NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: The focus of this project is on deciphering the molecular mechanisms of compensatory hepatocyte proliferation in liver regeneration following hepatic damages. Our preliminary data have suggested a new function of CD133, a well-known biomarker in stem cells and cancer stem cells, in mediating intercellular communication to compensate deficit in intracellular proliferative signaling. Success of this project will elucidate a previously unappreciated inherent function of normal and cancer cells, which may be implicated in drug resistance of cancer.

PI_NAMEs: FENG, GEN-SHENG  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Activities of Daily Living;Address;AFP gene;anti-cancer research;antiproliferative drugs;Autophagocytosis;Biological Markers;Biological Process;Blood;cancer biomarkers;cancer cell;cancer drug resistance;cancer stem cell;Cell Proliferation;cell type;Cells;Communication;Compensation;cytokine;Data;DDR1 gene;Defect;Dissection;Drug resistance;EGF gene;Epidermal Growth Factor Receptor;Excision;experimental study;Goals;Growth Factor;Growth Factor Receptors;Hepatic Mass;Hepatocyte;Human;Impairment;In Vitro;in vivo;in vivo Model;intercellular communication;Interleukin-6;Knock-out;Lead;Literature;Liver;liver cell proliferation;liver injury;Liver neoplasms;Liver Regeneration;Living Donors;Mammals;Mediating;Molecular;multidisciplinary;Mus;Mutant Strains Mice;Normal Cell;Nutritional;Operative Surgical Procedures;Partial Hepatectomy;Pattern;Process;Proliferating;Protein Tyrosine Phosphatase;Rattus;receptor;Receptor Protein-Tyrosine Kinases;regenerative;resistance mechanism;Resolution;response;restoration;Role;Signal Pathway;Signal Transduction;Signaling Molecule;stem cell biology;stem cell biomarkers;stem cells;stemness;Stress;Structure;success;TACSTD1 gene;Testing;transcriptome sequencing;Transplantation;tumor;Vesicle

PROJECT_TITLE: A new mechanism of hepatocyte proliferation under stress

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Palliative Care;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: TAMPA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Slowing muscle loss and increasing strength and physical function may be important to increasing health- related quality of life among individuals undergoing chemotherapy for advanced upper gastrointestinal cancers. We aim to test the feasibility, safety, and acceptability of a home-based, “tele-resistance training” program in which patients will engage in exercise sessions via video conferences with certified trainers. We will compare changes in fitness, muscle health, health-related quality of life, fatigue, and physical functioning between patients participating in tele-RT and patients who have no exercise program to better understand the value of exercise in this context.

PI_NAMEs: PARKER, NATHAN H (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Acceleration;Accountability;Adherence;Advanced Malignant Neoplasm;Aerobic Exercise;Age;barrier to care;Cancer Center;Cancer Survivor;Cancer Survivorship;cancer therapy;Certification;Cessation of life;chemotherapy;Clinical;cohort;Communicable Diseases;Computer software;Coupled;Data;density;design;Disease;Dissemination and Implementation;Early treatment;Educational Intervention;Effectiveness;Enrollment;Esophagus;Exercise;exercise adherence;exercise intervention;exercise prescription;exercise program;Face;Familiarity;Family;Fatigue;Feasibility Studies;feasibility testing;fitness;Foundations;functional independence;Future;Geographic Locations;Glean;Habilitation;Health;health related quality of life;Home;Impairment;implementation research;improved;indexing;Individual;innovation;Intervention;Interview;Liver;Maintenance;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Monitor;Muscle;Muscle Development;Muscular Atrophy;novel strategies;Oncology;Outcome;Outcome Measure;palliative chemotherapy;Pancreas;pandemic disease;Participant;Patient Outcomes Assessments;Patient Participation;Patients;Performance Status;Personal Satisfaction;Persons;Physical Function;Physiological;Pilot Projects;Population;preference;Prevention;Prognosis;programs;Quality of life;Questionnaires;Randomized;Recommendation;Regimen;Research;Research Personnel;Research Priority;Resistance;resistance exercise;Safety;sarcopenia;Skeletal Muscle;skeletal muscle wasting;skills;Social support;Specialist;Stomach;Supervision;Supportive care;Survival Rate;Survivors;survivorship;symposium;Tablet Computer;Testing;therapy development;Time;Training;Training Programs;Translating;treatment as usual;Treatment outcome;Tube;Upper digestive tract structure;upper gastrointestinal cancer;Videoconferencing;virtual;Work

PROJECT_TITLE: Tele-resistance training during chemotherapy for advanced upper gastrointestinal cancer


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE Stochastic fluctuations in gene expression impact cell-fate specification decisions from embryogenesis to viral infection creating barriers for effective treatment interventions. Based on therapeutic precedents in neuroscience that use fluctuations to improve sensorimotor function, this project will identify centralized molecular and cellular mechanisms of noise modulation, that can be therapeutically targeted, in embryonic stem cells (ESCs). The proposed research will lead to development of new broad-spectrum noise modulators, and propel clinical translation of noise-modulating molecules to guide new therapeutic approaches that overcome barriers to precise cell-fate control in diverse mammalian systems.

PI_NAMEs: WEINBERGER, LEOR S (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Address;Affect;Architecture;Attenuated;Award;Bacteria;biological systems;Cell Fate Control;cell fate specification;Cells;Cellular biology;Chemosensitization;circadian;Circadian Rhythms;Clinical;clinical translation;Cytoplasm;Data;Development;Disparate;drug repurposing;effective therapy;Electrophysiology (science);Embryonic Development;embryonic stem cell;Engineering;Enhancers;Evolution;FDA approved;Feedback;Flow Cytometry;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Heterogeneity;HIV;improved;in vivo;Intervention;knock-down;Knowledge;Literature;Malignant Neoplasms;Mammalian Cell;Maps;mathematical model;Modeling;Molecular;molecular modeling;mutant;Neurosciences;Noise;novel;novel therapeutic intervention;Nuclear Export;Outcome;Pathway interactions;pharmacologic;posttranscriptional;predictive modeling;reactivation from latency;Reporter;Research;Rest;Role;Safety;Science;Sensorimotor functions;Source;Specific qualifier value;Starvation;stem cells;Stress;synergism;System;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Therapeutic Effect;therapeutic target;tool;Transcription Coactivator;transcriptome;Translations;Viral;Virus Diseases;Virus Latency;Work;Yeasts

PROJECT_TITLE: Modulating Stochastic Gene Expression for Cell-fate Control and Therapeutics

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Suicide;Suicide Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: ADRIAN, MOLLY  (contact)

PROJECT_TERMS: Acceleration;Acute;Address;Adolescent and Young Adult;Adoption;Age;barrier to care;Behavior;behavioral health;care providers;Caregivers;Caring;Cause of Death;Characteristics;Communication;Complex;Data;Decision Making;design;Development;Distress;Effectiveness;Engineering;Evaluation;evidence base;Evidence based intervention;expectation;Experimental Designs;Family;Feeling suicidal;Health Personnel;Healthcare;Healthcare Systems;Hospitalization;human centered design;Hybrids;implementation outcomes;implementation trial;improved;Individual;Intervention;Mediation;Medical;Mental Health Services;Modeling;modifiable risk;mortality;multi-component intervention;multiphase optimization strategy;novel;Outpatients;Parents;Pathway interactions;Patients;Pattern;prevent;Prevention;primary care setting;Process;Proliferating;Provider;Public Health;Recording of previous events;reducing suicide;referral services;Reporting;Research;response;Risk Factors;Risk Management;Risk Reduction;Self Efficacy;skills;skills training;suicidal;suicidal adolescent;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;Testing;Therapeutic;Time;treatment optimization;treatment planning;United States;usability;Youth

PROJECT_TITLE: Swift Outpatient Alternatives for Rapid Stabilization (SOARS)


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Parkinson's Disease;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Many genetic risk factors have been found for the various neurodegenerative diseases, but few of them have been functionally characterized in a way that is likely to lead to therapies for the millions of people who suffer from Alzheimer’s Disease, Parkinson’s Disease, Frontotemporal Dementia, and Amyotrophic Lateral Sclerosis. We seek here to understand how one genetic risk factor, TMEM106B, confers risk for neuronal loss, through lysosomal pathways that may affect a spectrum of neurodegenerative diseases.

PI_NAMEs: CHEN-PLOTKIN, ALICE S (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Affect;Age;ALS patients;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyotrophic Lateral Sclerosis;Architecture;Area;Autophagocytosis;Autophagosome;Autopsy;Biological;Biological Process;Biology;C9ORF72;CCCTC-binding factor;Cells;Cessation of life;Chromatin;cohort;Collaborations;Coupled;Data;Defect;Dementia;Development;Diagnosis;Disease;Disease Progression;disorder risk;endophenotype;Enzymes;experimental study;follow-up;Frontotemporal Dementia;Genes;Genetic;Genetic Risk;genetic risk factor;genetic variant;genome wide association study;genomic locus;Genotype;Health;Human;human disease;Human Genetics;insight;Institution;Investigation;Ions;knock-down;Knowledge;loss of function mutation;lysosomal proteins;Lysosomes;Measurement;Membrane;Molecular;Mutation;mutation carrier;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;neuropathology;new therapeutic target;novel;Organelles;Parkinson Disease;Pathway interactions;Patients;Persons;Phenotype;prevent;Progress Reports;protein protein interaction;Quantitative Trait Loci;recruit;Reporting;Risk;Risk Factors;risk variant;Role;Single Nucleotide Polymorphism;Sorting;syntaxin;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapy development;Translating;vacuolar H+-ATPase;Variant;Work

PROJECT_TITLE: TMEM106B in neurodegenerative disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Nutrition;Palliative Care;Racial and Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Although current clinical evidence suggests that the potential benefits of tube feeding do not exceed considerable associated treatment burdens in older adults with advanced dementia, rates of tube feeding remain disproportionally high among Chinese-American older adults with advanced dementia. This proposed project will culturally adapt an existing decision aid intervention to improve decision-making about feeding options for Chinese-American dementia patients. If effective, this intervention will indicate the utility of decision aids as a methodology with broader applications to decision-making in end-of-life care in this population.

