NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project narrative The limitation of druggable targets, the challenge of tumor heterogeneity and drug resistance to kinase inhibitors  in cancer therapy highlight the urgent need of developing new high-throughput drug screening strategies to  identify kinase modulators in complex cancer models. The objective of this proposal is to develop a novel multi pathway kinase activity assay and apply it to profile a large cysteine-reactive covalent fragment library in 2D and  3D cancer cell culture models to identify kinase modulator leads. The findings from this study hold promise to  not only advance kinase research overall, but also to identify candidate kinase modulators for future cancer drug  development.

PI_NAMEs: ZHANG, TIAN  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Affect;anti-cancer research;Antineoplastic Agents;Binding;Biological Assay;Cancer Biology;cancer cell;Cancer cell line;Cancer Model;cancer therapy;cancer type;candidate identification;career development;Cell Culture Techniques;Cells;Chemicals;chemotherapy;Communication;Communities;Complex;Cyclic AMP-Dependent Protein Kinases;Cysteine;Data;data acquisition;Drug Compounding;drug development;drug discovery;Drug resistance;drug resistance development;Drug Screening;druggable target;Elements;Ensure;Environment;experience;Foundations;Future;genetic regulatory protein;Goals;high throughput screening;high-throughput drug screening;Human;In Vitro;in vivo;Incubated;innovation;instrumentation;kinase inhibitor;knowledge base;Label;Lead;Leadership;Libraries;Ligands;Malignant neoplasm of ovary;Malignant Neoplasms;MAP Kinase Gene;mass spectrometer;Mass Spectrum Analysis;Measurement;Measures;medical schools;Mentors;method development;Methods;Modeling;Morphology;neoplasm resource;novel;Pathway interactions;Patients;Peptides;Phase;Phosphorylated Peptide;Phosphorylation;Phosphotransferases;Process;Protein Kinase;Proteome;Proto-Oncogene Proteins c-akt;Reagent;Reproducibility;Research;research and development;Research Personnel;response;Sampling;screening;Screening for cancer;Serous;Signal Pathway;Signal Transduction;skills;small molecule libraries;Solid;spheroids;System;targeted cancer therapy;targeted treatment;Technology;therapeutically effective;three dimensional cell culture;three-dimensional modeling;tool;Training;training opportunity;triple-negative invasive breast carcinoma;tumor;tumor heterogeneity;two-dimensional;Work;Writing

PROJECT_TITLE: A new multi-pathway kinase activity assay applied to compound library screening in cancer biology

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: SAN JUAN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: PROJECT NARRATIVE Several cell death types are involved in the pathogenesis of myocardial infarction and ischemia- reperfusion injury. This project will elucidate the role of ferroptosis, a recently discovered cell death mechanism, in cardiac dysfunction induced by ischemia-reperfusion. These studies will be useful for the development of new therapeutic strategies to mitigate cardiac ischemia-reperfusion injury by targeting ferroptotic cell death.

PI_NAMEs: TORRES-RAMOS, CARLOS A (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Accounting;antiporter;Apoptosis;Autophagocytosis;Biology;Cardiac;Cardiac Myocytes;cardioprotection;Cell Death;Cells;Cessation of life;Citric Acid Cycle;comparative;Complex;Coronary heart disease;coronary perfusion;Cysteine;Cystine;Data;Dependence;Development;dihydrolipoic acid;effectiveness evaluation;Endoplasmic Reticulum;Exposure to;Gases;Generations;Glutamates;glutathione peroxidase;Heart;heart damage;Image;Imaging Techniques;in vivo;inhibitor;innovation;Ions;Iron;Ischemia;ischemic injury;Lipoxygenase;Maps;mass spectrometric imaging;Mediating;Mitochondria;Modeling;Molecular;Morbidity - disease rate;mortality;Myocardial dysfunction;Myocardial Infarction;Myocardial Ischemia;Myocardial Reperfusion Injury;Myocardium;Necrosis;novel;novel therapeutic intervention;oxidation;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Pathogenesis;Phosphatidylethanolamine;Phospholipids;Play;Polyunsaturated Fatty Acids;prevent;Prevention;Process;Production;Reduced Glutathione;Reducing Agents;Reperfusion Injury;Reperfusion Therapy;Resolution;response;restoration;Role;selenoprotein;Severities;Severity of illness;Signal Transduction;specific biomarkers;Spectrometry, Mass, Secondary Ion;System;Techniques;Therapeutic;Therapeutic Intervention;therapeutically effective;treatment strategy

PROJECT_TITLE: Mitochondria-mediated mechanisms of ferroptosis in response to cardiac ischemia-reperfusion injury


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Molecular classification has transformed the diagnosis and treatment of brain tumors and created promising avenues for targeted therapies. However, the molecular makeup of brain tumors remains difficult to access and apply to patient care in an effective and timely fashion. Through this academic-industrial partnership, we aim to develop and validate a means of unlocking the key genetic alterations in brain tumors through optics and artificial intelligence that could improve patient care.

PI_NAMEs: ORRINGER, DANIEL  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Adjuvant Therapy;algorithm training;Algorithms;Artificial Intelligence;artificial intelligence algorithm;Artificial Intelligence enhanced;Artificial Intelligence platform;ATRX gene;automated algorithm;Biopsy;Brain Neoplasms;central database;Classification;Clinical;Clinical Data;clinical translation;Clinical Trials;Clinical Trials Design;Complex;Computer software;convolutional neural network;Data;data exchange;data pipeline;deep neural network;design;Development;Diagnosis;Diagnostic;diagnostic screening;Diffuse;digital data;Epigenetic Process;Excision;feature extraction;Genetic;Glioma;Goals;graph neural network;Guidelines;Histologic;histological image;Histology;Human;Image;imaging system;improved;industry partner;Infrastructure;Institution;Label;learning strategy;Link;long short term memory;Malignant Neoplasms;Medicine;Methods;Microscopic;Molecular;Molecular Diagnosis;molecular diagnostics;molecular marker;Morphology;Multi-Institutional Clinical Trial;Mutation;Natural Language Processing;Nature;Operating Rooms;Operative Surgical Procedures;Optics;Pathology;Pathology Report;Patient Care;Patients;prediction algorithm;prospective;Radiation Tolerance;repository;self supervised learning;Specimen;Study Subject;System;targeted treatment;Time;Training;Training and Infrastructure;tumor;tumor diagnosis;Work

PROJECT_TITLE: Clinical Translation of Stimulated Raman Histology


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Kidney diseases affect 37 million people in the United States. Despite recent advances in treatment options, there remains an urgent unmet need to identify new therapeutic targets and treatments to bend the arc of kidney diseases and reduce these staggering numbers. The Northwestern University National Resource Core Center (NU-NRC) will harness the power of the physical sciences to provide innovative platforms, new approaches and reagents to kidney researchers to enable new solutions and find cures.

PI_NAMEs: GEORGE, ALFRED L.;QUAGGIN, SUSAN E. (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Affect;American;Area;bioelectronics;Biological Products;Biomedical Engineering;biomedical resource;Biosensor;Budgets;California;cardiovascular risk factor;care costs;Career Choice;cell type;Cells;Cessation of life;Chemistry;Communicable Diseases;Communication;Communities;comorbidity;cost;Coupling;Dedications;design;Development;Diagnostic;Discipline;Disease;Education;Educational workshop;Emerging Technologies;Ensure;Event;Exposure to;functional genomics;gene function;gene therapy;Goals;high school program;High School Student;Home;Homing;Human;Image;In Vitro;in vivo;Incidence;Incubators;Individual;innovation;intercalation;Internships;Investigation;Ions;Kidney;kidney cell;Kidney Diseases;Kidney Failure;Label;Mass Spectrum Analysis;Medicare;Medicine;Mentors;Mentorship;Methods;minority communities;Mission;Molecular;Monitor;nanocarrier;nanoparticle;nanoscale;Nanotechnology;new technology;new therapeutic target;novel strategies;novel therapeutics;Oncology;operation;Organ;Pathogenesis;Patient Care;Persons;Pharmaceutical Preparations;Phenotype;physical science;Physiologic Monitoring;Political Factor;programs;protein function;Proteins;Proteomics;Reagent;Renal function;Research;research and development;Research Personnel;Resource Development;Resources;Risk;RNA;Science;Scientist;screening;Services;Skin;small molecule;social factors;Structure;Students;success;Talents;Technology;theories;Therapeutic;therapeutic development;therapeutic target;Time;Tissue imaging;Tissues;tool;United States;Universities;Vaccines;Vision

PROJECT_TITLE: Northwestern University O'Brien Kidney National Resource Center


NIH_SPENDING_CATS: Kidney Disease

PI_NAMEs: QUAGGIN, SUSAN E. (contact)

PROJECT_TERMS: Adopted;biomedical resource;Collaborations;Communication;Communities;design;Development;Discipline;Drug Delivery Systems;Education;Educational workshop;Ensure;Evaluation;Event;experience;Fostering;Funding;Goals;Healthcare;high school;Information Centers;Infrastructure;International;Justice;Kidney;Lead;Leadership;meetings;Methods;Mission;Modeling;Monitor;Nanotechnology;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of General Medical Sciences;Oncology;outreach;physical science;Principal Investigator;Procedures;Process;programs;Publications;Recruitment Activity;Research;Research Personnel;Resource Allocation;Resource Development;Resource Sharing;Resources;Science;Scientist;Source;Structure;Students;summer student;symposium;synergism;Talents;Technology;technology development;timeline;Training;Training Activity;training opportunity;Universities;web portal;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Sleep Research

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Successful completion of the proposed experiments will characterize the role of astrocytic circadian clock in regulating synaptic rhythmicity and cognitive performance. There is a strong comorbidity between disruptions to the circadian cycle, and cognitive impairments, yet the mechanistic link is not well understood. We will examine how astrocytic molecular clock regulates time-of-day-dependent changes in synapse number and activity, determine the mechanisms controlling its function, and identify the rhythmic astrocytic factors that can be targeted to correct clock-related cognitive deficits.

