ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: OVERALL – PROJECT NARRATIVE Nearly 1 in 54 children will be diagnosed with Autism Spectrum disorder (ASD), which is associated with life - long challenges. Other common neurodevelopmental disorders (NDDs), including attention-deficit and hyperactivity disorder, intellectual disability, seizure disorders, and traumatic injury to the developing brain, also have major social and economic costs associated. This initiative will establish a center of research excellence in Neurodevelopment and Its Disorders in South Carolina, where the rate of ASD is estimated to be higher, that will ultimately improve the health and well-being of individuals diagnosed with NDDs, including ASD.

PI_NAMEs: COWAN, CHRISTOPHER W (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Animal Model;Animals;Area;Attention deficit hyperactivity disorder;autism spectrum disorder;Basic Science;Behavioral;behavioral phenotyping;Bioinformatics;Biological Markers;Biology;biomarker discovery;Brain;Brain imaging;brain research;career;career development;cell type;Centers of Research Excellence;Child;Clinical;Clinical Research;Collaborations;college;Communities;Complement;computer infrastructure;Department chair;Development;Diagnosis;Disease;disorder risk;economic cost;Environment;Epilepsy;Equipment;Evaluation;experience;Explosion;Faculty;Fostering;Functional disorder;Funding;Future;Gene Expression;Genetic;Genomics;Goals;Grant;Health;Human;human model;Image;Imaging technology;Impaired cognition;improved;in vivo;Individual;individuals with autism spectrum disorder;innovation;Institution;Intellectual functioning disability;Interdisciplinary Study;Investments;Leadership;Link;Medical;Medicine;member;Mentors;Mission;Modernization;Molecular;Molecular Neurobiology;multidisciplinary;Mus;neural;neurodevelopment;Neurodevelopmental Disability;Neurodevelopmental Disorder;Neurosciences Research;new growth;novel;novel therapeutic intervention;Pathology;Peer Review;Personal Satisfaction;Phenotype;Pilot Projects;programs;Psychologist;Publications;recruit;Research;Research Infrastructure;Research Personnel;Research Training;Resources;Scientist;social;Source;South Carolina;success;Symptoms;synergism;Systems Development;Technology;Training;training opportunity;Translational Research;Traumatic injury;United States National Institutes of Health;Universities;Vision;Writing

PROJECT_TITLE: COBRE in Neurodevelopment and Its Disorders


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: LITTLE ROCK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PI_NAMEs: NOOKAEW, INTAWAT  (contact)

PROJECT_TERMS: Address;Algorithms;analysis pipeline;Arkansas;Big Data;Big Data to Knowledge;Bioinformatics;Biological;biological systems;Biology;biomechanical test;Biomechanics;bone;bone imaging;Cell Physiology;Cells;Communities;Competence;Computational algorithm;Computer Analysis;computer framework;computerized data processing;computing resources;Consultations;Custom;Data;Data Analyses;Data Analytics;Data Collection;data repository;Data Set;Data Storage and Retrieval;Databases;Development;Dimensions;Disease;effective therapy;Environment;Equipment;experience;experimental study;Functional disorder;Generations;Genetic Models;genome-wide;Goals;high dimensionality;High Performance Computing;high throughput technology;Histologic;Histology;Human Resources;human tissue;Image;Image Analysis;Individual;Information Retrieval;Institution;Knowledge;Knowledge Discovery;large datasets;large scale data;Leadership;Medical;meetings;member;Methods;Mining;Molecular;Monitor;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal System;Pathway interactions;Procedures;Process;Publishing;Research;Research Personnel;Research Project Grants;Research Subjects;Resources;Sampling;Science;Services;single-cell RNA sequencing;skills;success;synergism;Systems Biology;Technology;Training;Training and Education;training project;transcriptome;transcriptomics;United States National Institutes of Health;Universities;web portal;Work

PROJECT_TITLE: Bioinformatics Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PROJECT_TERMS: Accountability;Address;Advisory Committees;Basic Science;Biomedical Research;Biometry;Biostatistical Methods;career;career development;Centers of Research Excellence;Collaborations;Development;Development Plans;Disease;Doctor of Philosophy;Effectiveness;Elements;Ensure;Evaluation;experimental analysis;Experimental Designs;Extramural Activities;Faculty;Fostering;Funding;Future;Goals;Individual;Information Dissemination;Infrastructure;Institution;Leadership;Medical;Mentors;Monitor;multidisciplinary;neurodevelopment;Neurodevelopmental Disorder;novel;operation;Peer Review;Pilot Projects;Program Evaluation;programs;Recommendation;recruit;remediation;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resources;Scheme;Scientist;Series;Services;sound;Source;South Carolina;success;synergism;Teacher Professional Development;Training;Universities

PROJECT_TITLE: Administrative & Mentoring Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences

PROJECT_TERMS: Algorithmic Analysis;analysis pipeline;Applications Grants;Artificial Intelligence;Bioinformatics;Biomedical Computing;biomedical scientist;Biometry;Cell Separation;Cells;Centers of Research Excellence;Cloud Computing;Code;code development;Communities;Complex;computer infrastructure;Computer software;Computer Systems;Custom;Data;data acquisition;Data Analyses;data analysis pipeline;Data Collection;data management;Data Science;Data Set;data sharing;data visualization;design;Disease;diverse data;Environment;epigenomics;Equity;experience;Experimental Designs;Fee-for-Service Plans;Future;Gene Expression Profiling;genetic analysis;genome sequencing;Genomic approach;genomic data;Genomics;Goals;high end computer;Image Analysis;Infrastructure;Interdisciplinary Study;interest;Language;Leadership;member;Mentors;Mentorship;Modernization;multiple omics;neurodevelopment;next generation;next generation sequencing;novel;peer;peer coaching;Pilot Projects;Preparation;Programming Languages;Publications;Quality Control;repository;Research;Research Design;Research Personnel;Research Project Grants;Resources;Sampling;success;Technology;theories;Training;transcriptomics;Update;Vertebral column;whole genome

PROJECT_TITLE: Genomic and Bioinformatic Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Congenital Structural Anomalies;Genetics;Osteogenesis Imperfecta;Pediatric;Rare Diseases

PI_NAMEs: ONAL, MELDA  (contact)

PROJECT_TERMS: Address;Affect;Apoptosis;Autophagocytosis;Autophagosome;Biogenesis;Biomechanics;bone;Bone Formation Stimulation;bone mass;Bone Matrix;Bone remodeling;Bone Resorption;bone strength;Bone Surface;Cell Lineage;cell type;Cells;Cellular Stress;Cessation of life;Collagen;conditional knockout;CRISPR-mediated transcriptional activation;cytokine;endoplasmic reticulum stress;Fracture;Functional disorder;Genes;Genetic;genetic approach;Human;improved;in vivo;Individual;Induction of Apoptosis;insight;Knockout Mice;Lysosomes;Measures;mechanical load;Mechanics;Mediating;Membrane;Modeling;Molecular;Molecular Chaperones;mouse model;Mus;Musculoskeletal Diseases;new therapeutic target;novel;Organelles;osteoblast differentiation;osteoblast proliferation;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;Osteogenesis Imperfecta;Pathology;Pathway interactions;Phenotype;prevent;Process;Production;progenitor;Proliferating;protein aggregation;Proteins;proteostasis;Recycling;Research;response;restraint;Role;Signal Transduction;single-cell RNA sequencing;skeletal;skeletal disorder;stressor;System;Therapeutic Intervention;tibia;TNFSF11 gene;trafficking;transcription factor;Vesicle

PROJECT_TITLE: The role of autophagy in bone remodeling


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: MILWAUKEE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative The evolving needs of the specialty of Anesthesiology include: a strengthening of the scientific foundation to grow new fundamental insights and offer the highest quality of care to the expanding complex patient population requiring anesthesia perioperative care. The purpose of the STAT Training Program is to develop a subset of outstanding investigators trained to conduct precise and impactful research of relevance to anesthesiology and perioperative medicine. This new application will build upon our past success with developing physician scientists from diverse backgrounds, will reveal a strong pipeline of candidates, and will describe expert faculty mentors that will broaden our approach to innovation with Anesthesiology.

PI_NAMEs: FREED, JULIE K (contact);HOGAN, QUINN H

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Anesthesiology;Science;Training

PROJECT_TITLE: Specialized Training in Anesthesiology Team Science


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: MINNEAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposed research will advance our fundamental understanding of G protein-coupled receptor (GPCR) signaling and unconventional myosin function in cells. Insights gained from research into GPCR signaling can be used to identify new drugs that selectively target GPCRs in diseases such as heart failure, neuropsychiatric disorders, and diabetes. Research into the molecular basis of myosin motility in cells will pave the way to understand the disease mechanisms that stem from deregulated myosin function.

PI_NAMEs: SIVARAMAKRISHNAN, SIVARAJ  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;Binding;Biochemical;Biological Assay;Biological Products;Biomimetics;Biophysics;Biosensor;Cell membrane;Cell Physiology;Cell Surface Receptors;Cells;Cellular biology;Chimera organism;Collaborations;combat;Communication;Coupling;Crowding;Cytoskeleton;cytosolic receptor;Diabetes Mellitus;Disease;Engineering;experimental study;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;genetic approach;GTP-Binding Proteins;Heart failure;Homeostasis;innovation;insight;Integrins;Kinetics;LDL-Receptor Related Protein 2;Ligands;MAP Kinase Gene;Maps;Measures;Mechanics;Mediating;Membrane Protein Traffic;Molecular;Molecular Conformation;Motility;Motor;Motor Activity;Myosin ATPase;nanobodies;neuropsychiatric disorder;new technology;novel;novel therapeutic intervention;novel therapeutics;optogenetics;Pathway interactions;Peptides;peptidomimetics;Permeability;plexin;programs;Protein Engineering;Protein Isoforms;protein protein interaction;receptor;Receptor Activation;Regulation;Research;Research Project Grants;Role;scaffold;Second Messenger Systems;Shapes;Signal Transduction;stem;Structure;Tail;Technology;trafficking

PROJECT_TITLE: Emergent cellular functions of GPCRs and myosins


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Pediatric

PI_NAMEs: PENROD-MARTIN, RACHEL  (contact)

PROJECT_TERMS: Address;Adult;Animal Model;Animal Technicians;Animals;Anxiety;Behavior;Behavior assessment;behavior test;Behavioral;behavioral phenotyping;Biological Assay;Breeding;Centers of Research Excellence;Child;Communication;Communities;conditioned fear;Consultations;Darkness;Data;Data Analyses;design;Disease;Distress;Electroencephalography;empowerment;Environment;Equilibrium;Equipment;Etiology;experience;experimental study;Family;forced swim test;Fright;Functional disorder;Funding;Genetic Models;Genotype;Goals;Grant;Human;Impulsivity;Individual;Infrastructure;interest;Leadership;Learning;Light;long term memory;Manuscripts;Marble;Measures;member;Memory;Mentors;Methods;Modeling;Modernization;Monitor;Moods;Morbidity - disease rate;Motor;mouse genetics;mouse model;Mus;neurodevelopment;Neurodevelopmental Disorder;Output;Patients;peer;peer coaching;Phenotype;Physiological;preference;Preparation;Procedures;programs;Protocols documentation;pup;Reaction Time;Reproducibility;Research;Research Design;Research Personnel;Resources;Running;Scheme;Seizures;Self Administration;skills;Sleep;social;Social Interaction;Standardization;stereotypy;Structure;Sucrose;Symptoms;Technical Expertise;Technology;Telemetry;Test Result;Testing;Training;Translational Research;Tube;United States National Institutes of Health;Variant

PROJECT_TITLE: Mouse Behavior Phenotyping Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: Newark

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Health Relevance After DNA damage, the fate for a cell to die or to survive with a stable or an altered genome, is a critical determinant for tumor development and therapeutic outcomes. This study aims to investigate the mechanisms by which Ku70 methylation regulates DNA repair and cell fate through apoptosis. It will contribute to new in- depth understanding of the cause and therapeutic outcomes of cancer.

