ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Narrative Acquired resistance to therapy contributes to poor survival outcomes in cancer patients. The primary objective of this U54 application is to establish a successful and self-sustaining ARTNet Center for Pancreatic Cancer (ACPC) to explore novel mechanisms and combination therapies to target acquired resistance in pancreatic cancer. We will collaborate and work closely with other ARTNet centers, coordinating center, and the National Cancer Institute to provide novel mechanistic insights and translational opportunities to target therapy resistance with the long-term goal of improving overall patient survival.

PI_NAMEs: SINGH, PANKAJ KUMAR (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Advisory Committees;Biological Assay;cancer cell;Cancer Center;Cancer Patient;cancer therapy;Caring;Cells;chemotherapy;Circulation;Clinic;Clinical;Clinical Trials;Collaborations;Combined Modality Therapy;Companions;CRISPR screen;Data;Data Coordinating Center;Dedications;design;Development;Disease;Educational workshop;effective therapy;environmental stressor;Epigenetic Process;exosome;Exposure to;Fostering;Goals;Growth;Immune;improved;innovation;insight;Institution;Intercellular Fluid;Investigation;Knowledge acquisition;Leadership;lectures;Libraries;lipidomics;Malignant neoplasm of pancreas;Mediating;Mediator;meetings;member;Metabolic;metabolic phenotype;metabolomics;Methods;Mission;Modification;National Cancer Institute;neoplastic cell;novel;novel therapeutics;Outcome;Paclitaxel;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;patient prognosis;Patients;preclinical efficacy;prevent;Primary Neoplasm;Prognosis;programs;Proteins;Recording of previous events;Research;Resistance;resistance mechanism;Resource Sharing;Resources;response;Role;Sampling;Science;Scientist;Signal Transduction;single-cell RNA sequencing;Site;skills;sound;stable isotope;standard of care;Stromal Cells;Stromal Neoplasm;survival outcome;symposium;synergism;System;targeted treatment;Technology;Therapeutic;therapy resistant;tissue resource;tool;translational potential;translational study;Translations;treatment response;tumor metabolism;Validation;web site;Work

PROJECT_TITLE: Pancreatic Cancer ARTNet Center


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases;Transplantation

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE This proposal focuses on obstacles that need to be overcome to eradicate lymphomas linked to Epstein-Barr virus (EBV) using T cells specific for EBV (EBVSTs). These studies, if successful, will provide EBVSTs with an intrinsic ability to proliferate on antigen encounter and resistance to inhibition in the tumor environment using a constitutive cytokine receptor. They will evaluate an in vivo boost to reinvigorate the anti-lymphoma functions of infused EBVSTs using an EBV latency reversal agent, and will investigate an off-the shelf EBVST therapy for lymphoma that resists graft rejection and lacks graft versus host activity and would be immediately available to patients.

PI_NAMEs: ROONEY, CLIONA M. (contact)

PROJECT_TERMS: Aftercare;Allogenic;anergy;Antigen Targeting;Antigens;Apoptotic;arm;Autologous;B-Cell Neoplasm;B-Lymphocytes;Bar Codes;BCL2 gene;Biological Assay;Blood;cancer therapy;Caspase;cell killing;Cell Therapy;Cells;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical efficacy;Clinical Research;Clinical Trials;Coculture Techniques;constitutive expression;Cytokine Receptors;cytokine release syndrome;Cytokine Signaling;cytotoxic;Data;Donor Selection;Dose;EBV specific T-cells;Effector Cell;effector T cell;Engraftment;Environment;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Lymphoma;Frequencies;Functional disorder;Funding;Gene Expression;Goals;Graft Rejection;graft vs host disease;HDAC4 gene;Histone Deacetylase Inhibitor;Human;Human Herpesvirus 4;humanized mouse;IL7 Signaling Pathway;Immune response;improved;In complete remission;In Vitro;in vivo;inflammatory milieu;Infusion procedures;Interleukin 7 Receptor;Link;Lymphoma;Lytic Phase;Malignant - descriptor;manufacture;Measures;Modeling;mouse model;Mus;neoplastic cell;Neuroblastoma;novel strategies;Patients;Peripheral Blood Mononuclear Cell;Phenotype;pre-clinical;Pre-Clinical Model;preclinical study;Predisposition;prevent;programs;Proliferating;receptor expression;relapse patients;Resistance;response;Saliva;Signal Transduction;Sorting;Specificity;Stat5 protein;Stem cell transplant;T cell anergy;T cell therapy;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Time;TNFRSF8 gene;Toxic effect;transforming virus;Transgenes;Treatment Failure;tumor;tumor microenvironment;tumor-immune system interactions;Viral Antigens;Viral load measurement;Virus;Xenograft Model

PROJECT_TITLE: Project 3: Increasing the potency and accessibility of EBVSTs for the treatment of Lymphoma


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: NARRATIVE Adenomas are early lesions of colorectal cancer, but only a subset of adenomas progress and become cancer. In light of the well characterized clinical natural history of adenomas, we plan to study them as early lesions and to determine the mechanisms involved in the formation and progression of early precancerous lesions. We hypothesize that adenoma progression requires a suite of hallmark behaviors and that these behaviors are induced by adenoma autonomous factors (e.g. cancer driver gene mutations) and adenoma nonautonomous factors from the “primed colon” or adenoma microenvironment. Our proposed studies will integrate basic and translational cancer research projects to iteratively examine the direct causal relationships and interactions of adenomas, the colon “primed” microenvironment, and host-systemic factors as “co-organizers” of adenoma initiation and/or progression.

PI_NAMEs: DEY, NEELENDU ;GRADY, WILLIAM MALLORY (contact);HALBERG, RICHARD BROTT

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Aberrant DNA Methylation;adenoma;Affect;Architecture;Atlases;Basic Cancer Research;Behavior;Biological Markers;Biology;Cancer Etiology;cancer genetics;Cancer Research Project;cancer type;Cells;Cessation of life;Clinic;Clinical;clinical application;cohort;Collaborations;Colon;colon cancer patients;Colonic Adenoma;Colorectal Adenoma;Colorectal Cancer;colorectal cancer prevention;colorectal cancer progression;Data Set;deep sequencing;DNA Sequence Alteration;dysbiosis;Epigenetic Process;Epithelial Cells;experience;Fibroblasts;Gene Mutation;Goals;gut microbiome;Human;human disease;Immune;Individual;Indolent;innovation;Lesion;Light;Malignant Neoplasms;methylation pattern;methylome;microbiome;Mission;Molecular;mouse model;Multiomic Data;mutant;Mutation;Natural History;novel;Pathogenesis;Patients;Persons;Positioning Attribute;premalignant;Recording of previous events;Research Personnel;risk prediction;Science;senescence;Sessile Lesion;Technology;Testing;Tissues;translational cancer research;Translational Research;Translations;Tumor Promotion

PROJECT_TITLE: Understanding adenoma progression: Interplay among tissue microenvironment, clonal architecture, and gut microbiome


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Lymphatic Research;Lymphoma;Patient Safety;Rare Diseases

PHR: NARRATIVE The Clinical Research and Biostatistics Core supports the SPORE clinical research studies to ensure they are conducted safely, accurately and in accordance with applicable regulations. This Core (Core B) also provides all SPORE projects with statistical support for preclinical experiments and clinical trials.

PI_NAMEs: HESLOP, HELEN E (contact)

PROJECT_TERMS: Address;Adverse event;Annual Reports;Biological Products;Biometry;Biostatistics Core;care providers;Clinical;Clinical Data;clinical development;Clinical Management;Clinical Research;Clinical Research Protocols;Clinical Trials;Collaborations;college;Complex;Comprehensive Cancer Center;Conduct Clinical Trials;Consent Forms;Consultations;Data;Data Analyses;Data Collection;data management;Data Reporting;Databases;Dedications;design;Enrollment;Ensure;experience;experimental study;Futility;Good Clinical Practice;Human Resources;Individual;Infrastructure;Institution;Institutional Review Boards;Intranet;Lymphoma;Medicine;meetings;Monitor;Notification;Nursing Research;operation;Outcome;Patient Care;Patient Recruitments;Patients;Physicians;pre-clinical;preclinical study;Preparation;Principal Investigator;Procedures;programs;Protocol Compliance;protocol development;Protocols documentation;quality assurance;Quality Control;Randomized;Regulation;Regulatory Affairs;Reporting;Research;Research Design;Research Infrastructure;Research Personnel;research study;Research Support;Resource Sharing;Resources;Review Committee;Safety;Science;searchable database;Services;Statistical Methods;Statistical Study;System;Toxic effect;Training;Update;web site;Work

PROJECT_TITLE: Core B: Clinical Research


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PI_NAMEs: SANCHEZ, YOLANDA  (contact)

PROJECT_TERMS: Administrative Supplement;American Cancer Society;anti-cancer research;Applications Grants;Area;Autophagocytosis;Award;Basic Science;behavior measurement;Behavior Therapy;Behavioral Research;Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer genome;cancer health disparity;cancer prevention;care delivery;career;Catchment Area;Clinical;clinical center;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Colon Carcinoma;Colorectal;community academic partnership;community engaged approach;Comprehensive Cancer Center;Computational Science;cost;Data;design;Development;Direct Costs;DNA Repair;Doctor of Philosophy;early phase clinical trial;Eligibility Determination;environmental carcinogenesis;Epidemiology;Epigenetic Process;Ethnic Population;experience;Extramural Activities;Faculty;Faculty Recruitment;Funding;Funding Agency;genome sequencing;genome-wide analysis;Goals;graduate student;Grant;Growth and Development function;health disparity;Hepatitis C;Hispanic Populations;Human Papillomavirus;Image;Information Systems;Institution;Interdisciplinary Study;Investments;Journals;Laboratories;Leadership;Legal patent;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant Neoplasms;member;Mentors;Mexican;Mission;mortality;multi-ethnic;multidisciplinary;NCI Center for Cancer Research;New Mexico;oncolytic virotherapy;Outcome;Parents;patient engagement;patient population;Pattern;Peer Review;Phase;Philanthropic Fund;Pilot Projects;Play;population based;Population Sciences;Population Study;Postdoctoral Fellow;Pre-Clinical Model;Prevention Research;Process;programs;Progress Reports;Publications;Qualifying;recruit;Recurrence;Registries;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Resource Sharing;Resources;respiratory;RNA;Role;screening;Series;Special Population;Specialized Program of Research Excellence;Specimen;Targeted Research;Translational Research;tumor immunology;United States National Institutes of Health;Universities;Urogenital Cancer;working group

PROJECT_TITLE: Developmental Funds

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE The Cell and Vector Production Core (Core C) is essential for the clinical protocols proposed in each of the SPORE projects. The Core will be responsible for the preparation of therapeutic grade viral vectors and for manufacturing the various cellular therapy products that will be used in the proposed clinical trials. It will additionally assist in the translation of pre-clinical procedures into clinical scale manufacturing and testing. Core C will also provide the quality control and assurance services required to support the Good Manufacturing Practices infrastructure.

