NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE The goal of this project is to advance our understanding of how new neurons form in the adult brain, and why this process is defective in the context of Alzheimer’s disease. The discoveries made through this work may lead to therapies to treat Alzheimer’s or other neurodegenerative diseases.

PI_NAMEs: WEBB, ASHLEY E (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: 3xTg-AD mouse;Ablation;Address;Adult;Affect;Age;age acceleration;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Area;ATAC-seq;Atrophic;Autopsy;Brain;Brain Injuries;candidate identification;Cell Cycle;Cell Differentiation process;Cell division;Cell Nucleus;Cells;Chromatin;cognitive performance;Communities;CRISPR screen;CRISPR/Cas technology;Cytoplasmic Granules;Data;dentate gyrus;Disease;entorhinal cortex;Epigenetic Process;epigenomic profiling;epigenomics;excitatory neuron;experience;functional genomics;Functional impairment;Future;Gene Expression;gene network;Genes;Genetic Transcription;Genomic approach;Goals;healthy aging;Hippocampus;Human;Human Pathology;human tissue;Image;Impaired cognition;Impairment;improved;Individual;interest;Intervention;Investigation;Knowledge;Late Onset Alzheimer Disease;Learning;Link;Memory;Memory Loss;Metabolic;metabolomics;Methods;Mitochondria;mood regulation;mouse model;multiple omics;Nerve Degeneration;nerve stem cell;Neurodegenerative Disorders;neurogenesis;Neurons;Pathway interactions;Population;prevent;Process;ratiometric;Resolution;Risk Factors;Rodent;Sampling;self-renewal;single nucleus RNA-sequencing;Source;stem cell function;stem cell population;therapy development;Time;transcriptomic profiling;transcriptomics;Work

PROJECT_TITLE: Investigation of impaired neural stem cell activation in Alzheimer's Disease


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE/RELEVANCE Many blinding disorders affect millions of people of all ages This UCSF Center Core Grant for Vision Research application is to facilitate studies of the structure, development and function of the visual system in health and disease, with the aim of preventing, mitigating or curing such disorders, or the restoration of lost vision or slow vision loss, through the application of the most sophisticated available techniques.

PI_NAMEs: ULLIAN, ERIK M (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Affect;Age;Algorithmic Analysis;Biometry;Blindness;Brightfield Microscopy;Center Core Grants;Collaborations;Communities;Computer Assisted;Computer Hardware;Computers;Core Grant;Custom;Darkness;Data;data acquisition;Data Analyses;Data Storage and Retrieval;design;Development;Disease;Educational process of instructing;Electrophysiology (science);empowerment;Equipment;Equipment Design;Eye;Fluorescein Angiography;Fluorescence;Frozen Sections;Funding;Fundus photography;Grant;Health;High Performance Computing;Histology;Image Analysis;Immunohistochemistry;in vivo;Injections;innovation;Knowledge;light microscopy;Maintenance;manufacture;Methods;Microscope;Microscopy;Modality;Morphology;Multiphoton Fluorescence Microscopy;ocular imaging;Optical Coherence Tomography;Paraffin Embedding;Persons;Phase;Photography;Photomicrography;Plastic Embedding;prevent;Principal Investigator;Privatization;Production;Productivity;programs;prototype;Publications;Research;Research Personnel;Research Project Grants;Resources;restoration;Rodent;Scientist;Services;skills;Stains;Structure;Techniques;Testing;tool;Training and Education;transcriptome sequencing;United States National Institutes of Health;Vision;Vision research;vision science;Visual;Visual System

PROJECT_TITLE: P30 - Core Grant for Vision Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (07)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PHR: PROJECT NARRATIVE Dr. Ullian will oversee all Core grant-related activities including distribution of Core information to all Vision scientists, preparing progress reports, and all fiscal matters.

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Biomedical Imaging;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

PHR: PROJECT NARRATIVE The Image Analysis and Graphics Core established over 15 years ago continues to provide expertise and training to utilize image analysis software, expertise for the optimal and efficient design of presentation material for scientific meetings and to design and produce professional high-quality graphic illustrations and diagrams. New to this Core is high level analysis expertise and customized software for computerized analysis and quantification of cellular profiles in various eye tissues.

PI_NAMEs: LAKKARAJU, APARNA  (contact)

PROJECT_TERMS: anterior chamber;Collaborations;Computer Hardware;Computer software;computerized;Core Grant;Cornea;data visualization;design;Eye;high standard;Image;Image Analysis;Image Enhancement;image visualization;lens;Manuscripts;meetings;posters;Production;quantitative imaging;Research;research faculty;Research Personnel;Resource Sharing;Resources;Retina;Scientist;Slide;Tissues;Training;Uvea;Vision;Vision research;Visual

PROJECT_TITLE: Imaging Analysis and Graphics Core


PHR: PROJECT NARRATIVE Morphology Core's objective is to continue providing the instruments and expertise required by: and support needed for performing histological studies, ocular imaging, and functional visual testing, plus the latest imaging technology at a level exceeding the capabilities of any one individual laboratory.

PI_NAMEs: NAIR, KAYARAT SAIDAS  (contact)

PROJECT_TERMS: Clinical;Collaborations;Confocal Microscopy;Consultations;Core Grant;cryostat;Darkness;Effectiveness;Electron Microscopy;Equipment;Evaluation;experience;Eye;Faculty;Fluorescence Microscopy;Histologic;histological studies;Histology;Image;Imaging technology;in vivo;Individual;Injections;instrument;Laboratories;light microscopy;Microscope;Microscopy;Microtome - medical device;Morphology;ocular imaging;Phase;Phenotype;Photomicrography;Research Personnel;Resource Sharing;Resources;Rodent;Scientist;Services;Stains;Techniques;Testing;Tissue Embedding;tissue processing;tool;Training;Vision;Vision research;Vision Tests;Visual

PROJECT_TITLE: Morphology Core


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

PHR: PROJECT NARRATIVE The computer/IT core provides outstanding computer and IT support, programming, and teaching by an experienced technician; as well as a centralized database for collaborative use of validated programs both within UCSF and throughout the vision community.

PI_NAMEs: OU, YVONNE  (contact)

PROJECT_TERMS: Algorithmic Analysis;Algorithms;analysis pipeline;Automation;Brain;central database;Code;Communities;Computer Hardware;Computer software;Computers;Consultations;Core Grant;Custom;Data;data acquisition;Data Analyses;Data Security;Data Storage and Retrieval;Dedications;Educational process of instructing;Electrophysiology (science);Ensure;Equipment;equipment acquisition;experience;Flow Cytometry;High Performance Computing;imaging Segmentation;Information Technology;Infrastructure;Instruction;Journals;laboratory development;Laboratory Research;Maintenance;Minor;Modality;multimodality;Multiphoton Fluorescence Microscopy;Neurons;open source;Outcome;programs;repaired;repository;Research;Research Project Grants;response;Retina;Security;Specialist;Technology;tool;Training;transcriptome sequencing;United States National Institutes of Health;Vision;Vision research;visual stimulus;Visual System

PROJECT_TITLE: Computer/IT Core


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision

PHR: PROJECT NARRATIVE The goal of the RPDC is the education and training of users and empowering them to participate in the manufacturing, construction, maintenance, and upgrading of their unique research equipment designs.

PI_NAMEs: LAMBA, DEEPAK ASHOK (contact)

PROJECT_TERMS: central database;Communities;Consultations;Core Grant;database design;design;empowerment;Equipment;Equipment Design;Goals;Maintenance;manufacture;prototype;Research;Training and Education;Vision;Vision research

PROJECT_TITLE: Rapid-Prototype and Design Core


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Neovascular age-related macular degeneration is a leading cause of blindness in elderly Americans and is currently treated by drugs with limited efficacy and high rates of developing subretinal scar that hinders visual acuity improvement. This project will investigate causal link between the current drug therapy and the scar. More importantly, this project will develop a novel therapy that can alleviate the disease without causing subretinal scar for better efficacy to improve vision.

PI_NAMEs: LI, WEI  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: absorption;Age;American;angiogenesis;Angiogenesis Inhibition;Angiogenesis Inhibitors;Angiogenesis Pathway;Angiogenic Factor;Animal Model;antiangiogenesis therapy;Biological;Blindness;Blood flow;Blood Vessels;Choroidal Neovascularization;Cicatrix;Clinical;Clinical Research;Combined Modality Therapy;Coupled;Data;Disease;Disease remission;Dose;Elderly;Enrollment;Epidemic;Extravasation;Exudative age-related macular degeneration;Fibrosis;Goals;humanized antibody;improved;Inflammation;inhibitor;innovation;Lasers;Leucocytic infiltrate;Link;Macrophage;macula;Mediating;Monoclonal Antibodies;mouse model;Mus;new epidemic;novel;novel therapeutics;old mice;Pathologic;Pathologic Neovascularization;Patients;Pharmaceutical Preparations;Pharmacotherapy;Physiologic Neovascularization;Placebos;receptor;Receptor Signaling;Recovery;Reporting;Resolution;Retina;Role;secretogranin III;Severities;side effect;Signal Pathway;synergism;Testing;thrombospondin 4;Treatment Factor;Treatment Protocols;trend;Validation;Vascular Endothelial Growth Factors;Vascular remodeling;Vision;Visual Acuity

PROJECT_TITLE: Paradoxical role of anti-VEGF therapy in subretinal fibrosis of wet AMD

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Overall Core Project Narrative This NEI Core Center Grant for Vision Research will enhance the capabilities of vision research scientists across multiple departments at UT Southwestern Medical Center (UTSW) by providing technical support, facilities and services that can be shared by investigators. The Core Center will expand experimental capabilities, and result in more cost-effective and rigorous research. The Center will also implement programs to facilitate new research collaborations both within the institution, regionally, and nationally, and create a fertile environment for the development of trainees, junior faculty members, and new vision researchers recruited into the University.

