NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Mental Health;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: Narrative Understanding how memories change over time in the brain is central to the science of memory distortion. This proposal examines how shifting interactions between hippocampal and cortical memory systems give rise to distortions in memory, using computational modeling to make predictions that are tested with functional neuroimaging (fMRI) and non-invasive brain stimulation techniques (TMS). Detailing the interplay of hippocampal and cortical memory systems will provide nuance to current research in memory consolidation, which may lead to improved methods for testing the nature of memory distortions in patients with diffuse cortical damage and potentially provide improved rehabilitation strategies.

PI_NAMEs: TOMPARY, ALEXA  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Address;Animals;Anterior;Award;Behavior;Behavior Control;Behavioral;Brain;Categories;Clinical;Cognitive;Computer Models;Conceptions;diagnostic tool;Diffuse;Episodic memory;Event;experience;experimental study;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Hippocampus;Image;Impairment;improved;individual variation;innovation;insight;Knowledge;knowledge integration;Lead;Learning;Link;Location;Measures;Memory;memory consolidation;Memory impairment;Mentorship;Methods;Modeling;National Institute of Neurological Disorders and Stroke;Nature;neural;neural network;Neural Network Simulation;neuroimaging;noninvasive brain stimulation;novel;novel strategies;Outcome;Participant;Pathology;Patients;predictive modeling;predictive test;Protocols documentation;reconstruction;rehabilitation strategy;Research;Research Personnel;Rest;Retrieval;Role;Scanning;Science;semantic processing;Semantics;Shapes;Signal Transduction;Source;spatial memory;stroke patient;System;Techniques;Temporal Lobe;Test Result;Testing;theories;therapy development;Time;Training;Transcranial magnetic stimulation;Variant;Work

PROJECT_TITLE: Disentangling hippocampal and cortical contributions to episodic memory

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Fetal Tissue;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Narrative The human skeleton and its major joints, such as the hip and knee, arise developmentally as result of coordinated programs governing cartilage, connective tissue, and bone formation. The proposed research focuses on the role of individual cells in these complex developmental processes in the human hind limb, through the use of state-of-the-art technologies that will define the specific genetic processes cells utilize to give rise to functionally and morphologically distinct tissues and structures. Obtaining this molecular information is both timely and crucial to bridge the gaps in our knowledge of these important skeletal structures, and as such, a new resource will be made available to the scientific and medical communities to promote innovative solutions to orthopedic problems.

PI_NAMEs: CAPELLINI, TERENCE D (contact);CRAFT, APRIL MARIE

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;acetabulum;Aging;Anatomy;Architecture;Articular ligaments;ATAC-seq;Behavior;Biological;Biological Assay;Biology;Bone structure;Cartilage;cartilage cell;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cell Separation;Cells;Cellular biology;Chondrocytes;Chromatin;Cleavage Under Targets and Release Using Nuclease;Communities;Complex;Connective Tissue;Data Set;Development;developmental disease;Developmental Process;Disease;Distal;Elements;Ensure;Epigenetic Process;Epiphysial cartilage;Event;Extracellular Matrix;Femur;femur head;Fibroblasts;functional genomics;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Processes;Genetic Transcription;Genomic Segment;Genomics;Grant;Growth;Hip Joint;Hip region structure;Histologic;Human;ilium;Immunohistochemistry;In Situ Hybridization;in utero;In Vitro;in vivo;Individual;innovation;insight;Investigation;ischium;Joint Capsule;Joints;Knee;Knee joint;Knowledge;Ligaments;Limb structure;Link;Location;Locomotion;Mediating;Medical;Meniscus structure of joint;Methods;Molecular;Molecular Profiling;Morphology;Multiomic Data;multiple omics;Musculoskeletal;novel;Nucleic Acid Regulatory Sequences;Orthopedics;Osteogenesis;Pattern;Pelvis;Pharmacologic Substance;Phenotype;Population;population based;Process;programs;Property;Protocols documentation;Regenerative Medicine;regenerative therapy;Regulatory Element;Reporter;Research;Research Personnel;Resolution;Resources;Role;Sampling;Shapes;single cell ATAC-seq;skeletal;skeletal disorder;skeletal maturation;Skeleton;soft tissue;spatial relationship;Specimen;Structure;Synovial Membrane;Technology;Therapeutic;tibia;Tissue-Specific Gene Expression;Tissues;tool;transcription factor;transcriptome sequencing;transcriptomics;Weight-Bearing state

PROJECT_TITLE: Molecular architecture of the human knee joint and pelvis at single cell resolution

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Aging results in a severe decline of skeletal muscle regenerative potential and a diminished response to aerobic exercise, which manifests clinically as impaired muscle function, increased risk of adverse events, and loss of independence. The proposed study will advance our mechanistic understanding of how dysregulation of the hypoxia signaling pathway in aging impacts muscle regeneration and aerobic exercise adaptation. Importantly, it will further evaluate whether restoration of hypoxia signaling improves muscle function in a murine model of aging.

PI_NAMEs: SINHA, INDRANIL  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Activities of Daily Living;Adverse event;adverse event risk;adverse outcome;Aerobic Exercise;Affect;Aging;aging related;angiogenesis;ARNT gene;Biological;Blood capillaries;Cell Nucleus;Cell Survival;Clinical;Cytoplasm;Data;density;Down-Regulation;Elderly;Enzymes;Exercise;Exhibits;experimental study;FDA approved;Fiber;frailty;functional decline;Gene Expression;Gene Modified;Genes;Genetic Transcription;Goals;Hindlimb;Human;Hypoxia;Hypoxia Inducible Factor;Hypoxia Pathway;Impairment;improved;inhibitor;innovation;interest;Intervention;Laboratories;Maintenance;Mediating;Metabolic Pathway;mortality risk;mouse model;multicatalytic endopeptidase complex;Mus;Muscle;muscle form;Muscle function;muscle progenitor cell;muscle regeneration;Muscular Atrophy;Myopathy;notch protein;novel;novel therapeutics;old mice;older patient;overexpression;Pathway interactions;Peroxisome Proliferator-Activated Receptors;pharmacologic;Phenotype;Physiological;Population;Procollagen-Proline Dioxygenase;Proteins;regeneration potential;Regenerative capacity;response;Response Elements;restoration;Role;sarcopenia;Signal Pathway;Signal Transduction;skeletal;Skeletal Muscle;skeletal muscle wasting;skeletal preservation;Testing;Therapeutic;transcription factor;transcriptome;translational potential;treatment strategy;Up-Regulation

PROJECT_TITLE: PHD2 mediated loss of hypoxia signaling limits skeletal muscle regeneration and exercise response in aging

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: HOUSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: Project Narrative Skeletal muscle wasting is a major reason for frailty and loss of independence in various disease states, including cancer and in the elderly population. However, cellular and molecular mechanisms of skeletal muscle wasting in remain poorly understood. Our proposed studies will identify novel molecular mechanisms that may lead to the development of novel therapeutic approaches for the prevention of muscle loss in cancer patients and during aging.

PI_NAMEs: KUMAR, ASHOK  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Ablation;Acceleration;activating transcription factor 1;Adult;Advanced Malignant Neoplasm;Aging;Antibodies;ApcMin/+ mice;Apoptosis Promoter;arm;ATF6 gene;Atrophic;Attenuated;Binding;Cachexia;Cancer Cachexia;Cancer Model;Cancer Patient;cell injury;Cell Surface Receptors;Chronic;Chronic Disease;Complication;cytokine;Denervation;Development;Disease;Elderly;Endoplasmic Reticulum;endoplasmic reticulum stress;Eukaryotic Initiation Factors;Exercise;experimental study;frailty;Gene Expression;Genetic;Homeostasis;improved;In Vitro;in vivo;Individual;Induction of Apoptosis;Inflammation;Inflammatory;Inositol;knock-down;Knockout Mice;KRASG12D;Link;Malignant Neoplasms;Mediating;Mediator;member;Membrane;Metabolic;Metabolic dysfunction;Mitochondria;Modeling;Molecular;mouse model;Mus;Muscle;Muscle Fibers;muscle form;Muscle function;Muscular Atrophy;Neuromuscular Junction;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Nutrient;old mice;Organelles;overexpression;Oxidative Stress;pancreatic cancer model;Pathway interactions;Patients;Phosphotransferases;Population;pre-clinical;prevent;Prevention;Prevention approach;PRKR gene;Prokaryotic Initiation Factor-2;Protein Biosynthesis;protein degradation;protein folding;Protein Secretion;Proteins;receptor;Regulation;Reporting;Repression;response;RNA Splicing;Role;sarcopenia;sensor;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle differentiation;skeletal muscle growth;Skeletal Muscle Neoplasm;skeletal muscle wasting;Stress;Syndrome;System;Therapeutic;tissue degeneration;TNF gene;tumor;XBP1 gene

PROJECT_TITLE: TWEAK/Fn14/UPR Signaling in Skeletal Muscle Wasting


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Chronic Pain;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: DENTISTRY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Cancer invading to the nerve, a process termed perineural invasion (PNI), makes cancer more difficult to eradicate and causes significant pain. This proposal explores the potential role of Schwann cells, a group of cells that surround and support nerve axons and become activated in response to insults to the nerves in oral cancer PNI and pain. A better understanding of Schwann cells in cancer PNI and pain will help develop novel strategies for PNI and pain control in oral cancer.

PI_NAMEs: YE, YI  (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Address;Afferent Neurons;Animal Behavior;Animal Model;Axon;axon injury;Behavior;cancer cell;Cancer Cell Growth;cancer invasiveness;cancer pain;Cancer Patient;carcinogenesis;Cell Culture Techniques;cell type;Cells;Cellular biology;Clinical Trials;Coculture Techniques;Colon Carcinoma;comorbidity;cytokine;Data;Disease Progression;Electrophysiology (science);Etiology;Functional disorder;Gene Deletion;Goals;Grant;Growth;Human;Hypersensitivity;Immune System Diseases;Impairment;improved;in vivo;Induced Neurons;inhibitor;intense pain;Interruption;Invaded;Knowledge;Link;malignant mouth neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Mechanics;Mediating;Mediator;migration;Modeling;Mus;Myelin;myelination;Nerve;Nerve Degeneration;nerve injury;Nerve Regeneration;Nervous System Disorder;Neuroglia;Neurons;Nociception;Nociceptors;novel strategies;novel therapeutics;Oncology;Opioid;Oral;oral pain;overexpression;Pain;Pain Clinics;Pain management;painful neuropathy;Pathology;Patients;perineural;Peripheral;Peripheral Nerves;Process;Prognosis;Proliferating;Quality of life;receptor;receptor expression;Recombinants;repaired;Reporting;Research;response;response to injury;Role;Schwann Cells;Severities;side effect;statistics;Testing;therapeutic evaluation;Tissues;TNF gene;Tropism;tumor;Tumor Necrosis Factor Receptor;tumor progression

PROJECT_TITLE: Schwann cell activation in oral cancer perineurial invasion and neuropathic pain

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Patient Safety;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Obesity in childhood is highly prevalent and associated with increased risk of certain cancers, cardiovascular disease, diabetes, and reduced quality of life. Despite much national attention and research, obesity prevalence continues to rise, and substantial disparities persist, suggesting a large gap between research and practice. This proposal will evaluate the dissemination and implementation of an effective intervention using electronic health records to improve the management of overweight and obesity in pediatric primary care within different practice settings serving low-income, minority, and rural children disproportionately impacted by obesity to reduce obesity prevalence and disparities.

