NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Pediatric;Precision Medicine

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The study will predict height velocity, growth potential, and early treatment response to growth hormone in children using diffusion tensor MRI of the physis and metaphysis. This tool will allow clinicians to personalize therapy for short stature and other skeletal abnormalities and researchers to better understand growth disorders.

PI_NAMEs: JAMBAWALIKAR, SACHIN  (contact)

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: 3-Dimensional;Address;Adolescent;Age;Anisotropy;Biological Markers;bone;bone age;Bone Growth;boys;Cartilage;Child;Childhood;Clinical;clinical decision-making;cohort;comparison control;cost;Data;Deformity;Diagnostic Procedure;diagnostic tool;Diffusion;Diffusion Magnetic Resonance Imaging;Distal;Early Diagnosis;Early identification;Early treatment;Elements;Epiphysial cartilage;Failure;Femur;follow-up;Functional disorder;girls;Goals;Growth;Growth Disorders;Growth Factor;Hand;Health Care Costs;Height;hormone therapy;Image;Immature Bone;improved;in vivo;Injections;Insulin;Knee;Knowledge;Leg;Length;ligament injury;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Metaphysis;Methods;Microscopic;Modeling;Morphology;Motion;novel;Operative Surgical Procedures;Organ;Orthopedic Procedures;Orthopedics;Patient Selection;personalized medicine;Pharmaceutical Preparations;Precision therapeutics;predictive tools;Predictive Value;prevent;Puberty;Research Personnel;Residual state;response;scoliosis;skeletal;skeletal abnormality;skeletal disorder;Somatotropin;Structure;success;Techniques;Testing;Time;Tissues;tool;tractography;treatment response;Water;water diffusion;Water Movements

PROJECT_TITLE: Understanding Skeletal Growth Using Diffusion Tensor Imaging of the Physis and Metaphysis

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: WINSTON-SALEM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE - CENTER OVERVIEW The Proposed North Carolina Diabetes Research Center (NCDRC) seeks to foster diabetes-related research among investigators – whether established, early-career, or new to the field – at and among 4 premier research institutions in the state (Duke, University of NC at Chapel Hill, NC A&T, and Wake Forest). The Pilot and Feasibility Core will provide funding for the most promising ideas among NCDRC scientists; the Core services will provide access to unique resources and expertise among all 4 campuses, and their cadre of Research Navigators will enable the studies’ efficient completion; and the Enrichment Program will plan and sponsor an annual symposium, to which NIH-supported trainees and investigators whose work could inform the future of diabetes research will be especially invited.

PI_NAMEs: MCCLAIN, DONALD A. (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Address;Agriculture;Automobile Driving;base;career;Clinical and Translational Science Awards;clinical care;Clinical Research;Clinical Sciences;Cluster Analysis;Collaborations;Communities;Dedications;Diabetes Mellitus;diabetes risk;diabetic patient;Doctor of Philosophy;Education;epigenomics;Fostering;Funding;Future;Genomics;Goals;Grant;hospital care;Infrastructure;innovation;Institution;inter-institutional;Interdisciplinary Study;interest;International;Leadership;Link;medical schools;member;metabolomics;Methods;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;North Carolina;novel;outreach;Pathway Analysis;Patients;Persons;Phenotype;Productivity;programs;Proteomics;Recording of previous events;recruit;Research;Research Design;Research Infrastructure;Research Personnel;Research Support;Resource Sharing;Resources;Scientist;Services;Site;Solid;symposium;Techniques;Training;Training and Education;Training Programs;Translating;translational approach;translational pipeline;translational study;Translations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: North Carolina Diabetes Research Center


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Genetics;Human Genome

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PI_NAMEs: COSGROVE, BENJAMIN DAVID (contact)

PROJECT_TERMS: antagonist;Architecture;ATAC-seq;Atlases;Attention;Automobile Driving;Awareness;biobank;Bioinformatics;Biological Assay;Biological Markers;biological sex;Biological Specimen Banks;Biopsy;Biopsy Specimen;Blood;Blood specimen;Blood Vessels;Cell Communication;Cell Culture Techniques;Cell Nucleus;cell type;Cells;Cellular Assay;Chronic Fatigue Syndrome;cohort;Collection;Coupled;Custom;Data;Data Set;Databases;Diagnosis;Disabling;Disease;Endothelial Cells;endothelial dysfunction;Endothelium;Engineering;Epigenetic Process;epigenome;epigenomics;Etiology;Exertion;Exposure to;Fatigue;Functional disorder;Gene Expression;Genes;Genetic Transcription;Hand Strength;Health;Histopathology;Homeostasis;Human;human model;Immune;Immune System Diseases;Immunophenotyping;Individual;innovation;insight;intercellular communication;Ligands;Link;Maps;Mediator;Metabolic;Metabolic dysfunction;Methods;MicroRNAs;Modeling;Molecular;monocyte;multiple omics;Muscle;Muscle Cells;Muscle Fatigue;Muscle Fibers;muscle metabolism;Myeloid Cells;Needles;neutralizing antibody;novel;Pathway interactions;Patients;Peripheral;Physiological;Physiology;Plasma;Prevalence;programs;receptor;recruit;Regulation;repaired;Research;Resolution;RNA;Role;Sampling;Severities;Signal Pathway;Signal Transduction;single cell technology;single nucleus RNA-sequencing;single-cell RNA sequencing;Skeletal Muscle;Small Nuclear RNA;Surveys;Symptoms;System;systemic inflammatory response;Testing;therapeutic target;transcriptome;transcriptome sequencing;transcriptomics;Untranslated RNA;Urine;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelium

PROJECT_TITLE: Dissecting myogenic-endothelial-immune interactomes in human ME/CFS skeletal muscles

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-N]


NIH_SPENDING_CATS: Diabetes;Nutrition

PROJECT_TERMS: Advisory Committees;Advocate;Agreement;Alzheimer's Disease;American;Attention;Award;base;Behavioral Sciences;Biology;Biomedical Engineering;Clinical and Translational Science Awards;Clinical Sciences;Collaborations;Communities;community engagement;Community Outreach;Consultations;Cystic Fibrosis;Data;Dentistry;Diabetes Mellitus;Discipline;Discipline of Nursing;Disease;Educational workshop;Environmental Health;Evaluation;experience;gastrointestinal;Genetic;Goals;Grant;Health Sciences;Historically Black Colleges and Universities;Home;improved;Infrastructure;innovation;Institute of Medicine (U.S.);Institution;Investigation;Knowledge;Leadership;meetings;member;National Institute of Diabetes and Digestive and Kidney Diseases;neural;North Carolina;novel;nutrition;Obesity;outreach;Pharmacology;Prevention;programs;Public Health;Publications;Regenerative Medicine;Reporting;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;satisfaction;Schools;Scientific Advances and Accomplishments;Site;Speed;Structure;translational medicine;Translational Research;Translations;United States National Institutes of Health;Universities;Utilization Review;web site


PI_NAMEs: MONGRAW-CHAFFIN, MORGANA LEE (contact)

PROJECT_TERMS: Bioinformatics;Biological;biological systems;Cells;Clinical;Clinical Management;Complement;Complex;Computer Analysis;cost efficient;Data;Data Analyses;data integration;Development;Diabetes Mellitus;diabetes risk;Disease;Disease Progression;disorder risk;DNA;DNA Methylation;DNA sequencing;Epigenetic Process;epigenetic regulation;epigenomics;exosome;experience;Faculty;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Genetic Determinism;Genetic Predisposition to Disease;Genetic Transcription;Genome;Genomics;Goals;Health Sciences;Individual;individual patient;Institution;instrumentation;Knowledge;Label;Lipids;Lipoproteins;Mass Spectrum Analysis;member;metabolomics;Metagenomics;Mitochondria;Molecular;Molecular Profiling;multiple omics;next generation sequencing;North Carolina;novel strategies;particle;Pathway Analysis;Plasma;Play;Post-Translational Protein Processing;precision medicine;Preparation;Process;programs;Proteins;Proteomics;Research;Research Design;Research Personnel;Resources;Risk;RNA;sample collection;Sampling;Serum;Services;small molecule;Small RNA;Stable Isotope Labeling;statistics;stool sample;System;Technology;Time;Tissues;tool;transcriptome sequencing;Universities;Variant;whole genome;Work


PI_NAMEs: NEWGARD, CHRISTOPHER B (contact)

PROJECT_TERMS: Address;Bioinformatics;Biological;Biological Assay;biomarker discovery;Blood;Body Fluids;Cardiometabolic Disease;cardiovascular risk factor;chemical property;Chemicals;Collaborations;Computational Biology;Computer Analysis;Data Analyses;Dedications;Development;Diabetes Mellitus;diabetes pathogenesis;Disease;Educational workshop;Elements;Ensure;experience;Faculty;Feces;genomic platform;Genomics;Human Resources;Incidence;Infrastructure;Institution;instrument;Insulin Resistance;insulin secretion;Investments;Knowledge;Laboratories;Letters;Light;Measurement;Measures;medical schools;member;Metabolic;metabolome;metabolomics;Methods;Mission;Molecular;muscle physiology;nanomolar;North Carolina;Obesity;Organism;outreach;Phenotype;Physiological;Physiology;predictive marker;Process;programs;Proteomics;Recording of previous events;Reproducibility;Research;Research Design;Research Personnel;Research Support;sample collection;Science;Seminal;Services;Severities;Skeletal Muscle;Students;Surveys;Technology;Tissue Extracts;Tissues;transcriptomics;Urine;Work


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CLEMSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PUBLIC HEALTH RELEVANCE: Acute infarction due to ischemia/reperfusion (I/R) is a major cause of heart failure, a disease that affect over 6 million Americans and is associated with over 10% death in the US. The goal for the proposed research is to develop exosomes from the nanowired human isogenic cardiac organoids to treat infarcted patients.

