NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PHOENIX

ORG_NAME: BANNER HEALTH

ORG_STATE: AZ

PHR: Project Narrative Leaders from the Alzheimer’s Prevention Initiative (API) and Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) Trials have come together to conduct a potentially license-enabling prevention trial, using clinically informative Alzheimer’s disease biomarkers and other assessments to evaluate the promising amyloid plaque-busting antibody treatment aducanumab in cognitively unimpaired 65-80 year-old persons with a positive amyloid PET scan. The deliberately ambitious proposal is intended to 1) find an approved Alzheimer’s prevention therapy as early as 2023, ahead of the National Plan to Address Alzheimer’s Disease goal to “prevent Alzheimer’s disease by 2025; 2) introduce the use of these biomarkers to test and approve prevention therapies in almost everyone who, based on their biological tests or genetic risk, are at increased risk; and 3) help make it possible to conduct prevention trials in at risk persons even before they have extensive amyloid plaques, when some treatments may have their greatest benefit. It is intended to capitalize on a public-private partnership with the makers of aducanumab, NIH support, $5-10 million dollars in philanthropy; enable us to secure access to this promising drug and secure most of the financial support from our industry partner; provide a public resource of data and biological samples to help the field find even better ways to test prevention therapies; have the maximum public benefit; and prevent Alzheimer’s disease as soon as possible.

PI_NAMEs: AISEN, PAUL S.;ALEXANDER, ROBERT C;JOHNSON, KEITH A.;LANGBAUM, JESSICA BROOKE;REIMAN, ERIC MICHAEL (contact);SPERLING, REISA A.

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: abeta oligomer;Acceleration;Address;Aducanumab;Affect;Affective;Alleles;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Antibodies;Antibody Therapy;apolipoprotein E-4;asymptomatic Alzheimer's disease;behavioral outcome;Binding;Biological;Biological Markers;Biological Testing;Blinded;Characteristics;Clinical;clinical effect;Cognition;Cognitive;cognitive benefits;Collaborations;Communication;cost;Data;data resource;Disclosure;Dose;Double-Blind Method;Excision;Financial Support;Functional disorder;Genetic;Genetic Risk;Goals;Health;Image;Impaired cognition;Impairment;Incidence;industry partner;Intervention;Learning;Licensing;Life;Magnetic Resonance Imaging;Measurement;Memory Loss;Modeling;Moods;Nature;Older Population;open label;Outcome;Participant;Pathology;Persons;Pharmaceutical Preparations;Phase;Phase Ib Clinical Trial;Phase Ib Trial;phase III trial;Placebo Control;placebo group;Placebos;Populations at Risk;Positron-Emission Tomography;post-market;pre-clinical;prevent;Prevention Guidelines;Prevention therapy;Prevention trial;primary outcome;Procedures;programs;public-private partnership;Quality of life;Randomized;Reporting;Resources;Risk;Safety;Sampling;Secure;Senile Plaques;social relationships;Surrogate Endpoint;Surrogate Markers;tau Proteins;Test Result;Testing;therapy adverse effect;Time;Titrations;treatment group;United States National Institutes of Health;Visit

PROJECT_TITLE: API A4 Alzheimer's Prevention Trial

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;Women's Health Research

ORG_CITY: ATHENS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ZOOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Narrative Mosquitoes are the most important arthropod vectors of disease-causing pathogens. Proposed studies will characterize the receptor binding preferences and functions of two types of neurohormones, insulin-like peptides and ovary ecdsysteroidogenic hormone, that regulate female mosquito reproduction. Results will identify new potential targets for disrupting female reproduction for potential use in vector control.

PI_NAMEs: STRAND, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Aedes;Area;Arthropod Vectors;Arthropods;Award;Binding;Biology;Blood;Brain;Cells;Culicidae;Data;Dengue Fever;Development;Digestion;Disease;Disease Vectors;Ecdysteroids;egg;Egg Yolk Proteins;Endocrinology;Event;Exhibits;Family;Family member;Fat Body;feeding;Female;Funding;G-Protein-Coupled Receptors;Genes;Goals;Growth Factor;hormonal signals;Hormones;Human;human disease;human pathogen;Ingestion;innovation;insight;Insulin;insulin-like peptide;Leucine-Rich Repeat;Ligands;Link;Medial;Midgut;Mosquito Control;mosquito reproduction;Names;Neurohormones;Neuropeptides;novel strategies;Nutrient;Oocytes;Oogenesis;Outcome;Outcome Study;Ovary;pathogen;Pathway interactions;permissiveness;Phase;Play;Population;preference;Process;product development;Production;Property;receptor;receptor binding;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Regulation;Reproduction;reproductive;Reproductive Biology;response;Role;Signal Pathway;Signal Transduction;spatiotemporal;sugar;Syndrome;Testing;Time;Tissues;transmission process;uptake;vector;vector control;vector mosquito;Vertebrates;Virus;Vitellogenins;Work;Yellow Fever;ZIKA;Zika Virus

PROJECT_TITLE: Endocrinology of Mosquito Reproduction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)M]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: CINCINNATI

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative Idiopathic pulmonary fibrosis (IPF) is an incurable, disabling, and often fatal disease characterized by the accumulation of myofibroblasts predominantly in the peripheral areas of the lung. Identifying WT1-driven gene targets involved in fibroblast activation will establish the pathological role of WT1 in fibroblast activation and help to develop innovative treatment strategies for patients with fibrotic lung disease.

PI_NAMEs: MADALA, SATISH K (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Adult;American;antifibrotic treatment;Apoptotic;Area;Attenuated;BCL2L1 gene;BCL3 gene;Biochemical;Biological Assay;Bleomycin;Cells;ChIP-seq;Cicatrix;Clinical;Collagen;Coupled;Data;Deposition;Diagnosis;Disabling;Disease;drug candidate;druggable target;experimental study;Extracellular Matrix;FDA approved;Fibroblasts;Fibrosis;fibrotic lung;fibrotic lung disease;Funding;Gene Targeting;Genes;Genetic;Genetic Transcription;Goals;idiopathic pulmonary fibrosis;Impairment;improved;In Vitro;in vivo;inhibitor;innovation;insight;Knock-out;Knockout Mice;Knowledge;Lead;Lesion;loss of function;Luciferases;Lung;lung lesion;Mediator;Methods;Molecular;mouse model;multidisciplinary;Mus;MYCN gene;Myofibroblast;nintedanib;novel;novel therapeutic intervention;novel therapeutics;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathologic Processes;Patients;Peripheral;pharmacologic;Phase;Play;PLK1 gene;prevent;preventive intervention;Process;Production;programs;promoter;Publishing;Pulmonary Fibrosis;pulmonary function;Pulmonary Pathology;Regulation;Reporting;Resolution;Role;small molecule inhibitor;Testing;therapeutic evaluation;Therapeutic Intervention;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transforming Growth Factor alpha;Transgenic Mice;treatment strategy;Up-Regulation;Work;WT1 gene;Zinc Fingers

PROJECT_TITLE: WT1 REGULATION OF PULMONARY FIBROSIS

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: The ability to learn to perform specific motor movements is critical for many aspects of life, and is dysregulated in a range of neurological conditions such as Parkinson’s disease, Huntington’s diseases, and dementia. Dopaminergic cells provide a reinforcement signal to promote action learning, but how the brain uses these signals to explore the action space based on past rewarding experiences is not clear. The goal of the proposed project is to broaden our understanding of how dopaminergic cells act to promote action learning in mammals.

PI_NAMEs: TANG, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Affect;Animals;Area;Behavior;behavior influence;Behavioral;Behavioral Mechanisms;Behavioral Paradigm;behavioral response;behavioral study;Brain;career development;Computing Methodologies;Corpus striatum structure;Cues;Data;Dementia;diagnostic development;diagnostic strategy;Dissection;Dopaminergic Cell;dopaminergic neuron;Dorsal;Environment;experience;experimental study;Faculty;Genetic;genetic approach;Goals;Huntington Disease;Image;Impairment;Joints;Knowledge;Label;Lead;Learning;learning strategy;Life;Mammals;Mediating;Mentors;Mentorship;Methods;Modeling;Monitor;Motor;Movement;Mus;Nervous System Disorder;neural;neural correlate;Neurologic;neuromechanism;Neurons;Neurosciences;Operant Conditioning;optogenetics;Parkinson Disease;pars compacta;Pathway interactions;Pattern;Performance;Phase;Population;Positioning Attribute;Process;programs;Psychological reinforcement;Recording of previous events;reinforced behavior;Research;Resolution;Resource Development;response;Rewards;Role;sequence learning;Shapes;Signal Transduction;Substantia nigra structure;System;Technical Expertise;Techniques;Testing;tool;Training;treatment strategy;Universities;Ventral Striatum;Ventral Tegmental Area;Viral;Work

PROJECT_TITLE: Dissecting the Action Learning Process with Dopaminergic Reinforcement

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Human paraneoplastic neurological disorders (PNDs) are debilitating disorders of the central nervous system that involve autoimmune encephalitis. The autoimmune encephalitis is triggered by cancer in PNDs, but it is also an unanticipated side effect of anti-cancer immunotherapies, broadening the scope of the problem. I have identified, using a new robust approach, previously elusive pathogenic PND antigens, and in this proposal I strengthen the link to autoimmune encephalitis and identify the molecular cues and pathways that may serve as therapeutic entry points to diminish the immune inflammation.

