ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Diabetes;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Narrative There is increasing evidence that diet and lifestyle are important risk factors for cognitive impairment particularly Alzheimer’s Disease. Obesity, diabetes, hypertension, cholesterol, and smoking are all risk factors for cognitive impairment and dementia in old age and they can even cause cognitive deficits in young adults. We will feed rabbits a low dose of cholesterol, a high-fat diet, or a diet high in both sugar and fat to determine if these diets produce the cellular, neuropathological, and cognitive hallmarks of late-onset Alzheimer’s Disease.

PI_NAMEs: SCHREURS, BERNARD G. (contact)

PROGRAM_OFFICER_NAME: MORO, MANUEL H

PROJECT_TERMS: abeta accumulation;Acetylcholinesterase;Adult;Affect;Alloxan;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Animals;Behavioral;Blood - brain barrier anatomy;Carrier Proteins;cerebrovascular;Characteristics;Chemicals;Cholesterol;Choline O-Acetyltransferase;Clinical;Clinical Trials;clinically relevant;Cognitive;Cognitive deficits;cognitive function;comorbidity;Complex;Data;Dementia;Dendritic Spines;Deposition;Diabetes Mellitus;Diet;dietary manipulation;Discrimination;Discrimination Learning;Dose;Electrophysiology (science);Epidemiology;eyeblink conditioning;Fatty acid glycerol esters;feeding;Female;Goals;Hepatotoxicity;High Fat Diet;Hippocampus;Human;human old age (65+);hypercholesterolemia;Hyperglycemia;Hypertension;Impaired cognition;Impairment;improved;innovation;lard;Late Onset Alzheimer Disease;Learning;Life Style;lipid transport;long term memory;Long-Term Potentiation;male;Membrane;Memory;Microglia;Modeling;Morphology;mouse model;Neurobiology;Neuronal Plasticity;neuropathology;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Oryctolagus cuniculus;Pathology;Plants;Positioning Attribute;Predictive Value;Prefrontal Cortex;prevent;Publishing;Research;Risk Factors;Rodent Model;Serum;Slice;Smoking;Soybean Oil;sugar;Superoxide Dismutase;Synaptic plasticity;tau Proteins;Testing;Transgenic Mice;Translating;translational potential;vascular inflammation;Ventricular;young adult

PROJECT_TITLE: Dietary manipulations in rabbits induce the cellular, neuropathological, and cognitive hallmarks of late-onset Alzheimer's Disease


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Dietary Supplements;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Prenatal alcohol exposure disrupts physical, brain and behavioral development, leading to a range of fetal alcohol spectrum disorders (FASD), a serious, global, and costly public health concern. It is critical that we identify effective treatments for reducing FASD, particularly the cognitive deficits. This proposal will examine how nutritional and behavioral factors modify the severity of FASD, which has important implications for treatment of FASD, and improving the quality of life of affected individuals.

PI_NAMEs: THOMAS, JENNIFER D (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Acetylcholine;adult neurogenesis;Adverse effects;adverse outcome;Affect;alcohol consumption during pregnancy;alcohol effect;alcohol exposure;Alcohol-Related Neurodevelopmental Disorder;Alcohols;Animal Model;Association Learning;Attention;Behavior;Behavioral;behavioral outcome;Brain;Cell membrane;Cells;Central Nervous System;Chemistry;Child;Choline;Choline Deficiency;choline supplementation;cholinergic;Clinical;Clinical Trials;Cognitive;cognitive capacity;Cognitive deficits;cognitive function;Combined Modality Therapy;cost;Data;Development;Diet;dietary;Dietary intake;DNA Methylation;drinking;Dysmorphology;Economics;effective intervention;effective therapy;embryo/fetus;Emotional;Ethanol;executive function;Exhibits;experience;Face;Family;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Reduction;Functional disorder;functional plasticity;Gene Expression;Growth;Health Care Costs;Hippocampus;Impairment;improved;Individual;Intake;Intervention;Learning;Live Birth;Long-Term Potentiation;Mathematics;Memory;Metabolism;Modeling;Motor Skills;nervous system development;neural;neural circuit;Neuronal Dysfunction;Neuronal Plasticity;neuropathology;Neurotransmitters;Nutrient;Nutritional;offspring;Pathology;Performance;Population;postnatal;postnatal period;Pregnancy;Pregnant Women;prenatal;Process;Public Health;Quality of life;Rattus;Regulation;Reversal Learning;Severities;skills;social;social skills;Supplementation;Teratogenic effects;Toddler;Translating;white matter

PROJECT_TITLE: Fetal Alcohol Effects and Choline Intervention

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE/ Spinal cord injury (SCI) is a devastating syndrome often characterized by comorbid damage to extremities. The proposed project explores the spinal cellular mechanisms engaged by concomitant peripheral injuries and limb disuse in SCI, and tests their contribution to spasticity/hyper-reflexia and chronic spinal recovery impairments. These studies may provide novel targets for improving recovery after SCI.

PI_NAMEs: FERGUSON, ADAM R (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: 3-Dimensional;Acute;AMPA Receptors;Automobile Driving;Bed rest;Behavioral;Bioinformatics;Biological;Biological Assay;central pain;Chronic;Clinical;clinically relevant;comorbidity;Complex;Confocal Microscopy;Data;Dendrites;Development;Drug Modulation;Electrophysiology (science);epidemiology study;Functional disorder;gain of function;Genes;genetic regulatory protein;Glutamate Receptor;Glutamates;Goals;Hindlimb;Hindlimb Suspension;Horns;Human;Hyperreflexia;Image;Impairment;improved;Individual;Injury;injury recovery;innovation;innovative technologies;Intervention;Intractable Pain;Lesion;Limb structure;Link;Locomotion;Locomotor Recovery;Mediating;Membrane;Modality;Modeling;Molecular;Molecular Profiling;Motor;motor disorder;Motor Neurons;mouse model;nerve injury;neurological rehabilitation;neuronal cell body;Neuronal Plasticity;Neurons;new therapeutic target;Nociception;novel;Pain;patch clamp;Pathway Analysis;Pathway interactions;Peripheral;Peripheral nerve injury;pharmacologic;Pharmacotherapy;Phase;Phenotype;Phosphorylation;Proteins;Publishing;Quantitative Reverse Transcriptase PCR;Recovery;Recovery of Function;Reflex action;Refractory;Regulation;Rehabilitation therapy;Reproducibility;Research;restoration;Robotics;Sensorimotor functions;Serine;sex;sham surgery;Shapes;Slice;spasticity;Spinal;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;Spinal Cord Plasticity;Spinal Cord transection injury;Stimulus;Synapses;Synaptic plasticity;Synaptosomes;Syndrome;System;Tactile;Technology;Testing;Therapeutic;trafficking;Training;transcriptome sequencing;transcriptomics;Transgenic Mice;Transgenic Organisms;Translations;trauma centers;Western Blotting;Work

PROJECT_TITLE: Maladaptive Plasticity in Spinal Cord Injury: Cellular Mechanisms

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE: The goal of this proposal is to provide key preclinical data and biomarkers for the combination of two FDA-approved cancer drugs (i.e., tazemetostat and anti-PD1 therapies) for breast cancer patients. Specifically, we hypothesize that in breast cancer patients, the overexpression of a lncRNA, EPIC1, is a master regulator of immunotherapy resistance by activating EZH2. We have designed mechanistic and translational experiments to test (1) whether EPIC1 induces immunotherapy resistance by activating EZH2 in breast cancer and (2) whether EZH2 inhibitor treatment can enhance responses to PD-1 antagonists for EPIC1-EZH2-activated breast cancer tumors.

PI_NAMEs: YANG, DA  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: 4T1;Animal Cancer Model;antagonist;anti-CTLA4;anti-PD-1;anti-PD-L1;anti-PD1 therapy;anti-tumor immune response;Antigen Presentation;Antigen Presentation Pathway;Antineoplastic Agents;Biological Assay;Biological Markers;Biology;Breast Cancer Patient;breast cancer progression;cancer immunotherapy;cancer therapy;Cells;ChIP-seq;chromatin isolation by RNA purification sequencing;Clinical;Clinical Investigator;Coculture Techniques;Cytotoxic T-Lymphocytes;Data;Databases;design;DNA Methylation;efficacy testing;Epigenetic Process;epigenetic silencing;Epithelioid Sarcomas;experience;experimental study;Exposure to;EZH2 gene;FDA approved;Gene Expression;Gene Expression Profiling;Gene Silencing;Genes;Genetic;genomic profiles;Goals;Human;humanized mouse;IFNGR1 gene;Immune;Immune Evasion;Immune system;Immunoprecipitation;Immunosuppression;Immunotherapy;In Situ Hybridization;In Vitro;in vivo;Infiltration;inhibitor;Interferon Type II;knock-down;large cell Diffuse non-Hodgkin's lymphoma;Lymphocyte Activation;Lymphocytic Infiltrate;Malignant Breast Neoplasm;Mammary Neoplasms;Measures;Mechanics;Mediating;MHC Class I Genes;mouse model;Mutate;Neoplasm Metastasis;neoplastic cell;novel;Nucleotides;Outcome;overexpression;Pathology;PD-1/PD-L1;pembrolizumab;pharmacologic;Play;pre-clinical;Primary Neoplasm;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;promoter;Proteins;Publications;recruit;Research;Resistance;Resolution;response;RNA;RNA Binding;Role;Sampling;Signal Transduction;Specimen;STAT1 gene;T-Lymphocyte;Technology;Testing;Therapeutic Effect;therapy resistant;translational scientist;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor initiation;tumor progression;Tumor Tissue;Untranslated RNA

PROJECT_TITLE: LncRNA EPIC1 induces immunotherapy resistance by activating EZH2 in breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cervical Cancer;Clinical Research;Genetics;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Cervical cancer, while curable when caught earlier, remains a leading cause of death in low-and-middle- income countries. Inadequate screening tactics arise from various factors including pathology bottlenecks, costs, clinical bandwidth, and turnaround times. We propose to advance a low-cost and fast portable platform (based on Nobel Prize-winning technology) for point-of-care and integrated cervical cancer screening in Uganda and Ghana. If successful, cervical cancers would be identified earlier through a sustainable, decentralized approach.

