NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Diabetes;Immunotherapy;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative: Dysregulation in immune tolerance mechanisms leading to unbridled reactivity to self-antigens precipitates tissue damage, functional loss, and multi-organ afflictions and culminate in autoimmune diseases, whose societal impact, exemplified by conditions such as type 1 diabetes, underscores the need for innovative approaches capable of safely and selectively modulating immune cells responsible for driving pathogenic processes. This research endeavors to advance our comprehension of lymph nodes as focal points for immune tolerance induction and aims to assess novel therapeutic strategies for autoimmune diseases, leveraging engineered stromal cells as agents for promoting tolerance. By elucidating the intricacies of lymph node-mediated immune tolerance and evaluating innovative therapies, this project seeks to contribute substantively to the development of effective interventions for preventing and treating autoimmune diseases.

PI_NAMEs: CREUSOT, REMI J (contact);TOMEI, ALICE

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: adaptive immunity;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Autoantigens;Autoimmune Diabetes;Autoimmune Diseases;Autoimmunity;Automobile Driving;autoreactive T cell;Beta Cell;Biocompatible Materials;bioscaffold;Blocking Antibodies;Cell model;Cells;cellular engineering;central tolerance;Coculture Techniques;Comprehension;Cytoskeleton;cytotoxicity;Data;Development;diabetic;Diabetic mouse;diabetogenic;effective intervention;engineered T cells;Engineering;Frequencies;functional loss;Genetic Engineering;HLA-A2 Antigen;Human;Immune response;Immune Tolerance;immunoengineering;Immunology;immunoregulation;Impairment;In Vitro;in vivo;Inbred NOD Mice;Incidence;inducible Cre;inducible gene expression;Inflammation;innovation;Innovative Therapy;Insulin;Insulin-Dependent Diabetes Mellitus;interest;islet;Lead;LoxP-flanked allele;lymph nodes;Lymphoid;Maintenance;Mediating;mesenchymal stromal cell;Modeling;Modification;mouse model;Mus;Nature;Non obese;novel;novel therapeutic intervention;Organ;Organ Donor;Pancreas;Pathogenicity;Pathway interactions;Peptide Signal Sequences;Peripheral;peripheral tolerance;Phenotype;Positioning Attribute;preproinsulin;prevent;Process;Professional Role;programmed cell death ligand 1;Proliferating;Property;Regulation;Regulatory T-Lymphocyte;Relaxation;Reporting;Research;Reticular Cell;Reticulum;reticulum cell;Role;scaffold;Spleen;stem cells;Stromal Cells;System;T cell anergy;T cell response;T-Lymphocyte;Testing;Therapeutic;Thymus Gland;Tissues;Transforming Growth Factor beta;Transgenic Mice;type I diabetic;Work

PROJECT_TITLE: Unraveling the tolerogenic potential of lymph node fibroblastic reticular networks in autoimmune diabetes

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Immune checkpoint inhibitors (ICI) are a revolutionary highly effective anti-cancer treatment and are associated with immune mediated acute kidney injury (AKI) through unclear mechanisms. ICI mediated immune system activation may lead to excessive immune responses to medications such as beta-lactam antibiotics, which themselves cause AKI via acute interstitial nephritis. This study aims to estimate the comparative risk and treatment effect heterogeneity of AKI in patients on ICIs concomitantly exposed to beta-lactam versus fluroquinolone antibiotics, which are widely used alternatives to beta-lactams.

PI_NAMEs: THELEN, HAEDI  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;anti-cancer treatment;Antibiotics;Antigens;beta-Lactams;cancer complication;Cancer Patient;Cancer Remission;cancer therapy;cancer type;care costs;career;career preparation;Cefepime;checkpoint therapy;chemotherapy;Clinical;clinical practice;Combined Modality Therapy;comparative;Data;Data Set;Diabetes Mellitus;Disease remission;Doctor of Philosophy;Drug Interactions;Early Diagnosis;Electronic Health Record;Eligibility Determination;empowerment;Epidemiologic Methods;Epidemiology;Equilibrium;Etiology;Exposure to;Fellowship;Fluoroquinolones;Frequencies;Future;Health system;Heart failure;Heterogeneity;human old age (65+);Hyperactivity;Immune;Immune checkpoint inhibitor;Immune response;Immune system;immune-related adverse events;Immunologic Factors;Incidence;Individual;Infection;Inflammatory Response;insight;Interstitial Nephritis;Intravenous;Kidney;Levaquin;Literature;Maintenance;Malignant Neoplasms;Mediating;Mentors;Mentorship;Methods;modifiable risk;Monitor;mortality;Nature;neoplastic cell;Nephrology;nephrotoxicity;novel;novel therapeutics;Oncology;optimal treatments;Patients;Pennsylvania;Pharmaceutical Preparations;Pharmacists;Pharmacoepidemiology;Population;prevent;Probability;prognostic;programs;protein complex;Regimen;Reporting;Research;Research Personnel;response;Retrospective cohort study;Risk;Risk Factors;Role;skills;Stratification;Subgroup;success;Supportive care;T-Cell Activation;T-Lymphocyte;Therapeutic;Training;treatment effect;trial comparing;Universities;Weight

PROJECT_TITLE: Acute Kidney Injury with Immune Checkpoint Inhibitors and Beta-Lactam Antibiotics

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Kidney, Urology, and Hematology[DDK-G]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Pain Research;Prevention;Substance Misuse

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Narrative Clarifying the underlying processes contributing to chronic pain and substance use comorbidity has the potential to inform substance use prevention and treatment initiatives for individuals with chronic pain. Evidence of associations between chronic pain and substance use consistent with a causal hypothesis would suggest that addressing chronic pain is critical for reducing risk of substance use. Alternatively, evidence inconsistent with a causal role of pain would suggest that intervening on other underlying factors may be more effective.

PI_NAMEs: SUMMIT, ALYNNA  (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Accounting;Address;Adult;adverse outcome;Affect;career;chronic pain;chronic painful condition;Clinical;cohort;comorbidity;design;Development;Diagnosis;Distress;Drug Use Disorder;Elements;Environment;Etiology;Fibromyalgia;Fostering;Genes;Genetic;Goals;Heterogeneity;Hospitalization;Individual;innovation;Inpatients;Knowledge;Link;Low Back Pain;Methodology;Modeling;mortality;Nature;Neurobiology;Opioid Analgesics;Outcome;Outpatients;Overdose;Pain;Pain management;Patient Self-Report;population based;prescription opioid misuse;Process;prospective;Records;Research;Risk;Risk Reduction;Role;Science;Services;Siblings;skills;Source;Specialist;substance use;Substance Use Disorder;substance use prevention;Testing;Training;Twin Multiple Birth;Twin Studies;United States

PROJECT_TITLE: Evaluating the Association Between General Chronic Pain Liability and Clinically Recognized Substance Use

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will advance our understanding by which postpartum depression symptoms can be prevented and treated among Black birthing people. Interventions that protect against social stress, including racism-related stress, in perinatal care have potential to reduce racial and ethnic disparities in postpartum depression symptomology. This research proposal’s overall objective to test a perinatal care intervention on postpartum depression symptomology among Black birthing people aligns with the NIMHDs’ 2021-2025 strategic goal 3: “Develop and test interventions to reduce health disparities”.

PI_NAMEs: DE ORNELAS, MARIA  (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Address;analytical method;Birth;Black race;Buffers;California;Caring;Communities;comparison group;County;Data;data anonymization;data de-identification;Decision Making;depressive symptoms;Disparity;Education;electronic health data;Electronic Health Record;ethnic disparity;Evaluation;Evidence based practice;experience;Goals;Health;health care model;health care service;health care settings;Health Disparities Research;health disparity populations;health equity;Health Services;Health system;improved;Infant;insight;Intervention;Medicaid eligibility;Mental Health;Mentorship;Midwifery;Modeling;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;Outcome;Participant;patient oriented;Patient-Centered Care;Patients;Perinatal;Perinatal Care;perinatal health;peripartum depression;Persons;Physiological;Postpartum Depression;Postpartum Period;pragmatic trial;Pregnancy;prevent;Prevention;preventive intervention;programs;Public Health;Quasi-experiment;Race;racial disparity;racism;Reduce health disparities;Reporting;Research;Research Design;Research Personnel;Research Proposals;Resource-limited setting;Resources;social;social stress;Social support;Stress;Surveys;Testing;treatment group;Visit;Work

PROJECT_TITLE: Advancing Perinatal Health Equity through a Community-engaged Model of Healthcare Services

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: TALLAHASSEE

ORG_DEPT: BIOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Temperature is an intra-oral cue relevant to food preference and nutrition; while it is intimately related to the chemosensory features of food and beverages, we have surprisingly very little knowledge on its role in taste perception. This research project will use a combination of rigorous hypothesis-based behavioral testing and neural recording to carefully evaluate how temperature alters the taste quality discriminability of sodium and non-sodium salts and their neural representations. The experiments in this proposal will provide a comprehensive behavioral and neurophysiological investigation on how temperature operates on sensory processes associated with taste, and will pave the way for future investigations on the neural circuits and operational principles underlying thermogustation in behaving mice.

PI_NAMEs: MARQUES, MARIELA  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Affect;Altered Taste;Behavior assessment;behavior test;Behavioral;behavioral study;Beverages;Brain region;Cardiovascular system;Cessation of life;Chemicals;Chemoreceptors;Code;Consumption;Crossover Design;Cues;Data;design;Detection;Diet;dietary salt;Discrimination;Electrophysiology (science);Elements;Esthesia;experience;experimental study;Female;Food;food consumption;Food Preferences;Future;Goals;Health;Hypertension;in vivo;Induced Neurons;Investigation;Knowledge;Laboratories;male;Mus;neural;neural circuit;Neurons;neurophysiology;nutrition;Oral cavity;Pattern;Perception;Performance;Physiological;preference;Property;Psychometrics;Psychophysics;Publications;Research;Research Personnel;Research Project Grants;response;Risk;Role;Salts;Sampling;Sensory;Sensory Process;Shapes;Signal Transduction;Sodium;Sodium Chloride;somatosensory;Stimulus;Stroke;Subgroup;Taste Perception;taste stimuli;taste system;Techniques;Temperature;Testing;Time;Training;Work

PROJECT_TITLE: Investigating How Temperature Shapes Salt Perception.

