ED_INST_TYPE: SCHOOLS OF EDUCATION

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE There is an urgent need to understand how adolescents can effectively manage their social media use in the face of simultaneous precipitous rises in mental health problems and social media use among U.S. adolescents. This innovative study will use rigorous measurements of social media management strategies, actual social media use, and mental health outcomes with a longitudinal mixed-method design. The study will provide much-needed scientific data to understand the effects of social media on adolescents' mental health and lay a solid foundation for the development of well-received, effective interventions to reduce the risks of mental health problems related to social media use by adolescents.

PI_NAMEs: SUN, XIAORAN  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adolescence;Adolescent;adolescent mental health;Adopted;Affect;Age;aged;Aggressive behavior;Algorithms;Anxiety;Awareness;Baseline Surveys;Cellular Phone;Characteristics;Computer Vision Systems;computerized data processing;Data;Data Collection;deep learning;design;Development;diaries;digital;effective intervention;Equation;ethnic diversity;Ethnic Origin;feasibility testing;follow-up;Foundations;Gender;Goals;Harm Reduction;Health Surveys;Image;implementation strategy;implementation tool;improved;innovation;Institutional Review Boards;Intervention;intervention program;Interview;Knowledge;Label;lens;Link;Longitudinal Studies;Measurement;Measures;media use;Mental Depression;Mental Health;Metadata;Methods;Modeling;Outcome;Parents;Participant;Patient Self-Report;peer;Personal Satisfaction;Phase;phase 2 designs;Pilot Projects;Policy Maker;Procedures;Process;Race;racial diversity;recruit;Reporting;Research;response;Risk;risk minimization;Sampling;Schools;Seasons;Secure;social;social media;Solid;Source;Structure;Surveys;Technology;Telephone;Testing;Text;Time;tool;Training;trend;Work

PROJECT_TITLE: Adolescents' Social Media Management Strategies: Bidirectional Links to Objective Social Media Use and Mental Health Outcomes


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Serious Mental Illness;Substance Misuse

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This administrative supplement to DA058314, Development of practical screening tools to support targeted prevention of early, high-risk drinking substance use, will enhance public health by facilitating the creation of an open-source toolkit for developing practical screening instruments using ABCD Study data. Accurate screening instruments can help clinicians and scientists estimate risk, triage families, and allocate resources more efficiently.

PI_NAMEs: PELHAM III, WILLIAM ELLERBE (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Administrative Supplement;Age;Anxiety Disorders;Award;Chronic;Clinic;Code;Communities;Companions;Computer software;Consumption;Data;Development;Diagnosis;Drug usage;early adolescence;early onset;Environment;Equity;Evaluation;falls;Family;Family Relationship;high risk;high risk drinking;improved;instrument;interest;Knowledge;Major Depressive Disorder;Measures;member;Metadata;open source;open source tool;Outcome;Outcome Measure;Paper;parent project;peer;Peer Review;Performance;Phenotype;Policy Maker;preservation;Prevention;Process;prospective;Protocols documentation;Psychoses;Public Health;Publications;Publishing;Research;Research Personnel;Resource Allocation;Resources;Risk;Risk Estimate;risk prediction;Sample Size;Sampling;School Drop-Outs;Schools;Scientist;screening;Screening procedure;Student Dropouts;substance use;success;Suicide;Surveys;Time;tool;Triage;web site;webinar;Work;Youth


NIH_SPENDING_CATS: Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Natural Products;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project narrative A large fraction of people with HIV (PWH) also use cannabanoids (CBs), but the impact of CB exposure on the HIV reservoir in these individuals is unknown. CBs can modulate numerous cellular signal pathways that can impact HIV replication, and our hypothesis is that CB exposure alters gene expression and chromatin structure in CD4 T cells that are latently infected with HIV. The goal of this proposal is to define the impact of CBs on latently infected cells, and to correlate reservoir properties with CB-regulated transcriptional signatures.

PI_NAMEs: BROWNE, EDWARD P (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Anti-Inflammatory Agents;Biological Assay;Biological Models;Blood specimen;Cannabinoids;CD4 Positive T Lymphocytes;Cell model;Cells;Cellular Assay;Characteristics;Chromatin Structure;Chronic;Clinical;CNR2 gene;cohort;Collection;Data;data integration;Data Set;design;DNA;drug of abuse;epigenome;epigenomics;Gene Expression;Gene Expression Profile;Genetic Transcription;Genomics;Goals;HIV;HIV Infections;Immune;immunoregulation;In Vitro;in vivo;in vivo evaluation;Individual;insight;Investigation;latent HIV reservoir;Location;Maintenance;Methods;Modeling;Molecular;multiple omics;Nature;novel;Outcome;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Phase;Phenotype;Population;Property;Proviruses;reactivation from latency;Role;Sampling;Shapes;Signal Induction;Signal Pathway;Signal Transduction;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;T-Lymphocyte;Testing;Time;tool;Transcript;Transcription Factor AP-1;transcriptome;transcriptomics;Viral;Viral Genes;Viral reservoir

PROJECT_TITLE: Defining the impact of cannabinoids on the latent HIV reservoir through multi-omic analysis


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative This Diversity Supplement application will extend the aims of the parent grant by examining multi-level individual, cultural and social context factors that may be related to reach of family cascade screening for Familial Hypercholesterolemia (FH). Findings will fill gaps in knowledge about understudied factors contributing to inequities in family cascade screening among Black or African American people with FH. The career development plan outlined in this proposal will support the candidate’s career goal of becoming an independent investigator focused on improving health outcomes among Black or African American people.

PI_NAMEs: BEIDAS, RINAD SARY (contact);RADER, DANIEL JAMES;VOLPP, KEVIN G

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Affect;African American;African American population;Age;Asian;Asian Americans;Award;Behavior;behavioral economics;Belief;Black American;Black Populations;career;career development;Caring;cascade genetic testing;Communication;comparative effectiveness;contextual factors;Development;Development Plans;Diagnosis;Discrimination;Disparity;disparity gap;Doctor of Philosophy;doctoral student;Dominant Genetic Conditions;effectiveness/implementation hybrid;Enrollment;Equity;Evidence based practice;experience;Familial Hypercholesterolemia;Family;Family dynamics;Family member;Financial Hardship;Foundations;Future;Gender;Genetic Diseases;Goals;Health;Health behavior;health care quality;health equity;Health system;Hereditary Disease;Heritability;housing instability;implementation science;improved;Individual;Inequity;insight;Intervention;Interview;Knowledge;Lived experience;Measures;Medical;Mentors;Mentorship;Methods;minority communities;Minority Groups;National Heart, Lung, and Blood Institute;neighborhood safety;Outcome;Output;parent grant;Parents;Participant;Pathway interactions;Persons;Population;primary outcome;proband;programs;provider factors;racial identity;racial population;Randomized, Controlled Trials;Research;Research Personnel;Role;screening;Self Concept;Self Efficacy;skills;social determinants;Social Environment;social health determinants;Social support;structural determinants;Testing;Training;Transportation;United States;Voice;Woman;Work

PROJECT_TITLE: Leveraging behavioral economics to equitably implement cascade screening in individuals with familial hypercholesterolemia in partnership with the FH Foundation


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE HIV infects the brain, and can diminish cerebral health and cognitive function despite the availability of drugs effectively targeting viral replication. This fellowship will investigate whether HIV produces patterns of structural damage and dysfunction similar to increased aging by using machine learning to estimate brain-predicted age from magnetic resonance imaging. This approach will help us understand the origins of cognitive impairment in persons with HIV, and may enable better prognosis and clinical care for those at risk of cognitive decline.

PI_NAMEs: PETERSEN, KALEN J. (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acceleration;Address;Adherence;Age;age effect;Age-associated memory impairment;Aging;aging brain;aging related;antiretroviral therapy;Axon;Biological Markers;Biology;Brain;Brain imaging;Cardiovascular Diseases;cardiovascular risk factor;career;Caring;CD4 Lymphocyte Count;cerebral atrophy;Cerebrum;Chronology;Clinical;clinical care;clinical predictors;clinically relevant;Cognition;Cognitive deficits;cognitive function;Communicable Diseases;comorbidity;connectome;Data;Data Analytics;Dementia;Demyelinations;Development;Diffusion Magnetic Resonance Imaging;diffusion weighted;Disease;economic outcome;Education;Etiology;experience;Fellowship;Functional disorder;Functional Magnetic Resonance Imaging;Goals;gray matter;Health;HIV;Impaired cognition;improved;improved outcome;Individual;insight;Instruction;Knowledge;Learning;Life Expectancy;life span;lifestyle factors;Link;Machine Learning;Magnetic Resonance Imaging;Measures;Medical;Mentors;Mentorship;Modeling;mortality;multidisciplinary;multimodality;network dysfunction;neural;Neurocognitive;Neurocognitive Deficit;neuroimaging;Neurologic;Neuropathy;Neuropsychological Tests;Neuropsychology;Older Population;Outcome;outcome prediction;Participant;Pathologic;pathological aging;Pattern;Performance;Persons;Pharmaceutical Preparations;Population;Predictive Factor;preservation;Prevalence;Prognosis;Quality of life;Research;Research Personnel;resilience;Rest;Risk;Risk Factors;skills;socioeconomic disadvantage;Socioeconomic Factors;socioeconomics;statistics;Structure;Structure-Activity Relationship;Techniques;Testing;Training;Viral;Viral Load result;Virus Replication;Vulnerable Populations;Water Movements;white matter;White Matter Disease

PROJECT_TITLE: Brain aging and cognitive impairment in persons with HIV


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Telehealth

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE School-based behavioral approaches to managing challenging behaviors in children on the autism spectrum are limited by three key factors: 1) children on the autism spectrum often have difficulties communicating their emotions; 2) it is challenging to implement evidence-based, personalized strategies for individual children, and; 3) it is difficult for teachers to track which strategies are successful for individual children. Our proposed personalized mobile-health emotion regulation application will pair heart rate tracking with digital tools to help reduce challenging behavior by supporting stress detection, reminding teachers of specific behavioral strategies and helping teachers to track progress.

