ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Around 200,000 individuals were sickened in the first Gulf War. That the symptoms persist in most to this day suggests that there are epigenetic changes in the genomes. This work seeks to identify which genes have been so modified in a mouse model and thereby help direct diagnosis and treatment.

PI_NAMEs: JONES, BYRON C (contact);OCALLAGHAN, JAMES P

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Acetylcholinesterase Inhibitors;Acute;Age Months;animal data;Animal Model;Animals;Bayesian Network;Bioinformatics;Biological;Biological Markers;Candidate Disease Gene;Combined Modality Therapy;Complex;Control Locus;Corticosterone;Cytokine Gene;Data;design;Diagnosis;Disease;Dissection;DNA Methylation;Endocrinology;Environment;Epigenetic Process;Etiology;Euthanasia;Exposure to;Family;fluorophosphate;gastrointestinal;gene environment interaction;Gene Expression;Gene Expression Regulation;gene network;Genes;Genetic;genetic analysis;Genetic Markers;Genetic Variation;Genome;genomic locus;Genotype;Glucocorticoids;Goals;Gulf War;Hippocampus;histone modification;Human;Inbred Mouse;Inbred Strains Mice;Inbreeding;Individual;Individual Differences;Inflammatory;insertion/deletion mutation;learning network;Link;Long-Term Effects;Malaise;Maps;Measures;Mediating;Methylation;Modeling;Molecular;mouse model;Mouse Strains;Mus;Names;Neurologic;novel;Organophosphorus Compounds;Pathway Analysis;Pathway interactions;Persian Gulf;Persian Gulf Syndrome;phenome;Phenotype;Physiological;Population;Predisposition;Prefrontal Cortex;Proteome;Quantitative Trait Loci;Recombinants;Research;Resources;respiratory;response;Stress;Symptoms;System;transcriptome;treatment response;Update;Variant;Work

PROJECT_TITLE: Genetics of epigenetic response to high circulating glucocorticoids and organophosphorus compounds

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: OD

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: COLUMBIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PI_NAMEs: BRYDA, ELIZABETH C (contact)

PROJECT_TERMS: Acceleration;Affect;Amino Acids;animation;Applied Research;Archives;Area;base editing;cost;cost effective;CRISPR/Cas technology;cryobiology;Cryopreservation;Data;Development;Embryonic Development;embryonic stem cell;Ensure;experience;experimental study;Extinction;Fertilization;Fertilization in Vitro;Freezing;Funding;Future;Gene Modified;Generations;Genes;genetic manipulation;genome editing;Germ;Goals;improved;In Vitro;Inbred Strain;Incubated;Injections;Intracytoplasmic Sperm Injections;knockout animal;Laboratory Research;Letters;Measures;Methods;Modeling;Motility;Mus;Mutagenesis;novel;nuclease;oocyte maturation;Oocytes;operation;Outcome;Outcome Measure;preservation;Protocols documentation;Publishing;Qualifying;Rat Strains;Rattus;Renaissance;Reporting;reproductive;Reproductive Biology;Research;Research Personnel;Resources;Sperm Capacitation;sperm cell;sperm cryopreservation;Sperm Motility;Spermatogenesis;success;Supplementation;Techniques;Technology;Testing;transcription activator-like effector nucleases;Transgenic Organisms

PROJECT_TITLE: Project

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-A]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cachexia;Cancer

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative A well-documented long lasting toxicity of chemotherapy agents is their capacity to cause or intensify cancer- associated muscle wasting and fatigue, manifestations of cachexia. The current project is designed to elucidate the cellular mechanisms through which chemotherapy drugs 5-FU and cisplatin potentiate the capacity of cancer cells to induce muscle wasting in mouse models of cancer. In addition, experimental therapy will be carried out by repurposing existing pharmacological agents to target 5-FU/cisplatin stimulation of cancer-associated muscle wasting through the mechanisms discovered by this project specifically.

PI_NAMEs: LI, YI-PING  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Address;Animals;antagonist;C26 tumor;Cachexia;Cancer Cachexia;cancer cell;Cancer Model;Cancer Patient;cancer survival;cancer therapy;Catabolism;Chemosensitization;chemotherapy;Chemotherapy-Oncologic Procedure;Cisplatin;Clinical;Clinical Research;Colon Carcinoma;Complication;cytokine;Data;design;Development;Dose;Drug usage;Etiology;experience;extracellular vesicles;FDA approved;Fluorouracil;Functional disorder;Future;Genetic Transcription;Human;Impairment;In Vitro;in vivo;Inflammatory;inhibitor;Intervention;Investigational Therapies;Knowledge;Lewis Lung Carcinoma;Mainstreaming;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metabolic Diseases;Mitochondria;mitochondrial dysfunction;Modeling;Monomeric GTP-Binding Proteins;Morbidity - disease rate;mortality;mouse model;multicatalytic endopeptidase complex;Mus;Muscle;Muscle Cells;Muscle Fatigue;Muscle Proteins;Muscular Atrophy;NF-kappa B;novel;novel therapeutics;Omeprazole;Oxidative Stress;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pilot Projects;prevent;protein degradation;Proton Pump Inhibitors;Pump;Quality of life;Serum;Signal Transduction;Skeletal Muscle;success;Testing;Therapeutic;TLR4 gene;Toxic effect;Toxicity due to chemotherapy;Treatment Protocols;treatment strategy;tumor;Ubiquitin;Up-Regulation;vesicular release;wasting

PROJECT_TITLE: Mechanism of chemotherapy potentiation of muscle wasting in cancer cachexia

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative: Because glucocorticoids, the main therapeutic option for most primary glomerular diseases, are limited by severe systemic toxicities, there is an urgent need in nephrology to replace their use with novel podocyte-targeted therapies or at the very least, to identify in advance of their administration, the subset of patients who are likely be glucocorticoid responsive. This project identifies the essential podocyte gene DACH1 as a central transcriptomic regulator of the salutary glomerular glucocorticoid response and analyzes involved mechanisms with the goal of identifying novel therapeutic approaches. This work will also correlate a prevalant intronic locus, which our data show augments DACH1 transcription in the setting of glucocorticoid therapy, with clinical outcomes in glucocorticoid-treated primary glomerular disease patients, a clinically important observation that may allow for better individualized risk-benefit stratification prior to initiating glucocorticoid therapy.

PI_NAMEs: KAUFMAN, LEWIS  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Adriamycin PFS;Alleles;Benefits and Risks;Binding;Binding Proteins;Binding Sites;Cell Line;chromatin immunoprecipitation;Clinical;cohort;Data;design;Disease;Enhancers;Event;Focal and Segmental Glomerulosclerosis;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;genome wide association study;Genotype;Glucocorticoid Receptor;Glucocorticoids;Goals;Heterozygote;Human;human induced pluripotent stem cells;immunoregulation;improved;In Vitro;in vivo;Injury;Kidney Diseases;Kidney Transplantation;Knockout Mice;Link;Mediating;mouse model;Mus;Mutation;Nephrology;Nephrotic Syndrome;novel;novel therapeutic intervention;Outcome;overexpression;patient subsets;Patients;Phenotype;podocyte;Predisposition;preservation;promoter;protective allele;Proteinuria;receptor binding;Regulation;Renal glomerular disease;Reporter;Resistance;resistance allele;response;risk variant;Signal Transduction;Single Nucleotide Polymorphism;Stratification;Susceptibility Gene;systemic toxicity;targeted treatment;Testing;Therapeutic;Toxic effect;transcription factor;transcriptome;transcriptomics;Transgenic Mice;Transplant Recipients;treatment choice;Up-Regulation;Work

PROJECT_TITLE: DACH1 transcriptomic regulation of glucocorticoid-responsive glomerular disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN ANTONIO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Alzheimer's disease is the most common form of dementia in the elderly and represents a major health crisis. Age is the most important risk factor in Alzheimer's disease, but the disease is also influenced by environmental factors, individual experience and genetic pre-deposition. This application seeks to understand the role of a splicing regulator and GWAS risk factor in Alzheimer's disease. The proposed work will provide the first functional evidence for the role of CELF RNA binding protein in neurodegenerative diseases and will suggest potential biomarkers and therapeutic targets.

PI_NAMEs: CHEN, LIZHEN  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Adult;Affect;Age;Aging;Alleles;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Animal Model;Animals;Autopsy;Behavior;Behavioral;Binding;Biochemical;Brain;brain cell;Brain region;Caenorhabditis elegans;calmodulin-dependent protein kinase II;cell type;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;comparison control;conditional knockout;crosslink;crosslinking and immunoprecipitation sequencing;Data;Defect;Dementia;Deposition;Disease;Elderly;Environmental Risk Factor;Exons;experience;Family;Genes;Genetic;genetic analysis;genetic association;Genetic Polymorphism;Genetic Screening;genetic variant;genome wide association study;Genomics;Health;high risk;High-Throughput Nucleotide Sequencing;Hippocampus;Homologous Gene;hTau Mice;Human;Human Genetics;human induced pluripotent stem cells;Immunohistochemistry;Immunoprecipitation;Impaired cognition;improved;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;insight;Introns;knock-down;Knock-in;Knock-out;Knockout Mice;Late Onset Alzheimer Disease;Learning;Longevity;Mammals;MAPT gene;Measures;member;Memory;Messenger RNA;Microtubules;Minor;Modeling;mouse model;mRNA Expression;Mus;mutant;Mutation;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neurons;neurotoxicity;new therapeutic target;overexpression;Pathogenesis;Pathology;Patients;Phenotype;Play;potential biomarker;presenilin-1;presenilin-2;protective effect;protein expression;Protein Isoforms;Proteins;Publishing;Regulation;Reporting;Research;Risk Factors;Risk Reduction;risk variant;RNA Splicing;RNA Stability;RNA-Binding Proteins;Role;Sampling;Single Nucleotide Polymorphism;Spinal Muscular Atrophy;tau expression;tau Proteins;Tauopathies;Techniques;Testing;therapeutic target;Tissues;transcriptome sequencing;Work

PROJECT_TITLE: The role of CELF2 and its genetic variants in Alzheimer's disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

ORG_STATE: CA

PHR: We find that DSBs may be are killing brain cells in Huntington disease and that differential repair in astrocytes and neurons account for their sensitive to death. We will apply “Repair Fingerprinting” as a powerful and integrated approach to link DNA repair to toxicity.

