ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Overall Narrative Kidney cancer is expected to be diagnosed in over 75,000 individuals in the US in 2021 and is particularly prevalent in Texas. Approximately 30% of patients develop metastatic disease, and 5-year survival rates are 12%. To address this unmet medical need, the UT Southwestern Medical Center Kidney Cancer SPORE has developed a comprehensive program to explore and translate therapeutic opportunities with established and new treatment approaches.

PI_NAMEs: BRUGAROLAS, JAMES  (contact);KAPUR, PAYAL

PROGRAM_OFFICER_NAME: SCROGGINS, BRADLEY TODD

PROJECT_TERMS: Accounting;Address;angiogenesis;Angiogenesis Inhibitors;anti-cancer research;Antigen Presentation;Area;arm;Bioinformatics;Biological Markers;Biotechnology;Bypass;Carbon;career;Cell Proliferation;Cell Survival;Cessation of life;Chemicals;Citric Acid Cycle;Clear Cell;Clear cell renal cell carcinoma;clinical practice;Collaborations;Comprehensive Cancer Center;Computerized Medical Record;Conventional (Clear Cell) Renal Cell Carcinoma;Core Facility;Data Analytics;data management;Death Rate;Dependence;Development;Diagnosis;Disease;Drug Screening;Education;Enzymes;Evaluation;Failure;Foundations;Funding;Generations;Genes;Genomics;Germ-Line Mutation;Glutaminase;Glutamine;Glycogen;Growth;Heart failure;Hypertension;Image;Immune checkpoint inhibitor;Immune system;immunogenic;Immunotherapy;In complete remission;in vivo;Individual;Inflammation;Infusion procedures;inhibitor;Innate Immune System;innovation;International;Isotope Labeling;KDR gene;Link;Lipids;Medical;Medical center;Metabolic;Metabolism;Modeling;mutant;Nitrogen;Nivolumab;novel therapeutic intervention;novel therapeutics;Nutrient;palliative;Pathology;Pathway interactions;Patient Care;patient population;Patients;Pharmaceutical Preparations;Pharmacologic Substance;phase I trial;Phenotype;Phosphotransferases;Physiological;predictive marker;Prize;Process;Production;programs;Proteinuria;Radiation;radiotracer;real time monitoring;Recording of previous events;Renal Carcinoma;Renal Cell Carcinoma;Research;Research Personnel;Resistance;resistance mutation;safety and feasibility;Sagittaria;side effect;Small Interfering RNA;stemness;STING agonists;Structure;success;Survival Rate;targeted treatment;Technology;Texas;Therapeutic;tool;Toxic effect;Tracer;transcription factor;Translating;Translations;tumor;Tumor Bank;Tumor Promotion;tumorigenesis;Tyrosine Kinase Inhibitor;Universities;Update;Vascular Endothelial Growth Factors;VHL mutation

PROJECT_TITLE: University of Texas Southwestern Medical Center SPORE in Kidney Cancer


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: To increase the pathways for URM students to reach graduate biomedical training, Bridges-UAB will initially focus on the transition and initial biomedical education of students into Jefferson State Community College (JSCC) and then the transition to rigorous laboratory research and training at the University of Alabama at Birmingham (UAB). Bridges-UAB will offer 10 JSCC students each year the opportunity to pursue biomedical and behavioral research under the tutelage of world-class, funded researchers and educators, so that working in research teams, the students will conduct discovery research that they design in concert with their research mentor, thus advancing their research skills and knowledge of biomedical and behavioral sciences and helping them to decide a direction for their careers. In addition to the research mentors, more senior Bridges-UAB students and graduate students will serve as peer mentors to ensure that Bridges-UAB students have a smooth transition into biomedical courses at JSCC, into successful research at UAB and career success.

PI_NAMEs: KIN, NICHOLAS W.;WYSS, J. MICHAEL (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Address;Alabama;Behavioral;Behavioral Research;Behavioral Sciences;Biomedical Research;bridge to the baccalaureate;career;community college;cost;Doctor of Philosophy;Education;Educational workshop;Funding;Graduate Education;Grant;Internships;Knowledge;Learning;Mentors;Methods;Minority;minority student;National Institute of General Medical Sciences;peer coaching;Population;programs;recruit;Research;Research Training;Scholarship;Schools;skills;Students;success;summer research;Time;Training Programs;undergraduate student;United States National Institutes of Health;Universities;university student;Work

PROJECT_TITLE: Bridges to the Baccalaureate Research Training Program at University of Alabama at Birmingham

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Kidney Disease;Orphan Drug;Rare Diseases

ORG_STATE: TX

PHR: Project Narrative Having identified the first core dependency in kidney cancer and having developed a drug now approved by the FDA, we propose to develop a second-generation drug able to target resistant tumors along with a highly innovative radiology test enabling visualization of target engagement in patients.

PI_NAMEs: BRUGAROLAS, JAMES  (contact)

PROJECT_TERMS: Affinity;analog;Binding;Biological Markers;biomarker identification;Biopsy;Biotechnology;cancer type;Chemicals;Chemistry;Clear cell renal cell carcinoma;Clinical;Clinical Trials;cohort;Collaborations;Data;Dependence;Dissociation;DNA Binding;Dose Limiting;dosimetry;Down-Regulation;Drug resistance;Drug Targeting;Evaluation;experimental study;FDA approved;Fluorine;Funding;Future;Generations;Genes;Genetic Transcription;HIF1A gene;Human;Hypoxia Inducible Factor;imaging biomarker;Imaging Device;implantation;in vivo;inhibitor;innovation;Institutional Review Boards;Integrin alphaVbeta3;Ligands;Malignant Neoplasms;manufacture;Measurable;Measures;Mediating;Medical center;Messenger RNA;Modeling;molecular imaging;Monitor;mRNA Transcript Degradation;Mus;mutant;Mutation;Nature;Neoplasm Transplantation;novel;novel therapeutics;Oncology;Patients;Pharmaceutical Preparations;Pharmacologic Substance;phase 1 study;Phase I Clinical Trials;phase I trial;Positron-Emission Tomography;pre-clinical;programs;Proteins;radioligand;Radiology Specialty;radiotracer;Renal Carcinoma;Renal Cell Carcinoma;Reporting;Resistance;Resistance development;resistance mutation;RNA Interference;Sagittaria;Small Interfering RNA;small molecule inhibitor;Specificity;standard of care;success;Testing;Texas;Therapeutic;therapeutic siRNA;Toxic effect;transcriptome sequencing;Transplantation;tumor;tumor growth;Universities;Visualization;Work

PROJECT_TITLE: Project 1: Targeting HIF2 in Renal Cell Carcinoma


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease

PROJECT_TERMS: Advocacy;Advocate;anti-cancer research;Automobile Driving;Award;Cancer Center;Cancer Patient;Cancer Research Project;Cancer Survivor;career;Caregivers;Caring;Clinic;Clinical;Common Neoplasm;Communication;Communities;Complex;Comprehensive Cancer Center;Core Facility;Country;County Hospitals;data management;Development;Education;equity, diversity, and inclusion;Event;experience;Faculty;Faculty Recruitment;Fostering;Foundations;Funding;Future;Goals;Health Resources;Healthcare;Hospitals;Incidence;innovation;Institution;Interdisciplinary Study;Kidney;Leadership;Malignant Neoplasms;Medical center;Mission;Monitor;multidisciplinary;Office of Administrative Management;Organizational Objectives;Patient advocacy;patient population;Patients;Program Evaluation;programs;recruit;Renal Carcinoma;Reporting;Research;Research Personnel;Resource Allocation;Role;role model;Services;sound;Structure;success;synergism;Texas;Translating;Underrepresented Minority;Universities;volunteer

PROJECT_TITLE: Core A: Administrative Core


ADMINISTERING_IC: MD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: Springfield

ORG_NAME: OREGON RES BEHAVIORAL INTERVENTION STRAT

ORG_STATE: OR

PHR: PROJECT NARRATIVE Most of the over 32.7 million people in the U.S. who have special health, developmental, and mental health concerns have typically developing (TD) brothers and sisters who share high levels of involvement in their sibling’s lives. Disability and health agencies lack effective tools to support the information and support needs of TD siblings and their families, in particular for ethnic minority and rural families. The aims of this proposal are to complete development and evaluation of the dual language SIBTime app, designed to build parents’ and children’s knowledge, skills, and engaging family routines to nurture TD siblings’ (ages 3-6) social-emotional health and well-being.

PI_NAMEs: MARQUEZ, JESSIE  (contact);METZLER, CAROL W;VADASY, PATRICIA F

PROGRAM_OFFICER_NAME: BURNS, PAUL ANTHONY

PROJECT_TERMS: Address;affection;Age;Animals;animation;Area;Attention;Behavioral;behavioral health;bilingualism;Brothers;Caregivers;caregiving;Child;Child Rearing;Childhood;Communication;Control Groups;Data;design;Development;disability;Disabled Persons;Early Intervention;Educational workshop;efficacy testing;Emotional;Emotions;Enhancement Technology;ethnic diversity;ethnic minority;Evaluation;Exercise;experience;Face;Family;Family Relationship;family support;Feedback;Feeling;Focus Groups;Frequencies;Friends;Future;Geography;Government;Guilt;hands-on learning;Health;human old age (65+);Impaired health;improved;Incidence;Individual;interactive tool;Internet;Intervention;Knowledge;Language;Learning;life span;Measures;Mental Health;Minority;mobile application;Multimedia;Narration;next generation;Nursery Schools;Outcome Assessment;Parent-Child Relations;Parents;Participant;peer;Personal Satisfaction;Persons;Phase;Pilot Projects;pilot test;Play;post intervention;pressure;programs;prototype;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Personnel;response;Risk;Role;Rural;rural families;Sample Size;satisfaction;scaffold;School-Age Population;Self Efficacy;service providers;Siblings;Sister;skills;social;socioeconomics;Spanish/English;Special needs;stressor;support tools;System;Technology;Testing;Thinking;Time;tool;Training;United States;usability;Visual;Waiting Lists;web app

PROJECT_TITLE: SIBTime: Media-enhanced Technology for Promoting the Behavioral Health and Family Relationships of Typically Developing Young Siblings


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Orphan Drug;Rare Diseases

PHR: Project Narrative Clear cell renal cell carcinoma (ccRCC) is characterized by altered metabolic pathways that promote tumor growth but may render the tumors susceptible to metabolic inhibitors. In this Project, we will apply our discoveries of metabolic pathways that promote ccRCC progression and metastasis in patients to test whether inhibiting these pathways with novel metabolic inhibitors suppresses tumor growth in a panel of human-derived ccRCC tumors growing in mice. Further, we will test the impact of these inhibitors on both the tumor cells and immune cells in the tumor microenvironment (TME) in novel syngeneic models of kidney cancer in immunocompetent mice.