PI_NAMEs: NUSKE, HEATHER J (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Address;Administrator;Adoption;adult with autism spectrum disorder;affective neuroscience;Agreement;autism spectrum disorder;autistic children;Behavior;Behavioral;burnout;Case Study;Cellular Phone;Child;clinical decision support;Collaborations;Communication;Communication difficulty;community partners;community partnership;Data;design;Detection;Development;digital health;digital technology;digital tool;Discipline;Distress;Education;Effectiveness;effectiveness evaluation;emotion dysregulation;emotion regulation;Emotions;Evaluation;evidence base;Evidence based practice;Exhibits;experience;Family;follow-up;Foundations;Future;Health;Heart Rate;Hospitalization;implementation science;implementation strategy;improved;indexing;Individual;individuals with autism spectrum disorder;Intervention;Interview;Measurement;Measures;meetings;mHealth;Mobile Health Application;Movement;Notification;novel;Outcome;Parents;Personal Satisfaction;personalized medicine;personalized strategies;Philadelphia;Physiological;Pilot Projects;pilot test;prevent;prototype;Psychophysiology;Randomized;Reporting;Research;Research Personnel;Sampling;school district;School-Age Population;Schools;Sensory;showing emotion;Signal Transduction;Specificity;Strategic Planning;Stress;stress management;stress reduction;Structure;Students;Surface;teacher;Technology;technology intervention;Testing;Time;tool;Training;usability;Waiting Lists;Work

PROJECT_TITLE: Reducing Challenging Behaviors In Children With Autism Through Digital Health


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Newark

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative Temporomandibular (jaw) joint osteoarthritis can cause severe chronic neuropathic pain that can negatively impact quality of life. We are using a multi-omic approach using single-cell RNAseq and state-of-the-art spatial proteomics to map the immune and neural underpinnings of changes driven by osteoarthritis in the jaw joint. This application uses a cross-disciplinary strategy to tackle a substantial public health concern - jaw joint damage and pain associated with aging - that aligns well with the musculoskeletal focus of the parent COBRE grant and provides a foundation to develop a strong collaborative program to develop strategies for chronic pain treatment.

PI_NAMEs: ELLIOTT, DAWN M (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Address;Afferent Neurons;age group;Age Months;Aging;Anatomy;Animals;Arthralgia;Articular Range of Motion;Atlases;Automobile Driving;Axon;Biological;Biology;Cells;Centers of Research Excellence;Chronic;chronic neuropathic pain;chronic pain;chronic pain management;Clinical;cohort;Collaborations;Complex;Cytometry;Data;debilitating pain;Degenerative Disorder;Degenerative polyarthritis;Delaware;Disease;Elements;Etiology;Evaluation;Evidence based treatment;Exposure to;Female;Foundations;Functional disorder;Future;Genetic;Genetic Models;Grant;Headache;Health;Hypersensitivity;Image;imaging platform;Immune;Immune response;Impairment;improved;Individual;Inflammation;Inflammatory;Injury;insight;Jaw;joint destruction;joint injury;Joints;Knowledge;Lead;Libido;male;Maps;Molecular;Molecular Profiling;mouse model;multidisciplinary;multiple omics;Mus;Musculoskeletal;Nature;nerve supply;neural;Neurobiology;Neurons;Neuropathy;new therapeutic target;novel;Pain;pain processing;painful neuropathy;parent grant;parent project;Parents;Pathogenesis;Patients;Peripheral;Play;Population;Pre-Clinical Model;Prevalence;programs;Proteins;Proteomics;Public Health;Quality of life;Research;Research Design;Resolution;Resources;Risk;Sampling;Science;Sensory;sex;Sex Differences;sexual dimorphism;Signaling Protein;single-cell RNA sequencing;Speed;Structure;Structure of trigeminal ganglion;System;technological innovation;Technology;Temporomandibular Joint;Temporomandibular Joint Disorders;Temporomandibular joint osteoarthritis;Testing;therapeutic candidate;Therapeutic Intervention;Time;Tissue imaging;Tissues;Tracer;transcriptomics;Translating;Woman;Women's Health

PROJECT_TITLE: Delaware Center for Musculoskeletal Research


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases

PHR: PROJECT NARRATIVE Laryngeal symptoms suspected to be from laryngopharyngeal reflux (LPR) are prevalent, heterogeneous and in critical need of personalized care approaches. The double-blind randomized placebo-controlled MVP trial will compare efficacy between a mechanism guided strategy versus usual care empiric proton pump inhibitor strategy for adult patients with chronic laryngeal symptoms undergoing evaluation for LPR. This proposal will determine efficacy of a mechanism guided strategy leveraging the innovative laryngeal recalibration therapy and examine performance of cutting-edge tools to identify an optimal diagnostic strategy for LPR in order to disrupt usual care and discover a novel mechanism guided paradigm for LPR.

PI_NAMEs: YADLAPATI, RENA HIREN (contact)

PROGRAM_OFFICER_NAME: KLAPPROTH, JAN-MICHAEL AXEL

PROJECT_TERMS: Acids;active control;Address;Adoption;Adult;Anxiety;Attenuated;Awareness;Behavior;Behavior Therapy;Behavioral Model;Bile Acids;Biological Markers;Blinded;Calibration;Caring;Characteristics;Chronic;Clinical;Clinical Trials;Cognitive;cognitive enhancement;comparative efficacy;Consultations;Coughing;Counseling;Data;design;Diagnosis;Diagnostic;Diagnostic Procedure;diagnostic strategy;Diagnostic tests;digital;Double-Blind Method;efficacy evaluation;Endoscopy;Ensure;Esophagus;Esthesia;Evaluation;experience;Functional disorder;Future;Gastric Acid;Gastroesophageal reflux disease;Goals;habituation;Health Care Costs;Impairment;improved;indexing;Individual;inhibitor;inhibitor therapy;innovation;Investigation;Irritants;laryngopharyngeal reflux;Larynx;Light;Mechanics;Mediating;Monitor;multidisciplinary;novel;Office Visits;Outcomes Research;Patients;Pepsin A;Performance;personalized care;Pharyngeal structure;Physiology;Placebo Control;Placebos;Positioning Attribute;Practice Guidelines;primary outcome;programs;Proton Pump Inhibitors;Pump;Quality of life;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Recommendation;Reflux;response;risk prediction;Role;Salivary;Symptom Burden;Symptoms;Testing;Therapeutic;Time;tool;treatment as usual;treatment strategy;Voice;Voice Quality;Work

PROJECT_TITLE: The MVP Trial: A Randomized Controlled Trial of Mechanism Guided vs PPI Strategy for Laryngopharyngeal Reflux

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: SAINT PAUL

ORG_NAME: THE BEAUTYWELL PROJECT

PHR: Project Narrative We propose expanding the culturally responsive content we have been creating and the community-based education to address skin-lightening practices and chemical exposures. Grounded in community participatory approaches.

PI_NAMEs: ADAWE, AMIRA  (contact)

PROGRAM_OFFICER_NAME: ABBADI, SOAD

PROJECT_TITLE: Expanding the Public Awareness of Skin-lightening Practices and Chemical Exposure and Creating a Framework that Advances the Wellbeing of Impacted Communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 OC-T (04)]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Services;Social Determinants of Health;Women's Health Research

ORG_CITY: SILVER SPRING

ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

ORG_STATE: MD

PI_NAMEs: NARANJO, REENA  (contact)

PROJECT_TERMS: Awareness;Clinical Research;community engagement;Contractor;Contracts;Data;Data Analytics;data management;Educational workshop;Evaluation;Event;Grant;health communication;health literacy;Human;Literacy Programs;Manuscripts;meetings;National Institute of Environmental Health Sciences;Persons;Preparation;Questionnaires;Research;Research Activity;Research Support;Services;Surveys;symposium;virtual;webinar;Women's Health

PROJECT_TITLE: CONTRACT NO.: HHSN273201600002I - CLINICAL RESEARCH SUPPORT SERVICES FOR NIEHS


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: BRISCOE, LYNN  (contact)

PROJECT_TITLE: FY20 CONSOLIDATED FACILITIES TASK ORDER D


NIH_SPENDING_CATS: Biotechnology;Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: INTEGRATED LABORATORY SYSTEMS, LLC

PI_NAMEs: ALLEN, DAVID  (contact)

PROJECT_TERMS: adverse outcome;Animals;Authorization documentation;base;Characteristics;Chemicals;Contractor;Contracts;Data;Databases;Development;diverse data;Documentation;Economics;Educational workshop;Ensure;Evaluation;flexibility;Guidelines;Hazard Identification;Health;high throughput screening;Human;in silico;In Vitro;in vivo;information gathering;Interagency Coordinating Committee on the Validation of Alternative Methods;interest;Knowledge;Literature;meetings;Methods;Mission;Modeling;National Toxicology Program;novel;Pathway interactions;Peer Review;Performance;pharmacodynamic model;physiologically based pharmacokinetics;Production;Published Comment;Publishing;Quantitative Structure-Activity Relationship;Reporting;Research;research and development;Research Support;Risk Assessment;safety testing;screening;Support Contracts;System;Testing;text searching;Toxicokinetics;Toxicology;Validation;validation studies;Work;Writing

PROJECT_TITLE: NICEATM Support Contract: Base Contract


PROJECT_TERMS: adverse outcome;Animals;Area;Authorization documentation;Characteristics;Chemicals;Contractor;Contracts;Data;Databases;Development;diverse data;Documentation;Economics;Educational workshop;Ensure;Evaluation;flexibility;Guidelines;Hazard Identification;Health;high throughput screening;Human;in silico;In Vitro;in vivo;information gathering;Interagency Coordinating Committee on the Validation of Alternative Methods;interest;International;Knowledge;Letters;Literature;meetings;member;Methods;Mission;Modeling;Molecular;National Toxicology Program;novel;outreach;Pathway interactions;Peer Review;Performance;pharmacodynamic model;physiologically based pharmacokinetics;Production;Published Comment;Publishing;Quantitative Structure-Activity Relationship;Reporting;Research;research and development;Research Support;Risk Assessment;safety testing;screening;Support Contracts;System;Testing;text searching;Toxicokinetics;Toxicology;Travel;Validation;validation studies;web page;Work;Writing

PROJECT_TITLE: NICEATM Support Contract: Meeting Support and Contract Travel


PROJECT_TERMS: adverse outcome;Animals;Authorization documentation;Characteristics;Chemicals;Contractor;Contracts;Data;Databases;Development;diverse data;Documentation;Economics;Educational workshop;Ensure;Evaluation;flexibility;Guidelines;Hazard Identification;Health;high throughput screening;Human;in silico;In Vitro;in vivo;information gathering;Interagency Coordinating Committee on the Validation of Alternative Methods;interest;Knowledge;Literature;meetings;Methods;Mission;Modeling;National Toxicology Program;novel;Pathway interactions;Peer Review;Performance;pharmacodynamic model;physiologically based pharmacokinetics;Production;Published Comment;Publishing;Quantitative Structure-Activity Relationship;Reporting;Research;research and development;Research Support;Risk Assessment;safety testing;screening;Support Contracts;System;Testing;text searching;Toxicokinetics;Toxicology;Validation;validation studies;Work;Writing

PROJECT_TITLE: NICEATM Support Contract: Optional Level of Effort


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Relevance of the Proposed Work to the VA Patient Care Mission. Noise-induced hearing loss is the most common service-connected condition in Veterans, however noise can also cause damage to the vestibular system resulting in postural instability and compromised balance, leading to increased fall risk. Understanding the mechanism(s) underlying noise-induced vestibular problems will provide the basis for developing treatments to provide functional recovery for Veterans with a history of noise exposure and improve their quality of life. This project will investigate how injury to the inner ear associated with intense noise exposure leads to imbalance and increased fall risk; and will then test a restorative therapy that has shown promise in the auditory system in order to reconnect this compromised system and rehabilitate function.