PI_NAMEs: SHEN, ZHIYUAN  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acetylation;Acinus organ component;Actins;Affect;Alleles;Animal Model;Antibodies;antibody detection;Apoptosis;Apoptotic;BAX gene;Bax protein;Binding;Biochemistry;C-terminal;Cell Nucleus;Cells;Cellular biology;Chromatin;Cytoplasm;Development;dimer;Dimerization;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Elements;Ensure;Enzymes;Epitopes;Event;Excision;G22P1 gene;Genome;Goals;Health;Histidine;Histones;Human;Human Genome;in vivo;Induction of Apoptosis;Ionizing radiation;irradiation;Knock-in Mouse;Ku70 protein;LoxP-flanked allele;Lysine;Malignant Neoplasms;Measures;Mediating;methyl group;Methylation;Methyltransferase;Mitochondria;Modeling;Molecular;Molecular Biology;Molecular Conformation;monomer;mouse genetics;Mus;non-histone protein;Nonhomologous DNA End Joining;novel;Nuclear;overexpression;Oxygenases;Plants;Play;Positioning Attribute;Proteins;Reagent;recruit;Regulation;response;restraint;ribulose-1,5-bisphosphate;Ribulose-Bisphosphate Carboxylase;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;SET Domain;Side;Signal Transduction;Site;success;Tertiary Protein Structure;Testing;therapy outcome;Time;tumor;tumorigenesis;XRCC5 gene

PROJECT_TITLE: Regulation of Ku70 methylation and functions by SETD4

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Congenital Structural Anomalies;Fragile X Syndrome;Genetics;Hearing Loss;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: WILKERSON, BRENT ALLEN (contact)

PROJECT_TERMS: Acoustics;Address;Age;Animal Model;Anxiety;audiogenic seizure;Auditory;Auditory Brainstem Responses;Auditory Perceptual Disorders;Auditory system;autism spectrum disorder;autism symptoms;Behavior;Behavioral;Bioinformatics;Biometry;Blood Vessels;Candidate Disease Gene;career development;cell type;Cells;Centers for Disease Control and Prevention (U.S.);Centers of Research Excellence;Characteristics;Child;Cochlea;cochlear development;Code;Communication;Communication difficulty;Complex;Craniofacial Abnormalities;Data;Data Set;Defect;Development;Disease;Epithelial Cells;Etiology;Fibroblasts;Flatfoot;FMR1 gene;Fragile X Syndrome;Functional disorder;Funding;Future;Gene Expression Profile;gene network;Generations;Genetic;Genotype;Goals;Hair Cells;Hearing;hearing impairment;Hearing problem;Heterozygote;Hyperactivity;Hyperacusis;Immune;Impaired cognition;in vivo imaging;inner ear development;innovation;insight;Interdisciplinary Study;Knockout Mice;Labyrinth;Language;Language Delays;Lateral;Macrophage;malformation;Maps;Measurable;Mediating;Mentors;Mentorship;Mesenchymal;Methods;Molecular;mouse model;multidisciplinary;Mus;Neonatal;neural;neurobehavioral;neurodevelopment;Neuroglia;Neurons;Pathogenesis;Pathway Analysis;Peripheral;Phenotype;preference;Process;Regulation;repetitive behavior;Research;research study;Resources;restoration;Risk Factors;risk variant;RNA;Role;Seizures;Sensorineural Hearing Loss;Sensory;Sensory Hair;single nucleus RNA-sequencing;single-cell RNA sequencing;social;social communication;sound;Startle Reaction;Stria Vascularis;Study models;success;Supporting Cell;Symptoms;synaptogenesis;Testing;Testis;Therapeutic;therapeutic gene;Therapeutic Intervention;Tissues;tool;Training;transcriptomics;Ultrasonics;vector control;Viral;vocalization;young adult

PROJECT_TITLE: Project 2: Wilkerson


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lymphatic Research

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Most cancers spread first to lymph nodes and later to distant tissues. We recently discovered that cancer cells in lymph nodes cause immune cells there to help the cancer spread throughout the body. In this project, we will use new technologies to identify the genes and molecules responsible for this process and investigate new therapies to overcome it.

PI_NAMEs: ENGLEMAN, EDGAR G.  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: adaptive immune response;Adoptive Transfer;analytical tool;antibody conjugate;Antigen Presentation;Antigen-Presenting Cells;ATAC-seq;Atypical lymphocyte;Binding Sites;bisulfite sequencing;cancer cell;Cell Line;Cells;Cessation of life;Chromatin;Combined Modality Therapy;Cytometry;Data Set;Distant;Distant Metastasis;Drainage procedure;Education;Epigenetic Process;epigenetic regulation;Exhibits;Gene Expression Profile;Genes;Genetic;Goals;Histone Deacetylase Inhibitor;Human;human data;human tissue;Immune;Immune Evasion;Immune system;Immune Tolerance;Immunosuppression;Immunotherapeutic agent;Leukocytes;Liver;Lung;lymph nodes;Lymphatic;Lymphocyte;Malignant - descriptor;malignant lymphocyte;Malignant Neoplasms;Melanoma;Metastasis Induction;Metastatic Neoplasm to Lymph Nodes;Methods;Microscopy;Modeling;Molecular;mouse model;multidimensional data;Neoplasm Metastasis;neoplastic cell;new technology;novel;novel therapeutics;Organ;Organism;Pancreatic Ductal Adenocarcinoma;Population;prevent;Process;programs;Research Design;Research Personnel;Resolution;Role;single cell ATAC-seq;Site;System;T cell receptor repertoire sequencing;T-Cell Antigen Receptor Specificity;T-Lymphocyte;Therapeutic;Tissues;transcription factor;tumor;Tumor Antigens;tumor heterogeneity;tumor progression;Work

PROJECT_TITLE: Targeting Lymph Node Dependent Immune Tolerance in Cancer

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: NEW YORK

ORG_DEPT: CHEMISTRY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: Project Narrative One of the most significant barriers to health-related research involving small molecules is the rapid assembly of therapeutic agents. This proposal seeks to develop new methods to synthesize complex frameworks using easily accessible precursors with high efficiency.

PI_NAMEs: ROVIS, TOMISLAV  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Alkenes;Alkylation;Amides;Amines;aryl halide;Automobile Driving;Carboxylic Acids;Catalysis;catalyst;Chemistry;chlorination;Cobalt;Complex;Copper;Coupling;dehydrogenation;design;Distal;Drug Design;drug discovery;efficacious treatment;FDA approved;functional group;Funding;Goals;Health;human disease;Hydrogen Bonding;Imines;interest;Metals;Methods;Nickel;Nitrogen;Oxidation-Reduction;Pharmaceutical Preparations;Pharmacologic Substance;Planet Earth;Positioning Attribute;Principal Investigator;programs;Protocols documentation;Reaction;Research;Salts;scaffold;Site;small molecule;Sodium Chloride;success;Sulfhydryl Compounds;System;tertiary amine;Therapeutic Agents;Uncertainty;Work

PROJECT_TITLE: Selective Functionalization of Aliphatic Amines

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Unintentional Childhood Injury

PI_NAMEs: ALBAYRAM, ONDER  (contact)

PROJECT_TERMS: Adolescence;Adult;Affect;Applications Grants;Area;associated symptom;Behavioral;behavioral impairment;Brain;brain cell;Brain Injuries;career development;CD11c Antigens;cell type;Cells;Centers of Research Excellence;Cerebral Palsy;Chronic;clinically relevant;Cognitive;Complement;Complement 3a;Complement Activation;Complement Receptor;Data;Data Set;Development;Disease;Ensure;Failure;fetal;Functional disorder;Future;Goals;Hemorrhage;Hydrocephalus;Immune;immune activation;Immunologic Memory;Infiltration;Injury;innovation;intraventricular hemorrhage;ITGAM gene;ITGAX gene;ITGB2 gene;Knockout Mice;Knowledge;Life;Ligands;Link;Macrophage-1 Antigen;Mediating;Medical;Mentors;Microglia;Modeling;mouse model;Mus;Neonatal;neonatal brain;Neonatal Brain Injury;neonate;Nerve Degeneration;neurobehavioral;neurodevelopment;Neurodevelopmental Deficit;Neurodevelopmental Disorder;Neurodevelopmental Impairment;Neuroimmune;neuroinflammation;Neurons;novel;Opsonin;Pathogenicity;Pathologic Processes;Perinatal subependymal hemorrhage;Periventricular Leukomalacia;Phagocytosis;pharmacologic;Phase;Phenotype;preterm newborn;Process;receptor;Research Personnel;Research Support;Resources;response;Risk;Risk Factors;Risk Reduction;Role;Signal Transduction;Site;Subependymal;success;Symptoms;Synapses;Testing;Therapeutic;Time;tool;Training;United States National Institutes of Health;uptake;Vascularization

PROJECT_TITLE: Project 3: Albayram


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Complementary and Integrative Health;Heart Disease;Nutrition;Obesity;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Cardiovascular disease remains the number one cause of death globally, and > 70% of cases can be attributed to cardiometabolic risk factors. The new research proposed in this program will evaluate cardiometabolic risk factors among diverse patient populations by leveraging new technological advances in precision medicine. Dr, Mora is a nationally recognized leader in patient-oriented cardiovascular prevention research, education, and mentoring. Her research and mentoring opportunities are enabled by the availability and recruitment of outstanding junior investigators, the strong multidisciplinary backgrounds of her collaborations, and the depth and breadth of resources at the Brigham and Women's Hospital, Harvard Medical School, the Harvard T,H, Chan School of Public Health, and multiple nearby Boston teaching hospitals and academic institutions, providing rich mentoring opportunities to train the next-generation of cardiovascular researchers.

