriptor;malignant stomach neoplasm;Maps;Membrane;Methods;Microbe;Modeling;Molecular;Mucositis;mutant;N-terminal;Nucleotides;Oncoproteins;Organism;Outcome;particle;Pathogenicity Island;Pathologic;Peptic Ulcer;periplasm;persistent bacteria;Persons;Phenotype;Protein Secretion;Proteins;prototype;recruit;Research;Resistance;Resolution;response;Rhizobium radiobacter;Risk Factors;Role;Shapes;Signal Transduction;Stomach;Stomach Diseases;Structural Models;Structure;Structure-Activity Relationship;Symptoms;System;Testing;Time;Type IV Secretion System Pathway;Variant;Virulence Factors;Work;World Health Organization

PROJECT_TITLE: Type IV Protein Secretion in Helicobacter pylori

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Y(02)M]


NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases

PHR: PROJECT NARRATIVE ASXL1 is an epigenetic regulatory protein that plays an important role in both normal neutrophil development and the biogenesis of myeloproliferative disorders. There is a particularly high frequency of ASXL1 mutations in CSF3R-mutant myeloproliferative disorders, which are characterized by an expansion of mature neutrophils. The goal of this proposal is to uncover the molecular mechanism by which ASXL1 contributes to both normal and abnormal neutrophil production.

PI_NAMEs: MAXSON, JULIA E (contact)

PROJECT_TERMS: Abnormal Neutrophil;Acceleration;Behavior;Biochemical;Biogenesis;Biology;Bone Marrow;Cells;Complex;Data;Defect;design;Development;Disease;Disease Progression;Dysmyelopoietic Syndromes;Elements;Epigenetic Process;Failure;Frequencies;Functional disorder;Gene Activation;Gene Expression;genetic regulatory protein;Genetic Transcription;Goals;granulocyte;Granulocyte Colony-Stimulating Factor Receptors;Granulopoiesis;Hematopoiesis;High Prevalence;Histones;Impairment;improved;Intervention;Knock-in Mouse;Knockout Mice;Molecular;mutant;mutant mouse model;Mutate;Mutation;Myelodysplastic/Myeloproliferative Disease;Myelogenous;Myeloid Cells;Myeloproliferative disease;neutrophil;novel;Outcome;Patient-Focused Outcomes;Patients;peripheral blood;Phenotype;Play;Process;Production;Prognosis;prognostic significance;programs;promoter;Recurrence;Regulation;Research;RNA Polymerase II;Role;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;stem cell population;Study models;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapy resistant;Transcription Initiation;transcriptomics;Wild Type Mouse

PROJECT_TITLE: Role of ASXL1 in normal and abnormal granulopoiesis.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


NIH_SPENDING_CATS: Aging;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: NARRATIVE While fragility fractures are costly to individuals and healthcare systems, and while highly effective methods exist for preventing fragility fractures, there are currently no risk prediction models that reliably identify persons with HIV (PWH) at greatest risk for fracture. Leveraging an outstanding team of collaborators and research platforms, we will develop, validate and disseminate a Fracture Risk Assessment Calculator that incorporates modifiable HIV-relevant risk factors (FRAC-HIV) to calculate the probability of a fracture among PWH within one year. Our findings will lay the foundation for future intervention trials that will incorporate FRAC-HIV into clinical care algorithms to prevent fractures among PWH.

