NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE As the aging US population increases and interventions for dementia become available for early stages, there is a growing need for low-cost sensitive tools to detect early cognitive decline in large samples. Digital phenotyping, a novel approach involving passive data collection from sensors on personal devices, such as smartwatches, could fill this gap to estimate early autonomic dysfunction and health behaviors associated with early cognitive decline. This project will examine the validity of several metrics from a commercially available and low-cost smartwatch in a diverse sample of older adults, which could have broad implications for health behavior monitoring, early detection of cognitive decline, and targeted interventions.

PI_NAMEs: HOLMQVIST, SOPHIA  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acceleration;Address;Adherence;aged;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Autonomic Dysfunction;Autonomic nervous system;Behavior;Behavior monitoring;Biometry;Blood;Bluetooth;Body mass index;Cellular Phone;Circadian Rhythms;Classification;Clinical;clinical diagnosis;clinical predictors;clinical risk;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive testing;Competence;Computer software;contextual factors;cost;Data;Data Collection;data integration;Dementia;Demographic Factors;Demographic Impact;demographics;Devices;Diagnosis;Diagnostic;digital;digital applications;digital phenotyping;Disease Progression;Early Diagnosis;Early Intervention;Education;Engineering;Ethics;Event;experience;Functional disorder;Future;Goals;Grouping;Health;Health behavior;Heart;Heart Rate;heart rate variability;Home environment;Hour;Impaired cognition;improved;Individual;Injury;Intervention;Knowledge;Life;Link;Literature;Measurement;Measures;Mental Depression;Methods;mild cognitive impairment;Modeling;Monitor;neuroimaging;Neuropsychological Tests;Neuropsychology;new technology;novel strategies;older adult;Outcome;Participant;Patient Self-Report;Patients;Pattern;Persons;Phenotype;Philadelphia;Physical activity;Physiological;Physiology;Polysomnography;Population;Population Heterogeneity;Populations at Risk;pre-clinical;Privacy;Procedures;protein biomarkers;Protocols documentation;Questionnaires;Race;racial diversity;recruit;Research;research clinical testing;Sampling;Sampling Studies;Schizophrenia;Secure;sensor;sex;side effect;Skin;Sleep;smart watch;Source;Statistical Methods;Stress;Surveys;Symptoms;Technology;Time;tool;Training;usability;Validation;vigorous intensity;Visit;wearable device

PROJECT_TITLE: Digital phenotypes from a low-cost smartwatch to inform early detection of Alzheimer's disease and related dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CLEVELAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Most cancer deaths result from spread of the primary tumor to distant sites, a process called metastasis, and patients with osteosarcoma are no exception. A major limitation in the development of targeted anti-metastatic therapies in osteosarcoma and other types of cancer is a lack of understanding of common biological contributors to this process. This study seeks to apply recent advances in the understanding of epigenetic gene regulation and OS biology to the study of lung metastasis.

PI_NAMEs: CHIN, DIANA  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 3-Dimensional;Adolescent;Affect;ATAC-seq;Binding;Biological;Biology;cancer type;Cell Line;Cells;Cessation of life;ChIP-seq;Chromatin;Chromatin Conformation Capture and Sequencing;Clinic;Clinical;clinically relevant;cohort;Competence;Complex;Copy Number Polymorphism;CRISPR interference;Databases;Dependence;Development;Diagnosis;Disease;disorder subtype;Distant;DNA Sequence Alteration;DNA Sequence Rearrangement;Enhancers;Epigenetic Process;epigenomics;Event;experimental study;Family;Gene Expression Regulation;Genes;Genome;Genomics;Goals;Growth;Harvest;Homeostasis;Human Cell Line;In Vitro;in vivo;individualized medicine;Inflammatory;inhibitor;Injections;Knock-in;Label;lens;Lung;lung colonization;MADH3 gene;MADH6 gene;Malignant Neoplasms;Mesenchymal Stem Cells;Metastatic Neoplasm to the Lung;Metastatic Osteosarcoma;metastatic process;Methylnitronitrosoguanidine;Modality;Modeling;Modification;mortality;Mutagens;Neoplasm Metastasis;novel;osteogenic;Osteosarcoma;Pathway interactions;patient derived xenograft model;Patients;primary bone cancer;Primary Lesion;Primary Neoplasm;Process;Prognosis;promoter;Property;Puma;risk stratification;RNA Polymerase II;Role;Serial Passage;Series;Signal Transduction;Site;Study models;System;Tail;targeted treatment;Testing;therapeutic target;Time;tool;transcription factor;transcriptome sequencing;tumor;Up-Regulation;Veins;Virus

PROJECT_TITLE: Epigenetic drivers of lung metastasis in osteosarcoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE People with obesity experience physiological, neural, and behavioral changes resulting in decreases in metabolic rate and increases in appetite, making weight-loss extremely challenging. As to why obesity pathology is persistent, my overarching hypothesis is that obesity strengthens feeding neural circuits driving the continued consumption of palatable foods in excess of caloric requirement. To inform novel therapies for producing robust weight loss, it is critical to understand the mechanism for how these foods alter neural circuits involved in initiating and sustaining pathological overeating behavior.

PI_NAMEs: WANG, JUSTIN G (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Acute;Affect;American;Animals;Area;Artificial Sweeteners;Automobile Driving;Behavior;Behavioral;Body Weight;Body Weight decreased;Brain;Calcium Signaling;Calories;Carbohydrates;Cardiovascular Diseases;cell type;Chronic;Clinical;comorbidity;Consumption;desensitization;Desire for food;Development;Diabetes Mellitus;Diet;diet-induced obesity;Dietary Fats;Disinhibition;Dissociation;Eating;Eating Behavior;Effectiveness;energy balance;Etiology;Excitotoxic lesion;Exhibits;experience;experimental study;Fatty acid glycerol esters;feeding;Feeding behaviors;Fiber;Food;food consumption;Fortified Food;Future;global health;Globus Pallidus;Goals;Head;hedonic;High Fat Diet;Human;Hyperphagia;Individual;Induced Neurons;insight;Intake;Intervention;Lesion;Life;lifestyle intervention;Macronutrients Nutrition;Malignant Neoplasms;Mediating;metabolic rate;Modeling;Motivation;Mus;neural;neural circuit;Neurons;novel therapeutics;Nutrient;Obese Mice;Obesity;obesity treatment;optogenetics;Overweight;Pathologic;Pathology;Persons;pharmacologic;Photometry;Physiological;Play;pleasure;Population;Prevalence;Process;Property;Proteins;Rattus;reduced food intake;Research;response;reward circuitry;Rewards;Rodent;Role;Satiation;Signal Transduction;Sodium Chloride;Somatostatin;Structure;sugar;System;Taste Perception;Testing;Therapeutic;therapeutic target;Water;Water consumption;Weight;Weight Gain;Work

PROJECT_TITLE: Interrogating Ventral Pallidal Circuits as a Therapeutic Target for Obesity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Biotechnology;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Endocrine Disruptors;Estrogen;Eye Disease and Disorders of Vision;Women's Health Research

ORG_CITY: ROCHESTER

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: NARRATIVE We will develop an in vitro salivary gland Sjögren’s syndrome (SS) tissue chip (SSTC) platform that will enable mechanistic studies of the disease pathogenesis which is predominately diagnosed in older woman. The proposed studies will investigate the effect of endocrine disrupting chemicals exposure on salivary gland function which may be important in the pathogenesis. The SSTC will enable future high throughput drug discovery studies. Currently there are no disease modifying drugs to treat SS patients.

PI_NAMEs: DELOUISE, LISA A (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Affect;Age;aged;Agonist;American;Androgen Receptor;associated symptom;Autoantibodies;Autoimmune Diseases;Calcium Signaling;Cell secretion;Cells;chemical association;Chemical Exposure;Chemicals;Chronic;Development;Diagnosis;differential expression;Disease;Dose;drug discovery;Endocrine;Endocrine Disruptors;Endocrine system;Engineering;environmental chemical;Environmental Risk Factor;Epigenetic Process;Estrogen Receptors;Etiology;Exhibits;Exocrine Glands;exposed human population;Exposure to;Extracellular Matrix;FDA approved;Female;Flow Cytometry;Functional impairment;Future;Genes;Genetic;Gland;Goals;Gonadal Steroid Hormones;Growth;high-throughput drug screening;Hormones;Human;immune cell infiltrate;Immune System Diseases;Immunohistochemistry;In Vitro;in vitro Model;in vivo;Incidence;Infiltration;Inflammatory;Libraries;Lymphocyte;lymphocyte proliferation;Lymphocytic Infiltrate;Lymphoid;male;Maternal Health;Measures;Microbubbles;Midlife women;mimetics;Modeling;Morphology;mouse model;Mus;novel;novel therapeutics;older women;Oral;Pathogenesis;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Pregnancy;prevent;Radiation-Protective Agents;receptor;Research;response;Role;Salivary Gland Tissue;Salivary Glands;Severities;Sex Differences;Sialadenitis;Sjogren's Syndrome;Spatial Distribution;Stains;success;Swelling;Symptoms;Syndrome;Technology;Testing;Time;tissue culture;Tissue Microarray;Tissues;transcriptome sequencing;Xerostomia

PROJECT_TITLE: Development of a salivary gland Sjögren's syndrome tissue chip platform

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARATIVE Eukaryotes depend on the faithful delivery of protein cargo to the correct subcellular location and perturbations to the factors directing these processes give rise to various human diseases. This project will characterize novel regulators of membrane trafficking, that function across a diverse range of cellular processes, using a combination of in vivo and in vitro experiments. The unique insights gained from this research will contribute to our fundamental understanding of membrane biology and will impact the treatment of disease.

PI_NAMEs: VIGNOGNA, RYAN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Architecture;Binding;Binding Proteins;Biochemical;Biochemistry;Biological;Biological Assay;Carrier Proteins;Cell Physiology;Cell Polarity;Cells;Cellular biology;Complex;Cryoelectron Microscopy;Data;Defect;Disease;Eukaryota;Eukaryotic Cell;Event;experimental study;Failure;Family;Fellowship;Fluorescence;Genetic;Goals;Golgi Apparatus;GTPase-Activating Proteins;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Homeostasis;human disease;Hydrolysis;Image;In Vitro;in vivo;insight;Knock-out;lipid metabolism;Lipids;Liposomes;live cell imaging;Location;member;Membrane;Membrane Biology;Microscopy;Molecular;Monitor;Monomeric GTP-Binding Proteins;Names;novel;Organelles;overexpression;Pathway interactions;Physiological;Positioning Attribute;Process;Property;Protein Family;protein function;protein protein interaction;Proteins;reconstitution;Regulation;Research;Role;Sorting;spatiotemporal;structural biology;Structure;Substrate Specificity;Surface;Techniques;trafficking;Vesicle;Visualization

PROJECT_TITLE: Discovery and characterization of a novel family of GTPase activating proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04B-S (20)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: MILWAUKEE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Despite the clear link between oxidative stress and cardiac disease, antioxidant treatments have been unsuccessful in lessening the high morbidity and mortality rates of cardiac disease alluding to the fact that increased oxidative stress may be secondary to disease pathology rather than causative. This application aims to assess whether upregulation of DRP1 contributes to the development of vascular endothelial dysfunction that subsequently progresses to cardiac damage, mitochondrial dysregulation, and metabolic dysfunction independent of increased formation of reactive oxygen species (ROS). The proposed studies use a novel rodent model to test the hypothesis that increased endothelial DRP1 leads to increased mitochondrial fragmentation, changes in metabolism, increased ROS production, and functional changes in the microcirculation and the heart.