PI_NAMEs: CASTRO, CESAR M (contact);LEE, HAKHO

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Acetic Acids;Adopted;Africa South of the Sahara;Algorithms;Anisotropy;Automobile Driving;Benchmarking;Bioinformatics;Biological Assay;Biomedical Engineering;Budgets;cancer invasiveness;Cause of Death;CDKN2A gene;Cervical;Cervical Cancer Screening;Cessation of life;Clinical;clinical diagnostics;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complement;cost;Country;Cytology;Cytopathology;Decentralization;Detection;detection method;Developed Countries;Diagnostic;Disease;DNA;DNA Markers;Early identification;Eligibility Determination;empowerment;Equipment;expectation;Feedback;Fluorescence Anisotropy;Fruit;General Hospitals;Genes;Ghana;global health;Guidelines;Gynecologic Oncology;high risk;HPV screening;HPV-High Risk;Human;Human papilloma virus infection;Human Papillomavirus;Human Resources;Incidence;innovation;interest;International;Intervention;iterative design;Laboratories;low and middle-income countries;Machine Learning;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Massachusetts;Measurement;member;Messenger RNA;Motion;multidisciplinary;multimodality;news;Nobel Prize;novel;nucleic acid detection;Nucleic Acids;Oncogenic;operation;Optics;overtreatment;pandemic disease;Pap smear;Pathology;Performance;pilot test;point of care;portability;Positioning Attribute;Provider;Public Health;Reporter;Resource-limited setting;Resources;response;Risk;RNA;RNA marker;Sampling;Science;screening;Site;Specificity;Specimen;System;Technical Expertise;Technology;Temperature;Testing;Time;Traction;Triage;Uganda;Universities;UPK2 gene;user-friendly;Viral;Visual;Woman;Women's mortality

PROJECT_TITLE: Composing CODAs to cervical cancer screening through an integrated CRISPR and fluorescent nucleic acid approach


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Social memory dysfunction is a hallmark symptom of many neuropsychiatric illnesses, including autism spectrum disorder, major depressive disorder, schizophrenia, and Alzheimer's disease. The proposed research will describe the contribution of hippocampal structural plasticity, and in particular the role of adult-born neurons, to social memory circuits and function. Understanding the mechanistic impact of adult-born neurons to social memory circuits will reveal novel strategies for alleviating social memory deficits associated with neuropsychiatric illness.

PI_NAMEs: COPE, ELISE C (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Ablation;Adult;adult neurogenesis;Affect;Afferent Neurons;Alzheimer's Disease;autism spectrum disorder;Behavioral;brain circuitry;Brain region;cell type;Cells;Clinical;Cognitive;Data;Date of birth;dentate gyrus;Development;Electrophysiology (science);Event;experimental study;Frequencies;functional improvement;Generations;Genetic;Goals;Hippocampus;Histologic;Impairment;improved;in vivo;Individual;innovation;Intervention;Knockout Mice;Life;Maintenance;Major Depressive Disorder;member;Memory;memory consolidation;Memory impairment;memory process;memory recall;model of autism spectrum disorder;mouse model;Mus;nerve supply;neural circuit;neural stimulation;neuronal circuitry;Neurons;neuropsychiatric disorder;neuropsychiatric symptom;neuropsychiatry;novel;novel strategies;Pathway interactions;Patients;Performance;Pharmacogenetics;pharmacologic;Process;Publishing;Quality of life;recruit;Research;Role;Schizophrenia;Site;social;social deficits;social influence;social relationships;Source;Symptoms;Testing;therapeutic target;Transgenic Mice;Transgenic Organisms;Wild Type Mouse;Work

PROJECT_TITLE: Hippocampal adult-born neurons in social memory circuits

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: ATHENS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Biomedical research is the backbone of essential advances fueling public health and well-being, but graduate training in biomedical research is plagued by high attrition and deteriorating student well-being. The present research will address a critical source of influence on these issues, particularly among students who are underrepresented in biomedical fields: the mentoring relationships that biomedical graduate students experience with their research advisors. We propose to design and experimentally test the effectiveness of a low-touch and high-touch intervention that equips research advisors with the motivation and conflict management skills needed to improve their mentoring relationships, and examine how these interventions affect mentoring relationships and students’ career-related outcomes.

PI_NAMEs: DOLAN, ERIN L (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Address;Affect;Biomedical Research;career;comparison intervention;Conflict (Psychology);Control Groups;design;Deterioration;Disability status;doctoral student;Educational Intervention;effective intervention;Effectiveness;effectiveness evaluation;effectiveness testing;Equity;ethnic minority;experience;experimental study;Feedback;Field Reports;Gender;Goals;graduate student;Hour;Humanities;improved;Individual;Influentials;Intervention;intervention program;Investments;Light;low socioeconomic status;Mentors;Mentorship;Motivation;novel;Outcome;Personal Satisfaction;Persons;pilot test;prevent;Productivity;programs;Public Health;Publications;Publishing;racial minority;Randomized;Research;Resources;satisfaction;scale up;skills;skills training;Social Sciences;Source;Stressful Event;Students;success;Surveys;Testing;theories;Time;Touch sensation;Training;Training Programs;Underrepresented Populations;Underrepresented Students;Universities;Vertebral column;Work;Writing

PROJECT_TITLE: The IMPACT Study: Improving Mentorship Practice through Attributions and Conflict Training


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Narrative We propose to continue the Tissue Microenvironment (TiMe) Training Program at the University of Illinois at Urbana-Champaign. Focusing on three technological themes — bioengineering, imaging and sensing, and computational modeling and analytics — the program focuses on both intellectual and professional development of students. Building on the collaborative faculty, leading disciplinary expertise at Illinois, and extensive facilities and exceptional institutional support, this unique educational platform trains the next generation of interdisciplinary research leaders.

PI_NAMEs: BHARGAVA, ROHIT  (contact);GASKINS, REX

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Tissues;Training Programs

PROJECT_TITLE: Tissue microenvironment (TIMe) training program


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative There are significant hurdles in the way of investigators wishing to employ xenograft models of various hematopoietic cancers. In addition to the lack of sufficient numbers of robust, readily available xenograft models such as PDX, numerous technical challenges must be overcome to successfully perform xenograft experiments. Based on my extensive experience in the field, I have built a comprehensive resource, the Humanized Mouse Resource, to address these issues that is tailored to meet the needs of internal and external collaborators, particularly those with NCI funded projects.

PI_NAMEs: WUNDERLICH, MARK  (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: Address;Affect;Breeding;Carcinogenesis Mechanism;Cell model;Cells;Cellular Morphology;Childhood Leukemia;Communities;Detection;Development;Disease;drug development;drug discovery;Environment;expectation;experience;experimental study;Flow Cytometry;Funding;Gene Expression;Gene Expression Regulation;Genetic;Genomics;Hematologic Neoplasms;Hematopoiesis;Human;humanized mouse;immunodeficiency;Immunodeficient Mouse;improved;in vivo;Inbred Strain;innovation;insight;Institution;leukemia;Loss of Heterozygosity;Malignant Neoplasms;man;Methods;Modeling;Molecular;mouse model;Mouse Strains;Mus;Mutation;Nature;new therapeutic target;Patients;Phenotype;Proliferating;Protocols documentation;Recording of previous events;Research;Research Personnel;resistance mechanism;Resources;Sampling;Science;System;Technology;Therapeutic;Therapeutic Intervention;Transplantation;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Therapeutic insights through patient derived leukemia xenografts


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Penn ADRC Project Narrative The Penn ADRC is highly aligned with and will contribute to the National Alzheimer’s Project Act’s (NAPA) ambitious goal of effective prevention or treatment of Alzheimer’s Disease and Related Dementias (AD/ADRD) by 2025. To achieve this goal, the Penn ADRC will provide intellectual and physical infrastructure to support research and education across the continuum of normal aging to dementia with the goal of identifying the causes of and cures for AD/ADRD, with a particular focus on AD heterogeneity. The Center will contribute to transformative local efforts, but also will actively participate in broader national efforts, including many supported by the National Institute on Aging.

PI_NAMEs: WOLK, DAVID A (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Achievement;Address;African American population;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease related dementia;Alzheimer's disease risk;Autopsy;Biocompatible Materials;Bioinformatics;Biological Aging;Biological Markers;biomarker development;Caregivers;Caring;Cerebrovascular Disorders;Clinical;Clinical Data;Cognitive;cognitive testing;cohort;Collaborations;Communities;comorbidity;Data;data management;data sharing;Databases;Dedications;Degenerative Disorder;Dementia;Development;diagnostic biomarker;diagnostic strategy;digital;Disease;disease heterogeneity;Education;education research;effective therapy;empowerment;Environment;ethical, legal, and social implication;Frontotemporal Dementia;Funding;Genetic;Genomics;Goals;Heterogeneity;Histology;Image;Impairment;Infrastructure;Institution;International;Intervention;Late Onset Alzheimer Disease;Lewy Body Disease;Link;Measures;medical schools;Methodology;Methods;Mission;Modeling;Molecular Biology;molecular pathology;National Institute on Aging;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;neuropathology;next generation;normal aging;novel;older adult;outreach;Pathologic;Pathology;Patients;Pennsylvania;Personal Satisfaction;Phenotype;Plasma;precision medicine;Prevention;Process;Prognosis;programs;racial diversity;Recording of previous events;recruit;Research;Research Personnel;Research Support;Risk;social health determinants;sociodemographics;Techniques;Training;Training Programs;Underrepresented Minority;Universities;Validation;Vascular Diseases

PROJECT_TITLE: Penn Alzheimer's Disease Research Center (ADRC)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Applications Grants;Behavioral Research;Biocompatible Materials;brain health;career development;Caring;Charge;Clinical Research;Clinical Trials;Collaborations;Community Health Education;Community Outreach;Data;data dissemination;data sharing;Dementia;design;Development;Diagnosis;Discipline;Disease;disease heterogeneity;Early Onset Alzheimer Disease;Education;education research;Elderly;empowerment;Ensure;epidemiology study;Event;Faculty;Family;Feedback;Fostering;Genetic Diseases;Goals;Grant;Growth;Human Subject Research;improved;Individual;Infrastructure;innovation;Institution;International;Leadership;lectures;Link;meetings;member;Mission;Monitor;multidisciplinary;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;Neurosciences;next generation;normal aging;novel;operation;participant enrollment;Persons;Phenotype;Positioning Attribute;Postdoctoral Fellow;Procedures;Process;Productivity;programs;Reagent;Recommendation;Recruitment Activity;Reporting;repository;Research;Research Personnel;Research Training;Role;Science;Series;Students;success;Teacher Professional Development;Techniques;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative Survival outcomes for children, adolescents and young adults with osteosarcoma, the most common malignant bone tumor in this population have remained stagnant for over 3 decades and new approaches utilizing targeted therapies are needed in improve cure rates. In order to identify targeted therapies with highest potential to have clinical efficacy, a robust osteosarcoma preclinical drug screening program with the capacity to rapidly and efficiently screen numerous agents is needed. We propose to use genomic and proteomic profiling in molecularly characterized osteosarcoma patient-derived xenograft models to guide the selection and testing of targeted agents, including antibody-drug conjugates and inhibitors, in preclinical models of osteosarcoma.