PI_NAMEs: MANDEL-BREHM, CALEIGH  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Anatomy;antigen-specific T cells;Antigens;Area;Autoantibodies;Autoantibody binding;Autoimmune;Autoimmune Diseases of the Nervous System;Autoimmune encephalitis;Autoimmune Responses;Autoimmunity;Bacteriophages;Bioinformatics;Brain;brain cell;Brain region;Brain Stem;cancer immunotherapy;CD8B1 gene;cell motility;cell type;Cells;Cellular Neurobiology;Central Nervous System Diseases;Cerebellum;Child;Childhood;Clinical;clinical predictors;CNS autoimmunity;Cues;Cytotoxic T-Lymphocytes;Data;Dependence;diagnostic biomarker;Disease;Disease Progression;Encephalitis;Environment;Epitopes;Excision;Follow-Up Studies;Gene Deletion;Genes;glymphatic system;Goals;Histocompatibility Antigens Class I;Human;Immune;immune cell infiltrate;Immunity;Immunohistochemistry;Immunologist;Immunology;Immunoprecipitation;Inflammation;Infrastructure;Interferon Type II;Invaded;Knockout Mice;Knowledge;lens;Link;Malignant Neoplasms;Maps;Mediating;Mentors;MHC Class I Genes;Mission;Molecular;Molecular Immunology;mouse genetics;mouse model;Mus;neoplastic cell;Nervous System Disorder;Nervous System Paraneoplastic Syndromes;neural;Neurobiology;neuroimmunology;neuroinflammation;Neurologist;neuronal circuitry;Neurons;novel;novel marker;Outcome;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Pattern;Phage Display;Phage ImmunoPrecipitation Sequencing;Phase;Prognosis;Proteins;Publishing;Recombinants;recruit;Refractory;Research;Research Personnel;Resolution;response;Role;Route;segregation;side effect;Signal Transduction;single cell sequencing;skills;Specificity;Symptoms;Syndrome;T cell response;T-Lymphocyte;Testing;Therapeutic;Time;tumor;Up-Regulation;Workplace

PROJECT_TITLE: Molecular understanding of self immunity in the brain


ADMINISTERING_IC: OD

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Narrative The major goal of this application is to maintain the CPRC as a relevant national and international research resource for the support of comparative studies in the biomedical and behavioral sciences.This proposal is seeking support to make available to the research community valuable conventional and SPF IO rhesus, and related resources. With continued NIH support, the CPRC will remain a significant national research resource and will be able to provide healthy Indian-origin rhesus monkeys of defined genetic and virological background to NIH-sponsored research programs.

PI_NAMEs: BURGOS-RODRIGUEZ, ARMANDO GIL;LOPEZ, MARCOS ;MARTINEZ, MELWEEN I. (contact);SARIOL, CARLOS A

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Accreditation;Agreement;Anatomy;animal care;Animal Experimentation;Animal Model;Animal Welfare Act;Animals;Applied Research;Area;Behavior;Behavioral Sciences;behavioral study;biodefense;Biological;Biological Sciences;Biological Warfare;Biomedical Research;Breeding;Caribbean region;Caring;Collaborations;Collection;Communicable Diseases;Communities;comparative;Comparative Study;computerized;COVID-19;COVID-19 pandemic;Databases;Development;Education;Etiology;Funding;Genetic;Genetic Variation;Genomics;germ free condition;Goals;Grant;Health;higher education;Human;human disease;IACUC;improved;India;Infrastructure;intergenerational;International;Island;Laboratories;Macaca mulatta;Medical;Medicine;Metabolic;Minority-Serving Institution;Modeling;Monitor;Morphology;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Dental and Craniofacial Research;National Institute of Mental Health;Neurosciences;nonhuman primate;operation;outreach program;Pathologic;Physiological;Plants;Policies;Population;Pre-Clinical Model;Primates;programs;Provider;Publications;Puerto Rico;Research;Research Personnel;Research Project Grants;Resources;Rhesus;Science;Services;Simian T-lymphotropic virus 1;SIV;skeletal;Skeleton;Stress;Structure;Students;Study models;Technology;Training;Translational Research;Type D Retrovirus;undergraduate student;United States Department of Agriculture;United States National Institutes of Health;Universities;vaccine development;Veterinary Medicine;Viral;virology;Virus

PROJECT_TITLE: Caribbean Primate Research Center Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 OTC1-J (56)]


NIH_SPENDING_CATS: Genetics;HIV/AIDS

PI_NAMEs: MARTINEZ, MELWEEN I. (contact)

PROJECT_TERMS: Affect;Agreement;Anatomy;Animal Experimentation;Animals;Applied Research;Area;Behavior;Behavioral;Behavioral Sciences;behavioral study;biodefense;Biological;Biological Warfare;Biology;Biomedical Research;Breeding;Caribbean region;Caring;Collaborations;Collection;Communities;Comparative Study;computerized;COVID-19;COVID-19 pandemic;Databases;design;Development;Developmental Biology;DNA Sequence;drug development;Drug Targeting;Ensure;Exhibits;Funding;Gene Mutation;Genes;Genetic;genetic analysis;Genetic Variation;Genome;Goals;Grant;Health;Human;human disease;improved;India;Infrastructure;Institution;intergenerational;International;Island;Laboratories;Life Cycle Stages;Macaca;Macaca mulatta;Medical;member;Microsatellite Repeats;Modeling;Monitor;Monkeys;Morphology;multidisciplinary;Neurosciences;Neurosciences Research;nonhuman primate;operation;Orthologous Gene;Pathologic;Pathology;Personal Satisfaction;Physiological;Population;Pre-Clinical Model;Primates;programs;Publications;reference genome;Research;Research Project Grants;Resources;Rhesus;Science;skeletal;Skeleton;Stress;stressor;Structure;Translational Research;United States National Institutes of Health;vaccine development;virology;Well in self

PROJECT_TITLE: Resources at the Caribbean Primate Research Center


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Microbiome;Pediatric;Women's Health Research

PHR: Narrative The goal of the Applied Research Component (ARC) proposed here is continues with the successful Translational Science Initiative (TSI) at the CPRC. The close evolutionary relationship between humans and nonhuman primates (NHPs) is reflected by many common features in their genetics, physiology, and biochemistry, and these similarities make NHPs especially valuable as model systems for biomedical research. During the execution of this project we will characterize the vaginal microbiome in non-pregnant primates and will assess their association with the multiple-body microbiome dynamics in gestation and postpartum in rhesus macaques. This will contribute to understand maternal-infant transmissibility and compare changes associated to SPF and conventional animals. As captivity is thought to significantly alter the overall microbial community composition leaving additional bio exclusion, social interactions, environmental exposure as well as exposure to human's other important factors modulating the animal microbiome and its health.

PI_NAMEs: SARIOL, CARLOS A (contact)

PROJECT_TERMS: Advisory Committees;Affect;animal colony;Animal Housing;Animal Husbandry;Animals;Antibiotics;Applied Research;Archaea;Area;Bacteria;Biochemistry;Biological Models;biological systems;Biomedical Research;Birth;Breeding;Caribbean region;Certification;Chronic Disease;comparative;Complement;cost;Development;Diet;Disease;Drug Approval;Education;Environment;Environmental Exposure;Eukaryota;Exclusion;Exposure to;Failure;Fostering;Funding;Funding Opportunities;fungus;Future;Genetic;germ free condition;Goals;gut microbiome;Health;Human;Immune;Immunity;Immunology;improved;Infant;Infectious Agent;innovation;Investigation;Knowledge;Lead;Letters;Link;Macaca;Macaca mulatta;Microbe;microbial;microbial community;microbial composition;microbiome;microbiota;microorganism;Minor;multiple omics;Newborn Infant;nonhuman primate;pathogen;Pharmacologic Substance;Physiology;Pilot Projects;Postpartum Period;Practice Management;Pregnancy;Primates;programs;Progress Reports;Prokaryotic Cells;Protozoa;Publications;reproductive;Research;Research Activity;research and development;Research Project Grants;Research Support;resilience;Resources;response;Scientist;Shapes;Simian Retroviruses;SIV;Social Interaction;Students;success;therapeutic development;Time;Translating;translation to humans;translational model;translational potential;Translational Research;translational research program;Type D Retrovirus;United States National Institutes of Health;Urbanization;vaginal microbiome;Virus

PROJECT_TITLE: Translational Science Initiative


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Behavioral intervention such as exercise has been shown to mitigate pathogenesis of neural disease such as Alzheimer's and Parkinson's disease, and other form neurodegeneration. I have developed a training plan and research project that will bridge my current training in genetic and molecular approaches of studying synaptic biology to exercise mediated models of neural plasticity. My ultimate goal is to utilize this approach to identify novel molecular pathways and signaling factors that mediate neural plasticity as potential targets for therapeutic applications, which aligns with the Brain Initiative on Neurotherapeutics and Mechanisms shaping neuronal circuitry.

PI_NAMEs: WOODS, BRANDON  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Adult;Alzheimer's Disease;Applied Genetics;Architecture;Behavior Therapy;Behavioral;Biological Assay;Biology;Brain;BRAIN initiative;Calcium;career;Career Choice;Cell Adhesion;Cell Physiology;cell type;Cellular Morphology;Critical Thinking;Curiosities;Cytoskeleton;Disease;Doctor of Philosophy;Drosophila genus;Environment;Excision;Exercise;fascinate;FMR1 gene;Foundations;gain of function;Generations;Genes;Genetic;genetic analysis;genetic approach;Genetic Transcription;Goals;Hippocampus;Human;Individual;insight;interest;Larva;Lead;Learning;Logic;loss of function;Mediating;Messenger RNA;MicroRNAs;Mind;model organism;Modeling;Molecular;Molecular Analysis;Morphogenesis;Morphology;Nerve Degeneration;Nervous System;Nervous System Disorder;neural;neural circuit;neural model;neurogenesis;neuromechanism;Neuromuscular Junction;neuronal circuitry;Neuronal Plasticity;Neurons;novel;optogenetics;Parkinson Disease;Pathogenesis;Pathway interactions;Phase;Phenotype;Physiological;Physiology;Positioning Attribute;Post-Transcriptional Regulation;posttranscriptional;Process;programs;prospective;Research Project Grants;response;ribosome profiling;Role;screening;Shapes;Signal Transduction;skills;Solid;sound;Speed;Synapses;Synaptic plasticity;Synaptic Vesicles;System;targeted treatment;Technical Expertise;Testing;Therapeutic;Thinking;Time;tool;Training;transcription factor;Translations;Vesicle;Work

PROJECT_TITLE: miRNA Control of Synaptic Stability and Structural Plasticity


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Substance Misuse

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Substance use disorders are a significant public health issue, and one of the leading causes of drug relapse is exposure to stress. This project investigates specific neuronal subpopulations involved in anxiety-like stress responses with the long-term goal of understanding their contribution to relapse. In doing so, we hope to uncover new potential therapeutic targets in the treatment of maladaptive stress responses including affective and substance use disorders.