PI_NAMEs: HSIEH, EVELYN  (contact);WOMACK, JULIE A

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Admission activity;Adoption;Age;aged;Aging;Alcohol abuse;Algorithms;antiretroviral therapy;Assessment tool;Benzodiazepines;Body mass index;Bone Density;Boston;Calibration;care providers;Caring;Cessation of life;Clinical;clinical care;clinical decision-making;clinical practice;clinical risk;cohort;Cohort Studies;comorbidity;cost;Data;Data Set;demographics;Development;Discrimination;Dual-Energy X-Ray Absorptiometry;Economics;electronic data;Electronic Health Record;electronic structure;Europe;Exhibits;experience;falls;Foundations;Fracture;fracture risk;fragility fracture;frailty;Future;General Population;Glucocorticoids;Goals;Healthcare Systems;Hepatitis B Virus;Hepatitis C virus;high risk population;HIV;hospitalization rates;improved;Individual;informatics tool;insight;Intervention;Intervention Trial;Life;Long term physical disability;low and middle-income countries;Measures;Medical center;Methodology;Methods;middle age;Modeling;modifiable risk;multiple chronic conditions;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;North America;novel;Nursing Homes;Online Systems;Opioid;Osteoporosis;Persons;Pharmaceutical Preparations;Physiological;Polypharmacy;poor health outcome;predictive modeling;predictive tools;prevent;Prevention;Probability;Productivity;Proton Pump Inhibitors;Provider;Qualitative Methods;Race;Research;Rheumatoid Arthritis;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;risk stratification;Role;Scanning;Screening procedure;sex;Smoking;social;Social isolation;statistics;Subgroup;Substance Use Disorder;Time;tool;Treatment Side Effects;United States;usability;user-friendly;Validation;Veterans;Work

PROJECT_TITLE: Development and Validation of a Novel and HIV-Relevant Prediction Model for Fracture

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Bioengineering;Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Lung

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE A major hurdle in the advancement of therapies that alter the progression of chronic obstructive pulmonary disease is our inability to precisely phenotype individuals with variable disease trajectories. Existing pharmacotherapies fail to impact the rate of FEV1 decline, and the mechanisms that underlie distinct trajectories of disease progression are not well understood. The proposed project will use a combination of clinical and computed tomography data to determine the structural mechanisms underlying disease progression in COPD and establish novel imaging biomarkers to identify individuals at high risk for disease progression.

PI_NAMEs: BHATT, SURYA P. (contact);NAKHMANI, ARIE

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: 3-Dimensional;Adult;Affect;airway obstruction;airway remodeling;Alveolar;alveolar destruction;Anatomy;Area;Attenuated;Cause of Death;Chronic Obstructive Pulmonary Disease;Clinical;clinical predictors;cohort;Complex;Consumption;Cross-Sectional Studies;Data;Development;Diameter;Dimensions;Disease;Disease Progression;Enrollment;Euclidean Space;follow-up;Fractals;genetic epidemiology;Growth;Heterogeneity;high risk;Image;imaging biomarker;indexing;Individual;Inflammation;inflammatory lung disease;insight;Lung;Measures;Mechanics;Modeling;mortality;mouse model;novel;Outcome Measure;Pathway interactions;personalized diagnostics;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Process;Pulmonary Emphysema;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;respiratory morbidity;Scanning;Severities;Shapes;Smoking Status;Spatial Distribution;Stretching;structural determinants;Surrogate Markers;targeted treatment;Testing;Therapeutic;Thick;Time;United States;X-Ray Computed Tomography

PROJECT_TITLE: Structural Determinants of Disease Progression in COPD

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Breast cancer is the most frequent type of cancer that occurs in women (>200,000 cases/year) and accounts for ~40,000 deaths each year in the United States. Triple Negative Breast Cancers (TNBC) are an important clinical subtype because they lack the three known important therapeutic targets used in the breast cancer clinic, namely the Estrogen Receptor, the Progesterone Receptor, and the HER2 protein. In this application, we propose to study the chemotherapy and immunotherapy responsiveness of TNBC and explore the hypothesis that much of the therapy resistance seen is due to a tumor's ability to change from one type of cellular “state” into a more resistant “state”. We hypothesize that we can prevent these state changes using drugs that interfere with DNA structure changes, therefore possibly identifying new therapeutic interventions that might overcome drug resistance in TNBC patients.

