NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Diabetes;Nanotechnology;Regenerative Medicine;Wound Healing and Care

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: NARRATIVE Chronic wounds are responsible for $25 billion USD in annual expenditures in the United States and are the most common cause of lower extremity amputation. Diabetes is a major risk factor for non-healing wounds, and an excessive inflammatory phenotype of macrophage cells in the diabetic state is implicated as a causative factor that impairs tissue repair. In this project, a nanomedicine strategy will be developed to selectively deliver therapeutic agents to macrophages locally in wounds to inhibit their inflammatory phenotype and promote repair, while avoiding effects on structural cells in wounds as well as distant tissues.

PI_NAMEs: GALLAGHER, KATHERINE ANN;SMITH, ANDREW MICHAEL (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acute;acute wound;Address;Amputation;angiogenesis;Animal Model;Anti-Inflammatory Agents;Biomedical Engineering;Caring;Cell Physiology;Cell Therapy;Cells;Cellular biology;Cellular Immunology;Chemistry;Chronic;chronic wound;Clinic;Clinical;Clinical Research;clinical translation;Complex;Coxibs;cytokine;Data;Debridement;Dextrans;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;diabetic ulcer;diabetic wound healing;Dinoprostone;Distant;Drug Carriers;Drug Delivery Systems;drug development;drug release kinetics;Drug Targeting;efficacy evaluation;Engineering;Ensure;Evaluation;Exhibits;Expenditure;extracellular;Failure;Flow Cytometry;Fluorescence Microscopy;Formulation;Goals;Granulation Tissue;Growth Factor;healing;Human;Hydrogels;Image;imaging agent;imaging probe;Immune;immunoregulation;Impaired healing;Impaired wound healing;Impairment;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;lead candidate;Lower Extremity;Macrophage;Measures;Mediating;Molecular Immunology;molecular pathology;Molecular Target;monocyte;mouse model;multimodality;Mus;nanocarrier;nanoengineering;nanolabel;nanomaterials;nanomedicine;Nature;non-diabetic;non-healing wounds;Non-Insulin-Dependent Diabetes Mellitus;novel;nuclear imaging;Outcome;pathogen;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Polysaccharides;pre-clinical;Pre-Clinical Model;preclinical development;prevent;primary outcome;Process;Prostaglandins;PTGS2 gene;Radioisotopes;radiopharmacology;Reactive Oxygen Species;receptor;recruit;Regulation;Regulatory Pathway;release factor;repaired;Reporting;research clinical testing;Risk Factors;Role;Route;side effect;standard of care;systemic toxicity;targeted delivery;targeted imaging;Test Result;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Time;tissue repair;Tissues;Translating;Translations;Treatment Efficacy;United States;uptake;Vasodilator Agents;Work;wound;wound closure;wound healing;Wound models

PROJECT_TITLE: Nanomedicine-Based Targeting of Inflammatory Macrophages in Diabetic Wound Repair

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Columbus

ORG_COUNTRY: UNITED STATES

ORG_DEPT: VETERINARY SCIENCES

ORG_FIPS: US

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: OVERALL PROJECT NARRATIVE The ultimate goal of this P01 Program Project Grant (PPG) competitive renewal application is to utilize the HTLV-1 T-cell immortalization model to gain understanding of the microenvironmental, cellular and viral factors that lead to progression to leukemia, and with this knowledge, to identify unique targets for diagnosis and treatment of HTLV-1 infection and ATL and related leukemia/lymphoma.

PI_NAMEs: GREEN, PATRICK LEE (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: adult T-cell leukemia cell;Adult T-Cell Leukemia/Lymphoma;Animals;anti-cancer research;Area;Binding Proteins;Binding Sites;Biological;Biometry;cancer cell;Cancer Model;cancer therapy;CCCTC-binding factor;CD4 Positive T Lymphocytes;cell immortalization;Cells;Diagnosis;Disease;Disease Progression;Disseminated Malignant Neoplasm;DNA Sequence Alteration;Event;Functional disorder;Funding;Goals;Grant;Human;Human T-lymphotropic virus 1;improved;Infection;Knowledge;leukemia;leukemia/lymphoma;leukemogenesis;Lymphocyte Activation;Lymphoma;Lymphoproliferative Disorders;Malignant - descriptor;Malignant Neoplasms;Messenger RNA;Modeling;neoplastic;new therapeutic target;novel therapeutics;Osteolytic;Outcome;Pathogenesis;Pattern;Play;Positioning Attribute;preneoplastic cell;Program Research Project Grants;programs;Proteins;Provirus Integration;response;Retroviridae;Retroviridae Infections;Role;Syndrome;T-Lymphocyte;Viral;Viral Vector;Virus;Virus Diseases;Virus Latency;Work;Zinc Fingers

PROJECT_TITLE: Retrovirus Models of Cancer


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Because helping address the needs of ADRD patients requires substantial long-term behavioral and social care supports not typically provided under traditional fee-for-service insurance, covering a broader set of services and coordination care for enrollees with managed care may be expected to improve patient outcomes while restraining health care use. However, little is known about the role of managed care in dementia care, including the extent to which ADRD individuals are using managed care products, the types of plans they use, whether caregivers influence such decisions, and whether managed care enrollment is associated with improvements in outcomes for individuals with ADRD or changes in the amounts and type of informal care received. We will assess managed care uptake and its impact on patients and their use of informal caregiving, using instrumental variables analysis with Medicare data plus national survey data.

PI_NAMEs: HOFFMAN, GEOFFREY JONATHAN (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Affect;Alzheimer's disease care;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Behavioral;care coordination;care recipients;care systems;Caregiver Burden;Caregiver support;Caregivers;caregiving;Caring;Characteristics;Clinical;Cognitive;cost;Data;Data Set;Dementia;dementia burden;dementia care;dementia caregiving;Disease;dissemination strategy;Enrollment;Family;Family Caregiver;family caregiving;Fee-for-Service Plans;Financial Hardship;Friends;Grant;Health;Health and Retirement Study;Healthcare;Healthcare Systems;improved;Individual;informal care;informal caregiver;informal caregiving;innovation;Inpatients;insight;Institution;Insurance;Insurance Carriers;Interdisciplinary Study;Knowledge;Learning;Managed Care;Managed Care Programs;Measurement;Medicare;Methods;older adult;older patient;Older Population;Outcome;participant enrollment;Patient Care Management;Patient-Focused Outcomes;Patients;Pattern;Policy Maker;Policy Research;Population;Research;Resources;restraint;Role;Self Care;Self Management;Services;sex;social;Surveys;Testing;United States;uptake;Work

PROJECT_TITLE: The impact of Medicare managed care on older patients with dementia and their family caregivers.

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: PROJECT NARRATIVE – PROJECT 1 Approximately 15-25 million people worldwide are infected with HTLV-1 with a small percentage developing adult T-cell leukemia. The cancer is aggressive and there is currently no effective treatment. This project focuses on a novel viral gene encoded by the antisense strand of the HTLV-1 genome, termed hbz, and the proposed studies will provide a significant advance in our basic knowledge of the role of hbz in transformation and disease and will have significant implications for therapeutic targeting.

PROJECT_TERMS: Adult Precursor T Lymphoblastic Leukemia;Adult T-Cell Leukemia/Lymphoma;Animal Model;Animals;Attenuated;Binding;Binding Proteins;Biological Assay;Bone Diseases;Cancer Model;Cell Proliferation;Cell Survival;Cells;Cellular biology;chronic infection;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Data;design;Disease;Disease Progression;DNA Double Strand Break;effective therapy;experimental study;Foundations;Funding;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Human T-lymphotropic virus 1;Human T-lymphotropic virus 2;In Vitro;in vivo;Individual;Infection;insight;IRF1 gene;Knock-out;Knowledge;leukemia/lymphoma;leukemogenesis;Malignant - descriptor;Malignant Neoplasms;Mediating;Messenger RNA;metaplastic cell transformation;Modeling;Nervous System Disorder;Nitric Oxide Synthase;novel;Oncoproteins;Oryctolagus cuniculus;Osteolytic;Outcome;p65;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Play;prevent;Process;protein expression;Protein Interaction Mapping;Proteins;Proteomics;Repression;Retroviridae;RNA;Role;senescence;Signal Pathway;Signal Transduction;Structure;tax Genes;Taxes;therapeutic target;TOP1 gene;Transactivation;Transforming Growth Factor beta;Transgenic Mice;Translating;tumor;ubiquitin-protein ligase;vector;Viral;Viral Genes;Viral Vector;Virus Diseases;virus host interaction;Work

PROJECT_TITLE: Project 1: Role of HTLV-1 Hbz in Transformation and Disease


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: HERSHEY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: NARRATIVE Men and women infected with human immunodeficiency virus have higher rates of HPV16 infection, longer persistence of HPV16, increased incidence of head and neck cancer, poorer prognosis, as well as more recurrences after definitive therapy. The risk of HPV-associated oropharyngeal cancer are higher among HIV- infected patients in the HAART era compared to the general population. Generally, HPV infections are self- limiting, however, persistent HPV infection is a major risk to carcinogenic progression. Long intervals between initial infection and the development of cancer imply cofactors are involved. We hypothesize that HAART therapy is a cofactor increasing the cancer risk..

PI_NAMEs: MEYERS, CRAIG M (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Affect;AIDS diagnosis;Area;Biological Markers;Cancer Burden;cancer risk;carcinogenicity;Cessation of life;chemotherapy;Clinical;co-infection;cofactor;Coupled;Development;Disease-Free Survival;Epithelial Cells;Exhibits;General Population;Glycolysis;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;high risk;Highly Active Antiretroviral Therapy;HIV;HPV negative;HPV positive;HPV-negative head and neck cancer;Human;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;improved;In Vitro;Incidence;Individual;Infection;Life Cycle Stages;Life Expectancy;malignant mouth neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;men;Metabolic Pathway;Mitochondria;Modeling;Morbidity - disease rate;mortality risk;Natural History;oral cavity epithelium;oral HPV infection;oral HPV-positive head and neck cancers;oral tissue;Oropharyngeal;Patients;Persons;Pharyngeal structure;Positioning Attribute;premalignant;Prognosis;Radio;Recording of previous events;Recurrence;Respiration;response;Risk;Role;Sampling;Sampling Studies;scale up;Site;Testing;therapeutic target;Tissue Sample;Tobacco;trend;tumor progression;Woman

PROJECT_TITLE: Understanding the Role of HAART in the Progression of HPV-Associated Oral Cancer


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hematology;Lung;Orphan Drug;Rare Diseases;Sickle Cell Disease;Sleep Research

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE African Americans and Latino/Hispanic Americans have a higher risk of death from heart disease, and a disproportionally lower number of both minority groups are employed in the health professions and participate in clinical research. One approach to addressing these disparities is to increase the number of underrepresented minorities who pursue careers in the health professions. Thus, we will establish an intensive summer research education program to prepareand motivate underrepresented minority students to enroll in MD/PhD and PhD programs, building on the University of Pittsburgh’s track record in achieving success in such programs.

