ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative This proposal seeks external funding for a recently launched internship program for Native Hawaiian and Pacific Islander (NHPI) undergraduate students interested in a biomedical career related to improving kidney health. The lack of NHPI representation in health professions contributes, in part, to health disparities observed in these communities (including drastically elevated risk for kidney disease). Our program, named the Haumana 'O Pasifika Program by our inaugural class of 8 Haumana (Hawaiian for "student") Scholars, aims to help outstanding NHPI undergraduates achieve their goals of becoming the next generation of nurses, physician assistants, physicians, and scientists by provide research experience, clinical exposure, career development, and community outreach over the course of a 12-week summer program.

PI_NAMEs: HOLLAND, WILLIAM L (contact);PEZZOLESI, MARCUS GUY;RAPHAEL, KALANI LUKELA

PROJECT_TERMS: Address;African American population;Alaska Native;Alzheimer's Disease;Alzheimer's disease related dementia;American;American Indians;Asian Americans;Asian Pacific Islander;Board Certification;career;career development;Categories;Censuses;Chronic Kidney Failure;Clinical;cohort;Communities;community engagement;Community Outreach;Data;Development;Diabetes Mellitus;diabetes risk;Disparity;Education;Educational Activities;effectiveness evaluation;End stage renal failure;European ancestry;experience;Face;Funding;Goals;hands on research;Hawaiian;Health;health disparity;Health Occupations;Healthcare;high risk;Home;implementation facilitation;improved;Incidence;Individual;Infant Mortality;Information Systems;Institution;interest;Internships;Kidney;Kidney Diseases;Latino Population;Malignant Neoplasms;Masks;Medical;Mentors;minority trainee;Names;Native Americans;Native Hawaiian or Other Pacific Islander;Nephrology;next generation;Nurses;Obesity;Outcome;outreach;Pacific Islander;Physician Assistants;Physicians;Population;Positioning Attribute;programs;Renal Carcinoma;Reporting;Research;research and development;Research Training;Resources;Risk;Scientist;STEM career;Students;summer internship;summer program;summer research;Support System;Time;Training and Education;undergraduate student;United States National Institutes of Health;Universities;Utah

PROJECT_TITLE: Haumana ‘O Pasifika Kidney Program


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: SAN ANTONIO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SOUTH TEXAS VETERANS HEALTH CARE SYSTEM

ORG_STATE: TX

PHR: Posttraumatic Stress Disorder (PTSD) is serious and debilitating, with a particularly negative impact on veterans. Current treatments are inadequate, and there is a need to identify new, more effective approaches. Behavioral therapies, including exposure therapy, can be effective, but little is known of their mechanisms, and efficacy is limited. To address this need, we established extinction learning as a valid model of exposure therapy in rats, then developed a partial, sub-effective extinction procedure to investigate potential adjunct treatments that may enhance the efficacy of exposure therapy. Using this model, the primary purpose of this proposal is to test transcranial direct current stimulation (tDCS), a non-invasive neuromodulatory treatment, as a potential adjunct approach to enhance the efficacy of extinction. Secondly, we will test TB21007, a pharmacological candidate that we believe shares mechanisms with tDCS. The potential impact of this research is to make exposure therapy better and faster, improving treatment outcomes for PTSD, and enhancing quality of life for veterans.

PI_NAMEs: MORILAK, DAVID A (contact)

PROJECT_TERMS: Acceleration;Address;Anatomy;Animals;Anodes;Anxiety;Attenuated;Beds;Behavior;behavior test;Behavior Therapy;behavioral impairment;behavioral study;Brain region;Cell Nucleus;Chronic;Clinical;Cognitive;combat veteran;Combined Modality Therapy;conditioned fear;Coping Behavior;cost;Dimensions;Distress;Dose;Effectiveness;Electrophysiology (science);evidence base;Exposure to;Extinction;flexibility;Fright;Genetic Complementation Test;Grant;Hippocampus;Impaired health;improved;Intervention;Ketamine;Lateral;learning extinction;Measures;Medial;Mediating;Modeling;Monitor;neuroregulation;Painless;Patients;Personal Satisfaction;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Post-Traumatic Stress Disorders;Pre-Clinical Model;Prefrontal Cortex;Procedures;Productivity;Protocols documentation;Pyramidal Cells;Quality of life;Rattus;receptor;Research;response;selective expression;Shock;Stress;Structure of terminal stria nuclei of preoptic region;Symptoms;Testing;Thalamic structure;Therapeutic Effect;transcranial direct current stimulation;treatment duration;treatment effect;Treatment Efficacy;Treatment outcome;Veterans

PROJECT_TITLE: Enhancement of exposure therapy, modeled by extinction learning in rats, using transcranial direct current stimulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 MHBA-U (01)]


ADMINISTERING_IC: AI

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ATHENS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: The relevance of this research to public health: Cryptococcal meningoencephalitis poses a serious threat to public health, causing hundreds of thousands of deaths each year. Cryptococcus neoformans is a fungal pathogen of the top critical priority listed by WHO. There is no clinically available vaccine against Cryptococcus neoformans, and the long-term goal of this project is to identify cryptococcal factors that can induce protective host responses and use these immunogens to develop mRNA-LNP vaccines or recombinant protein vaccines against cryptococcosis.

PI_NAMEs: LIN, XIAORONG  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Animals;Antifungal Therapy;Antigens;Binding;Candida albicans;capsule;CD4 Positive T Lymphocytes;Cell Count;Cell surface;cell type;Cells;Cellular Structures;Cessation of life;Chromatin;Clinical;comparative;Coupled;critical period;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Cytoprotection;Data;Death Rate;Disease;DNA Microarray Chip;DNA sequencing;Drops;Encapsulated;extracellular;Filament;Funding;fungus;genetic approach;Glycoproteins;Goals;GPI Membrane Anchors;Growth;Histocompatibility Antigens Class II;HIV;HIV/AIDS;Immune response;Immunity;immunodeficiency;immunogenicity;Immunotherapy;Individual;Investigation;Link;lipid nanoparticle;Liposomes;Meningoencephalitis;Messenger RNA;Modeling;Molecular;Morphogenesis;Morphology;mouse model;mRNA lipid nano particle vaccine;Mus;Mutation;novel;Opportunistic Infections;overexpression;pathogen;pathogenic fungus;Pathogenicity;Pathway interactions;Patients;Peptides;Persons;Phagocytosis;Phase;preclinical study;prevent;protective effect;protective factors;Proteomics;Public Health;Recombinant Proteins;Regulation;Regulon;Research;Risk;secretory protein;T-Cell Depletion;Technology;Testing;Therapeutic;Time;transcription factor;transcriptome sequencing;Vaccinated;Vaccination;vaccine access;vaccine candidate;vaccine development;Vaccines;Virulence;Virulent;Yeasts;Zinc Fingers

PROJECT_TITLE: Cryptococcal vaccine development based on strong immunity induced by morphological strains

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: Narrative The proposed research is highly relevant to Veterans health, because although cognitive dysfunction is a frequent and persistent symptom of traumatic brain injury (TBI), there are currently no effective treatments available for this persistent deficit. In addition, the neurophysiological basis of these deficits remains unknown, making rational treatment design difficult. This project will therefore define for the first time the underlying functional basis for cognitive dysfunction in biomechanically relevant TBI models with complex behavioral metrics. In addition, advanced neuroimaging that is clinically relevant will be evaluated as a tool for identifying white matter (axonal) disruption relevant to these functional and behavioral deficits. The project is relevant to the VA BLR&D mission because knowledge of why TBI induced cognitive disorders persist, and how neuromodulation alleviates them in relevant animal TBI models of different types of injury, will allow for clinical treatment development that will reduce the burden of these deficits in our Veterans.

PI_NAMEs: WOLF, JOHN ALLEN (contact)

PROJECT_TERMS: Affect;Animal Model;Animals;Area;Axon;axon injury;Behavior;Behavioral;Behavioral Paradigm;Biomechanics;Brain;Brain Injuries;Brain region;Cephalic;Clinical Treatment;clinically relevant;Code;Cognition;Cognition Disorders;Cognitive;cognitive function;Communication;Complex;Coupling;debilitating symptom;density;design;Diffuse;Diffuse Brain Injury;effective therapy;Electrophysiology (science);Episodic memory;experimental study;Failure;Family suidae;Fimbria of hippocampus;Focal Brain Injuries;Functional disorder;functional restoration;Future;Goals;Health;Hippocampus;Human;Imaging Techniques;Impaired cognition;improved;in vivo;Injury;Knowledge;Learning;Measures;Medial;Memory;memory encoding;Memory impairment;memory recall;Methodology;Mission;Modeling;neuroimaging;Neurons;neuropathology;neurophysiology;neuroregulation;novel;Outcome;Pathology;Pathway interactions;Periodicity;persistent symptom;Phase;Play;Population;Prefrontal Cortex;Process;rational design;Research;restoration;Retrieval;Rodent;Series;Short-Term Memory;spatial memory;Structure;Symptoms;System;Techniques;therapy design;therapy development;Time;tool;Translating;Traumatic Brain Injury;treatment strategy;Veterans;white matter;white matter change;white matter injury

PROJECT_TITLE: Functional and Structural Correlates of Cognitive Dysfunction following TBI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURC-H (01)]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NAPERVILLE

ORG_NAME: HUMAN CELL CO

ORG_STATE: IL

PHR: NARRATIVE  The efficacy and mechanism of an optimized human nerve growth factor will be evaluated in a clinically relevant animal model of dry eye disease.

PI_NAMEs: JEONG, SOON SEOG  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Acceleration;Address;Adherence;Affect;Age;Animal Model;Astrocytes;Astrocytosis;Attenuated;Beds;Binding;Blinking;Cholinergic Antagonists;Chronic;Clinical;clinically relevant;conjunctiva;Cornea;corneal epithelium;corneal regeneration;cost;cost effective;Desiccation;design;Devices;digital;Dry Eye Syndromes;efficacy evaluation;efficacy validation;epithelial repair;Epithelium;Escherichia coli;Excision;Eye diseases;eye dryness;Eyedrops;FDA approved;Film;Frequencies;Glaucoma;Goals;healing;Health;Homeostasis;Human;immunoregulation;Immunosuppressive Agents;Impairment;improved;Inflammation;Injury;innovation;Lacrimal gland structure;Mammalian Cell;manufacture;manufacturing cost;Mediating;Modeling;Modification;Mus;Nerve;Nerve Growth Factors;Nerve Plexus;neuron apoptosis;neuronal survival;Neurons;Neuropathy;neurosensory;Neurotrophic Keratitis;Neurotrophic Tyrosine Kinase Receptor Type 1;NGFR Protein;ocular surface;ocular surface disease;Pathogenesis;Pathologic;Pathology;Patients;Permeability;pharmacologic;Phase;Population;preservation;prevent;Process;Production;Proliferating;Proteins;Public Health;Quality of life;Rattus;receptor;Recombinants;repaired;research clinical testing;Retinal Ganglion Cells;Scopolamine;side effect;Signal Transduction;Site;Small Business Innovation Research Grant;Steroids;success;Surface;symptomatic improvement;Symptoms;System;Topical application;translational model;Translations;treatment optimization;Trigeminal nerve structure;tv watching;United States;Vision;visual dysfunction;Work

PROJECT_TITLE: Topical treatment of an optimized NGF for Dry Eye

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-M (12)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Building human resource and infrastructure capacity to enhance sustainability of HIV research discovery and the implementation of findings by a diverse and multidisciplinary workforce is a major goal of the National Institutes of Health’s strategic research plan for HIV and HIV-related research. The proposed five-year program aims to address this public health need by providing research education and mentoring to early- career social and behavioral HIV researchers who have demonstrated cultural expertise, a commitment to improving the health of communities disproportionately affected by HIV, and who are initiating innovative programs of research to advance the program priorities of the NIMH Division of AIDS Research. The core of the program is: an innovative, intensive six-week summer in-residence program of seminars and peer reviews; one-on-one consultations with mentors; research experience funding; ongoing support from mentors and webinars during the academic year; and one-on-one consultations and peer reviews for VP alumni to support them in submitting new NIH grant proposals and remaining in the research pipeline.

