NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Aging, particularly the increased incidence of disease in older individuals, is emerging as one of the most important health concerns in the United States, yet every individual ages differently. Understanding how different genetic backgrounds influence aging, especially how these differences influence the response to drugs and other aging interventions, is key to implementing strategies that increase the period of healthy aging in humans.

PI_NAMEs: PHILLIPS, PATRICK C. (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;Age;Aging;aging clocks;aging mechanism;aging population;aging related;Alleles;Animals;Biological;biological adaptation to stress;biological systems;Biology of Aging;Caenorhabditis;Caenorhabditis elegans;Cells;Chemicals;Chromosome Mapping;Chronic Disease;Clustered Regularly Interspaced Short Palindromic Repeats;Dementia;Development;Disease;Engineering;Event;functional genomics;Gene Expression Profile;Generations;Genes;Genetic;Genetic Crosses;genetic manipulation;Genetic Recombination;Genetic study;Genetic Transcription;Genetic Transformation;Genetic Variation;genome editing;Genomics;Health;Healthcare;healthspan;healthy aging;Heart Diseases;Human;Incidence;Individual;individual variation;insight;interest;Intervention;Knock-out;Laboratories;Life;Life Expectancy;life span;Longevity;Malignant Neoplasms;Maps;Mediating;model organism;Modeling;Molecular Biology;Musculoskeletal;mutant;Nematoda;novel;Older Population;Organism;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physiological;Play;pleiotropism;Population;Population Sizes;Predisposition;Prevalence;programs;Quantitative Trait Loci;Recombinants;Research;Research Personnel;Resistance;Resolution;response;Risk Factors;Role;Sampling;Shapes;Stress;Structure;Study models;success;System;Testing;Time;Tissues;Translating;United States;Variant;Work

PROJECT_TITLE: Natural variation underlying extraordinary lifespan

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BERKELEY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Obesity is a major health problem associated with metabolic syndrome and type II diabetes and the control of adiposity is a top priority in managing these diseases. Promoting thermogenesis may not only help in combating obesity but also in improving glucose/insulin homeostasis. This research is to understand how the main critical protein of thermogenesis is induced to promote thermogenesis in brown fat and may provide new therapeutic targets for obesity/diabetes.

PI_NAMEs: SUL, HEI SOOK  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Adipocytes;adiponectin;Adipose tissue;Adrenergic Agents;Adult;ATAC-seq;Binding;Binding Sites;Biological Assay;Body Temperature;Brown Fat;Cells;Chromatin;Chronic;Cleavage Under Targets and Release Using Nuclease;combat;CRISPR interference;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;crosslink;Defect;Diabetes Mellitus;Disease Management;Energy Metabolism;Enhancers;Epidemic;ETV4 gene;Frequencies;Future;Gene Activation;Gene Expression;Genes;Genetic Transcription;genome-wide;Genomics;Glucose;Goals;Guide RNA;Health;High Fat Diet;histone modification;Histones;Homeostasis;improved;in vivo;Injections;Insulin;Insulin Resistance;KDM1A gene;Leptin deficiency;Libraries;Luciferases;Maintenance;Mediating;Metabolic Diseases;Metabolic syndrome;Mus;Mutation;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity genetics;Organ;overexpression;Oxygen Consumption;Physiological;Production;programs;promoter;Promoter Regions;Proteins;recruit;Reporter;Repression;Research;Role;small hairpin RNA;Technology;Testing;Therapeutic;Thermogenesis;Tissues;transcription factor;Transcriptional Activation;transcriptome sequencing;Upstream Enhancer

PROJECT_TITLE: Enhancer for UCP1 transcription and thermogenesis

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE We have known for 30 years that the 10% of infants born small for gestational age, compared to average for gestational infants, are at increased risk for later life coronary heart disease (CHD) and cardiovascular disease (CVD) mortality. This one-of-a-kind 60-year longitudinal study seeks to understand why and to advance clinical and public health strategies to reduce this increased risk. It will identify and link biomarkers collected during pregnancy (in the 1960s) to sophisticated measures of heart function and disease among 800 adults now ages 60-65.

PI_NAMEs: BUKA, STEPHEN L (contact);EATON, CHARLES B

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Address;adjudication;Adult;Adult Children;Age;Age Years;aged;Barker Hypothesis;Biological Markers;Boston;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Chronic;Clinical;Clinical assessments;cohort;Communities;coronary artery calcium;Coronary heart disease;Data;Development;Diabetes Mellitus;Disease;Disease Outcome;Disease Progression;disorder prevention;Dyslipidemias;Early identification;Early Intervention;Enrollment;Erythropoietin;experience;Family Study;fetal;fetal programming;fetus hypoxia;Fingerprint;follow-up;Functional disorder;Gestational Age;Glucose;Health;Heart;heart disease risk;Heart Diseases;heart function;Hematological Disease;Heterogeneity;High Density Lipoproteins;high risk;Hypertension;Impairment;Individual;Infant;insight;Intervention;Knowledge;late life;Life;life span;Link;Lipids;Longitudinal Studies;Lung;Lung Diseases;Malnutrition;maternal serum;Measures;Metabolic;metabolomics;mortality;Mothers;multidisciplinary;National Heart, Lung, and Blood Institute;New England;nutrient deprivation;Obesity;offspring;Onset of illness;Participant;Perinatal;PGF gene;Placenta;Pregnancy;Pregnant Women;prenatal;Prevention;primary outcome;pro-brain natriuretic peptide (1-76);prospective;Public Health;Publishing;recruit;Risk;Risk Factors;Sampling;screening;secondary outcome;Serum;Serum Markers;Site;Sleep Disorders;Small for Gestational Age Infant;Structure;Subgroup;Third Pregnancy Trimester;Triglycerides;Umbilical cord structure;United States National Institutes of Health;Vascular Endothelial Growth Factor Receptor-1;vasculogenesis;Work

PROJECT_TITLE: Early Developmental Risk for Adult Cardiovascular Disease: High risk Subgroups, Biomarkers, and Mechanisms

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Multiple sclerosis (MS) is an immune-mediated disorder of the central nervous system that affects more than 2 million people worldwide, causes irreversible neurologic disability, and is currently incurable. Focal inflammatory demyelination in the cortex is common in MS and is associated with disability and disability worsening over time, but our understanding of cortical lesions has so far been limited by insensitive in vivo magnetic resonance imaging (MRI) methods. Here we propose to use a combination of advanced, ultra-high field MRI and cutting- edge transcriptomic methods to characterize cortical demyelination and repair in early MS and its impact on the course of disease.

PI_NAMEs: BECK, ERIN SAVNER (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Activated Lymphocyte;Adult;Affect;Area;Blood;Brain;brain magnetic resonance imaging;brain volume;Cells;Central Nervous System;central nervous system demyelinating disorder;Central Nervous System Diseases;Cerebrospinal Fluid;Chemotaxis;Chronic;chronic inflammatory disease;Clinical;Clinical assessments;Clinical Course of Disease;Cognitive;cognitive disability;cognitive testing;cohort;Collection;Data;Demyelinations;Detection;Development;disability;Disease;Evaluation;Flow Cytometry;follow-up;Functional disorder;Future;Goals;Growth;healthy volunteer;Image;imaging modality;Immune;immune activation;Immunologics;Impaired cognition;improved;in vivo;in vivo imaging;Individual;Inflammation;Inflammation Mediators;Inflammatory;insight;Iron;Language;language impairment;Lead;Lesion;Magnetic Resonance Imaging;Measures;Mediating;Meningeal;Methods;Motion;Motor;Motor disability;Multiple Sclerosis;multiple sclerosis patient;Natural History;Neurodegenerative Disorders;Neurological disability;Newly Diagnosed;Participant;Pathology;Pathway interactions;Patients;Pattern;Persons;Phenotype;Physical assessment;physical impairment;physically handicapped;Prevention;Process;Prognosis;Progressive Disease;prospective;Proteomics;recruit;remyelination;repaired;Spinal Cord;T2 weighted imaging;Testing;therapy development;Time;Tissues;transcriptomics;Up-Regulation;Veins;Visualization;white matter;Work;young adult

PROJECT_TITLE: Cortical Demyelination and Repair in Early Multiple Sclerosis.

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: BRONX

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Crimean-Congo hemorrhagic fever virus (CCHFV) causes severe and frequently lethal hemorrhagic disease in humans for which no vaccines or treatments are available. Here, we plan to study and understand how CCHFV hijacks human cells to infect and multiply in them, and how it causes disease in animals and humans.

PI_NAMEs: CHANDRAN, KARTIK  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;Africa;Animals;Antibodies;Antibody-mediated protection;Architecture;Asia;Binding;Biogenesis;Biological Assay;Blood Vessels;Cells;Collaborations;Complement;Complex;Containment;Country;Crimean-Congo Hemorrhagic Fever Virus;Cryoelectron Microscopy;Data;Development;Disease;endothelial dysfunction;Endothelium;Engineering;Environment;Epitope Mapping;Epitopes;Europe;Evolution;FDA approved;Flavivirus;Foundations;Genetic;genetic approach;Genetic study;Glycoproteins;Goals;Hemorrhage;Human;human disease;human monoclonal antibodies;In Vitro;in vivo;Infection;Integration Host Factors;Location;Maps;Mass Spectrum Analysis;Mediating;medical countermeasure;Membrane;membrane assembly;Membrane Proteins;Modeling;Molecular;Molecular Conformation;Monoclonal Antibodies;mouse model;Mutagenesis;mutant;Mutation;Nairovirus;National Institute of Allergy and Infectious Disease;novel;Orthobunyavirus;Pathogenesis;Pathway interactions;Permeability;premature;priority pathogen;protective efficacy;Protein Engineering;Proteolytic Processing;Recombinant Proteins;Recombinants;Research;Resolution;Reverse engineering;Rodent Model;Role;SARS-CoV-2 spike protein;Series;Specificity;Structure;Surface;Testing;tick-borne virus;tissue culture;Toxin;Vaccines;Vesicular stomatitis Indiana virus;Viral;Viral Pathogenesis;Virion;virology;Virus;Virus Assembly;Virus Diseases;virus host interaction;Virus-like particle

PROJECT_TITLE: Reverse-engineering a viral Swiss army knife: Crimean-Congo hemorrhagic fever virus glycoprotein functions in assembly, entry, and in vivo pathogenesis

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BLACKSBURG

ORG_DEPT: ORTHOPEDICS

ORG_NAME: VIRGINIA COLLEGE OF OSTEOPATHIC MEDICINE

ORG_STATE: VA

PHR: PROJECT NARRATIVE This research will contribute to fundamental knowledge regarding the mechanism by which cranial osteopathic manual manipulation (cOMM) enhances fluid flow in the brain and alleviates neurological symptoms after brain injury. Currently, there is a lack of mechanistic research on force-based interventions such as cOMM and there is limited data available on the brain’s response to this innovative treatment.