PI_NAMEs: STEWART, COURTNEY ELAINE (contact)

PROJECT_TERMS: Acceleration;Anatomy;Animal Model;Animals;arm;Auditory;Auditory system;Behavior;behavior measurement;body position;Brain-Derived Neurotrophic Factor;calretinin;Cells;Characteristics;Clinical;clinically relevant;Cochlea;Compensation;Data;Detection;Development;effectiveness evaluation;efficacy testing;equilibration disorder;Equilibrium;Evaluation;Evoked Potentials;Exhibits;experience;Exposure to;fall risk;falls;Fire - disasters;Force of Gravity;Functional disorder;Generations;Goals;Head;Head Movements;Human;improved;Individual;Injury;Labyrinth;Lesion;Link;Literature;macula;Measures;Mediating;Methods;Military Personnel;Mission;Modeling;Motion;Motor;Movement;Mus;Musculoskeletal Equilibrium;nerve supply;Neurons;neurotrophic factor;Neurotrophin 3;Noise;noise exposure;Noise-Induced Hearing Loss;novel;Organ;otoconia;ototoxicity;Pathway interactions;Patient Care;Performance;Peripheral;Persons;Physiological;Physiology;Play;Poloxamers;Positioning Attribute;Posture;posture instability;pressure;Quality of life;Rattus;Reaction;Recording of previous events;Recovery;Recovery of Function;Regenerative capacity;rehabilitation strategy;Rehabilitation therapy;reinnervation;repaired;Reporting;response;Risk;Rodent;Role;Secondary to;Sensory;Services;Severities;sound;Spinal Cord;Synapses;System;Testing;Time;treatment group;Vestibular dysfunction;Vestibular function;Vestibular loss;Vestibular Nerve;vestibular reflex;vestibular system;Vestibule;Veterans;Work

PROJECT_TITLE: Evaluation of noise-induced injury and restorative agents in the vestibular periphery

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Precision Medicine;Prostate Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Urologic Diseases;Women's Health Research

ORG_CITY: Glasgow

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF GLASGOW

ORG_ZIPCODE: G12 8QQ

PI_NAMEs: FROELING, FIEKE  (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Address;Advocate;Africa;African;African ancestry;anti-cancer research;biobank;Biological;black patient;Black race;Blood;Blood specimen;Body Composition;Breast;British;Cancer Biology;cancer health disparity;charity care;Clinical;cloud based;cohort;Collaborations;community engagement;Complex;computer framework;Consent;Data;Data Element;data repository;Databases;design;Development;digital;digital pathology;early onset;Ecosystem;Education;Education and Outreach;Elements;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;Equity;Ethnic Origin;Flow Cytometry;Genetic;genome sequencing;genomic data;Genomics;Geographic Locations;Geography;Germ Lines;health determinants;Health Surveys;Healthcare;Histologic;Immune;Immune response;Immunoassay;Immunofluorescence Immunologic;Immunologic Factors;Immunologics;improved;Incidence;Inequality;Inequity;Informed Consent;Intervention;Joints;Link;Lived experience;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;marginalized population;Mass Spectrum Analysis;Measurement;Measures;member;Methods;Molecular;Natural Selections;Not Hispanic or Latino;novel;Outcome;outcome disparities;outreach;Pancreas;pancreatic cancer patients;Pathogenicity;Pathologist;Pathology;Patient advocacy;Patient Care;Patient Recruitments;Patient Self-Report;patient subsets;Patients;Phenotype;Plasma;Policies;Policy Developments;Population;precision oncology;Predisposition;pressure;Primary Neoplasm;profiles in patients;prospective;Prostate;Race;racism;recruit;Research;Research Personnel;Research Support;Resources;response;Sampling;Science;Scientist;Secure;Shapes;Site;social;social determinants;social factors;social health determinants;social influence;Specimen;structural health determinants;Surveys;sustainability framework;Technology;Tissues;Touch sensation;Training;transcriptomics;Translational Research;treatment and outcome;trial design;tumor;Tumor Tissue;tumor-immune system interactions;Underserved Population;Universities;virtual;Vision;whole genome;Work;X-Ray Computed Tomography

PROJECT_TITLE: SAMBAI: Societal, Ancestry, Molecular and Biological Analyses of Inequalities - University of Glasgow


ADMINISTERING_IC: OD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: EDINBURG

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

ORG_STATE: TX

PHR: The overarching objective of this project is to establish in the US, for the first time, the technologies required to genetically engineer laboratory opossums (which are born at the developmental stage of a 6-week human embryo) for the purpose of answering critical biomedical questions that cannot be answered by research with other laboratory animals. One of the first genetically engineered opossums will be deficient in a gene (Pten) believed, when deficient, to predispose to Autism Spectrum Disorder (ASD). Key outcomes of the project will be to enable establishment of a new animal model for research on ASD, and to make gene editing technology accessible to investigators from other US institutions for novel research with genetically engineered laboratory opossums.

PI_NAMEs: VANDEBERG, JOHN L (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Address;animal breeding;Animal Model;Animals;Area;Auditory;autism spectrum disorder;Behavior;Behavioral;Biomedical Research;Breeding;Characteristics;Collaborations;comparative;Comparative Biology;comparative genomics;Copulation;cost;CRISPR/Cas technology;Development;Developmental Process;Didelphidae;DNA analysis;Ear;Egg Shell;Embryo;Embryology;Experimental Models;experimental study;external ear auricle;Female;Future;gene editing technology;Gene Modified;gene-editing approach;Generations;Genes;Genetic Engineering;Genetically Modified Animals;Genome;Genomic DNA;genomic locus;Genotype;Germ Lines;Grant;Heterozygote;Homozygote;Hour;Human;human disease;Implant;in vivo;Inbred Strain;induced pluripotent stem cell;innovation;Institution;Japanese;Japanese Population;KDM1A gene;Knock-out;knockout gene;Laboratories;Laboratory Animals;Letters;Literature;Mammals;Marsupialia;Medicine;Methods;model of autism spectrum disorder;Modeling;Monodelphis;Monodelphis Domestica;Monophenol Monooxygenase;mosaic;Mus;Natural regeneration;neurodevelopment;Neurodevelopmental Disorder;next generation sequencing;novel;Outcome;Penetration;Preparation;Procedures;Process;programs;Protocols documentation;PTEN gene;reproductive;Research;Research Personnel;Research Project Grants;Resistance;Resources;Rodent;Rodent Model;Role;Science;Siblings;Snake Venoms;success;T-Lymphocyte Subsets;Technology;Time;transmission process;Weaning;Work

PROJECT_TITLE: Creation of Knockout Laboratory Opossums

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LONDON

ORG_NAME: UNIVERSITY COLLEGE LONDON

ORG_ZIPCODE: WC1E 6BT

PI_NAMEs: ANDERSON, JOHN  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Affinity;age group;Antigen Targeting;Antigens;Antineoplastic Agents;Architecture;Binding;Biological Assay;Boston;Brain;CAR T cell therapy;CD276 gene;Cell Physiology;Cells;Cellular immunotherapy;Chemicals;Chemistry;Chemotherapy and/or radiation;Child;Childhood;Childhood Solid Neoplasm;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Clinical;clinical translation;Clinical Trials;clinically relevant;Coculture Techniques;Combination immunotherapy;Complex;Cytostatics;Data;Dependence;design;Development;Diagnosis;Disease;Down-Regulation;Drug Combinations;Drug Controls;drug development;Drug Targeting;early phase clinical trial;engineered T cells;Engineering;Ependymoma;Equilibrium;Evaluation;Ewings sarcoma;exhaustion;FOXO1A gene;Functional disorder;Funding;Gene Expression;Generations;Genes;Glioma;Glues;Heterodimerization;Heterogeneity;high risk;Immune;immune modulating agents;Immunofluorescence Immunologic;Immunology;immunoregulation;improved;in vivo;in vivo Model;Individual;inhibitor;insight;Interphase Cell;Investigation;Kinetics;Legal patent;lenalidomide;Link;Logic;Malignant Childhood Neoplasm;Malignant Neoplasms;Massachusetts;Mediating;Memory;Methods;Modeling;Molecular;mortality;Mutation;neoplastic cell;Neural Cell Adhesion Molecule L1;Neuroblastoma;novel;Nuclear;Oncogenic;Oncoproteins;operation;Patients;Pediatric Neoplasm;Pediatric Oncology;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiologic pulse;pre-clinical;prevent;Printing;progenitor;programs;protein degradation;Protein Inhibition;Proteins;Protocols documentation;Publishing;receptor expression;receptor function;Receptor Signaling;Recovery;recruit;Regulation;Reporting;Research Personnel;Resistance;resistance mechanism;Rest;Risk;Schedule;screening;Signal Transduction;small molecule;Solid;Solid Neoplasm;Specificity;structural biology;success;Survival Rate;synovial sarcoma;synthetic biology;System;T memory cell;T-Cell Receptor Therapy;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Tertiary Protein Structure;Testing;Thalidomide;Therapeutic;tool;tool development;Toxic effect;transcription factor;Transgenes;Transgenic Organisms;translational potential;tumor;Tumor Antigens;Tumor Biology;tumor growth;ubiquitin-protein ligase;Withdrawal;Zinc Fingers

