ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: JACKSON

ORG_NAME: JACKSON STATE UNIVERSITY

ORG_STATE: MS

PHR: PUBLIC HEALTH RELEVANCE This proposal aims to establish the Jackson State University (JSU) - Mississippi Delta Research Center of Excellence for Maternal Health to address preventable maternal mortality, decrease severe maternal morbidity, and promote maternal health equity in partnership with the Mississippi Delta community. This research center will conduct two multi-layered research projects utilizing community health partners, inclusive of an extensive research training program for early-stage investigators, to address the interpersonal and structural factors that affect maternal outcomes. By establishing an equal partnership with the community in all parts of the process, we envision that this research center will overcome structural and interpersonal barriers to high-quality, culturally competent postpartum maternal care and ultimately improve maternal morbidity and mortality for women residing in the Mississippi Delta.

PI_NAMEs: POLK, DR BERYL ;SHAW, MARY D (contact);TIEMEIER, HENNING

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Affect;barrier to care;black women;Caring;Centers of Research Excellence;Clinical;clinical practice;Collaborations;Communication;Communities;Community Health;Community Health Aides;Community Networks;Community Participation;community partners;community partnership;Community Practice;Community Workers;cultural competence;Data;design;Dimensions;Disparity;effectiveness evaluation;Ensure;Environment;ethnic disparity;Ethnic Origin;evidence base;experience;Faculty;Family;Fostering;geographic disparity;Goals;Health;health disparity;health inequalities;health literacy;Healthcare;Home visitation;Hospitals;implementation science;improved;Inequity;Infant Care;innovation;Internet;Intervention;Knowledge;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;maternal outcome;member;Mental Health Services;Mentors;Mississippi;mortality;Mothers;patient oriented;Patient Participation;Patients;peer;Personal Satisfaction;Population;Postdoctoral Fellow;postpartum health;Postpartum Period;Postpartum Women;Pregnancy;Pregnant Women;preventable death;Process;program dissemination;programs;Provider;Public Health;public health relevance;Public Health Schools;Race;racial disparity;Recording of previous events;Research;research and development;research data dissemination;Research Personnel;Research Project Grants;Research Training;Resistance;Resources;Rights;Rural;severe maternal morbidity;skills;Social Work;socioeconomic disparity;structural determinants;success;Testing;Training;Training Programs;training project;Trust;United States;Universities;Voice;White Women;Woman;Women's mortality

PROJECT_TITLE: Delta Mississippi Center of Excellence in Maternal Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-F(71)R]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PI_NAMEs: POLK, DR BERYL  (contact)

PROJECT_TERMS: Address;Affect;American College of Obstetricians and Gynecologists;Area;Birth;Blood coagulation;Cardiovascular Diseases;Caring;Cause of Death;Centers of Research Excellence;Cessation of life;checkup examination;Child;Child Rearing;Childbirth;Chronic;Chronic Disease;Clinical;Communities;Community Health;Community Health Aides;Community Healthcare;Community Participation;community partnership;Computerized Medical Record;Consult;County;cultural competence;Data;Death Rate;depressive symptoms;Disease Management;Disparity;Early Intervention;Effectiveness;effectiveness evaluation;Elements;Emergency department visit;Emotional;evidence base;Evidence based program;experience;Face;feeding;Financial Support;follow-up;Gynecologist;Health;health disparity;health inequalities;Health Personnel;Healthcare;Hematology;High Risk Woman;Home;Home visitation;Homicide;Hospitalization;Hospitals;Hypertension;improved;Inequity;Infant Care;intervention program;Kidney;Knowledge;Life Cycle Stages;Maternal Health;Maternal health equity;Maternal Health Services;maternal morbidity;Maternal Mortality;maternal outcome;Measurable;Medical;member;Mental Health;Methods;Mission;Mississippi;Mothers;Newborn Infant;novel;Nurses;Observational Study;obstetric care;Outcome;Overdose;Patient Self-Report;Personal Satisfaction;Persons;Pharmaceutical Preparations;Population;postpartum care;Postpartum Period;Pregnancy;Pregnancy Complications;pregnancy related death;prevent;Process;programs;Psyche structure;public health relevance;Race;racial disparity;randomized trial;Recommendation;Research;Research Personnel;Research Project Grants;Research Training;Risk;satisfaction;Schedule;Series;Service delivery model;service utilization;severe maternal morbidity;Sleep;Social support;Social Work;stressor;structural determinants;Suicide;teenage mother;telehealth;Telephone;Text;Training Programs;trend;Trust;United States;Universities;uptake;Visit;Well in self;Woman;Women's Health;Women's mortality

PROJECT_TITLE: Community Care Implementation to Reduce Maternal Health Inequities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-F]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: SHAW, MARY D (contact)

PROJECT_TERMS: Access to Information;Address;adverse maternal outcomes;Advocate;Affect;Back;barrier to care;black women;Cardiovascular system;care coordination;Caring;Centers of Research Excellence;Child Rearing;Clinical;Clinical Services;Communities;community advisory board;community engagement;Community Health;Community Health Aides;community intervention;community-centered;Comprehension;Contraceptive Agents;cost;cultural competence;distrust;Educational process of instructing;Effectiveness;effectiveness evaluation;efficacy evaluation;empowerment;Environment;Event;experience;Family;Focus Groups;Health;health care availability;health care quality;health care service;health communication;health inequalities;Health Insurance;health literacy;Health Personnel;Health Services;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;high risk;Hospitals;Hypertension;Improve Access;improved;Incidence;Infection;Insurance;Interpersonal Violence;Intervention;Licensing;Life;low health literacy;Maternal Health;Maternal health equity;Maternal Health Services;maternal morbidity;Maternal Mortality;maternal outcome;Medical;member;Mental Health;Mission;Mississippi;oral communication;Outcome;Parents;Patient Self-Report;Patients;Perception;Persons;post pregnancy;postpartum care;postpartum health;Postpartum Period;Postpartum Women;Poverty;pregnancy related death;pregnant;Preventive service;Process;Provider;public health relevance;racism;reproductive;Reproductive Health;Research;Research Activity;Research Personnel;Research Project Grants;Research Training;Risk;satisfaction;Self Efficacy;service utilization;Services;severe maternal morbidity;skills;structural determinants;Substance Use Disorder;System;Techniques;Text;therapy design;Training Programs;Transportation;Trust;United States;Universities;Visit;Vocabulary;Woman;Women's mortality;Writing

PROJECT_TITLE: JSU- Mississippi Delta Research Center of Excellence for Maternal Health


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: Address;Affect;Assessment tool;Authorship;Caring;Centers of Research Excellence;Child;clinical practice;Collaborations;Communication;Communication Tools;Communities;community building;Community Health;Community Healthcare;Community Networks;community organizations;Community Participation;community partners;community partnership;Community Workers;cultural competence;Data;Decision Making;design;Development;disparities in morbidity;Disparity;dissemination strategy;Economics;effectiveness evaluation;Ensure;Environment;Equity;evidence base;Foundations;Future;Goals;health disparities in women;health literacy;Health Policy;Health system;Healthcare;Home visitation;Hospitals;implementation process;improved;Incidence;insight;Institution;Internet;Justice;Lactation;Leadership;Manuscripts;Maternal Health;Maternal health equity;Maternal Health Services;maternal morbidity;Maternal Mortality;maternal outcome;Medical;meetings;member;Mental Health;Mississippi;Modeling;mortality disparity;Mothers;Outcome;Patient Participation;Patients;Policies;postpartum health;Postpartum Period;preference;Process;programs;Provider;public health relevance;Publications;Race;Recording of previous events;Reporting;Research;research and development;Research Personnel;Research Project Grants;Research Training;Resources;Running;Services;severe maternal morbidity;Social Work;statistics;structural determinants;success;symposium;Training;Training Programs;Trust;Universities;Update;Voice;Woman;women's morbidity;Women's mortality;Work

PROJECT_TITLE: Community Partners


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Over the past years, high throughput multiplexed serological assays have become available, allowing to simultaneously quantify antibody responses against 100s and even 1000s of antigens, from a single sample. These novel technologies offer unprecedented opportunities to study the dynamics of multiple pathogens simultaneously reconstruct susceptibility profiles of populations and inform control interventions. The central theme of my research program is to develop robust and validated tools and analytic methods necessary to translate the promise of high throughput serology into mechanistic insights about pathogen dynamics.

PI_NAMEs: RODRÍGUEZ-BARRAQUER, ISABEL  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: analytical method;Antibody Repertoire;Antibody Response;Antigens;Birth;cohort;Collaborations;Communicable Diseases;Computer software;Country;Cross-Sectional Studies;Data;Data Analyses;Disease;disorder control;Epidemiology;Evolution;Goals;human pathogen;Immune;Immunologics;Individual;Infection;insight;Intervention;Methodology;Methods;Modeling;multiple data sources;new technology;open source;pathogen;Performance;Policy Maker;Population;Population Study;Predisposition;programs;Recording of previous events;Research;Research Personnel;Resources;response;Risk;Sampling;Serology;Serology test;Serum;simulation;Technology;Time;tool;Translating;transmission process;Validation;Work

PROJECT_TITLE: Uncovering the dynamics of human pathogens using high throughput multiplexed serological tools

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Rural Health;Social Determinants of Health;Women's Health Research

PI_NAMEs: TIEMEIER, HENNING  (contact)

PROJECT_TERMS: Address;Affect;Applied Research;Behavioral;Biological;Caring;Centers of Research Excellence;Clinical;clinical care;cohort;collaborative approach;Communities;community collaboration;Community Health;community partners;cultural competence;Developed Countries;Development Plans;disparities in women;Disparity;Educational workshop;Environmental Risk Factor;Equity;ethnic minority population;experience;Faculty;Fostering;Funding;Goals;Grant;health disparity;health outcome disparity;Health Personnel;Health system;health training;Healthcare Systems;Historically Black Colleges and Universities;improved;improved outcome;Individual;Inequity;innovation;Institution;Knowledge;Maternal and Child Health;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;maternal outcome;meetings;Mentors;Mississippi;Modeling;Morbidity - disease rate;mortality;Neighborhood Health Center;next generation;Outcome;outreach;Persons;population health;Postdoctoral Fellow;Postpartum Period;pre-doctoral;Pregnancy;Process;programs;public health relevance;Public Health Schools;Publications;racial minority population;Research;Research Personnel;Research Project Grants;Research Training;Resource-limited setting;Resources;Risk;Role;Rural;Rural Developments;Rural Population;rural underserved;Scientist;severe maternal morbidity;social determinants;social health determinants;social media;sociocultural determinant;socioeconomic disadvantage;statistics;structural determinants;System;Training;Training Programs;underserved area;underserved community;United States;Universities;virtual;Women's mortality

PROJECT_TITLE: Training Program


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Neurosciences;Nutrition;Obesity

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Cardiovascular mortality attributable to hypertension (HTN) has increased during the last decade, due in part to the escalating obesity epidemic. Exaggerated sympathetic nervous activity (SNA) and vasoconstriction are hallmark features of many cardiovascular diseases including obesity-associated HTN (Ob-HTN). The overall aim of this proposal is to 1) identify how sympathetic action potential patterns change in response to stress in healthy adults and Ob-HTN patients 2) to assess the impact of action potential patterns on mechanisms of vasoconstriction in healthy adults and in patients with Ob-HTN.