PI_NAMEs: MORA, SAMIA  (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Achievement;Acute-Phase Proteins;Address;Adult;Age;aged;Atherosclerosis;atherosclerosis risk;Award;Biological Markers;Body mass index;Boston;Branched-Chain Amino Acids;C-Peptide;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;career development;case control;Cause of Death;Cessation of life;Classification;Clinical;clinical practice;clinical risk;Collaborations;coronary event;Coronary heart disease;cost effective;Coupling;Data;Death Rate;Diabetes Mellitus;Diagnostic;Diet;disorder risk;Dual-Energy X-Ray Absorptiometry;Education;Environment;Epidemiology;ethnic difference;Ethnic Origin;Event;experience;Faculty;follow-up;Future;glycosylation;Goals;Guidelines;Health;health record;Healthcare;high risk;Hospitals;Impairment;improved;Individual;inflammatory marker;innovation;Institution;Insulin;Insulin Resistance;interest;International;Intervention;Investigation;Life Style;Lipids;Lipoprotein (a);Long-Term Effects;Measurement;Measures;medical schools;men;Mentors;Metabolic syndrome;Metabolism;metabolomics;Mid-Career Clinical Scientist Award (K24);Modification;Molecular;Molecular Epidemiology;mortality;multidisciplinary;new technology;next generation;novel;Nuclear Magnetic Resonance;Obesity;Omega-3 Fatty Acids;Onset of illness;Outcome;Overweight;patient oriented;patient oriented research;patient population;Patients;Physical activity;Plasma;Postdoctoral Fellow;precision medicine;premature;prevent;Prevention;Prevention Research;Preventive measure;Preventive therapy;programs;Public Health;Public Health Schools;Random Allocation;Recommendation;recruit;Recurrence;Research;Research Personnel;Research Project Grants;research study;Resources;Risk;Risk Factors;risk stratification;Sampling;screening;sex;Smoking;South Asian;Teaching Hospitals;Technology;Testing;therapeutic target;Training;translational applications;United Arab Emirates;Vitamin D;waist circumference;Woman;Work

PROJECT_TITLE: Mentored Patient-Oriented Research for Preventing ASCVD Events

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: DK

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative This study will contribute to identify the main risk factors that put children at risk of developing YT2D. The study will shed light on the factors that explain health disparities in YT2D.

PI_NAMEs: ISASI, CARMEN R. (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: Accelerometer;Adult;Ancillary Study;Behavioral;Beta Cell;biobank;Biological Factors;Biological Specimen Banks;Cell Physiology;Child;Child Health Services;Childhood;Clinical;cohort;Communities;community partners;community-level factor;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Country;County;Data;Development;Diabetes Mellitus;diabetes risk;Dietary Assessment;Disease;Disease Progression;Disparity;Economics;Eligibility Determination;Enrollment;ethnic disparity;ethnic diversity;ethnic minority;Ethnic Origin;Family;follow up assessment;food insecurity;Foundations;Functional disorder;Future;Glucose;glucose tolerance;glycemic control;health disparity;high risk;Individual;Inequity;Infrastructure;Joints;Knowledge;lifestyle factors;low socioeconomic status;Machine Learning;Medical;Medical center;Metabolic;Metabolic Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Obesity Epidemic;OGTT;Overweight;Pediatric Hospitals;Physical activity;Physiological;Population;Positioning Attribute;Prediabetes syndrome;Prevention;Prevention strategy;primary care practice;primary outcome;Process;protocol development;Protocols documentation;Provider;Public Health;Publications;Questionnaires;Race;racial disparity;racial diversity;racial minority;recruit;Research Design;response;Risk;Risk Factors;risk prediction model;secondary endpoint;Shapes;Site;Sleep;social;social determinants;social health determinants;sociocultural determinant;socioeconomic disparity;Socioeconomic Status;Techniques;Testing;Translations;treatment strategy;working group;Youth

PROJECT_TITLE: Metabolic, behavioral and social determinants of youth-onset T2D


NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Pediatric;Rural Health

ORG_CITY: GAINESVILLE

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Program Director/Principal Investigator (Last, First, Middle): Fishe, Jennifer, N Project Narrative This pilot cluster randomized controlled trial of EMS-administered CS for pediatric asthma patients will help fill a knowledge gap in the EMS treatment of this common pediatric emergency condition. This study innovatively combines clinical, economic, and geospatial analysis to see how EMS-administered CS affects patient outcomes, healthcare costs, and EMS operations. That novel combination of analyses lays the foundation for developing adaptable pediatric asthma guidelines for implementation by diverse EMS agencies nationwide as part of a future multicenter trial. PHS 398/2590 (Rev. 06/09) Page 1 Continuation Format Page

PI_NAMEs: FISHE, JENNIFER NOEL (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Accident and Emergency department;Admission activity;Adopted;Adoption;Adrenal Cortex Hormones;Adult;Affect;Age;Agreement;Ambulances;Antiinflammatory Effect;Asthma;asthma exacerbation;asthmatic patient;Biometry;Budgets;career development;Caring;Charge;Child;Childhood;Childhood Asthma;Chronic Disease;Clinical;Clinical Trials;common treatment;cost;County;Critical Illness;Data;design;Development;Economics;Emergency department visit;Emergency medical service;Enrollment;Environment;evidence base;experience;Florida;Foundations;Funding;Future;Geographic Information Systems;Goals;Grant;Guidelines;Health Care Costs;hospital admission rate;Hospitalization;Hospitals;Hour;human subject protection;improved;improved outcome;information system analysis;innovation;Intensive Care Units;Intravenous;K-Series Research Career Programs;Knowledge;Leadership;Length of Stay;Master of Science;Medical emergency;Mentors;Mentorship;Methylprednisolone;Modeling;Multicenter Trials;multidisciplinary;novel;operation;Oral;Oral Administration;Outcome;Patient-Focused Outcomes;Patients;pediatric emergency;Physicians;Pilot Projects;Positioning Attribute;prednisolone;primary outcome;Principal Investigator;programs;prospective;Protocols documentation;Randomized;Randomized, Controlled Trials;receptor;Recommendation;Research;Research Personnel;Rural;rural area;secondary outcome;service providers;Steroids;Structure;suburb;Tablets;Testing;Time;time use;Training;Translating;Treatment Failure;treatment services;trial design;underserved rural area;Up-Regulation;Update

PROJECT_TITLE: Early Administration of Steroids in the Ambulance Setting: An Observational Design Trial


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: BERTO, STEFANO  (contact)

PROJECT_TERMS: Affect;Age;Alleles;Animal Model;Animals;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavioral;behavioral phenotyping;Bioinformatics;Biological Models;Biological Process;Brain;career development;Cell Adhesion Molecules;Cell model;Centers of Research Excellence;Child;Cognition;CRISPR/Cas technology;Data;density;Development;Disease;disorder risk;Electroencephalography;Electrophysiology (science);Environment;Epilepsy;Episodic memory;excitatory neuron;Face;Family;Frequencies;Future;Generations;Genes;Genetic Transcription;Genomics;hearing impairment;HLA Antigens;Human;human induced pluripotent stem cells;human subject;Image;Impaired cognition;innovation;Intellectual functioning disability;Interleukin Receptor;Interleukin-1;Investigation;Knockout Mice;Link;loss of function;loss of function mutation;Measures;Memory;Messenger RNA;Mission;Molecular;motor impairment;mouse model;multidisciplinary;Mutation;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;neuronal excitability;Neurons;neurotransmitter release;novel;paralogous gene;Pattern;Phenotype;Play;programs;Protein Tyrosine Phosphatase;PTPRR gene;Publishing;receptor;Regulation;Research Personnel;Resources;Risk;risk variant;Role;Short-Term Memory;Signal Pathway;single nucleus RNA-sequencing;social;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;synaptogenesis;Testing;transcriptomics;United States;United States National Institutes of Health;Vertebral column;Visual

PROJECT_TITLE: Project 4: Berto


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Lung;Lung Cancer;Pancreatic Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative: Plasma membrane-anchored KRAS small GTPase selectively interacts with distinct phosphatidylserine (PS) species with mixed-chain acyl chains in the regulation of cell proliferation of normal or tumor cells. We propose to investigate how remodeling PS acyl chain profile, by lysophosphatidylcholine acyltransferase 1 (LPCAT1) and LPCAT4, modulates KRAS nanoclustering and function. Because of the key roles of KRAS in human cancer, our new findings allow us to better appreciate how lipid acyl chain profile contributes to cancer biology.

PI_NAMEs: ZHOU, YONG  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Acute;Acyl Coenzyme A;Acyltransferase;Back;Binding;Biological;Biological Models;Caenorhabditis elegans;Cancer Biology;Cancer Patient;Cell membrane;Cell Physiology;Cell Proliferation;Cell Proliferation Regulation;Cells;cohort;Colorectal Neoplasms;Data;Diameter;Drug Targeting;Human;Impairment;improved;in vivo;KRAS oncogenesis;KRAS2 gene;Lecithin;Lipid Bilayers;lipidome;lipidomics;Lipids;Lung Neoplasms;Lysophosphatidylcholines;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;member;Membrane;Membrane Microdomains;Mitogen-Activated Protein Kinases;Modeling;Molecular;Molecular Conformation;Monomeric GTP-Binding Proteins;Mutate;Mutation;nanocluster;neoplastic cell;Normal Cell;novel;overexpression;Pancreas;pancreatic cancer cells;pancreatic neoplasm;Pathology;Patients;Phase;Phosphatidylserines;Plasma Cells;Probability;Proliferating;Property;Protein Isoforms;Proteins;RAS genes;recruit;Role;Sampling;segregation;Signal Transduction;Site;Solid;Sorting;Spatial Distribution;spatiotemporal;Specificity;Structure;Testing;Transmembrane Transport;tumor;Xenograft Model

PROJECT_TITLE: Phosphatidylserine acyl chain remodeling regulates KRAS spatial distribution and function on the plasma membrane.


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: This proposal represents an interdisciplinary and collaborative effort between dental and medical experts, towards improving outcomes for PLWH by proposing a prospective study for the identification of oral-systemic non-AIDS- associated comorbid diseases (NCDs) in a large population of HIV individuals, who have been on ART for at least one year. Results from our study will lead to a better understanding of key oral health manifestations among PLWH and their impact on the development and severity of NCDs. In addition, better understanding the interplay of oral and systemic inflammation in PLWH on long-term ART has the potential to improve oral and systemic outcomes and inform clinicians on novel interdisciplinary approaches (e.g. oral- systemic-connection) of reducing inflammation among PLWH.