PI_NAMEs: ARNOLD, EMILY A;NEILANDS, TORSTEN BRIAN (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Affect;Applications Grants;Applied Research;Area;Articulation;Behavioral;behavioral and social science;behavioral health;California;career;career development;Collaborations;Communities;Community Health;Consultations;Data;Development;Development Plans;Education;education research;Educational Curriculum;Elements;Environment;Epidemic;ethnic minority;experience;faculty mentor;Feedback;flexibility;Fostering;Funding;gender minority;Glean;Goals;Grant;Health Disparities Research;health disparity;HIV;HIV/AIDS;human capital;Human Resources;improved;Individual;Infrastructure;innovation;Literature;Manuscripts;meetings;Mentors;Mentorship;multidisciplinary;National Institute of Mental Health;Participant;peer;peer networks;Peer Review;Peer Review Grants;Persons;Positioning Attribute;Prevention;professor;Program Development;programs;Public Health;Publications;racial minority;Research;research and development;Research Infrastructure;Research Personnel;Research Proposals;Research Training;residence;response;San Francisco;Schedule;Science;Scientist;Secure;sexual minority;social;social capital;Strategic Planning;Structure;Suggestion;summer institute;symposium;System;theories;Training;Training and Infrastructure;Training Programs;United States National Institutes of Health;Universities;Visit;webinar;Work;Writing

PROJECT_TITLE: Training for Scientists Conducting Research to Reduce HIV/AIDS Health Disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (03)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Regenerative Medicine

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE The adult brain shows limited plasticity, which poses a challenge for learning new tasks in health, and for repairing neuronal connections after injury such as stroke, or in neurodegenerative disorders such as Alzheimer’s disease. Most current approaches to increase plasticity cause permanent alteration of neuronal state, with potential for detrimental outcomes, therefore new approaches are needed to transiently alter neuronal plasticity state to enable controlled synaptic remodeling and repair. This is achieved by developing Targeted Degradation of Extracellular Proteins (TDEP), a toolkit of genetic reagents to enable precise control of the neuronal environment to promote brain health and repair that can be applied to multiple neurological disorders where enhancing synaptic plasticity would be beneficial.

PI_NAMEs: ALLEN, NICOLA J (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acute;Adult;Alzheimer's Disease;Area;Astrocytes;Atlases;Binding Proteins;Biological Assay;Biotin;Brain;brain cell;brain health;brain repair;candidate identification;Coupled;Environment;Enzymes;Excision;Extracellular Protein;Extracellular Space;functional improvement;functional restoration;Genetic;Goals;Health;Injury;interest;Label;Lead;Learning;Memory;Modeling;nanobodies;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;neuronal circuitry;Neuronal Plasticity;Neurons;Neurosciences;novel strategies;Outcome;Protein Biosynthesis;protein degradation;Protein Secretion;Proteins;Reagent;repaired;Repression;Role;Source;Stroke;Synapses;Synaptic plasticity;System;uptake;Visual System

PROJECT_TITLE: Targeted Degradation of Extracellular Proteins to Enhance Brain Plasticity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-J (70)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Contraception/Reproduction;Neurosciences;Pain Research;Women's Health Research

ORG_NAME: THERANOVA, LLC

PHR: Narrative Dysmenorrhea is a painful condition affecting up to 90% of women and people with uteruses and is defined by cramping-associated pain during menstruation. Non-steroidal anti-inflammatory drugs (NSAIDs) and hormonal contraception (HC) are first-line options for treating dysmenorrhea, but with 20-25% of people not responding to NSAIDs and many finding the side effects of NSAID and HC use to be unacceptable, the overall impact of these therapies is limited. This Phase I SBIR project proposes the clinical evaluation of a non-invasive transcutaneous electrical nerve stimulation device to provide an at-home treatment for dysmenorrhea.

PI_NAMEs: BURNETT, DANIEL ROGERS (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: active method;Acupuncture Points;Acupuncture Therapy;Address;Affect;analog;Ankle;Caring;Clinic;Clinical Research;Clinical Trials;commercialization;daily pain;design;Development;Devices;Distress;Dysmenorrhea;Economic Burden;effective therapy;Effectiveness;Electroacupuncture;Electrodes;feasibility testing;foot;foot sole;Gel;Goals;High Prevalence;Home;hormonal contraception;Hour;improved;Location;Medical;Menstrual cycle;Menstruation;Muscle Cramp;myometrium;Nerve;neuroregulation;Non-Steroidal Anti-Inflammatory Agents;Numeric Rating Scale;older adult;Overactive Bladder;Pain;pain reduction;pain scale;pain score;pain sensation;Participant;Pathology;Pathway interactions;Patient Self-Report;Patients;Pelvic floor structure;Pelvis;Peripheral Nerve Stimulation;Peripheral Nerves;Persons;Phase;Placebos;portability;Posterior Tibial Nerves;pressure;prevent;Quality of life;Questionnaires;Randomized;randomized, controlled study;Reporting;research clinical testing;Safety;satisfaction;Schedule;Schools;Self Administration;sham-controlled study;side effect;Signal Transduction;Small Business Innovation Research Grant;Surveys;Symptoms;System;Technology;Transcutaneous Electric Nerve Stimulation;Translating;Treatment Effectiveness;usability;Uterine Contraction;Uterus;Visual;Woman;Work

PROJECT_TITLE: SoleStim Neuromodulation System, a home-use device for the treatment of dysmenorrhea

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-J (10)]


NIH_SPENDING_CATS: Chronic Pain;Contraception/Reproduction;Endometriosis;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse;Women's Health Research

ORG_CITY: EXTON

ORG_NAME: SERENTRIX, LLC

PHR: Project Narrative TRPV1 antagonist-based pharmaceuticals represent a completely new approach to treating pain associated with endometriosis. Based on the published literature supporting this target in the pathophysiology of pain and the preclinical and clinical work completed thus far by Serentrix, we are confident that we will be able to demonstrate that SER-014 is a highly efficacious and safe treatment for pain associated with endometriosis. Together, the package of aforementioned studies will demonstrate the pharmacology and safety of selective antagonism of the TRPV1 receptor. These studies will also lay the groundwork for the future clinical development of this compound for pain associated with endometriosis.

PI_NAMEs: BHARGAVA, KUMARIL  (contact)

PROJECT_TERMS: Ablation;Absence of pain sensation;Acids;addiction liability;Adverse effects;Affect;Afferent Neurons;Age;Agonist;Analgesics;Animals;antagonist;Biotechnology;Blood;Body Temperature;Calcium Channel;Calcium Signaling;Capsaicin;Cations;Cells;Chronic;chronic pain management;Clinical;clinical development;Clinical Trials;Collaborations;comorbidity;Data;debilitating pain;Development;Disease;disease model;Dose;Endometrial;endometriosis;Endometrium;Excision;Exercise;experience;experimental study;Female;female reproductive tract;Fibroblasts;Flare;Functional disorder;Future;Generations;Goals;Gonadotropin-Releasing Hormone Receptor;Growth;Guidelines;Gynecologic;Health Care Costs;heat injury;Helping to End Addiction Long-term;Histology;Hormonal;hormone therapy;Human;human subject;Hyperthermia;improved;In Vitro;Induced Hyperthermia;Infiltration;Inflammation;Inflammatory;inhibitor;innovation;Investments;irritation;Lead;Legal patent;Lesion;Literature;Measurement;Measures;Mediating;Mediation;Mediator;Medical;Medical center;medical schools;member;Modeling;Molecular;mouse model;Mus;Nerve;Neurons;Non-Steroidal Anti-Inflammatory Agents;novel;novel strategies;Operative Surgical Procedures;Opiate Addiction;Opioid;opioid overdose;opioid use;Pain;Pain management;pain relief;Pain Research;Patients;PC12 Cells;Pediatric Hospitals;Perception;Peripheral;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Phase I Clinical Trials;phase I trial;Phase II Clinical Trials;pre-clinical;preclinical development;Proteins;Protons;Publishing;Quality of life;receptor;Recording of previous events;Recurrent pain;reduce symptoms;reproductive;reproductive tract;Research;response;Rights;Safety;Sensory;side effect;Signal Transduction;small molecule;social engagement;Specificity;spontaneous pain;steroid hormone receptor;Technology;Temperature;Testing;therapy development;Time;Tissues;TRPV1 gene;Underserved Population;Universities;Up-Regulation;Uterus;Vanilloid;Woman;Work

PROJECT_TITLE: Validating SER-014, a TRPV1 antagonist, to treat endometriosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-S (14)]


ADMINISTERING_IC: PS

IC_NAME: NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STD AND TB PREVENTION

PHR: PROJECT NARRATIVE This study will support the expansion of long-acting injectable antiretroviral therapy (LAI-ART) in non-clinical settings by developing, implementing, and evaluating a comprehensive, theory-informed training intervention to support the administration of LAI-ART by a trained layperson injector (e.g., friend, family, partner identified by a person living with HIV). This study will address barriers to LAI-ART uptake and persistence, enhance real- world effectiveness, and help close critical HIV care gaps.

PI_NAMEs: SABERI, PARYA  (contact)

PROJECT_TITLE: RFA-PS-23-004, Innovative Administration of Long-Acting Injectables for HIV Treatment Enhancement at Home (INVITE-Home)


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: HSU, HSUN-TA  (contact)

PROJECT_TITLE: CE-22-004 Research Grants to Prevent Firearm-Related Violence and Injuries (R01) - 2022


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Efforts to curb the HIV epidemic in the United States (US) are impeded by suboptimal access and adherence to antiretroviral therapy (ART), particularly among cis-gender Black women with HIV (CgBWH) in the US South who face intersectional constraints that limit their progression along the HIV care continuum. Long-acting (LA) ART has the potential to transform the landscape of HIV treatment and serve as a tool to help end the epidemic, but to maximize its potential we must develop innovative and tailored approaches to facilitate care linkage and adherence strategies for marginalized populations across rural and urban settings, including CgBWH. In this proposed U01, our multidisciplinary team will leverage existing academic-community partnerships to conduct a mixed methods study that integrates CgBWH LA ART preferences, barriers, and facilitators with qualitative data from HIV service providers on implementation strategies to co-create tailored prototype tools for LA ART education, linkage and referral that will support CgBWH access and uptake across delivery sites.