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Y (52)]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;HIV/AIDS;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: PROJECT NARRATIVE The nearly 14 million African children who are HIV exposed but uninfected are at risk for poor health outcomes, including neurodevelopmental conditions such as autism; yet, there is a lack of expertise and diagnostic tools to carry out autism research in low- and middle-income countries. By leveraging a longitudinally assessed cohort of children, the proposed study will examine autism diagnostic outcome and eye-tracking markers in children who are HIV exposed and unexposed while building capacity for neuro-health research in Kenya. This study will be the first to rigorously examine autism outcomes in HIV exposed children and determine the validity of eye- tracking markers as a potential scalable diagnostic tool in resource-constrained settings, culminating in a Global Neuro-Health Collaborative well prepared to carry forward high impact transformative autism research in Kenya.

PI_NAMEs: KEEHN, BRANDON ;MCNALLY KEEHN, REBECCA  (contact);OYUNGU, EREN

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Achievement;adverse birth outcomes;Africa;African;Age;antiretroviral therapy;Autism Diagnosis;Autism diagnostic;autism spectrum disorder;Breast Feeding;Child;Child Health;Clinical;cohort;Communities;cost;Country;Data;Detection;Diagnostic;diagnostic tool;diagnostic value;global health;Health;Health Services Accessibility;High Prevalence;HIV;HIV therapy;improved;Income;inflammatory marker;innovation;Intellectual functioning disability;Intervention;Investigation;iron deficiency;Iron deficiency anemia;Kenya;Longitudinal cohort;low and middle-income countries;Measures;Mediating;Mentorship;Methodology;Methods;Modeling;Morbidity - disease rate;Mothers;National Institute of Child Health and Human Development;neural;neurobehavioral;Neurocognitive;Neurosciences Research;Outcome;Pathway interactions;Perinatal;Persons;poor health outcome;Positioning Attribute;predictive marker;premature;Procedures;Process;programs;Research;Research Activity;Research Priority;Resource-limited setting;Resources;Risk;Risk Factors;Science;Series;Strategic Planning;success;Testing;tool;Training;transmission process;United States National Institutes of Health;visual tracking;Work

PROJECT_TITLE: The Alama Project: Autism outcomes and neurobehavioral markers in young children born to mothers with HIV in Kenya

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-L (55)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Alpha-synuclein (aSyn) accumulation and misfolding is implicated in the pathogenesis of Parkinson's Disease and related synucleinopathies and leads to numerous cellular dysfunctions like disrupted proteostasis. As preclinical disease models become more complex to better recapitulate disease relevant pathophysiology — i.e., monoculture ➔ 2D co-culture ➔ 3D organoids (both mono- and co-cultured) ➔ in vivo — advanced multiplexing technologies that are capable of dynamic temporal and spatial monitoring of protein-protein interactions (e.g., aSyn oligomerization and misfolding) and pathological phenotypes (e.g., disrupted autophagy lysosomal pathway) are required. Our proposed Dark-FRET (DF) and Dual-Channel DF (DCDF) biosensors offer improved live-cell monitoring, allowing simultaneous tracking of aSyn folding and aggregation dynamics in distinct cell populations and facilitating the exploration of complex disease models, providing insights into diverse cellular pathways involved in synucleinopathies.

PI_NAMEs: SACHS, JONATHAN N (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 3-Dimensional;Address;alpha synuclein;Alzheimer's disease related dementia;Amyloid Proteins;Animals;assay development;Astrocytes;Autophagocytosis;Biological;Biological Assay;Biosensor;Caenorhabditis elegans;Cell Line;Cell model;cell type;Cells;Central Nervous System;Coculture Techniques;Communities;comorbidity;Complex;Darkness;Dementia with Lewy Bodies;Development;Dimerization;Disease;disease model;driving force;drug discovery;endoplasmic reticulum stress;Engineering;Environment;Fluorescence;Fluorescence Resonance Energy Transfer;Functional disorder;functional outcomes;Generations;Health;high throughput screening;human induced pluripotent stem cells;Image Analysis;improved;in vivo;in vivo Model;Induced pluripotent stem cell derived neurons;innovation;insight;Kinetics;Libraries;Lysosomes;Microglia;mitochondrial dysfunction;Modeling;Monitor;multicatalytic endopeptidase complex;Muscle;Nature;Neurodegenerative Disorders;Neuroglia;neuron development;Neurons;new technology;novel;novel therapeutic intervention;Nuclear Translocation;Organoids;Parkinson Disease;Pathogenesis;Pathologic;Pathway interactions;Phenotype;Physiological;Population;pre-clinical;Pre-Clinical Model;Process;Protein Engineering;protein misfolding;protein protein interaction;Proteins;proteostasis;proteostasis loss;quantum;real time monitoring;Research;Research Personnel;Resolution;response;Role;Running;Sampling;segregation;Series;Signal Transduction;small molecule;synucleinopathy;System;Technology;technology platform;Testing;Therapeutic;Tissues;tool;Translating;Ubiquitin

PROJECT_TITLE: Advanced multiplexing technologies with innovative Dual-Channel Dark-FRET biosensors for dynamic monitoring of alpha-synuclein pathophysiology: From cellular to in vivo models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (80)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Vascular degenerative disease has emerged as one the most important modern public health crises facing our aging population, in which the epidemic rise of diabetes and renal disease has resulted in an unprecedented burden of cardiovascular morbidity and mortality. In chronic limb-threatening ischemia (CLTI) — the most severe form of peripheral artery disease — diabetic and renal metabolic syndromes have shifted the pattern of disease toward the smaller vessels of the leg and foot, in which progressive calcification replaces the normal contractile arterial media, obliterates vascular outflow and renders standard therapies ineffective, ultimately resulting in high rates of treatment failure and limb amputation. The proposed research plan will provide crucial insight into the pro-calcific molecular and cellular alterations that occur under conditions of hemodynamic and metabolic stress in CLTI, focusing on the role of the anti-aging gene Klotho as a key regulator of arterial calcification — ultimately with the goal of identifying therapeutic targets to prevent or reverse vascular calcification and improve both human longevity and quality of life.

PI_NAMEs: LIU, IRIS  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Aging;aging gene;aging population;American;Amputation;anti aging;Area;Arterial Medias;Arteries;Basic Science;Benchmarking;Biochemical;Biomechanics;Biomedical Engineering;Biomimetics;Blood Vessels;calcification;Calcium;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular system;career;Cells;Characteristics;Chronic;Chronic Kidney Failure;Clinical;Clinical Research;Data;Degenerative Disorder;Deposition;Diabetes Mellitus;diabetic;Diabetic Nephropathy;Disease;Distal;effective therapy;Engineering;Environment;Epidemic;Failure;Fellowship;foot;Gene Expression;Goals;hemodynamics;Homeostasis;Human;Human Engineering;human tissue;Hyperglycemia;improved;ineffective therapies;innovation;inorganic phosphate;insight;Institution;insulin signaling;Investigation;Ischemia;Kidney;Kidney Diseases;Knowledge;Leg;limb amputation;Limb structure;Longevity;Longitudinal, observational study;Lower Extremity;Measures;Medial;Mediating;Membrane;Mentors;Metabolic;Metabolic Diseases;Metabolic stress;Metabolic syndrome;Microfluidics;Modeling;Modernization;Molecular;Morbidity - disease rate;mortality;multidisciplinary;new therapeutic target;novel;Osteogenesis;osteogenic;Outcome;Pathogenesis;Pathologic;Pathway interactions;patient population;Patients;Pattern;Peripheral arterial disease;Persons;Phenotype;Play;Population;prevent;Public Health;Quality of life;radiological imaging;Regulation;Research;Research Personnel;Resources;response;revascularization;Reverse engineering;Risk Factors;Role;Sampling;Scientist;Serum;shear stress;Smooth Muscle Myocytes;Specimen;Stress;stressor;Surgeon;System;targeted treatment;Technical Expertise;therapeutic target;tissue culture;Tissue Model;Tissue Sample;Tissues;transcriptome;transdifferentiation;translational framework;Treatment Failure;Vascular calcification;Vascular Diseases;Vascular Smooth Muscle;Work

PROJECT_TITLE: Cardiometabolic disease and vascular aging: Klotho regulation of medial arterial calcification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-B (20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_STATE: NY

PHR: Project Narrative Gestational diabetes (GDM) is a common complication of pregnancy with profound implications for life course disparities in type 2 diabetes (T2DM) and cardiovascular disease. Very little is known about what causes racial-ethnic disparities of T2DM to emerge in the years after a GDM pregnancy, and the structural influences that have a disproportionately negative impact Black, Latina, and South Asian women. To fill this gap, we propose a concurrent mixed-methods study, leveraging a population-based retrospective cohort of HbA1c levels 10 years after GDM, qualitative interviews with postpartum women, and an innovative systems science modeling approach, to identify policy levers to prevent progression to T2DM after GDM in the postpartum period and reduce racial-ethnic disparities.

PI_NAMEs: JANEVIC, TERESA  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: Affect;Asian Women;barrier to care;Birth Certificates;Black race;built environment;cardiometabolic risk;Cardiovascular Diseases;Clinical;cohort;cost effective;Data;Data Linkages;data registry;Databases;deprivation;design;Diabetes Mellitus;Diabetes prevention;diabetes risk;Diagnosis;Diet;Disadvantaged;Disease;Disparity;Economics;Environment;Equity;ethnic difference;ethnic disparity;ethnic diversity;Ethnic Origin;experience;Face;food environment;Gestational Diabetes;Glycosylated hemoglobin A;Goals;good diet;Green space;health care availability;Health system;high risk;Immigrant;improved;Individual;Inequity;innovation;Intervention;Interview;Latina;Life Cycle Stages;Literature;Lived experience;Maps;Measures;Mental Health;Methods;Modeling;multi-ethnic;National Institute of Diabetes and Digestive and Kidney Diseases;Neighborhoods;New York City;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Patients;Physical activity;Physiological;Policies;Policy Maker;population based;Postpartum Period;Postpartum Women;Prediabetes syndrome;Pregnancy;Pregnancy Complications;prevent;Prevention;protective factors;Race;racial difference;racial disparity;Registries;Research;Research Design;Research Priority;Resources;Retrospective cohort;Risk;Risk Factors;Safety;Science;Signal Transduction;social;social cohesion;Social Environment;social influence;social norm;Solid;South Asian;System;Targeted Research;Testing;Time;White Women;Woman;women of color

PROJECT_TITLE: Policy levers to reduce racial-ethnic inequities in diabetes after gestational diabetes

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BLACKSBURG

ORG_DEPT: NEUROSCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Temperature profoundly influences animal biology. In Drosophila melanogaster, the GR28B(D) gustatory receptor acts as a warm receptor in heating cells, but the molecular basis of its temperature sensing remains unclear. This proposal aims to examine the molecular domains responsible for temperature sensing of GR28B(D).

