NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care;Social Determinants of Health

PHR: Theoretically informed, culturally grounded, and psychometrically sound access metrics are needed to hold governments and healthcare systems accountable for making mental health services accessible to all people, and to help design and evaluate new programs and policies focused on improving access. This proposed collaboration between investigators at the University of Ibadan in Nigeria and the University of Washington in the United States will develop and evaluate a patient-centered metric of perceived access that is ready to use for policy evaluations, quality improvement, and mental health services research in Nigeria. Investigators will work closely with patient, provider and policy stakeholders in Nigeria to ensure that the access metric is comprehensive, culturally appropriate, and actionable for healthcare systems and local and federal ministries of health.

PI_NAMEs: FORTNEY, JOHN C. (contact);KOLA, LOLA

PROGRAM_OFFICER_NAME: CUBILLOS, LEONARDO

PROJECT_TERMS: access disparities;Accountability;Address;Anxiety;Area;Attitude;barrier to care;Caregivers;Caring;cognitive interview;Collaborations;Consensus;Country;design;Development;Disparity;Federally Qualified Health Center;Funding;Goals;Government;graduate student;Health;health disparity;Health Personnel;Health Policy;Health Services Accessibility;Health Services Research;Health Surveys;Healthcare Systems;Human Rights;Improve Access;improved;Individual;instrument;Insurance;Intervention;Interview;Leadership;Learning;Local Government;low and middle-income countries;Measures;medical specialties;Mental Depression;Mental disorders;Mental Health;mental health organization;Mental Health Services;Mentors;Monitor;National Institute of Mental Health;Nigeria;Nigerian;patient oriented;Patients;Perception;Performance;Persons;Policies;Policy Analysis;Policy Maker;Population;population based;preference;prevent;primary care setting;primary health center;Process;programs;Property;Provider;Proxy;Psychiatry;Psychometrics;Public Health;Qualitative Research;Reporting;Research;Research Activity;Research Personnel;Risk;rural setting;Sampling;Scheme;social determinants;Sociology;sound;Strategic Planning;Support Groups;Surveys;Testing;testing access;therapy design;Time;United States;United States Department of Veterans Affairs;Universities;Washington;Work;World Health Organization

PROJECT_TITLE: Developing and Evaluating a Perceived Access Metric for Global Mental Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (04)]


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Sexual minority adolescents are over 4.5 times more likely to report attempting suicide than their heterosexual peers, for which family context (e.g., parental acceptance or rejection) is a major factor. Although parental acceptance vitally impacts adolescents’ healthy development, little is known about how parents of sexual minorities get to acceptance. Using a family systems perspective, the goal of this research is to explore parents’ mental health and their help-seeking behaviors to navigate their child’s coming out and foster supportive, accepting relationships.

PI_NAMEs: BLOSNICH, JOHN RUDOLPH (contact);DE LUCA, SUSAN MARIE

PROGRAM_OFFICER_NAME: GOGINENI, ARUNDHATI

PROJECT_TERMS: 14 year old;Address;Adolescent;Age;Attitude;Behavior;Cause of Death;Child;cohort;Communities;Complex;contextual factors;cost;Data;depressive symptoms;Development;Distress;effectiveness evaluation;experience;Exploratory/Developmental Grant;Family;family support;Feeling suicidal;Fostering;Gays;gender minority;gender minority group;Generations;Goals;Health;health disparity;Health equity research;help-seeking behavior;Heterosexuals;high school;High School Student;Home;implementation efforts;implementation study;improved;Individual;interest;Intervention;Interview;Lesbian;Lesbian Gay Bisexual;Life;Literature;Longitudinal Surveys;Medical;Medical emergency;Mental Health;Methods;National Institute on Minority Health and Health Disparities;Nature;parental role;Parents;Pathway interactions;peer;Personal Satisfaction;Phase;Population;Positioning Attribute;Prevention;Process;Reaction;recruit;reducing suicide;Reporting;Research;Resources;Respondent;Rest;Risk;Risk Factors;Role;Sampling;Schools;Sex Orientation;sexual disparity;sexual minority;sexual minority health disparity;sexual minority youth;social;social determinants;Stress;Structure;Suggestion;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Surveys;System;Testing;therapy development;Time Study;Victimization;Work;young adult

PROJECT_TITLE: The Roles of Parental Mental Health and Help-Seeking: Utilizing a Family Systems Approach to Upstream Suicide Prevention for Sexual Minority Youth

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: This project will enhance oral swab (OS) testing as a novel, non-invasive means to diagnose tuberculosis (TB), especially in community settings. OS testing has the potential to simplify TB diagnosis, improve the care of many TB patients, and enable active case-finding strategies that will reduce TB transmission. Thus, this project could transform the global fight against TB.

PI_NAMEs: CANGELOSI, GERARD A (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Archives;Bacillus;Biological;Biomass;Caring;case finding;Cells;Clinical;Clinical Research;Collection;Communities;community setting;cost effectiveness;Data;design;Detection;detection sensitivity;Diagnosis;DNA;efficacy evaluation;Evaluation;fighting;Future;Grant;health care settings;high risk population;Human;improved;Incentives;Individual;Institution;Laboratories;Methods;Mycobacterium tuberculosis;novel;Nucleic Acid Amplification Tests;Oral;Oral Tuberculosis;Painless;pathogen;Patients;Persons;point of care;Preparation;Prevalence;Process;Protocols documentation;Pulmonary Tuberculosis;Reference Standards;Research Personnel;Resources;response;Risk;Risk Factors;Running;Sampling;screening;South Africa;Sputum;Surveys;Swab;Symptoms;Technology;Testing;Tongue;tongue dorsum;transmission process;Tuberculosis;Tuberculosis diagnosis;Use Effectiveness;Viscosity;worker safety;Workplace

PROJECT_TITLE: High-sensitivity tongue swab testing for tuberculosis

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Rare Diseases;Skin Cancer

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROGRAM NARRATIVE The Precision Imaging to Evaluate Kaposi Sarcoma (PRIME-KS) study addresses the urgent need for precision in Kaposi Sarcoma monitoring among people living with HIV in Low and Middle Income Countries. SkinScan3D offers an efficient, low-cost, and accessible solution to make monitoring less burdensome and more accurate for patients and providers. This transformative technology will advance health equity globally.

PI_NAMEs: ODENY, THOMAS  (contact);SEMEERE, AGGREY SEMWENDERO

PROGRAM_OFFICER_NAME: LIDDELL HUPPI, REBECCA

PROJECT_TERMS: Address;Adverse effects;Affect;Africa;African;African American population;Agreement;AIDS clinical trial group;Alopecia;Area;Artificial Intelligence;Black race;Bone Marrow Suppression;Calibration;Cancer Etiology;Cardiotoxicity;Cessation of life;Clinic;Clinical;Clinical assessments;clinical care;clinical practice;Clinical Trials;Color;Computer software;Consumption;cost;cost effective;Country;Darkness;design;Devices;Discover, Design, Build, and Test Framework;Educational workshop;Effectiveness;Electricity;Ensure;experimental study;financial toxicity;Focus Groups;Health care facility;health equity;Height;HIV;HIV therapy;Human;human centered design;Image;implementation cost;improved;innovation;instrument;Internet;Judgment;Kaposi Sarcoma;Kenya;Laboratories;lens;Lesion;Liquid substance;Location;low and middle-income countries;Malawi;Malignant Neoplasms;Manuals;manufacture;Maps;Measurement;Measures;men;Methods;microcosting;Monitor;Mozambique;Neuropathy;new technology;Nurses;open source;operation;Outcome;Participant;Patients;Performance;Persons;Phase;preference;premature;Procedures;Protocols documentation;prototype;Provider;Public Health;Quality of life;racial disparity;Randomized;recruit;Reproducibility;Resolution;routine care;secondary analysis;Site;Skin;Skin Kaposi's Sarcoma;skin lesion;standard of care;System;Technology;Testing;Three-Dimensional Image;Time;Time and Motion Studies;Toxicity due to chemotherapy;Translating;treatment response;Uganda;usability;user-friendly;Variant

PROJECT_TITLE: PRecision IMaging to Evaluate Kaposi Sarcoma (PRIME-KS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-Q (M1)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BERKELEY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative A significant limitation of the current single-molecule assay (SIMOA) technology is its reliance on bulky instrumentation and optics for automated sample preparation and high-sensitivity detection. This project seeks to advance the technology by creating a miniaturized SIMOA platform. This platform will seamlessly integrate thousands of microfluidic channels, sub-µm sized pores, and electrodes with detection readout circuits, all within a millimeter-sized semiconductor chip. This allows for high-throughput counting of all immuno-complexes activated by target molecules. Thanks to its compact design and portability, this device holds promise for near- bedside and Point-of-Care diagnostics in resource-constrained settings.

PI_NAMEs: CHIEN, JUN-CHAU  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, KRISTIN HEDGEPATH

PROJECT_TERMS: Address;Algorithms;alpha synuclein;analog;Antibodies;Benchmarking;Binding;Biological Assay;Biological Markers;Biological Sciences;biomarker panel;Bite;Breathing;clinical practice;commercialization;Complex;Controlled Environment;cost;Coupled;cytokine;design;Detection;detection sensitivity;Devices;Diagnostic;Diagnostic Procedure;diagnostic tool;digital;Disease;Electrodes;Electronics;Environment;Enzyme-Linked Immunosorbent Assay;Equipment;Event;experience;Flow Cytometry;Future;Glial Fibrillary Acidic Protein;Individual;Infrastructure;instrument;instrumentation;integrated circuit;Knowledge;Ligands;Magnetic nanoparticles;Magnetism;Measurement;Measures;meter;Methodology;Microfluidics;millimeter;miniaturize;Monitor;nanoparticle;nanopore;Neurodegenerative Disorders;Neurologic;Noise;Optics;parallel processing;Physiologic pulse;Plasma;point of care;point-of-care diagnostics;Polystyrenes;portability;Precision Health;Preparation;Process;protein biomarkers;Proteins;Reader;Relaxation;Resistance;Resource-limited setting;Resources;Sampling;Semiconductors;sensor;Serum;signal processing;Signal Transduction;single molecule;skills;Sorting;Source;superconducting quantum interference device;System;Systems Integration;Technology;Testing;Time;Validation;Work

PROJECT_TITLE: SEMI-SIMOA: A Chip-scale Flow-based Single-Molecule Assay at the Point-of-Care using Semiconductor Technology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-Y (82)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative The project proposes to use transcranial magnetic stimulation to modulate the brain circuitry linked to auditory hallucinations using a novel stimulation site selection and stimulation mode combination, and to determine whether it would correct the circuitry abnormality.

