NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

PHR: PROJECT NARRATIVE We propose to develop machine learning models that predict a wide range of clinical, histological, and molecular outcomes directly from histopathology images. Importantly, we will connect biomedical research and clinical efforts through the identification of enriched regulatory pathways responsible for worsening cancer outcomes. Ultimately, such efforts would augment clinical practice by giving pathologists additional diagnostic tools and molecular pathway information not previously available.

PI_NAMEs: WANG, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Antibodies;Antigen Presentation;Architecture;Automobile Driving;Biological;Biomedical Research;Biopsy;Cancer Prognosis;cancer therapy;cancer type;Cellular Morphology;Clinic;Clinical;clinical practice;clinical predictors;Collaborations;Communities;Complete Blood Count;Computing Methodologies;convolutional neural network;Data;data integration;Data Set;Decision Making;deep learning;deep learning model;density;Diagnosis;diagnostic biomarker;diagnostic tool;diagnostic value;differential expression;Disease;Disease-Free Survival;Disparate;DNA Sequence Alteration;Dreams;Endometrial Carcinoma;Genes;Genetic Transcription;Glioblastoma;Hematology;Histologic;Histology;Histopathology;illness length;Image;imaging platform;immune cell infiltrate;Immunohistochemistry;Immunophenotyping;improved;Individual;interest;Intuition;Knowledge;Knowledge Discovery;KRAS2 gene;Learning;machine learning model;machine learning prediction;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Medical;Methods;Mitotic;Modeling;Molecular;Molecular Profiling;Morphology;Multiomic Data;multiple omics;Mutation;National Cancer Institute;Neural Network Simulation;novel;Nuclear;Outcome;Pathologic;Pathologist;Pathology;Pathway interactions;Patients;Pattern;Performance;personalized diagnostics;PIK3CA gene;predict clinical outcome;predictive signature;Process;Prognosis;Proteins;proteogenomics;Proteomics;reconstitution;Regulatory Pathway;Research;Resolution;Role;Stains;Tissues;tool;TP53 gene;Training;transcriptomics;Trust;tumor;Tumor Biology;tumor heterogeneity;Tumor Pathology;Tumor stage;tumorigenesis;Urine;Validation;Visual;Visualization;Work;ZFHX3 gene

PROJECT_TITLE: Deep-learning Integration of Histopathology and Proteogenomics at a Pan-cancer Level - Resubmission

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics;Human Genome;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Type 2 diabetes (T2D) is a complex disease where the follistatin (FST) pathway has emerged as a potential mechanism impacting T2D pathophysiology, but the context-specific T2D regulation remains unclear. I will investigate genetic regulators of gene expression and chromatin structure within mesenchymal stem cells in basal and stimulatory states to elucidate genetic regulators of the FST pathway. This study will contribute to a multimodal understanding of T2D with the goal of informing future treatments.

PI_NAMEs: VENTRESCA, CHRISTA NICOLE (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: activin A;adipocyte differentiation;Adipose tissue;Affect;Beta Cell;Binding;Biological;Biopsy;Cell Line;Cell Nucleus;cell type;Cells;Chromatin;Chromatin Loop;Chromatin Structure;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR-mediated transcriptional activation;Data;Data Set;Development;Diabetes Mellitus;diabetes risk;Disease;Enhancers;Environment;Environmental Risk Factor;epigenome;Exhibits;Exposure to;falls;Follistatin;Functional disorder;Future;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;Genetic Predisposition to Disease;genetic signature;Genetic Structures;Genetic study;Genetic Transcription;Genome;genome wide association study;genome-wide;Glucose;Goals;Growth;human tissue;Individual;induced pluripotent stem cell;Inflammation;insight;Insulin;Insulin Resistance;interest;Islets of Langerhans;Knowledge;Link;Liver;Maps;Mesenchymal Differentiation;Mesenchymal Stem Cells;Metabolic;metabolome;Methods;Minority;Molecular;Molecular Conformation;mTOR inhibition;multimodality;Multiomic Data;multiple omics;Muscle;Muscle Fibers;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleic Acid Regulatory Sequences;Pathway interactions;Peripheral;precursor cell;Predisposition;prevent;promoter;Property;Proteins;Regulation;Regulator Genes;Regulatory Element;Resolution;response;Role;Sampling;screening;Signal Transduction;Single Nucleotide Polymorphism;Skeletal Muscle;Specificity;Statistical Data Interpretation;stem cell biology;stem cell genes;stem cells;Stimulus;Tissue Sample;Tissues;transcription factor;transcriptome;Translating;Untranslated RNA;Up-Regulation;Validation;Variant;Work

PROJECT_TITLE: Stimulatory state specific genetic regulatory signatures at diabetes GWAS signals


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: TEMPLE

ORG_NAME: OLIN TEAGUE VETERANS CENTER

ORG_STATE: TX

PHR: This CDA-1 project will examine the extent to which reactive aggression acts as a suicide risk factor among Veterans and test the acceptability and utility of a multimethod assessment of reactive aggression. Reactive aggression is a robust suicide risk factor among civilians, but is understudied in Veterans. Four factors limit the minimal existing research among Veterans: 1) conflation of reactive and proactive aggression; 2) use of samples underpowered to predict suicide behavior; 3) overreliance on self-report measures of aggression; and 4) inattention to Veteran cultural factors. Dr. Krauss addresses each of these limitations in the current proposal while examining the extent to which reactive aggression predicts suicide behaviors in a parent study specifically powered to predict suicide behaviors. Findings from this proposal could identify reactive aggression as a potent, modifiable risk factor for Veteran suicide, which would greatly enhance VA’s current suicide prevention efforts.

PI_NAMEs: KRAUSS, ALISON  (contact)

PROJECT_TERMS: Adaptive Behaviors;Address;Aggressive behavior;aspirate;Attention;Award;base;career;career development;Characteristics;Clinical;Clinical Trials;combat;Competence;cultural competence;Data;Data Analyses;Data Collection;design;Development;Ensure;Event;experience;Feeling hopeless;Feeling suicidal;Funding;Goals;Grant;high risk;improved;inattention;Institutional Review Boards;Intervention;Interview;K-Series Research Career Programs;Knowledge;Laboratories;Learning;Life;Link;Measures;Mental Depression;Mentors;Mentorship;Methodology;Methods;Military Personnel;Modernization;modifiable risk;Multi-Institutional Clinical Trial;Parents;Patient Self-Report;Phenotype;Physical aggression;Positioning Attribute;Prevention;Prevention program;Prevention Research;preventive intervention;prospective;Psychologist;Questionnaires;Recording of previous events;recruit;Reporting;Research;Research Methodology;Research Project Grants;response;Risk Factors;Safety;Sampling;Scientist;service member;Services;skills;Statistical Methods;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Techniques;Testing;Training;verbal;Veterans;virtual;Work

PROJECT_TITLE: Predicting Suicide Behavior Among High-Risk Veterans Using a Multimethod Assessment of Reactive Aggression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 PSYC-F (01)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHARLOTTE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

ORG_STATE: NC

PHR: Project Narrative  This study will allow us to understand how the function of a major regulatory protein (Hsp70) is controlled in by phosphorylation in response to heat shock. The scope of this work has broad implications for a variety of diseases associated with both cell signaling and molecular chaperone function, including many types of cancer.

PI_NAMEs: TRUMAN, ANDREW WILLIAM (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Ablation;amyloid formation;Binding Proteins;Biological Process;cancer type;Cell Cycle Progression;Cell Survival;Cell Wall;Cells;Cellular Stress;Client;Code;coping;Data;Disease;DNA Damage;Feedback;Future;genetic regulatory protein;Genetic Transcription;Heat Stress;Heat-Shock Response;Housekeeping;Human Pathology;In Vitro;inhibitor;Kinetics;Luciferases;MAP Kinase Signaling Pathways;MAPKinase Signaling Pathway;Mediating;Mitogen-Activated Protein Kinases;Modification;Molecular Chaperones;Mutation;Neurodegenerative Disorders;novel;Oncoproteins;Organism;Pathway interactions;Phase;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physical condensation;Physiological;Play;Predisposition;Process;protein aggregation;Protein C;Protein Family;Protein Isoforms;Proteins;Proteome;Proteomics;proteostasis;Regulation;Reporter;Research;response;Role;Signal Pathway;Signal Transduction;Site;spatiotemporal;Specificity;Stress;stress granule;Temperature;Work;Yeasts

PROJECT_TITLE: Understanding the role of Hsp70 phosphorylation in proteostasis

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ORG_CITY: STANFORD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative A complex community of microbes, known as the microbiota or microbiome, lives within our distal digestive tract and is intimately connected to human health. Diet has a major impact on the gut microbiota and different components of diet can positively or negatively impact human health via the microbiota. This project defines how specific molecular components of fermented foods impact the human gut microbiota, provide desired changes to the immune system, and prevent food allergy using a mouse model of disease.

PI_NAMEs: SONNENBURG, JUSTIN L (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Activities of Daily Living;Adult;Affect;Allergic;Anaphylaxis;Animal Disease Models;Area;Binding;Biological;Biology;Chronic;Chronic Disease;Clinical Trials;combat;Complex;Consumption;Cues;Data;Dependence;Diet;dietary;Dietary Intervention;Disease;disease model;Distal;Engraftment;experimental study;Fermentation;Food;Food Hypersensitivity;G-Protein-Coupled Receptors;Gastrointestinal tract structure;Gnotobiotic;Goals;gut microbes;gut microbiome;gut microbiota;Health;Health Promotion;host microbiota;Human;Hypersensitivity;Immune;immune function;Immune response;Immune system;Immunologics;improved;Incidence;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory marker;inflammatory modulation;Inflammatory Response;Insulin Resistance;Link;Medicine;member;Metabolic Diseases;Metabolism;metagenomic sequencing;Microbe;microbial colonization;microbial community;microbiome;microbiota;microbiota composition;Modeling;Molecular;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;nutrition;Obesity;Oral;Pathogenesis;Pathway interactions;Perception;Play;Population;Prediabetes syndrome;prevent;reconstitution;Regulatory T-Lymphocyte;Research;Role;Severities;Small Intestines;stool sample;Strategic Planning;systemic inflammatory response;Therapeutic;Therapeutic Intervention;United States National Institutes of Health;Vegetables;Work;Yogurt

PROJECT_TITLE: Impact of Diet on Intestinal Microbiota-Host Dynamics

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: NARRATIVE The pathology associated with Alzheimer’s disease (AD), β-amyloid plaques and tau neurofibrillary tangles, is frequently seen in older people with normal cognition. By measuring this pathology during life with PET scanning, it has become clear that these processes cause some individuals to show memory decline over time, while others do not. This project will investigate several possible factors that are associated with successful aging outcomes: that is, preservation of cognitive function despite the occurrence of AD pathology.

