NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Duchenne/ Becker Muscular Dystrophy;Genetics;Heart Disease;Muscular Dystrophy;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Duchenne muscular dystrophy heart failure is ubiquitous and is now the leading cause of death, however there is limited mechanistic understanding of disease progression and currently no effective treatments to prevent or limit the progression. This proposal is designed to train Dr. Forum Kamdar in cardiac tissue engineering and extracellular matrix dynamics, to aid in her transition to an independently funded physician-scientist in neuromuscular cardiomyopathy. In this project, she will develop a 3D heart model using dystrophic heart cells derived from patient skin cells, using advanced physical technology to understand the molecular basis of this devastating disease, and to test ideas for developing effective treatments.

PI_NAMEs: KAMDAR, FORUM D (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 3-Dimensional;Acceleration;adrenergic stress;Animal Model;Animal Muscular Dystrophy;Basic Science;bioink;Biological Models;Calcium;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiology;Cardiomyopathies;Cardiovascular system;career;career development;Cause of Death;Cell Adhesion;Cells;Clinical;clinically significant;Complex;design;Development;Development Plans;Disease;Disease Progression;Duchenne cardiomyopathy;Duchenne muscular dystrophy;dystrophic cardiomyopathy;Dystrophin;effective therapy;Event;Exercise;exon skipping;Exons;experience;Extracellular Matrix;Fibrosis;Foundations;Funding;gene correction;Generations;Genes;Genetic Transcription;Glycoproteins;Goals;Heart;heart cell;Heart failure;Homeostasis;Human;human induced pluripotent stem cells;improved;induced pluripotent stem cell derived cardiomyocytes;insight;K-Series Research Career Programs;Laboratories;laboratory experience;mdx mouse;mechanotransduction;Membrane;Mentors;Mentorship;Methods;Minnesota;Modeling;Molecular;multidisciplinary;Muscle;Muscular Dystrophies;Mutation;Nature;neuromuscular;novel;novel therapeutics;Onset of illness;Patients;Phenotype;Physicians;pressure;prevent;Production;programs;Proliferating;Proteins;Pump;Reading Frames;Research;responsible research conduct;restoration;Role;Scientist;Skin;Stress;Structure;Technology;Testing;Therapeutic;three-dimensional modeling;Time;Tissues;Training;transcriptome sequencing;Universities

PROJECT_TITLE: Progressive loading of a human dystrophic cardiomyopathy 3D model to mimic disease and evaluate therapeutic

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: RICHLAND

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BATTELLE PACIFIC NORTHWEST LABORATORIES

ORG_STATE: WA

PI_NAMEs: JACOBS, JON  (contact);LOKSHIN, ANNA E.;QIAN, WEI-JUN

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TITLE: PSP Omics Center of Acute to Chronic Pain Signatures


NIH_SPENDING_CATS: Chronic Pain;Pain Research

PI_NAMEs: JACOBS, JON  (contact)

PROJECT_TERMS: Acute;chronic pain;Clinical;clinical center;clinical research site;Collaborations;Communication;Communities;Data;data dissemination;data integration;data sharing;Ensure;experimental study;Fostering;Generations;Goals;Home;Institution;Laboratories;Leadership;meetings;operation;outreach;Pacific Northwest;Persons;programs;Protocols documentation;Reagent;Research;Research Activity;Resource Allocation;Resources;Role;Schedule;Site Visit;success;Teleconferences;timeline;tool;United States National Institutes of Health;Work;working group

PROJECT_TITLE: PSP-Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ETTN-P]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Nashville

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Alzheimer’s Disease is a significant public health concern, and identifying opportunities for early intervention is critical to developing effective interventional strategies. Diffusion weighted magnetic resonance imaging (DW- MRI) has shown that subtle changes in cerebral white matter are prognostic for disease progression, but quantitative interpretation of these measures in existing large studies is confounded by protocol, scanner, and site effects. This study will translate recent advances in harmonization of DW-MRI to improve specificity of white matter microarchitecture metrics (aim 1), translate connectivity analyses (aim 2) for existing large Alzheimer’s Disease neuroimaging studies, and enable robust single subject inference for abnormality detection and prognosis (aim 3).

PI_NAMEs: LANDMAN, BENNETT A. (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Affect;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;American;Anatomy;Architecture;Biological Markers;biomarker development;Blood Vessels;Brain;Brain Mapping;Calibration;Cerebrum;Chemicals;clinical application;Clinical Research;Clinical Sciences;Clinical Trials;Cognitive;cohort;Coupled;Data;Data Analyses;data integration;Data Set;Databases;deep neural network;Detection;Diffusion Magnetic Resonance Imaging;Disease;disease prognostic;Disease Progression;Dissection;Early Diagnosis;Early Intervention;Educational workshop;effective intervention;Ensure;Evaluation;FDA approved;Functional disorder;Goals;Healthcare;Histology;Image;imaging modality;imaging study;improved;in vivo;Individual;innovation;Intervention;Investigation;Machine Learning;magnetic resonance imaging biomarker;Maps;Measures;Modality;Modeling;Morphologic artifacts;neuroimaging;Neurons;Noise;Normal Range;novel therapeutics;open source;Patient Care;Patients;Pharmaceutical Preparations;Physiological;Prognosis;Property;prospective;Prospective cohort;Protocols documentation;Public Health;Quality Control;Research;Resources;Role;Scanning;Sensitivity and Specificity;Severity of illness;Site;Software Tools;Specificity;Structure;success;System;Techniques;Tissue Model;Tissues;tool;tractography;Translating;translational impact;Uncertainty;Variant;virtual;virtual biopsy;Visualization software;white matter;white matter change

PROJECT_TITLE: Controlling Quality and Capturing Uncertainty in Advanced Diffusion Weighted MRI

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE TRIM5 proteins constitute a powerful innate cellular defense machinery against important human pathogens such as HIV- 1 and other retroviruses. The continuing goal of this R01 project is to understand the detailed molecular mechanisms by which TRIM5 recognizes and inhibits HIV-1. Our studies on this naturally-evolved antiviral enriches understanding of the fundamental mechanisms of HIV-1 replication, and also identifies viral vulnerabilities that can be exploited to fight HIV/AIDS.

PI_NAMEs: PORNILLOS, OWEN  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TITLE: Structural Virology of Tripartite Motif Proteins


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Lesions that arise in the genome compromise its integrity and need to be properly repaired since loss of repair or misrepair leads to chromosome loss and genomic rearrangements, which are associated with many tumor types, in particular of the breast and ovary. Defects in repair also sensitize tumors to particular therapies. This project addresses fundamental questions about the tumor suppressors BRCA2 and RAD51 paralogs, which are involved in homology-direct repair, and addresses underexplored areas of research, including how cells lose the intact copy of genes, how mutant genes revert, and DNA repair in the fallopian tube.

PI_NAMEs: JASIN, MARIA  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Address;Affect;Alleles;Area;BRCA2 gene;Breast;cancer therapy;Cell Death;Cells;chromosome loss;Cisplatin;Constitution;crosslink;Defect;DNA biosynthesis;DNA Damage;DNA Repair;DNA Sequence Rearrangement;Epithelium;Frequencies;Genes;Genome;Genome Stability;Genomic Instability;Germ-Line Mutation;Goals;Heterozygote;Homeostasis;Homologous Protein;homologous recombination;Individual;interest;Lesion;Loss of Heterozygosity;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Mammalian Oviducts;Molecular Analysis;mutant;Mutation;Ovary;paralogous gene;Pathway interactions;Poly(ADP-ribose) Polymerase Inhibitor;Predisposition;protein function;Proteins;repair function;repaired;Research;Resistance;Serous;targeted treatment;therapy resistant;Tissues;treatment response;tumor;tumor initiation;Tumor Suppressor Proteins

PROJECT_TITLE: Homology-directed repair: BRCA2 and RAD51 paralogs


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Digestive Diseases;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

PHR: Project Narrative This application brings together the clinical strengths and large acute pancreatitis patient population of Virginia Mason Medical Center's Digestive Disease Institute and Benaroya Research Institute's expertise in autoimmunity and type 1 diabetes to understand the incidence, clinical course, and potential mechanisms of autoimmune mediated diabetes after acute pancreatitis. The theme of this application is that knowledge gained from studying autoimmune diabetes after pancreatitis will provide key insights as to mechanisms of disease in typical type 1 diabetes. Our underlying hypothesis is that failure or delay in resolving the immune response to tissue injury in genetically at risk individuals leads to engagement of the adaptive immune system, antigen spreading, and ongoing beta cell destruction in type 1 diabetes occurring both naturally and post-acute pancreatitis.

PI_NAMEs: GREENBAUM, CARLA J (contact);KOZAREK, RICHARD ANTHONY

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Acute;acute pancreatitis;Adaptive Immune System;Address;Animals;Autoantibodies;Autoimmune Diabetes;Autoimmune Process;Autoimmunity;Beta Cell;Biological Models;Cadaver;Cell Death;cell injury;Cells;chronic pancreatitis;Classification;Clinical;clinical center;Data;Data Analyses;Development;Diabetes Mellitus;Digestive System Disorders;Disease;Endocrine;Epitope spreading;Event;Exocrine pancreas;Failure;follow-up;Frequencies;gene environment interaction;genetic association;glucose tolerance;Goals;Human;Immune;Immune response;Immunologics;Immunotherapy;Incidence;Individual;Infiltration;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Investigation;islet autoimmunity;Knowledge;longitudinal, prospective study;Mediating;Medical center;Meta-Analysis;Metabolic;Natural History;Necrosis;Pacific Northwest;Pancreas;Pancreatitis;Pathogenesis;patient population;Phenotype;Population;Prediabetes syndrome;Process;Registries;repository;Research Institute;response;Risk;Role;Sampling;Specimen;Testing;Time;tissue injury;Virginia;Writing

PROJECT_TITLE: Type 1 Diabetes in Acute Pancreatitis Consortium, Pacific Northwest Clinical Center: Immune Pathogenesis of Post-Pancreatitis T1D


ADMINISTERING_IC: AR

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Osteoarthritis;Pain Research;Rehabilitation

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Total Knee Arthroplasty (TKA) improves the pain from end-stage osteoarthritis, but the substantial swelling early after surgery is theorized to lead to decreases in strength and physical function. We will explore whether an inelastic, adjustable compression garment reduces swelling and improves strength and function compared to the current standard of care (elastic compression). This study has high potential to transform current postsurgical management and rehabilitation recommendations after TKA with a simple, cost-effective intervention and to improve the health of the millions of individuals who will undergo TKA annually.

