ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Dual Eligible Special Needs Plans (D-SNPs) have emerged as the largest category of managed care plans intended to integrate Medicare and Medicaid coverage for the nation’s 12.2 million dual eligibles and have evolved to attain different levels of integration. This project will use national Medicare and Medicaid administrative data, nursing facility assessment data, and patient experience surveys to identify attributes of D- SNPs and state Medicaid policies associated with higher quality, efficient, and equitable care, and it will use a difference-in-differences design to identify effects of integrating coverage, leveraging variation in default enrollment into integrated plans. Findings from this project will provide evidence to guide how policymakers improve D-SNPs to address the health care needs of their medically and socially vulnerable enrollees.

PI_NAMEs: MEYERS, DAVID JOSEPH;ROBERTS, ERIC T (contact)

PROGRAM_OFFICER_NAME: KARACA, ZEYNAL

PROJECT_TITLE: Integrating Medicare and Medicaid coverage in managed care: effects on quality, utilization, and disparities

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Radiation Oncology

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: In this K12 proposal we wish to establish a training and mentoring program for junior faculty in oncology specialties including hematology-medical oncology, radiation, surgical, gynecologic, neurosurgical and urologic oncology that will provide comprehensive education, training and mentoring for scholars interested in a clinical research career. We will expand existing programs at the Laura and Isaac Perlmutter Cancer Center (PCC) and leverage ongoing training efforts within the NYU Clinical and Translational Science Institute (CTSI) to create an integrated, full-thickness training, mentoring and follow-up program. Our long-term objective is to recruit the next class of scholars in oncology clinical research that will launch careers in clinical investigation and promote their ability to assume leadership roles at PCC and elsewhere.

PI_NAMEs: SULMAN, ERIK  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;anti-cancer research;Cancer Patient;career;career development;Clinical;Clinical Oncology;Clinical Research;Clinical Sciences;clinical training;Clinical Trials;cohort;Collaborations;Computational Biology;Creativeness;Dedications;Development;Educational Status;Ensure;expectation;experience;Exposure to;Faculty;Fostering;Grant;Individual;Informatics;Infrastructure;innovation;Institution;Instruction;Investments;Malignant Neoplasms;Manuscripts;Medical Oncologist;Mentored Clinical Scientist Development Program;Mentors;multidisciplinary;next generation;Performance;Preparation;preservation;Productivity;programs;Publications;Radiation Oncologist;Research;research and development;Research Personnel;Research Project Grants;Resources;responsible research conduct;Science;skill acquisition;skills;success;Surgical Oncologist;Time;Training;translational impact;translational oncology;Translational Research;Work;Writing

PROJECT_TITLE: K12 Training for Clinical and Translational Oncology Researchers

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: CANCER RESEARCH EDUCATION PROGRAM: NARRATIVE It is fundamental to establish a sustainable infrastructure that will facilitate the training and inclusion of more underrepresented minority faculty researchers and students in cancer health disparities research. Virginia State University (VSU) and Virginia Commonwealth University (VCU) Massey Cancer Center (MCC) have established a collaborative Cancer Research Education Program (VSU-MCC CREP) to maximize existing institutional resources and to build an infrastructure that will increase the capacity of faculty and students to pursue and facilitate cancer health disparities research and enhance VSU’s ability to lead in education, community engagement, and research in cancer health disparities in Virginia.

PI_NAMEs: MOSAVEL, MAGHBOEBA  (contact)

PROJECT_TERMS: Address;Advocate;anti-cancer research;Applications Grants;Area;Award;Cancer Center;cancer health disparity;Capital;career;Catchment Area;Collaborations;Communities;community engaged research;community engagement;Complex;course sequence;Data;Death Rate;design;Development;Disadvantaged;Discipline;Disparity;Diverse Workforce;Education;Education and Outreach;education research;experience;Faculty;Foundations;Funding;Future;Goals;Grant;Health Disparities Research;health disparity;health inequalities;Historically Black Colleges and Universities;improved;Incidence;Infrastructure;innovation;Institution;Institutionalization;interdisciplinary approach;interest;K-Series Research Career Programs;Knowledge;Lead;Localized Malignant Neoplasm;Malignant Neoplasms;Manuscripts;Mentors;Minority;minority investigator;minority student;Mission;multidisciplinary;NCI Center for Cancer Research;outreach;Pilot Projects;pilot test;Policies;programs;Research;Research Personnel;Research Project Grants;Research Training;Resources;Secure;Series;skills;Solid;Students;summer research;Training;Training and Education;Training Programs;training project;Translations;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;university student;Virginia;Work;Writing

PROJECT_TITLE: SUCCEED Cancer Research Education Program (CREP)


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: MEZA, RAFAEL  (contact)

PROJECT_TERMS: Address;Affect;Age;Alaska Native;American Indian Population;American Indians;Attention;Behavior;Black race;Cigar;Cigar Smoking;Cigarette;cigarette smoking;Collaborations;college;Consultations;Data;Data Analyses;data modeling;Disparate;Education;Educational Status;Electronic Nicotine Delivery Systems;ethnic minority;Ethnic Origin;Ethnic Population;Foundations;Future;Health;health disparity;high school;high school degree;higher education;Hispanic;Hispanic Populations;Individual;Menthol;Modeling;models and simulation;Monitor;mortality;National Health Interview Survey;Nicotine;Not Hispanic or Latino;Outcome;Pattern;Policies;Policy Analysis;Policy Maker;polytobacco use;Population;Population Assessment of Tobacco and Health;population survey;Prevalence;Public Health;Quasi-experiment;Race;racial disparity;racial minority;racial population;Regulation;Relapse;Research;sex;smoking initiation;smoking prevalence;Socioeconomic Status;socioeconomics;Subgroup;Surveys;systematic review;Tobacco;tobacco flavor;tobacco products;tobacco regulation;Tobacco use;United States Food and Drug Administration;Update;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Modeling the Impact of Tobacco Use and Regulations on Vulnerable Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-R]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Emergency Care;Health Services

ORG_CITY: AUSTIN

ORG_NAME: BRIDGESOURCE MEDICAL CORPORATION

ORG_STATE: TX

PHR: Project Narrative In the US, patients presenting to the Emergency Department with an unknown Cardiac Implanted Electronic Device represent a unique problem. Often correct treatment requires the reprogramming of the device by the manufacturer, but it is impossible to quickly determine the manufacturer of each device in the Emergency Department. The MDI a portable, hand-held device that can identify Cardiac Implanted Electronic Devices from any manufacturer either in the Emergency Department, or in transit to the Emergency Department, eliminating the need for a time-consuming and unnecessary x-ray, and enabling first-line medical personnel. The proposed device identifier works by mimicking the “wakeup call” communication of the five major CIED programmers in sequence, and would identify each device by analyzing the response from the CIED.

PI_NAMEs: WALMSLEY, JOHN  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accident and Emergency department;Acute;Age;American;Award;Cardiac;cardiac device;cardiac implant;Cardiovascular system;Caring;Certification;Clinical;clinical practice;commercialization;Communication;Computers;Consult;Consumption;Custom;Databases;design;design verification;Development;Devices;Diagnostic;Electronics;Electrophysiology (science);Emergency Department Physician;Emergency Medicine;Emergency Situation;Engineering;experience;Funding;Grant;handheld equipment;Health;Health Personnel;Hospital Personnel;Hospitals;Human;Human Resources;Implant;Implantable Defibrillators;implantation;improved;innovation;Label;Lead;Length of Stay;Magnetism;manufacture;Manufacturer;manufacturing process;Marketing;Medical;Medical Device;Modeling;mortality;Ohio;older patient;operation;Pacemakers;Patient risk;Patients;Phase;portability;Principal Investigator;Process;Production;programs;Radio-Opaque;Resort;response;Roentgen Rays;rural area;Saint Jude Children's Research Hospital;Sales;Shapes;Small Business Innovation Research Grant;Software Validation;Techniques;Thoracic Radiography;Time;Triage;Validation;validation studies;wasting;Work

PROJECT_TITLE: Medical Device Identifier to Improve Emergency Triage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-W(90)B]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE The renewal of the University of Kentucky Markey Cancer Center’s Appalachian Career Training In ONcology (ACTION) Program will continue a culturally centered cancer education and training opportunity for students from rural, disease-burdened, low socioeconomic, and low education-attainment Appalachian Kentucky communities. The program will enhance the diversity of the biomedical workforce by preparing underrepresented Appalachian Kentucky high school and undergraduate students for biomedical careers. ACTION will also increase the community’s understanding of cancer, thereby addressing the cancer and education disparities in Appalachian Kentucky and beyond.

PI_NAMEs: VANDERFORD, NATHAN LANE (contact)

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Academic achievement;Achievement;Address;anti-cancer research;Appalachian Region;Area;Bachelor's Degree;burden of illness;Cancer Burden;cancer care;Cancer Center;cancer education;cancer health disparity;Cancer Research Project;career;career development;career preparation;Caregivers;Clinical;clinical care;Communities;Community Outreach;Complement;Country;County;COVID-19 pandemic;curriculum development;Death Rate;Degree Completion;Degree program;Disparity;Doctor's Degree;Early Intervention;economic disparity;economic indicator;Education;Education and Outreach;education research;Educational Activities;Educational Curriculum;Educational Intervention;Educational workshop;experience;Faculty;faculty mentor;Family;Female;Funding;Goals;hands on research;Health;Health behavior;health inequalities;Healthcare;high school;high school degree;High School Student;higher education;Home;Incidence;Income;Individual;Institution;Intervention;Kentucky;Knowledge;Link;Malignant Neoplasms;matriculation;medically underserved;member;Mentors;Mentorship;Middle School Student;National Cancer Institute;Oncology;oncology program;outreach;outreach program;Parents;peer;peer coaching;peer networks;Population;Poverty Areas;Preparation;programs;Readiness;Research;Research Activity;Research Training;Rest;Rural;Rural Appalachia;Science;science education;skills;social;social health determinants;socioeconomics;Students;Target Populations;teacher;Training;Training and Education;training opportunity;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;Universities;virtual;Youth

PROJECT_TITLE: Appalachian Career Training in Oncology (ACTION) Program


PI_NAMEs: MENDEZ EMILIEN, DAVID  (contact)

PROJECT_TERMS: Advisory Committees;Agreement;Area;Behavior;Behavioral;Collaborations;Communication;Data Analyses;data modeling;data sharing;Evaluation;Feedback;Fostering;Health;Individual;Leadership;Logistics;Measures;meetings;Modeling;Monitor;Policies;Population;Procedures;Publications;Regulation;Research;Research Personnel;Research Project Grants;response;Schedule;Science;synergism;Tobacco;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco Surveillance;Tobacco use;United States Food and Drug Administration;Writing

PROJECT_TITLE: Admin Core


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Narrative We have identified a subgroup of colorectal cancer (CRC) patients as having “Outlier Methylation Phenotype” (OMP) using normal tissue methylome and OMPs are significantly associated with CRC patients over healthy controls and African American CRC patients are more than twice as likely to have OMP than Caucasians. In our current grant application, we propose to develop OMP as a less- invasive CRC screening and prognostic tool by evaluating the consistency of OMP status in a less-invasive (whole blood) tissue with an invasive tissue (normal colorectal mucosa). We will test whether OMPs identified in colorectal tissues can also be identified in whole blood samples using epigenome-wide data from >850K CpGs and analyze the association of OMP in CRC patients with known CRC molecular subtypes and with future clinical outcomes in controls; and study the association of genetic (single nucleotide polymorphisms including ancestry informative markers) and environmental (diet and social determinants of health) factors with OMPs.

