ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed public health research will yield high-quality evidence on the ability of an educational chatbot to equitably increase patient knowledge and uptake of prenatal genetic screening and diagnostic tests. If shown to be effective, this validated chatbot interface for genetic counseling will be easily adaptable and scalable to other languages and clinical settings.

PI_NAMEs: RUSSO, MELISSA LAUREN;TUULI, METHODIUS GAMUO (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Address;American College of Obstetricians and Gynecologists;Amniocentesis;Aneuploidy;Area;Attitude;Belief;Benefits and Risks;Birth Rate;care providers;Caring;carrier testing;cell free fetal DNA;chatbot;Child;Chorionic Villi Sampling;Clinic;Clinical;Complex;Computers;Counseling;Cystic Fibrosis;Data;Decision Making;Diagnosis;Diagnostic tests;digital health;digital tool;Down's Syndrome;E-learning;Education;Ensure;Equity;Face;Feedback;Genetic;Genetic Counseling;genetic counselor;genetic disorder diagnosis;Genetic Screening;genetic testing;Geographic Distribution;Goals;handheld mobile device;human centered design;Individual;innovation;Instruction;Knowledge;Language;Live Birth;maternal serum;minority patient;Modality;multidisciplinary;obstetric care;Outcome Study;Patients;person centered;Persons;post intervention;pregnant;Pregnant Women;prenatal;Prenatal care;Prenatal Genetic Counseling;prenatal testing;Provider;public health research;Race;racial disparity;randomized trial;Randomized, Controlled Trials;Recommendation;routine provider;screening;socioeconomic disparity;socioeconomics;Spanish/English;Spinal Muscular Atrophy;Standardization;success;Termination of pregnancy;Testing;testing uptake;Text;tool;United States;uptake;Visit;Work

PROJECT_TITLE: A Randomized Trial of Chatbot for Prenatal Genetic Counseling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: UNIVERSITY PARK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Neurons use the microtubule cytoskeleton as the tracks to transport building blocks to distant parts of the cell. For microtubules to be maintained over long distances in axons and dendrites, they need to be locally generated by nucleation. The goal of this project is to understand how nucleation is controlled in axons and dendrites, and whether surrounding cells regulate neuronal microtubule dynamics through nucleation.

PI_NAMEs: ROLLS, MELISSA  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Afferent Neurons;Axon;Biological Assay;Biological Models;Cell membrane;Cell Shape;Cells;Cellular biology;Cues;Cytoskeleton;Data;Dendrite Regeneration;Dendrites;Distant;Drosophila genus;Dynein ATPase;Endocytosis;Endosomes;Environment;Epithelial Cells;Epithelium;experimental study;Genetic;Goals;Individual;Injury;insight;Interphase Cell;Invertebrates;Kinesin;Ligands;Link;Mechanics;Membrane;Microtubules;Motor;mutant;Natural regeneration;Neuromuscular Junction;Neuronal Injury;neuronal survival;Neurons;neuroprotection;Outcome;Pathway interactions;Play;Positioning Attribute;presynaptic;Proteins;receptor;recruit;Regulation;response to injury;RNA Interference;Role;Signal Pathway;Signaling Protein;Site;Skin;Skin injury;Source;Structure;Synapses;System;Testing;tool;Translating;WNT Signaling Pathway;Work

PROJECT_TITLE: Mechanisms that control neuronal microtubule polarity

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Narrative Transition metal (TM) ions play myriad roles in biology and are present in >30% of structures in the PDB yet the accurate computational modeling of these ions is less evolved than for the “organic” framework of proteins. With the proposed advancement in modeling of TM ions important biological problems associated with TM ion homeostasis, metal center assembly, TM/drug interactions, dynamics of ligand association and product dissociation in metalloenzymes, attacking pathogens using nutritional immunity via TM sequestration near infection sites, etc. will now be able to be addressed. Through the development of robust computational models of TMs problems focused on TM ion biology will become as addressable as is currently possible for biological molecules lacking TM ions thereby opening up the ability to better explore TM ion-associated health issues.

PI_NAMEs: MERZ, KENNETH M. (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Acetates;Address;Affinity;aqueous;atomic interactions;Behavior;Binding;Binding Proteins;Binding Sites;Biochemical;Biological;biological systems;Biology;Biophysics;Bordetella bronchiseptica;Calorimetry;Cations;Charge;Collaborations;Communities;Computer Models;Computer software;computerized tools;Data;Databases;Deposition;Descriptor;design;Development;Dissection;Dissociation;Drug Interactions;experimental study;Free Energy;Goals;Health;Homeostasis;Hybrids;Imidazole;Infection;insight;Ion Transport;Ions;Letters;Ligands;Machine Learning;machine learning model;Metal Binding Site;Metal Ion Binding;metalloenzyme;Metalloproteins;Metals;Methodology;Methods;model building;Modeling;Molecular;molecular dynamics;molecular mechanics;Nature;next generation;novel;Nutritional Immunity;open source;pathogen;Play;preference;Proteins;Reporting;Role;simulation;Site;Structure;success;System;Thermodynamics;Titrations;tool;Transition Elements;Triplet Multiple Birth;Validation

PROJECT_TITLE: Modeling Transition Metal Ion Binding to Proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-H (02)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: PROJECT NARRATIVE The goal of this proposal is to understand the mechanisms that subserve the evolution of physical and cognitive fatigue through repeated exertion, and how fatigue inﬂuences decision-making in healthy individuals and those suffering from Major Depressive Disorder (MDD). The ﬁndings from this work may eventually reveal neurobehavioral markers and behavioral interventions to aid in treating physical and cognitive fatigue.

PI_NAMEs: CHIB, VIKRAM S (contact)

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: Affective Symptoms;Behavior;Behavior Therapy;Behavioral;Behavioral Mechanisms;Brain;Brain region;Characteristics;Classification;Clinical;Cognitive;comorbidity;computer framework;Computer Models;cost;Decision Making;Desire for food;Disease;Dissociation;dynamical evolution;Evolution;Exertion;exhaustion;Exhibits;experience;experimental study;Fatigue;Feeling;financial incentive;Functional Magnetic Resonance Imaging;Goals;Health;Human;Incentives;Individual;Individual Differences;innovation;Insula of Reil;Intervention;Knowledge;Life;Major Depressive Disorder;Mathematics;Mental disorders;Modeling;Monitor;Motivation;National Institute of Mental Health;Nervous System Disorder;neural;neurobehavioral;Neurobiology;neuromechanism;neuropsychiatric disorder;neuropsychiatry;novel;Participant;Patient Self-Report;Patients;Performance;Prefrontal Cortex;Prevalence;Process;Questionnaires;Recovery;Reporting;Research Domain Criteria;Rest;Rewards;Self Care;Signal Transduction;social engagement;Symptoms;Testing;Time;trait;willingness;Work

PROJECT_TITLE: Behavioral and Neural Representations of Subjective Effort Cost

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project narrative The number of genes that have been imputed to cause psychiatric disorders far outstrips the capacity to study their functions. Understanding the impact of genetic risk factors would be a major step toward improving the health and well-being of mankind. To accomplish this goal, researchers need the right tools: our research group will develop statistical and machine learning tools to interpret the findings of one of the most powerful tools developed in the past decade, namely CRISPR screens.

PI_NAMEs: ROEDER, KATHRYN M (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Acceleration;Accounting;Affect;analytical method;Animal Model;Atlases;autoencoder;Basic Science;Behavior;Brain;Calibration;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Complex;Computer software;Coupled;CRISPR screen;Data;data imputation;data integration;Data Set;deep learning;denoising;design;Development;differential expression;Ensure;Etiology;experience;experimental study;Gene Expression;gene function;Gene Proteins;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic Transcription;Genetic Variation;genome-wide;Genomics;Goals;Health;high dimensionality;high throughput screening;Human;improved;In Vitro;in vivo;Individual;innovation;Investigation;Joints;knockout animal;large scale data;Lead;Learning;Literature;machine learning method;Measurement;Mental disorders;Methods;model organism;Modeling;Molecular;mosaic;Multiomic Data;multiple omics;National Institute of Mental Health;neurobiological mechanism;Neurons;Nucleic Acid Regulatory Sequences;Outcome;Peptides;Personal Satisfaction;Play;Population;Positioning Attribute;Procedures;Proteins;Proteomics;Psychopathology;Quantitative Trait Loci;Research;Research Personnel;Resources;response;Risk;risk variant;Role;Sampling;semiparametric;single cell analysis;single cell technology;single-cell RNA sequencing;Source;spatiotemporal;statistical and machine learning;Statistical Methods;Strategic Planning;Structure;Supporting Cell;Testing;theories;Tissues;tool;transcriptome;transcriptomics;Untranslated RNA;user friendly software;Variant

PROJECT_TITLE: Methods for single-cell CRISPR screens and multiomic data: constructing powerful well-calibrated tests, circumventing unmeasured confounding, and accounting for denoising and imputation

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: HADLEY

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Alveolar macrophages are lung-resident myeloid cells that serve as innate immune sentinels for Mycobacterium tuberculosis (Mtb), a pathogen that claims more than 1.5 million lives each year. Following aerosol transmission, alveolar macrophages in the airway must recognize Mtb bacilli quickly and initiate the host immune response, yet it is not entirely known how innate sensing is regulated in these cells and what impact it has on disease outcomes. This project aims to characterize alveolar macrophage innate sensing in the context of Mtb infection by identifying defects in specific sensing pathways, testing candidate negative regulators, screening for novel regulators, and evaluating AM modulation by Type I and II Interferons in order to identify new therapeutic targets.

