NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Despite consensus on a clear set of effective kidney-protective strategies to reduce the risk of acute kidney injury (AKI), these treatments are often underutilized during surgery because perioperative risk of AKI is underestimated; as a result, AKI affects 18-47% of surgical patients and is associated with adverse outcomes including chronic kidney disease, major adverse cardiovascular events (MACE), increased healthcare costs, and death. This problem provides an excellent opportunity for machine learning (ML) because ML has already been shown to predict AKI better than clinicians, but these models have not yet been implemented in the perioperative period because of multiple technical and logistical barriers that we have developed technology to overcome. We propose implementing and updating innovative models that predict and alert clinicians of impending perioperative AKI during surgery when preventative treatments can be provided and, in the process, use these models to better understand the landscape of risk and design new treatments for AKI.

PI_NAMEs: BISHARA, ANDREW  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: abdominal pressure;acute care;Acute Renal Failure with Renal Papillary Necrosis;Adoption;Adult;adverse outcome;Affect;Algorithms;Anesthesia procedures;Anti-Inflammatory Agents;Area;Artificial Intelligence;Biometry;blood pressure elevation;Bolus Infusion;Cardiovascular system;care providers;career development;Cessation of life;Chronic Kidney Failure;Clinical;clinical care;Clinical Trials;Collaborations;Complex;computerized tools;Consensus;Costs and Benefits;Critical Care;Data;Data Science;Decision Making;design;Development;Electronic Health Record;Event;experience;experimental study;Faculty;Focus Groups;Future;Goals;graduate student;Health Care Costs;Healthcare;high risk;Human;human-robot interaction;Hypertension;hypoperfusion;Hypotension;Hypoxemia;implementation science;improved;indexing;Inflammation;innovation;Institution;Intervention;Intervention Studies;Intra-abdominal;Kidney;Learning;Liquid substance;Literature;Machine Learning;machine learning model;machine learning prediction;Medicine;Mentors;model development;Modeling;modifiable risk;Monitor;nephrotoxicity;new technology;novel;Operating Rooms;Operative Surgical Procedures;Outcome;Patient Care;Patients;Performance;Perioperative;Perioperative Care;personalized medicine;Physicians;Physiologic pulse;Physiological;Positioning Attribute;Postdoctoral Fellow;Postoperative Period;predictive modeling;prevent;Prevention strategy;Preventive measure;Preventive treatment;Process;prognostic;programs;prospective;Provider;Public Health;Publications;Publishing;Pulse Oximetry;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;responsible research conduct;Retrospective cohort;Risk;Risk Assessment;Risk Factors;Risk Reduction;risk stratification;Running;safety assessment;Services;Specificity;Statistical Models;statistics;Stress;surgical risk;System;Techniques;Technology;Time;tool;Training;training project;undergraduate student;United States National Institutes of Health;Update;urinary tract obstruction;Validation;Venous;Visualization;Work

PROJECT_TITLE: Real-time Prediction of Adverse Outcomes After Surgery

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: LAWRENCE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE  Non-human primate (NHP) models are ideal animal models for preclinical, translational stroke research; however, limitations on imaging modalities that can map neural activates in deep brains of awake monkeys are hindering the current research. We propose to develop a wearable, whole brain functional mapping system based on the emerging photoacoustic imaging for ischemic stroke research with NHP models. The success of this study will allow us to answer important scientific questions about stroke with NHP models, and pave the way for new stroke therapy development.

PI_NAMEs: NUDO, RANDOLPH J.;WANG, XUEDING ;YANG, XINMAI  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: 3-Dimensional;absorption;Action Potentials;Acute;Alzheimer's Disease;Animal Behavior;Animal Model;Animals;Area;Autopsy;awake;Behavior;Behavioral;Blood;Blood flow;Blood Volume;Brain;Brain imaging;Brain Mapping;Brain region;brain research;Cause of Death;Cephalic;cerebral artery;cerebral hemodynamics;cerebrovascular;Chronic;clinically relevant;cost;design;Development;Disease;efficacious treatment;Epilepsy;Failure;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;hemodynamics;Human;Image;imaging approach;imaging modality;imaging platform;imaging probe;imaging system;Imaging technology;Implanted Electrodes;in vivo;Industry;Ischemic Stroke;Lateral;Light;Link;Long term disability;Longitudinal Studies;Macaca mulatta;Maps;Metabolic Marker;method development;Microelectrodes;Modality;Modeling;Monitor;Monkeys;Morphologic artifacts;Motion;Motor;Motor Cortex;neural;Neuroanatomy;neuroprotection;nonhuman primate;Optics;Outcome;Oxygen Consumption;Parkinson Disease;Perfusion;Pharmaceutical Preparations;photoacoustic imaging;Play;post stroke;Pre-Clinical Model;preclinical study;Process;Real-Time Systems;Recommendation;Recovery;Research;Resolution;response;Rodent;Role;sound;Stroke;stroke model;stroke therapy;success;Surface;System;Techniques;Technology;temporal measurement;Thalamic structure;therapy development;Time;tool;Training;Translating;Ultrasonic Transducer;United States;United States National Institutes of Health;Vascular remodeling;Visualization;wearable device

PROJECT_TITLE: Wearable real-time functional brain mapping for a non-human primate stroke model

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Prevention

ORG_CITY: SALT LAKE CITY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The high prevalence of weight regain following intentional weight loss is the most significant and unresolved challenge in obesity medicine. This project will utilize qualitative data to design and then pilot, an adaptive intervention to prevent weight regain following weight loss in adults with obesity. This line of research will ultimately improve the health and clinical care of adults with obesity.

PI_NAMEs: HALLIDAY, TANYA MICHELLE (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: adaptive intervention;Address;Adult;adult obesity;arm;Body Weight decreased;career development;Caring;Clinical;clinical care;Clinical Investigator;Clinical Trials;Clinical Trials Design;clinically significant;college;Complex;Data;design;Development;diet and exercise;effective intervention;Enrollment;evidence base;experience;feasibility trial;Feedback;follow-up;Foundations;Future;Goals;Health;Health behavior;Healthcare;Heterogeneity;High Prevalence;improved;Individual;innovation;Intervention;Interview;Kinesiology;Knowledge;Leadership;Life Style;Link;Maintenance;Manuscripts;Measures;Medicine;Mentored Research Scientist Development Award;Mentors;Methods;Mollies;Morbidity - disease rate;mortality;novel strategies;Obesity;obesity management;Outcome;Outcome Measure;Overweight;Participant;patient engagement;patient oriented;Patients;Physical activity;Physicians;pilot test;Positioning Attribute;preference;prevent;professor;Qualitative Research;Relapse;Research;Research Design;Research Methodology;Resources;Risk;Risk Factors;Scientist;skills;Smoking;Specific qualifier value;Structure;Testing;translational scientist;trial design;Universities;Utah;Weight;weight loss intervention;Weight maintenance regimen;Work

PROJECT_TITLE: Development and Pilot Testing of an Adaptive Intervention to Prevent Weight Regain Following Weight Loss in Adults with Overweight and Obesity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Genetics;HIV/AIDS

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Older adults with HIV (OAH) experience more co-morbidities than their HIV negative peers despite viral suppression with antiretroviral medications, and inflammatory changes with aging in the setting of HIV remain incompletely understood. New biomarkers are needed to identify OAH at higher risk of geriatric syndromes, and recent advances in understanding of cellular death processes, including necrosis-mediated cell death, have allowed for measurement of cell-free mitochondrial DNA (cfmtDNA) as a novel biomarker. The goals of this proposal are to investigate cfmtDNA in plasma and urine as a biomarker of geriatric syndromes in a longitudinal study of OAH, evaluate the immunostimulatory potential of cfmtDNA, and foster the career development of a physician-scientist who has, and will continue to, dedicate her career to HIV research.

PI_NAMEs: JOHNSTON, CARRIE DOWN (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;Advisory Committees;Age;Aging;aging related;Anti-Retroviral Agents;Back;biobank;Biological Markers;Biostatistical Methods;Blood;Body Weight decreased;career;career development;Caring;Cell Death;Cells;Cessation of life;Chronic;Clinical;clinical care;clinical investigation;Coculture Techniques;Cognition;cognitive function;cognitive performance;cognitive testing;cohort;comorbidity;Data;Dedications;DNA;Elderly;Epidemic;Eugenia;Evaluation;experience;experimental study;falls;forging;Fostering;Foundations;frailty;Functional disorder;Gene Activation;Geriatrics;Geroscience;Goals;high risk;HIV;HIV Seronegativity;Immune;immune activation;Immunologic Stimulation;Immunology;Impaired cognition;improved;In Vitro;Inflammation;Inflammatory;inflammatory marker;insight;Institution;instrumental activity of daily living;Interferons;Intervention;Investigation;Link;Longitudinal Studies;Master of Science;Measurement;Measures;Mediating;Mediator;Medical;Mentors;Mentorship;Mitochondrial DNA;Molecular;Morbidity - disease rate;mortality;Natural Immunity;Necrosis;Nested Case-Control Study;Neurocognitive;Neuropsychology;novel marker;older adult;Participant;Pattern;peer;Performance;Pharmaceutical Preparations;Phenotype;Physical Function;Physical Performance;Physicians;Plasma;Plasma Cells;Ploidies;pro-aging;Process;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Risk;Role;sample collection;Scientist;skills;Stress;success;Syndrome;Testing;Time;tool;Training;Training Programs;transcriptome sequencing;Translational Research;translational study;urinary;Urine;Viral;Viremia;Visit

PROJECT_TITLE: Aging with HIV: Novel Biomarkers of Inflammation and Morbidity

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_CITY: SANTA BARBARA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Patterns of DNA methylation changes between species can be used to understand which regions of the genome are functionally important and relevant for diseases, yet are currently unknown. In this project, we will construct evolutionary histories of DNA methylation from three major cell types from two distinctive regions of human and non-human primate brains. This will help us determine how DNA methylation has changed during human brain evolution and how it underlies neuropsychiatric diseases. 1

PI_NAMEs: KONOPKA, GENEVIEVE ;SHERWOOD, CHESTER ;YI, SOOJIN  (contact)