PI_NAMEs: BADE, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acute;Address;Articular Range of Motion;Atrophic;attenuation;Clinical;Clinical Trials;Cohort Studies;comparison control;Compression Stocking;cost effective intervention;Deep Vein Thrombosis;Degenerative polyarthritis;design;disability;Effectiveness;Elasticity;Equilibrium;fall risk;functional decline;functional loss;functional outcomes;Gait speed;Health;improved;in vivo;Individual;Infection;insight;Intervention;Joints;Knee;Knee Osteoarthritis;knee replacement arthroplasty;Laboratories;Life;Limb structure;Mediating;older adult;Operative Surgical Procedures;Outcome;Pain;pain reduction;Participant;Pathway interactions;Patient Outcomes Assessments;patient population;Performance;Physical Function;Positioning Attribute;Postoperative Period;prevent;primary endpoint;primary outcome;programs;quadriceps muscle;randomized, controlled study;Recommendation;Rehabilitation therapy;Research;Role;Sample Size;standard of care;Standardization;Swelling;Testing;theories;Thromboembolism;Trauma;Western Ontario and McMaster Universities Arthritis Index

PROJECT_TITLE: Swelling Management after Total Knee Arthroplasty

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PI_NAMEs: LENERT, ALEKSANDER  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Acne;Address;Adult;Agreement;Area;autoinflammatory diseases;Binding;Bioinformatics;bone;career;career development;Childhood;Chronic;Chronic disability;chronic pain;Clinic;Clinical;Clinical Investigator;clinical phenotype;Clinical Research;Clinical Sciences;Clinical Trials;Code;cohort;Data;design;Development;Diagnosis;Disabling;Disease;disease phenotype;Early Diagnosis;Early Intervention;Effectiveness;Environment;Etiology;experience;FDA approved;follow-up;Future;Genes;Genetic;genetic variant;genome sequencing;Genotype;Goals;Hyperostosis;IL1B gene;Image;imaging modality;Immunosuppression;improved;Inflammation;Inflammatory;Infrastructure;inhibitor;Interleukin-1;Iowa;Joints;Knowledge;Large-Scale Sequencing;Lesion;longitudinal course;Magnetic Resonance Imaging;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Modeling;modifiable risk;Multicenter Studies;Mutation;novel;novel marker;observational cohort study;Observational Study;Osteitis;Osteomyelitis;Outcome;Pain;Pathogenicity;Pathway interactions;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Positioning Attribute;Predictive Value;Productivity;prospective;Prospective Studies;Psychometrics;recruit;Reference Standards;Reporting;Research;Research Design;Research Methodology;Research Personnel;Rheumatism;Risk;Risk Factors;RNA Splicing;Role;Science;Signaling Protein;Site;skills;Specificity;Spinal Diseases;Statistical Data Interpretation;stem;Sterility;Symptoms;Syndrome;Synovitis;Systemic Scleroderma;targeted treatment;Techniques;Testing;tool;Training;Translational Research;treatment guidelines;treatment response;treatment strategy;Universities;Variant;variant detection;Visit;whole genome;Work

PROJECT_TITLE: Investigating Disease Activity, Bone Damage and Interleukin-1 Genes in Adult SAPHO Syndrome and Chronic Nonbacterial Osteomyelitis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Gene Therapy;Genetics;Liver Disease;Muscular Dystrophy;Orphan Drug;Rare Diseases

ORG_CITY: ROCKVILLE

ORG_NAME: AAVOGEN, INC.

ORG_STATE: MD

PHR: RELEVANCE TO PUBLIC HEALTH. The loss of striated muscle mass and function in patients with a rare neuromuscular disease significantly compromises quality of life and is often fatal. The proposed studies will develop novel adeno-associated viral capsids for improving the efficacy and safety of muscle-focused gene therapeutics. Ultimately, these capsids will be incorporated into a gene therapy program for inclusion body myositis and Duchenne muscular dystrophy and will be licensed to other commercial programs targeting these and other neuromuscular disease indications.

PI_NAMEs: RODGERS, BUEL  (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: adeno-associated viral vector;Adult;Age;Agreement;animal breeding;Award;Binding;Businesses;Capsid;Chronic;Clinical;Clinical Trials;Codon Nucleotides;Collaborations;comparative efficacy;Complementary DNA;Cytokeratin-8 Staining Method;Development;Diagnosis;Directed Molecular Evolution;Disease;Dose;Dose Limiting;drug development;drug efficacy;Drug or chemical Tissue Distribution;Drug usage;Duchenne muscular dystrophy;Effectiveness;Engineering;Epitopes;gene therapy;Generations;Goals;Heparin;Hepatotoxicity;high risk;imaging approach;Immune response;Impairment;improved;In Vitro;in vivo;Inclusion Body Myositis;innovation;Integrin Binding;Intellectual Property;Legal patent;Licensing;Limb-Girdle Muscular Dystrophies;Link;Liver;liver function;manufacture;manufacturing cost;medication safety;Methods;Muscle;muscle form;Muscle function;Muscular Atrophy;Myopathy;neuromuscular;Neuromuscular Diseases;novel;older patient;Patients;Penetrance;Pharmaceutical Preparations;pre-clinical;prevent;Program Development;programs;promoter;Property;Public Health;Quality of life;rational design;receptor binding;Recombinants;Risk;Safety;Serotyping;Sialic Acids;Skeletal Muscle;Smad7 protein;Specificity;Spinal Muscular Atrophy;Striated Muscles;success;Sulfate;Testing;therapeutic development;therapeutic gene;Tissues;Toxic effect;trait;Treatment Cost;Tropism;vector;Viral;Virus Receptors;Wasting Syndrome

PROJECT_TITLE: Development of optimized adeno-associated viral capsids for muscle gene therapy


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Immunotherapy;Infectious Diseases;Lung;Nanotechnology;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative We developed a targeted macrophage therapy with broad applications for HIV and TB. This innovative proposal advances the conceptual and mechanistic knowledge of stimulation of the immune system to treat infectious diseases and this novel immune-stimulating drug delivery nanoparticle platform. By incorporating beta glucan onto the nanoparticle's surface, the resulting immune stimulation is independent of its therapeutic cargo.

PI_NAMEs: REYNOLDS, JESSICA L (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Acids;Address;Adsorption;Affect;alveolar epithelium;Alveolar Macrophages;Antibiotics;aspirate;Bacillus;bactericide;beta-Glucans;Binding;biocompatible polymer;biodegradable polymer;Bronchoalveolar Lavage;Cessation of life;Chitosan;co-infection;Communicable Diseases;cytokine;Data;dectin 1;Disease;Dose;Dose Limiting;Drops;Drug Delivery Systems;Drug Kinetics;Drug Targeting;Effectiveness;efficacy evaluation;efficacy study;Encapsulated;experimental study;extracellular;Formulation;Glycolates;Granuloma;Histology;HIV;HIV Envelope Protein gp120;HIV-1;HIV/TB;Human;human disease;Immune system;Immunologic Stimulation;Immunotherapeutic agent;In Situ;In Vitro;in vivo;in vivo Model;Inbred BALB C Mice;Inflammatory;Inhalation;Innate Immune System;innovation;Knowledge;Learning;Lesion;Lung;Macrophage;Methods;microbial;Modeling;mouse model;Mus;Mycobacterium tuberculosis;nanoformulation;nanoparticle;nanoparticle delivery;nanotechnology platform;Nature;Necrosis;Necrotic Lesion;novel;Oropharyngeal;Oxygen;pathogen;Pathogenesis;Persons;Phagolysosome;Phagosomes;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Production;Property;Proteins;Reactive Nitrogen Species;receptor;Research Personnel;Rifampin;Rifamycins;Risk;Science;side effect;skills;Surface;Testing;Therapeutic;Time;TNF gene;Treatment Protocols;Tuberculosis;tuberculosis drugs;tuberculosis granuloma;tuberculosis treatment;uptake;Vaccines;Viral Proteins;Virulent

PROJECT_TITLE: Immunotherapeutic nanoparticles: Implications for the treatment of tuberculosis and HIV

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative: Chronic obstructive pulmonary disease (COPD) is a leading cause of death in the United States and worldwide. In this proposal, we combine whole genome sequence analysis of COPD and related pulmonary function traits with comprehensive gene expression and proteomic measures from multi-ethnic cohorts including African American, Hispanic and European ancestry participants. Our study will leverage these multiple sources of data to identify genes, biomarkers and biological mechanisms contributing to risk of COPD.

PI_NAMEs: CHO, MICHAEL H.;MANICHAIKUL, ANI WANG (contact)

PROGRAM_OFFICER_NAME: GAN, WEINIU

PROJECT_TERMS: Acceleration;Address;Affect;African American;African American population;African ancestry;Age;biobank;Biological;Biological Markers;bronchial epithelium;candidate marker;candidate validation;Cause of Death;Cell Line;Cells;Chronic Obstructive Pulmonary Disease;cigarette smoking;Classification;cohort;Communities;CRISPR/Cas technology;Data;Data Set;Disease;disorder risk;Drug Targeting;Epidemiology;ethnic diversity;Ethnic Origin;European ancestry;experimental study;Family;Forced expiratory volume function;Funding;Gene Expression;Gene Frequency;Gene Proteins;Gene Targeting;General Population;Genes;Genetic;genetic association;genetic resource;Genetic Risk;Genetic Variation;Genome;genome wide association study;genome-wide;genomic locus;Genomics;Health;Hispanic;Hispanic ancestry;improved;Latino;Lung;Maps;Measures;Methods;Minor;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;Multiomic Data;multiple data sources;multiple omics;National Heart, Lung, and Blood Institute;novel;novel marker;Participant;Pathogenesis;Pathway interactions;Performance;Peripheral Blood Mononuclear Cell;pharmacologic;phenome;Phenotype;polygenic risk score;Population;population based;programs;Proteomics;Publishing;pulmonary function;Pulmonary function tests;Pulmonology;Quantitative Trait Loci;Race;rare variant;Research;Resources;Risk;Risk Factors;risk prediction;risk prediction model;risk variant;Sample Size;Sampling;Sequence Analysis;Signal Transduction;smoking cessation;Structure of parenchyma of lung;Target Populations;Tissues;trait;Trans-Omics for Precision Medicine;transcriptome sequencing;transcriptomics;United States;Update;Validation;Variant;Vital capacity;Whole Blood;whole genome;X Chromosome

PROJECT_TITLE: Integrative genomic, transcriptomic and proteomic studies of pulmonary function and COPD

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_DEPT: PEDIATRICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The Clinical and Translational Science Collaborative (CTSC) at Case Western Reserve University has created a solid foundation to enhance the quantity and quality of Clinical and Translational Science (CTS) among its partners. This proposal brings an enhanced focus on health equity reflected in the theme Catalyzing Linkages to Equity in Health (CLE Health) and expands its reach to research professionals and special populations through the addition of two new partners to join our core group of five independent collaborators. The CTSC’s collaborative interdisciplinary environment coalesces around a shared mission to improve health and eliminate disparities by 1) facilitating and expediting innovation in multicenter CTS, 2) supporting novel approaches that address gaps in CTS, and 3) training a robust, diverse CTS workforce at all levels.