PI_NAMEs: SHARIFI, MAHNOOSH  (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: 12 year old;Address;Adolescent;Adoption;Adult;Affect;Attention;Award;behavior change;Body mass index;Cardiometabolic Disease;Cardiovascular Diseases;care delivery;Child;Childhood;clinical care;clinical decision support;Clinical Informatics;Clinical Trials;Collection;Consolidated Framework for Implementation Research;contextual factors;Data;data de-identification;data warehouse;demographics;Diabetes Mellitus;Diagnosis;Disparity;Disparity population;disparity reduction;Dissemination and Implementation;Educational Materials;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;effectiveness/implementation study;Electronic Health Record;ethnic minority;Ethnic Origin;Evaluation;evidence base;evidence based guidelines;experience;formative assessment;future implementation;Geography;Group Practice;Health;Health system;high risk;Human;Hybrids;implementation efforts;implementation evaluation;implementation facilitation;implementation facilitators;implementation intervention;implementation outcomes;implementation science;implementation strategy;implementation tool;improved;Indiana;Intervention;Low income;Maintenance;Malignant Neoplasms;Massachusetts;Mediating;Methods;Minority;minority children;Modeling;models and simulation;mortality;Obesity;Obesity associated cancer;obesity in children;obesity management;obesity risk;organizational readiness;Outcome;Overweight;Parents;patient population;Patients;Pediatric Hospitals;pediatrician;Philadelphia;Population;practice setting;practice-based research network;Prevalence;prevent;Primary Care;primary care clinician;primary care practice;primary care setting;Process;Provider;Psychology;Public Health;Qualitative Methods;Quality of Care;Quality of life;Race;racial minority;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Research;Research Design;Resources;Risk;Rural;Sampling;Site;social;socioeconomics;theories;tool;trial design;United States;United States Preventative Services Task Force;Universities;uptake;urban disparity;user centered design;Well in self;Work;Youth

PROJECT_TITLE: Implementation of Decision Support for the Management of Obesity in a National Pediatric Primary Care Research Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(56)]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetic Testing;Genetics;Health Services;Human Genome

ORG_CITY: MINNEAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE As the genetic counseling field has grown to over 4,000 and the profession has integrated across healthcare specialties, there is greater need for genetic counselors to be able to research the practice in an evidence-based fashion. Genetic counselors are primed to study the profession in their current roles, but additional research training is needed to foster necessary skills and methodology expertise to lead independent research programs in academia, clinic, industry, public and population health settings. To support this advancement of the field, we propose the first ever, two-year, part-time research fellowship for four genetic counselors called the Genetic Counseling Fellowship in Research Training (GC-FIRST) with the overarching aim to train genetic counseling research leaders and future mentors.

PI_NAMEs: ZIERHUT, HEATHER  (contact)

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Academia;Applications Grants;career;Clinic;Clinical;clinical implementation;cohort;collaborative approach;Competence;Development Plans;education research;Effectiveness;Environment;evidence base;experience;Feedback;Fellowship;Fellowship Program;formative assessment;Fostering;Foundations;Funding;Future;Genetic Counseling;genetic counselor;genetic technology;genetic testing;Goals;Grant;Healthcare;improved;Individual;Industry;Interdisciplinary Study;Lead;life-long learning;Manuscripts;Master of Science;medical specialties;Mentors;Mentorship;Methodology;Minnesota;Monitor;next generation;Occupations;Outcome;Outcome and Process Assessment;Participant;population health;Positioning Attribute;Program Development;programs;Public Health;Recording of previous events;Research;Research Ethics;research in practice;Research Methodology;Research Personnel;Research Project Grants;research to practice;Research Training;Resources;Role;Series;Services;skills;Students;systematic review;Time;Training;Training Activity;undergraduate student;Universities;Work;Writing


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: BALTIMORE

ORG_DEPT: ORTHOPEDICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Disorders affecting the musculoskeletal system pose a major challenge to US health, due to their frequency, morbidity and resulting disability. The delivery of improved care for patients with musculoskeletal disorders will require more rapid translation of basic knowledge into approaches that improve clinical practice. The training program described in this application is intended to provide the skill set necessary for producing orthopaedic scientists who will be better able to translate new findings from the laboratory to the bedside.

PI_NAMEs: JONES, LYNNE C. (contact);SHAFIQ, BABAR

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Orthopedics;Science;Training

PROJECT_TITLE: Training in Orthopaedic Team Science


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Genetics;Mental Health;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Pediatric mild traumatic brain injury (mTBI) is a major public health problem in the United States. This study permits a pre-injury and post-injury assessment of biopsychosocial predictors and mechanisms of the behavioral, psychiatric, and neurocognitive impact of mTBI, minimizing error and bias that may occur with post- injury retrospective reports of pre-injury status. This study will foster more accurate prediction, earlier identification and improved treatment of children with behavioral, psychiatric, and neurocognitive complications related to mTBI.

PI_NAMEs: MAX, JEFFREY EDWIN (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: 10 year old;Accidents;Adolescent;Age;Behavior Disorders;behavior measurement;Behavioral;Behavioral Mechanisms;biopsychosocial;Birth;Brain;Candidate Disease Gene;Child;Childhood;Childhood Injury;Cognition Disorders;cognitive development;cognitive function;cohort;Data;Development;diagnostic development;Diffuse Axonal Injury;Early identification;Enrollment;Event;Exposure to;Family;Fostering;Fracture;Functional Magnetic Resonance Imaging;Gene Structure;Genetic;Image;improved;Individual;Injury;insight;Investigation;Lesion;Life;longitudinal, prospective study;Measures;Mediating;Mediation;Mental disorders;Methodology;mild traumatic brain injury;neurobehavioral;Neurocognitive;neuroimaging;novel;Orthopedics;Outcome;Pattern;phenomenological models;Phenotype;Predictive Factor;Predisposing Factor;prospective;psychological trauma;Public Health;Recording of previous events;Reporting;Research Design;Risk Factors;Severities;sex;Site;Socioeconomic Status;stressor;Structure;Systems Biology;therapeutic development;Time;Trauma;United States

PROJECT_TITLE: Pediatric Mild Traumatic Brain Injury and the ABCD Study: A Prospective Behavioral, Psychiatric, Neurocognitive, Imaging, and Genetic Investigation


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Patient Safety;Precision Medicine;Prevention;Radiation Oncology

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Patients treated with radiation therapy for metastatic disease of the spine suffer high risk for pathologic spinal fractures (PVF) an integral part of spinal adverse events (SAE). In this work we will determine whether a prediction model, based on our computed tomography derived assessment of structural analysis protocol (CT- SAP) and the measurement of blood turnover markers, demonstrates significantly higher performance in predicting the risk of PVF compared to current clinical protocols in this patient cohort. This study will provide novel data for establishing quantitative assessment of PVF risk in patients with spinal metastasis, thus addressing a critical gap in the ability to evaluate and treat these patients.

PI_NAMEs: ALKALAY, RON N (contact);BALBONI, TRACY A.;HACKNEY, DAVID B.

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adverse event;Aftercare;Blood;bone loss;Bone Resorption;Bone structure;bone turnover;Calcium;Cancer Patient;Clinical;clinical care;clinical practice;clinical predictive model;Clinical Protocols;clinically significant;cohort;Complication;cost;Data;Defect;Development;Disease;Evaluation;Failure;follow-up;fracture risk;Goals;Grant;Guidelines;Health;high risk;Human;Immobilization;improved;Individual;Information Management;Life Expectancy;Lytic;Malignant Neoplasms;Measurement;Measures;Mechanics;Metastatic Neoplasm to the Bone;Methods;Modeling;Morbidity - disease rate;Musculoskeletal Development;Neoplasm Metastasis;neoplastic;neural;Neurologic Deficit;novel;Osteogenesis;Pain;palliate;palliative;Pathologic;Patient risk;Patients;Performance;performance tests;personalized predictions;personalized risk prediction;Population;Positioning Attribute;predictive marker;predictive modeling;Predictive Value;prognostic value;Prospective cohort;Prospective Studies;Protocols documentation;Quality of life;Radiation;radiation effect;Radiation therapy;Risk;Risk Marker;risk prediction;risk prediction model;Risk Reduction;ROC Curve;Sampling;Scanning;Sensitivity and Specificity;Serum;Site;skeletal;Spinal;Spinal Diseases;Spinal Fractures;spine bone structure;Systemic Therapy;Testing;Time;tumor;tumor progression;United States National Institutes of Health;Vertebral Bone;Vertebral column;Work;X-Ray Computed Tomography

PROJECT_TITLE: Predicting Fracture Risk in Patients Treated with Radiotherapy for Spinal Metastatic Disease


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: 8. Project Narrative This project will be one of the most comprehensive evaluations of supermarket food labeling to date, using real-world data from supermarkets, an experiment in a naturalistic online supermarket, and surveys of shoppers who will report on their use of labels while shopping and barriers to purchasing healthy foods and using labels. The study will evaluate the effect of the revised Nutrition Facts Label, mandated for packaged foods by the US Food and Drug Administration by 2021, and updates to the Guiding Stars labeling system, one of the most commonly used dietary quality labeling programs in US supermarkets. Results will inform policymakers, retailers, and manufacturers regarding how best to improve the dietary quality of Americans.