PI_NAMEs: LAPTEVA, NATALIA  (contact)

PROJECT_TERMS: Accreditation;Address;Adverse reactions;American;Antigen-Presenting Cells;Area;Australia;cell bank;cell preparation;Cell Therapy;Cells;Chemistry;Clinical;Clinical Laboratory Improvement Amendments;Clinical Protocols;Clinical Research;Clinical Trials;college;Contracts;Dedications;Development;Documentation;Effector Cell;Environmental Monitoring;Equipment;Europe;experience;Far East;Flow Cytometry;Foundations;Gene Modified;gene therapy;Generations;Genes;Genetic;Good Manufacturing Process;Immune;Individual;Infrastructure;International;Investigational Drugs;Investigational New Drug Application;Knowledge;Laboratories;Lymphoma;manufacture;Medicine;Modification;National Heart, Lung, and Blood Institute;Outcome;Pathologist;Phase;Plants;Population;pre-clinical;Preparation;Procedures;Process;Production;programs;Qualifying;quality assurance;Quality Control;Quality Indicator;Reagent;Records;Regulation;Research;Research Personnel;Resource Sharing;Services;Somatic Cell;Source;System;Testing;Therapeutic;Training;translational study;Translations;United States Food and Drug Administration;Validation;vector;Viral Vector

PROJECT_TITLE: Core C: GMP Cell and Vector Production


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

PHR: NARRATIVE The goal of the Biospecimen and Pathology Core is to provide high quality tissue and blood samples from lymphoma patients to investigators undertaking translational research studies in lymphoma. The core pathologists also provide support to the clinical trials in this SPORE by reviewing tissue and performing staining and other molecular tests for target antigens.

PI_NAMEs: SHEEHAN, ANDREA MARCOGLIESE (contact)

PROJECT_TERMS: Antigen Targeting;biobank;Bioinformatics;Biological Assay;biomedical informatics;Biopsy;Blood Cells;Blood specimen;Breast;cancer genetics;career;Catchment Area;Cells;Chromosomes;Chronic Lymphocytic Leukemia;Classification;CLIA certified;Clinical;Clinical Research;Clinical Trials;college;Comprehensive Cancer Center;Computer software;Cytogenetics;Databases;design;Detection of Minimal Residual Disease;Development;Diagnostic tests;Drug or chemical Tissue Distribution;Ensure;exome sequencing;experience;experimental study;Flow Cytometry;follow-up;Freezing;Fresh Tissue;Funding;Future;Gene Chips;General Hospitals;Genes;Genetic;genetic analysis;genome sequencing;Goals;Hematopathology;Histology;Hodgkin Disease;Hospitals;Immunohistochemistry;In Situ Hybridization;In Vitro;in vivo;in vivo Model;Institution;Laboratories;laser capture microdissection;leukemia/lymphoma;lymph nodes;Lymphoma;Lymphoma cell;Medical center;Medicine;Methodist Church;Microarray Analysis;Molecular;neoplastic cell;Non-Hodgkin's Lymphoma;novel therapeutic intervention;Online Systems;Paraffin;Paraffin Embedding;participant enrollment;Pathologist;Pathology;patient derived xenograft model;Patients;Pediatric Hospitals;Peripheral;Plasma;Population;preclinical study;repository;research and development;research clinical testing;Research Personnel;Research Project Grants;research study;Research Subjects;Resource Allocation;Resources;Sampling;Secure;Serum;Services;Site;Specimen;Stains;Support Groups;System;T-Lymphocyte;Testing;Texas;Tissue Banks;Tissue Microarray;tissue preparation;Tissue Sample;Tissues;transcriptome sequencing;Translational Research;Translations;tumor;Validation;viral RNA;virtual

PROJECT_TITLE: Core D: Biospecimen and Pathology Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: SUSSMAN, ANDREW LOUIS (contact)

PROJECT_TERMS: Address;Advocate;American Indian community;American Indians;anti-cancer research;Appointment;Area;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer health disparity;Cancer health equity;Cancer Intervention;cancer risk;care delivery;Catchment Area;Characteristics;Clinical Cancer Center;Clinical Trials;Clinical Trials Network;Communication;Communities;community advisory board;community engagement;Community Health Systems;Community Outreach;community partnership;community setting;Comprehensive Cancer Center;cultural competence;Data Sources;data warehouse;Development;Doctor of Philosophy;Education;environment related cancer;Environmental Exposure;evidence base;Evolution;Financial Hardship;financial toxicity;food insecurity;Funding;Genomic medicine;Grant;Guidelines;Health;health care availability;Healthcare;High Prevalence;Hispanic;hispanic community;HPV screening;Human Papilloma Virus Vaccination;Human Papillomavirus;Incidence;Informatics;innovation;Intervention Trial;Latinx population;Leadership;Linguistics;Link;Malignant Neoplasms;member;Mexican;Minority;Mission;Modeling;Molecular;Monitor;mortality;multi-ethnic;NCI Center for Cancer Research;New Mexico;Not Hispanic or Latino;outcome disparities;patient engagement;Patients;Pattern;Policies;population based;Poverty;precision medicine;Precision Medicine Initiative;programs;Protocols documentation;public education;Recommendation;Recording of previous events;Registries;Research;Research Priority;Resources;Review Committee;Risk Behaviors;Role;Rural Community;Rural Population;screening;Screening for cancer;SEER Program;Sexual and Gender Minorities;Site;socioeconomics;Specialist;Substance Use Disorder;survivorship;System;Training;Training Activity;Training and Education;Translational Research;tribal community;tribal Nation;Tribes;tumor registry;tv watching;Underrepresented Minority;underserved community;Underserved Population;Universities

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

PHR: NARRATIVE Our successful Lymphoma SPORE Developmental Research Program (DRP) will continue to support pilot projects of novel translational ideas in lymphoma research with the long-term goal of incorporating these projects into the SPORE or seeking independent funding for them in the future. The eight DRP projects (led by 5 women and 2 minority PIs) supported in our last funding cycle have already amassed $8.65 million dollars in external peer-reviewed funding. With the addition of a new co-leader in Dr. George Carrum, we aim to continue this successful track record while increasing diversity among our DRP awardees.

PI_NAMEs: BRENNER, MALCOLM K. (contact)

PROJECT_TERMS: Advisory Committees;Award;bench to bedside;Budgets;Cancer Center;Chronic Lymphocytic Leukemia;Clinical;Clinical Research;Collaborations;college;Data;Development;Diagnosis;Eligibility Determination;Ensure;Evaluation;feasibility research;Feedback;Female;flexibility;Funding;Future;Goals;Home;Hospitals;improved;innovation;Institution;Investments;Laboratory Research;Longterm Follow-up;Lymphoma;Malignant Neoplasms;Medical center;Medicine;meetings;Methodist Church;Minority;minority investigator;Monitor;Nature;Non-Malignant;novel;novel strategies;Peer Review;Performance;Pilot Projects;Program Research Project Grants;programs;Publications;Recommendation;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Rice;Scientist;Secure;Selection Criteria;Source;success;synergism;Talents;technology/technique;Testing;Texas;tool;Translating;translational potential;Translational Research;treatment strategy;Underrepresented Minority;Universities;Woman

PROJECT_TITLE: Developmental Research Program 1


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE – Overall  The Program Project's goal is to improve HPV vaccine communication and coverage in healthcare systems, a critically important opportunity for cancer prevention. We will create a package of intervention modules to accelerate improvements in HPV vaccine communication and uptake in healthcare systems.

PI_NAMEs: BREWER, NOEL TODD (contact)

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: Acceleration;Address;Administrative Coordination;Adolescent;Adoption;Area;Behavioral;budget impact;Cancer Control;cancer prevention;Clinic;Clinical;Communication;Communities;contextual factors;cost;cost effectiveness;Data;Data Collection;data management;Decision Aid;Educational Intervention;effective intervention;Effectiveness;Evolution;Face;financial incentive;Goals;Healthcare Systems;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;improved;insight;Intervention;intervention program;Malignant Neoplasms;Medical;models and simulation;National Cancer Institute;novel;Nurse's Role;Online Systems;Parents;Perception;population health;prevent;Prevention;Primary Care;primary care team;Program Research Project Grants;programs;Provider;randomized, clinical trials;Recommendation;Research;Research Activity;Research Project Grants;Resources;Rural;rural area;support tools;Surveys;synergism;System;Testing;Training;Training Activity;Training Programs;uptake;vaccine acceptance;Work

PROJECT_TITLE: Program Project – Improving Provider Announcement Communication Training (IMPACT)


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Hematology;Lymphatic Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: The Mayo Clinic Cancer Center seeks to renew its well-established career development program entitled, “The Paul Calabresi Program in Clinical/Translational Research at the Mayo Clinic,” requesting 5 positions to train the next generation of investigators who will learn to conduct patient-oriented, cutting edge, hypothesis-driven, practice-changing cancer research.

PI_NAMEs: JATOI, AMINAH  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Academia;Advisory Committees;anti-cancer research;Award;career;career development;Clinic;Clinical;Clinical Trials;cohort;Comprehensive Cancer Center;Doctor of Medicine;Doctor of Philosophy;experience;Funding;Future;Hematology;hepatobiliary cancer;improved;Infrastructure;innovation;Institution;Instruction;Leadership;Lymphoma;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mayo Clinic Cancer Center;Mentors;Methods;multidisciplinary;National Cancer Institute;National Clinical Trials Network;neuro-oncology;next generation;novel therapeutics;Oncology;patient oriented research;Positioning Attribute;Principal Investigator;Program Development;programs;Publications;Records;Research;Research Personnel;Specialized Program of Research Excellence;System;Time;Training;Training Programs;translational cancer research;Translational Research;Woman;Work

PROJECT_TITLE: Paul Calabresi Program in Clinical/Translational Research at Mayo Clinic

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

PHR: PROJECT NARRATIVE The goal of this program is to provide training in translational research in lymphoma for a diverse group of young investigators or established investigators who wish to refocus their career on lymphoma. This Lymphoma SPORE’s Career Enhancement Program aims to increase the number of promising investigators working in this field in the future through tailored learning programs, expert mentorship, and individualized training in the translation of cell and gene therapies for lymphoma.