PI_NAMEs: BROLINSON, PER GUNNAR  (contact)

PROGRAM_OFFICER_NAME: TUTTLE, ALEXANDER H

PROJECT_TERMS: Accounting;Acute;acute symptom;Adverse effects;Affect;Anxiety;Athletic Injuries;Autonomic nervous system;Behavioral;behavioral study;Biological;Biological Models;biophysical properties;blast exposure;Blood flow;Brain;Brain Concussion;Brain Injuries;brain parenchyma;Centers for Disease Control and Prevention (U.S.);Cephalic;cholinergic;Chronic;Clinical;Clinical Data;Clinical Treatment;Cognitive;Cognitive deficits;contrast enhanced;Convection;Coupled;cytokine;Data;Diffusion;Disease;draining lymph node;Edema;Evaluation;Event;Experimental Designs;falls;Female;fluid flow;Foundations;functional disability;Functional disorder;Head;health care service utilization;Hippocampal Formation;Histologic;Image Enhancement;Imaging Techniques;Immune;Impaired cognition;improved;Inflammation;Inflammatory;injured;Injury;injury-related death;innovation;Integrative Medicine;Intercellular Fluid;Intervention;Investigation;Knowledge;Learning;Link;Liquid substance;lymph nodes;Magnetic Resonance Imaging;male;Manuals;Measures;Medical;Medicine;Memory impairment;memory retrieval;Metabolic;Modeling;Molecular Biology Techniques;Motion;Musculoskeletal;National Center for Complementary and Integrative Health;Nerve Degeneration;neural;neurobiological mechanism;Neurobiology;Neurodegenerative Disorders;neuroinflammation;Neurologic;Neurologic Deficit;Neurologic Dysfunctions;Neurologic Symptoms;neuropathology;neuroregulation;neurotransmission;Osteopathic Medicine;Outcome;Pathologic;Pathology;Patients;Pattern;persistent symptom;Phenotype;Physiological;pre-clinical;pre-clinical assessment;Pre-Clinical Model;prevent;psychologic;psychological distress;Publishing;Quality of life;Rattus;Recovery;reduce symptoms;Research;Research Design;response;Risk;Rodent;Sampling;Series;Severities;sex;Signal Transduction;soft tissue;Symptoms;System;TBI treatment;Techniques;Thalamic structure;Therapeutic;Time;Tissues;Traumatic Brain Injury;treatment strategy;vehicular accident;Vertebral column;Vocation;wasting

PROJECT_TITLE: Cranial Osteopathic Manipulative Medicine Enhances Brain Fluid Flow Alleviating Neuroinflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-T (02)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Depression;Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Patient Safety;Precision Medicine;Serious Mental Illness

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative - public health relevance The current approaches to prescribing medication for patients with post-traumatic stress disorder and major depression disorder are inadequate, as clinicians are forced to use a trial-and-error to determine the best course of treatment. It is possible to analyze a patient’s DNA to determine if their metabolism will cause a positive therapeutic response or have serious negative side effects, but current methods are expensive and take multiple weeks to return results. We plan on creating a simpler test that can be carried out in the clinicians office < 1 hour, and while it won’t provide the same breadth of information as the more expensive test, the results are immediate and enhances the chances that the clinician prescribes the correct medication, potentially avoiding adverse effects such as toxicity and ineffective levels.

PI_NAMEs: VENTON, B. JILL (contact)

PROGRAM_OFFICER_NAME: ALVAREZ, RUBEN PAUL

PROJECT_TERMS: adverse drug reaction;Adverse effects;Affect;Algorithms;Alleles;Automation;Biological Assay;Capillary Electrophoresis;Caring;Cessation of life;Chemicals;Chemistry;Clinical;Code;Collection;Communicable Diseases;cost;cost effective;CYP2C19 gene;CYP2D6 gene;Cytochrome a;Cytochrome P450;Data;Databases;design;Detection;Devices;Diagnosis;Disparate;DNA;dosage;Dose;Drug Incompatibility;Drug Prescriptions;Drug Targeting;Endowment;Engineering;Enzymes;Excretory function;Forensic Medicine;Genes;Genetic;genetic analysis;Genetic Variation;Genome;Genotype;Goals;graphical user interface;Heating;Hospitalization;Hour;Human;improved;Individual;inhibitor therapy;innovation;insertion/deletion mutation;insight;instrument;instrumentation;Intervention;Interview;Label;Literature;Liver;Major Depressive Disorder;Malignant Neoplasms;manufacture;Medical;metabolic phenotype;Metabolism;Methodology;Methods;microdevice;microfluidic technology;Microfluidics;Nucleotides;Outcome;oxidation;Pathway interactions;Patient Care;patient response;patient screening;Patients;Performance;Pharmaceutical Preparations;Pharmacogenetics;Pharmacogenomics;Pharmacotherapy;phenome;Phenotype;Physicians;Play;point of care;Point-of-Care Systems;portability;Post-Traumatic Stress Disorders;precision genetics;premature;Prevention;Process;Productivity;Psychiatry;public database;public health relevance;rapid test;Recommendation;Research;research clinical testing;Resistance;response;Role;Sampling;screening;Selective Serotonin Reuptake Inhibitor;Series;side effect;Single Nucleotide Polymorphism;standard of care;Suggestion;Suicide;Summary Reports;Swab;System;Testing;Time;tool;Toxic effect;Treatment outcome;treatment planning;treatment response;United States;Validation;Variant;Work

PROJECT_TITLE: A Portable, Low-Cost, Pont-of-care Microfluidic System for Rapid Pharmacogenomic Screening of Patients with Major Depressive Disorder

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project narrative This project aims to investigate the role of endothelial cell metabolism and cell cycle in the fluid shear stress patterns that determine resistance vs susceptibility to atherosclerosis. We will conduct an extensive, unbiased analysis of the effects of different shear stress patterns on metabolic and metabolomic parameters; will test the role of a piezo1-mitochondrial pathway in susceptibility to atherosclerosis; and will investigate the role of a late G1-arrested state with active Cdk2 in disease, including both in vitro mechanistic studies and in vivo pre-clinical experiments.

PI_NAMEs: SCHWARTZ, MARTIN A (contact)

PROGRAM_OFFICER_NAME: PLAYFORD, MARTIN P

PROJECT_TERMS: African;Aging;Anti-Inflammatory Agents;Antiatherogenic;Antiinflammatory Effect;Area;athero susceptible;atherogenesis;atheroprotective;Atherosclerosis;biological adaptation to stress;Biomechanics;Blood flow;Cardiovascular Diseases;CDK2 gene;Cell Cycle;Cell Physiology;Cell Respiration;cell type;Cells;Cellular Metabolic Process;Communication;Cyclin-Dependent Kinases;Cyclins;cytokine;Cytoplasm;Cytoskeleton;Data;Development;Disease;Disease Pathway;Disease Progression;Disease Resistance;DNA Damage;Endothelial Cells;Endothelium;experimental study;Feedback;G1 Arrest;gain of function;gain of function mutation;Generations;Health;Homeostasis;Hyperglycemia;Hyperlipidemia;In Vitro;in vivo;in vivo evaluation;Inflammation;Inflammatory;inhibitor;Insulin Resistance;Lesion;Link;lipidomics;Liquid substance;loss of function;Mediator;Mesenchymal;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Mitochondria;mutant;new therapeutic target;novel;Nuclear;Pathway interactions;Pattern;Phenotype;Physiological;Piezo 1 ion channel;Play;Population;pre-clinical;Predisposition;Process;Publishing;Regulation;Resistance;response;Risk Factors;Role;shear stress;Signal Transduction;synergism;Testing;Transforming Growth Factor beta;Vascular Endothelium;Work

PROJECT_TITLE: Metabolism and cell cycle as mediators of fluid shear stress effects on vascular endothelium in health and disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Dental, Oral, and Craniofacial Disease;Lung;Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Chronic rhinosinusitis and olfactory dysfunction are clinically impactful and understudied complications of cystic fibrosis in young children; highly effective therapies that aim to correct the defective protein responsible for the clinical manifestations of cystic fibrosis are becoming more widely available. This proposed investigation will characterize chronic rhinosinusitis and olfactory dysfunction in young children with cystic fibrosis and determine the degree to which highly effective therapies improve these complications. Findings from this investigation, which are aligned with cystic fibrosis community research priorities, will inform optimization of both quality of life and overall health, and will highlight the importance of evaluating and managing comorbidities at a young age.

PI_NAMEs: BESWICK, DANIEL M (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Adult;Age;age group;aged;airway inflammation;Anosmia;Antibiotics;Biological;Birth;Body System;Child;children with cystic fibrosis;Chronic;chronic rhinosinusitis;Clinical;Collaborations;Collection;community research;comorbidity;Complication;Control Groups;cranium;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;data sharing;Development;Disease;disease natural history;Early treatment;effective therapy;Eligibility Determination;Endocrine;Enrollment;Ensure;Evaluation;experience;Foundations;Funding;Future;gastrointestinal;Gastrointestinal tract structure;gene therapy;Goals;Growth;Health;Health Status;Impairment;improved;Inferior;Inflammation;instrument;Investigation;Ionizing radiation;Life;Long-Term Effects;Longitudinal Studies;Lung;lung health;Magnetic Resonance Imaging;Matched Group;Mental Depression;Modeling;Morbidity - disease rate;Multicenter Studies;Nasal cavity;neuroepithelium;Neurons;nutrition;Nutritional;Nutritional status;Observational Study;Odors;olfactory bulb;Olfactory dysfunction;Organ;Outcome;Outcome Measure;Outcome Study;Pathway interactions;Persons;Phase;prevent;Process;prospective;Prospective Studies;Proteins;Quality of life;Radiation exposure;Refractory;Research;Research Priority;Resolution;Respiratory Tract Infections;screening;Severities;Sinus;Sinusitis;Site;Smell Perception;Symptom Burden;Techniques;Testing;theories;Time;treatment group;VX-770;Work;Youth

PROJECT_TITLE: Sinus Disease in Young Children with Cystic Fibrosis

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Neural network hyperexcitability caused by impairments in GABAergic inhibition gives rise to epilepsy which currently affects 3.4 million patients in the US. KCC2 is a neuronal chloride transporter critical for the inhibitory action of GABA, and its dysregulations are associated with various brain disorders including epilepsy. Leveraging our previous discovery that drugs inhibiting the FLT3 kinase pathway stimulate KCC2 expression in neurons and strengthen GABAergic inhibition in the brain, our research will establish the functional roles of FLT3 signaling in healthy and epileptic brains, laying the foundation for a novel therapeutic approach to suppress the onset and recurrence of epileptic seizures.