PI_NAMEs: COLLINS, LAUREN FRANCES (contact)

PROJECT_TITLE: PS23-003 - A Community-based Assessment of Preferences for Long-Acting Antiretroviral Therapy Options Among Cis-gender Black Women across Six Ending the HIV Epidemic Jurisdictions in the South


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Polysubstance use (PSU) and concomitant overdose are substantial public health issues, with over half of overdose deaths nationally involving multiple substances. The proposed research aims to address two key facets of overdose prevention centers (OPCs), a novel harm reduction intervention, as they relate to overdose risk and mental health in PSU-involved populations: (1) the capacity for OPCs to reduce overdose mortality and morbidity for this high-risk population and (2) the potential role of OPCs as a venue to address mental health needs of PSU-involved populations. This K01 will uncover evidence to support the optimization of an emerging public health intervention as it scales nationally in the context of an ongoing polysubstance overdose epidemic and support a new investigator in developing an independent research career dedicated to building equitable and integrated access to substance use and mental health services to prevent overdose.

PI_NAMEs: ALLEN, BENNETT  (contact)

PROJECT_TITLE: CE23-002 - Assessing the Impact of Overdose Prevention Centers as a Polysubstance Use and Behavioral Health Intervention in New York City


ADMINISTERING_IC: IP

IC_NAME: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Component A: Project Narrative Conducting year-round, prospective surveillance for well-established and newly emergent gastrointestinal and respiratory diseases will provide vital information about the burden of these illnesses in pediatric patients seeking care in the emergency room and who are hospitalized. With with information, CDC will have the information needed to determine the impact of current vaccines, new vaccines, antiviral treatments, and maternal vaccination on these pediatric infectious diseases. CDC will also be able to correlate the incidence of these infections in children and the development of new clinical diseases such as acute flaccid myelitis.

PI_NAMEs: BOOM, JULIE ANNE (contact);SAHNI, LEILA C

PROJECT_TITLE: IP21-002, Surveillance for Vaccine Preventable Disease in Children


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Nutrition;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE This pragmatic randomized controlled trial will assess the efficacy of medically tailored meals and medical nutrition therapy via telehealth on clinical outcomes for patients with poorly controlled type 2 diabetes. The goal of these interventions is to improve outcomes for patients with diabetes by impacting self-care behaviors and diet self-efficacy in the short and long term. This study leverages a unique health system and community group partnership to inform the utility of reimbursement for medically tailored meal programs and medical nutrition therapy, which would ultimately facilitate their scalability and sustainability within the healthcare system.

PI_NAMEs: RISING, KRISTIN LAURA (contact)

PROGRAM_OFFICER_NAME: RAJAPAKSE, NISHADI

PROJECT_TERMS: Address;African American;African American population;American;arm;Behavior;care costs;care delivery;Cause of Death;Chronic Disease;Client satisfaction;Clinical;Clinical Trials;Collaborations;Communities;comparison intervention;Cost Analysis;cost effectiveness;Counseling;Data;Decision Making;diabetes management;Diabetes Mellitus;Diet;Diet and Nutrition;Disadvantaged;Disease Management;Disparity;disparity reduction;effectiveness evaluation;efficacy evaluation;evidence base;experience;Food;Food Access;Food Services;glycemic control;Glycosylated hemoglobin A;Goals;Health;Health Care Costs;health care service utilization;Health Food;Health system;Healthcare Systems;High Prevalence;high risk;Improve Access;improved;improved outcome;Individual;innovation;interest;Intervention;Low income;Measures;Medical;Medical Nutrition Therapy;Medicine;Modeling;Non-Insulin-Dependent Diabetes Mellitus;Nonprofit Organizations;novel;nutrition;nutrition education;Outcome;outcome disparities;patient oriented;patient population;patient responsibilities;Patient-Focused Outcomes;patient-level barriers;Patients;personalized nutrition;Persons;Pilot Projects;primary outcome;programs;Provider;Public Health;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;routine practice;Schedule;secondary outcome;Self Care;Self Efficacy;Services;Structure;success;System;telehealth;Telemedicine;Testing;Therapeutic Intervention;treatment arm;treatment as usual;Treatment Failure;uptake;Visit;Weight;Work

PROJECT_TITLE: A pragmatic randomized controlled trial assessing the impact of medically tailored meals and medical nutrition therapy via telehealth among patients with poorly controlled diabetes


ADMINISTERING_IC: DA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: RELEVANCE AND NARRATIVE (Overall) Overall Relevance The actions of abused drugs on the brain lead directly to many of the nation’s and the world’s greatest public health problems, yet the nature of the drug-altered brain is very poorly understood. We believe that this fact is relevant to the present situation in which available treatments and preventions are inadequately effective for most people and that an effective path to developing treatments and cures is opened up via deeper understanding of underlying circuit dynamics, which will be addressed here. Narrative In this project, the Center will 1) Bring together a diverse set of investigators for the important goal of understanding, both brainwide and at cellular resolution, the causal circuit dynamics of abused drug action; 2) Develop a broad range of new approaches for studying the actions of drugs of abuse on the brain; 3) Apply these approaches, collaboratively under the Center, to circuit dynamics of both acute and chronic abused- drug action; 4) Disseminate the resulting technologies to the drug abuse and supporting scientific communities through a unique and innovative training/educational program.

PI_NAMEs: DEISSEROTH, KARL A. (contact);GIOCOMO, LISA

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Acute;Address;Animals;Basic Science;Behavior;Behavioral;Brain;Cells;Chronic;Clinical;clinically significant;Cognition;Cognitive;Collaborations;Communication;Communities;Decision Making;Dedications;design;Development;Disease;Drug abuse;drug action;Drug Modulation;drug of abuse;ecstasy;Education;Education and Outreach;entorhinal cortex;Experimental Designs;Functional Imaging;Goals;Hippocampal Formation;Human;Individual;innovation;Investigation;Ketamine;Lead;Mediating;Methamphetamine;Molecular Profiling;Mus;National Institute of Drug Abuse;Nature;nature center;Nervous System;neural circuit;next generation;novel;novel strategies;outreach;Perception;Persons;Pharmaceutical Preparations;pharmacologic;Physiology;Population;Prevention;Process;programs;Property;Public Health;Research;Research Personnel;Research Project Grants;Resolution;Rewards;Risk;Rodent;Science;social;spatiotemporal;Specificity;structural imaging;Structure-Activity Relationship;Synapses;System;Techniques;Technology;Text;Thinking;Training;Training and Education;Translations;Vision

PROJECT_TITLE: Neural circuit dynamics of drug action:revealing, uncoupling, and restoring altered brain states


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: DEISSEROTH, KARL A. (contact)

PROJECT_TERMS: Accounting;Administrative Coordination;Animals;Brain;Caring;Charge;clinical center;Communication;Communities;Complex;cost effective;data dissemination;Data Set;data sharing;data streams;Deposition;Drug abuse;drug action;Drug usage;Education;Educational process of instructing;Electrical Engineering;Elements;experience;Goals;graduate student;Human;Human Resources;Human Subject Research;Infrastructure;Ion Channel;Ion Pumps;Laboratories;Light;Logistics;Measures;meetings;member;National Institute of Drug Abuse;neural circuit;Neurosciences;next generation;Occupational activity of managing finances;outreach;Persons;Postdoctoral Fellow;Progress Reports;Protocols documentation;Psychiatry;Publications;Reagent;Regulation;Reporting;Research;Research Personnel;Resources;Safety;Safety Management;Schedule;Science;Scientist;Shipping;Shoulder;Site;Source Code;Subgroup;success;Technology;Training;Training Activity;Universities;University resources;vector;Visit;web page;wiki

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: QUIRIN, SEAN ALBERT (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adult;Anatomy;Attention;Axon;Back;Behavior;Behavioral;Brain;Brain region;brain volume;cell type;Cells;Chemistry;Collaborations;Communities;data streams;design;Development;Devices;Diameter;Disease;dopaminergic neuron;Drug abuse;drug action;Drug Modulation;drug of abuse;Elements;Equipment;experience;experimental study;Fiber;Goals;Head;Health;Hydrogels;Image;Individual;insight;Investigation;Joints;Light;Link;Mammals;Maps;member;Methods;Microscope;Modeling;Molecular;Motor;National Institute of Drug Abuse;Neocortex;neural;neural circuit;Neurons;Neurosciences;new technology;next generation;Noise;Optics;optogenetics;Organism;Photometry;Population;preservation;Process;real world application;Research;Research Project Grants;Resolution;Rodent;Scientist;Sensory;Signal Transduction;single-cell RNA sequencing;Site;Specific qualifier value;Speed;Structure;Structure-Activity Relationship;Technology;technology validation;Tissues;tool;Training;transcriptomics;two-photon;Ventral Tegmental Area;Visit

PROJECT_TITLE: Technology Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Emerging Infectious Diseases;Infectious Diseases;Influenza;Obesity;Pneumonia and Influenza;Prevention

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: We hypothesize that local inflammatory events in the respiratory system from influenza virus infection  leads to systemic changes in normal cardiovascular physiology that can be altered with bodyweight and  timely admission of antiviral therapeutics. Changes in cardiovascular physiology, biomarkers, and viral  genomic heterogeneity will be investigated from onset to recovery in influenza infection in mice with  obesity and antiviral prophylaxis or treatment.