PI_NAMEs: CHEN, SHUO ;DU, XIAOMING ;HONG, L ELLIOT ELLIOT (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: active method;Acute;Address;anatomic imaging;Antipsychotic Agents;Area;association cortex;Auditory;Auditory area;Auditory Hallucination;Blinded;Brain;brain circuitry;Clinical;clinical efficacy;Controlled Clinical Trials;Data;Decision Making;design;Disease;Dose;electric field;experience;Follow-Up Studies;Functional Magnetic Resonance Imaging;functional outcomes;Hearing;improved;indexing;Individual;Linguistics;Link;Location;Maintenance;Modeling;neural circuit;neuroimaging;neuroregulation;novel;novel strategies;Outcome Assessment;Participant;Patient Recruitments;Patients;Pharmaceutical Preparations;Phase;Prefrontal Cortex;Quality of life;Randomized;Randomized Controlled Clinical Trials;recruit;Refractory;repetitive transcranial magnetic stimulation;Research;Rest;Role;Schizophrenia;schizophrenia spectrum disorder;Site;Symptoms;System;Techniques;Testing;trait;Transcranial magnetic stimulation;treatment duration;treatment effect;treatment site;Visit;Voice

PROJECT_TITLE: Alternative Stimulation Mode and Location for Auditory Hallucination Neuromodulation Treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (03)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Fetal Tissue;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE We have implicated human-specific cerebellar developmental features in the pathogenesis of the most common brain birth defects and pediatric brain tumours. To better appreciate the cellular basis of cerebellar disease a more comprehensive study on the cellular behavior and molecular identity of cells residing in the normal developing human cerebellum needs to be carried out. The experiments proposed in this grant will help improve our understanding of the biology of normal cerebellar development and provide vital clues on the potential mechanisms of cerebellar birth defects and tumors.

PI_NAMEs: HALDIPUR, PARTHIV  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Address;Age;Anatomy;Animal Model;Animals;ATAC-seq;Automobile Driving;Biological Assay;Biology;Brain;Bromodeoxyuridine;cell behavior;Cell Cycle;Cells;Cerebellar Diseases;Cerebellum;Cerebral cortex;Characteristics;Childhood Brain Neoplasm;cognitive function;college;Conceptions;Congenital Abnormality;Data;Dedications;Development;Developmental Biology;developmental disease;Disease;Embryonic Development;epigenomics;experimental study;fetal;Future;Genes;Glutamates;Goals;Grant;Human;human fetus tissue;human imaging;human model;Image;Immunohistochemistry;improved;In Situ Hybridization;In Vitro;in vitro Assay;indexing;Knowledge;Label;Language;Length;Lip structure;London;Macaca;malformation;Measures;Medulloblastoma;microscopic imaging;Modeling;Molecular;Morphology;Motor;Mus;Neurons;nonhuman primate;Nuclear;Nuclear RNA;Pathogenesis;Pathway interactions;Physiologic pulse;progenitor;programs;Proliferating;Protocols documentation;Purkinje Cells;Resources;Rodent;Role;Sampling;Satiation;Series;Slice;spatiotemporal;Speech;stem cell expansion;stem cells;Structure;Study models;subventricular zone;Time;Tissues;transcriptomics;tumor;Universities;Ventricular;Work

PROJECT_TITLE: In vitro approaches to study human cerebellar development

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Digestive Diseases;Dissemination and Implementation Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Methamphetamine;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE This R36 dissertation study examines transitions from injecting to smoking drugs (predominantly fentanyl and methamphetamine) among people who inject drugs (PWID) in the San Diego- Tijuana border region. Such transitions may help reduce infectious disease (e.g., HIV, HCV) and overdose morbidity and mortality if sufficient quantities of safer smoking supplies are accessible (e.g., through syringe service programs; SSPs). By examining the multilevel (e.g., individual, organizational, structural) factors driving these transitions in drug consumption patterns and related implementation considerations for distributing safer smoking supplies through SSPs, this project will inform efforts to improve the delivery of prevention services and reduce the high burden of infectious diseases and overdose among people who use drugs.

PI_NAMEs: EGER, WILLIAM HENRY (contact)

PROGRAM_OFFICER_NAME: PARKER, ERIN MARGARET

PROJECT_TERMS: Address;Area;Automobile Driving;Bacterial Infections;Behavior;Border Crossings;California;career;Cities;Client;Cohort Studies;Communicable Diseases;Communities;Consumption;Data;Development;disease transmission;Drug usage;Drug user;Equipment;evidence base;Evidence based intervention;Exhibits;experience;Exploration, Preparation, Implementation, and Sustainment;Face;Fentanyl;Frequencies;Glass;Goals;Harm Reduction;Health Services Accessibility;Hepatitis C;Hepatitis C virus;Heroin;HIV;implementation strategy;improved;Incidence;Individual;informant;Injecting drug user;injection drug use;Injections;innovation;Intake;interest;Intervention;Interview;Law Enforcement;Link;Mentors;Methamphetamine;Methods;Mexico;Misinformation;Modeling;Morbidity - disease rate;mortality;National Institute of Drug Abuse;Needle-Exchange Programs;North America;Opioid;outreach;Overdose;overdose risk;Pattern;peer;Persons;Pharmaceutical Preparations;Police;Policies;Politics;Population;Prevention;prevention service;Public Health;Research;Research Project Grants;Resource-limited setting;Resources;response;Risk;Risk Reduction;Sampling;scale up;service delivery;service programs;Services;Silicones;Smoke;Smoking;social;sociodemographics;Stigmatization;Structure;Subgroup;substance use;Time;trafficking;Training;treatment services;trend;Viral hepatitis;Xylazine

PROJECT_TITLE: Determinants of transitioning from injecting to smoking fentanyl and methamphetamine and implications for harm reduction implementation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Infectious Diseases;Rare Diseases

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative This project will investigate the performance of selective whole genome amplification for the genome sequencing of Mycobacterium leprae, the causative agent of leprosy. Success in this project's stated aims will lead to the development of a rapid, sensitive, and cost-effective method to sequence M. leprae from human and armadillo samples successfully.

PI_NAMEs: AVANZI, CHARLOTTE  (contact)

PROJECT_TERMS: Americas;Animals;Bacillus;Bacteria;Bacterial DNA;Characteristics;Clinical;Complex;cost;cost effective;Coupled;Data;Dedications;Development;Diagnostic;DNA;Drug resistance;Engineering;Epidemiology;Evaluation;Evolution;experimental study;Family Dasypodidae;Generations;Genome;genome sequencing;Genomics;Growth;Human;human DNA;improved;In Vitro;in vivo Model;insight;Laboratories;Leprosy;Libraries;Methods;Molecular;Mus;Mycobacterium leprae;nasal swab;novel strategies;pathogen;Pathogenicity;Patients;Performance;Physiology;Polymerase;Preparation;prevent;Process;Reagent;Recombinants;Research;Research Personnel;resistance mechanism;Resources;Risk;RNA;Sampling;sequencing platform;skin biopsy;Specimen;Stains;success;Time;Tissue Sample;Tissues;tool;transmission process;whole genome;Work;Zoonoses

PROJECT_TITLE: New approaches to sequence genomes of Mycobacterium leprae from clinical and field specimens


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Pediatric;Primary Health Care

ORG_CITY: SAN DIEGO

ORG_DEPT: PEDIATRICS

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE There is an urgent need to focus on evidence-based interventions (EBIs) that improve mental health services for autism and optimize outcomes for this priority, complex population. We propose a Hybrid Type 2 randomized trial examining the effectiveness and implementation of an autism EBI targeting executive functioning, Unstuck and On Target, in community mental health settings. Findings have the potential to transform implementation and service quality for the high priority population of autistic youth as well as youth generally.

PI_NAMEs: DICKSON, KELSEY S (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Address;adolescent with autism spectrum disorder;Affect;Age;Anxiety;Area;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavioral;Caring;Child;Child Mental Health;child mental health service;Clinical;Cognitive;Communities;Complex;cost;Data;Diagnostic;Disparity;Educational Intervention;effective intervention;Effectiveness;effectiveness evaluation;effectiveness research;effectiveness/implementation trial;Evidence based intervention;Executive Dysfunction;executive function;Funding;gain of function;Goals;Health;Hybrids;Impairment;implementation outcomes;implementation strategy;improved;Individual;Intervention;life time cost;Mediating;Mediator;Mental Depression;Mental Health;Mental Health Services;Motivation;National Institute of Mental Health;Outcome;Pattern;Penetration;Perception;pilot test;Play;Population;Protocols documentation;Psychotherapy;Public Health;Quality Indicator;randomized trial;Research;Research Domain Criteria;Role;Self Efficacy;Services;Symptoms;Target Populations;Testing;therapy design;Training;Vocation;Work;Youth

PROJECT_TITLE: Hybrid Effectiveness-Implementation Trial of an Executive Functioning Intervention for Children's Mental Health Services

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Pain Research;Prevention

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE: The proposed study will test the feasibility and acceptability of combining the Mindfulness-Based Stress Reduction (MBSR) program with an open-label placebo treatment that holds significant promise for enhancing analgesic effects for chronic pain. This single-site feasibility trial is designed to furnish essential data and insights that will guide the planning of a larger fully-powered multi-site clinical trial. If subsequent fully-powered clinical trials confirm the efficacy of this combined approach, it has the potential to advance the care of millions of adults suffering from chronic pain, leveraging the accessibility and safety of mindfulness and open-label placebo treatments.