PI_NAMEs: HEARON, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Action Potentials;Adrenergic Agents;Adrenergic alpha-Antagonists;Adult;adult obesity;Age;alpha-adrenergic receptor;Animal Model;attributable mortality;blood pressure regulation;Cardiovascular Diseases;Cardiovascular system;Chronic;Data;Goals;Heart failure;High Prevalence;Human;Hypertension;hypertensive;Hypoxia;Individual;Investigation;Measures;Mediating;Metabolic Diseases;National Heart, Lung, and Blood Institute;neural patterning;neuropeptide Y;neurotransmission;neurovascular;new therapeutic target;Norepinephrine;novel therapeutic intervention;obese patients;Obesity;Obesity Epidemic;Participant;patient population;Patients;Pattern;Peripheral;pharmacologic;physiologic stressor;Physiological;Psyche structure;receptor;Recommendation;recruit;Reflex action;Research;response;Rest;Rodent Model;Signal Transduction;Sleep Apnea Syndromes;Stress;Testing;therapeutically effective;vasoconstriction;Vasoconstrictor Agents;working group

PROJECT_TITLE: Sympathetic neural patterns and transduction in obesity-associated hypertension

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Primary Health Care

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Individuals with Alzheimer's disease and related dementias are at risk for side effects and health risks from taking multiple medications. Deprescribing by reducing or stopping medications that are potentially inappropriate or unnecessary can improve health and well-being outcomes for this population and their care partners. The proposed research will refine and test a patient-centered and pragmatic intervention in which care partners of patients with dementia are provided with educational materials through the patient portal to engage them in deprescribing.

PI_NAMEs: BAYLISS, ELIZABETH A;GREEN, ARIEL  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adverse drug event;Affect;Alzheimer's disease related dementia;Behavior Therapy;Behavioral Symptoms;care delivery;Caregivers;Caring;Characteristics;Chronic;Clinic;Clinical;Clinical Pharmacists;Cluster randomized trial;Colorado;Communication;Community Physician;Consultations;Data;Dementia;dementia care;design;Drug Interactions;Drug Prescriptions;Educational Materials;Electronics;experience;Face;Family Caregiver;foster care;Frontline worker;Future;Goals;Health;Health system;Healthcare Systems;improved;improved outcome;Individual;Intervention;Interview;Lived experience;Measures;medication administration;Medication Management;Methods;Modeling;mortality;multi-component intervention;Nonpharmacologic Therapy;older adult;Outcome;Outcome Measure;Patient Care;patient oriented;patient portal;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;Pharmacists;Polypharmacy;Population;Pragmatic clinical trial;pragmatic intervention;Primary Care;primary outcome;Process;Property;Protocols documentation;psychological symptom;Public Health;Quality of life;randomized trial;Recommendation;Reporting;Research;Risk;Risk Taking;secondary outcome;side effect;Site;System;Testing;Time;Training;United States National Institutes of Health;uptake;usability;user centered design;Visit;Work

PROJECT_TITLE: eAlign: A Patient Portal-based Intervention to Align Medications with What Matters Most


ORG_CITY: SIOUX FALLS

ORG_NAME: AVERA MCKENNAN

ORG_STATE: SD

PHR: Maternal American Indian Rural Community Health Research Center of Excellence | M.A.R.C.H. PROJECT NARRATIVE The purpose of the Maternal American Indian Rural Community Health Research Center of Excellence (M.A.R.C.H.) is to provide a platform for researchers, tribal nations, rural communities and key stakeholders to engage in bidirectional communications on maternal health, in particular drivers of mortality and severe morbidity. All center components revolve around two populations with stark health disparities in our region – American Indian and rural residents. Novel mechanisms for improving access to care and creating a better understanding of barriers to and facilitators of accessing care feed into the overarching theme of the center and the projects proposed.

PI_NAMEs: ELLIOTT, AMY J (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Adoption;American Indians;Area;career;Caring;Centers of Research Excellence;Child Health;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Communities;community based research;community engagement;Community Health;community partners;community partnership;community research;Continuing Education;cultural competence;cultural health;design;Development;Educational Activities;Elements;Ensure;Equity;Evaluation;Goals;health disparity;Health Services Accessibility;Improve Access;improved;Infrastructure;Investments;knowledgebase;Lead;Leadership;literacy;Maternal Health;Maternal health equity;Maternal Mortality;meetings;member;Mentorship;Morbidity - disease rate;mortality;novel;Outcome;Policies;Population;Postpartum Period;Pregnancy;prenatal health;prevent;Procedures;Process;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Rural Community;rural dwellers;Rural Population;Services;severe maternal morbidity;skills;sound;Structure;Students;synergism;Training;training opportunity;Training Programs;tribal Nation

PROJECT_TITLE: Maternal American-Indian Rural Community Health (MARCH)


NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

PI_NAMEs: DEUTSCH, ARIELLE R. (contact)

PROJECT_TERMS: Accounting;Address;Advocate;Affect;American Indian community;American Indian Women;American Indians;Area;Automobile Driving;Biological Models;Childbirth;Collaborations;Communities;community based participatory approach;community collaboration;Community Health;Complex;Country;Data;Decision Making;disparities in morbidity;Disparity;disparity reduction;dynamic system;Ecosystem;Equity;Evaluation;experience;Failure;Geography;Goals;Health;health care quality;health care service utilization;health equity;Health Policy;Health system;Healthcare;Healthcare Systems;Human Resources;improved;in silico;Indigenous;Individual;Inequity;interest;Literature;low socioeconomic status;marginalized population;Maternal Health;maternal morbidity;Mediation;member;Minority Groups;Modeling;models and simulation;Network-based;Northern Plains;Outcome;Pathway Analysis;Pathway interactions;Patients;Perinatal;Perinatal Care;perinatal health;Persons;Policies;Population;postnatal period;predictive modeling;Pregnancy;prenatal;Process;Provider;Quality of Care;Recommendation;Research;Research Personnel;Reservations;Resource-limited setting;Resources;Role;Rural Community;Sampling;Science;Services;social health determinants;Structural Racism;success;Surveys;System;Testing;Translating;United States Public Health Service;Woman;Women Status

PROJECT_TITLE: Strengthening perinatal healthcare utilization and quality of care for Indigenous and low socioeconomic status women through systems change: integrating person, provider, and policy perspectives.


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Racial and Ethnic Minority Health Research;Rural Health;Women's Health Research

PROJECT_TERMS: Accountability;Adoption;American Indians;Area;Biological Models;Caring;Centers of Research Excellence;clinical practice;Clinical Trials;Clinical Trials Data Monitoring Committees;Communication;Communication Tools;Communities;community engaged approach;community engagement;Community Health;community involvement;community partners;community partnership;Electronic Mail;Elements;Ensure;Equity;Evaluation;experience;flexibility;Foundations;Goals;Health Services Accessibility;Healthcare;Home;improved;Information Dissemination;Infrastructure;Investments;Leadership;Maternal Health;meetings;member;Methods;Mission;Newsletter;Personal Satisfaction;Policies;Population;Positioning Attribute;Prenatal care;Privatization;Procedures;Process;programs;Research;Research Activity;Research Personnel;Research Project Grants;Rural Community;sound;Time;Training;Update;web page

PROJECT_TITLE: Community Partners Component


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

PI_NAMEs: ANGAL, JYOTI  (contact)

PROJECT_TERMS: American Indian community;American Indians;Area;career;Caring;Communication;Communities;community building;community engagement;Community Health;community partners;community partnership;Competence;cultural competence;Development;Discipline;Discipline of Nursing;Economics;Educational workshop;experience;Faculty;Goals;graduate student;health care availability;health training;Improve Access;improved;Individual;Knowledge;Learning;literacy;Maternal Health;Maternal Health Services;Medicine;member;Mentorship;Morbidity - disease rate;mortality;Participant;perinatal mental health;postnatal;Pregnancy;pregnancy related death;pregnant;Pregnant Women;programs;Public Health;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Research Training;Risk Reduction;Rural;Rural Community;skill acquisition;skills;social culture;Staff Development;Structure;Students;symposium;Time;Training;Training Activity;Training Support;Travel;Woman

PROJECT_TITLE: Training Component


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE This proposal focuses on the discovery, sequencing, and characterization of more complex structural variation that has been difficult to assemble as part of long-read sequencing efforts. The work will help complete our understanding of the full spectrum of human genetic variation and develop methods to better define complex patterns of normal variation and their relationship to rearrangements associated with rare pediatric disease.