PI_NAMEs: WILLIFORD, KELLIE M (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;addiction;Affect;Affective;American;Amygdaloid structure;Anxiety;anxiety-like behavior;Area;Award;Beds;Behavioral Assay;biological adaptation to stress;Biological Assay;Brain;Brain Mapping;Budgets;Businesses;Calcium;career;Cell Nucleus;Cell Physiology;cell type;Cells;Characteristics;Chronic stress;Clinical;cocaine craving;conflict resolution;coping;Corticotropin-Releasing Hormone;cost;Custom;D Cells;Data;design;Devices;Drug Exposure;drug relapse;Drug usage;experience;experimental study;Exposure to;Extinction;Fellowship;Fiber;Foundations;Goals;Imaging Techniques;improved;in vivo;innovation;insight;Institution;Intervention;knock-down;Learning;Light;Measures;Mediating;Mental Depression;Mental disorders;Mentors;Microscopy;Modeling;Molecular;Neurons;Neuropeptides;new therapeutic target;optogenetics;Pharmaceutical Preparations;Phase;Phosphotransferases;Photometry;Population;Post-Traumatic Stress Disorders;Postdoctoral Fellow;prevent;Productivity;protein kinase C-delta;Proteins;Public Health;Publishing;Rabies;recruit;Relapse;Reporter;Research;Research Personnel;Research Project Grants;Resolution;restraint stress;Rodent Model;Role;Self Administration;Signal Transduction;skills;small hairpin RNA;Societies;Stress;Stressful Event;Substance abuse problem;Substance Use Disorder;substance use treatment;System;Techniques;therapeutic target;Time;Treatment outcome;Work

PROJECT_TITLE: Brain Network States Underlying Cocaine Craving


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: CLEVELAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Transcranial electric stimulation (TES) is a non-invasive method to treat multiple neural disorders through low amplitude electric fields through the brain, but the mechanisms are unknown. We propose to explain the mechanism of TES by a novel electric field coupling effect between neurons.

PI_NAMEs: DURAND, DOMINIQUE M (contact)

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: Affect;Animals;Behavior;behavioral study;Biology;Biophysics;Brain;BRAIN initiative;Brain region;Cephalic;clinical application;Clinical Trials;Cognition;cognitive performance;Coupling;Development;Disease;electric field;Electric Stimulation;Electrodes;Electrophysiology (science);epileptiform;experimental study;extracellular;Extracellular Space;Genetic Complementation Test;Goals;Hippocampus;Image;Imaging Techniques;improved;In Vitro;in vivo;insight;Laboratories;Link;Measures;Mediating;Methods;Microdialysis;Modality;motor disorder;neural;neural network;neural recruitment;neural stimulation;neuromechanism;Neurons;neuroregulation;novel;optogenetics;Osmolar Concentration;Play;Protocols documentation;recruit;Reporting;Research;response;Role;Seizures;Sleep;Slice;Speed;success;Synaptic Transmission;Techniques;Technology;Testing;Therapeutic;Transgenic Mice;voltage

PROJECT_TITLE: Cellular and Neural Network Mechanism of Transcranial Electric Stimulation


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: The proposed research will adapt CPT into a brief format using empirical methods. This project is relevant to Veterans’ health because will improve treatment effectiveness, reduce attrition, and improve efficiency, enabling providers to treat more Veterans with need. This proposal is directly responsive to the 2021 HSR&D mental health priorities to increase the engagement and retention of Veterans in evidence-based therapies for PTSD and to develop innovative and efficient models of healthcare delivery. It addresses the cross-cutting HSR&D Implementation Science priority to use a theory-based method to improve uptake of effective practices. It is also directly responsive to the VA National Center for PTSD’s operational priorities to develop adapted treatments that attend to patient preferences and to improve treatment efficiency, effectiveness, and engagement.

PI_NAMEs: SRIPADA, REBECCA KAUFMAN (contact)

PROJECT_TERMS: Abbreviations;Address;Adherence;Age;Characteristics;clinical practice;clinically significant;Cognition;Cognitive;design;Distress;Dose;Dropout;Drops;DSM-V;effective intervention;Effectiveness;effectiveness testing;effectiveness trial;Elements;Engineering;Ensure;evidence base;Evidence based treatment;Exclusion Criteria;experience;Experimental Designs;experimental study;follow-up;Future;Goals;Health;Health Priorities;Health Services Accessibility;implementation science;improved;improved outcome;Individual;innovation;Institute of Medicine (U.S.);Intervention;late life;Logistics;Measures;Mediating;Mediator;medical specialties;Mental Health;Methodology;Methods;multi-component intervention;multiphase optimization strategy;novel;Outcome;Participant;Patient Preferences;Performance;Personal Satisfaction;personalized intervention;personalized medicine;Persons;physically handicapped;post 9/11;Post-Traumatic Stress Disorders;premature;Process;Productivity;Provider;Psychotherapy;Quality of life;Randomized;reduce symptoms;Research;Research Priority;Service delivery model;Severities;sex;substance use;suicidal risk;Symptoms;System;telehealth;Testing;theories;Therapeutic;Time;Training Programs;Trauma;Treatment Effectiveness;treatment response;uptake;Veterans;Work

PROJECT_TITLE: Using the Multiphase Optimization Strategy to Adapt Cognitive Processing Therapy

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_CITY: CANANDAIGUA

ORG_NAME: VETERANS AFFAIRS, UNITED STATES DEPARTMENT OF

ORG_STATE: NY

PHR: We will refine a cognitive-behavioral therapy for loneliness and substance use disorder (CBT-L/SUD) then assess its feasibility and acceptability first through a small single-arm trial, then a small randomized clinical trial. Data from these trials will provide data to inform treatment satisfaction, and feasibility of study procedures, outcome measurement, and treatment delivery. Findings will be used to inform a larger, fully-powered Merit Award application testing the effects of CBT-L/SUD.

PI_NAMEs: ASHRAFIOUN, LISHAM  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;AODR mortality;arm;Award;Behavior;Behavioral;Behavioral Model;behavioral response;Belief;Caring;Cessation of life;Chronic Disease;Clinical;Cognitive;cognitive testing;Cognitive Therapy;Coping Skills;COVID-19;craving;Data;design;Development;Diagnostic Factor;Dissemination and Implementation;effective intervention;Emotional;Evidence based intervention;Feasibility Studies;Feedback;Health Personnel;Health Services Accessibility;High Prevalence;high risk;Household;improved;Individual;innovation;Intervention;intervention delivery;Knowledge;Life Expectancy;Loneliness;Manuals;Marriage;Measurement;Measures;Mental Health;Mental Health Services;Meta-Analysis;Methodology;Morbidity - disease rate;mortality;neglect;new therapeutic target;Outcome;Outcome Assessment;Outcome Measure;Overdose;Pain;pain reduction;Participant;Persons;Pharmaceutical Preparations;physical conditioning;Pilot Projects;Population;Primary Care;Procedures;programs;provider factors;psychosocial;Psychosocial Factor;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recovery;recruit;reduced substance use;Rehabilitation therapy;Relapse;relapse risk;Reporting;Research;Research Support;Risk;Risk Factors;Risk Reduction;Rural;satisfaction;Sleep disturbances;Social Distance;social engagement;Social Functioning;Social Interaction;Social isolation;Social Network;Social Perception;social situation;social stigma;social stressor;Social support;substance use;Substance Use Disorder;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Technology;telehealth;Testing;Therapeutic Intervention;Translating;treatment program;trend;Veterans;Work

PROJECT_TITLE: Addressing loneliness and substance use with telehealth CBT


ADMINISTERING_IC: HD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Pediatric;Rare Diseases;Tuberculosis

ORG_CITY: Madison

ORG_NAME: SALUS DISCOVERY, LLC

ORG_STATE: WI

PHR: Project Narrative Proper diagnosis is key to effective tuberculosis (TB) treatment, but there exist specific barriers to effective TB testing in low resource settings, especially in children. Thus, the goal of this project is to adapt our current point-of-care (POC) TB diagnostic assay to be sensitive enough for use in children, who often present with paucibacillary disease. Specifically, we will perform assay optimization and a small-scale pilot study of clinical sensitivity in Phase I that will evaluate the overall effectiveness of our assay technology, informing the next iteration of improvements prior to larger pediatric study in Phase 2.

PI_NAMEs: MULLINS, BRIANNA  (contact);WARRICK, JAY WYATT

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Adult;Age;aspirate;Back;Benchmarking;Biological;Biological Assay;Biological Markers;Biological Sciences;Cause of Death;CD4 Lymphocyte Count;Cell Wall;Cessation of life;Child;Childhood;Clinical;clinical research site;Clinical Sensitivity;Collection;commercialization;cost;Data;design;Detection;Development;Device or Instrument Development;Devices;Diagnosis;Diagnostic;diagnostic assay;diagnostic biomarker;Diagnostic Procedure;Diagnostic Sensitivity;diagnostic tool;Disease;Effectiveness;Emerging Technologies;Enrollment;Evaluation;Feedback;first-in-human;Foundations;Freezing;Funding;Generations;Glycolipids;Goals;high volume manufacturing;HIV;HIV/AIDS;human study;Immunocompromised Host;improved;Incidence;interest;Intuition;Laboratories;lateral flow assay;Letters;lipoarabinomannan;lymph node biopsy;Marketing;Measures;mycobacterial;new technology;participant enrollment;pathogen;Patients;pediatric patients;Performance;Phase;Pilot Projects;point of care;Population;Preparation;Process;Qualifying;Reagent;Recommendation;Recording of previous events;research clinical testing;Resource-limited setting;Route;Running;sample collection;Sampling;Sensitivity and Specificity;Small Business Innovation Research Grant;Source;South Africa;Sputum;Stomach;success;Technology;Testing;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;tuberculosis treatment;Urine;user-friendly;wearable device;Work

PROJECT_TITLE: Enhancing Pediatric Diagnosis of Tuberculosis with FLOW Technology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-V(12)]


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Shared decision making is the first overarching principle for the treat to target guidelines for rheumatoid arthritis (RA) and has been proposed as a potential mechanism to reduce health disparities, however there is little evidence to inform effective ways to implement this practice in the care of Veterans with RA. The purpose of this project is to evaluate the effectiveness of a multi-component shared decision making intervention on RA disease activity, adherence to RA medications and patient knowledge of RA. The proposed research will contribute to fundamental knowledge about how to effectively foster shared decision making across varied VA rheumatology clinical settings to improve patient disease outcomes and experience; and support clinicians to engage patients in meaningful ways with the ultimate goal to improve health, reduce disability, and eliminate disparities.