PI_NAMEs: TANG, XIN  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Adult;Affect;autism spectrum disorder;Behavior;behavioral phenotyping;Biochemical;Biological Assay;blood-brain barrier crossing;Brain;Brain Diseases;Chlorides;conditional knockout;Development;Disease;drug development;Drug Targeting;Electrophysiology (science);Epigenetic Process;epigenetic silencing;Epilepsy;epileptic encephalopathies;Epileptogenesis;experimental study;FLT3 gene;FLT3 inhibition;Foundations;gamma-Aminobutyric Acid;Gene Expression;Genes;Gilles de la Tourette syndrome;Glutamates;Health;Hematopoietic Neoplasms;Hippocampus;Impairment;in vivo;inhibitor therapy;Inhibitory Synapse;Intervention;knock-down;Knock-out;Knockout Mice;Knowledge;Link;Mediating;Messenger RNA;Methods;Modification;Molecular;mouse model;Mus;Nervous System;neural;neural circuit;neural network;Neurodevelopmental Disorder;Neurons;Neurophysiology - biologic function;neurotransmission;novel therapeutic intervention;painful neuropathy;Pathogenicity;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phosphorylation;Phosphotransferases;Physiological;Play;Pre-Clinical Model;Predisposition;protein expression;Proteins;Publishing;receptor;Recurrence;Research;response;Rett Syndrome;Role;Schizophrenia;Seizures;Signal Pathway;Signal Transduction;small molecule;symporter;System;Testing;Time;timeline;Variant;Work

PROJECT_TITLE: Molecular pathways that strengthen GABAergic inhibition and reduce seizure susceptibility

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: MD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Existing healthcare data systems lack relevant information to support social interventions: it is difficult to identify individuals with social needs and difficult to facilitate their engagement with social service providers. This project will apply a precision medicine approach to the identification of, and engagement with, Medicaid recipients with social needs. We will help identify and address social needs and shrink disparities in health outcomes across a large, high-risk population while informing the next generation of value-based care paradigms.

PI_NAMEs: STOCKWELL, IAN  (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Accident and Emergency department;Address;Affect;Artificial Intelligence;Automobile Driving;barrier to care;Caring;Characteristics;Child;Chronic;clinical care;Clinical Data;Communities;community based practice;community engagement;Community Health Aides;Community Health Planning;community organizations;Data Collection;data infrastructure;Data Sources;Development;Disabled Persons;disparity gap;disparity reduction;Elderly;ethnic minority;Evaluation;Evidence based practice;Face;Frustration;Geography;Health;health disparity;health equality;Health Food;health information technology;Health Personnel;health plan;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;high risk;high risk population;Housing;improved;Incentives;Income;Individual;Information Systems;Information Technology;Infrastructure;Insurance Carriers;Intervention;Knowledge;Lead;Learning;machine learning model;Managed Care;Maryland;Medicaid;Medical;member;Methods;Modeling;National Institute on Minority Health and Health Disparities;Needs Assessment;next generation;Outcome;outreach services;Patients;Personal Satisfaction;Persons;Population;Positioning Attribute;precision medicine;prevent;process improvement;Protocols documentation;Provider;racial minority;Recommendation;Recurrence;Reporting;Research;Risk;screening program;Services;social;social engagement;social interventions;Social outcome;social service provider;Social support;Social Work;Standardization;success;Support System;System;Techniques;technology platform;Training;Update;Vulnerable Populations;Work

PROJECT_TITLE: The Development, Implementation, and Evaluation of a Social Engagement Support System

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: CAMBRIDGE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Physical expansion of biological samples is a method that has been previously applied to facilitate enzymatic access and perform superresolution imaging. Here, we will apply expansion to de-crowd the nuclear environment, increasing the resolution and multiplexing capabilities of single-cell and spatial epigenomics methods.

PI_NAMEs: BUENROSTRO, JASON DANIEL (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: 3-Dimensional;Acrylamides;Address;Adoption;Aging;Antibodies;ATAC-seq;Bar Codes;Biochemical Reaction;Biological;Biological Assay;Cell Nucleus;Cells;Chemicals;Chromatin;combinatorial;Complex;computerized tools;Concatenated DNA;Crowding;Data;design;Development;Disease;DNA;DNA-Protein Interaction;Encapsulated;Environment;Epigenetic Process;epigenome;epigenomics;Epitopes;experimental study;Face;Gel;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genome sequencing;genomic data;genomic locus;Genomics;Hi-C;Human Development;imaging approach;Imaging Techniques;improved;In Situ;in situ sequencing;indexing;interest;Label;Libraries;Link;link protein;Measurement;Measures;Messenger RNA;Methods;Microfluidic Microchips;Microfluidics;Microscopy;Modality;Modeling;Modernization;Modification;multimodality;multiple omics;multiplexed imaging;nanoscale;novel;Nuclear;Nuclear Proteins;particle;Polymers;Positioning Attribute;programs;Protein Fragment;Proteins;Protocols documentation;Resolution;Sampling;simulation;Structure;superresolution imaging;Techniques;Technology;three dimensional structure;Tissues;Tn5 transposase;tool;transcriptome;ultra high resolution;whole genome;Work

PROJECT_TITLE: Expansion genomics for high-resolution single-cell and spatial epigenomics

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative: The interphotoreceptor matrix (IPM) is an essential extracellular matrix crucial for maintaining vision by connecting neuronal photoreceptor cells with the glial retinal pigment epithelium. Deficiencies in IPM proteins, such as IMPG1 and IMPG2, contribute to blinding diseases like retinitis pigmentosa. This project seeks to enhance public health by elucidating the roles of IMPG1 and IMPG2 in maintaining photoreceptor health, exploring their link to blinding diseases, and evaluating therapeutic strategies for these retinal disorders.

PI_NAMEs: SALIDO, EZEQUIEL MARTIN (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acceleration;Adult;Affect;Age Months;Agrin;Alzheimer's Disease;analog;Apical;Biochemical;Blindness;Cell Death;Childhood;Defect;design;Development;Diffusion;Disease;enteropeptidase;Epilepsy;Extracellular Matrix;gene therapy;Glucose;Goals;Health;Heterozygote;Homeostasis;Homo;Human;human disease;immunological status;Knockout Mice;Lead;Length;Link;Macular degeneration;Messenger RNA;Metabolic;Missense Mutation;Molecular;mouse model;Mus;Mutant Strains Mice;Mutation;Neuroglia;Neurons;Nonsense Codon;novel therapeutics;Nutrient;Onset of illness;Pathology;Patients;Phagocytosis;Phenotype;Photoreceptors;Play;Polysaccharides;prevent;Process;protein protein interaction;Protein Secretion;Protein Truncation;Proteins;Proteoglycan;Proteolysis;Public Health;Research Project Grants;Retina;Retinal Diseases;Retinitis Pigmentosa;Rod;Role;Side;small hairpin RNA;sperm protein;Structure of retinal pigment epithelium;Tertiary Protein Structure;Testing;Therapeutic;therapeutic evaluation;Tissues;Translating;treatment strategy;Vision;visual cycle;wasting;Work

PROJECT_TITLE: Role of Interphotoreceptor Matrix Proteoglycans in Retinal Homeostasis and Retinitis Pigmentosa

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Mental Health;Mental Illness;Pain Research;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Telehealth;Women's Health Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Only one in four depressed cancer patients receives evidence-based treatment for depression. We will test the effect of iCan DepCare, an equity-informed digital, multi-level implementation strategy on uptake of depression treatment in socioeconomically diverse oncology settings.

PI_NAMEs: MOISE, NATHALIE  (contact)

PROGRAM_OFFICER_NAME: RANDHAWA, GURVANEET

PROJECT_TERMS: Address;Adoption;Algorithms;anti-depressive agents;Automobile Driving;barrier to care;Behavioral;behavioral health;Breast Cancer Patient;cancer care;Cancer Fatigue;cancer health disparity;Cancer Patient;cancer recurrence;cancer risk;Caring;chemotherapy;Clinic;Clinical;Clinical Oncology;Cluster randomized trial;Cognitive Therapy;collaborative care;Communication;Communities;Complex;Consolidated Framework for Implementation Research;Consumer Preferences;contextual factors;Continuity of Patient Care;cost;cost effectiveness;Counseling;demographics;Depressed mood;depressed patient;Depression screen;depressive symptoms;digital;digital health;digital tool;Education;Effectiveness;Eligibility Determination;Equity;ethnic disparity;ethnic minority;Ethnic Origin;evidence base;Evidence based treatment;Exercise;experience;Feasibility Studies;Feedback;Focus Groups;Fright;Group Therapy;Guidelines;Health Expenditures;health practice;Healthcare Systems;Home;Hybrids;implementation framework;implementation science;implementation strategy;implementation trial;implementation/effectiveness;improved;indexing;Individual;Information Technology;Infrastructure;Infusion procedures;Insurance;integrated care;Intervention;Knowledge;Leadership;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Marketing;meetings;Mental Depression;Mental Health;Meta-Analysis;Methods;Mindfulness Training;Modeling;Moods;mortality;Navigation System;Oncologist;Oncology;oncology trial;Outcome;Pain;patient engagement;Patient observation;patient-clinician communication;Patients;Pharmaceutical Preparations;physical symptom;preference;primary outcome;Problem Solving;Process;prototype;provider communication;Psyche structure;psychoeducation;Quality of life;Race;racial disparity;racial minority;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recurrence;Resources;screening;Selection for Treatments;Service delivery model;Severities;Signal Transduction;Site;social stigma;Social Work;socioeconomics;System;systematic review;Testing;theories;Time;tool;Training;treatment as usual;treatment guidelines;treatment optimization;Triage;uptake;usability;user centered design

PROJECT_TITLE: Harnessing digital health and equity informed multi-level implementation strategies to promote uptake of depression treatment in cancer settings: iCan DepCare

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Heart failure myocardium exhibits electrophysiologic pathological remodeling that underlies the development of arrhythmias leading to sudden cardiac death. Here we aim to delineate the mechanisms behind KChIP2 transcriptional repression of the stress kinase JNK2 gene and the possible causal role of increased/activated JNK2 to arrhythmia mechanisms and sudden cardiac death onset. The outcomes of this proposal will establish the therapeutic potential of KChIP2 gene transfer and/or JNK2 inhibition as prospective anti-arrhythmia interventions for a translational path toward future arrhythmia therapies in HF patients.

