ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Patient Safety;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE This study aims to identify a pregabalin/lofexidine combination that decreases the dysphoria and other subjective effects of opioid withdrawal and increases the proportionof patients that makethe transitionfrom opioid addiction to antagonist treatment with its overdose prevention and other beneficial effects.

PI_NAMEs: KAMPMAN, KYLE MATTHEW (contact);WOODY, GEORGE EDWARD

PROGRAM_OFFICER_NAME: DRGONOVA, JANA

PROJECT_TERMS: addiction;Adrenergic Agonists;Adrenergic alpha-Agonists;Adult;Adverse event;Affect;Agonist;Analgesics;antagonist;Anxiety;Buprenorphine;Calcium;Caring;Clinical;Clonidine;Consent;craving;Data;Decarboxylation;Dose;Double-Blind Method;Drug Metabolic Detoxication;dysphoria;Enrollment;Enzymes;Europe;Excretory function;FDA approved;Fibromyalgia;gamma-Aminobutyric Acid;Glutamate Decarboxylase;Goals;Half-Life;Health;Heroin;Hour;Hypotensives;improved;improved outcome;Individual;Injectable;Inpatients;interest;Kidney;Liver;lofexidine;Maintenance;Mental Depression;Metabolism;Methadone;Methods;Naltrexone;Neurotransmitters;non-opioid analgesic;Opiate Addiction;Opioid;opioid use disorder;opioid withdrawal;Outcome;Outpatients;Overdose;overdose prevention;Overdose reduction;overdose risk;painful neuropathy;Paper;Participant;Patient Preferences;Patients;Persons;Pharmaceutical Preparations;Phase;Placebos;Plasma;pregabalin;primary outcome;Product Packaging;Property;Protocols documentation;Publications;Randomized;Receptors, Adrenergic, alpha-2;Recommendation;Regimen;Relapse;Reporting;Resources;Running;Russia;Schedule;secondary outcome;Sedation procedure;Seizures;Serious Adverse Event;Severities;Sleeplessness;Slow-Wave Sleep;success;Survival Analysis;Symptoms;Testing;Time;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Combining Pregabalin with Lofexidine: Can it Increase the Success of Transition to Naltrexone?


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biotechnology;Chronic Pain;Nutrition;Obesity;Osteoarthritis;Pain Research;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ORTHOPEDICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Fat, or adipose tissue, is a source of systemic inflammation involved in the pathogenesis of osteoarthritis (OA), but the manner in which this occurs, and the factors involved, remain unclear. The goal of this revised proposal is to develop a platform to interchangeably and specifically delete signaling factors from fat to uncover the mechanism of adipose-cartilage signaling. Using this novel and flexible platform, we will hijack fat signaling to deliver anti-inflammatory mediators in a tunable and well-controlled manner, which will serve as the basis for a novel regenerative therapy for OA, and the basis for a niche line of inquiry in adipose-cartilage signaling from which Dr. Collins can build an independent research program.

PI_NAMEs: COLLINS, KELSEY HELEN-MARIE (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Address;Adipocytes;adipokines;Adipose tissue;Affect;aggrecan;Animals;Anti-Inflammatory Agents;Area;Bioinformatics;Biological;Biomechanics;Biomedical Engineering;Body fat;Cardiovascular Diseases;career;Cartilage;Cell Differentiation process;Cell Line;cell type;Cells;Chondrocytes;Chronic Disease;Clinical;combat;Complement Factor D;Complex;Consumption;CRISPR/Cas technology;Degenerative polyarthritis;design;Development;Diabetes Mellitus;disability;Disease;Engineering;Fatty acid glycerol esters;flexibility;Future;Gene Deletion;Generations;Genetic Transcription;genome editing;Genome engineering;Goals;Grant;Health;High Fat Diet;Homeostasis;Hormones;Implant;implantation;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inflammation;Inflammation Mediators;Inflammatory;Injury;Insulin Resistance;interest;Interleukin-10;joint destruction;Joints;Knee Injuries;Knee joint;Knock-out;Lead;Leptin;Link;Lipodystrophy;Malignant Neoplasms;Mediator;Mentors;Metabolic;Metabolic syndrome;Monoclonal Antibodies;mouse model;Mus;Muscle Weakness;novel;novel strategies;Obesity;Oils;Operative Surgical Procedures;Pain;Pathogenesis;Pathologic;patient population;Pharmaceutical Preparations;Play;Positioning Attribute;Predisposition;programs;promoter;protective effect;Proteomics;Regenerative Medicine;regenerative therapy;Reporting;Research;Research Personnel;resistin;response;Role;Satiation;Signal Transduction;Source;Stains;subchondral bone;synthetic biology;systemic inflammatory response;Testing;Therapeutic;Time;tool;Training;transcriptome sequencing;Transgenic Mice;translational therapeutics;Transplantation;Traumatic Arthropathy

PROJECT_TITLE: The Role of Fat in Osteoarthritis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: CLEVELAND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Although many studies have found a correlation between cytokine treatment and resolution of pneumonia, cytokine therapy for pneumonia has been proven to be a long, hard slog because the biggest drawback of cytokine therapy is lack of specificity when it's given systemically. The goal of this proposal is to determine the consequence of cytokine-driven, cell-specific immunological and metabolic responses to pulmonary infection with established animal models. It is expected that the proposed studies will therefore be used to guide cytokine- based immunotherapy, potentially providing new immunometabolism-targeted therapeutic approaches for the treatment of pulmonary infections.

PI_NAMEs: LIU, XIN  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acetates;Acetyl Coenzyme A;Address;aerobic glycolysis;Animal Model;Anti-Bacterial Agents;Antibiotic Therapy;ATP Citrate (pro-S)-Lyase;Bacteria;Bacterial Infections;Bacterial Pneumonia;blood glucose regulation;Cause of Death;Cell Differentiation process;Cell Physiology;Cells;Communities;conditional knockout;cytokine;cytokine therapy;Data;Death Rate;Dendritic Cells;Development;enhancing factor;Enzymes;Epigenetic Process;Exhibits;glucose metabolism;Glycolysis;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Histone Acetylation;histone acetyltransferase;Homeostasis;Host Defense;Immunocompromised Host;Immunologics;Immunotherapy;in vivo;Infection;Infection Control;Inflammatory;insight;ITGAM gene;Knockout Mice;Knowledge;lactate dehydrogenase A;Legionella pneumophila;Legionnaires' Disease;loss of function;Lung infections;lung pathogen;Maintenance;Mediating;Metabolic;Metabolic Control;Metabolism;Mitochondria;monocyte;Mus;Myeloid Cells;Nosocomial pneumonia;Persons;Play;Pneumonia;pneumonia treatment;Production;Pulmonary Inflammation;reconstitution;Regulation;Resolution;Respiration;response;restoration;Role;Signal Transduction;Source;Specificity;targeted treatment;Testing;Tissues

PROJECT_TITLE: Mechanisms of GM-CSF-mediated metabolic regulation of monocyte function for control of pulmonary infection


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infertility;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: SEATTLE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The presence of aneuploidy (chromosomal abnormalities) in embryos is considered one of the major limitations to successful human reproduction and a significant cause of gestation failure, accounting for approximately 50% of early miscarriages. Despite the high incidence of aneuploidy in human embryos, our knowledge of the developmental fate of these cells and the involved molecular is restricted due to the considerable ethical limitations associated with human embryo and fetal research. The proposed study aims to establish a comprehensive marmoset model to examine aneuploidy cell fate and the putative elimination mechanism accompanying mosaicism during embryonic development, with the ultimate goal of providing the knowledge necessary for improving pregnancy success.

PI_NAMEs: YANG, MIN  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Accounting;Aneuploid Cells;Aneuploidy;aneuploidy analysis;Animal Model;Animals;Apoptosis;Apoptotic;Area;Assisted Reproductive Technology;Award;Behavior;Biological Assay;Birth;blastocyst;BMP4;Callithrix;Callithrix jacchus jacchus;career development;Career Mobility;CASP3 gene;Cattle;CDX2 gene;Cell Culture System;Cell Line;Cell Physiology;Cells;Cellular biology;Chromosomal Instability;Chromosome abnormality;chromosome number abnormality;Chromosomes;Clinic;clinical practice;Competence;Data;Defect;Development;Developmental Biology;Diagnostic tests;Embryo;Embryo Research;embryo tissue;Embryonic Development;embryonic stem cell;Ethics;Exhibits;experimental study;Failure;Fertilization in Vitro;Fetal Development;Fetal Research;Fluorescence;gastrulation;GATA3 gene;Gene Expression Profile;Gene Expression Profiling;Genes;genetic technology;Genomics;Geometry;Goals;Human;human embryonic stem cell;Image;implantation;improved;In Vitro;in vivo;Incidence;Knowledge;Maintenance;matrigel;migration;Modeling;Molecular;Molecular Biology;Morula;mosaic;Mosaicism;natural Blastocyst Implantation;Nature;nonhuman primate;Organoids;Pattern;Phase;Phenotype;Placenta;Placentation;Postnidation Embryo Development;preference;Pregnancy;Primates;Proliferating;Reproduction;Reproductive Biology;Reproductive Sciences;Reproductive Technology;Research;Research Personnel;response;Rodent;Rodent Model;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;SOX17 gene;Specific qualifier value;Spontaneous abortion;stem cell biology;stem cell model;stem cells;Study models;success;System;Techniques;Technology;Testing;Tissues;TP53 gene;Training;transcriptome;translational applications;trophoblast;Up-Regulation;Work

PROJECT_TITLE: Characterization of aneuploidy, cell fate and mosaicism in early development


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Narrative  The proposed randomized, controlled trial will evaluate the effects of an intervention to reduce exposure to medications among hospitalized older Veterans discharged to skilled nursing facilities (SNFs). The goal of the intervention is to safely deprescribe medications, as defined by dose reductions and discontinued medications, based on a combination of clinical criteria and patient preferences. We will evaluate the effects of the intervention on the total number of medications prescribed to Veterans at hospital and SNF discharge and at home 90-days after SNF discharge along with the prevalence of eight geriatric syndromes, medication adherence, and functional health status.