PROJECT_TERMS: African American;Area;Basic Science;bench to bedside;Biochemistry and Cellular Biology;Bioethics;Biometry;career;Cell Therapy;Cells;Cessation of life;Clinical;Clinical Investigator;Clinical Research;Collaborations;college;Complex;Dedications;design;Development;Doctor of Philosophy;editorial;Education;Ensure;Environment;Epidemiologist;Epidemiology;Equity;equity, diversity, and inclusion;Ethics;Evaluation;Faculty;Female;Fostering;Funding;Future;gene therapy;Genetic;Goals;Healthcare;Hispanic Americans;Hospitals;Immunology;improved;Incentives;Individual;Investments;Laboratories;Lead;Learning;lectures;Lymphoma;Medicine;member;Mentors;Mentorship;Methodist Church;Methods;Minority;Molecular and Cellular Biology;Monitor;Pathologic;Pathology;patient oriented research;Peer Review;Pharmacology;Physicians;Pilot Projects;Private Practice;Process;Production;Productivity;programs;Publishing;recruit;Research;Research Personnel;Research Project Grants;role model;Science;Scientist;Selection Criteria;skills;success;Therapeutic Studies;tool;Training;Training Programs;Translational Research;translational scientist;Translations;Underrepresented Minority;vector;Woman;Work

PROJECT_TITLE: Career Enhancement Program


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Digestive Diseases;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE This project is relevant to public health and the mission of NICHD because it will help to characterize the function of human milk beyond nutrition by identifying milk protein-derived bioactive peptides released within the gut of preterm infants with gut health-promoting functions. Understanding the roles and identities of these bioactive peptides will contribute significantly to understanding the benefits of human milk to infant health and how to maximize those benefits to promote the healthy development of preterm infants. This proposal specifically addresses two of the NICHD Pediatric Growth and Nutrition Branch's Research Priorities:1) Human Milk Composition and Function (particularly how human milk composition changes with digestion and interacts with the infant intestine), and 2) Nutrition for Preterm Infants (particularly understanding the role of bioactive components of human milk (e.g., peptides) in feeding preterm infants).

PI_NAMEs: SCOTTOLINE, BRIAN  (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Address;Amino Acids;Anti-Bacterial Agents;antimicrobial;Biological;Biological Assay;Biological Models;Biology;Brain Injuries;Bronchopulmonary Dysplasia;candidate identification;Cattle;Cell Physiology;Cell Proliferation;Cellular biology;Childhood;cytokine;Data;Databases;Development;Digestion;Enteral Nutrition;Epithelial Cells;Exhibits;feeding;Fortification;Gastrointestinal tract structure;Gene Expression;Goals;Growth;Growth and Development function;gut health;gut microbiome;Health Promotion;Human;Human Biology;Human Milk;Immune system;immunoregulation;improved;In Vitro;in vitro activity;in vitro testing;in vivo;Infant;Infant Health;Inflammatory;innovation;Intestinal Content;intestinal epithelium;Intestines;late onset sepsis;Liquid substance;Macrophage;Mass Spectrum Analysis;Measures;Mediating;microbiome;Milk;Milk Proteins;Minimum Inhibitory Concentration measurement;Mission;Modeling;National Institute of Child Health and Human Development;Necrotizing Enterocolitis;neonatal care;neonatal human;Neonatal Intensive Care Units;Neonatology;novel;nutrition;pasteurization;Peptide Synthesis;Peptides;Physiology;Premature Infant;preterm newborn;Proliferating;protein expression;Proteins;Proteomics;Public Health;R peptide;Research;Research Priority;response;Retinopathy of Prematurity;Risk;Role;sample collection;Sampling;Source;statistics;Stimulus;Techniques;Testing;Time;Work

PROJECT_TITLE: Defining bioactivities of peptides released from human milk proteins in the preterm infant intestine

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Cancer;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Platinum resistance is probably the most important factor contributing to ovarian cancer recurrence and mortality. This application aims to understand the molecular mechanism responsible for platinum resistance of ovarian cancer. This application also aims to develop an effective strategy to overcome platinum resistance by blocking the function of SRMS, a key regulator of platinum resistance in ovarian cancer.

PI_NAMEs: HUANG, SHUANG  (contact);JIN, LINGTAO

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Apoptosis;Apoptotic;aptamer;C-terminal;cancer cell;Cancer cell line;Cancer Patient;cancer recurrence;Cell Line;Cells;Cessation of life;chemotherapy;Clinic;Cytotoxic agent;Data;data mining;Data Set;Death Rate;Defect;Development;drug repurposing;Early Diagnosis;efficacy evaluation;Event;Excision;Glean;Goals;improved;In Vitro;in vivo Model;Induction of Apoptosis;inhibitor;insight;Investigation;knock-down;Knock-in;Knowledge;Laboratories;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;MAPK8 gene;MCL1 gene;Mediating;Mediator;Minor;Molecular;mortality;N-terminal;Neurons;novel;Outcome;p53 Signaling Pathway;patient derived xenograft model;Patients;Phosphorylation;Phosphotransferases;Platinum;Play;prevent;Probability;Protein Kinase;Proteins;public database;Recurrence;Resistance;Role;screening;Serous;Signal Pathway;Signal Transduction;Site;SKOV3 cells;Small Interfering RNA;success;Surgical Management;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;TP53 gene;Tyrosine;Ubiquitination;Work

PROJECT_TITLE: Novel protein kinase signaling associated with platinum resistance in ovarian cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT 1 NARRATIVE Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant diseases whose applicability has been impeded by the development of its most serious complication, GI GVHD. Strategies that strengthen the target cells in the GI tract will allow for better harnessing of this effective therapeutic modality. Project 1 uses animal models to focus on the bioenergetics abnormalities and mitochondrial damage in intestinal stem cells caused by GVHD.

PI_NAMEs: REDDY, PAVAN  (contact)

PROJECT_TERMS: Allogenic;Animal Model;Bioenergetics;Biology;Bone Marrow Transplantation;Butyrates;Cells;Complex;Complication;Critical Pathways;curative treatments;Data;Defect;Development;Disease;Electron Transport;Epithelial Cells;gastrointestinal;Gastrointestinal tract structure;Glycolysis;Goals;Hematopoietic Stem Cell Transplantation;Immunosuppression;In Vitro;in vivo;insight;intestinal epithelium;Intestinal Graft Versus Host Disease;Intestines;LGR5 gene;Maintenance;Malignant - descriptor;Mediating;Metabolic;Metabolism;microbial;Mitochondria;Modality;Molecular;Morbidity - disease rate;mortality;novel;Paneth Cells;Play;preservation;prevent;Proliferating;Propionates;Publishing;Regulation;resilience;Role;Seminal;Severities;stem cell function;stem cells;Succinate Dehydrogenase;Testing;therapeutically effective;Tissues;Volatile Fatty Acids;Work

PROJECT_TITLE: Project 1: Mitochondrial Bioenergetics and Metabolism of ISCS in GVHD


NIH_SPENDING_CATS: Cancer;Clinical Research

PI_NAMEs: NESS, SCOTT A. (contact)

PROJECT_TERMS: animal imaging;Animal Model;anti-cancer research;Appointment;Award;behavior measurement;benefit sharing;Bioinformatics;Biometry;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;cellular imaging;Charge;Clinical;Clinical Trials;Collaborations;Complement;Consultations;Contract Services;Correlative Study;cost;cost effective;Cost Sharing;Development;Direct Costs;Doctor of Philosophy;Equipment;equipment acquisition;Equipment and Supplies;Extramural Activities;Faculty;Feedback;Fees;Flow Cytometry;fluorescence imaging;Funding;Genomics;Goals;Grant;Growth;human tissue;improved;innovation;Institution;instrumentation;Investments;Leadership;Link;Malignant Neoplasms;meetings;member;microscopic imaging;Microscopy;Modeling;NCI Center for Cancer Research;New Mexico;news;Newsletter;Peer Review;population based;Population Sciences;Process;programs;Publishing;recruit;Research;Research Personnel;Reservations;Resource Sharing;Resources;response;Role;Scientist;Services;Strategic Planning;Students;success;Suggestion;Supervision;Surveys;System;Technology;Tissue Banks;Tissues;translational cancer research;translational genomics;Translational Research;translational scientist;Translations;United States National Institutes of Health;Universities;Update;Wages;web page

PROJECT_TITLE: Shared Resource Management


NIH_SPENDING_CATS: Cancer;Hematology;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: PROJECT 2 NARRATIVE Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant diseases whose applicability has been impeded by the development of its most serious complication, GI GVHD. Strategies that strengthen the target cells in the GI tract will allow for better harnessing of this effective therapeutic modality. Project 2 uses animal models to investigate the role of enzyme RIP1 that causes death of intestinal stem cells and methods to inhibit RIP1 activation and thereby reduce GVHD.

PI_NAMEs: FERRARA, JAMES L. M. (contact)

PROJECT_TERMS: Acceleration;Allogeneic Bone Marrow Transplantation;Allogenic;Animal Model;Apoptosis;Apoptotic;Biological Markers;Biopsy;Bone Marrow Transplantation;Cause of Death;Cell Death;cell injury;Cell Line;Cells;Cessation of life;Collaborations;Complement;Complex;Complication;curative treatments;Data;Development;Disease;Enzymes;Experimental Models;Gastrointestinal tract structure;Genetic Complementation Test;graft vs host disease;graft vs leukemia effect;Hematopoietic Stem Cell Transplantation;high risk;Histopathology;Human;in vivo;Inflammatory;inhibitor;Intestines;Leukemic Cell;Malignant - descriptor;Mediating;Metabolic;Methods;Mitochondria;Modality;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Natural regeneration;novel strategies;Organoids;Outcome;Patients;pharmacologic;phase II trial;pre-clinical;prevent;Protein Kinase Interaction;Proteins;Receptor Activation;Receptor Inhibition;Receptor-Interacting Protein;Regenerating islet derived protein 3-Gamma;regenerative;restoration;RIPK1 gene;RIPK3 gene;Role;Scanning;Severities;stem cells;therapeutically effective;TNF gene

PROJECT_TITLE: Project 2: Inhibition of RIPK1 Mediated Cell Death to Prevent GVHD


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: PROJECT 3 NARRATIVE Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant diseases whose applicability has been impeded by the development of its most serious complication, GI GVHD. Strategies that strengthen the target cells in the GI tract will allow for better harnessing of this effective therapeutic modality. Project 3 will conduct two clinical trials of primary treatment based on the amount of GI damage at the time of treatment as determined by serum biomarkers.

PI_NAMEs: LEVINE, JOHN  (contact)

PROJECT_TERMS: Address;Algorithms;Allogenic;Biological Markers;Bone Marrow Transplantation;Categories;Cells;Clinical;Clinical Trials;cohort;comparison control;Complication;curative treatments;Data;Development;Disease;disease natural history;Dose;efficacy testing;Exhibits;Exposure to;Frequencies;gastrointestinal;Gastrointestinal tract structure;graft vs host disease;Hematopoietic Stem Cell Transplantation;high risk;improved;improved outcome;Infection;inhibitor;innovation;Intestines;Malignant - descriptor;Measures;Modality;Molecular;Monitor;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Outcome;outcome prediction;overtreatment;Patient Outcomes Assessments;patient subsets;Patients;Phase;Phase II Clinical Trials;phase II trial;Physical Function;Population;Pre-Clinical Model;predict clinical outcome;prevent;Probability;Quality of life;Reproducibility of Results;response;response biomarker;RIPK1 gene;Risk;Running;Safety;Serum;Severities;Site;stem cells;Steroids;Symptoms;Testing;therapeutically effective;Time;treatment response;treatment strategy

PROJECT_TITLE: Project 3: Risk Adapted Clinical Trials of GVHD Treatment


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: CORE 1 NARRATIVE Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant diseases whose applicability has been impeded by the development of its most serious complication, GI GVHD. Strategies that strengthen the target cells in the GI tract will allow for better harnessing of this effective therapeutic modality. Core 1 contains the administrative, biostatistical support and database operations support for all three projects.

