ORG_CITY: MADISON

ORG_NAME: WM S. MIDDLETON MEMORIAL VETERANS HOSP

ORG_STATE: WI

PHR: RELEVANCE: Glioblastoma (GBM) is a highly malignant brain tumor, with documented increased risk in Gulf war veterans. Exposure to nerve agents in Iraq in 1991 have been linked with a higher risk of developing brain tumors, with distinct patterns of brain changes when compared with other Veterans. Additionally, Veteran GBM patients tend to have higher comorbidity burden and worse overall survival than the general U.S. population. There is currently an unmet clinical need for developing companion diagnostic solutions using routine clinical MRIs that can reliably (a) identify Veteran GBM patients who will or will not respond to conventional chemoradiation, and (b) differentiate benign treatment changes from tumor recurrence. We propose to develop Neuro-image risk classifier (NeuRisC), which when successfully deployed will pave the way for improving quality- of-life in Veteran GBM patients by (a) decreasing financial and therapeutic toxicity associated with chemotherapy, while (b) alleviating anxiety and unnecessary biopsies in patients with benign treatment changes.

PI_NAMEs: TIWARI, PALLAVI  (contact)

PROJECT_TERMS: Adjuvant;Adjuvant Chemotherapy;Adoption;Aftercare;Anatomy;Anxiety;Appearance;Artificial Intelligence;Award;Benign;Biological;Biophysics;Biopsy;Brain;brain magnetic resonance imaging;Brain Neoplasms;brain parenchyma;Cells;Characteristics;chemoradiation;chemotherapy;Clinical;Clinical assessments;Clinical Trials;clinically actionable;cohort;Combination Drug Therapy;Combined Modality Therapy;comorbidity;companion diagnostics;conventional therapy;cost;Coupled;Data;deep learning;Diagnosis;Diagnostic;diagnostic tool;Discrimination;Disease;Disease Progression;Entropy;Excision;Exposure to;financial toxicity;follow-up;Gadolinium;Genomics;Glioblastoma;Glioma;Gulf War veteran;Healthcare Systems;Heterogeneity;high risk;Histologic;Histology;Human;Image;imaging biomarker;improved;innovation;Institution;Intervention;Ionizing radiation;Iraq;Lesion;Link;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Measurement;Medical center;Methylation;MGMT gene;Molecular;Morbidity - disease rate;Morphology;mortality;MRI Scans;nerve agent;Nervous System Disorder;neuroimaging;Neurologic;Ohio;Oncologist;Operative Surgical Procedures;Pathway interactions;Patient Selection;Patients;Pattern;Perfusion;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Play;Population;predictive marker;prognostic;promoter;Quality of life;Radiation;radiation effect;Radiation therapy;radiologist;radiomics;Reader;Reading;Recurrent tumor;Refractory;Resistance;Resort;responders and non-responders;response biomarker;Risk;Role;Scanning;segregation;Shapes;side effect;Site;standard of care;success;Surface;Survival Rate;Tennessee;Texture;Time Management;Tissues;treatment effect;treatment response;Treatment-related toxicity;tumor;Tumor Biology;tumor microenvironment;Unnecessary Surgery;Validation;Vasodilation;Veterans;Visual;War;Work

PROJECT_TITLE: Artificial Intelligence-based decision support for chemotherapy-response assessment in Brain Tumors


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Lung;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: CHARLESTOWN

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

ORG_STATE: MA

PHR: This work will determine if the addition of ventilatory support and/or the drug Buspirone improve ventilatory exercise responses in high level SCI and result in greater improvements in aerobic capacity, pulmonary function, and cardiometabolic risk. The two approaches to overcome ventilatory limitations treat mechanical constraints of paralyzed pulmonary musculature and loss of serotonergic respiratory control, both of which may contribute to blunted ventilatory responses. The ultimate purpose of this research is to optimize exercise for a population that both needs and seeks the broad range of benefits that exercise can confer.

PI_NAMEs: TAYLOR, J ANDREW (contact)

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: Acute;Aerobic;Aerobic Exercise;Aging;Animal Model;arm;Astrocytoma;blood lipid;Brain Stem;Brain Stem Infarctions;Buspirone;cardiometabolic risk;cardioprotection;Cardiopulmonary;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Case Study;Combined Modality Therapy;Couples;Double-Blind Method;Enrollment;Exercise;exercise capacity;exercise intervention;Exercise Tolerance;exercise training;Fatty acid glycerol esters;FPS-FES Oncogene;functional electrical stimulation;Funding;General Population;Heart Diseases;high risk;Human;Hybrids;improved;Individual;Injury;Leg;Lung;Lung Diseases;male;Mechanics;mortality risk;Motor Neurons;Multiple Sclerosis;muscle form;Muscle function;neural;neuromechanism;Neuronal Plasticity;novel strategies;Older Population;Paralysed;Pharmaceutical Preparations;Pharmacological Treatment;Placebos;Population;prevent;pulmonary function;Rattus;Recovery;Research;Respiration Disorders;respiratory;Respiratory physiology;response;Rett Syndrome;Risk Factors;Serotonin Agonists;skeletal;Skeletal Muscle;Spinal;Spinal Cord;Spinal cord injury;Thinness;Training;ventilation;Work

PROJECT_TITLE: HYBRID-FES EXERCISE TO PREVENT CARDIOPULMONARY DECLINES IN ACUTE HIGH LEVEL SCI

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Inappropriate use of antibiotics is linked to antibiotic resistance and life-threatening adverse events. Positive urine tests are a major driver of inappropriate antibiotic use. Asymptomatic surgical patients are often screened before surgery and positive urine tests treated with antibiotics, despite guidance that patients without infection symptoms should not have a urine tests performed and should not receive antibiotics if the test is positive. The overall goal of the proposed study is to develop and pilot-test a de-implementation tool to end a common long- standing practice of screening and treating urine tests in asymptomatic surgical patients. First, we will use VA data to identify factors associated with urine testing and antibiotic treatment in surgical patients and track these in real time. Second, we will visit 5 VA hospitals and interview surgeons and other providers to determine why urine tests and treatment are done and what interventions would be acceptable. Third, we will create a tool to stop unnecessary urine testing and antibiotic treatment and evaluate it in 10 VA hospitals.

PI_NAMEs: GUPTA, KALPANA  (contact);SCHWEIZER, MARIN LEIGH

PROJECT_TERMS: acute care;Address;Adopted;Adverse effects;Adverse event;Advisory Committees;American;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Area;Bacterial Antibiotic Resistance;Bacteriuria;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;clinical practice;Clinical Practice Guideline;Clostridium difficile;Collaborations;Communicable Diseases;community living;Data;Data Analyses;data warehouse;Databases;Deimplementation;evidence base;Evidence based practice;Fright;Future;Goals;Guidelines;Harm Reduction;Healthcare;Healthcare Systems;Homogeneously Staining Region;Hospitals;implementation framework;implementation measures;implementation science;implementation strategy;implementation tool;improved;improved outcome;Infection;Infection prevention;innovation;insight;Intervention;Interview;Knowledge;Letters;Life;Link;Methods;Modeling;Operative Surgical Procedures;Organizational Culture;Outcome;Patients;Perioperative Care;pharmacy benefit;pilot test;Population;Positioning Attribute;Postoperative Period;Prevention;Prevention Research;Process;programs;Provider;provider behavior;Psyche structure;Publications;Random Allocation;Recommendation;Research;Resources;screening;Site;social;Societies;Stimulus;success;Surgeon;Surgical Wound Infection;Symptoms;Testing;theories;Time;Time Series Analysis;time use;tool;Translating;Update;Urinary tract infection;Urine;Variant;Veterans;Visit;Work

PROJECT_TITLE: De-Implementing Testing and Treating of Urine Cultures in Asymptomatic Patients

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Many aspects of the neurosynaptic pathology that mediate the influence of TDP-43 on cognition and behavior are relatively unexplored. Similarly, the influence of microglia activation and immune alterations in this process are unknown. The proposed research will generate a great deal of information on the status of synapses and potential trans-synaptic spread of TDP pathology as well as the role of microglia in these processes and in immune alterations. The findings have the potential to illuminate pathways that can serve as therapeutic targets.

PI_NAMEs: GEULA, CHANGIZ  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Ablation;Alzheimer's Disease;Anatomy;Apoptosis;Area;Autopsy;base;Behavior;Behavior assessment;Behavioral;Biology;Brain;brain tissue;cerebral atrophy;Chemicals;Clinical;clinical phenotype;Cognition;Dementia;Dendritic Spines;density;dentate gyrus;design;Disease;disease phenotype;DNA-Binding Proteins;exosome;Exposure to;Frontotemporal Lobar Degenerations;Gene Expression;Genetic;Gliosis;Goals;gray matter;hippocampal sclerosis;Hippocampus;Human;human disease;Immune;immune activation;Investigation;Mediating;Methods;Microglia;misfolded protein;mouse model;Mus;neurochemistry;Neurodegenerative Disorders;Neurology;Neurons;neuropathology;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Phagocytosis;Play;Process;Production;Productivity;Prosencephalon;protein expression;protein TDP-43;Proteins;Proteome;Research;Research Personnel;Resources;Response Elements;Role;Specificity;Specimen;Surveys;Synapses;synaptic pruning;Testing;therapeutic target;Time;Tissues;Transactivation;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Mice;Transgenic Organisms;white matter

PROJECT_TITLE: Concordance of TDP-43 Inclusions with Cortical Atrophy and Clinical Phenotype


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Narrative Influenza viruses cause severe disease in infants. In contrast, SARS-CoV-2 infection in infants is generally mild and less severe. This is remarkable and offers a unique opportunity to study how the infant immune system responds to these two viral infections.