PI_NAMEs: DEBERARDINIS, RALPH J (contact)

PROJECT_TERMS: Address;Bypass;Carbon;Cathepsins;Cell Physiology;cell type;Cells;Citric Acid Cycle;Clear Cell;Clear cell renal cell carcinoma;Clinic;Collaborations;Cytotoxic T-Lymphocytes;Data;Dependence;drug development;Drug Targeting;Enzymes;Equilibrium;Event;Failure;Generations;genetic approach;Germ-Line Mutation;Glucose;Glutaminase;Glutamine;Glycogen;Growth;Human;Immune;Immunocompetent;Implant;in vivo;Infusion procedures;inhibitor;innovation;insight;Intervention;Knowledge;Label;Link;Lipids;Malignant Neoplasms;Mediating;Medical center;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Modeling;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;next generation;Nitrogen;nitrogen metabolism;Non-Malignant;novel;novel strategies;Nutrient;oxidation;Oxidation-Reduction;Oxidative Phosphorylation Deficiency;Pathway interactions;Patients;Pharmacologic Substance;Phenotype;Predisposition;Process;Reaction;Renal Carcinoma;Renal Cell Carcinoma;Reporting;Resistance;Role;small molecule;Source;Testing;Texas;Therapeutic;therapeutic target;Translating;treatment response;tumor;tumor growth;tumor metabolism;tumor microenvironment;Tumor Promotion;Tumor Tissue;tumorigenesis;Universities

PROJECT_TITLE: Project 2: Defining Targetable Metabolic Dependencies in Human Renal Cell Carcinoma


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases

PHR: Project Narrative Immune checkpoint inhibitor combinations have shown considerable promise, but the majority of metastatic kidney cancer patients are not cured. We propose to engage both the innate and the adaptive immune system arms to improve the outcome of immune checkpoint inhibitors for patients with metastatic kidney cancer.

PI_NAMEs: HANNAN, RAQUIBUL  (contact)

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;analog;anti-PD-L1;Antigen Presentation;arm;Biological Availability;Biological Sciences;Biopsy;Blood specimen;Cancer Patient;Clinical;Clinical Trials;Cytosol;design;Development;DNA;Dose Limiting;experience;Future;Gene Expression;Goals;Immune;Immune checkpoint inhibitor;Immune system;immunogenic cell death;Immunotherapy;improved;improved outcome;In complete remission;Inflammation;innate immune sensing;Innate Immune System;innovation;insight;Interferons;Intervention;ipilimumab;Label;Ligands;Maintenance;Medical;Medical center;Metastatic Renal Cell Cancer;molecular imaging;Natural Immunity;Neoadjuvant Therapy;Nivolumab;novel;Pathway interactions;patient population;Patients;Pharmacodynamics;Phase;phase I trial;Phase II Clinical Trials;phase II trial;Physiological;Positioning Attribute;Positron-Emission Tomography;Prize;Production;programmed cell death ligand 1;programs;Progressive Disease;Radiation;radiotracer;Randomized;Regimen;Renal Carcinoma;Renal Cell Carcinoma;Research;response;Safety;Second Messenger Systems;Site;Stable Disease;standard of care;Stimulator of Interferon Genes;STING agonists;success;Survival Rate;Texas;Therapeutic Intervention;Tissue Sample;Tissues;tool;Toxic effect;trial comparing;tumor;Universities;Work

PROJECT_TITLE: Project 3: Maximizing Anti-tumor Activity through Simultaneous Activation of the Innate and Adaptive Immune System in Kidney Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Kidney Disease;Orphan Drug;Precision Medicine;Rare Diseases

PHR: Project Narrative All of the proposed SPORE projects are dependent on the pathology and tissue resources provided by the Biospecimen and Pathology Resources Core (Core B). The Core B Director is a pathologist with histomorphologic and research expertise in adult kidney cancers, and with extensive experience in biobanking. The proposed Core infrastructure will further strengthen our ongoing translational mission and has the potential to revolutionize personalized medicine in renal cancer.

PI_NAMEs: KAPUR, PAYAL  (contact)

PROJECT_TERMS: Academia;Address;Adult;Advisory Committees;Animal Model;assay development;Basic Science;Benchmarking;biobank;Biological Assay;Biological Specimen Banks;Black race;Blood;BRAF gene;brca gene;Cancer Biology;cancer cell;Cell Culture Techniques;Cell Line;CLIA certified;Clinic;Clinical;Clinical Data;clinical practice;Clinical Trials;cohort;Collaborations;Communication;Communities;Comprehensive Cancer Center;Cryopreserved Tissue;Dana-Farber Cancer Institute;Data;Development;digital pathology;Dimethyl Sulfoxide;DNA;DNA copy number;drug sensitivity;drug testing;ethnic diversity;Evaluation;exome sequencing;experience;FDA approved;federated learning;Fostering;Freezing;Gene Expression;Generations;Genetic;Genitourinary system;Genomics;Goals;Hispanic;Histologic;Histology;Human;human model;Image Analysis;Immunoassay;Immunohistochemistry;Implant;improved;In Situ Hybridization;in vivo;Industry;Infrastructure;innovation;Institution;interdisciplinary approach;Journals;Kidney;Kidney Neoplasms;knockout animal;Laboratories;laser capture microdissection;Letters;Link;Malignant Neoplasms;Medical center;member;Metabolic;Metabolism;Modeling;Molecular;Mus;Mutation;National Cancer Institute;National Comprehensive Cancer Network;Nature;Neoplasm Metastasis;Nutrient;Oncology;Paraffin Embedding;Pathologic;Pathologist;Pathology;Pathway interactions;Patient Care;patient derived xenograft model;Patients;personalized diagnostics;personalized medicine;Pharmaceutical Preparations;pre-clinical;precision medicine;preservation;Primary Neoplasm;Principal Investigator;programmed cell death ligand 1;programs;Protocols documentation;Publishing;Quality Control;racial diversity;Radiation;radiotracer;rare condition;rare variant;Renal Carcinoma;Renal Cell Carcinoma;Renal Mass;repository;Research;Research Personnel;Resources;RNA;Sampling;Services;Small Interfering RNA;SNP array;Specimen;Stable Isotope Labeling;Standardization;stem;Stimulator of Interferon Genes;Testing;Texas;Therapeutic;Tissue Banks;Tissue Microarray;Tissue Preservation;tissue processing;Tissue Procurements;tissue resource;Tissues;Tracer;transcriptome sequencing;Transgenic Organisms;translational goal;Translational Research;Tropism;tumor;Tumor Bank;Tumor Cell Line;Tumor Markers;Universities;Validation;whole slide imaging

PROJECT_TITLE: Core B: Biospecimen and Pathology Resources Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Kidney Disease;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative The Data Analytics Core will provide biostatistics, bioinformatics, and data management support to all three SPORE projects, the CEP and DRP, as well as to the SPORE Cores. The Core will ensure that the appropriate statistical design is incorporated into all studies from inception, that the data are properly analyzed using the state-of-the-art data methods, and that all results are interpreted on statistical as well as biological significance. The Core also supports the SPORE through a state-of-the-art data management platform.

PI_NAMEs: AHN, CHUL W (contact)

PROJECT_TERMS: anti-cancer research;biobank;Bioinformatics;Biological;Biological Markers;Biometry;Biostatistics Shared Resource;cancer cell;career;Cell Line;Cells;Clinical;Clinical Data;Clinical Oncology;Collection;Communication;Communities;Complex;Comprehensive Cancer Center;Computerized Medical Record;Computing Methodologies;Core Facility;Data;Data Analyses;Data Analytics;data integration;data management;Data Science;Data Set;Database Management Systems;design;Development;Ensure;experience;Experimental Designs;Faculty;Funding;Genomics;Immune;Immunology;Individual;innovation;Journals;Kidney;Kidney Neoplasms;Lead;Link;Malignant Neoplasms;Manuscripts;Medical center;member;metabolomics;Methodology;Methods;mid-career faculty;Modeling;Nature;Neoplasm Metastasis;novel;Patients;Population Sciences;professor;programs;Publications;Publishing;Renal Carcinoma;Reporting;Reproducibility;Research;Research Activity;Research Design;Research Personnel;Resources;Sampling;Science;sound;Statistical Data Interpretation;success;Texas;Tissue Banks;tool;transcriptome sequencing;Translations;tumor;Universities;Update;Visualization;web-accessible;Work

PROJECT_TITLE: Core C: Data Analytics Core


ADMINISTERING_IC: HL

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Heart Disease;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Physical Activity;Prevention;Skin Cancer;Social Determinants of Health;Telehealth

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: This mid-career development award is designed to support mentoring in digital health research for cardiovascular disease prevention that leverages the resources of the UConn Center for mHealth and a transdisciplinary co-mentoring team. The Candidate's training model will equip mentees with: research methodology skills, knowledge of the “idea to market” process, opportunities to collect preliminary data, grant/manuscript writing experience, professional development, training in the ethical conduct of research, and “hands on” team science experience.

PI_NAMEs: PAGOTO, SHERRY L. (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: acceptability and feasibility;active lifestyle;Adult;adult obesity;Affect;Ally;American;Authorship;behavior change;Behavior Therapy;Behavioral;Behavioral Sciences;Blood Pressure Monitors;Body Weight decreased;cancer prevention;Cardiology;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cause of Death;Clinic;Collaborations;cost effectiveness;Data;Data Analyses;Data Science;design;Development;Diabetes Mellitus;diabetes prevention program;Diet;diet and exercise;Dietitian;digital health;Disease;efficacy testing;Environment;Ethics;Exercise;experience;Facebook;Facebook delivery;Faculty;Family;Family member;feasibility testing;feasibility trial;First Degree Relative;Funding;Goals;good diet;Grant;Health;Health behavior;health care economics;Health Professional;healthy lifestyle;healthy weight;high school;Hypertension;Image;Incidence;innovation;innovative technologies;Intervention;K-Series Research Career Programs;Knowledge;Laboratories;Learning;Life;lifestyle factors;lifestyle intervention;Lipids;Malignant Neoplasms;Manuscripts;Marketing;medical schools;Melanoma;Mentors;Mentorship;Methodology;mHealth;Misinformation;mobile application;Modeling;Monitor;multiphase optimization strategy;next generation;nicotine use;Obesity;Outcome;Paper;Participant;patient engagement;Patients;Physical activity;Population;Prevention;Prevention program;Preventive;preventive intervention;Privatization;Problem Solving;Process;programs;Public Health;Public Health Informatics;public health priorities;Randomized;Randomized, Controlled Trials;recruit;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk Factors;Risk Reduction;Role;Science;sedentary lifestyle;skills;skin cancer prevention;social media;Social Network;social network intervention;social networking website;Stress;Survivors;Technology;Testing;Text;Tobacco;tool;Training;Translating;trial design;Triglycerides;Twitter;United States National Institutes of Health;Universities;Visit;Weight;weight loss intervention;Weight maintenance regimen;Work;Writing;young adult;young woman

PROJECT_TITLE: Mentoring in mHealth and Social Networking Interventions for CVD Risk Reduction

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Aging is a universal cancer risk factor, highlighting the urgent need to identify molecular mechanisms that increase cancer incidence and aggressiveness in the elderly. While the immune system can suppress the growth of a developing tumor, CD8+ T cells are particularly vulnerable to age-related functional decline and surprisingly little is known about the impact of aging on anti-tumor immunity. This study seeks to define causal molecular and metabolic adaptations within T cells in the aging tumor microenvironment that mediate tumor progression, with the goal of revealing new pathways that may be targeted to improve cancer therapy and prevention.