PI_NAMEs: JONASSAINT, CHARLES RICHARD (contact);OFORI-ACQUAH, SOLOMON FIIFI

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Address;African American population;American;Area;Asthma;Basic Science;Behavioral;Behavioral Research;Biology;Biomedical Research;Blood;Blood Vessels;Body System;Cardiology;cardiovascular health;career;career development;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Coagulation Process;Competence;Discipline;Disease;Disparity;Doctor of Philosophy;education research;Educational Curriculum;Educational workshop;Enrollment;Environment;Ethnic Population;experience;Exposure to;Faculty;Goals;graduate school;hands on research;Health;health disparity;Health Occupations;Health Sciences;Heart;Heart Diseases;heart imaging;Hematological Disease;Hematology;Hemolysis;high risk;Hispanic Americans;Housing;Immersion;improved;Infrastructure;Inherited;innovative technologies;Instruction;interest;Interview;Knowledge;Latino;Learning;Learning Skill;lectures;Lung;Medical;Medical center;medical schools;Medicine;member;Mentors;Methodology;Minority Groups;Mission;Molecular Biology;mortality risk;National Heart, Lung, and Blood Institute;next generation;novel therapeutic intervention;Oncology;Outcome;patient population;Patients;Pharmacology;Physicians;Process;programs;Pulmonary Hypertension;racial population;Recording of previous events;recruit;Regenerative Medicine;Research;Research Personnel;Research Project Grants;role model;Science;Scientist;Services;Sickle Cell Anemia;skills;Sleep;Sleep Disorders;Stroke;Students;success;summer research;Talents;Thalassemia;Thrombosis;Training;Training and Education;transfusion medicine;Translational Research;undergraduate research;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Universities;Vascular Diseases;Writing

PROJECT_TITLE: Pittsburgh Undergraduate Research Diversity Program (PURDIP)


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: PROJECT NARRATIVE – PROJECT 2 Adult T-cell leukemia/lymphoma (ATL), an aggressive leukemia that is associated with hypercalcemia and osteolytic bone lesions develops in 2-4% of HTLV-1 infected individuals. We will investigate new roles for two bone-acting factors, regulated by the HTLV-1 viral oncogene Hbz, in reprogramming the bone environment. These represent therapeutic opportunities to target the significant bone loss in ATL patients, as well as affect progression of ATL tumors which are often resistant to standard chemotherapy.

PI_NAMEs: VEIS, DEBORAH J (contact)

PROJECT_TERMS: Ablation;Active Sites;Adult;Adult T-Cell Leukemia/Lymphoma;Affect;analysis pipeline;Animals;antagonist;Biological Availability;Biological Models;Blood Cells;bone;bone cell;Bone Diseases;bone invasion;bone loss;Bone neoplasms;Bone Resorption;Cancer Model;Cell Communication;Cell Line;Cell surface;Cells;chemotherapy;Collaborations;CRISPR/Cas technology;cytokine;Data;Development;Environment;experience;Experimental Designs;experimental study;Extracellular Matrix;Funding;Growth Factor;heparanase;Heparitin Sulfate;HTLV-1 Infection;Human;Human T-lymphotropic virus 1;humanized mouse;Hypercalcemia;Immune response;Immune system;Immunodeficient Mouse;Implant;implantation;In Vitro;in vivo;in vivo Model;Individual;Infection;Injections;intraperitoneal;Lesion;leukemia;Lymphoma cell;Lymphoproliferative Disorders;Lytic Metastatic Lesion;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Marrow;Mediating;Mediator;Modeling;mouse model;Multiple Myeloma;Mus;mutant;Oncogenes;Osteoblasts;Osteoclasts;Osteolytic;paracrine;Pathogenesis;Pathologic;patient derived xenograft model;Patients;Persons;pharmacologic;Phenotype;Play;pleiotropism;Process;Productivity;programs;Protein Isoforms;Proteins;Recurrence;Reporting;Resistance;Retroviridae;Role;success;T-Lymphocyte;Taxes;Techniques;Therapeutic;three dimensional cell culture;TNFSF11 gene;Transgenic Mice;Transplantation;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor-Derived;tumorigenesis;tumorigenic;Umbilical Cord Blood;vector;Viral;Viral Oncogene;Viral Vector;WNT Signaling Pathway;Work

PROJECT_TITLE: Project 2: Effect of HTLV-1 Viral Oncogenes on the Bone Microenvironment during tumor growth and progression in ATL


ADMINISTERING_IC: DK

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Diabetes;Gene Therapy;Genetics;Regenerative Medicine;Wound Healing and Care

ORG_CITY: Newark

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Diabetic foot ulcers (DFUs) and other chronic wounds are enormously costly worldwide health concerns that often necessitate amputation and are associated with a significantly increased risk of death. The purpose of this project is to develop gene-containing biomaterials that help control the behavior of critical cells within DFUs by harnessing collagen remodeling to stimulate reliably localized expression of key healing factors including growth factors and immunomodulatory cytokines. The proposed studies will identify design principles and mechanisms associated with these biomaterials in the DFU environment, which will ultimately allow their use not only for improved cutaneous repair, but also for multiple other applications in regenerative medicine.

PI_NAMEs: KIICK, KRISTI L;MARGOLIS, DAVID ;SPILLER, KARA LORRAINE;SULLIVAN, MILLICENT O (contact)

PROJECT_TERMS: acute wound;Amputation;Behavior;Behavior Control;Binding;Biocompatible Materials;Biological Assay;Cells;Cessation of life;Chromosome Mapping;Chronic;chronic wound;Climate;Clinical;Collagen;Collagen Fibril;Collagen Gene;Complement;Complex;cost;Coupled;cytokine;Cytokine Gene;Data;design;diabetic;Diabetic Foot Ulcer;diabetic ulcer;DNA;DNA Integration;Dose;economic impact;Engineering;Environment;Equilibrium;Etiology;Exudate;Fibroblasts;Friends;Gene Delivery;Gene Expression;Gene Modified;gene product;gene therapy;Gene Transfer;Genes;Growth Factor;Growth Factor Gene;Growth Factor Overexpression;Half-Life;healing;Health;Human;IL4 gene;Immunology;immunoregulation;improved;in vivo;Incidence;Inflammatory;inflammatory milieu;innovation;insight;Interleukin-10;Investigation;Leg;Link;Macrophage;Mediating;Membrane;Modality;Modeling;Modification;mortality risk;Mus;Outcome;Patient-Focused Outcomes;Peptide Hydrolases;peptidomimetics;Phenotype;Platelet-Derived Growth Factor;pre-clinical;Production;Property;Regenerative Medicine;regenerative therapy;repaired;Research Project Grants;Role;Safety;scaffold;Signal Transduction;Skin repair;Testing;Therapeutic;therapeutic gene;therapeutic protein;Time;Translating;Translations;Variant;wound;wound bed;wound care;wound dressing;wound environment;wound healing;wound treatment

PROJECT_TITLE: COATs: Collagen-mimetic peptide and therapeutic gene-modified collagens for cell-mediated healing of diabetic foot ulcers

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: PROJECT NARRATIVE- PROJECT 3 This project investigates the role of a cellular protein (CTCF) that binds to a specific site (CTCF-BS) in the integrated HTLV-1 DNA as well as many sites in the lymphocyte DNA; this interaction is known to introduce loops into DNA and affect expression of genes. We will investigate whether the CTCF-BS affects the ability of HTLV-1 to replicate, establish latency, a state in which the viral DNA is present in the cell but it is not copied into RNA and proteins, and cause leukemia and lymphoma in immunodeficient mice. These studies will elucidate the mechanism of action of CTCF in regulating HTLV-1 replication and transformation.

PI_NAMEs: RATNER, LEE  (contact)

PROJECT_TERMS: Adult T-Cell Leukemia/Lymphoma;Affect;Animals;Binding;Binding Proteins;Binding Sites;Biology;Biometry;Cancer Model;CCCTC-binding factor;CD3 Antigens;CD34 gene;CD4 Positive T Lymphocytes;Cell Line;Cell Proliferation;Cells;Characteristics;Chromatin;Chromatin Conformation Capture and Sequencing;Chromatin Loop;chromatin modification;Clinical;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complementary DNA;CRISPR/Cas technology;Deterioration;Development;Disease;Disease Progression;DNA;DNA Methylation;DNA Modification Process;DNA Viruses;Elements;Enhancers;Epigenetic Process;epigenetic regulation;epigenomics;experimental study;Frequencies;Funding;Gene Expression;Generations;Genetic Transcription;Genome;Goals;Herpesviridae;Histologic;Histology;histone methylation;histone modification;Histones;HIV;Human;Human Genome;human model;Human T-lymphotropic virus 1;humanized mouse;Immune response;immunodeficiency;Immunodeficient Mouse;in vivo imaging system;Infection;insight;integration site;Jurkat Cells;leukemia;leukemia/lymphoma;Leukocytes;LIM Domain;LIM Domain Protein;Lymphocyte;Lymphocyte Activation;Lymphoid Cell;Lymphoma;Malignant - descriptor;Malignant Neoplasms;Measures;Mediating;Messenger RNA;Methylation;Modeling;Modification;Molecular;mouse model;Mus;Mutate;Mutation;nuclease;Oncogenes;Pathogenesis;Pathologic;Pattern;precursor cell;preference;Productivity;Proliferating;Protein Binding Domain;Proteins;Proviruses;Publications;reactivation from latency;reconstitution;Refractory;Regulation;Retroviridae;RNA;RNA Splicing;Role;Sample Size;Site;Specificity;Stains;T-Lymphocyte;Taxes;Time;tumor;tumorigenesis;Umbilical Cord Blood;Viral;viral DNA;Viral Proteins;Viral Vector;Virus;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Project 3: Role of CTCF in HTLV-1 Replication and Transformation


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The rate of ribosome synthesis is proportional to cell growth and proliferation rates. RNA polymerase I makes the ribosomal RNA and this step is rate-limiting for ribosome synthesis. This project will reveal unique properties of RNA polymerase I that may be targeted therapeutically to control cancer cell proliferation.

