NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Rare Diseases;Rehabilitation

PHR: NARRATIVE: CORE C (PROF) The Patient-Reported Outcomes/Function (PROF) Core (Core C) will provide comprehensive infrastructure for prospective collection of longitudinal functional outcomes and surveillance of treatment-related adverse events in a unique cohort of oropharynx cancer patients. This shared resource will play a critical role in patient-facing operations and data maintenance that are integral to all P01 Projects and Cores. The overarching aims of the PROF Core include improvement of patient recruitment and retention while optimizing longitudinal data collection and monitoring of patient symptoms via novel feedback loops and machine learning.

PI_NAMEs: BARBON, CARLY E. A. (contact)

PROJECT_TERMS: Adherence;Adverse effects;Adverse event;Aftercare;artificial intelligence model;Cancer Patient;Cancer Survivor;Cancer Survivorship;clinic ready;Clinical Data;Clinical Informatics;cohort;Collaborations;Collection;Consent;Cranial nerve diseases;dashboard;Data;Data Analyses;Data Collection;Data Element;data exchange;data infrastructure;data management;Data Reporting;Data Set;data sharing;data visualization;Database Management Systems;Databases;Deglutition Disorders;Development;Diagnosis;Elements;Enrollment;Ensure;Evaluation;Event;Face;Feedback;functional outcomes;functional status;Growth;Human Resources;human subject;improved;in silico;Individual;individualized feedback;Information Systems;Infrastructure;innovation;Machine Learning;machine learning algorithm;machine learning model;machine learning pipeline;Magnetic Resonance Imaging;Maintenance;malignant oropharynx neoplasm;Mandible;Measurement;Measures;Medical Records;Mental Health;Methodology;Methods;Mission;model development;Modeling;Monitor;multidisciplinary;novel;Online Systems;operation;Osteoradionecrosis;Outcome;Outcome Assessment;Outcome Measure;Patient Monitoring;patient oriented;Patient Outcomes Assessments;Patient Recruitments;patient retention;Patient-Focused Outcomes;Patients;Play;Population;Procedures;Process;Program Research Project Grants;programs;prospective;Psychometrics;quality assurance;Quality Control;Quality of life;Radiation;recruit;Registries;Reporting;Research;research and development;Research Personnel;Resource Sharing;Resources;response;retention rate;Risk;Role;Sampling;screening;Standardization;Subgroup;success;survivorship;Symptoms;Time;timeline;tool;treatment effect;trial enrollment;United States National Institutes of Health;Update;user-friendly;Validation;Visualization;Work

PROJECT_TITLE: Core C: Patient-Reported Outcomes & Function (PROF)


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CORAL GABLES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE: OVERALL The University of Miami’s Sylvester Comprehensive Cancer Center (Sylvester), the only NCI-designated cancer center in South Florida, is a source of discovery and innovation in cancer research, effective and inclusive approaches to education and training, novel community outreach and engagement activities for the prevention, diagnosis, and treatment of cancer, and hope for residents of its uniquely diverse catchment area. Focused on catchment area-relevant research, Sylvester’s four Research Programs span the spectrum of basic, clinical, translational, and population science research to reduce the human burden from cancer in the community the center serves. Sylvester leaders, clinicians and researchers work collaboratively to create a culture and environment that advances diversity, equity, and inclusion, and uses technologically advanced and culturally sensitive approaches to develop, evaluate, and implement novel treatments and effective interventional strategies that will sustainably and favorably impact cancer outcomes in South Florida and beyond.

PI_NAMEs: NIMER, STEPHEN D. (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Achievement;Address;Aging;anti-cancer research;Basic Science;Biotechnology;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Etiology;cancer health disparity;Cancer Model;cancer prevention;cancer risk;cancer therapy;Catchment Area;Clinical;Clinical Oncology;Clinical Research;Clinical Sciences;collaborative environment;Communities;community center;community engagement;Community Outreach;community partners;Comprehensive Cancer Center;cost efficient;County;Cultural Backgrounds;Development;Diagnosis;Direct Costs;Education;effective intervention;Ensure;Environment;Environmental Risk Factor;Epigenetic Process;equity, diversity, and inclusion;ethnic identity;Ethnic Origin;Exclusion;Extramural Activities;Faculty;Florida;Fostering;Funding;Future;Gender Identity;Genetic;Goals;Grant;Growth;Health;health disparity;health equity;Home;Human;improved;Infection;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;Intervention;investigator-initiated trial;Investments;K-Series Research Career Programs;Knowledge;Leadership;Learning;Localized Malignant Neoplasm;Malignant Neoplasms;Measurable;Medical;member;Mission;NCI-Designated Cancer Center;Neighborhoods;next generation;novel;Oncology;Outcome;outreach;Patient Care;Patient-Focused Outcomes;Patients;Peer Review;Persons;Pilot Projects;Population Sciences;Prevention;preventive intervention;Process;programs;Public Policy;Publications;Race;racial identity;recruit;Reporting;Research;Research Activity;Research Infrastructure;Research Personnel;Resource Sharing;Risk Factors;Role;Science;socioeconomic diversity;socioeconomics;Source;Strategic Planning;Technology;Therapeutic Intervention;Training;Training Activity;Training and Education;Training Programs;Translating;translational oncology;Translational Research;Tumor Biology;Universities;Work

PROJECT_TITLE: The Sylvester Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: GRAVES, DOROTHY  (contact)

PROJECT_TERMS: Administrative Coordination;Annual Reports;anti-cancer research;Area;Award;Basic Science;Budgets;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer research center director;Career Ladders;Catchment Area;Clinical Oncology;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Computer software;Contracts;Core Facility;dashboard;Data;Data Reporting;Decision Making;Dedications;Development;Diverse Workforce;Doctor of Philosophy;early-career faculty;Education;Education and Outreach;Ensure;equity, diversity, and inclusion;Evaluation;Evaluation Research;Evolution;Extramural Activities;Faculty Recruitment;Florida;Fostering;Funding;Funding Opportunities;Goals;Government;Grant;Growth;Human;Human Resources;Hybrids;Information Technology;Infrastructure;innovation;Institutional Review Boards;International;Investments;Journals;Leadership;Malignant Neoplasms;Manuscripts;Marketing;meetings;member;Mission;Modeling;NCI-Designated Cancer Center;Nurses;operation;Patient Care;Peer Review;Policies;Population Sciences;Preparation;Prevention;Process;programs;Publications;Publishing;recruit;Reporting;Research;Research Activity;Research Infrastructure;Research Support;Resource Sharing;Resources;Science;Services;Site Visit;skills;spelling;Strategic Planning;success;symposium;Training;Training and Education;Translational Activation;translational oncology;Translational Research;Universities;Update;Validation;Vision;Work

PROJECT_TITLE: Admin Core


PI_NAMEs: BURNSTEIN, KERRY L (contact)

PROJECT_TERMS: Advisory Committees;AIDS related cancer;American Cancer Society;anti-cancer research;Argentina;Award;Bahamas;Cancer Center Support Grant;cancer education;cancer health disparity;career;career development;Catchment Area;Clinical;clinical care;Clinical Oncology;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;continuing medical education;Databases;Development;Direct Costs;Doctor of Philosophy;early-career faculty;Education;Educational Activities;educational atmosphere;Ensure;Equity;equity, diversity, and inclusion;Evaluation;Faculty;Fellowship Program;Florida;Funding;graduate student;Grant;Gynecologic Oncology;Health Personnel;Health Professional;improved;Individual;innovation;Internships;Investments;K-Series Research Career Programs;Leadership;Malignant Neoplasms;Medical Students;member;Mentored Clinical Scientist Development Program;Mentors;mid-career faculty;Minority Groups;Mission;Monitor;multidisciplinary;NCI-Designated Cancer Center;Nigeria;Oncology;oncology program;Outcome;outreach;patient oriented;Peer Review;population based;Positioning Attribute;Postdoctoral Fellow;professor;Program Development;programs;recruit;Reporting;Research;research and development;Research Personnel;Resources;Scientist;Strategic Planning;Students;success;Training;Training Activity;Training and Education;Training Programs;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: GEORGE, SOPHIA HL (contact)

PROJECT_TERMS: Achievement;Adoption;Affect;anti-cancer research;Area;Award;Black race;Cancer Center;Cancer Center Support Grant;career;Caribbean region;Catchment Area;Central America;Clinical;clinical care;Clinical Oncology;Collaborations;Committee Members;Communities;community engagement;Community Outreach;community partners;Comprehensive Cancer Center;Country;County;Creativeness;Credentialing;demographics;diversity and equity;diversity and inclusion;Doctor of Philosophy;Economics;Educational process of instructing;Educational workshop;Endowment;Ensure;Environment;Equity;equity, diversity, and inclusion;Ethnic Origin;Evaluation;experience;Faculty;Female;Florida;Funding;Funding Mechanisms;Geography;Goals;Health;health equity;Heterogeneity;Hispanic;Home;Immigrant;implicit bias;improved;Individual;insight;Institution;Investments;Language;Latin America;Latino;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Measurable;Medical Oncologist;medical schools;member;migration;Minority Groups;Monitor;Names;novel;Outcome;outreach;Pattern;Policies;Politics;Population;Positioning Attribute;Process;Race;recruit;Reporting;Research;Resources;Role;Schools;socioeconomics;South America;symposium;synergism;Training;Training Activity;Training and Education;Travel;Underrepresented Minority;Universities;Woman;women faculty;Work;Workforce Development