PI_NAMEs: PEROU, CHARLES M (contact);ROSEN, JEFFREY MARK

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Adjuvant;Affect;anti-PD-1;Antibodies;ATAC-seq;Autopsy;Breast Cancer Model;Breast Cancer Patient;Cancer Etiology;cancer subtypes;cancer therapy;cancer type;Carboplatin;cell type;Cells;Cessation of life;chemotherapy;Clinic;clinical subtypes;Complex Mixtures;Credentialing;CSF1R gene;Cyclophosphamide;Cytometry;differential expression;Disease;DNA Structure;docetaxel;Drug resistance;Drug usage;efficacy evaluation;epigenetic drug;Epigenetic Process;epigenetic therapy;Epithelial Cells;ERBB2 gene;Estrogen Receptors;Fatty acid glycerol esters;Flow Cytometry;Genes;Genetically Engineered Mouse;genomic profiling;Genomics;Heterogeneity;Histone Deacetylase;Human;Image;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunotherapy;improved;In Vitro;in vivo;in vivo evaluation;Individual;Infiltration;inhibitor;Injections;Label;Liver;Luciferases;Lung;Macrophage;Malignant Breast Neoplasm;Mammary Neoplasms;MERTK gene;Mesenchymal;Metastatic Neoplasm to the Lung;Modeling;molecular subtypes;mRNA sequencing;Mus;Myelogenous;Neoplasm Metastasis;neoplastic cell;novel;novel drug combination;novel therapeutic intervention;Operative Surgical Procedures;Organoids;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phenotype;prevent;primary endpoint;Primary Neoplasm;Progesterone Receptors;programmed cell death ligand 1;programs;Proteins;Regimen;Reporter;Resistance;response;Role;single-cell RNA sequencing;Site;small molecule;Specimen;standard of care;synergism;Tail;Testing;Therapeutic;therapeutic target;triple-negative invasive breast carcinoma;tumor;tumor behavior;tumor initiation;Tumor stage;tumor-immune system interactions;United States;Veins;Visual;Woman;Women's mortality

PROJECT_TITLE: Therapeutic Targeting of Breast Cancer Tumor Initiating Cells

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Genetics;Immunization;Immunotherapy;Infectious Diseases;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE: RELEVANCE Chronic graft-versus-host disease (cGVHD) remains a major obstacle to improving outcomes in hematopoietic cell transplant (HCT) recipients. There is a paucity of biomarkers that could identify patients before the development of the disease. This project will investigate whether certain genes of the immune system and antibodies to a herpesvirus could serve as prognostic markers for cGVHD.

PI_NAMEs: PANDEY, JANARDAN P (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Alleles;Anti-viral Therapy;Antibodies;Antibody Response;antibody-dependent cell cytotoxicity;Antigen-Antibody Complex;Antigens;Autoimmune Diseases;Binding;Biological Markers;Candidate Disease Gene;chronic graft versus host disease;Clinical;Complex;Complication;Cystic Fibrosis;Cytomegalovirus;Development;Disease;Genes;Genetic Markers;Genetic study;Genome;genome wide association study;genome-wide analysis;Genotype;genotyping technology;Heavy-Chain Immunoglobulins;Hematopoietic Stem Cell Transplantation;Herpesviridae;Humoral Immunities;Immune response;Immune system;Immunity;Immunobiology;Immunoglobulin G;Immunoglobulins;Immunologic Surveillance;Immunotherapy;improved;improved outcome;Individual Differences;Infusion procedures;International;Investigation;Life;Measures;Mediating;Meta-Analysis;mouse model;Participant;Patients;Plasma;Play;prevent;prognostic;Prognostic Marker;Proteins;receptor;response;Risk;RL13;Role;Sampling;Scleroderma;Serum;Severities;Single Nucleotide Polymorphism;Specimen;study population;Testing;Transplant Recipients;Variant;Viral;Virus;Virus Diseases

PROJECT_TITLE: IGHG Genes (GM Allotypes) and Anti-CMV (UL70) Antibody Responses as Prognostic Markers for Chronic Graft-Versus-Host-Disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

PHR: Many cortical and subcortical brain regions work together to coordinate social emotional brain states. In this study we propose to build a model from experimental data that explains how these regions work together to generate aggression. We will test this model using established and emerging therapeutics utilized to treat aggression in the clinic, and we will develop new brain stimulation methodologies to regulate aggressive brain states uncovered by our model.