PI_NAMEs: AI, XUN ;DESCHENES, ISABELLE  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Affect;Animal Model;Anti-Arrhythmia Agents;Arrhythmia;ATP2A2;Binding;Biochemistry;Biological Assay;calmodulin-dependent protein kinase II;Cardiac;Cardiomyopathies;Cell Communication;Cell Nucleus;Cells;chromatin remodeling;Complex;confocal imaging;Connexin 43;Coupling;Data;Development;Dilated Cardiomyopathy;Disease;Disease Progression;Dominant-Negative Mutation;Down-Regulation;effective therapy;Electrophysiology (science);Event;Exhibits;Experimental Designs;experimental study;forest;Future;Gap Junctions;Gene Expression;Gene Expression Regulation;gene repression;Gene Transfer;Genes;Genetic Transcription;Guidelines;Heart;Heart failure;Heart Transplantation;Human;Hypertrophy;Immunoprecipitation;Impairment;Implant;Implantable Defibrillators;insight;Intervention;Ion Channel;Kv channel-interacting protein 2;Left ventricular structure;Link;MAPK8 gene;MAPK9 gene;Maps;Modeling;mortality;mouse model;Mus;Myocardial;Myocardium;novel;Optics;Organ Donor;Oryctolagus cuniculus;Outcome;overexpression;patch clamp;Pathogenesis;Pathologic;Pathway interactions;Patients;Persons;Phosphorylation;Phosphotransferases;Pilot Projects;Play;Potassium Channel;Predisposition;Primary Prevention;prospective;Protein Isoforms;Proteins;randomized, clinical trials;Recommendation;Repression;Rodent Model;Role;Sarcoplasmic Reticulum;Secondary Prevention;stress kinase;sudden cardiac death;Survival Rate;Symptoms;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Transcription Repressor;Transcriptional Regulation;Transplant Recipients;United States;Up-Regulation;uptake;Ventricular;Ventricular Arrhythmia;Ventricular Fibrillation;Ventricular Tachycardia;Western Blotting

PROJECT_TITLE: The KChIP2-JNK2 axis as a therapeutic target for sudden cardiac death

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CLEMSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PUBLIC HEALTH RELEVANCE: Cardiovascular disease is the leading cause of death worldwide. The goal for the proposed research is to develop nanowired, hypoimmunogenic hPSC cardiac organoids to provide “off-the- shelf” therapeutics for heart repair.

PI_NAMEs: LIAN, XIAOJUN ;MEI, YING  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Acceleration;Affect;Allogenic;Biocompatible Materials;Cardiac;Cardiac Myocytes;cardiac repair;Cardiovascular Diseases;Cause of Death;CD47 gene;cell type;Cells;Cessation of life;Chemicals;clinical translation;Coculture Techniques;Data;Derivation procedure;Diabetes Mellitus;Dissociation;Electric Conductivity;Endothelial Cells;Engraftment;Female;Fibroblasts;Flow Cytometry;Foundations;Genes;Goals;Graft Survival;Heart;HLA Antigens;Human;human pluripotent stem cell;humanized mouse;Immune;immune activation;Immunocompetent;Immunologic Surveillance;implantation;In Vitro;in vivo;Infarction;innovation;Ischemia;islet;Knock-in;Knock-out;male;mouse model;Mus;Myocardial Infarction;nanowire;Natural Killer Cells;Nude Rats;Organoids;Patients;Persons;Property;public health relevance;Rattus;Recovery;Recovery of Function;Regenerative Medicine;Reperfusion Injury;Research;RNA;Shortening Fraction;Silicon;Stromal Cells;Structure;synergism;T-Lymphocyte;Technology;Testing;Therapeutic;Time;transcriptome;Transplantation;Treatment Efficacy;United States;Validation

PROJECT_TITLE: Nanowired hypoimmunogenic hPSC cardiac organoids for heart repair

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Arthritis;Genetics

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

PHR: Project Narrative Interleukin-17A (IL-17A) plays an important role in autoimmune diseases; however, the limited therapeutic utility of blocking IL-17A in rheumatoid arthritis points to the gaps in understanding its signaling mechanisms. We recently published 14-3-3z-TRAF interaction-mediated novel regulation of IL-17A signaling. This proposed work studies the molecular mechanisms, consequences, and physiological relevance of 14-3-3z-TRAF interactions that will elucidate fundamental knowledge of IL-17A signaling and rheumatoid arthritis.

PI_NAMEs: CHAKRAVARTI, RITU  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Adaptor Signaling Protein;Affect;Animal Model;Animals;Attenuated;Autoimmune Diseases;Binding;Biology;Chronic;Communicable Diseases;Complementary DNA;Complex;CXCL1 gene;cytokine;Data;design;Disease;Exhibits;Fibroblasts;Gene Expression;gene induction;Gene Transfer;Genes;Genetic Transcription;Goals;IL17 gene;Immune;Immunology;Impairment;In Vitro;in vivo;Inflammatory;Inflammatory Arthritis;innovation;insight;Interleukin Activation;interleukin-17E;Interleukins;Investigation;Joints;knockout animal;Knockout Mice;Knowledge;Link;MAP Kinase Gene;Maps;Mediating;Modeling;Molecular;Molecular Chaperones;mouse model;Mus;mutant;novel;Outcome;Pathogenesis;Pathogenicity;Phenotype;Phosphorylation;Physiological;Play;Population;posttranscriptional;Predisposition;Prevention;Protein Biochemistry;Proteins;Publications;Publishing;Rattus;receptor;Receptor Signaling;recruit;Regulation;Research;Rheumatoid Arthritis;Role;Signal Transduction;Specificity;Synovitis;TBK1 gene;Testing;Therapeutic;Tissues;TNF receptor-associated factor 5;TNF Receptor-Associated Factors;TNFSF11 gene;TRAF2 gene;TRAF6 gene;Ubiquitination;Work

PROJECT_TITLE: Determining role of 14-3-3zeta in IL-17A signaling

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative Leukocyte migration into tissue is a key control point in the inflammatory response. Integrin interactions with their endothelial ligands are crucial for this process, yet very little is known about the signaling events downstream of integrins that drive migration. In this proposal, I will investigate the role of a novel mechanical scaffold in triggering integrin signaling events needed for T cell migration, with the ultimate goal of revealing new molecular mechanisms that can be manipulated to alter T cell functions in inflammatory diseases and cancer.

PI_NAMEs: ROY, NATHAN H. (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Actins;Acute;Adoptive Transfer;Affect;Automobile Driving;Binding;Biochemical;Biophysics;Bulla;cell motility;Cell Physiology;Cells;Chronic;combat;Cytoskeletal Modeling;Cytoskeleton;Data;Defect;Disease;disease model;Endothelial Cells;Endothelium;Event;experimental study;Family;fighting;Foundations;Future;Genetic;Goals;graft vs host disease;Guanosine Triphosphate Phosphohydrolases;Immune;immune cell infiltrate;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;inhibitor;insight;Integrin Binding;Integrins;Intercellular adhesion molecule 1;Knowledge;Leukocytes;Ligands;Malignant Neoplasms;mechanical properties;mechanical signal;Mechanics;mechanotransduction;Membrane;migration;Modeling;Molecular;Motility;mutant;Names;novel;pathogen;Pathway interactions;Peripheral;Phosphorylation;Phosphotyrosine;Physiological;Play;Process;Proliferating;protein protein interaction;Proteins;response;rho;rho GTP-Binding Proteins;Role;scaffold;Scaffolding Protein;Signal Transduction;Site;Solid Neoplasm;Structure;System;T-Cell Activation;T-Lymphocyte;Testing;tissue repair;Tissues;Tyrosine Phosphorylation;Work

PROJECT_TITLE: Defining CasL as an Orchestrator of T cell Migration

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Lung;Precision Medicine;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE ANCA-associated vasculitis (AAV) is a relapsing rheumatologic disease characterized by inflammation of multiple organ systems, including the sinuses and nose. This study will examine the molecules and symptoms related to sinonasal disease as well as other factors that predict development of relapse in AAV. Completion of this work may lead to novel biomarkers and therapies which prevent relapse, minimize unnecessary exposure to long-term immunosuppressive treatments, and improve the quality of life in patients with AAV.

PI_NAMEs: RHEE, RENNIE  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: 16S ribosomal RNA sequencing;Airway Disease;ANCA vasculitis;Area;Autoantibodies;Autoimmune Responses;Bacteria;biobank;Biological;Biological Markers;Biological Process;Biology;Body System;Candidate Disease Gene;chronic rhinosinusitis;Clinical;Clinical Data;clinical heterogeneity;clinical predictors;clinical remission;cohort;Collection;Cytoplasm;Data;Data Reporting;Data Set;Decision Making;Dedications;Development;differential expression;Dimensions;Disease;Disease Progression;Disease remission;dysbiosis;Epithelium;Event;Exposure to;Flare;Future;Gene Expression;Genetic Transcription;Goals;high risk;high throughput technology;High-Throughput Nucleotide Sequencing;Immunosuppressive Agents;improved;Inflammation;Inflammatory;insight;Investigation;Kidney;Knowledge;Longitudinal cohort study;Lower respiratory tract structure;Machine Learning;Measures;microbial;Molecular;Molecular Profiling;Morbidity - disease rate;Mucous body substance;Multiomic Data;multiple omics;Natural regeneration;neutrophil;new therapeutic target;Nose;novel;novel marker;novel therapeutics;Organ;Outcome;Outcome Measure;Participant;Pathway interactions;patient engagement;Patient Outcomes Assessments;patient subsets;Patients;Pattern;Predictive Factor;predictive modeling;Process;Prognostic Marker;prospective;Quality of life;recruit;Recurrent disease;Relapse;relapse prediction;relapse prevention;relapse risk;Reporting;Research;Respiratory Signs and Symptoms;Rheumatism;Sampling;Sinus;Subgroup;Symptom Burden;Symptoms;Systemic disease;Testing;Therapeutic immunosuppression;Training;transcriptomics;Upper respiratory tract;Vasculitis;Visit;Work

PROJECT_TITLE: Molecular and clinical predictors of relapse in ANCA-associated vasculitis

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Project Narrative Immunotherapies with genetically engineered T lymphocytes are successful in controlling the growth and spread of blood cancers but are not effective against solid cancers. We will test the hypothesis that oxidative stress-induced molecular changes in these T cells reduce their ability to kill cancer cells. Our goal is to develop a new version of engineered T cells with reduced stress-induced molecular changes to improve T cell function and therapeutic efficacy against solid cancers.