PI_NAMEs: GHOSH, JAYASHRI  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: adenoma;Affect;African;African American;African American population;Age;anti-cancer research;Applications Grants;Biopsy;Black race;Blood;Blood specimen;BRAF gene;Cancer Detection;cancer health disparity;Cancer Patient;cancer type;caucasian American;Caucasians;Clinical;Coin;Colon;colon cancer family registry;colon cancer patients;Colonoscopy;Colorectal;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;Communities;comparative;CpG Island Methylator Phenotype;CpG Islands;Data;Death Rate;Development;Diagnosis;Diagnostic;Diet;dietary;DNA;DNA Markers;DNA Methylation;early detection biomarkers;Early identification;Endoscopy;Environmental Risk Factor;Epigenetic Process;epigenome;Fecal occult blood;follow-up;Frequencies;Future;Gastroenterology;Gene Expression;Genes;Genetic;genetic variant;Genotype;Germ Lines;Goals;Health;high risk population;Incidence;Individual;KRAS2 gene;Location;Malignant Neoplasms;Methylation;methylation biomarker;methylation pattern;methylome;MLH1 gene;molecular marker;molecular subtypes;mortality;Mucous Membrane;Mutation;Normal tissue morphology;Outcome;patient population;patient subsets;Patients;peripheral blood;Phenotype;Polyps;Prevention;Procedures;prognostic;prognostic tool;Questionnaires;Race;racial disparity;Recording of previous events;recruit;Research;research study;response;Risk;risk prediction;Sampling;screening;Screening for cancer;Screening procedure;sex;Single Nucleotide Polymorphism;social health determinants;Subgroup;Surrogate Markers;Testing;The Cancer Genome Atlas;Tissues;tool;Treatment Protocols;treatment response;tumor;Tumor Tissue;University Hospitals;Variant;Whole Blood

PROJECT_TITLE: Development of blood-based methylation biomarkers for CRC risk prediction

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Despite the scaling up of evidence-based interventions to End the HIV Epidemic (EHE) in the U.S., several communities most affected by HIV – including Black/African American (AA) communities – lag behind the EHE goal of reducing HIV Infections by 90% by 2030. The proposed study aims to characterize ART adherence trajectories among AA people with HIV (PWH), and to examine the influence of psychosocial determinants of health on ART adherence and healthcare utilization. Understanding the influence of psychosocial determinants of health on ART adherence and healthcare utilization will aid in 1) identifying individuals most likely to benefit from the scaling out of evidence-based interventions, and 2) adapting interventions to better target modifiable determinants of ART adherence, which ultimately will support the health and longevity of AA PWH.

PI_NAMEs: SERRANO, VANESSA BIANCA (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;adherence rate;Adult;Affect;African American;African American population;Anti-Retroviral Agents;antiretroviral therapy;Behavioral Medicine;Black Populations;Black race;California;Caring;Characteristics;Classification;cohesion;Communities;Community Healthcare;Continuity of Patient Care;Data;Dedications;Descriptor;Development;Disease Outcome;Epidemic;Evidence based intervention;experience;Face;Fellowship;follow-up;Goals;Health;health care availability;health care service utilization;health determinants;health disparity;health management;health related quality of life;HIV;HIV diagnosis;HIV Infections;HIV Seropositivity;HIV/AIDS;improved;Individual;Intervention;Longevity;Medical;medication compliance;Mental Health;Outcome;Pattern;Persons;physical conditioning;poor health outcome;Population;Population Heterogeneity;psychosocial;Psychosocial Influences;psychosocial resources;Public Health;Qualitative Research;regional difference;Reporting;Research;Research Methodology;Research Personnel;resilience;Risk;Role;scale up;Self Efficacy;Severity of illness;social determinants;social stigma;Social support;Strategic Planning;Subgroup;Text Messaging;text messaging intervention;therapy adherence;Time;two way texting;United States;Viral;Viral Load result

PROJECT_TITLE: Examining Social Determinants of Antiretroviral Adherence Trajectories among African American Adults with HIV


PI_NAMEs: MISTRY, RITESH I (contact)

PROJECT_TERMS: Address;Advisory Committees;Applications Grants;Area;authority;Award;Behavioral;career;career development;career networking;Collaborations;Communication;Computer Models;Data;Data Analyses;data modeling;design;Development Plans;Education;Educational Activities;ethnic disparity;Evaluation;Event;experience;Feedback;Funding;Goals;Grant;Health;improved;Individual;interest;K-Series Research Career Programs;Knowledge;Leadership;Learning;Mentors;Mentorship;models and simulation;Nicotine;online course;Participant;Peer Review;Persons;Pilot Projects;Policy Analysis;Positioning Attribute;Principal Investigator;Productivity;programs;Publications;racial disparity;Reaction;Reporting;Research;Research Personnel;Research Project Grants;Resources;Role;Science;Scientist;simulation;skills;socioeconomic disparity;symposium;Tobacco;tobacco control;tobacco regulation;tobacco regulatory science;Training;training opportunity;United States National Institutes of Health;webinar;Work;Writing

PROJECT_TITLE: Career Enhancement Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: RELEVANCE TO PUBLIC HEALTH Physician scientists bring unique skills to scientific investigation and offer enhanced opportunities to translate basic scientific discovery to diagnosis and treatment of human disease. This program seeks to meet the need for more neurologists, neurosurgeons and pathologists trained in basic neuroscience.

PI_NAMEs: RICHERSON, GEORGE B (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: accurate diagnostics;Affect;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Award;Basic Science;Benchmarking;Brain Diseases;career;Career Choice;career development;catalyst;Clinical;clinical application;clinical care;Clinical Research;clinical training;college;Complex;cost;Dedications;design;Diagnosis;diagnostic tool;Disease;Doctor of Philosophy;Epilepsy;Ethics;Faculty;Failure;Family;Fellowship;Fellowship Program;Funding;Funding Opportunities;Glioma;Goals;Grant;Human;human disease;innovation;Institution;Interview;Investigation;Iowa;K-Series Research Career Programs;Knowledge;Light;Medicine;member;Mentors;Mentorship;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurologic;Neurologist;Neurology;neuropathology;Neurosciences;Neurosurgeon;neurosurgery;novel strategies;Parkinson Disease;Participant;Pathologist;Pathology;Pathway interactions;Patients;Physicians;Positioning Attribute;Productivity;programs;Public Health;Publishing;Qualifying;recruit;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Residencies;Resources;responsible research conduct;Science;Scientist;skills;Societies;Statistical Methods;Stroke;Time;Training;Training Programs;Translating;Translational Research;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Carver College of Medicine Clinical Neuroscientist Training Program (CNS-TP)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

ORG_CITY: DURHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Relevance statement: Development of shock marks a critical event in sepsis and is linked to a dramatic increase in morbidity and mortality. Our preliminary data supports that mast cells, which are best known for their ability to launch powerful inflammatory responses in allergy, are shaping key features of vascular pathology in septic shock. By defining platelets as the circulating source of mast cell activation and by examining the relevance of mast cell activation in septic patients, we will develop a comprehensive picture of the events that shape development of shock in sepsis.

PI_NAMEs: ABRAHAM, SOMAN N (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Adhesions;Anaphylaxis;Animals;Behavior;biobank;Biological;Biological Assay;Biological Markers;Biology;Blood capillaries;Blood Cells;Blood flow;Blood Platelets;Blood Pressure;Blood Pressure Monitors;Blood Vessels;Cardiac Surgery procedures;Cell Communication;Cell Degranulation;Cell Shape;Cessation of life;Chymase;Classification;Clinical;clinically relevant;cohort;Complex;Data;Death Rate;density;Deterioration;Development;Diameter;Disease;Disease Progression;Drops;Edema;Effector Cell;endothelial dysfunction;Endothelium;Event;Extravasation;Gene Expression Profiling;Goals;Hemostatic Agents;Hemostatic function;Histamine;Hypersensitivity;Hypotension;Hypoxia;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Knock-out;Knockout Mice;Link;lipid mediator;mast cell;Measures;Mediating;Mediator;Medical emergency;Microcirculatory Bed;Modeling;Molecular;Morbidity - disease rate;mortality;Mortality Determinants;Multiple Organ Failure;novel;novel therapeutic intervention;Outcome;Oxygen;Pathology;Pathway interactions;Perfusion;Phenotype;photoacoustic imaging;Plasma;Platelet Activating Factor;Platelet Activation;Platelet aggregation;prevent;Receptor Protein-Tyrosine Kinases;Records;Reporting;Resistance;response;Role;Sampling;Sepsis;septic patients;Septic Shock;Shapes;Shock;Side;Signal Pathway;Signal Transduction;Source;Syndrome;systemic inflammatory response;Technology;Testing;TIE-2 Receptor;Tissues;tool;Tryptase;Tyrosine Kinase Inhibitor;Vascular Permeabilities;Vasomotor;Viral Hemorrhagic Fevers;Virus;Whole Blood;Wild Type Mouse;Work

PROJECT_TITLE: Platelet- mast cell interactions as determinants of the vascular pathology in septic shock.


