NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

PI_NAMEs: BRUCHAS, MICHAEL R. (contact)

PROJECT_TERMS: addiction;Anhedonia;Animal Model;Animals;awake;Basic Science;Behavior;Behavior assessment;Behavioral;Biosensor;Brain;Brain region;Calcium;cell type;Cells;Center Core Grants;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Communities;computational neuroscience;computer program;Coupled;Data;data analysis pipeline;Data Set;Deep Brain Stimulation;density;Discipline;Disease;Dissection;Educational workshop;Electrophysiology (science);empowerment;Exposure to;Extramural Activities;Feasibility Studies;Fiber;fluorescence imaging;Fluorescent in Situ Hybridization;Fostering;Foundations;Functional disorder;Functional Imaging;Funding;Gene Expression;Gene Expression Profiling;Gene Targeting;Genes;Genetic;genetic resource;Goals;Head;High School Student;Historically Black Colleges and Universities;holographic stimulation;Holography;Image;imaging facilities;Imaging technology;in vivo;in vivo fluorescence;Individual;Infrastructure;instrumentation;interest;Investigation;Label;Laboratories;lens;Light;Manuscripts;Mediating;Microscope;Microscopy;Modeling;Modernization;Molecular;Molecular Genetics;motivated behavior;Motivation;multidisciplinary;multiple datasets;Mus;National Institute of Drug Abuse;neural;neural circuit;Neurobiology;Neurons;Neurosciences;new technology;novel;novel virus;open source;open source tool;Opiate Addiction;Opioid;opioid abuse;Optics;optogenetics;outreach;Overdose;Participant;Pharmaceutical Preparations;Photometry;Postdoctoral Fellow;Preparation;programs;Protocols documentation;Relapse;Research;Research Personnel;Resolution;Resources;Rewards;RNA;Role;Scientist;Self Administration;Stress;Structure;Students;Substance abuse problem;synthetic opioid;System;Techniques;Technology;Thick;Time;Tissues;tool;Training;training opportunity;transcriptomics;two photon microscopy;two-photon;undergraduate student;Universities;Viral;Washington;Work

PROJECT_TITLE: Imaging and Neural Circuits Core


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: ZWEIFEL, LARRY S (contact)

PROJECT_TERMS: addiction;Address;Behavioral;Biological Models;Brain region;career;Cell Physiology;cell type;Central Nervous System;Communities;Consultations;CRISPR/Cas technology;delivery vehicle;design;Detection;Development;disadvantaged background;disadvantaged student;Disease;Dissection;drug of abuse;Education;Educational workshop;endogenous opioids;Ensure;Evolution;experimental study;Fiber;Functional disorder;Gene Expression;Gene Targeting;Generations;Genes;Genetic;genetic approach;genetic resource;Genetic Techniques;Goals;graduate student;Health;high resolution imaging;Image;Imaging technology;improved;in vivo;in vivo evaluation;in vivo imaging;innovation;Institution;Investigation;Light;Mediating;Mentors;Methodology;Methods;Microscopy;Molecular;Molecular Genetics;Monitor;Monkeys;Mus;National Institute of Drug Abuse;neural circuit;Neuropeptides;Neurotransmitters;new technology;next generation;novel;Opiate Addiction;Opioid;Opioid Receptor;optogenetics;Pathway Analysis;Photometry;Photons;Post-Translational Protein Processing;Postdoctoral Fellow;Process;protein transport;Proteomics;Qualifying;Rattus;Reagent;Research;Research Design;Research Personnel;Resolution;Resources;Scientist;sensor;Services;Signal Pathway;Standardization;Substance abuse problem;Substance Use Disorder;success;Synapses;tool;Training;Training and Education;Transgenic Mice;Transgenic Organisms;Translations;two-photon;undergraduate student;Universities;vector;Viral;Viral Vector;virus genetics;Virus Integration;Washington;Work

PROJECT_TITLE: Molecular Genetics Resource Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-D (M1)]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

PI_NAMEs: CHAVKIN, CHARLES  (contact)

PROJECT_TERMS: Address;Adherence;Applications Grants;Award;Budgets;Conflict of Interest;data acquisition;Data Analyses;design;Ensure;Equipment;Exclusion;Funding;Funding Mechanisms;Genetic Research;Grant;high risk;IACUC;Image;imaging genetics;Imaging Techniques;Individual;innovation;large datasets;Machine Learning;Manuscripts;Molecular Genetics;Monitor;National Institute of Drug Abuse;National Research Service Awards;neural circuit;Operative Surgical Procedures;Opiate Addiction;opioid use disorder;Participant;Pilot Projects;programs;Progress Reports;Publications;Reporting;Reproducibility;Research;Research Personnel;Research Support;Resources;Series;skills;Statistical Methods;Supervision;Training;Training Programs;training project;United States National Institutes of Health;Universities;Washington;Writing

PROJECT_TITLE: Pilot Project Core


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: KINGSVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TEXAS A&M UNIVERSITY-KINGSVILLE

ORG_STATE: TX

PHR: The fields of venom and anti-venom research are absolutely dependent on access to the reliable and reproducible venom-related resources developed by the National Natural Toxin Research Center (NNTRC). Snake venoms have provided molecular probes that have been used to decipher numerous complex physiological and pathophysiological processes and have served as the starting point for the development of several important classes of drugs. In addition, antibody-based anti-venoms, whose production and profiling depends on the well- characterized venoms produced by the NNTRC, serve as the mainstay in the treatment of both human and veterinary snakebite.

PI_NAMEs: SANCHEZ, ELDA E. (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Address;American;Animals;Antibodies;Antivenins;Applied Research;Basic Science;Biocompatible Materials;Biological Assay;biological research;Biomedical Research;Cell Surface Receptors;Cells;Clinical Research;Collection;Complex;Crotalid;Development;Didelphidae;Discipline;Evolution;experience;Faculty;Funding;Genomics;Goals;Grant;Growth;Health;Human;IACUC;improved;In Vitro;Individual;interest;International;Methods;Military Personnel;Molecular Probes;Monodelphis Domestica;Neotomas;next generation;Nociception;novel;novel drug class;novel therapeutics;outreach program;Pharmaceutical Preparations;Physiological;Play;Process;Production;programs;Proteins;Proteomics;Provider;Recombinants;Reproducibility;Research;Research Personnel;Resistance;Resources;Role;Scientist;service programs;Services;skills;Snake Venoms;Snakes;Source;Specificity;Testing;Texas;Therapeutic;Toxin;Toxinology;Training;transcriptomics;Translational Research;Underrepresented Students;United States National Institutes of Health;Universities;Venoms

PROJECT_TITLE: Viper Resource Grant at Texas A&M University-Kingsville

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-C (56)]


NIH_SPENDING_CATS: Clinical Research

PROJECT_TERMS: American;Antivenins;Area;Award;Awareness;base;biological research;Biomedical Research;career;Collection;Communities;community engagement;Education;Education and Outreach;Funding;Goals;Grant;Growth;Health Occupations;Heart;Income;innovation;Institution;International;Letters;Marketing;minority student;Minority-Serving Institution;Modeling;novel therapeutics;Occupational activity of managing finances;operation;outreach program;Paper;Performance;programs;Proteins;Recombinants;Reproducibility;Research;Research Infrastructure;Research Support;Resources;Scientist;service programs;Services;skills;Snake Venoms;Snakes;Societies;sound;Source;STEM research;Talents;Texas;Time;Toxin;Toxinology;Universities;Venoms


PROJECT_TERMS: acquired immunity;Animals;Antibodies;Antidotes;Antivenins;Applied Research;aptamer;Area;Biological Assay;Biological Products;Blood Vessels;Cell-Mediated Cytolysis;Cells;Cessation of life;Communities;crosslink;Crotalid;Crotalus;Development;Didelphidae;effective therapy;extracellular vesicles;Fractionation;Functional disorder;Genomics;global health;Goals;Grant;Hemorrhage;Hemostatic function;improved;In Vitro;inhibitor;interest;Lymphatic;Mammals;Medical;Methods;Molecular;molecular marker;Monodelphis Domestica;Morbidity - disease rate;mortality;Natural Products;Natural Resistance;Neotomas;new therapeutic target;next generation;novel;novel strategies;Permeability;Pharmaceutical Preparations;Post-Translational Protein Processing;Production;programs;Proteins;Proteomics;Recombinant Proteins;Recombinants;Recording of previous events;Reporting;Research;Resistance;Resources;response;screening;Serum;Services;Signal Pathway;Snake Bites;Snake Venoms;Snakes;Technology;Testing;Texas;Therapeutic;Thrombosis;Time;tool;Toxicity Tests;Toxin;transcriptome sequencing;Universities;Validation;Venoms;World Health Organization


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Data, the building blocks of knowledge, are becoming ubiquitous in all areas of health sciences, particularly cancer research. The Quantitative Sciences Undergraduate Research Experience at Memorial Sloan Kettering Cancer Center uses a multi-pronged approach integrating research, education, and career/professional development to help reinforce students’ professional goals and prepare them to become strong quantitative scientists dedicated to advancing cancer research.

PI_NAMEs: BEGG, COLIN B (contact);DU, MENGMENG ;TAN, KAY SEE

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Active Learning;Address;Advanced Malignant Neoplasm;Advertising;American;anti-cancer research;Area;Behavioral;Big Data;Biometry;Cancer Patient;career;Characteristics;Clinical;cohort;Communication;Communities;Competence;Comprehensive Cancer Center;curriculum enhancement;Data;Data Collection;Dedications;design;Development;Dimensions;Doctor of Philosophy;Education;Educational Curriculum;Educational workshop;Environmental Exposure;epidemiologic data;Epidemiology;equity, diversity, and inclusion;Ethics;Etiology;Event;experience;Face;Faculty;faculty mentor;Family;Feedback;Funding;global health;Goals;Guidelines;hands on research;Health;Health Sciences;High School Student;Historically Black Colleges and Universities;improved;Individual;Inherited;innovation;insight;Internships;Knowledge;Malignant Neoplasms;Memorial Sloan-Kettering Cancer Center;Mentors;Methodology;mobile computing;Modeling;Molecular;Morbidity - disease rate;mortality;New York City;next generation;Nigerian;novel;Oncology;Online Systems;Oral;Outcome;outreach;patient oriented;Patients;peer;Peer Review;Persons;Population;professional students;programs;Publications;Published Comment;Publishing;real world application;recruit;Reporting;Research;Research Training;resilience;responsible research conduct;Role;satisfaction;Science;Scientist;Series;skills;Students;success;Surveys;symposium;System;Technology;Training;tribal college;tumor progression;undergraduate research experience;undergraduate student;Underrepresented Students;underserved community;United States;Work;Writing

PROJECT_TITLE: Quantitative Sciences Summer Undergraduate Research Experience (QSURE)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Homelessness among Veterans is a priority at the national level, and the VA has made substantial progress recently in housing homeless Veterans. However, permanent housing is a necessary, but not sufficient, condition for successful community integration. Community integration (e.g., social contact with friends / family; capacity for work / productive activities) is essential for long-term health outcomes, but it does not arise automatically once housing is received. This RR&D Center based at the VA Greater Los Angeles will support an interdisciplinary team of investigators and research projects, and its overarching goal is to understand and improve community integration for homeless and recently-housed Veterans. This will be done through three research focus area: 1) To develop and validate innovative assessments relevant to community integration, 2) To identify determinants that predict improvements in community integration, and 3) To develop and adapt interventions to enhance community integration for homeless and recently-housed Veterans.