PI_NAMEs: MIXON, AMANDA SALANITRO (contact);SIMMONS, SANDRA F

PROJECT_TERMS: acute care;Adoption;Adverse drug event;Adverse event;Anti-Cholinergics;Award;beneficiary;Body Weight decreased;care providers;care systems;Caring;Clinical;Communities;cost;Data;Delirium;Development;Dose;Drug Prescriptions;Effectiveness;Effectiveness of Interventions;effectiveness/implementation design;Elderly;Exposure to;falls;follow-up;Funding;Future;Goals;Health;Health care facility;health care service utilization;health care settings;Health Status;Healthcare;high risk population;Home;Hospitalization;Hospitals;Hybrids;Impaired cognition;implementation intervention;improved;indexing;innovation;Intervention;intervention effect;Low Prevalence;Measures;Medicare;medication compliance;Methods;Monitor;multi-component intervention;older adult;older patient;Older Population;Outcome;Patient Discharge;patient engagement;patient oriented;patient population;Patient Preferences;patient safety;patient-level barriers;Patients;Pharmaceutical Preparations;pilot test;Polypharmacy;poor health outcome;Population;preference;Prevalence;primary outcome;prospective;Provider;provider-level barriers;Publishing;Randomized, Controlled Trials;Research Design;Safety;screening;secondary outcome;sedative;Severities;Skilled Nursing Facilities;Standardization;Syndrome;System;United States Centers for Medicare and Medicaid Services;uptake;Urinary Incontinence;Veterans

PROJECT_TITLE: Drug Reduction in Older Patients: The DROP Trial

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Data Science;Emergency Care;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE The long-term goal of our research is to develop an automated system to identify and mitigate adverse safety events in the out-of-hospital care of pediatric cardiac arrest. We will create a computerized tool using rules- and regression-based models, as well as both ontology-driven and neural NLP techniques, to identify adverse safety events from Emergency Medical Services clinical charts of pediatric out-of-hospital cardiac arrest and prospectively demonstrate the scalability of this automated screening system on two statewide samples of children with out-of-hospital cardiac arrest to understand and describe the incidence of and contributors to preventable adverse safety events.

PI_NAMEs: GUISE, JEANNE-MARIE  (contact)

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Academy;Adult;Adverse event;Algorithms;American;American Heart Association;Automated Annotation;care systems;Caring;Cessation of life;Child;Child Care;Child Health;Child health care;Childhood;Clinical;Collection;Complex;computerized tools;Computing Methodologies;cost;Data;Data Set;data visualization;deep learning;Detection;Development;effective therapy;Electronics;Elements;Emergency Care;Emergency medical service;Emergency Situation;Encapsulated;Environment;Epidemiology;Evaluation;Event;evidence base;experience;Future;Goals;Guidelines;Health;health care delivery;Healthcare Systems;Heart Arrest;high risk;hospital care;Hospitals;improved;Incidence;Informatics;Information Systems;Infrastructure;Injury;Interdisciplinary Study;Knowledge;Learning;Life;Logic;Machine Learning;Manuals;Medical;Medical Errors;Medicine;Methods;Modeling;Modernization;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Natural Language Processing;neural;novel;Ontology;Oregon;out-of-hospital cardiac arrest;Outcome;Output;patient safety;pediatric emergency;Pediatric Hospitals;pediatric patients;Play;point of care;Population;Pre-hospitalization care;prevent;Procedures;prospective;Provider;Quality of Care;Recommendation;Records;Research;Research Personnel;Role;Safety;Sampling;Scientist;screening;Secure;sequence learning;service providers;Structure;structured data;Supervision;Survival Rate;System;Techniques;Testing;Text;tool;Transcend;trauma care;United States;Utah;Visualization software;Work

PROJECT_TITLE: Using Machine Learning to find a life saving needle in a haystack of children's emergencies

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases;Microbiome

ORG_CITY: NEW YORK

ORG_DEPT: DENTISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative In this application, we propose to investigate the novel FadA adhesin from oral bacterium Fusobacterium nucleatum, which has been implicated in a wide spectrum of human diseases, including periodontal disease, adverse pregnancy outcomes and colorectal cancer. FadA is an essential virulence factor of F. nucleatum playing a pivotal role in the disease processes. Our study will help identify therapeutic targets for prevention and treatment of a series of human diseases within and beyond the oral cavity. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page

PI_NAMEs: HAN, YIPING  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: adverse pregnancy outcome;Alveolar Bone Loss;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloid Fibrils;Anaerobic Bacteria;Antibodies;Bacteria;Bacterial Adhesins;Binding;Biochemical;biofilm species;cadherin 5;cancer cell;Carcinoma;Cell surface;Cells;Colorectal Cancer;Communities;Complex;Congo Red;cytokine;Data;Detergents;Disease;Dyes;E-Cadherin;Endothelial Cells;Epithelial Cells;Exhibits;Fusobacterium;Fusobacterium nucleatum;Genetic;Gingiva;Growth;Human;human disease;In Vitro;in vivo;Infection;Inflammatory;Inflammatory Response;interdisciplinary approach;Invaded;Investigation;Laboratories;Large Intestine Carcinoma;Light;Malignant neoplasm of gastrointestinal tract;medical attention;Microbial Biofilms;Modeling;Molecular;mouth squamous cell carcinoma;Mus;mutant;Non-Insulin-Dependent Diabetes Mellitus;novel;opportunistic pathogen;Oral;oral bacteria;Oral cavity;oral cavity epithelium;oral commensal;Organism;pathogen;Pathogenesis;Pathogenicity;Peptides;Periodontal Diseases;Periodontal Infection;Periodontal Pocket;Periodontitis;periodontopathogen;Phase;Placenta;Play;Pregnancy Complications;Prevention;Process;Production;Property;protein aggregation;Proteins;Reaction;Recombinants;Regulation;Research;Resistance;Resolution;response;Role;scaffold;Series;Site;Structure;Therapeutic;therapeutic target;Virulence;Virulence Factors

PROJECT_TITLE: Investigation of FadA adhesin from Fusobacterium nucleatum

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Muscular Dystrophy;Orphan Drug;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  Mutations that prematurely halt protein synthesis cause 11% of all heritable human diseases. This proposal seeks to dissect how the concluding stages of protein synthesis are regulated on proper (non- mutated) transcripts, and further examine the closely-related processes that ensure the destruction of aberrant (e.g. mutated) transcripts. In addition to illuminating basic mechanisms of cellular life, the proposed work will support the development of novel therapeutics for diseases such as Cystic Fibrosis, Breast-Ovarian Cancer, and Duchenne Muscular Dystrophy.

PI_NAMEs: LAWSON, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affect;Architecture;ATP phosphohydrolase;Award;Biological Assay;Breast;CRISPR screen;Cryoelectron Microscopy;Cystic Fibrosis;Development;Disease;Duchenne muscular dystrophy;Ensure;Eukaryota;Eukaryotic Cell;Event;Foundations;Future;Gene Expression;genome-wide;Health;Hereditary Neoplastic Syndromes;Heritability;Human;human disease;In Vitro;Individual;inhibitor;Kinetics;Language;Learning;Life;Malignant neoplasm of ovary;Malignant Neoplasms;Mentors;Messenger RNA;Molecular;Monitor;mRNA Decay;Muscular Dystrophies;Mutate;Mutation;Non-Stop Decay;Nonsense Codon;novel therapeutics;Open Reading Frames;Outcome;Pathway interactions;peptidyl-tRNA;Phase;polypeptide;Postdoctoral Fellow;premature;Process;programs;Protein Biosynthesis;Proteins;reconstitution;Recycling;Regulation;Research;Research Activity;ribosome profiling;Ribosomes;Signal Transduction;single molecule;skills;Specificity;Structural Biologist;Structure;System;Techniques;Terminator Codon;Testing;Therapeutic;Time;time use;Training;Training Activity;Transcript;Transfer RNA;Translating;translation factor;Translations;Work;Yeasts

PROJECT_TITLE: Dynamic interplay of eukaryotic translation and mRNA decay


ADMINISTERING_IC: NR

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

ORG_CITY: BAINBRIDGE ISLAND

ORG_NAME: COVE TECHNOLOGY CONSULTING LLC

PHR: Project Narrative IV pumps are the gold standard for infusion, but they cannot meet all infusion needs, hence gravity IV infusion continues to be ubiquitous in healthcare. However, there is much room for improvement in gravity infusions, which can result in inaccurate medication administration and adverse effects for patients. In this SBIR project, Shift Labs proposes a game-changing inexpensive, battery-powered device that uses novel sensor technology and algorithms to accurately monitor and control gravity infusions. This will result in a safe, cost-effective device that allows patients to receive best-in-class care in a wide range of healthcare settings, including their homes and surge settings.

PI_NAMEs: KAWAHARA, CHIE  (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: 3-Dimensional;Accounting;active control;Acute;Adoption;Adverse effects;algorithm development;Algorithms;analog;Back;Caring;Clinical;clinical practice;Clip;Complex;computerized data processing;cost;cost effective;Coupled;Data;design;Detection;Development;Devices;digital;Drops;Electronics;Engineering;Environment;Evaluation;experience;experimental study;falls;Feedback;Force of Gravity;Generations;Goals;health care delivery;Health care facility;health care settings;Health Personnel;Health Services Accessibility;Healthcare;Healthcare Market;Home;Hospitals;Immunocompromised Host;improved;in silico;Infrastructure;Infusion procedures;Infusion Pumps;innovation;Inpatients;instrumentation;Interruption;Intervention;Intravenous;Intravenous infusion procedures;large datasets;Light;light transmission;Liquid substance;Long-Term Care;machine learning method;Manuals;Measures;Medical Device;medication administration;Medicine;Methods;Monitor;Motor;new technology;novel;Nurses;Optics;Output;pathogen exposure;Patients;Performance;Periodicals;Pharmaceutical Preparations;Phase;preclinical development;Procedures;Process;prototype;Pump;Recording of previous events;Regulatory Pathway;Research;Resources;sensor;sensor technology;Signal Transduction;Site;Small Business Innovation Research Grant;Statistical Data Interpretation;System;Systems Integration;Technology;Testing;Time;Transportation of Patients;trend;Tube;usability;Validation;Viscosity;Work

PROJECT_TITLE: A closed-loop gravity infusion control device


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health

ORG_CITY: FARMINGTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Narrative HIV/AIDS is a global epidemic affecting ~37.9 million people. HIV viral load testing plays a crucial role in HIV patients undergoing therapy, early diagnosis of acute HIV infection, as well as infants born to infected mothers. The objective of this project is to develop a simple, rapid, affordable, CRISPR biosensing platform for HIV viral load self-testing.

