ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Suicide prevention is VA’s highest clinical priority, and the greatest number of lives lost to suicide are in older Veterans. To advance the science in suicide risk research, we need an Individualized Approach, especially for aging Veterans—informing how best to target the multidisciplinary needs of older Veterans, which in turn will inform how best to mitigate and prevent suicide. Research is lacking that addresses the complexities of comorbidities in older Veterans who attempt suicide, and little is known about social risk factors, although they are likely hugely impactful—and next to nothing is known about how these factors may characterize individuals at greatest risk. The proposed project will provide necessary and relevant knowledge on the near-term typologies and long-term trajectories that lead to suicide death for aging Veterans and the pathways from suicide attempt to mortality, this project will inform the development of person-centered suicide prevention and intervention strategies in the segment of the population with the highest occurrence of suicide.

PI_NAMEs: BYERS, AMY LYNN (contact)

PROJECT_TERMS: Acute;acute care;Address;Adult;age group;aged;Aging;Award;Caring;Cessation of life;Characteristics;Clinical;clinical risk;cohort;Communities;comorbidity;Data;Data Set;Data Sources;Dementia;demographics;Development;Diagnosis;Drug Prescriptions;electronic health data;Emergency department visit;Emergent care;emerging adult;Employment;ethnic minority;Ethnic Origin;Financial Hardship;Firearms;frailty;Gender;gender minority;Growth;Health;health care service;high risk;Homelessness;Hospitalization;housing instability;human old age (65+);Imprisonment;Impulsivity;Individual;Inpatients;Interpersonal Violence;Intervention;Knowledge;Laboratories;late life;Life;Longitudinal cohort;Measures;Medical;Meditation;member;Methods;mild cognitive impairment;military veteran;Minority Groups;Modeling;mortality;multidisciplinary;multiple chronic conditions;novel;older adult;Older Population;Outcome;Overdose;Pathway interactions;patient oriented;person centered;personalized approach;Pharmaceutical Preparations;Policies;Population;Positioning Attribute;Poverty;Prevention;Prevention strategy;Probability;Productivity;Prognostic Factor;programs;prospective;Publishing;Race;racial minority;Research;resilience;Risk;Risk Factors;Safety;Science;sexual minority;social;social factors;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;systematic review;Techniques;Typology;Underrepresented Populations;Update;Veterans;Veterans Health Administration;Woman;Work

PROJECT_TITLE: Lethal Suicide Methods in Aging Veterans: Associated Profiles, Trajectories, and Transitions Informing Attempts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 MHBC-F (01)]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Phenotypic diversity allows pathogenic microbes and cancer cells to survive drug treatments and form permanent drug-resistance mutations, which poses a major challenge in medicine. It is not fully understood how phenotypic diversity contributes to collective biological functions, such as in biofilm formation and cancer metastasis. This project aims to address this general question by investigating bacterial collective migration, exploring how the diversity of phenotypes enables groups of bacteria to adapt across various physical environments and mediate pathogenesis.

PI_NAMEs: VO, LAM  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: acute infection;Address;Affect;Back;Bacteria;Behavior;Biological Process;cancer cell;cancer therapy;cell motility;Cells;Chemicals;Chemotaxis;chronic infection;commensal bacteria;Consumption;Disease;Drug resistance;Environment;Escherichia coli;Eukaryotic Cell;Exhibits;Exotoxins;Frequencies;Gene Expression;Genes;host colonization;Human;human pathogen;Immune;improved;Individual;Infection;insight;Knowledge;Laboratory Finding;Lead;Liquid substance;mathematical model;Measurement;Measures;Mediating;Medicine;Microbial Biofilms;Microbiology;Microfluidic Microchips;migration;Motility;Nature;Neoplasm Metastasis;new technology;New Territories;pathogen;Pathogenesis;pathogenic bacteria;pathogenic microbe;Performance;Pharmacotherapy;Phenotype;Physical environment;physical property;Polysaccharides;Population;population migration;Porosity;Positioning Attribute;predictive modeling;Process;Production;Pseudomonas aeruginosa;Reporter;resistance mutation;Running;Second Messenger Systems;sensor;Sepharose;Series;Sorting;Spatial Behavior;Speed;Structure;Surface;Swimming;Theoretical model;Time;trait;Travel;Type III Secretion System Pathway;Virulence;Virulence Factors

PROJECT_TITLE: Spatial organization of phenotypically diverse cells during collective migration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: Smoking is the leading cause of preventable illness, disability, and death in the United States. The rate of smoking is higher among Veterans with posttraumatic stress disorder (PTSD). Unfortunately, smoking cessation efforts that are effective in the general population have shown limited effectiveness in smokers with PTSD. We have successfully developed a treatment manual that provides evidence-based treatment for both PTSD and smoking at the same time. Contingency management (CM) is an intensive behavioral treatment that has significantly improved rates of stopping smoking in people with psychiatric disorders. CM provides positive reinforcers (e.g., vouchers, money) to Veterans who pass a biological test to show that they have not smoked since the last therapy session. This trial aims to test whether adding contingency management to combined PTSD and smoking cessation treatment will significantly increase treatment attendance and completion, greater reduction of PTSD and depressive symptoms, and greater rates of stopping smoking.

PI_NAMEs: DEDERT, ERIC A (contact)

PROJECT_TERMS: Abstinence;Aftercare;arm;Behavior Therapy;Behavioral;Biological Testing;Bupropion;Cessation of life;Cigarette;cigarette smoke;cigarette smoking;Clinic;Clinical Trials;Cognitive;Compensation;contingency management;Cotinine;Counseling;Data;depressive symptoms;disability;discounting;drug abstinence;Drug usage;effective intervention;Effectiveness;efficacy evaluation;evidence base;Evidence based treatment;experience;Fright;General Population;Goals;Guidelines;improved;Incentives;Individual;Intervention;long term abstinence;Manuals;Measures;Mediating;medical specialties;medication compliance;Mental disorders;Monitor;Morbidity - disease rate;mortality;negative affect;Nicotine;payment;Persons;Pharmaceutical Preparations;Population;Populations at Risk;Positive Reinforcer;Post-Traumatic Stress Disorders;Prevalence;prevent;programs;psychiatric symptom;Psychological reinforcement;Public Health;Randomized;reduce symptoms;Relapse;relapse prevention;Salivary;Self Efficacy;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking intervention;Smoking treatment;substance abuse treatment;substance misuse;Substance Use Disorder;substance use treatment;Symptoms;test strip;Testing;Therapeutic Intervention;Time;Trauma;Treatment Efficacy;United States;Veterans;voucher

PROJECT_TITLE: CPT-SMART for Treatment of PTSD and Cigarette Smoking


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Prevention;Primary Health Care

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE: Glycemic control is often the main of diabetes care, but a singular focus on glycemic control may lead to patients’ overall health and wellbeing being overlooked or undervalued. We have previously developed an intervention comprised of (a) a set of conversation cards designed to enable patients to identify aspects of life with diabetes important to them and to share them with their clinician to obtain their input; and (b) materials that help clinicians respond to patient concerns. We now propose to conduct a randomized clinical trial to test the feasibility of the research procedures and efficacy of the intervention with respect to patient reported outcome measures and for improving glycemic control.

PI_NAMEs: LIPSKA, KASIA JOANNA (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Achievement;Acute;Adverse effects;analog;Attention;Caring;Chronic;Client satisfaction;Clinical;Clinical effectiveness;clinical encounter;clinical outcome measures;Clinical Trials;Cluster randomized trial;Collection;Communication;comparison intervention;Complications of Diabetes Mellitus;contextual factors;cost;Data;Data Collection;design;diabetes control;diabetes distress;diabetes management;Diabetes Mellitus;Disease;Emergency Care;Enrollment;Event;feasibility research;feasibility testing;Future;glycemic control;Glycosylated hemoglobin A;Goals;Guidelines;Health;health care service utilization;Healthcare;High Prevalence;Hypoglycemia;improved;interest;Intervention;Life;Measures;medication administration;Methods;Minority Groups;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;Office Visits;Outcome;Outcome Measure;Participant;Patient Care;patient oriented;Patient Outcomes Assessments;Patients;Performance;Personal Satisfaction;Persons;Primary Care;primary care clinician;Procedures;programs;Psychosocial Factor;Qualifying;Quality of life;Questionnaires;Random Allocation;Randomized;randomized trial;randomized, clinical trials;recruit;Regimen;Research;response;Rewards;Safety;satisfaction;Self Management;social health determinants;success;Surveys;Testing;Time;treatment as usual;Treatment Efficacy;treatment planning;Visit;Work;Workload

PROJECT_TITLE: QBSafe: a randomized trial of a novel intervention to improve care for people living with type 2 diabetes.

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE U.S. efforts to End the HIV Epidemic have often overlooked cisgender women, who account for approximately 20% of new HIV diagnoses, and are routinely not engaged in HIV prevention services due to lack of knowledge and perceived risk- on the sides of both patient and provider- as well as insufficient integration of empowering HIV prevention counseling into routine woman-centered services, such as family planning services. Shared decision-making is a model that allows for discussion of all treatment options and empowers women to make informed health care decisions with consideration for their needs and preferences, usually through the use of a shared decision-making tool that decreases provider bias and increases provider knowledge while increasing the acceptability of care and counseling to the patient and the likelihood of adherence to the determined care plan. This adaptation of an evidence-based shared decision-making tool for use with HIV prevention in the high-reach setting of family planning clinics will provide scaffolding for improved HIV prevention counseling and increased HIV prevention method uptake, including novel and forthcoming modalities of pre-exposure prophylaxis (PrEP) for HIV prevention, advancing efforts to end the HIV epidemic among an underserviced at- risk population.