PI_NAMEs: JEON, JIHYOUN  (contact)

PROJECT_TERMS: Age;age difference;age related;behavioral health;Behavioral Risk Factor Surveillance System;Birth;Cancer Intervention and Surveillance Modeling Network;Cardiovascular Diseases;career;Cessation of life;Chronic Obstructive Pulmonary Disease;Cigarette;cohort;Collaborations;Communities;computer code;Computer Models;Computer software;computerized data processing;Consultations;Data;Data Analyses;Data Collection;data dissemination;data modeling;data repository;Data Set;Death Rate;design;Disease;Drug usage;Ensure;Ethnic Origin;evidence base;Frequencies;Future;Gender;Goals;Health;high standard;indexing;Infrastructure;Link;longitudinal analysis;Longitudinal cohort;machine learning method;Malignant neoplasm of lung;Mathematics;Measures;Methods;Modeling;Monitor;mortality;National Health Interview Survey;Nicotine;Outcome;Parameter Estimation;Pattern;Pilot Projects;Policy Analysis;polytobacco;Population Assessment of Tobacco and Health;population survey;Prevalence;Protocols documentation;Public Health;Race;Relapse;repository;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Resources;Sales;Science;Services;Smokeless Tobacco;sociodemographic factors;Socioeconomic Status;software development;statistical and machine learning;Statistical Models;statistics;Surveys;Tobacco;tobacco control;tobacco products;tobacco regulation;Tobacco use;tool;United States Food and Drug Administration;web site;Youth

PROJECT_TITLE: Data Analysis and Modeling Core (DAM)


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_DEPT: CHEMISTRY

ORG_NAME: HUNTER COLLEGE

PHR: Narrative The study of complex traits is fundamental to understanding the nature and behavior of living systems. Most diseases, like Alzheimer or cancer have complex traits whose genetic characterization in model systems have been essential to finding effective therapies. Similarly, venom is a complex trait that has evolved throughout the tree of life, and studying its evolution has broad applications to understanding the development of homologous tissues, the origins of novel genes, and the molecular mechanisms behind the regulation and expression of bioactive compounds.

PI_NAMEs: HOLFORD, MANDE N. (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Alzheimer's Disease;Analgesics;Animals;Behavior;Biodiversity;Biological;Biological Models;biological research;Biology;Breeding;Cellular biology;Cephalopoda;comparative;Complex;Development;Diabetes Mellitus;Disease;Disparate;drug development;drug discovery;effective therapy;Evolution;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Engineering;genetic manipulation;Genomics;Gland;gland development;Health;Heart Diseases;high reward;high risk;Human;in vivo;Industry;Life;Maintenance;Malignant Neoplasms;Marine Invertebrates;Medicine;Mission;Modeling;Molecular;Molecular Biology;Nature;novel;Organism;Pain;Pathway interactions;Peptides;Phenotype;precision medicine;Prevalence;Production;programs;Proteins;Proteomics;prototype;receptor;Regulation;Research;Research Personnel;response;Salivary Glands;success;Surface;System;Therapeutic;Tissues;tool;Toxin;trait;transcriptomics;Transgenic Model;Transgenic Organisms;Trees;tumor;United States National Institutes of Health;Venoms;Work

PROJECT_TITLE: Charting the evolutionary development of novel genes and the molecular mechanisms of gland tissue organizationin cephalopods


PI_NAMEs: LIBER, ALEX CRAIG (contact)

PROJECT_TERMS: Behavior;Case Study;Communities;comparative;Data;Decision Making;Development;Epidemiology;Health;Health behavior and outcomes;Health Benefit;In Vitro;interest;Investments;Knowledge;knowledge base;Language;Marketing;Modeling;models and simulation;novel;Outcome;Persons;Policies;Policy Analysis;Policy Maker;Policy Making;population health;Population Study;Process;Production;Public Health;Published Comment;Regulation;Research;research data dissemination;Research Personnel;Research Project Grants;Research Support;response;Science;simulation;Source;Structure;systematic review;Tobacco;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;tool;Translations;Work

PROJECT_TITLE: Policy Analysis and Dissemination Core (PAD)


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Heart disease is the leading cause of death in the US (even in 2020), while the Center for Disease Control estimates that 6.1 million suffer from abnormal heart rhythms. Adenylyl cyclase produces the small molecule cyclic AMP that is a crucial regulator of cardiac function, including heart rate, in addition to many additional physiological processes. Our studies provide a better understanding of the mechanisms that regulate the local production of cyclic AMP and ultimately heart rate and will uncover new strategies for therapeutic interventions.

PI_NAMEs: DESSAUER, CARMEN W. (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: A kinase anchoring protein;Address;Adenylate Cyclase;Adrenergic beta-Antagonists;Agonist;Anxiety;Asthma;Automobile Driving;Behavior;biological systems;Body System;Cardiac;Cardiac Myocytes;career;Cause of Death;cell growth regulation;Centers for Disease Control and Prevention (U.S.);Clinical;Complex;Cyclic AMP;Drug Addiction;Drug Targeting;drug withdrawal;Environment;Enzymes;Event;functional outcomes;Funding;G-Protein-Coupled Receptors;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Proteins;Heart Abnormalities;Heart Diseases;heart function;Heart Rate;heart rhythm;Immune response;interest;Learning;Macromolecular Complexes;Memory;Modification;Motor;Names;National Institute of General Medical Sciences;Nature;novel;novel therapeutic intervention;Opioid;Pain;Physiological;Physiological Processes;Process;Production;Property;Proteins;Regulation;Renal function;Research;response;scaffold;Signal Pathway;Signal Transduction;Site;small molecule;Specificity;Stress;System;Therapeutic Intervention;Tissues;tool;transmission process

PROJECT_TITLE: Regulation of Adenylyl Cyclase Signaling Pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Strategies to safely and effectively prevent ovarian cancer can have important public health impact since ovarian cancer causes more deaths than any other diseases of the female reproductive system. New scientific evidence shows that most ovarian cancers originate from the fallopian tubes rather than from the ovaries, and therefore removing fallopian tubes can effectively reduce ovarian cancer risk while allowing patients to preserve the ovaries that are beneficial for cardiovascular, bone, and cognitive health. The proposed project seeks to identify physician- and patient-related factors that influence the adoption of this new approach to ovarian cancer prevention and inform ways to improve utilization and informed decision-making.

PI_NAMEs: XU, XIAO  (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Salpingectomy for Ovarian Cancer Risk Reduction: Improving Utilization and Informed Decision-Making

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Project Narrative The mechanistic basis of many biological processes, such as development, aging, homeostasis, and response to stimuli can be revealed from understanding of metabolism, and there is an urgent need for the imaging platform to visualize 3D volumetric metabolic dynamics and heterogeneity in live cells and tissues. Our proposed study is to develop and optimize a state-of-the-art 3D imaging platform that combining a new generation of deuterated glucose- probed stimulated Raman scattering microscopy with upgraded tissue clearing recipes and custom designed spectral linear unmixing algorithm, for visualizing large volumetric distribution of more than 20 newly synthesized molecules in animal models for studying metabolic pathways.

PI_NAMEs: SHI, LINGYAN  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Adipose tissue;Aging;Algorithm Design;Algorithmic Analysis;algorithmic methodologies;Algorithms;Animal Model;Animals;Biological Process;Biomass;Brain;Carbohydrates;Carbon;Cells;chemical bond;Chemicals;Computational algorithm;Computing Methodologies;computing resources;Custom;Data;Data Analyses;Data Set;design;Deuterium;Development;DNA;Fingerprint;Generations;Genetic;Glucose;glucose metabolism;Glycogen;Goals;Heterogeneity;Homeostasis;Human;Image;imaging platform;imaging probe;Imaging Techniques;In Situ;in vivo;innovation;Label;Life;Lipids;Liver;macromolecule;Measures;Metabolic;metabolic abnormality assessment;metabolic imaging;Metabolic Pathway;Metabolism;Methods;Microscopy;Molecular;multiplexed imaging;Mus;Nutrient;Optics;Organ;Pancreas;Pathway interactions;Pattern;Penetration;Play;Printing;Proteins;Protocols documentation;Publishing;Radiation;Recipe;Regression Analysis;Reporting;Resolution;Resources;response;RNA;Role;Signal Transduction;Source;Spatial Distribution;Stimulus;sugar;Techniques;Technology;Three-Dimensional Imaging;three-dimensional visualization;Time;Tissues;tool;Urea;Visualization

PROJECT_TITLE: Sugar Probed SRS Volumetric imaging of Metabolic Activities

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Diabetes;Nutrition;Obesity

ORG_CITY: STANFORD

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Obesity currently affects 42% of U.S. adults, costing 173 billion dollars in health care costs annually. Human genetics links obesity to defects in an organelle called the primary cilium, where G protein-coupled receptors (GPCRs) transmit extracellular information across the cell membrane to direct cell signaling events. This project will decipher how the primary cilium membrane controls GPCR activity and how it responds to dietary lipid consumption with the long-term goal of finding better strategies to treat metabolic disease.

PI_NAMEs: KINNEBREW, MAIA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Acceleration;Address;Adipocytes;Admission activity;Adult;Affect;Animals;Area;Automobile Driving;Award;Binding;Biochemical;Biochemistry;Biological;biological research;Biology;Biophysics;Brain;career;Cell membrane;Cell surface;Cells;Cellular biology;Cholesterol;Cilia;ciliopathy;Classification;Consumption;cost;Dedications;Defect;Development;Developmental Biology;Diabetes Mellitus;Diet;Dietary Fats;Doctor of Philosophy;Educational Status;Electron Spin Resonance Spectroscopy;Ensure;Environment;equipment acquisition;Event;experience;extracellular;Faculty;Faculty Workshop;Fatty Acids;Financial Support;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic;Genetic study;Goals;graduate school;Health;Health Care Costs;high school;Homeostasis;Human;Human Genetics;Human Resources;In Vitro;in vivo;Institution;instrument;insulin secretion;interest;Islet Cell;Islets of Langerhans;Laboratories;Lead;Leadership;Link;lipid biosynthesis;lipid transport;Lipids;Measures;medical schools;meetings;member;Membrane;Membrane Biology;Mentors;Mentorship;Metabolic Diseases;Metabolism;Methodology;minority student;Molecular;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organelles;Pathway interactions;peer;Perception;Persons;Play;Postdoctoral Fellow;Privatization;Process;programs;Property;Proteins;Reader;receptor;Receptor Signaling;Recording of previous events;recruit;Research;Research Personnel;Research Training;Resource Sharing;Role;Satiation;Series;Signal Transduction;skills;Spectrum Analysis;Stimulus;Structure;Students;success;symposium;Syndrome;System;Talents;Techniques;Testing;Time;tissue culture;tool;trafficking;Training;transmission process;undergraduate student;Universities;Vision;Visualization;Voting Right;Work

PROJECT_TITLE: Deciphering the lipid composition of primary cilia in human metabolic disease


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Digestive Diseases;Microbiome;Neurosciences;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Damaging more than just the skin, burn injuries can lead to excessive inflammation, often stemming from a breach in the intestinal epithelial barrier, which can allow translocation of bacteria and bacterial products into the circulation. Advanced age is an independent risk factor for mortality after burn injury, especially in patients with severe burns, and aged patients experience greater levels of neurological impairment after burn injury. By investigating age-related mechanisms responsible for early damage to the gut and blood brain barriers after burn injury, we hope to identify novel strategies to reduce the impact of this post-injury neuroinflammation and mental decline seen in elderly burn patients.