PI_NAMEs: CARLSON, DAVID E;DZIRASA, KAFUI  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Action Potentials;Address;Aggressive behavior;Agonist;Animals;Architecture;Atlases;Behavior;Behavior Control;Behavioral Paradigm;Biological;Blood;Brain;brain cell;Brain region;Catalogs;Cells;cellular targeting;Chemicals;Clinic;Communication;Complex;connectome;Cues;Data;designer receptors exclusively activated by designer drugs;Development;Dopamine;Electrodes;Emotional;emotional behavior;Emotions;Etiology;Experimental Models;experimental study;explainable artificial intelligence;Eye;free behavior;Functional Magnetic Resonance Imaging;Goals;Guanfacine;Habenula;Hour;Human;human subject;Hypothalamic structure;imaging study;Imaging Techniques;Implant;in vivo;Individual;information processing;instrument;Lateral;Learning;Link;Machine Learning;machine learning method;Mammals;Measures;Mediating;Methodology;Methods;millisecond;Modeling;Molecular;Monitor;Motor;multidisciplinary;Mus;Muscle;Music;network models;neural;neuroregulation;Neurosciences;Output;Oxytocin;Peptides;Physiological;Play;Prefrontal Cortex;Process;receptor;Research;Resolution;Rodent;Role;Sensorimotor functions;sensorimotor system;Serotonin;Signal Transduction;Site;Sleep;social;Social Network;spatial integration;spatiotemporal;Stream;System;Techniques;Technology;Testing;Therapeutic;Time;tool;Viral;Vision;Work

PROJECT_TITLE: MULTIREGIONAL ELECTRICAL ENCODING OF SOCIAL AGGRESSION

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative Microglia lose essential homeostatic functions and shift towards a toxic activated phenotype during aging, Alzheimer’s disease, and other neurodegenerative disorders and concurrently have increased calcium dysregulation. The goal of the proposed research is to examine L-type voltage dependent calcium channels as a potential mechanism of microglia calcium dysregulation and subsequent phenotypic changes in microglia during Alzheimer’s disease.

PI_NAMEs: HOPP, SARAH CHRISTINE (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: abeta accumulation;Ablation;age related;age related neurodegeneration;Aging;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;amyloid pathology;antagonist;Antiinflammatory Effect;Autopsy;beta amyloid pathology;Brain;brain cell;Calcium;Cells;Chronic;Clinical;Cognitive deficits;Cre-LoxP;cytokine;Data;differential expression;Excision;experimental study;follow-up;Gene Expression;Generations;Genes;Genetic;genetic approach;Goals;Growth Factor;Histopathology;Homeostasis;Human;Immune;In Vitro;in vivo;in vivo imaging;Incidence;inducible Cre;Intervention;Isradipine;knock-down;L-Type Calcium Channels;Link;Maintenance;Measures;Mediating;Memory impairment;Microglia;migration;Morphology;mouse model;multiphoton imaging;Mus;Neurodegenerative Disorders;neuroinflammation;Neurons;neurotoxic;neurotoxicity;neurotrophic factor;overexpression;Pathologic;Pathology;Phagocytosis;Pharmaceutical Preparations;pharmacologic;Phenotype;prevent;Production;Proliferating;Reactive Oxygen Species;Regulation;Research;response;Rest;risk variant;Rodent Model;Role;Sampling;Senile Plaques;Signal Pathway;single nucleus RNA-sequencing;Small Interfering RNA;spatial memory;Stimulus;Testing;therapeutic development;Training;Transgenic Mice

PROJECT_TITLE: Dysregulated intracellular calcium in microglia during Alzheimer's disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Mental Health;Neurosciences;Pediatric;Precision Medicine;Social Determinants of Health;Violence Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Motor functional neurological disorder (mFND) is a prevalent and disabling neuropsychiatric disorder whereby individuals present with psychogenic (medically-unexplained) motor symptoms driven in part by abnormalities within and across salience and motor control brain networks. This neuroimaging project, with a longitudinal component, aims to use advanced structural and functional brain imaging to comprehensively characterize clinically-meaningful neurobiological subtypes of mFND. The long-term impact of this research is to define the pathophysiology of mFND, identify prognostic biomarkers, and catalyze the development of new biologically- informed treatments.

