NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: NAAR, SYLVIE  (contact)

PROJECT_TERMS: Academia;Address;career;career development;Chronic Disease;cohort;Communication;Communities;Community of Practice;conflict resolution;design;Development;Development Plans;Disease Management;disorder prevention;diversity and inclusion;early-career faculty;Educational workshop;Ensure;Equity;equity, diversity, and inclusion;evidence base;experience;Faculty;faculty research;field study;Florida;Fostering;Funding;Goals;Growth;Health;health science research;Health Sciences;health training;Human Resources;improved;Individual;Institution;Institutional Practice;Knowledge;Learning;meetings;member;Mental Health;Mentors;Modeling;next generation;Organizational Change;pre-doctoral;Process;Productivity;Professional Organizations;programs;prospectuses;Public Health;racism;Research;research and development;Research Personnel;resilience;Resources;Science;Scientist;Series;Sexism;skills;social;Social Environment;supportive environment;symposium;System;Teacher Professional Development;Testing;Textiles;United States National Institutes of Health;Universities;Work;Workforce Development;Writing


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: OVERVIEW: PROJECT NARRATIVE Despite a strong evidence base for diabetes prevention and care, significant gaps remain in equitably translating these research findings into real life policy and practice; the overall burdens and costs continue to grow rapidly, with the minorities and socioeconomically disadvantaged groups in the Southeastern U.S. disproportionately affected. To address these gaps, we propose the Georgia Center for Diabetes Translation Research (GCDTR) with the vision of promoting equity through high-quality translation research and a culture of evidence based decision-making across academic, health system, community, and local government partners in Georgia, Florida, and Tennessee. GCDTR will serve as a platform to increase investigator capacity, share expertise, and generate and disseminate knowledge to influence practice and policy to improve diabetes outcomes and health equity.

PI_NAMEs: NARAYAN, KABAYAM M VENKAT (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adoption;Affect;Award;base;Behavior;Behavioral;Behavioral Sciences;Businesses;Cardiovascular Diseases;career;Caring;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Sciences;cohesion;Collaborations;Communities;community engaged research;community setting;comorbidity;cost;Country;COVID-19;Data;Decision Making;design;diabetes management;Diabetes Mellitus;Diabetes prevention;diabetes risk;Discipline of Nursing;Disparity population;economic cost;economic disparity;Economically Deprived Population;Economics;Effectiveness;Emerging Technologies;Engineering;Equity;ethnic disparity;Ethnic Origin;Ethnic Population;Evaluation;evidence base;experience;Faculty;Failure;Florida;Funding;Future;Geography;Government;Grant;Health;health disparity;health disparity populations;health equity;health equity promotion;Health equity research;Health Promotion;Health Sciences;Health system;high risk;HIV;Home;improved;innovation;Institution;Intervention;K-Series Research Career Programs;Knowledge;knowledge translation;Leadership;Learning;Life;Local Government;Maintenance;Measurement;medical schools;Medicine;member;Mental Depression;Metabolic;Methodology;Minority;Modeling;Morehouse School of Medicine;multidisciplinary;next generation;older adult;Outcome;pharmacologic;Policies;Population Heterogeneity;Postdoctoral Fellow;prevent;Prevention;programs;Public Health Schools;racial minority;racial minority population;recruit;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Rural;School Nursing;Schools;Science;Services;social;social disparities;socioeconomic disadvantage;socioeconomics;Sorting;Subgroup;success;Talents;Technology;Tennessee;Translating;translational health science;Translational Research;translational scientist;Translations;underserved area;Underserved Population;United States National Institutes of Health;Universities;Vision;Vulnerable Populations;Work


NIH_SPENDING_CATS: Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Adherence;Advisory Committees;Award;base;Caring;cohesion;Collaborations;Committee Members;Communication;Communities;Consultations;Creativeness;Data;Dedications;Department chair;Diabetes Mellitus;Diabetes prevention;Disparity;disparity reduction;effectiveness research;Electronics;Ensure;Equity;Evaluation;experience;Faculty;Feedback;Financial Support;Funding;Goals;Grant;Growth;health equity;health equity promotion;Human Resources;improved;Infrastructure;Institution;Leadership;Link;Marketing;meetings;member;Mentors;Mission;Monitor;Morehouse School of Medicine;National Institute of Diabetes and Digestive and Kidney Diseases;Newsletter;Outcome;Outreach Research;peer coaching;Policies;Process;Productivity;programs;recruit;Reporting;Research;Research Activity;research faculty;Research Personnel;Research Support;Resources;Role;Services;Shapes;Strategic Planning;Structure;Training Activity;Translational Research;translational research program;translational scientist;Translations;United States National Institutes of Health;Universities;Update;Vision;web site