PI_NAMEs: OMOLEHINWA, TEMITOPE T (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;aging related;Anti-Retroviral Agents;antiretroviral therapy;Automobile Driving;Biological Response Modifiers;Candidiasis;Cardiovascular Diseases;Caring;Cells;Cessation of life;chemokine;Chronic;Chronic Disease;Clinic;co-infection;Coagulation Process;cohort;Combined Modality Therapy;comorbidity;Complex;cytokine;Cytokine Activation;Data;Dental;Dental caries;Deterioration;Development;Diabetes Mellitus;Disease;Dyslipidemias;Environment;Functional disorder;Gingiva;Goals;Health;Health Status;Healthcare;Highly Active Antiretroviral Therapy;HIV;HIV diagnosis;HIV Infections;Hyperlipidemia;Immune;immune activation;immune function;improved;improved outcome;Individual;Infection;Inflammation;Inflammatory;Insulin Resistance;interdisciplinary approach;Knowledge;Link;Mediating;Mediator;Medical;Medicine;Metabolic;Metabolism;microbial;Mouth Diseases;neurocognitive disorder;novel;novel strategies;Oral;Oral cavity;Oral health;Osteoporosis;Outcome;Parotid Gland;Pathogenicity;Patient Admission;Patient-Focused Outcomes;Patients;Periodontal Diseases;Periodontitis;Persons;Pharmaceutical Preparations;Play;Population;Prevalence;Prevention;Prevention strategy;Prognosis;prospective;Prospective Studies;Reporting;Research;Research Design;response;Risk;Role;Saliva;saliva composition;Salivary;Salivary Glands;Salivary Proteins;Severities;side effect;Source;success;Systemic disease;systemic inflammatory response;Tissues;treatment guidelines;treatment response;Viral;Virus Replication;Xerostomia

PROJECT_TITLE: The Impact of Oral Health on Metabolism and Persistent Inflammation in HIV Patients on Antiretroviral Therapy (OHART)


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Precision Medicine;Urologic Diseases

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE SRD5A2 is a critical enzyme for prostatic development and growth, and the SRD5A2 inhibitor, finasteride, is commonly used to treat benign prostatic hyperplasia (BPH). SRD5A2 is absent in 30% of normal adult men, which explains the resistance of a subset of patients to finasteride and other BPH therapies. This project assesses utilization of SR5A2 as a marker to identify patients who may be resistant to 5-alpha reductase inhibitor therapy for management of BPH.

PI_NAMEs: OLUMI, ARIA F (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: 5 Alpha-Reductase Inhibitor;Accounting;Adult;Affect;Age;androgenic;Androgens;bench to bedside;Benign Prostatic Hypertrophy;Binding;Biological Assay;Bladder;Blood specimen;blood-based biomarker;Clinical;clinically significant;Collaborations;cost;Development;Disease;DNA;DNA Binding;Drug usage;Enrollment;Enzymes;Epigenetic Process;Epithelial Cells;Equilibrium;Estradiol;estrogenic;Estrogens;ferumoxytol;Finasteride;Frequencies;Gene Silencing;genetic signature;Goals;Growth;Growth and Development function;Healthcare Systems;Hormonal;Hormones;Human;Hypermethylation;Individual;Inflammation;Inflammation Mediators;inhibitor;inhibitor therapy;Interleukin-6;Investigation;Laboratory Finding;lower urinary tract symptoms;Magnetic Resonance Imaging;male;Medical;men;Methylation;Modification;nanoparticle;NF-kappa B;Obesity;Obstruction;Oxidoreductase;Pathway interactions;patient stratification;patient subsets;Patients;Pharmaceutical Preparations;precision medicine;predictive marker;promoter;Promoter Regions;prospective;Prostate;Prostatic;Prostatic Tissue;protein expression;Proteins;Quality of life;Resistance;Resistance development;resistance mechanism;Resources;risk stratification;Role;Secondary to;Serum;SRD5A2 gene;Steroids;Stromal Cells;Techniques;Technology;Testosterone;Testosterone 5-alpha-Reductase;Time;Tissues;TNF gene;Transferase;Translating;Work;years of life lost

PROJECT_TITLE: SRD5A2 as a Marker of Resistance to 5ARI Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse;Women's Health Research

ORG_CITY: MIAMI

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: PROJECT NARRATIVE The opioid crisis has escalated dramatically among women, but women face many unique challenges in obtaining treatment for opioid use disorder (OUD), highlighting the importance of women-centered strategies for engagement in care. To address these gendered needs and barriers to care, we propose a novel women- centered recovery navigation system. The proposed research will 1) identify key barriers to engagement in care for women with OUD, as well as potential solutions; 2) develop and evaluate a pilot women-centered recovery navigator program; and 3) develop and evaluate a web-based recovery platform to engage women with OUD in care.

PI_NAMEs: WARD, MELISSA KARI (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Accounting;addiction;Address;American;Award;Awareness;barrier to care;care seeking;Caring;Child;Child Custody;Chronic;Clinical;community engaged intervention;community engaged research;community led intervention;comorbidity;COVID-19;Data;Development;Disparity;evidence base;Evidence based intervention;Evidence based program;experience;Face;Family member;Female;Focus Groups;Gender;gender difference;Goals;Health;Health Personnel;Health Services Accessibility;HIV;Hybrids;improved;improved outcome;Intervention;Interview;K-Series Research Career Programs;Life Cycle Stages;medical complication;meetings;men;Mental Health;Mentorship;Methods;Navigation System;Neonatal Abstinence Syndrome;Neurobiology;novel;Online Systems;Opiate Addiction;Opioid;opioid epidemic;opioid overdose;opioid use;opioid use disorder;Outcome;Participant;patient navigator;Persons;Population;Positioning Attribute;post pregnancy;Pregnancy;programs;prototype;public health emergency;Randomized;Recovery;Research;Research Personnel;Resources;scale up;Services;Shame;social stigma;Structure;Surveys;theories;therapy design;therapy development;usability;virtual;Vulnerable Populations;web platform;web-based tool;Woman;women's outcomes

PROJECT_TITLE: The Women-Centered Opioid Recovery Project: Advancing women's engagement in care for opioid use disorder through development of a novel recovery navigation system led by women in recovery

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Mental Health;Mental Illness;Prevention;Social Determinants of Health

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE The relationship between migration and mental health is complex given the heterogeneous and context specific nature of migration and, generally speaking, forcibly displaced populations are at increased risk for developing mental health disorders. Yet, despite the recent Venezuelan forced displacement being the greatest diaspora in the recorded history of Latin America, little is known about the mental health effects and potential treatment targets for this at risk, stigmatized, and underserved population. In order to address a significant lack of mental health care seeking and retention in this population, the current multi-disciplinary study proposes a comprehensive examination of factors that serve as facilitators and barriers to mental health treatment seeking and treatment retention in forcibly displaced populations, which will then be leveraged to adapt and pilot an evidence-based treatment approach to increase retention of Venezuelan migrants in care.

PI_NAMEs: CARROLL, HALEY  (contact)

PROGRAM_OFFICER_NAME: CAMPBELL-ROSEN, HOLLY RENEE

PROJECT_TERMS: Address;Affect;Aftercare;Anxiety;Area;Attitude;Behavior Therapy;Belief;Birds;burden of illness;care seeking;career;career development;Caring;Characteristics;Child Care;Client;climate change;Clinical;Clinical Management;Collaborations;Communities;Complex;Conflict (Psychology);COVID-19;Crime;design;Diagnostic;displaced person;Elements;Enabling Factors;Environment;Evidence based treatment;experience;Focus Groups;follow-up;food shortage;Freedom;Goals;Health system;help-seeking behavior;implementation science;improved;Influentials;information gathering;Interdisciplinary Study;International Migrations;Intervention;Intervention Studies;Intervention Trial;Interview;Knowledge;Label;Language;Latin America;Life;marginalized population;member;Mental Depression;Mental disorders;Mental Health;Mental Health Associations;Mental Health Services;Mentors;Mentorship;Migrant;migration;Modeling;multidisciplinary;National Institute of Mental Health;Nature;Outcome;Perception;Persons;Peru;pilot trial;Politics;Population;Population Growth;Post-Traumatic Stress Disorders;Poverty;Predisposing Factor;Prevalence;Problem Solving;Professional counselor;programs;Protocols documentation;Provider;psychoeducation;Public Health;Qualitative Methods;Qualitative Research;Randomized;Recording of previous events;recruit;Reinforcing Factor;Research;Research Personnel;Research Support;Risk;Risk Factors;Scientist;Services;skills;social stigma;Social support;Stigmatization;Supervision;Target Populations;Testing;Thinking;Training;Training Activity;Treatment Protocols;Underserved Population;Venezuela;Venezuelan;Waiting Lists;Work

PROJECT_TITLE: Adaptation and assessment of a common element treatment protocol designed to improve mental health in forcibly displaced populations


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: TALLAHASSEE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: Project Narrative: Although we have a good idea of the risk factors for type II diabetes, the ultimate causes are not known at the molecular-level. This application focuses on achieving a molecular-level understanding of how the human-IAPP (islet amyloid polypeptide; also known as amylin) protein may attack the islet cells that produce insulin. Such molecular features are unique to human-IAPP, when compared to non-toxic rat-IAPP, indicating the need for a better understanding of the molecular processes underlying the pathology of type II diabetes. Therefore, the outcome of the proposed study will aid in the development of drugs to treat the disease.

PI_NAMEs: RAMAMOORTHY, AYYALUSAMY  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Acceleration;adduct;Affect;Affinity;aging related;Alzheimer's Disease;Amyloid;Amyloid fibers;amyloid formation;amyloidogenesis;Atomic Force Microscopy;Basic Science;Beta Cell;beta pleated sheet;Binding;biophysical techniques;Biophysics;Calcium;Cell Death;Cell membrane;Cell Nucleus;Cells;Cellular Membrane;Cessation of life;Characteristics;Chemicals;Clinical Research;Copper;cytotoxic;Degenerative Disorder;Deposition;design;Diabetes Mellitus;diabetic;diabetic patient;Disease;Disease Progression;drug development;experimental study;FDA approved;Fiber;Functional disorder;Genetic;glucose metabolism;Growth;Homeostasis;Hormone secretion;Human;Human Genome;Individual;inhibitor;insight;insoluble fiber;Insulin;Insulin Resistance;Investigation;islet amyloid polypeptide;Islet Cell;Kinetics;Link;Lipids;Maps;Measurement;Measures;Membrane;Membrane Lipids;Metal Binding Site;Metals;Minority;misfolded protein;Molecular;Molecular Chaperones;Monitor;Multidimensional NMR Techniques;mutant;Mutation;Names;nanodisc technology;nanodisk;Nature;NMR Spectroscopy;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Nuclear;Outcome;overexpression;Parkinson Disease;Pathologic;Pathology;Pathway interactions;Pattern;Play;Population;Pramlintide;Process;protein aggregation;Proteins;Rattus;Regulation;Resolution;Risk Factors;Role;Secretory Vesicles;solid state;solid state nuclear magnetic resonance;Speed;Structural Models;Structure;Survival Rate;Techniques;Testing;Time;Titrations;Toxic effect;Type 2 diabetic;Zinc

PROJECT_TITLE: Structural Investigation of Amylin Oligomers Associated to Type-2 Diabetes

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: ATLANTA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE  Functional magnetic resonance imaging is a popular tool in studies of neurodevelopmental disorders, but re- producibility is a major issue, in part due to biases and inefﬁciencies related to head motion during MRI collection. We develop statistical methods that account for issues created by head motion, and we propose a model for brain dynamics during a task. We conduct a reproducibility study to learn how the brain functions in autism spectrum disorder and develop tools that can be used by other research groups to improve our understanding of brain disorders.