PI_NAMEs: ROTHCHILD, ALISSA CHEN (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Acceleration;adaptive immune response;Adoptive Transfer;Adult;Aerosols;Affect;Alveolar Macrophages;Antigen Presentation;Antigens;Bacille Calmette-Guerin vaccination;Bacillus;Bacteria;Bypass;Categories;Cause of Death;Cells;Chronic Obstructive Pulmonary Disease;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;COVID-19;CRISPR/Cas technology;Defect;Development;Diagnostic;Disease;Disease Outcome;draining lymph node;effector T cell;Epigenetic Process;Equilibrium;Event;Exposure to;Genes;global health;Growth;Homeostasis;Immune;Immune response;Impairment;in vitro Model;in vivo;Infection;Infectious Agent;Inflammatory;Inflammatory Response;Influenza;Interferon Type I;Interferon Type II;Interferon-beta;Interferons;Interleukin-10;Intervention;Knock-out;Knowledge;Lead;Libraries;Lung;lymph nodes;Macrophage;Measures;Modeling;Molecular;Mus;mycobacterial;Mycobacterium tuberculosis;Myeloid Cells;new therapeutic target;novel;novel therapeutics;novel vaccines;pathogen;Pathologic;Pathway interactions;Pattern;Phagocytes;Phenotype;recruit;Regulation;respiratory pathogen;response;restraint;Role;screening;Sentinel;Shapes;Signal Pathway;Signal Transduction;Site;surfactant;System;T-Cell Activation;T-Lymphocyte;targeted delivery;targeted treatment;Testing;Therapeutic;therapeutic target;Tissues;trafficking;Training;transmission process;Tuberculosis;tuberculosis treatment;Up-Regulation;Vaccines

PROJECT_TITLE: Innate sensing of M. tuberculosis by alveolar macrophages

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Networking and Information Technology R&D (NITRD)

ORG_CITY: DURHAM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE STATEMENT This proposal aims to address major limitations in the traditional MRI scanner architecture by developing a stand-alone, platform-independent high-channel-count wireless integrated RF/shim coil array with on-board receiver chain and cloud-based data processing workflow that will enable wireless MRI and localized B0 shimming with a single coil array. This innovative wireless MRI scanner architecture will drastically reduce the system complexity, footprint, and cost, while improving the freedom of positioning, patient comfort, safety, SNR, spatial fidelity, and image quality for many MRI applications, which is expected to improve the diagnosis and treatment of a wide range of diseases throughout the human body.

PI_NAMEs: DARNELL, DEAN ;SONG, ALLEN W;TRUONG, TRONG-KHA  (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Address;Amplifiers;Architecture;Brain;Brain imaging;Burn injury;Cervical spine;Clinical;clinical application;cloud based;computerized data processing;cost;Data;data streams;design;Development;Devices;Diagnosis;diagnostic accuracy;Disease;experimental study;flexibility;Freedom;Future;Goals;Head and neck structure;Human;Human body;Image;Imaging Techniques;improved;in vivo;innovation;magnetic field;Magnetic Resonance Imaging;Manufacturer;Methods;miniaturize;Modernization;Morphologic artifacts;Motion;multiple input multiple output;Noise;novel;Outcome;Patients;Performance;Peripheral;Physiologic Monitoring;platform-independent;Positioning Attribute;Protocols documentation;public health relevance;radio frequency;reconstruction;Safety;safety testing;Signal Transduction;System;Technology;Time;transmission process;Validation;virtual;wireless;wireless data transmission;wireless electronic;Wireless Technology

PROJECT_TITLE: Wireless MRI with a stand-alone, platform-independent wireless integrated radio-frequency/shim coil array and cloud-based data processing workflow

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: IOWA CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE A decline in microbial diversity caused by certain antibiotics increases the risk of heart failure, suggesting that the gut harbors cardioprotective microbes, but microbial reshaping that improves cardiac resistance to hypertrophic stress is unknown. This proposal will test the hypothesis that vancomycin-induced reshaping of the gut microbiome enriches Lactobacillus sp. that promotes tryptophan's metabolism to tryptamine, leading to upregulation of cardiac microRNA-204-5p that inhibits myocardial hypertrophy and dysfunction. The completion of this project is expected to identify specific microbes (e.g., Lactobacillus murinus), metabolites (e.g., tryptamine), and signaling intermediaries (e.g., miR-204) that mediate the cardioprotective effects of vancomycin, and these findings will be relevant for mitigating heart failure.

PI_NAMEs: VIKRAM, AJIT  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Antibiotics;Aortic Valve Stenosis;APLN gene;Bacteria;bacterial metabolism;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Chronic;Circulation;Cues;Data;Development;Echocardiography;fecal microbiota;fecal transplantation;Feces;Fibrosis;Functional disorder;Glycopeptide Antibiotics;Glycopeptides;gut bacteria;gut microbiome;gut microbiota;Heart;Heart failure;heart function;Heart Hypertrophy;Human;Hypertension;Hypertrophy;improved;interstitial;Knowledge;Lactobacillus;Left;Left Ventricular Dysfunction;Left Ventricular Function;Left Ventricular Hypertrophy;Measures;Mediating;Microbe;microbial;microbiome;MicroRNAs;Molecular;Mus;Myocardial;Myocardial dysfunction;new therapeutic target;Nonmuscle Myosin Type IIA;novel;novel therapeutics;Outcome;overexpression;Pathologic;Physiologic intraventricular pressure;pressure;prevent;Property;Reagent;receptor;Receptor Signaling;Reporting;Resistance;Risk;Risk Factors;Role;Serum;Shapes;Signal Transduction;Stress;Stretching;Testing;Therapeutic;Tissues;tool;Tryptamines;Tryptophan;Tryptophan Metabolism Pathway;Untranslated RNA;Up-Regulation;Vancomycin;Ventricular

PROJECT_TITLE: Glycopeptide vancomycin reshapes gut microbiota to mediate cardioprotective effects via microRNA-204

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ORLANDO

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: Project Narrative Skilled bimanual coordination is an important component of a wide range of activities of daily living. The proposed project aims at determining the neural mechanisms underlying the control of bimanual coordination when two limbs share a common goal. The knowledge gained in this project can provide significant insight to improve the effectiveness of motor rehabilitation interventions for restoring upper-limb function in individuals affected by neurological disorders.

PI_NAMEs: FU, QIUSHI  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Affect;Anterior;Area;Behavioral;Behavioral Paradigm;Bilateral;brain control;Central Nervous System;Cerebral Palsy;Characteristics;Clinical;clinical predictors;Complex;Data;design;Effectiveness;Electroencephalography;Electromyography;Event;Event-Related Potentials;evidence base;experimental study;flexibility;Food;Functional Magnetic Resonance Imaging;Future;Goals;grasp;Hand;Human;Impairment;improved;Individual;insight;Intervention;intraparietal sulcus;Investigation;Knowledge;Left;Left cerebral hemisphere;Lesion;Limb structure;Manuals;Maps;mechanical load;Medial;Modality;Motion;Motor;motor rehabilitation;Movement;multimodality;Nervous System Disorder;Neurologic;neurological rehabilitation;neuromechanism;neuroregulation;noninvasive brain stimulation;novel;Outcome;Parietal;Parietal Lobe;Participant;Patients;Pattern;Performance;Physiologic pulse;Rehabilitation therapy;Research;Resources;response;Role;Series;Signal Transduction;skills;spatiotemporal;Stroke;System;Task Performances;Testing;tool;Training;Transcranial magnetic stimulation;Translational Research;Upper Extremity;virtual;visual motor;visual tracking;Work

PROJECT_TITLE: Sensorimotor control of common-goal bimanual coordination

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE T cell receptors (TCRs), present as TCR-CD3 protein complexes on the T cell surface, detect cancer antigens (some fragments of cancer proteins) and direct the T cell to kill the tumor through various signaling mechanisms. One type of immunotherapy that involves altering TCR-CD3 mediated signaling can help the immune system to fight against deadly cancers. This proposal aims to identify and alter the critical amino acids (small molecules that constitute a protein) on the TCR that are involved in CD3-interactions and CD3-mediated signaling, leading to enhanced tumor killing by T cells as a means of devising new strategies for cancer immunotherapy of melanoma and other cancers.

PI_NAMEs: KROGSGAARD, MICHELLE  (contact);ZHU, CHENG

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Affinity;Amino Acids;anti-CTLA4;anti-PD-1;Antigen Targeting;Antigens;Antitumor Response;Avidity;Binding;Binding Sites;Biological Assay;Biosensor;Cancer Detection;cancer immunotherapy;CD3 Antigens;cell killing;Cell surface;Cells;Clone Cells;Complex;Cryoelectron Microscopy;CTLA4 gene;cytokine;cytotoxicity;Data;design;Development;Effectiveness;efficacy testing;engineered T cells;Event;exhaustion;experimental study;extracellular;fighting;Fluorescence Resonance Energy Transfer;functional outcomes;Goals;Human;Immune;immune checkpoint blockade;Immune system;Immunity;Immunotherapeutic agent;Immunotherapy;improved;in silico;In Vitro;in vivo;Interleukin-2;ITAM;Kinetics;Libraries;Ligation;Malignant Neoplasms;Mediating;Melanoma;Membrane;meter;Methodology;Methods;mouse model;Mutagenesis;mutant;Mutate;Mutation;Mutation Analysis;Names;neoplastic cell;novel;novel strategies;Patient-Focused Outcomes;Patients;Pattern;Peptide Vaccines;Peptide/MHC Complex;Phosphorylation;Phosphotransferases;Play;Production;programmed cell death protein 1;protein complex;Proteins;Publishing;Receptor Signaling;Regimen;Regulatory T-Lymphocyte;Research;response;Role;Signal Pathway;Signal Transduction;SILV gene;Site;small molecule;Specificity;Structure;T cell differentiation;T cell response;T cell therapy;T-Cell Activation;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Testing;therapy resistant;Time;Toxic effect;Transfection;tumor;Tumor Antigens;tumor initiation;tumor microenvironment;Work;ZAP-70 Gene

PROJECT_TITLE: Optimizing TCR-CD3 signaling for immunotherapy of cancer

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

PHR: Narrative Utilizing a state-of-the-art preclinical platform, this proposal aims to explore the therapeutic potential of novel strategies to target the common dependencies in heterogenous small cell lung cancer (SCLC) and to dissect the underlying mechanism, which will help develop tailored treatments for SCLC patients.

PI_NAMEs: KUFE, DONALD W.;WONG, KWOK KIN  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Accounting;Address;Adult;anti-PD-L1;anti-PD-L1 therapy;ASCL1 gene;ATAC-seq;Automobile Driving;BETA2 protein;Biology;Cancer Model;Cancer Patient;cancer subtypes;cancer therapy;chemotherapy;Clinical;Clinical Research;Data;Dependence;differential expression;Disease;dynamical evolution;efficacy evaluation;Epigenetic Process;Extensive Stage;Family;Gene Expression;Genetic Transcription;Goals;Human;Immune;Immune response;Immune system;Immunooncology;Immunotherapy;improved;In Vitro;in vivo;individualized medicine;inhibitor;Lung;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;member;mouse model;Mucin 1 protein;multidisciplinary;Mus;Neurosecretory Systems;novel strategies;Oncogenic;Patients;Pharmaceutical Chemistry;Pharmacodynamics;pre-clinical;programs;Recurrence;Resources;response;Role;single-cell RNA sequencing;small cell lung carcinoma;targeted agent;targeted treatment;Therapeutic;transcription factor;transcriptome;transcriptomics;Translational Research;Treatment Protocols;tumor;Tumor Immunity;tumor immunology;tumor initiation;tumor microenvironment;Universities;Work;Xenograft procedure

PROJECT_TITLE: Combining CDK7 and MUC1-C inhibition to target different subtypes of small cell lung cancer

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: NARRATIVE Our genetic hypercalciuric stone-forming rats are hypercalciuric, spontaneously form calcium-containing kidney stones, and have reduced bone mineral density and bone quality. We will use these rats as a model of idiopathic hypercalciuria in humans to study the relationship between hypercalciuria and bone mineral density and quality, as well as test potential pharmacologic interventions to improve bone. Our findings from these cellular and animal studies may lead to a substantial effect on treatment paradigms that will not only reduce recurrent stone formation but also improve bone quality in hypercalciuric patients.