PI_NAMEs: GABRIELIAN, SONYA EMI;GREEN, MICHAEL F. (contact);MARDER, STEPHEN R

PROJECT_TERMS: Area;Award;Clinical;Clinical assessments;Cognition;Cognitive;Communities;Community Integration;data management;Dissemination and Implementation;experience;Family;Fellowship Program;Friends;Goals;Grant;Health;Health Services;Homeless persons;Homelessness;Housing;improved;innovation;Intervention;Intervention Studies;Link;Los Angeles;Measures;Methods;Mission;Motivation;neglect;novel;Outcome;Pathway interactions;Pharmaceutical Preparations;Population;Postdoctoral Fellow;Predictive Factor;Procedures;Process;Productivity;programs;Psyche structure;psychosocial;Recovery;recruit;Research;Research Personnel;Research Project Grants;Risk;Sampling;Services;skills;social;social contact;social integration;statistics;Technology;therapeutic target;Translational Research;Veterans;Work

PROJECT_TITLE: Enhancing Community Integration for Homeless Veterans

STUDY_SECTION: RRDC

STUDY_SECTION_NAME: Centers, Research Enhancement Award Program and Consortiums[RRDC]


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Typically, rehabilitation is prescribed to improve physical functioning among Veterans recovering from an illness, injury or surgery. It is rarely viewed as a mode of preventative care. However, the average age of US Veterans is 64 years old; and when compared to civilians of the same age, Veterans are more functionally impaired. This puts Veterans at high risk for loss of independence, low motivation and poor quality of life. Therefore, to better serve aging Veterans, we must identify treatments that improve health and independence across the lifespan. We will create a center that focuses on preventative rehabilitative care, which is also known as Prehabilitation. Our Prehabilitation research center will develop personalized treatments that target physical function, cognition and motivation, that can be spread throughout VHA.

PI_NAMEs: BEAN, JONATHAN F (contact);CHECKO (SCIOLI), ERICA ROSE;MOY, MARILYN L.

PROJECT_TERMS: Achievement;Activities of Daily Living;Age;Aging;bean;behavior change;Behavioral;Biological;Biometry;Caring;Chronic Disease;Clinical Research;Cognition;cognitive function;Collection;complex data;Data;data management;data repository;data resource;Databases;design;Development;disability;Disability prevention;Educational Activities;efficacy testing;Faculty;functional decline;functional disability;Functional impairment;Goals;Grant;Habilitation;Health;Health Care Costs;health care service utilization;high risk;Ideal 1;Impairment;improved;Injury;investigator training;Knowledge;Leadership;life span;Link;Measures;Mediating;meetings;Mind;Modeling;Monitor;Motivation;Neurocognitive;novel therapeutic intervention;operation;Operative Surgical Procedures;Outcome;Patients;personalized medicine;Phenotype;Physical Function;Pilot Projects;Play;Prevention;Preventive care;Preventive treatment;programs;promote resilience;Qualifying;Quality of life;Rehabilitation therapy;rehabilitative care;Research;Research Design;Research Personnel;Resources;Risk;Role;success;Testing;Therapeutic;Training and Education;treatment response;Veterans

PROJECT_TITLE: REhabilitation Promoting Prevention And Improved Resilience (REPPAIR)


ORG_CITY: GAINESVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: FL

PHR: Veterans with central nervous system injury or diseases such as traumatic brain injury (TBI) or stroke commonly develop chronic disabilities affecting cognitive, motor, and emotion function. Costs for neurologic- related care will likely increase; for example, some estimate that costs to treat stroke alone may double by 2030. Besides the mounting costs, these disabilities worsen quality of life. The purpose of the Brain Rehabilitation Research Center is to identify mechanisms and discover treatments to restore function and enhance quality of life. The BRRC neurorehabilitation portfolio promotes neuroplasticity that drives optimal recovery of emotion, memory, attention, executive control, mobility, gait coordination, and upper limb function, thereby improving the health and well-being of Veterans. Research results will inform and help transform clinical practice, which ultimately enables the VA health system to provide more cost effective and better long- term care for Veterans with neurological injury or disease.

PI_NAMEs: BOSE, PRODIP K. (contact);TRIGGS, WILLIAM J

PROJECT_TERMS: Achievement;Affect;Age;Animal Model;Attention;Award;Benchmarking;Brain;Brain imaging;Budgets;career;Caring;central nervous system injury;Chronic;Chronic disability;chronic stroke;Clinical;clinical practice;clinical translation;Cognition;Cognitive;cognitive recovery;Collaborations;comorbidity;comparative effectiveness trial;cost;cost effective;cost estimate;Diagnosis;disability;Disease;efficacy evaluation;emotion regulation;Emotional;Emotions;Equipment;Ethnic Origin;Etiology;executive function;falls;feasibility testing;Feedback;Florida;Fright;functional restoration;Funding;Gait;gait rehabilitation;Gender;Genetic Markers;genetic variant;Goals;Health;Health system;Healthcare;Healthcare Systems;Hospitals;Human;human model;Impaired cognition;improved;Inflammatory;innovation;Institution;Interdisciplinary Study;Intervention;Leadership;Locomotor training;Long-Term Care;Measurement;Measures;Memory;Memory impairment;Mentors;Mission;Motor;motor recovery;multiple disability;Nervous System Disorder;Nervous System Trauma;neural;neural network;Neurodegenerative Disorders;Neurologic;neurological rehabilitation;Neuronal Plasticity;neurophysiology;Neurosciences;novel;Organizational Models;Pathologic;Pathology;Performance;persistent symptom;Personal Satisfaction;post stroke;Post-Traumatic Stress Disorders;pre-clinical;Process;program dissemination;programs;Protocols documentation;Psychotherapy;Quality of life;Race;Recovery;Regimen;rehabilitation research;Rehabilitation therapy;Research;Research Personnel;Resource Sharing;Resources;response;Rodent Model;Role;Science;Self Efficacy;sensory feedback;Services;Strategic Planning;Stroke;stroke intervention;stroke survivor;stroke therapy;Structure;Survivors;Testing;Time;Training;Traumatic Brain Injury;Universities;Upper Extremity;Upper limb movement;Veterans;Walking

PROJECT_TITLE: Brain Rehabilitation Research Center


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The proposed research is relevant to public health because it focuses on developing a new, alternative strategy for treating individuals with mood, anxiety, and traumatic stress disorders. This treatment is designed to improve cognitive functioning by using a computer-based training program that has the potential to be a low cost and portable option. Developing this new treatment approach aligns with the NIMH’s mission to create novel, targeted interventions with the potential to improve cognitive and emotional function for individuals with these highly prevalent conditions.

PI_NAMEs: BOMYEA, JESSICA  (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Address;Adult;adverse outcome;Affect;Anxiety;associated symptom;Behavioral;Benchmarking;Brain;Cellular Phone;Clinical;clinical effect;Cognition;Cognitive;cognitive enhancement;cognitive function;cognitive performance;cognitive system;cognitive task;cognitive testing;Cognitive Therapy;cognitive training;computerized;confirmatory trial;cost;Data;design;Diagnostic;disability;Disease;Distress;Dose;E-learning;efficacy evaluation;emotional functioning;emotional symptom;Environment;Executive Dysfunction;executive function;Exercise;experience;Foundations;Frequencies;Goals;improved;Individual;innovation;Intervention;Knowledge;Memory;Mental Depression;mHealth;Mission;Modeling;mood symptom;Moods;National Institute of Mental Health;negative mood;neural;Neurobehavioral Manifestations;Neurobiology;neuroimaging;Neurosciences;novel;novel therapeutic intervention;Outcome;Participant;Performance;Persons;Phase;Population;portability;Post-Traumatic Stress Disorders;primary outcome;psychologic;Public Health;Randomized;Randomized, Controlled Trials;reduce symptoms;Research;Research Priority;Resources;Role;rumination;Sampling;Short-Term Memory;standard care;stem;suicidal risk;Symptoms;System;Task Performances;Testing;Therapeutic;Thinking;tool;Training;Training Programs;Training Technics;Traumatic Stress Disorders;treatment program

PROJECT_TITLE: Enhancing transdiagnostic mechanisms of cognitive dyscontrol using computer-based training


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Borderline Personality Disorder (BPD), a prevalent psychiatric disorder characterized by poorly regulated emotion and found in approximately 2% to 6% of the population and 20% of hospitalized psychiatric patients, has proven quite treatment resistant. In additional to the 10% suicide rate, the emotional costs of the suffering experienced by borderline patients and their loved ones, BPD patients typically consume a disproportionate share of mental health resources. This study is innovative in testing, by means of brain imagng and clinical measures, a new short-term approach to treatment, based upon focused cognitive training to improve the ability to regulate emotion.

PI_NAMEs: KOENIGSBERG, HAROLD W (contact)

PROJECT_TERMS: Address;Adherence;Affect;Affective;Amygdaloid structure;Anger;associated symptom;Aversive Stimulus;behavior measurement;Behavioral;behavioral response;Borderline Personality Disorder;Brain;Chronic;Clinical;clinical outcome measures;clinically relevant;Cognitive;cognitive enhancement;cognitive reappraisal;cognitive training;Consumption;cost;design;Development;Disabling;disabling symptom;Disease;dosage;Dose;Educational Intervention;Effectiveness;emotion dysregulation;emotion regulation;Emotional;emotional experience;Emotions;Event;Evidence based treatment;experience;Exposure to;follow-up;functional improvement;Functional Magnetic Resonance Imaging;functional outcomes;health care service;Health Resources;healthcare burden;Image;Impairment;improved;Impulsivity;innovation;inpatient psychiatric treatment;interest;Intervention;Lead;Life;loved ones;Manuals;Measures;Mental disorders;Mental Health;Methods;Moods;neural;neural circuit;neural network;neuroregulation;novel strategies;Outcome;Patients;perceived stress;Performance;Pharmaceutical Preparations;Phase;Population;Prevalence;psychosocial;Psychotherapy;Reaction;reduce symptoms;Regulation;Reporting;Reproducibility;Research;Resistance;Resources;response;Role;Sampling;Severities;social;Stimulus;success;suicidal;suicidal risk;suicide rate;Symptoms;System;Testing;Therapeutic Intervention;Time;Training;Training Programs;Translating;treatment effect;treatment optimization;Work

PROJECT_TITLE: Cognitive Reappraisal Training Targeting Emotion Circuits As a Therapeutic Intervention in Borderline Patients


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric

ORG_CITY: HARTFORD

ORG_NAME: HARTFORD HOSPITAL

ORG_STATE: CT

PHR: This R61/R33 proposal is based on converging evidence that suggests prior ADHD working memory training studies might have produced lackluster clinical outcomes because they focused on enhancing the wrong cognitive and neurobiological targets. The proposed studies will assess whether or not a novel executive working memory training intervention for Attention-Deficit/Hyperactivity Disorder can engage frontoparietal brain network treatment targets and behavioral performance (R61), then replicate target engagement while also determining if it correlates with clinically meaningful improvements in ADHD dysfunction (R33). The project was designed so that if the R61/R33 aims are successful, the data we obtain will be adequate to support a future preliminary efficacy clinical trial.