PI_NAMEs: LIU, CHANGCHUN  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acute;Adopted;Affect;antiretroviral therapy;Bioinformatics;Biological Assay;biomaterial compatibility;Biosensing Techniques;Blinded;Blood;Blood capillaries;Blood specimen;Cellular Phone;Clinical;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;cost;Country;Cytolysis;Data;design;Detection;detection platform;detection sensitivity;Developing Countries;Development;Devices;diagnostic technologies;diagnostic tool;Early Diagnosis;Early Intervention;Engineering;Ensure;Environment;Epidemic;Equipment;Evaluation;field study;Fingers;Fluorescence;Health;HIV;HIV diagnosis;HIV Infections;HIV-1;HIV/AIDS;Home;Hospitals;Human immunodeficiency virus test;Human Resources;Immunoassay;improved;Individual;Infant;Infectious Diseases Research;innovation;instrument;instrumentation;internal control;International;isothermal amplification;Laboratories;Membrane;Methods;Microfluidic Microchips;molecular diagnostics;Monitor;Mothers;multidisciplinary;next generation;Nucleic Acid Amplification Tests;Nucleic Acids;Patients;Pennsylvania;Performance;Persons;Phase;Plasma;Play;point of care;point-of-care detection;point-of-care diagnostics;Polymerase;portability;Public Health;Reaction;recombinase;Recovery;Reporting;Research;Resource-limited setting;Reverse Transcriptase Polymerase Chain Reaction;Reverse Transcription;Risk;RNA;Role;Sampling;self testing;seroconversion;Signal Transduction;Specificity;Statistical Data Interpretation;System;Technology;Test Result;Testing;tool;Training;transmission process;Treatment Effectiveness;Treatment Failure;Universities;Validation;Viral;viral detection;Viral Load result;viral rebound;viral RNA;Viremia;Virus;Whole Blood;Zambia

PROJECT_TITLE: Self-Powered Sample Concentrating and CRISPR-based Biosensing for Moile HIV-1 RNA Detection


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: WINCHESTER

ORG_NAME: HOPEFUL AGING LLC

PHR: PROJECT NARRATIVE An estimated 6.2 million Americans are currently suffering from Alzheimer's disease (AD); besides affecting the person with the condition, AD also presents a public health concern, due to the significant cost required to care for persons with dementia (PWD) and to the mental and physical stress placed upon caregivers. So, there is an urgent need for products and programs that improve the quality of life of PWD and reduce Behavioral Expressions. Additionally, the long term care industry is regularly afflicted by staffing shortages leading to reduced quality of care for PWD. Through the development and evaluation of an app that enables retired senior volunteers to lead a personalized music and discussion intervention with persons with dementia, the proposed project will help meet this need.

PI_NAMEs: GORZELLE, GREGG  (contact);ORSULIC-JERAS, SILVIA

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: acceptability and feasibility;Adherence;Affect;Aggressive behavior;Aging;Agitation;Alzheimer's Disease;American;Anxiety;Area;Behavioral;Blinded;caregiver education;Caregivers;Caring;Chronic Disease;Collaborations;Communication;Community Healthcare;cost;Creativeness;Data;Dementia;design;Development;E-learning;Educational Curriculum;Elements;Evaluation;evidence base;experience;Feedback;Focus Groups;Funding;Health;Health care facility;Healthcare;Healthcare Systems;human old age (65+);improved;Industry;Institution;Intervention;Light;Long-Term Care;Love;Marketing;member;Mental Depression;Music;Music Therapy;older adult;online version;Paper;Patient Self-Report;Persons;Phase;Pilot Projects;Principal Investigator;programs;Protocols documentation;prototype;Psyche structure;psychosocial;Public Health;Quality of Care;Quality of life;Research;Role;satisfaction;Site;Small Business Technology Transfer Research;software development;Stress;Structure;Tablets;Testing;Time;Training;Training Activity;United States;Use Effectiveness;volunteer;Work

PROJECT_TITLE: Making Connections Thru Music: A Group Music Therapy-Based Intervention for Persons with Dementia


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma (PDA) is a highly aggressive and lethal disease with an average five-year survival rate of 9%, in part due to its late detection and profound resistance to current therapies. I continue to develop more effective and novel mouse models of PDA that will enable us to study the functions of targetable genes and pathways in vivo, and help to understand the identities and functions of diverse cell types observed in human PDA. I will use these findings to design novel therapeutic strategies to eradicate both cancer cells and tumor-promoting non-cancerous fibroblasts simultaneously.

PI_NAMEs: PARK, YOUNGKYU  (contact)

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: Ablation;antagonist;Antibodies;Antigen Presentation;Automobile Driving;cancer cell;Cancer Model;cancer type;Candidate Disease Gene;cell type;Cells;Data Set;design;Desmoplastic;Detection;Development;Disease;efficacy testing;Endothelial Cells;Engraftment;Extracellular Matrix;Fibroblasts;Frequencies;Genes;Genetically Engineered Mouse;Heterogeneity;Homeostasis;Human;IL1R1 gene;Immune;Immunotherapy;improved;in vivo;Inflammatory;inhibitor;KRAS oncogenesis;KRAS2 gene;LIF gene;Malignant Neoplasms;Mitochondria;Modeling;mouse model;Mus;Mutation;new therapeutic target;novel;novel therapeutic intervention;Oncogenes;organoid transplantation;Organoids;Oxidation-Reduction;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;Population;Pre-Clinical Model;preclinical development;Proteomics;Reporting;Research;Resistance;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;standard of care;Survival Rate;targeted treatment;Testing;Therapeutic;therapeutic development;transcriptomics;tumor ablation;tumor growth;tumor microenvironment;Tumor Promotion;Viral;Work

PROJECT_TITLE: Preclinical Models for Cancer Therapeutic Development


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Human Genome;Mental Health;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE To advance our knowledge of the cardiovascular, metabolic, and psychological health of Asian Americans, Native Hawaiians and Pacific Islanders (AsA-NHPI), we will recruit a population-based cohort of several distinct AsA-NHPI populations from 4-6 Clinical or Community Field Centers and assess a wide range of risk factors and health outcomes using rigorous, culturally appropriate methods. Our diverse team of investigators has deep expertise in cardiovascular and nutritional epidemiology, biostatistics, medicine, immigrant health, behavioral science, geospatial methods, mobile health, laboratory science, and genomics, as well as extensive experience coordinating the activities of large, multi-center prospective cohort studies to contribute to and enhance this effort. This cohort will also serve as a platform for numerous additional ancillary studies that will further address the health concerns of AsA-NHPI individuals.

PI_NAMEs: ANDERSON, GARNET L. (contact);CHAN, KWUN CHUEN GARY ;FLOYD, JAMES S;KAPLAN, ROBERT C

PROGRAM_OFFICER_NAME: SANTOS, STEPHANIE

PROJECT_TERMS: Address;Ancillary Study;Asian;Asian Americans;Asian population;Behavioral Sciences;biobank;Biological;Biometry;Brain imaging;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular risk factor;Cardiovascular system;career development;climate change;Clinical;cohort;Communities;community engagement;Data;Data Collection;Data Linkages;Data Science;Data Sources;Environment;epidemiology study;Etiology;experience;Funding;Generations;Genetic;Genomics;Goals;Hawaiian;Hawaiian population;Health;heart imaging;Heterogeneity;Immigrant;Immigration;Individual;Infrastructure;insight;International;Knowledge;Laboratories;Leadership;Learning;Life Style;Medicine;Mental disorders;Mental Health;Mentors;Metabolic;Metabolic Diseases;metabolomics;Methods;mHealth;microbiome;Minority;National origin;Native Hawaiian or Other Pacific Islander;Neighborhoods;next generation;novel;nutritional epidemiology;Outcome;Pacific Islander;Pacific Islands;Physical assessment;physical conditioning;Population;population based;Prevalence;programs;prospective;Prospective, cohort study;Proteomics;recruit;Research;Research Personnel;Resources;Risk Factors;Science;social health determinants;Sociology;Source;Stereotyping;Stress;Time;United States National Institutes of Health;wearable device

PROJECT_TITLE: Hawaiian, Asian American, and Pacific Islander (HAAPI) Coordinating Center


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric;Serious Mental Illness

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Executive dysfunction is a transdiagnostic feature of mental illness that emerges in youth and is associated with disease severity. The findings of this study will significantly advance our understanding of the mechanisms that underlie executive dysfunction, paving the way for targeted treatments and interventions. These advancements will benefit public health and reduce the burden of executive dysfunction on society by improving outcomes for individuals with mental illness.

PI_NAMEs: LARSEN, BART  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Adolescence;Adolescent;Affect;Age;Age Months;age related;aged;Attention deficit hyperactivity disorder;Automobile Driving;Award;Basal Ganglia;Biometry;Blood;Blood Tests;brain abnormalities;brain iron;Brain Mapping;Characteristics;Child;Childhood;Clinical;clinically relevant;Cognitive;cognitive process;cognitive testing;cohort;Communities;Corpus striatum structure;Data;data resource;Data Set;Development;Diagnostic;early adolescence;early childhood;Executive Dysfunction;executive function;Female;Foundations;Functional Magnetic Resonance Imaging;Goals;Gur;Hemoglobin;Image;improved;improved outcome;Individual;Individual Differences;Intervention;Iron;iron deficiency;Laboratories;Life;Link;Magnetic Resonance Imaging;male;Maps;Mediating;Medical Records;Mental disorders;Mentorship;Modeling;MRI Scans;neurobiological mechanism;neuroimaging;neuropsychiatry;neurotransmission;Nutrient;Outcome;Pathologic;Pathway interactions;Pennsylvania;Peripheral;Phase;Philadelphia;Physiology;Predisposition;Prevalence;programs;prospective;Psychoses;Puberty;Public Health;Recording of previous events;recruit;Research;Resolution;response;routine screening;Sampling;screening;screening guidelines;Severity of illness;Sex Differences;Short-Term Memory;Societies;Source;statistics;Symptoms;T2 weighted imaging;Testing;Time;Training;translational model;University resources;Work;Youth

PROJECT_TITLE: Brain iron as a neurodevelopmental mechanism for transdianostic executive dysfunction


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Mendelian variation in pigmentation is a rich genetic resource to understand signaling pathways relevant to human biology and has led to the identification of a novel transmembrane protease, Transmembrane aminopeptidase Q/Laeverin (Taqpep/LVRN), involved in biology of the placenta, hair, palate, and gut. This application uses pigmentary variation in animals to discover new genes that interact with Taqpep, and to better understand Taqpep function by studying knockout mice.