PI_NAMEs: SCHNEIDER, DAVID ALAN (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Affect;anti-cancer;Biochemical;Biology;Biophysics;Cancer Control;cell growth;Cell Proliferation;Cell Survival;Chemotherapy-Oncologic Procedure;Development;DNA Polymerase I;DNA Polymerase II;DNA Polymerase III;DNA-Directed RNA Polymerase;Enzymes;Eukaryotic Cell;Foundations;Future;Gene Expression;Genetic;Genetic Transcription;Genomics;Goals;inhibitor;Messenger RNA;Methodology;novel;Nuclear;Prokaryotic Cells;Property;Ribosomal DNA;Ribosomal RNA;Ribosomes;RNA;RNA chemical synthesis;RNA Polymerase I;RNA, Ribosomal, 5S;Role;targeted treatment;Therapeutic;therapeutic target;transcription factor;Transcriptional Regulation;Transfer RNA

PROJECT_TITLE: UNDERSTANDING THE ROLES OF RNA POLYMERASE I IN TRANSCRIPTION AND BEYOND

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

ORG_STATE: NY

PHR: Project Narrative Acetylcholine (ACh) and dopamine (DA) are co-regulated in the striatum during salient events, but it is unclear whether they are regulated independently from each other, whether they mutually regulate each other, and whether their temporal co-incidence is important for cognitive flexibility. Studying striatal co-regulation of DA and ACh during flexible learning will give important insights in the role of both neuromodulators for learning and will aid our understanding of brain disorders with altered DA-ACh function including Schizophrenia and Parkinson disorder.

PI_NAMEs: KELLENDONK, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Acetylcholine;acetylcholine transporter;Acute;Affect;Animals;Attenuated;Behavior;behavior measurement;Behavioral;Brain;Brain Diseases;cholinergic;clinically relevant;Code;Cognitive;Computer Models;Corpus striatum structure;Cues;Data;Disease;Dopamine;Dopamine D2 Receptor;dopaminergic neuron;DRD2 gene;Educational process of instructing;Electrophysiology (science);Event;flexibility;Functional disorder;gain of function;Generations;Impaired cognition;Impairment;in vivo;insight;Interneuron function;Interneurons;learned behavior;Learning;Length;Lesion;Measures;Mediating;Mental disorders;Mus;Neuromodulator;Neurons;Neurotransmitters;nonhuman primate;novel therapeutics;optogenetics;Outcome;Oxidopamine;Parkinson Disease;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Phase;Physiology;Play;Primates;Regulation;response;Reversal Learning;Rewards;Role;Schizophrenia;sensor;Signal Transduction;Slice;Stimulus;System;temporal measurement;Testing;Thalamic structure;Therapeutic;Time;tool;Up-Regulation

PROJECT_TITLE: Co-Regulation of Striatal Dopamine and Acetylcholine During Flexible Learning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


PROJECT_TERMS: Adult T-Cell Leukemia/Lymphoma;Animals;Authorship;Biocompatible Materials;Biometry;Biostatistics Core;Budgets;Cancer Model;cell immortalization;Clinical;Collaborations;computerized data processing;Data;Data Set;data sharing;data standards;Databases;Dependence;design;Diagnosis;Disputes;Effectiveness;Ensure;Evaluation;Experimental Designs;Fostering;Glean;Goals;Grant;HTLV-1 Infection;Human T-lymphotropic virus 1;Information Dissemination;Institution;inter-institutional;Investigation;Knowledge;Laboratories;Leadership;leukemia;leukemia/lymphoma;meetings;member;model design;Modeling;Monitor;Occupational activity of managing finances;Ohio;operation;Persons;preservation;Procedures;Program Effectiveness;Program Efficiency;Program Research Project Grants;programs;quality assurance;Reagent;Research;Research Personnel;Research Project Grants;Resource Allocation;Retroviridae;Retrovirology;Scientist;Secure;Services;Statistical Data Interpretation;statistics;Structure;symposium;T-Lymphocyte;Telephone;Time;tissue culture;Universities;Viral;Washington;Work

PROJECT_TITLE: Core A: Administration and Biostatistics


NIH_SPENDING_CATS: Cancer;Eye Disease and Disorders of Vision;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Tumor dormancy is a process whereby cancer cells enter an inactive state that enables them to survive environmental insults. This application aims to provide insight into tumor cell dormancy in uveal melanoma and compare to mechanisms that allow uveal melanoma cells to survive therapeutic attack at the metastatic site. Ultimately, our goal is to guide the development of more effective therapeutic strategies for uveal melanoma patients.

PI_NAMEs: AGUIRRE-GHISO, JULIO A.;APLIN, ANDREW ERIC (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Adjuvant;advanced disease;Aftercare;antagonist;Biology;cancer cell;cancer type;CDK4 gene;Cell Cycle Progression;Cell Cycle Regulation;Cell Survival;Cells;Clinical;Collaborations;Combined Modality Therapy;Complement;Complication;cyclin-dependent kinase inhibitor 1B;Data;design;Development;Disease;Distant;Drug Combinations;Drug resistance;Drug Tolerance;effective therapy;Epigenetic Process;ERBB2 gene;Estrogen receptor positive;Family;FDA approved;Future;gain of function;Genes;GNAQ gene;Goals;Growth;guanine nucleotide binding protein;Heterogeneity;Human;Immunotherapy;In Vitro;inducible gene expression;inhibitor;inhibitor therapy;innovation;insight;Institution;knock-down;Label;Link;Liver;liver development;loss of function;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;Metastatic Melanoma;Metastatic Neoplasm to the Liver;Micrometastasis;Modeling;Molecular Profiling;mutant;Mutation;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Ocular Melanoma;Oncogenic;Orphan;Oxidative Phosphorylation;Patients;pre-clinical;preferentially expressed antigen in melanoma;prevent;Primary Neoplasm;Process;prognosis biomarker;Publishing;receptor;Recurrence;Reporter;Reporting;Research;Residual Neoplasm;Residual state;Resistance;response;Retinoic Acid Receptor;Sampling;Schedule;Signal Pathway;Signal Transduction;Site;spheroids;synergism;targeted agent;targeted treatment;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;transcriptomics;Transforming Growth Factor beta;treatment response;tumor;tumor initiation;Up-Regulation;Uveal Melanoma

PROJECT_TITLE: Mechanisms of uveal melanoma dormancy and targeted therapy tolerance

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Infectious Diseases;Rare Diseases

PHR: PROJECT NARRATIVE – CORE 1 The Viral Vector Core will provide custom high quality lentiviral or retroviral vector particles to PPG labs for overexpression or reduced expression of host, viral, or novel function genes. Reduced expression vectors will deliver either shRNA or CRISPR/Cas9 to cells. Finally, a novel lentiviral CRISPR/Cas9 vector will be developed to limit Cas9 expression spatially and temporally.

PI_NAMEs: YODER, KRISTINE E (contact)

PROJECT_TERMS: Binding;Biological Assay;Cancer Model;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Consult;cost;Coupled;CRISPR/Cas technology;Custom;delivery vehicle;design;DNA;Elementary Particles;Engineering;Enzyme-Linked Immunosorbent Assay;expression vector;Feline Immunodeficiency Virus;fusion gene;Gene Expression;gene function;Genes;Genetic Engineering;genetic manipulation;Genetic Recombination;Genetic Transcription;Genome;genome editing;Guide RNA;HIV-1;homologous recombination;Human T-lymphotropic virus 1;hygromycin A;Individual;Initiator Codon;Integrase;interest;Laboratories;Leadership;Lentivirus Vector;Luciferases;Methodology;Methods;Modification;Murine leukemia virus;mutant;Mutation;Neomycin;novel;overexpression;particle;Pathogenicity;Phosphorylation;Point Mutation;prevent;promoter;Proteomics;prototype;Proviruses;Puromycin;Reagent;Recommendation;repaired;Reproducibility;Research Personnel;Resources;Response Elements;Retroviral Vector;Retroviridae;RNA Binding;RNA-Directed DNA Polymerase;selective expression;Services;short hairpin RNA delivery;Silent Mutation;skills;small hairpin RNA;Spumavirus;success;Taxes;Time;tool;Transfection;Transgenes;Variant;vector;vector control;Vesicular stomatitis Indiana virus;Viral;Viral Genome;Viral Vector;Visual;Work

PROJECT_TITLE: Core 1: Viral Vector Core


ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Obesity is one of the most common metabolic disorders in the world and the leading cause of Type 2 Diabetes. Our study aims to understand how the regulation of a microRNA, a small non-coding RNA, from the microvasculature regulates angiogenesis in adipose tissues and whether there is a correlation between improved angiogenesis and adipocyte function and obesity-induced insulin resistance. The results from our studies may have important translational implications and provide a new understanding for adipose tissue dysfunction in obesity induced insulin resistance.

PI_NAMEs: ICLI, BASAK  (contact)

PROGRAM_OFFICER_NAME: GALIS, ZORINA S

PROJECT_TERMS: 3' Untranslated Regions;3T3-L1 Cells;Ablation;Acceleration;Adipocytes;Adipose tissue;Age;angiogenesis;Angiogenesis Inhibition;Angiogenesis Inhibitors;Animal Model;Binding;Biological Assay;Brown Fat;cell growth;cell motility;Cell Proliferation;Coculture Techniques;Code;Development;diabetic;Diet;diet-induced obesity;disorder risk;Endothelial Cells;endothelial dysfunction;Energy Metabolism;Excision;Fatty acid glycerol esters;Functional disorder;Gene Expression;Genes;glucose tolerance;Growth;Growth Factor;Harvest;High Fat Diet;Homeobox;Hormones;Human;Immunohistochemistry;Impairment;improved;in vivo;inhibitor;insight;Insulin Resistance;insulin sensitivity;Intravenous;knock-down;Length;locked nucleic acid;MAP3K1 gene;Measures;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;MicroRNAs;miRNA expression profiling;Molecular;Mus;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Nucleotides;Nutrient;Obese Mice;Obesity;obesity development;Organ;Organoids;overexpression;Patients;PECAM1 gene;Phenocopy;Phosphotransferases;Plasma;Play;programs;Proteins;Regulation;response;Role;Sampling;Signal Pathway;Signal Transduction;Skin;Small Interfering RNA;Stains;Stimulus;subcutaneous;Testing;Therapeutic Intervention;Thermogenesis;Tissues;Transcript;transcriptome sequencing;Untranslated RNA;Vascular Endothelial Growth Factors;Vascularization;Waste Products;Western Blotting;Zinc deficiency;Zinc Fingers

PROJECT_TITLE: MiR-409-3p Regulates Angiogensis, Brown Fat Adiposity and Insulin Resistance

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Narrative Adolescents in residential substance use treatment have high risk of relapse after discharge, but it is extremely difficult to engage these adolescents and their parents in continuing care. This study aims to improve the outcomes of adolescents following discharge from residential substance use treatment by offering their parents a novel technology-assisted intervention. Technology-assisted interventions have the potential for marked public health impact by extending the reach, duration, and scalability of evidence-based care.