PI_NAMEs: EICHLER, EVAN  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: 1q21;Adult;Age Years;Base Sequence;Child;Childhood;Chromosomes;Complement;Complex;Copy Number Polymorphism;Coupled;Data;de novo mutation;Disease;disorder risk;DNA;Event;Evolution;Frequencies;Future;Gene Frequency;Genetic;Genetic Diseases;Genetic Polymorphism;Genetic Variation;Genome;Genomic Segment;Genomics;Genotype;Goals;Haplotypes;homologous recombination;Human;human disease;Human Genetics;Human Genome;Human Genome Project;human pangenome;improved;Individual;insight;Location;Maps;Methods;Modeling;Mutation;nonhuman primate;Parents;Patients;Pattern;Phase;Population;Population Genetics;Property;rapid technique;Recurrence;reference genome;Research;Resolution;Resources;sample collection;Sampling;Single Nucleotide Polymorphism;Structure;success;Technology;telomere;Testing;Validation;Variant;whole genome;Work

PROJECT_TITLE: Sequence resolution of complex human genome structural variation

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: We propose a predoctoral training program that integrates basic neurosciences, engineering and computational education, along with basic and translational research. Our proposed program includes five research focus areas (Neural Instrumentation, Neuroimaging, Neural Data Sciences, Systems Neuroscience and Clinical Neuroengineering) and three educational tracks: Basic Neuroengineering, Clinical Neuroengineering and Translational Neuroengineering. To provide the diverse opportunities, we take advantage of our long-standing institutional culture that integrates engineering with medicine. We aim to recruit from the top trainee pool, expand our efforts to maintain diversity and provide access and opportunities to under-represented minority, and prepare the trainees for diverse scientific careers in basic research and translation via different educational streams and through continuous mentoring, oversight, and feedback.

PI_NAMEs: THAKOR, NITISH VYOMESH (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Training Programs

PROJECT_TITLE: Training Program in Neuroengineering


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Down Syndrome;Genetics;Hematology;Human Genome;Intellectual and Developmental Disabilities (IDD);Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Children with Down syndrome (DS), which occurs due to trisomy 21, have a 20-fold increased risk of acute lymphoblastic leukemia (ALL), but the basis for the increased risk of leukemia remains unclear, including the potential interplay between other DS phenotypic features and ALL susceptibility. This study will build upon our previous genome-wide association study, as well as our ongoing genomic profiling and phenotyping efforts, to: 1) perform a comprehensive analysis of heritable variation associated with risk of ALL in children with DS, with a focus on structural, rare, and chromosome 21 variants; and 2) conduct deep phenotyping of children with DS-ALL to identify the impact of DS-related phenotypes on leukemia susceptibility and outcomes. Findings from this study may lead to improved genetic testing and counseling strategies for children with DS, and insights into genes driving DS-ALL may guide development of targeted therapies to improve outcomes in this vulnerable and high-risk patient population.

PI_NAMEs: LUPO, PHILIP ;RABIN, KAREN R (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Acute Lymphocytic Leukemia;Alleles;Automobile Driving;Binding;Biology;CDKN2A gene;Cell Cycle;Cellular Assay;Cessation of life;Child;Childhood Leukemia;Chromosome 21;Chronic;Clinical;Clinical Trials Cooperative Group;cohort;Congenital Abnormality;Cytogenetics;Data;Development;dosage;Down's Syndrome;Enrollment;Epigenetic Process;Exhibits;Family;Gene Dosage;Gene Expression;Genes;Genetic;Genetic Counseling;genetic testing;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;genome-wide analysis;genomic profiling;Genomics;Germ Lines;Germ-Line Mutation;Health;Heritability;high risk;Immunophenotyping;improved;improved outcome;indexing;Inherited;insight;Letters;leukemia;lifetime risk;lymphoblastoid cell line;Medical Records;Molecular;Molecular Epidemiology;mortality;Outcome;patient population;Patients;Pattern;Pediatric Oncology Group;Phenotype;Predisposition;Proliferating;Protocols documentation;Questionnaires;Registries;Relapse;Resources;Risk;Risk Factors;Role;Sampling;Specimen;Structural Congenital Anomalies;Susceptibility Gene;targeted treatment;Testing;Toxic effect;transcription factor;transcriptome sequencing;transcriptomics;Treatment outcome;United States National Institutes of Health;Variant;variant of interest;whole genome

PROJECT_TITLE: Molecular epidemiology of acute lymphoblastic leukemia in children with Down syndrome

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Regenerative Medicine;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Chronic alcohol consumption is toxic for liver tissue and interferes with the balance of healthy repair and regenerative processes that maintain the tissue function. Our collaborative program is aimed at identifying the sites of action where alcohol use interferes with the recovery process and translate the results between animal models and human condition.

PI_NAMEs: BATALLER, RAMON ;VADIGEPALLI, RAJANIKANTH  (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: Affect;Alcohol consumption;alcohol effect;alcohol response;alcohol-related injury;Alcoholic beverage heavy drinker;Alcoholic Beverages;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Animal Model;Animals;Attenuated;Automobile Driving;Cell Communication;cell type;Cells;Characteristics;Chronic;chronic alcohol ingestion;Clinical;comparison control;Complement;Computer Models;cooking;cytokine;Data Set;Defect;desensitization;design;disease model;Equilibrium;Ethanol;Event;experimental study;Exposure to;Female;Food;Gene Expression;Genes;Genetic Transcription;genome-wide;Goals;Health;Heavy Drinking;Hepatocyte;Human;Impairment;improved;in vivo;Individual;Intervention;Lead;Liver;liver cell proliferation;liver function;liver injury;Liver Regeneration;liver repair;locked nucleic acid;male;Mediating;Meta-Analysis;Metabolic;MicroRNAs;Molecular;molecular subtypes;Monitor;multimodal data;Mus;Nature;network models;novel;Nuclear;Pathologic;Pathology;Patients;Pattern;Phase;Phenotype;Positioning Attribute;Predisposition;problem drinker;Process;Productivity;programs;Proliferating;Rattus;Recovery;regenerative;Regenerative capacity;Regenerative response;repaired;Research;Resistance;response;response to injury;Rodent;Rodent Model;severe injury;sex;single cell analysis;Site;Spatial Distribution;Structure;System;Testing;Tissue Model;Tissues;tool;Toxin;transcription factor;transcription regulatory network;transcriptomics;Translating;ultrasound;X-Ray Computed Tomography

PROJECT_TITLE: Ethanol Effects on the Transcriptional Regulatory Network in Liver Regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(04)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Kaposi's sarcoma-associated herpesvirus (KSHV) causes several types of cancer, including lymphomas and AIDS-associated malignancies. The atomic models of the KSHV portal-associated proteins, terminase, and envelope glycoproteins from this study will reveal protein-protein interactions at the level of specific chemical bonds and lead to a mechanistic understanding of genome packaging and membrane fusion—two steps in KSHV infection and spread. By targeting these interactions, this study will inform future development efforts for antiviral drugs against infections by KSHV and other herpesviruses.

PI_NAMEs: WU, TING-TING ;ZHOU, Z HONG (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;AIDS related cancer;Amino Acids;Anti-viral Agents;Artificial nanoparticles;Bacterial Artificial Chromosomes;Binding;cancer type;Capsid;Capsid Proteins;Cells;chemical bond;chronic infection;Complex;crosslink;Cryoelectron Microscopy;Cytomegalovirus;Data;design;Development;Disease;DNA;DNA Packaging;drug development;Endothelium;Etiology;Family;Funding;Future;gammaherpesvirus;Genome;glycoprotein structure;Glycoproteins;Herpesviridae;Herpesviridae Infections;high risk infant;HIV;Human;Human Herpesvirus 8;In Situ;Individual;Infection;inhibiting antibody;inhibitor;insight;interest;Interruption;Kaposi Sarcoma;Link;Lymphoma;Lytic;Lytic Phase;lytic replication;Malignant Neoplasms;Mediating;member;Membrane Fusion;Modeling;Molecular Conformation;Mucous Membrane;Multicentric Angiofollicular Lymphoid Hyperplasia;Mutagenesis;mutant;Nature;novel strategies;novel vaccines;oral lesion;particle;Pathogenesis;Patients;peptidomimetics;Pharmaceutical Preparations;primary effusion lymphoma;Principal Investigator;Production;programs;Prophylactic treatment;protein protein interaction;protein structure;Proteins;Proteomics;Publications;Publishing;rational design;receptor;reconstruction;Relaxation;Research;Resolution;Respiratory syncytial virus;Respiratory syncytial virus RSV F glycoprotein;Site;Site-Directed Mutagenesis;Skin;Structure;System;Technology;terminase;Testing;Therapeutic Intervention;Transfection;vaccine candidate;Vaccine Design;Vaccines;Vertebral column;Viral;Viral Genome;viral transmission;Virion;Virus;Virus Inhibitors;Visualization

PROJECT_TITLE: In situ atomic structures of the Kaposi's sarcoma-associated herpesvirus portal-terminase complex and glycoproteins

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: NARRATIVE  The Programming for Biology Course is an intensive course designed to give biologists the bioinformatics skills necessary to contribute to biological research via the use of computer programming for data organization and mining, and experimental design and analysis. The course combines formal lectures with extensive hands-on laboratories in which students solve a series of computational problem sets drawn from common scenarios in biology research and data management.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Address;analysis pipeline;Area;Back;Bioinformatics;bioinformatics tool;Biological;biological research;Biology;career;Code;comparative genomics;Complex;Complex Analysis;computational pipelines;computer program;computer scientist;Computer software;Computing Methodologies;Custom;Data;Data Analyses;data complexity;data exchange;data format;data management;data mining;Data Set;database schema;Dedications;deep sequencing;design;Distributed Databases;DNA Resequencing;Educational process of instructing;Educational workshop;Ensure;Environment;Exercise;experimental analysis;Experimental Designs;experimental study;Explosion;Exposure to;Faculty;Floods;Genetic Population Study;Genome;Genomics;Genotype;Goals;graduate school;graduate student;Home;Human;Individual;Institution;instructor;Investigation;Knowledge;Laboratories;laboratory curriculum;Laboratory Study;Language;large datasets;Learning;lecturer;lectures;Libraries;Life;Methodology;Methods;Mining;model organism;Modernization;Molecular Biology;next generation;petabyte;Population Genetics;Postdoctoral Fellow;Problem Sets;Professional Education;Programming Languages;programs;protein structure;Published Comment;Pythons;Research;Research Personnel;Research Training;scientific computing;Sequence Alignment;Series;skills;Software Engineering;Students;success;synergism;System;Techniques;Technology;Theoretical Biology;Thinking;Time;tool;Training;Training Programs;Transcript;transcriptomics;Variant;web-based tool;Work

PROJECT_TITLE: CSHL Programming for Biology Course

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: Newark

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative: Complex, time varying, patterns of neural activity are thought to give rise to all of the behavioral complexity that animals engage in. However, technical limitations have made it impossible to recreate these patterns de novo in vivo, and thus we poorly understand how these patterns causally drive different movements. In this proposal, we use a unique and novel technique to drive precise, multi-neuronal, patterns of activity in awake animals to understand what features of neural activity drive action and ultimately to understand neural population coding.