PI_NAMEs: PEI, YAOLIN  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: acceptability and feasibility;Address;advanced dementia;advanced directive;Aging;Alzheimer's disease related dementia;American;Area;Asia;Award;Behavior Therapy;Behavioral Research;Benefits and Risks;Caregivers;Caring;Characteristics;Chinese;Chinese American;Chinese population;Cities;Clinical;Clinical Trials Design;cognitive interview;Communities;community collaboration;community organizations;comparison group;Conflict (Psychology);Cultural Sensitivity;cultural values;Data;Decision Aid;Decision Making;Dementia;Dementia caregivers;Development;Disadvantaged;Eating;Education;Educational Materials;efficacy evaluation;efficacy testing;end of life;end of life care;end-of-life decision making;Ensure;Enteral Feeding;Environment;Equilibrium;Ethnic Origin;evidence base;Family;Family Caregiver;Family health status;Family member;family structure;feeding;Food;Fostering;Geriatrics;Goals;Grant;Hand;Health Benefit;Health Personnel;Health Professional;Heart;heuristics;High Prevalence;Hybrids;improved;Individual;Intervention;Intervention Studies;Interview;Knowledge;Language;Leadership;Linguistics;Literature;Mentors;Methodology;Mission;New York;New York City;Nurses;nutrition;Nutritional status;older adult;Outcome;Participant;Pathway interactions;Patient Preferences;Patients;Persons;Phase;Physicians;pilot test;Population;preference;Process;Professional Organizations;prototype;Qualitative Methods;Randomized, Controlled Trials;Reading;Recommendation;Research;research and development;Research Methodology;Research Personnel;research study;Research Support;Resources;Risk;Scientist;shared decision making;Signal Transduction;skills;Social Workers;Societies;Speech Therapist;success;support tools;surrogate decision making;Testing;therapy development;tool;Training;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: A culturally adapted decision aid intervention to support Chinese American dementia caregivers in feeding-related decisions

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dietary Supplements;Infant Mortality;Infectious Diseases;Nutrition;Pediatric

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: Project Narrative Bacterial infections among young infants, including sepsis, meningitis, pneumonia, and others, continue to have a substantial burden in developing countries and are estimated to cause ~33% of neonatal deaths. The proposed randomized, double-blind, placebo-controlled trial will examine whether zinc supplementation combined with standard antibiotic treatment improves survival and treatment outcomes for Tanzanian young infants 0-59 days with clinical severe infection.

PI_NAMEs: DUGGAN, CHRISTOPHER P;SUDFELD, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Africa South of the Sahara;Age;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Asia;Bacterial Infections;Biological;Case Fatality Rates;Cessation of life;Chest;Child;Child Mortality;Childhood;Clinical;Clinical Management;cost;Data;Developing Countries;Development;disability;double-blind placebo controlled trial;efficacy testing;Enrollment;Etiology;Exposure to;Genetic;Goals;Growth;Guidelines;Health;Heterogeneity;hospital readmission;Hospitalization;Hospitals;improved;Incidence;Infant;Infant Health;Infant Mortality;Infection;innovation;Innovative Therapy;Intervention;Length;Life;low and middle-income countries;Magnesium;Meningitis;Meta-Analysis;Modification;Morbidity - disease rate;mortality;Movement;Neonatal Mortality;neonate;Northern Africa;Nutrient availability;Nutritional status;Oral;Outcome;Participant;Placebos;Pneumonia;Policies;Population;primary outcome;Probability;Publishing;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Regimen;Reporting;Risk;Sample Size;secondary outcome;Sepsis;Severities;Signs and Symptoms;Specimen;success;survival outcome;Sustainable Development;Tablets;Tanzania;Temperature;Time;treatment effect;Treatment Failure;Treatment outcome;Variant;Vital Status;Weight;World Health Organization;Zinc deficiency;Zinc Sulfate;Zinc supplementation

PROJECT_TITLE: Trial of Zinc Supplements for Young Infants with Clinical Severe Infection in Tanzania

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Biological membranes are self-assembled molecular walls that are found within and around the cells of all living organisms. Rather than serving simply as barriers to establish boundaries however, these essential dynamic structures provide a unique environment for organizing steps in biological pathways. This work will elucidate whether proteins in membrane- associated pathways that elaborate sugar structures perform their function, as isolated entities or as collaborative teams. Ultimately this work will provide insight into fundamental biological processes including bacterial infection.

PI_NAMEs: ALLEN, KAREN N.;IMPERIALI, BARBARA  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Active Sites;Adopted;Algorithms;amphiphilicity;Anabolism;Asparagine;Bacteria;Bacterial Infections;Binding;Biochemical;Biological;Biological Assay;Biological Process;Biophysics;Campylobacter;Cells;Complex;Computer Analysis;Data;Development;Diffusion;Dimensions;Diphosphates;Disease;Docking;Dolichol;Elements;Environment;Enzyme Interaction;Enzyme Kinetics;enzyme pathway;Enzymes;Epsilonproteobacteria;feature selection;Frequencies;frontier;Future;Genome;Genomics;Glucose;Glycoconjugates;Glycoproteins;glycosylation;glycosyltransferase;Goals;Health;Human;in vivo;Individual;insight;Kinetics;Knowledge;Label;Life;Ligand Binding;Link;link protein;Logic;maleic acid;Membrane;membrane model;Membrane Proteins;Metabolism;Methods;Modeling;models and simulation;Molecular;molecular assembly/self assembly;molecular dynamics;Multienzyme Complexes;Nature;Neighborhoods;novel;Operon;Organism;Orthologous Gene;Output;Pathway interactions;Peptidoglycan;Phase;Phospholipids;Play;Plumbing;Polysaccharides;Process;Property;Protein Analysis;Protein Glycosylation;protein protein interaction;Proteins;Proteobacteria;Radioactivity;Reaction;recruit;Research;Roentgen Rays;Role;Series;simulation;Site;Site-Directed Mutagenesis;Specificity;Structure;Styrenes;Substrate Interaction;sugar;System;Teichoic Acids;Testing;undecaprenyl pyrophosphate;Uridine Diphosphate Sugars;Variant;Virulence;Work;X-Ray Crystallography

PROJECT_TITLE: Deciphering the Principles of Membrane-Associated Glycan Assembly for Glycoconjugate Biosynthesis

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Patient Safety;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research

PI_NAMEs: BENNETT, IAN MOORE (contact)

PROJECT_TERMS: acceptability and feasibility;Address;age group;aged;Agreement;Ambulatory Care Facilities;Back;Behavior;care delivery;Caring;Cause of Death;Characteristics;Clinic;Clinical;clinical care;clinically actionable;clinically relevant;coping;Critical Pathways;Data Collection;design;Detection;Development;Devices;digital;Ecological momentary assessment;Enrollment;ethnic diversity;Evaluation;evidence base;Feeling suicidal;Future;Goals;health care settings;Health Personnel;high risk;human centered design;implementation evaluation;improved;Individual;innovation;Intervention;Low income;Medical;medical delivery system;Mental Depression;Methodology;Methods;Monitor;mortality;Outcome;Outpatients;Pathway interactions;Patient-Focused Outcomes;patient-level barriers;Patients;Perinatal mortality demographics;Pilot Projects;point of care;Population;Population Heterogeneity;Populations at Risk;preventable death;primary care clinician;primary care services;primary care setting;Primary Health Care;Process;prospective;prototype;Provider;racial diversity;Recurrence;Reporting;Research;Resources;response;Risk;risk prediction;screening;Self Efficacy;shared decision making;Signal Transduction;Site;Sleep Disorders;social media;Source;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;Symptoms;System;Technology;Therapeutic;tool;Training;United States;usability;Visit;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Social Media Signals for reducing Perinatal Death by Suicide


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Radiation Oncology

ORG_CITY: MADISON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The University of Wisconsin Comprehensive Cancer Center (UWCCC), in collaboration with the National Clinical Trials Network (NCTN), seeks to bring innovative cancer treatment trials to the population of Wisconsin and its neighboring regions to reduce the burden of cancer. Through leadership in the NCTN Cooperative group program, the UWCCC faculty are working to design the next generation of genomically-directed clinical trials, as well as those that utilize advanced imaging techniques.

PI_NAMEs: BARROILHET, LISA M;BASCHNAGEL, ANDREW MICHAEL;WILKE, LEE GRAVATT;WISINSKI, KARI BRAUN (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: American College of Radiology Imaging Network;American College of Surgeons Oncology Group;Cancer Burden;Cancer Center;cancer clinical trial;cancer education;Cancer Patient;cancer therapy;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Cooperative Group Program;Data;data management;design;Development;Eastern Cooperative Oncology Group;Ensure;experience;Faculty;Genomics;Goals;Grant;Gynecologic Oncology;Gynecologic Oncology Group;Image;Imaging Techniques;Infrastructure;innovation;Institution;interdisciplinary approach;interest;Leadership;Malignant Neoplasms;Medical Oncology;Mission;Modernization;multidisciplinary;National Clinical Trials Network;NCI Center for Cancer Research;next generation;novel;Oncology;Phase;Phase II/III Clinical Trial;Population;Population Heterogeneity;Prevention;Principal Investigator;programs;Protocols documentation;Radiation Oncology;Radiation Therapy Oncology Group;Research;Research Infrastructure;Research Personnel;Resources;Strategic Planning;Structure;Surgical Oncology;Therapeutic;Translational Research;treatment trial;Underserved Population;Universities;University of Wisconsin Comprehensive Cancer Center;Wisconsin

PROJECT_TITLE: National Clinical Trials Network Research at the University of Wisconsin


NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE  The supply-to-demand ratio of tRNAs relative to the codon usage in a cell determines the fitness of the cell. While most studies show that the supply in the form of tRNA abundance correlates with the codon usage, little is known about the supply in the form of tRNA post-transcriptional modifications. We will use E. coli as a starting point to elucidate the principles of how the status of tRNA post-transcriptional modifications influences the translation of a specific codon usage pattern to the proteome, test the predictive power of the principles in the human proteome, and evaluate the principles in a mitochondrial disease.