PI_NAMEs: JAGUST, WILLIAM J. (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: abeta deposition;Affect;Age;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;Atrophic;Binding;Biochemical;Biological Factors;Brain;Brain Diseases;Brain region;Cognition;Cognitive;Cognitive aging;cognitive function;Cohort Studies;Data;demographics;density;Deposition;Episodic memory;episodic memory impairment;Evaluation;falls;follow-up;Funding;Genotype;Grant;Heterogeneity;Hippocampus;Imaging Device;Impaired cognition;Impairment;improved;improved outcome;Individual;Label;Laboratories;Learning;Life;Ligands;Machine Learning;Magnetic Resonance Imaging;Maintenance;MAPT gene;Measurement;Measures;medial temporal lobe;Memory;Memory Loss;Methods;Modeling;neural;Neuropsychological Tests;normal aging;novel;novel strategies;older adult;Older Population;Outcome;Participant;Pathologic;Pathology;Performance;Persons;Phase;Positron-Emission Tomography;Prefrontal Cortex;preservation;Process;Proteins;recruit;Research;resilience;Resistance;response;Senile Plaques;Structure;super ager;Synapses;Synaptic Vesicles;tau aggregation;tau Proteins;Techniques;Testing;Thick;Time;Visit;Work

PROJECT_TITLE: Neural and Biochemical Mechanisms of Cognitive Aging

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Pediatric

ORG_CITY: IOWA CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The goal of this application is to identify and encourage trainees in internal medicine and pediatrics to pursue a mentored research experience during their residencies as a means to address the critical shortage of physician- scientists in the United States. Our mentored research training program leverages the acknowledged strengths in cardiovascular, pulmonary, hematology, and sleep research at the University of Iowa. At the completion of training, Scholars should have the clinical and research backgrounds needed to attain board eligibility in pediatrics or internal medicine, succeed in subspecialty training, and advance to faculty positions aimed at independent research careers.

PI_NAMEs: MCCRAY, PAUL B;STOLTZ, DAVID A (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Academic Medical Centers;Address;Area;Award;Basic Science;Biology;Cardiovascular Diseases;Cardiovascular system;career;Career Choice;career development;Childhood;Clinical;Clinical Research;Clinical Sciences;Clinical Skills;college;Communications Media;Competence;design;Development;Development Plans;Education;Eligibility Determination;Ensure;Environment;experience;Faculty;Fellowship;Funding;Future;Goals;Hematological Disease;Hematology;imaging facilities;Immersion;Individual;innovation;interest;Internal Medicine;International;Iowa;Leadership;Lung;Lung Diseases;lung imaging;Manuscripts;Medical;Medicine;meetings;Mentors;National Heart, Lung, and Blood Institute;Oral;Pathway interactions;Pediatrics;Physicians;Population;Positioning Attribute;posters;Preparation;programs;Publications;Recording of previous events;recruit;Research;Research Training;Residencies;Resources;role model;Scholars Program;Scientist;skills;Sleep;Sleep Disorders;Slide;success;symposium;timeline;Training;Training Programs;Translational Research;United States;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Iowa StARR Scholars Program


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Hydrocephalus;Infectious Diseases;Influenza;Neurosciences;Pediatric;Pneumonia and Influenza;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Public Health Relevance Infections, including influenza, have been linked to pediatric hydrocephalus; however, pathological progression resulting in ventricle expansion and altered brain development has not been clearly defined. The proposed project is to examine the impact post- infectious hydrocephalus has on the lateral ventricular system stem cell niche. A particular emphasis will be placed on the critical functions of ependymogenesis, neurogenesis and the capacity for regenerative repair following infection.

PI_NAMEs: CONOVER, JOANNE C (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 3-Dimensional;Address;Adhesives;Adult;Anterior;Apical;Area;astrogliosis;Brain;Cell Count;Cell Cycle;Cell Differentiation process;Cell Line;Cell surface;Cells;Cerebrospinal Fluid;Childhood;Cleaved cell;Color;Coupled;course development;Data;Development;Disease;Electroporation;Embryo;Embryonic Ventricle;Enzymes;Ependyma;Ependymal Cell;Epithelium;Experimental Designs;Fetal Development;Human;Hydrocephalus;immune activation;Immunity;improved;in utero;Infection;Influenza;Influenza A virus;influenza virus strain;influenzavirus;Injury;Intranasal Administration;Intraventricular;Intraventricular Injections;Label;Lateral;lateral ventricle;Life;Link;live cell imaging;Magnetic Resonance Imaging;Maps;Measures;Mediating;Modeling;Monitor;monolayer;mouse model;Mus;Neonatal;Neuraminidase;neurogenesis;Neuroglia;Neurons;neurovirulence;Pathogenesis;Pathologic;Positioning Attribute;postnatal;postnatal development;postnatal period;prenatal;Process;Production;programs;Property;Prosencephalon;public health relevance;Radial;reconstruction;Recovery;Regenerative capacity;regenerative repair;repaired;reparative capacity;Resistance;Resolution;response;Route;Sampling;Severities;Sialoglycoproteins;Slice;spatiotemporal;stem cell division;stem cell exhaustion;stem cell fate;stem cell function;stem cell niche;stem cell proliferation;stem cells;Subependymal;subventricular zone;Surface;Testing;Thinness;Time;treatment strategy;Variant;vector;Ventricular;ventricular system;Viral;Viral Proteins;Virus;Work;young adult

PROJECT_TITLE: Disease Mechanisms of Prenatal and Pediatric Acquired Hydrocephalus

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Cell migration is a critical step in the metastatic spread of cancerous cells from a primary tumor to distant organs in the body. To date, the vast majority of cell migration assays are carried out in medium with a viscosity close to that of water (0.77 cP), whereas the viscosity of the interstitial fluids and blood in the human body is much larger. We will herein employ state-of-the-art bioengineering and imaging tools, quantitative analysis and in vivo models, to understand how breast cancer cells sense and respond to physiological extracellular viscosities in an effort to identify novel therapeutic targets to reduce breast cancer metastasis.

PI_NAMEs: KONSTANTOPOULOS, KONSTANTINOS  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: 3-Dimensional;Actins;Actomyosin;Acute;Affect;Anterior;Biological Assay;Biomedical Engineering;Biophysics;Blood;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Patient;breast cancer survival;cancer cell;Cancerous;Cations;Cell membrane;cell motility;Cell Volumes;Cells;chloride-cotransporter potassium;Complement;confocal imaging;Crowding;Cytoplasm;Cytoskeleton;Data;Dissociation;Distant;Elements;Epithelial Cells;Event;Exhibits;Exposure to;extracellular;Extracellular Matrix;Extracellular Matrix Degradation;Feedback;Fiber;Focal Adhesions;Goals;Growth;Human body;Image;Imaging Device;In Vitro;in vivo;in vivo Model;Injections;Integrins;Intercellular Fluid;interdisciplinary approach;interstitial;Invaded;Ion Channel;Ions;Light;Liquid substance;lung colonization;macromolecule;Malignant Breast Neoplasm;mammary;Mechanics;mechanotransduction;Mediating;member;Memory;migration;Migration Assay;Modeling;Motility;Motion;Motor;mouse model;Mucins;multiphoton microscopy;Mus;Neoplasm Metastasis;Neoplasm Transplantation;neoplastic cell;new therapeutic target;novel;Nuclear Translocation;Optics;Organ;Organoids;Osmosis;particle;Pathway interactions;patient derived xenograft model;Patients;Pattern;Physiological;PIK3CG gene;Plasma;preconditioning;Primary Neoplasm;Process;Prognostic Marker;Proteins;Publishing;receptor;Regulation;Resolution;Role;Signal Transduction;Site;Speed;Stretching;Survival Analysis;Swelling;Tail;Testing;Tissues;Travel;triple-negative invasive breast carcinoma;tumor;Veins;Viscosity;Water;Zebrafish

PROJECT_TITLE: Viscotaxis: Novel cell migration mechanisms regulated by microenvironmental viscosity

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Emergency Care;Health Services;Lung;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Most patients that require mechanical ventilation in the emergency department (ED) either die or have long term disability if they survive. ED clinicians commonly administer sedative and paralytic medications to facilitate endotracheal intubation (i.e. placement of a breathing tube), and to care for patients after mechanical ventilation has been initiated; however, our findings suggest that these practices increase the rate of awareness with paralysis, a dreaded complication whereby patients have memories of wakeful paralysis. By studying awareness with paralysis, post-traumatic stress disorder, and patient-centered experiences among survivors of acute respiratory failure, this project will have important implications for how mechanically ventilated ED patients are treated worldwide.

PI_NAMEs: FULLER, BRIAN M (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Accident and Emergency department;Acute respiratory failure;Attenuated;Awareness;Breathing;Caring;Clinical Trials;clinically significant;Cluster randomized trial;cohort;Collaborations;Complication;Critical Care;Critical Illness;critical period;Data;design;Development;Emergency Department patient;Event;Exclusion;experience;Exposure to;Frequencies;Future;Goals;Hospitalization;Hospitals;improved;improved outcome;Induction of neuromuscular blockade;Infrastructure;Intensive Care Units;Intervention;Intratracheal Intubation;Intubation;Investigation;Investments;Knowledge;lens;Link;Literature;Long term disability;Low Prevalence;Mechanical ventilation;Medical;Memory;memory recall;Mental Health;Methods;Morbidity - disease rate;Neuromuscular Blocking Agents;Odds Ratio;Operating Rooms;Outcome;Outcome Measure;Paralysed;Pathway interactions;Patient Care;patient oriented;patient safety;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Post-Traumatic Stress Disorders;pragmatic intervention;Prevalence;prevent;Prevention;Prevention strategy;primary outcome;psychologic;psychological outcomes;Public Health;Respiratory Failure;Risk Factors;Role;sedative;sound;Survivors;Symptoms;Testing;Time;Traumatic injury;Tube;ventilation;Wakefulness;Work

PROJECT_TITLE: Awareness with Paralysis and Post-Traumatic Stress Disorder among Mechanically Ventilated Emergency Department Survivors: The ED-AWARENESS-2 Study

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Infectious Diseases;Lung;Organ Transplantation;Pulmonary Fibrosis;Rare Diseases;Transplantation