PI_NAMEs: RISK, BENJAMIN BREWSTER (contact)

PROGRAM_OFFICER_NAME: WOUHIB, ABERA

PROJECT_TERMS: Address;autism spectrum disorder;autistic children;behavior measurement;Brain;Brain Diseases;Brain region;Child;Childhood;Clip;cohort;Collection;Data;Data Set;Development;Diagnosis;Education;Excision;Exclusion;experience;Family;Formulation;Functional Magnetic Resonance Imaging;Goals;Grant;Head;Impairment;improved;insight;Learning;Linear Models;Literature;Magnetic Resonance Imaging;Measures;Mediating;Mediation;Mental disorders;Mental Health;Methodology;Methods;Modeling;Morphologic artifacts;Motion;movie;Nervous System Disorder;neural;Neurodevelopmental Disorder;neuroimaging;Neurologic;novel;Participant;Probability;Quality Control;Reporting;Reproducibility;Research;Rest;Running;Sampling;Sampling Biases;Severities;Signal Transduction;Slide;Social Behavior;Social Interaction;software development;Statistical Methods;Testing;theories;therapy development;tool;Universities;visual tracking

PROJECT_TITLE: Statistical approaches to improving functional connectivity estimates with an application to autism

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences;Psychosis

ORG_CITY: DALLAS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Many human patients who suffer from Alzheimer's disease, dementia and the broad spectrum of psychosis, including schizophrenia, show a range of memory deficits along with the hippocampal-entorhinal cortex damage, yet little is known about how specific memories are accessed and formed into meaningful memories to accomplish given tasks, especially at the systems level. This proposed study focuses on the neural dynamics for successful memory access and retrieval during episodic working memory tasks to elucidate the neural circuit mechanism in the hippocampal-cortical network. Our proposed studies will uncover the neural dynamics of hippocampal-entorhinal memory system to extend our understanding of how the system malfunctions during psychotic states and to establish novel early-stage diagnostic measurements / analyses in human patients that are hinted by the animal in vivo recordings.

PI_NAMEs: YAMAMOTO, JUN  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Affect;Alzheimer's Disease;Animal Model;Animals;Area;awake;Behavior;Behavioral;Brain;Brain Diseases;Communication;Data;Dementia;Diagnostic;Dorsal;Electrophysiology (science);entorhinal cortex;Episodic memory;Event;experimental study;Fire - disasters;Future;Goals;Hippocampus;Human;in vivo;indexing;Link;Measurement;Memory;Memory impairment;memory process;memory retrieval;Modeling;Mus;neural;neural circuit;neuromechanism;Neurons;novel;optogenetics;Outcomes Research;Pathway interactions;Patients;Phase;Play;Population;Psychoses;psychotic;Research Proposals;Rest;Retrieval;Role;Running;Scheme;Schizophrenia;Short-Term Memory;Structure;success;System;Technology;Testing;theories;Time;Transgenic Mice;Work

PROJECT_TITLE: Neural Mechanism for Successful Memory Access in the Cortico-Hippocampal Networks

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Nanotechnology;Orphan Drug;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Despite recent advances in treatment, multiple myeloma (MM), the second most frequent human hematologic cancer remains incurable and there is an urgent need for novel and more effective therapies. MicroRNAs (miRs) play critical roles in the progression of MM-associated immune evasion and have an exciting potential for the development of novel and more effective therapies if they can efficiently be delivered in vivo. Here we propose to apply nanomedicine to study the role of miRs in MM biology and as therapeutic tools utilizing non-toxic polymeric nanoparticles (NPs) of proven in vivo miR targeting/delivering capacity to myeloma cells.

PI_NAMEs: CARRASCO, RUBEN D (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Adhesions;advanced disease;angiogenesis;Antisense Oligonucleotide Therapy;Apoptosis;BCL9 gene;Biochemical;Biology;Blood;bone cell;Bone Marrow;Bone Marrow Cells;Bortezomib;cancer therapy;cancer type;Cell Death;cell growth;Cell Line;Cell membrane;Cell Physiology;Cell Proliferation;Cell secretion;Cell surface;Cell Survival;Cells;Cellular biology;cellular targeting;Chemicals;chemokine;clinically relevant;Complex;Data;design;Development;Dexamethasone;Drug resistance;drug resistance development;Educational workshop;effective therapy;efficacious treatment;Encapsulated;Endothelial Cells;Engineering;Engraftment;Family;Formulation;Genetic Transcription;Goals;Growth;Hematologic Neoplasms;Histologic;Human;Immune;Immune Evasion;Immunocompetent;Immunocompromised Host;Immunologic Markers;Immunology;improved;In Vitro;in vitro activity;in vivo;in vivo evaluation;Individual;Inhibition of Apoptosis;innovation;lenalidomide;Libraries;Lymphocyte Subset;macromolecule;Macrophage;Malignant Neoplasms;Mediating;Methods;MicroRNAs;migration;Modality;Modeling;Multiple Myeloma;Mus;nanomedicine;nanoparticle;nanopolymer;Nanotechnology;National Cancer Institute;Natural Immunity;novel;novel therapeutics;Oncogenes;Oncogenic;Organ;overexpression;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Plasma Cells;Play;Polymers;preservation;Proliferating;Proteomics;Public Health;Recommendation;Refractory Disease;Regulation;Replacement Therapy;Resistance;Role;Signaling Molecule;siRNA delivery;submicron;System;Testing;therapeutic miRNA;tool;Toxic effect;Transcription Coactivator;Treatment Cost;treatment response;tumor;Tumor Suppressor Proteins;United States;Work;Xenograft Model

PROJECT_TITLE: Development of microRNA (miR)-based cell-targeted polymeric nanoparticles for myeloma therapy

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Disorders;Depression;Drug Abuse (NIDA only);Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

PHR: PROJECT NARRATIVE The proposed studies will provide critical insight into the targets and mechanisms that underlie ketamine’s rapid and robust therapeutic benefits for cases of depression in which traditional antidepressants are ineffective. By delineating how modification of RNA encoding key neurotrophic proteins these studies may help to guide the optimization existing antidepressants and to design novel fast-acting pharmacotherapies for treatment resistant depression.

PI_NAMEs: SICILIANO, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Acute;Adjuvant Therapy;American;Anesthetics;Animal Model;antagonist;anti-depressive agents;antidepressant effect;Apoptotic;Autopsy;Behavioral;Biological;Brain;Brain-Derived Neurotrophic Factor;brain-derived neurotrophic factor precursor;Bypass;Cell Line;Cells;Chronic;Clinical;Data Set;demethylation;depressed patient;design;Development;Diagnosis;DNA Modification Process;dosage;Electrophysiology (science);Epigenetic Process;epitranscriptome;epitranscriptomics;fat mass and obesity-associated protein;functional outcomes;Genes;Genetic;Genetic Transcription;genome wide association study;Glutamates;Glycogen Synthase Kinase 3;Hippocampus;Hour;Human;human induced pluripotent stem cells;Image;Immunoprecipitation;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;insight;Investigation;Ketamine;Major Depressive Disorder;Mediating;Mental Depression;Metalloproteases;Methylation;Microelectrodes;Modification;Molecular;monoamine;multiple omics;Mus;N-Methyl-D-Aspartate Receptors;Nerve Growth Factors;neuronal growth;Neurons;neurotrophic factor;novel;novel therapeutics;Obesity;patch clamp;Pathogenesis;Patients;pharmacologic;Pharmacotherapy;Phosphorylation;Positioning Attribute;postsynaptic;Prediction of Response to Therapy;presynaptic;prevent;Process;protein expression;Proteins;Proteomics;Reader;reduce symptoms;Regulation;Reporting;response;restoration;Risk;RNA;RNA methylation;side effect;Signal Transduction;Single Nucleotide Polymorphism;Site;Stress;Structure;synaptogenesis;Testing;Therapeutic;Therapeutic Effect;Tissues;Transcription Process;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Translation Process Protein;Translations;Treatment Efficacy;treatment-resistant depression;Up-Regulation

PROJECT_TITLE: Epitranscriptomic mechanisms of the antidepressant response to ketamine in human neurons


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PHR: Narrative SAR441236 is a novel synthetic antibody that combines three different anti-HIV-1 specificities into a single molecule. Our study leverages samples from the phase I ACTG study of SAR441236 and investigates the mechanisms of its antiviral effects and the virus adaptation to this neutralization. We believe our approaches test previously unexplored hypotheses that are central to understand how, for the first time, trispecific bnAbs may be used as HIV therapeutics.

PI_NAMEs: KURITZKES, DANIEL R.;TSIBRIS, ATHE M. (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Affect;AIDS clinical trial group;Antibodies;Antibody Therapy;antigen binding;antiretroviral therapy;arm;Binding;Binding Sites;Biological;Biology;Blood;Cells;Clear Cell;Clinical;Cloning;Data;Dose;Drug Kinetics;Engineering;Evolution;first-in-human;follow-up;Genes;Genome;Glycoproteins;glycosylation;Goals;Heterogeneity;HIV;HIV Envelope Protein gp120;HIV-1;HIV-1 vaccine;Human;human study;humanized mouse;Immune;Immune response;in vivo;Individual;Infection;Infusion procedures;innovation;Kinetics;laboratory experiment;Length;Link;Macaca;Maps;mathematical methods;Membrane;Methods;Modeling;Molecular Virology;neutralizing antibody;next generation sequencing;nonhuman primate;novel;Participant;Peripheral Blood Mononuclear Cell;Persons;Phase;Phylogenetic Analysis;Plasma;Polysaccharides;Population;Population Dynamics;Predisposition;pressure;Proteins;Rectum;Resistance;response;RNA;Role;Safety;Sampling;Satellite Viruses;Sequence Analysis;simian human immunodeficiency virus;single molecule;Site;Specificity;Structure;Surface;synthetic antibodies;Techniques;Testing;Therapeutic;Time;Translating;trial design;Vaccine Research;Variant;Viral;Viral load measurement;Viral Physiology;Viremia;Virus

PROJECT_TITLE: HIV-1 dynamics and evolution during trispecific broadly neutralizing antibody therapy

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Genetics;Interstitial Cystitis;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE To advance our understanding of bladder dysfunction in type 1 diabetes (T1D), this project links existing information on diabetes severity from a large NIH study to new assessments of urinary symptoms and bladder dysfunction and urine specimens for gene expression analyses. This work will contribute comprehensive critical data to expand our knowledge about the natural history and molecular mechanisms of bladder dysfunction in T1D.