PI_NAMEs: BARSH, GREGORY STEFAN (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Admixture;Affect;Aminopeptidase;Animals;Area;Asian;Biological Process;Black Panther;Breeding;Candidate Disease Gene;causal variant;Cell Culture Techniques;cell type;Characteristics;Cheetahs;Color;Communities;Darkness;Development;DNA;Domestic Animals;Enteric Nervous System;Exhibits;Experimental Genetics;experimental study;Family Felidae;Felis catus;fetal;forward genetics;gene discovery;gene interaction;Genes;Genetic;genetic approach;genetic association;genetic pedigree;genetic resource;Genetic study;genetic variant;genome sequencing;genome wide association study;Hair;Hair Color;Heritability;Human;Human Biology;human disease;Individual;inhibitor;insight;Investigation;Knockout Mice;Laboratory mice;Laboratory Study;loss of function;Mammalian Cell;Mammals;Marble;Melanogenesis;Membrane;model organism;Molecular;Morphology;mouse genetics;Mus;Mutant Strains Mice;Mutation;Names;novel;Organism;Palate;Pathway interactions;Pattern;Peptide Hydrolases;Phenotype;Pigmentation physiologic function;Placental Biology;Placentation;Population;Proteomics;Research;Role;Rwanda;Sampling;self organization;Signal Pathway;Signal Transduction;Skin;Spottings;System;Technology;Testing;Tigers;Tissue Sample;Tissues;trait;transcriptomics;Variant;whole genome;Wild Animals;WNT Signaling Pathway;Work;Zebra

PROJECT_TITLE: Genetic studies of a pleiotropic transmembrane protease: insight from color variation in non-model organisms

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Women are disproportionately affected by Alzheimer’s disease, and there are well-documented—but poorly understood—sex differences in disease progression and response to therapeutics. Insights into the mechanisms underlying these sex differences will allow us to better treat AD, and improve individualized approaches to disease intervention. The work proposed here will utilize powerful mouse models of AD and rich, multilevel human datasets to identify genes and pathways that robustly regulate sex differences in the symptoms and response to treatment in AD.

PI_NAMEs: HARARI, OSCAR ;HOHMAN, TIMOTHY J;KACZOROWSKI, CATHERINE COOK (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease risk;Alzheimer's disease therapeutic;Apolipoprotein E;Atlases;Behavioral;behavioral phenotyping;bioinformatics tool;Biological;Biological Models;Brain;Brain region;candidate validation;cell type;Cells;Clinical;Clinical Data;Clinical Trials;Cognitive;cohort;Consensus;Data;data integration;Data Set;Development;differential expression;Disease;disease heterogeneity;Disease Progression;Disproportionately impacts women;Etiology;familial Alzheimer disease;Female;Gene Expression;Genes;Genetic;genetic analysis;genetic approach;genetic architecture;Genetic Markers;genetic resource;Genetic Variation;genome resource;genomic data;Genomic Segment;genomic tools;Genomics;Genotype;Grain;Heritability;Heterogeneity;high risk;Human;human data;Human Genetics;human model;human tissue;humanized mouse;Impaired cognition;improved;in vivo;Individual;Inherited;insight;Institution;interdisciplinary collaboration;Intervention;male;Mediating;metabolic phenotype;Methodology;Modeling;Molecular;mouse genetics;mouse model;multidisciplinary;Mus;Mutation;Neurobehavioral Manifestations;Neurobiology;neuropathology;novel;Nuclear RNA;Outcome;Pathogenesis;Pathway interactions;personalized approach;personalized intervention;personalized therapeutic;Population;Precision therapeutics;presenilin-1;presenilin-2;Quantitative Trait Loci;Research;resilience;Resolution;response;Risk;Role;segregation;Severities;sex;Sex Differences;Specificity;Symptoms;System;Systems Biology;Technology;The Jackson Laboratory;Therapeutic;transcriptome sequencing;treatment response;Validation;Variant;Work

PROJECT_TITLE: Systems Genetics Analysis of Sex Differences in Alzheimer's Disease


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative Brain disorders are responsible for significant pain, suffering and economic cost. To facilitate the understanding of brain function and the development of new therapies for brain disorders, this program will produce a generation of quantitatively strong and diverse brain scientists.

PI_NAMEs: TURRIGIANO, GINA G (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurosciences;tool

PROJECT_TITLE: Quantitative Neuroscience: Tools for Bridging Levels of Analysis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: PROACTIVE MEMORY SERVICES, INC.

ORG_STATE: UT

PHR: CUSTOMIZABLE TRAINING SOFTWARE FOR PROFESSIONAL ALZHEIMER DIRECT CARE PROVIDERS  Project Narrative - ProActive Memory Services, Inc. New strategies for Alzheimer’s disease and related dementias (AD/RD) training are urgently needed for 4.6 million professional direct care providers that assist 8.3 million older adults in the US. ProActive Memory Services, Inc. will develop and test a revolutionary new strategy in assisted living facilities and personal care agencies that transforms occasional, episodic AD/RD training to continuously accessible training using mobile software. We will evaluate educational outcomes and sustained engagement and optimize our software to enhance adoption and commercialization with the ultimate goal of improving the quality of care for the growing number of Americans facing AD/RD.

PI_NAMEs: FOSTER, NORMAN LOUIS (contact)

PROJECT_TERMS: Achievement;Address;Administrator;Adoption;Alzheimer's Disease;Alzheimer's disease related dementia;American;Assisted Living Facilities;Businesses;care providers;caregiver education;Caregivers;caregiving;Caring;Characteristics;Code;Collaborations;collaborative care;commercialization;Competence;Computer software;cost;Data;Dementia;Dementia caregivers;dementia caregiving;Development;Documentation;Education;Educational Status;Empathy;evidence base;experience;falls;Family Caregiver;Feedback;flexibility;Focus Groups;Fostering;Goals;Guidelines;Home Care Services;Impaired cognition;improved;Individual;Industry;interest;Interview;Knowledge;Learning;lectures;Letters;Libraries;Long-Term Care;Marketing;Memory;Modification;novel strategies;Occupations;older adult;Outcome;Pathway interactions;person centered;Phase;preference;present value;prototype;Provider;Qualitative Research;Quality of Care;Quality of life;Research;Research Personnel;Role;Schedule;Self Care;Services;Stress;Structure;Supervision;Surveys;symposium;Technology;Testing;Text;Time;tool;Training;Work


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE This proposal will characterize novel host molecular machineries and subcellular structures that major oral opportunistic pathogen, P. gingivalis uses in order to establish a replicative niche for growth and to evade host defenses inside the human gum cells. These unknown mechanisms are critical for P. gingivalis’ successful foot-hold in the oral mucosa. Thus, the gained knowledge could ultimately help to develop molecular intervention strategies aimed at controlling P. gingivalis’ colonization and persistence inside the gum cells.

PI_NAMEs: YILMAZ, OZLEM  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Anti-Bacterial Agents;antimicrobial;Antioxidants;Apoptosis;arm;Autophagocytosis;Autophagosome;bactericide;Buthionine Sulfoximine;Cell Communication;Cell Culture System;Cell Death;cell type;Cells;Cellular biology;Chronic;Complex;Degradation Pathway;Endoplasmic Reticulum;Environment;Enzymes;Epithelial Cells;Epithelium;Equilibrium;Event;Foundations;Gingiva;Glutathione;glutathione peroxidase;Goals;Growth;Homeostasis;Host Defense;HSPB1 gene;Human;immunoregulation;Impairment;Infection;Intervention;Invaded;Joints;Knockout Mice;Knowledge;Life;Mediating;Membrane;Methods;microorganism;Microscopy;Modeling;Molecular;mouse model;Mucous Membrane;multidisciplinary;NADPH Oxidase;novel;novel strategies;Nucleoside-Diphosphate Kinase;Nutritional;opportunistic pathogen;Oral;Oral cavity;oral cavity epithelium;oral microbial community;Oral mucous membrane structure;Organism;Oxidation-Reduction;Oxidative Stress Induction;pathobiont;pathogen;Pathway interactions;Peroxidases;Phenotype;Phosphorylation;Play;Porphyromonas gingivalis;programs;Proliferating;Resolution;Role;Secure;Signal Transduction;Solid;Stress;Structure;Subcellular structure;System;Testing;Tissues;trafficking;trait;Translating;Ubiquitin;Vacuole;Variant;Virulence

PROJECT_TITLE: Turning on Persistence: Novel Molecular Determinants that Underpin P. gingivalis Intracellular Survival In Epithelial Cells


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Los Angeles

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narra+ve Alzheimer’s disease (AD) is a large and growing problem aﬀec9ng socie9es in both high- and low-income countries. Alzheimer’s disease and other forms of demen9a are debilita9ng to the pa9ents aﬀected but can also have a devasta9ng eﬀect on their families and friends.

PI_NAMEs: STRAUSS, JOHN A (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Adult;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Birth;Childhood;China;Chinese;Chinese population;Cognition;Cognitive;cognitive ability;cohort;Communities;cost of dementia;Country;Data;Dementia;dementia risk;design;Diabetes Mellitus;drinking;Earthquakes;Economics;Education;Employee;Environmental Risk Factor;Event;Extended Family;Family;Famines;farmer;Financial cost;follow-up;Friends;Funding;gender difference;Geography;Goals;Government Officials;Growth;Health;Health and Retirement Study;Health Status;hearing impairment;Household;human old age (65+);Impaired cognition;improved;Incidence;Income;India;Individual;Institution;Interview;late life;Life;Life Cycle Stages;Life Expectancy;life history;lifestyle factors;Link;Literature;Longitudinal Studies;low income country;Measures;men;Mental Depression;middle age;Modeling;Natural Disasters;novel;Obesity;Older Population;Outcome;Paper;Persons;Physical environment;physical inactivity;Politics;Population;Population Study;preference;Prevalence;protective factors;Publishing;Recording of previous events;Research;Resources;Respondent;Retirement;Risk;Risk Factors;Sampling;Smoking;Social isolation;Socioeconomic Status;Son;Stressful Event;Surveys;trend;Visual impairment;Woman;Women Status

PROJECT_TITLE: Influences of Early and Later Life Events on Cognition and All-Cause Dementia in China


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Although pediatric professional guidelines recommend screening for social determinants of health (SDOH) as a central way to promote patient and population health, to date most screening and referral efforts have occurred in the outpatient clinical setting. We propose a hybrid effectiveness-implementation cluster RCT to implement the established SDOH screening and referral intervention “WE CARE” into U.S. safety-net neonatal intensive care units to: (1) examine implementation feasibility; (2) assess its impact on receipt of community resources among low-income families; and (3) explore its effect on maternal and child health outcomes. The proposal is aligned with the National Academy of Medicine’s recent recommendations, NICHD’s mission, and Healthy People 2030’s overarching goal to “achieve health equity, eliminate disparities, and improve the health of all groups.”