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Our work shows that the majority of patients with idiopathic pulmonary fibrosis (IPF), the leading indication for lung transplantation, have short telomeres. Our studies have also shown that patients with short telomeres have impaired T cell immunity leading to increased susceptibility to complications from Cytomegalovirus and other viral infections, but continue to be at similar risk for chronic rejection (chronic lung allograft dysfunction; CLAD). Our proposal studies how telomere genetics impact immune mechanisms that drive these outcomes and will leverage the largest lung transplant cohort (LTOG) to evaluate outcomes, leading to new insights that will significantly advance the field of lung transplantation. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: ALDER, JONATHAN K.;MCDYER, JOHN F (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute;adaptive immunity;Age;allograft rejection;Allografting;Biological;Bronchoalveolar Lavage;Brush Cell;Caring;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Aging;Cell Physiology;Chronic;Clinical;cohort;Complex;Complication;Cytomegalovirus;Cytomegalovirus Infections;Data;Defect;Disease;Flow Cytometry;Functional disorder;Gene Expression Profile;Genes;Genetic;genetic variant;genome sequencing;Germ-Line Mutation;Host Defense;Human Herpesvirus 4;idiopathic pulmonary fibrosis;Immune;Immune response;Immune system;Immunity;Immunologics;immunosenescence;Immunosuppression;Impairment;improved;In Vitro;Individual;insight;Knowledge;Length;Lung;lung allograft;Lung Diseases;Lung Transplantation;Lymphoproliferative Disorders;Measures;Mediating;Molecular;Mutation;North America;Outcome;Pathogenicity;Patients;Peripheral Blood Mononuclear Cell;Phenotype;post-transplant;Predisposition;Publishing;Pulmonary Fibrosis;rare variant;Reporting;response;Risk;Role;Sampling;senescence;single-cell RNA sequencing;Syndrome;T-Lymphocyte;telomere;Telomere Maintenance;Telomere Maintenance Gene;Testing;Therapeutic;transcriptome;transcriptome sequencing;Transplant Recipients;Transplantation;Universities;Viral;Virus Diseases;whole genome;Work

PROJECT_TITLE: The Role of Telomeres in Lung Transplant Recipient Immunity and Outcomes

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: EUGENE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative The proposed project is relevant to public health because the Drosophila neural stem cell lineages we study are essentially the same type of lineage as human outer radial glial (oRG) progenitors. This pool of human progenitors is proposed to generate the massive cortical expansion in most primates, yet working with human progenitors has limitations. Our system provides a gene and mechanism discovery system which will allow tightly focused hypotheses for the role of human oRGs in generating cortical neural diversity in development or disease. Thus, the proposed research is relevant to NIH's mission to reduce the burden to society arising from prevalent environmental and genetic brain disorders.

PI_NAMEs: DOE, CHRIS Q (contact)

PROGRAM_OFFICER_NAME: KOSTER, MARANKE IRENE

PROJECT_TERMS: Address;Adult;Bees;Brain;Brain Diseases;Brain region;brain size;brain tissue;Butterflies;Cell Lineage;Cerebral cortex;Complex;Date of birth;Development;Disease;Drosophila genus;fetal;Fishes;fly;Genes;Genetic;Human;human stem cells;Insecta;insight;Life;Mission;Modeling;Molecular;Mus;nerve stem cell;neural;neuroblast;neurogenesis;Neuroglia;Neurons;Organoids;Population;Primates;progenitor;Public Health;Radial;Research;RNA-Binding Proteins;Role;Series;Societies;Specific qualifier value;stem cells;subventricular zone;System;Testing;Tissues;transcription factor;United States National Institutes of Health

PROJECT_TITLE: Genetic and Molecular Studies of Neurogenesis

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Cardiovascular;Digestive Diseases;Heart Disease;Liver Disease;Nutrition

ORG_DEPT: PEDIATRICS

PHR: Project Narrative Long-chain fatty acid oxidation disorders are identified at birth through newborn screening. They are currently treated using medium-chain fatty acids to bypass the enzymatic defects and provide energy, but this therapy is only partially effective in heart and not effective in muscle. The proposed research seeks to optimize the type of medium-chain lipid and the route of administration in order to better treat muscle and heart.

PI_NAMEs: GOETZMAN, ERIC S (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: absorption;Acyl Coenzyme A;acylcarnitine;Affect;Biodistribution;Bioenergetics;Biological Availability;Biology;Birth;Bypass;C10;Carbohydrates;Cardiac;Cardiac Myocytes;Cardiomyopathies;Carnitine;Carnitine O-Acetyltransferase;Cells;Consumption;Data;Defect;Devices;Diet;Disease;Dose;Drug Delivery Systems;efficacy evaluation;Enzymes;exercise capacity;Fasting;Fatty acid glycerol esters;fatty acid oxidation;Future;Heart;Heart Mitochondria;Hepatocyte;Human;improved;Individual;ketogenesis;Ketones;Lipids;Liver;Liver Mitochondria;long chain fatty acid;Measures;Medium chain fatty acid;Mitochondria;Mitochondrial Matrix;mouse model;Mus;Muscle;Muscle function;Muscle Mitochondria;Neonatal Screening;Oils;Oral;Oral Administration;Patients;preclinical efficacy;Preclinical Testing;preference;Refractory;Research;Rhabdomyolysis;Route;screening program;Self Administration;subcutaneous;Subcutaneous Injections;Symptoms;Technology;Testing;Therapeutic;Tissues;Treatment Efficacy;usability;wearable device

PROJECT_TITLE: Optimizing medium-chain lipids for the treatment of long-chain fatty acid oxidation disorders

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Genetics;Health Services;Lung;Pain Research;Patient Safety;Pediatric

PHR: PROJECT NARRATIVE Clinicians caring for critically ill children routinely struggle to harmonize the tension between giving too much versus too little sedation-analgesia. This work will (1) identify patterns of sedation-analgesia associated with outcome; (2) identify genotypes associated with sedation-analgesia administration; (3) characterize PK parameters of common sedative-analgesic mediations; and (4) promote the development of the PI as an independent Learning Health System researcher. The aggregate results of this work will inform development of a predictive model for sedation-analgesia dose response for critically ill children that will be the focus of future, prospective investigations

PI_NAMEs: HORVAT, CHRISTOPHER MICHAEL (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Absence of pain sensation;Acute;Adverse effects;Adverse event;Affect;airway obstruction;Analgesics;Anxiety;biobank;Blood specimen;career development;Caring;Child;Clinical;cohort;comparative effectiveness;Continuous Infusion;conventional dosing;Critical Care;Critical Illness;Critically ill children;Data;data modeling;Delirium;Dependence;Deterioration;Development;Development Plans;Dexmedetomidine;Disease;Dose;Drug Addiction;Drug Kinetics;Drug Tolerance;Electronic Health Record;Ensure;Environmental Risk Factor;expectation;experience;Exposure to;Fentanyl;Functional disorder;Future;Genes;Genotype;genotyped patients;Growth;healing;health related quality of life;Health system;Healthcare;heuristics;Hospitalization;Iatrogenesis;Impairment;improved;in silico;Injury;Intensive Care Units;inter-individual variation;Intervention;Investigation;Learning;Life;Link;Machine Learning;mathematical model;Mechanical ventilation;Mediation;medication administration;Modeling;Morbidity - disease rate;neurodevelopment;Noise;Opioid;Organ;Outcome;Pain;patient response;Patient-Focused Outcomes;Patients;Pattern;Pediatric Intensive Care Units;Pharmaceutical Preparations;Pharmacodynamics;Pharmacogenomics;pharmacokinetic model;Phenotype;Physiological;Population;predictive modeling;Procedures;prospective;randomized trial;Reaction;Recovery;Regimen;Research Personnel;Respiratory Failure;response;routine care;Safety;Sedation procedure;sedative;self-directed learning;Single Nucleotide Polymorphism;Speed;Time;Titrations;treatment as usual;trial comparing;United States;Work

PROJECT_TITLE: A Learning Health System Approach to Precision Sedation and Analgesia in Critically-Ill Children

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Schizophrenia;Serious Mental Illness

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Africa, the birthplace of modern humans, is the single most informative continent for understanding the human genome and human disorders with worldwide impact. Since most genomic research has not involved African populations, generations of human genetic history are missing from our understanding of human genetics and complex disease. In this study, we will use novel whole genome sequencing strategies to characterize the genetic bases of schizophrenia in the Xhosa population of South Africa.

PI_NAMEs: GULSUNER, SULEYMAN ;KING, MARY-CLAIRE  (contact);MCCLELLAN, JON M;WALSH, TOMAS D

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Africa;African;African ancestry;Age;Alleles;base;Binding;Blood;Brain;Cell Line;Code;Complex;Consent;Copy Number Polymorphism;Custom;Detection;Diagnosis;Disease;DNA Transposable Elements;Enhancers;Enrollment;experience;Gender;Generations;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic study;Genetic Variation;genome sequencing;Genomic DNA;Genomics;Genotype;Goals;Grant;Human;Human Genetics;Human Genome;human genomics;human reference genome;Human Resources;Individual;Infrastructure;insertion/deletion mutation;International;international partnership;Link;Location;lymphoblast;Modeling;Modernization;Mutation;New York;novel;Participant;Phase;Phenotype;Point Mutation;Population;Privatization;Productivity;promoter;Protocols documentation;Recording of previous events;recruit;Regulatory Element;Research;Research Personnel;response;risk variant;Role;Sample Size;Sampling;Schizophrenia;Science;screening;Signal Transduction;Site;SNP array;South Africa;South African;Structure;study population;Synapses;synaptic function;Technology;Testing;transcription factor;Universities;Untranslated RNA;Variant;Washington;whole genome

PROJECT_TITLE: 1/3 Genomics of Schizophrenia in the South African Xhosa


NIH_SPENDING_CATS: Genetics;Neurosciences;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: There is currently no effective treatment for motor neuron disorders like amyotrophic lateral sclerosis and spinal muscular atrophy, in part due to a lack of understanding of the molecular mechanisms that enable distinct motor neuron subtypes to acquire and maintain their unique functional features. This proposal aims to test the hypothesis that motor neuron subtype-specific functional features, such as expression of ion channels and neurotransmitter receptors, are induced during development and maintained throughout life through the activity of highly conserved proteins of the Collier/Olf/Ebf and Hox family of transcription factors. Completion of the proposed experiments may provide novel entry points into the etiology, diagnosis, or treatment of motor neuron disorders.