PI_NAMEs: PASCUAL, MARIA VIRGINIA;RAMILO, OCTAVIO  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 2019-nCoV;Acute;acute infection;Address;Affect;Antibodies;Antibody Response;Antibody titer measurement;Antigens;ATAC-seq;B-Lymphocytes;Blood;Blood Cells;CD8-Positive T-Lymphocytes;Cell Nucleus;Cell surface;Cells;Cellular Assay;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Child;COVID-19 vaccination;COVID-19 vaccine;cytokine;design;Development;Disease;droplet sequencing;Epigenetic Process;epigenome;Epitopes;Evaluation;Evolution;Exposure to;Genes;Genetic Transcription;high risk population;Hospitalization;Immune;Immune response;Immune system;Immunity;Immunophenotyping;imprint;improved;Infant;infant infection;Infection;Influenza;influenza infection;Influenza vaccination;influenzavirus;Learning;Life;Longitudinal cohort;Morbidity - disease rate;mortality;multidimensional data;Multivariate Analysis;Older Population;Participant;Pattern;Pattern recognition receptor;Peripheral Blood Mononuclear Cell;Phenotype;Production;Research Project Grants;respiratory virus;response;SARS-CoV-2 infection;seasonal influenza;Shapes;Specificity;transcriptome;Vaccination;Vaccines;Viral Respiratory Tract Infection;Virus;Virus Diseases

PROJECT_TITLE: Early life respiratory viral infections shape immune development trajectories


NIH_SPENDING_CATS: Infectious Diseases

PI_NAMEs: RAMILO, OCTAVIO  (contact)

PROJECT_TERMS: Administrator;Annual Reports;Budgets;Communication;conflict resolution;Data Analyses;data integration;data management;data sharing;data submission;Development;Ensure;Environment;experience;Goals;Guidelines;Human Resources;Immune;Immune response;Individual;Institution;Leadership;Life;meetings;member;Metadata;Monitor;multidisciplinary;National Institute of Allergy and Infectious Disease;programs;Research Personnel;Research Project Grants;Role;Schedule;Shapes;Supervision;timeline;Travel;United States National Institutes of Health;videoconference;Viral Respiratory Tract Infection;Virginia;Visit;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Data Science;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

PI_NAMEs: ELEMENTO, OLIVIER  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Antibody titer measurement;Bioinformatics;Cells;Clinical;Clinical Data;clinical phenotype;cloud based;cohort;Collaborations;Communities;computational platform;Data;Data Analyses;data dissemination;data ingestion;data integration;data integrity;data management;data modeling;data platform;Data Set;data standards;Data Storage and Retrieval;database of Genotypes and Phenotypes;Databases;Development;diverse data;Doctor of Philosophy;electronic data;Ensure;Genes;Goals;Immune;Infant;Influenza;Informatics;Israel;Laboratories;Life;Linear Models;longitudinal dataset;Machine Learning;machine learning model;Measurement;Medicine;Metadata;Multiomic Data;multiple omics;National Institute of Allergy and Infectious Disease;Participant;Pathway Analysis;Pediatric Hospitals;precision medicine;Principal Investigator;Quality Control;Recommendation;Recording of previous events;Research;Research Personnel;Resources;responders and non-responders;Sampling;Serology;Shapes;single cell ATAC-seq;Site;Statistical Data Interpretation;synergism;Techniques;transcriptome sequencing;Vaccines;Viral;Viral Respiratory Tract Infection

PROJECT_TITLE: Data Management and Analysis Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pediatric;Pneumonia and Influenza;Vaccine Related

PI_NAMEs: MEJIAS, ASUNCION  (contact)

PROJECT_TERMS: 2019-nCoV;Age;Biological Assay;Blood;Child;Clinical;Clinical Data;Clinical Distribution;COVID-19;COVID-19 vaccination;Data Analyses;Data Collection;data curation;data exchange;data integration;data management;Development;Doctor of Medicine;Enrollment;follow-up;Goals;Human;Immune;Immunology procedure;improved;Infant;Infection;Influenza;influenza infection;Influenza vaccination;influenzavirus;Life;Longitudinal cohort;Measurement;Measures;nasopharyngeal swab;Nasopharynx;participant enrollment;Patients;Performance;Principal Investigator;programs;Resources;respiratory;Sampling;SARS-CoV-2 infection;Shapes;synergism;Time;Viral;Viral Load result;Viral Respiratory Tract Infection

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Lung;Pediatric;Pneumonia and Influenza;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Acute;acute infection;Address;Adult;Affect;Antibodies;Antibody Response;Antigens;B-Lymphocytes;betacoronavirus;Biological Assay;Blood;Blood Platelets;Cell surface;Cellular Assay;Child;Clinical;cohort;Coronavirus;COVID-19;COVID-19 vaccination;COVID-19 vaccine;cross reactivity;design;Development;droplet sequencing;Enrollment;Epitopes;Evaluation;Evolution;Genes;Genetic Transcription;high risk population;Hospitalization;Immune;Immune response;Immune system;Immunity;imprint;improved;Infant;infant infection;Infection;Inflammation;Influenza;influenza infection;Influenza vaccination;influenzavirus;Interferons;Life;Longitudinal cohort;monocyte;Morbidity - disease rate;mortality;Multivariate Analysis;neutrophil;Older Population;overexpression;Pattern;Phenotype;Primary Infection;Proteins;Recombinant Proteins;Recombinants;respiratory virus;response;Sampling;SARS-CoV-2 infection;SARS-CoV-2 variant;seasonal coronavirus;Shapes;Site;Specificity;transcriptome;Vaccination;Variant;Viral Respiratory Tract Infection;Virus;Virus Diseases;Whole Blood

PROJECT_TITLE: Project 1


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Influenza;Lung;Pediatric;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: PASCUAL, MARIA VIRGINIA (contact)

PROJECT_TERMS: 2019-nCoV;Adult;Affect;age group;age related changes;analysis pipeline;Antibody Response;Antibody titer measurement;ATAC-seq;B-Lymphocytes;Bacterial Infections;Biological Assay;Blood;Blood Cells;CD8-Positive T-Lymphocytes;Cell Count;Cell Nucleus;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Child;Childhood;Chromatin;commensal microbes;COVID-19 vaccine;Custom;cytokine;Data;Data Set;Development;Disease;Enrollment;Epigenetic Process;epigenome;experience;Exposure to;flexibility;Gene Expression Profile;Genetic Transcription;genome-wide;Health;high risk;Human;human old age (65+);Immune;immune function;Immune response;Immune system;Immunity;Immunologic Monitoring;Immunophenotyping;imprint;Infant;Infection;Influenza;influenza infection;Influenza vaccination;innovative technologies;Knowledge;Learning;Life;life span;Longitudinal Studies;Molecular;Monitor;multidimensional data;Outcome;Participant;pathogenic microbe;Pathway interactions;Pattern recognition receptor;Peripheral Blood Mononuclear Cell;Phenotype;Population;postnatal;Production;Property;respiratory virus;response;Risk;Sample Size;Sampling;SARS-CoV-2 infection;seasonal influenza;severe COVID-19;Shapes;Systems Biology;Technology;tool;transcriptome;transcriptome sequencing;trend;Vaccination;Vaccines;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases

PROJECT_TITLE: Project 2


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering;Genetics;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: AMHERST

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE We propose a highly innovative research plan to ameliorate the effects of aging and enhance the therapeutic potential of senescent cells and the regenerative capacity of aged skeletal muscle tissue. The proposed research is important and timely, given the surge in the aging population in the US and the world and the severe effects of aging on skeletal muscle and related frailty affecting the elderly. Successful attainment of this work will have significant impact in understanding cellular senescence as well as the development of treatments to restore tissue/organ function and ameliorate the negative effects of aging.

PI_NAMEs: ANDREADIS, STELIOS THEOHARIS (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: 3-Dimensional;Adult;Affect;age acceleration;age effect;age related;aged;Aging;aging population;aging related disease;aging reversal;Animal Model;Animals;anti aging;Arteries;Biochemical Pathway;Biological Assay;Biomedical Engineering;cell age;Cell Aging;cell injury;Cell model;Cell Physiology;Cell Reprogramming;Cell Therapy;Cells;Collagen Type III;Data;design;Development;disability;DNA Damage;druggable target;Elastin;Elderly;Embryo;Engineering;extracellular;Extracellular Matrix;follow-up;frailty;functional restoration;Generations;Genes;Goals;high risk;Impairment;improved;In Vitro;in vivo;inducible gene expression;innovation;Laboratories;Measures;mechanical properties;Mediating;Medical;Mesenchymal Stem Cells;Metabolic;Metabolism;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Muscle;muscle aging;Muscle Fibers;muscle form;Muscle function;muscle regeneration;Myoblasts;Natural regeneration;new therapeutic target;novel;older patient;Organ;Patients;Phenotype;Physiology;pluripotency;Premature aging syndrome;Progeria;programs;Quality of life;regeneration potential;regenerative;Regenerative capacity;Regenerative Medicine;Rejuvenation;Reporting;Research;Resources;response to injury;Risk;sarcopenia;senescence;senescent cell;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle metabolism;Skeletal Myoblasts;Skin;small molecule;Smooth Muscle Myocytes;stem cells;success;System;Therapeutic;therapy development;Tissue Engineering;Tissues;tool;transcription factor;transcriptome;transcriptome sequencing;Work

PROJECT_TITLE: Restoring the regenerative capacity of the aged muscle

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Chicago

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative This project examines the persistence, fate and function of hippocampal neurogenesis in the aging and Alzheimer’s brains.

PI_NAMEs: LAZAROV, ORLY  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Adult;Age;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease related dementia;Apoptosis;Astrocytes;Autopsy;Brain;Cell Cycle;Cells;Cognition;cognitive function;cognitive performance;cognitive reserve;cohort;dentate gyrus;Episodic memory;Exhibits;experimental study;Goals;Hippocampus;Human;human disease;Impaired cognition;Impairment;Individual;insight;Knowledge;Learning;Life;Memory;Memory Loss;mild cognitive impairment;Molecular;Nature;nerve stem cell;neural;neuroblast;neurogenesis;Neurons;novel;Nuclear Antigens;Participant;Pathologic;Patients;Performance;Persons;presynaptic;progenitor;Proliferating;Proliferating Cell Nuclear Antigen;Proxy;receptor;resilience;RNA;Rodent;Role;Signal Transduction;SNAP receptor;stem;stem cells;super ager;Technology;Testing;Therapeutic;tool;Transcript;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Hippocampal neurogenesis in cognitive function and dysfunction in Alzheimer's disease.


ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: The long-term goal of the proposed research is to ensure that Veterans receive high-value care, regardless of whether this care is provided by VA medical centers (VAMCs) or in the community in non-VA settings. This study will advance VA’s understanding of which types of low-value health services (i.e., services whose costs or harms exceed their benefits) are most frequently provided to Veterans, which are most costly, and reasons for their use, in three care settings: within the VA in VAMCs, in non-VA healthcare settings accessed through VA Community Care, and in non-VA healthcare settings accessed through Medicare benefits. It will provide VA with critical information needed to prioritize and develop performance measures, policies, and interventions to ensure that Veterans avoid low-value care in VA and non-VA settings, as VA evolves as a provider and payer of Veteran care. It will also allow Veterans to consider the value of care when choosing to receive healthcare in VA versus non-VA settings.