PI_NAMEs: BARTON, JENNIFER L (contact)

PROJECT_TERMS: Address;Adherence;arthritis therapy;Audiotape;Awareness;benefit sharing;Caring;Clinic;Clinical;Cluster randomized trial;Collaborations;comorbidity;Complex;Conflict (Psychology);Data;Decision Aid;design;disability;Disability disparity;Disease;Disease Outcome;Disease remission;Disparity;disparity elimination;disparity reduction;Educational process of instructing;effective intervention;Effectiveness;effectiveness evaluation;effectiveness study;effectiveness testing;Enrollment;ethnic minority;Ethnic Origin;experience;Exposure to;Failure;Female;Fostering;Future;General Population;Goals;Guidelines;health care quality;health disparity;health equity;health literacy;Health Services;Healthcare;high risk;High Risk Woman;implementation barriers;implementation facilitators;improved;indexing;innovation;Intervention;intervention delivery;Interview;Knowledge;literacy;male;Measures;men;Methodology;Methotrexate;mortality;mortality risk;multi-component intervention;novel;novel strategies;Outcome;pandemic disease;Participant;patient engagement;patient oriented;Patient Outcomes Assessments;Patients;personalized decision;Persons;Pharmaceutical Preparations;Phase;Population;post intervention;primary outcome;Public Health;Qualitative Evaluations;Quality of Care;Quality of life;Race;racial minority;Randomized, Controlled Trials;Recommendation;Reduce health disparities;Research;Research Personnel;Rheumatoid Arthritis;Rheumatology;routine care;secondary outcome;shared decision making;Site;Speed;Structure;Subgroup;telehealth;Testing;Therapeutic immunosuppression;Time;tool;Training;Translations;Treatment outcome;trial design;uptake;Veterans;virtual delivery;White Women;Work

PROJECT_TITLE: Implementation of shared decision making in rheumatoid arthritis: A stepped wedge, cluster-randomized trial

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


ORG_CITY: LEEDS

ORG_NAME: NORTHAMPTON VA MEDICAL CENTER

PHR: Over the past two decades, an increasing number of Veterans have used VA maternity benefits for their pregnancy care. As part of the VA maternity care benefit, Veterans are provided a maternity care coordinator (MCC) to aid in their navigation of health care services both inside and outside of the VA during their pregnancies. While the MCC program offers support to women during pregnancy, racial and ethnic disparities remain in delivery outcomes and in pregnancy, labor, and delivery support among Veterans. This study examines the impact of the social determinants of health among Veterans’ of color enrolled in VA maternity care and who also had a cesarean delivery. We will use these findings to inform a pilot intervention that seeks to enhance the MCC model with doula services in effort to provide continuous pregnancy support for Veterans at the greatest risk for cesarean delivery.

PI_NAMEs: MATTOCKS, KRISTIN M. (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Affect;attenuation;Behavioral;Birth;black women;care coordination;Caring;Cesarean section;Childbirth;Chronic stress;Clinical;Color;Communities;Congresses;cost;Data;Development;Discipline of obstetrics;Discrimination;Disparate;Disparity;disparity reduction;Education;Educational process of instructing;Enrollment;Ensure;ethnic disparity;ethnic minority;Ethnic Minority Women;experience;feasibility testing;Frequencies;Future;Grant;Health;health care availability;health care service;health disparity;health equity;Hospitals;implementation outcomes;improved;Individual;Inequality;Influentials;innovation;Institution;Intervention;Interview;Investigation;Leadership;Link;Maternal Health;maternal stress;Medical;Methodology;Methods;Modeling;Not Hispanic or Latino;novel;Obstetric Delivery;Outcome;Perinatal;perinatal outcomes;perinatal period;postpartum care;Postpartum Period;Poverty;preference;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;prenatal;Prenatal care;Proctor framework;programs;Public Health;Quality of Care;Quality-Adjusted Life Years;racial disparity;racial minority;racial minority women;racism;Repeat Cesarean Section;Research;Risk;Risk Factors;Role;Self Efficacy;Services;social;social determinants;social health determinants;Statutes and Laws;Structure;Surveys;United States;United States Department of Veterans Affairs;Vaginal delivery procedure;Veterans;Visit;White Women;Woman;women of color;Women's Health Services;Work

PROJECT_TITLE: Engaging Veterans in Developing an Intervention to Address Racial Disparities in Cesarean Sections

STUDY_SECTION_NAME: Social Determinants of Health[HS2A]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Brain Disorders;Breastfeeding, Lactation and Breast Milk;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Epilepsy;Maternal Health;Neurodegenerative;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Pregnancy;Prevention;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Seizure risk during pregnancy increases as drug clearance changes throughout pregnancy, often resulting in the need for increased dosing of anti-seizure medication in pregnant women; however, increased dosing also increases the risk of established negative outcomes to the fetus. This grant will use previously collected data and new measures from existing samples from the clinical study Maternal Outcomes and Neurodevelopmental Effects of Anti-Epileptic Drugs (MONEAD), animal data, in vitro studies, and an external validation cohort with sampling at new critical timepoints to determine the mechanistic basis of alterations in antiseizure medication concentrations during pregnancy and lactation. The outcomes of this effort will enable physiological-based modeling and approaches to optimize antiseizure medication dosing and decrease seizure risk during pregnancy while limiting unnecessary exposure (risk) to the fetus and breastfeeding child.

PI_NAMEs: BIRNBAUM, ANGELA K (contact);PENNELL, PAGE BUCKHANNAN

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Affect;animal data;Animal Model;Animals;anti-epileptic agents;Anticonvulsants;autism spectrum disorder;Basic Science;Blood flow;Breast Feeding;Breastfed infant;Child;Child Development;Clinical;clinical care;Clinical Data;Clinical Research;Cognitive;cohort;Cohort Studies;Conceptions;Congenital Abnormality;Data;Data Set;Development;Dose;drug clearance;Drug Exposure;drug exposure in utero;Drug Kinetics;Drug Monitoring;early pregnancy;Enzymes;Epilepsy;Evaluation;Exposure to;fetal;Fetal Tissues;Fetus;First Pregnancy Trimester;Glucuronosyltransferase;Goals;Grant;Human Milk;In Vitro;Individual;Infant;Kidney;Knowledge;Lactation;lamotrigine;Late pregnancy;Levetiracetam;liver metabolism;Measurement;Measures;Methods;Modeling;Mothers;neurodevelopmental effect;Organ;Outcome;Partition Coefficient;Pharmaceutical Preparations;pharmacokinetic model;Physiological;Plasma;Population;post pregnancy;Postpartum Period;precision medicine;predictive modeling;Pregnancy;pregnant;Pregnant Women;prenatal exposure;prevent;prospective;Renal clearance function;response;Risk;Risk Assessment;Route;Safety;Sampling;Seizures;side effect;simulation;Site;study population;Teratogens;Testing;Therapeutic;Time;Tissues;tool;Toxic effect;Translating;Up-Regulation;Validation;Visit;Woman

PROJECT_TITLE: Physiological-based Pharmacokinetics Approach to Determine the Extent of Drug Exposure of Antiseizure Medications During Pregnancy and Breastfeeding


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE The proposed study will combine qualitative and ecological momentary assessment methods to conduct an in- depth examination of polysubstance use among people who use illicit opioids. Knowledge gained will contribute to scholarship regarding polysubstance use at the person and event levels. Findings about proximate patterns of polysubstance can be used to inform overdose prevention strategies.

PI_NAMEs: LORVICK, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: PARKER, ERIN MARGARET

PROJECT_TERMS: addiction;African American;African American population;Alcohol consumption;Alcohols;Benzodiazepines;Cessation of life;Characteristics;Classification;Cocaine;Collaborations;Communicable Diseases;Communities;community based research;County;Data;Dependence;Development;Drug Combinations;Drug usage;Ecological momentary assessment;Epidemic;Epidemiology;Event;experience;Feasibility Studies;Funding;Future;Grain;handheld mobile device;illicit opioid;Individual;Investigation;Knowledge;Life;marginalized population;Measures;Medicine;Methods;Mobile Health Application;Motivation;Neighborhoods;next generation;Opioid;opioid overdose;opioid use;opioid user;Overdose;overdose death;overdose prevention;overdose risk;overdose risk behaviors;Pattern;Persons;Pharmaceutical Preparations;Play;polysubstance use;Prevention strategy;Principal Investigator;Productivity;Psychiatrist;Publishing;Qualitative Methods;Research;Research Personnel;Risk Behaviors;Role;Sampling;Scholarship;Shapes;social factors;sociologist;statistics;structural determinants;substance abuse treatment;substance use;substance user;time use;Treatment outcome;trend;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: A mixed-methods study of polysubstance use to inform opioid overdose prevention

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

PHR: UMN K12 Program Project Narrative This K12 institutional career development program supports two years of mentored research and training in translational science for highly-promising early-stage faculty at the University of Minnesota and partner institutions. The K12 Scholars are trained to increase the long-term public health impact of their research and to become the next generation of leaders in translational science and research by also including training in communication skills, leadership, team science and wellbeing. The program seeks to train a cadre of outstanding research faculty representing diverse backgrounds, fields of expertise and types of science, drawing on the breadth and depth of faculty and expertise at the University of Minnesota.

PI_NAMEs: INGBAR, DAVID H (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Active Learning;Animals;Applications Grants;Award;career;career development;Characteristics;Clinical Research;Clinical Sciences;college;Communication;Communities;community engagement;Competence;Dentistry;design;Development;Disadvantaged;Discipline of Nursing;dissemination science;Education;Effectiveness;Ensure;Evaluation;experience;Funding;gateway course;Generations;Grant;health data;Health Sciences;Healthcare;human subject;implementation science;Individual;innovation;Institution;Investigation;Leadership;Medical center;medical schools;Medicine;Mentored Clinical Scientist Development Program;mentoring community;Mentors;Minnesota;multidisciplinary;National Center for Advancing Translational Sciences;Nursery Schools;peer coaching;Personality Assessment;Pharmacy facility;Positioning Attribute;Productivity;professor;programs;Public Health;Reproducibility;Research;Research Personnel;Research Project Grants;responsible research conduct;Schools;Science;skill acquisition;skills;Talents;Time;Training;Translational Research;translational research program;translational scientist;Twin Cities;Universities;university student;Veterinary Medicine

PROJECT_TITLE: CTSA K12 Program at University of Minnesota

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-1 (01)]


ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: UMN Postdoctoral Narrative The Clinical and Translational Science Institute (CTSI) postdoctoral program trains the next generation of scientists to speed application of scientific discoveries to improve human health. Scholars will participate in 2 years of mentored research, individualized curriculum, and professional development activities highlighting our institutional strengths in leadership, community engagement, data science, team science and effective communication skills.

