NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Endocrine Disruptors;Estrogen;Genetics;Human Genome;Liver Disease;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Early life exposures to endocrine disrupting chemicals, such as bisphenols and phthalates, can increase the lifetime risk of developing non-alcoholic fatty liver disease (NAFLD) – a disease that is being increasingly diagnosed in children. Bisphenols and phthalates have been shown to trigger release of Damage Associated Molecular Pattern (DAMP) proteins that promote oxidative, inflammatory, and metabolic stress through activation of receptor for advanced glycation end products (RAGE) signaling and epigenomic reprogramming. Our proposed studies will test the hypothesis that exposure to a bisphenol/phthalate mixture activates DAMP/RAGE signaling, alters the epigenomic/transcriptomic landscape in liver and peripheral monocytes, and promotes metabolic dysfunction upon later life challenge (e.g., Western diet).

PI_NAMEs: SCHMIDT, ANN MARIE;TRASANDE, LEONARDO ;TREVINO, LINDSEY STARR (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Adolescence;Adolescent;Adult;Adverse effects;Age;Bioinformatics;Biological;Biological Markers;Biology;Biometry;bisphenol A;Bone Marrow;Cell Death;Cells;Child;Child Health;cohort;Collaborations;Data;Development;Diagnosis;Diethylhexyl Phthalate;Disease;Disease Progression;early childhood;early life exposure;Endocrine Disruptors;Environment;Epigenetic Process;epigenome;epigenomics;Exposure to;Fatty Liver;fetal;Human;human subject;Human Subject Research;Immune;Immune response;Immunity;in utero;in vivo;Inflammatory;Lactation;late life;Life;lifetime risk;Ligands;Link;lipidomics;Liver;Liver diseases;liver injury;Macrophage;Mediating;Metabolic;Metabolic dysfunction;Metabolic stress;Metabolic syndrome;Metabolism;Molecular;monocyte;mouse model;Mus;Myelogenous;neonatal mice;New York City;non-alcoholic fatty liver disease;novel;Obesity;obesity in children;offspring;Organ;Pathway interactions;Patients;Pattern;Perinatal Exposure;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;phthalates;pregnant;Pregnant Women;Prevalence;Production;programs;Proteins;Public Health;receptor;Receptor Activation;receptor for advanced glycation endproducts;recruit;Research Personnel;response;Risk Factors;Role;safety testing;Serum;Signal Pathway;Signal Transduction;Stimulus;Stress;Testing;Therapeutic;Training;transcriptome;transcriptomics;western diet;Zebrafish

PROJECT_TITLE: Early Life Exposure to Endocrine Disrupting Chemicals: Epigenomic and Transcriptomic Networks and RAGE in Liver Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 VSM-S (VC)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Genetic variants in TREM2, an immune receptor on microglial cells, are associated with a spectrum of neurodegenerative conditions, including Alzheimer’s disease. We found that some of pathogenic variants in this gene affect RNA splicing. We will identify genetic variation causing TREM2 mis-splicing and elucidate its role in AD predisposition.

PI_NAMEs: KORVATSKA, OLENA  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3' Untranslated Regions;Address;Affect;African;African American population;Age;age related;Alleles;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;apolipoprotein E-4;autosomal dominant trait;Binding;Biological Assay;Brain;Brain region;Code;Codon Nucleotides;combinatorial;Complex;Consensus;curative treatments;Defect;Dementia;dementia risk;Disease;Disease susceptibility;dosage;early onset;Elderly;Equilibrium;European;Event;exon skipping;experimental analysis;extend lifespan;Frequencies;Frontotemporal Dementia;Functional disorder;Gene Dosage;Gene Expression;Gene Expression Regulation;Gene Proteins;Genes;Genetic Diseases;Genetic Predisposition to Disease;genetic variant;Genetic Variation;Goals;Health;health economics;Health system;Heterozygote;Human;human disease;Immune;Immune signaling;Immunologic Receptors;in silico;Introns;Knowledge;Late Onset Alzheimer Disease;Libraries;Link;loss of function;Loss of Heterozygosity;Macrophage;Maps;Messenger RNA;Microglia;mRNA Precursor;Nerve Degeneration;Neurodegenerative Disorders;non-demented;novel;Nucleotides;Pathogenicity;Pathology;Patients;Persons;Phenotype;Post-Transcriptional Regulation;posttranscriptional;predictive tools;Predisposition;premature;Preventive therapy;Process;protein function;Protein Isoforms;Proteins;Proteomics;receptor;Receptor Signaling;Reporter;Research Design;Resolution;Resources;Risk;Risk Factors;risk variant;RNA Splicing;RNA-Binding Proteins;Role;screening;Sex Differences;Spliced Genes;Spliceosomes;Surface;synthetic biology;Terminator Codon;Tertiary Protein Structure;Testing;Trans-Activators;Transcript;transcriptome sequencing;Translations;transmission process;TREM2 gene;Untranslated RNA;Variant;variant of unknown significance;Work

PROJECT_TITLE: Regulatory variation that affects splicing of the Alzheimer's disease risk gene TREM2

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Digestive Diseases;Inflammatory Bowel Disease;Wound Healing and Care

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: RELEVANCE TO PUBLIC HEALTH Intestinal disorders such as inflammatory bowel disease, celiac disease and infectious colitis represent a serious health problem in the US with their incidence and complications accelerating over the past decades. This project will improve upon the understanding of normal gut physiology and the pathogenesis of gastrointestinal disorders by exploring novel mechanisms that regulate integrity of the gut barrier, development of intestinal inflammation and post-inflammatory mucosal restitution. Furthermore, it will identify a novel target for pharmacological prevention of the intestinal barrier breakdown and accelerated healing of the injured gut mucosa, which would result in decreased morbidity and mortality of a large cohort of patients with inflammatory disorders.

PI_NAMEs: IVANOV, ANDREI IVANOVICH (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Acceleration;Actins;Actomyosin;Acute;Adherens Junction;Apical;Appearance;Attenuated;attenuation;Biochemical;Biopsy;Biosensor;Celiac Disease;Cell Death;Cell Differentiation process;cell motility;Cell Physiology;Cell Separation;Cell-Matrix Junction;Chronic;Chronic Phase;cohort;Colitis;Complex;Confocal Microscopy;CRISPR/Cas technology;Crohn's disease;cytokine;Cytoskeleton;Data;Development;dextran sulfate sodium induced colitis;Digestive System Disorders;Disease;Disease remission;Epithelial Cells;epithelial wound;Epithelium;Filament;Fluorescence Resonance Energy Transfer;gain of function;Gastrointestinal Diseases;Genes;Genetic;gut inflammation;Gut Mucosa;healing;Health;Human;Image;Immune system;Immunoprecipitation;improved;In Vitro;in vivo;Incidence;Infectious colitis;Inflammation;Inflammatory;Inflammatory Bowel Diseases;injured;injury and repair;innovation;insight;intestinal barrier;Intestinal Diseases;intestinal epithelium;Intestinal Mucosa;Intestinal permeability;Intestines;Knockout Mice;loss of function;Measurement;Mechanics;Mediating;Methylation;Methyltransferase;Microfilaments;Microfluidic Microchips;Modeling;Modification;monolayer;monomer;Morbidity - disease rate;mortality;Mucositis;Mucous Membrane;murine colitis;Mutagenesis;Myosin Type II;new therapeutic target;novel;Organoids;overexpression;Pathogenesis;pathogenic bacteria;Patients;Permeability;pharmacologic;Physiology;Post-Translational Protein Processing;prevent;Prevention;Process;Property;Proteins;Public Health;Recovery;Regulation;repaired;restoration;Role;Sodium Dextran Sulfate;Stress Fibers;Structure;Testing;Thick;Tight Junctions;tissue injury;Ulcerative Colitis;Western Blotting;wound;wound healing;Wound models

PROJECT_TITLE: Actin methylation as a novel mechanism that regulates gut barrier integrity and repair

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative During embryonic development of the pulmonary alveolus, a common progenitor pool gives rise to two distinct epithelial cell types in a process requiring both molecular signaling and cell stretch. As both cues exist several days before the epithelial cells are specified, another mechanism is required to time differentiation. We propose a hypothesis ––and our data strongly support–– that timing is controlled by a novel mechanical property named cell membrane tension; if true, this hypothesis will update the model of differentiation of the alveolar epithelium and have fundamental implications for understanding its regulation in lung disease and regeneration, both which we begin to investigate in this proposal.

PI_NAMEs: BROWNFIELD, DOUGLAS GLENN (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Address;Adult;Affect;AGTR2 gene;Alveolar;alveolar epithelium;Alveolus;Bleomycin;Cell Differentiation process;Cell membrane;Cell secretion;Cell Separation;cell type;Cells;Cellular Membrane;Confocal Microscopy;Cues;Data;Development;differentiation in vitro;Disease;Distal;Dyes;Embryo;Embryonic Development;embryonic stem cell;Endocytosis;Endocytosis Inhibition;Endosomes;Epithelial Cells;epithelial repair;epithelial stem cell;Epithelium;epithelium regeneration;experimental study;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Fibroblasts;fluorescence lifetime imaging;Gases;Gene Deletion;Immunofluorescence Immunologic;In Situ;in vivo;indium-bleomycin;Individual;Injury;injury and repair;innovation;laser tweezer;Lung;lung development;Lung Diseases;lung injury;lung regeneration;Mass Spectrum Analysis;Measurement;Measures;mechanical properties;Mechanics;Modeling;Molecular;mouse model;Mus;Names;Natural regeneration;novel;novel diagnostics;novel strategies;novel therapeutic intervention;novel therapeutics;optic tweezer;Patients;Play;Pregnancy;Process;progenitor;programs;Proteomics;Pulmonary alveolar structure;Pulmonary Surfactants;receptor;regenerative;Regulation;repaired;Repression;Resolution;Role;Signal Pathway;Signal Transduction;small molecule;Specific qualifier value;stem cell differentiation;Stretching;Structure of parenchyma of lung;Surface;Testing;Thinness;Time;tool;Transgenic Mice;Update;uptake;Viral;Viral Vector;Western Blotting;Work

PROJECT_TITLE: INTEGRATION OF MECHANICAL AND MOLECULAR CUES DURING DISTAL LUNG DEVELOPMENT

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: NARRATIVE Coronaviruses such as SARS-CoV-2 originate in animals and transmit to humans. New coronaviruses are discovered and sequenced from wildlife frequently, but, without effective laboratory tools to study these viruses, little is known about the zoonotic risk they pose to humans. We have developed several laboratory-based platforms to characterize the cell entry for hundreds of betacoronaviruses and propose to use these tools to annotate the ever-growing virome.