PI_NAMEs: BUSHINSKY, DAVID A;LI, QIAOLI  (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: absorption;Address;Affect;Anabolic Agents;Animal Model;Animals;Binding;bisphosphonate;bone;bone cell;Bone Density;Bone Diseases;bone loss;bone quality;Bone Resorption;bone strength;Calcium;calcium absorption;calcium excretion;calcium metabolism;Calcium Oxalate;calcium phosphate;Clinical;Clinical Research;cortical bone;Defect;Diet;Diphosphates;disease model;Distal;Equilibrium;Etiology;Excretory function;FDA approved;Fracture;Future;Gene Expression;Generations;Genetic;Goals;Homeostasis;Human;hypercalciuria;improved;Inbreeding;Individual;inhibitor;inorganic phosphate;Intervention;Intestines;Kidney Calculi;Knowledge;Ligands;man;mechanical properties;Metabolic;Metabolism;Modeling;Monoclonal Antibodies;Nephrolithiasis;Nephrons;novel therapeutic intervention;novel therapeutics;Osteoblasts;Osteoclasts;Osteoporosis;Outcome;Pathogenesis;Patients;pharmacologic;Pharmacological Treatment;Phase;Physiological;Population;Prevalence;primary endpoint;Rat Strains;Rattus;Recurrence;renal calcium;Renal tubule structure;repository;Research Project Grants;Role;Serum;Serum Calcium Level;Skeleton;Solid;Source;substantia spongiosa;Testing;Therapeutic Uses;TNFSF11 gene;urinary;Urine;Vitamin D;Vitamin D3 Receptor

PROJECT_TITLE: Hypercalciuria and Abnormal Bone in the Genetic Hypercalciuric Stone-Forming Rats

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-W (05)]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Neurosciences;Prevention

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: Diabetes is the number one cause of vision loss in working aged Americans and a public health crisis of epidemic proportion. Furthermore, about 44% of Americans have prediabetes (a precursor to diabetes), and it is not currently known when, how, or where prediabetes affects the eye. This study will fully evaluate subjects with prediabetes and diabetes in many aspects of their health over time, to learn who will develop ocular changes and could be at risk for future vision loss.

PI_NAMEs: HARRISON, WENDY W (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Accelerometer;adaptive optics scanning laser ophthalmoscopy;Adult;Affect;Age;aged;American;Angiography;Area;Attention;Blindness;Blood;Blood capillaries;Blood Glucose;blood glucose regulation;Blood Vessels;Body Composition;Body fat;Cells;Characteristics;Chronic;Clinical;Cone;Confocal Microscopy;Cornea;Cross-Sectional Studies;Data;design;Diabetes Mellitus;Diabetic Retinopathy;Diagnosis;Disease Management;Early Diagnosis;Electroretinography;Epidemic;Eye;fasting glucose;Fatty acid glycerol esters;Film;Functional disorder;Future;Glucose;glucose tolerance;glycemic control;Glycosylated hemoglobin A;Goals;Health;high risk;Hour;Impaired fasting glycaemia;impaired glucose tolerance;Impairment;Individual;inflammatory marker;Intervention;Knowledge;Learning;lifestyle factors;Location;Measurable;Measures;Metabolic;metabolic phenotype;Methods;Nerve;neural;Neural Retina;Neuropathy;Neurophysiology - biologic function;Non-Insulin-Dependent Diabetes Mellitus;OGTT;Optical Coherence Tomography;Oxygen;Oxygen saturation measurement;Participant;Patients;Phenotype;Population;Prediabetes syndrome;prevent;Property;Prospective cohort;Prospective, cohort study;Public Health;Research;response;Rest;Retina;retina blood vessel structure;Risk;sedentary lifestyle;Structure;Testing;Time;timeline;tissue oxygenation;Tissues;tomography;Vision;Visit;Visual;Work

PROJECT_TITLE: Characterizing ocular structures and local retinal function in the progression of different objective phenotypes of prediabetes and type 2 diabetes

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE Bacteria, differently from mammals, assimilate inorganic sulfur into the amino acid, L-cysteine, the precursor of key metabolites including reducing agents, cofactors, and membrane components. Inhibition of cysteine biosynthesis interferes with the ability of pathogens to fight oxidative stress, to infect the host and to establish long-term infections. The proposed research is expected to lead to a new class of antibacterial agents that operate by a unique mechanism of action through disruption of sulfur metabolism.

PI_NAMEs: CARROLL, KATE SUZANNE (contact)

PROJECT_TERMS: Active Sites;Acute;Address;Adjuvant;Aerobic Bacteria;Amino Acids;Anabolism;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;antimicrobial;Attention;Bacteria;bacterial fitness;Bacterial Infections;bacterial metabolism;bactericide;Bacteriophages;Basic Science;biological adaptation to stress;Calorimetry;Cells;Cellular Assay;Chemicals;Chemistry;Clinical;cofactor;combat;Communicable Diseases;complement deficiency;COVID-19;COVID-19 patient;Crystallography;Cysteine;Development;drug development;Drug Targeting;electron donor;Electrons;Ensure;Environment;Enzyme Inhibition;enzyme mechanism;Enzymes;Escherichia coli;Exhibits;experimental study;Family;Ferredoxin-NADP Reductase;fighting;fitness;Funding;Gene Expression;Genes;genetic approach;Genetic Complementation Test;Genetic Transcription;Genome;Genus Mycobacterium;global health;Growth;Haemophilus influenzae;Human;human pathogen;Immune system;improved;in vivo;Infection;influenza infection;inhibitor;insight;Iron-Sulfur Proteins;isoniazid;Kinetics;Learning;Mammals;Measures;member;Membrane;Metabolic;Metabolic Pathway;Metabolism;meter;Microbe;microbial;Modern Medicine;Molecular Weight;Moraxella catarrhalis;mutant;mycobacterial;Mycobacterium tuberculosis;Mycobacterium tuberculosis H37Rv;National Institute of Allergy and Infectious Disease;National Institute of General Medical Sciences;Operon;Oral cavity;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;parent grant;pathogen;pathogenic microbe;Pathway interactions;Pharmaceutical Preparations;Plasmids;Play;Production;Proteins;Pseudomonas aeruginosa;Recombinants;Reducing Agents;Research;Resistance;Resources;response;Rifampin;scaffold;Series;Source;Specificity;Streptococcus Phages;Streptococcus pneumoniae;Structure;Sulfate;Sulfhydryl Compounds;Sulfides;Sulfites;Sulfur;Sulfur Metabolism Pathway;Testing;Titrations;transcriptome;Translating;tuberculosis drugs;TXN gene;Validation;Virulence;Virus

PROJECT_TITLE: Sulfur Metabolism in Human Pathogens

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Behavioral and Social Science;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Osteoarthritis;Pain Research;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Social Determinants of Health;Telehealth

ORG_CITY: BOSTON

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE This project is to determine the feasibility of a novel mindful exercise intervention for people with people with knee pain due to osteoarthritis. Additionally, the project will also examine the feasibility of conducting the study via telehealth and using digital tools for improved access to the intervention and recruitment of a racially and geographically diverse cohort of participants. If successful, this line of research may lead to an effective and accessible intervention to reduce pain and improve function for the millions of people with knee osteoarthritis.

PI_NAMEs: KUMAR, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: access disparities;Address;Adult;Affect;Affective;Age;arm;avoidance behavior;Behavior;Behavior Therapy;Behavioral Model;Belief;Biomechanics;Black race;Caring;chronic musculoskeletal pain;chronic pain;chronic pain management;clinical practice;Clinical Trials;cohort;Control Groups;Data;Decentralization;Degenerative polyarthritis;design;Devices;digital;digital tool;Disease;Effectiveness;effectiveness evaluation;effectiveness study;effectiveness trial;efficacy study;efficacy trial;electronic data;electronic data capture system;Emotional;emotional experience;Equity;Exercise;exercise intervention;exercise program;experience;Feasibility Studies;feasibility testing;Fright;functional improvement;Future;geographic disparity;Geography;Goals;Health Services Accessibility;Home;Impairment;Improve Access;improved;Individual;Internet;Intervention;intervention delivery;Intervention Trial;Knee Osteoarthritis;knee pain;Learning;Measures;mindfulness;mindfulness intervention;model development;Modeling;Movement;Muscle Weakness;novel;Outcome;Outcome Assessment;Pain;Pain management;pain reduction;Participant;Patient Outcomes Assessments;Patients;Persons;Physical activity;Physical Function;physical impairment;Physical therapy;pilot test;Population Intervention;psychologic;Psychological Impact;Race;racial disparity;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Resolution;Resources;response;Rural;Self Efficacy;sensor;Sensory;social media;Structure;Tai Ji;telehealth;Training;Translating;Treatment Efficacy;Underserved Population;United States National Institutes of Health;uptake;Videoconferencing;wearable sensor technology;Work;Yoga

PROJECT_TITLE: Telehealth Exercise and Mindfulness of Pain in knee Osteoarthritis (TEMPO): A digital Feasibility Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 KM (M2)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Sleep Research;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The proposed project will be among the first to examine the bidirectional and temporal associations between daily sleep dysregulation and smoking behavior and cessation outcomes using intensive longitudinal data via EMA and wearable sensors during a scheduled smoking cessation attempt among socioeconomically disadvantaged smokers. A better understanding of the relations between sleep dysregulation, smoking behavior, and smoking cessation will inform the development of novel interventions that address sleep dysregulation in smokers seeking cessation among socioeconomically disadvantaged smokers.