PI_NAMEs: ANDERSON, KATHERINE M (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Adult women;AIDS prevention;anxiety reduction;Area;Awareness;Behavioral;Belief;Black race;Caliber;career;Caring;Child;cis-female;cisgender;Client;Clinic;Clinical;Communication;Counseling;County;Decision Making;Development;effectiveness/implementation trial;empowerment;emtricitabine;Environment;Epidemic;ethnic diversity;Evaluation;evidence base;experience;Family Planning;feasibility testing;Female;Focus Groups;Fumarates;Funding;Future;Goals;Grant;Health Personnel;Healthcare;Heterosexuals;High Risk Woman;HIV;HIV diagnosis;HIV Infections;HIV risk;human centered design;implementation facilitators;implementation science;improved;infection rate;Information Dissemination;Injectable;interest;Intervention;Interview;Knowledge;Latinx;male;Measurement;Medical;medication compliance;Mentors;Mentorship;Method Acceptability;Methodology;Methods;Modality;Modeling;National Institute of Mental Health;novel;Oral;Organizational Decision Making;Pathway interactions;Patient Preferences;patient-level barriers;Patients;Physician's Role;pilot test;Populations at Risk;Postdoctoral Fellow;pre-exposure prophylaxis;preference;Prevention;prevention practice;Prevention Research;prevention service;Process;Provider;provider-level barriers;Quality of life;racial diversity;Regimen;Research;research and development;Research Personnel;Resources;Risk;Risk Factors;Sales;satisfaction;scaffold;Services;Sexual Health;shared decision making;Side;skills;social stigma;Strategic Planning;Techniques;Tenofovir;Testing;tool;Training;training opportunity;Training Support;transmission process;Trauma;United States National Institutes of Health;Universities;uptake;willingness;Woman;women of color;women's diagnosis;Women's Health;women's prevention;Work;World Health Organization

PROJECT_TITLE: Adaptation of a PrEP Shared-Decision Making Tool for Family Planning Clinics


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Compared to non-Hispanic Whites, Blacks carry a disproportionate burden of illness, disability, and early mortality. These health disparities have been linked to high levels of psychosocial stress experienced by Blacks, but the biological mechanisms linking stress with health disparities are not well understood. This project investigates the role of DNA methylation (changes that control genetic expression) in the connections between early life stress, protective factors, and health disparities in early markers of chronic disease in early childhood, late adolescence, and young adulthood.

PI_NAMEs: MRUG, SYLVIE  (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Accounting;Address;Adolescence;Adult;Affect;Age;Age disparity;age group;Alabama;Area;behavioral outcome;Biological;Black American;Black Populations;Black race;Blood Pressure;Body mass index;burden of chronic illness;burden of illness;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;caucasian American;Censuses;Child;Child Rearing;Chronic Disease;cohort;Collection;Communities;community-level factor;Cytosine;Data;Development;Diabetes Mellitus;Dinucleoside Phosphates;disability;Discrimination;Disease;disease diagnosis;Disparity;DNA;DNA Methylation;early childhood;Early Diagnosis;early experience;Early identification;early life stress;epigenetic marker;Epigenetic Process;epigenetic variation;Evaluation;experience;Exposure to;Female;fifth grade;follow up assessment;Genetic;genome wide methylation;Glycosylated Hemoglobin;Goals;Guanine;Health;health disparity;human old age (65+);Hyperglycemia;Hypertension;Individual;Inflammation;inflammatory marker;informant;inorganic phosphate;insight;Interpersonal Violence;Interruption;Intervention;Life;life span;Link;Longitudinal Studies;Measures;Methylation;Minority Groups;mortality;Neighborhoods;Not Hispanic or Latino;novel;Obesity;offspring;Outcome;Parents;postnatal;Poverty;Predisposition;prenatal;Preventive;prospective;protective effect;protective factors;Psychosocial Stress;Race;racial difference;racial disparity;racial health disparity;Recording of previous events;recruit;Reduce health disparities;Reporting;Rest;Risk;Role;Saliva;saliva analysis;sex;Site;social cohesion;Source;Stress;stressor;Temperament;transmission process;Variant;violence exposure;young adult

PROJECT_TITLE: Early Life Stress, DNA Methylation, and Health Disparities across Ages


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

PHR: Identifying efficacious drugs for the treatment of heart failure will save infant lives, but successful drug development in this population is dependent upon integration of growth, maturation, and disease specific influences on drug disposition and response. These factors are often ignored in infant heart failure trials. Our multidisciplinary team will systematically and efficiently characterize and validate the exposure-response relationship of the heart failure probe drug digoxin in infants with heart failure from single ventricle congenital heart disease; this disruptive approach is translatable to other therapeutics to broadly impact outcomes in this population.

PI_NAMEs: HORNIK, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: Acceleration;Accounting;Address;Adult;Affect;Age;Age Months;Area;ATPase inhibitory protein;Biological Markers;Brain natriuretic peptide;Cardiac;Cardiac Death;Cardiac Myocytes;Cardiac Surgery procedures;Cessation of life;Characteristics;Child;Childhood;Clinical;Clinical Data;Clinical Research;Collaborations;Complex;data access;Deformity;Development;Digoxin;Disease;Doctor of Philosophy;dosage;Dose;drug action;Drug Combinations;drug development;drug disposition;Drug Exposure;Drug Kinetics;Echocardiography;Environment;Equation;Event;experience;Failure;glomerular filtration;Goals;Growth;Half-Life;Heart failure;heart function;heart imaging;Heart Transplantation;Hospitalization;Image;imaging biomarker;improved;infancy;Infant;Infant Mortality;Injury to Kidney;Kidney;Knowledge;Measures;member;Metabolic;model development;Morbidity - disease rate;mortality;multidisciplinary;Myocardium;N-terminal;National Institute of Child Health and Human Development;neonate;Network Infrastructure;novel strategies;Outcome;Pathologic;Patients;pediatric heart failure;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Substance;Pharmacotherapy;Physiological;Plasma;Population;predictive modeling;Principal Investigator;prospective;Public Health;Recording of previous events;Renal function;Research;Research Institute;response;Retrospective Studies;Science;Single ventricle congenital heart disease;skills;Surrogate Markers;Symptoms;Therapeutic;therapeutic development;Therapeutic Index;Treatment Failure;Validation

PROJECT_TITLE: Digoxin Pharmacodynamics in Infants with Heart Failure due to Single Ventricle Congenital Heart Disease


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative: TPI Df is an untreatable metabolic disease. Overwhelming data demonstrate that disease pathogenesis is known to result from the targeting of functional mutant protein for degradation. Drug therapies do not exist for this disease. We propose to develop an optical compound screen to full high throughput screening standards, use the platform to screen FDA approved drugs, biologically active compounds, and a diversity compound library and identify the first in class TPI Df small molecule therapies. We will prioritize molecules using toxicology and metabolic stability assays, and validate the most promising compounds in TPI Df patient cells and in vivo using a mouse TPI Df model. Overall this project will discover and validate the first ever treatments for TPI Df that will provide the basis for clinical trials.

PI_NAMEs: PALLADINO, MICHAEL JOHN (contact);VOGT, ANDREAS

PROGRAM_OFFICER_NAME: PAWLYK, AARON C

PROJECT_TERMS: Acute;Amino Acid Substitution;analog;Anemia;Animal Model;Animals;Behavioral;Biological Assay;Blood;Brain;Brain Injuries;Catalogs;Cell Culture Techniques;Cell Line;Cell model;Cells;Cessation of life;Chemicals;Childhood;Chronic;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;combinatorial chemistry;Data;Databases;Defect;design;Development;Diagnosis;Disease;Dose;Drosophila genus;Drug usage;early childhood;efficacy testing;efficacy validation;Enzymes;Exhibits;FDA approved;Fibroblasts;fly;Foundations;Functional disorder;Genetic;Germ Lines;Goals;Heterozygote;high throughput screening;Human;human disease;Image;immunocytochemistry;Impairment;In Vitro;in vivo;Inpatients;insertion/deletion mutation;Intervention;Isomerase;Knockout Mice;Lead;lead series;Libraries;Library Collection Development;life span;Liver;liver metabolism;Longevity;Mammals;Mediating;member;Metabolic;Metabolic Diseases;Methodology;Missense Mutation;Modeling;Motor;mouse model;multicatalytic endopeptidase complex;Mus;Muscle;mutant;Mutation;Neurologic;neuromuscular;Neuromuscular Diseases;novel;novel therapeutics;Optics;Paralysed;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Pilot Projects;premature;Proteasome Inhibitor;protein degradation;protein function;Proteins;Quality Control;Research;response;Severity of illness;small molecule;small molecule libraries;Solid;Structure-Activity Relationship;Symptoms;System;Testing;Therapeutic;Therapeutic Agents;Toxic effect;Toxicology;transmission process;Triose-Phosphate Isomerase;Ubiquitin;United States National Institutes of Health;Universities;Validation

PROJECT_TITLE: Developing the first TPI Df therapeutics

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: While outcomes have been improved for many cancers, there remains a substantial need to develop and validate more effective treatments, while also improving the quality of life and well-being for cancer patients. The NRG Oncology National Clinical Trials Network (NCTN) group addresses this need, and the NRG Oncology Statistics and Data Management Center (SDMC) represents an integral component critical to ensuring that NRG Oncology clinical trials are properly designed, implemented, conducted, analyzed, and disseminated. This application seeks resources for the NRG Oncology SDMC to support the NRG Oncology and NCTN research agenda for the 2019-2024 program period. !

PI_NAMEs: DIGNAM, JAMES J. (contact);YOTHERS, GREG

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;ancillary care;Biological;Biological Markers;Brain;cancer clinical trial;Cancer Patient;cancer therapy;cancer type;Clinical;clinical trial analysis;Clinical Trials;Collaborations;Communities;Cooperative Group Program;Data Collection;Data Coordinating Center;data management;data sharing;design;Development;effective therapy;Ensure;follow-up;Gender;Goals;Head and neck structure;Human Resources;improved;Information Systems;innovation;Knowledge;Leadership;Life Cycle Stages;Lung;Maintenance;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;member;Methodology;Mission;Modality;Modernization;Monitor;National Clinical Trials Network;Oncology;operation;Outcome;Output;Personal Satisfaction;Phase;primary endpoint;programs;protocol development;Publications;quality assurance;Quality Control;Quality of life;Radiation therapy;Reporting;Research;Research Personnel;Resources;Role;secondary endpoint;Secure;statistics;success;Time;trial design;Upper digestive tract structure;Work

PROJECT_TITLE: NRG Oncology - Statistical and Data Management Center


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PI_NAMEs: DIGNAM, JAMES J. (contact)

PROJECT_TERMS: Adherence;Clinical Research;clinical trial analysis;Clinical Trials;Collaborations;Cooperative Group Program;Data;Data Coordinating Center;Databases;Decision Making;design;Development;Ensure;experience;follow-up;Geography;Goals;Human Resources;Lead;Leadership;Libraries;Malignant Neoplasms;member;Methodology;Mission;Monitor;National Clinical Trials Network;Oncology;oncology trial;operation;Pharmacologic Substance;primary endpoint;Procedures;Productivity;programs;Publications;quality assurance;Reporting;Research;Research Personnel;Research Support;Resources;secondary endpoint;Site;skills;statistics;Strategic Planning;Structure;success;Training;Work

PROJECT_TITLE: Admin Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative This project addresses some of the major challenges in the generation, purification and transplantation of human stem cell-derived midbrain dopamine neurons, challenges that currently limit the routine use of those neurons. The work will yield novel insights into brain development and establish techniques to facilitate human midbrain dopamine neuron production, purification and subtype specification in a dish. Our findings should have a broad impact and enable improved model systems to study and treat Parkinson's disease.