PI_NAMEs: HOU, YA-MING  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TITLE: tRNA in codon usage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Natural Products;Neurosciences;Pediatric;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE While personal cannabis use and secondhand cannabis smoke exposure is prevalent among youth, the influence of these on adolescent cognitive development remains understudied. Cannabis product complexity and limitations of self-report may obscure important relationships between delta-9-tetrahydrocannabinol (THC) and neurocognitive development/outcomes. Here we propose using quantifiable toxicological information of personal and secondhand cannabis exposure from hair to predict cognitive functioning over time in adolescents.

PI_NAMEs: WADE, NATASHA E (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Abstinence;Acute;Adolescence;Adolescent;adolescent substance use;Adult;Age;Age Years;Agonist;Attention;Award;Behavior;behavior influence;behavior measurement;Binding;Biological Availability;Brain;Cannabinoids;Cannabis;career;Categories;Chemical Exposure;Chemicals;Child;Classification;Clinical;CNR1 gene;Cognition;Cognitive;cognitive development;cognitive function;cognitive performance;cognitive task;cohort;Complement;Consumption;critical period;Data;Development;Dose;Drops;Drug Kinetics;early adolescence;Eating;emerging adult;endogenous cannabinoid system;Ensure;Environment;Environmental Exposure;environmental tobacco smoke;environmental tobacco smoke exposure;Exhibits;experience;Exposure to;Flowers;follow-up;Frequencies;Funding;Genetic;Goals;Hair;Household;Human;improved;Individual;Intoxication;Investigation;Knowledge;Learning;Legal Status;Length;Link;Literature;Male Adolescents;marijuana use;marijuana user;Mass Spectrum Analysis;Measurable;Measurement;Measures;Memory;Mentorship;Methodology;Methods;Modeling;Monitor;National Institute of Drug Abuse;Neurocognition;Neurocognitive;neurodevelopment;novel;open data;Outcome;Parents;Participant;Patient Self-Report;Pattern;Performance;Pharmaceutical Preparations;Plants;Policies;Population;Predisposition;Protocols documentation;Receptor Signaling;Reporting;Research;Research Personnel;risk perception;Sampling;Scientist;secondhand cannabis smoke;Short-Term Memory;Smoke;statistics;substance use;Tetrahydrocannabinol;THC concentration;THC exposure;Time;tool;Toxicology;Training;Urinalysis;Variant;verbal;Work;young adult;Youth

PROJECT_TITLE: Cannabis Toxicology in Relation to Neurocognitive Outcomes in Adolescents

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research

PI_NAMEs: COMTOIS, KATHERINE ANNE (contact)

PROJECT_TERMS: acceptability and feasibility;addiction;Adolescent and Young Adult;Adoption;behavioral health;Bipolar Disorder;Caring;Clinical;Cognitive Therapy;collaborative care;coping;Coping Skills;cost effectiveness;Crisis Intervention;demographics;design;Diabetes Mellitus;Dialectical behavior therapy;Emotions;evidence base;Family;Family member;Feeling;Feeling hopeless;Feeling suicidal;follow-up;Health Personnel;Hearing;Heart Diseases;human centered design;improved;improved outcome;Inpatients;integrated care;Intervention;intervention program;Malignant Neoplasms;medical specialties;Medication Management;member;Mental Health Services;Methods;Modeling;mortality;Needs Assessment;Outcome;Pathway interactions;Patients;pilot test;Prevention Research;Primary Care;primary care clinic;primary care setting;Provider;Psychiatry;psychologic;Psychotherapy;Recording of previous events;reducing suicide;Research;response;Risk Assessment;Risk Factors;Risk Management;screening;Self Efficacy;Self-Injurious Behavior;Series;social;suicidal;suicidal adolescent;suicidal individual;suicidal patient;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Support System;Switzerland;symposium;Testing;Therapeutic;therapy development;therapy outcome;treatment as usual;Universities;usability;Videotape;Washington

PROJECT_TITLE: Aeschi Model in Integrated Care: Treatment Development Study to Improve Outcomes for Suicidal Patients


ADMINISTERING_IC: AA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Alcohol use disorder (AUD) is a major public health concern both in terms of its impact on personal and family relationships and its tremendous economic costs due to lost productivity and health-related impairments. Improving the effectiveness of treatment of AUD requires improving our understanding of the neurobiological basis of addiction and the limitations of currently available intervention approaches. The proposed project will provide advanced training to both clinical and basic science researchers that will provide them with the knowledge base and research skills to investigate the neurobiology of addiction and develop improved therapeutic strategies to treat AUD.

PI_NAMEs: WOODWARD, JOHN J. (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: alcohol research;Training

PROJECT_TITLE: Training in Alcohol Research


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Disability Research;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Parkinson disease (PD) is a common neurodegenerative disorder affecting at least 1% of the population above the age of 60. There is no effective treatment for dementia and falls, leading to residential care placements, substantial morbidity and mortality. This study utilizing non-invasive imaging techniques will investigate novel brain pathways to identify at-risk PD patients before these disabling symptoms manifest and ultimately help develop effective, targeted therapies.

PI_NAMEs: MAITI, BAIJAYANTA  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;Age;Alzheimer's disease related dementia;Area;association cortex;base;Behavior;behavior measurement;Biological Markers;brain pathway;Brain region;Cell Nucleus;Cerebellar vermis structure;cholinergic;Clinical;clinical heterogeneity;clinical predictors;clinical trial participant;Cognition;Cognitive;cognitive impairment in Parkinson's;comparison control;Corpus striatum structure;Data;Dementia;Denervation;Development;Disabling;disabling symptom;Economic Burden;effective therapy;Ensure;falls;Functional disorder;Funding;Future;Gait;Gait abnormality;Goals;Human;imaging biomarker;Imaging Techniques;Impaired cognition;Impairment;in vivo;Individual;Lateral;Link;Longitudinal Studies;Manuscripts;Measures;Mentors;Midbrain structure;Morbidity - disease rate;mortality;Motor;motor disorder;Multimodal Imaging;multimodality;nerve supply;Neurodegenerative Disorders;neuroimaging;Neurotransmitters;nigrostriatal dopaminergic pathway;nigrostriatal pathway;non-invasive imaging;novel;Parkinson Disease;Parkinson's Dementia;Pathology;Pathway interactions;Patients;Physicians;Population;Positron-Emission Tomography;prognostication;Quality of life;Refractory;Research;Residential Treatment;Rest;Risk;Role;Scientist;socioeconomics;statistics;supportive environment;System;targeted treatment;Testing;Therapeutic;therapeutic target;Time;Training;Work

PROJECT_TITLE: Cerebellar cholinergic connections as a biomarker of dementia and gait impairment in Parkinson disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Childhood Injury;Clinical Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Suicide;Suicide Prevention

PI_NAMEs: RICHARDSON, LAURA P (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;Adolescent and Young Adult;Adolescent Risk Behavior;Age;age group;Algorithms;Ambulatory Care Facilities;Attention;Behavior;Caring;Child;Childhood;Clinic;clinical care;Clinical Pathways;coping;Counseling;design;Detection;Development;digital platform;digital tool;efficacy testing;Electronics;Emergency department visit;empowerment;Environment;Feeling suicidal;follow-up;Future;Goals;Health Personnel;High School Student;human centered design;implementation design;improved;improved outcome;Intervention;Medical;Mental Health;Monitor;mortality;Outcome;Outpatients;Parents;Pathway interactions;Pilot Projects;pilot test;Practice Guidelines;primary outcome;Procedures;Process;prototype;Provider;Qualitative Research;Recommendation;Registries;Reporting;Research;Risk Management;risk stratification;Safety;safety assessment;safety net;screening;Screening procedure;Screening Result;Self Efficacy;Self Management;shared decision making;Specialist;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surveys;System;Technology;Testing;therapy development;Time;timeline;tool;Training;treatment as usual;usability;Work

PROJECT_TITLE: Development and Pilot Testing of an Integrated Suicide Assessment and Safety Plan Digital Tool for Adolescent Outpatients


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Methamphetamine;Opioid Misuse and Addiction;Opioids;Patient Safety;Prescription Drug Misuse;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE Many individuals with substance use disorders (SUDs) do not seek treatment in specialty SUD treatment programs, particularly those in rural settings and those with co-occurring medical and mental health conditions. The integration of SUD treatment into healthcare settings under the ACA-driven healthcare reform requires research to identify, engage, and treat individuals with SUDs more effectively within primary and acute care settings, using electronic medical records to identify individuals at risk and utilizing novel treatment and technology approaches to address their substance use disorders

PI_NAMEs: HATCH, MARY AKIKO (contact);ROLL, JOHN M.

PROGRAM_OFFICER_NAME: BERTZ, JEREMIAH WILLIAM

PROJECT_TERMS: acute care;addiction;Address;Adoption;Affordable Care Act;Alaska Native;Alaska Native population;Alcohol abuse;Alcohols;American Indians;Area;Behavior Therapy;behavioral health;care providers;Caring;Chronic Disease;Clinical;clinical care;clinical practice;Clinical Research;clinical research site;Clinical Treatment;Clinical Trials Network;collaborative care;Communities;comparative effectiveness;Computerized Medical Record;Dependence;design;Disease;Disease Management;Drug abuse;drug of abuse;Drug Prescriptions;effective therapy;effectiveness evaluation;effectiveness testing;effectiveness trial;efficacy study;Electronic Health Record;electronic medical record system;Equity;Ethnic Origin;Face;Goals;health care delivery;Health Care Reform;health care settings;Healthcare;Healthcare Systems;Hepatitis C virus;Heroin;HIV;Individual;Information Dissemination;innovation;Institution;integrated care;Intervention;Libraries;Link;Marijuana;Medical;Medical Marijuana;medical specialties;medication-assisted treatment;Mental Depression;Mental Health;Methamphetamine;methamphetamine use;Mission;Modeling;Multi-Institutional Clinical Trial;National Clinical Trials Network;National Institute of Drug Abuse;novel;Opioid;opioid epidemic;opioid use;opioid use disorder;overdose risk;Pacific Northwest;parity;Pathway interactions;patient population;Patients;Pharmacological Treatment;physical conditioning;polysubstance use;Population;practice-based research network;Pragmatic clinical trial;prescription opioid misuse;Prevalence;Prevention;Primary Care;primary care practice;Process;programs;Provider;Race;Recovery;Recreation;Registries;Research;Research Personnel;Research Priority;Risk;Rural;rural area;rural setting;screening, brief intervention, referral, and treatment;sexual minority;Site;Substance abuse problem;Substance of Abuse;substance use;Substance Use Disorder;System;Technology;Technology Transfer;Training;translational pipeline;Translational Research;treatment program;Universities;Washington;Woman

PROJECT_TITLE: Clinical Trials Network: Pacific Northwest Node


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences;Prevention

ORG_DEPT: OTOLARYNGOLOGY

PHR: Project Narrative:  Noise trauma is a leading cause of hearing disorders for which there are no cures, underscoring the need for prevention, but there are no FDA-approved pharmacological interventions to prevent hearing loss. We have shown that specific neurotransmitter receptors in the cochlea can be antagonized to prevent noise trauma while others remain active to mediate hearing, however, local delivery of drugs to a healthy cochlea is too invasive and systemic dosing is only tolerated if side effects can be avoided. This proposal investigates the precise molecular composition of AMPA-type glutamate receptor pore-forming and auxiliary subunits in the cochlea, so that they may be specifically targeted with systemic pharmacology.

