NIH_SPENDING_CATS: Biomedical Imaging;Chronic Pain;Genetics;Neurosciences;Opioids;Pain Research;Precision Medicine

PI_NAMEs: AUBE, JEFFREY  (contact)

PROJECT_TERMS: Affective;Analgesics;analog;Animals;antagonist;Antibodies;antinociception;Binding;Biological;Biological Assay;blood-brain barrier permeabilization;Brain;brain tissue;Chimeric Proteins;Confocal Microscopy;Consumption;delta opioid receptor;Development;Dimensions;Drug Kinetics;experience;experimental study;FOS gene;FOS Protein;G-Protein-Coupled Receptors;Genetic Transcription;Goals;Human;Image;Immediate-Early Genes;Immunohistochemistry;in vivo;in vivo evaluation;Individual;Isotope Labeling;Knock-in Mouse;Knockout Mice;Label;Ligands;Light;Measures;Mediating;Microscopy;Molecular;Molecular Target;Motivation;mouse genetics;mu opioid receptors;Mus;neural circuit;Neurons;Nociceptors;novel;novel marker;Opioid Receptor;Pain;pain perception;Pathway interactions;Peptides;Pharmaceutical Chemistry;pharmacodynamic biomarker;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Positron-Emission Tomography;pre-clinical;Proteins;Publishing;Radioactive;Radiolabeled;radioligand;Reagent;receptor;Receptor Activation;Reporting;Research;Resolution;Rodent;Signal Transduction;small molecule;Specificity;Stimulus;Tachykinin Receptor;TACR1 gene;targeted agent;Techniques;Testing;Therapeutic Effect;therapeutic target;Time;Tissues;Validation;Venus

PROJECT_TITLE: Discovery and/or Validation of Pharmacodynamic Markers


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Immunotherapy;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE Uncovering the immune-based mechanisms underlying brain decline during aging should give important insights into the factors that control function and regeneration in the normal aging nervous system as well as in age- related neurodegenerative diseases such as Alzheimer’s disease.

PI_NAMEs: BRUNET, ANNE  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Administrative Supplement;Affect;age related neurodegeneration;age-related disease;Aging;aging brain;aging related;Alzheimer's Disease;Anti-Inflammatory Agents;Brain;Cell Physiology;cell type;Cells;cohort;cytokine;Dissociation;Engineering;experimental study;Foundations;functional restoration;Future;Goals;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunotherapy;improved;Inflammation;Injury;insight;Intervention;Knowledge;Mus;Natural regeneration;Nervous System;Neurodegenerative Disorders;normal aging;Organ;restoration;single-cell RNA sequencing;Stimulus;T-Lymphocyte;Technology;Tissues;transcriptomics;Work

PROJECT_TITLE: T cells in the aging brain

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Children with type 1 diabetes (T1D) are at increased risk for neurocognitive complications, but the risk and protective factors are not well understood. As a Clinical Center, our multidisciplinary team will establish a diverse cohort of school-aged children with newly diagnosed T1D and a comparison group of children without diabetes. This important project has the potential to influence standards of clinical care and identify targets for future interventions to improve brain health and psychosocial function for children with T1D.

PI_NAMEs: JASER, SARAH SANDERS (contact);JORDAN, LORI CHAFFIN

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: 11 year old;Academic Medical Centers;Address;Adolescent;Adult;adverse childhood events;Affect;Anisotropy;anxiety symptoms;Area;Award;Behavioral Research;Biometry;Black race;Brain;brain health;Caregivers;Child;Child Care;Childhood;Childhood diabetes;Chronic;Clinical;clinical care;clinical center;clinical predictors;Cognitive;cognitive function;cohort;Collaborations;Collection;community engagement;comparison group;critical period;Data;Dementia;density;depressive symptoms;deprivation;design;Development;Devices;diabetes distress;diabetes management;Diabetes Mellitus;Diabetic Ketoacidosis;Diffusion Magnetic Resonance Imaging;Disparity;Distress;Endocrinologist;Enrollment;Ethnic Origin;Ethnic Population;executive function;Exhibits;Exposure to;externalizing behavior;Frequencies;Fright;Future;Glucose;glycemic control;Glycosylated hemoglobin A;Hyperglycemia;Hypoglycemia;Image;imaging science;Impaired cognition;improved;Income;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Intervention;Learning;Life;Longitudinal cohort study;lower income families;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;marginalized population;Matched Group;Measures;member;Memory;Methods;minority children;modifiable risk;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Neighborhoods;nerve injury;Neurocognitive;Neurocognitive Deficit;neurocognitive test;neuroimaging;Neurologist;Neurons;Newly Diagnosed;Not Hispanic or Latino;Outcome;Outcome Assessment;peer;Population;Population Heterogeneity;Positioning Attribute;Prevention;primary outcome;programs;prospective;Prospective Studies;protective factors;Protocols documentation;Psychologist;psychosocial;Puberty;Race;racial diversity;racial minority population;racial population;Recording of previous events;Research;Resolution;Risk;Risk Factors;Sampling;School-Age Population;Scientist;Severities;Site;skills;Sleep;sleep quality;social health determinants;Socioeconomic Status;Structure;System;Testing;Time;tool;white matter;Work

PROJECT_TITLE: Neurocognitive Complications of Pediatric Type 1 Diabetes: Identifying Modifiable Risk and Protective Factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-1 (M3)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: GLENSIDE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ARCADIA UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Short interpregnancy interval is associated with adverse maternal and infant outcomes. Little is known about the sociocultural and demographic factors associated with short interpregnancy intervals in African immigrant women living in the US. The proposed mixed methods study is designed to elucidate a community-informed understanding of social and cultural norms and demographic factors related to birth spacing and short interpregnancy intervals, which will inform the modification of existing relevant measures or the development of a new measure, if needed, and validation of a measure of underlying sociocultural constructs related to birth spacing and interpregnancy intervals in African immigrant women in the US.

PI_NAMEs: OLORUNSAIYE, COMFORT Z. (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;Address;Admission activity;adverse maternal outcomes;adverse outcome;Africa South of the Sahara;African;Age;aged;American College of Obstetricians and Gynecologists;Behavior;Belief;Birth;Birth Intervals;Black race;care seeking;career development;clinically relevant;cognitive testing;Communities;community engaged research;community organizations;congenital anomaly;Contraception Behavior;contraceptive practice;Contraceptive Usage;Country;Course Content;culturally appropriate intervention;Data Collection;Demographic Factors;design;Development;Education;Environment;experience;Factor Analysis;Family;family influence;Family Planning;Feedback;Fertility;field study;Future;Ghana;Goals;Grant;Guidelines;hands on research;health belief;health disparity populations;Healthcare;high risk;Home;Immigrant;Immigrant community;Immigration;improved;Individual;Infant Mortality;infant outcome;interest;Intervention;Interview;knowledge base;Liberia;Low Birth Weight Infant;Maternal Mortality;Measurement;Measures;men;Mentors;Methods;Modeling;Modification;Neonatal Intensive Care Units;Nigeria;novel;Outcome;Paper;Perception;Persons;Phase;Philadelphia;Population;postpartum contraception;Pregnancy;Premature Birth;programs;Property;Psychometrics;Publications;Qualitative Methods;rapid growth;Recommendation;reproductive;Reproductive Health;Research;Risk Factors;Sampling;Science;Shapes;Sierra Leone;Small for Gestational Age Infant;social;social culture;social factors;social norm;social stigma;Social support;sociocultural determinant;Structure;Students;Testing;tool;Universities;Uterine Rupture;Validation;Vulnerable Populations;White Women;Woman;women versus men;World Health Organization

PROJECT_TITLE: Developing and testing a measure of sociocultural norms related to interpregnancy intervals in African immigrants in the US.

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

ORG_STATE: MD

PHR: The majority of older Veterans do not meet the minimum healthy diet or physical activity recommendations, despite known benefits. Identifying novel ways to increase adherence to rehabilitation programs that improve dietary quality and physical activity may reduce the risk of disability in older Veterans. Peer-based interventions may be one method to facilitate lasting behavioral change since peers often share a common culture and knowledge about the problems that their community experiences. We propose to develop and evaluate a novel peer-led diet and exercise intervention that targets older Veterans with multiple chronic health conditions. Successful development and pilot of this intervention will provide the preliminary data for a larger multisite trial focused on the use of peer-led interventions to improve long-term compliance to lifestyle interventions in older Veterans.

PI_NAMEs: ADDISON, ODESSA  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;adherence rate;Adoption;Aerobic Exercise;Affect;Age;Aging;Agriculture;American;Baltimore;Behavior;Behavioral;Body Weight decreased;Boredom;cardiovascular health;Chronic;Chronic Disease;college;Communities;Consumption;cost;Data;design;Development;Diet;dietary;dietary guidelines;Dietary intake;Dietary Intervention;disability risk;effective intervention;Elderly;energy balance;Energy Intake;evidence base;Evidence based intervention;Exclusion;Exercise;exercise intervention;experience;family support;Feedback;flexibility;Focus Groups;Food Access;food security;Goals;good diet;Guidelines;Habits;Health;Health behavior;Health behavior change;Health Promotion;human old age (65+);improved;improved mobility;Individual;Intervention;intervention delivery;intervention participants;Interview;Knowledge;Language;Life Style;lifestyle intervention;Longterm Follow-up;Medical;Methods;military veteran;Mobility decline;Morbidity - disease rate;Motivation;multi-site trial;multiple chronic conditions;novel;older adult;Outcome;patient engagement;peer;peer support;Phase;Physical activity;physical inactivity;Pilot Projects;Positioning Attribute;preservation;programs;Publishing;Qualitative Methods;Questionnaires;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recreation;recruit;Rehabilitation therapy;Reporting;Research;research and development;resistance exercise;Resources;Risk Reduction;Role;satisfaction;Self Efficacy;Site;sleep pattern;social;Sports Medicine;Surveys;Telephone;theories;Training;Underrepresented Minority;Unhealthy Diet;urban area;urban dwelling;Veterans;virtual;Walking;Weight maintenance regimen

PROJECT_TITLE: The Development and Implementation of a Peer-Led Diet and Exercise Intervention in Older Urban Dwelling Veterans with Dysmobility

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE In the current proposal, we will examine the potential of PNPT1-mediated RNA decay as novel vulnerability of triple negative breast cancer (TNBC). We will assess the effect of PNPT1 perturbation on induction of dsRNA- mediated antiviral responses and on overall RNA metabolism in TNBCs, as well as evaluate the importance of PNPT1 on TNBC progression. The proposed project may provide novel insights into how RNA decay helps sustain TNBC growth and survival and serve as a foundation for the development of novel therapeutic approaches targeting PNPT1 for the potential treatment of TNBCs.