PI_NAMEs: BETEL, DORON ;STUDER, LORENZ P. (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Agreement;Automobile Driving;Behavior;Biological Models;Bradykinesia;Brain;candidate identification;Cell Line;Cell Separation;Cell Survival;Cell Therapy;Cell Transplantation;cell type;Cells;Chromatin;Clinical;clinical translation;Clinical Trials;Communities;Corpus striatum structure;CRISPR screen;Data;Derivation procedure;Development;differentiation in vitro;Disease;disease model;disease-in-a-dish;disorder subtype;Dopamine;dopaminergic neuron;Dose;drug discovery;Embryo;Enteral;Environment;fetal;fibroblast growth factor 18;first-in-human;Floor;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Generations;Genetic;genetic selection;Human;human disease;human induced pluripotent stem cells;human pluripotent stem cell;human stem cell-derived;human stem cells;improved;In Vitro;in vivo;induced pluripotent stem cell;insight;Knowledge;Laboratories;Location;Maps;Methods;Microglia;Midbrain structure;Modeling;Molecular;motor symptom;Movement Disorders;Mus;neural;Neuronal Differentiation;neuronal survival;Neurons;Noise;novel;Parkinson Disease;Pathway interactions;Patients;Phenotype;postnatal;Production;Property;Protocols documentation;Reporting;research clinical testing;Role;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Sorting;SOX6 gene;Specific qualifier value;Substantia nigra structure;Surface;Techniques;Technology;Testing;Transplantation;Tremor;Variant;Ventral Tegmental Area;Work

PROJECT_TITLE: Directing Fate, Subtype Identity and Survival in Human Pluripotent-Derived Midbrain Dopamine Neurons

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Therapy resistance in patients with metastatic melanoma is a significant clinical problem. The goal of this proposal is to understand how aggressive neural crest stem cell (NCSC)-like melanoma cells drive metastasis and therapy resistance. Mechanistic insight into the molecular vulnerabilities of NCSC-like melanoma cells is required for the development of clinically-relevant therapeutic strategies that can eliminate them to ablate metastases, overcome resistance and increase the overall survival of patients with advanced cancer.

PI_NAMEs: REBECCA, VITO WILLIAM (contact)

PROGRAM_OFFICER_NAME: VAHEDI, SHAHROOZ

PROJECT_TERMS: Ablation;Address;Advanced Malignant Neoplasm;Advisory Committees;Bar Codes;Bioinformatics;Biological;BRAF gene;Brain;Budgets;career;career development;Cells;Clinical;clinical development;clinically relevant;Combined Modality Therapy;Competence;Conflict of Interest;CRISPR/Cas technology;Data;Development;Educational workshop;Ensure;Faculty;FDA approved;Funding;Funding Agency;Future;Genetic;genetic signature;Genomics;Goals;Grant;Immunotherapy;In Vitro;in vivo;inhibitor;inhibitor therapy;insight;Intrinsic drive;Knock-out;Knowledge;Laboratories;Liver;Luciferases;Lung;Lysophosphatidic Acid Receptors;Manuscripts;Mediating;MEKs;Melanoma;Melanoma Cell;Mentored Research Scientist Development Award;Mentors;Metastatic Melanoma;Micrometastasis;Modeling;Molecular;mortality;multidisciplinary;mutant;Neoplasm Metastasis;neoplastic cell;Neural Crest;Neuronal Plasticity;novel therapeutic intervention;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phase;Phenotype;Positioning Attribute;preclinical study;Preparation;Productivity;programs;Proliferating;Property;Proteins;Proteomics;Relapse;Research;Resistance;response;responsible research conduct;RNA;RNA interference screen;Role;Secure;self-renewal;single cell analysis;single-cell RNA sequencing;standard of care;stem;stem cells;stemness;Subgroup;Systems Biology;targeted treatment;Techniques;Testing;Therapeutic;therapy resistant;Therapy trial;Time;Training;transcriptome sequencing;Translating;tumor;tumor ablation;Tumor Tissue;Tumor Volume;Validation;Work;Writing

PROJECT_TITLE: Dissecting clonal diversity in melanoma to overcome therapy resistance andmetastasis


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Vaccines have had a major impact on human health through the elimination of childhood diseases such as measles, diphtheria, whooping cough and polio. Safer, new generation vaccines are made from recombinant proteins instead of whole pathogens, but these require adjuvants to stimulate the immune system. Conventionally, only one type of adjuvant is used but they are more effective when combined. In this proposal we will used modern immunological tools to dissect the cellular and molecular pathways that underlie synergistic effect of adjuvants when combined.

PI_NAMEs: DAVIES, DAVID HUW (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Adaptive Immune System;adaptive immunity;Adjuvant;Agonist;Algorithms;Antibodies;Antibody titer measurement;Antigen-Presenting Cells;Antigens;Avidity;B cell differentiation;B cell repertoire;B-Cell Activation;B-Lymphocytes;Bacterial DNA;Behavioral;Biological Assay;biomarker identification;Calcium;CD4 Positive T Lymphocytes;cell motility;Cell Wall;Cells;Childhood;Computer Analysis;cross reactivity;cytokine;Data;Dendritic Cells;design;Diphtheria;Disease;draining lymph node;Ebola;Ebola virus;Emulsions;Filovirus;Flow Cytometry;Future;Gene Expression Profile;Generations;Genetic Markers;Genomics;Glycoproteins;Health;Heterogeneity;Homing;Human;Image;imaging approach;Imaging Techniques;Immune;immune imaging;Immune system;Immunity;immunogenicity;Immunoglobulin Class Switching;Immunologic Stimulation;Immunologics;Immunology;In Vitro;in vitro Assay;in vivo;Individual;Infection;Influenza;Influenza Hemagglutinin;Innate Immune Response;Innate Immune System;interdisciplinary approach;interstitial;IRF3 gene;Light;Link;Lipopolysaccharides;live cell imaging;Longitudinal Studies;Measles;Measures;microbial;Microscopy;Modeling;Modernization;Molecular;molecular marker;Molecular Profiling;Monitor;Motility;Mus;novel strategies;Oils;Outcome;pathogen;Pathway interactions;Pattern;Pattern Recognition;Pattern recognition receptor;Performance;Pertussis;Phenotype;Phosphorylation;Plasma Cells;Poliomyelitis;Proliferating;Property;Protein Microchips;Reaction;Recombinant Proteins;recruit;Reporter;Reporter Genes;response;SARS-CoV-2 spike protein;secondary lymphoid organ;Signal Pathway;Signal Transduction;single cell mRNA sequencing;single-cell RNA sequencing;Squalene;Stimulator of Interferon Genes;Structure of germinal center of lymph node;Sum;Surface Antigens;synergism;System;T-Cell Activation;T-Lymphocyte;TBK1 gene;Techniques;Technology;Testing;Tissue imaging;TLR4 gene;tool;transcriptome;transcriptomic profiling;transcriptomics;Transgenic Mice;Transgenic Organisms;two photon microscopy;two-photon;Vaccination;Vaccine Adjuvant;Vaccine Antigen;Vaccine Design;vaccine efficacy;vaccine immunogenicity;Vaccines;Vesicular stomatitis Indiana virus;Viral;Virus;Visualization;Water

PROJECT_TITLE: Defining molecular mechanisms of combination adjuvants: a systems immunology, transcriptomics and imaging approach


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis;Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Idiopathic pulmonary fibrosis (IPF) is a chronic, aging-associated lung disease characterized by the scarring of lung tissues, shortness of breath, and high mortality due to respiratory failure. This proposal is highly relevant for understanding the role of Epac1 protein in pulmonary fibrosis, and evaluate a small compound product to specifically inhibit Epac1. This proposal will lay the groundwork for developing a new therapy for the treatment of IPF.

PI_NAMEs: HADRI, LAHOUARIA  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Adenoviruses;Affect;aged;Aging;aging related;Attenuated;Biological Assay;Biological Process;Biopsy;Bleomycin;cardioprotection;Cardiovascular Diseases;Cell Adhesion;cell growth;Cells;Chest;Chronic;Cicatrix;comparison control;coronary fibrosis;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;cytokine;Data;Data Analyses;Development;Disease;effectiveness evaluation;Enzymes;experimental study;Exposure to;FGFR1 gene;Fibroblasts;Fibrosis;fibrotic lung;Foundations;FOXO3A gene;gain of function;genetic signature;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;Histology;Human;idiopathic pulmonary fibrosis;Immune response;Immunofluorescence Immunologic;In Vitro;in vivo;indium-bleomycin;Inflammation;Inflammatory;inhibitor;Interleukin-6;knock-down;Knockout Mice;Knowledge;Life;loss of function;Lung;Lung Diseases;lung injury;MADH2 gene;Malignant Neoplasms;Measurement;Messenger RNA;microCT;migration;Molecular;mortality;mouse model;Mus;myocardial injury;new therapeutic target;novel;novel strategies;novel therapeutics;old mice;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Pattern;pharmacologic;Phenotype;Phosphorylation;Population;Predisposition;Process;Profibrotic signal;Proliferating;promoter;Property;Proteins;Proto-Oncogene Proteins c-akt;Pulmonary Fibrosis;pulmonary function;Quantitative Reverse Transcriptase PCR;ras Guanine Nucleotide Exchange Factors;Regulation;Research;Respiratory Failure;Respiratory physiology;response;Role;Scanning;sensor;Severity of illness;Shortness of Breath;Signal Pathway;Signal Transduction;small hairpin RNA;STAT3 gene;Structure of parenchyma of lung;Tenascin;Testing;Therapeutic Effect;therapeutic target;Time;Tissue Sample;tool;transcription factor;transcriptome sequencing;Transforming Growth Factor beta;Western Blotting