PI_NAMEs: KRATSIOS, PASCHALIS  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Adult;Affect;Amyotrophic Lateral Sclerosis;Anterior;Auxins;Behavioral;Binding Sites;Biological Models;Caenorhabditis elegans;Cell Adhesion Molecules;cholinergic;Cholinergic Receptors;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cofactor;Data;Defect;Development;Diagnosis;Disease;Disease susceptibility;DNA Binding;effective therapy;Ensure;Etiology;experimental study;Family;Genes;Genetic Models;genome editing;Goals;Homeobox Genes;House mice;HOX protein;Human;Human Pathology;insight;Invertebrates;Ion Channel;knock-down;Knowledge;Life;Maintenance;model organism;Molecular;Morphology;motor neuron development;motor neuron function;Motor Neurons;Mus;Mutagenesis;Nematoda;Nerve;Nervous System;Neurons;Neuropeptides;Neurotransmitter Receptor;novel;novel strategies;Orthologous Gene;postnatal;Predisposition;Property;Proteins;Receptor Gene;Role;Signaling Molecule;Spinal;Spinal Cord;Spinal Muscular Atrophy;Synapses;System;Testing;transcription factor;Transcriptional Regulation;transcriptome sequencing;Work

PROJECT_TITLE: Hox-dependent mechanisms for establishment and maintenance of motor neuron terminal identity


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Hematology;Immunotherapy;Neurosciences;Rare Diseases

ORG_DEPT: NEUROSURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE  The selective infiltration of immunosuppressive myeloid cells is a hallmark of malignant brain tumors, and represents a major hurdle to effective immunotherapy. Our preliminary data suggest that tumor-associated myeloid cells (TAMCs) utilize two different metabolic pathways to consume arginine which has the potential to be targeted to prevent immunosuppression. This proposal seeks to dissect the unique metabolic pathways of TAMCs and target them in a clinically relevant manner to promote immunotherapy for glioma.

PI_NAMEs: LESNIAK, MACIEJ S (contact);MISKA, JASON

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adipocytes;Anabolism;Animal Model;Animals;anti-PD-1;Antitumor Response;arginase;Arginine;Basic Science;Biology;blood-brain barrier permeabilization;Brain;Brain Neoplasms;cancer infiltrating T cells;Carbon;Catabolism;Cell Physiology;Cell Survival;Cells;checkpoint therapy;Clinical;clinically relevant;Communication;conditional knockout;Consumption;Creatine;Creatine Kinase;Data;Effectiveness;Enzymes;experimental study;Generations;Genetic;Genetically Engineered Mouse;Glioblastoma;Glioma;Goals;Growth;Hypoxia;Immune;Immune Cell Suppression;Immunosuppression;Immunotherapy;improved;Infiltration;inhibitor;knockout animal;Laboratories;Macrophage;Maintenance;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Nitrogen;Ornithine;Ornithine Decarboxylase;Ovary;Pathway interactions;pharmacologic;Phenotype;Plants;Polyamines;preference;prevent;Reporting;Role;Signal Transduction;Site;standard of care;synergism;T cell infiltration;T-Lymphocyte;Testing;Testis;therapeutic target;transcriptome sequencing;translational approach;tumor;tumor growth;Tumor Immunity;tumor metabolism;tumor microenvironment;Tumor-associated macrophages;uptake;Vascularization;Work

PROJECT_TITLE: Arginine Metabolism Regulates Myeloid Immune Suppression in Glioblastoma


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD)

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Most youth who experience significant trauma-related symptoms do not receive indicated services and, when they do, the services received are not evidence-based. The current project aims to simultaneously test the effectiveness of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) for students in schools and the impact of The Beliefs and Attitudes for Successful Implementation in Schools (BASIS) strategy on clinician use of TF-CBT. If effective, TF-CBT and BASIS represent robust and generalizable strategies for greatly enhancing the accessibility and quality of services for trauma-exposed youth.

PI_NAMEs: LYON, AARON ROBERT (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Adoption;Adult;Anxiety;attentional control;Attitude;Behavior;behavior change;Belief;Child;Child Mental Health;Clinical;Cognition;Cognitive;Cognitive Therapy;Community Practice;community setting;Consultations;cost;Cost Analysis;cost effective;cost effectiveness;cost-effectiveness evaluation;Data Collection;design;Education;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation trial;efficacious treatment;evidence base;Evidence based treatment;experience;Exposure to;Fright;Health Benefit;health care delivery;hybrid type 2 trial;Hybrids;implementation barriers;implementation outcomes;implementation strategy;improved;Individual;innovation;Intervention;Knowledge;Leadership;Maintenance;Mediation;Mental Depression;Mental Health;Mental Health Services;Methods;Modeling;Motivation;National Institute of Mental Health;Outcome;Policies;Post-Traumatic Stress Disorders;practice setting;pragmatic implementation;Procedures;Provider;provider adoption;provider behavior;Public Health;randomized trial;Research;Residual state;Rest;Sampling;Schools;Self Efficacy;service delivery;Services;Shame;social norm;Social Perception;Stimulus;Students;Symptoms;Testing;theories;Time;Training;Trauma;trauma exposure;traumatic event;treatment as usual;uptake;Variant;Youth

PROJECT_TITLE: A Hybrid Type 2 Trial of Trauma-Focused Cognitive Behavioral Therapy and a Pragmatic Individual-Level Implementation Strategy

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Lung;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine

PHR: PROJECT NARRATIVE Acute and chronic lung diseases such as the acute respiratory distress syndrome (ARDS) and idiopathic pulmonary fibrosis (IPF) result from injury to the alveolar epithelium with ineffectual regeneration. Unfortunately, effective therapies are limited, in large part because our understanding of disease pathogenesis is incomplete. By dissecting mechanisms underlying alveolar homeostasis and normal regeneration, and how these go awry in disease pathogenesis, the proposed work will fill fundamental gaps in our knowledge and overcome critical barriers to the development of novel therapies for ARDS and IPF.

PI_NAMEs: ZEMANS, RACHEL LYNNE (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Alveolar;Alveolar Cell;alveolar epithelium;alveolar homeostasis;Alveolar Macrophages;Alveolus;Automobile Driving;Cells;Chronic;Chronic lung disease;Clinical;Collaborations;Dedications;Defect;Development;Disease;effective therapy;Epithelial Cell Proliferation;Epithelial Cells;epithelial injury;epithelium regeneration;Fibroblasts;Fibrosis;Funding;Health;Homeostasis;Human;idiopathic pulmonary fibrosis;Impairment;Injury;Investigation;knockout gene;Knowledge;Lung Diseases;lung injury;Mentorship;Mission;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Natural regeneration;Nature;novel;novel therapeutics;Organism;Pathogenesis;Pathologic;Permeability;Physiological;Process;progenitor;Pulmonary Fibrosis;Recovery;regenerative;Services;Time;Transitional Cell;United States National Institutes of Health;Work

PROJECT_TITLE: Mechanisms of Alveolar Homeostasis, Injury, Regeneration, and Fibrosis


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Precision Medicine;Social Determinants of Health;Wound Healing and Care

PHR: PROJECT NARRATIVE This project has major public health relevance because diabetic foot ulcers (DFUs) remain one of the most common complications of diabetes and are the leading cause of lower extremity amputations in the US. Current treatments are ineffective and given the recent surge in major lower extremity amputations in patients with diabetes despite the previous decades of decline, identification of novel treatment avenues is of critical importance. The main objectives of the Diabetic Foot Clinical Research Unit at the University of Michigan are to expand the work and activities initiated during the first DFC cycle by integrating the robust DFC infrastructure we built at Michigan with the highly skilled clinical and translational research team to: finalize the ongoing DFU biomarkers protocols, implement the DFC master protocol and its various substudies, continue our high recruitment performance across all biomarker studies, recruit, train and supervise satellite sub sites, develop new methods to stimulate participants engagement, collect all data sets from large and standardized clinical samples collections, phenotyping, genomic, molecular and microbiome analyses from DFUs samples, and wound image analyses, to patient reported outcomes and social determinants of health, analyze how DFU recommended standards of care are implemented into usual care to facilitate evolution of clinical practice, and participate in biomarker validation analyses and any new wound healing projects undertaken by the Consortium through active and effective participation in its self-governing committees.

PI_NAMEs: BUSUI (POP-BUSUI), RODICA ;HOLMES, CRYSTAL MURRAY (contact);SCHMIDT, BRIAN M

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Adherence;Adoption;Affect;American;Amputation;Ancillary Study;bench to bedside;biobank;Bioinformatics;Biological;Biological Markers;biological standardization;biomarker discovery;biomarker validation;c-myc Genes;Caring;Cells;Clinic;Clinical;Clinical Data;clinical practice;Clinical Protocols;Clinical Research;clinical research site;Clinical Skills;comorbidity;Complications of Diabetes Mellitus;cost;Data;Data Collection;data mining;Death Rate;design;diabetes management;Diabetes Mellitus;Diabetic Foot;Diabetic Foot Ulcer;driving force;economic impact;Eligibility Determination;Ensure;Evolution;foot;Funding;Future;genetic analysis;Genomics;Goals;healing;Health Care Costs;Health system;Healthcare;Heterogeneity;Human;Image;Image Analysis;Incidence;ineffective therapies;Infrastructure;instrument;interdisciplinary approach;Interdisciplinary Study;large datasets;Lead;Leadership;Lower Extremity;Machine Learning;member;metagenomic sequencing;Methods;Michigan;microbiome;microbiome analysis;Molecular;Molecular Analysis;mortality;Multi-site clinical study;National Institute of Diabetes and Digestive and Kidney Diseases;novel;novel therapeutics;Outcome;pandemic disease;Participant;patient engagement;Patient Outcomes Assessments;Patient Recruitments;Patients;Performance;personalized medicine;Persons;Phenotype;Podiatry;point of care;Policies;Precision Health;prediction algorithm;predictive marker;Prevalence;Prevention;Protocols documentation;public health relevance;Publications;Recommendation;Records;recruit;Recurrence;Research;Research Infrastructure;Rest;Risk;Role;sample collection;Sampling;Science;Site;social health determinants;socioeconomics;standard care;Standardization;success;team-based care;Techniques;tool;Training;transcriptomics;Translating;Translational Research;treatment as usual;Treatment Cost;treatment strategy;United States;Universities;Water;Work;wound;wound care;wound healing;wound treatment;Writing

PROJECT_TITLE: NIDDK Diabetic Foot Consortium Clinical Research Unit


ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: Project Narrative The role of RB1 loss in bladder cancer progression, differentiation and cancer cell plasticity remains unknown. A major obstacle in translational bladder cancer research is the lack of genetically engineered mouse models that recapitulate aggressive muscle invasive bladder cancer in humans, that makes it difficult to rigorously study in vivo responses to systemic treatment. The proposed research will utilize novel mouse models to elucidate the role of RB1 loss in tumor progression, differentiation, plasticity and resulting clinical therapeutic implications.