PI_NAMEs: MARTIN, BRIGITTE  (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Admission activity;Anti-Inflammatory Agents;Anti-viral Agents;Biological Markers;Body Weight;Cardiovascular Physiology;Cardiovascular system;Chemoprophylaxis;Disease;Event;expectation;Genomics;Health;Heterogeneity;Homeostasis;improved;Infection;Inflammatory;Influenza;influenza infection;Investigation;Knowledge;Molecular;Mus;novel marker;Obese Mice;Obesity;Oseltamivir;pathogen;Peripheral;Physiological;Population;Prophylactic treatment;Proteomics;Recovery;respiratory;respiratory infection virus;Respiratory System;response;Site;spatiotemporal;Viral;viral genomics;Viral Respiratory Tract Infection

PROJECT_TITLE: Host-pathogen molecular and cardiovascular interaction during influenza infection


PI_NAMEs: LO, MAISIE KY (contact)

PROJECT_TERMS: 3-Dimensional;Acrylamides;Alzheimer's Disease;Anatomy;autism spectrum disorder;awake;Behavior;Behavioral;Biological;Brain;brain tissue;career;Categories;Cells;Charge;Chemistry;Communities;cost;design;Devices;Drug abuse;drug action;drug of abuse;dynamic system;Education;Educational workshop;Electrophysiology (science);Elements;Excision;Fertilization;Fiber;Fiber Optics;free behavior;Genes;Genetic;Goals;Human;Human Resources;Hydrogels;in vivo;Infrastructure;interest;Intervention;Intramural Research Program;Label;Laboratories;Lasers;Learning;Light;Link;Mental Depression;Methods;microbial;millisecond;Mission;Modeling;Modernization;Molecular;Multiple Sclerosis;National Institute of Drug Abuse;Nervous System;neural circuit;Neurons;Neurosciences;next generation;Opsin;Optics;optogenetics;outreach;Paper;Parkinsonian Disorders;Participant;Pharmaceutical Preparations;Photometry;Polymers;Positioning Attribute;pre-clinical;Recovery;Research;Research Personnel;Resolution;Rodent;Scientist;Series;Structure;success;Technology;Time;Tissues;tool;Training;Training and Infrastructure;transcriptomics;Variant;Vision;Visit;Work

PROJECT_TITLE: Training Core


PROJECT_TERMS: 3-Dimensional;Accounting;Acute;Affective;Animals;Area;Aversive Stimulus;awake;Behavior;Behavioral;behavioral response;Brain;Cells;Chemistry;Chronic;clinically significant;Communities;Dependence;Desire for food;Development;Dissociation;Drug abuse;drug action;Drug Modulation;drug of abuse;dynamic system;ecstasy;Elements;Epidemiology;Etiology;experimental study;Exposure to;Extramural Activities;Fiber;Foundations;Funding;Hydrogels;Image;Individual;insight;Intervention;Investigation;Ketamine;Link;Maps;Measures;Methamphetamine;Methods;Molecular;National Institute of Drug Abuse;neural;neural circuit;Neurons;novel;Opioid;optogenetics;Outcome;Pathway interactions;Pattern;Perception;Pharmaceutical Preparations;Photometry;Physiologic pulse;Play;Population;Predisposition;Prevention;Productivity;Program Description;Property;Publishing;Reagent;Research;Resolution;Rewards;Risk;Rodent;Sensory;Specificity;Substance abuse problem;synergism;Technology;temporal measurement;Testing;Thalamic Nuclei;Therapeutic;therapeutic target;Tissues;tool;Training;transcriptomics;Work

PROJECT_TITLE: Single-cell causality in origination, propagation, and resolution of drug-altered brain states


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetic Testing;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Inborn errors of immunity (IEI) are genetic disorders of the immune system affecting over 400 genes, with new defects discovered at a rapid rate. As the IEI gene panels, WES, and WGS sequencing are increasingly used, about 75% of IEI sequencing yields no diagnostic variants, but do yield variants of unknown significance (VUSs) in one of there 400 genes or novel candidate genes, which require functional characterization for definitive genetic diagnosis. We propose to build a regional resource which will lead to an increase in diagnostic rate and an expansion of research enterprises with clinically significant biological questions.

PI_NAMEs: BOGUNOVIC, DUSAN ;MILNER, JOSHUA D. (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Affect;Artificial Intelligence;Back;Bioinformatics;Biological;Biological Assay;Blood specimen;Bone Marrow Involvement;Bone Marrow Transplantation;Candidate Disease Gene;Caring;causal variant;central database;Classification;Clinical;clinical care;clinically relevant;clinically significant;cohort;Collaborations;congenital immunodeficiency;Consent;Data;data submission;Databases;Defect;Diagnosis;Diagnostic;Disease;disease-causing mutation;DNA;Educational process of instructing;Evaluation;feeding;functional outcomes;Future;gene discovery;gene therapy;Genes;Genetic;genetic analysis;Genetic Counseling;Genetic Databases;Genetic Diseases;genetic disorder diagnosis;genetic variant;Genetic Variation;genome sequencing;Genomics;Genotype;High-Throughput Nucleotide Sequencing;Immune System Diseases;Immunologics;Immunology;Individual;Insurance;Laboratory Research;Machine Learning;Medicine;multidisciplinary;New York;novel;Patients;Phenotype;Physicians;Population;precision medicine;Prevalence;Price;Process;Production;Provider;provider portal;Publications;Recommendation;Reporting;Research;Resources;Review Committee;Scientist;systematic review;Time;Tissue Sample;Triage;Validation;Variant;variant of unknown significance;web portal;Work

PROJECT_TITLE: New York Regional Inborn Errors of Immunity Resource Initiative League (NY-ROYAL)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative (Overall) The overarching hypothesis of this SPORE proposal is that combining RT with systemic therapy that targets the molecular drivers of locally advanced cancers will improve the outcome of treatment. We do not know of another group that can carry out integrated preclinical and clinical studies which have a significant chance of decreasing the morbidity and mortality of breast, brain, and pancreas cancer by increasing the RT sensitivity and immunogenicity of tumors through targeting their molecular drivers using clinically available agents.

PI_NAMEs: LAWRENCE, THEODORE S (contact);MORGAN, MEREDITH A

PROGRAM_OFFICER_NAME: SCROGGINS, BRADLEY TODD

PROJECT_TERMS: Address;advanced pancreatic cancer;Animals;Astrocytes;Biological Assay;bioluminescence imaging;Biometry;Breast Cancer Cell;cancer type;CDK4 gene;Cell Cycle Regulation;Clinical;Clinical assessments;Clinical Research;Clinical Trials;Combined Modality Therapy;Computational Biology;Conformal Radiotherapy;Correlative Study;Cytoplasm;Data;Disease;DNA;DNA Damage;DNA Repair;Dose;early phase trial;Estrogen receptor positive;FDA approved;Future;Glioblastoma;Glutamine;Goals;Guanosine Triphosphate;immune checkpoint blockade;immunogenicity;improved;improved outcome;In Vitro;in vivo;individual patient;inhibitor;Institution;Interferons;Knowledge;Locally Advanced Malignant Neoplasm;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of pancreas;Malignant Neoplasms;Metastatic breast cancer;Microscopic;Molecular;Molecular Target;molecular targeted therapies;Morbidity - disease rate;mortality;Mus;mycophenolate mofetil;neoplastic cell;Normal tissue morphology;Operative Surgical Procedures;Outcome;PARP inhibition;Pathology;Patients;pharmacologic;Phase Ib Clinical Trial;phase II trial;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;precision medicine;preclinical study;Preclinical Testing;Primary Neoplasm;programmed cell death ligand 1;protein function;Purines;Radiation;Radiation Induced DNA Damage;radiation resistance;Radiation therapy;Radiation Tolerance;Radiation Toxicity;Radiosensitization;randomized trial;Recording of previous events;Reporter;Research;Resistance;response;Retinoblastoma Protein;Signal Transduction;standard care;success;Systemic Therapy;Testing;Translations;Treatment outcome;triple-negative invasive breast carcinoma;tumor;tumor metabolism;Unresectable;women's treatment;Work;X-Ray Computed Tomography

PROJECT_TITLE: Molecularly Targeted Radiosensitization of Locally Advanced Cancers


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Radiation Oncology

PHR: PROJECT NARRATIVE (ADMINISTRATIVE CORE) Through its interactive organizational structure including clearly defined leadership and advisory capabilities the Administrative Core of the University of Michigan Radiosensitization SPORE supports all projects, cores, and developmental programs of the SPORE. The Administrative Core fosters in-depth communication among all SPORE components to enhance research integration, provide critical scientific feedback, evaluate scientific progress, plan for future opportunities, and assert translational focus. The Core communicates with the National Cancer Institute staff and helps its scientists disseminate their findings rapidly to the public.

PI_NAMEs: LAWRENCE, THEODORE S (contact)

PROJECT_TERMS: Accountability;Biometry;Cancer Center;Cancer Patient;cancer prevention;cancer risk;cancer therapy;Clinical;Clinical Research;Clinical Trials;Communication;Community Outreach;Computational Biology;Data;Data Management Resources;Development;Ensure;Evaluation;Feedback;flexibility;Fostering;Future;Health;health disparity;Individual;innovation;Institution;Leadership;Locally Advanced Malignant Neoplasm;Malignant Neoplasms;Manuscripts;member;Michigan;Molecular Target;National Cancer Institute;Office of Administrative Management;organizational structure;Patients;Policies;Population;Preparation;Process;programs;Radiosensitization;Regulation;Research;Research Activity;Research Personnel;Resource Informatics;Resources;Schools;Scientist;Structure;Translational Research;Translations;underserved minority;United States National Institutes of Health;Universities;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: GIOCOMO, LISA  (contact)

PROJECT_TERMS: Acute;Animals;Behavior;Behavioral;Brain;brain behavior;Brain region;Cell Nucleus;Code;Cognition;Cognitive;cognitive process;Complex;Dissociation;drug action;Drug Addiction;drug of abuse;drug seeking behavior;Drug usage;Electrophysiology (science);entorhinal cortex;Environment;experience;Genetic;HCN1 channel;HCN1 gene;Hippocampus;hypnotic;Impairment;in vivo;insight;interest;Ketamine;Knock-out;Knockout Mice;Left;Link;Location;Long-Term Effects;Measures;Medial;Memory;Methamphetamine;Molecular;Molecular Target;Morphine;Movement;Mus;Nature;neural;neural circuit;neural correlate;Neurons;NR2A NMDA receptor;operation;Parietal;Persons;Pharmaceutical Preparations;Physiological;Positioning Attribute;Prevalence;Property;psychologic;Relapse;response;Rewards;Running;Site;Space Perception;spatial memory;Speed;System;Techniques;Technology;Therapeutic;Therapeutic Agents;Training;Update;Viral;virtual reality environment;Visual;way finding;Work

PROJECT_TITLE: Brain-wide circuits for drug-induced changes to cognition


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

PHR: NARRATIVE (PROJECT 1) Pancreatic cancer is the third leading cause of cancer-related death in the United States and is associated with a grim 10% 5-year survival rate. The overall goal of this application is to develop a therapeutic strategy using the combination of radiation with the FDA approved agent olaparib to sensitize the majority of otherwise resistant pancreatic cancers to immunotherapy. The preclinical and clinical studies in this proposal will lead to urgently needed advances in the clinical management of locally advanced pancreatic cancer.