PROJECT_TITLE: Role of Epac1 in the Pathogenesis of Pulmonary Fibrosis

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


PI_NAMEs: YOTHERS, GREG  (contact)

PROJECT_TERMS: Address;analytical method;Area;Biological Markers;cancer clinical trial;clinical trial analysis;Clinical Trials;Clinical Trials Design;Collaborations;Conduct Clinical Trials;Data Collection;Data Coordinating Center;data curation;data management;data sharing;design;Development;Disease;follow-up;Human Resources;Individual;Information Technology;innovation;Maintenance;member;Methodology;Methods;Mission;Modernization;Monitor;National Clinical Trials Network;novel;Oncology;oncology trial;operation;Patient Care;Phase;phase III trial;primary endpoint;Productivity;programs;protocol development;Publications;Reporting;Research;Research Personnel;Role;secondary endpoint;Secure;Site;statistics;timeline;trial design;Work

PROJECT_TITLE: Statistics Core


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Understanding the mechanisms whereby hepatocyte-secreted miRNA-containing extracellular vesicles (EVs) in mediating responses of insulin producing and insulin sensitizing cells, and how these are altered during the development of obesity, will provide a critical insight into the role of hepatic regulation on peripheral insulin sensitivity. In the future, therapeutic  treatments targeting hepatocyte EV miRNAs and their gene network may be developed to improve insulin sensitivity in obesity and Type 2 diabetic patients.

PI_NAMEs: YING, WEI  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Adipocytes;Adipose tissue;Anti-diabetic Drugs;Beta Cell;Cells;Circulation;Development;Diabetes Mellitus;diabetic patient;diet-induced obesity;disorder control;driving force;early-onset obesity;Endocrine;Epidemic;Exhibits;experimental study;extracellular;extracellular vesicles;feeding;Future;gene network;glycemic control;Hepatic;Hepatocyte;High Fat Diet;Homeostasis;Human;impaired glucose tolerance;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;insight;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;insulin sensitizing drugs;Knock-out;Macrophage Activation;Mediating;Medical;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolic syndrome;Methods;microRNA biomarkers;MicroRNAs;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Fibers;Non-Insulin-Dependent Diabetes Mellitus;novel;obese patients;Obesity;obesity development;obesity treatment;Pancreas;Pathogenicity;Patients;Peripheral;Play;Prediabetes syndrome;predictive marker;prevent;Proliferating;Regulation;Repression;response;Role;Skeletal Muscle;System;Therapeutic;Thinness;Thiouracil;Tissues;Transgenic Mice;Transgenic Organisms;Type 2 diabetic;vesicular release;Work

PROJECT_TITLE: Mechanisms by which hepatocyte extracellular miRNAs mediate peripheral insulin sensitivity

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Huntington's Disease;Mental Health;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Social Determinants of Health

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE This research will examine the structure, function and quality of social connectedness in patients with Huntington’s Disease (HD) and their adolescent and young adult offspring, in comparison with a sample of adolescents and young adults and their parents without HD. Our goal is to identify problems in the structure, function and quality of social connectedness in HD patients and their offspring and to study their association with quality of life and cognitive, emotional and behavioral problems associated with HD over a period of two years, and to examine bidirectional associations with two potential mediators of the association between social connectedness and health outcomes: executive functioning and emotion regulation. Findings from this study could inform future research to identify markers of HD risk early in development and guide the development of interventions to help slow the progression of symptoms of HD in this vulnerable group.

PI_NAMEs: CLAASSEN, DANIEL OLIVER;COMPAS, BRUCE E (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Acute;Adolescent;Adolescent and Young Adult;Adult;Adult Children;Adverse effects;Affect;Age;Anxiety;autosome;Behavior Therapy;Behavioral;biomarker identification;Cardiovascular Diseases;Caregiver Burden;Child;Child Rearing;Chronic;Cognitive;cognitive function;cognitive reappraisal;Communication;community engagement;Conflict (Psychology);Data;Development;Diabetes Mellitus;Diagnosis;Disease;Disease Progression;disorder risk;emotion regulation;Emotional;emotional functioning;Empirical Research;executive function;experience;Face;Family;follow-up;Future;Genes;Goals;Health;health related quality of life;Human;Huntington Disease;Impairment;Link;Loneliness;Malignant Neoplasms;Mediating;Mediator;member;Mental Health;Methods;motor impairment;Neurodegenerative Disorders;novel;Obesity;offspring;Outcome;Parent-Child Relations;Parents;Patients;physical conditioning;Problem behavior;Problem Solving;psychiatric symptom;psychologic;Psychosocial Factor;Qualitative Research;Quality of life;Research;response;Risk;Sampling;Severity of illness;Short-Term Memory;social;social factors;Social Network;social relationships;social stigma;Stress;Structure;Symptoms;Testing;therapy development;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Social Connectedness and Communication in Parents with Huntington''s Disease and their Offspring: Associations with Psychological and Disease Progression


NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Schizophrenia;Women's Health Research

ORG_DEPT: PSYCHIATRY

PHR: Many developmental disorders, including autism spectrum disorder (ASD) and Schizophrenia (SCZ), have a greater incidence in males than in females, and sex-dependent risk or protective factors have been postulated, but not yet identified. We hypothesize that early brain development differs in males versus females, and that inherited risk factors are mitigated in females by protective patterning in the developing female brain, at a developmental stage long before gonadal development. This project is seeking the first detailed understanding of early sexually dimorphic brain development, and will pioneer the discovery of how disease susceptibility depends on sex-biased gene regulation in the developing brain.

PI_NAMEs: VACCARINO, FLORA M (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Affect;Alzheimer's Disease;Anterior;ATAC-seq;Attention deficit hyperactivity disorder;autism spectrum disorder;Autopsy;Biological;Brain;cell type;Cells;Clinical;Code;Collection;Data;Data Set;design;Development;developmental disease;diagnostic development;Disease;Disease Outcome;Disease susceptibility;disorder risk;Embryo;Enhancers;Epigenetic Process;epigenome;epigenomics;Event;Extracellular Matrix;Female;fetal;Functional disorder;Gene Expression;Gene Expression Regulation;gene network;gene product;gene regulatory network;Genes;Genetic;Genetic Diseases;Genetic Enhancer Element;Genetic Markers;Genetic Risk;genetic risk factor;genetic variant;genome sequencing;genome wide association study;Gilles de la Tourette syndrome;Goals;gonad development;Gonadal Steroid Hormones;Hereditary Disease;Human;Human Development;human fetal brain;Incidence;Individual;induced pluripotent stem cell;Inherited;Intrinsic drive;Knowledge;Longitudinal Studies;male;Maps;Modeling;Molecular;multidisciplinary;Neurodevelopmental Disorder;novel therapeutic intervention;Organoids;Outcome;overexpression;Pathogenicity;Pattern;Peptides;Predisposition;Prevalence;proband;programs;protective factors;protein expression;Proteins;Proteome;Regulation;Regulatory Element;Research Personnel;Resolution;Risk;Risk Factors;risk variant;Schizophrenia;Severities;Severity of illness;sex;Sex Bias;Sex Differences;sexual dimorphism;Shapes;Testing;Time;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptome sequencing;trend;Untranslated RNA;Variant;virtual;whole genome;women versus men;Work

PROJECT_TITLE: Sex-specific trajectories in epigenomic regulation of brain patterning


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Biometry;Calendar;cancer clinical trial;Clinical;clinical trial analysis;Code;Collaborations;Computer software;Cooperative Group Program;Custom;Data;Data Collection;Data Coordinating Center;data harmonization;data management;data quality;data submission;Database Management Systems;Databases;design;Development;distributed model;Electronic Mail;Ensure;Environment;follow-up;Geography;Human Resources;Image;Imaging technology;Information Technology;Internet;Malignant Neoplasms;Medidata;member;Methods;Mission;National Clinical Trials Network;Oncology;operation;Performance;primary endpoint;Principal Investigator;Procedures;Process;Productivity;programs;protocol development;Protocols documentation;Publications;Qualifying;quality assurance;Quality Control;Radiation therapy;Reporting;Research;Research Design;secondary endpoint;software development;statistics;success;System;Systems Analysis;Testing;tool;web services;web-based tool;working group

PROJECT_TITLE: Data Management Core


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Childhood Obesity;Genetics;Human Genome;Nutrition;Obesity;Pediatric;Physical Activity;Prevention

ORG_CITY: BATON ROUGE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project Narrative The proposed research is relevant to public health because it will provide insights into epigenetic mechanisms of familial predisposition to obesity and may help to identify molecular markers of metabolic dysfunction in children. The proposed study is innovative because it utilizes state-of-the-art in vivo and in vitro approaches to establish the interaction of ancestral diet and exercise on transgenerational programming of mitochondrial dysfunction. The project is relevant to NIH mission that seeks acquisition of fundamental scientific knowledge, because it may lead to new diagnostic and therapeutic approaches for the early diagnosis, prediction and personalized interventions of metabolic disorders in children. .