PI_NAMEs: PETROLL, W MATTHEW (contact)

PROJECT_TERMS: Animals;Area;Award;Cells;cellular imaging;Center Core Grants;Collaborations;Contract Services;Core Grant;cost effective;Dependovirus;Development;DNA;Environment;Equipment;experience;Extramural Activities;Eye;Faculty;Fostering;Foundations;Funding;Genes;Goals;graduate student;Grant;improved;in vivo;induced pluripotent stem cell;Institution;interest;Lentivirus;Maintenance;Medical center;Medical Students;member;Microscopy;novel;operation;Organoids;Outcome;Phenotype;Postdoctoral Fellow;Privatization;Production;Productivity;programs;Publications;quantitative imaging;recruit;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Resources;RNA;Scientist;Services;stem cells;Students;System;Technical Expertise;Techniques;Time;Tissues;Training;Universities;Virus;Vision;vision development;Vision research;vision science;Visual System;Work

PROJECT_TITLE: Core Grant for Vision Research


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PROJECT_TERMS: adjudication;Advisory Committees;Animals;Area;Award;Budgets;Cells;Center Core Grants;Collaborations;Committee Members;Contract Services;Core Grant;cost effective;Development;Discipline;Doctor of Philosophy;Ensure;Environment;Equipment;Expenditure;experience;Faculty;flexibility;Foundations;Genes;Goals;graduate student;Grant;Institution;Interdisciplinary Study;Maintenance;Medical Students;meetings;member;Microscopy;new technology;operation;Organoids;Outcome Measure;Participant;Phenotype;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;Principal Investigator;Privatization;Production;Productivity;Publications;Recommendation;Research;Research Personnel;Research Project Grants;Resources;Schedule;Scientific Advances and Accomplishments;Scientist;Services;stem cells;Structure;Students;success;technology/technique;Time;Training;Virus;Vision;Vision research;vision science;Work

PROJECT_TITLE: Admin-Core


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PI_NAMEs: ROBERTSON, DANIELLE M. (contact)

PROJECT_TERMS: adult stem cell;Area;arm;Body Fluids;Calendar;Cell Culture Techniques;Cell Line;Cell Separation;Cells;Collaborations;Communities;Core Grant;Cryopreservation;Data;Data Analyses;Derivation procedure;design;Development;embryonic stem cell;Ensure;Equipment;Experimental Designs;extracellular vesicles;Eye;Flow Cytometry;Fostering;Funding;Generations;Genus Hippocampus;Goals;Grant;high throughput screening;Human;Human body;Individual;induced pluripotent stem cell;Institution;instrument;interest;investigator training;Karyotype determination procedure;Laboratories;Maintenance;Metabolic;Methods;microvesicles;Mouse Embryonic Stem Cells;Mus;Mycoplasma;operation;Organoids;Phenotype;Pilot Projects;Postdoctoral Fellow;programs;Reagent;Records;Reproducibility;Research Activity;Research Personnel;Research Project Grants;Resolution;Resources;Schedule;Services;Spirometry;stem cells;Structure;Students;Technical Expertise;Technology;Testing;testing services;Training;Validation;Vision;Vision research;vision science

PROJECT_TITLE: Stem Cell, Organoid and Cell Phenotyping Module


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: Address;Angiography;animal imaging;Animals;Anterior;behavior test;behavioral response;Cells;cellular imaging;computerized data processing;Confocal Microscopy;Contract Services;Core Grant;cost;cost effective;Data;data acquisition;Data Analyses;Data Collection;Dedications;design;digital;digital imaging;Dimensions;Electroretinography;Equipment;experimental study;Extracellular Matrix;Eye;Fees;Funding;fundus imaging;Future;Goals;Image;Image Analysis;image processing;imaging facilities;imaging software;imaging study;Imaging Techniques;Imaging technology;immunocytochemistry;in vivo;Individual;Institution;investigator training;Label;Laser Scanning Confocal Microscopy;Lasers;Light;Maintenance;microscopic imaging;Microscopy;morphometry;multi-photon;multiphoton microscopy;operation;Ophthalmoscopy;Optical Coherence Tomography;Pathway interactions;Phenotype;Process;quantitative imaging;Records;reflectance confocal microscopy;Research;Research Personnel;Research Project Grants;Resources;response;Scanning;Scientist;Services;slit lamp imaging;Structure;Technology;Testing;Time;tissue processing;Tissues;Training;Vision;Vision research;vision science;visual processing;Visual System;Visualization

PROJECT_TITLE: Microscopy and Animal Phenotyping


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics

PI_NAMEs: PARK, KEVIN KYUNG  (contact)

PROJECT_TERMS: Animals;base editing;biological systems;Biology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Consultations;Core Grant;Custom;Dependovirus;DNA;DNA Maintenance;Documentation;endonuclease;Endotoxins;Epigenetic Process;experimental study;Future;gene editing technology;Gene Expression;Generations;Genes;genome editing;Guide RNA;human disease;imaging platform;In Vitro;in vivo;Individual;Infrastructure;Institution;instrument;instrumentation;knock-down;Lentivirus;Maintenance;Mediating;Modification;Organoids;overexpression;Pathogenesis;Phenotype;plasmid DNA;Plasmids;Point Mutation;Preparation;prime editing;Procedures;Production;promoter;Proteins;Publications;Research;Research Personnel;Resources;RNA;Scientist;Serotyping;Services;Site-Directed Mutagenesis;small hairpin RNA;stem cells;System;Techniques;Technology;Testing;tool;Transcript;Validation;Variant;Viral;Virus;Vision;Vision research;Western Blotting;Work

PROJECT_TITLE: Gene Editing and Virus Production Module


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Research narrative Resilience to perturbations is a fundamental property of biological systems, and the brain’s highly parallel and redundant information processing provides a likely substrate for resilience. This project aims to elucidate principles of modular information processing that produce the brain’s resilience to neuron loss. Understanding these principles is crucial for understanding how brains react to neural degradation in disease.

PI_NAMEs: DRUCKMANN, SHAUL ;LI, NUO  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Area;Behavior;Behavioral;biological systems;Brain;Brain region;Chronic;Code;cognitive ability;cognitive process;Compensation;Computer Models;design;Disease;frontal lobe;Goals;information processing;Information Storage;Learning;Mus;Nerve Degeneration;neural;Neurobiology;neuron loss;Neurons;novel;optogenetics;Population;Process;Property;Reaction;Research;resilience;Shapes;Short-Term Memory;Signal Transduction

PROJECT_TITLE: Dissecting modular and redundant organization of cortical circuits


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Ocular hypertension due to decreased aqueous humor drainage from the trabecular meshwork is a major but a modifiable risk factor for glaucoma, one of the leading causes of blindness worldwide. Based on our promising and novel supporting findings, this proposal will investigate whether dysregulation of the Wnt and other related signaling pathways in response to elevated levels of cell surface proteoglycans (Glypicans) plays an etiological role in inducing ocular hypertension via aberrant stimulation of trabecular meshwork contractile activity, cell adhesive interactions, and barrier activity. These studies are expected to identify the prominent upstream molecular pathways involved in ocular hypertension and support the identification of new molecular targets for the development of efficacious treatments for glaucoma.

PI_NAMEs: RAO, P VASANTHA (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Actins;Actomyosin;Address;Adhesions;Adhesives;Adverse effects;Aqueous Humor;Atrophic;Blindness;Cell Adhesion;Cell surface;cell type;Cells;cellular targeting;Characteristics;Conditioned Culture Media;crosslink;Cytoskeletal Modeling;Cytoskeleton;Data;Detection;Development;Dexamethasone;Drainage procedure;efficacious treatment;Erinaceidae;Etiology;Extracellular Matrix;Eye;Filopodia;Filtration;Gene Targeting;Glaucoma;Glucocorticoids;Glypican;Goals;Growth Factor;Heparan Sulfate Proteoglycan;Homeostasis;Human;Impairment;insight;Kidney;kinase inhibitor;Knockout Mice;Knowledge;mechanotransduction;Mediating;Modeling;modifiable risk;Molecular;Molecular Target;mouse model;Mus;nanobodies;novel;Nuclear;Ocular Hypertension;Optic Nerve;overexpression;Pathologic;Pathway interactions;Patients;pharmacologic;Physiologic Intraocular Pressure;Play;podocyte;Primary Open Angle Glaucoma;Production;Property;Protein Tyrosine Kinase;Proteins;Proteoglycan;Proteome;Proteomics;Recombinants;Regulation;Resistance;response;rho GTP-Binding Proteins;Rho-associated kinase;Risk Factors;Role;Signal Pathway;Signal Transduction;stem;Stress Fibers;Testing;Time;Tissues;Trabecular meshwork structure;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;WNT Signaling Pathway

PROJECT_TITLE: Role of Glypicans in Trabecular Meshwork Function, IOP, and Glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Patient Safety;Prevention

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: NARRATIVE The current approach for peripheral artery disease (PAD) management is to reopen arteries with a “one size fits all” intervention that does not consider the composition of the plaque, which contributes to the high failure rate of the intervention. To solve this problem, we propose a two-pronged approach to improving PAD management utilizing a novel MRI-histology protocol on below-the knee arteries: 1) creating an MRI-based plaque scoring system that predicts intervention success in vivo and 2) using detailed plaque analysis of vessels ex vivo to assess the degree of vessel wall injury resulting from orbital atherectomy in various plaque types and evaluate its potential in reducing dissections in concentric calcium plaques. This will empower clinicians with objective, rational, and personalized approaches that decrease immediate failures and optimize device choice for PAD interventions.