PROJECT_TITLE: Plan to Enhance Diversity


PI_NAMEs: LOMBARD, DAVID BENNER (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Aging;aging process;anti-cancer research;Area;Automobile Driving;Award;bench to bedside;Biochemical;Bioinformatics;Bioinformatics Shared Resource;Biological Assay;Biological Markers;biomarker development;Biometry;Cancer Center Support Grant;Cancer Control;cancer genomics;cancer initiation;Cancer Model;Cancer Research Project;cancer risk;cancer subtypes;cancer therapy;carcinogenesis;Catchment Area;Cells;Clinic;Clinical;Clinical Oncology;Clinical Research;Clinical Trials;Collaborations;Comprehensive Cancer Center;County;Department of Defense;Differentiation Therapy;Discipline;Doctor of Philosophy;Dysmyelopoietic Syndromes;Effectiveness;Elderly;Enhancers;Environment;epigenetic drug;epigenetic marker;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Estrogen Receptors;Faculty;Florida;Flow Cytometry;Funding;Future;Gene Expression;Gene Expression Alteration;Gene Expression Regulation;Genetic Transcription;Genomics;Goals;graduate student;Grant;Growth Factor;Hematologic Neoplasms;Hematopoietic stem cells;Immunotherapy;improved;Infrastructure;inhibitor;innovation;insight;Institution;Investigation;Investments;Journals;KDM1A gene;Knowledge;Laboratories;leukemia/lymphoma;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;member;Mentors;Metabolic;Metabolism;Molecular;mouse model;Mutate;Mutation;Neoplasms;novel;Oncogenic;Outcome;outcome disparities;Paper;Patient-Focused Outcomes;Patients;Peer Review;Play;Population;Postdoctoral Fellow;PRC1 Protein;precision medicine;preclinical efficacy;preclinical study;Principal Investigator;Program Research Project Grants;programs;Publications;Publishing;recruit;Regulation;Reporting;Research;Research Personnel;Resource Sharing;Resources;response;Role;Science;Signal Transduction;Societies;socioeconomic disparity;Solid Neoplasm;Specialized Center;targeted treatment;Therapeutic;Therapeutic Intervention;therapy development;therapy resistant;Training;Training and Education;transcriptional reprogramming;Translating;translational oncology;treatment response;Tretinoin;Tumor Biology;tumor progression;tumorigenesis;United States National Institutes of Health;Work

PROJECT_TITLE: Cancer Epigenetics Research Program


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Rare Diseases

PI_NAMEs: RAI, PRIYAMVADA  (contact)

PROJECT_TERMS: Achievement;adduct;adipokines;androgen independent prostate cancer;anti-cancer research;AVPR1A gene;Basic Science;bench-to-bedside translation;Biological;biological adaptation to stress;Cancer Burden;cancer cell;Cancer Center Support Grant;Cancer Control;career;career development;Catchment Area;Cells;Cellular Stress;Clear cell renal cell carcinoma;Clinical Oncology;Clinical Trials;Collaborations;collaborative environment;Comprehensive Cancer Center;Coordination and Collaboration;County;Cues;Development;Doctor of Philosophy;Drug resistance;Environment;Esophageal Adenocarcinoma;Esophagus;Event;Faculty;Faculty Recruitment;Fibroblasts;fitness;Fostering;Funding;Funding Mechanisms;G-Protein-Coupled Receptors;Gastroenterology;Genetic Transcription;Goals;Grant;Helicobacter Infections;Homeostasis;Human Herpesvirus 8;Hypoxia;Immune;immune function;immunoregulation;Inflammation;Inflammatory;Infrastructure;innovation;Institution;Investments;Journals;Lead;Leadership;Link;Localized Malignant Neoplasm;Malignant Neoplasms;malignant stomach neoplasm;Mediating;meetings;MEKs;member;Mentors;Mission;Molecular;mortality;mTOR Inhibitor;neoplastic cell;next generation;novel;Obesity;Oncogenic;Oxidation-Reduction;Pancreatic Ductal Adenocarcinoma;Paper;Peer Review;Postdoctoral Fellow;precision medicine;Principal Investigator;pro-apoptotic protein;Production;Program Development;programs;Property;Proteins;Publications;Publishing;recruit;Reflux;Renal Cell Carcinoma;Replication Initiation;Reporting;Research;Research Personnel;Research Training;Resistance development;Resource Sharing;Resources;response;Role;Science;Scientist;Services;Signal Induction;Signal Pathway;Signal Transduction;STAT3 gene;stemness;Strategic Planning;Structure;Surgical Oncology;therapy resistant;Training;Training Programs;Translation Initiation;translational applications;translational oncology;translational potential;Translational Research;tumor;Tumor Biology;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Ubiquitination;undergraduate student

PROJECT_TITLE: Tumor Biology Research Program


NIH_SPENDING_CATS: Cancer;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: LANDGREN, CARL OLA  (contact)

PROJECT_TERMS: Agammaglobulinaemia tyrosine kinase;Allogenic;Alveolar Soft Part Sarcoma;androgen deprivation therapy;Applications Grants;Automobile Driving;Basic Science;bench to bedside;Biochemical;Biological;Biological Markers;biomarker identification;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research Program;Cancer Model;Cancer Patient;cancer therapy;catalyst;Catchment Area;Chronic Lymphocytic Leukemia;circulating biomarkers;Clinical;clinical application;clinical investigation;Clinical Oncology;clinical predictors;Clinical Research;Clinical Trials Design;Collaborations;Combined Modality Therapy;Communities;Complement;Comprehensive Cancer Center;Development;Developmental Therapeutics Program;Dimensions;Doctor of Philosophy;druggable target;Ensure;Epigenetic Process;Extramural Activities;Faculty;Faculty Recruitment;Feedback;Fostering;Funding;Funding Agency;Funding Mechanisms;Future;Goals;Grant;Immunosuppression;Immunotherapy;improved;improved outcome;Inflammation;innovation;insight;Institution;Intervention;Investments;Journals;KDR gene;Laboratories;Laboratory Research;large cell Diffuse non-Hodgkin's lymphoma;Leadership;lectures;LMO2 gene;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;member;Memorial Sloan-Kettering Cancer Center;Mission;Molecular Profiling;Names;NCI-Designated Cancer Center;neutrophil;next generation;novel;novel drug combination;novel strategies;novel therapeutic intervention;novel therapeutics;Oncology;oncology program;Outcome;Paper;PARP inhibition;patient population;Patient-Focused Outcomes;Patients;Peer Review;pembrolizumab;Phase;Play;pre-clinical;precision medicine;preclinical study;Principal Investigator;Prognosis;programs;Prostatectomy;Publications;Publishing;Radiation therapy;Readiness;Recording of previous events;recruit;Recurrence;Reporting;Research;Research Personnel;resistance mechanism;Resource Sharing;Role;Sarcoma;Science;Signal Transduction;Stem cell transplant;Strategic Planning;success;targeted treatment;Testing;Therapeutic;therapy resistant;TNF gene;Translating;translational applications;translational oncology;Translational Research;translational scientist;Treatment outcome;treatment response;Tumor Biology;Tumor Markers;Tyrosine Kinase Inhibitor;Update

PROJECT_TITLE: Translational and Clinical Oncology Research Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PI_NAMEs: PENEDO, FRANK J (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;African Caribbean;Aging;Area;Arts;Award;barrier to care;Behavior;Behavioral;Behavioral Research;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research;Cancer Control Research Program;Cancer Etiology;cancer health disparity;cancer heterogeneity;cancer risk;Cancer Survivorship;care delivery;Catchment Area;Clinic;Clinical;cohort;Collaborations;collaborative environment;college;Communication;Communities;community based participatory research;community based research;Comprehensive Cancer Center;County;data visualization;Death Rate;design;Diagnosis;Disparate;Dissemination and Implementation;dissemination science;Doctor of Philosophy;Education;eHealth;Electronic Health Record;Emotional;Ensure;Epidemiology;Equity;Ethnic Origin;Etiology;evidence base;Extramural Activities;Faculty Recruitment;faculty support;fire fighter;Florida;Funding;Future;gastrointestinal;Generations;Goals;Grant;Health behavior;health equity;Health Knowledge Attitudes Practice;Health system;Heterogeneity;Hispanic;Home;hormone related cancer;Human;implementation science;improved outcome;Incidence;Individual;Infection;innovation;Institution;Interdisciplinary Study;Intervention;Investments;Journals;Latino;Life Style;Linguistics;Malignant Neoplasms;Medical;medical schools;Medicine;member;Mentors;Methodology;metropolitan;mHealth;mhealth interventions;Mission;Music;National Cancer Institute;National Institute on Minority Health and Health Disparities;novel;Nutritional;Occupational;Oncology;Outcome;Outcome Assessment;outreach;Paper;Patient Care;Patient Outcomes Assessments;Patients;Peer Review;Persons;Physical activity;Policies;Population;Population Heterogeneity;post-doctoral training;Prevalence;Prevention;Productivity;programs;psychosocial;Publications;Publishing;Race;Reporting;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Resource Sharing;Resources;Risk;risk stratification;Schools;Science;Scientific Advances and Accomplishments;Scientist;Screening for cancer;Secure;sexual identity;Site;social epidemiology;Socioeconomic Status;Strategic Planning;survivorship;symptom management;Targeted Research;Testing;Time;tool;Training;Training Programs;Translational Research;Treatment Efficacy;Triage;Universities;Vulnerable Populations

PROJECT_TITLE: Cancer Control Research Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PI_NAMEs: KOBETZ, ERIN N (contact)

PROJECT_TERMS: Address;Advocate;Age;Algorithms;Area;Articulation;Automobile Driving;Awareness;Back;Basic Science;bench to bedside;Breathing;burden of illness;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer education;cancer health disparity;cancer prevention;cancer risk;Caribbean region;Catchment Area;Clinical Research;Clinical Trials;Collaborations;Communities;community advisory board;community center;community engagement;Community Outreach;community partners;community research;Complex;Comprehensive Cancer Center;County;Cultural Backgrounds;Data;Data Analytics;data resource;Data Set;data visualization;demographics;Disease;disorder risk;Education;empowerment;Endowment;Ensure;equity, diversity, and inclusion;Ethnic Origin;Etiology;evidence base;expectation;Faculty;Florida;Funding;Future;Geography;Glean;Goals;health equity;health equity promotion;Health Policy;Healthcare Systems;Heterogeneity;Home;human old age (65+);Income;Inequality;Infrastructure;interest;International;Investments;Language;Latin America;Leadership;Localized Malignant Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;member;metropolitan;Monitor;Names;NCI-Designated Cancer Center;novel;older adult;Oncology;Outcome;outreach;patient oriented;Persons;Physicians;Policies;Population;Population Research;programs;Race;Reporting;Research;Research Activity;Research Support;Risk Factors;Scientist;screening;Services;sexual identity;Shapes;Site;sociodemographics;Strategic Planning;Structure;Subgroup;Training and Education;Translating;Translational Research;Work;World Health Organization