PI_NAMEs: DRAINONI, MARI-LYNN ;GARG, ARVIN ;PARKER, MARGARET GRAHAM KEMPER (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Academy;Address;Affect;Age;American;arm;Attention;Birth;Body System;Caring;Child;Child Care;Child Health;Childhood;Chronic;Clinical;clinical care;clinical infrastructure;cohort;Communities;Development;Developmental Disabilities;disparity elimination;Education;effective intervention;Effectiveness;effectiveness evaluation;effectiveness/implementation hybrid;effectiveness/implementation study;Employment;Environment;Equity;ethnic health disparity;evidence base;Evidence based intervention;Family;food security;Future;Geographic Locations;Goals;Growth;Guidelines;Health;health care delivery;health disparity;health equity;High Prevalence;high risk population;Hospitalization;Hospitals;Household;Housing;Impairment;implementation research;improved;Infant;Infant Development;Infant Health;infant outcome;Inpatients;insight;Intervention;Knowledge;Life;Life Cycle Stages;Low income;lower income families;Maternal and Child Health;maternal outcome;Medical;Medicine;Mental Depression;Mental Health;Minority;Mission;Modeling;Mothers;National Institute of Child Health and Human Development;Neonatal Intensive Care;Neonatal Intensive Care Units;novel;Occupations;Outcome;Outpatients;Parents;Patients;Pediatrics;Penetration;Personal Satisfaction;Persons;Population;population health;Premature Birth;Premature Infant;Process;Proctor framework;Quality of life;racial health disparity;Recommendation;Research;Resources;Respiratory Disease;Risk;safety net;screening;screening guidelines;social;Social Conditions;social health determinants;social influence;social interventions;Social Work;socioeconomics;Standardization;Stress;System;Technology;Testing;Touch sensation;Translating;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: Implementing a Social Determinants of Health Screening and Referral Care Model in the Neonatal Intensive Care Unit

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Patient Safety;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative (2-3 sentences) A recent FDA Drug Safety Communication requires that transmucosal buprenorphine products warn patients and prescribers about a potential association between buprenorphine and poor dental outcomes. This warning is based on case reports and adverse event reporting data; no high-quality data exist to support a correlation. We propose a retrospective cohort study among a VA cohort to rigorously evaluate the association between transmucosal buprenorphine and dental outcomes.

PI_NAMEs: DURKIN, MICHAEL JOSEPH (contact);ROY, PAYEL JHOOM

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Accounting;Acute;addiction;administrative database;Adoption;Adverse event;Age;Buprenorphine;care systems;Caring;Case Study;Characteristics;Clinical;cohort;Communication;comorbidity;comparative;comparative effectiveness study;comparative safety;Control Groups;Counseling;Data;Data Reporting;Data Set;data warehouse;Dental;Dental Care;Dental caries;Diagnosis;Dose;electronic health data;Electronic Health Record;Epidemic;Etiology;Evaluation;evidence base;experience;Formulation;health care service utilization;Health Personnel;Health Services Research;Healthcare;Implant;improved;Individual;Injectable;innovation;large datasets;Light;Medical;medication for opioid use disorder;medication safety;Methadone;methamphetamine use;Methodology;Methods;mortality;Mucous Membrane;Naltrexone;National Institute of Drug Abuse;Observational Study;Opioid;opioid overdose;opioid use;opioid use disorder;Oral health;oral infection;Outcome;Patients;Pattern;Persons;Pharmaceutical Preparations;Preventive;Preventive service;Professional Organizations;Race;Recommendation;Reporting;Research Personnel;response;Retrospective cohort study;Retrospective Studies;Risk;Risk Estimate;Risk Reduction;rurality;safe patient;Safety;safety study;skills;Smoking Status;social health determinants;social stigma;Socioeconomic Status;Stigmatization;Strategic Planning;Subgroup;substance use;Time;Tooth Diseases;Tooth Loss;treatment group;trend;United States Substance Abuse and Mental Health Services Administration

PROJECT_TITLE: Oral Health Utilization and Outcomes Among Patients on Medications for Opioid Use Disorder

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative The giant elastic protein titin is crucial for the proper function of muscle, and when titin is mutated, muscle diseases occur. This proposal focuses on poorly understood functions of titin in muscle, including how titin contributes to muscle contraction. The anticipated findings likely will contribute to our understanding of the mechanistic basis of muscle diseases, and they might ultimately contribute to the development of therapies in patients with titin-based muscle diseases.

PI_NAMEs: GRANZIER, HENK L. (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Actins;Address;Affect;Ankyrin Repeat;Binding;Binding Sites;biological adaptation to stress;Biological Assay;Calcium;clinically relevant;connectin;Contracts;Data;Disease;Elasticity;Elements;energy efficiency;experience;experimental study;Family;Fiber;Generations;Glutamates;Goals;Health;In Vitro;Knockout Mice;Measures;Mechanical Stress;Mechanics;mechanotransduction;Microfilaments;Modeling;Motility;mouse model;Mus;Muscle;Muscle Contraction;Muscle function;Muscle relaxation phase;muscle stiffness;muscle stress;Mutate;Mutation;Myopathy;Myosin ATPase;myosin-binding protein C;N-terminal;novel;Patients;Pilot Projects;Property;Protein C Deficiency;Proteins;Regulation;Relaxation;Research;Resolution;response;Roentgen Rays;Role;Sarcomeres;single molecule;Site;Skeletal Muscle;Stress;Striated Muscles;Testing;therapy development;Thick Filament;Thin Filament;tool;viscoelasticity;Viscosity;Work

PROJECT_TITLE: Titin-based stiffness regulation and mechanosensing in activated skeletal muscle.


ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative The development of a pharmaceutical drug takes ~12 years on average with organic synthesis as one of the key drivers, but often the rate-limiting step. Our overall goal is to merge and integrate the unique advantages of electrochemistry and transition-metal catalysis to drive the development and discovery of organic reactions relevant to drug discovery. Specifically, we will utilize an electrocatalytic approach to improve the synthesis of two general classes of highly-sought pharmaceuticals, chiral molecules and PET imaging radiopharmaceuticals.

PI_NAMEs: MALAPIT, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Alkenes;Amides;Amines;Amino Acids;bioimaging;Carbon Dioxide;carboxylation;Carboxylic Acids;Catalysis;catalyst;Cell Nucleus;chemical reaction;Chemicals;chiral molecule;Cobalt;Collaborations;Complex;Coupling;Data Science;design;Detection;Development;disorder prevention;drug discovery;Electricity;Electrochemistry;Electrodes;Electrolyses;Electrolytes;Electrons;Excision;functional group;Goals;Grant;imaging agent;improved;interdisciplinary approach;Label;Ligands;marine;Medical;Mentors;Methods;Modification;molecular imaging;Nitriles;novel;novel strategies;Optics;Organic Chemistry;Organic Synthesis;Organometallic Chemistry;Oxidants;Pathway interactions;Patients;peptide synthase;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Physiologic pulse;polypeptide;Positron-Emission Tomography;Preparation;prevent;Process;programs;Proline;Radioactive;Radioactive Elements;Radioactivity;Radioisotopes;Radiolabeled;Radiopharmaceuticals;Reaction;Reaction Time;Reagent;Reducing Agents;Research;Series;Solid;System;Techniques;Temperature;Time;toxic metal;Tracer;Transition Elements;Work

PROJECT_TITLE: Electrocatalysis for the synthesis of chiral and PET imaging pharmaceuticals


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative  Triple negative breast cancer is the most aggressive subtype of breast cancer. The goal of this study is to generate novel therapeutic candidates with excellent potency and safety profiles for triple negative breast cancer. Successful completion of this project will lead to the development of a new class of immunotherapeutics for more effective treatment of triple negative breast cancer.

PI_NAMEs: ZHANG, YONG  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Address;Affinity;anti-cancer;Antibodies;antibody immunotherapy;Binding;Biological;Biology;Blood specimen;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Breast Cancer therapy;cancer immunotherapy;CD3 Antigens;Cell Line;cell type;Cellular Immunity;chemotherapy;clinical application;cytotoxic;Cytotoxic T-Lymphocytes;cytotoxicity;design;Development;Dioxygenases;drug development;effective therapy;Effector Cell;Encapsulated;engineered exosomes;Epidermal Growth Factor Receptor;ErbB Receptor Family Protein;Evaluation;exosome;Extracellular Domain;Fostering;Generations;Goals;Human;humanized mouse;Immune;immune checkpoint;Immune response;immunological synapse formation;immunoreactivity;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Implant;improved;In Vitro;in vivo;indoleamine;inhibitor;innovation;insight;Lead;Ligands;Link;Malignant Breast Neoplasm;Mediating;Medical;Membrane Proteins;Monoclonal Antibodies;Mus;Nanotechnology;novel;novel therapeutics;Organ;overexpression;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;pharmacologic;polypeptide;programmed cell death ligand 1;programmed cell death protein 1;Property;Protein Engineering;Pyrroles;receptor;Receptor Protein-Tyrosine Kinases;Regimen;Resistance development;Safety;Sampling;Specificity;Surface;T-Lymphocyte;targeted delivery;Therapeutic;therapeutic candidate;Toxic effect;Translations;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor necrosis factor ligand superfamily member 4;Tumor-Derived;Vesicle

PROJECT_TITLE: Reprogramming Exosomes for Novel Immunotherapy of Triple Negative Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The work proposed will lead to scientific understanding of sensory and motor functions in the human nervous system. The results will have direct relevance to the development of neuroprosthetic medical devices. Such devices can help people with severe paralysis from spinal cord lesion and other traumatic accidents, peripheral neuropathies, amyotrophic lateral sclerosis, multiple sclerosis, and stroke.

