NIH_SPENDING_CATS: Aging;Arthritis;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Chronic Pain;Clinical Research;Neurosciences;Nutrition;Pain Research;Physical Activity

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: We examine the contribution of dopaminergic neurotransmission, dopaminergic networks' activity, and brain energy metabolism, to physical performance fatigability in older adults. We propose these neuro-energetic markers, individually and in combination, may explain fatigability beyond what is predicted by skeletal muscle energetics and cardiopulmonary function.

PI_NAMEs: ROSANO, CATERINA  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Accounting;Address;Adult;Affect;age related;Aging;Arthritis;Attention;Behavior Therapy;Behavioral;Biopsy;Blood flow;Body mass index;Brain;brain magnetic resonance imaging;Cardiopulmonary;cardiopulmonary system;Central Nervous System;Cerebrum;clinically relevant;Communities;comorbidity;Complex;Corpus striatum structure;cost;cost effective;Data;Dementia;Deterioration;Disabling;Disease;Dopamine;Energy Metabolism;Equipment;executive function;Exercise Test;Exertion;Fatigue;Feeling;fitness;frailty;functional near infrared spectroscopy;Funding;Gait speed;Heart Rate;human old age (65+);Image;Impairment;improved;Individual;innovation;Intervention;Knowledge;Lactic acid;Magnetic Resonance Imaging;Measures;metabolic rate;Metabolism;Modeling;mortality;Motivation;multidisciplinary;Muscle;Muscle Fatigue;muscle form;Muscle Mitochondria;muscle strength;muscular system;Myalgia;neural;neural network;neuroimaging;Neurologic;neurotransmission;novel;older adult;Older Population;Outcome;Oxygen;Pain;Participant;Patients;Performance;pharmacologic;Physical activity;Physical Performance;Physiological;Population;Positron-Emission Tomography;Prefrontal Cortex;Process;Protocols documentation;Psyche structure;Recommendation;Rehabilitation therapy;Research;Rest;Role;Shortness of Breath;Signal Transduction;Skeletal Muscle;Sleep;Spectrum Analysis;Standardization;strength training;symposium;System;Testing;Translating;treadmill;Urine;Variant;Visit;Walking;Weight-Bearing state;Work;young adult

PROJECT_TITLE: Neural and Energetic Drivers of Performance and Perceived Fatigability in Older Adults


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Aging is associated with increased risk of slow and/or incomplete healing of a bone injury. The reasons why are incompletely understood, and there are presently no treatments that directly address this problem. This project focuses on modulating the mechanical stimuli present at the injury site, identifying the effects of these changes on bone tissue formation by young and aged cells, and using this knowledge to determine ways of overcoming the aging-associated deficits in bone healing.

PI_NAMEs: MORGAN, ELISE F (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;Age;age related;age related changes;age-related disease;aged;Aging;aging related;analytical tool;animal old age;Animals;Architecture;Area;Bioreactors;bone;bone cell;bone healing;Bone Injury;Bone Matrix;Bone Regeneration;bone repair;bone strength;bone toughness;cell age;cell behavior;Cell Differentiation process;Cell Proliferation;Cells;Ceramics;Characteristics;Clinical;Clinical Data;Cues;Data;Data Element;Defect;design;digital;Elements;Fluorescence;Foundations;Gait;Gene Expression;Generations;healing;Heterogeneity;Histology;Immunohistochemistry;Impairment;Implant;In Vitro;in vivo;Individual;Injury;innovation;Knowledge;Laboratory Study;leptin receptor;Light;Liquid substance;manufacture;Marrow;mechanical load;mechanical signal;Mechanical Stimulation;mechanical stimulus;Mechanics;Methods;microCT;mineralization;Modeling;Monitor;Mus;novel;old mice;osteoblast differentiation;Osteoblasts;Osteogenesis;osteogenic;Outcome;pathological aging;Porosity;pressure;Printing;Proliferating;protein expression;recruit;Regenerative response;Research Personnel;response;restoration;Risk;Risk Factors;Role;scaffold;shear stress;Site;skeletal injury;skeletal stem cell;Stimulus;Stromal Cell-Derived Factor 1;Stromal Cells;success;Techniques;Technology;Testing;tibia;time use;transcriptome sequencing;transcriptomics;Vascularization;Work

PROJECT_TITLE: Tailoring of cellular mechanical microenvironments to rescue age-related impairments in bone regeneration

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Data Science

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Project Narrative To advance scientific discoveries toward improved human health and societal well-being, the Scripps Research K12 Scholars Program will educate and train early-career researchers in the newest translational methods for evaluating promising findings in preclinical studies, clinical trials, and community-engaged implementation. Using our Translational Institute’s strengths of genomics, digital medicine, informatics, and community engagement, with new initiatives in data science and population health, our program will mentor the methods that accelerate new innovations across the translational spectrum to increase access for all people. Our program will expand the biomedical researcher workforce with graduates experienced in cross-disciplinary teamwork, inter-institutional public-private partnerships, open communication, inclusive research standards, and resource-sharing approaches – skills and characteristics that drive investigational breakthroughs toward greater public health.

PI_NAMEs: NICHOLSON, LAURA  (contact);PHILIS-TSIMIKAS, ATHENA

PROGRAM_OFFICER_NAME: CHANG, SOJU

PROJECT_TERMS: advanced analytics;biobank;Biomedical Research;Biotechnology;California;career;career development;Characteristics;Child;Clinical;Clinical Research;Clinical Trials;Collaborations;Collection;Communication;community advisory board;community engagement;Community Health;Competence;Consultations;Data;Data Analytics;Data Science;design;Development;digital health;early-career faculty;Education;Educational Curriculum;Electronic Health Record;Enrollment;equity, diversity, and inclusion;Ethics;Faculty;Genomic medicine;Genomics;Government Agencies;Grant;Health;Individual;Institution;Instruction;inter-institutional;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methodology;Outcome;Physicians;population health;Precision Health;Privatization;programs;Public Health;Public Health Schools;recruit;Reproducibility;Research;Research Activity;Research Design;Research Institute;Research Personnel;Science;Scientist;Services;Site;Social Environment;Structure;Students;Training;Translational Research;translational scientist;Underrepresented Populations;United States;Universities;Woman

PROJECT_TITLE: CTSA K12 Program at The Scripps Research Institute


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Osteoporosis;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE  These investigations will clarify the mechanisms responsible for Hajdu Cheney Syndrome, a rare but devastating disease characterized by craniofacial manifestations, lysis of the distal phalanges and bone loss with fractures. The proposed work will serve to establish the function of an important Notch target gene that is responsible for the manifestations of the syndrome. In addition, the work proposed will target the mutation in models of human disease, as a means to treat and cure a rare but devastating clinical disorder. The work will form the basis for treating other genetic disorders affecting the skeleton.

PI_NAMEs: CANALIS, ERNESTO  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Acro-Osteolysis;Affect;Alleles;Antisense Oligonucleotides;Antisense Technology;Behavior;bone;bone loss;Bone remodeling;Bone Resorption;Cell Differentiation process;Cell Line;Cells;Clinical;craniofacial;Cytolysis;Dependence;Development;Disease;disease model;Distal;Effectiveness;Enhancers;ES01;Event;Exhibits;Exons;Fracture;gain of function;Gene Modified;Genes;Genetic Diseases;Goals;Hajdu-Cheney Syndrome;Heterozygote;Human;human disease;human induced pluripotent stem cells;human model;In Vitro;in vivo;induced pluripotent stem cell;Intervention;Investigation;Knowledge;Lead;Ligands;Modeling;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Myelogenous;NF-kappa B;notch protein;novel;novel therapeutic intervention;Nuclear;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteopenia;Other Genetics;overexpression;Phalanx;Phenotype;Play;Positioning Attribute;premature;prevent;Proteins;receptor expression;Regulation;Research;Role;Secondary to;skeletal;skeletal disorder;Skeleton;Syndrome;Testing;Therapeutic Intervention;tomography;TRANCE protein;Ubiquitination;Work

PROJECT_TITLE: Mechanisms and Treatment of Hajdu Cheney Syndrome

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Kidney Disease;Transplantation

ORG_CITY: BIRMINGHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative BK polyomavirus reactivation in kidney transplant patients results in graft loss for 10% of patients. The goal of this project is to apply our understanding of host pathways that are required by BKPyV for viral production in human primary kidney cells to determine if these can be exploited as antiviral targets. Identification of effective BKPyV antivirals the potential to treat this devastating viral reactivation without reducing immunosuppression in kidney transplant patients, which increases the risk of graft loss.

PI_NAMEs: THOMPSON, SUNNIE R (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Acute;Affect;Aftercare;Allografting;Anti-viral Agents;ataxia telangiectasia mutated protein;ATR gene;BK Virus;Bladder;Bone Marrow Transplantation;Bortezomib;Cell Cycle;Cell Cycle Arrest;Cell Cycle Regulation;Cell Nucleus;Cell Survival;cell type;Cells;Childhood;Clinical;Clinical Research;Clinical Trials;clinically relevant;Cystitis;Data;DNA Damage;DNA Viruses;Dose;Drug toxicity;early phase clinical trial;Epithelial Cells;experience;Failure;FDA approved;fitness;Foundations;Generations;Goals;Graft Rejection;Hemorrhage;Human;Immune system;immunosuppressed;Immunosuppression;Infection;inhibitor;Injury;Kidney;kidney cell;Kidney Diseases;Kidney Transplantation;Large T Antigen;Mitosis;Monitor;Morbidity - disease rate;mortality;multicatalytic endopeptidase complex;Nonstructural Protein;Oral;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Phosphotransferases;Plasma;Polyomavirus;Polyomavirus Infections;Polyploid Cells;Population;prevent;Probability;Production;Productivity;Proteasome Inhibition;Proteasome Inhibitor;protein degradation;response;Risk;S phase;Small T Antigen;Stem cell transplant;Structural Protein;Symptoms;Testing;Toxic effect;transcriptome sequencing;transcriptomics;Transplant Recipients;Tubular formation;Urine;Viral;viral DNA;Viral Genome;Viremia;Virus;Virus Assembly;Virus Replication;Virus Shedding

PROJECT_TITLE: Antiviral treatment of BK polyomavirus reactivation


NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Wound Healing and Care

ORG_CITY: TUCSON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative Advanced age is associated with increased incidence of pressure ulcers. Our preliminary data suggests that hypoxia-inducible factor 1-alpha (HIF-1α) is dysregulated with aging, and that stabilization of HIF-1α using an FDA approved molecule (deferoxamine, DFO) heals pressure ulcers in small animal models. Here we will confirm aberrant HIF-1α signaling in aged skin and pressure ulcer biopsy specimen from human patients, and test transdermal delivery of DFO (DFO-TDDS) to treat pressure ulcers using a human-like porcine pressure ulcer model.