PI_NAMEs: GORLICK, RICHARD G. (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Adolescence;Adolescent and Young Adult;Antibodies;Antibody-drug conjugates;arm;biomarker development;biomarker selection;CCNE1 gene;CD276 gene;CDK4 gene;Cell Line;chemotherapy;Child;Childhood;clinical development;clinical efficacy;clinical translation;Clinical Trials;clinically actionable;cohort;Complement;Control Groups;Cytotoxic Chemotherapy;Data;Development;Dimensions;Disease;disease heterogeneity;DNA Sequence Alteration;Drug Combinations;Drug Screening;effective therapy;efficacy evaluation;experience;experimental group;experimental study;Foundations;Future;genomic profiles;genomic profiling;Genomics;Goals;Heterogeneity;Human;implantation;improved;In complete remission;in vivo;in vivo evaluation;Incidence;inhibitor;Laboratories;Lead;Malignant - descriptor;Malignant Bone Neoplasm;Measures;Membrane Proteins;Mission;Modeling;Modernization;Molecular;molecular marker;Molecular Profiling;Molecular Target;Mus;New Agents;next generation;Normal tissue morphology;novel;novel strategies;Oncogenic;Osteosarcoma;partial response;Pathway interactions;patient derived xenograft model;patient population;Patient-Focused Outcomes;Patients;Pediatric Oncology Group;Pharmaceutical Preparations;Phase II Clinical Trials;Population;pre-clinical;Pre-Clinical Model;precision medicine;Preclinical Testing;preservation;primary bone cancer;Procedures;Progressive Disease;protein expression;Proteins;Proteomics;Research Proposals;Resources;response;Sampling;screening;screening program;Stable Disease;Surface;Surface Antigens;survival outcome;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Toxic effect;treatment response;tumor;tumorigenesis;Vision;Work;Xenograft procedure;young adult

PROJECT_TITLE: Genomically informed agent selection and testing in osteosarcoma patient-derived xenograft models


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Enteroviruses cause a variety of significant illnesses but the underlying disease mechanisms are largely unknown. We will investigate how enteroviral proteases impair normal cell functioning and contribute to disease development. Consistent with the NIH mission, these studies will reveal the mechanisms of enteroviral pathogenesis and inform the design of novel therapeutic strategies.

PI_NAMEs: SAEED, MOHSAN  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Biological Assay;Biology;candidate identification;Cell Culture Techniques;Cell Physiology;cell type;Cells;chromatin remodeling;clinically relevant;Cultured Cells;design;Development;Disease;Encephalitis;Enterovirus;Enterovirus Infections;Environment;Epithelial Cells;Eukaryotic Initiation Factors;Foundations;Gastroenteritis;Genes;Goals;Human Cell Line;human disease;human induced pluripotent stem cells;human pathogen;Immune;Immune signaling;Immunologic Monitoring;Impairment;Infection;innate immune function;innate immune pathways;Innate Immune Response;innovation;insight;Integration Host Factors;Interferons;intestinal epithelium;Investigation;Knock-out;Label;Learning;Life Cycle Stages;Maps;Mediating;Mesenchyme;Metabolism;Methodology;Mission;Molecular;Monitor;Myocarditis;N-terminal;Natural Immunity;Normal Cell;novel;novel therapeutic intervention;Organ;Pathogenesis;Pathway interactions;Peptide Hydrolases;peroxisome;Pneumonia;Predisposition;Preventive;Process;programs;protein transport;Proteins;Proteolysis;Publications;Reagent;real time monitoring;Regulation;Research;response;RNA Splicing;RNA Viruses;Role;Shapes;Signal Transduction;System;Testing;Therapeutic;tool;Translations;treatment strategy;United States National Institutes of Health;Variant;Viral;Viral Physiology;Virus;Virus Assembly;Virus Diseases;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Functional characterization of the enteroviral degradome

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PROJECT_TERMS: Achievement;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Attention;Autopsy;Awareness;base;Biological;Biological Markers;biomarker development;Brain;brain tissue;cardiovascular risk factor;Caring;Cerebrospinal Fluid;Cerebrovascular Disorders;Cerebrum;Classification;Classification Scheme;Clinical;Clinical Data;clinical diagnosis;clinical phenotype;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive reserve;cohort;Collaborations;comorbidity;Data;data integration;data management;Data Set;Dementia;Disease;disease heterogeneity;disorder risk;diverse data;DNA;Doctor of Philosophy;Early Onset Alzheimer Disease;Economic Factors;education research;Epigenetic Process;ethnoracial;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Genetic;Genetic Materials;Genomics;Goals;Heterogeneity;Image;imaging program;in vivo;Individual;Institution;International;Intervention Studies;Lewy Body Disease;Light;Link;Magnetic Resonance Imaging;Measures;Mechanics;Mission;molecular marker;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;Neurofibrillary Tangles;neuroimaging;neuropathology;next generation;normal aging;older adult;Onset of illness;outreach;Participant;Pathologic;Pathologist;Pathology;Persons;Phenotype;Plasma;Positron-Emission Tomography;pre-clinical;Process;protein TDP-43;recruit;Research;Research Personnel;research study;resilience;Risk;Role;Sampling;Senile Plaques;Site;social factors;social health determinants;sociodemographic factors;Source;synuclein;System;tau Proteins;Training;Validation;White Matter Hyperintensity

PROJECT_TITLE: Clinical Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE-RELEVANCE TO PUBLIC HEALTH Heart disease is a significant cause of morbidity and mortality in the U.S. This proposal will improve our understanding of adverse nervous system changes that occur in the setting of a heart attack and lead to life threating heart rhythms. The proposed mechanistic research studies have significant potential to develop new targets in the treatment of dangerous heart rhythms that cause sudden cardiac death and recurrent defibrillator shocks through modulation of nerves that supply the heart.

PI_NAMEs: VASEGHI, MARMAR  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acceleration;Acetylcholine;Angiotensin-Converting Enzyme Inhibitors;Animal Model;Animals;Anti-Arrhythmia Agents;Arrhythmia;Autonomic Pathways;Baroreflex;beta-adrenergic receptor;Bilateral;Brain Stem;Cardiac;Cardiac ablation;cardiac implant;Cardiovascular Diseases;Cervical;Chest;Chronic;Cicatrix;Clinical Trials;Dangerousness;Defibrillators;density;Development;Disease;Electrophysiology (science);Excision;Exercise;experience;Fiber;Functional disorder;Galanin;galanin receptor;Ganglia;Heart;Heart Diseases;Heart failure;heart rate variability;heart rhythm;hemodynamics;Hospitalization;improved;Infarction;insight;Interruption;interstitial;Knowledge;Lead;Life;Maps;Measurement;Measures;Mediating;Medical;Morbidity - disease rate;mortality;multi-electrode arrays;Muscle Cells;Myocardial Infarction;myocardial injury;Nerve;nerve supply;Nervous System;neural;Neuroeffector Junction;neuropeptide Y;Neuropeptides;neuroregulation;Neurostimulation procedures of spinal cord tissue;neurotransmission;new therapeutic target;Nociception;Norepinephrine;novel;Patients;prevent;Public Health;Quality of life;Recurrence;research study;Resiniferatoxin;Risk;Role;Shock;Signal Transduction;Spinal Cord;sudden cardiac death;Sympathectomy;Sympathetic Ganglia;Tachyarrhythmias;targeted treatment;Testing;Time;Travel;Ventricular;Ventricular Arrhythmia;Withdrawal

PROJECT_TITLE: Ventricular arrhythmias and mechanisms of parasympathetic dysfunction following myocardial infarction

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Chronic Pain;Clinical Research;Eye Disease and Disorders of Vision;Headaches;Migraine;Neurosciences;Pain Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Concussion afflicts 1 in 5 youths in the United States. Headache is one of the most common and disabling symptoms following concussion, affecting 25% of youth for longer than 1 month, yet there are no established recommendations on when or how to treat post-traumatic headache. This project will investigate the biological processes of migraine in youth following concussion to guide the timing and types of treatments used in post- traumatic headache.

PI_NAMEs: PATTERSON GENTILE, CARLYN ANNE (contact)

PROGRAM_OFFICER_NAME: SYPEK, ELIZABETH IRENE

PROJECT_TERMS: Adult;Affect;Age;Animal Model;Biological Markers;Biological Process;biomarker development;Blood;Brain Concussion;Brain Stem;Calcitonin Gene-Related Peptide;candidate marker;career development;Caring;Child;Childhood;Chronic;Clinical;clinical candidate;clinical infrastructure;Clinical Research;Clinical Trials;common symptom;comparison control;cytokine;Data;Dedications;Development;disability;disabling symptom;Doctor of Philosophy;early detection biomarkers;Early identification;Electrophysiology (science);Enrollment;Environment;experience;frontier;Functional disorder;Future;Goals;Grant;Guidelines;Headache;Headache Disorders;Health;Hour;improved;Individual;Inflammatory;Infrastructure;Interleukin-6;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Migraine;Mind;Neurons;Neurosciences;novel;Participant;Pathogenesis;Pathway interactions;Patients;Pediatric Hospitals;Pennsylvania;Peripheral;peripheral blood;Persons;Philadelphia;Photophobia;Physicians;Play;Positioning Attribute;Post-Traumatic Headaches;predictive marker;Principal Component Analysis;Prognostic Marker;programs;Property;prophylactic;Recommendation;Recovery;recruit;Reporting;Research;Research Design;Research Infrastructure;Research Personnel;Resolution;Risk;Role;Scientist;signal processing;Signal Transduction;skills;Specialist;Symptoms;System;Techniques;Testing;Time;TNF gene;Training;Traumatic Brain Injury;Trigeminal Nuclei;Trigeminal System;United States;Universities;Vision;Visual;Visual Cortex;Visual evoked cortical potential;Visual System;Youth

PROJECT_TITLE: Trigeminovascular sensitization in post-traumatic headache: electrophysiologic and blood biomarkers in youth

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Project Narrative In heart (between beats), abnormal intracellular calcium release may trigger arrhythmias that can lead to sudden death. This project defines why this abnormal calcium release occurs and explores therapeutic strategies to make it less likely to occur. And thus, advance our understanding cardiac arrhythmia prevention and treatment.

