NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE One of the major manifestations of the obesity epidemic sweeping the world is the increasing prevalence of non- alcoholic fatty liver disease (NAFLD). This is associated with a loss of the normal hormonal regulation of metabolism and accumulation of fat, and one underlying cause of this is disruption of intracellular signaling pathways that involve dynamic changes of cytosolic calcium. The purpose of this study is to elucidate the early changes in calcium signaling in response to high fat diet, which may precipitate the maladaptations in the hormonal regulation of hepatic metabolism that result in liver disease, diabetes and related comorbidities.

PI_NAMEs: BARTLETT, PAULA  (contact);THOMAS, ANDREW P

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acetyl-CoA Carboxylase;Address;Adipose tissue;Affect;Attenuated;Automobile Driving;Calcium;Calcium Signaling;carbohydrate metabolism;Catecholamines;Cell Respiration;Cell surface;comorbidity;Data;Development;Diabetes Mellitus;Diet;diet-induced obesity;Diglycerides;Enzymes;Equilibrium;euglycemia;Fatty acid glycerol esters;fatty acid oxidation;Fatty Liver;fatty liver disease;Feedback;feeding;Functional disorder;G-Protein-Coupled Receptors;Generations;Glucagon;Gluconeogenesis;glucose output;glycogenolysis;Hepatic;Hepatic lobule;Hepatocyte;High Fat Diet;hormone regulation;Hormones;Impairment;in vivo;Individual;inorganic phosphate;Inositol;Insulin;Insulin Resistance;intravital imaging;knock-down;Lesion;Link;Lipase;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;Liver;liver development;Liver diseases;liver metabolism;Lobular;Lobule;Mediating;Metabolism;Mitochondria;mitochondrial metabolism;Molecular;Molecular Target;mouse model;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Norepinephrine;novel;Obesity Epidemic;oxidation;Pathogenesis;Pathway interactions;Peptide Initiation Factors;Perfusion;Phase;Phospholipase C;Play;Prevalence;Prevention;Protein Isoforms;Protein Kinase C;Regulation;Research Personnel;Resistance;response;Role;Second Messenger Systems;segregation;Signal Pathway;Signal Transduction;Site;Stains;Stratification;synergism;Techniques;Testing;therapeutic target;tool;Triglycerides;Up-Regulation;uptake;Work

PROJECT_TITLE: Dysregulation of calcium signaling in the initiation of fatty liver disease

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative/Relevance Environmental carcinogens that damage DNA promote cancer and so our cells have multiple DNA repair pathways. Importantly, each repair pathway does not operate independently, and so we propose to study how interactions among different DNA repair activities shape the biological consequences of exposure to DNA damage in animal models. The results of this work will give rise to a deeper understanding of how cells react to DNA damage caused by an environmental carcinogen, and this will pave the way toward better ways to predict and prevent cancer.

PI_NAMEs: ENGELWARD, BEVIN P. (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: 3-Dimensional;Address;Agreement;Algorithmic Analysis;Alkylating Agents;Animal Model;Apoptosis;base;Binding;Biological;cancer cell;Cancer Etiology;carcinogenesis;carcinogenicity;Carcinogens;Cell Cycle Arrest;Cell division;Cell Lineage;cell transformation;Cells;Clinic;Clonal Expansion;Data;Dependence;Dimethylnitrosamine;Disease;DNA;DNA Damage;DNA lesion;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA replication fork;Environment;Environmental Carcinogens;Event;Evolution;Exposure to;Food;Frequencies;Futile Cycling;gene environment interaction;Gene Expression;Gene Expression Profile;Genetically Engineered Mouse;Genome;Guanine;Health;Hepatotoxicity;Heritability;homologous recombination;Human;Image;Image Analysis;In Situ;in vivo;Induced Mutation;Inflammation;interest;International Agency for Research on Cancer;Learning;Lesion;Literature;Liver;liver inflammation;machine learning algorithm;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Metabolic;methyl group;Methylation;MGMT gene;Mismatch Repair;Modeling;Molecular;Monitor;Mus;mutant;Mutation;N-nitrosodimethylamine;Normal tissue morphology;novel;Nucleotides;Organ;Pathway interactions;peer;Persons;Pharmaceutical Preparations;Phenotype;Physiological;Predisposition;pressure;Prevalence;prevent;Probability;Process;Proteins;Public Health;Reaction;recombinational repair;repair model;repaired;Resolution;response;Risk;Risk Factors;Role;Shapes;Signal Transduction;Structure;Study models;Technology;Testing;Three-Dimensional Imaging;Thymine;Tissues;Toxic effect;trait;transcriptomics;two photon microscopy;two-photon;Visualization;Water;Work

PROJECT_TITLE: Impact of DNA Repair Pathway Interactions on the Molecular and Physiological Consequences of Methylation Damage

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Building on my early track record of successful mentorship of patient-oriented junior investigators, this K24 will allow me to develop skills in patient-oriented research focused on advanced pharmacometric modeling and real-world data use, and apply them to an expanded rigorous mentoring and training plan for diverse trainees.

PI_NAMEs: HORNIK, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 1 year old;Address;Adult;Affect;Area;Attention;Award;Biometry;Cardiac;Cardiovascular Agents;Cardiovascular Diseases;cardiovascular pharmacology;Cardiovascular system;career;career development;Cessation of life;Child;Childhood;Clinical Drug Development;Clinical Pharmacology;Clinical Research;Clinical Trials;Collaborations;congenital heart abnormality;Coupled;Critical Care;Dangerousness;Data;Data Analyses;data infrastructure;Data Sources;design;Development;Disease Outcome;Doctor of Philosophy;Dose;drug development;drug disposition;Drug Exposure;Drug Kinetics;Drug Labeling;early phase clinical trial;early phase trial;early-career faculty;Education;Educational process of instructing;Electronic Health Record;Enrollment;Ensure;Environment;expectation;experience;Exposure to;Extramural Activities;Faculty;Foundations;Funding;Generations;Health Sciences;improved;Infant;innovation;Institution;Intensive Care Units;investigator training;Joints;Label;Leadership;Letters;Longevity;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methods;mid-career faculty;Modeling;models and simulation;Modernization;Morality;National Institute of Child Health and Human Development;next generation;North Carolina;novel;off-label drug;Outcome;Pathologic;Pathway interactions;patient oriented;patient oriented research;Pediatric cardiology;pediatric drug development;pediatric patients;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology;pharmacometrics;Phase;point of care;Population;Positioning Attribute;Principal Investigator;professor;programs;Protocols documentation;Public Health;Publications;recruit;Reporting;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;response;Role;Science;Scientist;Secure;skill acquisition;skills;success;summer program;Techniques;Therapeutic;Time;tool development;Training;Training and Education;training opportunity;Training Programs;Translating;Translations;undergraduate student;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Mentoring in Pediatric Cardiovascular Pharmacology and Early Phase Trials

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Temporal lobe epilepsy (TLE) is a debilitating disorder that includes chronic seizures and severe cognitive deficits that greatly impair quality of life. There is substantial evidence that the synchronization of brain activity is disrupted in epilepsy but it remains unclear how these changes directly impact seizures and cognitive deficits. This proposal uses a novel system to control the timing of interneurons in epileptic and control mice and will determine how the timing of interneuron firing mediates seizures and cognitive deficits in epilepsy.

PI_NAMEs: SHUMAN, TRISTAN  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acute;Address;Animals;Automobile Driving;Behavior;Brain;Chronic;Cognition;cognitive control;Cognitive deficits;cognitive performance;Control Animal;Data;dentate gyrus;Disease;Epilepsy;Equilibrium;experimental study;Gene Expression;Head;Hippocampus;Impact Seizures;Impaired cognition;Impairment;improved;Individual;information processing;Injections;innovation;insight;Interneurons;Kainic Acid;Measures;Mediating;Mediator;Memory impairment;mouse model;Mus;neural;Neurons;novel;optogenetics;Parvalbumins;Pattern;Performance;Phase;Phenotype;Pilocarpine;Play;Predisposition;Process;Quality of life;Rodent Model;Role;Seizures;Somatostatin;System;Temporal Lobe Epilepsy;Testing;Work

PROJECT_TITLE: Closed-loop Control of Interneuron Spike Timing in Epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project narrative Primary ciliary dyskinesia (PCD) is a genetic disease caused by the failure of cilia to beat, leading to recurrent infections and chronic lung disease, for which there is no treatment. Our proposed project will investigate the role of a novel cilia candidate protein that may provide protective function for motile cilia. We will determine the function of candidate proteins and how cells handle external and internal stress to identify shared pathways that could be therapeutically manipulated to treat PCD.

PI_NAMEs: HORANI, AMJAD  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Airway Disease;airway inflammation;Antioxidants;Apical;Award;Binding;Biology;Bronchiectasis;burden of illness;catalase;Cell Differentiation process;Cell Physiology;Cells;Cellular biology;Cellular Stress;Chronic;Chronic lung disease;Cilia;cilium biogenesis;Cilium Microtubule;cilium motility;Clinic;Code;cytokine;Cytoplasm;Data;Dedications;Disease;Dynein ATPase;Endogenous Factors;Environment;Environmental Impact;Enzymes;Exogenous Factors;Failure;Gene Expression;Generations;Genes;Genetic;Genetic Diseases;Genetic Transcription;Glutathione;Glutathione S-Transferase;GSTA1 gene;Health;Homeostasis;Human;Impairment;In Vitro;in vivo;Individual;infancy;Infection;Interleukins;Knowledge;Link;Lung;Lung Diseases;Measures;Membrane;Microscopy;Modeling;Molecular;Motility;Motor;Motor Activity;mouse model;mutant;Mutation;Neonatal Respiratory Distress;new therapeutic target;Nose;novel;novel therapeutic intervention;Organelles;Oxidants;oxidative damage;Oxidative Stress;Pathogenesis;Pathologic;Pathway interactions;Patients;Play;Primary Ciliary Dyskinesias;programs;Proteins;Proteomics;Reactive Oxygen Species;recurrent infection;Regulation;Respiratory Failure;response;Role;single-cell RNA sequencing;Site;Stress;stress state;Structural Protein;Surface;Syndrome;System;Testing;Therapeutic;Tissue-Specific Gene Expression;Toxin;transcriptomics;treatment response;Variant;Work

PROJECT_TITLE: NRF2 activation program in normal and immotile cilia

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Black/African Americans have a higher risk of developing and dying from lung cancer than non-Hispanic Whites. African Americans also have considerable exposure to major stressors resulting from structural racism, including air pollution and residential segregation. Determining how these stressors affect the development and progression of lung cancer will help identify the mechanisms underlying lung cancer disparities and develop approaches to reduce the high burden of disease in this population with the highest NSCLC risk and mortality.