PI_NAMEs: STEVENS, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: Access to Information;Adolescent;Attention deficit hyperactivity disorder;Behavior;Behavior Control;Behavioral;behavioral impairment;Belief;Brain;brain dysfunction;Brain region;Clinical;Clinical Trials;clinically relevant;Cognitive;cognitive control;cognitive process;cognitive training;cohort;computerized;Control Groups;Data;design;Diagnosis;Disease;distraction;Educational Intervention;effective intervention;efficacy clinical trial;efficacy study;efficacy testing;efficacy trial;Equipment and supply inventories;Etiology;Exercise;expectation;flexibility;Foundations;Functional disorder;Functional impairment;Functional Magnetic Resonance Imaging;Future;group intervention;Home;Impairment;improved;Individual;interest;Intervention;Investigational Therapies;Lateral;Learning;Left;Link;Maintenance;Measures;mental representation;Meta-Analysis;Mind;Modeling;National Institute of Mental Health;neural;neural correlate;Neurobiology;neuroimaging;Neuronal Dysfunction;Neuronal Plasticity;Neurosciences;novel;operation;Outcome;Outcome Measure;Participant;Patients;Performance;Phase;Pilot Projects;Placebos;Prefrontal Cortex;Process;Publishing;Randomized;randomized placebo controlled trial;randomized, clinical trials;reduce symptoms;Research;Research Personnel;secondary analysis;selective attention;Series;Severities;Short-Term Memory;success;superior frontal sulcus;symptomatic improvement;Symptoms;Testing;therapy development;Training;Update

PROJECT_TITLE: Behavioral and Neural Target Engagement for ADHD Executive Working Memory Training


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: COLLEGE PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE This proposal aims to characterize the neuro-computational mechanisms that drive human social learning, and their alterations in relation to trans-diagnostic symptom dimensions relevant to psychopathology. Social learning computations will be examined both in the general population and in autism, a neuro-developmental disorder known to be associated with deficits in social function. In the long run, this research has the potential to inform the development of more tailored clinical assessments and interventions to improve social function in mental health.

PI_NAMEs: CHARPENTIER, CAROLINE JULIETTE (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Address;Affect;Anxiety;autism spectrum disorder;autism symptoms;Award;Bayesian Method;Behavior;Behavioral;Belief;Biological;Birth;Brain;Clinical;Clinical assessments;Clinical Treatment;clinically relevant;cognitive ability;cognitive neuroscience;cohort;Collaborations;Communication;comorbidity;computer framework;Computer Models;Computing Methodologies;Data;Development;Diagnosis;Diagnostic;diagnostic strategy;dimension reduction;Dimensions;Disease;Ensure;Environment;Exhibits;experience;experimental study;Functional disorder;Functional Magnetic Resonance Imaging;General Population;Goals;Human;Impairment;improved;Individual;Individual Differences;individuals with autism spectrum disorder;information gathering;innovation;Intervention;Knowledge acquisition;learned behavior;Learning;learning ability;Life;Link;Machine Learning;Measures;Mental disorders;Mental Health;Mentorship;Methodology;Methods;Modeling;Moods;neural;Neurodevelopmental Disorder;neuroimaging;Neurosciences Research;news;novel;Parameter Estimation;Participant;Pathway interactions;Patient Recruitments;Patient Self-Report;Pattern;Phase;Policies;Population;Process;psychiatric symptom;Psychiatry;Psychopathology;Research;Resource Sharing;Sampling;skills;social;social anxiety;social deficits;Social Functioning;social group;social influence;social integration;Social Interaction;social learning;social media;social situation;social skills;Symptoms;Techniques;Testing;Time;Training;trait;Trust;Update;Variant;Withdrawal;Work

PROJECT_TITLE: Neuro-computational mechanisms of social learning and variation along psychiatric symptom dimensions and in autism


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Recurrent glioblastoma is associated with poor response to immunotherapy due in part to the immune- suppressive tumor microenvironment. Localized interleukin 12 (IL12) is making progress in therapy for malignant brain tumors by triggering anti-tumor immunity in patients. Our proposal will study IL12-induced anti- and pro-tumoral signaling in GB mouse models and develop a next-generation treatment whereby multi-factorial nanocarriers (extracellular vesicles) sustain IL12-triggered immunomodulating effects.

PI_NAMEs: BREYNE, KOEN  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Address;Adopted;Antibodies;antitumor effect;attenuation;Automobile Driving;Biology;brain cell;Brain Glioblastoma;Brain Neoplasms;career;career development;CD8B1 gene;Cell Line;Cells;Clinical;Clinical Research;Clinical Trials;clinically relevant;Combined Modality Therapy;Complex;cytokine;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;design;Development;Development Plans;Educational workshop;Engineering;Environment;experimental study;Exposure to;extracellular;extracellular vesicles;Faculty;fitness;Flow Cytometry;Foundations;Glioblastoma;Glioma;Goals;Immune;Immunity;immuno-gene therapy;Immunochemistry;Immunooncology;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;Infiltration;Integral Membrane Protein;Interferon Type II;Interleukin-12;Interleukin-12 therapy;K22 Award;Label;Leadership;Lentivirus Vector;Life Expectancy;Lymphocyte Function;Macrophage;Malignant neoplasm of brain;Mediating;Membrane Proteins;Mentors;MHC antigen;Microglia;Modality;Modeling;Monitor;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;nanocarrier;neoantigens;neoplastic cell;Newly Diagnosed;next generation;Oncogenic;Paper;Patients;Phase;Positioning Attribute;Production;programmed cell death ligand 1;programs;Recombinants;Recurrence;Relapse;release factor;Research;Resistance;resistance mechanism;Resolution;response;Signal Transduction;single-cell RNA sequencing;Site;small molecule;Source;symposium;System;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;Time;Training;Transforming Growth Factors;Transgenic Mice;Transgenic Model;Translating;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;tumorigenic;vector;Work;Writing

PROJECT_TITLE: Boosting IL-12-induced anti-glioblastoma activity via immunotherapeutic extracellular vesicles.

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (M1)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative Approximately 17 million adults in the US are currently diagnosed with an alcohol use disorder (AUD), and about 95,000 people die from alcohol-related causes annually, making alcohol the third leading preventable cause of death in the US. Alcohol is a social drug and is believed to affect interpersonal processes in ways that might contribute to the development and maintenance of AUD. This project aims to better understand AUD risk within close social relationships by focusing on how poor relationship quality impacts the experience of alcohol intoxication in ways that reinforce drinking and increase risk to develop alcohol problems.

PI_NAMEs: CRESWELL, KASEY G. (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Acute;Adult;Affect;aged;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol reinforcement;alcohol relapse;alcohol related problem;alcohol risk;alcohol sensitivity;alcohol use disorder;Alcoholic beverage heavy drinker;Alcoholic Intoxication;Alcohols;Behavioral;Beverages;binge drinking;Blood;Cause of Death;Clinical;Conflict (Psychology);conflict resolution;Consumption;Couples;Couples Therapy;Development;Diagnosis;disorder risk;Distress;Dose;drinking;drinking behavior;Ecological momentary assessment;Emotional;Exhibits;experience;Facial Expression;Female;follow-up;Frequencies;Heavy Drinking;improved;Individual;insight;Intervention;Knowledge;Laboratories;Laboratory Study;Lead;Life;Limb structure;Link;Literature;Longterm Follow-up;Maintenance;male;Measures;member;Methodology;Modeling;Moods;negative affect;next generation;novel;Outcome;Patient Self-Report;Persons;Pharmaceutical Preparations;Placebos;Prevention;Prevention program;Process;prospective;Psychological reinforcement;Psychological Theory;Psychologist;Reporting;Research;response;Rewards;Risk;Risk Factors;Sample Size;Shapes;social;social attachment;social cohesion;social relationships;Speech;Study models;success;Symptoms;System;Testing;Theoretical model;Time;tool;Translating;translational impact;treatment effect;Treatment outcome;Work;young adult

PROJECT_TITLE: Close Relationships and Alcohol Use Disorder Risk

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Climate-Related Exposures and Conditions;Lung;Social Determinants of Health

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: PROJECT NARRATIVE Repetitive ozone exposures result in mucoinflammatory respiratory responses that are also associated with allergic asthma. Thus, the sustained ozone pollution during the resolution phase of allergic asthma may disrupt restoration of tissue structure and function. Using innovative approaches, supported by our novel and exciting data, we will study the effect of ozone pollution on the resolution of allergen-induced asthmatic inflammation that will also include genetic and pharmacological strategies to neutralize the proinflammatory/anti-resolution effect of ozone-mediated disruptions in the resolution of allergic respiratory disease.

PI_NAMEs: SAINI, YOGESH  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Ablation;Address;Air Pollution;airway epithelium;airway inflammation;Allergens;Allergic;allergic airway inflammation;Allergic inflammation;Alveolar Macrophages;Anti-Inflammatory Agents;Antiinflammatory Effect;Apoptosis;Asthma;asthmatic;autocrine;Bone Marrow;Cell Lineage;Cell Physiology;Cells;Cellular Structures;Chimera organism;Data;Development;Disease;efficacy testing;Epithelial Cells;Expeditions;Exposure to;Extrinsic asthma;Female;Genetic;Genotype;Germ Lines;granulocyte;Hematopoietic;Hematopoietic stem cells;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;innovation;Interleukin Receptor;Interleukins;Kinetics;Knowledge;Lung;male;Mediating;Messenger RNA;Metaplasia;Modeling;Molecular;Mucous body substance;Mus;Nose;novel;Ozone;ozone exposure;paracrine;Pathogenesis;pharmacologic;Phase;Play;Pollution;pulmonary function;Pulmonary Inflammation;recruit;repaired;Resolution;respiratory;Respiratory Disease;Respiratory System;response;restoration;Rodent;Role;Signal Transduction;Structure;Tamoxifen;Testing;Therapeutic;Tissues;translational impact;Up-Regulation

PROJECT_TITLE: Targeting Type-2 mucoinflammatory axis during the resolution of allergic lung inflammation

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Primary Health Care;Rehabilitation;Sleep Research;Social Determinants of Health

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Insomnia is prevalent sleep disorder, with highest rates among low-income adults, which is a risk factor for a host of physical and mental health conditions. This study aims to compare how well two, proven non-drug treatments treat insomnia in 350 adults of lower income and/or racial and ethnic minority groups seen in primary care. This study will inform future studies designed to test the best strategies to make these treatments more available for underserved patients with insomnia in primary care and thereby improve health.