PI_NAMEs: GURTNER, GEOFFREY C (contact)

PROGRAM_OFFICER_NAME: KATIYAR, PRAGATI

PROJECT_TERMS: 5 year old;Acceleration;Affect;age related;Age Years;age-related disease;aged;Aging;aging population;American;Animal Model;Animals;Back;Biopsy Specimen;Buttocks;Cells;chronic wound;comorbidity;Data;Debridement;decubitus ulcer;Defect;Deferoxamine;Dermis;Diabetes Mellitus;Drug Delivery Systems;effectiveness validation;efficacy testing;Elderly;Family suidae;FDA approved;Fibroblasts;Functional disorder;Gene Targeting;healing;Health Care Costs;Healthcare Systems;Hip region structure;Human;human old age (65+);hydrophilicity;Hypoxia;hypoxia inducible factor 1;Immobilization;Impaired wound healing;Impairment;improved;Incidence;Individual;Intervention;Lead;Mobility decline;Modeling;Molecular;Mus;neovascularization;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Nursing Homes;old mice;older patient;Operative Surgical Procedures;pathological aging;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;porcine model;preclinical study;pressure;prevent;Prevention;Protein Analysis;Proteins;Research;Risk;Safety;Sampling;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Skin;Skin Aging;Skin Tissue;skin ulcer;small molecule;Specialist;standard of care;Stereotyping;Stratum corneum;System;Testing;Time;Tissues;transcriptomics;Transdermal substance administration;Ulcer;United States;United States National Institutes of Health;Vascular Diseases;Work;wound;wound healing

PROJECT_TITLE: TARGETING HIF-1α DYSFUNCTION TO TREAT PRESSURE ULCERS IN THE AGED

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative There is an increase in cardiovascular disease with age, stemming from the fact that as blood vessels age, they become more calcified and stiff. Over time, these changes impair critical organ function (e.g. brain, heart, and kidneys). The aim of this research is to understand how proteins called ectonucleotidases, which reduce inflammation and the tendency for clot formation, influence how blood vessels age. Gaining this knowledge will hone future strategies to treat vascular disease.

PI_NAMEs: SUTTON, NADIA RAZAQ (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Achievement;Adenosine;ADP Receptors;Age;age acceleration;age related;age related decline;Age Years;aged;Aging;Aorta;Arteries;Atherosclerosis;ATP Receptors;Biological Process;Biology;Blood Vessels;Brain;calcification;Calcium;Cardiac;Cardiovascular Diseases;Cardiovascular system;Cell surface;Cells;Clinical;Coagulation Process;Collagen;Coronary artery;coronary artery calcification;Cues;Data;demographics;Deposition;Development;Disease;ecto-nucleotidase;Elasticity;Elastin;Endothelial Cells;Environment;Enzymes;experimental study;Exposure to;extracellular;Extracellular Matrix;Fibrosis;Foundations;Future;Gene Expression;healthcare burden;Heart;Human;human old age (65+);human tissue;Impairment;indexing;Inflammation;Inflammatory;inflammatory marker;insight;Kidney;Knowledge;Leukocytes;Life;life span;Mediating;Metabolic;middle age;mouse model;Mus;Older Population;Organ;Osteogenesis;osteogenic;paracrine;Pathologic;Patients;Phenotype;Physiologic Ossification;Physiologic pulse;Physiological;Population;Predisposition;prevent;Process;Production;Proteins;Proteomics;Pulse Pressure;Purinergic P1 Receptors;radiological imaging;Research;Research Personnel;Risk Factors;Role;Signal Transduction;Smooth Muscle Myocytes;stem;Stress;Stress Tests;Surface;Testing;Time;transcription factor;transmission process;Vascular calcification;Vascular Diseases;Vascular Smooth Muscle

PROJECT_TITLE: Ectonucleotidase modulation of age-dependent vascular calcification and stiffness


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Lymphatic Research;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSCIENCES

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE Apolipoprotein E4 (APOE4), the greatest genetic risk factor for Alzheimer's disease (AD), confers a pro- inflammatory state in the normal aging and AD brain parenchyma, but its functions in brain border immunity are still unknown. Here we propose to apply single-cell multi-omics profiling of ex vivo human border cells and in vitro border cell modeling to investigate APOE4's effect on border cell states and function in normal aging and AD.

PI_NAMEs: WANG, YANLING  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: abeta deposition;Aging;aging brain;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapeutic;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Autopsy;Brain;brain parenchyma;Cell Communication;Cell model;cell type;Cells;Chromatin;combat;computational suite;Computer Analysis;computerized tools;disease phenotype;Drainage procedure;drug candidate;Dura Mater;Exhibits;experience;functional decline;Functional disorder;genetic risk factor;Goals;Human;Image;Immune;Immunity;Immunoassay;Impairment;In Vitro;Individual;induced pluripotent stem cell;Inflammation Mediators;Inflammatory;Innate Immune Response;insight;intercellular communication;Literature;Lymphatic function;Lymphatic System;lymphatic vessel;macromolecule;Macrophage;Maps;Meningeal lymphatic system;Meninges;Microglia;Modeling;Molecular;Morphology;Multiomic Data;multiple omics;Mus;Neurodegenerative Disorders;neuroinflammation;normal aging;novel;Organoids;Other Genetics;Phenotype;Play;premature;Research;Role;single-cell RNA sequencing;Specificity;Structure of choroid plexus;System;Testing;Therapeutic Intervention;therapeutic target;three-dimensional modeling;transcriptome;transcriptomics

PROJECT_TITLE: Investigating the Effect of APOE Alleles on Neuro-Immunity of Human Brain Borders in Normal Aging and Alzheimer's Disease Using Single-Cell Multi-Omics and In Vitro Organoids


NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Estrogen;Genetics;Human Genome;Women's Health Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE The overall goal of this project is to determine the role of cellular senescence and epigenetic modifications in primordial follicle exhaustion, and thus ovarian failure. We will study the emergence of these age-related hallmarks in a cell-type specific manner at different time points throughout the reproductive lifespan of mice; which will allow us to determine the chronological order in which these changes occur in different cells in the ovary. We will also determine if the removal of senescent-like cells and/or their inflammatory phenotype will extend reproductive lifespan, which is currently the overall goal of reproductive research throughout the world.

PI_NAMEs: STOUT, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: WANG, FEI

PROJECT_TERMS: Acceleration;Age;Age Months;age related;age related changes;Age Years;Aging;aging process;Alleles;Animal Model;Attenuated;Biochemical;Body System;burden of chronic illness;Caloric Restriction;Cell Aging;cell injury;Cell Separation;cell type;Cells;Chromatin;Chronology;Clinical;Data;Development;DNA;DNA Damage;DNA Methylation;Dwarfism;Elderly;Embryo;Emerging Technologies;Encapsulated;Endocrine;Enhancers;Enterobacteria phage P1 Cre recombinase;epigenetic clock;Epigenetic Process;epigenomics;Excision;exhaustion;Female;functional decline;Gene Expression;Gene Expression Profile;Genetic;genetic manipulation;Genome;Genomics;Germ Cells;Goals;granulosa cell;Growth;hallmarks of aging;Health Benefit;healthspan;Histologic;Human;in vivo;Infiltration;Inflammation Mediators;Inflammatory;Intervention;Knowledge;Laboratories;life span;Link;Longevity;Macrophage;Modeling;Modification;Molecular;Mus;nonhuman primate;novel;Nucleic Acids;old mice;Oocytes;Ovarian;Ovarian aging;ovarian dysfunction;ovarian failure;Ovarian Granulosa Cell;Ovariectomy;Ovary;Ovulation;Pattern;Perimenopause;pharmacologic;Pharmacotherapy;Phenotype;Play;Population;Pregnancy;preservation;prevent;Primordial Follicle;Production;pup;Reporting;reproductive;reproductive fitness;reproductive senescence;Research;Resources;RNA;Role;Scientific Advances and Accomplishments;searchable database;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Sirolimus;Source;Stress;Testing;theca cell;Time;timeline;Tissues;Transcript;transcription factor;transcriptomics;Transgenic Organisms;Work

PROJECT_TITLE: Cellular senescence and epigenomic remodeling in ovarian aging


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative For both SARS-CoV-2 and influenza the difficulty of inducing long-lasting immunity that can protect against evolving viruses continues to complicate vaccine design. My proposed research will provide a functional assay to evaluate seasonal CoV immunity, characterize of the diversity of influenza mutations after a controlled human infection, and develop a protocol for a seasonal CoV controlled human infection model. These tools are necessary to advance the development of a controlled human infection model with the seasonal CoV OC43, which will provide an efficient mechanism to evaluate broadly protective CoV countermeasures.