PROGRAM_OFFICER_NAME: WETTERSTRAND, KRIS A

PROJECT_TERMS: Address;Affect;Anatomy;Area;Brain;brain cell;Brain region;brain size;Candidate Disease Gene;cell type;Cellular Structures;Chemicals;comparative;Comparative Study;Data;Development;Developmental Process;Disease;Distal;Distant;DNA analysis;DNA Methylation;empowerment;Enhancers;Epigenetic Process;epigenome;epigenomics;Event;Evolution;excitatory neuron;Exhibits;Gene Expression;Gene Expression Regulation;Genes;Genetic Risk;Genome;Genomic Segment;Haplorhini;Heterogeneity;Histologic;Human;Immunohistochemistry;Individual;inhibitory neuron;insight;Knowledge;knowledge integration;Learning;Link;Macaca mulatta;Mammals;Memory;Methylation;methylome;Modification;Molecular;Monkeys;Neuroglia;Neurons;neuropsychiatric disorder;nonhuman primate;novel;Oligodendroglia;Pan Genus;Pattern;Phenotype;Phylogenetic Analysis;Phylogeny;Play;Pongidae;Pontine structure;Positioning Attribute;Prefrontal Cortex;Primates;promoter;Recording of previous events;regional difference;Research;Resolution;Role;species difference;Testing;Tissues;trait;Untranslated RNA;Validation;validation studies;Variant;Work

PROJECT_TITLE: Comparative Epigenomics of Primate Brains

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Patient Safety;Social Determinants of Health

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative Infectious disease epidemiology has increasingly needed to understand the dynamics of infection in small, highly structured populations, such as hospitals, schools, nursing homes and workplaces. The tools and evidence based for the dynamics of these populations are, however, underdeveloped when compared to those for large, population-scale epidemics. The proposed research program will extend our understanding of the stochastic dynamics of these populations and support the development of a broader range of tools or methods for studying pathogen transmission in these populations.

PI_NAMEs: LOFGREN, ERIC T (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Affect;Architecture;Area;Argentina;built environment;computerized tools;Country;Data;Development;Disease;disease model;Disease Outbreaks;disease transmission;Eastern Africa;Ecology;Environment;Epidemic;Epidemiology;evidence base;Foundations;Geography;Goals;Group Structure;Health care facility;Healthcare;healthcare-associated infections;Hospitals;Individual;Infection;Infectious Disease Epidemiology;Information Theory;Machine Learning;mathematical model;method development;Methodology;Methods;Modeling;new epidemic;novel;Nursing Homes;organizational structure;Output;Paper;pathogen;Patient risk;Pattern;Persons;Policies;Policy Maker;Population;Population Dynamics;programs;Public Health;Research;Running;Rural Population;Schools;Structure;synthetic data;tool;transmission process;United States;Universities;Variant;Vision;Washington;web based software;Work;Workplace

PROJECT_TITLE: Methods and Tools for Understanding Disease Dynamics in Small, Structured Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the development of a rapid and efficient Mucor circinelloides genetic manipulation system will contribute to both the advancement of our understanding of this pathogen and the development of novel strategies to treat infections caused by M. circinelloides. The research is therefore relevant to the part of the National Institute of Allergy and Infectious Diseases' mission that pertains to supporting basic and applied research to better understand, treat, and ultimately prevent infectious diseases, particularly with regards to infections caused by antimicrobial-resistant pathogens.

PI_NAMEs: RYBAK, JEFFREY M. (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Acceleration;Address;Affect;anti-fungal agents;Antifungal Therapy;antimicrobial resistant pathogen;Applied Research;Aspergillus fumigatus;Azoles;Basic Science;Candida albicans;Cell Nucleus;Cells;Characteristics;Clinical;Communicable Diseases;CRISPR/Cas technology;Cyanogen Bromide;Death Rate;Development;Diabetes Mellitus;DNA cassette;efflux pump;Etiology;Foundations;Fungal Drug Resistance;fungus;Future;gene drive system;gene editing technology;Gene Family;Genes;Genetic;genetic manipulation;Genetic Markers;genetic technology;Genetic Transcription;Genome;Goals;Guide RNA;Immunocompromised Host;Infection;innovation;Investigation;Knowledge;Life;Mediating;Mission;model organism;Modeling;Modernization;Molds;Molecular;Morphology;Mucor;Mucormycosis;Mycoses;National Institute of Allergy and Infectious Disease;Nature;novel;novel strategies;novel therapeutic intervention;Organism;Orthologous Gene;Outcome;paralogous gene;pathogen;pathogenic fungus;patient population;Patients;Phenotype;Population;posaconazole;Predisposition;preservation;prevent;Public Health;Reproduction spores;Research;response;Septate;System;Testing;Therapeutic;therapeutic development;Time;tool;Work

PROJECT_TITLE: Development of M-Drive: A recyclable Mucor-optimized CAS9 gene-drive system cable of multi-target gene editing

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Lymphatic Research;Machine Learning and Artificial Intelligence;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE In definitive radiation therapy for head and neck cancer patients, there is often significant uncertainty about the malignant potential of cervical lymph nodes during treatment target identification. We will develop an advanced machine learning method through analyzing PET and CT images and patient clinical characteristics to accurately predict lymph node metastasis status. This tool will be deployed in a prospective randomized trial to show how strictly irradiating these identified lymph nodes, rather than the entire at-risk cervical neck, is oncologically sound and associated with improved quality-of-life.

PI_NAMEs: SHER, DAVID ;WANG, JING  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Acute;Address;Algorithms;Area;arm;Benign;Cancer Patient;Cervical;Cervical lymph node group;Characteristics;chemoradiation;Classification;Clinical;clinical investigation;cohort;convolutional neural network;Data;Databases;Deglutition Disorders;design;Development;Disease;Dose;draining lymph node;efficacy evaluation;Emission-Computed Tomography;Evaluation;External Beam Radiation Therapy;Failure;flexibility;follow-up;Goals;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;high risk;Image;imaging modality;improved;improved outcome;Intensity-Modulated Radiotherapy;Lead;Lung;lymph nodes;lymphadenopathy;Lymphoma;machine learning method;Malignant - descriptor;Malignant Neoplasms;Metastatic Neoplasm to Lymph Nodes;Modality;Modeling;multimodal modeling;multimodality;Neck;Nodal;Operative Surgical Procedures;overtreatment;Pancreas;Pathology;Patients;Performance;Pharyngeal structure;Phase;phase 2 study;Phase II Clinical Trials;Positron-Emission Tomography;predictive modeling;predictive tools;Probability;prophylactic;prospective;Quality of life;quantitative imaging;Radiation Dose Unit;Radiation therapy;radiomics;Randomized;randomized trial;Recurrence;Registries;Risk;Risk Estimate;Sensitivity and Specificity;Site;soft tissue;sound;Source;standard of care;Testing;Therapeutic;tool;Toxic effect;Training;Tumor Volume;Uncertainty;Validation;X-Ray Computed Tomography;Xerostomia

PROJECT_TITLE: A Multifaceted Radiomics Model to Predict Cervical Lymph Node Metastasis for Involved Nodal Radiation Therapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Live-attenuated vaccines against dengue have struggled to achieve high efficacy and safety in children without previous dengue infection and in children under 9 years old. We do not yet know the immunologic determinants of protection in natural dengue infections, nor do we understand how age impacts the development of neutralizing antibodies in previously uninfected children. The findings of this study on infection risk and antibody targets in younger and older children, controlling for prior dengue infection, will inform future vaccine development and improve vaccine safety analyses.

PI_NAMEs: ZHU, DEANNA  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 11 year old;5 year old;9 year old;Affect;Age;age effect;age group;Americas;Antibodies;Antibody Avidity;Antibody Response;Antibody Specificity;Antigen-Antibody Complex;Attenuated;Attenuated Vaccines;Binding;breakthrough infection;Cells;Child;Childhood;Chimera organism;cohort;Cohort Studies;Complex;Country;Cross Reactions;cross reactivity;Data;Data Set;Dengue;Dengue Hemorrhagic Fever;Dengue Infection;Dengue Shock Syndrome;Dengue Vaccine;Dengue Virus;Dengvaxia;Development;Disease;Disease Outbreaks;Doctor of Philosophy;domain mapping;E protein;Engineering;Enrollment;Ensure;Epidemiologic Methods;Epidemiology;Epitopes;Event;Exclusion;Fellowship;Fever;Filipino;follow-up;Future;Genotype;global temperature;Glycoproteins;Health;Hospitalization;Human;human monoclonal antibodies;Immune response;Immunity;Immunize;Immunologics;Immunology;improved;Incidence;Individual;Infection;infection risk;Infectious Disease Epidemiology;Intervention;Latin American;Life;Longitudinal Studies;Longitudinal, observational study;Measles;Mediation;Mentors;Methods;Monitor;Monoclonal Antibodies;neutralizing antibody;Nicaragua;North Carolina;Outcome;Parents;Pathogenesis;Pattern;phase III trial;Philippines;Physicians;Policies;Population;population health;Primary Infection;Production;recombinant virus;Recombinants;Recording of previous events;Research;response;Risk;Risk Assessment;Role;Safety;Sampling;Schools;Scientist;Serology;Serotyping;Serum;skills;Specificity;Techniques;Time;Training;Travel;Universities;Vaccinated;Vaccination;vaccine acceptance;vaccine development;vaccine efficacy;vaccine safety;Vaccines;Variant;vector;vector-borne;Viral;virology;Virus;virus envelope;Yellow Fever

PROJECT_TITLE: Age in dengue antibody response and risk after primary natural infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F13-Z(20)L]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Violence Research;Youth Violence

ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PHR: Relevance This project uses a social determinants of health framework to identify types of trauma exposures during emerging adulthood that influence the course of adult substance use to incarceration in the US. Identifying modifiable factors in the neighborhood environment that are important for race and ethnicity groups can provide a knowledge base for tailored intervention opportunities aimed at ameliorating health and social inequities.