PI_NAMEs: BLOCK, JASON PERRY (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: American;Automobile Driving;Behavioral;Beverages;Calories;Censuses;Chronic Disease;Communication;Consumption;Data;demographics;design;Diabetes Mellitus;Diet;dietary;Eating;Education;effectiveness study;Enrollment;Equity;Ethnic Origin;Evaluation;experience;experimental study;fast food;Fatty acid glycerol esters;Food;Food Labeling;Food Packaging;Grant;Health Food;Healthy Eating;Household;implementation evaluation;improved;Income;Individual;innovation;insight;Interview;Label;Laws;Learning;Link;Low income;Manufacturer;meetings;Methods;Nature;Neighborhoods;new technology;novel;Nutrient;nutrition;Nutrition Labeling;Nutritional;Obesity;Policies;Policy Maker;Product Labeling;programs;Public Health;Quasi-experiment;racial difference;Randomized;randomized trial;Reporting;response;Restaurants;Sales;Scheme;smartphone application;social;social influence;socioeconomic disparity;Structure;sugar;Supermarket;Surveys;System;Technology;Testing;Time;Unhealthy Diet;United States Food and Drug Administration;Update;US State;virtual;Work

PROJECT_TITLE: Label to Table: New Insights into Supermarket Food Labeling

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Public Health Relevance Statement: Glioblastoma multiforme (GBM) and high-grade gliomas are the most common primary malignant brain tumors in adults with a grim prognosis. The current proposal explores an innovative, unique therapeutic approach that targets HDAC-inhibitor mediated reprogrammed tumor cell metabolism. If successful this proposal may set the stage for a novel tumor specific treatment concept that ultimately may allow helping patients suffering from this detrimental disease.

PI_NAMEs: SIEGELIN, MARKUS D (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acute;Adult;aerobic glycolysis;Animals;antitumor effect;Apoptosis;Autophagocytosis;Binding;Biological Models;Brain Neoplasms;c-myc Genes;Carbon Isotopes;Cell Respiration;Cells;Cellular Metabolic Process;ChIP-seq;Clinical;combat;Combined Modality Therapy;Coupled;Dependence;Diagnosis;Digestion;Disease;Disease Progression;Down-Regulation;Energy Metabolism;Enhancers;Enzymes;Epigenetic Process;etomoxir;experimental study;extracellular;fatty acid oxidation;FDA approved;Gene set enrichment analysis;Genes;Genetic;Glioblastoma;Glioma;Glucose;Glycolysis;Goals;HDAC1 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Histones;In Vitro;in vivo;in vivo Model;Induction of Apoptosis;inhibitor;innovation;Life Expectancy;Link;Lipids;Lysosomes;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Mitochondria;Molecular;molecular subtypes;Multiple Myeloma;Mus;neoplastic cell;Nonesterified Fatty Acids;novel;novel therapeutic intervention;oxidation;Oxidative Phosphorylation;Oxygen;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;pre-clinical;Predisposition;Primary Brain Neoplasms;Process;Production;Prognosis;programs;Promoter Regions;public health relevance;Research;resistance mechanism;Role;Signal Transduction;stable isotope;standard of care;stem;temozolomide;Testing;Therapeutic;Therapeutic Intervention;therapy resistant;Time;transcription factor;transcriptome;translational potential;Translations;treatment strategy;tumor;tumor metabolism;United States;Vorinostat;Warburg Effect

PROJECT_TITLE: HDAC Inhibitors Reverse the Warburg Effect and Elicit Metabolic Vulnerabilities in Model Systems of Glioblastoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Bicarbonate transporters control the acid-base balance of the body. Our research indicates that some bicarbonate transporters may in fact transport carbonate, or the sodium carbonate ion pair. Furthermore, some might be capable of conducting the gas carbon dioxide across cell membrane as they transport carbonate. We use a variety of highly sophisticated physiological and computational methods to understand the molecular mechanism by which these transporters function both in normal and disease states.

PI_NAMEs: BORON, WALTER F (contact);TAJKHORSHID, EMAD

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: 3-Dimensional;Acid-Base Equilibrium;Acids;Active Biological Transport;Anions;autism spectrum disorder;base;Bicarbonates;Binding;Binding Sites;Biological Assay;Carbon;Carbon Dioxide;Carbonates;Cell membrane;Cells;Charge;Chemistry;Computing Methodologies;Consumption;Coupled;Coupling;Data;Dental;Diffuse;Diffusion;Disease;Electrophysiology (science);Epilepsy;Equilibrium;Evolution;extracellular;Extracellular Fluid;Family;Family member;Feeling suicidal;Gases;Generations;Genetic Polymorphism;Homeostasis;Human;Hypertension;Illinois;insight;interdisciplinary approach;Interdisciplinary Study;Ions;Kidney;Knockout Mice;Laboratories;Lipids;Liquid substance;Malignant Breast Neoplasm;Maps;mathematical model;Measurement;member;Membrane;Migraine;Modeling;Molecular;Molecular Conformation;molecular dynamics;Monitor;Movement;movement analysis;Mus;Mutation;Nephrons;novel;Nucleotides;Oocytes;Organ;Pathogenesis;Pathway interactions;Perfusion;Physiological;Physiology;Play;preservation;Process;Proximal Renal Tubular Acidosis;Reaction;Regulation;Research;Role;simulation;Single Nucleotide Polymorphism;Site;sodium carbonate;Speed;Structure;Surface;symporter;Techniques;Testing;Thinking;Time;tool;Transport Process;Universities;voltage clamp;Work

PROJECT_TITLE: Molecular mechanism of Na+ -coupled HCO3- transporters:  transport of CO3= and CO2

STUDY_SECTION: KMBD

STUDY_SECTION_NAME: Kidney Molecular Biology and Genitourinary Organ Development[KMBD]


ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative Calcium is the most abundant mineral in the human body and its levels are maintained with the help of the extracellular calcium-sensing receptor (CaSR), a cell membrane protein. Genetic and functional defects in CaSR result in diverse diseases related to calcium metabolism: overactive CaSR leads to low blood calcium level (hypocalcemia) that causes muscle cramping and seizures; whereas underactive CaSR results in high blood calcium level (hypercalcemia), hyperactive parathyroid glands (hyperparathyroidism), kidney stones and various neurological disorders. This work will fill the gap in our structural and mechanistic understanding of CaSR function and regulation that are key to human health, and provide insights into the design of new drugs that will alleviate the CaSR associated medical conditions.

PI_NAMEs: SKINIOTIS, GEORGIOS  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: absorption;Address;Adopted;Affect;autosome;Bartter Disease;Binding;Biochemical;Biological Assay;Biophysics;Blood;Bone Resorption;Calcitonin;Calcium;calcium metabolism;Calcium Signaling;Calcium-Sensing Receptors;Cell membrane;Cell Membrane Proteins;Cell surface;Cells;Chemosensitization;Child;Chronic Kidney Failure;cinacalcet;Clinical;Clinical Treatment;Clinical Trials;Complex;conformational conversion;Coupled;Couples;Coupling;Cryoelectron Microscopy;Cysteine;Defect;design;Development;dimer;Disease;Disease of parathyroid glands;drug action;drug discovery;Drug Modulation;Electrons;Engineering;Environment;experimental study;extracellular;Extracellular Domain;Family;Family member;fluorophore;Future;G-Protein-Coupled Receptors;GABA Receptor;gain of function;Genetic;GTP-Binding Proteins;Health;Heterotrimeric GTP-Binding Proteins;Homeostasis;Human;Human body;Hyperactivity;Hypercalcemia;Hyperparathyroidism;Hypocalcemia;improved;insight;interest;Intestines;Kidney;Kidney Calculi;kidney dysfunction;Lead;Length;Ligand Binding;Ligands;Link;Lipids;loss of function mutation;Maps;Medical;member;Membrane;Metabotropic Glutamate Receptors;Minerals;Molecular Conformation;Monitor;Morbidity - disease rate;mortality;Muscle Cramp;Mutagenesis;Mutation;N-terminal;nanodisk;Neonatal;Nervous System Disorder;new therapeutic target;novel therapeutics;Osteoporosis;Parathyroid gland;Patients;Persons;pharmacologic;positive allosteric modulator;Preparation;protein activation;Proteins;Protomer;PTH gene;rational design;receptor;Receptor Activation;receptor function;Receptor Signaling;recruit;Regulation;Role;Seizures;sensor;Side;side effect;Signal Transduction;single-molecule FRET;Site;Site-Directed Mutagenesis;small molecule;Specificity;Spectrum Analysis;Structure;System;Tail;targeted treatment;Therapeutic;Tissues;Transmembrane Domain;Work

PROJECT_TITLE: Mechanistic Basis of Calcium Sensing Receptor Signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-F(02)M]


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative  The proposed research is relevant to public health because it will advance our understanding of the pathogenesis of pancreatitis, a disease with considerable morbidity and mortality and currently without a treatment. The results will establish the importance of maintaining pancreatic cholesterol metabolism as a clinically relevant modulator of this disease; and identify potential molecular targets amenable for pharmacologic intervention to normalize cholesterol metabolism and reduce pancreatitis severity. Thus, this proposal is relevant to the NIH’s goal to develop research strategies as a basis for disease treatment.

PI_NAMEs: GUKOVSKAYA, ANNA S. (contact)

PROGRAM_OFFICER_NAME: SERRANO, JOSE

PROJECT_TERMS: Acids;Acinar Cell;acute pancreatitis;Applied Genetics;Automobile Driving;Autophagocytosis;Biogenesis;Cell Physiology;Cell Survival;Cells;Cholesterol;Cholesterol Homeostasis;Clinical Research;clinically relevant;Cytoplasmic Organelle;Disease;disease model;Drug Modulation;effective therapy;Exocrine pancreas;Functional disorder;Genetic;Goals;Human;Impairment;Incidence;Inflammation;Inflammatory;Inflammatory Response;Intervention;Lysosomal Storage Diseases;Lysosomes;Measures;Mediating;Mitochondria;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;novel;Organ Model;Oxidative Stress;Pancreas;Pancreatitis;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Play;Pre-Clinical Model;Public Health;Recycling;Regulation;Research;response;Role;Severities;Severity of illness;Simvastatin;Testing;transcription factor;United States National Institutes of Health

PROJECT_TITLE: Dysregulated cholesterol homeostasis, caused by lysosomal/autophagy dysfunction, mediates pancreatitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-Y(04)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetics;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: Epstein-Barr virus (EBV) is responsible for over 200,000 new cancer cases annually. At present, there are no viral-specific therapies to treat EBV-associated disease. This proposal focuses on viral and cellular mechanisms that coordinate metabolism with gene expression, and how this impacts control of viral infection and tumorigenesis. This study will provide new information on metabolic control of viral latency and new opportunities for therapeutic intervention for EBV-associated cancers.

