ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse;Tobacco

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative This proposal will develop novel chemical probes to target the nicotinic acetylcholine receptor (nAChR). The α4β2 nAChR presents in two distinct isoforms: the high sensitivity α42β23 nAChR, and the low sensitivity α43β22 nAChR. Our recently published findings have led to the hypothesis that drugs selectively targeting the high sensitivity α42β23 nAChR may provide a novel, previously undefined understanding of nicotine’s actions, and thus, the chemical probes derived from these studies may thereby lead to the development of more efficacious therapeutics to treat nicotine dependence in humans.

PI_NAMEs: FOWLER, CHRISTIE D;HAMOUDA, AYMAN K.;THAKUR, GANESH A (contact)

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: Acetylcholine;ADME Study;Adult;Affective;Affinity;Ames Assay;Amino Acids;analog;antinociception;aqueous;Attenuated;Behavior;Behavioral;behavioral outcome;Binding;Binding Sites;Biological Assay;Brain;Cardiac;Cells;Cessation of life;Characteristics;Chemicals;Chemosensitization;Computer Analysis;craving;CYP2C9 gene;CYP3A4 gene;Data;design;Development;Disease;drug development;Drug Kinetics;Eating;Electrodes;Electronic cigarette;electronic cigarette use;Ethers;Exhibits;Female;Future;Generations;Genes;Human;improved;In Vitro;in vivo;Incubated;Individual;Intake;Intravenous;Lead;lead optimization;Ligands;Literature;Liver Microsomes;male;Mediating;Membrane;Mental Depression;Metabolic;meter;Mus;Muscle;Mutation Analysis;natural hypothermia;Neurons;never smoker;Nicotine;Nicotine Dependence;nicotine exposure;nicotine self-administration;Nicotine Withdrawal;Nicotinic Receptors;novel;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacologic Actions;positive allosteric modulator;programs;Property;Protein Isoforms;Publishing;radioligand;Rattus;Receptor Signaling;Relapse;Rewards;Rodent;Role;Series;small molecule;smoking cessation;Solubility;Structure;Testing;Therapeutic;Tobacco Dependence;tool;Toxicity Tests;voltage clamp;Withdrawal;Xenopus oocyte

PROJECT_TITLE: Selective Positive Allosteric Modulators of a4b2 Nicotinic Receptors

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE This research project aims to investigate the causes and consequences of adenosine-mediated immunosuppression in pancreatic cancer (PDAC) and explore the efficacy of adenosine-targeted therapies. By understanding the mechanisms underlying adenosine signaling in the PDAC tumor microenvironment, the study will contribute to the fundamental knowledge about the complex interactions between cancer and immune cells in solid tumors. The potential development of adenosine-targeted therapies could have a positive impact on improving treatment options and outcomes for patients with pancreatic cancer, ultimately enhancing health and reducing illness and disability associated with this challenging disease.

PI_NAMEs: DONAHUE, TIMOTHY R (contact);RADU, CAIUS GABRIEL;WAINBERG, ZEV A

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Adenosine;Aftercare;Antibodies;ATP Hydrolysis;Bioinformatics;Biological Sciences;Biology;biomarker identification;Biometry;Blood;cancer type;cell type;Cells;checkpoint inhibition;chemotherapy;Clinical Data;Clinical Trials;Collaborations;Complex;Conduct Clinical Trials;Data;Dedications;Development;disability;Disease;DNA Damage;ecto-nucleotidase;efficacy testing;Enzymes;Epithelium;Evaluation;experimental study;extracellular;follow-up;Genetic Engineering;Health;Human;human model;human tissue;humanized mouse;Immune;immune resistance;Immuno-Chemotherapy;Immunologics;Immunosuppression;Implant;improved;Inflammation;inhibitor;innovative technologies;Intercellular Fluid;Investigation;Knowledge;Leukocytes;Ligands;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metabolism;Modeling;Monoclonal Antibodies;mouse model;Mus;Myeloid Cells;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel;nucleotide metabolism;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patient-Focused Outcomes;Patients;permissiveness;pharmacologic;Phase;Phase I/II Clinical Trial;Phase I/II Trial;Phase Ia/Ib Clinical Trial;Phenotype;predicting response;prevent;Production;programmed cell death protein 1;Research Project Grants;Resectable;Resistance;response;Role;sample collection;Sampling;Serum;Signal Transduction;Slice;small molecule inhibitor;Solid Neoplasm;Specimen;standard of care;synergism;targeted treatment;Techniques;Testing;Tissues;Treatment outcome;tumor;Tumor Biology;Tumor Immunity;tumor immunology;tumor microenvironment;tumor-immune system interactions;Work

PROJECT_TITLE: Causes and Consequences of Adenosine Signaling in Pancreatic Cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Precision Medicine;Sarcoidosis

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Sarcoidosis is a systemic condition, most commonly found in the lungs and thoracic lymph nodes, which has significantly worse disease prognosis when there is involvement of the heart. While there is evidence that immune-suppressant therapy can improve the outcome for patients, quantitative imaging-based criteria for the initiation and management of treatment of cardiac sarcoidosis are not well developed. This study will prospectively collect a comprehensive array of both standard cardiac MR, 18F-FDG PET, and 82Rb nuclear PET perfusion imaging data in patients undergoing a standardized treatment protocol, and develop novel imaging analyses, to determine the best predictors of cardiac function outcomes and longer-term adverse clinical outcomes, and the quantitative imaging-based measures of response to therapy that can be used to guide optimal treatment.

PI_NAMEs: FAYAD, ZAHI A. (contact);MORGENTHAU, ADAM S

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Adverse event;Affect;Agreement;American;Artificial Intelligence;artificial intelligence model;Biopsy;Cardiac;Cardiac Sarcoidosis;Cardiac Volume;cardiometabolism;Categories;Clinical;clinical care;Clinical Data;Cross-Sectional Studies;Data;Development;Diagnosis;disease prognosis;Dose;Enrollment;Evaluation;Event;extracellular;fibrogenesis;Fibrosis;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Future;Gadolinium;Goals;Granuloma;Granulomatous;Heart;Heart Arrest;Heart Block;Heart failure;heart function;Heterogeneity;Image;imaging biomarker;imaging study;Immune;improved;improved outcome;Individual;Infiltration;Inflammation;innovation;Knowledge;Left Ventricular Ejection Fraction;Logistic Models;Lung;Magnetic Resonance Imaging;Maps;Measurement;Measures;Modeling;Monitor;Morbidity - disease rate;mortality;Myocardial;Myocardial dysfunction;Myocardial perfusion;Myocardium;non-caseating granulomas;novel;Nuclear;Odds Ratio;optimal treatments;Outcome;outcome prediction;Pathologic;Patient-Focused Outcomes;Patients;Perfusion;perfusion imaging;Pharmaceutical Preparations;Positron-Emission Tomography;Prediction of Response to Therapy;Prednisone;Prognosis;prognostic value;prospective;Prospective Studies;Protocols documentation;quantitative imaging;radiomics;Regimen;response;Risk;ROC Curve;Sarcoidosis;Secondary to;serial imaging;Signal Transduction;Spatial Distribution;standard of care;Standardization;Steroids;Subgroup;Surrogate Markers;TEP1 gene;Testing;Therapeutic;Thoracic Lymph Node;Time;tissue mapping;Tissues;treatment guidelines;Treatment Protocols;treatment response;uptake;vasoconstriction;Ventricular Arrhythmia;Ventricular Tachycardia

PROJECT_TITLE: Advanced multi-parametric 18F-FDG PET and MRI imaging parameters of response to immune suppressant therapy in patients with active cardiac sarcoidosis

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: ALBUQUERQUE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Malaria is a major cause of illness and death worldwide, particularly among children under the age of five in areas with high transmission rates. By gaining a better understanding of the genes and proteins involved in immune system development, we can use this knowledge to aid in the discovery of new therapies to improve clinical outcomes. Our investigation will examine unvaccinated and vaccinated children who have received the first approved malaria vaccine to uncover molecular patterns linked to protection, breakthrough infections, and the severity of the disease.

PI_NAMEs: ANYONA, SAMUEL BONUKE;PERKINS, DOUGLAS JAY (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: acquired immunity;Acute Disease;Address;Affect;Africa South of the Sahara;African;Age;aptamer;Area;Bioinformatics;Birth;Blood specimen;breakthrough infection;Catalogs;Categories;Cessation of life;Child;Childhood;Clinical;clinical phenotype;Clinical Research;Clinical Trials;cohort;Cohort Studies;Collaborations;Computer Analysis;Computing Methodologies;Development;Disease;Disease Progression;Enrollment;experience;Favorable Clinical Outcome;follow-up;Fostering;Funding;Future;Gene Expression;Genes;Goals;Hemoglobin;high dimensionality;Human;Immune Response Genes;Immune system;Immunity;improved;Infection;Inflammatory;Infrastructure;innovation;insight;International;Intervention;Investigation;Kenya;Knowledge;Life;Link;Machine Learning;Malaria;Malaria Vaccines;malarial anemia;Measures;Mediating;Methods;Modeling;Molecular;molecular marker;Molecular Profiling;Molecular Target;Monitor;Morbidity - disease rate;mortality;mRNA sequencing;multidimensional data;multidisciplinary;Multiomic Data;multiple omics;National Institute of Allergy and Infectious Disease;novel;novel therapeutics;Outcome;Participant;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Pattern;Phase;Plasma;Plasmodium falciparum;Prognosis;prospective;Proteins;Proteome;Proteomics;Public Health;Recovery;recruit;Research Personnel;Risk Assessment;Severities;Severity of illness;Statistical Data Interpretation;Statistical Methods;Systems Development;Technology;Therapeutic;Therapeutic Intervention;therapeutic target;Training;transcriptome;transmission process;United States National Institutes of Health;unvaccinated;Vaccinated;Vaccination;Vaccines;Visit;Whole Blood

PROJECT_TITLE: Harnessing the Malarial Immunity Omics Landscape in Vaccinated and Unvaccinated Children for Improved Therapeutic Strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-E (02)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Microbiome

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

ORG_STATE: MA

PHR: Projective Narrative There are many ultra-small bacteria in our body, including in the mouth, that cannot live by themselves, but rather require intimate physical association with other bacteria to grow, which makes it difficult to study them in the laboratory. Our research is focused on studying, at the molecular level, the first ultra-small bacterium that has been successfully isolated from the oral cavity and grown in our laboratory. Once we understand how it interacts with its partner and affects other oral bacteria, it will help to investigate their role in our health and disease.