PI_NAMEs: RINGEL, ALISON EPSTEIN (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Affect;Age;age effect;age related;age related changes;aged;Aging;anti-cancer research;Applications Grants;Atlases;Bacterial Infections;Beds;Bioenergetics;Biological Models;Black Box;cancer cell;cancer diagnosis;Cancer Model;cancer prevention;Cancer Research Project;cancer risk;cancer therapy;career;CD8-Positive T-Lymphocytes;cell age;Cell Culture Techniques;cell killing;Cell Physiology;cell type;Cells;comparative;Data;Dedications;Development Plans;diet-induced obesity;Doctor of Philosophy;Elderly;environment related cancer;Environmental Impact;Environmental Risk Factor;Enzymes;Faculty;Fatty acid glycerol esters;Flow Cytometry;functional decline;Functional disorder;Future;Genes;Genetic Transcription;Goals;Growth;healthy aging;Heterogeneity;human old age (65+);Immune;immune function;Immune response;Immune system;Impairment;improved;In Vitro;in vivo;Incidence;Infiltration;innovation;insight;Interview;Laboratories;Lead;Life Expectancy;Link;lipid biosynthesis;lipid mediator;lipidomics;Lipids;Malignant Neoplasms;Manuscripts;Maps;Measures;Mediating;medical schools;Mentors;Metabolic;Metabolic Pathway;metabolomics;Modeling;Molecular;mouse model;Mus;Mutation;neoplastic cell;Newly Diagnosed;Normal tissue morphology;Obese Mice;Obesity;old mice;overexpression;Pathway interactions;patient population;Patients;Physiology;Population;Positioning Attribute;Postdoctoral Fellow;pre-clinical;Predisposition;Prevention therapy;Process;programs;Publishing;Research;Research Proposals;response;Risk Factors;Role;single-cell RNA sequencing;Stress;Stromal Cells;Systems Biology;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;tenure track;Testing;Therapeutic;Time;transcriptomics;tumor;tumor growth;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Virus Diseases;Work;young adult

PROJECT_TITLE: Cellular and microenvironmental mechanisms linking aging to tumor control


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases

PHR: Project Narrative The Translational Imaging Core (TIC) will offer novel quantitative magnetic resonance imaging (MRI) techniques and Positron Emission Tomography (PET) with a variety of novel radiotracers to SPORE investigators for the noninvasive characterization of renal cell carcinoma in animal models and patients and for the assessment of the response to therapies. A sophisticated radiogenomics platform to co-register MRI and PET/CT images with tumor specimens will allow targeted tissue procurement informed by imaging features detected in vivo. The TIC will provide a web-based centralized archive and image analysis capabilities for all imaging data acquired in SPORE projects.

PI_NAMEs: PEDROSA, IVAN  (contact)

PROJECT_TERMS: 3D Print;angiogenesis;Animal Model;anti-PD-L1 antibodies;Antibodies;Archives;Area;Binding;career;Chemicals;Clear cell renal cell carcinoma;clinical development;Clinical Trials;Combination immunotherapy;Data;Development;dosimetry;empowerment;Ensure;Evaluation;experimental study;feature detection;Food and Drug Administration Drug Approval;gene discovery;Generations;Glutamine;Goals;Growth;Heterogeneity;Histologic;Human Resources;Image;Image Analysis;image archival system;image translation;imaging biomarker;imaging modality;Imaging Techniques;immune checkpoint;Immune system;ImmunoPET;in vivo;inhibitor;innovation;Institutional Review Boards;Intervention;Investigational Drugs;Label;Magnetic Resonance Imaging;Medical center;Metabolic;Metabolism;Metastatic Renal Cell Cancer;Methodology;Methods;Molds;Monitor;mutant;neoplastic cell;non-invasive monitor;novel;novel therapeutic intervention;Nutrient;Oncogenic;Online Systems;Pathway interactions;Patient imaging;Patients;PD-1/PD-L1;Pharmaceutical Preparations;Pharmacologic Substance;Play;Positron-Emission Tomography;pre-clinical;preclinical development;preclinical imaging;programmed cell death ligand 1;programs;Proteins;Protocols documentation;Radiogenomics;Radiology Specialty;radiomics;radiotracer;real time monitoring;Regimen;Renal Carcinoma;Renal Cell Carcinoma;Research;Research Personnel;Role;Services;Specimen;Technology;Testing;Texas;Therapeutic;Time;Tissue Procurements;Tissue Sample;tool;translational goal;treatment response;tumor;tumor heterogeneity;tumor metabolism;United States Food and Drug Administration;Universities;uptake;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Core D: Translational Imaging Core


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE  The current design of neurosurgical residencies and changes to training priorities have imposed troublesome restrictions on our ability to foster and retain neurosurgeon-scientists. This proposal describes an innovative program to cultivate and maintain the interest and capability of neurosurgeon-scientists by providing newly formatted opportunities, mentorship, and continuity. Our residency has been specifically redesigned to recruit, train, and propel neurosurgeon-scientists into an NIH-funded academic career.

PI_NAMEs: FECCI, PETER  (contact);HASAN, DAVID M.

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Address;Award;Brain;burden of illness;Cancer Education Grant Program;career;career preparation;Clinical;clinical implementation;clinical practice;Coupled;design;Doctor of Philosophy;Education Projects;education research;Educational Curriculum;Educational process of instructing;Enrollment;Ensure;Environment;Equipment;experience;Faculty;faculty mentor;Failure;Financial Support;flexibility;Fostering;Funding;Goals;human disease;improved;innovation;interest;Leadership;Mentors;Mentorship;Minority;Modeling;Molds;National Institute of Neurological Disorders and Stroke;Neurosciences;Neurosurgeon;neurosurgery;novel strategies;Patients;Physicians;Population Scientist Supplement (R25);Positioning Attribute;Preparation;Productivity;programs;Records;recruit;Research;Research Methodology;Research Support;Residencies;Rewards;Scientist;Secure;Site;Specimen;Structure;success;Talents;Therapeutic;Thinking;Time;Training;Training Programs;Translating;Translations;United States National Institutes of Health;Wages

PROJECT_TITLE: NINDS Research Education Programs for Residents and Fellows in Neurosurgery


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease

PROJECT_TERMS: anti-cancer research;arm;Award;Budgets;Cancer Patient;cancer research center director;Cellular biology;Clinical;Clinical Trials;Collaborations;Comprehensive Cancer Center;Dedications;Development;Electronic Mail;Ethnic Population;experience;Faculty;Faculty Recruitment;Fostering;Foundations;Funding;Future;Grant;Hematology;high reward;Immune system;improved;improved outcome;innovation;Institution;interest;Internal Medicine;International;Kidney;Lead;Leadership;Letters;Medical center;meetings;member;Mentorship;mid-career faculty;Minority Groups;Mission;multidisciplinary;Nephrology;novel therapeutics;Oncology;Patient-Focused Outcomes;Peer Review;Physicians;Physiology;Preparation;professor;Program Research Project Grants;programs;Publications;Qualifying;racial population;recruit;Renal Carcinoma;Reproduction spores;Research;Research Personnel;Research Project Grants;research study;Resources;Scientific Advances and Accomplishments;Scientist;Selection Criteria;success;symposium;synergism;Texas;Translating;translational cancer research;translational impact;translational potential;Translational Research;Translations;trend;tumor;Underrepresented Minority;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Developmental Research Program


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Opioid Misuse and Addiction;Opioids;Patient Safety;Rehabilitation;Substance Misuse;Telehealth

ORG_CITY: ELIZABETHTOWN

ORG_NAME: BEHAVR, LLC

ORG_STATE: KY

PHR: Project Narrative Medications for opioid use disorder (MOUD) like buprenorphine are currently the most effective form of intervention for opioid use disorder (OUD); however, novel behavioral adjuncts are needed to remediate dysregulation in brain reward systems, enhance MOUD adherence, and prevent relapse. BehaVR, LLC will meet this need by translating an evidence-based biobehavioral treatment approach into an innovative digital therapeutic for OUD that will increase accessibility to services to improve the patient's chances of long-term treatment success.

PI_NAMEs: WEISBERG, RISA B (contact)

PROGRAM_OFFICER_NAME: ANGELONE, LEONARDO MARIA

PROJECT_TERMS: Abstinence;addiction;Adherence;Affect;Affective;affective neuroscience;American;Area Under Curve;arm;Back;barrier to care;Behavior Therapy;Behavioral;biobehavior;Biochemical;Biometry;Brain;Buprenorphine;chronic pain;Clinic;Clinical;clinical efficacy;Clinical Research;Cloud Computing;Cognitive;commercialization;Computerized Medical Record;COVID-19 pandemic;craving;cue reactivity;Data;design;Development;digital treatment;Dropout;Drug Modulation;Ecological momentary assessment;Educational Intervention;effective intervention;efficacy study;electronic data;Electronic Health Record;Environment;Epidemic;evidence base;experience;Fast Healthcare Interoperability Resources;Feedback;Funding;Goals;Health Services Accessibility;Human;Human Resources;implementation barriers;improved;Individual;Ingestion;innovation;Intervention;Light;Link;Machine Learning;Measures;Medical Device;medication for opioid use disorder;meetings;mindfulness;National Institute of Drug Abuse;neurophysiology;novel;Opioid;opioid epidemic;opioid misuse;opioid treatment program;opioid use;opioid use disorder;Outcome;Outcome Measure;Participant;patient engagement;patient safety;Patients;Persons;Pharmaceutical Preparations;Phase;phase 1 study;pilot test;Process;programs;promoter;Protocols documentation;prototype;Psychophysiology;Randomized, Controlled Trials;Records;Recovery;Regulatory Pathway;Relapse;relapse prevention;remediation;Research Design;Resources;response;reward processing;Rewards;Risk;Safety;satisfaction;Self Efficacy;Services;Signal Transduction;skills;Small Business Innovation Research Grant;Specific qualifier value;success;Sum;System;Techniques;Teleconferences;Testing;therapeutic development;Therapeutic Effect;therapy development;Training;Translating;treatment as usual;Treatment outcome;treatment program;treatment risk;treatment strategy;United States;United States Food and Drug Administration;usability;Viral;virtual;virtual machine;virtual reality;virtual reality system

PROJECT_TITLE: Digital Therapeutic Development of Virtual Cognitive-Affective Training for Opioid Use Disorder


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Health Services;Mental Health

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: ARISE NARRATIVE Mental disorders make an increasingly significant contribution to the burden of disease in African low- and middle-income countries, also increasing risk for a range of other health conditions and injuries, yet health systems are poorly resourced to address the problem. Although investment in mental health research capacity building in Africa has increased in recent years, disparities in these areas remain evident particularly in comparison to the substantial funding underpinning research and research training for infectious and other non- communicable diseases in the region. Thus, there is a need for mental health research capacity building in Africa, led by African public mental health researchers, to drive local research priorities and retain precious human resources on the continent.