PI_NAMEs: SARMA, ARUNA V (contact);WESSELLS, HUNTER

PROJECT_TERMS: Achievement;Afferent Neurons;Amputation;Ancillary Study;Autonomic Dysfunction;autonomic neuropathy;Bladder;Bladder Dysfunction;Blindness;case control;Cells;Cessation of life;Clinical;Clinical Data;cohort;Complications of Diabetes Mellitus;Data;design;Detection;diabetes control;Diabetes Mellitus;diabetic;Disease;Disease remission;Epidemiology;Epithelium;Esthesia;Evaluation;experience;Face;follow-up;Frequencies;Functional disorder;Funding;Future;Gender;Gene Expression Profile;Gene Expression Profiling;Genetic Transcription;glycemic control;Glycosylated hemoglobin A;Goals;High Prevalence;Human;Hyperglycemia;Impaired cognition;incontinence symptom;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention;Knowledge;Laboratories;Link;lower urinary tract symptoms;Machine Learning;Measurement;Measures;mechanotransduction;Medical;member;men;Mental Depression;Metabolic;Modeling;Molecular;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;novel;Overactive Bladder;Participant;Pathogenesis;Pathway interactions;Patients;Pattern;Persons;Phenotype;Play;Population;predictive modeling;Prevention;Publications;Publishing;Quality of life;randomized trial;Research;Research Personnel;Residual state;Risk;Risk Factors;Running;Severities;Signal Transduction;Specimen;Symptoms;Systems Biology;Techniques;Testing;Time;transcriptome sequencing;transmission process;treatment strategy;trial enrollment;United States National Institutes of Health;urinary;Urinary Incontinence;Urine;urologic;Urologic Diseases;Urology;Urothelium;Variant;Woman;Work

PROJECT_TITLE: UroEDIC Bladder: Bladder Dysfunction in Type 1 Diabetes

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Emergency Care;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative In light of a growing body of evidence which suggests that prolonged duration CPR is a dynamic process, without universally optimal “one-size-fits-all” parameters, advanced methods of CPR individualization may be applied to optimize cardiac and cerebral perfusion for these patients. We propose to study the effects of machine learning and optimal control techniques within the context of CPR, thus creating a closed-loop CPR system that has been trained by pre-clinical data to modify CPR characteristics and optimize blood flow. Our preliminary studies suggest that machine learning and control algorithms can be successfully deployed in a preclinical model to adapt compression and decompression depth, increasing vital organ blood flow as compared to standard CPR techniques. If our hypotheses are verified, a gateway for the first human trials is open.

PI_NAMEs: YANNOPOULOS, DEMETRIS  (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Acute;algorithm training;Algorithms;American Heart Association;Animal Experiments;Applications Grants;Artificial Intelligence;Basic Science;Biofeedback;Blood flow;Carbon Dioxide;Cardiac;Cardiopulmonary Resuscitation;Cerebrum;Cessation of life;Characteristics;Chest wall structure;Choices and Control;Chronic;Circulation;clinic ready;Clinical;Clinical Trials;clinically relevant;Collaborations;Coronary Arteriosclerosis;Coronary heart disease;coronary perfusion;Data;Databases;Device or Instrument Development;Devices;E-learning;Early Mobilizations;Evaluation;experience;experimental study;Family suidae;Feedback;Frequencies;Future;Generations;Goals;hemodynamics;Hospitals;Hour;Human;improved;in vivo;indexing;innovation;Knowledge;Learning;Light;Linear Regressions;Machine Learning;machine learning algorithm;machine learning prediction algorithm;Measurement;Measures;Mechanics;Metabolic;Methods;Modeling;Near-Infrared Spectroscopy;neural network;Neurologic;Organ;out-of-hospital cardiac arrest;Outcome;Oxygen;Patients;Performance;Perfusion;Phase I Clinical Trials;porcine model;pre-clinical;Pre-Clinical Model;prediction algorithm;pressure;Process;prospective;Publishing;Recommendation;Research;Resuscitation;Survival Rate;System;Techniques;Testing;Time;time interval;Training;training data;United States;Validation;Ventricular Fibrillation;Ventricular Tachycardia;verification and validation

PROJECT_TITLE: Evaluation of artificial intelligence-controlled CPR to improve vital organ perfusion and survival during prolonged resuscitation

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Asthma;Clinical Research;Eczema / Atopic Dermatitis;Food Allergies;Lung;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Our proposal integrates a prospective early life observational study of children along with functional multilayered omics, and mechanistic studies.

PI_NAMEs: KHURANA HERSHEY, GURJIT K. (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Address;Affect;Allergic;Allergic Disease;Allergic rhinitis;Asthma;Atopic Dermatitis;atopy;Birth;Child;Childhood;Childhood Asthma;Chronic;Clinical;Clinical Research;Clinical Trials;cohort;Cohort Studies;Collection;comorbidity;Complex;Coupled;Data;Development;Disease;Disease Progression;dysbiosis;Educational workshop;Enrollment;Environmental Risk Factor;Epigenetic Process;Evaluation;experience;Food Hypersensitivity;Functional disorder;Funding;Genetic;Genomics;Goals;Human;Hypersensitivity;Immunologics;Inflammatory;Intervention;Leadership;Lesion;Life;Longitudinal cohort study;Medical center;National Institute of Allergy and Infectious Disease;Observational Study;Outcome;Pediatric Hospitals;peripheral blood;Phenotype;Physiological;Positioning Attribute;prospective;Prospective cohort;Prospective, cohort study;recruit;Regulatory Affairs;Reporting;Research;Research Infrastructure;Research Project Grants;respiratory;response;Sampling;Skin;skin barrier;skin disorder;skin microbiome;Subgroup;Systems Biology;Visit;Visual

PROJECT_TITLE: Atopic dermatitis: mechanisms of disease progression


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: We have discovered and characterized a novel structure, called α-sheet, which we believe to be common among the soluble oligomeric forms of multiple amyloid peptides and proteins, including Abeta associated with Alzheimer's Disease. We have designed small peptides to be complementary to this structure, and they inhibit fibril formation via selective binding of the toxic oligomeric form of Abeta. Here we propose to investigate the structure of the amyloid species during the process of amyloidogenesis using different forms of Abeta, and explore the nature of the oligomers in CSF and in more biologically relevant model systems.

PI_NAMEs: DAGGETT, VALERIE D (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta oligomer;Adopted;Affect;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;amyloid formation;amyloid peptide;Amyloid Proteins;amyloid structure;amyloidogenesis;Amyloidosis;Animal Model;Behavior;Binding;Biological;Biological Assay;Biological Models;Cell model;Cells;Cerebrospinal Fluid;Circular Dichroism;conformer;cytotoxicity;design;Electrophoresis;Electrophysiology (science);Event;experimental study;Heterogeneity;Human;Immobilization;In Vitro;in vivo;inhibitor;Libraries;Liquid substance;Maps;Measurement;Methodology;Methods;Microfluidics;Modeling;Molecular Conformation;molecular dynamics;Molecular Sieve Chromatography;Molecular Weight;Monitor;monomer;Mus;mutant;Nature;neuroblastoma cell;neuroinflammation;novel;novel strategies;Patients;Peptides;Preparation;Process;Property;protein data bank;Proteins;Reagent;Role;Sampling;simulation;Site;Spectrum Analysis;Standardization;Stretching;Structure;System;Technology;Toxic effect;Variant;Vertebral column;Work

PROJECT_TITLE: Conformational heterogeneity and alpha-sheet: Determinants of toxicity in Abeta variants

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS-R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Project narrative Homologous recombination and adaptive evolution are key mechanisms driving bacterial adaptation to new environments and new treatments. The proposed study aims to apply new approaches to determine the rates and patterns of recombination across genomic data in order to identify the factors shaping the rates and landscapes of recombination as well as the impact of adaptive evolution on bacteria. Upon completion, this project will provide a global view of the interplay between recombination and adaptative evolution across hundreds of bacterial species.

PI_NAMEs: BOBAY, LOUIS-MARIE  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Affect;Animals;Antibiotic Resistance;Architecture;Automobile Driving;Bacteria;Bacterial Chromosomes;Bacterial Genome;Bacterial Infections;Bayesian Analysis;Biology;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Contracts;Data Set;deep learning;DNA;Ecology;Elements;Environment;Epidemic;Evolution;Frequencies;gene conservation;Gene Conversion;gene function;Genes;Genetic Models;Genetic Recombination;Genome;genome analysis;genomic data;Genomics;Health;high throughput screening;homologous recombination;Hot Spot;Human;Individual;innovation;Knowledge;Laboratories;large datasets;Maps;Mediating;Methodology;Methods;microbial;Modeling;novel strategies;Organism;Pathogenicity;Pathway interactions;Pattern;Phenotype;Plants;Play;Population;Population Genetics;Population Sizes;Process;Prokaryotic Cells;Recombinants;resistance gene;Role;Sampling;Shapes;Spottings;Stress;Structure;Testing;Time;tool;trait;Variant;Virulence;virulence gene;Virulent;Work

PROJECT_TITLE: Investigating the Impact and Patterns of Homologous Recombination and Adaptive Evolution on Bacterial Genomes

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative  The major goal of this project is to improve the diagnostic, treatment guidance, and research utility of quantitative positron emission tomography (PET) imaging, through the development of robust, near real-time, deep-learning based reconstruction approaches allowing efficacious use of standard, low dose, and novel low activity imaging molecular bio-tracers. The proposed work is relevant to public health, since an improvement in the reconstructed images will lead to more accurate diagnosis of diseases and more accurate treatment guidance and monitoring of the response to therapy, while allowing for decreased patient radiation dose. It will also facilitate quantitatively reliable tools for research investigations with new radiotracers for PET tailored to specific diseases. 2

PI_NAMEs: MATEJ, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Address;Algorithms;Application procedure;Archives;Area;assessment application;Breast;breast imaging;Case Study;cellular imaging;chimeric antigen receptor T cells;Clinical;Clinical Data;clinical efficacy;clinically relevant;convolutional neural network;Data;data modeling;Dedications;deep learning;denoising;Detection;detector;Development;Diagnostic;Diagnostic Imaging;Discipline of Nuclear Medicine;Disease;disease diagnosis;Dose;efficacy evaluation;Evaluation;Explosion;Geometry;Goals;Half-Life;heart motion;Image;Imaging Techniques;improved;innovation;instrumentation;Intervention;Interventional Imaging;Investigation;Isotopes;Label;learning network;loss of function;Lung;Modeling;Modernization;molecular imaging;Monitor;Morphologic artifacts;Motion;neural network;neural network architecture;novel;novel strategies;Organ;Patients;Performance;personalized medicine;Physics;Positron;Positron-Emission Tomography;Procedures;Property;Protocols documentation;proton therapy;Psychological Transfer;Public Health;Radiation Dose Unit;radiotracer;reconstruction;Research;Resolution;response;Running;Scanning;solid state;statistics;success;System;Techniques;Testing;Time;tomography;tool;Tracer;Training;Training Technics;treatment response;Validation;Work

PROJECT_TITLE: Deep Learning Reconstruction for Improved TOF PET Using Histo-Image Partitioning

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The desire to consume alcohol is driven by motivation; it is commonly believed that this motivation is altered in those with substance use disorders. The central nucleus of the amygdala is one potential neural substrate for modulating action selection, both seeking and drinking, based on changes in motivation. The proposed research seeks to explore the neural activity pattern in the central nucleus of the amygdala during instrumental tasks rewarded with ethanol to gain a clearer picture of this region’s role in motivated behaviors.