PROJECT_TITLE: COE


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PROJECT_TERMS: Acceleration;Address;American Cancer Society;anti-cancer research;Area;Award;biomarker development;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Model;career;career development;Career Mobility;Catchment Area;Clinical;Clinical Research;Clinical Trials;Collaborations;community engagement;Community Outreach;Comprehensive Cancer Center;cost;COVID-19 pandemic;Dedications;Development;Enrollment;experience;Extramural Activities;Faculty;Florida;Foundations;Funding;Funding Mechanisms;Funding Opportunities;Goals;Grant;Growth;Histology;Home;human cancer mouse model;Hybrids;Image;in vivo;innovation;insight;Institution;instrument;interdisciplinary collaboration;Investments;Journals;Malignant Neoplasms;member;minority investigator;Mission;NCI-Designated Cancer Center;novel;Organoids;Participant;Patients;Peer Review;Population Sciences;Principal Investigator;Process;Productivity;programs;Publications;recruit;Reporting;Research;Research Personnel;Research Priority;Research Project Grants;Resistance development;Resource Sharing;Review Committee;Science;Services;Source;Specimen;Standardization;Strategic Planning;therapy development;Time;translational pipeline;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;Work;Xenograft procedure

PROJECT_TITLE: Developmental Funds


PI_NAMEs: GRILLS, GEORGE S. (contact)

PROJECT_TERMS: Administrator;Advisory Committees;anti-cancer research;Award;Behavioral Research;Bioinformatics;Biometry;Cancer Center Support Grant;Cancer Control;cancer genomics;Cancer Model;Catchment Area;Clinical Oncology;Clinical Research;community based research;Comprehensive Cancer Center;cost effective;Data Analyses;data management;Development;Doctor of Philosophy;Educational workshop;Emerging Technologies;Ensure;Epigenetic Process;experience;Faculty;Feedback;Flow Cytometry;Future;Goals;Grant;Growth;Human Resources;implementation facilitation;improved;innovation;instrument;Journals;large scale data;Malignant Neoplasms;Measures;member;Methods;new technology;operation;Population Sciences;Procedures;Process;Professional Education;programs;Proteomics Shared Resource;Publications;Qualifying;Quality Control;recruit;Reporting;Reproducibility;Research;research study;Resource Sharing;Scientist;service coordination;Services;Strategic Planning;Technology;Training;Training and Education;translational oncology;Translational Research;Tumor Biology;Work

PROJECT_TITLE: Shared Resource Management


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Acceleration;Adherence;Advisory Committees;anti-cancer research;Area;authority;Basic Science;Big Data Methods;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer health disparity;Catchment Area;Clinic;Clinical;clinical care;Clinical Oncology;Clinical Research;Communication;Communities;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;Counseling;County;dashboard;Data;Decision Making;Dedications;Development;Education;Effectiveness;Endowment;Engineering;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;Evolution;experience;Faculty;Faculty Recruitment;Feedback;Florida;Goals;Growth;Growth and Development function;high standard;informatics tool;Investments;Leadership;Malignant Neoplasms;meetings;member;Mentorship;Mission;NCI-Designated Cancer Center;next generation;oncology service;Physicians;Policies;population based;Population Sciences;Positioning Attribute;Precision Medicine Initiative;Process;Productivity;programs;recruit;Research;Resource Sharing;Resources;Review Committee;Role;Science;Scientific Advances and Accomplishments;Services;Strategic Planning;Structure;success;support tools;Teacher Professional Development;timeline;Training;Training and Education;Translating;translational oncology;Translational Research;Universities;Update;Vision;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: TRENT, JONATHAN C (contact)

PROJECT_TERMS: Address;Age;anti-cancer research;Cancer Burden;Cancer Center Support Grant;Cancer Patient;Catchment Area;Clinical Data;Clinical Management;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Comprehensive Cancer Center;Data;data integrity;data management;Data Management Resources;Data Reporting;Development;Disease;Enrollment;Ensure;Ethics;Ethnic Origin;Gender;Individual;Industry;Infrastructure;Institutional Policy;Intervention;Language;Malignant Neoplasms;Mission;Monitor;operation;Operations Research;outreach;Participant;participant enrollment;participant safety;patient safety;Patients;phase 1 study;Policies;Principal Investigator;Protocols documentation;quality assurance;Quality Control;Race;Regulation;Reporting;Research;Research Infrastructure;Research Personnel;research study;Safety;safety study;Services;sexual identity;Site;sociodemographics;Strategic Planning;System;Training;Universities;Writing

PROJECT_TITLE: Clinical Protocol and Data Management


PROJECT_TERMS: anti-cancer research;authority;Biometry;Cancer Center Support Grant;cancer research center director;Catchment Area;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;clinically relevant;Comprehensive Cancer Center;dashboard;Data;data registry;design;Disease;Doctor of Philosophy;Elements;Enrollment;Ensure;Exercise;expedited review;Goals;Grant;Growth;human subject;Individual;Industry;Institutional Review Boards;Leadership;Letters;Malignant Neoplasms;meetings;Mission;Modeling;Monitor;multidisciplinary;Peer Review;Physicians;Policies;Population;Population Sciences;Procedures;Process;programs;prospective;Protocols documentation;recruit;Reporting;Research;Research Personnel;research study;Resources;Review Committee;Safety;Site;Specific qualifier value;Strategic Planning;System;timeline;Translational Research;tumor registry;Universities;Writing

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention

PI_NAMEs: CARRASQUILLO, OLVEEN  (contact)

PROJECT_TERMS: Address;anti-cancer research;Behavior Therapy;Behavioral Research;behavioral study;Bioinformatics Shared Resource;Biometry;Black race;Blood;Cancer Burden;Cancer Center Support Grant;Cancer Control;cancer health disparity;Catchment Area;Clinic;Clinical;Clinical Oncology;Clinical Research;Code;Collection;Communities;community based research;community engagement;community research;community setting;Comprehensive Cancer Center;Consent;Consent Forms;cost effective;Data;Data Collection;Databases;Development;Devices;Eligibility Determination;Ensure;Epigenetic Process;Ethnic Origin;evidence base;field study;Florida;Focus Groups;Future;gender diverse;Genetic Transcription;Goals;Haitian;health equity;Hispanic;Individual;Intervention;Interview;Journals;Laboratories;Language;Latino;Linguistics;Location;Malignant Neoplasms;Measures;Medical Records;member;Methodological Studies;mHealth;Multilingualism;Participant;Population Heterogeneity;Population Research;Population Study;preference;Prevention;Principal Investigator;programs;psychosocial;Psychosocial Assessment and Care;Publications;Qualitative Research;Race;recruit;Reporting;Research;Research Methodology;research study;Research Support;Resource Sharing;Saliva;sample collection;screening;Services;Sex Orientation;Site;Socioeconomic Status;Software Tools;Spanish;Specimen;Strategic Planning;Surveys;survivorship;System;Target Populations;therapy development;tool;translational oncology;Translational Research;translational study;Translations;Tumor Biology;Work

PROJECT_TITLE: Behavioral and Community-Based Research Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: GUO, YAN  (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;analysis pipeline;anti-cancer research;Artificial Intelligence;Award;Awareness;Basic Science;Behavioral Research;Big Data;Bioinformatics;Bioinformatics Shared Resource;biomarker selection;Biometry;Biostatistics Shared Resource;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genomics;cancer heterogeneity;Cells;Clinic;Clinical;Clinical Oncology;Clinical Research;Clinical Research Protocols;Clinical Sciences;Clinical Trials;Clinical Trials Design;cloud based;cluster computing;community based research;Comprehensive Cancer Center;Consultations;cost effective;Data;data acquisition;Data Analyses;data management;data preservation;data visualization;deep learning;design;Doctor of Philosophy;drug response prediction;Educational process of instructing;Educational workshop;Emerging Technologies;Ensure;Epigenetic Process;experience;Extramural Activities;Flow Cytometry;Future;Generations;genomic data;Grant;Growth;Guidelines;High Performance Computing;high throughput technology;Human Resources;Individual;Journals;Laboratories;large scale data;lectures;Malignant Neoplasms;Manuscripts;Measures;member;Methodology;Monitor;multidimensional data;multiple omics;novel;Phase;population based;Population Sciences;power analysis;precision medicine;Preparation;Principal Investigator;programs;Protocols documentation;Publications;recruit;Reporting;Reproducibility;Research;Research Design;Research Personnel;research study;Resource Sharing;Resources;Safety;Sample Size;Science;Services;Statistical Computing;Strategic Planning;success;System;Techniques;Training;Training and Education;translational oncology;Translational Research;translational study;Tumor Biology;United States National Institutes of Health;Work

PROJECT_TITLE: Biostatistics & Bioinformatics Shared Resource


PI_NAMEs: WIEDER, ERIC  (contact)

PROJECT_TERMS: Activation Analysis;anti-cancer research;antigen detection;Apoptosis;Award;Basic Science;Bioinformatics;Biometry;cancer cell;Cancer Center Support Grant;Cancer Control;cancer genomics;Cancer Model;cell analyzer;Cell Cycle;Cell Separation;Cell surface;Cells;Clinical Oncology;Clone Cells;Complex;Complex Mixtures;Comprehensive Cancer Center;cost effective;Cytometry;Data;data acquisition;Data Analyses;data management;design;Development;Epigenetic Process;Equipment;Experimental Designs;experimental study;Florida;Flow Cytometry;Flow Cytometry Shared Resource;Fluorescence;Fluorescence-Activated Cell Sorting;Funding;Future;Generations;Genomics;Grant;Human Resources;Image;Immunophenotyping;improved;innovative technologies;instrument;instrumentation;International;Investments;Journals;Maintenance;Malignant Neoplasms;Measurement;meetings;member;Methods;multiple omics;new technology;Normal Cell;Normal tissue morphology;novel;Pathway interactions;Phenotype;Ploidies;Population;Preparation;programs;Proliferating;Publications;Quality Control;Reporting;Reproducibility;Research;Research Personnel;Research Support;Resolution;Resource Sharing;Sampling;Services;Signal Transduction;single cell analysis;Societies;Sorting;Strategic Planning;success;Suspensions;Technical Expertise;Technology;Tissues;Training;Training and Education;translational oncology;Translational Research;Tube;Tumor Biology;tumor microenvironment;Work

PROJECT_TITLE: Flow Cytometry Shared Resource


PI_NAMEs: WILLIAMS, SION LLEWELYN (contact)