PI_NAMEs: KAGEE, SHAHEEN ASHRAF;SORSDAHL, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Africa;African;Collaborations;Communicable Diseases;Communities;COVID-19 pandemic;Discipline;Disease;Distance Learning;Doctor of Philosophy;doctoral student;early-career faculty;Educational process of instructing;Enrollment;experience;Faculty;Funding;graduate student;Grant;Health Services Research;implementation research;Institution;Knowledge;life span;member;Mental Health;Mental Health Services;Mentors;Policy Maker;Policy Research;programs;Psychology;Public Health;Research;Research Personnel;response;routine care;skills;Supervision;Training;Universities;Work

PROJECT_TITLE: Program ARISE2: African mental health Researchers Inspired and Equipped

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(55)R]


PROJECT_TERMS: Address;anti-cancer research;Award;Budgets;career;career development;Cells;Cellular biology;Clinical;Clinical Investigator;Comprehensive Cancer Center;Core Facility;Data;design;Development;Development Plans;Direct Costs;Early Diagnosis;Education;Educational workshop;Electronic Mail;experience;Extramural Activities;Faculty;Female;Foundations;Funding;Funding Agency;Genitourinary system;Goals;Grant;innovation;Institution;interest;International;Kidney;Leadership;Manuscripts;Medical center;meetings;member;Mentors;Mentorship;mid-career faculty;Minority Groups;minority scientist;Mission;Molecular;next generation;novel;outreach;Pathologist;Pathology;Preparation;Prevention;professor;programs;Publications;Qualifying;recruit;Renal Carcinoma;Reproduction spores;Research;Research Personnel;research study;role model;Scientist;Seasons;Selection Criteria;skills;success;symposium;synergism;Talents;Texas;Training;translational cancer research;translational potential;Underrepresented Minority;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Career Enhancement Program


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Cancer;Natural Products

ORG_CITY: HANOVER

ORG_DEPT: CHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE  Discoveries in cross-disciplinary fields related to organic chemistry relies in part on efficient access to heterocyclic compounds with novel molecular structures. This project will result in the invention of new chemical reactions and a deeper understanding of the underlying principles that govern these processes, thus facilitating the synthesis of natural products and synthetic compounds of high translational value.

PI_NAMEs: WU, JIMMY  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Novel Dearomative Indole Annulation Reactions, Beckmann Fragmentations, and Their Applications to Synthesis

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Building on long-standing expertise of this lab on TGFβ signaling in development, regeneration and cancer, this project will elucidate how TGFβ regulates epithelial phenotypic plasticity in concert with intra-tumoral fibrosis to promote tumor invasion and metastasis, and how TGFβ stimulates entry of metastasis-initiating into quiescent, immune-evasive states that support their survival as residual disease. This work will increase our understanding of how to target TGFβ in order to suppress metastatic relapse and resistance to therapy. 1

PI_NAMEs: MASSAGUE, JOAN  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: cancer cell;Cells;Coupled;Development;embryonic stem cell;Epigenetic Process;Epithelial Cells;Epithelium;Event;Experimental Models;Exposure to;fibrogenesis;Fibrosis;Genes;Goals;Growth;Homeostasis;Human;Immune Evasion;Immunotherapy;Knowledge;Link;Lung Adenocarcinoma;Malignant Neoplasms;Mediating;Mesenchymal;Natural regeneration;Nature;Neoplasm Metastasis;neoplastic cell;Normal Cell;Organ;Pancreatic Ductal Adenocarcinoma;Phenotype;Regulation;Relapse;Residual Neoplasm;Resistance;Role;Signal Pathway;Signal Transduction;Signal Transduction Pathway;stem;stem cells;therapy resistant;Tissues;transcription factor;Transforming Growth Factor beta;tumor;Tumor Biology;Tumor Cell Invasion;tumor growth;Tumor Promotion;Tumor Suppression;tumorigenesis;Work

PROJECT_TITLE: The TGFÃÂÃÂÃÂÃÂ² Signaling Pathway in Development and Cancer


NIH_SPENDING_CATS: Brain Disorders;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative The translocation of proteins across membranes is a fundamental process involved in the biosynthesis and degradation of a large class of proteins. The medical importance of translocation is demonstrated by the large number of diseases, including cystic fibrosis and α1-antitrypsin deficiency, which result from the misfolding of ER proteins and their subsequent degradation in the cytosol, as well as by peroxisomal disorders, such as Zellweger syndrome. A better understanding of the translocation processes may elucidate the causes of these diseases and result in the development of drugs that allow selective interference.

PI_NAMEs: RAPOPORT, TOM A (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 26S proteasome;Address;alpha 1-Antitrypsin Deficiency;Anabolism;aqueous;ATP phosphohydrolase;Back;Binding;Biogenesis;Biological Assay;C-terminal;Cells;cofactor;Complex;crosslink;Cryoelectron Microscopy;Cystic Fibrosis;Cytosol;design;dimer;Disease;Docking;drug development;egg;Endoplasmic Reticulum;Endoplasmic Reticulum Degradation Pathway;Event;experimental study;Funding;Genetic Diseases;Glycoproteins;Glycoside Hydrolases;Goals;Homo;Human Genetics;Ligase;Lipid Binding;Mammals;Mediating;Medical;Membrane;Membrane Proteins;Metabolism;misfolded protein;Modeling;Monoubiquitination;multicatalytic endopeptidase complex;novel;novel therapeutics;Nuclear Pore;Organelles;Paper;Pathway interactions;Peroxisomal Disorders;peroxisome;peroxisome lumen;Process;Progress Reports;protein degradation;Protein Import;protein oligomer;protein purification;Protein translocation;protein transport;Proteins;Publications;Publishing;receptor;receptor binding;receptor recycling;reconstitution;Recycling;Saccharomyces cerevisiae;Signal Transduction;Structure;System;Testing;Thinness;Toxin;ubiquitin ligase;Ubiquitination;Virus;Work;Xenopus;Zellweger Syndrome

PROJECT_TITLE: Protein Transport Across Membranes

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Project Narrative - OVERALL Microbiomes, critical to human health and functioning, are embedded within and are influenced by environmental context. By gaining a deeper understanding of how microbial variation affects human health, we can devise holistic strategies to promote a sustainable, resilient biosphere.

PI_NAMEs: AMEND, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Address;Affect;Animals;base;biobank;Biochemistry;Biological Sciences;Biology;biomedical resource;Businesses;Career Mobility;Centers of Research Excellence;Chemicals;Clinical;Clinical Research;cohort;Collaborations;Communities;Complement;Complex;Core Facility;Dedications;design;Development;Ecology;Ecosystem;Educational workshop;Eligibility Determination;Ensure;Environment;Environmental Health;Environmental Impact;Environmental Microbiology;experience;Exposure to;Extramural Activities;Faculty;Fostering;Funding;Future;Genetic;Goals;Grant;Hawaii;Hawaiian;Health;Health Sciences;Histologic;Home;Human;Human body;Human Microbiome;Human Resources;Image;improved;Infrastructure;innovation;Insecta;insight;Institution;Interdisciplinary Study;Internet;Invertebrates;Investigation;Island;Knowledge;Leadership;Link;member;Mentors;Mentorship;Microbe;microbial;microbial community;microbiome;microbiome research;Modeling;Molecular;multidisciplinary;Native Hawaiian;novel;Output;outreach;Pathogenicity;Pattern;Persons;Phase;Phylogenetic Analysis;Pilot Projects;Planet Earth;Play;professor;programs;Protocols documentation;Qualifying;Records;recruit;Research;research facility;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;resilience;Resources;response;Role;rural setting;Scientist;Sea;Seasons;Services;socioeconomics;Standardization;success;symbiont;symposium;System;tool;transcriptome sequencing;United States National Institutes of Health;Universities;urban setting;Variant;Work

PROJECT_TITLE: Integrative Center for Environmental Microbiomes and Human Health


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Microbiome

PROJECT_TERMS: Administrative Efficiency;Advisory Committees;Amendment;Appointment;Area;Attention;base;Biological Sciences;Budgets;Centers of Research Excellence;Communication;Communities;community building;Core Facility;data portal;Databases;design;Development;Development Plans;Education and Outreach;Employee;Ensure;Equipment;Equipment and supply inventories;Evaluation;expectation;experience;Faculty;Feedback;Fertilization;Fostering;Future;Goals;Hawaii;Hawaiian;Health;Human;Human Microbiome;Human Resources;improved;Individual;Infrastructure;International;Internet;Island;Joints;Knowledge;Laboratories;Leadership;Link;Maintenance;Manuscripts;meetings;member;Mentors;Mentorship;Methods;microbiome;microbiome research;mid-career faculty;Monitor;Occupational activity of managing finances;operation;organizational structure;Output;Periodicals;Pilot Projects;Positioning Attribute;Preparation;programs;Progress Reports;Records;Research;research and development;Research Personnel;Research Project Grants;resilience;Resources;Scientist;Standardization;symposium;synergism;Training;Training Activity;Travel;United States National Institutes of Health;Universities;Visit;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE: The Emergence of polymyxin resistant Klebsiella pneumoniae (PRKP) threatens a vital treatment approach for carbapenem resistant Enterobacteriaceae (CRE) infections. The proposed research will utilize a novel CRISPR- Cas9 system to characterize the genetic determinants of PR in KP and how these genetic changes induce resistance and alter bacterial fitness and virulence. A definitive understanding of how PR develops is necessary in the diagnosis, treatment and prevention of PRKP infections.