PI_NAMEs: THORPE, CAROLYN TIMBERLAKE (contact)

PROJECT_TERMS: Address;Age;Area;beneficiary;Cardiovascular system;Caring;Categories;Classification;cohort;Communities;Community Healthcare;cost;cost estimate;Data;Deimplementation;Diagnostic;Dimensions;Dual Enrollment;Eligibility Determination;empowerment;Enrollment;Ensure;Evolution;Frequencies;Goals;Health Care Costs;health care settings;health economics;Health Insurance;Health Personnel;health service use;Health Services;Health system;Healthcare;Healthcare Systems;high risk;human old age (65+);Image;implementation efforts;improved;innovation;Intervention;Interview;Knowledge;life span;Light;Measures;Medical center;Medicare;Medicare claim;Methodology;Methods;multidisciplinary;multilevel analysis;novel;operation;Operative Surgical Procedures;Parents;Patients;Pattern;Performance;Policies;Population;Prevalence;Preventive;Privatization;Procedures;programs;Provider;Quality of Care;Reporting;Research;Risk;Safety;Screening for cancer;Services;Statutes and Laws;Structure;Subgroup;Testing;United States;Variant;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Use and costs of low-value health services by Veterans in VA and non-VA settings


NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Huntington’s disease (HD), with its single genetic cause, an expanded CAG repear in HTT, is an inherited neurodegenerative disorder that devastates entire families. This project uses genetic and genomic approaches to uncover other genes that significantly influence when diagnosable symptoms emerge and how rapidly they worsen. Using a combination of human HD disease subject sample collections, induced pluripotent stem cell lines and neuronal cells derived from them, we will home in on the precise genes and biological pathways that influence the distinct HTT CAG-initiated disease processes that lead to onset and worsening of disease, respectively. We will thereby generate the knowledge and experimental resources to support therapeutic development for the first time based upon targets already validated to alter the rate of HD in humans.

PI_NAMEs: GUSELLA, JAMES F (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Affect;Age;Alleles;Biological;Biological Models;Biological Process;CAG repeat;Cell Line;Cells;Cessation of life;Characteristics;Chorea;Clinical;clinical diagnosis;Clinical Trials;Code;Codon Nucleotides;Cognitive;Collaborations;cost;CRISPR/Cas technology;Data;Diagnosis;Disease;disease phenotype;Disease Progression;DNA Maintenance Process;effective therapy;Family;Foundations;Gene Expression;Genes;Genetic;genetic approach;Genetic Transcription;Genetic Variation;genome-wide;Genomic approach;Glutamine;Grant;Haplotypes;Home;Human;human data;Human Genetics;human model;Huntington Disease;Huntington gene;Individual;induced pluripotent stem cell;Inherited;Intervention;Knowledge;Laboratories;Length;Mediating;Modification;Motor;mouse model;Mutation;Nature;Neurodegenerative Disorders;Neurons;new therapeutic target;novel;Onset of illness;Participant;Pathogenesis;Pathway interactions;Patients;Pharmacologic Substance;Phenotype;polyglutamine;premature;prevent;Process;Property;Proteins;Regulation;Reporting;Resources;RNA;Route;sample collection;Signal Transduction;Societies;success;Symptoms;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Time;time interval;Toxic effect;Variant

PROJECT_TITLE: Disease-Modifying Genes in Huntington's Disease

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: FD

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Project Narrative This application to the FDA CVM VET-LIRN infrastructure program will allow for enhancement of diagnostic testing capacity and quality, in addition to the potential for new method development that enables the rapid detection and identification of contamination or adulteration that could affect human and animal health through the food and drug products.

PI_NAMEs: LOY, JOHN DUSTIN (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: Increasing Vet-LIRN Testing Capacity at the Nebraska Veterinary Diagnostic Center


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Cognitive aging is the decline in performance with age seen in otherwise healthy people free of even of asymptomatic degenerative brain disease. The anterior cingulate cortex (ACC) appears to be the principal site of hypometabolism in cognitive aging; this decline correlates with declining executive function. A hypothesis posits ACC dysfunction is related to oxidative stress that is seen universally in models of aging. Furthermore, emotional stress can contribute to oxidation thereby aggravating ACC hypometabolism. This project tests whether aging and emotional stress, the latter as indexed by PTSD, is associated with redox stress in the ACC. If demonstrated and quantified, use of antioxidants such as nicotinamide riboside or N-acetyl cysteine will be motivated to treat and prevent this aging-related cognitive decline.

PI_NAMEs: PARDO, JOSE V (contact)

PROJECT_TERMS: Accounting;Adenine;Adult;Aerobic Exercise;aerobic glycolysis;Age;age acceleration;age related decline;Age-associated memory impairment;Aging;aging brain;aging related;Alzheimer's Disease;American;Amyloid;Anterior;antioxidant therapy;Antioxidants;Apoptosis;Area;Atrophic;Attention;baby boomer;Behavior Disorders;Biochemical Pathway;Biological Markers;Biology;Brain;Brain Diseases;Buffers;Cell Aging;Cell Respiration;Chronic;Chronic Post Traumatic Stress Disorder;cingulate cortex;Clinical;Clinical Trials;cofactor;Cognition;Cognition Disorders;Cognitive;Cognitive aging;cognitive change;Cognitive deficits;cognitive reserve;combat;Cysteine;Data;Deposition;Development;Diet;Dinucleoside Phosphates;Discipline;Disease;DNA Damage;DNA Methylation;DNA Repair;Drug Metabolic Detoxication;Economics;Elderly;Emotional Stress;endophenotype;Environment;epigenetic marker;executive function;Exposure to;Functional disorder;Future;Generations;Gluconeogenesis;glucose metabolism;Glutathione;Health;Health behavior;Human;human old age (65+);Impaired cognition;Impairment;in vivo;indexing;Inflammation;Infrastructure;interest;Intervention;ketogenesis;Laboratories;lipid biosynthesis;Lipids;Magnetic Resonance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;medial temporal lobe;Mediating;Medical;Memory;Memory impairment;Mental disorders;Metabolic;Metabolic dysfunction;Metabolism;Methods;mitochondrial dysfunction;Modeling;NADH;NADP;Nerve Degeneration;Neurodegenerative Disorders;neuronal excitability;Neuropsychological Tests;nicotinamide-beta-riboside;Nicotine;nicotine use;novel;novel diagnostics;Occipital lobe;Outcome;Oxidants;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Stress;Pathologic;pathological aging;Pathway interactions;Patients;Pellagra;Performance;Persons;Pharmacologic Substance;Plasma;Play;Post-Traumatic Stress Disorders;pre-clinical;prevent;Prevention;Prevention strategy;Proteins;Psyche structure;Quality of life;Reactive Oxygen Species;Regulation;rehabilitation strategy;Research;Research Priority;response;Risk Factors;Role;Secondary Prevention;Severities;Signal Transduction;Sirtuins;Site;Stress;stress disorder;stress management;Symptoms;System;tau Proteins;Telomere Shortening;Testing;Therapeutic;therapeutic target;Trauma;Universities;verbal;Veterans;Visit;Work;young adult

PROJECT_TITLE: Aging, PTSD, and the Anterior Cingulate Cortex (ACC)


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Rare Diseases

PHR: PUBLIC HEALTH RELEVANCE This proposal is relevant to public health because it will generate new, comprehensive data on the cornea and develop a novel instrument, which may advance the diagnosis and treatment of keratoconus, the safety and visual outcome of refractive surgeries, and the accuracy of intraocular pressure measurement. Therefore, the proposed research is relevant to the NIH’s mission of fostering innovative research strategies to bolster the nation’s ability to treat disease.

PI_NAMEs: YUN, SEOK-HYUN ANDY (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Air;Algorithms;Beds;biomechanical test;Biomechanics;Cadaver;Caring;Chronic;Clinic;Clinical;Clinical Data;Collagen Fiber;Cornea;Corneal Diseases;Corneal Stroma;crosslink;Data;Degenerative Disorder;Development;Devices;Diagnosis;diagnostic biomarker;Disease;Elasticity;elastography;Equilibrium;Error Sources;Eye;Eye Banks;Family suidae;Fibrillar Collagen;first-in-human;Fostering;Frequencies;Glaucoma;Goals;high intraocular pressure;Homeostasis;Human;human data;human study;human subject;Hypertension;improved;in vivo;indexing;innovation;insight;instrument;interest;Intervention;Keratoconus;Laser In Situ Keratomileusis;lens;life span;Machine Learning;Maps;Measurement;Measures;mechanical properties;Mechanics;Mission;Modification;Modulus;Natural regeneration;novel;Ocular Hypertension;Operative Surgical Procedures;Optics;Outcome;Pathologic;Pathological Dilatation;Patients;Physiologic Intraocular Pressure;Play;Procedures;Process;Property;Public Health;public health relevance;Reading;Research;Resolution;response;Role;Safety;Sclera;screening;Shapes;Stress;Structure;System;Techniques;Technology;Tissues;tonometry;tool;United States National Institutes of Health;Vision;Visual

PROJECT_TITLE: In vivo high-resolution mapping of the elastic moduli and tensile stress in the human cornea

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Uterine Cancer;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: INTEGRAL MOLECULAR

PHR: PROJECT NARRATIVE This proposal will contribute to public health and the treatment of human disease by resulting in a therapeutic against CLDN6 for the treatment of late-stage solid tumors. Solid tumors kill 580,000 Americans annually, and there is an unmet need for safe and effective treatments for patients with late-stage ovarian, endometrial, testicular, gastric, and pancreatic cancers.