PI_NAMEs: FARHY, ISABELLA  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;AMPA Receptors;Area;ARNTL gene;Astrocytes;Behavior;Brain;Brain region;Calcium;Calcium Signaling;cell type;chordin;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;Cognition;Cognition Disorders;Cognitive;Cognitive deficits;cognitive function;cognitive performance;cognitive process;comorbidity;Data;differential expression;Disease;Eating;epidemiology study;Exhibits;experimental study;Functional disorder;Future;Genes;Genetic;Glutamates;Glypican;Harvest;Health;Hippocampus;Human;Hypothalamic structure;Impaired cognition;in vivo;Investigation;Knockout Mice;Knowledge;Learning;Life Style;Light;Link;Maintenance;Mass Spectrum Analysis;Mediating;Memory;Memory impairment;memory process;Mental Depression;Modernization;Molecular;molecular clock;Mus;Nature;Nervous System Disorder;Neuroglia;Neurons;novel;Periodicity;Persons;Population;Prevalence;Process;Production;Prosencephalon;Protein Secretion;Proteins;Proteome;Publishing;receptor expression;Regulation;Research;Role;shift work;Sleep;Sleep disturbances;sleep pattern;Stress;suprachiasmatic nucleus;Synapses;synaptic function;Testing;Time;Travel;Work

PROJECT_TITLE: Regulation of Synaptic Rhythmicity by Astrocytic Clock

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


PI_NAMEs: CHUNG, EUN JI PAIGE (contact)

PROJECT_TERMS: Address;Adult;Architecture;Award;Biomedical Engineering;biomedical resource;cell type;Cells;Chemistry;Collaborations;Communities;Complex;Data;Data Analyses;Deposition;design;detection method;Development;Ductal Epithelial Cell;Ecosystem;Engineering;Ensure;Fostering;functional genomics;galactose receptor;Genome;genome-wide;Goals;Health;Human;IgA Deficiency;IGA Glomerulonephritis;Image;improved;in vivo;Incubators;Individual;innovation;interdisciplinary approach;Ions;Kidney;kidney cell;Kidney Diseases;Label;Leadership;Maps;Mass Spectrum Analysis;mesangial cell;Methods;Microfluidics;MicroRNAs;Mission;nanocarrier;nanomedicine;nanoparticle;nanoscale;Nephrons;Phenotype;physical science;Pilot Projects;podocyte;prevent;Proteins;Research;Research Personnel;Resolution;Resource Development;Resources;response;RNA;Scientist;Series;single cell technology;siRNA delivery;Surface;Technology;Testing;therapeutic target;Tissue imaging;Tissues;Universities;Validation;Work

PROJECT_TITLE: Resource Development Core


PI_NAMEs: SCOTT, EVAN ALEXANDER (contact)

PROJECT_TITLE: Biomedical Resource Core


ORG_CITY: PHILADELPHIA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative Oncogenic human viruses are associated with many human malignancies. The mechanisms regulating transcription and replication in hypoxia is not well investigated. This program will explore their strategies for control in establishing long-term viral infection and will provide new clues for development of targeted therapies for treatment of the associated cancers.

PI_NAMEs: ROBERTSON, ERLE S. (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Address;Antigens;Area;Automobile Driving;Basic Science;Biochemistry;Bioinformatics;Biological Assay;Biology;burden of illness;Burkitt Lymphoma;Cell Culture Techniques;Cell Differentiation process;Cell Line;Cell Physiology;cell transformation;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;data management;Development;Disease;DNA Sequencing Facility;Endothelium;Environment;Enzymes;Epigenetic Process;epigenome;Epstein-Barr Virus latency;Event;experience;gammaherpesvirus;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;Genome;Goals;Guide RNA;Herpesviridae;HIF1A gene;HIV;Hodgkin Disease;Human;Human Herpesvirus 4;Human Herpesvirus 8;Hypoxia;Immunocompromised Host;Infection;insight;Interdisciplinary Study;Intervention;Kaposi Sarcoma;knock-down;Knock-out;Laboratories;Lentivirus;Libraries;Link;Lymphoma;Lymphoproliferative Disorders;Maintenance;Malignant Neoplasms;Mediating;Merkel cell carcinoma;Merkel Cells;Mesenchymal;Mesenchymal Stem Cells;Metabolic;Metabolism;Modeling;Multicentric Angiofollicular Lymphoid Hyperplasia;multidisciplinary;mutant;Nasopharynx Carcinoma;Nature;neoplastic cell;next generation sequencing;Non-Hodgkin's Lymphoma;novel;Nucleotides;Oncogenic;Oncogenic Viruses;Oncology;Oxygen;Pathway interactions;Patients;Pennsylvania;Phenotype;Play;Pleural effusion disorder;Polyomavirus;post-transplant;preclinical development;preclinical study;prevent;Production;programs;Proteins;Reagent;Recombinants;Regulation;Research Personnel;response;Role;Sampling;skills;Skin;small hairpin RNA;success;System;targeted treatment;therapeutic development;Therapeutic Intervention;therapeutically effective;translational potential;Translational Research;Transplantation;Treatment-Related Cancer;tumorigenesis;Universities;vector;Viral;viral carcinogenesis;Viral Pathogenesis;Virus;Virus Diseases;Virus Inhibitors;virus related cancer

PROJECT_TITLE: Transcription and Replication of Oncogenic Viruses in Hypoxia


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: Narrative: KSHV is an important pathogenic oncovirus associated with human cancers. Kaposi’s sarcoma (KS) and pleural effusion lymphomas (PELs) are tightly linked to KSHV-infection, seen in immunocompromised individuals, as well as endemic populations. This study aims to understand the replication of KSHV, and to elucidate the molecular mechanisms that drive persistence of KSHV in daughter cells in the hypoxic microenvironment of associated cancers. 15

PROJECT_TERMS: Address;Animal Model;Antigens;Automobile Driving;B-Lymphocytes;Biological Assay;Cell Culture System;Cell Cycle;Cell Cycle Proteins;Cell Hypoxia;Cell Line;Cell Proliferation;Cell Reprogramming;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Cytoprotection;Data;daughter cell;Development;DNA biosynthesis;DNA Viruses;Drug Targeting;Endothelial Cells;Environment;Enzyme Induction;Enzymes;Epigenetic Process;Etiology;Family;Generations;Genes;Genetic Transcription;Genome;Goals;Harvest;Herpesviridae;Herpesviridae Infections;HIF1A gene;Human;Human Cell Line;Human Herpesvirus 8;Hypoxia;Immunocompromised Host;In Vitro;Incubated;Individual;infected B cell;insight;Kaposi Sarcoma;knock-down;Knock-out;Lesion;Link;Lymphoma;Lymphoproliferative Disorders;lytic replication;Malignant Neoplasms;Mediating;member;Metabolic;Metabolism;Modification;Molecular;Multicentric Angiofollicular Lymphoid Hyperplasia;normoxia;novel;Nucleotides;Oncogenic Viruses;Oncornaviruses;Pathogenicity;Pathology;Pathway interactions;Phase;Pleural effusion disorder;Population;Post Translational Modification Analysis;Post-Translational Protein Processing;Predisposition;primary effusion lymphoma;Production;programs;Proteins;Proteomics;Regulation;Role;small hairpin RNA;Stress;System;Tetanus Helper Peptide;three dimensional cell culture;Time;Transcriptional Regulation;transcriptome;Translations;tumorigenesis;Viral;Viral Antigens;Viral Genome;Virus;Virus Latency;virus related cancer;Virus Replication;Western Blotting

PROJECT_TITLE: Project 1: KSHV reprograms replication and metabolic activities in hypoxia


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Mental Health;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Emerging data suggests that SARS-CoV-2 infections may lead to neurocognitive deficits, which can have a duration of at least a year post-infection, and are thereby very distressing. We have been following a cohort of 650 patients since discharge from our hospital, who were previously cognitively normal, and for whom 30% of returning subjects have progressive cognitive decline. Here we propose to follow and thoroughly investigate these subjects to answer these critical questions: (1) what are the characteristics of COVID-19 induced neurocognitive dysfunction, including its duration and anatomic localization; (2) what are its risk factors, including possibly sex, age, race/ethnicity and medical comorbidities; and, (3) what is the role of persistent inflammation in producing it, which is vital because a positive finding would lead immediately to trials of anti-inflammatory interventions for this devastating disorder.

PI_NAMEs: SCHULZ, PAUL E (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: 2019-nCoV;Address;Age;age effect;Anatomy;Anti-Inflammatory Agents;Anxiety;Attention;Basic Science;biobank;Biological Markers;Blood;brain size;Cerebrospinal Fluid;Characteristics;Cognitive;cognitive change;cognitive testing;Cognitive Therapy;cohort;comorbidity;comparison control;COVID-19;COVID-19 mortality;COVID-19 neurocognitive sequelae;Data;Development;digital;Disease;Distress;Ethnic Origin;executive function;Exhibits;Female;Functional disorder;Functional impairment;global health;Goals;gray matter;Hospitalization;Hospitals;Image;Immunoglobulin Therapy;Immunosuppressive Agents;Impaired cognition;Induced Neurons;Infection;infection rate;Inflammation;Inflammatory;inflammatory marker;Infrastructure;innovation;Institution;Intervention;Intravenous Immunoglobulins;Lead;Learning;Link;Medical;Medical Records;Memory;Mental Depression;Mood Disorders;Neurocognitive;Neurocognitive Deficit;neuroinflammation;Neurologic;Neurologic Symptoms;Neurons;neuropsychiatric disorder;neuropsychiatry;Neuropsychological Tests;older adult;older patient;pandemic disease;Participant;participant enrollment;Pathway interactions;Patients;Peripheral;Persons;Plasma Exchange;Positron-Emission Tomography;post-COVID-19;Probability;processing speed;prospective;Quality of life;Race;Reporting;Research Personnel;Risk;Risk Factors;Role;SARS-CoV-2 infection;screening;Screening procedure;Serum;severe COVID-19;sex;Stress;Stroke;Survivors;tau-1;Testing;therapy design;Thick;Time;Translational Research;treatment research;Underrepresented Populations;verbal;Work

PROJECT_TITLE: Mechanisms underlying COVID-19 induced Neurocognitive Dysfunction

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: DURHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Castration-resistant prostate cancer (CRPC) is a lethal disease demanding new treatment strategies. Aggressive phenotypes and/or therapy failure seen in CRPC patients have been linked to the increased tumor cell metabolism and an androgen receptor (AR) splicing variant termed AR-V7, both of which are correlated with poorer prognosis in the clinic. However, the mechanisms underlying altered tumor metabolism and AR-V7- releated oncogenic programs in CRPC are far from clear. Our recent preliminary studies point to YY1, a zinc finger transcription factor showing significant overexpression during disease progression of CRPC. YY1 maintains high expression of both metabolic genes and the AR-V7-related gene targets. YY1 thus constitutes a completely new mechanism that might account for major malignant alterations in metabolism and androgen signaling seen in CRPC. The current proposal will explore this novel mechanism that underscores CRPC progression and therapeutic resistance. The successful completion of the proposed research shall allow a deeper understanding of how the terminal CRPC disease progresses and will help to rationally develop novel strategies to treat the affected patients. Thus, this proposal is significant, innovative and may potentially translate into the clinic to improve CRPC treatment.