PI_NAMEs: BERTISCH, SUZANNE  (contact)

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: Abbreviations;acceptability and feasibility;Address;Administrator;Adoption;Adult;Adverse event;adverse outcome;arm;Behavior Therapy;Behavioral;Biometry;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;Caring;Clinic;Clinical;Clinical Research;Clinical Trials;Cognitive Therapy;Communities;Consolidated Framework for Implementation Research;contextual factors;cost;Data;Data Collection;Diagnosis;diaries;Disparity;Dissemination and Implementation;Economically Deprived Population;effectiveness testing;effectiveness-implementation randomized trial;effectiveness/implementation trial;Eligibility Determination;Employee;Ensure;ethnic minority;ethnic minority population;evidence base;Evidence based treatment;experience;Foundations;Future;future implementation;Goals;Guidelines;Health;health inequalities;health related quality of life;Hospitals;Hour;Household;hypnotic;Impaired cognition;Impairment;implementation determinants;implementation science;implementation trial;improved;Income;indexing;Inequity;informant;Infrastructure;Insurance;Intervention;Interview;Knowledge;Language;Low income;Low Income Population;Major Depressive Disorder;Medicaid;Medical;Medical Assistance;medical specialties;Mental Depression;Mental Health;Modeling;mortality;multidisciplinary;Nonpharmacologic Therapy;Nurse Practitioners;Outcome;Participant;patient population;Patients;payment;Persons;Pharmacotherapy;Phase;physical conditioning;Physician Executives;pilot test;post intervention;Premature Mortality;Preventive;Primary Care;primary care clinic;primary care patient;primary care setting;primary outcome;programs;Protocols documentation;Quality of life;racial minority;racial minority population;randomized effectiveness trial;randomized trial;Recommendation;Recording of previous events;recruit;Reporting;Research;Research Design;Risk;Risk Factors;Sampling;secondary outcome;Severities;side effect;Site;Sleep;Sleep Disorders;sleep health;sleep onset;sleep quality;Sleeplessness;Social Workers;socioeconomic disadvantage;Spanish;Structure;Symptoms;telehealth;Telephone;Testing;Time;Training;treatment comparison;trial enrollment;Underserved Population;United States;uptake;Woman;Work

PROJECT_TITLE: A hybrid effectiveness-implementation trial evaluating behavioral treatments for insomnia for socioeconomic disadvantaged adults in primary care

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


ORG_CITY: ANN ARBOR

ORG_STATE: MI

PHR: Cryptococcus is a ubiquitous fungal pathogen which causes substantial morbidity and mortality in Veterans and other patients worldwide. Veterans have increased risk of infection due to higher rates of immunocompromising medical conditions relative to the general population (HIV and use of immune suppressive therapies). Current therapies for patients infected with Cryptococcus are lengthy, highly toxic, often ineffective, and may actually contribute to inflammatory complications. These complications are linked to pathological brain damage, mortality, and/or development of lasting disabilities in these patients. This proposal will study immune mechanisms preventing detrimental immune responses during cryptococcal CNS infection and explore immunotherapeutic potential of regulatory T cells in a relevant animal model. Our results will be also relevant to other CNS infections caused by pathogens to which Veterans are exposed to during deployment (malaria, tuberculosis meningitis and CNS viruses).

PI_NAMEs: OLSZEWSKI, MICHAL A (contact)

PROJECT_TERMS: Acceleration;Adoptive Transfer;Affect;Amphiregulin;Animal Model;Animals;anti-fungal agents;Anti-Inflammatory Agents;Antifungal Therapy;Antigen-Antibody Complex;biomarker identification;Brain;Brain Injuries;CCL1 gene;CCR8 gene;Cellular immunotherapy;Central Nervous System;Central Nervous System Fungal Infections;Central Nervous System Infections;central nervous system injury;Cessation of life;chemokine;chemokine receptor;combat;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;cytokine;Cytoprotection;Data;Dependence;Deterioration;Development;disability;Disease;Elements;Epidermal Growth Factor;experience;experimental study;Exposure to;Functional disorder;fungus;General Population;Goals;HIV;Homeostasis;Human;Immune;Immune response;Immunity;Immunocompromised Host;immunomodulatory therapies;immunopathology;immunoregulation;immunostimulatory therapy;Immunosuppression;Immunotherapeutic agent;improved;Infection;infection risk;Inflammation;Inflammatory;Inflammatory Response;insight;Interleukin-10;Interleukin-2;Investigation;Kinetics;Knockout Mice;Ligands;Link;Lung;Malaria;Mediating;Medical;Meningeal Tuberculosis;Meningoencephalitis;Methods;migration;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Nervous System Physiology;Nervous System Trauma;Neurologic;Neurologic Symptoms;neuropathology;novel therapeutic intervention;pathogen;Pathogenesis;pathogenic fungus;Pathologic;Pathology;Patients;Pharmacotherapy;Play;Population;pre-clinical;prevent;Process;Production;protective effect;Publishing;recruit;reduce symptoms;Regulation;Regulatory T-Lymphocyte;repaired;Reporting;Research;response;Role;Series;System;T cell response;T cell therapy;T-Cell Depletion;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;tissue repair;translation to humans;Up-Regulation;Veterans;Virus;wound healing

PROJECT_TITLE: Immunoregulatory Mechanisms to Combat CNS Pathology During Infection


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: PTSD is 3-4 times more prevalent in Veterans than in the general population, and this gap is anticipated to increase due to ongoing conflict extensions and prolonged, repeated deployments. PTSD has been described as a “life sentence due to its association with increased risk of chronic disease, accelerated aging, and premature mortality.” Meta analyses suggest that low bone mass (osteopenia) and osteoporosis are significant comorbidities for patients with PTSD. Our preliminary data in a pre-clinical model of PTSD supports the hypothesis that PTSD-related bone loss is due to an imbalance between bone building cells (osteoblasts) and bone resorbing cells (osteoclasts) and that SHP2 mediates this osteoblast-osteoclast dysregulation. Herein, we will determine the cellular and molecular mechanisms driving PTSD-related bone loss and investigate novel methods for mitigating these negative bone effects. This proposal employs innovative approaches and has significant clinical impact for Veterans by identifying PTSD as a critical risk factor for bone morbidities.

PI_NAMEs: LARUE, AMANDA C. (contact)

PROJECT_TERMS: Acceleration;Address;adjudication;Affect;age acceleration;Amendment;Animals;Attention;Automobile Driving;Awareness;biomechanical test;Biomechanics;bisphosphonate;bone;Bone Density;Bone Diseases;bone health;bone loss;bone mass;Bone Resorption;bone turnover;cell type;Cells;Characteristics;Chronic Disease;Classification;Clinical;clinical practice;Clinical Trials;clinically relevant;comorbidity;Comprehensive Health Care;conditioned fear;Conflict (Psychology);Data;Development;Diagnosis;Diagnostic Procedure;Disease;Disparity;DSM-V;Equilibrium;Etiology;Event;Exhibits;experience;Face;Female;Flow Cytometry;Fracture;fracture risk;Freedom;General Population;Gulf War veteran;Health;Hematopoietic stem cells;high risk;Histology;Immunohistochemistry;improved;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;inhibitor;innovation;insight;Knowledge;Life;Link;Maintenance;male;mechanical properties;Mediating;Mediator;MEKs;Mental Health;mesenchymal stromal cell;Meta-Analysis;Methods;microCT;Modeling;Modification;Molecular;Monitor;Morbidity - disease rate;mouse model;Mus;Musculoskeletal Diseases;neurogenesis;Neuropeptides;neurotrophic factor;new therapeutic target;novel;operation;osteoblast differentiation;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteocytes;Osteogenesis;osteogenic;Osteopenia;Osteoporosis;osteoprogenitor cell;Pathologic;Pathway interactions;Patients;pharmacologic;Phenotype;Physiological;PI3K/AKT;Play;Post-Traumatic Stress Disorders;pre-clinical;Pre-Clinical Model;Premature Mortality;Prisoner;progenitor;Proliferating;Property;protein phosphatase inhibitor-2;Protein Tyrosine Phosphatase;recruit;Regulation;Reporting;Risk;Risk Factors;Role;Services;Sex Differences;Signal Pathway;Signal Transduction;skeletal;Skeletal system;Source;standard of care;stem cells;substantia spongiosa;Symptoms;Testing;traumatic event;Veterans;Vietnam;War;wound

PROJECT_TITLE: Exposing Invisible Wounds: Impacts of PTSD on Bone Health


PHR: Even though there are astrocytes in the brain, and they outnumber neurons, current circuit models of sleep-wake regulation continue to be “neuron-centric”. We will use the microendoscopy method to measure changes in fluorescence in individual astrocytes and neurons in a deep-brain region implicated in sleep. The data will describe a more complete network model of sleep regulation that will aid in strategies to treat insomnia.

PI_NAMEs: SHIROMANI, PRIYATTAM J. (contact)

PROJECT_TERMS: Action Potentials;active control;Alzheimer's Disease;American;Area;Astrocytes;Automobile Driving;Behavior;Brain;Brain region;Calcium;Cells;Data;Dendrites;Deterioration;excitatory neuron;experimental study;falls;Female;Fiber;Fluorescence;Funding;gamma-Aminobutyric Acid;Glial Fibrillary Acidic Protein;Glucose;Glutamate Transporter;Glutamates;glymphatic system;Homeostasis;Human;Image;In Vitro;in vivo;indexing;Individual;inhibitory neuron;Link;Lipids;male;Measures;Memory;Methodology;Methods;microendoscopy;Modeling;Monitor;Moods;Mus;network models;Neurobiology;Neuroglia;Neurons;non rapid eye movement;Nutrient;Opsin;optogenetics;Pattern;Pharmacogenetics;Photometry;Posterior Hypothalamus;Rattus;redshift;Refuse Disposal;Regulation;REM Sleep;Research Personnel;response;sensor;Sleep;Sleep Deprivation;Sleep Disorders;sleep regulation;Sleeplessness;Slice;Synapses;Synaptic Transmission;Testing;Time;tool;transcription factor;wasting;Waxes;zona incerta

PROJECT_TITLE: Sleep Neurobiology and Circuitry


FUNDING_MECHANISM: OTHERS

ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: The PI studies DNases, the enzymes which fragment DNA during any organ or tissue injury: chemical or drug poisoning, radiation, hypoxia, cancer or atherosclerosis. The mechanisms and role of the DNA fragmentation is not known, and, more importantly, no protection against DNases, is available. The PI’s research determines the DNase mechanisms and develop new DNase inhibitors which have a great promise to be used as universal drugs to ameliorate human diseases, including cancer and atherosclerosis, organ chemical injuries and traumas, as well as toxic side effects of drugs. These studies are highly relevant to the VA healthcare because organ injuries are common in Veterans, military personnel, and elderly. These studies may eventually save human lives, improve the health and wellbeing of Veterans, and decrease the number of disabilities among Veterans and in the general American population.

PI_NAMEs: BASNAKIAN, ALEXEI G (contact)

PROJECT_TERMS: Acetaminophen;Acute;Acute Kidney Failure;Acute myocardial infarction;Acute Renal Failure with Renal Papillary Necrosis;Affect;Alcohols;American;Antineoplastic Agents;Apoptotic;Area;Atherosclerosis;Award;Biology;Blood Vessels;Breast;Camptothecin;cancer cell;Carbon Nanotubes;Cardiovascular Diseases;cardiovascular risk factor;career;Cell Death;Cell Death Induction;Cell Differentiation process;cell injury;cell killing;Cell Membrane Permeability;Cells;Cessation of life;Chemical Injury;Chronic Kidney Failure;Cisplatin;Communication;Cytoprotective Agent;cytotoxic;Data;Deoxyribonuclease I;Deoxyribonucleases;disability;Disease;DNA;DNA Fragmentation;docetaxel;Drug or Chemical;Drug Side Effects;Elderly;endonuclease;Endothelial Cells;Enzymes;Epithelium;Etoposide;European;follow-up;Funding;gamma irradiation;General Population;Genomic DNA;Glycerol;Grant;Grant Review;Health;Healthcare;Heart;Hemodialysis;Hepatology;Homeostasis;Hospitalization;Human;human disease;Human Resources;Hypoxia;improved;Individual;inhibitor;Injury;International;Ions;Journals;Kidney;Kidney Failure;Low-Density Lipoproteins;Malignant Neoplasms;Measures;Mechanics;Mediating;Melanoma;military operation;Military Personnel;Modeling;Molecular Genetics;mortality;Muscle;Names;Nature;Nephrology;Nuclear Envelope;operation;Organ;Organ failure;organ injury;Patients;Personal Satisfaction;Pharmaceutical Preparations;pharmacologic;Physiology;Poisoning;Population;Prostate;Protective Agents;Proteins;Publishing;Radiation;Reporting;Research;Research Personnel;Risk;Risk Factors;Role;Scientist;Societies;sound;Thrombosis;tissue injury;Toxic effect;Toxic Hepatitis;Trauma;Tubular formation;United States Department of Agriculture;United States National Institutes of Health;Veterans

PROJECT_TITLE: BLRD Research Career Scientist Award Application


ORG_CITY: CHICAGO

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

ORG_STATE: IL

PHR: The apical sodium dependent bile acid transporter (ASBT) mediates bile acid absorption in the small intestine and controls their amount returning to the liver, which is a key regulator of cholesterol balance in the body. Blocking bile acid absorption reduces bile acid load and resortes cholesterol imbalance in the body. We recently discovered that ASBT activity can be regulated by a novel phenomenon called s-acylation, involving the attachment of different fatty acids to ASBT. The proposed studies are focused at investigating mechanisms that could effectively decrease bile acid absorption and also impact fatty acid and cholesterol metabolism to aid in the development of superior treatment for hypercholesterolemia. Diseases associated with hypercholesterolemia such as diabetes mellitus are highly prevalent among the veterans. The proposed studies are, therefore, relevant to the VA patients and the general patient population.