PI_NAMEs: ROY, TRISHA  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Address;Amputation;Anatomy;Angiography;Angioplasty;Arteries;Atherectomy;Balloon Angioplasty;Blood flow;Blood Vessels;Cadaver;calcification;Calcium;Cardiovascular Pathology;Categories;Cessation of life;Chronic;Clinical;clinical decision-making;clinical practice;Collagen;Data;Decision Making;Deposition;Device Safety;Devices;Disease;Disease Management;Dissection;Effectiveness;empowerment;evidence base;Exhibits;experience;Face;Failure;Foundations;Frustration;Future;group intervention;Harvest;hazard;Health Benefit;Healthcare;High Prevalence;high risk;Histologic;Histology;Human;Image;improved;in vivo;Individual;individual patient;Injury;innovation;Intervention;Intervention Trial;Ischemia;Knee;Knowledge;Leg;Lesion;Limb structure;Link;Magnetic Resonance Imaging;Methods;Modeling;Morbidity - disease rate;Morphology;novel;Operative Surgical Procedures;Outcome;Patient imaging;Patient Selection;Patients;Penetration;Performance;Perfusion;Peripheral arterial disease;personalized approach;Pilot Projects;post intervention;Preparation;prevent;Procedures;Process;prospective;Protocols documentation;Qualifying;Radiation;radiologist;Randomized;Research;response;Risk;Safety;Scientist;Sex Differences;skills;Smooth Muscle;statistics;success;Surgeon;Surgical Pathology;System;Testing;Thrombus;treatment optimization;treatment strategy;ultrasound;Vision;Visualization;Work

PROJECT_TITLE: Advancing Endovascular PAD Treatment: Overcoming Critical Knowledge Gaps with MRI-histology

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Overall Project Narrative  The Center for Advanced Imaging Innovation and Research (CAI2R) develops novel imaging techniques and technologies for the improved diagnosis and management of cancer, musculoskeletal disease, neurological disease and other disorders with a profound impact on human health. Leveraging novel magnetic resonance imaging (MRI) and sensor hardware, together with rigorous biophysical modeling and artificial intelligence, we aim to expand biomedical knowledge and improve the care of patients.

PI_NAMEs: SODICKSON, DANIEL K (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Acceleration;Adopted;Adoption;Area;arm;Artificial Intelligence;artificial intelligence method;Beds;Biological Sciences;biomedical imaging;biophysical model;cancer imaging;Caring;Clinical;clinical care;clinical practice;Code;Collaborations;Color;Computer software;convict;Country;Creativeness;Data;data acquisition;data handling;Data Set;data sharing;data streams;deep learning;design;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Doctor of Philosophy;Engineering;experience;flexibility;Future;Health;Human;Image;image reconstruction;Imagination;imaging approach;Imaging Device;imaging scientist;imaging software;Imaging technology;improved;Industrial Product;Industry;industry partner;innovation;Institution;interest;invention;Knowledge;Legal patent;Machine Learning;Magnetic Resonance Imaging;Malignant Neoplasms;Mathematics;Medical Imaging;Methods;millisecond;Mission;Modeling;Modernization;Musculoskeletal Diseases;musculoskeletal imaging;Nervous System Disorder;new technology;next generation;novel;novel imaging technique;open source;open source tool;operation;Patient Care;Patients;Performance;Persons;Philosophy;Physicians;Positron-Emission Tomography;Process;Productivity;Public Health;Publishing;quantitative imaging;Radiation therapy;radio frequency;reconstruction;Research;Research Personnel;Scanning;Scientist;sensor;sensor technology;Services;Site;Standard Model;Structure;System;Techniques;Technology;Technology Assessment;technology development;technology research and development;Testing;Text;Thinking;Time;tool;Training;Translating;Validation;web services;web site;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-D (M1)]


PROJECT_TITLE: CAI2R Administration


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: FENG, LI  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Achievement;Area;Artificial Intelligence;biomedical imaging;Breathing;clinical practice;Collaborations;Complex;Data;data acquisition;Data Set;deep learning model;density;design;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Doctor of Philosophy;Fatty acid glycerol esters;follow-up;Foundations;Funding;Future;Goals;Hybrids;Image;image guided radiation therapy;image reconstruction;Imaging technology;innovation;liver imaging;lung imaging;Machine Learning;Magnetic Resonance Imaging;Maps;Memory;Methods;Mission;Modeling;Monitor;Motion;motion sensor;novel;Pathway interactions;Patient Care;Patients;Physiologic pulse;Preparation;Process;Protocols documentation;Protons;quantitative imaging;Radial;Radiation therapy;rapid technique;real-time images;reconstruction;Research;Research Personnel;Risk;Risk Assessment;Sampling;Scanning;Scheme;sensor;serial imaging;Services;Shapes;Software Tools;Structure;Techniques;Technology;technology research and development;Time;tool;Translating;Translational Research;trend;Variant;Water;Work

PROJECT_TITLE: TR&D 1: Reimagining the Future of Scanning: Intelligent Image Acquisition, Reconstruction and Analysis


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Networking and Information Technology R&D (NITRD)

PI_NAMEs: COLLINS, CHRISTOPHER M (contact)

PROJECT_TERMS: 3-Dimensional;Address;Anatomy;Appearance;Area;artificial intelligence algorithm;Biomedical Engineering;biomedical imaging;Book Chapters;Books;Cardiac;Cephalic;Clinical;clinical practice;Communities;computerized tools;Consumption;cost;Data;Data Set;design;detector;Development;Devices;Disease;Doctor of Philosophy;Elements;Ensure;Evaluation;Evolution;experience;Extramural Activities;flexibility;Focused Ultrasound;Frequencies;Funding;Future;Goals;Grant;Gravitation;Human body;Image;imaging modality;imaging study;Imaging technology;improved;Influentials;innovation;interest;kinematics;Legal patent;Light;Magnetic Resonance Imaging;member;Mission;Modeling;Modernization;Monitor;Motion;motion sensor;Musculoskeletal;musculoskeletal imaging;Nature;novel;novel strategies;Nuclear;Paper;Pathology;Patients;Peer Review;Performance;Philosophy;Posture;Predisposition;Publications;radio frequency;reconstruction;Research;respiratory;risk prediction;Safety;Scanning;sensor;simulation;Speed;Surface;System;Technology;technology research and development;Temperature;Time;tool;training data;Translational Research;ultrasound;user-friendly;Variant;wearable device;Work

PROJECT_TITLE: TR&D 2: Unshackling the Scanners of the Future: From Rigid Control to Flexible Sensor-Rich Navigation


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Machine Learning and Artificial Intelligence;Neurosciences

PI_NAMEs: NOVIKOV, DMITRY S (contact)

PROJECT_TERMS: Accounting;Address;Algorithms;anatomic imaging;Animals;Autopsy;Axon;Basic Science;Biological Markers;biomedical imaging;biophysical model;biophysical properties;Biophysics;Brain;Cell Membrane Permeability;Cell Size;cell type;Classification;Clinic;Clinical;clinical application;clinical care;clinical practice;Clinical Research;clinically relevant;Collaborations;data acquisition;Data Set;data space;data streams;denoising;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;Disease Progression;Doctor of Philosophy;Electron Microscopy;feature extraction;Fiber;Fingerprint;Goals;gray matter;Histology;Human;Image;Imaging Device;Imaging technology;in vivo;innovation;instrument;Leadership;Length;Machine Learning;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Measurement;Measures;Methods;millimeter;Mission;Modeling;Monitor;Monte Carlo Method;Morphologic artifacts;MRI Scans;Nervous System Disorder;Neurites;neurodevelopment;Neurosciences;neurosurgery;normal aging;Pathology;Physics;Physiological;Physiology;Prostate;Protocols documentation;Protons;reconstruction;Relaxation;Research;Research Personnel;Resolution;Sampling;Scanning;Signal Transduction;Specificity;Standard Model;Structure;technology research and development;theories;Time;Tissues;tool;Translating;Translational Research;Translations;Treatment Efficacy;Validation;Water;water diffusion;white matter

PROJECT_TITLE: TR&D 3: Revealing Microstructure: Biophysical Modeling and Validation for Discovery and Clinical Care


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LATTANZI, RICCARDO  (contact)

PROJECT_TERMS: Address;Algorithms;Artificial Intelligence;biomedical imaging;Brain;Clinical;clinical practice;Clinical Protocols;Clinical Research;clinical translation;Collection;Communities;Complement;Computer software;contrast enhanced;Data;data acquisition;data pipeline;Data Set;data tools;data visualization;design;Development;Diffusion;Disease Progression;Doctor of Philosophy;Educational workshop;Ethics;Foundations;Free Will;Funding;Goals;Group Meetings;Human;Image;Imaging Device;Imaging Techniques;Imaging technology;improved;Individual;Industrialization;industry partner;innovation;Interest Group;International;Knee;large-scale imaging data;lectures;machine learning algorithm;machine learning method;Magnetic Resonance Imaging;Mission;MRI Scans;multidimensional data;multidisciplinary;new technology;Online Systems;open source;operation;pandemic disease;Patients;Physicians;Physiologic pulse;Population;prevent;program dissemination;programs;Prostate;prototype;Radial;radiologist;reconstruction;repository;Research;Research Personnel;Scanning;Scientist;self supervised learning;Series;Services;simulation software;Site;Software Framework;Students;success;supervised learning;Techniques;Technology;Testing;Time;tool;Training;Training Activity;training opportunity;Translational Research;translational scientist;Visit;Visualization

PROJECT_TITLE: Training & Dissemination


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH Alzheimer’s disease and related disorders are hallmarked by impaired proteostasis, which facilitates pathologic protein aggregation and causes neuron degeneration. A more detailed understanding of the dysregulation of proteostasis associated with the pathogenesis of Alzheimer’s disease will enable the discovery of new effective and durable therapies. Here, we will employ a strategy that uses novel tools to reliably detect protein AMPylation with increased sensitivity to deliver a fundamental understanding of how changes in FICD- mediated protein AMPylation affect proteostasis in the brain of Alzheimer’s disease patients and predispose neurologically unaffected controls to a neurologically degenerative state; this is a prerequisite to therapeutically target this enzyme to improve health and fitness of the aging human brain.