PI_NAMEs: HAN, BARBARA A.;LETKO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Amino Acids;Animals;Back;betacoronavirus;Binding;Birds;Cells;China;Chiroptera;Collaborations;Computer Models;Computing Methodologies;Coronavirus;coronavirus receptor;cost;cost efficient;cross-species transmission;Data;Data Set;Dependence;Deposition;design;Disease Outbreaks;Distal;experimental study;follow-up;future pandemic;gene synthesis;Genes;Genetic;Genome;Geography;Glycoproteins;Human;human coronavirus;improved;in silico;Infection;Invaded;Laboratories;Length;machine learning model;Mammals;Marketing;member;Merbecovirus;Methods;Middle East Respiratory Syndrome Coronavirus;Modeling;Molecular;next generation;next generation sequencing;novel;novel coronavirus;online repository;pandemic preparedness;particle;Pathogenicity;Peptide Hydrolases;Phenotype;Population;preference;Property;Proteins;Publishing;receptor;receptor binding;Receptor Cell;Reporter;Research;Research Personnel;Resistance;Risk;Route;Sarbecovirus;SARS coronavirus;screening;Silent Mutation;Surface;System;Technology;Testing;therapy resistant;tool;Training;transmission process;trend;universal coronavirus vaccine;Vaccines;Variant;Viral;virome;Virus;Virus Receptors;Work;Zoonoses

PROJECT_TITLE: Functional Viromics of Betacoronavirus Entry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 VDT-Q (01)]


ADMINISTERING_IC: DC

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Data Science;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: BALTIMORE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative  The application proposes a series of hands-on workshops focused on cognitive hearing (a.k.a. CogHear) that will advance the state-of-the-art readouts of mental states of listeners and their impact in advancing technologies and controlling hearing prosthetics as well as shaping the listening experience in everyday complex soundscapes. The workshops are organized around multidisciplinary groups of researchers spanning hearing, brain and cognitive scientists alongside data scientists and engineers. Groups will work in collaborative teams to explore scientific questions, pilot ideas, compare methodologies and brainstorm on new directions of research in the field in close partnership with industry stakeholders.

PI_NAMEs: ELHILALI, MOUNYA  (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Acoustics;Address;Adopted;Adult;Aging;Attention;attentional modulation;Auditory;Auditory Prosthesis;Awareness;Brain;broadening participation research;Cognition;Cognitive;cognitive function;cognitive process;Collaborations;Committee Members;Communication;Communities;Complex;computer scientist;computerized tools;Consensus;Data;Data Engineering;data mining;Data Scientist;Data Set;data sharing;design;Devices;Discipline;Educational workshop;Electroencephalography;Engineering;Environment;Event;experience;experimental study;Feedback;Fostering;Future;Geographic Locations;Goals;Hearing;Hearing Aids;hearing impairment;Human;Impairment;improved;Industry;Knowledge;meetings;member;mental state;Methodology;Methods;Mind;Minority;multidisciplinary;neural;next generation;Participant;Patient-Focused Outcomes;Perception;Peripheral;Population;portability;Process;prospective;Research;Research Personnel;robotic device;Role;Rotation;Science;Scientific Advances and Accomplishments;Scientific Inquiry;Scientist;Self-Help Devices;Semantics;Sensory;Series;Shapes;Signal Transduction;Speech;Structure;Students;System;Techniques;Technology;tool;Training;Translating;translational impact;translational potential;Underrepresented Minority;Underrepresented Populations;Voice;Woman;Work

PROJECT_TITLE: CogHear: Cognitive Hearing workshop series

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative A major diagnostic feature of alcohol use disorder is compulsive alcohol use despite negative consequences. Our goal is to determine the brain mechanisms that drive compulsive drinking after long-term exposure to alcohol. Here we examine how alcohol exposure alters recruitment of a brain pathway that is normally involved in constraining reward-seeking behavior in the face of negative consequences.

PI_NAMEs: RICHARD, JOCELYN M (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: activity marker;Affect;alcohol availability;Alcohol consumption;alcohol exposure;alcohol seeking behavior;alcohol use disorder;Alcohols;Anterior;basal forebrain;Behavior;Brain;brain pathway;cell type;Cells;Chemosensitization;Chronic;Consumption;Corpus striatum structure;Development;Diagnostic;drinking;experimental study;Fiber;Fluorescent in Situ Hybridization;Future;genetic approach;genetic manipulation;Globus Pallidus;Glutamate Receptor;glutamatergic signaling;Glutamates;Goals;Habenula;Hypothalamic structure;in vivo;Individual Differences;insight;Investigation;Lateral;Learning;Measures;Mediating;Messenger RNA;Modeling;Motivation;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neural;neural circuit;neural correlate;neuroadaptation;neurochemistry;neuromechanism;Neurons;neuroregulation;novel;Nucleus Accumbens;Outcome;Phenotype;Photometry;Play;Preoptic Areas;Quinine;Rattus;recruit;Regulation;Reporter;Research;Resistance;response;Rewards;Rodent;Role;sensor;Signal Transduction;single molecule;Testing

PROJECT_TITLE: Glutamatergic basal forebrain neurons in aversion-resistant drinking

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: Project Narrative The efficacy of cancer immunotherapy is dependent upon the generation of robust anti-tumor T effector cells. Novel strategies are needed to enhance the metabolic fitness of T cells at the level of precise biochemical reaction, molecular interactions, amenable to pharmacologic manipulation. We postulate that the bioavailability and the biosynthetic process of asparagine determines T cell robustness and anti-tumor function. This proposal will enable us to develop novel metabolic modulations on anti-tumor T effector cells to improve the efficacy and broaden the therapeutic horizons of immunotherapy.

PI_NAMEs: WANG, RUONING  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Adoptive Cell Transfers;Amino Acids;Anabolism;anti-tumor immune response;Antitumor Response;Asparagine;Aspartate-Ammonia Ligase;Automobile Driving;B-Cell Leukemia;Binding;Biochemical Reaction;biological adaptation to stress;Biological Availability;c-myc Genes;cancer cell;cancer immunotherapy;Cancer Patient;CAR T cell therapy;Carbon;cell growth;Cell Physiology;Cell Proliferation;Cellular Metabolic Process;Clinical;cytotoxic;Dependence;dietary approach;effector T cell;Energy Supply;Engineering;extracellular;Generations;Genetic;genetic approach;Glucose;Glutamine;Growth;immune checkpoint blockade;Immunologic Surveillance;Immunooncology;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Intervention;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Melanoma;Metabolic;metabolic fitness;Metabolic Pathway;Metabolism;metabolomics;Molecular;neoplastic cell;Nitrogen;Non-Small-Cell Lung Carcinoma;novel;novel strategies;Nutrient;Outcome;Outcome Assessment;Pathway interactions;patient response;pharmacologic;Pre-Clinical Model;Process;programs;Proliferating;Radioactive Tracers;Refractory;Regimen;Resources;response;Role;Signal Pathway;Signal Transduction;Source;Specificity;stable isotope;Stress;Stress Response Signaling;success;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;transcription factor;transcriptomics;treatment response;tumor;Tumor Immunity;tumor initiation;tumor microenvironment;uptake

PROJECT_TITLE: Modulation of asparagine bioavailability and stress response signaling to enhance T cell robustness and maximize immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Primary Health Care;Rehabilitation;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative: This project is consistent with NIAAA research priorities for behavioral and health services special interest in dissemination of evidence-based treatments for AUD in community settings and NOT-AA-19-010 on development and dissemination of behavioral treatments for AUD, and Advancing Science for the Health of Women: 2019-2023 Trans-NIH Strategic Plan,24 and is responsive to the VA 2018-2024 Strategic Plan25 to focus resources more efficiently and improve timeliness of services. The long-term objective is to produce an “off the shelf” treatment to fill a gap in evidence-based, accessible, patient-centered AUD treatment for women Veterans.

PI_NAMEs: EPSTEIN, ELIZABETH ELLEN (contact);HOLZHAUER, CATHRYN GLANTON;SMELSON, DAVID A

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Abstinence;Address;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol seeking behavior;alcohol use disorder;alcohol use initiation;Alcohols;Bacterial Artificial Chromosomes;Behavior;Behavior Therapy;Behavioral;brief intervention;Caring;chronic pain;Clinic;Clinical;Cognitive Therapy;community setting;comorbidity;Complex;Consolidated Framework for Implementation Research;Coping Skills;Counseling;Data;Development;Distress;drinking;Drug usage;effectiveness/implementation study;efficacy outcomes;Eligibility Determination;emotion regulation;Enrollment;Ensure;evidence base;Evidence based treatment;Female;fitness;formative assessment;Funding;Gender;Grant;Group Therapy;Health Sciences;Health Services;Health Services Accessibility;Healthcare;Healthcare Systems;Heavy Drinking;Human Resources;Hybrids;implementation barriers;implementation facilitators;implementation framework;improved;information gathering;interest;Intervention;Interview;Mediating;medical specialties;Mental Health;military veteran;mobile application;Modality;Modeling;Moods;Motivation;National Institute on Alcohol Abuse and Alcoholism;New York;novel;nutrition;Outcome;Outpatients;patient oriented;Persons;Pharmaceutical Preparations;preference;Primary Care;primary care patient;primary care provider;primary care setting;primary outcome;Process;programs;Provider;Randomized, Controlled Trials;relapse prevention;Reporting;Research;research and development;Research Design;Research Priority;Resources;response;screening, brief intervention, referral, and treatment;secondary outcome;segregation;Self Care;Services;Site;Sleep;Smoking;Social support;Special Population;Strategic Planning;Substance Use Disorder;support network;Testing;therapy development;Trauma;treatment as usual;treatment group;Treatment outcome;trial comparing;United States National Institutes of Health;Veterans;Veterans Health Administration;virtual;Woman;Women's Group;Women's Health;women's outcomes;women's treatment

PROJECT_TITLE: A Female-Specific Cognitive Behavioral Therapy Group for Alcohol Use Disorder in VA Primary Care Settings

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Prevention;Women's Health Research

ORG_CITY: IOWA CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The term “Satisfaction of Search” (SOS) refers to the phenomenon that one or more lesions are missed after a first lesion has been reported in an image, and SOS is responsible for up to 30% of all misses in the domains where it has been studied, such as chest radiology. However, SOS has never been studied in breast imaging, despite breast cancer being the most common type of cancer among women worldwide. In this project we will study SOS in full-field digital mammography (FFDM, a 2d image) and in Digital Breast Tomosynthesis (DBT, a pseudo-3d image), and determine the rate of these errors and their underlying causes.