PI_NAMEs: FILL, MICHAEL  (contact);GILLESPIE, DIRK

PROJECT_TERMS: Address;analog;Arrhythmia;Behavior;Black Box;Calcium;Calsequestrin;carvedilol;Catalogs;Catecholaminergic Polymorphic Ventricular Tachycardia;Cells;clinically relevant;Complex;Data;Diastole;Drug Targeting;Event;Failure;falls;Feedback;Foundations;Geometry;Heart;Housing;Human;Hybrids;Individual;innovation;insight;Knowledge;Measures;Mediating;Modality;Modeling;nanoscale;novel;novel strategies;operation;Outcome;Pathologic;Physiological;Pilot Projects;prevent;Prevention;Process;receptor function;receptor structure function;recruit;Regulation;Resistance;Risk;Role;Ryanodine Receptor Calcium Release Channel;Sarcoplasmic Reticulum;simulation;Site;spatiotemporal;Specific qualifier value;Stress;sudden cardiac death;Sudden Death;Sum;synergism;Technology;Testing;Therapeutic;Ventricular;Ventricular Tachycardia;Work

PROJECT_TITLE: Collective Ryanodine Receptor Operation at Release Sites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


PI_NAMEs: XIE, SHARON XIANGWEN (contact)

PROJECT_TERMS: Address;Adult;African American population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid beta-Protein;Big Data;Bioinformatics;Biological Markers;Biometry;Clinical;Cognitive;Collaborations;comorbidity;Complex;Computer software;Computer Systems;Data;Data Analyses;Data Display;data management;data quality;Data Set;data sharing;Databases;Dementia;design;Development;Disease;Doctor of Philosophy;education research;Funding;Generations;Genetic;Genomics;Goals;Heterogeneity;heterogenous data;Image;Link;Liquid substance;Longitudinal Studies;Manuscripts;Measures;medical schools;Methodology;Methods;mild cognitive impairment;multimodality;National Institute on Aging;Neurodegenerative Disorders;neuroimaging;neuropathology;operation;Pathology;patient oriented;Pennsylvania;Phenotype;Play;Preparation;Procedures;programs;Publications;Quality Control;Questionnaire Designs;Reporting;Research;Research Design;Research Personnel;Research Support;Role;Sample Size;Security;Services;Site;sociodemographic factors;support network;tau Proteins;Training;Universities;Work

PROJECT_TITLE: Data Management and Statistical Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE The proposed project seeks to understand the cell-type specific role of lncRNAs in the regulation of neuroimmune-related gene expression and behavior(s) for excessive ethanol exposure. We will use cutting- edge approaches such gene mutagenesis (i.e., CRISPR) and high-throughput sequencing to determine novel molecular mechanisms associated with the development of Alcohol Use Disorder (AUD).

PI_NAMEs: FARRIS, SEAN P (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Ablation;Acute;Address;Adult;Affect;alcohol behavior;Alcohol consumption;alcohol effect;alcohol exposure;alcohol sensitivity;alcohol use disorder;Alternative Splicing;Animal Model;Animals;Astrocytes;Behavior;behavior test;behavioral phenotyping;Biological Models;Biological Process;Brain region;Cell Physiology;cell type;Cells;Central Nervous System;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Code;comorbidity;conditional knockout;CRISPR screen;CRISPR/Cas technology;Data;Development;Disease;drinking behavior;Ensure;Environment;Ethanol;Ethanol dependence;Exhibits;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genome editing;Genomic approach;Health;High-Throughput Nucleotide Sequencing;Human;Immune response;improved;In Vitro;in vivo;in vivo Model;Individual;Interferons;Knock-out;Knockout Mice;Knowledge;Length;Literature;LoxP-flanked allele;MALAT1 gene;mammalian genome;Mediating;Modernization;Molecular;Morphology;Mus;Mutagenesis;nanopore;Neurobiology;Neuroglia;Neuroimmune;Neuroimmune system;neuroinflammation;Neuronal Plasticity;Neurons;neuropsychiatric disorder;novel;Nucleotides;Pathogenesis;Pathologic;Pathway interactions;Pharmacotherapy;Play;Protein Splicing;Proteins;rational design;Regulation;Regulator Genes;Reproducibility;Research Proposals;response;RNA;Role;single cell sequencing;single-cell RNA sequencing;socioeconomics;Stimulus;System;Testing;Tissues;Transcript;transcriptome;transcriptome sequencing;Untranslated RNA

PROJECT_TITLE: LNCRNA REGULATION OF GENE EXPRESSION & BEHAVIOR


PI_NAMEs: LEE, EDWARD BYUNG-HA (contact)

PROJECT_TERMS: age related neurodegeneration;aging brain;aging related;alpha synuclein;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid beta-Protein;Archives;Autopsy;Basic Science;Biological;Blood Vessels;Brain;Cells;Central Nervous System;Cerebrovascular Disorders;Classification;Clinical;clinical phenotype;Cognitive;Collaborations;comorbidity;Complement;Data;data management;Databases;Dedications;demented;Dementia;Dementia with Lewy Bodies;Deposition;Diagnosis;digital;Disease;Doctor of Medicine;Doctor of Philosophy;Documentation;Education;education research;Elderly;Extracellular Space;Fostering;Freezing;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;genetic analysis;genome-wide;Goals;Heterogeneity;hippocampal sclerosis;Histology;Histopathology;Human;Impaired cognition;Individual;Lesion;Lewy Bodies;Libraries;Literature;Magnetic Resonance Imaging;Mission;Monitor;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;neuropathology;Neuropil;nonalzheimer dementia;normal aging;Pathologic;Pathology;Peptides;Population;protein aggregation;protein TDP-43;Qualifying;Research;Research Personnel;research study;Research Support;Resolution;Sampling;Secure;Senile Plaques;Standardization;synucleinopathy;tau Proteins;Tissue Banks;tissue fixing;transmission process;Work

PROJECT_TITLE: Neuropathology Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health;Suicide

PHR: PROJECT NARRATIVE While an expanding body of theory-driven research has consistently shown how factors related to structural sexual minority stigma may drive sexual orientation-based mental health disparities, US-based evidence has been hampered by single stand-alone indicators of structural stigma, leading to important risks for confounding bias. Existing public health datasets have not independently been able to facilitate research that could fully account for such confounding bias, leading to distorted results. Together with newly developed comprehensive structural sexual minority stigma indices, the proposed harmonization and integration of large US public health datasets (i.e., NHIS, Add Health, YRBS, and ABCD) will enable advanced cross-sectional and longitudinal multilevel models to address the risks for confounding that currently bias evidence on how structural sexual minority stigma across both macro (i.e., state) and exo (i.e., county) levels drive and sustain sexual orientation- based disparities in depressive symptoms and suicidality outcomes.

PI_NAMEs: VAN DER STAR, ARJAN  (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Address;Advocacy;Age;Attitude;Automobile Driving;Climate;combat;Complex;Country;County;Data;data harmonization;data integration;Data Pooling;Data Set;depressive symptoms;Development;Disparity;District of Columbia;European;evidence base;Exposure to;Feeling suicidal;Gender;gender diverse;Generations;Geography;harassment;hate crimes;health disparity;health equity;health inequalities;Health Surveys;Heterosexuals;improved;indexing;Individual;Inequity;Institutionalization;internalized stigma;Laws;Legal;Libido;Life Cycle Stages;lifetime risk;Link;Marriage;Measures;Mediating;Mental Depression;Mental Health;Modeling;multilevel analysis;National Longitudinal Survey of Adolescent to Adult Health;Neighborhoods;novel;Outcome;Personal Satisfaction;Persons;Policies;Politics;Population;Prevalence;preventive intervention;Public Health;Random Allocation;Reporting;Research;Risk;same-sex marriage;Sample Size;Schools;Sex Orientation;sexual minority;sexual minority group;sexual minority status;Sexuality;Shapes;social stigma;Societies;Stigmatization;structural determinants;suicidal;suicidal behavior;Suicide attempt;System;Testing;theories;Therapeutic Intervention;Urbanization;US State;Victimization

PROJECT_TITLE: The Socioecology of Sexual Minority Stigma: Data Harmonization to Address Confounding Bias and Investigate Cross-Level MentalHealth Effects


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Arthritis;Autoimmune Disease;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Rheumatoid Arthritis

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE While several research studies have demonstrated that inflammation plays an important role in the risk of dementia, the knowledge of how this risk develops and how to reduce it is lacking. Understanding the effect of chronic systemic inflammation, and therapies used to suppress it, on the development of dementia in patients with rheumatoid arthritis (RA) is crucial, as it can highlight opportunities for prevention and treatment of dementia in RA and beyond. In this proposal, using existing data resources of the Rochester Epidemiology Project and the Mayo Clinic Study of Aging, we will examine the risk and timing of cognitive decline and dementia in patients with RA, depending upon the level of inflammation and the use of medications for RA.

PI_NAMEs: MYASOEDOVA, ELENA  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Address;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Anti-Rheumatic Agents;Apolipoprotein E;Autoimmune;Autoimmunity;Biological Products;Brain;Brain Pathology;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;cerebrovascular pathology;Characteristics;Chronic;Clinic;Clinical;Cognition;Cognitive;cognitive change;cognitive function;cohort;comorbidity;Data;data resource;Data Set;Dementia;dementia risk;demographics;Deterioration;Development;Disease;disease model;Education;Epidemiology;Evolution;Exposure to;Funding;Future;General Population;genetic risk factor;immunomodulatory therapies;Impaired cognition;Individual;Inflammation;Inflammatory;inflammatory marker;Infrastructure;insight;Knowledge;Late Onset Alzheimer Disease;lifetime risk;Longitudinal Studies;magnetic resonance imaging biomarker;Measures;Medical Record Linkage;Mental Depression;Modeling;modifiable risk;Nerve Degeneration;neuroimaging marker;Neuropsychology;novel;Obesity;Participant;Pathogenesis;Patients;Persons;Pharmaceutical Preparations;Phenotype;Play;population based;Prevention;Prevention strategy;prognostication;protective effect;Proteins;prototype;radiological imaging;Research;research study;Resources;response;Rheumatism;Rheumatoid Arthritis;Risk;Risk Factors;Risk Reduction;Role;secondary analysis;Series;Serology;sex;Smoking;Socioeconomic Status;System;systemic inflammatory response;therapeutic target;Time

PROJECT_TITLE: Role of Systemic Inflammation in Cognitive Decline: Rheumatoid Arthritis as a Prototype

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Although dengue virus infection often manifests as an asymptomatic or mildly symptomatic disease, approximately 10% of dengue-infected patients experience more severe forms of symptomatic disease, characterized by life-threatening complications. In recent studies, we demonstrated that dengue disease susceptibility and severity is associated with elevated levels of specific antibody glycoforms, which engage and activate specific leukocytes, resulting in aberrant immune activation and disease pathogenesis. The proposed studies aim to define the mechanisms by which these glycoforms are generated during dengue infection, significantly advancing our understanding of the mechanisms of dengue disease pathogenesis.