PI_NAMEs: TRUTTMANN, MATTHIAS CHRISTOF (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Administrative Supplement;Affect;age related;Aging;alpha synuclein;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid beta-Protein;assay development;Biochemistry;Biological Models;Brain;brain cell;Brain region;brain tissue;Caenorhabditis elegans;Cell Nucleus;cell type;Communities;Cytoplasm;Data;Dedications;Dementia;Enzymes;fitness;Goals;Health;Human;Human Cell Line;Immunofluorescence Immunologic;improved;In Vitro;in vivo;Link;Maps;Mediating;Meta-Analysis;mouse model;Nematoda;Nerve Degeneration;Neurologic;Neurons;novel;Nuclear;parent project;Pathogenesis;Pathogenicity;Pathologic;Physiological;polyglutamine;programs;protein aggregation;protein purification;Proteins;proteostasis;proteostasis loss;Public Health;Publications;Regulation;Research;Role;Stains;Systems Biology;therapeutic target;tool;tool development;Western Blotting;Work

PROJECT_TITLE: Conserved regulation of proteostasis by post-translational protein AMPylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ORG_CITY: BETHESDA

ORG_NAME: U.S. NATIONAL EYE INSTITUTE

ORG_STATE: MD

PHR: PROJECT NARRATIVE This research proposal aims to define the proteomic and functional profile of peripheral sensitization in human pluripotent stem cell (hPSC)-derived sensory neurons. We will employ a human cellular model of pain and integrative strategies encompassing stem cell technology, electrophysiology, proximity labeling, and ribosomal and protein sequencing methods to examine for alterations in key molecular signaling pathways and functional expression of cell surface proteins associated with peripheral sensitization. The overall goal of this research is to identify potential biomarker signatures and candidate genes that can be therapeutically leveraged to prevent or alleviate pain.

PI_NAMEs: CASTELLANO, DAVID DEASIS (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Affect;Afferent Neurons;biomarker signature;Biotinylation;Bradykinin;Brefeldin A;Candidate Disease Gene;Cell model;Cell surface;Cell Surface Proteins;Cells;chronic pain;Cycloheximide;Detection;Development;differentiation protocol;Dinoprostone;effective therapy;Electrophysiology (science);Etiology;Exhibits;Exocytosis Inhibition;Gene Expression;Generations;Genes;Genetic Transcription;Goals;Height;Histamine;Human;human pluripotent stem cell;Hypersensitivity;Inflammation;Inflammation Mediators;Ion Channel;Label;Mass Spectrum Analysis;Membrane;Methods;Modeling;Molecular;Monitor;multi-electrode arrays;neuronal excitability;Neurons;Nociception;Nociceptors;novel;Pain;pain model;patch clamp;Peptide Sequence Determination;Peripheral;pharmacologic;Phenocopy;Physiology;Play;potential biomarker;prevent;Process;Protein Biosynthesis;protein expression;Protein Inhibition;Protein Synthesis Inhibition;protein transport;Proteome;proteomic signature;Proteomics;Protocols documentation;rate of change;Regulation;Reproducibility;Research;Research Proposals;response;ribosome profiling;Ribosomes;Rodent;Role;Serotonin;Signal Pathway;Spinal Ganglia;stem cell technology;Stimulus;Surface;Therapeutic;trafficking;transcriptomics;Translational Regulation;Translations;transmission process

PROJECT_TITLE: Proteomic and functional profiling of peripheral sensitization in human pluripotent stem cell-derived sensory neurons

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (MK)]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Site-one protease (S1P) is a protease within the human secretory pathway that activates signaling pathways for lipogenesis, ER stress, and lysosomal biogenesis; and is also exploited by some viruses. This research proposal aims to understand how a recently discovered co-factor protein called SPRING or C12ORF49 activates S1P so that it can proteolyze its substrates. A mechanistic understanding of site-one protease function and its activation by SPRING may lead to new molecular approaches to target this critical enzyme and ameliorate metabolic disorders like fatty liver disease.

PI_NAMEs: KOBER, DANIEL LUKE (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Animals;Back;Behavior;Binding;Binding Proteins;Binding Sites;Biochemical;Biochemistry and Cellular Biology;Biogenesis;Biological;biological adaptation to stress;Biological Assay;Biophysics;Cells;Cellular biology;Cholesterol;Cholesterol Homeostasis;cofactor;Complex;Cryoelectron Microscopy;Data;endoplasmic reticulum stress;Ensure;Enzyme Precursors;Enzymes;Event;experimental study;Family;fatty liver disease;Future;gene interaction;Generations;Genes;Genetic Transcription;glycosylation;Golgi Apparatus;Human;Impairment;inhibitor;insight;Intervention;Length;Link;lipid biosynthesis;Lysosomes;Mammalian Cell;Measures;Mediating;Membrane;Metabolic Diseases;Molecular;Molecular Conformation;Mutagenesis;mutant;Mutation;Names;nuclease;Pathway interactions;Peptide Hydrolases;Peptide Library;Peptides;Polysaccharides;programs;protease So;Protein Precursors;Proteins;Proteolysis;reconstruction;Regulatory Element;Research;Research Proposals;Resolution;Response Elements;Route;Signal Pathway;Signal Transduction;Site;site-1 protease;Sterols;structural biology;Structure;Substrate Specificity;Surface;System;Testing;transcription factor;Translating;Up-Regulation;uptake;Virus;Work

PROJECT_TITLE: Structural and mechanistic basis for the maturation of site-one protease in the secretory pathway

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The cardiovascular health of young women, especially women of color and low-income women, is poor during and after pregnancy, but we know little about the reasons for this and what to do about it. Although it is well accepted that a healthy diet is one of the most important behaviors people can target to prevent cardiovascular disease, research is needed on diet among young pregnant and postpartum women. Our work will guide the design of programs to alter diet to improve young women's cardiometabolic health and reduce its inequalities.

PI_NAMEs: BODNAR, LISA M (contact);NAIMI, ASHLEY ISAAC

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Adult;adverse pregnancy outcome;Age;Agreement;attributable risk;Behavior;Black race;Body mass index;burden of illness;Cardiac health;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cessation of life;Characteristics;child bearing;Chronic Disease;clinically actionable;Communities;Conceptions;cost effective;cost efficient;Data;deprivation;design;Development;Diet;Diet Modification;dietary;dietary guidelines;Dietary Intervention;Dietary Practices;disorder prevention;Disparity;Drops;Ethnic Origin;Future;Gestational Diabetes;Goals;good diet;Health;Hypertension;improved;Individual;Inequality;innovation;interest;Knowledge;Life Style;long-standing disparities;Low income;Medical;Metabolic syndrome;middle age;Minority Groups;Modeling;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Nutrient;Nutritional Study;older adult;Outcome;Participant;Persons;Physiology;Play;Policy Maker;post pregnancy;Postpartum Period;postpartum weight;Postpartum Women;Pregnancy;pregnancy hypertension;pregnant;Pregnant Women;Premature Birth;prepregnancy;prevent;Prevention;primary outcome;Primary Prevention;programs;Provider;Public Health;Race;Research;Research Personnel;Resources;Risk;Risk Factors;Role;Sampling;secondary analysis;Shapes;social health determinants;Socioeconomic Status;socioeconomics;Strategic Planning;Strategic vision;Time;United States National Institutes of Health;Visit;Vulnerable Populations;Woman;women of color;Work;young woman

PROJECT_TITLE: Identifying optimal dietary patterns for postpartum cardiovascular disease prevention

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: COLLEGE STATION

ORG_DEPT: CHEMISTRY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: PROJECT NARRATIVE  The major goal of the project is to develop potent small molecule and peptidic inhibitors and proteolysis- targeting chimeras for the ENL YEATS domain that plays a significant role in leukemogenesis of cells with the mixed-lineage leukemia (MLL) gene rearrangement. These molecules can be potentially used to treat MLL- rearranged leukemia that has a high fatality rate in patients. Therefore, the proposed research is highly relevant to public health and NIH’s mission in promoting health and combating diseases.

PI_NAMEs: LIU, WENSHE RAY (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: 11q23;Acetylation;Active Sites;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Amino Acids;animal efficacy;antileukemic agent;Bacteriophages;Binding;Biological Availability;bioluminescence imaging;Blood;Bone Marrow;cell killing;Cell Line;Cells;Characteristics;Chemicals;Chemistry;Chimeric Proteins;Coupling;design;Development;Disease;drug candidate;drug development;Drug Kinetics;efficacy study;efficacy testing;Epigenetic Process;Evolution;Exhibits;Fatality rate;Fostering;Funding;Gene Expression;Gene Rearrangement;Genes;Goals;Growth;Half-Life;Health Promotion;high throughput screening;Histone Acetylation;Histones;Hour;Human;improved;In Vitro;in vivo;in vivo evaluation;indexing;inhibitor;innovative technologies;Investigational Drugs;Length;leukemia;leukemia treatment;Leukemic Cell;leukemogenesis;Libraries;Ligands;Liver Microsomes;Lysine;Maintenance;Malignant Neoplasms;Medical;Metabolic;Methylation;Mission;Mixed-Lineage Leukemia;MLL gene;MLLT3 gene;Modality;Monitor;Mus;Mutation;neoplastic cell;Oral;Oral Administration;Patients;Permeability;Phage Display;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetic characteristic;pharmacokinetics and pharmacodynamics;Plasma;Play;Prognosis;Property;Protac;protein degradation;Protein Degradation Induction;Protein Family;Proteins;Public Health;Publishing;Quality of life;Reader;Research;Role;small molecule;small molecule inhibitor;Structure;Structure-Activity Relationship;Survival Rate;System;targeted treatment;Techniques;Technology;Therapeutic;therapy development;Time;Toxic effect;tumor;tumor progression;United States National Institutes of Health;Xenograft procedure

PROJECT_TITLE: A Multiplatform Approach to Develop ENL-Targeting Molecules as Drug Candidates for Acute Myeloid Leukemia

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Childhood Obesity;Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE American Indian youth have the highest prevalence of obesity of all ethnic groups in the United States. Health behaviors can modify obesity risk and associated morbidity. The goal is to develop and test community-led, family-focused and culturally-responsive intervention that supports American Indian youth in achieving healthy lifestyle behavior change.