PI_NAMEs: RA, CHAELIN KAREN (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Abstinence;Accounting;actigraphy;adaptive intervention;Address;Adult;Attention;Attenuated;Behavior;Behavioral;Biochemical;Cancer Institute of New Jersey;Cellular Phone;cigarette smoke;cigarette smoking;Complex;Cross-Sectional Studies;Data;Data Analyses;Data Collection;Dependence;Development;Dimensions;Ecological momentary assessment;Environment;evidence base;Evidence based intervention;experience;Feeling;Funding;Future;health disparity;high risk;improved;improvement on sleep;Individual;interest;Intervention;Knowledge;Laboratories;Link;low socioeconomic status;Maintenance;Measures;Methodology;Methods;mHealth;mobile computing;Morbidity - disease rate;mortality;multilevel analysis;Nicotine Dependence;non-smoker;novel;Outcome;Participant;Pathway interactions;Patient Self-Report;Persons;Phase;poor sleep;Process;Public Health;Recommendation;Relapse;Research;Risk;Sampling;Schedule;secondary analysis;sensor;Services;Sleep;sleep behavior;Sleep Deprivation;Sleep disturbances;sleep health;sleep onset;sleep quality;Smoker;Smoking;smoking abstinence;Smoking and Health Research;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;smoking relapse;socioeconomic disadvantage;Socioeconomic Status;Substance Use Disorder;success;Survey Methodology;Surveys;Techniques;Technology;Testing;Time;Tobacco;Tobacco Use Disorder;Training;United States;United States National Institutes of Health;wearable device;wearable sensor technology;Withdrawal;Withdrawal Symptom;Wrist

PROJECT_TITLE: Using Mobile Technology to Examine Mechanisms Linking Sleep and Smoking Cessation

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Prevention;Sleep Research;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Sleep is a modifiable factor that supports healthy development; the quality and amount of sleep a youth gets is associated with a multitude of long-term health outcomes in adulthood. We propose to develop sleep growth charts of sleep macro- and microarchitecture using a combination of gold-standard, archival polysomnography data and accessible, at-home sleep recording devices. These resulting growth charts will serve as an essential template for the study of adolescent sleep development, improving detection of suboptimal sleep and enhancing personalized interventions.

PI_NAMEs: JALBRZIKOWSKI, MARIA ;SOEHNER, ADRIANE M. (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Development;Adult;Affect;Age;age effect;age related;age related changes;Alcohols;Architecture;Behavior;biobehavior;biological sex;Biological Testing;Boston;Brain;brain based;Childhood;Clinical;Cognitive;cohort;Communities;community setting;cost;Data;data archive;data harmonization;data repository;Detection;Development;Devices;disorder risk;Early Diagnosis;effective intervention;Electroencephalography;Environmental Risk Factor;ethnic identity;Gender Identity;Goals;Growth;Health;health care quality;health inequalities;Height;Heterogeneity;Home;Hormones;human old age (65+);improved;improvement on sleep;Individual;inter-individual variation;Intervention;Life;Link;Literature;Maps;Measurement;Measures;Medicine;Methodology;Methods;Modeling;National Institute of Mental Health;neurodevelopment;neuroimaging;non rapid eye movement;open source;Outcome;Participant;participant enrollment;Pediatric Hospitals;Pediatrics;personalized intervention;Persons;Phenotype;Physicians;Physiological;Play;Polysomnography;Populations at Risk;Proxy;Psyche structure;Puberty;racial identity;REM Sleep;Resources;Risk;Risk Assessment;Role;Sampling;sex;sexual identity;Sleep;sleep pattern;sleep physiology;sleep quality;social culture;sociocultural determinant;Source;Staging;standard measure;symptomatology;Testing;Time;tool;trend;Underserved Population;Universities;Validation;Variant;wearable device;Weight;Youth

PROJECT_TITLE: Developing Accessible Sleep EEG Growth Charts for Young People

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Many Americans living with serious illness and unmet palliative care needs who could benefit from palliative care never receive it. This pragmatic trial will test the effectiveness of using an automated trigger in the electronic health record to identify hospitalized patients with unmet palliative care needs with and without an additional gentle nudge for clinicians to consider consulting palliative care. This study will also examine how these approaches impact the equity of palliative care consultation, and key implementation barriers and other contextual factors that may influence their effectiveness and translation to other health systems.

PI_NAMEs: COURTRIGHT, KATHERINE RINALDI (contact);HARHAY, MICHAEL OSCAR

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: access disparities;acute care;Address;Adopted;Adoption;advanced disease;Advisory Committees;Affect;American;arm;Beds;behavior change;Behavior Therapy;Black race;care delivery;Caregivers;Caring;Clinical;Cluster randomized trial;cluster trial;Collaborations;Communities;comparative;Consult;Consultations;contextual factors;Data;design;Diagnosis;Diagnostic;Disparity;Disparity population;economic outcome;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness study;effectiveness testing;effectiveness/implementation trial;Electronic Health Record;end of life;Equity;Ethnic Origin;Exclusion;experience;Goals;Guidelines;Health;Health Services Accessibility;Health system;Heterogeneity;hospice utilization;hospital readmission;Hospitalization;Hospitals;Hybrids;implementation barriers;implementation context;implementation framework;improved;improved outcome;Inequity;innovation;Inpatients;Intervention;Interview;Investments;Knowledge;Length of Stay;Location;Maintenance;Malignant Neoplasms;Manuals;Maryland;Medicaid;Methodology;Methods;Modification;mortality;older patient;operation;Outcome;palliative;Palliative Care;participant enrollment;patient oriented;Patient Outcomes Assessments;patient subsets;Patient-Focused Outcomes;Patients;Population Heterogeneity;pragmatic trial;preference;primary outcome;Process Measure;Prognosis;prognostic;programs;provider behavior;Proxy;Quality of life;Race;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Role;screening;secondary outcome;Site;social disparities;Source;Specialist;Structure;Subgroup;Symptoms;System;Testing;Time;Translations;treatment as usual;trial design;Use Effectiveness;Work

PROJECT_TITLE: Improving the delivery and equity of inpatient palliative care: a hybrid type I pragmatic cluster trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Lung;Precision Medicine;Pulmonary Hypertension;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Pulmonary arterial hypertension is a relentless disease characterized by vascular obliteration, right heart failure and death; approximately 40% of patients are dead within 5 years of diagnosis. This grant aims to use advanced genetic and Omic techniques to select patients most likely to benefit from prostacyclin therapy, the most potent therapy available with a portion of patients having marked improvement. The long term goal is to correctly match a patients unique biology to the appropriate therapy in PAH, thereby improving outcomes in this highly morbid disease.

PI_NAMEs: HEMNES, ANNA R (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Acute;Address;biobank;Biology;Blood Vessels;Calcium Channel Blockers;Cell Physiology;Cells;Cessation of life;Clinical;cohort;Complement component C5;cytokine;Data;Diagnosis;Disease;DNA;Enrollment;Epoprostenol;FDA approved;Funding;Future;Genes;Genetic;genetic association;Genetic Transcription;genome wide association study;genomic data;Genomics;Glucose;Goals;Grant;IL17 gene;Immune;Immune Tolerance;Immunophenotyping;improved;improved outcome;Inflammatory;Inhalation;insight;Interleukin-5;Link;Macrophage;Measures;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic dysfunction;Mitochondria;Molecular;mouse model;Oral;Oxygen Consumption;Patient Selection;Patients;Pattern;personalized medicine;Pharmaceutical Preparations;Phenotype;Plasma;polygenic risk score;Population;precision medicine;predicting response;primary pulmonary hypertension;Production;prospective;Prospective cohort;Prostaglandins I;Publishing;pulmonary arterial hypertension;pulmonary arterial pressure;pulmonary vascular disorder;Regulatory T-Lymphocyte;Reporting;response;right ventricular failure;Role;Severity of illness;T-Lymphocyte;Techniques;Testing;Transplantation;treatment response;Validation;Variant;Vasodilator Agents;Work

PROJECT_TITLE: Genomic and Circulating Predictors of PAH response

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_DEPT: SURGERY

PHR: Project Narrative Nucleic Acid Scavengers for Combating Pancreatic Cancer Dead and dying cancer cells release nucleic acids. These extracellular RNAs and DNAs can be recognized as Damage Associated Molecular Patterns (DAMPs) and taken up by inflammatory and/or cancer cells and activate them. In this study we will determine how DAMP-induced inflammation impacts cancer progression and metastasis and investigate if blocking nucleic acid debris-induced inflammation using compounds that scavenge tumor debris will augment antitumor responses, thereby providing rationale for inclusion of such inflammation blocking agents in therapeutic strategies for treating patients with pancreatic cancer. We have preformed preliminary studies indicating that such “nucleic acid scavengers” can limit metastasis in animal models of cancer. Herein we propose to perform detail preclinical studies with such novel therapeutic agents to facilitate the translation of this approach to the clinic. Successful completion of these studies will yield a novel strategy as well as lead therapeutic agents to treat pancreatic cancer as well as potentially other solid tumors. Thus these studies are greatly needed and highly clinically significant.

PI_NAMEs: SULLENGER, BRUCE ALAN (contact);WHITE, REBEKAH

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Address;Adjuvant;Animal Cancer Model;Animal Model;Anti-Inflammatory Agents;Antitumor Response;Biochemistry;Biodistribution;Blood Platelets;cancer cell;Cancer Control;Cancer Patient;cancer therapy;cell motility;Cells;chemotherapy;Chronic;Clinic;Clinical Research;clinically significant;combinatorial;curative treatments;Cyclodextrins;Data;design;Disease;Disease Progression;Distant;Distress;DNA;DNA delivery;Dose Limiting;Excision;extracellular;Generations;Human;Immune;immune activation;immune function;improved;improved outcome;In Vitro;in vivo;Infection;Inflammation;Inflammatory;innovation;Invaded;Laboratories;Lead;Liver;Lupus;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Melanoma;Melanoma patient;Metastasis Induction;migration;Modeling;Molecular;mouse model;Mus;Natural Immunity;Nature;Neoplasm Metastasis;novel strategies;novel therapeutics;Nucleic Acid Binding;Nucleic Acids;Operative Surgical Procedures;Organoids;Outcome;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;pathogen;patient derived xenograft model;Patients;Pattern;Pattern recognition receptor;Phase;Polymers;preclinical study;preconditioning;Primary Neoplasm;Process;Prognosis;protein complex;Publishing;Recurrence;Reporting;response;RNA;RNA delivery;Safety;Sampling;Signal Transduction;siRNA delivery;Site;Solid Neoplasm;synergism;T cell infiltration;Therapeutic;Therapeutic Agents;Toll-like receptors;Toxic effect;Translating;translational approach;Translations;tumor;Tumor Immunity;tumor progression;Tumor Promotion;tumor xenograft;tumorigenic;Variant;Work

PROJECT_TITLE: Utilizing nucleic acid scavengers to elucidate how DNA/RNA-containing DAMPs promote pancreatic cancer metastasis and to mitigate such processes


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Disability Research;Hearing Loss;Neurosciences;Pediatric

PHR: Project Narrative This project addresses one of the most highly debated questions for caregivers of deaf and hard of hearing (DHH) children: whether to use sign language, spoken language, or both. We aim to leverage a large, prospective, population-based sample of DHH children to identify indicators for expressive language growth needed to “catch up” to peers with typical hearing and to reveal the influence of access to American Sign Language and spoken English on language growth. This knowledge is critical for improving language, academic, vocational, and social outcomes for DHH children, a historically under researched group.