PI_NAMEs: CAI, LING  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: advanced prostate cancer;Affect;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;Androgens;ATAC-seq;Binding;Binding Sites;BRD2 gene;Bromodomain;Cancer Patient;cell growth;Cell Line;Cell model;Cells;ChIP-seq;Chromatin;Clinic;Clinical;clinically relevant;cofactor;cohort;Complex;Data;Data Set;Development;Disease;Disease Progression;DNA Binding;enzyme pathway;Enzymes;experimental study;Gene Activation;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic Transcription;Genetically Engineered Mouse;genomic profiling;Genomics;Glycolysis;Glycolysis Pathway;Goals;Growth;Hormones;improved;In Vitro;in vivo Model;inhibitor;innovation;insight;knock-down;Left;Link;LNCaP;loss of function;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Maps;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Modeling;Molecular;mouse model;Mus;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenic;Outcome;overexpression;Pathway interactions;Patients;pharmacologic;Phenotype;Primary Neoplasm;Prognosis;programs;prostate cancer cell;prostate cancer cell line;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;prostate carcinogenesis;Prostatic Neoplasms;Proteins;Receptor Signaling;recruit;Research;Resistance;RNA Splicing;Role;Sampling;Side;Signal Transduction;Site;standard care;targeted agent;Terminal Disease;Testing;Therapeutic;therapy development;therapy resistant;TP53 gene;transcription factor;transcriptome sequencing;Translating;Treatment Failure;tumor;tumor metabolism;Tumor Promotion;Tumorigenicity;Validation;Variant;VCaP;Warburg Effect;YY1 Transcription Factor;Zinc Fingers

PROJECT_TITLE: The Role of YY1 in Castration-Resistant Prostate Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: Narrative Evidence from our recent study suggests that Kaposi’s sarcoma (KS) originates from oral mesenchymal stem cells (MSCs) through KSHV-induced mesenchymal-to-endothelial transition (MEndT). In this proposal, we will investigate the hypothesis that KSHV hijacks the cellular intrinsic hypoxia response to drive MSC to special lineage differentiation and commit oncogenesis. This study will provide mechanistic insights into how KSHV promotes MSC MEndT and oncogenic properties leading to KS.

PI_NAMEs: YUAN, YAN  (contact)

PROJECT_TERMS: Address;adult stem cell;Affect;AIDS related cancer;angiogenesis;Biological;Biology;Blood Vessels;Cell Differentiation process;Cell Fate Control;Cell Lineage;Cell Reprogramming;cell transformation;Cells;Characteristics;Chromatin;Development;differential expression;Endothelial Cells;Endothelium;Epigenetic Process;epigenetic regulation;Etiology;Event;Evolution;Exhibits;Gene Expression;Gene set enrichment analysis;Genes;Genetic Transcription;Goals;Health;Herpesviridae Infections;histone modification;Human;Human Herpesvirus 8;Hypoxia;Inflammation;Inflammatory Infiltrate;innovation;insight;Kaposi Sarcoma;Lesion;Literature;Lower Extremity;Macrophage;Malignant Neoplasms;Mediating;Mesenchymal;Mesenchymal Differentiation;Mesenchymal Stem Cells;Modeling;Nature;neoplastic cell;novel;Oncogenic;Oncogenic Viruses;Ontology;Oral;Pathologic Neovascularization;Pathway interactions;Phenotype;Play;pluripotent stem cell differentiation;Pluripotent Stem Cells;Prevention;Process;Prognostic Factor;programs;Proliferating;Property;Regulation;Reporting;response;Role;self-renewal;Series;Signal Pathway;Signal Transduction;Skin Tissue;Smooth Muscle;Solid Neoplasm;Spindle Cell Sarcomas;stem cell differentiation;Stimulus;System;therapeutic target;therapeutically effective;therapy resistant;transcriptome;transcriptome sequencing;tumor;tumor microenvironment;tumor progression;tumorigenesis;Vascular Endothelial Growth Factors;vasculogenesis;Viral;Virus

PROJECT_TITLE: Project 2: KSHV induces tumorigenesis by harnessing differentiation in hypoxia


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The OSU Medical Scientist Training Program (MSTP) will train outstanding and driven students in the research and clinical skills needed to position these individuals as the future physician-scientist leaders in the biomedical research workforce. Our program focuses on providing time-efficient instruction that includes key emphasis on rigorous experimental design, ethical conduct in the clinic and the lab, and strong communication skills. By providing state-of-the art medical education with in-depth and technologically advanced graduate training, OSU MSTP graduates will have an optimal skill set to discover fundamental disease mechanisms and use this information to improve human health.

PI_NAMEs: BUMGARDNER, GINNY L;MALLAMPALLI, RAMA K (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TITLE: Medical Scientist Training Program - The Ohio State University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Chronic Pain;Pain Research

ORG_CITY: LUBBOCK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: PROJECT NARRATIVE Post-surgical pain is common amongst those recovering from a surgical procedure. However, a small but significant surgical population experience chronic post-surgical pain. Although it is generally understood that sex hormones contribute to the development and maintenance of pain, including chronic pain, little is known about the role that basal sex hormone alterations play in development and maintenance of chronic post- surgical pain or analgesic post-surgical pain management. The work proposed herein seeks to develop novel altered sex hormone models that mirror the surgical patient population, as well as elucidate antinociceptive profiles.

PI_NAMEs: WILKERSON, JENNY  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Address;Affect;Analgesics;antinociception;Behavior;Behavioral;Chronic;chronic pain;Clinical;Depressed mood;Development;Drug Kinetics;Etiology;experience;Genetic;Genome;genome-wide;Genomics;Goals;Gonadal Steroid Hormones;Gonadal structure;healing;Hormones;Human;improved;in vivo monitoring;Individual;insight;Knowledge;Laboratories;Maintenance;Measures;Modeling;Molecular;Moods;mouse model;Mutation;novel;Operative Surgical Procedures;Pain;Pain management;pain model;patient population;pharmacologic;Play;Population;Positioning Attribute;Postoperative Pain;pre-clinical;preclinical study;Predisposition;Recovery;Rodent Model;Role;Surgical incisions;Tissues;Translating;Vulnerable Populations;Whole Organism;Work

PROJECT_TITLE: Examination of sex hormone alteration on post-operative pain development and treatment

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: BLACKSBURG

ORG_DEPT: NUTRITION

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Project Narrative Type 2 diabetes (T2D) is a growing public health problem in the U.S., which presently affects at least 37 million Americans with an estimated 1.4 million new cases diagnosed very year. It is primarily caused by obesity- associated insulin resistance and dysfunction of insulin producing beta-cells. This research is aimed at identifying and developing safe and low-cost agents that simultaneously promote weight loss and reverse T2D.

PI_NAMEs: LIU, DONGMIN  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acids;Adjuvant Therapy;Affect;American;Animals;Anti-diabetic Drugs;Appetite Depressants;Beta Cell;Biological Availability;blood glucose regulation;Body Weight decreased;Brain;Cell Physiology;Closure by clamp;Combined Modality Therapy;cost;db/db mouse;Desire for food;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diagnosis;diet-induced obesity;Dose;driving force;Drug usage;Eating;effective therapy;Energy Intake;Energy Metabolism;euglycemia;Fatty acid glycerol esters;feeding;food protection;Functional disorder;Gastric Emptying;GLP-I receptor;glucagon-like peptide 1;Glucose;glucose metabolism;glucose uptake;glycemic control;Goals;Grant;Health;Human;Hyperglycemia;Hyperinsulinism;Hypoglycemic Agents;Hypothalamic structure;Immunohistochemistry;In Vitro;in vivo;inhibitor;innovation;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Insulin Signaling Pathway;Intestinal Secretions;Intestines;islet;Knockout Mice;L Cell (Intestine);Life Style Modification;lipid metabolism;Liver;Maintenance;Measures;Mediating;Metabolic;Metabolic Control;metabolic profile;Metabolism;Metformin;Molecular;mouse model;Mus;Natural Products;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obese Mice;Obesity;obesity treatment;Olives - dietary;Oral;Oral Administration;Pathway interactions;Patients;Peptide YY;peptide YY receptor;Peripheral;pharmacologic;Pharmacotherapy;Plant Leaves;Play;preservation;Prevalence;prevent;programs;Public Health;receptor;Receptor Signaling;Research;response;Risk;Role;Safety;Satiation;Skeletal Muscle;small molecule;System;Testing;Time;Tissues;Toxic effect;Transgenic Mice;United States;Virulence Factors;Weight Gain

PROJECT_TITLE: Discovery and characterization of a novel natural product for the treatment of both diabetes and obesity

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Cancer;Genetics;Infectious Diseases;Rare Diseases;Skin Cancer

PHR: Project Narrative MCPyV represents a ubiquitous skin infection that can cause an extremely lethal skin cancer, MCC. In this project, we propose to examine how the MCPyV-host interaction controls hypoxic gene expression during MCPyV infection and MCC tumorigenic progression. Knowledge gained from this study will provide new insights into the oncogenic mechanism of MCPyV, which contributes significantly to HIV/AIDS-associated malignancies.

PI_NAMEs: YOU, JIANXIN  (contact)

PROJECT_TERMS: Affect;AIDS related cancer;angiogenesis;Automobile Driving;Cancer Etiology;carbonate dehydratase;carcinogenesis;Cell Hypoxia;Cell Proliferation;Cells;ChIP-seq;chronic infection;Clustered Regularly Interspaced Short Palindromic Repeats;coping;Data;Death Rate;Dermis;Development;Disseminated Malignant Neoplasm;DNA;DNA Binding;DNA Sequence Alteration;Environment;Epigenetic Process;Gene Expression;Genes;Genetic Transcription;Genome;Hair follicle structure;Human;Hypoxia;Immunosuppression;improved;In Vitro;Incidence;Infectious Skin Diseases;insight;knock-down;Knock-out;Knowledge;laser capture microdissection;lipid nanoparticle;Malignant Neoplasms;Mediating;Merkel cell carcinoma;Merkel Cells;Messenger RNA;Metabolic;metaplastic cell transformation;Modeling;nanoparticle delivery;Neoplasm Metastasis;neoplastic cell;novel strategies;Oncogenes;Oncogenic;Oncogenic Viruses;Organoids;Polyomavirus;Polyomavirus Infections;pressure;prevent;Proliferating;Reader;recruit;response;Risk Factors;siRNA delivery;Skin;Skin Cancer;Small Interfering RNA;spheroids;Subcutaneous Tissue;Testing;Therapeutic Intervention;Transcriptional Regulation;transcriptome;tumor;tumor growth;tumor hypoxia;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;tumorigenic;Up-Regulation;Vascular Endothelial Growth Factors;VEGFA gene;Viral;Viral Genome;Viral Oncogene;Virus;Virus Diseases;Virus Integration;Virus Replication;Xenograft Model

PROJECT_TITLE: Project 3: Skin hypoxia, MCPyV infection, and MCC tumorigenesis


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: Narrative: Epstein-Barr virus (EBV) is responsible for 200,000 new cancers each year. Like other DNA tumor viruses, EBV utilizes cellular oxygen-dependent metabolism and signaling pathways to drive oncogenic transformation. This proposal focuses on understanding how EBV responds to hypoxia and oxidative stress to drive epigenetic changes associated with viral latency and cellular oncogenesis. This study is highly aligned with other projects of this Program Project and will enhance our knowledge and strategies for therapeutic intervention in viral associated cancers.