PI_NAMEs: WALRATH, TRAVIS MICHAEL (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Abbreviations;Age;age effect;age related;aged;Aging;aging population;Alkaline Phosphatase;Analysis of Variance;Apoptosis;Astrocytes;Bacteria;Bacterial Translocation;Biology;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier permeabilization;Body Surface Area;Body System;Brain;Brain region;Burn injury;Calcium Binding;CCL2 gene;CCR;Cell Death;Cell Proliferation;Cell Wall;chemokine;chemokine receptor;Circulation;Clinical;Clinical Research;clinically relevant;Colony-forming units;commensal bacteria;CREB1 gene;CXCL2 gene;Cyclic AMP-Responsive DNA-Binding Protein;cytokine;cytokine release syndrome;Data;Delirium;dentate gyrus;Development;Distant;Elderly;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;Exhibits;experience;experimental study;Exposure to;Fluorescein;Fluorescein-5-isothiocyanate;Functional disorder;G-Protein-Coupled Receptors;gastrointestinal epithelium;Glial Fibrillary Acidic Protein;Goals;gut bacteria;gut-brain axis;Hematoxylin and Eosin Staining Method;Hippocampus;ileum;Immunofluorescence Immunologic;Immunohistochemistry;Impaired cognition;Impairment;In Vitro;in vivo;Incidence;Inflammaging;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Inflammatory Response;injured;Injury;Integral Membrane Protein;Interleukin-1 beta;Interleukin-6;Interleukins;intestinal barrier;intestinal epithelium;intestinal fatty acid binding protein;Intestinal permeability;Intestines;intraperitoneal;ionization;Ischemic Bowel Disease;Isothiocyanates;Knock-out;Knockout Mice;Lead;Leaky Gut;Leucine-Rich Repeat;LGR5 gene;Ligands;Lipopolysaccharides;MAP Kinase Gene;Measures;Mediating;mental state;mesenteric lymph node;Microglia;Mitogen-Activated Protein Kinases;Molecular;mortality;mouse model;mRNA Expression;Mucous Membrane;Mus;Myosin Light Chain Kinase;Myosin Light Chains;Neurocognitive;neuroinflammation;Neurologic;novel;novel strategies;novel therapeutics;occludin;old mice;OLFM4 gene;Organ;Organoids;Outcome;Patients;Pattern;Permeability;Phosphorylation;Play;Production;Proliferating;Proteins;Psyche structure;Publishing;Risk Factors;Role;Sepsis;severe burns;Skin;Small Intestines;stem;stem cell biomarkers;stem cells;stemness;systemic inflammatory response;Testing;Tight Junctions;Time;tissue injury;tissue repair;Tissues;TNF gene;transcription factor;Trauma;Traumatic injury;Wild Type Mouse;Work

PROJECT_TITLE: Gut-brain axis at the intersection of aging and traumatic injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-B(20)L]


ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Principal Investigator: FM Fernández – Triboelectric Ambient Mass Spectrometry Imaging of Renal Cell Carcinomas  Mass spectrometry imaging (MSI) is a powerful tool used in cancer research to study biomarkers in tumors and to develop new cancer treatment drugs. Current MSI techniques are powerful but still suffer from some drawbacks such as not having sufficient sensitivity and not being able to ionize all compounds in a tissue sample. We propose a new generation of MSI technology that uses triboelectric nanogenerators coupled to laser ablation to improve on existing MSI techniques; this technology will have higher sensitivity and higher coverage than existing tools, improving our understanding of cancer biology.

PI_NAMEs: FERNANDEZ, FACUNDO MARTIN (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Ablation;Academia;Algorithms;anti-cancer research;Appearance;Area;Benchmarking;biobank;Biological;Biological Markers;biomarker discovery;Bladder;Cancer Biology;cancer cell;cancer imaging;cancer therapy;Characteristics;Charge;Chemicals;Clear cell renal cell carcinoma;Collaborations;Colon;Complex;Conventional (Clear Cell) Renal Cell Carcinoma;Coupled;Data;detection limit;Development;Devices;Diagnosis;Diagnostic;Disease;Early Diagnosis;electric field;Electrodes;Electrospray Ionization;Electrostatics;Environment;experimental study;Feces;Gases;Generations;Histologic;Image;imaging approach;Imaging Techniques;Imaging technology;improved;Industry;inflammatory marker;Inflammatory Response;instrument;Intervention;ion mobility;ion source;ionization;Ions;Isomerism;Kidney;kidney biopsy;Knowledge;Lasers;Lavage;lipid metabolism;lipid structure;lipidome;lipidomics;Lipids;Liquid Chromatography;Lung;Malignant Epithelial Cell;Malignant Neoplasms;mass spectrometer;mass spectrometric imaging;Measures;metabolic phenotype;Metabolism;metabolome;metabolomics;Microscope;Molecular;MRI Scans;Names;nano;nanoelectrospray;Neoplasm Metastasis;Noise;Ovarian;oxidized lipid;Pathway Analysis;Pathway interactions;Pattern;Performance;Pharmaceutical Preparations;Phase;Physical condensation;Physiologic pulse;pi bond;Play;Positioning Attribute;prevent;Principal Investigator;Process;Proteomics;Reaction;Renal Carcinoma;Renal Cell Carcinoma;Renal pelvis;Reproducibility;Research;Resolution;Role;Sampling;Signal Transduction;Source;Specificity;Spectrometry, Mass, Electrospray Ionization;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stream;Survival Rate;Symptoms;tandem mass spectrometry;Techniques;Technology;Testing;Thinness;Time;Tissue Sample;Tissues;tool;transcriptomics;tumor;tumor growth;tumor progression;Tumor Tissue;United States;Universities;urinary;Urine;Uterus;Vendor;voltage;Water;X-Ray Computed Tomography


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Intercellular adhesive junctions formed by cadherins are fundamental to development and organization of tissues in all multicellular animals, and their dysfunction in human disease has severe consequences including fatal developmental errors, cancer progression, and skin blistering. At these junctions, cadherin proteins assemble into intricate and highly ordered structures that bridge between the membranes of contacting cells. We propose to investigate the molecular mechanism of how these large and poorly understood superstructures form at critical cell-cell junctions and how they may be changed in disease by using a multi-pronged approach comprising structural, biophysical and functional methods, including direct visualization in cells and native tissues.

PI_NAMEs: BRASCH, JULIA  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Actins;Adherens Junction;adhesion receptor;Adhesives;Affinity;Animals;Architecture;Autoimmune Diseases;Binding;Biological Models;biophysical techniques;Biophysics;Bulla;Cadherins;Caenorhabditis elegans;Cell Separation;Cells;cost;Cryoelectron Microscopy;Cytoskeleton;Data;Desmosomes;Development;Disease;Drosophila genus;Endothelium;Environment;extracellular;Functional disorder;Genetic;Higher Order Chromatin Structure;Human;human disease;In Situ;Intercellular Junctions;Intermediate Filaments;Lateral;Link;Liposomes;Mechanical Stress;member;Membrane;membrane reconstitution;Methods;model organism;Molecular;Morphogenesis;mouse model;Mutagenesis;Mutation;Physiology;prevent;Property;Proteins;reconstitution;Resistance;Resolution;Skin;Solid;Specificity;Structure;System;Testing;Time;Tissues;Translating;tumor progression;Validation;Visualization;Whole Organism;X-Ray Crystallography

PROJECT_TITLE: Basis and Function of Lateral Assembly of Cadherin Molecules in Adhesive Junctions of Humans and Model Organisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Pain Research;Vulvodynia;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: ANELLEO, INC.

PHR: Narrative Vestibulodynia (VBD) is the most common cause of sexual pain and may last over 3 months at a time, compromising psychological functioning, interpersonal relations, and daily activities in women with VBD, indicating a desperate need for efficacious treatments. AnelleO has developed a unique flexible, mucoadhesive biodissolvable film for delivery of local anesthetic to the vestibule. The design of the film allows for easy self- administration of treatment, precise dosing, and blocks drug leakage which will increase patient compliance and satisfaction, offering the first vestibule-specific treatment for VBD.

PI_NAMEs: BENHABBOUR, SOUMYA RAHIMA;GELLER, ELIZABETH ;GUTHRIE, KATE M;JANUSZIEWICZ, RIMA  (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Address;Adhesions;Affect;aged;Anatomy;Anesthetics;Appearance;Area;Body Regions;Characteristics;Chronic;chronic painful condition;Client satisfaction;Clinical Research;Clothing;Coitus;cost;Cream;Data;design;Dimensions;Dose;Drug Delivery Systems;Dryness;effective therapy;efficacious treatment;Esthesia;Exercise;Extravasation;Film;flexibility;Future;Gel;hydroxyethylcellulose;Immunologics;In Vitro;Inflammatory Response;innovation;Interpersonal Relations;labia;Length;Lidocaine;Life;Local Anesthetics;Local Therapy;novel;Ointments;Operative Surgical Procedures;Pain;pain sensitivity;Patient Compliance;Patient Preferences;Penetration;Peripheral;Personal Satisfaction;Pharmaceutical Preparations;Positioning Attribute;pre-clinical;pre-Investigational New Drug meeting;preference;pressure;Process;psychologic;Public Health;Quality Control;Redness;reduce symptoms;Reporting;reproductive;Research;Running;Schedule;Self Administration;Sexual Health;Sexual Partners;Shapes;Site;Sting Injury;Surface;Surgical Management;surgical risk;Surveys;symptom management;System;Systems Development;Tampons;Texture;Therapeutic Agents;Thick;Thinness;Time;Tissues;Topical application;Touch sensation;treatment duration;United States;Vagina;Vestibular Nerve;Vestibule;Vestibulodynia;Vulva;vulvar pain;Width;Woman;Work

PROJECT_TITLE: Mucoadhesive film for the treatment of vestibulodynia


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Telehealth;Women's Health Research

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: In the eREACH study we will evaluate a theoretically and stake-holder informed eHealth delivery alternative to traditional genetic counseling, recruiting a nationally representative population of patients who are candidates for genetic testing for cancer susceptibility. We expect this research to significantly inform how best to deliver and communicate results of genetic testing in a way that provides access for all patients across the US, while maintaining adequate understanding and clinical use of genetic test results.