PI_NAMEs: LI, QIANG  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acceleration;acquired drug resistance;Adenoviruses;Adjuvant Chemotherapy;analysis pipeline;anti-cancer research;Basal Cell;Bioinformatics;Biological;Bladder;Bladder Neoplasm;Bladder Urothelium;Cancer Biology;cancer cell;Cancer Model;Cancer Patient;cancer subtypes;cancer type;career;career development;Cell Cycle Regulation;Cells;Characteristics;chemotherapy;Cisplatin;Clinical;Clinical Research;Clinical Trials;clinically relevant;Clonal Evolution;Comprehensive Cancer Center;Data;Development;Disease;DNA Repair;Doxycycline;driver mutation;Drug resistance;Engineering;experience;experimental analysis;Experimental Models;experimental study;Foundations;Future;gene repair;Genes;genetic manipulation;Genetically Engineered Mouse;Genomics;Goals;Histologic;Histology;Human;human old age (65+);in vivo;Incidence;Intravesical Administration;Keratin;keratin 5;Knock-out;Knockout Mice;Knowledge;Link;Lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mentors;Modeling;Molecular;Molecular Probes;molecular subtypes;mouse model;Mus;Muscle Cells;muscle invasive bladder cancer;Mutation;mutational status;Neoadjuvant Therapy;Neoplasm Metastasis;novel;novel therapeutic intervention;Nucleotide Excision Repair;Oncology;Operative Surgical Procedures;Organoids;Papillary Neoplasm;Pathogenesis;Pathologic;Pathway interactions;Patients;Phase;Phenotype;Physicians;PI3K/AKT;potential biomarker;pre-clinical;Pre-Clinical Model;professor;Program Development;programs;promoter;Prostate;PTEN gene;RB1 gene;Research;Research Project Grants;Resistance;response;Role;Scientist;Signal Pathway;Signal Transduction;standard care;System;Techniques;Testing;Tetracyclines;Therapeutic;therapy resistant;tool;TP53 gene;Training;Trans-Activators;Transgenic Mice;translational cancer research;treatment response;tumor;tumor heterogeneity;tumor initiation;tumor progression;Tumor Promotion;Tumor Suppressor Genes;Tumor-Derived;tumorigenesis;UPK2 gene;Urology;Urothelium;Vision;Work

PROJECT_TITLE: Therapeutic implication of RB1 loss in bladder cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Cancer;Clinical Research;Patient Safety;Precision Medicine;Prevention;Rare Diseases;Scleroderma

PHR: PROJECT NARRATIVE Scleroderma is a complex rheumatic disease with significant variability in clinical presentation, disease course, response to therapy and prognosis. This proposal will develop methods to identify patients at risk of progression who may benefit from earlier and more intensive disease monitoring and therapeutic strategies. This includes approaches to generate personalized risk estimates of major complications from multivariate longitudinal data, display predicted risk estimates in a clinical setting to test their impact on future medical decision making, and utilize phenotypic trajectories as a platform for biomarker discovery to further improve risk stratification in scleroderma.

PI_NAMEs: SHAH, AMI AALOK (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Address;Algorithms;anti-cancer;Autoantibodies;Autoantigens;Autoimmunity;Back;Biologic Characteristic;Biological Markers;biomarker discovery;Blood Vessels;Body System;Cancer Model;cancer risk;candidate identification;candidate marker;carcinogenesis;career;career development;Characteristics;Clinical;clinical care;Clinical Data;clinical decision-making;clinical practice;clinically relevant;cohort;Complex;complex data;Computing Methodologies;cross reactivity;cytokine;Data;Data Analyses;data visualization;Decision Making;Diagnosis;Diagnostic;Diffusion;Disease;Disease Progression;Event;Foundations;Future;Genes;Growth and Development function;Heterogeneity;Immune response;implementation science;improved;Individual;individual patient;innovation;insight;Kidney;Knowledge;Learning;Logistic Regressions;Malignant Neoplasms;Medical;medical schools;Medicine;Methodology;Methods;mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;Modeling;Monitor;multidimensional data;Mutation;novel;novel marker;Outcome;Pathogenesis;Pathway interactions;patient oriented research;Patient risk;patient subsets;Patients;Phenotype;Population;precision medicine;Precision Medicine Initiative;prediction algorithm;Predictive Analytics;primary outcome;Probability;Prognosis;programs;progression risk;Provider;Pulmonary Heart Disease;response;Rheumatism;Rheumatology;Risk;Risk Estimate;Risk Factors;risk prediction;risk stratification;Scholarship;Scleroderma;screening;skills;Skin;skin disorder;Somatic Mutation;Subgroup;Symptoms;System;Systemic Scleroderma;Systolic Pressure;Testing;Therapeutic;Time;tool;treatment response;treatment strategy;trend;Universities;Update;Ventricular;Visualization;Visualization software;Vital capacity

PROJECT_TITLE: Harnessing multivariate patient- and population-level disease trajectories to predict major clinical events in scleroderma

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Hematology;Infectious Diseases;Lung;Rare Diseases;Sepsis

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Sepsis is an extreme immune response of the body to severe infection and can frequently be fatal. Even though sepsis often results in low blood counts, including anemia, blood transfusion is not usually beneficial to these patients. In this project, we use human blood samples and mouse models to study how vital oxygen-carrying red blood cells change unfavorably in sepsis, and we test the ability of available methods to increase the ability of transfused blood to improve survival and other outcomes in patients with sepsis and anemia.

PI_NAMEs: DOCTOR, ALLAN ;MCMAHON, TIMOTHY J (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Adenine;Adhesions;Adhesives;Adult;Anemia;Attenuated;biobank;Blood;Blood flow;Blood specimen;Blood Transfusion;Blood Vessels;Caliber;candidate identification;Cardiac Output;cecal ligation puncture;cell injury;cell type;Cells;Child;Clinical;clinical investigation;clinical translation;clinically relevant;Consumption;Coupling;Critical Illness;Cryopreserved Cell;Depressed mood;design;empowerment;Endothelial Cells;Endothelium;Ensure;Erythrocyte Transfusion;Erythrocytes;experimental study;Exposure to;Functional disorder;Genetic;genetic approach;Hemoglobin;Homeostasis;Human;Hypoxemia;Hypoxia;Immune response;Impairment;improved;In Vitro;in vivo;Incubated;Infection;Inflammation;Influenza;inorganic phosphate;Inosine;insight;Intervention;Investigation;lead candidate;Leukocytes;Lung;Mediating;Mediator;Metabolic;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;novel;Oral;Organ;Outcome;Oxygen;Patients;Peripheral;Persons;pharmacologic;Phase;Phenotype;preservation;prospective;Pyruvate;Pyruvate Kinase;Respiration Disorders;respiratory;Respiratory physiology;response;Risk;Risk Factors;Role;Sampling;Scheme;Sepsis;septic;Signal Transduction;Site;Specimen;Testing;Therapeutic;tissue oxygenation;Tissues;Transfusion;Translations;uptake

PROJECT_TITLE: Red blood cell ATP export and transfusion in sepsis

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Chronic Pain;Mental Health;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Peripheral Neuropathy;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_NAME: ANAGIN

ORG_STATE: IN

PHR: Project Narrative Chronic pain is a major health crisis for millions of Americans in part due to ineffective treatments with significant side effects. Our non-opioid approach targets a specific pathway which we believe will lead to new drugs that are safe and effective. We have assembled a team of highly experienced researchers to solve this difficult problem and advance these new compounds toward clinical trials.

PI_NAMEs: FLORIO, STEPHANIE K (contact)

PROGRAM_OFFICER_NAME: CYWIN, CHARLES L

PROJECT_TERMS: addiction;addiction liability;Address;Adverse effects;Adverse reactions;Affect;American;Analgesics;analog;Animal Model;antagonist;anti-epileptic agents;Behavioral;Behavioral Model;Biological;Biological Assay;Brain;Canis familiaris;Cells;Central Nervous System;Central Nervous System Diseases;central sensitization;Chemicals;Chromosome abnormality;chronic neuropathic pain;chronic pain;Clinic;Clinical;clinical candidate;Clinical Trials;Complex;cost estimate;Data;design;Development;Dose;Drug Targeting;Exhibits;experience;functional group;Funding;gabapentin;genotoxicity;Glutamates;good laboratory practice;hazard;Health;health care availability;Healthcare Systems;Hepatotoxicity;high risk;improved;In Vitro;in vitro Assay;in vivo;ineffective therapies;inhibitor;Lead;lead optimization;Lesion;Life;Literature;Maintenance;Mediating;Membrane;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Nerve Degeneration;neural network;neuron loss;Neurons;neuropsychiatry;Nitric Oxide Synthase Type I;No-Observed-Adverse-Effect Level;non-opioid analgesic;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutics;Opiate Addiction;Opioid;opioid epidemic;Oral;Pain;pain model;painful neuropathy;Pathologic;Pathologic Processes;Pathway interactions;patient subsets;Penetration;Peptides;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;phase 1 study;Post-Traumatic Stress Disorders;postsynaptic density protein;pre-clinical;Pre-Clinical Model;pregabalin;Process;Property;protein protein interaction;Proteins;Publishing;Rattus;receptor;Receptor Activation;receptor binding;Receptor Signaling;recruit;Research Personnel;respiratory;Risk;Safety;safety study;Scaffolding Protein;Series;side effect;Signal Pathway;Signal Transduction;Small Business Innovation Research Grant;small molecule;socioeconomics;Specificity;Steroids;Stroke;stroke model;Testing;Therapeutic;Therapeutic Index;tool;Toxic effect;Toxicology;Traumatic Brain Injury;Triage;United States;Validation;Work

PROJECT_TITLE: Discovery of PSD95 protein-protein interaction inhibitors as novel non-opioid analgesics


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Bioengineering;Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE Amyotrophic lateral sclerosis (ALS) is a devastating and fatal disorder with no cure and few effective treatment options. We will develop a gene therapy for ALS by engineering an RNA-targeting CRISPR-based technology to silence the production of mutant forms of superoxide dismutase 1, a protein responsible for ~20% of all inherited cases of ALS. Thus, by harnessing an innovative technology for transcriptional engineering that can overcome the limitations of traditional methods for gene silencing, we will develop a new, permanently effective therapy for SOD1-linked familial ALS.