PI_NAMEs: RUTHERFORD, MARK ALLEN (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acids;Acoustic Nerve;Acute;Address;Adhesions;Affect;Anatomy;antagonist;Antioxidants;Basic Science;Cells;channel blockers;Chronic;Cochlea;cochlear development;cochlear synaptopathy;Collaborations;Combined Modality Therapy;Complement;Complex;Data;design;Discipline;Dose;Drug Delivery Systems;Ear;Electrophysiology (science);Excitatory Amino Acid Antagonists;excitotoxicity;Family;FDA approved;Functional disorder;Funding;Genetic;Glutamate Receptor;Glutamates;Goals;Hearing;Hearing problem;Heterogeneity;Histology;in vivo;International;Intervention;Investigation;Knockout Mice;Knowledge;Labyrinth;local drug delivery;Measures;Mediating;Molecular;Morphology;mouse genetics;Mus;Nerve Fibers;Nervous System;neuroligin 1;neuroligin 3;neurophysiology;Neurotransmitter Receptor;Noise;noise exposure;noise trauma;patch clamp;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiological;Physiology;Polyamines;postsynaptic;prevent;prevent hearing loss;Prevention;Property;Proteins;Proteomics;receptor;Recombinants;Resistance;response;Role;side effect;small molecule;sound;stargazin;Structure;Synapses;Synaptic Transmission;Testing;tool;translational potential;transmission process

PROJECT_TITLE: Excitability and Excitotoxicity in Type-I Cochlear Afferents: Synapse Structure and Function

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Circadian Effects in the Stroke Penumbra Almost all stroke experiments in rats and mice are performed during the day-time. For nocturnal rodents, this is their inactive phase. Almost all stroke patients are also recruited to neuroprotection trials in the day-time. But for diurnal humans, this is their active phase. Recently, we proposed that this “circadian mismatch” between rodent models and clinical trials may contribute to translational failure for neuroprotection. In this project, we will dissect the mechanisms that mediate circadian effects in the stroke penumbra, focusing on neuroprotection, blood flow regulation, cell death, and the exploration of novel targets in active-phase strokes.

PI_NAMEs: LO, ENG H. (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Affect;Animal Housing;antagonist;Antioxidants;Apoptosis;Apoptotic;ARNTL gene;Astrocytes;Autoradiography;awake;behavioral outcome;Bioinformatics;Blood flow;Blood specimen;Blood Vessels;Brain;candidate identification;CCL2 gene;Cell Death;Cells;Cerebral endothelium;Cerebral Ischemia;circadian;circadian biology;circadian regulation;Circadian Rhythms;Clinical;Clinical Trials;Cyclic AMP;Data;deprivation;Disease;Endothelium;Epinephrine;Etiology;Evolution;excitotoxicity;experimental study;Failure;Female;gain of function;Gene Expression;Genes;Glucose;Glutamates;Heart;hemodynamics;Hemostatic function;Histopathology;Human;Hydrocortisone;Hypercapnia;In Vitro;in vivo;Infarction;Ischemia;ischemic injury;Ischemic Stroke;Knockout Mice;Knowledge;lead candidate;Link;Liver;loss of function;male;Maps;Measures;Mediating;Mediator;Metabolism;MK801;Mus;N-Methylaspartate;Nature;Neurologic;Neurological outcome;Neurons;neuroprotection;Neuroprotective Agents;neurovascular unit;novel;optical imaging;Oxidative Stress;Oxygen;Paper;Patient Recruitments;Patients;Pattern;Perfusion;Peripheral;pharmacologic;Phase;Physiology;Plasminogen Activator Inhibitor 1;Proteins;Publishing;Rattus;Reactive Oxygen Species;recruit;Regulation;Research;response;reuptake;Rodent;Rodent Model;Role;sensor;shear stress;Signal Transduction;Sleep;Small Interfering RNA;Stroke;stroke patient;superoxide dismutase 1;Telemetry;Temperature;Terminology;Testing;Time;tissue injury;tool;treatment response;Up-Regulation;Vasodilation;Vibrissae;Western Blotting

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: NARRATIVE:  Loud sounds can damage both middle- and inner-ears and cause temporary or permanent hearing loss, however, little is known of how the middle ear transmits these harmful sounds to the inner ear. Ear surgeons can repair damaged middle ears with reconstruction surgeries, but how well these reconstructed ears work at high level sounds has not been well described. Understanding responses of normal and reconstructed middle ears to loud sounds can help better predict noise-induced hearing damage, develop new strategies for ear protection and improve the repair of sound-damaged middle ears.

PI_NAMEs: CHENG, JEFFREY TAO (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: 3-Dimensional;Anatomy;Auditory;Cadaver;clinically significant;Cochlea;Conductive hearing loss;Coughing;Dependence;Development;Diving;Ear;ear muscle;Elements;Etiology;Exposure to;External auditory canal;Failure;Frequencies;Growth;Hearing;hearing impairment;Holography;Human;improved;Impulsivity;Joints;Knowledge;Labyrinth;Lasers;Lead;Ligaments;Loudness;mathematical model;Measurement;Measures;middle ear;Modeling;Motion;Noise;Non-linear Models;Nose;novel;Operative Surgical Procedures;Ossicular Replacement Prosthesis;Perforation;permanent hearing loss;Play;pressure;prevent;Prevention;Process;Prosthesis;reconstruction;Reconstructive Surgical Procedures;Recording of previous events;Reflex action;repaired;Reporting;Research;response;Role;Rupture;Series;Severities;Signal Transduction;Sneezing;soft tissue;sound;Speed;Stapes;Stimulus;structural determinants;Structure;Surgeon;Techniques;Temporal bone structure;Tendon structure;Testing;Time;Tissues;transmission process;Tympanic membrane;Tympanic Membrane Perforation;vibration;Work

PROJECT_TITLE: Middle Ear Nonlinearity in High Intensity Sound: Impact on Hearing Damage and Protection


ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: The goal of this grant is to train alcohol research scientists. Training scientists in alcohol research methods is essential to understanding the complex nature of binge drinking and alcohol use disorder. Multi-disciplinary training in molecular mechanisms of alcoholic pathology will cover fetal, brain, genetic, behavioral and other pathologies involved in long-term drinking.

PI_NAMEs: CREWS, FULTON T;KASH, THOMAS L.;ROBINSON, DONITA L (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TITLE: Molecular and Cellular Alcohol Research Training


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Public Health Relevance The epidemic of obesity is affecting more than one third of the adults in the US. Common obesity is usually accompanied by elevated circulating levels of leptin, the primary adipostatic factor in mammals, however resistance to leptin develops, preventing the maintenance of normal body weight. This application explores methods for augmenting leptin sensitivity, which may represent a safe and effective means of treating obesity.

PI_NAMEs: CONE, ROGER D. (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acyl Coenzyme A;Adipose tissue;Adult;Affect;Anatomy;Animals;Anti-diabetic Drugs;Anti-Obesity Agents;Applications Grants;Attenuated;Basic Science;Binding;Biochemical;biological adaptation to stress;Blood - brain barrier anatomy;blood glucose regulation;blood-brain barrier permeabilization;Body Weight;Body Weight decreased;Brain;Brain region;Cardiovascular Diseases;Cells;Clinical Research;combat;comorbidity;Data;db/db mouse;Deacetylase;design;Development;Diabetes Mellitus;diabetic;Diazepam Binding Inhibitor;diet-induced obesity;Disease;drug action;Drug Targeting;Eating;Eating Disorders;Economic Burden;Energy Metabolism;Fatty acid glycerol esters;Fatty Liver;Functional disorder;Genes;Genetic;Genetic Transcription;HDAC6 gene;heat-shock factor 1;Heat-Shock Response;Homeostasis;Hormones;Hypothalamic structure;improved;inhibitor;Knockout Mice;Lead;Leptin;leptin receptor;Leptin resistance;Liver;Maintenance;Malignant Neoplasms;Mammals;Mediating;Mediator;Metabolic;Methods;Modeling;Molecular;mouse model;Mus;mutant;Neurons;novel;novel therapeutic intervention;nuclear factor-erythroid 2;Obese Mice;obese person;Obesity;Obesity Epidemic;obesity treatment;Outcomes Research;Overweight;Oxidative Stress;paralogous gene;Pathway interactions;Peripheral;pharmacologic;Phenotype;Population;prevent;Process;Protein Tyrosine Kinase;proteostasis;public health relevance;Receptor Signaling;Regulation;Resistance;response;Risk Factors;Rodent Model;Role;Signal Transduction;Site;small molecule;Stress;Testing;Therapeutic;Thinness;Tissues;Transcript;transcriptome;transcriptomics;Wild Type Mouse;Work

PROJECT_TITLE: Role of HDAC6 in the Regulation of Energy Homeostasis and Leptin Sensitivity

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The ability to robustly, selectively and flexibly encode visual information is fundamental to our sense of vision. We will bring state-of-the-art imaging approaches to reveal how functional convergence of distinct sources of inputs may reinforce the computation of select channels of visual information. Our studies will contribute to the understanding and treatment of various neurological and psychiatric disorders that involve inappropriate connectivity pattern formation and abnormal signal integration.

