FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Biotechnology;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: COSMIIC Supplement Request - MPS Module Development Project Narrative The goal of this supplement is to develop a multi-polar stimulation module that can be incorporated into the COSMIIC Platform System.

PI_NAMEs: CHESTEK, CYNTHIA ANNE;KILGORE, KEVIN L. (contact);SMITH, BRIAN

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: Charge;design;Development;electric impedance;Electrodes;Goals;Intramuscular;Lead;Monitor;Muscle;Nerve;Neurostimulation procedures of spinal cord tissue;Output;Physiologic pulse;prototype;Research;Resolution;Source;Stimulus;System;Testing;Vagus nerve structure

PROJECT_TITLE: Multi-polar stimulation module


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Psychosis;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health

ORG_CITY: BLOOMINGTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The proposed research will determine factors influencing racial group differences in the phenotypic expression of paranoia in Black and White Americans in the general population. These findings will fill a critical knowledge gap by (1) identifying the group- and individual-level risk and resilience factors that may influence the heightened endorsement of paranoia observed in Black Americans and (2) determining the potentially causal role of racial discrimination on heightened paranoia endorsements observed among Black Americans. The project holds significant clinical and health relevance, offering crucial insights for culturally sensitive and accurate measurement of the psychosis spectrum in diverse ethnic and racial populations.

PI_NAMEs: WOLNY, J PAIGE (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Address;Adult;Assessment tool;Audiotape;Automobile Driving;Belief;Black American;Black race;Buffers;career;caucasian American;Clinical;clinical practice;clinically significant;Communities;comparison control;Cultural Sensitivity;Dedications;Diagnosis;Diagnostic;Dimensions;Discrimination;ethnic diversity;Ethnic Population;ethnoracial;experience;Exposure to;General Population;Goals;Health;Health Disparities Research;health disparity;Impairment;Individual;insight;Investigation;Knowledge;Light;Link;marginalized population;Measurement;Mediating;Mediator;Mental Health;Methods;Minority Groups;Nature;Outcome;Paranoia;Participant;Pathway interactions;Patient Self-Report;perceived discrimination;Personal Satisfaction;Phenotype;Play;Population;Population Heterogeneity;Procedures;protective factors;psychologic;Psychoses;psychosis risk;Psychotic Disorders;Quality of life;Race;racial discrimination;racial disparity;racial identity;racial population;Randomized;recruit;Research;resilience factor;Respondent;Risk;Risk Factors;Role;Sampling;Schizophrenia;Science;Severities;social;social culture;Social Functioning;social health determinants;Social Psychology;sociocultural determinant;stem;Structural Racism;Survey Methodology;Symptoms;Testing;theories;Training;trait;visual imagery

PROJECT_TITLE: Racial Disparities in the Expression of Paranoia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: Los Angeles

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Restriction of transcription factor (TF) binding by heterochromatin is essential for spatiotemporal control of gene expression and proper embryonic development. Despite developmental transitions from gene repression to activation being often initiated by pioneer factors which overcome the heterochromatin barrier, it remains poorly understood whether distinct types of heterochromatin differentially regulate DNA accessibility and TF binding. Here, I will directly compare how G9A/GLP and SETDB1, responsible for histone H3 Lysine 9 di and trimethylation, respectively, restrict TF and pioneer factor binding to the same gene regulatory sequences.

PI_NAMEs: LOWE, MATTHEW GREGORY (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Adult;Affect;ATAC-seq;Belief;Binding;C-terminal;Cell Differentiation process;Cell Lineage;Cells;Child;Chimeric Proteins;ChIP-seq;Chromatin;Chromatin Structure;Chromosome 7;Complex;Data;de novo mutation;derepression;Development;developmental disease;Developmental Gene;directed differentiation;Disease;DNA;Embryo;Embryonic Development;embryonic stem cell;Enhancers;exome sequencing;Feedback;Flow Cytometry;G9a histone methyltransferase;Gene Expression;gene repression;Genes;Genetic Predisposition to Disease;genome sequencing;Germ Layers;Health;Heterochromatin;Histone H3;histone methyltransferase;Histones;Human;Impairment;Junk DNA;Link;Lysine;Maps;Mediating;Methods;Methylation;Molecular;Mouse Embryonic Stem Cells;nerve stem cell;Neurodevelopmental Disorder;neuropsychiatry;novel strategies;Nucleosomes;Pathology;Permeability;Positioning Attribute;Predisposition;prevent;Process;programs;promoter;Proteins;recombinase-mediated cassette exchange;recruit;Regulation;Regulatory Element;Reporter;Repression;Resistance;Resolution;Role;SETDB1 gene;single-cell RNA sequencing;spatiotemporal;Specific qualifier value;stem cell differentiation;Syndrome;Testing;Time;Tissue-Specific Gene Expression;Tissues;transcription factor;Transcription Repressor;tumorigenesis;United States;Work;Zinc Fingers

PROJECT_TITLE: Understanding How Distinct Heterochromatin States Control Pioneer Factor Binding

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative Development of an Intra-body wireless sensor link for COSMIIC NNP The aim of this supplement is to create a COSMIIC System module that can wireless connect with wireless sensors indwelling in the body, such as a bladder pressure sensor.

PROJECT_TERMS: Algorithms;Architecture;Area;Bladder;Cardiovascular system;Communication;Coupled;Data;data communication;design;Development;Devices;Diameter;Disease;Electronics;Encapsulated;Feedback;flexibility;Funding;Human;Implant;improved;In Vitro;in vitro testing;Intrabody;Length;Link;Measurement;Measures;Miniaturization;miniaturize;Monitor;Nerve;Organ;Physiological;pressure sensor;printed circuit board;Printing;Radio;remote sensor;Saline;sensor;Signal Transduction;Silicones;System;Time;transmission process;wireless;wireless communication;wireless electronic;wireless sensor;wireless transmission

PROJECT_TITLE: Development of an intra-body wireless sensor link for COSMIIC NNP


ADMINISTERING_IC: TW

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Disability Research;HIV/AIDS;Infectious Diseases;Osteoporosis;Rheumatoid Arthritis

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The burden of rheumatic and musculoskeletal diseases (RMDs) is significant in Sub-Saharan Africa due to changing demographic patterns against a backdrop of resource limitation. A diverse range of RMDs have been described among persons with human immunodeficiency virus (HIV) and can occur at any stage of the disease; unfortunately, most countries in the region have not yet developed the research capacity to address RMDs, particularly in the setting of HIV. To address this gap, the proposed project will establish a novel registry of patients with co-existing HIV and RMD, and two comparator groups of patients with HIV alone and RMD alone and build a collaborative research network to support innovative research in this area.

PI_NAMEs: HSIEH, EVELYN  (contact);KADDUMUKASA, MARK

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Affect;Africa;Africa South of the Sahara;antiretroviral therapy;Area;behavioral outcome;Biological;Biology;bone;Bone Density;bone loss;bone metabolism;bone turnover;burden of illness;Chronic Disease;Clinic;Clinical;Clinical Research;Collaborations;college;comorbidity;comparison group;Consent;cost;Country;Data;Data Reporting;disability;disability-adjusted life years;Disease;Disease Outcome;Disease remission;Dual-Energy X-Ray Absorptiometry;early onset;Enrollment;epidemic virus;epidemiologic data;Epidemiology;epidemiology study;experience;Feasibility Studies;Fostering;Foundations;Fracture;Future;General Population;Health;Health Sciences;Healthcare Systems;Highly Active Antiretroviral Therapy;HIV;HIV Infections;Hospitals;immune reconstitution;Improve Access;Individual;Inflammatory Arthritis;Infrastructure;innovation;Institution;Joints;Life;Life Expectancy;Longitudinal Studies;low and middle-income countries;Measurement;medical schools;Morbidity - disease rate;mortality;Muscle;Musculoskeletal Diseases;novel;Organ;Osteoporosis;Outcome;Pain;Patient Care;patient registry;patient subsets;Patients;Pattern;Persons;Pilot Projects;Population;Prospective Studies;Public Health;Quality of life;Recording of previous events;Registries;Reporting;Research;Research Training;Resources;response;Rheumatism;Rheumatoid Arthritis;Rheumatology;Risk;Risk Factors;Serology;skeletal;Social Behavior;Training;Uganda;Universities;World Health Organization;Writing

PROJECT_TITLE: Building a Collaborative Research and Training Platform for HIV and Rheumatic and Musculoskeletal Diseases in Uganda

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Skin Cancer

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative The 7th Annual Workshop on Confocal Microscopy (CM) for Cutaneous Diagnostics aims to promote the use of CM and introduce the recent advances such as multimodal techniques, to improve care of patients with potentially malignant skin lesions. This workshop will teach the fundamentals of these techniques, their clinical application, and image acquisition skills. We will encourage participation and training of early-career clinicians and scientists from under-represented/minority groups by offering them free registration and observership via 20 scholarships.

PI_NAMEs: JAIN, MANU  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Accreditation;Address;Adoption;Anxiety;Basal cell carcinoma;Benign;Biopsy;cancer diagnosis;Carcinoma;career;case-based;Categories;Childhood;Cicatrix;Clinic;Clinical;clinical application;clinical diagnosis;Code;Confocal Microscopy;Consumption;cost;Cutaneous;Dermatology;Dermoscopy;Devices;Diagnosis;Diagnostic;diagnostic tool;diagnostic value;Disabled Persons;Educational process of instructing;Educational workshop;Elderly;Ensure;Face;Faculty;Familiarity;feature detection;Frozen Sections;Funding;Generations;Genitalia;Goals;Hair;healthcare burden;Hemorrhage;Histopathology;Hybrids;Image;imaging approach;Imaging Device;Imaging Techniques;Imiquimod;improved;in vivo;Individual;Infection;Inflammatory;Learning;lectures;Lesion;Malignant - descriptor;Malignant Neoplasms;Maps;Marketing;Medicine;melanocyte;Memorial Sloan-Kettering Cancer Center;microscopic imaging;Minority;Minority Groups;Mohs Surgery;multimodality;Nail plate;neoplastic;Neoplastic skin;non-invasive imaging;non-invasive monitor;non-invasive optical imaging;novel;Operative Surgical Procedures;Optical Coherence Tomography;Optics;outreach;Pathology;Patient Care;Patients;Persons;Population;Privatization;PUVA Photochemotherapy;Rapid diagnostics;reflectance confocal microscopy;Reporting;Residual Neoplasm;Residual state;Resolution;Resources;Scholarship;Scientist;skill acquisition;skills;Skin;Skin Cancer;skin lesion;Specificity;Standardization;success;Surgical margins;Techniques;Terminology;tertiary care;Time;tissue processing;Tissues;Training;Trauma;treatment response;Triage;tumor;Underrepresented Populations;virtual;Woman;wound healing

PROJECT_TITLE: 7th Annual Workshop on Confocal Microscopy for Cutaneous Diagnostics

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-E (M1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Endocrine disorders impact weight gain, metabolism, and mood. Adrenal Cushing’s syndrome occurs when defective protein kinase A (PKAc) signaling causes too much of the stress hormone cortisol to be released from adrenal glands. This proposal will change our understanding of adrenal Cushing’s syndrome in two ways: 1) we profile a newly discovered somatic mutation in PKAc that apparently occurs at high frequency in the patient population and 2) we introduce precision drug targeting strategies that direct PKAc inhibitors to subcellular organelles to suppress cortisol hypersecretion.