PI_NAMEs: OLDENBURG, IAN ANTON (contact)

PROGRAM_OFFICER_NAME: KIM, EUNYOUNG

PROJECT_TERMS: Action Potentials;Address;Animals;Area;awake;Behavior;Behavioral;Brain;Cell Nucleus;Cells;Code;Cognition;Communication;Complex;Corpus striatum structure;Dimensions;Electrophysiology (science);Etiology;experience;Fire - disasters;genetic approach;in vivo;Link;Methodology;Microscope;millisecond;Modeling;Modernization;motor control;Motor Cortex;Movement;multi-photon;Mus;Nervous System Disorder;neural;neural patterning;neural prosthesis;neuronal patterning;Neurons;next generation;novel;novel strategies;Optics;optogenetics;Pattern;Perception;Population;Reporting;Role;Specific qualifier value;System;Techniques;Testing;theories;Time;two-photon;vector;Work;Writing

PROJECT_TITLE: Editing Population Codes For Action

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-L (70)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative HIV is over-represented in substance using and criminal legal involved populations. While effective HIV prevention strategies exist, they are rarely developed in equal collaboration with people in jails, prisons, on community supervision, or following release, resulting in disparities in HIV and substance use related health outcomes. The short-term goal of the INTERACT (Using DesIgN jusTicE to impRove cArCeral health ouTcomes) Center is to improve representation and engagement of individuals with context expertise in the criminal legal system, HIV and substance use in research to illuminate key barriers to service access. The long-term goal is to improve health equity by co-creating programs, policies, and interventions that will be optimized by equal representation.

PI_NAMEs: BRINKLEY-RUBINSTEIN, LAUREN ;DAURIA, EMILY F (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Affect;AIDS prevention;Behavior;burnout;care delivery;Centers for Disease Control and Prevention (U.S.);Collaborations;Communities;community advisory board;community building;community collaboration;community engagement;community involvement;Community Psychology;Compensation;Criminology;Cultural Anthropology;deprivation;design;Development;Discipline of Nursing;Disparity;distrust;Education;Effectiveness;efficacy evaluation;Ensure;experience;feasibility testing;Funding;Future;Goals;Growth;Health;health care availability;health equity;Health Sciences;Health Services Accessibility;HIV;HIV risk;Human;human centered design;Imprisonment;improved;Incentives;Individual;Institution;Intervention;Jail;Justice;Leadership;Legal;Legal system;Lived experience;marginalization;marginalized population;member;Methodology;Modeling;multidisciplinary;Occupations;Outcome;Patients;peer;peer coaching;Personal Satisfaction;Persons;Pilot Projects;Policies;Population;Positioning Attribute;Preparation;Prevention strategy;Prisons;Process;programs;Public Health;Publishing;Race;Racial Equity;racism;Recording of previous events;recruit;Reporting;Research;Research Activity;Research Project Grants;research study;Research Training;Resources;Risk;Role;Science;service delivery;service gap;Social Work;substance use;Substance Use Disorder;substance use treatment;Supervision;syndemic;System;Testing;Training;training opportunity;Training Programs;treatment services;Trust;United States National Institutes of Health;Work

PROJECT_TITLE: The INTERACT ( Using DesIgN jusTicE to impRove cArCeral health ouTcomes) Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 GXM-E (J1)]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Microbiome;Neurosciences;Nutrition

ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

PHR: Project Narrative The biochemical transformation of our diets by the trillions of microorganisms that colonize our gut is essential for our health and fitness. Recent work indicates that our circadian clocks coordinate functions of our microbiomes with rhythmic feeding behaviors, however, the mechanisms that underlie coordination of our metabolism with the metabolic functions of our microbiomes are not well understood. Here we propose to mechanistically determine how circadian clocks synchronize animal and microbial metabolic activities to promote overall health and fitness.

PI_NAMEs: BROOKS, JOHN FRANCIS (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TITLE: The Circadian Clock Coordinates Animal and Microbial Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-A (70)]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative Over 50,000 people are incarcerated in New York state and 1-2% are estimated to be people living with HIV (PLWH), and substance use disorder (SUD) is highly prevalent among criminal- legal system (CLS)-involved people, with an estimated 70-80% of US jail detainees having a SUD and at high risk of relapse, overdose-related mortality and HIV infection post-release. The overall goal of this study is to evaluate the effectiveness of TechMPower, an intervention that bundles implementation strategies to increase delivery of evidence-based intervention (EBPs) to prevent adverse HIV-related (new infection, untreated HIV) and SUD-related outcomes (fatal and non-fatal overdose) among a sample of individuals (n=1125 ) in 15 New York State county jails. This study’s outcomes will fill vital gaps in knowledge regarding whether TechMPower can improve the health of incarcerated people with substance use disorder and HIV-related risk through tech-mediated EBP service delivery in jails with linkages to community-based care.

PI_NAMEs: EL-BASSEL, NABILA ;FRYE, VICTORIA  (contact);HUNT, TIMOTHY

PROJECT_TERMS: Address;Adoption;Age;AIDS prevention;behavioral outcome;care delivery;Caring;Case Management;Communities;community based care;Community Services;Complex;Continuity of Patient Care;cost;cost effectiveness;Cost Effectiveness Analysis;County;Data;design;Detection;disorder prevention;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness testing;effectiveness/implementation study;Epidemic;Equity;Ethnic Origin;Evaluation;Evidence based intervention;experience;Funding;Gender;General Population;Goals;Harm Reduction;healing;Health;health equity;Healthcare;high risk;HIV;HIV Infections;Human immunodeficiency virus test;Hybrids;implementation outcomes;implementation strategy;implementation study;Imprisonment;improved;Individual;Infection;Intervention;intervention delivery;Intervention Studies;Jail;Knowledge;Legal system;Maintenance;Maps;Mediating;member;Methods;Modeling;mortality;naloxone dispensing;New York;opioid use disorder;Outcome;Outcome Study;Overdose;overdose death;overdose education;Persons;Pharmaceutical Preparations;Phase;point of care;pre-exposure prophylaxis;Prevalence;prevent;Prevention;primary outcome;programs;Provider;provider intervention;Race;rapid testing;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;relapse risk;Research;Research Design;Research Personnel;response;Risk;Sampling;screening;self testing;service delivery;service providers;Services;sex;Site;skills;social stigma;Substance Use Disorder;success;Surveys;Technology;telehealth;Testing;therapy design;Training;uptake;web platform

PROJECT_TITLE: TechMPower: Advancing HIV/SUD Care and Service Delivery for People Involved in the Criminal Legal System


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Blindness affects 40 million people globally, severely impairing quality of life and leading to economic losses of $12.5 billion/annum in the US and $29 billion in developed economies worldwide. By delivering microstimulation currents to the brain via a visual prosthesis, researchers aim to restore functional vision in profoundly blind people. Our goal is to optimize the resolution and thereby the efficacy and interpretability of artificial vision generated by a neuroprosthesis.

PI_NAMEs: CHEN, XING  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Accommodation phosphene;Address;Affect;Area;Behavioral;Bilateral;Blindness;Brain;brain computer interface;Bypass;Characteristics;Clinical;Data;data-driven model;Economics;Electric Stimulation;Electrodes;Electrophysiology (science);experience;extrastriate visual cortex;Eye;Foundations;functional restoration;Generations;Goals;Image;Impairment;Letters;Light;Location;microstimulation;Modeling;Monkeys;Neurons;neuroprosthesis;Ocular Prosthesis;Optic Nerve;Pattern;Perception;Peripheral;Persons;Quality of life;Reporting;Research Personnel;Resolution;Retina;Sampling;sight restoration;spatiotemporal;time interval;Training;Utah;V1 neuron;V4 neuron;Vision;Visual;Visual Cortex;Visually Impaired Persons

PROJECT_TITLE: Understanding the principles of phosphene fusion via high-channel-count visual prostheses


ORG_DEPT: ORTHOPEDICS

PHR: PROJECT NARRATIVE Our work, indicating that fat is a source of systemic inflammation contributing to the loss of cartilage in articular joints, has shifted the historical paradigm that osteoarthritis is a wear and tear disease. We posit that the complex interorgan crosstalk between fat and musculoskeletal tissues is key to unlocking a mechanistic understanding of disease progression and pain. The goal of this proposal is to define whether cell signaling, cell migration, or the nervous system are facilitating fat-joint crosstalk to enable the development of first-in- class OA therapeutics targeting the multi-organ interface to improve whole-body health.