PI_NAMEs: DEMING, MEAGAN ELISE (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Adult;Advanced Development;Affect;Antibodies;assay development;Assessment tool;betacoronavirus;Binding;Bioinformatics;Biological Assay;Biological Models;career;Cell Culture Techniques;Clinical;Clinical Protocols;Complex;Coronavirus;Coronavirus Infections;coronavirus therapeutics;coronavirus vaccine;cross-species transmission;cytokine;design;Development;Dose;Elements;Ensure;Epitopes;Ethics;Evolution;Exclusion Criteria;follow-up;Foundations;Future;future outbreak;genome analysis;Genotype;Glycoproteins;Goals;Growth;Human;human coronavirus;Humoral Immunities;Immune response;Immunity;Immunologic Memory;Immunologics;Immunology;inclusion criteria;Individual;Infection;Influenza;influenza infection;influenzavirus;Innate Immune Response;Integration Host Factors;Intervention;Leadership;Learning;Maryland;Mediator;Mentors;Mentorship;Modeling;Mutation;Nature;next generation sequencing;novel;novel coronavirus;outbreak preparedness;outbreak response;Participant;Pathogenicity;Population;Predisposition;Preparation;pressure;Process;Productivity;protocol development;Protocols documentation;Readiness;Research;Research Design;Research Personnel;Residual state;Resources;respiratory;RNA Viruses;Role;Safety;Sampling;SARS-CoV-2 immunity;SARS-CoV-2 variant;screening;seasonal coronavirus;Seasons;skills;Specificity;Specimen;System;therapeutic development;Time;tool;Training;Uncertainty;universal coronavirus vaccine;Universities;Vaccine Design;vaccine development;vaccine efficacy;vaccinology;Validation;Variant;Viral;Viral Genome;Viral Pathogenesis;Viral Respiratory Tract Infection;virology;Virus;Virus Replication;Virus Shedding

PROJECT_TITLE: Characterization of seasonal CoV immunity and operationalization of a novel controlled human infection model for the betacoronavirus OC43

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Mental Health;Pain Research

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative (3 sentences) Chronic pain is a critical public health problem that affects over 100 million people in the United States and is the leading cause of years lived with disability. Yet, most common chronic pain treatments fail to significantly and reliably relieve pain and improve physical and psychological functioning for many people. Thus, the proposed project will develop and test a novel multicomponent breathwork intervention in people with chronic low back pain, which will inform future work investigating whether this intervention is an effective treatment for chronic pain that also has the potential to improve emotional well-being and whole person health.

PI_NAMEs: PRATSCHER, STEVEN D (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adherence;Affect;Affective;Anger;Anxiety;arm;Award;Awareness;biological systems;biopsychosocial;biopsychosocial factor;Breathing;career development;Chronic low back pain;chronic pain;chronic pain management;Clinical;clinical pain;Clinical Research;comparison intervention;Competence;Conduct Clinical Trials;Conscious;cost;Data;design;Development Plans;Direct Costs;Disabling;effective therapy;efficacy testing;Emotional;emotional distress;Emotions;Environment;Esthesia;Evaluation;evidence base;experience;Facilities and Administrative Costs;feasibility trial;Feedback;Florida;Foundations;Funding;Future;Goals;Human;improved;Individual;Injections;innovation;Integrative Therapy;Interoception;Intervention;Interview;K-Series Research Career Programs;Knowledge;Manuals;Mental Depression;Mentored Research Scientist Development Award;Mentors;Mentorship;Mind-Body Intervention;mindfulness;Mindfulness Training;Modeling;Modification;multi-component intervention;National Center for Complementary and Integrative Health;novel;Operative Surgical Procedures;Opioid;Pain;Pain management;pain outcome;pain relief;Pain Research;Participant;Patients;Persistent pain;Persons;Physiological;Physiological Processes;Physiology;pilot test;Population;Positioning Attribute;Preparation;Principal Investigator;Process;Productivity;programs;Protocols documentation;psychologic;Psychosocial Factor;Public Health;Qualifying;randomized controlled design;Randomized, Controlled Trials;Recommendation;recruit;Regulation;Relaxation;Reproducibility;Research;research and development;Research Personnel;Respiration;respiratory;satisfaction;Scientist;Sensory;Source;Stress;Stressful Event;symposium;Techniques;Testing;Therapeutic;therapy development;Training;Training Activity;Trauma;treatment as usual;Treatment Factor;trial comparing;trial design;United States;United States National Institutes of Health;Universities;vagus nerve stimulation;Well in self;whole health;Work;Writing;years lived with disability

PROJECT_TITLE: Developing and testing a multicomponent breathwork intervention for people with chronic pain


NIH_SPENDING_CATS: Aging;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Merkel cells constitute a rare population of skin cells that are specialized to perceive gentle touch responses. As we age, our skin gradually loses Merkel cells and its sense of touch and this deficit is a major factor for determining quality of life and the ability to live independently for the elderly; however, the cellular and genetic factors responsible for age-related loss of Merkel cells are largely unknown. If proven, our application will unlock how stem cells in our skin maintain the Merkel cell lineage.

PI_NAMEs: OWENS, DAVID MICHAEL (contact)

PROJECT_TERMS: Address;Adult;Age;Age Months;age related;age related decline;Age Years;aged;Aging;Alleles;Apoptosis;Behavior;Cell Count;Cell Lineage;Cell Maintenance;Cell Survival;Cells;Cellular biology;Communication;Cutaneous;Data;Defect;Development;Eating;Elderly;epithelial stem cell;Epithelium;ERBB2 gene;Etiology;Exclusion;falls;Focal Adhesions;Frequencies;Future;Genetic;genetic approach;Germ Lines;Goals;grasp;Hand;Homeostasis;Human;In Vitro;in vivo;keratinocyte;Label;Laboratories;Ligands;Maintenance;Mammals;Measures;Mechanoreceptors;Mediator;Merkel Cells;Messenger RNA;Molecular;Morphogenesis;Morphology;mouse model;Mus;mutant;nerve supply;old mice;Organ;Pathway interactions;Physiologic pulse;Physiological;Population;postnatal;Posture;progenitor;Proliferating;Property;Proteins;Proteomics;Quality of life;receptor;Regulation;Reporter Genes;Research Design;response;Rodent;Role;senescence;Sensory;Signal Pathway;Signal Transduction;Skin;somatosensory;sound;Source;stem cell function;stem cells;Structure;Tactile;Tamoxifen;Testing;Texture;tool;Touch sensation;transcriptome;Transgenic Mice;Transgenic Organisms;translational study;Utrophin;vibration

PROJECT_TITLE: Investigating the role for Utrophin in age-related decline of the Merkel lineage


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Nanotechnology;Women's Health Research

ORG_DEPT: NEUROSURGERY

PHR: Project Narrative Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer and management of this cancer is challenging because it does not respond well to most of the FDA-approved breast cancer drugs. The goal of this study is to develop targeted, tumor-penetrating nanoparticles to more effectively deliver chemotherapeutics to TNBC tumors and metastases. The proposed studies may in the long term have high clinical impact with respect to our current treatment options for TNBC patients.

PI_NAMEs: KIM, ANTHONY J. (contact)

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: ABCB1 gene;Abraxane;Address;Affinity;aggressive breast cancer;Antineoplastic Agents;Applications Grants;Binding;Biodistribution;Blood Circulation Time;Brain;Breast Cancer Cell;Breast Cancer Patient;cancer type;Cell Surface Receptors;chemotherapy;Clinical;Couples;cytotoxicity;Data;Development;Diameter;Doxorubicin;Drug Combinations;Drug Delivery Systems;drug distribution;Drug Formulations;Drug Kinetics;drug resistance development;Drug usage;effective therapy;Engineering;Epidermal Growth Factor Receptor;Equilibrium;Estrogen Receptors;Exhibits;Extracellular Matrix;Extravasation;FDA approved;Fibroblast Growth Factor;Formulation;Future;Goals;hormone therapy;Human;improved;In Vitro;in vivo;innovation;insight;Knowledge;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;MDA MB 231;member;Methods;Modeling;molecular drug target;Multi-Drug Resistance;Mus;nanoparticle;nanoparticle drug;nanopolymer;Neoplasm Metastasis;neoplastic cell;novel;orthotopic breast cancer;Ovarian;Paclitaxel;particle;Particle Size;Patient-derived xenograft models of breast cancer;Patients;Penetration;Pharmaceutical Preparations;Polyethylene Glycols;Primary Neoplasm;Progesterone Receptors;Prostate;Pump;receptor internalization;Role;surface coating;Surface Plasmon Resonance;targeted agent;Testing;Therapeutic;therapeutic nanoparticles;Tissues;Toxic effect;trafficking;Translating;Treatment Efficacy;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;Tumor Necrosis Factor Receptor;Tumor Tissue;tumor xenograft;uptake;Vertebral column;Work;Xenograft procedure

PROJECT_TITLE: Impact of Fn14-targeted Nanoparticles for Triple-Negative Breast Cancer

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Endocrine Disruptors;Immunization;Infectious Diseases;Lung;Pediatric;Prevention;Vaccine Related

ORG_CITY: ROCHESTER

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Public Health Relevance This project addresses an issue of direct public health relevance, the findings of which will be broadly applicable to populations around the world. Altered immune function, leading to decreased vaccine responses or increased respiratory infection, is a serious global public health concern. This project will advance our understanding of how ubiquitous environmental exposures, such as polychlorinated biphenyls, affect these outcomes, moving us closer to effective primary prevention strategies to further reduce the burden of infectious disease.

PI_NAMEs: JUSKO, TODD  (contact);LAWRENCE, B PAIGE

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: 16 year old;Activities of Daily Living;Acute bronchitis;Address;Adolescence;Adolescent;Affect;Age;Age Months;age related;Antibodies;Antibody Response;Antibody-mediated protection;B-Lymphocytes;Bacille Calmette-Guerin vaccination;BCG Live;BCG Vaccine;bioaccumulation;Biological Response Modifiers;Birth;Categories;Cells;Chemicals;Child;Childhood;Clinical;cohort;Collection;Communicable Diseases;Data;Developed Countries;Development;Developmental Process;Diagnosis;early childhood;early life exposure;emerging adult;Environment;environmental agent;Environmental Exposure;Exogenous Factors;exposed human population;Exposure to;fighting;Flow Cytometry;follow-up;Food Chain;Frequencies;Future;Health;Human;Immune;immune function;Immune system;immune system function;Immunity;Immunoglobulin A;Immunoglobulin G;Immunologic Markers;Immunosuppression;immunotoxicity;in utero;Individual;infancy;Infant;Infection;innovation;Invaded;Knowledge;Life;Lower Respiratory Tract Infection;Lymphocyte;Lymphocyte Subtypings;Measurement;Measures;Memory;Memory B-Lymphocyte;Methods;Mycobacterium bovis;Nose;Outcome;pathogen;Peripheral;pharmacokinetic model;Pharyngeal structure;Phase;Physicians;physiologically based pharmacokinetics;pollutant;Polychlorinated Biphenyls;Population;postnatal;Predisposition;prenatal;prenatal exposure;Prevention strategy;Primary Prevention;Process;Public Health;public health relevance;Research;respiratory morbidity;respiratory pathogen;Respiratory Tract Infections;response;Serum;Shapes;Slovakia;T cell response;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Th1 Cells;Thymus Gland;Time;Tissues;Umbilical Cord Blood;Vaccination;vaccine efficacy;vaccine response;Vaccines;Work

PROJECT_TITLE: Human Immunotoxicity of Developmental PCB Exposure

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: SEASIDE

ORG_NAME: CALIFORNIA STATE UNIV,  MONTEREY BAY

PHR: Project Narrative:  Although more Latinx are going to college, <10% earn degrees in the sciences. Improved STEM skill-sets that include environmental health literacy can help students learn how to solve environmental challenges and enter an expanding science-based labor sector. With the Monterey Bay Aquarium, CHAMACOS, community art partners, and the Monterey County Office of Education, we aim to improve local environmental health literacy in schools serving predominantly Latinx youth in the low-income agricultural Salinas Valley. We will integrate environmental health literacy into NGSS-aligned teacher training programs addressing ocean plastics, climate change, and agriculture; develop student-driven action projects infused with the arts and research experiments; evaluate the impacts of these training programs on student knowledge; and work with youth to develop art productions to bring environmental health literacy education to wider audiences.