PI_NAMEs: FULKERSON, JAYNE ALLYN (contact)

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TITLE: CTSA Postdoctoral T32 at University of Minnesota


PHR: UMN Predoctoral T32 Narrative The Clinical and Translational Science Institute (CTSI) predoctoral program trains the next generation of scientists to speed application of scientific discoveries to improve human health. Scholars will participate in 2 years of mentored research, individualized curriculum, and professional development activities highlighting our institutional strengths in leadership, community engagement, data science, team science and effective communication skills.

PROGRAM_OFFICER_NAME: DIBELLO, ANTHONY THOMAS

PROJECT_TERMS: Minnesota;pre-doctoral;Universities

PROJECT_TITLE: CTSA Predoctoral T32 at University of Minnesota


ADMINISTERING_IC: ES

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Sleep Research;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE  Modifications to homes that increase energy efficiency and improve indoor temperatures may reduce the health impacts of extreme temperatures and financial stress. We will characterize and monetize the health impacts of low-cost and higher-cost weatherization measures, which may improve the health of older adults through improvements to sleep, cognitive function, and financial worry as well as community-wide reductions in air pollution exposure. Weatherization interventions may allow older adults to both mitigate and adapt to extreme weather.

PI_NAMEs: GRONLUND, CARINA  (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: actigraphy;Address;Air;Air Pollution;ambient air pollution;American;Asthma;Categories;Cities;Climate;Cognition;cognitive function;Cold Climate;Communities;cost;Cost Savings;Cost utility;Costs and Benefits;disparity reduction;Education;Emergency department visit;Energy consumption;energy efficiency;Enrollment;Evaluation;Expenditure;Exposure to;extreme temperature;extreme weather;Financial Hardship;Fire - disasters;Food;Funding;Generations;Health;Health Benefit;health disparity;Health Expenditures;High temperature of physical object;Home;Home environment;Hour;Household;Housing;Humidity;improved;Intervention;intervention effect;intervention program;Laboratories;Longitudinal Studies;Low income;Measurement;Measures;Medical;Medicine;Modification;Monitor;Morbidity - disease rate;mortality;Neuropsychology;novel;nutrition;Occupational;older adult;Outcome;Participant;Persons;Policies;Poverty;Power Plants;Probability;Program Evaluation;programs;Psychosocial Stress;Reporting;Research;respiratory health;response;Risk;Savings;seal;Shapes;Sleep;sleep quality;supported housing;Surveys;Temperature;Weather

PROJECT_TITLE: Assessing the Neuropsychological Benefits of Weatherization Programs


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Disability Research;Machine Learning and Artificial Intelligence;Osteoarthritis;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Osteoarthritis of the knee is a leading cause of disability in elderly people, and no curative treatments exist. Early detection of osteoarthritis might help delay or prevent the onset of disability later in life. We propose a rapid and robust approach for the quantitative multi-compartment assessment of knee cartilage without using either exogenous contrast agent or hardware modifications as an early screening tool for osteoarthritis.

PI_NAMEs: REGATTE, RAVINDER ;WUST ZIBETTI, MARCELO VICTOR (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Algorithms;articular cartilage;Binding;Biochemical;Biological Models;Cartilage;cartilage degradation;Chronic disability;Clinical;Clinical Protocols;Collagen;Collagen Fiber;Contrast Media;curative treatments;Data;Data Set;Degenerative polyarthritis;design;Detection;Diagnostic;disability;Discrimination;Early Diagnosis;early screening;efficacy evaluation;Elderly;Evaluation;Extracellular Matrix;Extracellular Matrix Degradation;Future;Goals;healing;Heterogeneity;Human;human data;Hydration status;Image;Imaging Techniques;improved;in vivo;Knee;Knee joint;Knee Osteoarthritis;Learning;learning algorithm;Life;Machine Learning;macromolecule;Magnetic Resonance Imaging;Maps;Meniscus structure of joint;Meta-Analysis;Methods;Modeling;Modification;Morphology;Musculoskeletal;Non-Invasive Detection;Pathologic Processes;Patients;Pattern;Performance;Persons;Population;prevent;Process;Proteoglycan;Protocols documentation;reconstruction;Relaxation;repaired;Research Personnel;Resolution;Rotation;Sampling;Scanning;Screening procedure;Slice;Structure;T2 weighted imaging;Techniques;Therapeutic Agents;Thick;Thinness;Time;Tissue Engineering;Tissues;tool;Translating;Validation;Visualization;Water;water environment

PROJECT_TITLE: Data-Driven Learning Framework for Fast Quantitative Knee Joint Mapping

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Our CTSA K12 Program at the University of Colorado proposes a creative and innovative institutional research career development program to prepare an outstanding heterogeneous pool of promising junior faculty scholars in clinical and translational science (CTS) committed to independent research careers that will support their timely transition to more advanced support mechanisms. The program will provide protected time to junior faculty scholars across disciplines for foundational training under the guidance of a mentoring dyad with expertise in CTS, supported by coaching and advising from K12 program directors. The program extends traditional clinical and translational research training by ensuring that elements of mentoring training, team management and leadership, advanced communications and dissemination strategies, and building effective partnerships across the translational ecosystem are addressed to ensure successful CTS careers of its scholars.

PI_NAMEs: BURNHAM, ELLEN L (contact)

PROGRAM_OFFICER_NAME: CURE, PABLO

PROJECT_TERMS: Academic skills;Address;Appointment;career;career development;Characteristics;Clinical Research;Clinical Sciences;clinical translation;Collaborations;Colorado;Communication;Competence;Development;Development Plans;Discipline;Disease;Ecosystem;Education;Ensure;Environment;Equity;Evaluation;experience;Extramural Activities;Faculty;faculty mentor;Funding;Growth;improved;Individual;innovation;Institution;interest;K-12 Faculty;Knowledge;Leadership;member;Mentored Clinical Scientist Development Program;Mentors;Neighborhoods;Positioning Attribute;Process;programs;recruit;Research;Scientist;Self Efficacy;skill acquisition;skills;System;Thinking;Training;Training Programs;Translational Research;translational scientist;Uncertainty;Universities;Workforce Development;Writing

PROJECT_TITLE: CTSA K12 Program at University of Colorado Denver


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Radiation Oncology

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative A major impediment in translating animal radiation studies to human patients is the disparity in radiation techniques. Existing methods cannot create human like conformal radiation dose on mice with necessary accuracy and efficiency. To better mimic human treatment without prohibitively complicated and slow procedures, we propose to develop a high throughput image guided small animal conformal irradiation platform.

PI_NAMEs: SHENG, KE  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Acceleration;Address;Adoption;Affect;Algorithms;Anesthesia procedures;Animals;automated segmentation;Automation;biological research;Calibration;Characteristics;Clinical;Clinical Trials;Collimator;Complex;Computer software;Conformal Radiotherapy;deep learning;deep neural network;design;Development;Devices;Disparity;Dose;dosimetry;Engineering;Environment;experimental study;Future;Grant;Human;Image;image guided;Immunologics;improved;in silico;Individual;innovation;Intensity-Modulated Radiotherapy;Intervention;irradiation;Knowledge;Manuals;Mathematics;Methods;miniaturize;Mus;novel;Organ;parallelization;Patients;Performance;pre-clinical;pre-clinical research;Predisposition;Procedures;process optimization;Radiation;Radiation Dose Unit;Radiation therapy;Radio;Radiobiology;Research;Resolution;Resources;Risk;Robotics;Roentgen Rays;safety testing;success;System;Techniques;Technology;Testing;Time;timeline;tool;Toxic effect;Training;Translating;Translations;treatment planning;trend;tumor;Uncertainty;United States National Institutes of Health;user-friendly;Validation

PROJECT_TITLE: Development of A High Throughput Image-Guided IMRT System forPreclinical Research

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSCIENCES

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE Using an innovative and timely approach integrating multi-omic multi-regions data from 750 human brains with a range of cognition and brain pathologies, we will identify proteins, isoforms, proteolytic fragments, and PTMs associated with β-amyloid, PHFtau tangles, α-synuclein, hippocampal sclerosis, and TDP-43, and other AD- related pathologic and clinical traits. These proteins will be potential high value therapeutic targets which will be passed to the Accelerated Medicines Partnership-AD (AMP-AD) consortium and shared with the wider aging and dementia research community for further study. The identification of these proteins will have a high and sustained impact on the field.

PI_NAMEs: BENNETT, DAVID ALAN (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Acceleration;Aging;alpha synuclein;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;Anterior;Automobile Driving;Biological;Brain;Brain Pathology;Brain region;cell type;Cells;Clinical;Code;Cognition;Communities;Computational Biology;Coupling;Data;Dementia;DNA Methylation;entorhinal cortex;Environment;epigenomics;Event;Funding;Genes;Genome;genome sequencing;genome-wide;Genomics;Goals;Grant;hippocampal sclerosis;Hippocampus;Histone Acetylation;Human;Impaired cognition;Individual;innovation;Investigation;Lewy Bodies;Link;link protein;Mass Spectrum Analysis;Medical;Medicine;Memory;MicroRNAs;Molecular;Motor Cortex;Multiomic Data;multiple omics;Neocortex;neocortical;Neurobiology;Neurodegenerative Disorders;Neurofibrillary Tangles;neuropathology;new therapeutic target;novel;Participant;Pathologic;Pathology;Pathway interactions;Persons;Post-Translational Protein Processing;Prefrontal Cortex;Protein Isoforms;protein TDP-43;Proteins;Proteomics;Psychological Factors;Publishing;religious order study;Research;Risk Factors;RNA;RNA Splicing;single-cell RNA sequencing;System;tau Proteins;Temporal Lobe;therapeutic target;Tissues;trait;transcriptome sequencing;transcriptomics;translational research program;virtual;whole genome

PROJECT_TITLE: Risk Factors, Pathology, and Clinical Expressions of AD

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Disability Research;Infectious Diseases;Nutrition;Physical Activity;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Tiredness, weakness, and disability occur more frequently in older people living with HIV than in  non-infected people of a similar age. The reasons are not known. These studies will investigate  whether the ability of muscles to metabolize nutrients to generate energy is impaired and  contributes to the increased weakness and physical decline in older people living with HIV.