PI_NAMEs: YANG, ANDREW  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 5'-exoribonuclease;Alkylation;Anti-viral Response;Antibodies;Apoptotic;Breast Cancer Cell;Breast Cancer cell line;breast cancer progression;breast cancer survival;cancer cell;Cancer Etiology;Cell Death;Cellular Stress;chemical genetics;Cytoplasm;Databases;Defect;Dependence;Development;Disease;DNA;Double-Stranded RNA;Evaluation;Excision;Exoribonucleases;Foundations;Gene Expression;Gene Expression Regulation;Genes;Genetic Screening;Genetic Transcription;genome-wide;Growth;Human;Immune;Immunofluorescence Immunologic;Immunoprecipitation;Impairment;In Vitro;in vivo;insight;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Mediating;Metabolic;Mitochondria;Modeling;Molecular Machines;mouse model;novel;novel therapeutic intervention;Nuclear;Oncogenes;Pathway interactions;phosphoproteomics;Play;prevent;Proliferating;protein expression;Proteomics;Proto-Oncogene Proteins c-myc;Research;response;RNA;RNA chemical synthesis;RNA Decay;RNA metabolism;RNA Processing;RNA Splicing;Role;sensor;Signal Transduction;Stains;Sulfhydryl Compounds;SUM-159 Breast Cancer Cell Line;System;Testing;therapeutic target;tool;Transcript;transcriptome;transcriptome sequencing;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor progression;Viral;Women's mortality;Xenograft Model

PROJECT_TITLE: Novel Triple-Negative Breast cancer vulnerability governed by PNPT1-mediated RNA decay


FUNDING_MECHANISM: OTHERS

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Autonomic nervous system dysfunction and blood pressure (BP) fluctuations contribute to the increased cardiovascular disease risk in the spinal cord injury (SCI) population; however, treatment of BP fluctuations is not a clinical priority. This is due, in part, to the lack of safe and effective interventions, even though mounting evidence strongly supports adverse effects of BP instability on cognitive function and quality of life. Identifying individualized transcutaneous spinal cord stimulation (TSCS) parameters that safely and effectively increase and stabilize BP in Veterans with SCI will provide the foundational evidence to support eventual wide-spread clinical utility throughout the VA healthcare system. It is anticipated that these data will begin to establish a standard methodology for TSCS mapping of spinal autonomic circuits to promote restoration of orthostatic BP, improve independence and quality of life for Veterans with SCI.

PI_NAMEs: PETERS, CAITLYN G. (contact)

PROJECT_TERMS: Activities of Daily Living;Adverse effects;Aldosterone;Applications Grants;arterial stiffness;associated symptom;Autonomic Dysreflexia;Autonomic nervous system;Biological Assay;Biophysics;Blood Flow Velocity;Blood Pressure;blood pressure control;blood pressure reduction;blood treatment;Blood Vessels;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular health;Cervical spinal cord injury;Chest;Chronic;Clinical;Clinical Research;cognitive function;Compensation;Data;Decentralization;Dependence;disorder risk;effective intervention;Electrodes;Electromyography;Equipment;experience;falls;Foundations;Frequencies;Functional disorder;Future;General Population;Goals;Grant;Growth;Head;Healthcare Systems;Home;Hormones;Hyperactivity;Hypotension;Hypotensives;Impaired cognition;improved;Individual;injured;Intervention;Investigation;knowledge base;Laboratories;Lesion;Link;Literature;Maintenance;Maps;Medical center;Mentors;Mentorship;Methodology;Methods;Morbidity - disease rate;mortality;Motor;neuroregulation;Neurostimulation procedures of spinal cord tissue;Nonpharmacologic Therapy;Norepinephrine;Orthostatic Hypotension;Personal Satisfaction;Physical therapy;Physiologic pulse;Physiological;Plasma;Population;Process;Quality of life;Ramp;Rehabilitation therapy;Renin;Renin-Angiotensin-Aldosterone System;Reporting;Research;Research Personnel;response;restoration;Satellite Centers;Severities;Signal Transduction;skills training;Spinal;Spinal Cord;Spinal cord injury;spine bone structure;Standardization;statistics;Supination;Symptoms;Testing;Training;transcutaneous stimulation;Veterans;Width;Writing

PROJECT_TITLE: Targeted Transcutaneous Stimulation to Restore Autonomic Cardiovascular Health in Veterans with Spinal Cord Injury

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARATIVE Alzheimer’s Disease (AD) currently affects 6.2 million Americans over the age of 65 and this number is expected to double in the next 30 years. Recent studies have demonstrated that mitochondrial calcium transport is an effective therapeutic strategy in alleviating neurocognitive pathology in models of AD; given the repeated failure of amyloid-targeted therapeutics in clinical trials, this represents an exciting opportunity to overcome the barrier to effective AD treatments. This proposal aims to understand how MICU3, a CNS-specific regulator of mitochondrial calcium uptake that is downregulated in AD, affects development and progression of neurodegeneration in AD.

PI_NAMEs: COHEN, HENRY  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 1 year old;3xTg-AD mouse;Ablation;Address;Affect;aged;Aging;Agonist;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;American;Amyloid;Amyloid beta-Protein;Aphasia;Biological Assay;Biological Availability;Brain;brain parenchyma;Calcium;calcium uniporter;Cell Death;Cell Line;Central Nervous System;Clinical;Clinical Trials;Cognitive deficits;Conceptions;conditioned fear;constitutive expression;Coupled;Cues;Data;Deposition;Development;Disease;Enterobacteria phage P1 Cre recombinase;extracellular;Failure;follow-up;Genes;Genetic;Genetic Predisposition to Disease;Glycolysis;Hippocampus;Histopathology;Homeostasis;Human;human old age (65+);Impaired cognition;In Vitro;inducible Cre;Intervention;Knock-out;Knockout Mice;Learning;Measures;Mediating;Membrane;Membrane Potentials;Memory;Metabolic;Mitochondria;mitochondrial membrane;mitochondrial metabolism;Mitochondrial Swelling;Modeling;Molecular;Motor;Motor Activity;mouse model;Mus;mutant;Mutant Strains Mice;Nerve Degeneration;Neurocognitive;Neurocognitive Deficit;neuromuscular;neuron loss;Neuronal Dysfunction;Neurons;overexpression;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phenotype;Physiology;Probability;Production;Prosencephalon;Protein Family;ratiometric;Reactive Oxygen Species;Regulation;Reporter;Reporting;Respiration;response;Role;Rotarod Performance Test;Rupture;Sampling;Series;Stress;Superoxides;Tamoxifen;targeted treatment;tau Proteins;Testing;Therapeutic;therapeutic target;therapeutically effective;Time;uptake

PROJECT_TITLE: The Role of MICU3 in Alzheimer's Disease Pathogenesis


ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: Apathy, a profound loss of initiative and motivation, is often seen in older Veterans with memory problems. Apathy leads to serious health problems, increases dependency, and caregiver burden. If untreated, apathy hastens the progression to frank dementia. In a pilot study, we found that apathy, working memory, and function can be restored using magnetic stimulation in some but not all older Veterans. The reason for this variation is unknown. We propose a three-phase study in 125 older Veterans with mild memory problems. Their motivation, memory, and function will be measured periodically. Veterans with apathy that are eligible for treatment will receive either real or sham magnetic stimulation to the front part of their brain over 20 sessions. Genetic testing and biomarkers will be used to differentiate those who respond to magnetic stimulation from those who do not. Impact on function, quality of life, and rates of progression to dementia will also be studied.

PI_NAMEs: PADALA, PRASAD R. (contact)

PROJECT_TERMS: actigraphy;Alzheimer's Disease;Apolipoprotein E;apolipoprotein E-4;Behavioral;behavioral response;Biological Markers;Blood;Brain;Brain-Derived Neurotrophic Factor;burden of illness;Caregiver Burden;carrier status;Clinic;clinical practice;clinically relevant;Cognition;Cognitive;comorbidity;daily functioning;Data;Dementia;Dependence;design;disability;Disease Marker;Dopamine;Dopaminergic Agents;Double-Blind Method;Early Intervention;efficacy evaluation;Eligibility Determination;eligible participant;Enrollment;Equipment and supply inventories;Executive Dysfunction;executive function;follow-up;Foundations;Frequencies;frontal lobe;Functional disorder;functional improvement;functional status;Genetic Markers;genetic testing;Genotype;Goals;Health;Health Status;Impairment;improved;Individual;innovation;Intervention;intervention effect;Knowledge;Left;Letters;Longterm Follow-up;Magnetism;Measurement;Measures;Medical center;meetings;Memory;Mental Depression;Methods;mild cognitive impairment;Motivation;neglect;Nerve Degeneration;Neurofibrillary Tangles;Neurons;neuroprotection;neuropsychiatry;Nonpharmacologic Therapy;novel;older adult;Outcome Measure;Participant;Patients;performance tests;Phase;Physical activity;Physical Function;Physiological;Pilot Projects;placebo group;Placebos;Population;Prediction of Response to Therapy;Predictive Value;Prefrontal Cortex;prevent;primary outcome;Problem behavior;psychologic;Quality of life;Randomized, Controlled Trials;repetitive transcranial magnetic stimulation;Research;Research Design;response;Risk;Self Care;Series;Short-Term Memory;Societies;Telephone;Testing;tool;Transcranial magnetic stimulation;Translating;transmission process;treatment effect;treatment-resistant depression;Variant;Veterans

PROJECT_TITLE: Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: ORONO

ORG_NAME: UNIVERSITY OF MAINE ORONO

ORG_STATE: ME

PHR: Narrative The negative regulation of receptor signaling is important to prevent cancer and heart disease. We propose to use the yeast pheromone response as a model system for receptor signaling to understand how localization of the regulator of G-protein signaling (RGS) is changed over time and how that impacts the cellular response to extracellular signal.