PI_NAMEs: HINGLE, MELANIE DANIELA (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: Address;Adolescent;adolescent health;Adopted;Adoption;adult obesity;adverse childhood events;aged;American Indian community;American Indians;Apache Tribe;Attention;Behavior;behavior change;Body mass index;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Caregivers;Child;Child Rearing;Chronic Disease;Communities;Community Actions;community collaboration;community led intervention;Consumption;Coping Skills;cost;culturally appropriate intervention;design;Diabetes Mellitus;disorder prevention;Ensure;Equilibrium;ethnic disparity;Ethnic Population;Faculty;Family;Family Relationship;fasting glucose;Foundations;fruits and vegetables;Glycosylated hemoglobin A;Goals;Health;Health behavior;health disparity;Healthy Eating;healthy lifestyle;High Prevalence;Home;Home environment;Hypertension;improved;Individual;Intake;Intervention;intervention delivery;Intervention Studies;Knowledge acquisition;Life;Life Cycle Stages;Lipids;Malignant Neoplasms;Measures;Mental Health;Metabolic Diseases;Mind-Body Intervention;Modeling;Morbid Obesity;Morbidity - disease rate;novel;Obesity;obesity prevention;obesity risk;Outcome;Parents;Participant;Pascua Yaqui;Persons;Physical activity;post intervention;Poverty;preventive intervention;primary outcome;programs;Pueblo Race;racial disparity;Research;Risk;Risk Factors;Risk Reduction;Schools;secondary outcome;skills;skills training;social determinants;socioeconomic disparity;Sodium Chloride;Specificity;Strenuous Exercise;Stress;Stroke;success;Testing;Time;Trauma;tribal community;tribal Nation;Tribes;Trust;United States;Weight;Well in self;Work;Yavapai;Youth

PROJECT_TITLE: Achieving American Indian Youth Energy and Mental Health Balance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-F(51)R]


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Uncontrolled asthma in school-aged children is a significant public health problem. Low-SES Latino children are at increased risk for uncontrolled asthma compared to non-Latino white children, and psychosocial stress is an unaddressed factor in this disparity. Therefore, the proposed intervention targets coping with stress as a way to reduce risk for uncontrolled asthma in low-SES Latino children.

PI_NAMEs: RODRIGUEZ, ERIN M. (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: 13 year old;2 arm randomized control trial;acceptability and feasibility;Address;Affect;Age;arm;Asthma;asthma exacerbation;Behavior;Belief;bilingualism;Buffers;Child;Childhood Asthma;clinical decision-making;Cognitive;Communities;compare effectiveness;Control Groups;coping;Coping Skills;cost;cost effective;depressive symptoms;Disparity;disparity reduction;Education;Educational Curriculum;effective therapy;Effectiveness;effectiveness testing;Elements;Emergency department visit;Empirical Research;Enrollment;evidence base;experience;Family;Financial Hardship;follow-up;functional outcomes;Goals;Health;health disparity;Hospitalization;Household;Immigration;implementation trial;improved;insight;Intervention;Knowledge;Latino;Link;low socioeconomic status;Mediating;Mediator;Moods;Outcome;Parents;Pathway interactions;Patients;Pharmaceutical Preparations;Pilot Projects;Population;Populations at Risk;post intervention;Poverty;Primary Care;primary care clinic;Problem behavior;Process;programs;psychobiologic;psychosocial;Psychosocial Stress;Public Health;pulmonary function;Quality of life;Randomized;Records;recruit;Reporting;Research;Risk;Risk Reduction;Role;Sampling;School-Age Population;Schools;Self Management;Site;social health determinants;Societies;Spanish;Spirometry;Stress;Stress and Coping;stressor;Symptoms;Testing;translational research program;Underserved Population;Work;Youth

PROJECT_TITLE: A Coping Skills Intervention for Low-SES Latino Families of Children with Asthma

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The HARMONY study will test the effects of a culturally-tailored mindfulness self-management intervention on sustained improvements in healthy eating and exercise through improved mindful stress management, self- regulation, and self-efficacy in overweight African American women at risk for chronic cardiometabolic illness.

PI_NAMEs: GAYLORD, SUSAN ;GISCOMBE, CHERYL L (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: 18 year old;actigraphy;Address;Adherence;Adopted;Adult;Affect;African American Women;allostatic load;American;arm;attentional control;Behavioral;Biological Markers;Body fat;Body mass index;C-reactive protein;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;caregiving;Chronic;Chronic disability;Chronic Disease;Chronic stress;Cognitive;Communities;community advisory board;Community Health;community setting;cytokine;Death Rate;depressive symptoms;design;Diabetes Mellitus;Diet;dietary;Disparity;disparity reduction;Distress;Eating;Eating Behavior;Educational process of instructing;Emotional;Ethnic Population;Exercise;experience;Exposure to;feasibility research;fruits and vegetables;Gender;Goals;Health;health disparity;Healthy Eating;healthy lifestyle;High Risk Woman;implementation facilitation;improved;Inflammatory;Informal Social Control;Intake;Intervention;intervention effect;Life;lifestyle intervention;loved ones;Measures;Mediating;Mediator;men;mindfulness;mindfulness intervention;Mindfulness Training;nutrition;nutrition education;Obesity;Outcome;Overweight;Participant;Patient Self-Report;perceived stress;physical inactivity;Physiology;Posture;Psychological Stress;Quality of life;Questionnaires;Race;racial population;Randomized;Randomized, Controlled Trials;Research;resilience;response;Risk;Risk Assessment;Risk Factors;Risk Reduction;Self Care;Self Efficacy;Self Management;self reliance;social culture;sociodemographic group;Stress;stress management;stress reduction;stressor;Stroke;success;Testing;United States National Institutes of Health;Waist-Hip Ratio;White Women;Woman;women versus men;Women's Group;Work

PROJECT_TITLE: THE HARMONY Study - A culturally-relevant, randomized-controlled, stress management intervention to reduce cardiometabolic risk in African American women.

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: BRONX

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FORDHAM UNIVERSITY

PHR: Project Narrative Both ethnic/racial minority and college student populations suffer from sleep disparities, including short sleep duration, poor sleep quality, and irregular sleep schedules. Yet, there is scant longitudinal research exploring the mechanisms and pathways through which race-related sleep disparities impact health and academic outcomes concurrently and over time among diverse college students. The current study employs an innovative combination of daily diaries and actigraphy, biannual surveys, annual dried blood spot biomarker samples, and anthropometric assessments to investigate the impact of sociodemographic and environmental stress on race-related sleep disparities from the first through senior year of college; informing researchers, public health experts, and educators about the social-biomedical mechanisms through which stress impacts ethnic/racial minority health and academic disparities.

PI_NAMEs: YIP, TIFFANY  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: actigraphy;Address;Adult;Affect;African American student;Anxiety;Asian;Behavior Therapy;biobehavior;Biological Markers;Black race;Blood;Buffers;Chronic;cognitive function;college;critical developmental period;Data;Development;diaries;Disparity;Dryness;Environment;environmental stressor;Ethnic Origin;Ethnic Population;evidence base;executive function;flexibility;Generations;Goals;Health;health determinants;health disparity;health equity;Health Policy;Heart Diseases;high school;High School Student;Hypertension;Inflammation;Inflammatory;innovation;Intervention;Investigation;Latinx;Length;life span;Link;Longitudinal Studies;Maintenance;Malignant Neoplasms;Measures;Mediating;Mental Depression;Meta-Analysis;minority health;minority student;Modeling;novel;Obesity;Outcome;outcome disparities;Pathway interactions;peer;Physiological;poor sleep;Population;pressure;Prevalence;protective effect;Public Health;Race;racial disparity;racial identity;racial minority;racism;Reduce health disparities;Reporting;Research;Research Personnel;Risk;Risk Behaviors;Sampling;Schedule;Science;Sleep;Sleep disturbances;sleep pattern;sleep quality;social;social determinants;Social Environment;Social Sciences;sociocultural determinant;sociodemographics;Socioeconomic Status;socioeconomics;Spottings;Stress;stressor;Students;success;Surveys;telomere;Time;United States;university student;urban setting;Vulnerable Populations;young adult

PROJECT_TITLE: Social-Environmental Predictors of Sleep Disparities During the Transition toCollege


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Microbiome;Neurosciences;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH This study will provide new information about how social stressors contribute to obesity among Mexican and Filipino American women. Specifically, it tests the hypothesis that stressors lead to eating behaviors and dietary changes and that alter the brain-gut-microbiome axis. A better understanding of the role of how stress “gets under the skin” to contribute to alterations in the brain and gut microbial metabolites in obesity, could lead to novel therapeutic strategies tailored to treat altered ingestive behaviors and obesity.