PI_NAMEs: MCCOMSEY, GRACE A (contact)

PROGRAM_OFFICER_NAME: DOYLE, JAMIE MIHOKO

PROJECT_TERMS: Academia;Acceleration;Address;African American population;Appointment;Award;Chronic;Chronic Care;Chronic Disease;Cities;Clinic;Clinical;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;collaborative environment;Communities;community engagement;community setting;Data;design;Devices;Diagnostic tests;Disadvantaged;Discipline;Disparity;disparity elimination;disparity gap;Dissemination and Implementation;Diverse Workforce;Economics;Effectiveness;Elderly;Elements;Ensure;Environmental Risk Factor;Equity;Ethics;experience;Faculty;Federally Qualified Health Center;Foundations;Funding;Generations;Goals;Grant;Growth;Health;health disparity;health equity;health equity promotion;Healthy Eating;Heart failure;high risk population;Hispanic Populations;HIV;Hypertension;implementation strategy;improved;Industry;Infant Mortality;Information Dissemination;innovation;Institution;Intervention;Investments;Laboratories;Leadership;Lesbian Gay Bisexual Transgender Queer;Life Expectancy;Link;Medical;Medical center;medical schools;Medicine;Methods;Minority Groups;Mission;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutics;Ohio;opioid mortality;Outcome;Participant;Patients;Persons;Pharmaceutical Preparations;Play;point-of-care diagnostics;poor health outcome;Population;Positioning Attribute;primary care practice;Privatization;Procedures;Process;programs;Public Health;Public Health Informatics;recruit;Rehabilitation device;Research;research clinical testing;Research Personnel;Resource-limited setting;Resources;Role;Rural;rural area;rural dwellers;Safety;Services;Site;social;sociocultural determinant;Solid;Special Population;structural determinants;Structural Racism;success;System;Technology;Testing;Training;Training and Education;Training Programs;Translation Process;Translational Research;translational research program;translational scientist;Underrepresented Minority;Underrepresented Populations;United States Department of Veterans Affairs;Universities;University Hospitals;Vulnerable Populations;Work;Workforce Development

PROJECT_TITLE: Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Nanotechnology;Neurodegenerative;Neurosciences

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: Project Narrative  Many patients with retinal degenerative diseases are eventually suffering vision loss due to no therapeutic treatment. While electrode-based retinal prostheses have been most widely used to restore photoreceptor functions, they face many hurdles when this method is applied to a high-resolution neural stimulation. Based on direct optical stimulation, the proposed thermal stimulator will simplify its safe implementation and significantly improve spatial and temporal resolution over the current methods.

PI_NAMEs: SEO, SANG-WOO  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TITLE: Development of a photothermal stimulator array for controlled neuron stimulation


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative  The research program outlined in this proposal is relevant to public health because it will establish novel machine learning algorithms for modeling the molecular mechanisms of pathologic changes, enable robust drug response prediction, and ensure the fairness and generalizability of the analytical methods for biomedical data. The proposed approaches are relevant to NIGMS’s mission of supporting the development of computational methods for understanding basic biological questions and advancing disease treatment.

PI_NAMEs: YU, KUN-HSING  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;advanced disease;Adverse effects;Algorithms;analytical method;Biological;Computing Methodologies;Data;Data Analyses;Development;Disease;drug response prediction;Ensure;Goals;improved;Informatics;innovation;Knowledge;Machine Learning;machine learning algorithm;machine learning model;Methodology;Methods;Mission;Modeling;Modernization;Molecular;Molecular Biology;molecular modeling;multidimensional data;multiple omics;National Institute of General Medical Sciences;novel;Pathologic;Pathology;Pattern Recognition;Pharmaceutical Preparations;Pharmacology;Phenotype;Population Heterogeneity;predictive modeling;programs;Public Health;Research;Research Activity;response;Signal Transduction;success;Techniques;Toxic effect;Vision

PROJECT_TITLE: Robust, Generalizable, and Fair Machine Learning Models for Biomedicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This project aims to develop a risk stratification model for predicting both failure of optimal medical therapy and the optimal timing of intervention for uncomplicated Type B aortic dissection patients.

PI_NAMEs: LESHNOWER, BRADLEY GRAHAM (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: 4D MRI;Acute;Alternative Therapies;Anatomy;Aneurysm;Anti-Hypertensive Agents;Aorta;Aortic Aneurysm;Aortic Rupture;Biomechanics;Chest;Chronic Phase;Classification;Clinical;clinical risk;Computerized Medical Record;Data;data repository;Databases;Death Rate;demographics;Development;Diagnosis;Disease;Dissection;Early Intervention;Echocardiography;Engineering;experimental study;Failure;Follow-Up Studies;Goals;Growth;Harvest;hemodynamics;high risk;Hospital Mortality;Image;imaging study;improved;Incidence;indexing;Intervention;Liquid substance;Machine Learning;machine learning model;Magnetic Resonance Imaging;Maps;Mechanics;Medical;Medical Imaging;Modeling;Morbidity - disease rate;mortality;Operative Surgical Procedures;Organ;Outcome;Patients;Performance;Phase;Predictive Factor;predictive modeling;Procedures;Property;prospective;recruit;repaired;Risk;Risk Factors;risk stratification;Rupture;Secondary to;serial imaging;Series;Shapes;Stress;Structure;surveillance imaging;Survival Rate;Techniques;Tissues;Treatment Failure

PROJECT_TITLE: Risk stratification of uncomplicated type B aortic dissection using clinical and engineering analysis

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: NEW ORLEANS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative (Relevance) There is no vaccine for enterotoxigenic E. coli (ETEC) infection, despite the fact that it is major cause of diarrhea disease. Here, we will test samples from a ETEC vaccine clinical trial and seek to understand why some formulations result in better immune responses after vaccination.

PI_NAMEs: NORTON, ELIZABETH B (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Adjuvant;Antibodies;Antigen-Presenting Cells;Antigens;Area;Automobile Driving;Avidity;B-Lymphocytes;Bacterial Adhesins;Biological Assay;Biological Markers;biomarker identification;biomarker validation;Calcium;Campylobacter coli;Cells;Cellular Immunity;Child;Clinical;clinical trial analysis;Clinical Trials;cohort;Combined Vaccines;CREB1 gene;Cyclic AMP;cytokine;Dermal;design;Development;Diarrhea;diarrheal disease;Dose;enterotoxigenic Escherichia coli;Escherichia coli;Escherichia coli Infections;Escherichia coli Vaccines;Evaluation;Event;first-in-human;Formulation;Freezing;Future;Genetic;Genetic Transcription;Goals;Homing;Human;immune activation;Immune response;Immunity;Immunization;immunogenicity;Immunoglobulin-Secreting Cells;Immunologic Stimulation;Immunologics;In Vitro;in vivo;Individual;Infection;insight;integrin alpha4beta7;Intramuscular;Intramuscular Injections;Knockout Mice;lipid metabolism;Longevity;Measures;Memory;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Military Personnel;Modeling;Molecular;mouse model;Mucosal Immunity;mutant;novel;Oral;Outcome;Oxidative Phosphorylation;Peripheral Blood Mononuclear Cell;Phase;Phase I Clinical Trials;phase I trial;potential biomarker;Proteins;Public Health;Reporting;response;Risk;Role;Route;Safety;Sampling;Serious Adverse Event;Serum;Serum Proteins;Shapes;Signal Transduction;Stains;Subunit Vaccines;T memory cell;Testing;Toxin;Toxoids;transcription factor;Vaccination;vaccination outcome;Vaccine Antigen;Vaccine Clinical Trial;vaccine development;vaccine efficacy;vaccine immunogenicity;vaccine strategy;vaccine trial;vaccine-induced immunity;Vaccines

PROJECT_TITLE: Evaluation of Memory Responses and Biomarkers from a Phase IEnterotoxigenic Escherichia coli (ETEC) Intramuscular SubunitVaccine with dmLT Adjuvant

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: TAMPA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative. This proposal is relevant to public health and will have an important positive impact because there are currently no therapeutic strategies designed to alleviate negative affective states and cognitive dysfunction that accompany alcohol dependence and withdrawal and persist into protracted abstinence to promote excessive alcohol consumption. The benefits of the current proposal are the inducible and conditional genetic as well as chemogenetic manipulation of kappa-opioid receptor systems in combination with comprehensive behavioral phenotyping in motivational, negative affective and executive function domains. This research should provide a foundation for personalized therapeutics designed to reduce maladaptive behavioral regulation in alcohol dependence.