PI_NAMEs: TEMPERA, ITALO  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Adenine;Adenosine;Adenosine Kinase;Anabolism;ATAC-seq;ATRX gene;B Cell Proliferation;B lymphocyte immortalization;B-Lymphocytes;cell transformation;Cells;Cellular biology;ChIP-seq;Chromatin;Chromatin Modeling;Chromosomes;Complex;Data;DAXX gene;Deaminase;DNA Binding;EBV-associated disease;Enzymes;Epigenetic Process;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus Nuclear Antigens;Epstein-Barr Virus-Related Malignant Neoplasm;Event;G-Protein-Coupled Receptors;gammaherpesvirus;Gene Expression;Genes;Genome;helicase;Histone H3.3;Human Herpesvirus 4;Human Herpesvirus 8;Immune;Immune signaling;Inflammatory;inhibitor;Link;Lymphomagenesis;Lytic Virus;Malignant Neoplasms;Mass Spectrum Analysis;Metabolic;Metabolic Control;Metabolism;metabolomics;Molecular Chaperones;mouse model;new therapeutic target;novel;Nuclear;Pathway interactions;Play;Poly-fluoroalkyl substances;Primary Infection;Process;programs;Proteins;purine metabolism;Purines;Purinoceptor;Regulation;Role;selective expression;Signal Transduction;Testing;Therapeutic Intervention;Transcriptional Activation;Transcriptional Regulation;transcriptional reprogramming;transcriptome sequencing;tumor;tumorigenesis;Viral;Viral Genes;Viral Physiology;Virus;Virus Diseases;Virus Latency;virus related cancer

PROJECT_TITLE: Regulation of EBV Latency by Purine Metabolism and Signaling

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Activity;Physical Rehabilitation;Precision Medicine;Rehabilitation;Stroke

ORG_CITY: ATLANTA

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: SPENCER, JACOB  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Acute;Address;Ankle;biomechanical test;Biomechanics;Brain;Central Nervous System;Clinical;clinical training;clinically relevant;cohort;Collection;combat;Community Participation;Data;Data Collection;Decision Making;design;Early treatment;effective intervention;effective therapy;Electric Stimulation;Exhibits;experience;Face;Flexor;follow-up;functional electrical stimulation;functional improvement;functional outcomes;Funding;Future;Gait;Gait abnormality;gait rehabilitation;Gait speed;Goals;group intervention;Hoffman's Reflex;Hour;improved;Individual;individual response;innovation;insight;inter-individual variation;Intervention;Learning;Long-Term Effects;Measurement;Measures;Mentors;model design;Motor;Motor Evoked Potentials;motor learning;Motor Neurons;Muscle;Nervous System;neural correlate;Neurological disability;Neuromechanics;neuromechanism;Neuronal Plasticity;neurophysiology;neuroregulation;novel;Parents;Paresis;Participant;Pathway interactions;Performance;Peripheral Nerve Stimulation;Peripheral Nervous System;Persons;Physiology;post stroke;Prediction of Response to Therapy;predictive modeling;Predictive Value;Process;Quality of life;Randomized;Rehabilitation therapy;Research;Research Personnel;Residual state;responders and non-responders;response;Selection for Treatments;Spinal;Spinal Cord;spinal reflex;Standardization;Stroke;stroke survivor;Supervision;targeted treatment;Testing;Time;tool;Training;Transcranial magnetic stimulation;treadmill;treadmill training;treatment effect;treatment response;United States National Institutes of Health;Variant;virtual;Walking;Work

PROJECT_TITLE: Neurophysiologic correlates of training-induced locomotor learning post-stroke


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative In settings with a high prevalence of HIV and other sexually transmitted infections, there is a vital public health imperative to understand and to reduce men's engagement in transactional sex and problematic alcohol use. This project will examine the potential for a savings-led intervention to reduce transactional sex and spending on alcohol while also strengthening economic security in low-income settings with a high burden of infectious diseases.

PI_NAMEs: THIRUMURTHY, HARSHA  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Africa South of the Sahara;Age disparity;AIDS prevention;Alcohol abuse;Alcohol consumption;Alcohols;antiretroviral therapy;Automobile Driving;Behavior;behavior change;behavior influence;Behavior Therapy;Behavioral;Behavioral Mechanisms;Chlamydia;Communicable Diseases;Complement;Control Groups;Data;Decision Making;design;discounting;Eastern Africa;economic behavior;economic outcome;Economics;Educational Subsidies;Effectiveness;Effectiveness of Interventions;empowerment;Expenditure;Female;female sex worker;financial incentive;financial literacy;follow-up;Future;Gambling;Goals;Gonorrhea;group intervention;Health;Health behavior;Health education;Heavy Drinking;High Prevalence;high risk;high risk men;high risk sexual behavior;HIV;HIV risk;Human Herpesvirus 2;improved;Incentives;Incidence;Income;Individual;infection burden;infection risk;innovation;interest;Intervention;Interview;Investments;Kenya;Link;Longterm Follow-up;Low income;low income country;Male Circumcision;Measures;Medical;men;Multiple Partners;Outcome;Participant;Perception;Periodicals;Pilot Projects;Policies;Policy Maker;pre-exposure prophylaxis;Prize;programs;psychologic;Public Health;Qualitative Methods;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Personnel;response;Rewards;Risk;Risk Behaviors;Risk Reduction;Role;Sampling;Savings;scale up;Security;Services;sexual relationship;Sexually Transmitted Diseases;Southern Africa;Surveys;Syphilis;Testing;Training;transactional sex;Unsafe Sex;Vocational Education;Woman;women versus men;Women's Health

PROJECT_TITLE: A savings intervention to reduce men's engagement in HIV risk behaviors

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Methamphetamine;Opioid Misuse and Addiction;Opioids;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: HANOI

ORG_COUNTRY: VIETNAM

ORG_FIPS: VM

ORG_NAME: HANOI MEDICAL UNIVERSITY

PHR: Public Health Relevant Statement  The twinned epidemics of opioid and methamphetamine use have been reported in the US and other countries such as Vietnam. We propose to develop and evaluate optimal combinations of evidence-based interventions to improve HIV outcomes and reduce methamphetamine use among people with opioid use disorders who are in methadone maintenance therapy. Lessons learned from this study may inform the development of responses in the US as well as other resourced and resourced-constrained settings.

PI_NAMEs: LE, GIANG M (contact);SHOPTAW, STEVEN J

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Achievement;adaptive intervention;addiction;Adoption;Alternative Therapies;Asia;Buprenorphine;Cities;Clinic;Clinical;Collaborations;comparative cost effectiveness;compare effectiveness;contingency management;cost effective;cost-effectiveness ratio;Country;design;Development;Disease;Drug abuse;Education;effectiveness evaluation;Enrollment;Ensure;Epidemic;Ethnography;Evidence based intervention;Funding;group counseling;Healthcare Systems;Heroin;high risk;HIV;HIV risk;hybrid type 1 design;implementation/effectiveness;improved;incremental cost-effectiveness;individual response;Injecting drug user;Intervention;Interview;Location;Maintenance;methadone treatment;Methamphetamine;methamphetamine use;Modeling;Monitor;motivational enhancement therapy;multidisciplinary;National Institute of Drug Abuse;North America;opioid epidemic;opioid injection;opioid use;opioid use disorder;opioid user;Outcome;Participant;Patients;personalized approach;Persons;primary outcome;Provider;Public Health;Randomized;recruit;Reporting;Research;Research Personnel;Resource-limited setting;Resources;response;Risk;Risk Behaviors;scale up;screening;Sequential Multiple Assignment Randomized Trial;stem;substance use;Tablets;Technology Transfer;Testing;therapy design;treatment strategy;trial design;Twin Multiple Birth;United States Substance Abuse and Mental Health Services Administration;Urine;Vietnam;Viral;Work

PROJECT_TITLE: Screen, Treat and Retain Meth-Using People with Opioid Use Disorders at MMT Clinics (STAR-OM)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Neuroblastoma;Neurosciences;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative My experience, productivity, qualifications, and accomplishments are critical for the successful implementation of clinical trials through the Dan L. Duncan Comprehensive Cancer Center’s Pediatric Cancer Program (DLDCCC PCP). My leadership accomplishments within the NCI- sponsored COG ensure the continued development and implementation of innovative clinical trials for pediatric oncology patients. The funding opportunity outlined in this application is essential for providing the dedicated time needed to continue fulfilling the mission of the DLDCCC.

PI_NAMEs: FOSTER, JENNIFER HAUNANI (contact)

PROGRAM_OFFICER_NAME: TAWAB-AMIRI, ABDUL

PROJECT_TERMS: Award;Biology;Board Certification;Cancer Control;Cancer Patient;career;Childhood;Childhood Solid Neoplasm;Clinical;Clinical Pharmacology;clinical trial implementation;Clinical Trials;Clinical Trials Network;Committee Members;Comprehensive Cancer Center;Consent;Dedications;Development;Developmental Therapeutics Program;early phase clinical trial;Enrollment;Ensure;experience;falls;Funding;Funding Opportunities;high risk;innovation;Institution;interest;Lead;Leadership;Malignant Childhood Neoplasm;meetings;member;Mentors;Mission;Monitor;Neuroblastoma;novel therapeutics;Oncologist;Oncology;Patients;Pediatric Hematologist;Pediatric Hematology;Pediatric Oncology;Pediatric Oncology Group;pediatric patients;Performance;phase I trial;Productivity;programs;Qualifying;Recurrent disease;Refractory Disease;Research;Research Personnel;Role;Scientist;Site;Solid Neoplasm;Specialist;Therapeutic Clinical Trial;Time;Toxic effect

PROJECT_TITLE: NCI Research Specialist (Clinician Scientist) Award


NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE External cues and sex chromosomes profoundly influence DNA methylation patterns in mouse pluripotent stem cells, yet the underlying mechanisms and their functional relevance remain incompletely understood. We recently discovered that male and female ESCs cultured in naïve conditions (2i) as well as female ESCs cultured in conventional conditions (serum/LIF) exhibit global hypomethylation with a concomitant erosion of genomic imprints, chromosomal instability and an impaired developmental potential due to suppressed MAPK signaling. Based on these strong preliminary data and the notion that the MAPK pathway plays crucial roles in early embryos, this R01 application seeks to explore how the MAPK pathway influences DNA methylation, chromosomal stability and developmental potential in mouse and human pluripotent cells with the goal to understand basic mechanisms and develop safer human stem cell models.