PI_NAMEs: ERHUNMWUNSEE, LORETTA  (contact)

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: Address;Affect;African American;African American population;Air Pollution;Appearance;Biological;Biological Markers;Biology;Black race;burden of illness;California;Cancer Biology;Cancer Etiology;cancer health disparity;Cancer Patient;cancer recurrence;cancer risk;carcinogenesis;Censuses;Characteristics;Clinical;cohort;Communities;Confidence Intervals;Data;Death Rate;deprivation;Development;Disease;Disease Progression;Disparity;driver mutation;early detection biomarkers;Education;Etiology;Event;Evolution;exome sequencing;experience;Exposure to;fine particles;genetic evolution;genome sequencing;genomic data;Genomics;Goals;Guidelines;Health;health equity;high risk;Housing;improved;Incidence;Income;indexing;Individual;Inflammation;innovation;interest;Intervention;Investigation;KRAS2 gene;Link;Lung;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;marginalized community;Measurable;Measures;Molecular;mortality;Mutation;Mutation Detection;Neighborhoods;neoplasm registry;never smoker;never smoking;Nitrogen Oxides;Non-Small-Cell Lung Carcinoma;Not Hispanic or Latino;novel;Odds Ratio;Operative Surgical Procedures;Outcome;Pathologic Mutagenesis;Pathway interactions;patient stratification;Patients;Pattern;Pollution;Population;prevent;Process;Prognosis;prognostic indicator;racial disparity;racism;Recurrence;Reduce health disparities;Reporting;Resected;residential segregation;risk stratification;Role;Schools;segregation;Smoke;Smoking;Smoking History;social;Social Environment;Social Sciences;socioenvironmental factor;Source;Specimen;stressor;Structural Racism;Supermarket;Surveys;survival disparity;Survival Rate;Techniques;The Cancer Genome Atlas;Time;Tissues;TP53 gene;trend;tumor;Tumor Biology;Tumor Tissue;Vulnerable Populations;whole genome;Work

PROJECT_TITLE: Examining the Impact of Structural Racism on African American Non-Small Cell Lung Cancer Mutational Signatures and Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-9 (J2)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Lung;Patient Safety;Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: PROJECT NARRATIVE Children with acute respiratory distress syndrome (ARDS), a form of severe lung injury, have a high risk of death (20%) and there are no known beneficial medications to lower this risk. We will test whether measuring dead space, a marker of abnormal lung function, may improve our ability to identify which children are at highest risk of dying from ARDS and the children that may benefit from a medication to improve lung function (inhaled Nitric Oxide). The results of this research could have a major impact on designing clinical trials to identify therapies that may decrease the risk of mortality in ARDS.

PI_NAMEs: BHALLA, ANOOPINDAR  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Accounting;Acute Respiratory Distress Syndrome;Address;Adult;Age;Alveolar;Alveolus;Angiopoietin-2;Anti-Inflammatory Agents;Anticoagulation;Area;Biological;biological heterogeneity;Biological Markers;Blood gas;Capnography;Child;Childhood;Clinical Markers;Clinical Trials;Clinical Trials Design;clinically relevant;cohort;comorbidity;cost;Data;effective therapy;Enrollment;experience;Extracorporeal Membrane Oxygenation;Future;Gases;glycation;Heterogeneity;high risk;Hypoxemia;improved;indexing;Individual Differences;Inflammatory;inhaled nitric oxide;Intervention;Kidney Failure;Length;Low Cardiac Output;Lung;lung injury;Measures;Meta-Analysis;Methods;Microvascular Dysfunction;Modeling;Morbidity - disease rate;mortality;mortality risk;National Heart, Lung, and Blood Institute;observational cohort study;Observational Study;off-label use;Organ failure;Patient Monitoring;Patient Selection;Patients;Pediatric Acute Lung Injury;Pediatric Acute Respiratory Distress Syndrome;Perfusion;Pharmaceutical Preparations;pharmacologic;Phenotype;Plasma;Plasminogen Activator Inhibitor 1;Production;prognostic;prospective;pulmonary function;receptor;Refractory;Research;Research Personnel;response;Risk;Risk Marker;risk stratification;secondary outcome;Sepsis;Severities;Severity of illness;Shunt Device;Site;Subgroup;Survivors;Testing;Thrombomodulin;Tidal Volume;Time;treatment effect;treatment response;Vasodilator Agents;ventilation;Ventilator;von Willebrand Factor

PROJECT_TITLE: Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Tinnitus, phantom sound perception, is a common problem that leads to neural changes within primary auditory cortex. Utilizing an innovative fNIRs probe that we adapted to the ear canal from a previous R21 grant, we are now capable of localizing brain changes (possible tinnitus corelates; hemodynamic responses and resting state functional connectivity) in human tinnitus that is both subjective and somatic (modulated by head and neck maneuvers). Our current proposal will fill a vital need in the field, as we will be able to closely measure both types of tinnitus in humans as well as corelate those changes with severity levels in those who can and cannot modulate perception with head and neck movements.

PI_NAMEs: BASURA, GREGORY JOSEPH (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: absorption;Age;Algorithms;analog;Animal Model;Animals;Auditory;Auditory area;auditory pathway;Auditory Perception;Brain;Brain imaging;Brain Stem;Clinical;Clinical Treatment;Coupled;Data;design;Devices;Diagnostic;diagnostic accuracy;Disease;Engineering;Etiology;Exhibits;External auditory canal;functional near infrared spectroscopy;Funding;Goals;Grant;Head and neck structure;hearing impairment;hemodynamics;Hemoglobin;Human;human subject;indexing;innovation;jaw movement;Knowledge;Light;Loudness;Machine Learning;machine learning algorithm;Maintenance;Maps;Measurable;Measures;Movement;neural;neural correlate;Participant;Pathology;Patients;Pattern;Perception;personalized medicine;prediction algorithm;predictive modeling;Prevalence;prognostic;Property;Publishing;Questionnaires;Reporting;Research;response;Rest;Scalp structure;Sensitivity and Specificity;Severities;somatosensory;sound;Standardization;Subjective Tinnitus;Tinnitus;tool;transmission process;Trigeminal System;Variant;Visual

PROJECT_TITLE: Subjective and Somatic Tinnitus; Using Functional Near-Infrared-Spectroscopy to Identify Objective Correlates in Auditory and Non-Auditory Cortices

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE  DNA repair and DNA replication are of critical importance for the maintenance of the genetic information across generations. Mistakes made during these processes can lead to severe diseases, including cancer and developmental disorders. This project will investigate the molecular mechanism of a family of protein complexes, called clamp loaders, that are critical for DNA repair and replication in all eukaryotes.

PI_NAMEs: HITE, RICHARD KEVIN;REMUS, DIRK  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Binding;Biochemical;Cell division;Cell Physiology;Cells;Cellular Stress;Chromatin Modeling;chromosome replication;Chromosomes;Client;Closure by clamp;Complex;Cryoelectron Microscopy;Data;Detection;developmental disease;Disease;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair;DNA replication fork;ds-DNA;environmental agent;Eukaryota;Eukaryotic Cell;experimental study;Generations;genetic information;Genome;genome integrity;Genome Stability;Genomic Instability;Health;Homeostasis;Human;Hydrolysis;Impairment;innovation;insight;Investigation;Knowledge;Laboratories;Maintenance;Malignant Neoplasms;Mediating;Modeling;Molecular;Molecular Conformation;Mutation;novel;Nuclear;Orthologous Gene;Pathway interactions;premature;prevent;Process;protein complex;Protein Family;Proteins;Reaction;reconstitution;repaired;Research;Resolution;response;Role;Saccharomyces cerevisiae;Saccharomycetales;Sampling;Signal Transduction;Site;Slide;Source;Structure;Substrate Specificity;System;Testing;Visualization;Work;Yeasts

PROJECT_TITLE: Structural basis of eukaryotic clamp loading

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE We found that mechanical modulation of cardiac adeno-associated virus (AAV) gene delivery resulted in up to 500-fold improvement in gene expression compared to traditional method. In this proposal, we aim to refine the method, understand the mechanisms and demonstrate safety and efficacy for its clinically relevant application.

PI_NAMEs: ISHIKAWA, KIYOTAKE  (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Acute;adenovirus mediated delivery;Animals;Area;Behavior;Biological;Biological Factors;Blood;Blood capillaries;Blood Vessels;Cardiac;Catheters;Chronic;Clinic;Clinical;clinical application;Clinical Pathways;clinical practice;clinical translation;Clinical Trials;clinically relevant;Coronary;Coronary artery;coronary artery occlusion;Coronary sinus structure;Data;Dependovirus;Devices;Disease;Dose;Endocytosis Inhibition;Endothelium;Ensure;extracellular vesicles;Family suidae;Gene Delivery;Gene Expression;gene therapy;Genes;Heart;Heart failure;heart function;Heart-Assist Devices;hemodynamics;high risk;Human;improved;In Vitro;inhibiting antibody;Injections;innovation;interest;Intervention;Ischemia;ischemic cardiomyopathy;Mechanics;Mediating;Methods;minimally invasive;Modeling;Modification;Myocardial Ischemia;Myocardium;neutralizing antibody;novel;novel therapeutic intervention;Pathologic;patient population;Patients;Pattern;Permeability;Pharmaceutical Preparations;Play;pressure;Prochlorperazine;Protocols documentation;rational design;Refractory;RNA;Rodent;Role;Safety;Serotyping;success;Testing;Time;Tissues;Transduction Gene;translational potential;Treatment Failure;Tropism;Ubiquitin;uptake;Vascular Permeabilities;vector;vector control;Veins;viral detection

PROJECT_TITLE: Cardiac AAV gene delivery for clinical translation

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE For many with substance use disorder, motivation for drug is not appropriately blunted by frustration, meaning that recoupling frustration with decreased motivation is a novel therapeutic strategy. We have developed a method of quantifying frustration-related behavior in rats during operant responding which now allows us to study frustration effects on motivation in real time. This project will determine adolescent factors contributing to individual differences in frustration behavior and identify how frustration-related neurocircuitry couples to decreased cocaine motivation.