PI_NAMEs: WALKER, BRENDAN M (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Abstinence;Acute;Affect;Affective;alcohol abuse therapy;alcohol comorbidity;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol measurement;Alcohol Phenotype;alcohol relapse;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Amygdaloid structure;Animal Model;Anxiety;Behavior;Behavioral;behavioral phenotyping;Cell Nucleus;Characteristics;Chronic;chronic alcohol ingestion;Cognitive;cognitive control;Complement;Cre lox recombination system;CRISPR/Cas technology;Data;Dependence;design;Development;Disease;Dissection;Dopamine;dopaminergic neuron;Dynorphins;effective therapy;Excision;executive function;Foundations;Gene Expression;Genes;Genetic;genetic approach;genetic manipulation;Goals;Health;Heavy Drinking;Human;Impaired cognition;Infusion procedures;interdisciplinary approach;kappa opioid receptors;knock-down;Knowledge;Literature;maladaptive behavior;Medial;Mediating;Memory impairment;Mental Depression;Midbrain structure;Motivation;mRNA Expression;National Institute on Alcohol Abuse and Alcoholism;negative affect;neural circuit;neuroadaptation;Neurons;novel strategies;novel therapeutic intervention;Nucleus Accumbens;Outcome;overexpression;Pathogenicity;Pattern;personalized medicine;personalized therapeutic;Phenotype;Prefrontal Cortex;Principal Investigator;Public Health;Publishing;Rat Transgene;Rattus;Receptor Gene;Recovery;reduce symptoms;Regulation;Relapse;Research;response;Role;Self Administration;Self Medication;Short-Term Memory;Strategic Planning;success;System;Testing;Therapeutic;therapeutic target;therapeutically effective;therapy design;therapy development;treatment adherence;treatment strategy;Ventral Tegmental Area;Viral;virus genetics;welfare;Withdrawal;Work

PROJECT_TITLE: Oprk1-regulated neurocircuitry and phenotypes of alcohol use disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-S(02)M]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: AUGUSTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Intracerebral hemorrhage (ICH) is a major public health problem with no effective treatment. Given the emerging role of epigenetic mechanisms in the pathophysiology of ICH, if the hypotheses of this proposal are confirmed, the data from this grant will identify histone deacetylase 3 (HDAC3) as a target for therapeutic intervention.

PI_NAMEs: SUKUMARI-RAMESH, SANGEETHA  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acetylation;Acute;Address;Anti-Inflammatory Agents;Antiinflammatory Effect;Attenuated;attenuation;Biological Assay;Brain;Brain hemorrhage;Brain Injuries;Brain region;Cell Line;Cerebral Edema;Cerebral hemisphere hemorrhage;clinically relevant;Complex;conditional knockout;Data;Death Rate;disability;DNA Binding;effective therapy;Epigenetic Process;Exhibits;Functional disorder;Gene Expression;Genes;Genetic;glial activation;Goals;Grant;HDAC1 gene;HDAC2 gene;HDAC3 gene;Hematoma;Hemin;Hemoglobin;Histone Acetylation;Histone Deacetylase;Histone Deacetylase Inhibitor;Histone H3;Histones;Hospitals;improved;Inflammatory;inhibitor;Injury;Innate Immune System;insight;Investigation;knock-down;Macrophage;Macrophage Activation;Mass Spectrum Analysis;Mediating;Mediator;Microglia;Molecular;molecular targeted therapies;mouse model;Mus;Myelogenous;neurobehavioral;neuroinflammation;Neurologic Deficit;Neurological outcome;neuroprotection;next generation;novel;Outcome;Patient-Focused Outcomes;Patients;Phagocytosis;pharmacologic;Phenotype;Pre-Clinical Model;Prognosis;promoter;Protein Isoforms;Proteins;Proteomics;Public Health;Regulation;Regulator Genes;Reporting;Resolution;Role;sex;Signal Transduction;Site;Sorting;Stimulus;Stroke;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;transcription factor;Transgenic Animals;Transgenic Mice;Transgenic Organisms;Vorinostat

PROJECT_TITLE: HDAC3 as a therapeutic target for intracerebral hemorrhage

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The mechanisms driving poor birth outcomes for Latina mothers are understudied and not fully understood. This application will examine anticipatory racism stress and area-level racism as two proposed novel mechanisms predicting low birthweight and preterm birth among this group.

PI_NAMEs: PEREZ, AMANDA DANIELLE (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: adverse birth outcomes;African American Women;allostatic load;Area;Attention;Automobile Driving;Big Data;Biological;Birth;Categories;Characteristics;Chronic;County;Data;Data Analyses;Data Collection;Development;Disparity;Environment;ethnic disparity;ethnic minority population;Event;experience;Foundations;Future;Geographic Locations;Goals;Health;High birth weight infant;Hostility;Hypertension;Incidence;Individual;Intervention;Investigation;Latina;Latina Population;Latinx;Left;Length;Link;Literature;long-standing disparities;Low Birth Weight Infant;low socioeconomic status;Maternal Health;Measures;Methodology;Mothers;neglect;novel;Outcome;outcome disparities;Pathway interactions;Patient Self-Report;perceived discrimination;Phase;Premature Birth;Preparation;Psychometrics;psychosocial stressors;Qualitative Research;Race;racial bias;racial discrimination;racial disparity;racial minority;racial minority population;racism;Reporting;Research;Resource Allocation;Risk;Sampling;Social Desirability;Social Environment;social stress;Stress;stressor;Structural Racism;Subgroup;System;telomere;Testing;Time;tool;Training;Vital Statistics;White Women

PROJECT_TITLE: Racism-related stress and birth outcomes among Latinas: New tools for maximizing conceptual and methodological validity


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The Mayo Clinic Center for Clinical and Translational Sciences (CCaTS) accelerates innovations in clinical research and partners with our stakeholders and communities to improve patient care and human health for all people. It supports scientists who bring new discoveries to clinical practice, trains a diverse multidisciplinary workforce prepared to address the urgent health care needs of all communities in a rapidly changing environment and works closely with other research centers across the country to share innovative approaches. Project Narrative Page 290

PI_NAMEs: GAROVIC, VESNA D (contact)

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: Acceleration;Address;Advocate;base;Caring;Classification;Clinic;Clinical and Translational Science Awards;clinical center;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engagement;community partners;Competence;Country;COVID-19;COVID-19 pandemic;digital;digital health;Education;Elements;Environment;equity, diversity, and inclusion;Event;Faculty;Funding;Goals;graduate student;Health;health care service organization;health disparity;health equity;health equity promotion;health inequalities;Health system;Healthcare;Human;improved;Incubators;Individual;Informatics;innovation;Institution;Interdisciplinary Study;interest;Investments;Justice;Knowledge;Leadership;Learning;medical schools;Medical Students;member;Methodology;Methods;Minnesota;Mission;multidisciplinary;National Center for Advancing Translational Sciences;novel;operation;pandemic disease;Patient Care;Patients;Persons;Population;Positioning Attribute;Postdoctoral Fellow;Process;programs;Research;Research Personnel;Resources;response;Role;Rural Population;Scientist;Secure;social disparities;Structural Racism;synergism;Talents;Technology;theories;tool;Training;Training and Education;Translational Research;Translations;Trust;underserved community;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Mayo Clinic Center for Clinical and Translational Science (CCaTS)


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Kidney Disease

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will seek fundamental knowledge regarding the reasons why some forms of glomerular diseases progress as people age to explain why chronic kidney disease is highest in the elderly.

PI_NAMEs: SHANKLAND, STUART JAMES (contact);WESSELY, OLIVER

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Address;Adriamycin PFS;Adult;Affect;Age;age related;aged;Aging;Antibodies;Cardiovascular system;Cell Aging;Cell Culture Techniques;Cell Nucleus;Cell Physiology;Cells;Chronic;Chronic Kidney Failure;Cicatrix;Clinical;Coupled;cytokine;Data;Data Analyses;Data Set;Deterioration;Dialysis procedure;Disease;Disease Progression;Elderly;End stage renal failure;Environment;Exhibits;Experimental Designs;Experimental Models;Focal and Segmental Glomerulosclerosis;gain of function;Gene Expression;gene function;Glomerular Filtration Rate;glomerulosclerosis;Goals;Grant;Growth Factor;Health;healthspan;healthy aging;Heterogeneity;Human;human data;human disease;human old age (65+);Immunomodulators;Incidence;Inflammatory;injured;Injury;Injury to Kidney;innovation;Kidney;Kidney Diseases;Knowledge;life span;loss of function;mathematical model;Methodology;middle age;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;Mutant Strains Mice;novel;Nuclear RNA;old mice;older patient;Outcome;overexpression;Pathway interactions;Patients;Persons;Phenotype;Pilot Projects;podocyte;Population;premature;Premature aging syndrome;Prevalence;primary endpoint;Public Health;Publishing;Renal function;Renal glomerular disease;Research;Research Personnel;Risk;Role;secondary endpoint;senescence;Severity of illness;Signal Transduction;Stress;Testing;Time;TP53 gene;transcriptome sequencing;transcriptomics;Transgenic Mice;translational impact;Work

PROJECT_TITLE: The Intersection of Podocyte Disease and Aging

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Clinical Research;Pain Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE  Achilles tendinopathy is a painful condition that does not fully resolve in 20-60% of patients following conservative treatment. In this ancillary study, we will determine how calf muscle coordination impacts tendon disease and patient outcomes using our innovative high-density surface electromyography interface. By determining the mechanistic link between muscle coordination and outcomes, we will generate critical new evidence to support personalized rehabilitation protocols aimed at improving outcomes.