PI_NAMEs: HE, XUESONG  (contact);MCLEAN, JEFFREY SCOTT

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TITLE: Domestication and characterization of TM7-the most elusive oral phylum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (03)]


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative This application requests support to build upon a novel 1-year dissemination and implementation conference grant in which the University of Chicago Comprehensive Care Program (CCP) research team will engage 65-75 health care leaders and clinicians and social service providers through an in-person 1.5-day conference in Chicago and monthly virtual sessions for the duration of the project period. The conference will focus on applying an implementation science approach to the development, implementation, and evaluation of evidence-based care delivery models that create relational continuity across inpatient and outpatient settings for patients at increased risk of hospitalization and explicitly address both complex medical and social needs. This will be the second conference to focus on the topic of comprehensive care models, or models that defragment care for patients at increased risk of hospitalization, and through a 1.5-day conference, monthly virtual convening opportunities, and conference deliverables, including a webpage with CCP dissemination tools and learnings, will reach a diverse set of health care stakeholders and patient populations that they serve.

PI_NAMEs: MELTZER, DAVID O (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Applying an Implementation Science Lens to Defragmenting Care for Patients at Increased Risk of Hospitalization: A Conference on Comprehensive Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZHS1 HSR-T (01)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Chronic heavy alcohol use and Alzheimer’s disease (AD) alter brain metabolic function, neuronal activity and promote neurodegeneration. Heavy alcohol increases AD risk, and rodent studies implicate microglia in neuronal dysfunction. Using cutting edge 3D human reciprocal neurocircuits, we propose to determine if a microglia dysregulation of neuronal metabolism increases neuronal activity and degeneration to promote pathology alcohol- and AD pathology in human brain.

PI_NAMEs: COLEMAN, LEON GARLAND (contact);MACDONALD, JEFFREY M.

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: 3-Dimensional;abeta accumulation;Acetates;Acetyl Coenzyme A;Acetyl-CoA Carboxylase;alcohol use disorder;Alcohol-Induced Neurotoxicity;Alcohols;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Astrocytes;axon growth;axonal degeneration;beta amyloid pathology;Brain;Brain Diseases;Brain Injuries;Brain region;Cell Culture Techniques;Chronic;Disease;Esters;Ethanol;Ethanol Metabolism;Fatty Acids;Functional disorder;Future;glial activation;Glucose;glucose metabolism;Glycolysis;Heavy Drinking;Human;human induced pluripotent stem cells;Hyperactivity;Immunofluorescence Immunologic;Impairment;In Situ Nick-End Labeling;in vivo;Induced pluripotent stem cell derived human neuron;Inflammatory;inhibitor;intraneuronal beta amyloid;Link;lipid metabolism;lipidomics;Lipids;Lipoidosis;Lysosomes;LysoTracker;Mass Fragmentography;Metabolic;Metabolic dysfunction;Microelectrodes;Microfluidics;Microglia;Modeling;mutant;Nerve Degeneration;network dysfunction;neuron loss;Neuronal Dysfunction;neuronal metabolism;Neurons;novel;Pathology;Pathway interactions;presenilin-1;prevent;Regulation;Reporting;Risk Factors;Rodent;Role;Signal Transduction;Synapses;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Work

PROJECT_TITLE: 3D Human neurocircuits to determine the role of microglia in AUD and Alzheimer's neuronal pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-M (03)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The goal of this Focused Technology Research and Development R01 project is to further develop solid-state nanopore technology and build on its current utility for hyaluronan molecular weight analysis to become a more general glycan screening tool. First, we will expand hyaluronan analysis to include direct quantification and then integrate the processes with a microfluidic device for easy dissemination. We will then extend the approach beyond hyaluronan alone to include both isoform-specific evaluation of heavy chain modified hyaluronan and two key sulfated glycans, heparan sulfate and chondroitin sulfate.

PI_NAMEs: HALL, ADAM ROGER (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TITLE: Development of solid-state nanopore technology for improved glycosaminoglycan analytics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (80)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PUBLIC HEALTH RELEVANCE Glucose transporter 1 deficiency syndrome (G1D) is most often associated with lifelong medication-refractory neurological dysfunction. At present, G1D can only be alleviated by interventions such as the ketogenic diet, which can be poorly tolerated and afford only an incomplete restoration of neural function. A better understanding of G1D via the organized interaction of public advocates, scientists and clinicians in a summit fulfills the NIH mission by expanding current perspectives on new fundamental aspects of brain function and on the development of new therapies guided by a strong patient focus.

PI_NAMEs: PASCUAL, JUAN M. (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Adopted;Advocacy;Advocate;Agreement;Animal Model;Basic Science;Biological Markers;Birth;Brain;Caregivers;Cells;Clinic;clinical care;Clinical Data;Clinical Trials;Clinical Trials Design;Collaborations;Communities;Consensus;Country;data sharing;Dementia;Development;Diagnostic;dietary;Disease;disease phenotype;effective therapy;Effectiveness;Epilepsy;Epileptogenesis;Event;Evolution;Exhibits;Facebook;Family;Family member;Fertilization;Fostering;Foundations;Functional disorder;Funding;Future;Generalized Epilepsy;Genes;Glucose Transporter;Goals;Grant;Guidelines;Home;Information Dissemination;Intellectual functioning disability;Intellectual impairment;International;Intervention;ketogenic diet;Laboratories;life span;Location;Malignant Neoplasms;man;Medical;meetings;Metabolism;Methodology;Mission;Molecular;motor control;motor disorder;Multilingualism;Mus;Mutation;neural circuit;Neurologic Dysfunctions;neurophysiology;Neurophysiology - biologic function;Newsletter;novel;novel therapeutics;Pathogenicity;Patient Care;patient oriented;Patients;Persons;Pharmaceutical Preparations;Physicians;Positioning Attribute;Prevalence;Principal Investigator;public health relevance;Recommendation;recruit;Refractory;Research;Research Personnel;Research Priority;Resources;restoration;Safety;Science;Scientist;Sister;SLC2A1 gene;symposium;synaptic function;Syndrome;Telephone;Therapeutic;therapeutic development;Time;tool;Translational Research;Underrepresented Populations;United States National Institutes of Health;Update;virtual;Voice;web site;Woman;Work

PROJECT_TITLE: The 11th international Glut1 deficiency summit

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (45)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Prevention;Substance Misuse

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Alcohol use disorder and overweight/obesity are highly prevalent and costly disorders that affect an increasing proportion of U.S. adults. Recent evidence suggests that incretin-based treatments for diabetes and overweight/obesity show potential as treatments for alcohol use and other addictive behaviors. This clinical trial will evaluate whether tirzepatide, the first in a new class of therapies for diabetes and overweight/obesity, shows potential for reducing alcohol use and cardiovascular risk factors in adults with co-occurring alcohol use disorder and overweight/obesity.

PI_NAMEs: HENDERSHOT, CHRISTIAN S (contact)

PROGRAM_OFFICER_NAME: SENEVIRATNE, CHAMINDI

PROJECT_TERMS: addiction;Addictive Behavior;Adherence;Adoption;Adult;Adverse event;Affect;Agonist;alcohol abuse therapy;Alcohol consumption;alcohol reward;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;analog;attributable mortality;Blood Pressure;Body Weight;Body Weight decreased;burden of illness;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cholesterol;Chronic;Clinic Visits;Clinical;Clinical Research;Clinical Trials;cost;Development;Diabetes Mellitus;diabetes mellitus therapy;Disease;Dose;Double-Blind Method;drug repurposing;early alcohol use;effective therapy;Epidemiological trend;Epidemiology;expectation;Face;Frequencies;gastric inhibitory polypeptide receptor;GLP-I receptor;glucagon-like peptide 1;glycemic control;Glycosylated hemoglobin A;Head;Health;Heavy Drinking;High Prevalence;hindbrain;incretin hormone;indexing;Ingestion;Liver diseases;Malignant Neoplasms;Measures;Metabolic;Mus;Neuropeptides;next generation;nonhuman primate;novel therapeutics;Nutrient;Obesity;obesity treatment;Outcome;Outpatients;Overweight;Participant;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;phase 2 testing;phase II trial;phase III trial;Placebos;Positioning Attribute;pre-clinical;Prevalence;primary outcome;prospective;protective effect;Public Health;randomized trial;Rattus;receptor;recruit;reduced alcohol use;Reporting;Research;response;Risk;Sampling;secondary outcome;side effect;Time;trend;Triglycerides;United States;United States Food and Drug Administration;uptake;Visit;Weight;Work

PROJECT_TITLE: Phase II Evaluation of Tirzepatide in Adults with Alcohol Use Disorder and Overweight or Obesity

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Biomanufactured tissues hold significant promise for the future of organ transplantation and drug discovery. However, engineering algorithms are needed to design three-dimensional multicellular tissues that will evolve with specific structural configurations or patterns as cells signal one another to undergo phenotypic changes. This project will fill that void by establishing and validating the first multiscale computational model for predicting and designing multicellular tissues comprised of cells whose behaviors are regulated by engineered signaling circuits controlling cell-cell adhesion.

PI_NAMEs: LAZZARA, MATTHEW J (contact);PEIRCE-COTTLER, SHAYN

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: 3-Dimensional;3D Print;Adhesions;Adhesives;Algorithm Design;Algorithms;Behavior;Biochemical;Biocompatible Materials;Biomanufacturing;Biomechanics;bioprinting;Cell Adhesion;cell behavior;Cell Communication;cell type;Cell-Cell Adhesion;Cells;Cellular Structures;Characteristics;Collection;Complex;Computer Models;Confocal Microscopy;Coupled;Data Set;design;Dimensions;drug discovery;Drug Implants;Drug Screening;Engineering;engineering design;Environment;Equilibrium;Exhibits;experimental study;extracellular;Eye;fabrication;Fibroblasts;Foundations;Future;Generations;Genes;Genetic Engineering;Goals;high reward;high risk;Homo;Image;Image Analysis;Individual;Institution;large scale production;Machine Learning;machine learning algorithm;Mediating;microscopic imaging;Modeling;multi-scale modeling;Mus;notch protein;novel;optogenetics;Organ;Organ Transplantation;P-Cadherin;Pattern;Pattern Formation;Phenotype;Population;Population Heterogeneity;Positioning Attribute;predictive modeling;predictive tools;Property;Publishing;quantitative imaging;regenerative;Reproducibility;Running;scaffold;self assembly;self organization;Shapes;Signal Transduction;simulation;Soccer;Sorting;Specific qualifier value;spheroids;Structure;success;Synthetic Genes;System;Technology;Time;Tissue constructs;Tissue Engineering;Tissues;tool;Training;unsupervised clustering;Validation;Work

PROJECT_TITLE: Multiscale Computational Modeling to Design Patterned Tissue Assembloids for Biomanufacturing

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The 2024 National LGBTQ Health Conference will bring together leading researchers, practitioners, trainees and students to address health inequalities and disparities in the LGBTQ population to improve the lives of all LGBTQ people through an intersectional lens while providing substantial professional and networking support for junior underrepresented colleagues.