PI_NAMEs: GUTIERREZ HUERTA, CRISTHIAN A (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Address;Antioxidants;arteriole;Biology;Blood;Blood Vessels;Cardiac;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cell Survival;Cellular biology;Cessation of life;Clinical;Clinical Trials;Complex;Coronary;Coronary Arteriosclerosis;Data;Death Rate;Development;Disease;Dynamin;ebselen;Echocardiography;Elements;Endothelial Cells;Endothelium;Environment;Event;Functional disorder;Glycolysis;Goals;Guanosine Triphosphate Phosphohydrolases;Heart;heart damage;Heart Diseases;heart function;heart metabolism;Human;Hydrogen Peroxide;Image;Impairment;improved;in vivo;in vivo evaluation;Incidence;Individual;inducible Cre;inhibitor;Intervention;Link;Lipid Peroxidation;lipid peroxidation inhibitor;Mediating;Membrane Lipids;Mesentery;Metabolic;Metabolic dysfunction;Metabolism;Microcirculation;Mitochondria;mitochondrial dysfunction;Modeling;Morbidity - disease rate;mortality;Myocardial dysfunction;Nitric Oxide;novel;Outcome;overexpression;Oxidative Phosphorylation;Oxidative Stress;oxidized lipid;Oxygen Consumption;Pathologic;Pathology;Patients;Phenotype;Physiological;Play;Prevalence;Process;Production;Proteins;Rat Transgene;Rattus;Reactive Oxygen Species;response;Rodent Model;Role;Rotenone;Secondary to;shear stress;Source;Stress;tempol;Testing;Therapeutic;Tissues;Transgenes;Up-Regulation;Vascular Diseases;vascular endothelial dysfunction;Vascular Endothelium;Vasodilation;Vasodilator Agents

PROJECT_TITLE: Critical Role of Endothelial DRP1 in regulating metabolic, microvascular, and cardiac function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (20)]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_CITY: KANSAS CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Bacteria belonging to the genus Streptococcus are responsible for various human diseases and phosphorylation of proteins plays a major role in bacterial physiology and virulence. In this study, we propose to unravel the role of arginine phosphorylation, a novel form of phosphorylation, in the pathophysiology of streptococci. Our study could potentially identify a novel bacterial arginine kinase and shed new molecular insights into how arginine phosphorylation modulates streptococcal proteome.

PI_NAMEs: BISWAS, INDRANIL  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Amino Acids;Anhydrides;Antibodies;Arginine;Aspartate;Bacillus;Bacillus subtilis;Bacteria;Bacterial Physiology;Biochemical;biological adaptation to stress;Biological Process;Cell Cycle Regulation;Cell division;Cell Physiology;Cells;Cellular Metabolic Process;chemical bond;Complex;Dental;Enterococcus;Enzymes;Esters;Firmicutes;Functional disorder;Funding Mechanisms;Gene Expression Regulation;Genes;genetic approach;Genetic Transcription;Genome;Genus Mycobacterium;Goals;Growth;high risk;Histidine;Homologous Gene;human disease;In Vitro;inorganic phosphate;insight;Lactococcus;Life Style;Mass Spectrum Analysis;Mediating;Medical;Microbial Biofilms;Modeling;Modification;Molecular;mutant;Myelin Basic Proteins;Nature;novel;Organism;pathogen;Pathogenesis;Pathway interactions;phosphoramidate;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Physiology;Play;Post-Translational Protein Processing;Process;programs;protein degradation;Protein Dephosphorylation;protein folding;Proteins;Proteome;Quality Control;Regulation;Reporting;Research;Ribosomal Proteins;Role;Serine;Signal Transduction;Staphylococcus aureus;Streptococcus;Streptococcus mutans;System;Taxonomy;Threonine;Transcription Repressor;Transcriptional Regulation;Translational Regulation;Translations;Tyrosine;Tyrosine Phosphorylation;Virulence;virulence gene;Western Blotting

PROJECT_TITLE: Exploring the function of novel arginine phosphorylation in streptococcal physiology


ADMINISTERING_IC: AI

ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The International Herpesvirus Workshop is the premier scientific meeting for herpesvirus researchers, and the only meeting with an interdisciplinary focus on all the major subfamilies of herpesviruses and all aspects of research from molecular biology to clinical studies.

PI_NAMEs: STREBLOW, DANIEL N (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Animal Disease Models;Animals;Anti-viral Agents;antiviral drug development;Atherosclerosis;Atmosphere;B-Lymphocytes;Blindness;Books;Budgets;Burkitt Lymphoma;Cells;Chickenpox;Clinical Research;Communities;Congenital Abnormality;cost;Cytomegalovirus;Data;deafness;Development;Disease;DNA biosynthesis;Educational workshop;Encephalitis;Ensure;Enzymatic Biochemistry;experience;Eye;Fees;Fertilization;Fostering;Funding;Gene Expression Regulation;gene therapy;Gene Transduction Agent;Genitalia;Genome;graduate student;Grant;Health;Herpes zoster disease;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;Human;Human Herpesvirus 2;Human Herpesvirus 4;Human Herpesvirus 8;Immune;Immune Evasion;Immune response;immunosuppressed;Individual;Infection;Infectious Mononucleosis;interdisciplinary approach;interest;International;Kaposi Sarcoma;Laboratories;Lesion;Life;Malignant Neoplasms;Medical;meetings;Membrane Proteins;Meningitis;Mental Retardation;Molecular Biology;Morbidity - disease rate;mortality;Nasopharynx Carcinoma;Neoplasms;opportunistic pathogen;Oral;Oregon;organ transplant recipient;Participant;pathogen;Pathogenesis;Pathogenicity;patient population;Patients;Persons;post-doctoral training;Postdoctoral Fellow;posters;Prevention;Publishing;reactivation from latency;Request for Proposals;Research;Research Personnel;Resistance development;Rest;Science;Scientist;Skin;Structure;Students;symposium;Talents;therapeutic target;Training;Transcriptional Regulation;transmission process;Travel;Ulcer;United States National Institutes of Health;Universities;Vaccination;vaccine development;Viral;Viral Vector;Virus;virus genetics;Work

PROJECT_TITLE: International Herpesvirus Workshop

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-D (M1)]


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE Pediatric frequent asthma exacerbators, defined as those experiencing >1 hospitalization for asthma in a calendar year, are responsible for an outsized proportion of asthma morbidity and mortality. This project aims to characterize the molecular pathways and cell-specific responses dysregulated in this important subgroup. Deeper understanding of these pathways and their potential mediators will uncover new knowledge critical for further mechanistic study and identification of targets for therapeutic intervention.

PI_NAMEs: PHELAN, KIERAN  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Address;Admission activity;Adult;airway epithelium;Allergic;Asthma;asthma exacerbation;asthma model;asthmatic;ATAC-seq;Automobile Driving;Axon;Biological;Blood;Calendar;Cells;Characteristics;Child;Childhood;Childhood Asthma;Chromatin;Clinical;Clinical Data;Collecting Cell;Consent;Coupled;Data;Data Set;density;Development;Disease;Disease Progression;DNA Methylation;eosinophil;Eosinophilia;epidemiologic data;Epigenetic Process;epigenetic regulation;Epithelial Cells;Etiology;Event;Exhibits;experience;Extrinsic asthma;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic Transcription;genomic data;Health Care Costs;Hospitalization;Hospitals;Immunity;Individual;Infection;Inflammation;insight;Intervention;Investigation;Irritants;Knowledge;Laboratories;Literature;Mediating;Mediator;Medical center;Methylation;methylation pattern;Molecular;Morbidity - disease rate;mortality;mouse model;Nasal Epithelium;Nerve;Nervous System;network models;neural;Neurons;neutrophil;novel;Ohio;Pathogenesis;Pathology;Pathway interactions;Patient Admission;Patients;Pattern;Pediatric Hospitals;Peripheral Nervous System;Persons;Pollution;Population;Population Heterogeneity;Population Study;Positioning Attribute;prevent;Process;pulmonary function;Recurrence;repository;repository infrastructure;response;Sampling;Severities;single nucleus RNA-sequencing;single-cell RNA sequencing;Subgroup;Synapses;targeted treatment;Testing;Therapeutic Intervention;Time;transcriptome;transcriptome sequencing;transcriptomics;treatment response;United States;Viral

PROJECT_TITLE: Pathogenesis of frequent asthma exacerbators

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Urologic Diseases

ORG_CITY: HANOVER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Studying development expands our understanding of the cancer phenotype of mature tissues. With a novel imaging platform that exploits development of the newly-identified zebrafish bladder, we will examine developmental changes induced by common environmental chemicals to identify oncogenic mechanisms.

PI_NAMEs: LEACH, STEVEN D (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: activating transcription factor 3;Adult;Affect;Anatomy;automated image analysis;Bioinformatics;bisphenol A;Bladder;Candidate Disease Gene;carcinogenesis;cell type;Chemicals;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;CRISPR gene drive;CRISPR/Cas technology;Databases;design;Detection;Development;differential expression;Environment;Environmental Carcinogens;environmental chemical;Equilibrium;Evaluation;Event;experimental study;Exposure to;Fertility;FGD1 gene;Fishes;Foundations;gain of function;gene cloning;Gene Deletion;Gene Expression;Genes;Genetic;Genetic Transcription;Genitourinary system;Genomics;Goals;Human;imaging platform;improved;Incidence;insight;interest;Intervention;Larva;loss of function;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mammals;manufacture;Modeling;novel;Nuclear Receptors;Oncogenic;overexpression;Pathway Analysis;Phenotype;promoter;Pythons;response;Role;SHH gene;Signal Transduction;single-cell RNA sequencing;smoothened signaling pathway;Surface;System;Testing;The Cancer Genome Atlas;Time;Tissues;tool;Toxicogenomics;Transcription Alteration;transcriptome sequencing;transcriptomics;Transgenic Organisms;tumorigenesis;Urethra;urinary;Urinary system;Urinary tract;urogenital tract;Urothelium;Visualization;Water;Whole Organism;Zebrafish

PROJECT_TITLE: Determination of chemically-induced transcriptomic alterations in bladder oncogenesis using the developing zebrafish urinary system

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cardiovascular;Neurosciences;Physical Activity;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Peripheral Artery Disease (PAD) affects approximately 200 million individuals globally and is projected increase significantly by 2030. The exaggeration of the exercise pressor reflex (EPR) significantly contributes to the mortality and morbidity in PAD. My project will investigate the mechanistic causes of the exaggerated EPR in PAD, offering new opportunities for therapies and reducing the public health burden of PAD.