PI_NAMEs: CASTRO, MATILDE  (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TITLE: Role of the central nucleus of the amygdala during ethanol-rewarded instrumental tasks


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Women in East and Southern Africa experience two-fold higher risk of HIV acquisition during pregnancy and face adherence challenges with existing biomedical prevention methods – daily oral pre-exposure prophylaxis (PrEP). This project leverages data from an ongoing R01 to evaluate pregnant and postpartum women’s preferences for novel long-acting (LA)-PrEP formulations and identify early process indicators for implementing these options in maternal and child health (MCH) systems. These data will inform tailored HIV prevention strategies for pregnant/postpartum women at risk of HIV and provide opportunities for the F31 candidate to gain expertise in new methods and advance as an independent investigator.

PI_NAMEs: CONCEPCION, TESSA LEIGH (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Acceleration;Address;Adherence;Age;AIDS prevention;Automobile Driving;Characteristics;Clinical;Code;Country;County;Data;Dose;Early identification;Effectiveness;effectiveness-implementation RCT;effectiveness/implementation hybrid;Evaluation;experience;experimental analysis;experimental study;Exploration, Preparation, Implementation, and Sustainment;Face;Family Sizes;Female Adolescents;Focus Groups;forgiveness;formative assessment;Formulation;Frequencies;future implementation;Goals;Health;health care availability;Health system;high risk;High Risk Woman;HIV;HIV risk;implementation determinants;implementation evaluation;implementation framework;implementation outcomes;implementation process;implementation research;implementation science;implementation study;improved;Incidence;Income;informant;Injectable;Interview;Kenya;Maps;Maternal and Child Health;Measurement;Methods;Modality;Modeling;motherhood;Nausea;novel;Oral;Parents;Participant;Perinatal;perinatal period;pill;Population;Positioning Attribute;post pregnancy;Postpartum Period;Postpartum Women;pre-doctoral;pre-exposure prophylaxis;preference;Pregnancy;Pregnant Women;Prevention;Prevention Research;Prevention strategy;Process;Prospective cohort;Provider;Qualitative Research;Research;Research Personnel;scale up;side effect;social;social determinants;Southern Africa;structural determinants;Symptoms;Techniques;Training;Transcript;transmission process;uptake;Vaginal Ring;Vertical Transmission;Visit;Woman;Work;young woman

PROJECT_TITLE: Planning for delivery of novel PrEP formulations to pregnant and postpartum women in Kenya


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Effective drugs to treat kidney fibrosis, which is the primary cause of end-stage renal failure in chronic kidney disease, are lacking. Transforming growth factor beta2 (TGF-β2) is a protein that triggers fibrosis in the kidney and is thus an important drug target. In the body, TGF-β2 exists mainly in an inactive form, and the goals of this proposal are to determine the mechanisms that keep TGF-β2 inactive and to develop innovative drugs that stop TGF-β2 from becoming active as a way to prevent kidney fibrosis.

PI_NAMEs: LE, VIET QUOC (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Affinity;Antibodies;antibody libraries;Aristolochic Acids;Binding;Binding Proteins;Biological Assay;Biology;Blocking Antibodies;Blood Platelets;Boston;Capital;Cardiovascular Diseases;career;career development;Cell Cycle Arrest;Cell Line;cell type;Cells;Chronic Kidney Failure;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complement;Complex;Crystallization;Crystallography;Data;Deposition;Deuterium;Development;Diabetic Nephropathy;diabetic rat;dimer;disease model;DNA Damage;DNA Insertion Elements;drug development;drug discovery;Drug Kinetics;Drug Targeting;Education;Electron Microscopy;End stage renal failure;Endothelial Cells;Ensure;Environment;Epithelial Cells;Epitopes;Etiology;Exhibits;Expression Profiling;extracellular;Extracellular Matrix;Failure;Fellowship;Fibroblasts;Fibrosis;Follow-Up Studies;Foundations;Functional disorder;Future;Genetic;global health;Goals;Grant;Growth;Growth Factor;Hospitals;Human;Hydrogen;Immunofluorescence Microscopy;Immunoglobulin G;improved;in vitro activity;in vivo;Infiltration;Inflammatory;Infrastructure;Injury to Kidney;innovation;insertion/deletion mutation;insight;Institution;Integrin Inhibition;Integrins;Ischemia;Kidney;Kidney Diseases;kidney fibrosis;Knock-in Mouse;lead candidate;Libraries;Link;LRRC32 gene;M cell;Mediating;medical schools;Mentors;Mentorship;Modality;model building;Modeling;Molecular;Molecular Biology;Molecular Conformation;Monitor;mortality;mouse model;Mus;Mutation;Myofibroblast;nanobodies;National Institute of Diabetes and Digestive and Kidney Diseases;Negative Staining;novel strategies;novel therapeutic intervention;novel therapeutics;Pathway interactions;Pediatric Hospitals;Pericytes;Pharmaceutical Preparations;prevent;programs;Property;Protein Biochemistry;Proteins;Regulatory T-Lymphocyte;Renal function;repaired;Reperfusion Therapy;Reporter;Research;Research Personnel;Resolution;Resources;response;Role;Signal Transduction;skills;structural biology;Structure;success;Surface;symposium;System;Techniques;Testing;Therapeutic;Therapeutic antibodies;therapeutic development;therapeutic evaluation;therapeutic target;Training;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;Transforming Growth Factor beta Receptors;Treatment Efficacy;Ureteral obstruction;Vocational Guidance;Woman;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Blocking Latent TGF-β2 Activation as a Therapeutic Strategy for Renal Fibrosis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Digestive Diseases - (Gallbladder);Genetics;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The objective of this proposal is to delineate molecular mechanism underlying hepatocyte-driven intrahepatic cholangiocarcinoma (ICC) development, thereby to contribute for better understanding of the disease pathogenesis as well as identifying novel therapies for this devastating tumor via precision medical approaches. Thus, our proposal addresses a major unmet clinical need. 1

PI_NAMEs: KO, SUNGJIN  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Address;Automobile Driving;Azacitidine;Biliary;Binding;Bioinformatics;bioinformatics tool;Biological Markers;bisulfite sequencing;Cell Differentiation process;Cells;ChIP-seq;Cholangiocarcinoma;chronic liver disease;Clinic;Clinical;clinically relevant;cohort;Data;Data Set;Development;Disease;Disparate;Doxycycline;Epigenetic Process;Epithelial Cells;Excision;Exposure to;Gene Expression;Genes;Genetic;genetic signature;Genetic Transcription;Genome;Hepatocyte;Heterogeneity;Human;in vivo;inhibitor;Injury;innovation;Intrahepatic Cholangiocarcinoma;Liver;Liver Stem Cell;Malignant neoplasm of liver;Mediating;Medical;methylome;Modeling;Molecular;Molecular Profiling;Mus;mutant;neoplastic cell;new therapeutic target;Newly Diagnosed;notch protein;novel therapeutics;Oncogenes;Operative Surgical Procedures;Pathogenesis;Pathologic;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation Site;Plasmids;Play;pre-clinical;precision medicine;prevent;Proto-Oncogene Proteins c-akt;Repression;response;Risk;Role;Signal Transduction;Site;Sleeping Beauty;small molecule;Survival Rate;System;Tamoxifen;targeted treatment;Testing;theories;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapeutic target;Thioacetamide;Time;tool;toxicant;Toxin;transcriptome sequencing;tumor;tumor growth;tumor heterogeneity;tumor initiation;tumorigenesis;Unresectable;Zebrafish

PROJECT_TITLE: Identifying therapeutic options for intrahepatic cholangiocarcinoma

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Appreciating how chromosomes X and Y regulate sex differences in the brain is critical to understanding how autism spectrum disorder (ASD) develops and why more boys are diagnosed than girls. This proposal will examine how chromosome Y in particular regulates crucial functions of microglia in brain maturation. The ultimate goal of this proposal is to gain insight into microglial dysregulation in atypical neurodevelopment and to identify mechanisms for sex-specific interventions for ASD.

PI_NAMEs: NGUYEN, CELINA TIEN (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Affect;Age;Aneuploidy;Architecture;Area;ATAC-seq;autism spectrum disorder;Behavior assessment;behavior test;Behavioral;Biological;Biological Models;Biology;boys;Brain;brain abnormalities;brain cell;career;cell type;Cells;Child;ChIP-seq;Chromosomes;Clinical;cytokine;Data;Defect;density;Development;Diagnosis;Disease;Dose;Engraftment;Environment;epidemiologic data;Epigenetic Process;experience;Female;Functional disorder;Future;Gene Expression;Gene Expression Regulation;gene network;Genes;Genetic study;Genetic Transcription;Genome;genome-wide;Genomics;genotypic sex;girls;Glass;glial activation;Goals;Gonadal Steroid Hormones;hands-on learning;Heritability;Human;human induced pluripotent stem cells;human model;Hypertrophy;Immune;Immunohistochemistry;Immunologics;improved outcome;In Vitro;in vivo;Incidence;individuals with autism spectrum disorder;Inflammatory Response;innovation;insight;Intervention;Knowledge;Laboratories;large datasets;Lifestyle-related condition;Link;Macrophage;male;Measures;Mentorship;Microglia;migration;Modeling;Molecular;Morphology;Mus;nerve stem cell;neurodevelopment;Neurodevelopmental Disorder;neuroimmunology;neuronal circuitry;neuropathology;novel;Outcome;Pathogenesis;Pathologic;Pathology;Phenotype;Physicians;Population Density;Prevalence;Production;Puberty;Regulation;reproductive tract;Research;Resources;Rest;Risk Factors;Role;Scientist;Severities;sex;Sex Bias;Sex Chromosomes;Sex Differences;sexual dimorphism;skills;stem cell model;Structure;Synaptosomes;Testing;Thick;Tissues;transcriptome sequencing;transcriptomics;United States;Vertebral column;X Chromosome;Xenograft Model;Xenograft procedure;Y Chromosome

PROJECT_TITLE: The Role of Chromosome Y in Human Microglia and Neurodevelopment


ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Public Health Relevance. Stents are the most common cardiovascular implants used in the treatment of cardiovascular diseases. However, there are limitations with current stents and preclinical animal models. Development of innovative strategies for a dual action prohealing nanomatrix stent coating and an engineered atherosclerosis model will contribute to the advance of stent industry.