PI_NAMEs: GUEST, JODIE  (contact)

PROGRAM_OFFICER_NAME: MEZA-CERVERA, TATIANA

PROJECT_TERMS: Address;Affect;Age;Attention;Award;barrier to care;cardiovascular risk factor;career;Chicago;Civil Rights;Collaborations;Communities;community engagement;Community Health;Development;Disabled Persons;Discrimination;Disease;Disparity;Education;Educational process of instructing;Eligibility Determination;ethnic minority;evidence base;experience;Faculty;Foundations;Funding;Future;gender minority health;gender minority health research;Geography;Goals;Health;Health Disparities Research;health disparity;health disparity populations;health inequalities;Health Professional;Health Services Accessibility;Healthcare;HIV;Human Rights;improved;Incidence;Individual;Inequity;innovation;Institute of Medicine (U.S.);Institution;Knowledge;Leadership;Legal;lens;Lesbian Gay Bisexual Transgender;Lesbian Gay Bisexual Transgender Queer;LGBT Health;Life Expectancy;Link;Location;Low Income Population;Medical;Mental Health;Mentorship;Minority;minority communities;Minority Status;next generation;NIH Program Announcements;Oral;Outcome;Participant;people of color;Personal Satisfaction;Persons;physical conditioning;Policies;Population;Postdoctoral Fellow;posters;Prevalence;prevention service;programs;Provider;Public Health;Quality of Care;Quality of life;racial minority;recruit;Request for Proposals;Research;Research Personnel;Risk;same-sex marriage;Scholarship;Science;Scientist;Service provision;Sexual and Gender Minorities;Social Discrimination;social stigma;Strategic Planning;Students;Substance abuse problem;Suicide;support network;symposium;Time;Training;training opportunity;transgender;Translational Research;Transportation;Travel;Underrepresented Populations;United States National Institutes of Health;Universities;Woman;Work;Youth

PROJECT_TITLE: National LGBT Health Conference 2024

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (C1)]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The purpose of this R13 conference grant is to seek partial funding for the second international Computational Psychiatry Conference. This meeting will bring together a diverse array of junior and senior investigators working on both clinical and computational questions related to mental health, including addiction. A successful second meeting will help ensure that this conference becomes a productive and career-enhancing annual event for researchers in this new field to translate neuroscience discoveries into psychiatric clinical practice and to use clinical observations to generate new discoveries in neuroscience.

PI_NAMEs: REDISH, A DAVID (contact)

PROJECT_TERMS: addiction;Address;Area;Award;Black race;brain research;career;Career Choice;career development;Clinical;clinical practice;Clinical Sciences;college;Communities;community engagement;Community Psychiatry;computational neuroscience;Development;early experience;Educational workshop;Ensure;equity, diversity, and inclusion;Event;Faculty;Funding;Generations;Goals;Grant;health disparity;Individual;International;Ireland;knowledge base;Learning;Location;London;marginalized community;medical schools;Medicine;meetings;member;Mental Health;Minnesota;Modeling;multidisciplinary;Neurosciences;Participant;Persons;Play;posters;Productivity;professor;Psychiatry;Psychological reinforcement;Randomized;Research;Research Design;Research Personnel;Resources;Rest;Role;Running;Scholars Program;Science;Scientist;social media;Societies;success;symposium;Training;Translating;Travel;Underrepresented Populations;Universities

PROJECT_TITLE: Computational Psychiatry 2024 Conference


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Damage to the primary visual cortex causes a debilitating loss of conscious vision, from which recovery is often described as “impossible”. Although training with motion-based visual stimuli can restore some discrimination abilities, these are limited, and appear to differ from blindsight. Here we will develop an animal model of primary visual cortex damage to elucidate the neurons, pathways and processing changes implicated in training-induced vision recovery, improving our ability to devise more effective, principled and comprehensive vision therapies.

PI_NAMEs: HUXLIN, KRYSTEL R;NIELSEN, KRISTINA J. (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Anatomy;Anesthesia procedures;Animal Model;Animals;Area;area striata;Automobile Driving;Autopsy;Biological Assay;blind;Blindness;Bypass;cell type;Cells;cohort;Complex;Conscious;Contralateral;Coupling;Custom;design;Discrimination;discrimination task;Dorsal;extrastriate visual cortex;Feedback;Ferrets;Foundations;Future;Goals;Histology;Homologous Gene;Human;Ibotenic Acid;Impairment;improved;information processing;Joints;koniocellular;Lateral;Lateral Geniculate Body;Lesion;Link;magnocellular;Measurement;Measures;Medial;Mediating;Modeling;Modification;Motion;Motion Perception;multi-electrode arrays;neurochemistry;neuronal circuitry;Neurons;neurophysiology;novel;Outcome;parallel processing;parvocellular;Pathway interactions;Patients;Physiological;Physiological Adaptation;Physiology;Population;Primates;Process;Property;Reading;Recovery;Residual state;response;Rodent;sight restoration;Site;Stimulus;Stream;Stroke;Testing;Thalamic structure;Training;treatment strategy;Unconscious State;V1 neuron;Vision;Visual;visual discrimination;Visual Fields;visual information;visual processing;visual stimulus;Visual System;Work

PROJECT_TITLE: Neuronal mechanisms underlying training-induced vision recovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Prevention

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE High blood pressure and excess food intake enhance the risk for impaired filling of the heart, as the heart becomes thicker and stiffer due to enlargement of heart cells and the production of stiffening fibers. In about half the patients hospitalized for heart failure, their heart can still contract properly, but it fails to relax and refill with blood. Here, we test the hypothesis that toxic lipids termed ceramides relay signals that enlarge and stiffen the cells of the heart and test novel drugs that can improve heart function by lowering these lipids.

PI_NAMEs: HOLLAND, WILLIAM L (contact);SUMMERS, SCOTT A

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Ablation;Anabolism;anaerobic glycolysis;antagonist;Automobile Driving;biobank;Biological Markers;Biopsy;Blood;Carbon;Cardiac;Cardiac Myocytes;Cardiomegaly;cardiovascular disorder risk;Cardiovascular system;Cell Physiology;Cells;Ceramides;Citric Acid Cycle;Clinic;Clinical Trials;comparison control;Complex;Contracts;coronary fibrosis;Data;Deposition;desaturase;detection of nutrient;Development;diabetic;Diastolic heart failure;dihydroceramide desaturase;Disease;drug candidate;drug discovery;Eating;efficacy evaluation;EFRAC;Electron Transport;Enzymes;Etiology;Event;evidence base;Excision;Exhibits;experience;Failure;Fiber;Fibrosis;Functional disorder;galactosylgalactosylglucosylceramidase;Gene Modified;Genetic;Genetic Induction;Genetic Transcription;Glucose;glucose metabolism;Glucose Transporter;Heart;heart cell;Heart failure;heart function;Heart Hypertrophy;heart metabolism;Heart Transplantation;Hospitalization;Human;human tissue;Hypertension;Hypertrophy;Impairment;improved;in vivo;inhibitor;innovation;Isocitrate Dehydrogenase;Kentucky;Knockout Mice;Lead;Link;lipidomics;Lipids;Measures;Mediator;Metabolism;Mitochondria;mitochondrial dysfunction;Morphology;mouse model;Mus;Myocardial;Myocardium;novel;novel therapeutics;oxidation;Pathology;Pathway interactions;Patient risk;Patients;pharmacokinetics and pharmacodynamics;pharmacologic;Plasma;Predisposition;preservation;prevent;Prevention;Production;programs;Property;Publishing;Rattus;Recovery;Relaxation;repository;Risk;Rodent;Rodent Model;Role;Safety;Sampling;Serum;Signal Transduction;Sodium;Sphingolipids;Structure;targeted treatment;Testing;theories;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Tissues;Traction;Transforming Growth Factor beta;Transgenic Organisms;Transplant Recipients;Treatment Efficacy;Universities;Utah;Work

PROJECT_TITLE: Ceramides in Diastolic Heart Failure

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Diabetic retinopathy is a leading cause of blindness and disproportionally affects Hispanics/Latinos. Although biomarkers and genetic variants have been independently associated with diabetic retinopathy, significant gaps remain in understanding their causal functional pathways. Focusing on an understudied Hispanic/Latino population disproportionately impacted by cardiometabolic disease (the Cameron County Hispanic Cohort) our study will clarify mechanistic causes/consequences of diabetic retinopathy-associated expression patterns in the blood in order to inform disease mechanisms and suggest potential novel biomarkers and drug targets for its management.

PI_NAMEs: BELOW, JENNIFER ;FISHER-HOCH, SUSAN P;NORTH, KARI E.;PADOVANI-CLAUDIO, DOLLY ANN (contact)

PROGRAM_OFFICER_NAME: SHOAIBI, AZADEH

PROJECT_TERMS: Address;Affect;Area;biobank;Biological Markers;Blindness;Blood;Blood specimen;burden of illness;candidate identification;Cardiometabolic Disease;cardiometabolism;Chronic Disease;Clinical;Clinical Data;clinical diagnosis;Clinical Trials;clinically significant;cohort;comorbidity;Complex;County;cytokine;Data;Data Analyses;data modalities;Data Science;Data Set;Databases;Development;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Diagnosis;Disease;Drug Targeting;Dyslipidemias;early detection biomarkers;Electronic Health Record;Endothelial Cells;Epidemiology;Etiology;Eye diseases;Fatty Acids;Functional disorder;functional genomics;Fundus;Gene Deletion;Gene Expression;gene function;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic Risk;Genetic Transcription;genetic variant;genome wide association study;Genomics;Goals;Health;High Prevalence;high risk;Hispanic;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Human;IL8RA gene;IL8RB gene;improved;Individual;Inflammatory;inhibitor;Institution;Interleukin-1 beta;Joints;Latino Population;Ligands;Link;Literature;Maps;Measures;Mendelian randomization;Meta-Analysis;Metabolic;Metabolic Diseases;metabolic profile;metabolomics;Methods;Mexico;Modeling;Molecular;Molecular Profiling;multiple chronic conditions;multiple omics;Mus;Neuroglia;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Not Hispanic or Latino;novel;novel diagnostics;novel marker;novel therapeutics;Obesity;ophthalmic examination;Optical Coherence Tomography;Outcome;Participant;Pathogenicity;Pathway Analysis;Pathway interactions;Patient Self-Report;Patients;Pattern;phenome;Phenotype;polygenic risk score;Population;potential biomarker;predictive modeling;Prevalence;prospective;protein expression;Proteins;Quantitative Trait Loci;Regulation;Research;research study;Resources;Retina;retinal angiogenesis;Retinal Diseases;retinal imaging;Retinal Neovascularization;Risk;Risk Factors;risk stratification;Role;Sampling;Signal Transduction;sociodemographics;Strategic Planning;Testing;TNF gene;Transcript;transcriptome sequencing;transcriptomics;Underrepresented Populations;Underserved Population;United States;United States National Institutes of Health;Variant;Vision;Vision research;vision science;Visual impairment;Whole Blood;Wild Type Mouse

PROJECT_TITLE: Integrative multi-omics for discovery of molecular pathways associated with diabetic retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

PHR: PROJECT NARRATIVE Dengue is a globally expanding mosquito borne viral disease resulting in clinical disease ranging from febrile illness to hemorrhagic fever, to dengue shock syndrome, that can be fatal. Understanding the pathogenesis of this infection and associated disease is the foundation premise upon which the development of vaccines and clinical interventions will be predicated. We will contribute to this understanding by addressing the delicate equilibrium between direct viral and immune factors operating during severe disease in human dengue natural infections.