PI_NAMEs: CHURCH, ARPANA  (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Accelerometer;Address;advanced analytics;Affect;Affective;Anatomy;Aromatic Amino Acids;Asian;Autonomic nervous system;Bacteroidetes;Behavior;Behavioral;Biology;Blood specimen;blood-brain barrier crossing;Body mass index;Brain;brain magnetic resonance imaging;Brain region;Calories;Cells;Chronic Disease;Clinical;Cognitive;Communication;Communities;Complex;craving;Cues;Data;data integration;Desire for food;Diabetes Mellitus;Diet;Diet Records;dietary;Dietary Practices;Disease;Disinhibition;Dopamine;dysbiosis;Eating;Eating Behavior;Enrollment;Environmental Impact;Environmental Risk Factor;environmental stressor;ethnic difference;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;Exposure to;Feces;Feeding behaviors;Filipino American;Firmicutes;Food;food consumption;Functional disorder;Gene Expression Profile;gut microbes;gut microbiome;gut microbiota;gut-brain axis;Health;health disparity;Heart Diseases;Hour;Hypothalamic structure;Immune;immune activation;Inequality;Intervention;Knowledge;Kynurenine;Latinx;Lead;learning strategy;machine learning method;Magnetic Resonance Imaging;Measures;Mediating;metabolomics;Metagenomics;Mexican;Mexican Americans;microbial;microbiome;microbiome alteration;MRI Scans;multiple data sources;neuroimaging;Neurologic;neurotransmission;novel;novel therapeutic intervention;Obesity;obesity development;obesity risk;obesogenic;Overweight;Participant;Pathway interactions;Pattern;Phenotype;Physical activity;Play;Positioning Attribute;Process;Public Health;Questionnaires;Race;recruit;Research;Research Support;response;Rewards;Risk Factors;Role;Sampling;Serum;sex;Shotguns;Signal Pathway;Signal Transduction;Skin;social culture;Social Discrimination;social influence;Social isolation;social stressor;stool sample;Stress;stressor;Subgroup;supervised learning;Surveys;System;Systems Biology;Techniques;Testing;Tryptophan;unsupervised learning;waist circumference;Woman

PROJECT_TITLE: Social Isolation and Discrimination as Stressors Influencing Brain-Gut Microbiome Alterations among Filipino and Mexican American


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed RCMI Coordinating Center will serve as a national resource to advance the science of minority health and health disparities through coordination of intellectual exchange and collaborative interactions that enhance research capacity and competitiveness of the RCMI U54 Centers.

PI_NAMEs: OFILI, ELIZABETH O. (contact);SARPONG, DANIEL F;TCHOUNWOU, PAUL B.

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Acceleration;Award;Basic Science;Behavioral Research;Behavioral Sciences;Biological;Biomedical Research;career development;central database;Clinical and Translational Science Awards;clinical infrastructure;Clinical Research;Clinical Sciences;Collaborations;Common Data Element;Communication;community engaged approach;community engagement;community organizations;community partners;Consultations;Core Facility;culturally appropriate intervention;Development;Educational workshop;effective intervention;Equipment;ethnic disparity;Evaluation;expectation;experience;Fostering;Funding;geographic disparity;Grant;health disparity;implementation facilitation;improved;Information Technology;Infrastructure;Institution;inter-institutional;Marketing;Measures;meetings;Mentors;Methodology;minority health;minority health disparity;Minority-Serving Institution;Modeling;Monitor;National Center for Advancing Translational Sciences;National Institute of General Medical Sciences;National Institute on Minority Health and Health Disparities;Online Systems;outreach;participant retention;Patient Recruitments;Performance;Pilot Projects;Principal Investigator;Productivity;Program Evaluation;programs;Research;Research Activity;Research Design;Research Infrastructure;Research Personnel;research study;Resources;Science;Scientist;searchable database;social health determinants;success;symposium;Translational Research;Visit

PROJECT_TITLE: Research Centers in Minority Institutions (RCMI) Coordinating Center


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Orphan Drug;Precision Medicine;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative The proposed research is relevant to public health because discovery of therapy for APOL1-associated kidney disease will reduce the incidence of end stage kidney disease and associated costs and mortality, and mitigate racial disparities in kidney health in the U.S., which is within the mission of NIDDK.

PI_NAMEs: OLABISI, OPEYEMI AYODEJI (contact)

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Address;African;African American;African American population;Albumins;American;Apolipoproteins;Caring;causal variant;Cells;Chronic Kidney Failure;Church;Clinical;clinical predictors;clinical trial in a dish;Clinical Trials;Code;Colorectal Cancer;Communities;community engaged approach;community engagement;cost;Creatinine;Creativeness;Data;Development;Diagnosis;Disease;Disparity;disparity reduction;effective therapy;efficacy study;efficacy testing;End stage renal failure;Enrollment;European;Failure;Financial cost;Focal and Segmental Glomerulosclerosis;Future;Genes;Genotype;glomerular filtration;Glomerular Filtration Rate;Goals;Health;health disparity;Hemoglobin;high risk;Human;Hypertension;in vivo;Incidence;Individual;individualized medicine;induced pluripotent stem cell;inhibitor;Injury;Injury to Kidney;innovation;Interferon Type II;JAK1 gene;JAK2 gene;Kidney;kidney biopsy;Kidney Diseases;Laboratories;Malaria;Malignant Breast Neoplasm;men;Mission;Modeling;mortality;Mutation;Names;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Immunity;Nephrology;novel;Outcome;Participant;Pathway interactions;patient derived induced pluripotent stem cells;patient oriented research;Patients;personalized medicine;personalized therapeutic;Persons;Pharmaceutical Preparations;Phase;phase III trial;Phosphotransferases;Placebos;podocyte;Population;Potassium;Prediction of Response to Therapy;predictive tools;primary endpoint;programs;protective effect;Proteins;Proteinuria;Public Health;racial disparity;Randomized;randomized trial;randomized, clinical trials;Research;response;Risk;risk variant;Safety;safety assessment;screening;Sickle Hemoglobin;Signal Transduction;targeted treatment;Testing;theories;Therapeutic Trials;tool;Translational Research;treatment response;Trypanosoma;urinary;Validation;Variant;Woman;years of life lost

PROJECT_TITLE: JAK-STAT Inhibition to Reduce Racial Disparities in Kidney Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE In the U.S., the childhood obesity epidemic disproportionally impacts minority communities, particularly Hispanic children. Minority populations face multiple psychosocial stressors at the individual, household and community level that are associated with increased obesity risk. This research will establish the biological embedment of early-life adversity at the individual, household and community level on epigenetic marks, with the goal of developing early-life biomarkers of risk.

PI_NAMEs: CARDENAS, ANDRES ;DEARDORFF, JULIANNA  (contact)

PROGRAM_OFFICER_NAME: MUNIZ ORTIZ, JORGE GERARDO

PROJECT_TERMS: 14 year old;18 year old;accelerated epigenetic aging;Acceleration;Address;Adolescence;Affect;Age;Aging;aging biomarker;aging clocks;Biological;biological adaptation to stress;Biological Markers;Biological Testing;Birth;Blood;California;Candidate Disease Gene;Cell Differentiation process;Cell Lineage;Cellular Structures;Child;Childhood;Chronic;cohort;Communities;Cues;Data;Development;Disease;DNA Markers;DNA Methylation;early childhood;early detection biomarkers;early life adversity;Embryonic Development;Environment;Epidemic;epigenetic aging;epigenetic clock;epigenetic marker;Epigenetic Process;epigenome;epigenomics;Exposure to;Face;fetal;Fetal Development;Future;Gene Expression;Genes;Genetic;Genotype;Goals;Health;health assessment;health disparity;Hispanic;Household;Immune system;Individual;Inflammatory;Latinx;Life;Longitudinal Studies;Low income;machine learning method;Measurement;Measures;Mediating;Mediation;Mediator;Mendelian randomization;Metabolic;Methods;Methylation;methylation biomarker;methylation pattern;methylome;Mexican Americans;Minority;minority communities;Minority Groups;Modeling;Morbidity - disease rate;Mothers;Not Hispanic or Latino;novel;Obesity;Obesity Epidemic;obesity in children;obesity risk;offspring;Overweight;Pathway interactions;Pattern;Phase;Physiological;postnatal;postnatal period;Predisposition;prenatal;prenatal influence;prenatal testing;Prevalence;programs;prospective;Psychosocial Factor;psychosocial stressors;Public Health;racial disparity;rate of aging;Reporting;Research;response;Risk;Risk Factors;Role;Salinas Valley;Sampling;social;social adversity;Social Environment;Statistical Methods;stressor;Testing;Tissues;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Variant;Writing

PROJECT_TITLE: Common and Distinct Influences of Prenatal and Postnatal Early-Life Adversity on Epigenomic Trajectories in Mexican American Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-G(55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Diabetes;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Nutrition;Obesity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Latinos have been disproportionally represented among COVID-19 cases and deaths in the United States. Latinos with diabetes are at particularly high risk given that diabetes is associated with poor outcomes including death. In addition, Latinos have been dramatically impacted by sequelae of the pandemic including a steep rise in household food insecurity, which leads to worsening glycemic control for those with diabetes. Effective multilevel interventions that can be remotely delivered are urgently needed for Latinos with diabetes to mitigate disparities due to COVID-19.

PI_NAMEs: ROSAS, LISA GOLDMAN (contact);TESTER, JUNE M

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: 2019-nCoV;Address;Adolescent;Adopted;Adult;Agriculture;arm;bean;Behavior;Behavior Therapy;behavioral outcome;California;Calories;Cessation of life;Classification;Clinic;Communities;community partners;Control Groups;Coping Skills;cost;County;COVID-19;COVID-19 complications;COVID-19 disparity;COVID-19 mortality;COVID-19 pandemic;COVID-19 stress;depressive symptoms;design;diabetes control;Diabetes Mellitus;Diet;dietary;Dietary Fiber;disparity reduction;Dissemination and Implementation;Distress;Dose;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness trial;Ethnic Population;experience;Fabaceae;Family member;Farm;Fiber;Food;food insecurity;Future;Gender;glycemic control;Glycosylated hemoglobin A;Goals;good diet;Government;Government Programs;Health Food;high risk;Home;Household;hybrid type 1 trial;Immigration;improved;Individual;Intake;Intervention;Interview;Latino;Latino Population;Leadership;Life;Life Style;lifestyle intervention;Location;Loneliness;Measures;Mediator;member;Methods;Neighborhood Health Center;neighborhood safety;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;Outcome;Overweight;pandemic disease;Participant;Patients;Persons;Phase;preservation;Primary Care;primary outcome;programs;Provider;psychosocial;psychosocial outcome;racial population;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Recurrence;remote delivery;Risk Factors;Rotation;safety net;screening;Seasons;secondary outcome;social;Social Distance;Social support;Testing;Time;treatment as usual;United States;Vegetables;Waiting Lists

PROJECT_TITLE: The ADELANTE Trial: Testing a multi-level approach for improving household food insecurity and glycemic control among Latinos with diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(58)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE The proposed Stage 3 efficacy study aims to inform health policy by testing a novel intervention that directly reduces the racial income gap by providing a universal basic income (UBI), which is intended to promote and protect Black men's health through the influx of capital and subsequent increases in personal agency and social connections. We hypothesize that (1) providing UBI of $500 per month for six months will result in increased healthcare utilization among chronically-ill, older and aging, low-income Black men; and (2) the effect of UBI will depend on whether an individual has a recent history of incarceration, such that no incarceration history combined with UBI will demonstrate the best study outcomes. Empirical research examining UBI among older Black men and its capacity to overturn structural racism are lacking in the extant literature—much of the health disparities research intended to inform health and economic policy originated from limited perspectives of older and aging Black men—Dr. W.E.B. Du Bois said in The Souls of Black Folk that for Black people, “discouragement is an unwritten word”; this study draws on that inspiration as it ultimately seeks to fundamentally overturn the economic oppression and brutality that has defined the Black experience for generations.