PI_NAMEs: BECKER, SARA  (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;adolescent binge drinking;adolescent substance use;Behavioral;binge drinking;Caring;Child Rearing;Clinical Trials;Communication;computer program;computerized;Controlled Environment;Data;design;Development;Distal;Drug usage;Effectiveness;effectiveness evaluation;Evaluation;evidence base;Exhibits;experience;externalizing behavior;Family;follow up assessment;Follow-Up Studies;Funding;Goals;high risk;high risk sexual behavior;improved;improved outcome;in vivo;Intervention;Legal;Measurement;Measures;Mediating;Mediator;Methods;Mind;Modeling;Monitor;Motivation;National Institute of Drug Abuse;new technology;Notification;Outcome;parent-adolescent communication;parental monitoring;parenting intervention;Parents;Patient Self-Report;pilot trial;Problem behavior;Process;psychologic;Public Health;Randomized;Recommendation;Relapse;relapse risk;Research;Residential Treatment;Risk;Schools;skills;substance misuse;substance use;Substance Use Disorder;substance use treatment;Technology;telehealth;Testing;Time;treatment as usual;treatment center;Truancy;Underserved Population;Urine;Vocation;Youth

PROJECT_TITLE: Improving Outcomes of Adolescents in Residential Substance use Treatment via a Technology-Assisted Parenting Intervention

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Cancer;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: PROJECT NARRATIVE – CORE 2 The overall theme of the PPG is to analyze how infection with HTLV-1 induces proliferation of CD4 T cells, what cellular events occur during transformation and how the tumor cells interact with their microenvironment. After acute infection, HTLV-1 persists in the organism, eventually leading to oligoclonal and finally monoclonal proliferation and transformation of CD4+ T cells. Core 2 supports the Program Project Grant through the rabbit model, mouse xenograft models, mouse model with a human immune system (HIS mice).

PI_NAMEs: NIEWIESK, STEFAN  (contact)

PROJECT_TERMS: Acute;acute infection;Adhesions;Adult T-Cell Leukemia/Lymphoma;American;Anatomy;Animal Model;animal model development;Animals;Biological Sciences;bone;Bone remodeling;Cancer Model;CD4 Positive T Lymphocytes;Cell Communication;Cell Line;Cells;Certification;Cessation of life;Chronic;chronic infection;Clinical;clinical development;college;Crossbreeding;cytokine;Data;Development;Diagnosis;Disease;Equipment;European;Evaluation;Event;Funding;Genes;Genome;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Histologic;HTLV-1 Infection;Human;Human T-lymphotropic virus 1;humanized mouse;IL3 Gene;immune reconstitution;Immune response;Immune system;immunodeficiency;Implant;in vivo;Individual;Infection;Interleukin-15;Intravenous;Invaded;Investigation;Laboratory Animal Medicine;leukemia/lymphoma;Leukemic Cell;Lymphocyte;Lymphocyte Activation;Lymphoma cell;Lymphoproliferative Disorders;Macrophage Colony-Stimulating Factor;Mediating;Microbiology;Modeling;Molecular;Molecular Cloning;mouse model;Mucous Membrane;Mus;neoplastic cell;NOD/SCID mouse;Organism;Oryctolagus cuniculus;Osteolysis;Pathologic;Pathology;Patients;Phagocytosis;Phase;Phenotype;Principal Investigator;Program Research Project Grants;Proliferating;Property;Proteins;Protocols documentation;PTPNS1 gene;Reporting;Research;Research Personnel;Retroviridae;RNA;Role;Route;sample collection;Services;Standardization;stem cells;Study models;T-Cell Leukemia;Testing;Thrombopoietin;Time;transmission process;tumor;tumorigenesis;Umbilical cord structure;Veterinary Pathology;Viral Proteins;Virus;Virus Activation;Virus Integration;Virus Latency;Virus Replication;Xenograft Model

PROJECT_TITLE: Core 2: Animal Models


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative We use behavioral and neuroimaging measurements to extend our longitudinal investigation of children from the UC Davis MIND Institute Autism Phenome Project cohort into adolescence, with a focus on examining cognition, social functioning, and the emergence of depression in individuals with three phenotypes of intellectual functioning (IQ) from early childhood to adolescence—one with persistent intellectual disability (ID) (P-Low); one with persistently average or better IQs (P-High); and one with IQs improving from the ID to the average or better range (+CHG). We predict that P-Low will exhibit strengths in episodic memory, and low levels of depression, although we investigate whether this is a result of under-reporting; that P-High, while cognitively able, will experience the highest levels of depression; and that +CHG will show strongest cognitive and social development without some of the liabilities experienced by P-High.

PI_NAMEs: SOLOMON, MARJORIE  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent with autism spectrum disorder;Adult;Age;Amygdaloid structure;Anxiety;Anxiety Disorders;autism spectrum disorder;autistic children;Awareness;Behavior;behavior prediction;Behavioral;Brain imaging;Characteristics;Child;child depression;Cognition;Cognitive;cognitive ability;cognitive control;cognitive development;cohort;Complex;Corpus striatum structure;Coupled;Depressed mood;depressive symptoms;Development;Disease;early childhood;Early identification;Emotional;Emotions;Episodic memory;Exhibits;experience;flexibility;Functional Magnetic Resonance Imaging;Grant;Heterogeneity;Hippocampus;improved;Individual;Intellectual functioning disability;Interview;Investigation;Knowledge;Longitudinal Studies;Measurement;Memory;Mental Depression;Mental disorders;middle childhood;Modeling;Motivation;National Institute of Mental Health;neural;neural circuit;neuroimaging;Outcome;Parents;Performance;phenome;Phenotype;Pilot Projects;precision medicine;predictive modeling;Psychopathology;Questionnaires;Reporting;Rest;social;Social Development;Social Functioning;social relationships;Strategic Planning;Testing;therapy development;Time

PROJECT_TITLE: Neural and behavioral predictors of cognitive development and internalizing problems in adolescents with autism spectrum disorder

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Program Narrative Neurosteroids and cholesterol are important signaling molecules that modulate the function of integral membrane proteins. The proposed research will define the specific binding sites for neurosteroids on various forms of their major target protein, the GABA type A receptor and for cholesterol on lipid scramblases and lysosomal signaling proteins. The work will identify site-specific agonists and antagonists for the sterol binding sites and provide new insights into the biological role of neurosteroids and cholesterol as allosteric modulators of protein function.

PI_NAMEs: EVERS, ALEX S. (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Affinity;Agonist;Amino Acid Substitution;Aminobutyric Acids;Anesthetics;antagonist;anti-depressive agents;Behavioral;Binding;Binding Sites;Biological;Biological Assay;Cholesterol;cholesterol analog;Cryoelectron Microscopy;Dependence;Event;Fluorescence;FRAP1 gene;gamma-Aminobutyric Acid;Goals;insight;Integral Membrane Protein;Laboratory Study;Ligands;Lipids;Mass Spectrum Analysis;Measures;Mediating;Membrane Proteins;Methods;Molecular Conformation;monomer;nervous system development;neuronal excitability;Neuroprotective Agents;neurosteroids;novel;programs;Protein Chemistry;protein expression;protein function;protein phosphatase inhibitor-2;Proteins;Reader;receptor;Research;Resolution;Role;screening;sedative;Signaling Molecule;Signaling Protein;Site;small molecule;Specificity;Sterols;Structure;Synapses;Techniques;Therapeutic;tool;Work

PROJECT_TITLE: Neurosteroid and Cholesterol Binding to Integral Membrane Proteins

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Infectious Diseases;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARATIVE The goal of this proposal is to develop and validate a new point-of-care test for early diagnosis and screening of talaromycosis, a leading cause of AIDS-related deaths in Southeast Asia. We will also assess the costs and opinions from stakeholders to inform policy development. The test may allow doctors to begin treatment earlier which can prevent disease from developing or from progressing further into fulminant stage, thus improving patient outcomes and reducing mortality.

PI_NAMEs: CHILKOTI, ASHUTOSH ;LE, THUY  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Affect;Antifungal Therapy;Asia;bench to bedside;Biological Markers;Blood;Body Fluids;burden of illness;Caring;Cells;Cessation of life;China;Clinic;Clinical;cohort;commercialization;Communities;Complex;cost;Cost Analysis;cost effective;cost effectiveness;Costs and Benefits;Country;Cryptococcosis;Data;Detection;detection limit;detector;Development;Diagnosis;Diagnostic;Diagnostic Procedure;diagnostic tool;Discipline;Disease;Dose;Early Diagnosis;early screening;Early treatment;Engineering;Enzyme Immunoassay;Failure;forging;fungus;Goals;Guidelines;Health system;Histology;HIV;Hospitalization;Human;Image;Immunoassay;Immunocompromised Host;implementation facilitation;Implementation readiness;improved;Incubated;Individual;individual patient;Infection;International;Laboratories;mannoproteins;Medical;Microfluidics;Microscopy;Modeling;mortality;multidisciplinary;Mycoses;novel;Organ;Outpatients;Patient-Focused Outcomes;Patients;Performance;Persons;point of care;point of care testing;Policies;Policy Developments;Policy Maker;Policy Making;polyclonal antibody;Polymers;Population;pre-clinical;prevent;Printing;prognostic;prospective;Proteins;Provider;Public Health;Rapid diagnostics;rapid test;Reagent;Reference Standards;response;Risk;risk prediction;Role;Running;Sampling;Science;screening;Screening procedure;screening program;Serum;skin lesion;Southeastern Asia;Specificity;Speed;stakeholder perspectives;Talaromyces;Technology;Testing;Thailand;Time;Translating;Translations;Tuberculosis;Urine;Validation;Vietnam

PROJECT_TITLE: Development, Clinical Validation, and Readiness for Implementation of a Novel Mp1p D4 Poin Diagnosis of Talaromycosist of Care Test for Rapid

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-H(02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Burden of Illness;Cerebrovascular;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CINCINNATI

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE Emerging studies show the existence of a black-white disparity in the incidence and prevalence of vascular cognitive impairment (VCI) as well as other Alzheimer's disease and related dementias (ADRDs). Thus, it is important to identify factors contributing to this disparity. This proposal focuses on vascular and genetic risk factors associated with abnormalities in the small blood vessels in the brain. We will examine the prevalence of these abnormalities in black and white adults with stroke or transient ischemic attack and whether these risk factors contribute to the black-white disparity in VCI and ADRDs.