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE – Overall This renewal application seeks to continue support for the Georgia Cystic Fibrosis Research and Translation Core Center (the Georgia CF Core Center) at Emory University, Children's Healthcare of Atlanta, Augusta University, and the Georgia Institute of Technology. The Center leverages activities at these institutions to solve critical problems associated with CF, specifically those within the mission of the NIDDK. Three biomedical research Cores, an Administrative/Enrichment Core, and a Pilot & Feasibility Program are included.

PI_NAMEs: MCCARTY, NAEL A (contact);STECENKO, ARLENE A

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Address;Aging;base;Basic Science;Behavior;Behavioral;Biomedical Engineering;Biomedical Research;biomedical scientist;Bone Diseases;Budgets;Center Core Grants;Child;Child health care;Clinical;Clinical Informatics;Clinical Research;Collaborations;Communities;comorbidity;Cystic Fibrosis;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Data;data integration;data warehouse;Development;Diabetes Mellitus;Diet;Direct Costs;Disease;Disease Progression;Endocrinology;Ensure;Environment;Exercise;Extramural Activities;Functional disorder;Funding;gastrointestinal;glucose metabolism;Goals;Health;health equity;Hepatology;Homeostasis;Informatics;innovation;Institution;Knowledge;Life Style;Link;Liver diseases;Longevity;Longitudinal Studies;Lung;member;Metabolic;Mission;Molecular;mutant;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;novel;novel therapeutic intervention;nutrition;Nutritional;Nutritional status;Outcome;pandemic disease;Patients;Persons;Phenotype;Population;preventive intervention;programs;Ramp;Research;Research Personnel;Research Project Grants;Research Support;Resources;Science;Scientist;Sleep;small molecule therapeutics;success;Technology;Therapeutic;Toddler;translational potential;Translations;Universities


ADMINISTERING_IC: MH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE Neuroligins are specialized neural cell adhesion molecules that are found in synapses, the functional interfaces between neurons in the brain. Mutations in these proteins and their binding partners cause neuropsychiatric diseases, including autism spectrum disorders and schizophrenia. Here, we propose to investigate the how Neuroligins regulate synaptic function in mice and human neurons.

PI_NAMEs: SUDHOF, THOMAS C.;WERNIG, MARIUS  (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Adhesions;Affinity;Alleles;Astrocytes;autism spectrum disorder;Behavior;behavior test;Binding;Biochemical;Biological Assay;Biophysics;Brain;Cell Adhesion Molecules;Cell Line;cell type;Cells;Coculture Techniques;Code;Compensation;Complement;Complex;conditional mutant;Cre driver;Cultured Cells;Disease;Electrophysiology (science);Exhibits;experimental study;Family;Family member;family structure;Foundations;Functional disorder;Funding;Gene Expression;Gene Family;gene function;Generations;Genes;Genetic;Goals;Hippocampus;Human;human disease;human stem cells;Immunoprecipitation;Induced Neurons;insight;Knock-out;Knockout Mice;Link;loss of function;Maintenance;male;Maps;Mediating;Molecular;Morphology;mouse model;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutate;Mutation;Neural Cell Adhesion Molecules;neural circuit;Neurodevelopmental Disorder;Neuroglia;neuronal circuitry;Neurons;neuropsychiatric disorder;novel;oligodendrocyte progenitor;Pattern;Phenotype;Point Mutation;postsynaptic;precursor cell;Preparation;presynaptic;Property;Proteins;Regulation;Role;Schizophrenia;Specific qualifier value;Specificity;subcellular targeting;Synapses;synaptic function;Synaptic Transmission;synaptogenesis;System;Testing;tool;Variant;Work;X Chromosome;Y Chromosome

PROJECT_TITLE: Induced neuronal cells: A novel tool to study neuropsychiatric diseases


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PI_NAMEs: BARILE, JOHN PAUL (contact)