PI_NAMEs: MIN, IRENE M. (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Address;Antigen Targeting;Area;B lymphoid malignancy;B-Lymphocytes;Binding Proteins;biological adaptation to stress;Blocking Antibodies;cancer cell;cancer clinical trial;cancer infiltrating T cells;Cancer Model;Cancer Patient;cancer therapy;cell growth;Cell Lineage;Cell Physiology;Cells;Cellular biology;Cellular immunotherapy;chimeric antigen receptor;Chronic;Clinical;cytokine;Cytoplasm;cytotoxicity;Development;Down-Regulation;Effector Cell;engineered T cells;Engineering;Epigenetic Process;exhaust;exhaustion;Family;Fluorescence;Functional disorder;functional improvement;G3BP1 gene;Genes;Genetic Engineering;Goals;Growth;Hematopoietic Neoplasms;high reward;high risk;Immune;immune checkpoint;immune checkpoint blockade;Immunotherapy;improved;In Vitro;in vivo;Infiltration;innovation;insight;Intervention;knock-down;Link;Longevity;Lytic;Maintenance;Malignant Neoplasms;Measures;Messenger RNA;Metabolic;Metabolic stress;Molecular;mouse model;mRNA Translation;neoplastic cell;Neurodegenerative Disorders;novel;Outcomes Research;overexpression;Oxidative Stress Induction;Pathway interactions;Patients;Phenotype;Process;programmed cell death protein 1;Proteins;ras GTPase-Activating Proteins;Receptor Activation;receptor function;Receptor Signaling;Regulator Genes;Reporter;response;RNA-Binding Proteins;Role;Signal Transduction;Signaling Molecule;Solid;Solid Neoplasm;Stress;stress granule;stress reduction;success;T cell therapy;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapy development;Thyroid Gland;Toxic effect;Translational Regulation;Translational Repression;Translations;Treatment Efficacy;tumor

PROJECT_TITLE: Targeting metabolic stress response to improve CAR-T cell efficacy.

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (M1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE Precision Medicine has now been firmly incorporated into the routine standard-of-care in many medical specialties, in stark contrast with Psychiatry where quantitative predictors that guide clinical decision-making remain extremely limited. Our proposed studies aim to advance the goals of Precision Psychiatry by using artificial intelligence to build clinical outcome predictors of psychosis through integration of electronic health records, dimensional phenotyping, and genetic information, in addition to exploring the psychosocial impact on patients and clinicians. Our long-term goal is to advance the tools available for personalized approaches to diagnosis, treatment, and prognosis in mental health.

PI_NAMEs: LENCZ, TODD  (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Address;Antipsychotic Agents;Artificial Intelligence;Attitude;biobank;cardiometabolism;Classification;CLIA certified;Clinical;clinical decision-making;clinical implementation;clinical practice;clinical predictive model;clinical predictors;clinical subtypes;Code;Cognition;cohort;comorbidity;Computer Analysis;Consensus;Consent;Copy Number Polymorphism;Data;Data Analytics;Data Collection;Database Management Systems;Databases;Diabetes Mellitus;diabetes risk;Diagnosis;Diagnostic;Dimensions;Disease;DNA;Electronic Health Record;emotional reaction;Ethics;experience;Future;Genetic;genetic analysis;Genetic Counseling;genetic information;genome sequencing;genomic data;Goals;Impairment;improved;Individual;individual patient;individualized medicine;Institutionalization;Insurance;Interview;Knowledge;Life;long term hospitalization;Machine Learning;Medicaid;Medical;medical specialties;Medicine;meetings;Mental Health;Methods;model building;Modeling;Monitor;mortality;multidisciplinary;Nature;New York;novel;Outcome;outcome prediction;Pathogenicity;Patient Recruitments;patient subsets;Patients;Perception;personalized approach;Persons;Pharmacological Treatment;Phenotype;phenotypic data;Population;Population Database;precision medicine;predict clinical outcome;predictive modeling;preventive intervention;Prognosis;prognostic;prospective;Psychiatry;Psychoses;psychosocial;Public Health;rare variant;Recovery;recruit;Refractory;Research;Resistance;Resource Allocation;Risk;Sampling;Schizophrenia;Services;severe mental illness;Severity of illness;side effect;Site;social health determinants;standard of care;Study models;Surveys;System;tool;treatment optimization;treatment planning;treatment response;Untranslated RNA;Validation;Variant;whole genome

PROJECT_TITLE: 4/5-Clinical Outcome Prediction of Psychosis from EHRs (COPPER)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-E (60)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: HERSHEY

ORG_DEPT: SURGERY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative Bacterial intracellular nucleotide second messenger signaling plays an important role in biofilm development. The project proposes to develop small molecules and tether these molecules on polymeric biomaterial surfaces so that small molecules can interfere with nucleotide signaling pathways and interrupt biofilm formation and growth on biomaterial surfaces, and will increase the efficacy of antibiotics against biofilm bacteria in vitro and in vivo.

PI_NAMEs: XU, LICHONG  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acceleration;Address;Animals;Anti-Bacterial Agents;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Bacterial Adhesion;Basic Science;Biocompatible Materials;biomaterial compatibility;Catheters;Childhood;Clinical;clinically relevant;Derivation procedure;Development;Devices;Effectiveness;effectiveness evaluation;Environment;experimental study;Goals;Growth;hemocompatibility;Implant;Implantable venous access port;improved;In Vitro;in vivo;Infection;Interruption;Left;Materials Testing;Medical Device;medical implant;Methods;microbial;Microbial Biofilms;Modeling;Modification;Molecular;Monitor;Names;novel strategies;Nucleotides;pathogenic bacteria;Pathogenicity;Play;polydimethylsiloxane;Polymers;Polyurethanes;preclinical study;preclinical trial;Predisposition;Property;Pyrazoles;Rattus;Research Priority;response;Role;Scheme;Second Messenger Systems;Signal Pathway;Signal Transduction;Silicones;small molecule;subcutaneous;success;Surface;Techniques;Testing;Time;Tissues;transcriptome sequencing;Treatment Efficacy;Venous;Work

PROJECT_TITLE: Antimicrobial Biomaterials that Interfere with Bacterial Nucleotide Messenger Signaling


ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: Narrative Lupus patients have dysfunction of skin lymphatic vessels that bring signals from skin to immune tissues, but the underlying cause is not well understood. This project dissects how skin immune cells can regulate the lymphatic vessels to promote a healthy immune system and improve morbidity in lupus.

PI_NAMEs: LU, THERESA T. (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Adult;Age;Antigens;Apoptosis;Autoantibodies;Autoimmunity;B-Lymphocytes;Binding;Catabolism;Cell Count;Cell Physiology;Cell surface;Cells;Clip;Coculture Techniques;Contact hypersensitivity;Cutaneous;Data;Dendritic Cells;density;Dermal;Dermis;Development;Disease;Disintegrins;Drainage procedure;draining lymph node;Endothelial Cells;Epidermal Growth Factor Receptor;Epidermis;experimental study;exposed human population;Failure;Flare;Functional disorder;Goals;Heparitin Sulfate;Human;Immune;Immune system;Immunity;improved;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Intercellular Fluid;keratinocyte;Langerhans cell;langerin;Lead;Licensing;Ligands;Link;Lupus;Lupus Nephritis;lymph flow;lymph nodes;Lymphatic;lymphatic development;lymphatic drainage;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic function;lymphatic vessel;Macrophage;Mediating;Membrane;Messenger RNA;Metabolic;Metalloproteases;migration;Modeling;Morbidity - disease rate;Mus;Myelogenous;Patients;PGF gene;Phenotype;Photosensitivity;postnatal;postnatal development;programs;Regulation;response;Role;Shapes;Signal Transduction;Skin;skin lesion;sulfotransferase;systemic autoimmunity;Systemic disease;Systemic Lupus Erythematosus;T cell response;T-Lymphocyte;Testing;therapeutic target;Time;Tissues;Tryptophan;Tryptophan 2,3 Dioxygenase;UV induced;UV Radiation Exposure;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factors;VEGFC gene

PROJECT_TITLE: Langerhans cells and lymphatic regulation in immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-V (02)]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Nutrition;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Fasting interventions have numerous health benefits, but the underlying molecular mechanism remains less explored. Here we focus on lysosomes, a dynamic signaling organelle that regulates cellular metabolism, protein homeostasis, and metabolic adaptation – using the mammalian intestine as a paradigm, we will investigate how lysosomes maintain intestinal stem cells and fuel tumorigenesis. Collectively, the goal of this proposal is to leverage novel genetic and biochemical tools to uncover the downstream molecular effectors of lysosome biology, which may have direct implications in developing stem cell regeneration and anti-tumor therapies to improve human health.

PI_NAMEs: YILMAZ, OMER  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: adenoma;Adopted;Automobile Driving;Autophagocytosis;biochemical tools;Biogenesis;Biological Process;Biology;cancer type;Cell Maintenance;cell type;Cells;chemotherapy;Communication;Data;detection of nutrient;Energy-Generating Resources;Fasting;fatty acid oxidation;Fatty Acids;gastrointestinal transplantation;Genes;Genetic;Genetic Transcription;Goals;Growth;Health;Health Benefit;Homeostasis;Human;improved;in vivo;inhibition of autophagy;Injury;insight;Intermittent fasting;Intervention;intestinal adenoma;intestinal homeostasis;Intestinal Neoplasms;intestinal tumorigenesis;Intestines;Knock-out;Knowledge;Lysosomes;Malignant Neoplasms;Maps;Mediating;Metabolic;Metabolism;metabolomics;Methods;Mitochondria;Modeling;Molecular;mutant;novel;Nutrient;Nutrient availability;Oncogenic;Organelles;Pathway interactions;Peroxisome Proliferator-Activated Receptors;Phenotype;Physiological;Physiology;Play;Primary Neoplasm;Proteins;Proteomics;proteostasis;Publishing;Regimen;Regulation;repaired;Research;response;Role;Signal Transduction;Site;stem cell function;stem cell niche;stem cell self renewal;stem cells;synergism;Techniques;Testing;TFE3 gene;therapy development;tissue stem cells;Tissues;transcription factor;transplant model;tumor;Tumor Burden;tumor growth;tumor initiation;tumor progression;tumorigenesis

PROJECT_TITLE: The lysosomal fasting response in intestinal stem cells and cancer

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Aging;Estrogen;Genetics;Human Genome;Osteoporosis;Women's Health Research

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE Women are disproportionally affected by osteoporosis and low bone mass, yet non-estrogen-based sex-specific therapeutic modalities have not been explored. We propose that a X-chromosome-linked gene, KDM5C, contributes to sex differences in bone by regulating bone homeostasis and formation. The successful completion of this study will provide conceptual advances of the genetic mechanisms driving sex-differences in bone homeostasis and disease-associated bone loss.