PI_NAMEs: MUN, CHUNG JUNG  (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Absence of pain sensation;acceptability and feasibility;Acute Pain;Adherence;Adult;Affect;Aftercare;Analgesics;arm;Attention;Awareness;Biochemical;Cardiovascular Diseases;Caring;Chronic Disease;chronic pain;chronic pain management;Clinical;clinical practice;Clinical Trials;conditioned pain modulation;Consumption;Dairying;Data;Deception;design;Detection;Development;Diabetes Mellitus;diaries;disability;Effectiveness of Interventions;efficacy trial;endogenous opioids;Ethical Issues;Ethics;Evaluation;Feasibility Studies;feasibility testing;feasibility trial;follow-up;Foundations;Frequencies;Future;Goals;Grant;Guidelines;improved;Individual;innovation;insight;Intervention;Length;Measures;Mediating;medication compliance;Meta-Analysis;Mind-Body Intervention;mindfulness;mindfulness intervention;mindfulness meditation;Mindfulness Training;mindfulness-based stress reduction;Monitor;Multi-Institutional Clinical Trial;non-opioid analgesic;open label;opioid use;Outcome;Pain;pain inhibition;Pain interference;pain outcome;pain relief;Participant;participant enrollment;participant retention;patient engagement;Patient Recruitments;Patient Self-Report;Patients;placebo analgesia;Placebos;Play;Population;Postoperative Period;primary outcome;Procedures;programs;Public Health;Randomized;Randomized, Controlled Trials;Reading;recruit;Research;retention rate;Riboflavin;Risk;Safety;satisfaction;Sensory;Severities;side effect;Site;statistics;Symptoms;System;Testing;Therapeutic Effect;Tracer;Treatment Efficacy;treatment strategy;urinary;Videoconferencing;Visit;week trial

PROJECT_TITLE: Investigating the Feasibility of Combining Mindfulness Intervention and Open-Label Placebo Treatment for Chronic Pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 BH (02)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: FAIRBANKS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ALASKA FAIRBANKS

ORG_STATE: AK

PHR: Project Narrative  Numerous populations, including Indigenous and those from rural backgrounds, are significantly underrepresented in the biomedical workforces that addresses health concerns of local and global significance. The Research Advising and Mentoring Professionals for Underrepresented Peoples (RAMP UP) program will develop, deliver, and evaluate a customized, holistic mentor training program that focuses on supporting faculty, graduate students, and research staff located at institutions that serve underrepresented undergraduate students in biomedical research. This intensive training will administer a supportive and culturally appropriate approach to create a network of trained mentors who possess the knowledge and skills they require to provide academic advising, research mentoring, and psychosocial support to the students they serve; especially those students who are typically underrepresented in the biomedical fields.

PI_NAMEs: LOPEZ, ELLEN DS;REYNOLDS, ARLEIGH JAMES (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Academic advising;Address;Alaska;Awareness;Behavioral;Biomedical Research;career;Career Choice;college;Dedications;Degree Completion;Educational Curriculum;Ensure;Evaluation;experience;Faculty;faculty support;Funding;graduate student;Health;Home;Indigenous;Individual;Inequity;Infrastructure;Institution;intervention program;Knowledge;Learning;Measures;Mentors;Participant;Personal Satisfaction;Persons;Policies;Population;Process;programs;Psyche structure;Psychosocial Assessment and Care;recruit;Research;Research Support;Resources;Rural;Science, Technology, Engineering and Mathematics;Self Efficacy;skills;STEM field;student mentoring;student training;Students;success;support network;Teacher Professional Development;Training;Training Activity;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-V (IP)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Recovery Support Services;Social Determinants of Health;Substance Misuse

ORG_CITY: LEXINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: This project highlights the urgent need to address the multi-level impact of the CLS on OUD treatment and recovery to combat the opioid epidemic among people involved with the CLS. The Substance Use and Mental Health Services Administration defines recovery as a self-directed process, and this project examines ways in which institutions and networks limit an individual’s agency in their recovery efforts. Because substance use recovery is not merely an individual process, it is important to address barriers and facilitators at all levels of impact to best effect change and have a sustained public health impact.

PI_NAMEs: BOOTY, MARISA D. (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: addiction;Address;career;Caring;combat;Communities;community reentry;County;Creativeness;Data;Data Analyses;Disease;Environment;Evidence based intervention;experience;geographic difference;healing;Health;Health Services Administration;Health Services Research;Imprisonment;improved;Individual;innovation;Institution;internalized stigma;Justice;Kentucky;Knowledge;Language;Learning;Legal system;Length;Logistic Regressions;Longitudinal cohort study;Maximum Likelihood Estimate;Mediating;meetings;member;Mental Health Services;Methodology;Methods;Morals;Narcotics Anonymous;National Institute of Drug Abuse;Opioid;opioid epidemic;opioid use;opioid use disorder;Outcome;outreach;overdose death;Overdose reduction;Participant;Pathway Analysis;Persons;Pharmaceutical Preparations;Play;Predictive Factor;Principal Investigator;Prisons;Process;Protocols documentation;Provider;Public Health;Quality of Care;Recommendation;Recovery;recovery services;Research Personnel;response;Risk;Role;Safety;Scientific Advances and Accomplishments;Self Direction;service delivery;service engagement;Services;Social Network;Social support;substance abuse treatment;substance use;Substance Use Disorder;substance use treatment;Support Groups;Surveys;Symptoms;Text;Transcript;treatment program;treatment services;United States National Institutes of Health;uptake

PROJECT_TITLE: Examining the Impact of the Criminal Legal System on Opioid Use Disorder Treatment and Recovery: A Socioecological Perspective

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

PHR: PROJECT NARRATIVE Pregnancy is a highly dynamic time when substance use behaviors change, often dramatically. Initial evidence suggests that co-exposure to alcohol and cannabis in utero may carry additional risks beyond those conferred from either substance alone, and these risks may extend to paternal co-use around the time of conception. The purpose of this developmental proposal is to gather information about preconceptional and prenatal alcohol and cannabis use, for both the pregnant individual and the biologic father, to support the feasibly of a larger cohort in the future.

PI_NAMEs: BANDOLI, GRETCHEN E. (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: addiction;adverse outcome;Affect;Age;aged;Alcohol consumption;alcohol consumption during pregnancy;alcohol exposure;Alcohols;Animal Model;Anxiety;Attention;Behavior;behavior change;Biological;Cannabis;Characteristics;cohort;Cohort Studies;Complement;Conceptions;Counseling;County;Data;Development;Developmental Process;early pregnancy;Enrollment;Epidemiologist;Exposure to;Fathers;Fetal Alcohol Spectrum Disorder;Fetal Development;fetal marijuana exposure;Future;Individual;information gathering;Intervention;Interview;Joints;Learning;Legal;Literature;male;marijuana use;maternal alcohol use;Maternal-fetal medicine;Methods;Modeling;Nausea;offspring;Outcome;Paternal Exposure;Pattern;Perinatal;Persons;Pilot Projects;Population;post pregnancy;Pregnancy;pregnant;Pregnant Women;Premature Birth;prenatal;Psychiatrist;recruit;reduced alcohol use;Reporting;reproductive;Research;Review Literature;Risk;Small for Gestational Age Infant;Specialist;substance use;success;Surveys;Techniques;Time;trend;Woman

PROJECT_TITLE: Parental alcohol and cannabis before and during pregnancy: a pilot study

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 DD (05)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Inflammation and metabolism are tightly linked processes with significant consequences in human disease. We identified a critical inflammatory pathway in the liver that regulates systemic metabolism and weight gain through post-translational processes. Using a suite of novel transgenic mice, the proposed studies will investigate the pivotal role this pathway plays in governing whole body energy balance and identify the factors responsible.

PI_NAMEs: PATEL, SURAJ J (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Adipose tissue;Body Weight;Chronic;Complex;Data;Dependovirus;Diet;diet-induced obesity;Eating;Endocrine;energy balance;Energy Metabolism;Engineering;Epidemic;Fatty Liver;Functional disorder;gain of function;Genes;Goals;Health;Hepatic;Hepatocyte;Human;human disease;improved;In Vitro;Indirect Calorimetry;Inflammation;Inflammatory;Innate Immune System;innovation;Insulin Resistance;insulin sensitivity;Interferons;IRF3 gene;ISG15 gene;Label;Link;Liver;liver ablation;loss of function mutation;LoxP-flanked allele;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic dysfunction;Metabolism;Mitochondria;Molecular;Morbidity - disease rate;mortality;Motor Activity;Mus;Mutation Analysis;Natural Immunity;Nervous System;novel;novel therapeutics;Obesity;obesity treatment;Organ;overexpression;Overnutrition;oxidation;Pathway interactions;Patients;Peptide Hydrolases;Play;Process;Production;Proteins;Proteomics;Regulation;Resistance;Role;Signal Transduction;Site;Small Interfering RNA;System;Testing;Therapeutic;Transgenic Mice;Translation Process;Ubiquitin;ubiquitin-protein ligase;Variant;Weight;Weight Gain

PROJECT_TITLE: Post-translational control of whole body energy balance by hepatic ISGylation

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Even after FDA approval of a drug, it is common for unforeseen adverse drug reactions to arise, and these adverse reactions cause millions of emergency department visits and hundreds of thousands of hospitalizations annually in the U.S. Predicting adverse drug reactions is difficult as doing so requires knowing how a drug may interact with all proteins in the human body. We propose a computational method for adverse drug reaction prediction that leverages recent advances in structural biology and bioinformatics to tackle this challenge.