PI_NAMEs: MCDANIEL, JENA C (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 8 year old;Address;Affect;Age;American Sign Language;Birth;Caregivers;Categories;Child;Clinical;Code;Collaborations;Communication;Costs and Benefits;Data;Data Set;Data Sources;deaf;Development;Diagnosis;Educational process of instructing;Environmental Risk Factor;Evaluation;expectation;Exposure to;Face;Foundations;Future;Goals;Growth;Guidelines;hard of hearing;Harvest;Hearing;improved;improved outcome;Individual;innovation;Intervention;Kansas;Knowledge;Language;Language Development;Language Disorders;language outcome;Learning;Left;Measures;Modeling;Natural History;novel;Oral;Outcome;Parents;Participant;peer;population based;Positioning Attribute;Predictive Value;programs;prospective;Recording of previous events;recruit;Research;Resources;Risk;Sampling;Services;Sign Language;skills;social implication;Social outcome;Source;Standardization;Testing;Time;tool;Variant;Vocation;wasting

PROJECT_TITLE: American Sign Language and Spoken English Development of Young Deaf and Hard of Hearing Children

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Failure to appropriately regulate fear in situations that should be considered safe can be observed in stress disorders, such as Post-Traumatic Stress Disorder (PTSD). The precise neural circuits promoting the adaptive response of conditioned inhibition of fear to safety cues that are well discriminated from threat cues are poorly understood. The proposed work will test the neural circuitry underlying 3 main aspects of a learned safety cue: 1) how it suppresses fear under potential safety/threat conflict, 2) how it overlaps with and may acquire rewarding properties, and 3) how it adaptively regulates fear in novel contexts.

PI_NAMEs: SANGHA, SUSAN  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Affect;Amygdaloid structure;Anterior;Area;Arousal;Articulation;Behavior;Behavior Control;Behavioral;Cells;cingulate cortex;Conditioned Reflex;conditioning;Conflict (Psychology);Cues;Discrimination;Discrimination Learning;Effectiveness;Environment;experience;experimental study;Exposure to;Extinction;Failure;Fright;Funding;Human;Individual;inhibitor;Learning;Link;Medial;Medical;Memory;Mental disorders;neural circuit;neuromechanism;Neurons;novel;Nucleus Accumbens;optogenetics;Post-Traumatic Stress Disorders;Prefrontal Cortex;Property;Qualifying;Rattus;recruit;response;reward processing;Rewards;Rodent;Role;Safety;safety testing;Signal Transduction;stress disorder;Testing;Training;translational approach;Treatment outcome;Work

PROJECT_TITLE: Neural circuitry of safety, fear and reward cue discrimination

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: LOGAN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PHR: PROJECT NARRATIVE Listener training offers a promising avenue for improving communication for people with dysarthria due to Parkinson's disease by offsetting the intelligibility burden from the patient onto their primary communication partners. Here, we employ a repeated-measures, randomized controlled trial to establish the efficacy of listener training for patients with PD and their primary communication partners. This translational work will establish a new realm of clinical practice in which the intelligibility impairments in PD are addressed by training partners to better understand dysarthric speech, thus elevating communication outcomes and participation in daily life.

PI_NAMEs: BORRIE, STEPHANIE ANNA (contact);LANSFORD, KAITLIN LORRAINE

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Adult;Behavioral;bench to bedside;causal model;Clinic;Clinical;clinical care;clinical implementation;clinical practice;Cognitive;Communication;Communication difficulty;comparison control;Comprehension;Disease;Disease Management;Documentation;Dysarthria;Educational Intervention;effective therapy;Effectiveness;efficacy evaluation;empowerment;Ensure;Evaluation;Exhibits;experience;Family;Family member;Goals;Health Professional;human old age (65+);Impaired cognition;Impairment;improved;information gathering;insight;Intervention;Intervention Studies;Interview;Investigation;Life;Measures;Modeling;multilevel analysis;novel;older adult;Outcome;Parkinson Disease;Participant;Partner Communications;Patient Education;Patients;Perceptual learning;Persons;Physical Efforts;physical impairment;Population;Positioning Attribute;preference;programs;Randomized;Randomized, Controlled Trials;recruit;Rehabilitation therapy;remediation;Reporting;Research;Role;Sampling;Severities;Signal Transduction;social;Social isolation;Speech;Speech Therapy;stakeholder perspectives;Structure;Techniques;Testing;Theoretical model;theories;therapy development;Time;Training;Training Programs;Weight;Work

PROJECT_TITLE: Listener training for improved intelligibility of people with Parkinson's disease


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: SAN MARCOS

ORG_DEPT: CHEMISTRY

ORG_NAME: TEXAS STATE UNIVERSITY

PHR: Public Health Statement: Optical microscopes are a critical tool for understanding basic cellular functions which is needed to support basic biomedical research and modern undergraduate and graduate training in the life sciences. The requested widefield fluorescence microscope is requested to bring new modern scientific equipment to enhance the biomedical research capacity and educational mission of TX State University which is an under-resourced and minority-serving institution. Engaging students at institutions like TX State University with many different backgrounds and life histories is important to building the next diverse generation of scientific workers that will make future scientific discoveries and develop new technologies to improve human health.

PI_NAMEs: PETERSON, RYAN LOREN (contact)

PROGRAM_OFFICER_NAME: BECKETT, DOROTHY

PROJECT_TERMS: Applications Grants;Basic Science;Biochemistry;Biology;Biomedical Research;cancer cell;Cell Culture Techniques;Cells;Chemistry;Color;Communities;Complement;Development;Documentation;Education;Educational process of instructing;Engineering;Equipment;equipment acquisition;Equipment Safety;experience;fluorescence microscope;Funding;high resolution imaging;imaging capabilities;Institution;Instruction;instrument;Laboratories;Life;live cell imaging;Maintenance;materials science;matriculation;Microbe;Microbiology;Microscope;Microscopy;Mission;Modeling;Modernization;operation;Procedures;programs;Protocols documentation;Request for Proposals;Research;Research Personnel;Resolution;Resource Sharing;Resources;Schedule;Science;student participation;Students;Texas;Training;Training Programs;undergraduate student;United States National Institutes of Health;Universities

PROJECT_TITLE: Fluorescence Microscope with Live-cell and high-resolution imaging capabilities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (30)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Pediatric;Rehabilitation

PHR: Project Narrative An estimated 1 in 89 school-age children have profound speech impairments due to a range of neurodevelopmental disorders, resulting in a pressing public health need to improve the discovery of viable communication solutions other than speech that promote maximal language growth. Because the project is focused on developing valid measures to characterize the expressive language skills of these children, the project is relevant to NIDCD’s mission to address the biomedical and behavioral problems associated with individuals who have communication disorders, including children with Down syndrome (which aligns with NIH INCLUDE’s plan to conduct clinical research to assess the efficacy of interventions for improved communication). Failing to conduct this research blocks advancement in rigorous AAC research, resulting in continued reliance on psychometrically questionable measures.

PI_NAMEs: BINGER, CATHY ;KENT-WALSH, JENNIFER  (contact)

PROJECT_TERMS: accurate diagnosis;Achievement;Address;Adult;Affect;alternative communication;Augmentative and Alternative Communication;Canis familiaris;Cerebral Palsy;Child;Child Language;Clinical;clinical practice;Clinical Research;Code;Communication;Communication impairment;Communication Research;Data;Data Collection;Data Set;design;Development;Developmental apraxia;Differentiation and Growth;Dimensions;Down's Syndrome;efficacy evaluation;Goals;Growth;Impairment;improved;Individual;interest;Intervention;Investigation;Language;Language Development;Language Disorders;language outcome;Length;literate;Measures;Mission;Monitor;National Institute on Deafness and Other Communication Disorders;Neurodevelopmental Disorder;Outcome;Performance;Phase;Phenotype;Play;Population;Problem behavior;Procedures;Production;Productivity;Property;Psychometrics;Public Health;Publications;Research;Research Design;Research Personnel;Resort;School-Age Population;Series;skills;sound;Speech;Speech Disorders;Time;Treatment Efficacy;United States National Institutes of Health;Work

PROJECT_TITLE: Measuring Aided Language Development


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

PHR: Project Narrative Identifying the neural underpinnings of auditory perceptual timing deficits will elucidate the mechanisms of perceptual and cognitive organization dysfunction in schizophrenia. Understanding the mechanisms of auditory perceptual disorganization in schizophrenia will provide insight into core aspects of the disease and guide novel diagnostic and therapeutic approaches.

PI_NAMEs: COFFMAN, BRIAN A (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Abnormal coordination;Affect;Anisotropy;Area;Attention;Attenuated;Auditory;Auditory area;Auditory Perception;Behavior;Behavioral;behavioral impairment;Brain;Cerebellar Nuclei;Cerebellum;Clinical;Cognitive;cognitive function;cognitive process;Corpus striatum structure;Data;debilitating symptom;Diffusion;Disease;early psychosis;Electroencephalography;Ensure;Evaluation;experimental study;Fingers;first episode schizophrenia;Functional disorder;Functional impairment;Future;Globus Pallidus;Goals;Impaired cognition;Impairment;Individual;insight;Intervention;Lateral;Link;Magnetoencephalography;Measures;Medulla oblongata olive;Motor;multimodality;neural;Neuroanatomy;Neurobiology;neuromechanism;neurophysiology;novel diagnostics;novel therapeutic intervention;Participant;Pathology;Pattern;pattern perception;Perception;perceptual organization;Performance;Periodicity;Phase;Positioning Attribute;Process;Psychoses;psychotic;Publishing;putamen;recruit;Research;Resolution;response;Schizophrenia;schizophrenia spectrum disorder;Sensory;sensory cortex;Sensory Process;sequence learning;Series;Societies;Source;Specificity;spectrograph;stimulus processing;Structural defect;Structure;Structure of subthalamic nucleus;Symptoms;System;Thalamic structure;therapeutic target;Time;Time Perception;United States;white matter

PROJECT_TITLE: Neurophysiology of Distributed Predictive Timing Systems in Early Psychosis

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Childhood Leukemia;Clinical Research;Down Syndrome;Hematology;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Children with Down Syndrome (DS) have a 20-fold increased risk of developing acute lymphoblastic leukemia (ALL) with significantly lower overall survival in comparison to children without DS who have ALL. This is due in part to the 3- to 10-fold higher risk of infection-related mortality during chemotherapy for ALL. Proposed studies in this application will investigate potential biomarkers for risk of fatal infection in DS patients with ALL to stratify these patients into high and low risk cohorts to guide treatment regimens.