PI_NAMEs: LIANG, LIANG  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Animals;Arousal;awake;Axon;Behavior monitoring;Behavioral;Biophysics;Brain;Brain region;Calcium;calcium indicator;Calcium Signaling;Chronic;Color;Conscious;Dendrites;Dorsal;Esthesia;experimental study;Eye;Face;flexibility;Foundations;Future;Genetic;Goals;Head;Image;imaging approach;imaging platform;Individual;innovation;interest;Knowledge;Lateral Geniculate Body;Locomotion;Logic;Mammals;Measures;Mental disorders;Methodology;Methods;Midbrain structure;Modeling;Movement;Mus;Nervous System Disorder;neural;neural circuit;neurodevelopment;Neurons;novel;optogenetics;Pattern Formation;Play;preference;Process;Property;receptive field;Resolution;response;restraint;Retina;retinal axon;retinogeniculate;Role;Route;Sensory;Shapes;Signal Transduction;Source;spatial relationship;Stream;superior colliculus Corpora quadrigemina;Synapses;Testing;Thalamic structure;Travel;two-photon;Vision;Visual;Visual Cortex;Visual evoked cortical potential;visual information;Visual Perception;visual processing;Visuospatial;Work

PROJECT_TITLE: Functional circuitry and computation of the visual thalamus

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative / Lay Language Description Trachoma is the leading cause of infectious blindness worldwide and has been targeted for global elimination as a public health problem by 2030. Population-level assessment of trachoma through antibodies in blood is a promising approach to monitor transmission as countries approach and achieve elimination. We will combine information across 19 separate field studies (>100,000 people, mainly in Africa) to develop summary methods that translate antibodies in blood into population-level measures of trachoma endemicity, and determine if using spatial information in the design and analysis of serologic surveys could improve their usefulness to trachoma control programs.

PI_NAMEs: ARNOLD, BENJAMIN F (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Advisory Committees;Africa;Age;age related;Antibiotics;Antibodies;Antibody Response;Antigens;Area;assay development;Azithromycin;Blindness;Blood;Blood specimen;Centers for Disease Control and Prevention (U.S.);Child;Chlamydia trachomatis;Clinical;Communities;computer studies;Country;Data;Data Set;Decision Making;design;Diagnosis;Disease;Ensure;Epidemiologic Methods;Epidemiology;Ethiopia;Evolution;field study;Geography;global health;Heterogeneity;immunogenic;Immunoglobulin G;Immunology;improved;Individual;Infection;interest;International;Knowledge;Language;Measures;meetings;member;Methods;Modeling;Molecular;Monitor;multiplex assay;Niger;novel strategies;Pattern;Persons;Phase;Play;Population;population based;Population Programs;Prevalence;programs;Public Health;Recombinants;Research;Sampling;semiparametric;Series;seroconversion;Seroepidemiologic Studies;Serology;Seroprevalences;serosurveillance;serosurvey;Statistical Methods;Structure;Surveys;Symptoms;Testing;Time;Trachoma;Translating;transmission process;Work;World Health Organization

PROJECT_TITLE: Seroepidemiology of trachoma for the elimination endgame

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Only a minor fraction of immunocompetent humans develop tuberculosis with massive necrotic granulomas and cavitation in their lungs, but the host mechanisms causing this vulnerability are poorly characterized. We will use a well characterized mouse model that recapitulates the formation of organized necrotic pulmonary tuberculosis (TB) granulomas to examine the interplay of host mechanisms of susceptibility with the necrosis-inducing factor of virulent Mycobacterium tuberculosis (Mtb). Because necrosis of TB granulomas is a major obstacle to the sterilization of TB lesions with antibiotics, this study will lead to host-directed therapies that will synergize with antibiotics to shorten and improve TB chemotherapy.

PI_NAMEs: KRAMNIK, IGOR  (contact);NIEDERWEIS, MICHAEL

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Aerosols;Antibiotics;Antioxidants;Automobile Driving;Cause of Death;Cells;Cessation of life;Data;Dissection;Drug resistance;Drug resistance in tuberculosis;Evolution;Ferritin;Genetic;Genetic Transcription;genomic locus;Goals;Granuloma;Human;human model;Hydrolysis;Hyperactivity;Immune;Immune response;Immunity;Immunocompetent;Immunologics;Impairment;improved;improved outcome;In Vitro;in vivo;Inbred Mouse;Individual;Inflammatory;Interferon Type I;Intervention;Iron;Knowledge;Laboratories;Lead;Lesion;Link;Lipid Peroxidation;Lung;Macrophage;Mediating;Minor;mouse genetics;mouse model;Mus;mutant;Mycobacterium tuberculosis;NADP;Necrosis;Necrosis Induction;non-necrotizing granulomas;Outcome;oxidative damage;pathogen;Pathogenesis;Pathway interactions;Pattern;Population;Predisposition;prevent;Production;proteostasis loss;Pulmonary Tuberculosis;Reporter;resilience;Resistance;response;Role;Sterilization;stress resilience;success;Susceptibility Gene;synergism;Testing;Therapeutic;Tissues;TNF gene;Toxin;transmission process;Tuberculosis;tuberculosis chemotherapy;tuberculosis granuloma;Virulence;Virulent;Visualization

PROJECT_TITLE: Necrosis in Pulmonary TB granulomas: dynamics, mechanisms, and therapies

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Post-translational modification of proteins by methylation regulates diverse signaling pathways that play important roles in human health and disease. We propose to investigate the molecular mode of action for several key protein methylase enzymes in mammalian cells. This proposal will provide insights into how protein methylation regulates fundamental cellular functions, including chromatin dynamics, and has the potential to identify new and clinically actionable targets to treat cancers and other pathologies.

PI_NAMEs: GOZANI, OR P. (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Biochemical;Biological Process;Biology;Cell model;Cell Physiology;Cellular biology;Chromatin;clinically actionable;Disease;Enzymes;Epigenetic Process;Gene Expression;gene translocation;Genomics;Goals;Health;Histidine;Histone H3;histone methylation;Homeostasis;Human;human disease;Human Genome;insight;Link;Lysine;Malignant Neoplasms;Mammalian Cell;Methylation;Methyltransferase;Modification;Molecular;mouse model;multidisciplinary;Mutation;non-histone protein;Pathogenesis;Pathology;Physiological;Play;Post-Translational Protein Processing;protein function;Protein Methylation;Protein Methyltransferases;Proteins;Proteomics;Regulation;Research;Role;Signal Pathway;Signal Transduction;Source

PROJECT_TITLE: Function of Protein Methylation in Chromatin and Signaling Regulation


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Malaria is a leading cause of illness and death for children under five years of age globally, with most of these deaths resulting from infection by the Plasmodium falciparum parasite. The goal of this application is to improve our understanding of how the transmission stage of malaria parasites develops. By understanding the unique features of transmission stage development, we can identify proteins and processes that can be targeted by future therapies to block malaria from spreading.

PI_NAMEs: DVORIN, JEFFREY D (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: 3-Dimensional;5 year old;asexual;Biogenesis;Biophysics;Blood;Cell membrane;Cellular Morphology;Cessation of life;Child;Complex;Culicidae;Cytoskeleton;Defect;Development;Electron Microscopy;Epitopes;Erythrocytes;Female;Filament;Future;Gene Proteins;Genes;Goals;Human;Image;Immunofluorescence Immunologic;improved;Infection;Ingestion;Intermediate Filaments;Investigation;Ions;knock-down;Knock-out;Label;Life Cycle Stages;Malaria;male;Measures;member;Membrane;Microfabrication;Microtubules;Molecular;Morbidity - disease rate;Morphology;mortality;Multiprotein Complexes;Names;novel;novel strategies;Parasites;Pathway interactions;Plasmodium falciparum;Platinum;Population;Process;Proteins;resilience;reverse genetics;Scanning Electron Microscopy;Series;Shapes;Techniques;Testing;Transgenic Organisms;Transmission Electron Microscopy;transmission process;Vesicle;Visualization;Width

PROJECT_TITLE: Functional investigation of a novel and essential subcellular compartment in Plasmodium falciparum transmission stage parasites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-H(02)]


ADMINISTERING_IC: HS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Developing culturally responsive, acceptable and feasible interventions to promote school readiness is key to reducing the disparities that exist in educational attainment of Latino children living in poverty. The studies described will develop and pilot test a school readiness program based in primary care for Spanish speaking parent-child dyads that is centered on the preferences of Latino parents, their pediatric providers and early childhood educators.

PI_NAMEs: PETERSON, JAIME  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Latino School Readiness: Engaging Pediatric and Early Childhood Systems to Adapt and Pilot Family Centered Primary Care Interventions

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Genetics;Human Genome;Immunotherapy;Women's Health Research

ORG_CITY: EVANSTON

ORG_NAME: ENDEAVOR HEALTH CLINICAL OPERATIONS

ORG_STATE: IL

PHR: PROJECT NARRATIVE In recent years there has been a significant interest in developing anti-checkpoint inhibitors such as anti-PD-1 and anti-CTLA-4 for the treatment of breast cancer. Although some triple negative breast cancer patients respond well to these treatments, most women are resistant to this therapy. We are proposing to develop a safe and effective virus in combination with anti-immune checkpoint inhibitors for the treatment of triple negative breast cancer. This will lead to future combination therapy trials with anti-PD-1 and anti-CTLA-4 in breast cancer patients.