PI_NAMEs: BAXTER, JOSH  (contact);VITALE, FLAVIA

PROJECT_TERMS: achilles tendon;Affect;Ancillary Study;Ankle;Architecture;Award;Biofeedback;Biological Models;Biomechanics;Biometry;Chronic;Clinical;clinical care;clinical efficacy;Clinical Research;cohort;Complex;Data;density;Disease;Disease Outcome;Disease Progression;Electromyography;end stage disease;evidence base;Exercise;exercise rehabilitation;expedited review;experience;Experimental Models;Fascicle;Flexor;foot;functional outcomes;Gastrocnemius Muscle;Guidelines;healing;Image;imaging biomarker;improved outcome;Individual;innovation;Isometric Contraction;Knee;Lateral;Link;Literature;Measures;Medial;Mediating;Monitor;Multi-Institutional Clinical Trial;Muscle;Neuromechanics;Operative Surgical Procedures;Outcome;Pain;pain outcome;pain symptom;Parents;participant enrollment;Pathogenesis;Pathologic;Pathology;Patient-Focused Outcomes;Patients;Pattern;personalized care;Process;profiles in patients;Property;Protocols documentation;randomized, clinical trials;reduce symptoms;Rehabilitation therapy;Reporting;Research;Schedule;Soleus Muscle;Standardization;Stress;Surface;Symptoms;Tendinopathy;Tendon structure;Testing;Time;Torque;treadmill;ultrasound;Walking;Work

PROJECT_TITLE: Defining neuromechanical mechanisms of Achilles tendinopathy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The present study aims to determine whether transcranial direct current stimulation (tDCS) over the left angular gyrus (AG) along with verbal learning of semantically related and unrelated word lists will improve word list learning performance in two variants of probable Alzheimer’s disease (AD): typical, amnesia-predominant AD and atypical, aphasia-predominant AD (also known as logopenic variant primary progressive aphasia with AD pathology). In addition, we will evaluate two brain mechanisms of tDCS-effects, i.e., whether functional connectivity between the stimulated area and its connections in the default mode network, and the inhibitory neurotransmitter GABA modulate word-list learning in the two AD variants. Finally we will identify neural, cognitive and physiological predictors such as sleep, that may moderate tDCS effects, in order to be able to identify responders to tDCS and optimize neuromodulatory treatments of neurodegenerative disorders.

PI_NAMEs: TSAPKINI, KYRANA  (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: actigraphy;Affect;Aftercare;Age;aging related disease;alternative treatment;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amnesia;angular gyrus;Anodes;Aphasia;Area;Association Learning;Atrophic;Auditory;Behavior Therapy;Biological Markers;Brain;Brain region;caregiver quality of life;Caregivers;Categories;Characteristics;cingulate cortex;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive task;Collaborations;Complex;Coupling;Development;Diffusion Magnetic Resonance Imaging;Disease;Double-Blind Method;effective therapy;Elderly;Electrical Stimulation of the Brain;Evaluation;Event;Failure;Foundations;Functional Magnetic Resonance Imaging;Future;gamma-Aminobutyric Acid;Gender;Health system;Hippocampus;Image;Impaired cognition;improved;Individual;Inferior frontal gyrus;Intervention;Language;Language Disorders;Learning;learning outcome;Left;lexical retrieval;Magnetic Resonance Spectroscopy;Measures;Membrane Potentials;Memory;Methodology;Multi-Institutional Clinical Trial;Names;Nerve Degeneration;neural;Neurocognitive;Neurodegenerative Disorders;neurological rehabilitation;Neurons;neuropathology;neuroregulation;Neurotransmitters;Oral;Painless;Parahippocampal Gyrus;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Phenotype;Physiological;post intervention;Prefrontal Cortex;Prevalence;prevent;Primary Progressive Aphasia;Probability;Progressive Aphasias;Publishing;Questionnaires;Randomized Controlled Clinical Trials;remediation;Rest;Semantics;Site;Sleep;statistics;Sum;Symptoms;Synapses;Synaptic Transmission;Syndrome;Techniques;Testing;theories;Therapeutic;Therapeutic Effect;Training;transcranial direct current stimulation;treatment effect;Variant;verbal;Verbal Learning;Writing

PROJECT_TITLE: Transcranial direct current stimulation in typical and atypical Alzheimer's disease


PHR: NARRATIVE (OVERALL P01) Dengue is a major public health problem worldwide and is complicated by four distinct yet cross-reactive sero- types, such that prior infection with one serotype can either protect or enhance a subsequent infection with a different serotype – posing a major challenge for vaccine development. This Program Project addresses the critical need to improve understanding of the human antibody and B and T cell response to dengue virus infection and vaccination and to identify immune correlates of protection and pathogenesis. To this end, our consortium of world-renowned investigators is applying state-of-the-art immunological methods in the context of long-term ongoing clinical and epidemiological studies of dengue as well as studies of vaccinated populations and human challenge models.

PI_NAMEs: HARRIS, EVA  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Americas;Antibodies;Antibody Response;Antigenic Specificity;Antigens;arthropod-borne;Asia;Attenuated;Attenuated Vaccines;B-Lymphocytes;Biological Assay;Cellular Immunity;Characteristics;Clinical;Clinical Management;Clinical Research;cohort;Cohort Studies;Collaborations;Computational Biology;Computer Models;Coupled;cross reactivity;Data;data integration;data management;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Dengvaxia;Development;Disease;Disease Outcome;Emerging Communicable Diseases;Ensure;Epidemic;epidemiology study;Epitope Mapping;experience;Exposure to;Flavivirus;Generations;Genetic;Goals;Grant;hospitalization rates;Human;human disease;Humoral Immunities;Immune;Immune response;Immunity;Immunologics;improved;Individual;Infection;Infectious disease threat;inhibiting antibody;Institution;Joints;Lead;Link;Methodology;Methods;Modeling;Molecular Genetics;Monoclonal Antibodies;mosquito-borne;Nicaragua;Outcome;outcome prediction;pathogen;Pathogenesis;Philippines;Placebo Control;polyclonal antibody;Population;Program Research Project Grants;programs;Public Health;Publications;Reagent;Research;research and development;Research Personnel;Resolution;response;Role;Sampling;Serology;Serotyping;Shapes;Specificity;Statistical Models;Support Contracts;System;T cell response;T-Lymphocyte;United States;United States National Institutes of Health;Vaccinated;Vaccination;vaccine candidate;vaccine development;vaccine failure;vaccine safety;vaccine trial;vaccine-induced antibodies;Vaccines;Virus Diseases;ZIKA

PROJECT_TITLE: Protective immunity following dengue virus natural infections and vaccination


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Violence Research;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: NARRATIVE: Finding and addressing sex and gender differences in effective health care research and treatment are critical actions toward the goal of improving the health and wellbeing of all Americans. To achieve this goal, the UK BIRCWH seeks to continue training and supporting our next generation of academic researchers to recognize sex and gender differences in conditions that disproportionately affect Kentuckians. In this training and mentoring program for emerging researchers, we focus on 3 health concerns that disproportionately affect Appalachian Kentuckians: Substance use, violence against women, and lifespan changes.

PI_NAMEs: CURRY, THOMAS E (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Accountability;Address;Aging;Appalachian Region;Appointment;Area;career development;Chronic Disease;Clinical;Collaborations;Communication;Development;Diagnostic;Disease;Doctor of Philosophy;Educational workshop;Environment;experience;Face;Faculty;Funding;Gender;gender difference;Grant;Health;health difference;health disparity;health inequalities;improved;individualized prevention;Interdisciplinary Study;Kentucky;life span;Manuscripts;Mediation;member;Mentors;Mentorship;multidisciplinary;next generation;Outcome;Peer Review;Personnel Management;professor;programs;Public Health;Publications;Research;research and development;Research Personnel;Research Project Grants;Role;Scientist;Secure;Self Care;sex;Sex Differences;skills;Social Network;Source;substance use;success;Technology;tenure track;Therapeutic;Training;Translational Research;United States National Institutes of Health;Universities;Violence;violence against women;Women's Health

PROJECT_TITLE: Kentucky BIRCWH Program: Training the Next Generation of Women's Health Scholars

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(50)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PHR: NARRATIVE (UC BERKELEY, CORE A) Dengue is a major public health problem worldwide, and it is critical to improve our understanding of the human immune response to dengue virus infection and what elements of immune response are associated with protection from or susceptibility to disease. This Program Project should help define immune correlates of protection and contribute to efforts to successfully develop an effective tetravalent dengue vaccine that confers long-term immunity to all four DENV serotypes. The Administrative Core (Core A) will provide crucial coordination functions to ensure regular and fluid exchange of ideas, data, and reagents between P01 investigators as well as compliance with NIH and local institutional requirements.

PI_NAMEs: COLOMA, MARIA JOSEFINA  (contact)

PROJECT_TERMS: Address;Administrative Coordination;Agreement;California;Charge;Collaborations;Communication;Conflict (Psychology);cost;Data;data sharing;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Disease;Documentation;Elements;Ensure;financial conflict of interest;Fostering;Goals;Grant;Human;Human Resources;Immune;Immune response;Immunity;improved;Individual;Infection;Infrastructure;Institution;Institutional Review Boards;Laboratories;Leadership;Liquid substance;Logistics;Mediating;meetings;member;National Institute of Allergy and Infectious Disease;Online Systems;operation;Output;Participant;Persons;Play;Policies;Predisposition;Process;Program Research Project Grants;programs;Protocols documentation;Public Health;quality assurance;Reagent;Reporting;Research Activity;Research Personnel;Role;Sampling;Schedule;Serotyping;Standardization;symposium;Teleconferences;Telephone;Time;United States National Institutes of Health;Universities;Vaccination

PROJECT_TITLE: P01 Administration Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

PHR: NARRATIVE: CORE B Dengue is a viral disease with a high global burden, yet currently, the only licensed dengue vaccine cannot be widely administered because it can increase severity of dengue disease. Comprehensive characterization of the protective and pathogenic features of immunity in the context of natural dengue and dengue vaccines is urgently needed to improve control efforts. Core B will support this Program Project, which directly addresses these themes, by: epidemiological and phylogenetic analyses of natural infection and vaccine cohorts; experimental designs, sampling strategies, and analysis plans for within and cross-Project studies; and application of statistical and machine learning approaches to interpret high-dimensional adaptive immune characteristics and to identify immune correlates of protection, pathogenesis, and dynamics of anti-dengue virus immunity.