PI_NAMEs: CARPENTER, KRISTY  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;adverse drug reaction;Adverse reactions;Affinity;Algorithms;Binding;Binding Proteins;Binding Sites;Bioinformatics;career;Cessation of life;Clinical Trials;Collaborations;Communication;Computing Methodologies;Data;Databases;deep learning;Detection;dosage;Drug Binding Site;Drug Design;drug development;Drug Interactions;drug repurposing;Drug Targeting;education resources;Educational process of instructing;Emergency department visit;Environment;Event;experience;Failure;Goals;graduate student;Graph;Health;Hospitalization;Hospitals;Human;Human body;improved;Informatics;Knowledge;Learning;Ligand Binding;Ligands;Location;member;Membrane Proteins;Mentors;Methods;Molecular;Molecular Structure;Network-based;novel;novel therapeutics;Oral;Pathway Analysis;Patients;Pharmaceutical Preparations;pharmacologic;prediction algorithm;protein data bank;protein structure;Protein Structure Databases;protein structure prediction;Proteins;Proteome;Recording of previous events;Research;Research Personnel;Resources;response;Scanning;small molecule;structural biology;Structure;success;Surface;symposium;Therapeutic Effect;Toxic effect;Training;Universities;Visit;wasting;Work;Writing

PROJECT_TITLE: Predicting adverse drug reactions via networks of drug binding pocket similarity


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: Project Narrative The most frequent genomic alteration in pediatric low-grade gliomas is a rearrangement that creates a fusion between the oncogene BRAF and the uncharacterized protein KIAA1549. Inhibitors which block the function of this fusion are effective but cause significant toxicity and require continuous dosing throughout childhood. The goal of this project is to define new therapeutic targets in KIAA1549-BRAF mutant pLGGs, with a particular focus on characterizing how the POMT complex regulates KIAA1549-BRAF activity.

PI_NAMEs: MISEK, SEAN ALEXANDER (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Affect;Binding;BRAF gene;Brain;cell growth;Cell membrane;Cells;Childhood;Chronic;Clinical;cofactor;Complex;CRISPR screen;Dependence;Development;DNA Sequence Alteration;Dose;Dose Limiting;Essential Genes;Event;extracellular;Genes;Genetic Predisposition to Disease;Genome;genome-wide;GIT2 gene;Goals;Human;inhibitor;Integral Membrane Protein;Knowledge;Length;loss of function;MAP Kinase Gene;Mediating;member;Membrane;Modeling;mutant;Mutation;N-terminal;new therapeutic target;novel therapeutics;Oncogenes;Oncogenic;Pathway interactions;Patients;pediatric low grade glioma;Plasma Enhancement;Post-Translational Protein Processing;prevent;protein-O-mannosyltransferase 1;protein-O-mannosyltransferase 2;Proteins;Proteome;relapse prevention;Resistance;Signal Transduction;Site;Testing;Therapeutic;therapeutic target;Toxic effect;Transmembrane Domain;tumor;Withholding Treatment

PROJECT_TITLE: Identifying genetic vulnerabilities in KIAA1549-BRAF mutant pediatric low-grade gliomas


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE The work in this fellowship proposal will extend our understanding of notochord biology and how this tissue contributes to a healthy spine. Importantly, mutations in INPPL1 cause the rare endochondral bone disorder, Opsismodysplasia (OPS). Therefore, this work in zebrafish may reveal a conserved role for inppl1a/INPPL1 in skeletal development and may also deepen our understanding of human endochondral bone disorders, such as OPS.

PI_NAMEs: VOIGT, BRITTNEY  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Adult;Anterior;Atlases;Basement membrane;Biogenesis;Biology;Biotinylation;Birth;bone;Bone Diseases;Candidate Disease Gene;cartilaginous;Cell membrane;Cell secretion;Cell Size;Cell Volumes;Cells;Chest;Chordata;Chordoma;Clustered Regularly Interspaced Short Palindromic Repeats;Cytoplasm;Databases;Defect;Deposition;Development;Diameter;Disease;Embryo;embryo tissue;Epithelium;Extracellular Matrix;Fellowship;Fertilization;Fractionation;Future;Genes;Genetic;genetic approach;Genetic Screening;GTPase-Activating Proteins;Health;Human;Image Analysis;in vivo;Inositol;INPPL1 gene;intervertebral disk degeneration;Investigation;Knowledge;Label;late endosome;Length;Lesion;Link;Locomotion;loss of function;malformation;Maps;marker transgenes;Mass Spectrum Analysis;mechanical properties;Mechanical Stress;Mechanics;Membrane;mineralization;Modernization;Molecular Genetics;mouse model;mutant;Mutation;notochord;notochord development;opsismodysplasia;Optics;Pattern;pharmacologic;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Physiologic calcification;Plasma Cells;Polyphosphates;Predisposition;premature;pressure;Process;protein complex;Proteins;Proteomics;quantitative imaging;Resources;Rod;Role;scoliosis;Severities;Siblings;Signal Pathway;skeletal;Skeletal Development;skeletal disorder;Spinal Curvatures;spine bone structure;Structure;Swelling;Swimming;Techniques;Testing;Thick;Time;Tissues;trafficking;Tretinoin;Vacuole;Vertebral Bone;Vertebral column;Vertebrates;Vesicle;Viscosity;Work;Zebrafish

PROJECT_TITLE: Uncovering the role of inppl1a in notochord vacuolation and the development of a straight body axis.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project narrative Artificial biomolecular condensates are emerging as a groundbreaking technology to manipulate diverse cellular processes including gene regulation, metabolism, and stress. This project establishes a new class of artificial condensates using computationally-designed RNA as a building block. We will develop methods to customize RNA condensates to recruit a multitude of target molecules and to form at target cellular locations, providing tools for control of gene expression and biosensing that are immediately portable to a variety of organisms.

PI_NAMEs: FRANCO, ELISA  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Adopted;Affinity;Area;biological adaptation to stress;Biology;biophysical properties;Biosensing Techniques;Cell Physiology;Cells;cellular targeting;design;Disease;Engineering;Environment;Gel;Gene Expression;Gene Expression Regulation;Genes;Imaging Device;In Vitro;interest;Kinetics;Liquid substance;Location;Membrane;Membrane Lipids;Metabolism;Methods;Molecular;Monitor;nano;Nanostructures;Nanotechnology;Organelles;Organism;Pathway interactions;Phase;Physical condensation;portability;programs;Protein Engineering;Proteins;recruit;Research;RNA;Sampling;Science;Shapes;side effect;Signal Transduction;single molecule;Solid;spatiotemporal;Stress;Structure;Technology;Thermodynamics;tool;Toxic effect

PROJECT_TITLE: Developing synthetic RNA organelles for spatiotemporal separation, control, and monitoring in living cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Health Services;Mental Health;Mental Illness;Patient Safety;Primary Health Care

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE Depression is a prevalent and burdensome public health issue and widespread problems with antidepressant adherence, especially during the early stage of treatment, undermine the primary care treatment of depression. This study will test whether personalized daily text messages alone or combined with financial incentives improves depression outcomes. Scalable patient-facing intervention strategies that target adherence barriers are needed to support the treatment of depression in primary care to improve medication adherence and reduce depression symptoms.

PI_NAMEs: MARCUS, STEVEN C (contact);OLFSON, MARK

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;anti-depressive agents;Antidepressant adherence;arm;Behavioral;behavioral economics;Clinical;contingency management;cost effective;Counseling;Depressed mood;depressive symptoms;design;Drug Prescriptions;Education;Effectiveness;eHealth;Electronic Health Record;Evidence based treatment;financial incentive;Funding;Habits;Healthcare;improved;improved outcome;Incentives;individual patient;Intention;Intervention;intervention effect;Intervention Studies;Measures;Mediating;medication compliance;Mental Depression;National Institute of Mental Health;Outcome;Patient Compliance;Patient Noncompliance;Patient Preferences;Patients;Pharmaceutical Preparations;pill;Primary Care;primary care patient;Primary Care Physician;primary care team;primary outcome;Public Health;Quality of Care;Quality of life;Randomized, Controlled Trials;Records;relative effectiveness;Resources;response;Security;Social Functioning;Subgroup;success;Symptoms;System;tailored text messaging;Telephone;Testing;Text;Text Messaging;therapy design;Training;treatment arm;treatment as usual;trial comparing;wireless;Writing

PROJECT_TITLE: Testing tailored text reminders and financial incentives to enhance antidepressant adherence for depressed adults in primary care


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: RIVERSIDE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE Approximately 40% of Alzheimer’s Disease (AD) cases in the U.S. are due to modifiable lifestyle factors such as hypertension, obesity, physical inactivity, heavy alcohol use, and smoking. Yet, some people have access to environmental opportunities (e.g., fitness centers) that promote healthy behavior engagement, whereas others are constrained by their environments, or engage in health behaviors despite environmental constraints. This project will lead to new knowledge about modifiable health behaviors and environmental opportunities as prevention and intervention targets for promoting healthy cognitive aging in place among minoritized adults.

PI_NAMEs: ATHERTON, OLIVIA EMILE (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Adult;aging in place;Alcohols;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Atlases;Behavior;Behavioral;California;Censuses;Characteristics;checkup examination;Child;Cognitive;Cognitive aging;cognitive function;contextual factors;cost;Data;Dementia;dementia burden;dementia risk;density;Detection;Diagnosis;Disease;Economics;Environment;ethnic minority;European;Exercise;Family;Family Study;Fathers;Fitness Centers;Funding;Future;Geography;Goals;Health;Health behavior;health disparity;Health Status;Healthcare;healthy aging;Healthy Eating;Heavy Drinking;high risk;Hypertension;Immigrant;Impaired cognition;Individual;Informal Social Control;Intervention;Investigation;Knowledge;Latin America;Latino Population;Life Cycle Stages;Link;Longitudinal Studies;Mexican;middle age;Minority;Minority Groups;Modeling;modifiable lifestyle factors;Mothers;Obesity;older adult;Outcome;Persons;Physical activity;physical inactivity;Physiological;Policies;Population;prevent;Prevention;Process;psychosocial;Research;resilience;Resources;Risk;Risk Reduction;Role;Sampling;Services;Smoking;social culture;socioeconomic disadvantage;substance use;Supermarket;theories;uptake;Vulnerable Populations;Work

PROJECT_TITLE: Behavior-Opportunity Gaps and Midlife Cognitive Health: Geographical Linkages to Enrich an Ongoing Longitudinal Family Study of Dementia Risk in a Minoritized Population


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Patient Safety;Social Determinants of Health

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative The proposed research is relevant to public health because it focuses on developing and supporting the “real world” assessment of strategies used to foster adoption of several safe and highly efficacious mechanical ventilation liberation and symptom management practices in healthcare systems that provide care to critically ill adults with known health disparities. We expect study results will impact the field by developing simple, yet effective, ways of accelerating the reliable uptake of evidence-based ICU interventions that will ultimately improve the care and outcomes of millions of critically ill adults annually. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to reducing illness, disability, and healthcare disparities.