PI_NAMEs: ORIBAMISE, EUNICE  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Affect;Afferent Neurons;arm;Blood flow;Blood Pressure;blood pressure elevation;Body part;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Chronic;cytokine;Data;Exercise;exercise prescription;Exhibits;experimental study;Feedback;femoral artery;Genes;Genetic Transcription;Heart Rate;high risk;human induced pluripotent stem cells;Hypertension;immune cell infiltrate;Immune response;improved;In Vitro;in vivo;Individual;Induced pluripotent stem cell derived human neuron;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;Innovative Therapy;insight;Intramuscular Injections;Ion Channel;Ischemia;Laboratories;Lead;Ligation;limb movement;Lower Extremity;Macrophage;Measures;Mechanics;Mediating;Mediator;Modeling;Morbidity - disease rate;mortality;Mus;Muscle;Muscle Contraction;Muscle function;muscle repair;neural;Neuroimmune;neuroinflammation;Neurons;novel;novel therapeutic intervention;Pathway interactions;Patients;Peripheral;Peripheral arterial disease;Physiological;Piezo 2 ion channel;Play;pressure;Prevalence;Public Health;Publishing;Quality of life;receptor;Reflex action;Reporting;Research;response;Rodent;Rodent Model;Role;Signal Transduction;Signal Transduction Pathway;single nucleus RNA-sequencing;Skeletal Muscle;somatosensory;Spinal Ganglia;Testing;Up-Regulation;Walking

PROJECT_TITLE: Neuroinflammation as a mediator of the exaggerated Piezo2 and Exercise Pressor Reflex in Peripheral Artery Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-B (20)]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE This proposal develops a microphysiological system to assess the molecular interactions among the cartilage, synovium, and neurons during osteoarthritis (OA). The novel system established here will provide key insight into the complex neuro-immune relationships in OA-associated pain as well as inform the development of potential therapeutics.

PI_NAMEs: MAKARCZYK, MEAGAN JOANNE (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Ablation;Acute;Acute Pain;Affect;Afferent Neurons;Animals;antagonist;Binding;Biological Models;Biomedical Engineering;Blood;Bone Marrow Stem Cell;Calcitonin Gene-Related Peptide;career;Caring;Cartilage;cartilage degradation;Cell Culture Techniques;Cells;chemokine;Chondrocytes;Complex;Conditioned Culture Media;cytokine;Data;Degenerative polyarthritis;design;Development;disability;Disease;drug efficacy;drug testing;effective therapy;Engineering;experimental study;Exposure to;FDA approved;Feedback;Fibroblasts;Future;Human;human tissue;Hypersensitivity;IL8RB gene;Image;Immune;Immune response;In Vitro;Individual;Inflammation;Inflammatory;insight;Interleukin-1 beta;intervertebral disk degeneration;Knee joint;Ligands;Link;Macrophage;Mass Spectrum Analysis;Mediating;Mediator;Medical;Mentors;Messenger RNA;Microelectrodes;microphysiology system;Modeling;Musculoskeletal Diseases;nerve supply;Neurites;Neuroimmune;Neurons;Neuropeptides;Nociception;Nociceptors;novel;osteoarthritis pain;Output;Pain;Pain management;Pathogenesis;Patients;peptide P;Persistent pain;Pharmaceutical Preparations;Play;Prevalence;Production;Proteins;Proteomics;radiological imaging;Rattus;receptor;response;Rodent;Role;Series;Severities;side effect;skills;Specific qualifier value;Substance P;Symptoms;Synovial Membrane;Synovitis;System;Testing;Therapeutic;therapeutic target;Tissues;tool;Training;Work

PROJECT_TITLE: Testing Miniature Knee Joint System as a New Tool to Study Neuroimmune Interactions in Osteoarthritis Pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE In many animals, the propensity to preferentially engage in certain behaviors along day/night cycles is primarily attributed to central circadian clock neurons; however, it remains undetermined whether and how peripheral sensory neurons can contribute to this behavioral rhythmicity. Using Drosophila as a model, this project identifies a neuromodulatory mechanism by which the day or night condition rhythmically regulates peripheral olfactory acuity to external social cues via the antagonistic actions of biogenic amines.The mechanistic insights expected from this research will shed light on the critical roles of peripheral sensory neuromodulation in gating odor-guided behavior by day/night cycles.

PI_NAMEs: SU, CHIH-YING  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Address;Afferent Neurons;Animals;Behavior;Behavioral;Biogenic Amines;Cations;Cell Nucleus;Cells;circadian;circadian pacemaker;communication behavior;Cues;Data Set;Disparity;Drosophila genus;Electrophysiology (science);Exhibits;experimental study;fly;Frequencies;Genes;Genetic;Genetic Epistasis;genetic manipulation;GPCR Signaling Pathway;Impairment;Individual;innovation;insight;knock-down;Light;Mediating;Methods;Modeling;Molecular;Neuromodulator;Neurons;neuroregulation;Octopamine;octopamine receptor;Odorant Receptors;Odors;Olfactory Pathways;Olfactory Receptor Neurons;Pattern;Periodicity;Peripheral;pharmacologic;Pharmacology;Pheromone;Physiological;Physiology;Play;Regulation;Reporting;Research;Resistance;response;Rodent;Role;Sensory;Serotonin;serotonin receptor;Signal Transduction;social;Social Behavior;success;Surveys;Testing;transcriptome sequencing

PROJECT_TITLE: Olfactory neuromodulation: genes, cells, and behavior

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Chronic Pain;Complementary and Integrative Health;Drug Abuse (NIDA only);Endocannabinoid System Research;Natural Products;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: SEATTLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Chronic pain affects nearly 100 million people in the US. Managing pain with opiates has increased the incidence of opioid use disorder and overdose deaths, and therefore effective pain therapeutics with lower abuse potential are needed. This proposal will isolate how Δ9-tetrahydrocannabinol (THC) functions in pain circuits during chronic neuropathic pain and provide new insight into how the endocannabinoid system may regulate and be used to target chronic pain.

PI_NAMEs: ELLIOFF, KAYLIN  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Absence of pain sensation;abuse liability;addiction;Address;Affect;Affective;Agonist;Amygdaloid structure;Analgesics;Anxiety;Attenuated;Basic Science;Behavior;Behavioral;Behavioral Paradigm;Biological;Blood flow;Brain region;Calcium;Cannabinoids;Cannabis;career;Career Choice;career development;Cells;chronic neuropathic pain;chronic pain;chronic pain management;chronic pain relief;Clustered Regularly Interspaced Short Palindromic Repeats;CNR1 gene;Color;Computational Technique;Coupled;CRISPR/Cas technology;Data;Drug usage;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Epilepsy;Fiber;Foundations;G-Protein-Coupled Receptors;Glutamates;Goals;Head;Image;imaging study;in vivo;in vivo calcium imaging;Incidence;Individual;Infusion procedures;innovation;insight;Knock-out;Knowledge;Learning;Legal;Locomotion;Machine Learning;Magnetism;marijuana use;Mediating;Medical Marijuana;Mentors;Mentorship;Modernization;Motivation;Mus;National Institute of Drug Abuse;National Institute of Neurological Disorders and Stroke;negative affect;Nervous System Disorder;neural;Neurobiology;Neurodegenerative Disorders;Neurons;Neuropharmacology;Neurosciences;Nociception;novel;Opioid;opioid use disorder;Output;overdose death;Pain;pain behavior;Pain management;pain perception;pain processing;Pain quality;pain reduction;pain relief;pain signal;painful neuropathy;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Photometry;Physiological;phytocannabinoid;Plants;Play;Population;Prevention;Professional Competence;Property;Publishing;receptor expression;Recreation;recruit;Reporting;Research;Resolution;response;Risk;Role;Scientist;Sensory;Signal Transduction;Site;skill acquisition;Stimulus;Strategic Planning;Stroke;Structure;Substance abuse problem;success;System;Techniques;Technology;Testing;Tetrahydrocannabinol;Therapeutic;Training;treatment response;two-photon;US State;Viral;Work

PROJECT_TITLE: Investigating the role of THC in mediating pain signaling in the BLA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ORG_CITY: BOSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative A Disintegrin and Metalloprotease 10 (ADAM10) is an enzyme that catalyzes the ectodomain shedding of critical signaling and adhesion proteins including Notch, amyloid precursor protein, and cadherins, and its dysregulation is implicated in the development of varied pathologies including neurodegenerative diseases and several cancers. ADAM10 is tightly regulated by the C8 subclass of tetraspanin proteins (TspanC8s) according to mechanisms that are incompletely understood. This proposal aims to combine structural and functional studies of an ADAM10-Tspan5 complex to elucidate mechanisms by which TspanC8s influence ADAM10 substrate selectivity.

PI_NAMEs: PRICE, OWEN M (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Active Sites;Adhesions;Adult;Affect;alpha secretase;Amyloid beta-Protein Precursor;analog;Area;Award;Binding;Binding Proteins;Biochemical;Biochemistry;Biological Assay;Cadherins;Catalytic Domain;Cell Adhesion;Cell Communication;Cell Culture Techniques;Cell Line;Cell surface;Cell Surface Proteins;Cells;Cleaved cell;collaborative environment;Complement;Complex;Cryoelectron Microscopy;Data;Development;Disease;Disease Progression;Disintegrins;Embryonic Development;Engineering;Enzymes;Epidermal Growth Factor Receptor;experience;extracellular;Family member;Functional disorder;Goals;Health;Homeostasis;insight;Integral Membrane Protein;Laboratories;Laboratory Research;Lead;Length;Malignant Neoplasms;medical schools;Membrane;membrane activity;Membrane Proteins;Metalloproteases;Modeling;Molecular;Molecular Conformation;Mutation;Nerve Degeneration;Neurodegenerative Disorders;notch protein;novel therapeutic intervention;Null Lymphocytes;particle;Pathology;Pathway interactions;Pharmacology;Play;Positioning Attribute;preference;Protein Biochemistry;Protein Engineering;Protein Fragment;Proteins;Proteolysis;recruit;Regulation;Research Personnel;Resolution;Roentgen Rays;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Structure;Surface;Tissues;Training;Zinc

PROJECT_TITLE: Structure and Function of an ADAM10-Tspan5 Complex


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Vaccine Related

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative 79% of flu-related deaths between the 2010/11-2019/20 seasons were of people 65 years or older, and although vaccinations are strongly encouraged in this group, elderly vaccine responses are consistently impaired. This study will define the role of CXCL13 as an aging-associated defect in memory T cell homeostasis using CRISPR-engineered tonsil organoids. Results obtained here will improve our understanding of aging immune memory, thus providing the potential for future therapies directed at this axis and limiting the number of deaths to vaccine-preventable diseases.