PI_NAMEs: LIEBERMAN, PAUL M. (contact)

PROJECT_TERMS: 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine;Affect;Automobile Driving;B lymphocyte immortalization;Binding;Burkitt Lymphoma;Carcinoma;Cell Line;Cell Survival;Cells;CpG Island Methylator Phenotype;Data;DNA Methylation;DNA Tumor Viruses;EBNA2 protein;Environment;Enzymes;Epigenetic Process;epigenome;Episome;Epithelium;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Malignant Neoplasm;gammaherpesvirus;Genes;Genetic Transcription;genomic locus;histone modification;Human;Human Herpesvirus 4;Hypoxia;hypoxia inducible factor 1;Immune response;insight;Knowledge;latent infection;Lymphoid;Maintenance;Malignant Neoplasms;Maps;member;Metabolism;normoxia;Nuclear;Nutrient Depletion;Oncogenic;Oncogenic Viruses;Oxidative Stress;Oxygen;Pathway interactions;Play;Primary Infection;Process;Procollagen-Proline Dioxygenase;programs;Proteins;Regulation;response;Role;Signal Pathway;Site;small molecule inhibitor;Testing;Therapeutic Intervention;Tumor Suppressor Genes;tumorigenesis;Viral;Virus;virus episome maintenance;Virus Latency;virus related cancer

PROJECT_TITLE: Project 4: Regulation of EBV Latency and Oncogenesis by Hypoxia


NIH_SPENDING_CATS: Cancer;HIV/AIDS

PHR: Narrative The administrative core will be the managing arm of the program project and will provide oversight of all administrative and scientific components of the four projects and cores. It will be responsible for organization of all meetings between the key personnel and leaders as well as internal and external advisory boards.

PROJECT_TERMS: Advisory Committees;arm;Communication;Dental Schools;Genetic Transcription;Goals;Group Meetings;Human Resources;Hypoxia;Infectious Agent;Institution;Laboratories;Link;Manuscripts;medical schools;Medicine;meetings;Mission;Oncogenic Viruses;posters;Preparation;programs;Progress Reports;Research;Research Personnel;symposium;The Wistar Institute


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Data Science;Emerging Infectious Diseases;Health Services;Infectious Diseases;Lung;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Rare Diseases;Tuberculosis;Women's Health Research

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: PROJECT NARRATIVE New drugs and shortened combination regimens have been introduced for the prevention and treatment drug- susceptible and drug-resistant tuberculosis (TB) but their impact on pregnant people and their infants, including TB transmission and pediatric TB, is uncertain. This partnership between the Centre for Infectious Disease Epidemiology & Research, University of Cape Town and the Western Cape Health Intelligence Directorate will consolidate existing relationships across clinical, epidemiological and data science disciplines to establish a scalable data infrastructure for the management of maternal TB at the regional and individual clinical levels. Data science techniques will be employed to develop and enhance a novel and robust public service population-level data harmonization platform to i) create actionable clinical tools to optimize person-level interventions and monitor programs; ii) generate large, linked cohorts to address epidemiological questions and assess the impact of policy interventions and clinical tools at the population and individual levels.

PI_NAMEs: KALK, EMMA KATE (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;adverse outcome;Affect;Africa;Age;Algorithms;Anemia;antenatal;Antimycobacterial Agents;antiretroviral therapy;Asphyxia;burden of illness;care outcomes;Cause of Death;Cessation of life;child bearing;Childhood;Client;Clinical;Clinical Data;Clinical Management;Clinical Services;clinically actionable;co-infection;Code;cohort;community engagement;comorbidity;dashboard;Data;data centers;data harmonization;data infrastructure;data integration;data platform;Data Science;Diagnosis;Discipline;Disease;Disease Outcome;disease transmission;Drug Combinations;Drug Interactions;drug repurposing;Drug resistance;Drug resistance in tuberculosis;Effectiveness;electronic data;electronic health data;Environment;Epidemic;Epidemiology;Feedback;fluoroquinolone resistance;Fluoroquinolones;Funding;Geography;Gestational Age;Government;Guidelines;Health;health data;Health Information System;health service use;Health Services;high risk;HIV;HIV therapy;HIV/TB;Hospitalization;Human;Incidence;Individual;Infant;Infant Health;infant outcome;Infectious Disease Epidemiology;innovation;Intelligence;Intervention;Laboratories;Lactation;Linezolid;Link;Low Birth Weight Infant;Maternal Health;Maternal Health Services;maternal outcome;Modeling;Monitor;Morbidity - disease rate;mortality;Mothers;novel;novel therapeutics;Outcome;Patients;Pattern;Patterns of Care;Perinatal;perinatal HIV;Perinatal Infection;Persons;Pharmaceutical Preparations;Pharmacy facility;phenotyping algorithm;Policies;Population;Positioning Attribute;Postpartum Period;Pre-Eclampsia;Predisposition;Pregnancy;pregnancy health;Pregnancy Outcome;pregnant;premature;Prevalence;Prevention;Preventive therapy;Process;programs;Prophylactic treatment;Province;Public Health;Public Sector;Regimen;Relative Risks;Reporting;Research;Retreatment;Rifampicin resistance;Risk;Risk Factors;Safety;screening;Services;South Africa;Spontaneous abortion;stillbirth;Techniques;Therapeutic Agents;Therapeutic Intervention;Time;tool;transmission process;Tuberculosis;tuberculosis treatment;United States National Institutes of Health;Universities;Women's mortality;Work

PROJECT_TITLE: INnovative data Science to Impact the TB Epidemic - INSITE

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-L(70)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases

PHR: Narrative: The virus vector and cell culture core will provide a unique resource for the program members that allows streamlined establishments of required reagents using standard operation procedures across all the projects in one core. All vectors, virus preparations and cell cultures will also be standardized, and established for the program members to enhance their research activities and productivity.

PROJECT_TERMS: 3-Dimensional;Adherent Culture;Award;Biological;Cell Culture Techniques;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complementary DNA;conditional knockout;Consultations;Consumption;cost;Databases;Dermal;design;Engineering;experimental study;expression vector;Generations;Genes;Genetic Recombination;Genetic Transcription;Goals;Guide RNA;Herpesviridae;Human Herpesvirus 4;Human Herpesvirus 8;Hypoxia;In Vitro;Individual;Infection;keratinocyte;knock-down;Knock-out;Laboratories;large scale production;Lentivirus;medical schools;member;Methods;Molecular;Mutagenesis;Mutation;Oncogenic Viruses;Online Systems;operation;oral cavity epithelium;Organoids;Preparation;Primary Cell Cultures;Procedures;Production;Productivity;programs;Proteins;Reagent;recombinant virus;Recombinants;repository;Reproducibility;Research Activity;Research Personnel;Resources;Services;Site;small hairpin RNA;Standardization;System;three dimensional cell culture;Time;Transfection;vector;Viral;Virus

PROJECT_TITLE: Virus, Vector and Cell Culture Core


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The goals of the Pittsburgh Center for Kidney Research, a George M. O'Brien Kidney National Resource Center, are to provide critical resources for investigators throughout the US to advance studies of normal and abnormal kidney function and the cellular mechanisms that contribute to these states. To achieve these goals, the center supports an Administrative Core, two Biomedical Research Cores, a Resource Development Core, a Summer Educational Experience Program for undergraduate students and a Lay Education Program.

PI_NAMEs: KLEYMAN, THOMAS R (contact)

PROJECT_TERMS: Acceleration;Address;Animals;Area;autocrine;Biological Models;Biology;Biomedical Research;biomedical resource;Cell Culture Techniques;cell type;Cells;Cellular biology;Collaborations;Communities;Complement;complement resource;Complex;Core Facility;Data;design;Development;Diet;Disease;Education;Educational process of instructing;Endocrine;Ensure;Epithelial Cells;Equilibrium;Equipment;Event;experience;Faculty;Fostering;Friends;Functional disorder;Funding;genetic manipulation;Goals;Grant;Health;Homeostasis;Human;Image;imaging approach;Imaging Device;Imaging Techniques;Individual;innovation;insight;interest;Kidney;Kidney Diseases;kidney dysfunction;kidney imaging;Knowledge;Manuscripts;medical schools;member;Modeling;Molecular;Nephrons;novel;novel strategies;Organ;Organelles;Organoids;paracrine;Pathway interactions;personalized approach;Physiological;Physiology;Positioning Attribute;Productivity;programs;protein function;Protocols documentation;Pump;receptor;Recording of previous events;Regulation;Renal function;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Resolution;Resource Development;Resources;Role;Scientist;Signal Transduction;Speed;Students;Sum;summer student;Talents;tool;Training;Tubular formation;undergraduate student;Universities;Work;Yeasts

PROJECT_TITLE: Pittsburgh Center for Kidney Research


PROJECT_TERMS: Awareness;biomedical resource;Budgets;Cellular biology;Collaborations;Communities;Community Outreach;cooking;Core Facility;Education;Ensure;Evaluation;Expenditure;inorganic phosphate;Kidney;Leadership;Maintenance;Medical center;meetings;Methodology;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;novel;operation;outreach;outreach program;Patient Care;Phase;Physiology;Plants;Potassium;Production;programs;Progress Reports;Quality Control;Renal function;Reporting;Research;Research Personnel;Resource Development;Resources;Role;social media;Sodium;summer student;Universities;Update;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Infectious Diseases

PHR: Narrative: The Next Generation Sequencing core (NGSC) is responsible for all high-throughput sequencing and bioinformatics activities required for DNA, RNA and ChIP-sequencing. All activities including library preparations will be done at the NGSC and will be done closely connected with the ACC NGS Core facility supported by the NCI Abramson Cancer Center.