PROJECT_TERMS: Address;archived data;career;career development;cohort;Collaborations;Communication;Communities;Coordination and Collaboration;Data;Data Reporting;diversity and inclusion;effectiveness evaluation;Elements;equity, diversity, and inclusion;Evaluation;Faculty;Feedback;Florida;Focus Groups;Fostering;Funding;Goals;Growth;Hawaii;Health Sciences;Human Resources;implementation evaluation;improved;Individual;Infrastructure;innovation;Institution;Interview;Knowledge;Laboratories;Leadership;Logic;meetings;member;Mentors;Methods;model design;Modeling;Monitor;Outcome;Outcome and Process Assessment;Participant;Process;Productivity;Program Evaluation;programs;Recommendation;Records;recruit;Reporting;Research;research and development;Resources;Science;System;Systems Theory;Teacher Professional Development;Techniques;timeline;Training;Universities

PROJECT_TITLE: Fostering Institutional Resources for Science Transformation: The FLORIDA-FIRST Health-science Brigade

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-Y]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infant Mortality;Lung;Neonatal Respiratory Distress;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Telehealth

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Teleneonatology is an innovative program that uses real-time audio-video telemedicine to connect doctors with expertise in newborn resuscitation with teams caring for at-risk babies born in small, community hospitals. The proposed research is relevant to public health because it will contribute new knowledge about the impact teleneonatology has on early newborn death and disability, and the quality of delivery room care – which are relevant, important patient and family measures for the 10,000-15,000 at-risk newborns each year who experience poorer outcomes because of the current problem. Thus, the project is relevant to the NICHD mission to enhance the lives of newborns and optimize abilities for all, while also addressing the cross-cutting topic of health disparities.

PI_NAMEs: DEMAERSCHALK, BART M;FANG, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Address;Birth;Birth Weight;Brain imaging;Brain Injuries;Breathing;Cardiopulmonary Resuscitation;care delivery;Caring;Cessation of life;Chest;Clinical Trials;Community Hospitals;Consult;Continuous Positive Airway Pressure;Critical Illness;Data;Delivery Rooms;design;Development;disability;Distant;Effectiveness;Electroencephalography;Eligibility Determination;Emergency Situation;Epinephrine;Equity;evidence base;experience;Family;fetal;Future;Goals;Health;health care delivery;health disparity;Health Services Accessibility;hospital care;Hospitals;improved;improved outcome;Inequity;innovation;Intervention;Intervention Studies;intraventricular hemorrhage;Knowledge;Life;Location;Measures;Mission;Modeling;Morbidity - disease rate;mortality;mortality risk;Multicenter Trials;National Institute of Child Health and Human Development;natural hypothermia;neonatal care;neonatal health;Neonatal Intensive Care Units;neonatal morbidity;Neonatal Mortality;neonatal resuscitation;neonate;Newborn Infant;Outcome;outcome disparities;Oxygen;Patients;Pilot Projects;Pneumothorax;poor health outcome;Population;premature;pressure;programs;prospective;Public Health;Randomized;Readiness;Research;Resuscitation;Risk;Risk Reduction;routine care;Seizures;Service delivery model;Site;Telemedicine;Telephone;Testing;Therapeutic;Time;ventilation;Very Low Birth Weight Infant;Visualization

PROJECT_TITLE: The TELENEO Trial: A Multicenter Trial of Telemedicine for Advanced Neonatal Resuscitations in Community Hospitals

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative Visual experience during the critical period is crucial for the proper development and wiring of the visual cortex. The goal of this proposal is to elucidate how astrocytes -- a glial cell type that acts as a regulator of neuronal homeostasis, physiology, and plasticity-- regulate the visual critical period. This has important implications for identifying key therapeutic targets to create an environment favorable to remodeling and plasticity after synapse loss.