PI_NAMEs: MEI, YING  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;Acute;Affect;American;angiogenesis;Attention;Attenuated;Biogenesis;Biomimetics;Blood Vessels;Cardiac;Cardiac Myocytes;cardiac repair;cardioprotection;Cardiovascular system;cell replacement therapy;Cell secretion;Cell Therapy;cell type;Cells;Cessation of life;Coculture Techniques;Data;density;design;Diameter;Disease;Electric Conductivity;Endothelial Cells;Environment;exosome;Fibroblasts;Fibrosis;Goals;Harvest;Heart failure;Heart Injuries;Human;Human Engineering;human pluripotent stem cell;Hypertrophy;immunogenicity;immunoregulation;implantation;improved;in vivo;Infarction;innovation;Ischemia;large scale production;Lipids;MicroRNAs;mimetics;Myocardial Infarction;Myocardium;nanofabrication;nanomaterials;nanoparticle;nanowire;next generation;Organ;Organoids;Pathologic;Patients;Persons;preservation;Production;Property;Proteins;public health relevance;Rattus;Recovery of Function;Regenerative Medicine;Reperfusion Injury;Reperfusion Therapy;Reproducibility;Research;Risk;RNA;Signal Transduction;Silicon;Source;spheroids;Stromal Cells;Structure;synergism;Therapeutic;three dimensional cell culture;Time;Tissue Engineering;Tissues;Treatment Efficacy;tumorigenic;Vascularization

PROJECT_TITLE: Nanowired humam cardiac organoid derived exosomes for heart repair

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Chicago

ORG_NAME: ACOUSTIC RANGE ESTIMATES, LLC

ORG_STATE: IL

PHR: Ion therapy concentrates dose in a small treatment “spot” and can minimize collateral damage to nearby healthy tissue – if dose is targeted accurately. Therefore, verifying that dose is delivered to the tumor, rather than nearby healthy tissue is critical, but not yet well addressed by today’s ion therapy systems. During Phase II, Acoustic Range Estimates will finalize design and validate a wireless thermoacoustic range verification system that computes range estimates and acquires ultrasound images of the patient during treatment.

PI_NAMEs: PATCH, SARAH KATHRYN (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: 3D Print;Acoustics;Address;Agreement;American;analog;Anatomy;base;Body Weight decreased;bundled payment;Caring;Certification;Charge;Chronic;Clinic;Clinical;clinical efficacy;Closure by clamp;Collaborations;Computer software;Computer Systems;cone-beam computed tomography;cost effectiveness;Cost efficiency;Custom;Data;data acquisition;Defecation;Deposition;design;detector;Devices;Digestion;Distal;Dose;dosimetry;Edema;Electronics;Environment;Equipment Failure;experimental study;Eye;Frequencies;Funding;Gases;Gelatin;Goals;Hybrids;Hydrogels;Image;Imaging Phantoms;improved;innovation;Intestines;Ions;Kidney;Legal patent;Liver;Magnetic Resonance Imaging;Manufacturer;Medicare;millimeter;Modeling;Monitor;Monte Carlo Method;Morphology;Motion;Multimodal Imaging;Neck;Noise;Organ;Pancreas;particle;particle therapy;Patient imaging;Patients;pediatric patients;Performance;Phase;Photons;Positioning Attribute;Protocols documentation;proton beam;proton therapy;prototype;radiation detector;Radiation Oncology;Radiation therapy;Research;research study;Respiration;Rest;Roentgen Rays;Sampling;Secure;Selection for Treatments;Signal Transduction;Site;Societies;soft tissue;software systems;Solid Neoplasm;Speed;Spottings;Stress;Structure;success;Synchrocyclotron;System;Techniques;Testing;Therapeutic;Time;Tissues;Treatment Cost;treatment planning;tumor;Ultrasonography;ultrasound;Uncertainty;Universities;Validation;Vertebral column;Visualization;Washington;wireless;X-Ray Medical Imaging

PROJECT_TITLE: Thermoacoustic Range Verification During Delivery of a Clinical Plan by a Synchrocyclotron: transition from research prototype to turnkey clinical device


NIH_SPENDING_CATS: Diabetes

PI_NAMEs: ALLRED, NICHOLETTE D. (contact)

PROJECT_TERMS: Academy;Award;career;Clinical and Translational Science Awards;clinical research site;collaborative environment;Creativeness;Data;Diabetes Mellitus;Education;Equity;Feasibility Studies;Funding;Funding Mechanisms;Goals;Grant;improved;Individual;Infrastructure;innovation;Institution;Leadership;member;Mentors;Mission;North Carolina;novel;novel strategies;Outcome;Pilot Projects;Policies;prevent;Process;programs;Reproducibility;Research;Research Personnel;Research Support;Resources;Safety;Site;translational potential;Translations;United States National Institutes of Health;Vision;Work


NIH_SPENDING_CATS: Biotechnology;Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Genetics;Physical Activity

PI_NAMEs: HANSON, MAUREEN REBECCA (contact)

PROJECT_TERMS: Affect;Aptamer Technology;Biological Assay;Biological Markers;Biological Process;biomarker identification;biomarker signature;Biopsy;Blood;Blood - brain barrier anatomy;Blood Platelets;Blood specimen;Blood Vessels;Brain;Cardiopulmonary;Cell Death;Cell Physiology;cell type;Cells;Chronic Fatigue Syndrome;Circulation;Classification;Clinical;clinically relevant;Cluster Analysis;Cognitive;cohort;Collaborations;Collection;comparison control;Data;Diagnostic;Diagnostic tests;disabling symptom;Disease;Disease Marker;Endothelial Cells;endothelial dysfunction;Endothelium;Exercise;Exercise Physiology;Exercise Test;Exertion;experience;extracellular vesicles;Fatigue;Fluorescent Probes;Functional disorder;Gene Expression;Generations;Growth;Hormones;Hour;Immune;immune activation;improved;Incubated;Individual;Inflammatory;insight;Learning;lipidomics;Lipids;Malaise;Measures;Mediating;Membrane;Metabolic;metabolomics;MicroRNAs;Molecular Profiling;multiple omics;Muscle;Nature;Neurons;Nitric Oxide;novel;Organ;orthostatic intolerance;Pain;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Physical Efforts;Physiological;Plasma;Play;predictive modeling;Preparation;Proteins;Proteomics;Psyche structure;Quality of life;Reactive Oxygen Species;Recovery;Research;response;RNA;Role;Sampling;sedentary;Series;Signal Transduction;Signaling Molecule;Signaling Protein;Sleep;Source;Symptoms;System;Technology;Time;time use;tissue injury;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;transcriptomics;Travel;treatment effect;Vascular Endothelial Cell;vesicular release;Work

PROJECT_TITLE: Circulating signals of ME/CFS


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Nutrition;Obesity;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Teenage Pregnancy;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Excessive weight gain during pregnancy among pregnant young women is associated with serious multi- generational morbidity for both the mother and infant. This project will advance the scientific knowledge about the effect of grocery delivery on weight gain and diet during pregnancy among low-income pregnant young women who have limited access to healthy foods.

PI_NAMEs: CHANG, TAMMY  (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Age;Age Years;arm;Behavior;beneficiary;Beverages;Birth;Child;child services;Chronic Disease;Consumption;Control Groups;cost;Dangerousness;Data;design;Diet;dietary;Eating;education resources;effective intervention;Enrollment;excessive weight gain;experimental group;Face;fetal;First Births;First Pregnancy Trimester;Food;fruits and vegetables;Future;Genetic Programming;Gestational Diabetes;gestational weight gain;Goals;good diet;Government Programs;Health;health disparity;Health Food;Healthy Eating;healthy weight;Home;Hypertension;improved;Infant;innovation;Intervention;intervention cost;Knowledge;Low income;Morbidity - disease rate;Mothers;National Institute of Child Health and Human Development;Obesity;peer;perinatal complications;perinatal outcomes;Policies;Population;Pregnancy;pregnant;Pregnant Women;prevent;Prevention;program costs;programs;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Risk;Scientific Advances and Accomplishments;Services;Societies;Special Supplemental Nutrition Program for Women, Infants, and Children;sugar;sweetened beverage;Testing;Time;Transportation;Unhealthy Diet;Vulnerable Populations;Weight;Weight Gain;Woman;young mother;young woman;Youth

PROJECT_TITLE: Grocery Delivery to Promote Healthy Weight Gain Among Low-Income Pregnant Young Women

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Influenza;Orphan Drug;Pneumonia and Influenza;Prevention;Rare Diseases;Sleep Research;Vaccine Related

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE: Narcolepsy results from the immune-mediated loss of about 70,000 neurons that produce the wake-promoting, REM sleep-reducing brain chemical "hypocretin" (also called "orexin"), specifically, the immune system mistakenly targets parts of hypocretin neurons that are similar to portions of a flu virus. This misdirected immune response could explain why a particular pandemic flu vaccine used in Europe in 2009-2010 increased the risk of developing narcolepsy in Europe but not the United States. The goal of this project is to isolate flu-reactive immune cells of individuals with and without narcolepsy, characterize any differences in these cells, and study how those differences contribute to the immune-mediated death of hypocretin neurons and producing narcolepsy, this high impact research will lead to blood diagnostic tests, preventive measures, and new therapies.

PI_NAMEs: MIGNOT, EMMANUEL J (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Adjuvant;Affect;alpha-beta T-Cell Receptor;amidation;Animal Model;Antigen Presentation;antigen processing;Antigen-Presenting Cells;Antigens;Autoantigens;Autoimmune Diseases;Autoimmune Process;Autoimmune Responses;autoreactivity;Binding;Biological Assay;Blood;Blood Tests;Brain;C-terminal;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Death;Cell model;Cells;Cessation of life;Chemicals;Child;China;Code;cross reactivity;Data;Dendritic cell activation;design;Diagnostic;Diagnostic tests;Disease;Environmental Risk Factor;Epitope spreading;Epitopes;Europe;flu;Flu virus;Frequencies;Genes;genetic association;Genetic Polymorphism;Genetic Risk;Genetic study;Genome;Genomics;Genotype;Goals;high risk population;HLA-A gene;HLA-DP Antigens;HLA-DQA1;HLA-DR Antigens;Human;hypocretin;IFNAR1 gene;Immune;Immune response;Immune system;Immunization Programs;Immunology;improved;Incidence;Individual;Influenza;Influenza A Virus, H1N1 Subtype;Influenza Hemagglutinin;influenza virus vaccine;influenzavirus;Jurkat Cells;Knowledge;Laboratories;Ligands;Maps;Mediating;Modeling;Molecular Mimicry;Narcolepsy;Neurons;novel therapeutics;pandemic disease;pandemic influenza;Pathogenicity;Patients;Peptides;Persons;Phenotype;Post-Translational Protein Processing;Predisposition;Prevention strategy;Preventive measure;Process;Publishing;Reagent;receptor;Receptor Cell;REM Sleep;Research;Research Personnel;response;Risk;Role;Safety;Sequence Homology;single cell sequencing;single-cell RNA sequencing;Sorting;Symptoms;T cell receptor repertoire sequencing;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Technology;Transfection;United States;Vaccination;Vaccines;Virus

PROJECT_TITLE: Pandemrix and T Cell Immunology in Narcolepsy

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: AG

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Here we propose to apply two innovative sequencing technologies to postmortem control and Alzheimer’s disease brains to obtain sing-cell-resolution transcriptomic and pathology measurements and then test disease- state driver genes in relevant and controllable human cell models using genetic screens.