PROJECT_TERMS: Address;Advisory Committees;anti-cancer research;Apical;Applications Grants;Award;Bioinformatics;Biometry;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genomics;cancer heterogeneity;Cancer Model;Cells;Chromium;Clinical Oncology;Comprehensive Cancer Center;Consultations;cost effective;Data;data sharing;design;digital;Education;Educational workshop;Emerging Technologies;Epigenetic Process;epigenomics;Extramural Activities;Faculty;Feedback;Flow Cytometry;Future;Gene Expression Profiling;Generations;Genomics;Genotype;Goals;Growth;Human Resources;Immunooncology;Individual;instrument;Investments;Journals;Laboratories;Leadership;Libraries;Light;Liquid substance;Malignant Neoplasms;Manuscripts;member;Metagenomics;microgenomics;Mission;multiple omics;nano-string;next generation sequencing;Nucleic Acids;Preparation;Production;programs;Publications;Quality Control;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Sampling;sequencing platform;Services;square foot;Strategic Planning;Surveys;Technology;Training;transcriptomics;translational oncology;Tumor Biology;tumor heterogeneity;tumor microenvironment;Validation;whole genome;Work

PROJECT_TITLE: Onco-Genomics Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: MERCHANT, NIPUN B. (contact)

PROJECT_TERMS: Adherence;Award;Behavioral;Behavioral Research;biobank;Bioinformatics;Biological Specimen database;Biometry;Biopsy;Blood;Cancer Center Support Grant;Cancer Control;cancer genomics;Cancer Model;Cataloging;Catalogs;Cell Culture Techniques;Cell Separation;Clinical;Clinical Data;Clinical Oncology;Clinical Research;cohort;Collection;Communication;Communities;community based research;Complex;Comprehensive Cancer Center;Consent;Correlative Study;cost effective;Cryopreservation;Data;data management;Database Management Systems;Databases;Dedications;design;Development;Diagnosis;Disease;DNA Sequence Alteration;Education;Educational workshop;Enrollment;Environment;Epigenetic Process;Extramural Activities;Goals;Grant;Heterogeneity;Histologic;Hospitals;Informatics;Informed Consent;innovation;Inpatients;insight;Journals;Laboratories;laboratory manuals;Malignant Neoplasms;Management Information Systems;Medicine;meetings;member;Metadata;Methodology;multidisciplinary;multiple omics;novel therapeutic intervention;Oncology;Operative Surgical Procedures;Organoids;Outpatients;Participant;participant enrollment;participant retention;Pathologist;Pathology;Patient Care;patient derived xenograft model;Patient Recruitments;patient retention;Patients;Peripheral Blood Mononuclear Cell;Plasma;Population Study;Preparation;Process;programs;protocol development;Protocols documentation;Publications;Quality Control;Reporting;Research;Research Personnel;research study;Research Support;Resource Sharing;Resources;Retrieval;sample archive;sample collection;Sampling;screening;Secure;Serum;Services;shared database;Site;Specimen;Strategic Planning;System;Techniques;Therapeutic Intervention;Therapeutic Trials;Tissue Microarray;tissue processing;Tissues;tool;Training;Training and Education;translational cancer research;translational oncology;Translational Research;Tumor Biology;Universities;Work

PROJECT_TITLE: Biospecimen Shared Resource


PI_NAMEs: BILBAO, DANIEL  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Antineoplastic Protocols;Applications Grants;Award;Basic Science;Bioinformatics Shared Resource;Bioluminescence;biomarker discovery;Biometry;Cancer cell line;Cancer Center Support Grant;Cancer Control;cancer genomics;Cancer Model;Catchment Area;Clinical Chemistry;Clinical Oncology;Clinical Research;Comprehensive Cancer Center;Consultations;Data;data acquisition;Data Analyses;Data Collection;design;Detection;Development;digital;digital pathology;Doctor of Philosophy;Drug Delivery Systems;drug development;drug efficacy;Drug Evaluation;Drug Formulations;Drug toxicity;efficacy evaluation;Epigenetic Process;Experimental Designs;Flow Cytometry Shared Resource;Fluorescence;Future;Generations;Genes;Genetically Engineered Mouse;Genomics;Goals;Grant;Growth;Hematologic Neoplasms;Hematology;Histology;Histopathology;hormone related cancer;Human;human cancer mouse model;human model;Human Resources;humanized mouse;Image;Image Analysis;imaging modality;Immunohistochemistry;in vivo;in vivo imaging;in vivo Model;Infrastructure;instrument;instrumentation;interest;Investments;Journals;leukemia/lymphoma;Magnetic Resonance Imaging;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Manuscripts;meetings;member;Mission;Modality;model organism;Modeling;mouse model;Mus;non-invasive imaging;novel;nuclear imaging;optical imaging;patient derived xenograft model;PET/CT scan;Positron-Emission Tomography;pre-clinical;preclinical development;preclinical study;Procedures;programs;Proteomics;Protocols documentation;Publications;recruit;Reporting;Research;Research Personnel;Resource Sharing;Resources;Running;sample collection;Scanning;Services;Slide;square foot;Stains;success;Talents;Technology;Testing;Therapeutic;Toxic effect;Training;Training and Education;translational oncology;Translational Research;translational study;Treatment Protocols;treatment response;tumor;Tumor Biology;ultrasound;Work;Xenograft Model

PROJECT_TITLE: Cancer Modeling Shared Resource


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Despite the best cybersecurity measures, ransomware attacks have occurred in Radiation Oncology with devastating effects. Our project proposes novel methods to improve ransomware attack resiliency and uses engineering principles to quantitatively and qualitatively evaluate the proposed techniques. The developed methods can help improve outcomes for cancer patients by enabling safer and timelier radiotherapy treatments in ransomware attack situations and by reducing the impact of ransomware attacks on patients impacted with social determinants of health.

PI_NAMEs: LAMB, JAMES MICHAEL;SULLIVAN, SARAH ELIZABETH;VINOGRADSKIY, YEVGENIY  (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Systems Engineering for Ransomware Attack Response Resiliency in Radiation Oncology

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: PROJECT NARRATIVE Disparities in pediatric asthma are highly influenced by multifactorial determinants, particularly in rural and underresourced areas, such as Arkansas. Given the complex relationship between of these determinants, asthma outcomes, and the need to investigate the extent of how patient, provider, and community-level variation impacts our population, this proposal aims to improve the identification and understanding of multifactorial, multilevel determinants of asthma through 1) engagement of patients with asthma and their caregivers, 2) uncovering unknown region and population-specific factors underlying differences in outcomes, and 3) examining variation in asthma outcomes through multilevel analyses (patient, provider, community). There are few population-level analyses of pediatric asthma in rural and underresourced settings, and this proposal represents a foundational step in impacting disparity and inequity in asthma, while also providing findings that will inform innovative patient-centered, population-based interventional trials targeting high-risk pediatric asthma in Arkansas with broader implications as a model for investigations among other rural at-risk populations.

PI_NAMEs: JEFFERSON, AKILAH ANDREA (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Address;administrative database;Area;Arkansas;Asthma;Automobile Driving;Black race;care outcomes;Caregivers;Caring;Characteristics;Child;Child Development;Child Health;Childhood;Childhood Asthma;Chronic;clinically relevant;Communities;community intervention;community-level factor;Complex;Data;Databases;design;Development;Dimensions;Disparate;Disparity;Emergency department visit;Ensure;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;Exhibits;experience;Extramural Activities;Face;Focus Groups;Foundations;Funding;Geography;Goals;Health;health care service utilization;Health Disparities Research;health equity promotion;Health Sciences;high risk;Hospitalization;Household;improved;indexing;Individual;Inequity;informant;Inhalators;innovation;Inpatients;Intervention;Intervention Trial;Interview;Investigation;K-Series Research Career Programs;Knowledge;Logistic Regressions;Measures;Medicaid;Mentors;Mentorship;Methods;minority children;Modeling;Morbidity - disease rate;multilevel analysis;Neighborhoods;Odds Ratio;Outcome;outcome disparities;patient engagement;patient oriented;Patients;Pharmaceutical Preparations;Population;population health;Population Intervention;Populations at Risk;Poverty Areas;preference;Prevalence;Provider;provider intervention;Quality of Care;Race;racial minority;racial minority population;racial population;Research;Research Methodology;Research Personnel;Resources;Risk;Risk Factors;Risk Management;Rural;rural area;School Nursing;success;tool;Training;Variant

PROJECT_TITLE: Multifactorial Asthma Determinants in Underresourced Pediatric Populations

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (MA)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

ORG_STATE: NY

PHR: Despite large-scale, nationwide efforts to better address suicidal behavior in Veterans at high risk, the development of interventions that target some of the key risk factors associated with suicide remains limited. This study aims to collect pilot data to test feasibility/acceptability of a novel adjunctive evidence-based cognitive remediation (CR) therapy with manualized “Bridging” sessions for transfer and practice of problem- solving strategies for real-world stressors, including those that trigger suicidal thoughts. This 10-week (20 session) Neuropsychological Educational Approach to Cognitive Remediation CR+Bridging telehealth intervention will be administered virtually via HIPPA-compliant services to 36 Veterans with major depressive disorder and a history of suicide attempt(s). Pre-, post-treatment, and follow-up assessments of neurocognitive, clinical, social, and real-world functioning also will be conducted. This study has potential for high public health impact and promise to help improve quality of life for Veterans at high risk for suicide.

PI_NAMEs: HAZLETT, ERIN A. (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Aftercare;Behavior;Behavioral;Client satisfaction;Clinical;Cognitive;cognitive control;cognitive function;cognitive rehabilitation;Cognitive remediation;cognitive skill;cognitive testing;Cognitive Therapy;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;daily functioning;Data;Decision Making;depressive symptoms;Education;Emotions;Evaluation;evidence base;Executive Dysfunction;executive function;feasibility testing;Feeling suicidal;follow up assessment;follow-up;Gambling;Goals;high risk;Impairment;implementation intervention;improved;Individual;innovation;Intervention;Intervention Studies;Iowa;Language;Major Depressive Disorder;Manuals;Measures;Mental Depression;Mental disorders;military veteran;Names;Neurocognitive;Neurocognitive Deficit;Neuronal Plasticity;Neuropsychology;novel;older adult;Participant;Patients;Pattern;Performance;Pilot Projects;Problem Solving;Public Health;Quality of life;Questionnaires;Recording of previous events;Recovery;recruit;Rehabilitation therapy;Reporting;response;Risk Factors;Sampling;Schizophrenia;Semantics;Services;Severities;skills;social;Social Adjustment;Social Distance;stressor;suicidal behavior;suicidal risk;Suicide;Suicide attempt;symptomatology;targeted treatment;telehealth;Testing;Therapeutic Intervention;therapy development;Thinking;Time;tool;treatment as usual;Veterans;virtual;Work

PROJECT_TITLE: A Novel Cognitive Remediation Intervention Targeting Poor Decision-Making and Depression in Veterans at High Risk for Suicide: A Safe,Telehealth Approach During the COVID-19 Pandemic

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: MILWAUKEE

ORG_NAME: CLEMENT J. ZABLOCKI VA MEDICAL CENTER

ORG_STATE: WI

PHR: This project is relevant to public health because it will provide critical information on the neurological and behavioral consequences of mild traumatic brain injury (mTBI). The proposed research is relevant to the VA Office of Rehabilitation Research and Development’s mission because it is directed toward studying the effectiveness of pharmaceutical interventions in the treatment of comorbid mTBI-addiction. The Department of Defense and the Defense and Veteran's Brain Injury Center have estimated that 22% of all combat casualties from the conflicts in Iraq and Afghanistan are brain injuries. As these military personnel transition into the VA healthcare system, many of the long-term effects of these traumatic brain injuries have not been clearly defined or are not known. Some evidence exists to indicate that exposure to traumatic brain injury may influence drug addiction and relapse. Our preliminary studies have supported this assertion. This study will explore the chronicity of this relationship and explore interventions to alleviate its effects.