PI_NAMEs: PEREZ, DAVID LEWIS (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Aftercare;Amygdaloid structure;Anterior;Anxiety Disorders;Applications Grants;Architecture;Biological Markers;biopsychosocial;blood oxygen level dependent;brain control;Brain imaging;Brain scan;care outcomes;Caring;Child Abuse;Childhood;Clinic;Clinical;Cognitive Therapy;Complex;Conversion disorder;Coupling;Data;Development;diagnostic criteria;Diagnostic Specificity;Diagnostics Research;Diffusion Magnetic Resonance Imaging;Disabling;Disease;Disease Marker;disorder subtype;Dorsal;DSM-V;Enrollment;Epidemic;Etiology;Evidence based treatment;Exhibits;follow-up;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;functional MRI scan;Funding;graph theory;gray matter;Headache;Health Care Costs;Healthcare;Height;High Prevalence;imaging properties;imaging study;improved;Individual;Individual Differences;Insula of Reil;interest;Life Experience;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;median forebrain bundle;Medical;Medicine;midbrain central gray substance;Modeling;Moods;morphometry;Motor;motor behavior;motor control;Motor Cortex;motor symptom;MRI Scans;Multimodal Imaging;multimodal neuroimaging;multimodality;National Institute of Mental Health;neglect;Nervous System Disorder;neural;neural circuit;Neurobiology;neuroimaging;Neurologist;neuromechanism;Neuronal Plasticity;neuropsychiatric disorder;neuropsychiatry;Neurosciences;novel therapeutics;Outcome;Outpatients;Patient Participation;patient prognosis;Patients;Performance;Phenotype;physical abuse;Physical therapy;Population;predictive marker;Prevalence;Prognosis;Prognostic Marker;Property;Psychiatry;psychologic;recruit;Rehabilitation therapy;Reporting;Research;response;Rest;Retinal blind spot;Risk Factors;Selection for Treatments;Severities;Sexual abuse;stria terminalis;structural imaging;Symptoms;System;theories;treatment response;Tremor;white matter;Work

PROJECT_TITLE: Defining Neurobiological Subtypes of Motor Functional Neurological Disorder

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Diabetes;Genetics;Obesity

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Type 2 Diabetes (T2D) typically develops in the backdrop of obesity-induced insulin resistance, but manifests clinically as hyperglycemia only with β cell dysfunction. Several T2D therapies increase insulin secretion, but molecular determinants of other aspects of β cell biology affected in T2D – loss of maturity, altered cell-cell and cell-stroma interactions – remain incompletely understood. In this application, we focus on cause and effects of β cell Notch activation, a maladaptive response to obesity that drives β cell dysfunction.

PI_NAMEs: PAJVANI, UTPAL  (contact)

PROJECT_TERMS: Acetylation;Acetyltransferase;Activities of Daily Living;Address;Adult;Affect;Aging;Antibodies;Architecture;Beta Cell;Biological;Cell Differentiation process;cell stroma;Cells;Cellular biology;Chromatin;Clinical;Data;db/db mouse;Decision Making;Defect;Development;diabetes mellitus therapy;direct patient care;Embryo;euglycemia;expectation;feeding;functional adaptation;Functional disorder;gain of function;Gene Expression;Genetic;Genetic Transcription;Glucose;Glucose Intolerance;glucose tolerance;Goals;Heterogeneity;High Fat Diet;Human;Hyperglycemia;Impairment;improved;inhibitor;Insulin;Insulin Resistance;insulin secretion;islet;Islets of Langerhans;knock-down;Knock-out;Knockout Mice;leptin receptor;Ligands;liquid chromatography mass spectrometry;loss of function;Lysine;Mediating;Metabolic Diseases;Methods;Modeling;Molecular;Mus;mutant;Non-Insulin-Dependent Diabetes Mellitus;notch protein;novel;novel therapeutics;Obese Mice;Obesity;Organism;Pancreas;Pathology;Pathway interactions;Patients;Post-Translational Protein Processing;postnatal human;Pregnancy;Protein Family;Proteins;Publishing;receptor;response;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stressor;Testing;Therapeutic;Thinness;Tissues;Transactivation;transcription factor;transcriptome sequencing;Transgenic Organisms;Work

PROJECT_TITLE: Beta cell Notch activity in Type 2 Diabetes

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative The studies described in this proposal would lead to a better mechanistic understanding of the role of interactions between the ventral hippocampus and amygdala in processes associated with behavioral responses to previously experienced threats. Specifically, it has been established previously that PTSD patients exhibit deficits in recall of extinction memory and display increased activation of the amygdala. Thus, explaining behavioral features of extinction at the neuronal network and cellular level, we would shed light on the mechanisms of extinction impairments in human PTSD patients.