PI_NAMEs: MONTGOMERY, BROOKE E.E. (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Accounting;Address;Affect;African American;Aging;Area;behavioral health;black men;Black Populations;Black race;Breathing;Capital;Caring;Chronic;Chronic Disease;Chronically Ill;Communities;Community Health;Complex;Correctional Institutions;design;Discrimination;Disease;Economic Policy;Economics;Education;efficacy study;Emotional;Empirical Research;Ensure;Epidemiology;experience;Family;Financial Hardship;Generations;Geography;Health;Health behavior;health care availability;health care service;health care service utilization;health difference;Health Disparities Research;Health Policy;health service use;Healthcare Systems;HIV;Imprisonment;Income;Individual;Intervention;Justice;Literature;Low income;low socioeconomic status;male health;Marketing;men;Methods;Minority Groups;novel;Outcome Study;Overdose;Perception;Pharmaceutical Preparations;physical conditioning;Police;Policies;population health;Poverty;protective factors;Race;racial disparity;racial health disparity;Racial Segregation;recidivism;Recording of previous events;Recurrence;reincarceration;Research;residence;Resources;Risk;Role;segregation;social;Structural Racism;Testing;Time;transmission process;Trauma;United States;Wages;Writing

PROJECT_TITLE: Universal basic income and structural racism in the US South: Differences in health service utilization between older African American men with and without experiences of recent incarceration


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: PROJECT NARRATIVE This study will evaluate the effects of a parenting intervention for Hispanic sexual minority youth in preventing/reducing drug use and depressive symptoms. It will also examine whether the intervention improves parent social support for the adolescent, parent acceptance, family functioning, and whether it reduces general stress and stress associated with being a Hispanic sexual minority. The knowledge expected to be gained from this study has the potential to transform the type of prevention programs that are disseminated to communities to improve the health of Hispanic sexual minority youth.

PI_NAMEs: PRADO, GUILLERMO  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;adolescent drug use;Advocate;Affect;arm;Communication;Communities;Community Practice;COVID-19;cultural values;Data;depressive symptoms;design;Development;Disclosure;Discrimination;drug abuse prevention;Drug Targeting;Drug usage;efficacy evaluation;evidence base;experience;Face;Family;family support;Frequencies;Gender;gender difference;Goals;Group Processes;Health;Health Promotion;Heterogeneity;Heterosexuals;high risk;Hispanic;Hispanic Populations;Homophobia;improved;Individual;Intervention;intervention effect;Knowledge;Learning;Libido;Mediating;Mental Depression;minority stressor;Not Hispanic or Latino;Outcome;parent-adolescent communication;parental involvement;parenting intervention;Parents;peer;Peer Pressure;Pharmaceutical Preparations;Pilot Projects;pilot test;prevent;Prevention program;preventive intervention;Process;psychologic;Publishing;racism;Randomized;Randomized, Controlled Trials;Reaction;Reporting;resilience;Risk;Risk Behaviors;Risk Reduction;Role;sexual minority;sexual minority stress;sexual minority youth;skills;Social support;standard of care;Stress;stress management;syndemic;trial design;Work;Youth

PROJECT_TITLE: Promoting Health and Reducing Risk among Hispanic Sexual Minority Youth and their Families

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: NARRATIVE The goal of the Building Access to Food through Systems and Solidarity (BASIS) Study is to improve diet by  providing culturally appropriate food access and attending to drivers that limit the ability to achieve nutrition  security in Sunset Park – a community of Mexican and Chinese American families in Brooklyn, NY that has been  hard-hit during the COVID-19 pandemic, has lagged in economic recovery, and where residents are  disconnected from government supports. We aim to implement and evaluate a whole-of-community intervention that will prioritize sustainability in the long-term, in partnership with four farming/gardening organizations, one  elementary school and three community-based organizations with programmatic offerings that will include  linkage to federal, state and local aid and workforce development; a subsidized fresh produce box program,  gardening and nutrition education; and a social marketing campaign to promote healthy eating. BASIS presents  a powerful model to improve diet in immigrant communities by addressing determinants of food access in a  community-centered, culturally competent way, and by fortifying community empowerment.

PI_NAMEs: YI, STELLA S (contact)

PROJECT_TERMS: Academia;Acceleration;Address;anti-Asian;Area;Asian Americans;Awareness;behavior change;built environment;Businesses;cardiometabolism;Cessation of life;Chinese American;Collaborations;Communities;community empowerment;community engaged research;community intervention;community organizations;community-centered;COVID-19 pandemic;cultural competence;Data Sources;Diabetes Mellitus;diabetes risk;Diet;Documentation;Economics;elementary school;Environment;Essential worker;ethnic minority population;Ethnic Origin;Evaluation;experience;Face;Family;Farm;Financial Support;Food;Food Access;Food Industry;Food Policy;Food Services;Fortification;Fright;Goals;Government;Health Disparities Research;health disparity;Healthy Eating;high risk;Immigrant;Immigrant community;implementation science;improved;Individual;Industry;Inequity;infrastructure development;Investments;Language;Latinx;Low income;Methods;Mexican Americans;Modeling;Needs Assessment;Neighborhoods;New York City;non-alcoholic fatty liver disease;nutrition;nutrition education;Outcome;Outcome Assessment;pandemic disease;Population;Program Development;programs;Public Health;racial minority population;Recovery;Research;Resources;Science;Security;Shame;social;social cohesion;Social Marketing;solidarity;Stimulus;Strategic Planning;Surveys;System;Trust;Unhealthy Diet;United States National Institutes of Health;vulnerable community;Workforce Development


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Guaranteed Basic Income (GBI) could address deep systemic social and structural inequities that lead to health disparities in Black youth, with potential to improve the financial, mental and physical well-being of Black emerging adults during their critical period of transition to independence. This study includes implementation and evaluation of an innovative, multilevel intervention to address grave inequities in health by providing GBI and access to financial coaching, peer-support, and real-time monitoring of needs and referral to services. The project will provide critical data needed to understand the potential of GBI for Black youth and how to maximize its impact on health with targeted programming at a time when multiple municipalities are considering GBI legislation.

PI_NAMEs: LIBBY, MARGARET ;LIGHTFOOT, MARGUERITA A.;LIPPMAN, SHERI ANN (contact)

PROJECT_TERMS: Accidental Injury;Acute;Address;Adult;Affect;Age;aged;Anxiety;arm;Behavior;Behavioral Research;Black race;black women;California;Cause of Death;Cellular Phone;Chlamydia;Cities;Communities;community partners;Coupled;critical period;Cross-Over Trials;Crossover Design;Data;depressive symptoms;design;Development;Discrimination;economic disparity;Economics;Education;education pathway;Effectiveness;emerging adult;emerging adulthood;Emotional;Employment;Enrollment;Ensure;Evaluation;experience;Exposure to;Family;Family Planning;follow-up;Future;Gonorrhea;Health;Health behavior;health disparity;health equity;health inequalities;Health Services Needs;help-seeking behavior;HIV Infections;HIV/STD;Human Papilloma Virus Vaccination;improved;Income;Individual;Inequity;innovation;insight;Intervention;Investments;Lead;Life;Low income;Low Income Population;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Monitor;Mood Disorders;multidisciplinary;Municipalities;Outcome;outcome disparities;Participant;payment;peer learning;peer support;Personal Satisfaction;Phase;physical conditioning;Policies;Policy Maker;Politics;Population;Populations at Risk;Poverty;programs;Psyche structure;Randomized;real time monitoring;Reduce health disparities;referral services;Reproductive Health Services;Research;response;Risk Taking;Savings;Science;Security;service gap;Service provision;service utilization;Services;sexual and reproductive health;social;social determinants;social health determinants;Statutes and Laws;Suicide;System;Testing;Time;Training;Training and Education;transition to adulthood;United States;Volatilization;White Women;Work;working group;young adult;Youth

PROJECT_TITLE: Increasing financial and health equity among low income black youth and young adults


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Firearms Research;Homicide and Legal Interventions;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: The Mississippi Violent Injury Prevention (VIP) Program is for the University of Mississippi Medical Center (UMMC) to partner with the communities to prevent firearm related violence, injury and mortality through a comprehensive approach of screening, brief intervention, and referral for treatment (SBIRT).