PI_NAMEs: POLYZOS, ARIS A (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acceleration;Accounting;Acute;Affect;Age;Animals;Antioxidants;arm;Astrocytes;Attenuated;Brain;brain cell;Brain Diseases;CAG repeat;Cell Death;cell type;Cells;Cessation of life;chemical fingerprinting;Chemicals;Conceptions;Corpus striatum structure;disabling disease;Disease;disease phenotype;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;Early identification;early onset;Equilibrium;fatty acid oxidation;Fingerprint;Funding;Genes;genome wide association study;genome-wide;Goals;Huntington Disease;In Vitro;in vivo;Individual;Lead;Lesion;Link;Mass Spectrum Analysis;Metabolic;Mitochondria;Modeling;mouse model;Mus;mutant;neuron loss;Neurons;novel strategies;Onset of illness;oxidative damage;oxidative DNA damage;Pathway interactions;Patients;Predisposition;Process;protein protein interaction;Proteins;Reactive Oxygen Species;repair model;repaired;Reporting;Role;Scaffolding Protein;Stress;System;Testing;Therapeutic;Time;Toxic effect

PROJECT_TITLE: Chemical Fingerprinting

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Cryptococcosis is estimated to account for about 15% of AIDS-related deaths annually; a vaccine is not available. A genetically engineered heat-killed Cryptococcus neoformans vaccine strain protect mice against lethal fungal challenge, even if the mice mimic the T cell deficiency found in AIDS. The proposed preclinical research is designed to develop a mechanistic understanding of the immunological and vaccine determinants of protection, and thus bring us closer to having a vaccine ready for human testing.

PI_NAMEs: LEVITZ, STUART MICHAEL;LODGE, JENNIFER K. (contact);SPECHT, CHARLES A

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS Vaccines;AIDS-Related Opportunistic Infections;anti-fungal agents;Antigens;CD4 Positive T Lymphocytes;Cell Count;cell type;Cells;Cessation of life;Chitin deacetylase;Chitosan;Compensation;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;cytokine;Data;Dendritic Cells;design;Development;Disparate;Effector Cell;Exhibits;falls;Funding;Future;Generations;Genes;Genetic Engineering;global health;Goals;HIV;Human;Immune response;Immunity;Immunologics;Individual;Infection;Inflammatory;Inflammatory Response;Ligands;Macrophage;manufacture;Mediating;mucosal vaccine;Mus;mutant;Nature;Patients;Persons;Phase;Populations at Risk;pre-clinical;pre-clinical research;preclinical study;Production;Pulmonary Inflammation;recruit;research clinical testing;response;Risk;Role;T-Cell Depletion;T-Lymphocyte;Testing;Time;tool;Vaccinated;Vaccination;Vaccine Design;vaccine development;Vaccines;Variant

PROJECT_TITLE: Preclinical studies of a Cryptococcus vaccine for AIDS patients

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Narrative Immune therapy has shown great promise in the control of many cancers. However, it has been ineffective in Pancreatic Cancer and we hypothesize that this is due, in part, to the extremely acidic milieu that is present in pancreatic cancer. We have shown that neutralization of acidity in mouse models of pancreatic cancers can improve immune therapy and, in this proposal, we will develop methods that can be clinically translated with the expectation that this information will lead to clinical trials to improve immune therapy in pancreatic cancer patients.

PI_NAMEs: IBRAHIM HASHIM, ARIG A;PILON-THOMAS, SHARI  (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Acidity;Acidosis;Acids;Address;Affect;anti-CTLA4;anti-PD-1;anti-PD-L1;anti-tumor immune response;Bicarbonates;Biodistribution;Bolus Infusion;Buffers;cancer cell;Carbon Dioxide;Cell Line;Cells;Chemicals;Clinical;clinical translation;Clinical Trials;Clinical Trials Design;Cytoplasm;Data;Dose;Drops;Drug Kinetics;effector T cell;efficacy evaluation;Engineering;enzyme activity;expectation;extracellular;Female;Fibroblasts;Flow Cytometry;fluorodeoxyglucose positron emission tomography;Glycolysis;Glycolysis Inhibition;Habitats;Image;imaging biomarker;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immunocompetent;Immunotherapy;Impairment;Implant;improved;In Situ;in vivo;Injections;Knowledge;KRASG12D;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;male;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Melanoma;Metabolic;Methods;Modeling;molecular imaging;Monitor;mouse model;Mus;neoplastic cell;nuclear factors of activated T-cells;Oral;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Perfusion;PET/CT scan;Pharmacodynamics;Phase;Physiological;Positron-Emission Tomography;programmed cell death ligand 1;programmed cell death protein 1;radiomics;Resistance;Respiration;response;response biomarker;Schedule;secondary endpoint;Signal Transduction;System;T cell therapy;T-Cell Activation;T-Lymphocyte;Taste Perception;Testing;Therapeutic;therapy design;Time;Transactivation;Translating;treatment effect;tumor;tumor growth;Tumor-Derived;tumor-immune system interactions;Urea;Urease;Work

PROJECT_TITLE: Imaging Acidosis and Immune Therapy in PDAC

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The inability to clinically treat cancer metastasis is responsible for the majority of patient deaths from solid tumors, including breast cancer. Cell migration is a pivotal step in the metastatic dissemination of cancerous cells from a primary tumor to distant organs in the body. We herein employ a multidisciplinary approach, which integrates state-of-the-art bioengineering and imaging tools, quantitative analysis and in vivo models, to offer a comprehensive understanding of the mechanisms driving breast cancer cell migration in physically-confined spaces and identify novel therapeutic targets to reduce breast cancer metastasis.

PI_NAMEs: KONSTANTOPOULOS, KONSTANTINOS  (contact);MARTIN, STUART S

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: 3-Dimensional;Actins;Actomyosin;Affect;Automobile Driving;Biological Models;Biomedical Engineering;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Cancer Biology;cancer cell;Cancer Patient;Cancerous;Cell Cycle;Cell membrane;cell motility;Cell Separation;Cell surface;Cell Volumes;Cells;Cellular biology;Cessation of life;Clinical;combat;Complement;Confined Spaces;Cytoplasm;Cytoskeleton;Data;Dissociation;Distant;Elements;Event;experimental study;Extracellular Matrix;Fatty acid glycerol esters;Fiber;fluid flow;Gel;Goals;Growth;Image;Imaging Device;In Vitro;in vivo;in vivo Model;Individual;innovation;Integrins;interdisciplinary approach;interstitial;Intracellular Transport;intravital microscopy;Ion Channel;Ions;Light;live cell imaging;Malignant Breast Neoplasm;mammary;mathematical model;Mediating;Metastatic breast cancer;Microfluidic Microchips;Microtubules;migration;Modeling;Molecular;Molecular Biology;Motility;mouse model;multiphoton microscopy;Mus;Myosin Type II;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Optics;optogenetics;Organ;Organoids;Osmosis;patient derived xenograft model;Patients;Phase;Primary Neoplasm;Regulation;Research Personnel;Role;Solid Neoplasm;Swelling;targeted treatment;Testing;therapeutic target;Tissues;tool;Transplantation;Travel;triple-negative invasive breast carcinoma;tumor;Tumor Cell Migration;tumorigenic;Water;water channel;Work;Zebrafish

PROJECT_TITLE: The interplay of ion transporters and cytoskeleton in breast cancer migration and metastasis

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE — RELEVANCE TO PUBLIC HEALTH Rectal cancer affects 40,000 people per year in the US. Unfortunately, approximately 85 % of patients have an incomplete or poor response to chemoradiotherapy treatment, which increases their risk or recurrence and metastasis. This project will study a previously unknown mechanism of resistance to treatment in rectal cancer with the potential to lead to development of novel therapeutics that could be relevant to both rectal cancer and other similarly treated gastrointestinal cancers in the future.

PI_NAMEs: HARDIMAN, KARIN MARIE (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Adenocarcinoma;Affect;Aftercare;Apoptosis;Apoptotic;beta-site APP cleaving enzyme 1;cancer cell;Cancer cell line;Cancer Etiology;Cancer Model;Cell Separation;Cell surface;Cell Survival;cell type;Cells;Cessation of life;Charge;chemoradiation;Data;Development;Enzymes;extracellular vesicles;functional gain;Future;gastrointestinal;Genetic Transcription;Glycoproteins;glycosylation;glycosyltransferase;Golgi Apparatus;Human;Immunohistochemistry;Individual;Inhibition of Apoptosis;inhibitor;inorganic phosphate;knock-down;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mediating;Mediator;Membrane Lipids;Messenger RNA;Modeling;Neoplasm Metastasis;novel;novel therapeutics;Organoids;overexpression;particle;patient response;Patients;Persons;Primary Neoplasm;protein function;Proteins;Public Health;radiation resistance;receptor;Rectal Cancer;Rectal Neoplasms;Recurrence;Regulation;Research;Resistance;resistance mechanism;response;Risk;RNA;Role;Sampling;Sialic Acids;sialylation;single cell sequencing;small hairpin RNA;Sorting;standard of care;Structure;sugar;Testing;Therapeutic;therapy resistant;Tissues;TNFRSF1A gene;trafficking;treatment response;tumor;Tumor Promotion;vector

PROJECT_TITLE: A novel, transferable sialylation-mediated mechanism of chemoradioresistance in GI cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Primary ciliary dyskinesia (PCD) is a genetic disease caused by the failure of cilia to beat, leading to recurrent infections and chronic lung disease, for which there is no treatment. Our proposed project will investigate the motor proteins that supply the force for cilia beating and are mutant in PCD. We will determine the how the cell handles mutant motor proteins to identify shared pathways that could be therapeutically manipulated to treat PCD in the early course of disease.