PROJECT_TERMS: Address;ATAC-seq;Award;Bioinformatics;Biological Assay;Biometry;Cancer Center;Center Core Grants;ChIP-seq;chromatin immunoprecipitation;Complement;Complex;Core Facility;Data;Data Analyses;data management;DNA sequencing;DNA Sequencing Facility;experience;experimental study;follow-up;Genetic Transcription;Genomics;Goals;Herpesviridae;High-Throughput Nucleotide Sequencing;Human Genome;Human Herpesvirus 4;Human Herpesvirus 8;Hypoxia;Leadership;Libraries;Maps;medical schools;member;Methodology;Methods;next generation sequencing;Oncogenic;Oncogenic Viruses;Online Systems;Preparation;Procedures;programs;Protocols documentation;Research Personnel;Sampling;Services;Standardization;success;Technical Expertise;Technology;transcriptome sequencing;Work

PROJECT_TITLE: Next Generation Sequencing Core


PI_NAMEs: SUBRAMANYA, AROHAN R (contact)

PROJECT_TERMS: absorption;Acceleration;Acids;Animal Model;Animals;Applications Grants;base;Bioenergetics;Biological Models;biomedical resource;Blinded;Cardiovascular system;Catalogs;Cell Culture Techniques;cell immortalization;Cell Line;Cell Separation;cell type;Cell Volumes;Cells;Collaborations;Communities;Complex;Computer Models;Creativeness;CRISPR/Cas technology;Data;Data Set;design;Development;Disease;disease model;Distal;Ensure;Environment;Epithelium;Evaluation;Experimental Designs;experimental study;Feedback;Functional disorder;gene conservation;Generations;Genetic study;Genotype;Goals;Grant;hands on instruction;Health;Homeostasis;Hormone Responsive;Human;Individual;induced pluripotent stem cell;Infrastructure;innovation;Instruction;Investigation;Journals;Kidney;kidney cell;Kidney Diseases;Leadership;Liquid substance;Measures;meetings;member;Metabolism;metabolomics;Methods;Mitochondria;Modeling;Monitor;Mus;nephrogenesis;Nephrons;new technology;next generation;Organism;Organoids;Output;Peer Review;Pharmaceutical Preparations;Physiology;Play;Process;Productivity;proteostasis;Protocols documentation;Publications;Purines;Quality Control;Reagent;Recording of previous events;recruit;Renal function;Reproducibility;Research;Research Personnel;Resolution;Resource Development;Resource Sharing;Resources;response to injury;Rodent;Rodent Model;Role;sabbatical;Saccharomyces cerevisiae;Scientist;Services;skills;social media;solute;Specialized Center;System;Technology;Testing;tool;Training;Validation;web site;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Model Systems Core


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Substance Misuse;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

ORG_STATE: CA

PHR: NARRATIVE With successful treatment of human immunodeficiency virus (HIV) infection, many people with HIV are now living a normal lifespan and advancing toward ages when physical and cognitive declines emerge. It is not known, however, whether treated HIV infection carries a liability for accelerated aging and signs of frailty or whether common comorbidities, notably alcohol use disorder (AUD), contribute to further decline. Elucidation of brain alterations associated with cognitive and motor deterioration in people aging with HIV will advance our understanding of underlying pathology and lend insight into prevention and treatment.

PI_NAMEs: PFEFFERBAUM, ADOLF  (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Acceleration;Age;age acceleration;age related decline;Aging;aging related;Alcohol abuse;alcohol use disorder;Algorithmic Analysis;Anisotropy;Attention;Attenuated;Behavior;Blood Pressure;Brain;Brain Stem;brain tissue;Characteristics;Cognition;Cognitive;cognitive ability;Cognitive deficits;comorbidity;Cross-Sectional Studies;Demyelinations;Dentate nucleus;Deposition;Deterioration;Diagnosis;Diagnostic;Diffusion Magnetic Resonance Imaging;Disease;disorder control;Equilibrium;executive function;Exhibits;frailty;functional decline;Gait;Globus Pallidus;gray matter;high body mass index;HIV;HIV Infections;HIV-associated neurocognitive disorder;Image;Impaired cognition;indexing;insight;Iron;Length;life span;Liquid substance;Lobar;longitudinal analysis;Longitudinal Studies;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measures;men;Motor;motor deficit;Movement;Myelin;National Institute on Alcohol Abuse and Alcoholism;neural;neuroimaging;normal aging;novel;Older Population;Participant;Pathology;Persons;Population;Posture;Predisposition;Prevention;Process;programs;Protocols documentation;putamen;Radial;Recovery;Red nucleus structure;response;Short-Term Memory;Standardization;Structure;success;Testing;Tissues;Tremor;Ventricular;verbal;Video Recording;Virus Diseases;visual learning;visual memory;white matter;White Matter Hyperintensity;Woman;Writing

PROJECT_TITLE: Tracking HIV Infection & Alcohol Abuse CNS Comorbidity with Neuroimaging

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project narrative Breast cancers are poorly immunogenic, which significantly hampers breast cancer immunotherapy. The finding that DN T cells can inhibit tripe-negative breast cancer growth is novel and has not been explored. Deciphering the cellular and molecular mechanism of how DN T cells orchestrate antitumor immune response in breast cancer will fundamentally advance our knowledge in tumor immunology and allow us to develop more effective DN T cell-based cancer immunotherapy for breast cancer treatment.

PI_NAMEs: ZHANG, HUI  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Accounting;Advanced Malignant Neoplasm;American;anti-PD-1;anti-tumor immune response;antitumor effect;Antitumor Response;Biology;Breast Cancer Patient;Breast Cancer Treatment;cancer diagnosis;cancer immunotherapy;cancer therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Chemoresistance;chemotherapy;Classification;Clinical;Combination immunotherapy;Complex;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Development;Disease;Donor person;Early treatment;EO771;Epidermal Growth Factor Receptor;ESR1 gene;Exhibits;Family;Foundations;Generations;Goals;Growth;Human;Immune;Immune checkpoint inhibitor;Immune system;immunogenic;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;Infiltration;innovation;Knockout Mice;Knowledge;Lymphoma;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Melanoma;Metastatic breast cancer;Methods;Modeling;Molecular;mouse model;Mucous Membrane;Mus;Natural Killer Cells;Non-Small-Cell Lung Carcinoma;novel;Patients;Play;Population;Pre-Clinical Model;Progesterone Receptors;Regimen;Regulatory T-Lymphocyte;Reporting;Research;Resistance development;response;Role;Shapes;Solid;success;survival outcome;T cell response;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Testing;thymocyte;Tissues;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor-Infiltrating Lymphocytes;Wild Type Mouse;Woman

PROJECT_TITLE: Mechanism of double-negative T cells in antitumor immunity to breast cancer

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


PI_NAMEs: CARATTINO, MARCELO DANIEL (contact)

PROJECT_TERMS: Address;Animal Model;Applications Grants;Area;Biological Assay;Biological Models;Biological Process;biomedical resource;Carrier Proteins;cell immortalization;Cell Line;Cells;Chemicals;Collaborations;Communities;Core Facility;Data;Data Analyses;Data Set;Dedications;Development;Disease;Electrophysiology (science);Ensure;Enzymes;Epithelial Cells;Epithelium;Equipment;Experimental Designs;Generations;Genes;Goals;hands-on learning;Health;Human;Imaging Device;Imaging technology;Institution;Ion Transport;Ions;Journals;Kidney;Laboratories;Light;live cell imaging;Maintenance;Mammals;Measurement;Mediating;Mediator;member;Membrane;Membrane Potentials;Modeling;Molecular;Mus;Nephrons;novel;Organ;Organoids;Oryctolagus cuniculus;Perfusion;Phenotype;Physiological;Physiological Processes;Physiology;Preparation;Productivity;Protein Analysis;protein expression;Proteins;Protocols documentation;Publications;quality assurance;Quality Control;Rattus;Reagent;Regulation;Regulatory Pathway;Renal function;Reproducibility;Research;Research Personnel;Resource Development;Resources;sabbatical;Science;sensor;Series;Signaling Molecule;single molecule;solute;Structure;System;Systems Development;Techniques;Technology;Time;Tissues;tool;Training;Transport Process;Tubular formation;Variant;variant of unknown significance;Work

PROJECT_TITLE: Physiology Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The development of blood-based biomarkers to test for the earliest stages of Alzheimer’s Disease has significant potential to improve care, by allowing affordable, accessible, and non-invasive testing to identify patients at risk for cognitive impairment in primary care. Primary care providers and patients will face new challenges in deciding whether and when to use blood biomarker tests in their patients. This study seeks to understand how decisions about diagnosing cognitive complaints are made, and to use healthcare engineering approaches to design and test a communication intervention to support decisions about blood biomarker testing in primary care.

PI_NAMEs: KETCHUM, FRED  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;age-related disease;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;American;Attitude;Award;Behavior Therapy;behavioral clinical trial;Biological Markers;Blood;Blood Tests;blood-based biomarker;care systems;career;career development;Caring;Characteristics;Clinical;clinical encounter;Cognitive;Communication;Complex;Conduct Clinical Trials;Data;Decision Making;design;Development;Diagnosis;Diagnostic;Disease;Disparity;Doctor of Philosophy;Early Diagnosis;effective intervention;Engineering;Environment;Ethics;ethnic diversity;ethnic minority;ethnic minority population;Evaluation;experience;Face;Focus Groups;follow-up;Future;Goals;Grant;Healthcare;Healthcare Systems;Impaired cognition;improved;Infrastructure;Institution;Intervention;Interview;Medical;Memory;Memory Loss;Mentors;Methods;minority patient;Modification;Neurobehavioral Manifestations;Neurologist;older adult;Outcome;Participant;Pathologic;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Performance;Phase;Pilot Projects;pilot test;Population;Population Heterogeneity;pre-clinical;preference;Primary Care;primary care practice;primary care provider;primary care setting;primary outcome;Process;prodromal Alzheimer's disease;psychosocial outcome;Qualitative Research;racial diversity;racial minority;racial minority population;recruit;Research;research clinical testing;Research Personnel;Risk;Sampling;Science;Scientist;screening;shared decision making;simulation;skills;social;Specialist;Structure;support tools;Surveys;Testing;tool;Training;usability;user centered design;Work

PROJECT_TITLE: Preparing for Blood-Based Alzheimer’s Disease Biomarker Testing in Diverse Populations: Development of a Decision-Support Tool for Primary Care

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Women's Health Research

ORG_CITY: FORT COLLINS

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE This career development award supports the transition to independence for a veterinary scientist with an interest in reproduction/contraception. In this application, our goal is to 1) demonstrate that extracellular vesicles (EVs) display tropism toward their tissue of origin and 2) establish gene editing by EVs loaded with CRISPR-cas9 ribonucleoproteins in vitro and in vivo in a mouse model. The findings of the proposed studies may lead to a novel, non-surgical, permanent contraceptive for women.