PI_NAMEs: MORGAN, MEREDITH A (contact)

PROJECT_TERMS: adaptive immune response;adaptive immunity;advanced pancreatic cancer;Agreement;anti-PD-L1;Biopsy;Blocking Antibodies;Blood;Cancer Etiology;CD8-Positive T-Lymphocytes;Cell Survival;Cells;Cessation of life;chemotherapy;clinical investigation;Clinical Management;Clinical Research;Clinical Trials;Combined Modality Therapy;Data;Dependence;design;DNA;DNA biosynthesis;DNA Damage;Dose;Dose Limiting;ds-DNA;Event;FDA approved;fractionated radiation;Fractionation;gastrointestinal;Generations;Goals;homologous recombination;Immune;immune checkpoint blockade;Immunocompetent;immunodeficiency;immunogenicity;immunoregulation;Immunotherapy;improved;inhibitor;innate immune mechanisms;Innate Immune Response;Interferon Type I;Lesion;Localized Disease;Locally Advanced Malignant Neoplasm;Malignant neoplasm of pancreas;Mediating;Methods;Micrometastasis;micronucleus;Molecular;Molecular Target;Natural Immunity;neoplastic cell;novel;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;PARP inhibition;Pathway interactions;Patients;Pattern recognition receptor;Phase;Phase I/II Trial;phase II trial;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;preclinical study;programmed cell death ligand 1;Property;Radiation;Radiation Dose Unit;Radiation Induced DNA Damage;Radiation therapy;Radiation-Sensitizing Agents;Radiosensitization;Randomized;replication stress;Resistance;response;Schedule;Site;Stimulator of Interferon Genes;subcutaneous;Survival Rate;synergism;T-Cell Depletion;Therapeutic;Therapeutic Index;time use;Toxic effect;Translating;Treatment Efficacy;Treatment outcome;tumor;tumor DNA;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;United States

PROJECT_TITLE: Project 1: Combining PARP inhibition with radiation to sensitize HR proficient pancreatic cancers to immunotherapy


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: MEYER, SARA E (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Affect;Agonist;Binding;Biotinylation;cell growth;Characteristics;chemokine;Chemoresistance;Child;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;CXCL9 gene;cytokine;Cytotoxic Chemotherapy;Data;Dependence;Disease;DNA;DNA Methylation;DNA Modification Methylases;DNMT3a;DNMT3a mutation;Epigenetic Process;Event;Exhibits;FLT3 gene;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;genomic locus;Growth;Hematopoietic Neoplasms;Hematopoietic stem cells;high risk;Human;Immune signaling;in vivo;innovation;IRAK4 gene;leukemia;leukemia initiating cell;leukemic stem cell;leukemic transformation;leukemogenesis;loss of function;Maintenance;Messenger RNA;Methyltransferase;MicroRNAs;mouse model;Mus;mutant;Mutation;Myelogenous;Myeloid Leukemia;novel;Outcome;Output;overexpression;Pathogenesis;Patients;Phosphotransferases;Receptor Protein-Tyrosine Kinases;Receptor Signaling;RELA gene;Repression;restoration;self-renewal;Signal Transduction;stemness;Testing;Therapeutic;therapeutic evaluation;TLR7 gene;Toll-Like Receptor Pathway;Toll-like receptors;Untranslated RNA

PROJECT_TITLE: Integration of epigenetic and non-coding RNA mechanism in leukemia


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Kidney Disease;Primary Health Care

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE We propose to conduct a randomized controlled trial comparing treat to target serum urate with treat to avoid symptoms among patients with gout and hyperuricemia. We anticipate that a treat to target serum urate strategy results in significantly fewer gout flares (primary outcome) over a two-year follow-up. We will also test the effects of lowering serum urate on kidney disease endpoints, glycemic status, and blood pressure among relevant subgroups of patients with gout enrolled in the randomized controlled trial.

PI_NAMEs: BARRY, MICHAEL J;CHOI, HYON K (contact);SOLOMON, DANIEL HAL

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adult;Affect;Agreement;American;American College of Physicians;arm;Arterial Fatty Streak;Arthritis;arthropathies;biobank;Blinded;Blood Pressure;bone erosion;burden of illness;Cardiac;Cardiology;cardiovascular risk factor;Cardiovascular system;Caring;Cessation of life;Cholesterol;Chronic;Chronic Kidney Failure;Clinical;Clinical Trials;cohort;Conflict (Psychology);Consensus;Coronary artery;cost effective;Crystal Formation;Data;Deposition;Diabetes Mellitus;Disabling;Enrollment;Ensure;Equipoise;evidence base;Flare;follow-up;Funding;Genetic;Glomerular Filtration Rate;glycemic control;Glycosylated hemoglobin A;Gout;Guidelines;high risk;Hyperuricemia;improved;incremental cost;Inflammasome;Inflammation;Inflammatory;Inflammatory Arthritis;Infrastructure;insight;interest;Intervention;joint injury;Kidney;Kidney Diseases;Letters;Level of Evidence;Measures;Metabolic;Methods;Myocardial Infarction;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nephrology;Nurse Practitioners;Nurses;Outcome;Pain;participant enrollment;Pathway interactions;Patient Recruitments;patient subsets;Patients;Phenotype;Physician Assistants;Play;premature;primary care practice;primary care provider;primary outcome;Procedures;Protocols documentation;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Recruitment Activity;renal damage;Renal function;Reporting;Research Personnel;Resources;rheumatologist;Rheumatology;Risk;Role;Running;Science;screening;Serum;Site;Specialist;Subgroup;Surrogate Markers;symposium;Symptoms;Testing;trial comparing;United States National Institutes of Health;Urate;Visit;Work;X-Ray Computed Tomography

PROJECT_TITLE: Treat-to-Target Serum Urate versus Treat-to-Avoid Symptoms in Gout: A Randomized Controlled Trial (TRUST)

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC(10)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Prescription Drug Misuse;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: MALENKA, ROBERT C (contact)

PROJECT_TERMS: abuse liability;Affinity;Algorithms;Amphetamine Abuse;amphetamine use;Amphetamines;Anatomy;Behavior;Behavioral;Biological Assay;Brain;Brain imaging;Brain Mapping;Brain region;candidate identification;Cardiovascular system;Cells;Chemicals;Collaborations;comparative;defined contribution;Detection;Disease;Dopamine;dopamine transporter;drug action;Drug Controls;drug reward;ecstasy;electrical property;Elements;Empathy;experience;Experimental Designs;experimental study;Feeling;Fostering;Future;Genetic Recombination;Human;human imaging;human subject;imaging modality;Immediate-Early Genes;in vivo;in vivo imaging;interest;Ligands;Light;Link;loss of function;Maps;Mediating;Methamphetamine;methamphetamine action;Microscopy;millisecond;Modeling;Molecular;multimodality;Mus;neural;neural circuit;neural patterning;neuroimaging;neuronal patterning;Neurons;neuropsychiatry;novel;novel therapeutic intervention;Nucleus Accumbens;optogenetics;Pattern;Pharmaceutical Preparations;pharmacologic;Physiology;Population;Post-Traumatic Stress Disorders;Pre-Clinical Model;Process;Property;psychologic;psychostimulant;Public Health;receptor;Recreational Drugs;Regulation;Reproducibility;Research;reward circuitry;Rewards;Risk;Scientist;screening;Series;social;Structure;Surveys;Synapses;Technology;Testing;Therapeutic;Time;Tissues;tool;Toxic effect;Transcend;Transgenic Mice;Treatment Efficacy;Trust;Viral;Work

PROJECT_TITLE: Brain-wide circuit mapping to delineate therapeutic strategies for amphetamine abuse


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Radiation Oncology;Rare Diseases

PHR: NARRATIVE (Project 2) Radiation is a cornerstone treatment for glioblastoma but tumors inevitably recur due to radiation resistance. We have found that non-malignant cells in the glioblastoma microenvironment mediate radiation resistance by stimulating purine metabolism in cancer cells. This research proposal will define how metabolites from non-malignant cells promote glioblastoma purine metabolism and how interrupting this regulation could improve outcomes for patients.

PI_NAMEs: WAHL, DANIEL R (contact)

PROJECT_TERMS: Astrocytes;Biological Assay;Brain;Brain Neoplasms;cancer cell;Cells;chemoradiation;chemotherapy;Clinical Trials;Consumption;Data;Defect;DNA Repair;Dose;Environment;Enzymes;Excision;Exhibits;FDA approved;Genomic approach;Genotype;Glioblastoma;Glioma;Glutamine;Goals;Guanosine Triphosphate;Human;Immunohistochemistry;Implant;improved;improved outcome;in vivo;inhibitor;Interruption;Invaded;Locally Advanced Malignant Neoplasm;Malignant Neoplasms;Measurement;Measures;Mediating;Mediator;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;Methodology;Modeling;Molecular Target;Mus;mycophenolate mofetil;Neurons;Neurosphere;Neurotransmitters;Newly Diagnosed;Non-Malignant;Nonhomologous DNA End Joining;Operative Surgical Procedures;Organoids;patient derived xenograft model;Patient-Focused Outcomes;Patients;pharmacologic;Phase;Phase I Clinical Trials;Phase Ib Clinical Trial;Physiological;Primary Brain Neoplasms;Proliferating;Purine Antagonist;purine metabolism;Purines;Radiation;Radiation Dose Unit;Radiation Induced DNA Damage;radiation resistance;Radiation Tolerance;radioresistant;Radiosensitization;randomized trial;Recommendation;Recurrence;Regulation;repaired;Research;Research Proposals;Resected;Resistance;Role;Serine;Signal Transduction;single-cell RNA sequencing;stable isotope;standard of care;temozolomide;Testing;Therapeutic;Therapeutic Index;tumor;Tumor Tissue;Xenograft Model

PROJECT_TITLE: Project 2: Overcoming GBM RT-resistance


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Heart Disease

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE The primary goal of this study is to assess real-world effectiveness and implementation of an evidence-based multi-component strategy to achieve equity in the allocation rate of advanced heart failure therapies, heart transplants and ventricular assist devices. This study proposes to implement evidence-based strategies that reduce bias, replace subjective evaluations with objective criteria, and improve group dynamics in a randomized cluster trial. Our rigorously designed trial will inform national guidelines for advanced heart failure therapy allocation, and data are likely to be generalizable to other organ replacement treatments and advanced chronic disease decision-making processes.

PI_NAMEs: BREATHETT, KHADIJAH  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Address;Adherence;Adoption;Affect;Attitude;behavior change;behavior change wheel;Chronic Disease;Clinical Trials;cluster randomized design;Cluster randomized trial;Color;Complex;Data;Decision Making;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation trial;Electronics;Eligibility Determination;Equity;Ethnic Origin;Evaluation;evidence base;Gender;Goals;Guidelines;health equity;Heart;Heart failure;Heart Transplantation;Hospitalization;implantation;implementation evaluation;implementation outcomes;implementation science;implementation strategy;implicit bias;improved;Individual;Infrastructure;Institute of Medicine (U.S.);Knowledge;Learning;Life;Maintenance;Measures;medication compliance;meetings;Methods;Modeling;Motivation;multidisciplinary;Organ;Outcome;Patients;people of color;Persons;Phenotype;Population;Process;programs;Protocols documentation;Race;racial minority;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Resources;self reported behavior;Site;Social support;Standardization;Surveys;Testing;theories;Therapy trial;Training;Treatment Failure;trial design;Variant;ventricular assist device;Voting;Woman;women patients

PROJECT_TITLE: Seeking Objectivity in Allocation of Advanced Heart Failure (SOCIAL HF) Therapies Trial

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ORG_DEPT: PATHOLOGY

PHR: Project Narrative This project explores the intersection of two fundamental areas, namely the cellular (mal)adaptation to primary mitochondrial dysfunction and the biology of the mitochondrial Ca2 + uniporter complex (MCUC). Here we propose to test the hypothesis that the MCUC serves a protective role during early stage mitochondrial myopathy, by augmenting energy production and mitigating stress signaling that could lead to muscle atrophy, and a detrimental role during later phases of mitochondrial dysfunction in skeletal muscle. These studies are expected to uncover novel regulation of the (mal)adaptive response to mitochondrial dysfunction and of muscle mass in myopathy, representing new roles for the MCUC in a post- mitotic cell environment.