PI_NAMEs: KAJA, MURALI KRISHNA  (contact);SUTHAR, MEHUL SHAMAL

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Address;Affinity;Anti-Inflammatory Agents;Antibodies;Antibody-Dependent Enhancement;Antigens;Area;Binding;Blood Platelets;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cellular Tropism;chemokine;Child;Clinical;Clinical Management;clinical sequencing;cohort;Consensus;Coupled;cytokine;Dengue;Dengue Infection;Dengue Shock Syndrome;differential expression;Disease;Disease Outcome;Endothelium;Equilibrium;Fever;fitness;Foundations;Frequencies;glycosylation;Hospitals;Human;human monoclonal antibodies;IgG1;immune activation;Immune response;Immunity;Immunoglobulin Somatic Hypermutation;Immunologic Factors;Immunology;in vivo;India;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Intervention;Joints;Knowledge;Laboratories;Light;Measures;Mediating;Molecular;monocyte;mosquito-borne;Myelogenous;novel;Outcome;Pathogenesis;Pathologic;Patients;Pattern;Phenotype;Plasmablast;Polysaccharides;Population;Post-Translational Protein Processing;Primary Infection;Protocols documentation;Public Health;Research;Resources;response;Risk Factors;Role;Sampling;secondary infection;Serotyping;severe dengue;sialylation;single-cell RNA sequencing;T cell response;T-Lymphocyte;Technology;Thrombocytopenia;tool;United States;vaccine development;Vaccines;Vascular Permeabilities;Viral;Viral Hemorrhagic Fevers;Viral Load result;Virus Diseases;virus genetics;whole genome

PROJECT_TITLE: Immune responses associated with severe disease in patients with primary dengue infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-L (02)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease

PHR: Ventricular tachycardia is generally treated with catheter ablation which at best has a modest success and some associated risks. We are proposing to use radiation as the energy for ablation making it non-invasive and a much shorter procedure that can be done as an outpatient.

PI_NAMEs: RANJAN, RAVI  (contact)

PROGRAM_OFFICER_NAME: SHANBHAG, SUJATA MADHUKAR

PROJECT_TERMS: Ablation;ablative procedure;Acute;Address;Affect;Anatomy;Animal Model;Animals;Area;Arrhythmia;biological effect of radiation;Biophysics;canine model;Cardiac;Cardiac ablation;Catheters;Chronic;Cicatrix;Clinical;Collaborations;comorbidity;Complication;Computer Models;Confocal Microscopy;cost;Databases;Diffuse;Dose;Edema;Electrocardiogram;Electron Microscopy;Electrophysiology (science);exhaust;Failure;Fibrosis;General Anesthesia;Goals;Heart;Heart failure;heart function;heart imaging;hemodynamics;Histology;Hour;Human;Image;improved;improved outcome;in silico;Infarction;Ionizing radiation;Life;Magnetic Resonance Imaging;Malignant neoplasm of thorax;Maps;Mechanics;Methods;Modality;Modeling;models and simulation;MRI Scans;Myocardial;Myocardium;Nature;Oncology;Outpatients;Patients;Periodicals;Physiological;pre-clinical;Pre-Clinical Model;pre-clinical research;Procedures;programs;protein expression;Radiation;Radiation Biophysics;Radiation Dose Unit;radiation effect;Radiation Oncologist;Radiation Oncology;Radiation therapy;radio frequency;Reporting;Resolution;response;Risk;Risk Reduction;Running;simulation;Site;success;targeted treatment;Therapeutic Uses;Time;timeline;Tissues;treatment duration;Uncertainty;Universities;Utah;Validation;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia

PROJECT_TITLE: Radiation Guided Ablation for Ventricular Tachycardia

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Cancer;HIV/AIDS;Hematology;Immunization;Lymphatic Research;Lymphoma;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE B cells produce protective antibodies upon infections or immunizations. The main goal of this research is to investigate the precise mechanism of vigorous proliferation that B cells undergo to produce high affinity antibodies. Completion of this work will provide fundamental mechanistic insight into adaptive immunity with important implications for B cell lymphoma and human health.

PI_NAMEs: VICTORA, GABRIEL D (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: activation-induced cytidine deaminase;adaptive immunity;Address;Affinity;Anatomy;Antibodies;Antibody Affinity;antigen binding;Antigens;Automobile Driving;B Cell Proliferation;B-Cell Antigen Receptor;B-Cell Development;B-Cell Lymphomas;B-Lymphocytes;Biochemistry;Biology;Cell Cycle;Cell division;Cell Proliferation;Cells;Clone Cells;cyclin D3;Darkness;Data;Development;Dose;Equilibrium;Event;Exposure to;Flow Cytometry;Future;G1 Phase;Generations;Goals;Grant;Health;Hour;Human;Image;imaging platform;Immune system;Immunization;Immunoglobulin Genes;Immunologics;Immunology;in vivo;Infection;insight;intravital imaging;Light;lymphoid structures;Lymphoma;Lymphomagenesis;Malignant - descriptor;Mammalian Cell;Memory;Microanatomy;Mitogens;Molecular;mouse genetics;multiphoton microscopy;Mutation;pathogen;Pathway interactions;Pattern;Phase;Plasma Cells;Play;Population;Process;programs;Proliferating;Property;Proteins;Reaction;Research;Research Proposals;Resolution;Role;S phase;segregation;sensor;Serum;Signal Transduction;spatiotemporal;Speed;Structure of germinal center of lymph node;T-Lymphocyte;Techniques;Testing;Time;tool;two photon microscopy;Visualization;Work

PROJECT_TITLE: Molecular control of germinal center selection and affinity maturation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-Y (02)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE For persons living with chronic kidney disease, the leading causes of morbidity and mortality are cardiovascular. We propose to use comprehensive molecular profiling methods to interrogate upstream inflammatory mediators of cardiorenal risk with the overarching goal of identifying potential targets for prevention and intervention.

PI_NAMEs: CHENG, SUSAN  (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Adult;adverse outcome;Anti-Inflammatory Agents;Beds;biological adaptation to stress;Blood Vessels;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cellular Stress;Chronic;Chronic Kidney Failure;Clinical;cohort;Communities;Coronary;Coronary Arteriosclerosis;Coupled;CRISPR screen;Data;Development;disease phenotype;Disease Progression;disorder control;Eicosanoids;Endothelial Cells;Event;Excretory function;experience;Experimental Models;Family;fatty acid metabolism;Feedback;Fibroblasts;Follow-Up Studies;Framingham Heart Study;Functional disorder;Genetic;Goals;GTP-Binding Proteins;heart cell;hemodynamics;Human;Impairment;in vivo;Incidence;Individual;Inflammation Mediators;Inflammatory;Inflammatory Response;Intervention;Kidney;kidney cell;Kidney Diseases;kidney dysfunction;kidney fibrosis;kidney vascular structure;Knowledge;Leukotrienes;Link;Lipids;Lipoxins;Lipoxygenase;Lipoxygenase Inhibitors;Mass Spectrum Analysis;Measures;Mediating;Mediator;Methods;Modeling;Molecular Profiling;Morbidity - disease rate;mortality;Multi-Ethnic Study of Atherosclerosis;Mus;Natriuresis;Nephrectomy;new therapeutic target;novel;novel therapeutic intervention;Nuclear Hormone Receptors;Outcome;Pathway interactions;Patients;Persons;Polyunsaturated Fatty Acids;pressure;Prevention;Prostaglandins;Renal function;response;response to injury;Risk;Risk Factors;Risk Reduction;RNA Interference;Role;Severity of illness;Signal Transduction;small molecule;Sodium Chloride;standard care;systemic inflammatory response;Testing;therapeutic target;Time;Tubular formation;Variant;Work

PROJECT_TITLE: Eicosanoids, Chronic Kidney Disease Progression, and Associated Cardiovascular Risk

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: Project Narrative The goal of the Broadening Biomedical Research Workforce Participation through Culturally Responsive Mentoring conference is to increase awareness and knowledge of asset-based and culturally responsive mentoring approaches to broaden participation in the biomedical workforce. We propose an opportunity to learn, network, and discuss research and practical approaches for conducting mentoring in an intentional and structural way, using asset-based and culturally responsive approaches, as a means to enhance participation in the biomedical workforce and train the next generation of scientists.

PI_NAMEs: JAVIER, DAMARIS  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: Administrator;Awareness;Behavioral Research;Biomedical Research;broadening participation research;career;Collaborations;Communities;Community Networks;Community of Practice;Development;Education;Ethnic Origin;Faculty;Funding;Goals;Group Practice;Health;Human Resources;improved;Individual;Institution;Institutionalization;Knowledge;Leadership;Learning;marginalized community;marginalized population;Measures;member;Mentors;Mentorship;Mind;minority communities;Minority-Serving Institution;next generation;online community;Organizational Change;Organizational Culture;Outcome;Participant;peer;Policy Maker;Pre-Post Tests;programs;Race;Recommendation;recruit;Report (document);Research;research to practice;Resources;Scholarship;science, technology, engineering, mathematics, and medicine;Scientist;Students;success;symposium;Texas;Training;United States National Institutes of Health;Universities;working group

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-V (IP)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The Molecular Genetics of Bacteria and Phages (MGBP) Meeting provides training, career development, and networking opportunities for both young and established scientists who seek to understand the molecular mechanisms underlying the basic physiology of bacteria and phages and how they interact with each other and their hosts. The focus of the MGBP Meeting is directly applicable to the scientific missions supported by the National Institutes of Health, including the diverse, equitable, and inclusive support of both basic and applied research to understand, prevent and treat infectious diseases.