PI_NAMEs: BEPPLER, CASEY  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Adult;age related changes;Aging;aging related;antigen-specific T cells;Antigens;Apoptosis;Attention;Autoimmunity;B cell differentiation;B-Lymphocytes;Bioinformatics;Biological Assay;BLR1 gene;career;career development;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Maintenance;cell type;Cells;Cessation of life;chemokine;Clustered Regularly Interspaced Short Palindromic Repeats;collaborative environment;Communicable Diseases;Cues;CXCL13 gene;Data;Defect;defined contribution;Disease;Elderly;Engineering;Experimental Models;experimental study;Flow Cytometry;flu;Future;Gene Expression;Genes;Genomics;Goals;Grant;Helper-Inducer T-Lymphocyte;Homeostasis;Human;Human Herpesvirus 4;human model;Immune;Immune response;Immunity;Immunoglobulin G;Immunologic Memory;Immunologic Monitoring;Immunologics;Immunology;Impairment;improved;Individual;Infection;Influenza;Infrastructure;insight;Knock-out;life span;Light;Link;live attenuated influenza vaccine;Lymphoid Tissue;Maintenance;Malignant Neoplasms;Mediating;Mediator;Memory;memory CD4 T lymphocyte;Mentors;Mentorship;Molecular;mouse model;multiple omics;Mus;Myeloid Cells;novel;older adult;Oral;Organoids;overexpression;Peptides;Persons;Phenotype;Play;Population;Predisposition;Production;Productivity;Proliferating;receptor;Research;research and development;Rest;Role;Sampling;seasonal influenza;Seasons;secondary lymphoid organ;single-cell RNA sequencing;skill acquisition;skills;Specificity;Spleen;Stains;Structure of germinal center of lymph node;System;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;Technology;tertiary lymphoid organ;Testing;Tonsil;Training;Transplantation;Vaccination;vaccine response;Vaccines;Work;Writing;young adult

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Machine Learning and Artificial Intelligence;Neurosciences;Pain Research

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative Our proposed work seeks to improve the efficiency and accuracy of endodontic diagnosis even for those who have communication challenges, such as children, using quantifiable physiomarkers of pain. Dental caries is one of the major causes of endodontic infection in the pulp or soft tissues of the tooth and is estimated that at least 2 billion adults and 520 million children suffer from dental caries worldwide. Endodontic infection can cause hypersensitivity, severe pain, and even death, but its diagnosis is currently difficult and dependent on qualitative patient input.

PI_NAMEs: KONG, YOUNGSUN  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: accurate diagnosis;Address;Adult;Affect;Amygdaloid structure;Analgesics;Assessment tool;Bacteria;biological adaptation to stress;Blood Vessels;Cessation of life;Child;Clinical;Communication;Communication difficulty;Comprehension;Cues;Data;Data Set;Dental;Dental caries;Dental Clinics;Dental Pulp;Dentin;Detection;Devices;Diagnosis;effective therapy;effectiveness evaluation;Electric Stimulation;Electrocardiogram;Endodontics;Esthesia;Event;experience;Fingers;Galvanic Skin Response;Gossypium;Human;Hypersensitivity;improved;indexing;Infection;Local anesthesia;Location;machine learning algorithm;machine learning model;Measures;Modeling;Necrosis;Nerve;Nerve Endings;Nerve Fibers;nerve supply;Nervous System Physiology;Odontoblasts;Outcome;Pain;Pain Measurement;pain sensation;Parasympathetic Nervous System;patient response;Patients;periapical;Pulp Canals;pulpal blood flow;Pulpitis;response;Root Tip;Sampling;sensor;Signal Transduction;Skin;soft tissue;Stimulus;Stress;Swab;Sympathetic Nervous System;Testing;Time;Tissues;Tooth structure;Tooth Tissue;Toothache;Training;wearable device;Work

PROJECT_TITLE: Diagnose and Differentiate Dental Pain from Stress Using a Wearable Electrodermal Activity Device

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: Columbus

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE  The proposed studies will fill the knowledge gap in understanding the biomechanical interplay between peripapillary sclera and optic nerve head, a critical factor influencing the eye’s mechanical susceptibility to intraocular pressure. Combined with the development of a translatable technique to image such interplay in vivo, this knowledge will lay the groundwork for developing novel diagnostic and therapeutic strategies to better mitigate glaucoma-related vision loss.

PI_NAMEs: LIU, JUN  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: 3-Dimensional;3D ultrasound;Address;Affect;African American;Aftercare;Age;American;Animal Model;Axon;axon injury;Biochemical;Biomechanics;Blindness;collagenase;combat;Complex;computer studies;Data;Development;diagnostic strategy;elastography;Extracellular Matrix;Eye;Family suidae;feasibility testing;Foundations;genipin;Glaucoma;Human;human old age (65+);Image;imaging modality;Imaging Techniques;in vivo;Individual;Influentials;innovation;Knowledge;Length;Measurement;Measures;Mechanical Stress;Mechanics;modifiable risk;Modification;Modulus;Myopia;nerve damage;neural;novel;novel diagnostics;novel therapeutic intervention;Optic Disk;Optic Nerve;optic nerve disorder;Optical Coherence Tomography;optical imaging;Papillary;Patients;Penetration;Persons;Physiologic Intraocular Pressure;Placebos;Play;porcine model;power analysis;Predisposition;Property;Public Health;Race;Radial;radio frequency;Randomized;Recording of previous events;Resolution;response;retinal imaging;Risk;Risk Factors;Role;Sample Size;Sclera;Stress;submicron;success;Techniques;Testing;Thick;Tissues;treatment effect;treatment group;treatment response;treatment strategy;ultrasound;Vision

PROJECT_TITLE: Biomechanical interplay between optic nerve head and peripapillary sclera


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Los Angeles

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The Emergency Medical Treatment and Labor Act (EMTALA) established a duty for hospitals to screen and stabilize patients presenting to emergency departments with emergent medical or psychiatric conditions regardless of ability to pay. A multidisciplinary team of sponsors, co-sponsors, and key advisors will provide support and guidance as the applicant develops and completes projects to 1) identify and characterize EMTALA citation events involving psychiatric emergencies, 2) explore novel measures of hospital capacity to care for patients with psychiatric emergencies, and 3) evaluate the association between hospital capacity to care for patients with psychiatric emergencies and receipt of EMTALA citations. Through didactics and completion of these projects, the applicant will learn about and gain experience with health policy/analysis, qualitative methods, quantitative methods, impactful dissemination of findings, and grantsmanship, as he trains to become an independent health services researcher.

PI_NAMEs: REICHERT, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: Patient Dumping and EMTALA Enforcement Involving Psychiatric Emergencies

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: DETROIT

ORG_DEPT: CHEMISTRY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative The ability to image hypoxia has vital diagnostic, prognostic, and therapeutic implications. The proposed research is relevant to public health because an innovative approach to mapping hypoxia using magnetic resonance imaging will be made possible through advancing the persistence time of an oxygen-sensitive contrast agent. Consequently, this project is particularly relevant to the NIH’s mission to (1) protect and improve health and (2) ensure the Nation’s capability to prevent disease because the creative chemical approaches described in this project will prove to be a major step in enabling europium-based contrast agents to image hypoxia in a wide range of diseases both preclinically and clinically.

PI_NAMEs: BATCHEV, ANDREA  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Address;Affect;Area;biomaterial compatibility;Carbon Dioxide;Cell Nucleus;Cell Respiration;Characteristics;Chemical Shift Imaging;Chemicals;Clinical;Complex;contrast enhanced;Contrast Media;Creativeness;Diagnostic;Diffusion;Disease;Ensure;Environment;Europium;Excision;experimental study;Exposure to;Fluorine;Fluorocarbons;Gases;Goals;Half-Life;Health;human disease;Hypoxia;Image;Image Enhancement;imaging agent;imaging approach;imaging modality;improved;In Vitro;in vivo;Injections;innovation;interest;Intervention;Ions;Kinetics;Knowledge;Laws;Ligands;Location;Magnetic Resonance Imaging;Maintenance;Maps;Measures;Medicine;Methods;Mission;Modality;nanoemulsion;nanoparticle;Outcome;oxidation;Oxidation-Reduction;Oxygen;Perfusion;photoacoustic imaging;Physiological;Play;pre-clinical;pressure;prevent;prognostic;Property;Proxy;Public Health;ratiometric;Reporting;Research;Resistance;Role;Signal Transduction;Site;Solubility;Spectrum Analysis;Surface;System;Testing;Therapeutic;Time;Tissues;tumor;United States National Institutes of Health;Visualization

PROJECT_TITLE: Outer sphere tuning of a Eu(II)-containing contrast agent for imaging hypoxia via MRI


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Glomerular disease is responsible for a large part of the chronic kidney diseases cases around the world but have very few specific and effective treatments due to poorly understood pathogenic mechanisms. There is a large body of evidence that points to sphingolipid metabolism as a driving force in the progression of glomerular disease. This study aims to define the mechanisms by which alterations in sphingolipid balance and signaling lead to renal injury, thereby allowing us to target these pathways in search of better therapeutic options for patients.