PI_NAMEs: SEIFERT, ERIN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acute;Address;Aerobic Exercise;Affect;Area;Bioenergetics;biological adaptation to stress;Biology;Calcium;calcium uniporter;Cardiac;Cell Death;Cell model;Cell Survival;Cells;Complex;Crista ampullaris;Cytoplasm;Data;Disease Progression;DNA;Endoplasmic Reticulum;endoplasmic reticulum stress;Environment;Evaluation;exercise capacity;exercise intolerance;frataxin;Human;imaging approach;imaging genetics;Imaging Techniques;improved;in vivo;Incidence;insight;Left;Link;literature survey;Measurement;Metabolism;Methods;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;Mitochondrial Myopathies;mitochondrial permeability transition pore;Mitochondrial Swelling;Modeling;mouse model;Mus;Muscle Cells;Muscle Fibers;muscle form;Muscle Mitochondria;Muscular Atrophy;Muscular Dystrophies;Mutation;Myoblasts;Myopathy;novel;Nuclear;Organ;Oxidation-Reduction;Oxidative Phosphorylation;Pathology;Pattern;Pharmaceutical Preparations;pharmacologic;Phase;Phosphate Carriers;postmitotic;Process;Production;protein expression;Proteins;proteostasis;Publishing;Regulation;Reporting;response;Role;sensor;Side;Signal Pathway;Signal Transduction;skeletal;Skeletal Muscle;small molecule;Stress;Testing;Toxin;Translations;uptake

PROJECT_TITLE: Relevance of mitochondrial calcium uniporter for mitochondrial myopathy

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: WILLIAMS, LEANNE  (contact)

PROJECT_TERMS: Accounting;Acute;Address;Affective;Air;animal data;Award;Back;Behavior;behavior observation;behavior test;Behavioral;Behavioral Mechanisms;Biochemical;Biological Markers;Blinking;Brain;brain behavior;Cognitive;cognitive function;Complex;Corpus striatum structure;Cues;Data;design;Dissociation;Dose;drug action;drug of abuse;Drug usage;ecstasy;Emotional;Empathy;executive function;experience;Eye;Foundations;Funding;Goals;Hour;Human;human data;human subject;Hydrocortisone;Individual;individual variation;innovation;interest;Intervention;Intoxication;Ketamine;Knowledge;Maps;Measures;Memory;Modeling;mouse model;Nature;negative affect;neural;neural circuit;neurobiological mechanism;neuroimaging;Nociception;Outcome;Patient Self-Report;perceived stress;Persons;Pharmaceutical Preparations;Phase;Placebo Control;Placebos;Positioning Attribute;Prevention strategy;Procedures;Reaction Time;Resolution;response;Rest;reward circuitry;Rewards;Rodent Model;Sampling;Sensory;social;Stimulant;Stimulus;Stress;Testing;Thalamic structure;Time;Translating;Translations;Work

PROJECT_TITLE: Brain circuit, behavior and experience signatures of human drug-altered states


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Orphan Drug;Radiation Oncology;Rare Diseases;Women's Health Research

PHR: NARRATIVE (Project 3) Locoregional control for women with locally advanced ER-positive (ER+) and triple-negative (TN) breast cancer (BC) remains a significant clinical challenge despite standard radiation therapy, which could be addressed by radiosensitization. This study will determine the mechanism of CDK 4/6 inhibitor-mediated radiosensitization, the efficacy of this combination in vivo in ER+ and TNBC models and will allow for a first-in-human phase I trial establishing the safety and efficacy of such an approach in women with locally advanced breast cancer.

PI_NAMEs: SPEERS, COREY W. (contact)

PROJECT_TERMS: Address;Adjuvant;advanced breast cancer;Affect;African American Women;Aftercare;Animals;Apoptosis;Area;Biological Assay;Biological Models;Biopsy;Breast Cancer cell line;Breast Cancer Model;Breast Epithelial Cells;cancer radiation therapy;CDK4 gene;Cell Line;CHEK1 gene;Clinical;Clinical Research;Clinical Trials;clinically relevant;Combined Modality Therapy;Credentialing;Critical Pathways;Data;Dependence;Diagnosis;Disease;DNA Damage;DNA Repair;DNA Repair Gene;Dose;ds-DNA;effective therapy;efficacy evaluation;efficacy trial;Estrogen receptor positive;first-in-human;Future;Growth;high risk;High Risk Woman;Histopathologic Grade;homologous recombination;Immunohistochemistry;implantation;improved;In Vitro;in vivo;in vivo Model;inhibitor;interest;Ionizing radiation;irradiation;Kinetics;Lasers;Lead;liquid biopsy;Locally Advanced Malignant Neoplasm;Lymph Node Involvement;lymph nodes;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammospheres;Measures;Mediating;Microscopic;Modeling;Molecular Target;mortality risk;Mus;mutant;Neoadjuvant Therapy;Nonhomologous DNA End Joining;Nonmetastatic;novel;patient derived xenograft model;Patient Selection;Patients;Pharmacodynamics;Phase;Phase I Clinical Trials;phase I trial;Population;Positive Lymph Node;protein expression;Quality of life;Radiation;radiation resistance;Radiation therapy;Radiation Tolerance;Radiation-Sensitizing Agents;Radiosensitization;recombinational repair;Recommendation;Recurrence;Recurrent disease;Reporter;Reporting;research clinical testing;Residual state;response;Retinoblastoma;Risk;Safety;standard of care;Symptoms;Techniques;Testing;Therapeutic;Treatment outcome;Treatment Protocols;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor xenograft;Western Blotting;Woman;women's diagnosis;women's treatment;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Project 3: Credentialing CDK 4/6 inhibitors used with radiation as an effective treatment strategy in locally advanced ER+ and TNBC


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: KINGSVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY-KINGSVILLE

PHR: Project Narrative The fate and function of cells, tissues, organs, and organisms are determined by the expression of specific set of genes in the genome. This project aims to pinpoint the mechanism controlling DNA demethylation which is the principal means of gene expression regulation and genome stability. The outcome of this project will shed light on DNA methylation-specific regulation of gene expression and DNA damage repair in human cells and may have broader impacts on a variety of human diseases including cancer and neurodegenerative diseases.

PI_NAMEs: KIM, HAEYOUNG  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: age related;anti-cancer therapeutic;Attention;Base Excision Repairs;Biological Assay;Biomedical Research;Blood;Brain;Cell Line;Cell Physiology;cell type;Cells;conditional knockout;CpG dinucleotide;CRISPR/Cas technology;Cytosine;demethylation;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Methylation;DNA Modification Methylases;DNA Repair;drug discovery;Enzymes;epigenetic marker;Epigenetic Process;epigenetic regulation;Family;Functional disorder;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Genome;Genome Stability;Glioblastoma;Goals;high throughput screening;Human;human disease;human DNA;human induced pluripotent stem cells;Induced Neurons;Induced pluripotent stem cell derived human neuron;knock-down;Knowledge;Light;Link;Lymphoma;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Metabolism;Methylation;Mitotic;Modeling;mortality;Neurodegenerative Disorders;Neurons;novel;novel marker;novel therapeutics;Nuclear;Nucleotides;Organ;Organism;Outcome;oxidation;Pathway interactions;postmitotic;Process;Production;Proteins;repaired;Resistance;response;Role;Site;Survival Rate;System;Techniques;Testing;Thymine DNA Glycosylase;Time;Tissue-Specific Gene Expression;Tissues;translocase;tumor progression

PROJECT_TITLE: Control mechanisms of 5-hydroxymethylcytosine metabolism in human cells


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Mental Health;Mental Illness;Pain Research;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Rates of suicide continue to increase37 due to the lack of causal evidence necessary to develop effective interventions for suicidal behavior.38 This study will provide causal evidence for two modifiable mechanisms linking social pain and suicidal behavior: impaired decision-making and physiological arousal. This study will directly inform the assessment and prediction of suicidal behaviors and will aid in the development of novel interventions that target key mechanisms.

PI_NAMEs: BROWN, SARAH LOUISE (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Age;Arousal;Attention;Behavior;Behavioral;Biofeedback;Cause of Death;Chronic;Clinical;Cognition;Cognitive;Crossover Design;Decision Making;Development;Diagnostic;effective intervention;Exclusion;Exhibits;experience;experimental study;Feedback;Feeling suicidal;Fellowship;follow-up;Future;Goals;high risk;high risk population;Impairment;improved;innovation;Interruption;Intervention;Interview;Laboratories;Link;Longitudinal Studies;Measures;Mediating;Methodology;Methods;Modeling;modifiable risk;Modification;neglect;novel;Outcome;Pain;pain behavior;Pain Threshold;Participant;Patient Self-Report;Perception;Personality;Persons;Physiological;Predictive Value;preference;Process;Proxy;Psychophysiology;Randomized;recruit;reducing suicide;Research;respiratory;response;Rewards;Risk;Risk Factors;risk prediction;Role;Sampling;Sinus;skills;social;social engagement;social exclusion;social stress;Stress;suicidal behavior;suicidal risk;Suicide;suicide attempter;suicide model;Suicide prevention;suicide rate;System;Testing;theories;Time;Training;translational approach;virtual reality;virtual reality simulation;Withdrawal;Work;young adult

PROJECT_TITLE: Causal Mechanisms Underlying Social Pain and Suicidal Behaviors: Examining the Role of Altered Decision-making and Psychophysiological Reactivity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Radiation Oncology

PI_NAMEs: SCHIPPER, MATTHEW  (contact)

PROJECT_TERMS: Algorithms;analysis pipeline;Bioinformatics;bioinformatics infrastructure;Biometry;Cancer Center;Clinical Data;Clinical Trials Design;Collaborations;Computational Biology;Conduct Clinical Trials;Consult;Data;Data Analyses;data exchange;data integrity;data management;Data Set;data sharing;Development;Ensure;experience;experimental study;Faculty;flexibility;Human Resources;Information Management;Laboratories;Locally Advanced Malignant Neoplasm;member;Michigan;Modeling;Modernization;Molecular Target;pre-clinical;programs;Radiosensitization;Research;Research Design;Research Personnel;single-cell RNA sequencing;Standardization;Statistical Data Interpretation;Technology;Universities;Work

PROJECT_TITLE: Core A: Biostatistics and Computational Biology Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: DURHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DUKE UNIVERSITY

PHR: The emergence of multidrug resistant microbes is a serious threat to human health. Delineating the molecular mechanisms behind essential processes unique to microbes presents opportunities for rational design of specific therapeutics to combat this growing concern.