PI_NAMEs: BOURNAZOS, STYLIANOS  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Affinity;Antibodies;Antibody Repertoire;Antibody-Dependent Enhancement;Antigenic Specificity;Area;arthropod-borne;Autoimmunity;Automobile Driving;Biological;Cambodia;Cellular Assay;chemokine;Clinical;Complex;Coupled;COVID-19;cytokine;Dengue;Dengue Hemorrhagic Fever;Dengue Infection;Dengue Shock Syndrome;Dengue Virus;Development;Disease;Disease susceptibility;epidemiology study;Event;Exhibits;experience;Fc domain;Funding;Heterogeneity;High Prevalence;Human;Immune;immune activation;Immune response;Immune System Diseases;Immunoglobulin G;immunological status;In Vitro;in vivo;in vivo Model;Infection;infection risk;Inflammatory;insight;Leukocytes;Life;Macrophage;Macrophage Activation;Mediating;Memory;Modeling;Morbidity - disease rate;mortality;Mothers;mouse model;Mouse Strains;Myeloid Cells;Newborn Infant;novel;Outcome;Pathogenesis;pathogenic virus;Pathogenicity;Pathway interactions;Patients;permissiveness;Persons;Plasmablast;Polysaccharides;Population;Predisposition;Prognostic Factor;Public Health;receptor;Recording of previous events;Recurrence;response;Risk;Risk Factors;Role;Serum;severe dengue;Severities;Severity of illness;Spleen;Symptoms;targeted treatment;Therapeutic;Transcription Alteration;transcriptome;Vaccination;Virus Diseases;Virus Replication

PROJECT_TITLE: Mechanisms of Antibody-Dependent Enhancement of Dengue Disease

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Social Determinants of Health

PI_NAMEs: KARLAWISH, JASON H (contact)

PROJECT_TERMS: Address;African American;Altruism;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Attitude;Biological Markers;Black American;brain health;care delivery;Caregivers;caregiving;Caring;Clinical;Clinical Trials;Cognitive aging;cohort;Collaborations;Communication;Communities;community collaboration;community organizations;community partners;comorbidity;coping;Data;data management;Dedications;Dementia;Development;Diagnosis;Disease;disease heterogeneity;Disparity;diversity and inclusion;Doctor of Medicine;Doctor of Philosophy;economic disparity;education research;Effectiveness;empowerment;equity, diversity, and inclusion;evidence base;experience;Family;Fostering;Functional disorder;gene discovery;Genes;Genetic Markers;Genetic Materials;Genomics;Goals;Heterogeneity;Humanities;improved;innovation;Internships;Knowledge;Language;late life;Laws;Learning;Measures;Medicine;Memory;Methods;Mission;Modeling;Neurodegenerative Disorders;neuroimaging;neuropathology;next generation;outreach;Participant;Patients;Pennsylvania;Personal Satisfaction;Persons;Philadelphia;Physicians;Population;pre-clinical;prevent;programs;Protocols documentation;Public Health;Public Policy;recruit;recruitment science;Registered nurse;Research;Research Ethics;Research Personnel;Risk;Shapes;skills;social determinants;social disparities;social health determinants;social stigma;Structure;Technology;Time;Training;Translating;Trust;Universities;Work

PROJECT_TITLE: Outreach, Recruitment and Engagement Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative The ultimate goal of this project is to test in animals (mice and monkeys) antibodies that we have previously identified that have broad and potent activity against most HIV viruses for their ability to prevent and treat HIV infection. We hope that these antibodies can eventually be used to prevent or treat HIV infection in humans.

PI_NAMEs: SAJADI, MOHAMMAD MOHSENI (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Adherence;AIDS prevention;Animal Model;Animals;Anti-Retroviral Agents;Anti-viral Agents;Antibodies;Antibody Therapy;Antibody-mediated protection;Antigens;antiretroviral therapy;Binding Sites;CD34 gene;CD4 Antigens;Cell Nucleus;Cells;Characteristics;Chronic;clinical application;clinical development;Clinical Trials;Combined Modality Therapy;Data;Development;Disadvantaged;Disease Progression;Dose;Drug Combinations;Drug or chemical Tissue Distribution;Engineering;Ensure;Exhibits;experimental study;Exposure to;Face;Failure;Family;Fc domain;Generations;genotoxicity;Goals;Half-Life;HIV;HIV Antibodies;HIV envelope protein;HIV Infections;HIV therapy;HIV-1;Human;humanized mouse;immunodeficiency;Immunoglobulin G;In Vitro;in vivo;Infection;interest;Lead;Logistics;Macaca mulatta;Methods;Modality;Modeling;Modification;Monkeys;mouse model;Mus;Mutation;neonatal Fc receptor;neutralizing antibody;nonhuman primate;novel;Passive Immunization;Pharmaceutical Preparations;Plasma;Polysaccharides;Positioning Attribute;pre-exposure prophylaxis;prevent;Prevention;Preventive;prophylactic;Prophylactic treatment;protective efficacy;reconstitution;recruit;Resistance;response;Risk;side effect;simian human immunodeficiency virus;SIV;Standardization;stem;stem cells;success;Tenofovir;Testing;Therapeutic;Therapeutic Effect;Transgenic Mice;transmission process;Treatment Efficacy;Treatment Protocols;United States National Institutes of Health;Variant;Viral Load result;Viremia;Virus;Virus Replication

PROJECT_TITLE: Novel bNAB-based treatment and prevention of HIV-1

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE There are marked inequities in HIV pre-exposure prophylaxis (PrEP) provision in the U.S., with Black individuals comprising only 10% of PrEP users, underscoring the urgent need for innovative research to optimize PrEP delivery for Black adults of all genders and sexual orientations. The proposed research will identify key determinants of PrEP delivery (Aim 1); develop a multifaceted implementation strategy to accelerate equitable PrEP delivery for Black primary care patients (Aim 2); and conduct a 12-month two- arm pilot to evaluate strategy feasibility and acceptability at four primary care practices in Philadelphia (Aim 3). Given the critical need to achieve equitable PrEP care continuum outcomes, this research will have significant public health implications.

PI_NAMEs: WATSON, DOVIE  (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Administrator;Adult;AIDS prevention;arm;Award;behavior change;behavioral and social science;black patient;Black Populations;Black race;Board Certification;care outcomes;career;Caring;cisgender;Client;Collaborations;Communicable Diseases;Communities;community engaged research;Consolidated Framework for Implementation Research;Continuity of Patient Care;design;Development;effectiveness/implementation trial;Environment;Epidemic;Equity;Evaluation;evidence base;Evidence based practice;experimental arm;Foundations;Funding;Gender;gender diversity;Goals;Heterosexuals;HIV;implementation design;implementation determinants;implementation evaluation;implementation science;implementation strategy;improved;Incidence;Individual;Inequity;innovation;interdisciplinary approach;Interview;Investments;K-Series Research Career Programs;Knowledge;Leadership;Lesbian Gay Bisexual Transgender Queer;Maps;Measures;Medical;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;Modality;multidisciplinary;National Institute of Mental Health;National Institute on Minority Health and Health Disparities;next generation;novel;Outcome;Patients;Philadelphia;Physicians;pilot trial;pleasure;Population;Positioning Attribute;pre-exposure prophylaxis;Preventive service;primary care patient;primary care practice;primary care services;primary care setting;Provider;provider behavior;Public Health;Qualitative Research;racism;Research;Research Design;Research Methodology;Research Personnel;Research Priority;Resources;Scientist;Sex Orientation;Sexism;Sexual Health;Sexuality;social cognitive theory;Social Environment;social science research;Social Sciences;social stigma;Surveys;Testing;theories;Training;trial design;United States;Work

PROJECT_TITLE: Accelerating Equitable PrEP Delivery for Black Adults in Primary Care Settings: Development and Testing of A Practice-Level Multifaceted Implementation Strategy

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative: We seek to adapt a rapid, sensitive biosensing device that can identify specific gas molecules for the screening and diagnosis of twenty high-burden human diseases through the `scent' they emanate through the skin. Ultimately, we envision this platform can be applied to diagnosis of many other diseases, reducing diagnostic delays and allowing early administration of appropriate therapies to improve clinical outcomes in patients with these diseases.