PI_NAMEs: FONTANELLA, ANTONIO MIGUEL (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Affect;Age;Albuminuria;Antisense Oligonucleotides;Apolipoproteins;Apoptosis;Binding;career;Cause of Death;Cell Culture Techniques;Cells;Chronic Kidney Failure;COL4A3 gene;Collagen Type IV;Data;Development;Disease;Disease Progression;driving force;druggable target;effective therapy;End stage renal failure;Equilibrium;Evaluation;experience;Experimental Models;Filtration;Future;Gene Delivery;Genes;Genetic;Goals;Healthcare;Hereditary nephritis;High Density Lipoproteins;Human;improved;in silico;In Vitro;in vivo;in vivo evaluation;inhibitor;Injury;Injury to Kidney;Kidney;kidney cortex;Kidney Diseases;Kidney Failure;kidney fibrosis;knock-down;Knowledge;Lead;lipidomics;Liver;Mediating;Metabolic Pathway;Metabolism;Methods;Microscopy;Modality;Modeling;Molecular;mouse model;Mus;Mutation;novel;overexpression;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Persons;Phenotype;Physicians;Physiological;podocyte;Predisposition;prevent;Proteinuria;Recombinants;Regulation;Renal function;Renal glomerular disease;Reporting;Research;Research Personnel;restoration;Role;Scientist;Signal Transduction;Sphingolipids;sphingosine 1-phosphate;sphingosine-1-phosphate lyase;Steroid-resistant idiopathic nephrotic syndrome;targeted treatment;Testing;Therapeutic;Tissues;Training;United States;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: The Role of Kidney-derived APOM in S1P-mediated glomerular injury

STUDY_SECTION_NAME: Fellowships in Kidney, Urology, and Hematology[DDK-G]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Mental Health;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: FAIRFAX

ORG_NAME: GEORGE MASON UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative This study uses ecological momentary assessment (EMA) to investigate momentary associations between stress and alcohol craving and use in a group of highly stressed mothers of adolescents and whether mindfulness moderates this association. The goal of this study is to identify targets for interventions that may disrupt associations between stress and drinking. Findings from this study will be used to inform interventions, including smartphone-based just-in-time interventions, for alcohol-related problems that may be tailored to meet the needs of women who have been underrepresented in alcohol literature and who have unique social demands and stressors (e.g., parenting).

PI_NAMEs: KISNER, MALLORY  (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: addiction;Adolescence;Adolescent;Adult;Alcohol consumption;alcohol craving;alcohol intervention;alcohol measurement;alcohol related consequences;alcohol related problem;alcohol research;alcohol use initiation;Alcohols;Attention;Award;Buffers;career;Cellular Phone;Child;Child Rearing;Child Welfare;Collection;Communities;craving;Data;Data Analyses;Data Collection;design;Development;drinking;Ecological momentary assessment;Economics;Event;experience;Family;Future;Gender;Goals;Grain;Health;Individual;interest;Intervention;Knowledge;Life;life span;Literature;maternal stress;Mediating;Mentorship;Methodology;Methods;mindfulness;mindfulness intervention;Mothers;multilevel analysis;National Research Service Awards;Parents;Patient Self-Report;perceived stress;Personal Satisfaction;Play;Population;Process;programs;Protocols documentation;recruit;reduced alcohol use;Reporting;Research;research data dissemination;Research Personnel;Research Project Grants;Research Training;response;Role;Sampling;Science;Scientist;social;Social Environment;societal costs;Source;Statistical Methods;Stress;stress reduction;stressor;substance use;Surveys;Testing;theories;Time;Training;United States;Woman;young adult

PROJECT_TITLE: Intensive Longitudinal Associations between Stress, Mindfulness, and Alcohol Use in Highly Stressed Mothers

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Transcriptional control is fundamental to neuronal differentiation, and mutations in machinery critical to this process, such as the Integrator and Z3 complex, give rise to neurodevelopmental defects. Integrator and its associated Z3 complex regulate promoter-proximal RNA Polymerase II, but the molecular underpinnings of this interaction and its importance to brain development are unknown. My work will define the significance of Z3 and INT to neural differentiation using biochemical and functional genomics approaches to shed light on transcriptomic changes crucial for neuron formation.

PI_NAMEs: HASELEY, MARYCLAIRE  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Affect;Auxins;Binding;Biochemical;Biochemistry;Brain;Brain Diseases;career;Cell Differentiation process;Cells;Cerebellar Ataxia;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Coupled;Data;Defect;Development;DNA-Binding Proteins;embryonic stem cell;Exposure to;Fellowship;fitness;functional genomics;Gene Expression;genetic manipulation;Genetic Transcription;Genome;Genomic approach;Genomics;Goals;Human;human embryonic stem cell;human embryonic stem cell line;Immunoprecipitation;Laboratories;Link;Maps;member;Modeling;Molecular;Monitor;Mutation;nerve stem cell;neural;Neurobiology;neurodevelopment;neurogenesis;Neurologic;Neurologic Symptoms;Neuronal Differentiation;Neuronal Dysfunction;Neurons;Neurosciences;Pathogenicity;Patients;Pattern;Phenotype;Point Mutation;Positioning Attribute;premature;Process;promoter;Proteins;Proteomics;recruit;Research Personnel;RNA Polymerase II;Role;Science;Seizures;Syndrome;System;Technical Expertise;Testing;Time;Training;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Untranslated RNA;Western Blotting;Work;Zinc Fingers

PROJECT_TITLE: Characterization of the Integrator-Z3 module as a regulator of neuronal differentiation


NIH_SPENDING_CATS: Chronic Pain;Genetics;Neurosciences;Pain Research;Women's Health Research

PHR: Project Narrative The proposed research is relevant to public health because it identifies sex differences and potential sex- specific therapeutic targets that will impact the clinical care of patients with musculoskeletal pain. This innovative proposal will explore the underlying mechanisms that differentially effect females and males with ischemic muscle pain. This project is aligned with the priority of the NIH Federal Pain Research Strategy to “Elucidate Sex-Specific Pain Mechanisms and Determine their Implications for Optimal Treatment of Pain in Females and Males.”

PI_NAMEs: QUIJAS, MERANDA  (contact)

PROJECT_TERMS: Acute;Affect;Afferent Neurons;antagonist;Area;Behavior;behavior measurement;Behavioral;Behavioral Assay;Biological Assay;Blood flow;Cardiovascular system;Cells;chronic musculoskeletal pain;chronic pain;Clinical;clinical care;Clinical Research;Complex Regional Pain Syndromes;Data;deprivation;Development;disability;Documentation;Electrophysiology (science);Elements;Endocrine system;Exercise;exercise intolerance;Female;Fibromyalgia;Gene Expression Regulation;Genes;Genetic Transcription;Gonadal Steroid Hormones;High Prevalence;Hormones;Hypersensitivity;Immune system;Immunohistochemistry;Inflammatory;inflammatory pain;Injury;innovation;interest;Interleukin-1 Receptors;Ischemia;ischemic injury;Knock-out;Link;Literature;male;Mechanics;median nerve;Messenger RNA;Modeling;Molecular;Molecular Analysis;mRNA Expression;Mus;Muscle;muscle form;Musculoskeletal Pain;Myalgia;Nervous System;Neuroimmune;Neurons;Nociception;Nociceptors;optimal treatments;Oxygen;Pain;Pain management;pain reduction;Pain Research;Pain Threshold;Patient Care;Patients;Peripheral;Peripheral Vascular Diseases;pharmacologic;Phosphorylation;Play;Population;Population Heterogeneity;pre-clinical research;Predisposition;Preparation;Process;Prolactin;Prolactin Receptor;Public Health;receptor;receptor expression;Reflex action;Reperfusion Injury;Reperfusion Therapy;Reporting;Research;response;RNA-Binding Proteins;Role;sex;Sex Differences;Site;Spinal Cord;Spinal Ganglia;STAT protein;STAT3 gene;Stimulus;Structure of ulnar nerve;Testing;therapeutic target;Time;transcriptome sequencing;Transgenic Organisms;treatment strategy;TRPV1 gene;United States National Institutes of Health;Up-Regulation;women versus men;Women's prevalence;World Health Organization

PROJECT_TITLE: Sex dependent effects of prolactin receptor on muscle hypersensitivity following ischemic insult


PHR: Project Narrative This proposal aims to train Jenna Mendelson in molecular and cellular cardiac physiology in order to become an independently funded scientist conducting cardiovascular basic science research to combat cardiovascular disease. Her project investigates the role of mitochondrial fatty acid metabolism in a large animal model of right ventricular dysfunction. During her training, she will develop a new skillset including cardiac MRI, molecular biology techniques, and bioinformatics approaches that will enable her to develop into a productive, independent research scientist conducting translational research, and potentially identify a new therapeutic target for right ventricular dysfunction.

PI_NAMEs: MENDELSON, JENNA BLAIR (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Address;Adenosine Monophosphate;Affect;Anatomy;Animal Model;Animals;antagonist;Basic Science;Bioinformatics;Cardiac;cardiac magnetic resonance imaging;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;Cessation of life;Clinical;clinically relevant;combat;Compensation;Confocal Microscopy;cytokine;Data;Diastolic heart failure;EFRAC;Electron Microscopy;experimental study;Failure;Family;Family suidae;fatty acid metabolism;fatty acid oxidation;Fellowship;FRAP1 gene;Functional disorder;Funding;glycoprotein 130;Goals;Heart;hemodynamics;Human;human disease;IL6 gene;improved;Inflammatory;inhibitor;Interleukin 6 Receptor;Interleukin-6;Left Ventricular Dysfunction;Link;lipidomics;Measurement;Membrane;Metabolic;Metabolic dysfunction;Metabolism;metabolomics;Mission;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Biology;Molecular Biology Techniques;Molecular Profiling;Monocrotaline;Morphology;new therapeutic target;Organelles;Pathway interactions;Patients;pharmacologic;Physiological;Physiology;porcine model;pre-clinical;pressure;Productivity;Protein Kinase;Proteomics;pulmonary arterial hypertension;Pulmonary artery structure;Pulmonary Hypertension;Rattus;Research;Research Project Grants;Right Ventricular Dysfunction;Right ventricular structure;Risk Factors;Rodent;Role;Scientist;Serum;Signal Transduction;skills;small molecule;species difference;STAT3 gene;Structure;Systolic heart failure;Therapeutic;Therapeutically Targetable;Training;Training Support;Translating;Translational Research;ultra high resolution;United States National Institutes of Health

PROJECT_TITLE: Mechanisms of Large Animal RV Dysfunction


NIH_SPENDING_CATS: Assistive Technology;Bioengineering

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: The International Brain-Computer Interface (BCI) Meeting Series is unique in providing an interdisciplinary, collaborative environment that convenes representatives from all fields involved in BCI research, including scientists, engineers, clinicians, policymakers, and users. The 2025 BCI Meeting will highlight innovative approaches and applications for BCIs, discuss progress towards translation, address key issues critical to further progress, and promote the education and participation of young researchers. This meeting and the resulting comprehensive publications will, like its predecessors, foster the translation of BCIs into clinically- viable devices.

PI_NAMEs: COLLINGER, JENNIFER L. (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TITLE: 11th International Brain-Computer Interface Meeting

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Data Science;Emphysema;Lung;Machine Learning and Artificial Intelligence;Pulmonary Fibrosis

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Combined pulmonary fibrosis and emphysema (CPFE) is a life-limiting, progressive lung disease with no rigorously defined standardized diagnostic criteria, which limits multi-center and longitudinal studies. This work begins to fill these critical gaps by establishing quantitative imaging features and thresholds to define CPFE and assessing patient centered outcomes, including survival and lung function decline. By defining CPFE using quantitative imaging, the broader goal of this research is to improve clinical care and early detection for this devastating disease.