PI_NAMEs: GREEN, THOMAS ARTHUR (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Adolescence;Adolescent;Affect;Amygdaloid structure;Attenuated;Basic Science;Behavior;behavior test;behavioral economics;Biology;Chronic;Cocaine;combinatorial;Couples;Coupling;Data;Development;drug testing;economic evaluation;Elasticity;Electrophysiology (science);Emotions;environmental enrichment for laboratory animals;Exposure to;Fentanyl;Foundations;Frustration;Future;genetic approach;genetic manipulation;Goals;Grant;human data;in vivo;Individual Differences;Intake;Life;Life Experience;Measures;Mediating;Methods;Monitor;Motivation;neural circuit;Neurobiology;Neurons;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Nucleus Accumbens;Output;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phenotype;Play;Predisposition;Rattus;resilience;resilience factor;response;Rewards;Risk;Role;Schedule;Stress;Substance Use Disorder;Testing;Therapeutic;therapeutic development;Time;Viral Vector

PROJECT_TITLE: Frustration effects on drug taking

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative: Human Leukocyte Antigen (HLA) matching between a donor and recipient increases kidney graft survival, yet prioritizing antigen-level HLA matching in the kidney allocation system has resulted in racial disparities, with Black recipients getting fewer well-matched organs. Emerging molecular-level mismatch technologies will give us greater precision in identifying which transplants are truly well-matched. We will use computational tools to design an improved allocation system that prioritizes molecular-level instead of antigen-level matching to improve graft longevity, while adjusting allocation scores using a novel personalized metric of the likelihood of finding a well-matched donor, the personalized immunologic compatibility likelihood (PICL) to achieve equity.

PI_NAMEs: GRAGERT, LOREN ;MANKOWSKI, MICHAL A (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: access disparities;Address;Age;Algorithms;antibody-mediated rejection;Antigens;Biological;Biological Markers;Black race;Categories;cell registry;computerized tools;Data;Data Set;design;Disadvantaged;Disparity population;disparity reduction;donor stem cell;donor-specific antibody;Engineering;Equilibrium;Equity;Ethnic Origin;Ethnic Population;experience;Gender;Genetic;Genotype;Graft Survival;Health;high risk;Histocompatibility Testing;HLA Antigens;Hospitals;Immunologics;improved;Inequity;innovation;Kidney;Kidney Transplantation;Life;Longevity;Measures;Medicine;Modeling;Molecular;molecular modeling;novel;Organ;organ allocation;Organ Transplantation;outcome disparities;Play;Policies;Probability;Race;racial disparity;racial population;Recommendation;Reporting;Resolution;Risk;risk stratification;Role;simulation;stem cells;survival disparity;System;Technology;Testing;tool;Transplantation;United States National Academy of Sciences;Wait Time;Waiting Lists

PROJECT_TITLE: Increasing Equity and Utility in Deceased Donor Kidney Allocation with HLA Molecular Matching

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Narrative We discovered and characterized an important role for glia in Rett syndrome (RTT), and the ability of glia, specifically astrocytes, to rescue RTT-like phenotypes in mouse models. Using human-based models for RTT, our recent studies suggest that mitochondrial abnormalities likely mediate the impaired energy metabolism in RTT astrocytes. The proposed studies aim to understand the cause of mitochondrial dysfunction in human astrocytes, the consequences of abnormal mitochondria on astrocytes’ structure and function, and ultimately on their support to neurons. We will rescue the mitochondrial aberrations in human RTT astrocytes and determine whether they, in turn, can rescue the structural and functional aberrations of human RTT astrocytes. The proposed studies have the potential (i) to advance our understanding of impaired mitochondria in human astrocytes and its contribution to RTT neuropathology, and (ii) to identify potential targets to rescuing mitochondrial aberrations and restoring the astrocytes’ support to neurons in human RTT models and, ultimately, in patients.

PI_NAMEs: BALLAS, NURIT  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Acceleration;Affect;Astrocytes;Biological;Biological Assay;Brain;Cell Aging;cell type;Characteristics;Chromatin;Citric Acid Cycle;Cleavage Under Targets and Release Using Nuclease;Data;Defect;Development;differential expression;Disease;Energy Metabolism;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;Glutamates;Heart;Homeostasis;Human;human stem cells;Hypoxia;Impairment;induced pluripotent stem cell;inhibitor;Knowledge;Link;Mediating;Metabolic;Methyl-CpG-Binding Protein 2;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular;Morphology;mouse model;Mus;mutant;Mutation;Nervous System Disorder;Nervous System Physiology;Neurodevelopmental Disorder;Neuroglia;Neuronal Dysfunction;Neurons;neuropathology;neuropsychiatric disorder;Oxidative Stress;Oxygen Consumption;Pathway interactions;Patients;Phenotype;Physiology;Predisposition;Property;Pyruvate;restoration;Rett Syndrome;Role;senescence;senescent cell;stem cell model;Structure;targeted treatment;Therapeutic;therapeutic development;Therapeutic Intervention;transcriptome sequencing;United States National Institutes of Health;uptake

PROJECT_TITLE: Investigating mitochondrial dysfunction in human astrocytes with RTT-causing MECP2 mutations

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Narrative GSDMs and NINJ1 are associated with many human diseases, and deletion of GSDMD or NINJ1 significantly decreases pyroptosis, and remarkably protects mice from sepsis. Genetic mutations in GSDMA3, GSDME or DFNB59 cause alopecia and hyperkeratosis in mice and nonsyndromic hearing loss in humans, while polymorphism of GSDMB is linked to increased asthma and IBD risk. Elucidating the structural mechanism of pore formation by GSDMs will have significant impact on generating potential therapeutics against these diseases.

PI_NAMEs: WU, HAO  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Affect;Alopecia;Alzheimer's Disease;Asthma;Binding;Biochemical;Biology;C-terminal;Cardiovascular Diseases;CASP1 gene;Caspase;Cell Death;Cell membrane;Cell Physiology;Chemicals;Color;Complex;Cryoelectron Microscopy;cytokine;cytotoxicity;Data;Dependence;Deuterium;Disease;DNA Sequence Alteration;Exhibits;experimental study;Extravasation;Family;Genetic Polymorphism;Glycine;hearing impairment;Human;human disease;Hydrogen;Hyperkeratosis;Image;immunogenic;In Vitro;in vivo;Inflammasome;Inflammatory;insight;Integral Membrane Protein;Interleukin-1;Interleukin-1 beta;Kinetics;Lactate Dehydrogenase;Length;Link;Lipids;Liposomes;Lytic;Malignant Neoplasms;Mammalian Cell;Mammals;Maps;Mass Spectrum Analysis;Mediating;member;Membrane;Metabolic Diseases;Modification;Molecular;Mus;Mutation;N-terminal;nanodisk;Nervous System Disorder;novel therapeutic intervention;Oxidative Stress Induction;palmitoylation;Paper;Pathway interactions;Pattern;Peptide Hydrolases;Post-Translational Protein Processing;Process;Protein Family;Protein S;Proteins;Publications;Reactive Oxygen Species;Risk;Role;Rupture;Sepsis;Series;Source;Structure;superresolution imaging;Therapeutic;thioester;trafficking

PROJECT_TITLE: Elucidating structural and functional mechanisms of pyroptosis

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Neurosciences;Opioids;Sleep Research

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PHR: PROJECT NARRATIVE In a paper published in PNAS in 2023, we found that two different NOP receptor (NOPR) agonists potently induced sleep and profoundly increased EEG delta power in rats, mice, and non-human primates, suggesting that the N/OFQ-NOPR system may have a previously unrecognized role in sleep/wake regulation. At the highest doses tested, the magnitude of the NREM sleep and EEG delta power increase induced by either NOPR agonist exceeded that produced by the GABAA agonist zolpidem (AmbienTM, the leading insomnia medication). Since our studies to date have been based on use of exogenous compounds, in this proposal, we will test the hypothesis that the N/OFQ-NOPR system is a component of the endogenous sleep/wake regulatory system.

PI_NAMEs: KILDUFF, THOMAS S (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Absence of pain sensation;Affect;Agonist;antinociception;Area;Body Temperature;Brain;Brain region;Cell Nucleus;Cells;chronic pain;chronic pain management;Corticotropin-Releasing Hormone;Darkness;Dose;Electroencephalography;Electron Microscope;epidemiology study;Exhibits;follow-up;FOS gene;Foundations;Genetic Markers;Glutamates;Habenula;hypocretin;Internal Ribosome Entry Site;Interruption;Knockout Mice;Label;Lateral;Light;Light Microscope;Methods;Modeling;Mouse Strains;mRNA Expression;mu opioid receptors;Mus;neural;Neuroanatomy;Neurons;neurotransmission;nociceptin;non rapid eye movement;nonhuman primate;novel;Opiate Addiction;Opioid;Opioid agonist;Optics;ORL1 receptor;Other Genetics;Overdose;Pain;Paper;Peptides;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Physiology;Population;prepronociceptin;prescription opioid misuse;Publishing;Rattus;receptor;receptor expression;Regulation;Rewards;Rodent;Role;Sleep;Sleeplessness;Stress;Structure;System;Tamoxifen;Testing;Virus;Wakefulness;zolpidem

PROJECT_TITLE: Nociceptin, NOPR and Sleep/Wake Control

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative No treatment currently exists for Alzheimer’s-induced impairments of memory formation, a devastating symptom contributing to the massive toll of the disease. This project will investigate circuit mechanisms for associative memory impairment in the lateral entorhinal cortex. The project is expected to yield advances towards the development of therapeutics to rescue memory function processed in the lateral entorhinal cortex.