PI_NAMEs: RUCKER, JOSEPH BENJAMIN (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: Abbreviations;Address;Adverse effects;Affinity;American;Amino Acids;Antibodies;Binding;Biological Assay;biopharmaceutical industry;Biopsy;Biosensor;cancer cell;Cancer cell line;cancer type;candidate selection;CD3 Antigens;CD34 gene;cell killing;Cell model;Cessation of life;claudin 6;Clinic;Clinical;clinical development;clinical efficacy;cytokine;cytokine release syndrome;Data;Development;differential expression;Drug Kinetics;effective therapy;efficacy testing;Endometrial Carcinoma;Engineering;Exhibits;experimental study;extracellular;Failure;Family member;Funding;Future;Human;human disease;humanized mouse;In Vitro;in vivo;Integral Membrane Protein;Isoelectric Point;Lead;light scattering;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of testis;malignant stomach neoplasm;manufacture;Mass Spectrum Analysis;Mediating;melting;Membrane;Membrane Proteins;Modeling;Monoclonal Antibodies;Mus;neoplastic cell;ovarian neoplasm;overexpression;Patients;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;pre-clinical;Proteins;Proteome;Public Health;Risk;Risk Assessment;Safety;Small Business Innovation Research Grant;Solid Neoplasm;Specificity;stem cells;T cell infiltration;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Temperature;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;therapeutic target;therapeutically effective;Tight Junctions;Time;timeline;Tissues;Toxic effect;tumor;Tumor Volume;Viscosity;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Development of Claudin MAbs for Treating Solid Tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-S(12)B]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Neurosciences;Prevention;Stroke

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The risk of treatment of brain aneurysms can exceed their rupture risk (which has devastating consequences) thus creating an urgent need to discriminate between fragile and robust aneurysms in order to make precise and personalized decisions about their clinical management. With the long-term goal of creating practical means of assessing aneurysm wall vulnerability and rupture risk, and having found that aneurysms with blebs (secondary outpouchings) can have different wall structures and failure mechanisms than other aneurysms, the objective of this project is to identify clinically measurable features that predispose some aneurysms to bleb formation and then determine which wall characteristics determine wall vulnerability in these aneurysms. The knowledge and results generated in this project are expected to have a positive impact on human health because they will improve risk assessment in cerebral aneurysms, provide targets for drug therapy and identify preventative approaches for aneurysm treatment.

PI_NAMEs: CEBRAL, JUAN R;ROBERTSON, ANNE MARIE (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Adult;Affect;Aneurysm;Area;Arteries;bioimaging;Biology;Biomechanics;Blood flow;Blood Pressure;Brain;Brain Aneurysms;brain surgery;Bulla;Cerebral Aneurysm;Characteristics;Clinical;Clinical Management;clinical practice;clinical risk;Clinical Treatment;Clip;Collagen Fiber;Computer Models;Consensus;Data;Daughter;Dental;dental infection;design;disability;Evaluation;Failure;Future;Geometry;Goals;Growth;Health;hormone therapy;Human;implantation;improved;in silico;innovation;Intracranial Aneurysm;Investigation;Knowledge;Life;Lifelong disability;Link;Liquid substance;Measurable;mechanical load;Mechanical Stress;Mechanics;Methodology;Methods;Modeling;modifiable risk;mortality;mortality risk;multidisciplinary;Neck;Neurosurgeon;novel strategies;pathogen;Pathologic;Patients;Periodontal Diseases;personalized decision;Population;Prevalence;prevent;Preventive treatment;programs;Protocols documentation;Research;Research Project Grants;Resected;Risk;Risk Assessment;Risk Factors;risk selection;Rupture;Ruptured Aneurysm;Shapes;Shoulder;soft tissue;Solid;sound;Stents;Stress;Structure;Subcategory;Subgroup;Survivors;targeted treatment;Testing;Thrombosis;Tissues;tool;treatment risk;unnecessary treatment;Work

PROJECT_TITLE: Improving Cerebral Aneurysm Risk Assessment through Understanding Wall Vulnerability and Failure Modes

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative  Resting fMRI is widely used, but there have been no robust biomarkers that have emerged for early prediction of Alzheimer’s disease. The emergence of methods that can capture time-resolved connectivity show greater individualized prediction accuracy than measures that rely on averaging brain connectivity over a relatively long time period. In this work, we will develop time-resolved methods that can capture multiscale dynamic connectivity as well as homogeneous subgroups of subjects and data and utilize these to predict future cognitive decline as well as tau and amyloid measures in a large existing dataset of adults including many with prodromal Alzheimer’s disease. 36

PI_NAMEs: ADALI, TULAY ;CALHOUN, VINCE D (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Address;Adult;Age;Aging;Algorithms;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Baltimore;Biological Markers;biomarker development;blind;Brain;Brain Diseases;Classification;Communities;Complex;Coupling;Data;Data Discovery;Data Set;Dementia;Detection;Development;Disease;Disease Progression;Documentation;Early Diagnosis;Early Intervention;Ensure;Evaluation;Exhibits;Family;flexibility;Frequencies;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;Goals;Growth;Heterogeneity;Impaired cognition;improved;Individual;innovation;interest;Intuition;Joints;large datasets;Longitudinal Studies;Measures;Methods;model building;Modeling;Nature;Neurobehavioral Manifestations;novel;novel marker;Onset of illness;open source;open source tool;Pattern;personalized predictions;Phase;Positron-Emission Tomography;pre-clinical;prodromal Alzheimer's disease;Prognosis;Pythons;repository;Research Personnel;Rest;Sampling;Scanning;simulation;Sleep;Source;spatiotemporal;Specificity;Structure;Study models;Subgroup;tau Proteins;Testing;Time;tool;Universities;user-friendly;Validation;Visualization;web portal;Work

PROJECT_TITLE: Data driven dynamic activity/connectivity methods for early detection of Alzheimer’s


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Preventing acute pain from becoming chronic is a promising therapeutic target. Astrocyte activation is an important component of the chronic pain state. This application proposes to use a combination of molecular, imaging, and behavioral approaches to investigate how astrocyte activation is modulated by microglia and the role of microglia-mediated astrocyte activation in chronic pain. The results from the experiments proposed in this study will elucidate the role of microglia in astrocyte activation and determine if microglia-derived differences in astrocyte state contribute to pain behaviors, providing new therapeutic targets.

PI_NAMEs: NIPPERT, AMY  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Acute;Acute Pain;Affect;allodynia;Animals;Astrocytes;Award;Behavior;behavior test;Behavioral;Biological;Blood - brain barrier anatomy;Calcium;Calcium Signaling;career;Cell Communication;cell type;Cells;Chronic;chronic pain;Chronic Phase;Complex;Complex Regional Pain Syndromes;Correlative Study;critical period;Data;designer receptors exclusively activated by designer drugs;Distress;experimental study;Foundations;Future;Gene Expression;Gene Expression Profiling;glial activation;Glial Fibrillary Acidic Protein;Goals;healing;Health;Homeostasis;Image;Immune;Immunohistochemistry;improved;In Vitro;in vivo;inhibitor;Injury;innovation;Knowledge;Ligands;Measures;mechanical allodynia;Mediating;Mediator;Methods;Microglia;Modeling;Molecular;mouse model;Mus;neuronal excitability;neuroprotection;neurotoxic;Neurotransmitters;new therapeutic target;novel;Pain;pain behavior;pain chronification;pain model;pain signal;Pathway interactions;Peripheral;Phenotype;Preparation;prevent;Proxy;Public Health;Quality of life;receptor;Regulation;Research;Research Proposals;response to injury;Role;Signal Transduction;single nucleus RNA-sequencing;Slice;Spinal Cord;Synaptic Transmission;targeted treatment;Technology;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Thermal Hyperalgesias;Time;Tissues;tool;Training;Translating

PROJECT_TITLE: Microglia-Mediated Astrocyte Activation in the Acute-to-Chronic Pain Transition

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Cancer;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  Effective treatment strategies to halt ovarian cancer peritoneal metastases are still lacking, which is problematic as few ovarian cancer cases are diagnosed prior to this stage. In this proposal, we aim to understand how the omentum, the earliest site of peritoneal metastasis, supports ovarian tumor seeding and dissemination. Ultimately, the insight gained will allow us to uncover more specific therapeutic strategies to improve outcomes for ovarian cancer patients with peritoneal metastasis.

PI_NAMEs: MINTZ, RACHEL  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Adipocytes;Adipose tissue;Advisory Committees;Affect;Architecture;B-Lymphocytes;Back;Binding;bioluminescence imaging;Blood Vessels;cancer cell;Cancer Model;Cancer Patient;cancer seeding;Cardiovascular system;career;Cells;Data;design;Diagnosis;Distal;effective therapy;Enzymes;Fatty acid glycerol esters;Fatty Acids;Flow Cytometry;Fluorescence;fluorescence imaging;Fostering;Greater curvature of stomach;Greater sac of peritoneum;Growth;Hematogenous;Image;Immune;Impairment;implantation;improved;improved outcome;insight;intraperitoneal;Label;Lipodystrophy;Location;Lymphoid;Macrophage;Maintenance;Malignant neoplasm of ovary;Mentorship;Metabolic;Metabolic syndrome;Microscopy;Monitor;mouse model;Mus;Neoplasm Metastasis;novel therapeutic intervention;Observational Study;Omentum;Oncologist;ovarian neoplasm;Pathway interactions;Patient Care;Patients;Peritoneal;Peritoneum;Phenotype;Physicians;Population;Primary Neoplasm;Proliferating;Role;Route;Scientist;single-cell RNA sequencing;Site;spheroids;Spottings;Stains;standard of care;Stromal Cells;subcutaneous;Supporting Cell;T-Lymphocyte;Testing;Therapeutic;Time;Training;Transplantation;Travel;treatment strategy;tumor;Tumor Burden;Tumor Expansion;tumor growth;tumor progression;Tumor Promotion;Vascularization

PROJECT_TITLE: Mechanisms Underlying the Omental Support of Ovarian Cancer Peritoneal Metastasis


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Genetics and genomics are among the most important fields in basic biomedical research, contributing to essentially all medical applications. The Curriculum in Genetics and Molecular Biology is a highly-ranked doctoral program that trains students broadly in these fields. This proposal seeks NIGMS support for training these students for research and research-related careers in academic, industry, government, and non-profit settings. .

PI_NAMEs: SEKELSKY, JEFF J. (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Genetic;National Research Service Awards

PROJECT_TITLE: NRSA in Genetics

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Hypertension;Prevention

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: High blood pressure is the most prevalent modifiable risk factor for dementia and cardiovascular disease among older adults in the United States; however, clinic-based blood pressure measurement is inaccessible to many older adults, especially in the COVID-19 era, often delaying hypertension diagnosis and treatment. While home- based blood pressure measures show promise for overcoming access barriers and promoting more timely treatment, there is a dearth of evidence informing the clinical interpretation of these measurements inolder adults in the United States, a population characterized by high blood pressure variability and discordance from clinic- based blood pressure. Our proposal will perform home blood pressure monitoring and 24-hour ambulatory blood pressure monitoring assessments in over 2,100 community-dwelling adults, aged 80-100 years, establishing the measurement performance, prognostic utility (for dementia and cardiovascular disease), and clinical interpretation of home-based blood pressure measurements in this vulnerable population in the United States.