PI_NAMEs: KUTCHER, MATTHEW E;VEARRIER, LAURA ;ZHANG, LEI  (contact)

PROJECT_TERMS: Address;Adoption;Advocacy;Affect;Agreement;Area;arm;Assessment tool;Capital;Caring;Censuses;Clinical Trials;Communities;community intervention;Consult;data streams;Death Rate;Development Plans;Discipline;Discipline of Nursing;economic evaluation;economic impact;Elements;Emergency Medicine;Enrollment;Feedback;Firearms;follow-up;Funding;Government;Gun injury;gun violence;health economics;Homicide;Hospitals;Incidence;Individual;Injury;interest;Intervention;Joints;Laws;Link;Measures;Medical center;member;metropolitan;Mission;Mississippi;Monitor;mortality;Murder;Needs Assessment;operation;Patients;Persons;Phase;Population;prevent;Prevention;Prevention approach;Prevention program;preventive intervention;program dissemination;programs;Psychology;Public Health;Quality of life;Recovery;Recovery of Function;remote sensing;Research;Research Design;Research Project Grants;Resource Development;Resources;Risk;screening, brief intervention, referral, and treatment;Site;social determinants;Standardization;Structure;successful intervention;Surveys;Survivors;telehealth;Testing;tool;trauma centers;Universities;Violence;violence prevention;Violent injury;Work;working group

PROJECT_TITLE: A Proposal to Establish the Mississippi Violence Injury Prevention (VIP) Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CCHI-B(50)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cost Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative The public health impact of rejecting federal funding for community-based HIV services in Tennessee is likely to be profound, with the potential to widen disparities in HIV testing and prevention services for racial, sexual/gender, and rural residential minorities. Thus, our overarching goal is to provide a near-real-time evaluation of whether and how policy changes to funding HIV testing and prevention in Tennessee will affect HIV outcomes, particularly among populations highly vulnerable to HIV. Although focused on Tennessee, results are relevant to broader policy discussions around the direction of federal funding to community-based organizations for public health programs already emerging across the US South.

PI_NAMEs: MCKAY, TARA ;PETTIT, APRIL  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;AIDS prevention;Area;Award;Behavioral;black men who have sex with men;Black Populations;Black race;burden of illness;care outcomes;Caring;Categories;Cells;Centers for Disease Control and Prevention (U.S.);Child;Client;Clinical;clinical care;Communities;community organizations;community transmission;Continuity of Patient Care;cost;cost effectiveness;cost per quality-adjusted life year;County;Data;Data Sources;Diagnosis;Disease;Disparity;Disparity population;economic evaluation;Ensure;Epidemic;Ethnic Origin;Evaluation;Event;experience;first responder;Funding;Gender;Geography;Goals;Grant;Health;Health Disparities Research;Health Policy;Health system;high risk;Hispanic Populations;HIV;HIV diagnosis;HIV Infections;Human;Human immunodeficiency virus test;improved;Incidence;Individual;Institution;Interview;Knowledge;Link;Measures;men who have sex with men;Methods;metropolitan;Minority;Modeling;mortality;National Institute on Minority Health and Health Disparities;Outcome;Persons;Phase;Policies;Policy Analysis;Population;Positioning Attribute;pre-exposure prophylaxis;Pregnant Women;Prevention program;prevention service;programs;Public Health;Qualitative Research;Quality-Adjusted Life Years;Quasi-experiment;Race;Research Priority;Rural;rural area;rural dwellers;Sampling;service organization;Services;Sex Orientation;social;Social Impacts;Surveillance Program;Tennessee;testing services;Time;trafficking;transmission process;Trust;United States;Viral;Viral Load result;WFDC1 gene;Work

PROJECT_TITLE: A Multimethod Assessment of the Clinical, Economic & Social Impact of the Rejection of Federal HIV Prevention Funds in Tennessee


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homicide and Legal Interventions;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: This cooperative agreement project entails formative research to finalize intervention elements and data collection protocols, followed by the implementation and evaluation of a unique community-level intervention to prevent firearm violence among youth in a Washington, DC community.

PI_NAMEs: EDBERG, MARK  (contact)

PROJECT_TERMS: Academic support;Address;Affect;African American;Age;Area;Attitude;authority;Baseline Surveys;Behavior;Behavioral;Cause of Death;Cities;cohort;Collaborations;Collection;Communication;Communities;community center;community collaboration;Community Health;community intervention;community organizations;community partners;Data;Data Analyses;Data Collection;data sharing;design;Development;District of Columbia;Elements;Ethnic Population;Evaluation;expectation;Female;Firearms;follow-up;Gender;Genus Mentha;gun violence;health disparity;Health Service Area;Homicide;Housing;Information Dissemination;instrument;Intervention;intervention effect;journal article;Lawyers;Life;Life Cycle Stages;Link;male;Manuals;marginalization;Mediator;meetings;Mentors;metropolitan;minority children;Outcome;Parents;Pathway interactions;Pattern;Persons;Phase;pilot test;Police;positive youth development;Poverty;prevent;Prevention;preventive intervention;Process;programs;Protocols documentation;Public Health;Public Health Schools;Quasi-experiment;racial population;racism;recruit;Research;Sampling;Shotguns;social media;social norm;socioeconomics;study population;Surveys;theories;Time;Training;U-Series Cooperative Agreements;Universities;Violence;violence prevention;violent crime;Washington;web site;Youth

PROJECT_TITLE: Changing the Narrative on Firearms Violence: A Community Collaborative Intervention


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

PHR: PROJECT NARRATIVE Transgender women (trans women; women who were assigned male at birth) experience a disproportionate burden of sexually transmitted infections (STIs) such as human immunodeficiency virus (HIV), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Syphilis, however, there is a noted paucity of literature examining non-HIV STIs. Expanded efforts are needed to explore new STI screening options to increase STI testing rates among trans women and examine the relationship between individual, interpersonal and community factors and STI risk among trans women. Thus, this proposed K99/R00 aims to validate self-collected specimens for STI testing among trans women and examine the differences in STI prevalence and socio-spatial STI risk factors between trans women with and without neovaginas using self-collected samples.

PI_NAMEs: COUDRAY, MAKELLA S. (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Appointment;Area;assigned male at birth;barrier to care;Biological;Birth;career;career development;Caring;Characteristics;Chlamydia trachomatis;Collaborations;community based research;community-level factor;cultural competence;Data;Development;Discrimination;Early Diagnosis;Early treatment;efficacy evaluation;Epidemiologic Methods;Epidemiology;experience;Face;Florida;Friends;gender minority health disparity;genital surgery;Genitalia;Geographic Information Systems;Goals;Grant;health care availability;health care settings;Health Disparities Research;health disparity;health inequalities;Health Services Accessibility;Healthcare;HIV;Individual;Infection;Infection prevention;infection risk;innovation;Intervention;intervention mapping;Interview;Knowledge;Laboratories;Literature;male;marginalized population;Mentors;Mentorship;Methodology;Methods;minority health;minority health disparity;National Institute on Minority Health and Health Disparities;Neighborhoods;Neisseria gonorrhoeae;neovagina;novel strategies;Pathway Analysis;Patient Self-Report;Patients;Pharyngeal structure;Phase;Pilot Projects;Population;Positioning Attribute;Postdoctoral Fellow;Predisposition;Prevalence;Prevention;Prevention Research;preventive intervention;Procedures;Provider;Qualitative Research;recruit;Rectum;Reporting;Research;Research Methodology;Research Personnel;Risk;Risk Factors;Sampling;Scientist;screening;Secure;Sexual and Gender Minorities;sexual risk behavior;Sexually Transmitted Diseases;Site;skills;social;social capital;social epidemiology;Social Network;social stigma;Social support;spatial epidemiology;Specimen;STI prevention;Surveys;Syphilis;Target Populations;tenure track;Testing;Tissues;Training;transgender;transgender women;Universities;vaginoplasty;Woman

PROJECT_TITLE: Sexually Transmited Infection Testing Risk and Prevention among Trans Women (STRiP-T)


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Skin Cancer;Telehealth

ORG_CITY: Newark

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Research on preventing skin cancer among the Hispanic population is needed since melanoma rates are increasing among Hispanics, and mortality rates are higher than among non-Hispanic whites. The Hispanic population tends to have misperceptions regarding skin cancer: they are less aware of the symptoms and harms of skin cancers and are less likely to engage in sun protection behaviors. The proposed project will develop and pilot test a mobile intervention to increase both sun protection and skin self-examination behaviors among Hispanic individuals.

PI_NAMEs: NIU, ZHAOMENG  (contact)

PROJECT_TERMS: acceptability and feasibility;Acculturation;Address;Adolescent;anti-cancer research;arm;Awareness;Behavior;Behavior Therapy;Benefits and Risks;Cancer Intervention;career;Cellular Phone;Child;Communities;cost;cost effective;Data;Death Rate;Development;Diagnosis;digital intervention;digital technology;Early Diagnosis;efficacy evaluation;Ethnic Population;evidence base;experience;Focus Groups;follow-up;Foundations;Funding;Future;Genomics;Grant;Health;Health behavior;health disparity;Health Personnel;Hispanic;hispanic community;Hispanic Populations;Hispanic Women;improved;improved outcome;Incidence;Individual;industry involvement;information gathering;innovation;Intervention;intervention effect;intervention refinement;Interview;Malignant Neoplasms;Melanoma;member;Mentors;mhealth interventions;Multimedia;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;nutrition;Occupational;Occupational Exposure;Occupations;Outcome;Participant;patient engagement;Perception;Persons;Phase;Physical activity;Pilot Projects;pilot test;Population;Population Heterogeneity;Populations at Risk;post intervention;Preparation;prevent;Preventive;Process;programs;Protocols documentation;public health intervention;racial population;Randomized, Controlled Trials;Reporting;Research;Research Project Grants;retention rate;Risk;Risk Factors;Risk Reduction;Risk Reduction Behavior;Sampling;satisfaction;scale up;Self-Examination;Services;Skin;Skin Cancer;skin cancer prevention;social culture;Suggestion;Sum;sun protection;sun safety;Sunscreening Agents;Surveys;Survival Rate;Symptoms;Testing;theories;therapy development;Time;Training;Treatment Efficacy;tumor;Ultraviolet Rays;Underserved Population;United States;UV Radiation Exposure;web-based intervention

PROJECT_TITLE: Developing and testing a mobile health intervention to promote sun protection behaviors and skin examination among Hispanics