PI_NAMEs: IGARASHI, KEI M (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Affect;Age;Age Months;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Animal Model;Animals;Association Learning;Atrophic;Brain;Categories;cell type;Cells;Cues;Data;Deep Brain Stimulation;Dementia;design;Deterioration;Dimensions;Disease;Dopamine;Electrophysiology (science);entorhinal cortex;Exhibits;feeding;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Hippocampus;histological studies;Impairment;in vivo;Individual;Investigation;Knock-in;Knock-in Mouse;Knowledge;Laboratories;Lateral;Maps;Medial;Memory;memory acquisition;memory encoding;Memory impairment;Methods;Molecular;Mus;neural circuit;neuronal circuitry;Neurons;optogenetics;Patients;Performance;Persons;Phase;Photometry;prevent;Process;Rattus;Reporting;Research;Retrieval;Rewards;Sensory;sensory input;Signal Transduction;Site;spatial memory;Symptoms;tau Proteins;Testing;Therapeutic;therapeutic development;Ventral Tegmental Area;WFS1 gene;Wild Type Mouse

PROJECT_TITLE: Lateral entorhinal cortex dysfunction in an APP knock-in model of Alzheimer's disease

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative The proposed research is relevant to public health because a better understanding of risk in obsessive- compulsive disorder (OCD) across ancestral populations will lead to improved methods for prevention and treatment for all. This proposal focuses on rare genetic variation, which is understudied in OCD, and proposes to investigate risk for OCD in people of African/African American ancestry, which are under-represented in prior studies. It is relevant to the NIH mission of understanding risk architecture for mental illness including in diverse populations.

PI_NAMEs: GRICE, DOROTHY E (contact);HANKERSON, SIDNEY H

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;access disparities;Address;Affect;African;African American;African American population;African ancestry;Age of Onset;American;Anxiety Disorders;Architecture;Black race;Caring;case control;cell type;Clinical;clinical phenotype;cohort;Collection;Communities;comorbidity;COVID-19 pandemic;Data;de novo mutation;Development;Diagnosis;Disease;disorder risk;disorder subtype;DNA;Encapsulated;Etiology;European;focus ultra;Foundations;Gene Expression;Genes;Genetic;genetic architecture;genetic association;Genetic Research;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome wide association study;Genotype;Goals;health disparity;Health Services Accessibility;Heritability;High-Throughput Nucleotide Sequencing;improved;Individual;innovation;insertion/deletion mutation;Knowledge;Latin American;Maps;Mental disorders;Mental Health;Methods;Mission;Molecular;Mutation;new therapeutic target;non-genetic;novel;novel therapeutics;Nucleotides;Obsessive-Compulsive Disorder;Outcome;Participant;Pathogenesis;Pathway interactions;Patient Self-Report;Persons;Phenotype;Play;polygenic risk score;Population;Population Heterogeneity;Predisposition;Prevention;proband;Public Health;rare variant;recruit;Research;Research Personnel;research study;Research Subject Recruitments;Resources;Risk;risk variant;Role;Sampling;Severities;sex;Site;societal costs;Statistical Methods;Subgroup;Testing;therapeutic target;therapy resistant;transmission process;treatment center;treatment disparity;treatment research;United States National Institutes of Health;Variant

PROJECT_TITLE: Phenotypic and genetic architecture of OCD in African Americans

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Brain Disorders;Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Nutrition;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Narrative Many patients suffering from Post-Acute Sequelae (PASC) fulfill the clinical diagnostic criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Understanding whether PASC ME/CFS shares overlapping mechanisms with non-PASC ME/CFS is critical, as this could provide insights into the mechanisms and inform treatment strategies of ME/CFS in general. In this project, we aim to conduct non-invasive brain magnetic resonance imaging (MRI) to compare the similarities and differences in cerebral oxygen and glucose metabolism between the two patient groups as well as healthy controls, correlating these MRI derived parameters with patient reported outcome measures and study the effects over time.

PI_NAMEs: XU, XIANG  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: 2019-nCoV;Acute;Address;arterial spin labeling;Arteries;Back;Brain;brain magnetic resonance imaging;burden of illness;Cerebrovascular Circulation;Cerebrum;Chronic Fatigue Syndrome;Clinical;clinical diagnostics;Coupled;COVID-19;Data Analyses;density;design;detection sensitivity;Diagnosis;diagnostic criteria;Dimensions;Disease;Energy Metabolism;Equipment and supply inventories;Exertion;experience;Fatigue;feeding;flexibility;flu;follow-up;Follow-Up Studies;Glucose;glucose metabolism;glucose uptake;Heterogeneity;Image;Impaired cognition;improved;in vivo;indexing;Infusion procedures;insight;intravenous injection;Knowledge;Learning;Long COVID;longitudinal analysis;Magnetic Resonance Imaging;Malaise;Measurement;Measures;Metabolic;metabolic rate;Metabolism;Methods;mitochondrial dysfunction;Motion;next generation;Onset of illness;Outcome Measure;Outcome Study;Oxygen;Patient Outcomes Assessments;Patients;Perfusion;Phase;Phlebography;Physical Function;Physiologic pulse;Post-Acute Sequelae of SARS-CoV-2 Infection;Preparation;Property;reconstruction;Reporting;Rotation;Scheme;Signal Transduction;Symptom Burden;Symptoms;Techniques;Technology;temporal measurement;Testing;Time;treatment strategy;uptake;Venous;Virus;Work

PROJECT_TITLE: Cerebral Energy Metabolism in ME/CFS with and without PASC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CFS-J (80)]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE This research project aims at determining how sensorimotor cortex in nonhuman primates contributes to the control of volitional adjustments to locomotion in an adaptive manner. The ability to modify gait with precise, voluntary adjustments is what allows animals to navigate complex terrains and to execute skilled actions during ongoing pursuits. Beyond the relevance to the basic neuroscience of sensorimotor control of locomotion, the aims of the project are essential for the development of new mobility therapies, including brain-machine interfaces, for restoring walking and volitional leg control in people with paralysis.

PI_NAMEs: BORTON, DAVID ALLENSON (contact);TRUCCOLO, WILSON

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Animals;Area;Automobile Driving;Bicycling;Body mass index;brain machine interface;central pattern generator;Communication;Complex;Consensus;Cortical Cord;Cues;Development;Dimensions;Electric Stimulation;Electroencephalography;Electromyography;Gait;Goals;Health;Hindlimb;Human;Implant;Intervention;Leg;Limb structure;linear transformation;Locomotion;Lower Extremity;Maintenance;Maps;Mechanics;Microelectrodes;Monitor;Motion;Motor;Motor Cortex;Movement;Muscle;Nervous System;neural;Neurons;Neurosciences;Neurostimulation procedures of spinal cord tissue;nonhuman primate;Output;Paralysed;Pathway interactions;Periodicity;Persons;Phase;Plants;Play;Primates;Pyramidal Tracts;Reflex action;Research;Research Project Grants;restoration;Role;Signal Transduction;Skeletal Muscle;skills;Speed;Spinal;Spinal Cord;Spinal cord injury;Stream;TACSTD2 gene;Testing;Time;Training;translational applications;treadmill;virtual environment;Visual;Walking;wireless;Work

PROJECT_TITLE: Volitional Control of the Nonhuman Primate Lower Limbs

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Narrative: In our eyes, there are special cells called photoreceptor neurons that help us see. We want to understand why proteins in the photoreceptor neurons get misplaced and cause blindness, as well as study how the different parts of the cells are organized and supported by a structure called the cytoskeleton.

PI_NAMEs: IMANISHI, YOSHIKAZU  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;Afferent Neurons;Affinity Chromatography;Anabolism;Architecture;Area;Binding;Binding Proteins;Biochemical;Biochemistry;Biogenesis;Blindness;C-terminal;Carrier Proteins;Cell membrane;Cell Separation;Cell Shape;Cells;Cellular biology;Cellular Membrane;Cilia;ciliopathy;Complex;Comprehension;Cytoskeleton;Dedications;Defect;Degenerative Disorder;Diffusion;Disease;Down-Regulation;Elements;Ensure;Eye;G-Protein-Coupled Receptors;Health;Imaging Techniques;Inherited;Knock-in;Knock-in Mouse;Label;Learning;Mass Spectrum Analysis;Mediating;Membrane;membrane biogenesis;Membrane Proteins;Methods;Microscopy;Modeling;Molecular Biology Techniques;Monitor;Morphogenesis;mouse model;Mutation;Nature;Neurons;novel;novel therapeutic intervention;novel therapeutics;Pathogenicity;Pathologic;photoreceptor degeneration;Photoreceptors;Phototransduction;polarized cell;Process;Protein Biosynthesis;Protein Sortings;protein transport;Proteins;Proteomics;Research;Retina;Retinal Degeneration;Retinal Diseases;retinal rods;Retinitis Pigmentosa;Rhodopsin;Rod;Role;segregation;Sensory;Signal Transduction;Site;Sorting;Structure;Study models;superresolution imaging;Tail;Techniques;Technology;Testing;Toxic effect;trafficking;Vision;Visual impairment;Visualization;Work

PROJECT_TITLE: Membrane compartmentalization in photoreceptor health and disease

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Orphan Drug;Rare Diseases;Tuberculosis

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE Drug-resistant tuberculosis is a major global cause of morbidity and mortality with the need for rapid, accurate drug susceptibility tests that can be performed outside of centralized labs. We will develop a highly-multiplexed CRISPR TB drug susceptibility test to achieve comprehensive, accurate, and adaptable drug susceptibility results, while integrating simplified workflows to enable deployment in settings closer to the patient.