PI_NAMEs: GAJ, THOMAS  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: adeno-associated viral vector;Adverse effects;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Animals;Antisense Oligonucleotides;Astrocytes;Biology;Brain;cell type;Cells;Characteristics;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Data;delivery vehicle;Dependovirus;design;Development;Disease;DNA;DNA Damage;Dose;ds-DNA;effective therapy;Effectiveness;Engineering;Etiology;familial amyotrophic lateral sclerosis;Financial Hardship;Frequencies;gain of function mutation;Gene Delivery;gene editing technology;Gene Expression;Gene Proteins;Gene Silencing;gene therapy;Gene Therapy Agent;Genetic Transcription;genetic variant;genome editor;Genomics;genotoxicity;Goals;immunogenicity;Immunologics;Immunology;improved;in vivo;Inherited;innovative technologies;Interdisciplinary Study;Life Cycle Stages;life time cost;Link;Mediating;Medical;Messenger RNA;Methods;MicroRNAs;minimal risk;Motor Neurons;mouse model;Mus;mutant;Mutation;Nervous System;novel;novel therapeutics;nuclease;off-target mutation;Paralysed;Patients;Performance;pre-clinical;Production;Protein Isoforms;Proteins;Research;Resources;Risk;RNA;RNA Interference;RNA Interference Therapy;RNA Processing;Rodent Model;Role;Safety;Severities;small hairpin RNA;Specificity;Spinal Cord;sporadic amyotrophic lateral sclerosis;superoxide dismutase 1;System;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic effectiveness;therapeutically effective;Time;Toxic effect;Toxicology;transcriptome sequencing;Variant;Viral Vector;Work

PROJECT_TITLE: Development of a CRISPR-Cas13 Gene Therapy for SOD1-Linked ALS


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative  Traumatic brain injury (TBI) is one the leading causes of mortality and morbidity affecting humanity, and a recognized risk factor for late-life neurodegenerative disorders. The absence of validated biomarkers in the neurotrauma field is a barrier to drug development in this area, and there are currently no disease-modifying therapies that limit the burden of TBI. This proposal addresses this gap by aiming to validate serum neurofilament light (NF-L) a biomarker of TAI which can be useful in early-phase clinical trials of therapies aimed at improving axonal resilience and regeneration.

PI_NAMEs: DIAZ-ARRASTIA, RAMON  (contact)

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Address;Affect;Affective;Anisotropy;Area;Atrophic;Axon;axon injury;axonal degeneration;Biological;Biological Assay;Biological Markers;biomarker validation;cerebral atrophy;Clinical;clinical trial participant;Clinical Trials;Cognitive;comorbidity;Complex;Confidence Intervals;Data;Diffusion Magnetic Resonance Imaging;disability burden;Disabling;Disease;drug development;early phase clinical trial;Educational workshop;effective intervention;follow-up;Guidelines;Humanities;Image;Impaired cognition;improved;indexing;individual patient;Injury;injury-related death;Laboratories;late life;Light;Magnetic Resonance Imaging;Maintenance;Measures;Methods;Mitochondria;Molecular;Morbidity - disease rate;mortality;MRI Scans;Natural regeneration;Nerve Degeneration;Nervous System Trauma;Neurodegenerative Disorders;neurofilament;neuroimaging;Neurological outcome;novel therapeutic intervention;Observational Study;Participant;participant enrollment;Pathologic;patient subsets;peripheral blood;pharmacodynamic biomarker;Phase;Population Study;Pre-Clinical Model;precision medicine;Process;Prognostic Marker;promote resilience;Proteins;Receiver Operating Characteristics;Recommendation;Reference Standards;resilience;Risk Factors;Sampling;Scanning;Serum;specific biomarkers;targeted therapy trials;Techniques;Testing;Therapy Clinical Trials;Translations;Traumatic Brain Injury;United States National Institutes of Health;Validation;white matter

PROJECT_TITLE: Clinical Validation of Serum Neurofilament Light as a Biomarker of Traumatic Axonal Injury

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative 16p11.2 copy number variations (CNVs) are highly associated with autism and schizophrenia. In this collaborative study, we will utilize the complementary expertise of two laboratories to model these CNVs in 2- and 3-dimensional cultures of human cortical neurons. We will investigate the development and the metabolomics of excitatory and inhibitory networks as well the molecular and cellular mechanisms underlying the effect of 16p11.2 deletion and duplication on neuronal development and function.

PI_NAMEs: MALETIC-SAVATIC, MIRJANA ;SAHIN, MUSTAFA  (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 16p;16p11.2;3-Dimensional;Address;Affect;Animal Model;Animals;Architecture;autism spectrum disorder;Axon;Behavior;Bioenergetics;Bipolar Disorder;Brain;Brain Diseases;brain volume;Cell Line;Cell membrane;Cell model;Cells;Ceramides;Clinical;clinical phenotype;Coculture Techniques;Code;Complex;connectome;Copy Number Polymorphism;CRISPR/Cas technology;Cytoskeleton;Data;density;Development;dihydroceramide desaturase;Disease;dopaminergic neuron;Energy Metabolism;Engineering;Environment;Enzymes;excitatory neuron;Functional disorder;Gene Expression Profiling;Generations;Genes;Genetic Transcription;genomic locus;Genotype;Glutamates;Homeostasis;Human;human induced pluripotent stem cells;Hyperactivity;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;inhibitory neuron;insight;Intellectual functioning disability;Knowledge;Laboratories;lipid metabolism;lipidome;lipidomics;Lipids;Mass Spectrum Analysis;Mediating;Mental disorders;Metabolic;Metabolism;metabolome;metabolomics;Methodology;Midbrain structure;migration;Mitochondria;Modeling;Molecular;molecular phenotype;Molecular Target;multi-electrode arrays;multimodal data;neurite growth;Neurites;Neurocognitive;Neurodevelopmental Disorder;neuron development;neuronal cell body;neuronal circuitry;Neuronal Differentiation;Neuronal Dysfunction;neuronal excitability;neuronal metabolism;Neurons;new therapeutic target;Organoids;patch clamp;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;Penetrance;Phenotype;pleiotropism;Property;Prosencephalon;protein expression;Regulation;Reporting;Risk Factors;Role;Schizophrenia;Signal Transduction;Sorting;Synapses;synaptic function;synaptogenesis;three-dimensional modeling;Time;tool;Transcript;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;two-dimensional;Variant

PROJECT_TITLE: Effects of 16p11.2 copy number variation on neuronal development and pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MDCN-P(57)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project narrative Caring for an ever aging society represents an increasing social and economical burden and continuing efforts are required to improve health during the course of life. Getting old increases the chances of succumbing to devastating diseases including cancer, and dementias such as Alzheimer’s disease and Parkinson affecting millions of people in the US. These diseases are caused by an increase of damaged and non-functional proteins at old age. We have established an animal model to address the role of decreased pH in the organelles responsible for the degradation of proteins in the fruitfly Drosophila. We are thus in a position to find out how an increase in toxic proteins leads to neurodegeneration in a fly model of Parkinson with the ultimate goal to identify novel treatment options to improve life at old age.

PI_NAMEs: JENNY, ANDREAS  (contact);MACINTOSH, GUSTAVO

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Address;Adipose tissue;Affect;age acceleration;age related;Aging;aging related disease;alpha synuclein;Alzheimer's Disease;amyloid precursor protein processing;Animal Model;apolipoprotein E-4;Autophagocytosis;Blood;Cardiovascular Diseases;Caring;Carrier Proteins;Cells;Cholesterol;Cholesterol Homeostasis;Cytoplasm;Data;Defect;Dementia;Development;Diglycerides;Disease;Drosophila genus;Economic Burden;Endosomes;Environment;Fat Body;Fatty Acids;fly;Functional disorder;Genes;genetic approach;Glycocalyx;Goals;Golgi Apparatus;Health;healthspan;Hemolymph;Homeostasis;Homologous Gene;human model;human old age (65+);Hydrolase;Impairment;improved;insight;Larva;late endosome;Life;Life Cycle Stages;life span;limbic system-associated membrane protein;Link;lipid metabolism;lipid transport;lipidomics;Lipids;Liver;Locomotion;Lysosomal Storage Diseases;Lysosomes;male;Malignant Neoplasms;Membrane;Membrane Proteins;microbiota;Modeling;mosaic analysis;mutant;Mutation;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;Neurons;Neuropathy;novel;Nutritional;Organelles;Paracrine Communication;Parkinson Disease;Pathology;Persons;Phenotype;Positioning Attribute;presenilin-1;Process;protein aggregation;protein biomarkers;protein degradation;Protein Sortings;Proteins;Proteolysis;proteostasis;proteostasis loss;Publishing;Regulation;Research;Risk Factors;Role;sex;Signal Transduction;social;Societies;socioeconomics;Sterols;Structure;System;Testing;Tissues;Toxic effect;transcriptomics;treatment strategy;Vesicle

PROJECT_TITLE: The role of Lamp1 and lipid transport in the regulation of vesicle identity

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking;Women's Health Research

ORG_CITY: BELTSVILLE

ORG_NAME: PACIFIC INSTITUTE FOR RES AND EVALUATION

PHR: PROJECT NARRATIVE The proposed research will provide important information about local policies and programs that can reduce discrimination and alcohol inequities among sexual and gender minorities (SGMs) and SGM subgroups. Identifying local modifiable structural conditions that contribute to SGM health can better inform the development of effective programs and policies to reduce alcohol inequities for SGM populations because (1) local structural conditions may be more immediate and therefore more important for people's day-to-day experiences and (2) local policies might be easier to implement than national or state-wide policies. Also, by understanding how the three levels of stigma operate together to affect alcohol use and problems, results can inform stigma-reduction interventions in healthcare settings and SGM organizations.

PI_NAMEs: LIPPERMAN-KREDA, SHARON  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adult;Affect;Age;Alcohol abuse;Alcohol consumption;alcohol misuse;alcohol related problem;alcohol use disorder;Alcohols;Automobile Driving;Baseline Surveys;Belief;Bisexual;California;cisgender;Cities;Data;demographics;Development;Discrimination;Disease;drinking;drinking behavior;Employee;Environment;Ethnic Population;experience;Exposure to;Feeling;Gays;gender minority;gender minority community;gender minority group;gender minority health;harassment;hazardous drinking;Health;health care settings;health inequalities;Heavy Drinking;Heterosexuals;Human;Human Rights;Individual;Inequality;Inequity;Institution;Intervention;Label;Latinx;Law Enforcement;Laws;Lesbian;Lesbian Gay Bisexual Transgender Queer;Link;Literature;Measures;men;minority stress;Municipalities;Outcome;Participant;perceived discrimination;Personal Satisfaction;Persons;Policies;Population;Prevalence;Process;programs;racial population;reduced alcohol use;Research;Resources;Rights;Role;Services;Sexual and Gender Minorities;sexual minority;sexual minority group;sexual minority men;sexual minority women;Shapes;social;Social Controls;social stigma;Stereotyping;Stigmatization;Subgroup;substance use;Surveys;Symptoms;transgender;United States;Unsafe Sex;Variant;verbal;Violence;Woman;young adult;young adult alcohol use

PROJECT_TITLE: The Role of Local Structural Stigma in Alcohol Related Inequities among SGM Young Adults

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The goal of the proposed work is to substantially enhance the function of electronic retinal implants for treating incurable blindness. We use electrical recordings and stimulation of the isolated macaque and human retina as an experimental lab prototype for this future device, and use it to develop ways to efficiently interface with the neural circuitry of the retina and provide it with high-fidelity artificial visual signals. This research will advance the design of the next generation of retinal implants, to support advanced visual functions such as object recognition and navigation.