PI_NAMEs: KATZELNICK, LEAH  (contact)

PROJECT_TERMS: Address;Affect;Age;Antibodies;Antibody Response;Antigens;B-Lymphocytes;California;Case/Control Studies;Cellular Immunity;Characteristics;Child;Childhood;Classification;Clinical;cohort;Cohort Studies;Collaborations;Computational Biology;Correlation Studies;cross reactivity;Data;Databases;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Dengvaxia;design;Disease;Epidemiology;epidemiology study;Evolution;experience;Experimental Designs;flexibility;Geography;Goals;Helper-Inducer T-Lymphocyte;high dimensionality;Humoral Immunities;Immune;Immunity;Immunologic Markers;Immunologics;improved;Incidence;Individual;Infection;Licensing;Linear Models;Link;Longevity;Machine Learning;machine learning method;machine learning model;Maintenance;Maps;Measures;Memory B-Lymphocyte;Methods;Modeling;multidimensional data;neutralizing antibody;Nicaragua;Outcome;Pathogenesis;Pathogenicity;Pediatric cohort;Phylogenetic Analysis;predictive marker;Prevalence;programs;random forest;Recording of previous events;Research;Sampling;Serology;seropositive;Serotyping;Serum;Services;severe dengue;Severities;Severity of illness;Site;statistical and machine learning;Statistical Data Interpretation;statistical learning;Statistical Models;Study of serum;support vector machine;System;T-Lymphocyte;Testing;Universities;Vaccinated;Vaccination;vaccine-induced immunity;Vaccinee;Vaccines;viral transmission;Virus Diseases;Work;ZIKA;ZIKV infection

PROJECT_TITLE: CORE B: Computational Biology and Statistical Modeling


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PHR: NARRATIVE (CORE C) Dengue is a major health problem worldwide and is complicated by 4 distinct yet cross-reactive serotypes. This P01 addresses the critical need to improve understanding of human B and T cell responses to dengue virus infection and vaccination and identify immune correlates of protection from or susceptibility to disease. Core C will continue the Nicaraguan Pediatric Dengue Cohort Study to provide key samples from natural repeat dengue virus infections. It will also ensure efficient management and distribution of samples and data from the cohort and other human subject studies to Projects, collaborate on the selection of samples, and maintain P01 databases and the project workspace.

PI_NAMEs: GORDON, AUBREE L (contact)

PROJECT_TERMS: Address;B-Lymphocytes;Biological;Caring;Characteristics;Child;Child Support;Childhood;Clinical;Clinical Data;Clinical Management;Clinical Research;clinical research site;cohort;Cohort Studies;Collaborations;Communication;Communities;cross reactivity;Data;Data Collection;data dictionary;data exchange;data harmonization;data integration;data management;Data Set;data sharing;data submission;Databases;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Dengvaxia;Deposition;design;Disease;Documentation;Enrollment;Ensure;epidemiologic data;Equipment and supply inventories;Funding Agency;Health;Hospitals;Human;Human Resources;human subject;Immune;Immunity;Immunologics;improved;Infection;instrument;Laboratories;Medical;Michigan;Nicaragua;Nicaraguan;Participant;Persons;Philippines;Phylogenetic Analysis;Play;Predisposition;Procedures;Process;Program Research Project Grants;programs;prospective;Prospective, cohort study;Protocols documentation;Quality Control;Research Personnel;response;Role;Running;sample collection;Sampling;Science;Serotyping;Site;Source;Specific qualifier value;Specimen;Statistical Models;Study Subject;success;T cell response;Universities;unvaccinated;Update;Vaccinated;Vaccination;Vaccines;Viral

PROJECT_TITLE: CORE C: Clinical and Data Management


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PHR: RELEVANCE (PROJECT 1) Dengue is a major public health problem worldwide and is complicated by the existence of four antigenically distinct yet immunologically cross-reactive serotypes. It is critical for development and evaluation of dengue vaccines, treatments and diagnostics to improve our understanding of the human immune response to dengue virus infection and identify what elements of the antibody/B cell response are associated with protection from or enhancement of disease. This project uses state-of-the-art immunological methods in the clinical and epidemiological context of our long-term studies in Nicaragua and synergizes extensively with the other Projects and Cores in the P01.

PROJECT_TERMS: Address;Americas;Antibodies;Antibody Repertoire;Antibody Response;Antibody titer measurement;Antigens;Asia;Attenuated;B-Lymphocytes;Binding;Biological;Biological Assay;Biophysics;California;Characteristics;Child;Childhood;Clinical;clinically relevant;Cohort Studies;Communities;Complex;Computational Biology;cross reactivity;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;design;Development;Diagnostic;Disease;Disease Outcome;Elements;Epidemiology;Epitope Mapping;Epitopes;Evaluation;follow-up;Genotype;Hospitals;Human;human disease;Immune;immune function;Immune response;Immunity;Immunologics;Immunology;improved;Individual;Infection;infection risk;insight;Investigation;Kinetics;Longitudinal Studies;Methods;Molecular Genetics;mosquito-borne;neutralizing antibody;Nicaragua;Nicaraguan;Outcome;Pathogenesis;Persons;Population;predict clinical outcome;Primary Infection;Process;Program Research Project Grants;Prospective, cohort study;Public Health;Reagent;Recombinant Proteins;recombinant virus;Research;Resolution;response;Risk;Risk Factors;Role;Sampling;secondary infection;Serology;Serotyping;severe dengue;Severity of illness;Site;Specificity;Statistical Data Interpretation;Statistical Models;stem;Structure;synergism;System;T cell response;T-Lymphocyte;tool;Universities;Vaccination;Vaccinee;Vaccines;Virus;Virus Diseases;virus identification

PROJECT_TITLE: PROJECT 1: Quality of B Cell and Antibody Responses to Natural Dengue Virus Infections


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: WILLISTON

ORG_NAME: MICROBRIGHTFIELD, LLC

ORG_STATE: VT

PHR: Narrative This project develops a revolutionary new two-photon laser scanning microscope system based on a technological breakthrough called Light Beads Microscopy. This microscope will enable unparalleled in vivo calcium imaging of individual neurons nearly simultaneously in one or more regions of the mouse cerebral cortex, only limited by the rate that it takes the tags to fluoresce, meaning wide volumes of the brain can be recorded within the same time it would take a conventional two-photon microscope to capture a much smaller number of neurons. As a result, new avenues of neuroscience research will become possible providing promise for the elucidation of novel biological mechanisms associated with human brain disease, and ultimately the basis for developing novel therapies to prevent and treat complex brain diseases.

PI_NAMEs: GLASER, JACOB R (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: 3-Dimensional;Animals;Area;base;Behavioral;Biological;Biotechnology;Brain;brain cell;Brain Diseases;Brain region;brain volume;Calcium;calcium indicator;Central Nervous System;Central Nervous System Diseases;Cerebral cortex;Collaborations;commercialization;Communities;Complex;Computer software;design;Development;Electrodes;Feasibility Studies;Fiber;Fluorescence;Functional Magnetic Resonance Imaging;Head;Human;Image;improved;in vivo;in vivo calcium imaging;Individual;innovation;interest;invention;Knowledge;Laboratories;Laser Scanning Microscopy;Lasers;Legal patent;lens;Letters;Light;meter;Methods;Microscope;Microscopy;miniaturize;Morphologic artifacts;Motion;Motor;Mus;Nature;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;Neurosciences;Neurosciences Research;new technology;New York;next generation;novel;novel therapeutics;optical imaging;Performance;Phase;Photometry;Physiologic pulse;Population;prevent;Printing;Process;Production;prototype;research and development;Research Personnel;Resolution;Rodent;Sampling;Scanning;Sensory;Site;Societies;spatiotemporal;Speed;Stimulus;System;Technology;Testing;Time;treatment strategy;two photon microscopy;two-photon;Universities;usability;Validation;Visual;Work

PROJECT_TITLE: System for Volumetric 2-photon Imaging of Neuroactivity Using Light Beads Microscopy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE People living with HIV (PLWH) are living longer due to the success of anti-HIV therapy to suppress HIV, yet they still experience neurocognitive impairments that are worsened in many cases by chronic cocaine abuse, and vice versa. The mechanism for such HIV/cocaine-induced brain dysfunction is not entirely clear; but a component that should be carefully looked at is the aberrant effects of the anti-HIV therapeutic medicines themselves on the brain, which are similar to those induced by HIV and cocaine. In this study, we will determine the effects of such anti-HIV medicines on the brain neurons in the context of HIV/AIDS and cocaine abuse (both cause neurocognitive impairments), and will do so in small animal models of them; and that can potentially shed some lights on the role of anti-HIV drugs in the brain, elucidate how HIV, anti-HIV drugs and cocaine alter the brain function, and provide a novel therapeutic approach for treating HIV/AIDS and cocaine addiction.

PI_NAMEs: HU, XIU-TI  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: abacavir;addiction;Adult;Age;Aging;Animal Model;antagonist;Anti-HIV Agents;Anti-HIV Therapy;Anti-Retroviral Agents;antiretroviral therapy;Astrocytes;astrogliosis;Automobile Driving;Autopsy;Behavior;Brain;brain dysfunction;Brain region;Cause of Death;Cell Communication;Cells;channel blockers;chemokine;Chronic;Cocaine;Cocaine Abuse;Cocaine Dependence;Cocaine use disorder;Cognition;Cognitive;comorbidity;Connexin 43;Connexins;Corpus striatum structure;cytokine;Data;Development;Disease;Electrophysiology (science);excitotoxicity;experience;extracellular;FDA approved;forging;Functional disorder;Glutamates;hippocampal pyramidal neuron;Hippocampus;HIV;HIV-1;HIV-associated neurocognitive disorder;HIV/AIDS;Homeostasis;Human;Hyperactivity;Immune system;Immune System Diseases;improved;in vivo;Individual;Induced Neurons;Injury;innovation;interest;Knowledge;Lamivudine;Learning;Link;Long-Term Effects;Medial;Mediating;Medicine;Memantine;Membrane Potentials;Memory;Messenger RNA;Modeling;Molecular;Molecular Biology;N-Methyl-D-Aspartate Receptors;National NeuroAids Tissue Consortium;neuroAIDS;Neurocognition;Neurocognitive Deficit;Neurodegenerative Disorders;Neurologic;neuron loss;Neuronal Dysfunction;Neurons;neurotoxicity;Nifedipine;NMDA receptor antagonist;novel therapeutic intervention;novel therapeutics;overexpression;patch clamp;Persons;Pharmaceutical Preparations;pharmacologic;Play;Prefrontal Cortex;Prevalence;Process;protein expression;Proteins;Quantitative Reverse Transcriptase PCR;Rat Transgene;Rattus;Regimen;Reporting;Research;Role;Saline;Sampling;Self Administration;success;Therapeutic;Therapeutic Intervention;voltage

PROJECT_TITLE: cART, neuroHIV, cocaine abuse and the mPFC neuron/astrocyte dysfunction


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PHR: The human B cell and antibody response to dengue virus infection is correlated with protection against disease, but the molecular features of this response are incompletely understood. In this project, we will follow up results from the initial Program Project and isolate and characterize in depth human monoclonal antibodies to dengue virus from subjects in the Nicaraguan Pediatric Dengue Cohort study, working in close collaboration with other Projects and Cores. The studies will use serotype-specific and cross-reactive antibody clones and advanced next generation deep sequencing immune repertoire techniques to determine the molecular, structural and genetic basis for the human antibody response to dengue.