PI_NAMEs: THOMPSON, RILEY  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Address;Advisory Committees;Anesthetics;Autopsy;Biodistribution;Body System;Breeding;Cardiovascular system;career development;Cattle;Cell Culture Techniques;Cell secretion;Cells;Clinical;Clinical Trials;Colorado;Contraceptive Agents;Contraceptive Availability;Contraceptive methods;Contraceptive Usage;cost;CRISPR/Cas technology;Data;Deposition;design;Development;Development Plans;Doctor of Philosophy;Electroporation;Embryonic Development;Endometrial;endometrial organoid;Endometrium;Engineering;Epithelial Cells;Exhibits;extracellular vesicles;Fellowship;Fertility;Fertilization;fluorescence imaging;Fluorescent Dyes;Foundations;FVB/N Mouse;Gene Expression;gene-editing approach;Genes;Glycoproteins;Goals;Guide RNA;Hemorrhage;Hormones;Human Resources;Hypersensitivity;imaging system;immune clearance;immunoreaction;In Vitro;in vivo;in vivo Model;Infertility;innovation;intercellular communication;interest;K-Series Research Career Programs;Knock-out;knockout gene;Knowledge;Label;Lipid Bilayers;Lipid Binding;Litter Size;Location;Low income;Mammalian Oviducts;Mammals;Mediating;Membrane Proteins;Mentors;Methods;Microscopy;monolayer;mouse model;Mouse Strains;Mus;neoplastic;neoplastic cell;novel;novel strategies;Nucleic Acids;Operative Surgical Procedures;Organoids;Positioning Attribute;Postdoctoral Fellow;Postpartum Women;preference;Pregnancy;Procedures;Progesterone Receptors;protein expression;Protein Secretion;Proteins;Reaction;Reproduction;reproductive;Reproductive Biology;reproductive tract;Research;Research Personnel;Ribonucleoproteins;Risk;Rodent Model;Scientist;Serum;Sickle Cell Anemia;side effect;skills;Sperm Capacitation;sperm cell;Sterilization;Surface;Surveys;Texas;Therapeutic Trials;tissue fixing;Tissues;Training;Transfection;treatment group;Tropism;tumor;unintended pregnancy;United States;Universities;uptake;Uterus;Viral Vector;Woman

PROJECT_TITLE: Investigating oviductal gene editing delivered via extracellular vesicles as a novel contraceptive


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Kidney Disease;Urologic Diseases

PI_NAMEs: APODACA, GERARD L (contact)

PROJECT_TERMS: 3-Dimensional;4D Imaging;Address;Antibodies;Antigens;Architecture;base;Basic Science;Binding;Biological;Biological Models;Cell Physiology;cell type;Cells;cohort;Collaborations;Collagen;Collection;Computers;cost;Country;Creativeness;Cues;Custom;Dedications;design;Development;Disease;Educational process of instructing;Electron Microscope;Electrons;Energy Transfer;Ensure;Equipment;extracellular;Faculty;Fluorochrome;Freeze Fracturing;Freeze Substitution;Functional disorder;Funding;Goals;Gold;Hand;Image;image processing;Imaging Device;imaging facilities;imaging modality;imaging study;imaging system;Imaging technology;improved;Incubators;Individual;Industry;Infrastructure;Injury;innovation;Kidney;kidney cell;kidney dysfunction;kidney imaging;Label;Light;Location;Lower urinary tract;Maintenance;manufacture;mechanotransduction;Methods;Microfluidics;Microscope;microscopic imaging;Microscopy;Mission;multidisciplinary;novel;Organ;Organelles;Organoids;Performance;petabyte;Physiology;Polarization Microscopy;Positioning Attribute;Protocols documentation;Quality Control;Reagent;Recording of previous events;Renal function;repaired;Research;Research Personnel;Resource Development;Resources;response;Scanning;Schedule;screening;second harmonic;Site;skills;Standardization;Structure;superresolution imaging;System;Technology;technology development;technology platform;Technology Transfer;terabyte;Testing;Three-Dimensional Imaging;Time;Tissues;tool;tool development;Training;Translational Research;transmission process;two-photon;ultra high resolution;Urinary tract;Validation;Variant;Vertebral column;virtual reality;Work

PROJECT_TITLE: Resource Development Core


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Information is believed to be encoded at the cellular level through alterations in synaptic weights, and changes in connections between neurons are correlated with structural modifications of spines, such as growth or elimination. Additional forms of plasticity also impinge on these structures, such as homeostatic modulation of synaptic strength. In this proposal, we will use two-photon imaging and glutamate uncaging to test a variety of plasticity mechanisms at individual spines and between groups of spines, to understand with high precision how information is physically stored in the brain.

PI_NAMEs: ISRAELY, INBAL  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Adult;Affect;Brain;Calcium;Chemosensitization;cognitive function;Complex;Dendritic Spines;Dependence;Development;Electrophysiology (science);Equilibrium;Event;experience;experimental study;Functional disorder;Glutamates;Goals;Growth;hippocampal pyramidal neuron;Hippocampus;Image;in vivo;Individual;information processing;Information Storage;interest;Learning;Logic;Long-Term Depression;Mediating;Mental Depression;Metabotropic Glutamate Receptors;Modification;Molecular;Monitor;neural circuit;Neuronal Dysfunction;Neurons;Outcome;Output;Pattern;Poisson Distribution;Process;Production;Protein Biosynthesis;Proteins;Publishing;Regulation;Resolution;sensor;Shapes;Signal Transduction;Slice;Specificity;Structure;Synapses;synaptic depression;Synaptic plasticity;System;Testing;two-photon;Vertebral column;Weight;Work

PROJECT_TITLE: Understanding how activity drives diverse spine structural interactions

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Debilitating pain, a hallmark of tissue injury and neuropathy, is an unmet clinical challenge in heterotopic ossification (HO) that occurs following orthopedic surgery and traumatic injuries. With an aim at developing new strategies to manage injury-induced chronic pain and pathological HO, we will use novel preclinical models to elucidate the mechanisms downstream of active sensory neuron-specific ACVR1, mechanisms that may be shared by other chronic pain and musculoskeletal injury conditions.

PI_NAMEs: YU, XIAOBING  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: ACVR1 gene;Adult;Afferent Neurons;Axotomy;Biological Assay;bone;bone loss;bone morphogenetic protein receptor type I;Cells;chronic pain;Clinical;Connective Tissue;debilitating pain;effective therapy;gain of function;Genes;Heterotopic Ossification;Histidine;Homeostasis;Hyperactivity;Hypersensitivity;Immune;Immune response;Impairment;In Vitro;in vivo Model;induced pluripotent stem cell;Inflammatory;Inherited;inhibitor;Injury;insight;Intrathecal Injections;kinase inhibitor;Link;Macrophage;Mechanics;Modeling;Molecular;Molecular Target;mouse model;Mus;Muscle;Musculoskeletal Diseases;musculoskeletal injury;nerve injury;Neuroimmune;Neurons;Neuropathy;Neuropeptides;Nociception;Nociceptors;novel;novel strategies;novel therapeutic intervention;Orthopedic Surgery;Osteogenesis;Pain;pain model;painful neuropathy;Pathologic;patient derived induced pluripotent stem cells;Patients;Peripheral;Persistent pain;phase II trial;Physiologic Ossification;Point Mutation;pre-clinical;Pre-Clinical Model;prevent;progressive myositis ossificans;release factor;response;Signal Transduction;Site;small molecule;spared nerve;Spinal Ganglia;Surgical Injuries;Testing;Therapeutic;tissue injury;Tissues;transcriptomic profiling;transcriptomics;Transgenic Mice;Trauma;Traumatic injury

PROJECT_TITLE: ACVR1 sensory neuron-specific signaling in neuropathic pain and injury-induced heterotopic ossification

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ORG_CITY: COLUMBIA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative Sepsis is a global healthcare problem with high incidence and mortality rates, responsible for 20% of deaths worldwide. The goal of this program is to develop an ultra-sensitive, highly selective, and portable solid-state nanopore sensing platform to profile sepsis protein biomarkers in clinical samples and take advantage of a panel of protein markers instead of one specific biomarker as currently done in the clinical setting for rapid and more accurate sepsis early diagnosis and prognosis. Success in this endeavor will be followed by extensive work to construct multi-channel nanopore measurement systems for high-throughput sepsis diagnosis, which should have a broad impact on a variety of areas such as clinical diagnosis, pharmaceutical industry, biosensing, and nanotechnology, offering the potential to lead to remarkable improvement in many facets of human life and society.

PI_NAMEs: GUAN, XIYUN  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: accurate diagnosis;Antibodies;antibody conjugate;antimicrobial;Area;Bacteria;Biological Assay;Biological Markers;biomarker panel;Biosensing Techniques;C-reactive protein;Cause of Death;CD14 gene;Cessation of life;Clinical;clinical diagnosis;cost;Death Rate;Detection;detection limit;Diagnosis;Diagnostic Sensitivity;Diagnostic tests;Diameter;Dimensions;DNA;Dose;Drug Industry;ds-DNA;early detection biomarkers;Early Diagnosis;effectiveness evaluation;Enzyme-Linked Immunosorbent Assay;Functional disorder;global health;Goals;Grant;Healthcare;Hospital Costs;Hospitalization;Human;Immune response;Immunoassay;improved;Incidence;Incubated;Individual;Infection;Interleukin-1;Interleukin-6;Investigation;Ionic Strengths;Length;Life;Lipopolysaccharides;magnetic beads;Measurement;Medicine;Methodology;microbial;Modeling;Molecular Biology;Monitor;Monoclonal Antibodies;multiplex assay;nanoGold;nanopore;Nanotechnology;Organ;Patients;Persons;portability;Preparation;procalcitonin;Prognosis;programs;protein biomarkers;Proteins;Reporter;Resolution;response;Sampling;sensor;Sepsis;septic patients;Septic Shock;Series;Serum;silicon nitride;Single-Stranded DNA;Societies;Sodium Chloride;solid state;specific biomarkers;success;Symptoms;System;Temperature;Thick;Time;TNF gene;tool;Training;United States;voltage;Work

PROJECT_TITLE: Solid-state nanopore detection of protein biomarkers for early sepsisdiagnosis

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: OMAHA

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Cardiac sympathetic overexcitation-related fatal arrhythmia is the most common cause of death in patients with chronic heart failure (CHF). However, concerns about the safety and tolerability of current therapies, such as surgical procedures and medications, are emerging as a limitation to their prescriptions in the clinic. This project will introduce a novel therapeutic strategy using an optogenetic technique to restore CHF-induced cardiac sympathetic overexcitation, and observe whether this strategy reduces cardiac arrhythmia and mortality in animals with CHF, which will provide a novel clinical intervention to avoid the limitation of current therapies and improve prognosis and quality of life in patients with CHF.

PI_NAMEs: LI, YU-LONG  (contact);ZHANG, DONGZE

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Animals;Anti-Arrhythmia Agents;Aorta;Arrhythmia;Attenuated;Blood Vessels;Calcium;Calmodulin;Cardiac;Cause of Death;Cells;Chronic;Clinic;Clinical;Congestive Heart Failure;Conscious;Data;Denervation;Dependovirus;design;excitatory neuron;Ganglia;Genes;Genetic;Granulocyte-Macrophage Colony-Stimulating Factor;Granulocyte-Macrophage Colony-Stimulating Factor Receptors;improved;improved outcome;In Vitro;in vivo;Infection;Inflammatory;Infusion procedures;Interleukin-1 beta;Intervention;Kidney;kidney dysfunction;Light;Link;Macrophage;Macrophage Activation;Measures;Mediating;Mediator;Microglia;miniaturize;Molecular;monocyte;mortality;Nerve;nerve supply;Neuroglia;neuroinflammation;neuronal excitability;Neurons;novel;novel therapeutic intervention;Operative Surgical Procedures;Opsin;optogenetics;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphotransferases;Population;Predisposition;Production;Prognosis;promoter;Quality of life;Rattus;reinnervation;release factor;Renal Artery Stenosis;Reporting;Role;Safety;Serum;Severity of illness;Signal Pathway;Signal Transduction;Specificity;Structure of stellate ganglion;Techniques;Testing;Therapeutic;Tissues;TNF gene;Transfection;Ventricular;Ventricular Arrhythmia;wireless

PROJECT_TITLE: Optogenetic silencing to achieve antiarrhythmic effect of renal denervation in chronic heart failure

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Pasadena

ORG_NAME: ACURASTEM, INC.