PI_NAMEs: HOLLINGWORTH, ANDREW R;MELLO-THOMS, CLAUDIA R (contact);MOORE, CATHLEEN M

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Benign;Breast Cancer Detection;breast cancer diagnosis;breast density;breast imaging;cancer type;case control;Cause of Death;Chest;Cognitive;cognitive capacity;Collaborations;Collection;Data;Databases;Detection;Development;Diagnosis;Diagnostic;Diameter;Digital Breast Tomosynthesis;Digital Mammography;Dimensions;Disease;expectation;experimental study;Eye;Film;Foundations;Future;Goals;High Prevalence;Human;Image;Image Analysis;imaging modality;Impairment;improved;Incidence;Institution;interest;Investigation;Knowledge;Lesion;Location;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Measures;Medical Imaging;member;Memory;Methods;Modality;novel;Participant;Photography;Positioning Attribute;premature;Prevalence;Probability;programs;Pupil;radiologist;Radiology Specialty;Reader;Reading;Reporting;Research;Research Personnel;Resources;response;ROC Curve;satisfaction;screening;Screening for cancer;Signal Detection Analysis;Source;standard of care;Stimulus;Structure;Techniques;Technology;Thoracic Radiography;Three-Dimensional Image;Training;Training Programs;Triplet Multiple Birth;Visual;visual search;visual tracking;Woman;Work;X-Ray Computed Tomography;X-Ray Tomography

PROJECT_TITLE: Satisfaction of Search in Breast Cancer Detection

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Avoidant/restrictive food intake disorder (ARFID) is a serious mental and physical health condition which poses major public health problems due to severe impacts on growth, nutritional status, and psychosocial functioning. Although mechanisms that maintain problematic eating behaviors in ARFID are largely unknown, emotion dysregulation is common in eating disorders and our team’s newly developed cognitive-behavioral model of ARFID suggests that avoidant/restrictive eating is negatively reinforced via reductions in negative affect. The proposed multi-disciplinary study aims to determine the role of negative emotions in the maintenance of ARFID symptoms by first comparing activation in brain regions involved in emotion processing and key hormones related to emotional functioning between adults with ARFID and healthy adults, and second integrating real- time reports of negative emotions and avoidant/restrictive eating behaviors with neural circuitry and affect- related hormones to empirically evaluate the cognitive-behavioral model of ARFID.

PI_NAMEs: BECKER, KENDRA R (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Adult;Affect;Age;Amygdaloid structure;Anorexia Nervosa;Anterior;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;anxiety symptoms;Area;avoidant restrictive food intake disorder;Behavior;Behavioral Model;Biological;biological adaptation to stress;blood oxygen level dependent;Brain;Brain region;career development;Chronic;cingulate cortex;Circulation;Clinical;Cognitive;cognitive testing;Competence;Cues;Data;Data Analyses;Data Collection;depressive symptoms;design;Development;DSM-V;Eating;Eating Behavior;Eating Disorders;Ecological momentary assessment;emotion dysregulation;emotion regulation;Emotional;emotional functioning;emotional reaction;Emotions;Endocrine;Exhibits;Fasting;feeding;Female;Food;Food Aversion;food avoidance;food restriction;Formulation;Frequencies;Fright;Functional Magnetic Resonance Imaging;Funding;Gender;Goals;Growth;Hippocampus;Hormonal;Hormones;Hydrocortisone;Hyperactivity;Individual;innovation;Insula of Reil;interdisciplinary approach;interest;K-Series Research Career Programs;Maintenance;male;Malnutrition;Maps;Medial;Medical;medical complication;Mental Depression;Mental Health;Mentors;Methodology;Methods;Moods;Morbidity - disease rate;multidisciplinary;negative affect;Negative Reinforcements;neural circuit;Neuroanatomy;Neurobiology;Neurocognitive;Neuroendocrinology;Neurohormones;Nutritional status;Oxytocin;Pathology;patient oriented research;Patient Self-Report;Pattern;Peripheral;physical conditioning;Prefrontal Cortex;Prevalence;programs;psychiatric comorbidity;Psychopathology;psychosocial;Public Health;receptor;Reporting;Reproducibility;Research;Research Design;response;restrictive eating;Rewards;Role;Scientist;Sensory;Shapes;Signal Transduction;Standardization;Stimulus;Stress;Symptoms;Testing;Time;Training;trait;Treatment Cost;Variant;Weight;Youth

PROJECT_TITLE: The Role of Negative Affect in the Cognitive-Behavioral Model of Avoidant/Restrictive Food Intake Disorder: An Integrated Analysis of Neural Circuitry, Hormones, and Momentary Negative Emotions

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The activities proposed in this application will provide enhanced training in inter-disciplinary, experimental and quantitative research, and career development mentoring for predoctoral students and postdoctoral fellows pursuing careers in oncological sciences, with specific emphasis on quantitative and experimental cancer systems biology. The program includes specialized didactic coursework, multi-disciplinary research experiences, and technical and professional development opportunities designed to prepare trainees for success in the increasingly complex landscape of cancer systems biology.

PI_NAMEs: COUSSENS, LISA M. (contact);ZUCKERMAN, DANIEL M

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Integrated Training in Quantitative and Experimental Cancer Systems Biology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Primary care physicians are the gateway to reaching adult smokers but need resources to deliver evidence- based cessation treatment uniformly to all. The widespread adoption of Electronic Health Record (EHR) systems with coded smoking status data offers a ripe opportunity to proactively provide treatment. The present research project will test the clinical effectiveness and evaluate implementation of an asynchronous smoking cessation electronic visit that will be delivered proactively via the EHR to all adult smokers.

PI_NAMEs: DAHNE, JENNIFER RENEE (contact)

PROGRAM_OFFICER_NAME: REYES-GUZMAN, CAROLYN

PROJECT_TERMS: Abstinence;Academic Medical Centers;Address;Adoption;Adult;Algorithms;arm;Biochemical;Bupropion;Cancer Control;cancer prevention;care systems;Caring;Cessation of life;Cigarette;cigarette smoking;Clinic;Clinical;Clinical assessments;Clinical effectiveness;Clinical Trials;Code;Counseling;Data;Data Collection;digital;dissemination strategy;Drug Prescriptions;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;effectiveness trial;effectiveness/implementation trial;Electronic Health Record;electronic health record system;Environment;evidence base;Evidence based intervention;Evidence based treatment;eVisit;Familiarity;FDA approved;follow-up;Goals;Guidelines;Health Services Accessibility;Healthcare Systems;Hybrids;implementation barriers;implementation cost;implementation evaluation;implementation facilitators;implementation outcomes;improved;informant;information gathering;Intervention;Interview;Joints;Malignant Neoplasms;Methods;Modeling;Motivation;nicotine replacement;Outcome;Participant;Patients;Penetration;Pharmaceutical Preparations;Physicians;Pilot Projects;Practice Guidelines;premature;Prevalence;Primary Care;Primary Care Physician;primary care practice;primary care setting;Proctor framework;programs;Provider;psychosocial;Qualifying;quitline;Randomized;Recommendation;relative effectiveness;Reporting;Research;Research Project Grants;Resources;self help;Services;Site;Smoker;smoking cessation;Smoking Cessation Intervention;Smoking History;Smoking Status;Testing;Time;Tobacco use;tool;treatment as usual;Trust;United States;United States Centers for Medicare and Medicaid Services;United States Public Health Service;varenicline;Visit;Withholding Treatment

PROJECT_TITLE: Hybrid Type 1 Effectiveness-Implementation Trial of a Proactive Smoking Cessation Electronic Visit for Scalable Delivery via Primary Care

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Genetics;Mental Health;Neurodegenerative;Neurosciences;Prevention

PHR: PROJECT NARRATIVE Given the many recent failures of amyloid-lowering therapies in Alzheimer’s disease (AD), it is important to identify new mechanisms which may inform treatment targets. This proposal could lay the foundation for future large-scale AD prevention trials targeting HPA-axis reactivity in at-risk individuals.

PI_NAMEs: MUNRO, CYNTHIA ANN (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Acute;acute stress;Address;Alleles;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;apolipoprotein E-4;biological adaptation to stress;blood-based biomarker;Chronic stress;clinical application;Clinical Trials;Cognitive;cognitive testing;Consensus;disease heterogeneity;Distress;Endocrine;endophenotype;Executive Dysfunction;executive function;Failure;follow-up;Foundations;Functional disorder;Future;Genes;Genetic Polymorphism;Genotype;Heterogeneity;Hormones;Human;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Impaired cognition;Individual;interest;Intervention;Measures;Memory;Memory impairment;Memory Loss;men;Methods;middle age;mild cognitive impairment;Nerve Degeneration;Neurofilament-L;novel strategies;Older Population;Outcome;Patients;performance tests;Personality;Physiological;Plasma;polygenic risk score;Prevention trial;Production;Prospective Studies;Public Health;Research;Research Design;response;Risk;saliva sample;Sampling;sex;Sex Differences;Stress;Stress Tests;Stressful Event;stressor;System;Translating;treatment trial;Trier Social Stress Test;Woman;young adult

PROJECT_TITLE: Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Nutrition;Orphan Drug;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Glioblastoma (GBM) exhibit altered lipid metabolism to support rapid tumor growth and proliferation; thus, targeting lipid metabolism is a promising therapeutic strategy for GBM patients. Herein we propose to investigate how specific genetic alterations in GBM rewire lipid metabolism to expose new therapeutic vulnerabilities for ferroptosis- a lipid peroxidation-dependent form of cell death. The results obtained from this proposal could pave the way for novel therapeutic approaches to target lipid metabolism and promote ferroptosis within genetically-defined subsets of GBM tumors.

PI_NAMEs: BENSINGER, STEVEN J;DIXON, SCOTT ;NATHANSON, DAVID A. (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Adult;CDKN2A gene;Cell Culture Techniques;Cell Death;Cells;Cessation of life;cohort;Coupled;Couples;Data;DNA Sequence Alteration;Environment;Epidermal Growth Factor Receptor;Exhibits;exome;exome sequencing;Exposure to;fatty acid metabolism;Fatty Acids;Genes;Genome;Genotype;Glioblastoma;Growth;Head and Neck Cancer;Heterogeneity;Human;improved;In Vitro;in vivo;insight;Interdisciplinary Study;Investigation;Isotopes;Link;lipid biosynthesis;lipid metabolism;Lipid Peroxidation;lipidome;lipidomics;Lipids;loss of function;Malignant - descriptor;Malignant neoplasm of esophagus;Malignant Neoplasms;Measures;Medical;Melanoma;Metabolic;Metabolism;metabolome;Modeling;Modification;Molecular;Molecular Profiling;Monounsaturated Fatty Acids;mouse model;Mus;Mutation;next generation sequencing;novel;novel therapeutic intervention;novel therapeutics;Pathway interactions;Patients;Polyunsaturated Fatty Acids;Predisposition;Primary Brain Neoplasms;programs;Proliferating;RNA;Sampling;Shapes;Shotguns;Stable Isotope Labeling;standard of care;System;Testing;Therapeutic;Therapeutic Intervention;Tissues;transcriptome sequencing;tumor;tumor growth;Tumor Suppressor Proteins;tumorigenesis;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: CDKN2A couples lipid metabolism to ferroptosis in glioblastoma

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Clinical Research;Disability Research;Hematology;Immunization;Immunotherapy;Infectious Diseases;Sepsis;Vaccine Related

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project narrative Hospital-acquired infections and sepsis are major public health threats and difficult to treat and prevent. Therefore, new strategies are needed to decrease their burden on the American health care system. Immunotherapy aimed at inducing innate immune memory provides a means of achieving that goal. The proposed studies will examine the molecular mechanisms driving innate immune memory.