PI_NAMEs: KRAWCZYK, CONNIE ;YANG, TAO  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Address;Affect;Age;age related;arm;ATAC-seq;Automobile Driving;Bioenergetics;Biology;bone;bone health;bone loss;Bone Marrow;bone mass;cancer risk;Cell Lineage;Cell Physiology;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Coculture Techniques;Communication;Data Analyses;demethylation;Disease;Disparity;Disproportionately impacts women;Energy Metabolism;Enzymes;Epigenetic Process;epigenetic profiling;Estrogen deficiency;Estrogen Replacement Therapy;Female;Gene Expression;Gene Silencing;Genes;Genetic;Genetic study;Genetic Transcription;genomic profiling;Goals;Gonadal Steroid Hormones;Growth Factor;Hematopoietic;Histones;Homeostasis;Immunology;improved;Inflammation;Inflammatory;inflammatory bone loss;Intrinsic factor;Knock-out;Link;Lysine;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;mitochondrial metabolism;Modality;Modeling;Molecular;monocyte;mouse genetics;mouse model;Mus;Mutation;Myelogenous;Myeloid Cells;novel therapeutic intervention;Osteoblasts;osteoclast progenitor;osteoclastogenesis;Osteoclasts;Osteogenesis;osteogenic;Osteoporosis;paracrine;Pathology;Pathway interactions;pharmacologic;Predisposition;prevent;programs;Regulation;Regulatory Element;Research;response;sex;Sex Bias;Sex Chromosomes;Sex Differences;sexual dimorphism;Signal Transduction;skeletal;small molecule inhibitor;System;Testing;Therapeutic;therapeutic development;TNFSF11 gene;transcriptome sequencing;Treatment outcome;Woman;women's treatment;Work;X Chromosome

PROJECT_TITLE: Sexually dimorphic regulation of bone mass by the X-linked histone modifier KDM5C

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Complementary and Integrative Health;Depression;Disability Research;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Stroke

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Stroke survivors typically experience varying degrees of neuropsychiatric impairments after injury, including post- stroke depression (PSD). We have strong supporting data showing that both stroke and aging lead to a reduction in taurine and oxytocin levels, loss of oxytocin leads to a depressive phenotype in mice, and we have also found that plasma taurine and oxytocin levels decline in stroke patients and correlate with depressive symptoms in stroke patients. This project will examine how age-associated reduction of taurine and OXT signaling contributes to microglial activation, the development of PSD, and impaired functional recovery after an induced ischemic stroke in aged mice.

PI_NAMEs: TEIXEIRA, ANTONIO LUCIO;VENNA, VENUGOPAL REDDY  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: acute care;Adult;Affect;age related;aged;Aging;aging brain;aging population;Amino Acids;Attenuated;Behavior;behavioral outcome;Blood;Bone Marrow;Brain;Brain Injuries;Calcium;cardiovascular health;Cells;Chimera organism;Chronic;Clinical;Cognition;CSF1R gene;cytokine;Data;depressive behavior;depressive symptoms;Development;Diet;disability;drinking water;efficacious treatment;Encephalitis;experience;Female;Functional disorder;Functional impairment;functional improvement;Genetic Models;glial activation;glial cell development;Glycine;high risk;Histologic;Homeostasis;Hormones;Hour;Human;Immune;Impairment;improved;Individual;Infarction;Infiltration;Inflammation;inhibitor;Injury;Ischemic Stroke;juvenile animal;Knock-out;Knockout Mice;Lead;Learning;Literature;Maintenance;male;Marrow;Mediating;Memory;men;Mental Depression;Microglia;Middle Cerebral Artery Occlusion;Molecular;monocyte;Morphology;mortality;mortality risk;motor disorder;Mus;neural;neurogenesis;neuroinflammation;neuron loss;Neurons;Neuropeptides;neuropsychiatric disorder;neuropsychiatry;neurotransmission;Neurotransmitters;novel;old mice;Older Population;Osmosis;Oxytocin;Oxytocin Receptor;Patients;Peripheral;Phagocytes;pharmacologic;Phenotype;Physiological;Plasma;post stroke;post stroke depression;prevent;Pump;Quality of life;receptor;Receptor Signaling;reconstitution;Recovery;Recovery of Function;Recurrence;Regulation;Role;Severities;sex;sham surgery;Signal Transduction;Social Behavior;Stress;Stroke;stroke patient;stroke recovery;stroke survivor;stroke therapy;Supplementation;System;Taurine;Testing;Tissues;tool;translational potential;Wild Type Mouse;Woman

PROJECT_TITLE: Deciphering Molecular Mechanisms of Post-Stroke Depression in Aged Mice

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: New therapies are needed for the treatment of obesity and obesity-related conditions like type II diabetes that address core limitations of GLP-1-based therapeutics. In this application we will investigate the activity states of the brain’s endogenous GLP-1 system in diet-based models of obesity, a major gap in knowledge. Further, we will investigate how dysregulation of the brain’s GLP-1 system contributes to obesity pathogenesis and whether elevation of the activity state of this system is a tractable treatment strategy for obesity using laboratory mice, behavior, and neural circuit techniques.

PI_NAMEs: HARDAWAY, JAMES ANDREW (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Adult;Agonist;Anatomy;Animals;Behavior;blood glucose regulation;Body Weight;Body Weight decreased;Brain;Brain region;Chronic;combat;Consumption;Custom;Data;Desire for food;Development;Diet;diet-induced obesity;Dose;Eating;Electrophysiology (science);Energy Intake;experimental study;Exposure to;feeding;Fiber;Functional disorder;Functional impairment;gastrointestinal;Genes;Genetic;GLP-I receptor;glucagon-like peptide 1;High Fat Diet;Hypothalamic structure;Impairment;in vivo;Individual;insight;Intervention;Knowledge;Laboratory mice;Ligands;liraglutide;Maps;Measures;Mediating;Methodology;Modeling;Motivation;multidisciplinary;neural circuit;neuronal circuitry;Neurons;neurotransmission;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nucleus solitarius;obese person;Obesity;obesity treatment;obesogenic;Optical Methods;optogenetics;Output;paraventricular nucleus;Pathogenesis;Pathologic;Pathway interactions;Patients;Peripheral;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Photometry;Public Health;reduced food intake;Reducing diet;Research;Role;side effect;Source;Stimulus;System;Techniques;Testing;Therapeutic;tool;Transgenic Mice;treatment strategy;United States;Viral;Work

PROJECT_TITLE: Pathophysiological mechanisms in the brain's endogenous glucagon-like peptide 1 system mediated by obesogenic diets

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE:  Acute Respiratory Distress Syndrome (ARDS) is a devastating illness most commonly caused by viral infections, and Influenza-A virus (IAV) alone accounts for 300,000-500,000 annual deaths worldwide. Our strong and exciting preliminary data support the hypothesis that epithelial and endothelial TREK-1 potassium channels are downregulated in ARDS lungs, and this injurious process can be counteracted by pharmacological activation of the subset of residual TREK-1 channels with newly-developed compounds. In this proposal we will explore the potential of TREK-1 channels as novel targets against IAV-induced ARDS by establishing (i) the importance of ARDS-induced TREK-1 deficiency in the development of lung injury, (ii) the potential of TREK-1 enhancement as a novel protective strategy, and (iii) the molecular signaling mechanisms underlying TREK-1 protection to facilitate future rational drug design.

PI_NAMEs: SCHWINGSHACKL, ANDREAS  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Acceleration;Acute Respiratory Distress Syndrome;AGTR2 gene;Alveolar;alveolar epithelium;Awareness;Biochemical;Biological Assay;Bioreactors;Blood capillaries;Cell membrane;cell type;Cells;Cessation of life;Clinical;clinically relevant;Coculture Techniques;Critical Care;cytokine;Data;Death Rate;Development;Down's Syndrome;Down-Regulation;Drug Design;Electrophysiology (science);Endothelial Cells;Endothelium;Epithelial Cells;epithelial Na+ channel;Epithelium;Event;Functional disorder;Future;gain of function;Genetic;Histologic;Human;Hyperoxia;hyperoxia induced lung injury;Image;improved;improved outcome;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;Influenza A virus;innovation;Intervention;K ATPase;Knockout Mice;Knowledge;Laboratories;loss of function;Lung;lung development;lung injury;Measures;Mechanical ventilation;Mediating;Medicine;Membrane Potentials;Microfluidics;Modeling;Molecular;Molecular Target;Morphology;mouse model;Mus;new therapeutic target;next generation;novel;novel therapeutic intervention;Outcome;overexpression;patch clamp;Pathway interactions;Patient-Focused Outcomes;pharmacologic;Physiological;Potassium Channel;potassium channel protein TREK-1;precision medicine;prevent;Process;protective effect;protein protein interaction;Research;Residual state;Role;Signal Transduction;Stretching;Structure of parenchyma of lung;success;targeted treatment;Testing;Therapeutic;Tidal Volume;tool;Virus Diseases;voltage

PROJECT_TITLE: The Role of TREK-1 potassium channels in ARDS

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The goal of this project is to study the mechanistic role of oogenic JNK in regulating DNA damage response and apoptosis-related signaling in the oocytes of primordial follicles following treatment with gonadotoxic anti-cancer agents such as doxorubicin. This research is critically important for us to identify the molecular mechanisms of chemotherapy-induced primary ovarian insufficiency (POI) and infertility and the development of therapeutic targets to preserve young female cancer patients’ ovarian reserve, fertility, and ovarian endocrine functions.