PI_NAMEs: JURASCHEK, STEPHEN P (contact)

PROGRAM_OFFICER_NAME: REIS, JARED P

PROJECT_TERMS: Address;Adoption;Adult;Affect;Age;Age Years;aged;Aged, 80 and over;aggressive therapy;aging population;Ambulatory Blood Pressure Monitoring;American;Atherosclerosis Risk in Communities;Biosensor;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure intervention;Blood Pressure Monitors;blood pressure variability;Cardiovascular Diseases;Caring;Cessation of life;Clinic;Clinic Visits;Clinical;clinical practice;cohort;Cohort Studies;Collection;Communities;Coronavirus Infections;COVID-19;COVID-19 pandemic;current pandemic;Data;Dementia;dementia risk;design;Devices;Diagnosis;digital monitoring;Elderly;Event;Foundations;Frequencies;Funding;Goals;Health;Home;Home Blood Pressure Monitoring;Hour;human old age (65+);Hypertension;Impaired cognition;Improve Access;improved;innovative technologies;Intervention Trial;Investments;Joints;Knowledge;Machine Learning;Measurement;Measures;Modeling;modifiable risk;Morbidity - disease rate;National Heart, Lung, and Blood Institute;Neurocognitive;older adult;Outcome;outcome prediction;Participant;Performance;Population;Population Heterogeneity;Practice Guidelines;Predisposition;prevent;prognostic;prognostic performance;prognostic value;Prospective Studies;Protocols documentation;racial diversity;Research;Research Personnel;Risk;Risk Factors;risk prediction;risk prediction model;Role;screening;tool;Translations;Transportation;transportation access;trend;United States;virtual;Visit;Vulnerable Populations

PROJECT_TITLE: Prognostic Implications of Home-Based Blood Pressure Monitoring in Older Adults

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ORG_CITY: LOUISVILLE

ORG_NAME: LOUISVILLE VA MEDICAL MEDICAL CENTER

ORG_STATE: KY

PHR: Alcohol abuse exacts a major toll on health and health costs in Veterans. Even though there has been an “epidemic” of hepatitis C in the U.S. and the Veterans Administration, alcohol-related liver injury remains a higher cause of mortality. Studies from the Veterans Administration showed that patients with cirrhosis and superimposed alcoholic hepatitis had > 60% mortality over a four-year period of time, with most of those deaths occurring in the first few months. Thus, the prognosis for this stage of ALD is worse than many common types of cancer, such as breast, prostate and colon. Unfortunately, there is no FDA-approved therapy for any stage of ALD, and this makes the need for this proposed research even more compelling. The proposed studies will help to better understand the molecular mechanisms of alcohol-induced liver and intestinal injury, including alcohol-diet interactions, which may lead to identification of new therapeutic targets and potential dietary interventions for treating ALD, as well as help to explain why only some heavy drinkers develop clinically important ALD.

PI_NAMEs: MCCLAIN, CRAIG J. (contact)

PROJECT_TERMS: Alcohol abuse;Alcohol consumption;Alcoholic beverage heavy drinker;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Animal Model;Arachidonate 15-Lipoxygenase;Attenuated;attenuation;Biological Response Modifiers;Breast;cancer type;Cessation of life;Chronic;Cirrhosis;Clinical;Colon;COVID-19 pandemic;cyclooxygenase 1;cytokine;Cytokine Signaling;Data;Diet;Dietary Fats;Dietary Intervention;Disease;Disease Progression;Down-Regulation;Epidemic;Ethanol;Experimental Animal Model;FAT gene;FDA approved;FPR2 gene;Future;GPR32 gene;gut inflammation;gut microbiota;gut-liver axis;Health;Health Care Costs;Hepatic;Hepatitis;Hepatitis C;Hepatocellular Damage;Homeostasis;Host Defense;Human;Immune;Immune response;Immunity;Impairment;improved;In Vitro;in vivo evaluation;Individual;Inflammation;Inflammatory;intestinal barrier;intestinal injury;Intestinal permeability;Intestines;Linoleic Acids;lipid mediator;Liver diseases;liver inflammation;liver injury;Macrophage;Mediating;Mediator;military veteran;Modeling;Molecular;monocyte;mortality;Mus;new therapeutic target;novel;novel therapeutics;Nuclear;Nutritional;Organoids;Pathogenesis;Pathway interactions;Patients;Phagocytosis;Phenotype;Plasma;Play;Polyunsaturated Fatty Acids;preclinical study;Production;Prognosis;Prostate;PTGS2 gene;receptor;repaired;Research;Resolution;Rodent;Role;Sampling;Severities;Severity of illness;Signal Transduction;Survivors;System;systemic inflammatory response;Testing;Therapeutic Agents;Time;tissue repair;Tissues;Transcript;Transgenic Organisms;Translating;United States Department of Veterans Affairs;Untranslated RNA;Veterans;Whole Blood

PROJECT_TITLE: Inflammation Resolving Lipid Mediators: Novel Therapy for Alcohol AssociatedLiver Disease


ORG_CITY: NASHVILLE

ORG_NAME: TN STATE DEPARTMENT OF AGRICULTURE

PHR: Project Narrative This Cooperative Agreement Program (between TDA and FDA’s Vet-LIRN) will strengthen the overall food/feed safety system. This is accomplished by developing increased capacity and capabilities to detect foodborne pathogens and chemical contaminants which could affect livestock or companion animals.

PI_NAMEs: TRAVIS, ADAM RYAN (contact)

PROJECT_TITLE: Support for TDA Kord Animal Health Diagnostic Laboratory's participation in the FDA's Veterinary Laboratory Investigation and Response Network


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD)

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: PROJECT NARRATIVE This 20th anniversary GRC will be focused on “Identifying the next 20 years of need in In Vivo MR,” with the goal of presenting new state of the art developments while brainstorming the future of hardware and software that would be needed to support evolving medical needs and novel new applications in magnetic resonance methods. The companion GRS will have a related focus that will specifically include trainee speakers and moderators, providing trainees (most of whom will attend the GRC as well) with opportunities for presentation of their work to peers and thought leaders, discussion of emerging areas of MR, and focused networking and mentorship.

PI_NAMEs: DUNN, JEFFREY FRANK (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Academy;Address;Anniversary;Applications Grants;Area;Artificial Intelligence;Awareness;base;California;career;career development;Caring;Clinical;clinical diagnostics;cloud based;commune;Companions;comparative;computer science;Computer software;Computers;Dedications;design;Development;Discipline;Doctor of Philosophy;Educational workshop;Ensure;Evaluation;Evolution;experience;Fertilization;Fostering;Funding;Future;Goals;graduate student;Healthcare;Image;improved;in vivo;innovation;insight;interest;International;Knowledge;Learning;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Medical;Medical Imaging;Medicine;meetings;Mentorship;Methods;Michigan;Minority;Modality;multidisciplinary;Multimodal Imaging;novel;Palpable;peer;Physics;Physiological;Population;Postdoctoral Fellow;posters;Process;programs;Recording of previous events;Recreation;Research;Resolution;San Francisco;Science;Scientist;Societies;Specificity;symposium;System;Technology;technology development;Testing;Time;tool;United States National Institutes of Health;Universities;Visualization;Work

PROJECT_TITLE: 2022 In Vivo Magnetic Resonance Gordon Research Conference and Gordon Research Seminar


ORG_CITY: TRENTON

ORG_NAME: NEW JERSEY STATE DEPARTMENTR/AGRICULTURE

ORG_STATE: NJ

PHR: Project Narrative Serving a densely populated state with a diverse population of pets and livestock, the Animal Health Diagnostic Laboratory (AHDL) at the New Jersey Department of Agriculture (NJDA) has a responsibility to safeguard the health and well-being of not only the animal population, but also the human population. When animal food or drug products are contaminated, human health may be compromised either through consumption of contaminated products or by consuming ingredients used in both animal and human products. The equipment, supplies, personnel, and training supported by the co-operative agreement funding will improve the capabilities of the AHDL to a) respond to animal food and drug contamination events, potential outbreaks, and incidents needing surge capacity b) provide analytical data for regulatory purposes, and c) participate in interlaboratory method comparison, small-scale method development and/or validation, and matrix extension

PI_NAMEs: PATIL, AMAR  (contact)

PROJECT_TITLE: NJDA Animal Health Diagnostic Lab - FDA CVM Veterinary Diagnostic Program Co-operative Agreement to Protect Public Health


ORG_CITY: TROY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

PHR: Project Narrative: The broad field of biomolecular science and engineering has dramatically advanced in recent years to accommodate increased interactions of engineers and life scientists, resulting in rapid growth of synthetic biology, biomanufacturing, stem cell biotechnology and data-driven therapeutics discovery, among other advances. The Biomolecular Science and Engineering Training Program at Rensselaer Polytechnic Institute (RPI) is dedicated to the education of a broad and diverse pool of predoctoral students at the interface of biology, chemistry and engineering, focusing on the quantitative linkages that define this interface and prepare trainees for careers in biotechnology.

PI_NAMEs: VASHISHTH, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Engineering;Science;Training Programs

PROJECT_TITLE: BIOMOLECULAR SCIENCE AND ENGINEERING TRAINING PROGRAM

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Neuropilin-1 (NRP1) is recently identified to be a prognostic marker in heart failure with preserved ejection fraction (HFpEF), but its role in the disease pathogenesis and the underlying molecular mechanism are still not well understood. This proposed study aims to identify NRP1 as a novel mediator of TNFα-induced endothelial cell dysfunction and reveal how the crosstalk of NRP1 and TNFα contributes to the disease initiation and progression of HFpEF.

PI_NAMEs: WANG, YING  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Adhesions;Adult;Affect;Affinity;Antibodies;arteriole;Binding;Binding Proteins;Biological Assay;Biological Availability;Cardiac;Cardiac Myocytes;Cardiac rehabilitation;Cell Adhesion Molecules;Cell Physiology;Cells;Characteristics;Collagen;Coronary artery;Data;Deposition;Development;Disease;Disease Progression;disorder control;Docking;effective therapy;EFRAC;Endothelial Cells;endothelial dysfunction;Endothelium;Exercise;Exhibits;Functional disorder;Goals;Heart;Heart failure;Homeostasis;hospital readmission;Immunoprecipitation;Impairment;improved;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Integral Membrane Protein;Investigation;knock-down;Knock-out;Knockout Mice;Leukocytes;Ligands;Mediating;Mediator;Modeling;Molecular;mortality;mouse model;Mus;Myocardial;Myocarditis;Neuropilin-1;Nitric Oxide;NOS3 gene;novel;Pathogenesis;Pathologic;Patients;Peptides;pharmacologic;Physiological;Play;Precision therapeutics;preservation;Prognostic Marker;Publishing;receptor;Receptor Signaling;Regulation;Relaxation;response;Role;Semaphorins;Serum;Signal Pathway;Signal Transduction;small molecule;Tamoxifen;targeted treatment;Testing;Tissues;TNF gene;TNFRSF1A gene;Tumor Necrosis Factor Receptor;United States;Up-Regulation;Vascular Endothelial Growth Factors;Zebrafish

PROJECT_TITLE: Roles of neuropilin-1 in endothelial cell dysfunction

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE Pannexin (PANX1-3) are important ATP-release channels playing critically physiological roles ranging from blood pressure regulation, glucose uptake, apoptotic cell clearance, tumor metastasis, ischemia-reperfusion, human oocyte development to skin/skeleton development. The proposed study focuses on untangling the oligomeric state, channel assembly, molecular structure, gating mechanism, and pharmacology of the PANX1-3, taking advantage of single-particle cryo-EM, electrophysiology, and other functional approaches. The proposed research is relevant to public health and NIH’s mission because this work will provide a deep understanding and broaden our knowledge of the relationships between atomic structures and the complex biological and pathological functions of PANXs, paving the way for the development of therapeutics to treat pannexin-related diseases.