PI_NAMEs: MURASHOV, ALEXANDER K. (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Adopted;Adverse effects;Affect;Animal Model;Biochemical;Bioenergetics;Brain;Calories;Cells;Child;Chronic;Closure by clamp;Complex;Conceptions;Consumption;Data;Development;diet and exercise;Drosophila genus;Early Diagnosis;Eating;Energy Metabolism;Environmental Risk Factor;Epigenetic Process;Exercise;Family;Fat Body;Feeding behaviors;Female;fly;Future;Genetic;genome-wide;Germ Cells;Glucose Intolerance;Heritability;High Fat Diet;Human;Impairment;In Vitro;in vivo;Inherited;innovation;insight;Intervention;Knowledge;knowledge base;Laboratories;life span;male;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Methodology;MicroRNAs;miRNA expression profiling;Mission;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;molecular marker;Molecular Target;Monitor;mortality;Motor Activity;mouse model;multiplex assay;Muscle;novel;novel diagnostics;novel therapeutic intervention;nutrition;Obesity;Obesity Epidemic;obesity in children;offspring;Permeability;personalized intervention;Phenotype;Physiological;Play;Pliability;Predisposition;Proteome;Proteomics;Public Health;Publishing;Research;Resolution;Risk;Role;sedentary;Somatic Cell;sperm cell;Spirometry;Techniques;Testing;Tissues;transcriptome sequencing;transcriptomics;transgenerational epigenetic inheritance;transmission process;United States National Institutes of Health;western diet

PROJECT_TITLE: Role of miRNAs in the transmission of metabolic risks

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Arthritis;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MANGILAO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF GUAM

ORG_STATE: GU

PHR: Project Narrative  This project will establish a Micronesian Data Laboratory at the University of Guam to conduct high-quality population-based surveys beginning with the first Guam National Health Interview Survey, with an emphasis on estimating gout and hyperuricemia prevalence. A Steering Committee and community partnership will be formed and engaged throughout the research process. The inaugural GNHIS findings will inform policy or program needs to support population health, generate future collaborative grant proposals, and serve as a model for other territories or USAPIs interested in NHIS or similar survey implementation. 1

PI_NAMEs: PAULINO, YVETTE C (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Accreditation;Address;Adolescent;Adult;Affect;Ankle;Applications Grants;Arthritis;Asian;Asian Pacific Islander;Asian population;Asthma;Chronic;Communities;community partners;community partnership;Consultations;COVID-19 pandemic;Data;Data Set;data space;design;Disease;Disparity;Emergency Situation;ethnic diversity;Ethnic Population;Exclusion;experience;Funding;Future;Gout;Government;Guam;Health;health data;health disparity;Health Surveys;Heavy Drinking;Household;Hyperuricemia;Information Technology;Infrastructure;instrument;interdisciplinary approach;interest;Interview;Interviewer;Island;Joints;Kidney Diseases;Knee;Knowledge;Laboratories;Language;Low Back Pain;Malignant Neoplasms;Measures;Michigan;Modeling;Names;National Health Interview Survey;Native Hawaiian or Other Pacific Islander;novel;Obesity;Pacific Islands;Pain;Policies;Population;population based;population health;Preparation;Prevalence;Probability Samples;Process;programs;Protocols documentation;psychological distress;Race;recruit;Reporting;Research;Research Activity;Sampling;Smoking;Strategic Planning;Surveys;Time;Toes;Training;training opportunity;United States;United States National Institutes of Health;Universities;Update;Uric Acid

PROJECT_TITLE: Establishing the Guma' Tinemtom to support population health research through island wisdom in Guam


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE This project aims to develop an engineered nanofiber-hydrogel composite with high biostimulatory activity that is capable of remodeling into vascularized soft tissue, and to understand materials properties and cellular responses governing optimal soft tissue remodeling in genetically tractable and established translational models. This study will yield a new series of off-the-shelf biostimulatory materials with high potential to repair craniofacial and other soft tissue losses in reconstructive surgery.

PI_NAMEs: JAMES, AARON W;MAO, HAI-QUAN ;REDDY, SASHANK K (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: adipose derived stem cell;Adipose tissue;Affect;Allogenic;angiogenesis;Animal Model;Autologous;Biocompatible Materials;caprolactone;care burden;Cell Communication;Cell Differentiation process;Cell Lineage;cell motility;Cell Therapy;Cells;Chemicals;Chemosensitization;Clinical;clinical translation;Collagen;conditioning;cost;Coupled;craniofacial;craniofacial repair;crosslink;Defect;density;Deposition;design;Development;Devices;Diameter;Disease;Dose;Engineering;Excision;Extracellular Matrix;Face;Fatty acid glycerol esters;feeding;Fiber;Fibrosis;Filler;Future;Goals;Health Care Costs;Hyaluronic Acid;Hydrogels;Immune response;Immunocompetent;immunoregulation;Implant;implantation;improved;in vivo;Infection;Infiltration;Inflammatory;Inflammatory Response;Inguinal region;Injections;insight;Kinetics;Length;lipid biosynthesis;mechanical properties;migration;Modeling;Molecular Weight;Morbidity - disease rate;mouse model;nanocomposite;nanoengineering;nanofiber;Nucleic Acids;operation;Oryctolagus cuniculus;Outcome;Paracrine Communication;Patients;Polyesters;Pre-Clinical Model;preclinical study;Property;Prosthesis;Proteins;PTPRC gene;Rattus;reconstruction;Reconstructive Surgical Procedures;recruit;regenerative;regenerative cell;repaired;response;restoration;Rodent Model;Role;Series;Site;soft tissue;Specific qualifier value;Speech;stem cells;Structure;Structure-Activity Relationship;subcutaneous;synergism;Testing;Time;Tissue Survival;Tissues;translational model;translational potential;translational study;Transplantation;Trauma;Vascularization

PROJECT_TITLE: Biostimulatory nanofiber-hydrogel composite for soft tissue remodeling

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Behavioral and Social Science;Pediatric;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative The Children's Hospital of Philadelphia Research Institute Summer Scholars Program (CRISSP) is focused on advanced skill development to ensure that the best and brightest advanced undergraduates (juniors and seniors) are fully prepared for careers in biomedical research with an emphasis on areas directly relevant to the mission of the NICHD. CRISSP, places these talented upper level undergraduate students in a rich pediatric-focused environment where they will receive direct hands-on research experience, didactic sessions and mentoring to not only inspire them to pursue careers in basic, translational and clinical pediatric research but also to develop advanced skills that are essential to performing cutting-edge research to promote the health and well-being of children and to propel them forward as leaders and innovators in child health research. The program emphasizes practical skill development, mentorship and underrepresented minority (URM) recruitment into the field.

PI_NAMEs: LOWENTHAL, ELIZABETH DAWN (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Adult;Area;Basic Science;Behavioral;Behavioral Research;Biomedical Research;Birth;career;Career Choice;Career Exploration;career preparation;Child;Child Health;Child health care;Child Support;Child Welfare;Childhood;Clinical;Clinical Research;Communication;curriculum enhancement;Dedications;design;Development;Development Plans;disability;Disease;early experience;Education;education research;Educational Curriculum;Educational process of instructing;Educational workshop;Elements;Ensure;Environment;experience;Exposure to;Faculty;faculty mentor;Family;Fostering;Funding;Future;Gifts;Goals;graduate school;Grooming;Growth;hands on research;Health;Health Promotion;Healthcare;implicit bias;improved;Individual;Infant;innovation;Institution;interest;Internships;Lead;Learning;medical schools;Medicine;Mentors;Mentorship;Minority Groups;Minority Recruitment;Mission;National Institute of Child Health and Human Development;Newborn Infant;next generation;Participant;Pediatric Hospitals;Pediatric Research;pediatrician scientist;Pediatrics;Pennsylvania;Personal Satisfaction;Philadelphia;Population;Procedures;Process;Productivity;programs;Qualifying;recruit;Rehabilitation therapy;Reproducibility;reproductive;Research;research faculty;Research Institute;Research Personnel;Research Project Grants;Research Technics;Research Training;Scholars Program;Schools;Science;Scientist;skill acquisition;skills;social;student training;Students;success;summer institute;summer internship;Supervision;symposium;Talents;Techniques;Training;Training Programs;Translational Research;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities

PROJECT_TITLE: Advancing Child Health: Preparing the Next Generation of Pediatric Researchers

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative C. albicans has become the third or fourth most common nosocomial bloodstream isolate; mortality rates are high (35% or greater) and treatment is costly. While antifungal compounds exist, these drugs are often of limited use because of their toxicity and side effects, and due to the emergence of antifungal resistance in the clinical setting. It is vital that C. albicans research continue as rapidly as possible – successful advance of this project, to provide a curated and comprehensive Candida albicans database, will continue to accelerate Candida research, and in doing so will aid in the fight against these fungal infections, significantly positively impacting human health.

PI_NAMEs: SHERLOCK, GAVIN J (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: 7 year old;Acceleration;Address;anti-fungal agents;Archives;Area;Base Sequence;Binding;Biochemical Pathway;Bioinformatics;Biological;Biological databases;Biology;Blood Circulation;Candida;Candida albicans;catalyst;ChIP-seq;Clinical;cloud based;Collection;Communities;community collaboration;comparative genomics;Complement;computational pipelines;Computer software;Computers;Conserved Sequence;cost;Coupled;Custom;Data;Data Analyses;Data Files;data mining;Data Set;Data Storage and Retrieval;data to knowledge;data visualization;Databases;Death Rate;Disease remission;Ensure;Environment;experience;Failure;fighting;Floods;Fungal Drug Resistance;Genes;Genome;genome annotation;genome browser;genome database;Genomics;graphical user interface;Health;high throughput technology;High-Throughput Nucleotide Sequencing;Hospitals;Human;improved;Infrastructure;Intuition;large scale data;Learning;Letters;Link;Literature;Location;Manuals;Maps;Medical;migration;Modeling;mortality;mutant;Mycoses;Names;novel;Ontology;Open Reading Frames;Paper;Pathogenesis;pathogenic fungus;Pharmaceutical Preparations;Phenotype;phenotypic data;Philosophy;Proteomics;public database;Publishing;reference genome;Research;Research Personnel;Resources;risk mitigation;Role;Running;Saccharomyces;Sepsis;Services;side effect;Site;success;Suggestion;Time;tool;Toxic effect;Transcript;transcription factor;transcriptome sequencing;Untranslated RNA;Update;virtual machine;Visit;Visualization;Work;Writing

PROJECT_TITLE: Candida Genome Database

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative This longitudinal mixed-methods study examines the effects of mobility status on developmentally salient health outcomes in Latino youth from migrant farmworker families across adolescence. Additionally, we assess how mobility levels may differentiate mental and physical health and substance use outcomes in youth who remain highly mobile versus those who become settled, and identify resilience factors that have potential to protect youth from poor health outcomes. Mitigating the consequences of migratory stressors on health trajectories and identifying protective factors during a critical transition time, when health disparities are expected to become increasingly prevalent, may be one of the most significant ways to promote health and well-being among migrant children in farmworker families.