PI_NAMEs: HUDA, AINUL  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Adopted;Affect;Afferent Neurons;Amino Acids;Animals;Behavior;Behavioral;Biological Assay;Biology;Calcium;career;Cells;chemical reaction;Chimeric Proteins;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cold temperature;CRISPR/Cas technology;Cryoelectron Microscopy;Cues;Culicidae;Cytosine;Deamination;Dengue;Development;disease transmission;Disease Vectors;DNA Repair;Drosophila genus;Drosophila melanogaster;Electrophysiology (science);Equilibrium;Esthesia;Exons;experimental study;Family;Fellowship;fly;Genes;Genetic;genetic manipulation;Heating;High temperature of physical object;Image;In Vitro;in vivo;Individual;innovation;Insecta;insight;Integral Membrane Protein;Invertebrates;Ion Channel;Journals;Laboratories;Ligand Binding;Malaria;Methodology;Modeling;Molecular;molecular domain;mutant;Names;neural;Neurons;Nucleic Acid Regulatory Sequences;olfactory receptor;Organism;Physiological;Physiological Processes;Play;Point Mutation;Process;Proteins;Reaction;receptor;Reproduction;Research;Research Personnel;response;RNA Splicing;Role;Saponins;Sensory Process;Shapes;Structure;Study models;Sucrose;symposium;System;Taste Perception;Techniques;Temperature;Temperature Sense;Tertiary Protein Structure;Testing;Thermoreceptors;tool;Training;Transmembrane Domain;Variant;vector control;Vector-transmitted infectious disease;Virginia

PROJECT_TITLE: Understanding the Molecular Mechanisms of Thermoreceptors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ADMINISTERING_IC: CA

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Project Narrative Osteosarcoma is a devastating and highly metastatic bone cancer that causes pain and mortality and histotripsy, a novel ablation modality using high-intensity focused ultrasound, shows promise in both destruction of the primary tumor and induction of an anti-tumor immune response to combat metastatic disease. Our group has validated the safety & feasibility of ablating portions of osteosarcoma tumors with histotripsy, but crucial studies investigating the required treatment parameters and the clinical outcomes of complete ablation of osteosarcoma are needed to further the clinical translation of histotripsy for the treatment of bone tumors. My proposal tackles these questions in order to assess the safety & feasibility of histotripsy for the complete ablation of osteosarcoma.

PI_NAMEs: VICKERS, ELLIANA ROSE (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Ablation;Acoustics;Acute;Address;Affect;Amputation;Anesthetics;anti-tumor immune response;arm;Biomedical Engineering;Bone neoplasms;Cancer Etiology;Canis familiaris;Cessation of life;chemotherapy;Chronic;Client;Clinical;Clinical Oncology;clinical translation;Clinical Trials;college;combat;comparative;Complication;contrast enhanced;Data;Detection;Development;Device or Instrument Development;Disease;Dose;Engineering;Evaluation;experience;experimental study;Feedback;Focused Ultrasound;Focused Ultrasound Therapy;follow-up;Frequencies;Future;Gait;gait examination;Human;improved;in vivo;Incidence;Intervention;invention;Knowledge;limb amputation;Limb Salvage;Limb structure;Longterm Follow-up;Magnetic Resonance Imaging;Maryland;Mechanics;member;Mentors;Metastatic Neoplasm to the Bone;Michigan;Mobility decline;Modality;Modeling;Molecular;Monitor;mortality;Nature;Neoplasm Metastasis;novel;Oncology;Operative Surgical Procedures;Osteosarcoma;Outcome;Pain;Patients;Perfusion;Physiologic pulse;Physiological;Pilot Projects;pressure;primary bone cancer;Primary Neoplasm;Productivity;Publishing;Quality of life;Questionnaires;radiologist;Radiology Specialty;recruit;Research;Resected;Robotics;Safety;safety and feasibility;safety assessment;skills;standard of care;Survival Rate;System;Teaching Hospitals;Techniques;Technology;Testing;Time;Tissues;Training;Transducers;transmission process;treatment strategy;tumor;tumor ablation;Universities;Veterinary Medicine;Virginia;Wisconsin;Work

PROJECT_TITLE: Investigating treatment strategies & clinical outcomes of histotripsy for complete ablation of osteosarcoma


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Climate-Related Exposures and Conditions;Eye Disease and Disorders of Vision;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative Recent epidemiologic studies indicate that outdoor air pollution is associated with increased incidence of AMD, glaucoma and altered retinal thickness. The objectives of this study are to characterize how air pollution affects the molecular, functional and morphologic phenotypes of normal and disease-susceptible and aged retinas, identify intrinsic tissue protective responses induced by air pollution, and determine the extent that air pollution contributes to retinal pathology. This study will provide new mechanistic insights into how air pollution contributes to retinal disease, and will identify potential targets for therapeutic intervention.

PI_NAMEs: HACKAM, ABIGAIL S (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acceleration;Acute;Address;aerosolized;Affect;Age;age effect;aged;Aging;Air Pollutants;Air Pollution;ambient air pollution;Animal Housing;Animal Model;Animals;Apoptosis;Area;arteriole;Behavior;Bioinformatics;biological adaptation to stress;Biological Assay;Blindness;Blood Vessels;blood-brain barrier crossing;burden of illness;Cardiovascular Diseases;Caspase;Cell Death;cell injury;Cellular Stress;Cessation of life;Chronic;Circulation;climate change;Cornea;Custom;cytokine;design;Disease susceptibility;DNA Damage;Drug Metabolic Detoxication;Environmental Health;Environmental Pollution;Environmental Risk Factor;epidemiology study;Exposure to;Eye;Eye diseases;fine particles;Flow Cytometry;Future;Genes;Glaucoma;Goals;Health;Histology;Incidence;Inflammation;Inflammatory;Inhalation;insight;Knowledge;Lung Diseases;Measures;Mitochondria;Modeling;Molecular;Molecular Analysis;Morphology;mouse model;Mus;nanoparticle;Natural History;Nervous System Disorder;neuroinflammation;Oxidative Stress;Oxidative Stress Induction;Oxides;particle;Particulate Matter;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phenotype;pollutant;Pollution;Predisposition;Publishing;Qualifying;Reproducibility;Research;response;Retina;retinal damage;Retinal Diseases;Risk;Risk Factors;Role;single-cell RNA sequencing;System;targeted treatment;Testing;Therapeutic Intervention;Thick;Time;Tissues;Toxic effect;Vision;Wild Type Mouse;Wildfire

PROJECT_TITLE: Modeling the effect of outdoor air pollution on the health and function of the retina

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Comparative Effectiveness Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative Approximately one decade ago, physicians called for further research examining the effects of antipsychotic medications on youth. Yet, there is a strong consensus that the effects of these treatments on the diverse population receiving them remain unknown. This proposal will produce knowledge that will inform clinical decision making by robustly examining the current pediatric population receiving antipsychotics and the effectiveness of antipsychotic medications compared to alternate medication options.

PI_NAMEs: SEPE-FORREST, LINNEA  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: 17 year old;active comparator;Address;Affect;alternative treatment;anti-depressive agents;Antipsychotic Agents;aripiprazole;Attention deficit hyperactivity disorder;autism spectrum disorder;career;Characteristics;Childhood;Clinical;clinical decision-making;Clinical Trials;comparative effectiveness;Comparative Study;compare effectiveness;Consensus;cost outcomes;Data Mart;Data Set;Demographic Factors;Depressive disorder;design;Development;Diagnosis;Diagnostic;Disease;Disparity;Effectiveness;effectiveness evaluation;Ensure;Ethnic Origin;Event;Exclusion;Exhibits;experience;Goals;Government;Government regulations;Health;Health Professional;Healthcare;high risk;Hospitalization;hospitalization rates;improved;Individual;innovation;inpatient psychiatric treatment;insight;Knowledge;Label;large scale data;Low income;Medicaid;Mental Depression;Metabolic;Methods;minority children;neglect;Neurologic;Outcome;Patients;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacotherapy;Physicians;Physiological;Policies;Population;Population Heterogeneity;Predictive Factor;programs;protective effect;Psychiatric Diagnosis;psychologic;psychological symptom;Psychoses;Public Health;Race;racial difference;racial disparity;Reporting;Research;Risk;Risperidone;Sampling;Schizophrenia;Scoring Method;Socioeconomic Status;Stimulant;Subgroup;Survival Analysis;Symptoms;Testing;Training;treatment disparity;treatment effect;United States;Work;Youth

PROJECT_TITLE: Real-world, national evidence on the predictors and consequences of pediatric antipsychotic use


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Sexually reproducing organisms rely on meiosis, a specialized cell division that generates haploid gametes to ensure the correct inheritance of genomes from parent to offspring. Defects in this process result in gametes with an incorrect number of chromosomes or aneuploidy, which is the primary cause of age-related infertility, miscarriages, and genetic disorders, such as Down Syndrome. My proposed research will elucidate regulatory mechanisms that ensure the faithful transmission of genetic information and will broadly impact the field of reproductive biology and the design of therapeutic interventions.

PI_NAMEs: CESAR-HERNANDEZ, BRENDA I (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;Affect;age related;Aneuploidy;Appearance;Architecture;Area;Bacteria;Bacterial Proteins;Behavior;biophysical properties;Caenorhabditis elegans;Cell division;Chromatin;chromosome number abnormality;Chromosome Pairing;Chromosome Segregation;Chromosomes;Coiled-Coil Domain;Complex;Congenital Disorders;Coupled;crosslink;Data;Defect;design;Diffusion;Diploid Cells;Down's Syndrome;Elements;Ensure;Eukaryota;Exhibits;F Box Domain;Foundations;Genetic;Genetic Crossing Over;Genetic Diseases;genetic information;Genetic Variation;Genome;Germ Cells;Germ Lines;Haploidy;Higher Order Chromatin Structure;Homologous Gene;homologous recombination;impression;In Vitro;in vivo;Infertility;insight;Lateral;Lead;Length;light scattering;Link;Liquid substance;Maps;Mass Spectrum Analysis;Meiosis;Meiotic Prophase I;model organism;Molecular;Molecular Sieve Chromatography;Molecular Weight;Nematoda;offspring;Organism;Parents;Phase;Photometry;Physical condensation;Play;Positioning Attribute;Process;Production;Property;Prophase;protein complex;protein expression;protein protein interaction;protein purification;Protein Region;protein structure;Proteins;reconstitution;Reproductive Biology;Research;Role;Sampling;scaffold;segregation;Sexual Reproduction;Spontaneous abortion;stoichiometry;Stretching;Structure;Synapses;Synaptonemal Complex;Syp protein;System;Tertiary Protein Structure;Therapeutic Intervention;transmission process;ubiquitin ligase;Work

PROJECT_TITLE: In vitro Reconstitution of the C. elegans Synaptonemal Complex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04B-S (20)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Vaccine Related

ORG_CITY: BIRMINGHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Streptococcus pneumoniae is a Gram-positive bacterium that resides in the nasopharynx and can cause opportunistic infections such as pneumonia, bacteremia, and meningitis. The proposed research will investigate how repeated exposure events to S. pneumoniae biofilms during colonization leads to proinflammatory damage to the nasal epithelia and the development of a humoral immune response. Findings from this work will extend our knowledge of S. pneumoniae biology and its pathogenesis while potentially identifying novel antigens appropriate for next-generation vaccines.