PI_NAMEs: MCCONVILLE, THOMAS HOWE (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Accounting;Affect;Amino Acids;Anabolism;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Bacterial Antibiotic Resistance;bacterial fitness;Bacteriology;beta-Lactams;Biological Assay;Biometry;carbapenem resistance;carbapenem-resistant Enterobacteriaceae;carbapenemase;career;career development;Cell Physiology;cellular targeting;Characteristics;Clinical;clinical practice;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Communicable Diseases;CRISPR/Cas technology;Death Rate;design;Diagnosis;diagnostic strategy;differential expression;Enterobacteriaceae Infections;Environment;fitness;Funding;Gene Targeting;Genes;Genetic Determinism;genetic manipulation;genetic variant;genome sequencing;Genomics;Genotype;Goals;Growth;immune activation;Immune system;improved;In Vitro;Induced Mutation;Infection;inhibitor;K-Series Research Career Programs;Klebsiella pneumoniae;Knock-out;Laboratories;Lipid A;Lipopolysaccharides;Lung Lavage Fluid;Mass Spectrum Analysis;Measures;Mediating;Medical center;Mentors;Microbiology;Minimum Inhibitory Concentration measurement;Missense Mutation;Modeling;Modification;Molecular Biology;Molecular Biology Techniques;mouse model;multidisciplinary;Mus;mutant;Mutation;Nature;Nose;novel;Operon;Pathogenesis;Pathway interactions;Pattern;Pentosephosphate Pathway;Phenotype;Play;pneumonia model;Polymyxin Resistance;Polymyxins;Predisposition;Prevention;Prevention strategy;Public Health;Research;Research Personnel;Resistance;Resistance development;resistant Klebsiella pneumoniae;Role;System;Testing;Thin Layer Chromatography;tool;Training;transcriptome sequencing;Translational Research;treatment strategy;United States National Institutes of Health;Universities;Up-Regulation;Variant;Virulence;whole genome;Work

PROJECT_TITLE: Elucidating the genotypic determinants and phenotypic effects of polymyxin resistance in Klebsiella pneumoniae utilizing CRISPR-Cas9

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Microbiome

PI_NAMEs: CULLEY, ALEXANDER  (contact)

PROJECT_TERMS: Aging;Area;Bacteria;Biological;biological research;Biological Sciences;Biology;Biomedical Research;career;Centers of Research Excellence;Client;Collaborations;Communities;Computers and Advanced Instrumentation;Core Facility;cost;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Analyses;Education;Educational workshop;Electron Microscope;Electron Microscopy;Elements;Environment;Equipment;Extracellular Matrix Proteins;Faculty;fluorescence imaging;Fluorescent Probes;Fostering;Funding;Goals;Growth;Guidelines;Hawaii;Health;Height;Histology;Human;Image;Image Analysis;imaging facilities;Imaging technology;Infrastructure;Institution;instrument;instrumentation;Laboratories;laser tweezer;Lasers;Leadership;light microscopy;Location;materials science;Measures;member;Mentorship;Microbe;Microbiology;microbiome;microbiome research;Microdissection;microorganism;Microscope;microscopic imaging;Microscopy;Modernization;new technology;novel;optic tweezer;Outcome;particle;Phase;Preparation;programs;Protocols documentation;Publications;recruit;Research;Research Personnel;Research Project Grants;Research Support;Research Training;Resolution;Scanning;Scientist;Services;Specimen;Students;Subcellular structure;System;Taxus;Technical Expertise;Techniques;Technology;Tissues;tool;Training;Training Activity;training opportunity;transmission process;United States National Institutes of Health;Universities;Viral;virology;Visit;Visualization;webinar

PROJECT_TITLE: Microscopy Imaging Center for Research through Observation (MICRO) Core


ORG_DEPT: NEUROLOGY

PHR: Laboratory and clinical neuroscience have advanced markedly in recent years, and there is now a growing role for clinician-scientists to translate developments in neuroscience into improvement in clinical care. Training young neurologists at a formative stage of their careers in research methods, and encouraging them to consider research as a career, will increase the number of committed, successful clinician-scientists. This proposal for a renewal of the highly successful Columbia University Neurology Resident Research Education Program will provide talented clinical neuroscience residents with the opportunity to develop research skills that have a high likelihood of reducing the burden of neurological disease.

PI_NAMEs: KUO, SHENG-HAN  (contact)

PROJECT_TERMS: 10 year old;Applications Grants;Award;Basic Science;career;Clinical;clinical care;Clinical Research;Dedications;Development;education research;Educational workshop;Epidemiology;experience;Exposure to;Faculty;faculty mentor;Fellowship;Funding;Future;Goals;Grant;Grant Review;improved;Institution;K-Series Research Career Programs;Laboratories;Laboratory Scientists;Learning;Manuscripts;meetings;member;Mentors;Mentorship;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neuroepidemiology;Neurologist;Neurology;neuropathology;Neurosciences;Neurosurgeon;neurosurgery;Paper;Physicians;Postdoctoral Fellow;posters;Productivity;professor;programs;Publications;Publishing;Records;Research;Research Methodology;Research Personnel;Research Project Grants;Research Technics;Research Training;Residencies;Role;Rotation;Scientist;senior faculty;skills;success;Talents;Taste Perception;Time;Training;Training Programs;Translating;Translational Research;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Neurology Research Education and Mentorship Program


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Microbiome

PI_NAMEs: YEW, JOANNE Y (contact)

PROJECT_TERMS: Acceleration;Aerobic;analytical method;Area;Award;base;biobank;Bioinformatics;Biology;Biomedical Research;career;Centers of Research Excellence;Communities;Data;data analysis pipeline;Destinations;Development;Disease;Doctor of Philosophy;Ecosystem;Education;Educational workshop;Ensure;Environment;Equipment;experience;Faculty;Fostering;Gene Expression;Genomic Library;Genomics;Goals;Grant;Growth;Hawaii;Hawaiian;Health;High Pressure Liquid Chromatography;High-Throughput Nucleotide Sequencing;Human;Infrastructure;instrumentation;interest;Internships;Laboratories;laboratory facility;Laboratory Study;Libraries;Lipids;liquid chromatography mass spectrometry;Mass Spectrum Analysis;Metabolic;metabolomics;Metagenomics;Methods;Microbe;microbial;microbial genomics;Microbiology;microbiome;microbiome research;microbiota;Modernization;Molecular Biology;Native Hawaiian;next generation;normal microbiota;outreach;Phase;Preparation;Privatization;programs;Proteomics;Publications;Qualifying;recruit;Research;Research Methodology;Research Personnel;Research Support;Resolution;Resources;Sampling;Scientist;searchable database;Secure;Services;Shotguns;Site;small molecule;Students;success;Taxus;Technical Expertise;Techniques;Technology;Time;tool;Training;training opportunity;transcriptomics;undergraduate student;Universities;user-friendly;Virus;Visit

PROJECT_TITLE: Microbial Genomics and Analytical Laboratory (MGAL) Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Pain Research;Urologic Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Understanding how underlying disease mechanisms in overactive bladder contribute to the development of urinary symptoms, including urinary urgency and urgency incontinence, is highly relevant to public health. The proposed, interdisciplinary research that includes experts in Urology, Psychology, and chronic pain research will contribute to the fundamental knowledge of how central sensitization relates to bladder sensitivity and to psychological burdens in people with overactive bladder and how this can be measured effectively. This will allow future studies in which interventions to improve bladder health and incontinence can be implemented and outcomes recorded, with the goal of improving bladder health.

PI_NAMEs: MCKERNAN, LINDSEY COLMAN;SEBESTA, ELISABETH M (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: Affect;Anger;Animals;Anxiety;Biological Markers;Bladder;Bladder Control;Caring;central sensitization;Characteristics;Chronic;chronic pain;chronic painful condition;Clinical;CNS processing;comorbidity;Development;diaries;Disease;Ecological momentary assessment;Electronics;Emotions;Esthesia;Etiology;Event;Female;Frequencies;Functional disorder;Future;Goals;Health;Hydration status;Hypersensitivity;improved;Incontinence;indexing;Individual;Individual Differences;innovation;interdisciplinary approach;Interdisciplinary Study;Intervention;Intervention Studies;Knowledge;Link;male;Measures;Mediating;men;Mental Depression;meter;micturition urgency;Modeling;multimodality;negative affect;Nocturia;novel;Oral;Outcome;Overactive Bladder;Pain;Pain Research;Patients;Persons;Pharmaceutical Preparations;Phenotype;phenotypic biomarker;precision medicine;prospective;psychologic;Psychology;Psychophysics;psychosocial;Psychosocial Factor;Public Health;Research;response;Sampling;Sensory;sex;Sex Differences;Signal Transduction;societal costs;Symptoms;Testing;Time;Treatment outcome;urinary;Urinary Incontinence;Urology;Woman;women subjects;Work

PROJECT_TITLE: Central Sensitization and Psychosocial Impacts on Overactive Bladder

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Genome instability can be detrimental to cellular death, but also advantageous to cancer cells – linked to increased tumor progression, metastasis, immune evasion which leads to overall poor patient prognosis. My previous work demonstrated a novel, interphase-independent role of ATR in promoting faithful chromosome segregation, but much remains unknown of how this occurs. The goal of this proposal is to elucidate the molecular mechanisms by which ATR promotes genome stability by defining its non-canonical role in mitosis and interphase.

PI_NAMEs: KABECHE, LILIAN CAROLINA (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: ATR gene;cancer cell;cell growth;Centromere;Cessation of life;Chromosome Segregation;DNA Damage;Drug resistance;Ensure;Genome Stability;Genomic Instability;Goals;Immune Evasion;Interphase;Knowledge;Lamin Type A;Link;Malignant Neoplasms;Mitosis;Mitotic;Molecular;Neoplasm Metastasis;novel;Nuclear;Nuclear Envelope;Pathway interactions;patient prognosis;Phosphorylation;Phosphotransferases;programs;Progranulocytes;Proteins;Regulation;Research;response;Role;tumor progression;Work

PROJECT_TITLE: Elucidating how ATR promotes genome stability independent of the DNA damage response pathway

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: WASHINGTON

ORG_NAME: CARNEGIE INSTITUTION OF WASHINGTON, D.C.

ORG_STATE: DC

PHR: Project Narrative Gut bacteria impact aging in ways that can shorten or extend lifespan depending on which bacteria inhabit the gut. The goal of this proposal is to determine mechanisms by which the host gut creates specialized microenvironments that support specific populations of resident bacteria. Our proposal seeks to overcome key limitations of current research, which are the genetic tractability of host and microbes and a well-defined gut niche. The work may reveal mechanisms that can be applied to engineering a healthy human microbiome.