PI_NAMEs: HOCHEDLINGER, KONRAD  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;Affect;Alleles;Attenuated;blastocyst;BRAF gene;cell type;Cells;Chemicals;Chromosomal Instability;Chromosomal Stability;Cues;Data;Defect;Dependence;Development;DNA;DNA Methylation;Embryo;embryo culture;embryonic stem cell;Endowment;Environment;Epiblast;Epigenetic Process;epigenome;Exhibits;Female;Genes;Genetic Transcription;Genome Stability;genome wide methylation;Genomic Imprinting;Genomic Instability;Genomics;Goals;Human;human embryonic stem cell;human stem cells;Impairment;implantation;imprint;improved;In Vitro;in vivo;induced pluripotent stem cell;inhibitor;Karyotype;Knock-out;LIF gene;Link;Maintenance;male;MAP Kinase Gene;MAP2K1 gene;MAPK phosphatase;Measures;MEKs;Methylation;methylation pattern;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinase Kinases;Molecular;Mouse Embryonic Stem Cells;Mus;Mutation Analysis;natural Blastocyst Implantation;Pathway interactions;pharmacologic;Phenotype;phosphoproteomics;Play;pluripotency;Pluripotent Stem Cells;preimplantation;preservation;Process;Proteomics;Protocols documentation;Research Personnel;Role;self renewing cell;self-renewal;Serum;sex;Sex Chromosomes;Sex Differences;Signal Transduction;Somatotype;stem cell model;stemness;System;Testing;Titrations;tool;Up-Regulation;upstream kinase;Work;X Chromosome

PROJECT_TITLE: Dissecting mechanistic links between MAPK signaling, genomic hypomethylation and naive pluripotency

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative While the concept of the multiple-state GPCR activation model has been accepted in the pharmacological and structural biology communities, we lack an understanding of the roles of intermediate conformational states and their interactions with signaling partners such as Gabg, and as such, an understanding of the signaling efficacy. This proposed project, preceded by our development of receptor conformation-biased mutants, has led to a high-resolution conformational profile for the adenosine A2A receptor, well positioning us to study the individual intermediate conformational states, their interactions with G proteins, and consequent signaling. The completion of this project will promote our understanding of signaling diversity beyond a simple two-state ON/OFF switch model with implications for drug discovery based on GPCR and G protein conformational responses to ligands.

PI_NAMEs: YE, LIBIN  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: ADORA2A gene;Affinity;Agonist;Binding;Biological Assay;Biophysics;Cells;Characteristics;Communities;Complex;conformational conversion;Coupling;Cryoelectron Microscopy;Cyclic AMP;Data;Development;Dissociation;Drug Design;drug discovery;experimental study;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gas dynamics;Gases;Genetic;GTP-Binding Proteins;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Hydrolysis;In Vitro;Individual;inhibitor;innovation;insight;interfacial;Label;Lead;Ligands;Link;Maps;Measures;Mental Depression;Modeling;Molecular Conformation;molecular dynamics;mutant;Nature;neuropsychiatric disorder;NMR Spectroscopy;Nuclear Magnetic Resonance;Nucleotides;Outcome;Output;Parkinson Disease;Peptides;pharmacologic;Play;Positioning Attribute;Production;protein activation;Protein Conformation;Proteins;radioligand;receptor;Receptor Activation;Relaxation;Research;Resolution;response;Role;side effect;Signal Transduction;Sodium Chloride;stoichiometry;structural biology;Structure;Testing;therapeutic target;tool;transmission process;unnatural amino acids;Work

PROJECT_TITLE: The Role of Intermediate Conformations in G Protein-coupled Receptor Signaling

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Public Health Relevance The proposed research will study the heterogeneity of hippocampal-cortical dysfunction in the early stage of psychosis. The goal is the improved diagnosis and a better understanding of the disease mechanism of psychotic disorders.

PI_NAMEs: HECKERS, STEPHAN  (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Acute;Affect;Animal Model;Anterior;anti-epileptic agents;Blood flow;Brain;brain abnormalities;Chronic;Chronic Schizophrenia;clinical heterogeneity;Clinical Research;cohort;Data;Delusions;density;Diagnosis;Dimensions;Disease;Disease Pathway;Dissection;Dose;DSM-V;Early Diagnosis;early psychosis;Equilibrium;Evolution;experience;experimental study;Family;Frequencies;Functional disorder;Functional Imaging;Goals;Heterogeneity;Hippocampus;Hyperactivity;Image;improved;Individual;Intervention;Levetiracetam;Link;Longitudinal Studies;Maps;Memory;Memory impairment;Modeling;network dysfunction;Outcome;Pathway interactions;Patients;Performance;Persons;pharmacologic;Population;preclinical study;prevent;Prevention;Prevention strategy;Protocols documentation;Psychoses;psychotic;Psychotic Disorders;public health relevance;recruit;relational memory;Research;Resolution;Rest;restoration;Sampling;Schizophrenia;Schizophreniform Disorder;Severities;social deficits;Societies;Staging;Structure;Study models;Symptoms;Testing;Time;translational neuroscience

PROJECT_TITLE: Imaging Hippocampal Function in Psychosis

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE Lipoprotein (a) is a highly prevalent, genetic risk factor for both cardiovascular disease and calcific aortic valve stenosis. This grant focuses on generating novel information translating Lp(a) biological findings to clinical applications. Findings from this grant will result in diagnostic and therapeutic advances that will minimize incidence of cardiovascular disease and calcific aortic valve stenosis.

PI_NAMEs: TSIMIKAS, SOTIRIOS  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Address;Aortic Valve Stenosis;apolipoprotein B-100;apolipoprotein Lp(a+);attributable risk;Awareness;Binding;Biological;Biological Assay;Biology;Carbohydrates;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Centers for Disease Control and Prevention (U.S.);Cholesterol;Cholesterol Esters;Clinical;clinical application;clinical care;Clinical Chemistry;Clinical Data;Collaborations;Data Reporting;Data Set;Development;Diagnostic;Diagnostic Procedure;Educational workshop;Ensure;Enzyme-Linked Immunosorbent Assay;ethnic difference;follow-up;Generations;Genetic;genetic risk factor;Grant;Hospitals;human disease;Immunoassay;improved;Incidence;Individual;International;International System of Units;Kringles;Laboratories;Latex Bead;Lipoprotein (a);Manufacturer;Mass Spectrum Analysis;Measurement;Measures;Methodology;Methods;Monoclonal Antibodies;National Heart, Lung, and Blood Institute;novel;Outcome Study;Patient Care;Patients;Peptides;Phospholipids;polyclonal antibody;Population;Protease Domain;Protein Isoforms;racial difference;Reagent;Recommendation;Reference Standards;Reporting;Risk;Risk Factors;Role;service providers;Site;Standardization;Structure;Tandem Repeat Sequences;targeted treatment;Technology;Testing;Therapeutic;Translating;Triglycerides;validation studies;Work;working group;World Health Organization

PROJECT_TITLE: Translating Lp(a) biology to clinical applications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Clinical Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Primary Health Care;Women's Health Research

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Obstructed labor is accountable for 3-8% of the maternal deaths worldwide and, in many countries, is almost as prevalent today as it was 30 years ago. Cephalopelvic disproportion (CPD) is an inadequate size of the maternal pelvis, compared to the fetal head, which prevents the fetus from passing through the pelvic cavity during delivery causing obstructed labor and requires delivery via Caesarean section (C/S), which is not readily available at the time of labor to most women in low-resource settings around the world. This paper presents the use of anthropometry and 3D-camera technology, with or without ultrasound to develop novel, low-cost, safe, easy-to- use, scalable tools to assess risk of obstructive labor due to CPD in Ethiopian women.

PI_NAMEs: GLEASON, RUDOLPH L (contact);YIGEREMU, MAHLET

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: 3-Dimensional;Accountability;accurate diagnosis;Age;antenatal care;Anthropometry;Area;Assessment tool;beneficiary;Birth;care seeking;Caring;Cellular Phone;Cephalopelvic Disproportions;Cesarean section;Clinical;Clinical Research;cost;Country;Data;design;Detection;Eligibility Determination;Emergency Situation;Ensure;Ethiopia;Ethiopian;Family;feasibility testing;fetal;Fetus;follow-up;Gestational Age;girls;Goals;Head;Health care facility;Health Care Sector;health care settings;Health Personnel;high risk;High-Risk Pregnancy;Hospitals;human centered design;improved;India;Infrastructure;innovation;Intervention;Labor Onset;longitudinal, prospective study;Malnutrition;Maternal Mortality;Measurement;Measures;Methods;Morbidity - disease rate;Mothers;Nigeria;novel;obstetric fistula;Obstructed labor;Operative Surgical Procedures;Paper;Pelvic cavity structure;Pelvis;Perinatal mortality demographics;portability;Positioning Attribute;Pregnancy;pregnant;prevent;Primary Health Care;Protocols documentation;Public Health;Readiness;Recommendation;Reporting;Resource-limited setting;Risk;Risk Assessment;Rural;Rural Health Centers;Sampling;screening;smartphone application;Structure;Technology;Time;tool;Translating;Triage;Tribes;ultrasound;uptake;usability;Validation;validation studies;Woman

PROJECT_TITLE: PREVENTING MATERNAL MORTALITY FROM OBSTRUCTED LABOR


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Pancreatic neuroendocrine tumor (PNET) incidence is on the rise and remains an unmet clinical need. We have identified two new targets for this deadly disease and have a drug (in Phase I) that can interfere with core pathways that promote PNET. Through this proposal we will perform extensive pre-clinical evaluation of the utility of these targets and also identify biomarkers that would position us to initiate a tailored clinical study in the immediate future to positively impact treatment of patients suffering from the devastating PNET disease.