PI_NAMEs: SLOWN, CORIN  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Affect;Age;agricultural community;Agriculture;Air Pollution;aquarium;Area;artist;Arts;aspirate;Awareness;Back;California;career;Case Study;Censuses;Child;climate change;Collaborations;college;Communication;Communities;community based participatory research;Community Health;Community Health Education;Competence;contaminated water;County;Ecosystem;Education;Educational Curriculum;Educational process of instructing;efficacy evaluation;eleventh grade;Engineering;Environment;Environmental Health;Environmental Impact;experience;experimental study;Exposure to;Face;Family;farm worker;Fertilizers;gang;Goals;Health;Health education;health literacy;high school;High School Faculty;High School Student;Hispanic Populations;Hispanic-serving Institution;Housing;Human;improved;Individual;junior high school;Knowledge;land use;Language;Latinx;Leadership;Learning;literacy;Low income;marine;Mathematics;Methods;Mexican Americans;Middle School Faculty;Modeling;Multimedia;Music;Next Generation Science Standards;Nitrates;Oceans;Pacific Ocean;Pesticides;Plastics;Policy Maker;pollutant;Pollution;Population;Positioning Attribute;Price;Printing;Process;Production;programs;project-based learning;Recording of previous events;Reporting;Research;Research Project Grants;Resources;Role;Safety;Salinas Valley;school district;Schools;Science;science education;science teacher;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Scientist;Self Efficacy;skills;STEM curriculum;Students;summer internship;symposium;teacher;Teacher Professional Development;Training and Education;Training Programs;Translations;Universities;Violence;Visual;Work;Youth

PROJECT_TITLE: Science teaching through the arts:  Bringing state-of-the-art environmental health education to youth in agricultural communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Endocrine disorders such as diabetes, obesity, dyslipidemias, thyroid disease and polycystic ovarian syndrome are all associated with enormous costs; both with respect to their morbidity and mortality and their burden on the health care system. This proposal aims to provide resources that train young investigators at the MD or PhD level who will play a key role in extending our understanding of basic metabolic processes at the subcellular, cellular, organ and system level. Moreover, translating these new insights into both mechanistic and translational advances for disorders related to metabolic dysfunction.

PI_NAMEs: SCHERER, PHILIPP E (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Endocrine;Grant;Metabolism;Training

PROJECT_TITLE: ENDOCRINE & METABOLISM TRAINING GRANT

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project narrative There is an urgent need to evaluate whether new proposed presymptomatic Alzheimer's disease (AD) treatments are efﬁcacious in preventing cognitive decline. Current clinical endpoints, such as cognitive scores, are too noisy to access the cognitive decline after an intervention; however, neuroimaging can generate better biomarkers to monitor cognitive decline. We aim to develop a machine learning framework to extract useful biomarkers from neuroimaging data to predict cognitive decline, which then can be used as endpoints to evaluate presymptomatic AD treatments.

PI_NAMEs: JIANG, FEI  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Affect;Algorithms;Alzheimer's Disease;Area;Award;Benchmarking;Biological Markers;biomedical imaging;Biometry;Brain;career;Characteristics;Clinical;Cognitive;cognitive change;cognitive performance;cognitive testing;Data;Data Analyses;Dementia;Development;Doctor of Medicine;Doctor of Philosophy;early screening;efficacious treatment;Electroencephalography;Epidemiology;feature extraction;feature selection;Foundations;Functional Imaging;Functional Magnetic Resonance Imaging;Goals;high dimensionality;Image;imaging biomarker;imaging modality;Imaging Techniques;Impaired cognition;Individual;Intervention;Knowledge;Learning;machine learning framework;machine learning method;machine learning model;Mentors;method development;Methodology;Methods;Monitor;multidisciplinary;Multimodal Imaging;multimodal neuroimaging;Nature;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;Neurologic Dysfunctions;Neurology;Neurosciences;next generation;Pattern;Persons;predictive modeling;prevent;Procedures;radiological imaging;Research;Research Personnel;Rest;Risk Reduction;Sampling;statistical and machine learning;success;Symptoms;Technical Expertise;Testing;therapy design;Time;Training;treatment effect;Treatment Efficacy;United States;Validation;Work

PROJECT_TITLE: Development of Dynamic Resting State Functional Connectivity Machine Learning Framework for Dementia

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Rare Diseases

ORG_CITY: NEW ORLEANS

ORG_DEPT: BIOLOGY

ORG_NAME: XAVIER UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Principal Investigator/Program Director (Last, first, middle): Haye, Joanna, Elizabeth Project Narrative: DNA mismatch repair is a highly conserved process that functions to protect the integrity of the genome from prokaryotes to eukaryotes. In humans, defects in MMR results in Lynch syndrome, a cancer syndrome that results in colon and other types of cancers. The proposed project aims to provide further understanding of how MMR proteins are regulated and recruited to DNA, using the yeast Saccharomyces cerevisiae. PHS398 (Rev. 5/01) Page Continuation Format Page

PI_NAMEs: HAYE, JOANNA E (contact)

PROJECT_TERMS: Acetylation;Affect;Binding;Biological Assay;cancer type;Chromatin;chromatin immunoprecipitation;Colon;Complex;Defect;demethylation;Dependence;Dimerization;DNA;DNA biosynthesis;DNA-Directed DNA Polymerase;early onset colon cancer;Endometrial Carcinoma;Eukaryota;experimental study;Frequencies;gene repair;genetic manipulation;genetic predictors;Genetic Transcription;genome integrity;Genomic Instability;Hepatobiliary;Hereditary Neoplastic Syndromes;Hereditary Nonpolyposis Colorectal Neoplasms;histone methylation;histone modification;Histones;Human;Immunoblot Analysis;Investigation;Lysine;Maintenance;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Methylation;Methyltransferase;Microsatellite Instability;Mismatch Repair;Mismatch Repair Deficiency;Modeling;Modification;Mutagenesis;Mutagens;mutant;Mutation;overexpression;Pathway interactions;Polymerase Chain Reaction;Post-Translational Protein Processing;Principal Investigator;Process;programs;Prokaryotic Cells;Proteins;Proteomics;Publications;Publishing;recruit;Regulation;Repair Complex;repair function;Research;Role;Saccharomyces cerevisiae;Site;Small Intestines;Syndrome;Testing;Tissues;Two-Hybrid System Techniques;Urinary tract;Work;Yeasts

PROJECT_TITLE: Regulation and Localization of Mismatch Repair Proteins


NIH_SPENDING_CATS: Aging

ORG_CITY: CINCINNATI

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Ligands in the TGFβ family, specifically GDF11 and GDF8, have been implicated in regulating biological process affected by aging. Our work will characterize the different molecular states of GDF11 and GDF8 to help better understand how their activity is regulated by extracellular mechanisms during the aging process.

PI_NAMEs: THOMPSON, THOMAS B (contact)

PROJECT_TERMS: Affect;Age;age related;age related decline;Aging;aging process;animal old age;antagonist;Binding;Biochemical;Biological;Biological Process;biological systems;Buffers;cell growth regulation;Central Nervous System;Clinical;Clinical Trials;Complex;Coupled;Cues;design;Development;Engineering;Erythrocytes;experimental study;extracellular;Extracellular Protein;Family;Family member;Follistatin;GDF11 gene;GDF8 gene;Goals;grasp;Growth Factor;Heart;Human Biology;In Vitro;in vitro activity;in vivo;in vivo evaluation;interest;Laboratories;Ligand Binding;Ligands;Measurement;Mediator;Modeling;Molecular;morphogens;muscle form;N-terminal;novel;Peptide Hydrolases;Process;Production;Protease Domain;Publishing;Rationalization;Reagent;Receptor Signaling;Regulation;Rejuvenation;restoration;Role;Serum;Signal Transduction;Signaling Molecule;System;Testing;tool;Transforming Growth Factor beta;Work

PROJECT_TITLE: Regulation of GDF11 by extracellular mechanisms


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Studies show that virtually all increases in children’s (5-12yrs) BMI occur during the summer, no matter children’s’ weight status (ie, normal weight, overweight, or obese) at summer entry. Recent preliminary studies show that children engage in healthier behaviors on days that they attend summer day camps, and that BMI gain does not accelerate for these children. The proposed randomized dose-response study will identify the dose-response relationship between amount of summer programming and summer BMI gain.