PI_NAMEs: ALREFAI, WADDAH A. (contact)

PROJECT_TERMS: absorption;Acids;Acylation;Acyltransferase;Address;ASBT protein;Bile Acids;Binding Proteins;Biochemical;Biological Models;Bioluminescence;Cardiovascular Diseases;cardiovascular risk factor;Carrier Proteins;Cell membrane;Cells;Chemistry;Cholesterol;cholesterol absorption;Cholesterol Homeostasis;Cholestyramine;Cysteine;Data;deacylation;Deterioration;Development;Diabetes Mellitus;Diet;dietary;Dietary Fatty Acid;Disease;Effectiveness;Eicosapentaenoic Acid;Enterohepatic Circulation;Enzymes;Equilibrium;ezetimibe;Fatty acid glycerol esters;Fatty Acids;feeding;Fish Oils;General Population;Health;High Fat Diet;high risk;high risk population;Homeostasis;Hospitalization;Human;hypercholesterolemia;Hyperlipidemia;in vitro Model;Individual;inhibitor;Intestines;Knockout Mice;Label;Lead;Light;Link;lipid metabolism;Lipids;Liver;Liver Fibrosis;liver inflammation;liver injury;long chain fatty acid;Mediating;Membrane;Membrane Lipids;Membrane Microdomains;Membrane Proteins;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;Methods;Modality;Modeling;Molecular;mouse model;Mus;novel;Oleates;Omega-3 Fatty Acids;Palmitates;Pathway interactions;patient population;Patients;Plant Resins;Plasma;Play;Post-Translational Protein Processing;posttranscriptional;Prevalence;Prevention;Recommendation;Reducing diet;Regulation;response;Response Elements;Role;Saturated Fatty Acids;Small Intestines;Sterols;Testing;Therapeutic;thioester;Time;Transgenic Mice;Transgenic Organisms;Unsaturated Fatty Acids;Veterans;Wild Type Mouse

PROJECT_TITLE: Regulation of Intestinal Bile Acid Absorption in Health and Cholesterol-Related Disorders


PHR: The potential benefits of this study are improvements in the diagnosis of precancerous polyps during colonoscopy, and enhancements in the quantification of colonoscopy quality measures. The study will focus on validating the use artificial intelligence to teach computers how to use endoscopic images to automatically classify polyps and other landmarks in the colon seen through the endoscope. One feature of our approach is that we use augmented reality to present the results from artificial intelligence predictions to endoscopists. This gives endoscopists immediate intuitive visual feedback about the polyp’s classification. Additional potential benefits of this research relating to healthcare include the following: 1. Real-time diagnosis of polyps would reduce the number of biopsies of benign tissue, significantly reducing procedure risks, costs and healthcare burden. 2. More thorough surveillance examinations could be performed to minimize missed precancerous polyps, thus decreasing cancer risk.

PI_NAMEs: RODRIGUEZ-DIAZ, ELADIO  (contact)

PROJECT_TERMS: Adoption;Age;American;Artificial Intelligence;Artificial Intelligence enhanced;artificial intelligence model;Aspirin;Augmented Reality;Benign;Biological Markers;Biopsy;Body mass index;Cancer Etiology;cancer risk;Cessation of life;Classification;Clinical;Clinical Data;clinical practice;clinical risk;clinically relevant;Colon;colon cancer prevention;Colonic Neoplasms;Colonoscopy;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;Colorectal Neoplasms;Colorectal Polyp;Computer Assisted;Computer-Assisted Diagnosis;Computers;cost;cost effectiveness;Cost Savings;Data;Data Set;Databases;deep field survey;deep learning;deep learning model;design;Detection;Development;Diagnosis;Disease Outcome;Diverticulum;Documentation;Educational process of instructing;Electronic Health Record;Endoscopes;Endoscopy;Excision;experience;Explosion;Family history of;Friends;Gastrointestinal Endoscopy;Gender;Generations;Goals;Guidelines;Healthcare;healthcare burden;Image;Image Analysis;improved;Individual;innovation;Interobserver Variability;Intervention;Intestines;Intuition;Label;Laboratory Study;Light;Measures;Methods;model design;Modeling;Morbidity - disease rate;mortality;Mucous Membrane;Neoplastic Polyp;network architecture;Optics;Output;Pathology;patient screening;Patients;Performance;Polypectomy;polyposis;Polyps;Precancerous Polyp;predictive modeling;Preparation;preservation;Procedures;quantitative imaging;Records;Rectum;Reporting;Research;Resected;Rest;Risk;Risk Factors;Screening for cancer;Semantics;Serrated Adenoma;skills;Societies;Tattooing;Technology;Testing;Time;Tissues;United States;visual feedback;Visualization

PROJECT_TITLE: Development of Artificial Intelligence-Based Approaches for Computer-Aided Management of Colorectal Polyps


PHR: The current study will identify differences in the oral microbiome of MS patients compared to controls, and between African American and White patients which will help in the diagnosis, prognosis, monitoring, and treatment of MS.

PI_NAMEs: FEINSTEIN, DOUGLAS L. (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;African American;Age;Anti-Inflammatory Agents;Bacteria;Butyrates;Butyrivibrio;caucasian American;Clinical;cohort;comparison control;Computer software;Data;design;Diagnosis;Disease;Disease Progression;Disease remission;DNA;Ethnic Origin;Etiology;Fatty Acids;France;Gender;Genetic;genetic variant;gut microbiome;gut microbiota;Home;Human Genetics;infection risk;Knowledge;Measures;metabolomics;Methods;microbial;microbiome;microbiome analysis;microbiome composition;microbiota;military veteran;Monitor;Monozygotic twins;multiple sclerosis patient;multiple sclerosis treatment;Nervous System Disorder;Neurodegenerative Disorders;Oral;Oral cavity;Oral Characters;oral microbiome;Patients;Population;Prognosis;Race;racial diversity;rapid technique;Relapse;Reporting;Risk Reduction;Saliva;saliva sample;Salivary;Sampling;Severity of illness;Source;species difference;Specificity;stool sample;Stress;Syndrome;Taxonomy;Testing;Therapeutic;Tissues;Treatment Efficacy;Twin Multiple Birth;Veterans

PROJECT_TITLE: Characterization of the oral microbiome of patients with Multiple Sclerosis


ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: Spinal cord injury (SCI) is a devastating event that affects younger Veterans and is associated with long-term disability including debilitating neuropathic pain. In the acute phase of SCI, secondary tissue injury and the initiation of chronic pain occur due to a robust neuroinflammatory response triggered by immune cells in the spinal cord. Because of the poor regenerative capacity of the spinal cord, interventions need to target this inflammatory response to maximize functional outcomes. Treatment must be immediate and at the time of injury. This proposal will investigate an inhibitor of HuR, a major protein that drives the neuroinflammatory response after SCI. This molecule can be given peripherally and it quickly suppresses induction of the inflammatory response. We will determine its ability to improve functional outcomes by blocking secondary tissue injury and chronic neuropathic pain after SCI. This research proposal is therefore directly relevant to Veteran health and has the potential to improve quality of life for those who have suffered SCI.

PI_NAMEs: KING, PETER H (contact)

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Acute;Adenine;Affect;Alzheimer's Disease;Astrocytes;Attenuated;attenuation;Binding;Biological Assay;Blood Vessels;CCL2 gene;Cells;Central Nervous System;central nervous system injury;chemokine;Chest;chronic neurologic disease;chronic neuropathic pain;chronic pain;Cicatrix;Clinical;Contusions;CXCL1 gene;cytokine;Cytoplasm;cytotoxic;cytotoxicity;Data;Development;Dyes;Early Intervention;Edema;Elements;Event;Extravasation;Financial Hardship;Flow Cytometry;functional improvement;functional outcomes;Gelatinase A;Gene Expression Regulation;glial activation;Health;HuR protein;Immune;Immunohistochemistry;improved;improved outcome;Infiltration;Inflammation Mediators;Inflammatory;inflammatory milieu;Inflammatory Response;inhibitor;inhibitor therapy;injured;Injury;injury recovery;innovation;insight;Interleukin-1 beta;Interleukin-6;Intervention;Invaded;Investigation;Ischemia;Knock-out;life span;Link;Long term disability;Measurement;Measures;Mediating;Mediator;Messenger RNA;Microglia;migration;Modeling;monocyte;Morbidity - disease rate;Motor;motor recovery;mRNA Stability;Mus;nerve injury;Neuroglia;neuroinflammation;neuron loss;Neurons;neuroprotection;neutrophil;new therapeutic target;Nitrogen;Nociception;novel;Oligodendroglia;Outcome;overexpression;Oxygen;Pain;Pain Measurement;painful neuropathy;Pathway interactions;Patients;Penetration;Peripheral;Peripheral nerve injury;Persons;Phase;Pilot Projects;Post-Transcriptional Regulation;posttranscriptional;preclinical study;Production;protein expression;Proteins;prototype;Quality of life;Recovery;recruit;Regenerative capacity;Research Proposals;response;RNA;RNA-Binding Proteins;Rodent Model;Secondary Prevention;Secondary to;severe injury;small molecule;small molecule inhibitor;Spinal Cord;Spinal cord injury;Stroke;Testing;Therapeutic;therapeutic target;Time;tissue injury;Tissues;TNF gene;Toxic effect;transgene expression;Translations;Traumatic Brain Injury;Uridine;Vascular Permeabilities;vasogenic edema;Veterans;Walking;Water;white matter;Work

PROJECT_TITLE: Therapeutic benefit of targeting neuroinflammation in spinal cord injury with a novel small molecule inhibitor of the RNA regulator HuR


ORG_CITY: COLUMBIA

ORG_NAME: HARRY S. TRUMAN MEMORIAL VA HOSPITAL

ORG_STATE: MO

PHR: Project Narrative  Cardiovascular diseases (CVD) are the major causes of morbidity and mortality in veterans. For two decades, my research focused on dissecting the molecular mechanisms underlying the initiation and progression of inflammatory CVD, has identified four potential therapeutic targets: IL-18 (Interleukin-18), TRAF3IP2 (TRAF3 Interacting Protein 2), Larp6 (La Ribonucleoprotein Domain Family Member 6), and RECK (Reversion Inducing Cysteine Rich Protein with Kazal Motifs. Increased expression of IL-18 and TRAF3IP2 play a causal role in myocardial injury, adverse cardiac remodeling, and HF development. Larp6, a RNA-bing protein, plays a role in collagen synthesis. RECK inhibits multiple mediators involved in adverse cardiac remodeling. My goal of determining if neutralizing IL-18, inhibiting TRAF3IP2 or Larp6, or inducing RECK can blunt progression of CVD is highly relevant to veterans and the mission of the Veterans Health Care System.