PI_NAMEs: LU, WEI  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Adenosine Triphosphate;Anions;Apoptotic;Binding;Binding Sites;Biochemical;Biological;Biological Assay;blood pressure regulation;Calcium;Caspase;Cells;Complex;Connexins;Consensus;Cryoelectron Microscopy;Data;Development;Disease;Dyes;Electrophysiology (science);Environment;Exocytosis;experimental study;extracellular;Family;Family member;Family Study;Foundations;Gap Junctions;glucose uptake;Human;Inflammation;Ion Channel;Ischemia;Knowledge;Link;Lipids;Mechanics;Membrane;Mission;Molecular;Molecular Structure;Neoplasm Metastasis;Nervous System;neuron development;neuroprotection;Nociception;novel therapeutics;Oocytes;particle;Pathologic;Permeability;Pharmaceutical Preparations;Pharmacology;Phosphorylation;Physiological;Physiology;Play;Potassium;Process;Public Health;receptor;Reperfusion Injury;Reperfusion Therapy;Research;Role;Signal Transduction;Site;Skeletal Development;Skin;small molecule;Solid;Structure;Synaptic Cleft;Synaptic Transmission;targeted treatment;Taste Perception;therapeutic development;therapeutic target;tumor;United States National Institutes of Health;Work

PROJECT_TITLE: Elucidating structures and molecular mechanisms of Pannexin channels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Organization of the human genome in the nucleus is critical to maintain proper gene function and specific alterations in this organization are associated with many diseases. However, the fundamental principles controlling the three-dimensional (3D) genome organization remain poorly understood. This study is important to public health and aligns with the mission of the NIGMS as it will identify the regulatory elements that control genome organization and will contribute to understand the significance of genome organization alterations in disease.

PI_NAMEs: RIVERA-MULIA, JUAN CARLOS  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3-Dimensional;Binding;bioinformatics tool;Cell Differentiation process;Cell Nucleus;cell type;Cells;Chromatin;Computer Models;Development;differentiation protocol;Disease;DNA Replication Timing;Elements;embryonic stem cell;Enhancers;Epigenetic Process;Evolution;experimental analysis;Experimental Designs;Gene Expression;gene function;gene regulatory network;Genome;genome editing;Genome engineering;Genomics;Human;human embryonic stem cell;Human Genome;Image;imaging facilities;innovation;Laboratories;Minnesota;Mission;Modeling;Mus;National Institute of General Medical Sciences;next generation sequencing;pluripotency;Positioning Attribute;Public Health;Regulatory Element;Research;Resource Sharing;Resources;stem cell differentiation;stem cells;success;Supercomputing;System;Technology;Testing;Three-dimensional analysis;Trans-Activators;transcription factor;Universities;Work

PROJECT_TITLE: Regulatory elements of replication timing and 3D genome organization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Precision Medicine;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative FDA has approved the use of immune checkpoint inhibitors in combination with chemotherapy for triple-negative breast cancer patients, however, half of the patients do not respond. The proposed research will elucidate mechanisms underlying breast cancer patient resistance to immune checkpoint inhibitors. This project will identify novel biomarkers to predict patient response and therapeutic targets to improve the efficacy and durability of immune checkpoint inhibitors.

PI_NAMEs: GAO, YANG  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Adoptive Transfer;Advocate;American;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;Basic Science;Bioinformatics;Biological;Biological Markers;Blood specimen;Breast;Breast Cancer Model;Breast Cancer Patient;cancer cell;Cancer Etiology;Cancer Patient;cancer type;career;career development;Cell Physiology;cell type;Cells;Cessation of life;checkpoint therapy;chemotherapy;Cities;Clinic;Clinical;clinical application;clinical biomarkers;clinical remission;Clinical Research;Clinical Trials;Collaborations;college;Combined Modality Therapy;Data;Dedications;Development;Distant;Educational workshop;effective therapy;Environment;experimental study;Feedback;Foundations;gain of function;Genes;genetic signature;Goals;Hospitals;Human;IFNAR1 gene;IFNGR1 gene;Immune;Immune checkpoint inhibitor;immune function;Immunity;Immunologic Memory;Immunology;Immunophenotyping;Impairment;improved;In Vitro;in vivo;inhibitor therapy;Institution;Interferon alpha;Interferons;Journals;Knock-out;Knowledge;Knowledge acquisition;Ligands;loss of function;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Medical;Medical center;Medicine;meetings;Mesothelioma;Modeling;Mouse Mammary Tumor Virus;multidisciplinary;Mus;Mutation;Myelogenous;neoplastic cell;neutrophil;next generation;novel;novel marker;Outcome;Parabiosis;patient response;Patients;peripheral blood;Phase;polyoma middle tumor antigen;Postdoctoral Fellow;Pre-Clinical Model;predicting response;Prediction of Response to Therapy;predictive marker;programmed cell death protein 1;Proteins;receptor;Renal Cell Carcinoma;Research;research and development;Research Personnel;Resistance;responders and non-responders;response;Role;Sampling;Signal Transduction;Site;skills;Spatial Distribution;T-Cell Proliferation;T-Lymphocyte;Testing;Texas;therapeutic development;Therapeutic Intervention;therapeutic target;Training;training opportunity;transcriptome;transcriptomics;translational cancer research;Translational Research;translational study;triple-negative invasive breast carcinoma;tumor;Tumor Subtype;Woman

PROJECT_TITLE: Harnessing neutrophils to improve the efficacy of immune checkpoint inhibitors in breast cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Most genetic variants that contribute to the risk or severity of common and rare diseases fall in regions of the human genome that control the expression of genes, rather than in the genes themselves. Although we have learned the hallmark characteristics of such “enhancer” regions, it has been exceedingly difficult to pinpoint which genetic variants within them are disease-contributory and which gene(s) they act through. Here we propose to leverage cutting-edge technologies to functionally test over one million candidate enhancers or variants therein for their role in modulating the expression of neighboring genes. If we are successful, this work will critically facilitate the leveraging of genetics to inform the prediction of individual disease risk, as well as the development or prioritization of therapeutic strategies that are well-supported by genetic evidence.

PI_NAMEs: AHITUV, NADAV ;KIRCHER, MARTIN ;SHENDURE, JAY ASHOK (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Affect;Biological Assay;Biological Models;Calibration;Cardiac;Cardiac Myocytes;Catalogs;cell type;Cells;Characteristics;Chromatin;combinatorial;Computer software;Coupling;Data;Data Set;data sharing;Development;directed differentiation;Disease;disorder risk;Distal;Elements;Embryo;Embryoid bodies;Enhancers;experience;experimental study;falls;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic variant;genome editing;genome-wide;genomic variation;Genomics;Goals;Heritability;Human;Human Biology;Human Development;human disease;Human Genetics;Human Genome;in vitro Model;in vivo;indexing;Individual;Leadership;Learning;Libraries;Link;Measurement;Mediating;Methods;Modeling;Mus;Mutagenesis;Mutate;Mutation;nerve stem cell;Neurologic;open source;Organoids;Penetrance;Phenotype;Population;predictive modeling;prime editing;Protocols documentation;Rare Diseases;rare variant;Regulatory Element;Reporter;Rest;Risk;Role;Severities;System;Technology;Teratoma;Testing;Therapeutic;Transcriptional Regulation;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Massively parallel characterization of variants and elements impacting transcriptional regulation in dynamic cellular systems


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE To understand the Lewy Body Dementia (LBD) pathogenesis mechanism, we must understand brain region- specific and cell-type-specific dysregulations of signaling pathways in the LBD brain. To achieve this goal, we propose to uncover region-specific and cell-type-specific dysregulations of proteome and transcriptome in the LBD brain. This study will enable us to understand the cellular signaling pathways of region-specific vulnerability to pathological α-syn in LBD. Eventually, this study will lead us to understand the LBD pathogenesis mechanism.

PI_NAMEs: KAM, TAE-IN ;KANG, SUNG UNG ;NA, CHAN-HYUN  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;alpha synuclein;Alzheimer's Disease;Amino Acids;Animal Model;Area;Astrocytes;Biochemical;Bioinformatics;Biological Models;Braak's hypothesis;Brain;Brain region;brain tissue;cell behavior;cell type;Cells;Cerebellum;Cognitive;Complex;Data;Dementia;Development;Disease;Dissection;entorhinal cortex;Event;Exhibits;Exposure to;Functional disorder;Goals;Heterogeneity;Hippocampus;Human;in vivo;Individual;insight;Investigation;Label;Lewy Bodies;Lewy Body Dementia;Lewy neurites;Limbic System;Messenger RNA;Microdissection;Microglia;Modeling;Molecular;motor symptom;mouse model;Neocortex;Nerve Degeneration;Neurites;Neurobehavioral Manifestations;neurodegenerative dementia;Neurodegenerative Disorders;neuron loss;Neurons;novel;Parkinsonian Disorders;Pathogenesis;Pathologic;Pathway interactions;Pattern;physical separation;Physiology;Population;Process;Proteins;Proteome;Research Personnel;Role;Signal Pathway;single cell analysis;single nucleus RNA-sequencing;synucleinopathy;Technology;transcriptome;Validation

PROJECT_TITLE: Region-Specific Vulnerability of the Lewy Body Dementia's Brain


ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: Effective treatments for peripheral artery disease and chronic limb ischemia are limited and leave veterans with chronic pain and possible amputation, since as a group they are at higher risk for these complications. Exposure of blood and muscle to red light increases blood flow by increasing nitric oxide through the secretion of S- nitrosothiols contained in endothelial vesicles. Understanding how light facilitates this secretion will help design new classes of drug therapies to help veterans with vascular diseases by producing a stable nitric oxide source. Further characterization of this cellular mechanism of nitric oxide release is a vital step in the expansion of red light therapy as a common treatment modality.