PROJECT_TERMS: Accountability;Acute Graft Versus Host Disease;Allogenic;Biological Markers;Biometry;Bone Marrow Transplantation;Categories;Cells;Clinical;clinical database;Clinical Trials Design;Committee Members;Complication;cost effective;curative treatments;Data;Data Coordinating Center;data sharing;Databases;Development;Disease;Doctor of Philosophy;Experimental Designs;Experimental Models;Gastrointestinal tract structure;Generations;Hematopoietic Stem Cell Transplantation;Individual;innovation;Laboratories;Malignant - descriptor;Modality;Molecular;Monitor;operation;Patients;Process;programs;Reporting;Research;Sample Size;Services;Statistical Data Interpretation;statistical service;therapeutically effective

PROJECT_TITLE: Admin Core: Administration, Biostatistics and Data Coordinating Center


NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: MULLER, CAROLYN Y (contact)

PROJECT_TERMS: Address;Advisory Committees;Age;Age Years;aged;American Indians;anti-cancer research;Biological Markers;Black race;Budgets;cancer care;Cancer Center Support Grant;cancer clinical trial;cancer genome;cancer health disparity;Cancer Patient;care delivery;Catchment Area;Center for Translational Science Activities;Childhood;Clinical;Clinical Cancer Center;Clinical Data;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Trials;Clinical Trials Network;Communities;Community Clinical Oncology Program;community engagement;Community Health;Community Networks;Community Participation;Community Practice;Comprehensive Cancer Center;Contracts;Critiques;Data;data management;data warehouse;Development;Disease;Disparity;Doctor of Philosophy;early phase trial;Ensure;ethnic minority;Ethnic Population;Evaluation;Funding;Future;genome sequencing;Goals;Graduation Rates;Grant;Health Personnel;high school;Hispanic;human old age (65+);Improve Access;improved;Incidence;Industry;Informatics;Infrastructure;innovation;Institution;Intervention;Intervention Trial;investigator-initiated trial;Investments;Latinx;Malignant Neoplasms;Medicaid;Mentors;Mexican;Minority;Mission;Modeling;Modernization;Monitor;NCI Center for Cancer Research;neoplasm registry;New Mexico;Not Hispanic or Latino;Oncologist;operation;organizational structure;patient engagement;patient safety;Patients;Pattern;Performance;personalized intervention;Persons;Physician Executives;Physicians;Population;Poverty;precision medicine;Prevention;process improvement;programs;Protocols documentation;quality assurance;racial minority;racial population;Recommendation;recruit;Regulation;Research;Research Infrastructure;Research Personnel;Resource Sharing;response;Rural Population;Safety;Science;screening;severe COVID-19;Site;Structure;Therapeutic Trials;Training;Translating;Translational Research;Translations;trial design;tumor registry;Underserved Population;Uninsured;Universities;Update;waiver;Woman;working group

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: CORE 2 NARRATIVE Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant diseases whose applicability has been impeded by the development of its most serious complication, GI GVHD. Strategies that strengthen the target cells in the GI tract will allow for better harnessing of this effective therapeutic modality. Core 2 provides support for organoid models, biomarker analysis and computer programming, and is used by all three projects.

PROJECT_TERMS: Allogenic;Apoptotic;arm;Bar Codes;biobank;Biological Markers;Bone Marrow Transplantation;Cells;Clinical;clinical database;Clinical Trials;Complication;computer program;curative treatments;Data;Databases;Development;Disease;Eligibility Determination;Evaluation;flexibility;gastrointestinal;Gastrointestinal tract structure;Hematopoietic Stem Cell Transplantation;Hour;Human;In Vitro;Intestines;Link;Malignant - descriptor;Modality;Modeling;Molecular;Mus;Organoids;Pathway interactions;patient screening;Patients;Process;Quality Control;Reporting;Research;Sampling;Services;Site;stem cells;therapeutically effective;Tube;tv watching

PROJECT_TITLE: Core 2: Biorepository, Biomarker Analysis and GI Organoids


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PI_NAMEs: SINGH, PANKAJ KUMAR (contact)

PROJECT_TERMS: Advisory Committees;Advocate;anti-cancer research;Area;Basic Cancer Research;Basic Science;Bioinformatics;Biometry;Cancer Biology;Cancer Center;cancer therapy;Collaborations;Communication;Communities;Data;Data Coordinating Center;data integration;Dedications;Development;Education;Environment;Faculty;Fostering;Funding Agency;Future;Goals;graduate student;Grant;Human Resources;Immune;Information Dissemination;Infrastructure;innovation;Institution;interest;Intervention;Joints;Laboratories;Lead;Leadership;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical center;meetings;member;Metabolic;Metabolism;Monitor;mouse model;National Cancer Institute;Nebraska;next generation;novel;novel therapeutic intervention;Occupational activity of managing finances;operation;Organoids;Pilot Projects;Postdoctoral Fellow;prevent;programs;Progress Reports;prospective;Records;Research;Research Personnel;Research Project Grants;Resistance;resistance mechanism;Resources;Schedule;Science;Scientist;Signal Transduction;Stromal Neoplasm;Students;Talents;Technical Expertise;Testing;therapy resistant;Tissues;translational cancer research;translational pipeline;Translational Research;translational research program;Travel;tumor;tumor metabolism;Universities;web portal;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PI_NAMEs: GRANDGENETT, PAUL M (contact)

PROJECT_TERMS: Acute;Adrenal Glands;Archives;Ascites;Autopsy;Benign;biobank;Biological;Biopsy;Cancer Center;Cell Culture Techniques;Cell Line;Chronic;Clinical;Clinical Data;Clinical Trials;Collaborations;Collection;Core Facility;Database Management Systems;Dedications;Diagnostic;Diagnostic Procedure;Disease;disease model;Disease Resistance;DNA;Duodenum;Eligibility Determination;Ensure;Fibrosis;Fresh Tissue;Goals;Growth;Histologic;Human;Informed Consent;Intercellular Fluid;Large Intestine;Liquid substance;Liver;Lung;lymph nodes;Lymphocyte;Malignant - descriptor;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical center;Modeling;multidisciplinary;Muscle;Nebraska;Neoplasm Metastasis;neoplastic;Neuroendocrine Tumors;novel;Oncology;Operative Surgical Procedures;Organ;Organ Procurements;Organoids;Pancreas;Pancreatic carcinoma;Pancreatic Ductal Adenocarcinoma;Pancreatitis;Patient Care;Patient Monitoring;Patients;peripheral blood;Peripheral Blood Lymphocyte;Plasma;Procedures;programs;Quality Control;Recording of previous events;repository;Reproducibility;Research;Research Activity;Research Personnel;research study;Resistance;resistance mechanism;Resources;Respiratory Diaphragm;Risk;sample archive;Sampling;Scientist;Sequence Analysis;Serum;Small Intestines;Specimen;Spleen;System;therapy resistant;Tissue Banks;Tissues;Translational Research;Universities;Writing;Xenograft procedure

PROJECT_TITLE: Tissue Core-UNMC Rapid Autopsy Program


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

PROJECT_TERMS: Address;Biological Assay;cancer cell;Carbon;Cell Line;Cells;chemotherapy;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Community Networks;Complex;cost effective;Coupled;Data Analyses;Data Coordinating Center;Data Scientist;Dependence;design;Drug Kinetics;effective therapy;Ensure;exosome;experimental study;extracellular;follow-up;Gas Chromatography;genetic manipulation;Genomic Library;Genus Hippocampus;Goals;Human;human tissue;improved;Information Dissemination;Infrastructure;innovation;Intercellular Fluid;Investigation;Kinetics;Label;large scale data;Leadership;Libraries;lipidomics;Liquid Chromatography;Malignant neoplasm of pancreas;Mass Fragmentography;Mass Spectrum Analysis;Measures;Mediator;Medical center;member;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Mus;Nebraska;neoplastic cell;novel;novel therapeutics;online resource;Organoids;Oxygen Consumption;Pancreatic Ductal Adenocarcinoma;patient prognosis;Patients;Pharmaceutical Preparations;Pharmacodynamics;Physiological;programs;Publications;Publishing;Quality Control;Research Personnel;Resistance;Sampling;screening;Services;Signal Transduction;Specimen;stable isotope;Stable Isotope Labeling;Statistical Methods;Stromal Neoplasm;tandem mass spectrometry;Testing;therapy resistant;three dimensional cell culture;Tissues;Training;tumor;tumor metabolism;Tumor Tissue;Universities;whole genome;Work

PROJECT_TITLE: Cancer Metabolism Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Prevention

PI_NAMEs: MCGUIRE, ELIZABETH  (contact)

PROJECT_TERMS: Address;authority;Behavioral;Biometry;cancer care;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer health disparity;Catchment Area;Center for Translational Science Activities;Clinical;Clinical Cancer Center;Clinical Research;clinical trial protocol;Clinical Trials;Clinical Trials Network;Collaborations;Communities;Community Clinical Oncology Program;community engagement;Community Health;Community Health Systems;Community Outreach;Comprehensive Cancer Center;Data;data warehouse;design;Diagnosis;Disease;Eligibility Determination;Ensure;expectation;Feasibility Studies;Funding;Goals;Health system;Human;human subject;Incidence;Industry;Infrastructure;innovation;Institution;Institutional Review Boards;Intervention;investigator-initiated trial;Light;Malignant Neoplasms;member;Minority;minority patient;Modernization;molecular oncology;Monitor;mortality;National Clinical Trials Network;New Mexico;Oncology;Patients;Pattern;Peer Review;Performance;performance site;Persons;Pharmacologic Substance;Physicians;Population;Population Heterogeneity;Population Sciences;Prevention;Process;process improvement;programs;Protocols documentation;Recommendation;Research;research clinical testing;Research Design;Research Personnel;research study;Resources;response;Risk;Safety;Safety Management;safety study;Science;Scientific Evaluation;screening;SEER Program;Site;sound;Sushi Domain;System;Therapeutic;timeline;Translating;Translations;tumor;tumor registry;underserved minority;United States National Institutes of Health;Universities;Withdrawal;Work;working group