PI_NAMEs: AZMI, ASFAR S (contact);EL-RAYES, BASSEL

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: acquired drug resistance;aerobic glycolysis;Anabolism;analog;ATRX gene;beta catenin;Biological Assay;Biological Markers;biomarker identification;Biopsy;Blood;cancer cell;Cancer Etiology;Clinic;Clinical;Clinical Research;Clinical Trials;cofactor;Combined Modality Therapy;comparative genomic hybridization;CRISPR/Cas technology;cytotoxicity;DAXX gene;demethylation;density;Dependence;Development;Disease;DNA Methylation;Dose;Down-Regulation;drug resistance development;effective therapy;Enzymes;Excision;Failure;FDA approved;Fluorescent in Situ Hybridization;FRAP1 gene;Future;Genomics;Growth Factor;Growth Factor Receptors;Hereditary Disease;in vitro activity;in vivo;Incidence;Individual;inhibitor;Insulin;Islet Cell Tumor;Ligands;Link;Metabolic;Metabolic Pathway;Metabolism;Methylation;Modeling;Molecular;Molecular Analysis;mTOR Inhibitor;Mutation;neoplastic cell;Nicotinamide adenine dinucleotide;nicotinamide phosphoribosyltransferase;nicotinate;Nicotinic Acids;Normal Cell;Normal tissue morphology;novel;novel therapeutics;Oligonucleotide Microarrays;Operative Surgical Procedures;Organoids;overexpression;Oxidation-Reduction;p21 activated kinase;pancreas xenograft;Pathway interactions;patient derived xenograft model;patient population;Patient Selection;patient stratification;patient subsets;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Phase;phase I trial;PIK3CG gene;Placebos;Positioning Attribute;potential biomarker;pre-clinical;preclinical evaluation;preclinical study;predictive marker;prevent;Progression-Free Survivals;Proliferating;promoter;Proteins;PTK2 gene;Reaction;Receptor Signaling;Recurrence;Regimen;Resected;Resistance;resistance mechanism;response biomarker;Reverse Transcriptase Polymerase Chain Reaction;rho GTP-Binding Proteins;RNA Interference;Role;SDZ RAD;Signal Pathway;Signal Transduction;spheroids;standard of care;subcutaneous;Survival Rate;Therapeutic;therapy resistant;Time;Tissues;Toxic effect;treatment response;tumor;Tumor Biology;Tumor Cell Line;tumor xenograft;Unresectable;VHL gene;Von Hippel-Lindau Syndrome;Warburg Effect;Work

PROJECT_TITLE: A novel therapy for pancreatic neuroendocrine tumors

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Networking and Information Technology R&D (NITRD);Neurosciences;Stroke

ORG_CITY: RALEIGH

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: PROJECT NARRATIVE This proposal seeks support to develop a NextGen novel ionization method and variants thereof for biological mass spectrometry that will transform tissue imaging (molecular microscopy). Furthermore, the tissue imaging data will be derived from serial tissue sections and ablation based 3D imaging with multiple lines of biological readouts (e.g., neurotransmitters, lipids, glycans) providing new insights into important human health and disease (stroke, wound healing, cardiometabolic disease). In summary, we will establish a disruptive enabling bioanalytical technology through detailed characterization using real biological systems; this new technology and the underlying processes, hardware and software components will be fully documented and freely shared with the imaging community, and many of the proposed advances can readily be adapted by other MSI platform technologies to transform the entire MSI field since the MSiReader software is agnostic with respect to mass spectrometry platform, laser wavelength, biological system, or disease and is driven by the needs of the entire MSI community.

PI_NAMEs: MUDDIMAN, DAVID C. (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: 3-Dimensional;Ablation;Address;advanced analytics;Air;Algorithms;analytical tool;Atmospheric Pressure;Autoimmune Diseases;Biological;biological systems;brain tissue;Calibration;Cardiometabolic Disease;Charge;Chemicals;Code;Collaborations;Communities;Computer software;Cryoultramicrotomy;Data;Data Analyses;Data Set;Databases;Dedications;Derivation procedure;detection limit;Development;Disease;Dissociation;Educational workshop;Electrospray Ionization;Engineering;Ensure;Evolution;experience;Fiber Optics;Foundations;Funding;Goals;Health;Heart Diseases;Human;Image;imaging modality;imaging platform;Imaging technology;improved;Informatics;innovation;insight;ionization technique;Ischemic Stroke;Isomerism;Lasers;Licensing;Light;Link;Lipids;machine learning algorithm;Malignant Neoplasms;mass analyzer;mass spectrometer;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;Microscopy;model organism;Molecular;Motion;multidimensional data;Multimodal Imaging;Neurodegenerative Disorders;neurodevelopment;Neurotransmitters;new technology;next generation;novel;open source;operation;Optics;Paper;Pathway interactions;Peptides;Physiological;Play;Polysaccharides;Positioning Attribute;Preparation;preservation;Process;Publishing;Recording of previous events;Research;Resolution;Resource Sharing;Role;Sampling;Science;Series;Shapes;single cell analysis;Skin;software development;Solid;Solvents;Source;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Spottings;Stroke;Systems Biology;Techniques;Technology;technology development;technology platform;Three-Dimensional Imaging;Time;Tissue imaging;Tissues;Translating;Variant;Vendor;whole body imaging;wound healing;Zebrafish

PROJECT_TITLE: Development and Application of New Ionization Methods for Biological Mass Spectrometry

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: SAN MARCOS

ORG_NAME: CALIFORNIA STATE UNIVERSITY SAN MARCOS

PHR: PROJECT NARRATIVE BEARS is founded upon the knowledge that a diverse biomedical workforce is necessary to address the complex problems in biomedical research. Underrepresented minorities contribute to solving biomedical problems by increasing innovation, cooperation and productivity in research settings. As there is a strong need to reduce the racial and socioeconomical disparities in health, underrepresented minorities bring cultural competence and understand the issues among their demographic groups, which helps build trust with disadvantaged communities and improves the outreach of science among the general public.

PI_NAMEs: BROWN, TRACEY K;LUNA LOPEZ, CARLOS  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Academic support;Address;Admission activity;Awareness;Basic Science;Biomedical Engineering;Biomedical Research;biomedical scientist;Biotechnology;bridge program;California;career;college;Communication;Competence;Complex;cultural competence;Degree program;Development;Doctor of Medicine;Doctor of Philosophy;early awareness;education research;education resources;Educational workshop;empowerment;Event;Faculty;Fostering;General Population;Goals;graduate school;health disparity;high school;improved;innovation;Inosine Diphosphate;Interdisciplinary Study;interest;Knowledge;Leadership;matriculation;Measurable;Medical;Mentors;Mentorship;National Institute of Biomedical Imaging and Bioengineering;neighborhood disadvantage;Orthopedic Surgery;outreach;peer;peer coaching;Productivity;programs;racial disparity;recruit;Research;Research Project Grants;Research Training;Science;Scientist;Series;skills;social;socioeconomic disparity;Students;Talents;Training;Trust;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Universities

PROJECT_TITLE: Building Early Awareness and Research in Science (BEARS)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity;Prevention;Sleep Research

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Obesity is commonly associated with chronic sleep disruption and excessive daytime sleepiness which significantly increase the cardiometabolic risk and reduce the productivity at work. The research proposed in this application seeks to identify a novel brain circuit connecting metabolic disorders to sleep-wake regulation.

PI_NAMEs: CUI, HUXING  (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Address;Adipocytes;Affect;Animals;Area;Attenuated;Behavior;Brain;Brain Mapping;Brain region;cardiometabolic risk;Cardiovascular Physiology;cell type;Chronic;Coupled;Cre-LoxP;Data;Development;diet-induced obesity;Diurnal Rhythm;Electroencephalography;Electrophysiology (science);energy balance;Excessive Daytime Sleepiness;excessive weight gain;Exhibits;feeding;Fiber;Genetic;Goals;Human;Hypothalamic structure;in vivo;innovation;Investigation;Knowledge;Lateral Hypothalamic Area;Leptin;leptin receptor;Leptin resistance;Link;Literature;LoxP-flanked allele;Maps;Measurement;Mediating;Metabolic;Metabolic Diseases;Metabolic hormone;Motor Activity;Mus;neural;neural circuit;Neurons;Neurosciences;novel;novel strategies;Obese Mice;Obesity;obesity development;optogenetics;Patients;Periodicity;Persons;Photometry;Physiological;Physiological Processes;poor sleep;Preoptic Areas;prevent;Productivity;programs;Publishing;receptor;Regulation;Research;Research Proposals;Risk;Risk Factors;Role;Signal Transduction;Site;Sleep;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep onset;sleep quality;sleep regulation;Sleep Wake Cycle;Techniques;Technology;Testing;Ventral Tegmental Area;Viral;Wakefulness;Weight Gain;wireless;Work

PROJECT_TITLE: Decoding brain circuit underlying metabolic regulation of sleep-wake behavior

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project narrative During infection, SARS-CoV-2 induces formation of an endoplasmic reticulum (ER)- derived organelle (called the double-membrane vesicle) to support replication of the viral genome, although the molecular basis of this process remains enigmatic. Upon assembly of the replicated genome with virus structural proteins, the newly-formed viral progeny undergoes secretion via a poorly-define mechanism. Accordingly, this application will elucidate how SARS-CoV-2 exploits two ER membrane host factors (RTN3 and SigmaR1) to promote viral replication and secretion, two essential infection steps.

PI_NAMEs: TSAI, BILLY  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Anti-viral Agents;Biology;Cells;Complex;COVID-19;COVID-19 pandemic;Cytosol;Data;Development;Disease Progression;Drug Modulation;Endoplasmic Reticulum;endosome membrane;Endosomes;experimental study;FDA approved;Genetic Transcription;Genome;genomic RNA;Golgi Apparatus;Impairment;Infection;insight;Integration Host Factors;Life Cycle Stages;Link;loss of function;Membrane;Membrane Fusion;Membrane Proteins;Methods;Molecular;multiple myeloma M Protein;Nature;Nonstructural Protein;Organelles;particle;Pathway interactions;polypeptide;Process;Protein S;Proteins;receptor mediated endocytosis;recruit;RNA;Role;SARS-CoV-2 infection;Shapes;Site;Structural Protein;Structure;Testing;Translating;Translations;Vesicle;Viral;Viral Genome;viral genomics;Viral Proteins;Viral Structural Proteins;Virus;Virus Assembly;Virus Diseases;Virus Replication

PROJECT_TITLE: How infectious SARS-CoV-2 exploits two ER membrane proteins to promote infection

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PI_NAMEs: HOMMEL, JONATHAN DEAN (contact)

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Active Learning;Address;Assessment tool;Behavior Therapy;Bioinformatics;Biomedical Research;Clinical;clinical encounter;Clinical Research;Clinical Sciences;Clinical Trials;Communication;Communities;community engaged research;Competence;conflict resolution;Development Plans;Devices;Discipline;doctoral student;Education;Educational Curriculum;Educational workshop;Entrepreneurship;Environment;Ethical Issues;Evaluation;experience;global health;Goals;graduate student;Health;Health Policy;Healthcare;Human;human disease;Human Subject Research;improved;Individual;innovation;insight;Intervention;Journals;Knowledge;knowledge integration;Leadership;learning materials;Machine Learning;Measures;Mediation;Medical;Medical Students;Mentors;Modality;Moon;multidisciplinary;National Center for Advancing Translational Sciences;National Research Service Awards;online course;Outcome;pedagogical content;Pharmaceutical Preparations;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;programs;Publications;Research;Research Design;Research Personnel;Research Project Grants;Research Training;Rice;Science;Self Efficacy;skills;student participation;Students;Technical Expertise;Testing;theories;Therapeutic;TNFSF15 gene;Training;training opportunity;Training Programs;Translating;Translational Research;translational scientist;United States National Institutes of Health;vaccinology;Workforce Development;workforce needs

PROJECT_TITLE: NRSA Training Core


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE (RELEVANCE TO PUBLIC HEALTH) This study is aimed at investigating in detail the pathogenic role of IL-1-driven inflammatory pathway in anaplastic large cell lymphoma (ALCL). Gaining insight into the mechanisms activating this inflammatory pathway in ALCL as well as its exact involvement in the malignant cell transformation may lead to improved understanding of the molecular circuitry that drives tumor survival and shapes the tumor microenvironment. The therapeutic potential of targeting the pathway will be tested using a specific kinase inhibitor and a recombinant inhibitory protein, which may lead to novel strategies for targeted therapy in this unique group of lymphoid malignancies.