PROJECT_TITLE: PROTECT (Harnessing PROTEin degradation for Advanced Childhood Tumors)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: CHEMISTRY

PHR: Research Strategy: Administrative supplement to purchase ultra-high pressure liquid chromatography coupled high resolution mass spectrometer Parent Grant R01 GM148685 Title for parent grant: Mechanisms of unusual enzymes in the biosynthesis of a copper- containing antibiotic Abstract for parent grant: Enzymes are powerful biocatalysts that may be repurposed for efficient and sustainable synthesis of industrial and pharmaceutical compounds. Identifying novel enzyme-catalyzed reactions and understanding their catalytic mechanisms is essential for expanding the biocatalytic toolbox. We have recently discovered a unique copper-containing antibiotic, fluopsin C, which is produced by Pseudomonas aeruginosa, a leading cause of multidrug-resistant nosocomial infections. By studying how P. aeruginosa makes fluopsin C, we identified an unusual biosynthetic pathway that involves novel enzyme chemistry. For instance, two iron-dependent enzymes of a new heme-oxygenase-like enzyme family catalyze a carbon excision and an oxidative decarboxylation and N-hydroxylation respectively. Two lyases of the adenylosuccinate lyase enzyme family exhibit novel activities of making and breaking carbon-sulfur bonds respectively. The chemistries we identified have expanded the catalytic capabilities of these enzyme families. We hypothesize that the fluopsin C biosynthetic enzymes use novel catalytic mechanisms and can be repurposed or engineered to generate new molecules. To test this hypothesis, we will use a combination of enzyme kinetics, structural biology, spectroscopy, and synthetic chemistry tools, with a focus on three enzymes in fluopsin C biosynthesis. Studies of these distinct enzymes will advance the fundamental understanding of how their respective enzyme family catalyzes diverse chemistry. Defining the mechanisms and substrate scope of the enzymes will allow them to be further explored for biocatalytic use. Scientific justification. The proposed ultra-high pressure liquid chromatography coupled high resolution mass spectrometer (UHPLC-HRMS) will replace a current, but aging equipment of an earlier model in the Li lab that is essential to the success of the NIH-funded project. Our current instrument is an Agilent 6520 Quadruple Time-of-Flight (QToF) coupled with a 1200 series HPLC. We use this instrument extensively for characterization of enzymatic reactions that are described in the parent award. The proposed instrument, 6546 QToF with Jet Stream source coupled with 1290 Infinity II HPLC system, will augment our extant capabilities by improving sensitivity, increasing experiment throughput, and reducing downtime. For instance, the 6546 QToF with Jet Stream source can detect analytes at both low and high concentrations with sub-parts per million mass accuracy and isotope fidelity within 5%. The 1290 Infinity II HPLC system uses a high-speed binary pump with capability of pressure up to 1300 bar and 5 ml/min; the high pressure and flow rate are particularly suitable for separating chiral and polar molecules. Many small- molecule products and intermediates in the enzymatic reactions exhibit minimal ultraviolet-visible (UV-vis) light absorbance, therefore, these compounds cannot be detected via the traditional UV-vis detector. High resolution mass spectrometry detectors are essential for the detection and characterization of these molecules. The requested UHPLC-HRMS will be used for three key aspects of this project: (1) analysis of products of enzymatic assays toward both native and nonnative substrates including isotope-labeled compounds; (2) detection of low-level transient intermediates of enzymatic reactions; 3) metabolomic analysis of bacterial cultures to identify novel natural products. The instrument was not requested in the original grant application because: We did not anticipate the discontinuation of our service contract or availabilities of parts. Our current instrument is 13 years old and was down or under repair for a significant amount of time in the past year (~50 days, approximately 1200 hours or 15% of the year). Last year, we received notice that our instrument can no longer be covered under a service contract due to its age. The manufacturer of the instrument, Agilent Technologies, also stopped making parts for the 6520 model. Also, we did not anticipate the need for ultra-high pressure liquid chromatography for separations of chiral compounds or anticipate the number of metabolomics experiments that we would be performing to identify novel compounds. The requested instrument will replace our existing equipment AND provide new capabilities to advance the goals in the parent award as described below: Aim 1: Mechanism of methine carbon excision by the heme-oxygenase-like enzyme FlcD. The requested UHPLC-HRMS will allow us to characterize the activity of FlcD variants and detect transient intermediates that exist in low quantities in the FlcD reaction. FlcD excises a methine carbon from the oxime of its substrate. To identify essential residues for substrate binding and catalysis, we need UHPLC- HRMS to measure the activities of FlcD variants accurately and quickly. The high-resolution mass spectrometry will also allow us to detect and quantify low-level reaction intermediates amongst high concentrations of substrates and products. Additionally, the instrument with isotope fidelity within 5% is essential for distinguishing the products with mass differences less than 1 Da from isotope labeling experiments. Aim 2: Mechanism of oxidative decarboxylation and N-hydroxylation by the heme-oxygenase-like enzyme FlcE. The requested UHPLC-HRMS will allow us to characterize the activity of FlcE variants and detect transient intermediates that exist in low quantities in the FlcE reaction. FlcE catalyzes sequential decarboxylation and N-hydroxylation. Similar UHPLC-HRMS analysis as described in Aim 1 is essential for high-throughput characterization of FlcE variants to identify essential catalytic residues and low-level reaction intermediates. In addition, we are expanding our study to include homologs of FlcD and FlcE that we have identified in uncharacterized biosynthetic gene clusters. Metabolomic capabilities of the UHPLC-HRMS will enable us to identify new natural products and novel functions of heme oxygenase-like enzymes. Aim 3: Substrate scope analysis and bioengineering of the adenylosuccinate lyase FlcB. The requested UHPLC will allow us to characterize the activity and enantioselectivity of FlcB and variants in a high-throughput format. We found that the adenylosuccinate lyase FlcB exhibits a broad substrate scope toward thiol and amine nucleophiles that is different from its native substrate cysteine. We are characterizing the regio- and stereo-selective formation of both C-S and C-N bonds by measuring the enantio excess and turnover number of each reaction in triplicates. The proposed instrument will allow us to analyze >100 samples a day while providing high resolution to separate the enantiomers. This capability will enable us to examine the activity our engineered variants of FlcB much more quickly and accelerate the identification of useful variants as biocatalysts. Routine training and maintenance: Every personnel on the project will participate in the initial on-site training by the manufacturer (Agilent). One person in the group will be designated the person-in-charge on the instrument, and this person will train other new users in the group. Maintenance on the LC will be covered by a service contract, which includes preventative maintenance visits once a year and unlimited on-site repairs. Timeline for installation: The instrument will be delivered and installed on average 7 weeks after the order is placed. We expect the instrument to be fully functional by that time.

PI_NAMEs: LI, BO  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: 13 year old;Acceleration;adenylosuccinate lyase;Administrative Supplement;Age;Aging;Amines;Anabolism;Antibiotics;Applications Grants;Binding;Biochemical Reaction;Biological Assay;Biomedical Engineering;Carbon;Catalysis;Charge;Chemistry;Contract Services;Copper;Coupled;Cysteine;Decarboxylation;Detection;detector;enantiomer;Engineering;Enzyme Kinetics;Enzymes;Equipment;Excision;Exhibits;experimental study;Family;fluopsin;Funding;Gene Cluster;Goals;Heme;High Pressure Liquid Chromatography;Homologous Gene;Hour;Human Resources;improved;Industrialization;instrument;Iron;Isotope Labeling;Isotopes;Lyase;Maintenance;Manufacturer;mass spectrometer;Mass Spectrum Analysis;Measures;metabolomics;Modeling;Multi-Drug Resistance;N hydroxylation;Natural Products;non-Native;Nosocomial Infections;novel;Oximes;Oxygenases;parent grant;parent project;Pathway interactions;Persons;Pharmacologic Substance;pressure;Pseudomonas aeruginosa;Pump;Reaction;repaired;Research;Resolution;Sampling;Series;Site;small molecule;Source;Spectrum Analysis;Speed;Stream;structural biology;success;Sulfhydryl Compounds;Sulfur;Synthesis Chemistry;System;Technology;Testing;Time;timeline;tool;Training;ultra high pressure;ultraviolet;United States National Institutes of Health;Variant;Visible Radiation;Visit

PROJECT_TITLE: Ultra-high pressure liquid chromatography coupled high resolution mass spectrometer


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Pericytes are a key cell type in the capillary wall, and their deficiency during Alzheimer’s disease leads to impairment of important vascular functions, such as blood-brain barrier integrity and regulation of blood flow. This project uses cutting-edge live imaging to study the dynamics of brain pericytes in live mice, with the goal of revealing how the brain responds and adapts to pericyte loss. It will also test whether augmentation of pericyte-endothelial coverage can improve capillary health and function in adult and aged brains.