PI_NAMEs: KOO, SOPHIA  (contact)

PROGRAM_OFFICER_NAME: CROUCHER, LEAH TOLOSA

PROJECT_TERMS: Address;Adoption;Animals;Biological;Biological Assay;Biosensing Techniques;Blinded;case control;Characteristics;Clinical;Communicable Diseases;comorbidity;design;Detection;detection limit;Development;Devices;Diagnosis;Diagnostic;Diagnostic Equipment;diagnostic strategy;Diagnostic tests;diagnostic tool;diagnostic value;Disease;disease diagnosis;Enrollment;Ensure;Environmental Risk Factor;Evaluation;Functional disorder;Gas Chromatography;Gases;Human;human disease;improved;Individual;Inflammatory;Influenza;machine learning method;Malignant - descriptor;meetings;Mental disorders;Metabolic;Metabolism;Monitor;Morbidity - disease rate;Nervous System Disorder;novel;Olfactory Pathways;Outcome;Patients;point of care;Population;portability;Process;rapid detection;Reproducibility;Research Design;Sampling;screening;Skin;skin organogenesis;Smell Perception;Source;Specificity;Spectrometry;Standardization;Study Subject;Technology;Testing;Therapeutic;Time;Training;Translating;volatile organic compound;Volatilization;wearable device;wearable sensor technology;Work

PROJECT_TITLE: A Novel Device for Rapid and Noninvasive Volatile Metabolite-based Screening and Diagnosis of Multiple Disease States


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: CHEN-PLOTKIN, ALICE S (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Area;assay development;Autopsy;Biochemical;Biological Assay;Biological Markers;biomarker validation;Blood;Blood specimen;Blood Vessels;Cessation of life;Cholesterol;Classification;Classification Scheme;Clinical;clinical heterogeneity;clinical phenotype;Collaborations;Collection;Communities;Consultations;Data;Dementia;Development;disorder risk;Doctor of Philosophy;education research;feasibility testing;Fostering;Genomics;Glycosylated hemoglobin A;Goals;Homocysteine;Image;imaging biomarker;Individual;Interleukin-6;Investigation;Ligands;Light;Literature;Magnetic Resonance Imaging;Measures;Molecular;Molecular Diagnosis;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;neurofilament;neuroimaging;neuropathology;Normal Range;Participant;Pathology;peer;Pennsylvania;Plasma;Positron-Emission Tomography;Process;Protocols documentation;Reporting;Research;Research Personnel;Risk;Sampling;Scheme;Site;structural imaging;tau Proteins;tau-1;Testing;Training;Translational Research;Universities;vascular contributions;Vascular Diseases;Visit

PROJECT_TITLE: Biomarker Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: VAN DEERLIN, VIVIANNA M (contact)

PROJECT_TERMS: Advisory Committees;African American population;Age;age acceleration;aging brain;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Autopsy;biobank;Bioinformatics;biological age;Biological Markers;Blood;Brain;brain tissue;C9ORF72;career;Cerebrovascular Disorders;Chronology;Clinical;Clinical Trials;cohort;Cohort Studies;Collaborations;Collection;Communities;Complex;Counseling;Data;data management;data sharing;Databases;Dedications;Deposition;Disease;disease heterogeneity;disorder risk;DNA;DNA Library;DNA Methylation;DNA-Binding Proteins;Doctor of Philosophy;Education;education research;Ensure;epigenetic clock;epigenetic marker;Epigenetic Process;exome;Faculty;familial Alzheimer disease;Family;Family member;Funding;Genes;Genetic;genetic analysis;genetic association;Genetic Counseling;genetic counselor;genetic variant;Genome;genome-wide;Genomics;Genotype;Goals;Hereditary Disease;Heterogeneity;improved;Inherited;innovation;life span;Longevity;Measurement;Measures;member;Mission;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuropathology;novel therapeutics;Nucleic Acids;Onset of illness;outreach;Participant;Pathogenicity;Pathologic;Pathology;Patients;Pennsylvania;Play;polygenic risk score;Population;Population Heterogeneity;presenilin-1;Process;protein TDP-43;Quality Control;Recording of previous events;recruit;Research;Research Personnel;resilience;Resistance;Resources;Risk;Role;Sampling;Scientist;segregation;Services;Severity of illness;statistics;tau Proteins;Training;trait;Trans-Omics for Precision Medicine;Universities;Variant

PROJECT_TITLE: Genomics Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Rare Diseases

ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE We aim to determine the molecular requirements for healthy skeletal muscle function, in order to pave the way for discovery and design of more effective therapies for muscle disease and weakness. Our work will answer crucial questions about how the protein myosin-binding protein C (MyBP-C), a cause of distal arthrogryposis, functions in skeletal muscle, using reporter probes to visualize dynamic protein structures in contracting muscle cells. This research will greatly improve the human health prospects for understanding disease by determining effects of disease mutations and developing tools that can be used to discover novel treatments.

PI_NAMEs: COLSON, BRETT A (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acceleration;Actins;Actomyosin;Address;Affect;Anisotropy;Arthrogryposis;Artificial skin;Binding;Biological Assay;biophysical tools;Cardiac Myosins;Contracts;Contracture;Cyclic AMP-Dependent Protein Kinases;Deceleration;design;Development;Disease;Distal;effective therapy;Equilibrium;Evaluation;experimental study;Fiber;Fluorescence;Fluorescence Resonance Energy Transfer;Frequencies;Gel;Genes;Health;Human;Hypertrophic Cardiomyopathy;improved;In Situ;In Vitro;in vivo;innovation;Joints;Kinetics;Knock-out;Knockout Mice;Knowledge;Label;Length;Live Birth;Lower Extremity;Mass Spectrum Analysis;Measures;Mediating;Medical;Microfilaments;Molecular;Molecular Conformation;Monitor;mouse model;Mus;Muscle;Muscle Cells;Muscle Fibers;Muscle function;Muscle Proteins;Muscle Weakness;mutant;Mutant Strains Mice;Mutation;Myocardial;Myopathy;Myosin ATPase;myosin-binding protein C;N-terminal;Nonmuscle Myosin Type IIA;novel;novel therapeutics;Outcome;Pathogenicity;Performance;Permeability;Phosphoproteins;phosphorescence;Phosphorylation;Physiological;Positioning Attribute;Post-Translational Protein Processing;prevent;Protein Dynamics;Protein Isoforms;protein structure;Proteins;Publishing;Recombinants;Regulation;Reporter;Reporting;Research;Resolution;RNA Splicing;Role;Sampling;Sarcomeres;sensor;Site;skeletal;Skeletal Muscle;Slide;spectroscopic data;Stains;Structure;Structure-Activity Relationship;Testing;Therapeutic;Thick Filament;Thin Filament;Time;time use;tool;Tropomyosin;Upper Extremity;Variant;Visualization;Work

PROJECT_TITLE: Skeletal Myosin-Binding Protein C Regulation and Structural Dynamics

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE This training program is designed to address the significant and costly public health problem of alcohol use disorder by training postdoctoral biomedical, biobehavioral, health care, and other public health scientists to conduct alcohol intervention research. Our program draws on many scientific disciplines, including biological sciences, epidemiology and etiology, prevention, clinical, and public health research, and emphasizes multidisciplinary approaches to achieving innovations in alcohol research. Cutting-edge training of the next generation of alcohol researchers has the potential to accelerate the pace of science in developing effective alcohol treatments.

PI_NAMEs: MIRANDA, ROBERT  (contact);MONTI, PETER M.

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: alcohol intervention;Research Training;Treatment outcome

PROJECT_TITLE: Alcohol Intervention Treatment Outcome Research Training


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: DETRE, JOHN A (contact)

PROJECT_TERMS: Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Angiography;Autopsy;Biological;Biological Markers;biomarker development;Blood Vessels;Brain;brain behavior;Brain imaging;brain tissue;Cerebral hemisphere;Clinical;clinical center;Clinical Research;cohort;Collaborations;Consensus;Data;data infrastructure;data integration;data management;Data Provenance;data sharing;Databases;Development;digital;digital pathology;Dimensions;Disease;Disease Progression;Doctor of Medicine;Doctor of Philosophy;education research;Evaluation;flexibility;Functional Imaging;Genetic;Genomics;Heterogeneity;Histopathology;Image;Image Analysis;image guided;imaging informatics;imaging study;in vivo;Incidence;informatics infrastructure;Infrastructure;insight;Institution;Intervention;ischemic lesion;Link;Magnetic Resonance Imaging;Maps;Measures;Metadata;method development;Methods;Modality;Molecular;molecular imaging;Monitor;morphometry;MRI Scans;multimodality;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;neuroinflammation;neuropathology;neurovascular;novel;Optical Coherence Tomography;outreach;Participant;Pathology;perfusion imaging;Phenotype;Plasma;Positron-Emission Tomography;pre-clinical;Procedures;Process;Protocols documentation;radioligand;recruit;Reproducibility;Research;Research Personnel;Research Subjects;Resources;Retina;retinal imaging;Risk;Sampling;Scanning;Scientist;Slide;Specificity;Staging;statistics;structural imaging;Structure;tau Proteins;Tissues;Tracer;Training and Education;Translations;Universities;Update;Validation;Washington

PROJECT_TITLE: Neuroimaging Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Magnetic Resonance Imaging (MRI) has many advantages over other imaging methods, but MRI is slow. Addi- tional developments are required to shorten the scan time, improve patient comfort, reduce the use of sedation for imaging children, and improve image quality. In this project, we will develop faster and more accurate methods for MRI. These efforts should lead to signiﬁcant improvements in the diagnosis of different diseases, so that patients may beneﬁt from appropriate treatment.

PI_NAMEs: AHMAD, RIZWAN  (contact);SCHNITER, PHILIP

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;4D MRI;Acceleration;Address;Adoption;Adult;Algorithms;Anesthesia procedures;Architecture;Awareness;Brain;Brain imaging;Brain Neoplasms;Breathing;Cardiac;cardiovascular imaging;Child;Childhood;Clinical;computer framework;convolutional neural network;cost;Data;data acquisition;data space;deep learning;denoising;design;Development;Diagnosis;diagnostic value;Disease;Evaluation;Exhibits;Formulation;Goals;Headache;Heart;Heart Diseases;heart imaging;high dimensionality;Image;image reconstruction;Imaging Device;imaging modality;Immune;improved;Investigation;Learning;Magnetic Resonance Imaging;Maps;Methods;Modeling;Motion;musculoskeletal imaging;Network-based;neural network architecture;novel;Patients;Pattern;pediatric patients;Performance;Phase;Physics;Play;Predisposition;Process;prospective;Pythons;real-time images;reconstruction;Recovery;repository;Rest;Sampling;Scanning;Sedation procedure;Speed;Structure;Techniques;Technology;Testing;Time;Training;training data;Variant;Work

PROJECT_TITLE: A comprehensive deep learning framework for MRI reconstruction

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Surgical resection is the only curative therapy for patients with pancreatic ductal adenocarcinoma. However, only 15-20% of pancreatic cancer patients have resectable disease at diagnosis. For patients with borderline resectable tumors, targeted neoadjuvant therapies can downstage the tumor and enable surgical resection; however, these therapies would be more useful if clinicians had real-time information regarding patient response. To inform therapeutic decisions, we plan to establish shear modulus and vascular perfusion as imaging biomarkers for assessing patient response to neoadjuvant therapy, which should improve the treatment of pancreatic cancer patients.