PI_NAMEs: HORANI, AMJAD  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Advisory Committees;Affect;Airway Disease;Area;Autophagocytosis;biological adaptation to stress;Biology;Biopsy;Bronchiectasis;career;Cells;Cellular Stress;Chronic;Chronic lung disease;Chronic Sinusitis;Cilia;cilium biogenesis;cilium motility;Client;Clinic;Code;Collaborations;Complex;Cystic Fibrosis;Cytoplasm;Data;Data Analyses;Defect;Dextrocardia;differential expression;Disease;Dynein ATPase;Endogenous Factors;Ensure;Epithelial Cells;Excision;Exogenous Factors;Failure;Fluorescence;Fluorescence Resonance Energy Transfer;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Diseases;Genetic Transcription;Genomics;Goals;Handedness;Health;Heat shock factor;Heat-Shock Response;Heterozygote;Homeostasis;IL6 gene;Image;Immunoprecipitation;Impairment;improved;In Vitro;Infection;Infertility;Inflammation;International;Interruption;Knowledge;Lead;Link;Lung;Mentors;Methods;microscopic imaging;Microscopy;Motility;Motor;Mucociliary Clearance;multicatalytic endopeptidase complex;mutant;Mutate;Mutation;Nasal Epithelium;Neonatal Respiratory Distress;Nose;novel strategies;novel therapeutics;Other Genetics;Otitis Media;Parents;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Physicians;prevent;Primary Ciliary Dyskinesias;protein aggregation;Protein Analysis;Proteins;Proteomics;proteostasis;Rare Diseases;recurrent infection;Regulation;Research;Research Personnel;Respiratory Failure;response;Role;scaffold;Scientist;single cell sequencing;skill acquisition;Spectrum Analysis;Stress;Syndrome;System;Technical Expertise;Testing;Therapeutic;Training;transcriptome sequencing;Ubiquitin;Work

PROJECT_TITLE: The Role of Dynein Motor Mutations in Motile Cilia Disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Diabetes;Genetics;Human Genome;Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative: There is a close relationship between diabetes and periodontitis. Although this relationship is very well documented we do not have a clear understanding of the mechanisms by which diabetes enhances the severity and risk of periodontitis. We will investigate a novel mechanism that examines diabetes-altered dendritic cell activity in contributing to periodontitis using state-of-the-art techniques.

PI_NAMEs: GRAVES, DANA T (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: adaptive immune response;Affect;Animals;Apical;Area;Bacteria;Bacterial Infections;Behavior;Bioinformatics;bone;Bone Resorption;Candidate Disease Gene;Cell Communication;Cell Physiology;cell type;Cells;Connective Tissue;Coupled;Data;Data Analyses;Data Set;Dendritic Cells;Diabetes Mellitus;diabetic;Disease;Disease Progression;Disease susceptibility;dysbiosis;Epithelium;Event;experimental study;follow-up;Frequencies;functional outcomes;Gene Expression;Gene Expression Profile;Genes;Gingiva;Human;Immune response;Immunofluorescence Immunologic;improved outcome;In Vitro;in vivo;Inflammatory;inhibitor;insight;Leukocytes;Location;Methods;microbial;mouse model;Mus;novel;oral cavity epithelium;Osteogenesis;Pattern;Periodontal Diseases;Periodontitis;Periodontium;Phenotype;pre-clinical;Predisposition;recruit;Regulatory T-Lymphocyte;response;Risk;Role;Severities;single-cell RNA sequencing;small molecule;Spatial Distribution;Specimen;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;transcriptomics;translational study

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: NEUROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Alzheimer disease (AD) and related tauopathies are major diagnostic, therapeutic, and clinical challenges. Transcellular propagation of tau pathology is hypothesized to mediate the progression of disease, and our prior work has implicated binding to heparan sulfate proteoglycans (HSPGs) as a critical first step. Our study seeks to test the role of binding to HSPGs in the progression of tau pathology in mouse models, to determine how, once bound to the cell surface, that pathological tau assemblies gain entry to the cell, and the specificity of this process for tau vs. other pathological amyloid proteins, α-synuclein and TDP-43.

PI_NAMEs: DIAMOND, MARC I (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 3-Dimensional;aggregation pathway;alpha synuclein;Alzheimer's Disease;Amyloid;Amyloid Proteins;Animal Model;Bilateral;Binding;Biosensor;brain cell;Brain region;cell immortalization;Cell Line;Cell membrane;Cell model;Cell surface;Cells;Clinical;CRISPR screen;Cultured Cells;Cytoplasm;Development;Diagnostic;Disease;Disease Progression;Endocytosis;endosome membrane;Enzymes;extracellular;feasibility testing;Fluorescence Resonance Energy Transfer;fluorophore;frontal lobe;Genes;Grant;Health;Heparan Sulfate Proteoglycan;Heparitin Sulfate;HIV;Image;Immunotherapy;in vivo;in vivo evaluation;Induced pluripotent stem cell derived human neuron;Injections;knock-down;Lipofectamine;Mediating;Membrane;Methods;Modeling;Modification;Molecular Conformation;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;novel therapeutic intervention;novel therapeutics;Pathologic;Pathology;Pathway interactions;Peptides;Play;prevent;Process;Productivity;Propidium Diiodide;Protein Isoforms;protein TDP-43;Proteins;Publishing;Role;selective expression;self assembly;Shapes;Specificity;Structure;sugar;Sulfate;synuclein;System;tau aggregation;tau mutation;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutic development;therapy development;trafficking;Transfection;transmission process;uptake;Validation;vector;Vesicle;whole genome;Work

PROJECT_TITLE: Mechanism of cell uptake for pathogenic tau seeds


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative We have discovered a novel mechanism by which aggressive breast cancer cells give rise to a secretome consisting of exosomes with unique protein cargo and soluble cathepsins that stimulates the migration and invasive activity of cells, and thus increases their potential for metastatic spread. This mechanism involves the coordination between the down-regulation of the NAD+-dependent deacetylase Sirtuin 1 (SIRT1) and the glutamine addiction characteristic of breast cancer cells. In the proposed studies, we will determine how these changes in SIRT1 expression/activity and cancer cell metabolism work together to drive metastatic spread with the over-riding goal of identifying new potential strategies to intervene against breast cancer metastasis.

PI_NAMEs: ANTONYAK, MARC A (contact);FISCHBACH, CLAUDIA ;WEISS, ROBERT S

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: 3-Dimensional;Acetylation;addiction;Affect;aggressive breast cancer;Automobile Driving;Biochemical;Biogenesis;Biological Models;Biology;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;Cancer Biology;cancer cell;Cathepsins;Cell surface;Cells;Cellular Assay;Characteristics;Chemicals;Cues;Databases;Deacetylase;Deacetylation;Dependence;design;Development;Disease;Down-Regulation;Endosomes;Ensure;Exhibits;exosome;expectation;extracellular vesicles;Generations;Glutamine;Goals;high resolution imaging;Immune Evasion;Immune response;Immunotherapy;Impairment;insight;Laboratories;Lung;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Metabolic;Metabolism;metastatic process;migration;Monitor;mouse model;multidisciplinary;Multivesicular Body;Mus;Nature;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Organoids;Play;Process;Production;Proteins;Reagent;Regulation;Resistance;RNA;RNA-Binding Proteins;Role;Signal Transduction;SIRT1 gene;Sirtuins;spheroids;System;Testing;Therapeutic;three dimensional cell culture;trafficking;Transcript;tumor;tumor growth;tumor metabolism;tumor progression;vacuolar H+-ATPase;Work;Xenograft Model

PROJECT_TITLE: Metabolic regulation of exosome biogenesis as a determinant of cancer cell metastasis.

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cardiovascular;Cerebrovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Stroke

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Pericytes are a prominent cell type in the brain and heart, but their contribution to scar formation after ischemic injury is not well defined. In this proposal we plan to investigate how pericytes participate in fibrosis following stroke and myocardial infarction and which regulatory genes control this process. The proposed studies will identify mechanisms responsible for pericytes activation as targets for effective anti-fibrotic therapies.

PI_NAMEs: CARMICHAEL, STANLEY THOMAS (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Address;Adult;antifibrotic treatment;Area;Astrocytes;Behavior;Bioinformatics;Blood Vessels;Body System;Brain;brain pericytes;Candidate Disease Gene;Cardiac;Cardiac Myocytes;Cardiovascular system;cell type;Cells;Central Nervous System;Cicatrix;Collaborations;Collagen;Communication;Data;Deposition;Development;differential expression;Disease;Endothelial Cells;Equilibrium;experimental study;Extracellular Matrix Proteins;Fibroblasts;Fibrosis;gain of function;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Grant;Heart;Heterogeneity;Homeostasis;Immune;immune cell infiltrate;In Vitro;in vivo Model;Inflammatory;Inflammatory Infiltrate;Inflammatory Response;Injury;insight;Ischemia;ischemic injury;Ischemic Stroke;Knowledge;Label;Laboratories;Lead;Lesion;Literature;loss of function;Maps;Mediator;Mesenchymal;migration;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;Myocardial Infarction;Necrosis;Neurologist;neuron loss;Neurosciences;new growth;novel;Organ;Outcome;Paracrine Communication;Pathway interactions;Pattern;Pericytes;Population;Population Heterogeneity;population migration;post stroke;prevent;Process;Proliferating;Property;Reaction;Recovery;Recovery of Function;Regenerative capacity;Regulator Genes;repaired;response to injury;Role;Scientist;single-cell RNA sequencing;Site;Spinal cord injury;Spinal Cord Lesions;Stroke;Surface;System;Techniques;tissue repair;Tissues;tool;transcriptome;transcriptomics;Transgenic Mice;Up-Regulation;Viral;viral gene delivery;Work

PROJECT_TITLE: The role of pericytes in scar formation following stroke and myocardial infarction

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative  We have previously demonstrated the importance of molecular pathways that control cartilage development in regulating the abnormal mineralization of where tendon attaches to bone (enthesis) seen in the hereditary bone disease called X-linked hypophosphatemia (XLH). These studies will characterize how the interplay of the hormone 1,25 dihydroxyvitamin D, cartilage-regulating molecule Growth Differentiation Factor 5 (GDF5), and cartilage-regulating signaling pathways modulate the development of the abnormal enthesis mineralization observed in XLH. Improved knowledge of the molecular pathways that lead to this abnormal mineralization will allow for identification of therapeutic targets for the treatment of XLH and will also allow for better understanding of the maturation of the tendon-bone attachment site.  .