PI_NAMEs: BALAS, MICHELE CHRISTINA (contact);VASILEVSKIS, EDUARD E

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acceleration;Acute;Address;Adoption;Adult;Affect;Anxiety;arm;Behavioral;behavioral economics;brain dysfunction;Budgets;care delivery;Caring;Clinical;clinical decision-making;clinically relevant;Cognitive;Collaborations;collaboratory;Communities;community partners;compare effectiveness;Complex;cost;Critical Care;Critical Illness;Data;Delirium;disability;Disparity;effectiveness evaluation;effectiveness outcome;effectiveness/implementation trial;electronic data;Electronic Health Record;Equity;evidence base;Evidence based intervention;Evidence based practice;experience;Feedback;Fostering;functional decline;Functional disorder;Goals;Health;Health Benefit;health care disparity;health disparity;Healthcare Systems;Hospital Administrators;hospital readmission;Hospitals;Hybrids;Impaired health;Impairment;implementation facilitators;implementation research;implementation science;implementation strategy;improved;improved outcome;Institutionalization;Intensive Care Units;Intervention;Knowledge;Length of Stay;Literature;Mechanical ventilation;member;Methods;Mission;Morbidity - disease rate;mortality;Neurocognitive;Outcome;Outcome Measure;Outcome Study;Pain;Patients;Performance;Pharmaceutical Preparations;Phase;Physical therapy;Population;Practice Management;primary outcome;Protocols documentation;Psyche structure;Public Health;Quality Control;Race;Randomized;Registered nurse;Research;Research Methodology;Resources;safety net;social;social norm;socioeconomics;Specialist;Survivors;symptom management;systems research;team-based care;theories;Time;United States National Institutes of Health;uptake;validation studies;Work;Workload

PROJECT_TITLE: Behavioral Economic and Staffing Strategies To Increase Adoption of the ABCDEF Bundle in the ICU (BEST-ICU)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Organ Transplantation;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE One strategy to expand the donor pool for the escalating numbers of patients who require lung transplants is recovering lungs from donors when deaths occur unexpectedly inside or outside of hospitals. Our study team developed a novel protocol that preserves lungs non-invasively for just over 3 hours after death using positive end expiratory pressure (PEEP) and supplemental oxygen. Non- invasive lung preservation initiated soon after unexpected death could markedly increase lung donation opportunities in the U.S.

PI_NAMEs: MONTGOMERY, ROBERT A;WALL, STEPHEN P (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Action Research;Advisory Committees;Aerobic;Authorization documentation;Autopsy;Bilateral;Brain Death;Bronchoscopy;Cessation of life;Chest;Chest Tubes;Circulation;Clinical;Clinical Trials;Code;Communities;community based participatory research;Complex;Country;Cryopreservation;Data;Dedications;Diagnostic;Eligibility Determination;Ethics;Europe;European;feasibility testing;Feedback;Fiber Optics;Goals;graft dysfunction;Growth;Hospitals;Hour;improved;In Situ;Interview;Laboratories;Lung;lung preservation;Lung Transplantation;Manuals;Mediation;Medical emergency;meetings;member;Metabolism;Modification;Multicenter Trials;National Heart, Lung, and Blood Institute;novel;operation;Organ;Organ Donations;Organ Preservation;Organ Procurements;Outcome;participant interview;Patients;performance tests;Perfusion;Persons;Phase;Positive-Pressure Respiration;preservation;primary outcome;prior authorization;Procedures;programs;Protocols documentation;Radiology Specialty;Recovery;Research;Research Methodology;Resuscitation;Safety;safety outcomes;screening;secondary outcome;simulation;Social Workers;Specific qualifier value;supplemental oxygen;System;Teleconferences;Testing;Time;Training;Transcript;Translating;Transplantation;Tube;Warm Ischemia;X-Ray Computed Tomography

PROJECT_TITLE: Transplanting Lungs from Uncontrolled Donation after Circulatory Death


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Hematology;Mental Health;Neurosciences;Pain Research;Pediatric;Rare Diseases;Rehabilitation;Sickle Cell Disease;Telehealth

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy (PRESENCE) will be the first study to compare the effectiveness of a cognitive behavioral therapy (CBT) program with and without peer support to usual care as a non-pharmaceutical option for pain management in people living with sickle cell disease. CBT is delivered through an innovative digital app that is accessed on a mobile device with one group receiving self-guided CBT and the other receiving CBT plus peer support. The PRESENCE program is comprised of strong community partnerships that provide the peer support component of the intervention.

PI_NAMEs: COLVIN, ALICIA ;JONASSAINT, CHARLES RICHARD (contact);RADOVIC-STAKIC, ANA

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;adolescent health outcomes;Advocate;Age;Anxiety;Behavioral;behavioral health;Black race;Caring;Chronic;chronic pain;Clinical;clinical research site;Cognitive;Cognitive Therapy;community organizations;community partners;community partnership;compare effectiveness;coping;cost;daily pain;Data;design;Development;diaries;digital;digital applications;digital intervention;digital treatment;Disparity;E-learning;Education;Educational process of instructing;Effectiveness;effectiveness evaluation;Emergency department visit;emerging adult;Empathy;Enrollment;evidence base;Exercise;experience;Exposure to;Family member;Focus Groups;Future;General Population;handheld mobile device;healing;health care service utilization;Healthcare Systems;Hospitalization;human centered design;implicit bias;improved;Individual;Infrastructure;innovation;internalized stigma;Intervention;Learning Skill;Libraries;Lived experience;meetings;Mental Depression;Mental Health;Minority Groups;Moods;Multicenter Trials;National Center for Advancing Translational Sciences;non-opioid analgesic;Opioid;opioid use;Outcome;Pain;Pain intensity;Pain interference;Pain management;pain outcome;pain reduction;pain symptom;Parents;Participant;patient engagement;Patients;peer;peer coaching;peer support;personalized approach;personalized learning;Persons;Phase;Population;preference;prescription opioid;primary outcome;programs;Provider;psychologic;psychological outcomes;psychological symptom;psychosocial;racial bias;Randomized;randomized trial;Randomized, Controlled Trials;Reporting;Research Design;Resources;Running;secondary outcome;Secondary pain;Secure;Sickle Cell;Sickle Cell Anemia;Site;social stigma;Stress;stressor;support network;Symptoms;Technology;telephone based;Testing;Text;Therapeutic Intervention;Therapy trial;Training;transition to adulthood;treatment as usual;treatment group;uptake;video chat;virtual delivery;Voice;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: CENTRE FOR ADDICTION AND MENTAL HEALTH

ORG_STATE: ON

PHR: PROJECT NARRATIVE This study will determine whether regular cannabis consumers can effectively self-titrate the THC doses of high- potency cannabis concentrates and characterize the acute subjective, cognitive, physiological and pharmacokinetic effects of a range of THC potencies that have been associated with public health harms, such as cannabis use disorder and accidental injury. This experimental evidence will inform policy decisions on the need to decrease access and/or prevent initiation of high-THC products and implement information or education campaigns to increase awareness on the risks of using high potency products.

PI_NAMEs: RUEDA, SERGIO  (contact);TANG, VICTOR MARK

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Accidental Injury;Accidents;Acute;addiction;addiction liability;American;Attention;Awareness;Behavioral;Biological;Blood;Blood Pressure;Canada;Cannabis;Cardiovascular system;Cognitive;commercialization;Consumption;Creativeness;Cross-Over Trials;Data;Data Collection;Dose;Double-Blind Method;Drug Kinetics;Education;Environment;Event;experimental study;Female;Flowers;Formulation;Health;Heart Rate;high risk;Home;Impaired cognition;Impairment;Industry;Inhalation;Intake;Intoxication;Laboratories;laboratory experiment;Legal;Link;Liquid substance;Literature;male;marijuana legalization;marijuana use;marijuana use disorder;marijuana user;Marketing;Mental Health;Outcome;Participant;Patient Self-Report;Pharmaceutical Preparations;Physiological;Policies;prevent;primary outcome;Process;Psychomotor Performance;Psychotic Disorders;Public Health;Randomized;Randomized, Controlled Trials;Reaction;Regulation;Reporting;Research;Research Personnel;response;Risk;Scientist;secondary outcome;sex;Sex Differences;Short-Term Memory;Speed;Testing;Tetrahydrocannabinol;THC concentration;THC exposure;Titrations;Translating;US State;vaping;virtual

PROJECT_TITLE: THC titration of high-potency cannabis concentrates: A randomized crossover trial

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Postpartum hemorrhage is a common and significant contributor to maternal morbidity, with many complications arising from acute hypovolemia and end-organ damage from subsequent hypoxia. This project will study a digital health solution using a machine learning-based prediction model to identify those at high risk for hemorrhage and then apply a proactive management algorithm (via a clinical decision support tool) to decrease the prevalence of anemia before delivery. This project will demonstrate how applying prediction models at the point of care in obstetrics can directly address the increasing maternal morbidity and mortality rates, which remain a public health priority.

PI_NAMEs: CLAPP, MARK ALLEN (contact)

PROGRAM_OFFICER_NAME: LOMOTAN, EDWIN A

PROJECT_TITLE: An AI-Directed CDS Tool to Reduce Iron Deficiency Anemia in Pregnancy: A Randomized Controlled Trial (AID-IDA Trial)

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE  This Exploratory/Developmental Research Grant proposal seeks to advance the state of the art in diagnostic pediatric retinal imaging by developing a novel, auto-aligning hand-held optical coherence tomography and optical coherence tomography angiography probe capable of routine and repeatable high- quality imaging of infants and children. This probe will find application for diagnostic assessment of pediatric retinal diseases such as retinopathy of prematurity, a leading cause of childhood blindness in the US and worldwide.