PI_NAMEs: LOHR, NICOLE  (contact)

PROJECT_TERMS: Adhesions;Affect;Age;American;Amputation;Arteries;arteriole;Atherosclerosis;autocrine;Binding;Blood;Blood flow;Blood Platelets;Blood Vessels;Calcium;Cell Culture Techniques;Cell membrane;Cellular Stress;Chronic;chronic pain;Clinical;clinically relevant;common treatment;comorbidity;comparison intervention;cost;Data;db/db mouse;Descriptor;design;Diabetes Mellitus;Disease;Drug Delivery Systems;drug discovery;Drug usage;effective therapy;efficacy evaluation;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;Exhibits;exosome;experimental study;Exposure to;Failure;Gastrocnemius Muscle;Generations;Health Care Costs;high risk;Human;human disease;human model;human subject;Hyperglycemia;Impairment;improved;improved outcome;In Vitro;Incidence;ineffective therapies;Intervention;Ischemia;Kidney Diseases;Knowledge;Laboratories;Leukocytes;Light;limb ischemia;limb loss;Measures;Mediating;Medical;Medicare;microvesicles;Modality;Modeling;Morbidity - disease rate;Mus;Muscle;Nitric Oxide;Nitric Oxide Synthase;Nitrite Reductase;novel;novel drug class;Operative Surgical Procedures;Oxidative Stress;Pain;Pathologic;Pathway interactions;Patients;Perfusion;Peripheral;Peripheral arterial disease;Pharmacotherapy;Phenotype;Phototherapy;Platelet aggregation;Population;prevent;Procedures;Production;Proteins;Reactive Oxygen Species;Recovery;response;S-Nitrosothiols;Severities;Smoking;Source;Sulfhydryl Compounds;symptom treatment;symptomatic improvement;Testing;Therapeutic;Tissues;traditional therapy;trafficking;Translating;trend;Vascular Diseases;Vasodilation;Vasodilator Agents;Vesicle;vesicle transport;Vesicle Transport Pathway;vesicular release;Veterans

PROJECT_TITLE: Red light mediated trafficking of microvesicles as a mechanism for vasodilation


NIH_SPENDING_CATS: Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Mismatch repair (MMR) defects cause inherited cancer susceptibility in humans, play a role in the development of a proportion of many types of sporadic human cancer and are predictive of a striking response to cancer immunotherapy using checkpoint inhibitors. This project will provide new insights into both the mechanisms of MMR and the function of the proteins that catalyze MMR. The results of this project will provide a better understanding of basic MMR mechanisms and will potentially impact the development of clinical tests for the MMR status of patients and tumors and improvements in cancer therapy.

PI_NAMEs: KOLODNER, RICHARD D (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: base;Biochemical;Biochemical Reaction;Biochemistry;Biological Models;Biology;Cancer Biology;cancer immunotherapy;cancer therapy;Cell Cycle Regulation;Cell Death;Cells;Characteristics;Chemicals;chemotherapy;clinical development;Complex;Coupled;Databases;Defect;Development;DNA;DNA biosynthesis;DNA Damage;DNA Modification Process;DNA Sequence;DNA-Directed DNA Polymerase;endonuclease;Enzymatic Biochemistry;Eukaryotic Cell;Event;Excision;EXO1 gene;experimental study;gene repair;Genes;Genetic;genetic analysis;genetic approach;Genetic Recombination;Genetic Screening;Genome;Genomic Instability;Goals;Health;helicase;Human;Human Genetics;Immune checkpoint inhibitor;Immunotherapy;improved;In Vitro;in vivo;Individual;Inherited;insight;Investigation;Kinetics;Knowledge;Link;Malignant Neoplasms;Mammals;Maps;Mediating;Methods;Mismatch Repair;Mismatch Repair Deficiency;Molecular;Monitor;Multiprotein Complexes;Mutation;novel;nuclease;Pathway interactions;Patients;Peptides;Play;PMS1 gene;Predisposition;prevent;Property;protein complex;protein function;protein protein interaction;Proteins;Reaction;reconstitution;recruit;repaired;Reporter;Resistance;response;Role;Saccharomyces cerevisiae;Signal Pathway;single molecule;Surface Plasmon Resonance;Testing;tumor;Yeasts

PROJECT_TITLE: Enzymology of Mismatch Repair in Yeast

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Mental Health;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Children undergoing hematopoietic stem cell transplantation (HSCT) -- an invasive, expensive, and life-saving procedure -- are at substantial risk for delirium, with associated morbidity and mortality. This study will define the incidence, risk factors, and outcomes of delirium in children during the peri-transplant period. By identifying modifiable factors that contribute to delirium development, this project will lead to a reduction in delirium rates, and optimize long-term outcomes after pediatric HSCT.

PI_NAMEs: TRAUBE, CHANI  (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Accounting;Acute;Admission activity;Adult;Age;Awareness;Behavior Therapy;Benzodiazepines;Caring;Child;Childhood;Clinical;Cognition;Cognitive;cohort;Collaborations;Complication;Critically ill children;Data;Data Collection;Death Rate;Delirium;Development;Diagnosis;Dose;Early Mobilizations;Engraftment;Enrollment;Ensure;Epidemiology;experience;Goals;Health;Hematopoietic Stem Cell Transplantation;high risk;Hospital Mortality;hospital readmission;Hospitalization;Hospitalized Child;Immobilization;improved;improved outcome;Incidence;Influentials;innovation;Intensive Care Units;International;Knowledge;Length of Stay;Life;life span;Link;Long-Term Effects;Longitudinal cohort study;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mission;modifiable risk;Morbidity - disease rate;mortality;Multicenter Studies;National Cancer Institute;Neurocognitive;Neuropsychology;North America;Nurses;Oncologist;Outcome;Paper;patient population;Patient risk;Patients;Pediatric Intensive Care Units;Pediatric Oncologist;Persons;Policies;Population;post-transplant;Predisposing Factor;Prevalence Study;prevent;Prevention;Prevention Guidelines;Prevention Protocols;Principal Investigator;Procedures;programs;prospective;readmission rates;Relapse;Reporting;Research;response;Risk;Risk Factors;Scientific Advances and Accomplishments;screening;Sedation procedure;sedative;Site;Social isolation;standard of care;Structural Models;Survivors;Time;tool;Training;transplant centers;Transplantation;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Delirium in Children Undergoing Hematopoietic Stem Cell Transplants

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: NARRATIVE mTOR is a central controller of cancer growth and an anticancer target. This application will test the central hypothesis that aberrant mTOR signaling promotes oncogenic chromatin remodeling through degradation of the tumor suppressor ARID1A, which is important for cancer development and response to mTOR-targeted cancer therapies.

PI_NAMEs: ZHENG, STEVEN  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: anti-cancer;Antineoplastic Agents;ARID1A gene;Cancer Biology;Cancer Patient;cancer therapy;cancer type;CCI-779;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Clinical;Complex;Data;Development;Disease;epigenetic regulation;FDA approved;FRAP1 gene;Genetic Transcription;Growth;Human;improved;in vivo;inhibitor;Knowledge;Lead;Malignant Neoplasms;Mediating;Molecular;Oncogenic;Oncology;Outcome;Pathway interactions;Pharmaceutical Preparations;Phosphorylation;Physiology;Play;Protein Kinase;Proteins;public health relevance;Publishing;Regulation;Resistance;response;Role;Serine;Signal Pathway;Signal Transduction;Sirolimus;Somatic Mutation;SWI/SNF Family Complex;targeted cancer therapy;targeted treatment;Testing;Therapeutic;therapy resistant;treatment response;tumor;Tumor Suppressor Proteins;tumorigenesis

PROJECT_TITLE: Oncogenic Chromatin Remodeling and Anticancer Mechanisms

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Increased inflammation and dysfunctional mitochondria (organelles responsible for energy transduction and signaling) coincide in a range of chronic and age-related diseases, but knowledge regarding how inflammation affects mitochondrial function remains lacking. The current application aims to identify and characterize the functional consequences of how inflammatory signaling directly – and in many cases harmfully – reprograms mitochondrial function. Successful completion of this project will improve our understanding of crosstalk between metabolism and immunity, further define how mitochondria adapt to stress, and help guide approaches seeking to restore mitochondrial function to treat human disease.

PI_NAMEs: DIVAKARUNI, AJIT  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Affect;age related chronic disease;Anabolism;Automobile Driving;Cell Physiology;cell type;Cells;cytokine;Disease;Enzymes;Genetic;Genetic Transcription;Goals;Homeostasis;Host Defense;human disease;Immunity;improved;Inflammation;Inflammatory;Innate Immune Response;Innate Immune System;insight;Interferons;Ions;Knowledge;Laboratories;Link;Lipopolysaccharides;Macrophage;Mediating;Membrane;Metabolic;Metabolic dysfunction;Metabolism;Metals;Mitochondria;mitochondrial metabolism;mouse model;novel therapeutic intervention;Organelles;Organoids;Oxidative Phosphorylation;Pathway interactions;pharmacologic;Physiology;Process;Production;programs;Signal Transduction;Stress;Toll-like receptors

PROJECT_TITLE: Cytokine-mediated reprogramming of mitochondrial function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative Abstract The 3 overarching goals of the USC Alzheimer Disease Research Center (ADRC) are: 1) Elucidate vascular contributions to Alzheimer disease (AD), 2) catalyze basic, clinical, and translational research in AD at USC, and 3) contribute expertise in vascular disease, biomarkers, and imaging to national collaborative initiatives. The ADRC is led by 3 principal investigators: Chui, Zlokovic, and Toga and comprised of 6 required cores, the required Research Education Component (REC), and 1 optional imaging core. The Administration Core provides administrative and scientific oversight across the ADRC, including fostering development projects and supporting ADRC-affiliated studies. The Clinical Core performs standardized evaluations and diagnoses using a standardized database, enrolls and follows participants in the Vascular Cohort Study (VCS) and Brain Research Study (BRS). The Data Management and Statistical Core provides study- and core-specific databases and curates our large imaging data sets as a local and national resource. The Neuropathology Core performs standardized neuropathological examinations, stores and distributes biological tissues to research investigators. The Outreach, Recruitment, and Engagement Core works closely with the Clinical Core to recruit and retain participants in VCS and BRS, especially those from under-represented minority groups, and the development of a participant-caregiver dyad database. The Biomarker Core uses state of the art methods to determine cell-and system-specific biomarkers related to the neurovascular unit, as well as to measure standard AD biomarkers. The Imaging Core provides high field (3T and 7T) MR imaging, as well as amyloid/tau PET scans. The Research Education Component is dedicated to mentoring post-doctoral students committed to the study of under- represented minority issues in Alzheimer disease and related disorders. The USC Health Science Campus is located near high Latinx catchment areas. Treatable vascular-metabolic risk factors are particularly prevalent among the Latinx population and dovetail with the research focus of the USC ADRC.