PI_NAMEs: TAM, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Acceleration;Accounting;Address;Adolescence;Adolescent;Adult;Affect;Age;Alcohol consumption;Attenuated;Black American;Black Populations;Black race;Buffers;Cannabis;childhood adversity;Cohort Studies;Communities;community violence;Data;Development;Discrimination;Disparity;Drug abuse;Drug usage;Economics;emerging adult;emerging adulthood;Environment;epidemiology study;ethnic difference;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;experience;Faith;Family;Funding;General Population;Health;health service use;High Prevalence;Hispanic;Hispanic Americans;Hispanic Populations;illicit drug use;Imprisonment;improve minority health;improved;Inequity;innovation;Institution;Intervention;intimate partner violence;knowledge base;Latinx;Latinx population;Legal system;Life;Life Cycle Stages;Link;Longitudinal Studies;Measures;Mediating;Mediation;Mental Health Services;Mentorship;middle age;minority communities;minority health;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;National Longitudinal Survey of Adolescent to Adult Health;National Survey of Adolescents;Neighborhoods;Pathway interactions;Pattern;Persons;Population;prevent;Prevention;promote resilience;Race;racial difference;racial disparity;racial diversity;Racial Equity;racial minority;racial population;Research;response;Risk;Role;Sampling;Science;Scoring Method;secondary analysis;social;Social Change;social health determinants;Social Identification;Social support;Stress;Structural Models;substance use;Techniques;Time;Translations;Trauma;trauma exposure;Trauma Research;traumatic event;Vacuum;Victimization;violence exposure;virtual;Youth

PROJECT_TITLE: Trauma, Substance Use, and Incarceration Over the Lifecourse: Identifying Social Supports to Promote Resiliency in a US National Cohort Study


NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE There are currently few data pertaining to fracture risk and the association of bone density and fracture risk in US Asians. This study will examine fracture incidence in Asian women and will assess the accuracy of bone density and its combination with clinical factors in fracture risk calculating tools for predicting future fracture events. Findings from this study will inform ethnic-specific osteoporosis care for US Asians and minimize both under- and overtreatment in the clinical management of Asians who require osteoporosis counseling.

PI_NAMEs: LO, JOAN C (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Address;Age;Aging;Area;Asian;Asian Americans;Asian population;Asian Women;bisphosphonate;Black Populations;Bone Density;Calibration;California;Caring;Caucasians;China;Chinese;Clinical;Clinical Management;Counseling;Country;Data;Databases;Diagnosis;diagnostic tool;East Asian;Electronic Health Record;Epidemiology;epidemiology study;ethnic diversity;ethnic minority;Ethnic Origin;Ethnic Population;Event;Femoral Fractures;Femur;Filipino;Fracture;fracture risk;Future;Gender;hazard;Health;health plan;Healthcare;Hip Fractures;Hip region structure;Hispanic;Hispanic Populations;Home;Hong Kong;human old age (65+);humerus;Incidence;Integrated Delivery of Health Care;Integrated Health Care Systems;Japanese;Knowledge;Koreans;member;men;Neck;older patient;Online Systems;Osteoporosis;osteoporosis with pathological fracture;Outcome;overtreatment;Pharmaceutical Preparations;Philippines;Population;population based;Population Heterogeneity;predictive tools;Prevention;Probability;Race;Recommendation;Reporting;Risk;Risk Assessment;Risk Estimate;risk prediction;San Francisco;screening;skeletal;South Asian;southeast Asian;Southeastern Asia;spine bone structure;stem;Subgroup;System;Taiwan;Test Result;Testing;tool;treatment optimization;United States Preventative Services Task Force;Update;Variant;Vietnamese;White Women;Woman;Wrist

PROJECT_TITLE: Skeletal Health Outcomes among US Asian Women

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Human AML shows evidence of a hierarchical cellular organization, with a minor fraction of self-renewing leukemia stem cells (LSCs) at the apex of this hierarchy that must be eliminated to eradicate the disease and achieve long-term remissions. Although a number of cell surface markers have been characterized on AML LSC- enriched fractions, none are specific for LSCs or facilitate their rigorous purification making it difficult to further characterize LSC biology and to develop methods for more specific therapeutic targeting. This proposal seeks to rigorously characterize LSC properties and identify biological programs that contribute to AML pathogenesis, response to therapy, and clinical outcomes.

PI_NAMEs: MAJETI, RAVINDRA  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adult;Affect;aggressive therapy;Allogenic;Apical;Apoptosis;Architecture;Biological;Biology;Blast Cell;Bone Marrow;cancer stem cell;CD34 gene;Cell Cycle;Cell surface;Cells;cellular targeting;Chemoresistance;Clinical;clinical remission;clinically significant;cohort;Complex;conventional therapy;curative treatments;Cytometry;Development;Disease;Disease remission;Drug Efflux;Exhibits;Frequencies;Gene Expression Profile;Gene Frequency;Genes;Genomics;Hematopoietic Stem Cell Transplantation;Heterogeneity;High Dose Chemotherapy;Human;human old age (65+);Immunodeficient Mouse;Immunophenotyping;in silico;Investigation;leukemia;Leukemic Cell;leukemic stem cell;Malignant Neoplasms;Maps;Measurable;Methods;Minor;Mutation;Myeloid Cells;novel;Outcome;overexpression;Pathogenesis;Pathway interactions;Patients;Population;Predisposition;prognostic;programs;Property;Proteomics;Recording of previous events;Recurrent disease;Refractory;Regulation;Relapse;Residual Neoplasm;Resistance;Role;self-renewal;standard of care;stem cell biology;stem cell function;stem cell model;stem cell population;stem cell self renewal;subclonal heterogeneity;Therapeutic;therapeutic target;transcriptomics;Transplantation;treatment response;United States;Xenograft Model

PROJECT_TITLE: Human Acute Myeloid Leukemia Stem Cells

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The overall goals of this project are to leverage our expertise in animal models of TB and in vivo bioimaging to understand the biodistribution of new antimicrobials into diseased pulmonary tissues, specifically cavitary lesions. We will also gain mechanistic insights to optimize TB treatments and develop tools to accurately characterize and phenotype TB disease.

PI_NAMEs: JAIN, SANJAY  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Aftercare;analog;Anatomy;Animal Model;Animals;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Area;Autopsy;Autoradiography;bactericide;Binding Proteins;Biodistribution;bioimaging;Cause of Death;Characteristics;Chemicals;Clinical;clinical translation;cohort;Combined Modality Therapy;Data;density;design;Disease;Dose;drug development;Drug Exposure;Drug Kinetics;early detection biomarkers;Early identification;effective therapy;emerging antibiotic resistance;Evolution;experimental study;Extinction;Fiber;first-in-human;Goals;Health;Heterogeneity;Human;human disease;Image;imaging biomarker;Imaging Device;Immune;In Situ;in vivo;in vivo imaging;Infection;Inflammation;insight;Kinetics;Lesion;Linezolid;Link;Lung;Macrophage;Mass Spectrum Analysis;Measurement;Measures;Modeling;molecular imaging;Multidrug-Resistant Tuberculosis;Multimodal Imaging;Mus;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;novel;novel therapeutics;Oryctolagus cuniculus;Outcome;Parents;pathogen;Pathologic;Patients;Penetration;Pharmaceutical Preparations;pharmacokinetic model;Phenotype;Plasma;Population;Positron-Emission Tomography;Prediction of Response to Therapy;Predisposition;Property;radiological imaging;Recommendation;Recurrence;Regimen;Relapse;Research;Resistance;Rifampin;Risk Factors;Sampling Biases;Site;spatial integration;Strategic Planning;System;Time;Tissue Sample;Tissues;tool;Tracer;Translating;Treatment Factor;Treatment Failure;treatment optimization;Treatment outcome;treatment risk;treatment strategy;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Visualization;World Health Organization;X-Ray Computed Tomography

PROJECT_TITLE: Measuring Intralesional Drug Exposures in Cavitary TB using Noninvasive In Vivo PET Imaging

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ORG_CITY: ANN ARBOR

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE The kinesin superfamily of motor proteins orchestrates various cellular processes, necessitating careful control of kinesin activity. This project will determine the molecular details underlying kinesin inhibition via kinesin binding protein and kinesin light chain and provide a framework to understand how kinesin-driven cargo transport is regulated.

PI_NAMEs: CIANFROCCO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: ATP Hydrolysis;ATP phosphohydrolase;Axonal Transport;Binding;Binding Proteins;Biological;Cell division;Cell Physiology;Cells;Complement;Complex;Consensus;crosslink;Cryoelectron Microscopy;Cytoskeleton;Data;Elements;Ensure;Environment;experimental study;Fluorescence;Grant;Individual;Kinesin;Lead;Length;Light;Mass Spectrum Analysis;Mediating;Microtubules;Mitotic;Mitotic spindle;Modeling;Molecular;Molecular Conformation;Motility;Motor;Mutagenesis;mutant;Mutation;novel;organelle movement;Organelles;Patients;Peptides;Positioning Attribute;prevent;Property;Protein Engineering;Protein Family;Protein Inhibition;Protein Region;Proteins;Regulation;Reporting;Signal Transduction;Site-Directed Mutagenesis;spatiotemporal;Specificity;Structure;Tail;Testing;Work

PROJECT_TITLE: Mechanisms of kinesin motor protein inhibition

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


PHR: Project Narrative The proposed research is relevant to public health because it will increase our understanding of how pathogenic bacteria protect themselves from invasion by mobile genetic elements, such as viruses and plasmids. This is important because invasion by these elements is a major route by which bacteria acquire antibiotic-resistance and greater virulence. Thus, the proposed research is relevant to the NIH's goals of improving the control of disease, enhancing human health and advancing our understanding of biological systems.

PI_NAMEs: BAILEY, SCOTT  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3-Dimensional;Address;Antibiotic Resistance;Area;Bacteria;bacterial resistance;Bacteriophages;Base Pairing;Binding;Biochemical;Biological Sciences;biological systems;Biology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cryoelectron Microscopy;Development;disorder control;DNA;DNA Binding;DNA Sequence;Elements;Ensure;Exonuclease;experimental study;Feedback;Genetic;Genetic Transcription;Genome;Goals;Guide RNA;Health;Human;Immune response;Immunity;immunoregulation;improved;innovation;insight;Invaded;Knowledge;Mediating;Mobile Genetic Elements;Molecular;Mutate;Nucleic Acids;off-target site;Outcome;pathogenic bacteria;Pathway interactions;Plasmids;Play;Process;Prokaryotic Cells;Proteins;Public Health;Research;Research Design;Resistance;response;RNA Interference;Role;Route;Signal Transduction;single molecule;System;tool;United States National Institutes of Health;Virulence;Virus;Work

PROJECT_TITLE: Mechanistic Studies of the Type I CRISPR-Cas system


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This proposal explores a novel mechanism of presynaptic RNA binding proteins controlling target mRNAs to regulate learning and memory. Furthermore, because RNA binding protein dysfunction is known to play an important role in many neurological disorders such as Fragile X Syndrome, Autism, and Alzheimer’s, my studies may also give new insight into the role that RNA binding proteins play in neurological disease. Illuminating the importance of 1) presynaptic transcripts in learning and memory and 2) RNA binding proteins as memory regulators may reveal pathways suitable for pharmacological manipulation to treat diseases that cause cognitive dysfunction.