PI_NAMEs: SCHUMACHER, MARIA  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Anti-Bacterial Agents;anti-microbial drug;Antimicrobial Resistance;Bacteria;bacterial resistance;Biochemistry;Biological;Biological Process;Cessation of life;combat;Complex;Cryoelectron Microscopy;Cues;Development;DNA;DNA Repair Pathway;drug resistant microorganism;environmental change;Enzymes;Genetic Transcription;Glutamate-Ammonia Ligase;Goals;Gram-Positive Bacteria;Health;Human;in vivo;interest;Investigation;Life Cycle Stages;Link;Metabolic Pathway;Microbe;microbial;microbial disease;Mitochondria;Molecular;Multi-Drug Resistance;Nitrogen;novel;Nucleic Acids;Nutrient availability;Pathogenesis;Pharmaceutical Preparations;phosphoric diester hydrolase;Process;Proteins;Protozoa;rational design;RNA Editing;Second Messenger Systems;Signal Pathway;Signal Transduction;Source;Streptomyces;Structure;Therapeutic;therapeutic target

PROJECT_TITLE: Deciphering fundamental biological processes involving protein-nucleic acid interactions at the molecular level


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE The objective of the training program in Basic Medical Oncology at the University of Chicago is to provide an outstanding interdisciplinary research training environment for clinician postdoctoral fellows who have completed internal medicine residency training. Physicians completing our training program will enter the oncology work force as socially responsible citizens who are prepared to lead cancer-focused research teams in academia, government or industry.

PI_NAMEs: OLOPADE, OLUFUNMILAYO F. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TITLE: Basic Medical Research Training in Oncology


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Radiation Oncology

PI_NAMEs: SCHUETZE, SCOTT MICHAEL (contact)

PROJECT_TERMS: Adverse event;adverse event monitoring;Basic Science;Biometry;Cancer Center;cancer clinical trial;cancer type;career;Clinical Data;Clinical Protocols;Clinical Research;clinical trial implementation;Clinical Trials;Clinical Trials Support Unit;Collaborations;Collection;Communication;Complex;Computational Biology;Conduct Clinical Trials;Data;data management;data sharing;Development;Ensure;experience;Good Clinical Practice;Human;Image;Informed Consent;Infrastructure;Institution;Institutional Review Boards;Leadership;Locally Advanced Malignant Neoplasm;Maintenance;Medical Oncology;medical schools;Mentors;Michigan;Molecular Target;Monitor;mortality;Outcome;Participant;Pathology;Patient Recruitments;patient retention;Patients;Population Research;Principal Investigator;Process;programs;protocol development;Protocols documentation;Publications;quality assurance;Questionnaires;Radiation Oncology;Radiosensitization;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Review Committee;Safety;Services;skills;Thinness;tool;Translational Research;Translations;Universities

PROJECT_TITLE: Core B: Clinical Trials Core


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes

ORG_CITY: MONTREAL

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: MCGILL UNIVERSITY HEALTH CTR RES INST

ORG_STATE: PQ

ORG_ZIPCODE: H3H 2R9

PHR: Project narrative Our novel approach for improving type 1 diabetes treatment involves using an automated insulin delivery (AID) system with an ultra-rapid insulin analogue, Lyumjev, and adjunctive glucagon-like peptide-1 receptor agonist (GLP1-RA), Semaglutide, to simplify mealtime diabetes management by alleviating the need of carbohydrate counting. The data from our study may demonstrate that an AID system with meal announcement and weekly injections of Semaglutide can achieve clinically non-inferior daytime glycemic control to a conventional insulin-alone AID system that requires carbohydrate counting. We hope the results of our clinical trial will prompt new studies with GLP1-RA to further explore the benefits of this drug in type 1 population, as well as encourage more studies that aim to reduce the burden of mealtime management in people with type 1 diabetes. Page 1 of 1

PI_NAMEs: TSOUKAS, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Adherence;Adult;Agonist;analog;Area Under Curve;arm;Beta Cell;Blood Glucose;blood glucose regulation;Body Weight decreased;Bolus Infusion;Brain;C-Peptide;Carbohydrates;Cell Physiology;Clinical;Clinical Trials;comparison control;Consumption;Cross-Over Trials;Data;design;Devices;diabetes distress;diabetes management;diabetes self-management;Distress;Dose;Double-Blind Method;Emotional;Fasting;Formulation;Future;Gastric Emptying;GLP-I receptor;Glucagon;glucagon-like peptide 1;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;gut endocrine cell;Hormones;Hypoglycemia;improved;increased appetite;Individual;Ingestion;Injections;Insulin;insulin secretion;Insulin, Lispro, Human;Insulin-Dependent Diabetes Mellitus;interest;Intervention;Label;Lead;Length;Measures;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Placebo Control;Placebos;Population;primary outcome;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;response;Satiation;Surveys;System;Testing;Time;Titrations;trial comparing

PROJECT_TITLE: Alleviating carbohydrate counting in adults with type 1 diabetes with weekly Semaglutide injections added to an automated insulin delivery with Lyumjev

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

PHR: Narrative: Mycobacterium tuberculosis, the causative agent of tuberculosis disease, remains a global public health challenge, and development of new interventions and identification of drug resistance are among the objectives of the World Health Organization End TB Strategy. Leveraging on the success of the TM4 mycobacteriophage and the sensitivity of the nanoluciferase reporter enzyme, the proposed work will offer a rapid, cost-effect phenotypic reference method drug susceptibility testing of M. tuberculosis.

PI_NAMEs: JACOBS, WILLIAM ROBERT;O'DONNELL, MAX  (contact);PERUMAL, RUBESHAN

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Antibiotic susceptibility;Antimycobacterial Agents;bactericide;Bacteriophages;BCL2/Adenovirus E1B 19kd Interacting Protein 3-Like;Biological;Biological Assay;Bioluminescence;Caring;Clinical;clinical phenotype;clinically relevant;Cohort Studies;Collaborations;Colony-Forming Units Assay;community transmission;Complement;Complex;cost;Data;Detection;detection limit;detection platform;Development;Diagnosis;Diagnostic;diagnostic assay;Disease;DNA cassette;drug repurposing;Drug resistance;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;drug testing;Drug usage;drug-sensitive;Early identification;Energy Transfer;Ensure;Enzymes;experience;experimental study;Fluorescence;fluorophore;Gene Modified;Generations;Genetic;genome sequencing;Genotype;Genus Mycobacterium;global health;Growth;implementation science;improved;Income;Infection;instrumentation;Intermediate resistance;Intervention;Laboratories;Linezolid;luminescence;Measures;Mediating;Methods;Minimum Inhibitory Concentration measurement;Monitor;Morbidity - disease rate;mortality;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;Mycobacteriophages;Mycobacterium tuberculosis;nanoluciferase;next generation;novel;novel therapeutics;Oral;Outcome;Patients;Performance;Persons;phage vector;Pharmaceutical Preparations;Phenotype;phenotypic data;Predisposition;preservation;prevent;Process;programs;Prospective, cohort study;Public Health;Publishing;Reader;Regimen;Reporter;Research;Resistance;resistant strain;Reverse Transcriptase Polymerase Chain Reaction;Rifampicin resistance;Rifampin;Sampling;Scientist;side effect;Signal Transduction;South African;Sputum;success;System;Techniques;Testing;Therapeutic;Time;treatment duration;Treatment outcome;Treatment Protocols;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;tuberculosis drugs;tuberculosis treatment;Validation;Virulent;Virus;whole genome;Work;World Health Organization

PROJECT_TITLE: Nanoluciferase reporter phage for rapid phenotypic characterization of resistance to next-generation antimycobacterial agents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DDR-C(01)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Radiation Oncology

PI_NAMEs: REHEMTULLA, ALNAWAZ  (contact)

PROJECT_TERMS: Address;Animal Model;Animals;Biological Models;Bioluminescence;Biometry;Cancer Center;Cancer Model;Cancer Therapy Evaluation Program;Cell model;Cells;Clinical;clinical practice;Clinical Trials;Combined Modality Therapy;Computational Biology;Computer Analysis;Consensus;Cultured Cells;design;Development;Developmental Therapeutics Program;Discipline;Disease;DNA Repair;Dose;Drug Kinetics;Ensure;Evaluation;experience;Goals;Human;Image;image guided;image guided radiation therapy;improved;In Vitro;in vivo;insight;instrument;instrumentation;irradiation;Knowledge;Lasers;Lead;Locally Advanced Malignant Neoplasm;Malignant Neoplasms;Medical;Michigan;Modeling;molecular imaging;Molecular Target;Monitor;mouse model;Pathology;Patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Physics;pre-clinical;Pre-Clinical Model;preclinical imaging;preclinical study;Procedures;professor;programs;Radiation;radiation delivery;Radiation Oncology;Radiation Physics;Radiation therapy;Radiation-Sensitizing Agents;Radiosensitization;Research;Research Activity;Research Personnel;Research Project Grants;Resource Sharing;Resources;Schedule;Services;subcutaneous;success;targeted agent;Technology;Testing;Therapeutic;Therapeutic Agents;Therapeutic Equivalency;therapeutic evaluation;therapy development;Translating;Translations;Treatment Efficacy;treatment planning;treatment response;tumor;Tumor Burden;Universities;Work

PROJECT_TITLE: Core C: Radiosensitization Core


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Black Americans have worse hospital outcomes and the hospitals that serve a high proportion of Black Americans are more likely be lower quality; however, little is known about what modifiable aspects of these Black-serving hospitals underlie their poorer quality. In this proposal, we bring a new perspective to the long- standing challenge of achieving health equity in hospital care and patient outcomes, by evaluating whether the differences in hospital nurse resources explain poorer outcomes among those cared for in Black-serving hospitals.