PI_NAMEs: WANG, YANLING  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Acceleration;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Antibodies;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Autopsy;Bar Codes;beta amyloid pathology;Biotechnology;Brain;Brain region;brain tissue;Calibration;Candidate Disease Gene;candidate identification;Cataloging;cell cortex;Cell model;Cell Shape;cell type;Cells;cellular pathology;Cellular Stress;Chronic;clinical diagnosis;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Computer Analysis;Computing Methodologies;CRISPR screen;Data;deep learning;Dementia;design;Development;Disease;disease phenotype;Disease Progression;Dorsal;Environment;extracellular;Gene Expression;gene network;Genes;Genetic Screening;Genotype;Guide RNA;Hippocampus;Human;human model;In Vitro;indexing;Individual;induced pluripotent stem cell;Inflammation;innovation;Lateral;Measurement;Measures;Messenger RNA;Methods;Microglia;Molecular;mouse model;Mus;Neurofibrillary Tangles;Neurons;novel;Oligonucleotides;Participant;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phenotype;Prefrontal Cortex;prevent;protein TDP-43;Research;Resolution;response;Senile Plaques;single nucleus RNA-sequencing;single-cell RNA sequencing;stressor;Systems Biology;tau-1;Technology;Testing;therapeutic target;transcriptome;transcriptomics

PROJECT_TITLE: Uncovering cell-type-specific driver genes of Alzheimer's Disease by pathology-indexing scRNA-seq, spatial transcriptomics, and CRISPR screens


NIH_SPENDING_CATS: Chronic Fatigue Syndrome (ME/CFS);Clinical Research

PI_NAMEs: GRIMSON, ANDREW W (contact)

PROJECT_TERMS: Abnormal Monocyte;Basic Science;Biological Assay;Biological Markers;Blood;Blood Platelets;Cell Nucleus;cell type;Cells;Chronic Fatigue Syndrome;Circulation;Coagulation Process;cohort;Collaborations;Complement;Computing Methodologies;Cytoplasm;Data;Defect;Diagnosis;Disease;Disparate;Endothelium;Exertion;Exhibits;experimental study;extracellular vesicles;Foundations;Functional disorder;Future;Gene Expression Regulation;Genes;Genetic Complementation Test;Genomics;Goals;Immune;Immune system;Immune System Diseases;improved;innovation;insight;Ligands;Link;Macrophage;Malaise;Megakaryocytes;Memory;MicroRNAs;migration;Molecular;monocyte;multiple omics;Muscle;Musculoskeletal Pain;neuromuscular system;Neurons;Parents;particle;Pathway interactions;Patients;Physiology;platelet function;Platelet Function Tests;preference;Proteome;receptor;Research;Research Personnel;Resolution;Resources;Signal Pathway;Signal Transduction;Sleep;Symptoms;System;T-Lymphocyte Subsets;Testing;therapeutic development;Therapeutic Intervention;therapy development;Tissues;transcriptome;transcriptomics;Work;wound healing

PROJECT_TITLE: Immune dysfunction in ME/CFS


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The major diseases of pediatric and adult gastroenterology and hepatology suffer from a lack of safe and effective therapeutics. This need can best be addressed by developing a cadre of well-trained researchers devoted to discovering disease causes and developing new approaches to disease prevention or treatment. This T32 Training Grant prepares highly-motivated and talented post-doctoral MD, MD/PhD and PhD researchers with the multi-faceted tools in cutting edge research techniques, education, and practical career advice to address current and future unmet needs in gastroenterology and hepatology.

PI_NAMEs: KUGATHASAN, SUBRA  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TITLE: Research Training in Translational Gastroenterology and Hepatology


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Gene regulation and metabolism are among the most important processes driving health. While each of these processes has been mechanistically studied for individual molecules and pathways, little is known about how they influence each other at a systems level. In this project, we will continue our studies of the interplay between metabolism and gene expression using the nematode C. elegans as a model system.

PI_NAMEs: WALHOUT, A. J. MARIAN  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Address;Affect;Animal Model;Automobile Driving;Biochemical Pathway;Biological Models;Biological Process;Caenorhabditis elegans;Evolution;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic Screening;Health;Heart;human disease;Individual;insight;Metabolic;Metabolic Control;Metabolism;metabolomics;Molecular;Nematoda;Pathway interactions;Process;Resolution;Structure;System;Transcriptional Regulation

PROJECT_TITLE: Gene regulatory and metabolic network structure, function and evolution

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE All complex organisms have a smaller mitochondrial genome in addition to the larger nuclear genome. Many human diseases are caused by mutations in mitochondrial DNA, but the causes of mitochondrial mutations and their roles in physiology, health, and aging are poorly understood. The proposed work will characterize the properties of mitochondrial mutations, their physiological consequences, and their roles in aging using diverse eukaryotic model systems.

PI_NAMEs: HAVIRD, JUSTIN C (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Affect;Aging;Atlases;Biological Models;Cell Physiology;Characteristics;Complement;Complex;Disease;Disease Progression;Disparate;Environment;Equilibrium;Eukaryota;Frequencies;Genome;Health;Human;human disease;interest;Invertebrates;knock-down;life span;Link;Longevity;metabolic rate;Mitochondria;Mitochondrial DNA;mitochondrial genome;Mitochondrial Proteins;Modeling;Mouse Strains;Mutation;Natural Selections;Nematoda;Nuclear;Organelles;Organism;oxidative damage;Oxidative Phosphorylation;Oxidative Stress;Physiological;Physiological Processes;Physiology;Plants;Play;Population;Process;Production;Property;Proteins;Reactive Oxygen Species;Replication Error;Research;Role;Salamander;Shapes;Source;Superoxide Dismutase;System;theories;trait;Transcript;Work

PROJECT_TITLE: Causes and Consequences of Mitochondrial Mutations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Critical processes in cells are carried out through protein interactions that mediate function. This project will develop and apply quantitative in vivo cross-linking and novel mass spectrometry array technologies to gain greater insight on cellular interactome dynamics. These studies will enable improved understanding of human diseases such as cancer, molecular details of how cells alter function during drug treatment, including heat shock response that serves to limit many potential therapies and how cells alter functional pathways to confer chemoresistance.

PI_NAMEs: BRUCE, JAMES EDWARD (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TITLE: Dynamics of the cellular interactome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: IOWA CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE: Sepsis is a very dangerous whole-body response to infection or trauma that often leads to death due to overwhelming inflammatory and metabolic stress in critical organs such as the heart. In this project, using genetically-modified mouse models and blood samples from sepsis patients, we will test the hypothesis that a protein called PHB1 is released from the liver during sepsis and circulates throughout the body to protect the heart from tissue damage caused by this stress. This work will lay groundwork for new clinical tests and drugs that target sepsis-induced heart failure and other inflammatory diseases.

PI_NAMEs: ANDERSON, ETHAN JOHN (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Acute-Phase Proteins;Acute-Phase Reaction;Adult;Aerobic;Anti-Inflammatory Agents;Apoptosis;Biological;Biological Markers;Biomedical Engineering;Blood;Blood specimen;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cell Line;Cell membrane;Cell Physiology;Cessation of life;Characteristics;Clinical;Clinical Research;clinically relevant;cohort;Complex;COVID-19;Custom;cytokine;Dangerousness;Death Rate;Diagnosis;Disease;Drug Targeting;druggable target;Endotoxins;Enzyme-Linked Immunosorbent Assay;experimental study;Feedback;Functional disorder;Gene Modified;Genetic Transcription;Glucose;glucose metabolism;Heart;Heart failure;heart metabolism;heart preservation;Hepatocyte;Heterodimerization;Human;Incubated;Infection;Inflammatory;inflammatory marker;Injury;Inner mitochondrial membrane;insight;Knockout Mice;Label;Ligands;Liver;loss of function;Manuscripts;Measures;Mediating;Membrane Microdomains;Metabolic stress;Metabolism;Mitochondria;mitochondrial dysfunction;Molecular;Morbidity - disease rate;Morphology;mortality;mortality risk;mouse model;Multiple Organ Failure;Mus;Myocardial dysfunction;Myocardium;novel;Organ;overexpression;oxidation;Oxidative Phosphorylation;Oxidative Stress;Pathway interactions;Patients;Pentosephosphate Pathway;PIK3CG gene;predictive marker;preservation;Primary Cell Cultures;Production;Prognosis;prohibitin;Proliferating;Proteins;Proto-Oncogene Proteins c-akt;Publishing;Recombinants;Reporting;Research;response;Sampling;SARS-CoV-2 infection;scaffold;Scientist;Sepsis;septic;septic patients;Serum;severe COVID-19;Signal Transduction;stem;Stress;Structure;Techniques;Testing;Therapeutic;Time;Tissues;transcription factor;transcriptomics;Trauma;Universities;uptake;Utah;Work

PROJECT_TITLE: Determinants of cardioprotection by circulating prohibitin-1 during sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: MIDDLETOWN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WESLEYAN UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Copper (Cu) is necessary for growth, development and metabolism in humans. Abnormal Cu absorption, excretion or distribution results in health conditions, such as Menkes and Wilson diseases, and mitochondrial, neurological and cardiac pathologies. This project will characterize novel molecular mechanisms by which Cu and Cu-binding transcription factors regulate lineage-specific gene expression and muscle development, and will establish a basis to understand muscular phenotypes observed in multiple diseases related to Cu deficiencies at a transcriptional level.