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

PROJECT_TERMS: Acidity;acquired immunity;Address;Adenosine;alpha ketoglutarate;Amino Acids;Anabolism;Arginine;Arginine deiminase;Blood Vessels;Cancer Etiology;Cell Line;Cells;Cessation of life;Charge;Chemoresistance;chemotherapy;Circulation;Clinical;Complement;CRISPR library;CRISPR screen;Data;deprivation;Development;Diagnosis;Diffusion;ecto-nucleotidase;Epigenetic Process;Event;Feeds;Future;Generations;Genes;genetic signature;Genetic Transcription;genome-wide;Glucose;Glycolysis Inhibition;Human;human tissue;Hypoxia;Immune;improved;insight;Intercellular Fluid;Invaded;knock-down;Malignant neoplasm of pancreas;Mediating;Metabolic;Metabolic Pathway;Metabolism;Myeloid-derived suppressor cells;neoplastic cell;novel;novel therapeutics;Oncogenic;Organoids;Oxidative Phosphorylation;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;Pathway interactions;patient derived xenograft model;patient prognosis;Patients;Phenotype;Phosphoglycerate dehydrogenase;Post-Translational Protein Processing;Prediction of Response to Therapy;predictive marker;prevent;Production;Prognosis;programs;protein protein interaction;Proteins;Proteomics;Purines;recruit;Regulation;Relapse;Resistance;Resistance development;response;Role;Serine;Side;Signal Transduction;Site;Specimen;Stromal Neoplasm;T-Cell Activation;Testing;Therapeutic;therapy resistant;tissue resource;treatment response;tumor;tumor microenvironment;tumorigenic;United States

PROJECT_TITLE: Metabolic regulation of FOLFIRINOX acquired resistance in pancreatic cancer


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Pancreatic Cancer;Rare Diseases

PI_NAMEs: HOLLINGSWORTH, MICHAEL A. (contact)

PROJECT_TERMS: Affect;Apoptosis;Biological;Biological Products;Breast;cancer stem cell;cancer type;Cells;chemotherapy;Cisplatin;Collaborations;Colorectal;Data;Distant;Drug resistance;Estrogen Receptors;Etoposide;exosome;extend lifespan;Fibroblasts;Future;gemcitabine;Gene Expression Profile;Gene Expression Profiling;Genetic Transcription;Genomics;glucose metabolism;glucose uptake;Head and neck structure;Immune;Immunofluorescence Immunologic;Immunotherapy;Induction of Apoptosis;Inhibition of Apoptosis;insight;Invaded;kidney cell;knock-down;Laboratories;lenalidomide;Location;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediator;Metabolic;Molecular;Molecular Target;Motility;Mucin 1 protein;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Oncogenic;Paclitaxel;Pancreas;pancreatic cancer cells;pancreatic cancer patients;Pathway interactions;Patients;Pharmaceutical Preparations;Play;Primary Neoplasm;Process;programs;Property;Radiation;refractory cancer;Resistance;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Site;Stomach;Tamoxifen;Techniques;therapy resistant;Tissues;transcription factor;transcriptomics;translational study;Trastuzumab;tumor;tumor growth;tumor microenvironment;Up-Regulation;virtual

PROJECT_TITLE: MUC1 in Therapy Resistance


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Natural Products;Pancreatic Cancer;Rare Diseases

PI_NAMEs: DONG, JIXIN  (contact)

PROJECT_TERMS: Affect;Affinity;Albumins;Animal Model;Animals;anti-tumor agent;Binding;Biochemical;cancer cell;Cancer Etiology;cancer therapy;cancer type;cell growth;Cells;Cellular biology;Cessation of life;Chemoresistance;chemotherapy;Chromosomal Instability;Clinic;Clinical;Clinical Trials;Combined Modality Therapy;cytotoxicity;Data;Drug resistance;drug sensitivity;efficacy outcomes;FDA approved;gemcitabine;Genes;Genetic;Genetic Epistasis;Genetic Transcription;Goals;Growth;HDAC4 gene;Histone Deacetylase;histone deacetylase 2;Histone Deacetylase Inhibitor;Immunocompetent;immunodeficiency;improved;In Vitro;in vivo;KPC model;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mediating;Metabolism;Methods;Microtubules;Mitotic;Molecular;mortality;nanoparticle;novel;Outcome;Paclitaxel;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathway interactions;patient derived xenograft model;patient response;Patients;Pharmaceutical Preparations;Phosphorylation;Phosphorylation Site;Phosphotransferases;pre-clinical;Prognostic Marker;programs;Proteins;Recurrence;Regulation;Resistance;response;Role;Serine;Signal Pathway;Signal Transduction;Survival Rate;Testing;Text;Therapeutic;therapeutic target;Transcription Coactivator;Translating;Treatment outcome;Tubulin;United States;upstream kinase;Vorinostat

PROJECT_TITLE: Targeting MARK2-HDAC signaling to overcome paclitaxel resistance in pancreatic cancer


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

PI_NAMEs: PALANISAMY, VISWANATHAN  (contact)

PROJECT_TERMS: Adopted;anti-cancer research;Applications Grants;base;Basic Cancer Research;Basic Science;Bioinformatics;Bioinformatics Shared Resource;Biological Assay;Biometry;Biostatistics Shared Resource;Budgets;Cancer Center;Cancer Center Support Grant;cancer genomics;Catchment Area;ChIP-seq;Clinical;Clinical Research;Cloud Computing;complex data;Computer software;computing resources;cost effective;cost estimate;Coupled;CRISPR/Cas technology;Data;Data Analyses;Data Set;Development;DNA sequencing;Doctor of Philosophy;Education;empowerment;Epigenetic Process;Equipment;experience;Experimental Designs;Faculty;Feedback;Fees;Formaldehyde;functional genomics;Funding;Gene Expression;Gene Expression Profile;gene panel;Genes;genetic variant;genome resource;Genomic approach;genomic platform;Genomics;Genomics Shared Resource;Germ-Line Mutation;Goals;Guidelines;human tissue;improved;Infrastructure;innovation;innovative technologies;instrument;Ions;Laboratories;large datasets;Lentivirus Vector;Libraries;Link;Malignant Neoplasms;Mediating;meetings;member;Methodology;Modeling;New Mexico;new technology;Newsletter;next generation sequencing;Outcome;Paraffin Embedding;Pathway interactions;Patients;Peer Review Grants;personalized medicine;Play;Precision therapeutics;programs;Protons;Publications;Quality Control;Reporting;Research;Research Personnel;Reservations;Resource Sharing;Resources;Role;sample archive;Sampling;Secure;Services;single cell genomics;single cell sequencing;single-cell RNA sequencing;Standardization;Statistical Data Interpretation;Structure;Surveys;System;Techniques;Technology;Testing;Tissue Banks;tool;transcriptome sequencing;translational cancer research;translational genomics;Translational Research;tumor;Universities;web page;Work

PROJECT_TITLE: Analytical and Translational Genomics


PI_NAMEs: GRADY, WILLIAM MALLORY (contact)

PROJECT_TERMS: adenoma;Administrative Coordination;Architecture;Basic Science;Biology;Cancer Biology;cancer genomics;Cancer Intervention and Surveillance Modeling Network;Collaborations;Communication;Communities;Data Analyses;Data Commons;Data Coordinating Center;data dissemination;data harmonization;data sharing;data submission;Education;Funding;Goals;gut microbiome;Industrialization;industry partner;innovation;Institution;Investigation;meetings;member;Mission;operation;organizational structure;Pathology;Process;Productivity;programs;protocol development;Rana;Research;Research Personnel;Structure;System;Teleconferences;Tissues;Translational Research;United States National Institutes of Health


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Precision Medicine;Prevention

PROJECT_TERMS: Aberrant DNA Methylation;adenoma;Architecture;Atlases;biobank;Biological;Biological Markers;Biological Models;Biology;cancer prevention;cell type;Cells;Classification;Clinical;cohort;Collection;Colon;colon cancer patients;Colonic Adenoma;colorectal cancer prevention;colorectal cancer screening;Complex;deep sequencing;Development;digital;DNA Methylation;DNA Sequence Alteration;driver mutation;dysbiosis;Ecosystem;Environment;Epigenetic Process;Epithelial Cells;Epithelium;Evaluation;Fibroblasts;Fostering;Gene Mutation;Gnotobiotic;gut microbiome;gut microbiota;Histologic;Indolent;Infrastructure;insight;Lesion;Malignant Neoplasms;Mediating;Methods;methylation pattern;methylome;Microbe;microbiome;microbiota;Modeling;Molecular Profiling;Monitor;multiple omics;Oncogenic;Organism;Outcome;Patients;permissiveness;personalized biomarkers;Play;premalignant;Process;programs;prospective;recruit;Research Personnel;Resolution;Resources;risk prediction;risk stratification;Role;Sampling;senescence;senescence associated secretory phenotype;Testing;tissue biomarkers;Tissues;Tumor Promotion;tumor-immune system interactions

PROJECT_TITLE: Comprehensive atlas of advanced adenomas and their surrounding primed colon: A multi-omics evaluation and clinical impact assessment


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: EDWARDS, JEREMY S (contact)

PROJECT_TERMS: Access to Information;anti-cancer research;Applications Grants;Awareness;Bioinformatics;bioinformatics pipeline;bioinformatics resource;Bioinformatics Shared Resource;bioinformatics tool;Cancer Center;Cancer Center Support Grant;cancer genome;cancer genomics;cheminformatics;Collaborations;Complex;Comprehensive Cancer Center;Computer software;computing resources;cost effective;Custom;Data;Data Analyses;data platform;Data Set;Databases;Dedications;design;Doctor of Philosophy;Drug Targeting;Education;Engineering;Equipment;Faculty;falls;Fostering;Funding;genome sequencing;genomic data;genomic tools;Genomics;Goals;Grant;high throughput analysis;high-throughput drug screening;improved;Informatics;innovation;innovative technologies;instrumentation;Knowledge;Knowledge Management;lectures;Legal patent;Link;Malignant Neoplasms;Manuscripts;meetings;member;Methodology;Methods;Modeling;multidimensional data;NCI Center for Cancer Research;New Mexico;news;Newsletter;novel;Nucleic Acids;Oncogenes;patient engagement;Pharmaceutical Preparations;Play;population based;programs;Publications;Publishing;Quality Control;recruit;Research;Research Design;Research Personnel;Reservations;Resource Sharing;Resources;RNA;Role;Schools;secondary analysis;Services;skills;Students;Techniques;Technology;tool;United States National Institutes of Health;Universities;Update;Variant;web page;Work

PROJECT_TITLE: Bioinformatics


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Microbiome;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: HALBERG, RICHARD BROTT (contact)