PI_NAMEs: SCOTT, JOHN D (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: A kinase anchoring protein;Adrenal Gland Diseases;Adrenal Glands;adrenal hyperplasia;Alleles;Amino Acids;Anabolism;analog;Animal Model;Animals;Architecture;Attenuated;Binding;Biochemical;Catalytic Domain;Cell Line;Cells;Chemicals;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;comorbidity;Cushing Syndrome;Cushingoid facies;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytoplasm;Data;Disease;Drug Targeting;Endocrine;Endocrine System Diseases;enzyme activity;Enzymes;Event;forging;Frequencies;Genetic;genetic regulatory protein;Holoenzymes;Hormones;Hydrocortisone;Hyperglycemia;Hypertension;innovation;Island;kidney dysfunction;Knock-out;Location;Mediating;men;Mental disorders;Metabolic;Metabolism;Molecular;Monitor;Moods;mutant;Mutation;nano;Non-Insulin-Dependent Diabetes Mellitus;novel;Organelles;parallel processing;Pathologic;patient population;Patients;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacology;Phosphoric Monoester Hydrolases;Phosphotransferases;Physiological;Physiological Processes;Physiology;precision drugs;Process;Protein Kinase;Protein Kinase A Inhibitor;protein protein interaction;Protein Region;Proteins;Proteomics;prototype;Regimen;response;Sampling;scaffold;screening;Signal Transduction;Signaling Protein;Site;Somatic Mutation;stem;steroidogenic acute regulatory protein;Stress;Symptoms;Syndrome;Testing;Tissues;Variant;Weight Gain;Women's prevalence

PROJECT_TITLE: Biased AKAP signaling mechanisms

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Limited healthcare resources in low resource settings in USA and developing countries necessitate practical solutions such as community-based rehabilitation and affordable robotics that enable caregivers and stroke survivors to interact and support rehabilitation in a community setting. Robot-based multiplayer serious games have the potential to increase patient motor learning and motivation in post-stroke rehabilitation, but research on haptic connection of players has been limited to healthy younger adults. This project will explore how age and stroke related motor and cognitive impairments inuence haptic communication, providing design insight for robot-based multiplayer rehabilitation games.

PI_NAMEs: WATERS, ERICA  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Acute;Address;Adult;Affect;Age;Automation;Caregivers;Case Study;Clinical;Cognitive;Communication;Communication impairment;Communities;community setting;cost;Crossover Design;Data;design;Developing Countries;disability;Doctor of Philosophy;Educational Background;Engineering;Esthesia;experience;Feedback;follow up assessment;force feedback;Friends;Goals;haptic feedback;haptics;Healthcare;Human;human data;human old age (65+);human-robot interaction;Impaired cognition;Impairment;improved;Individual;insight;Joints;kinematics;Knowledge;Laboratories;Lead;Learning;Literature;low and middle-income countries;Machine Learning;Measures;Mechanics;Mediating;Modeling;Motivation;Motor;motor impairment;motor learning;Noise;older adult;Outcome Measure;Participant;Patients;Pennsylvania;Perception;Performance;Physical Medicine;Physical Rehabilitation;Population;post stroke;pre-doctoral;rehabilitation science;Rehabilitation therapy;Research;Research Personnel;Resource-limited setting;Resources;Robot;robot rehabilitation;robot therapy;robotic system;Robotics;sensory feedback;skills;social;Stroke;stroke rehabilitation;stroke survivor;Survivors;System;systematic review;Tactile;Technical Expertise;Techniques;Testing;Touch sensation;Training;transmission process;Universities;usability;vibration;Visual;Work;young adult

PROJECT_TITLE: Leveraging Robot-Based Haptic Dyads to Improve Community-Based Stroke Rehabilitation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Cocaine use disorder (CUD) is defined by a variety of symptoms, including disruptions in non-drug stimulus processing. The ability to perceive and respond appropriately to environmental stimuli is necessary for many types of learning and is dependent on dopamine release in the nucleus accumbens core. The goal of this project is to define how cocaine-induced alterations in the dopamine system disrupt spatial patterns of dopamine release in response to salient stimuli, providing a framework for how chronic cocaine use can dysregulate drug and non- drug stimulus processing.

PI_NAMEs: ELAM, HANNAH  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Abstinence;Active Sites;Animals;Aversive Stimulus;awake;Behavior;behavioral impairment;Biosensor;Brain region;career;Characteristics;Chronic;Cocaine;cocaine exposure;cocaine self-administration;cocaine use;Cocaine use disorder;Complement;Complex;computerized tools;Conditioned Stimulus;Corpus striatum structure;Cues;Data;Desire for food;Disease;Dissociation;Dopamine;dopamine system;dopaminergic neuron;Drug Exposure;Drug usage;Electrophysiology (science);Endoscopy;Event;experience;Extinction;Female;Fiber;Freezing;Functional disorder;Future;Goals;Image;Impairment;in vivo;in vivo imaging;Individual;Learning;Link;machine learning algorithm;male;Measures;Microdialysis;Modality;Mus;neural;Neurobiology;non-drug;novel;Nucleus Accumbens;Optics;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Photometry;Presynaptic Terminals;prevent;Process;Quinine;Recording of previous events;Resolution;response;Rewards;Role;segregation;sensor;Severities;Signal Transduction;Stimulus;stimulus processing;success;Sucrose;Symptoms;System;Techniques;Testing;Training;transmission process;Treatment outcome;Visualization;Work

PROJECT_TITLE: Cocaine effects on spatial patterns of striatal dopamine release

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Nutrition;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Cancer patients undergoing therapy often experience taste and salivary gland disruptions, resulting in dysgeusia (taste dysfunction) and xerostomia (clinical hyposalivation). These conditions can impact the quality of life and survival outcomes for patients. The circumvallate papilla/von Ebner's salivary gland complex is an ideal model to study this, as the complex comprises taste and salivary gland tissues; this proposal seeks to understand CVP/VEG homeostasis by identifying a novel cell population, which may inform therapies to mitigate dysgeusia and xerostomia.

PI_NAMEs: ISNER, TREVOR JOSEPH (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Ablation;Acinar Cell;Adult;Affect;Anatomy;Bar Codes;Basement membrane;Bioinformatics;Brain;Cancer Patient;cancer therapy;cell type;Cells;cellular transduction;Circumvallate Papilla;Clinical;Clinical Data;Complex;Data;Development;Diphtheria Toxin;Duct (organ) structure;Dysgeusia;embryo cell;Epithelium;experience;experimental study;Functional disorder;Gene Expression Profiling;Genetic;Gland;Heterogeneity;Homeostasis;In Vitro;in vivo;Individual;Inherited;keratinization;Label;Lead;LGR5 gene;Link;Maintenance;Minor salivary gland structure;Modeling;Morphology;multipotent cell;Multipotent Stem Cells;Mus;novel;Nutritional;oral cavity epithelium;Organ;Organoids;Patient-Focused Outcomes;Patients;Population;Positioning Attribute;Preparation;Production;progenitor;Proliferating;Protocols documentation;Quality of life;Receptor Cell;Saliva;saliva secretion;Salivary;Salivary duct structure;Salivary Gland Tissue;Salivary Glands;Sensory;Serous;Signal Transduction;single-cell RNA sequencing;stem;stem cell population;stem cells;Structure;survival outcome;Taste Buds;Taste Perception;taste stimuli;taste transduction;Techniques;Testing;therapy development;Tissue-Specific Gene Expression;Tissues;Tomatoes;Tongue;Xerostomia

PROJECT_TITLE: Identifying Sox9 as a marker of multipotent progenitors in Circumvallate papilla/Von Ebner's gland homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Y (59)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Chikungunya virus is a mosquito-transmitted alphavirus that causes persistent, debilitating polyarthritis in a significant numbers of patients. Chronic disease is characterized by the persistence of viral RNA even though no replicating virus is detected. Using tools that we have developed we will work to understand which cells contain viral RNA, why it is not cleared from these cells, and how these cell types contribute to the development of this virus induced arthritis.

PI_NAMEs: DIAMOND, MICHAEL S;LENSCHOW, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acute;Acute Disease;acute infection;Adaptor Signaling Protein;Address;Affect;Africa;Alpha Virus;Americas;Arthralgia;arthritic pain;Arthritis;Asia;Automobile Driving;Caribbean region;CD4 Positive T Lymphocytes;Cell Survival;cell type;Cells;chikungunya infection;Chikungunya virus;Chronic;Chronic Disease;Chronic Phase;Chronic Phase of Disease;conditional knockout;Culicidae;cytokine;Dermis;Development;Diamond;Engineering;Enterobacteria phage P1 Cre recombinase;Epidemiology;Exanthema;Fever;Fibroblasts;Florida;Gene Expression Profile;Human;Immune;immune cell infiltrate;improved;Indian Ocean;Individual;Infection;Infection prevention;Infiltration;Inflammation;Inflammatory;insight;Joints;Knockout Mice;Laboratories;Macaca;Macrophage;Mediating;MicroRNAs;Molecular;monocyte;mouse model;Mus;Muscle;Musculoskeletal;Musculoskeletal Diseases;Mutate;Myalgia;Myositis;next generation;nonhuman primate;novel therapeutics;pathogen;Pathogenesis;Patients;Pattern;Pattern recognition receptor;Phenotype;Polyarthritides;Population;prevent;Productivity;recombinant virus;Recombinants;repaired;Reporter;Reporting;RNA;Signal Transduction;South America;Syndrome;Synovial Membrane;System;Testing;Texas;Therapeutic Intervention;Time;tissue repair;Tissues;tool;transmission process;United States;Viral Genome;Viral Pathogenesis;viral RNA;viral transmission;Virus;virus culture;virus development;Virus Diseases;Virus Receptors;Virus Replication;Work

PROJECT_TITLE: Pathogenesis of Alphavirus induced Chronic Arthritis and Myositis

STUDY_SECTION: VDT

STUDY_SECTION_NAME: Viral Dynamics and Transmission Study Section [VDT]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Over-exposure to manganese (Mn) is neurotoxic and can lead to incurable motor deficits. In this proposal, we will identify whether Mn primarily targets dopaminergic or GABAergic neurons of the basal ganglia to cause disease. Proposed work will also determine whether preventing the increase of Mn levels in specific neurons after over-exposure is sufficient to protect against Mn- induced motor disease.