PI_NAMEs: PADILLA-BENAVIDES, TERESITA DEL NINO JESUS (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: absorption;Affect;Ataxia;Binding;Binding Sites;Biochemical;Biochemical Reaction;Biology;Cardiac;Categories;Cell Differentiation process;Cell Lineage;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Cellular Stress;ChIP-seq;Chromatin;Chromatin Structure;Coenzymes;cofactor;Complex;Copper;Coupled;Culture Media;Data;Deficiency Diseases;Development;Developmental Process;Differentiation Antigens;Disease;Dystonia;Enzymes;Excretory function;expectation;experimental study;Failure;Family;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genomic DNA;genomic locus;Growth;Health;Hepatolenticular Degeneration;Homeostasis;Human;Hydroxyl Radical;Hypertrophic Cardiomyopathy;Immunoprecipitation;Impairment;in vivo;Ions;iron absorption;knock-down;Knock-out;Knowledge;Life;Location;Mass Spectrum Analysis;Menkes Kinky Hair Syndrome;Metabolism;Metals;Mitochondria;Modeling;Modification;Molecular;Molecular Chaperones;mouse model;Mus;Muscle;Muscle Development;Muscle hypotonia;Muscle satellite cell;Mutation;Myoblasts;myogenesis;Myogenin;Myopathy;Neurologic;Neutropenia;novel;Organ;Pathologic;Pathology;Patients;Peptide Sequence Determination;Peripheral Nervous System Diseases;Phenotype;Play;posttranscriptional;prevent;programs;Proliferating;Proliferation Marker;promoter;Property;Proteins;recruit;Regulation;Role;Skeletal Muscle;skeletal muscle differentiation;Specific qualifier value;Study models;Techniques;Testing;Time;Tissue Differentiation;Tissue-Specific Gene Expression;Tissues;Trace Elements;Trace metal;transcription factor;Transcriptional Regulation;transcriptome sequencing;Western Blotting

PROJECT_TITLE: Mechanisms of Cu-binding factors to promote myogenic gene expression

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Cystic Fibrosis;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative: Infections associated with cystic fibrosis, and other polymicrobial infections, are still a significant cause of morbidity and mortality. Here we propose to apply bioinformatics, modeling and experimental tools to a large clinical data set to gain new insight into how to treat complex, chronic polymicrobial infections.

PI_NAMEs: O'TOOLE, GEORGE A. (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute;Acute Disease;anti-microbial drug;antibiotic tolerance;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;bacterial community;Big Data;Bioinformatics;bioinformatics tool;Cell Culture Techniques;Chronic;Chronic Disease;Clinical;Clinical Data;Communities;Complex;Computer Models;Consumption;Culture-independent methods;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis infection;cystic fibrosis patients;Data;Data Set;Development;Disease;Disease Outcome;Dose;Energy-Generating Resources;Event;Exhibits;Experimental Models;experimental study;Exposure to;feeding;Feeding Patterns;Genetic Diseases;Genetic study;improved;in silico;In Vitro;in vitro Model;in vivo;Individual;Infection;insight;Lung;Lung infections;Machine Learning;Measures;member;Metabolic;metabolomics;Metadata;Microbe;microbial community;Microbial Physiology;Minimum Inhibitory Concentration measurement;Modeling;Morbidity - disease rate;mortality;Mucous body substance;Mutation;Nature;novel;novel therapeutics;Organism;Outcome;Output;pathogenic bacteria;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;polymicrobial biofilm;polymicrobial disease;poor communities;Production;Prognosis;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pulmonary Cystic Fibrosis;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;Regimen;Research;Resistance;Role;Sampling;Sputum;Staphylococcus aureus;Streptococcus;Structure;success;Testing;tool;translational impact;treatment response;Virulence;Work

PROJECT_TITLE: Metabolic Basis of Bacterial Community Function in the Cystic Fibrosis Airway

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Most patients with type 2 diabetes (T2D) in Benin have difficulty adjusting their diet to reach their target glycated hemoglobin level (HbA1c), increasing their risk of complications. Through training and research activities, a culturally tailored medical nutrition therapy (MNT) will be used to improve dietary adherence and health outcomes, thus reducing the disease burden of this high-risk population. If successful, this study may be included in future multi-component self-management interventions and be of immediate benefit to clinics.

PI_NAMEs: ALAOFE, HALIMATOU  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Adherence;adherence rate;Adoption;Africa;African;Area;Award;Behavior;Behavior Therapy;Behavioral Sciences;blood glucose regulation;burden of illness;Canada;Carbohydrates;cardiovascular risk factor;care delivery;career development;Caring;Chronic Disease;Clinic;Collaborations;Collection;Combined Modality Therapy;Complement;cost effectiveness;Counseling;Country;Data;Death Rate;design;Development;diabetes control;diabetes management;Diabetes Mellitus;Diet;Diet Modification;dietary;dietary adherence;Dietitian;disability;Disease;effectiveness testing;efficacy evaluation;empowerment;Epidemic;Family;Focus Groups;Food;Foundations;Future;glycemic control;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;good diet;Grant;Guidelines;Health;Health Food;Health Personnel;Healthcare Systems;Hemoglobin concentration result;high risk population;improved;Individual;innovation;International;Intervention;intervention cost;intervention delivery;Intervention Trial;Interview;Knowledge;Linear Programming;Low income;Low Income Population;Medical Nutrition Therapy;men;Mentored Research Scientist Development Award;Mentors;Mentorship;Menu Planning;Methods;Modeling;Modification;Monitor;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Non-Insulin-Dependent Diabetes Mellitus;nutrition;nutrition education;Nutrition management;Nutrition Therapy;Obesity;Outcome;Outcome Study;patient oriented research;Patients;Persons;Population;Population Characteristics;Positioning Attribute;Prevalence;prevent;programs;protein intake;Publications;Qualitative Methods;Randomized;Randomized, Controlled Trials;Recipe;Recommendation;recruit;Reporting;Research;Research Activity;Research Design;Research Methodology;Resource-limited setting;Risk;satisfaction;Self Management;Social Sciences;Societies;stem;System;Target Populations;Testing;Therapeutic Intervention;Time;Training;Training Activity;Translating;usual care arm;Weight;Woman;Work

PROJECT_TITLE: Culturally Tailored Nutrition Therapy To Improve Dietary Adherence of Type 2 Diabetes Patients in Benin, Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-G(55)R]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: DERMATOLOGY

PHR: REGULATION OF SKIN HOMEOSTASIS BY RNA-BINDING PROTEINS  Project Narrative The maintenance of epithelial tissue is orchestrated by an interplay of regulatory factors that control transcription, RNA processing, translation and protein modification that together balance the decisions to divide, differentiate or enter senescence. Breakdowns in this regulatory system lead to skin diseases, such as psoriasis or cancer. This proposal aims to understand the roles of RNA-binding proteins and their modification in epidermal homeostasis in mechanistic detail.

PI_NAMEs: PORTER, DOUGLAS F (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Affect;Affinity;American;Arginine;arginine methyltransferase;Binding;Binding Proteins;Bioinformatics;Biology;career;Cell Nucleolus;Cells;Chromatin;Code;Complex;cost;crosslinking and immunoprecipitation sequencing;Data;Data Set;Defect;Dermatology;design;dimer;Dimerization;DNA-Directed RNA Polymerase;Environment;Epithelium;Equilibrium;Exhibits;Exons;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Healthcare;helicase;histone modification;Histones;Homeostasis;Homo;Impairment;In Vitro;in vivo;Incidence;interest;keratinocyte;keratinocyte differentiation;Knock-out;Lead;Machine Learning;Maintenance;Malignant Neoplasms;Mediating;Messenger RNA;method development;Methylation;Methyltransferase;Modeling;Modification;mRNA Precursor;Nuclear;Nucleolar Proteins;Nucleoplasm;Phenotype;Phosphorylation;Post Translational Modification Analysis;Post-Translational Protein Processing;premature;Production;progenitor;Proliferating;Protein Biochemistry;Protein Methylation;Proteins;Proteomics;Protocols documentation;Psoriasis;Regulation;Repression;Research;Ribosomal RNA;RNA;RNA Binding;RNA Helicase;RNA methylation;RNA Processing;RNA Splicing;RNA Stability;RNA-Binding Proteins;Role;Scientist;senescence;skills;Skin;skin disorder;statistics;Surveys;System;Testing;Thinness;Tissues;Training;transcription factor;Transcriptional Regulation;Translations;Virus Replication

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Heart Disease;Infectious Diseases;Lung;Prevention

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE SARS-CoV-2 infection can cause extensive and lasting damage to the lungs and heart. We are investigating the mechanisms by which the noncanonical inflammasome promotes excessive inflammation and thrombosis in these organs, including in the context of specific immunodeficiencies linked to severe COVID-19. Our work will provide new fundamental understanding of COVID-19 disease pathogenesis, and will identify new host- directed therapeutic strategies.

PI_NAMEs: AMER, AMAL O;YOUNT, JACOB  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 2019-nCoV;Amplifiers;angiogenesis;antiviral immunity;Autoantibodies;Biology;Blood Vessels;Body Weight decreased;Brain;Cardiac;CASP4 gene;Caspase;Cell Death;cell type;Cells;Chemicals;chemokine;combat;COVID-19;COVID-19 morbidity;COVID-19 patient;COVID-19 prevention;COVID-19 severity;COVID-19 treatment;CXCL1 gene;cytokine;cytokine release syndrome;Disease;experience;Generations;Genetic;Genetic Polymorphism;Health;Heart;heart damage;Heart Diseases;Human;Immune;immune activation;Immune Targeting;Immunocompetent;immunodeficiency;Immunology;Infection;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Infiltrate;inhibitor;Integral Membrane Protein;interferon alpha receptor;Interferon Type I;Interferons;Knock-out;Knockout Mice;Link;LoxP-flanked allele;Lung;Lung Diseases;Lung infections;lung injury;Mediating;migration;Modeling;Molecular;mortality;mouse model;multiorgan damage;Mus;Myocardial dysfunction;Natural Immunity;neutralizing antibody;neutrophil;Neutrophil Infiltration;Organ;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Population;Positioning Attribute;Predisposition;prevent;Primary Cell Cultures;Production;Proteins;Pulmonary Pathology;pulmonary vascular remodeling;recruit;Research Personnel;respiratory;Risk Factors;risk variant;Role;Sampling;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;severe COVID-19;Signal Transduction;Swab;System;systemic inflammatory response;Testing;Therapeutic;therapeutic target;Therapeutically Targetable;Thrombosis;Tissues;Vaccines;Variant;Vascular Endothelium;Viral;viral entry inhibitor;virology;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Mechanisms of lung and cardiac pathology in SARS-CoV-2 infections

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

PHR: Narrative The heart rhythm disorders of ventricular arrhythmias affect hundreds of thousands of individuals in the U.S. alone and are substantial causes of mortality, yet their therapy is suboptimal. A major problem is that it is difficult to identify which patient will respond to drug or ablation therapy. This project will develop a computer-based framework to personalize therapy for ventricular tachycardia, using machine learning and personalized computer models.