PI_NAMEs: ANDERSEN, RICHARD A (contact)

PROGRAM_OFFICER_NAME: GEBREHIWET, HERMON RUSSOM

PROJECT_TERMS: Accidents;Accounting;Address;Affect;Amyotrophic Lateral Sclerosis;Anterior;Area;arm;association cortex;Behavior Control;Body part;body position;brain control;Calibration;Cerebral cortex;Clinical;Clinical Research;clinically relevant;Code;Conflict (Psychology);Cutaneous;Data;Dependence;design;Development;Devices;Dorsal;Environment;Esthesia;experience;Eye;Feedback;flexibility;Future;Goals;grasp;Hand;Head Movements;Human;Imagery;Implant;improved;Knowledge;Learning;Lesion;limb movement;Limb Prosthesis;Limb structure;Location;Medical Device;Microelectrodes;microstimulation;Modeling;Motor;motor control;Motor Cortex;Motor Pathways;Movement;Multiple Sclerosis;multisensory;Nervous System;neural;neural prosthesis;Neurons;neurophysiology;neuroprosthesis;Output;Paralysed;Parietal Lobe;Participant;Pathway interactions;Patients;Performance;Peripheral Nervous System Diseases;Persons;Population;Positioning Attribute;Property;Proprioception;Quadriplegia;recruit;Research Design;response;Retina;Role;sensorimotor system;Sensory;sensory cortex;sensory feedback;sensory input;sensory integration;Signal Transduction;somatosensory;Somatosensory Cortex;Spinal cord injury;Spinal Cord Lesions;Stroke;Structure;System;Testing;Visual;visual feedback;visual information;Work

PROJECT_TITLE: Sensory motor transformations in human cortex


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Congenital Heart Disease;Genetic Testing;Genetics;Heart Disease;Human Genome;Pediatric;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Atrial fibrillation (AF) is a cardiac arrhythmia that affects more than 1 out of 3 adults and is caused by a wide variety of clinical and genetic risk factors. Genetic subtypes of AF may identify patients at higher risk for developing heart failure and life-threatening arrhythmias or predict response to specific AF therapies. We seek to define the cardiac phenotype and clinical outcomes of patients with AF who carry a rare variant associated with an inherited arrhythmia or cardiomyopathy syndrome and develop a prediction tool to identify patients with AF who should undergo genetic testing.

PI_NAMEs: SHOEMAKER, MOORE BENJAMIN (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Address;adjudication;Adult;Affect;African American;African American population;Age;Arrhythmia;arrhythmogenic cardiomyopathy;Atrial Fibrillation;Back;Brugada syndrome;Cardiac;cardiac magnetic resonance imaging;Cardiomyopathies;Cardiovascular Diseases;Caring;cascade genetic testing;Catecholaminergic Polymorphic Ventricular Tachycardia;Clinical;clinical care;clinical risk;clinically significant;cohort;comparison control;Consent;Data Set;demographics;Diagnosis;diagnostic criteria;diagnostic value;Dilated Cardiomyopathy;Disease;disease phenotype;disease-causing mutation;Early Diagnosis;Early identification;Early Intervention;early onset;Elasticity;Electronic Health Record;Electronic Medical Records and Genomics Network;Enrollment;Ethnic Origin;exome sequencing;Family;Fibrosis;Genes;Genetic;Genetic Diseases;Genetic Predisposition to Disease;genetic risk factor;Genetic Screening;genetic testing;genetic variant;Genetic Variation;genome resource;genome sequencing;genome-wide;Genomics;Genotype;Goals;Guidelines;Heart failure;high risk;Hypertrophic Cardiomyopathy;Image;improved;Individual;individualized medicine;individualized prevention;Inherited;inherited cardiomyopathy;Knowledge;Left;Life;Link;Logistic Regressions;Long QT Syndrome;Medical;medical schools;Monitor;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;Outpatients;Participant;Pathogenicity;Patient-Focused Outcomes;Patients;Performance;Phenotype;Play;polygenic risk score;Population;Positioning Attribute;Precision Medicine Initiative;predicting response;predictive tools;Predisposition;Probability;programs;prospective;Publishing;Race;rare variant;Recommendation;Recontacts;recruit;Registries;Reporting;Research;Resources;Rest;Risk Factors;Risk Reduction;Role;Sample Size;sex;Short QT syndrome;Signal Transduction;Stress;Subgroup;sudden cardiac death;Syndrome;Technology;Testing;Therapeutic;tool;Training;Trans-Omics for Precision Medicine;United States National Institutes of Health;Validation;Variant;Ventricular;Ventricular Arrhythmia;Visit;whole genome;Work

PROJECT_TITLE: Probing Phenotype-Genotype Relations After Whole Genome Sequencing in Patients with Atrial Fibrillation

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: D NARRATIVE An example of a somatic mutation driving dysregulation of Liquid-Liquid Phase Separation (LLPS) leading to cancer (SPOP (speckle-type POZ protein)) demonstrates the requirement of considering multiple scales in intrin- sically disordered protein (IDP) cancer biology. While not often somatically mutated, Myc is very often upregu- lated, which is an alternative means for inducing LLPS. This project is designed to assess the role of LLPS in Myc function, develop inhibitors using the ligand-cloud around a protein-cloud model, and harness the power of generative deep learning to develop IDP small molecule inhibitors functioning at both the meso-scale and atomic scale.

PI_NAMEs: SCHWING, GREGORY JOHN (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Affinity;Automobile Driving;Behavior;Binding;Binding Sites;Biological;Biological Assay;Cancer Biology;Cell Proliferation;Chemicals;Complex;Data;data integration;data mining;Databases;deep learning;deep learning model;design;Disease;DNA;Docking;drug discovery;drug efficacy;effectiveness testing;Excision;falls;Free Energy;generative models;Glioma;Goals;Grain;high throughput screening;Human;Hydrophobicity;improved;In Vitro;in vivo;inhibitor;interest;Lead;lead optimization;Learning;Libraries;Ligand Binding;Ligands;Liquid substance;machine learning method;Malignant Neoplasms;Maps;Methods;Modeling;Molecular Conformation;molecular dynamics;Molecular Weight;Mutate;MYC Family Protein;nanomolar;Oncogenic;Pancreatic Adenocarcinoma;Pathologic;Pathway interactions;peptidomimetics;Performance;Pharmaceutical Preparations;Phase;phase change;Population;Process;Property;protein protein interaction;Proteins;Proto-Oncogene Proteins c-myc;Protocols documentation;Psychological reinforcement;public database;Reaction;Reporting;Resolution;response;Role;Signal Transduction;simulation;Site;small molecule;small molecule inhibitor;small molecule libraries;Solvents;Somatic Mutation;statistics;Structure;success;Techniques;Testing;Time;Training;Transactivation;transcription factor;Transducers;Trees;triple-negative invasive breast carcinoma;virtual screening

PROJECT_TITLE: Myc Transcription Factor Inhibitor Design: Integrating Atomic and Mesoscale with Semi-Supervised Generative Deep Learning Models


NIH_SPENDING_CATS: Aging

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: PROJECT NARRATIVE Aging is the greatest risk factor for most chronic illnesses. The field of geroscience seeks to counteract the development of such diseases by understanding and manipulating the basic biological mechanisms that impact the aging process. To address the growing need for a geroscience workforce, the goal of this research education project is to increase the quality and quantity of new geroscientists entering the field by creating an Education in Aging and Geroscience Research (EAGR) program for Undergraduate students.

PI_NAMEs: CAMPELLONE, KENNETH G (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Address;Admission activity;age-related disease;Aging;aging process;base;Behavioral;Biological;Biological Aging;Biological Sciences;Biology of Aging;career development;Cellular biology;Chronic Disease;cohort;Communication;Communities;Course Content;curriculum development;design;Development;disability;disadvantaged background;Disease;Doctor of Philosophy;Education;Education Projects;education research;Educational Activities;Educational Curriculum;Educational process of instructing;Engineering;Enrollment;Event;experience;Exposure to;faculty mentor;Foundations;Generations;Genetic;Genome;Genomics;Gerontology;Geroscience;Geroscientist;gerotherapeutic;Goals;hallmarks of aging;Health;healthy aging;improved;Institution;Interdisciplinary Study;Journals;Laboratory Study;learning materials;Lesbian Gay Bisexual Transgender Queer;Literature;mathematical sciences;medical schools;meetings;member;Mentors;Minority Groups;Minority Participation;Modeling;Modernization;Nutritional;Outcome;outreach;outreach program;Paper;peer coaching;pharmacologic;Population;posters;Program Description;programs;Publishing;Reading;Research;Research Activity;Research Personnel;Research Training;Risk Factors;science education;Scientist;skill acquisition;skills;Societies;Student recruitment;student training;Students;summer research;symposium;System;Techniques;Traction;Training;undergraduate education;undergraduate research experience;undergraduate student;underrepresented minority student;Universities;Woman;Writing

PROJECT_TITLE: Undergraduate Fundamentals in Aging Research


NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Human Fetal Tissue;Mental Health;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Human fetal tissues that would otherwise be discarded are donated to this program for scientific research purposes, in full compliance with research and regulatory guidelines. The laboratory operates as a resource repository for research by systematically collecting, processing, and distributing these tissues and their derivatives to recipient biomedical scientists located at universities and non-profit institutions, nationwide. This resource is both essential and irreplaceable for facilitating research progress in a whole host of research efforts including genetics, the human variome and epigenetics, birth defects and genetic disease (both common and rare), cancer biology, developmental biology, infective disease, inflammatory and immunological disease, regenerative medicine, and the developmental origins of adult disease.