PI_NAMEs: SANCHO FERNANDEZ, LAURA  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Adolescence;Adult;Age;Astrocytes;Binding;Biological;Biological Assay;Brain;Calcium;Candidate Disease Gene;cell type;Cellular Membrane;comparison control;Contralateral;critical developmental period;critical period;cyr61 protein;Data;Dendrites;Development;differential expression;Electrophysiology (science);Environment;Excision;experience;experimental group;experimental study;Extracellular Matrix;Eye;Faculty;Feedback;functional plasticity;Future;gene induction;Genes;Genetic Recombination;Goals;Heparan Sulfate Proteoglycan;Homeostasis;Image;Immediate-Early Genes;Immunoprecipitation;in vivo imaging;inducible Cre;Integrins;Investigation;Knock-out;Knockout Mice;Laboratories;LDL-Receptor Related Protein 1;Lead;liquid chromatography mass spectroscopy;Low Density Lipoprotein Receptor;LoxP-flanked allele;magnetic beads;Maps;Mass Spectrum Analysis;Measures;meetings;member;monocular;monocular deprivation;mRNA Expression;Mus;Nervous System Disorder;neural;neural circuit;Neuroglia;neuron component;Neuronal Plasticity;Neurons;novel;Ocular Dominance;Organ;overexpression;Paper;Peer Review;permissiveness;Physiology;Play;Postdoctoral Fellow;Protein Secretion;Proteins;Publishing;receptor;repaired;Reporting;Research;Research Personnel;Research Proposals;response;Role;Sampling;Series;Stereotyping;Structure;Synapses;synaptogenesis;Tamoxifen;therapeutic target;Training;Transgenic Mice;Vertebral column;Virus;Visual;Visual Cortex;Work;Writing

PROJECT_TITLE: The role of astrocytes in visual critical period plasticity


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PI_NAMEs: ALI, MOHAMMED KUMAIL (contact)

PROJECT_TERMS: Address;Applications Grants;Blood Vessels;burden of illness;Cardiology;care costs;Caring;catalyst;Clinical;Clinical Medicine;Collaborations;Communities;comorbidity;comparative effectiveness;Complement;Consultations;cost effective;cost effectiveness;Data;Data Analytics;Data Set;Databases;Decision Making;design;Detection;diabetes management;Diabetes Mellitus;Diabetes prevention;diabetes risk;Diagnosis;Discipline of Nursing;disparity elimination;disparity gap;Disparity population;Dissemination and Implementation;Economics;Effectiveness;Endocrinology;Engineering;Epidemiology;Equity;Ethics;Evaluation;Event;Evidence based intervention;experience;Familiarity;Federal Government;Funding;gaps in access;geographic disparity;Geographic Locations;Geriatrics;Goals;Grant;Guidelines;Health;health care service utilization;Health Disparities Research;health disparity;health equity;health record;Health Services;Health Services Research;Health system;Healthcare;implementation efforts;implementation framework;implementation science;improved;improved outcome;Incidence;Infrastructure;innovation;Institution;Internships;Intervention;Investments;Journals;K-Series Research Career Programs;learning progression;Life;Link;Local Government;Manuscripts;Medicine;Mentors;Metabolic;Methodology;Methods;Minority;minority investigator;Morbidity - disease rate;multi-component intervention;multidisciplinary;Outcome;Pathway interactions;patient oriented;personalized approach;Persons;Pilot Projects;Play;Policies;Policy Research;Population;population based;Population Heterogeneity;Populations at Risk;pragmatic trial;prevent;Prevention;Prevention program;Preventive;Preventive service;Primary Care;Procedures;programs;provider behavior;Publishing;Quality of Care;Recommendation;Reporting;Research;Research Design;Research Personnel;Resources;Role;Science;Services;Severity of illness;social determinants;statistics;Structure;Students;success;Surveys;symposium;System;Target Populations;tool;training opportunity;Translating;translational potential;Translational Research;translational scientist;Translations;Underrepresented Minority;Universities;uptake;Variant

PROJECT_TITLE: Design and Evaluation for Equity Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE This proposal focuses on elucidating the genetic determinants and mechanisms underlying immune checkpoint blockade therapy efficacy and resistance. We propose to use a combination of systematic large-scale genomics, preclinical animal modeling, integrated immunogenomics profiling, and mechanism-directed immunologic analyses to establish a robust understanding of sensitivity and resistance to immune checkpoint blockade. Our studies will build the foundation for the precise and individual application on immunotherapy for cancer patients.