PI_NAMEs: NARAYAN, SANJIV M (contact)

PROJECT_TERMS: Ablation;Affect;Age;Anti-Arrhythmia Agents;Area Under Curve;Basic Science;Big Data;Biological;Biomedical Engineering;Caring;Classification;Clinical;Clinical Data;clinical imaging;clinical phenotype;clinical predictors;Clinical Sciences;Clinical Trials;Combined Modality Therapy;comorbidity;complex data;computational pipelines;Computer Models;Computers;Data;Data Science;Data Set;data visualization;Databases;Diabetes Mellitus;Diagnostic;Diffusion;Disease;diverse data;Dizziness;Electrophysiology (science);FAIR principles;Fiber;Fibrosis;Gadolinium;Genetic;Genomics;Heart;Heart Arrest;heart rhythm;Hospitalization;Image;improved;improved outcome;Individual;individual patient;Institution;Intelligence;Interruption;Label;Laboratories;Learning;Lesion;Life;Machine Learning;machine learning prediction;Magnetic Resonance;Magnetic Resonance Imaging;Methods;Modeling;mortality;Natural Language Processing;non-invasive imaging;novel;Patients;personalized medicine;Pharmaceutical Preparations;Physicians;Physics;Population;Population Sciences;predicting response;predictive modeling;Predisposition;prevent;Recurrence;Registries;response;Risk;statistics;Strategic Planning;structural determinants;success;Syncope;Testing;tool;Training;Translational Research;United States;United States National Institutes of Health;Ventricular Arrhythmia;Ventricular Fibrillation;Ventricular Tachycardia

PROJECT_TITLE: Machine Learning for Ventricular Arrhythmias

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: MH

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE This project will investigate the properties of generalization in neural networks, using abstract sequence representation. Such sequences are necessary in daily life, and their neural underpinnings remain unknown. These results will provide a foundation for explicating and addressing the neural mechanisms behind impaired sequence processing and generalization in conditions such as Obsessive-Compulsive Disorder.

PI_NAMEs: CONEN, KATHERINE E (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Address;Affect;awake;Behavior;Behavioral;blood oxygen level dependent;career;Case Study;Chronic;Code;Communication;Communities;Commuting;Computer Models;computing resources;Data;Data Set;Development;Dimensions;Educational workshop;Electrodes;Electrophysiology (science);Environment;Event;experimental study;flexibility;Foundations;frontal lobe;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Human;human disease;human model;Impairment;in silico;interest;Knowledge;Lateral;Life;Link;Macaca;Maps;Mediating;Medical emergency;meetings;Mentorship;Methods;Modeling;Monitor;Monitoring for Recurrence;Monkeys;multi-electrode arrays;neural;neural network;Neurologic;neuromechanism;Neurons;neuropsychiatric disorder;Neurosciences;nonhuman primate;Obsessive-Compulsive Disorder;Outcome;Output;Parkinson Disease;Pattern;Performance;Population;Positioning Attribute;Prefrontal Cortex;Preparation;Primates;Property;Ramp;Recording of previous events;recurrent neural network;Research;research facility;Research Project Summaries;response;Response to stimulus physiology;Sampling;sensory stimulus;Series;Source;Stimulus;Structure;Symptoms;System;Testing;Training;Work

PROJECT_TITLE: Neural Representations of Abstract Sequences


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The communication between gene promoters and distal enhancers is essential for proper cell function, while often aberrant enhancer function leads to transcription deregulation and disease, however how enhancers target specific promoters remains unknown. This project will leverage new optical imaging technologies to directly visualize, with molecular detail, the dynamics of enhancer-promoter communication and downstream gene transcription control, in the nucleus of single live mammalian cells. A better understanding of the relation between genome organization and gene expression regulation will provide new opportunities for therapeutic and preventive interventions.

PI_NAMEs: PERTSINIDIS, ALEXANDROS  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 3-Dimensional;4D Imaging;Acute;Adopted;Adult;Architecture;Award;Base Pairing;Binding;Biochemical;Biochemistry;Biology;Biophysical Process;biophysical techniques;Biophysics;Cell Communication;cell fixing;Cell Nucleus;Cell Physiology;cell type;Cells;cellular engineering;Chromatin;Chromatin Loop;cohesin;Communication;Complex;CRISPR interference;Crowding;Cues;Data;Development;differential expression;Disease;Distal;Distant;DNA;DNA Polymerase II;Elements;Embryo;Enhancers;Ensure;Environment;Frequencies;Gene Expression;Gene Expression Regulation;Genes;Genetic Enhancer Element;Genetic Transcription;Genome;genomic locus;Genomics;Goals;Health;Human;human disease;Image;imaging capabilities;imaging modality;Imaging Techniques;Imaging technology;Individual;Kinetics;Knowledge;live cell imaging;Mammalian Cell;Mediating;Messenger RNA;Methodology;Methods;Modeling;Molecular;Monitor;nonbinary;novel;novel strategies;Nuclear Structure;Oncogene Deregulation;optical imaging;Physics;Polymers;Positioning Attribute;preventive intervention;Process;Production;programs;promoter;Proteins;Regenerative Medicine;Regulation;Regulatory Element;Resolution;RNA Polymerase II;Role;Shapes;Signal Transduction;single molecule;spatiotemporal;Specific qualifier value;Structure;superresolution imaging;System;Testing;Therapeutic;Therapeutic Intervention;Time;transcription factor;Transcriptional Activation;Transcriptional Regulation;ultra high resolution;Validation;Visualization;Work;YY1 Transcription Factor

PROJECT_TITLE: Mechanisms of enhancer-promoter communication, genome organization and transcription control

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurosciences;Stroke;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE The proposed research is relevant to the public health because stroke is the leading cause of disability in both sexes. Women have higher incidence of stroke, worse functional outcomes, and are less likely to be discharged to their home after hospitalization at an older age. Upon completion, we will understand the role of interleukin-6 trans-signaling in older stroke subjects, and this discovery will stimulate the development of efficacious therapies to improve long-term functional recovery in older women after stroke.

PI_NAMEs: CHAUHAN, ANJALI  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Age;aged;Aging;aging brain;Alzheimer's Disease;Androgens;Anti-Inflammatory Agents;behavioral study;Binding;Biological;Biological Factors;Blocking Antibodies;Brain;Cell Nucleus;cell type;Cells;cerebral atrophy;Cerebrum;Chromatin;cognitive function;Complex;cytokine;Data;dementia risk;Development;disability;Dissociation;Dose;efficacious treatment;Elderly;Enzyme-Linked Immunosorbent Assay;Estrogens;Euthanasia;Exposure to;Female;Flow Cytometry;Fluorescence;Four Core Genotypes;functional improvement;functional outcomes;Genes;glial activation;Goals;Gonadal Steroid Hormones;Hepatocyte;High Risk Woman;Home;Hospitalization;Hour;Human;human old age (65+);IL-6 inhibitor;IL6 gene;IL6ST gene;Immune response;Impaired cognition;improved;Infarction;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;innovation;insight;Interleukin 6 Receptor;Interleukin-6;Ischemic Stroke;JAK2 gene;Knock-out;knockout animal;Ligands;Lymphocyte;Macrophage;male;Mediating;Membrane;men;Messenger RNA;Microglia;Middle Cerebral Artery Occlusion;Molecular;monocyte;Motor;mRNA Expression;Mus;neuroinflammation;neutrophil;old mice;older women;Outcome;Ovary;ozone exposure;Pathology;Pathway interactions;Patients;Phenotype;Play;Ploidies;post stroke;preclinical study;Public Health;receptor;receptor binding;receptor expression;Receptor Signaling;Recovery of Function;Research;RNA Splicing;Role;secretory protein;Severities;sex;Sex Chromosomes;Sex Differences;Signal Pathway;Signal Transduction;Sorting;STAT3 gene;Stroke;stroke incidence;stroke outcome;stroke patient;T cell infiltration;targeted treatment;Testing;Testis;Therapeutic;tocilizumab;transcriptome sequencing;vascular cognitive impairment and dementia;Western Blotting;Woman;women versus men;X Chromosome;XCL1 gene

PROJECT_TITLE: Contribution of IL6 trans signaling in older females after ischemic stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Complementary and Integrative Health;Diabetes;Dietary Supplements;Digestive Diseases;Microbiome;Nutrition;Obesity;Prevention

ORG_DEPT: SURGERY

PHR: Narrative Obesity and type 2 diabetes remain unmet medical needs that exact enormous human and monetary costs. While we know that many organ systems are involved in the pathology of these conditions, the gastrointestinal tract has become the source of our best treatment tools and this includes surgical manipulation of the gastrointestinal tract. This proposal aims to reverse engineer the potent benefits of surgical treatments for obesity and type 2 diabetes to identify treatment strategies that are less invasive and more scaleable so as to be able to better treat and/or prevent these diseases.

PI_NAMEs: SEELEY, RANDY J (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: absorption;Affect;anti-microbial peptide;Bacteria;bariatric surgery;Biology;blood glucose regulation;Body fat;Body System;Body Weight;Calories;Cellular Stress;Central Nervous System;Circulation;Communication;Data;Development;Diabetes Mellitus;Diet;dietary;dietary supplements;Disease;effective therapy;energy balance;Financial cost;Functional disorder;Gastrectomy;Gastric Emptying;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal Hormones;Gastrointestinal tract structure;Glucose;glucose metabolism;glucose tolerance;gut health;gut microbiome;gut microbiota;High Fat Diet;Hormones;Human;improved;in vivo Model;Inflammation;insulin secretion;Intervention;intestinal barrier;Intestines;Inulin;Knockout Mice;Lactobacillus;Mediator;Medical;Metabolic;Metabolic Diseases;Metabolism;Metformin;Mucous body substance;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nutrient;Obesity;obesity management;obesity treatment;Operative Surgical Procedures;Oral Administration;Organoids;Outcome;Oxidative Stress;Paneth Cells;Pathology;pharmacologic;Pharmacological Treatment;Pharmacology;Prevalence;prevent;Probiotics;Production;reduced food intake;Regenerating islet derived protein 3-Gamma;Regenerative capacity;Regulation;response;Reverse engineering;Role;segregation;Signal Transduction;Small Intestines;soluble fiber;Source;Testing;Tight Junctions;tool;Toxin;treatment strategy;Work

PROJECT_TITLE: Intestinal Reg3g as a mediator of dietary, pharmacological and surgical therapies for obesity and diabetes

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: CE

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: AMES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: IOWA STATE UNIVERSITY

PHR: Narrative The proposed study will use a randomized controlled trial design to evaluate the potential of incorporating physical therapy exercises (primary prevention strategy) within an evidence-based intervention called Walk with Ease to reduce falls and fall risk in older, community-dwelling older adults. The integrated process and outcome evaluation will determine the relative effectiveness of individually prescribed exercises (compared to standardized exercises) as well as the potential of formalized ‘habit training’ to improve compliance with exercises in this population. The study, conducted through a local clinical / community partnership will advance both science and practice while also informing implementation strategies needed to promote broader dissemination in collaboration with the CHPcommunity and the Iowa Falls Prevention Coalition.