PI_NAMEs: WEAVER, ROBERT G (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 8 year old;Acceleration;Address;Adult;Behavior;Body mass index;Child;Communities;contextual factors;cost effectiveness;COVID-19 pandemic;Development;Diet;dietary supplements;dosage;Dose;Environment;group intervention;Health;health goals;Health Policy;implementation determinants;implementation evaluation;implementation outcomes;Individual Adjustment;innovation;Intervention;Monitor;novel;Nutrient;Obesity;Obesity Epidemic;obesity in children;obesogenic;Outcome;Overweight;Participant;Pharmacologic Substance;Phase III Clinical Trials;Physical activity;prevent;programs;Public Health;Quasi-experiment;Randomized;Research;response;Schedule;school disruption;Schools;sedentary;Selection Bias;Sleep;Structure;Testing;Time;tv watching;virtual;Weight;Weight Gain;Work

PROJECT_TITLE: Identifying the Ideal Dose of Structured Summer Programming for Mitigating Accelerated Summer BMI Gain

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: FORT COLLINS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE The central dogma lies at the heart of gene regulation, but the coordinated dynamics of single- gene transcription and single-mRNA translation have yet to be visualized in living cells. This has made it difficult to measure the relative contributions of transcription and translation in complex gene networks that are deregulated in human disease. To address this shortcoming, we will develop and apply technology to image in up to four colors the full central dogma with single molecule resolution in living cells.

PI_NAMEs: STASEVICH, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Alleles;Cancer Etiology;Cell Line;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Colorado;Complex;Coupled;Coupling;Cytoplasm;Disease;Engineering;Epitopes;Failure;Gene Expression Regulation;gene network;Genetic Transcription;Genome engineering;Goals;Heart;histone modification;Hour;human disease;Image;Individual;Lead;Light;Malignant Neoplasms;Measures;Messenger RNA;Molecular Biology;mRNA Translation;Myosin ATPase;Organism;overexpression;Phenotype;pressure;Process;Regulation;Resolution;Role;single molecule;Sister;stem;Technology;Translating;Translations;Universities;Visualization

PROJECT_TITLE: Quantifying the coordinated dynamics of single-gene transcription and translation in living cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Untreated nonalcoholic steatohepatitis (NASH) can lead to life-threatening conditions such as cirrhosis or liver cancer. However, no FDA-approved therapy is available for NASH treatment. Improved understanding of the role of Txnip in the liver will have great potential to discover novel therapeutic strategies for NASH treatment.

PI_NAMEs: YANG, LING  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: adenoviral mediated;Adenoviruses;Affect;Anti-sense RNA;Apoptosis;Apoptotic;Binding;Binding Proteins;Biological Assay;CCAAT-Enhancer-Binding Proteins;Cell model;cell type;chronic liver disease;Cirrhosis;clinical application;Clinical Treatment;Clinical Trials;cost;Data;Dependovirus;Development;Diabetes Mellitus;Down-Regulation;Epidemic;FDA approved;gene function;Gene Proteins;Genes;Genetic;genetic manipulation;Genetic Transcription;genomic locus;Hepatic;Hepatocyte;Homologous Protein;Human;Impairment;improved;inhibitor;innovation;insight;knock-down;Knockout Mice;Kupffer Cells;Life;Liver;Malignant neoplasm of liver;Mediating;Metabolic;Metabolic Diseases;Modeling;Molecular;mouse model;Mus;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;Organ;overexpression;Pathogenesis;Pathogenicity;Patients;Pilot Projects;Play;polysome profiling;protein degradation;protein expression;protein function;Protein Inhibition;protein protein interaction;Proteins;Public Health;Regulation;Reporting;RNA;Role;Serotyping;small hairpin RNA;Stress;targeted treatment;Testing;Therapeutic;therapeutically effective;Tissues;transcription factor;Translations;TXNIP gene;ubiquitin-protein ligase;Ubiquitination;Untranslated RNA

PROJECT_TITLE: Regulation and Function of Thioredoxin Interacting Protein (Txnip) in Nonalcoholic Steatohepatitis (NASH)

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences;Nutrition

ORG_CITY: MINNEAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The next generation high-resolution high-performance neurometabolic imaging techniques as established in this project will enable quantitative and whole-brain imaging of key metabolic rates and other important neurophysiological parameters associated with major energy metabolism pathways in healthy and diseased human brain on an FDA-approved 7 Tesla clinical MRI scanner. The success of this project will provide translatable neuroimaging tools that can be applied in a wide range of biomedical, neuroscience and clinical research for assessing human brain energetic status and its changes. New insights from these areas of research are invaluable for understanding the energetic mechanisms of neurological disorders and ultimately improving our ability to diagnose, monitor progression, and assess the effects of treatments for brain diseases.

PI_NAMEs: CHEN, WEI  (contact);ZHU, XIAO-HONG

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Adenosine Triphosphate;Affect;Aging;aging brain;aging process;Area;ATP phosphohydrolase;Biochemical;Bioenergetics;Biomedical Research;Brain;Brain Diseases;Brain imaging;Brain Neoplasms;Cell Respiration;Cerebrovascular Circulation;Cerebrum;Citric Acid Cycle;Clinical;clinical application;Clinical Research;Collaborations;Complex;Consumption;Creatine Kinase;detection sensitivity;Deuterium;Diagnosis;Disease;Energy Metabolism;Energy Metabolism Pathway;Engineering;Face;FDA approved;Glucose;glucose metabolism;Glycolysis;Goals;Health;Homeostasis;Human;human disease;Image;imaging capabilities;imaging detection;Imaging Device;imaging facilities;imaging modality;Imaging Techniques;improved;innovation;insight;kinetic model;Leadership;Life;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Malignant Neoplasms;Maps;Measurement;Measures;member;Mental disorders;Metabolic;metabolic imaging;Metabolic Pathway;metabolic rate;Methods;Mitochondria;Monitor;Motor;Nervous System Disorder;Neurodegenerative Disorders;neuroimaging;Neurons;neurophysiology;Neurosciences Research;next generation;Nicotinamide adenine dinucleotide;NMR Spectroscopy;Noise;non-invasive imaging;novel;Nuclear;Oxidation-Reduction;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;Pathway interactions;Patients;Performance;Phosphorus;Physiological;Pilot Projects;Play;Process;Production;quantitative imaging;radio frequency;Reaction;Research;Research Design;Resolution;Resources;response;Role;Scanning;Signal Transduction;skills;spatiotemporal;Stroke;success;Technology;temporal measurement;Testing;Time;tool;translational applications;translational study;treatment effect;tumor heterogeneity;Visual

PROJECT_TITLE: Establishing translational neuroimaging tools for quantitative assessment of energy metabolism and metabolic reprogramming in healthy and diseased human brain at 7T

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE This project aims to fill a key knowledge gap by conducting an unprecedented evaluation of the molecular landscape of the tumor and tumor microenvironment in a large sample of Alaska Native colorectal cancer (CRC) patients using cutting-edge molecular profiling technologies. Results from this project will improve our understanding of CRC tumorigenesis, molecular subtypes, and clinically actionable mutational, genetic, and immune-related features in the Alaska Native people who experience the highest CRC incidence and mortality rates worldwide. Insights gained through this work may inform the development of novel therapeutic strategies, may result in clinically useful predictors of CRC-specific death that can be used to guide clinical decision making, and, ultimately, decrease mortality.

PI_NAMEs: HUYGHE, JEROEN R (contact);PETERS, ULRIKE ;REDWOOD, DIANA

PROGRAM_OFFICER_NAME: MECHANIC, LEAH E

PROJECT_TERMS: actionable mutation;Address;Alaska;Alaska Native;Alaska Native population;Area;biobank;Biological;Biological Sciences;Biological Specimen Banks;Cancer Biology;cancer cell;Cancer Center;cancer diagnosis;cancer health disparity;Cells;Cessation of life;Characteristics;Clinical;clinical decision-making;clinically actionable;Collaborations;colon cancer patients;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;Colorectal Neoplasms;Communities;Data;Death Rate;Dedications;Development;Diagnosis;digital;Disease Progression;Disparity;Ensure;Environmental Exposure;Epidemiology;Etiology;Evaluation;exome sequencing;experience;Formalin;Gene Expression;Genes;Genetic;Genetic Transcription;Germ-Line Mutation;Goals;high risk;high risk population;Immune;Immune Evasion;Immune response;improved;improved outcome;Incidence;insight;Institutional Review Boards;Knowledge;Link;long-standing disparities;Medical Records;member;Molecular;Molecular Profiling;molecular subtypes;Monitor;mortality;Mutation;nano-string;Not Hispanic or Latino;novel;novel therapeutic intervention;novel therapeutics;Outcome;Paraffin Embedding;Pathogenicity;Pathway interactions;Patients;Penetrance;Phenotype;Population;Prognostic Marker;programs;Research;Research Priority;Resolution;Resources;risk variant;Role;Sampling;screening;Selection for Treatments;Somatic Mutation;spatial relationship;Technology;The Cancer Genome Atlas;Time;Tissue Sample;transcriptome;transcriptomic profiling;transcriptomics;translational goal;translational impact;translational potential;tribal health;Tribes;tumor;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;tumorigenesis;Validation;Variant;Work

PROJECT_TITLE: Deep molecular and cellular profiling of colorectal cancer tumor and immune microenvironment in Alaska Native people

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Psychosis;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the choroid plexus has been implicated in neurodevelopment and a range of brain disorders. Evidence demonstrates that the choroid plexus is critical for brain maturation, immune/inflammatory regulation, and behavioral/cognitive functioning, however current neuroimaging segmentation tools are poor at accurately and reliably segmenting the choroid plexus. The proposed studies will utilize large patient cohorts (n=22,000+) from high resolution (Human Connectome Project and Connectome Related Human Disease) and conventional (inclusive of high risk for psychosis, first episode and chronic psychosis, bipolar disorder, and Alzheimer’s disease) neuroimaging datasets to develop an open- source deep learning choroid plexus segmentation method that will be used to elucidate changes in the choroid plexus across the lifespan and within various brain.