PI_NAMEs: HAYDEN, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Adult;Alzheimer's Disease;Animals;Area;autism spectrum disorder;Binding;Biological Assay;Caenorhabditis elegans;Cognitive;cognitive function;Communities;crosslink;Data;Disease;Drosophila genus;Ensure;Exhibits;experimental study;Family;Fluorescent in Situ Hybridization;Food;Fragile X Syndrome;Functional disorder;Genes;Genetic;Germ Lines;Health;Homologous Gene;Human;Immunoprecipitation;Impaired cognition;insight;Investigation;knock-down;Learning;long term memory;Mammals;Measures;Memory;Messenger RNA;Modeling;Molecular;mRNA Expression;Mus;Nematoda;Nervous System;Nervous System Disorder;neuronal cell body;Neurons;novel;Odors;Oogenesis;Organism;Pathway interactions;pharmacologic;Phenotype;Play;postsynaptic;presynaptic;Process;Protein Biosynthesis;Rattus;Regulation;Research;RNA Interference;RNA-Binding Proteins;Role;single molecule;Synapses;Synaptic plasticity;Testing;tool;Training;Transcript;transcriptome;Translations;vector control;virtual

PROJECT_TITLE: Presynaptic RNA binding protein regulation of learning and memory in C. elegans


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: EAST LANSING

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Mitochondria are the energy sources of cells and are abnormal in patients with diabetic retinopathy (DR). Recent studies demonstrate that mitochondrial transfer from stem cells can rescue damaged cells from bioenergetic abnormalities and cell death. In this proposal, we will “normalize” bioenergetics by mitochondrial transfer and prevent retinal vascular pathology associated with DR, this may provide a novel breakthrough approach to treatment of DR.

PI_NAMEs: GRANT, MARIA BARTOLOMEO;PROSHLYAKOV, DENIS A (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Address;bevacizumab;Binding;Bioenergetics;Biogenesis;Blood Vessels;Bone Marrow;bone repair;Carrier Proteins;CD34 gene;Cell Death;cell injury;Cells;Crista ampullaris;db/db mouse;Diabetes Mellitus;diabetic;Diabetic Retinopathy;directed differentiation;Disease;Early Diagnosis;Early treatment;Endoplasmic Reticulum;Endothelial Cells;endothelial stem cell;Endothelium;Energy-Generating Resources;Epigenetic Process;extracellular vesicles;Functional disorder;Growth Factor;Homing;Immunotherapy;Impairment;In Vitro;in vivo;injured;Injury;injury and repair;Intervention;macular edema;Mediating;Metabolic;Metabolism;migration;Mitochondria;Mitochondrial DNA;Mitochondrial Proteins;Nanotubes;neovascular;new therapeutic target;non-diabetic;novel;novel strategies;paracrine;Pathogenesis;Pathology;Patients;Play;prevent;Process;Proteins;Regulation;remediation;repair function;repaired;reparative capacity;restoration;Retina;retinal damage;Role;Signal Transduction;Site;stem cells;Surface;Swelling;Symptoms;Testing;vascular injury;Withdrawal

PROJECT_TITLE: Correction of diabetic retinopathy by mitochondrial transfer

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Black young adults use cannabis more frequently and are more likely to have a cannabis use disorder than White young adults, yet very few studies have examined why these differences exist. The proposed project tests a cascading model that examines stress and discrimination exposure, reactivity to stressors, and cannabis cognitions, inside the laboratory and in the natural environment, as contributors to health inequities in cannabis use and problems. Results of the project will inform culturally-responsive intervention efforts by identifying modifiable and proximal treatment targets for Black young adults and will ultimately lead to a reduction in the pronounced and growing health inequities in cannabis use and cannabis use disorder.

PI_NAMEs: PEDERSEN, SARAH L (contact)

PROJECT_TERMS: Acute;acute stress;Address;Adult;African American;Age Years;aged;assigned female at birth;Black American;Black Populations;Black race;Cannabis;cannabis craving;caucasian American;Characteristics;Chronic;Chronic stress;Cognition;Communities;community engaged research;coping;Coupling;craving;culturally appropriate intervention;Data;Development;Discrimination;Ecological momentary assessment;Education;emotion regulation;Emotional;Emotions;Enrollment;Ensure;Environment;Event;experience;follow-up;Frequencies;Funding;health equity;health inequalities;heart rate variability;Income;Individual;Inequity;Institutional Racism;Intervention;Interview;Laboratories;Literature;marijuana use;marijuana use disorder;Measures;Methods;Modeling;National Institute of Drug Abuse;Outcome;Participant;Persons;Physiological;Pilot Projects;Play;Policies;Population;Process;Protocols documentation;Public Health;Questionnaires;Race;racial difference;racial disparity;racial population;racism;recruit;Reporting;Research;Role;Sampling;sex;socioeconomic disadvantage;Standardization;statistics;Stress;stressor;substance use;Surveys;Testing;Time;Transact;young adult

PROJECT_TITLE: A Multimethod Examination of Individual and Environment Contributors to Racial Inequities in Cannabis Use

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Aspergillus infections are associated with high morbidity and mortality in both immunocompetent and immunocompromised patients. To reduce the burden of aspergilloses, novel therapies targeted towards activating protective immunity or inhibiting harmful over-inflammation are needed. Our research aims to address this need by deciphering molecular pathways required for regulation of host-pathogen interactions.

PI_NAMEs: FORTWENDEL, JARROD R. (contact);PETERS, BRIAN M

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Allergic Bronchopulmonary Aspergillosis;Anabolism;Aspergillosis;Aspergillus;Aspergillus fumigatus;Asthma;Automobile Driving;biological adaptation to stress;Caspase;Cell Line;ChIP-seq;Chronic;chronic infection;Clinical;Coculture Techniques;Complex;Cystic Fibrosis;Death Rate;Development;diagnostic criteria;Fungal Components;fungus;Future;gene complementation;Gene Deletion;Gene Expression Profile;Gene Expression Profiling;Genetic Determinism;Genetic Epistasis;Genetic Transcription;Goals;Human;Immune response;Immunity;Immunocompetent;Immunocompromised Host;immunological status;immunopathology;improved outcome;In Vitro;in vivo;Individual;Infection;Inflammasome;Inflammation;Inflammatory Response;Interleukin-1 beta;Libraries;Macrophage;Masks;Measures;Mediating;Molecular;molecular assembly/self assembly;monocyte;Morbidity - disease rate;mortality;mouse model;mutant;new therapeutic target;novel;novel therapeutic intervention;Organism;pathogen;Pathogen detection;pathogenic fungus;Pathogenicity;Pathway interactions;Patients;Pattern;Peripheral Blood Mononuclear Cell;Phagocytosis;Process;Protein Kinase;protein-histidine kinase;Proteins;Regulation;Research;Research Design;respiratory;response;Role;Screening Result;sensor histidine kinase;Severities;Signal Transduction;Stimulus;Stress Response Signaling;Syndrome;therapeutic target;Tissue-Specific Gene Expression;tool;transcription factor;transcriptome sequencing;Virulence;Work

PROJECT_TITLE: Genetic Determinants of Aspergillus host-pathogen interactions


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Autism Spectrum Disorder affects 1 and 44 children, and racial/ethnic disparities profoundly impact access to care. Though most research has focused on child and family factors, other contextual factors such as neighborhood, state health policy, and educational system determinants are likely drivers of structural disparities in care. In this research we propose to identify cross-sector, modifiable determinants of autism diagnostic and treatment disparities by combining Medicaid data with information on neighborhoods, state policy, and state educational data, and we will use a stakeholder-engaged consensus panel to turn data into actionable interventions.

PI_NAMEs: LINDLY, OLIVIA J;ZUCKERMAN, KATHARINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: 3 year old;access disparities;Address;adolescent with autism spectrum disorder;adult with autism spectrum disorder;Affect;Age;Alaska Native;American Indians;Autism diagnostic;autism spectrum disorder;autistic children;Automobile Driving;base;Behavior Therapy;behavioral health;Big Data;Black race;Caring;Cessation of life;Child;Child health equity;child services;Childhood;children of color;Chronic;Communities;community based service;Complex;Consensus;contextual factors;Data;Data Aggregation;Data Analyses;data harmonization;data quality;Data Science;Data Set;Development;Diagnosis;Disparity;Disparity in diagnosis;disparity reduction;Early Intervention;Education;Equity;ethnic disparity;Ethnic Origin;evidence base;Family;Family member;Funding;General Population;Guidelines;Health;health care disparity;Health Disparities Research;health equity;health inequalities;Health Policy;Health Services;Health Services Accessibility;Health system;Healthcare;Home;improved;improved outcome;indexing;individuals with autism spectrum disorder;Information Systems;innovation;interest;Intervention;intervention program;Knowledge;life span;lower income families;Machine Learning;Measures;Medicaid;Medicine;Methods;National Institute of Mental Health;Neighborhoods;Nursery Schools;Pharmaceutical Preparations;Policies;Policy Maker;Prevalence;programs;psychopharmacologic;Race;racial determinant;racial disparity;Recommendation;Research;Research Personnel;Schools;screening;secondary analysis;Services;social;Special Education;Strategic Planning;structural health determinants;System;Techniques;treatment disparity;United States;United States National Institutes of Health;waiver;Work

PROJECT_TITLE: Addressing Structural Disparities in Autism Spectrum Disorder through Analysis of Secondary Data (ASD3)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PUBLIC HEALTH RELEVANCE/ PROJECT NARRATIVE Substance use and HIV have linked throughout history, from the first described cases of HIV/AIDS in the 1980s among men who have sex with men (MSM) also using psychostimulants through the present day, which is why it is so important to study the intersection of substance use and HIV. However, self‐reported substance use and the number of substances used is not always accurate and measures to quantitate substance use in hair samples are more objective and can be correlated with clinical outcomes, including HIV risk, HIV outcomes, and inflammation. Our laboratory at UCSF (the Hair Analytical Laboratory) has been analyzing HIV medications in hair samples for over two decades and proposes in this application to direct that expertise into developing hair assays for substances in order to 1) become a reference laboratory to provide hair assays of substances to groups studying substance use and HIV; 2) analyze hair substance use levels in a cohort study of MSM who use substances in relationship to self‐reported use, urine toxicology screens, and clinical outcomes for those at risk of or living with HIV; 3) assess the contribution of substance use as measured in hair with chronic inflammation.