PI_NAMEs: SHERWOOD, EDWARD R (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Ablation;Aconitic Acid;Adaptive Immune System;Affect;Agonist;American;antimicrobial;Antimicrobial Effect;Automobile Driving;beta-Glucans;Biogenesis;Biology;Cause of Death;Cell Physiology;Cell Respiration;Cells;Cessation of life;Citric Acid;Citric Acid Cycle;Clinical;clinically relevant;cognitive disability;Complication;Critical Illness;cytokine;Death Rate;Development;Foundations;FRAP1 gene;gene product;Genes;Glycolysis;Goals;Healthcare Systems;high risk;Hospitals;Immune;immune resistance;Immune response;immune system function;Immunologic Memory;Immunotherapy;in vivo;Incidence;Individual;Infection;Innate Immune Response;Innate Immune System;Intensive Care Units;Knockout Mice;Knowledge;Leukocytes;Ligands;Lipid A;Long term physical disability;Macrophage;Memory;memory retention;Metabolic;metabolic phenotype;Metabolism;microbial;Mitochondria;mitochondrial metabolism;Modeling;Molecular;Myeloid Cells;Nosocomial Infections;organ injury;Organism;Oxidative Phosphorylation;pathogen;pathogen exposure;pathogenic bacteria;pathogenic fungus;Pathway interactions;Patients;Peptidoglycan;Phenotype;PIK3CG gene;Play;prevent;Production;programs;Pseudomonas aeruginosa;Public Health;recruit;Resistance;Resistance to infection;response;Role;Sepsis;severe burns;Severities;Signal Pathway;Signal Transduction;Staphylococcus aureus infection;surgical risk;Testing;TLR4 gene;Trauma;Vaccines;Vulnerable Populations

PROJECT_TITLE: Macrophage mitochodrial reprogramming and innate immune memory

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: Project Narrative Black women living with HIV (BWLWH; 40% unsuppressed) are marginalized and understudied, in the U.S. in general and in Miami, FL, a southern HIV epicenter. Our 1-year R56, occurring during the time of heighten visibility on racism in the U.S. and COVID-19, has further demonstrated the importance of longitudinally studying the unique role of microaggressions and frequent adversities (e.g. violence/trauma) in relation to HIV viral suppression among BWLWH. Our proposed study will allow for continued longitudinal data collection, and directly generate community-informed interventions to improve viral suppression among BWLWH; thereby helping us to move closer to Zero Infections, Zero Discrimination, and Zero AIDS-Related Deaths.

PI_NAMEs: DALE, SANNISHA K. (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Behavior;Black Populations;Black race;black women;Buffers;Caring;Cessation of life;Climate;Communities;community engaged intervention;community engagement;community partners;COVID-19;Data;Data Collection;Data Sources;Diagnosis;Discrimination;Domestic Violence;Ecological momentary assessment;Employment;Enrollment;Epidemic;experience;Female;Florida;Frequencies;Funding;Future;Grant;Hair;Health;Health behavior;HIV;HIV Seronegativity;HIV/AIDS;Housing;improved;Individual;Infection;information gathering;innovation;Intervention;intimate partner violence;Investigation;Lesbian Gay Bisexual Transgender Queer;Literature;Longitudinal Studies;marginalization;marginalized population;Measures;Mediating;medication compliance;Mental Depression;Mental Health;Methodology;microaggression;Modeling;Monitor;National Institute of Mental Health;Nature;neglect;Neighborhood Health Center;Neighborhoods;Outcome;Pathway interactions;Persons;physical assault;Population;Post-Traumatic Stress Disorders;Posttraumatic growth;Poverty;Published Comment;Race;racism;recruit;Reduce health disparities;Research;Research Priority;Research Support;resilience;resilience factor;Resources;response;Role;Self Efficacy;sexual assault;Shapes;Shelter facility;social structure;Social support;Spirituality;stressor;Stroke;substance use;success;Symptoms;Testing;Text Messaging;therapy development;Time;Trauma;trauma symptom;treatment disparity;Treatment outcome;United States National Institutes of Health;Violence;Viral;Visit;Voice;White Women;Woman;Women's Group;Women's study;Work

PROJECT_TITLE: Monitoring Microaggressions and Adversities to Generate Interventions for Change (MMAGIC) for Black Women Living with HIV

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Physical Injury - Accidents and Adverse Effects

ORG_CITY: HERSHEY

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE A rotator cuff tendon tear affects up to 64% of adults, resulting in muscular changes that drive functional disability and poor clinical outcomes, but little is known about the mechanisms driving poor function. The purpose of this study is to identify the structure-function associations of muscle and how they change over time after rotator cuff tear and surgical repair using an established rabbit model, and to develop a predictive model to further probe the mechanisms driving biomechanical function. Outcomes of this work will establish the structure-function associations of muscle after rotator cuff tear and expose the mechanisms and time points after injury that should be targeted by treatments to improve function for patients with a rotator cuff tear.

PI_NAMEs: VIDT, MEGHAN ELISE (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Adult;Affect;Animals;Architecture;Atrophic;Automobile Driving;Biological Assay;Biomechanics;Clinical;Closure by clamp;Computer Models;design;Development;Dissection;Elements;Euthanasia;extracellular;Failure;Fascicle;Fatty acid glycerol esters;Fiber;functional disability;functional improvement;Generations;Goals;improved;improved outcome;In Vitro;Individual;Infiltration;Inflammation;Injury;innovation;Intervention;Knowledge;Link;Lipids;Location;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;mechanical properties;Mechanics;Modeling;Morphology;MRI Scans;Multiscale Mechanics;Muscle;Muscle Fibers;muscle form;Muscle function;muscle stiffness;Muscular Atrophy;muscular structure;novel;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Outcome Study;patient population;Patient-Focused Outcomes;Patients;predictive modeling;Property;reduced muscle strength;repaired;Role;Rotator Cuff;rotator cuff tear;spatiotemporal;Structure;Structure-Activity Relationship;supraspinatus muscle;targeted treatment;Tendon structure;Testing;therapy design;Time;Work

PROJECT_TITLE: Biomechanics of muscle after rotator cuff tear: Multi-scale assessment of spatial and temporal effects

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: RALEIGH

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: NARRATIVE Overall Per- and polyfluoroalkyl substances (PFAS) are environmental contaminants of emerging concern because they are detected ubiquitously in our environment, yet there is little known about their toxicity, bioaccumulation, or effective remediation strategies. This proposed Center for Environmental and Health Effects of PFAS will integrate a cross-institutional team of leaders in the fields of environmental epidemiology, environmental science and engineering, toxicology, analytical chemistry, data science, and community engagement to address outstanding questions about PFAS exposure and human health in North Carolina and throughout the US. This Center is strongly aligned with the mandates of the Superfund Research Program and aims to couple integrative discovery-based research with community-driven needs to protect the public against unnecessary environmental health risks associated with PFAS exposure.

PI_NAMEs: MATTINGLY, CAROLYN J. (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Address;advanced analytics;Analytical Chemistry;Area;bioaccumulation;Biological;Biology;Cells;chemical property;Collaborations;combinatorial;Communities;community engagement;Community Health;community involvement;community partnership;Computational Technique;consumer product;Cosmetics;Data Analyses;data management;Data Science;data sharing;Detection;disease registry;empowerment;Ensure;Environment;Environmental Engineering technology;Environmental Epidemiology;Environmental Exposure;Environmental Health;Environmental Pollutants;Environmental Science;Epidemiology;Evaluation;exposed human population;Exposure to;forging;Fostering;Fright;Goals;Government;Health;health literacy;Health protection;Human;immune function;Immune system;Immunology;improved;Industrial Product;Infrastructure;innovation;Institution;instrumentation;Knowledge;Leadership;Liver;Malignant Neoplasms;Manufacturer;model organism;Mus;next generation;North Carolina;Organism;Pathway interactions;Poison;Poly-fluoroalkyl substances;Population;Prevention;Prevention strategy;programs;Public Health;remediation;Research;Research Project Grants;Research Support;Resistance;Resources;Risk;Scientist;Stains;Structure;Superfund;System;Technology;Thyroid Function Tests;Thyroid Gland;Toxic effect;Toxicology;Training;training opportunity;Translational Research;Trust;United States Environmental Protection Agency;Universities;Water;Zebrafish


NIH_SPENDING_CATS: Endocrine Disruptors

PHR: NARRATIVE  Administrative Core  Per- and polyfluoroalkyl substances (PFAS) are environmental contaminants of emerging concern because  they are detected ubiquitously in our environment, yet there is little known about their toxicity, bioaccumulation,  or effective remediation strategies. The Administrative Core of this proposed Center will be responsible for  ensuring coordination and efficient administrative and fiscal management of the Center to stimulate discovery-  based knowledge, and to facilitate research translation and help to inform preventive actions by community  and government stakeholders to protect human health.

PROJECT_TERMS: Address;Administrative Efficiency;Advisory Committees;Affect;Area;bioaccumulation;Center for Translational Science Activities;Collaborations;Communication;Communities;Community Actions;community center;community collaboration;community engagement;community partners;Complex;Cosmetics;Data;data sharing;Dedications;Detection;Development;Ensure;Environment;Environmental Engineering technology;Environmental Health;Environmental Pollutants;Environmental Protection;Environmental Science;experience;Exposure to;Feeds;fighting;Fire - disasters;Fostering;Foundations;Funding;Goals;Government;Grant;Health;Human;immunotoxicity;improved;Individual;Infrastructure;innovation;Institution;interest;Knowledge;Leadership;Measures;meetings;member;Methodology;next generation;North Carolina;Poly-fluoroalkyl substances;Population;Preventive;Preventive measure;Process;programs;remediation;Research;Research Personnel;Research Project Grants;Resources;Risk;Schedule;Scientist;Series;Services;Signal Recognition Particle;social media;success;Superfund;System;Technology;Technology Transfer;timeline;Toxic effect;Training;Translation Initiation;Translational Research;Translations;Universities;Visit;Voice;web site;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This proposal addresses a highly challenging and dynamic aspect and builds a novel paradigm of PP2A regulation, highlighting compelling mechanisms and hierarchy controls of holoenzyme biogenesis and recycling. This study will fundamentally advance our understanding of PP2A regulation, and provide novel principles and structural basis for beneficial control of PP2A function and regulation in human diseases and viral pathogenesis.