PI_NAMEs: HYACINTH, HYACINTH IDU (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: adjudication;Adult;Alzheimer's Disease;Alzheimer's disease related dementia;American;analysis pipeline;Anatomy;Ancillary Study;black men;Black Populations;black women;black/white disparity;Blood Vessels;Brain;brain volume;burden of illness;carrier status;cerebral microbleeds;Cerebral small vessel disease;Cerebrovascular system;cognitive reserve;cognitive testing;cohort;Consensus;Dementia;dementia risk;design;detector;Development;disorder risk;Disparity;District of Columbia;Epidemiology;Evaluation;Event;experience;Genetic;Genetic Carriers;Genetic Risk;genetic risk factor;Genotype;geographic difference;Geography;Goals;gray matter;Growth;High Prevalence;high risk population;Hispanic Populations;Home;Hospitals;human old age (65+);Hypertension;Image;Impaired cognition;Incidence;Individual;International;Lesion;Magnetic Resonance Imaging;Measures;Mediator;men;Methodology;Minority Groups;MRI Scans;neuroimaging;Not Hispanic or Latino;Older Population;parent grant;Participant;Pattern;Phenotype;Population;Population Heterogeneity;post stroke;Prevalence;Prevention strategy;Prospective, cohort study;Race;racial difference;racial disparity;Recovery;Reporting;Research;Resources;Retrieval;Risk;Risk Factors;risk variant;Role;Severities;socioeconomics;Stroke;Stroke Belt;stroke incidence;stroke risk;study population;Telephone;Testing;Time;Transient Ischemic Attack;treatment strategy;TREM2 gene;US State;Variant;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;vascular risk factor;White Matter Hyperintensity;Woman

PROJECT_TITLE: Cerebral small vessel disease burden and racial disparity in vascular cognitive impairment and Alzheimer’s disease and its related dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-K(02)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: FAIRBANKS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ALASKA FAIRBANKS

ORG_STATE: AK

PHR: PROJECT NARRATIVE Vitamin D deficiency affects over one billion people world wide and is linked to a myriad of health disorders, including neurodegenerative diseases, cancers, diabetes, and impaired immune function. Sunlight exposure converts a pro-hormone to the active vitamin D hormone in the skin, and therefore populations living at higher latitudes are more at risk. Using a dog model of the circumpolar north, this project will look at the effects of age, and dietary intervention on vitamin D status and its relationship with markers of brain aging, and metabolic syndrome.

PI_NAMEs: DUNLAP, KRIYA L (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Adoption;Affect;Age;age effect;Aging;aging brain;Alaska;Alaska Native;Alaskan;Animal Model;Arctic Regions;Biochemical Pathway;Biological Markers;Biomedical Research;Brain;brain health;canine model;Canis familiaris;Child;Chronology;Coin;Consensus;Consumption;Custom;Data;Dementia;Diabetes Mellitus;Diet;Dietary intake;Dietary Intervention;Dietary Supplementation;Disease;Diurnal Rhythm;Eating;Economics;Elderly;Exercise;Exhibits;experience;Fishes;Food;Glucose Transporter;GLUT 4 protein;Goals;gray matter;gut health;Health;healthy aging;high risk;Hormones;Human;immune function;Impaired cognition;Impairment;improved;Indigenous;inflammatory marker;Insulin;Insulin Resistance;insulin signaling;Intake;Intervention Studies;Inuits;Knowledge;Laboratory Animals;life span;Life Style;Ligands;Link;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Metabolic;Metabolic Diseases;Metabolic Marker;metabolic rate;Metabolic syndrome;Modeling;Morphology;Neurodegenerative Disorders;North America;Nutrient;Nutritional;Outcome;Oxidative Stress;Peripheral Blood Mononuclear Cell;Persons;Play;Polyunsaturated Fatty Acids;Population;Prevalence;prevent;Process;Production;prohormone;Public Health;Recommendation;Reporting;Research;response;Rickets;Risk;Risk Factors;Role;Rural;Salmon;Sample Size;Seasonal Variations;Sentinel;Serum;Skin;Sledding;Societies;Source;Sun Exposure;Sunlight;Tissues;transcription factor;trend;UV Radiation Exposure;Vitamin D;Vitamin D Deficiency;Vitamin D3 Receptor;western diet;white matter;Yup'ik

PROJECT_TITLE: Vitamin D and Healthy Aging: Establishing the Sled Dog Sentinel for the Circumpolar North

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ATHENS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Heterotrophic protozoans play critical roles in aquatic environments through their consumption of planktonic autotrophs that they capture and consume via an enigmatic endocytic structure known as the cytostome/cytopharynx complex (SPC). Intriguingly, the kinetoplastid parasite Trypanosoma cruzi also retains this ancestral organelle and uses it to endocytose extracellular host material in a manner analogous to its free- living bodonid relatives. Very little is known about how the SPC is formed or functions and this proposal seeks to continue our analysis of this feeding structure and characterize the molecular machinery responsible for cargo capture at the surface, signal transmission to initiate endocytosis and ultimately trafficking along the SPC for lysosomal digestion.

PI_NAMEs: ETHERIDGE, RONALD DREW (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Actin-Binding Protein;Actins;Active Biological Transport;Amino Acids;Area;Binding;Binding Proteins;Biogenesis;Biology;Carbon;Cell membrane;Cell Survival;Cells;Cholesterol;Cilia;Complement;Complex;Consumption;Curiosities;Cytoplasm;Digestion;Dimensions;Eating;Ecosystem;Endocytosis;Environment;Eukaryota;extracellular;Family;feeding;Filament;Flagella;Food;Food Webs;glycosylation;Goals;Health;Human;In Vitro;induced pluripotent stem cell;inhibitor;insight;Integral Membrane Protein;Knock-out;Life;Light;Lysosomes;Mass Spectrum Analysis;Mastigophora;Mechanics;Mediating;Membrane Microdomains;Methodology;Methods;microbial;model organism;Molecular;Molecular Analysis;Motor;Myosin ATPase;Nutrient;Oral;Organelles;Organism;overexpression;palmitoylation;Parasites;Parasitic Diseases;parasitism;Phosphotransferases;Photons;Plants;Play;polymerization;Polymers;Positioning Attribute;Predatory Behavior;Process;Protein Isoforms;Proteins;Protozoa;Publishing;receptor;Receptor Protein-Tyrosine Kinases;Receptor Signaling;recruit;Reporting;Role;Route;Signal Pathway;Signal Transduction;Signaling Molecule;Site-Directed Mutagenesis;Source;Structure;Surface;Techniques;tool;trafficking;transmission process;Trypanosoma cruzi;Tubular formation;Vesicle;Work

PROJECT_TITLE: Elucidating the Mechanistic Basis for Phagotrophy in the Protozoan Trypansoma cruzi

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Rare Diseases

ORG_CITY: BERKELEY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Kaposi's sarcoma-associated herpesvirus (KSHV) is an emerging Group 1 pathogen and the major cause of cancers in untreated AIDS patients. Successful KSHV replication requires it to control gene expression in the infected cell, which is broadly achieved via widespread destruction of protein coding RNAs. This grant is focused on revealing a how the viral nuclease responsible for this process alters RNA fate, and how the infected cell senses and responds to message depletion.

PI_NAMEs: GLAUNSINGER, BRITT A (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Africa;AIDS related cancer;Area;Biology;Cancer Etiology;cell type;Cells;Cellular Stress;Chromatin;Code;Cytoplasm;Data;Disease;Disease Progression;Disparate;Distal;endonuclease;Environment;Etiology;Feedback;Funding;gammaherpesvirus;Gene Expression;Gene Expression Regulation;gene repression;Genetic Transcription;Grant;Herpesviridae;Herpesviridae Infections;HIV;HIV Infections;Human Herpesvirus 8;Immune Evasion;Immune system;Immunosuppression;in vivo;Infection;Kaposi Sarcoma;Life Cycle Stages;Link;Lytic;lytic replication;Malignant Neoplasms;Mammalian Cell;Messenger RNA;Modification;mouse model;novel;Nuclear;nuclease;pathogen;Pathway interactions;Patients;Perception;Phase;Play;Polymerase;Population;Predisposition;preservation;Process;Proliferating;protein protein interaction;protein transport;Proteins;Reader;Regulation;RNA;RNA Decay;RNA Degradation;RNA Polymerase II;RNA Processing;RNA Sequences;RNA Stability;RNA-Binding Proteins;Role;Shapes;Specificity;stem;Stress;Structure;targeted nucleases;Testing;Viral;Viral Genome;Viral Proteins;Virus;Work

PROJECT_TITLE: Disruption of Cellular RNA Processing by Kaposi's Sarcoma-Associated Herpesvirus

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: We aim to harmonize and aggregate trans-national cohorts of Alzheimer’s Disease Neuroimaging Initiative for improving the early detection of Alzheimer’s disease and related dementias. In the process, we will gain valuable insight into the underlying mechanisms driving the pathogenesis of these disabling disorders, thereby paving the way for better clinical tools, so that future disease-modifying therapy can be allocated more efficiently to patients.