PI_NAMEs: WELK, GREG J (contact)

PROJECT_TITLE: CE-22-006 Process and Outcome Evaluation of the Walk with Ease program for Fall Prevention


ORG_NAME: NATIONAL OPINION RESEARCH CENTER

PHR: PROJECT NARRATIVE The proposed research is highly relevant to public health due to its potential to advance research and prevention efforts by documenting risk and protective factors associated with indirect (witnessing) and direct (gun carrying and perpetration and victimization) firearm violence experienced by youth and young adults in the United States, increasing our ability to understand and interrupt the cycle of firearm violence and decrease the risk of injury and death. Importantly, the study’s three-wave longitudinal design will allow for the identification of modifiable risk and protective factors for firearm violence at the individual, family, peer, school/work, and community levels. We expect results from this study to inform prevention work which will, in turn, reduce mortality, improve quality of life, and reduce medical costs associated with firearm violence.

PI_NAMEs: MITCHELL LEMA, KIMBERLY J;TAYLOR, BRUCE GREGORY (contact)

PROJECT_TITLE: RFA-CE-22-004, Firearm Violence Perpetration: A Nationally Representative Multi-Wave Survey of Youth and Young Adults Across the United States


ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE  Drowning is a leading cause of unintentional injury death with significantly higher drowning rates occurring in persons belonging to minority groups. The proposed project will identify gender and ethnic subpopulations that experience higher rates of unintentional drowning, investigate the causes and outcomes for these disparities and compute the economic costs arising from unintentional drowning. Our research will help understand conditions affecting morbidity and mortality from unintentional drowning, especially in subpopulations that experience higher rates of drowning.

PI_NAMEs: SHENOI, ROHIT  (contact)

PROJECT_TITLE: CE-22-008 ASTRAL (Aquatic Safety Through Research, Association, and Linkage of Data)


ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative The proposed study will examine the short- and long-term effects of vacant lot reuse as a strategy for preventing community violence in Indianapolis, IN, a city with elevated rates of violent crime. The study will test whether higher levels of implementation and community engagement enhance preventive effects of vacant lot reuse on violence through site surveys and in-depth case studies of effective reuse efforts.

PI_NAMEs: HEINZE, JUSTIN EDWARD (contact);WANG, LU

PROJECT_TITLE: Community violence prevention through community-engaged vacant property reuse: Longitudinal application of Busy Streets Theory in Indianapolis


ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Suicide accounts for 60% of firearm deaths in the U.S. and most people who die by suicide see a health care provider in the year prior to death. Though firearm access is relevant to patients’ health and safety, gun ownership is often a contentious and polarizing issue and there is a dearth of evidence available to guide implementation of clinical practices for identifying and engaging patients at high-risk of firearm suicide. To address this gap, researchers embedded in three healthcare systems, serving sociodemographic diverse communities with high rates of firearm ownership, will partner with leaders, clinicians, and patients to design and test intervention strategies using an innovative Human-Centered Design approach.

PI_NAMEs: ANGERHOFER, JULIE ELISSA (contact)

PROJECT_TITLE: RFA-CE-22-004, Optimizing Firearm Suicide Prevention in Healthcare


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Prevention;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: RELEVANCE TO PUBLIC HEALTH Breast cancer is the world’s most prevalent cancer, with 2.3 million women diagnosed and 685,000 deaths globally in 2021. While breast cancer maintains a chokehold on women’s health, the death rate has declined by about 1% per year over the last decade due in large part to earlier detection. The goal of this work is to develop a new, noninvasive, ultrasound-based imaging technology that expands understanding of breast cancer pathophysiology and improves breast cancer diagnosis and treatment monitoring.

PI_NAMEs: GALLIPPI, CATERINA M (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Acoustics;Adjuvant Chemotherapy;Adverse effects;Anisotropy;Benign;Biological Markers;Biopsy;Breast;breast cancer diagnosis;cancer biomarkers;Cancer Detection;cancer diagnosis;cancer therapy;cancer type;Cessation of life;Clinical;clinically relevant;Collagen;Collagen Fiber;Complex;contrast enhanced;cost;Custom;Data;Data Collection;Death Rate;Dependence;Development;Diagnosis;Diagnostic Neoplasm Staging;Diagnostic Sensitivity;Digital Breast Tomosynthesis;Digital Mammography;Disease Progression;Early Diagnosis;elastography;Feasibility Studies;Functional disorder;Goals;histological studies;Imaging technology;improved;In complete remission;in silico;in vivo;interest;Investigation;Learning;Lesion;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Manuals;Mass in breast;Measurement;Monitor;Neoadjuvant Therapy;Neoplasm Metastasis;Outcome;Pathologic;Patients;Pattern;Performance;Prognosis;Public Health;Radiation;Radiation Dose Unit;radiological imaging;Reporting;response;restraint;screening;Sensitivity and Specificity;Specificity;Stress;success;Technology;Tissues;treatment response;trend;ultrasound;viscoelasticity;Woman;women's diagnosis;Women's Health;Work

PROJECT_TITLE: VisR Ultrasound for Noninvasively Interrogating Stromal Collagen Organization in Women as a Breast Cancer Biomarker

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-J(03)M]


ORG_CITY: SPRINGFIELD

ORG_NAME: SPRINGFIELD COLLEGE

PHR: Narrative Falls are the leading cause of injury in adults over age 65. Muscle weakness in the foot can lead to foot and toe deformities such as collapsed arches or bunions, which have been found to contribute to falls in adults over age 65. The current research study aims to investigate the effectiveness of two simple and affordable foot strengthening methods that may make a major impact on balance and fall prevention in older adults.

PI_NAMEs: FUTRELL, ERIN  (contact)

PROJECT_TITLE: CE-22-006 The effects of intrinsic foot muscle strengthening interventions on balance, proprioception, and fall risk in adults over age 65


ORG_NAME: SEATTLE-KING COUNTY PUBLIC HEALTH DEPT

PHR: New Opportunities for Health and Resilience Measures for Suicide (NO HARMS) Prevention Project Narrative Suicide is an increasingly urgent public health issue, nationally and in King County, Washington; the risk and protective factors for suicide death and intentional self-harm are complex and vary by life experiences, demographics, and overarching social determinants of health. Using data to understand these complexities and inform effective suicide prevention strategies requires looking across a wide variety of datasets spanning healthcare, mental health and substance use services, the criminal legal system, housing and homelessness, emergency and crisis services, and community-level information sources. We propose an innovative and replicable data linkage project, New Opportunities for Health and Resilience Measures for Suicide (NO HARMS) Prevention, that connects 12 datasets and subject matter experts across these topics and constructs data elements to analyze individual and community risk and protective factors as well as system touchpoints for a comprehensive examination of suicide and intentional self-harm in King County.

PI_NAMEs: MATHESON, ALASTAIR  (contact)

PROJECT_TITLE: CE-22-008 Using Data Linkage to Understand Suicide Attempts, Self-Harm and Unintentional Drowning Deaths


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Physical Activity;Prevention

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Adults in developed nations are sedentary for nearly two-thirds of the day- often for hours at a time- which greatly increases risk for cardiovascular disease and mortality. The Physical Activity Guidelines for Americans have recently expanded beyond promoting moderate-vigorous intensity physical activity and now also advocate for reductions in sedentary time; however due to a paucity of evidence only general recommendations (“sit less, move more”) have been provided without any specific, quantitative, actionable targets. This adaptive dose finding study will determine how often and for how long people should break up periods of prolonged sedentary time to transiently improve established cardiovascular risk factors; key foundational information critical to the success of future long-term trials and ultimately public health guidelines.

PI_NAMEs: CHEUNG, KEN ;DIAZ, KEITH M (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Address;Adult;adverse outcome;Advisory Committees;Advocate;Affect;American;American Heart Association;Behavioral trial;Blood Glucose;Blood Pressure;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cohort Studies;Data;Developed Countries;Development;Diastolic blood pressure;Dose;dose information;Effectiveness;Elements;Emotions;energy balance;Epidemic;evidence base;evidence based guidelines;exhaustion;Exhibits;experimental study;Fatigue;Foundations;Frequencies;Future;Glucose;Guidelines;Health;Health Benefit;Hour;Hypoglycemia;improved;innovation;Interruption;Intervention;Laboratories;Link;Maximum Tolerated Dose;Measures;Methods;Moods;Morbidity - disease rate;mortality;Outcome;Participant;Performance;Persons;Phase;phrases;Physical activity;Process;Protocols documentation;psychological distress;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Risk;Risk Factors;Safety;sedentary;sedentary lifestyle;Smoking;Standardization;Strenuous Exercise;success;Testing;therapy development;Time;uptake;vigorous intensity;Visit;Walking;Work

PROJECT_TITLE: Breaking up Prolonged Sedentary Behavior to Improve Cardiometabolic Health: An Adaptive Dose-Finding Study

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE The observation that halogen atoms decorate numerous pharmaceuticals and potent environmental pollutants makes advancing halogenation biochemistry critically important for human and environmental health. This proposal takes an integrated biological and chemical approach to discover, characterize, and engineer the biogenetic routes for the construction of bioactive halogenated molecules from marine eukaryotes that are well validated to be the richest resource of halogenated organic molecules. Metagenomic and transcriptomic workflows will be used to identify genes and enzymes responsible for constructing halogenated molecules in complex eukaryotic holobionts, activities of halogenating enzymes characterized, and novel halogenated molecules evaluated for favorable bioactivities.