PI_NAMEs: CHEN, XI ;DHALLA, AL-HAFEEZ ZAHIR (contact);KUO, ANTHONY NANLIN

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 3-Dimensional;Adoption;Adult;Angiography;Anterior;Applications Grants;Biological Markers;Blindness;Blood Vessels;Child;Childhood;clinical care;Compensation;Computer software;Cross-Sectional Studies;Data;data streams;design;Development;Diagnostic;diagnostic tool;Dimensions;Disease;Exhibits;experience;experimental study;Eye;Face;follow-up;Fundus photography;gaze;Goals;handheld equipment;Health;Human;Image;imaging capabilities;Imaging Device;in vivo;Individual;Infant;invention;Knowledge;Lateral;light weight;Mental Depression;Methods;Motion;Nature;Neurologic;new technology;novel;Ophthalmology;Ophthalmoscopy;Optical Coherence Tomography;Optics;Outcome;Oxygen;Participant;Patients;Performance;Pilot Projects;point of care;portability;Process;Pupil;Reproducibility;Research;Research Project Grants;Retina;Retinal Diseases;retinal imaging;Retinopathy of Prematurity;Robot;Robotics;Sampling;screening;Severities;skills;software development;Speed;Stress;Structure;success;System;Systems Development;Techniques;Technology;Thick;Time;United States National Institutes of Health;Visualization;volunteer

PROJECT_TITLE: Auto-aligning hand-held OCT and OCTA for pediatric applications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD)

ORG_DEPT: CHEMISTRY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Laser scanning microscopy is the standard technique for imaging at depth in thick, scattering tissue. However, further scaling of imaging performance is limited by tissue heating. To circumvent this limit, this project seeks to develop new detection modalities based on nonlinear amplification in optical fibers to improve signal-to-noise ratio, imaging speed, and depth penetration for common techniques including optical coherence tomography, confocal, and multiphoton microscopy; thereby representing a new scaling axis for information capacity.

PI_NAMEs: DEMAS, JEFFREY DAKIN (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TITLE: New detection paradigms for laser-scanning microscopy leveraging fiber optical amplifiers


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Hematology;Infectious Diseases;Microbiome;Pediatric;Regenerative Medicine;Sepsis;Transplantation

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Oral mucositis and bloodstream infections remain as a serious complication in hematopoietic cell transplant (HCT) recipients. The focus of this project is to understand the oral microbial community changes during the development and progression of OM and BSI in HCT recipients, and to define the bloodstream microbial profile in this cohort to determine if the oral cavity is the likely source of bloodstream infections. The results of these studies will inform future preventive and therapeutic strategies to reduce OM and BSI burden in this high-risk patient population.

PI_NAMEs: LEE, KYULIM  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Adult;Agreement;Antibiotics;Bacteremia;Bacteria;Bacterial Translocation;bioinformatics tool;Biological Assay;Biology;Blood;Blood Circulation;Blood specimen;Cessation of life;Chemotherapy and/or radiation;Child;Childhood;Chronic;cohort;Complication;Coupled;curative treatments;Data;Death Rate;Dental Hygiene;Development;diagnosis standard;Diagnostic;Disease;DNA;effective therapy;Foundations;fungus;Future;Global Change;Goals;graft failure;Growth;Health;healthcare burden;Hematopoietic Stem Cell Transplantation;High Prevalence;high risk;Incidence;Infection;infection burden;Injury;Intervention;Investigation;Knowledge;Lesion;Link;Longitudinal Studies;Maintenance;Malignant - descriptor;Methods;Microbe;microbial;microbial community;microbial signature;Morbidity - disease rate;Mucositis;Mucous Membrane;Non-Malignant;Oral;Oral cavity;oral microbial community;oral microbiome;oral mucositis;oral streptococci;Organism;Pain;Pathogenesis;patient population;Patients;Pediatric Hospitals;photobiomodulation;Pilot Projects;Population;Predisposition;preservation;Preventive;prognostic;prophylactic;Protocols documentation;Reporting;Research;Resolution;Role;Sample Size;Sampling;secondary infection;Sepsis;Severities;Site;Source;Streptococcus Viridans Group;Testing;Therapeutic;Time;Tongue;tool;Transplant Recipients;Work

PROJECT_TITLE: Investigating the oral microbiome in hematopoietic cell transplants

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 JC (11)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Candida albicans is among the most significant human fungal pathogens. We recently discovered new genetic determinants of its infection ability. Our studies will extend that discovery to define new mechanisms that contribute to infection and pathogenic interaction.

PI_NAMEs: MITCHELL, AARON P (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Biological Assay;Candida albicans;candidate identification;cell injury;cell type;Cells;Defect;Deletion Mutation;Expression Profiling;Gene Deletion;gene function;gene product;Gene Targeting;Genes;Genetic;Genetic Determinism;Goals;Growth;Human;Hyphae;Infection;Mediating;Mediator;Microbial Biofilms;Modeling;mucosal biofilms;mutant;novel;oropharyngeal thrush;overexpression;overexpression analysis;Partner in relationship;pathogenic fungus;Pathogenicity;Phenotype;Repression;Role;Structure;Testing;trait;Transcription Coactivator;transcription factor;Virulence;Yeasts

PROJECT_TITLE: Roles of C. albicans white-opaque regulators in biofilm and virulence

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Gene Therapy;Genetics;Orphan Drug;Osteogenesis Imperfecta;Pediatric;Rare Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Narrative  Osteogenesis imperfecta (OI) is the most common skeletal rare disease accompanied by bone fragility disease, with an incidence of approximately 1 in 15,000 worldwide and 25,000–50,000 in the US. This proposal will develop and test precision gene editing strategies to repair OI mutations including type I collagen gene mutations, using bone-targeting recombinant adeno-associated virus (rAAV).

PI_NAMEs: SATO, TADATOSHI  (contact);SHIM, JAE-HYUCK

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Address;adeno-associated viral vector;alternative treatment;Amish;Animal Model;Animals;autosomal dominant mutation;base editing;Biochemical;Biological;Biology;bone;bone cell;bone fragility;bone mass;Bone Pain;bone quality;bone strength;Bone Transplantation;bone turnover;Capsid;Cell Line;Cell Therapy;COL1A1 gene;COL1A2 gene;Collagen;Collagen Type I;CRISPR/Cas technology;deep sequencing;design;Disease;DNA;DNA Double Strand Break;DNA Repair;DNA Single Strand Break;Effectiveness;Endonuclease I;Eukaryota;Fracture;gene correction;Gene Expression;Gene Mutation;gene therapy;gene-editing approach;Genes;genome editing;genome-wide;Genomic DNA;Genomics;Growth;Hereditary Disease;Homing;Immune;improved;In Vitro;in vivo;Incidence;innovation;Joint Laxity;Laboratories;long bone;Mediating;Mesenchymal Stem Cells;Messenger RNA;microCT;Minor;mouse model;Mus;Muscle;Mutation;mutation correction;Nature;Nonhomologous DNA End Joining;nuclease;Nucleotides;Osteogenesis Imperfecta;osteogenic;Pathway interactions;Patients;Peptides;Pharmacotherapy;Phenotype;Physiologic calcification;polypeptide;pre-clinical;preclinical trial;Predisposition;prime editing;Process;Production;Property;Proteins;Rare Diseases;Recombinant adeno-associated virus (rAAV);Recombinant DNA;Recurrence;repaired;Reporting;Resolution;Risk;Roentgen Rays;safety assessment;scoliosis;Serotyping;Site;skeletal;skeletal disorder;skeletal tissue;spine bone structure;Structural Protein;success;Symptoms;System;Testing;therapeutic effectiveness;therapeutic gene;therapeutic genome editing;Tissues;Trans-Splicing;Transgenes;Transplantation;Trauma;Treatment Efficacy;vector

PROJECT_TITLE: Precision Gene Editing on Osteogenesis Imperfecta

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The social motivation theory of autism posits that reduced motivation to interact with people and decreased pleasure derived from social interactions may derail typical social development and contribute to the emergence of social communication deficits in autism spectrum disorder (ASD). The objectives of this proposal are to investigate relations between (i) neural responses to social rewards, measured via electroencephalography, (ii) a blood-derived composite marker of systemic inflammation, and (iii) ASD symptoms and quality of life. This project will provide a deeper understanding of relations between neural responses to social rewards, immune functioning, and symptom expression in ASD and has the potential to contribute to the development of EEG-based measures that may be suitable endpoints in future mechanistic trials investigating novel ASD interventions targeting inflammatory processes.

PI_NAMEs: DICHTER, GABRIEL S (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Acute-Phase Proteins;adult with autism spectrum disorder;Affect;Anhedonia;Anti-Inflammatory Agents;Antibodies;Attenuated;autism spectrum disorder;autism symptoms;autistic;autistic children;Autoimmune Diseases;Behavior;Blood;Brain;brain circuitry;brain dysfunction;Brain region;C-reactive protein;Child;Childhood;Companions;cytokine;Data;Desire for food;Development;Disease;disorder risk;early pregnancy;Electroencephalography;Etiology;Exhibits;Exposure to;Fatigue;forging;Future;Goals;Grant;Immune;immune function;Immunotherapy;Impairment;Individual;individuals with autism spectrum disorder;Infection;Inflammation;Inflammatory;Inflammatory Response;Interleukin-6;Intervention;Left;Measures;Mothers;Motivation;neural;Neurodevelopmental Disorder;neuroinflammation;novel;offspring;Participant;Pathogenesis;Peripheral;Persons;Play;pleasure;Positron-Emission Tomography;Poverty;Process;Proteins;Quality of life;recruit;Research;response;reward anticipation;reward circuitry;reward processing;Rewards;Risk;Role;Sampling;Severities;social;social communication;social communication impairment;Social Development;Social Environment;Social Interaction;social skills;Stimulus;Symptoms;systemic inflammatory response;theories;Tracer;Withdrawal

PROJECT_TITLE: Immune Functioning and Reward Processing in Autism

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Osteoarthritis (OA) is a debilitating, degenerative joint disease for which there is no cure or effective therapy. A persistent challenge with OA drug candidates is achieving adequate joint bioavailability and retention with minimal systemic toxicity. This project will explore a drug delivery strategy for targeting OA joints after an intravenous injection, thereby advancing therapeutic options for long-term management of OA.