PI_NAMEs: BOLSHAKOV, VADIM  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Affect;Amygdaloid structure;Anxiety;Behavior;behavior change;Behavioral;behavioral outcome;behavioral response;Biological Assay;Brain;brain circuitry;Cell Nucleus;Chemosensitization;conditioned fear;Conditioned Stimulus;conditioning;Dependence;Development;Disease;Electrophysiology (science);Equilibrium;Exhibits;experience;Exposure to;Extinction;fear memory;Fright;Functional disorder;Genetic;Hippocampus;Human;Impairment;in vivo;Learning;Link;Mediating;Memory;Modeling;Modification;Mus;Negative Valence;neural;neural circuit;neural network;neuromechanism;Neurons;neurotransmission;optogenetics;Output;Pathologic;Pathway interactions;Patients;Pilot Projects;Play;Post-Traumatic Stress Disorders;Process;Reporting;Research Domain Criteria;response;Retrieval;Role;Signal Transduction;Slice;Stimulus;Stress;Structure;Synapses;Synaptic plasticity;Synaptic Transmission;System;targeted treatment;Techniques;Testing;tool;Training;trait;transmission process;Viral Vector;Whole-Cell Recordings

PROJECT_TITLE: Synaptic and neuronal mechanisms of fear control: the role of hippocampal-amygdalar interactions


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Biomedical Imaging;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Mental Health;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE – PUBLIC HEALTH RELEVANCE Severe neurologic complications (e.g., stroke) of COVID-19, may represent the tip of an iceberg, signaling unrecognized changes in brain structure and function among the more than 90% of patients who experienced only mild COVID-19 or asymptomatic infection with SARS-CoV-2. Unrecognized brain effects of SARS CoV-2 infection may impact daily functioning and be harbingers of future neurodegeneration and overt neurologic dysfunction. Here we will define neurological complications related to mild SARS CoV-2 infection, using sophisticated neuroimaging, neuropsychiatric examinations and detailed testing of neurocognitive functions, and will characterize their nature and scope as the first necessary steps toward addressing the problem.

PI_NAMEs: DAILY, JOHANNA PATRICIA (contact);LIPTON, MICHAEL LAWRENCE

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 2019-nCoV;acute stroke;Address;Anxiety;Area;asymptomatic COVID-19;Attention;Body mass index;Brain;brain dysfunction;Brain imaging;Brain Injuries;brain magnetic resonance imaging;Brain region;brain tissue;brain volume;Caring;Cellular Assay;Characteristics;Clinical;cohort;comorbidity;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 patient;COVID-19 survivors;COVID-19 vaccination;daily functioning;Data;Detection;Disadvantaged minority;Enrollment;ethnic diversity;Ethnic Origin;executive function;Exhibits;experience;follow-up;Functional disorder;Future;Healthcare;High Prevalence;Hypoxia;Iceberg;Image;Impaired cognition;Individual;Infection;Influenza;Injury;Laboratories;longitudinal design;Magnetic Resonance Imaging;Measures;men;Minority Groups;Moods;Morbidity - disease rate;Nature;Nerve Degeneration;neurobehavioral;Neurocognitive;neurocognitive test;Neurodegenerative Disorders;neuroimaging;Neurologic;Neurologic Dysfunctions;neuropsychiatry;New York City;novel;older adult;pandemic disease;Participant;Patients;Performance;Persons;Populations at Risk;Positioning Attribute;post SARS-CoV-2 infection;pre-pandemic;public health relevance;Race;racial diversity;Recording of previous events;Reporting;Respiratory Tract Infections;Risk;Risk Factors;Sampling;SARS-CoV-2 infection;screening;Serology;severe COVID-19;sex;Short-Term Memory;Signal Transduction;Social isolation;Stress;Stroke;Structure;study population;Symptoms;systemic inflammatory response;T-Lymphocyte;Thick;Urban Population;Variant;Woman;young man;young woman