PI_NAMEs: SHIH, ANDY Y (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Ablation;Acceleration;Address;Adult;Affect;Age;age-related disease;aged;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Autopsy;Basement membrane;Biology;Blood - brain barrier anatomy;Blood capillaries;Blood flow;Blood Vessels;Brain;brain dysfunction;brain pericytes;capillary bed;cell type;Cells;cerebral capillary;Cerebral cortex;cerebrovascular;Cerebrovascular Disorders;cerebrovascular health;Communication;Compensation;Data;Development;Endothelium;Event;Gene Expression;Genetic;genetic manipulation;Goals;Health;hemodynamics;Histologic;Hypoxia;Image;imaging probe;Impairment;improved;in vivo;in vivo calcium imaging;in vivo imaging;in vivo two-photon imaging;innovation;insight;Invaded;Investigation;knock-down;Knowledge;Life;Maintenance;Measures;Methods;middle age;Modeling;multidisciplinary;Mus;Mutant Strains Mice;neural;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;neurovascular;novel;old mice;Optics;Oxygen;PDGF inhibition;PDGFRB gene;Peptides;Pericytes;pharmacologic;Physiological;Platelet-Derived Growth Factor;platelet-derived growth factor BB;Platelet-Derived Growth Factor beta Receptor;preservation;Process;recruit;Regulation;repair strategy;repaired;reparative process;Reporting;Resolution;response;Role;Severities;Signal Pathway;Signal Transduction;Stretching;Structure;Synapses;synaptic function;Testing;Theft;tissue oxygenation;Tissues;two photon microscopy;two-photon;Work

PROJECT_TITLE: Pericyte structural plasticity and cerebrovascular health


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Eating Disorders;Mental Health;Mental Illness;Pediatric

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE Among adolescents, research consistently links greater time spent on social media (SM) with depressive symptoms and body dissatisfaction, which are prevalent mental health symptoms that cause significant distress even at subclinical levels and can develop into more severe psychopathology such as major depressive disorder and eating disorders. Social comparison may be one central mechanism explaining associations of SM use with depressive symptoms and body dissatisfaction; however, studies examining social comparison as a mechanism have primarily been limited to cross-sectional assessments and have not sufficiently measured the degree of sequencing and timing needed to address context-dependent fluctuations in behavior and symptoms, nor how specific SM activities (e.g., passive versus active use) relate to mental health. This proposal will examine bidirectional influences of adolescents’ SM activity on depressive symptoms and body dissatisfaction through the lens of social comparison theory, and will identify modifiable intervention targets to reduce harmful SM use and mental health symptoms.

PI_NAMEs: COHN, AMY M;VOGEL, ERIN ALYSSA (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Acquaintances;Address;Adolescent;adolescent mental health;Affect;age group;aged;Attitude;Behavior;Behavior assessment;Behavioral;body dissatisfaction;Characteristics;Code;depressive symptoms;Distant;Distress;Eating Disorders;Ecological momentary assessment;Environment;experience;Exposure to;Feedback;fitness;Friends;Future;Gender;Individual;Instagram;Intervention;Investigation;lens;Link;Literature;Longitudinal, observational study;Major Depressive Disorder;Measures;media use;Mental Health;Modeling;Modernization;Monitor;multilevel analysis;novel;Participant;Personal Satisfaction;Personality Traits;Play;Population;Prevalence;Prevention;protective factors;Psychopathology;Published Comment;Publishing;recruit;Reporting;Research;Risk;Risk Factors;Role;rumination;satisfaction;Schedule;single episode major depressive disorder;smartphone application;social;social influence;social media;Social Reinforcement;Socialization;sociodemographics;Surveys;Symptoms;Terminology;Testing;theories;therapy development;Thinking;Time;trait;trend;Youth

PROJECT_TITLE: Social Comparison on Social Media, Depressive Symptoms, and Body Dissatisfaction among Adolescents

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (05)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Neurosciences;Pain Research

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE The overall goal of the proposed University of Michigan (UM) HEAL National K12 Clinical Pain Career Development Program (UM-HCPDP) is to develop a national training program for early career clinician- scientists so as to grow the next generation of clinical pain research scholars. This national K12 program develops guidelines for career development and mentoring in clinical pain research, and coordinates training for scholars across institutions and mentorship teams, and with the Coordinating Center for National Pain Scientists Program (CCNPS). The UM-HCPDP seeks to train clinician-scientists with a deep understanding of pain mechanisms, non-opioid treatment options, scientific methodological rigor, leadership, patient-centric perspectives, and compassion for those who are suffering.

PI_NAMEs: CLAUW, DANIEL J;HARTE, STEVEN EDWARD;WILLIAMS, DAVID A (contact)

PROGRAM_OFFICER_NAME: SYPEK, ELIZABETH IRENE

PROJECT_TERMS: Advisory Committees;Anesthesiology;career;career development;chronic pain;clinical pain;Compassion;Data Science;Development;Education;Eligibility Determination;Epidemiology;Ethics;experience;Faculty;Fatigue;Fellowship;Goals;Guidelines;Helping to End Addiction Long-term;Home;improved;Institution;International;Leadership;Mediation;Mentored Clinical Scientist Development Program;Mentors;Methodology;Methods;Michigan;multidisciplinary;next generation;non-opioid analgesic;Occupations;Pain;Pain Research;Patients;Persons;Positioning Attribute;post-doctoral training;Professional Organizations;Program Development;programs;Research;Research Methodology;Research Personnel;Residencies;Scientist;skills;Time;Training;Training Programs;Universities

PROJECT_TITLE: University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP)


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: Project Narrative One of the most significant barriers to health-related research involving small molecules is the rapid assembly of therapeutic agents. This proposal seeks to develop new methods to synthesize complex frameworks using easily accessible precursors with high efficiency.

PI_NAMEs: ROVIS, TOMISLAV  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Alkenes;Alkylation;Amides;Amines;aryl halide;Automobile Driving;Carboxylic Acids;Catalysis;catalyst;Chemistry;chlorination;Cobalt;Complex;Copper;Coupling;dehydrogenation;design;Distal;Drug Design;drug discovery;efficacious treatment;FDA approved;functional group;Funding;Goals;Health;human disease;Hydrogen Bonding;Imines;interest;Metals;Methods;Nickel;Nitrogen;Oxidation-Reduction;Pharmaceutical Preparations;Pharmacologic Substance;Planet Earth;Positioning Attribute;Principal Investigator;programs;Protocols documentation;Reaction;Research;Salts;scaffold;Site;small molecule;Sodium Chloride;success;Sulfhydryl Compounds;System;tertiary amine;Therapeutic Agents;Uncertainty;Work

PROJECT_TITLE: Selective Functionalization of Aliphatic Amines

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Development of Hybrid Operations to Promote Equity (HOPE) will address clinical trial disparities in North Carolina’s diverse patient population by creating an infrastructure for hybrid decentralized trials (DCTs) and building a network of engaged physicians to refer patients to such opportunities. These efforts are focused on increasing clinical trial access to underserved communities by reducing geographic enrollment barriers and using culturally competent local health care providers. The aims of this proposal will promote equity in clinical trials and improve outcomes for all patients, regardless of their age, race, ethnicity, gender, background, or geographic location.

PI_NAMEs: LEE, CARRIE B;MORRISON, JULIA KAITLIN (contact)

PROGRAM_OFFICER_NAME: HSIEH, JULIE

PROJECT_TITLE: Building Hybrid Operations to Promote Equity (HOPE) and improve clinical trial access across North Carolina

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 OC-T (03)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Neurosciences;Pediatric

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE This project will result in a realistic, developmentally-salient, and ecologically-valid fMRI/eye-tracking task that simulates modern SM use which will be disseminated for use in future studies that will advance understanding of the role of neural sensitivity to social evaluation in mediating or moderating the bidirectional links between SM use and emotional health in teens. This will facilitate prevention and intervention efforts by helping to identify (1) neural characteristics of youth at highest risk for emotional health problems related to SM use, (2) how SM use affects and is affected by the brain, and (3) related neural and attentional targets for intervention, using strategies such as transcranial magnetic stimulation or attention bias modification in the context of SM. Findings on which aspects of SM use are most strongly linked to brain functioning and emotional health may also inform SM practice recommendations for vulnerable youth and related policy.

PI_NAMEs: KARIM, HELMET TALIB;SILK, JENNIFER S (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Address;Adolescent;Affect;Affective;Age;Amygdaloid structure;Anterior;Attention;attentional bias;Automobile Driving;boys;Brain;Brain region;Characteristics;cingulate cortex;Consensus;Cues;depressive symptoms;design;Development;digital;Dorsal;Ecological momentary assessment;Emotional;Epidemic;ethnic diversity;Ethnic Origin;Evaluation;Exhibits;experience;Face;Feedback;Fright;Functional Magnetic Resonance Imaging;Funding;Future;gender diverse;gender diversity;girls;Goals;Health;high risk;improved;indexing;Insula of Reil;interest;Intervention;Link;Measures;media use;Mediating;Mental Depression;Mental Health;Modernization;Modification;neural;neural circuit;neural correlate;Neurophysiology - biologic function;Occupations;Patient Self-Report;peer;Phase;pilot test;Policies;Predisposition;Prevention;Process;programs;Published Comment;Questionnaires;Race;racial diversity;Recommendation;Research;Research Personnel;response;Rewards;Role;Sampling;Scanning;Severities;social;Social Interaction;social media;Stimulus;success;Suggestion;teen driving;Teenagers;Testing;Transcranial magnetic stimulation;Ventral Striatum;Visual attention;visual tracking;Youth

PROJECT_TITLE: Development of a new social media fMRI task to better investigate bidirectional links between social media use and emotional health in youth.


ADMINISTERING_IC: DP

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Rates of absenteeism and hospitalizations due to influenza remain high, as do HPV-related cancers, despite effective vaccinations being available. We will test the effect of training school nurses and teachers as well as messages to parents from school with a goal of reducing vaccine hesitancy and increasing influenza and HPV vaccination rates for children and adolescents, to ultimately reduce influenza and HPV-related morbidity and mortality.

PI_NAMEs: BARNETT, STEVEN L;RAND, CYNTHIA M (contact)

PROGRAM_OFFICER_NAME: DARLING, NATALIE

PROJECT_TITLE: Trusted School Messengers Promoting Non-Mandated Vaccination

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (06)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Neurodegenerative;Neurosciences;Organ Transplantation;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Of the 170,000 older (≥50) kidney transplant (KT) recipients in the US, we have estimated that 19% experience post-KT cognitive decline, and up to 17% are diagnosed with dementia and Alzheimer’s Disease (AD). Air pollution is likely an important modifiable risk factor for post-KT cognitive aging. We seek to estimate the impact of air pollution on incident dementia/AD; these aims are supported by a comprehensive training program includes courses and mentorship on health equity, epidemiology, and gerontology and is designed to support the candidate as she becomes a clinician scientist.