PI_NAMEs: KELLEY, JOSHUA BRIAN (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Alanine;Aspartic Acid;base;Binding;Biochemistry;Biological Models;Cell Communication;Cell Physiology;Cells;Co-Immunoprecipitations;Coupled;Cytoskeleton;Cytosol;Data;desensitization;Detection;Diffuse;Disease;Endocytosis;Environment;Eukaryota;Event;extracellular;fluorescence imaging;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;genetic approach;Growth;GTP-Binding Protein Regulators;GTP-Binding Proteins;Guanosine Triphosphate Phosphohydrolases;Health;Heart Diseases;hormonal signals;Human;Image Analysis;immune function;interest;Ligands;live cell imaging;Lysine;Malignant Neoplasms;Mediating;Microfluidic Microchips;mimetics;Modeling;Molecular;Morphogenesis;Mutagenesis;mutant;Mutation;Outcome;Output;Partner in relationship;Pathway interactions;pharmacologic;Pheromone;Pheromone Receptors;Phosphorylation Site;Physiological;polarized cell;Post-Translational Protein Processing;prevent;Process;Protein phosphatase;Proteins;ratiometric;receptor;receptor binding;Receptor Signaling;Regulation;response;RGS Proteins;Role;Signal Pathway;Signal Transduction;spatiotemporal;Structure;System;Testing;Time;tumor progression;yeast genetics;Yeasts

PROJECT_TITLE: Spatiotemporal control of RGS signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-B (81)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative  The cerebral cortex is instrumental to all human and animal cognition, ranging from sensation to decision making to movement. The complexity of cortical circuits is a major obstacle to both understanding cortical function as a whole and to treating maladies that might afflict it, including numerous neurological and psychiatric disorders. The proposed studies will reveal how cortical circuits interact to execute cortical computations, how these interactions are impaired by aging and neurodegeneration, and how we can noninvasively stimulate cortical circuits to galvanize the brain to fight against pathologies caused by aging and Alzheimer’s disease.

PI_NAMEs: PARK, JUNG MAN (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Affect;Age;age related;age related changes;aged;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Anatomy;Animals;Atrophic;Behavior;Behavioral;behavioral health;biophysical properties;Brain;Brain region;cell cortex;cell type;cerebral atrophy;Cerebral cortex;Cognition;Cognitive;cognitive ability;Complex;convolutional neural network;Cortical Synchronization;Decision Making;density;Development;Discrimination;discrimination task;Disease;effective intervention;Electrodes;Equilibrium;Esthesia;extracellular;falls;fighting;Fingers;Functional disorder;Functional impairment;Generations;Genes;Head;Health;healthy aging;Human;Impairment;improved;in vivo;Individual;Injury;insight;Interneurons;Learning;Lesion;life span;Massachusetts;Mediating;Membrane;Mental disorders;middle age;Motor;Motor Cortex;mouse model;Movement;Mus;Nerve Degeneration;Nervous System;Nervous System Disorder;neural;novel therapeutics;older adult;optogenetics;Organ;Output;pathological aging;Pathology;Pathway interactions;Patients;Performance;Physiology;postnatal;Predisposition;prevent;Progress Reports;Property;Proprioception;Quality of life;Recurrence;Resolution;Retina;Role;Sensorimotor functions;Sensory;sensory cortex;sensory discrimination;Somatosensory Cortex;Speed;Stream;Structure;Synapses;synaptic pruning;System;targeted treatment;Task Performances;Technology;Texture;Thalamic structure;Training;Universities;Vibrissae;Work

PROJECT_TITLE: Plasticity of cortical circuits in health, aging, and Alzheimer's disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Cognitive deficits associated with aging, traumatic brain injury (TBI), and neurodegenerative diseases pose major challenges to healthcare systems throughout the world. To facilitate successful aging, we need effective methods for early detection of neurodegeneration and for monitoring cognitive function. Here, we propose to develop continuous and objective estimates of cognitive changes derived computationally and unobtrusively from smartphone-based data (location information, application use patters, and motor interactions with touchscreens, context inferences).).

PI_NAMEs: KOS, MACIEJ RAFAL (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Accounting;accurate diagnosis;Adult;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Android;Attention;Biological Markers;Brain imaging;care providers;Caregivers;Caring;Cellular Phone;Characteristics;Clinical;Clinical assessments;Clinical Trials;Cognition;Cognitive;cognitive change;Cognitive deficits;cognitive function;Cognitive Science;cost;Cross-Sectional Studies;Data;Dementia;Development;Diagnosis;Digital biomarker;Early Diagnosis;Ecological momentary assessment;Effectiveness;Frequencies;Functional disorder;Goals;Health;health data;Healthcare Systems;Impaired cognition;improved;Individual;Informed Consent;instrumental activity of daily living;Location;Longitudinal Studies;Measures;Methods;mHealth;middle age;mild cognitive impairment;mobile app development;mobile application;mobile computing;Modeling;Monitor;Motor;Names;Nature;Nerve Degeneration;Neurocognitive;neurocognitive disorder;Neurodegenerative Disorders;Neurology;Neuropsychology;novel strategies;older adult;open source tool;Participant;Patients;Pattern;Phase;Postdoctoral Fellow;Psychometrics;Psychomotor Performance;Recording of previous events;Reporting;Research;Research Personnel;Research Project Grants;Selection for Treatments;Services;Short-Term Memory;Signal Transduction;Social Interaction;socioeconomics;software development;Speed;System;TBI Patients;Testing;time use;touchscreen;Training;Transportation;Traumatic Brain Injury;Validation;Visit;walking speed;web site;young adult

PROJECT_TITLE: Unobtrusive and continuous monitoring of cognitive changes using smartphones


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Our Research Center will leverage our extensive lung tissue biobank and expertise in multi-omics, induced pluripotent stem cells (iPSC) differentiation, and bioinformatics to construct a multi-scale map of the developing acinar and alveolar structures for the normal human lung and those with childhood interstitial lung disease (chILD). We will establish new technologies, experimental protocols, and computational approaches to support the pulmonary research community and develop AI-powered analysis of complex multi-omic data to identify gene regulatory networks underlying normal lung formation and disease-related tissue remodeling. We will also generate patient-derived iPSCs to model and interrogate disease pathogenesis. LungMAP 2 - Project Narrative-v7

PI_NAMEs: CHEN, JICHAO ;WIKENHEISER-BROKAMP, KATHRYN ANN;XU, YAN  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Acceleration;Acinus organ component;Address;Age;Alveolar;Alveolar Duct;Alveolar sac;Alveolus;Artificial Intelligence;Atlases;biobank;Bioinformatics;Biology;candidate identification;candidate marker;causal variant;cell type;Cells;Cellular Structures;Child;Childhood;Chromosome Mapping;Chronic Obstructive Pulmonary Disease;Communities;Complex;confocal imaging;Confocal Microscopy;curative treatments;Cystic Fibrosis;Data;Data Coordinating Center;Development;Diffuse;directed differentiation;Disease;Disease Progression;Distal;Electron Microscopy;Endothelium;Epithelium;Exclusion;FOXF1 gene;gene regulatory network;generative artificial intelligence;Genes;Genetic;Genetic Transcription;genetic variant;genome sequencing;genome wide association study;Genomics;Guidelines;Heterogeneity;Human;human disease;human tissue;Image;In Vitro;in vivo;induced pluripotent stem cell;Infant;Infection;Infrastructure;injury and repair;insight;Interstitial Lung Diseases;life span;Link;Literature;Lung;lung development;Lung Diseases;Maintenance;Maps;Medical;member;Mesenchymal;microscopic imaging;Modeling;Molecular;molecular phenotype;Morphogenesis;mouse model;Multiomic Data;multiple omics;Mutant Strains Mice;Mutate;Mutation;neonatal lung disease;new technology;Organoids;Pathogenesis;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phase;pluripotent stem cell differentiation;power analysis;Productivity;Proteomics;Protocols documentation;Publications;Research;Resolution;sample collection;Series;Signal Transduction;single cell genomics;single nucleus RNA-sequencing;Structure;Structure of parenchyma of lung;Structure of respiratory bronchiole;Subcellular structure;surfactant;symptom management;Technology;Time;tissue mapping;Tissues;tool;Transcriptional Regulation;transcriptomics;Variant;web portal;whole genome

PROJECT_TITLE: A mechanistic 3D AI-powered map of genetic chILD

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (M1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Hematology

ORG_CITY: ROCHESTER

ORG_DEPT: BIOLOGY

ORG_NAME: OAKLAND UNIVERSITY

ORG_STATE: MI

PHR: Narrative Platelets play important roles in health and disease. We have identified a platelet protein, called TREM Like transcript (TLT-1), that mediates leukocyte escape from the blood vessel without causing vessel damage. TLT-1 has the potential to be developed into therapeutic interventions where the immune system triggers hemostatic mechanisms such as cardiovascular disease and acute lung injury

PI_NAMEs: WASHINGTON, A. VALANCE (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acute Lung Injury;Adhesions;Affect;Alpha Granule;Binding;Blood Platelets;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;Cell surface;Cells;Circular Dichroism;Coagulation Process;Cues;Cytoplasmic Granules;Cytoplasmic Tail;Data;Disease;Disease Outcome;Edema;Endothelial Cells;Endothelium;Evaluation;Fibrinogen;Goals;Health;Hemorrhage;Hemostatic Agents;Hemostatic function;Immune system;Immunofluorescence Immunologic;Immunotherapy;improved;Individual;Inflammation;Inflammatory;insight;interest;Laboratories;Leukocytes;Ligands;Lipid Bilayers;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Megakaryocytes;Modeling;Mutate;Myelogenous;Outcome;Pathway interactions;Phospholipids;Phosphorylation;Phosphorylation Site;Platelet Activation;platelet function;Play;Process;Protein Engineering;Proteins;rab GTP-Binding Proteins;receptor;Regulation;RNA Splicing;Role;Sepsis;Series;Serine;Signal Transduction;Site;small molecule;Structure;Surface;System;Tail;Text;Therapeutic;therapeutic target;Thrombosis;Time;trafficking;Transcript;Universities;Variant;wound healing

PROJECT_TITLE: TLT-1 intracellular function

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pain Research;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: Auburn

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Project Narrative The proposed research tests mediating and moderating processes underlying racial discrimination’s harmful effect on sleep, a critical restorative process implicated in numerous health problems including immune functioning, heart disease, psychopathology, and suicidality. By investigating factors underlying racism’s effect on sleep, the proposed work offers new insights into pressing race- related health disparities generally and inequities in the far-reaching restorative process of sleep specifically. In addition to its scientific contribution, the proposed work will also offer undergraduate and graduate students cutting edge training in research design, survey methods and actigraphy, data analysis, and the development of research presentations and publications certain to improve their professional trajectories.