PI_NAMEs: YANG, YIBIN  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Address;Aggressive Clinical Course;anakinra;anaplastic lymphoma kinase;antagonist;Anti-Inflammatory Agents;B-Cell Lymphomas;cancer cell;Cell Line;Cell Survival;cell transformation;Characteristics;Clinical;clinical efficacy;Collection;CRISPR library;CRISPR screen;Cutaneous;cytokine;Cytology;Data;Development;Disease;Exhibits;FDA approved;Gene Expression;Genes;Genetic;Goals;Growth;Human;IL1R Signaling Pathway;IL1R1 gene;Immunity;improved;In Vitro;in vitro testing;Inflammation;Inflammatory;inhibitor;insight;Interleukin-1;Interleukin-1 alpha;Interleukin-1 Receptors;Internal Breast Prosthesis;Intervention;IRAK4 gene;Janus kinase;Ki-1 Large-Cell Lymphoma;kinase inhibitor;Knowledge;Large-Cell Lymphomas;Lesion;Libraries;loss of function;Lymphoma cell;Lymphoproliferative Disorders;Malignant - descriptor;Malignant lymphoid neoplasm;Malignant Neoplasms;Mature T-Lymphocyte;Mediator;Modeling;Molecular;Morphology;Mus;Mutation;Natural Immunity;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Oncogenic;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Phosphorylation;Play;pre-clinical;Premalignant Cell;Proteins;Public Health;receptor;receptor expression;Recombinants;Recurrence;Regimen;Regulation;Role;Sampling;Seroma;Shapes;Signal Transduction;small molecule;Solid Neoplasm;STAT3 gene;Subgroup;T-Cell and NK-Cell Neoplasm;targeted treatment;Testing;Therapeutic;TNFRSF8 gene;Toxic effect;Transcription Coactivator;transcriptome sequencing;tumor;tumor microenvironment;Validation;Xenograft Model

PROJECT_TITLE: Investigating the IL-1R Pathway in Anaplastic Large Cell Lymphoma for Targeted Therapy

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE Morphogenesis is a universally important process in growth and development that involves changes in cell shape and position that must occur at precisely the right time and place and sex, yet a comprehensive understanding of the regulatory mechanisms controlling the cellular machinery is still lacking. In this project, we will determine how morphogenesis of the four-celled tail tip in C. elegans males is temporally scheduled to occur precisely at a key developmental transition point and what effector genes are targeted by the "master regulator" male-specific transcription factor DMD-3 to execute morphogenesis. This study will lead to a model for how genes interact to produce biological form, thus providing a basis to identify key conserved components that control morphogenesis and which could thus provide new targets for pharmaceuticals or other interventions to aid wound healing or mitigate the effects of morphogenetic faults contributing to birth defects or cancer.

PI_NAMEs: FITCH, DAVID H. A. (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Address;Adolescent;Adult;Animals;Binding;Biological;Biological Assay;Biology;Caenorhabditis elegans;Candidate Disease Gene;candidate identification;cell behavior;Cell fusion;cell motility;Cell Physiology;Cell Polarity;Cell Shape;Cells;ChIP-seq;chromatin immunoprecipitation;Co-Immunoprecipitations;Congenital Abnormality;Cytology;Cytoplasm;Cytoskeleton;Data;Data Set;Defect;Development;Developmental Process;Embryo;Event;Evolution;experimental study;Foundations;gene conservation;gene interaction;gene regulatory network;Gene Targeting;Genes;Genetic;genetic manipulation;Genetic Transcription;Genomics;Goals;Growth and Development function;Human;in vivo;innovation;Intervention;Knowledge;Label;Laboratories;Lasers;Link;Lobular Neoplasia;male;Malignant Neoplasms;Mammals;Medicine;MicroRNAs;migration;Modeling;Molecular;Morphogenesis;Mutation;Nematoda;network models;novel;Outcome;Pathway interactions;Pharmacologic Substance;Play;Positioning Attribute;Post-Translational Regulation;Process;programs;Proteins;pubertal timing;Regulation;Regulator Genes;Resolution;Role;scaffold;Schedule;sex;sex determination;sexual dimorphism;Shapes;Signal Transduction;Specificity;Structure;System;Tail;Techniques;Testing;theories;Time;Tissues;trafficking;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transduction Gene;Ubiquitination;Untranslated RNA;Vesicle;Work;wound healing

PROJECT_TITLE: Control and Implementation of a Morphogenetic Program

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Cancer;Kidney Disease;Rare Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative REDD1 upregulation activates autophagy through inhibition of mTORC1. We propose to evaluate the roles that REDD1 plays in renal cell carcinoma progression, the mechanisms of PIM kinase inhibitor-mediated REDD1 induction, and the link between REDD1 expression and sensitivity to autophagy inhibition. Our overall goal is to identify novel strategies to target autophagy for renal cell carcinoma therapy.

PI_NAMEs: CAREW, JENNIFER S;NAWROCKI, STEFFAN T (contact)

PROJECT_TERMS: Address;Apoptosis;Apoptotic;ATP Synthesis Pathway;Autophagocytosis;cancer cell;cancer type;Cell Survival;chemotherapy;Chemotherapy and/or radiation;Clear Cell;Clear cell renal cell carcinoma;Clinical;clinical application;clinical translation;Clinical Trials;Clinical Trials Design;clinically actionable;clinically relevant;Competence;CRISPR/Cas technology;Data;Dependence;Dose;Drug resistance;endoplasm;endoplasmic reticulum stress;Exhibits;Failure;FRAP1 gene;Genetic;Goals;Homeostasis;Hydroxychloroquine;Hypersensitivity;Hypoxia;Immune checkpoint inhibitor;improved outcome;inhibition of autophagy;inhibitor;Kidney;kinase inhibitor;Link;Lysosomes;Malignant - descriptor;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Mediator;Medical;Metabolic stress;Modeling;mouse model;novel;novel strategies;Organelles;overexpression;Pathogenesis;Pathway interactions;patient derived xenograft model;Patient Selection;Patient-Focused Outcomes;pharmacologic;Phosphotransferases;PIM1 gene;Play;predictive marker;Protein Biosynthesis;Proteins;proto-oncogene protein pim;rational design;Recycling;Regimen;Renal Cell Carcinoma;Reporting;Resistance;response;Role;standard of care;Starvation;Stress;Testing;Therapeutic;transcription factor;transcriptome;tumor;tumor progression;Tumor Suppressor Proteins;Up-Regulation

PROJECT_TITLE: Targeting Lysosomal Vulnerabilities in Renal Pathogenesis

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: SANTA BARBARA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project narrative Contact-dependent growth inhibition (CDI) is an important mechanism of inter-cellular competition found in a variety of Gram-negative bacterial pathogens. This proposal utilizes genetic, biochemical and structural analyses to gain mechanistic insights into CDI toxin activities. This research will significantly increase our understanding of the evolution and ecology of bacterial pathogens and could inform novel antimicrobial strategies.

PI_NAMEs: GOULDING, CELIA ;HAYES, CHRISTOPHER S. (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Acids;Active Sites;Acyl Carrier Protein;Acylation;Acyltransferase;Amino Acid Sequence;Anti-Bacterial Agents;antimicrobial;Bacteria;Bacterial Genome;Bacterial Toxins;Binding;Biochemical;biophysical analysis;biophysical techniques;C-terminal;Calorimetry;cell killing;Cell surface;Cells;Chimera organism;Citrobacter rodentium;Communication;Complex;Crystallization;Crystallography;Cysteine;Cytoplasm;Data;Deaminase;Ecology;Escherichia coli;Evolution;Family;functional plasticity;Gammaproteobacteria;Genetic;genetic approach;Goals;Gram-Negative Bacteria;Growth;human pathogen;Immunity;In Vitro;insight;Length;Lipopolysaccharides;Lysine;Mediating;Membrane;Membrane Proteins;Modification;Molecular;Molecular Genetics;Molecular Target;novel;novel strategies;pathogen;pathogenic bacteria;Pathway interactions;Peptide Hydrolases;Peptides;Predisposition;protein complex;protein protein interaction;Protein Secretion;Proteins;Providencia;Publishing;Reaction;receptor;receptor binding;reconstitution;Research;Resolution;Ribonucleases;Series;Site;Structure;Substrate Specificity;Surveys;System;Testing;Toxin;Transfer RNA;Variant;Yersinia

PROJECT_TITLE: Function of novel antibacterial toxins

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Lung;Lung Cancer;Neurosciences;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The proposed research seeks to develop a functional and mechanistic understanding of how GABAergic neuron modulation by nicotine contributes to the brain metastasis of lung cancer. Here, we aim to define the newly discovered functional role of GABAergic neuron in supporting brain metastasis and provides a scientific basis for pursuing the inhibition of nicotine-activated GABA shunt as a novel therapeutic strategy that could significantly improve the treatment and prevention of brain metastasis in cancer patients with past and current smoking history. Information gleaned from this work may be used in the generation of future clinical trials focusing on therapeutic interventions for preventing brain metastasis.