PI_NAMEs: CHAMPION, PATRICIA A;SIMMONS, LYLE ;VAN KESSEL, JULIA C. (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TERMS: Advocate;Applied Research;Award;Bacteria;Bacteriophages;Basic Science;Career Choice;career development;Caring;Child Care;Collaborations;Communicable Diseases;Communities;community building;Country;COVID-19;diversity and inclusion;Doctor of Philosophy;Environment;Equity;Event;Faculty;Family;Female;Fostering;Funding;gender diversity;graduate student;Grant;human disease;human pathogen;innovation;Laboratories;marginalized population;meetings;member;Mentors;Microbial Biofilms;Microbiology;mid-career faculty;Mission;Molecular;Molecular Biology;Molecular Genetics;Oral;Physiology;Postdoctoral Fellow;posters;prevent;Private Sector;programs;Pseudomonas;racial diversity;Research;Research Personnel;Running;Science;Scientific Advances and Accomplishments;Scientist;Site;Students;symbiont;symposium;Techniques;Training;undergraduate student;United States;United States National Institutes of Health;Universities;US State;Virus;waiver;Wisconsin;Work

PROJECT_TITLE: Molecular Genetics of Bacteria and Phages Conference 2024

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-D (M1)]


NIH_SPENDING_CATS: Cancer

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

PHR: Narra�ve Protein phosphatases play key roles in regulating cellular function and they are altered in nearly all human diseases; however, they are understudied. This application requests limited financial support for the only North American Protein Phosphatase Conference, to bring scientists together to learn more about these important proteins. The funds will be used to support attendance of early career and underrepresented scientists.

PI_NAMEs: SEARS, ROSALIE C (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Academia;Acceleration;Achievement;Address;American;Attention;Australia;Basic Science;Biology;California;Cardiovascular system;career;Career Choice;career development;Cell Physiology;Chemicals;Clinical;Clinical Trials;Collaborations;Communities;Complement;Dedications;Development;Discipline;Disease;Doctor of Philosophy;Drug Targeting;early experience;Educational workshop;Environment;Enzymes;Equilibrium;Event;experience;Faculty;Family;Financial Support;Funding;graduate student;Homeostasis;human disease;Immune;Individual;Industrialization;Industry;interest;International;Japanese;Joints;Knowledge;Learning;lectures;Malignant Neoplasms;meetings;Multienzyme Complexes;Mutation;Neurocognitive;new therapeutic target;next generation;North America;novel;novel strategies;Organ;Participant;Pathologic;Pathway interactions;Pharmaceutical Preparations;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiology;Play;Postdoctoral Fellow;posters;professor;programs;protein function;Protein Kinase;Protein phosphatase;Proteins;Recurrence;Regulation;Relaxation;Request for Applications;Research;Research Personnel;Resort;Role;Schedule;Science;Scientist;Series;Signal Pathway;Signal Transduction;social;Societies;Structure;symposium;System;Therapeutic;therapeutic target;Time;Tissues;Translational Research;Underrepresented Minority;Universities;Validation;Woman;Work

PROJECT_TITLE: Protein Phosphatases

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-E (M1)]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Congenital heart disease, or “holes in the heart,” is a major cause of infant death in the US. We investigate one possible cause of congenital heart disease, ion channels, that may affect the electrical properties of cells and heart development in the fetus.

PI_NAMEs: KHOKHA, MUSTAFA K (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Action Potentials;Address;Affect;Anatomy;Behavior;Biochemical;blastocyst;Breathing;Calcium;Calcium Channel;Cardiac;cardiogenesis;Cell Communication;Cell Differentiation process;cell fate specification;Cell Surface Receptors;Cells;Chemicals;Child;Child Health;cofactor;Collaborations;Computer Analysis;Congenital Abnormality;congenital heart abnormality;Data;Development;Disease;Ectoderm;electrical property;Electrophysiology (science);Elements;Embryo;embryo cell;Embryonic Development;Endoderm;Endoderm Cell;Fetus;forging;FRAP1 gene;gastrulation;Gene Expression;Genes;Genetic;Germ Layers;Goals;Heart;heart rhythm;Infant Mortality;intercellular communication;Ion Channel;knock-down;Ligands;Maintenance;Measurement;Membrane Potentials;Methods;Modeling;Morbidity - disease rate;mortality;Neurons;novel;Organ;Paraxial Mesoderm;Pathway interactions;Patients;Pattern;Play;pluripotency;Potassium Channel;Process;Property;prospective;Proteins;Publishing;Reagent;receptor;Receptor Signaling;regional difference;Rest;Role;Shapes;Signal Pathway;Signal Transduction;Specific qualifier value;stem cells;structural heart disease;Structure;Testing;Time;Tissue Differentiation;Tissue Engineering;Tissues;Traction;transcription factor;transmission process;voltage;Voltage-Gated Potassium Channel;Work;Xenopus

PROJECT_TITLE: The electrophysiological properties of embryos

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-M (02)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Mental Health;Mental Illness;Neurosciences;Substance Misuse

ORG_CITY: ATHENS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Narrative The extended amygdala plays complex roles in stress, anxiety, and drug/alcohol seeking behavior. This project will use preclinical rodent models to assess the impact of neuropeptides in the amygdala and nucleus accumbens, two key hubs in the extended amygdala, on anxiety-like behavior and alcohol consumption. We will analyze these effects using methods that allow for the manipulation of specific neurocircuits in the brain, as well as strategies that can assess gene expression changes in specific cell types.

PI_NAMEs: SCHANK, JESSE R (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Affinity;Affinity Chromatography;alcohol availability;Alcohol consumption;alcohol exposure;alcohol response;alcohol seeking behavior;alcohol use disorder;Alcoholism;Alcohols;Amygdaloid structure;Anatomy;Anhedonia;Anxiety;anxiety-like behavior;Behavior;Behavioral;behavioral phenotyping;behavioral response;biological adaptation to stress;Brain;Brain region;Calcium;Cell Nucleus;cell type;Cells;Characteristics;Chronic;chronic alcohol ingestion;comorbid depression;comorbidity;Complex;Consumption;depressive symptoms;Detection;Development;differential expression;drug of abuse;Exhibits;experimental study;Exposure to;Female;Fiber;follow up assessment;Funding;Future;Gene Expression;Genes;genetic approach;Genetic Transcription;Heavy Drinking;in vivo;Intake;interest;Limbic System;male;Measurement;Mediating;Mediator;Mental Depression;Messenger RNA;Methods;Modeling;Molecular;motivated behavior;Mus;nerve supply;neuroadaptation;neuronal patterning;Neurons;Neuropeptides;neurophysiology;neuropsychiatric disorder;novel;Nucleus Accumbens;Output;Pathway interactions;Pattern;Peptides;Pharmaceutical Preparations;Phase;Phenotype;Photometry;Play;pre-clinical;Proteins;Protocols documentation;receptor function;Receptor Signaling;Ribosomes;RNA;Rodent;Rodent Model;Role;Sex Differences;social;Social Behavior;social defeat;Social Interaction;social stressor;Source;Stress;Structure;Substance P;System;TACR1 gene;Testing;Thalamic structure;Time;Transcript;Translating;treatment strategy;Work

PROJECT_TITLE: The Neurokinin-1 Receptor as a Mediator of Alcoholism and Depression Comorbidity

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: A better understanding of the mechanisms that regulate CD8 T cell responses during chronic viral infection is required to improve immunotherapies that will increase T cell function and reduce viral load. Our studies will provide the fundamental basis for developing rational approaches for immunotherapy of chronic viral infections.

PI_NAMEs: AHMED, RAFI  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Address;Antigen-Presenting Cells;Antigens;Autoimmunity;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Chronic;chronic infection;Clinic;Collaborations;Combination immunotherapy;Combined Modality Therapy;Effector Cell;exhaust;Functional disorder;Goals;Health;Human;IL7 gene;Immunotherapy;improved;Infection;insight;Letters;Life Style;Lymphocytic choriomeningitis virus;Lymphoid;Lymphoid Tissue;Malignant Neoplasms;Mus;National Institute of Allergy and Infectious Disease;nonhuman primate;novel;Output;Pathway interactions;Play;Population;programmed cell death protein 1;Proliferating;receptor;Research Proposals;Resources;Role;Scientist;Sea;selective expression;self-renewal;Signal Transduction;Site;stem;stem cell differentiation;stem cells;T cell response;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Tissues;Transforming Growth Factor beta;United States National Institutes of Health;Viral Cancer;Viral Load result;Virus;Virus Diseases;Work

PROJECT_TITLE: T Cell Memory to Viruses

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Headaches;Migraine;Neurodegenerative;Neurosciences;Pain Research;Precision Medicine

ORG_DEPT: NEUROLOGY

PHR: NARRATIVE The proposed research will advance public health by discovering factors, such as biochemical and metabolic changes, underlying seizure initiation in people with drug-resistant epilepsy. This essential knowledge will revolutionize a new standard of care by forecasting and treating epileptic seizures in a population with few treatment options. The research is in line with the NIH / NINDS’ mission of seeking fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease.

PI_NAMEs: BAUD, MAXIME OLIVIER;EID, TORE ;RAO, VIKRAM RAMNATH;SPENCER, DENNIS D;ZAVERI, HITTEN P (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Accelerometer;Animals;Biochemical;Biochemical Pathway;Biological Markers;Brain;brain abnormalities;Brain Chemistry;Brain Diseases;brain electrical activity;Chemicals;Chemistry;Chronobiology;circadian;Circadian Rhythms;Clinical;clinical practice;Cluster Headache;Data;Disabling;Disease;Electrophysiology (science);empowerment;Epilepsy;Event;Exhibits;extracellular;Family;Fright;Future;gamma-Aminobutyric Acid;Goals;Hour;Human;Impaired cognition;improved;Individual;Injury;innovation;insight;Intractable Epilepsy;Isoleucine;Knowledge;Link;Metabolic;Metabolic Pathway;Metabolism;metabolome;Methods;Microdialysis;Migraine;minimally invasive;Mission;Monitor;Mood Disorders;Morbidity - disease rate;National Institute of Neurological Disorders and Stroke;Nervous System;Nervous System Disorder;neurophysiology;novel;Observational Study;Patients;Persons;Population;precision medicine;Premature Mortality;prevent;Probability;Prospective Studies;Public Health;Quality of life;Rain;Recurrence;Research;Research Personnel;Saliva;saliva sample;Salivary;sample collection;Seizures;social stigma;Societies;Specificity;standard of care;stem;Substance Use Disorder;System;Testing;Time;Uncertainty;United States National Institutes of Health;Weather

PROJECT_TITLE: Personalized Seizure Forecasting: A Precision Medicine Approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-T (02)]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Our project will develop a new platform technology for gene modulation in the CNS – a conjugate containing covalently linked siRNA and ASO domains. Building on our preliminary data that shows high safety and broad biodistribution in the CNS, we will first optimize the chemistry of this class of molecules, maximizing uptake in multiple CNS regions and cell types as well as overall efficacy and safety. We will then apply the approach to silence or rescue six pairs of genes, selected for their potential to provide synergistic benefit in ALS therapeutics.