PI_NAMEs: KUNSTMAN, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: actigraphy;Address;Affect;African;Alabama;American;American Heart Association;Anxiety;Arousal;Awareness;Belief;Black American;Black Populations;Black race;caucasian American;Communication;Communities;Community Health Education;Corrosion;Corrosives;cost;Darkness;Data Analyses;Discrimination;Disparity;Ecological momentary assessment;Emotional;Emotions;empowerment;Ensure;Equity;Event;experience;Feeling;Fostering;Future;graduate student;Health;health determinants;health disparity;health goals;health inequalities;Heart Diseases;immune function;improved;in vivo;Individual;Individual Differences;Inequity;innovation;insight;Institute of Medicine (U.S.);Institution;Intervention;Life;Link;Lip structure;Measures;Mediating;Mediator;Mental Depression;Mental Health;Methods;Minority Groups;National Heart, Lung, and Blood Institute;National Institute on Minority Health and Health Disparities;negative affect;neglect;Outcome;Pain;Participant;Patient Self-Report;Persons;Phenotype;physical conditioning;Physiological;poor sleep;Process;Productivity;prototype;Psychological Factors;Psychopathology;Public Health;Publications;Race;racial discrimination;racism;Reporting;Research;research and development;Research Design;Risk Factors;rumination;Sampling;Skin;Sleep;Sleep Disorders;Sleep disturbances;social;social factors;social relationships;societal costs;Stereotyping;Stress;stressor;suicidal;Survey Methodology;Testing;Time;Training;Trust;undergraduate student;underserved minority;Validation;vigilance;Work

PROJECT_TITLE: Using Event Momentary Assessment and Actigraphy to Investigate Mediating and Moderating Processes of Discrimination's Negative Effect onSleep

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: ALBANY

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: ALBANY COLLEGE OF PHARMACY

PHR: Project Narrative: The potential of Francisella tularensis, a Category A bioterror agent to cause severe infection is due to its ability to suppress the host’s innate immune system. The proposed studies will explore how Francisella evades the host innate immune responses. Defining the molecular mechanism(s) of suppression of innate immunity will be an essential first step towards the development of immunotherapeutic, as well as effective vaccine strategies to combat this fatal disease.

PI_NAMEs: MALIK, MEENAKSHI  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: AIM2 gene;Bioterrorism;bioweapon;Categories;Cell Death Induction;Cells;Cessation of life;Classification;combat;Country;cytokine;Cytoplasm;Development;Disease;Excision;Family;Francisella;Francisella tularensis;Funding;Generations;Growth;Host Defense Mechanism;Hour;human disease;Immune response;Immunotherapeutic agent;improved;Incidence;Infection;Inflammasome;Inflammatory;Innate Immune Response;Innate Immune System;Ligands;Link;Literature;Macrophage;Manuscripts;marenostrin;Mediating;Mitochondria;Mitochondrial DNA;Molecular;Multiprotein Complexes;Natural Immunity;pathogen;Pathway interactions;Pattern;Peer Review;Preparation;prevent;Process;Production;programs;Publishing;Pulmonary tularemia;Reactive Oxygen Species;receptor;Reporting;Repression;Research;response;Role;Stress;Students;Toll-like receptors;training opportunity;Tularemia;undergraduate student;vaccine strategy;vaccine-induced immunity;Virulence

PROJECT_TITLE: Repression of inflammasome by Francisella tularensis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (09)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEWARK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: NEW JERSEY INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: Project Narrative This project aims to develop deep learning methods for analysis of single-cell RNA sequencing data, which have been generated for investigating various biomedical problems. The novel deep learning methods are expected to offer more insights into each of the biomedical areas represented by the various data sets. The research project will stimulate the interests of undergraduate trainees so that they can consider a career in the biomedical sciences.

PI_NAMEs: WEI, ZHI  (contact)

PROGRAM_OFFICER_NAME: PILLAI, AJAY

PROJECT_TERMS: adaptive learning;Address;Architecture;Area;autoencoder;Awareness;Bayesian Modeling;Binomial Model;Bioinformatics;Biological;biological systems;Cancer Center;career;Categories;Cells;Charge;Collaborations;Collection;Complex;computer program;computer scientist;computerized tools;Computing Methodologies;Data;Data Analyses;Data Set;deep learning;deep learning model;deep neural network;Dependence;design;Detection;Development;dimension reduction;Documentation;Dropout;Event;experimental study;feature selection;Frequencies;Funding;generative models;Genes;genomic data;Goals;Grant;Hair follicle structure;Human;Hybrids;improved;insight;interest;Knowledge;Learning;learning algorithm;machine learning method;medical schools;Melanoma;Methodology;Methods;Modeling;Natural regeneration;novel;Outcome;Paneth Cells;Pennsylvania;Performance;Phenotype;Procedures;Process;Program Efficiency;programs;recruit;Regulation;Research Personnel;Research Project Grants;Science;Selection Criteria;single cell analysis;single-cell RNA sequencing;Specific qualifier value;Statistical Methods;statistics;Students;task analysis;Techniques;The Wistar Institute;Time;Transcript;transcriptome sequencing;undergraduate student;Universities;Variant;Work

PROJECT_TITLE: Deep Learning Methods to Integrate Biological Information for Analysis of Single-cell RNAseq Data

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Nutrition;Rare Diseases

ORG_CITY: NORMAL

ORG_NAME: ILLINOIS STATE UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE Production of the type IV mannose-sensitive hemagglutinin (MSHA) pilus is essential for biofilm formation and environmental survival of the pandemic cholera pathogen Vibrio cholerae, yet is detrimental to host colonization and establishment of infection. These proposed studies will define a novel msh transcriptional regulatory mechanism that facilitates the transition of V. cholerae from colonization of the environment to the host. Information obtained from these studies could be leveraged to the development of new strategies to prevent either environmental persistence or host pathogenesis of V. cholerae.

PI_NAMEs: FLOYD, KYLE A (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Acids;Acyl Coenzyme A;Address;attenuation;Bacteria;bacterial community;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Assay;Carbon;Cell surface;Cells;Cholera;Computer Analysis;contaminated water;Data;Development;Diet;DNA;Electrophoretic Mobility Shift Assay;Enhancers;Environment;fatty acid metabolism;fatty acid supplementation;Fluorescence-Activated Cell Sorting;Food Contamination;Gastrointestinal Diseases;Genetic;Genetic Transcription;Goals;Hemagglutination;Hemagglutinin;host colonization;human pathogen;Infection;Ingestion;Innate Immune Response;Libraries;Life;Life Cycle Stages;Ligands;long chain fatty acid;Mannose;Mediating;Methodology;Microbial Biofilms;Microscopy;Modeling;Molecular;Motility;mutant;novel;Operon;Outcome;pandemic disease;pathogen;Pathogenesis;pi bond;Pilum;polymicrobial biofilm;prevent;Production;promoter;Promoter Regions;Proteins;Public Health;Regulation;Regulatory Pathway;Reporter;Repression;Research;Role;Supplementation;Surface;Vibrio cholerae;Vibrio cholerae infection;Virulence;Visualization;Work

PROJECT_TITLE: Regulation of the Vibrio cholerae MSHA Pilus Drives Host Colonization and Pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-V (81)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: MUNCIE

ORG_NAME: BALL STATE UNIVERSITY

ORG_STATE: IN

PHR: This project will study frontal temporal dementia (FTD), a devastating neurodegenerative disease without a cure, commonly caused by a mutation in C9ORF72, which causes the production of toxic RNA and proteins leading to neuronal death. This research will determine the roles of a major G-quadruplex helicase, DHX36, in stress responses and genomic integrity in C9 FTD (and related C9 ALS disease), and will also initiate the development of a novel therapeutic strategy targeting DHX36 in C9 ALS/FTD, while integrating dozens of students into cutting edge, biomedically-relevant research.

PI_NAMEs: SMALDINO, PHILIP J (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Accounting;Age;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Biochemistry;biological adaptation to stress;Brain;C9ALS;C9FTD;C9ORF72;Cell Line;Cell Nucleus;Cells;Cellular Stress;Chromosomes;Chronic stress;Collaborations;Cytoplasm;Data;Dementia;Development;Diagnosis;Dipeptides;Disease;DNA;DNA Damage;Educational process of instructing;Enrollment;Enzymes;experience;experimental study;Frontotemporal Dementia;Funding;Future;G-Quartets;Genetic;genome integrity;Genomic Instability;graduate student;helicase;Human;human disease;Immunofluorescence Immunologic;Impairment;improved;in vivo;innovation;Journals;knock-down;Knock-out;Link;Mediating;Michigan;Modeling;Molecular;Molecular Conformation;Molecular Disease;mouse model;multidisciplinary;Mus;Mutation;Nature;Nerve Degeneration;nerve stem cell;Neurodegenerative Disorders;neuron loss;Neurons;new therapeutic target;novel;novel therapeutic intervention;Nuclear;nucleocytoplasmic transport;Onset of illness;Pathogenesis;Pathogenicity;Patients;preservation;prevent;Production;protective effect;Proteins;proteotoxicity;Publishing;Reporter;Research;Research Personnel;RNA;RNA Folding;Role;Stress;stress granule;stress reduction;Structure;Students;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;Time;Training;Transgenic Mice;Translations;treatment strategy;undergraduate research experience;undergraduate student;United States National Institutes of Health;Virginia;Work

PROJECT_TITLE: Implicating the major G-quadruplex helicase, DHX36, as a novel pathogenic modifier of C9ORF72 frontal temporal dementia

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative COVID-19 represents an unprecedented, multisystem shock to children’s educational and family environments, borne disproportionately by children from low-income families, those who are Latinx and Black, and children with special needs. Yet, little existing or emerging research is focusing on these subgroups of children, nor is the extant knowledge base able to identify pre-pandemic dimensions of child functioning or specific features of children’s family, school, and peer contexts, including culturally-embedded protective features, that can serve as effective targets for pandemic relief and recovery efforts aimed at restoring strong developmental growth as children recover from educational and family disruptions during school closures, and continued family disruptions after schools reopened. This application provides a unique opportunity to address these shortcomings by leveraging an existing longitudinal study of exclusively low-income children, with large subgroups of Latinx (including Spanish-speaking ELLs) and Black children, and children with special needs, first observed as preschoolers years prior to the pandemic and who will enter pre-adolescence as COVID-19 continues, to examine the moderating role of (1) children’s pre-existing strengths and vulnerabilities and (2) post-school-reopening family, school, and peer contexts as they explain effects of pandemic-induced educational and family disruption during the period of school closures, and continued family disruption following school reopening, on children’s immediate and longer-term recovery of cognitive/academic and self- regulatory skills, social functioning, and emotional/mental health.