PROJECT_TERMS: Acceleration;adenoma;Affect;APC gene;APC mutation;Architecture;cancer risk;Cancerous;Carcinoma;Cells;Cessation of life;Chemopreventive Agent;Collection;Colon;design;Development;DNA sequencing;Epithelial Cells;Event;Fibroblasts;Gene Expression;Genes;Genetic;gut microbiome;high risk;Individual;innovation;KRAS2 gene;Label;Malignant Neoplasms;migration;Modernization;Molecular;mosaic;mouse model;Mus;mutant;Mutation;neoplastic cell;Normal tissue morphology;Paracrine Communication;Patients;Pharmaceutical Preparations;Pharmacologic Substance;PIK3CA gene;prevent;progenitor;Proliferating;Regulatory Pathway;Risk;Role;senescence;senescent cell;Signal Transduction;Solid;stem cells;Stromal Cells;success;Technology;Testing;Tissues;TP53 gene;transcriptomics;tumor;tumor heterogeneity;Tumor Stem Cells;Tumor Suppressor Genes;tumorigenic;United States

PROJECT_TITLE: Features of the early adenoma and adjacent colon that drive progression: the role of mutation burden in normal tissue, senescent cells, and tumor clonal architecture


NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: GILLETTE, JENNIFER  (contact)

PROJECT_TERMS: Adopted;animal imaging;Animal Model;anti-cancer research;Applications Grants;Automobile Driving;Basic Cancer Research;Basic Science;Biological;Cancer Center;Cancer Center Support Grant;Cell Separation;Cells;Clinical;Cloning;Collaborations;Complex;Computer software;Contracts;cost effective;cost estimate;Cytometry;Data Analyses;Data Set;Deposition;Development;Doctor of Philosophy;drug discovery;Education;Equipment;Experimental Designs;Faculty;Feedback;Fees;Flow Cytometry;Flow Cytometry Shared Resource;Fluorescence;Funding;Goals;Growth;Heterogeneity;humanized mouse;improved;Individual;innovation;innovative technologies;Institution;Instruction;instrumentation;interest;International;Interruption;Licensing;Link;Malignant Neoplasms;meetings;member;Methodology;Mission;Modernization;Molecular;mouse model;New Mexico;new technology;Newsletter;Online Systems;Outcome;Patients;Peer Review Grants;Play;Population;Price;programs;protein expression;Publications;Research;Research Personnel;Reservations;Resource Sharing;Resources;Role;Sampling;Science;Services;single cell analysis;Societies;Speed;Sterility;Structure;System;Techniques;Technology;Therapeutic;tool;Training;transcriptome sequencing;translational cancer research;Translational Research;tumor;Universities;Update;web page;webinar;Work

PROJECT_TITLE: Flow Cytometry


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Prevention

PI_NAMEs: DEY, NEELENDU  (contact)

PROJECT_TERMS: adenoma;Architecture;Area;Automobile Driving;Bacteria;Basic Science;Behavior;Biology;Cells;clinical care;Collaborations;Colon;Colonic Adenoma;Colonoscopy;Colorectal;Colorectal Adenoma;Colorectal Cancer;colorectal cancer prevention;Data;deep sequencing;design;experimental study;Fibroblasts;Fusobacterium nucleatum;Future;Genes;Genetic;genomic signature;Gnotobiotic;gut bacteria;gut microbes;gut microbiome;Health;host microbiome;Human;Image;In Situ;Individual;individualized prevention;Indolent;insight;Intervention;Knowledge;Lesion;Link;Longitudinal cohort;Machine Learning;Mediating;Mediation;Metagenomics;microbiome;Modeling;Molecular;Molecular Profiling;Monitor;Mus;Natural History;novel;Oncogenic;Organoids;pathobiont;Role;screening;senescence;senescence associated secretory phenotype;Testing;Tissues;Translations;tumor;tumorigenesis;tumorigenic;Up-Regulation;Visual

PROJECT_TITLE: The gut microbiome, interactions with primed colon states, and effects on adenoma formation and progression


PI_NAMEs: LIDKE, DIANE  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Algorithmic Analysis;anti-cancer research;assay development;Award;Basic Cancer Research;Biological Assay;Biophysics;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Catchment Area;cell behavior;cell fixing;Cell Physiology;Cells;Cellular biology;cellular imaging;Collaborations;Color;Comprehensive Cancer Center;Computer software;cost effective;cost effectiveness;Development;Doctor of Philosophy;Education;Educational Activities;Ensure;Equipment;experience;Faculty;Feedback;Fluorescence;fluorescence imaging;Fluorescence Microscopy;Future;Goals;graduate student;Grant;Human Resources;Image;Image Analysis;imaging capabilities;imaging modality;imaging platform;Imaging Techniques;Imaging technology;innovation;instrument;instrumentation;Investigation;Laboratories;lectures;light microscopy;Malignant - descriptor;meetings;member;meter;Methods;Microscope;microscopic imaging;Microscopy;Molecular and Cellular Biology;molecular imaging;multimodality;nanoscale;NCI Center for Cancer Research;New Mexico;new technology;Newsletter;novel;Oncogenic;Online Systems;particle;Peer Review Grants;Phase;Pilot Projects;Postdoctoral Fellow;Preparation;programs;prospective;protein protein interaction;Publications;quantitative imaging;Research;Research Personnel;Reservations;Resistance;Resource Sharing;Resources;Sampling;Schedule;Services;Signal Transduction;single molecule;Solvents;superresolution imaging;Surveys;System;Techniques;Technology;technology development;temporal measurement;Tissue imaging;Tissues;Training;translational cancer research;ultra high resolution;Universities;University resources;Update;Visualization;web page;web site

PROJECT_TITLE: Fluorescence Microscopy and Cell Imaging


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Data Science;Digestive Diseases;Genetics;Human Genome;Microbiome

PI_NAMEs: MATKOWSKYJ, KRISTINA A. (contact)

PROJECT_TERMS: adenoma;analytical tool;Architecture;Basic Science;Big Data;Biometry;Cells;Chromosome Mapping;Clinical;clinically significant;Code;cohort;Collection;Colon;Colonic Adenoma;Communication;Communities;Complex;Computed Tomographic Colonography;Data;Data Analyses;data harmonization;Data Set;data sharing;Data Storage and Retrieval;data visualization;Databases;design;digital;Elements;Ensure;exome sequencing;Faculty;Fred Hutchinson Cancer Research Center;Gene Expression;Genomics;gut microbiome;Histology;Histopathology;Human;human tissue;Image;Immunohistochemistry;innovative technologies;Institution;interoperability;Investments;Knowledge;Laboratories;Lesion;Longitudinal cohort;Medicine;Metagenomics;methylomics;Molecular;Molecular Profiling;Molecular Target;multidimensional data;multiple omics;Mus;nano-string;next generation sequencing;novel;Nucleic Acids;Oncology;Pathology;Patient Care;Patients;Pattern;Polyps;Population;programs;Protein Analysis;protein expression;Radiology Specialty;Research;Research Personnel;Resolution;Resources;Sampling;Science;serial imaging;Services;single cell sequencing;Site;Specimen;spectrograph;statistics;Structure;success;Sum;System;Techniques;Technology;Tissues;tool;transcriptomics;translational goal;translational medicine;Translational Research;Universities;Washington;Wisconsin

PROJECT_TITLE: Translational Pathology and Data Analysis Core (TPDAC)


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

PHR: NARRATIVE – Project 1  Our proposed research will expand the role of all primary care team members and support the use of standing orders in HPV vaccination. The Program Project will disseminate findings via the Announcement Approach Training Intervention Package, publications, and hpvIQ.org.

PI_NAMEs: BREWER, NOEL TODD (contact)

PROJECT_TERMS: Address;Adolescent;Age;Area;arm;cancer prevention;Child;Clinic;Clinic Visits;Clinical;Communication;cost;cost effectiveness;Cost Effectiveness Analysis;Data;Development;Educational Intervention;Educational process of instructing;Educational workshop;Genetic Complementation Test;Healthcare;Healthcare Systems;Hour;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Immunization;implementation determinants;implementation intervention;implementation outcomes;improved;informant;innovation;Intervention;intervention program;Interview;Language;Laws;Medical;meetings;member;Mississippi;Missouri;Motivation;Nurses;Outcome;Parents;Participant;patient population;Patients;Persuasive Communication;pilot test;primary care clinic;primary care team;Program Research Project Grants;programs;Provider;Publications;Randomized;randomized, clinical trials;Recommendation;Registered nurse;Research;Role;Rural;rural area;rural health clinic;rural patients;rurality;Sampling;Series;skills;Slide;Specific qualifier value;support tools;Surveys;System;Testing;Texas;Training;Training Programs;training project;Trust;Update;uptake;vaccine acceptance;vaccine delivery;Vaccines;Work

PROJECT_TITLE: IMPACT Project 1 – The impact of standing orders support on HPV vaccine communication and uptake


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: PANKRATZ, V. SHANE  (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Area;Basic Science;Bioinformatics Shared Resource;Biometry;Biostatistics Shared Resource;Cancer Center;Cancer Center Support Grant;Catchment Area;Clinical;clinical development;Clinical Research;Clinical Research Protocols;clinical trial analysis;Clinical Trials;Collaborations;Communities;computer program;Computer software;Conduct Clinical Trials;cost effective;Data;Data Analyses;data quality;design;Development;Doctor of Philosophy;Education;Educational workshop;Ensure;Environmental Exposure;experience;experimental study;Extramural Activities;Faculty;Funding;genomic data;Genomics;Goals;Grant;high dimensionality;innovation;interest;Investigational Therapies;Investments;Knowledge;Knowledge acquisition;Laboratories;Leadership;lectures;Manuscripts;meetings;member;Methodology;Modeling;Monitor;Monitoring Clinical Trials;New Mexico;Online Systems;patient safety;Patients;Peer Review Grants;Population;population based;Population Research;Population Study;Preparation;programs;Protocols documentation;Publications;Publishing;Reporting;Research;Research Activity;Research Design;Research Personnel;Research Priority;Research Project Grants;research study;Research Support;Resources;Safety;Services;skills;Statistical Data Interpretation;Statistical Methods;Summary Reports;Techniques;Technology;tool;translational cancer research;translational genomics;Translational Research;Universities;web page;Work;Writing

PROJECT_TITLE: Biostatistics


NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: MCCANCE, DENNIS J. (contact)