PI_NAMEs: MYHRVOLD, CAMERON AMADEUS;XIE, YINGDA LINDA (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Address;Africa;Architecture;assay development;Automation;bacterial resistance;Benchmarking;Biological Assay;Clinical;clinical diagnosis;clinical implementation;Clinical Treatment;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;cost;CRISPR/Cas technology;Decentralization;design;Detection;Development;Diagnosis;Drug resistance;Drug resistance in tuberculosis;Engineering;Epidemiology;Evaluation;falls;Fluoroquinolones;Future;Generations;Genotype;global health;improved;Individual;instrumentation;isoniazid;Laboratories;Linezolid;low and middle-income countries;Machine Learning;machine learning prediction;Manuals;Methods;Microfluidics;Minority;Modification;Molecular;Molecular Diagnostic Testing;Morbidity - disease rate;mortality;Multidrug-Resistant Tuberculosis;mutant;Mycobacterium tuberculosis;next generation;next generation sequencing;participant enrollment;pathogen;Patients;Performance;Peripheral;Pharmaceutical Preparations;Phenotype;Phylogenetic Analysis;Population;Predisposition;prototype;Reporter;Research Personnel;Resistance;resistance mutation;Resources;Rifampin;RNA;Sampling;Signal Transduction;Single Nucleotide Polymorphism;Speed;Sputum;Technology;technology development;technology validation;Testing;Time;transmission process;treatment duration;Tuberculosis;tuberculosis drugs;Universities;uptake;Validation;Variant;Viral;whole genome;Work

PROJECT_TITLE: Development of a highly-multiplexed CRISPR-based TB drug susceptibility test

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE We propose to conduct a community-based longitudinal mixed-methods study characterizing sleep health inequities in a sample of Black sexual minority men across a 12-month period, focusing on upstream determinants (intersectional stigma and discrimination) and downstream consequences (mental health, physical health, and health behavior). Results will elucidate mechanisms through which intersectional stigma and discrimination at individual and structural levels affect sleep health and how compromised sleep health, in turn, contributes to mental and physical health problems in this group. Community input and mixed-methods data will inform future policies and intervention efforts, paving the path to health equity for this underserved group.

PI_NAMEs: DONG, LU  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: actigraphy;Address;Affect;Anxiety;Black race;Characteristics;Communities;community academic partnership;community based participatory approach;community based participatory research;community engagement;community setting;coping;Coping Skills;Data;Data Collection;design;diaries;Dimensions;Discrimination;ethnic minority population;experience;follow-up;food insecurity;Future;Goals;group intervention;Health;Health behavior;health disparity;health equity;health inequalities;Health Promotion;HIV;HIV diagnosis;Housing;housing instability;Individual;Inequity;internalized stigma;Intervention;Interview;Investigation;Link;Measures;Mediating;member;men;Mental Depression;Mental Health;Methods;Moods;Neighborhoods;Outcome;Participant;Pathway interactions;Patient Self-Report;perceived discrimination;Persons;physical conditioning;Play;Policies;Polysomnography;poor sleep;Population;post-traumatic symptoms;Questionnaires;racial minority;racial minority population;racial minority status;Research;Risk;Role;Sampling;sexual minority group;sexual minority men;sexual minority status;Sexually Transmitted Diseases;Sleep;sleep behavior;Sleep Disorders;sleep health;Social Identification;social stigma;social structure;social vulnerability;Stigmatization;Stress and Coping;substance use;Surveys;Time;treatment adherence;Underserved Population;United States National Institutes of Health;Unsafe Sex

PROJECT_TITLE: Examining the Mechanisms and Consequences of Sleep Health Inequities Affecting Black SexualMinority Men

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Lung;Neurosciences;Sleep Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Obstructive sleep apnea (OSA) is the most common type of sleep related breathing disorder characterized by frequent airway collapse during sleep. The goal of the project is to develop an innovative motion robust 3D high resolution dynamic MRI approach to quantitatively discern airway shaping in OSA. The successful completion will overcome major technical challenges in safely quantitating airway collapse during OSA in sleep.

PI_NAMEs: LINGALA, SAJAN GOUD (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;alternative treatment;Anterior;Arrhythmia;automated segmentation;awake;Breathing;Clinical;clinical practice;clinical predictors;Clinical Protocols;Clinical Trials;cohort;Continuous Positive Airway Pressure;Custom;Data;Data Set;Dedications;Dementia;design;Development;Diabetes Mellitus;Drug usage;effectiveness evaluation;Eligibility Determination;Endoscopes;Endoscopy;Evaluation;FDA approved;General Anesthesia;Goals;Hypoglossal nerve structure;Image;Image Analysis;imaging biomarker;imaging modality;imaging system;improved;innovation;Label;Lateral;Lead;Learning;Magnetic Resonance Imaging;Manuals;Medicine;Methods;Modeling;Morphologic artifacts;Motion;novel;Obstructive Sleep Apnea;open source;Operative Surgical Procedures;Otolaryngology;Outcome;Patients;Pattern;Pharmaceutical Preparations;Phenotype;predict clinical outcome;predictive marker;Principal Investigator;Procedures;quantitative imaging;reconstruction;Reporting;Reproducibility;Research;Resolution;respiratory surgery;Risk;Sampling;Scheme;Screening procedure;Shapes;Site;Sleep;Sleep Apnea Syndromes;Slice;soft tissue;spatiotemporal;Speech;Stroke;Structure;success;Techniques;Tongue;tongue root;tool;transfer learning;treatment planning;Validation;Virtual Endoscopy;Visualization

PROJECT_TITLE: Novel 3D Quantitative Dynamic MRI to Characterize Obstructive Sleep Apnea

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Infectious Diseases;Microbiome;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Within a patient’s tumor, malignant cells are surrounded by a network of non-malignant cells including endothelial cells, fibroblasts, and infiltrating immune cells, which collectively contribute to the tumor microenvironment (TME). Recent work has revealed the presence of an intratumoral microbiota within most solid cancers; yet there is a fundamental lack of understanding on how microbes within the TME interact with human components of the tumor, or how they might contribute to disease progression. This proposal seeks to meticulously map the intricate cellular and metabolic landscape of tumor BCMs and their surrounding immune environment to advance mechanistic understanding of host-microbiota interactions within the TME, with the potential to reveal novel approaches for cancer prevent and treatment.

PI_NAMEs: BULLMAN, SUSAN  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Anaerobic Bacteria;Animal Model;Area;Bacteria;bacterial community;Biological Models;Bystander Effect;Cancer Biology;cancer cell;cancer therapy;cancer type;Cell Physiology;Cell Survival;cell type;Cells;Collection;Colorectal Cancer;Colorectal Neoplasms;comparative;Complex;CTLA4 gene;cytokine;Data;Disease Progression;Ecosystem;Endothelial Cells;Environment;epidemiology study;Exclusion;experience;Fibroblasts;Fusobacterium nucleatum;Gastrointestinal Neoplasms;Genetic Transcription;Germ-Free;Goals;host microbiota;host-microbe interactions;Human;Immune;immune cell infiltrate;immune checkpoint;Immune Evasion;immune function;immunoregulation;In Situ;in vivo;Infiltration;innovation;insight;Integration Host Factors;Invaded;Knowledge;Macrophage;malignant mouth neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Maps;Mediating;Metabolic;metabolomics;Microbe;microbial;microbiome analysis;microbiome research;microbiota;Molecular Analysis;mouse model;mouth squamous cell carcinoma;multiple omics;Myeloid Cells;neutrophil;Non-Malignant;Normal tissue morphology;novel;novel strategies;novel therapeutics;Nutrient;pathogen;Patients;permissiveness;Phenotype;Population;Predisposition;prevent;Production;programmed cell death protein 1;programs;Proteins;recruit;Recurrent disease;Resistance;Resolution;Role;Shapes;single-cell RNA sequencing;Solid;Spatial Distribution;T cell infiltration;T-Lymphocyte;Technology;Testing;therapy resistant;Tissues;transcriptomics;tumor;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor Tissue;Tumor-infiltrating immune cells;Up-Regulation;Vascularization;Work

PROJECT_TITLE: Defining the landscape of bacterial-colonized microniches in tumors and their role in intratumoral heterogeneity.

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Disability Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases;Zika Virus

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative This research will characterize language development and auditory function in young children who were exposed prenatally to the Zika virus. Altered auditory neural processing, even when hearing sensitivity is normal, can affect language development. This work will help to identify biological and postnatal environmental factors that contribute to increased risk for language and communication difficulties in children with prenatal exposure to viruses and provide novel information for detection and treatment.

PI_NAMEs: HOOD, LINDA J. (contact);KEY, ALEXANDRA

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 4 year old;Address;Adverse effects;Affect;Age;Auditory;Auditory Physiology;Auditory system;Behavioral;Biological;Biological Factors;Birth;Brazil;Characteristics;Child;Childhood;Clinical;Cognitive;cognitive development;cognitive disability;cognitive skill;cohort;Collaborations;Communication;Communication difficulty;Complex;Cross-Sectional Studies;Data;Detection;Development;Early identification;Education;Environmental Risk Factor;epidemic virus;Exhibits;Exposure to;Fetal Development;fetus at risk;Future;Hearing;hearing impairment;improved;Incidence;Individual;infancy;Infant;Intervention;Knowledge;Language;Language Development;Language Disorders;language outcome;literacy;Long-Term Effects;longitudinal design;Longitudinal Studies;Measures;Medical History;Microcephaly;Modeling;Motor;Neonatal Screening;neural;neurodevelopment;Neurophysiology - biologic function;non-verbal;novel;Nursery Schools;Only Child;Outcome;pandemic disease;Parents;pathogen;Peripheral;phonology;Physiological;postnatal;Pregnancy;prenatal;prenatal exposure;Prospective cohort;Readiness;Recording of previous events;Reporting;Research;Research Personnel;response;Risk;Risk Marker;School-Age Population;Schools;Semantics;Sensory;Severities;sex;skills;social;social skills;socioeconomics;Speech;Stimulus;success;Symptoms;syntax;Testing;Time;Toxin;United States;Viral;Virus;Visit;Work;Zika Virus;ZIKV exposure

PROJECT_TITLE: Long-term language outcomes in children with prenatal virus exposure

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Pediatric;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Adult survivors of CHD are the fastest growing group of CHD patients, approximating 40,000 per year, and with more adults now living with CHD than children; yet obstacles to transitioning from pediatric to adult care puts them at risk for significant morbidity and mortality. In this proposal, we aim to reduce care disparities in young adults with CHD by: 1) understanding geographic access and use of patient navigation to adult CHD services for high-risk populations (rural, minority and low socioeconomic status), 2) identifying barriers for transitioning successfully from pediatric to adult-oriented cardiac health services and partnering with adult CHD experts to actively re-engage high-risk patients in appropriate ACHD care, and 3) exploring novel medical shared care delivery models to increase the adult CHD workforce and improve long-term morbidity and mortality for this rapidly expanding population. We also propose to create the infrastructure for a novel REsearch And Career Health Equity System (REACHES) program to train a new generation of pediatric health disparities researchers.