PI_NAMEs: JOHNSON, ANNA D. (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: Address;Adolescence;Adolescent;Affect;Black race;Child;cognitive recovery;Complex;COVID-19;COVID-19 impact;COVID-19 pandemic;current pandemic;Data;Development;Dimensions;Disasters;Education;Emotional;emotional distress;Environment;Family;fifth grade;first grade;Future;future pandemic;Growth;improved;Individual Differences;Knowledge;knowledge base;Latinx;Learning;Longitudinal Studies;Low income;lower income families;Measurement;Measures;Mental Health;ninth grade;Nursery Schools;Outcome;pandemic disease;pandemic impact;peer;Personal Satisfaction;Population;pre-pandemic;preadolescence;Predisposition;Preparation;protective factors;Public Health;Quarantine;Race;racial minority;Recovery;Research;resilience;response;Risk;Role;Sampling;school closure;school reopening;Schools;Shock;skills;Social Functioning;Social isolation;Spanish;Special needs;Specific qualifier value;Students;Subgroup;System

PROJECT_TITLE: Succumbing, Surviving, and Thriving: The Development of Low-Income Students in the Long Shadow of COVID-19

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome

ORG_CITY: SWARTHMORE

ORG_NAME: SWARTHMORE COLLEGE

PHR: PROJECT NARRATIVE The goal of this project is to understand the basic function of specific DNA sequences found near chromosomal centromeres – constricted regions to which spindle fibers attach, enabling duplicated chromosomes to segregate to opposite poles of a dividing cell. Tandemly repeated DNA sequences, called satellites, reside within these regions and their sequences have only recently been fully assembled, which allows for their full characterization for the first time. In cancer cells, these satellite sequences are misregulated such that they become expressed, and we aim to understand both their sequence diversity and consequences of their expression.

PI_NAMEs: CARONE, DAWN M. (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Adopted;Award;Binding;Bioinformatics;Biomedical Research;Bulla;cancer cell;career;Cell division;Cell Line;Cell Nucleus;Cells;Centromere;chromosomal location;Chromosomes;Collaborations;constriction;Coupled;Cytogenetics;Cytology;Defect;differential expression;DNA;DNA Sequence;Ectopic Expression;epigenetic regulation;Fiber;Fibroblasts;functional genomics;Future;genetic regulatory protein;Genetic Transcription;Genome;Genome Mappings;genomic locus;Genomics;Goals;Heterochromatin;Human;Human Chromosomes;Human Genome;In Vitro;in vivo;Individual;innovation;Location;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Cell;Maps;Methyl-CpG-Binding Protein 2;micronucleus;Microscopic;Molecular;Nature;Normal Cell;Nuclear;Nuclear Protein;Nuclear Proteins;Nuclear RNA;Phenotype;Plants;Polycomb;Property;Proteins;Publications;Publishing;recruit;Regulation;Research;Research Personnel;Research Training;Resources;RNA;Satellite DNA;segregation;Sequence Analysis;Site;Structure;Supervision;Tandem Repeat Sequences;Techniques;telomere;Testing;Time;Tissues;tool;Training;Transcript;undergraduate student;Untranslated RNA;Variant;Work;Yeasts

PROJECT_TITLE: Functional Analysis of Locus-Specific Pericentric Satellite Expression


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Obesity

ORG_CITY: FARGO

ORG_NAME: NORTH DAKOTA STATE UNIVERSITY

ORG_STATE: ND

PHR: Attention and memory contributions to the maintenance of binge eating PROJECT NARRATIVE The proposed project is relevant to public health because it will advance our understanding of the factors that contribute to the maintenance of binge eating disorder, a debilitating condition that incurs increased risk of serious medical complications and death. A better understanding of what drives binge eating is expected to contribute to efforts aimed at improving treatments for this condition.

PI_NAMEs: JOHNSON, JEFFREY SCOTT (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Affect;Attention;attentional control;base;Behavior;Binge Eating;Binge eating disorder;biobehavior;Bulimia;Cessation of life;cognitive process;Control Groups;craving;Cues;Development;Diabetes Mellitus;Diagnostic;Eating;Eating Behavior;Eating Disorders;Ecological momentary assessment;Effectiveness;Electroencephalography;Environment;Exhibits;experience;Exposure to;Food;food consumption;food craving;Frequencies;Health;High Prevalence;Hunger;Impairment;improved;indexing;Individual;Information Storage;Intervention;Link;Maintenance;Measures;Mediating;Mediation;Medical;medical complication;Memory;memory process;Modeling;mortality;Motivation;neural;Obesity;Participant;Play;Predictive Factor;psychosocial;Public Health;Publishing;Recurrence;Regulation;Research;Research Design;Research Methodology;Resources;Risk;Role;Short-Term Memory;Symptoms;Testing;Time;tool;Treatment Efficacy;Treatment outcome;Weight

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Natural Products

ORG_CITY: MELBOURNE

ORG_DEPT: CHEMISTRY

ORG_NAME: FLORIDA INSTITUTE OF TECHNOLOGY

ORG_STATE: FL

PHR: One of the most critical issues in the drug discovery and development is a lack of reliable, efficient chemical synthesis methods. This proposal seeks to develop new methods to synthesize complex chiral hydrazines and amines in a single hand form with high efficiency from readily accessible starting materials.

PI_NAMEs: TAKENAKA, NORITO  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TITLE: Enantioselective Catalytic Chlorosilane Reactions

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: NORFOLK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OLD DOMINION UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The proposed project determines how adhesions that help cells stick to one another in solid tissues transmit forces from cell to cell as well as how these adhesions may be affected by the mechanical properties of cells around the adhesions. Attainment of the aims proposed in the project will enable a better understanding of key events in development as well as what disrupts tissue organization in diseases like cancer.

PI_NAMEs: MARUTHAMUTHU, VENKAT  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TITLE: Mechanoregulation of E-cadherin Adhesion


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Lung;Nanotechnology

ORG_CITY: STEPHENVILLE

ORG_NAME: TARLETON STATE UNIVERSITY

PHR: Metallic nanomaterials, including cobalt-based, are being designed and used for many biomedical applications. It is important to fully understand the fate and potential harm of these materials prior to use in the body, and for the safety of the fabrication scientists. This proposed study will greater help to understand the potential implications following chronic inhalation exposure to cobalt or cobalt-oxide nanoparticles.

PI_NAMEs: SPESHOCK, JANICE  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: 3-Dimensional;Acute;airway epithelium;artificial lung;Cell Culture System;Cell Culture Techniques;Cell Line;Cells;Chronic;Cobalt;Communication;cytotoxic;Data;design;Development;Dissociation;Dose;Endothelial Cells;Exposure to;fabrication;Fibroblasts;Fibrosis;First Generation College Students;Gases;Gene Expression;Goals;Gold;High Prevalence;Hour;Immune;Impairment;In Vitro;in vitro Model;in vivo;Inhalation;Inhalation Exposure;interest;Ions;Laboratories;Long-Term Effects;Lung;lung injury;Magnetism;Medicine;Membrane;metallicity;Metals;metatranscriptomics;Microfluidics;Microscopy;Modeling;Morphology;nanoGold;nanomaterials;nanoparticle;Nanotechnology;Nucleic Acids;Organism;Oxides;particle;Phenotype;Predisposition;Property;Proteins;Pulmonary Fibrosis;respiratory;Respiratory System;response;Rodent Model;Rural;Safety;Science;Scientist;Silver;Structure;Technology;Testing;Tissue-Specific Gene Expression;Toxicology;trafficking;transcriptome sequencing;transcriptomics;undergraduate student;Universities

PROJECT_TITLE: A meta-transcriptomic assessment of chronic respiratory exposure to cobalt-based nanomaterials using a microfluidic three-dimensional lung model for determining potential predisposition to lung injury

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: The proposed research is relevant to public health, because a sustainable technology will be developed for the passive bioremediation of complex mixtures of groundwater contaminants, including chlorinated solvents and 1,4-dioxane via aerobic cometabolism. The co-encapsulation of pure cultures of bacteria along with slow release compounds in hydrogels beads has the potential to lower costs and achieve high treatment efficiencies. The beads can be used to treat a broad range of contaminants and in many different platforms, including permeable reactive barriers.

PI_NAMEs: HYMAN, MICHAEL R.;ROCHEFORT, WILLIE ERNEST;SEMPRINI, LEWIS  (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: 3-Dimensional;Aerobic;alcohol effect;Alcohols;Alkanes;anthropogenesis;Bacteria;Bioremediations;Carcinogens;Catabolism;Cells;Centers for Disease Control and Prevention (U.S.);Chloroform;Complex;Complex Mixtures;cost;Crosslinker;Development;Dichloroethylenes;Diffuse;Dimethylnitrosamine;Dioxanes;drinking water;Encapsulated;Enzymes;Ethylene Dichlorides;Ethylenes;Experimental Designs;experimental study;Formulation;gellan;Generations;Genome;Goals;ground water;Growth;Human;Hydrocarbons;Hydrogels;In Situ;interest;Label;Laboratories;large scale production;Life Cycle Stages;materials science;Measurement;Mechanics;Methods;Methylene Chloride;microbial;microorganism;Mixed Function Oxygenases;Modeling;N-nitrosodimethylamine;Output;Permeability;Physiological;Polymers;Process;Proteome;Proteomics;Public Health;Pump;remediation;Research;Rhodococcus;Sampling;scale up;screening;Site;Soil;Solvents;Starvation;Statistical Models;System;Techniques;Technology;Temperature;Test Result;Testing;Tetrachloroethylene;Toxic effect;Trichloroethanes;Trichloroethylene;United States;Validation;Vinyl Chloride;volatile organic compound;Water Supply;Work

PROJECT_TITLE: Development of Passive and Sustainable Cometabolic Systems to Treat Complex Contaminant Mixtures by Encapsulating Microbial Cultures and Slow Release Substrates in Hydrogels


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: PENSACOLA

ORG_NAME: UNIVERSITY OF WEST FLORIDA

PHR: Project Narrative This project aims to use phage display to develop a sensitive and specific biomarker array based on post-translational modifications of the tau protein associated with Alzheimer’s disease using cerebrospinal fluid and blood.