PI_NAMEs: BYSANI, CHANDRASEKAR  (contact)

PROJECT_TERMS: Affect;Aldosterone;Angiotensin II;antagonist;Antiinflammatory Effect;aortic valve replacement;Atherosclerosis;Award;Binding;Biopsy;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;career;Cell Death;cell type;Characteristics;chemokine;Chronic Disease;Collaborations;Collagen;Colorado;comorbidity;Complement Factor H;coronary fibrosis;Critical Pathways;cysteine rich protein;cytokine;Cytoplasm;Data;Deposition;Development;Diabetes Mellitus;Disclosure;Disease Progression;Docking;efficacy testing;Eligibility Determination;Endothelial Cells;Etiology;Family member;Fibrillar Collagen;Fibroblasts;Florida;Functional disorder;functional improvement;Funding;gain of function;Gene Deletion;Genes;Genetic;Goals;GPI Membrane Anchors;Healthcare;Healthcare Systems;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;Human;Hypertension;Hypertrophy;IL17 gene;IL18 gene;IL6ST gene;improved;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Injury;Interleukin-1;Interleukin-6;Interleukins;Intervention;Intervention Studies;invention;Ischemia;ischemic injury;Isoproterenol;Knock-in Mouse;Knock-out;loss of function;MAP Kinase Gene;MAPK8 gene;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mediating;Mediator;Membrane;Messenger RNA;Microbubbles;migration;military veteran;Mission;Modeling;Molecular;molecular modeling;Morbidity - disease rate;mortality;mouse model;Mutate;Myocardial;Myocardial dysfunction;myocardial injury;Myocardial Ischemia;neutralizing antibody;new therapeutic target;NF-kappa B;Nodal;Obesity;overexpression;Oxidative Stress;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathologic;Patient-Focused Outcomes;Patients;Persons;pharmacologic;Phase;Pilot Projects;Play;Population;posttranscriptional;Pre-Clinical Model;pressure;Problem Solving;Progressive Disease;Proliferating;promoter;Proteins;Publications;Recombinant Interleukins;Reperfusion Therapy;Reporting;Research;Research Personnel;Ribonucleoproteins;RNA;RNA-Binding Proteins;Role;Scientist;Services;sex;Signal Transduction;Signal Transduction Pathway;small molecule;small molecule inhibitor;Smoking;stem;Survivors;Testing;Therapeutic;therapeutic target;tissue injury;Tissues;TLR4 gene;TNF receptor-associated factor 3;transcription factor;Transcription Factor AP-1;Transgenic Mice;Troponin;ubiquitin ligase;ultrasound;United States National Center for Health Statistics;Universities;Ventricular Remodeling;Veterans;Work


PHR: Many stroke survivors will develop impairments in memory, thinking, or decision-making due to the damage in the blood vessels in the brain, which is called vascular contributions to cognitive impairment and dementia (VCID); hence, there is a need to develop therapies that will improve or prevent these impairments following stroke. Insulin resistance, a common comorbidity in stroke survivors, reduces brain insulin levels, which can impact several processes important for the recovery of vessel damage due to stroke. The current proposal will investigate the benefit of improving brain insulin levels and signaling in preventing damage to blood vessels and in alleviating memory, thinking, or decision-making impairments.

PI_NAMEs: ROBINSON, CATRINA SIMS (contact)

PROJECT_TERMS: Adherence;Animal Experimentation;Animal Model;Blood capillaries;Blood Cells;Blood flow;Blood Vessels;blood-brain barrier function;Brain;brain cell;brain endothelial cell;Bypass;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrovascular system;Clinical Trials;Cognition;Cognition Disorders;Cognitive;Cognitive deficits;cognitive function;combat;comorbidity;Core-Binding Factor;Data;Decision Making;Development;Diabetes Mellitus;Diet;Endocytosis;Endothelial Cells;Endothelium;Functional disorder;Goals;Guidelines;High Fat Diet;Hippocampus;Hyperinsulinism;Impaired cognition;Impairment;improved;Industry;innovation;Insulin;Insulin Receptor;Insulin Resistance;insulin signaling;interest;Ischemia;Ischemic Stroke;Laboratories;Measures;Mediating;Memory;Methods;middle age;Middle Cerebral Artery Occlusion;Modeling;Molecular;Motor;mouse model;multiphoton imaging;Mus;Nervous System Physiology;Neurologic;Neuronal Plasticity;Neurons;new therapeutic target;Outcome;Patients;post stroke;prevent;Process;Protein Dephosphorylation;protein tyrosine phosphatase 1B;Receptor Signaling;Recommendation;Recovery;Recovery of Function;Research;Research Design;Risk Factors;Role;Saline;Sensorimotor functions;Signal Transduction;Stroke;stroke model;stroke survivor;stroke therapy;Structure;Survival Rate;targeted treatment;Techniques;Testing;Thalamic structure;Therapeutic;therapeutic target;therapy development;Thinking;Transgenic Mice;Tyrosine;Tyrosine Phosphorylation;vascular cognitive impairment and dementia;Vascular Diseases;Vascular Endothelial Cell;vascular risk factor;Vibrissae

PROJECT_TITLE: Targeting brain insulin to improve stroke-related vascular contributions to cognitive impairment and dementia


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Dr. Risbrough’s research program on post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI) is highly relevant to Veterans’ health in a number of ways. First, her aims to identify the molecular and genetic mechanisms of risk and symptom maintenance for post-traumatic stress disorder (PTSD) supports development of novel targets for interventions across the trauma-response trajectory, i.e. both early and late periods post-trauma. Second, her studies to develop fluid biomarkers of mild TBI and its associated cognitive disruption may provide a clinically feasible tool to aid diagnosis as well as prediction of long-dysfunction. Third, her work in understanding mechanisms of the gold-standard treatment for PTSD, exposure therapy, and how it can be enhanced through additional behavioral and pharmacological therapies is aimed at improving treatment outcome in Veterans with PTSD.

PI_NAMEs: RISBROUGH, VICTORIA B (contact)

PROJECT_TERMS: Acute;Adult;alcohol comorbidity;Alcohol consumption;Animal Model;Astrocytes;Award;Behavior;Behavioral;biobank;biological adaptation to stress;Biological Markers;Biological Psychiatry;blood-based biomarker;California;career;cell type;Chronic;Clinical;Clinical Research;Clinical Trials;Cognitive;Collection;combat;Communication;Corticotropin-Releasing Hormone;Country;CRF receptor type 1;CRF receptor type 2;cytotoxicity;Department of Defense;Development;Diagnosis;Diagnostic;Disease;dopamine system;endogenous cannabinoid system;exosome;Extinction;follow-up;Fright;frontier;Functional disorder;Functional impairment;Funding;Future;Genetic;Genetic Polymorphism;Genetic Risk;genetic risk factor;Health;health science research;Healthcare Systems;heart rate variability;Hormones;Human;Immune system;improved;indexing;Intervention;Journals;K-Series Research Career Programs;Laboratories;Laboratory Research;Learning;life span;Liquid substance;longitudinal, prospective study;Maintenance;Manuscripts;marine;Marines;Mental Health;Mentors;Mentorship;mild traumatic brain injury;Molecular;Mus;National Institute of Mental Health;National Institute on Alcohol Abuse and Alcoholism;Nature;Nerve Degeneration;Neurobiology;Neurons;neuropathology;neuropsychopharmacology;Neurosciences;Neurosciences Research;novel;Oxytocin;pharmacologic;Pharmacological Treatment;Physiological;post-trauma;Post-Traumatic Stress Disorders;pre-clinical;pre-clinical research;Principal Investigator;professor;prognostic tool;programs;Proteins;Psychiatry;Psychopharmacology;Psychophysiology;psychosocial;Publications;Publishing;receptor function;Receptor Gene;Recovery;Research;Research Personnel;resilience;response;Risk;Risk Marker;Role;Running;Scientist;Signal Transduction;Sleep;Specialist;specific biomarkers;standard care;Stress;success;Symptoms;System;therapy development;tool;Training;translational research program;Trauma;Traumatic Brain Injury;Treatment outcome;United States National Institutes of Health;Universities;Veterans;Work


PHR: There is strong evidence that inflammation plays an important role in the progression of disease in amyotrophic lateral sclerosis, and the case rate for this disease is higher among deployed Veterans. Studies proposed investigate inflammatory pathways involved in deteriorating motor functions, and additionally investigates a novel therapeutic approach that targets these inflammatory pathways.

PI_NAMEs: TOMLINSON, STEPHEN  (contact)

PROJECT_TERMS: activation product;Address;Aftercare;ALS pathology;ALS patients;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;analog;Animal Model;Animals;Area;Binding;Biological Availability;C3bi;Central Nervous System;Chimeric Proteins;Clinical Research;Clinical Trials;Complement;Complement 1q;Complement 3d;Complement 3d Receptors;Complement Activation;complement C3d,g;Complement Inactivators;complement pathway;complement system;Data;Data Set;Deposition;Deterioration;Development;Disease;Disease Progression;effective therapy;Female;Foundations;Functional disorder;Genetic Complementation Test;Goals;Guidelines;Gulf War veteran;Human;Immune;Individual;Infection;Inflammation;Inflammatory;inhibitor;Injury;interest;Investigation;Ligands;link protein;male;Methodology;Military Personnel;Modeling;Monoclonal Antibodies;Motor;Motor Endplate;Motor Neurons;mouse model;Mus;Neuroglia;neuroinflammation;novel;novel strategies;novel therapeutic intervention;pathogen;Pathologic;Pathway interactions;Peripheral;Physiological;Pilot Projects;Play;preclinical study;Predisposition;PrP;response;Risk;Role;Route;Safety;Site;Testing;Therapeutic;Time;time use;Tissues;tool;Veterans;Work

PROJECT_TITLE: The complement system in ALS


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Sepsis strikes 750,000 Americans every year; prolonged hospitalization, secondary infections, sepsis recidivism, and hospital readmission are the most common long-term consequences in sepsis survivors. The long-term goal of Dr. Thomas Griffith’s laboratory is to define the cellular and molecular mechanisms responsible for the chronic state of sepsis-induced immunoparalysis by performing cutting-edge, biomedical research using a combination of preclinical models and clinical samples. It is by building upon such detailed understanding of sepsis pathophysiology that new, promising clinical treatments can be developed, and existing treatments improved. It is in this way that this PhD basic scientist aims to contribute to the health needs of our nation’s Veterans.