PI_NAMEs: CHOUPAN, JEIRAN ;SHEIKH-BAHAEI, NASIM ;VARGHESE, BINO ABEL (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Address;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;American;Amyloid;apolipoprotein E-4;Automobile Driving;Biological;Biological Markers;biomarker development;biomarker identification;Blood;Blood Vessels;Brain Pathology;Categories;Classification;Clinical;clinical biomarkers;Clinical Data;clinical phenotype;cohort;combat;Computer software;Data;Data Aggregation;data harmonization;data modalities;data portal;Data Set;data sharing;deep learning;Development;Diagnosis;Diagnostic;Disabling;Disease;diverse data;Early Diagnosis;Ethnic Population;Funding;Future;Genotype;Goals;Health Status;Hemorrhage;Heterogeneity;Image;improved;Individual;innovation;insight;interest;International;Japanese;Label;Learning;Letters;Long-Term Effects;Machine Learning;Magnetic Resonance Imaging;Methods;Modality;model building;Modeling;multimodal data;multimodality;Nerve Degeneration;Nervous System Disorder;neuroimaging;Noise;nonalzheimer dementia;novel;Participant;Pathogenesis;Pathology;Patients;Performance;Positron-Emission Tomography;pre-clinical;predictive modeling;Process;Resources;Scanning;Shapes;Site;Software Tools;Source;Structure;structured data;Syndrome;Systematic Bias;tau Proteins;Techniques;Testing;Texture;Time;tool;United States National Institutes of Health;Validation;White Matter Hyperintensity;Work

PROJECT_TITLE: Large-scale harmonization and integration of multi-modal ADNI data for the early detection of Alzheimer's disease and related dementias


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE  This project will develop, optimize and evaluate a rapid 5-minute knee MRI protocol consisting of all clinical sequences and additional T2 mapping sequences, enabling imaging of the whole knee for both morphological and quantitative assessment of joint pathology. The proposed technique explores the acceleration of knee MRI by leveraging the latest deep learning technology combined with novel image acquisition and automatic processing. Given the increasing prevalence of knee osteoarthritis and the overall cumulative knee injuries, our novel imaging methods would offer a unique opportunity to improve joint health care, reduce healthcare costs, and benefit a large population that suffers knee pain and joint discomfort in the United States.

PI_NAMEs: LIU, FANG  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Acceleration;Adult;Advanced Development;Body part;Brain;Cartilage;Clinical;clinical imaging;clinical practice;deep learning;Development;Early Diagnosis;Economic Burden;Evaluation;Foundations;General Population;Goals;Health Care Costs;Health Personnel;Healthcare;healthcare burden;High Prevalence;Image;imaging modality;Imaging Techniques;improved;Incidence;Investigation;joint destruction;Joints;Knee;Knee Injuries;Knee joint;Knee Osteoarthritis;knee pain;Magnetic Resonance Imaging;Maps;Medicare;Methods;Modeling;Morphology;Musculoskeletal;neural network;Noise;novel;operation;Pathology;Patients;Peripheral;Population;Prevalence;prevent;Protocols documentation;Public Health;quantitative imaging;rapid technique;reconstruction;Relaxation;Research;Resolution;Sampling;Scanning;Schedule;Signal Transduction;Slice;Societies;Structure;Techniques;Technology;Time;Tissues;Training;two-dimensional;United States;Validation;Vertebral column

PROJECT_TITLE: Deep Learning Technology for Rapid Morphological and Quantitative Imaging of Knee Pathology

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE In this project we examine how interdisciplinary communication using text messaging can improve delivery of age-friendly care to nursing home (NH) residents and prevent avoidable NH-to-hospital transfer. This study will provide information needed for the development and testing of interventions using convenient, low-cost technologies, like text messaging, to ultimately reduce morbidity and mortality in residents with Alzheimer’s disease or a related dementia.

PI_NAMEs: POWELL, KIMBERLY RYAN (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Acute;Address;Age;Alzheimer's disease related dementia;Caring;Categories;Characteristics;Clinical;Communication;Communication Methods;Complex;cost;Cost Control;Data;data exchange;Data Set;Data Sources;Decision Making;Dementia;Development;Documentation;Electronics;Elements;Emotional;Emotional Stress;evidence base;Expenditure;Flare;Friends;Goals;Health;Health system;high risk;Home Nursing Care;Hospitalization;Hospitals;Impaired cognition;improved;Individual;Interdisciplinary Communication;Intervention;Language;Medical Care Team;Medicare/Medicaid;member;Modernization;Morbidity - disease rate;mortality;Names;Natural Language Processing;novel;Nursing Homes;older adult;Ontology;Outcome;Pathway Analysis;Patients;Pattern;Pharmaceutical Preparations;Population;portability;prevent;Preventive care;Process;Property;Quality of Care;Resource-limited setting;satisfaction;Severities;Social Network;Standardization;Stress;Structure;Symptoms;Technology;Telefacsimile;Telephone;Test Result;Testing;Text Messaging;therapy development;Thinking;Time;transmission process;Update;Visiting Nurse;Vocabulary;Vulnerable Populations;Work

PROJECT_TITLE: Reducing Avoidable Nursing Home-to-Hospital Transfers of Residents with ADRD: An Analysis of Interdisciplinary Team Communication using Text Messages

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The proposed training program will enable the applicant to apply generative adversarial network (GAN) architecture to widely available pre-operative evaluation notes and data from an anesthesia information management system (AIMS) to improve patient outcomes. The training will comprise the creation of (1) one GAN framework for generating realistic synthetic low-resolution AIMS data from patient profiles in pre- operative evaluation notes and (2) The second GAN framework for generating synthetic high-resolution intraoperative physiological data from low-resolution AIMS data and patient profiles. From this, the applicant aims to (1) investigate the feasibility of using GAN architecture to improve pre-operative risk assessment and (2) create a database for intraoperative high-resolution multivariate time series gathered from both low- resolution AIMS data and pre-operative evaluation notes, which can be used to train machine learning algorithms for a future real-time intraoperative clinical-decision support system designed to assist anesthesia providers deliver safer care.

PI_NAMEs: ZHANG, FEI  (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Adverse event;Algorithms;Anesthesia procedures;Award;Caring;Cessation of life;clinical decision support;Clinical Decision Support Systems;Clinical Investigator Award;Complex;Data;Data Analyses;Data Collection;Data Display;Data Management Resources;data resource;Data Science;Data Security;Databases;Decision Making;design;Devices;Environment;Evaluation;Event;experience;Future;generative adversarial network;generative models;Goals;hemodynamics;high risk;improved;Individual;Injury to Kidney;Intervention;Intraoperative Complications;Intraoperative Monitoring;Knowledge;large scale data;Lead;Learning;Machine Learning;machine learning algorithm;machine learning model;Management Information Systems;Mathematics;Measures;Medical Records;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;myocardial injury;network architecture;network models;Neural Network Simulation;novel;Nurses;older adult;older patient;Operating Rooms;Operative Surgical Procedures;patient safety;Patient-Focused Outcomes;Patients;Pattern;Perioperative;Physiologic Monitoring;Physiological;prediction algorithm;prevent;Prevention;privacy preservation;Process;profiles in patients;programs;Provider;Records;Regulation;Research;Research Personnel;Resolution;Risk;Risk Assessment;risk prediction;Science;Series;skills;Spottings;Stroke;success;synthetic data;System;Time;tool;Training;Training Activity;training data;Training Programs;virtual

PROJECT_TITLE: Synthesizing Intraoperative Multivariate Time Series with Conditional Generative Adversarial Networks

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Older adults from vulnerable populations, including those who face disparities in care, and those with complex multimorbidity and dementia, experience poor health and quality of life, and while their numbers are growing, the research workforce needed to address their needs is small. We propose an interdisciplinary research training program to enable scholars, especially those without formal geriatrics or gerontology training, to develop the skills needed to become independently funded researchers in this field and to conduct research that leads to improvements in the health and quality of life of older, vulnerable adults.

PI_NAMEs: FEDERMAN, ALEX D (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Alzheimer's disease related dementia;Caring;Chronic;older adult;Research Training

PROJECT_TITLE: Research Training for the Care of Vulnerable Older Adults with Alzheimer’s Disease and Related Dementias and Other Chronic Conditions


PHR: PROJECT NARRATIVE. In this proposal, we will develop new CD38 targeted peptide-based PET imaging probes for multiple myeloma (MM), and explore basic cellular and molecular pathways as well as spatial relationships that govern MM- associated “CD38 expression and enzymatic activity”, and therapeutic response.

PI_NAMEs: SHOKEEN, MONICA  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Address;Affinity;African ancestry;Age;age related;Antibodies;Antibody Therapy;Antigens;Benchmarking;Binding;Biological;biological systems;Bone marrow biopsy;Cells;Cessation of life;Clinic;Clinical;Combined Modality Therapy;Data;Diagnostic tests;Disease remission;Engraftment;Enzymes;Epitopes;extracellular;Family history of;fluorodeoxyglucose;Generations;Goals;Green Fluorescent Proteins;Half-Life;Hematologic Neoplasms;Human;human model;human old age (65+);Image;imaging agent;Imaging Device;imaging probe;imaging study;Immune;Immunotherapy;in vivo;innovation;Integral Membrane Protein;Knowledge;Lead;Link;Luciferases;male;Malignant lymphoid neoplasm;Metabolism;Modeling;Molecular;Molecular Biology;Molecular Conformation;molecular imaging;Monitor;Monoclonal Antibodies;Monoclonal Antibody Therapy;mouse model;Multiple Myeloma;Mus;neoplastic cell;Nicotinamide adenine dinucleotide;novel;Order Coleoptera;Organ;Pathogenesis;Pathway interactions;patient variability;Patients;Peptides;Phage Display;Phenotype;Positron-Emission Tomography;protein aminoacid sequence;Proteins;quantitative imaging;Radiolabeled;Radiopharmaceuticals;receptor;receptor expression;Recurrent disease;Refractory;Refractory Disease;Relapse;Resistance;response;Risk Factors;Sampling Errors;SCID Mice;serial imaging;sex;Signaling Molecule;small molecule;Spatial Distribution;spatial relationship;spatiotemporal;standard of care;subcutaneous;targeted treatment;Technology;Testing;Therapeutic antibodies;Therapeutic Uses;Tracer;treatment response;tumor;Tumor Tissue;Universities;uptake;Virginia

PROJECT_TITLE: Exploring CD38 molecular biology and imaging in multiple myeloma pathogenesis

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Members of the mechanosensitive ion channel family act as biological sensors by decoding mechanical stimuli to regulate physiological processes such as touch and food sensation, mechanical pain, and wound healing. The proposed study is relevant to NIH's mission because it will provide the molecular basis by which fatty acids modulate the response of mechanosensitive ion channels, including the PIEZO family. The proposed research is relevant to public health because combining dietary fatty acids might be a new strategy to ameliorate mechanical pain and accelerate wound healing.