PI_NAMEs: GANDHI, MONICA  (contact);GORBACH, PAMINA MAE

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Adherence;Affect;Age;AIDS prevention;Alcohol consumption;Alcohols;antiretroviral therapy;Behavior;biobank;biobehavior;Biological;Biological Assay;Biological Markers;Cannabis;Chronic;Clinic Visits;Clinical;Cocaine;cohort;Cohort Studies;Drug Exposure;Drug usage;ecstasy;Enrollment;Fentanyl;Forensic Medicine;Frequencies;Funding;good laboratory practice;Guidelines;Hair;Heroin;HIV;HIV risk;HIV Seronegativity;HIV/AIDS;Individual;infection risk;Inflammation;Inflammatory;Interleukin-6;Intervention;Laboratories;Lead;Link;Los Angeles;Measures;Memory;men of color;men who have sex with men;Methamphetamine;methamphetamine use;Methods;Monitor;National Institute of Drug Abuse;Opioid;Outcome;Overdose;Participant;Patient Self-Report;Pattern;Persons;Pharmaceutical Preparations;pharmacologic;Plasma;polysubstance use;Populations at Risk;pre-exposure prophylaxis;Productivity;Provider;public health relevance;Recording of previous events;Recovery;reduced substance use;Reporting;Research Personnel;research study;Risk;sample collection;Sampling;Scalp structure;Science;screening;Screening Result;Sexually Transmitted Diseases;Smoking;Social Desirability;Specificity;Specimen;stimulant use;substance use;substance use treatment;substance user;syndemic;systemic inflammatory response;Talents;Technical Expertise;Testing;time interval;TNF gene;Tobacco;tool;Toxicology;Treatment outcome;tuberculosis drugs;United States National Institutes of Health;Urine;Validation;young men who have sex with men

PROJECT_TITLE: Unraveling the intersection of substance use, inflammation, and HIV via hair levels

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Kidney Disease;Urologic Diseases

PHR: The proposed research is relevant to public health because the study of the nutrient acquisition via transporters of uropathogenic bacteria E. coli and Proteus mirabilis will lead to a better understanding of how these agents of urinary tract infection cause the second most frequent infection in humans. This work is consistent with the NIH/NIAID mission, which is to conduct and support basic and applied research to better understand, treat, and ultimately prevent infectious diseases.

PI_NAMEs: PEARSON, MELANIE M. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute Cystitis;acute pyelonephritis;Adherence;Affect;Affinity;Agar;Amino Acids;Amino Sugars;antimicrobial;Antimicrobial Resistance;Applied Research;Area;ascending urinary tract infection;Bacteremia;Bacteria;Bacterial Adhesins;Bacterial Infections;Basic Science;Biological Assay;Birth;Bladder;Bladder Calculi;Body Surface;Categories;catheter associated UTI;Catheters;Colon;Communicable Diseases;Complex;Data;Defect;Deformity;Development;economic impact;Enterobacteriaceae;Epithelium;Escherichia coli;fitness;Funding;Future;Genes;Goals;Grant;Growth;heme-binding protein;Hemolysin;Hospitals;Human;in vivo;Individual;Infection;Iron;Kidney;Kidney Calculi;Kidney Diseases;Kinetics;Libraries;Life;Measures;Mediating;meetings;member;Metabolism;metabolome;Mission;Molecular;Motility;mouse model;Mus;mutant;Mutate;National Institute of Allergy and Infectious Disease;Newborn Infant;novel;Nutrient;Obstruction;Organism;Outcome;pathogen;Peptide Hydrolases;Peptides;Persons;Phenotype;Physicians;Population;Predisposition;prevent;Productivity;Proteus mirabilis;Public Health;Radiolabeled;Reflux;renal scarring;Reporting;Research;Rest;Siderophores;Site;small molecule;Structural defect;success;Surface;Symptoms;System;Testing;Time;Toxin;transcriptome;transcriptome sequencing;transposon sequencing;Tube;United States;United States National Institutes of Health;uptake;Urease;Urethra;Urinary tract;Urinary tract infection;Urine;Urologic Diseases;Uropathogen;Uropathogenic E. coli;Virulence;Virulence Factors;virulence gene;Virulent;Visit;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Molecular mechanisms of uropathogenesis

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE  This project will study the mechanism by which CDCP1, a novel immunoregulator, regulates pathological T cell transmigration into the retina to induce autoimmune uveitis and evaluate CDCP1-targeted therapeutic approach for this blinding disease.

PI_NAMEs: LIN, FENG C (contact)

PROJECT_TERMS: Activated-Leukocyte Cell Adhesion Molecule;Active Immunization;Adoptive Transfer;Arrestins;Attenuated;Autoimmune Diseases;autoimmune pathogenesis;autoimmune uveitis;Biological Assay;Blindness;Blocking Antibodies;Blood-Retinal Barrier;CD6 antigen;cell motility;Cell surface;conditional knockout;cytokine;Cytoskeleton;Data;Development;Disease;efficacy evaluation;Endothelium;Epithelium;Event;extracellular;Extracellular Domain;Flow Cytometry;Genetic;Human;immunogenicity;immunoregulation;Impairment;In Vitro;in vivo;Infiltration;inhibiting antibody;insight;Interleukin-6;knock-down;Knock-out;Knockout Mice;Knowledge;Ligands;Mediating;migration;Monoclonal Antibodies;Mus;mutant;Myosin ATPase;nanobodies;new therapeutic target;next generation;novel;novel therapeutic intervention;Pathogenicity;Pathologic;Penetration;Permeability;Phosphorylation;Pre-Clinical Model;Process;Production;protein protein interaction;Proteins;Proteomics;Reagent;receptor;Reporting;Research;Retina;Role;selective expression;Signal Transduction;Stress Fibers;Structure of retinal pigment epithelium;Surface;Surface Plasmon Resonance;T cell infiltration;T cell regulation;T cell response;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;TFRC gene;Therapeutic antibodies;therapeutic target;Therapeutic Uses;Tight Junctions;Treatment Efficacy;Uveitis;Work

PROJECT_TITLE: Role of CDCP1 in the pathogenesis of autoimmune uveitis


NIH_SPENDING_CATS: Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Despite the acidic environment of the vagina – created by members of the vaginal microbiota – bacterial pathogens such as uropathogenic Escherichia coli (UPEC) can overcome acidification and colonize the vaginal space. Colonization of the vagina by UPEC can lead to urinary tract infection, or infection of the cervix and uterine horns, which can have adverse sequelae during pregnancy. This proposal will elucidate how UPEC uses its several acid resistance systems to establish a niche in the vagina and will explore the potential of overriding these acid resistance mechanisms as a prophylaxis against genitourinary tract infection.

PI_NAMEs: HADJIFRANGISKOU, MARIA  (contact)

PROJECT_TERMS: acid stress;Acids;Bacteria;Bladder;Cervix Uteri;colonization resistance;combat;Data;Deaminase;Deamination;enteric infection;Environment;Epithelial Cells;Escherichia coli;Escherichia coli Infections;fitness;Genitourinary system;Gnotobiotic;Gravid;Horns;Human;In Vitro;in vitro Model;in vivo;in vivo evaluation;Individual;Infection;Infection prevention;Intestines;Knowledge;Lactic acid;Lactobacillus;Lactobacillus delbrueckii;Life Style;Location;Maps;Measures;member;microbiota;microbiota composition;Modeling;Mus;mutant;novel;Nutrient availability;Output;pathogen;Pathogenesis;pathogenic bacteria;pathogenic Escherichia coli;Pathway interactions;Predisposition;Pregnancy;prevent;Prevention;Probiotics;Production;prophylactic;Prophylactic treatment;protective effect;Reaction;Regulation;Reporting;Resistance;resistance mechanism;response;Role;Sampling;Serine;Signal Transduction;stillbirth;System;Testing;Time;tissue culture;Toxin;Urinary tract;Urinary tract infection;urogenital tract;Uropathogenic E. coli;Uterus;Vagina;vaginal microbiota;Woman

PROJECT_TITLE: How E. coli Acid Response Mechanisms Breach Colonization Resistance in the Vagina

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-W(80)]


NIH_SPENDING_CATS: Aging;Cancer;Hematology;Rare Diseases

PHR: RELEVANCE Mitochondrial dysfunction is a root cause of developmental and metabolic disorders, cancer, and aging-related neurodegenerative diseases. While molecular chaperones provide the first line of defense against protein misfolding and aggregation, their function (or lack thereof) in disease states remains poorly understood. The broad and long-term research objective is to provide a molecular understanding of how mitochondrial protein quality control machines protect the organelle from damage and to exploit this information for the development of new therapeutic strategies against unmet human diseases.