PI_NAMEs: XING, YONGNA  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Acceleration;Active Sites;Address;Affinity;Alzheimer's Disease;Back;base;Binding;Binding Sites;Biochemical;Biogenesis;Biological;Biophysics;cancer type;Catalytic Domain;Cell Cycle;Cell Death;Cell Physiology;Cells;chelation;Complex;Cryoelectron Microscopy;Data;demethylation;Disease;Dissociation;DNA Damage;Electrons;Enzymes;Exclusion;Family;Heart Diseases;Holoenzymes;Human;human disease;insight;interdisciplinary approach;Ions;Knowledge;Malignant Neoplasms;Mammalian Cell;Mediating;metalloenzyme;Metals;Methylation;Microscopic;Molecular;Molecular Chaperones;Molecular Conformation;Mutation;Names;nanomolar;Nervous System Disorder;novel;particle;pathogen;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological Processes;PPP2R4 gene;Predisposition;Process;protein folding;Protein phosphatase;Proteins;Publishing;Recycling;Regulation;Research;Resolution;response;Role;scaffold;Series;Signal Pathway;Signal Transduction;Structure;Viral Pathogenesis

PROJECT_TITLE: Structural and Cellular Choreography for Decommissioning and Recycling of PP2A Holoenzymes

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Data Science;Endocrine Disruptors;Networking and Information Technology R&D (NITRD)

PHR: NARRATIVE  DMAC  The Data Management and Analysis Core (DMAC) will manage the integration of data streams generated by the  Projects and Cores of the NC State Superfund Research Center. The DMAC aims lay out a data-centric approach  to synthesize this multi-scale integration into actionable discoveries that advance public health related to per-  and polyfluoroalkyl substances (PFAS). The translational impacts of DMAC will include new methods for tackling  the interface between environmental chemical sampling and resultant public health consequences, distributed  software to make these methods available to SRP teams addressing similar questions in other compound  families, and promotion of computational fluency in the next generation of Environmental Health Scientists.

PI_NAMEs: GRIFFITH, EMILY HOHMEISER (contact)

PROJECT_TERMS: Address;Bioinformatics;Biological Assay;Center for Translational Science Activities;cheminformatics;Collaborations;Communication;computational toxicology;computer infrastructure;Computer software;computerized tools;Computing Methodologies;computing resources;Data;data access;Data Analyses;Data Collection;Data Coordinating Center;data exchange;data integration;data interoperability;data management;Data Management Resources;data quality;Data Science;Data Scientist;data sharing;data standards;data streams;Databases;Dedications;Derivation procedure;design;Development;Documentation;Elements;environmental chemical;Environmental Health;experience;Experimental Designs;Extravasation;FAIR principles;Family;Fostering;Goals;Health;Human Resources;Individual;Interdisciplinary Communication;Leadership;Learning;member;Methods;Modeling;Monitor;next generation;novel;Ontology;Poly-fluoroalkyl substances;prevent;Process;programs;Public Health;Publishing;quality assurance;Quality Control;Reproducibility;Research;Research Personnel;Resources;Running;Sampling;Science;Scientist;Signal Recognition Particle;software development;Solid;Standardization;Structure;Superfund;Training;Training Activity;translational impact;user-friendly;Visual;Visualization;vulnerable community;Work

PROJECT_TITLE: Data Management and Analysis Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Endocrine Disruptors;Prevention;Social Determinants of Health

PHR: NARRATIVE  CEC  This Superfund (SRP) Center's Community Engagement Core (CEC) will work with communities along the Cape  Fear River in North Carolina who are impacted by per- and polyfluoroalkyl substance (PFAS) contamination in  drinking water. The CEC will help increase environmental health knowledge, so that residents can make  decisions to reduce their exposure to PFAS, and advocate for a healthier environment.

PI_NAMEs: MAY, KATLYN  (contact)

PROJECT_TERMS: Address;Advocate;Area;built environment;Chemicals;Chemistry;Classification;Collaborations;Communication;Communities;community academic partnership;community building;community center;community empowerment;community engagement;Community Health Education;community organizations;community partners;community research;Complex;Data;Data Analyses;data management;Decision Making;Development;drinking water;Education;Educational Materials;Environment;Environmental Health;Exposure to;forging;Fright;Funding;Grant;ground water;Health;health knowledge;health literacy;Human;improved;Individual;Information Networks;Infrastructure;innovation;Institution;Intervention;Link;Measures;member;Mission;Neurofibrillary Tangles;North Carolina;Persons;Policy Maker;Poly-fluoroalkyl substances;prevent;Prevention;Prevention strategy;programs;Property;Public Health;Public Participation;Research;Research Personnel;Research Project Grants;Research Support;Resistance;Resources;Scholarship;Science;scientific literacy;Scientist;social;Source;Stains;Students;Superfund;Surface;Techniques;Toxicology;Training;university student;Water;Work

PROJECT_TITLE: Community Engagement Core


PHR: NARRATIVE  RETCC  Understanding the environmental and health implications of emerging pollutants require an integration of  numerous expertise, including knowledge in multiple scientific disciplines, methodologies in data science, and  skills in community engagement. The primary goal of the Research Experience and Training Coordination Core  (RETCC) is to train pre- and post-doctoral trainees to become future leaders and scientists capable of  investigating and solving such environmental and health problems affecting communities.

PI_NAMEs: RANJITHAN, RANJI  (contact)

PROJECT_TERMS: Address;Affect;Animal Model;Bioinformatics;career development;Case Study;citizen science;cluster computing;Communication;Communities;community engaged research;community engagement;Complex;computational toxicology;Data Analyses;data management;Data Science;Development;Development Plans;Discipline;Educational workshop;Engineering;Environmental Health;Epidemiologist;Evaluation;experience;Future;Goals;Health;health literacy;human subject;improved;Individual;Informatics;Interdisciplinary Study;Intervention;Investigation;Journals;Knowledge;Learning;Mass Spectrum Analysis;meetings;Methodology;Mission;multidisciplinary;peer coaching;Policies;pollutant;Poly-fluoroalkyl substances;Postdoctoral Fellow;pre-doctoral;Preparation;programs;Research;Research Project Grants;Risk Assessment;Role;Science;Scientist;skills;summer research;Technology;tool development;Training;Training Programs;Work;Writing


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Estrogen;Menopause;Mental Health;Mental Illness;Prevention;Psychosis;Serious Mental Illness;Women's Health Research

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Women show a heightened risk for psychosis in midlife that is not observed in men. The menopausal transition, and its corresponding changes in estrogen and progesterone, may drive these differences in risk, yet data exploring these effects are wholly lacking. Isolating perimenopause as a critical risk period for psychosis and elucidating ovarian hormone mechanisms will substanatially increase understanding of disease susceptiblity and help identify novel targets for prevention and intervention efforts aimed at improving women's health.

PI_NAMEs: CULBERT, KRISTEN ;KLUMP, KELLY L (contact);THAKKAR, KATHARINE NATASHA

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Address;Affect;Age;age effect;Age Years;Area;Behavior;Behavioral;Brain;Categories;Chronology;critical period;Data;design;Diagnostic;Dimensions;direct application;Disease;Estradiol;Estrogens;Etiology;Event;experience;Health Policy;Hormonal;Hormones;improved;informant;innovation;Intervention;Longitudinal Studies;marijuana use;Measures;men;Menopausal Status;Menopausal Symptom;Menopause;Menstrual cycle;Methods;middle age;Modeling;Moods;Neurosecretory Systems;novel;Ovarian hormone;Patients;Perimenopause;Population;population based;Postmenopause;Premenopause;Prevalence;Prevention;Prevention approach;Prevention strategy;Procedures;Progesterone;prospective;Proxy;Psychoses;psychosis risk;psychotic;psychotic symptoms;Reporting;reproductive;Reproductive Periods;Research;Research Design;Research Personnel;response;Risk;Risk Factors;Role;saliva sample;Sample Size;Sampling;Steroids;Stress;stressor;Symptoms;Theory of Change;translational approach;Woman;Women's Health

PROJECT_TITLE: Hormonal Mechanisms of Perimenopausal Risk for Psychosis in Women


NIH_SPENDING_CATS: Bioengineering;Endocrine Disruptors

PHR: NARRATIVE  CAPTURE  CAPTURE is an integrated core facility which will support four projects relating to different aspects of PFAS  through the development and application of novel tools that will facilitate both untargeted and targeted  PFAS analyses. These capabilities will be accomplished using platform technologies with novel  analytical platforms and methods providing significantly improved limits-of-detection and novel algorithms to  focus on fluorinated species. The application of these integrated and state-of-the-art technologies will help  the Center define the role of PFAS in the environment and its affect on human health.

PI_NAMEs: BAKER, ERIN MARIE (contact)

PROJECT_TERMS: Address;Affect;Algorithms;Animals;Biological;Biological Models;Blood;Carbon;Chemicals;combinatorial;Communities;community engagement;Core Facility;dashboard;Data;Data Collection;Data Set;Databases;Decision Making;detection limit;Development;Doctor of Philosophy;Education;Electron energy loss spectroscopy;Electron Microscope;Electron Microscopy;Ensure;Environment;Environmental Pollutants;Evaluation;genome sciences;Genomics;Hazardous Chemicals;Health;high resolution imaging;Human;Human Resources;improved;Individual;innovation;instrumentation;interest;ion mobility;Ions;Knowledge;Laboratories;Length;lipidomics;Mass Spectrum Analysis;Measurement;metabolomics;Methods;Modernization;Molecular;Monitor;nanometer;novel;particle;Penetration;Phase;Phenotype;Poly-fluoroalkyl substances;Population;Procedures;Protocols documentation;PSSO3;public database;Qualifying;Reaction;Reagent;remediation;Research;Research Personnel;Resource Sharing;Role;Sampling;Scanning;Sex Differences;Signal Recognition Particle;Solid;species difference;Spectrum Analysis;Stable Isotope Labeling;Superfund;Techniques;Technology;technology platform;Tissues;tool;transcriptome sequencing;transcriptomics;translational engagement;transmission process;Urine;Variant;Water;Work;X ray spectroscopy;Zebrafish

PROJECT_TITLE: Core of Advanced Platform Technologies Used for Remediation and Exploration


NIH_SPENDING_CATS: Clinical Research;Endocrine Disruptors

PHR: NARRATIVE  (Biomedical Research) Research Project 1  Per- and polyfluoroalkyl substances (PFAS) are common drinking water contaminants in North Carolina, but  little is known about how long these chemicals stay in the body or what the human health impacts are. We  will study how PFAS levels change over time and how they are associated with thyroid disease. These  results will be useful for other communities and Superfund sites impacted by PFAS.