PI_NAMEs: MCADAMS DEMARCO, MARA A. (contact)

PROGRAM_OFFICER_NAME: EL KASSAR, NAHED

PROJECT_TERMS: Acceleration;Accounting;Address;Adult;Affect;Age;age related;aged;Aging;Air;Air Pollution;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Behavior;Biological;black patient;Black race;built environment;Cardiovascular Diseases;Career Choice;Chronic Disease;Classification;Climate;climate change;climate-related health;Clinical;Clinical Research;clinical training;Cognition;Cognitive;Cognitive aging;cognitive function;cohort;Cohort Studies;Communities;community advisory board;community engagement;community-level factor;Complement;Complex;Consensus;Data;Databases;Dedications;Delirium;Dementia;dementia risk;design;Development;Diagnosis;diagnostic criteria;Dialysis procedure;Dimensions;Disparity;End stage renal failure;Enrollment;Environmental Exposure;Environmental Impact;Epidemiology;epidemiology study;Event;experience;Exposure to;extreme heat;extreme weather;Family;fine particles;Foundations;Functional dependence;Funding;Future;Gerontology;Glean;Goals;graft function;Grant;Health;health care availability;health disparity;health equity;Health equity research;Heat Waves;Hemodialysis;Hurricane;Immunosuppression;Impaired cognition;indexing;Individual;Inflammation;Inflammatory;Institution;Institutional Racism;Intervention;Kidney;Kidney Transplantation;Life Cycle Stages;life span;lifetime risk;Link;Measurement;Measures;Mediating;Mediation;Medical;Medical Residency;medical schools;Medicare;Mentorship;Mission;Modeling;modifiable risk;mortality;mortality risk;multiple chronic conditions;National Institute on Aging;National Oceanic and Atmospheric Administration;Natural Disasters;Nerve Degeneration;neuropathology;neurotoxic;Odds Ratio;older adult;older patient;Operative Surgical Procedures;Outcome;Patients;Phase;Policies;Population;Postoperative Period;premature;prevent;Process;promote resilience;Prospective, cohort study;racism;Registries;Research;Research Methodology;Research Personnel;Residencies;resilience;resilience biomarker;Risk;Risk Factors;Scientist;skills;social;Social Environment;social vulnerability;socioeconomics;Structural Racism;Testing;Time;Training;Training Programs;Transplant Recipients;United States National Aeronautics and Space Administration;United States National Institutes of Health;Vulnerable Populations;Writing

PROJECT_TITLE: Structural Racism, Resilience, and Premature Cognitive Aging in End-Stage Renal Disease  - Revision - 5


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Precision Medicine;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Urologic Diseases;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PI_NAMEs: YATES, CLAYTON  (contact)

PROJECT_TERMS: Adverse effects;Affect;Africa;African;African American population;African ancestry;anti-cancer research;Area;B-Lymphocytes;biobank;Biological;Biological Tumor Markers;Biology;black patient;Blood specimen;cancer health disparity;Cancer Patient;cancer risk;Cell Cycle;cell type;Cells;circulating biomarkers;Clinical;cloud based;cohort;Collaborations;computer framework;Data;Data Element;data repository;Databases;design;Development;digital pathology;Discrimination;early onset;Elements;Environment;Environmental Exposure;Epigenetic Process;Equity;exhaustion;experience;flexibility;Flow Cytometry;Gene Expression;Genetic;genome sequencing;Genomics;Geography;Germ Lines;Goals;Histologic;Image;Immune;Immune response;Immunoassay;Immunofluorescence Immunologic;Immunologic Factors;Immunologic Surveillance;Immunologics;improved;Incidence;Inequity;Inflammation;Infrastructure;Institutional Racism;Intervention;Joints;Link;Lived experience;Lymphocyte;Lymphocyte Activation;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;marginalization;marginalized population;Mass Spectrum Analysis;Measurement;Measures;member;Methods;molecular dynamics;Neighborhoods;novel;Outcome;outcome disparities;pancreatic cancer patients;Pathologist;Patient advocacy;Patient Selection;Patient Self-Report;Patients;Phenotype;Physiology;Plasma;Platinum;Population;Population Heterogeneity;precision oncology;Predisposition;Primary Neoplasm;Process;profiles in patients;Proteins;Protocols documentation;Publishing;Quality of life;racism;Refractory;Research;Research Personnel;Resources;response;Science;Scientist;Serum;Site;social;social determinants;social factors;social health determinants;Social stratification;spatial relationship;Specimen;structural determinants;Structural Racism;Surveys;sustainability framework;System;systemic inflammatory response;Systemic Therapy;T memory cell;T-Lymphocyte;Technology;Testing;Tissue Microarray;transcriptomics;treatment and outcome;treatment response;trial design;tumor;Tumor Biology;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;Underserved Population;virtual;White Blood Cell Count procedure;whole genome;Work

PROJECT_TITLE: Understand the mechanisms through which genetics, biology, and social determinants affect cancer risk and outcomes in diverse populations, to motivate interventions to reduce cancer inequities


ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Decades of research have demonstrated that the immune system can eradicate cancer cells but only if immune evasion mechanisms, such as immune checkpoint proteins, can be overcome. Multiple new immunotherapeutic approaches have recently been developed that can induce durable remissions in patients with advanced cancers – unfortunately, the majority of patients still succumb to their cancers. The goal of this COBRE application is to establish a new Center for Cancer Immunology and Immunotherapy that will focus on understanding immune escape mechanisms, developing new approaches to activate/reinvigorate anticancer immunity, training promising young cancer immunologists and improving the research infrastructure of the University of Louisville.

PI_NAMEs: CHESNEY, JASON A.;YAN, JUN  (contact)

PROJECT_TERMS: Address;Adoptive Cell Transfers;Advanced Malignant Neoplasm;Aftercare;Animal Model;anti-cancer;anti-CTLA4;anti-PD-1;Award;B-Lymphocytes;Basic Science;Binding;Bioinformatics;Biological;Biological Markers;Biological Models;Biopsy;Blood;cancer cell;Cancer Center;cancer immunotherapy;Cancer Patient;cancer therapy;Cells;Cellular Assay;Centers of Research Excellence;Clinic;Clinical;Clinical Data;Clinical Research;Clinical Trials;Collaborations;Complex;Cytometry;Data;Data Analyses;data analysis pipeline;data integration;Data Science;Data Set;design;Development;Disease remission;efficacy testing;Faculty;Foundations;Funding;Future;Genetic;genomic data;Genomics;Goals;Health;High-dimensional Modeling;human model;Image;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immune system;Immunogenetics;Immunogenomics;Immunohistochemistry;Immunologic Factors;Immunologics;Immunologist;Immunotherapeutic agent;Immunotherapy;immunotherapy clinical trials;improved;Individual;Infiltration;Infrastructure;Infusion procedures;innovation;Interdisciplinary Study;Interleukin-15;Knowledge;Link;lymphocyte product;machine learning model;machine learning prediction;Malignant Neoplasms;medical schools;Melanoma;Melanoma patient;Membrane;Mentors;Methodology;Methods;Mission;Modeling;Motivation;multidimensional data;multidisciplinary;multiple omics;Myeloid Cells;Nature;neoantigens;next generation;novel;novel strategies;novel therapeutics;Outcome;outcome prediction;Parents;Participant;Patient Care;Patient Participation;Patient-Focused Outcomes;Patients;Peripheral;Phase;Phase I/II Clinical Trial;Population;predict clinical outcome;Prediction of Response to Therapy;Predictive Factor;profiles in patients;programs;Proteins;receptor;Refractory;Research;Research Infrastructure;Research Personnel;Research Project Summaries;Resistance;Resolution;Resources;response;Science;single-cell RNA sequencing;skills;specific biomarkers;Stress;success;Survival Rate;T-Cell Receptor;T-Lymphocyte;Targeted Research;Testing;Therapeutic;therapy outcome;therapy resistant;Time;Tissues;tool;Training;transcriptome;transcriptomics;Translational Research;Treatment Efficacy;Treatment outcome;treatment response;treatment strategy;tumor;Tumor Expansion;Tumor Immunity;tumor immunology;tumor progression;Tumor Tissue;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Center for Cancer Immunology and Immunotherapy (CCII).


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Prostate Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Urologic Diseases

ORG_CITY: NOTTINGHAM

ORG_NAME: UNIVERSITY OF NOTTINGHAM

ORG_ZIPCODE: NG7 2RD

PI_NAMEs: MONGAN, NIGEL  (contact)

PROJECT_TERMS: Address;Advocate;Africa;African;African ancestry;anti-cancer research;Antibodies;biobank;Biological;Biological Tumor Markers;black patient;Black race;Blood;Blood specimen;Breast;British;Cancer Biology;cancer health disparity;Cell Communication;Cells;charity care;Clinical;cloud based;cohort;Collaborations;Communities;community engagement;Complex;computer framework;Consent;Data;Data Element;data repository;Databases;design;Development;digital;digital pathology;DNA;early onset;Ecosystem;Education;Education and Outreach;Environment;Environmental Exposure;Epigenetic Process;Equity;Flow Cytometry;Gene Expression;Genetic;genome sequencing;genomic data;Genomics;Geographic Locations;Geography;Germ Lines;health determinants;Health Surveys;Healthcare;Histologic;Immune;Immune response;Immunoassay;Immunologic Factors;Immunologics;Immunophenotyping;improved;Incidence;Inequality;Inequity;Informed Consent;insight;Intervention;Joints;Link;Lived experience;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;marginalized population;Mass Spectrum Analysis;Measurement;Measures;member;Methods;Molecular;Natural Selections;Non-Malignant;Not Hispanic or Latino;novel;outcome disparities;outreach;Pancreas;pancreatic cancer patients;Pathogenicity;Pathologic;Pathologist;Patient advocacy;Patient Care;Patient Self-Report;Patients;Plasma;Policies;Policy Developments;Population;precision oncology;Predisposition;pressure;Primary Neoplasm;profiles in patients;Prostate;Race;racism;recruit;Refractory;Research;Research Personnel;Research Support;Resources;response;Sampling;Science;Scientist;Secure;Shapes;Site;social;social determinants;social factors;social health determinants;social influence;Specimen;Standardization;structural determinants;structural health determinants;Surveys;sustainability framework;Technology;Tissue Microarray;Tissues;tool;Touch sensation;transcriptomics;Translational Research;treatment and outcome;trial design;Trust;tumor;Tumor Biology;Tumor Tissue;Underserved Population;Universities;virtual;Vision;whole genome;Work

PROJECT_TITLE: Societal, Ancestry, Molecular and Biological Analyses of Inequalities: SAMBAI


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Despite an increased healthcare system investment in primary care screenings to identify the psychosocial needs of caregivers and children (e.g., exposure to violence, racism, and insecure housing), these efforts don’t always result in family-centered service referrals and follow-up to ensure all needs are getting met (i.e., families able to access services such as housing and behavioral health support). Our preliminary data identified key strengths and weaknesses within families’ journeys through psychosocial screenings, service referral, and linkage processes in primary care – which we term “service pathways”. In this R01 study, after optimizing service pathways (Aim 1), we will conduct a cluster-randomized trial to test the impact of CARELOOP on effectiveness (Aim 2) and implementation outcomes (Aim 3).