PI_NAMEs: KEAN, THOMAS J.;SHARMA, BLANKA  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Affect;Animal Model;anterior cruciate ligament rupture;arthropathies;Artificial nanoparticles;Bacteriophages;Biodistribution;Biological Availability;Biological Products;Cartilage;Circulation;Clinical;Contralateral;Degenerative polyarthritis;Development;Disease;Dose;drug candidate;Drug Carriers;Drug Delivery Systems;Drug Targeting;effective therapy;Engineering;ex vivo imaging;Flow Cytometry;fluorescence imaging;fluorophore;Foundations;Glycolic-Lactic Acid Polyester;Goals;high reward;high risk;Histology;Home;Human Resources;human tissue;Image;image guided;imaging modality;Imaging Techniques;in vivo;Infection;Injections;Intra-Articular Injections;Intravenous;intravenous administration;intravenous injection;iron oxide;Joints;Knee Injuries;Knee Osteoarthritis;Label;Libraries;Magnetism;Methods;Modeling;Motivation;mouse model;Mus;nanoparticle;nanoparticle delivery;nanoparticle drug;novel therapeutic intervention;optical imaging;Optics;Pain;particle;Patients;Peptide Synthesis;Peptides;Phage Display;Pharmaceutical Preparations;Phenotype;Physiological;pre-clinical;Process;Property;protein aminoacid sequence;Research;Risk;Route;Site;Solid Neoplasm;System;systemic toxicity;targeted delivery;Technology;Therapeutic;therapeutic target;Time;tissue injury;Tissues;Tracer;Traumatic Arthropathy;validation studies;Work

PROJECT_TITLE: Identification and application of targeting peptides for systemic nanoparticle delivery to osteoarthritic joints

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Narrative The proposed research will create a bacterial vector to deliver oncolytic viruses directly into hepatocellular carcinoma. This therapeutic strategy will induce immunogenic cell death, activate immune cell infiltration and generate antitumor immunity. Triggering immune responses with engineered bacteria and oncolytic viruses will create an immune therapy that is effective in tumors that are resistant to immune checkpoint inhibitors.

PI_NAMEs: FORBES, NEIL S. (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Abscopal effect;Address;anti-tumor immune response;antiviral immunity;Bacteria;bacterial vector;Bacteriophages;Biological;Blood;Bystander Effect;cancer cell;Cancer Etiology;Cancerous;Capsid;carcinogenesis;Cause of Death;CD8-Positive T-Lymphocytes;Cell Death;Cell Death Induction;Cell Nucleus;Cells;Clinical;Couples;cytokine;Cytolysis;Cytoplasm;delivery vehicle;Dendritic Cells;Deposition;DNA;Engineering;Environment;experimental study;Focal Infection;Foundations;Generations;Genes;Genetic Transcription;Genome;Goals;homologous recombination;Human;Immune;immune activation;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immune system;immunogenic cell death;Immunotherapy;Infection;Infiltration;Inflammatory;Intravenous;intravenous injection;Invaded;Location;Macrophage;Malignant Neoplasms;Measures;Mediating;Melanoma;Memory;microbial;Modeling;Molecular;Mus;Natural Killer Cells;neoplastic cell;neutralizing antibody;Nude Mice;Oncolytic;oncolytic virotherapy;Oncolytic viruses;Organ;particle;Parvovirus;Pattern;Plasma;Plasmids;preservation;prevent;Primary carcinoma of the liver cells;Process;Production;Proteins;Research;Resistance;Safety;Salmonella;Solid Neoplasm;success;Surgical Replantation;System;T cell infiltration;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Therapeutic Index;Tissues;Translating;treatment response;tumor;Tumor Antigens;Tumor Immunity;tumor specificity;Tumor Volume;Vacuole;Viral;viral DNA;Viral Genome;Viral Load result;Virion;Virus;Virus Diseases

PROJECT_TITLE: Salmonella as a vector for delivery of oncolytic viruses to hepatocellular carcinoma

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Primary Health Care;Social Determinants of Health

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Addressing disparities in global mental health care access requires structured outcomes-focused measurement to ensure efficient use of resources and effective and equitable service delivery. Existing mental health services access measures are limited in their ability to measure the impact of services interventions on patient- and population- outcomes, and ultimately their effectiveness in reducing mental health disparities. We propose to develop and pilot a service-level access measurement system using existing data that is culturally responsive, appropriate to local resources, and can guide resource distribution within integrated mental health care systems and, ultimately, improve mental health care access in global settings.

PI_NAMEs: CRUZ-CAMPOS, VICTOR ORLANDO;LEVEY, ELIZABETH JANE;PROM DE ILLANES, MARIA CATHERINE (contact)

PROGRAM_OFFICER_NAME: CUBILLOS, LEONARDO

PROJECT_TERMS: acceptability and feasibility;access disparities;Address;Administrator;Award;care delivery;Caring;collaborative care;Communities;community advisory board;community based participatory research;Data;Data Collection;Data Management Resources;Decision Making;Development;Diagnosis;Disparity;Effectiveness;Ensure;Equity;evidence base;Failure;feasibility trial;Feedback;Focus Groups;Future;gaps in access;Geography;Goals;Health;health care availability;health care service;health data;health disparity;Health Personnel;Health Services Accessibility;Health Services Research;Healthcare;Healthcare Systems;HIV;Hospitals;implementation measures;Improve Access;improved;Individual;innovation;integrated care;Intervention;Interview;Link;low and middle-income countries;Measurement;Measures;Mental disorders;Mental Health;Mental Health Services;Methods;Mission;Modeling;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Mental Health;Needs Assessment;Outcome;Patient-Focused Outcomes;Patients;Peru;Peruvian;Population;Population-Based Registry;post implementation;Primary Care;primary care clinic;programs;Provider;Public Health;Registries;Reporting;Research;Resource Allocation;resource guides;Resources;routine care;Rural;scale up;screening;service delivery;Service delivery model;service intervention;Services;Strategic Planning;Structure;Surveys;System;tool;Training;Translating;World Health Organization;years lived with disability

PROJECT_TITLE: Developing measures to improve access to integrated mental health care services in under-resourced global settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (04)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Infant Mortality;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Sleep Research;Sudden Infant Death Syndrome

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Our research strongly implicates defects in the life-sustaining brainstem serotonin system in a major subset of the Sudden Infant Death Syndrome (SIDS), a major cause of death in the first year of life for which there is no known cause. Here we test the hypothesis, directly in SIDS tissue and serum, that abnormalities in two microRNAs and their gene targets hypothesized to relate, directly and indirectly, to abnormalities in serotonin function, exist in the medulla of SIDS infants in a cell-specific fashion, and can be utilized as biomarkers of brain pathology. Data generated will support future research examining the implications of these changes through animal models related to SIDS.

PI_NAMEs: HAYNES, ROBIN LYNN (contact)

PROGRAM_OFFICER_NAME: SANTOS SCHMIDT, AUGUSTO FREDERICO

PROJECT_TERMS: Affect;allograft inflammatory factor-1;Animal Model;Area;Astrocytes;Back to Sleep;Biological;Biological Markers;Biology;Brain;Brain Pathology;Brain Stem;Cause of Death;Cells;Central Nervous System;Cessation of life;comparison control;Computer software;CPE-binding protein;CREB1 gene;Cyclic Nucleotides;Data;Databases;Defect;Development;differential expression;Disease;Funding;Gene Targeting;Genes;Glial Fibrillary Acidic Protein;Goals;high risk infant;Human;In Situ;In Situ Hybridization;Incidence;Infant;Infant Mortality;Inflammation;Inflammatory Response;interest;Investigation;Laboratories;Life;Live Birth;Machine Learning;Messenger RNA;Metabolism;Methodology;Microglia;MicroRNAs;Minor;miRNA expression profiling;Molecular;National Institute of Child Health and Human Development;Neurobiology;Neurons;Neurotransmitters;novel;novel therapeutic intervention;Pathogenesis;Pathology;Pathway interactions;Play;postneonatal mortality;potential biomarker;Prevalence;Prevention;Process;protein expression;Proteins;Regulation;Reporting;Research;Risk Factors;Role;Serotonergic System;Serotonin;Serum;Small RNA;Specificity;stressor;Sudden infant death syndrome;System;Techniques;Testing;therapeutic target;Tissues;TPH2;transcriptome sequencing;United States

PROJECT_TITLE: Brainstem microRNA dysregulation in the pathogenesis of sudden infant death syndrome (SIDS)

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative The objective of this proof of concept study is to advance medication development for alcohol use disorder by testing whether diclofenac, a non-steroidal anti-inflammatory drug, can inhibit the enzyme Kynurenine 3-monooxygenase (KMO) in humans. Inhibition of this enzyme in rodents reduces alcohol, cocaine, nicotine, and THC administration, but no KMO inhibitors are available in humans. Testing new medications, with novel pharmacological mechanisms, is a research priority for NIAAA.