PI_NAMEs: GUIDOS, CYNTHIA J.;RABIN, KAREN R;RYEOM, SANDRA  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Lymphocytic Leukemia;attenuation;Bacterial Infections;Biological Assay;Biological Markers;biomarker identification;Blood;Blood Cells;Blood specimen;Calcineurin;Calcineurin inhibitor;Calcineurin Pathway;candidate validation;case control;Cells;Cellular Immunity;Chemotaxis;Chemotherapy-Oncologic Procedure;Child;Childhood;Childhood Acute Lymphocytic Leukemia;Chromosome 21;circulating biomarkers;clinical phenotype;Clinical Trials;cohort;Constitution;cytokine;Cytometry;Data;Defect;Development;Dexamethasone;Disease Outcome;Disease-Free Survival;Disparity;Down's Syndrome;Enrollment;Exposure to;Gene Expression;General Population;Genetic;genetic epidemiology;genetic variant;Genetically Engineered Mouse;Germ Lines;Goals;high risk;Immune;immune function;Immunologic Markers;Immunosuppression;Impairment;improved;improved outcome;Individual;Infection;infection rate;infection risk;Inferior;innate immune function;Innate Immune System;Interferons;Intervention;Knowledge;Lead;Leukemia Acute Lymphoblastic Chemotherapy;leukemia treatment;Life;Life Experience;Modification;mortality;mortality risk;mouse model;Mus;Mycoses;novel;Outcome;pathogen;pathogenic bacteria;pathogenic fungus;patient stratification;Patients;Pediatric Oncology;Pediatric Oncology Group;Phagocytosis;Plasma;Pneumonia;Population;potential biomarker;Predisposition;prevent;Production;prospective;Quality of life;Relapse;relapse risk;Risk;risk stratification;Sepsis;Signal Transduction;Supportive care;Survival Rate;T-Lymphocyte Subsets;Toxic effect;Treatment Protocols;treatment risk;Vincristine;Virus Diseases;Vulnerable Populations

PROJECT_TITLE: Preventing Fatal Infections in Children with Down Syndrome During Treatment for Acute Lymphoblastic Leukemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (57)]


NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Pseudomonas aeruginosa is the major cause of morbidity and mortality for people with Cystic Fibrosis (CF). Using a specialized model system to culture P. aeruginosa biofilms in association with human CF airway epithelial cells, we have observed that virus co-infections promote chronic infection by P. aeruginosa. The studies proposed in this application will define metabolic changes during viral-bacterial co-infections in the CF airway that promote chronic bacterial infections, and likely identify new therapeutic targets that could be exploited to delay acquisition or work in conjunction with existing therapies, to eradicate P. aeruginosa infections in CF.

PI_NAMEs: BOMBERGER, JENNIFER MELINDA (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Accounting;Acute;aerobic glycolysis;airway epithelium;Anti-Bacterial Agents;Anti-viral Response;Antibiotic Resistance;Antibiotic Therapy;antimicrobial;Arbitration;Bacterial Infections;Biogenesis;Biological Availability;Biological Models;Bronchiectasis;Cell Physiology;cell type;Characteristics;Chronic;Chronic Disease;chronic infection;Chronic Obstructive Pulmonary Disease;co-infection;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis airway epithelia;cystic fibrosis patients;Cytoprotection;Data;design;Development;Disease;Environment;Epithelial Cells;Epithelium;Fostering;Functional disorder;Genes;Goals;Growth;HIF1A gene;Human;Immune;Immune response;Immunologics;Impairment;improved;In Vitro;in vivo;Infection;Influenza A virus;Integration Host Factors;Interferons;Iron;Lung;lung injury;Macrophage;Malignant Neoplasms;Mediating;Metabolic;metabolic profile;Microbial Biofilms;Microbial Physiology;Modeling;Molecular;Morbidity - disease rate;mortality;Mucociliary Clearance;Mucous Membrane;Mus;new therapeutic target;opportunistic pathogen;Oranges;Oxidants;Oxidative Phosphorylation;Oxidative Stress;Oxidative Stress Induction;pathogen;Pathogenesis;pathogenic virus;Pathway interactions;Pentosephosphate Pathway;Persons;Phenotype;polymicrobial biofilm;preservation;prevent;programs;promote resilience;Property;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pulmonary Cystic Fibrosis;Reactive Oxygen Species;recruit;Regulation;Reporting;Research;respiratory examination;respiratory infection virus;respiratory pathogen;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory System;respiratory virus;response;Role;Seasons;Signal Induction;Signal Transduction;Signaling Molecule;Surface;synergism;Testing;Time;Viral;Viral Physiology;Viral Respiratory Tract Infection;Virus;Virus Diseases;Work

PROJECT_TITLE: Regulation of viral-bacterial co-infections by immunometabolism

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative Sounds generated by the inner ear, otoacoustic emissions, offer much untapped clinical potential. Their clinical need is expected to increase with demands for early and accurate detection of problems of the ear. The proposal creates the foundation for such advanced uses.

PI_NAMEs: DHAR, SUMITRAJIT  (contact);GOODMAN, SHAWN S

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: accurate diagnosis;Adoption;age related;age related changes;Aging;Audiology;Auditory;Biological Assay;Calibration;Cell Therapy;Clinic;Clinical;clinical application;clinical practice;Cochlea;Detection;Deterioration;Development;Diagnostic;diagnostic tool;Differential Diagnosis;Ear;Early Diagnosis;efficacy evaluation;Electrochemistry;Evaluation;experience;experimental study;Exposure to;Foundations;Frequencies;Friends;Goals;Growth;Hair Cells;Health;Hearing;hearing impairment;Human;Individual;innovation;Joints;Laboratories;Labyrinth;Masks;Measures;mechanical properties;Metabolic;Modernization;Monitor;next generation;Noise;noise exposure;normal hearing;novel;novel diagnostics;novel therapeutics;otoacoustic emission;Outer Hair Cells;Output;Pathology;Pattern;Peer Review;performance tests;personalized diagnostics;pharmacologic;Property;Protocols documentation;Psychoacoustics;Publishing;restoration;Role;Sampling;Screening procedure;Sensitivity and Specificity;Sensory;Signal Transduction;sound;speech in noise;stem cells;Stimulus;Techniques;Tissue Preservation;Tissues;tool;Translating;two-dimensional;Work

PROJECT_TITLE: Next Generation OAEs

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Bacterial cells must detect and adapt to a broad range of chemical and physical signals in their environment to survive. Understanding the regulatory mechanisms that govern adaptive cellular responses can greatly impact our ability to manipulate and control bacterial growth. This project focuses on characterization of a conserved stress response genes that determine survival of the pathogenic bacterium, Brucella abortus, inside a mammalian host.

PI_NAMEs: CROSSON, SEAN  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: acute stress;Agriculture;Alphaproteobacteria;assault;Attenuated;Bacteria;Binding;Biochemical;Biogenesis;biological adaptation to stress;Biology;Brucella;Brucella abortus;Brucellosis;cell envelope;Cells;Chemicals;chronic infection;Containment;Cues;Data;Defect;Detection;DNA-Directed RNA Polymerase;Environment;environmental stressor;Experimental Genetics;experimental study;Family;gene conservation;Gene Expression;Genes;Genetic Transcription;Goals;Growth;Health;Human;In Vitro;in vivo;Infection;Investigation;Light;Lipids;Lipoproteins;Livestock;Mammals;Membrane;microbial;Modeling;Molecular;Molecular Chaperones;Mus;mutant;Output;overexpression;paralogous gene;pathogen;pathogenic bacteria;Pathway interactions;periplasm;Periplasmic Proteins;Phosphorylation;Phosphotransferases;Play;posttranscriptional;Process;Protein Dephosphorylation;Protein Secretion;protein-histidine kinase;Proteins;Proteobacteria;Publishing;Regulation;Repression;Research Personnel;Research Proposals;Resistance;response;RNA;RNA Binding;Role;sensor;sensor histidine kinase;Sensory;sensory system;Signal Pathway;Signal Transduction;Small RNA;Spontaneous abortion;Stress;Stress Response Signaling;System;Testing;Transcriptional Regulation;yeast two hybrid system;Zoonoses

PROJECT_TITLE: Regulation of the Brucella abortus general stress response

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: CORAL GABLES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Precise control of inflammation is essential for restoring tissue homeostasis in the injured retina. We recently demonstrated that the cytokine IL-27 regulates inflammatory signals during retinal degeneration, protects photoreceptors and rescues vision in a mouse model of inherited retinal degeneration. The proposed study will build upon this exciting data by defining mechanisms by which IL-27 signaling controls inflammation and promotes photoreceptor survival and will identify whether Muller glia-microglia interactions are key for IL-27-mediated retinal protective activity. This research is relevant to public health by identifying regulatory signals that control inflammation during retinal degeneration and characterizing a potential therapeutic strategy.