PI_NAMEs: LOPEZ, KEILA NATILDE (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: access disparities;Address;Adult;Advocacy;Affect;aged;barrier to care;Cardiac health;career;Caring;Censuses;Child;Child Health;Childhood;Chronic;Chronic Disease;Collaborations;college;Congenital Abnormality;congenital heart abnormality;Consultations;Data;data resource;Disease Management;disease model;Disparity;Environment;Epidemiology;Equity;equity, diversity, and inclusion;ethnic minority;experience;Expert Systems;Explosion;Face;Failure;Fostering;Generations;geographic barrier;geographic disparity;Geographic Distribution;Geographic Information Systems;Geography;Goals;Grant;Health;health disparity;health equity;Health equity research;health inequalities;Health Policy;Health Professional;Health Services;Health Services Accessibility;Heart;high risk;high risk population;higher education;Home;Improve Access;improved;Infrastructure;innovation;Intervention;Interview;Justice;Laws;Leadership;Learning;life span;Long-Term Effects;low socioeconomic status;Maps;Medicaid;Medical;medical specialties;Medicine;Mentorship;Methods;Minority;Minority Groups;minority patient;Modeling;Morbidity - disease rate;mortality;mortality risk;National Institute on Minority Health and Health Disparities;Nature;novel;Outcome;Output;palliate;Participant;Pathway interactions;Patient Care;patient navigation;Patients;Pediatric Hospitals;pediatrician;Perception;Physicians;Population;Population Heterogeneity;Population Sciences;preservation;Process;programs;Provider;racial minority;Reduce health disparities;Registries;remote delivery;Research;Research Design;Research Personnel;response;Rewards;Risk;Rural;rural environment;rural patients;Service delivery model;Services;simulation;skills;sociodemographics;Socioeconomic Status;socioeconomics;Specialist;statistics;Surveys;Survivors;System;Telemedicine;Texas;Time;tool;Training;Training Support;Underrepresented Minority;United States National Institutes of Health;Writing;young adult

PROJECT_TITLE: Transforming Care Delivery Models for at-Risk Young Adult Patients with Congenital Heart Disease and Amplifying Research Efforts to Improve Health Equity in Pediatric Chronic Disease Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (55)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Natural Products;Rare Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Despite their potential to prevent and treat gut infections, microcins remain severally understudied. We have developed computational and cell-based approaches that show microcins are widespread among Gram-negative bacteria and have identified potent examples effective against the gut pathogen Vibrio cholerae. Through this proposal we will uncover sequence-activity relationships controlling microcin activity and explore cell-based vectors to deliver them and treat V. cholerae intestinal infections.

PI_NAMEs: DAVIES, BRYAN WILLIAM (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Active Biological Transport;Affect;Anti-Bacterial Agents;Antibiotics;Bacteria;Bacterial Proteins;bacterial vector;bacteriocin;Binding;Biology;Cells;Characteristics;Cholera;Clinical;Coupling;Data Set;delivery vehicle;Development;diarrheal disease;Disease Outbreaks;Dose;empowerment;enteric infection;Environment;Equus caballus;Etiology;Exclusion;Gram-Negative Bacteria;Growth;host microbiome;improved;in silico;in vivo;Infection;innovation;Knowledge;Membrane;Membrane Proteins;Methods;microcin;mouse model;Mus;Natural Products;novel strategies;Oral;pathogen;pathogenic bacteria;Performance;periplasm;Permeability;Persons;Pharmacology;Phylogenetic Analysis;prevent;Proteins;receptor;receptor binding;Research;Route;scaffold;screening;siderophore receptors;Siderophores;System;Testing;Therapeutic;Transport Process;Validation;vector;Vibrio;Vibrio cholerae;Vibrio cholerae infection;Vibrionaceae;Work

PROJECT_TITLE: Vibrio microcins. A hidden field of targeted anti-cholerae natural products.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: NARRATIVE  Alzheimer’s disease (AD) is the most common neurodegenerative disease with no efficacious treatments. Our study will determine whether the Hippo signaling pathway, an evolutionarily conserved pathway that regulates cell growth and cell survival, is a potential therapeutic target for AD.

PI_NAMEs: RAN, QITAO  (contact)

PROJECT_TERMS: Ablation;Alzheimer's Disease;Alzheimer's disease brain;American;Animal Disease Models;Attenuated;Brain;Cell Death;cell growth;Cell Nucleus;Cell Proliferation;Cell Survival;Cognition;cognitive function;Complex;conditional knockout;Cytoplasm;Data;Dementia;Development;Disease;Disease Progression;effectiveness evaluation;efficacious treatment;Event;experimental study;gene repression;Genes;Genetic;genetic approach;Hippocampus;Huntington Disease;improved;Intervention;Iron;Knock-out;Knowledge;LATS1 gene;LATS2 gene;Lipid Peroxidation;Membrane;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;neuroprotection;novel;novel therapeutic intervention;Onset of illness;organ growth;Organ Size;overexpression;Pathogenesis;Pathway interactions;Phosphorylation;Phosphotransferases;promote resilience;Prosencephalon;Reporting;resilience;Resistance;Signal Pathway;Signal Transduction;small molecule inhibitor;symptom management;Testing;therapeutic target;Transcription Coactivator

PROJECT_TITLE: The Hippo signaling pathway as a target of intervention for Alzheimer’s disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Chronic Pain;Interstitial Cystitis;Neurosciences;Pain Research;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating syndrome of unknown etiology. This proposal seeks to understand the spinal mechanism that plays a role in bladder sensation and overactive bladder. A comprehensive understanding of the spinal mechanisms will provide new avenues for targeted interventions in treatment of IC/BPS patients.

PI_NAMEs: SAMINENI, VIJAY K (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Affect;anatomical tracing;Anatomy;associated symptom;Attenuated;Behavioral;Bladder;bladder pain;Brain;Cell Nucleus;cell type;Cells;Central cord canal structure;central sensitization;Chronic;Clinical;Clinical Research;Cystitis;Development;Dorsal;dorsal column;effective therapy;Electrophysiology (science);Esthesia;Etiology;Exhibits;Fiber;Functional disorder;Genetic;Gray Commissure;Human;Increased frequency of micturition;insight;Interneurons;Interstitial Cystitis;Intervention;Knowledge;Local Therapy;Mediating;Micturition Reflex;midbrain central gray substance;Minority;Modality;mouse model;Mus;neural circuit;Neurons;Nociception;optogenetics;Organ;Output;Overactive Bladder;Pathologic;Pathology;Pathway interactions;Patients;Pelvic Pain;Pelvis;Pharmaceutical Preparations;pharmacologic;Play;Population;Positioning Attribute;pressure;Primates;Process;Regulation;response;Rodent;Role;Seminal;Sensory;side effect;Signal Transduction;Site;Slice;Spinal;Spinal Cord;spinal pathway;Symptoms;Synapses;Syndrome;Testing;Therapeutic;transmission process;United States;Urination;Visceral;Visceral pain;Woman;Work

PROJECT_TITLE: Spinal Mechanisms Underlying Interstitial Cystitis/Bladder Pain Syndromes (IC/BPS)

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Adoptive T cell therapy (ACT) has the potential to revolutionize cancer treatment by utilizing the immune system to target cancer cells. However, T cell exhaustion and the absence of stem cell memory T cells pose challenges to the effectiveness of ACT. We aim to enhance ACT by improving T cell phenotypes through epigenetic programming. By identifying key targets and gene regulatory regions associated with T cell exhaustion via high- throughput genetic and epigenetic screening, we will use epigenome editing to manipulate these factors and improve T cell function for better tumor control. This work will establish a framework for epigenetic engineering in human T cells and advance the development of an improved ACT platform.

PI_NAMEs: GERSBACH, CHARLES A. (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Acute;Address;Advanced Development;Animal Model;Antibody Therapy;Antigens;Automobile Driving;cancer cell;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Cellular immunotherapy;Chromatin;Chronic;Clinic;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Code;combinatorial;Complex;CRISPR interference;Data;Development;Distal;effective therapy;Effectiveness;Elements;engineered T cells;Engineering;Epigenetic Process;epigenome editing;epigenomic profiling;exhaust;exhaustion;experience;Gene Combinations;Gene Expression;gene interaction;Genes;Genetic;Genome;Goals;high dimensionality;Human;Immune;Immune system;improved;improved outcome;Individual;innovation;insight;knockout gene;Knowledge;Lead;Libraries;Link;manufacture;multidisciplinary;multimodality;Mus;next generation;Nucleic Acid Regulatory Sequences;Organoids;overexpression;Patient-Focused Outcomes;Patients;personalized intervention;personalized medicine;Phenotype;preclinical trial;programs;Proliferating;receptor;Regulation;Regulatory Element;response;screening;Signaling Molecule;stem cell exhaustion;stem cells;Surface;T cell differentiation;T cell regulation;T cell response;T cell therapy;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Technology;Therapeutic;therapy outcome;Therapy trial;tool;transcription factor;transcriptomics;Translating;Treatment outcome;tumor;Tumor Antigens;Untranslated RNA;Work;Xenograft Model

PROJECT_TITLE: Epigenetic Programming of T Cells for Enhanced Cellular Immunotherapy

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Prostate Cancer;Rare Diseases;Urologic Diseases

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE Our laboratory previously identified a variant of small cell lung cancer (SCLC) which lacks neuroendocrine identity, but instead resembles the tuft cell lineage, which has been clinically validated and is now referred to as SCLC-P. The goal of this proposal will be to reveal the unique biology and molecular vulnerabilities of SCLC-P, an aggressive tumor subtype defined POU2F3 expression and dependency. This project will integrate the latest innovations in molecular epigenetics together with novel genetic models of this disease to explore the emergent biological properties of this distinct tumor lineage.