PI_NAMEs: VASQUEZ, VALERIA  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Acceleration;Animal Model;behavioral study;Biosensor;Caenorhabditis elegans;Cell membrane;Cell Volumes;Diet;Dietary Fatty Acid;Disease;Equilibrium;Erythrocyte volume;Esthesia;Family;Fatty Acids;Food;Functional disorder;Genetic study;Goals;Health;Human;In Vitro;in vivo;infancy;Ion Channel;Life;mechanical allodynia;mechanical stimulus;Mechanics;member;Membrane;Mission;Molecular;mouse model;Musculoskeletal Development;Nervous System Disorder;Neuronal Differentiation;novel;Pain;Pathology;pharmacologic;Pharmacology;Physiological;Physiological Processes;Piezo 2 ion channel;Piezo ion channels;Play;Polyunsaturated Fatty Acids;Proprioception;Public Health;Research;response;Role;Saturated Fatty Acids;Signal Transduction;Skeletal Development;Therapeutic Effect;tool;Touch sensation;United States National Institutes of Health;wound healing

PROJECT_TITLE: Mechanosensitive Ion Channels Modulation by Membrane Composition

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Pediatric

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE This is a collaborative project University of Pittsburgh Medical Center (UPMC) Children’s Hospital of Pittsburgh Heart Institute (CHP-HI) to study heart disease in children and young adults with other clinical core research centers within the NHLBI Pediatric Heart Network. The goal of this project is to develop new knowledge and understanding that will lead to improved diagnosis and new therapies to lessen the burden of both congenital and acquired heart disease in a diverse population of children and young adults. CHP-HI is eager to collaborate with other clinical centers, the data-coordinating center, the NHLBI staff, and industry partners to complete ongoing studies and initiate innovative new investigations.

PI_NAMEs: GOLDSTEIN, BRYAN H (contact);OLIVIERI, LAURA J

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Adult;Agreement;Area;Basic Science;Bioinformatics;bioinformatics infrastructure;Brain;Cardiac;Cardiology;care delivery;Caring;Child;Childhood;Clinical;clinical care;clinical center;Clinical Research;Clinical Services;Clinical Trials;cohort;Collaborations;Communication;Communities;community engagement;Community Hospitals;community organizations;Community Services;Complex;congenital heart abnormality;cost;Coupled;dashboard;Data;Data Coordinating Center;data harmonization;data integration;data management;data registry;data sharing;deprivation;design;Diagnosis;Echocardiography;electronic health database;Electronic Health Record;Eligibility Determination;Enrollment;Ensure;Equity;experience;Faculty;follow-up;Funding;Future;geographic population;Goals;Grant;health care service;Healthcare Systems;Heart;Heart Diseases;heart imaging;Heart Research;Hospitals;Image;imaging biomarker;improved;indexing;industry partner;Infrastructure;innovation;Institution;International;Investigation;Knowledge;Lead;Leadership;Letters;Location;Medical center;member;minority patient;Modeling;multidisciplinary;National Heart, Lung, and Blood Institute;New York;novel;novel strategies;novel therapeutics;Ohio;Operative Surgical Procedures;Outcome;Outpatients;patient population;Patients;Pediatric Hospitals;peer;Pennsylvania;Population;Population Heterogeneity;Productivity;programs;Protocols documentation;recruit;Registries;Research;Research Personnel;Resources;Role;Rural;Site;sound;Stable Populations;success;surgical service;System;Techniques;tool;Underrepresented Minority;Universities;Veterans;Visit;West Virginia;young adult

PROJECT_TITLE: Pediatric Heart Network University of Pittsburgh

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Q (O2)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE Congenital heart disease affects ~1% of live births and is the leading cause of mortality from birth defects; acquired heart disease affects thousands more each year. The Pediatric Heart Network is a multicenter research enterprise that has conducted 23 multicenter research studies including 12 clinical trials; 7 studies are currently recruiting participants. Boston Children’s Hospital has participated in the PHN since its inception in 2001 and here presents exemplary credentials to be a PHN Clinical Research Center in the next grant cycle.

PI_NAMEs: DE FERRANTI, SARAH D (contact);NEWBURGER, JANE W.

PROJECT_TERMS: Adult;Affect;Artificial Intelligence;Award;Big Data;biomedical informatics;Boston;Calendar;Cardiac;Cardiovascular system;Caring;Catheterization;Child;Child Health;Childhood;Clinical;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;Cohort Studies;Collaborations;Congenital Abnormality;congenital heart abnormality;Credentialing;Data;Data Coordinating Center;data integration;Data Management Resources;Data Science;Databases;Decision Making;Dedications;design;Development;Diagnosis;Doctor of Philosophy;Echocardiography;Electronic Health Record;Enrollment;Environment;Equitable healthcare;Equity;equity, diversity, and inclusion;Ethnic Origin;Evaluation;experience;Faculty;Funding;Future;gender diverse;gender diversity;gene discovery;Goals;Grant;health care delivery;health disparity;health equity;Health equity research;Heart;Heart Diseases;Human Resources;Image;improved;improved outcome;Individual;individualized medicine;Inequity;Infrastructure;innovation;Institution;Institutional Review Boards;Interdisciplinary Study;Intervention;Leadership;leadership development;life span;Live Birth;Machine Learning;Magnetic Resonance Imaging;marginalized population;Medical;Mentors;Methodology;mid-career faculty;Minority;Minority Groups;Mission;Modeling;Molecular;mortality;Multicenter Studies;neurodevelopment;novel;Nursing Research;Office of Administrative Management;operation;Operative Surgical Procedures;Outcome;Outcome Study;Outpatients;participant enrollment;participant retention;Patient Recruitments;Patients;Pediatric Hospitals;Pharmacy facility;Population;Process;Productivity;programs;prospective;Protocols documentation;Public Health Informatics;Race;randomized trial;recruit;Registries;Reporting;Research;Research Assistant;Research Infrastructure;Research Methodology;Research Personnel;research study;Research Training;Resources;Review Committee;Schedule;Scholarship;Science;sex;Site;study population;success;Talents;Techniques;Therapeutic;timeline;Visit;X-Ray Computed Tomography

PROJECT_TITLE: Pediatric Heart Network Clinical Research Centers - Boston Children's Hospital


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE: Building on a portfolio of long-standing expertise at the interface of RNA biology and single molecule biophysics, we will apply advanced mechanistic enzymology approaches to a broad set of RNAs involved in the regulation of transcription and translation, thus seizing the opportunities that continue to arise from discoveries of functional RNAs. In addition, we will push the limits of our single molecule approaches to be able to probe increasingly complex biological machineries and mechanisms in which RNA secondary and tertiary structures govern the function of the cellular gene expression machinery .

PI_NAMEs: WALTER, NILS G (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affect;Award;Biochemical;Biological;Biology;Biophysics;Catalytic RNA;Cell Extracts;Cell Physiology;Cells;Complex;Coupling;Encapsulated;Enzymatic Biochemistry;Fluorescence Microscopy;Funding;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;Genetic Transcription;Goals;Human;Kinetics;Length;Life;Ligands;Messenger RNA;nanomachine;nanoscale;Outcome;particle;Process;reconstitution;Research;RNA;RNA chemical synthesis;RNA Folding;RNA Interference;single molecule;Site;Structure;Structure-Activity Relationship;Thermodynamics;Thinking;Time;Transcript;Transcriptional Regulation;Translations;United States National Institutes of Health;Untranslated RNA;Work

PROJECT_TITLE: The RNA nanomachines of gene expression dissected at the single molecule level

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

PHR: PROJECT NARRATIVE Toddlers who are late talkers are at risk for continuing language impairments and also have high rates of mental health impairments, estimated to range from 30-70%, yet the precursors and trajectories of these conditions are rarely studied, especially in tandem. Here, we will use existing data and add new measures to our ongoing multi-cohort study to accelerate the pace of discovery to create risk calculators that can predict children’s late talking status, language, and mental health impairments. Crucially, we will examine promotive factors that help children’s positive development and employ a health-equity lens that ensures our risk calculators are accurate for children from historically marginalized and under-resourced environments who are often incorrectly missed or diagnosed.

PI_NAMEs: LUBY, JOAN L.;ROGERS, CYNTHIA ELISE;WAKSCHLAG, LAUREN S (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: Acceleration;Age;Algorithms;base;Behavior;Birth;Brain;Caregivers;Child;Child Language;cognitive neuroscience;cohort;Cohort Studies;Communication;Communities;Competence;Data;Detection;Development;Diagnosis;Dimensions;Early identification;emotion dysregulation;Emotional;Ensure;Environment;Equity;experience;Frequencies;Funding;Grant;health equity;Impaired health;Impairment;improved;Inequity;Joints;Language;Language Development;language impairment;machine learning method;marginalization;Measures;Mental Health;model design;Modeling;National Institute of Mental Health;Nursery Schools;Outcome;outcome prediction;Parents;Phenotype;Psychopathology;Resources;Risk;Sampling;social;Subgroup;Testing;Toddler;Translations;Vocabulary

PROJECT_TITLE: Optimizing prediction of preschool psychopathology from brain: behavior markers of emotion dysregulation from birth: A computational, developmental cognitive neuroscience approach


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative: The proposed research is relevant to public health because it is expected to deliver new transformations that will increase the efficiency of drug synthesis and enable access to unique analogs of biologically important small molecules. Thus, we expect these synthetic tools to facilitate the development of next-generation small molecule therapeutics.

PI_NAMEs: ALEXANIAN, ERIK JOHN (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Alkenes;analog;Catalysis;chemical synthesis;Chemicals;Chlorides;Complex;Coupling;Derivation procedure;Development;drug development;drug synthesis;functional group;Goals;Health;Hydrogen Bonding;innovation;Medicine;Metals;Natural Products;next generation;novel;Pharmaceutical Preparations;Planet Earth;programs;Public Health;Reaction;Reagent;Research;Site;small molecule;small molecule therapeutics;tool

PROJECT_TITLE: Innovative Transformations of Fundamental Synthetic Building Blocks

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


NIH_SPENDING_CATS: Charcot-Marie-Tooth Disease;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Rare Diseases

ORG_CITY: ALBANY

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: PROJECT NARRATIVE We are proposing to develop an authentic model for PMP2-associated Charcot-Marie-Tooth disease to determine whether the PMP2 p.Ile50del mutation leads to a detrimental gain-of-function in Schwann cells.