PI_NAMEs: GLASS, IAN AMOS (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Adult;adult stem cell;Animal Model;Area;Atlases;Awareness;Barker Hypothesis;base;Biological Models;Biological Products;Biology;Biomedical Research;biomedical resource;biomedical scientist;Brain;Cancer Biology;Cell model;Cell Nucleus;cell preparation;Cell Survival;cell type;Cells;Cellular Assay;Chronic;Clinic;Clinical;Collaborations;Collection;Communicable Diseases;Congenital Abnormality;Creativeness;Cultured Cells;design;Development;Developmental Biology;Developmental Gene;Diabetes Mellitus;Disease;Embryo;Engineering;Enrollment;Ensure;Epigenetic Process;epigenomics;Equity;Ethics;Experimental Designs;experimental study;Feedback;fetal;Fetal Tissue Research;Fetal Tissues;Fostering;Funding;Genes;Genetic;Genetic Diseases;Goals;Guidelines;Health;Healthcare;Human;Human Biology;Human BioMolecular Atlas Program;Human Development;human disease;human fetus tissue;human model;human tissue;humanized mouse;Immune System Diseases;Immunologics;Immunology;improved;In Situ;Inflammatory;innovation;insight;Institution;Laboratories;Laboratory Research;Logistics;Medicine;Methods;model organism;Musculoskeletal Development;Mutation;Neoplasms;neoplastic;novel;Nucleic Acids;Organ;prenatal;Preparation;preservation;pressure;Process;process improvement;programs;Protocols documentation;Provider;recruit;Regenerative Medicine;repository;Reproductive Health;Research;Research Personnel;Resources;Sampling;Services;Shipping;single cell genomics;Specimen;stem cell biology;Structure;success;Techniques;Technology;Termination of pregnancy;Time;Tissue Banks;tissue processing;Tissues;Underrepresented Populations;United States National Institutes of Health;Universities;Woman;Xenograft procedure

PROJECT_TITLE: Laboratory of Developmental Biology

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Data Science;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative It is estimated that more than 16 million people with AD live in the United States by 2050 and the predisposition to AD involves a complex, polygenic, and pleiotropic genetic architecture. This proposal will develop intelligent computer-based network medicine and systems biology tools, capable of identifying and validating human genome sequencing findings for novel risk gene discoveries and targeted therapeutic development in AD. The innovative network-based, artificial intelligence toolboxes and novel risk genes and biologically relevant targeted therapeutic approaches developed in this proposal will prove to be novel and effective ways to improve outcomes in long-term brain care for the rapidly growing AD population, an essential goal of AD precision medicine.

PI_NAMEs: BEKRIS, LYNN ;CHENG, FEIXIONG  (contact);LEVERENZ, JAMES BRUCE

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Adverse effects;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Artificial Intelligence;Bayesian Modeling;Binding;Binding Proteins;biobank;biomarker panel;Brain;brain health;candidate identification;Caring;causal variant;Cell Nucleus;cell type;Cells;Cerebrospinal Fluid;Chromatin;Clinic;Clinical;Clinical Data;Code;cohort;Complex;Computers;Data;data resource;Databases;deep learning model;Dementia;Development;Disease;Disease Outcome;drug candidate;Drug Combinations;drug discovery;drug repurposing;Drug Targeting;Electronic Health Record;endophenotype;ethnic diversity;exome sequencing;Foundations;gene discovery;Gene Expression Regulation;gene network;gene regulatory network;Gene Targeting;Genes;Genetic;genetic architecture;Genome;genome wide association study;genome-wide;genomic data;Genomics;Genotype-Tissue Expression Project;Germ-Line Mutation;Goals;Hi-C;Histones;Human;Human Genome;human genome sequencing;improved outcome;in silico;innovation;Investments;kernel methods;Link;Medicine;Methodology;Molecular;mouse model;multimodality;Multiomic Data;multiple omics;neglect;Nerve Degeneration;Network-based;Neurodegenerative Disorders;neuroimaging;new therapeutic target;novel;Nucleic Acid Regulatory Sequences;Pathogenesis;Patients;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacologic Substance;Plasma;Population;population based;Post-Translational Modification Site;precision medicine;Predisposition;Process;Protein Conformation;protein expression;protein protein interaction;protein structure;Proteins;Publications;Quantitative Trait Loci;rare variant;Research;research and development;risk variant;Sample Size;single cell analysis;statistics;Structure;success;Susceptibility Gene;System;Systems Biology;targeted treatment;Technology;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;tool;transcription factor;transcriptomics;Transgenic Mice;United States;United States National Institutes of Health;Untranslated RNA;Validation;Variant;Visualization;whole genome

PROJECT_TITLE: Alzheimer's MultiOme Data Repurposing: Artificial Intelligence, Network Medicine, and Therapeutics Discovery


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Oral anticancer (OAC) agents have revolutionized treatment of once-fatal malignancies by extending survival and delaying progression; however, OAC adherence is suboptimal in clinical practice. The proposed research project integrates health behavior and implementation science theories, models, and frameworks to translate observations from key stakeholders into an adherence coaching intervention that improves medication adherence. Due to the proposed methods, the final adherence intervention has a high potential of translation by benefiting cancer patients on OAC agents in both academic/urban and rural settings.

PI_NAMEs: MULUNEH, BENYAM  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Academic Medical Centers;acceptability and feasibility;Address;Adherence;adherence rate;Administrator;Adverse effects;Agreement;anti-cancer;Antineoplastic Agents;Attitude;Award;Behavior;behavior influence;Behavioral;cancer care;Cancer Center;Cancer Patient;cancer therapy;Cardiology;career;Caring;Charge;Chronic Leukemia;Clinic;Clinical;Clinical Oncology;Clinical Pharmacists;clinical practice;Clinical Trials;Cognition;Cognitive;Communicable Diseases;community center;Complex;cost;Data;design;Drops;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;effectiveness/implementation design;effectiveness/implementation study;Environment;Equity;Evaluation;expectation;experience;Face;Faculty;Focus Groups;Funding;Future;Goals;Grant;Health behavior;health care service utilization;Health Promotion;Healthcare;Home;Hospital Administrators;Hybrids;implementation evaluation;implementation outcomes;implementation science;improved;Institution;interest;Intervention;intervention mapping;intervention refinement;Interview;K-Series Research Career Programs;Knowledge;Malignant Neoplasms;medication compliance;Mentors;Mentorship;Methods;Modeling;National Cancer Institute;Needs Assessment;Nurses;Oncologist;Oncology;Oncolytic;Oral;Outcome;Patient Education;patient oriented;Patients;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Phase;post implementation;Primary Care;programs;Publishing;Randomized;Recommendation;Research;Research Personnel;Research Project Grants;Resources;Rural;rural setting;satisfaction;Self Efficacy;side effect;skill acquisition;skills;social cognitive theory;Social support;socioeconomics;Structure;success;Surveys;symptom management;Testing;theories;therapy design;Training;Translating;translational potential;Uninsured Medical Expense;United States National Institutes of Health;Urban Community;urban setting

PROJECT_TITLE: Design and implementation of a social cognitive theory-based medication adherence coaching intervention

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative To optimize cervical cancer (CXCA) screening and the pre-cancer treatment cascade for women living with HIV (WLWH) in Zimbabwe and in other lower middle income countries (LMIC), the University of California, San Francisco and University of Zimbabwe–Clinical Trials Research Centre (UZ-CTRC), in collaboration with local PEPFAR-funded implementation partners Organization for Public Health Interventions and Development (OPHID) and the Zimbabwe Technical Assistance, Training and Education Center for Health (Zim-TTECH) (collectively, ZIM-CASCADE) propose to serve as a LMIC CASCADE UG1 Clinical Site. ZIM-CASCADE will contribute critical evidence to inform optimization, implementation, and scale-up of effective CXCA prevention interventions for WLWH in resource-limited settings, and the multi-modal CASCADE data will inform public health policy in Zimbabwe and globally.

PI_NAMEs: CHIRENJE, ZVAVAHERA MIKE (contact);GUZHA, BOTHWELL

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Acetic Acids;advanced disease;Advocacy;aged;Algorithms;antiretroviral therapy;Area;base;California;cancer epidemiology;cancer prevention;Cancer Prevention Intervention;Cancer Prevention Trial;cancer therapy;Caring;Cervical;cervical cancer prevention;Cervical Cancer Screening;Clinical;clinical infrastructure;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;clinically significant;Cold Therapy;Collaborations;Communities;community engagement;community partners;Country;Cytology;Data;Dedications;Development;Diagnosis;DNA;Eligibility Determination;eligible participant;Enrollment;Ensure;Equity;experience;Funding;Genotype;Guidelines;Gynecologic Oncologist;Health;Health Policy;High Prevalence;HIV;HIV/AIDS;HPV-High Risk;Human papilloma virus infection;Human Papillomavirus;Incidence;Infrastructure;innovation;insight;Intervention;investigator training;Laboratories;Leadership;Lesion;Life Cycle Stages;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mentors;migration;Mission;Multi-Institutional Clinical Trial;multimodality;next generation;Outcome;Participant;Pathogenesis;Performance;Persons;Phase;point of care;Policies;Population Density;Population Heterogeneity;Pragmatic clinical trial;premalignant;Prevention;preventive intervention;primary care clinic;primary health center;Procedures;programs;Protocols documentation;Public Health;public health intervention;Publications;recruit;Regulation;Research;Research Activity;Research Infrastructure;Research Personnel;Resource-limited setting;Resources;retention rate;Risk;San Francisco;scale up;Scientist;screening;Screening for cancer;Seminal;Site;System;Testing;therapeutic HPV vaccine;Thermal Ablation Therapy;Training;Training and Education;treatment duration;Treatment Efficacy;treatment optimization;trial planning;United States National Institutes of Health;Universities;Virus Diseases;Visual;Woman;Women's prevalence;women's prevention;women's treatment;Women's trial;World Health Organization;Zimbabwe

PROJECT_TITLE: Implementing HIV/Cervical Cancer Prevention CASCADE Clinical Trials in Zimbabwe (ZIM-CASCADE)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Neuroanatomical heterogeneity in Alzheimer disease (AD) has important implications for clinical outcomes as well as patient-specific treatments, however, little is known regarding AD biomarker topographical patterns in ethno-racial groups as well as the effects of structural and social determinants of health (SSDOH) on heterogeneity. The present study utilizes the National Institute on Aging (NIA) - Alzheimer Association Research Framework and the NIA’s Health Disparities Framework to characterize heterogeneity in AT(N) imaging markers, as well as the effects of SSDOH factors on heterogeneity, in a racially and ethnically diverse population. This line of work will aid in guiding precision medicine and in recruitment efforts in clinical trials while highlighting potential ethno-racial disparities.