PI_NAMEs: CHAN, TIMOTHY AN-THY (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Address;Affect;Animal Model;anti-CTLA4;anti-PD-1;Antibodies;cancer immunotherapy;Cancer Patient;Credentialing;CTLA4 gene;design;DNA Repair;driver mutation;Foundations;Genetic;Genetic Determinism;Genomics;Genotype;Germ Lines;Goals;Immune;immune checkpoint blockade;Immunogenomics;Immunologics;Immunooncology;Immunotherapy;improved outcome;Individual;Malignant Neoplasms;Modeling;Molecular;Mutation;Patients;Phenotype;pre-clinical;Pre-Clinical Model;programmed cell death ligand 1;programmed cell death protein 1;programs;Research;Resistance;response;Sampling;side effect;Somatic Mutation;Therapeutic;Treatment Efficacy;tumor;Tumor Immunity;Work

PROJECT_TITLE: Towards Precision Immuno-Oncology: Unraveling the Genomic Determinants and Mechanisms Underlying Immunotherapy Efficacy and Resistance


NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Lung;Rare Diseases

PI_NAMEs: MCCARTY, NAEL A (contact)

PROJECT_TERMS: Adherence;Advertisements;base;Behavioral;Bone Diseases;Budgets;Chronic;clinical care;cohesion;Collaborations;Communication;Communities;Consultations;Creativeness;Cystic Fibrosis;cystic fibrosis related diabetes;Diet;Disease;Effectiveness;Electronics;Evaluation;Exercise;Faculty;Funding;gastrointestinal function;Goals;Growth;health equity;Institution;Knowledge;Leadership;Life Style;Liver diseases;liver function;meetings;member;Mentors;Metabolism;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Newsletter;Nutritional status;outreach;Physicians;Problem Solving;Process;Productivity;programs;recruit;Reporting;Request for Applications;Research;Research Personnel;Research Support;Resources;Scientist;Services;Shapes;Sleep;Strategic Planning;symposium;Systemic disease;Training Activity;translational impact;Translations;Universities;web site

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Glioblastoma (GBM) is the most common and deadliest primary brain tumor, and current standard-of-care has demonstrated limited success. We propose to develop a novel peptide-platinum(IV) drug conjugate that can selectively recognize and target GBM tumors. Findings from this proposal could ultimately benefit GBM patients in the clinic through extending survival and improving quality of life.

PI_NAMEs: CHO, CHOI-FONG  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Adult;Aftercare;Antineoplastic Agents;Binding;Biodistribution;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier disruption;blood-brain barrier penetration;Brain;Brain Neoplasms;brain tissue;brevican;cancer therapy;Cells;Central Nervous System;Chemistry;chemotherapy;Clinic;Clinical;Collaborations;Combined Modality Therapy;Cryoultramicrotomy;cyanine dye 5;Cytoprotection;cytotoxicity;Data;Development;Dextrans;Disease;Dose;Drug Delivery Systems;Drug Kinetics;Dyes;effective therapy;Effectiveness;efficacious treatment;efficacy evaluation;Excision;Exhibits;Extracellular Matrix;Glioblastoma;Glioma;Glycoproteins;Guidelines;Harvest;Human;IACUC;improved;In Vitro;in vivo;Inductively Coupled Plasma Mass Spectrometry;Injections;innovation;Intervention;Intracranial Neoplasms;intravenous injection;Kinetics;Magnetic Resonance Imaging;Malignant Neoplasms;Maximum Tolerated Dose;Measures;Modeling;mouse model;Mus;Nature;neoplastic cell;neuro-oncology;Normal tissue morphology;novel;novel therapeutics;Nude Mice;Operative Surgical Procedures;Organ;Organoids;Patients;Peptides;Permeability;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Plasma;Platinum;pre-clinical;prevent;Primary Brain Neoplasms;Prodrugs;Protein Isoforms;Quality of life;Radiation therapy;Recombinant Proteins;Recurrence;Research;Serum;Specificity;Specimen;standard of care;stem cells;success;Surface;targeted delivery;temozolomide;Therapeutic;therapeutic target;Time;Tissues;tool;Toxic effect;Treatment Efficacy;tumor;uptake;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting platinum(IV) prodrug to GBM tumors using a brevican-binding peptide

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(56)R]


ED_INST_TYPE: SCH OF BUSINESS/PUBLIC ADMIN

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Patients with neurodevelopmental disorders such as autism and ADHD often deal with sensory processing issues that disrupt their daily lives, likely due to a failure in the attentional mechanism that selectively prioritizes a subset of sensory information, but the underlying cause of these issues is poorly understood because of gaps in our understanding of basic attentional mechanisms. By elucidating fundamental neural mechanisms of attention in multisensory contexts, results from the proposed research will lead to a better understanding of sensory processing issues and, ultimately, could lead to treatments that help patients better manage sensory stimuli.