PI_NAMEs: WEISS, ROBERT G (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Address;Adult;Age;Aging;Attenuated;Bioenergetics;Biological Markers;Biopsy;Body Composition;Body mass index;Clinical Research;cohort;Data;design;disability;Dual-Energy X-Ray Absorptiometry;effective therapy;Elderly;Energy Metabolism;Exercise;exercise intolerance;Exercise Test;Exercise Tolerance;experience;Fatigue;Fatty acid glycerol esters;Frail Elderly;frailty;functional decline;Functional disorder;Future;Gait;Gait speed;Gender;General Population;HIV;HIV Infections;Human;human old age (65+);immune activation;Impairment;in vivo;Individual;Inflammation;inorganic phosphate;insight;Intervention;Life;Lipids;Lower Extremity;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;men;Metabolic;metabolic myopathies;Metabolism;middle age;Mitochondria;Mitochondrial DNA;Mobility disability;Morbidity - disease rate;mortality;Muscle;Muscle Mitochondria;Muscular Dystrophies;Myopathy;novel;Nutrient;older men;Older Population;older women;patient population;Performance;Persons;Phenotype;Population;pre-clinical;premature;Preparation;Quality of life;Race;Rest;Role;sex;skeletal;Skeletal Muscle;Stress;Syndrome;Testing;United States National Institutes of Health;Walking;Woman

PROJECT_TITLE: Mitochondrial energetics, exercise intolerance and fatigability in older people with HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Project Narrative Underrepresented minority groups are disproportionately impacted by substance use disorder, and Hispanics (the largest racial/ethnic minority population in the United States) are overrepresented in the total number of individuals affected by substance use disorder. Hispanics are also underrepresented in biomedical, socio- behavioral, and implementation science disciplines, and the lack of Hispanic representation in these disciplines contributes to health disparities as they pertain to substance use and related comorbidities. The annual National Hispanic Science Network (NHSN) conference is the premier venue for transdisciplinary, interdisciplinary, and interprofessional scientific discussions on strategies to minimize the impact of substance use disorder on health disparities in Hispanics and other underrepresented minority groups as well as for promoting and strengthening Hispanic interdisciplinary social professional networks to address the disparities.

PI_NAMEs: MOLINA, PATRICIA E. (contact)

PROGRAM_OFFICER_NAME: REICHEL, CARMELA MARIE

PROJECT_TERMS: Address;Affect;African American;Area;Asian Americans;Basic Science;Behavioral;Behavioral Sciences;Biological;career;career networking;Clinical Sciences;Communities;Community Practice;comorbidity;Cultural Backgrounds;cultural competence;Dedications;Development;Discipline;Disparity;Drug abuse;Environmental Health;Environmental Risk Factor;Epidemiology;Epigenetic Process;ethnic minority population;Ethnic Origin;falls;Fertilization;Fostering;Funding;Future;gender diverse;Generations;Genetic;Genomics;Geographic Locations;Goals;Grant;Health;health disparity;health equity;Health Policy;Hispanic;hispanic community;Hispanic Graduate Student;Hispanic Populations;implementation science;improved;Individual;innovation;Institution;interdisciplinary collaboration;interest;Intervention;meetings;member;Mentors;Minority Groups;minority health;Mission;Molecular;multidisciplinary;National Institute of Drug Abuse;Native Americans;Neurobiology;Neurosciences;peer support;Policies;Population;Psychology;racial minority population;recruit;Research;Research Personnel;Research Priority;role model;Science;Scientist;Senior Scientist;social;Social Behavior;social factors;sociocultural determinant;Sociology;substance use;Substance Use Disorder;Support Groups;symposium;Toxicology;Translational Research;Underrepresented Minority;United States

PROJECT_TITLE: National Hispanic Science Network on Drug Abuse (NHSN) Annual Conference


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative: This proposal uses advanced sequencing technologies and molecular perturbations to investigate how genes are regulated in human cells. The data generated by these approaches will be analyzed to reveal how regions of regulatory DNA are spatially and functionally organized at both the level of individual nucleotides and their distribution across the genome. This information will help interpret how mutations in human DNA may lead to developmental defects or increased susceptibility to disease.

PI_NAMEs: BENNER, CHRISTOPHER W (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 3-Dimensional;Affect;Affinity;base;Binding;Binding Sites;Biological;Cells;Chromatin;chromatin modification;Data;Defect;Development;Disease;Distal;DNA;DNA Binding;epigenetic marker;epigenetic profiling;Frequencies;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Enhancer Element;Genetic Transcription;genetic variant;Genetic Variation;Genome;genomic locus;Genomics;Human;human DNA;Individual;insight;Laboratories;Location;Measurement;Modeling;Molecular;Mutation;novel;Nucleic Acid Regulatory Sequences;Nucleotides;Play;Positioning Attribute;Predisposition;promoter;recruit;Regulatory Element;Reporter;Research;RNA Polymerase II;Role;Signal Transduction;Specific qualifier value;Stimulus;Structure;Technology;transcription factor;Transcription Initiation;Transcription Initiation Site;Work

PROJECT_TITLE: Multiscale genomic decryption of regulatory DNA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-C (55)]


PHR: Hospital In Home [HIH] is a model of care that delivers patient-centered, acute-level hospital care at home which has demonstrated safety, effectiveness and patient satisfaction beyond those observed in hospitals. Currently there are [twelve] HIH sites across the VA that are sustained by their stations; understanding how to weave the implementation experiences of these programs successfully is the overarching aim of this project. The project will evaluate the existing sites and develop implementation tools and strategies based on their experience. A readiness for implementation survey will be used to identify ten additional sites for implementation. It will then “dry run” the processes of implementation in these sites, further identifying implementation strategies and resulting in blueprints for implementation.

PI_NAMEs: HUNG, WILLIAM W.,MPH, MD;INTRATOR, ORNA K. (contact);SULLIVAN, JENNIFER L

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Admission activity;Adoption;Beds;Benchmarking;Caring;Catalogs;Client satisfaction;Communities;Complex;Contracts;Cost Savings;COVID-19 pandemic;design;Development;Disease;Dryness;dynamic system;Effectiveness;effectiveness/implementation trial;Evaluation;Evaluation Reports;Event;experience;experimental study;Feedback;Focus Groups;Future;Geriatrics;Growth;guidebooks;Health Services Accessibility;Home;hospital care;Hospital safety;Hospitals;Hybrids;implementation barriers;implementation evaluation;implementation framework;Implementation readiness;implementation science;implementation strategy;implementation tool;Incentives;informant;innovation;Inpatients;interest;Intervention;Interview;Knowledge;knowledge curation;Learning;Logic;Long-Term Care;Maps;Marketing;Mentors;Methodology;Methods;Mission;Modeling;novel;Parents;patient oriented;Patient-Focused Outcomes;preference;Probability;Process;programs;Quality of Care;Quantitative Evaluations;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Reporting;Resources;Running;Safety;Science;Series;simulation;Site;Standardization;stem;Surveys;System;Techniques;tool;United States Department of Veterans Affairs;Variant;Veterans;Work

PROJECT_TITLE: Hospital In Home: Evaluating Need and Readiness for Implementation (HENRI)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Diagnostic pitfalls and clinicopathological heterogeneity limit the certainty of prognostication for patients with the behavioral variant of frontotemporal dementia (bvFTD). The focus of this project is to identify patterns of clinical features in patients at their first visit that increase certainty in the clinical diagnosis, prediction of the underlying pathological diagnosis, and precision of prognosis. This research will provide guidance to clinicians, increase the accuracy of information provided to patients and families, lead to refinement of diagnostic criteria, and facilitate enrollment in clinical trials.

PI_NAMEs: PERRY, DAVID C (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: accurate diagnosis;Activities of Daily Living;Affective Symptoms;Age of Onset;Alzheimer's Disease;Atrophic;Autopsy;Behavioral;Behavioral Symptoms;behavioral variant frontotemporal dementia;Biological Markers;Caregivers;Caring;Characteristics;Classification;classification algorithm;Clinical;clinical care;clinical diagnosis;clinical heterogeneity;clinical prognosis;Clinical Trials;Cognition;Cognitive;cognitive testing;cohort;Data;Dementia;Development;Diagnosis;Diagnostic;diagnostic criteria;Disabling;Disease;Disinhibition;emotional functioning;Enrollment;Evaluation;Family;follow-up;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;functional decline;Gene Expression;Genetic;genetic testing;Goals;Heterogeneity;Image;Immune;Impaired cognition;improved;Individual;individual patient;Inflammatory;International;Lead;Light;Mental disorders;Microtubules;molecular subtypes;Molecular Target;Motor;Motor Neuron Disease;Nerve Degeneration;Neurodegenerative Disorders;neurofilament;neuroimaging;Neurologic;Neurologic Examination;neuropathology;Neuropsychology;Newly Diagnosed;Observation in research;Observational Study;Parkinsonian Disorders;participant enrollment;Pathologic;Patients;Pattern;Personality;Phenocopy;Predictive Factor;predictive tools;preservation;Process;Prognosis;prognostic;prognostication;Program Research Project Grants;psychiatric symptom;Research;Serum Markers;Services;Severities;Social Functioning;Symptoms;Syndrome;tau Proteins;Time;Tissue-Specific Gene Expression;trial enrollment;Uncertainty;Visit;Weight;white matter;Work

PROJECT_TITLE: Diagnostic and prognostic certainty in behavioral variant frontotemporal dementia

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative This project is important because stretching exercise may promote health and prevent complications of pregnancy when most pregnant women become sedentary. Stretching exercise may be practical for obese pregnant women, many of whom happen to be minority and underserved. Stretching exercise is known to have high acceptance, better adherence, no known untoward side effects, and promising preliminary evidence of effectiveness.