PI_NAMEs: HOPPIN, JANE  (contact)

PROJECT_TERMS: Address;Adult;Affect;Age;age group;Aging;Air;Antibodies;Back;Biological;Biomedical Research;Blood;Blood specimen;Body mass index;Characteristics;Chemicals;Child;Cholesterol;Clinic Visits;Clinical;cohort;Communication;Communities;community living;community partners;community partnership;community science;Complex;Complex Mixtures;Data;Data Set;Development;drinking water;Ensure;Excretory function;Exposure to;Fright;Future;Gender;Health;Health Personnel;Heart Rate;Human;Individual;insight;Life;Life Cycle Stages;manufacturing facility;Measures;Medical;meetings;Metabolic;Metabolism;Nafion;North Carolina;Obesity;Oral cavity;Outcome;Participant;Pattern;Persons;Plants;Poly-fluoroalkyl substances;Population;Population Heterogeneity;predictive modeling;Pregnant Women;Privatization;prospective;Protocols documentation;Public Health;Questionnaires;racial diversity;reconstruction;Recording of previous events;recruit;Regulation;Reporting;Research Personnel;Research Project Grants;Sample Size;Sampling;Sentinel;superfund site;Thyroid Diseases;thyroid disruption;Thyroid Function Tests;Thyroid Gland;Thyroid Hormones;Time;Toxicokinetics;United States;Universities;Urine;Variant;Water;Water Pollutants;Weight;Work

PROJECT_TITLE: PFAS Exposure and Thyroid Related Health Outcomes in Communities along the Cape Fear River, NC


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent syndrome and a major source of morbidity, mortality, and health care expenditures around the world. This proposal aims to elucidate mechanisms underlying HFpEF, focusing on mitochondrial function and metabolic changes. Studies proposed here will provide important insights into the pathogenesis of HFpEF and reveal potential therapeutic targets.

PI_NAMEs: TONG, DAN  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: 3-Hydroxyacyl-CoA dehydrogenase;Acetyl-CoA C-Acetyltransferase;Acetylation;Acetyltransferase;acyl-CoA dehydrogenase;Agonist;arginine methyl ester;Attenuated;Biological Assay;Cardiac;Cardiovascular Manifestation;Cardiovascular system;career;Clinical;Coenzyme A;Complement;Coupled;Data;Deacetylase;Defect;Diabetes Mellitus;effective therapy;EFRAC;Enoyl-CoA Hydratase;Enzymes;Equilibrium;experimental study;fatty acid oxidation;Fatty Acids;Foundations;Functional disorder;gain of function;Health Expenditures;Heart;Heart failure;High Fat Diet;Human;Hypertension;hypertensive;Immunoprecipitation;Impairment;In Vitro;insight;Investigation;Knock-out;Knowledge;Laboratories;Link;loss of function;Lysine;Mass Spectrum Analysis;Mechanical Stress;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic stress;Metabolic syndrome;Metabolism;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Morbidity - disease rate;mortality;mouse model;Mus;Myocardium;Neurodegenerative Disorders;Nicotinamide adenine dinucleotide;nicotinamide-beta-riboside;Nitric Oxide Synthase;novel;novel therapeutics;Obesity;Oral;Pathogenesis;Pathway interactions;Patients;Phenotype;Physicians;Post-Translational Protein Processing;Pre-Clinical Model;preservation;Protein Acetylation;protein function;Proteins;Proteomics;Research;Research Personnel;Research Project Grants;Rodent;Role;Scheme;Scientist;Secondary to;Sirtuins;skills;Source;Stress;Syndrome;Testing;Therapeutic Effect;therapeutic target;Tissues;Training;Work

PROJECT_TITLE: Protein acetylation-dependent fatty acid metabolic dysfunction in HFpEF

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: SAN FRANCISCO

ORG_NAME: OMVAX, INC.

PHR: Project Narrative Currently, there is no licensed vaccine in the US to prevent disease caused by Neisseria meningitidis serogroup B strains in less than 10 year olds, the age group at greatest risk of disease, and no licensed vaccine to prevent disease caused by Neisseria gonorrhoeae (Ng), which causes tens of millions of sexually transmitted infections annually. In addition, multiple antibiotic resistance has made Ng an urgent public health threat. We propose to develop a native outer membrane vesicle vaccine from Nm with over-produced Nm and Ng antigens that provides protection against disease caused by both pathogens in all age groups.

PI_NAMEs: MOE, GREGORY ROBERT (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: 10 year old;Address;Adolescent and Young Adult;Affect;Age;age group;Agreement;Animals;Antibiotic Resistance;Antibodies;Antibody Response;Antibody titer measurement;Antigen Presentation;Antigenic Variation;Antigens;Attenuated;Bacteremia;Bacterial Meningitis;bactericide;Binding;Binding Proteins;Bulla;CEACAM1;Cell Culture Techniques;Cells;Cervical;Characteristics;Child;Communities;Complement;Complement Factor H;Conjugate Vaccines;Data;Detergents;Development;Disease;Disease Outbreaks;disorder prevention;disorder risk;Effectiveness;Endotoxins;Engineering;Epithelial Cells;Epitopes;Estradiol;Event;experience;Female;Flow Cytometry;Fluorescence Microscopy;Goals;gonorrhea vaccine;Grant;Human;human pathogen;Immunity;Immunize;immunogenicity;Immunoglobulin G;Immunoglobulin M;Immunoprecipitation;Incidence;Individual;Infant;Infant Mortality;Invaded;Knock-out;Licensing;Life;Macaca;Macaca mulatta;Measures;Mediating;Membrane;Membrane Proteins;Meningitis;Microbial Biofilms;Modeling;mouse model;Mus;mutant;Nasal Epithelium;Neisseria;Neisseria gonorrhoeae;Neisseria meningitidis;Nose;novel;Nucleic Acids;overexpression;pathogen;Pathogenesis;Polysaccharides;Population;preservation;prevent;promoter;Proteins;Public Health;Publishing;Recombinant Proteins;Research;Research Personnel;resistant strain;Serogroup B Neisseria meningitidis;Serum;Sexually Transmitted Diseases;Structure;Surface;Symptoms;Testing;Toxic effect;Transgenic Mice;transmission process;vaccine platform;Vaccines;Vagina;Variant;Vesicle

PROJECT_TITLE: Meningococcal and gonococcal vaccine to prevent invasive disease and carriage

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Endocrine Disruptors;Immunotherapy

PHR: NARRATIVE (Biomedical Research) Research Project 2 Per- and polyfluoroalkyl substances (PFAS) are environmental contaminants of emerging concern resulting from point source (e.g., industrial and wastewater effluent) and non-point source (e.g., run-off and atmospheric deposition) inputs. Health effects observed in humans exposed to PFAS include cancer, liver toxicity, reproductive and developmental toxicity, and immunotoxicity; this project will explore molecular mechanisms underlying PFAS-induced immunotoxicity in animal models as well as human cell lines. Our goal is to identify impacted signaling pathways and networks that will accelerate development of immune therapies for affected individuals, inform appropriate regulatory measures, and facilitate novel, immune mechanism-based prioritization strategies for PFAS recently detected in North Carolina and elsewhere.

PI_NAMEs: KULLMAN, SETH WILLIAM (contact)

PROJECT_TERMS: Acceleration;Acids;Adaptive Immune System;adaptive immunity;Address;Affect;Air;Animal Experiments;Animal Model;animal model selection;Antibodies;Antibody Formation;Antigens;Assessment tool;Atmosphere;B-Cell Development;B-Lymphocytes;bioaccumulation;Bioenergetics;Biological;Biological Assay;Biomedical Research;Cause of Death;Cell Line;Cell Physiology;Cells;Chemical Structure;Chemicals;Chemotaxis;Chronic Disease;Communities;consumer product;Data;Deposition;Dermal;Development;developmental toxicity;Disease;disorder risk;drinking water;Embryo;Environment;Environmental Pollutants;Environmental Risk Factor;Event;experience;Experimental Animal Model;exposed human population;Exposure to;Flow Cytometry;Food;Frequencies;Future;Goals;hazard;Hazardous Substances;Health;Hepatotoxicity;Human;Human Cell Line;Immune;immune function;immune health;Immune response;Immune system;Immune System Diseases;Immunize;immunoregulation;Immunosuppression;Immunotherapy;immunotoxicity;Immunotoxicology;Impairment;improved;In Vitro;in vivo;in vivo Model;Individual;Industrial Product;Industrialization;Infection;Information Protection;Innate Immune System;Knowledge;Macrophage;Malignant Neoplasms;manufacture;Measures;Mediating;Metabolic;Metabolism;metabolome;metabolomics;migration;Mitochondria;Modeling;Molecular;mouse model;Mus;Natural Immunity;neutrophil;North Carolina;novel;Organism;Outcome;perfluorooctane sulfonate;Phagocytes;Phagocytosis;Plasma Cells;Poly-fluoroalkyl substances;Production;programs;Proliferating;Public Health;rapid technique;Reactive Oxygen Species;reproductive toxicity;Research;Research Project Grants;Resistance;Respiration;response;Risk;Risk Assessment;Risk Marker;Sampling;Serum;Signal Pathway;Signaling Protein;Site;Source;Stains;Superfund;T-Lymphocyte;Testing;Toxic effect;transcriptome;United States;Universities;vaccine response;Water;Work;Zebrafish

PROJECT_TITLE: Uncovering the Mechanisms of PFAS-induced Immunotoxicity


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Approximately 77,200 Americans will be diagnosed with non-Hodgkin’s lymphoma in 2020 and fewer than half will be cured with conventional treatments. Lymphomas are exquisitely sensitive to radiation and radiolabeled monoclonal antibodies can be very effective at inducing remission in most lymphoma patients, but the disease frequently recurs. This grant proposal describes the development of several innovations that combine radiolabeled antibodies with each other, or with other drugs, to prevent relapse by comprehensively eliminating every lymphoma cell.