PI_NAMEs: AGARWAL, VINAYAK  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Halogenation Biochemistry in Human and Environmental Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative  This project will develop the m6A-Suite informatics pipeline and the m6A-KB knowledgebase to enable global and unbiased delineation of the mechanistic roles of m6A epitranscriptome in cancer. m6A-Suite and m6A-KB address the unmet informatics needs for bridging the knowledge gaps in our understanding of m6A’s roles in cancer biology. They will have a transformative impact on m6A research and provide insights into m6A-based therapeutics.

PI_NAMEs: HUANG, YUFEI  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Acceleration;Address;algorithm training;Algorithms;Alternative Splicing;anti-cancer research;Area;base;biomarker identification;Cancer Biology;cancer cell;Cancer cell line;Catalogs;Cell Line;Cells;Collaborations;Collection;Communities;Consumption;Data;Data Set;Databases;design;Detection;differential expression;Drug Targeting;Ensure;epitranscriptome;Feedback;Gene Expression;Gene Expression Regulation;Growth;Human;Human Herpesvirus 8;improved;In Vitro;in vivo;Informatics;informatics tool;insight;Knowledge;knowledgebase;Link;Malignant Neoplasms;Mammalian Cell;Maps;Mediating;Messenger RNA;Metabolism;Methylation;Modality;Modeling;Modification;mRNA Decay;mRNA Stability;multimodality;Mus;nanopore;Nature;Normal Cell;Normal tissue morphology;Oncogenic Viruses;Oncologist;open data;open source;Pathway interactions;Pattern;Performance;Phenotype;Physiological Processes;Play;predictive tools;programs;Proteins;Reader;Research;Resolution;Resources;RNA;RNA Decay;RNA Splicing;Role;Sampling;self supervised learning;sequence learning;Shapes;Signal Transduction;Site;Testing;Therapeutic;therapeutic biomarker;Tissues;tool;Training;training data;Tumor Tissue;usability;Viral;Work

PROJECT_TITLE: m6A-suite: an informatics pipeline and resource for elucidating roles of m6A epitranscriptome in cancer


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PHR: Although our understanding of disease biology as it relates to the central dogma (DNA-RNA-Protein) has been buoyed by rapid technological advances in DNA and RNA sequencing technologies, quantitation of the final and arguably most actionable element of the central dogma, protein, has lagged behind. In this proposal, we will develop cutting-edge, mass spectrometry-based proteomic technologies, and combine them with biochemical, cell biology and animal experiments to study various protein posttranslational modifications (in particular, phosphorylation and ADP-ribosylation) that are related to cell growth control and stress responses. In so doing, we will uncover signaling mechanisms that will lead to better therapeutic intervention strategies for the treatment of relevant human diseases.

PI_NAMEs: YU, YONGHAO  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: ADP ribosylation;Animal Experiments;Atlases;Biochemical;biological adaptation to stress;Biology;cell growth;cell growth regulation;Cells;Cellular biology;Cellular Stress;cellular targeting;Chemicals;Collection;Complex;Disease;DNA;DNA sequencing;Elements;Event;extracellular;Feedback;FRAP1 gene;Genetic Transcription;Genome;Goals;Human;human disease;IGFBP5 gene;improved;innovation;Link;Mass Spectrum Analysis;Measures;Mediator;Methods;Mission;Molecular;novel;Pathologic;Pathway interactions;Performance;Phosphorylation;Physiology;Post-Transcriptional Regulation;Post-Translational Protein Processing;Post-Translational Regulation;Process;programs;Protein Analysis;Proteins;Proteome;Proteomics;Reagent;RNA;Role;Signal Transduction;Site;stoichiometry;Systems Biology;Technology;Therapeutic Intervention;Tissues;trait;transcriptome sequencing;treatment strategy

PROJECT_TITLE: Posttranslational Regulation of Cell Growth and Stress Responses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE: The study of genetic skin disorders, including disorders of keratinization, has identified many pathways central to the normal function of the skin. We propose to employ exome and genome sequencing technologies to identify the remaining genetic causes of these disorders. This work will benefit public health, as gaining insight into genetic causes of these diseases will provide new information about how the skin maintains and renews itself, and may serve as the basis for creating new approaches to targeted therapy for both these rare disorders and related, more common, disorders within the population.

PI_NAMEs: CHOATE, KEITH A (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Affect;Area;Artificial skin;assault;Biochemical;Biological;Biological Assay;Biology;Bulla;Cells;Chemicals;Childhood;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;comorbidity;Complex;cost;CRISPR/Cas technology;Cutaneous;Data;Dermatology;Disease;disease phenotype;disorders of keratinization;Enrollment;Epidermis;Epithelium;Etiology;Exclusion;exome sequencing;experience;experimental study;Foundations;Funding;Future;gain of function;gene discovery;gene function;Gene Modified;Generations;Genes;Genetic;Genetic Determinism;genetic disorder diagnosis;Genetic study;genetically modified cells;genome editing;genome sequencing;Heat Losses;Hereditary Disease;Heritability;Heterogeneity;Heterozygote;Ichthyosis Vulgaris;In Vitro;in vivo Model;indexing;Individual;Infant;Infection;insight;Investigation;keratinocyte;kindred;Knock-in;Knock-out;Late-Onset Disorder;Life;loss of function;Mechanics;Medical Records;Metabolic;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mutation;mutation screening;next generation sequencing;Normal tissue morphology;novel;novel strategies;pachyonychia congenita;Palmoplantar Keratosis;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Physicians;Physiology;Population;Predisposition;prevent;Process;Proteins;Public Health;Rare Diseases;reconstitution;recruit;Reflex action;Research;Resources;screening panel;self-renewal;Site;Skin;skin disorder;Surface;targeted treatment;Technology;Tissues;Transgenic Organisms;treatment response;Variant;viral gene delivery;Water;Work;X-Linked Ichthyosis

PROJECT_TITLE: Genetics and Pathobiology of Disorders of Keratinization

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Cancer patients have immune cells that potentially can attack the tumor. Knowing if these immune cells are present around the tumor provides a way of predicting the patient’s prognosis – however, there are no standardized ways of determining this information from patient’s biopsies. Our project addresses this challenge through a new computational method that analyzes microscopic images of a patient’s cancer and characterize immune cells in much higher resolution compared to what is done by pathologists.

PI_NAMEs: JI, HANLEE P (contact)

PROJECT_TERMS: Address;Architecture;Area;automated analysis;Biopsy;Brain;cancer genomics;cancer imaging;cancer immunotherapy;Cancer Patient;cancer type;cell type;Cells;Characteristics;Classification;Clinical;cohort;computer framework;Computing Methodologies;Consumption;convolutional neural network;Data;data exchange;Data Set;deep learning;deep learning model;digital;Disease;Endothelial Cells;Epithelium;Evaluation;Fibroblasts;Gene Expression;genomic data;Genomics;geometric structure;Guidelines;Head and Neck Cancer;Hematoxylin and Eosin Staining Method;Histopathology;Image;Image Analysis;imaging modality;imaging system;Immune;immune checkpoint;immune checkpoint blockade;Immune response;Immunohistochemistry;Immunologic Markers;Immunotherapy;innovation;insertion/deletion mutation;Joints;Label;Learning;Lung;Lymphocyte;Macrophage;Malignant Neoplasms;Manuals;Maps;Measures;Methods;microscopic imaging;Modeling;Molecular;molecular marker;multiplexed imaging;Mutation;neoantigens;nonsynonymous mutation;Observer Variation;Outcome;Pathologic;Pathologist;Pathology;pathology imaging;patient prognosis;Patients;Performance;Phenotype;Population;Predictive Value;Procedures;prognostic value;Proxy;Regional Cancer;Reproducibility;Research;Resolution;response;Sampling;Spatial Distribution;spatial relationship;Stains;Standardization;Structure;Testing;The Cancer Genome Atlas;Time;Tissue Fixation;Training;training data;tumor;tumor heterogeneity;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Validation

PROJECT_TITLE: Integrating cancer genomics and spatial architecture of tumor infiltrating lymphocytes

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHARLESTON

ORG_DEPT: PATHOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: PROJECT NARRATIVE Pericyte dysfunction results in decreases in cerebral blood flow and disruption of the blood brain barrier, which contribute to Alzheimer’s disease (AD) development. The goals of this proposal are to gain a deep understanding of the role of Fli-1 in regulating pericyte dysfunction in AD and to develop a novel treatment strategy for AD.

PI_NAMEs: FAN, HONGKUAN  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta accumulation;Address;Age Months;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Animals;Antisense Oligonucleotides;Apoptosis;arterial spin labeling;Astrocytes;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood capillaries;Blood Vessels;blood-brain barrier disruption;Brain;brain pericytes;Brain region;brain tissue;CASP1 gene;CASP3 gene;Cell Adhesion Molecules;Cells;cerebral capillary;cerebrovascular amyloid;Cerebrovascular Circulation;Cessation of life;clinically relevant;comparison control;Cytometry;Data;Deposition;design;Development;Disease Progression;Endothelial Cells;Enzyme-Linked Immunosorbent Assay;Extravasation;FLI1 gene;FLI1 Transcription Factor;Functional disorder;Goals;Hippocampus;Histological Techniques;Human;hypoperfusion;Image;Imaging Techniques;Impaired cognition;Impairment;In Situ Nick-End Labeling;in vivo;Infiltration;Inflammation Mediators;Inflammatory;Injections;Intrathecal Injections;knock-down;Knock-out;Learning;Macrophage;Magnetic Resonance Imaging;Measures;Memory;Memory impairment;Microglia;monocyte;morris water maze;mouse model;Mus;Neurodegenerative Disorders;neuroinflammation;neurovascular;neurovascular unit;neutrophil;non-invasive imaging;novel;object recognition;Onset of illness;Pericytes;Play;Process;Proteins;Resolution;response;Role;Superior temporal gyrus;Symptoms;Testing;therapeutic evaluation;Tissues;treatment strategy;Up-Regulation;Vascular Diseases

PROJECT_TITLE: The Role of Pericytes in Brain Hypoperfusion in Alzheimer's Disease Development


NIH_SPENDING_CATS: Cancer;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: THE NETWORK DATA EXCHANGE – A NETWORK COMMONS FOR BIOLOGISTS NARRATIVE The Network Data Exchange (NDEx) is an online commons where scientists find, share, and publicly distribute biological networks. It also provides ‘omics interpretation tools that leverage its corpus of networks. NDEx plays an essential role in providing investigators with up-to-date knowledge of the molecular networks and pathways that underlie cancer and other major diseases.