PI_NAMEs: MELKOTE, ASHVINI  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;Adult;Affect;Attenuated;Basal Ganglia;Behavioral;Behavioral Assay;Biological Assay;Birth;Brain;Carrier Proteins;Cognitive deficits;comparison control;Consumption;Corpus striatum structure;Data;Disease;Dopamine;dopaminergic neuron;drinking water;Environment;Excretory function;Exhibits;experimental study;Exposure to;Functional disorder;Future;gamma-Aminobutyric Acid;Globus Pallidus;Goals;Human;Impairment;in vivo;Individual;insight;Intestines;Knock-in;Knock-in Mouse;Knockout Mice;Life;Liver;loss of function mutation;Manganese;Measures;Metals;Microdialysis;Micronutrients;Motor;motor deficit;motor disorder;mouse model;Mouse Strains;Mus;neural;neurochemistry;neuromechanism;Neurons;neurotoxic;neurotoxicity;Neurotransmitters;novel;Occupational;Oral;Parkinsonian Disorders;Pathway interactions;pediatric dystonia;Phenotype;Physiological;prevent;Prevention;Proteins;Public Health;Research;Source;Structure of subthalamic nucleus;Substantia nigra structure;Testing;Thalamic structure;therapeutic target;tool;Toxic effect;Trace metal;Whole Organism;Work

PROJECT_TITLE: Identifying neuronal targets and mechanisms of manganese-induced neuromotor disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Valley Fever

ORG_CITY: SAN ANTONIO

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: PROJECT NARRATIVE Coccidioides, a harmful fungus found in American deserts, causes Valley Fever, a severe lung infection that can travel to the bones and brain when people breath in its spores. Since existing treatments are limited and may face resistance, I am exploring a creative solution by repurposing drugs already approved by the FDA, also known as “teaching old drugs new tricks”. I hope to develop a new treatment approach by combining any of the 6 candidate drugs I identified with current antifungal medications for treating Valley Fever to make the medications more effective and to reduce the risk of resistance.

PI_NAMEs: SAEGER, SARAH BETH (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Address;Adverse effects;aerosolized;American;Amphotericin B;Analysis of Variance;Animal Model;anti-fungal agents;Area;Ascomycota;Azoles;Basidiomycota;Biological Assay;Body Weight Changes;bone;Bone Marrow;booster vaccine;Brain;Breathing;burden of illness;Candida;Caspofungin;Cell Wall;Chi-Square Tests;Clinical;Coccidioides;Coccidioidomycosis;Combination Drug Therapy;Combined Modality Therapy;comparative efficacy;cost;Creativeness;Cryptococcus;desert fever;Desertification;Disease;dosage;Dose;drug candidate;drug development;drug efficacy;drug isolation;drug repurposing;Drug resistance;Drug toxicity;Educational process of instructing;efficacy testing;Etiology;Exhibits;experimental study;Exposure to;Face;FDA approved;Flow Cytometry;flu;Fluconazole;Fluconazole resistance;Fungal Drug Resistance;fungicide;fungus;Future;Growth;Guidelines;Hyphae;Image;In Vitro;in vivo;Incidence;Individual;Infection;Inhalation;Injections;insight;Investigation;Joints;Kidney;Kinetics;Larva;life time cost;Lung;Lung infections;Mann-Whitney U Test;Measures;Metabolic;Mitochondria;Modeling;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;Mycoses;novel;novel therapeutic intervention;novel therapeutics;nucleic acid localization;Oral;Organ;oxidation;pathogenic fungus;Persons;Pharmaceutical Preparations;Pneumonia;Predisposition;Property;Qualifying;Reproduction spores;Research;Resistance;Rest;Risk;Risk Reduction;Route;scale up;screening;Skin;Soil;Spleen;success;Surveys;Symptoms;synergism;Testing;Therapeutic;Time;Toxic effect;Travel;treatment comparison;Treatment Efficacy;Triazoles;United States;Vaccines;Variant;Weight;Work;Zygomycota

PROJECT_TITLE: Repurposing Drugs to Discover Novel Antifungals for Coccidioidomycosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative The proper organization of DNA within the nucleus is required for normal genome functions and is disrupted in many diseases. Here we will describe the consequences of a direct interaction between a genome organizer called ESCO1 and chromatin. This study will improve our knowledge of how chromosome organization is controlled so that we can better understand how disruptions in the chromosome landscape impact cellular function.

PI_NAMEs: SCHOEN, JEFFREY R. (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Acetylation;Acetyltransferase;Affinity;Automobile Driving;base;Binding;Biochemical;Biological;Biological Assay;Cell Nucleus;Cell Physiology;Cells;Chromatin;Chromatin Loop;Chromatin Structure;chromosome replication;Chromosome Structures;Chromosomes;cohesin;Complex;crosslink;CSPG6 gene;Data;Defect;Disease;DNA;DNA Binding;DNA biosynthesis;DNA Repair;DNA-Binding Proteins;Enzymes;experimental study;Fluorescence Microscopy;Fluorescent in Situ Hybridization;Gene Expression;Genes;Genetic Transcription;Genome;Histones;improved;In Vitro;Knowledge;Location;Maps;Measures;Mediating;Modeling;Modification;N-terminal;Names;Nuclear;Phenotype;Physical condensation;Proteins;recruit;residence;System;Tail;Techniques;Testing;Time;Work

PROJECT_TITLE: Defining a direct mechanism of ESCO1 in chromatin organization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering;Obesity

ORG_CITY: BERKELEY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: The obesity epidemic remains one of the greatest public health challenges faced by the United States and disproportionately affects Non-Hispanic Black adults and Hispanic adults. Regulation and activation of thermogenic adipocytes has been an active area of study due to the cells' high metabolic rates and ability to dissipate both glucose and fatty acids as heat as well as their secretion of insulin sensitizing hormones. This project addresses how biomechanical forces from the inside of the cell affect differentiation decisions and metabolic activity and how the biointerface between these intracellular forces and extracellular mechanical forces is regulated by the protein focal adhesion kinase.

PI_NAMEs: KUMAR, SANJAY ;STAHL, ANDREAS  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: 3-Dimensional;Actomyosin;Address;Adhesions;adipocyte differentiation;Adipocytes;Adipose tissue;Adrenergic Agents;Adult;Affect;Area;beta-adrenergic receptor;Biomechanics;Black race;Brown Fat;Cardiac;Catecholamines;Cell Nucleus;Cell Physiology;Cells;Cues;Cyclic AMP-Dependent Protein Kinases;Data;Dependence;Environment;Event;extracellular;Extracellular Matrix;Fatty Acids;Focal Adhesion Kinase 1;Generations;Glucose;Goals;Hispanic;Hormones;Hyaluronic Acid;In Vitro;in vivo;insulin secretion;Integrins;Kinetics;L-Type Calcium Channels;Ligands;Link;mechanical force;Mechanics;Metabolic;metabolic rate;Mitochondria;Molecular;MYLK gene;Myosin ATPase;Myosin Heavy Chains;Myosin Light Chain Kinase;non-muscle myosin;Not Hispanic or Latino;Obesity Epidemic;Outcome;permissiveness;Physiologic pulse;programs;Property;Proteins;Public Health;Receptor Activation;Receptor Signaling;Regulation;Role;Shapes;Signal Pathway;Signal Transduction;skeletal;Source;spatiotemporal;System;Thermogenesis;United States;viscoelasticity;Work

PROJECT_TITLE: Role of Biomechanical Interfaces Created by Focal Adhesion Kinase in Catecholamine Signaling

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Sepsis

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative Bacterial diseases constitute a major global burden, primarily due to respiratory, peritoneal, and blood infections. In this proposal, we will test our hypothesis that a newly discovered acid-sensitive chloride channel, proton- activated chloride channel 1 (PACC1), may provide protection by promoting myeloid cell responses during bacterial infection—especially from tissue-resident alveolar macrophages—possibly by supporting phagolysosomal acidification and bacterial killing. Our innovative approach will leverage multiple bacterial pathogens (Streptococcus pneumoniae, Escherichia coli); organ systems (lung, peritoneum); novel myeloid cell conditional PACC1 knockout and PACC1 overexpression mouse strains generated by our lab; and transcriptomics, to elucidate the role of PACC1 in pneumococcal pneumonia and sepsis, all while serving as an integrated training plan for my development as an independent pulmonary immunology researcher.

PI_NAMEs: GARO, LUCIEN PETER (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acidity;Acidosis;Acids;Alveolar;Alveolar Macrophages;Anions;Antibodies;Bacteremia;Bacteria;Bacterial Infections;Bacterial Pneumonia;Biological;Biological Process;Biology;Blood;Body System;Carrier Proteins;Cell Death Induction;Cell Physiology;cell type;Cells;Cessation of life;Chloride Channels;Chlorides;Clinical;Companions;Cytolysis;Data;Defect;Development;Diffusion;Disease;disease model;Environment;Escherichia coli;Escherichia coli Infections;experimental study;extracellular;Goals;Health;Histopathology;Host Defense;Immune;Immune response;Immunity;Immunologics;Immunology;Impairment;improved;In Vitro;in vivo;Incubated;Infection;Innate Immune Response;innovation;Integral Membrane Protein;Intervention;Ions;Ischemia;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Label;Lead;Lung;Lung infections;Macrophage;Mammals;Mediating;Membrane;microbial;Mouse Strains;Movement;Mus;Myelogenous;Myeloid Cells;Natural Immunity;neutrophil;Neutrophil Infiltration;novel;overexpression;pathogen;pathogenic bacteria;Pathologic;Pathway interactions;Peritoneal;Peritoneal Macrophages;Peritoneum;Phagocytes;Phagocytosis;Phagolysosome;Physiological;Play;Pneumococcal Infections;Pneumococcal Pneumonia;Pneumonia;Predisposition;Protein Analysis;Proteolysis;Proton Pump Inhibitors;Protons;recruit;Research Personnel;Resistance;respiratory;Respiratory Burst;response;Role;Sepsis;Severities;Signal Transduction;Streptococcus pneumoniae;targeted treatment;Testing;Tissues;Training;transcriptome sequencing;transcriptomics;uptake;Wild Type Mouse

PROJECT_TITLE: The Role of Proton-Activated Chloride Channel 1 (PACC1) in Bacterial Pneumonia and Sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


PHR: PROJECT NARRATIVE Through this work we will establish the utility of COSMIIC power and stimulation modules for controlling multi- contact cuff electrodes in a manner that yields selective bladder neuromodulation in a sub-chronic ovine model.