PI_NAMEs: WANG, JENNIFER MIN (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Algorithms;American;Award;Biometry;Bronchiectasis;burden of illness;career;career development;Chest;chest computed tomography;Chronic Bronchitis;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Classification;Clinical;clinical care;clinical phenotype;clinically relevant;cohort;Collaborations;comorbidity;Consensus;Critical Care;Cyst;Data;Data Science;Data Scientist;deep learning;design;Development;Development Plans;Diagnosis;Diagnostic;diagnostic criteria;Diagnostic Imaging;Disease;disease phenotype;Early Diagnosis;early screening;Epidemiology;Exclusion;Fellowship;Fibrosis;Foundations;Funding;genetic epidemiology;Goals;Health;Health Care Costs;Health Care Research;Hypoxemia;Image;imaging approach;imaging modality;Imaging Techniques;improved;Individual;instructor;interest;International;Interstitial Lung Diseases;learning classifier;Life;Longitudinal Studies;Lung;Lung Diseases;Machine Learning;Manuscripts;Measures;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Michigan;Mind;mortality;Multicenter Studies;multidisciplinary;Natural Language Processing;Outcome;Outcome Measure;Paper;Patient-Focused Outcomes;Patients;Phenotype;Physicians;Population;Populations at Risk;Prevalence;primary endpoint;Publishing;Pulmonary Emphysema;Pulmonary Fibrosis;pulmonary function decline;Pulmonary Hypertension;quantitative imaging;Radiology Specialty;radiomics;Reporting;Research;Research Personnel;Research Priority;Retrospective cohort;Scanning;Scientist;screening;secondary endpoint;skills;Smoker;Societies;Spirometry;Standardization;Subgroup;symposium;Symptom Burden;Syndrome;Techniques;tool;Traction;Training;Transplantation;Universities;Visual;Work;X-Ray Computed Tomography

PROJECT_TITLE: Defining Combined Pulmonary Fibrosis and Emphysema (CPFE) using Quantitative CT Imaging


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF MEMPHIS

ORG_STATE: TN

PHR: PROJECT NARRATIVE While emerging adults who are not students or graduates of four-year colleges (N4YCEAs) experience greater levels of alcohol misuse and alcohol-related consequences, as compared with four-year college students and graduates, they have relatively limited access to evidence-based brief alcohol interventions (BAIs). In the proposed study we will examine the preferences of N4YCEAs for engaging in BAIs and we will explore the facilitators and barriers to implementing BAIs in the settings they prefer. This mixed methods community- engaged project will lay the foundation for an innovative program of research into the implementation of BAIs in community settings to address this significant public health priority.

PI_NAMEs: TEMPCHIN, JACOB DANIEL (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: Address;Administrator;Age;age group;Alcohol consumption;alcohol measurement;alcohol misuse;alcohol related consequences;alcohol related problem;alcohol use disorder;Alcohols;Area;brief alcohol intervention;brief intervention;Caring;Categories;Clinical Trials;Collaborations;college;Communities;community advisory board;community center;community engaged approach;community engaged research;community setting;Development;Disparity;drinking;Effectiveness;emergency settings;emerging adult;empowerment;Ethnic Population;evidence base;experience;experimental study;Foundations;Future;future implementation;Goals;Health;health care service;health care settings;health disparity;health inequalities;help-seeking behavior;implementation barriers;implementation determinants;implementation efforts;implementation intervention;implementation research;implementation science;implementation strategy;improved;innovation;Institute of Medicine (U.S.);Intervention;Intervention Studies;Interview;Investigation;Learning;life span;Life Style;Literature;member;Mental Health;Mentors;Methods;Modality;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;Outcome;peer;Persons;Pharmaceutical Preparations;Population;Poverty;preference;Primary Care;primary care provider;programs;Provider;psychiatric comorbidity;Public Health;public health priorities;racial minority population;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Sampling;Services;Site;sleep health;Strategic Planning;Stress;Structure;substance use treatment;Surveys;Underserved Population;United States;university student;Work

PROJECT_TITLE: Reaching Non-Four-Year College Emerging Adults with Brief Alcohol Interventions: An Investigation of Service User Preferences and Implementation Determinants


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Digestive Diseases;Food Allergies;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition;Obesity;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Cardiovascular disease remains the leading cause of death in the United States and worldwide. Using the Multi-Ethnic Study of Atherosclerosis, this project evaluates the novel hypothesis that the presence of food specific IgE (sensitization), a prevalent condition, is a risk factor for cardiovascular disease, and that consumption of the food allergen modifies this risk. Establishing food sensitization as a risk factor for cardiovascular disease would provide new opportunities for prevention and could have major implications for how food allergy is managed.

PI_NAMEs: KEET, CORINNE  (contact);WILSON, JEFFREY M

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Address;Adult;Affect;Affinity;Allergens;Allergic;Angiography;anti-IgE;Antibodies;Arterial Fatty Streak;Atherosclerosis;Binding;Biological Assay;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular disorder therapy;cardiovascular risk factor;Cattle;Cause of Death;Cells;Cessation of life;Cicatrix;Circulation;Clinical;clinical practice;cohort;Consumption;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary computed tomography angiography;coronary fibrosis;Data;design;Development;dietary;disease phenotype;disorder subtype;Eating;Effector Cell;egg;epidemiology study;Event;Fishes;follow-up;Food;food allergen;food consumption;Food Hypersensitivity;Goals;Guidelines;Health;Heart;High Prevalence;high risk;Homeostasis;Hypersensitivity;Hypertension;IgE;IgE Receptors;IgG4;Image;Immune;Individual;Inflammation;Inflammation Mediators;Inflammatory;Interleukin-6;Macrophage;Macrophage Activation;mast cell;Measures;Meat;Mediating;Milk;modifiable risk;mortality;mouse model;Multi-Ethnic Study of Atherosclerosis;novel;Nutritional;oral immunotherapy;Pathway interactions;Phenotype;Predisposing Factor;Prevention;Psoriasis;Publishing;Questionnaires;Reporting;Research;Resolution;Risk;Risk Factors;Role;Shrimp;soy;Surveys;Symptoms;theories;Tissues;United States;Validation;Virginia;Wheat;wound healing;X-Ray Computed Tomography

PROJECT_TITLE: The Role of Food Sensitization in Cardiovascular Disease

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STRUCTURAL BIOLOGY CENTER

PHR: PROJECT NARRATIVE As seen with the COVID-19 pandemic and aftermath, RNA viruses continue to be a threat to public health and demand evolution in vaccines and therapeutics. Ironically, some RNA viruses contain molecular tools that can be co-opted to combat emerging viruses. This project is focused on identifying novel architectural strategies used by RNA viruses that can be integrated in therapeutic vaccination systems to combat viruses.

PI_NAMEs: SEGAR, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Affinity;Amphibia;Architecture;Binding;Biochemical;Biochemistry;Bioinformatics;Biotechnology;Birds;Cell Culture Techniques;Cells;Characteristics;Chemicals;circular RNA;Classification;combat;Complex;Computing Methodologies;COVID-19 pandemic;Cryoelectron Microscopy;Data;Databases;Elements;emerging virus;Eukaryotic Initiation Factor-3;Eukaryotic Initiation Factors;Evolution;Fishes;Genome;Health;Hepatitis C virus;Heterogeneity;Infection;insight;intermolecular interaction;Internal Ribosome Entry Site;Link;Mammals;Mass Spectrum Analysis;Messenger RNA;Methods;Molecular;novel;particle;Process;Proliferating;Public Health;recruit;Repression;Research;Ribosomes;RNA;RNA Viruses;Scanning;Sequence Homology;Statistical Data Interpretation;stem;structural biology;Structure;Structure-Activity Relationship;Subgroup;System;Tail;Testing;Therapeutic;therapeutic RNA;tool;translation assay;Translation Initiation;Translational Repression;Translations;Vaccine Therapy;Vaccines;Variant;Viral Genome;viral RNA;Virus;Virus Diseases;Visualization;Western Blotting;Work

PROJECT_TITLE: Functional implications of structural heterogeneity in a viral RNA translation initiation element


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE Engineered cell therapies have successfully treated many blood cancers but have experienced challenges treating solid tumors due to issues involving specificity of the cells for the tumor and how the tumor suppresses these therapeutic cells. This project aims to address these challenges to improve the safety and potency of solid tumor cell therapy by engineering cells with a synthetic genetic circuit that allows them to sense modestly hypoxic tumors and express molecules to kill tumor cells and mitigate immunosuppression. If successful, this project will provide a new therapeutic technology that enables the development of safer, more effective cell therapies for solid tumors.

PI_NAMEs: SCHREIBER, YANNICK RENE (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acceleration;Address;Animal Model;Animals;anticancer activity;Antigen Presentation;Antigens;Antitumor Response;Automobile Driving;Autopsy;barrier to care;Benchmarking;Biodistribution;Biological Assay;Biological Markers;Biosensor;Cancer Model;CAR T cell therapy;CD44 gene;Cell Survival;Cell Therapy;Cells;Characteristics;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;cytokine;cytotoxicity;Data;design;Development;Disease;Disseminated Malignant Neoplasm;Dose Limiting;Drug or chemical Tissue Distribution;Effectiveness;engineered T cells;Engineering;Evaluation;experience;Feedback;female reproductive system;Genes;Genetic;Genetic Transcription;Genome;Goals;Head and Neck Neoplasms;Hematologic Neoplasms;Hematopoietic Neoplasms;Histologic;Human;Hypoxia;Immunosuppression;improved;In Vitro;in vivo;Incubated;Infiltration;Injections;innovation;Interleukin-12;Interleukin-15;Interleukin-2;Intravenous infusion procedures;laboratory experience;lentiviral-mediated;Lentivirus Vector;Liver;Lung;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Modeling;Mus;Natural Killer Cells;neoplastic cell;Normal tissue morphology;normoxia;novel;novel therapeutics;Output;Pathway interactions;Performance;Reagent;receptor expression;Research;response;Risk;Safety;Signal Transduction;SKOV3 cells;Solid Neoplasm;Specificity;success;synthetic biology;Synthetic Genes;systemic inflammatory response;T-Cell Activation;T-Lymphocyte;Technology;Therapeutic;Tissues;Toxic effect;transgene expression;Translating;tumor;Tumor Antigens;tumor growth;tumor hypoxia;tumor microenvironment;tumor-immune system interactions;Work;Xenograft procedure

PROJECT_TITLE: Development of Tunable Microenvironment-Responsive CAR T Cells Using Synthetic Gene Circuits to Enhance Potency and Safety

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (22)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Glaucoma degrades vision and quality of life in hundreds of thousands of veterans. To date, vision loss resulting from the disease is irreversible. Lowering intraocular pressure (IOP) has been proven beneficial for most patients, but low patient compliance with daily eye drop regimens hampers the treatment success. We have previously demonstrated that transplantation of induced pluripotent stem cell derived material into the anterior chamber of the eye can reestablish the eye's natural ability to control IOP. The goal of this project is to test more efficient transplantation strategies, evaluate whether allotransplantation Is effective and safe and, crucially, to demonstrate that rehabilitation of IOP control is possible in human eyes with primary open angle glaucoma. This highly innovative treatment approach could provide physicians with a new therapeutic option and improve quality of life in veterans with glaucoma.