PI_NAMEs: BROWN, ROBERT H.;WATTS, JONATHAN K (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Address;Adult;Age;age-related disease;ALS pathology;ALS patients;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Animal Model;Antisense Oligonucleotides;Architecture;arm;Biodistribution;Biological;Biological Availability;burden of illness;C9ORF72;cell type;Central Nervous System;Chemical Structure;Chemistry;clinical development;Clinical Trials;combinatorial;Complex;Data;Defect;design;Disease;disease phenotype;Drops;drug candidate;effective therapy;Elements;Epilepsy;familial amyotrophic lateral sclerosis;FDA approved;Gene Silencing;Genes;Genetic;Genetic Medicine;Huntington Disease;improved;in vivo;Individual;Induced pluripotent stem cell derived neurons;Inherited;innovation;insight;Investments;Laboratories;Lead;Length;Link;Measures;Mediating;Medicine;mitochondrial dysfunction;Molecular;Motor Neurons;mouse model;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurology;Neurons;oligonucleotide therapeutics;Oligonucleotides;Outcome;Parkinson Disease;Pathology;Pharmaceutical Preparations;phosphoramidate;phosphorothioate;Population;Positioning Attribute;protein TDP-43;Readiness;Regulation;Research;Ribonuclease H;RNA;RNA Interference;RNA Interference Therapy;RNA Splicing;Safety;Small Interfering RNA;Specificity;Spinal Muscular Atrophy;sporadic amyotrophic lateral sclerosis;stathmin;Structure;superoxide dismutase 1;synuclein;Technology;technology platform;Testing;Therapeutic;Therapeutic Agents;Therapeutic Index;therapy development;Toxic effect;transmission process;Tropism;uptake;Vertebral column;Work

PROJECT_TITLE: Multi-Targeting Oligonucleotide Therapeutics for Familial and Sporadic Amyotrophic Lateral Sclerosis

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative A rare pigmentary variant of the American black bear, the “glacier” bear, exhibits an unusual pattern of hair- greying. Our unpublished genetic association studies show that the glacier mutation maps to a single genomic region with a strong candidate gene, BCL2. We propose to confirm and extend the genetic findings, characterize the histologic and cellular basis of the glacier bear phenotype, and use functional genomic approaches in the corresponding human sequence to identify the causal variant and to better understand transcriptional regulation of BCL2.

PI_NAMEs: BARSH, GREGORY STEFAN (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Aging;Alaska;Animals;Apoptotic;BCL2 gene;Biological;Biological Assay;Black American;Black Bear;Candidate Disease Gene;causal variant;Cells;Chromosome 18;Code;Color;Complex;Control Animal;Data;Development;Distal;DNA;DNA analysis;Epithelium;Exhibits;Face;Fishes;Functional disorder;functional genomics;Genes;Genetic;genetic association;Genetic study;genome wide association study;Genomic approach;Genomic DNA;Genomic Segment;Genomics;Glacier;Hair;Hair follicle structure;Haplotypes;HepG2;Histologic;histological studies;Histology;Human;Human Cell Line;Human Chromosomes;Immunohistochemistry;insight;K-562;Kidney;KITLG gene;Laboratory mice;Length;Limb structure;loss of function;Lymphoid;Maps;Melanins;melanocyte;Modeling;Molecular;Mutation;Neurosecretory Systems;Organism;oxidative damage;Pattern;Phenotype;Physiological;Play;postnatal;Predisposition;Process;Proteins;psychosocial;Regulation;Regulatory Element;Reporter;Role;Sampling;Skin;skin biopsy;Specificity;stem cells;Tissues;Transcriptional Regulation;Untranslated RNA;Variant;whole genome;Wild Animals;Work

PROJECT_TITLE: Hair-greying and melanocytic regulation of BCL2 in a non-model organism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-V (02)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Social Determinants of Health;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative The 2024 European Behavioral Pharmacology Society workshop on Novel Pharmacotherapies for Substance Use Disorders: From Basic Science to Societal Implications will take place September 25-27, 2024 in Banff, Alberta, Canada. This meeting of around 150 international attendees will include cutting edge basic and preclinical science, and discussions of potential societal, ethical, and policy implications of new pharmacological interventions.

PI_NAMEs: DE WIT, HARRIET  (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Affect;Alberta province;Area;Award;Basic Science;behavioral pharmacology;Canada;Cannabinoids;career;Clinical;clinical application;clinical efficacy;Clinical Ethicists;Clinical Ethics;Clinical Research;Clinical Sciences;Collaborations;Collection;Data;Development;Discipline;Educational workshop;Environment;Ethics;European;Event;experience;Fostering;Foundations;Future;Gender;Geographic Locations;Geography;Goals;Hallucinogens;implementation intervention;Individual;innovation;insight;International;Intervention;Investigation;Journalism;Knowledge;laboratory experience;Legal Status;Lived experience;Location;marginalized population;Medical;Medical Journalism;meetings;Mentors;Molecular;Neuropeptides;next generation;novel;novel therapeutics;Participant;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Policies;policy implication;Postdoctoral Fellow;posters;pre-clinical;programs;Psilocybin;Public Health;Public Policy;Race;recreational drug use;Regulation;Request for Applications;Research;Research Personnel;Science;Scientist;Site;Societies;Stigmatization;student participation;substance use;Substance Use Disorder;substance use treatment;symposium;Time;translational applications;Translational Research;Travel;Treatment Efficacy;treatment research

PROJECT_TITLE: European Behavioral Pharmacology Society (EPBS) workshop on Novel Pharmacotherapies to Treat Substance Use Disorders: From Basic Science to Societal Implications

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 IXR-X (M1)]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Heart Disease;Lymphatic Research;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Narrative Mutations in CHD7 occur in patients with CHARGE syndrome that show craniofacial malformations and can also cause non-syndromic congenital heart diseases. The roles of CHD7 in the second heart field progenitors and lymphatic endothelial cells remain unclear. Our proposed research aims to provide new insights into the molecular mechanisms of CHD7 functions in the cardiac and craniofacial lymphatic vessels.

PI_NAMEs: LIEN, CHING-LING E (contact)

PROJECT_TERMS: Anterior;aortic arch;Area;atrioventricular septal defect;Beds;blind;Blood;Candidate Disease Gene;Cardiac;cardiogenesis;Cardiovascular system;Cell Nucleus;Cells;CHARGE syndrome;CHD7 gene;Chick;Chromatin;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;cleft lip and palate;Clustered Regularly Interspaced Short Palindromic Repeats;congenital heart abnormality;craniofacial;Craniofacial Abnormalities;craniofacial development;Data;Data Set;Defect;Development;Disease;Ductus Arteriosus;Embryo;Endothelial Cells;experimental study;Face;Fetal Heart;Fishes;Fluid Balance;gene conservation;Gene Expression;gene regulatory network;Genes;Genomics;Goals;Heart;Heart Ventricle;Homeostasis;Human;Image;Immune;innovative technologies;insight;Intercellular Fluid;islet;Knockout Mice;Laboratories;Larva;Lymph;lymph nodes;Lymphatic;Lymphatic Endothelial Cells;lymphatic malformations;Lymphatic System;lymphatic vessel;malformation;Mesoderm;Modeling;Molecular;Multiomic Data;multiple omics;Mus;mutant;Mutation;Myocardial;nuclease;Paralysed;Patients;pharynx muscle;Phenotype;Play;Population;Process;progenitor;Publishing;Reporting;Research;Resolution;Role;Siblings;Site;Smooth Muscle Myocytes;stem cells;Testing;therapeutic target;Tongue;transcriptome sequencing;transcriptomics;young adult;Zebrafish

PROJECT_TITLE: Chromatin remodeling factor CHD7 regulates cardiac and craniofacial lymphatic vessel development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-S (02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative The trajectory of Alzheimer’s disease progression is extremely heterogeneous, both spatially and temporally, which makes it challenging for patients and their families to plan for the future, for clinical research to target appropriate cohorts for clinical trials, and for scientists to investigate disease pathophysiology in a systematic manner. We will develop and validate an imaging prognostic score, termed the Tau Progression Index (TPI), to better predict the future accumulation of tau, neurodegeneration, and cognitive impairment, based on the subject’s individual brain structural and functional connectivity, as well as patterns of tau and amyloid deposition.

PI_NAMEs: BUTLER, TRACY A.;CHIANG, GLORIA CHIA-YI;RAZLIGHI, QOLAMREZA RAY (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: abeta accumulation;aged;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid beta-Protein;Amyloid deposition;Autopsy;Brain;Clinical;clinical application;Clinical assessments;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive testing;cohort;Communities;comorbidity;connectome;cost;Counseling;Data;Dementia;demographics;Deposition;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;disease prognosis;Disease Progression;effectiveness evaluation;Enrollment;extracellular;Family;Fingerprint;follow-up;functional decline;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Future;Generations;Genotype;Heterogeneity;Human;Image;Impaired cognition;Impairment;indexing;Individual;Laboratories;Magnetic Resonance Imaging;Measures;Methods;mild cognitive impairment;Modeling;Monitor;MRI Scans;multimodality;Nerve Degeneration;Network-based;Neurodegenerative Disorders;neuroimaging;neuropathology;Neuropsychology;non-demented;Onset of illness;Outcome;Participant;Pathology;Patients;Pattern;personalized medicine;personalized predictions;Positron-Emission Tomography;predictive marker;predictive modeling;Prognosis;prognostic;prognostic tool;Protocols documentation;radiotracer;recruit;remote interaction;Reporting;Research;Rest;Sampling;Scientist;Senile Plaques;Severity of illness;Structure;Subjects Selections;targeted treatment;tau aggregation;tau Proteins;Testing;Therapeutic Intervention;Thinness;Tracer;Uncertainty;United States National Institutes of Health;Validation;Vascular Diseases;Visit;Weight;Work;β-amyloid burden

PROJECT_TITLE: Tau progression index (TPI): An individualized predictor of Alzheimer's Disease trajectory based on subject-specific connectomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-W (02)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

PHR: PROJECT NARRATIVE Cell death is vital to several biological processes—from regulating proper development to protecting our bodies from pathogens, such as bacteria—and thus must be finely regulated and controlled. Many cell death pathways converge at a central hub, the RIPK1 protein, and we identified splicing factors that regulate RIPK1 and affect the outcome of cell death pathways. The proposed work will examine these splicing factors to advance fundamental knowledge of this biological pathway and enable targeted prevention and treatment strategies for the numerous diseases caused by dysfunction in cell death pathways.