PI_NAMEs: CHICHILNISKY, EDUARDO  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Algorithms;Axon;Biophysics;Blindness;Brain;Calibration;Cells;clinically relevant;Code;Collection;Complex;Computing Methodologies;density;design;Development;Devices;Electric Stimulation;Electrodes;Electronics;Future;Goals;Human;Image;Implant;implant design;improved;Individual;laboratory experiment;Macaca;Modeling;multi-electrode arrays;neural;neural circuit;next generation;novel;object recognition;Patients;Pattern;Persons;Population;predictive modeling;prototype;Research;Resolution;Retina;retina implantation;Retinal Degeneration;Retinal Ganglion Cells;retinal stimulation;sight restoration;Signal Transduction;Site;spatiotemporal;Stimulus;Techniques;Testing;Translations;Triplet Multiple Birth;Vision;Visual;visual coding;Visual Perception;Work

PROJECT_TITLE: Adaptive high-resolution electrical stimulation for retinal implant design

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ORG_NAME: TUFTS MEDICAL CENTER

PHR: Public Health Statement Our objective is to develop tools that improve early diagnosis of systemic light-chain (AL) amyloidosis, a disease that causes heart and kidney failure and early death, in patients with smoldering multiple myeloma, a disease in which patients make immunoglobulin free light chains but are relatively asymptomatic. By studying patients with smoldering myeloma and analyzing their light chain levels, the genes in their myeloma cells and a certain heart-related protein we will be able to establish the likelihood that they have or will get AL.

PI_NAMEs: COMENZO, RAYMOND LUKE (contact)

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Address;advanced disease;Age;Algorithms;Amyloid;Amyloidosis;Attention;base;Biological Assay;Biological Markers;Biology;biomarker identification;Biopsy;Blood;Blood specimen;Boston;Brain;Cardiac;Caring;Cells;Certification;Cessation of life;Chromosome abnormality;Clinical;Clinical Laboratory Improvement Amendments;Congo Red;Cyclin D1;Cytogenetics;Data;Data Collection;Databases;Death Rate;Decision Making;Dependence;Deposition;design;design verification;Diagnosis;Disease;Disparity;Early Diagnosis;Early Intervention;Enrollment;Failure;Future;Genes;Germ Lines;Goals;Heart;Heart failure;Hepatic;Immunoglobulin Variable Region;Immunoglobulins;improved;Investigation;kappa opioid receptors;Kidney;Kidney Failure;Knowledge;Laboratories;Light;Marrow;member;Modeling;Molecular Biology;Monoclonal Gammapathies;mortality;Multiple Myeloma;N-terminal;next generation;next generation sequencing;novel marker;overexpression;participant enrollment;Pathologic;Patient Care;patient screening;Patients;Peripheral Nervous System Diseases;Phase;Plasma Cells;Population;precision medicine;primary amyloidosis of light chain type;Process;prohormone;prospective;Proteins;Provider;Public Health;Regulation;Research Personnel;Retrospective Studies;Risk;Risk Assessment;Role;saluretic;screening;Series;Site;Specimen;Stains;standard of care;Statistical Algorithm;Statistical Models;statistics;sulfated glycoprotein 2;Support Groups;Symptoms;Systemic Therapy;Techniques;Testing;tool;Training;training data;Universities;Validation;validation studies;Work

PROJECT_TITLE: Screening for AL Amyloidosis in Smoldering Multiple Myeloma

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Sleep Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Mental fatigue—a feeling of exhaustion often accompanied by the sense that every task requires great effort—is prevalent in many neurological and psychiatric diseases. In healthy subjects, it is a common symptom ensuing after extended wake or intense learning. However, the reasons why we become mentally tired remain unknown. Based on recent findings, we hypothesize that a key mechanism underlying mental fatigue after sleep deprivation or intense learning is the increasing occurrence of brief, local periods of silence of brain cells. These “OFF periods” normally occur throughout the brain during sleep, but they can occur locally in wake (“local sleep” in wake) when we stay up for too long or engage in intense tasks. This project is relevant to public health because it will provide a mechanistic explanation of mental fatigue and its negative consequences. If successful, the proposed experiments will identify 1) a specific circuit of inhibitory and excitatory cortical neurons responsible for mental fatigue after extended wake or intense learning; 2) a neural mechanism underlying mental fatigue—the active induction of periods of silence in cortical neurons during wake. This project will also result in a large dataset of electrophysiological recordings from multiple areas of the brain. This dataset can be used in future studies to test whether, due to inflammatory or neuromodulatory changes, the neural circuit responsible for mental fatigue after extended wake or intense learning is also involved in pathological fatigue.

PI_NAMEs: CIRELLI, CHIARA  (contact);TONONI, GIULIO

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Acute;Affect;Agonist;Animals;Area;Attention;Autoimmune Diseases;awake;Axon;Behavior;behavior measurement;Behavioral;Brain;brain cell;brain dysfunction;cell type;Cells;Chronic;common symptom;Complex;Corpus striatum structure;Coupled;D Cells;Data;Data Set;density;Disease;Drowsiness;Electroencephalography;Electrophysiology (science);Empathy;Event;exhaustion;experimental study;Fatigue;Feeling;Funding;Future;Generations;Genetic;genetic manipulation;Glutamates;Goals;Head;hippocampal pyramidal neuron;Hippocampus;Hour;Human;Impaired cognition;Impairment;improvement on sleep;in vivo;in vivo evaluation;Inflammatory;Injections;large datasets;Lead;Learning;Link;Malignant Neoplasms;Mediating;member;Memory;Mental disorders;Mental Fatigue;Modeling;Motivation;motor learning;Multiple Sclerosis;Mus;Nervous System Disorder;neural circuit;neuromechanism;neuronal excitability;Neurons;neuroregulation;non rapid eye movement;novel;optogenetics;Parkinson Disease;Pathologic;Performance;pharmacologic;predictive modeling;presynaptic;prevent;Psyche structure;Public Health;Pyramidal Cells;Rattus;receptor;recruit;Rest;Risk;Rodent;Rodent Model;Role;Sampling;Sleep;Sleep Deprivation;Sleep Disorders;sleep quality;Slow-Wave Sleep;Somatostatin;Stroke;Structure;Study models;Symptoms;Synapses;Testing;Thalamic structure;Time;United States National Institutes of Health;willingness;Work

PROJECT_TITLE: Local sleep and mental fatigue

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The goal of this project is to characterize an emerging tumor suppressor ATF3 for its roles in regulating cells’ ability to repair DNA damage. Successful completion of the proposed research will culminate in a better understanding of how cells defend themselves from DNA damage and malignant transformation, and ultimately lead to the development of novel anti-cancer therapies. This study will also have a potential to identify biomarkers for predicting patient responses to radiation therapy and thus lead to improved treatment outcomes that would benefit millions of people suffering from cancer.

PI_NAMEs: YAN, CHUNHONG  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Acetylation;activating transcription factor 3;Address;anti-cancer;ataxia telangiectasia mutated protein;Binding;biomarker identification;cancer cell;cancer therapy;Cell Physiology;Cells;chemotherapeutic agent;chemotherapy;Chemotherapy and/or radiation;Chromatin;Chromatin Structure;Data;Development;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;Double Strand Break Repair;EP300 gene;Event;Evolution;Excision;gamma irradiation;Gamma-H2AX;Genes;Genetic Transcription;Genetically Engineered Mouse;Genome;genome integrity;Genome Stability;genotoxicity;Goals;Hematopoietic;Hematopoietic stem cells;Histone Acetylation;histone acetyltransferase;Histone H3;Histones;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;Impairment;improved;Knockout Mice;Lead;Lymphomagenesis;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;Modeling;mouse model;Mus;Nonhomologous DNA End Joining;novel;novel strategies;Nucleosomes;Outcome;p53-binding protein 1;Pathway interactions;patient response;Persons;Physiological;Play;predictive marker;prevent;Proteins;Publishing;Radiation;radiation response;Radiation therapy;Reader;recruit;Regulation;Relaxation;repaired;Research;response;Role;sensor;Site;Stress;Testing;TP53 gene;Treatment outcome;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Ubiquitination

PROJECT_TITLE: ATF3 Regulation of Histone Acetylation in Genome Maintenance

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: WASHINGTON

ORG_NAME: CARNEGIE INSTITUTION OF WASHINGTON, D.C.

ORG_STATE: DC

PI_NAMEs: MC FALL-NGAI, MARGARET J (contact);RUBY, EDWARD G

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Animals;Apical;Bacteria;Bacterial Model;Biochemical;Biological Models;Biology;Birth;CCRL2 gene;Cells;Chronic;Communities;Complex;Confocal Microscopy;critical period;Epithelium;Euprymna scolopes;Event;Fostering;frontier;Generations;Genetic Transcription;Genomics;Goals;Gram-Negative Bacteria;Health;host-microbe interactions;Hour;Human;Human Microbiome;human tissue;Image;infancy;innovation;insight;Instruction;Libraries;Light;Microbe;Microbial Genetics;microbiota;Modeling;Molecular;Mucous Membrane;nano-string;new technology;normal microbiota;Outcome;Pathogenesis;pathogenic microbe;Pathogenicity;Process;programs;Research;Resolution;RNA;Squid;Surface;symbiont;Symbiosis;System;Tissues;Transcript;transcriptome sequencing;transcriptomics;V. fischeri-squid system;Vibrio;Vibrio fischeri;Visualization

PROJECT_TITLE: Vibrio fischeri as a Model for Bacterial Colonization

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: NARRATIVE Boston University School of Medicine has designed a Post-baccalaureate research education program that will provide research experiences and professional skills development for underrepresented minorities with the primary goal of these scholars becoming competitive applicants for graduate training programs. The long term goal of this BU PREP program is to enhance diversity in biomedical research and facilitate the discussion and awareness of inclusiveness and tolerance at BUSM.

PI_NAMEs: HENDERSON, ANDREW J (contact);SCHON, KARIN

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Academic support;Address;Admission activity;Awareness;Biomedical Research;Boston;Calendar;career;Career Choice;career development;Communication;Communities;Consultations;Credentialing;Critical Thinking;demographics;design;Development;disabled students;disadvantaged student;Doctor of Philosophy;education research;Educational workshop;effectiveness evaluation;Environment;experience;Faculty;falls;Goals;graduate school;Grant;improved;Individual;Infrastructure;Institution;Interdisciplinary Study;Interview;Journals;Laboratories;laboratory experience;Leadership;Learning;Manuscripts;Medical;medical schools;meetings;Mentors;Outcome;outreach program;Participant;Performance;Population;Postbaccalaureate;Program Development;Program Evaluation;programs;Qualifying;Records;recruit;Research;Resources;satisfaction;Scholars Program;Science;Self Assessment;skill acquisition;skills;Student recruitment;Students;success;summer research;Techniques;Training;Training Programs;trait;tutoring;Underrepresented Minority;underrepresented minority student;Underrepresented Students;Universities;Work;Work Ethic;Writing

PROJECT_TITLE: BU PREP

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative  Synthetic organic chemistry is a rate-determining factor in the production and discovery of small-molecule pharmaceuticals; thus, continued innovation in synthetic methodology is of vital importance for developing the next generation of medicines for improved human health. The aim of this proposed research is to synthesize and characterize novel late-transition-metal-oxo complexes and harness their reactivity for the selective catalytic oxidation of sterically unhindered methyl groups on complex molecules. The results of these studies are expected provide a valuable tool for synthetic chemists to prepare and derivatize complex bioactive molecules for drug discovery efforts and validate the utility of late-transition-metal-oxo complexes for the oxidation of strong C–H bonds.