PI_NAMEs: LANE, JESSICA R (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: acquired immunity;adaptive immune response;Adaptive Immune System;adaptive immunity;Adult;Animals;Antibodies;Antibody Formation;Antibody Response;Antibody Therapy;Antibody titer measurement;Antigens;Bacteremia;Bacteria;Basement membrane;Binding;Biological;Biology;capsule;Cell Death;Cells;Cessation of life;Child;cytokine;Data;Desiccation;Development;Disease;Epithelial Cells;Epithelium;Event;Exposure to;Gene Expression;Generations;Gram-Positive Bacteria;high resolution imaging;Histologic;Host Defense Mechanism;Human;human disease;Image;Immune;immune cell infiltrate;Immune response;Immunity;Immunization;infancy;Inflammatory;innovation;Knowledge;Measures;Meningitis;Microbial Biofilms;Microscopy;Modeling;Morphology;mouse model;Mucous body substance;Mucous Membrane;Mus;Nasal Epithelium;Nasopharynx;Natural Immunity;Nose;novel;novel vaccines;Nutrient;Opportunistic Infections;Organoids;Otitis Media;Outcome;pathobiont;pathogen;Pathogenesis;Pathologic;Phenotype;Pneumococcal Colonization;pneumococcal surface protein A;Pneumonia;Polysaccharides;Prevalence;Proteins;Research;respiratory;Scanning Electron Microscopy;Serotyping;Shapes;Streptococcus pneumoniae;Streptococcus pneumoniae plY protein;Testing;Toxin;transmission process;Upper respiratory tract;Vaccines;Work

PROJECT_TITLE: Biofilm antigens drive natural immunity to Streptococcus pneumoniae.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Immunotherapy;Infectious Diseases;Inflammatory Bowel Disease

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Specific types of T helper cells are necessary for effective immune defense against pathogens but can also cause problems such as inflammatory bowel disease. Emerging evidence indicates that nutrient metabolism inside T cells can influence their development and function, but which metabolites and metabolic pathways are involved remains poorly understood. The proposed research seeks to determine whether manipulating a metabolite called L-2-hydroxyglutarate can enhance protective T helper cell responses and inhibit destructive T helper cells.

PI_NAMEs: MCNAMARA, THOMAS FRANCIS (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute Myelocytic Leukemia;alpha ketoglutarate;Anti-Inflammatory Agents;Autoimmune;Autoimmune Diseases;Autoimmunity;Bacteria;Bacterial Infections;Biochemical Reaction;cancer cell;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cell Fate Control;Cell Physiology;Cells;Cellular Metabolic Process;chiral molecule;Chromatin Remodeling Factor;Chromatin Structure;Citrobacter rodentium;Clonal Expansion;Colitis;Couples;Cues;cytokine;Data;Development;DNA;enantiomer;engineered T cells;Enzymes;Epithelial Cells;Equilibrium;extracellular;Gene Expression;Genes;genetic manipulation;Genetically Engineered Mouse;Helminths;Helper-Inducer T-Lymphocyte;histone demethylase;Histones;Host Defense;Human;Hydrogen Sulfide;Hypoxia;Hypoxia Inducible Factor;Image;Immune;Immune response;immunopathology;immunoregulation;Impairment;In Vitro;in vivo;Infection;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;inhibitor;insight;intestinal epithelium;Intestines;Investigation;Isocitrate Dehydrogenase;Malignant Neoplasms;Mediating;Memory;Metabolic;Metabolic Control;Metabolic Pathway;metabolic phenotype;Metabolism;mitochondrial metabolism;Modeling;Molecular;mutant;Mutation;Normal Cell;novel;novel strategies;novel therapeutic intervention;nutrient metabolism;pathogen;Pathogenesis;Physiological;Production;programs;Regulatory T-Lymphocyte;Reporting;Research;response;Role;sensor;Signal Transduction;Somatic Mutation;Source;Stereoisomer;T cell differentiation;T-Lymphocyte;Testing;Tissues;transcription factor;tumor-immune system interactions;virtual

PROJECT_TITLE: Investigating the role of L-2-hydroxyglutarate in helper T cell differentiation and function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The brain microenvironment is highly immunosuppressive in glioblastoma (GBM), which is the most common primary brain tumor in the United States with a dismal prognosis of approximately one-year post-diagnosis. While aberrant epidermal growth factor receptor (EGFR) activation is associated with a distinct myeloid phenotype, the precise mechanism by which this oncogenic signaling axis impairs anti-tumor immune response is poorly understood. This proposal will identify an important tumor-immune crosstalk mechanism driven by EGFR activation, allowing for a deeper mechanistic understanding of immunosuppression in GBM and potential targets to improve anti-tumor immune response.

PI_NAMEs: PIOSO, MARISSA S (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Ablation;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;antigen-specific T cells;Antigens;Astrocytes;Bioinformatics;Biological Assay;Brain;Brain Neoplasms;cancer infiltrating T cells;cell killing;Cell Physiology;Cell Separation;cell type;Cephalic;Chronic;Clinical;clinical efficacy;clinical prognosis;Clonality;Coculture Techniques;combinatorial;comparative efficacy;Complex;Cytometry;Cytotoxic T-Lymphocytes;cytotoxicity;Data;design;Development;Diagnosis;Disease;effector T cell;engineered T cells;Engineering;Environment;Epidermal Growth Factor Receptor;exhaust;exhaustion;experience;Experimental Designs;Functional disorder;Funding;Gene Expression;Genetic;Glioblastoma;Glioma;Goals;Immune;immune cell infiltrate;immune checkpoint blockade;Immune Evasion;Immune response;Immunocompetent;Immunofluorescence Immunologic;Immunooncology;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Impairment;improved;In Vitro;in vivo;Inferior;Inflammation;Inflammatory;innovation;insight;Interleukin-1 beta;Interleukin-6;Intervention;knock-down;Knowledge;Lead;Link;loss of function;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mentors;Microglia;Modality;Modeling;mouse model;multidisciplinary;Multiple Sclerosis;Mus;mutant;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;Newly Diagnosed;novel;novel strategies;Oncogenes;Oncogenic;Patient-Focused Outcomes;Patients;PD-1 blockade;pharmacologic;Phenotype;polarized cell;Population;Primary Brain Neoplasms;progenitor;Prognosis;Proliferating;Receptor Activation;Receptor Cross-Talk;Receptor Inhibition;Receptor Signaling;Role;Sampling;Signal Transduction;single cell analysis;small molecule inhibitor;success;survival outcome;synergism;System;T cell infiltration;T cell response;T-Lymphocyte;targeted agent;Tetracyclines;Therapeutic;therapeutically effective;Training;Transforming Growth Factor beta;translational scientist;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;United States;Vascular Endothelial Growth Factors;Work;wound healing

PROJECT_TITLE: Aberrant activation of epidermal growth factor receptor signaling drives programming of an immunosuppressive brain tumor microenvironment in glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome

ORG_CITY: ATLANTA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Atherosclerosis, the leading cause of death worldwide, develops in response to disturbed flow and hypercholesterolemia. In this study, we propose to investigate the effects of disturbed flow alone, hypercholesterolemia alone, and the plaque-inducing combination of disturbed flow and hypercholesterolemia on arterial cell reprogramming, especially flow-induced reprogramming of endothelial cells (FIRE), and screen for novel gene targets for atherosclerosis. Our study is designed for better understanding of the pathophysiological mechanisms of atherogenesis and identification of novel therapeutic targets to combat this widespread and lethal disease.

PI_NAMEs: PARK, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;Animals;Antiatherogenic;aortic arch;Arterial Fatty Streak;Arteries;atherogenesis;Atherosclerosis;biomarker validation;Biomechanics;biomedical scientist;Blood;Blood flow;Cardiovascular system;Carotid Arteries;Cause of Death;Cell Communication;Cell Reprogramming;cell type;Cells;Cholesterol;Chronic;chronic inflammatory disease;combat;Common carotid artery;Contralateral;Coronary artery;Cues;Data Analyses;Data Set;design;Development;Disease;Endothelial Cells;Endothelium;Engineering;Exposure to;Fibroblasts;Foam Cells;Functional disorder;gene regulatory network;Gene Targeting;Genes;genome-wide;Goals;Human;hypercholesterolemia;Immune;Inflammation;innovation;insight;Ischemic Stroke;knock-down;Knowledge;Left;Ligation;Macrophage;Mediating;Mentorship;Mesenchymal;Methods;Microbubbles;Modeling;mortality;mouse model;Mus;Myocardial Infarction;new therapeutic target;novel;novel therapeutics;overexpression;Pathway Analysis;Pathway interactions;Peripheral arterial disease;Prevention;Research Personnel;response;Risk Factors;Role;single cell ATAC-seq;single-cell RNA sequencing;Smooth Muscle Myocytes;success;targeted treatment;Testing;Therapeutic;therapy development;Tissue-Specific Gene Expression;Training;transcriptomics;Transgenes;ultrasound;Universities;Vascular Smooth Muscle

PROJECT_TITLE: Arterial Cell Reprogramming by Disturbed Flow and Hypercholesterolemia


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Adding to the growing evidence of impaired proteostasis as a cellular hallmark of cardiac disease, Endoplasmic Reticulum stress, protein aggregation, and activation of the Unfolded Protein Response (UPR) have been identified in a genetically inherited form of Dilated Cardiomyopathy (DCM). Pharmacological activation of the UPR alleviates ER stress and rescues impaired contractility in DCM cardiomyocytes. Understanding the mechanism of how UPR bolstering improves DCM phenotypes will identify new therapeutic targets to treat the cell stress in the cardiomyocyte that underlies DCM.