PI_NAMEs: LIU, EVA S. (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Ablation;achilles tendon;Address;Affect;Age;Agonist;Attenuated;autocrine;Blocking Antibodies;bone;Bone Diseases;Bone Morphogenetic Proteins;Cartilage;cartilage development;Cells;Chondrocytes;Clinical Research;Clinical Trials;Complication;CYP27B1 gene;Data;design;Development;Dihydroxycholecalciferols;Disabling;Disease;Enthesopathies;Erinaceidae;Exhibits;Familial hypophosphatemic bone disease;Future;Gene Expression;Genes;growth differentiation factor 5;Histologic;Hormonal;hormone regulation;Hormones;Human;human data;Hypertrophy;Hypophosphatemia;immunoreactivity;Impairment;improved;Individual;Inherited;Investigation;Knowledge;Lentivirus;Ligands;Mechanical Stress;Mediating;mineralization;Mobility decline;Molecular;motor impairment;mouse model;mRNA Expression;Mus;muscle stress;mutant mouse model;Mutation;novel;novel therapeutics;Osteomalacia;Pain;paracrine;patellar tendon;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Phenotype;Play;prevent;Prevention;Production;prospective;Proteoglycan;Regulation;response;restoration;Rickets;Role;scleraxis;Serum;Signal Pathway;Signal Transduction;Signaling Protein;Site;smoothened signaling pathway;Stains;tendon development;Tendon structure;therapeutic target;Time;Vitamin D;Vitamin D3 Receptor

PROJECT_TITLE: Development of enthesopathy in the mouse model of X-linked hypophosphatemia

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Relapse to cocaine addiction is a clinical problem and the use of rodent models of cocaine seeking informs the understanding of the brain regions involved in this behavior. The results of the proposed work will provide mechanistic information into the role of a previously overlooked region – the olfactory tubercle in the ventral striatum. This research is relevant to the missions of NIH and NIDA because it seeks to understand the brain mechanisms of psychoactive drug effects and may lead to new treatments to reduce relapse.

PI_NAMEs: MA, MINGHONG ;WESSON, DANIEL W (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;addiction;Anatomy;Behavior;Brain;Brain region;burden of illness;Catecholamines;Cell Count;Cell Nucleus;cell type;Cells;Clinical;Cocaine;Cocaine Dependence;cocaine relapse;cocaine seeking;cocaine self-administration;Corpus striatum structure;cost;Cues;Data;dopaminergic neuron;drug of abuse;Electrophysiology (science);Extinction;Fiber;frontal lobe;Globus Pallidus;Goals;in vivo;Individual;insight;Investigation;Mainstreaming;Mediating;Methods;Midbrain structure;Mission;Modeling;motivated behavior;National Institute of Drug Abuse;nerve supply;neural;neurobiological mechanism;Neurobiology;Neurons;Nucleus Accumbens;Olfactory Pathways;Olfactory tubercle;optogenetics;Output;Pathway interactions;Pharmaceutical Preparations;Photometry;Physiological;Physiology;Population;Positioning Attribute;Property;Psychological reinforcement;Psychotropic Drugs;Publishing;receptor;Regulation;reinforcer;Relapse;Research;reward circuitry;Rewards;Rodent;Rodent Model;Role;Self Administration;Sensory;Shapes;Site;Slice;Societies;Structure;Substance abuse problem;substance misuse;Synapses;System;Testing;Therapeutic Intervention;United States National Institutes of Health;Ventral Striatum;Ventral Tegmental Area;Work

PROJECT_TITLE: Circuitry and function of ventral striatum subregions

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) and related dementias (ADRD) are the leading U.S. health concern of the 21st century, and night shift work is an increasingly recognized risk factor for AD/ADRD. The proposed study is the first in a broader program of research that will characterize AD/ADRD-related cognitive function, brain structure, and brain bioenergetics in retired night shift workers compared to retired day workers, generating evidence on the potential “scarring” of shift work exposure on Alzheimer’s disease risk. Findings will inform future experimental approaches to identify behavioral and pharmacological interventions to prevent and attenuate the clinical course of AD/ADRD in a large portion of U.S workers.

PI_NAMEs: LEHRER, HENRY MATTHEW (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Adenosine Triphosphate;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid beta-Protein;Atrophic;Attenuated;Behavioral;Bioenergetics;Biological Markers;Brain;brain volume;career;career development;Chronic;Cicatrix;cingulate cortex;Circadian Dysregulation;Circadian Rhythms;Clinical;Cognitive;cognitive function;cognitive testing;cohort;Consumption;Cornus;Data;Data Collection;dementia burden;dementia risk;design;Deterioration;Development;Development Plans;Early identification;Education;Energy consumption;Energy Metabolism;Epidemiology;Episodic memory;Equation;Ethnic Origin;executive function;Exhibits;Exposure to;Future;Glucose;Goals;Health;Hippocampus;Hour;Impaired cognition;indexing;Individual;innovation;inorganic phosphate;interest;Intervention;Knowledge;Learning;Link;Long-Term Effects;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Magnetism;Measures;Mediating;Metabolic;Methods;Nerve Degeneration;Neurobiology;Neurocognitive;neurogenesis;neuroimaging;Neurons;older adult;Participant;Pathway interactions;Pattern;Peripheral;pharmacologic;Phosphocreatine;Phosphorus;Plasma;Play;poor sleep;Population;precision medicine;predictive marker;prevent;Prevention;primary outcome;programs;Public Health;Race;Recontacts;Recovery;rehabilitation strategy;Research;Research Personnel;retiree;Risk;Risk Reduction;Rodent;Role;Rotation;Sampling;Scientist;Sentinel;sex;shift work;skills;Sleep;Sleep disturbances;Societies;Spectrum Analysis;Structure;tau Proteins;Testing;Training;Training Programs;Work

PROJECT_TITLE: Characterizing Alzheimer's Risk in Retired Night Shift Workers: Cognitive Function, Brain Volume, and Brain Bioenergetics

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Project Narrative We are investigating interactions between two pairs of epigenetic regulators in the hemaotpoetic malignancy, acute myeloid leukemia (AML). Using a newly developed CRISPR-Cas12a-based screening approach, our preliminary data identified novel synergistic interactions between bromodomain containing protein 9 (BRD9) and Jumonji domain-containing protein 6 (JMJD6) as well as the lysine acetyltransferase 6 (KAT6) and JMJD6. In this proposal, we will determine the mechanism of interaction between these two pairs of epigenetic regulators and their role as novel dependencies in AML both in vitro and in mouse models and will evaluate their potential as therapeutic targets for AML.

PI_NAMEs: SHI, JUNWEI  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine;Acetyltransferase;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Arginine;Biological;Biological Assay;Bromodomain;Cancer cell line;Candidate Disease Gene;Cell Line;ChIP-seq;Chromatin;chromatin modification;chromatin remodeling;Chromosomal translocation;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;combinatorial;Complement;Complementary DNA;Complex;CRISPR/Cas technology;Data;Dependence;Enhancers;Epigenetic Process;epigenetic regulation;Essential Genes;Family;Genes;Genetic;Genetic Screening;Genetic Transcription;Genetically Engineered Mouse;Goals;Growth;Hematopoietic Neoplasms;histone acetyltransferase;Histones;Human Cell Line;improved;In Vitro;in vivo;inhibitor;innovation;insight;Knock-out;Knowledge;Lead;leukemia;Lysine;Maintenance;Malignant - descriptor;Malignant Neoplasms;Masks;Mediating;Methods;Modification;Molecular;molecular subtypes;Mouse Cell Line;mouse model;mutant;Myeloid Cells;Myeloid Progenitor Cells;neoplastic cell;new therapeutic target;novel;Oncogenic;overexpression;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Phenotype;Post-Translational Protein Processing;programs;Proliferating;protein complex;Proteins;Reader;RNA;Role;Scanning;screening;self-renewal;SMARCA4 gene;Stress;SWI/SNF Family Complex;Therapeutic;therapeutic target;Therapeutically Targetable;Transcription Coactivator;Transcription Regulation Pathway;transcriptome sequencing;transcriptomics;Treatment Efficacy

PROJECT_TITLE: Investigating novel synthetic lethal epigenetic interactions in Acute Myeloid Leukemia

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Delirium (acute confusion) is a common, morbid, and costly geriatric syndrome, with strong epidemiological associations with Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD). This clinical and translational project uses six unique datasets of older adults undergoing major elective surgery and in the community to advance our understanding of the potential shared pathophysiology underlying the delirium- AD/ADRD relationship. Specifically, we will determine whether genetic risk for AD/ADRD identifies individuals with a “vulnerable brain,” who may be predisposed to bad outcomes, including delirium, cognitive decline, and AD/ADRD, in the presence of an inflammatory insult (e.g., surgery or infection). Our findings will inform targeted strategies to identify older adults vulnerable to adverse brain-related outcomes under stress and high inflammation, thereby potentially leading to new interventions to prevent delirium and reduce AD/ADRD.

PI_NAMEs: VASUNILASHORN, SARINNAPHA  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acceleration;Acute;acute stress;Adult;Age;aged;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Apolipoprotein E;big biomedical data;biobank;Biological;biological adaptation to stress;Blood;Brain;C-reactive protein;Candidate Disease Gene;Catechol O-Methyltransferase;Clinical;clinical predictors;Code;Cognition;Cognitive;cognitive function;cohort;Communities;Confusion;cost;Creativeness;Data;Data Set;Delirium;Dementia;Development;DNA Library;Elderly;Encephalitis;Enrollment;Epidemiology;follow-up;Functional disorder;Funding;Gene Proteins;Genetic;genetic information;Genetic Materials;Genetic Risk;genetic risk factor;genome sequencing;genome-wide;genomic locus;Genotype;Goals;Health;Hospitals;human old age (65+);Impaired cognition;Individual;Infection;Inflammation;Inflammatory;inflammatory marker;Interleukin-6;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;Knowledge;Link;Measures;Medical Records;Microglia;Modeling;multiple datasets;Neurocognitive;neuroinflammation;Neurologic Dysfunctions;neuroprotection;novel;older adult;Operative Surgical Procedures;Outcome;Participant;Patients;Perioperative Care;Plasma;polygenic risk score;population based;post-operative cognitive dysfunction;postoperative delirium;Postoperative Period;Predisposing Factor;prevent;Prevention;programs;Quality of life;Research;Resources;Risk;Risk Factors;Sampling;Signal Transduction;Stress;Syndrome;systemic inflammatory response;Testing;Time;United Kingdom;Work

PROJECT_TITLE: Brain Vulnerability in Delirium and Alzheimer’s Disease and Related Dementias: Intersection of Polygenic Risk and Inflammation

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: WASHINGTON

ORG_NAME: CARNEGIE INSTITUTION OF WASHINGTON, D.C.