PI_NAMEs: STEMPER, BRIAN D (contact)

PROJECT_TERMS: Abstinence;abuse liability;Accident and Emergency department;addiction;addiction liability;Afghanistan;Air Force Personnel;American;Analgesics;Animals;Behavior;Behavioral;Blast Injuries;Brain;Brain Injuries;Brain region;brain tissue;Chemistry;Chronic;Clinical Treatment;combat;combat casualty;comorbidity;craving;Data;Department of Defense;Devices;Diffusion Magnetic Resonance Imaging;Disease;Dose;Drug abuse;Drug Addiction;drug efficacy;drug of abuse;drug relapse;drug seeking behavior;effectiveness study;epidemiology study;Excision;experience;Experimental Models;Exposure to;Freedom;frontal lobe;Functional Magnetic Resonance Imaging;Gliosis;hazard;Healthcare Systems;heroin use;high risk;Human;Image;Imaging Techniques;Immunohistochemistry;improved;Incidence;Individual;Inflammatory Response;Injury;Intake;Intervention;Intravenous;Investigation;Iraq;Laboratories;Life;Link;Long-Term Effects;Magnetic Resonance Imaging;Measures;Medial;mild traumatic brain injury;Military Personnel;military veteran;Mission;misuse of prescription only drugs;Modeling;Nervous System Trauma;neuroimaging;Neurologic;Non-Steroidal Anti-Inflammatory Agents;operation;Opiate Addiction;Opioid;opioid exposure;opioid use;Outcome;Oxycodone;oxycodone seeking;Pathologic;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacological Treatment;Pharmacotherapy;Phase III Clinical Trials;Play;Population;pre-clinical;preclinical study;Predisposition;Prefrontal Cortex;prescription opioid;Prevalence;Property;Psychological reinforcement;Public Health;Publishing;Rattus;Recording of previous events;rehabilitation research;Reinforcement Schedule;Relapse;Research;research and development;response;Risk;Rodent;Rodent Model;Role;Self Administration;Structure;Substance abuse problem;Techniques;Testing;Time;Traumatic Brain Injury;Veterans

PROJECT_TITLE: Determination of factors that influence addiction-related outcomes following brain injury

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Bats are reservoirs of several human pathogenic viruses with pandemic potential, including coronaviruses and henipaviruses. Currently, there are no closed breeding colonies of bats that host these viruses, thus, it is difficult to study the viruses in their natural reservoir hosts. We will establish breeding colonies of horseshoe bats and Indian flying foxes to provide bats, cells and reagents for researchers who study SARS-related coronaviruses and Nipah virus.

PI_NAMEs: SCHOUNTZ, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: WOODSON, SARA ELAINE

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Address;Affect;Animal Model;Animals;Archives;Asia;Bangladesh;bat-borne;betacoronavirus;biobank;Biology;Bone Marrow;Breeding;Caring;Cell Culture Techniques;cell immortalization;Cell Line;Cells;Chiroptera;Clinical;Colorado;Communities;Coronavirus;Coronavirus Infections;coronavirus treatment;cytokine;deep sequencing;Dendritic Cells;detection assay;Development;Disease;Disease Outbreaks;Ebola virus;Encephalitis;Event;experimental study;Family Pteropodidae;Filovirus;Flow Cytometry;FLT3 ligand;Freezing;Future;Genus Pteropus;germ free condition;Granulocyte-Macrophage Colony-Stimulating Factor;Health;Hendra Virus;Henipavirus;Henipavirus Infections;Hepatitis C virus;Human;Immune;Immune response;Immunology;improved;In Vitro;in vitro testing;in vivo;Individual;Infection;Infection Control;Infectious Diseases Research;Innate Immune Response;Interferon Type II;Interleukin-2;Interleukin-4;Kinetics;Knowledge;Laboratories;Macrophage;Mammals;Marburgvirus;Measles;metabolomics;Methodological Studies;Middle East Respiratory Syndrome Coronavirus;Modeling;Monoclonal Antibodies;mortality;Mumps;Natural Immunity;Nipah Virus;novel;novel therapeutic intervention;offspring;Outcome;pandemic potential;Paramyxovirus;pathogen;pathogenic virus;Pathogenicity;Pathology;Physiology;Predisposition;prevent;Primary Cell Cultures;Proteins;Proteomics;Quarantine;Reagent;Recombinant Cytokines;Recombinant Proteins;Research;Research Personnel;Resolution;Resources;Risk;Sarbecovirus;SARS coronavirus;Severe Acute Respiratory Syndrome;Study models;Surface Antigens;T-Lymphocyte;Testing;Therapeutic;Tissues;trait;transcriptomics;Universities;Viral;Virus;Virus Diseases;Work;Zoonoses

PROJECT_TITLE: Establishment of a Bat Resource for Infectious Disease Research


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Charcot-Marie-Tooth Disease;Genetics;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The Integrated Stress Response (ISR) signaling pathway helps cells adapt to various conditions of stress, and abnormal ISR signaling is associated with various metabolic and neurodegenerative diseases. This pathway simultaneously activates gene transcription and suppresses general mRNA translation. Here, we propose to determine how stress-responsive transcripts bypass mRNA translation blocks associated with ISR, and determine their significance in stress adaptation and disease manifestation.

PI_NAMEs: RYOO, HYUNG D (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Address;Amino Acyl-tRNA Synthetases;biological adaptation to stress;Bypass;Cells;Cellular Stress;Charcot-Marie-Tooth Disease;Disease;DNA Sequence Alteration;Drosophila genus;Gene Expression;Genes;Genetic;Genetic Screening;Genetic Transcription;Goals;Heterozygote;human disease;interest;Mediating;Messenger RNA;Metabolic Diseases;Modeling;mRNA Translation;Mutation;Neurodegenerative Disorders;novel therapeutic intervention;Organism;Pathway interactions;Peptide Initiation Factors;Phosphotransferases;Physiological;Process;programs;Regulation;Research;Ribosomes;ribosomopathy;Signal Pathway;Stress;Stress Response Signaling;Testing;tool;Transcript;Translational Repression;Translations

PROJECT_TITLE: Translational control of stress response signaling

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PI_NAMEs: PICCI, GIORGIA  (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TITLE: Biological embedding of dimensional adversity: Developmental pathways toward psychopathology


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Neurosciences

ORG_CITY: DOYLESTOWN

ORG_NAME: BARUCH S. BLUMBERG INSTITUTE

PHR: Project Narrative Hepatitis B (HB) continues to be the world’s leading cause of hepatocellular carcinoma. Although a vaccine is preventive, none of the current therapies are curative for patients who have already been infected, even after ten years of use. New effective medicines are urgently needed. We propose to develop small molecule antivirals that can be selectively delivered to the liver where HB virus resides and significantly reduce the levels of multiple HBV gene products including hepatitis B surface antigen. This project will advance an innovative class of anti- HBV compounds towards preclinical animal efficacy studies.

PI_NAMEs: DU, YANMING  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: absorption;Acids;Acute;Address;analog;animal efficacy;Animal Model;anti-hepatitis B;Anti-viral Agents;Binding Proteins;Biochemical;Blood;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Caco-2 Cells;carbene;Carboxylic Acids;Cell Line;Cellular Assay;Cessation of life;Chronic;Chronic Hepatitis B;Cirrhosis;curative treatments;cytotoxicity;design;Development;DNA-Directed DNA Polymerase;Dose;Drug Kinetics;efficacy study;Elements;Employment;Equilibrium;Evaluation;Exposure to;Fatty Acids;Future;gene product;Generations;Goals;Hepatitis B;Hepatitis B e Antigens;Hepatitis B Surface Antigens;Hepatitis B Therapy;Hepatitis B Virus;Hepatocyte;HepG2;Human;Immune;Immune response;improved;In Vitro;in vitro Assay;in vivo;inhibitor;innovation;Intestinal Absorption;Intestines;Lead;lead optimization;lipophilicity;Liver;Liver Cirrhosis;Liver Failure;Liver Microsomes;Medicine;Mus;neurotoxicity;novel;novel strategies;OATP Transporters;Oral;Organ;oxidation;Parents;Patients;Pegylated Interferon Alfa;Peripheral Nerves;Permeability;Persons;Pharmaceutical Preparations;Plasma;Polynucleotide Adenylyltransferase;Positioning Attribute;pre-clinical;Preventive;Primary carcinoma of the liver cells;primary endpoint;Prodrugs;Property;Refractory;Reporting;Risk;Route;Safety;Series;Serum;side effect;Site;small molecule;standard of care;Stream;Surface Antigens;System;Testing;Therapeutic;therapy design;Time;tissue culture;Tissues;Toxic effect;Transaminases;Vaccines;Viral;viral DNA;Viral Proteins;viral RNA;Viremia;Virus Replication;Work

PROJECT_TITLE: Liver Targeting Dihydroquinolizinone (DHQ) Molecules as Hepatitis B Virus Antivirals with Reduced Toxicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(82)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAN DIEGO

ORG_NAME: ELGIA THERAPEUTICS, INC.