PI_NAMEs: XU, WEIDONG  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: 4T1;Abraxane;Adenoviruses;Amino Acids;anti-CTLA-4 therapy;anti-CTLA4;anti-PD-1;anti-PD-1/PD-L1;anti-PD-L1;anti-PD-L1 antibodies;anti-PD1 antibodies;anti-tumor agent;anti-tumor immune response;Antibodies;Antibody titer measurement;Antitumor Response;Attenuated;Binding;Biological Assay;Biological Markers;biomarker selection;bone;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;Cell Death;Cells;Clinical;Clinical Trials;Combination immunotherapy;Combined Modality Therapy;Complementarity Determining Regions;CTLA4 gene;cytokine;Cytometry;Development;FDA approved;Fiber;Future;gene panel;Genes;Genetic Transcription;Goals;Hepatic;Homing;Human;Immune;immune activation;Immune checkpoint inhibitor;immunogenicity;Immunoglobulin G;Immunologics;Immunology procedure;Immunophenotyping;Immunosuppressive Agents;improved;in vivo;Inflammatory;interest;Liver;Lymphatic;Macrophage;Malignant Neoplasms;Mammary Neoplasms;Mediating;Metastatic Neoplasm to the Bone;Modeling;molecular subtypes;Mus;nano-string;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;Normal tissue morphology;novel;novel therapeutics;Oncogenes;oncolytic adenovirus;Oncolytic viruses;Osteolytic;Paclitaxel;Pathway interactions;Patients;Peptides;peripheral blood;Phenotype;Population;Prevalence;programmed cell death ligand 1;programmed cell death protein 1;receptor;Research;research clinical testing;Resistance;response;RNA;Role;Safety;Signal Pathway;Signal Transduction;Spleen;subcutaneous;systemic toxicity;Technology;Testing;TGFB1 gene;Therapy Clinical Trials;therapy resistant;Therapy trial;Toxic effect;transcriptome;transcriptome sequencing;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor specificity;uptake;Viral;Virus;Woman

PROJECT_TITLE: Systemic delivery of an oncolytic adenovirus targeting TGFβ to enhance anti-PD-1 and anti-CTLA-4 therapy for triple negative breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

PHR: Narrative/Public Health Relevance Statement Current ultrasonic fetal imaging methods provide inadequate visualization of important fetal structures in many patients. We propose to develop new imaging techniques to improve image quality and characterize the sources of image degradation.

PI_NAMEs: TRAHEY, GREGG E. (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Abdomen;Affect;Aneuploidy;Anxiety;Blinded;Cardiac;Cesarean section;Clinical Research;Clutterings;comparative;Congenital diaphragmatic hernia;cost;Counseling;Data;Detection;Developed Countries;Diagnosis;Diagnostic;Diffuse;Discipline of obstetrics;Environment;Failure;fetal;Fetal Development;Fetal Growth;Fetal health;Fetal Monitoring;Fetal Structures;Fetal Viability;Fetus;First Pregnancy Trimester;follow-up;Frequencies;Gestational Age;Human;Image;Image Analysis;imaging modality;Imaging Techniques;improved;in vivo;Life;Location;Maps;Maternal Health;maternal outcome;Measures;Methods;Morbidity - disease rate;mortality;Mothers;Multiple Pregnancy;neonate;Noise;novel;Obesity;Operative Surgical Procedures;Ovary;Overweight;Pathology;Patient imaging;Patients;Pelvis;Placenta;postnatal;Pregnancy;Property;public health relevance;Publishing;quantitative imaging;Research;Resolution;Role;Scanning;Second Pregnancy Trimester;simulation;Source;Structure;Sum;Techniques;tertiary care;theories;Translations;Ultrasonics;Ultrasonography;ultrasound;United States;unnecessary treatment;Uterus;Visualization;Woman

PROJECT_TITLE: Coherence-Based Fetal Ultrasonic Imaging

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Bioengineering;Genetics;HIV/AIDS;Immunization;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: This proposal describes the improvement and adaptation of a high throughput single cell analysis technology for simultaneous and multiplexed measurement of proteins, protein complexes and mRNA in thousands of individual cells, and studying key hypotheses on the development and signaling in hematopoietic stem cells and germinal center B cells. We will characterize thousands of key protein species regulating pro- inflammatory signaling responses and development in cells from the hematopoietic lineage and the germinal center, and combine this data with mathematical modeling and live-cell imaging to understand mechanisms underlying signal-specific gene regulation, variability and dynamics. Our practical and broadly applicable technology will rapidly and quantitatively evaluate a vast space of proteomic states, generate improved insight on the signaling and evolution of immune networks, and make a substantial impact into understanding and modeling of infection, autoimmunity, immune development and emergence of drug resistance.

PI_NAMEs: CLARK, MARCUS RAMSAY;TAY, SAVAS  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adaptor Signaling Protein;Antigens;Autoimmunity;B cell differentiation;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Bar Codes;CD19 gene;CD22 gene;Cell Physiology;cell type;Cells;Clinical Research;Complex;computerized tools;cytokine;Data;Dendritic Cells;Development;DNA;Drug resistance;Endothelial Cells;Epithelial Cells;Event;Evolution;Exclusion;experimental study;extracellular;Gene Expression;Gene Expression Regulation;Genetic Transcription;Goals;granulocyte;granulocyte-monocyte progenitors;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;Heterogeneity;Human;Immune;immune activation;Immune signaling;Immunity;improved;Individual;Infection;Inflammatory;insight;IRF3 gene;Joints;live cell imaging;Lung;Macrophage;Malignant Neoplasms;MAP Kinase Gene;MAPK8 gene;Maps;mathematical model;Measurement;Measures;member;Messenger RNA;Methods;MHC Class II Genes;Modeling;monocyte;Mus;Noise;p38 Mitogen Activated Protein Kinase;Pathway interactions;Peripheral Blood Mononuclear Cell;Phosphotransferases;PIK3CG gene;Population;Post-Translational Protein Processing;Process;Productivity;progenitor;programs;Proliferating;protein complex;protein expression;Proteins;Proteomics;receptor;Receptor Signaling;response;Rest;RNA;Signal Pathway;Signal Transduction;Signaling Protein;single cell analysis;single cell mRNA sequencing;single cell sequencing;Specificity;Structure of germinal center of lymph node;Surface;T-Lymphocyte;Technology;Testing;TLR4 gene;Toll-like receptors;trafficking;transcription factor;transcriptome;tumor

PROJECT_TITLE: Comprehensive characterization of immune signaling networks in single-cells by joint quantification of proteins, protein complexes and mRNA

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Infectious Diseases;Neurosciences

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: As animals navigate their environments, their nervous systems transition between a wide range of internal states that influence how sensory information is processed and how behaviors are generated. While virtually all animals organize their behavioral outputs in this state-like fashion, it remains unclear how internal states are generated and how they are able to influence behavior. Here, we propose to examine how brain-wide activity encodes the diverse motor programs of C. elegans across a range of aversive internal states, which should enhance our fundamental understanding of how the nervous system encodes behavior and how internal states influence the neural circuits that encode behavior.

PI_NAMEs: FLAVELL, STEVEN WILLEM (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TITLE: Brain-Wide Representations of Behavior During Aversive Internal States in C. Elegans

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE This proposal will test the hypothesis that learning and memory can be improved by using computationally designed training protocols that optimize the interactions between kinase cascades and transcription factors involved in the induction of long-term memory (LTM). These predictions, combined with concurrent empirical tests, will provide a proof of principle for an efficient strategy to enhance learning and improve memory retrieval.

PI_NAMEs: BYRNE, JOHN H (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Adult;Amnesia;Amygdaloid structure;anxiety-related disorders;Aplysia;Avoidance Learning;Biological Models;Brain;clinically relevant;Complex;Computer Models;conditioned fear;conditioning;Cyclic AMP-Dependent Protein Kinases;Data;design;experimental study;Extinction;Extracellular Signal Regulated Kinases;fear memory;forgetting;Fright;Genetic Transcription;Hippocampus;Human;Impaired cognition;improved;in vivo;in vivo evaluation;Individual;infancy;Infant;infant animal;innovation;insight;Intervention;Learning;long term memory;Memory;memory consolidation;Memory impairment;memory retrieval;Mental disorders;Mitogen-Activated Protein Kinases;Modeling;Molecular;molecular modeling;multidisciplinary;novel;Patients;pharmacologic;Phosphotransferases;Process;Protein Dynamics;Protein Isoforms;Protocols documentation;Rattus;Regulation;Rodent;Series;Signal Pathway;Signal Transduction;simulation;stem;Stimulus;Synapses;Synaptic plasticity;System;Testing;Time;Training;transcription factor;Work

PROJECT_TITLE: Modeling the Molecular Networks that Underlie the Formation and Consolidation of Memory


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Dissemination and Implementation Research;Emergency Care;Health Services;Lung;Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE There is substantial variability in adherence to evidence-based clinical management leading to inconsistent quality of care for acute respiratory failure. Using implementation science methodology, Dr. Goel’s K23 research aims to enhance adherence to evidence-based guidelines and improve care and clinical outcomes for patients presenting to the emergency departments with acute respiratory failure.

PI_NAMEs: GOEL, NEHA NEELAM (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;acute hypoxemic respiratory failure;Acute respiratory failure;Address;Adherence;care delivery;career;career development;Caring;Censuses;Clinical;clinical application;Clinical Investigator;Clinical Management;cohort;Consolidated Framework for Implementation Research;COVID-19 pandemic;Critical Care;Critical Illness;Data;design;Development;Development Plans;Effectiveness;effectiveness testing;effectiveness/implementation study;Emergency Care;Emergency Department patient;Emergency research;Ensure;evidence base;evidence based guidelines;Evidence based practice;Failure;Feedback;Focus Groups;Funding;Future;Goals;Guidelines;Health system;Hospitals;implementation evaluation;implementation process;implementation science;implementation strategy;improved;Intensive Care Units;International;Interruption;Intervention;Intubation;Lung;Mechanical ventilation;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Monitor;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;Nose;Outcome;Oxygen;Patient Care;Patient-Focused Outcomes;Patients;Phase;Physicians;pilot test;Positioning Attribute;pressure;Process;Process Measure;Protocols documentation;Provider;Quality of Care;Recommendation;Research;Research Personnel;Research Project Grants;research study;Resources;respiratory;Sample Size;Sampling;Scientist;Shock;skills;standardized care;Statistical Data Interpretation;Testing;Time Series Analysis;Training;United States;ventilation;Work;Workload

PROJECT_TITLE: Optimizing the use of noninvasive respiratory support in the Emergency Department

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Aging;Genetics

PHR: The main objective is to investigate the mitochondrial signaling mechanism that regulates cell fate determination associated with cellular senescence.