PI_NAMEs: BELIN, SOPHIE  (contact);POITELON, YANNICK

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Ablation;Adult;Affect;Anabolism;analog;Animal Model;Antibodies;Axon;Binding;Cell Physiology;Charcot-Marie-Tooth Disease;Childhood;Communities;Complex;CRISPR/Cas technology;Cytosol;Data;Deletion Mutation;Demyelinations;Development;Devices;disabling symptom;Disease;dominant genetic mutation;early onset;Electrophysiology (science);Endoplasmic Reticulum;extracellular;Face;Fatty Acids;Foundations;Frameshift Mutation;Functional disorder;Future;gain of function;Genes;Goals;Heterozygote;Homozygote;Human;Impairment;in silico;in vivo;Individual;Inherited;Injury;insight;Investigation;Knock-in Mouse;Label;Limb structure;Lipid Bilayers;lipid biosynthesis;Lipids;long chain fatty acid;loss of function;Membrane;Metabolic;middle age;misfolded protein;Modeling;Molecular;Molecular Biology;Molecular Chaperones;molecular modeling;Monitor;Morphology;mosaic;Motor;mouse model;Mus;Muscle Weakness;Muscular Atrophy;mutant;Mutation;Myelin;Myelin Proteins;myelination;NCAM1 gene;Nerve;Nerve Fibers;Nerve Pain;Nervous System Disorder;Neuropathy;new therapeutic target;Nonesterified Fatty Acids;Nuclear;Occupational Therapy;Orthopedic Surgery;Orthopedics;pain relief;painful neuropathy;Pathogenesis;Pathogenicity;Pathologic;Patients;Peripheral;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Persons;Pharmaceutical Preparations;Phenotype;Physical therapy;pre-clinical;Pre-Clinical Model;Property;protein misfolding;protein structure;Proteins;Regulation;Research;Resources;Schwann Cells;Sensory;structural biology;Structure;Testing;Therapeutic;Time;trafficking;uptake;Western Blotting

PROJECT_TITLE: Exploring the Pathophysiology of CMT1G

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-N (03)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Clinical Research;Emerging Infectious Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Racial and Ethnic Minority Health Research;Rare Diseases;Tuberculosis

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Among Alaska Natives in Alaska, tuberculosis (TB) remains endemic in communities and is a leading cause of morbidity and mortality. Today, Alaska Native communities continue to have the highest rates of TB disease in the United States, and most TB cases occur in villages that remain far from health centers. In this proposal, we seek to evaluate the accuracy and feasibility of using several recent advancements for portable chest radiography and non-invasive tongue swab sampling for the screening and diagnosis of TB disease within Alaska Native communities.

PI_NAMEs: DRAIN, PAUL K (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: 5 year old;Acceleration;acceptability and feasibility;Adult;Alaska;Alaska Native;Artificial Intelligence;case finding;Child;Clinical;Clinical Research;cohort;Collection;Communities;community barrier;community setting;computer aided detection;computer-assisted diagnostics;cost comparison;cost effective;cost effectiveness;Country;Data;Devices;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Sensitivity;Diagnostic tests;diagnostic tool;digital;digital imaging;Disease;Effectiveness;experience;feasibility testing;Goals;Health;improved;Individual;Infrastructure;innovation;Measures;Modality;Molecular;Morbidity - disease rate;mortality;Mycobacterium tuberculosis;Native Americans;novel;Nucleic Acid Amplification Tests;Outcome;Persons;Pharmaceutical Preparations;portability;Process;programs;Pulmonary Tuberculosis;Qualifying;radiological imaging;radiologist;real-time images;remote communities;Research;Research Infrastructure;Resource-limited setting;Roentgen Rays;sample collection;Sampling;screening;Screening procedure;Site;South Africa;Specimen;Sputum;standard of care;Swab;Symptoms;System;Technology;Testing;Thoracic Radiography;Time;Tongue;tool;transmission process;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;United States;World Health Organization;X-Ray Medical Imaging

PROJECT_TITLE: Improving Native American Health Through Community-based Screening and Diagnostic Testing for Tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-P (55)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: PUBLIC HEALTH SIGNIFICANCE According to the estimates of the National Cancer Institute over 30,000 Americans will die due to hepatocellular carcinoma (HCC) this year alone; however, regrettably, current therapies provide only limited clinical benefit, and thus, new and more effective therapies are urgently needed for treating HCC effectively. Using an integrative functional genomics approach (humanized NSG mice with human immune system and in vivo CRISPR screening), we have identified NSD3 as a driver and therapeutic target in HCC. The studies proposed in this application will have a significant impact on the biology and therapy of HCC by establishing NSD3 as a driver of HCC and by providing novel drugs for effective treatment of HCC patients.

PI_NAMEs: WAJAPEYEE, NARENDRA  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Accounting;American;Antineoplastic Agents;Automobile Driving;B-Lymphocytes;bevacizumab;Biology;Cancer Patient;Cell Culture Techniques;Cells;Cessation of life;Chromatin Remodeling Factor;Clinic;Clinical;clinical translation;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;CRISPR screen;Culture Media;Development;DNA copy number;DNA Methylation;Drug Targeting;drug testing;druggable target;effective therapy;effectiveness testing;epigenome;exome sequencing;functional genomics;Gene Expression;Genetic;Genetic Transcription;Genomic approach;Goals;Growth;Growth Factor;Guide RNA;Hematopoietic stem cells;hepatocellular carcinoma cell line;Histone-Lysine N-Methyltransferase;Human;humanized monoclonal antibodies;humanized mouse;Immune;Immune system;Immunocompetent;Immunocompromised Host;immunodeficient mouse model;In Vitro;in vivo;inhibitor;innovation;Interleukin-15;Intervention;liver cancer model;Liver Fibrosis;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Methods;MicroRNAs;Modeling;Molecular;Morphologic artifacts;mouse model;Mus;National Cancer Institute;Natural Killer Cells;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutics;Nuclear Receptors;Nude Mice;Organ;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;pre-clinical;Primary carcinoma of the liver cells;programmed cell death ligand 1;Protac;Proteomics;Public Health;receptor binding;Regimen;Regulation;response;RNA;Role;Sampling;screening;SET Domain;stem cell engraftment;System;T-Lymphocyte;Tertiary Protein Structure;The Cancer Genome Atlas;Therapeutic Agents;therapeutic target;Transgenic Organisms;Translating;Translations;Transplantation;tumor;tumor growth;Tumor Immunity;Tumor Suppression;United States;Validation;Vascular Endothelial Growth Factors

PROJECT_TITLE: CRISPR and Humanized mice-based Discovery of a Novel Drug target for HCC Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (J2)]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

ORG_STATE: MD

PHR: Project Narrative  This work will uncover the mechanisms of bacterial ferrous homeostasis and of eukaryotic post- translational arginylation, both of which are linked to human disease. Results from this proposal hold the promise to aid in the development of therapeutics to abrogate bacterial virulence and to treat neurological, cardiovascular, and developmental diseases in humans.

PI_NAMEs: SMITH, AARON T (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Bacteria;Binding Proteins;Biochemical;Biological Process;Cardiovascular Diseases;Cardiovascular system;combat;Complex;design;Development;developmental disease;Disease;Enzymes;Evolution;Future;Generations;Goals;Health;Homeostasis;Human;human disease;In Vitro;in vivo;Infection;Intervention;Iron;iron (III) reductase;Link;Malignant Neoplasms;Mediating;Membrane;Metalloproteins;Methods;Microbial Biofilms;Nervous System Disorder;neurogenesis;pathogen;Pathogenicity;Pathway interactions;Positioning Attribute;programs;protein function;Proteins;Research Personnel;Research Project Summaries;Siderophores;small molecule;Structure;System;therapeutic development;Therapeutic Intervention;Time;Translations;Virulence;Virus Diseases;Work;Yeasts

PROJECT_TITLE: Deciphering the Mechanisms of Pathogenic Ferrous Iron Acquisition and Eukaryotic Post-Translational Arginylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-H (56)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project narrative Arkansas has significant differences in health outcomes across race, ethnicity, gender, age, and geographic location. The Translational Research Institute supports research that drives new discoveries from laboratories, clinics, and communities to the development of new treatment approaches, medications, or disease prevention strategies that will improve the health of individuals and communities. Over the next seven years, we will identify strategies that most effectively propel research discoveries forward to change the health of individuals and communities in Arkansas.

PI_NAMEs: JAMES, LAURA P (contact)

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: Acceleration;Address;Adopted;Age;Area;Arkansas;Awareness;care delivery;career;Clinic;Clinical and Translational Science Awards;Clinical Practice Guideline;Clinical Research;clinical trial enrollment;Collaborations;college;Communication;Communities;community academic partnership;community based participatory research;community based research;Community Health Aides;COVID-19 pandemic;Creativeness;Criminal Justice;dashboard;Data;Development;Disease;disorder prevention;Disparate;Electronics;Elements;Environment;Ethnic Origin;Evidence based practice;experience;Future;Gender;Geographic Locations;Geography;Grant;Health;health care disparity;health difference;health disparity;health equity promotion;Health Promotion;implementation science;implicit bias;improved;Individual;Informatics;innovation;Institution;Knowledge;Laboratories;life span;Medical;Mentorship;National Center for Advancing Translational Sciences;novel therapeutic intervention;Outcome;Pathway interactions;Performance;Pharmaceutical Preparations;Prevention strategy;Primary Care;Process;Program Development;programs;Public Health;Race;recruit;Reduce health disparities;Research;Research Institute;Research Personnel;Research Support;Research Training;Resources;response;Rural;rural area;Rural Health;Rural health equity;Rural Population;Science;science education;sharing platform;Site;skills;Students;System;Testing;Time;Training;Training Programs;Translation Process;Translational Research;undergraduate student;Underrepresented Populations;Universities;uptake;Vision;Vulnerable Populations;Workforce Development

PROJECT_TITLE: Expanding Translational Science in Arkansas

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-9 (01)]