PI_NAMEs: RUIZ, YUMARY ;TAYLOR, ZOE ELLEN (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Address;Adolescence;Adolescent;Affect;aged;Agriculture;Anxiety;Attention;Behavioral;Biological Markers;Buffers;Child;Child Welfare;Chronic;Communities;critical developmental period;Data;Development;Disadvantaged;Discrimination;Disparity;economic disparity;Education;Environment;Ethnic Origin;evidence base;experience;Face;Family;farm worker;Food;Future;Generations;Goals;Harvest;Health;health assessment;health disparity;Health Promotion;high risk;high risk behavior;Immigrant;improved;Indiana;Individual;interdisciplinary approach;Interruption;Intervention;Interview;Knowledge;Latino;Life;Link;Long-Term Effects;marginalization;Mediating;Mental Depression;Mental Health;Methods;Migrant;migration;Minor;Nature;novel;Obesity;Outcome;outcome disparities;Parents;Participant;Pattern;Personal Satisfaction;physical conditioning;Pilot Projects;Policies;poor health outcome;Population;Poverty;programs;protective factors;Public Health;Race;recruit;Reduce health disparities;Reporter;Research;Research Personnel;resilience factor;Risk;Risk Behaviors;Risk Factors;Role;rural area;rurality;School Drop-Outs;Seasons;social disparities;Societies;socioeconomics;stressor;Structure;Student Dropouts;substance use;Surveys;Testing;therapy development;Time;Travel;United States;Vulnerable Populations;Work;Workplace;Youth

PROJECT_TITLE: Mental and Physical Health in Children of Latino Migrant Farm Workers: A Multi-Level Longitudinal Examination of Risk and Resilience Factors

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Depression;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Maternal Health;Mental Health;Mental Illness;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: RALEIGH

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Project Narrative. Chronic exposure to a wide range of prenatal stressors including depression, financial stress, and adverse childhood experiences is more common among racial/ethnic minorities and may be causally related to obesity disparities in early life. Although epigenetic mechanisms are thought to mediate these processes, we lack sufficient supporting data in humans to guide policy. To identify early-acquired epigenetic mechanisms that link maternal social stress to metabolic dysfunction in children, and determine if a Mediterranean diet mitigates these effects, we will leverage existing cohorts of mothers and their children in Durham and Wake Counties in North Carolina, from 750 participants.

PI_NAMEs: HOYO, CATHRINE  (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Adherence;Adolescent;Adult;adverse childhood events;adverse pregnancy outcome;Affect;African American;Age;aged;Alanine Transaminase;Alleles;Animals;Anti-Inflammatory Agents;Antioxidants;Anxiety;Bioinformatics;Biological;Black race;Blood;Body mass index;cardiometabolic risk;Cardiovascular Diseases;Cardiovascular system;cell type;Cells;Central obesity;Child;Childhood;Cholesterol;Chronic;Chronic stress;Clinical;Clinical Trials;cohort;County;Cues;Cytosine;Data;density;Deposition;depressive symptoms;Desire for food;Diet;dietary adherence;dietary manipulation;Disease;Disparity;DNA;DNA Methylation;Early identification;Enrollment;Environment;Environmental Exposure;Epigenetic Process;epigenome;ethnic minority;Ethnic Origin;excessive weight gain;Exposure to;Fasting;Fatty acid glycerol esters;fetal;Financial Hardship;Fingerprint;Free Radicals;Functional disorder;Future;Gene Expression;Genes;Genetic;Genetic Variation;Genome;genome-wide;Genomic Imprinting;Germ Layers;Gestational Diabetes;H19 gene;Health;Hispanic;Hispanic Populations;Human;Hyperglycemia;Hyperlipidemia;Hypertension;IGF2 gene;imprint;in utero;Individual;insight;Intervention;Investigation;Knowledge;Life;Life Cycle Stages;Link;Liver Dysfunction;maternal anxiety;maternal depression;maternal risk;maternal stress;Measures;Mediating;Mediator;Mediterranean Diet;Mental Depression;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Methylation;methylation pattern;Minority Groups;Modification;Moods;mother nutrition;Mothers;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;North Carolina;novel;Nutrient;Obesity;obesity in children;offspring;Outcome;Oxidative Stress;Parents;Participant;Pathway interactions;perceived discrimination;Peripheral;peripheral blood;Policies;Pregnancy;Pregnant Women;prenatal;prenatal exposure;prenatal stress;Prevalence;Prevention;Process;Production;Proxy;Public Health;Publishing;racial minority;Records;Reporting;Resources;response;Risk;Risk Factors;Role;Sampling;Satiation;social adversity;social stress;social stressor;Specific qualifier value;Specimen;Stress;stressor;systemic inflammatory response;Testing;Tissues;Triglycerides;waist circumference;Woman

PROJECT_TITLE: Prenatal stress and diet, and the fetal epigenome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-G(55)]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: Narrative Researchers have documented health disparities between sexual minority and heterosexual individuals across hundreds of studies, but the investigations of why these disparities exist remain incomplete primarily because of the absence of a targeted contextual database that includes repeated measures of structural stigma and racism (legal and social climate) at multiple levels (i.e., tract, county, and state). This project will construct a database that will be linked to the National Longitudinal Study of Adolescent to Adult Health (Add Health). This database will enable researchers across multiple disciplines, including demography, economics, geography, psychology, public health, public policy, and sociology, to identify sources of health disparities and inform public health policies and interventions.

PI_NAMEs: JOYNER, KARA  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Adolescent;Adoption;Adult;adverse outcome;Advisory Committees;Anxiety;asexual;Attitude;Biological Markers;Bisexual;Cardiovascular Diseases;Characteristics;Charge;Cities;Climate;cohort;County;Data;data sharing;database design;Databases;Demography;design;Discipline;Discrimination;Disparity;Economics;Employment;Ensure;ethnic minority;ethnic minority population;Ethnic Origin;experience;Exposure to;Face;Fostering;Gays;Gender;gender diverse;Gender Identity;gender minority group;Geography;Goals;hate crimes;Health;health care availability;health disparity;Health Insurance;Health Policy;Heterosexuals;High Prevalence;improved;Individual;innovation;Institute of Medicine (U.S.);interest;intersectionality;Intervention;Investigation;Laws;Legal;Lesbian;Lesbian Gay Bisexual;Life Cycle Stages;Link;Longitudinal Studies;Malignant Neoplasms;Measurement;Measures;Mental Depression;minority children;minority health;minority stress;Modeling;National Longitudinal Survey of Adolescent to Adult Health;Neighborhoods;obesity risk;Outcome;Patient Self-Report;Persons;Physiological;Policies;Population;population based;population health;Population Heterogeneity;Positioning Attribute;Process;Productivity;Psychology;psychosocial;Public Health;Public Policy;Race;racial minority;racial minority population;racism;Research;Research Personnel;Respondent;response;Sample Size;Sampling;Sex Orientation;Sexual and Gender Minorities;Sexual Health;sexual identity;sexual minority;sexual minority group;sexual minority health;sexual minority health disparity;sexual minority status;social;Social Environment;social exclusion;social stigma;Societies;Socioeconomic Status;Sociology;Source;Statutes and Laws;Stigmatization;Structural Racism;Subgroup;Surveys;Testing;Time;transgender;United States;United States National Institutes of Health;Woman

PROJECT_TITLE: Contextual Determinants of Sexual Minority Health in the United States

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Atherosclerosis is one of the leading causes of mortality in the United States and reactive oxygen species have been shown to play a critical role in atherosclerotic plaque development. Clinical trials utilizing antioxidant therapies have been unsuccessful and we propose that nicotinamide nucleotide transhydrogenase (NNT) can reduce the development of atherosclerosis by regulating mitochondrial ROS production and preserving normal endothelial cell function. Results from these studies will highlight NNT as a master regulator of mitochondrial antioxidant activity and as a novel therapeutic target in the treatment of atherosclerosis.

PI_NAMEs: KRZYWANSKI, DAVID M (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Adhesions;Adipose tissue;Animals;antioxidant enzyme;antioxidant therapy;Antioxidants;Aorta;aortic arch;Arterial Fatty Streak;Atherosclerosis;Bioenergetics;Biological Availability;Blood Vessels;catalase;Cell Adhesion Molecules;Cell Physiology;Cell Respiration;Cells;chronic inflammatory disease;Clinical;Clinical Trials;Coronary Arteriosclerosis;CRISPR/Cas technology;Data;Development;Diabetes Mellitus;Disease;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;Equilibrium;Event;Functional disorder;Genes;genome wide association study;glutathione peroxidase;Glutathione Reductase;Heart failure;High Fat Diet;Human;Hydrogen Peroxide;Hypertension;Impairment;in vivo;Inflammation;Inflammatory;intercellular cell adhesion molecule;knock-down;Knockout Mice;Laboratories;Ligation;Lipids;Lipoproteins;Metabolic Pathway;Metabolism;Mitochondria;Modeling;Modification;Morbidity - disease rate;mortality;Mus;NAD(P)+ transhydrogenase;NADH;NADP;NADPH Oxidase;new therapeutic target;novel;obese patients;Obesity;overexpression;oxidant stress;Oxidation-Reduction;oxidized low density lipoprotein;Patients;Phenotype;Play;preservation;prevent;Production;Publishing;Reactive Oxygen Species;recruit;Regulation;response;Role;Serum;small hairpin RNA;success;System;Testing;therapeutically effective;trafficking;United States;Vascular Cell Adhesion Molecule-1;Vascular Diseases;Vascular Endothelial Cell;vascular inflammation;Viral

PROJECT_TITLE: Nicotinamide nucleotide transhydrogenase regulates redox balance in atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ORG_CITY: DURHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative (Public Health Relevance Statement)  Metastatic castration-resistant prostate cancer (mCRPC)—the most lethal form of prostate cancer with limited treatment options—is characterized by dysfunctional DNA repair, with 20%–30% of mCRPC bearing germline or somatic mutations in DNA repair genes, such as BRCA1/2 and others with deficiency in homologous recombination repair (HRR). Genetic or treatment-induced HRR deficiency renders cancer cells particularly vulnerable to inhibition of DNA-damage tolerance pathways, such as the Rev1-dependent translesion DNA synthesis (TLS). Hence, results from our proposed studies of TLS inhibition in mCRPC are highly relevant to public health as they will provide valuable insights into the development of new treatment modalities for patients with lethal mCRPC.