PI_NAMEs: GUTTMANN, RODNEY P (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Academic Research Enhancement Awards;accurate diagnosis;Address;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Bacteriophages;Binding;Biochemical;Biological Assay;Biological Markers;biomarker identification;biomarker panel;Biomedical Research;Blood;Blood Tests;blood-based biomarker;career;Cerebrospinal Fluid;Clinical assessments;clinical diagnosis;Clinical Trials;cohort;Data;Dementia;detection assay;diagnostic accuracy;Disease;Disease Progression;early detection biomarkers;Early Diagnosis;Enzyme-Linked Immunosorbent Assay;Epitopes;Equipment;Florida;Funding;Future;Glycine;glycosylation;Goals;Grant;Image;improved;In Vitro;innovation;Institution;interest;Libraries;Link;Measurable;Measures;Methods;Modification;Molecular Conformation;Monitor;Pathologic;Peptides;Phage Display;Post-Translational Protein Processing;prevent;Procedures;Process;protein expression;Proteins;Qualifying;Research;research clinical testing;Science;screening;Sensitivity and Specificity;Signal Transduction;specific biomarkers;Sumoylation Pathway;synthetic peptide;tau aggregation;tau Proteins;tau-1;Testing;Therapeutic;undergraduate student;Universities;Work

PROJECT_TITLE: Identifying biomarkers for the early detection of Alzheimer's disease using phage display

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_NAME: UNIVERSITY OF MISSOURI-ST. LOUIS

ORG_STATE: MO

PHR: Project Narrative Despite their life-saving effectiveness, medications for opioid use disorder are often the subject of stigmatizing attitudes and actions, which has reduced their use in treatment and recovery settings. This form of stigma, known as Intervention Stigma, has been investigated using qualitative research, but existing methods to measure it are lacking, which prevents the development and testing of effective strategies to reduce stigmatizing beliefs and policies. This project will develop a measure of Intervention Stigma tailored for decision makers, healthcare personnel, and the general public, and will assess differences in endorsement and experience of Intervention Stigma among people with lived experience with opioid use disorder and those from racially minoritized groups.

PI_NAMEs: WINOGRAD, RACHEL  (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: addiction;Address;Agonist;Anecdotes;antagonist;Area;Attitude;Belief;Buprenorphine;Client;Clinical;cognitive interview;Collaborations;community collaboration;Credentialing;Delphi Study;Delphi Technique;Development;Dimensions;Drug usage;Education;Effectiveness;Elements;Environment;Evaluation;experience;Formulation;Foundations;Future;General Population;Goals;graduate student;Health Personnel;improved;Individual;Infrastructure;Injectable;Injections;interest;Intervention;Knowledge;Left;Life;Lived experience;Measurement;Measures;Medical;medical specialties;medication for opioid use disorder;member;Methadone;Methods;Missouri;Modality;Modeling;Modernization;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Naltrexone;Nature;next generation;Opioid agonist;Opioid Antagonist;opioid use disorder;Oral;Outcome;overdose death;Pattern;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Policies;Population;Population Group;prevent;programs;Property;psychologic;Psychometrics;psychosocial;Qualitative Research;Race;racial identity;racial minority population;Recovery;Regimen;Research;Research Infrastructure;Research Personnel;response;Risk;Role;Route;Sampling;Science;Scientist;social stigma;Stigmatization;Structure;Subgroup;Substance Addiction;substance use;substance use treatment;System;systematic review;Techniques;Testing;Training;Training and Infrastructure;undergraduate student;Uninsured;United States;Universities;Work

PROJECT_TITLE: Opioid Use Disorder Pharmaceutical Treatments: Investigating a Model and Measure of Intervention Stigma toward Medication (OPTIMISM)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics

ORG_CITY: HOUGHTON

ORG_NAME: MICHIGAN TECHNOLOGICAL UNIVERSITY

PHR: Project Narrative The main goal of this proposal is to elucidate is to elucidate how histone demethylases (KDMs) perform catalysis of histone substrates containing large alkyl groups compared to their standard methylated substrate regarding the primary substrate binding, dioxygen transport and binding, and their diverse reaction mechanisms.

PI_NAMEs: CHRISTOV, CHRISTO ZHIVKOV (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Academic Research Enhancement Awards;Active Sites;Affect;alkyl group;alpha ketoglutarate;Award;Basic Science;Binding;Binding Sites;Biochemistry;Bioinorganic Chemistry;Biological Process;cancer genetics;Catalysis;Chemicals;Complex;Computer Models;Dealkylation;demethylation;design;Dioxygen;disease diagnosis;Distant;Drug Design;electronic structure;enzyme substrate;Enzymes;epigenetic drug;Epigenetic Process;epigenetic regulation;Eukaryotic Cell;experience;experimental study;Foundations;Genetic Diseases;geometric structure;Goals;histone demethylase;Histones;Human;Hydrogen Bonding;Hydroxylation;inhibitor;insight;Link;Lysine;Methods;methyl group;Methylation;Mission;Modernization;Molecular;Motion;National Institute of General Medical Sciences;Nature;novel;Other Genetics;oxidation;Pathologic Processes;Pharmaceutical Preparations;Positioning Attribute;prevent;Prevention;Process;Proteins;Reaction;Research;Rotation;Site;Specificity;Structure;Substrate Interaction;Substrate Specificity;synergism;Techniques;Testing;undergraduate student;United States National Institutes of Health

PROJECT_TITLE: Understanding Catalytic Mechanisms of Human Non-Heme Fe(II) and 2-Oxoglutarate-Dependent Histone Demethylases

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: BAYAMON

ORG_NAME: UNIVERSIDAD CENTRAL DEL CARIBE

ORG_STATE: PR

PHR: Narrative: These studies will elucidate the roles of polyamines as endogenous glial cell molecules for extracellular signaling between glia and neurons in physiological and pathological situations. The results will provide important information for future efforts to understand and minimize neuronal damage during neurocognitive disorders, epilepsy and ischemia. Furthermore, the proposed studies should answer current critical questions regarding polyamine function in human CNS diseases, as well as lay the foundation for future work aimed at manipulating these processes therapeutically.

PI_NAMEs: SKATCHKOV, SERGUEI N (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Acetylation;Address;Adult;Affect;Affinity;Aging;Alzheimer's Disease;AMPA Receptors;Area;Astrocytes;Biological Markers;Biosensor;Biotinylation;Blood;Blood Vessels;Brain;Brain Diseases;Brain Injuries;Brain Ischemia;Central Nervous System;Central Nervous System Diseases;Connexin 43;Data;Dementia;dietary;Disease;Environment;Epilepsy;extend lifespan;extracellular;Foundations;Funding;Future;gamma-Aminobutyric Acid;gap junction channel;Gap Junctions;Giant Cells;glial activation;Goals;graduate student;Hippocampus;HIV;HIV-associated neurocognitive disorder;Homeostasis;Human;Huntington Disease;immunocytochemistry;Impaired cognition;Individual;interest;Interneuron function;Interneurons;Ischemia;knock-down;Knowledge;Literature;Longevity;Lymphocyte;Measures;Mental disorders;Morbidity - disease rate;mortality;Nerve Degeneration;neurocognitive disorder;Neuroglia;Neurologic;Neurons;neuroprotection;neurotoxicity;neurotransmission;novel;PARK9 gene;Parkinson Disease;Patch-Clamp Techniques;Pathologic;Pathology;Pathway interactions;Physiological;Physiology;Play;Polyamines;postsynaptic;Potassium Channel;Process;Public Health;Publishing;receptor;Research;response;Retina;Risk;RNA Binding;Role;Scheme;sensor;Signal Transduction;Small Interfering RNA;Source;Spermidine;Spermine;Stroke;Synapses;Syndrome;Therapeutic;tool;transmission process;Trauma;uptake;Viral;Visualization;Western Blotting;Work

PROJECT_TITLE: Glial Cells and Polyamine Signaling in the Central Nervous System

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: Bethesda

ORG_NAME: ASSOCIATION /PUBLIC HEALTH LABORATORIES

ORG_STATE: MD

PHR: Project Narrative The purpose of this proposal from the Association of Public Health Laboratories (APHL) is to support and enhance the capabilities of state human and animal food (HAF) testing laboratories that engage in surveillance and response activities associated with foodborne hazards, including foodborne outbreak investigations. APHL will build a competent HAF Laboratory workforce, plan and host conferences related to LFFM disciplines, the GenomeTrakr network, and NARMS, provide direct technical assistance to non-FDA funded HAF laboratories, maximize HAF laboratory participation in the GenomeTrakr network including development of the bioinformatics workforce, and promote information sharing between strategic partners. Leveraging our experience will better position FDA to work in partnership with state and local authorities to build an Integrated Food Safety System and achieve national public health goals.

PI_NAMEs: SHEA, SHARI  (contact)

PROGRAM_OFFICER_NAME: CHRYSOGELOS, CHRISTINA

PROJECT_TITLE: Building an Integrated Laboratory System to Advance the Safety of Human and Animal Food

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 ORA-J (2)]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Data Science;Genetics;Human Genome;Prevention

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: NARRATIVE Autoimmune and immune-mediated diseases affect ~10% of the total population and are strongly inﬂuenced by genetic risk factors. These diseases severely affect the quality of life and can lead to fatality in their advanced stages. Early diagnosis and intervention in the preclinical phase before the diseases fully develop are critical for slowing down the progression, mitigating symptoms, and improving the quality of life. Developing software tools to understand the genetic risk factors that affect the progression from preclinical phase to disease states is of great public health relevance.