PI_NAMEs: HACKAM, ABIGAIL S (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acceleration;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Autophagocytosis;Binding;Biological Assay;cell type;Cells;Cessation of life;conditional knockout;cytokine;Cytokine Receptors;Data;Disease;experimental study;Flow Cytometry;Foundations;Genes;Goals;Homeostasis;Human;IL27RA gene;improved;Infection;Inflammation;Inflammatory;Inflammatory Response;inherited retinal degeneration;inhibitor;injured;insight;Interleukins;intravitreal injection;knock-down;Knockout Mice;Macrophage;Mediating;Microglia;migration;mouse model;Muller's cell;Mus;mutant;Mutation;Natural Immunity;neuroinflammation;neuronal survival;neuronal tumor;Neurons;neuroprotection;neurotoxic;novel;novel therapeutic intervention;Nuclear;overexpression;Oxidative Stress;Pathway interactions;Phagocytosis;photoreceptor degeneration;Photoreceptors;preservation;prevent;Public Health;Reaction;receptor;Receptor Signaling;Recombinant Interleukins;recruit;Research;response;Retina;Retinal Cone;retinal damage;Retinal Degeneration;Retinal Diseases;Rodent;Role;Signal Transduction;single-cell RNA sequencing;Testing;Therapeutic;Time;Tissues;transcriptomics;tumor;Vertebrate Photoreceptors;Vision;Visual Acuity

PROJECT_TITLE: Investigating mechanisms of IL-27-induced photoreceptor protection and rescued vision

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-F (02)]


ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Cardiovascular diseases (CVD) remain the leading cause of death in the US and worldwide, requiring development of innovative therapies for CVD prevention and treatment. In this proposal, we will develop non- viral gene editing therapeutic strategies targeting ASGR1 in the rabbit model of atherosclerosis for treating hyperlipidemia and CVD.

PI_NAMEs: CHEN, YUQING EUGENE;HAN, RENZHI  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 5'-AMP-activated protein kinase;Address;adeno-associated viral vector;Adopted;Animal Model;Animals;Asialoglycoprotein Receptor;Asialoglycoproteins;atherogenesis;Atherosclerosis;atorvastatin;base editing;base editor;basolateral membrane;Cardiovascular Agents;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular disorder therapy;Cardiovascular Models;cardiovascular risk factor;Cause of Death;Cells;Cholesterol;Cholesterol Synthesis Inhibition;clinical application;Clinical Treatment;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Dangerousness;Development;Diet;DNA;DNA Double Strand Break;Dose;Duchenne muscular dystrophy;Dyslipidemias;efficacy evaluation;Elements;Engineering;Event;Excretory function;experience;experimental study;Family suidae;FDA approved;Frequencies;gene editing technology;gene therapy;Generations;Genes;Genetic study;Genome;genome editing;genotoxicity;Germ Cells;Glycoproteins;Guide RNA;Guidelines;Hepatocyte;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Human;human disease;Human Genetics;Hyperlipidemia;Immune response;In Vitro;in vivo;Incidence;inhibitor;Innovative Therapy;insight;knockout gene;Knowledge;LDL Cholesterol Lipoproteins;Lesion;Light;Link;lipid metabolism;Lipids;loss of function mutation;Low-Density Lipoproteins;Mediating;Methods;Modeling;mouse model;Mus;Neurons;new therapeutic target;New Zealand;Nonsense Mutation;novel;Oryctolagus cuniculus;particle;Patients;Pharmaceutical Preparations;plasmid DNA;Point Mutation;Positioning Attribute;Pre-Clinical Model;Proteins;Recommendation;Recurrence;Reporting;Research;Residual state;Ribonucleoproteins;Risk;Route;Running;Safety;safety engineering;Serum;Technology;Testing;Therapeutic;therapeutic development;therapeutic genome editing;therapeutic target;tool;Transcript;translational study;Treatment Efficacy;Triglycerides;Tumorigenicity;uptake;Very low density lipoprotein;Viral;Virus-like particle

PROJECT_TITLE: Targeted editing of ASGR1 for cardiovascular diseases

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE This research aims to understand and disrupt the mechanisms by which some cancers evolve and become resistant to treatments. By studying a specific enzyme called APOBEC3A that is involved in cancer evolution, and testing ways to inhibit its activity, the project seeks to extend the effectiveness of cancer therapies, ultimately enhancing health, prolonging life, and reducing the burden of cancer-related illness and disability.

PI_NAMEs: LAWRENCE, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Ablation;acquired drug resistance;Address;Affinity;anti-cancer;Antineoplastic Agents;apolipoprotein B mRNA editing enzyme;Biochemical;Biological Assay;Bladder;Breast;Cancer Burden;cancer cell;Cancer cell line;cancer drug resistance;cancer genome;cancer therapy;carcinogenesis;Cell Line;Cells;Cervical;Clinical;Computer Analysis;CRISPR/Cas technology;Cytidine Deaminase;deep learning;Diagnostic;disability;DNA;Drug resistance;Effectiveness;efficacy evaluation;efficacy testing;empowerment;Enzymes;Epidermal Growth Factor Receptor;Evolution;exome sequencing;Family member;fitness;genome editing;Genomic DNA;genomic profiling;Genomics;Genotoxic Stress;Head and Neck Cancer;Health;Human;In Vitro;Incidence;Infection;Inflammatory Response;inhibitor;Innate Immune System;Life;Lung;lung cancer cell;Malignant Neoplasms;malignant oropharynx neoplasm;Measures;Mediating;men;Methods;mimetics;Modeling;Molecular;molecular dynamics;Monitor;Mutagenesis;Mutate;Mutation;novel;novel diagnostics;Oligonucleotides;Oncogenes;Patients;polypeptide;Predisposition;preference;pressure;Primary Neoplasm;Property;Proteins;Proteomics;Reporter;Research;Resistance;RNA;RNA Editing;Role;Sequence Analysis;Shapes;Site;Source;Structure;Suggestion;targeted cancer therapy;targeted treatment;Testing;therapy resistant;Time;tool;transcriptome;transcriptomics;Transfection;tumor;tumor xenograft;tumorigenesis;Vertebral column;Virus;Work

PROJECT_TITLE: Mechanisms of APOBEC3A-induced cancer evolution and cancer vulnerability

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE It is still unclear why some prostate cancers remain indolent for decades, yet others progress rapidly and fail to respond to standard-of-care hormone therapy. We and others have found that markers of cellular senescence, a stress pathway induced by oncogenic signaling that can impact tumor growth and immune activity, are present in mouse and human prostate cancer lesions. This proposal aims to address the functional contribution of senescence and specific senescent cell populations to prostate tumor onset and progression, immune suppression, and immunotherapy responses, and by doing so not only develop new senescence-related biomarkers prognostic of disease progression, but also novel immune-based targets and therapeutic strategies for treating prostate cancer.

PI_NAMEs: RUSCETTI, MARCUS A. (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Ablation;Address;American;androgen independent prostate cancer;anti-PD-1;Automobile Driving;BCL1 Oncogene;Biological Markers;biomarker identification;Cancer Control;Cancer Etiology;cancer initiation;Cancer Patient;Castrate sensitive prostate cancer;Cell Aging;Cell Cycle Arrest;Cell Lineage;cell type;Cells;Cessation of life;Chemosensitization;Chronic;Data;Death Rate;Development;Disease;Disease Progression;Epithelium;Fostering;Genetic;Genetically Engineered Mouse;Genomics;Heterogeneity;hormone therapy;Human;human cancer mouse model;Immune;immune checkpoint blockade;immune clearance;immune function;Immune response;Immunity;immunoregulation;immunosenescence;Immunosuppression;Immunotherapy;Indolent;Inflammation;inhibitor;Lead;Lesion;male;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Modeling;Molecular;mouse model;Mus;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Oncogenic;Pathway interactions;patient subsets;Patients;pharmacologic;Phenotype;phenotypic biomarker;Play;Population;pre-clinical;premalignant;Premalignant Cell;Production;Prognostic Marker;programs;Property;Prostate;prostate cancer model;prostate carcinogenesis;Prostatic Neoplasms;Refractory;Relapse;Research;response;Role;Sampling;Science;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Senotherapy;Signal Transduction;Stains;standard of care;Stress;Stromal Cells;synergism;systemic inflammatory response;T cell response;T-Lymphocyte;targeted treatment;Therapeutic;tool;transcriptomics;treatment strategy;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor stage;tumorigenesis;tumorigenic

PROJECT_TITLE: Uncovering the heterogenous role of senescence in prostate immune suppression and tumorigenesis

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Prevention;Rare Diseases

PHR: Project Narrative Liver fibrosis is the formation of scar tissue in the liver that is caused by chronic damage to the LIVER that can arise from a virus like hepatitis C virus, metabolic disorders like diabetes, or from alcohol or drug abuse, and the presence of liver fibrosis increases the risk of primary liver cancer. In this project we are developing molecular probes for use in MRI that can detect the total amount of fibrosis, that can detect fibrosis disease activity, and can detect fibrosis associated with inflammation. We will test whether using these probes with MRI can predict who will progress to liver cancer using animal models, and whether we can use imaging to select treatments that could prevent development of liver cancer.

PI_NAMEs: CARAVAN, PETER D (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Acute;Affinity;Alcohol abuse;Aldehydes;Amino Acids;Animal Model;Animals;antifibrotic treatment;Binding;Biochemical;chelation;Chemoprevention;Chemopreventive Agent;Choline Deficiency;Chronic;chronic liver disease;Cicatrix;Clinical;Collagen;Collagen Type I;Development;Diabetes Mellitus;Diethylnitrosamine;Disease;Disease Progression;Dose;Drug abuse;Early Diagnosis;efficacy evaluation;Erlotinib;Etiology;fibrogenesis;Fibrosis;Funding;Goals;Grant;Hepatic Fibrogenesis;Hepatitis C virus;High Fat Diet;high risk population;Histologic;Histopathology;Image;Inflammation;Injections;Kinetics;Libraries;Liver;liver development;Liver diseases;Liver Fibrosis;Magnetic Resonance;Magnetic Resonance Imaging;Malignant neoplasm of liver;Measures;Metabolic Diseases;Methods;Modeling;Molecular;Molecular Disease;molecular imaging;Molecular Probes;mortality;mouse model;Mus;nonalcoholic steatohepatitis;novel;outcome prediction;oxidation;Pathway interactions;Patients;Peptides;Peroxidases;Pre-Clinical Model;Prediction of Response to Therapy;prevent;preventive intervention;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;progression risk;quantitative imaging;Rattus;real time monitoring;response;Risk;risk prediction;Risk Reduction;Rodent Model;screening;Signal Transduction;Site;Specificity;Testing;Tissues;tool;Treatment Efficacy;Virus;Work

PROJECT_TITLE: Molecular Magnetic Resonance of Hepatic Fibrogenesis

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Childhood Injury;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: WASHINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The electroencephalogram (EEG) is an essential tool for diagnosis of neurological problems in newborn infants, yet we know little about the neural circuits that produce the EEG signal at this age. This project will explore the contribution of cortical and sub-cortical neuronal activity to the rapid developmental changes observed a validated animal model of EEG development. Our long-term objective is to apply knowledge gained from the animal model to the developing infant EEG to improve diagnosis of neonatal brain injury, allow more targeted treatments, and improve neurological outcome for infants at risk of brain injury.