PI_NAMEs: COLLINS, KELSEY HELEN-MARIE (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Adipose tissue;Afferent Neurons;Aging;Body System;Cartilage;cell motility;Cells;Communication;comorbidity;Complex;Degenerative polyarthritis;Development;disability;Disease;Disease Progression;fat grafting;Fatty acid glycerol esters;Generations;Goals;Health;Histology;Image;Implant;improved;Individual;insight;Insulin Resistance;joint injury;Joints;Knee joint;Leptin;liver injury;Longevity;Mechanics;Mediating;Mediator;Modeling;mouse model;Mus;Musculoskeletal;Nervous System;Obesity;Organ;Pain;Pain management;Parabiosis;Pathogenesis;Pathologic;Pathology;Physical Function;Population;Positioning Attribute;response;Signal Transduction;Source;Symptoms;Systemic disease;systemic inflammatory response;Testing;therapeutic target;Tissues;tool;Work

PROJECT_TITLE: Unraveling Fundamental Mechanisms of Interorgan Crosstalk in Osteoarthritis


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE: Heparin induced thrombocytopenia (HIT) is an allergic reaction to a commonly used blood thinner (heparin) that causes life-threatening clots. It is becoming increasingly clear that the standard approach of using alternative blood thinners for HIT treatment does not prevent many complications. In this proposal, we are examining other approaches to dampen the allergic response by blocking inflammation.

PI_NAMEs: AREPALLY, GOWTHAMI M (contact);CINES, DOUGLAS BROCK;RAUOVA, LUBICA

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Allergic Reaction;allergic response;Alternative Complement Pathway;Amputation;Antibodies;Anticoagulants;Antigen-Antibody Complex;Antigens;Binding;Biological Assay;Biological Markers;Blood Coagulation Factor;Blood Platelets;cell injury;Cells;Coagulation Process;Complement;Complement 1q;Complement 3c;Complement Activation;complement pathway;Complement Receptor;Complement Stabilization;Complex;Data;Deposition;Disease;Endothelial Cells;Enzyme-Linked Immunosorbent Assay;Hemorrhage;Heparin;Heparin Binding;heparin-induced thrombocytopenia;Human;Immunoglobulin G;Impairment;Inflammation;inhibitor;insight;Intervention;Life;Liquid substance;Maximum Tolerated Dose;Measures;Mediating;Microfluidics;Modeling;monocyte;mortality risk;Mus;Names;neutrophil;novel;oligomycin sensitivity-conferring protein;Parents;Pathway interactions;Patients;PF4 Gene;Plasma;prevent;Property;public health relevance;Publishing;Reaction;receptor;Recurrence;Research;response;Serum;Signal Transduction;Students;Surface;Testing;Therapeutic;Thrombin;Thromboembolism;Thromboplastin;Thrombosis;thrombotic;undergraduate research;VWF gene

PROJECT_TITLE: Adrien Jacobs - Undergraduate Research Supplement 5R01-HL151730

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Rural Health;Social Determinants of Health;Substance Misuse

PHR: PROJECT NARRATIVE In light of the ongoing overdose crisis, we will build on prior research evaluating SHIELD, a public-health oriented police education program and structural HIV prevention intervention. We will collaborate with the behavioral health workforce in several rural settings with high burdens of substance use in Appalachian Kentucky to evaluate SHIELD for its implementation and effectiveness outcomes (including increasing referrals to medications for opioid use disorder). This intervention will be a critical step towards broader implementation and scale-up in aligning policing practices with public health to address both HIV and substance use disorder outcomes.

PI_NAMEs: BELETSKY, LEO ;CEPEDA, JAVIER  (contact);PITPITAN, EILEEN VIRTUSIO

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;AIDS prevention;animation;Appalachian Region;Area;Behavior assessment;behavioral health;burnout;cohort;Collaborations;Communities;community intervention;community planning;cost effectiveness;County;Data;design;Disease Outbreaks;Drug user;Economic Models;Education;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation study;effectiveness/implementation trial;Epidemic;Evaluation;evidence base;Evidence based intervention;Funding;Goals;Hand;Harm Reduction;Health;Health Personnel;Health Services;Hepatitis C virus;HIV;HIV Infections;HIV risk;implementation evaluation;implementation intervention;implementation outcomes;implementation process;implementation/effectiveness;Imprisonment;Incidence;Infrastructure;Interruption;Intervention;Justice;Kentucky;Knowledge;Law Enforcement;Letters;Life;Light;Longitudinal cohort;medical specialties;medication for opioid use disorder;meetings;member;Mexico;Modeling;mortality;National Institute of Drug Abuse;Needle Sharing;Needle-Exchange Programs;novel;Occupational;Occupational Safety;Outcome;outreach;Overdose;overdose death;peer recovery;Pharmaceutical Preparations;Pharmacotherapy;Phase;Police;Police officer;Policies;Population;prevent;prevention service;preventive intervention;programs;Public Health;Readiness;recovery services;referral services;Reporting;Research;Risk;Risk Factors;Role;Rural;rural setting;Safety;scale up;Science;Services;skills;Source;substance use;Substance Use Disorder;System;Time trend;tool;Trainers Training;Training;Translating;transmission process;treatment services;trial design;United States Dept. of Health and Human Services;viral transmission

PROJECT_TITLE: Project SHIELD: Police Education to Support Public Health in Kentucky


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Patient Safety;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Ending the HIV epidemic (EHE) requires improvement in HIV treatment (TREAT) and retention for people with HIV and increased HIV pre-exposure prophylaxis (PrEP) utilization (PREVENT) for people at risk for acquiring HIV. One highly impacted group that has been insufficiently engaged in these efforts is justice-involved people who use drugs. By building on existing partnerships (with justice, public health, HIV treatment and prevention, substance use disorder treatment providers, and people with lived experience), and adapting and testing a patient-centered approach (adding patient choice to a patient navigation intervention) this proposal has the potential to improve the PREVENT and TREAT pillars of the EHE plan and reduce HIV infections in this vulnerable population.

PI_NAMEs: KNIGHT, KEVIN ;NIJHAWAN, ANK ELISABETH;SPRINGER, SANDRA ANN (contact);STATON, MICHELE

PROJECT_TERMS: Address;Adoption;Adult;antiretroviral therapy;arm;care delivery;Caring;Clinic;Clinical;Collaborations;Communities;community advisory board;Community Health;Connecticut;Consent;cost;County;Data;Dedications;disorder prevention;Drug user;DSM-V;effectiveness-implementation RCT;effectiveness/implementation study;effectiveness/implementation trial;Eligibility Determination;Enrollment;Epidemic;epidemic preparedness;evidence base;General Population;Goals;Harm Reduction;health care delivery;Health Personnel;Health Services Accessibility;Health system;HIV;HIV Infections;HIV risk;HIV Seronegativity;HIV Seropositivity;Housing;Human immunodeficiency virus test;Hybrids;implementation cost;implementation evaluation;implementation outcomes;implementation strategy;improved;Incidence;Individual;Infrastructure;innovation;Institutional Review Boards;Interdisciplinary Study;Intervention;Justice;Lived experience;Measures;meetings;Methods;Mobile Health Units;Modeling;multidisciplinary;National Institute of Drug Abuse;Needs Assessment;novel;Opioid;Outcome;Overdose;Participant;participant enrollment;patient engagement;patient navigation;patient navigator;patient oriented;Patients;peer;Penetration;Persons;Phase;Pilot Projects;pilot test;point of care;Population;Populations at Risk;pre-exposure prophylaxis;prevent;Prevention;prevention service;primary outcome;Public Health;Randomized;Research;Resources;response;Risk;Risk Assessment;Risk Behaviors;secondary outcome;service delivery;Service delivery model;Services;shared decision making;Site;social;Standardization;substance use;Substance Use Disorder;System;telehealth;Test Result;Testing;Texas;therapy adherence;Time;Transportation;treatment services;trial comparing;Underserved Population;United States;Viral;Vulnerable Populations

PROJECT_TITLE: STOP (Shared decision making to Treat Or Prevent) HIV in Justice Populations


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Bioengineering;Breast Cancer;Cancer;Clinical Research;Genetic Testing;Genetics;Machine Learning and Artificial Intelligence;Prevention;Women's Health Research

ORG_CITY: BERKELEY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative Despite knowledge that age, germline mutations (e.g. BRCA1, BRCA2, or PALB2), and family history of cancer are all risk factors for breast cancer, understanding what makes one person more susceptible to this disease compared to another is not well known. We propose to leverage two remarkable discoveries we have made with our innovative microfluidic platform, mechano-Node-Pore Sensing (mechano-NPS) —breast epithelial cells from younger and older women have different mechanical properties, and cells from young women who are at very high risk of cancer because they carry a germline mutation appeared mechanically “older” than the women’s chronological ages—to develop a breast cancer susceptibility detection system, which will measure the “mechanical age” of a woman’s cells. Clinically useful genetic testing relies on a handful of known monogenic risk traits, but we hypothesize that emergent mechanical properties, measured from a few hundred cells, are a characteristic of the biology that underlies cancer susceptible states, even those that are polygenic or epigenetic in nature and are passed within a family but that have so far defied definition.

PI_NAMEs: LABARGE, MARK A;SOHN, LYDIA L (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, KRISTIN HEDGEPATH

PROJECT_TERMS: Acceleration;Age;age acceleration;Aging;Biological Clocks;Biology;Biomechanics;BRCA1 gene;BRCA2 gene;Breast;Breast Cancer Risk Factor;Breast Epithelial Cells;Cancer Detection;cancer initiation;Cell membrane;Cell Nucleus;Cell Surface Proteins;Cells;Cellular biology;Characteristics;Chronology;Cities;Classification;Clinical;Complex;Cytoskeleton;Data;design;Detection;detection platform;Devices;Diameter;Disease;Early Diagnosis;Educational process of instructing;Epigenetic Process;Epithelial Cells;Exhibits;experimental study;Family;Family Cancer History;Family history of;Funding;gene network;Generations;Genetic;Genetic Screening;genetic testing;genetic variant;Germ Lines;Germ-Line Mutation;high risk;High Risk Woman;High-Risk Cancer;Human;Immune;in silico;innovation;Intermediate Filaments;Knowledge;Machine Learning;machine learning classification;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Measures;mechanical properties;Mechanics;Microfluidics;Modeling;Molecular;molecular mechanics;molecular phenotype;Nature;new therapeutic target;non-genetic;older women;PALB2 gene;Pathway interactions;Patients;Persons;Phenotype;physical property;portability;Portraits;Predisposition;Property;Proteins;Publications;Publishing;response;Risk;Risk Estimate;Risk Factors;screening;Surface;System;Time;Tissues;tool;trait;Validation;Variant;virulence gene;Woman;Work;young woman

PROJECT_TITLE: Detection of Emergent Mechanical Properties of Biologically Complex Cellular States

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: NARRATIVE The obesity epidemic is one of the foremost public health challenges worldwide and is expected to significantly worsen over the coming decades. The goal of this project is to develop a patient-adherent therapeutic drug depot for individuals living with obesity to safely promote weight loss and prevent or reverse the progression of comorbidities. We propose to rationally develop a drug delivery system for administration once every 6 months that targets immune cells in adipose tissue, to develop imaging tools to monitor its biodegradation in individual subjects, and to analyze its impact on rodent models of obesity and comorbid type 2 diabetes, with particular focus on the dependence of efficacy on sex, menopause, and obesity origins of genetic predisposition or diet.