PI_NAMEs: HONG, JIYONG  (contact);ZHOU, PEI

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: absorption;acquired drug resistance;American;analog;androgen independent prostate cancer;Androgen Receptor;Androgen Suppression;Binding;BRCA deficient;brca gene;BRCA mutations;C-terminal;cancer cell;Cancer Etiology;cancer therapy;Cell Line;Cell Survival;Cells;Cessation of life;CHEK2 gene;Complex;cost;Data;Defense Mechanisms;design;Development;Diagnosis;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Repair Gene;DNA Sequence Alteration;DNA Synthesis Inhibition;DNA Synthesis Inhibitors;Drug Kinetics;Drug resistance;effective therapy;Effectiveness;enzalutamide;Evaluation;Excretory function;Family;FANCD2 protein;Fanconi Anemia Complementation Group A Protein;gene repair;Generations;Genes;Genetic;Germ-Line Mutation;Goals;homologous recombination;homologous recombination deficiency;hormone therapy;improved;improved outcome;In Vitro;in vivo;inhibitor;insight;Lead;Lesion;Ligands;Malignant neoplasm of prostate;Malignant Neoplasms;Mammalian Cell;Mediating;Medical;men;Metabolism;Modality;Modeling;mortality;Mus;Mutagenesis;National Cancer Institute;novel therapeutics;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Play;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;preclinical development;Property;prostate cancer cell;prostate cancer model;Prostate Cancer therapy;Proteins;Public Health;public health relevance;Receptor Signaling;recombinational repair;Regulator Genes;repaired;replication stress;Resistance;Route;Safety;scaffold;Scaffolding Protein;Shapes;Site;small molecule;small molecule inhibitor;Somatic Mutation;Structure;Structure-Activity Relationship;synergism;targeted agent;targeted treatment;Therapeutic;Toxic effect;tumor;tumor growth;tumor xenograft;United States;Xenograft procedure

PROJECT_TITLE: Inhibiting Rev1-mediated translesion DNA synthesis for cancer therapy

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: WASHINGTON

ORG_NAME: HOWARD UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE: HIV-associated neurological disorder (HAND) is significant comorbidity of HIV infection that persists despite effective anti-retroviral treatment. In this proposal, we will test an innovative hypothesis that HAND is caused by synergistic impact of HIV proteins, cocaine, and endothelial injury on the inflammasome activation and myeloid cells migration.

PI_NAMEs: JEREBTSOVA, MARINA A;NEKHAI, SERGEI  (contact)

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: Acute;Adaptor Signaling Protein;Anatomy;Anti-viral Response;antiretroviral therapy;Apoptosis;Attenuated;Blood Vessels;blood-brain barrier permeabilization;Brain;Brain region;CASP1 gene;cell motility;Cerebral endothelium;Cerebrovascular system;Chronic;chronic infection;Cocaine;Cocaine Dependence;cocaine exposure;comorbidity;Complex;cytokine;Development;Endothelial Cells;Endothelium;extracellular;Flow Cytometry;gag Gene Products;Gene Expression;Gene Silencing;Genes;Genetic Transcription;glial activation;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Hour;Human;IL18 gene;Impairment;In Vitro;Individual;Infection;Inflammasome;Inflammation;Inflammatory;injured;Injury;innovation;Interleukin-1 beta;Ions;Link;Location;Lung;Macrophage;Mediating;Membrane;methamphetamine exposure;Microglia;migration;mimetics;Modeling;monocyte;mouse model;Mus;Myeloid Cells;Nerve Degeneration;neuroAIDS;neurocognitive disorder;neuroinflammation;novel therapeutics;Older Population;Outcome;Pathogenesis;Pathway interactions;Patients;Persons;pharmacologic;Population;Prevalence;Production;protein complex;Proteins;Rattus;Reactive Oxygen Species;Reporting;Reverse Transcriptase Polymerase Chain Reaction;Reverse Transcription;Risk;Role;sensor;Signal Transduction;Stroke;substance use;Superoxide Dismutase;Testing;Transgenic Mice;Up-Regulation;viral detection;Viral Load result;viral RNA;Virus Replication;vpr Gene Products

PROJECT_TITLE: The Role of Endothelial Injury and Myeloid Cell Migration in the Activation of Inflammasomes in HIV infection and Cocaine Exposure

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 JRB-N (O1)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Human Genome;Precision Medicine;Prevention;Skin Cancer

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

PHR: ! Project Narrative This project seeks to identify people at high risk of a skin cancer such as melanoma, so these individuals can be monitored by a dermatologist. This Precision Prevention strategy would prevent cancers from reaching a lethal stage and reduce the health care cost of removing even rarely-lethal but invasive cancers. Predicting an individual's risk uses new methods for sampling skin non-invasively and measuring DNA adducts at ultrasensitive genomic sites, thereby objectively measuring a person's past exposure to ultraviolet light – the principal carcinogen leading to skin cancer. !

PI_NAMEs: BRASH, DOUGLAS E (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: adduct;Back;Basic Science;Behavioral Sciences;Bronchi;Cancer Detection;Cancer Etiology;cancer invasiveness;cancer prevention;cancer risk;carcinogenicity;Carcinogens;Caring;Cessation of life;Clinical;Cutaneous;Dermatologist;Diagnosis;Diagnostic tests;DNA;DNA Adducts;economic impact;Environmental Exposure;Environmental Risk Factor;Equilibrium;Exposure to;Fibroblasts;follow-up;Genome;genome-wide;Genomics;German population;Goals;Health Care Costs;high risk;high risk population;Human;Incidence;Individual;individualized prevention;innovation;keratinocyte;Lesion;Malignant Neoplasms;Measures;Mediating;melanocyte;Melanoma;Methods;Molecular Profiling;Monitor;Morbidity - disease rate;mortality;Mucous Membrane;Nature;Occupational Diseases;Persons;Population;precision medicine;Prevalence;prevent;Prevention;Prevention program;Prevention strategy;Probability;Pyrimidine Dimers;recruit;Reporting;Risk;Risk Factors;risk prediction;Route;Sampling;screening;Screening for cancer;Screening for Skin Cancer;Site;Skin;skin biopsy;Skin Cancer;Specialist;stem;Suggestion;Sun Exposure;surfactant;Time;Tissue Sample;Tissues;tumor;Ultraviolet Rays;UV Radiation Exposure;whole genome

PROJECT_TITLE: Applying Genomic Dosimeters of UV Damage to Predicting Skin Cancer Risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-J(55)R]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE Positron emission tomography (PET) is a highly specific and sensitive imaging technique that visualizes molecular interactions, having a significant impact on biomedical research and translational medicine. This proposal reinvents bismuth germanate (BGO) scintillator as an exciting scintillator that offers exceptional promise for time-of-flight (TOF) PET using its newly discovered “fast timing resolution”. Combining high sensitivity from TOF capability and no background radioactivity would be highly enabling for very low dose applications. The ability to perform TOF PET with BGO make it worthy of consideration for PET scanners designed for brain, breast, and total body imaging as well.

PI_NAMEs: KWON, SUN IL (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TITLE: Time-of-flight positron emission tomography using Cerenkov luminescence in bismuth germanate

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Emergency Care;Epilepsy;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Early treatment is vital for patients with status epilepticus to avoid preventable morbidity and mortality but there is evidence that the majority of patients fail to receive adequate prehospital care. Identifying the causes and clinical implications of this gap is critical for improving outcomes among patient with status epilepticus and has broader implications about the delivery of prehospital medical care overall.

PI_NAMEs: GUTERMAN, ELAN  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Affect;Benzodiazepines;Biostatistical Methods;California;Caring;Clinical;clinical decision-making;Clinical Trials;clinically relevant;Computerized Medical Record;cost;Critical Care;Data;Dedications;Dose;Early treatment;Emergency medical service;Ensure;evidence base;evidence based guidelines;examination questions;Failure;Focus Groups;Future;Goals;Guidelines;Hospital Administration;Hospital Records;Hospitalization;Hospitals;implementation science;improved;improved outcome;Information Systems;Inpatients;insight;Institution;Instruction;Intervention;Intubation;Link;Medical;Medical Records;Mentors;Morbidity - disease rate;mortality;Neuronal Injury;novel;Outcome;Patients;Persons;Pharmaceutical Preparations;Pre-hospital setting;Pre-hospitalization care;prospective;Protocols documentation;Provider;Qualitative Methods;Recommendation;Records;Refractory;Reporting;Research;Research Design;Research Methodology;Research Personnel;respiratory;Respiratory physiology;Risk;Seizures;service providers;skills;Status Epilepticus;Testing;Time;treatment and outcome;Treatment Protocols;Variant;Ventilatory Depression

PROJECT_TITLE: Prehospital management of status epilepticus

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Inflammatory Bowel Disease

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: NARRATIVE Recent discoveries have revealed that the half-lives and functions of sialylated glycoproteins at the cell surface can be regulated by their rates of de-sialylation with increased protein age. The neuraminidases responsible thereby control glycoprotein abundance and function among various cell types including epithelial cells of the intestine where they may participate in the onset of colitis. The research proposed in this application will determine whether Neu3 induction is involved in the onset of colitis in a mouse model of recurrent human food poisoning and will explore the role of protein sialylation in maintenance and erosion of the mucin barrier during intestinal inflammation and disease.