ORG_STATE: DC

PHR: Alternative RNA splicing is an important mechanism of gene regulation in all eukaryotes and both  evolutionarily conserved and divergent mechanisms are involved in different species. Acinus is  conserved in animals and plants and plays important roles in transcription and alternative  splicing, and Arabidopsis AtAcinus has distinct functions in regulating developmental transitions.  O-GlcNAcylation is essential to plants, but how O-GlcNAcylation exerts its roles remains unclear. A  detailed molecular dissection of AtAcinus and roles of O-GlcNAcylation in plants is proposed and  will advance our understanding of developmental regulation in plants and gene expression regulation  in general.

PI_NAMEs: XU, SHOULING  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Acinus organ component;Affinity Chromatography;Agriculture;Alternative Splicing;Amino Acids;Animals;Apoptosis;Arabidopsis;Arabidopsis Proteins;Biochemical;biological adaptation to stress;Biological Models;Biology;Cell Differentiation process;cell growth regulation;Chromatin;Complement;Complex;crosslink;crosslinking and immunoprecipitation sequencing;Cues;Data;Development;Dissection;Ensure;Eukaryota;Eukaryotic Cell;Event;experimental study;Flowers;Fractionation;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;genetic approach;Genetic Transcription;Genomic approach;Genomics;Germination;Goals;Health;Homologous Gene;hormonal signals;Human;in vivo;Introns;Label;Link;Maps;Mass Spectrum Analysis;Modification;Molecular;Mutagenesis;mutant;Names;novel strategies;Nutrient;O-GlcNAc transferase;Pathway interactions;Plant Gene Expression Regulation;plant growth/development;Plants;Play;Post-Translational Protein Processing;posttranscriptional;Productivity;programs;protein complex;Proteins;Proteomics;Regulation;Regulatory Pathway;Research;response;RNA;RNA Splicing;RNA-Protein Interaction;Role;Signal Transduction;Site;Specificity;Stress;sugar;synthetic protein;System;Technology;Testing;Transcriptional Regulation;transcriptome sequencing;Transgenic Organisms;Transgenic Plants

PROJECT_TITLE: Nutrient regulation of Alternative splicing and transcription by O-GlcNAcylation

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioids;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Deficits in reward processing (i.e. anhedonia, the lack of pleasure and motivation to seek rewards) is a cardinal symptom of addiction, chronic pain and mood disorders; which together represent a rapidly escalating public health crisis. We will elucidate how connectivity between two critical nodes in the reward system, the ventral pallidum and nucleus accumbens, drives hedonic valuation and consumption of rewards. This insight will be critical to ultimately develop effective circuit-based therapies to treat symptoms of dysfunctional reward processing across multiple chronic, relapsing neuropsychiatric disorders.

PI_NAMEs: CREED, MEAGHAN C (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Affective Symptoms;Anatomy;Anhedonia;Basal Ganglia;Behavior;Behavior monitoring;cholinergic;Chronic;Chronic Disease;chronic pain;Consumption;Deep Brain Stimulation;Detection;Dialysis procedure;Disease;Dopamine D1 Receptor;Dopamine D2 Receptor;Electrophysiology (science);endogenous opioids;Etiology;Fishes;Fluorescent in Situ Hybridization;Functional disorder;gamma-Aminobutyric Acid;Globus Pallidus;Goals;Health;hedonic;Impairment;in vivo;Infusion procedures;insight;interest;Interneurons;kappa opioid receptors;Maps;Measures;Mediating;Modeling;molecular imaging;Mood Disorders;Motivation;neural;Neural Pathways;neurochemistry;Neurons;neuropsychiatric disorder;novel;Nucleus Accumbens;Opioid agonist;optogenetics;Output;Pain Disorder;patch clamp;Pathway interactions;Peptides;Play;pleasure;Population;postsynaptic;Public Health;Reaction;Relapse;response;reward dysfunction;reward processing;Rewards;Role;Source;Structure;Substance Use Disorder;symptom treatment;Symptoms;Synapses;System;Testing;tool;Transgenic Mice;translational approach;transmission process;Viral

PROJECT_TITLE: Dissecting the role of ventral pallidal projections to nucleus accumbens in reward processing


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Project Narrative  Hepatocellular carcinoma (HCC) is a major human malignancy and largely incurable. In this project, we will define the molecular mechanisms by which focal adhesion kinase (FAK) promotes HCC development, FAK is regulated, and HCC cells acquire resistance to FAK inhibition. The results from this study will provide an important mechanistic basis for treating HCC by targeting FAK.

PI_NAMEs: QIU, WEI  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Animals;beta catenin;Cessation of life;Data;Development;Focal Adhesion Kinase 1;Genetic;Glucose;Glycolysis;Grant;Growth;Hepatocarcinogenesis;Hepatocyte;Hexokinase A;Human;improved;Intervention;kinase inhibitor;Liver;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;Molecular;Mus;novel;overexpression;Patients;pharmacologic;Phosphorylation;Phosphotransferases;Play;Primary carcinoma of the liver cells;Resistance;response;Role;Specimen;SPINK1 gene;targeted treatment;Testing;Therapeutic Intervention;therapeutically effective;tumor growth;United States

PROJECT_TITLE: Molecular mechanisms of focal adhesion kinase in promoting hepatocarcinogenesis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative This study identifies a deubiquitination module in controlling Treg adaptation to the harsh tumor microenvironment and provides a rational for simultaneous targeting USP21 and USP22 in antitumor immune therapy.

PI_NAMEs: FANG, DEYU  (contact);ZHANG, BIN

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Ablation;Acidity;Amino Acids;anti-tumor immune response;Antitumor Response;cancer cell;Cancer Patient;cancer therapy;Carbon Dioxide;checkpoint receptors;Clinical;Cues;cytokine;Data;Deubiquitination;Development;effector T cell;fitness;forkhead protein;FOXP3 gene;Glucose;Growth Factor;Human;Hypoxia;immune checkpoint blockade;Immune system;immunogenicity;Immunosuppression;Immunotherapy;improved;Infiltration;Malignant neoplasm of lung;Mediating;Metabolic;Modeling;Molecular;Mus;neoplasm immunotherapy;Neoplasm Metastasis;neoplastic cell;novel;Peptide Hydrolases;programs;Publications;Regulatory T-Lymphocyte;Role;Stress;success;synergism;Testing;Therapeutic;transcription factor;Treatment Efficacy;tumor;Tumor Escape;Tumor Immunity;tumor microenvironment;Ubiquitin;ubiquitin isopeptidase;Up-Regulation

PROJECT_TITLE: A deubiquitination module controls Treg adaptation to tumor microenvironment

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Hematology;Patient Safety

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project narrative: This proposal is significant to public health because poor communication between patients and health care providers can lead to adverse outcomes including increased emergency department (ED) visits, hospitalization, decreased adherence and death. This project aims to improve this communication by creating and testing guidance for creating high quality patient education materials. Increased adherence to medications and high-quality patient education can decrease costs, hospitalizations, and improve quality of life.

PI_NAMEs: JONES, AUBREY ELISE (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Adherence;Adopted;Adverse drug event;Adverse event;adverse outcome;Anticoagulant therapy;Anticoagulants;Anticoagulation;Award;Caring;Cessation of life;Clinical;Communication;cost;Data;design;Development;Drug Interactions;Education;education evaluation;Educational Intervention;Educational Materials;Educational Models;Educational Technology;Elements;Emergency department visit;evidence base;evidence based guidelines;Evidence based practice;feasibility testing;Goals;Guidelines;Health;health care settings;Health Personnel;Hemorrhage;high risk;hospital readmission;Hospitalization;improved;Instruction;Interdisciplinary Study;International;Intervention;iterative design;K-Series Research Career Programs;Knowledge;Leadership;Learning;learning strategy;medication compliance;Mentors;Methodology;Methods;mortality;Online Systems;Outcome;Output;Patient Education;patient safety;patient-clinician communication;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pilot Projects;pilot test;Procedures;Process;Provider;provider communication;Public Health;Quality of life;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Personnel;Safety;satisfaction;shared decision making;skills;statistics;support tools;Techniques;Testing;theories;tool;Training;Training Programs;user centered design;user-friendly

PROJECT_TITLE: A theory-based practice guide for creating patient education

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Inherited familial cardiomyopathies affecting 1 out of 500 people result from missense mutations in various cardiac muscle proteins, with mutations in beta-cardiac myosin and myosin binding protein C accounting for the vast majority of this disease. Current therapies for cardiomyopathies are limited to symptomatic relief, in large part because it is not understood how these mutations affect the ability of the heart to contract at its most fundamental level. Our research will significantly enhance our understanding of the effects of disease causing mutations on the fundamental contractile properties of the heart.

PI_NAMEs: SPUDICH, JAMES  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Accounting;Actins;Actomyosin Adenosinetriphosphatase;Affect;alpha helix;Animal Model;Back;beta-Myosin;Binding;Biochemical;Biological Assay;Biomechanics;Calcium Binding;Cardiac;cardiac muscle disease;Cardiac Myosins;Cardiac Output;Cardiomyopathies;Cardiovascular Diseases;Cell Physiology;Clinical;Collaborations;Complex;Contracts;crosslink;Cryoelectron Microscopy;Data;Defect;Disease;disease-causing mutation;Distal;drug discovery;Drug Targeting;Electron Microscopy;Energy consumption;experimental study;Familial Hypertrophic Cardiomyopathy;Family;Fluorescence Resonance Energy Transfer;Grant;Heart;Heart failure;Human;Hypertrophic Cardiomyopathy;In Vitro;Individual;Induced Mutation;Inherited;inherited cardiomyopathy;interfacial;Length;Link;Mass Spectrum Analysis;Measurement;Measures;Minnesota;Missense Mutation;Molecular;Molecular Conformation;Molecular Motors;Motor;Movement;Muscle;Muscle Proteins;mutant;Mutation;Myocardium;Myosin ATPase;Myosin Regulatory Light Chains;myosin-binding protein C;nanosecond;Negative Staining;novel;Output;Persons;Phosphorylation;Physiological;Play;Point Mutation;Property;protein B;Proteins;reconstitution;Regulation;Reporting;Research;Resolution;Role;Sarcomeres;Shapes;Site;small molecule;Structure;Sudden Death;System;Tail;Testing;Therapeutic Intervention;Thick Filament;Time;time use;tool;Universities;Ventricular;Work

PROJECT_TITLE: Myosin Movement In Vitro - Molecular Characterization

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Mitochondria are cellular organelles that control energy production and oxidative stress. Defects in mitochondrial functions underlie numerous metabolic disorders including obesity and type 2 diabetes. Here our proposal investigates two novel and opposing signaling mechanisms that regulate mitochondrial remodeling, which we hypothesize play critical roles during development and tissue homeostasis.