ORG_STATE: CA

PHR: PROJECT NARRATIVE The protease caspase-6 contributes to inflammation, neurodegeneration, and protein aggregation in neurodegenerative diseases like Alzheimer’s (AD). We have developed highly potent inhibitors of caspase-6 that gain exquisite selectivity by binding covalently to a unique cysteine residue in the substrate-binding groove. This Phase I STTR project will further develop this novel series of inhibitors and will utilize PK and tissue distribution studies to select the most promising compounds for AD disease-specific animal models. With potent inhibitors in hand, we will be able to elucidate target half-life and engagement with an established click-based probe of aCasp6 binding. This work will enable design of a future studies that will determine whether caspase-6 inhibitors are effective at blocking disease progression in animal models.

PI_NAMEs: ARKIN, MICHELLE ;CANAN, STACIE  (contact);RENSLO, ADAM R

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Aftercare;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Amyloid beta-Protein;Amyloid beta-Protein Precursor;analog;Animal Model;Animals;Apoptosis;Award;Binding;Biochemical;Biological Assay;Biological Availability;Biological Markers;Brain;brain tissue;CASP6 gene;Caspase;Caspase Inhibitor;Cell Death;Cell model;Cells;Chemicals;Chronic;clinical candidate;Complex;Cysteine;Data;data modeling;design;Development;Disease;disease model;Disease Progression;Dose;Drug Kinetics;Drug or chemical Tissue Distribution;Environmental Risk Factor;Enzymes;experimental study;familial Alzheimer disease;Family;Fibrosis;Foundations;Funding;Future;Genetic;Goals;Half-Life;Hand;Hand functions;Harvest;Hour;Human;human model;improved;in vivo;Inflammation;inhibitor;Kinetics;Knock-out;Lead;lead optimization;Measurement;Measures;member;Metabolism;Modeling;mouse model;Mus;Mutation;nanomolar;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;Neurons;nonalcoholic steatohepatitis;novel;Oral;Patients;Penetrance;Penetration;Peptide Hydrolases;Perfusion;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology Study;Phase;phase 2 study;Phenotype;Plasma;presenilin;programs;Property;protein aggregation;Proteins;Proteolysis;Proteome;proteostasis;Resistance;Running;scaffold;Senile Plaques;Series;Serum;Small Business Technology Transfer Research;Structure;tau aggregation;tau Proteins;Therapeutic;Toxic effect;Work

PROJECT_TITLE: Optimizing brain penetrance of caspase-6 inhibitors to treat neurodegenerative diseases


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: Boulder

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF COLORADO

PHR: Public Health Relevance Statement Data-driven modeling methods are revolutionizing the modeling of complex systems and have proven to be incredibly successful at learning scientifically explainable and interpretable governing equations from data, yet are unreliable when applied to data with levels of noise and sparsity common to biomedical and biological data. My group has developed the Weak form Sparse Identification of Nonlinear Dynamics (WSINDy) method that has shown incredible promise in creating models and revealing mechanisms directly from data with substantial noise (in some cases at or above the 100% noise ratio level). The overarching goals of this research are to use the WSINDy method to investigate the 1) individual cell-based drivers for collective cell migration and 2) data-driven inference for unobserved processes in infectious disease dynamics as well as 3) extend WSINDy to infer stochastic dynamical systems and discover critical (but hidden) compartments.

PI_NAMEs: BORTZ, DAVID  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TITLE: Data-driven and science-informed methods for the discovery of biomedical mechanisms and processes

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Mental Health;Palliative Care;Prevention;Social Determinants of Health

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Patients with chronic obstructive pulmonary disease frequently experience psychological distress (i.e., depression and anxiety), which is associated with poor health outcomes and which patients, their caregivers, and clinicians have identified as the most critical palliative care need. This study will identify how an evidence- based coping skills training program, which partners patients and their caregivers to manage and overcome disease-related distress, reduces depression and anxiety among outpatients with chronic obstructive pulmonary disease. The findings will provide a better understanding of how social relationships affect patients’ psychological distress and will help health systems design and implement efficient strategies for patient- and family-centered palliative care within chronic illness care, particularly those affecting health disparities populations who experience inequities in access to such services.

PI_NAMEs: HART, JOANNA LEE (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: access disparities;Activities of Daily Living;Address;Adoption;Adult Children;Advisory Committees;Affect;Ambulatory Care Facilities;American;Anxiety;anxiety reduction;anxiety symptoms;arm;attentional control;Behavioral;behavioral health;Behavioral Sciences;Black race;Buffers;burden of chronic illness;care delivery;Caregiver support;Caregivers;Caring;Characteristics;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;Cognitive;cohesion;Collaborations;Communication;contextual factors;coping;Coping Skills;depressive symptoms;design;Disease;Distress;Dyspnea;Education;Educational process of instructing;Effectiveness;effectiveness testing;efficacious intervention;emotional symptom;Enrollment;evidence base;experience;Family;Family Caregiver;Family Relationship;Friends;Funding;future implementation;Gender;Health;Health behavior;Health Benefit;health disparity;health disparity populations;Health Promotion;health related quality of life;Health Services Accessibility;Health system;Healthcare;Heterogeneity;High Prevalence;implementation strategy;improved;improved outcome;Income;Individual;innovation;Intervention;Knowledge;Learning;Loneliness;Low income;Lung Diseases;Mediating;medication compliance;Mental Depression;Methodology;Methods;Modeling;National Heart, Lung, and Blood Institute;novel;Outcome;Outpatients;Palliative Care;Participant;Patient-Focused Outcomes;Patients;Pattern;Pennsylvania;persistent symptom;Personal Satisfaction;Physical Function;physical symptom;poor health outcome;Population;Positioning Attribute;prevent;Problem Solving;programs;psychoeducation;psychologic;psychological distress;Quality of life;Race;Randomized;randomized trial;randomized, clinical trials;recruit;remote delivery;Research Personnel;Resources;Respiratory Disease;Role;Rural Community;rurality;Self Efficacy;Services;skills;skills training;smoking cessation;social;Social Functioning;social relationships;Specialist;Stress and Coping;stressor;study population;Subgroup;success;Supportive care;Techniques;Telephone;Testing;theories;Training Programs;treatment as usual;treatment effect;trial comparing;Universities;uptake;Work

PROJECT_TITLE: Leveraging the dyad: mechanisms of an intervention for psychological distress in chronic lung disease

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Genetics;Human Genome;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Cells must inherit the right number of chromosomes every time they divide. Defects in this process are the most common chromosomal abnormality in cancer cells and contribute to birth defects and other diseases. We are therefore studying the process of chromosome distribution to daughter cells when they divide to understand the basis for a number of human diseases.

PI_NAMEs: BIGGINS, SUSAN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Aneuploidy;Biochemical;cancer cell;Cell Cycle;Cell Cycle Regulation;Cell division;Cells;Centromere;Chromosome abnormality;Chromosome Segregation;Chromosomes;Congenital Abnormality;Cytology;daughter cell;Defect;Development;Disease;Ensure;Eukaryota;Evolution;Genetic;Genome Stability;Human;human disease;in vitro Assay;Inherited;Kinetochores;Lead;Malignant Neoplasms;Microtubules;Organism;prevent;Process;Proteins;Saccharomycetales;Spontaneous abortion;Time;Weight-Bearing state;Work;Yeasts

PROJECT_TITLE: Mechanisms underlying chromosome segregation

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Narrative This study will develop resources to study patterns of somatic genomic alterations in pathologically normal human tissues. The landscape of somatic alterations in healthy tissues can help distinguish those more likely to be associated with aging and early disease progression, which has relevance for prevention and early detection of multiple types of diseases.

PI_NAMEs: DE, SUBHAJYOTI  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Affect;Aging;Autoimmunity;Back;Communities;Complex;course development;Development;Diagnosis;Disease;Disease Progression;disorder prevention;DNA biosynthesis;DNA Repair;DNA Sequence Alteration;Early Diagnosis;Etiology;Genetic;Genetic Variation;genome resource;genomic variation;Genomics;Hematopoiesis;Human;human tissue;Immune System Diseases;Lead;Malignant Neoplasms;mosaic;Nervous System Disorder;non-genetic;Normal tissue morphology;Organ;Pathologic;Pattern;Phenotype;Pigmentation physiologic function;Prevalence;Prevention;Regenerative capacity;Replication Error;Reproducibility;Research;Resolution;Resource Sharing;Resources;Somatic Cell;Somatic Mutation;Technology;technology development;Tissues;transcriptomics;Variant;zygote

PROJECT_TITLE: Computational genomic analysis of genomic variations in human tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Clinical Research;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project narrative This project will create knowledge resources about human anatomy that will combine textual, logical, and visual representations. These are designed to be understood by both computers and people. This work will enable clinical, research, and educational software applications to use information about human anatomy. 1

PI_NAMEs: CLARKSON, MELISSA  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Affect;Anatomic Models;Anatomy;base;biomedical ontology;Biomedical Research;Body System;Clinical;clinical application;Clinical Medicine;Communication;Communities;computable knowledge;computational anatomy;computational reasoning;Computer software;Computers;data integration;data modeling;Data Science;Data Set;design;Development;Disease;Education;Human;human model;Human Resources;Informatics;Information Resources;Information Systems;Knowledge;knowledgebase;Libraries;Medical Illustration;medical information system;Medicine;Modeling;Modernization;multidisciplinary;Names;next generation;Ontology;ontology development;Patient Care;Patients;Pattern;Persons;Positioning Attribute;preservation;Production;Readability;Recording of previous events;Research;Research Personnel;Resources;Scheme;Semantics;skills;Source;Standardization;Structure;Text;Time;trustworthiness;Variant;Visual;web app;Work

PROJECT_TITLE: Representing Human Anatomy for Computation and Communication: Synergistic Development of an Anatomical Ontology and Semantically-Augmented Anatomical Graphics

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics

ORG_DEPT: PHYSIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE The packaging and organization of eukaryotic genomic DNA into nucleosome units provides a rich layer of physical characteristics and interactions that constitute an important feature governing the activity of many chromatin regulators in the nucleus. Leveraging single-molecule visualization and manipulation methods, this project aims to dissect how the physical topology of nucleosomes regulates the function of pioneer transcription factors, chromatin-modifying enzymes, and energy-consuming molecular machines in real time and at high resolution. Our studies will uncover how nucleosomes biophysically modulate the interaction between chromatin and its regulators and may reveal mutation-selective protein-chromatin interfaces linked to pathogenesis that are vulnerable to chemical intervention for treating disease.