PI_NAMEs: MEEKER, KARIN  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Acculturation;Affect;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;apolipoprotein E-4;Area;Atrophic;Biological Markers;Black Populations;Brain imaging;Brain region;cerebral atrophy;Classification;Clinical;clinical heterogeneity;Clinical Trials;Cognitive;cohort;Communities;Community Health;Data;deprivation;design;Disease;disease heterogeneity;diverse data;Education;ethnic diversity;Ethnic Origin;ethnoracial;ethnoracial disparity;follow-up;functional outcomes;Genetic;Genotype;Goals;Health;health disparity;Heterogeneity;Hippocampus;Household;Image;imaging biomarker;Income;indexing;Individual;individualized medicine;Investigation;Lateral;Liquid substance;Literature;Machine Learning;machine learning method;Magnetic Resonance Imaging;Measures;Medial;Mediating;Mentors;Mexican Americans;multi-racial;National Institute on Aging;Nerve Degeneration;Neuroanatomy;neuroimaging;neuroimaging marker;Not Hispanic or Latino;Outcome;Parietal;Pathogenesis;Pathologic;Pattern;Phase;Population Heterogeneity;Positioning Attribute;Positron-Emission Tomography;precision medicine;racial difference;racial diversity;recruit;Regional Disease;Research;Research Personnel;Resources;Sampling;social;social health determinants;Socioeconomic Status;stem;structural determinants;tau aggregation;tau Proteins;Training;Underrepresented Minority;Work

PROJECT_TITLE: Understanding ethno-racial differences in AT(N)-defined heterogeneity profiles

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: FLAGSTAFF

ORG_NAME: NORTHERN ARIZONA UNIVERSITY

PHR: NARRATIVE Valley Fever is a fungal disease that causes mortality and morbidity across a large range of the western United States. Our work will lead to a better understanding of the fungal infective process, which will help in the development of prevention, therapeutic, and diagnostic strategies. Our ultimate goal is the development of a highly efficacious nucleic acid vaccine to provide protection against Valley Fever.

PI_NAMEs: KEIM, PAUL STEPHEN (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Animal Model;Animals;Antibodies;Antigens;Basic Science;Clinical;clinical research site;Clinical Trials;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;Communities;companion diagnostics;Complex;CRISPR/Cas technology;Data;desert fever;design;Development;Diagnostic;diagnostic development;diagnostic signature;diagnostic strategy;Diagnostic tests;diagnostic tool;Disease;disease diagnosis;DNA;DNA sequencing;DNA Vaccines;Epitopes;Gene Expression;Gene Expression Profile;gene gun;gene product;Genes;Goals;Human;human disease;Immune;Immune response;Immunization;in vivo;Infection;Infrastructure;Insecta;insight;Institution;Knock-out;knockout gene;Knowledge;Link;Lipids;Location;longitudinal analysis;Macaca nemestrina;Messenger RNA;Modality;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;nano-string;nanoGold;nanoparticle;nonhuman primate;novel;novel diagnostics;novel vaccines;Nucleic Acid Amplification Tests;Nucleic Acid Vaccines;Nucleic Acids;pathogen;Pathogenesis;Patients;Pattern;Peptides;Population;prevent;Prevention;Process;Protein Secretion;Proteins;Research;Research Personnel;Research Project Grants;respiratory;response;RNA;RNA replication;RNA vaccination;RNA vaccine;Role;screening;serological marker;Serology test;T cell response;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;Time;tool;transcriptome sequencing;Translational Research;United States;Vaccination;Vaccine Antigen;vaccine candidate;Vaccine Design;vaccine development;vaccine evaluation;Vaccines;Vertebrates;Virulence;Virulence Factors;virulence gene;Waxes;Work

PROJECT_TITLE: Early in vivo Expressed Antigens and their Role in Virulence, Immune Response, and Vaccines for Coccidioidomycosis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Valley Fever

PROJECT_TERMS: Accounting;Animal Model;Antigens;Area;Arizona;Award;Budgets;Businesses;Clinical;clinical trial readiness;Coccidioidomycosis;Collaborations;collaborative environment;Communication;Communities;Data;desert fever;Development;Diagnostic;early-career faculty;Ensure;Evaluation;experience;Faculty;Familiarity;Feedback;Fostering;Funding;Goals;Human Resources;Immune response;in vivo;Individual;innovation;Institution;Joints;Knowledge;Lead;Leadership;Length;Life;Location;Medical center;meetings;member;Mentors;Monitor;National Institute of Allergy and Infectious Disease;novel vaccines;Office of Administrative Management;outreach;Performance;Pilot Projects;Postdoctoral Fellow;Primates;Productivity;programs;Publications;Reporting;Research;research and development;Research Institute;Research Project Grants;Resources;Role;Schedule;Scheme;Series;Services;Structure;student mentoring;Students;success;synergism;Time;timeline;Training;translational genomics;Travel;United States National Institutes of Health;Universities;Vaccines;Video Recording;Videoconferencing;virtual;Virulence;Washington;Work;working group

PROJECT_TITLE: Early in vivo expressed antigens and their role in virulence, immune response, and vaccines for coccidioidomycosis


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE: The emergence of artemisinin-resistant Plasmodium falciparum parasites imperils malaria treatment and control worldwide. The proposed research will employ mass spectrometry-based techniques and targeted gene knockdown approaches to define the role of tRNA modifications as an epigenetic mechanism used by resistant parasites to create a “just-in-time” change in their parasite proteomes and survive artemisinin treatment. Understanding how resistance develops will inform new strategies to treat drug-resistant malaria.

PI_NAMEs: SMALL-SAUNDERS, JENNIFER L. (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Acetylation;Acetyltransferase;Africa;Amino Acyl Transfer RNA;Aminoacyl-tRNA hydrolase;Applied Genetics;Artemisinins;asexual;Asia;base;biological adaptation to stress;Biology;Biomedical Research;Blood;career;Cellular Stress;Codon Nucleotides;Collection;Communicable Diseases;Complex;Coupled;Data;Development;Dimethyl Sulfoxide;Doctor of Philosophy;Drug resistance;Endocytosis;Engineering;Environment;environmental enrichment for laboratory animals;Enzymes;Epigenetic Process;epigenetic regulation;Eukaryota;experimental study;Exposure to;Genes;Genetic;genetic approach;Genetic Transcription;Hemoglobin;Homologous Gene;Immunology;innovation;insight;Kinetics;knock-down;Laboratories;Lead;Liquid Chromatography;Malaria;Mass Spectrum Analysis;Mediating;Medical center;Medicine;Mentors;Metabolic;Microbiology;Modification;Molecular;multidisciplinary;multiple omics;mutant;Mutation;Nutritional;Parasite resistance;Parasites;Parasitology;Pathway interactions;Patient Care;Pharmaceutical Preparations;Physicians;Physiologic pulse;Plasmodium falciparum;Play;Positioning Attribute;posttranscriptional;pressure;Process;programs;Prokaryotic Cells;Proteins;Proteome;Proteomics;Reaction Time;Reproducibility;Research;Resistance;Resistance development;resistant Plasmodium falciparum;response;Ribosomes;RNA;Role;Sampling;Scientist;Secondary to;sensor;South America;Southeastern Asia;Stress;System;tandem mass spectrometry;Techniques;Testing;Time;tool;Training;Transcriptional Regulation;transcriptome sequencing;Transfer RNA;Translational Regulation;Translations;Universities;Up-Regulation;Variant

PROJECT_TITLE: tRNA modification reprogramming in artemisinin-resistant Plasmodium falciparum: An epigenetic driver of resistance?

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Valley Fever

PI_NAMEs: BARKER, BRIDGET MARIE (contact)

PROJECT_TERMS: Address;Animal Model;Animal Testing;Animals;Antibody titer measurement;Antigens;Arizona;Attenuated Vaccines;Basic Science;Biological Models;Biometry;Breeding;C57BL/6 Mouse;candidate identification;CD8-Positive T-Lymphocytes;chronic infection;Clinic;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;cohort;Collaborations;Communities;comparative;cost effective;CRISPR/Cas technology;Data;desert fever;Development;Diagnostic;Diagnostic tests;Disease;disease model;Disease Progression;DNA;dosage;Dose;Early identification;Epitopes;experience;experimental study;Future;Gene Deletion;Goals;Human;Immune;Immune response;Immunity;Immunization;Immunize;Immunology;improved;in vivo;Inbred BALB C Mice;Incidence;Individual;Infection;Institution;Invertebrates;Investigation;Knock-out;knowledge translation;Location;Lung;Macaca;Macaca nemestrina;Modeling;Morphology;mortality;Moths;mouse model;Mus;nonhuman primate;novel;novel therapeutics;novel vaccines;Nucleic Acid Vaccines;Nucleic Acids;Pathology;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phase;Population;Predisposition;Preventive vaccine;Primates;Productivity;programs;Proteins;Rapid screening;Research;Research Project Grants;Resources;response;risk mitigation;RNA;Role;screening;Serum;Source;Specimen;Speed;T-Cell Depletion;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;Testing;Therapeutic Agents;Tissue Sample;Tissues;tool;Translational Repression;Universities;Vaccinated;vaccine development;vaccine evaluation;vaccine trial;Vaccines;Virulence;Virulence Factors;Waxes;Work


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related;Valley Fever

PROJECT_TERMS: adaptive immune response;Adjuvant;Algorithms;Animal Model;Animals;Antibodies;Antigens;Applied Genetics;Attenuated;Bioinformatics;Biology;biomarker identification;Candidate Disease Gene;Cellular Immunity;Centers for Disease Control and Prevention (U.S.);Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;Collaborations;cost;CRISPR/Cas technology;Data;Data Analyses;desert fever;Development;Diagnostic;diagnostic development;Diagnostic tests;diagnostic tool;Disease;Disease Outcome;disorder prevention;Fungal Drug Resistance;Gene Deletion;Gene Expression Profiling;gene function;Gene Proteins;Gene Silencing;Gene Targeting;Generations;Genes;genetic analysis;genetic approach;Genetic Transcription;genome analysis;genome sequencing;genomic data;Genomics;Goals;Growth;Health;Human;Hypothetical Protein;Immune response;Immunity;Immunization;immunogenic;immunogenicity;improved;in silico;In Vitro;in vivo;Incidence;Infection;insight;Investigation;Knock-out;Knowledge;Length of Stay;Life;Lung;Marketing;Methods;Mus;Mycoses;nano-string;novel;Nucleic Acid Vaccines;Parents;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Patients;Play;Population;Production;protein complex;Protein Secretion;Proteins;Reaction;Recombinant Proteins;Recombinants;Reporting;Research;Research Project Grants;Research Proposals;response;reverse genetics;Role;Safety;Serology test;side effect;Sister;Structure;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;targeted biomarker;Testing;Therapeutic;tool;Transcript;transcriptome sequencing;treatment strategy;Vaccination;Vaccine Antigen;vaccine candidate;Vaccine Design;vaccine development;Vaccines;Virulence;Virulence Factors;whole genome