PI_NAMEs: BOIT, TIMOTHY BARTLETT (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Acceleration;Alcohols;analog;Architecture;Area;Attention;Binding;carbene;Carbon;catalyst;chemical property;chemical synthesis;Chemicals;comparative;Complex;Coupling;Derivation procedure;Development;Disparity;drug discovery;Drug Industry;electronic structure;Electronics;forging;functional group;Health;Human;Hydrogen Bonding;hydroxyl group;improved;In Situ;Industry;innovation;insight;Kinetics;Ligands;Medicine;Metals;Methodology;Methods;methyl group;Natural Products;next generation;nitrene;novel;Organic Chemistry;Organometallic Compounds;oxene;Oxidants;oxidation;Oxygen;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Physical condensation;Preparation;prevent;Production;Reaction;Research;Role;Route;scaffold;Series;Site;small molecule;Structure;Structure-Activity Relationship;Synthesis Chemistry;Technology;tool;Transition Elements;trend

PROJECT_TITLE: Selective Oxidation of Primary C-H Bonds Using Late-Transition-Metal-Oxo Catalysts


NIH_SPENDING_CATS: Lung;Microbiome;Nutrition

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative This study focuses on uncovering new biology underlying the gut-lung immune axis, which has been shown to regulate specific inflammatory processes in the lung. We will systematically study gut microbiome-derived factors that directly influence lung immunity, lung cells that integrate these signals, as well as explore the molecular basis for manipulating or disrupting the gut-lung axis in health and disease.

PI_NAMEs: PRAKASH BUDDE, ARUN  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: absorption;Acceleration;Acute;Adopted;Affect;Alveolar;Alveolar Cell;Alveolar Macrophages;Antibiotic Therapy;Antibiotics;Arthritis;Asthma;Biology;Cell Reprogramming;cell type;Cells;Circulation;Clinical;Communication;Critical Illness;Data;design;Development;Diet;dietary;Dietary Supplementation;Disease;dysbiosis;experience;experimental study;Extrinsic asthma;Feces;Future;Gastrointestinal tract structure;Goals;gut bacteria;gut microbiome;gut microbiota;gut-lung axis;Health;hospital care;Hospitalization;Host Defense;Human;Immune;Immune response;Immunity;Immunobiology;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;insight;Interleukin-1 beta;Intervention;Intestines;Knowledge;Ligands;Link;Lipopolysaccharides;Lung;Lung immune response;Lung infections;lung ischemia;Mechanical ventilation;Mediating;Metabolic;Metabolic Pathway;metabolomics;microbial;microbiome;microbiome therapeutics;microbiota;migration;Modeling;Molecular;Mus;Natural Immunity;neutrophil;Nonesterified Fatty Acids;novel therapeutics;Organ;Outcome;Parenteral Nutrition;Patients;Pattern;preservation;Process;Production;programs;Proteins;pulmonary function;Pulmonary Inflammation;receptor;Receptor Signaling;Reperfusion Injury;Research;Resources;restoration;Role;Signal Pathway;Signal Transduction;Sterility;Structure of parenchyma of lung;supplemental oxygen;Supplementation;System;Therapeutic;Therapeutic Intervention;therapy development;Tissues;Toll-like receptors;transmission process;Trauma;Travel;Up-Regulation;vascular bed;Volatile Fatty Acids

PROJECT_TITLE: The Gut-Lung Axis: Immunometabolism Linking the Gut Microbiome and Lung Imunity

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Bioengineering;Digestive Diseases;Liver Disease;Natural Products;Rare Diseases;Rehabilitation

PHR: Project Narrative This program targets a new approach for treating currently incurable human diseases caused by missing enzyme functions, and automated lego-like platforms for making lipids and polycyclic terpenoids – two classes of natural products that perform a broad range of functions important to human health but remain challenging to prepare in the laboratory. Collectively, these efforts stand to substantially expand the potential for naturally occurring small molecules and their derivatives to advance human health.

PI_NAMEs: BURKE, MARTIN D (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Animals;Area;Argininosuccinate lyase deficiency;Biochemical Reaction;Biological;Biology;Blood;capsule;Chemicals;Chemistry;Complex;Cyclization;Development;Disease;enzyme deficiency;Enzymes;flexibility;frontier;Health;Human;human disease;Industrialization;Ion Channel;Laboratories;Link;Lipids;Medicine;Methods;mimicry;Molecular;molecular scale;mouse model;Natural Products;novel strategies;Organic Synthesis;Organism;Ornithine carbamoyltransferase deficiency;Persons;Physiology;Plasma;Polyunsaturated Fatty Acids;Predisposition;Preparation;Process;programs;Prosthesis;Protein Deficiency;Reagent;Research;restoration;self assembly;small molecule;Structure;Terpenes;Tissues;Tyrosinemias

PROJECT_TITLE: Molecular Prosthetics and Lego Chemistry

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: JACKSON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Overall-Narrative The health-disease continuum is a process through various states of health and disease (such as heart disease, diabetes, cancer, and Alzheimer’s) and can fluctuate throughout life. While chronic diseases can be treated, an understanding of genetic susceptibility and molecular mechanisms involved in disease onset has the potential to halt progression and return an individual to a healthy state. The proposed Molecular Center of Health and Disease, through a Phase I COBRE, seeks to apply innovative molecular technology and computational biology to enhance research, discovery, and innovation in understanding the health-disease continuum and lead to better interventions to improve health.

PI_NAMEs: GARRETT, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Academy;Address;Alzheimer's Disease;Big Data Methods;Biological;Biology;career;career development;Cause of Death;Centers of Research Excellence;Cessation of life;Chronic;Chronic Disease;Clinical;Collaborations;Computational Biology;Core Facility;cost;CRISPR/Cas technology;Data;data integration;Data Set;Development;Diabetes Mellitus;diet and exercise;Discipline;Disease;Disease Progression;Early Intervention;economic indicator;Education;Eligibility Determination;Environment;Funding;gene editing technology;gene function;Genetic;Genetic Predisposition to Disease;Genome;Genomics;Goals;Health;Healthcare;Heart Diseases;improved;Individual;individualized medicine;Influenza;Infrastructure;innovation;insight;Instruction;Interdisciplinary Study;Intervention;Kidney Diseases;Life;Malignant Neoplasms;Medical;Medical center;Mentors;Mentorship;metabolomics;Methodology;Methods;Mission;Mississippi;Molecular;novel;Onset of illness;Organ;pathogen;Pathway interactions;Peptide Initiation Factors;Persons;Phase;Physiological;Physiology;Pilot Projects;Population;Privatization;Process;Productivity;programs;Proteomics;Qualifying;Research;Research Infrastructure;Research Personnel;Research Support;Research Training;Sepsis;single-cell RNA sequencing;statistics;Stroke;synergism;Technology;Therapeutic Intervention;therapeutically effective;Training;transcriptomics;translational approach;United States;Universities;Whole Organism;Work

PROJECT_TITLE: Molecular Center of Health and Disease


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Address;Advisory Committees;Area;Bioinformatics;Biometry;career;Cause of Death;Centers of Research Excellence;Charge;Chronic Disease;Collaborations;Complement;Computational Biology;Core Facility;Creativeness;Data Set;Diabetes Mellitus;diet and exercise;Disease;Disease Progression;Early Intervention;early-career faculty;Education;Ensure;Environment;Evaluation;Extramural Activities;Faculty;Feedback;Fostering;Funding;Genes;Genetic Predisposition to Disease;Genomics;Goals;Grant;Health;Heart Diseases;improved;Individual;individualized medicine;Infrastructure;innovation;insight;Institution;Investigation;Kidney Diseases;Leadership;lipidomics;Medical;Medical center;meetings;member;Mentors;Mentorship;metabolomics;Methodology;Mission;Mississippi;Molecular;multidisciplinary;National Institute of General Medical Sciences;new technology;novel;Onset of illness;Organism;pathogen;Phase;Physiological;Physiology;Pilot Projects;Policies;Population;Program Development;programs;Proteomics;recruit;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Research Training;Socioeconomic Status;Stroke;Structure;Systems Biology;Teacher Professional Development;Technology;Training;transcriptomics;United States;Universities;Whole Organism;Work

PROJECT_TITLE: Core A- Administration, Education, and Mentoring


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PROJECT_TERMS: Address;Bioinformatics;Biological;Biological Assay;Biological Process;Biometry;Biostatistics Core;Body System;Cell Line;cell type;Cells;Complement;Computational Biology;Consultations;CRISPR/Cas technology;Data;Data Collection;Data Set;Development;Disease;Disease Progression;Early Intervention;Education;education planning;Enhancement Technology;Ensure;enzyme activity;Epigenetic Process;epigenetic regulation;Equipment;expectation;Extramural Activities;Faculty;Faculty Workshop;Funding;gene editing technology;Gene Expression;gene function;gene-editing approach;Generations;Genes;Genetic Predisposition to Disease;Genetic Variation;Genome;genome sequencing;genome-wide;Genomics;Genotype;Goals;Health;high throughput technology;High-Throughput Nucleotide Sequencing;Human Resources;improved;Infrastructure;innovation;insight;Instruction;instrumentation;Investigation;Link;Lipids;loss of function;Maintenance;Mass Spectrum Analysis;Measures;meetings;Mentors;Mentorship;metabolomics;Metagenomics;Methodology;Methods;Methylation;Mission;Molecular;new technology;new therapeutic target;next generation sequencing;novel;Organ;Pathway interactions;Pharmaceutical Preparations;Phase;Physiological;Physiology;Pilot Projects;Process;Program Description;programs;Proteins;Proteomics;Research;Research Personnel;Resources;service delivery;Services;small molecule;Students;success;Supervision;synergism;Systems Biology;Teacher Professional Development;Technical Expertise;Techniques;Technology;Therapeutic;Tissues;Toxin;Training;Training and Education;training opportunity;Transcript;transcriptome sequencing;transcriptomics;Variant;viral vector development;whole genome;Work;Xenobiotics

PROJECT_TITLE: Core B-Omics and Gene-Editing