PI_NAMEs: COLONNESE, MATTHEW TODD (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Ablation;Address;Age;age related;Animal Model;Area;Arousal;Atlases;Automobile Driving;Biological Assay;Birth;Brain;Brain Injuries;Cell Nucleus;Cells;Clinical;Cognition Disorders;cognitive disability;Compensation;Cre driver;critical period;density;Dependence;Development;Diagnosis;Diagnostic;diagnostic tool;Dorsal;Electroencephalography;Electrophysiology (science);Evaluation;experimental study;Eye;fetal;Future;gain of function;Generations;Genetic;genetic manipulation;Genetic Techniques;Gestational Age;Goals;Head;Human;human model;human old age (65+);Image;Imaging Techniques;improved;in vivo;Infant;infant outcome;inhibitory neuron;Injury;insight;Intellectual functioning disability;Interruption;Intervention;Knowledge;Lateral Geniculate Body;Lifelong disability;loss of function;Measures;Mediating;Modeling;Monitor;Mus;Neonatal;neonatal brain;Neonatal Brain Injury;neonatal human;neonatal mice;neonate;neural;neural circuit;Neurologic;Neurological outcome;Neurons;Newborn Infant;nonhuman primate;outcome prediction;Pattern;Periodicity;Population;Positioning Attribute;postnatal development;pre-clinical;Pre-Clinical Model;Preparation;Process;Publishing;Rattus;Recovery;Risk;Rodent;Role;Sensory;Side;Signal Transduction;Sleep;Thalamic Nuclei;Thalamic structure;Time;tool;transmission process;treatment response;Visual;Visual Cortex;Visual System;Work

PROJECT_TITLE: Thalamic contributions to the developing EEG

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Human Genome;Kidney Disease;Lupus;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative In individuals with systemic lupus erythematosus (SLE), a major complication that disproportionally affects children is the development of kidney inflammation, called lupus nephritis. Current lupus nephritis treatments are incompletely effective, leaving patients with this disease at increased long-term risk of kidney failure. We propose to use a new technology called spatial transcriptomics to study kidney tissue from children with lupus nephritis, with the rationale that improved understanding of underlying immune mechanisms will guide the development of new lupus nephritis treatments.

PI_NAMEs: JACKSON, SHAUN WILLIAM (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Academia;Acceleration;Adult;Affect;Age;Animal Model;Antigen-Antibody Complex;archived data;Archives;Atlases;Automobile Driving;biological adaptation to stress;Biology;Biopsy;Blinded;Blood capillaries;cell type;Cells;Child;Childhood;Chronic Disease;Clinical;clinical remission;Clinical Trials;Complement;Complication;cost effective;Cyclophosphamide;Data;data archive;Development;Diabetes Mellitus;Diagnostic;digital;Disease;Dissociation;Exclusion;Exhibits;expectation;Failure;Functional disorder;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic Transcription;Glomerulonephritis;Goals;Heterogeneity;high risk;Human;Human Biology;Hypertension;IGA Glomerulonephritis;imager;Immune;immune cell infiltrate;improved;Incidence;Individual;Industry;Inflammation;Inflammatory;insight;Kidney;kidney biopsy;kidney cell;Kidney Diseases;Kidney Failure;Knowledge;Lesion;Link;Lupus;Lupus Nephritis;Mediating;Medicine;Membranoproliferative Glomerulonephritis;Molecular;mycophenolate mofetil;nano-string;Neoadjuvant Therapy;nephrogenesis;new technology;new therapeutic target;novel therapeutics;Outcome;Pathogenesis;Pathologist;Pathology;Pathway interactions;patient population;Patients;Pediatric cohort;pediatric lupus;pediatric patients;podocyte;Population;preclinical study;Prediction of Response to Therapy;programs;protein expression;Protocols documentation;Publishing;Rare Diseases;renal damage;Research Personnel;Resolution;Resources;response;Risk;Sampling;Signal Pathway;single-cell RNA sequencing;Spatial Distribution;standard of care;Stochastic Processes;Systemic Lupus Erythematosus;targeted treatment;Testing;Therapeutic;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptomics;treatment response;Tubular formation;Validation

PROJECT_TITLE: Interrogating The Biology Of Human Lupus Nephritis Using Single Cell Resolution Spatial Transcriptomics

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Kidney Disease;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative IgA nephropathy is the most common primary glomerulonephritis in the world, with many patients progressing to kidney failure. We propose to define the factors that determine the pathogenic potential of circulating IgA1 immune complexes and affect disease progression in patients with IgA nephropathy. Results of the proposed experimental and clinical studies will guide the development of future therapies for IgA nephropathy and provide critical information for risk stratification of patients being considered for clinical trials. 1

PI_NAMEs: NOVAK, JAN  (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Address;Affect;Antigen-Antibody Complex;Binding;Biochemical;Biological;Cell Proliferation;Characteristics;Circulation;Clinical;clinical phenotype;Clinical Research;Clinical Trials;Complement;Complement 3b;Complement Factor H;Complex;cytokine;Data;Deposition;Development;Disease;disease model;Disease Progression;disorder control;Enzyme-Linked Immunosorbent Assay;Exhibits;experimental study;Funding;Future;Galactose;Genetic;Glomerulonephritis;Goals;Human;IGA Glomerulonephritis;IgA1;IgG autoantibodies;Immunodeficient Mouse;Immunoglobulin A;Immunoglobulin G;In Vitro;in vivo;in vivo Model;Injury to Kidney;innovation;Kidney Failure;Knowledge;Lupus Nephritis;Membranous Glomerulonephritis;mesangial cell;Modeling;Molecular;molecular mass;Molecular Sieve Chromatography;multidisciplinary;Pathogenesis;Pathogenicity;Pathology;patient stratification;Patients;Polymers;Polysaccharides;prevent;Process;Production;Progressive Disease;Proteins;Protocols documentation;Publishing;Recombinants;Research Personnel;risk stratification;Sampling;Serum;Sialic Acids;Signal Pathway;Signal Transduction;specific biomarkers;sulfated glycoprotein 2;Techniques;Testing;Western Blotting

PROJECT_TITLE: Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Estrogen;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Parkinson disease (PD) is a debilitating, fatal disease in which the protein alpha- synuclein (S) accumulates in all cases, and S mutations cause familial forms of PD. Here we propose extending our findings of female sex and brain estradiol that partly preserved the soluble S tetramer-monomer homeostasis and aided against the rapid PD-like motor syndrome, including resting tremor, gait and cognitive deficits. We will thoroughly investigate estrogen mechanisms that reduced protein aggregates by elevating estradiol or increasing synaptic estrogen receptors in different PD and Gaucher’s PD model mice with a view to developing new understanding and therapies.

PI_NAMEs: NUBER, SILKE  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: 3-Dimensional;Age;Age of Onset;alpha synuclein;Basic Science;Biochemical;Biological;Bradykinesia;Brain;Cells;Chronic;Clinical;Cognition;Cognitive deficits;combat;Data;Dementia with Lewy Bodies;Dependence;Development;Disease;early onset;effectiveness evaluation;Electrophysiology (science);Equilibrium;ESR1 gene;Estradiol;Estrogen Nuclear Receptor;Estrogen Receptors;Estrogens;experimental study;Female;Fiber;Foundations;Functional disorder;Gait;Generations;Genetic Models;genetic risk factor;Genetic Transcription;Goals;Grant;Health;Histopathology;Homeostasis;Impaired cognition;improved;in vivo;Individual;inhibitor;Lipids;loss of function mutation;male;Measurement;Membrane;Mental Depression;monomer;Motor;motor deficit;motor impairment;motor symptom;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;National Institute of Neurological Disorders and Stroke;neuropathology;neuroprotection;novel;novel therapeutic intervention;novel therapeutics;Nuclear;palmitoylation;Parkinson Disease;Pathologic;Pathway interactions;Phenotype;Physiological;premature;preservation;prevent;Prevention trial;Prodrugs;Progress Reports;protein aggregation;Proteins;Publishing;Quality of life;rational design;Recombinants;Reporting;Resistance;Rest Tremor;Risk;Risk Factors;Role;Severities;sex;Sex Differences;sexual dimorphism;small molecule inhibitor;sporadic Parkinson's Disease;Synapses;synaptic function;Synaptic Membranes;Synaptic Vesicles;Syndrome;synucleinopathy;Testing;Therapeutic Trials;Time;Tremor;Vesicle;women versus men;Work

PROJECT_TITLE: Biologically Novel Mouse Models of PD with Progressive Synucleinopathy and Early-Onset Tremor and Motor Deficits Responsive to L-DOPA

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Emergency Care;Neurosciences;Patient Safety

PHR: Project Narrative Although MRI scanners are very effective at evaluating brain disease and injury, their large size, specialized siting constraints, and high cost limit their impact by limiting their use to occasional diagnostic examinations. Our goal is to develop a novel, simplified MRI “brain monitor”; an MRI scanner whose entire weight is less than 10kg and can reach into the patient's bed and monitor a patient's brain continuously.

PI_NAMEs: WALD, LAWRENCE L (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Abscess;Accident and Emergency department;Acoustics;Ambulances;arm;Articulation;Beds;Brain;Brain Diseases;Brain Edema;Brain Injuries;brain magnetic resonance imaging;Brain region;Caring;Cerebral Edema;Cerebral Infarction;Cerebrum;Clinical;cost;design;Detection;detection platform;detector;Development;Devices;Diagnosis;Diagnostic;Diagnostic Equipment;Diameter;Diffusion;Edema;Emergency Care;Encephalomalacia;Environment;FDA approved;Geometry;Goals;Head;Height;Helmet;Hemorrhage;Hockey;Hour;Image;Imaging Device;Intensive Care Units;Intracranial Hemorrhages;Intracranial Hypertension;Intracranial Pressure;Life;light weight;Location;magnetic field;Magnetic Resonance Imaging;Maintenance;Malignant - descriptor;Methods;Monitor;Nervous System Disorder;Nervous System Trauma;Neurologic;Noise;novel;novel strategies;Obstruction;Operative Surgical Procedures;Pathology;Patient Monitoring;patient monitoring device;Patients;Pharmaceutical Preparations;Physiologic pulse;point of care;portability;power consumption;programs;prototype;Relaxation;Resolution;RF coil;rural healthcare;Shapes;Site;Sports;standard of care;stroke patient;Structure;Subdural Hematoma;System;Technology;temporal measurement;Testing;Time;Transducers;Trauma;ventilation;Ventricular;Visualization;Weight;Work

PROJECT_TITLE: Technology for MR brain monitoring

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]