PI_NAMEs: LIU, SHIXIN  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Architecture;Atomic Force Microscopy;ATP phosphohydrolase;Base Pairing;Binding;Biological Assay;biophysical properties;Biophysics;Cell Nucleus;Characteristics;Chemicals;Chromatin;chromatin protein;Complex;Data;Detection;Disease;DNA;DNA Binding;DNA Packaging;Energy consumption;Enzymes;Exhibits;Fluorescence;Fluorescence Microscopy;Gene Expression;Genetic Transcription;Genome;Genomic DNA;Genomics;Geometry;helicase;Heterochromatin;Histone H1;Histone H2A;Histone H3;Histones;Human;human disease;Individual;Intervention;Investigation;Kinetics;Laboratories;Length;Licensing;Link;Linker DNA;Lysine;Measures;Methods;Methylation;Modification;Molecular Machines;Multienzyme Complexes;mutant;Mutation;Nucleosome Core Particle;Nucleosomes;Oncogenic;ORC1L gene;origin recognition complex;Pathogenesis;Polycomb;Positioning Attribute;Preparation;protein function;Proteins;recruit;Replication Initiation;Replication Origin;Reporting;Resolution;Role;Shapes;single molecule;Site;Spectrum Analysis;Technology;Testing;Therapeutic;Time;transcription factor;Variant;Visualization

PROJECT_TITLE: Biophysical Determinants of the Nucleosome as an Activity Center for Chromatin Regulators

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: CHAMPAIGN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative A number of molecular and cellular mechanisms have been linked to autism spectrum disorder (ASD), but how these mechanisms lead to the behavioral phenotypes that define autism remains largely unknown. Sensory processing deficits are one the most prevalent and debilitating features of autism that also provide a window into how brain function is altered in ASD more generally. This study will use the auditory system to examine sensory circuit disruptions in two rat models of ASD— the Fmr1KO rat model of Fragile X Syndrome and the Tsc2+/- Eker rat model of Tuberous Sclerosis Complex— in order to determine how the distinct cellular and molecular consequences of Fmr1 and Tsc2 mutation manifest at the neural circuit level to ultimately drive clinically-important behavioral phenotypes in ASD.

PI_NAMEs: AUERBACH, BENJAMIN D (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Address;Affect;Animals;Antibiotics;Auditory;Auditory area;Auditory Perception;Auditory Perceptual Disorders;auditory processing;Auditory system;autism spectrum disorder;autism symptoms;Behavior;Behavioral;behavioral phenotyping;Behavioral Symptoms;Biological Assay;Biological Models;Brain;cell type;Clinical;Clinical Trials;communication behavior;Complex;density;Development;Disabling;Disease;DNA Sequence Alteration;Electrophysiology (science);Equilibrium;Exhibits;Extracellular Matrix Proteins;FDA approved;Foundations;Fragile X Syndrome;FRAP1 gene;Functional disorder;Genetic;Hippocampus;Human Genetics;Hypersensitivity;Impairment;in vivo;information processing;innovation;Interneuron function;Interneurons;Intervention;Label;Lead;lens;Link;Maps;Memory;Metabolic;Minocycline;model of autism spectrum disorder;Modeling;Molecular;Molecular Profiling;mouse model;Mus;mutant;Mutation;Nature;neural circuit;Neuroanatomy;Neurocognitive;Neuronal Dysfunction;Neurons;neurophysiology;neuropsychiatry;next generation;novel;novel therapeutics;optogenetics;Parvalbumins;Pathogenesis;Pathway interactions;pharmacologic;Phenotype;Physiological;prevent;programs;Protein Biosynthesis;Rattus;Recurrence;Research;Risk Factors;Rodent Model;Sclerosis;Sensory;Sensory impairment;sensory system;Signal Transduction;skills;Social Behavior;sound;Symptoms;Synapses;synaptic inhibition;Techniques;Testing;tool;Training;treatment strategy;Tuberous Sclerosis

PROJECT_TITLE: Identifying Convergent Circuit Disruptions Across Genetically-Distinct Models of Autism

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Emergency Care;Health Services

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Although not ideal, emergency department use for non-traumatic dental conditions is common and results in unnecessary antibiotic and opioid prescribing. This project seeks to understand barriers and facilitators to appropriate non-traumatic dental condition management in the emergency department through quantitative and qualitative methods and pilot tests an intervention strategy to improve emergency department provider’s prescribing of antibiotics and opioids for non-traumatic dental conditions. Findings from this project will provide preliminary data to support a clinical trial to demonstrate the effectiveness of our intervention as a model to implement nationally to improve management of non-traumatic dental conditions in the emergency department and other health care settings.

PI_NAMEs: KHOUJA, TUMADER  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Acute;Adult;Allergic Reaction;Antibiotics;Area;Award;bacterial resistance;Behavior Therapy;Behavioral;biomedical informatics;career;Caring;clinical decision support;Clinical Trials;Clostridium difficile;cohort;Data;Data Set;Dental;Dental Care;Dentists;design;Development;Diagnosis;Doctor of Philosophy;Education;Educational Curriculum;Effectiveness;Effectiveness of Interventions;effectiveness testing;Electronic Health Record;Emergency Care;Emergency Department Physician;Emergency department visit;Endodontics;Ensure;Evidence based intervention;experience;Fostering;Goals;Guidelines;Health;health care settings;Health Services;Health system;Hospitalization;Hospitals;Hour;human centered design;improved;indexing;Individual;Infection;Inflammation;Insurance;Intervention;Interview;Knowledge;Life;Medicaid;Medical;Medical center;Medicare;Mentorship;Methods;Minority;Mission;Modeling;Myocardial Infarction;National Institute of Dental and Craniofacial Research;Nurse Practitioners;Opioid;opioid use;Oral health;Pain management;Palliative Care;Pathway interactions;Patient Care;Patients;Persons;Pharmacists;Physician Assistants;Physicians;pilot test;prescription opioid;Preventive dental care;programs;Provider;Psychologist;Public Health;Qualitative Methods;Research;Research Methodology;Research Personnel;Rural;Science;Scientist;Serious Adverse Event;skills;Smiling;Source;success;support tools;Surgeon;symposium;System;Talents;Testing;tool;Toothache;Training;Uninsured;United States National Institutes of Health;Universities;urgent care;Variant;Visit;Work

PROJECT_TITLE: Development of a provider centered intervention for Non-Traumatic Dental Condition management in the Emergency Department

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative Transgender adults experience disproportionately high rates of tobacco use compared to the U.S. general adult population. Despite the role health care providers can play in cessation, transgender adults report barriers to accessing evidence-based, clinician-delivered interventions. This research will be foundational in the development of a transgender-specific health services resource for health care providers who might not have the time or expertise to provide gender affirming smoking cessation support to their transgender patients.

PI_NAMEs: SUN, CHRISTINA JIAYI (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Academy;acceptability and feasibility;Address;Adult;Affect;Alcohol consumption;Behavior;Biological Markers;burden of illness;Carbon Monoxide;cardiovascular risk factor;Caring;Cessation Research;cigarette smoke;cigarette smoking;Climacteric;Collaborations;cost effective;Cotinine;Data;Data Collection;design;Development;Disparity;Drug usage;Effectiveness;Effectiveness of Interventions;effectiveness testing;effectiveness trial;Ensure;Event;evidence base;Evidence based intervention;experience;Feedback;Future;gender affirmation;gender affirming care;gender affirming medical care;gender minority;gender minority health;Health;health disparity;health disparity populations;health economics;Health Personnel;Health Resources;Health Services;Health Services Research;Health system;hormone therapy;improved;Intervention;Interview;Knowledge;Location;Measures;Medical;Medicine;Mental Health;mHealth;mhealth interventions;mobile computing;Modeling;Monitor;multidisciplinary;Myocardial Infarction;National Institute of Drug Abuse;Operative Surgical Procedures;Outcome;Participant;Patient Self-Report;Patients;peer;person centered;Persons;physical conditioning;pilot test;pilot trial;Play;Population;primary outcome;Process;Protocols documentation;Provider;Randomized;Randomized, Controlled Trials;Reporting;Research;retention rate;Risk;Role;Sampling;scale up;Science;secondary outcome;Sexual and Gender Minorities;Smoke;Smoking;smoking cessation;Smoking Cessation Intervention;Social support;Stroke;success;Surgeon;surgery outcome;tailored messaging;Technology;Testing;therapy design;therapy outcome;Time;Tobacco;tobacco cessation intervention;tobacco control;Tobacco use;Tobacco Use Cessation;Tobacco Use Disorder;tool;transgender;transgender women;transphobia;treatment as usual;United States National Institutes of Health;usability;venous thromboembolism;wound healing

PROJECT_TITLE: Proud to Quit (P2Q): A Person-centered mobile technology intervention for smoking cessation among transgender adults

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: LEVY, DAVID THEODORE;MENDEZ EMILIEN, DAVID  (contact);MEZA, RAFAEL

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: tobacco regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-R]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: Immune therapies have resulted in prolonged survival for patients with various types of cancer, and are changing the landscape for cancer research and cancer care. Many of the major advances were led by scientists and clinical researchers at Yale School of Medicine. We propose to continue to capitalize on this expertise as well as the rich resources available at Yale to train the next generation of Cancer Immunologists and Immunotherapists capable of conducting translational research to advance patient care.

PI_NAMEs: KLUGER, HARRIET M. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acceleration;Address;Adjuvant;Appointment;Area;Biology;cancer immunotherapy;cancer research center director;cancer type;Cell Therapy;Clinical;clinical center;clinical investigation;Clinical Research;Clinical Trials Design;clinically relevant;community engagement;Community Outreach;curriculum development;Doctor of Philosophy;Drug Combinations;Drug toxicity;Eligibility Determination;Enrollment;Faculty;Funding;gateway course;Grant;Home;Immunobiology;Immunology;immunomodulatory therapies;Immunooncology;Immunosuppression;Immunotherapy;Individual;Institution;Laboratory Research;medical schools;Mentors;Mentorship;Oncology;patient oriented;patient oriented research;Play;pre-clinical;programs;Records;Research;Research Personnel;Research Project Grants;Resistance;response;synergism;Time;Training;Training and Education;Training Programs;translational immunology;Translational Research;trial design;tumor immunology;tumor microenvironment;Yale Cancer Center

PROJECT_TITLE: YALE CANCER CENTER CALABRESI IMMUNO-ONCOLOGY TRAINING PROGRAM

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Nuclear Hormone Receptors (NRs) are a structurally related family of transcription factors that are valuable targets in inflammation and cancer therapies. This proposal seeks to better understand a common ubiquitin- proteasome dependent degradation mechanism governing NRs and its role in transcriptional regulation. The long-term goal is to interrogate the relationship between and decouple hormone induced NR activation and degradation; we will first conduct basic research in biochemistry to understand the interactions between E3 ligases and NRs, and test the feasibility of this overall approach in cellular models.