PI_NAMEs: WEGNER-CLEMENS, KIRA  (contact)

PROJECT_TERMS: angular gyrus;Attention;Attention deficit hyperactivity disorder;Auditory;autism spectrum disorder;Canis familiaris;Cephalic;Cognitive;Disease;Distress;Environment;Event;Failure;Felis catus;Frequencies;Human;Image;Inferior frontal gyrus;Investigation;Life;Location;Magnetic Resonance;Magnetism;Measures;Methods;multisensory;neurodevelopment;Neurodevelopmental Disorder;neuromechanism;Organ;Participant;Patients;Perception;Process;Research;Rest;Role;semantic processing;Semantics;Sensory;sensory integration;sensory stimulus;sensory system;Signal Transduction;sound;Source;Speed;Stimulus;Symptoms;targeted imaging;Testing;Time;Vision;Visual;Visual Cortex;visual search

PROJECT_TITLE: Neural mechanisms of semantic guidance of audiovisual attention


NIH_SPENDING_CATS: Behavioral and Social Science;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: ESCOFFERY, NGOC-CAM  (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;Affect;Age;American;barrier to care;behavior change;Behavioral;Behavioral Sciences;Big Data;career;Caring;Clinical;Collaborations;Communities;community engaged research;community engagement;Community of Practice;community organizations;community partners;comorbidity;Complex;Consult;Consultations;Data Analyses;Data Analytics;design;Development;diabetes management;Diabetes Mellitus;Diabetes prevention;diabetes risk;digital technology;Disease;Disparate;Disparity;disparity reduction;Education;Equity;Ethics;Ethnic Origin;evidence base;Fostering;Gender;Geography;Grant;Health;health determinants;health disparity;health disparity populations;health equity;Health Technology;implementation research;implementation science;improved;innovation;innovative technologies;Insulin;intersectionality;Intervention;Knowledge;lens;Measurement;Measures;Mentors;Methodology;Methods;Minority Groups;minority investigator;Modeling;Morehouse School of Medicine;multidisciplinary;Outcome;Patients;Pilot Projects;Policies;Population;Prevalence;Prevention;Process;programs;Public Health;Race;Recording of previous events;recruit;remote technology;Research;Research Methodology;Research Personnel;Risk;Self Management;sexual identity;social;social vulnerability;Socioeconomic Status;success;Technology;theories;translational engagement;Translational Research;Translations;Underrepresented Minority;Underserved Population;Universities;uptake;Vulnerable Populations;wearable device;Work

PROJECT_TITLE: Socioecological and Behavioral Science for Equity Core


ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Jointly led by the University of Chicago and Northwestern University, the Chicago Center for Diabetes Translation Research (CCDTR) will provide core resources in Intervention Design and Implementation Science; Research Design, Data, and Analytics; Community Engagement and Health Equity; and Accelerating Health Equity And Eliminating Diabetes Disparities in Community Health Centers (AHEAD-CHC) that catalyze and support innovative and rigorous translational research to advance health equity for the prevention and management of diabetes. The CCDTR will increase the impact of rigorous diabetes translational research to reduce disparities in Chicago and the nation by organizing partnerships across academic institutions and stakeholder groups into working groups that include: Clinician-Patient Relationship and Shared Decision Making, Social Determinants of Health, Diabetes Prevention, Diabetes Modeling, Organization and Financing of Care (focusing in Community Health Centers and Medicaid), Diabetes and Aging. The CCDTR will attract and support diverse investigators who are new to the area of diabetes translational research by providing education, training, mentoring, support for community and stakeholder engagement, pilot and feasibility seed grants, and access to critical translational research core resources.

PI_NAMEs: ACKERMANN, RONALD T.;CHIN, MARSHALL H (contact)

PROJECT_TERMS: Acceleration;Address;African American;age group;Aging;Area;Asian Americans;base;Behavioral;Biological;built environment;Career Mobility;Caring;Chicago;Cities;Clinical;Communities;community engagement;Data;diabetes management;Diabetes Mellitus;Diabetes prevention;Direct Costs;Disparity;disparity reduction;Education;Educational workshop;Environment;Equity;ethnic disparity;ethnic minority population;Ethnic Origin;Evidence based intervention;Grant;Health Disparities Research;health disparity;health equity;Health Resources;Healthcare;Healthcare Systems;implementation science;improved;Income;Individual;Inequity;Infrastructure;innovation;Institution;Intervention;Knowledge;Latinx;Low income;Medicaid;member;Mentors;Midwestern United States;minority health;minority health disparity;Modeling;Names;Neighborhood Health Center;Neighborhoods;Patients;Persons;Policies;Population;population health;Poverty;Prevention;programs;racial disparity;racial diversity;racial minority population;racism;Research;Research Design;Research Methodology;Research Personnel;Research Support;Resources;Risk;Role;Rural;Scientist;Severities;shared decision making;skills;social culture;social health determinants;socioeconomic disparity;structural determinants;therapy design;Training;Translating;Translational Research;United States National Institutes of Health;Universities;Visit;Vulnerable Populations;Work;working group