PHR: Development of an UNC13A antisense oligonucleotide treatment for ALS and FTD Project Narrative Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are complex diseases that result from many diverse causes. While there are currently no drugs that slow the progression of ALS or FTD, most of the new promising therapeutic strategies are focused narrowly on modifying the specific genetic mutations known to cause disease, however these treatments won’t work for the vast majority (>80% in ALS) of patients for whom the genetic cause of their disease is not known. Therefore, AcuraStem’s focus has been to develop treatments that can work for all ALS and FTD patients, including those for whom the genetic factors driving their disease have yet to be discovered - a large population with urgent unmet need.

PI_NAMEs: CHANG, WEN-HSUAN  (contact);FENG, ZHIHUA

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: Adult;Alleles;ALS patients;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Automobile Driving;Cell Nucleus;Clinic;Clinical;Collaborations;Complex;Cytoplasm;design;Development;Disease;disease model;DNA Sequence Alteration;Dose;Evaluation;Excitatory Synapse;Exons;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;Genetic;genetic approach;genome wide association study;Government;Human;In Vitro;in vivo;Investigational Drugs;Knock-in;Link;Messenger RNA;Mission;Modeling;mouse model;Neuromuscular Junction;Neurons;novel;Pathology;Patients;Persons;Pharmaceutical Preparations;Phase;Play;Population;Positioning Attribute;Probability;protein TDP-43;Proteins;Rattus;Repression;Risk;risk variant;RNA Splicing;Role;Safety;Single Nucleotide Polymorphism;Small Interfering RNA;Spinal Muscular Atrophy;sporadic amyotrophic lateral sclerosis;success;superoxide dismutase 1;Synaptic Transmission;Synaptic Vesicles;The Jackson Laboratory;Therapeutic;Toxic effect;Validation;Variant;vesicular release;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-P(11)B]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: ITHACA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative This project will elucidate the molecular organization and function of proteins that regulate yeast and human genomes. Such organization defines normal and diseased cell states and will help create better diagnostics and treatments for diseases.

PI_NAMEs: PUGH, B FRANKLIN (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 3-Dimensional;Acceleration;Adopted;Architecture;Base Pairing;Binding;Biochemical;Biological Assay;Cell Nucleus;Cells;Chromatin;cofactor;Complex;Diagnostic;Disease;DNA;epigenome;epigenomics;Event;Excision;Gene Cluster;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Goals;Human;Human Genome;human tissue;insight;Knowledge;Life;Location;Maps;Measures;Molecular;Mutation;Persons;Phase;programs;promoter;protein function;protein purification;Proteins;reconstitution;Regulation;Research;Resolution;response;RNA;Saccharomyces;Signal Transduction;Specific qualifier value;System;Technology;Testing;tissue/cell culture;transcription factor;ultra high resolution;whole genome;Yeasts

PROJECT_TITLE: EPIGENOMIC REGULATION OF GENOMES

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE Dysfunction of prefrontal cortex has been implicated a wide array of neuropsychiatric disorders, including obsessive-compulsive disorder, mood disorders, attention-deficit/hyperactivity disorder and addiction. The proposed research on the role the prefrontal cortex in attention and value-based decision will have clear implications for mental health. For example, a better understanding of the representation of cognitive processes in PFC could open the door to more targeted stimulation that uses decoded cognitive states to control the application of stimulation.

PI_NAMEs: MOORE, TIRIN  (contact);WALLIS, JONI D

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: addiction;Algorithms;Anatomy;Animals;Area;Attention;Attention deficit hyperactivity disorder;attentional control;Behavior;Behavior assessment;behavior measurement;behavior prediction;Behavioral;brain machine interface;cell type;Choice Behavior;Clinical;Cognition;Cognitive;cognitive function;cognitive process;Compulsive Behavior;Consensus;covert attention;Decision Making;density;design;Development;Devices;directed attention;electrical microstimulation;Environment;Equilibrium;experimental study;frontal eye fields;Functional disorder;Grant;improved;interest;Interneurons;Lateral;Learning;Link;Location;manufacture;Measurement;Measures;Memory;Mental Health;Methods;microstimulation;Monkeys;Mood Disorders;Motor;neural;neural circuit;Neurons;neurophysiology;neuropsychiatric disorder;neurotransmission;nonhuman primate;novel;Obsessive-Compulsive Disorder;Outcome;Output;Patients;Play;Population;Prefrontal Cortex;Primates;Process;Production;Property;Protocols documentation;public health relevance;Reporting;Research;response;Rewards;Role;selective attention;Sensory;Signal Transduction;Silicon;Sorting;Stimulus;success;Technology;Testing;Time;Work

PROJECT_TITLE: Large-scale recordings in Primate Prefrontal Cortex: Mechanisms of Value and Attention


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention

ORG_CITY: ROCHESTER

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative There is rapidly growing evidence that the health and development of the child and adult can be traced to early environmental influences, but fundamental questions remain about which specific early exposures confer risk and by what mechanisms. We pool three Rochester-based cohort studies and collect a new pregnancy cohort to add to and extend the NIH ECHO program into a second phase. We will institute practices to maximize retention of existing participants, ensure recruitment of diverse new pregnant/preconception participants, implement the ECHO Cohort Protocol with high fidelity, and lead analyses of novel and solution-oriented research that will yield robust recommendations for promoting child health outcomes.

PI_NAMEs: BARRETT, EMILY S;MILLER, RICHARD KERMIT;O'CONNOR, THOMAS G (contact);SCHEIBLE, KRISTIN

PROGRAM_OFFICER_NAME: ZANETTI, KRISTA A

PROJECT_TERMS: 4 year old;Accountability;Address;Adult;Affective Symptoms;Area;Asthma;Award;Chemical Exposure;Child;Child Development;Child Health;Childhood;Clinical;cohort;Cohort Studies;Concentration measurement;Conceptions;Data;Data Element;Development;early life adversity;Endocrine Disruptors;Ensure;Exposure to;fetal;follow-up;Health;immune activation;Immune system;Inflammation;Lead;Link;meetings;Modeling;neurodevelopment;novel;Obesity;Outcome;Participant;participant retention;Pathway interactions;Pediatric cohort;Perinatal;Phase;Placental Biology;postnatal;Pregnancy;pregnant;prenatal;prenatal exposure;programs;Protocols documentation;psychosocial;Public Health;Recommendation;recruit;Research;response;Risk;Science;Shapes;Site;Stress;United States National Institutes of Health

PROJECT_TITLE: Common Mechanisms linking Pre- and Post-Natal Exposures for Child Health Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: LA JOLLA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Overall The UCSD Center Core Grant for Vision Research will provide core services and resources to enhance and accelerate the productivity and impact of vision research at UCSD. These resources will be used to foster collaboration among faculty from the Jacobs School of Engineering, Halicioglu Data Science Institute, Institute for Genomic Medicine, and the Departments of Ophthalmology, Neurosciences, Biomedical Informatics, Pharmacology and Psychology to bring us closer to our goal of the prevention and cure of blinding eye diseases such as glaucoma, macular degeneration and diabetic retinopathy.

PI_NAMEs: ZANGWILL, LINDA M (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Acceleration;Address;Anatomy;Animal Structures;Animals;Award;Basic Science;Biology;biomedical imaging;biomedical informatics;Biometry;Biostatistics Core;California;Center Core Grants;Clinical;Clinical Research;cloud based;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;computer science;Computer software;Computers;computing resources;Core Grant;Data;Data Science;Database Management Systems;Dedications;Dependovirus;Diabetic Retinopathy;dimensional analysis;Drug Screening;Electronic Health Record;Eligibility Determination;Engineering;Ensure;Equipment;Eye;Eye diseases;Faculty;Family;Fostering;Functional Imaging;Funding;Future;Genes;Genomic medicine;Glaucoma;Goals;Health;high dimensionality;histological specimens;Histology;Human;Human Resources;Image;Immunohistochemistry;improved;Individual;Informatics;Infrastructure;Institution;instrumentation;Interdisciplinary Study;Lentivirus Vector;Licensing;Macular degeneration;Microscopy;Names;National Eye Institute;Neurosciences;Ophthalmology;Performance;Pharmacology;Prevention;Process;Production;Productivity;programs;Psychology;Research;Research Personnel;research study;Resource Sharing;Resources;Schools;Scientist;Secure;service organization;Services;structural imaging;Techniques;tissue processing;Tissues;United States National Institutes of Health;Universities;Viral;Vision;Vision research

PROJECT_TITLE: NEI Center Core Grant for Vision Research


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Overall: Project Narrative Frailty is an age-related syndrome of multisystemic decline which confers vulnerability to many other adverse outcomes including loss of independence. This OAIC is designed to foster high quality research which will identify etiologies of frailty and develop clinical and prevention strategies that will improve function, health and independence for millions of older adults.