PI_NAMEs: TSAI, JONATHAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Affect;Androgen Receptor;Androgens;Area;Basic Science;Binding;Biochemical;Biochemistry;Biology;Board Certification;Boston;Breast;cancer cell;cancer therapy;career;Cell model;Cell Survival;cholesterol trafficking;Chromatin;Clinical;Clinical Pathology;clinical training;Cryoelectron Microscopy;Dedications;Degradation Pathway;Development;dimer;Disease;Doctor of Philosophy;Drug Design;Drug Prescriptions;Drug Targeting;Electron Microscopy;Environment;Equipment;Estrogen Receptors;Estrogens;experience;Failure;Family;feasibility testing;Feedback;Fellowship;Fibrosis;Flow Cytometry;Foundations;Genetic Transcription;Glucocorticoid Receptor;Glucocorticoids;Goals;graduate student;Health;Hematopoietic stem cells;hormonal signals;Hormone Receptor;Hormones;Hospitals;Hydrophobicity;Inflammation;innovation;insight;Institution;interest;Investigation;Laboratories;Libraries;Ligand Binding;Ligands;Liver X Receptor;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Spectrum Analysis;Medical;Mentors;Molecular;Molecular Genetics;monomer;multicatalytic endopeptidase complex;Mutation Analysis;next generation sequencing;novel strategies;Nuclear;Nuclear Hormone Receptors;Orphan;Pathology;Pathway interactions;Physiological;Process;Progesterone;programs;Prostate;protein degradation;Protein Hormone Receptor;Proteins;rational design;receptor;Receptor Activation;receptor binding;Receptor Signaling;recruit;Regulation;Research;Resources;Retinoic Acid Receptor;Retinoids;Role;Sampling;Selective Estrogen Receptor Modulators;Services;Signal Transduction;Site;skills;small molecule;success;Therapeutic;therapeutic target;Thyroid Gland;Tissues;transcription factor;Transcriptional Activation;Transcriptional Regulation;Ubiquitin;ubiquitin-protein ligase;undergraduate student;Woman;Work

PROJECT_TITLE: Characterizing a Common Degradation Pathway for Nuclear Hormone Receptors


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Machine Learning and Artificial Intelligence;Nanotechnology

ORG_CITY: DALLAS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: SOUTHERN METHODIST UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE We propose to develop a nanomedicine sensor that is capable of determining the genetic content of manufactured viruses with a high degree of accuracy. Current virus content analysis methods are unable to consistently and accurately determine if viruses intended for gene therapy contain their full genetic cargo or not, and as a result, under- or over-dosing remains a critical problem in viral gene therapy. Additionally, current analytical methods require using large amounts of the virus preparation for quality control, which is costly and wasteful; our proposed sensor requires only minute (pico- to nano-molar concentrations) virus amounts.

PI_NAMEs: KIM, MINJUN  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;analytical method;Attention;Back;Biological;blind;Buffers;Capsid;Charge;Classification;Complex;cost;Data;deep neural network;Dependovirus;Deposition;Diameter;Discrimination;Disease;Dose;Drops;Drug Delivery Systems;ds-DNA;Effectiveness;electrical potential;Electrolytes;Electrophoresis;Encapsulated;Enzyme-Linked Immunosorbent Assay;Exclusion;experimental study;FDA approved;Gene Delivery;Gene Dosage;gene therapy;Genes;Genetic;Genetic Materials;Geometry;Gold;hereditary blindness;Hybrids;improved;Ions;Label;Length;Light;Machine Learning;machine learning classification;machine learning framework;machine learning model;manufacture;Measurement;Measures;Membrane;Methods;Modality;Motion;multimodality;nano;nanomedicine;nanomolar;nanoparticle;nanopore;nanosensors;neural network;optic trap;optical traps;Optics;Outcome;Overdose;particle;personalized medicine;plasmonics;Polystyrenes;Population;Preparation;Probability;Protocols documentation;quality assurance;Quality Control;Reproducibility;Resolution;Sampling;sensor;Shapes;Signal Transduction;Single-Stranded DNA;solid state;sound;Structure;Surface;System;Techniques;Technology;Testing;Theoretical model;Therapeutic;Thinness;Training;transfer learning;transmission process;trend;Uncertainty;vector;Viral;viral detection;Viral Genes;Virion;Virus;virus classification;voltage

PROJECT_TITLE: Multimodal Label-Free Nanosensor for Single Virus Characterization and Content Analysis

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The gap junctions are a class of membrane channel proteins that form direct pathways for cell-to-cell communication. Dynamic mechanisms of channel gating are required to control these communication pathways, while their misregulation is associated with a range of pathophysiological conditions, including blindness, deafness, cardiac arrhythmia, stroke and cancers. Our research group is using methods in high- resolution imaging by electron cryo-microscopy (CryoEM) to understand the detailed mechanisms of gap junction regulation and how aberrant regulation of inter-cellular communication manifests in disease.

PI_NAMEs: REICHOW, STEPHEN LOEN (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Address;Architecture;Arrhythmia;Biological Phenomena;Biophysics;Blindness;Brain;Cell Communication;Cells;Chemicals;Communication;Complex;Computer Models;Coupled;Cryoelectron Microscopy;deafness;Development;Disease;Environment;Gap Junctions;Hand;Heart;high resolution imaging;Imaging technology;in situ imaging;intercellular communication;Investigation;Ion Channel;Knowledge;Light;Lipids;Malignant Neoplasms;Mediator;Medical;Membrane Proteins;Methods;Molecular;Pathway interactions;pharmacologic;Physiological;Protein Biochemistry;Protein Structure Databases;Proteins;Regulation;Research;Resolution;Signal Transduction;Smell Perception;sound;Stroke;Structure;targeted treatment;Taste Perception;tool;Touch sensation

PROJECT_TITLE: Dynamic Mechanisms of Membrane Channel Gating by CryoEM


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Neurosciences;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Program Director/Principal Investigator (Last, First, Middle): Dix, Richard D Project Narrative The proposed project is relevant to public health because its performance will demonstrate for the first time that intraocular stimulation of multiple cell death pathways through different mechanisms contribute to the severe retinal disease pathology and loss of function that develops during pathogenesis of AIDS-related HCMV retinitis. The project is relevant to the NEI mission because its performance could lead to new therapeutic approaches to lessen vision loss and blindness associated with HCMV retinitis during AIDS and other forms of immunosuppression through use of cell death pathways inhibitors. This novel therapeutic approach could extend to other retinal diseases of herpesvirus origin in immunologically normal persons. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: DIX, RICHARD D (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Apoptosis;Blindness;Cell Death;cell type;Cells;Cytomegalovirus;Cytomegalovirus Retinitis;Development;Diagnosis;Eye;Eye diseases;Frequencies;Goals;Herpesviridae;HIV;Human;Immunologics;Immunosuppression;In Vitro;Individual;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Infiltrate;inhibitor;Invaded;Knowledge;Lead;loss of function;Mediating;Messenger RNA;Mission;mouse model;Murid herpesvirus 1;Mus;mutant;Natural Immunity;novel therapeutic intervention;Onset of illness;Outcome;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;Performance;Persons;Play;Predisposition;prevent;Principal Investigator;programs;Protein Kinase Interaction;Proteins;Public Health;Receptor-Interacting Protein;recruit;Research;Retina;Retinal Diseases;Retinitis;Retroviridae;Role;Severities;Testing;Time;Tissues;Virus;virus development;Virus Diseases;Vision;Z-DNA Binding Protein

PROJECT_TITLE: Programmed cell death and cytomegalovirus retinitis pathogenesis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Antimicrobial resistance (AMR) among Gram-negative rod organisms is one of the most urgent public health threats in the United States and globally. By using series of survey of clinicians, retrospective cohort analyses, and machine learning prediction analytics, this study elucidates the current perceptions for AMR among providers and creates a machine learning model to accurately predict AMR risk at patient-level. The findings from this study will help create a decision-support system to guide clinicians for appropriate empiric therapy to treat infections due to Gram-negative rod organisms and prepare the applicant for a career as an independent infectious diseases health service investigator.

PI_NAMEs: GOTO, MICHIHIKO  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Improving Empiric Antimicrobial Therapy for Gram-Negative Infections through a Personalized Smart Antibiogram

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Individuals with intellectual and developmental disabilities (IDD) have poor health outcomes, and their life expectancy is 20 years shorter than the rest of the U.S. population. The limited arsenal of efficacious treatments for these disorders exacerbates this public health emergency. This proposal will develop a framework for identifying convergent mechanisms for a group of IDD risk genes, which would accelerate the development of mechanism-based therapies.

PI_NAMEs: DHINDSA, RYAN  (contact)

PROJECT_TERMS: Acceleration;Affect;Binding Sites;Biological;Calcium;career;Chromatin;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;Collaborations;college;Complex;Computing Methodologies;Confounding Factors (Epidemiology);CRISPR interference;Development;developmental disease;disabled;Disease;disease model;DNA-Binding Proteins;efficacious treatment;Electrophysiology (science);empowerment;Epigenetic Process;epigenomics;experimental study;Family;Family member;Financial Support;Foundations;functional genomics;Funding;Gene Expression;Genes;Genetic;Genetic Transcription;Genomics;graduate student;Grant;histone demethylase;histone modification;Human;Human Genetics;Image;Individual;individualized medicine;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;inhibitor;Institution;Intellectual functioning disability;Journals;knock-down;Life Expectancy;Maps;Medicine;Mentors;Mentorship;method development;Methylation;Methyltransferase;MLL gene;Modeling;Morphology;multi-electrode arrays;National Research Service Awards;Neurodevelopmental Disorder;Neurologic;Neurons;novel;Paper;Pathway interactions;Patients;Pediatric Hospitals;Phenotype;poor health outcome;Population;Productivity;programs;protein complex;Proteins;public health emergency;Publishing;Research;Research Institute;Research Personnel;Research Training;Resources;Rest;risk variant;single-cell RNA sequencing;small molecule;stem cell biology;stem cells;Subgroup;System;Testing;Texas;Therapeutic;Therapeutic Intervention;Training;transcriptomics;Vision;Work

PROJECT_TITLE: Identifying transcriptomic and epigenomic convergence in intellectual and developmental disorders