PI_NAMEs: YEO, SEONAE  (contact)

PROGRAM_OFFICER_NAME: LONG, SYLVIA ELISABETH

PROJECT_TERMS: 2 arm randomized control trial;37 weeks gestation;Accelerometer;Adherence;Admission activity;Age;American College of Obstetricians and Gynecologists;Antioxidants;Anxiety;arm;arterial stiffness;Behavior Therapy;Behavioral;Biological Markers;Birth;Blood Pressure;blood pressure reduction;Body mass index;Cardiac;Cardiovascular Diseases;cardiovascular effects;cardiovascular health;Cardiovascular Physiology;Cardiovascular Pregnancy Complications;cardiovascular risk factor;Cardiovascular system;Cesarean section;Cessation of life;Child Mortality;cost efficient;Diastolic blood pressure;Effectiveness;efficacy testing;electric impedance;Emergency Situation;Equilibrium;Ethnic Origin;evidence base;Exercise;exercise intervention;fetal;Gestational Age;Gestational Diabetes;Goals;Health;Health Promotion;heart rate variability;high risk population;improved;Incidence;interest;Late pregnancy;Life;life span;Light;light intensity;Link;Long-Term Effects;Low Birth Weight Infant;Maternal Mortality;maternal risk;Measures;Minority;Minority Groups;Moderate Exercise;Morbidity - disease rate;Muscle;Neonatal;novel;Obesity;obesity management;Outcome;Overweight;Oxidative Stress;Physical activity;Pilot Projects;Population;Positioning Attribute;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy hypertension;Pregnancy Outcome;Pregnant Women;Premature Birth;prevent;primary outcome;Production;protective effect;Protocols documentation;Race;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reporting;Research Personnel;Risk;Risk Reduction;Sampling;secondary outcome;sedentary;side effect;Skeletal Muscle;Smoking;Strenuous Exercise;Stretching;success;Superoxide Dismutase;Testing;Third Pregnancy Trimester;Transferrin;treatment as usual;Underserved Population;Up-Regulation;vigorous intensity;Walking;Woman

PROJECT_TITLE: Promoting stretching exercise to reduce cardiovascular health risk in late pregnant women with obesity

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_DEPT: GENETICS

PHR: Our study will assess comparative effectiveness and cost-effectiveness of two tuberculosis (TB) active case finding strategies (ACF) among recently treated TB patients to detect recurrent TB. The strategies are household ACF (HHACF) and ACF by periodic telephonic interviews (TACF) followed by HH visits for HHs reporting any symptoms telephonically. We are working in close collaboration with India's national TB program and will assess acceptability and feasibility, and determine resources needed for scale-up and maintenance of the more successful strategy.

PI_NAMEs: GOLUB, JONATHAN E. (contact);MAVE, VIDYA

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: acceptability and feasibility;Aftercare;Alcohol consumption;arm;case finding;Clinic;Collaborations;Collection;Communication;Communities;comparative effectiveness;compare effectiveness;cost;cost effectiveness;cost estimate;Data;Detection;Diabetes Mellitus;Diagnosis;Diagnostic;disability-adjusted life years;Disease;Ensure;Epidemic;experience;follow-up;Future;Goals;Guidelines;Health Personnel;Health Services;Heterogeneity;high risk;high risk population;Home;Hospitals;Household;Impairment;implementation facilitators;implementation process;improved;Incidence;incremental cost;indexing;India;interest;Intervention;intervention cost;Knowledge;Leadership;Maintenance;markov model;Measures;member;Modeling;Morbidity - disease rate;mortality;multidisciplinary;outreach;patient screening;Patients;Periodicals;Persons;Population;programs;Public Sector;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recurrence;Recurrent disease;Reporting;Research Infrastructure;Resources;respiratory;Risk;scale up;screening;Smoke;Sputum;Strategic Planning;Symptoms;System;Telephone;telephone based;Telephone Interviews;Time;transmission process;Tuberculosis;tuberculosis treatment;Visit;Work;World Health Organization

PROJECT_TITLE: TB Aftermath

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA AGRICULTURAL AND MECHANICAL UNIV

ORG_STATE: FL

PHR: Project Narrative Chronic exposure to elevated levels of manganese (Mn) causes dopaminergic toxicity including a reduction in tyrosine hydroxylase levels and dopaminergic neuronal function, with ensuing injury to the nigrostriatal pathway, leading to cause Parkinson's disease (PD)-like symptoms, referred to as manganism. Tamoxifen, a selective estrogen receptor modulator (SERM), exerted protection against Mn-induced dopaminergic neurotoxicity. The mechanism by which TX attenuates Mn toxicity is not well understood, but our preliminary findings show that a transcription factor RE1-silencing transcription factor (REST) is critically involved in TX-induced neuroprotection against Mn toxicity. Delineating the molecular mechanism by which REST affords neuroprotection will not only impart novel insight into mechanisms of Mn-induced neurotoxicity, but also identify novel targets for strategies to combat manganism and diseases related to dopaminergic neuronal dysfunction, such as PD. Therefore, in this proposal, we will study the mechanism of REST-induced neuroprotection against Mn toxicity and role of REST in TX-induced protective effects in Mn neurotoxicity.

PI_NAMEs: LEE, EUN SOOK YU (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Adult;Adverse effects;aged;Alzheimer's disease patient;Animal Disease Models;Antioxidants;Apoptosis;Apoptotic;Attenuated;BCL2 gene;beta catenin;Binding;Brain;Breast Cancer Patient;catalase;Cells;Chronic;Clinical Research;Cognitive deficits;combat;Data;dementia risk;Development;Disease;Dopamine;dopaminergic neuron;Enzymes;Epigenetic Process;ESR1 gene;Estradiol;estrogenic;Experimental Models;Exposure to;Female;female sex hormone;Foundations;Functional disorder;Gene Expression Profile;Genes;Genetic Transcription;Genomics;GPER gene;Human;In Vitro;in vivo;Inflammation;Injury;insight;Learning;life span;male;Manganese;Manganism;Mediating;Mediator;Memory;Molecular;Molecular Target;Mus;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;Neuronal Dysfunction;Neuronal Injury;Neurons;neuroprotection;neurotoxicity;Neurotoxicity Attenuation;nigrostriatal pathway;non-genomic;novel;Outcome Study;Ovariectomy;overexpression;Oxidative Stress;Oxidative Stress Induction;Parkinson Disease;Pathologic;Pathway interactions;Peripheral;pharmacologic;Phenotype;Play;promoter;protective effect;RE1-silencing transcription factor;recruit;Repression;restoration;Risk Factors;Risk Reduction;Role;Selective Estrogen Receptor Modulators;Signal Transduction;Symptoms;Tamoxifen;Technology;Testing;Therapeutic;Toxic effect;transcription factor;Tyrosine 3-Monooxygenase;Up-Regulation;vector;WNT Signaling Pathway;YY1 Transcription Factor

PROJECT_TITLE: Mechanisms associated with neuroprotection from Mn-induced neurotoxicity.


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative This project addresses key challenges to the design of clinical trials to prevent the onset of Huntington's disease (HD). The project will provide necessary psychometric data for a measure of mutant huntingtin protein in the cerebral spinal fluid to address questions of central importance to the success of this measure for premanifest clinical trials such as: (1) How reliable the measure is in the same person when repeated over time; (2) how reliable the measure is in the same person when analyzed by two different labs/sites; (3) how well the measure reflects disease symptoms; (4) how well the measure predicts meaningful disease outcomes; (5) how well the measure tracks disease progression or severity; and (6) how many research subjects are required to test that an intervention is delaying/slowing the onset of HD? Answers to these questions will better position the field to more effectively test new interventions to prevent HD such as gene therapies and new drugs.

PI_NAMEs: PAULSEN, JANE S (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Activities of Daily Living;Address;Adenine;Age;autosome;Behavioral;Benchmarking;Biological;Biological Assay;Biological Markers;blind;Brain;burden of illness;CAG repeat;candidate marker;Cell Death;Cell Physiology;Cerebrospinal Fluid;Characteristics;Clinic;Clinical;clinical outcome measures;Clinical Trials;Clinical Trials Design;Cognitive;Cost efficiency;cost efficient;cytokine;Cytosine;Data;design;Detection;Diagnosis;Disease;Disease Outcome;disease phenotype;Disease Progression;Event;Exons;functional disability;Future;gene therapy;Genes;Genetic;Goals;Guanine;Huntington Disease;Huntington gene;Individual;Inflammatory;inflammatory marker;Interleukin-6;Intervention;Investigation;Lead;Length;Measures;Motor;mutant;Natural History;Neurodegenerative Disorders;neuron loss;Noise;novel therapeutics;Nucleotides;Onset of illness;Participant;Pathway interactions;Patient Outcomes Assessments;Persons;Phenotype;Positioning Attribute;predictive test;prevent;Preventive Clinical Trial;Production;prognostic;prognostic model;Property;Proteins;Psychometrics;Publishing;reduce symptoms;Research;research study;Research Subjects;Resources;Safety;Sample Size;Severities;Severity of illness;Signal Transduction;Signs and Symptoms;Site;success;Symptoms;tau Proteins;Technology;Testing;therapeutic target;Time;Toxic effect;volunteer

PROJECT_TITLE: Preparing for preventive clinical trials in Huntington's disease


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: WIEN

ORG_COUNTRY: AUSTRIA

ORG_FIPS: AU

ORG_NAME: VETERINARMEDIZINISCHE UNIVERSITAT WIEN

PHR: Project Narrative Chlamydia trachomatis is the most prevalent bacterial sexually transmitted pathogen worldwide with an urgent need for a protective vaccine; it is also closely related to the pig pathogen C. suis and both induce a cross- reactive immune response. The proposed research uses a novel C. suis pre-exposed outbred pig model to develop a C. trachomatis vaccine candidate; and it will provide an in-depth analysis of the protective immune response. This research will have three major benefits, it will: i) develop a novel C. trachomatis vaccine candidate, ii) further establish a valuable genetically diverse animal model for C. trachomatis research, vaccine development, and testing; and iii) greatly improve our understanding of a protective immune response.

PI_NAMEs: KAESER, TOBIAS E (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Adjuvant;Animal Model;Animals;Antibiotic Therapy;Antibiotics;Antigens;Azithromycin;Bacterial Sexually Transmitted Diseases;Biological Assay;Biomedical Research;Blood;CD4 Positive T Lymphocytes;CD8B1 gene;cell mediated immune response;Cells;Chlamydia;Chlamydia trachomatis;Clinical;Clinical Trials;Color;Cross Reactions;cross reactivity;Data;Development;Disease;Ectopic Pregnancy;efficacy testing;Enzyme-Linked Immunosorbent Assay;exposed human population;Exposure to;Family suidae;Flow Cytometry;Generations;Genitalia;Goals;Health;Health Care Costs;HIV Infections;Homing;Hormonal;Human;Immune;Immune response;Immune system;Immunity;Immunofluorescence Immunologic;immunogenic;immunogenicity;Immunoglobulin A;Immunohistochemistry;improved;In Vitro;Inbred Mouse;Infection;Infertility;Interferon Type II;Intramuscular;Intranasal Administration;Literature;major outer membrane protein;Memory;Miniature Swine;Modeling;mouse model;Mucous Membrane;Mus;nanoemulsion;Neutralizing antibody assay;novel;novel vaccines;particle;pathogen;Patients;Pelvic Inflammatory Disease;Peptide antibodies;Peptides;Phase;Phase III Clinical Trials;Physiology;Population;porcine model;pre-clinical;Predisposition;Prevalence;Proteins;Regimen;Reproducibility;reproductive;reproductive tract;Research;Research Personnel;Resolution;response;Risk;Sexual Transmission;single-cell RNA sequencing;Sorting;standard of care;Streptococcus suis;Subunit Vaccines;success;T cell infiltration;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Target Populations;Technology;Testing;Tissues;Vaccination;vaccination outcome;vaccination strategy;vaccine access;vaccine candidate;vaccine development;vaccine efficacy;vaccine evaluation;vaccine formulation;vaccine immunogenicity;Vaccine Research;vaccine trial;Vaccines;γδ T cells

PROJECT_TITLE: Development of a Chlamydia trachomatis Vaccine in an Outbred Pre-exposed Swine Animal Model

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: Multimorbidity is common among Veterans and results in poor health-related quality of life (HRQoL) and contributes to high health care utilization and costs. Patients with multimorbidity need to engage in self- management for many of their chronic conditions. Patients with multimorbidity experience significant barriers to self-management and, due to limitations of traditional primary care visits, they need supplementary support to optimally engage in self-management. Peer support delivered by trained Veteran peer health coaches is well suited to fill this need. Limited research has evaluated the effectiveness of peer support in the context of multimorbidity. The proposed study seeks to evaluate whether a telehealth-delivered peer health coaching intervention improves HRQoL compared to usual VA care among high-risk patients with multimorbidity. It also aims to understand barriers and facilitators to implementing the program in VA if it is effective. This research may enhance VA’s ability to provide services to Veterans with multimorbidity and improve health outcomes.