PI_NAMEs: BAUM, RACHEL  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: activating transcription factor 4;BAG3 gene;biological adaptation to stress;Biological Assay;Calcium Signaling;Cardiac;Cardiac Myocytes;Cell Line;Cells;Cellular Stress;chromatin immunoprecipitation;cohort;CRISPR/Cas technology;Cytoskeleton;Data;Defect;Desmosomes;Development;Dilated Cardiomyopathy;Disease;disease model;endoplasmic reticulum stress;Exhibits;experimental study;Failure;Functional disorder;Gene Mutation;gene therapy;Genes;Genetic;Genetic Models;Genetic Transcription;genome editing;Genotype;Goals;Heart;Heart Diseases;Heart failure;heart function;Human;Impairment;improved;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inherited;Ions;knock-down;Left;Link;Mediating;Mediator;misfolded protein;Mitochondria;Molecular;mouse model;Mutation;Myocardial dysfunction;new therapeutic target;novel;Ontology;overexpression;Pathogenesis;Pathologic Processes;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;pharmacologic;Phenocopy;Phenotype;phospholamban;Play;Prevalence;protein aggregation;protein misfolding;Proteins;proteostasis;proteostasis loss;Pump;Reaction;Research;response;RNA Interference;Role;Signal Pathway;Signal Transduction;small molecule;Source;sudden cardiac death;Testing;Therapeutic;therapeutic target;tool;transcription factor;Translating;Up-Regulation;Variant;Ventricular;Work

PROJECT_TITLE: Investigating the role of the Unfolded Protein Response in Genetic Dilated Cardiomyopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (20)]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: GABORONE

ORG_COUNTRY: BOTSWANA

ORG_FIPS: BC

ORG_NAME: BOTSWANA-HARVARD AIDS INSTITUTE

PHR: Project Narrative In Botswana, many adolescents and young adults have received continuous ART for nearly two decades and are ideal candidates for research into functional HIV cure. In this K43 application, I propose to assess a cohort of early-treated adolescents by carrying out an in-depth characterization of their proviral reservoir, assessing mechanisms of possible viral control, evaluate how the reservoir evolves in this cohort of adolescents while I leverage an existing U01- supported analytic treatment interruption protocol (U01AI179561) for selected participants (enrolling those with a blocked and locked reservoir profile), and finally identify potential markers of functional cure. This award will help me develop research skills and advanced laboratory techniques for HIV cure research in Botswana and prepare me to conduct independent research.

PI_NAMEs: KOOFHETHILE, CATHERINE KEGAKILWE (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adolescence;Adolescent;Adolescent and Young Adult;Africa;Aftercare;Agreement;antiretroviral therapy;Award;Bachelor's Degree;Biological Assay;Biological Markers;biomarker identification;Botswana;career development;CD4 Positive T Lymphocytes;Child;Childhood;chromosomal location;Clinical;clinical investigation;Clonal Expansion;Clonality;cohort;Country;Development;DNA;Doctor of Philosophy;Eligibility Determination;Enrollment;Enzyme-Linked Immunosorbent Assay;Evaluation;experience;Failure;Fellowship;follow-up;Frequencies;Funding;Future;Genome;Goals;Health;HIV;HIV-1;HIV-infected adolescents;Home;Immunology;Individual;Infection;integration site;International;Interruption;Intervention;Journals;Laboratories;Lead;Length;Life;Master of Science;Medical Microbiology;medical schools;Mentors;Mentorship;Modeling;next generation sequencing;novel;Participant;pathogen genomics;Pathway interactions;Pattern;pediatric human immunodeficiency virus;Perinatal;Peripheral Blood Mononuclear Cell;Postdoctoral Fellow;Process;programs;Protocols documentation;Proviruses;Public Health Schools;Publishing;Research;Research Personnel;RNA;Sequence Analysis;Serology;skills;statistics;success;Techniques;Testing;Time;Training;trend;United States National Institutes of Health;Viral;viral rebound;Viremia;virology;Virus;young adult

PROJECT_TITLE: Finding a pathway to HIV cure among adolescents on long-standing ART in Botswana through reservoir analysis, analytic treatment interruption, and biomarker assessment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICP-P (55)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Precision Medicine;Rural Health;Social Determinants of Health

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: PROJECT NARRATIVE The primary objective of this research project is to evaluate the potential value of pharmacogenetics (PGx) implementation in Montana and assess the clinical uptake of PGx with a specific focus on rural and underserved communities. The project aims to assess the prescribing patterns of PGx medications in rural and underserved settings, and gather insights into the clinical utility of PGx among healthcare providers. We will utilize results to build knowledge on implementating gene-guided prescribing into standard healthcare practices, fostering a paradigm shift towards personalized and equitable treatment approaches.

PI_NAMEs: KILLAM, SHAYNA RAE (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Academic Medical Centers;access disparities;Area;Bioinformatics;Biometry;burden of illness;Cardiology;career;Caring;Centers for Population Health;Clinical;Communicable Diseases;Community Health;Consultations;cost effectiveness;Data;Data Collection;Data Science;data visualization;demographics;Development;Diffusion;Dose;Drug Prescriptions;Electronic Health Record;Ensure;Equity;evidence base;experience;Extramural Activities;Fellowship;Fostering;Foundations;Frequencies;Funding;Future;Genes;genetic variant;Geographic Locations;Geography;Goals;graduate student;Growth;Health;health care disparity;health data;health disparity;health equity;Health Personnel;health professional shortage areas;Health system;Health Technology;Healthcare;Healthcare Systems;implementation efforts;implementation science;implementation strategy;Improve Access;improved;Indigenous;indigenous community;Inequity;innovation;insight;Instruction;K-Series Research Career Programs;Knowledge;Left;Location;marginalized community;medical specialties;meetings;Mental Health;metropolitan;Montana;Outcome;Outcomes Research;Pain management;patient population;Patients;Pattern;personalized approach;Pharmaceutical Preparations;pharmacogenetic testing;Pharmacogenetics;Pharmacotherapy;Pharmacy Students;Postdoctoral Fellow;practice setting;prevent;Primary Health Care;programs;Provider;Recommendation;Research;Research Personnel;Research Project Grants;Resources;response;Rural;rural area;Rural Community;rural setting;Secure;side effect;socioeconomic disadvantage;Socioeconomic Status;socioeconomics;Students;Supervision;Surveys;telehealth;Therapeutic;Training;Tribes;underserved area;underserved community;Underserved Population;United States National Institutes of Health;Universities;uptake;Urban Community;vulnerable community

PROJECT_TITLE: Ensuring Equity in Pharmacogenetics for Rural and Underserved Communities


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: Inflammation and infection induce cells called osteoclasts that cause pathologic bone loss. The goals of this project are to understand mechanisms that induce excessive bone loss and promote persistence of Staphyloccocus aureus periprosthetic joint infection (PJI). We anticipate that our studies will provide knowledge that can be used to develop new therapies to suppress bone resorption and to develop adjuvant immunotherapies to help clear PJI.

PI_NAMEs: IVASHKIV, LIONEL B (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: adaptive immune response;adaptive immunity;Adjuvant;Arthritis;Attenuated;bone;bone erosion;bone loss;Bone Marrow;Bone remodeling;Bone Resorption;Cell Lineage;Cell Physiology;Cells;clinically relevant;Complication;conditioning;Coupled;cytokine;Development;Disease;Distal;Epigenetic Process;Failure;Feedback;Gene Expression;Gene Expression Profile;Generations;Genes;Goals;Hypoxia;Immune;Immunity;Immunotherapy;Implant;Infection;Infiltration;Inflammation;Inflammatory;inflammatory bone loss;inhibitor;Interferons;Interleukin-1;interleukin-23;Knowledge;Ligands;Link;Literature;Mediating;Medical;Metabolic;Microbial Biofilms;Modeling;Molecular;Morbidity - disease rate;mortality;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Myeloid-derived suppressor cells;Myelopoiesis;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Orthopedics;osseointegrated implant;Osseointegration;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;Osteolysis;Pain;Pathologic;pathologic bone resorption;Pathway interactions;peri-implant bone loss;Periprosthetic joint infection;Phenotype;Physiological;Population;preconditioning;programmed cell death protein 1;programs;receptor;Regulation;Replacement Arthroplasty;Resistance;response;Rheumatoid Arthritis;S phase;Signal Transduction;Site;skeletal;soft tissue;Staphylococcus aureus;Staphylococcus aureus infection;STAT1 gene;T-Cell Proliferation;T-Lymphocyte;Testing;Time;Tissues;TNF gene;TNFSF11 gene;Training;Work

PROJECT_TITLE: Negative Regulation of Osteoclastogenesis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


PHR: Project Narrative Metastases form in a wide range of target organs that vary not only in their chemical composition but also in their biophysical properties. We have found that patrolling immune cells preferentially engage and selectively destroy stiffer cancer cells and that cancer cells mimic the stiffness of their environment. Our proposed studies will investigate if and how the rigidity of the metastatic microenvironment influences the stiffness dependent killing of cancer cells and, by extension, whether the interplay between tissue mechanics and immune function effectively dictates where metastasis grows, a process otherwise known as metastatic site preference.

PI_NAMEs: ELBANNA, YASSMIN  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Affect;Atomic Force Microscopy;Biochemical;bioluminescence imaging;biomarker identification;Biomechanics;biophysical analysis;Biophysical Process;biophysical properties;Biophysics;bone;cancer cell;Cancer Cell Growth;Cancer Control;Candidate Disease Gene;cell transformation;Cells;Cellular biology;Cellular Immunology;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Cues;cytotoxic;Cytotoxic T-Lymphocytes;Data;Development;Discrimination;Environment;epidural space;Exhibits;fighting;Genes;Genetic;Goals;Growth;Health;Histologic;Histology;Human;Immune;immune checkpoint blockade;immune function;Immune response;immunodeficiency;Immunological Models;Immunology;Immunotherapy;Implant;In Vitro;in vivo;in vivo Model;innovation;Institution;interest;Knock-out;Knowledge;Laboratories;Lung;Lymphocyte;Malignant Neoplasms;Mechanics;Mediating;Metastatic Neoplasm to the Bone;Metastatic Neoplasm to the Lung;Methods;Molecular;mouse model;Mus;Natural Killer Cells;neoplasm immunotherapy;Neoplasm Metastasis;novel;novel strategies;Operative Surgical Procedures;Organ;osteopontin;Pathway interactions;polyacrylamide;Positioning Attribute;preference;pressure;Process;Prognostic Marker;Property;Proteoglycan;Role;Sampling;Shapes;single-cell RNA sequencing;Site;Spinal;subcutaneous;success;Surface;System;T-Lymphocyte and Natural Killer Cell;Technology;Tissues;Training;transcriptomics;vertebra body;Vertebral column

PROJECT_TITLE: A Mechanoimmunological Basis for Metastatic Site Preference


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: PITTSBURGH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Almost 30% of people will experience a voice problem in their lifetime, with associated negative consequences in economic stress, productivity, and quality of life. Cellular repair and response to injury in the vocal folds has shown key differences in molecular composition of disordered phenotypes including vocal fold scar, indicating a strong rationale for investigation of gene influence on the mechanisms of vocal fold repair. This proposal seeks to elucidate the transcript-level changes that occur in vocal fold scar within a fibrosis-associated pathway, TGF-β (transforming growth factor beta), to inform preclinical innovation and new therapeutic targets.