PI_NAMEs: LEE, NAM Y (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Adult;Affect;angiogenesis;Apoptosis;Biogenesis;Biological Models;Blood Vessels;cell behavior;Cell Physiology;Cellular Metabolic Process;Complex;Defect;Development;Embryonic Development;Gene Expression Regulation;Homeostasis;Knowledge;MAP3K7 gene;Metabolic;Metabolic Diseases;Mitochondria;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organelles;Oxidative Stress;Physiology;Play;Production;programs;Proliferating;Regulation;Research;Respiration;Role;Shapes;Signal Transduction;theories;Tissues;Transforming Growth Factor beta;virtual

PROJECT_TITLE: TGF-beta signaling in mitochondrial dynamics

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Diabetes;Digestive Diseases;Genetics;Heart Disease;Hematology;Infectious Diseases;Nutrition;Obesity;Vector-Borne Diseases

PHR: PROJECT NARRATIVE Diabetic patients are at serious risk of dying from cardiovascular causes (e.g., atherosclerosis) and the main risk factors for this are obesity and ongoing insulin resistance. It has recently been established that the rates of obesity, insulin resistance, and atherosclerosis are greatly reduced in areas of the world with chronic helminth infections. The purpose of this study is to determine the mechanisms behind helminth-induced alterations to the metabolism and immunologic function of macrophages, as well as how these modulations determine protection from the development of atherosclerosis and insulin resistance in a mouse model of high-fat diet induced atherosclerosis and obesity; with a long-term goal of identifying targets for new treatments of diabetes and atherosclerosis.

PI_NAMEs: AMIEL, EYAL ;FAIRFAX, KEKE CELESTE (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Address;amino acid metabolism;Anti-Inflammatory Agents;Antiatherogenic;Antigens;Apolipoprotein E;Area;Asthma;Atherosclerosis;biological sex;Bone Marrow;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cells;Cholesterol;Cholesterol Homeostasis;Chronic;chronic inflammatory disease;cytokine;Data;Dependence;Development;Diabetes Mellitus;diabetic;diabetic patient;Differentiation Antigens;Disease;Estrogens;Female;Formulation;Genetic;Genetic Transcription;Genomics;Glucose Intolerance;Goals;Gonadal Steroid Hormones;helminth infection;Helminths;hematopoietic differentiation;Hepatic;High Fat Diet;immune function;Immunologics;immunoregulation;Infection;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;innovation;Insulin;Insulin Resistance;insulin sensitivity;Interleukin-4;Link;Lipids;Literature;Macrophage;Macrophage Activation;male;Maps;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;Modeling;Modification;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Myelogenous;Myeloid Progenitor Cells;Nematoda;non-diabetic;novel;novel strategies;Obesity;Oxygen Consumption;Pathology;Pathway interactions;Patients;Phenotype;Phospholipid Metabolism;Phospholipids;Population;Principal Component Analysis;progenitor;Progesterone;protective effect;Recording of previous events;Research;Resolution;respiratory;Risk;Risk Factors;Role;Schistosoma;Schistosoma mansoni;stem cell niche;success;Testing;Testosterone;therapy development;Transcription Alteration;transcriptome;transcriptomics

PROJECT_TITLE: Durable Schistosome induced metabolic alterations to the myeloid lineage

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Despite the success of perinatal and postnatal HIV transmission prevention services, many children born to mothers with HIV are not thriving. The proposed research will explore the interaction between HIV and child neurodevelopment to create a risk assessment tool predicting worse neurodevelopmental outcomes in order to target appropriate interventions to those in need. Thus, the proposed research is relevant to the NIH’s mission, as it develops fundamental knowledge to enhance health and reduce the burdens of human disability.

PI_NAMEs: MCHENRY, MEGAN SONG (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: 2 year old;Acquired Immunodeficiency Syndrome;Affect;Africa South of the Sahara;African;Age Months;Anti-Retroviral Agents;antiretroviral therapy;Assessment tool;Behavior;Biological;Biological Factors;Biological Markers;Birth;Birth History;Breast Feeding;Child;Child Behavior Checklist;Clinical;Cognition;cohort;Cohort Studies;Communicable Diseases;Country;Data;Databases;Development;Diarrhea;disability;Education;Enrollment;Epidemiology;Etiology;evidence base;Exposure to;Face;Fetal Alcohol Exposure;Future;Goals;Health;health care availability;HIV;Home environment;Human;improved;Infant;Inflammatory;International;Intervention;Iron deficiency anemia;Kenya;Knowledge;Language;Lead levels;Life;Longitudinal cohort;Longitudinal Studies;Malaria;Malnutrition;Measles;Measures;Meningitis;Mental Health;Mission;Modeling;Monitor;Morbidity - disease rate;Mothers;Motor;neurodevelopment;Newborn Infant;Outcome;Outcome Study;Participant;peer;Perinatal;Pharmaceutical Preparations;pharmacovigilance;Pneumonia;Population;postnatal;Poverty;Predictive Factor;predictive tools;Pregnancy;Pregnant Women;prevention service;prospective;Provider;psychosocial;Psychosocial Factor;Punishment;Quality of life;Recording of previous events;Research;Risk;Risk Assessment;Risk Factors;Sanitation;social;social factors;sociodemographic factors;sociodemographics;Stress;success;Surveillance Program;Toddler;tool;transmission process;Tuberculosis;United States National Institutes of Health;violence exposure;Water;Woman;Work

PROJECT_TITLE: Predicting neurodevelopmental risk in children born to mothers living with HIV in Kenya


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE Malignant gliomas are among the most deadly human cancers. Enhancing Delta-24-RGDOX anti-glioma effects represents a major step forward in improving immunotherapy for cancer and in broadening the spectrum of treatments for patients with this deadly disease for whom there are currently only minimally effective therapies.

PI_NAMEs: FUEYO, JUAN  (contact);GOMEZ-MANZANO, CANDELARIA

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: adenoviral mediated;Adenoviruses;Adjuvant;Agonist;anti-cancer;anti-tumor immune response;Antineoplastic Agents;Aryl Hydrocarbon Receptor;Attenuated;Biological;Biological Products;Brain Neoplasms;cancer immunotherapy;cancer therapy;Catabolism;Categories;CD8-Positive T-Lymphocytes;Cell Cycle;Cells;Characteristics;Clinical;Clinical Data;Clinical Trials;Combined Modality Therapy;cytotoxic;Data;deprivation;Development;Disease;DNA biosynthesis;Dose;Drug Industry;effective therapy;Environment;Essential Amino Acids;first-in-human;Functional disorder;Future;Glioblastoma;Glioma;Goals;Human;Immune;immune activation;Immune response;Immune system;Immune Tolerance;Immunocompetent;immunogenic cell death;Immunosuppression;immunotherapeutic virotherapy;Immunotherapy;improved;In Situ;indoleamine;Infection;inhibitor;Injections;interest;Interleukin-2;Kynurenine;Laboratories;Lymphocyte;Magnetic Resonance Imaging;Malignant Glioma;Malignant Neoplasms;Mediating;Mesocricetus auratus;Metabolic;Modeling;Modification;mouse model;Mus;Names;neoplastic cell;novel;oncolysis;Oncolytic;oncolytic adenovirus;oncolytic virotherapy;Oncolytic viruses;Operative Surgical Procedures;Pathway interactions;patient subsets;Patients;permissiveness;Phase;Phase I Clinical Trials;Population;Positioning Attribute;pre-clinical;prevent;Production;Publishing;recruit;Recurrence;Regulatory T-Lymphocyte;response;Safety;Shapes;Site;Solid Neoplasm;Specimen;standard care;Survival Rate;T cell anergy;T cell infiltration;T-Cell Activation;T-cell receptor repertoire;T-Lymphocyte;Testing;Therapeutic;Time;TNFSF4 gene;Translating;Tryptophan;tumor;tumor microenvironment;Vaccination;Viral;Virotherapy;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Glioma therapy with oncolytic adenoviruses and immunometabolic adjuvants

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Human Genome;Rare Diseases

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE Current tools for inserting genes have drawbacks such as immune response, limited gene size, and uncontrolled insertion which may lead to cancer. This project aims to develop a new tool capable of inserting therapeutic genes of flexible size to a safe location in the human genome. A treatment for Hemophilia B will be tested to demonstrate a therapeutically relevant application of this new technology.

PI_NAMEs: OWENS, JESSE BRUCE (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Address;Bacteria;Bacteriophages;Biological Assay;Cell division;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Coupled;Data;detection platform;Development;Directed Molecular Evolution;Disease;DNA;DNA Binding;DNA Integration;Drops;Enzymes;Escherichia coli;Evolution;experimental study;Factor IX;flexibility;gene correction;Gene Delivery;gene replacement;Gene Targeting;gene therapy;Genes;Genetic Diseases;Genetic Transcription;Genome;genome editing;genome-wide analysis;Genomic Segment;Genomics;Goals;Hemophilia B;Hepatocyte;Human;Human Cell Line;Human Genome;Immune response;improved;Individual;innovation;Insertional Mutagenesis;Integrase;Integration Host Factors;Interphase Cell;Intervention;Laboratories;Liver;Location;Malignant Neoplasms;Microbubbles;Modeling;mouse model;Mus;Mutate;Mutation;new technology;novel;nuclease;Pathway interactions;Patients;plasmid DNA;pre-clinical research;Proteins;Publishing;repaired;Reporter;Research;Research Personnel;Risk;Serine;Site;Specificity;System;Techniques;Technology;technology platform;Testing;Therapeutic;therapeutic gene;therapeutic transgene;therapy outcome;Time;Tissues;tool;transgene expression;Transgenes;ultrasound;Variant;vector;Virus

PROJECT_TITLE: Directed evolution of a sequence-specific targeting technology for therapeutic gene delivery to the human genome.