PI_NAMEs: TSAI, FRANCIS T.F. (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adult;age related neurodegeneration;Alzheimer's Disease;Animals;Ankyrin Repeat;Antineoplastic Agents;Apoptosis;Applications Grants;Atherosclerosis;ATP phosphohydrolase;Binding;Binding Proteins;biological adaptation to stress;Biological Process;cancer cell;Cardiovascular Diseases;cell type;Cells;cerebral atrophy;Cessation of life;Clinical;Colorectal Cancer;Complex;Crista ampullaris;Cryoelectron Microscopy;Death Rate;Development;developmental disease;Disease;disease-causing mutation;Drug Targeting;Engineering;Family;Functional disorder;Health;Human;human disease;Huntington Disease;Hybrids;In Vitro;Inborn Errors of Metabolism;Life;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;member;Metabolic Diseases;microbial;misfolded protein;Missense Mutation;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Molecular;Molecular Chaperones;Molecular Conformation;Morphology;Mutagenesis;Mutation;N-terminal;Neonatal;neoplastic cell;Nerve Degeneration;Neutropenia;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nucleotides;Organelles;Outcome;Parkinson Disease;particle;Pathologic;Peptide Hydrolases;Peptides;Physiological;prevent;Process;protein aggregation;Protein Engineering;protein folding;protein misfolding;Proteins;Proteomics;proteostasis;Public Health;Quality Control;Reporting;Research;Resolution;Role;Stress;Structure;Structure-Activity Relationship;surveillance strategy;System;Technology;three dimensional structure;Time;unfoldase;X-Ray Crystallography

PROJECT_TITLE: Structure, Function, and Mechanism of a Mitochondrial Chaperone


NIH_SPENDING_CATS: Aging

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: The oral medication metformin is best known for its ability to treat diabetes, but more recently it has been found to have many additional health benefits such as inhibiting cancer growth and extending lifespan. Despite these well described effects, the ways that metformin promotes healthy aging and extends lifespan remain unknown. This project will determine the mechanisms by which metformin produces benefits on longevity with a focus on the drug’s effects on the cell’s powerhouse, the mitochondria, with the ultimate goal of exploiting metformin action to promote healthy aging in humans.

PI_NAMEs: SOUKAS, ALEXANDER A (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Adenosine Monophosphate;Age;Aging;aging process;aging related disease;Biguanides;Biological Models;Biology;Blood Glucose;Caenorhabditis elegans;cancer cell;Cell Nucleus;Cells;cellular targeting;combat;Complex;Data;Diabetes Mellitus;Elements;Event;extend lifespan;FRAP1 gene;functional genomics;Gene Expression;gene function;Generations;Genes;Genetic;genetic approach;genome editing;genome wide screen;Genomics;geroprotector;Geroscience;Goals;Growth;Health;Health Benefit;Health Promotion;healthspan;healthy aging;Human;human data;Hypoglycemic Agents;Incidence;innovation;interest;Knowledge;Laboratories;life span;Link;Longevity;Malignant Neoplasms;Mediating;member;Metformin;Mitochondria;model organism;Molecular;molecular imaging;Morbidity - disease rate;mortality;mTOR inhibition;Mus;Nuclear Pore Complex;Observational Study;Oral;Pathologic;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Phosphotransferases;Positioning Attribute;prevent;pro-aging;prospective;Protein Kinase;Proteomics;Publishing;response;Response Elements;restraint;Severities;Signal Transduction;Site;Suggestion;Therapeutic;therapeutic target;Tissues;Translating;Work

PROJECT_TITLE: Mitochondrial action of metformin in aging and longevity


ADMINISTERING_IC: DC

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurosciences;Nutrition;Vector-Borne Diseases

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project narrative  A mosquito’s sense of taste contributes to its decision to bite human hosts. The focus of the proposed work is to discover molecules that the fruit fly uses for taste, and build on these discoveries to uncover mechanisms underlying taste in the mosquito, Aedes aegypti, which spreads dengue, zika, yellow fever and other diseases that infect millions of people each year. The long-term goal it to use these insights to develop new strategies to control the spread of insect-borne disease.

PI_NAMEs: MONTELL, CRAIG  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Acids;Address;Aedes;Amino Acids;Area;Behavior;Behavioral Assay;Bite;Blood;Brain;Carboxylic Acids;Cells;Cellular biology;Chemicals;Consumption;Cues;Culicidae;Dangerousness;Data;Dengue;Dengue Fever;Detection;Development;Diptera;Discrimination;Disease;disease transmission;Disease Vectors;Distant;Drosophila genus;Drosophila melanogaster;egg;Electrophysiology (science);Essential Amino Acids;Esthesia;experimental study;Family;Fatty Acids;feeding;fly;Food;Food Preferences;G-Protein-Coupled Receptors;Genes;Goals;Growth;Homologous Gene;Human;Human Bites;Image;improved;information gathering;Ingestion;innovation;Insect Control;insect disease vector;Insecta;insight;Light;Malaria;Mammals;Mediating;member;Minerals;Modeling;Molecular;Molecular Genetics;Mosquito-borne infectious disease;Mutation;Neuroendocrine Cell;Neurons;Nutritional;Opsin;Pain;Parasites;Persons;Population;prevent;Production;Protons;receptor;receptor function;Research;Role;sensor;Sensory;Sodium Chloride;Source;Taste Buds;Taste Perception;Testing;Tongue;tool;TRP channel;vector mosquito;Virus;Work;Yellow Fever;ZIKA;zika fever

PROJECT_TITLE: Molecular genetics of gustatory detection

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Immunotherapy;Neurodegenerative;Neurosciences

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE Rather than treating the multiple pathologies of Alzheimer’s disease (AD) individually as is the current norm, we have designed a smart cell-based delivery (SmaCD) system to treat them all at once. Beyond AD, in the near future, we expect the SmaCD technology to be generally applicable across many additional disorders.

PI_NAMEs: ANDERSEN, JULIE KAY (contact);WALTON, CHASKA CARLOS

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: abeta oligomer;Academia;Aducanumab;Advisory Committees;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;American;Amino Acid Sequence;Amino Acids;Amyloid beta-Protein;Anti-Inflammatory Agents;Antibodies;Biological;Brain;Brain region;Budgets;cell type;Cells;chimeric antigen receptor T cells;Clinical Trials;Code;Combination Drug Therapy;Combined Modality Therapy;Complex;cost;Data;design;Development;Disease;Disease Progression;Disease remission;Dose Limiting;Drug Delivery Systems;drug development;Drug Interactions;drug synthesis;Engineering;European Union;Event;Excision;Exposure to;extracellular;Extracellular Protein;Failure;Future;Gene Expression Regulation;gene synthesis;Genetic Transcription;Gliosis;Human;human disease;Immune;Immunomodulators;immunoregulation;Immunotherapeutic agent;In Vitro;in vivo;Individual;Industrialization;Inflammation;Inflammatory;innovation;insight;Interleukin-10;Intervention;Investments;Laboratories;Legal patent;Mammalian Cell;mammalian genome;Mediating;Methods;Microglia;Modeling;Modern Medicine;Mus;neuroinflammation;neurotoxic;notch protein;novel;novel therapeutics;Organ;Pathologic;Pathology;Phagocytes;Phagocytosis;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Phase;Phase I Clinical Trials;pre-clinical research;Probability;Recovery;Regulatory T-Lymphocyte;Reporting;Research;response;Safety;Senile Plaques;Site;synthetic drug;System;tau Proteins;Technology;Testing;Therapeutic;Toxic effect;Transgenic Mice;Travel;Tropism;Validation

PROJECT_TITLE: A smart cell drug (SmaCD) delivery platform for mobile, targetable, and self-regulated combination therapy: a model project to rescue antibodies from Alzheimer's disease (AD) clinical trial failures

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Telehealth

PHR: Project Narrative The post-COVID landscape holds several advances in HIV care and treatment, chief among them the advent of telehealth and the FDA-approval of long-acting injectable antiretroviral therapy. It is critical to understand the impact of these innovations on retention in care and viral suppression and ensure that their use does not widen existing disparities. This K24 award will support Dr. Christopoulos in having protected time to mentor the next generation of researchers focused on improving engagement in care for persons living with HIV.

PI_NAMEs: CHRISTOPOULOS, KATERINA A (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Address;Adherence;Affect;antiretroviral therapy;Applications Grants;Area;care delivery;career;career development;Caring;Clinic;Clinic Visits;Clinical;clinical outcome assessment;Code;Communicable Diseases;Communities;COVID-19 pandemic;Data;Data Collection;data infrastructure;Dedications;Development;Development Plans;Disparity;doctoral student;drug resistance development;Ensure;Environment;Equity;ethnic minority;experience;Faculty;Failure;Feedback;Future;Goals;health disparity;health equity;Healthcare;HIV;Homelessness;housing instability;Impact evaluation;implementation science;improved;improved outcome;Infrastructure;Injectable;Injections;innovation;interest;International;Intervention;Interview;Learning;Measures;Medicine;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;minority investigator;Modality;Modeling;multidisciplinary;multilevel analysis;next generation;Outcome;pandemic disease;patient oriented;patient oriented research;Patient Outcomes Assessments;patient-clinician communication;Patients;Pattern;Perception;Persons;Physicians;pill;poor health outcome;post-COVID-19;Postdoctoral Fellow;pre-doctoral;programs;Provider;psychosocial;Qualitative Research;Quality of Care;racial minority;Research;research and development;Research Methodology;Research Personnel;Resources;Risk;Role;Roter;Sampling;shared decision making;Site;skills;skills training;social stigma;Social support;stay-at-home order;substance use;success;Surveys;Survival Analysis;System;Systems Analysis;telehealth;telehealth systems;Telephone;therapy development;Time;Training;training opportunity;treatment strategy;Underrepresented Minority;Urban Population;urban underserved;verbal;video visit;Viral;Visit;ward;Work

PROJECT_TITLE: Mentoring Patient-Oriented Research on Advances to Optimize Engagement in HIV Care

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: Newark

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative ! The hierarchical processing of acoustic information downstream from primary auditory cortex where it is integrated with other sensory inputs to support sound-driven decisions is largely unknown. The current project will address this issue by identifying an intercortical circuit from auditory to parietal cortex that displays the transformation of acoustic representations that ultimately supports auditory psychometric decisions and multisensory integration. The findings from this proposal will have novel and long-term clinical relevance regarding hearing-loss induced cognitive deficits that reflect impaired processing within higher cortical areas.