PI_NAMEs: JOLLES, MONICA PEREZ (contact)

PROGRAM_OFFICER_NAME: SAGATOV, ROBYN

PROJECT_TITLE: Using process mapping to optimize the integration of child psychosocial screenings in primary care, promote whole-person care, and increase family linkages to behavioral and safety net services

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative The proposed study is designed to support efforts to promote the participation of diverse populations in clinical trials with a specific focus on linguistic inclusion. Specifically, we will examine Spanish-speaking individuals’ perspectives, preferences, and unmet needs when considering joining clinical trials. The data will inform innovative educational and communication strategies for investigators as well as ongoing BU CTSI institutional change efforts designed to advance linguistic inclusion.

PI_NAMEs: ALVAREZ-HERNANDEZ, LUIS R.;SPRAGUE MARTINEZ, LINDA SUSAN (contact)

PROJECT_TITLE: Advancing Health Equity Through Linguistic Inclusion in Clinical Trials

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 OC-T (02)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The Paramyxoviridae family includes several pathogenic viruses that pose major threats to human health, including human parainfluenza virus 3 (HPIV3) which causes illness or death in millions of infants and young children, and the lethal Nipah (NiV) and Hendra (HeV) viruses that pose a risk of global emergence. We propose to apply the results of our fundamental research to advance a potent new antiviral strategy that is based on the use of fusion-inhibitory peptides to block viral entry.

PI_NAMEs: MOSCONA, ANNE  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Accidents;acute toxicity;African Green Monkey;Amino Acids;Animal Model;Animals;Anti-viral Agents;anti-viral efficacy;Anti-viral resistance;Antibodies;appendage;base;Binding Proteins;Biodistribution;Biological Assay;Brain;Bronchiolitis;Cell membrane;Cells;Cessation of life;Child;Childhood;Chimeric Proteins;Clinical;combat;Complex;conformational conversion;Cotton Rats;Croup;design;Drug Kinetics;efficacy evaluation;efficacy study;Ensure;env Gene Products;Evolution;experimental study;Family;Finding by Cause;fundamental research;Glycoproteins;Goals;Half-Life;Health;Hemagglutinin;Hendra;Hendra Virus;Henipavirus;Human;human disease;immunogenicity;improved;In Vitro;in vivo;Infant;Infection;Inhalation;Inhalation Drug Administration;inhibitor;innovation;Interruption;Lead;lead candidate;Lipids;Lung;Mediating;Membrane;Membrane Fusion;Mesocricetus auratus;Methods;Modeling;Modification;Molecular;Molecular Conformation;Mutation;Neuraminidase;Nipah Virus;Nose;novel;Organoids;Para-Influenza Virus Type 3;parainfluenza virus;Paramyxovirus;passive immunoprophylaxis;pathogenic virus;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pneumonia;Positioning Attribute;Preparation;prevent;Property;prophylactic;protein aminoacid sequence;Proteins;prototype;receptor binding;Receptor-Interacting Protein;Resistance;Resistance development;resistance mechanism;respiratory virus;Risk;Rodent;Self Administration;Series;Site;Structure;Structure of parenchyma of lung;System;Therapeutic;Tissue Model;Tissues;transmission process;vaccine access;Validation;Vertebral column;Viral;viral entry inhibitor;Viral Physiology;viral resistance;Virus

PROJECT_TITLE: Broad spectrum inhibitors of paramyxovirus envelope proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(82)]


ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative: This project will systematically identify substrates and functions of calcineurin, which regulates many processes in humans by mediating Ca2+-dependent changes in protein phosphorylation. Misregulation of calcineurin underlies immune disorders, diabetes, cancer, heart disease and epilepsy. This research studies calcineurin function at a biochemical and structural level and will provide new insights into its actions in healthy and diseased cells, thus uncovering new therapeutic approaches to control its activities selectively.

PI_NAMEs: CYERT, MARTHA S. (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: adaptive immune response;Address;Affinity;Bar Codes;Biochemical;Biotin;C-terminal;Calcineurin;Calcineurin inhibitor;calcineurin phosphatase;Calmodulin;Cardiovascular system;Cell Physiology;Cells;Centrosome;Coupled;Cyclosporine;Diabetes Mellitus;Disease;Enzymes;Epilepsy;Eukaryota;Explosion;FK506;Future;Heart Diseases;Human;Hypertension;Immune system;Immune System Diseases;Immunosuppressive Agents;in silico;in vivo;insight;Knowledge;Label;Ligase;Location;Malignant Neoplasms;Maps;Mediating;Membrane;Methods;Microspheres;Nervous System;new technology;novel strategies;novel therapeutic intervention;nuclear factors of activated T-cells;Nuclear Pore Complex;palmitoylation;Peptides;Pharmaceutical Preparations;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Process;protein aminoacid sequence;Protein Dephosphorylation;Protein Isoforms;Protein Kinase;Protein phosphatase;Proteins;ratiometric;Regulation;Research;research study;Role;Saccharomyces cerevisiae;Seizures;sensor;Signal Pathway;Signal Transduction;Tissues;transcription factor;Work

PROJECT_TITLE: Systematic elucidation of calcineurin phosphatase signaling in humans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: BOWLING GREEN

ORG_NAME: WESTERN KENTUCKY UNIVERSITY

PHR: Adolescents with persistent suicidal thoughts are at greater risk for future suicide attempts. Students identifying as gender and sexual minorities (SGM) are at even greater risk for suicide. Identifying factors that relate to diminishing suicide ideation will aid in the development of prevention and early intervention programs for SGM youth.

PI_NAMEs: BRAUSCH, AMY MARIE (contact)

PROJECT_TERMS: Adolescent;Age;Analysis of Variance;behavior measurement;career;Cause of Death;cisgender;Clinical Psychology;Cognitive;contextual factors;Development;Disease remission;Doctor of Philosophy;Early Intervention;eleventh grade;Feeling hopeless;Feeling suicidal;follow up assessment;Food;Future;gender minority status;gender minority youth;Goals;health care availability;Heterosexuals;High School Student;Home;Housing;ideation;intervention program;Knowledge;Longitudinal Studies;low socioeconomic status;Mental Depression;Mentors;parent grant;Patient Self-Report;preventive intervention;programs;Protocols documentation;Psychiatric Diagnosis;Public Health;Recording of previous events;recruit;Remittance;Reporting;Research;Resources;Risk;Risk Factors;Rural;Sampling;Schools;Security;Self Efficacy;Sexual and Gender Minorities;sexual minority youth;Social support;Socioeconomic Status;Students;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide rate;teacher;Testing;Youth

PROJECT_TITLE: Cognitive and Contextual Factors in Suicide Ideation Persistence in Adolescents


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: OVERALL: PROJECT NARRATIVE The mission of the Southern California Environmental Health Sciences Center is to develop the scientific knowledge base, investigator teams, and community engagement that leads to reduced burden of disease and disability from environmental impacts on major health outcomes, especially among vulnerable populations.

PI_NAMEs: MCCONNELL, ROB S (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Academic support;Address;Air;Air Pollution;Area;base;Biological;Biological Process;Biometry;burden of illness;California;career;career development;Clinical;Collaborations;Communication;Communities;community engagement;Community Health;community involvement;community organizations;community partners;Complex;consumer product;Core Facility;critical developmental period;Data Science;Development;disability;Disease;Disparity population;Droughts;Early Diagnosis;Educational workshop;Elements;Environment;environmental change;Environmental Exposure;Environmental Hazards;Environmental Health;environmental health disparity;Environmental Impact;experience;Food;Fostering;Future;General Population;Goals;Government Officials;Growth;Health;health literacy;Health protection;health science research;Health Sciences;heat island;human disease;improved;innovation;Integration Host Factors;Integrative Medicine;Interdisciplinary Study;International;Intervention;knowledge base;learning community;Life Cycle Stages;Malignant Neoplasms;Mediating;Metabolic;Methods;Mission;Modeling;Molecular;multidisciplinary;National Institute of Environmental Health Sciences;Neurologic;next generation;novel;Obesity;Outcome;Outcomes Research;Pathway interactions;Pilot Projects;Policies;Policy Maker;Population;Positioning Attribute;Predisposition;Professional Organizations;programs;Public Health;recruit;Research;Research Methodology;Research Peer Review;Research Personnel;Research Project Grants;Resources;response;Science;Scientist;Series;social;social disparities;Soil;Strategic Planning;Structure;success;symposium;Translating;Translational Research;trend;Urbanization;Vulnerable Populations;Water;Wildfire;working group

PROJECT_TITLE: Environmental Exposures, Host Factors and Human Disease

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P0)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Physical Activity;Prevention;Rehabilitation

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE  Using a neuroscientific approach grounded in the pathophysiology of Alzheimer's disease, the proposed study will cross disciplines of neuroscience, health, and technology to investigate the effects of a targeted, simultaneous physical and cognitive activity intervention on brain health and cognition in individuals with early mild cognitive impairment. Results from this study will provide new evidence for a combined intervention to enhance cognition and brain health in older adults at risk for Alzheimer's disease.