PI_NAMEs: LIU, DAJIANG  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Acceleration;accurate diagnosis;Affect;Antigen Presentation;Antinuclear Antibodies;Apoptosis;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;biobank;Biological Markers;biomarker discovery;case control;Case/Control Studies;causal variant;cell type;Clinical;cohort;comorbidity;Computational Biology;Computer software;cytokine;Data;data ecosystem;Data Set;Dedications;Development;Diagnosis;Diagnostic;diagnostic criteria;Disease;Disease Progression;disorder risk;Early Diagnosis;Early Intervention;Electronic Health Record;FAIR principles;Family;Family health status;Family member;General Population;Genetic;genetic association;Genetic Models;genetic risk factor;genetic signature;genetic variant;genome wide association study;Genomics;Heritability;Human;Human Genetics;Immune;improved;Individual;insight;interest;Intervention;Knowledge;Lupus;Mediating;Medicine;Methods;Modeling;Molecular;Multiomic Data;multiple omics;National Institute of Allergy and Infectious Disease;novel;novel therapeutics;Patients;Phase;Phenotype;Population;pre-clinical;preclinical study;Production;Psoriasis;public health relevance;Quality of life;Recording of previous events;reduce symptoms;Research;Research Personnel;Rheumatoid Arthritis;Risk Factors;risk prediction;risk variant;Sample Size;Sampling;Series;seropositive;Sex Differences;side effect;single-cell RNA sequencing;Sjogren's Syndrome;software development;Software Tools;statistics;Sum;Symptoms;Systemic Lupus Erythematosus;T-Cell Activation;Testing;therapeutic development;tool;translational study;translational therapeutics;United States National Institutes of Health;Vitiligo

PROJECT_TITLE: Methods and tools to integrate multi-omics datasets to understand preclinical autoimmune and immune-mediated diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SB-X (M1)]


NIH_SPENDING_CATS: Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

PHR: NARRATIVE The current pipeline of talent is insufficient to improve diversity in the scientific workforce in diabetes and metabolic diseases research. The Joslin-Beth Israel Deaconess Medical Center Post-bac Program in Diabetes and Metabolism will recruit recent post-baccalaureates and provide them with the scientific, technical, and professional skills they will need to pursue doctoral degrees and the inspiration to dedicate their talents for prevention, treatment, and cure of diabetes and related metabolic disorders. By partnering with the Biomedical Sciences Career Program, University of Massachusetts Amherst, and Harvard College and by leveraging Handshake, a well-established online job-posting platform, we will identify and recruit diverse cohorts of post- bac participants to our program.

PI_NAMEs: SCHAFFER, JEAN E. (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Address;Biological Sciences;Biomedical Research;Boston;Breathing;broadening participation research;career;career development;career preparation;Clinical Research;cohort;college;Communities;Creativeness;Critical Thinking;Data Analyses;Decision Making;Dedications;Degree program;Development;Diabetes Mellitus;disadvantaged background;Disparity population;Diverse Workforce;Doctor's Degree;Educational workshop;Effectiveness;Endocrinology;ethnic minority;experience;Experimental Designs;Fostering;Foundations;Functional disorder;Goals;improved;Individual;Israel;lectures;Lived experience;Massachusetts;Medical center;Mentors;Mentorship;Metabolic Diseases;Metabolism;Methodology;Natural Sciences;Nonprofit Organizations;Occupations;Oral;Participant;Physiology;Population;Postbaccalaureate;Prevention;Program Development;programs;racial minority;recruit;Research;responsible research conduct;Science;skills;Social Justice;socioeconomic disadvantage;success;Talents;Testing;Training;Underrepresented Populations;United States;Universities;Workplace;Writing

PROJECT_TITLE: Joslin-BIDMC Postbac Program in Diabetes and Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-W (M1)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Disability Research;Hearing Loss;Neurosciences;Radiation Oncology;Rare Diseases;Rehabilitation

ORG_CITY: ATLANTA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Communication disorders, including hearing loss, swallowing difficulty, and impaired speech, are common in head and neck cancer survivors. The proposed research aims to test novel methods of increasing compliance with ototoxicity monitoring and identify clinical predictors of poor speech and swallowing function in older head and neck cancer survivors. This K24 will also allow Dr. Schmitt to pursue additional training in patient-oriented research and train the next generation of clinician-scientists in otolaryngology.

PI_NAMEs: SCHMITT, NICOLE CHERIE (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: advanced disease;Aftercare;Age;Area;Assessment tool;atorvastatin;Audiology;Biometry;Cancer Center;Cancer Patient;Cancer Survivor;cancer therapy;cancer type;Caring;Cellular Phone;chemoradiation;Chemotherapy and/or radiation;Chronology;Cisplatin;Clinic;Clinical;Clinical and Translational Science Awards;clinical predictors;Clinical Trials Design;Collaborations;Combined Modality Therapy;Communication;Communication impairment;Computer software;Control Groups;Counseling;Data;Databases;Decision Making;Deglutition;Deglutition Disorders;design;Disease;Early Diagnosis;expectation;Extramural Activities;Faculty;Family;follow-up;frailty;functional outcomes;Funding;graduate student;group intervention;Head and Neck Cancer;head and neck cancer patient;health disparity;hearing impairment;Hearing Tests;high risk;Hour;Hyperlipidemia;Impairment;improved;Incidence;Individual;interest;Intervention;Interview;Larynx;Medical Ethics;Medical Students;Mental Depression;Mentors;Methodology;Methods;Monitor;multidisciplinary;National Institute on Deafness and Other Communication Disorders;next generation;novel;older adult;older patient;Operative Surgical Procedures;Otolaryngology;ototoxicity;Outcome;patient oriented;patient oriented research;Patients;personalized approach;Pharyngeal structure;Physicians;Predisposition;programs;Provider;Publishing;Qualitative Research;Quality of life;Radiation;Randomized;randomized placebo-controlled clinical trial;Randomized, Controlled Trials;Recovery;Regrets;Rehabilitation therapy;Research;Research Personnel;Research Project Grants;Research Training;sarcopenia;Schedule;Scientist;Screening procedure;Sensorineural Hearing Loss;shared decision making;Site;skills;Social isolation;Speech;Survival Rate;telehealth;Testing;Texture;Time;Training;training opportunity;treatment as usual;trial comparing;Visit;Vulnerable Populations;X-Ray Computed Tomography

PROJECT_TITLE: Patient Oriented Research in Communication and Swallowing Disorders

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Diabetes;Nutrition

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: The Minnesota Postbaccalaureate Research Education Programs in Diabetes, Endocrinology, and Metabolic Diseases Program (MN-PRIDE) fills a crucial gap at the University of Minnesota (UMN) by training the next generation of diverse researchers dedicated to addressing diabetes and its associated health issues. This endeavor is made possible through the collaboration of experienced faculty members known for their excellent mentoring and cutting-edge core facilities, creating an exceptional training program for our participants. The goal of the MN- PRIDE program is to help participants build a robust research portfolio, which will facilitate their smooth transition into research-focused doctoral degree (PhD, MD/PhD) programs, thus supporting their success in conducting research related to diabetes, endocrinology, and metabolic diseases.

PI_NAMEs: ALEJANDRO, EMILYN  (contact);CHOW, LISA SENYE

PROJECT_TERMS: Address;Admission activity;Advocacy;Affect;Authorship;Automobile Driving;Biochemistry;Biology;Biomedical Research;Biophysics;career;career development;Clinic;Collaborations;college;Communication;Communities;Competence;Complex;Core Facility;Data;Dedications;design;Development;Diabetes Mellitus;disadvantaged background;Disease;Diverse Workforce;Doctor of Philosophy;Doctor's Degree;doctoral student;Dropout;education research;Educational Status;Educational workshop;empowerment;Endocrinology;Ensure;Environment;Evaluation;Exercise;experience;Faculty;faculty mentor;Fees;Fostering;Future Generations;Genomics;Goals;Graduate Education;graduate school;graduate student;Growth;Health;Image;Individual;Inflammation;innovation;Instruction;Interdisciplinary Study;Interview;Journals;Knowledge;Laboratories;Leadership;Learning Skill;Link;Manuscripts;meetings;member;Mentors;Mentorship;Metabolic Diseases;Metabolism;Methods;Minnesota;Molecular Biology;next generation;Obesity;Participant;Pathway interactions;peer;peer coaching;Physiology;Positioning Attribute;Postbaccalaureate;posters;Process;Professional Competence;programs;Publications;Qualifying;Readiness;Research;Research Personnel;Research Project Grants;Resources;responsible research conduct;Rewards;Science;Scientist;Series;Shapes;skill acquisition;skills;Structure;success;Teacher Professional Development;Technical Expertise;Testing;tool;Training;Training Programs;undergraduate student;Universities;waiver;Writing

PROJECT_TITLE: Minnesota Postbaccalaureate Research Education Program in Diabetes, Endocrinology and Metabolic Diseases


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Acute Myeloid Leukemia (AML) is a blood cancer that carries poor prognosis. Thus, novel therapies are needed to cure these patients. Our group has discovered that a protein called EGFL7 promotes AML. Targeting this protein using an antibody is a promising new way to kill AML cells. In this application, we propose to elucidate how EGFL7 facilitates leukemia and to develop novel combination therapies for AML.

PI_NAMEs: DORRANCE, ADRIENNE M. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;angiogenesis;Antibodies;antileukemic activity;autocrine;Binding;Biology;Blast Cell;Blocking Antibodies;Blood;Bone Diseases;Bone Marrow;cell growth;Cell Line;Cell Physiology;Cells;Chromosome abnormality;Clinical;clinical development;cohort;Combined Modality Therapy;conditional knockout;Cytogenetics;Data;Disease;DNA Sequence Alteration;effective therapy;efficacy evaluation;endothelial stem cell;Epithelium;Exhibits;experimental study;Feedback;FLT3 gene;FLT3 inhibitor;Frequencies;Genetic;Goals;Growth;Growth Factor;Hematological Disease;Hematopoietic Neoplasms;In Vitro;in vivo;Knockout Mice;leukemia;leukemia initiating cell;leukemia treatment;Leukemic Cell;Leukemic Hematopoietic Stem Cell;leukemic stem cell;leukemic transformation;leukemogenesis;Malignant - descriptor;Malignant Neoplasms;Marrow;mesenchymal stromal cell;Messenger RNA;Modeling;Molecular;Monoclonal Antibodies;mouse model;mRNA Expression;Mus;Mutate;Mutation;Myelogenous;novel;novel therapeutics;paracrine;patient derived xenograft model;Patients;Phenotype;Physiological;Play;pre-clinical;preclinical study;Preleukemia;Process;Prognosis;Protein Secretion;Proteins;Publishing;Recombinants;Relapse;Reporting;Resistance;response;Role;Sampling;Series;Signal Pathway;Signal Transduction Pathway;stem cell function;Testing;Therapeutic;therapeutic target;therapy resistant;Work

PROJECT_TITLE: Crosstalk between leukemic blasts and the BM microenvironment contribute to leukemic transformation

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurodegenerative;Neurosciences

ORG_CITY: MILWAUKEE

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: PROJECT NARRATIVE  Protein aggregation is associated with diseases such as Alzheimer’s disease and ALS, as well as biologically functional biomolecular condensates. Our project focuses on how molecular chaperones manage both types of aggregates. Understanding these important molecular mechanisms will broadening our general understanding of protein aggregation and uncover new avenues for chaperone-based therapies to treat these fatal diseases.