PI_NAMEs: HARY, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Animals;Asthma;Automobile Driving;Basic Science;Bioinformatics;Biological Assay;Biomedical Research;career;Cell Death;Cell Line;Cells;Cicatrix;Clinical;clinical biomarkers;Clinical Data;Collagen;Collagen Type IV;Communication;comparative;comparison control;Complex;cost estimate;Data;data integration;Data Set;Deposition;design;Development;Diabetes Mellitus;Direct Costs;disability;Disease;doctoral student;Economics;Employment;Environment;Epithelial Cells;Epithelium;Etiology;experience;Extracellular Matrix;Fibroblasts;fibromodulin;Fibronectins;Fibrosis;Foundations;Future;Genes;Genetic;genetic approach;genetic effector;Genetic Transcription;Goals;Health Care Costs;Healthcare;healthcare burden;Human;human subject;Iatrogenesis;Immunofluorescence Immunologic;Immunohistochemistry;Impairment;In Vitro;in vitro Model;in vivo;Individual;Injury;innovation;Investigation;Knowledge;Label;Larynx;Leadership;Link;Mediating;Mentorship;Modality;Modeling;Molecular;Molecular Biology;multidisciplinary;multimodality;Myofibroblast;new therapeutic target;novel;Operative Surgical Procedures;Oryctolagus cuniculus;overexpression;Pathway interactions;Patients;Pattern;Persons;Phase;Phenotype;Play;Population;pre-clinical;pre-doctoral;Procedures;Process;Production;Productivity;Professional Competence;programs;Proliferating;Proteins;Pulmonary Fibrosis;Quality of life;re-epithelialization;repaired;Research;Research Design;Research Personnel;response to injury;Role;Sampling;Science;Signal Pathway;Site;skills;skin wound;Speech-Language Pathology;Speed;Stains;Stratified Squamous Epithelium;Stress;Surgical Models;Techniques;therapy development;Time;Tissues;Training;Transcript;transcriptome sequencing;Transforming Growth Factor beta;Transforming Growth Factor-Beta Overexpression;Translations;Treatment outcome;treatment strategy;Up-Regulation;vector;vibration;vocal cord;Voice;Voice Disorders;Western Blotting;Work;wound healing

PROJECT_TITLE: Genetic pathways that contribute to fibrosis in iatrogenic vocal fold scar

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (35)]


NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project narrative The central purpose of our project is to identify and understand the mechanism by which JAK2V617F creates a competitive advantage for outgrowth in haematopoietic stem cells (HSC) in MPN patients that exhibit dampened IL-10R signalling response. In using diverse cell signalling analysis techniques in western blot, co- immunoprecipitation, and phosphoflowcytometry we will be able to effectively interrogate the transformative effect of the mutant JAK2V617F on IL-10R signalling in a non-canon context. Our research in this project will shed light on the non-canonical mechanisms by which mutant JAK2V617F is able to diversify cell signalling for abhorrent proliferation and differentiation of HSCs.

PI_NAMEs: WADLEY, WILLIAM LUCAS PAREDES (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: Ablation;B-Lymphocytes;Back;Biological Assay;Blocking Antibodies;Blood;Cell Line;cell type;Cells;Chronic;Clonal Expansion;Clonal Hematopoietic Stem Cell;Co-Immunoprecipitations;Compensation;cytokine;Cytokine Receptors;Cytometry;Data;Defect;Dependence;Disease;Disease Progression;Environment;Exhibits;experimental study;Fibroblasts;fighting;Genetic;Growth;Growth Factor Receptors;Hematological Disease;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;Heterodimerization;Human;Immunoprecipitation;Inferior;Inflammation;Inflammatory;inhibitor;Interferon alpha;interferon alpha receptor;Interleukin-10;JAK1 gene;JAK2 gene;knock-down;Knock-in Mouse;Knockout Mice;Lesion;Link;Measures;Mediating;monocyte;Mus;mutant;Mutation;Myelogenous;Myeloid Cells;Myeloproliferative disease;new therapeutic target;Normalcy;novel;Pathway interactions;Patients;Persons;Phenotype;Phosphotransferases;Population;Predisposition;pressure;Production;Proliferating;Research;Resistance;response;Role;Signal Induction;Signal Pathway;Signal Transduction;small hairpin RNA;Small Interfering RNA;Somatic Mutation;stable cell line;stem cell exhaustion;Stimulus;Stress;Techniques;Testing;TNF gene;Transactivation;Transplantation;Twin Multiple Birth;Western Blotting;Withdrawal

PROJECT_TITLE: JAK2V617F transactivation of JAK1 mediates constitutive activation of IL-10R signaling


NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

PHR: PROJECT NARRATIVE Trichomonas vaginalis is a protozoan parasite that causes the most common non-viral sexually transmitted infection worldwide and has an unusually high detection rate in older women. Drug resistant strains of T. vaginalis are increasing, and the parasite is associated with myriad reproductive complications, and increased incidences of HIV infection, cervical cancer, and prostate cancer. The proposed study aims to elucidate how T. vaginalis subverts immune responses specific to the female reproductive tract to establish pathogenesis in order to inform therapeutic interventions.

PI_NAMEs: KOCHANOWSKY, JOSHUA ANDREW (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Address;Adherence;Affect;Biological Assay;Bite;Caveolins;Cell Communication;Cell Death;cell killing;cell motility;Cell Survival;Cells;Chemicals;clinically relevant;Contracts;cytokine;Cytolysis;Data;Detection;Drug resistance;Endocytosis;Environment;Epithelial Cells;extracellular;extracellular vesicles;Fellowship;female reproductive tract;Future;Genes;Health;HIV;HIV Infections;Human;Immune;Immune response;Incidence;Infection;Inflammation;inhibitor;Innate Immune Response;insight;Interferon Type I;Interferons;Knowledge;Link;male;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Mediating;Membrane Microdomains;Molecular;Mucous Membrane;neutrophil;Nutrient;older women;Outcome;Parasites;Parasitic infection;pathogen;Pathogenesis;Pathology;Pathway interactions;Perimenopause;Persons;Play;Postmenopause;Predisposition;Pregnancy Complications;prevent;Process;programs;Property;Prostate;Proteins;reproductive;Research;resistant strain;response;Role;seropositive;Sexually Transmitted Diseases;Signal Transduction;small molecule;Small RNA;Testing;Therapeutic Intervention;therapeutic target;transcriptome sequencing;Trichomonas Infections;Trichomonas vaginalis;United States;uptake;urogenital tract;Vagina;vaginal infection;Vaginitis;Viral;Western Blotting;Woman;Work

PROJECT_TITLE: Elucidating the role of IFN epsilon mediated type I IFN responses against Trichomonas vaginalis


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Chagas' disease is a severely neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, for which treatments are inadequate and no vaccine exists. During its lifecycle, the parasite undergoes dramatic morphological changes between the insect and mammalian hosts which likely contribute to its success as a pathogen. In this proposal, I aim to describe the molecular drivers of one of these morphological transitions known as metacyclogenesis by combining [transcriptomics and high resolution imaging techniques, which will allow for the identification of targets for transmission blocking].

PI_NAMEs: KEROACK, CAROLINE DANA (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Area;Benznidazole;Biological;Biology;biomarker identification;Blood;Blood Circulation;Candidate Disease Gene;Cell Cycle;Cell Cycle Progression;Cell Differentiation process;Cell division;Cells;Cellular Morphology;Central America;Cessation of life;Chagas Disease;Chronic;combat;Complement;Complex;CRISPR/Cas technology;Cytolysis;Cytoplasm;Data;drug development;Drug Targeting;Endocytosis;Environment;Essential Genes;Exocytosis;feeding;Fellowship;Future;Gene Combinations;Gene Structure;Genes;Goals;high resolution imaging;Hour;Imaging Techniques;Immigrant;Immune Evasion;In Vitro;Infection;Insecta;interest;Intervention;Invaded;Investigation;knock-down;Knock-out;knockout gene;Laboratories;Life Cycle Stages;live cell imaging;Location;Lytic Phase;Maps;Mastigophora;Measures;Mediator;metacyclogenesis;Microscopy;Molecular;molecular marker;monolayer;Morphogenesis;Morphology;mutant;neglected tropical diseases;Nifurtimox;novel;parasite invasion;Parasites;pathogen;Pathogenesis;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase;Play;Population;Populations at Risk;prevent;Process;Proliferating;Proteins;real-time images;Research;Research Personnel;Resolution;Resources;Risk;Role;Rupture;Sampling;Serum;side effect;single-cell RNA sequencing;South America;Stream;Structure;success;System;Testing;therapeutic development;Time;tool;transcriptome;transcriptomics;transmission blocking;transmission process;Trypanosoma cruzi;ultra high resolution;Universities;Vaccines;Validation;Virulence;Visualization;Work

PROJECT_TITLE: Defining the molecular mediators of cell morphogenesis in Trypanosoma cruzi


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Mental Health;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative:  The long-term goal of this research program is to better understand the racial inequities in current infant feeding practices. This research will lay the groundwork needed for policy change and tailored clinical interventions aimed at addressing these inequities in infant feeding practices.