PI_NAMEs: BRADBURY, ANGELA R. (contact)

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Address;Affective;American Society of Clinical Oncology;Area;arm;Behavior;Behavioral;behavioral outcome;Cancer Advocacy;cancer care;cancer genetics;cancer predisposition;Clinical;clinical practice;clinically significant;Cognitive;Collaborations;Communication;Communities;Community Practice;Consolidated Framework for Implementation Research;Counseling;Data;design;Disclosure;Distress;Education;Effectiveness;effectiveness evaluation;effectiveness/implementation study;eHealth;Eligibility Determination;Evidence based practice;Family history of;Funding;Future;future implementation;Genetic;Genetic Carriers;Genetic Counseling;genetic counselor;Genetic Models;Genetic Services;genetic testing;Germ Lines;Health Services Accessibility;Hereditary Malignant Neoplasm;Hybrids;implementation barriers;improved;interest;Intervention;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;Medical Genetics;Methods;Modeling;National Health Interview Survey;novel;Oncology;Online Systems;Outcome;Participant;patient population;Patient Recruitments;Patient-Focused Outcomes;Patients;Pennsylvania;precision medicine;Predisposition;process evaluation;programs;Provider;provider communication;Randomized;Reaction;Recommendation;recruit;Reporting;Research;Risk;Risk Reduction;Sampling;screening;Screening for cancer;screening guidelines;Secure;Self Direction;Services;sociodemographic factors;Specialist;telegenetics;Telephone;Test Result;Testing;testing uptake;Time;treatment as usual;Uncertainty;United States National Institutes of Health;uptake;videoconference;Visit

PROJECT_TITLE: A Randomized Hybrid Type I effectiveness-implementation study of an Ehealth delivery Alternative for Cancer genetic testing for Hereditary cancer predisposition (eREACH)


PHR: Project Narrative The research in my lab is focused on development of mass spectrometry-based structural methods to study the higher order structure of proteins. We are particularly interested in studying protein structure in complex model systems that mimic the in vivo environment. We are developing these methods for discrete applications including protein aggregation and misfolding as well as further expanding them to other model systems.

PI_NAMEs: JONES, LISA M (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Affect;Affinity;Amino Acids;Animal Model;Binding;Biological Models;Caenorhabditis elegans;Cell Culture Techniques;Cells;Complex;Coupled;Crowding;design;Development;Diffusion;Environment;Higher Order Chromatin Structure;human disease;Hydroxyl Radical;In Vitro;in vivo;interest;Ligands;macromolecule;Mass Spectrum Analysis;method development;Methods;monolayer;novel therapeutics;oxidation;protein aggregation;Protein Conformation;protein folding;Protein Footprinting;protein function;protein misfolding;protein protein interaction;Protein Region;protein structure;Proteins;Research;Site;Solvents;System;three-dimensional modeling;Tissues

PROJECT_TITLE: Protein Footprinting Coupled to Mass Spectrometry for the Study of Protein Higher Order Structure in Complex Model Systems


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Detailed studies on the unique age-specific cellular and functional antibody profiles and the impact of pre- existing immunity on SARS-CoV-2 vaccine-specific responses are needed to maximize protective responses, durability, and inform potential future boosting strategies for young children. Our objective is to determine the impact of pre-existing immunity from either prior SARS-CoV-2 infection or the presence of passively-derived maternal antibodies on SARS-CoV-2 vaccine-specific immune responses to determine optimal timing of SARS- CoV-2 vaccines in early childhood.

PI_NAMEs: PRAHL, MARY  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: 2019-nCoV;4 year old;acute COVID-19;Adult;age group;Age Months;age related;aged;Antibodies;Antibody Repertoire;Antibody Response;antigen-specific T cells;Attenuated;B-Lymphocytes;Birth;Blood specimen;Characteristics;Child;Clinical Data;cohort;COVID-19 vaccination;COVID-19 vaccine;Data;Disease;disease model;Dose;early childhood;Ensure;Epitope Mapping;Epitopes;Fetus;Flow Cytometry;Future;glycosylation;high dimensionality;high risk;Hybrids;Immune response;Immunity;Immunization;immunogenic;Immunoglobulin G;Immunologic Memory;Immunologics;in utero;infancy;Infant;Infection;inhibiting antibody;insight;Length;Life;Masks;Maternal antibody;Memory;Memory B-Lymphocyte;Monoclonal Antibody Therapy;Multisystem Inflammatory Syndrome in Children;Natural Immunity;neutralizing antibody;neutralizing vaccine;Passive Transfer of Immunity;pathogen;Phenotype;placental transfer;post SARS-CoV-2 infection;Pregnancy;receptor;Recommendation;response;Risk;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;Series;Seroprevalences;severe COVID-19;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Time;time interval;Vaccination;vaccination strategy;Vaccine Antigen;vaccine response;Vaccinee;Vaccines

PROJECT_TITLE: Determinants of Early Childhood Immune Responses to SARS-CoV-2 Vaccination

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Nutrition;Patient Safety;Physical Activity;Prevention;Sleep Research;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Women with advanced hormone receptor (HR)+ breast cancer being treated with endocrine therapy in combination with an inhibitor of cyclin dependent kinase 4/6 (CDK4/6) inhibitor are at risk for debilitating fatigue which can lead to poor quality of life and reductions or even discontinuation of the medication. Lifestyle interventions, particularly exercise and intermittent fasting, are well-tolerated and favorably impact fatigue, biomarkers of inflammation, physical function, patient reported outcomes and body composition in women with early-stage breast cancer, however, there have been few studies in women with advanced breast cancer. To address this gap, we propose a 2 x 2 trial in 260 women with advanced HR+ breast cancer initiating treatment with hormonal therapy in combination with a CDK4/6 inhibitor, to evaluate the impact of either prolonged overnight fasting intervention alone, moderate-intensity exercise alone, or in combination on fatigue and associated inflammatory biomarkers.

PI_NAMEs: CRANE, TRACY E (contact);DIELI-CONWRIGHT, CHRISTINA ;LIGIBEL, JENNIFER A.

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: acceptability and feasibility;Address;advanced breast cancer;advanced disease;Advanced Malignant Neoplasm;Adverse effects;adverse outcome;Anxiety;Aromatase Inhibitors;attentional control;Attenuated;Biological Markers;Body Composition;C-reactive protein;cancer initiation;cancer therapy;Carbohydrates;CDK4 gene;chemotherapy;Chemotherapy and/or radiation;circadian;Circadian Rhythms;Cyclin-Dependent Kinase Inhibitor;Data;Development;Diet;diet and exercise;Dietary Intervention;Dose;Eating;Effectiveness;Enrollment;ethnic diversity;Evaluation;Exercise;exercise intensity;exercise intervention;exercise training;experience;Fasting;Fatigue;feasibility testing;Fulvestrant;gastrointestinal;Goals;hormone receptor-positive;hormone therapy;Hour;improved;improved outcome;improvement on sleep;Individual;Inflammation;Inflammatory;inflammatory marker;inhibitor;inhibitor therapy;Interleukin-6;Intermittent fasting;Intervention;intervention effect;Life;lifestyle intervention;Malignant Breast Neoplasm;Mediating;Menopausal Symptom;Mental Depression;Metastatic breast cancer;Minority Groups;Mood Disorders;Neutropenia;novel;Outcome;Outcome Study;Participant;Patient Outcomes Assessments;patient population;Patients;Pharmaceutical Preparations;Phase;phase II trial;Physical activity;Physical assessment;Physical Function;Pilot Projects;Population;post intervention;preservation;primary outcome;psychologic;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;Research;Risk;Sampling;secondary outcome;side effect;Sleep;Sleep disturbances;targeted treatment;Testing;TNF gene;Toxic effect;Treatment Side Effects;Treatment-related toxicity;tumor;Underrepresented Minority;Well in self;Woman;women's outcomes;Women's study

PROJECT_TITLE: Randomized Phase II Trial of Prolonged Overnight Fasting and/or Exercise on Fatigue and Other Patient Reported Outcomes in Women with Hormone Receptor Positive Advanced Breast Cancer (FastER)


NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Clinical Research;Comparative Effectiveness Research;Rheumatoid Arthritis

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE (Public Health Relevance Statement) Rheumatoid arthritis (RA) is a chronic, debilitating, inflammatory disease that disproportionally affects older adults, and those with late-onset RA (LORA) have more severe disease and disability. However, older adults are less likely to receive RA treatment that aligns with current clinical practice guidelines suggesting we may be accepting worse outcomes than what may be achievable. This study will inform future optimization of safe and effective medication use in this vulnerable population.

PI_NAMEs: LEE, JIHA  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acceleration;Acute;Adverse effects;Affect;Age;Age Years;Aging;Attitude;Biological;career development;Caring;Chronic;Clinical;clinical practice;Clinical Practice Guideline;Clinical Trials;clinically relevant;cohort;Combination Drug Therapy;Communication difficulty;comorbidity;Data;Dedications;Development;Diagnosis;disability;Disease;Disease-Modifying Second-Line Drugs;Dose;Drug usage;Elderly;Environment;Evaluation;evidence base;Exclusion;Exclusion Criteria;experience;Foundations;Frequencies;Future;Glucocorticoids;Goals;Guidelines;Healthcare;human old age (65+);improved;indexing;Infection;Inflammatory;Interview;Kidney;Knowledge;Liver Failure;Low income;Malignant neoplasm of liver;Measures;Medicare claim;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Michigan;Monitor;multilevel analysis;Newly Diagnosed;Observational Study;older adult;opioid use;osteoporosis with pathological fracture;Outcome;Patient Care;patient engagement;Patient Preferences;Patients;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacotherapy;Population;population based;Prednisone;Primary Care Physician;professor;Provider;public health relevance;Qualifying;radiological imaging;Recommendation;Regimen;Research;Research Methodology;Research Personnel;Research Proposals;Rheumatism;Rheumatoid Arthritis;rheumatologist;Rheumatology;Risk;Role;Sampling;Science;Scientist;standard of care;Steroids;Structure;symptomatic improvement;Time;Toxic effect;Training;treatment and outcome;treatment as usual;treatment choice;Treatment outcome;Treatment Protocols;Universities;Update;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Understanding disease modifying antirheumatic drug use in older adults with late-onset rheumatoid arthritis

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: Raman microscopy grants important advantages over other more common optical techniques, offering expanded multiplexing capabilities for simultaneous visualization of large numbers of distinct biomolecules and structures with high spatiotemporal resolution. This research project focuses on the development of next-generation Stimulated Raman Scattering (SRS) responsive molecular probes to be implemented with complementary SRS microscopy instrumentation to enable high-speed, super-multiplexed visualization of transient molecular species and dynamic processes in live cells

PI_NAMEs: BUCCELLA, DANIELA  (contact)

PROJECT_TITLE: Super-Multiplexed Molecular Sensing in Live Cells


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Microbes such as Bacteria influence the healthiness of their host in many different ways. To understand how the microbes interact with their host, we need tools to characterize the microbes spatial distribution and also their cellular status. This project aims to build a widely applicable spatial RNA and protein sequencing platform to understand microbe status, spatial organization and their interactions with their host.