PI_NAMEs: ROCHE, DANIEL  (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: addiction;Affect;Agonist;alcohol abuse therapy;alcohol behavior;Alcohol consumption;alcohol craving;alcohol cue;alcohol effect;alcohol exposure;alcohol seeking behavior;alcohol use disorder;Alcohols;alpha-bungarotoxin receptor;Analgesic and Antipyretic;Animals;antagonist;Anti-Inflammatory Agents;Anticonvulsants;Attenuated;Behavior;behavior test;Bipolar Disorder;Blood;Brain;Cannabinoids;Chronic;Cocaine;cocaine seeking;cognitive function;cognitive performance;cognitive testing;Complex;Convulsants;craving;Cross-Over Studies;cue reactivity;Cues;Development;Diclofenac;Disease;Dopamine;dosage;Dose;Double-Blind Method;drug development;effective therapy;Emotional;Enzyme Inhibition;Enzymes;extracellular;FDA approved;Functional disorder;Gatekeeping;Human;improved;Individual;inhibitor;interest;Kynurenic Acid;Kynurenine;Kynurenine 3-monooxygenase;Major Depressive Disorder;Measures;Mental disorders;Metabolic;Molecular Target;N-Methyl-D-Aspartate Receptors;National Institute on Alcohol Abuse and Alcoholism;negative mood;Neurobiology;neuroprotection;neurotoxic;Nicotine;nicotine self-administration;Nicotinic Receptors;Non-Steroidal Anti-Inflammatory Agents;novel;novel strategies;Nucleus Accumbens;Pathologic Processes;Pathology;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;Physiological Processes;Placebo Control;Placebos;Plasma;pre-clinical;preference;Production;Property;Prostaglandin Inhibition;Proxy;Quinolinic Acid;Randomized;receptor;Relapse;Reporting;Research Priority;Rodent;Schizophrenia;screening;Self Administration;Severities;side effect;substance misuse;symptomatology;Testing;Tissues;Up-Regulation

PROJECT_TITLE: Proof of concept: diclofenac as a KMO inhibitor in AUD

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: AI

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative To serve as a catalyst to generate knowledge and translate it into successful strategies to prevent, treat and cure HIV infection, we organized the Einstein/Rockefeller/CUNY-Center for AIDS Research (ERC-CFAR). The ERC- CFAR brings together a highly synergistic partnership of complementary resources by linking a strong basic and clinical research institution `treating a large patient base of people with HIV (Einstein), a globally pre-eminent basic science institution (Rockefeller), and a strong public health/implementation science institution (CUNY) to energize and mobilize our complementary basic, translational, clinical, epidemiologic, behavioral, and implementation research programs to attain our shared goal of Ending the HIV Epidemic.

PI_NAMEs: GOLDSTEIN, HARRIS  (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Adherence;Affinity;AIDS prevention;antiretroviral therapy;Area;Award;base;Basic Science;Behavioral;Behavioral Research;Behavioral Sciences;behavioral study;Biological Markers;catalyst;chimeric antigen receptor T cells;Cities;Clinical;clinical center;Clinical Research;Clinical Sciences;Collaborations;college;Communities;Community Health;community partners;Country;County;Data;Development;Diagnosis;economic disparity;Eligibility Determination;Epidemic;Epidemiology;epidemiology study;Failure;Financial Support;forging;Funding;Future;Goals;Grant;Health;Health system;HIV;HIV diagnosis;HIV Infections;HIV/AIDS;Immunologic Adjuvants;Implant;implementation research;implementation science;implementation strategy;Improve Access;improved;Infection;Inflammatory;Infrastructure;innovation;Institution;Interdisciplinary Study;Investments;Knowledge;Lead;Leadership;Link;Location;Logistics;Medicine;member;Mental disorders;Mental Health;Mentors;Modality;National Institute of Mental Health;neurochemistry;neutralizing antibody;New York;New York City;next generation;novel;novel therapeutics;Outcome;pandemic disease;Paper;Pathogenesis;Patients;Persons;Play;Population;pre-exposure prophylaxis;prevent;Prevention;preventive intervention;Process;Productivity;programs;Prophylactic treatment;Public Health;Public Health Schools;Publications;Publishing;recruit;Research;Research Personnel;Research Priority;Resources;response;Role;scale up;Services;Site;social disparities;Strategic Planning;success;synergism;Technology;therapy adherence;Translating;Translational Research;transmission process;United States;United States National Institutes of Health;Universities;uptake;Vacuum;Viral;Viremia;Vision;working group

PROJECT_TITLE: ERC Einstein-Rockefeller-CUNY Center for AIDS research


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ACCRA

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: COLLEGE OF HEALTH SCIENCES, UNIVERSITY OF GHANA

PHR: Public Health Relevance: An. stephensi poses a major threat to the current malaria control and elimination efforts in Ghana. There are huge gaps in data on the extent of spread, densities and bionomics of this invasive vector. The results of these studies will provide evidence for the development of effective control interventions against these invasive species to help in the control and elimination of Malaria in Ghana

PI_NAMEs: AFRANE, YAW ASARE (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TITLE: Invasive Anopheles stephensi in Ghana: Sampling Tools and Vector Population Dynamics

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Genetics

ORG_NAME: CREIGHTON UNIVERSITY

PHR: PROJECT NARRATIVE V(D)J recombination is a DNA rearrangement process that is responsible for generating a diverse population of B and T cells that together provide highly specific immunity to pathogenic microorganisms. The proposed research will determine if a protein called VprBP(DCAF1) stabilizes the histone-lysine N-methyltransferase Enhancer of zeste homolog 2 (Ezh2) in primary B cells, and through VprBP’s association with the RAG1 protein that initiates V(D)J recombination, modulates Ezh2 methyltransferase activity on histone H3 to regulate gene expression and immune repertoire in B cells. This work will not only illuminate a novel role for VprBP in regulating V(D)J recombination, but will also reveal how VprBP(DCAF1) and Ezh2 collaborate to support transcriptional programs during early B cell development.

PI_NAMEs: SWANSON, PATRICK C. (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Adaptive Immune System;adaptive immunity;Antigen Receptors;B-Cell Development;B-Lymphocytes;Benign;Binding;Binding Proteins;Binding Sites;Cell Lineage;Cleavage Under Targets and Release Using Nuclease;Collaborations;Complex;Cullin Proteins;Defect;Dependence;Development;Distal;DNA Double Strand Break;Double Strand Break Repair;Ectoderm;Embryo;endonuclease;enhancer binding protein;Enhancers;Epitopes;Exons;experimental study;Foundations;Gene Expression;Gene Family;Gene Proteins;Gene Rearrangement;Gene Silencing;Genes;Genetic Recombination;Genetic Transcription;genome-wide;Genomic Instability;Heavy-Chain Immunoglobulins;Histone H3;Histone-Lysine N-Methyltransferase;Histones;Homologous Gene;humoral immunity deficiency;IGH@ gene cluster;Immune;Immunity;Immunoglobulin D;Immunoglobulin Genes;Immunoglobulins;Immunologic Deficiency Syndromes;Impairment;innovation;interest;Knock-out;Knockout Mice;Length;Lymphocyte;Lysine;Malignant Neoplasms;Mediating;methyl group;Methylation;Methyltransferase;microbial;microorganism;Mus;Mutation;Nonhomologous DNA End Joining;novel;Organism;Pathogenicity;Pattern;Phenotype;Phosphotransferases;Play;Polycomb;Population Heterogeneity;Process;programs;Protein Deficiency;protein expression;Proteins;receptor;Receptor Gene;recruit;Research;RNA;Role;Site;small molecule;Sorting;Surface Antigens;T-Lymphocyte;Testing;transcriptome;ubiquitin-protein ligase;V(D)J Recombination;Work

PROJECT_TITLE: Role of a RAG1-DCAF1(VprBP)-Ezh2 axis in B cell development

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Immunization;Immunotherapy;Nanotechnology;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Vaccine Related

ORG_DEPT: NEUROSCIENCES

PHR: This project aims to develop a novel treatment for an uncurable childhood brain tumor. In this sense, this project will contribute to the applica�on of knowledge to enhance health, lengthen life, and reduce illness and disability among this pediatric popula�on.

PI_NAMEs: HOH, BRIAN LIM;OKUN, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Adult;animal imaging;Animal Model;Animals;Antigens;Canis familiaris;Childhood;Childhood Brain Neoplasm;Clinical Trials;combat;Development;Diagnosis;Diffuse intrinsic pontine glioma;diffuse midline glioma;disability;Disease;effective therapy;Glioma;Gliosis;H3 K27M mutation;Health;Human;Hydrocephalus;Immune;immune cell infiltrate;immunogenicity;Immunotherapeutic agent;Knowledge;Lesion;Life;lipid nanoparticle;Long-Term Survivors;Magnetic Resonance Imaging;Malignant Neoplasms;Modality;Modeling;mouse model;Mus;Names;nanoparticle;novel;Patients;pre-clinical;radiological imaging;Refractory;response;RNA;RNA vaccine;Safety;Secondary to;targeted treatment;Techniques;Therapeutic;therapeutic nanoparticles;tumor;Tumor Burden;Tumor-Derived;Vaccines;Visualization

PROJECT_TITLE: H3K27M as a Target for RNA-nanoparticles in the Treatment of Diffuse Intrinsic Pontine Glioma


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE The Emory CFAR will contribute to ending the HIV epidemic by accelerating the highest caliber translational research — fostering team science, equity, and multidirectional stakeholder engagement. We will strive to build community trust in research through the intentional inclusion of key stakeholders at all stages of the research pipeline. We will achieve our goals by providing innovative services, tools, expertise, and access to state-of- the-art equipment through an Administrative Core, a Developmental Core, five Science Cores (Biostatistics and Bioinformatics; Clinical Research; Prevention and Implementation Sciences; Systems Immunology; and Virology and Molecular Biomarkers); and two Scientific Working Groups (SWGs) - Health Equity and Next Generation Therapeutics.

PI_NAMEs: CHAHROUDI, ANN M;DEL RIO, CARLOS  (contact);KELLEY, COLLEEN F

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acceleration;access disparities;Acquired Immunodeficiency Syndrome;African American;Appointment;Area;Award;Basic Science;bench to bedside;Bioinformatics;Biometry;Caliber;Clinical Research;Collaborations;Communities;community advisory board;community building;community engagement;County;Coupled;Development;Doctor of Philosophy;Epidemic;Equipment;Equity;Fostering;Funding;Geographic Locations;Geography;Goals;Grant;health care availability;health equity;health equity promotion;Hispanic;Historically Black Colleges and Universities;HIV;Home;Immunology;implementation science;improved;innovation;Internet;Investments;Latinx;life span;Location;member;minority investigator;Mission;molecular marker;Morehouse School of Medicine;next generation;novel therapeutics;Peer Review;Personal Satisfaction;Persons;Phase;Population;pre-clinical research;Prevention;Public Health;Publications;recruit;Research;Research Personnel;Research Priority;Risk;Role;Science;Services;System;Teacher Professional Development;tool;Training;Translating;Translational Research;Trust;Underrepresented Minority;United States National Institutes of Health;Universities;virology;Woman;working group

PROJECT_TITLE: Center for AIDS Research at Emory University


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health