PI_NAMEs: SLATER, COURTNEY N. (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Academy;Address;Affect;Age;Age Months;American;Award;Birth;Black race;black women;Breast Feeding;career;Child Care;Chronic Disease;Clinical;clinical practice;Competence;County;Data Analyses;Data Collection;Death Rate;disorder risk;Employment;Ensure;Environment;Equation;Ethics;Exclusive Breastfeeding;Exhibits;experience;feeding;Fellowship;Food;Food Access;food insecurity;Foundational Skills;Funding;General Population;Glean;Goals;Growth;Health;Health Benefit;Health care facility;Health Disparities Research;health disparity;health equity;Health Status;Housing;housing instability;Individual;Individual National Research Service Award;Inequity;Infant;infant morbidity;infant morbidity/mortality;innovation;Intervention;Interview;Investigation;Knowledge;Lactation;Life;Literature;Longitudinal cohort study;longitudinal dataset;low socioeconomic status;marginalization;Maternal Health;Mediating;meetings;Mental Depression;Mental Health;Methods;microbiome research;Modeling;Mothers;National Research Service Awards;Neighborhoods;Nursing Research;Outcome;Pediatrics;perceived stress;Philadelphia;Policies;Population;pre-doctoral;pregnant;programs;prospective;Qualitative Research;racial disparity;Recommendation;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;Risk Factors;Role;Sampling;skill acquisition;social disparities;social health determinants;Socioeconomic Status;Solid;Strategic Planning;Structure;theories;Training;training opportunity;Translations;United States;United States National Institutes of Health;virtual;Woman;Women's study;Work

PROJECT_TITLE: Examining the Impact of Adverse Social Determinants of Health on Infant Feeding Practices among Black Women

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (89)]


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Many lines of evidence suggest that disrupted glutamatergic synaptic function in the cerebral cortex can be an important component of symptom development in schizophrenia (SZ). Other studies, include those from the Anderson lab, have also suggested that mitochondrial weakness may in some instances also contribute to the development of this complex disorder. In this collaborative proposal, we will use novel experimental paradigms involving the study of synaptic energetics using IPSC derived neurons with the goal of demonstrating that synaptic energetics could be an important influencer of, and therapeutic target for, synaptic weakness contributing to the symptoms of schizophrenia.

PI_NAMEs: ANDERSON, STEWART A (contact);COULTER, DOUGLAS A

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 22q;22q11.2;Address;Adult;Affect;Agonist;Bezafibrate;Biogenesis;Birth;Brain Diseases;Brain region;Cerebral cortex;Complex;Dependence;Development;dietary supplements;DiGeorge Syndrome;Disease;Environment;Environmental Risk Factor;excitatory neuron;Exercise;FDA approved;Genes;Genetic;genetic risk factor;Glutamates;Goals;Health;Human;human stem cell-derived;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Link;lymphoblastoid cell line;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial dysfunction;Neurodevelopmental Disorder;Neuronal Dysfunction;Neurons;neuropathology;Neurophysiology - biologic function;neuropsychiatric disorder;novel;Oxidative Phosphorylation;Penetrance;Pharmaceutical Preparations;Ploidies;Presynaptic Terminals;prevent;Prevention approach;Process;Production;Publishing;receptor;Schizophrenia;schizophrenia risk;stem cells;success;Symptoms;Synapses;synaptic function;Synaptic Vesicles;System;Therapeutic;therapeutic target;Transcript

PROJECT_TITLE: Linking mitochondrial and synaptic weakness to schizophrenia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Biocompatibility testing of the COSMIIC System The aim of this supplement is to conduct biocompatibility testing of the COSMIIC System components and to make the testing procedures and results available to the public under our open source licenses.

PI_NAMEs: CHESTEK, CYNTHIA ANNE;KILGORE, KEVIN L. (contact);SMITH, BRIAN

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: Biological;biomaterial compatibility;Chemicals;Devices;Evaluation Reports;Feasibility Studies;insight;Licensing;open source;Procedures;Publishing;Risk Assessment;System;Test Result;Testing;Toxicology


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Health Effects of Indoor Air Pollution;Infectious Diseases;Microbiome

ORG_CITY: VERMILLION

ORG_NAME: UNIVERSITY OF SOUTH DAKOTA

ORG_STATE: SD

PHR: STATEMENT OF PUBLIC HEALTH SIGNIFICANCE Salmonella enterica serovar Typhimurium is a NIAID category B priority pathogen and a leading cause of morbidity and mortality from enteric disease globally. Colonization of cockroaches by S. Typhimurium not only provides an environmental reservoir and vector-borne transmission route for the pathogen but also creates a unique interphase for the evolution of variants with concerning properties such as antimicrobial resistance. An improved understanding of how passage of S. Typhimurium through cockroach vectors influences pathogen genotype and phenotype will provide novel, naturally relevant insight into pathogen evolution and may suggest insect control as a simple intervention to mitigate evolution of enteric pathogens.

PI_NAMEs: PIETRI, JOSE ENRIQUE (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Affect;Animals;Anti-microbial susceptibility;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;Category B pathogen;clinically relevant;commensal bacteria;Competence;Data;Dictyoptera;Disease;DNA;Enteral;enteric pathogen;Environment;Evolution;Excretory function;Feces;fitness;Gastrointestinal tract structure;Genes;genome sequencing;Genotype;German population;gut microbes;gut microbiota;Homologous Gene;Horizontal Gene Transfer;Hour;Human;improved;Infection;Ingestion;Insect Control;Insecta;insight;Interphase;Intervention;Laboratories;Mechanics;microbiota;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;Nature;novel;pathogen;pathogenic bacteria;Pattern;Phenotype;Plasmids;Population;pressure;Process;Proliferating;Property;Public Health;Resistance;Resistance profile;Route;Salmonella;Salmonella typhimurium;Serial Passage;Surface;Testing;transmission process;Variant;vector;vector-borne;whole genome

PROJECT_TITLE: Evolution of Salmonella in a cockroach vector

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-C (02)]


ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: PROJECT NARRATIVE CpG-B oligonucleotides are short, unmethylated DNA sequences that can mimic bacterial DNA and are powerful immunomodulators that can be used in a wide range of inflammatory and autoimmune diseases. This proposed project aims to elucidate two distinct, CpG-B ODN mediated, TLR9 dependent mechanisms and whether these molecules are protective in two lupus mouse models.

PI_NAMEs: OAKLAND, DAVID NOAH (contact)

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;Agonist;American;Anti-Inflammatory Agents;Autoimmune Diseases;B-Lymphocytes;Bacterial DNA;Base Sequence;cell type;Cells;chronic autoimmune disease;Clinical;Coculture Techniques;conditional knockout;cytokine;Data;Dendritic Cells;differentiation in vitro;Disease;DNA;DNA Sequence;Doctor of Philosophy;effective therapy;efficacy evaluation;Endosomes;Enzyme-Linked Immunosorbent Assay;Escherichia coli;experimental study;Flow Cytometry;Future;gut microbiome;gut microbiota;Human;Immune system;Immunomodulators;immunomodulatory therapies;immunoregulation;Immunosuppressive Agents;improved;In Vitro;in vivo;Inflammatory;Interleukin-10;Interleukin-6;Knock-out;Knockout Mice;Laboratories;Leukocytes;Link;Lupus;lupus prone mice;lupus-like;Mediating;microbiome;Modeling;Molecular;mouse model;Mus;Myeloid Cells;neutralizing antibody;novel;Oligonucleotides;Pathogenesis;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Physicians;Play;Population;Pristane;Production;Productivity;Proliferating;protective effect;reduce symptoms;renal damage;Research;response;Role;Scientist;sensor;side effect;skills;Splenocyte;symposium;Symptoms;Systemic Lupus Erythematosus;Therapeutic;TLR3 gene;TLR9 gene;Training;Work

PROJECT_TITLE: CpG-B ODN Mediated Protection from Systemic Lupus Erythematosus


ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE Sepsis is a complex, heterogenous disease with significant mortality due to both acute and chronic immune dysregulation. Current therapeutic options for sepsis treatment fail to adequately address both acute hyperinflammation and chronic critical illness in sepsis patients, a gap the Luo Lab will fill with its novel, bioactive itaconate-loaded telodendrimer nanoparticle (ITA:TD NP) for effective dual inhibition of LPS-mediated inflammation and immune cell pyroptosis. The proposed research aims are to investigate ITA:TD NP-mediated inhibition of hyperinflammation in sepsis and elucidate the protective effect of ITA:TD NP to prevent chronic critical illness-associated morbidity and mortality.

PI_NAMEs: MESSINA, JENNIFER M (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Acute;Address;Anti-Inflammatory Agents;Attenuated;Bacterial Infections;Binding;biomaterial compatibility;Cachexia;Catabolism;cecal ligation puncture;Cell Death;Cells;Cessation of life;Charge;Chronic;Clinic;Competitive Binding;Complex;Critical Illness;cytokine;cytokine release syndrome;cytotoxicity;Development;Disease;Dose Limiting;Drug Kinetics;efficacy evaluation;Encapsulated;Endotoxins;extracellular;Extravasation;Fatty Acids;Functional disorder;Gram-Negative Bacterial Infections;gram-negative sepsis;Homeostasis;Human;IL18 gene;Immune;immune activation;Immune response;Immune System Diseases;Immunologic Stimulation;immunomodulatory therapies;immunoregulation;Immunosuppression;improved;improved outcome;in vivo;Infection;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Injections;insight;Interleukin-1 beta;Leukopenia;Lipopolysaccharides;Lymphocyte Function;Lymphopenia;Lytic;Macrophage;Mediating;Membrane;Metabolic;Metabolism;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;mouse model;Multiple Organ Failure;Mus;Myelogenous;nanocarrier;nanodrug;nanoparticle;nanotherapeutic;neutrophil;Nosocomial Infections;novel;Organ;pathogen;Patient Care;Pattern;Phase;prevent;Prevention;Production;Property;protective effect;Pseudomonas aeruginosa infection;recruit;Recurrence;Regulation;Research;response;Risk Reduction;secondary infection;Sepsis;septic;septic patients;Series;Signal Transduction;Solubility;Survivors;Syndrome;synergism;Tail;Therapeutic;Tissues;TLR4 gene;TNF gene;Toxic effect;Toxin;Whole Blood

PROJECT_TITLE: Targeting Both Hyperinflammation and Pyroptosis Via Nanotherapeutics to Improve Outcomes in Gram-Negative Sepsis


NIH_SPENDING_CATS: Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Infectious Diseases

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Helicobacter pylori is a globally prevalent pathogen that contributes to the burden of disease by maintaining life-long chronic infections that lead to severe gastrointestinal diseases and gastric cancers. Currently recommended therapies are approximately 75-80% effective, which has led both the World Health Organization and the NIH to categorize H. pylori as a high research priority pathogen. This proposal aims to elucidate growth mechanisms that facilitate disease causing H. pylori infections by characterizing the role of RsfS and ribosome silencing in chronic H. pylori infections.