PROJECT_TERMS: Accelerometer;Affect;Anesthesia procedures;Animal Model;Animals;awake;Bladder;Bladder Control;Bladder Dysfunction;Clinical;clinical translation;clinically relevant;Data;Distal;Electric Stimulation;Electrodes;Electromyography;Esthesia;Etiology;FDA approved;Female;Functional disorder;Funding;Future;Genitalia;Health Care Costs;Home;Human;Immobilization;Implant;improved;Incontinence;Individual;interest;Limes;Location;Lower urinary tract;lower urinary tract symptoms;men;Methods;Monitor;Nerve;Nerve Fibers;neural circuit;Neural Pathways;neuroregulation;Operative Surgical Procedures;Organ;Overactive Bladder;Pathology;Pathway interactions;patient screening;Patients;Penetration;Persons;pharmacologic;Pharmacotherapy;Positioning Attribute;Pre-Clinical Model;preclinical study;pressure;receptor;recruit;Relaxation;Reporting;research clinical testing;response;Sacral nerve;Sheep;sheep model;Sphincter;Spinal nerve root structure;Sterility;System;Testing;treatment response;Urethra;Urinary Incontinence;Urination;Woman;Work

PROJECT_TITLE: Selective stimulation of lower urinary tract function in ovine


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Sleep Research;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative Fetal Alcohol Spectrum Disorder (FASD) is the most prevalent preventable neurological disorder affecting children in the United States. Individuals with FASD commonly experience learning and memory deficits. This proposal uses a mouse model to investigate the underlying mechanisms of these deficits, and successful completion of this work will provide valuable information for further research and therapeutic routes.

PI_NAMEs: MYRICK, ABBEY  (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Active Learning;Address;Affect;alcohol exposure;Alcohols;Algorithms;analytical tool;Animals;Apoptosis;awake;Behavioral;Brain;career;Characteristics;Child;Classification;Code;Collection;Communication;Data;Data Collection;Development;Diagnosis;Electrodes;Electrophysiology (science);Equilibrium;Event;experience;Fetal Alcohol Spectrum Disorder;Fetus;Frequencies;Functional disorder;Goals;Head;High Frequency Oscillation;Hippocampus;Hour;Implant;implantation;in vivo;Individual;inhibitory neuron;Interneurons;Intervention;Knowledge;Learning;Learning Disorders;life span;Literature;Memory;memory consolidation;memory encoding;Memory impairment;mouse model;Mus;Nervous System Disorder;neural;neural patterning;neural recruitment;Neurodevelopmental Disorder;Neurologic;neuron loss;neuronal patterning;Neurons;non rapid eye movement;Operative Surgical Procedures;optogenetics;Outcome;Pattern;Performance;Phase;Population;Population Dynamics;Pregnancy;Process;recruit;Research;Retrieval;Role;Route;Sleep;Sorting;spatial memory;Synapses;Testing;Therapeutic;therapeutic development;Third Pregnancy Trimester;tool;Training;Travel;treatment group;United States;way finding;Work;Writing

PROJECT_TITLE: The Impact of Third Trimester Alcohol Exposure on Memories Encoded by Sharp-Wave Ripples of the Hippocampal-Retrosplenial Cortex Circuit

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: PROJECT NARRATIVE Noroviruses are a top cause of gastroenteritis worldwide. This proposal seeks to understand at the molecular level how antibodies bind to the norovirus capsid and block infectivity, and how virus evolution affects these interactions. These findings will be important for understanding key vulnerabilities of the virus and developing a vaccine to prevent norovirus disease.

PI_NAMEs: DUBOIS, REBECCA MICHELLE (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;Affect;Amino Acids;Animals;Antibodies;Antigen-Antibody Complex;Antigenic Diversity;Antigenic Variation;Antigens;Binding;Biological Assay;biophysical techniques;Biophysics;Blocking Antibodies;Capsid;Capsid Proteins;Carbohydrates;Cells;Cessation of life;Chronology;Collaborations;Complex;Data;Data Collection;design;Development;Disease;Disease Outbreaks;Electron Microscopy;Epitope Mapping;Epitopes;Evolution;FDA approved;Foundations;Gastroenteritis;Genetic;Genetic Variation;Genomic approach;Genomics;Genotype;Goals;Health;Human;Immune;immune imaging;Immunize;Immunoassay;Immunodominant Epitopes;Infection;innovation;insight;Intestines;Knowledge;Maps;Molecular;Monoclonal Antibodies;Mutagenesis;mutant;Names;neutralizing antibody;neutralizing monoclonal antibodies;Norovirus;novel;Outcome;Play;polyclonal antibody;Preparation;pressure;prevent;Publications;Research;Resolution;Sampling;Serology;Serum;Site;Specificity;Structure;Techniques;Trefoil Motif;vaccine development;Vaccines;Variant;Virus;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Structural mapping of an immunodominant antigenic site on the norovirus capsid

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This study will examine the independent and interactive contributions of cerebrovascular disease, neuroinflammation, and blood-brain barrier (BBB) disruption to cognitive decline and the progression of Alzheimer’s disease (AD) pathophysiology in adults with Down syndrome (DS). Virtually all adults with DS develop AD and progress to dementia by age 60, but the mechanisms are poorly understood. Through rigorous examination of the relationships of cerebrovascular disease, neuroinflammation, and BBB disruption with AD pathophysiology and cognitive outcomes, using neuroimaging, biofluid, and neuropathological markers, this study has the potential to contribute to our understanding of the pathways underlying AD in adults with DS and the neurotypical population.

PI_NAMEs: EDWARDS, NATALIE CATHERINE (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Address;Adult;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid beta-Protein;Ancillary Study;Astrocytosis;Autopsy;Biological;Biological Markers;Biology;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-based biomarker;blood-brain barrier disruption;California;career;career development;cerebrovascular;Cerebrovascular Disorders;cerebrovascular lesion;Cerebrovascular system;clinical diagnosis;Cognitive;Collaborations;comorbidity;Cross-Sectional Studies;Data;Data Set;Dementia;design;Development;Diagnosis;Disease;Disease Progression;Down's Syndrome;Exhibits;experience;Fellowship;Functional disorder;Genetic;Glial Fibrillary Acidic Protein;Head;Histopathology;Impaired cognition;Indiana;Individual;Inflammation;Inflammatory;inflammatory marker;Infrastructure;Injury;insight;Kentucky;Knowledge;Knowledge acquisition;Late Onset Alzheimer Disease;Longitudinal cohort study;Low Prevalence;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Mediating;Mentorship;Metalloproteases;Methodology;Microvascular Dysfunction;multimodality;National Research Service Awards;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;neuroimaging;neuroinflammation;neuropathology;Neuropsychological Tests;Neuropsychology;neurovascular unit;novel;Observational Study;Outcome;Participant;Pathogenesis;Pathology;Pathway interactions;Peripheral;Persons;PGF gene;Plasma;Play;Population;Positioning Attribute;pre-clinical;Prevention strategy;Process;Public Health;Recording of previous events;Research;Resources;Risk;Role;Severity of illness;skills;Symptoms;tau Proteins;Techniques;Testing;Training;Translational Research;treatment strategy;United States National Institutes of Health;Universities;Vascular Diseases;vascular factor;vascular risk factor;virtual;White Matter Hyperintensity

PROJECT_TITLE: Synergistic contributions of cerebrovascular disease and neuroinflammation to Alzheimer's disease in adults with Down syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Vagus Nerve Somatotopy using the COSMIIC System  In this Supplement, we will use the COSMIIC Platform System components to assess the impact of chronic fibrous encapsulation on evoked recording from the cervical vagus nerve immediately post-implant and chronically over time.

PI_NAMEs: CHESTEK, CYNTHIA ANNE;KILGORE, KEVIN L. (contact);SMITH, BRIAN

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: 3-Dimensional;Acute;Address;Adrenergic Fibers;Anesthesia procedures;Animal Model;Animals;Autopsy;awake;Blood Pressure;Cervical;Chronic;Cicatrix;Clinical;Clinical Trials;cohort;Coughing;Data;design;Devices;Diameter;Dose;Dyspnea;Efferent Pathways;Electrodes;Electromyography;Encapsulated;Failure;Family suidae;Fascicle;Fiber;Future;habituation;Heart failure;Heart Rate;Histology;Human;Image;Implant;Left;Location;Maps;Marketing;Measurement;Mediating;Motor;Motor Pathways;Muscle;Myocardial dysfunction;Nerve;Neural Pathways;Operative Surgical Procedures;Optical Coherence Tomography;Pain;Pathway interactions;Patients;Perioperative;Pharyngeal structure;Physiological;Positioning Attribute;Procedures;Reporting;response;Sensory;side effect;Skeletal muscle structure of neck;Structure of superior cervical ganglion;System;Therapeutic;Therapeutic Effect;three-dimensional modeling;Time;Transducers;ultrasound;vagus nerve stimulation;Vagus nerve structure;Voice

PROJECT_TITLE: Exploiting somatotopy within the cervical vagus in a chronic large animal model


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of new mechanisms that regulate energy homeostasis and nutrient metabolism will provide novel insights into the pathogenesis of obesity-related disorders. The proposed studies are relevant to the mission of the NIDDK because they are expected to identify new therapeutic targets for the management of metabolic dysfunction-associated steatotic liver disease.