PI_NAMEs: VAKOC, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Ablation;Acute;Adenocarcinoma;Amino Acids;Androgen Antagonists;Androgen Receptor;Binding;Biochemical;Biochemistry;Biologic Characteristic;Biological;Biological Assay;Biological Markers;Biology;Cancer cell line;Cancer Gene Mutation;Cancer Model;Carcinoma;Castration;Cell Lineage;Cells;Chromatin Remodeling Factor;Classification;Clinical;Complex;Coupled;CRISPR screen;Cytotoxic Chemotherapy;Data;Dependence;Development;disease model;Disease Progression;driver mutation;Drug resistance;Drug Targeting;Engineering;Epigenetic Process;epigenome;epigenomics;Future;gene complementation;Generations;Genetic;Genetic Models;Genetic Transcription;genome editing;Genotype;Goals;Growth;Histologic;Homeostasis;Human;Human body;immune function;in vivo;innovation;Investigation;Laboratories;Link;Lung;Lung Adenocarcinoma;lung cancer cell;Malignant Epithelial Cell;Malignant Neoplasms;Methods;Modeling;Molecular;molecular subtypes;mouse model;Mus;Mutagenesis;Names;Neoplasm Metastasis;Neoplasms;neoplastic;neoplastic cell;Neuroendocrine Tumors;Neurosecretory Systems;Normal tissue morphology;novel;Oncology;Organ;permissiveness;pharmacologic;pre-clinical;Process;programs;Property;Prostate Adenocarcinoma;prostate cancer model;prostate cancer progression;Proteins;Publishing;Reporter;Reporting;Research;Research Proposals;Resistance;resistance mechanism;Role;Selection for Treatments;small cell lung carcinoma;small molecule;Specimen;Structure;System;targeted treatment;Technology;Therapeutic;therapy resistant;tool;transcription factor;transcriptomics;transdifferentiation;treatment response;tumor;tumor progression;Tumor Subtype;Variant;Work

PROJECT_TITLE: Biology and vulnerabilities of POU2F3+ tuft cell-like carcinomas

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Our overarching goal is to determine whether a newly discovered form of macromolecular organization – protein phase-separation – can explain the strong age dependency of human disease. Recently, it has been increasingly appreciated that many proteins involved in neurodegeneration and other diseases of aging have the capacity to self-associate, condensing to form ‘phase-separated’ compartments called biomolecular condensates. Our proposal leverages comprehensive libraries of human disease alleles along with biochemistry, cell biology, and physiological modeling to investigate and define the contribution of protein phase separation, and aggregation, to the age dependency of human disease processes.

PI_NAMEs: JAROSZ, DANIEL  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Address;Age;age effect;Age of Onset;age related;age related changes;age related decline;age-related disease;Aging;aging related disease;Alleles;alpha synuclein;Attention;Automobile Driving;Behavior;Biochemistry;Biophysics;Caenorhabditis elegans;candidate identification;Cell Line;Cellular biology;Client;Complex;confocal imaging;Data;Defect;defined contribution;Dependence;Diffuse;Disease;disease phenotype;Disease Progression;driving behavior;Equipment and supply inventories;experimental study;Fibroblasts;Fluorescence;Fluorescence Recovery After Photobleaching;follow-up;Foundations;Future;genetic variant;Genetic Variation;Goals;Growth;Heterozygote;Human;human disease;Human Genetics;Image;In Vitro;Individual;Induced Neurons;Kinetics;Libraries;Liquid substance;LRRK2 gene;Measures;Membrane;Molecular Chaperones;Morphology;mutant;Mutation;Nerve Degeneration;Neurons;Onset of illness;Organelles;Partition Coefficient;Pathology;Phase;Phase Transition;Physical condensation;physiologic model;Physiological;Pilot Projects;prion-like;Process;Property;protein aggregation;protein folding;Protein Region;Proteins;Proteome;Quality Control;recruit;Reporter;senescent cell;Shapes;Stress;Techniques;Time;Toxic effect;Training;Variant;Work

PROJECT_TITLE: Investigating protein phase separation and aggregation in age dependent human disease

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: UNIVERSIDAD PERUANA CAYETANO HEREDIA

PHR: PROJECT NARRATIVE Despite significant science, technology, and innovation system growth in Peru, the country’s approach to research ethics has not kept pace, resulting in few scholars in research ethics, scant options for graduate degrees or specialty track in research ethics, and scant original ethics research. Our goal is to increase the quality of research ethics and responsibly conducted health research in Peru. For this, we will provide a master’s degree program and options for advanced education in research ethics and integrity for multidisciplinary professions through practicum experiences, research opportunities, and professional mentoring.

PI_NAMEs: HEITMAN, ELIZABETH ;OCHOA, THERESA J (contact);PAZ-SOLDAN, VALERIE ANDREA

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Biomedical Research;career;career development;Case Study;certificate program;cohort;Collaborations;Complex;Conflict of Interest;Country;course module;COVID-19 pandemic;Degree program;Education;Educational Curriculum;Educational process of instructing;Educational Status;Environment;Ethicists;Ethics;experience;Funding;global health;Goals;Graduate Degree;Growth;Health;health science research;Health Sciences;improved;innovation;insight;Institution;Institutional Review Boards;Instruction;International;Knowledge;Latin America;Libraries;Life;Master of Science;medical schools;medical specialties;member;Mentors;multidisciplinary;online course;Peru;Peruvian;Policy Maker;Policy Making;Population;population health;Predisposition;Productivity;programs;Protocols documentation;Research;Research Design;Research Ethics;Research Ethics Committees;Research Personnel;Research Training;Resources;responsible research conduct;Retinal blind spot;Science;Scientist;Series;skill acquisition;skills;social;Spanish;Students;System;Technology;Texas;Training;Tropical Medicine;United States National Institutes of Health;Universities

PROJECT_TITLE: Research Ethics Training in latinAMericA (RETAMA)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-E (50)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Pregnancy;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will produce rigorous evidence on the impacts of pregnancy dental coverage policies that may inform state decisions to newly adopt or maintain coverage. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to enhancing health and reducing illness. This application is also relevant to the part of NIDCR’s mission that pertains to improving dental, oral, and craniofacial health, and to the part of NIMHD’s mission that pertains to improving minority health and reducing health disparities.

PI_NAMEs: LIPTON, BRANDY  (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Acute;Address;Adopted;Adult;adverse birth outcomes;Affect;Age;aging population;Bacteria;Birth;Black race;black/white disparity;Caring;Child;Childhood;Chronic Disease;cost;Costs and Benefits;Counseling;County;craniofacial;Data Sources;Dental;Dental Care;Dental caries;Dentists;Development;Disease;Disparity;disparity reduction;Eating;Education;Enrollment;Ethnic Origin;experience;Exposure to;Family;Future;Geography;Health;health equity promotion;Health Expenditures;Health Services Accessibility;Health Status;Hispanic;Housing;Immigration;improve minority health;improved;in utero;Income;income disparities;innovation;Insurance;Intervention;Investments;Link;Marketing;Measures;Medicaid;Methods;Mission;Modeling;Monitor;Mothers;National Health Interview Survey;National Institute of Dental and Craniofacial Research;National Institute on Minority Health and Health Disparities;Neighborhood Health Center;Not Hispanic or Latino;Oral;Oral health;Outcome;Pain;Parents;Pattern;Persons;Policies;Policy Maker;Predisposition;Pregnancy;pregnant;Pregnant Women;prenatal;prevent;Preventive;Preventive care;Preventive dental care;Preventive measure;Public Health;Qualifying;Quality of life;Quasi-experiment;Race;Racial Equity;Recommendation;Reduce health disparities;Reporting;reproductive;Research;restorative treatment;Risk;Risk Assessment;Services;sex;Socioeconomic Status;structural determinants;Surveys;System;Testing;Time;Tooth structure;Translating;United States National Institutes of Health;Variant;Vertical Disease Transmission;Visit

PROJECT_TITLE: Impact of Medicaid Pregnancy Dental Benefits on Dental Care Access Among Pregnant People and Young Children

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: GALVESTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE We have generated a novel approach to deliver a natural antiinflammatory protein (interleukin-10) using naturally occurring human cell-derived extracellular vesicles (exosomes) to reduce the risk of infection and inflammation-induced preterm birth. In mouse models, this drug can cross the placenta to treat the fetus and delay preterm birth with no side effects to the mother or the fetus. Before clinical trials in humans, we will conduct various toxicology studies using two animal models of pregnancy (mouse and nonhuman primates) and validate these results using a newly developed humanized intrauterine pregnancy tissue (organ on a chip; Non-Animal Model) before submitting the drug for FDA approval for clinical trials during pregnancy.