PI_NAMEs: LASATER, KAREN BLANCHETTE (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Academy;Accounting;Address;Admission activity;Advanced Practice Nurse;Advocate;Affect;Age;Attention;Beds;Black American;black patient;Black Populations;Black race;care outcomes;Caring;Characteristics;Clinical;Clinical Nursing;Communities;comorbidity;Comprehensive Health Care;COVID-19 mortality;COVID-19 pandemic;Data;Death Rate;Decision Making;Desegregation;Diagnosis;Discipline of Nursing;Disparity;disparity reduction;Educational process of instructing;Family;Floor;Fortification;Fostering;Goals;health determinants;health equity;Healthcare;Healthcare Systems;hospital care;Hospital Nursing;hospital readmission;Hospitalists;Hospitalization;Hospitals;improved;improved outcome;indexing;Individual;Inequity;Infrastructure;Intervention;Investments;Legal;Length of Stay;Linear Regressions;Link;Logistic Regressions;Measures;Medical;Medicare;Medicine;minority patient;Modeling;mortality;New York City;novel strategies;Nurse's Role;Nurses;Nursing Staff;Observational Study;older adult;Operative Surgical Procedures;Outcome;outcome disparities;Patient Care;Patient-Focused Outcomes;Patients;Physicians;Policies;poor health outcome;professional atmosphere;Quality of Care;racial disparity;racial health disparity;racial minority;Racial Segregation;racism;Records;recruit;Registered nurse;Reporting;Research;Resources;response;Severity of illness;sex;skills;social;social health determinants;Surveys;Teaching Hospitals;Technology;Translational Research;Urban Hospitals

PROJECT_TITLE: Differences in Hospital Nursing Resources among Black-Serving Hospitals as a Driver of Patient Outcomes Disparities


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Young children’s social-emotional-behavioral health and school success are inextricably linked, and both have been adversely affected by racial and economic inequities exacerbated by the COVID-19 pandemic. This study will 1) test the effects of a universal group-based parenting intervention in prekindergarten on a range of parent, child, and school outcomes associated with children’s wellbeing and later academic success and 2) evaluate its cost, acceptability, implementation, and sustainability when offered in different formats (virtual vs in-person) in urban and rural public schools serving low-income students. This study seeks to improve children’s social-emotional-behavioral wellbeing, kindergarten readiness skills, and school outcomes by building on parents’ strengths and promoting engagement in their children’s education during the early years.

PI_NAMEs: BETTENCOURT, AMIE F;GROSS, DEBORAH A. (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Adoption;Affect;Baltimore;Behavioral;behavioral health;Chicago;Child;Child Rearing;Child Support;Child Welfare;Chronic;Chronic disability;Cities;cluster randomized design;Communities;Competence;cost;cost effectiveness;COVID-19;COVID-19 pandemic;Data;design;Development;early childhood;Economics;Education;Effectiveness;effectiveness/implementation trial;Emotional;Emotions;evidence base;Exhibits;experience;externalizing behavior;Family;Foundations;Growth;Growth and Development function;Human Resources;Hybrids;improved;Inequity;informant;Instruction;Intervention;kindergarten;Learning;Learning Skill;Link;Low income;Maryland;Mediating;Mental Health;Methods;National Institute of Child Health and Human Development;Nursery Schools;Outcome;pandemic disease;parenting intervention;Parents;Personal Satisfaction;Persons;physical conditioning;post intervention;Problem behavior;Problem Solving;Program Effectiveness;Quality of life;Race;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Research Support;Resources;Role;Rural;rural poverty;school district;Schools;skills;social;social emotional learning;social interventions;Students;success;teacher;Testing;therapy design;uptake;urban poverty;virtual;virtual group

PROJECT_TITLE: Strengthening Parenting, Young Children's Social-Behavioral Competence, and Kindergarten Readiness in Schools Serving Low-Income Communities

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Hypertension is the biggest risk factor for cardiovascular disease. The long-term goal and clinical significance of this F30 grant application is to determine how surgically taking away the nerves from the kidneys to the brain can be used to lower blood pressure in patients with hypertension. The results from these studies will serve as an important platform for therapeutic initiatives focused on utilizing the nervous system to treat cardiovascular diseases.

PI_NAMEs: DE LA CRUZ-LYNCH, ARTHUR TRENTON (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Ablation;Acetates;Address;afferent nerve;Aftercare;Anatomy;Anti-Hypertensive Agents;Applications Grants;Biological Markers;Blood Pressure;blood pressure reduction;blood pressure regulation;Blood Volume;Brain;Capsaicin;Cardiac Output;Cardiovascular Diseases;cardiovascular risk factor;Catheters;Cells;chemokine;Chronic;Clinical;Clinical Trials;clinically relevant;clinically significant;comparative efficacy;CXCL10 gene;CXCR3 gene;cytokine;Deoxycorticosterone;Disease;Doctor of Philosophy;Drug resistance;Echocardiography;Efferent Neurons;Ensure;Enzyme-Linked Immunosorbent Assay;Ethanol;experimental study;Foundations;Functional disorder;Future;Goals;Harvest;heart function;hemodynamics;Hemorrhagic Shock;high salt diet;Human;Hypertension;hypertension treatment;IL17 gene;Immune;Immunohistochemistry;Implant;Inflammation;Inflammatory;insight;Interleukin-1 alpha;Intervention;Kidney;Laboratories;Life Style Modification;Liver;Measurement;Measures;Methods;minimally invasive;Modeling;Monitor;Nerve;Nervous System;neuroregulation;neurotransmission;novel;novel therapeutics;Operative Surgical Procedures;Organ;Output;Patients;Peripheral;Pharmaceutical Preparations;Physicians;Physiological;Plasma;Play;Pre-Clinical Model;preservation;pressure;Property;Rattus;renal artery;Reporting;Research;Resistance;Resistant Hypertension;response;Rodent;Rodent Model;Role;Saline;Sampling;Scientist;Sensory;Septic Shock;Sheep;sheep model;skills;Spleen;success;Technology;telemetering;Testing;Therapeutic;TNF gene;Translating;Translational Research;transmission process;Treatment Efficacy;Tunica Adventitia;urinary;Urine

PROJECT_TITLE: Evaluating the Mechanisms of Afferent Renal Nerve Ablation as a Treatment for Hypertension


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Radiation Oncology;Rare Diseases

PI_NAMEs: GIORDANO, THOMAS JAMES (contact)

PROJECT_TERMS: Animal Model;Archives;Brain;brain tissue;Breast;breast pathology;Cancer Center;Cancer Center Support Grant;career;Clinical;Clinical Trials;Confidentiality of Patient Information;Data;Data Analyses;Development;Diagnosis;Diagnostic;Ensure;experience;Future;Gene Expression;Genetic Markers;Genomics;Glioma;Goals;Histologic;Human Resources;human tissue;Immunohistochemistry;Immunologic Monitoring;Infrastructure;Institutional Review Boards;Investigation;Lead;Locally Advanced Malignant Neoplasm;Malignant neoplasm of pancreas;Mammary Gland Parenchyma;Michigan;molecular pathology;Molecular Target;Operative Surgical Procedures;Pancreas;Pathologist;Pathology;Patient Care;Patients;pre-clinical;Process;prospective;Protocols documentation;Radiosensitization;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Services;Specimen;support network;Surgical Pathology;tissue processing;Tissue Procurements;tissue resource;Tissue Sample;Tissues;translational goal;Translational Research;Universities;University resources;validation studies;Work

PROJECT_TITLE: Translational Pathology Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Palliative Care;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: MILWAUKEE

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative This project aims to address two important Healthy People 2030 goals: 1) Improve the health, function, and quality of life of older adults, and 2) Prevent unintentional injuries and violence, and reduce their consequences. Trainees will collaborate with experienced research faculty and research teams on injury-related projects relevant to aging, including falls prevention, cognitive function, vision loss, depression/ suicide, toxicology and polypharmacy, patient safety, and quality of life after trauma. It is critical to examine the risks and mechanisms of injury and response to trauma and trauma care from a life-stages perspective, and to look at the unique needs of the elderly in injury prevention, acute treatment and rehabilitation.

PI_NAMEs: MEURER, LINDA N. (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Address;aged;Aging;Attention;Basic Science;care systems;career;career development;Chronic Disease;Clinical;Clinical Sciences;cognitive function;Collaborations;Communities;Community Medicine;Decision Making;Disease Management;educational atmosphere;Elderly;Emergency Medicine;Ethics;experience;Exposure to;Faculty;faculty mentor;Fall prevention;falls;Family Practice;frontier;Funding;Geriatrics;Goals;Health;Home;improved;Infrastructure;Injury;injury prevention;Institution;interest;Knowledge;Laboratories;Life;life span;medical schools;Medical Students;Medicine;Mental Depression;Mentorship;neuromuscular function;Older Population;Operative Surgical Procedures;Outcome;Palliative Medicine;Pathway interactions;patient safety;Policies;population health;Population Sciences;posters;Prevention Research;programs;Quality of life;Research;research faculty;Research Training;Risk;Risk Factors;Safety;skills;Social Sciences;Special needs;student training;Students;Suicide;summer research;Time;Toxicology;Training;Training Programs;translational pipeline;Translational Research;Trauma;trauma care;Wisconsin;Work

PROJECT_TITLE: Medical Student Training in Aging and Injury Research


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Estrogen;Neurosciences;Pediatric;Substance Misuse;Underage Drinking;Women's Health Research

ORG_CITY: GREENSBORO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NORTH CAROLINA AGRI & TECH ST UNIV

PHR: Project Narrative Alcohol use disorders are a major public health concern afflicting approximately 17 million Americans, often beginning with binge drinking during adolescence. The proposed studies will determine how adolescent ethanol exposure and ethanol re-exposure in adulthood influences (1) sex-specific neuronal activation of steroid receptor containing neurons within mesocorticolimbic structures and (2) circulating steroid and metabolomic profiles. Completion of this work will elucidate short- and long-term impacts of adolescent ethanol exposure on critical brain structures and their circuits that underlie long-lasting changes in alcohol drinking in males and females.

PI_NAMEs: MALDONADO-DEVINCCI, ANTOINETTE MICHELLE (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;adolescent alcohol exposure;adolescent binge drinking;adolescent brain development;adolescent substance use;Adult;Adult women;Affect;Alcohol consumption;alcohol exposure;alcohol measurement;alcohol research;alcohol use disorder;Alcohols;Allopregnanolone;American;Amygdaloid structure;Androgens;Behavior;Behavioral;Binding;binge drinking;Brain;brain health;Brain region;cell type;Chronic;Coupled;Dependence;Development;drinking;drinking behavior;Enzyme-Linked Immunosorbent Assay;Estradiol;Estrogen Receptor 2;Estrogens;Ethanol;Female;Female Adolescents;FOS gene;Future;Genetic;Genetic Markers;Goals;Gonadal Steroid Hormones;GPER gene;GTP-Binding Proteins;Hippocampus;Hormonal;Hormones;Human;Immediate-Early Genes;Immunofluorescence Immunologic;insight;Liver;male;Male Adolescents;Maps;Medial;Mediating;Metabolic;metabolomics;Mus;neurobiological mechanism;Neurobiology;neurodevelopment;neuromechanism;Neurons;Neurosecretory Systems;neurosteroids;Nuclear;Nuclear Magnetic Resonance;Nucleus Accumbens;paraventricular nucleus;Pattern;Play;pre-clinical;Predisposition;Prefrontal Cortex;Progesterone;Proteins;Puberty;Public Health;receptor;receptor function;Regulation;Research;Risk;Rodent;Role;Sampling;Serum;sex;Sex Differences;small hairpin RNA;Steroid Receptors;Steroids;Structure;Structure of terminal stria nuclei of preoptic region;Testosterone;Time;underage drinking;Withdrawal;Work

PROJECT_TITLE: Adolescent alcohol exposure: impact on neuronal activation, steroids, and metabolomic profiles