PI_NAMEs: COHEN, DAVID E. (contact);HAGEN, SUSAN J;ORTLUND, ERIC A

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Acyl Coenzyme A;Address;Adipose tissue;Binding;Biochemical;biophysical techniques;blood glucose regulation;Brown Fat;Calories;Cell Culture System;Cell membrane;Cell Nucleus;Consumption;Cytoplasm;Data;design;Development;Disease;Energy Metabolism;Enzymatic Biochemistry;Enzymes;experimental study;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Fatty Liver;feeding;Gene Expression Profile;Genes;Genetic Transcription;Gluconeogenesis;Glucose;glucose production;Goals;Health;Hepatic;High Fat Diet;Homeostasis;Human;insight;Insulin Resistance;Lipid Binding;Lipids;Liver;Liver diseases;liver metabolism;Lysophosphatidylcholines;Mediating;Medication Management;member;Membrane;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Mission;Mitochondria;Molecular;mouse model;Mus;mutant;Names;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;novel;Nuclear;Nuclear Localization Signal;Nutrient;nutrient metabolism;Obesity;Outcome Study;Overnutrition;oxidation;Pathogenesis;Pathogenicity;Pathway interactions;Physical condensation;Physiological;Process;Public Health;Recombinant adeno-associated virus (rAAV);Regulation;Research;Research Proposals;Resistance;response;Rodent;Role;steroidogenic acute regulatory protein;Structure;Temperature;Testing;Therapeutic;Thermogenesis;tissue culture;Tissues;trafficking;Transcriptional Regulation;Triglyceride Metabolism;Triglycerides;Up-Regulation

PROJECT_TITLE: Them1-Mediated Metabolic Regulation and Pathogenic Role in MASLD

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Genetics;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: SYRACUSE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD), the most common form of dementia, is diagnosable based on a combination of clinical and biological indicators that generally exhibit consistency across patients, such as cognitive decline and memory impairment; however, substantial variability in the onset, progression, and manifestation of the disease among individuals poses significant challenges for early detection and management of AD. The objective of this proposal is to establish a computational model that can accurately identify distinct subgroups among AD patients based on gene activity patterns in the brain, all achieved non-invasively by neuroimaging techniques. Successful completion of this project will help reveal genetic pathways in the brain associated with the progression of AD, paving the way to identify new treatment targets and prevention strategies for this debilitating disease.

PI_NAMEs: MIKHAILOVA, TATIANA  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Address;Affect;Age;aging population;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease patient;Applications Grants;Automobile Driving;Biological;Biological Markers;Brain;cancer subtypes;Cerebrospinal Fluid;Characteristics;Classification;Clinical;Cognition;cohort;Computer Analysis;Computer Models;Cytosine;Data;data modalities;Dementia;design;Development;diagnostic criteria;Disease;disease heterogeneity;Disease Pathway;disease phenotype;Disease Progression;disorder subtype;diverse data;DNA;DNA Methylation;DNA Modification Methylases;Early Diagnosis;Enzymes;Epigenetic Process;Exhibits;Foundations;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic risk factor;Genetic Transcription;Genotype;Goals;Heterogeneity;Image;Impaired cognition;improved;Individual;Investigation;Knowledge;Literature;Machine Learning;machine learning algorithm;machine learning prediction algorithm;Magnetic Resonance Imaging;Malignant Neoplasms;Memory;Memory impairment;Messenger RNA;Methodology;Methylation;methylation biomarker;MicroRNAs;Molecular;Molecular Analysis;molecular marker;Molecular Profiling;molecular subtypes;multiple omics;Neurodegenerative Disorders;neuroimaging;new therapeutic target;Onset of illness;Pathway interactions;patient subsets;Patients;Pattern;Phenotype;Play;predictive modeling;Prevention strategy;Proteins;Reproducibility;Research;Research Proposals;Role;structural imaging;Subgroup;Techniques;therapeutically effective;Training;Translations;Untranslated RNA

PROJECT_TITLE: Advancing Alzheimer's Diagnosis: MRI-Based Predictive Modeling of Alzheimer’s Disease Molecular Subtypes


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Aging in different species involves certain mechanisms that need to be understood for us to therapeutically slow the aging process. In a well-studied model of aging in the yeast S. cerevisiae, we have made the surprising observation that there is a marked increase in accumulation of fragments of tRNAs, and in misprocessing of tRNA transcripts. In this proposal we will determine if these cleaved tRNA fragments or the extended tRNA products that accumulate during aging contribute to the aging process.

PI_NAMEs: DUTTA, ANINDYA  (contact);SMITH, JEFFREY SCOTT

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;Affect;Age;age related changes;aged;Aging;aging mechanism;aging process;aging related;Anticodon;Biogenesis;Biological Process;Cells;Cellular biology;Cellular Stress;Chronology;Collaborations;Complex;Defect;Eukaryota;Family;Future;Genes;Genetic Transcription;gerotherapeutic;hallmarks of aging;Health;insight;Investigation;Label;Left;life span;Link;Longevity;Mediating;Messenger RNA;MicroRNAs;model organism;Mutation;novel;Organism;overexpression;Phenotype;Process;Protein Biosynthesis;protein function;Protein Synthesis Inhibition;proteostasis;proteostasis loss;Regulation;Reporting;RNA;RNA Polymerase III;Role;Saccharomyces cerevisiae;Site;Small RNA;Solid;Study models;System;Testing;Transcript;Transcription Initiation;transcription termination;Transfer RNA;tRNA Precursor;Yeasts

PROJECT_TITLE: tRNA-derived short and long RNAs in aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-S (02)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Immunotherapy;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: NARRATIVE A recent HNSCC clinical trial using radiation and aPDL1 resulted in excellent response rates, but when combined with a different aPDL1 or when another checkpoint blockade was added to RT and aPDL1, the same trial resulted in nodal progression and halting of the latter two trials. Having identified Tregs in our preliminary preclinical and clinical data as key component mediating this phenomenon, we will focus on tackling aspects of Tregs' activation, signaling, fragility, and trafficking, in the hope that it will lead to novel therapeutic approaches that mitigates cancer immune evasion within the draining lymph node.

PI_NAMEs: KARAM, SANA D (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Agonist;Animal Model;antagonist;anti-CTLA4;anti-PD-L1;Area;Bioenergetics;Blood Vessels;cancer cell;cancer clinical trial;CD8B1 gene;Cells;checkpoint inhibition;Clinical;Clinical Data;Clinical Trials;Combination immunotherapy;conditional knockout;Consumption;Cytometry;Data;Disease;Distant Metastasis;draining lymph node;Environment;Event;Failure;Funding;Future;Genetic;Genetic Engineering;Genetically Engineered Mouse;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;High Endothelial Venule;Human;human tissue;Immune;immune checkpoint blockade;Immune Evasion;Immune response;Immunity;Immunofluorescence Immunologic;Immunologic Memory;Immunosuppression;Immunotherapy;implantation;Infiltration;Inflammation;inhibitor;irradiation;knock-down;Knock-out;Ligands;lymph nodes;Lymphatic;lymphotoxin beta receptor;Malignant Neoplasms;Mediating;metabolomics;Modeling;Morphology;mouse model;multiple omics;Mus;Natural History;Neoadjuvant Therapy;Neoplasm Metastasis;Nodal;novel therapeutic intervention;Outcome;Pathologic;Pathway interactions;Patients;Pattern;pharmacologic;Phase;Phase II Clinical Trials;postcapillary venule;pre-clinical;Pre-Clinical Model;preservation;prevent;Primary Neoplasm;programmed cell death ligand 1;programmed cell death protein 1;Property;Proteins;Proteomics;Publishing;Radiation;radiation response;Recombinants;Recurrence;Regulatory T-Lymphocyte;Research;Resistance;response;Risk;Signal Transduction;single-cell RNA sequencing;Specimen;standard of care;STAT3 gene;T-Lymphocyte;Testing;Therapeutic;therapy resistant;Time;Tissues;trafficking;tumor;Tumor Escape;tumor growth;Tumor Promotion;tumor-immune system interactions;Up-Regulation;Work

PROJECT_TITLE: Tackling Treg mediated resistance to radiation and anti-PDL1 in HNSCCs

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Adolescent traumatic brain injury (TBI) can lead to negative health outcomes in youth populations such as increased mental health symptoms and early life substance misuse, which can lead to substance misuse- related disorders later in life. The present study will examine how impulsivity characteristics, TBI, and mental health symptoms may predict later substance use behaviors from ages 9 through 14 in a large longitudinal cohort study. Results will provide a better understanding of the impact of TBI on substance misuse behaviors in adolescents and inform future clinical interventions.

PI_NAMEs: DELFEL, EVERETT LEE (contact)

PROGRAM_OFFICER_NAME: COLLIER KIDEMU, KEVA WONTORIA

PROJECT_TERMS: 10 year old;14 year old;Accident and Emergency department;addiction;Adolescence;Adolescent;Adolescent and Young Adult;Adolescent Development;adolescent substance use;Age;Alcohol consumption;Alcohols;Anxiety;Anxiety Disorders;Behavior;Behavioral;Brain;Brain region;Cannabis;Caring;Characteristics;Child;Clinical;Clinical Treatment;cognitive development;cohort;Cohort Studies;Data;Data Set;Depressive disorder;depressive symptoms;Development;Disease;Early identification;eighth grade;Emergency department visit;Emotional;Enrollment;Esthesia;Exanthema;experience;externalizing behavior;Family;Foundations;frontal lobe;Functional disorder;Future;Goals;Health;Impulsivity;Individual;Injury;Intervention;Life;Link;Literature;Longitudinal cohort study;Mediating;Mediation;Mediator;Mental Depression;Mental disorders;Mental Health;Modeling;modifiable risk;Nicotine;novel;Outcome;Personality;Personality Assessment;Personality Traits;poor health outcome;Population;Prevention;Prevention strategy;Problem behavior;prospective;Psychopathology;Puberty;Recording of previous events;Reporting;Rewards;Risk;Risk Behaviors;Risk Factors;Risk Taking;Sampling;substance misuse;substance use;Symptoms;therapy development;trait impulsivity;Traumatic Brain Injury;twelfth grade;United States;Youth

PROJECT_TITLE: Traumatic Brain Injury, Mental Health Functioning, and Substance Misuse Among Youth from the ABCD Cohort.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Genetic Testing;Genetics;Human Genome;Infertility;Pediatric;Pregnancy;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

PHR: NARRATIVE One in every 20 couples suffer from recurrent pregnancy loss (RPL) where after current clinical testing including short-read genome-wide sequencing no reason is found for half of these cases. We seek to understand how long-read technologies can fill the gaps and advanced interpretation of genetic variation to give answers to families experiencing pregnancy losses and establish a resource for the medical community to enhance diagnosis and future treatment.