PI_NAMEs: WANG, XIAO-FAN ;YAO, TSO-PANG  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Adopted;Affect;age acceleration;Aging;ataxia telangiectasia mutated protein;Cell Aging;cell injury;Cell Nucleus;Cells;chemokine;cytokine;Cytosol;Defense Mechanisms;Degenerative Disorder;DNA;DNA biosynthesis;DNA Damage;DNA Sequence Alteration;Extravasation;Gene Expression Profiling;Genes;Growth;human old age (65+);Inflammatory;Lamin B1;Lamin Type A;Left;Maintenance;Mediating;Mitochondria;Mitochondrial DNA;Modeling;Morphology;Mus;NF-kappa B;novel;Nuclear;Nuclear Envelope;Nuclear Lamin;Nuclear Lamina;Nucleotides;old mice;Pathway interactions;pharmacologic;Phenotype;Physiological;Ploidies;Premature aging syndrome;prevent;Process;Production;Progeria;programs;Regulation;response;Role;senescence;senescence associated secretory phenotype;senescent cell;Signal Transduction;Source;Stimulator of Interferon Genes;Stress;Testing;Tissues;TLR9 gene;tumorigenesis;Up-Regulation;Viral;Zalcitabine

PROJECT_TITLE: Roles of mitochondrial dynamics and mtDNA in senescence

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative: The DEK oncogene is over-expressed in ~60% of breast cancers as well as in all other solid tumors tested to date; however, the mechanisms by which it promotes tumor formation and growth are very poorly understood. We have recently identified that one potential mechanism of DEK-induced oncogenic phenotypes is the upregulation of Wnt expression and downstream pathway activation, which is a common occurrence in triple negative breast cancer. Importantly, we are the first to investigate how Wnt proteins may induce an M2-like polarization of tumor associated macrophages in order to convert the immune system into a tumor-promoting role rather than a tumor-fighting one. Understanding how DEK promotes tumorigenesis, including the potential relationship between Wnt signaling and anti-tumor immune responses from TAMs, will better inform treatment decisions and potentially maximize the therapeutic effect of combining immunotherapies and chemotherapy.

PI_NAMEs: PRIVETTE VINNEDGE, LISA M. (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Animal Model;anti-tumor immune response;autocrine;Blood Vessels;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;breast tumorigenesis;Cancer Biology;cancer cell;carcinogenesis;Cell Culture Techniques;Cell secretion;Cells;Chemicals;chemotherapy;chromatin remodeling;Collaborations;Combination immunotherapy;Coupled;Coupling;Cues;Cytotoxic T-Lymphocytes;Data;DEK gene;Development;differential expression;Disease;Disease Progression;Doxycycline;Environment;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;ERBB2 gene;fighting;Future;Gene Expression;Genes;Genetic;Gland;Goals;Growth;Histologic;Hormone Receptor;Hormones;Human;Hyperplasia;Immune;immune cell infiltrate;Immune system;improved;In Vitro;in vivo;in vivo evaluation;Infection;Inflammatory;Invaded;Knockout Mice;Ligands;longitudinal analysis;Macrophage;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mammary gland;Mammary Neoplasms;Mediating;Mediator;Mentored Clinical Scientist Development Program;migration;Modeling;Molecular;molecular array;molecular marker;mouse model;Mus;Myeloid Cells;Neoplasm Metastasis;neoplastic;neoplastic cell;Normal Cell;novel;Oncogenes;Oncogenic;Organoids;overexpression;paracrine;Paracrine Communication;Pathway interactions;Patients;Persons;Phenotype;prevent;Prognosis;programs;Proliferating;Proteins;receptor;recruit;Role;Sampling;Signal Induction;Signal Transduction;small hairpin RNA;small molecule inhibitor;Solid Neoplasm;Survival Rate;targeted treatment;Testing;Therapeutic;Therapeutic Effect;three dimensional cell culture;Tissue Microarray;Tissue Sample;Tissues;transcriptome sequencing;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor initiation;tumor progression;Tumor Promotion;Tumor-associated macrophages;Tumor-Derived;tumor-immune system interactions;tumorigenesis;tumorigenic;Up-Regulation;Wnt proteins;WNT Signaling Pathway;Work;Xenograft procedure

PROJECT_TITLE: Mechanisms coupling DEK to oncogenesis

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Schizophrenia;Sleep Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: A fundamental challenge to finding effective treatments for neuropsychiatric disorders is the paucity of biomarkers that can gauge whether a potential intervention affects abnormal circuitry early in the treatment development pipeline, before embarking on expensive and lengthy clinical trials. This research proposal will develop novel physiological assays of sleep-dependent memory consolidation in humans and rodents that can be used to predict the efficacy of newly emerging treatments. These assays will enable the efficient screening and identification of treatments that can alleviate highly disabling cognitive deficits in schizophrenia.

PI_NAMEs: MANOACH, DARA S (contact);VARELA, CARMEN

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Acoustic Stimulation;Address;Affect;Alzheimer's Disease;Animals;Auditory;autism spectrum disorder;Biological Assay;Biological Markers;Brain;brain circuitry;Cephalic;Clinic;clinical candidate;Clinical Trials;Cognition;Cognitive deficits;cognitive disability;Coupled;Coupling;Data;Data Set;density;Detection;Disease;Dose;drug development;Early Intervention;effective therapy;efficacy evaluation;Electric Stimulation;Electroencephalography;Electrophysiology (science);Epilepsy;Eszopiclone;Evaluation;Event;Follow-Up Studies;Future;Genetic study;Goals;Health;Hippocampus;Human;improved;improvement on sleep;Intervention;life span;Machine Learning;Measurement;Measures;Mediating;Memory;memory consolidation;Memory impairment;Nerve Degeneration;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuropsychiatric disorder;non rapid eye movement;novel;optogenetics;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Physiological;Play;Polysomnography;preservation;Rattus;Research;Research Proposals;response;Rodent;Scalp structure;Schizophrenia;screening;Sleep;Sleep disturbances;sleep spindle;therapeutic target;therapy development;Time;translation assay;Translations;Treatment Efficacy;Work

PROJECT_TITLE: Optimizing sleep spindle measurements as translational assays of memory consolidation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: PULLMAN

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: PROJECT NARRATIVE The lack of sleep is a pervasive societal issue that leads to both off- and on-the-job accidents and lost revenue from performance deficiencies. Poor sleep and sleep insufficiency are even risk factors for five of the eight leading causes of death in the US. Exactly how inadequate sleep affects the brain is enigmatic; therefore, in this project we will investigate key mechanistic pathways that underlie the negative impacts of poor sleep and sleep insufficiency on cognitive functioning.

PI_NAMEs: DAVIS, CHRISTOPHER JOHN (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Acceleration;Accidents;Adenosine;Affect;Animals;Area;awake;Behavior;Behavioral;Binding;Biochemical;Brain;Cause of Death;Cell membrane;cell type;Cells;Cognitive;cognitive function;cognitive performance;cognitive process;cognitive rigidity;Complex;Corpus striatum structure;Cyclic AMP;Data;Deceleration;Decision Making;Dopamine;Dopamine D2 Receptor;Dorsal;dorsal visual stream;Electrophysiology (science);Event;experimental study;Feedback;flexibility;Future;GABA Receptor;Genetic;Goals;Human;Image;in vivo;Lead;Literature;Measures;Mediating;Mediator;Modeling;Mus;neuronal excitability;Neurons;Occupations;Outcome;Output;Pathway interactions;Performance;poor sleep;Population;Predisposition;pressure;prevent;Primates;Publishing;Purinergic P1 Receptors;Rattus;receptor;receptor density;receptor expression;Recovery;Resistance;response;Risk Factors;Rodent;Role;Signal Transduction;Sleep;Sleep Deprivation;Sleep Wake Cycle;Solid;stem;Structure;Techniques;Testing;Time;touchscreen;Transgenic Mice;Whole Organism;Work

PROJECT_TITLE: THE ROLE OF MEDIUM SPINY NEURONS IN SLEEP DEPRIVATION-INDUCED COGNITIVE RIGIDITY.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-B(02)M]


NIH_SPENDING_CATS: Cancer;Eye Disease and Disorders of Vision;Genetics

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: We have discovered that Notch4 has distinct pro-angiogenic and inflammatory function that differ significantly from the negative angiogenic regulation mediated by Notch1. Endothelial Notch4 acts to promote ocular disease and tumorigenesis and may act primarily by influencing both endothelium and adjacent stromal cells. We will study how endothelial Notch4 facilitates formation of blood vessels and inflammatory responses, allowing us to understand how angiogenesis occurs in healthy individuals and human disease. Our goal is to develop Notch4 inhibition as a candidate strategy to inhibit tumor growth and control ocular inflammatory disorders such as retinopathy and corneal neovascularization.