PI_NAMEs: GRIFFITH, THOMAS S (contact)

PROJECT_TERMS: Acute;Address;Adult;Age;aging population;American;Award;B-Lymphocytes;Biology;Biomedical Research;Birth;career;Cause of Death;CD4 Positive T Lymphocytes;Cell Compartmentation;Cells;Cellular Immunity;Cessation of life;Chronic;Classification;Clinical;Clinical Research;clinical translation;Clinical Treatment;clinically relevant;clinically significant;Collaborations;commensal microbes;comorbidity;Critical Illness;cytokine;cytokine release syndrome;Data;Death Rate;Development;Diagnosis;Dissection;Doctor of Philosophy;emerging pathogen;Event;expectation;experience;Exposure to;fitness;Functional disorder;Funding;germ free condition;Goals;Grant;Growth;gut microbiota;Health;Health Expenditures;health science research;Healthcare;Healthcare Systems;Heterogeneity;Hospital Mortality;hospital readmission;Hospitalization;Hospitals;Housing;Human;Human Biology;Immune;Immune response;Immune system;Immune System Diseases;Immunologic Adjuvants;Immunosuppression;Impairment;improved;Incidence;indexing;Infection;Innate Immune Response;Inpatients;insight;Institution;Intervention;Investigation;Iowa;Knowledge;Laboratories;Laboratory mice;memory CD4 T lymphocyte;microbial;Minnesota;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;neonate;novel;Outcome;Paper;pathogen;pathogen exposure;pathogenic microbe;Patients;Persons;Physiological;Population;Positioning Attribute;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical efficacy;preclinical study;Productivity;professor;Public Health;Publications;Publishing;readmission rates;recidivism;recurrent infection;Reporting;Reproducibility;Research;Research Activity;Research Personnel;Resources;response;Sampling;Scientist;secondary infection;Sepsis;septic;septic patients;Shapes;Specialist;success;Survivors;T-Lymphocyte;Testing;Training;Treatment Efficacy;United States National Institutes of Health;Universities;Urology;Vaccination;Veterans;Vulnerable Populations;Work


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: This proposal addresses a critical need for both our older and younger populations of veterans. Head trauma may be a risk factor for both amyotrophic lateral sclerosis and Chronic Traumatic Encephalopathy, a neurodegenerative disease caused by repetitive mild traumatic brain injury. Soldiers have always been at risk for head injury and this is particularly the case for OEF/OIF veterans, many of who have experienced explosive blast injury and participated in contact sports. There is a critical need to understand the mechanisms and genetic risk factors underlying this injury to facilitate prevention, diagnosis, and treatment. The aging veteran population and high rate of head injury will lead to daunting costs and responsibilities for the VA if research aimed at translating mechanisms into biomarkers and treatments is not developed.

PI_NAMEs: STEIN, THOR  (contact)

PROJECT_TERMS: Address;Aging;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Area;Atrophic;Autopsy;Axon;Behavior;Behavioral;Behavioral Symptoms;Biological Markers;Blast Injuries;CCL2 gene;CDC42 gene;chronic traumatic encephalopathy;Clinical;Cognitive;cohort;Collection;comorbidity;contact sports;cost;Craniocerebral Trauma;cytokine;Data;Development;Diagnosis;Disease;disease phenotype;Disease Progression;DNA;drug discovery;Drug Targeting;experience;Frequencies;Frontotemporal Lobar Degenerations;Gene Expression;gene network;Genes;Genetic;Genetic Risk;genetic risk factor;genome-wide;genomic variation;Genotype;glial activation;Gliosis;Goals;gray matter;head impact;human subject;Impaired cognition;Individual;Inflammatory;inflammatory modulation;Injury;Interferon Type II;Interleukin-1;Interleukin-4;Interleukin-6;Link;Logistic Regressions;Meta-Analysis;Methodology;Methods;Microglia;mild traumatic brain injury;military veteran;Molecular;Moods;Myelin;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuroinflammation;neuron loss;neuropathology;novel;Outcome;Participant;Pathologic;Pathology;Pathway interactions;Pattern;PGRN gene;Phenotype;Play;Population;predict clinical outcome;Prefrontal Cortex;preservation;Prevalence;Prevention;progressive neurodegeneration;protein TDP-43;Proteins;Recording of previous events;Research;Research Project Grants;Risk;Risk Factors;risk variant;RNA;Role;Severities;Soldier;Symptoms;Synapses;targeted treatment;tau Proteins;Testing;TNF gene;Transcript;transcriptome;transcriptome sequencing;Translating;translational approach;Traumatic Brain Injury;Variant;Veterans;white matter

PROJECT_TITLE: Genetic and environmental modifiers of pathology in amyotrophic lateral sclerosis


ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Bladder dysfunction is highly prevalent in the aging veteran population and is the most common complication of diabetes and Parkinson’s disease. Disorders of the bladder are often ignored or overlooked in those with comorbidity, which can lead to a devastating series of pathological events. The negative impact of bladder dysfunction on the physical, mental, emotional and social health of the veteran population, as well as on the financial and healthcare delivery responsibilities of the VHA, underlie the critical need to better understand and manage problems related to the bladder. This proposal will investigate a novel signaling complex underlying bladder neurotransmission that is disrupted by diabetes and Parkinson’s disease. New insights regarding this shared bladder neuropathology will establish a foundation for design of better targeted pharmacotherapy and provide opportunities for early intervention of progressive neurogenic bladder dysfunction.

PI_NAMEs: SULLIVAN, MARYROSE P (contact)

PROJECT_TERMS: Acceleration;Actins;Address;adverse outcome;Age;Aging;Agonist;alpha synuclein;Amyloid;Animal Disease Models;Animal Model;Anti-diabetic Drugs;Biochemical;Biological Process;Bladder;Bladder Diseases;Bladder Dysfunction;blood glucose regulation;Brain;Cerebrospinal Fluid;Chronic Disease;Cohort Studies;comorbidity;Complex;Complications of Diabetes Mellitus;Cytoskeleton;Data;Defect;Deposition;design;Diabetes Mellitus;diabetic;Disease;Disease Progression;Distress;Docking;Early identification;Early Intervention;effective intervention;Emotional;Epidemiology;Event;Exocytosis;Family;Foundations;Functional disorder;functional restoration;General Population;genome wide association study;GLP-I receptor;glucagon-like peptide;glucagon-like peptide 1;glucose metabolism;glycation;Health;health care delivery;high risk;Hyperglycemia;Impaired cognition;Impairment;improved;In Vitro;insight;loss of function;Lower urinary tract;Mediating;Methods;military veteran;Molecular;Molecular Conformation;mortality risk;Motor;motor function improvement;motor impairment;multidisciplinary;Myosin ATPase;Nerve;Nerve Degeneration;Nerve Fibers;nerve supply;Neurodegenerative Disorders;Neurogenic Bladder;neuropathology;neuroprotection;neurotoxicity;neurotransmission;Non-Insulin-Dependent Diabetes Mellitus;novel;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phosphorylation;Physiological;presynaptic;presynaptic neurons;Prevalence;Primates;Process;Property;Proteins;Psyche structure;psychologic;Quality of life;response;restoration;Risk;Role;Series;Severities;Signal Transduction;social;Symptoms;Synaptic Vesicles;Techniques;Testing;Therapeutic;trafficking;treatment strategy;Varicosity;Veterans

PROJECT_TITLE: Bladder Dysfunction and Dysregulation of Neurotransmission


ORG_CITY: EAST ORANGE

ORG_NAME: VA NEW JERSEY HEALTH CARE SYSTEM

ORG_STATE: NJ

PHR: Neurodegeneration in the brain and spinal cord represent significant problems for Veterans. For example, traumatic brain injury (the signature affliction of approximately 320,000 of the deployed personnel in recent combat operations overseas) is currently untreatable and has persistent effects on patients, families, and our healthcare system. Another example involves the high number, in excess of 25%, of the Veterans of Operation Desert Storm suffering a multisymptom disorder termed Gulf War Illness frequently involving neurological problems. These and other neurodegenerative conditions affecting Veterans warrant a better understanding of the molecular causes to help in the development of treatments to improve their health and quality of life. By identifying key factors influencing the course of neurodegeneration and testing treatments to reduce and reverse the losses of neuronal function the goal to improve the outcome for Veterans will be advanced.

PI_NAMEs: CITRON, BRUCE A. (contact)

PROJECT_TERMS: Accidents;Affect;Aging;ALS patients;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Animal Model;Animals;Applications Grants;Area;Astrocytes;Attention;Award;behavior test;bench to bedside;Binding;Biochemical Pathway;Biological Models;Brain;career;CASP3 gene;Caspase;Cells;Central Nervous System;Cessation of life;Characteristics;Chronic;Clinical;Clinical Research;Clinical Trials;Cognitive;cognitive function;cognitive testing;combat;combat zone;Complex;Conflict (Psychology);cost;cytokine;Development;Disease;DNA-Binding Proteins;Down-Regulation;effective therapy;experience;experimental study;falls;Family;functional loss;Gene Expression;Gene Expression Profile;General Population;Genes;Goals;Gulf War;Health;Healthcare;Healthcare Systems;Human;Human Resources;improved;improved outcome;Incidence;Inflammatory;Injury;Intervention;Investigation;Ketones;Knowledge;Laboratories;Life;Measures;Memory;Microglia;Military Personnel;military veteran;Modeling;Molecular;Molecular Biology;Molecular Genetics;Motor Neuron Disease;Motor Neurons;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurologic;neuron loss;Neurons;neuroprotection;neuropsychiatry;Neurosciences;new therapeutic target;NF-kappa B;novel;operation;Paralysed;Pathway interactions;Patients;Peptide Hydrolases;Performance;Persian Gulf;Persian Gulf Syndrome;Pharmacologic Substance;Predisposition;Prevalence;Prevention;Problem behavior;Process;Proteins;Publishing;Quality of life;Regulation;Regulatory Pathway;Research;Rest;Risk;Sampling;Scientist;Services;Signal Transduction;Societies;Spinal Cord;Spinal cord injury;Sports;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;therapy development;tissue culture;transcription factor;Transcriptional Regulation;Transgenic Mice;transgenic model of alzheimer disease;Translating;Traumatic Brain Injury;Traumatic CNS injury;Traumatic injury;treatment optimization;treatment strategy;Up-Regulation;Veterans


ORG_CITY: LONG BEACH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Water-soluble vitamins are essential micronutrients for normal human health and well-being. Their deficiencies (whether systemic or tissue-specific) lead to a variety of serious clinical abnormalities. The incidences of deficiency/sub-optimal levels of water-soluble vitamins are common in our Veterans as well as in the general population, and occur due to a variety of factors/conditions and diseases. This include chronic alcohol consumption, chronic exposure to cigarette smoke, inflammation (as in inflammatory bowel diseases), infection with foodborne enteric-pathogens, diabetes mellitus, drug-nutrient interactions, and aging. Our studies aim at understand the cellular/molecular mechanisms involved in the absorption/transport of water-soluble vitamins in organs of the digestive system, and how external/internal factors and disease conditions negatively impact these processes. Our ultimate goal is to identify effective strategies to prevent vitamin malabsorption and deficiencies, and thus, improve human health and well-being.