PI_NAMEs: GRUNDBERG, ELIN  (contact);PASTINEN, TOMI

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Age;Alleles;Aneuploidy;base;biobank;Biological;Blood;Catalogs;Child;Childhood;Classification;Clinical;clinical diagnosis;clinical diagnostics;clinical practice;Clinical Services;clinically actionable;Collection;Communities;Complex;Computerized Medical Record;Conceptions;Couples;Cytosine;Data;data integration;data resource;Defect;Detection;Development;Diagnosis;DNA;early pregnancy loss;Electronic Health Record;Enrollment;Environmental Risk Factor;epigenetic marker;Epigenetic Process;epigenome;epigenomics;Ethnic Origin;Evaluation;Event;Exclusion;exome;exome sequencing;experience;Family;father role;Female;fetal;Fetal Development;Fetal Viability;fetus cell;Future;General Population;Generations;Genes;Genetic;Genetic Counseling;Genetic Determinism;Genetic Diseases;genetic disorder diagnosis;genetic pedigree;genetic testing;genetic variant;Genetic Variation;Genome;genome resource;genome sequencing;genome-wide;genomic profiling;Genomics;Germ Cells;Germ Lines;Goals;Health system;Hospitals;Human Development;imprint;Infertility;Inherited;insight;Karyotype determination procedure;Laboratories;Lesion;Link;male;Male Infertility;Maps;Medical;men;Methylation;Mining;Molecular;Molecular Diagnosis;molecular diagnostics;mosaic;Mosaicism;Mothers;next generation sequencing;novel;novel diagnostics;Parents;Pathway interactions;Patients;Phenotype;population based;Predisposing Factor;Pregnancy;Pregnancy Histories;Pregnancy loss;proband;programs;Property;prospective;Race;Rare Diseases;rare genetic disorder;Recording of previous events;Recurrence;Research;research clinical testing;Resolution;Resources;Running;Sampling;Single Nucleotide Polymorphism;Specimen;sperm cell;Spontaneous abortion;Standardization;Technology;Testing;Time;transmission process;Trauma;treatment strategy;ultra high resolution;Untranslated RNA;Variant;whole genome;X Inactivation

PROJECT_TITLE: 5-base HiFi sequencing to advance the understanding of genetic determinants of pregnancy loss

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-C (02)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE Basal cells are progenitor cells for multiple organs of the body that differentiate into specific cell types for each organ. In this study, I aim to investigate how genetic and epigenetic mechanisms determine the specificity of these differentiation programs in basal cells of the airways in the lung. Specifically, I plan to target genetic and epigenetic modifiers in mouse airway basal cells to identify potential targets that prevent abnormal differentiation and associated organ dysfunction and diseases.

PI_NAMEs: DIRVIN, BROOKE GREER (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Address;Adopted;Adult;adult stem cell;airway epithelium;Animal Model;Antibodies;Automobile Driving;Basal Cell;Biological Assay;Biological Products;candidate identification;cell behavior;Cell Culture Techniques;Cell Differentiation process;Cell Separation;cell type;Cells;Characteristics;Chromatin;Chromatin Remodeling Factor;Chronic;Chronic Obstructive Pulmonary Disease;cigarette smoke;Coupled;CRISPR screen;CRISPR/Cas technology;Data;daughter cell;Defense Mechanisms;Development;differential expression;Disease;Endoderm;Environment;environmental agent;Epigenetic Process;epigenomic profiling;epithelial stem cell;Epithelium;Equilibrium;Esophagus;Excision;experimental study;exposure to cigarette smoke;extracellular;Failure;Functional disorder;Gene Expression Profile;Gene Expression Profiling;Generations;Genes;Genetic;Genetic Markers;Genetic Transcription;Genomic DNA;Genomics;Goals;Growth Factor;Guide RNA;Histones;Homeostasis;Immune;In Vitro;in vivo;Inhalation;Inherited;Injury;insight;Knowledge;lentiviral-mediated;Lesion;Libraries;loss of function;Lung;Maintenance;Metaplasia;Minor;Morphology;Multipotent Stem Cells;Mus;neoplastic;Organ;Organism;particle;Pathologic;Pattern;Phenotype;Post-Translational Protein Processing;prevent;Prevention;Primitive foregut structure;progenitor;programs;Proliferating;Promoter Regions;Proteins;Protocols documentation;Pseudostratified Epithelium;Regulatory Element;repaired;Reporting;Research Project Grants;Resistance;respiratory;Respiratory System;RNA library;Screening Result;self-renewal;Signal Transduction;Site;Skin;small molecule;Specificity;Squamous cell carcinoma;Squamous Metaplasia;stem cell population;stem cells;Stimulus;Stratified Squamous Epithelium;Testing;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Tretinoin

PROJECT_TITLE: Investigating the Genetic and Epigenetic Control of Basal Cell Identity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Mycobacterium tuberculosis (Mtb) infection is the leading cause of death due to infection globally. This epidemic is exacerbated by the rise in drug-resistant TB cases, making it clear that we need new strategies to fight these infections. The proposed studies will develop novel antimycobacterials to be used in the treatment of drug- sensitive and drug-resistant TB.

PI_NAMEs: ROY, SUDESHNA ;STALLINGS, CHRISTINA LEIGH (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Acute;Address;Anabolism;Antibiotic Therapy;Antibiotics;Antimycobacterial Agents;Antitubercular Antibiotics;aqueous;Azoles;Biological;Biological Availability;Biology;Cause of Death;Cessation of life;Chemicals;Clinical;Coenzymes;combat;Combined Antibiotics;cytotoxicity;Data;Development;Diamond;Drug Combinations;drug development;Drug Evaluation;Drug resistance;Drug resistance in tuberculosis;drug-sensitive;Epidemic;experimental study;fighting;Gene Expression;Genes;Hydrogen Bonding;improved;In Vitro;in vitro testing;in vivo;indexing;Infection;inhibitor;insight;isoniazid;Lead;lead optimization;Libraries;Link;Liver Microsomes;Lung infections;Macrophage;Measurement;Metabolic;meter;Methods;Modeling;Modification;Morphology;mouse model;Moxifloxacin;Mus;mutant;Mutation;Mycobacterium tuberculosis;New Agents;Nitroimidazoles;Nitroreductases;novel;Oral;outcome prediction;Pathogenesis;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;pharmacophore;Phenotype;Physiology;pre-clinical;Prodrugs;Property;Proteins;Pyrrolidines;Relapse;Resistance;resistance mechanism;resistant strain;response;Rifampin;Safety;scaffold;Series;Solubility;standard of care;structural determinants;Structure;Structure-Activity Relationship;success;Testing;Therapeutic;Translating;Translations;Triazoles;Tuberculosis;tuberculosis treatment

PROJECT_TITLE: Development of 1,2,4-Triazolyl Compounds and their derivatives as a New Treatment for Tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-T (90)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cervical Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Radiation Oncology;Women's Health Research

PHR: PROJECT NARRATIVE Despite significant advances in disease prevention and screening, cervical cancer continues to be an important worldwide public health problem. The major goal of this study is to develop a comprehensive and robust computational model for prediction of cervical cancer treatment response and outcomes. The prognostic model will form a solid basis for individualized care of cervical cancer patients based on predicted treatment response, and further, our work is expected to discover the correlations among multimodal data, leading to dynamic patient stratification to support adaptive treatment strategies.

PI_NAMEs: LI, HUA  (contact);WANG, XIAOWEI

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;Belief;Biological Markers;cancer biomarkers;Cancer Patient;cancer therapy;Cellular Structures;Cervical;Characteristics;chemoradiation;Clinical;clinical application;clinical decision-making;Clinical Treatment;clinically relevant;cohort;Computer Models;Data;data modalities;Decision Making;deep learning;disorder prevention;Future;generative adversarial network;Goals;Heterogeneity;histological image;Image;imaging biomarker;improved;Individual;Institution;Learning;Magnetic Resonance Imaging;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Methods;Microscopic;Modeling;Monitor;multimodal data;multimodality;Nature;Neoplasm Metastasis;Network-based;neural network;neural network classifier;Organism;Outcome;Patient Care;patient stratification;patient variability;Patient-Focused Outcomes;Patients;Pattern;Performance;personalized care;personalized medicine;personalized strategies;Phenotype;Play;Positron-Emission Tomography;predict clinical outcome;Prediction of Response to Therapy;predictive modeling;Prognosis;prognosis biomarker;prognostic;Prognostic Marker;prognostic model;prognostic value;prospective;Public Health;Radiation Tolerance;radiological imaging;Recurrent tumor;Reporting;response;Retrospective Studies;RNA;Role;screening;self-attention;serial imaging;Site;Solid;specific biomarkers;survival outcome;Techniques;Testing;theories;Therapeutic;Tissues;Training;Treatment outcome;treatment response;treatment strategy;tumor;tumor growth;tumor microenvironment;tumor progression;Uncertainty;Work;X-Ray Computed Tomography

PROJECT_TITLE: Combined Imaging and RNA Analyses to Develop Cervical Cancer Biomarkers

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Every step of development relies on the dynamic regulation of gene expression. The goal of my research is to delineate mechanisms by which long non-coding RNAs (lncRNAs) recruit chromatin-modifying (i.e., epigenetic) enzymes to regulate gene expression. The mechanisms established in this study will identify a paradigm that will guide studies of other lncRNAs, RBPs, and silencing enzymes, which themselves are critical for embryonic development.

PI_NAMEs: ABRASH, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Affinity;Binding;Biochemical;Biological Assay;Biology;career;Cells;Chromatin;Collaborations;Complex;Computational Biology;Computer Analysis;Data;density;design;Development;Developmental Biology;Disease;dosage;Dosage Compensation (Genetics);Electrostatics;Elements;Embryonic Development;Enzymes;Epigenetic Process;epigenetic silencing;experimental study;Family;Fellowship;Gene Expression;Gene Expression Regulation;gene repression;Gene Silencing;Genes;Genomics;Goals;Heterogeneous-Nuclear Ribonucleoproteins;In Vitro;in vivo;insight;Institution;Maps;Mediating;member;Modeling;Molecular;Multienzyme Complexes;mutant;Mutation;oral communication;Play;PRC1 Protein;Pre-implantation Embryo Development;Principal Investigator;Process;Property;protein protein interaction;Proteins;Quantitative Microscopy;reconstitution;recruit;Repression;Research;RNA;RNA Binding;RNA Biochemistry;RNA Sequences;RNA-Binding Proteins;Role;Series;Site;Structure;Study Skills;Tertiary Protein Structure;Testing;Time;Training;Untranslated RNA;Work;Writing;X Chromosome;X Inactivation

PROJECT_TITLE: Decoding Repression: Recruitment of epigenetic silencers by RNA binding proteins and long non-coding RNAs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Pediatric

ORG_CITY: Portland

ORG_NAME: PEDIATRIC DERMATOLOGY RESEARCH ALLIANCE, INC

ORG_STATE: OR

PHR: PROJECT NARRATIVE Established in 2012, the Pediatric Dermatology Research Alliance (PeDRA) is a nonprofit research organization driven by the mission to create, inspire, and sustain research to prevent, treat, and cure childhood skin disease, and the PeDRA Annual Conference has been integral to the organization’s growth and success since the first conference in 2013. In 2024, its twelfth annual conference will continue PeDRA’s work to educate and empower physician-scientists, trainees, and other stakeholders through an agenda that disseminates results, supports the identification of high-priority questions, and facilitates science with a focus on innovative solutions to advance pediatric dermatology research. The conference will accelerate the pace of pediatric dermatology research in pursuit of PeDRA’s vision of changing lives and healing children with skin disease through collaboration and discovery.