PI_NAMEs: MANOGARAN, ANITA L. (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Age;Alzheimer's Disease;Amyloid;Amyloidosis;Attitude;Binding;Biochemical;Biochemistry;Biological Assay;Biomedical Research;career;Cells;Communication;Complex;Critical Thinking;Data;Disease;Environment;Exposure to;Foundations;Future;Generations;Genetic;Goals;graduate student;Growth;Guanine Nucleotide Exchange Factors;Heat-Shock Proteins 70;Human;improved;innovation;Institution;Liquid substance;Mediating;member;Mentors;Mentorship;Microscopy;Modeling;Modernization;Molecular;Molecular Chaperones;monomer;Nerve Degeneration;Neurodegenerative Disorders;Nucleotides;Pathology;Phase;Physical condensation;Play;Population;Prealbumin;Prions;protein aggregation;Protein Fragment;Protein Structure Initiative;Proteins;Research;Research Personnel;response;Role;skills;Stress;stress granule;Students;success;synergism;System;Systemic disease;Techniques;Technology;Testing;Therapeutic;Training;undergraduate research;undergraduate research experience;undergraduate student;Work;Yeasts

PROJECT_TITLE: Understanding the role of molecular chaperone systems in protein aggregate disassembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-B (81)]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Nanotechnology

ORG_CITY: LOWELL

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

ORG_STATE: MA

PHR: Project Narrative: The proposed research is relevant to public health because there are a number of glutamate rich Intrinsically Disordered Regions (IDR), especially in the proteins that form the contractile machinery of muscle. The focus of the proposed work is to develop an understanding of the chemical and biological nature of nanoparticles with IDPs attached and what environmental signatures lead to changes in those properties. As a result, this work is relevant to the part of NIH’s mission pertaining to developing knowledge of basic biological mechanisms, which will facilitate the development of novel sensors that will have both potential therapeutic and research applications.

PI_NAMEs: ROSS, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: absorption;Acidosis;Amino Acid Sequence;Amino Acids;Antisense Oligonucleotide Therapy;Architecture;Area;Behavior;Binding;Binding Proteins;Biochemical;Biological;biophysical properties;Charge;Chemicals;Clinical;clinically relevant;colloidal nanoparticle;Coupling;Crowding;density;Dependence;design;Development;Disease;DNA;Encapsulated;Environment;environmental change;experimental study;extracellular;Fatigue;Glutamates;Goals;In Vitro;in vivo;innovation;insight;Ionic Strengths;Ischemia;Knowledge;Lead;Length;Ligands;Malignant Neoplasms;mechanical force;Metabolic;Metabolism;Methods;Mission;Modification;Molecular Conformation;Monitor;Muscle;Muscle function;Myocardium;Myomatous neoplasm;nanoGold;nanoparticle;nanoscale;Nanostructures;Nature;novel;Nucleosome Core Particle;Oligonucleotides;optical sensor;Optics;Peptides;physical property;Physiological;Property;Protein Region;Proteins;Public Health;Research;response;sensor;Skeletal Muscle;Solid Neoplasm;Stimulus;Surface;System;Temperature;Testing;theranostics;Therapeutic;United States National Institutes of Health;Vaccines;Work

PROJECT_TITLE: Understanding and Designing pH-Responsive Peptides in Confined Nanoscale Environments

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Neurodegenerative;Neurosciences;Nutrition;Physical Activity;Prevention

ORG_CITY: KENT

ORG_NAME: KENT STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative A loss of energy homeostasis contributes to ageing and neurodegenerative disease. This study will test the effects of physical activity on enhancing energy metabolism which is consistent with the mission of the NIH to promote health. This study is important for public health because it will lead to the development of therapeutic approaches which may prove to be critical for the successful treatment of neurodegenerative disease.

PI_NAMEs: MCDONOUGH, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Aging;Alzheimer's Disease;Automobile Driving;Basal Ganglia;Binding;Binding Sites;Bioenergetics;Brain;brain health;brain metabolism;Brain region;Cell Culture Techniques;Cell Nucleus;Cells;Cerebellum;ChIP-seq;Chromatin;Complex;Cytoplasm;Data;demethylation;Disease;energy balance;Energy Metabolism;Epigenetic Process;Erythrocytes;Exercise;experience;Funding;Gene Chips;Gene Expression;Genes;Genetic Transcription;Genus Hippocampus;Goals;Grant;Health Promotion;Hemoglobin;Hippocampus;histone demethylase;Histone H3;histone methylation;Histones;Homeostasis;Human;Hydrogen Bonding;Immunohistochemistry;Individual;Investigation;KDM5B gene;Lysine;Measures;Mediating;Metabolic;methyl group;Mission;Mitochondria;Molecular;Molecular Conformation;mutant;Mutation;Neurodegenerative Disorders;Neurons;novel;novel therapeutic intervention;Nuclear;overexpression;Oxygen;Parkinson Disease;Physical activity;Production;Public Health;Quantitative Reverse Transcriptase PCR;Rattus;Regulation;Reporting;Research;Research Personnel;Respiration;respiratory;Rodent;Role;Running;Signal Pathway;Signal Transduction;Spirometry;Students;Testing;therapeutic development;Training;undergraduate student;United States National Institutes of Health;volunteer;Western Blotting

PROJECT_TITLE: The hemoglobin beta subunit regulates chromatin and transcription to adapt to metabolic demands

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Infectious Diseases;Nanotechnology;Prevention;Wound Healing and Care

ORG_STATE: MI

PHR: Project Narrative  Nearly a quarter of diabetic patients develop a foot ulcer, which negatively affects the patients’ quality of life and productivity and is a substantial financial burden to the health care system. It is estimated that 12% of these individuals require lower extremity amputation. Current treatment options are costly, demonstrated mixed results and do not actively prevent infection. Current proposal evaluates a novel multifunctional bioadhesive’s ability to simultaneously promote wound healing and prevent infection, though the manipulation of a unique, biomimetic adhesive molecule and redox chemistry.

PI_NAMEs: LEE, BRUCE P (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acceleration;Acids;Adhesions;adhesive protein (mussel);Adhesives;Affect;Amputation;angiogenesis;Animal Model;Anti-Inflammatory Agents;antimicrobial;antioxidant enzyme;Area;Bacteria;Biomimetics;Biopolymers;cancer radiation therapy;Catechols;Cell Culture Techniques;cell motility;Cell Proliferation;Cell Survival;Chemistry;chemotherapy;chronic ulcer;chronic wound;cost;Crosslinker;Cytoprotection;Data;Deposition;Dermal;Development;Devices;Diabetes Mellitus;Diabetic mouse;diabetic patient;diabetic ulcer;Disease;experimental study;Extracellular Matrix;Family suidae;Fibrin;Fibroblasts;Film;Financial Hardship;Foot Ulcer;Formulation;Future;Genetic Transcription;healing;Healthcare Systems;Hospitalization;Hydration status;Hydrogen Peroxide;Impaired wound healing;Impairment;Individual;Infection;Infection prevention;Inflammation Mediators;Inflammatory Response;keratinocyte;Lower Extremity;Macrophage;meter;Modeling;Mussels;nanocomposite;nanoparticle;novel;Outcome;oxidation;Oxidation-Reduction;Patients;Performance;Persons;Phenotype;portability;Powder dose form;Preparation;Productivity;Property;protein expression;Proteins;Pseudomonas aeruginosa;Publications;Quality of life;Recovery;recruit;regenerative;repaired;Silicon Dioxide;Site;skin wound;Steroids;System;Testing;Thick;Ulcer;United States;Vascular Endothelial Cell;Venous;Work;wound;wound healing;Wound Infection;Wound models

PROJECT_TITLE: Mutlifunctional Nanocomposite Bioadhesive for Diabetic Wound Repair

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: GRAND FORKS

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

PHR: The patterns of astrocytic activity and their relationships with behaviors in health and disease conditions remain largely unexplored, due to the lack of high-speed volumetric imaging system. This project will develop a novel platform for astrocyte imaging in freely behaving animals. Our platform will be a valuable tool for the neuroscience community for decoding the roles of astrocytes in disease and behavior.

PI_NAMEs: LIANG, BO  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: absorption;adaptive optics;Address;Adopted;Animals;Astrocytes;awake;Behavior;Benchmarking;Brain;brain cell;brain tissue;Calcium;Cephalic;Chemicals;Communities;computerized data processing;Corpus striatum structure;Coupled;cranium;Data Analyses;Data Set;deep learning;deep learning model;design;Detection;digital;Disease;Dorsal;Engineering;Ensure;experimental study;Fiber;fluorescence microscope;Fluorescence Microscopy;generative adversarial network;Genetic;Goals;graduate student;Head;Health;Hybrids;Image;Image Enhancement;image processing;imaging approach;Imaging Device;imaging system;improved;in vivo;in vivo imaging;instrument;interest;Investigation;Light;light scattering;Lighting;Machine Learning;Measures;Methods;Microscope;Microscopy;miniaturize;Modeling;Molecular;Morphology;Motor;Motor Cortex;Movement;multiphoton microscopy;Mus;Names;Nature;Nervous System Disorder;neural;Neuroanatomy;Neuroglia;Neurons;neuropsychiatric disorder;Neurosciences;novel;optical imaging;Optics;Pattern;Penetration;Performance;Physiological;Research;Research Personnel;Resolution;Rodent;Role;sample fixation;Sampling;Scanning;Science;sensor;Slice;Source;Specimen;Speed;Spinal Cord;success;System;Techniques;Testing;Thinness;Tissue Sample;Tissues;tool;training opportunity;two-photon;undergraduate student;Visible Radiation;Vision;voltage;Work

PROJECT_TITLE: Miniature Selective Plane Illumination Fluorescence Microscope for High-resolution Volumetric Imaging in Freely Behaving Mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-Y (82)]