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: COLUMBUS

ORG_NAME: CYTONUS THERAPEUTICS, INC.

PHR: Narrative. Cancer is a systemic disease and conventional treatment strategies that are administered systemically, ultimately fail due to an inability to achieve antitumor efficacy at tolerable doses for the patient. Cytonus has developed a first-in-class, precision delivery platform, called CargocytesTM, that is a safe and effective means to target therapeutic drugs to primary and secondary tumors. In this phase II study, we will evaluate the therapeutic efficacy of systemically-delivered, locally-active, membrane-tethered or secreted IL-12 to induce durable systemic antitumor and antimetastatic immunity.

PI_NAMEs: FILARDO, EDWARD J (contact)

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: adaptive immunity;Adjuvant;Anatomy;Animals;anti-PD1 antibodies;anti-tumor immune response;Binding;Biological;Body Weight;bone;Brain;Breast;cancer cell;Cancer Center;Cancer Patient;CD8-Positive T-Lymphocytes;Cell Nucleus;Clinical;clinical development;Clinical Treatment;conventional therapy;cytotoxic;delivery vehicle;design;Development;Diagnosis;Disease;Dose;effective therapy;efficacy evaluation;Engineering;Genetic Engineering;Genomic DNA;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Health;Histopathology;Home;Homing;Hour;IL2RA gene;Immune;immune checkpoint blockade;Immune system;Immune Tolerance;Immunity;Immunologic Markers;Immunologics;Immunooncology;Immunosuppression;improved;In complete remission;innovation;Interferon Type II;Interleukin-12;Interleukin-15;Intravenous;intravenous administration;Lead;Legal patent;Licensing;Liver;Lung;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Medicine;Membrane;mesenchymal stromal cell;Metastatic Neoplasm to the Lung;Modeling;Mouse Mammary Tumor Virus;mouse model;Mus;Natural Immunity;Neoplasm Metastasis;neoplastic cell;Organ;Organelles;Patients;Penetration;Peripheral;Pharmaceutical Preparations;Phase;phase 2 study;polyoma middle tumor antigen;pre-clinical;Pre-Clinical Model;preservation;prevent;Primary Neoplasm;programs;Property;Refractory;Regulatory T-Lymphocyte;response;Route;Safety;Serum;success;Surface;System;Systemic disease;targeted treatment;technology platform;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;therapeutically effective;Time;Toxic effect;Treatment Efficacy;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor heterogeneity;Tumor Immunity;tumor microenvironment;Tumor Tissue;tumorigenesis;Work

PROJECT_TITLE: Development of CA-IL-12 for Triple Negative Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-R(12)B]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: Project Narrative The mammalian brain is the most energy efficient, compact, adaptable, intelligent system that we know and understanding it will have a profound impact in our society, technology, economy and mental health. Critical to this understanding is the knowledge about the synaptic structure of neural circuits because it provides strong constraints on the nature of the computations the brain performs, as well as knowledge of gene expression because it provides constraints on how this structure is built and operates. The goal of the proposed research is to create the technologies to scale synapse mapping to a whole mouse brain and integrate this knowledge with gene expression data using as biological model and feasibility test the Cortico-Thalamic-Basal-Ganglia loop.