PI_NAMEs: DOYLEY, MARVIN M (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Address;Aftercare;Anatomy;Assessment tool;Blood Vessels;Cells;Characteristics;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinical;Clinical Data;Clinical Research;contrast enhanced;Curative Surgery;curative treatments;Data;density;Development;Diagnosis;Diagnostic Imaging;Disease;Distal;Distant Metastasis;Drug Delivery Systems;effective therapy;elastography;Eligibility Determination;Endoscopic Ultrasonography;Excision;experience;fighting;flexibility;Fluorescence;gemcitabine;Geometry;Histologic;Human;human disease;Hybrids;Hypoxia;Image;imaging biomarker;Imaging Device;imaging system;Imaging Techniques;Immune;Immunofluorescence Immunologic;Immunology;improved;in vivo;Indocyanine Green;innovation;Intervention;Interventional Imaging;Knowledge;Love;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Measures;Metastatic Neoplasm to the Liver;Modulus;mouse model;Mus;Neoadjuvant Therapy;Neoplasm Metastasis;novel;Oncology;Operative Surgical Procedures;Optics;pancreas imaging;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathologic;Pathology;patient response;patient subsets;Patients;Perfusion;perfusion imaging;Phenotype;pre-clinical;Pre-Clinical Model;preclinical study;pressure;Qualifying;Radiation therapy;Radiology Specialty;Recurrence;Research;Resectable;Resistance;Resources;response;statistics;Structure;Surrogate Markers;Survival Rate;Techniques;Technology;Testing;Therapeutic;Therapeutic Effect;Time;Tissues;tomography;tool;Tracer;Translating;Treatment Efficacy;Treatment Protocols;treatment response;tumor;tumor diagnostic;Tumor Markers;tumor microenvironment;ultrasound;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Surrogate biomarkers for assessing changes in pancreatic cancer tumor microenvironment

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Address;Affect;African American;Alzheimer's Disease;Alzheimer's disease related dementia;Attention;Basic Science;Bioinformatics;Biological Markers;Biology;Black American;career;career life balance;Categories;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;Cognitive;Collaborations;collaborative approach;Computational Science;Creativeness;Data;Dedications;design;Diagnosis;Discipline;Disease;diversity and inclusion;Doctor of Philosophy;drug discovery;education research;epidemiology study;Ethics;Evaluation;experience;Faculty;Family;Fostering;Functional disorder;Genetic;Geriatrics;Goals;graduate student;Heterogeneity;improved;Individual;Informatics;instructor;interdisciplinary approach;interest;Knowledge;Laboratories;Lead;Leadership;Link;member;Memory;Mentors;Methodology;Methods;Minority Groups;Mission;Molecular;Molecular Biology;multidisciplinary;Neurodegenerative Disorders;Neurologist;Neurology;neuropathology;next generation;novel;outreach;Patient Care;Patients;Pennsylvania;Persons;Postdoctoral Fellow;prevent;professor;programs;Psychiatry;Radiology Specialty;recruit;Research;Research Design;Research Personnel;Residencies;responsible research conduct;Scientist;skills;social;Social Responsibility;Solid;statistics;Structure;Talents;Thinking;Time;Training;Training Activity;Training and Infrastructure;training opportunity;Training Programs;Translational Research;undergraduate student;underrepresented minority student;Underrepresented Populations;Universities;Update;Writing

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_DEPT: OTOLARYNGOLOGY

PHR: Falls (i) are common, (ii) directly injure or kill many Americans each year, and (iii) increase exponentially as we age. While many factors contribute to falls, we focus on vestibular degradation because new data show that age- related increases in vestibular thresholds mediate (“explain”) nearly half of age-related balance declines; related findings have led to estimates that up to 150,000 Americans might die each year due to sub-optimal vestibular function, including sub-clinical age-related vestibular declines. As crucial steps to reduce age-related falls, we propose extensive human testing designed to develop: (a) targeted vestibular screening tests by quantifying impacts of vestibular declines on age-related balance declines and falls and (b) a potential intervention designed to improve vestibular precision, which could also improve balance and reduce falls.

PI_NAMEs: MERFELD, DANIEL M (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Accidents;Accounting;Address;Adult;Age;age effect;age related;age related changes;age related decline;Aging;American;balance testing;Biological Assay;Cause of Death;Cessation of life;Clinical;Data;demographics;design;Educational Intervention;Equation;Equilibrium;Etiology;Eye;Failure;fall risk;falls;Feedback;healthy aging;Human;Impairment;improved;Individual;Injury;Intervention;Intuition;Life;Link;Measures;Mediating;Mediation;Medical Care Costs;Methods;Modeling;Modernization;National Health and Nutrition Examination Survey;Noise;novel;Odds Ratio;older adult;Participant;Perception;Perceptual learning;Peripheral;Population;Posture;Public Health;Publishing;Rehabilitation therapy;Reporting;Research;Romberg test procedure;screening;Sensory;Statistical Data Interpretation;Surveys;Testing;therapy design;Time;Training;Variant;Vestibular function;Vestibular Function Tests;vestibular system;Work;young adult

PROJECT_TITLE: Towards healthy aging: Quantifying vestibular contributors to age-related changes in balance and fall risk


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The clinical utility of atovaquone for treatment and prevention of malaria has validated the parasite’s cytochrome bc1 complex as a legitimate target for exploitation. In this application we focus on another bc1 inhibitor, ELQ-300, and seek to modify the structure of this molecule to more comprehensively block the enzyme target to enhance antimalarial potency, selectivity, and overall performance in vitro and in vivo in rodent models of disease infection.

PI_NAMEs: RISCOE, MICHAEL KEVIN (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: absorption;Address;Adherence;Animal Model;Anopheles Genus;Anti-malarials;Area;atovaquone;Biological Availability;Blood;Blood Circulation;Case Management;Chemoprevention;Chemoprotection;Chloroguanide;Clinical;Combination Drug Therapy;Complex;crystallinity;Culicidae;Cytochrome bc1 Complex;Cytochromes b;cytotoxicity;Data;design;Development;Digit structure;dimer;disease model;Drug Combinations;Drug Kinetics;Drug Targeting;Dust;Elements;Enzymes;Exhibits;Exposure to;Formulation;Genes;Genetic;Goals;Human;improved;In Vitro;in vitro activity;in vivo;in vivo evaluation;Infection;Infection prevention;inhibitor;Intestines;Journals;Knowledge;Lead;Life Cycle Stages;Liquid substance;Liver;Malaria;malaria infection;Malaria prevention;Mammalian Cell;Medicine;Metabolic;Midgut;Mitochondria;Modeling;monomer;Multi-Drug Resistance;Multienzyme Complexes;Mus;Mutation;nanomolar;novel;novel therapeutics;Oral;Parasites;Parasitology;Parents;Patient Compliance;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Phenotype;pill;Plasmodium;Plasmodium falciparum;Population;Positioning Attribute;pre-clinical;Predisposition;prevent outbreaks;Prodrugs;Property;prophylactic;Prophylactic treatment;protein structure;Publishing;Qi;Quinolones;Regimen;Resistance;Resistance development;resistance frequency;resistant Plasmodium falciparum;resistant strain;Risk;Rodent Model;scaffold;Seasons;Series;Side;Site;small molecule libraries;Solubility;Structure;Testing;toxicant;transmission blocking;transmission process;United States National Institutes of Health;Update;vector mosquito;water solubility;Work

PROJECT_TITLE: Novel Therapeutics to Target Parasite Cytochrome bc1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-F(83)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunization;Immunotherapy;Kidney Disease;Organ Transplantation;Orphan Drug;Rare Diseases;Transplantation

ORG_DEPT: SURGERY

PHR: Narrative Anti-HLA antibodies present a formidable barrier to achieving a successful kidney transplant in patient with end-stage renal failure. Many approaches have failed to reduce the level of anti-HLA antibodies. This proposal leverages a novel form of engineered T cell therapy to eradicate the cells responsible for producing these antibodies in patients on the kidney waiting list.

PI_NAMEs: BHOJ, VIJAY ;GARFALL, ALFRED L.;JUNE, CARL H.;MARKMANN, JAMES FRANCIS;MILONE, MICHAEL C.;NAJI, ALI  (contact)

PROGRAM_OFFICER_NAME: HAYES, DEBORAH

PROJECT_TERMS: Allografting;Antibodies;Antibody Repertoire;Antibody Response;Antigens;arm;Autologous;B cell therapy;B-Lymphocytes;Biology;cancer cell;CAR T cell therapy;CD19 gene;Cell Lineage;Cell Maturation;Cell Therapy;Cells;Cellular Immunity;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;clinically significant;cohort;Cohort Studies;Communicable Diseases;cost effective;Death Rate;desensitization;design;Disease remission;Disseminated Malignant Neoplasm;Dose;Dose Limiting;Drug Kinetics;efficacy evaluation;End stage renal failure;engineered T cells;Europe;Event;experience;Humoral Immunities;Immune;immune function;Immunity;immunodeficiency;Immunotherapy;improved;in vivo;Infusion procedures;innovation;Intravenous Immunoglobulins;Isoantibodies;Kidney;Kidney Transplantation;Laboratories;Leukapheresis;leukemia/lymphoma;longitudinal analysis;Malignant - descriptor;Malignant Neoplasms;manufacture;Measures;Medical;Memory B-Lymphocyte;Methods;Molecular;Molecular Analysis;mortality risk;Multiple Myeloma;novel;organ allocation;Outcome;Patients;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phenotype;Physiological;pilot trial;Plasma Cells;Plasma Exchange;Proteasome Inhibitor;Quality of life;Refractory;Regimen;Research Personnel;risk mitigation;Safety;safety and feasibility;T cell therapy;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Toxic effect;Transplantation;treatment choice;vaccine evaluation;vaccine response;Waiting Lists

PROJECT_TITLE: Autologous chimeric antigen receptor engineered T cell immunotherapy for desensitization in patients awaiting kidney transplantation


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Conditions Affecting the Embryonic and Fetal Periods;Endocannabinoid System Research;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Fetal alcohol spectrum disorders (FASD) caused by prenatal alcohol exposure have high prevalence (2-5%) in the US and the world. The proposal will investigate if prenatal ethanol exposure-induced persistent microglia activation contributes to impaired endocannabinoid signaling, which in turn leads to various synaptic dysfunctions and behavioral deficits. We will also investigate if reducing microglia activation can lead to normalization of PE-induced synaptic dysfunctions and behavioral deficits.