PI_NAMEs: KITAJEWSKI, JAN K. (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: 3-Dimensional;Ablation;angiogenesis;Antibodies;Binding;Biological Assay;Biology;Blindness;Blocking Antibodies;blood vessel development;Blood Vessels;candidate selection;CCL2 gene;Cell Communication;Cells;Cleavage Under Targets and Release Using Nuclease;Corneal Injury;Corneal Neovascularization;cytokine;Cytokine Gene;Cytokine Signaling;Data;Databases;defined contribution;Development;Disease;Endothelial Cells;Endothelium;Eye diseases;Family;Flow Cytometry;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Goals;Growth;Hematological Disease;human disease;IL6 gene;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;inhibitor;insight;Leukocytes;loss of function;Macrophage;Malignant Neoplasms;Mediating;Messenger RNA;Microglia;Modeling;mouse model;Mus;mutant;Neoplasm Metastasis;neovascularization;notch protein;NOTCH1 gene;novel;novel therapeutics;ocular angiogenesis;Outcome;Pathologic Neovascularization;Pathway interactions;pharmacologic;Phenotype;pre-clinical;prevent;Proteins;Regulation;Regulatory Pathway;response;Retina;retinal angiogenesis;Retinal Diseases;Retinal Neoplasms;Retinopathy of Prematurity;Ribosomes;RiboTag;Role;Signal Pathway;Signal Transduction;Signaling Protein;single cell analysis;single-cell RNA sequencing;Specificity;Stromal Cells;Stromal Change;Structure;targeted treatment;Techniques;Technology;Testing;Therapeutic;therapy design;Tissues;Transcriptional Regulation;transcriptome;translatome;triple-negative invasive breast carcinoma;tumor;Tumor Angiogenesis;tumor growth;Tumor Promotion;Tumor-associated macrophages;tumorigenesis;Vascular Diseases;vascular inflammation;Visual impairment;Work

PROJECT_TITLE: Notch in Angiogenesis and Vascular Biology

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: LOWELL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

PHR: Social and behavioral determinants of health and Alzheimer’s Disease: Cohort study of the US military  veteran population Veterans are particularly susceptible to Alzheimer’s Disease (AD) due to demographic, clinical, and economic factors. Social determinants of health are the conditions in which people are born, live, work, and age. Adverse social determinants of health include job loss and financial and food insecurity. Together with behavioral health factors (e.g., smoking and substance use) and mental health, adverse social and behavioral determinants of health (SBDH) contribute to AD. Natural language processing approaches can be developed to automatically extract SBDH and their attributes to study the associations between SBDH and AD.

PI_NAMEs: YU, HONG  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Adult;Affect;Age;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease risk;Behavioral;behavioral health;Black American;case control;Cause of Death;Clinic;Clinical;Cohort Studies;cost;cost effective;Data;deep learning model;Dementia;dementia risk;design;Development;digital repositories;Dose;Early Diagnosis;Economic Factors;Electronic Health Record;electronic structure;ethnic minority;Ethnic Origin;experience;Exposure to;Financial Hardship;food insecurity;Generations;Health;Health Care Costs;health determinants;Health Surveys;Healthcare;Healthcare Systems;High Prevalence;high risk population;Homelessness;human old age (65+);Impaired cognition;improved;Incidence;Informatics;Infrastructure;innovation;Integrated Health Care Systems;intersectionality;Intervention;Job loss;Learning;Machine Learning;Maintenance;Measures;men;Mental Health;military veteran;Modeling;modifiable risk;Natural Language Processing;Neurology;Not Hispanic or Latino;Observational Study;older adult;opioid overdose;Outcome;Patient-Focused Outcomes;Patients;Persons;Population;population health;Post-Traumatic Stress Disorders;predictive modeling;Predisposition;prevent;Primary Care;Process;Public Policy;Race;racial minority;Regression Analysis;Reporting;Research;Research Personnel;Resources;Retrieval;Risk;Risk Reduction;Secure;sex;Signs and Symptoms;Smoking;social;social health determinants;Social isolation;Social Work;Stress;Structure;structured data;substance use;System;Time;Traumatic Brain Injury;United States Department of Veterans Affairs;Update;Veterans;Veterans Health Administration;virtual;Vulnerable Populations;Woman;Work

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Clinical Research;Genetics;Human Genome;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BOSTON

PHR: Project Narrative The vaginal microbiome is linked to important health conditions including bacterial vaginosis (BV), preterm birth, HIV, and cervical cancer, but reasons for these links are unclear and current BV-directed therapies do not work well. We will study how metabolites in vaginal fluid, including the potentially harmful molecules putrescine and imidazole propionate, are produced by the microbiome, how they cause inflammation in the vagina, and whether they can be blocked by pharmacological agents. The results will provide important new knowledge about causes of BV and vaginal diseases and will help to find new therapies for preventing and treating these diseases in women globally.

PI_NAMEs: BLOOM, SETH MICHAEL (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Address;Affect;Africa South of the Sahara;African;African Women;Amines;Anabolism;Anatomy;Bacteria;bacterial community;Bacterial Physiology;Bacterial Vaginosis;Bacteriology;Biochemical;Biogenic Amines;Bioinformatics;Biological Markers;Biology;Cadaverine;candidate identification;candidate marker;career;career development;Cell Proliferation;Cellular Metabolic Process;Chemicals;Chemistry;Clinical;Clinical Markers;cohort;Collaborations;Communicable Diseases;Communities;cytokine;Data;Development Plans;diagnostic criteria;Disease;Disproportionately impacts women;eIF-5A;Environment;Enzymatic Biochemistry;enzyme activity;Enzyme Inhibitor Drugs;Enzymes;experience;experimental study;Functional disorder;General Hospitals;Genomics;Goals;Health;high volume manufacturing;HIV;HIV risk;Imidazole;Immune response;Immunologics;Immunology;immunoregulation;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;innovation;instructor;interest;Knowledge;Lactobacillus;Link;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Massachusetts;Measures;Mediating;Mediator;medical schools;Medicine;Mentors;Metabolic;metabolome;metabolomics;metagenome;Metagenomics;metatranscriptomics;Methods;microbial;Microbial Biofilms;microbiome;microbiome composition;microbiota;Mucositis;Mucous Membrane;multiple omics;novel;novel therapeutic intervention;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;pharmacologic;Physicians;Population;potential biomarker;Premature Birth;Prevalence;prevent;Production;Propionates;Putrescine;Reproducibility;reproductive outcome;reproductive tract;Research;Research Personnel;Role;Scientist;Site;skills;Smell Perception;Source;South African;Symptoms;targeted treatment;Testing;Therapeutic;Tissues;Training;translation factor;Universities;Vagina;Vaginal Diseases;vaginal fluid;vaginal microbiome;vaginal microbiota;Validation;Woman

PROJECT_TITLE: Mechanistic characterization of vaginal microbiome-metabolome associations and metabolite-mediated host inflammation

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Bioengineering;Genetics;Neurosciences

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project narrative The olfactory cortex plays key roles in odor processing, perception and memory, but the molecular mechanisms underlying olfactory cortex cell type specification remain unknown. Here, we propose to determine the gene expression and chromatin accessibility states of piriform cortex neurons in the adult mouse, and to characterize the dynamic interaction of regulatory chromatin and transcription factor activity that drive cell lineage specification during development. Our central hypothesis is that olfactory cortex cell types and their functional properties are specified by olfactory cortex-specific gene regulatory network mechanisms.

PI_NAMEs: FLEISCHMANN, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Acceleration;Adult;Area;ATAC-seq;Atlases;Bayesian Analysis;Brain;Cell Lineage;cell type;Cells;Chromatin;Communities;comparative;Complement;Computational Molecular Biology;Computer Models;computer science;Coupled;Data;Data Set;Development;Differential Equation;Disease;dynamic system;Epigenetic Process;experimental study;Gene Expression;gene regulatory network;gene repression;Genetic;Goals;Health;Histologic;insight;Knowledge;Link;Measures;Memory;Modeling;Molecular;Molecular Computers;Molecular Profiling;Motor;motor control;Mus;Neocortex;neocortical;network models;Neuronal Differentiation;Neurons;Neurosciences;novel;Odors;olfactory bulb;Olfactory Cortex;Olfactory Pathways;Perception;piriform cortex;Play;Positioning Attribute;programs;Property;Publishing;Repression;Resolution;Reverse engineering;Role;Sensory;single cell sequencing;single-cell RNA sequencing;Smell Perception;Somatosensory Cortex;Specific qualifier value;System;Systems Biology;Systems Theory;Technology;Testing;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: Gene regulatory network control of olfactory cortex cell type specification

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The majority of prostate cancer mortality is due to failure of endocrine therapies to maintain suppression of androgen receptor activity. The proposed studies are focused on understanding how genome structural alterations in prostate cancer cells promote persistent androgen receptor activity during endocrine therapy. This project will study and model these genome structural alterations to understand their role in supporting endocrine therapy resistance, and develop new therapeutics that eliminate tumor cells harboring these alterations.

PI_NAMEs: DEHM, SCOTT M. (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: abiraterone;Acceleration;Acetates;Address;Affinity;androgen independent prostate cancer;Androgen Receptor;Androgen Suppression;Androgens;antagonist;anti-cancer research;AR gene;Architecture;Binding;Biological;Biological Markers;Cancer Patient;Cells;Cessation of life;clinically relevant;combat;Complex;Computing Methodologies;curative treatments;Data;Diagnosis;Disease;DNA sequencing;Endocrine;enzalutamide;Exons;Failure;Feedback;Frequencies;Future;Gene Rearrangement;Generations;Genetic Transcription;Genetically Engineered Mouse;Genome;Genome Mappings;Genotype;Goals;Gonadotropin-Releasing Hormone Analog;Growth;Heterogeneity;Homeostasis;hormone therapy;improved;In Vitro;in vivo;Knock-out;Knowledge;Length;Ligand Binding Domain;male;Malignant neoplasm of prostate;Malignant Neoplasms;Medicine;Metastatic Prostate Cancer;Modeling;Molecular;Molecular Target;mortality;mouse model;Mus;neoplastic cell;new therapeutic target;Nobel Prize;novel therapeutics;Operative Surgical Procedures;Optics;Outcome;Output;Pathway interactions;patient derived xenograft model;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Physiology;PI3K/AKT;pressure;Production;programs;Proliferating;Prostate;prostate cancer cell;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;Protein Analysis;protein function;PTEN gene;Quality of life;Radiation therapy;receptor expression;Receptor Signaling;Recurrence;Recurrent tumor;Regulation;Repression;Resistance;resistance mechanism;response;Role;screening;Specimen;standard of care;Stanolone;steroid hormone;Structure;targeted treatment;Techniques;Testing;Testosterone;Therapeutic;therapeutic development;therapy resistant;Tissues;transcription factor;transcriptome sequencing;tumor;Tumor Suppressor Genes;Variant;Whole Organism;Work

PROJECT_TITLE: AR Gene Rearrangements and AR Signaling in Prostate Cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]