PI_NAMEs: PA, JUDY  (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: 3-Dimensional;active control;Adult;Affect;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Animals;arm;Behavior;Behavior Therapy;Birth;blood-based biomarker;Brain;brain health;Brain imaging;brain magnetic resonance imaging;Brain-Derived Neurotrophic Factor;cardiovascular fitness;cell motility;Cell Survival;Cells;cerebral atrophy;Clinical Trials;Cognition;Cognitive;cognitive control;cognitive training;comparison control;Control Groups;Coupled;Data;Dementia;Discipline;Disease;educational atmosphere;effective therapy;Environment;executive function;Exercise;exercise intensity;exercise intervention;Exposure to;Functional disorder;Goals;Health;Heart Rate;Hippocampus;Image;Impaired cognition;improved;Individual;Insulin-Like Growth Factor I;interest;Intervention;Intervention Trial;Learning;lifestyle intervention;Literature;Long-Term Potentiation;Maintenance;Measurement;Measures;Memory;Methodology;mild cognitive impairment;moderate-to-vigorous physical activity;neurogenesis;Neurosciences;novel;older adult;Outcome;Participant;Peripheral;Persons;pharmacologic;Phase;Phase II Clinical Trials;Physical activity;physical conditioning;Populations at Risk;Positioning Attribute;Positron-Emission Tomography;post intervention;Prefrontal Cortex;prevent;programs;Publishing;Randomized;recruit;Safety;Series;sobriety;spatial memory;Stimulus;Structure;Supervision;Technology;Testing;Time;Training;Training Programs;treatment effect;Vascular Endothelial Growth Factors;vigorous intensity;virtual environment;virtual reality;virtual reality environment;virtual reality intervention;VO2max;way finding;Work;β-amyloid burden

PROJECT_TITLE: Targeted Physical and Cognitive Activity in a VR Environment in Older Adults at Risk for Alzheimer's Disease


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Patient Safety;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: PROJECT NARRATIVE This study seeks to provide large-scale, foundational evidence that high-intensity rehabilitation is effective and can be systematically implemented to improve functional outcomes for patients admitted to skilled nursing facilities following hospitalization. Additionally, this study will generate a descriptive overview of factors that predict implementation success while informing effective implementation strategies for future skilled nursing facilities innovation. Overall, this study is a critical step in advancing clinical practice to establish high-intensity rehabilitation as an effective standard of care in skilled nursing facilities to shift current treatment away from low-intensity, conservative interventions.

PI_NAMEs: STEVENS-LAPSLEY, JENNIFER E. (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Activities of Daily Living;Acute;acute care;Address;Admission activity;Adopted;Adoption;Adult;Adverse event;appropriate dose;Behavioral;Cessation of life;Characteristics;Client satisfaction;Clinical;clinical practice;Communities;community setting;Complex;contextual factors;cost effective;Country;Data;deconditioning;Deterioration;disability;Dose;Education;Effectiveness;effectiveness evaluation;Eligibility Determination;Evaluation;Event;experience;functional improvement;Future;Gait speed;Health;Home;hospital readmission;Hospitalization;human old age (65+);implementation context;implementation facilitators;implementation strategy;improved;improved outcome;indexing;innovation;insight;Institutionalization;Instruction;Intervention;Length of Stay;Long-Term Care;Maintenance;Measures;Medical;Methods;muscle strength;Musculoskeletal;Nursing Homes;nursing skill;older adult;Outcome;Patient Admission;Patient Discharge;Patient-Focused Outcomes;Patients;Phase;Physical activity;Physical Function;Physical Performance;Physiological;poor communities;Population;pragmatic randomized trial;pragmatic study;Predictive Factor;pressure;primary endpoint;primary outcome;Process;provider adoption;Quality of Care;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;readmission rates;rehabilitation paradigm;rehabilitation strategy;Rehabilitation therapy;rehabilitative care;Resistance;resistance exercise;Site;Skeletal Muscle;Skilled Nursing Facilities;standard of care;Standardization;success;theories;Therapeutic;Time;Training;treatment as usual;trial design;Variant;Work

PROJECT_TITLE: Advancing Rehabilitation Paradigms for Older Adults in Skilled Nursing Facilities

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative HIV co-infection accelerates liver cirrhosis and liver cancer in chronic hepatitis B virus (HBV) carriers. Our proposed work will establish robust and physiologically relevant primary cell culture systems to study HIV/HBV co-infections. These systems will provide a platform to develop novel antiviral strategies that may lead to a functional HBV cure.

PI_NAMEs: MICHAILIDIS, ELEFTHERIOS  (contact)

PROGRAM_OFFICER_NAME: PTAK, ROGER

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Antigens;antiretroviral therapy;Area;biomarker identification;CD4 Positive T Lymphocytes;Cell Culture System;Cell Line;Cell Separation;Cells;Chronic;Chronic Hepatitis B;chronic infection;Circular DNA;co-infection;Coculture Techniques;curative treatments;Detection;drug development;drug resistance development;e Antigens;Exhibits;Genetic Transcription;Goals;Health;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Vaccines;Hepatitis B Virus;Hepatocyte;hepatoma cell;high risk;HIV;HIV Infections;Human;humanized mouse;Immune response;In Vitro;Individual;Infection;innovation;insight;Interferon alpha;Investigation;Knowledge;Life;Life Cycle Stages;Link;Liver;Liver Cirrhosis;Liver diseases;Maintenance;Malignant neoplasm of liver;Measurement;Messenger RNA;Modeling;Mus;Nature;novel;Nuclear;nucleoside analog;overexpression;Patients;Persons;Physiological;predictive marker;Primary carcinoma of the liver cells;Primary Cell Cultures;prophylactic;Research;response;Risk;RNA;RNA-Directed DNA Polymerase;spheroids;System;Time;transcriptome;transcriptome sequencing;transcriptomics;Viral;Viral Genome;viral rebound;Virus;virus core;Virus Diseases;Virus Receptors;Virus Replication;Withholding Treatment;Work

PROJECT_TITLE: Primary cell culture models of HIV/HBV co-infection

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Tuberculosis remains a leading cause of death around the world, and new treatments are needed to curb the epidemic. This work will help us understand the ways that non- protective immune responses are generated upon infection, allowing disease to be established. We anticipate that this work will facilitate future development of new anti- tuberculosis treatments.

PI_NAMEs: BARCZAK, AMY K (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Antitubercular Agents;arm;Bacteria;biological adaptation to stress;Cause of Death;Cells;Clinical Treatment;Complex;CRISPR/Cas technology;cytokine;Data;Development;Dimensions;Disease;Eicosanoid Production;endoplasmic reticulum stress;Enzyme-Linked Immunosorbent Assay;Epidemic;Equilibrium;Event;Future;Gene Expression Profile;Gene Expression Profiling;Genetic;Genetic Transcription;Growth;Histopathology;Human;human disease;Immune;Immune response;Immunologic Receptors;improved;in vivo;individual response;Infection;Infection Control;Inflammation;Inflammatory Response;Inhalation;innate immune pathways;Innate Immune Response;interest;Interferon Type I;Interferons;Interleukin-1;Knowledge;Link;Lipids;Literature;Lung;Macrophage;Measures;metabolomics;Microscopy;Mitochondria;Modeling;Molecular;mouse model;Mycobacterium tuberculosis;novel;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Patients;Play;Production;Productivity;recruit;response;Role;Sampling;Shapes;Signal Transduction;small molecule;small molecule inhibitor;Testing;Therapeutic;therapeutic target;Tissues;tool;Tuberculosis;tuberculosis treatment;uptake;Western Blotting;Whole Organism;Work

PROJECT_TITLE: Elucidating the path to type I IFNs in TB infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Population science plays a critical role in identifying changing population patterns and their implications for individuals, groups and societies. Increasingly, with new data and analytic techniques, population science can bridge social scientific, biomedical and environmental research in order to better understand the multiple and interactive factors that affect human health and wellbeing. CDE will continue to conduct, develop and disseminate innovative, interdisciplinary population research and to provide excellent training to the next generation of scholars.

PI_NAMEs: CURTIS, KATHERINE J. (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Address;Affect;Area;biodemography;Biological Markers;Collection;college;Communities;Data;Demography;Development;Ecology;Family;Funding;Gender;Genetic;Grant;Health;Human;Individual;Inequality;Infrastructure;innovation;Interdisciplinary Study;Life Cycle Stages;Mission;National Institute of Child Health and Human Development;next generation;Pattern;Personal Satisfaction;Play;Population;Population Dynamics;Population Research;Population Sciences;Poverty;Productivity;programs;recruit;Reproductive Health;Request for Applications;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Role;Scientist;social;Societies;Techniques;Training;Universities;Wisconsin;Work

PROJECT_TITLE: Center for Demography and Ecology


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Comparative Effectiveness Research;Drug Abuse (NIDA only);Methamphetamine;Prescription Drug Misuse;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Many trials for identifying medications for treatment of cocaine and methamphetamine use disorders are too short to achieve sustained abstinence or reduction in drug use, whereas these studies can detect benefits on short-term outcomes such as drug craving. In this project, novel analytic methods will be used to examine the impact of 9 medications on drug craving as a short-term outcome in patients participating in 11 NIDA-sponsored randomized controlled trials for treatments of cocaine and methamphetamine use disorders and to assess the association of craving with other treatment outcomes.

PI_NAMEs: MOJTABAI, RAMIN  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Abstinence;Age;alcohol abuse therapy;alcohol craving;alcohol use disorder;American;analytical method;Baclofen;behavioral phenotyping;Bupropion;cabergoline;candidate identification;Characteristics;Chronic;Clinical;Clinical Treatment;Clinical Trials Network;clinically relevant;Cocaine;Cocaine use disorder;Combination Medication;Combined Modality Therapy;comorbidity;Complex;craving;Data;data harmonization;Dependence;depressive symptoms;Distress;Dropout;drug craving;drug relapse;drug seeking behavior;Drug usage;Effectiveness;Epidemic;Equilibrium;Ethnic Origin;Evaluation;experience;Fatality rate;FDA approved;follow-up;Frequencies;Future;Health;Heterogeneity;Individual;Measures;Mediating;Mediator;Methamphetamine;Methamphetamine use disorder;Modafinil;morphogens;Naltrexone;National Institute of Drug Abuse;nicotine craving;nicotine treatment;Nicotine Use Disorder;novel;Ondansetron;Opioid;Outcome;Overdose;Participant;Patient Participation;patient subsets;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Phase;Probability;prolonged abstinence;Property;psychological distress;Publications;Race;Randomized, Controlled Trials;Recurrence;Relapse;Research;Reserpine;response;Role;Sample Size;Sampling;Selegiline;Severities;sex;Signal Transduction;social;standard of care;Stimulant;stimulant misuse;stimulant use;stimulant use disorder;stimulant user;Structural Models;Subgroup;substance use;Substance Use Disorder;Substance Withdrawal Syndrome;Symptoms;Techniques;tiagabine;topiramate;treatment effect;Treatment outcome;treatment trial;Variant;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Short-term Outcome of Stimulant Use Disorder Treatment Trials

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]