PI_NAMEs: LUDINGTON, WILLIAM BASIL (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acetobacter;Address;Adhesions;Affect;Aging;assay development;Bacteria;Bacterial Adhesion;Binding;Biological Assay;Biology;Candidate Disease Gene;candidate identification;cell type;Cells;Chemicals;commensal bacteria;Communities;Complementary DNA;cost;Drosophila genus;Drosophila melanogaster;Duct (organ) structure;Engineering;Enhancers;Environment;Enzymes;experimental study;extend lifespan;Extracellular Matrix;fly;Gene Expression;Gene Modified;Genes;Genetic;genetic resource;glycosylation;glycosyltransferase;Goals;Growth;gut bacteria;gut colonization;Health;Health Benefit;Homologous Gene;Human;human disease;Human Microbiome;Ingestion;Island;Kinetics;Knock-out;Knowledge;Lactobacillus;Lactobacillus plantarum;life span;Link;Location;Maintenance;Mediating;Microbe;microbiome composition;microbiota;Molecular;Mucins;Mucous body substance;mutant;Physiology;Polysaccharides;Population;Positioning Attribute;Primitive foregut structure;Probiotics;programs;Proliferating;Proteins;recruit;Regulation;Reproduction;Research;Rest;RNA Interference;Role;Serine;single-cell RNA sequencing;Site;Specificity;stomach cardia;symbiont;Testing;Time;Tissues;tool;transcriptome sequencing;Transferase;translational potential;uptake;Work

PROJECT_TITLE: Host mechanisms of gut colonization by commensal bacteria that affect lifespan

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Vector-Borne Diseases

PI_NAMEs: COUVILLON, PATRICIA A (contact)

PROJECT_TERMS: Address;Advocate;Affect;Agriculture;Arthropods;Award;base;Biodiversity;Biological;Biological Models;Biological Sciences;Biomedical Research;Blood;Breeding;Cell Physiology;Centers of Research Excellence;Chikungunya virus;Collaborations;Collection;Communities;Containment;Core Facility;Culicidae;Dangerousness;Dengue Virus;Development;Disease Outbreaks;Disease Vectors;Drosophila genus;Drosophila melanogaster;Equipment;Fee-for-Service Plans;field study;fly;Food production;Food Webs;Funding;Gene Modified;Generations;Goals;Grant;Hawaii;Hawaiian;Health;Health system;Home;Human;Human Microbiome;human pathogen;immune function;Immunity;Income;Infrastructure;Insect Vectors;Insecta;Institution;Institutionalization;interest;Invertebrates;Laboratories;Link;Maintenance;Malaria;Mediating;Medical;Medical Entomology;medical schools;Metabolism;Microbe;microbial;microbiome;microbiome composition;microbiome research;microbiota;Modeling;Mosquito-borne infectious disease;Native Hawaiian;non-Native;pathogen;Pathway interactions;Phase;Procedures;programs;Protocols documentation;Public Health;Recording of previous events;Research;Research Activity;Research Personnel;Research Support;Resources;Retirement;Role;Secure;Services;Structure;Study models;sucking;symbiont;System;Taxus;Training;Universities;vector mosquito;Vertebrates;West Nile virus;Work;Zika Virus

PROJECT_TITLE: Insectary for Scientific Training and Advances in Research (InSTAR) Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Clinical Research;Disability Research;Pediatric;Physical Rehabilitation;Rehabilitation

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE People seek out upper limb rehabilitation services to improve performance of activities in daily life, with performance defined by the World Health Organization ICF model as what someone actually does in the unstructured, free-living environment. Wearable, motion sensors now allow for direct measurement of upper limb performance in daily life, but performance is rarely measured or considered in research and clinical care. The goal of this project is to identify and validate categories of upper limb performance from wearable sensor data that can be used across populations to facilitate rehabilitation research and clinical care measurement of outcomes that are most relevant to patients.

PI_NAMEs: LANG, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Activities of Daily Living;Address;Adhesive Capsulitis;Adult;Age;Algorithmic Software;arm;Awareness;Biological;Caring;Categories;Child;Childhood;Clinic;Clinical;clinical care;clinical decision-making;Cluster Analysis;cohort;Complex;Computer software;Consumption;dashboard;Data;Development;Dimensions;disability;Disease;Environment;Future;Goals;Human;impaired capacity;Impairment;improved;Individual;Industry;Infant;Intervention Studies;Laboratories;Life;life span;Limb structure;Malignant Breast Neoplasm;Maps;Mathematics;Measurement;Measures;Modeling;motion sensor;Multiple Sclerosis;Neurologic;Outcome;Outcome Measure;Participant;Patient Outcomes Assessments;patient population;Patients;Pediatric cohort;Performance;personalized decision;Persons;Population;post stroke;rehabilitation research;rehabilitation service;rehabilitative care;Reporting;Research;Research Personnel;research study;Self Care;sensor;Stroke;Structure;Time;Toddler;Translations;Upper Extremity;Upper Extremity Fracture;Validation;wearable data;wearable device;wearable sensor technology;Work;World Health Organization

PROJECT_TITLE: Translation of In-Clinic Gains to Gains in Daily Life

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Data Science;Emerging Infectious Diseases;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Public Health Relevance Statement NIH has identified “workforce development” as one of its 5 strategic goals for biomedical data science in the coming decades and has called for integrative training in data-science approaches through curricula and mentored research. This proposed R25 program is designed to address the nationwide shortage of Big Data health science researchers in NIAID focus areas. The training program will target junior faculty in health science disciplines at the University of South Carolina and will foster a research environment to encourage individuals from diverse backgrounds, including those from underrepresented groups, to pursue further Big Data health science research in HIV, COVID-19, and other infectious diseases.

PI_NAMEs: LI, XIAOMING  (contact);ZHANG, JIAJIA

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Academic Training;Address;Applications Grants;Area;Artificial Intelligence;Big Data;Big Data to Knowledge;big-data science;biomedical data science;Biometry;Businesses;career;Cessation of life;Clinical;Clinical Medicine;cohort;college;Communicable Diseases;Communities;community engagement;comorbidity;Competence;COVID-19;Data;data acquisition;Data Science;Data Scientist;Data Sources;data streams;design;Development;digital;Discipline;Discipline of Nursing;Disease;Disease Progression;Education Projects;Educational Curriculum;Electronic Health Record;Entrepreneurship;Environment;experience;Face;Faculty;financial incentive;Fostering;Funding;Funding Agency;Generations;genomic data;Genomics;Goals;hands on research;Health;Health Care Research;health data;Health Policy;health science research;Health Sciences;health training;Healthcare;high risk population;HIV;HIV/AIDS;improved;Individual;Industry;Infectious Diseases Research;Information Technology;Infrastructure;innovation;interest;Knowledge;Machine Learning;Manuscripts;Measures;Medicine;Mentors;Methodology;Mission;mobile computing;National Institute of Allergy and Infectious Disease;Outcome;peer;peer coaching;Pharmacy facility;prevent;professor;programs;Public Health;public health intervention;public health relevance;recruit;Research;Research Personnel;Research Project Grants;Research Proposals;Schools;Science;skill acquisition;skills;social media;Social Work;South Carolina;Strategic Planning;synergism;System;Talents;Technology;Time;Training;training data;Training Programs;trend;Underrepresented Populations;United States National Institutes of Health;Universities;Virus;Wages;wearable device;Workforce Development

PROJECT_TITLE: Big Data Health Science Fellow Program in Infectious Disease Research


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: Project narrative Improvements in the surgical and medical care of children with congenital heart disease (CHD) have increased survival. Among survivors, however, there is a high prevalence and significant long-term impact of cognitive and behavioral problems and medical complications including heart failure and problems with growth. The goal of this study is to determine the genetic contributions to clinical outcomes in individuals with CHD and to begin to use this information in clinical care.

PI_NAMEs: CHUNG, WENDY K;GELB, BRUCE D;SHEN, YUFENG  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, BRYANNA NICOLE

PROJECT_TERMS: Affect;Age;Anatomy;Aneuploidy;Applied Genetics;Arrhythmia;base;biobank;blind;Brain;Candidate Disease Gene;candidate identification;Cardiac;Cardiac Death;Cardiovascular system;Caring;case finding;Child Care;Classification;Clinical;clinical care;Clinical Treatment;Clinical Trials;Clinical Trials Design;Cognitive;cohort;Collaborations;congenital heart abnormality;Data;Databases;design;Development;Diagnostic;digital;Disease Outcome;Down's Syndrome;Education;Enrollment;Etiology;Exclusion;Exercise;exome sequencing;Family;Funding;Genes;Genetic;Genetic Diseases;genetic variant;Genetic Variation;genome sequencing;genomic data;Genomic DNA;Genotype;Goals;Growth;heart disorder diagnosis;Heart failure;Height;High Prevalence;improved;improved outcome;indexing;Individual;individual patient;Inherited;insight;instrument;Intervention;Laboratories;Medical;medical complication;Medical Records;model building;Molecular Genetics;Morbidity - disease rate;mortality;Motion;neurodevelopment;Neurodevelopmental Disorder;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Other Genetics;Outcome;outcome prediction;Pathogenicity;Patients;Pediatric Cardiac Genomics Consortium;Phenotype;pleiotropism;polygenic risk score;population based;premature;prevent;proband;Problem behavior;programs;prospective;randomized, clinical trials;Reporting;Research;Risk;Risk Estimate;Role;Site;Socioeconomic Status;Standardization;Statistical Methods;Survivors;Syndrome;System;Testing;Therapeutic;Training;Translating;transmission process;Transplantation;treatment trial;Update;Variant;Ventricular Function

PROJECT_TITLE: Identifying and applying genetic variation relevant to clinical outcomes for individuals with congenital heart disease


ORG_CITY: LOS ANGELES

ORG_NAME: CALIFORNIA STATE UNIVERSITY LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative The Bridge to the Doctorate at Cal State LA Program will increase the numbers of traditionally under- represented doctoral-level scientists engaged in biomedical research to enhance the health of the US public. These individuals will be more likely to work on health disparities specific to minority populations.

PI_NAMEs: MOTA-BRAVO, LUIS M;PAYNE, GREGORY S;VELLANOWETH, ROBERT L (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: bridge to the doctorate;programs

PROJECT_TITLE: Bridges to the Doctorate Program at Cal State LA

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Microbiome;Neurosciences;Nutrition;Obesity

PI_NAMEs: HAGLUND, ELLINOR  (contact)

PROJECT_TERMS: Affect;Animals;Automobile Driving;Behavior;Binding;Biological;Biological Models;Biology;biophysical properties;Cellular Assay;Characteristics;Chronic;comparison control;Complex;Cryoelectron Microscopy;Cytokine Receptors;Diabetes Mellitus;Diet;diet-induced obesity;Drosophila genus;Drosophila melanogaster;Electron Microscopy;Electron Transport;Environment;Enzymes;experimental study;fly;Genetic Models;Germ-Free;Glean;glycosylation;Goals;gut microbiome;gut microbiota;gut-brain axis;Health;Homeostasis;Hormones;host microbiota;Human;human disease;In Vitro;in vivo;insight;interdisciplinary approach;Interdisciplinary Study;knock-down;Leptin;leptin receptor;Link;microbial composition;microbiome;microbiome composition;microbiota;microbiota composition;Molecular;Molecular Conformation;molecular dynamics;Nutritional status;Obesity;obesogenic;Phenotype;Play;Positioning Attribute;Post-Translational Protein Processing;Property;protein structure;Proteins;receptor;receptor function;Regulation;Research;response;Role;self assembly;Signal Transduction;Site;stoichiometry;Stress;Structure;targeted treatment;Testing;Transgenic Organisms;Transmission Electron Microscopy;Vertebral column

PROJECT_TITLE: A Small Contribution to a Large Problem: Leptin-Signaling and the Gut-Brain Axis


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Social determinates of health (SDoH) play a significant role in why 1.7 million Americans suffer from opioid use disorders (OUD) and 47,000 American die from opioid overdose. This study will use natural language processing and machine learning to identify SDoH in clinical notes, examine associations between SDoH and OUD, and develop a clinical decision support (CDS) tool to automatically assess OUD risk. Such a CDS tool will help clinicians quickly and accurately assess OUD risk, intervene earlier, and improve care and patient outcomes.