PI_NAMEs: SMITH, ANDREW MICHAEL (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Address;Adherence;Adipocytes;Adipose tissue;Adult;Animal Model;Animals;Atrophic;attenuation;biodegradable scaffold;Biodegradation;Biological;Biology;Blinded;Blood Chemical Analysis;Body fat;Body Weight;Body Weight decreased;cancer type;Cardiovascular Diseases;Caring;Cells;Chemistry;Chronic;Clinic;Clinical;clinical care;cohort;comorbidity;Conjugated Carrier;cytokine;Dependence;design;Dextrans;Diabetes Mellitus;diabetic;Diet;dietary;Disease;Distal;Dose;Drug Carriers;Drug Delivery Systems;Drug Monitoring;Drug Targeting;Eating;Endocrinology;Engineering;Excretory function;exosome;extracellular;FDA approved;Fluorescence;Foreign Bodies;Formulation;Frequencies;Gastroenterologist;Genetic;Genetic Predisposition to Disease;glucose tolerance;Goals;Healthcare Systems;Heart Diseases;Hematology;Histopathology;Homeostasis;Hormonal;Human;Hydrolysis;Hypertrophy;Illinois;Image;image translation;Imaging Device;imaging modality;Imaging Techniques;Immune;Immune Targeting;Implant;improved;in vivo;Incidence;Individual;Infiltration;Inflammation;Injectable;Intervention;Intraperitoneal Injections;Lead;lead candidate;lipid biosynthesis;Lipolysis;Macrophage;Magnetic Resonance;Magnetic Resonance Imaging;Maintenance;Malignant Neoplasms;Measures;mechanical properties;Menopause;Metabolism;Methods;mimetics;Modality;Modification;Monitor;mouse model;multidisciplinary;nanocarrier;nanomaterials;Non-Insulin-Dependent Diabetes Mellitus;non-invasive imaging;Obesity;Obesity Epidemic;obesity treatment;Outpatients;Pathogenicity;Pathology;Patient Compliance;Patients;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phenotype;Physiological;Play;Polysaccharides;PPAR alpha;pre-clinical;prevent;Process;Prodrugs;Public Health;Regimen;research clinical testing;response;Risk Factors;Rodent;Rodent Model;Role;severe COVID-19;sex;Shapes;side effect;small molecule therapeutics;Solubility;Spatial Distribution;Specialist;Stroke;System;targeted treatment;Technology;Testing;Therapeutic;Tissues;Toxic effect;Translating;translational study;treatment adherence;Treatment Failure;ultrasound;United States;Universities;Vertebral column;Visceral;Visit;Weight;Work

PROJECT_TITLE: Macrophage-Targeted Drug Delivery Depot for Obesity and Comorbid Type 2 Diabetes

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Contraception/Reproduction;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: NUTRITION

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative This research has enormous potential to impact public health by providing a simple, low-cost tool for assessing placentas and incorporating diagnoses into clinical care in the highly sensitive time for mother and newborn immediately following birth. Broad implementation of this software could contribute to improved knowledge of the placenta and better maternal/child health outcomes, as well as connecting more clinicians to the use of important placental diagnoses.

PI_NAMEs: GERNAND, ALISON D (contact);GOLDSTEIN, JEFFERY A;WANG, JAMES Z

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Address;adverse outcome;Algorithms;Artificial Intelligence;artificial intelligence model;Assessment tool;Biological Sciences;Birth;Birth Weight;Caring;Characteristics;Chicago;Child;Chronic Disease;Clinical;clinical care;Clinical Data;clinically significant;Computational Technique;Computer software;Computer Vision Systems;cost;Data;data mining;Data Set;design;Devices;Diagnosis;digital;digital imaging;Discipline of obstetrics;Engineering;Environment;Ethnic Origin;Event;Fetal Development;Fetus;Future;Gestational Age;Glean;Goals;Health;health of the mother;Healthcare;Hemorrhage;Hospitals;Image;improved;Income;Infant;Infection;Informatics;intraamniotic infection;Kidney;Knowledge;Life;Lighting;Link;Liver;Low income;Lung;Maternal and Child Health;mathematical model;Measures;Medical;Medical Informatics;Membrane;Morbidity - disease rate;Morphology;mortality;Mothers;multidisciplinary;neglect;Newborn Infant;novel;open source;Organ;Outcome;overtreatment;Pathologist;Pathology;Pathology Report;Patients;Photography;Placenta;Placenta Diseases;Placentation;Population;Pregnancy;Process;Protocols documentation;prototype;Public Health;Race;Research;Research Personnel;Resources;Retained Placenta;Risk;Scientist;screening;Sensitivity and Specificity;Sepsis;sex;Shapes;Site;software development;Software Validation;Standardization;Technology;Testing;Time;tool;Training;Uganda;Umbilical cord structure;Variant;Visual;Woman;Work

PROJECT_TITLE: Development of Software to Rapidly Assess Placenta Images at Birth

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative:  Despite many years of treatment with existing medicines for HIV (Human Immunodeficiency Virus) infection, HIV-infected cells survive in the blood and tissues (especially gut), and some continue to produce viral products (HIV RNA, protein, and/or viral particles), which cause inflammation, damage multiple organs, reduce life expectancy, and allow the virus to relapse when treatment is stopped. In this proposal, we will apply novel technologies to cells from people living with HIV to determine the viral products that are associated with inflammation, characterize the cells that produce viral products, investigate the mechanisms that determine whether an infected cell will produce viral products, and compare the efficacy of existing and new drugs that are designed to inhibit production of HIV RNA and viral particles. Findings from these studies will generate a wealth of new knowledge and may lead to new approaches aimed at curing HIV or improving the health of people living with HIV.

PI_NAMEs: HUNT, PETER W;YUKL, STEVEN A (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Affect;antiretroviral therapy;Blood;Body System;Cell Survival;Cells;Chromatin;Chronic;Circulation;Clinical;cohort;comparative efficacy;differential expression;Disease;DNA;Drug Design;Extravasation;Failure;Frequencies;Functional disorder;gag Gene Products;Genes;Genetic Transcription;Gut Mucosa;Health;HIV;immune activation;Immunologic Markers;improved;Incidence;Individual;Infection;Inflammation;Inflammatory;knockout gene;Knowledge;Lead;Life;Life Expectancy;Longitudinal cohort;Medicine;Membrane Proteins;microbial products;Morbidity - disease rate;mortality;multiple omics;New Agents;new technology;new therapeutic target;novel;novel strategies;novel therapeutics;Organ;Outcome;particle;Permeability;Persons;Pharmaceutical Preparations;Phenotype;Plasma;prevent;Production;prospective;protein expression;Proteins;Proteome;Proviruses;Publishing;reactivation from latency;Relapse;Research Personnel;RNA;RNA Splicing;Sampling;single-cell RNA sequencing;Site;small molecule;targeted agent;Testing;Tissues;Transcript;Transcription Initiation;transcriptome;Viral;viral rebound;Virion;Virus;Virus Replication

PROJECT_TITLE: Understanding and targeting the HIV-expressing reservoir to reduce immune activation

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JBS-A (J1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse

PHR: The Mobile-Enhanced Prevention Support (MEPS) Intervention is an evidence-based intervention to promote engagement in services for HIV, STD, and hepatitis C testing and prevention and for addressing substance use disorders during reentry for sexual and gender minority individuals. The proposed research hub will adapt MEPS for a broader population and test it in three California counties to evaluate both the intervention's effectiveness in varied settings and its implementation using an Implementation Science framework, with the goal of developing guidance for broad intervention scale up and sustainment. The hub will also engage stakeholders throughout the state and other hubs to field pilot studies related to HIV prevention during reentry in people who use drugs.

PI_NAMEs: HARAWA, NINA THAWATA (contact);MCCOY, SANDRA I

PROJECT_TERMS: Address;Adherence;Adoption;Affect;AIDS prevention;Area;arm;Authorship;Black Populations;Black race;California;Client;Common Core;Communication;Communities;community academic partnership;community engagement;comparison intervention;County;Data;data exchange;data sharing;design;disorder prevention;Drug user;Effectiveness of Interventions;effectiveness trial;effectiveness/implementation study;efficacious intervention;Elements;Employment;Enrollment;ethnic disparity;evidence base;Evidence based intervention;experience;Face;follow up assessment;future implementation;gender minority group;General Population;Geography;Goals;Guidelines;Hair;Harm Reduction;Hepatitis C;Hepatitis C virus;HIV;HIV risk;HIV/STD;Housing;Human immunodeficiency virus test;Hybrids;implementation framework;implementation science;implementation strategy;Imprisonment;Incentives;Individual;Inequity;Infrastructure;Injecting drug user;Institutional Racism;Intervention;Jail;Justice;Knowledge;Latino;Latino Population;lens;Los Angeles;Maintenance;Measures;men;men who have sex with men;Mental disorders;mobile application;Monitor;multimodality;National Institute of Drug Abuse;Needs Assessment;New Agents;Occupations;Outcome;Overdose;Participant;participant enrollment;Patient Recruitments;Patient Self-Report;peer coaching;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;Population;pre-exposure prophylaxis;Prevention;Prevention Research;Prisons;Process;Proctor framework;Production;programs;Provider;racial disparity;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recurrence;Reporting;Research;Research Design;Research Personnel;Resources;Risk;Risk Behaviors;sample collection;Sampling;scale up;screening;service utilization;Services;sex;Sexual and Gender Minorities;sexual minority group;Site;Social Network;social stigma;Substance Use Disorder;substance use treatment;successful intervention;System;Tenofovir;Testing;therapy design;tool;Training;transgender women;transmission process;treatment arm;trial design;uptake;virus testing;web site;Work

PROJECT_TITLE: California Hub for HIV/STI/SUD Prevention Research with Reentry Populations


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative  HIV and substance use disorders are highly prevalent among people involved with the criminal legal system and multiple barriers complicate access to medical care in the period following incarceration. Interventions that address these barriers are critical to ending the HIV epidemic. The goal of this proposal is to evaluate a comprehensive, person-centered model of post-incarceration care for people with and at risk for HIV that uses peers with lived experience of incarceration to assist with linkage and engagement in medical care and substance use disorder treatment, community based- organization partnerships to meet unmet social needs, and decentralized medical care to address barriers to access.