PI_NAMEs: SAID, HAMID M (contact)

PROJECT_TERMS: absorption;Address;Affect;Aging;alcohol exposure;Anemia;Animal Model;Animals;Area;ascorbate;Award;Bacterial Toxins;Biological;Biotin;Book Chapters;Books;Cardiovascular system;career;Carrier Proteins;Celiac Disease;Cell Line;Cell Separation;Cells;Cellular biology;Chronic;chronic alcohol ingestion;Chronic Disease;Clinical;Collaborations;Colon;confocal imaging;Cultured Cells;cytokine;Dermatologic;Development;Diabetes Mellitus;Diphosphates;Disease;DNA Sequence Alteration;Doctor of Philosophy;Educational process of instructing;enteric pathogen;Environmental Risk Factor;Epigenetic Process;Epithelium;Event;Excision;Exposure to;exposure to cigarette smoke;Folic Acid;Food-Drug Interactions;foodborne;Functional disorder;Funding;gastrointestinal system;General Population;Generations;Genetic;Genetic Transcription;Goals;Growth;Health;Height;Homeostasis;Human;Hypoxia;imaging approach;Imaging Techniques;Impairment;improved;Incidence;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Intake;interest;Intestinal Diseases;Intestines;Investigation;knockout animal;Large Intestine;Lead;Malabsorption Syndromes;Mediating;Medical Genetics;Membrane;Mentors;microbiota;Micronutrients;Molecular;Molecular Biology;molecular imaging;Mutation;Neurologic;next generation;Nicotinic Acids;Oral;Organ;Organelles;Pancreas;Pantothenic Acid;Peer Review;Personal Satisfaction;Pharmaceutical Preparations;Physiological;Physiology;Post-Translational Regulation;posttranscriptional;prevent;Process;programs;Publishing;Research;Research Personnel;Riboflavin;Scientist;Seminal;Small Intestines;Structure;success;System;Thiamine;Tissues;trafficking;Training;Transport Process;United States National Institutes of Health;Universities;uptake;Veterans;Vitamin B6;Vitamins;Water;Water-Soluble Vitamin;Work


ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

PHR: Multiple sclerosis (MS) occurs when the immune system mistakenly attacks myelin in the brain, leading to loss of motor function. MS affects a large number of Veterans and no cure exists. Further, existing treatments are not specific and can leave patients immunocompromised. The need for life-long treatment also creates a large burden on patients and families. The goal of this project is to use nanotechnology to control signal processing in lymph nodes, tissues that regulate immune function. This ability could promote regulatory immune cells that specifically control the inflammatory cells attacking myelin. This advance would benefit Veteran’s health in three ways. First, myelin-specific tolerance that controls disease without hindering healthy immunity would improve efficacy and Veteran quality of life. Second, generating long-lasting regulatory cells would enable less frequent treatments, improving patient compliance and reducing the burden of managing disease. Lastly, since treatments might provide permanent improvements, healthcare costs for Veterans and families could be greatly reduced.

PI_NAMEs: JEWELL, CHRISTOPHER M (contact)

PROJECT_TERMS: Address;Adjuvant;Affect;Animal Model;Antibodies;Antigens;Autoantigens;Autoimmune Diseases;Autoimmunity;Award;Biocompatible Materials;Biomedical Engineering;Brain;capsule;Caring;Cells;Central Nervous System;Characteristics;Clinical;clinical development;Clinical Research;Collaborations;cost;Cues;cytokine;Data;density;Disease;Disease Management;disease model;Disease remission;disorder control;draining lymph node;effective therapy;Electrostatics;Encapsulated;Engineering;Epitopes;Equilibrium;Exhibits;Experimental Autoimmune Encephalomyelitis;Family;Female;Future;Goals;Health;Health Care Costs;Humira;Immune;immune function;Immune response;Immune signaling;Immune system;Immunity;Immunocompromised Host;immunoengineering;Immunologics;Immunologist;Immunology;Immunosuppressive Agents;Immunotherapy;improved;Incidence;Inflammation;Inflammatory;Injections;interest;Interleukin-10;Investigational Therapies;Ligands;Link;Lipids;lymph nodes;Lymphatic;male;Mediating;Modeling;Molecular Target;Monoclonal Antibodies;Motor;multidisciplinary;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Mus;Myelin;nanoparticle;Nanostructures;Nanotechnology;Natural Immunity;Nature;Nervous System Physiology;Neurodegenerative Disorders;new technology;novel;novel therapeutics;Nucleic Acids;Paralysed;particle;Pathogen detection;Pathogenicity;Pathology;Pathway interactions;Patient Compliance;Patients;Pattern;Peptides;Persons;Pilot Projects;polarized cell;Polymers;Population;pre-clinical;Pre-Clinical Model;preclinical study;preservation;Process;programs;Quality of life;receptor function;Receptor Signaling;Recording of previous events;Regulatory T-Lymphocyte;Relapse;response;restraint;Role;Route;Sampling;self assembly;signal processing;Signal Transduction;Sirolimus;Specificity;Spleen;Structure;T cell differentiation;T-Lymphocyte;targeted treatment;Technology;Testing;Time;Tissues;TNF gene;Toll-like receptors;Translations;vaccine evaluation;Vaccines;Veterans;Work

PROJECT_TITLE: Tunable Assembly of Regulatory Immune Signals to Promote Myelin-specific Tolerance


PHR: PROJECT NARRATIVE Currently no treatment is available to slow down or stop neurodegenerative processes of Alzheimer’s disease (AD). My research program has an ongoing interest of developing investigational new drugs (IND)-enabling novel therapies for AD. We have been studying a novel target to improve cognitive function, called synaptojanin 1 (synj1) and several lines of data suggest beneficial effects of synj1 reduction in AD. We have developed scaffolds of novel small molecules with synj1-lowering capabilities, and identified two lead compounds with great oral bioavailability, blood brain barrier (BBB) penetrability and long-term in vivo efficacy at improving cognitive function in multiple AD mouse models. Therefore, we propose to perform the IND-enabling studies of two lead compounds including pharmacological and toxicology studies, as well as biomarker development with the ultimate goals of transitioning into clinical studies and the commercialization of our novel AD therapies.

PI_NAMEs: CAI, DONGMING  (contact)

PROJECT_TERMS: Abeta clearance;Acceleration;Acute;Age of Onset;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease therapy;Amyloid;Amyloid beta-42;Amyloid beta-Protein;analog;Animal Model;apolipoprotein E-4;Attenuated;Behavior;Behavioral;Binding Proteins;Biological Availability;Biological Markers;biomarker development;Blood - brain barrier anatomy;Brain;Calcium Channel;Canis familiaris;Cells;Chemistry;Chronic;chronic traumatic encephalopathy;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;Cognitive deficits;cognitive function;cognitive performance;Collaborations;commercialization;Data;Defect;Dementia;Development;Diagnosis;Disease;Dose;Down's Syndrome;Down-Regulation;drug development;Drug Kinetics;drug metabolism;Early Endosome;efficacious treatment;efficacy study;Ensure;Enzymes;Evaluation;Exhibits;exosome;familial Alzheimer disease;Foundations;Functional disorder;Funding;Future;Genetic;Genetic Polymorphism;genotoxicity;Goals;Human;human disease;hyperphosphorylated tau;Impaired cognition;improved;In Vitro;in vivo;innovation;interest;Investigational Drugs;Investigational New Drug Application;knock-down;Knock-in Mouse;Lead;lead optimization;Legal patent;manufacture;Marketing;Medical;MicroRNAs;mild traumatic brain injury;Mission;Morbidity - disease rate;mortality;mouse model;Mus;Nerve Degeneration;Neurites;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;Nimodipine;novel;novel therapeutic intervention;novel therapeutics;Oral;Parents;Pathologic;Pathologic Processes;Pathology;Pathway interactions;Penetration;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phase I Clinical Trials;Phospholipids;Plasma;potential biomarker;pre-clinical;preclinical development;Preparation;prevent;Preventive;Process;programs;protein metabolite;Proteins;Rattus;Research;Role;Sampling;scaffold;screening;Sensitivity and Specificity;Serum;side effect;small molecule;success;Surrogate Markers;Synapses;SYNJ1 gene;System;tau Proteins;Therapeutic;Toxic effect;Toxicology;Traumatic Brain Injury;United States Department of Veterans Affairs;United States Food and Drug Administration;Veterans

PROJECT_TITLE: Novel Disease-modifying Small Molecules for Treatment of Alzheimer's Disease”


ORG_CITY: DETROIT

ORG_NAME: JOHN D DINGELL VA MEDICAL CENTER

PHR: The nominee’s research investigates molecular mechanisms of disorders associated with chronic inflammation such as breast and lung cancers, and reno-vascular hypertension. These diseases are known to cause significant morbidity and mortality with attendant increases in direct medical costs, loss of productivity and quality of life in our veterans of all ages. The research projects are intended to elucidate mechanisms of drug resistance in human triple-negative breast (TNBC) and non-small cell lung cancers (NSCLC), and exploit this knowledge to design, synthesize and optimize novel compounds that inhibit therapy-induced survival, and activate CARP-1 and apoptosis in naïve and drug-resistant cancer cells. CARP-1 and the novel CFM and SNI compounds were discovered by the nominee through the VA supported Merit funds. The nominee is also productively collaborating with Detroit VA clinician to investigate mechanisms of reno-vascular hypertension, and served as co-investigator on two, VA Merit proposals. Rishi - 1

PI_NAMEs: RISHI, ARUN KUMAR (contact)

PROJECT_TERMS: Adriamycin PFS;Age;American Cancer Society;Angiotensins;anti-cancer;anti-cancer research;anti-cancer therapeutic;Apoptosis;Apoptosis Regulation Gene;Area;Atherosclerosis;Attenuated;Award;Behavioral Mechanisms;behavioral response;Binding;Biological;biological adaptation to stress;Breast;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Treatment;Breast Epithelial Cells;cancer cell;Cancer Cell Growth;Cancer Etiology;Carcinogens;Cardiac Catheterization Procedures;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;career;cell growth;Cell model;Cell Survival;Cessation of life;Chemicals;Chemoresistance;chemotherapy;Chronic;Chronic Disease;Cisplatin;Clinic;Collaborations;combat;Coupled;Cyprinus carpio;Depressed mood;depression model;design;Development;Diagnosis;Disease;DNA Sequence Alteration;Drug resistance;effective therapy;Endothelin;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Etoposide;Exposure to;falls;Female;Formulation;Foundations;Funding;Gefitinib;General Population;genotoxicity;Goals;Growth;healing;Health;Healthcare;Healthcare Systems;Heart Diseases;High Prevalence;Hormones;Human;human old age (65+);Hypertension;improved;improved outcome;in vivo;Incidence;Individual;Induction of Apoptosis;Inflammation;inhibitor;Kidney;kidney vascular structure;knockout gene;Knowledge;Lipids;lung cancer cell;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Medical Care Costs;men;Mental Depression;Military Personnel;mimetics;Mission;Modality;Modeling;Molecular;Morbidity - disease rate;mortality;mortality risk;mutant;Mutation;Myocardial Infarction;nano;Neurons;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Occupational Exposure;Pathway interactions;Phosphotransferases;pre-clinical;preclinical study;Prevalence;prevent;Process;Productivity;productivity loss;programs;Proteins;Quality of life;refractory cancer;Regulation;Relapse;Renal Artery Stenosis;Renal Carcinoma;Renovascular Hypertension;Research;Research Activity;Research Personnel;Research Project Grants;Resistance;Rheumatoid Arthritis;Risk;Rodent Model;Scientist;Seminal;service member;Services;Signal Induction;Signal Transduction;small molecule;smoking prevalence;Socioeconomic Status;Stimulus;Stress;Stroke;success;targeted treatment;Therapeutic;Therapeutic Uses;therapy outcome;therapy resistant;Treatment Efficacy;Treatment Failure;triple-negative invasive breast carcinoma;Vasopressins;Veterans;Woman;Women's mortality