PI_NAMEs: BROWN, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: addiction;Address;Affect;American;Assessment tool;biomedical informatics;care outcomes;career;career development;Caring;Clinical;clinical decision support;Code;Computerized Medical Record;County;Data;Data Scientist;Diabetes Mellitus;Diagnosis;disorder risk;Documentation;Drug Prescriptions;Education;Evaluation;experience;food insecurity;Foundations;Goals;Health;Health Insurance Portability and Accountability Act;heuristics;HIV;Hospitals;housing instability;ICD-10-CM;improved;Information Systems;innovation;Institution;Institutional Review Boards;International;Intervention;Interview;Knowledge;knowledgebase;Logical Observation Identifiers Names and Codes;Machine Learning;machine learning algorithm;Manuals;Maps;Measurement;Measures;Medical;medication-assisted treatment;Mentors;Mentorship;Metadata;Modeling;Natural Language Processing;novel;opioid epidemic;opioid mortality;opioid overdose;opioid use;opioid use disorder;Outcome;Output;Participant;patient oriented;Patient-Focused Outcomes;Patients;Performance;Physicians;Play;prescription opioid;Procedures;Questionnaires;Recommendation;recruit;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk;Risk Assessment;Risk Factors;Role;Running;safety net;Sampling;skills;SNOMED Clinical Terms;social;social health determinants;Specialist;statistics;success;supervised learning;support tools;Surveys;System;Technology;Terminology;Testing;Text;therapy design;therapy development;Time;tool;Training;trial readiness;usability;Vocabulary;Work

PROJECT_TITLE: Developing a Clinical Decision Support Tool that Assesses Risk of Opioid Use Disorder Using Natural Language Processing, Machine Learning, and Social Determinants of Health from Clinical Notes

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases;Microbiome

PI_NAMEs: JANI, ANDREA  (contact)

PROJECT_TERMS: Acceleration;Activities of Daily Living;Affect;Antibiotics;Biological;Climate;climate change;Communicable Diseases;Communities;Containment;Development;dietary;Disease;Disease Outbreaks;DNA sequencing;Drosophila genus;Drosophila melanogaster;Ecology;environmental stressor;experience;Exposure to;fly;Foundations;Future;Genes;Germ-Free;Global Change;Goals;Hawaii;Hawaiian;Health;Human;human disease;Human Microbiome;Immune response;improved;Infection;Insecta;Knowledge;Laboratories;Lead;Link;Measures;Mentors;Metagenomics;Microbe;microbial;microbial community;microbial composition;microbiome;microbiome alteration;microbiome analysis;microbiome composition;microbiota transplantation;model organism;Modeling;Molecular;Natural experiment;Organism;Outcome;pathogen;pathogen exposure;pathogenic bacteria;pathogenic microbe;Phylogenetic Analysis;Population;Predictive Factor;Qualifying;Recurrent disease;Research;Research Project Grants;resilience;Resistance;response;Shotguns;Stress;stress tolerance;Structure;success;symbiont;System;Taxus;Temperature;Testing;thermal stress;transcriptomics;Variant;Work

PROJECT_TITLE: Determinants of Microbiome Stability Following Pathogen Infection


NIH_SPENDING_CATS: Clinical Research;Pediatric

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Narrative The expansion of the successful SciTrek program to more than twice as many local 2nd‐8th grade classroom will provide more data to demonstrate the effectiveness of the program. Furthermore, this will allow the program to address a fundamental question regarding if the program can influence elementary students’ attitudes towards science, which is suggested to cause girls and under represented minorities to leave the STEM field. Expansion of the program to other institutions and distant schools lacking the appropriate resources has broad significance.

PI_NAMEs: REICH, NORBERT O. (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Affect;Attitude;Belief;California;career;Channel Islands;Cities;cohort;college;Critical Thinking;Data;Data Analyses;Development;Distant;Education;effectiveness evaluation;eighth grade;elementary school;Engineering;evidence base;Female;Fostering;Geography;girls;Goals;high school program;Human Resources;improved;Institution;interest;K-12 student;Knowledge;Lead;mathematical ability;Mentors;Methods;Minority;Modeling;organizational structure;Outcome;outreach program;Ownership;pedagogy;Performance;Philosophy;Population;posters;Program Effectiveness;programs;recruit;Research;Resources;Running;Schools;Science;Science, Technology, Engineering and Mathematics Education;Scientist;Shapes;Sister;Site;skills;STEM career;STEM field;Students;teacher;Teacher Professional Development;Thinking;Training;Underrepresented Minority;Universities;volunteer;Work;Writing

PROJECT_TITLE: SciTrek: How Science Works

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative We will develop a new class of molecular probes to visualize and control the dynamic signals that regulate all cell and tissue function. Because our tools are modular, our designs will be widely applicable to study diverse physiological processes, as well as their breakdown in disease. Importantly, our probes could in the future be adapted as sensors of several disease states including neurodegeneration and certain cancers, and thus will present powerful opportunities to study and ultimately treat a broad range of human disease.

PI_NAMEs: BUGAJ, LUKASZ  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: aggregation pathway;Behavior;Biochemical Process;Biosensor;Cancer Model;Cell Culture Techniques;Cells;design;Development;Disease;Engineering;experimental study;Future;Genetic Transcription;Genomics;Goals;human disease;In Vitro;interest;Intestines;Malignant Neoplasms;Microscopy;Mission;Modeling;Modification;Molecular Probes;National Institute of General Medical Sciences;Nerve Degeneration;novel;optogenetics;Organoids;overexpression;Pathway interactions;Pattern;Phase;Physiological;Physiological Processes;Physiology;protein aggregation;Proteins;receptor;Reporter;Reporting;response;sensor;Signal Pathway;Signal Transduction;Signaling Protein;simulation;spatiotemporal;success;Time;Tissues;tool;Visible Radiation;Visual;Visualization;WNT Signaling Pathway;Work

PROJECT_TITLE: Dynamic probes of endogenous protein aggregation and cell signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: MILLER, CORRIE  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;37 weeks gestation;Affect;Anti-Inflammatory Agents;Anxiety;Area;beta diversity;Biological Markers;Birth;Birth Rate;Black Populations;Black race;black women;Childhood;Clinical;Communities;cytokine;Dedications;Diet;Dietary intake;Discrimination;dysbiosis;early pregnancy;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;ethnic disparity;Ethnic Origin;Etiology;experience;Filipino;food insecurity;Gardnerella;Goals;Hawaii;Health;health care availability;Health Care Costs;Health Disparities Research;high risk;High Risk Woman;Human;Income;Infant Mortality;Inflammatory;inflammatory marker;Institutional Racism;interest;Lactobacillus;Libraries;Link;Machine Learning;Mass Spectrum Analysis;Measures;Mentorship;Methods;microbial;microbial community;microbial composition;microbiome;microbiome composition;Modeling;Molecular;Morbidity - disease rate;multi-ethnic;Native Hawaiian;Native Hawaiian or Other Pacific Islander;neonatal morbidity;neonate;Not Hispanic or Latino;nutrition;offspring;parous;Participant;Pathway interactions;Pattern;point of care testing;Pregnancy;Pregnant Women;premature;Premature Birth;Premature Labor;Premature Rupture Fetal Membranes;prevent;Prevention;Probiotics;Proteins;Protocols documentation;Race;racial disparity;racism;recruit;Reproductive Health;Research;resilience;Resources;Risk;risk mitigation;Role;Sampling;Signal Transduction;social adversity;social determinants;social disparities;social health determinants;Social Interaction;social stress;Socioeconomic Status;Stress;success;Surveys;Swab;targeted treatment;Techniques;theories;Unhealthy Diet;Vagina;vaginal microbiome;vaginal microbiota;Variant;White Women;Woman

PROJECT_TITLE: Social Determinants and Vaginal Microbiome Effects on Preterm Birth in Hawaii


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Health Services;Human Genome;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Increasing numbers of patients are seeking genetic counseling and testing to inform medical care and there is an urgent need to test ways to optimize the genetic counseling process to meet this growing demand. We will conduct a 3-arm randomized clinical trial to test two complementary approaches to shifting the primary genetic counseling session to post-test results-focused counseling for adults attending cardiovascular genetic counseling for diagnostic next-generation sequencing panel testing or family-specific variant testing. We hypothesize that post-test genetic counseling will: 1) increase efficiency, 2) promote patient empowerment and adherence, and 3) have similar psychosocial impact.

PI_NAMEs: JAMES, CYNTHIA A (contact)

PROGRAM_OFFICER_NAME: KULCHAK RAHM, ALANNA LEE

PROJECT_TERMS: Adherence;Adult;Affect;Anxiety;Appointment;arm;arrhythmogenic cardiomyopathy;behavior change;behavioral response;Bioinformatics;Calculi;Cardiac;Cardiovascular system;Caring;Client satisfaction;Clinical Trials;Communication;Counseling;Data;Decision Making;design;Dose;Education;empowerment;evidence base;exome;experience;Family;fetal loss;General Population;Genetic;Genetic Counseling;genetic counselor;genetic information;genetic testing;Genome;genome sequencing;Genomic medicine;Genomics;Growth;Health;Huntington Disease;improved;Insurance;Intervention;Measures;Medical;medical specialties;Methodology;Modeling;multidisciplinary;next generation sequencing;novel diagnostics;Observational Study;Outcome;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Pilot Projects;prenatal;Prevalence;Procedures;Process;psychosocial;randomized, clinical trials;Recommendation;Research;Resource-limited setting;Risk;Role;Scientist;Severities;standard of care;Statistical Data Interpretation;Technology;Telephone;Test Result;Testing;Time;treatment arm;treatment as usual;Uncertainty;Variant

PROJECT_TITLE: Randomized clinical trial of the sequence of genetic counseling and testing to optimize efficiency, patient empowerment and engagement, and medical adherence for diverse genetic testing indications


NIH_SPENDING_CATS: Natural Products

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative  Incorporation of isotopically labeled carbon-14 atoms into bioactive compounds is required during all stages of preclinical and clinical drug development. Processes that allow carbon isotope exchange directly on drug candidates are of great importance to chemistry, biology, and medicine. Especially valuable are catalytic procedures that rely on a limited collection of available labeled materials.