PI_NAMEs: KIM, SO-YOUN ;XIAO, SHUO  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Affect;Alleles;anti-cancer;Antineoplastic Agents;Antral;Apoptosis;Apoptotic;Awareness;Birth;cancer cell;Cancer Patient;cancer survival;Cancer Survivor;cancer therapy;cancer type;CBFbeta-MYH11 fusion protein;Cell Survival;cell type;Cells;Cessation of life;Chemicals;chemotherapeutic agent;chemotherapy;Cisplatin;clinically relevant;cohort;Cyclophosphamide;Data;Disease;DNA Damage;Dose;Doxorubicin;druggable target;efficacy evaluation;Endocrine;Endocrine System Diseases;Family;Female;Fertility;Gene Modified;Genes;Genetic;Germ Cells;Goals;Gonadal structure;Health;Hormone secretion;Infertility;Inflammation;inhibitor;JUN gene;kinase inhibitor;Knock-in;leukemia;Leukemic Cell;life span;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;MAPK8 gene;member;Menopause;Mitogen-Activated Protein Kinases;Molecular;mouse model;Nature;Obesity;offspring;Oncogenic;Oocytes;Ovarian;ovarian reserve;Ovary;Ovulation;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Premature Menopause;preservation;prevent;primary ovarian insufficiency;Primordial Follicle;Protein Isoforms;Quality of life;Reproduction;reproductive;reproductive outcome;Research;response;Risk;Role;side effect;Signal Transduction;Somatic Cell;SP600125;Stimulus;Stress;stressor;Survival Rate;targeted cancer therapy;Testing;Therapeutic;therapeutic development;therapeutic target;TP53 gene;transcription factor;transcriptomics;ultraviolet irradiation;Wild Type Mouse

PROJECT_TITLE: Oogenic JNK in gonadotoxic chemotherapy-induced primary ovarian insufficiency

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Maternal Health;Pregnancy;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Over 1 million pregnant patients per year in the US undergo induction of labor with oxytocin. Despite widespread use of this medication, we have a limited understanding of how oxytocin should be dosed and how the uterus should contract in response to oxytocin to achieve the ultimate goal of cervical dilation and labor progression. We propose a clinical and translational study investigating the physiologic and functional response to exogenous oxytocin by placing universal intrauterine pressure catheters in patients undergoing labor induction to determine contraction parameters predictive of success and assessing serial maternal serum oxytocin levels and myometrial oxytocin receptor function in response to oxytocin dosing.

PI_NAMEs: FROLOVA, ANTONINA I;RAGHURAMAN, NANDINI  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Accounting;Affect;American College of Obstetricians and Gynecologists;Area Under Curve;Blood;Catheters;Cell membrane;Cervical;Cesarean section;Clinical Research;Contracts;Data;Discipline of obstetrics;Dose;Drug usage;Exposure to;Failure;fetal;First Labor Stage;Frequencies;Goals;Hemorrhage;Hormones;Hour;improved;Individual Differences;Induced Labor;Infusion procedures;Lead;maternal morbidity;maternal serum;Measures;Morbidity - disease rate;mRNA Expression;Myometrial;myometrium;Neonatal;neonatal morbidity;novel strategies;Oxytocin;Oxytocin Receptor;Pathway interactions;Patients;Pharmaceutical Preparations;Physiological;predictive modeling;pregnant;pressure;prospective;Prospective, cohort study;protein expression;Publishing;receptor function;Recommendation;recruit;response;Risk;Sampling;Schedule;Serum;Smooth Muscle;standard of care;success;Testing;Therapeutic Index;Time;Titrations;translational study;Uterine Contraction;Uterus;Variant;Work

PROJECT_TITLE: Oxytocin for induction of labor: understanding goals and mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE  Results from this study will inform the suitability of VAChT as a candidate biomarker for severity of schizophrenia. This would be applicable to measuring severity of psychotic or cognitive deficits in patients with schizophrenia, and may be useful in diagnostic subtyping of patients with cholinergic system alterations whose symptoms could be responsive to cholinergic-modulating treatments. The data gleaned from this study will also be critical information in further elucidating underlying pathophysiology of symptoms of schizophrenia and in guiding future studies of treatment efficacy and therapeutics development.

PI_NAMEs: WEINSTEIN, JODI JAY (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: acetylcholine receptor agonist;acetylcholine transporter;Address;Affect;Antipsychotic Agents;Back;Behavior;Binding;Biological;biomarker development;Brain;Brain region;candidate marker;cholinergic;Clinical;Clinical Pathology;Clinical Research;Cognitive;Cognitive deficits;cognitive function;cohort;Complex;Data;density;Development;Diagnosis;Diagnostic;diagnostic biomarker;Disabling;Dissection;Dopamine D2 Receptor;dopamine system;Functional disorder;Future;Glean;Hippocampus;Impaired cognition;improved;in vivo;Laboratories;Letters;Light;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Medical;Memory impairment;Modeling;Muscarinic Agonists;Muscarinics;neocortical;Neurobiology;Neurocognition;Neurocognitive;Neurotransmitters;novel;novel diagnostics;novel therapeutics;Pathogenesis;Pathway interactions;patient subsets;Patients;Performance;Pharmaceutical Preparations;Pharmacological Treatment;phase III trial;Positron-Emission Tomography;pre-clinical research;Precision therapeutics;presynaptic;Property;Psychoses;psychotic;psychotic symptoms;radiotracer;Reporting;Sampling;Schizophrenia;Severities;Severity of illness;Short-Term Memory;side effect;Signal Transduction;Subgroup;Symptoms;System;targeted agent;Targeted Research;Testing;Thalamic structure;Therapeutic;Therapeutic Agents;therapeutic biomarker;therapeutic development;therapeutic target;Time;tool development;transmission process;Treatment Efficacy;Work;xanomeline

PROJECT_TITLE: Elucidating Cholinergic Relationships with Psychosis And Cognitive Deficits in Schizophrenia

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Despite a multi-modal standard of care treatment approach including radiation therapy, chemotherapy, and surgical resection, the outcome remains poor for pediatric high-grade gliomas necessitating the development of new therapies. We have previously established an FDA IND- approved personalized adoptive cellular therapy (ACT) platform utilizing total tumor RNA-pulsed dendritic cells (DCs) to expand polyclonal tumor-specific T cells for the treatment of invasive and refractory brain cancers. In this proposal, we will explore a superior approach utilizing the identification and selective amplification of patients’ tumor-specific antigens and uniquely identifying, sorting, and expanding responding tumor-specific T cells for use in ACT to improve the eradication of invasive HGG before pursuing an early phase human clinical trial.

PI_NAMEs: MITCHELL, DUANE A. (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Adolescent and Young Adult;Adoptive Cell Transfers;Affect;Algorithms;Antigen Targeting;Antigen-Presenting Cells;Antigens;Atypical lymphocyte;autoimmune toxicity;Biological Markers;Brain Neoplasms;Brain Stem Glioma;Categories;Cellular Membrane;Central Nervous System Neoplasms;Cessation of life;chemotherapy;Child;Childhood Brain Neoplasm;childhood cancer mortality;Childhood Glioma;Clinical;Clinical Data;clinical efficacy;Clinical Trials;Clone Cells;comorbidity;Complex;Computational algorithm;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Development;Diffuse intrinsic pontine glioma;Disease;Disease remission;effective therapy;Engraftment;Excision;FDA approved;first-in-human;Frequencies;Generations;Genes;Glioma;Heterogeneity;Human;Immunogenomics;Immunologics;Immunotherapy;improved;In Vitro;in vivo;Inflammatory;innovation;Investigational Drugs;Investigational New Drug Application;Lymphocyte;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;Medulloblastoma;Methodology;Modality;Multi-Institutional Clinical Trial;multimodality;neoantigens;Newly Diagnosed;next generation;novel;novel therapeutics;Operative Surgical Procedures;Outcome;overexpression;Pathway interactions;patient variability;Patients;pediatric patients;peripheral blood;personalized immunotherapy;Phase;Phase I Clinical Trials;phase I trial;Phase I/II Clinical Trial;Physiologic pulse;Physiological Processes;Population;pre-clinical;Pre-Clinical Model;preclinical development;preclinical study;prediction algorithm;Productivity;prospective;Radiation therapy;radiological imaging;Recurrence;Refractory;Resected;Resistance;response;RNA;Safety;Sorting;Specimen;standard of care;Synapses;T cell response;T cell therapy;T memory cell;T-Cell Receptor;T-Lymphocyte;targeted treatment;Toxic effect;treatment response;tumor;Tumor Antigens;Tumor Expansion;tumor heterogeneity

PROJECT_TITLE: Addressing tumor heterogeneity in pediatric gliomas with precision adoptive T cell therapy

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: LINCOLN

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE This project aims to combat childhood obesity, a pressing public health concern, by focusing on early childhood nutrition habits in rural areas. Rural children are more likely to become obese, making it crucial to promote healthy eating habits in rural family childcare homes (FCCHs). This project will evaluate the “EAT for Prevention” program's ability to empower FCCH providers in rural communities to implement evidence-based practices that improve children's diets and overall health, ultimately contributing to better public health outcomes.

PI_NAMEs: DEV, DIPTI ASHOK (contact)

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: 5 year old;acceptability and feasibility;Address;Attention;attentional control;Attitude;Body mass index;Caregivers;Carotenoids;Characteristics;Child;Child Care;Child Support;Chronic Disease;Climate;Cluster randomized trial;combat;community engagement;comparison control;Competence;Consumption;Control Groups;Cues;diabetes risk;Diet;Diet Habits;dietary;Dietary intake;early childhood;Eating Behavior;Educational process of instructing;Effectiveness;effectiveness evaluation;Emotional;empowerment;Enrollment;Evidence based practice;Family;Feedback;feeding;follow-up;Food;Food Assistance Programs;Fostering;fruits and vegetables;Goals;Habits;Health;Health Food;Healthy Eating;Height;Hunger;improved;indexing;Intake;Knowledge;Low income;lower income families;Measures;Mediating;Mediator;meter;Mind;model building;Modeling;Nebraska;novel;nutrition;Obesity;obesity in children;obesity prevention;Outcome;patient home care;pilot test;Play;Policies;Positive Reinforcements;preference;Prevention;Prevention approach;prevention effectiveness;Prevention program;primary outcome;Process;programs;Provider;Public Health;Publishing;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Research;Resources;Role;role model;Rural;rural America;rural area;Rural Community;rural families;rural setting;secondary outcome;Self Determination;Signal Transduction;skills;Skin;socioeconomic disadvantage;success;Surveys;System;Testing;theories;Training;Weight;Work

PROJECT_TITLE: Effectiveness of a Multilevel Rural Community Engagement Model for Improving Childrens Dietary Intake in Family Child Care Homes

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PI_NAMEs: APPELBAUM, PAUL STUART;ELHADAD, NOEMIE ;KUSHNER, STEVEN A (contact);MARKX, SANDER

PROJECT_TITLE: 1/5 Clinical Outcome Prediction of Psychosis from EHRs (COPPER)


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: NEUROLOGY

PHR: Project Narrative Therapeutic development in ALS relies on the availability of robust biomarkers to asses drug efficacy and improve statistical power in clinical trials. Our work seeks to apply high resolution proteomic approaches to elucidate NfL, NfM, and NfH isoforms in sporadic and familial ALS biofluids that may serve as improved prognostic and/or pharmacodynamic biomarkers. In addition, we propose that in-depth comparison of protein abundance and kinetics of pre- and post-tofersen treatment biofluids from SOD1-ALS participants has the potential to reveal a proteomic signature of improvement in ALS that can be leveraged to identify novel disease pathways and biomarkers.