PI_NAMEs: JUN, HO-WOOK  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Address;Adolescent;Adverse effects;analog;Animal Model;antiproliferative agents;Apoptosis;Arteries;Atherosclerosis;Biochemical Pathway;Biological;Bioreactors;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;cell motility;Cell Physiology;Cell Proliferation;Cells;Chemicals;Clinical;clinical effect;Development;Dose;efficacy evaluation;Encapsulated;Endothelial Cells;endothelial dysfunction;Endothelium;Engineering;Environment;Evaluation;Exhibits;Fibroblasts;Foam Cells;Formulation;Goals;healing;High Fat Diet;high risk;human model;Hyperplasia;iliac artery;Immunosuppressive Agents;Impairment;Implant;implantable device;implantation;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Industry;Inflammation;Inflammatory Response;injured;Injury;innovation;Legal patent;Liposomes;Metals;migration;Modeling;nano;Nitric Oxide;novel;novel strategies;Oryctolagus cuniculus;Outcome;Patients;peptide amphiphiles;Performance;Pharmaceutical Preparations;Physiological;Polymers;porcine model;pre-clinical;Proliferating;Property;Protocols documentation;public health relevance;response;restenosis;Safety;Sirolimus;Smooth Muscle;Smooth Muscle Myocytes;stent thrombosis;Stents;Structure;Study models;targeted agent;vascular injury

PROJECT_TITLE: Dual action nanomatrix coated stent evaluation using engineered artery sheets with atherosclerotic features

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: GALVESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Project Narrative Alzheimer’s disease (AD) and related dementias are characterized by the aggregation of tau protein. The heterogonous nature of the tau aggregates is a challenge for developing detection methods and treatments. The characterization of disease relevant tau polymorphs/strains will advance early diagnostics and development of therapeutic strategies which would improve the health and well-being of millions of people in the US.

PI_NAMEs: KAYED, RAKEZ  (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Area;Biochemical;Biologic Characteristic;Biological;Biology;Biophysics;Brain;Brain region;Cell model;Cellular Assay;Characteristics;Clinical Trials Design;comorbidity;Data;Deposition;design;detection method;Diagnosis;Diagnostic;Disease;disease phenotype;Disease Progression;Evaluation;Functional disorder;Future;Genetic;Genotype;Grant;Health;Immunologics;improved;In Vitro;in vivo;insight;Mission;Molecular;Molecular Conformation;Nature;Neurodegenerative Disorders;Neurofibrillary Tangles;novel;Outcome Study;Pathologic;Pathology;Personal Satisfaction;personalized medicine;personalized therapeutic;Persons;Polymorph;Prion Diseases;Property;protein aggregation;Proteins;Reaction;Recombinants;Reproducibility;Resolution;Role;Sampling;Series;Stains;Structure;Symptoms;tau aggregation;tau Proteins;Tauopathies;Therapeutic;therapeutic development;Toxic effect;United States National Institutes of Health;Variant

PROJECT_TITLE: Formation and Propagation of Tau Oligomeric Strains in Alzheimer's Disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND-R]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Narrative: The Personalized Cross-sector Transitional Care Management (PC-TCM) project seeks to promote care continuity, reduce low value utilization, and reduce the burden of treatment for high-need, high-cost patients receiving care across health, specialty and social care sectors. The project will expand the evidence- based R21 Care Transitions Intervention (CTI) to bring social sector providers as equal partners in HNHC care, refine CTI HIE capacity to include cross-sector care alerts and a personalized care plan, and evaluate the impact of PC-TCM from a patient and provider perspective.

PI_NAMEs: HEWNER, SHARON  (contact)

PROGRAM_OFFICER_NAME: CHANEY, KEVIN

PROJECT_TITLE: Implementing personalized cross-sector transitional care management to promote care continuity, reduce low value utilization, and reduce the burden of treatment for high-need, high-cost patients

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: PHYSIOLOGY

PHR: Chromatin remodelers are the enzymes responsible for establishing and maintaining this genome packaging, acting to physically expose or bury particular DNA sequences within genes. Disruptions of chromatin remodelers have been directly linked to cancer and other human diseases, highlighting the important role of chromatin remodeling for proper cellular growth and survival. By uncovering the mechanisms by which chromatin remodelers reshape the physical packaging of the genome, we hope to better understand fundamental processes that are essential for human health.

PI_NAMEs: BOWMAN, GREGORY DEAN (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: absorption;Address;Affect;ATP Hydrolysis;ATP phosphohydrolase;ATPase Domain;Binding;Binding Sites;Biological Models;cancer type;cell growth;Cell Physiology;CHD1 gene;Chromatin;chromatin remodeling;Collaborations;Coupled;Coupling;crosslink;Cryoelectron Microscopy;Defect;developmental disease;dimer;Disease;DNA;DNA Binding Domain;DNA biosynthesis;DNA Crosslinking;DNA Repair;DNA Sequence;Elements;Enzymes;Experimental Designs;experimental study;Genes;Genetic Transcription;Genome;Growth and Development function;Health;helicase;Histones;Human;human disease;Hydrolysis;insight;ISWI;Kinetics;Link;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Modeling;Molecular Conformation;Motor;Mutagenesis;Mutation;Normal Cell;Nucleosomes;Nucleotides;Physical shape;Positioning Attribute;preference;Process;Reagent;Regulation;Reporting;Role;Side;single-molecule FRET;Site;Slide;Stem cell pluripotency;Structural Models;Structure;Testing;translocase;unpublished works;Variant

PROJECT_TITLE: Structural and Functional Characterization of the Chd1 Chromatin Remodeler


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Nutrition;Pediatric;Polycystic Kidney Disease

PHR: The proposed studies will examine molecular mechanisms regulating potassium secretion in the distal nephron. The studies will define the role of a mechanically regulated ion channel, Piezo1, in increasing intracellular calcium and facilitating potassium secretion into the urine when urinary flow rates increase and in response to a high potassium diet. This work has the potential to uncover mechanisms involved in the development and/or maintenance of potassium disorders, and identify potential targets for novel therapies to treat imbalances in potassium.

PI_NAMEs: KLEYMAN, THOMAS R (contact);SATLIN, LISA M.

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Actins;Adult;Affect;Aldosterone;Apical;Attention;basolateral membrane;Bicarbonates;Binding;Brush Border;Calcium;Cations;Cell Differentiation process;Cell membrane;Cell Physiology;cell type;Cells;Cilia;Coupled;Cytoskeleton;Development;Diameter;Diet;Dietary Potassium;Disease;Distal;Duct (organ) structure;Epithelial Cells;epithelial Na+ channel;Equation;Event;Excretory function;Exhibits;experimental study;extracellular;Extracellular Matrix;Family;Genetic;inhibitor;Intake;Intercalated Cell;Ion Channel;Kidney;large-conductance calcium-activated potassium channels;Life;Link;Liquid substance;Location;Maintenance;mechanical force;Mechanics;mechanotransduction;Mediating;member;Membrane;Molecular;Mus;Natural Immunity;neonatal mice;Nephrons;new therapeutic target;novel;patch clamp;Pathway interactions;Perfusion;Phase;Piezo 1 ion channel;Piezo ion channels;PKD2 protein;polycystic kidney disease 1 protein;postnatal;Potassium;Radial;Reporting;response;Role;sensor;shear stress;Stretching;Testing;transmission process;Tubular formation;urinary;Urine;Variant;Work

PROJECT_TITLE: Role of piezo channels in intercalated cells

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD), the most common form of dementia, creates a devastating burden on patients, caregivers, healthcare systems, and the broader society. Because available treatments primarily offer symptom management rather than significant disease modification or reversal, it is imperative to identify potential avenues for delaying the onset of the disease or curbing its progression. Accordingly, the overarching objective of this integrative, clinically-relevant study is to rigorously investigate the extent to which the longevity gene KLOTHO offers resilience against age- and AD-related synaptic dysfunction and modifies the relationship between such dysfunction and cognitive decline with a potential to reduce AD risk and its socio-economic footprint.

PI_NAMEs: FRAHMAND, IRA  (contact);OKONKWO, OZIOMA C

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Abate;abeta accumulation;Address;Adult;Adverse effects;Age;age effect;age related changes;Age-associated memory impairment;Aging;aging gene;aging population;alpha synuclein;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid beta-42;Amyloid beta-Protein;anti aging;apolipoprotein E-4;Attenuated;attenuation;Belief;beta amyloid pathology;Biological Markers;Blood;blood-based biomarker;Brain;Caregivers;Central Nervous System;Cerebrospinal Fluid;Clinical;clinically relevant;Cognitive;Cognitive deficits;cognitive performance;cohort;curative treatments;Dementia;density;Dependence;Deterioration;disability;Disease;druggable target;Elderly;executive function;Exhibits;follow-up;Functional disorder;Genes;Genetic Risk;Genotype;Health;Healthcare Systems;Heterozygote;heuristics;Human;human old age (65+);Imaging ligands;Impaired cognition;in vivo;Incidence;indexing;Individual;individual variation;insight;Integral Membrane Protein;Investigation;Kinetics;Light;Longevity;longevity gene;Mediating;Memory;Memory Loss;Metabolism;Methodology;middle age;Modification;mouse model;multimodality;N-Methylaspartate;Nerve Degeneration;Nervous System Disorder;Neurofibrillary Tangles;neurofilament;neurogranin;Neurons;neuropathology;neurotoxic;Onset of illness;Participant;Pathologic;Patients;Phenotype;Play;Positioning Attribute;Positron-Emission Tomography;pre-clinical;prevent;Process;Public Health;Registries;Research;Research Priority;resilience;Resistance;Resources;Risk;Risk Factors;Senile Plaques;sex;Societies;socioeconomics;stem;symptom management;Synapses;synaptic function;Synaptic plasticity;Syndrome;tau Proteins;tau-1;translational study;Tsunami;uptake;Variant;Wisconsin;Work;β-amyloid burden

PROJECT_TITLE: KLOTHO and Resilience to Synaptic Dysfunction in Preclinical AD

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]