PROJECT_TERMS: adaptive immunity;Alanine;Antibodies;antibody engineering;Antibody Response;Antibody Specificity;Antigenic Specificity;Antigens;Area;B-Lymphocytes;Binding;Biochemical;Biology;Child;Childhood;Clone Cells;cohort;Cohort Studies;Collaborations;Collecting Cell;Complement;Complex;cross reactivity;Cryoelectron Microscopy;Crystallography;Data;deep sequencing;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;design;Deuterium;Development;dimer;Disease;E protein;env Gene Products;Epitope Mapping;Epitopes;experimental study;Fab Immunoglobulins;follow-up;Genes;Genetic;Genetic Variation;Goals;Human;human monoclonal antibodies;Hydrogen;Immune;Immunity;Immunologic Receptors;Individual;Infection;inhibiting antibody;insight;Laboratories;Maps;Mass Spectrum Analysis;Measures;Mediating;Memory;Molecular;Molecular Biology;molecular recognition;Monoclonal Antibodies;Mutagenesis;Mutate;neutralizing antibody;neutralizing monoclonal antibodies;next generation;next generation sequencing;Nicaraguan;novel;novel strategies;novel vaccines;Participant;Pattern;Pattern Recognition;Pediatric cohort;peripheral blood;Peripheral Blood Mononuclear Cell;Population;Production;Program Research Project Grants;programs;Property;Reagent;Reporting;Research Personnel;response;Sampling;Sampling Studies;Scanning;secondary infection;Sequence Analysis;Serology;Serotyping;Site;Somatic Mutation;Specificity;Structure;Study Subject;Techniques;Technology;Testing;Vaccination;vaccine candidate;Vaccine Design;vaccine evaluation;Variant;Virus;virus envelope;Work

PROJECT_TITLE: PROJECT 4: Genetic and Structural Basis for Human Antibody Inhibition of Dengue Viruses


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Clinical Research;Immunotherapy;Rheumatoid Arthritis

PHR: PROJECT NARRATIVE Immune checkpoint inhibition (ICI) therapy, while can successfully treat certain cancers, leads to various autoimmune toxicity. We developed new animal models to study how ICI therapy affects immune system and development of autoimmunity. Our data further reveal a link between ICI induced autoimmunity and a subset of rheumatoid arthritis, and point to potential therapeutic opportunities.

PI_NAMEs: ZENG, HU  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Abbreviations;Address;Adverse effects;Affect;Agonist;Animal Model;anti-PD-1;anti-PD-1/PD-L1;anti-PD-L1;anti-PD-L1 antibodies;anti-PD-L1 therapy;anti-PD1 antibodies;Antibodies;Autoantibodies;Autoimmune;Autoimmune Diseases;autoimmune toxicity;Autoimmunity;B-Lymphocytes;Basic Science;Binding;Biological Products;Blocking Antibodies;Cancer Patient;cancer therapy;Cell Physiology;Cells;checkpoint inhibition;checkpoint receptors;Clinical;Clinical Data;Clinical Pathology;clinical practice;Clinical Research;clinically relevant;Cohort Analysis;Collagen Arthritis;comparative;Complement;Data;Deposition;Development;Disease;effector T cell;experimental study;Extracellular Domain;FDA approved;Helper-Inducer T-Lymphocyte;Homeostasis;Human;human subject;humanized mouse;Humoral Immunities;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;immune function;Immune response;Immune system;immune-related adverse events;Immunoglobulins;Immunologics;immunopathology;Impairment;improved;Inflammation;Inflammatory Arthritis;innovation;Intervention;Ligands;Link;Malignant Neoplasms;Mediating;Modeling;Molecular;mouse model;Mouse Strains;Mus;novel;Patients;PD-L1 blockade;pembrolizumab;Personal Satisfaction;pharmacologic;Phenotype;Production;programmed cell death ligand 1;programmed cell death protein 1;Research;Resources;Rheumatism;Rheumatoid Arthritis;Sampling;Signal Transduction;System;systemic autoimmunity;T cell differentiation;T-Lymphocyte;Testing;Th1 Cells;Therapeutic;tool

PROJECT_TITLE: Immune Checkpoint Inhibition and humoral immune response in systemic autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_DEPT: CHEMISTRY

PHR: Project Narrative A better grasp of the factors that influence Mycobacterium tuberculosis permeation will enhance drug discovery efforts for a pathogen of enormous public health significance. We posit that there are multiple barriers to molecule entry, and that the relative importance of each depends on M. tuberculosis cell envelope structure, molecule structure, and the ultimate destination of the molecule within the cell. To test this model, we will develop and deploy methods that are high-throughput and report arrival to specific cell compartments, in turn enabling us to comprehensively query both bacterial and molecular determinants of M. tuberculosis impermeability.

PI_NAMEs: PIRES, MARCOS M. (contact);SIEGRIST, MARY SLOAN

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Adopted;Alkynes;Antibiotic Therapy;Antibiotics;Azides;Bacteria;bacterial genetics;barrier to testing;Biochemical Reaction;Biological Assay;Biology;biomaterial compatibility;Cell Compartmentation;cell envelope;Cell membrane;Cell Wall;Cells;Chemical Structure;Chemicals;cheminformatics;Chemistry;Chimeric Proteins;Cholesterol;combinatorial;Complex;Cytoplasm;Data;Destinations;Detection;Dose;drug discovery;Drug resistance;efflux pump;Environment;Escherichia coli;Fluorescence;Foundations;Gatekeeping;Genes;Genetic;Genetic Determinism;Genetic Screening;grasp;Growth;Home;Hydrophobicity;improved;Label;Libraries;Link;Lipids;Location;Mammalian Cell;Maps;member;Membrane;Metabolic;Methods;model organism;Modeling;Molecular;molecular sieving;mycobacterial;Mycobacterium tuberculosis;non-tuberculosis mycobacteria;Organelles;Organism;pathogen;Pathogenesis;pathogenic bacteria;Penetration;Peptidoglycan;Permeability;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Positioning Attribute;Predisposition;Public Health;Publishing;Reporting;Rifampin;screening;Series;small molecule;Specificity;Structure;Testing;tool;Translations;Tuberculosis;tuberculosis drugs;tuberculosis treatment;uptake;Work

PROJECT_TITLE: Bacterial and Molecular Determinants of Mycobacterial Impermeability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The proposed study will establish the feasibility, acceptability and credibility of a novel live video dyadic resiliency intervention, Resilient Together for Dementia (RT-D), aimed at preventing chronic emotional distress and preserving quality of life among dyads at risk for chronic emotional distress early after a diagnosis of Alzheimer's disease or a related dementia (ADRD). Both persons living with dementia (PWDs) and their spousal care-partners experience high levels of clinically elevated emotional distress, which can become chronic without treatment and negatively impact the health, quality of life, communication, and care-planning of both partners. A tailored dyadic intervention delivered over live video to this at risk population during the window of opportunity when PWDs can participate has the potential to prevent chronic emotional distress and preserve quality of life for PWDs and their loved ones.

PI_NAMEs: BANNON, SARAH  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;Acute;Acute Brain Injuries;Address;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Behavioral;Benchmarking;career;career development;Caregivers;Caring;Chronic;Clinical;clinical care;Clinical Trials;Cognition;Cognitive;Collaborations;Communication;coping;Dementia;dementia care;Development;Diagnosis;Disease;Distress;Early Intervention;Education;effective intervention;effectiveness trial;Elements;Eligibility Determination;Emotional;emotional distress;Ensure;Environment;experience;Family;Family member;feasibility testing;Feedback;flexibility;Focus Groups;Foundations;Future;General Hospitals;Geriatrics;Goals;Health;Home;Hybrids;Impairment;improved;Individual;informal care;innovation;Institution;Intervention;intervention refinement;Interview;Judgment;Language;Link;Long-Term Care;loved ones;Manuals;Massachusetts;Medical;medical schools;medical specialties;meetings;member;Memory impairment;Mentors;Mentorship;Methodology;Methods;mindfulness;Mission;Modeling;Morbidity - disease rate;mortality;Neurologic;Neurologist;novel;Palliative Care;Pamphlets;Participant;Pathologist;Patient Self-Report;Patients;Personal Communication;Personal Satisfaction;Persons;Physicians;Population;Populations at Risk;preference;preservation;prevent;Primary Care;primary care provider;Procedures;Process;programs;promote resilience;Provider;Psychologist;Psychology;psychosocial;Publications;Quality of Care;Quality of life;Randomized;Research;Research Assistant;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;resilience;Resources;Risk;Secure;Self Care;Self Efficacy;skills;skills training;social engagement;Social support;Social Workers;Speech;Spouses;Strategic Planning;Stress;stressor;Structure;success;Surveys;symposium;symptom management;Symptoms;Testing;therapy development;Training;Training Programs;Trauma;treatment as usual;United States National Institutes of Health;Work

PROJECT_TITLE: Resilient Together for Dementia: A live video resiliency dyadic intervention for persons with dementia and their care-partners early afterdiagnosis

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Traumatic brain injury (TBI) is a leading cause of death in the US, and treatment options are limited—we lack methods to assess a patient’s risk of deterioration at admission. An improved ability to classify patients early after injury will allow us to identify those who may benefit from aggressive interventions versus those who can safely be observed. The goal of the proposed project is to develop and assess a series of predictive models incorporating immune proteins from peripheral blood to aid in the prediction of which patients are at low-risk for complications and poor outcome after TBI.