PI_NAMEs: GRAY, KRISTEN E (contact);NELSON, KARIN M.

PROJECT_TERMS: Address;Adverse effects;behavioral outcome;Body System;care delivery;Caring;Chronic;Chronic Disease;Clinic Visits;Clinical;clinical care;Communities;Community Outreach;Complex;cost;Data;disability;Disease;Education;effectiveness evaluation;effectiveness-implementation RCT;effectiveness/implementation trial;electronic health data;Electronic Health Record;Eligibility Determination;Emergency Care;Emergency department visit;emotional symptom;Evaluation;experience;Face;frailty;Future;future implementation;Goals;Guidelines;Health;Health behavior;Health Care Costs;health care service utilization;health difference;health related quality of life;Health Services Accessibility;High Prevalence;high risk;hybrid type 1 trial;Hybrids;Impaired health;implementation facilitators;implementation intervention;improved;in-home care;Individual;innovation;Inpatients;Intervention;intervention cost;intervention participants;Intervention Trial;Life Style;Link;Measures;Mediating;Medical Care Team;meetings;Mental Health;Methodology;Modeling;mortality;multiple chronic conditions;Outcome;participant enrollment;patient oriented;Patient Self-Report;Patient-Centered Care;patient-clinician communication;Patient-Focused Outcomes;patient-level barriers;Patients;peer;peer support;Personal Satisfaction;Persons;physical conditioning;physical symptom;Polypharmacy;Population;Primary Care;primary care practice;primary care visit;primary outcome;Problem Solving;programs;Provider;psychological distress;psychosocial outcome;Qualitative Methods;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;remote delivery;Research;Resources;rural area;screening;secondary outcome;Self Efficacy;Self Management;Services;SF-12;shared decision making;Social support;Standardization;success;Technology;telehealth;Testing;Text Messaging;Time;Training;Translating;treatment as usual;Treatment Protocols;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;video visit;virtual;virtual healthcare;Visit;Work

PROJECT_TITLE: Telehealth-delivered peer support to improve quality of life among Veterans with multimorbidity

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Chronic Pain;Depression;Mental Health;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: RUSTON

ORG_NAME: LOUISIANA TECH UNIVERSITY

PHR: NARRATIVE Serotonin is involved in chronic pain in a receptor- and anatomical area-specific manner but the dynamics of serotonin across time and the effect of drug affecting serotonin are poorly understood. We will develop a novel implantable sensor to measure serotonin while simultaneously evaluating neural excitability over the development of neuropathic pain.

PI_NAMEs: CASTAGNOLA, ELISA  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Acids;Acute;Adhesions;Affect;Amygdaloid structure;Analgesics;Anatomy;anti-depressive agents;Area;Biological;Carbon;Carbon Nanotubes;Cell Nucleus;Cells;Chronic;chronic pain;chronic pain management;Chronic Phase;clinical efficacy;Cognition;Data;design;Detection;detection sensitivity;Development;Devices;Electric Stimulation;Electrodes;Electrophysiology (science);experimental study;extracellular;fabrication;Failure;Film;flexibility;Fluvoxamine;Genetic;Glass;Histologic;Hybrids;Hydrogen Peroxide;Implant;implantation;implanted sensor;improved;in vivo;Infusion procedures;Injury;interest;Learning;Link;Maintenance;Measurement;Measures;Mechanics;Memory;Metals;Microdialysis;Microelectrodes;Modeling;Monitor;Moods;Morphology;mouse model;multi-electrode arrays;Mus;nerve injury;Nervous System;neural;Neuropathy;novel;Pain;pain reduction;painful neuropathy;Pattern;Performance;Periodicity;Pharmaceutical Preparations;Phase;Polymers;prevent;Process;Property;Protocols documentation;receptor;response;Rewards;Rodent;Role;Running;Saline;Scanning;Selective Serotonin Reuptake Inhibitor;sensor;Serotonin;Serotonin Receptor 5-HT2C;Signal Transduction;Site;spared nerve;Surface;Technology;technology platform;technology validation;Testing;Therapeutic;Thinness;Time;Tissues;tool;Trace metal

PROJECT_TITLE: Probing the role of serotonin in neuropathic pain with flexible carbon microelectrode arrays

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Neurosciences;Physical Activity;Prevention;Rehabilitation;Women's Health Research

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Narrative: Up to 75% of breast cancer survivors suffer cognitive changes during treatment, and over 45% experience clinically significant cognitive decline pre- to post-treatment. Consistent evidence in older adults and growing evidence in breast cancer survivors suggests aerobic exercise training may reduce cancer-related cognitive decline. This study will compare changes in cognitive function and brain health in post-menopausal breast cancer survivors randomized to either: 1) a community-based aerobic exercise program; or 2) attentional control (health education).

PI_NAMEs: EHLERS, DIANE KRISTEN (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Acceleration;Address;Adjuvant Therapy;Adoption;Aerobic Exercise;Affect;Aftercare;Age-associated memory impairment;aged;Aging;Area;arm;attentional control;Brain;brain health;brain morphology;Brain region;brain volume;breast cancer diagnosis;Breast Cancer survivor;Cancer Survivorship;cancer therapy;cancer-related cognitive impairment;cardiorespiratory fitness;care delivery;Characteristics;chemotherapy;Clinical;Clinical effectiveness;Clinical Trials;clinically significant;Cognition;Cognitive;cognitive benefits;cognitive change;Cognitive deficits;cognitive enhancement;cognitive function;cognitive performance;cognitive task;Communities;comparison control;Consensus;Data;Dissemination and Implementation;Distress;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation design;Eligibility Determination;Evidence based program;executive function;Exercise;exercise intensity;exercise intervention;exercise program;Exercise Test;exercise training;Exhibits;experience;Fatigue;Fitness Centers;follow-up;Funding;Goals;Health;Health education;Hybrids;Impaired cognition;implementation outcomes;improved;Individual;information gathering;Institutionalization;Intervention;intervention delivery;Literature;Maintenance;Malignant Neoplasms;Measurement;Measures;Mediator;Mind;neuroimaging;Neuropsychology;normal aging;novel;Obesity;Observational Study;older adult;Outcome;Participant;Pathogenesis;Pathway interactions;Patient Self-Report;Performance;Physical activity;Population;post intervention;Postmenopause;primary outcome;Protocols documentation;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Research;Research Personnel;Research Support;Rest;Scientific Advances and Accomplishments;Scientist;secondary outcome;Short-Term Memory;Site;standard care;Stress;Structure;success;Survivors;Testing;Translations;Treatment Protocols;Treatment-Related Cancer;United States;United States National Institutes of Health;white matter;Woman;Work

PROJECT_TITLE: Enhancing cognitive function in breast cancer survivors through community-based aerobic exercise training

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Precision Medicine;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: LEXINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  To improve future treatment interventions for persons with opioid use disorders (POUDs) who are incarcerated, this study compares the multi-level factors influencing prison- and community-based initiation of medications for addiction treatment (MAT) and associated post-release outcomes under real-world conditions in rural Appalachian Kentucky, an economically-deprived region with limited service availability, and more resource-rich urban counties. This study will make significant contributions to public health and public safety by examining how rural-urban variation in personal social network characteristics support or impede the efforts of POUDs to access continuing treatment post-release, achieve stable recovery, and desist from crime during the vulnerable re-entry period.

PI_NAMEs: OSER, CARRIE BETH (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: addiction;Address;adverse outcome;Back;Caring;Characteristics;Communities;Continuity of Patient Care;County;Crime;Criminal Justice;Data;Distal;Drug Screening;Drug usage;economic disparity;Education;effective therapy;Elements;Eligibility Determination;Enrollment;Equipment and supply inventories;evidence base;experience;follow-up;Foundations;Future;geographic difference;Geographic Locations;Geography;Goals;Health;Health Services Accessibility;Healthcare;Imprisonment;improved;Individual;Injectable;interest;Intervention;Interview;Kentucky;Knowledge;Literature;Longitudinal cohort study;Measures;Mediating;Medicaid;medication for opioid use disorder;Mentors;Methods;Naltrexone;National Institute of Drug Abuse;offender;Opiate Addiction;opioid epidemic;opioid misuse;opioid use disorder;Outcome;Outpatients;Overdose;Persons;Pharmaceutical Preparations;Pilot Projects;Predictive Factor;primary outcome;Prisoner;Prisons;Process;process improvement;programs;prospective;Public Health;Qualifying;recidivism;Recovery;recruit;Relapse;relapse risk;Reproducibility;Research;Resources;response;Rural;Rural Appalachia;Rural Population;Safety;Sampling;Science;social;social influence;Social Network;social structure;Social Work;structural determinants;Structure;Substance abuse problem;Supervision;Support Groups;Surveys;System;Time;Treatment outcome;United States National Institutes of Health;uptake;Urban Population;Validation;Variant;willingness;Woman

PROJECT_TITLE: DAT18-08 Geographic variation in Opioid Addiction Treatment (GATE) study: Multi-Level Factors Influencing MAT Use, Other Treatment, & Adverse Outcomes among Re-entering Rural and Urban Prisoners