PI_NAMEs: FERNANDEZ  FAITH, ESTEBAN ;SIEGEL, MICHAEL  (contact);YU, JIA DE

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acceleration;Address;Advocate;Area;Attention;Automobile Driving;career;Caregivers;Caring;Child;Child Welfare;Childhood;Clinical;Collaborations;comorbidity;Competence;Data;Data Analyses;Dermatology;Development;Discipline;Disease;Disease Management;Education;empowerment;evidence based guidelines;Exposure to;Family;FDA approved;Foundations;Future;Goals;Growth;Guidelines;healing;Health;Health system;improved;Industry;infancy;innovation;Journals;lectures;medical specialties;meetings;Methodology;Mission;mobile application;Modernization;Natural History;Oral;Outcome;Participant;Patients;Persons;Physicians;posters;prevent;Productivity;protocol development;Publications;Research;research and development;Research Personnel;Research Priority;Research Project Grants;Resources;Science;Scientist;skills;skin disorder;social;Standardization;Strategic Planning;Structure;Subgroup;success;symposium;Therapeutic;therapeutic development;Time;tool;training opportunity;Treatment Protocols;United States National Institutes of Health;Update;Vision;Well in self;Work

PROJECT_TITLE: 2024 Pediatric Dermatology Research Alliance (PeDRA) Annual Conference

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


PHR: PROJECT NARRATIVE: Heart disease is the leading cause of death in American adults and presently no therapies exist to promote the replacement of injured cardiac tissue. In contrast, the zebrafish can endogenously regenerate injured or lost cardiac tissue using pre-existing cardiomyocytes in the heart. Through studying the zebrafish I can better understand the gene regulatory features that confer regenerative potential and downstream generate potential routes of regenerative therapies for heart disease in human patients.

PI_NAMEs: HAUGAN, ALEXANDRA K (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Ablation;Adult;American;Amputation;Animal Model;ATAC-seq;Automobile Driving;Biological Assay;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiogenesis;career;Cause of Death;cell motility;Cells;Chick;Cicatrix;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen;Data;Data Analyses;Development;Developmental Process;embryonic stem cell;Excision;experimental study;Fellowship;Fibrin;Future;Gene Expression Regulation;gene regulatory network;Genes;Genetic;genetic manipulation;Goals;Health;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;Human;Impairment;improved;In Situ;in vivo;injured;Injury;interest;Investigation;Knock-out;Label;Learning;Mammals;Measures;Mesoderm;Modeling;Multiomic Data;multiple omics;Mus;Myocardial Infarction;Natural regeneration;nerve injury;Neural Crest;Neural Crest Cell;Outcome;Patients;Population;Process;programs;Proliferating;regeneration potential;regenerative;regenerative therapy;Research Personnel;Role;Route;single cell genomics;single nucleus RNA-sequencing;Stains;stem cell population;Structure;Techniques;Testing;Therapeutic;therapy design;Time;Tissues;transcription factor;transcriptome sequencing;Transgenic Organisms;Ventricular;Work;wound;Zebrafish

PROJECT_TITLE: Uncovering the Role of Neural Crest Gene Regulatory Networks in Cardiac Regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (20)]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: MAYWOOD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Mutations in sarcomere proteins can lead to hypertrophic and dilated cardiomyopathy in humans, and treating these diseases requires us to understand how these mutations alter sarcomere structure and function. To address this gap, we will use high-energy x-ray diffraction, which provides structural details at the molecular level, in live intact beating myocardium in transgenic pig hearts, expressing these various mutations, as pig myocardium is similar to humans.

PI_NAMEs: IRVING, THOMAS C;KIRK, JONATHAN A (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acceleration;Address;Adopted;Adrenergic Agents;Affect;Animal Model;biobank;Biophysics;Calcium;Cardiac;Cardiomyopathies;Chicago;Closure by clamp;connectin;Custom;Data;Diastole;Dilated Cardiomyopathy;Disease;disease-causing mutation;Drosophila genus;Drug Targeting;Exhibits;experimental study;Family suidae;Filament;Goals;Heart;Heart Rate;Human;human model;Hypertrophic Cardiomyopathy;in vivo;induced pluripotent stem cell;inherited cardiomyopathy;insight;instrumentation;Intervention;Knock-in;Knowledge;Liquid substance;Mass Spectrum Analysis;Microfilaments;Modeling;Molecular;Mus;Muscle;mutant;Mutation;Myocardial;Myocardium;Myosin ATPase;Nitrogen;novel therapeutic intervention;Output;Pathogenicity;Pathologic;Pattern;Phase;Phosphorylation;Physiological;porcine model;Post-Translational Protein Processing;Post-Translational Regulation;Primary Myocardial Diseases;Protein Isoforms;Proteins;Proteomics;Quality Control;recruit;Regulation;Relaxation;Research;Resolution;response;Sampling;Sarcomeres;Signal Transduction;Skin;Slice;Stimulus;Stretching;Structure;Synchrotrons;Systole;Techniques;Testing;Therapeutic;Thick Filament;Time;Transgenic Organisms;Troponin;Universities;Variant;X ray diffraction analysis

PROJECT_TITLE: Structural and functional basis of myocardial dysregulation in genetic cardiomyopathy

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Immune cell engagers, including trispecific killer engagers (TriKEs), are an emerging class of anticancer therapeutics that stimulate patient immune cells to kill malignant cells. This project will systematically evaluate the impact of tumor engager scaffold architecture, stability, and expression on TriKE performance within the context of B7-H3, a known cancer marker. This project will continue to advance cancer treatment by elucidating the engineering principles underlying the optimization of TriKEs and other immune cell engagers as well as identify superior B7-H3 TriKEs.

PI_NAMEs: WALSH, MELISSA ARIEL (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Activated Natural Killer Cell;Advanced Development;Advanced Malignant Neoplasm;Affinity;anti-cancer therapeutic;Antibodies;Architecture;Binding;Biological Assay;Bite;cancer biomarkers;cancer cell;Cancer Model;cancer therapy;CD276 gene;cell killing;Cells;cytokine;cytotoxicity;Data;design;Development;dimer;Directed Molecular Evolution;Elements;Engineering;Evaluation;Exhibits;experience;Experimental Neoplasms;FCGR3B gene;Future;Generations;Goals;GP2 gene;Immune;Immune system;immunoengineering;Immunoglobulin Fragments;improved;In Vitro;in vivo;innovation;Interleukin-15;Investigation;Killer Cells;Knowledge;Link;Malignant Neoplasms;Mediating;Molecular;mutant;nanobodies;Natural Killer Cells;neoplastic cell;new therapeutic target;NK Cell Activation;novel;Patients;Peptide Hydrolases;Performance;Phase I Clinical Trials;Physicians;preclinical study;preservation;Process;Production;Proliferating;Property;Proteins;Recombinants;Research;Resistance;response;Safety;scaffold;Scientist;Specificity;stem;Structure;targeted treatment;Technology;Therapeutic;therapeutic protein;Therapeutic Uses;Training;trispecific killer engager;tumor;Tumor Antigens;Tumor Markers;tumor microenvironment;Tumor Promotion;Veins;Work;Yeasts

PROJECT_TITLE: Engineering Immune Engagers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04B-S (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Immunization;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative We will explore the role of anti-parasite antibody in protection of children from the parasitic infection cryptosporidiosis. This work has the promise of identifying immune pathways important for protection from parasitic infections of the gut, and will help with designing a vaccine to prevent this infection estimated to cause, from diarrhea and malnutrition, an overall burden of 12 million disability-adjusted life-years in children.

PI_NAMEs: GILCHRIST, CAROL A;PETRI, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: 2 year old;4 year old;5 year old;acquired immunity;Activities of Daily Living;Acute;Antibiotics;Antibodies;Antibody Response;Antigens;Area;Bangladesh;Bangladeshi;Binding;Biological Assay;Biometry;Birth;CD8-Positive T-Lymphocytes;Cellular Assay;Cellular Immunity;Cessation of life;Child;cohort;Collaborations;Complement;Complex;Cryptosporidiosis;Cryptosporidium;design;Diarrhea;diarrheal disease;disability-adjusted life years;DNA;Enrollment;Environment;extracellular;Fc Receptor;field study;Funding;Generations;Genes;Genetic Polymorphism;Genetic Predisposition to Disease;Genotype;global health;Goals;Helper-Inducer T-Lymphocyte;Household;Human;Human Genetics;Humoral Immunities;Immune;Immune response;Immune Sera;Immunity;Immunoassay;Immunoglobulin A;Individual;Infant;Infection;Infection prevention;Ingestion;innovation;insight;Institution;International;intraepithelial;Knowledge;Learning;Life Cycle Stages;Longitudinal Studies;low and middle-income countries;Malnutrition;Measures;microbiome;neutrophil;NK Cell Activation;Paper;Parasites;Parasitic infection;parasitism;Pathway interactions;Plasma;prevent;Protein Kinase C;Protein Microchips;Proteins;Publishing;Research;Research Personnel;Rest;Role;sample fixation;Small Intestines;Testing;transmission process;Universities;Vaccine Design;Vaccines;Virginia;Visit;Work

PROJECT_TITLE: Field Studies of Cryptosporidiosis in Bangladesh

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Primary Immunodeficiencies;Rare Diseases

PHR: Project Narrative Chondrocyte differentiation is a crucial process during craniofacial development and bone formation. This project will interrogate two histone-modifying enzymes, KMT2C and KMT2D, in this differentiation process to elucidate the mechanism underlying facial dysmorphology characteristic of various craniofacial development disorders. The results of this study will have significant implications for the understanding and treatment of craniofacial and skeletal disease in the context of DNA accessibility.