PI_NAMEs: CHUI, HELENA CHANG (contact);TOGA, ARTHUR W

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Address;Advisory Committees;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Asian;Basic Science;big data management;Biological;Biological Markers;Biological Sciences;Blood;Blood - brain barrier anatomy;Blood Vessels;Brain;brain research;California;career;Caregivers;Catchment Area;Cells;Cerebrovascular system;Clinical;Clinical Research;Clinical Trials;cohort;Cohort Studies;Coupled;data management;Data Set;Databases;Dedications;Development;Devices;Diagnosis;DNA;Doctor of Philosophy;doctoral student;education research;Enrollment;Evaluation;experience;Faculty;Finches;Fostering;Goals;Health Sciences;Home;Image;Informatics;International;Investments;large-scale imaging data;Latino;Latino Population;Latinx;Latinx population;Leadership;Los Angeles;Magnetic Resonance Imaging;Medical Genetics;member;Mentors;Metabolic;Methods;Minority;Minority Groups;neurogenetics;neuroimaging;neuropathology;Neurosciences;neurovascular unit;novel therapeutics;outreach;Participant;participant retention;Pathogenesis;Pathologic;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;Physiology;Plasma;Positioning Attribute;Positron-Emission Tomography;Postdoctoral Fellow;Principal Investigator;Productivity;programs;Recording of previous events;recruit;Research;Research Design;Research Institute;Research Personnel;research study;Resources;Risk Factors;Role;Scientist;specific biomarkers;standard measure;Standardization;Stroke;Structure;System;tau Proteins;Tissues;Training;Translational Research;treatment center;Underrepresented Minority;Underrepresented Populations;Universities;vascular contributions;Vascular Dementia;Vascular Diseases;Work

PROJECT_TITLE: Alzheimer Disease Research Center


NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: AMHERST

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative: This proposal is designed to uncover the role of neutrophils in the age-driven decline in vaccine efficacy against Streptococcus pneumoniae, the leading cause of community-acquired bacterial pneumonia in the elderly. This will allow identification of novel targets to boost memory responses in the elderly.

PI_NAMEs: BOU GHANEM, ELSA  (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: adaptive immunity;Affect;Age;age group;age related changes;age related decline;aged;Aging;Anti-Bacterial Agents;Antibodies;Antibody Formation;Antibody Response;Antigen-Presenting Cells;antimicrobial;Automobile Driving;B-Lymphocytes;Bacteria;Bacterial Pneumonia;Binding;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Clinical;clinically relevant;Coculture Techniques;Communities;community acquired pneumonia;Data;design;Economic Burden;efficacy evaluation;Elderly;Future;Goals;Health;healthy aging;Host Defense;Host resistance;Human;human old age (65+);Human Volunteers;Immune;Immune Sera;immunosenescence;Impairment;In Vitro;in vivo;Individual;Infection;Innate Immune Response;innovation;Link;Measures;Mediating;Mediator;Memory;Mission;mouse model;Mus;Natural Immunity;neutrophil;novel;old mice;pathogen;Pathway interactions;Phenotype;Pneumococcal conjugate vaccine;Pneumococcal Infections;Pneumococcal vaccine;Pneumonia;Population;Predisposition;Prevnar;recruit;response;Role;Shapes;Site;Streptococcus pneumoniae;T cell response;T-Lymphocyte;Testing;Time;time use;transcriptome sequencing;unvaccinated;Vaccinated;Vaccination;vaccine access;vaccine efficacy;vaccine response;Vaccines;Work

PROJECT_TITLE: The role of neutrophils in the age-driven decline in anti-pneumococcal vaccine responses

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine;Skin Cancer

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative Melanoma is the deadliest form of skin cancer, and its incidence is on the rise with 106,000 new cases expected in the U.S. in 2021. Although immunotherapies are revolutionizing the treatment of melanoma, they are associated with significant toxicity, and there are no clinically useful biomarkers to predict which tumors will respond to single agent or combination immunotherapies. This project will use an integrated proteogenomics approach to improve our understanding of mechanisms of resistance to ICIs to design more effective immunotherapies and combinations, and to identify potential biomarkers to select patients appropriately for single agent vs combination immunotherapies, and to predict and monitor irAEs.

PI_NAMEs: DAVAR, DIWAKAR ;PAULOVICH, AMANDA G (contact)

PROGRAM_OFFICER_NAME: HILTKE, TARA

PROJECT_TERMS: Acetylation;Address;American College of Radiology Imaging Network;anti-CTLA4;anti-PD-1;anti-PD1 antibodies;arm;Bioinformatics;Biological Assay;Biological Markers;Biometry;Biopsy;Cancer Center;cancer clinical trial;cancer immunotherapy;Clinical;clinical biomarkers;Clinical Chemistry;Clinical Data;Clinical Trials;cohort;Combination immunotherapy;Data;Data Analyses;Data Commons;design;Early treatment;Eastern Cooperative Oncology Group;Environment;experience;Formalin;Freezing;Funding;Genomics;Germ Lines;Goals;immune checkpoint blockade;Immune checkpoint inhibitor;immune-related adverse events;Immunologic Monitoring;Immunologics;immunoregulation;Immunotherapeutic agent;Immunotherapy;immunotherapy trials;improved;Incidence;Knowledge;Laboratories;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;meetings;Melanoma;Melanoma patient;multiple reaction monitoring;Paraffin Embedding;Pathology;Pathway interactions;Patient Selection;Patients;Peptides;Positioning Attribute;Post-Translational Protein Processing;potential biomarker;pre-clinical;predicting response;programmed cell death protein 1;prospective;Proteins;proteogenomics;Proteome;Proteomics;Publications;Resistance;resistance mechanism;response;Running;Skin Cancer;Southwest Oncology Group;Specimen;Testing;Tissues;Toxic effect;Training;transcriptome sequencing;transcriptomics;tumor;tumor immunology;Ubiquitin;Validation

PROJECT_TITLE: Proteogenomic studies to understand mechanisms and drivers of resistance to immunotherapies


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: HIV/AIDS;Mental Health;Pediatric

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

PHR: This training program, directed at Ph.D. and M.D. fellows, prepares trainees for independent research to address the challenge of HIV/AIDS especially among children, adolescents, and young adults under the age of 25. Faculty in the Division of Child and Adolescent Psychiatry, Providence/Boston Center for AIDS Research, Brown School of Public Health, and the Division of Infectious Disease provide research mentoring and didactic instruction on youth behavioral health and medical aspects of HIV research. Training involves interdisciplinary and translational elements to prepare trainees for the integration of the medical, psychiatric, and developmental issues informing biobehavioral HIV/AIDS Research.

PI_NAMEs: BROWN, LARRY K (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TITLE: Child/Adolescent/Young Adult HIV Research Training


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: IOWA CITY

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative  The long-term goal of this multi-institutional research is to improve patient safety by establishing simulator training and evaluation of surgical skills as essential components of orthopedic residency programs. Objectively measuring skill in the OR is a critical step toward this goal because it allows skills training to be linked to performance in surgery; skill assessment in the lab guides progress to the OR, and assessment in the OR informs skills lab methods and benchmarks. This research is innovative because it demonstrates and disseminates new skill assessment techniques critically needed to hasten improvement in resident performance, ultimately reducing costs while enhancing patient safety.

PI_NAMEs: ANDERSON, DONALD D (contact);THOMAS, GEB

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Integrating Next Generation Simulator Training and Operating Room Performance Assessment into Orthopedic Residency Programs

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: MILWAUKEE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Postnatal growth failure is a significant morbidity in very low birth weight infants and is associated with increased risk of later cardiometabolic diseases and neurodevelopmental impairment. We and others have identified in humans and animal models that early life sodium depletion contributes to impaired growth while our novel preliminary data suggests a key role for short- and long-term metabolic processes. We will address this key knowledge gap by combining novel approaches in study design, techniques and transgenic animal models to identify mechanisms by which early life Na homeostasis regulates growth and energy expenditure.

PI_NAMEs: GROBE, JUSTIN L (contact);SEGAR, JEFFREY L

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Adipose tissue;Adult;Age Months;Angiotensin Type 1a Receptor;Angiotensins;Animal Model;Animals;Area;Basal metabolic rate;Birth;Birth Weight;Body Weight decreased;Brain;Cardiometabolic Disease;cardiometabolism;cell type;Cells;Clinical;clinical practice;clinically relevant;Clozapine;Coupled;Couples;critical period;Data;Dependence;Development;dietary;Disinhibition;energy balance;Energy Metabolism;Engineering;Enteral Nutrition;Equilibrium;experience;Failure;Fatty acid glycerol esters;Growth;Health;Homeostasis;Hospitals;Human;human model;Hypothalamic structure;Impairment;improved;Infant;Intake;Intervention;Knowledge;Laboratories;Leptin;Life;Link;Macronutrients Nutrition;Mediating;Metabolic Control;Metabolic dysfunction;metabolic phenotype;Metabolism;Methodology;Micronutrients;Modeling;Modernization;Molecular Biology;Morbidity - disease rate;mouse model;Mus;Muscarinic Acetylcholine Receptor;Neurodevelopmental Disorder;Neurodevelopmental Impairment;Neurologic;neuronal cell body;Neurons;neurotransmission;Neurotransmitters;novel;novel strategies;Nutritional;Osmosis;Outcome;Oxides;Parenteral Nutrition;Peptides;Play;postnatal;Practice Guidelines;Pregnancy;Premature Infant;Production;Proteins;Publishing;Receptor Activation;Receptor Gene;Receptor Signaling;Renin-Angiotensin System;Research;Research Design;response;Risk;Rodent Model;Role;Second Messenger Systems;Serum;Signal Transduction;Sodium;Stimulus;Structure of nucleus infundibularis hypothalami;Techniques;Testing;Tissues;Transgenic Animals;Transgenic Organisms;Urine;Very Low Birth Weight Infant;Weight Gain

PROJECT_TITLE: Impact of Early Life Sodium Intake on Growth and Metabolism – Role of Hypothalamic Mechanisms

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]