PROJECT_TERMS: Accreditation;Advanced Malignant Neoplasm;Affect;Aliquot;American;American Indians;animal tissue;anti-cancer research;Archives;Basic Cancer Research;Basic Science;biobank;Biological Specimen Banks;Blood;Blood specimen;Bone Marrow;Budgets;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer genome;cancer health disparity;cancer therapy;Catchment Area;Certification;Clinical;Clinical Research;Clinical Sciences;Collection;college;Communication;community engagement;Community Outreach;Computerized Medical Record;Consent;cost effective;COVID-19 pandemic;Cryopreserved Cell;Data;Databases;Date of birth;Dedications;Diagnosis;Diagnostic;digital imaging;DNA;Doctor of Philosophy;Education;electronic data;Equipment;Ethnic Origin;Ethnic Population;evidence base;experience;Faculty;falls;Formalin;Freezing;Funding;genome sequencing;Germ Lines;Goals;Grant;Guidelines;Hematologic Neoplasms;Hispanic;Hispanic Populations;Hospitals;Human;human tissue;Image;Immunofluorescence Immunologic;Information Systems;innovation;Institutional Review Boards;Ischemia;Leadership;Link;Malignant Neoplasms;Medical;meetings;member;Methodology;Methods;Names;Native Americans;neoplasm registry;New Mexico;Normal tissue morphology;Not Hispanic or Latino;Nursing Faculty;Outcome;Outreach Research;Pamphlets;Paraffin Embedding;Pathologist;Pathology;patient engagement;Patient-Focused Outcomes;Patients;Peer Review Grants;Plasma;Population;Population Heterogeneity;Population Sciences;Precision Medicine Initiative;Procedures;Process;programs;Publications;Race;Reporting;repository;Research;Research Personnel;Resource Sharing;Resources;RNA;Saliva;sample collection;Sampling;Serum;Services;Slide;Source;Specimen;Stains;System;Technology;Tissue Banks;Tissue Expansion;Tissue Stains;Tissues;Training Programs;translational cancer research;Translational Research;tumor;Tumor Bank;tumor registry;Universities;Update;Virginia;web page;web site;Whole Blood;Work

PROJECT_TITLE: Human Tissue Repository and Tissue Analysis


PI_NAMEs: STEINKAMP, MARA PEASE (contact)

PROJECT_TERMS: Adopted;Advanced Malignant Neoplasm;Animal Experimentation;Animal Husbandry;animal imaging;Animal Model;Animals;anti-cancer research;Autopsy;Basic Cancer Research;Basic Science;Bone Marrow Purging;cancer cell;Cancer Center;Cancer Center Support Grant;cancer imaging;cancer therapy;Caring;Catchment Area;clinically relevant;Collaborations;cost;cost effective;design;Doctor of Philosophy;Education;Engraftment;Equipment;experience;Experimental Designs;Faculty;Funding;Goals;Grant;Health Sciences;humanized mouse;Image;image translation;imaging capabilities;imaging probe;imaging system;Immune system;implantation;improved;in vivo;in vivo imaging;in vivo imaging system;in vivo optical imaging;information organization;innovation;insight;instrument;instrumentation;Internet;irradiation;Label;Laboratories;Laboratory Animal Production and Facilities;lectures;lentivirally transduced;Link;Luciferases;Magnetic Resonance Imaging;Manufacturer;meetings;member;Methodology;Modeling;Monitor;mouse model;Mus;nanoparticle;NCI Center for Cancer Research;New Mexico;new technology;Newsletter;novel;novel therapeutics;Online Systems;Organism;patient derived xenograft model;Peer Review;Peer Review Grants;Pharmaceutical Preparations;Pharmacotherapy;Population;Positron-Emission Tomography;pre-clinical;pre-clinical research;preclinical study;programs;Protocols documentation;Publications;Reporter;Reporting;Research;Research Design;Research Personnel;Reservations;Resource Sharing;Resources;Roentgen Rays;Role;Schedule;Services;Students;System;Techniques;Technology;Testing;Training;Training and Education;translational cancer research;Translational Research;treatment response;tumor;Tumor Burden;tumor growth;tumor xenograft;ultrasound;Universities;Update;web page;web site;Work

PROJECT_TITLE: Animal Models & Imaging


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Prevention;Primary Health Care;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

PHR: NARRATIVE – Project 2  Our goal is to rigorously test promising alternatives to motivate providers to improve human papillomavirus (HPV) vaccination communication and HPV vaccination rates in healthcare systems. The proposed randomized clinical trial will demonstrate whether and how financial incentives improve provider communication and increase vaccine uptake to achieve HPV vaccination goals.

PI_NAMEs: TROGDON, JUSTIN  (contact)

PROJECT_TERMS: Address;Adolescent;Adopted;Adoption;arm;Behavior;Behavioral;behavioral economics;cancer type;Clinic;Cognition;Communication;Contracts;cost;Cost Analysis;cost effective;Cost Effectiveness Analysis;Data;design;Educational Intervention;Educational workshop;Effectiveness;Electronic Health Record;Feedback;financial incentive;Frequencies;Goals;Healthcare Systems;Hour;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation intervention;implementation outcomes;improved;Incentives;Incidence;informant;innovation;insight;Intervention;intervention program;Interview;Learning;member;payment;Pediatrics;peer;Perception;Performance;Policies;primary care team;Program Research Project Grants;programs;Provider;provider communication;Public Health;Quality of Care;Randomized;randomized, clinical trials;Recommendation;Reporting;Research;response;rural area;rurality;Structure;Surveys;System;Testing;tool;Training;training opportunity;Training Programs;training project;United States;uptake;usability;vaccine acceptance

PROJECT_TITLE: IMPACT Project 2 – The impact of clinic-level financial incentives on HPV vaccine communication and uptake


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities

PI_NAMEs: GUEST, DOLORES  (contact)

PROJECT_TERMS: Address;Advisory Committees;anti-cancer research;Area;Basic Cancer Research;Basic Science;behavior measurement;Behavioral Sciences;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research;Catchment Area;Clinic;Clinical;Clinical Trials;Communication;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Consultations;Continuity of Patient Care;cost effective;cost estimate;Data Analyses;Data Collection;data management;Database Management Systems;Device or Instrument Development;Doctor of Philosophy;Education;Ensure;Equipment;Equipment and Supplies;ethnic diversity;experience;Extramural Activities;Faculty;Funding;Goals;Grant;Health Services Accessibility;innovation;Intake;Intervention Trial;Lead;Leadership;Libraries;Malignant Neoplasms;meetings;member;Methodology;NCI Center for Cancer Research;New Mexico;Observational Study;Peer Review;Peer Review Grants;personalized approach;Pilot Projects;Policies;Population;Population Sciences;Principal Investigator;Procedures;Process;programs;Protocols documentation;racial diversity;rapid growth;recruit;Reporting;Research;research and development;Research Design;Research Methodology;Research Personnel;research study;Research Support;Resource Allocation;Resource Sharing;Resources;Role;Services;Site Visit;Structure;Surveys;System;Techniques;Technology;Training;translational cancer research;Translational Research;Travel;Universities;web page;Work;working group

PROJECT_TITLE: Behavioral Measurement and Population Science


NIH_SPENDING_CATS: Cancer;Clinical Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Services;Immunization;Infectious Diseases;Prevention;Primary Health Care;Rural Health;Sexually Transmitted Infections;Vaccine Related

PHR: NARRATIVE – Project 3  The proposed trial will test a new way to help healthcare systems improve HPV vaccination. We will train clinical champions to deliver HPV vaccine communication workshops to primary care teams in their own systems. We expect that this champion-delivered intervention will improve HPV vaccination and build capacity for communication training in healthcare systems.

PI_NAMEs: GILKEY, MELISSA B (contact)

PROJECT_TERMS: Address;Adolescent;Age;arm;Certification;Clinic;Clinical;clinical training;Communication;communication behavior;comparative cost effectiveness;compare effectiveness;comparison intervention;cost;cost effectiveness;Data;data sharing;Dose;Educational Intervention;Educational workshop;Electronic Health Record;Family Physicians;follow-up;Goals;Healthcare Systems;Hour;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;implementation measures;implementation outcomes;improved;innovation;Intervention;intervention cost;intervention delivery;intervention program;Interview;Knowledge;Modeling;novel strategies;Outcome;Participant;pediatrician;Physicians;preference;prevent;Primary Care;Primary Care Physician;primary care team;primary outcome;Program Research Project Grants;programs;Protocols documentation;Provider;Qualitative Research;Randomized;randomized, clinical trials;Recommendation;Research;Rural;rural area;rural dwellers;scale up;Series;Surveys;System;Testing;Training;Training Activity;Training Programs;training project;uptake;vaccination outcome;West Virginia;Wisconsin;Work

PROJECT_TITLE: IMPACT Project 3 – Engaging clinical champions to improve HPV vaccine communication and uptake in healthcare systems


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Prevention;Primary Health Care;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

PHR: NARRATIVE – Project 4  Our goal is to facilitate the adoption of promising HPV vaccine communication interventions. This study will examine the budget impact, cost-effectiveness, and population outcomes of HPV vaccine communication interventions in rural and nonrural communities, and aid decision makers with a decision support tool. We expect generated evidence to accelerate the uptake of promising interventions to improve HPV vaccination.

PI_NAMEs: OZAWA, SACHIKO  (contact)

PROJECT_TERMS: Acceleration;Address;Administrator;Adoption;Advanced Malignant Neoplasm;Affect;Area;budget impact;Calibration;cancer prevention;Clinical;Communication;Communities;comparative;contextual factors;cost;cost effectiveness;County;Data;Decision Aid;Decision Making;Educational Intervention;Effectiveness;evidence base;Evidence based intervention;Feedback;Geography;Goals;Health;Health system;Healthcare Systems;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation context;implementation intervention;implementation outcomes;improved;innovation;Intervention;intervention cost;intervention program;Intervention Studies;Interview;Malignant Neoplasms;member;Methods;Modeling;models and simulation;motivational enhancement therapy;North Carolina;novel;Online Systems;Outcome;Pattern;Population;population health;prevent;primary care team;Program Research Project Grants;programs;Provider;provider communication;Research;Rural;rural area;rural setting;Sampling;Science;Social Environment;Structure;support tools;Surveys;Testing;tool;Training;Training Programs;training project;Translating;transmission process;uptake;usability;Vaccination;Visualization;web site;Wisconsin;Work

PROJECT_TITLE: IMPACT Project 4 – Budget impact, cost-effectiveness, and population outcomes of interventions to improve HPV vaccine communication and uptake in rural and nonrural communities


NIH_SPENDING_CATS: Cancer;Clinical Research;HPV and/or Cervical Cancer Vaccines;Health Services;Immunization;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Vaccine Related

PHR: NARRATIVE – Administrative Core Not applicable.

PROJECT_TERMS: Acceleration;Address;cancer prevention;Collaborations;Communication;Communication Programs;Complex;Data;Development;Dissemination and Implementation;Elements;Ensure;Ethics;Fostering;Foundations;Funding;Goals;Grant;Healthcare Systems;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;improved;Individual;Infrastructure;innovation;Institution;Intervention;intervention program;Investments;Lead;Leadership;meetings;Monitor;multidisciplinary;operation;Phase;Pilot Projects;Primary Care;primary care team;Principal Investigator;Process;Program Research Project Grants;programs;Provider;public health research;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;research study;Research Training;Resource Sharing;Resources;response;Safety;Scientist;synergism;Testing;Training;Training Programs;training project;uptake;Vaccination;Work

PROJECT_TITLE: Administrative Core – Improving Provider Announcement Communication Training (IMPACT)


NIH_SPENDING_CATS: Cancer;Clinical Research;Cost Effectiveness Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Vaccine Related

PHR: NARRATIVE – Intervention Core  The Intervention Core will support the efforts of 4 research projects to conduct high-quality evaluations of Announcement Approach Training interventions. We will accomplish this goal by coordinating clinical expertise, preparing training materials and facilitators, harmonizing key measures, and sharing study products.