PI_NAMEs: AKIYAMA, MATTHEW  (contact)

PROJECT_TERMS: Address;Adherence;arm;Attention;care delivery;care systems;Caring;Case Management;Client;Clinic;Clinical;Clinical Services;Collaborations;Communication;Communities;community advisory board;community organizations;community reentry;Complex;Continuity of Patient Care;cost effective;cost effective intervention;cost estimate;Counseling;Data;Decentralization;economic value;effectiveness/implementation trial;Elements;Employment;Ensure;Environment;Epidemic;evidence base;experience;Face;Fortune;Funding;Goals;Health Care Costs;Health Care Sector;health equity promotion;health organization;Health system;HIV;housing instability;Hybrids;implementation barriers;implementation protocol;implementation research;implementation strategy;Imprisonment;improved;improved outcome;Individual;innovation;Intervention;Jail;Knowledge;Legal;Legal system;Link;Lived experience;Location;Logic;Medical;member;Mental Health;Modeling;Motivation;multi-component intervention;multi-site trial;multimodality;New Jersey;Outcome;Participant;patient engagement;peer;person centered;Persons;Phase;Philadelphia;Pilot Projects;Policy Maker;pre-exposure prophylaxis;Preparation;Process;Productivity;Provider;Quality-Adjusted Life Years;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Relapse;Research;Resources;Risk;safety net;Services;Site;social;social stigma;Social Work;Societies;standard care;standard of care;stem;Substance Use Disorder;success;Telemedicine;Testing;Text Messaging;Time;transmission process;trustworthiness;uptake;Viral

PROJECT_TITLE: A Decentralized, Status neutral, Stakeholder-engaged, post-incarceration intervention for people with and at risk for HIV


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: MOUNTAIN VIEW

ORG_NAME: ASTRAEA THERAPEUTICS, LLC

PHR: Narrative  The Administrative Supplement requests support for costs arising from unanticipated expenses to conduct preclinical studies required by the FDA and be able to continue our clinical trial of the novel smoking cessation pharmacotherapy on our current active U01 grant U01DA054882. The required preclinical studies were not expected and thus not planned for but are now necessary to preserve the overall impact of the project consistent with its originally approved Specific Aims and overall objectives.

PI_NAMEs: PERKINS, KENNETH ALAN;ZAVERI, NURULAIN T (contact)

PROGRAM_OFFICER_NAME: WANG, JIA BEI

PROJECT_TERMS: Address;Administrative Supplement;Animals;Blood Pressure;Cannulations;Cardiovascular system;Clinical;clinical development;Clinical Protocols;Clinical Trials;Conscious;cost;Data Reporting;Depressed mood;design;Dose;drug candidate;drug development;Drug Kinetics;efficacy clinical trial;experience;exposed human population;Feedback;Female;first-in-human;Formulation;Funding;Grant;heart rate monitor;Human;Letters;Lifting;male;meetings;Methods;mortality;new chemical entity;Nicotinic Receptors;novel;novel therapeutics;Oral;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;Phase I Clinical Trials;phase I trial;phase II trial;Plasma;preclinical study;preservation;Procedures;Published Comment;Randomized;Rattus;Recommendation;Regimen;response;safety assessment;small molecule;smoking abstinence;smoking cessation;Telemetry;Testing;Toxic effect;Toxicokinetics;Writing

PROJECT_TITLE: First-in-Human Clinical Development of a Novel Drug Candidate with a First-in-Class Mechanism for Smoking Cessation and Abstinence


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Substance Misuse

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative The proposed R01 application builds upon the extensive work from our laboratory on the development of a maximally translational task for drinking motivation in humans. This study will test the three dimensions of the Addiction Neuroclinical Assessment (ANA) for their respective effects on motivation for alcohol in individuals with alcohol use disorder.

PI_NAMEs: RAY, LARA A. (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: 3-Dimensional;addiction;alcohol craving;alcohol reinforcement;alcohol reward;alcohol seeking behavior;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;analytical method;Attention;Basic Science;Behavior;Behavioral Sciences;Biological Markers;biomarker development;Blood specimen;Blood Tests;blood-based biomarker;breath alcohol measurement;Clinical;clinical application;Clinical Sciences;clinical translation;Collection;Computer Assisted;Corticotropin;craving;Data Analytics;Data Set;Development;Dimensions;discounting;disease classification;Disease Progression;drinking;Emotional;Ethanol;Executive Dysfunction;Growth;Human;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Impairment;incentive salience;Individual;Inflammation;Infusion procedures;innovation;insight;Interleukin-10;Interleukin-6;intravenous administration;Laboratories;Longterm Follow-up;Machine Learning;machine learning model;Methodology;Modeling;Motivation;negative mood;Neurobiology;Outcome;Outcome Assessment;Participant;Patient Self-Report;Peripheral;phenomenological models;Phenotype;pre-clinical;pre-clinical research;preference;Protocols documentation;Reporting;Research;response;Rewards;Role;Sampling;Schedule;Self Administration;Severities;Side;Staging;System;Testing;therapy development;TNF gene;Translational Research;Translations;Work

PROJECT_TITLE: Translational underpinnings of motivation for alcohol in humans

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Infectious Diseases;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: UNIVERSIDAD PERUANA CAYETANO HEREDIA

PHR: Oxfendazole in Fascioliasis Principal Investigators/Program Directors: GARCIA, Hector H./ CABADA, Miguel M. A Non-Inferiority Randomized Single Blind Controlled Trial Comparing One and  Two Dose Regimes of Oxfendazole versus a Two Dose Regime of  Triclabendazole to Treat Chronic Fascioliasis PROJECT NARRATIVE  Fasciola hepatica infection causes liver disease in endemic regions, affecting between 2.6 and 17 million people around the world. Treatment is suboptimal. Triclabendazole, the only highly effective drug, is not widely available, and there is concern for the spread of resistant infections in humans. Oxfendazole is a veterinary benzimidazole with a wide anti-helminthic spectrum, highly effective against Fasciola, but it has not yet been evaluated in humans. We have completed animal toxicology and phase I studies of oxfendazole in humans, confirming its high bioavailability and, importantly, safety. We will compare two oral oxfendazole regimens, a single 20 mg/kg dose and two 20 mg/kg doses, against the standard of care of two 10 mg/kg oral doses of triclabendazole for the treatment of human fascioliasis. This study will be the first efficacy evaluation of oxfendazole in a tissue parasite of humans, and a significant step forward towards making this promising drug available for treatment of human parasitic infections. This resubmission address the reviewer’s comments and presents a comprehensive discussion of the study procedures.

PI_NAMEs: CABADA, MIGUEL MAURICIO;GARCIA, HECTOR HUGO (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Adult;Affect;Animals;Anthelmintics;Antiparasitic Agents;Area;arm;benzimidazole;Biological Availability;Case Study;Child;Chile;Chronic;climate change;Clinical Trials;Communities;comparative efficacy;Conduct Clinical Trials;Controlled Clinical Trials;Country;Cysticercosis;Data;design;Developing Countries;Development;Dose;drug development;Drug Exposure;Drug Kinetics;effective therapy;efficacy evaluation;Enrollment;Ensure;Environment;Epidemiology;Evaluation;experience;Exposure to;farmer;Fasciola;Fasciola hepatica;Fascioliasis;Formulation;helminth infection;Helminths;Human;human tissue;Infection;Literature;Liver diseases;Livestock;Logistics;Measures;Meleagris gallopavo;Methods;Modeling;multidisciplinary;Nature;Netherlands;novel therapeutics;Oral;Parasites;Parasitic infection;Parasitology;Persons;Peru;Pharmaceutical Preparations;pharmacokinetic model;Phase;phase 1 study;Population;Portugal;Principal Investigator;Procedures;programs;Published Comment;Randomized;randomized, clinical trials;Regimen;Reporting;Research;Research Personnel;Resistance;Safety;Sheep;Single-Blind Study;Solid;standard of care;Taenia solium;Tissues;Toxicology;Treatment Protocols;trial comparing;Variant;Work;Zoonoses


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: MILWAUKEE

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: Project Narrative Sexual assault among college students who identify as a sexual minority is a significant public health problem. The current study will be the first to examine, among sexual minority college students, (1) whether alcohol use temporally increases the risk of sexual assault perpetration and victimization, (2) whether sexual assault victimization temporally increases the risk for alcohol use, (3) whether sexual minority stress risk and protective factors moderate of the temporal associations between alcohol and sexual assault, and (4) whether findings vary for sexual minority students with other intersecting, marginalized identities (i.e., gender minority; ethnic minority). The information obtained from this study will have direct relevance for researchers and clinicians who are interested in the reduction of alcohol-related sexual assault among LGB+ college students.