PI_NAMEs: LY, CINDY V (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Acceleration;Affect;Aftercare;Amyloid;Amyotrophic Lateral Sclerosis;Antioxidants;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Autopsy;biobank;Biological Assay;Biological Markers;Biology;Blood;Central Nervous System;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Cessation of life;Clinical;clinical biomarkers;Clinical Trials;Collection;Complement;Complex;Cytoskeleton;Development;Digestion;Disease;Disease Pathway;Disease Progression;Doctor of Medicine;Doctor of Philosophy;drug efficacy;Drug Kinetics;familial amyotrophic lateral sclerosis;Foundations;glycosylation;Grant;Half-Life;Health;Human;Immunoassay;Immunoprecipitation;improved;in vivo;Inherited;Kinetics;Length;Leucine;Light;Link;Maps;Mass Spectrum Analysis;Measures;Messenger RNA;Methods;Modification;Motor Neurons;mutant;Mutation;Nerve Degeneration;Nerve Tissue;Nervous System Disorder;Neurodegenerative Disorders;neurofilament;neuromuscular;Neurons;neuroprotection;novel;Participant;Pathogenicity;Pathologic;Performance;Peripheral Nervous System;peripherin;pharmacodynamic biomarker;pharmacologic;phase 3 study;Phosphorylation;Physicians;Plasma;Population;Post-Translational Protein Processing;prognostic;Prognostic Marker;programs;protein aggregation;Protein Biosynthesis;protein degradation;protein expression;Protein Isoforms;Proteins;Proteolysis;proteomic signature;Proteomics;Reagent;Recommendation;Regulation;Resolution;Respiratory Failure;response;Sampling;Scientist;Serum;Signal Transduction;sporadic amyotrophic lateral sclerosis;Stable Isotope Labeling;Stress;Superoxide Dismutase;Symptoms;tau Proteins;Tertiary Protein Structure;Therapeutic;therapeutic development;Tissues;Universities;Washington;Work

PROJECT_TITLE: Identifying mechanisms of neurofilament regulation and turnover in amyotrophic lateral sclerosis

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Prevention;Primary Health Care;Telehealth

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative To successfully control hypertension in Ghana, Nigeria and Africa, we need new ways to treat chronic diseases. Even though there is a lot of proof about effective, long-term ways to control hypertension, these strategies have not been used equally in places with few resources, like Ghana and Nigeria. We want to see if the ADHINCRA Program, an innovative, patient-centered, program that includes home blood pressure monitoring, mobile health technology, team-based care with doctors and nurses, and adjustments to medicines by nurses using an adapted, simplified hypertension treatment protocol, improves hypertension control in Ghana and Nigeria compared to usual care.

PI_NAMEs: COMMODORE-MENSAH, YVONNE  (contact);OJJI, DIKE BEVIS;SARFO, FRED STEPHEN

PROGRAM_OFFICER_NAME: BRUNO, FERNANDO PEREIRA

PROJECT_TERMS: Address;Adoption;Adult;Africa;African;Age;aging population;Assessment tool;Awareness;Blood Glucose;Blood Pressure;blood pressure control;blood pressure reduction;Brain hemorrhage;Cardiovascular Diseases;cardiovascular disorder risk;Caring;Cessation of life;Chronic Disease;Chronic Kidney Failure;Clinical;Cluster randomized trial;comparison intervention;Complication;contextual factors;cost effective;cost effectiveness;Counseling;Country;COVID-19 pandemic;Data;design;Diabetes Mellitus;Diagnosis;digital;Disease;disease disparity;Disease Management;dissemination strategy;effectiveness/implementation design;Engineering;Epidemic;Evaluation;evidence base;Evidence based intervention;experience;Ghana;global health;Government;Health;Health Personnel;Health Services Accessibility;Health system;Health Technology;Heart;Heart failure;High Prevalence;Home;Home Blood Pressure Monitoring;Hospitals;Hybrids;Hypertension;hypertension control;hypertension treatment;implementation strategy;improved;Income;indexing;innovation;Intervention;Kidney Diseases;Life Style;Link;Maintenance;medication compliance;Medicine;mHealth;monitoring device;mortality;Nigeria;Nigerian;Nurses;Obesity;older adult;patient oriented;Patients;Persons;Physicians;Pilot Projects;pilot trial;Policies;Population Growth;Practical Robust Implementation and Sustainability Model;premature;Prevalence;Primary Care;primary health center;primary outcome;programs;Protocols documentation;Provider;provider factors;provider-level barriers;Randomized;Readiness;Recommendation;recruit;Reporting;Resources;Risk Factors;secondary outcome;Self Management;Signal Transduction;Site;Standardization;Stroke;Sustainable Development;System;system-level barriers;Teaching Hospitals;team-based care;telehealth;telemonitoring;Testing;Text Messaging;treatment arm;treatment as usual;Treatment Protocols;trend;Universities;usual care arm;Work;World Health Organization;young adult

PROJECT_TITLE: The ADHINCRA Study: Addressing HypertensIoN Care in AfRicA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (02)]


NIH_SPENDING_CATS: Contraception/Reproduction;Infant Mortality;Lung;Maternal Health;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Preterm birth is the leading cause of neonatal death worldwide, and those who survive commonly have long- term negative health consequences. The work proposed here on immune cells at the maternal-fetal interface may lead to new treatments to prevent preterm birth and improve outcomes for preterm infants.

PI_NAMEs: GOMEZ-LOPEZ, NARDHY  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Address;adverse pregnancy outcome;amniotic cavity;Amniotic Fluid;Antiinflammatory Effect;Apoptosis;Biological Assay;Birth;Bone Marrow;CD8-Positive T-Lymphocytes;cell injury;Cell Physiology;Cell Separation;Cells;Chimera organism;Chronic;Clinical;cytokine;Cytometry;cytotoxicity;Data;Decidua;Development;Disease;effector T cell;Embryo Transfer;Etiology;FDA approved;fetal;Fetal Lung;Fetal Membranes;Fetal Tissues;Functional disorder;Gestational Age;Goals;Health;Hematopoietic;Heterozygote;Human;human RNA sequencing;Image;Immune;Immune Targeting;Immunity;Immunology;Immunophenotyping;improved;improved outcome;in utero;Infiltration;Inflammation;Inflammatory;innovation;Interleukin-9;Intestines;intraamniotic infection;Maps;Maternal-Fetal Exchange;Measures;mouse model;Mus;myometrium;neonatal airway;neonatal morbidity;Neonatal Mortality;neonatal outcome;novel strategies;offspring;Organ;Outcome;Partner in relationship;Patients;Phenotype;Placenta;Play;Pregnancy;Premature Birth;Premature Infant;Premature Labor;prenatal;prevent;Proliferating;Publishing;Reporting;Reproductive Health;Research;response;Risk Reduction;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Syndrome;T cell infiltration;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Tissues;transcriptomics;trophoblast;Uterus;Vitamin D;Vitamin D supplementation;Woman;Work

PROJECT_TITLE: T Cells and IL-9 Signaling at the Maternal-Fetal Interface in Preterm Labor and Birth

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 HSC-X (M1)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE The ability of bacteria to actively export (efflux) antibiotics is a prominent mechanism of drug resistance, common among many serious bacterial pathogens and a major contributor to the escalating global antibiotic resistance health crisis. This proposal aims to define the molecular mechanisms that regulate expression and activity of one such efflux pump in an important bacterial pathogen. These studies will broadly enhance our understanding of bacterial responses to antibiotics and bacterial efflux drug systems, and will support the future goal of developing novel strategies to counter the antibiotic resistance they confer.

PI_NAMEs: CONN, GRAEME L;DUNHAM, CHRISTINE M (contact);KEILER, KENNETH C

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: acute infection;Adjuvant;Aminoglycoside Antibiotics;Aminoglycosides;antibiotic efflux;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Bacteria;Bacterial Antibiotic Resistance;bacterial genetics;base;beta-Lactams;Biology;Carrier Proteins;Cell division;Cells;Centers for Disease Control and Prevention (U.S.);chronic infection;Clinical;clinically relevant;Complex;cystic fibrosis infection;cystic fibrosis patients;Dangerousness;Data;Development;Drug Efflux;Drug resistance;efflux pump;Engineering;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Health;Healthcare;Human;In Vitro;Individual;Infection;insight;Ion Channel;Ligands;Link;Macrolides;Mediating;Membrane Transport Proteins;Modern Medicine;Molecular;molecular dynamics;Multi-Drug Resistance;multidrug-resistant Pseudomonas aeruginosa;next generation;novel;novel strategies;Operon;opportunistic pathogen;pathogen;pathogenic bacteria;Pathway interactions;Patients;periplasm;Pharmaceutical Preparations;Physiology;Predisposition;Process;Production;programs;Proteins;Proton-Motive Force;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pump;Regulation;Research;Research Personnel;Resistance;resistance mechanism;Resolution;response;Ribosomes;Role;Site;structural biology;Structure;Substrate Specificity;System;therapeutic target;Tobramycin;translation factor;Translations;Up-Regulation;uptake;Variant;Xenobiotics

PROJECT_TITLE: Regulation and mechanism of RND-mediated antibiotic efflux in Pseudomonas

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


NIH_SPENDING_CATS: Clinical Research;Lung;Rare Diseases

PHR: Fibroblast-macrophage interaction is important for organ tissue homeostasis and if disease is present, poor outcomes. The studies in this application will investigate a way by which these cells interact to cause progression of asbestos-induced toxicity.

PI_NAMEs: CARTER, A BRENT (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Accreditation;Adverse effects;aerobic glycolysis;Affect;Alveolar Macrophages;Antibodies;Asbestos;Asbestosis;Attenuated;Binding;Bioenergetics;Body System;Carnitine;Cell Communication;cell type;Cells;Cessation of life;ChIP-seq;Coculture Techniques;Communication;CSF1 gene;curative treatments;Data;Disease;Disease Outcome;druggable target;Erinaceidae;exposed human population;Exposure to;fatty acid oxidation;Fibroblasts;Fibrosis;Genes;Genus Hippocampus;Glioma;Heart;Homeostasis;Human;human subject;human tissue;inhibitor;innovation;insight;Kidney;Liver;Lung;lung injury;Macrophage;Macrophage Activation;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metabolic;metabolic profile;Metabolism;Mitochondria;Molecular;monocyte;Mus;Oncogenes;Organ;Outcome;Pathway interactions;pharmacologic;Phenotype;Platelet-Derived Growth Factor;Production;Proteins;Pulmonary Fibrosis;Recombinants;response;Role;SHH gene;Signal Transduction;smoothened signaling pathway;Source;Techniques;Testing;therapeutic target;Tissues;Toxic effect;Transgenic Mice;United States

PROJECT_TITLE: Macrophage-fibroblast interaction is required for asbestos-induced toxicity

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]