PI_NAMEs: LIZANO, PAULO L (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Adult;Age;age related;Aging;Alzheimer's Disease;American;Area;Behavioral;Bipolar Disorder;Brain;Brain Diseases;Brain scan;Cerebral Ventricles;Cerebrospinal Fluid;Chronic;cognitive function;cohort;Communities;comparison control;Computer software;computerized tools;connectome;connectome data;Data;data acquisition;Data Set;Dedications;deep learning;Development;Disease;disease classification;Elderly;Ensure;Ethnic Origin;experience;Goals;high risk;Homeostasis;Horns;Human;human disease;Image;imaging biomarker;imaging capabilities;Immune;Immunologics;improved;Individual;Inflammatory;innovation;interest;Knowledge;Label;Lateral;Learning;life span;Link;Longitudinal Studies;Magnetic Resonance Imaging;Manuals;Maps;Methods;Morphology;morphometry;National Institute of Mental Health;neglect;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;neuroimaging marker;neuroimmunology;Neurology;neuronal patterning;neuropsychiatric disorder;neuropsychiatry;Neurosciences;novel;novel strategies;open source;Pathologic;Patients;Physiology;Play;Process;Psychiatry;Psychoses;psychosis risk;Public Health;Race;Regulation;repaired;Research;Research Personnel;Resolution;Role;Sampling Studies;schizophrenia spectrum disorder;secondary analysis;sex;Socioeconomic Status;Source;Structure;Structure of choroid plexus;Subgroup;Techniques;Testing;Time;Tissues;tool;Training;treatment strategy;ultra high resolution;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: FastPlex: A Fast Deep Learning Segmentation Method for Accurate Choroid Plexus Morphometry


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Autism;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: DREXEL UNIVERSITY

PHR: This project will use data from two prospective cohorts to examine whether nutrients modify the relationship between prenatal air pollution exposure and autism spectrum disorder (ASD)-related outcomes. We will examine joint effects of individual nutrients (prenatal folate, polyunsaturated fatty acids (PUFAs), and vitamin D), as well as broader diet, with particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone exposures in association with risk of quantitative ASD-related traits as well as ASD diagnosis, and will consider potential critical time windows for these interactions. Because diet is a readily accessible, individual-level modifiable factor, this line of research presents the potential for a large public health impact.

PI_NAMEs: LYALL, KRISTEN  (contact);VOLK, HEATHER E

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: Accounting;Address;Age;Air Pollutants;Air Pollution;Allergic Disease;Area;Asthma;Attenuated;attenuation;autism spectrum disorder;autistic children;Bayesian Method;Carbon;Categories;Chemical Exposure;Child;cohort;Collection;Data;Diagnosis;Diagnostic;Diameter;Diet;dietary;Dietary Factors;Dietary Intervention;Dimensions;disorder risk;Environmental Risk Factor;Etiology;experience;Exposure to;Folic Acid;Food;Frequencies;General Population;high dimensionality;high risk;Individual;Intake;Investigation;Joints;Linear Regressions;Logistic Regressions;Measures;Metabolism;Methods;Modeling;Modification;Morbidity - disease rate;Mothers;neurodevelopment;Nitrogen Dioxide;Nurses;Nurses' Health Study;Nursing Students;Nutrient;Outcome;Ozone;ozone exposure;Participant;Particulate Matter;Pathway interactions;pollutant;pollutant interaction;Polyunsaturated Fatty Acids;Population;Pregnancy;prenatal;prenatal exposure;prospective;Prospective cohort;Public Health;Publishing;Questionnaires;Reporting;Research;Research Domain Criteria;Risk;Risk Factors;Risk Reduction;Role;social;Testing;Time;trait;Vitamin D;Vitamins;Work

PROJECT_TITLE: Examining dietary modifiers of associations between air pollution and autism-related outcomes in two cohorts

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative The proposed research is relevant to public health because ascending thoracic aortic aneurysms and dissections are frequent causes of death in the United States, largely because current medications are ineffective. The project is relevant to the NHLBI’s mission because it focuses on the treatment and prevention of life-threating cardiovascular disease; the development of new, effective medications would prevent the progression of aortic disease and save the lives of patients with these conditions.

PI_NAMEs: GHAGHADA, KETAN B;LEMAIRE, SCOTT A;SHEN, YING H (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Aneurysm;Angiotensin II;Aorta;Aortic Diseases;Apoptosis;Attention;Blood;Cardiovascular Diseases;Cause of Death;Cell Death;cell injury;Cells;Cessation of life;Chromatin;Chromatin Remodeling Factor;contrast enhanced computed tomography;Data;Development;Disease;Disease Progression;Dissection;DNA;DNA Damage;Elastic Fiber;Endothelial Cells;endothelial dysfunction;Endothelium;Enhancers;Epigenetic Process;epigenomics;Event;experimental study;Extravasation;Functional disorder;Genes;High Fat Diet;Human;Image;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;Infusion procedures;inhibitor;insight;Interferon Activation;Investigation;IRF3 gene;Life;Link;Lytic;Medial;Mediating;Microdissection;Mission;Modeling;Molecular;mouse model;Mus;nanoparticle;National Heart, Lung, and Blood Institute;novel;Pathogenesis;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Population;prevent;Prevention;programs;promoter;Protein Kinase Interaction;Public Health;Receptor Up-Regulation;receptor upregulation;Receptor-Interacting Protein;Research;Role;Rupture;sensor;Series;Signal Pathway;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;SMARCA4 gene;Smooth Muscle Myocytes;Stress;TBK1 gene;Testing;therapeutic target;Thoracic Aortic Aneurysm;transcription factor;transcriptomics;United States;Up-Regulation;Wild Type Mouse

PROJECT_TITLE: Endothelial Dysfunction in the Development of Aortic Degeneration, Dissection, and Rupture

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-D(02)M]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Lymphatic Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Cancer draining lymph nodes are important for the generation and maintenance of anti-cancer immune responses. However, the presence of metastatic cancer cells in these lymph nodes inhibits immune responses and the efficacy of new therapies intended to boost anti-cancer immunity. In the proposed work, we will identify and overcome the mechanisms of immune suppression in metastatic lymph nodes to improve therapeutic outcomes for patients with metastatic cancer.

PI_NAMEs: PADERA, TIMOTHY P (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: anti-cancer;Automobile Driving;Biological Markers;Biometry;Blood Vessels;Breast Cancer Patient;cancer biomarkers;cancer cell;Cancer Patient;CD4 Positive T Lymphocytes;CD86 gene;Cells;cellular engineering;clinical translation;clinically relevant;Data;Disseminated Malignant Neoplasm;Distant Metastasis;draining lymph node;Ensure;Epithelium;Excision;Generations;Goals;High Endothelial Venule;Histocompatibility Antigens Class II;Immune;immune checkpoint blockade;Immune response;Immunity;Immunology;Immunosuppression;Immunotherapy;Impairment;improved;Infiltration;inhibitor;Interferon Type II;Invaded;Knock-out;Laboratories;Lesion;Losartan;lymph nodes;Lymphocyte;Lymphocyte Activation;Lymphocyte Suppression;Lymphocytic Infiltrate;Maintenance;Malignant Lymph Node Neoplasm;Malignant Neoplasms;Measures;Metastatic Neoplasm to Lymph Nodes;MHC Class II Genes;Neoplasm Metastasis;novel;novel therapeutics;Pathology;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Phenotype;Play;prevent;Prognosis;programs;Publishing;Recommendation;Regulatory T-Lymphocyte;Research;Resources;response;Role;Signal Transduction;success;Systemic Therapy;Systems Biology;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapy development;therapy outcome;Time;translational approach;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Work

PROJECT_TITLE: Targeting lymph node metastases to block cancer progression

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Clinical Research;Hematology;Orphan Drug;Rare Diseases;Sickle Cell Disease

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE In sickle cell disease (SCD), red blood cell-derived extracellular vesicles (REVs) are at elevated concentrations, and are capable of independently initiate inflammation and thrombosis, promoting clinical complications. This proposal will leverage microfluidic systems and functional assays to elucidate the roles of REVs in complement activation and thromboinflammation, and to use REVs as a biomarker to evaluate complement activation and thromboinflammation in individuals with SCD. This project will yield a more precise evaluation of clinical outcomes, as well as effective screening and selection of candidate therapeutic interventions in SCD, and the knowledge that will be gained in this project can be adapted to other hemolytic disorders such as atypical hemolytic uremic syndrome.

PI_NAMEs: AN, RAN  (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Abnormal Red Blood Cell;Acetylcysteine;Adhesions;Animal Model;Autologous;Award;Biological Assay;Biological Markers;Biomedical Research;Blood specimen;Blood Vessels;candidate selection;Caring;Cell Adhesion;Cell surface;Cells;Characteristics;Chemical Engineering;Clinical;Coagulation Process;comorbidity;Complement;Complement Activation;complement system;Cytolysis;Data;Databases;Deep Vein Thrombosis;Deoxygenated Sickle Hemoglobin;Deposition;Diagnosis;Disease;Disease Outcome;Drug Metabolic Detoxication;emergency settings;Endothelial Cells;Endothelium;Enzyme-Linked Immunosorbent Assay;Erythrocytes;Evaluation;Exhibits;experience;Exposure to;extracellular vesicles;Generations;GKLF protein;Heme;Hemolysis;Hemolytic-Uremic Syndrome;Hemopexin;hydroxyurea;Hypoxemia;Hypoxia;improved;In Vitro;Individual;individual patient;Inflammation;Inflammatory;Inpatients;Knowledge;Laboratories;Lead;Malaria;Mediating;Membrane Proteins;Microfluidics;Morbidity - disease rate;mortality;Mus;Mutation;novel therapeutics;Outcome;Outpatients;Oxidative Stress;Pain;Parents;Pathologic;Pathway interactions;patient population;patient response;Patients;Periodicity;Persons;Phenotype;Phosphatidylserines;Physiological;Plasma;Play;polymerization;Polymers;Population Heterogeneity;pre-clinical assessment;predict clinical outcome;Predisposition;Process;Prognosis;Property;protein expression;Proteomics;Recording of previous events;Regulation;research clinical testing;response;Reverse Transcriptase Polymerase Chain Reaction;Risk;Role;Sampling;Scientist;screening;shear stress;Sickle Cell;Sickle Cell Anemia;Sickle Hemoglobin;Stress;Surface;Suspensions;System;targeted treatment;Testing;Therapeutic Intervention;Thrombin;thromboinflammation;Thrombosis;Thrombus;Transcriptional Regulation;Transfusion;Treatment Efficacy;treatment response;vascular inflammation;vesicular release;Western Blotting;White Blood Cell Count procedure

PROJECT_TITLE: Roles of Red Blood Cell Derived Extracellular Vesicles in Complement Activation and Thromboinflammation in sickle cell disease

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Resolving Spatiotemporal Determinants of Cell Specification in Corticogenesis with Latent Space Methods Applicant: Genevieve Stein-O’Brien, PhD MHS Proper development of the brain requires precise regulation and coordination of spatiotemporal cues. We hypothesize human genetic variation manifests phenotypic differences by introducing small biases in spatiotemporal determinants that have accumulated effect over development. To test this hypothesis, we build novel computational and experimental tools to resolve transcriptional regulation of anatomical identity (space) and cell cycle length (time) in the brain and apply these tools to induced pluripotent stem cells from ALS patients in a model of brain development to show the effect of genetic background.