PI_NAMEs: SHOREY, RYAN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: adverse outcome;Affect;Alcohol consumption;alcohol effect;alcohol myopia;alcohol risk;Alcohols;Anus;assault;Attention;Awareness;Belief;binge drinking;Buffers;Cognitive;college;Communities;Complex;coping;Cues;Data;Development;diaries;Discrimination;Distal;drinking;Emotional;ethnic minority;Ethnic Origin;experience;follow-up;Future;Gender Identity;gender minority;health disparity;heavy drinking college student;Heterosexuals;Homophobia;Individual;Inequality;innovation;insight;interest;intersectionality;Intervention;intervention program;Intervention Studies;Interview;Intoxication;Lesbian Gay Bisexual;Link;Literature;Lived experience;marginalization;Methodological Studies;Methods;Minority;minority stress;minority student;Modeling;non-heterosexual;Oral;Outcome;Participant;peer;Penetration;perpetrators;Persons;Population;Prevention;Prevention program;protective factors;Psychopathology;Public Health;Publishing;Reporting;Research;Research Personnel;Risk;Risk Factors;Self Medication;sex;Sex Orientation;Sexual Arousal;sexual assault;sexual minority;sexual minority stress;social;Social Identification;Social support;Stress;Students;Surveys;Theoretical model;theories;Touch sensation;Translating;Trauma;university student;Vagina;verbal;Victimization

PROJECT_TITLE: The Impact of Minority Stress on Alcohol-Related Sexual Assault among Sexual Minority College Students: An Intersectional, Mixed-Methodological Study

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Depression;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: ROCHESTER

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Advancements in computational psychiatry allow us to isolate the contributions of multiple, specific, cognitive mechanisms that contribute to the behavior that we see in everyday life. This approach fills a critical unmet need in psychiatry by generating mathematically precise variables that can bridge the gap between pathophysiology and psychopathology. The main goals of the current project are to: 1) test the idea that computational metrics have enhanced validity and sensitivity relative to standard behavioral performance metrics in key psychiatric and nonpsychiatric populations and to relate these metrics to EEG markers of brain function; and 2) establish and optimize the psychometrics of these computational metrics so that they can be used as tools in treatment development, longitudinal studies, and genetic studies. !

PI_NAMEs: SILVERSTEIN, STEVEN M (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;Affective;Anhedonia;Assessment tool;Attention;Behavior;behavior measurement;Behavioral;Big Data;Brain;Clinic;Clinical;clinical application;clinical predictors;Cognition;Cognitive;cognitive function;cognitive neuroscience;cognitive process;cognitive system;cognitive testing;Communities;computerized tools;Data;Data Collection;Decision Making;Dimensions;discounting;Electroencephalography;Episodic memory;Evaluation Studies;flexibility;Floor;Functional disorder;functional outcomes;Genetic;Genetic study;Goals;Gold;Human;Impaired cognition;Impairment;Individual;interest;Internet;Intervention;Laboratories;Learning;Life;Longitudinal Studies;Mathematics;Measurement;Measures;Mental Depression;Mental disorders;Methods;Modeling;Mood Disorders;Motivation;neural;neuromechanism;neurophysiology;novel;Parameter Estimation;Patient Recruitments;Patients;Pattern;Perception;Performance;Population;population based;Positive Valence;precision medicine;Productivity;Property;Psychiatry;psychologic;Psychological reinforcement;Psychometrics;Psychopathology;Psychotic Disorders;psychotic-like experiences;recruit;Research;Research Domain Criteria;Research Personnel;Resources;Sampling;severe mental illness;Short-Term Memory;Site;spatiotemporal;Specific qualifier value;Specificity;Symptoms;System;Task Performances;Testing;therapy development;tool;tool development;Translating;Variant;Visual Perception;web-based tool;Work

PROJECT_TITLE: Cognitive Neurocomputational Task Reliability & Clinical Applications Consortium


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: By 2030 an estimated 2 million people in the US will need dialysis or transplantation. There are an estimated 45,500 veterans receiving hemodialysis, of which over 3,000 enrolled veterans were receiving HD at VA facilities in FY 2013. Due to the increasing number of patients with diabetes and obesity, it is likely that this cohort will expand in the future, which renders this project highly relevant to the VA population. Insulin resistance and chronic inflammation are common in dialysis patients and have been linked to protein-energy wasting, the most important determinant of clinical outcome in this patient population. We hypothesize that the skin and muscle tissue sodium accumulation is a critical mechanism by which chronic inflammatory response and insulin resistance, alone or in combination lead to protein energy wasting in hemodialysis patients. We will test this hypothesis by studying dialysis patients and matched controls without kidney disease by examining tissue Na content, markers of inflammation and protein metabolism.

PI_NAMEs: IKIZLER, TALAT ALP (contact)

PROJECT_TERMS: Acceleration;Age;Amino Acids;Body mass index;Catabolism;Chronic;Clinical;clinical practice;cohort;Data;Death Rate;Development;Diabetes Mellitus;Dialysis patients;Dialysis procedure;Diet;End stage renal failure;Enrollment;Equilibrium;Excision;Frequencies;Future;Gender;Glucose;Goals;Healthcare;Hemodialysis;hospitalization rates;Hour;Immune;immune activation;Immune system;improved;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;innovation;Insulin;Insulin Resistance;insulin sensitivity;Intake;Intervention;Kidney Diseases;Lead;Link;Macronutrients Nutrition;Magnetic Resonance Imaging;Maintenance;Metabolic;Mission;Morbidity - disease rate;mortality;Muscle;nutrition;Nutritional;Obesity;Outcome;Pathogenesis;Pathway interactions;patient population;Patients;Peripheral;Persons;pharmacologic;Pilot Projects;Play;Population;prevent;primary outcome;Progress Reports;protein metabolism;Proteins;Protocols documentation;Race;randomized, clinical trials;Reporting;Research;Resistance;response;Risk;Role;Skeletal Muscle;Skin;Skin Tissue;Sodium;systemic inflammatory response;Testing;Tissues;Transplantation;United States;United States Department of Veterans Affairs;Veterans;wasting;Water

PROJECT_TITLE: Nutrition, Inflammation and Insulin Resistance in End-Stage Renal Disease


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE In addition to the obvious anatomical differences, males and females differ in more subtle ways that are also important but are poorly understood and cannot be explained by hormones alone. We use fruit flies (Drosophila melanogaster) as an experimental model to study the molecular basis of sex differences in metabolism, focusing on differences within fat storage cells. The fly genes we study have human counterparts that may influence human susceptibility to obesity and other metabolic disorders.

PI_NAMEs: DIAZ, ARELY VIRIDIANA (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Adipose tissue;Affect;Anatomy;Animals;Behavioral;Binding;Body fat;Catabolism;Cells;Chromosomal Duplication;Clone Cells;Complex;Cultured Cells;Dependence;dimorphism;Drosophila genus;Drosophila melanogaster;Enzymes;Experimental Models;experimental study;Family;Fat Body;Fatty acid glycerol esters;Female;Feminization;fly;Gene Expression;gene function;Genes;Genetic;glucose uptake;Goals;Gonadal Steroid Hormones;Gonadal structure;Hormones;Human;Individual;insight;knock-down;Larva;lipid metabolism;Lipids;Liver;male;Mammals;member;Messenger RNA;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Methylation;Methyltransferase;Modification;Molecular;Monitor;Neurologic;Obesity;Organ;Ovary;overexpression;Pathway interactions;Phenocopy;Predisposition;preservation;Protein Isoforms;recruit;Regulation;Regulator Genes;Research;RNA;RNA Splicing;RNA-Binding Proteins;Role;sex;Sex Chromosomes;sex determination;Sex Differences;sexual dimorphism;Signal Transduction;System;Testing;Thinness;Tissues;tool;Transcript;transcriptomics;Translations;Wing;women versus men;Work

PROJECT_TITLE: The role of Spenito and m6A in establishing sexually dimorphic metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)B]


ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: NARRATIVE The overall vision of the “Kaposi Sarcoma in the Era of ART in Africa Program (KEAAP)” is to build a collaborative network between the Cancer Diseases Hospital and the University Teaching Hospitals in Zambia, the Ocean Road Cancer Institute in Tanzania, and the Stanley S Scott Cancer Center at the Louisiana State University Health Sciences Center-New Orleans, to conduct cutting edge research that will lead to a better understanding of Kaposi sarcoma, a common HIV associated cancer in Africa. KEAAP is high impact because it builds on successful ongoing Fogarty and NCI training programs, it will implement a cross-disciplinary tri- lateral research and training program driven by our Tanzanian and Zambian collaborators with broad local support to ensure their sustainability. The lessons learned will also benefit Louisiana HIV-1 and cancer research since the state has the fifth largest population of people living with HIV, mostly among its health disparities population.

PI_NAMEs: MWAISELAGE, JULIUS DAVID;NGALAMIKA, OWEN ;WOOD, CHARLES  (contact)

PROGRAM_OFFICER_NAME: KALEEBA, JOHNAN AUGUSTINE

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;AIDS related cancer;anti-cancer research;antiretroviral therapy;Bilateral;Cancer Biology;Cancer Center;Cancer Patient;Cancer Research Infrastructure;Caring;Chronic;clinical care;Collaborations;Core Facility;Country;Detection;Diagnosis;Disease;Educational workshop;Ensure;Epidemic;Etiology;Fostering;Funding;Future;Goals;health disparity populations;Health Sciences;HIV;HIV-1;HIV/AIDS;Hospitals;Human Herpesvirus 8;Human Resources;immune activation;Immune response;Immunosuppression;Incidence;Individual;Kaposi Sarcoma;Lateral;Lead;Leadership;Link;Louisiana;low and middle-income countries;Malignant Neoplasms;Mediating;Mentors;metabolome;Molecular;next generation;Oceans;Oncology;Outcome;Pathogenesis;Pathology;Patients;Persons;Pilot Projects;Population;Positioning Attribute;prevent;programs;Public Health;Research;Research Infrastructure;Research Personnel;Research Project Grants;Residual state;Staging;success;Tanzania;Teaching Hospitals;Technology Transfer;Tissues;Training;Training Activity;Training and Infrastructure;Training Programs;United States;Universities;Viral;Vision;Zambia