PI_NAMEs: KUEHN, MARKUS H. (contact)

PROJECT_TERMS: age related decline;allotransplant;anterior chamber;Aqueous Humor;Biology;Biomechanics;Biomedical Engineering;Blindness;Caring;Cell Density;Cell Therapy;Cell Transplantation;cell type;Cells;Cellular Morphology;Cellularity;Cities;Clinic Visits;Clinical;clinical diagnosis;clinical practice;Clinical Services;Clinical Trials;cost;Data;design;Development;Diagnosis;Disease;Doctor of Philosophy;effective therapy;effectiveness evaluation;expectation;experience;Eye;Eye Banks;eye chamber;Eye diseases;Eyedrops;Failure;Functional impairment;functional restoration;Future;Glaucoma;Goals;Healthcare Systems;high intraocular pressure;Human;implantation;improved;induced pluripotent stem cell;innovation;Iowa;Laboratories;Magnetism;Medical;Medical center;mouse model;Mus;Natural regeneration;novel;novel strategies;novel therapeutics;Organ Culture Techniques;Pathologic;Patient Compliance;Patients;Perfusion;Physicians;Physiologic Intraocular Pressure;preservation;prevent;Prevention;Primary Open Angle Glaucoma;professor;Proliferating;Quality of life;Regenerative capacity;regenerative treatment;Regimen;Rehabilitation therapy;repaired;Research;Resources;restoration;Risk Factors;Safety;stem cell delivery;success;Techniques;Technology;Testing;Tissues;Trabecular meshwork structure;translational study;Translations;Transplantation;treatment strategy;United States Department of Veterans Affairs;Veterans;Vision;Visual

PROJECT_TITLE: Translational Studies toward Cell Therapy for Treatment of Primary Open Angle Glaucoma

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE Vascular dysfunction is one of the earliest pathological signs in the progression of Alzheimer’s disease, and cerebral ischemic injuries increase a patient’s risk of developing dementia. Endothelin-1 is increased in patients with AD and ischemia, likely leading to excess vasoconstriction and dysfunction of neurovascular coupling. This proposal will investigate whether endothelin-1 causes neurovascular coupling dysfunction after an ischemic injury and whether this contributes to Alzheimer’s disease-associated dementia.

PI_NAMEs: WOODRUFF, SIMONE  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Abate;abeta deposition;Acute;Adult;Affect;Aftercare;Age;Aging;Agreement;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Amyloid beta-Protein;Anxiety;Attenuated;awake;Behavioral;Behavioral Assay;behavioral impairment;Blood flow;Blood Vessels;blood-brain barrier permeabilization;Brain region;Cerebral Hypoxia;cerebral ischemic injury;cerebrovascular;Cerebrovascular Circulation;Chronic;cognitive function;cohort;constriction;Data;Dementia;Deposition;Development;Disease Marker;Disease Progression;emerging adult;Endothelin Receptor;Endothelin-1;Event;Exposure to;field study;Functional disorder;Future;Generations;Genotype;Gliosis;Glucose;Goals;Head;Histopathology;Hypoxia;Immunohistochemistry;Impaired cognition;Impairment;Implant;in vivo;Individual;Infarction;inhibitor;innovation;insight;Ischemia;ischemic injury;Ischemic Stroke;Laser Speckle Imaging;Life;Link;Locomotion;Long-Term Effects;Measures;Mediating;memory recognition;Metabolic;middle age;mixed dementia;mouse model;Mus;neural;Neurodegenerative Disorders;Neuroglia;Neurologic Dysfunctions;neuron loss;Neurons;neurovascular coupling;Nitric Oxide;novel;novel therapeutics;object recognition;osmotic minipump;Outcome;overexpression;Oxidative Stress;Oxygen;Pathologic;Pathology;Patient risk;Patients;Peptide Initiation Factors;Pilot Projects;post stroke;prevent;Process;Production;Reactive Oxygen Species;Recording of previous events;response;Rodent;Role;Series;sham surgery;Short-Term Memory;Signal Pathway;Signal Transduction;Stroke;subcortical ischemic vascular disease;Testing;Tg2576;therapeutic target;vascular abnormality;Vascular Diseases;vasoconstriction;Vasoconstrictor Agents;Wild Type Mouse

PROJECT_TITLE: Contribution of endothelin 1 mediated ischemic vascular dysfunction to Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Sarcomas driven by gene fusions between Capicua (CIC) and several partner genes including DUX4 and NUTM1 present as aggressive tumors with dismal outcomes and few treatment options. This project will improve our understanding of the biology underlying these diseases by dissecting how CIC-DUX4 can be relocalized within a cell, and by uncovering the mechanisms CIC-NUTM1 uses to drive tumors. This knowledge will reveal new ways to inactivate the driving causes of CIC-rearranged sarcomas, leading to more effective therapies for an underserved patient population.

PI_NAMEs: LUCK, CUYLER  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Agar;Area;Automobile Driving;Binding;Biology;cancer type;career;Cell Line;Cell model;Cell Nucleus;Cells;Central Nervous System;Characteristics;Chemicals;Chimeric Proteins;Clinical;Cytoplasm;Data;Development;Disease;DNA;effective therapy;Engineering;Environment;EP300 gene;experimental study;Failure;Family;Fellowship;Fibroblast Growth Factor;Foundations;Fusion Oncogene Proteins;Future;gene function;Gene Fusion;gene induction;Genes;Genetic;Immunofluorescence Immunologic;Immunoprecipitation;Impairment;improved;in vivo Model;Individual;Knowledge;live cell imaging;Measures;Mediating;Mentorship;Microscopic;Microscopy;Modeling;mouse model;Mus;neoplastic cell;novel;novel therapeutic intervention;Oncoproteins;Outcome;overexpression;patient population;Patients;Plasmids;posttranscriptional;Prognosis;Property;protein structure;Proteins;Publishing;Receptor Protein-Tyrosine Kinases;recruit;Reporting;Research;Research Personnel;Role;Sarcoma;Shapes;Signal Pathway;Signal Transduction;Small Interfering RNA;Soft Tissue Neoplasms;Specificity;Spinal Cord;SRC gene;stable cell line;Structure;Techniques;Testing;Training;Transactivation;transcription factor;Transcription Repressor;translational cancer research;treatment and outcome;treatment strategy;tumor;Tumor Suppressor Proteins;tumorigenesis;Tyrosine;Visualization;Western Blotting;Work;Writing

PROJECT_TITLE: Leveraging Retained Partner Gene Function to Effectively Target CIC-rearranged Fusion Oncoproteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE In stroke rehabilitation, it is believed that improving an individual’s capacity (what they are capable of doing on in-clinic measures) leads to improvements in an individual’s performance (what they actually do in the real- world); however, recent work has identified that an individual’s capacity and performance are not always congruent after rehabilitation. Learned non-use, the incongruence between capacity and performance after stroke, was originally identified in deafferented animal models with impaired proprioception, and this proposal will focus on the critical gap related to the contributions of proprioception on learned non-use in individuals with stroke. Completion of this proposed research will identify potential underlying mechanisms of learned non-use that will inform future rehabilitation efforts to combat this phenomenon that limits full functional recovery. .

PI_NAMEs: HOH, JOANNA ESKANDER (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Accounting;Affect;Animal Model;Animals;arm;arm movement;arm paresis;Behavioral;Bilateral;body position;body sense;Classification;Clinic;Clinical;combat;constraint induced movement therapy;cost;Deafferentation procedure;Development;disability;disability burden;Equipment and supply inventories;Exhibits;Feedback;Future;Goals;Hand;Health;Impairment;improved;improved outcome;Incentives;Individual;instrument;international health organization;Intervention;Knowledge;Laboratories;Learning;Life;Limb structure;Link;Literature;Measures;Modeling;Monitor;Motor;motor deficit;motor rehabilitation;Movement;neglect;Outcome;Outpatients;Participant;Patient Self-Report;Performance;Persons;post stroke;Proprioception;Quality of life;Recovery;Recovery of Function;rehabilitation research;rehabilitation service;Rehabilitation therapy;Reporting;Research;Robotics;Self Care;Sensory;sensory system;Stroke;stroke rehabilitation;System;Technology;Time;timeline;United States;Upper Extremity;Work;World Health Organization

PROJECT_TITLE: Understanding the Contributions of Proprioceptive Impairment on Arm Capacity and Real-World Performance After Stroke


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Abnormal posture and postural instability are treatment-resistant symptoms of Parkinson’s disease (PD) that contribute significantly to decreased mobility, falls, and reduced quality of life, and the mechanisms contributing to these motor signs are poorly understood. This project will use two noninvasive neuromodulation techniques (transcranial magnetic stimulation and electrical vestibular stimulation) to explore the characteristics of the neural control of the trunk muscles in sitting, standing, and turning in people with PD compared to healthy controls. The results of these experiments will increase our knowledge of the impact of PD on the neural control of the trunk in abnormal postures which will help with the development of targeted therapies to improve postural instability in people with PD.

PI_NAMEs: MAUPIN, CALLEN M (contact)

PROJECT_TERMS: Address;Adult;Attenuated;Biomechanics;career;Characteristics;Chest;Clinical;comparison control;Contralateral;Coupled;Coupling;Data;Deep Brain Stimulation;Development;Diagnosis;Disease;dopamine replacement therapy;Electromyographs;Electrophysiology (science);Environment;Equilibrium;experimental study;falls;Fellowship;Functional disorder;Gait;Head;Impairment;improved;indexing;insight;Ipsilateral;kinematics;Kinetics;Knowledge;Laboratories;Lateral;Leg;Length;Levodopa;Measures;Methods;Minnesota;Mobility decline;Morbidity - disease rate;Motor;Motor Cortex;Motor Evoked Potentials;motor symptom;Movement;Movement Disorders;multidisciplinary;Muscle;Musculoskeletal Equilibrium;Neural Pathways;Neurodegenerative Disorders;neuromechanism;neurophysiology;neuroregulation;novel;Pain;Parkinson Disease;Pathogenesis;Pathway interactions;Pelvis;Persons;Phase;Physiologic pulse;Postural adjustments;Posture;posture instability;programs;Property;Quality of life;Reaction;rehabilitation science;Rehabilitation therapy;Research;Research Infrastructure;Resistance;response;Role;Rotation;Scientist;Side;skill acquisition;Surface;symptom treatment;Symptoms;System;targeted treatment;Techniques;Testing;Training;Transcranial magnetic stimulation;trend;Universities;Vertebral column;vestibular system;Walking;Work

PROJECT_TITLE: Neural mechanisms of impaired postural control in people with Parkinson's disease


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Immune checkpoint inhibitor therapy, such as PD-1 blockade therapy, has substantially improved the treatment of triple negative breast cancer but limitations persist. Investigating understudied components in the tumor microenvironment, such as B lymphocytes, could improve clinical outcomes and inform future therapeutic studies. Our preliminary data suggest that PD-blockade therapy could regulate the antitumor function of B lymphocytes, and additional investigation is needed to better understand this mechanism.