PI_NAMEs: LIU, YANG  (contact)

PROJECT_TERMS: Antibiotic Therapy;Antibodies;Bacteria;Bar Codes;C57BL/6 Mouse;cell behavior;Cell Wall;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Complex;design;Development;Digestion;epigenomics;Escherichia coli;Gene Expression;Gene Expression Profile;Genomics;Germ-Free;Gram-Positive Bacteria;Half-Life;Heterogeneity;host-microbe interactions;Human;Inflammatory Bowel Diseases;Ligation;Malignant Neoplasms;Maps;Membrane Proteins;Messenger RNA;Microbe;microbial;Modeling;multiple omics;Neurosciences;pathogen;Pathway interactions;Patients;Peptide Sequence Determination;Poly(A) Tail;Polyadenylation Pathway;Population;prevent;Protocols documentation;Reagent;receptor;Reporting;Resolution;Reverse Transcription;RNA Sequences;RNA-Directed DNA Polymerase;sequencing platform;Slide;Spatial Distribution;Staphylococcus aureus;System;Techniques;Technology;Thick;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Spatially resolved multiomics profiling of microbes and their host tissue

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: FREDERICK

ORG_NAME: BIOLOGICAL MIMETICS, INC.

ORG_STATE: MD

PHR: Narrative Antibiotic-resistant bacteria are of critical concern to human health. MRSA is the leading cause of nosocomial infection in the USA. A vaccine that protects against MRSA infection is highly sought after; however, the development of S. aureus immunobiotics and vaccines is stymied due to antigenic variation and failure of protection. In this Phase I SBIR, we propose to use information learned from our previous studies with inactivated, whole-cell immunogens to test existing and modified candidates and derive a finalized vaccine candidate for future development.

PI_NAMEs: DOLLERY, STEPHEN JEFFREY (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Abscess;Acinetobacter baumannii;Acute;Acute Disease;Animal Model;Antibiotic Resistance;Antibiotics;Antigenic Variation;Antigens;Antioxidants;Bacteremia;Bacteria;Bacterial Antibiotic Resistance;bacterial resistance;Cells;Cessation of life;Chikungunya virus;Chronic;Chronic Disease;Clinical Trials;Complex;cost;Coupled;cross immunity;Data;Deceptive Imprinting;Deinococcus radiodurans;Development;Disease;Dose;Economic Burden;Endocarditis;Epitopes;experimental study;Exposure to;Failure;fighting;Future;Generations;Goals;Health;Healthcare;Healthcare Systems;Human;Human poliovirus;Immune;Immunity;Implant;implantable device;implantation;imprint;Incidence;Infection;Infectious Skin Diseases;inorganic phosphate;insight;Intensive Care;Investments;irradiation;lead candidate;Learning;Legal patent;Linezolid;Manganese;medical implant;Methicillin;methicillin resistant Staphylococcus aureus;Methods;Microbial Biofilms;mimetics;Modeling;mouse model;next generation;Nosocomial Infections;novel;Operative Surgical Procedures;Osteomyelitis;Patients;Persons;Phase;Pneumonia;Polysaccharides;Positioning Attribute;preclinical study;Preparation;preservation;Preventive measure;Preventive vaccine;Protein Subunits;prototype;radioresistant;Reagent;Reporting;Resistance;resistant strain;response;Set protein;Small Business Innovation Research Grant;Soft Tissue Infections;Staphylococcal Vaccines;Staphylococcus aureus;technology development;Testing;Toxic effect;United States;Urinary tract infection;vaccine candidate;Vaccines;Vancomycin;Venezuelan Equine Encephalitis Virus;Viral Vaccines;Whole Cell Vaccine

PROJECT_TITLE: Development of a Staph Aureus Vaccine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-U(11)]


NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Gene Therapy;Genetics;Neurosciences

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Microglia, the immune cells of the brain and spinal cord, are the next frontier for treating neurological diseases. This proposal will investigate how microglia provide protection against viral infection and aims to overcome that protection to enable gene and cell therapies. Completion of this project will identify methods to deliver genes to microglia to make “living drugs” and identify targets to defend the brain against infection.

PI_NAMEs: BENNETT, MARIKO L. (contact)

PROJECT_TERMS: Acceleration;Affect;Anti-Retroviral Agents;antiviral immunity;Award;Benchmarking;Bone Marrow;Brain;brain cell;Cell Therapy;Cells;Central Nervous System;Child Care;Childhood;Chimera organism;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Custom;design;Engineered Gene;Engineering;Ensure;frontier;Future;gain of function;Gene Expression;gene therapy;gene-editing approach;Genes;Genetic;Genetic Engineering;Genome;Goals;Growth;Herpes encephalitis;HIV;Immune;Impaired cognition;In Vitro;in vivo;Infection;inhibitor;Injury;insight;Institution;Interferons;Knock-out;Knockout Mice;lentivirally transduced;Lentivirus;leukodystrophy;Libraries;Light;Link;Macrophage;Mediating;Mediator;Mentors;Mentorship;Methods;Microglia;Molecular;multidisciplinary;Mus;Nervous System Disorder;Neuroglia;Neuroimmune;neuroimmunologic disease;Neurologic;Neurologist;Neurology;Neurons;novel strategies;novel therapeutics;Nucleic Acids;Pathogenesis;Pathway interactions;Patients;Pediatric Hospitals;Pharmaceutical Preparations;Philadelphia;Point Mutation;Postdoctoral Fellow;Predisposition;preservation;prevent;Production;professor;programs;receptor;Recombinant adeno-associated virus (rAAV);Regulation;Research;residence;Resistance;Resources;response;Role;sensor;Signal Transduction;single-cell RNA sequencing;Spinal Cord;Stimulator of Interferon Genes;Students;Surveys;targeted treatment;Testing;therapeutic target;therapy development;Tissues;tool;Training;transcriptome;transcriptomics;transduction efficiency;Transgenic Mice;Transplantation;Tropism;Validation;Vesicular stomatitis Indiana virus;Viral;Viral Physiology;Virus Diseases;Vision;Work

PROJECT_TITLE: Unlocking microglia targeting for neurotherapeutics


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Cerebrovascular;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative Pregnant women in many countries continue to consume moderate levels of alcohol, which might not result in neurobehavioral problems in their children but may still program the fetus for adulthood diseases. The proposed research is relevant to public health as it begins to address the health risks in adults exposed to moderate levels of alcohol in utero. The project is relevant to the mission of the National Institute of Alcohol Abuse and Alcoholism as it advances our fundamental knowledge about the mechanisms involved in increasing the severity of neurological disorders in adults exposed to moderate levels of alcohol in utero and apply that knowledge to reduce the related health consequences.

PI_NAMEs: PAUL, SUROJIT  (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Address;Adult;Adult Children;Adverse effects;Affect;Age;aged;Alcohol abuse;alcohol consumption during pregnancy;alcohol measurement;Alcoholism;Alcohols;Antioxidants;Attenuated;behavior test;Behavioral;binge drinking;Biochemical;Blood alcohol level measurement;Brain;Brain Diseases;Brain Injuries;Brain region;Characteristics;chemokine;Child;Chronic;Clinical;Cognitive;Communication;Compensation;Consumption;Control Groups;Country;Craniofacial Abnormalities;CX3CL1 gene;Data;Dimerization;Dinoprostone;disability;Disease;drinking;Electron Spin Resonance Spectroscopy;Etiology;Evaluation;excitotoxicity;experimental study;Exposure to;Female;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Alcohol Syndrome;Fetal Development;Fetus;Flow Cytometry;functional outcomes;Generations;glial activation;Glutathione;Glutathione Metabolism Pathway;Growth;Health;Homeostasis;Imaging Techniques;immune cell infiltrate;Impairment;in utero;Infarction;Inflammatory;Inflammatory Response;International;Ischemia;Ischemic Brain Injury;Ischemic Stroke;Knockout Mice;Knowledge;Life;life span;Link;loss of function;Magnetic Resonance Imaging;male;maternal alcohol use;middle age;Middle Cerebral Artery Occlusion;Mission;Molecular;mouse model;Mus;Nervous System Disorder;neurobehavioral;neurodevelopment;Neuroimmune;Neurologic;Neurological outcome;Neurons;neuroprotection;Neuroprotective Agents;Newborn Infant;novel;offspring;Outcome;Oxidative Stress;Pattern;Peptides;peptidomimetics;Peripheral;Pharmacology Study;Predisposition;Pregnancy;Pregnant Women;Premature Mortality;prenatal exposure;programs;Prostaglandins;Protein Tyrosine Phosphatase;Public Health;Reactive Oxygen Species;Recommendation;Research;restoration;Risk;Severities;sex;Signal Pathway;Signal Transduction;social;System;Testing;Up-Regulation

PROJECT_TITLE: Outcome of Neurological Disorders in Adults Exposed to Moderate Levels of Alcohol in Utero

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROGRAM NARRATIVE Esophageal adenocarcinoma (EAC) is a rapidly rising public health problem and its prognosis remains poor. Barrett's esophagus (BE) is the precursor to esophageal adenocarcinoma but it often goes undetected. The Program Project focuses on genetic and molecular studies that will develop better understanding of how reflux injury and repair result in development of BE and its progression to EAC in susceptible individuals. The ultimate goal is to develop improved methods for detecting BE, predicting its progression to EAC, and preventing BE from progressing to EAC.

PI_NAMEs: CHAK, AMITABH  (contact);GUDA, KISHORE

PROGRAM_OFFICER_NAME: RICHMOND, ELLEN S

PROJECT_TERMS: Address;Affect;Barrett Esophagus;Barrett's carcinogenesis;Basic Science;Bibliometrics;biobank;Bioinformatics;Biological Markers;Biology;c-myc Genes;cancer prevention;carcinogenesis;carcinogenicity;Cell Adhesion Molecules;Cell Communication;Cell Differentiation process;cell growth;cell motility;Cells;Clinical;clinical application;Collaborations;Complex;Detection;detection method;Development;Devices;Disease;Duct (organ) structure;Dysplasia;EPHB2 gene;Epithelial Cell Junction;Epithelium;Esophageal Adenocarcinoma;esophageal carcinogenesis;Esophageal injury;Esophagus;fusion gene;Genes;Genetic;genetic approach;Genetic Predisposition to Disease;Gland;Goals;Grant;healing;HNF4A gene;Hyperactivity;IL8 gene;improved;Individual;Inflammatory;Inflammatory Infiltrate;Inherited;Injury;injury and repair;Institution;instructor;Interdisciplinary Study;Laboratories;Laboratory Research;Laboratory Scientists;Lead;Legal patent;Manuscripts;MAPK8 gene;Mediating;Mediator;Metaplasia;Molecular;molecular marker;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mutate;notch protein;novel;Pathway interactions;Pattern;Phenotype;Population;precursor cell;Predisposition;prevent;Prevention;professor;Prognosis;programs;Public Health;Publishing;Reflux;repaired;Research;Research Personnel;Research Project Grants;Resources;response to injury;risk stratification;Role;Sampling;screening;Services;Signal Pathway;Signal Transduction;Signaling Molecule;Specialized Program of Research Excellence;Squamous Epithelium;Submucosa;support network;Susceptibility Gene;synergism;System;TGFB1 gene;Therapeutic;Tissues;transcription factor;transcriptomics;Translating;Translational Research;Universities;wound healing;wound response

PROJECT_TITLE: Pathways of Injury and Repair in Barrett's Carcinogenesis


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Esophageal Cancer;Genetics;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE Barrett's esophagus is a complex disorder and patients with Barrett's esophagus are at an increased risk of developing esophageal adenocarcinoma, a lethal and most common esophageal malignancy in the United States. To date, the mechanisms contributing to the onset and malignant progression of Barrett's esophagus remain poorly understood. Our proposed studies are accordingly designed to unravel the molecular underpinnings of Barrett's esophagus and associated esophageal malignancy, with an overarching goal of developing evidence-based biomarkers and rational chemopreventive/therapeutic strategies for this increasingly prevalent and complex disease.