PI_NAMEs: ADAMS WALDORF, KRISTINA M.;KAMMALA, ANANTH KUMAR ;MENON, RAMKUMAR  (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: 37 weeks gestation;absorption;Acceleration;Address;Animal Model;Animal Testing;Anti-Inflammatory Agents;Area;Biological Availability;Catheterization;CCL4 gene;Cefazolin;cell type;Cells;Cervix Uteri;Characteristics;Chronic;Circulation;Clinical;Clinical Trials;Complex;cytokine;Cytokine Degradation;cytotoxicity;Data;data modeling;Decidua;design;Devices;Dose;Drug Delivery Systems;Drug Kinetics;drug repurposing;Drug usage;Educational workshop;Effectiveness;Electroporation;Engineering;Escherichia coli;Etiology;Exclusion;exosome;Exposure to;extracellular vesicles;fetal;Fetal Membranes;Fetal Reduction;Fetus;Food and Drug Administration Drug Approval;Future;Half-Life;Histologic;Hour;Human;Immune Tolerance;Immunosuppression;improved;In Vitro;in vitro Model;Incidence;Infection;infection risk;Infectious Agent;Inflammation;Inflammatory;Inflammatory Response;inhibitor;innovation;Interleukin-10;Intervention;intraamniotic infection;Investigation;Knowledge;Laboratories;Lactation;maternal morbidity;maternal risk;Measures;Mediating;Metabolism;microphysiology system;Modeling;Modernization;mortality;Mothers;mouse model;Mus;National Institute of Child Health and Human Development;Neonatal;neonatal morbidity;Neonatal Mortality;neonatal outcome;neonate;neurotoxicity;NF-kappa B;No-Observed-Adverse-Effect Level;nonhuman primate;novel;novel strategies;organ on a chip;Orphan;Pathology;Patients;Persons;Pharmaceutical Preparations;Physiological;Placenta;placental transfer;postnatal;preclinical trial;Pregnancy;Pregnancy Outcome;pregnant;premature;Premature Birth;prenatal;Production;Proteins;pup;Recombinants;Recommendation;Reporting;Reproducibility;reproductive;response;Risk Reduction;Rodent;Route;Safety;side effect;Syndrome;systemic inflammatory response;Testing;Therapeutic;Therapeutic Trials;Tissues;Toxic effect;Toxicokinetics;Toxicology;Uterine Contraction;Uterus;Validation

PROJECT_TITLE: IL-10 Delivery Using Extracellular Vesicles to Delay Preterm Birth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


NIH_SPENDING_CATS: Aging;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE We remain ignorant about the tissue dynamics that govern cancer development during aging or chronic tissue injury. One primary example is liver cancer, which is the third most lethal cancer worldwide and largely develops within a chronically diseased liver. By unraveling the mechanisms by which the most frequent oncogenic mutation in liver cancer interacts with the tissue microenvironment in both healthy and diseased livers, we can potentially unlock novel therapeutic interventions.

PI_NAMEs: FONT-BURGADA, JOAN  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Address;age acceleration;age related decline;aged;Aging;aging related disease;Antioxidants;Apoptosis;Automobile Driving;Autophagocytosis;beta catenin;Cancer Control;cancer initiation;Cell division;Cell Physiology;Cells;Chronic;chronic liver disease;chronic liver injury;Clonal Expansion;Coupling;Critical Pathways;CTNNB1 gene;Data;Development;Disease;endoplasmic reticulum stress;Event;Exhibits;Failure;fitness;FRAP1 gene;Genetic;Glutamine;Growth;Hepatic Tissue;Hepatocyte;Homeostasis;Human;human tissue;in vivo;in vivo evaluation;Incidence;Knowledge;Life;Liver;Liver diseases;liver injury;Location;Malignant neoplasm of liver;Malignant Neoplasms;Molecular;Molecular Analysis;mouse model;Mutate;Mutation;novel;novel therapeutic intervention;old mice;Oncogenes;Oncogenic;Pathway interactions;Patients;Phenotype;Play;Primary carcinoma of the liver cells;Process;Proliferating;Protein Biosynthesis;Proteins;Research;response;Role;single-cell RNA sequencing;stem;Structure;synergism;System;Time;tissue injury;Tissues;tumor;Tumor Suppressor Genes;tumorigenesis

PROJECT_TITLE: Hepatic Tissue Integrity and Clonal Fitness: Key Factors in Controlling β-Catenin Induced Oncogenesis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Autistic adults are more vulnerable to developing early-onset dementia than the general population as they age. This study aims to uniquely quantify dementia-sensitive neurocognitive, brain, and plasma biomarkers in middle- aged autistic adults to reveal pathophysiological mechanisms underlying prodromal dementia in autism spectrum disorder (ASD). The proposed studies will provide foundational insights into dementia pathophysiology in ASD to inform screening, diagnosis, therapeutic plans, and monitoring strategies.

PI_NAMEs: WANG, ZHENG  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Acceleration;Address;adult with autism spectrum disorder;Affect;Age;Aging;Alleles;Alzheimer's disease related dementia;Alzheimer's disease risk;Amygdaloid structure;Amyloid;Amyloid beta-42;Apolipoprotein E;Area;autism spectrum disorder;autistic children;Autopsy;baby boomer;basal forebrain;Behavioral;Biological Markers;Blood;Brain;Brain imaging;California;Categories;Clinical Research;clinically relevant;Cognitive;cognitive testing;comorbidity;comparison control;Cues;Data;Dementia;dementia risk;design;Deterioration;Diagnosis;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;disorder risk;early onset;entorhinal cortex;epidemiology study;Episodic memory;Evaluation;executive function;flexibility;Functional disorder;General Population;Generations;Glial Fibrillary Acidic Protein;gray matter;Health;Healthcare Systems;Hippocampus;Impaired cognition;Impairment;insight;interest;Intervention;Learning;Light;Literature;Magnetic Resonance Imaging;Memory;memory retention;middle age;Monitor;Nerve Degeneration;Neurocognitive;Neurocognitive Deficit;neurofilament;Outcome Measure;Output;Participant;Pathology;Personal Satisfaction;Phase;Plasma;Population;Positron-Emission Tomography;Prevalence;Prevention;Protein Isoforms;Public Health;Quality of Care;recruit;response;Reversal Learning;screening;Semantics;Service provision;sex;Sorting;Staging;structural imaging;targeted treatment;tau Proteins;tau-1;Testing;Therapeutic;Thinness;Time;Trail Making Test;verbal;Verbal Learning;Water;water diffusion;white matter;Wisconsin;Work;β-amyloid burden

PROJECT_TITLE: Quantification of the neurocognitive, brain, and blood markers of dementia in middle-aged autistic adults

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE: RNA editing plays a crucial role in cellular processes to prevent autoimmunity, making aberrant RNA editing a significant factor in the development of autoinflammatory diseases. We aim to employ advanced experimental and computational techniques to identify critical RNA substrates in autoinflammatory diseases. By integrating these substrates into a cumulative score, we seek to enable the stratification and treatment of patients with diverse autoinflammatory conditions.

PI_NAMEs: LI, JIN BILLY  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Accounting;ADAR1;Adenosine;antagonist;Autoimmune;Autoimmune Diseases;Autoimmunity;autoinflammatory;autoinflammatory diseases;Beta Cell;Biochemical;Biological Assay;Birth;Cell Physiology;cell type;Cells;Chronic;combat;Complex;Computational Technique;Computing Methodologies;Coronary Arteriosclerosis;cytosolic receptor;cytotoxic;Data;Detection;Development;Disease;dosage;Double-Stranded RNA;Excision;Exhibits;Filament;gain of function mutation;Gene Expression;Genes;Genetic;genetic approach;Genetic Risk;genetic variant;genome wide association study;Heritability;Human;Human Genetics;Immune;immunogenic;immunogenicity;Immunologic Receptors;Impairment;Individual;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Innate Immune Response;Inosine;insight;Insulin-Dependent Diabetes Mellitus;Interferons;islet;Knowledge;large datasets;Life;life span;Ligands;loss of function;loss of function mutation;Maps;Measures;Mediating;Methods;Modeling;mouse model;Multiple Sclerosis;Mus;Natural Immunity;novel;Parkinson Disease;Pathogenicity;Patient risk;patient stratification;Patients;Pattern recognition receptor;personalized medicine;personalized therapeutic;Pilot Projects;Play;polygenic risk score;predictive modeling;prevent;Production;Property;Proteins;pseudotoxoplasmosis syndrome;receptor;Research;response;Rheumatoid Arthritis;risk variant;RNA;RNA Editing;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stratification;Synovial joint;Therapeutic;Tissues;Up-Regulation;Validation;Variant;Viral;viral RNA;Work

PROJECT_TITLE: Systematic identification and characterization of immunogenic double-stranded RNAs

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: TUSCALOOSA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: PROJECT NARRATIVE The automobile towing industry is one of the most dangerous jobs in the US, with the highest fatality rate among all private industries. Despite this, it has received little attention and research, as highlighted at the National Occupational Injury Research Symposium. This proposal addresses this gap by identifying interventions that could reduce the risk of struck-by traumatic injuries among tow truck operators, in alignment with the National Institute of Occupational Safety and Health 2019-2026 Strategic Plan (“Improve workplace safety to reduce traumatic injuries”).

PI_NAMEs: LIU, JUN  (contact);PENMETSA, PRAVEENA ;STAVRINOS, DESPINA

PROGRAM_OFFICER_NAME: CHIOU, SHARON

PROJECT_TITLE: A Multidisciplinary Approach for Tow Truck Operator Safety

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Kidney Disease;Organ Transplantation;Transplantation

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: 11 Project Narrative Every year, tens of thousands of people in the United States await a life-saving kidney transplant; however, there exists a major shortage in transplants that is at least partially due to a high discard rate of transplant- quality deceased-donor kidneys. Our preliminary research suggests that widely varying thresholds for accepting a deceased-donor kidney among doctors may contribute to the high discard rate. To address this issue, our proposed study investigates how doctors make decisions about accepting kidneys for transplantation, aiming to reduce medically unjustifiable discards and save more lives by informing the future development of targeted interventions to improve the transplantation system.

PI_NAMEs: GREEN, ELLEN P (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Address;Age;Agreement;Behavioral;behavioral economics;Belief;Biopsy;Body mass index;Cause of Death;Characteristics;Clinic;Clinical;Collaborations;Costs and Benefits;Data;Data Linkages;Data Set;Decision Making;Development;Dialysis procedure;econometrics;End stage renal failure;Enrollment;Ensure;experience;Future;Health;Heterogeneity;improved;In Situ;indexing;Individual;insight;Intervention;Kidney;Kidney Diseases;Kidney Transplantation;Knowledge;Lead;Length;Life;Maintenance;Measures;Mediation;Medical;Medical center;multilevel analysis;novel;Operative Surgical Procedures;Organ;Outcome;patient population;Patient-Focused Outcomes;Patients;Pattern;Persons;Phase;Policies;Population;post-transplant;Process;Quality of life;Recording of previous events;Records;recruit;Reporting;Research;Resources;Risk;Source;Surveys;System;Time;trait;transplant centers;Transplant Recipients;Transplantation;United States;United States Health Resources and Services Administration;Update;Variant;Waiting Lists

PROJECT_TITLE: Identifying Behavioral Factors Contributing to High Discard Rate of Deceased Donor Kidneys