PI_NAMEs: STEIN-O'BRIEN, GENEVIEVE LAUREN (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Algorithms;ALS patients;analytical tool;Anatomy;Automobile Driving;Bar Codes;Behavioral;Biological;Biological Assay;biological systems;Brain;BRAIN initiative;Brain region;Catalogs;CCRL2 gene;Cell Cycle;Cell Cycle Regulation;cell type;Cells;Censuses;Central Nervous System;Classification;Collection;Competence;Complex;Computer Models;Computer software;Coupled;CRISPR/Cas technology;Cues;Data;data integration;Data Set;Development;dimension reduction;Dimensions;Disease;Doctor of Philosophy;Experimental Models;functional plasticity;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;Genetic Markers;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;Goals;high dimensionality;Human Genetics;human induced pluripotent stem cells;improved;In Situ;Individual;induced pluripotent stem cell;Knowledge;Learning;Length;Link;Location;Machine Learning;Measurement;Methodology;Methods;Modeling;Molecular;multimodal data;Multiomic Data;Nature;nervous system development;neural;neural circuit;Neurodegenerative Disorders;neuronal circuitry;Neuronal Plasticity;neuropsychiatric disorder;novel;nucleotide analog;Pathway interactions;Pattern;Performance;Phase;Phenotype;Physiologic pulse;Positioning Attribute;Probability;Process;progenitor;Regulation;repository;Research;Retina;single-cell RNA sequencing;spatial integration;spatiotemporal;Specific qualifier value;Statistical Models;statistics;Stochastic Processes;success;supervised learning;System;Techniques;Testing;Time;time use;tool;Training;Transcriptional Regulation;transfer learning;Validation;Variant;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Alzheimer's disease is a devastating neurodegenerative disorder resulting in cognitive impairment and progressive dementia, and currently no effective cure has been identified. Our proposed studies aim to understand the multifactorial role and underlying mechanisms of action of an E3 ubiquitin ligase IDOL in AD pathology. This research will have the potential to reveal a novel therapeutic target for the treatment of Alzheimer’s diseases.

PI_NAMEs: GAO, JIE  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Acute;Adult;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Alzheimer's disease risk;Amyloid beta-Protein;Amyloidosis;Antisense Oligonucleotides;Apolipoprotein E;APP-PS1;beta amyloid pathology;Brain;cell type;Cells;Chronic;Cognitive deficits;cognitive function;Data;Dementia;Deposition;Disease associated microglia;excitatory neuron;Excitatory Synapse;extracellular;Functional disorder;Genetic;genetic manipulation;Genetic Transcription;Genotype;glial activation;Glutamates;Goals;Heterogeneity;Human;Impaired cognition;improved;in vivo;knock-down;Knock-in;Knock-in Mouse;Knockout Mice;LDL-Receptor Related Protein 1;Lipoprotein Receptor;Lipoproteins;Long-Term Effects;Long-Term Potentiation;Low Density Lipoprotein Receptor;LoxP-flanked allele;Mediating;member;Metabolic;Metabolism;Microglia;Molecular;mouse model;Mus;Myeloid Cells;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurons;neuropathology;neurotransmission;new therapeutic target;novel;Pathogenesis;Pathologic;Pathway interactions;Phagocytes;Phagocytosis;Play;Population;Postsynaptic Membrane;posttranscriptional;receptor;Recycling;Research;response;Role;Senile Plaques;Signal Transduction;Surface;Synapses;synaptic function;Synaptic Transmission;Tamoxifen;targeted treatment;tau Proteins;Testing;Therapeutic;Therapeutic Intervention;transcriptome;transcriptomics;Transgenic Mice;ubiquitin-protein ligase;uptake;VLDL receptor

PROJECT_TITLE: Targeting IDOL-ApoE receptor pathway in Alzheimer's disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Telehealth;Unintentional Childhood Injury

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE Healthy People 2020 has identified motor vehicle crashes as a significant public health issue for teenagers and young adults, and cellphone-related distracted driving has been recognized as an epidemic hazard in traffic safety, particularly among young drivers whose cellphone use and crash rate are high. The findings of this study will determine the effectiveness of a cellphone app and driving mode in reducing cellphone use and high- risk driving events. This study will help inform public health and safety researchers and organizations, cellphone service providers, and cellphone manufacturers regarding the use of cellphone apps and driving modes for reducing cellphone-related distracted driving in this population.

PI_NAMEs: ZHU, MOTAO  (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Acceleration;Accidents;Address;Adult;Age;aged;Android;Apple;Applications Grants;arm;Automobile Driving;Behavior;Behavior Therapy;Cellular Phone;Cessation of life;Clinical Trials;Computer software;cost;Data;Data Reporting;Databases;design;distracted driving;distraction;driving behavior;driving safety;Effectiveness;effectiveness evaluation;Emergency Situation;Epidemic;Event;feasibility testing;Future;Goals;hazard;Healthy People 2020;high risk;Injury;innovation;Intervention;Manuals;Manufacturer;Methods;mobile computing;multidisciplinary;new technology;Outcome;Participant;Patient Self-Report;pilot test;Police;Population;primary outcome;prospective;Public Health;Publishing;Randomized;randomized trial;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Risk;risky driving;Safety;Sample Size;service providers;smartphone application;societal costs;Technology;Teenagers;Telephone;Text;Text Messaging;three-arm trial;Time;Vehicle crash;Work;young adult;Young driver

PROJECT_TITLE: Randomized trial on mobile technology to reduce young drivers’ cellphone use

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project narrative The proposed project is relevant to public health because it is expected to identify a set of objective markers of emotional reactivity, speech preparation and production and cognitive control vulnerabilities that are identifiable very early in development and contribute to the onset and pathogenesis of stuttering. The identification of these markers of risk for stuttering persistence, in combination with other predictors of stuttering, will allow clinicians to better pinpoint targets for assessment, set the stage for novel therapeutic approaches, and allow researchers to better evaluate the effects of early intervention due to an improved ability to distinguish persistent from transient cases. Thus, the proposed research supports the mission of NIDCD by discovering new knowledge that has the potential to improve health and outcomes of young children who stutter.

PI_NAMEs: JONES, ROBIN MICHAEL (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: 4 year old;Address;Adult;Age;Age Months;Age Years;Anxiety;Articulation;Behavioral;Biological Markers;biomarker identification;Child;Childhood Stuttering;Clinical;Clinical assessments;Cognitive;cognitive control;comorbidity;Contingent Negative Variation;Data;design;Development;Developmental Stuttering;Diagnostic;early childhood;Early Intervention;Education;Emotional;Emotions;Enrollment;Event-Related Potentials;Galvanic Skin Response;Health;improved;improved outcome;indexing;Knowledge;Language;Longitudinal cohort study;Longitudinal Studies;longitudinal, prospective study;Measures;Methodology;Methods;Mission;National Institute on Deafness and Other Communication Disorders;novel;novel marker;novel therapeutic intervention;Outcome;outcome prediction;Pathogenesis;Performance;Physiological;Play;predictive modeling;Predictive Value;Preparation;Process;Production;prognostic indicator;Prospective cohort;Public Health;Reaction Time;Research Personnel;Research Support;response;Risk;Risk Factors;Risk Marker;Role;School-Age Population;Severities;sex;social;Speech;Speech Development;Stuttering;Task Performances;Temperament;Testing;Time;Translating;Visit;Vocation;Work

PROJECT_TITLE: Early childhood stuttering and risk for persistence: The impact of emotion on speech and cognitive control

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Pediatric;Prevention

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: YORK UNIVERSITY

ORG_STATE: ON

ORG_ZIPCODE: M3J 1P3

PHR: Project Narrative Controversy about the safety of water fluoridation has led scientific advisory groups to recommend additional research on fluoride toxicity. This study will use a novel biomarker (dentin) to rigorously test the safety of chronic fluoride exposure among potentially vulnerable populations at levels relevant to the U.S. and Canada. The use of the dentin matrix will allow us to measure chronic fluoride exposure levels and to identify the possibility of discrete periods of susceptibility.

PI_NAMEs: LANPHEAR, BRUCE P;TILL, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Acquired Dental Fluorosis;Adult;Adverse effects;analytical method;Archives;Attention;Attention deficit hyperactivity disorder;Behavior;biobank;Biological Markers;Birth;Brain;Canada;Child;Childhood;Chronic;cohort;comparison group;cost;Country;critical period;Data;deciduous tooth;Decision Making;Dental caries;Dental Enamel;Dentin;Development;Dose;early childhood;early life exposure;Endocrine disruption;environmental chemical;Exposure to;Fetal Development;Fetus;First Pregnancy Trimester;Fluorides;Funding;Goals;Grant;Growth;Health;Human;Hyperactivity;inattention;Infant;Infant formula;Ingestion;innovation;Iodine;Maps;Measurement;Measures;Mediating;Mediation;Methods;Modeling;National Research Council;neurobehavioral;neurotoxic;neurotoxicity;North America;novel marker;Outcome;Parents;Persons;postnatal;Powder dose form;Predisposition;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Preschool Child;prevent;Problem behavior;public drinking;Public Health Practice;public health relevance;Recommendation;Recording of previous events;Research;Resources;Risk;Risk Factors;Safety;safety testing;Sample Size;Sampling;sex;Sex Differences;Spottings;Structure;Testing;thyroid disruption;Thyroid Function Tests;Thyroid Gland;Thyroid Hormones;Time;Tissues;Tooth Discoloration;Tooth structure;Toxic effect;toxic metal;United States;United States National Institutes of Health;urinary;Urine;Vulnerable Populations;Water fluoridation;Water Supply

PROJECT_TITLE: Fluoride in Tooth Dentin and Neurodevelopmental Outcome in a Canadian Cohort

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The Neuroscience Training Program (NTP) at the University of Wisconsin–Madison provides integrated predoctoral neuroscience training, equipping students to carry out research aimed at understanding fundamental neurobiological processes and mechanisms underlying diseases and disorders of the nervous system. Our goal is to prepare our students to lead the next generation of scientists with independent careers in academia, healthcare, teaching, industry, and public service.