PI_NAMEs: PAN, XIAOLU  (contact)

PROJECT_TERMS: Address;Animals;anti-PD-L1 therapy;anti-PD1 antibodies;Antibodies;Antibody Formation;antigen detection;Antigen Presentation;Antigens;Antitumor Response;Attention;B cell differentiation;B Cell Proliferation;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Neoplasm;B-Lymphocyte Subsets;B-Lymphocytes;Breast Cancer Model;Cancer Patient;cancer therapy;cancer type;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Cell Differentiation process;Cell Physiology;Cell Survival;Cells;Cellular Metabolic Process;checkpoint therapy;Chromatin;Clinical;clinical care;Coculture Techniques;Collaborations;Coupled;Cytotoxic Chemotherapy;Data;Dependence;Development;druggable target;Environment;ERBB2 gene;Estrogen receptor negative;Evaluation;Fatty Acids;Flow Cytometry;Future;Gene Expression Regulation;Gene Modified;Generations;Glycolysis;Goals;immune cell infiltrate;Immune checkpoint inhibitor;Immune Targeting;immunogenic;Immunoglobulin-Secreting Cells;Impairment;improved;in vivo;Infiltration;interleukin-21;Investigation;Location;Malignant Breast Neoplasm;Maps;Melanoma;Mentors;Metabolic;Metabolic Pathway;Metabolism;Metastatic Melanoma;Methods;mouse model;Mus;novel therapeutic intervention;Oranges;Outcome;Pathway interactions;Patients;Play;Pre-Clinical Model;Production;progesterone receptor negative;Prognosis;programmed cell death protein 1;programs;Proliferating;Proteins;Reagent;Receptor Activation;Regulation;Reporter;Research;response;restraint;Role;Shapes;Signal Pathway;Signal Transduction;standard of care;Structure of germinal center of lymph node;success;System;T-Lymphocyte;targeted treatment;tertiary lymphoid organ;Therapeutic Studies;tool;transcription factor;transcriptome;transcriptomics;Transgenic Organisms;Treatment Efficacy;Treatment outcome;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Function of PD-1 Signaling on the Activity of B cells in the Tumor Microenvironment in Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE Inflammation plays a major role in heart and vascular disease and is driven in large part by immune cells, which can dynamically increase or resolve inflammation; however, most knowledge related to specific roles of immune cells in heart and vascular disease is from animal models, which have immune systems that differ from humans in important ways. We address this gap directly in this application, in which we will determine precise immune cell features in the blood and arterial plaque of humans underlying heart attack, stroke, and leg artery disease. This offers the potential to uncover precise, human-relevant immune cell components that may be targeted to resolve inflammation and reduce human heart and arterial disease risk.

PI_NAMEs: FEINSTEIN, MATTHEW JOEL (contact);THORP, EDWARD BENJAMIN

PROGRAM_OFFICER_NAME: POOL, LINDSAY REGINA

PROJECT_TERMS: Acute;Address;Adult;Affect;Ancillary Study;Animal Model;Arteries;Atherosclerosis;Biological Assay;Blood;Blood specimen;cardiovascular disorder risk;Carotid Artery Plaques;Carotid Stenosis;case control;Cell Physiology;Cell Separation;Cell Survival;Cells;Cellular Metabolic Process;Cellular Structures;Cessation of life;Chromatin;claudication;Clinical;Clinical Trials;cohort;comparative;Coronary;cost;Data;design;Disease;Disease Progression;disorder risk;Endarterectomy;Energy Metabolism;Epidemiology;epidemiology study;Epigenetic Process;epigenetic regulation;Equilibrium;Event;Experimental Models;FCGR3B gene;Femur;follow-up;Freedom;Freezing;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Heart Diseases;Heterogeneity;high risk;Histology;Human;human data;Immune;Immune system;Immune Targeting;Immunologics;imprint;indexing;Infection;Inflammation;Inflammatory;Inflammatory Response;insight;Ischemic Stroke;Knowledge;Leg;limb ischemia;Link;Lipids;Lower Extremity;Macrophage;Macrophage Activation;Measures;Metabolic;metabolic profile;Metabolism;monocyte;Morphology;Multi-Ethnic Study of Atherosclerosis;Mus;Myocardial Infarction;Onset of illness;optimal treatments;Oxidative Phosphorylation;Participant;Patients;Peripheral arterial disease;Peripheral Blood Mononuclear Cell;Persons;pharmacologic;Phenotype;Play;polarized cell;population based;preference;preservation;prevent;prospective;Recurrence;Regulatory Element;Residual state;Resolution;Risk;RNA;Role;Sampling;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Site;Specimen;Stroke;Surface;systemic inflammatory response;Therapeutic;Time;Tissues;transcriptome;transcriptomics;vascular bed;Vascular Diseases

PROJECT_TITLE: Integrated epidemiology of systemic and plaque-specific immunologic features of human atherosclerosis


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Lung;Neonatal Respiratory Distress;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

ORG_STATE: MO

PHR: Dexamethasone and other synthetic glucocorticoids are commonly used to prevent bronchopulmonary dysplasia in preterm infants but they are known to impair brain and somatic growth. Ciclesonide is a synthetic glucocorticoid prodrug that is rapidly converted to its active form in the lung and has been shown in neonatal models of brain and lung injury to be as efficacious in preventing lung injury without causing significant brain or systemic toxicity. In this study, we will pursue a phase I dose escalation clinical study using an inhaled preparation of ciclesonide to establish its safety and toxicity profile in preterm infants, while also assessing levels of CIC metabolites and glucocorticoid receptor activation profile.

PI_NAMEs: SAMPATH, VENKATESH  (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: 2 year old;absorption;Academy;Acute;Address;Adrenal Glands;Adverse effects;Affinity;Allergic rhinitis;American;Architecture;Asthma;Binding;Binding Proteins;Biological Availability;Blood Pressure;Blood specimen;Bone Growth;Brain;brain dysfunction;Brain Injuries;Bronchopulmonary Dysplasia;carboxylesterase;Cause of Death;Cerebral cortex;Cerebral Palsy;Characteristics;Child;Chronic;Chronic lung disease;Clinical Research;Clinical Trials;Data;Dexamethasone;Distal;Dose;Drug Kinetics;endotracheal;Evaluation;Experimental Models;extreme prematurity;FDA approved;Fright;Gene Expression;Genes;Genetic Transcription;Glucocorticoid Receptor;Glucocorticoids;Goals;Growth;Guidelines;Hydrocortisone;Hyperglycemia;Hyperoxia;Hypertension;Impairment;individualized medicine;Infant;Infection;Inhalation;Insulin-Like Growth Factor I;Intestinal Perforation;Life;Liquid Chromatography;liquid chromatography mass spectrometry;Liver;long bone;Lung;Lung Diseases;lung injury;Mass Spectrum Analysis;Measures;Mechanical ventilation;Mediating;Meta-Analysis;metabolic abnormality assessment;Metabolism;Modeling;mortality;Neonatal;Neonatal lung;Neuroanatomy;neurodevelopment;Neurologic;neurosensory;Newborn Infant;novel therapeutics;open label;Parents;Pathology;Pediatrics;Pharmaceutical Preparations;Phase;phase 1 study;Population;postnatal;preclinical study;Pregnancy;Premature Infant;Preparation;prevent;Process;Prodrugs;Prosencephalon;protective effect;Pulmonary Valve Insufficiency;Quantitative Reverse Transcriptase PCR;Randomized, Controlled Trials;Rattus;Receptor Activation;Recommendation;Regimen;Reporting;Research Design;Resolution;response;Risk;RNA;Rodent;Rodent Model;Safety;Serious Adverse Event;Serum;side effect;success;Survivors;Symptoms;systemic toxicity;Testing;Therapeutic Glucocorticoid;Therapeutic Uses;Toxic effect;transcriptome;Tube;Whole Blood

PROJECT_TITLE: Inhaled ciclesonide - a phase I study in preterm infants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: RELEVANCE NSUN2 is an RNA methyltransferase that converts cytosine to 5-methylcytosine (m5C) and is required for the decoding activity and stability of tRNAs and coding/noncoding mRNAs. NSUN2 mutations have been widely involved in developmental defects, including male infertility, Dubowitz-like syndrome, and intellectual disability, as well as in cancer. Dissecting the unique functions of the NSUN2-regulated epitranscriptome through liquid- liquid phase separation in the translational control of pluripotent stem cells is fundamental to developmental biology and disease modeling.

PI_NAMEs: WANG, JIANLONG  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;adult stem cell;angiogenin;attenuation;Binding;Biological Models;cancer stem cell;Cell Cycle;Cell Differentiation process;Cells;Cleaved cell;Code;Complex;Cytosine;Data;data integration;Defect;Dependence;Development;Developmental Biology;developmental disease;Disease;disease model;embryonic stem cell;endonuclease;epitranscriptome;Foundations;Homeostasis;insight;Intellectual functioning disability;Knock-out;Knowledge;Length;Link;Liquid substance;Male Infertility;Malignant Neoplasms;Mediating;Membrane;messenger ribonucleoprotein;Messenger RNA;Methylation;methylome;Methyltransferase;Modeling;Modification;mRNA Translation;Multiomic Data;Mus;mutant;Mutation;novel;Organelles;particle;Phase;pluripotency;Pluripotent Stem Cells;Post-Transcriptional Regulation;Post-Transcriptional RNA Processing;Process;Property;Protein Biosynthesis;protein expression;Proteins;Reader;Reporting;Repression;RNA;RNA methylation;RNA-Binding Proteins;self-renewal;Shapes;Somatic Cell;stem cell fate;Stem cell pluripotency;stress granule;Syndrome;System;Testing;transcriptome;Transfer RNA;Translation Initiation;Translational Regulation;Translational Repression;Translations;translatome;tumorigenesis;Undifferentiated;Untranslated RNA;Up-Regulation;Work

PROJECT_TITLE: Decoding NSUN2-mediated translational control of pluripotent stem cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-M (02)]