PI_NAMEs: MARTH, JAMEY  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Age;Aging;Alkaline Phosphatase;Anti-Inflammatory Agents;Bacterial Infections;Blood;Body Weight decreased;Cell surface;cell type;Clinical Trials;cohort;Colitis;Colon;colon bacteria;commensal bacteria;comparative;cytokine;Data;Development;Diarrhea;Disabling;Disease;disease model;Dose;Drug Metabolic Detoxication;Engineering;Enteral;enteric pathogen;Enterocytes;Environmental Risk Factor;Enzymes;Epithelial Cells;Epithelium;Family;Food Poisoning;foodborne illness;Frequencies;Functional disorder;Funding;gastrointestinal;Genetic;Glycoproteins;Gram-Negative Bacterial Infections;gut inflammation;Half-Life;Histopathology;Homeostasis;Human;Immune response;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inorganic phosphate;Intestinal Diseases;Intestines;Isoenzymes;Knockout Mice;Laboratories;Link;Lipopolysaccharides;Maintenance;Measurement;Measures;member;Membrane Glycoproteins;Modeling;Molecular;mouse model;Mucin-2 Staining Method;Mucins;Mus;Neuraminidase;novel;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Peptide Hydrolases;Play;Post-Translational Protein Processing;Predisposition;premature;Prevention;Protein Dephosphorylation;Protein Secretion;Proteins;Proteolysis;Publications;Publishing;Rectal Prolapse;Recurrence;recurrent infection;Regulation;Reporting;Research;Resistance;response;Role;Salmonella;Salmonella enterica;Salmonella typhimurium;Seasons;Sepsis;Serotyping;Sialic Acids;sialylation;Sialyltransferases;Spontaneous colitis;Stomach;Testing;Tissues;TLR4 gene;Ulcerative Colitis

PROJECT_TITLE: Protein Sialylation and De-Sialyation in Cell Surface Glycoprotein Homeostasis and Disease

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

PHR: Project Narrative The University of Notre Dame proposes to create a Post-baccalaureate Research Education Program (ND-PREP) to provide a one year pre-PhD biomedical research experience for individuals from underserved diverse backgrounds. The goal of ND-PREP is to provide Fellows with the research experience, professional development, and life skills necessary to gain admission to and succeed in competitive biomedical PhD programs. This goal will be achieved by providing the Fellows with a three-part formal training program that includes: 1) an intensive in-laboratory research experience (75% of trainee time); (2) a set of skills-development workshops and enrichment activities that will also serve to build a strong ND-PREP cohort (15% of Fellow time, with workshops ranging from research ethics to life skills); and (3) Fellow participation in a unique community engagement activity focused on lead abatement in the local community (10% of Fellow time).

PI_NAMEs: GOODSON, HOLLY V;MCDONALD, NYREE ;MCDOWELL, MARY A (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Abate;Admission activity;Anthropology;Arts;Biochemistry;Biological Sciences;Biomedical Engineering;Biomedical Research;Biophysics;career;Chemistry;cohort;college;Communities;community engagement;Community Outreach;Development;Doctor of Philosophy;Education;education research;Educational workshop;Engineering;Enrollment;Environment;experience;falls;Funding;Goals;graduate school;Institution;interest;Knowledge;Laboratory Research;Lead;Letters;Life;meetings;Mentors;Mentorship;mosaic;Participant;peer;Positioning Attribute;Postbaccalaureate;prevent;Process;programs;Psychology;Readiness;recruit;Research;Research Ethics;Science;skill acquisition;skills;success;support network;symposium;Time;tool;Training;Training Programs;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: University of Notre Dame Post-baccalaureate Research and Education Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Public Health Relevance This project examines evolutionary mechanisms from genomic and systemic perspectives, including studying a number of topics related to epistasis and pleiotropy. Because many of these topics are involved in human disease, are invoked in explaining disease prevalence, and/or help predict disease-causing mutations and mechanisms, understanding these phenomena sheds light on disease mechanisms and prevalence.

PI_NAMEs: ZHANG, JIANZHI  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Aging;Area;Biological Models;biological systems;Biology;Computer Simulation;Data Analyses;Dependence;Development;Disease;disease-causing mutation;driving force;Environment;environmental adaptation;Evolution;fitness;functional genomics;gene interaction;Genes;Genetic;Genetic Epistasis;Genetic study;Genome;Genomic approach;genomic data;Genomics;Human;human disease;Individual;Joints;laboratory experiment;Mammals;Maps;Molecular;Molecular Biology;Molecular Genetics;Mutation;Pattern;Phenotype;pleiotropism;Prevalence;Process;programs;public health relevance;Research;RNA Editing;Role;Technology;Testing;Theoretical model;Yeasts

PROJECT_TITLE: Genomic and systemic approaches to evolutionary mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Climate-Related Exposures and Conditions;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The proposed project seeks to train University of Utah undergraduate students from underrepresented racial/ethnic backgrounds in air pollution-related health research through the transdisciplinary faculty-mentored summer program Health, Air Pollution and Population Initiative in Education and Science Training (HAPPIEST). Exposure to air pollution is magnified in racial/ethnic minority communities, and it is thus critical to engage affected populations in this area of research. The proposed project's main contributions to public health are twofold: (1) HAPPIEST prepares underrepresented minority students to enter STEM research, thereby diversifying the pool of talented scientists; (2) the program advances knowledge in environmental health science thereby informing innovative solutions for air pollution-related health problems in the Salt Lake Valley and beyond.

PI_NAMEs: COLLINS, TIMOTHY WILLIAM;GRINESKI, SARA  (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Acute;Address;Affect;Air;Air Pollutants;Air Pollution;Altruism;anthropogenesis;Area;atmospheric sciences;Award;Back;Behavioral Sciences;biomedical scientist;cohort;Collaborations;commune;Communities;Community of Practice;Complex;data integration;Demography;design;Development;disadvantaged background;Education;Education Projects;Effectiveness;Engineering;environmental disparity;Environmental Engineering technology;Environmental Health;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;Evaluation;evidence base;Exposure to;Faculty;faculty mentor;Fostering;Future;Geography;Goals;Graduate Education;graduate student;Health;Health Sciences;higher education;Human;improved;innovation;interdisciplinary collaboration;interest;Knowledge;Life;Low Income Population;member;Mental Health;mentoring community;Mentors;minority communities;National Institute of Environmental Health Sciences;Neurologic;next generation;Participant;physical science;Physics;Pollution;Population;population health;programs;Psychiatry;Public Health;Pulmonology;Race;racial minority;racial minority population;racial population;recruit;reproductive;Research;research faculty;Research Personnel;Research Project Grants;Research Training;respiratory;Scholarship;Science;scientific atmosphere;Scientist;Social Behavior;social disparities;Sociology;Sodium Chloride;STEM research;Structure;student participation;Student recruitment;student training;Students;success;summer program;summer research;Talents;Temperature;Training;Training Programs;undergraduate research;undergraduate research experience;undergraduate student;underrepresented minority student;Underrepresented Populations;Underrepresented Students;Universities;university student;Utah;Work

PROJECT_TITLE: Health, Air Pollution, and Population Initiative in Education and Science Training (HAPPIEST)


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Opioids;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Placebos are powerful tools that modern medicine has often overlooked. This application seeks to understand the biological mechanisms through which antidepressant expectancies induce mood improvement.

PI_NAMEs: PECINA, MARTA  (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Address;Adult;Affect;anti-depressive agents;arm;Biological;blood oxygen level dependent;Brain;Buprenorphine;Chemosensitization;Clinical Trials;Corpus striatum structure;Data;design;disability;Dose;Double-Blind Method;drug development;Expectancy;expectation;experimental study;Failure;Functional Magnetic Resonance Imaging;Goals;Homosynaptic Depression;improved;Individual;insight;Investigation;Investments;Learning;Major Depressive Disorder;Mental Depression;Modeling;Modern Medicine;Molecular;Moods;Naltrexone;neural;neurofeedback;neuroimaging;new therapeutic target;novel;Opioid;Opioid agonist;Opioid Antagonist;Pain;pharmacologic;pill;placebo analgesia;Placebo Effect;Placebos;Prefrontal Cortex;Process;psychologic;Psychological reinforcement;Randomized;response;Rewards;Sensory;Signal Transduction;Testing;theories;Thinness;tool;Transcranial magnetic stimulation;treatment effect;treatment response;Update;Ventral Striatum

PROJECT_TITLE: Neurocomputational mechanisms of antidepressant placebo effects


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Maternal Health;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Narrative An estimated seven million yearly deaths are attributable to air pollution, with over 60% due to household air pollution (HAP) caused by use of biomass- or kerosene-fueled kitchen stoves in low- and middle-income countries. Women and children suffer the highest exposures, with documented ill effects on their respiratory, cardiovascular, and neurologic systems, along with mounting evidence of neurocognitive impairments in growing infants and children, due to HAP. The proposed work seeks to describe and quantify the risks of neurocognitive developmental impairment in relation to HAP with the goal of informing local and global public health policies and initiatives to reduce HAP.

PI_NAMEs: OLOPADE, CHRISTOPHER O (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 4 year old;8 year old;adverse pregnancy outcome;Affect;Africa South of the Sahara;Age;Air;Air Pollution;attributable mortality;Biological Markers;Biomass;biomass fuel;Blood;Brain;brain tissue;Breathing;Carbon Black;cardiovascular injury;Cardiovascular system;Cessation of life;Child;Chronic;Cognitive;cohort;Communities;cooking;Cookstove;cytokine;Deposition;deprivation;Development;early childhood;Enrollment;Ethanol;executive function;Exposure to;Fetal Development;Fetal Growth Retardation;fine particles;Future;Gases;Gestational Age;Goals;Grain;Growth;Health;Health Policy;Heavy Metals;Histologic;Home;Home environment;Household;Household Air Pollution;Hypertension;Hypoxia;Impairment;in utero;infancy;Infant;Inflammation;Inflammatory;Inhalation;injured airway;Kerosene;Language;low and middle-income countries;Low Birth Weight Infant;maternal stress;maternal wellbeing;Mediating;Micronutrients;Modeling;Monitor;Mothers;Motor;Nervous System Physiology;Nervous System Trauma;Neurocognition;Neurocognitive;Neurocognitive Deficit;Neurologic;Newborn Infant;Nigeria;Nigerian;Nutritional status;Outcome;Oxidative Stress;Oxidative Stress Induction;Oxygen;Particulate Matter;Performance;Personal Satisfaction;Placenta;Policies;pollutant;Pollution;postnatal;Pregnancy;Pregnancy Outcome;Pregnancy Trimesters;pregnant;Pregnant Women;Premature Birth;prenatal;programs;Psychosocial Stress;psychosocial wellbeing;Public Health;Questionnaires;Randomized;Randomized, Controlled Trials;Reporting;Research;respiratory;Risk;Risk Factors;Sampling;Second Pregnancy Trimester;Spontaneous abortion;Stress;System;systemic inflammatory response;Testing;Third Pregnancy Trimester;Translating;Validation;Variant;Vascularization;ventilation;Woman;Work

PROJECT_TITLE: Impact of household air pollution (HAP) in-utero through early childhood on neurocognitive development from infancy to 8 years (HAPCOG Study)