PI_NAMEs: QUICKSTAD, GABRIELLE ALAIR (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Anterior;Area;Binding;Biological Assay;Bone Development;bone repair;bone scaffold;calcification;Cartilage;Cell Differentiation process;Cells;Cephalic;Characteristics;Chondrocytes;Chromatin;craniofacial;Craniofacial Abnormalities;craniofacial bone;craniofacial development;craniofacial disorder;Defect;Development;Differentiation Antigens;Disease;DNA;Dysmorphology;Enhancers;Enzymes;Epigenetic Process;Epiphysial cartilage;experimental study;Face;face bone structure;Gene Expression;Gene Expression Profiling;Genetic;genetic approach;Genetic Transcription;Genome;Genomic approach;Genomics;Growth;Health;Histologic;Histology;Histone H3;histone methylation;Histones;Human;Hypertrophy;imaging approach;Immunofluorescence Immunologic;Immunohistochemistry;improved;In Vitro;in vivo;Innovative Therapy;Intervention;Kabuki Make-Up Syndrome;Knock-in Mouse;Link;long bone;Lysine;Methodology;Methylation;methylation pattern;Methyltransferase;Modeling;Molecular;morphogens;Morphology;mouse model;Multipotent Stem Cells;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Neural Crest Cell;novel;Osteogenesis;Patients;Phenotype;Physiologic Ossification;Play;Point Mutation;Process;promoter;Proteins;Publications;Regulation;Regulatory Pathway;Role;skeletal;Skeletal Development;skeletal disorder;skull base;stem cells;Structure;Syndrome;Therapeutic;Tissue-Specific Gene Expression

PROJECT_TITLE: Investigating the roles of the H3K4 methyltransferases KMT2C and KMT2D in chondrocyte differentiation and endochondral ossification

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Nanotechnology;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

PHR: Project Narrative Glioblastoma (GBM), a highly aggressive brain tumor, can be treated with gene therapies, however efficacy of these therapeutic molecules is challenged by poor tumoral accumulation. Developing novel, tumor-tropic gene delivery platforms and investigating their cellular transfection profiles may improve therapeutic efficacy and inform therapeutic payloads of these platforms. This proposal will investigate the transfection signatures of a tumor-targeting nanoparticle, SH-BPN, and the use of focused ultrasound to facilitate and enhance its transport to GBM.

PI_NAMEs: DEBSKI, ANNA COLLEEN (contact)

PROJECT_TERMS: Address;angiogenesis;anti-tumor immune response;Antitumor Response;Binding;Biological;Blood;Blood - brain barrier anatomy;blood-brain tumor barrier;Brain;Brain Neoplasms;brain parenchyma;Cell membrane;Cell Physiology;Cell surface;Cells;cellular transduction;Central Nervous System Neoplasms;Characteristics;chemotherapy;Circulation;Clinical Trials;Coupling;delivery vehicle;design;Development;Diagnosis;Dose;Drug resistance;Effectiveness;Elements;Engineering;Ensure;Enzymes;Excision;Exhibits;Extracellular Matrix;Flow Cytometry;Fluorescence;Focused Ultrasound;Focused Ultrasound Therapy;Formulation;Gene Delivery;gene therapy;gene-targeted therapy;Genes;Glioblastoma;Glioma;immunogenicity;improved;In Vitro;in vivo;Injections;Insertional Mutagenesis;Intravenous;intravenous administration;Lead;Ligands;Liver;Location;Measurement;Mechanics;Mediating;Membrane Proteins;Metabolic;Microbubbles;Mus;nanoparticle;nanoparticle delivery;neoplastic cell;non-viral gene delivery;novel;nucleic acid delivery;Nucleic Acids;Oncolytic viruses;overexpression;Oxidative Stress;patient prognosis;Penetration;Permeability;Plasmids;Polyethyleneimine;Primary Brain Neoplasms;Protein Biosynthesis;protein folding;Radiation therapy;Research;Research Personnel;Resected;Reticuloendothelial System;Rodent Model;Route;Site;Specificity;standard of care;study characteristics;success;suicide gene;Sulfhydryl Compounds;targeted treatment;Techniques;Therapeutic;Therapeutic Agents;Time;Tissues;Toxic effect;TP53 gene;Transfection;Translations;Treatment Efficacy;Treatment Protocols;treatment strategy;Tropism;tumor;tumor microenvironment;tumor specificity;Viral Genes;Viral Vector

PROJECT_TITLE: Engineering Focused Ultrasound-Mediated Gene Delivery Platforms for Glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

PHR: PROJECT NARRATIVE Proteins that stabilize and destabilize branched actin networks are thought to be critical for force production by actin networks, but these functions are difficult to isolate. Understanding how actin branches are regulated is critical for understanding cell processes like endocytosis and cell motility. This proposal seeks to understand the role of cortactin-mediated branch stabilization and targeted debranchers in (1) force production and (2) recycling of monomeric actin, as well as (3) elucidating the role and activity of an enigmatic debranching protein, coronin 7.

PI_NAMEs: BILLS, BRODERICK  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: The role of cortactin-mediated actin branch stabilization in force-producing actin networks


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Genetics;Mental Health;Neurosciences;Pain Research;Prevention

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Chronic pain is common, highly morbid, and extremely costly to society; interventions that reduce chronic pain are limited. A lack of effective treatments is partially due to an incomplete understanding of molecular mechanisms driving chronic pain development. The training award proposes to use translational research methods to test hypotheses focused on how DNA methylation levels contribute to biopsychosocial mechanisms leading to chronic post-traumatic pain development.

PI_NAMEs: BRANHAM, ERICA MARIE (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Acute;Acute Pain;Address;Adult;Affect;Automobile Driving;Award;Binding;Bioinformatics;Biological;biological adaptation to stress;Biological Assay;biopsychosocial;career;Cell Culture Techniques;Cell Line;cell type;Chemicals;chromatin immunoprecipitation;Chronic;chronic musculoskeletal pain;chronic pain;cohort;Cohort Analysis;Complex;Corticotropin;cost;CpG dinucleotide;Data;Development;Disease;DNA Methylation;DNA Modification Methylases;DNA Sequence;Dose;effective therapy;Environmental Risk Factor;Epigenetic Process;Event;experience;Exposure to;Foundations;Gene Activation;Gene Expression;gene function;Genes;Genetic Transcription;Glucocorticoids;Health;Hormones;Human;Hydrocortisone;Hypermethylation;hypothalamic-pituitary-adrenal axis;Impairment;Individual;Influentials;Injury;Intervention;Knowledge;Life;Literature;Longitudinal cohort;longitudinal dataset;Longitudinal Studies;Measures;Mediating;Mediation;Mediator;Mentors;Messenger RNA;Methylation;Modeling;Molecular;Morbidity - disease rate;mRNA Expression;Musculoskeletal Pain;Neurons;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Outcome;Pain;Pathogenesis;Patients;Pituitary Gland;Positioning Attribute;post-traumatic stress;prevent;Prevention;Prevention strategy;Pro-Opiomelanocortin;Process;promoter;Promoter Regions;Publishing;Regulation;Reporter;Reporting;Research;Research Design;Research Methodology;response;Risk;Risk Factors;Series;Severities;Site;skills;societal costs;Societies;Statistical Data Interpretation;Stress;Stressful Event;Survivors;System;Testing;Therapeutic;Tissues;Training;transcription factor;Translational Research;Trauma;traumatic stress;Work

PROJECT_TITLE: Stressful life events confer risk for chronic posttraumatic musculoskeletal pain through DNA methylation changes at the POMC promoter

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: Project Narrative As the burden of corneal/ocular surface disease includes more than 4.8 million Americans and 7% of global blindness, a better understanding of the pathologic mechanisms behind the corneal disease development and better treatments are imperative. The objective of this small multidisciplinary conference, focused on the cornea and ocular surface, is to provide a venue for clinicians, scientists, and trainees in the field to come together for discussions of current work, and to forge new collaborations aimed at elucidating the mechanisms that underlie the development of dry eyes, microbial eye diseases, immune graft rejection, and endothelial dysfunction; thus, identifying the means to treat, cure, and prevent corneal blindness. Achieving these goals will not only further the quality of life for our aging population but will, in the long term, reduce the burden on society from these blinding conditions.

PI_NAMEs: JURKUNAS, ULA V. (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acceleration;age group;aging population;American;Anterior;Asia;Award;Basic Science;Blindness;Charge;Clinical Research;Collaborations;Cornea;Corneal Diseases;design;Development;Diagnosis;Disease;Doctor of Philosophy;Electronic Mail;endothelial dysfunction;Endothelium;Environment;Europe;European;Eye Banks;Eye diseases;eye dryness;Face;Failure;Feedback;forging;Fostering;Foundations;Fuchs' Endothelial Dystrophy;Functional disorder;Funding;Future;Goals;graduate student;Graft Rejection;Immune;Immunologics;improved;innovation;insight;International;Keratitis;Laboratory Research;lectures;Location;medical schools;meetings;member;Methods;microbial;mid-career faculty;multidisciplinary;Names;new technology;next generation;ocular surface;ocular surface disease;Ophthalmology;Oral;Pathogenesis;Pathologic;Physicians;Portugal;posters;prevent;professor;programs;Quality of life;Recording of previous events;regenerative therapy;Reporting;Research;Research Personnel;Science;Scientist;Senior Scientist;skills;Societies;success;Surveys;symposium;Time;translational applications;Transplantation;Travel;Vision;Visual impairment;Work

PROJECT_TITLE: 33rd Biennial Cornea Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (12)]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC

PHR: PROJECT NARRATIVE Overall, these studies will provide a better understanding of the relationship between metabolism and cellular heterogeneity in Treg cells under homeostasis and in the TME, as well as deliver insight into the functional roles of autophagy- and endosome-associated complexes in Treg cells in different immunological contexts. Identifying mechanisms that impact Treg cell activation and suppressive function and can be targeted to overcome adverse autoimmune or inflammatory disease outcomes or unleash anti-tumor immunity may manifest in new therapeutic options for these diseases.

PI_NAMEs: NORTON, ERIENNE GRACE (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute;Address;Age Months;Antitumor Response;Autoimmune Diseases;Autoimmunity;Autophagocytosis;autoreactive T cell;Biological;Catalytic Domain;Cell Differentiation process;Cell Lineage;Cell Maintenance;Cell Physiology;Cells;Cellular biology;Complex;Data;Disease;Disease Outcome;Endosomes;fitness;Flow Cytometry;functional adaptation;Gene Deletion;Generations;Genes;Genetic;Genetic Models;Genetic Transcription;Heterogeneity;Homeostasis;Immune;Immune system;Immune Tolerance;Immunologics;Immunosuppression;Impairment;improved;In Vitro;in vivo;Inflammatory;innovation;Innovative Therapy;insight;interest;longitudinal analysis;Lymphoproliferative Disorders;Maintenance;Malignant Neoplasms;Mediating;Metabolic;metabolic fitness;Metabolism;mevalonate;Mitochondria;Modeling;Molecular;mouse genetics;Multiprotein Complexes;Mus;neoplasm immunotherapy;novel;novel therapeutics;Nutrient;Oxidation-Reduction;Pathway interactions;Phenotype;Play;Population;Process;Regulatory T-Lymphocyte;response;Role;Shapes;Signal Transduction;Systems Biology;Techniques;Testing;Therapeutic;Tissues;trafficking;transcriptomics;translational potential;tumor;Tumor Immunity;tumor microenvironment;tumorigenesis;Vps34 Phosphatidylinositol 3 Kinase

PROJECT_TITLE: Metabolic signaling dictates context-dependent Treg cell functional heterogeneity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]