PI_NAMEs: CHAK, AMITABH  (contact)

PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;Address;Affect;Age Months;Barrett Esophagus;Barrett's carcinogenesis;Barrett's neoplasia;Biological Assay;Biological Markers;Biopsy;cancer prevention;carcinogenesis;Cell-Cell Adhesion;Cells;Chemopreventive Agent;clinical implementation;comparison control;Complement 3d;Complex;deoxycholate;design;Desmosomes;Development;Disease;Distal;Duct (organ) structure;Dysplasia;Electron Microscopy;Ephrin-B2;Epithelium;Esophageal Adenocarcinoma;Esophageal injury;Esophageal mucous membrane;Esophagus;Etiology;evidence base;Exhibits;exome sequencing;experimental study;Exposure to;Family;follow-up;Functional disorder;Genes;Genetic;genotoxicity;Genotype;Germ Lines;Germ-Line Mutation;Gland;Goals;healing;Homeostasis;Human;human subject;Impairment;indexing;induced pluripotent stem cell;Inflammation;Inherited;Injury;injury and repair;Intercellular Junctions;Interleukin-1 beta;interstitial;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Lead;Lesion;Malignant - descriptor;Malignant Neoplasms;Metaplasia;Methods;microscopic imaging;Modeling;Molecular;Molecular Genetics;Morphology;mouse model;Mucous Membrane;Mus;mutant;Mutant Strains Mice;Mutation;novel;old mice;Organoids;Orthologous Gene;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Patients;Phenotype;Phosphotransferases;Pilot Projects;Predisposition;prevent;programs;prospective;Recurrence;Reflux;Risk;Role;segregation;Signal Transduction;Squamous Cell;Squamous Differentiation;Squamous Epithelium;Submucosa;synergism;Testing;Therapeutic;Tissues;transcriptomic profiling;transdifferentiation;translational goal;United States;Variant;wound healing

PROJECT_TITLE: Deciphering the Molecular Genetics of VSIG10L in Barrett's Neoplasia


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Brain Disorders;Clinical Research;Data Science;Disability Research;Machine Learning and Artificial Intelligence;Multiple Sclerosis;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Successful completion of this project will lead to the development and dissemination of clinically relevant predictive algorithms to enable personalized risk assessment and therapeutic decision-making in MS, provide the means to optimize selection/stratification of participants in clinical trials, and will also provide insight regarding the interactions and relative importance of putative prognostic factors in MS.

PI_NAMEs: SOTIRCHOS, ELIAS S (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Algorithms;Architecture;Award;Benign;Big Data;biobank;Biological Markers;Biostatistical Methods;Blood specimen;Brain;career;Characteristics;Clinical;clinical practice;clinical risk;Clinical Trials;clinically relevant;comorbidity;Computerized Medical Record;Counseling;Data;Data Set;Decision Making;Demographic Factors;demographics;design;Development;Devices;dexterity;Digit structure;disability;disability risk;Disability scale;Disease;Disease Outcome;Electronics;Elements;Enhancing Lesion;Enrollment;Exhibits;follow-up;foot;Future;Goals;gray matter;Hand;Health;Health system;Image;improved;Individual;Inflammatory;insight;inter-individual variation;Laboratories;Learning;Lesion;lifestyle factors;Light;machine learning method;Magnetic Resonance Imaging;Manuals;Measures;Medical;Modality;Modeling;Monitor;multidimensional data;multimodality;Multiple Sclerosis;multiple sclerosis patient;neurofilament;neuroimaging;novel;novel diagnostics;Outcome;Participant;Patient Care;Patients;performance tests;personalized medicine;Phenotype;Population;prediction algorithm;Predictive Value;processing speed;prognostic;Prognostic Factor;Recording of previous events;Relapse;Reporting;Research;Research Personnel;response;Risk Assessment;Risk Factors;risk prediction;risk prediction model;Serum;Severity of illness;Standardization;statistical and machine learning;Stratification;Technology;Testing;Therapeutic;tool;Training;Universities;Validation;Visit;Walking;walking speed

PROJECT_TITLE: Prediction of risk of disability worsening and inflammatory disease activity in MS utilizing multimodal prediction algorithms

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Thousands of children are born blind in around the world, often due to genetic hereditary abnormalities or environmental factors. In this proposal, we will examine the functional and neuroanatomical changes to the posterior parietal cortex that emerge with early loss of vision, and determine if these changes confer compensatory behaviors on congenitally blind individuals. We will investigate these changes at two important developmental stages. These data can influence therapeutic interventions and allow predictions for behavioral outcomes following such therapies.

PI_NAMEs: PINEDA, CARLOS RODRIGO (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Acoustic Stimulation;Address;Adult;Affect;Age;Age of Onset;Anatomy;Animals;Area;Auditory;Auditory area;auditory processing;auditory stimulus;Axon;Behavior;behavior prediction;behavior test;Behavioral;behavioral outcome;Bilateral;blind;Blindness;Brain;Cannulas;Child;Compensation;Cortical Blindness;Data;Development;Electrophysiology (science);Environment;Environmental Risk Factor;experience;experimental study;fluorophore;Genetic;Goals;grasp;Human;Impairment;Implant;Inherited;kinematics;Laboratories;Lateral;machine learning algorithm;Mammals;mature animal;Medial;Mediating;Microinjections;Modality;Monodelphis;Monodelphis Domestica;Movement;multimodality;Muscimol;Neocortex;neural;Neuroanatomy;Neurons;Occipital lobe;Parietal Lobe;Pathway interactions;Performance;Property;receptive field;Research;response;Retina;retinogeniculate;Rodent;Sensory;sensory input;Sensory Receptors;sensory system;Shapes;somatosensory;Somatosensory Cortex;Tactile;tactile stimulation;Task Performances;Thalamic Nuclei;Thalamic structure;Therapeutic Intervention;Time;Tracer;Vibrissae;Vision;Visual;visual stimulus;Visually Impaired Persons;Work

PROJECT_TITLE: Cross-modal plasticity after the loss of vision at two early developmental ages in the posterior parietal cortex: Adult connections, cortical function and behavior.


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Machine Learning and Artificial Intelligence;Racial and Ethnic Minority Health Research

ORG_CITY: ENTEBBE

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: UGANDA VIRUS RESEARCH INSTITUTE

ORG_ZIPCODE: EBB

PHR: Project Narrative The goal of the proposed work is to leverage existing genomic data of blood cell traits from the H3Africa and other initiative across Africa for novel gene discovery and genetic risk prediction in Africa ancestry individuals. The findings from this study will provide insight into genetic architecture of blood cell traits and the applicability of polygenic risk scores of these traits in enhancing disease prediction in Africa.

PI_NAMEs: CHIKOWORE, TINASHE ;FATUMO, SEGUN  (contact);KUMA, AMA BENNEH-AKWASI

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Address;Africa;African;African American;African American population;African ancestry;Asian ancestry;Blood Cells;Blood Platelets;Cardiovascular Diseases;case control;clinical phenotype;Collaborations;Collection;Communicable Diseases;computing resources;convolutional neural network;Data;Data Discovery;Data Science;Data Set;Development;Diabetes Mellitus;Diagnosis;Disease;Disease Outcome;Disease susceptibility;drug development;East Asian;Elasticity;Environment;Erythrocytes;Ethnic Origin;Etiology;European;European ancestry;Evaluation;Exposure to;Funding;gene discovery;Genetic;genetic architecture;genetic association;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome analysis;genome resource;genome wide association study;genomic data;genomic locus;Genomics;Goals;Health;health data;Health Policy;Health Sciences;Hematological Disease;Heredity;Heritability;Human;Hypertension;improved;Individual;Infection;information gathering;insight;Institution;Knowledge;leukemia;Leukocytes;Linkage Disequilibrium;Machine Learning;Maps;Meta-Analysis;Mission;Modeling;multilayer perceptron;Nigeria;novel;open data;Persons;phenome;Play;polygenic risk score;Polygenic Traits;Population;Predisposition;pressure;Public Health;Publishing;Research;Resolution;Resource-limited setting;Resources;Risk;Risk Factors;risk prediction;Role;Severity of illness;Shapes;Sickle Cell Anemia;Signal Transduction;Strategic Planning;Stroke;Techniques;Testing;Therapeutic;Training;trait;Treatment outcome;United States National Institutes of Health;Variant;Work;working group

PROJECT_TITLE: BCX-Africa: Utilizing data science to evaluate the applicability of blood cell traits polygenic risk scores for disease prediction in Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-L(70)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: Buea

ORG_COUNTRY: CAMEROON

ORG_FIPS: CM

ORG_NAME: HEALTH RESEARCH FOUNDATION

PHR: Artificial Intelligence assisted echocardiography to facilitate optimal image  extraction for congenital heart defects diagnosis in Sub-Saharan Africa Narrative Congenital heart defects (CHD) is a major contributor to under-5 deaths in Sub-Saharan Africa (SSA), owing to the lack of paediatric cardiologist experts who can perform an echocardiography scan for early diagnosis. The current project seeks to develop an artificial intelligence assisted model that will allow local non-experts such as nurses who work in birthing centres, to conduct an echocardiography scan and extract optimal images which can sent to a remote expert for interpretation and diagnosis confirmation. This will remove the burden and risk of travelling hundreds of kilometers to expert centres mainly located in cities, increase early diagnosis and initiation of care remotely, and reduce the workload on the few available experts.