PI_NAMEs: YAO, JUSTIN DANIEL (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Address;Anatomy;Animal Model;Animals;Area;Attenuated;attenuation;Auditory;Auditory area;auditory pathway;Auditory Perception;auditory processing;awake;Award;Behavioral;Bilateral;career;Chalk;Characteristics;clinically relevant;Code;Cognitive deficits;Complex;Computer Models;Cues;Data;Decision Making;design;designer receptors exclusively activated by designer drugs;Detection;developmental plasticity;Discrimination;discrimination task;Environment;excitatory neuron;experience;extracellular;Genetic;Gerbils;Goals;hearing impairment;Human;Impairment;improved;In Vitro;Infusion procedures;Injections;innovation;Interneurons;Interview;Laboratories;light emission;Linear Models;Location;Measures;Mentors;Modality;multisensory;Muscimol;Nervous System;neural;neuromechanism;Neurons;neurophysiology;Neurosciences;New York;Non-linear Models;nonhuman primate;novel;Occupations;optogenetics;Parietal Lobe;Pathway interactions;Pattern;Performance;pharmacologic;Phase;Physiological;Physiology;Preparation;Process;programs;promoter;Psychometrics;Psychophysics;Publications;Research;Rodent;Role;Saline;Science;Sensory;sensory input;sensory integration;Signal Transduction;Site;skills;Slice;sound;Speech;Statistical Models;Stimulus;Surface;Task Performances;Techniques;Testing;Time;Training;Transfection;Universities;Viral;Viral Vector;Visual;Visual Cortex;visual information;wireless

PROJECT_TITLE: Sensory processing downstream of primary auditory cortex

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative Fast, accurate movement of the limbs is essential for performing many everyday activities. Disease and injury can often impair the ability to perform such movements, compromising quality of life for those affected. This proposal aims to uncover neural mechanisms responsible for generating fast and accurate movements, laying a foundation for improved diagnosis and treatment of movement disorders.

PI_NAMEs: NAGAMORI, AKIRA  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acceleration;Address;Affect;Afferent Pathways;Agonist;Animals;antagonist;Automobile Driving;Behavior;behavior observation;Behavioral Paradigm;Biophysics;Cerebellar Diseases;Characteristics;Clinical;Clinical Research;Computer Models;Data;Deafferentation procedure;Deceleration;defined contribution;Diagnosis;Disease;Elbow;Ensure;Environment;experimental study;Extensor;Feedback;Flexor;Forelimb;Foundations;Future;Genetic;genetic manipulation;Goals;Impairment;improved;Injury;insight;Interneurons;Joystick;kinematics;Knowledge;Lead;limb movement;Limb structure;Logic;Mediating;Methods;Modeling;Molecular Genetics;Motor;motor deficit;motor impairment;mouse model;Movement;Movement Disorders;Mus;Muscle;Nervous System;Nervous System Disorder;neural circuit;neuromechanism;Neurons;optogenetics;Pathway interactions;Pattern;Performance;Phase;presynaptic;Proprioception;Quality of life;recruit;Role;sensorimotor system;Sensory;Signal Transduction;Speed;Spinal;Stereotyping;Stroke;Structure;synaptic inhibition;System;Testing;theories;tool;Viral;Work

PROJECT_TITLE: Defining the contributions of proprioception to goal-directed reaching movements

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Antimicrobial Resistance;Autoimmune Disease;Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Inflammatory Bowel Disease;Microbiome;Prevention

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Despite increasing incidence of Clostridioides difficile infection (CDI) in inflammatory bowel disease (IBD) patients, the mechanism by which IBD confers susceptibility is unknown. The aim of this proposal is to define the role of the gut microbiota and the microbially derived secondary bile acids in conferring susceptibility and contributing to the severity of C. difficile infection during intestinal inflammation caused by IBD. The work in this proposal will directly impact public health through the development of novel non-antibiotic therapeutic and preventative interventions aimed at substantially reducing morbidity, mortality, and health care costs for IBD patients with CDI.

PI_NAMEs: WINSTON, JENESSA ANDRZEJEWSKI (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Acids;Antibiotics;Bile Acids;bile salts;Bioinformatics;career;Childhood;Clostridium difficile;Colitis;college;colonization resistance;Community-Acquired Infections;Complex;Data;dehydroxylation;Development;Disease;disease model;Ecosystem;enteric infection;enteric pathogen;experience;Funding;General Population;Goals;gut inflammation;gut microbiome;gut microbiota;Health Care Costs;host-microbe interactions;Hydrolase;Immune;Immune response;Incidence;Infection;Infectious Diseases Research;Inflammation;Inflammatory Bowel Diseases;innovation;insight;Interdisciplinary Study;Interleukin-10;Lactobacillus;Lead;Life Cycle Stages;Mediating;Mentors;metabolome;metagenome;Metagenomics;microbial;microbiota;Morbidity - disease rate;mortality;murine colitis;Mus;novel;novel therapeutic intervention;Ohio;Operon;Pathogenesis;Patients;Play;Predisposition;Preparation;prevent;preventive intervention;Preventive measure;Probiotics;Production;Public Health;Reaction;Recording of previous events;Research;Research Training;Risk;Risk Factors;Role;Scientist;Severities;Severity of illness;Shotguns;Spontaneous colitis;Supplementation;Testing;therapeutic development;Therapeutic Intervention;Training;Translational Research;treatment group;Universities;Ursodeoxycholic Acid;Veterinary Medicine;Wild Type Mouse;Work

PROJECT_TITLE: The impact of inflammation induced alterations to microbially derived bile acids on susceptibility and severity of Clostridioides difficile infection

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE Those who are blind or visually impaired suffer from an inability to transform visual information into behaviorally relevant representations to guide selection of appropriate actions. This project seeks to derive the algorithms for sensorimotor transformations that can guide technologies to restore visual-motor behaviors through neuroprosthetics. This project also seeks to uncover the underlying mechanisms for these algorithms that provide targets for restoring sensorimotor transformations in neurodegenerative diseases or neurodevelopmental disorders.

PI_NAMEs: VON REYN, CATHERINE R (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Afferent Neurons;Algorithms;Anatomy;Animals;Behavior;Behavioral;behavioral response;Biological;biophysical model;Biophysical Process;Biophysics;blind;cell type;Cells;Code;combinatorial;Computer Models;Data;Development;Drosophila melanogaster;Electrophysiology (science);Environment;Genetic;Grant;Individual;insight;Invertebrates;Ion Channel;knock-down;Knowledge;Link;Location;Maps;Methods;Modeling;Molecular;Motor;motor behavior;Motor output;neural;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;neuroprosthesis;Neurosciences;Optic Lobe;optogenetics;Outcome;Output;Pathway interactions;Pattern;Play;Population;presynaptic;Process;programs;Property;Research;Resolution;response;RNA Interference;Role;Sensory;sensory processing disorder;Shapes;Stimulus;Synapses;System;Technology;Testing;Validation;Visual;Visual impairment;visual information;visual motor;visual stimulus

PROJECT_TITLE: Neural algorithms underlying diversity in visual feature integration

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Rare Diseases;Tuberous Sclerosis

ORG_CITY: BERKELEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative Learning is central to behavioral therapies for autism spectrum disorder (ASD). Differences in learning may also underlie the rigid and repetitive behaviors that often manifest in behavioral inflexibility in people with ASD. Therefore, it is of great interest to understand how learning and behavioral flexibility and associated neural functions are altered by autism risk genes.

PI_NAMEs: WILBRECHT, LINDA E (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Affect;Area;arm;autism spectrum disorder;autism symptoms;Axon;Basal Ganglia;Basic Science;Behavior;Behavior Therapy;Behavioral;Biological;Calcium;Cognitive;cohort;Complex;Corpus striatum structure;Cues;Data;density;Diagnosis;diagnostic criteria;Discrimination;Dopamine;Dorsal;DRD2 gene;Electrophysiology (science);endophenotype;Evaluation;experimental study;Fiber;flexibility;FRAP1 gene;gain of function;Gene Mutation;Genes;Genetic;Genotype;high reward;Human;human subject;imaging modality;in vivo;in vivo imaging;individuals with autism spectrum disorder;interest;Intervention;learned behavior;Learning;loss of function;Mediating;model of autism spectrum disorder;Modeling;motor learning;Mus;neural;neural correlate;Neurobiology;Neurodevelopmental Disorder;Neurons;Neurophysiology - biologic function;Neurosciences;neurotransmission;Olfactory Learning;Outcome;Pathway interactions;Patients;Pattern;Phase;Phenotype;Photometry;Preparation;Probability;Psychological reinforcement;repetitive behavior;Research;Reversal Learning;Rewards;risk variant;sex;Side;Signal Transduction;Slice;social communication;structural imaging;Synapses;System;Testing;Therapeutic;Therapeutic Intervention;Training;Translating;transmission process;TSC1 gene;Tuberous Sclerosis;tuberous sclerosis patients;Update;Work

PROJECT_TITLE: Strengths and weaknesses in learning in mice with ASD risk genes

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: LINCOLN

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Project Narrative Our research develops new algorithmic approaches for infectious disease testing. These approaches will lead to quicker reporting of test results and to increases in the number of people who can be tested. Our research also develops modeling methods so that public health ofﬁcials can learn from the data generated by these testing approaches.

PI_NAMEs: BILDER, CHRISTOPHER R (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: 2019-nCoV;Algorithms;American;antiretroviral therapy;Area;Award;Bacteria;Biological Assay;Biometry;Blood Donations;Blood Tests;Centers for Disease Control and Prevention (U.S.);Chlamydia;Chlamydia trachomatis;Classification;Clinical;Communicable Diseases;coping;Country;COVID-19 assay;COVID-19 pandemic;Data;Detection;Disease;disorder risk;future pandemic;Goals;Gonorrhea;Government Officials;Grant;Health Professional;Hepatitis B;HIV;HIV Seropositivity;Hour;Individual;innovation;Journals;Laboratories;Lead;Learning;learning strategy;Measures;Medical;member;Methodology;Methods;Modeling;multiplex assay;Mycoplasma genitalium;Neisseria gonorrhoeae;New York;Normalcy;pandemic disease;Paper;pathogen;Persons;Play;practical application;Probability;Procedures;Public Health;Publishing;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;Response Latencies;Role;Scientist;screening;Sexually Transmitted Diseases;Specimen;statistical learning;Stream;Test Result;Testing;Time;tool;Treatment Failure;United States National Institutes of Health;Universities;viral detection;Virus;virus testing;web app;West Nile;Work

PROJECT_TITLE: Group testing for infectious disease detection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(02)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE There are racial disparities in birth mode among women with a prior cesarean, with Black women more likely to have unplanned repeat cesareans compared to White women, potentially contributing to higher rates of maternal morbidity for Black women. The proposed study will examine how hospital characteristics and processes of care shape racial disparities in birth mode among women with a prior cesarean. Results will contribute to a better understanding of the circumstances associated with labor after cesarean ending in cesarean delivery, and help to identify potential interventions to improve the quality of care for women with a prior cesarean.