PI_NAMEs: BUKHRYAKOV, KONSTANTIN  (contact)

PROJECT_TERMS: Alkenes;Area;Biology;C14 isotope;Carbon;Carbon Isotopes;catalyst;Chemistry;Clinical Drug Development;Collection;Complex;dehydrogenation;design;Development;drug candidate;Drug Kinetics;Ethylenes;functional group;innovation;isotope incorporation;Isotope Labeling;Isotopes;Label;Mediating;Medicine;Metabolic;Methods;methyl group;methyl iodide;Natural Products;Pharmaceutical Preparations;Pharmacologic Substance;Positron-Emission Tomography;pre-clinical;Procedures;Process;Protocols documentation;Source;tool;Transition Elements;Vanadium;Work

PROJECT_TITLE: Carbon isotope exchange mediated by vanadium complexes


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Neurosciences;Women's Health Research

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE This research project will study the effects of sympathetic stimulation on cardiac ionic currents responsible for ventricular fibrillation, a lethal heart rhythm disorder. Because heart rhythm disorder is a major cause of sudden death, this study is clinically significant.

PI_NAMEs: CHEN, PENG-SHENG  (contact);QU, ZHILIN

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Acetylcholine;Action Potentials;Adrenergic Agents;Adrenergic Receptor;Agonist;antagonist;Anti-Arrhythmia Agents;Apamin;Arrhythmia;Arteries;Atrioventricular Block;Autonomic nervous system;beta-2 Adrenergic Receptors;Brain;Buffers;canine model;Cardiac;Catecholamines;Cells;Charybdotoxin;Chemicals;clinically significant;Computer Simulation;Coronary;Disease;Electric Countershock;Embryo;Endothelium;experimental study;FDA approved;Female;Funding;Goals;Heart;Heart Atrium;heart rhythm;Human;indium arsenide;Infusion procedures;Isoproterenol;kidney cell;Left;male;Maps;Mediating;Messenger RNA;Modeling;Myocardial Infarction;Myocardium;Na(+)-K(+)-Exchanging ATPase;Nerve;Nerve Growth Factors;Neurons;Nitric Oxide Synthase;Optics;Oryctolagus cuniculus;Ouabain;Overactive Bladder;patch clamp;Patients;Pharmaceutical Preparations;Phase;Play;Proteins;Recurrence;Relaxation;Reporting;Research Project Grants;Resistance;response;Role;Sex Differences;Shock;Structure of stellate ganglion;sudden cardiac death;Sudden Death;Syndrome;Testing;Translations;Vasodilation;Ventricular;Ventricular Arrhythmia;Ventricular Fibrillation;Ventricular Tachycardia

PROJECT_TITLE: SK Current, beta-3 adrenoceptor activation and Sex Differences in Ventricular Arrhythmogenesis

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: ITHACA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Correlations among mutations naturally arise and decay along the branches in an ancestral recombination graph (ARG) due to mutation, coalescence, and recombination. Developing novel statistical genetics methods on whole-genome ARGs will lead to faster, better-powered, and more rigorous approaches for studying and understanding the genetics and evolution of complex traits. The proposed methods can be directly applied to study human diseases and enable new discoveries.

PI_NAMEs: WEI, XINZHU  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Algorithms;biobank;Calibration;causal variant;Code;Complex;Computer software;computerized tools;Computing Methodologies;Data;Data Set;Evolution;Gene Structure;Genealogy;Genetic;Genetic Diseases;genetic pedigree;Genetic Polymorphism;Genetic Recombination;genome sequencing;genome wide association study;Genotype;Graph;Heritability;human disease;Human Genome;improved;Individual;Linkage Disequilibrium;Maps;Measurement;Methodology;Methods;Modeling;Mutation;novel;Paper;Phenotype;Population;Population Genetics;reconstruction;response;Running;scalable algorithms;Structure;Testing;Time;trait;Uncertainty;whole genome

PROJECT_TITLE: Dissecting the genetics and evolution of complex traits using whole-genome genealogies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE To proliferate successfully, cells must divide and maintain genome integrity, and aberrations in these processes underlie important human diseases such as cancer. Our studies will define how key enzymes and organelles regulate and perform cytokinetic abscission, the final irreversible step in cell division. This information will provide mechanistic understanding of a fundamental step in cell division, and help to reveal how cells prevent genome instability and cancer.

PI_NAMEs: HILL, CHRISTOPHER P.;SUNDQUIST, WESLEY I. (contact);ULLMAN, KATHARINE S

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TITLE: ESCRT and MIT Complexes in Cytokinesis


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PHR: Project Narrative The goal of this proposal is to investigate the significance and mechanisms of the inflammatory cell death pyroptosis and necroptosis as well as their interactions with the cytokine macrophage migration inhibitory factor (MIF) in human monocytes activated by lupus autoantigens and antibodies. The results of the proposal will advance our understanding in the pathogenesis of lupus and provide scientific justifications for targeting pyroptosis, necroptosis, and MIF in lupus.

PI_NAMEs: KANG, INSOO  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: adaptive immunity;Address;Affect;anti-dsDNA antibodies;Antibodies;Antigen-Antibody Complex;Autoantibodies;Autoantigens;Biological Assay;CASP1 gene;Caspase;Cell Death;Cell Death Induction;Cells;Characteristics;chemokine;Clinical;cytokine;Data;Dendritic Cells;Disease;ds-DNA;Exposure to;Frequencies;Goals;high dimensionality;Human;IL18 gene;Immune response;improved;Inflammasome;Inflammation;Inflammatory;inhibitor;Interferon alpha;Interleukin-1 beta;Ku70 protein;Link;Lupus;lupus prone mice;Mediating;Membrane;Migration Inhibitory Factor;mixed lineage kinase 3;Molecular;monocyte;Mus;Natural Immunity;novel strategies;Nuclear;Organ;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Pattern;Phosphotransferases;Production;Protein Kinase Interaction;Publishing;Receptor-Interacting Protein;Reporting;response;RIPK1 gene;RIPK3 gene;Role;Serology;single cell analysis;single-cell RNA sequencing;Small Nuclear Ribonucleoproteins;synergism;Systemic Lupus Erythematosus;Testing;Text;tissue injury;TNF gene;Treatment Efficacy;U1 Small Nuclear Ribonucleoprotein

PROJECT_TITLE: Investigating monocyte activation pathways in lupus

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Cancer;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_DEPT: GENETICS

PHR: Narrative The human papillomaviruses (HPV) are responsible for approximately 5% of all cancers worldwide and most people, including minority populations in the U.S., will remain unvaccinated against HPV for the foreseeable future. We have identified and characterized cellular proteins required for HPV infection, and here we will focus on the role of these proteins in trafficking of HPV to the nucleus during infection. These studies will provide proof-of-principle of new approaches to inhibit infection by these important human tumor viruses and the cancers they cause and provide new insights into fundamental cellular processes.

PI_NAMEs: DIMAIO, DANIEL C. (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Adopted;Amaze;Anogenital venereal warts;anti-cancer research;Binding;Binding Sites;Biology;Cancer Etiology;Capsid Proteins;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Cytoplasm;design;experimental study;Funding;Future;Genetic;genetic analysis;genetic approach;Grant;HIV;HPV analysis;Human;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Infection;innovation;insight;Integral Membrane Protein;Journals;L2 viral capsid protein;Malignant Neoplasms;Maps;Membrane;Minority Groups;mutant;National Cancer Institute;novel;novel strategies;Oncogenic Viruses;Papilloma;Papillomavirus;pathogen;Pathway interactions;Penetration;Peptides;Persons;Phenotype;prevent;protein aminoacid sequence;Proteins;Public Health;Publishing;receptor;retrograde transport;Role;Seminal;Sorting;System;Testing;Time;trafficking;tumor;unvaccinated;Vaccination;vaccine acceptance;Vaccines;Virion;virology;virome;Virus;Virus Diseases

PROJECT_TITLE: Mechanisms of human papillomavirus entry


NIH_SPENDING_CATS: Digestive Diseases;Hematology;Liver Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: Project Narrative The experiments in this proposal are aimed at elucidating the role of stellate cells as a key niche component of the liver HSC niche. The information gained through this project will advance our understanding of the extrinsic mechanisms that regulate HSCs. This may help improve methods of ex vivo expansion of HSCs for clinical use and devise ways to regenerate HSC niche in vivo. !

PI_NAMEs: DING, LEI  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Adult;Aging;Biological Assay;Birth;Blood;Blood Cells;Blood Vessels;Bone Marrow;candidate identification;Cell Maintenance;cell type;Cells;Cellular biology;Cleavage Under Targets and Release Using Nuclease;Clinic;Clinical;cytokine;Data;Defect;Development;Endothelial Cells;Environment;experimental study;Extramedullary Hematopoiesis;fetal;Fetal Development;Fetal Liver;Foundations;Generations;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Cell Growth Factors;hematopoietic stem cell expansion;hematopoietic stem cell niche;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hepatocyte;improved;in vivo;insight;Knock-in Mouse;Knowledge;Life;Liver;Malignant Neoplasms;Mediating;Methods;Molecular Biology;Mus;Natural regeneration;Nature;novel;Organ;Play;Research;Role;self-renewal;single-cell RNA sequencing;Source;stellate cell;stem cell exhaustion;Stem Cell Factor;stem cell function;stem cell migration;Stress;Supporting Cell;System;Testing;Tissues;transcription factor;Vascular blood supply

PROJECT_TITLE: Understanding the role of stellate cells in the liver hematopoietic stem cell niche

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative Chickens and other avian species provide a good model for the study of human diseases; however, their use has been greatly limited due to the lack of tools to genetically modify them. We have for the first time established authentic embryonic stem cells from chickens and other avian species. We will use these embryonic stem cells to develop a genetic toolkit for the generation of transgenic avian species for the study of human diseases and for conservation of endangered avian species.

PI_NAMEs: YING, QILONG  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Anser species;Back;Biological Assay;Birds;Breeding;Cell Line;Cell Lineage;Cells;Chick Embryo;Chicken Cells;chicken egg;Chickens;Chimera organism;Chimerism;Communities;Derivation procedure;Developmental Biology;differentiation in vitro;Ducks;early embryonic stage;Embryo;embryonic stem cell;ES Cell Line;Excision;Fibroblasts;Geese;Gene Expression Profiling;Gene Modified;Gene Targeting;Generations;Genes;Genetic;Genetic Engineering;Germ Cells;Germ Layers;Germ Lines;human disease;induced pluripotent stem cell;induced pluripotent stem cell technology;inhibitor;knockout gene;LIF gene;Meleagris gallopavo;Methods;Modeling;Mus;offspring;pluripotency;Production;Protein Kinase C Inhibitor;Quail;Rattus;Reporter;Research;Signal Pathway;small molecule;small molecule inhibitor;Specific qualifier value;stem cell differentiation;Structure of primordial sex cell;Struthio camelus;Study models;Technology;Testing;Time;tool;transcription factor;Transforming Growth Factor beta;Transgenic Organisms;transmission process;WNT Signaling Pathway;zebra finch

PROJECT_TITLE: Chicken embryonic stem cells