PI_NAMEs: FITZGERALD, KATHERINE A.;LIEN, EGIL  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Acute;Affect;Alternative Splicing;Apoptosis;Bacteria;Biological;Biological Models;Biological Process;CASP8 gene;Cell Death;Cell Death Induction;Cell Line;Cells;CRISPR screen;Critical Pathways;cytokine;cytotoxic;cytotoxicity;Decision Making;design;Development;Disease;Exons;experimental study;Exposure to;Family member;Functional disorder;Gene Expression Profile;Genes;genome-wide;Host resistance;Immune;Immune response;In Vitro;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;inhibitor;Innate Immune Response;Knowledge;Macrophage;MAP3K7 gene;Mediating;Modeling;mouse model;mRNA Precursor;Mus;Natural Immunity;Nonsense Codon;Nonsense-Mediated Decay;novel;Outcome;pathogen;Pathway interactions;Phosphotransferases;Play;prevent;Prevention strategy;Process;Protein-Serine-Threonine Kinases;Proteins;receptor;receptor expression;Regulation;Resistance to infection;response;RNA Binding;RNA Splicing;Role;Shock;Signal Transduction;System;targeted treatment;TBK1 gene;Testing;Tissues;TNF gene;tool;treatment strategy;Variant;Work;Yersinia;Yersinia infections

PROJECT_TITLE: RNA splicing factor Raver1 controls cell death, inflammation, and innateimmunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (09)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Hypertension;Lymphatic Research;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Malfunction of the brain’s waste clearing glymphatic system has been shown to play a key role in cerebral small vessel disease (cSVD) the most common cause of cognitive impairment with chronic hypertension. Remarkably, the status of the lymphatic system (LS) has not been investigated in cSVD. We have novel data showing functional impairment of the LS in chronic hypertension and here we explore the novel idea that these pathological alterations contributes to cSVD.

PI_NAMEs: BENVENISTE, HELENE D (contact);EICHMANN, ANNE CHRISTINE;SANTAMBROGIO, LAURA ;THOMAS, JEAN-LEON

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Acceleration;Address;Affect;Age Months;Aging;aging population;Amlodipine;Anatomy;Animals;Anti-Hypertensive Agents;Arteries;Attention;Biochemical;blood pressure elevation;Blood Vessels;Brain;Brain Drains;Calcium;Cerebral small vessel disease;Cerebrum;Cervical;Cervical lymph node group;Chronic;Clinical;Collagen;Computer Analysis;Coupled;Coupling;Data;Deep Cervical Lymph Node;Defect;Dementia;Deposition;design;Development;Disease;disease model;Drainage procedure;draining lymph node;experimental study;Fluid Balance;Fluorescence Microscopy;Functional disorder;Functional impairment;functional status;gain of function;glymphatic dysfunction;glymphatic function;glymphatic system;Goals;Health;Hypertension;hypertensive;Image;imaging approach;Immunologic Surveillance;Impaired cognition;Impairment;Inbred WKY Rats;Intercellular Fluid;Light;Link;Liquid substance;lymph nodes;Lymphatic;Lymphatic Diseases;lymphatic drainage;lymphatic dysfunction;Lymphatic function;Lymphatic System;lymphatic vasculature;lymphatic vessel;Magnetic Resonance Imaging;Maps;Measures;Meningeal lymphatic system;Modeling;Molecular;molecular marker;Nerve Degeneration;Nodal;normotensive;novel;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Physiological;Play;Proteomics;Rat Strains;Rattus;Research Personnel;Role;Series;Sinus;Stroke;System;Techniques;Testing;Therapeutic;Time;tool;Vascular Cognitive Impairment;Vascular Endothelial Growth Factor C;wasting;Work

PROJECT_TITLE: Lymphatic drainage dysfunction in chronic hypertension


NIH_SPENDING_CATS: Aging;Chronic Obstructive Pulmonary Disease;Emphysema;Lung;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARATIVE In this proposal, we will test the central hypothesis that metformin, a common drug used in type 2 diabetes, protects against cigarette smoke (CS)-induced COPD by restoring lipid homeostasis and rescuing fatty acid oxidation (FAO) in alveolar type 2 (AT2) cells. We will use complementary in vitro and in vivo approaches to dissect the mechanisms by which metformin protects AT2 cells from FAO and restores mitochondrial metabolism, which is blunted by CS exposure, and to characterize the lipidomic profile of AT2 cells and blood samples from patients with COPD who have been using metformin. Our studies could stimulate the potential application of metformin in trials aimed at limiting emphysema progression in a selected subset of patients characterized by a specific lipidomic profile that could be targeted by metformin use.

PI_NAMEs: CLOONAN, SUZANNE M;POLVERINO, FRANCESCA  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Activities of Daily Living;acylcarnitine;age acceleration;Alveolar;Alveolar Cell Type I;alveolar epithelium;Alveolus;American;Apoptosis;Biguanides;Binding;Biological Aging;Biological Assay;Blood;Blood specimen;Carnitine Palmitoyltransferase I;Categories;Cell Aging;cell injury;Cell Line;Cell Physiology;Cells;Chronic Obstructive Pulmonary Disease;cigarette smoke;cigarette smoke-induced;cigarette smoke-induced COPD;Cigarette smoke-induced emphysema;cigarette smoke-induced lung injury;cigarette smoke-induced mitochondrial dysfunction;cigarette smoking;Clinical;cohort;Complex;conditional knockout;Data Set;Disease;Drug Targeting;Drug usage;Electron Transport;Ensure;Enzymes;Epithelial Cells;epithelial stem cell;Epithelium;exposure to cigarette smoke;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Freezing;Functional disorder;Genetic;Genomic Instability;Genus Hippocampus;Glucose;hallmarks of aging;healthspan;Homeostasis;Immunofluorescence Immunologic;Impairment;improved;In Vitro;in vivo;Individual;Inflammation;Injury;Knockout Mice;Knowledge;life span;lipid metabolism;lipidomics;Lipids;Lung;Lung Diseases;Lung Transplantation;Maintenance;Measures;Metabolic;Metabolic Pathway;Metformin;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial metabolism;Mitochondrial Proteins;Modeling;Morphology;mouse model;Mus;Natural regeneration;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Operative Surgical Procedures;oxidation;Oxidative Stress;Palmitates;Pathologic;Pathology;patient subsets;Patients;Phenotype;pre-clinical;Pre-Clinical Model;prevent;Production;progenitor;prospective;protective effect;Protein Isoforms;proteomic signature;Pulmonary Coin Lesion;Pulmonary Emphysema;pulmonary function decline;Pulmonary Pathology;Randomized, Controlled Trials;Recommendation;recruit;regeneration function;Regenerative capacity;Regulation;Respiration;respiratory;restoration;Role;Sampling;Seminal;senescence;Stress;surfactant;surfactant production;Tamoxifen;Testing;Therapeutic;Trans-Omics for Precision Medicine;Work;Yeasts

PROJECT_TITLE: Protective effects of metformin against cigarette smoke-induced lung pathologies via regulation of fatty acids metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (03)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The striatum receives both ascending and descending auditory inputs and is proposed to play a significant role in central auditory processing. However, fundamental questions about how specific auditory information is processed and integrated in the striatum and transformed into appropriate actions remain poorly understood. By focusing on the caudal striatum (TS) which receives intensive projections from auditory cortex, and investigating a previously unrecognized ascending pathway to TS, we aim to generate new insights into auditory processing in the striatum, and the findings may also enhance our understanding of the pathophysiology of auditory processing disorders as well as striatum-related neuropsychiatric disorders.

PI_NAMEs: ZHANG, LI I (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Anatomy;Area;Atlases;Auditory;Auditory area;auditory discrimination;Auditory Perception;Auditory Perceptual Disorders;auditory processing;awake;Behavior;Behavioral;Bilateral;Binaural;Brain;Calcium;Cell Nucleus;cell type;Corpus striatum structure;Cues;Decision Making;Discrimination;discrimination task;Dorsal;Electrophysiology (science);Fostering;Frequencies;Functional disorder;Genetic Models;Image;in vivo;Individual;Inferior Colliculus;insight;Investigation;Learning;Literature;Location;Midbrain structure;Monitor;mouse genetics;Mus;Names;Nature;neural circuit;Neurons;neuropsychiatric disorder;novel;optogenetics;Pathway interactions;Perception;Phase;Play;Positioning Attribute;Process;Property;response;Rewards;Role;sensory input;Signal Transduction;Slice;sound;sound frequency discrimination;Sound Localization;Source;Space Perception;stem;Stream;Synapses;Tail;Task Performances;Testing;Thalamic structure;Training;transmission process;Viral;Whole-Cell Recordings

PROJECT_TITLE: Contribution of striatum to central auditory processing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]


ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: PROJECT NARRATIVE  The 2024 Chemistry and Biology of Tetrapyrroles Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) will bring together a diverse group of researchers with common interests in understanding the chemistry and biology of tetrapyrroles and their importance in living organisms and the environment. Tetrapyrroles, which include heme, cobalamin (vitamin B12), chlorophyll and bilins, are a family of cofactors and metabolites that are essential to life on earth and integral to human health as they are necessary for nutrition, normal cellular function and homeostasis as well as disease states and immunology. The theme of the 2024 GRC and GRS are focused on role of tetrapyrroles in human health and disease processes along with the environment and will highlight the role of tetrapyrroles in understanding, treating, and preventing infectious and immunologic diseases, as well as understanding and treating rare diseases and advancing translational sciences through generalizable approaches to drug development and disease treatments.