PI_NAMEs: WU, SHIH-YING  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Address;Animal Model;Brain;Brain Neoplasms;Cancer Biology;Cancer Patient;career;cell growth;Cells;Clinical;Clinical Trials;clinically significant;Coculture Techniques;Communication;Communities;Data;Data Analyses;Death Rate;density;Development;efficacy testing;exosome;experience;Family;Future Generations;GABA Receptor;GABA transporter;gamma-Aminobutyric Acid;Genes;Glean;Goals;Immunologic Surveillance;improved;In Vitro;in vivo;Incidence;inhibitor;innovation;Intake;Laboratories;Leadership;lung lesion;Malignant neoplasm of lung;member;Mentors;Mentorship;Metabolic;Metabolism;Metastatic malignant neoplasm to brain;Microglia;MicroRNAs;Molecular;mouse model;neoplastic cell;neuronal growth;Neurons;Nicotine;non-smoker;novel;novel strategies;novel therapeutic intervention;Pathologic;Pathway interactions;Patients;perineural;Phase;prevent;Prevention;Prevention strategy;Production;Prognosis;Publishing;Recurrent tumor;Research;Resources;Risk Factors;Role;Shunt Device;skills;Smoker;Smoking;Smoking History;Synapses;synaptogenesis;System;Techniques;Therapeutic Intervention;therapeutically effective;Training;translational cancer research;treatment strategy;tumor growth;tumor progression;Universities;WNT Signaling Pathway;Work

PROJECT_TITLE: Nicotine promotes perineural brain metastasis by activating GABAergic neurons

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE OVERALL Genetic complexity and cellular heterogeneity are the greatest challenge to understanding and treating cancer. The Jackson Laboratory Cancer Center is focused on resolving this complexity through applying advanced computational and genomic approaches on novel organismal, cellular, and computational models of cancer, and by investigating the in vivo tumor-stromal-immune interactions. We translate our findings to the clinic through the provision of genetic and genomic technologies to key clinical collaborators.

PI_NAMEs: PALUCKA, ANNA KAROLINA  (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Abbreviations;anti-cancer research;Basic Cancer Research;Biology;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer education;cancer genomics;Cancer Model;Cancer Science;Capital;care providers;career;Cell model;Center for Translational Science Activities;Chromatin;Clinic;Clinical;clinical development;Clinical Investigator;Clinical Trials Cooperative Group;collaborative environment;Communities;Community Clinical Oncology Program;Complex;Computational Biology;Computational Science;Computer Models;Development;Diagnostic;Discipline;Disease;DNA Sequence Alteration;Education;empowerment;Engineering;Epigenetic Process;Faculty;frontier;functional genomics;Funding;Genetic;Genetic Engineering;Genetic Models;Genome;Genomic approach;Genomic Instability;Genomics;Goals;Grant;Growth;Heterogeneity;Human;human model;humanized mouse;Immune;Immunology;improved;in silico;In Vitro;in vivo;Individual;innovation;Institution;Israel;Laboratories;Leadership;Learning;Maine;Malignant Neoplasms;Medical center;Medicine;member;microbiome;Mission;model development;Modeling;Mus;Names;NCI Center for Cancer Research;novel;Oncology;operation;organizational structure;Parents;patient derived xenograft model;Phenotype;precision oncology;programs;recruit;Research;Research Personnel;Resource Development;Resource Sharing;Resources;RNA;Role;Services;single cell genomics;single cell technology;Southwest Oncology Group;Stromal Neoplasm;Structure;Students;success;synergism;Systems Biology;Talents;Technology;technology platform;The Jackson Laboratory;Therapeutic;therapeutic development;tissue reconstruction;Translating;translational impact;Translational Research;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Vision

PROJECT_TITLE: Cancer Center Support (CORE) Grant

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: AIRHART, SUSAN  (contact)

PROJECT_TERMS: Abbreviations;Administrative Personnel;Administrator;Advisory Committees;Agreement;Award;Budgets;Cancer Center;Cancer Center Support Grant;cancer education;cancer research center director;candidate identification;career;Center for Translational Science Activities;Clinical;Clinical Research;Collaborations;Communication;Computational Science;Coordinating Center Administration;cost effective;Dedications;Development;Education;Ensure;Evaluation;Faculty;Funding;Funding Agency;Future;Genetic Engineering;Genome;Goals;Grant;Growth;Health Services Research;innovation;Institution;Israel;Laboratories;Leadership;Malignant Neoplasms;Medical center;meetings;member;Mentors;microbial genomics;Names;operation;Organization administrative structures;outreach;Phenotype;Pilot Projects;Policies;precision oncology;Process;Program Development;programs;quality assurance;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Science;Services;single cell technology;Southwest Oncology Group;Strategic vision;symposium;Technology;The Jackson Laboratory;Training;translational cancer research;Translational Research;Travel;Work

PROJECT_TITLE: Cancer Center Administration


PI_NAMEs: WRAY, CHARLES G (contact)

PROJECT_TERMS: anti-cancer research;Area;Baltimore;Basic Science;Biology;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer education;cancer genetics;cancer genomics;cancer therapy;career;career development;CLIA certified;Clinical;clinical application;clinical decision-making;Clinical Informatics;Collaborations;Communication;Communities;Community Clinical Oncology Program;Complex;Comprehensive Cancer Center;Continuing Education;continuing medical education;curriculum development;Decision Making;design;E-learning;Education;Education and Outreach;educational atmosphere;Educational Curriculum;Educational process of instructing;Educational workshop;Event;experience;Faculty;faculty mentor;Fostering;Foundations;functional genomics;Funding;Future;Generations;Genetic;Genome;genomic data;Genomic medicine;Genomics;Goals;graduate student;Growth;Health Insurance Portability and Accountability Act;high school;High School Student;Informatics;innovation;Institution;Journals;Knowledge;knowledgebase;Laboratories;Laboratory Research;Leadership;Learning Module;life-long learning;Maine;Malignant Neoplasms;member;Mentors;Mentorship;Molecular Biology;New Mexico;Oncologist;Oncology;organizational structure;outreach program;Participant;Patients;Postdoctoral Fellow;Procedures;Program Development;programs;Provider;recruit;Research;Research Personnel;Research Training;Resource Informatics;Resources;Rural;Scientist;skills;Southwest Oncology Group;Strategic Planning;student mentoring;summer student;Testing;The Jackson Laboratory;tool;Training;Training Activity;training opportunity;Training Programs;translational applications;Translational Research;tumor;undergraduate student;Universities;virtual;Work

PROJECT_TITLE: Cancer Education and Career Enhancement Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: AMHERST

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE To design an effective design a multivalent TB vaccine, nanoparticles will be decorated with established recombinant antigens using a next-generation adjuvant system that induces seamless, spontaneous and biostable antigen surface display. Key parameters of particle formation will be examined and the vaccine will be benchmarked against Bacillus Calmette–Guérin (BCG) vaccination and tested in mouse and guinea pig animal models of TB infection.

PI_NAMEs: LOVELL, JONATHAN F (contact);OBREGON, ANDRES

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Adjuvant;Aerosols;Animal Model;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Bacille Calmette-Guerin vaccination;BCG Live;Benchmarking;Binding;Biochemical;Biological;Biological Assay;C3HeB/FeJ Mouse;Cavia;Cells;Cobalt;comparative efficacy;COVID-19 vaccine;Data;density;design;Development;Dose;draining lymph node;efficacy evaluation;Formulation;Freeze Drying;Generations;guinea pig model;Immune;Immune response;Immunization;immunogenicity;improved;In Vitro;in vivo;Inbred BALB C Mice;Individual;innovation;Intramuscular;Intranasal Administration;Label;Liposomes;Lower respiratory tract structure;Lung;Molecular;mouse model;Mucosal Immune Responses;Mucous Membrane;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;nano;nanoliposome;nanoparticle;Nanotechnology;Nature;next generation;NIH Program Announcements;Oryctolagus cuniculus;Outcome;particle;Peptides;Performance;Phase;Phospholipids;Porphyrins;Proteins;QS21;Recombinants;research clinical testing;response;Route;Saponins;Serum;Surface;Surface Antigens;System;T cell response;Testing;thermostability;Time;Toxic effect;Tuberculosis;Tuberculosis Vaccines;Upper respiratory tract;uptake;Vaccination;Vaccine Adjuvant;Vaccine Antigen;vaccine development;vaccine discovery;Vaccines

PROJECT_TITLE: Developing a Multivalent Subunit Particle Vaccine Against Tuberculosis


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Diabetes;Nanotechnology;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Molecular mechanisms for diabetes impaired fracture healing are largely unknown. Ciliopathies have very recently been identified as key modulators of the relationship between diabetes and metabolic physiology. We will pursue this relationship to better understand diabetic fracture healing and as a mechanistic tool for the engineering design of novel therapeutic aids for the benefit of diabetic patients suffering from bone fractures.

PI_NAMEs: GRAVES, DANA T;YANG, SHUYING  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Address;Affect;Animals;bone fracture repair;Breathing;Cells;Chondrocytes;Cilia;ciliopathy;cilium biogenesis;controlled release;cost;Data;Development;Devices;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Disease;Dislocations;Down-Regulation;Effectiveness;engineering design;Event;experimental study;Formulation;FOXO1A gene;Fracture;Future;Genes;Goals;healing;Health;high risk;Histologic;Human;Hydrogels;Impairment;improved;In Vitro;in vivo;Injectable;Injections;Insulin;Insulin-Dependent Diabetes Mellitus;Insulin-Like Growth Factor I;Jeune syndrome;Knowledge;Link;Measures;Mechanics;Metabolic;microCT;mimetics;Molecular;Mus;Mutation;nanofiber;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nuclear;Osteoblasts;Osteogenesis;Pathogenesis;Pathologic;Patients;Physiology;preclinical study;Pseudarthrosis;repaired;response;Role;Short Rib-Polydactyly Syndrome;side effect;Signal Pathway;Signal Transduction;Technology;Testing;Therapeutic;tool;transcription factor;Up-Regulation

PROJECT_TITLE: Treatment and Mechanisms of Diabetic Fracture Healing

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: CHUANG, JEFFREY HSU-MIN (contact)

PROJECT_TERMS: Abbreviations;Achievement;Address;Algorithms;analysis pipeline;analytical tool;anti-cancer research;Architecture;Area;Artificial Intelligence;Big Data Methods;Bioinformatics;Biometry;Cancer Biology;Cancer Center;cancer genomics;Cancer Research Infrastructure;Cancer Research Project;Clinical;Collection;Complex;Computational Science;computer scientist;Computer software;cost;Data;Data Analyses;data platform;data portal;Data Science;Data Set;Databases;design;Development;experience;Experimental Designs;Faculty;Funding;Genomics;Goals;Grant;High Performance Computing;Hybrids;Individual;Information Technology;Infrastructure;Laboratories;Machine Learning;Malignant Neoplasms;member;Mentorship;metabolomics;multidisciplinary;Names;Ownership;Procedures;programs;Quantitative Trait Loci;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;response;scientific computing;Services;single cell genomics;skills;software development;Software Engineering;Statistical Methods;statistics;System;tool;Training;translational cancer research;Tumor Biology

PROJECT_TITLE: Computational Sciences Shared Resource