PI_NAMEs: SHEN, ROH-YU  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: addiction;Adult;Animals;Area;Attention;Behavior;Behavioral;Biological Models;Brain;Chronic;Cognitive;Cognitive deficits;Data;Development;dopaminergic neuron;Dose;effective intervention;endocannabinoid signaling;Endocannabinoids;Excitatory Synapse;Executive Dysfunction;experimental study;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Functional disorder;glial activation;Goals;High Prevalence;Homeostasis;Impairment;Inhibitory Synapse;interdisciplinary approach;Intervention;Knowledge;Lead;Learning Disabilities;Literature;Maintenance;male;Mediating;Methods;Microglia;Minocycline;Mood Disorders;Morphology;Neurodevelopmental Disorder;neuroinflammation;Neurons;neurotransmission;neurotransmitter release;perinatal alcohol exposure;Physiological;Play;Population;Prevalence;Rattus;receptor;Regulation;Reporting;Research;Risk;Role;sex;Study models;Synapses;synaptic function;Testing;Translating;Ventral Tegmental Area

PROJECT_TITLE: Role of Microglia in Prenatal ethanol exposure-induced Impairment of Endocannabinoid Signaling


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Disability Research;Machine Learning and Artificial Intelligence;Multiple Sclerosis;Neurodegenerative;Neurosciences

PHR: Project Narrative In this study, multiple institutions performing research using 7-tesla (7T) MRI research on patients with multiple sclerosis (MS) will combine data for a large scale, pooled analysis project. The investigators will refine methods for visualizing cortical and deep gray matter lesions, chronically inflamed white matter lesions, and meningeal inflammation on 7T MRI in MS and will evaluate their clinical relevance on a large scale and develop machine learning algorithms for future identification. It is expected that validating findings on 7T and their clinical relevance along with providing automated tools for analysis will lead to the use of 7T MRI as a more widespread clinical tool, resulting in earlier diagnoses, better prognostication, and more effective treatment monitoring in MS.

PI_NAMEs: HARRISON, DANIEL M (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: accurate diagnosis;Algorithmic Analysis;American;Autopsy;Baltimore;Biological Markers;Caring;Chronic;Clinical;clinical care;Clinical Data;Clinical Trials;clinically relevant;cognitive disability;comparative;Consumption;Data;Data Pooling;deep learning algorithm;Demyelinations;Development;Devices;Diagnosis;diagnostic tool;disability;Disability outcome;Early Diagnosis;effective therapy;Evaluation;follow-up;Functional disorder;Future;gray matter;high throughput analysis;Histopathology;Hospitals;Image;Image Analysis;Imaging technology;Impaired cognition;improved;in vivo;Individual;Inflammation;Inflammatory;insight;Institution;interest;Intervention;large datasets;Lead;Leptomeninges;Lesion;Link;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Manuals;Maps;Maryland;Masks;Measurement;Measures;Meningeal;Meninges;Methodology;Methods;Monitor;MRI Scans;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;National Institute of Neurological Disorders and Stroke;Nature;Neurologic;Pathology;Patient Care;Pennsylvania;Pharmacologic Substance;Phase;physically handicapped;Predisposition;Prognosis;prognostic tool;prognostication;Protocols documentation;Research;Research Design;Research Personnel;Research Project Grants;Sample Size;Scanning;screening;Site;Standardization;Structure;Techniques;Thalamic structure;Time;tool;Training;treatment effect;Universities;Validation;Visit;Visualization;white matter;Woman

PROJECT_TITLE: Pooled analysis of multiple sclerosis findings on multi-site 7 Tesla MRI

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Alzheimer’s disease is a devastating and untreatable disorder that afflicts more than 50 million Americans directly and countless additional family members and caregivers. Progress toward developing treatments for Alzheimer’s disease are hampered by deficiencies in current animal models, particularly a lack of animal models (1) showing pathological hallmarks and clinical features similar to those seen in patients with Alzheimer’s disease, and (2) having similar genetic and environmental heterogeneity to people. The companion dog uniquely captures both of these features, and this proposal synergistically leverages the infrastructure and resources of the Dog Aging Project to establish the companion dog as a premier animal model for Alzheimer’s disease.

PI_NAMEs: KEENE, CHRISTOPHER DIRK (contact);MCGRATH, STEPHANIE

PROGRAM_OFFICER_NAME: MORO, MANUEL H

PROJECT_TERMS: Age;age acceleration;age related;age related cognitive change;Aging;aging process;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer’s disease biomarker;American;Amyloid beta-42;Amyloid beta-Protein;Animal Model;Animals;Architecture;Autopsy;biobank;Biological Aging;Biological Preservation;Biological Specimen Banks;Blood;Body Size;Brain;Brain Pathology;Canis familiaris;Catalogs;Clinical;Clinical Chemistry;cloud based;Cognition;Cognitive;cognitive function;cognitive testing;cohort;college;companion animal;Companions;Comparative Study;Computerized Medical Record;Data;data repository;Data Set;data warehouse;Dedications;Dementia;Deposition;design;Diagnosis;Disease;Disease Marker;DNA;end of life;Enrollment;Environment;epigenome;expectation;Family Caregiver;Family member;fecal microbiome;Foundations;Future;Genetic;genome sequencing;Goals;Health;Health Status;healthspan;Heterogeneity;Human;hyperphosphorylated tau;Immunohistochemistry;Impaired cognition;Individual;Infrastructure;interest;Intervention;Life Experience;Link;longitudinal analysis;Longitudinal Studies;Mass Spectrum Analysis;Measures;metabolome;Molecular;molecular phenotype;neuropathology;Pathologic;Persons;Population Control;Privatization;Proteomics;Questionnaires;rate of aging;recruit;repository;Research;research clinical testing;Research Personnel;research study;Resolution;Resources;Sampling;Secure;Serum;Serum Markers;sex;Societies;Surveys;tau Proteins;Testing;Text;Time;Tissues;Universities;Veterinarians;Veterinary Medicine;whole genome

PROJECT_TITLE: Developing the Privately Owned Companion Dog as a Model for Alzheimers Disease


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Animal models have provided great insight into human disease including autoimmunity, however most animal model lack the genetic diversity of human populations. We propose that the Collaborative Cross (CC) mouse strains will improve our ability to study the genetics of autoimmunity. We believe that use of the CC strains will allow us to determine those genes that regulate the molecular and cellular pathways that lead to autoimmune disease.

PI_NAMEs: POLLARD, KENNETH MICHAEL (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Alleles;Animal Experiments;Animal Model;Antinuclear Antibodies;Asian;Autoantibodies;Autoimmune;Autoimmune biomarker;Autoimmune Diseases;Autoimmunity;Biological Markers;Biological Response Modifiers;Characteristics;chemokine;Chromosome Mapping;Chromosomes;Clinical;clinically relevant;Complex;Computer software;Coupled;cytokine;Data;Development;Disease;disease diagnosis;disease phenotype;Environmental Exposure;European;Event;Exhibits;Genes;Genetic;genetic association;Genetic Heterogeneity;Genetic study;genetic variant;Genetic Variation;Genome;genome-wide;genomic locus;Genotype;Goals;Health;Heterozygote;Human;human disease;Immunity;Immunologics;improved;Inbred Mouse;Inbred Strain;Inbred Strains Mice;Inbreeding;Individual;Inflammation;Inflammatory;inflammatory marker;Influentials;insight;Investigation;Laboratories;Laboratory mice;Link;lupus-like;Maps;Modeling;Molecular;mouse genome;Mouse Strains;Mus;Nuclear Antigens;Parents;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;phenotypic data;Population;Predisposition;Probability;Protocols documentation;Quantitative Trait Loci;Randomized;Recombinant Inbred Strain;Recombinants;Reproducibility;Research;Residual state;Resource Informatics;Resources;response;segregation;Severities;SNP array;systemic autoimmune disease;systemic autoimmunity;Systemic disease;Testing;therapeutic target;tool;trait;Variant

PROJECT_TITLE: Collaborative Cross Strains as Models of Systemic Autoimmunity

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Pediatric;Precision Medicine;Prevention;Rare Diseases;Sickle Cell Disease;Stroke

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Understanding patient and donor-related factors that influence the survival of red blood cell transfusions in children with sickle cell disease will provide information on mechanisms for improvement of hematologic and clinical responses to chronic transfusion therapy. This new information ultimately will help us to 1) identify reasons that patients may have poor responses to therapy and 2) modify donor aspects of transfusion therapy to improve treatment responses and decrease disease-related morbidity.

PI_NAMEs: YEE, MARIANNE ELAINE MCPHERSON (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: acute stroke;Adherence;Adolescent;Adult;Adverse event;Aliquot;Alloimmunization;Appearance;Benchmarking;Biotin;Biotinylation;Blood specimen;Blood Transfusion;career;Cell Aging;Cell Surface Proteins;Cell Survival;Cell Therapy;Cerebral Ischemia;Characteristics;Child;Childhood;Chronic;Circulation;Clinical;clinical efficacy;Clinical Research;Clinical Trials;cohort;Disease;Donor Selection;Early identification;effective therapy;Enrollment;Erythrocyte Transfusion;Erythrocytes;Erythropoiesis;experience;Failure;Future;Glucosephosphate Dehydrogenase;Glucosephosphate Dehydrogenase Deficiency;Goals;Hematology;Hemoglobin;Hemoglobin A;Hemoglobin concentration result;Hemoglobin SS;Hemolysis;Hour;Immune;Immune system;Immunologics;improved;improved outcome;in vivo;Individual;individual patient;interpatient variability;Intervention;Kinetics;Knowledge;Label;Learning;longitudinal analysis;Master of Science;Measures;Mediating;Membrane;Mentorship;Metabolic;metabolomics;Modeling;Morbidity - disease rate;Outcome;patient oriented research;Patient Selection;Patient-Focused Outcomes;Patients;Pattern;Pediatric Hematologist;personalized approach;Pilot Projects;Population;precision medicine;Production;Prophylactic treatment;prospective;Prospective Studies;Recording of previous events;Recovery;Regimen;Research;Research Personnel;response;Reticulocytes;Reticuloendothelial System;Risk Factors;Risk Reduction;Role;Sampling;senescence;Sickle Cell;Sickle Cell Anemia;sickle erythropoiesis;Specific qualifier value;Spleen;Splenomegaly;Stroke;stroke event;Stroke prevention;stroke risk;Surface;Time;Toxic effect;Transfusion;transfusion medicine;treatment response;Variant

PROJECT_TITLE: Kinetics of Red Blood Cell Clearance in Chronically Transfused Children with Sickle Cell Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]