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Metabolic Imaging of Targeted Therapies in Cancer PROJECT NARRATIVE The proposed research is relevant to public health because additional criteria are needed besides tumor volume to accurately determine treatment response when cancer is treated using new cytostatic drugs (i.e., drugs that affect cellular functions without major effect on tumor volume). This project proposes investigating the metabolism of a neoplasm of the immune system called diffuse large B-cell lymphoma or DLBCL using imaging methods that are fast (i.e., results can be reported in a few hours) and noninvasive (i.e., do not need biopsies or radiation). This project is relevant to NIH's mission because it aims to: (1) assess metabolic changes produced by cytostatic drugs in DLBCL; (2) evaluate if early changes in metabolites predict the final response to therapy regarding these metabolites as predictive biomarkers of response; and (3) determine the accuracy of the metabolic biomarkers to help evaluate the treatment response of DLBCL to cytostatic drugs.

PI_NAMEs: NATH, KAVINDRA  (contact);WASIK, MARIUSZ A.

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Affect;Aftercare;Biological;Biological Markers;biomarker selection;biomarker validation;Biopsy;cancer cell;Cancer Model;Cancer Patient;cancer therapy;cancer type;candidate identification;candidate marker;cell growth;Cell Line;Cell Physiology;Cell Transplantation;Cells;Cellular Metabolic Process;Chemicals;Citric Acid Cycle;Clinic;Clinical;Clinical Trials;Cytostatics;Data;Detection;Diagnosis;Disease;early detection biomarkers;Enzymes;Evaluation;Exhibits;Fatty Acids;fluorodeoxyglucose positron emission tomography;FRAP1 gene;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;genome-wide;Genomics;Glycolysis;Goals;Hexokinase 2;Hour;Hyperactivity;Hypoxia;Image;imaging biomarker;imaging detection;imaging modality;Imaging Techniques;Immune system;In Vitro;in vivo;in vivo Model;indexing;inhibitor;inhibitor therapy;insight;kinase inhibitor;Knowledge;Lactic acid;large cell Diffuse non-Hodgkin's lymphoma;Lymphoma;Lymphoma cell;Malignant Neoplasms;Measurement;Measures;Metabolic;metabolic abnormality assessment;metabolic imaging;Metabolic Pathway;Metabolism;metabolomics;Methods;Mission;Modeling;Monitor;mouse model;mTOR inhibition;mTOR Inhibitor;Mus;Neoplasms;neoplastic cell;Non-Invasive Detection;non-invasive imaging;novel;Outcome;Pathway interactions;patient response;Patients;Pentosephosphate Pathway;personalized medicine;Pharmaceutical Preparations;phosphoproteomics;Phosphorylation;Phosphotransferases;Physiologic pulse;Positron-Emission Tomography;potential biomarker;pre-clinical;preclinical study;Preclinical Testing;predicting response;predictive marker;protein expression;Protein-Serine-Threonine Kinases;Proteins;Proteome;Proteomics;Public Health;Radiation;Reporting;Research;research clinical testing;response;response biomarker;SDZ RAD;Serine;Signal Pathway;Signal Transduction;Sirolimus;small molecule;Staging;Standardization;Sterols;System;targeted treatment;Testing;Therapeutic Effect;Therapeutic Intervention;transcriptome sequencing;translational potential;treatment response;tumor;Tumor Markers;tumor metabolism;Tumor Volume;United States National Institutes of Health;Work;Xenograft Model;Xenograft procedure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-L(02)M]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative The long-term goal of my laboratory is to elucidate the mechanisms that determine the developmental arrest in rhabdomyosarcoma (RMS) and leverage these findings to develop novel, directed therapies. The objective of this proposal is to leverage our robust genetically engineered RMS mouse models coupled with in vitro assays to define the role of PTEN, PAX7 and DBX1 in RMS. This work will also contribute to other cancers given DBX1 overexpression is found in many brain cancers and PTEN deletions and mutations are found in a significant portion of the cancers.

PI_NAMEs: HATLEY, MARK EDWARD (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Acute Promyelocytic Leukemia;Affinity Chromatography;aggressive therapy;AKT1 gene;Attenuated;Automobile Driving;Binding;Binding Sites;Biological Assay;Biology;Cell Nucleus;Cells;Child;Childhood;Childhood Brain Neoplasm;Childhood Rhabdomyosarcoma;chromatin immunoprecipitation;Clinical Trials;Coupled;design;Development;differentiation in vitro;Differentiation Therapy;Dissection;DNA sequencing;Embryonal Rhabdomyosarcoma;Ependymoma;experimental study;FOXO1A gene;FRAP1 gene;gain of function;Gene Expression Profile;Gene Fusion;Genes;Genetic Engineering;Genetic Transcription;Genetically Engineered Mouse;Goals;high risk;Human;Hypermethylation;In Vitro;in vitro Assay;in vivo;insight;Isotretinoin;Knowledge;Laboratories;loss of function;Luciferases;Malignant neoplasm of brain;Malignant Neoplasms;Mass Spectrum Analysis;Mediator;Medulloblastoma;MM form creatine kinase;Modeling;Molecular;mouse model;Mus;Muscle Development;mutant;Mutation;Myoblasts;Neuroblastoma;Neurons;novel;novel therapeutics;Nucleic Acid Regulatory Sequences;overexpression;Pathway interactions;PAX3 gene;PAX7 gene;Penetrance;Pharmacotherapy;Phenotype;PIK3CG gene;progenitor;promoter;Proteins;Proto-Oncogene Proteins c-akt;PTEN gene;Quantitative Reverse Transcriptase PCR;Regulation;Reporter;Rhabdomyosarcoma;Role;Signal Transduction;Skeletal Muscle;Soft tissue sarcoma;Testing;Therapeutic;Transcription Repressor;Transgenic Mice;Tretinoin;tumor;Work

PROJECT_TITLE: Mediators Of Arrested Differentiation In Pediatric Rhabdomyosarcoma


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Health Services;Lung;Lung Cancer;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The objective of this research is to transform tobacco control treatment delivery in child healthcare offices by testing the effectiveness of an innovative EHR systems platform (iEHR) with and without the additional support of a community health navigator. The newly developed iEHR will facilitate universal screening for all household members who smoke tobacco or are a dual user of tobacco and e-cigarettes, and provide default tobacco cessation assistance to parents by generating nicotine replacement therapy prescriptions and referrals to free resources (quitlines). Data on the cost-effectiveness of these approaches will help decision makers choose which intervention to implement in their organizations.

PI_NAMEs: FIKS, ALEXANDER GABRIEL;WINICKOFF, JONATHAN P (contact)

PROGRAM_OFFICER_NAME: PRUTZMAN, YVONNE M

PROJECT_TERMS: Accounting;Address;Adoption;Adult;Affect;arm;Cancer Burden;Cancer Patient;Carbon Monoxide;Cessation of life;Child;Child health care;Childhood;Community Health;compare effectiveness;comparison intervention;Contracts;cost;cost effective;cost effectiveness;Cotinine;Counseling;Data;design;Developmental Delay Disorders;Disease;Documentation;Early Diagnosis;Effectiveness;effectiveness testing;Electronic cigarette;electronic health record system;Electronics;Enrollment;Ensure;evidence base;eVisit;Exposure to;Family;Fire - disasters;follow-up;free behavior;Funding;Future;Goals;Health;Health Benefit;health care delivery;health care settings;Health Services Accessibility;Health system;Home;Home visitation;Household;household tobacco use;implementation framework;implementation intervention;improved;incremental cost;innovation;Insurance Coverage;Intervention;Interview;Life Expectancy;Link;Malignant Neoplasms;Medicaid;medically underserved;member;Minority;Morbidity - disease rate;mortality;nicotine replacement;nicotine use;Outcome;Parents;pediatrician;Persons;Population;Pregnancy Outcome;Prevention;Quality of life;quitline;Randomized;Randomized, Controlled Trials;Research;Resources;Risk;Schools;screening;service delivery;Services;Smoke;Smoke-free home;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;suburb;success;Surveys;survivorship;System;Telephone;Testing;thirdhand smoke;three-arm study;Time;Tobacco;tobacco cessation intervention;tobacco control;Tobacco Dependence;Tobacco smoke;tobacco smoke exposure;Tobacco use;Tobacco Use Cessation;tobacco user;tobacco-free;treatment arm;treatment as usual;United States;Visit;Work

PROJECT_TITLE: Electronic Pediatric Office Systems to Support Treatment for Parental Tobacco Use

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Child Abuse and Neglect Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Health Services;Lung;Lung Cancer;Pediatric;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Violence Research

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Evidence-based interventions to create smoke-free homes can reduce secondhand smoke (SHS) exposure among young children and thus decrease lifetime risk of cancer. The purpose of this project is to integrate two effective prevention programs, one focused on SHS and another focused on child maltreatment that is widely disseminated to families with young children involved with the child protection system (a high-risk group for SHS). A Hybrid Trial 1 of this integrated intervention, “Smoke-Free SafeCare,” will aid in identifying ways to disseminate effective SHS interventions to high-risk groups, an important strategy for targeting tobacco- related cancer disparities.

PI_NAMEs: KEGLER, MICHELLE C;SELF-BROWN, SHANNON RENEE (contact)

PROGRAM_OFFICER_NAME: MAYER, MARGARET ELIZABETH

PROJECT_TERMS: Accreditation;Address;Adoption;Age;Air;Attention;brief intervention;cancer health disparity;cancer risk;Certification;Cessation of life;Child;Child Abuse and Neglect;Child Health;child protection;child protective service;Child Rearing;Child Welfare;Consent;cost;design;Educational Curriculum;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;environmental tobacco smoke;environmental tobacco smoke exposure;Evidence based intervention;Evidence based program;experience;Family;Family Research;Health;high risk;high risk population;Home;Household;hybrid type 1 trial;Hybrids;implementation process;improved;inclusion criteria;Intervention;intervention delivery;life span;lifetime risk;Link;low socioeconomic status;Maintenance;Malignant Neoplasms;maltreatment;Measures;Methods;Monitor;Mothers;Nicotine;Outcome;parental involvement;parenting intervention;Parents;Participant;Patient Self-Report;Persons;poor health outcome;Population;Poverty;premature;Prevention program;primary outcome;Process;Process Measure;program costs;programs;Provider;Public Health;Randomized;randomized trial;recruit;Reporting;Research;Risk;Risk Factors;Safety;Smoke;Smoke-free home;Smoker;Smoking;Smoking Behavior;Source;Standardization;System;Testing;Time;Tobacco-Related Carcinoma;Training;trend;United States;Victimization

PROJECT_TITLE: Establishing smoke-free homes with families involved in child protective services: An effectiveness-implementation trial of an integrated program

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Psychiatric and neurological diseases and disorders have a tremendous impact on society. Despite improved diagnosis and treatment, further advancement is significantly hindered by a lack of understanding how alterations in neural circuit function leads to the development and expression of disease states. The research directions outlined in this proposal will characterize the function of key neural circuits that are involved in psychiatric disease such as substance abuse disorders. We aim to study these neural circuit elements in order to identify potentially novel therapeutic targets for the treatment neuropsychiatric disorders.