PI_NAMEs: GREEN, DAMIAN J. (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: 90Y;absorption;Alpha Particles;American;anti-CD20;anti-tumor immune response;Apoptotic;Applications Grants;Astatine;B lymphoid malignancy;B-Cell Lymphomas;BCL1 Oncogene;BCL2L1 gene;Beta Particle;Biotin;cancer cell;Cancer Vaccines;CAR T cell therapy;Cell Death;cell injury;Characteristics;chimeric antigen receptor T cells;Clinical;clinical translation;Clone Cells;Combination Drug Therapy;combinatorial;Complement;conventional therapy;Deposition;Development;Diagnosis;Disease;Disease remission;Dose;Electromagnetic Energy;experience;Funding;Goals;Grant;Head;Hematologic Neoplasms;Heterogeneity;high risk;human model;Immune;Immune checkpoint inhibitor;Immune response;Immunocompetent;immunogenicity;Immunotherapy;improved;In complete remission;Indolent;inhibitor;innovation;Intervention;Isotopes;large cell Diffuse non-Hodgkin's lymphoma;Length;Linear Energy Transfer;Lymphoma;Lymphoma cell;MCL1 gene;Methods;mimetics;Modeling;Molecular;Monoclonal Antibodies;Monoclonal Antibody CD20;mouse model;Myeloablative Chemotherapy;neoplastic cell;Non-Hodgkin's Lymphoma;novel;Organ;Outcome;particle;particle therapy;Patients;Peptides;peptidomimetics;Pharmaceutical Preparations;programs;Radiation;Radiation Dose Unit;Radiation therapy;Radioimmunoconjugate;Radioimmunotherapy;Radioisotopes;Radiolabeled;Radionuclide therapy;Recurrence;Refractory;Relapse;relapse prevention;Remission Induction;Reporting;Research Proposals;Reserve Cell;Residual Neoplasm;Residual state;Resistance;response;Site;stem cells;Streptavidin;success;Supporting Cell;synergism;Testing;Therapeutic Index;tositumomab;Toxic effect;transcriptome sequencing;Translations;Treatment Efficacy;tumor;Tumor Antigens;Tumor Debulking;tumor xenograft;United States;virtual;Visualization;Work

PROJECT_TITLE: Radioimmunotherapy Combinations for B-cell Malignancy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is progressive neurodegenerative disorder characterized by the extracellular accumulation of amyloid β (Aβ) deposits and the formation of intracellular tau-containing neurofibrillary tangles in the brain. This proposal aims to develop the near-infrared optical probes and instrumentation that will enable, for the first time the non-invasive monitoring of the dynamics of these pathological protein aggregates in AD mouse models with cellular resolution. The developed tools and techniques will represent a significant advance in our ability to assess therapeutic strategies when conducting preclinical mouse studies in AD.

PI_NAMEs: HOU, STEVEN S. (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: abeta accumulation;Affinity;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Animals;Antibodies;APP-PS1;Binding;Biodistribution;Blood Vessels;blood-brain barrier crossing;Brain;candidate identification;Chemical Structure;cost;cranium;Custom;DAP kinase;Dependence;Deposition;Derivation procedure;Development;Disease Progression;Drug Kinetics;Dyes;Early Diagnosis;efficacy study;Environment;Enzymes;extracellular;Fluorescence;Fluorescent Dyes;Fluorescent Probes;fluorophore;General Hospitals;Human;Image;imaging approach;imaging biomarker;imaging modality;imaging study;imaging system;Impaired cognition;In Vitro;in vivo;in vivo evaluation;in vivo imaging;Individual;inhibitor;instrumentation;International;Label;Leadership;Libraries;Magnetic Resonance Imaging;Massachusetts;Measures;medical schools;Memory impairment;Mentored Research Scientist Development Award;Mentors;Methods;Microscope;Microscopic;microscopic imaging;Modeling;molecular imaging;Monitor;mouse model;Multi-modal optical imaging;multi-photon;multimodality;multiphoton microscopy;Mus;Near-infrared optical imaging;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;neuropathology;non-invasive imaging;non-invasive monitor;non-invasive optical imaging;Nonionizing Radiation;novel;optical imaging;optical spectra;Optics;Pathologic;Pathway interactions;Patients;Penetration;Performance;Photons;Positron-Emission Tomography;pre-clinical;Property;protein aggregation;Quantitative Structure-Activity Relationship;Research;Research Personnel;Resolution;Resources;Scalp structure;Senile Plaques;simulation;single photon emission computed tomography;skills;Skin;small molecule libraries;Structure;System;tau aggregation;tau Proteins;Techniques;Testing;theranostics;Therapeutic;Therapeutic Effect;Time;Tissues;tool;Training;Transgenic Mice;treatment response;tumor;Validation;Work

PROJECT_TITLE: Optical probe and instrumentation development for in vivo near-infrared fluorescence imaging of Alzheimer's disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


PHR: NARRATIVE  (Environmental Science and Engineering) Research Project 3  This project will leverage laboratory and field studies to fill critical gaps in our understanding of likely routes of  exposure, kinetics of uptake and elimination, and toxicity profiles of a select group of replacement per- and  polyfluoroalkyl substances (PFAS) of emerging concern.

PI_NAMEs: PLANCHART, ANTONIO J. (contact)

PROJECT_TERMS: Address;Affect;Age;Alligators;Apical;aquatic organism;aqueous;bioaccumulation;Biology;chemical release;Chemical Structure;Chemicals;Clinical;Cohort Studies;Consumption;Controlled Study;Diet;dietary;drinking water;Ecosystem;Environment;Environmental Engineering technology;Environmental Science;Evaluation;experimental study;exposed human population;exposure pathway;exposure route;Exposure to;field study;Fishes;Food;Food Webs;Fresh Water;Fright;Future;Generations;Goals;Hazard Assessment;Health;Human;immune function;Individual;Investigation;Kinetics;Laboratories;laboratory experiment;Laboratory Study;Life;Link;manufacturing facility;Measures;Modeling;Movement;Nature;nutrition;Organism;Outcome;Persons;Phase;Poly-fluoroalkyl substances;predictive modeling;Production;Reporting;Research;Research Project Grants;Resources;Risk Management;Safety;Sampling;Source;Structure;Superfund;Testing;Tissues;Toxic effect;Uncertainty;uptake;Water;Work;Zebrafish

PROJECT_TITLE: Integrating experimental and field studies to understand PFAS bioaccumulation and impact in aquatic food webs


ORG_CITY: ALBUQUERQUE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative This is a new application for a training program supporting predoctoral trainees in biomedical research at the University of New Mexico Health Sciences Center. Program strengths include a recruitment strategy targeted at multiple underrepresented minority (URM) serving institutions in New Mexico and the Southwest region, the formation of Learning Communities to support special needs of URM trainees and career training in non-academic research areas. These strengths will enhance retention and increase potential careers paths open to IMSD trainees, preparing highly skilled biomedical scientists from backgrounds underrepresented in biomedical research to increase workforce diversity.

PI_NAMEs: KANAGY, NANCY L (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Initiative to Maximize Student Diversity at the University of New Mexico Health Sciences Center 2021

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


PHR: NARRATIVE  (Environmental Science and Engineering) Research Project 4  Per- and polyfluoroalkyl substances (PFAS) are environmental contaminants of emerging concern, and  effective PFAS remediation technologies are needed for a wide range of applications. This project will describe  mechanisms of PFAS sorption to granular activated carbon (GAC). Results of this project will contribute to  lower remediation costs, safer management of spent GAC, and cleaner drinking water, which will ultimately  reduce human exposure.

PI_NAMEs: KNAPPE, DETLEF R (contact)

PROJECT_TERMS: Address;Adsorption;Affect;Air;aqueous;Black Box;Carbon;Characteristics;Communities;community engagement;Consumption;contaminated drinking water;cost;Coupled;Data;design;Development;Diffusion;Dimensions;drinking water;Effectiveness;Electron energy loss spectroscopy;Environmental Engineering technology;Environmental Pollutants;Environmental Science;Environmental sludge;Equilibrium;Evaluation;Excision;experimental study;exposed human population;Film;Foundations;Goals;Guidelines;Health;improved;Industrialization;innovation;insight;ion mobility;Isotopes;Kinetics;Laboratories;laboratory experiment;landfill;Life;Link;Mass Spectrum Analysis;mathematical model;Microscopy;Modeling;Municipalities;North Carolina;organic contaminant;particle;Particle Size;Penetration;perfluorooctane sulfonate;perfluorooctanoic acid;Persons;Plants;pollutant;Poly-fluoroalkyl substances;predictive modeling;Preventive;Process;Production;programs;Property;Public Health;Radial;remediation;Research;Research Project Grants;scale up;Scanning Electron Microscopy;Scanning Tunneling Microscopy;Services;Sewage;Site;Source;Sum;Superfund;Surface;System;Technology;Testing;United States;Universities;X ray spectrometry

PROJECT_TITLE: Uncovering Mechanisms of PFAS Adsorption by Granular Activated Carbon to Support PFAS Remediation


NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Chlamydia is a major cause of sexually transmitted infections in the U.S., and more chlamydial infections are reported to the CDC each year than all other infectious diseases combined. This project will study how conversion between the dividing and infectious forms of chlamydiae is controlled by chlamydial size as an intrinsic signal for conversion, or by alternative mechanisms that utilize extrinsic signals provided by the inclusion membrane or the chlamydial population within an infected cell.

PI_NAMEs: BOASSA, DANIELA ;ENCISO, GERMAN ANDRES;SUETTERLIN, CHRISTINE  (contact);TAN, MING

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: 3-Dimensional;Affinity;Antibiotics;Bacteria;Binding;Binding Sites;Cells;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;chromatin immunoprecipitation;Communicable Diseases;Communication;computer studies;Contact Inhibition;Data;Development;DNA Binding;Electron Microscopy;Event;experimental study;Gene Expression;Genes;genetic approach;genital infection;Growth;human disease;Individual;Infection;innovation;Interruption;Intervention;Intrinsic factor;mathematical model;Measures;Membrane;Modeling;Morphology;novel;novel therapeutic intervention;pathogen;Population;Production;Publishing;Reporting;Role;Sexually Transmitted Diseases;Signal Transduction;Site;temporal measurement;Testing;therapeutic target;Time;Titrations;transmission process;Vacuole

PROJECT_TITLE: Mechanism of RB-to-EB Conversion in Chlamydia

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Traumatic brain injury (TBI) remains a public health concern, the consequences of which can lead to long-lasting disability and cognitive dysfunction. Inflammation after TBI can serve both beneficial and detrimental roles, with uncontrolled inflammation profoundly influencing neuronal survival and outcome. The present proposal will investigate the role of the neuropeptide CART (cocaine and amphetamine regulated transcript) in the regulation of inflammation after TBI, and if this neuropeptide can be used to reduce TBI pathophysiology and improve cognitive outcome.