PI_NAMEs: BANDEEN-ROCHE, KAREN J.;WALSTON, JEREMY D (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Address;adverse outcome;Age;age related;Aging;American;Area;Attention;Basic Science;Biological;biological research;Biological Sciences;Biology;Biomedical Engineering;Biometry;career;Clinical;clinical practice;Clinical Research;Clinical Sciences;clinical translation;Cognition;Cohort Studies;Communities;community intervention;Community of Practice;coping;Data Analytics;Data Science;Dedications;design;Development;diagnostic strategy;Disparity;Education;education research;Engineering;Equity;Etiology;evidence based guidelines;experience;Faculty;Fostering;frailty;functional improvement;Funding;Goals;Grant;Health;health equity;health management;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Intervention;intervention delivery;Knowledge;knowledge translation;Lead;Leadership;Machine Learning;Maintenance;Mentorship;Methodology;Methods;Mission;Modality;mortality;new technology;next generation;novel;older adult;Older Population;outreach;Personal Satisfaction;Policies;Population;population based;prevent;Prevention Guidelines;Prevention strategy;Productivity;Professional Organizations;programs;Publications;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Risk Factors;Running;Scholarship;Science;Scientific Advances and Accomplishments;scientific organization;Services;social media;stressor;Syndrome;Technology;Technology Assessment;technology intervention;therapy development;Training;Training Activity;Training and Education;Translating;Translational Research;Translations;treatment strategy;Universities;Vision;web site;Work

PROJECT_TITLE: Older Americans Independence Center


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: Advisory Committees;Center Core Grants;Core Grant;Ensure;Principal Investigator;Research Activity;Research Personnel;Resources;Services;Vision;Vision research

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Prevention

PI_NAMEs: WALSTON, JEREMY D (contact)

PROJECT_TITLE: Leadership and Administrative Core


PI_NAMEs: JAIN, SONIA  (contact)

PROJECT_TERMS: Award;Basic Science;Biometry;Biostatistics Core;Center Core Grants;Clinical Sciences;Collaborations;Communities;Consultations;Data Analyses;data management;Ensure;Funding;Goals;improved;Mentors;Methodology;Modeling;next generation;Productivity;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resources;Sample Size;Training;Vision;Vision research

PROJECT_TITLE: Vision Biostatistics


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: BARTSCH, DIRK-UWE G (contact)

PROJECT_TERMS: animal care;animal imaging;Animal Model;Animal Structures;Animal Technicians;Animal Testing;Animals;anterior chamber;Center Core Grants;Collaborations;Communities;cost;Dedications;Equipment;experimental study;Eye;Eye diseases;Faculty;human model;Image;imaging approach;Imaging Device;imaging modality;imaging system;Individual;instrumentation;Investigation;investigator training;Length;lens;Measures;ocular imaging;Ocular Physiology;Ophthalmology;Optical Coherence Tomography;Qualifying;Research Personnel;Resources;retinal imaging;Scientist;System;Testing;testing services;Thick;Time;Ultrasonography;Vision;Vision research

PROJECT_TITLE: Animal Structure and Function


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE The Deep South Resource Center for Minority Aging Research (RCMAR) is designed to enhance the size and diversity of the scientific workforce advancing the fields of minority aging and health disparities. We are a research-based, mentoring partnership of four academic institutions working together to recruit investigators from under-represented backgrounds, provide education in aging and health disparities research, guide career development through collaborative mentoring, and sustain progress to successful, independent research careers. The research focus of the Deep South RCMAR is on reducing health disparities between Black/ African American and White older adults in the Deep South.

PI_NAMEs: DURANT, RAEGAN WINSTON (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Academia;Address;Affect;African American;African American population;Aging;Alabama;Area;Audience Research;Behavior;Behavioral;Black race;career;career development;Color;Communities;community engagement;Country;County;Darkness;Data Analyses;Databases;Deep South;deprivation;design;Development;Disadvantaged;Discrimination;Disparity;Economics;Education;education research;educationally disadvantaged;Faculty;Funding;Geography;Goals;Health;Health Disparities Research;health disparity;Healthcare;Healthcare Systems;Historically Black Colleges and Universities;human old age (65+);improve minority health;Individual;Infrastructure;innovation;Institution;interest;Intervention;Knowledge;late life;Leadership;Left;Legal;Measurement;member;Mentors;middle age;Minority;Minority Health Research;minority investigator;Minority Recruitment;Morehouse School of Medicine;Names;older adult;Older Population;Outcome;Pathway interactions;Persons;Pilot Projects;poor health outcome;Positioning Attribute;Poverty;Productivity;Program Effectiveness;programs;psychologic;recruit;Reduce health disparities;Research;Research Design;Research Personnel;Research Project Grants;Resources;Rural;rural setting;Science;Scientific Advances and Accomplishments;Scientist;secondary analysis;segregation;social;Societies;socioeconomic disadvantage;Soil;Stretching;Structural Racism;United States;Universities;urban setting;Work


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Data Science;Eye Disease and Disorders of Vision;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PROJECT_TERMS: Address;Adoption;Age related macular degeneration;Angiography;Animals;Artificial Intelligence;Basic Science;Big Data Methods;biomedical informatics;Center Core Grants;Clinical;Clinical Data;Clinical Informatics;Clinical Research;cloud based;Collaborations;Communities;Computer Analysis;computer program;Computer software;computing resources;Custom;Data;Data Analyses;data management;Data Scientist;Data Set;Database Management Systems;Diabetic Retinopathy;Electronic Health Record;electronic health record system;exome;Eye diseases;genome sequencing;Genomics;Glaucoma;health information technology;Health Insurance Portability and Accountability Act;Healthcare;High Performance Computing;Histopathology;Human;Image Analysis;Imaging Device;improved;informatics tool;Institution;instrument;large datasets;Libraries;Licensing;Machine Learning;Natural Language Processing;Ophthalmology;Optical Coherence Tomography;relational database;Research;Research Personnel;Research Project Grants;research study;Resolution;Resources;retinal imaging;Secure;Services;signal processing;Site;Software Tools;Source;structural imaging;supercomputer;System;tool;Vision;Vision research;web services;whole genome

PROJECT_TITLE: Computational Ophthalmology and Biomedical Informatics


NIH_SPENDING_CATS: Aging;Clinical Research;Prevention

PI_NAMEs: XUE, QIAN-LI  (contact)

PROJECT_TERMS: Address;Aging;American;Area;attributable risk;Basic Science;Biological;Biostatistics Core;Capital;career;Clinical;clinical practice;clinical translation;cohort;Collaborations;Collection;Communities;Complex;Computer Hardware;Computer software;Data;Data Analyses;Data Analytics;data complexity;data infrastructure;data management;Databases;Dedications;design;Development;Disparity;Documentation;education research;Effectiveness;empowerment;endophenotype;Engineering;Ensure;Etiology;experience;faculty mentor;faculty support;frailty;Funding;Genomics;Gerontology;Goals;Health;Health Promotion;high dimensionality;Housing;Informatics;Infrastructure;innovation;Institution;Intervention;Knowledge;Leadership;Life;Life Cycle Stages;Measurement;Measures;Mentors;Mentorship;Methodology;Methods;middle age;Modernization;molecular marker;new technology;next generation;older adult;Older Population;Online Systems;Outcome;Pattern Recognition;Phenotype;Physiological;pilot test;Population Attributable Risks;Populations at Risk;prevent;Prevention strategy;Property;Public Health Practice;Registries;Reproducibility of Results;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Risk Factors;Role;Scholarship;Science;Scientist;Secure;Signal Transduction;Site;sound;Specificity;Statistical Data Interpretation;statistics;success;Syndrome;synergism;System;Technology;Technology Assessment;tool;Training;Translating;Translational Research;translational study;Translations;web site;Work

PROJECT_TITLE: Biostatistics Core - RC1


PI_NAMEs: AYYAGARI, RADHA  (contact)

PROJECT_TERMS: Animals;Center Core Grants;confocal imaging;Cryoultramicrotomy;Custom;Dedications;Disease;Drug Screening;Electron Microscopy;Equipment;Evaluation;experience;Eye;Eye diseases;Functional disorder;Genetic Engineering;Histologic;histological specimens;Histology;Image;Immunohistochemistry;interest;Location;microscopic imaging;Microscopy;Modeling;Paraffin;pharmacologic;Preparation;Research Personnel;sample fixation;Sampling;Sampling Studies;Services;Slide;Stains;Techniques;Time;tissue processing;Tissues;Vision;Vision research

PROJECT_TITLE: Histology, Tissue Processing and High Content Microscopy


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE: Algorithms continue to proliferate in the health care system, often with dire consequences for marginalized groups. This research proposes building a framework for evaluating the social impact of algorithms in health care before they are deployed to avoid such harms using mathematical decision science modeling. Developing this open-source framework will have the potential for broad impact in reducing health care disparities with a flexible design to allow adaptation to many health settings.

PI_NAMEs: ROSE, SHERRI  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Algorithms;artificial intelligence algorithm;cohort;Communities;Complex;cost;Data Collection;Data Sources;decision making algorithm;design;Development;Disabled Persons;ethnic minority;Feedback;flexibility;Guidelines;Health;health care availability;health care disparity;health economics;Health Policy;Healthcare;Healthcare Systems;Individual;Intervention;Investigation;Machine Learning;marginalized population;Mathematics;Modeling;models and simulation;network models;novel;older adult;open source;Output;Policies;Policy Research;prevent;primary outcome;Principal Investigator;Printing;Proliferating;Public Health;Qualitative Research;racial minority;Research;responsible artificial intelligence;Science;Social Impacts;Source Code;statistics;tool;Work

PROJECT_TITLE: A Framework for the Social Impact of Algorithms in Health Care


PI_NAMEs: ABADIR, PETER M. (contact)

PROJECT_TERMS: age related;age related decline;Aging;aging mechanism;aging related;American;Angiotensins;Animal Model;animal model development;Animals;aptamer;Area;Attenuated;Biological;Biological Aging;Biological Assay;biological systems;Biology of Aging;Biomedical Engineering;Chronic;Clinical;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Communication;Complex;Data;Data Analyses;Development;Diagnostic;diagnostic development;Energy Metabolism;Epigenetic Process;Etiology;experience;Faculty;Fostering;frailty;functional decline;Genetic;Genomics;Gerontology;Goals;healthspan;Human;human subject;Inflammation;Inflammatory;Infrastructure;insight;Institution;International;Intervention;Laboratories;late life;Leadership;Measurement;Measures;Mentors;Mentorship;metabolomics;mild cognitive impairment;Mitochondria;Modality;model development;Molecular;molecular array;mouse model;multiple omics;Nanotechnology;new technology;next generation;novel;older adult;Pathway interactions;Phenotype;Physiological;Physiology;Population Study;prevent;Prevention;Prevention strategy;Preventive;Proteomics;Psychological Transfer;Research;Research Design;Research Personnel;Resources;Sampling;sarcopenia;Science;skills;System;Technology;Technology Transfer;Testing;Therapeutic;therapy development;Tissue Model;Tissues;tool;Training;Translational Research;Translations;Vendor

PROJECT_TITLE: Biological Mechanisms Core - RC2


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

PI_NAMEs: WELSBIE, DEREK STUART (contact)

PROJECT_TERMS: adeno-associated viral vector;Age related macular degeneration;Base Pairing;Cell Culture Techniques;Cells;Center Core Grants;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complementary DNA;cost;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Culture Setup;Dedications;Dependovirus;Development;digital;Disease;disease model;Engineering;Equipment;Eye;Eye diseases;Faculty;fast protein liquid chromatography;functional genomics;gain of function;gene function;Genes;Genetic;Genome;Genome engineering;Glaucoma;Guide RNA;Human Genetics;Human Resources;in vivo;inherited retinal degeneration;Investments;Lentivirus;Lentivirus Vector;loss of function;Mediating;Mutagenesis;novel;Production;Proteins;Reagent;Regulatory Element;repaired;RNA Sequences;Rodent Model;screening;Services;Suspensions;System;Technology;Therapeutic;Time;tool;Transcription Coactivator;Transcription Repressor;vector;Viral;viral gene delivery;Vision research;Writing

PROJECT_TITLE: Viral Production and CRISPR Engineering