PI_NAMEs: PRATT, DEXTER  (contact)

PROJECT_TERMS: anti-cancer research;Atlas of Cancer Mortality in the United States;automated text message;base;big biomedical data;Biological;Biology;Biomedical Research;Cancer Biology;cancer genome;Cancer Research Project;Collaborations;Collection;Communities;Computer software;Data;Data Analyses;data exchange;data exchange system;Data Science;Data Set;Databases;Destinations;Development;Disease;Documentation;Ecosystem;Evolution;Family;Feedback;Funding;genome analysis;Grant;Heterogeneity;Image Analysis;Informatics;Internet;interoperability;Java;Journals;Knowledge;Library Science;Licensing;Link;Literature;Malignant Neoplasms;Maps;meetings;Methods;Molecular;Nature;next generation;novel;open source;outreach;Pathway Analysis;Pathway interactions;Performance;Play;Publications;Published Comment;Publishing;Pythons;Reader;recruit;repository;Research Personnel;Role;Scientist;Series;Services;success;System;Technology;Time;tool;tool development;Training;tumor;Update;Visualization;Visualization software;web site

PROJECT_TITLE: The Network Data Exchange - a Network Commons for Biologists


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Epilepsy;Intellectual and Developmental Disabilities (IDD);Nanotechnology;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Several neuropeptides are well known in animal studies to show great promise for controlling seizures and ameliorating behavioral abnormalities; however, they do not readily cross the blood brain barrier and are rapidly metabolized when given systemically, thus limiting clinical application. To overcome this challenge, we developed an approach based on the encapsulation of neuropeptides in nanoparticles. We will determine the ability of nanoparticle encapsulated oxytocin and neuropeptide Y to ameliorate seizures and behavioral deficits in mouse models of severe childhood epilepsy caused by mutations in two sodium channels. The mechanism by which oxytocin increases seizure resistance in the mouse models will also be established.

PI_NAMEs: ESCAYG, ANDREW P (contact);MURNANE, KEVIN SEAN

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Active Biological Transport;Acute;Address;Adverse effects;Anatomy;Animal Model;Animals;anti-epileptic agents;Antiinflammatory Effect;autism spectrum disorder;Behavioral;behavioral phenotyping;biomaterial compatibility;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Brain region;cell type;Cells;Childhood;childhood epilepsy;Cholinergic Receptors;Clinical;clinical application;clinically relevant;Cognitive;Data;Death Rate;Developmental Delay Disorders;Disease;dravet syndrome;drug candidate;Encapsulated;Encephalopathies;Epilepsy;Exhibits;experimental study;Febrile Convulsions;Formulation;Functional disorder;gain of function;gamma-Aminobutyric Acid;Goals;Hippocampus;improved;Intellectual functioning disability;Interneurons;Ion Channel;Knowledge;Life;Literature;loss of function;loss of function mutation;Mediating;Modeling;mouse model;mutant;Mutant Strains Mice;Mutation;nanoformulation;nanoparticle;nanoparticle delivery;Nervous System Disorder;neural circuit;neuronal excitability;Neurons;neuropeptide Y;Neuropeptides;neuroprotection;novel;Oxytocin;patch clamp;Patients;Penetrance;pharmacologic;Pharmacological Treatment;Phenotype;Predisposition;Property;protective effect;Proteins;Publishing;rabies virus glycoprotein G;receptor;Recurrence;Regulation;Reporting;Resistance;Role;SCN8A encephalopathy;SCN8A gene;Seizures;side effect;social;Social Behavior;social deficits;Sodium Channel;Suggestion;Synapses;Technology;Testing;Therapeutic;transcytosis;Variant;voltage

PROJECT_TITLE: Exploring the role of oxytocin in the regulation of neuronal excitability

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Genetics;Human Genome;Microbiome;Pain Research;Rehabilitation;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Psychoneurological symptoms are the most common co-occurring symptoms causing distress among breast cancer survivors and can significantly compromise quality of life. Better understandings of the effect and mechanism by which effective interventions such as acupuncture mitigate psychoneurological symptoms is urgently needed. This knowledge will advance precision symptom care and improve quality of life for breast cancer survivors.

PI_NAMEs: LI, HONGJIN  (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: acceptability and feasibility;Acupuncture Therapy;Affect;Arthralgia;associated symptom;Biological Markers;biomarker signature;Breast Cancer survivor;Cancer Survivor;cancer therapy;Caring;clinical application;clinical practice;cost;Disease;Distress;effective intervention;Enrollment;Fatigue;fatty acid biosynthesis;fecal metabolome;fecal microbiome;functional status;Future;Glutamate Metabolism Pathway;Goals;gut microbiome;gut microbiota;Health;High Pressure Liquid Chromatography;Homeostasis;Hot flushes;Hypertension;immune function;improved;Individual;Inflammation;innovation;Integrative Therapy;Intervention;Knowledge;Kynurenic Acid;Kynurenine;liquid chromatography mass spectrometry;Malignant Neoplasms;Mental Depression;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;metabolome;metabolomics;microbiome;microbiome research;microbiota;multiple omics;National Cancer Institute;novel;novel marker;Outcome;Pain;pain score;Pathway interactions;Personal Satisfaction;personalized intervention;phase II trial;Phenotype;Play;Polypharmacy;Population;primary outcome;Protocols documentation;Quality of life;Quinolinic Acid;Randomized, Controlled Trials;reduce symptoms;Regulation;Reporting;response;Ribosomal RNA;Risk;Role;Science;secondary outcome;Serotonin;Serum;Severities;Sleep disturbances;symptom cluster;symptom management;Symptoms;systematic review;Time;Tryptophan;Tryptophan Metabolism Pathway;Validation

PROJECT_TITLE: A Multi-Omics Study of the Effect and Mechanisms of Acupuncture on Psychoneurological Symptoms Among Breast Cancer Survivors


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Social Determinants of Health

ORG_CITY: RALEIGH

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: NARRATIVE Completion of this proposal will establish an experimental system capable of efficiently testing for gene- environment interactions (GxE) that cause differential susceptibility to chemical exposure. By linking experimental and informatics expertise, we will leverage data to make more informed choices in choosing to study chemicals that show strong empirical support for GxE, rather than interrogate the same set of usual suspects. This addresses a critical public health need in the face of a growing chemical exposome, where certain chemicals may elicit severely adverse health effects that differ across populations.

PI_NAMEs: WRIGHT, FRED A. (contact)

PROGRAM_OFFICER_NAME: DUNCAN, CHRISTOPHER GENTRY

PROJECT_TERMS: Address;Affect;Behavior;Behavioral;behavioral phenotyping;Bioinformatics;Biological;Biological Assay;Birth;Candidate Disease Gene;Chemical Exposure;Chemicals;cognitive development;Data;Defect;Development;Developmental Process;Dimensions;Disease susceptibility;Embryo;Environment;environmental chemical;environmental chemical exposure;Environmental Exposure;Environmental Health;Equation;experimental study;Exposure to;Fertility;Fertilization;gene environment interaction;Genetic;Genetic Predisposition to Disease;Genetic Variation;Genome;Genomic Segment;Health;Health Hazards;Heritability;high throughput screening;Human;Impaired cognition;in vitro Assay;Incidence;Individual;individual response;Informatics;inter-individual variation;Link;Malignant Neoplasms;manufacture;Measures;Methods;model organism;Morphology;Neurodegenerative Disorders;novel;novel strategies;Outcome;Paint;Pattern;Phenotype;Play;Population;Population Heterogeneity;Predisposition;Process;Public Health;Reproducibility;Research;response;Risk;Role;screening;Signal Transduction;Solid;Speed;stem;System;Technology;Testing;Time;Variant;Vulnerable Populations;Zebrafish

PROJECT_TITLE: Characterizing Gene-Environment Interactions that Affect Individual Susceptibility to an Expanding Chemical Exposome

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Transplantation;Wound Healing and Care

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Dynamic OCE with acoustic micro-tapping for in vivo monitoring of skin graft surgeries Narrative Skin grafting is one of the key procedures in reconstructive and plastic surgeries but, at present, there are no non-contact techniques to quantitatively characterize grafted site healing and, especially, scar formation. The goal of this project is to develop a non-contact, non-invasive clinical tool to characterize, image and monitor graft procedures using volumetric, sub-mm resolved maps of skin elasticity. We propose Optical Coherence Elastography (OCE) to quantitatively monitor skin grafting by volumetric measurements of skin's Young's modulus and anisotropy in donor and recipient sites at a pre-operative stage, and during post-surgery graft healing at all steps (inflammation, proliferation and remodeling); we will use acoustic micro-tapping (recently developed by our group) to efficiently launch sub-mm elastic waves in skin, image propagating mechanical waves with state-of-the-art fast phase-sensitive OCT, and reconstruct skin's elastic properties from acquired data using a biomechanical model considering skin's finite thickness and anisotropic layered structure.

PI_NAMEs: PELIVANOV, IVAN  (contact)

PROJECT_TERMS: 3-Dimensional;4D Imaging;Acceleration;Acoustics;Age;Air;Algorithms;Angiography;Anisotropy;Area;Back;Benchmarking;Binding;biomechanical model;Biomechanics;Body mass index;Breast;Cicatrix;Clinic;Clinical;clinical application;clinical efficacy;Clinical Protocols;clinical translation;Collagen;Cornea;Cosmetics;Coupled;Data;Dermatology;Donor person;Elasticity;elastography;Ensure;Environment;Esthetics;experimental study;Face;Feedback;foot;Forearm;Future;Gender;Goals;graft healing;healing;healthy volunteer;Human;human subject;Image;Imaging Device;improved;in vivo;in vivo imaging system;in vivo monitoring;Inflammation;innovation;instrument;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mechanics;Medical;Methods;Modeling;Modulus;Monitor;Neck;Operative Surgical Procedures;Optics;Organ Transplantation;Outcome;Patients;Persons;Phase;Plastic Surgical Procedures;Population;Postoperative Procedures;Procedures;Process;Proliferating;Property;Protocols documentation;Radiation;Radiology Specialty;reconstruction;Reconstructive Surgical Procedures;Recovery;Resolution;Robot;Robotics;Sampling;Site;Skin;Skin graft;structural imaging;Structure;Subcutaneous Tissue;Surgical Oncology;System;Techniques;Testing;Therapeutic;Thick;Time;Tissue Donors;Tissue Grafts;Tissues;tool;Transplantation;ultrasound

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]