PI_NAMEs: HINSON, HOLLY ELAINE (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Abbreviations;Accounting;Acute;Acute Brain Injuries;Admission activity;Age;analog;Benign;biomarker signature;Blood;Blood Vessels;blood-based biomarker;Brain Injuries;Cause of Death;Cell Adhesion Molecules;Classification;Clinical;Clinical Data;clinical phenotype;Clinical Research;clinical risk;clinical translation;Clinical Trials;clinically actionable;cohort;Complement;Complex;cytokine;Data;Deterioration;Development;digital;disease model;effective therapy;Enrollment;Event;Exclusion Criteria;Glasgow Outcome Scale;Goals;Head;Health;Heterogeneity;high dimensionality;Holly;Hospitals;Hour;Image;Immune;Immune response;immunoregulation;improved;inclusion criteria;Injury;innovation;insight;Interleukin-6;Intervention;Intracranial Hemorrhages;Ion Transport;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measurable;Measures;Mediator;Mentors;Metabolism;Methods;Modeling;Molecular;mortality;multidisciplinary;Nervous System Trauma;Neurologic;Neurologist;novel;Oregon;Outcome;Outcome Measure;Patient Care;patient oriented research;Patient risk;Patient Selection;patient stratification;Patients;Peripheral;peripheral blood;Phenotype;placebo group;Population;predictive modeling;programs;prospective;Proteins;proteomic signature;Proteomics;Randomized Controlled Clinical Trials;Research Project Grants;response;Risk;risk stratification;ROC Curve;Science;sensor;Series;Signaling Protein;single molecule;skills;Specific qualifier value;Structure;supervised learning;TBI treatment;Technology;Testing;Therapeutic Clinical Trial;Tranexamic Acid;Traumatic Brain Injury;Universities

PROJECT_TITLE: Predictors of Low-risk Phenotypes after Traumatic Brain Injury Incorporating Proteomic Biomarker Signatures.

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Public health relevance: This is project will develop and apply computational tools for analyzing large-scale data from genomic and complex disease studies to gain understanding the molecular mechanisms of complex diseases, Additionally, this project will develop novel risk prediction models to advance preventive medicine for complex diseases. Finally, the project will develop computational tools to aid improving reproducibility of biomedical research. All three aspects are fundamental in complex disease studies, where the knowledge will eventually lead to new and reliable treatment strategies.

PI_NAMEs: WEN, XIAOQUAN  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Biological;Biomedical Research;Communities;Complex;Computer software;computerized tools;Computing Methodologies;Data;Disease;Etiology;experimental study;genomic data;Genomics;improved;Investigation;Knowledge;large scale data;Medical;Methodology;Molecular;novel;Phenotype;Preventive Medicine;Process;public health relevance;randomized trial;Reproducibility;Research;risk prediction;risk prediction model;Scientist;Technology;treatment strategy;user-friendly

PROJECT_TITLE: Resolving Methodological Challenges in Genomics Research: Causality, Risk Prediction, and Reproducibility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative: Insulin degrading enzyme (IDE) is postulated to use large-scale motions between the N- and C-terminal domains to selectively unfold amyloid peptides, leading to necessary stabilization of the catalytic cleft prior to substrate degradation. We will use integrative structural approaches to better understand the molecular basis of substrate recognition and regulation of IDE. The success of our studies will allow us to selectively modulate the degradation of amyloid b and glucose regulating hormones through the development of innovative IDE-based therapies.

PI_NAMEs: TANG, WEI-JEN  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Address;Affect;Agonist;Algorithms;Alzheimer's Disease;Amyloid beta-Protein;Amyloid Fibrils;amyloid peptide;Animal Model;Binding;Biochemical;Biological Assay;Blood Glucose;C-terminal;Catalysis;combat;conformational conversion;Coupled;Cryoelectron Microscopy;cytotoxic;Defect;design;Development;Diabetes Mellitus;Dimerization;Disease;Drug Targeting;Engineering;enzyme activity;Enzyme Inhibitor Drugs;Enzyme Kinetics;Enzymes;Equilibrium;Exhibits;Family;Fluorescence Resonance Energy Transfer;Foundations;Genetic Screening;Glucagon;Glucose;glucose tolerance;Goals;Grain;Hormones;Human;human disease;Hyperactivity;image processing;improved;innovation;insight;Insulin;insulin regulation;Insulinase;islet amyloid polypeptide;Knowledge;Link;Mechanics;member;Metalloproteases;Methods;millisecond;Modeling;Molecular;Molecular Conformation;Monitor;monomer;Motion;Mus;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;Peptide Hydrolases;Peptides;Physiological;Play;Process;Proteome;Regulation;Research;Roentgen Rays;Role;screening;simulation;single molecule;small molecule;Structure;success;Techniques;Time;time use;unfoldase;Work;Yeasts

PROJECT_TITLE: Integrative structural analysis of human insulin degrading enzyme

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Temperature is critical to all life activities and regulates biological processes at various levels. Cells not only detect temperature changes through their unique temperature-sensitive molecular machineries but also adapt with appropriate responses to maintain their inherent functions. Ability to create well-defined nanoarchitectures that can stimulate and detect these thermal interactions can lead to the development of powerful research tools to investigate basic biological processes and ultimately allow advanced therapeutics and diagnostic agents for treating diseases.

PI_NAMEs: HU, YONGJIE  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TITLE: Nanoscale Temperature Mapping and Thermal Regulation of Intracellular Dynamics


NIH_SPENDING_CATS: Muscular Dystrophy;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Excessive muscle contraction and trauma often result in acute muscle injury, triggering the need for cellular repair. Defects in muscle repair contribute to and exacerbate chronic disorders like muscular dystrophy. The proposed studies will lead to an improved understanding of the mechanisms regulating muscle resealing and rebuilding, helping to guide therapeutic strategies aimed at improving muscle repair capacity.

PI_NAMEs: DEMONBREUN, ALEXIS R.;MCNALLY, ELIZABETH M (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Actins;Acute;Annexin A6;Annexins;Area;Cell Differentiation process;cell motility;cell type;Cells;Chronic Disease;Cytoplasm;Defect;Dependence;Disease;DNA Sequence Alteration;Dominant-Negative Mutation;DYSF gene;Event;extracellular;Extracellular Matrix;F-Actin;Family member;Genetic;Genetic Diseases;Health;Homologous Gene;Hour;improved;injured;Injury;injury and repair;Membrane;migration;Molecular;Muscle;Muscle Contraction;Muscle function;muscle repair;Muscular Atrophy;Muscular Dystrophies;Myoblasts;novel;Outcome;Pharmacology;Phase;polymerization;Polymers;Process;progenitor;programs;Proliferating;Proteins;recruit;repaired;Research;Resolution;Role;Sarcolemma;Sarcomeres;seal;Shoulder;Site;stem cell differentiation;Therapeutic;Time;tool;Trauma;Visualization;Work

PROJECT_TITLE: Mechanisms of resealing and rebuilding in muscle repair

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;Prevention;Substance Misuse

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative The proposed research is relevant to public health because substance use disorders (such as opioids, tobacco, and alcohol) are common, costly, and contribute to poor health outcomes. We are proposing the development of a method that helps researchers identify individuals with complex variations of these disorders in large data sets linked to genetic data in hopes of finding novel prevention and treatment interventions. The proposal is relevant to the National Institute on Drug Abuse’s emphasis on “…supporting and conducting basic and clinical research on drug use…and the underlying neurobiological…mechanisms involved.”

PI_NAMEs: JEFFERY, ALVIN DEAN (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Acceleration;Alcohols;Basic Science;Biological;clinical care;Clinical Decision Support Systems;Clinical Research;Code;Complex;Computer software;cost;Data;Data Sources;Development;Disease;Disease Management;disorder prevention;Drug usage;Electronic Health Record;Genetic;Genetic study;Goals;graphical user interface;heuristics;Individual;innovation;Intervention;Knowledge;Label;large datasets;Link;Methods;National Institute of Drug Abuse;Neurobiology;novel;Opioid;Outcome;Pharmaceutical Preparations;Phenotype;polygenic risk score;poor health outcome;portability;Prevention;preventive intervention;prospective;Public Health;Research;Research Personnel;Services;Specific qualifier value;Substance Use Disorder;substance use treatment;System;Text;Tobacco;Variant;Work

PROJECT_TITLE: Framework to Accelerate Substance Use Disorder Genetic Studies through Customizable, EHR-Based Precision Phenotyping


ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: OVERALL PROJECT NARRATIVE IDENTIFYING METABOLIC VULNERABILITIES IN LUNG CANCER Lung cancer is the leading cause of cancer deaths worldwide, and common therapy for both NSCLC and SCLC includes surgery, radiation, chemotherapy, and immunotherapy. Many of the driver genes mutated in lung cancer are transcription factors and are difficult to target therapeutically and have been dubbed “undruggable”. Our goal in this application is to develop a deep molecular understanding of the metabolic pathways regulated by key drivers in lung cancer using sophisticated and novel mouse models of lung cancer, patient derived samples and organoids, and state-of-the-art approaches in the analysis of metabolites to identify metabolic vulnerabilities in lung cancer as potential therapeutic targets.

PI_NAMEs: FLORES, ELSA R (contact);HAURA, ERIC B.

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Biology;Brassicaceae;Cancer Center;Cancer Etiology;Cancer Patient;Cell Line;Cells;Cessation of life;chemotherapy;Collaborations;Country;Cysteine;Cysteine Metabolism Pathway;Data;data repository;Data Science Core;Development;Disease;Doctor of Philosophy;Drug resistance;endoplasmic reticulum stress;Ensure;experimental study;Family;Florida;Genes;genetic signature;Genotype;Goals;Immune;Immunosuppression;Immunotherapy;in vivo evaluation;innovation;Knowledge;machine learning algorithm;Maintenance;Malignant neoplasm of lung;Manuscripts;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;Molecular;Molecular Profiling;mouse model;Mutate;Myeloid-derived suppressor cells;neoplastic cell;Newly Diagnosed;novel;Operative Surgical Procedures;Organoids;Pathogenesis;Pathology;patient subsets;Patients;PERK kinase;pre-clinical;Pre-Clinical Model;Prognosis;Program Research Project Grants;programs;Proliferating;Radiation;Regulation;Research;Resource Sharing;Sampling;Signal Transduction;small cell lung carcinoma;Survival Rate;synergism;targeted treatment;Therapeutic;therapeutic target;therapeutically effective;Tissue Microarray;TP53 gene;transcription factor;tumor;tumor microenvironment;Tyrosine Kinase Inhibitor

PROJECT_TITLE: Identifying Metabolic Vulnerabilities in Lung Cancer