PI_NAMEs: LEKE, AMINKENG ZAWUO (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Address;Affect;Africa;Africa South of the Sahara;Artificial Intelligence;artificial intelligence model;Awareness;Birthing Centers;Cardiac;Caring;Cessation of life;Cities;Classification;clinical practice;Clip;congenital anomaly;Congenital Heart Defects;cost;Data Science;design;Detection;Diagnosis;diagnostic value;Early Diagnosis;Early treatment;Echocardiography;Feedback;Future;Goals;Health;Heart;Image;improved;Infant;Instruction;Label;Midwife;Mission;Modeling;Modernization;Morbidity - disease rate;mortality;neonate;new technology;Newborn Infant;Nurses;Parents;Patients;pediatric cardiologist;Performance;postnatal;Prediction of Response to Therapy;prenatal;Prenatal Diagnosis;Procedures;programs;Pulse Oximetry;remote health care;Resource-limited setting;Risk;Scanning;screening;skills;Stream;Technology;Testing;Time;Training;Training Programs;transmission process;Travel;uptake;Work;Workload


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Esophageal Cancer;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Esophageal and gastroesophageal junction adenocarcinomas remain cancers associated with poor survival, and current preventive strategies have been limited in reducing this high mortality. Improvements in screening and preventive approaches may emerge from more complete understanding of how esophageal adenocarcinomas arise in the context of chronic injury and abnormal wound healing. We focus on esophageal submucosal glands as a potential source of progenitor cells in the esophagus where we have observed inflammation and we now propose experiments to understand this microenvironment and how it may influence wound healing with the goal of identifying more effective preventive strategies to reduce cancer risk and improving current strategies for esophageal cancer interception.

PI_NAMEs: GARMAN, KATHERINE  (contact)

PROJECT_TERMS: Acids;Acinus organ component;Acute;Address;Adenocarcinoma Cell;Aftercare;Area;Barrett Esophagus;Barrett's carcinogenesis;Biological Markers;biomarker identification;cancer prevention;cancer risk;carcinogenesis;Cells;chemokine;Chemoprevention;Chemopreventive Agent;Chronic;Clinical;Coculture Techniques;cohort;Complex;cytokine;Databases;Development;Disease;Distal;Duct (organ) structure;Dysplasia;epithelial stem cell;Epithelium;Esophageal Adenocarcinoma;Esophageal injury;Esophagectomy;Esophagogastric Junction;Esophagus;Etiology;evidence base;Excision;experimental study;Family suidae;gastroesophageal junction adenocarcinoma;Gastroesophageal reflux disease;Gene Expression;Genes;Gland;Goals;healing;High grade dysplasia;Histologic;Human;IL8 gene;Immune;immune cell infiltrate;immunoregulation;improved;improved outcome;in vivo;Individual;Inflammation;Inflammatory;Inherited;Injury;injury and repair;insight;Intervention;Knowledge;Lesion;Ligands;Malignant - descriptor;Malignant neoplasm of esophagus;Malignant Neoplasms;Mediating;Metaplasia;Modeling;Molecular;Molecular Profiling;mortality;Mucinous;Mucous Membrane;Names;Non-Steroidal Anti-Inflammatory Agents;Organ;Organoids;Outcome;Pancreas;Pathogenesis;Pathway interactions;Patients;Pattern;Phenotype;Population;pre-clinical;Predisposition;prevent;Prevention;Prevention strategy;Preventive;Process;progenitor;Program Research Project Grants;programs;Proliferating;Radiofrequency Interstitial Ablation;recruit;Recurrence;Reflux;Refractory;repaired;Reporting;Research;Residual state;response to injury;Risk;Role;Sampling;screening;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Source;spatiotemporal;Specimen;Squamous Cell;stem cells;stomach cardia;Submucosa;synergism;Testing;Therapeutic;Transitional Cell;Treatment Failure;tumor;tumor-immune system interactions;wound healing

PROJECT_TITLE: Inflammation And Submucosal Glands During Esophageal Injury And Repair


ORG_CITY: PARKTOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: WITS HEALTH CONSORTIUM (PTY), LTD

PHR: Narrative The ILERA study aims to build integrated models for early risk prediction to address the rising burden of non- communicable diseases (focusing on cardiometabolic diseases and associated traits) in many African countries, taking into consideration the predictive power of genetic risk scores when combined with predicted gene expression data and non-genetic (environmental and lifestyle) information. The models will be developed using data from South African participants and evaluated in independent cohorts from south, west and east Africa, as well as examining age-related effects in longitudinal data. The methods and models that best predict the cardiometabolic disease outcomes will be used to stratify populations according to risk categories and their potential translation into early warning systems will be investigated.

PI_NAMEs: CHOUDHURY, ANANYO  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, MAKEDA J

PROJECT_TERMS: Address;Adipose tissue;Africa;African;Age;age effect;biomarker identification;Blood;Blood Pressure;Body mass index;Burkina Faso;Cardiometabolic Disease;Categories;Cessation of life;Cholesterol;cohort;Collaborations;Communicable Diseases;Complex;Country;Data;Data Collection;Data Science;Data Set;deep learning;Diastolic blood pressure;Diet;Disease;Disease Outcome;disorder risk;Drug Targeting;Drug usage;Environment;European;Evaluation;Exercise;experience;extend lifespan;functional genomics;Gene Expression;Generations;Genetic Risk;genome resource;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Genotype-Tissue Expression Project;Ghana;Grant;Health;Health Priorities;Healthcare;High Density Lipoproteins;high risk;Hypertension;improved;Individual;Industrialization;industry partner;insight;Kenya;Kidney Diseases;Life Style;Lipids;Low-Density Lipoproteins;Medical center;Methods;Modeling;multiple omics;non-genetic;novel;Obesity;Participant;polygenic risk score;Population;population based;population stratification;predictive modeling;premature;public health intervention;Pulse Rates;Quality of life;Renal function;Research;Resource-limited setting;Risk;risk prediction;risk prediction model;Science;Smoking;Socioeconomic Status;South Africa;South African;statistics;subcutaneous;System;Technology;Testing;Time;trait;transcriptome;transcriptome sequencing;transcriptomics;translational potential;Triglycerides;Universities;Variant;Visceral;Waist-Hip Ratio;Whole Blood;whole genome;Wit;Zimbabwe

PROJECT_TITLE: Integrated modeLs for Early Risk-prediction in Africa (ILERA) study


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: BLUM, ANDREW EDWARD (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Animal Model;Barrett Esophagus;Barrett's carcinogenesis;Barrett's neoplasia;Bile Acids;Binding;Binding Proteins;Biological;Biological Markers;Biopsy;c-myc Genes;cancer prevention;carcinogenesis;Cell Line;Cell Lineage;Cells;Chemopreventive Agent;clinical implementation;Complex;Coupled;design;Development;Disease;Disease Progression;Distal;Dysplasia;EPHB2 gene;Ephrin-B2;Epithelium;Esophageal Adenocarcinoma;Esophageal injury;Esophageal mucous membrane;Esophageal Squamous Cell;Esophagus;Etiology;evidence base;Exposure to;Family suidae;Gastroenterology;Genetic Transcription;genome-wide;Gland;Goals;Human;In Situ;In Vitro;in vivo;Inflammation;Inflammatory;Inherited;Injury;injury and repair;Interleukin-1 beta;Intestines;Lesion;Link;Malignant - descriptor;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metaplasia;Modeling;Molecular;molecular shape;mouse model;Mucous Membrane;Mus;Neoplasms;NF-kappa B;novel;Organoids;Pathogenesis;Pathologic;Pathway Analysis;Pathway interactions;Patients;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;preclinical study;precursor cell;Predisposition;progenitor;programs;promoter;Receptor Protein-Tyrosine Kinases;Reflux;Regulation;Risk;Risk Factors;Rodent Model;Role;Signal Transduction;single-cell RNA sequencing;Source;stem cells;Submucosa;synergism;Testing;Therapeutic;Time;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Transitional Cell;tumor growth;ubiquitin-protein ligase;United States;wound healing

PROJECT_TITLE: EPHB2-Dependent Signaling: A New Molecular Paradigm in Barrett's Neoplasia


NIH_SPENDING_CATS: Cancer;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE We will examine existing quality measures that define avoidable hospital care among adults with cancer and compare their performance to in-depth clinician reviews of medical records. We will recategorize hospital visits into actionable clinical scenarios to help cancer providers identify avoidable hospital visits and create a new quality measure to identify conditions that could be treated in oncology urgent care clinics. We will validate findings with patients and emergency clinicians, then survey cancer care providers nationwide to ensure that these categories and quality measure are accurate and useful.

PI_NAMEs: HONG, ARTHUR SEOKJAE (contact)

PROGRAM_OFFICER_NAME: DAVIDOFF, AMY

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;Admission activity;Adult;Agreement;Ambulatory Care;Applications Grants;Automobile Driving;Black race;cancer care;cancer diagnosis;Cancer Patient;care delivery;care providers;Caring;Categories;chemotherapy;Classification;Clinic;Clinical;clinically actionable;Code;Community Hospitals;Computerized Medical Record;cost;Cost aspects;Data;data exchange;data integration;Data Set;Diagnosis;Diarrhea;Disease;electronic structure;Emergency department visit;Emergency Situation;Environment;Feedback;Future;Goals;Health;Health system;Hispanic;hospital care;Hospitals;Immunotherapy;improved;Inpatients;Insurance;Interview;Link;Malignant Neoplasms;Managed Care;Measurement;Measures;Medical Records;Medicare;Modeling;National Comprehensive Cancer Network;Nausea;Nausea and Vomiting;Oncology;Organization and Administration;Outpatients;Pain;Paracentesis;Participant;Patients;payment;Performance;Procedures;programs;prospective;Provider;Radial;Reporting;safety net;Sampling;Sensitivity and Specificity;Services;Specific qualifier value;success;Surveys;theories;treatment effect;Triage;tumor registry;Uninsured;urgent care;Visit;Vomiting;Work

PROJECT_TITLE: Actionable categories of avoidable hospital care among adults with cancer

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Esophageal Cancer;Prevention;Rare Diseases

PROJECT_TERMS: Address;Administrator;Barrett Esophagus;Barrett's carcinogenesis;Biological Markers;Biology;Budgets;c-myc Genes;cancer prevention;carcinogenesis;Chemopreventive Agent;Clinical;Communication;Complex;design;Development;Disease;Duke Comprehensive Cancer Center;Dysplasia;Ensure;Esophageal Adenocarcinoma;Esophageal injury;Esophagus;evidence base;experience;Financial Activity;Generations;Genetic;Goals;Growth and Development function;Human Resources;Individual;Inherited;injury and repair;Institution;Internet;Leadership;Malignant - descriptor;Malignant Neoplasms;medical schools;meetings;member;Metaplasia;Mission;Modeling;Molecular;molecular marker;Molecular Target;Monitor;Morbidity - disease rate;mortality;Pathway interactions;Patients;Predisposition;Prevention;Principal Investigator;Program Development;Program Evaluation;programs;Progress Reports;Reporting;Research;Research Project Grants;Resources;Risk;Schedule;Scientific Evaluation;screening;Services;Structure;success;symposium;synergism;Systems Biology;Therapeutic;Time;timeline;transcriptomics;Translating;Translational Research;United States;United States National Institutes of Health;Universities;wasting;wound healing

PROJECT_TITLE: Administrative Core