PI_NAMEs: ATTANASIO, LAURA B (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Accounting;Address;Atopobium vaginae;Birth;Black race;black women;Caring;Cesarean section;Characteristics;Communication;Data;Decision Making;Disparity;disparity reduction;Educational process of instructing;ethnic disparity;experience;fetal;Goals;Healthcare;high risk;Hospitals;improved;Individual;Intervention;Interview;Joints;Labor Dystocia;Massachusetts;maternal morbidity;Measures;Medicaid;Medical;member;Methods;Midwife;Morbidity - disease rate;Outcome;Perception;Perinatal;Perinatal Care;Population;Process;Provider;public health priorities;Qualifying;Quality of Care;Race;racial difference;racial disparity;Research Personnel;Risk;Risk Factors;Rural;severe maternal morbidity;Shapes;Structure;success;Testing;Vaginal Birth after Cesarean;Vaginal delivery procedure;Variant;Vital Statistics;White Women;Woman;women's outcomes;Work

PROJECT_TITLE: Hospital quality, processes of care, and racial disparities in birth mode for individuals with a prior cesarean

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE The continuous activation of certain immune sensors called Toll-like receptors (TLR7 and TLR9) and the production of pro-inflammatory signaling proteins, such as type-I interferons (IFN-I), drive the pathogenesis of many autoimmune conditions. Recent evidence has established that a poorly-characterized protein in immune cells, called SLC15A4, exerts control over these processes. The goal of this application is to develop inhibitors for and assess the therapeutic potential of SLC15A4 in order to create a new path for the treatment of autoimmune disorders.

PI_NAMEs: PARKER, CHRISTOPHER G (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Adaptive Immune System;Address;Autoantibodies;Autoimmune;Autoimmune Diseases;autoimmune inflammation;autoimmune pathogenesis;B-Lymphocytes;Binding;Biochemical;Biology;CCL21 gene;Cells;Chemicals;chemoproteomics;Clinical;Collaborations;Crohn's disease;cytokine;Dedications;Dendritic Cells;Detection;Development;Disease;disease model;Endosomes;Environmental Risk Factor;Evaluation;Event;Foundations;Functional disorder;Future;Gene Family;Genetic;genetic approach;Genetic study;Goals;Hematopoietic;Homeostasis;Human;human disease;Immune;Immune response;Immune System Diseases;immunogenic;Immunology;Impairment;improved;in vivo;in vivo Model;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune System;innovation;insight;Interferon alpha;Interferon Type I;Interferons;Intervention;Invaded;Investigation;Knowledge;Lead;Ligands;loss of function;Lupus;lysosomal proteins;Macrophage;Mass Spectrum Analysis;Mediating;member;Membrane;Metabolic;Methodology;Molecular;mouse model;Mus;novel;novel strategies;Nucleic Acids;pathogen;Pathogenesis;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Physiological;Process;Production;protein function;protein protein interaction;Proteins;Proteomics;Reporting;Role;sensor;Series;side effect;Signal Induction;Signal Transduction;Signaling Protein;Site;Small Inducible Cytokine A21;small molecule;solute;stem;Systemic Lupus Erythematosus;Therapeutic;therapeutic target;TLR7 gene;TNF gene;Toll-like receptors;tool;Virus Diseases

PROJECT_TITLE: Chemoproteomic-Enabled Strategy to Study SLC Transporter Roles in Inflammation

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Digestive Diseases;Genetics;Human Genome;Neurosciences;Pediatric

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Public Health Relevance Statement  The enteric nervous system (ENS) is a critical part of the peripheral nervous system that controls gut motility and other functions. Abnormal development of ENS leads to life threatening disorders like Hirschsprung’s disease. Our results will provide important clues regarding mistakes that may lead to birth defects in the ENS.

PI_NAMEs: BRONNER, MARIANNE  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Antibodies;Birds;Brain;Burn injury;Cell Differentiation process;Cells;Central Nervous System;Chick;cholinergic;Colon;Compensation;Congenital Abnormality;Congenital Megacolon;CRISPR/Cas technology;Data;Defect;Development;Disease;Embryo;Enteral;Enteric Nervous System;enteric neuropathy;Environment;experimental study;fluorophore;Gastrointestinal Hormones;Gastrointestinal Motility;Gastrointestinal tract structure;Gene Expression Profile;Genes;Genetic Transcription;Genome;Genomic approach;Genus Alpharetrovirus;gut colonization;hatching;healing;hindbrain;Hindgut;Hormone secretion;Human;In Situ;Individual;insight;Interspecific Recombination;Intestines;Knowledge;Label;Length;Life;loss of function;Mediating;migration;Modernization;Motility;Motor Neurons;Neck;Nervous System control;neural;Neural Crest;Neural Crest Cell;Neural tube;Neuroglia;Neuronal Differentiation;Neurons;novel;Patients;Peripheral Nervous System;Plasmids;Population;Primitive foregut structure;Process;programs;Proliferating;public health relevance;Publishing;Quail;Retroviridae;Role;Sampling;single-cell RNA sequencing;Somites;Sorting;SOX21 gene;SOX4 gene;Tail;Techniques;Testing;Time;time use;transcription factor;Tyrosine 3-Monooxygenase;Umbilicus

PROJECT_TITLE: Contribution of the sacral neural crest to the peripheral nervous system of the post-umbilical gastrointestinal tract

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PUBLIC HEALTH RELEVANCE STATEMENT This proposal aims to develop novel targeted therapeutics against blood cancer, with a focus on peripheral T cell lymphoma that affect thousands of patients annually in the United States. If successful, it will significantly advance our understanding of the progression and malignant transformation of blood cells, and provide new opportunities for developing therapeutic tools for the treatment of lymphoma and other types of tumors sharing the similar genetic defects in epigenetic and GTPase signaling pathways.

PI_NAMEs: ZHOU, YUBIN  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acceleration;Address;Affect;Animal Model;antitumor effect;B-Cell Lymphomas;Bioinformatics;Biology;Biometry;Blood Cells;Calcineurin;Calcineurin inhibitor;cancer cell;Caring;CD4 Positive T Lymphocytes;Clinical;Clinical Management;Clinical Trials;clinically relevant;Combined Modality Therapy;design;Diagnosis;Disease;DNA Methylation;drug candidate;Drug usage;effective therapy;efficacy evaluation;Epigenetic Process;Etiology;Family member;FDA approved;FK506;Gene Modified;Genes;Genetic;Genomics;Genotype;Goals;Guanosine Triphosphate Phosphohydrolases;Hand;Hematologic Neoplasms;Hematopoietic Neoplasms;Homologous Gene;Hot Spot;Human;Immunoblastic Lymphadenopathy;improved;in vivo;Intervention;Lead;Lesion;Lymphoma;Lymphomagenesis;Malignant - descriptor;Malignant Neoplasms;Mature T-Lymphocyte;Modification;Molecular;mouse model;Mus;mutant;Mutation;Natural Killer Cells;new therapeutic target;novel;nuclear factors of activated T-cells;Oncogenic;Pathogenicity;Pathway interactions;Patients;Penetrance;Peripheral;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pilot Projects;Play;Positioning Attribute;pre-clinical;Preclinical Testing;Progression-Free Survivals;Property;Protac;public health relevance;Records;rho;rho GTP-Binding Proteins;RHOA gene;screening;Signal Pathway;Signal Transduction;small molecule;Somatic Mutation;Structure;Subgroup;synergism;System;T-Cell Lymphoma;T-Cell Transformation;T-Lymphocyte;Tacrolimus;targeted treatment;Technology;Test Result;Testing;Therapeutic;therapeutic development;therapy design;three dimensional structure;tool;transcription factor;Transcription Factor AP-1;Transgenic Mice;translational study;tumor;Tumor Burden;tumor growth;United States

PROJECT_TITLE: Selective targeting of a Rho GTPase mutant for peripheral T cell lymphoma treatment


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The cDC1 subset is critical for immune responses to viruses and tumors, and proposals to expand this subset therapeutically by Flt3L administration rely on an untested presumption that such expanded populations can function normally. Our preliminary evidence indicates that FL3L expansion of cDC1 proceeds by a different genetic pathway than homeostatic cDC1 development. Thus, the goal of this application is to determine how cDC1 normally develop, how Flt3L treatment bypasses normal genetic requirements for cDC1 development, and whether Flt3L-induced cDC1 can operate in vivo in the same way as normal cDC1.

PI_NAMEs: MURPHY, KENNETH M (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Ablation;adaptive immune response;Address;Antigen-Presenting Cells;Antigens;ATAC-seq;Binding;Bypass;CCAAT-Enhancer-Binding Proteins;CD8-Positive T-Lymphocytes;Cell Physiology;Cell surface;Cells;Chimeric Proteins;ChIP-seq;Clinical;Complex;CRISPR/Cas technology;Critiques;Cross Presentation;Data;Dendritic Cells;Dependence;design;Development;effector T cell;Elements;Enhancers;Epitopes;Exhibits;Family member;FLT3 gene;FLT3 ligand;Gene Targeting;Generations;Genes;Genetic;Genetic Transcription;Germ Lines;Goals;granulocyte;Homeostasis;Human;Immune response;Immunity;In Vitro;in vivo;Infection;interest;Literature;Lymphoid Tissue;Macrophage;Methods;MHC antigen;Molecular;monocyte;Mus;Myelogenous;Myeloid Cells;novel;Output;Pathway interactions;Peptide Initiation Factors;Peptides;Population;Process;Production;progenitor;Proteins;Publishing;Reagent;Reporter;Reporting;Repression;response;Role;Route;Signal Induction;Signal Transduction;Site;Specific qualifier value;stem cells;Suggestion;System;T cell response;T-Cell Activation;Testing;Therapeutic;Time;tool;transcription factor;tumor;Tumor-Derived;uptake;Vaccines;Viral;Virus;Work

PROJECT_TITLE: Molecular Basis of cDC1 Development

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]