PI_NAMEs: DASH, PRAMOD K (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acetylcholine;Acute;Address;alpha-bungarotoxin receptor;Animals;Anti-Inflammatory Agents;Attenuated;axon injury;Binding;Blood;blood-brain barrier permeabilization;Brain Diseases;Brain Injuries;Brain Pathology;Brain Stem;CARTPT gene;Cations;Cells;Cholinergic Receptors;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;cytokine;desensitization;disability;Disease;dorsal motor nucleus;Dose;experimental study;Female;Functional disorder;G-Protein-Coupled Receptors;Half-Life;Hour;Human;Immune;immune cell infiltrate;immunoreactivity;Impaired cognition;improved;Infiltration;Inflammation;Inflammatory;Injections;Interleukin-1 beta;intraperitoneal;Intravenous;intravenous administration;Learning;Lipopolysaccharides;male;Measures;Mediating;Memory;Memory impairment;Modeling;mortality;Mus;Nerve;Nerve Degeneration;neuron loss;neuronal survival;Neurons;Neuropeptides;neuroprotection;Neurotransmitters;Organ failure;Outcome;Pathology;Peptide antibodies;Peptides;Peripheral;Persons;Public Health;Quality of life;receptor;Regulation;Reporting;Research;Rodent;Role;screening;Second Messenger Systems;Secondary to;Sepsis;Serum;sex as a biological variable;Site;Spleen;System;TBI treatment;Testing;therapeutic evaluation;Time;TNF gene;transcriptome sequencing;Traumatic Brain Injury;vagus nerve stimulation;Vagus nerve structure

PROJECT_TITLE: Role of Peripheral Inflammation in TBI Pathobiology

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Effectively tackling the many complex factors that influence human health and disease requires the mobilization of the broadest talent base, comprised of individuals with different backgrounds, perspectives and talents. Yet, despite advances over the last few decades, the diversity of biomedical workforce does not reflect the broader population and therefore fails to tap into vast resources of available talent. The proposed training program seeks, in its small measure, to alleviate that lack of diversity by providing academic, research, professional development and networking activities that spur the recruitment, retention and excellence of individuals from backgrounds traditionally underrepresented in the biomedical sciences, and by so doing, improve the health of the population of the United States.

PI_NAMEs: LAPANE, KATE L;LEWIS, BRIAN C (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: IMSD at the University of Massachusetts Medical School


NIH_SPENDING_CATS: Biotechnology;Cancer;Lung;Lung Cancer;Orphan Drug;Rare Diseases

PHR: Project Narrative  Cancers use two different types of transporters to take up the glucose they need to grow: SGLT2 and GLUT1; we found that early-stage lung cancers use SGLT2, while more advanced lesions switch to GLUT1. We are going to investigate the metabolic function of the switch between SGLT2 and GLUT1, and the mechanisms by which the cells can induce this switch. This is relevant because metabolic inhibition is at the basis of novel targeted therapies for lung cancer, but the switch from one transporter to the other represents a strategy of cancer cells to develop resistance to therapy, which needs to be addressed in order to improve patient survival.

PI_NAMEs: SCAFOGLIO, CLAUDIO  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Address;aerobic glycolysis;Agreement;Area;Biological;cancer cell;Cancer Etiology;cancer therapy;Carcinoma;Cell Differentiation process;Cell Line;Cell Respiration;Cells;Cellular Metabolic Process;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;constitutive expression;Coupled;Data;Development;Distal;Engineering;Evaluation;fluorodeoxyglucose;Genetically Engineered Mouse;Glucose;glucose metabolism;glucose transport;Glucose Transporter;glucose uptake;Glutamine;glycogen synthase kinase 3 beta;Glycolysis;Goals;Growth;Heterogeneity;HIF1A gene;Histology;Hypoxia;Hypoxia Inducible Factor;Immunohistochemistry;improved;In Vitro;in vivo;inhibitor;Insulin;Knock-out;Lesion;Lung;Lung Adenocarcinoma;lung carcinogenesis;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Membrane Potentials;Metabolic;metabolic phenotype;Metabolism;metabolomics;Mitochondria;mitochondrial membrane;mitochondrial metabolism;Modality;Molecular;Morphology;Mus;new therapeutic target;Nodule;novel;novel therapeutics;overexpression;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phenotype;Phosphotransferases;Pimonidazole;Play;Population;Positron-Emission Tomography;premalignant;progenitor;programs;Proto-Oncogene Proteins c-akt;Regulation;Research;Resistance development;resistance mechanism;Role;SLC2A1 gene;Sodium;Spirometry;System;Testing;therapy resistant;tool;TP53 gene;Tracer;transcriptomics;transgene expression;treatment response;tumor;tumor growth;Tumor stage;uptake;Warburg Effect

PROJECT_TITLE: Investigating the heterogeneity of glucose transport in lung adenocarcinoma


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: LEXINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Alcohol misuse and related risky sexual behavior are significant public health concerns among college students. This project involves (1) adapting and evaluating a technology-delivered behavioral intervention that is designed to reduce alcohol misuse and related risky sexual behavior among first-year college students while also (2) examining factors important to intervention implementation in college settings. If effective, the intervention may be widely disseminated and has the potential to make a positive impact on college student health.

PI_NAMEs: RAY, ANNE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Alcohol consumption;alcohol misuse;alcohol prevention;Alcohols;Area;Behavior;behavior change;Behavior Therapy;Behavioral;binge drinking;Clinical;college;commercialization;Data;Data Collection;design;Development;diaries;drinking;Effectiveness;effectiveness evaluation;effectiveness/implementation design;effectiveness/implementation study;effectiveness/implementation trial;eHealth;Ensure;Event;evidence base;experience;Feedback;flexibility;Focus Groups;follow-up;formative assessment;Future;group intervention;Health;Heavy Drinking;high intensity drinking;high risk;high risk sexual behavior;Hybrids;implementation determinants;implementation intervention;improved;Individual;innovation;Intervention;intervention effect;Link;Literature;Mind;Monitor;Motivation;National Institute on Alcohol Abuse and Alcoholism;Nature;online delivery;Outcome;Participant;Pathway interactions;Pattern;Persons;post implementation;Prevention strategy;Process;programs;Public Health;Randomized, Controlled Trials;Reporting;Research;Research Design;response;Risk;Sampling;scale up;Self Efficacy;sex;Sex Behavior;sexual victimization;sexually active;Site;Students;success;System;Target Populations;Technology;Testing;Time;Universities;university student;Unsafe Sex;usability;web-based assessment;Work

PROJECT_TITLE: Cross-Tailoring Integrative Alcohol and Risky Sex Feedback for College Students: A Hybrid Type 1 Effectiveness-Implementation Trial

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Many people at high risk of HIV in the United States and globally are not reached by existing prevention programs. Online interventions can reach and engage individuals into HIV treatment and prevention, but few effective models exist anywhere. Therefore, it is important to develop clinically proven online prevention programs to engage people at high HIV risk and prevent new infections.

PI_NAMEs: PATEL, VIRAJ V (contact)

PROJECT_TERMS: Acceleration;Address;Affect;AIDS prevention;Anti-Retroviral Agents;Area;Attention;Awareness;Behavior;Behavior Therapy;Behavioral;Caring;Clinical;Communication;Communities;community organizations;Continuity of Patient Care;Counseling;Data;design;digital;efficacy evaluation;Epidemic;Ethics;evidence base;experience;Facebook;follow-up;Friends;Fright;gender minority community;General Population;global health;Goals;Health;high risk;high risk men;HIV;HIV Infections;HIV risk;HIV Seronegativity;Home;Human immunodeficiency virus test;improved;India;Individual;Infection;innovation;Intention;Internet;Intervention;Knowledge;Link;Measures;men who have sex with men;Methods;mobile computing;Modeling;Motivation;NIH Office of AIDS Research;online intervention;Outcome;outreach;Participant;Patient Self-Report;peer;Persons;Pilot Projects;Population;Populations at Risk;pragmatic randomized trial;pre-exposure prophylaxis;Prevalence;prevent;Prevention;Prevention program;Prevention strategy;preventive intervention;Privatization;Professional counselor;programs;Questionnaires;Randomized;Randomized, Controlled Trials;Records;recruit;Research;Research Priority;research study;Risk;same sex behavior;self testing;Sexual and Gender Minorities;Sexual Health;sexually active;Site;skills;social;social media;social stigma;Socialization;Target Populations;Technology;technology intervention;Test Result;Testing;Text;theories;therapy design;three-arm trial;treatment strategy;trial comparing;Trust;United States;United States National Institutes of Health;uptake;web page;week trial

PROJECT_TITLE: CHALO!: A mobile technology based intervention to accelerate HIV testing and linkage to prevention and treatment

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative With nearly 40,000 children suffering from Dravet Syndrome in desperate need of more effective therapies, and families moving to Colorado based almost on a blind hope for a new treatment, our proposal is squarely focused on a timely and significant unmet need in the pediatric epilepsy community. Combining multiple levels of analysis across several zebrafish models of DS, this proposal aims to provide new insights and treatment for this condition.

PI_NAMEs: BARABAN, SCOTT C (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Agonist;analog;analysis pipeline;Award;Behavior;Behavioral;Benchmarking;Biological Assay;blind;Blinded;Brain;Calcium;calcium indicator;Cells;Child;childhood epilepsy;Clinical;Colorado;Communities;comorbidity;confocal imaging;Convulsants;CRISPR/Cas technology;de novo mutation;design;Development;Disease;dravet syndrome;drug candidate;drug development;drug discovery;Drug resistance;drug use screening;effective therapy;Electrodes;Electrophysiology (science);Elements;Epilepsy;Etiology;excitatory neuron;Exhibits;Failure;Family;Functional disorder;Gene Mutation;Generations;Genetic;genome editing;Goals;Heterozygote;high risk;high-throughput drug screening;Human;Image;Imaging Techniques;Impairment;improved;in vivo;inhibitory neuron;insight;Investigation;kinase inhibitor;Larva;Libraries;Locomotion;loss of function;manufacture;Metabolic dysfunction;Microfluidics;Modeling;multidisciplinary;mutant;Mutation;National Institute of Neurological Disorders and Stroke;neural network;novel;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Pharmacology Study;Phenotype;preclinical development;preclinical study;receptor;Research;research and development;Resistance;Resolution;SCN1A protein;screening;Seizures;Serotonin;severe intellectual disability;side effect;Signal Pathway;Social Development;Sodium Channel;sudden unexpected death in epilepsy;Techniques;Technology;Time;tool;Transgenic Organisms;voltage;Work;Zebrafish

PROJECT_TITLE: ZEBRAFISH MODELS FOR DRAVET SYNDROME RESEARCH AND DISCOVERY

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]