PI_NAMEs: ROSENBERG, ARI  (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurosciences;Training Programs

PROJECT_TITLE: Neuroscience Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (03)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE A renewal of our T32 pre- and post-doctoral training grant (T32EY027721) is being submitted to continue to provide research training in basic science disciplines relevant to vision research and to support interdisciplinary, collaborative and translational research so that trainees are prepared to enter and compete within emerging, interactive research environments. The Vision Research Training Program (VRTP) represents a collaborative interaction between the Department of Ophthalmology and Visual Sciences (DOVS) in the School of Medicine and Public Health (SMPH) and the McPherson Eye Research Institute (MERI) at the University of Wisconsin-Madison. The interdisciplinary training supported by the grant will cross traditional department, school, and institute boundaries and will provide exceptional scientific training as well as provide a structure for interactions with clinical scientists and clinicians to meet the goal of understanding, preventing and treating diseases of the visual system. Eighteen faculty currently comprise the group of eligible trainers in the proposal, and they are organized according to four areas of research emphasis: (a) Development and Diseases of the Anterior Segment of the Eye, (b) Development and Diseases of the Posterior Segment of the Eye; (c) Ocular Epidemiology and Genetics; (d) Higher Order Visual Processing.

PI_NAMEs: NICKELLS, ROBERT W (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Training Programs;Vision research

PROJECT_TITLE: Vision Research Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (05)]


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Our predoctoral Neuromuscular Plasticity Training (NMPT) program provides a diverse group of Trainees with a common foundation in rehabilitation and translational science. Over the last funding cycle, the program has supported 18 Trainees including physical therapists, speech-language therapists, and basic science trainees. Graduates leave the program with an established professional network of rehabilitation scientists, experience with interactive scientific presentations, and foundational knowledge in neuromuscular plasticity in the context of rehabilitation.

PI_NAMEs: FULLER, DAVID D (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TITLE: Fuller T32 renewal

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-R (90)]


ADMINISTERING_IC: OD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project narrative We present our proposal to acquire a Perkin Elmer IVIS SpectrumCT instrument that will be installed in the Einstein IVIS core facility. This technology is important for studies in cancer biology and infectious diseases and is a critical need for 40 different investigator laboratories at Einstein. Our current IVIS instrument is over 12 years old and service by the vendor will be discontinued. In addition, parts are also difficult to obtain due to age of the instrument. Overall, a replacement instrument is urgently needed to maintain reliable IVIS access for investigators.

PI_NAMEs: WEISS, LOUIS M. (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: 12 year old;Acquired Immunodeficiency Syndrome;Age;Animals;Cancer Biology;Cancer Center;cell motility;college;Communicable Diseases;Computer software;Computer Systems;Core Facility;Data;Engineering;Fluorescence;Funding;Image;imaging system;in vivo imaging system;Individual;instrument;Laboratories;Life;Luciferases;Measurement;Medicine;Monitor;Mus;pathogen;Pathogenesis;Research;Research Design;Research Personnel;Research Project Grants;Services;Source;Support System;System;Time;tumor;United States National Institutes of Health;Update;Vendor

PROJECT_TITLE: IVIS SpectrumCT

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-M (30)]


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE: The goal of this application is to prepare MD, MD/PhD pediatricians, and PhD basic scientists for careers in independent research on topics relevant to digestive diseases in infancy, childhood, and adult life. Post-doctoral training in both basic and clinical research relevant to the GI tract is provided.

PI_NAMEs: SNAPPER, SCOTT B (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TITLE: Training in Pediatric Gastroenterology, Hepatology, and Nutrition

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-W (J1)]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Diabetes is a public health epidemic, with a prevalence of greater than 10% in the United States. Diabetes and associated metabolic disorders cause significant health complications and generate enormous costs for healthcare systems. In order to develop new and more effective treatments and care strategies for those affected by diabetes and other metabolic disorders, there is a critical need for researchers in this space who can change the course of diabetes through discovery, analysis, and development of new care strategies. The Duke University T32 Research Training Program in Endocrinology and Metabolism will leverage its world-class faculty, resources, and environment to combat the diabetes epidemic by recruiting and training outstanding physicians and medical scientists for careers in diabetes and metabolism research.

PI_NAMEs: D'ALESSIO, DAVID A. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Endocrinology;Training Programs

PROJECT_TITLE: Endocrinology and Metabolism Training Program

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Brain Disorders;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: Project Narrative This training program is directly related to improving treatment and reducing disability for millions of children and adults with disorders of the nervous system. Our focus is on training MD and PhD researchers to develop and assess new rehabilitation approaches for people suffering from many different disorders of the nervous system, including traumatic brain injury, stroke, and developmental brain disorders.

PI_NAMEs: BASTIAN, AMY J. (contact)

PROJECT_TERMS: Brain Injuries;Neurological disability;Rehabilitation therapy;Research Training

PROJECT_TITLE: Research Training in Rehabilitation for Brain Injury and Neurological Disability


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The multidisciplinary University of Alabama at Birmingham Training Program in Brain Tumor Biology is focused on preparing highly motivated pre-doctoral and MD/PhD students for a career in fundamental and translational brain tumor research. Trainees are therefore selected for their commitment to neuro-oncology research and excellent performance in the first two years of the UAB Graduate Biomedical Sciences Program. Our dedicated and collaborative training environment provides the ideal setting for implementation of an educational program in brain tumor research.

PI_NAMEs: HJELMELAND, ANITA BORTON (contact)

PROJECT_TERMS: Brain Neoplasms;Training Programs;Tumor Biology

PROJECT_TITLE: Training Program in Brain Tumor Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-R (15)]


ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative The renewal of the Ruth Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (T32) ‘Training the Next Generation of Surgeon-Scientists in Pancreatology,’ will enable training of future surgeon-scientists in collaborative, transdisciplinary, translational research in diseases of the pancreas. The program will train surgical residents and fellows, providing each with the core competencies needed to develop into independent, productive researchers poised to make lasting contributions through collaborative, team-based research.

PI_NAMEs: BEILMAN, GREGORY J;YAMAMOTO, MASATO  (contact)


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Our program will train the next genera2on of researchers to overcome challenges posed by the growing threat of neurological diseases and disorders on an expanding senior popula2on. The training focuses on leveraging the explosion of new tools for understanding nervous system func2on in combina2on with a clinical understanding of neurological condi2ons and advanced methods in computa2on, data science, and machine learning. Trainees will tackle problems fundamental to advancing technology-based treatments for neurological diseases such as Parkinson’s disease, epilepsy, and depression.

PI_NAMEs: BORICH, MICHAEL ROBERT;ROZELL, CHRISTOPHER JOHN;STANLEY, GARRETT B. (contact);TING, LENA H

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Engineering;neural;Training

PROJECT_TITLE: Training in Computational Neural Engineering

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-D (J1)]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: We propose to renew our Comprehensive Musculoskelelal Training Program , which has been highly successful in training the next generation of musculoskelelal biologists, physicians, and engineers for research careers in MSK. We will offer trainee positons from three to four for each group: predoctoral students, postdoctoral fellows, and summer medical student interns. The training program will integrate current musculoskeletal research and teaching programs in the basic, clinical, and engineering sciences through the Indiana Center for Musculoskeletal Health, and train young scientists for research careers as basic scientists, bioengineers, clinical and translational investigators pursuing the causes of, and solutions to, musculoskelelal disease.

PI_NAMEs: ROBLING, ALEXANDER G (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Musculoskeletal;Training Programs

PROJECT_TITLE: Comprehensive Musculoskeletal Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M1)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: NARRATIVE Animal species differ dramatically in their aging rates and susceptibility to age-related diseases including Alzheimer’s disease. This Program Project Grant will identify mechanisms responsible for longevity and disease resistance in long-lived mammals. This knowledge will enable the development of novel interventions to extend human healthspan and treat Alzheimer’s disease based on longevity mechanisms selected by millions of years of evolution.

PI_NAMEs: GORBUNOVA, VERA  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;African;Age;age-related disease;Aging;aging clocks;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amino Acids;animal colony;Animal Model;Animals;anti aging;Balaena;Bioinformatics;Biological Markers;Biology;Brain;Cell Separation;Cells;Centenarian;Chemicals;circadian;Collaborations;Collection;Comparative Biology;comparative genomics;Comparative Study;computerized tools;Cytoplasm;Data;Dedications;Development;Disease Resistance;Disparity;DNA;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Elements;enzyme deficiency;Enzymes;epigenetic clock;Epigenetic Process;epigenome;Evolution;Gene Expression;Genes;Genome;Genome Stability;Goals;HAS2 gene;Health;healthspan;Hematopoietic System;histone modification;Human;improved;induced pluripotent stem cell;Inflammation;insight;Intervention;Knowledge;life span;Link;Longevity;Maintenance;Mammals;Mass Spectrum Analysis;Mediating;Methionine;methionine sulfoxide reductase;methylome;Mole Rats;Molecular;Molecular Profiling;mouse model;multiple omics;Mus;Mutagenesis;Mutation;Mutation Analysis;novel;Octodon;Pathology;Pathway interactions;Phase;pluripotency;Positioning Attribute;Predisposition;prevent;Process;Program Research Project Grants;programs;Proteins;Proteomics;rate of aging;Regulation;Research;Research Personnel;resilience;Resistance;Resources;Rodent;Role;Shrews;single molecule;Stimulator of Interferon Genes;synergism;Techniques;Testing;therapy development;Tissues;tool;transcriptome;transcriptome sequencing;Transgenes;Whales;Wild Type Mouse;Work

PROJECT_TITLE: Comparative genomics of longevity and Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-D (J3)]