PROJECT_TERMS: Academia;Address;Adolescent;Advocacy;Advocate;Behavioral Sciences;cancer prevention;Childhood;Clinic;Clinical;clinical practice;clinical research site;Collaborations;Communication;cost;cost effectiveness;Cost Effectiveness Analysis;Data;Data Collection;data sharing;design;Discipline of Nursing;Educational Curriculum;Educational Intervention;Educational workshop;Effectiveness;Effectiveness of Interventions;Ensure;Environment;Evaluation;Evidence based intervention;Family;Family Practice;Feedback;financial incentive;Future;Goals;health economics;Health Policy;Health Resources;Healthcare Systems;Hour;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation barriers;implementation evaluation;implementation facilitation;implementation measures;implementation outcomes;improved;Instruction;Intervention;intervention delivery;Malignant Neoplasms;Measures;Medical;Medicine;meetings;Monitor;multidisciplinary;Nurse Practitioners;Nurses;Parents;Patients;Pediatrics;Performance;Physician Assistants;Physicians;Policies;Population;Preparation;Preventive care;Primary Care;primary care practice;primary care team;Procedures;Production;program dissemination;programs;Provider;Public Health;randomized, clinical trials;Recommendation;recruit;Research;Research Project Grants;research to practice;rural area;Safety;social media;Social Sciences;Speed;Testing;therapy development;tool;tool development;Trainers Training;Training;Training Programs;Translations;trend;Update;Vaccination;web site;Work;Youth

PROJECT_TITLE: Intervention Core - Improving Provider Announcement Communication Training (IMPACT)


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;HPV and/or Cervical Cancer Vaccines;Health Services;Immunization;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Vaccine Related

PHR: NARRATIVE – Data Core The Data Core will centralize data-related services across research projects for the P01 Program Project. The Data Core’s functions include managing a national primary care team survey, cleaning and standardizing effectiveness data across research projects and providing statistical support for randomization and analysis.

PI_NAMEs: QUEEN, TARA L (contact)

PROJECT_TERMS: Address;Adolescent;arm;Biostatistics Core;budget impact;cancer prevention;Clinic;Clinical Trials Design;Cluster Analysis;Cluster randomized trial;Collaborations;Communication;Complex;Comprehensive Cancer Center;Consult;cost effectiveness;Cost Effectiveness Analysis;Cost Savings;Data;data acquisition;Data Analyses;data cleaning;data dictionary;data management;data quality;Data Set;data sharing;data standards;design;econometrics;Effectiveness;electronic health data;Electronic Health Record;Ensure;Health;Healthcare Systems;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;improved;Incidence;innovation;Intervention;intervention program;large datasets;Market Research;Measures;Medical;member;Methodology;Mission;Modeling;North Carolina;Nurse Practitioners;Physician Assistants;Physicians;power analysis;Primary Care;primary care team;Professional Role;Program Research Project Grants;programs;Protocols documentation;Provider;provider communication;Psychologist;Public Health;Randomized;randomized trial;randomized, clinical trials;Registered nurse;Research;Research Design;Research Personnel;Research Project Grants;Research Training;Resources;rural area;Sampling;Services;Standardization;standardize measure;Statistical Data Interpretation;Stream;Structure;Survey Methodology;Surveys;Testing;Training;training opportunity;Training Programs;trial planning;Universities;usability;Vaccination;vaccination outcome;Vaccine Clinical Trial;vaccine distribution

PROJECT_TITLE: Data Core – Improving Provider Announcement Communication Training (IMPACT)


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: Project Narrative This SPiRE pilot will provide foundational data paving the way for treatment enhancements tailored for Veterans with obsessive-compulsive spectrum disorders or an 'overcontrolled' temperament—a high-risk, underserved group vulnerable to suicide. Our longer-term goal is to enhance diagnostic precision and treatment effectiveness for veterans at elevated suicide risk due to these specific conditions.

PI_NAMEs: BARREDO, JENNIFER LEIGH (contact)

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Aggressive behavior;Anger;Behavior;Brain;burnout;Caring;Clinical;Cognitive;cognitive neuroscience;cognitive rigidity;cohort;comorbidity;Data;design;Development;Diagnostic;Discipline;discounting;Disease;disorder risk;Doctor of Philosophy;emotion regulation;Emotional;Empathy;Evaluation;Exhibits;expectation;FDA approved;feasibility testing;flexibility;Functional Magnetic Resonance Imaging;Goals;high risk;high standard;Impairment;improved;Individual;individualized medicine;Informal Social Control;innovation;instrument;Interview;Knowledge;Learning;Link;Magnetic Resonance Imaging;Measures;Mental Depression;Mental Health;Methods;Military Personnel;Modeling;Monitor;neural correlate;neuroregulation;noninvasive brain stimulation;Obsessive compulsive behavior;Obsessive-Compulsive Personality;Occupational;Pathology;Pathway interactions;personalized diagnostics;personalized medicine;Phenotype;Pilot Projects;Positioning Attribute;Post-Traumatic Stress Disorders;precision medicine;Predisposition;Protocols documentation;psychosocial;Psychotherapy;Quality of life;recruit;reducing suicide;Rehabilitation therapy;remote monitoring;Research;research and development;response;Reversal Learning;Sampling;self-compassion;Signal Transduction;skill acquisition;skills;social attachment;social deficits;Social Functioning;Social support;Stress;suicidal;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Surface;Taxes;Temperament;Therapeutic;trait;Trauma;trauma exposure;traumatic stress;Treatment Effectiveness;treatment optimization;Underserved Population;Validation;Veterans;Vulnerable Populations

PROJECT_TITLE: Pathways to Hope: Pilot fMRI Study of OCPD and Suicide Risk in Trauma-Exposed Veterans

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: Repeated mild traumatic brain injuries and prolonged opioid use are independent and synergizing risk factors for the development of numerous health problems including PTSD and substance use disorders. This project will evaluate whether blast exposure and prolong fentanyl consumption have additive effects on subsequent anxiety and fentanyl self-administration in mice, and whether this can be inhibited by a novel drug that inhibits the FKBP5 system and normalized glucocorticoid signaling.

PI_NAMEs: NEUMAIER, JOHN F (contact)

PROJECT_TERMS: Afghanistan;alcohol exposure;Anhedonia;Animal Testing;Animals;antagonist;Anxiety;anxiety reduction;anxiety-like behavior;Award;Behavior;behavior test;Behavioral;blast exposure;Brain;Brain region;Catheterization;Chronic;chronic pain;Cognitive;cognitive change;combat zone;comorbidity;Consumption;Corpus striatum structure;design;Development;Disease;Dose;drug seeking behavior;Emotional;emotional behavior;experience;Experimental Designs;experimental study;Exposure to;Feedback;Female;Fentanyl;fentanyl exposure;fentanyl seeking;fentanyl self-administration;fentanyl use;FK506 binding protein 5;gene environment interaction;Gene Expression;Genes;Genetic;Genetic Polymorphism;Glucocorticoid Receptor;Glucocorticoids;Goals;Health;hormonal signals;Implant;Impulsivity;Individual;inhibitor;Injury;innovation;Interruption;Iraq;knowledge base;Life;Life Experience;life span;male;Medical;Microglia;mild traumatic brain injury;Modeling;Molecular Chaperones;Mus;negative emotional state;Neurons;neuropsychiatric disorder;novel;novel therapeutic intervention;novel therapeutics;Opioid;opioid exposure;opioid use;opioid use disorder;Oral;osmotic minipump;Outcome;Pain;Pilot Projects;Population;Post-Traumatic Stress Disorders;preclinical study;pressure;Procedures;Proteins;Protocols documentation;Publishing;receptor sensitivity;Relapse;Reporting;Research Design;Risk;Risk Factors;Role;Runaway;Saline;Self Administration;Serotonin;Signal Transduction;small molecule;small molecule inhibitor;Stress;stressor;Substance abuse problem;substance use;Substance Use Disorder;synergism;System;Testing;Therapeutic;Time;tool;Translating;translational pipeline;Tube;Variant;Veterans;War

PROJECT_TITLE: The impact of prolonged fentanyl exposure after mild traumatic brain injury on stress associated behaviors


PHR: High rates of Veteran suicide remain a tragedy. Rates of Veteran suicide have not decreased for 10 years, despite the best efforts of the field. Those interventions that do exist have only modest effects, which are simply insufficient for the magnitude of the problem. This proposal will combine two treatments – brief cognitive behavioral therapy (BCBT) and repetitive transcranial magnetic stimulation (TMS). Both of these interventions can reduce suicide and are available at Veterans Affairs Medical Centers across the country, yet to date no one has combined these therapies. This proposal will test the effect of this combination, and, if successful, will lead to a novel yet implementable new treatment to reduce Veteran suicide.

PI_NAMEs: PHILIP, NOAH STEPHEN;PRIMACK, JENNIFER MARIE (contact)

PROJECT_TERMS: Address;Admission activity;Aftercare;associated symptom;Behavior;Blinded;Brain region;brief intervention;Cessation of life;Clinical;Cognitive Therapy;Combined Modality Therapy;comorbidity;Conduct Clinical Trials;Consultations;cost;Country;Diabetes Mellitus;Diagnosis;Disease;Dissemination and Implementation;Effect Modifiers (Epidemiology);Effectiveness;efficacious treatment;efficacy evaluation;Enrollment;Feeling suicidal;follow-up;Gender;Goals;Growth;Health Priorities;Healthcare Systems;high risk;hospital readmission;Hospitalization;Hospitals;improved;Induced Neurons;innovation;inpatient psychiatric treatment;Inpatients;Intervention;Left;magnetic field;Major Depressive Disorder;Mediating;Mediator;Medical center;Mental Depression;Military Personnel;Modality;Modeling;mortality;novel;operation;optimal treatments;Outcome;Participant;Patients;Pharmaceutical Preparations;Physiologic pulse;Post-Traumatic Stress Disorders;Prefrontal Cortex;programs;psychiatric symptom;psychosocial;Psychotherapy;Randomized;Randomized, Controlled Trials;readmission rates;reduce symptoms;reducing suicide;repetitive transcranial magnetic stimulation;Sampling;secondary analysis;secondary outcome;Severities;side effect;statistics;suicidal;suicidal behavior;suicidal individual;suicidal risk;Suicide;Suicide attempt;suicide attempter;Suicide prevention;suicide rate;System;Techniques;Testing;Time;Transcranial magnetic stimulation;Treatment Efficacy;Treatment outcome;treatment program;United States Department of Veterans Affairs;Veterans;Visit;Weight Gain;Work

PROJECT_TITLE: Combined Transcranial Magnetic Stimulation and Brief Cognitive Therapy to Reduce Veteran Suicide

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]