PROJECT_TITLE: Characterizing Persistent Subclinical Neurobehavioral Effects of COVID-19 in a Diverse Urban Population

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: TROY

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

PHR: NARRATIVE The overall goal of this academic-FDA partnership R01 project is to generate diverse training and challenging testing datasets of low-dose CT (LDCT) scans, prototype a virtual CT workflow, and establish an evaluation methodology for AI-based imaging products to support FDA marketing authorization. Upon completion, our Adversarially Based CT (ABC) workflow/platform will be made publicly available, and readily extendable to other imaging modalities and other diseases. This ABC system will be shared through the FDA’s Catalog of Regulatory Science Tools, and uniquely well positioned to greatly facilitate the development, assessment, and translation of emerging AI-based imaging products.

PI_NAMEs: JIA, XUN ;MUELLER, KLAUS ;WANG, GE  (contact);ZENG, RONGPING

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Acceleration;Address;adversarial learning;Agreement;algorithmic bias;Anatomy;Artificial Intelligence;Authorization documentation;Big Data;Black Box;Bypass;Catalogs;Chest;Classification;Clinical;clinical application;clinical predictors;clinical translation;clinically relevant;Code;Communities;Computer software;Data;Data Set;deep learning;deep neural network;Detection;Development;Diagnostic;Disease;Effectiveness;Elements;empowerment;Ensure;Evaluation;Evaluation Methodology;federated learning;Feedback;Future;Generations;Goals;Head;Human;Image;Image Analysis;image processing;image reconstruction;imaging modality;improved;Individual;Industrialization;Infrastructure;innovation;interest;Internet;Label;low dose computed tomography;lung cancer screening;Machine Learning;Mainstreaming;Marketing;Masks;Medical;Medical Imaging;Medicine;Methods;Modeling;Nature;novel strategies;Pathologic;Pathway Analysis;patient privacy;Patients;Performance;Play;Population;Positioning Attribute;prototype;Publishing;radiomics;reconstruction;Regulation;Research;Research Personnel;Retrieval;Role;Running;Safety;Sampling;Science;Semantics;simulation;software as a medical device;System;Techniques;Testing;Texas;tomography;tool;Training;Translations;Universities;Validation;Vendor;virtual;virtual patient;web site;Work;X-Ray Computed Tomography

PROJECT_TITLE: Adversarially Based Virtual CT Workflow for Evaluation of AI in Medical Imaging


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Neurosciences;Pediatric;Prevention;Rehabilitation

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE  Although many prelingually-deaf infants who receive a cochlear implant do not develop optimal auditory perception skills, clinical auditory speech perception tests are not administered until children are approximately 4 years old. The proposed research will investigate how perception of acoustic modulation, an important factor for speech understanding, develops in CI infants and how it predicts later speech perception. This work will help lead to clinical measures of device efficacy and auditory benefit for CI infants which will enable earlier, and more impactful, clinical interventions.

PI_NAMEs: HORN, DAVID LOUIS (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 10 year old;4 year old;8 year old;Acoustics;Address;Adult;Age;Auditory;auditory deprivation;Auditory Perception;behavior test;Child;Chronology;Clinical;clinical care;Clinical Management;Cochlear Implants;Communication;congenital hearing loss;deaf;Development;Devices;Early identification;Early Intervention;Early treatment;experience;experimental study;Frequencies;Goals;Habilitation;Hearing;hearing impairment;Implant;implantation;Individual;infancy;Infant;Intervention;Lead;Longitudinal Studies;Measures;Methods;Modification;Noise;normal hearing;oral communication;Outcome;Patients;Pattern;Perception;Peripheral;postnatal;Procedures;programs;Psychoacoustics;Research;Resolution;Signal Transduction;skills;Speech;Speech Perception;Speech Sound;temporal measurement;Testing;Time;Work

PROJECT_TITLE: Development of Sensitivity to Acoustic Modulation in Infants who use Cochlear Implants

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]