PI_NAMEs: ELSHENAWI, YASMINE  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Affect;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Biological Assay;Biopsy;burden of illness;Categories;Chronic;chronic infection;Clinical Trials;collaborative approach;Data;Development;differential expression;Disease;effective therapy;Elements;Epithelium;Escherichia coli;Exposure to;Gastric Adenocarcinoma;Gastric Glands;Gastric mucosa;gastrointestinal;Gastrointestinal Diseases;Genes;Gland;Goals;Growth;Helicobacter Infections;Helicobacter pylori;Homologous Gene;Immune Evasion;Immune system;In Vitro;in vivo;Infection;innovation;insight;Investigation;Knock-out;Knowledge;Liquid substance;Lymphoma;malignant stomach neoplasm;Microbial Biofilms;Modeling;Mus;mutant;novel;Outcome Study;Outcomes Research;pathogen;pathogenic bacteria;Patients;Phase;Physiological;Population;Positioning Attribute;prevent;priority pathogen;promoter;Promoter Regions;protein expression;Protocols documentation;Publishing;Recommendation;Recording of previous events;Regulation;Research;Research Priority;Ribosomal Proteins;ribosome profiling;Ribosomes;Role;Scientist;Serum;Specialist;Stomach;Stress;Techniques;Testing;Therapeutic;therapeutically effective;Training;Transcript;United States National Institutes of Health;Up-Regulation;Work;World Health Organization

PROJECT_TITLE: How ribosomal silencing promotes chronic infection of the gastric pathogen Helicobacter pylori


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE The number of people who live with dementia, the impaired ability to remember, think, or make everyday decisions that interferes with daily activities, is increasing rapidly with some estimating a tripling of the number by 2050. With this increase in cases, existing disparities in who develops the disease will also continue to widen, with those living in poverty becoming more likely than they already are to develop dementia. This project will look at how where one lives might impact their risk for developing dementia, by considering the resources and opportunities that are available to them because of the neighborhoods they live in.

PI_NAMEs: KRISHNAMURTHY, SUDARSHAN  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Adult;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid;Apolipoprotein E;Area;blood lipid;Blood Pressure;Brain;brain health;Brain imaging;brain volume;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cerebrovascular Circulation;clinical center;Clinical Data;clinical examination;Clinical Protocols;Cognition;Cognitive;cognitive change;cognitive function;cohort;Communication;Data;Data Analyses;Degree program;Dementia;dementia risk;density;deprivation;design;Dimensions;Disease;Disparity;Doctor of Medicine;Doctor of Philosophy;Education;Employment;Enrollment;Environment;Environmental Health;Evaluation;experience;Faculty;Feedback;Fellowship;Future;Genotype;Glycosylated hemoglobin A;Grant;Health;Health Disparities Research;Heart Rate;High Density Lipoproteins;Hip region structure;Hippocampus;Housing;imaging biomarker;Impaired cognition;Impairment;indexing;Individual;insight;Internal Medicine;Knowledge;Learning;Linear Regressions;Literature;Manuscripts;Measures;Mediating;Mediation;Medical;medical schools;member;mental state;Mentorship;Metabolic;Methodology;mild cognitive impairment;Molecular Medicine;multidisciplinary;National Research Service Awards;neighborhood disadvantage;Neighborhoods;neurocognitive test;Neurofibrillary Tangles;neuroimaging;Neurology;neuropathology;novel;OGTT;older adult;Pathology;Persons;Phenotype;Play;Population;Population Heterogeneity;Positioning Attribute;Positron-Emission Tomography;Poverty;pre-clinical;Preparation;Prevalence;programs;Pulse Pressure;Qualifying;Quality of life;Regression Analysis;Research;resilience;Resources;Risk;Risk Factors;Senile Plaques;Series;social health determinants;social influence;socioeconomic disadvantage;Structure;Thick;Thinness;Training;Translational Research;Universities;White Matter Hyperintensity;Work;Writing

PROJECT_TITLE: Investigating Impacts of Neighborhood Disadvantage on ADRD risks, imaging biomarkers, and cognition

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The research described in this proposal will investigate the role of calorie restriction (CR)-induced blood factors in rejuvenating the aged brain. The proposed study will delineate cellular and molecular mechanisms underlying the rejuvenating effects of CR blood plasma on learning and memory processes in the aged hippocampus and identify individual circulating blood factors as potential therapeutic targets. The results of this study will significantly increase the translational potential of leveraging the benefits of CR to reverse cognitive impairments in the elderly unable to adhere to CR interventions - both in the context of brain aging and age-related neurodegenerative disease such as Alzheimer’s disease.

PI_NAMEs: MISRA, RHEA  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Adherence;age related;age related decline;age related neurodegeneration;Age-associated memory impairment;Aging;aging brain;aging hippocampus;aging population;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;animal old age;arm;Behavioral;Blood;Brain;Brain region;Caloric Restriction;Calories;Chronic;Cognition;Cognitive;Cognitive aging;cognitive benefits;Cognitive deficits;cognitive function;cognitive performance;conditioned fear;Confocal Microscopy;Data;Dendritic Spines;density;Diet and Nutrition;Dietary Intervention;dietary restriction;Drug Metabolic Detoxication;Elderly;Enzymes;Exercise;Exhibits;extend lifespan;feeding;Goals;GPX3 gene;healthspan;Hippocampus;Human;Hydrogen Peroxide;Immunohistochemistry;Impaired cognition;improved;Individual;Induced Neurons;Intake;Intervention;juvenile animal;Learning;Life;Link;Literature;Longevity;Malnutrition;Mass Spectrum Analysis;Mediating;Memory;memory process;Methods;Modeling;Modification;Molecular;mouse model;Mus;Neurodegenerative Disorders;Neuronal Plasticity;Neurons;non-genetic;nonhuman primate;novel;object recognition;old mice;Organism;Oxidative Stress;Pathology;Pathway interactions;Performance;Plasma;Population;Populations at Risk;prevent;Proteomics;Radial;Rejuvenation;Research;Risk;Risk Factors;Role;Severities;single nucleus RNA-sequencing;SIRT1 gene;spatial memory;Synapses;Synaptic plasticity;systemic intervention;Testing;theories;Therapeutic;therapeutic target;translational applications;translational potential;Viral;water maze;Work;Yeasts

PROJECT_TITLE: Investigating the role of calorie restriction-induced blood factors in rejuvenating the aged hippocampus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Hypertension;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: COLLEGE STATION

ORG_DEPT: PSYCHIATRY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Post-traumatic stress disorder (PTSD) is a debilitating psychiatric disorder that significantly increases the risk for the development of inflammatory conditions and cardiovascular disease such as hypertension, but the causes of these increased risks remain unknown. We have recently identified that the autonomic system, via the splenic nerve, is causal in linking psychological trauma, T- lymphocyte inflammation, and hypertension sensitization in a preclinical murine model of PTSD. In this proposal, we will mechanistically investigate how the autonomic system contributes to T- lymphocyte inflammation and downstream hypertension after psychological trauma, which may new therapeutic targets and/or predictive biomarker for inflammatory and cardiovascular diseases in the PTSD population.

PI_NAMEs: LAUTEN, TATLOCK H (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Ablation;Achievement;Affect;American;Angiotensin II;Animals;Area;arm;Attenuated;Automobile Driving;Autonomic Dysfunction;Autonomic nervous system;Autonomic Pathways;Behavior;Behavioral;beta-adrenergic receptor;Blood Pressure;Brain;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Catecholamines;Cells;Cessation of life;Clinical Management;comorbidity;cytokine;Denervation;designer receptors exclusively activated by designer drugs;Development;Disease;Etiology;Exhibits;Exposure to;Future;Genetic;genetic technology;Goals;Hypertension;hypertension control;hypertensive;Immune;immune function;Immune system;Inflammation;Inflammatory;Institution;Interleukin-6;Interleukins;Knock-out;Learning;life span;Link;lymphoid organ;Mediating;Mental disorders;Mental Health;Modeling;mouse model;Mus;Nerve;neural;new therapeutic target;Norepinephrine;Operative Surgical Procedures;Organ;Output;Pathogenesis;Pathology;Pathway interactions;Patients;Peptides;Peripheral;Persons;Physiological;Physiology;Population;Post-Traumatic Stress Disorders;pre-clinical;predictive marker;Predisposition;psychological trauma;Receptor Signaling;Regulation;Reporting;Research Personnel;response;Risk;Role;Signal Pathway;Signal Transduction;social defeat;Source;Spleen;Stress;System;systemic inflammatory response;T-Cell Development;T-Lymphocyte;targeted biomarker;Techniques;Technology;Testing;Training;Transferable Skills;Trauma;Tyrosine 3-Monooxygenase;Work

PROJECT_TITLE: Deciphering the autonomic regulation of inflammation and hypertension sensitization after psychological trauma


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE Aberrant neuronal cell death during brain development or throughout lifespan can lead to neurodevelopmental or neurodegenerative diseases. Knowledge about precise control of neuronal survival is essential to dissecting the underlying pathogenic mechanisms. Our proposed studies will provide novel insights to how neuronal survival is mediated by alternative mRNA splicing and to the etiology of neurological disorders.

PI_NAMEs: ZHENG, SIKA  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Affect;Alleles;Alternative Splicing;Alzheimer's Disease;Apoptosis;Apoptotic;BAK1 gene;Binding Proteins;Biochemical;Biochemistry;Brain;Brain region;brain tissue;CASP2 gene;Cell Death;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combat;Competence;Comprehension;Computational Biology;conditional knockout;Coupled;CRISPR interference;Cues;Data;Death Rate;Development;Elements;environmental adaptation;Equilibrium;Etiology;Evaluation;Exhibits;Exons;Gene Expression;Generations;Genes;Genetic;Genetic Complementation Test;genetic manipulation;Genetic Transcription;Germ Lines;Growth Factor;Health;Homeostasis;Impairment;In Vitro;in vivo;innovation;insight;internal control;Investigation;Knowledge;Learning;Life;life span;Light;Maps;Mediating;Memory;Messenger RNA;Methodology;Methods;Molecular;mRNA Decay;mRNA Precursor;Mus;Neonatal;Nervous System Disorder;neural;neural circuit;Neurobiology;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuron apoptosis;neuron development;neuron loss;Neuronal Differentiation;neuronal survival;Neurons;neuroregulation;Nonsense Codon;novel;novel strategies;Organism;paralogous gene;Pathogenicity;Polypyrimidine Tract-Binding Protein;Positioning Attribute;postnatal;posttranscriptional;Predisposition;prevent;Productivity;protein expression;Protein Isoforms;Proteins;Proteomics;Recording of previous events;Regulation;Regulatory Element;Reporter;Research;resilience;Resistance;RNA;RNA Splicing;RNA-Binding Proteins;Role;screening;Shapes;Stimulus;Testing;tool;Transcript;transcriptomics;Translations;Untranslated RNA

PROJECT_TITLE: Genetic control mechanisms of long-term neuronal survival

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]