PI_NAMEs: STUBER, GARRET D (contact)

PROJECT_TERMS: Adaptive Behaviors;addiction;Animals;Association Learning;awake;Award;Behavior;Behavioral;Brain;Brain region;calcium indicator;cell assembly;Cell Nucleus;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;conditioning;Cues;Data;Data Set;Decision Making;Dependence;design;Development;Diagnosis;Disease;Drug Addiction;Drug usage;Elements;Emotions;Estradiol;experimental study;Female;Funding;Gene Expression;Genes;Genetic;Goals;Habenula;hippocampal pyramidal neuron;holographic stimulation;Hormonal;hormonal signals;Hypothalamic structure;Image;improved;incentive salience;instrumentation;interest;Knock-out;Lateral;Learning;lens;Link;maladaptive behavior;male;Mediating;Mental disorders;Methods;Molecular;Molecular Genetics;molecular marker;motivated behavior;Mus;Nervous System Disorder;neural;neural circuit;neural patterning;Neurobiology;Neurons;neuropsychiatric disorder;neuropsychiatry;new therapeutic target;next generation;Opsin;Optics;optogenetics;Output;Pain;Pattern;Pharmaceutical Preparations;Physiological;Play;Population;Procedures;Process;Property;Research;Rewards;Role;Self Administration;Sensory;Signal Transduction;single-cell RNA sequencing;Societies;Steroids;Stimulus;Substance abuse problem;Technology;Testing;Testosterone;Time;two photon microscopy;two-photon;Universities;Ventral Tegmental Area;Viral;Virus;Washington;Work

PROJECT_TITLE: Neural circuit elements that orchestrate cue-reward associations

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative This project focuses on understanding circuit dynamics in the prefrontal cortex that mediate mnemonic chunking, a critical strategy for improving working memory performance in advanced cognition. Specifically, we will assess how mnemonic information is bound together in the dynamics of frontal and striatal circuits, and whether these processes can be enhanced with targeted circuit modulation. Our results could provide insights into core deficits in cognitive disorders, such as schizophrenia, and open the door for novel approaches that enhance cognitive function in the setting of working memory deficits.

PI_NAMEs: RICH, ERIN L (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Affect;Animal Model;Area;Artificial Intelligence;Basal Ganglia;Behavior;behavior test;Binding;biological systems;Bite;Brain;Code;Cognition;Cognition Disorders;Cognitive;cognitive ability;Cognitive deficits;cognitive enhancement;cognitive function;cognitive task;Complex;Computer Models;Corpus striatum structure;cost;Coupling;Creativeness;Data;density;Disease;experimental study;Expert Systems;flexibility;Frequencies;Functional disorder;Goals;Grouping;Human;Impairment;improved;information organization;innovation;insight;Intervention;Laboratories;language comprehension;Learning;Location;Macaca;Macaca mulatta;Measures;Mediating;member;Memory;Memory impairment;Mental disorders;Methods;microstimulation;Mind;Monkeys;Motor;neural;neuromechanism;Neurons;neurophysiology;neuroregulation;nonhuman primate;novel;novel strategies;Patients;Performance;Periodicity;Play;Population;Prefrontal Cortex;Primates;Problem Solving;Process;Psychology;Recurrence;Research;Resources;Role;Schizophrenia;self organization;Shapes;Short-Term Memory;Shorthand;Signal Transduction;Site;Social Security Number;Stimulus;Structure;Synapses;System;Systematic Bias;Telephone;Testing;Time;tool;Visual;Work

PROJECT_TITLE: Circuit mechanisms of self-organized cognitive strategies

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative This project aims to further define areas of information overload within electronic health records. Also, the study aims to test the efficacy of an information visualization dashboard on decision-making using a randomized-controlled trial. Finally, the research aims to create visualization implementation and usability best-practices.

PI_NAMEs: KHAIRAT, SAIF  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Academic Medical Centers;Address;Affect;Area;Clinic;Clinical Data;Cognitive;Complex;Computer Systems;Consumption;Control Groups;Critical Illness;dashboard;Data;Data Analyses;data dashboard;Decision Making;design;Diagnostic;efficacy evaluation;efficacy testing;Electronic Health Record;electronic health record system;Environment;experience;Eye;Fatigue;Frequencies;Goals;group intervention;Guidelines;heterogenous data;Hour;improved;indexing;Individual;information processing;Institution;Intensive Care Units;Interview;Intuition;Knowledge;Laboratories;Leadership;Measures;Medical center;Medical Errors;Methods;Miosis disorder;Monitor;Mus;novel;Nurse Practitioners;Outcome;patient safety;Patients;Perception;Performance;Physician Assistants;Physicians;Process;Provider;Quality of Care;Questionnaires;randomized trial;Randomized, Controlled Trials;recruit;Research;Research Design;response;Risk;sample fixation;satisfaction;Science;Severities;simulation;Site;Surveys;Time;tool;trial comparing;United States National Aeronautics and Space Administration;Universities;usability;Visit;Visual;visual tracking;Visualization;Visualization software;Workload

PROJECT_TITLE: Improving Providers’ Decision-Making and Reducing Information Overload Using Information Visualization in Electronic Health Records

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Narrative - Photonics-based Fluorescence Imaging for Research, Diagnostics and Pathology  Fluorescence detection is widely used in the biosciences. The instruments typically consist of many optical components. These spectrofluorometers and microscopes are complex and expensive because they are based on classical 100 year old optical technologies. We will create new imaging devices to eliminate almost all the complex optics. Multi-layer substrates will be fabricated which collects the emission and is directly coupled to a CMOS imaging detector. which. The CMOS imaging arrays inexpensive and robust, are used in consumer products and are becoming the dominant array detector in fluorescence microscopes. Collaborations are planned to use this device for virus counting assays, detection of weak binding in high-throughput screening and large field- of-view imaging of pathology slides.

PI_NAMEs: LAKOWICZ, JOSEPH R. (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 2019-nCoV;Area;Binding;Biological Assay;Biological Sciences;brain tissue;Cell membrane;Cells;cellular imaging;Cellular Phone;Centenarian;clinical application;Collaborations;Complex;consumer product;Coupled;Detection;detector;Devices;Diagnostic;Dimensions;drug discovery;Electronics;Fiber Optics;Flow Cytometry;Fluorescence;fluorescence imaging;fluorescence microscope;Fluorescence Microscopy;fluorophore;Generations;genetic testing;Goals;high throughput screening;HIV;Image;imaging detector;Imaging Device;Immunoassay;in vivo;instrument;lens;Light;Measurement;medical schools;Medicine;Microscope;multi-photon;Optics;Pathology;pathology imaging;Pharmaceutical Preparations;photonics;Photons;plasmonics;point-of-care diagnostics;Positioning Attribute;Property;Research;senior faculty;Slide;Specimen;Structure;Technology;Transistors;Virion;Virus;whole slide imaging

PROJECT_TITLE: Photonics-based Fluorescence Imaging for Research, Diagnostics, and Pathology


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: NARRATIVE The relative contributions of adaptive and non-adaptive processes in shaping within and between patterns of sequence variation in natural populations has remained a primary question of interest since the founding of population genetics a century ago. While great advances have been made, a major limiting factor remains the inability to jointly infer the suite of neutral parameters necessary to construct an appropriate null model. Here, I propose a computational approach to achieve this joint inference in organisms characterized both by Wright-Fisher and non-Wright-Fisher patterns of reproduction - an approach which will thus be relevant for commonly studied hosts (e.g., humans) as well as pathogens (e.g., viruses).

PI_NAMEs: JENSEN, JEFFREY D (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: On differentiating selective and neutral evolutionary processes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: The overarching goal of the Coordinating Center at the University of Wisconsin Carbone Cancer Center is to support transdisciplinary scientific research in the Cohorts for Environmental Exposures and Cancer (CEECR) Program for increasing understanding of environmental exposures that influence cancer risk, and the genetic, behavioral, and structural factors that modify risk across diverse populations. The CEECR Coordinating Center integrates efforts across the network of individual cohort studies with NIH program staff members and community partners to facilitate research through collaboration, coordination, and communication. We envision a consortium that, guided by our Coordinating Center, achieves a much greater level and pace of progress towards filling gaps in our knowledge of the environmental causes of cancer than would be possible by standalone research projects.

PI_NAMEs: MALECKI, KRISTEN MARY CHOSSEK;TRENTHAM-DIETZ, AMY  (contact)

PROGRAM_OFFICER_NAME: MAHABIR, SOMDAT

PROJECT_TERMS: Acceleration;Address;advocacy organizations;Attention;Behavioral;Biological;Cancer Biology;Cancer Burden;Cancer Center;cancer epidemiology;Cancer Etiology;cancer health disparity;cancer risk;Cancer Science;career;Cessation of life;Chemicals;cohort;Cohort Studies;Collaborations;Common Data Element;Communication;Communities;community engagement;community partners;Data;data dissemination;Data Science;data sharing;data submission;Deposition;Development;Ensure;Environment;environment related cancer;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Risk Factor;Environmental Science;epidemiology study;evidence base;Exclusion;experience;Fostering;Genetic;Goals;health disparity populations;Individual;Infrastructure;innovation;innovative technologies;Investments;Knowledge;Leadership;Malignant Neoplasms;Medical;member;Metadata;Mission;Morbidity - disease rate;mortality;multidisciplinary;outreach;Participant;Population;Population Heterogeneity;prevent;Prevention;Process;Productivity;programs;prospective;Public Health Practice;repository;Reproducibility of Results;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk;Role;Sampling;Science;Scientific Advances and Accomplishments;Secure;Source;structural determinants;Structure;Technology;Toxicology;Training;Translations;Trust;United States;United States National Institutes of Health;Universities;web site;webinar;Wisconsin

PROJECT_TITLE: Coordinating Center for the Cohorts for Environmental Exposures and Cancer Risk Program