PI_NAMEs: MEDLOCK, AMY ELIZABETH (contact)

PROJECT_TERMS: Address;Anemia;Area;Bacteria;Bilin;Biological;Biology;career;career development;Catalysis;Cell Physiology;Chemicals;Chemistry;Chlorophyll;Clinical;Cobalamin;cofactor;Collaborations;Communicable Diseases;Data;Development;Diabetes Mellitus;dietary heme;disability;Disease;drug development;Ensure;Environment;Equity;equity, diversity, and inclusion;experience;Family;Female;forging;Fostering;Goals;graduate student;Growth;Harvest;Health;Heme;Homeostasis;Hour;Human;Immune response;Immune System Diseases;Immunology;Individual;Industry;Infection;Inflammation;informal atmosphere;interest;International;Kidney Diseases;Lead;Life;Light;Medicine;meetings;Mentors;Metabolism;microbial;Microbial Biofilms;Mission;National Center for Advancing Translational Sciences;National Institute of Allergy and Infectious Disease;Nutrient;nutrition;Obesity;Ointments;Oral;Organism;Participant;Planet Earth;Plants;Play;Porphyrias;Postdoctoral Fellow;posters;prevent;Process;Production;professor;protein structure;Proteins;Rare Diseases;Recording of previous events;Regulation;Research;Research Personnel;Rhode Island;Role;Science;Scientist;Senior Scientist;Signal Transduction;Signaling Molecule;Source;symposium;Techniques;Tetrapyrroles;Time;tool;trafficking;Translational Research;undergraduate student;Underrepresented Minority;Universities;Vitamin B 12;Work

PROJECT_TITLE: 2024 Chemistry and Biology of Tetrapyrroles Gordon Research Conference and Gordon Research Seminar


NIH_SPENDING_CATS: Immunotherapy

ORG_CITY: SILVERTHORNE

ORG_NAME: KEYSTONE SYMPOSIA

ORG_STATE: CO

PHR: PROJECT NARRATIVE T cells are an important class of white blood cells that mediate immune responses by targeting foreign antigens throughout the body. Because T cells act in many tissues, the local microenvironment where they work plays an important role in T cell differentiation and action. This Keystone Symposia conference brings together a multidisciplinary group of researchers who are exploring the many ways in which surrounding tissue can influence T cell-based immune responses, including in therapeutic contexts, such as affecting the success of cancer immunotherapy.

PI_NAMEs: SHEPPARD, TERRY L. (contact)

PROGRAM_OFFICER_NAME: BARTELS, ADELINA EWURA-ABENA

PROJECT_TITLE: T Cell Differentiation in Tissue Microenvironments


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Genetics;Physical Activity;Prevention;Sleep Research

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Relevance to public health: Our modern 24/7 lifestyle is accompanied by prevalent perturbation of our daily rhythms in activity, eating and sleep, compromising health and fitness in the increasingly aging population. Focusing on our biological timer called circadian clock and particularly its core component RORs, the current project will interrogate circadian (epi)genetic regulatory mechanisms of RORs in age-related metabolic decline and explore timed exercise to promote skeletal muscle function and overall healthy aging. These studies promise to elucidate novel regulatory mechanisms and may ultimately lead to actionable strategies to improve the quality of life in the elderly.

PI_NAMEs: CHEN, ZHENG  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: 3-Dimensional;Acids;Adult;Age;age related;age related decline;aged;Aging;aging population;aging related;Agonist;Architecture;Behavioral;Bioenergetics;Biological;Biological Assay;Body Weight;chromatin immunoprecipitation;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Deceleration;Deterioration;Development;Disease;disease model;disorder risk;Eating;Elderly;Enhancers;Epigenetic Process;epigenetic regulation;epigenome;Exercise;exercise intervention;Exercise Tolerance;Fc Receptor;fitness;gain of function;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;Genomics;Hand Strength;Health;Health Promotion;healthspan;healthy aging;Hi-C;Histones;Homeostasis;Human;Impairment;improved;innovation;insight;Intervention;Intervention Studies;Knock-out;Knockout Mice;Knowledge;life span;Life Style;lifestyle intervention;Long-Term Effects;loss of function;LXRalpha protein;Metabolic;metabolic fitness;Metabolism;Methodology;middle age;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modernization;Molecular;Molecular Analysis;Mus;Muscle;muscle aging;Muscle Fibers;Muscle function;Muscle Mitochondria;Myoblasts;nobiletin;novel;Nuclear Receptors;old mice;Orphan;Periodicity;pharmacologic;Pharmacology Study;Phase;Physiological;Physiology;Play;Population;Production;promoter;Public Health;Quality of life;receptor;Records;Regulation;Reporter;Research Personnel;Respiration;respiratory;Retinoids;Role;Running;Skeletal Muscle;skeletal muscle metabolism;Sleep;Societies;Survival Analysis;Time;Tissues;transcriptomics;translational impact

PROJECT_TITLE: Circadian regulation of mitochondrial function by muscle RORs to promote healthy aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-S (02)]


ORG_CITY: COLLEGE STATION

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE This project explores how the heart removes harmful metabolic waste, reviving from failure.

PI_NAMEs: CHANG, JIANG  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Address;Age;Animal Genetics;Animal Model;Animals;Back;Biological;Biological Markers;Cardiac;Cardiac Myocytes;Cells;chemical reaction;clinically relevant;Collaborations;Consumption;CRISPR/Cas technology;cytotoxicity;Data;Death Rate;deep sequencing;Diagnostic;DNA Sequence Alteration;Down-Regulation;Drainage procedure;EFRAC;Electrons;Energy Metabolism;Ensure;Enzymes;epimerase;Exhibits;Failure;Functional disorder;Generations;Genes;Genetic;Heart;Heart failure;heart function;Histology;Human;human induced pluripotent stem cells;human subject;Hydration status;Hydro-Lyases;Impairment;improved;In Vitro;in vivo;innovation;Investigation;knock-down;Knock-out;Knockout Mice;Linear Models;Link;Mediating;Metabolic;Metabolic Pathway;metabolomics;Mitochondria;Modeling;Morphology;Mus;Muscle Cells;mutant;Myocardial;NADH;Niacinamide;novel;novel therapeutic intervention;novel therapeutics;Nucleotides;Pathogenesis;Pathogenicity;Pathologic;Patient-Focused Outcomes;Patients;Periodicity;Phenotype;Plasma;preservation;prevent;Prevention;Production;programs;Rare Diseases;Regulation;repaired;Research Personnel;Resources;Resuscitation;RNA;Role;sex;Signal Pathway;Stress;System;Technology;Testing;Therapeutic;Thinking;Tissues;Toxic effect;transcriptome;translational potential;Treatment Failure;Urine;wasting;Work

PROJECT_TITLE: Metabolic Resuscitation in Heart Failure.

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Biotechnology;Kidney Disease

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The goals of this project are to better understand the pathogenesis of proteinuric kidney disease so that targeted new treatments can be designed. Podocyte shape and adhesion to the glomerular basement membrane are critical for maintaining the integrity of the glomerular filtration barrier, which prevents the loss of blood proteins into the urine. The current proposal aims to gain a deeper mechanistic understanding of the components and dynamics of the podocyte's cytoskeleton so that we can better understand how podocytes maintain their unique shape and adhesion within the glomerulus.

PI_NAMEs: GENIN, GUY M;MINER, JEFFREY H (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Actinin;Actins;adhesion process;Adhesions;Adriamycin PFS;Affect;Architecture;base;Binding Proteins;Biochemical;Biology;Blood Proteins;CD2-associated protein;Cell Culture Techniques;Cell Line;Cells;Cellular Structures;Chronic;Chronic Kidney Failure;Compensation;Cytoskeleton;Data;design;Development;Disease;disease model;Electrons;Endothelium;Ensure;experimental study;Exposure to;Family;Filtration;foot;Foot Process;Functional disorder;glomerular basement membrane;glomerular filtration;Goals;healing;Health;Hemorrhage;Hereditary nephritis;Homeostasis;human disease;human model;Hydrogels;hypertensive;Image;Impairment;improved;improved outcome;In Vitro;in vivo;injured;Injury;innovation;insight;Integrin Binding;Integrins;Kidney;Kidney Diseases;Kidney Failure;Knock-out;Knockout Mice;Ligands;Light;Liquid substance;Maintenance;mechanical force;Microscopic;Modeling;Monomeric GTP-Binding Proteins;mouse model;Mus;mutant mouse model;Nephrotic Syndrome;Nonmuscle Myosin Type IIA;novel;novel therapeutics;optogenetics;Pathogenesis;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Patients;Physiological;podocyte;Population;Predisposition;prevent;Process;Proteinuria;recruit;Regulation;Renal glomerular disease;Research;response;response to injury;rho;Risk;Role;Sarcomeres;Shapes;slit diaphragm;Stress;Structure;synaptopodin;System;targeted treatment;Testing;Therapeutic;translational potential;Urine;Visualization;Work

PROJECT_TITLE: Revealing New Therapeutic Opportunities for Kidney Glomerular Diseases by Elucidating the Mechanobiological Functions of Novel Cytoskeletal Structures in Podocytes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-W (04)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health

PHR: Project Narrative Venomous animals have been the source and inspiration for several breakthrough drugs for treating pain, diabetes, epilepsy, and hypertension, yet their full potential remains untapped. The 2024 Gordon Research Conference and Seminar on Venom Evolution, Function and Biomedical Applications is an innovative program focused on venom diversity that integrates the conceptual perspective of evolutionary biologists, ecologists, and clinicians with the methodological expertise of toxinologists and analytical scientists, connecting basic research on venomous taxa to both translational application of venoms and the development of novel treatments of envenoming. Ultimately, this research benefits human health and makes socio-economic impacts possible through advancing biomedical research and therapeutic drug discovery and development.

PI_NAMEs: MACKESSY, STEPHEN P (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Address;Animals;Anticoagulation;Applied Research;Area;Basic Science;Biological Models;Biological Sciences;Biology;Biomedical Research;Biotechnology;Breathing;career;Categories;Classification;Clinical;Collaborations;Communication;Communities;Complex;Coupled;Dedications;Development;Diabetes Mellitus;Discipline;drug development;drug discovery;early-career faculty;Ecology;economic impact;Economics;Environment;Epilepsy;ethnic diversity;Evolution;Faculty;Fostering;frontier;Future;gender diverse;General Population;Genomics;global health;Goals;graduate student;Health;health economics;Human;human disease;Human Pathology;Hypertension;Iceberg;Impairment;Industry;innovation;interdisciplinary approach;Ion Channel;Ion Channel Gating;Knowledge;Life;Ligands;Link;medical specialties;Medicine;meetings;Methodology;Molecular;Molecular Structure;Molecular Target;National Center for Complementary and Integrative Health;Natural Sciences;neglected tropical diseases;novel;novel therapeutics;Outcome;Pain;Participant;peptide drug;Peptides;Pharmaceutical Preparations;pharmacologic;Physiological;Postdoctoral Fellow;Predatory Behavior;Prevention strategy;programs;Protein Engineering;Proteomics;Publications;receptor;Research;research and development;response;Route;scalpel;Science;Scientist;socioeconomics;Source;Study models;symposium;Targeted Toxins;Taxonomy;Technology;Therapeutic;therapeutic development;Time;tool;Toxin;trait;Translating;translational applications;Trees;Venoms;voltage;World Health Organization

PROJECT_TITLE: 2024 Venom Evolution, Function and Biomedical Applications Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (05)]