PI_NAMEs: COLLMAN, FORREST CHRISTIE;MACARICO DA COSTA, NUNO  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: addiction;Animals;Area;Atlases;Automation;Basal Ganglia;Behavior;Biological Models;Brain;BRAIN initiative;Caenorhabditis elegans;Calcium;Cell Physiology;cell type;Cells;Collection;Community Health Education;computerized data processing;connectome;cost;Coupled;Data;data acquisition;Data Compression;data integration;data management;data mining;Data Set;deep learning;Detection;Development;Disease;disease model;dissemination strategy;dopaminergic neuron;Dorsal;Drosophila genus;Education and Outreach;Electron Microscopy;electron tomography;Elements;energy efficiency;Ensure;Environment;Expert Systems;feasibility testing;Film;Gene Expression;Generations;Goals;Image;imaging modality;improved;Individual;Infrastructure;innovative technologies;insight;Knowledge;knowledge integration;Learning;Life Cycle Stages;Light;light microscopy;Link;Maps;Medial;member;Memory;Mental Health;Methods;Microscope;Microscopic;microscopic imaging;millimeter;Modeling;Morphology;Movement;multimodality;Mus;Nature;neural circuit;neural model;Neurons;Neurosciences;next generation;open data;open source;Output;Parkinson Disease;patch sequencing;Phase;Preparation;Process;programs;Protocols documentation;Psychological reinforcement;reconstruction;Research;Resolution;Rewards;Route;Sampling;scaffold;scale up;Science;Scientist;self supervised learning;Societies;software development;Software Tools;Source;Stains;Standardization;Structure;Synapses;System;Technology;Testing;Thalamic Nuclei;Thalamic structure;Thick;Thinking;Time;tomography;tool;transcriptomics;Transmission Electron Microscopy;Ventral Tegmental Area;Work;X-Ray Computed Tomography;X-Ray Tomography

PROJECT_TITLE: BRAIN CONNECTS: Center for a pipeline of high throughput integrated volumetric electron microscopy for whole mouse brain connectomics


NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Diabetes;Digestive Diseases;Liver Disease;Lung;Nutrition;Rare Diseases

PI_NAMEs: ALVAREZ, JESSICA ALEJANDRA (contact)

PROJECT_TERMS: absorption;Address;Adult;Adverse event;Affect;analytical tool;Area;Basic Science;Beta Cell;bone;Caring;Cell Physiology;Center Core Grants;Child;Climacteric;Clinical;clinical center;Clinical Research;clinical training;cohort;Collaborations;Communities;comorbidity;Consultations;Continuous Glucose Monitor;Cystic Fibrosis;cystic fibrosis patients;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Data Analyses;data warehouse;Databases;Diabetes Mellitus;Diagnostic;Disease;Doctor of Philosophy;Early Diagnosis;Endocrine;Endocrinology;ethnic diversity;evidence base;Faculty;Fatty Liver;follow-up;Functional disorder;Funding;Future;gastrointestinal;gastrointestinal symptom;Glucose Intolerance;Goals;graduate student;Health;Hepatic;Hepatology;Impairment;improved;Individual;Influentials;insulin sensitivity;Interdisciplinary Study;interest;Leadership;life span;Link;Liver;Liver diseases;liver stiffness;Longevity;Lung Diseases;Measurement;microbiome;Modality;mortality;mortality risk;novel;nutrition;OGTT;Outcome;Outcome Measure;outreach;Patient Outcomes Assessments;Patients;Persons;Pharmaceutical Preparations;Phenotype;Postdoctoral Fellow;pulmonary function;Quality of life;Race;rare variant;recruit;repaired;Research;Research Design;Research Personnel;Research Priority;Research Support;Resources;response;Risk Factors;Services;sexual and reproductive health;side effect;Testing;tool;Training;training opportunity;Translational Research;translational scientist;Translations;undergraduate student;Universities

PROJECT_TITLE: Core 1, DEG


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: HADLEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: NARRATIVE Ca2+/calmodulin dependent protein kinase II (CaMKII) plays significant roles in neurons, cardiomyocytes, and oocytes. We are fascinated by the multifunctional roles CaMKII plays in human health and will interrogate this important problem using a combinatorial approach from transcriptomics to cell biology.

PI_NAMEs: STRATTON, MARGARET M (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Affect;Alternative Splicing;Biochemistry;Biological;calmodulin-dependent protein kinase II;Cardiac;Cardiac Myocytes;Cell Communication;cell type;Cells;Cellular Assay;Cellular biology;Chemicals;combinatorial;Communication;Complex;Coupled;Enzymes;Event;fascinate;Fertilization;Genes;Health;Human;Infertility;intercellular communication;interest;long term memory;Mammals;millisecond;Modification;Molecular;Molecular Conformation;Myocardial dysfunction;Nervous System Disorder;Neurons;Oocytes;Organism;Output;Physiology;Play;Production;Proteins;Regulation;RNA Splicing;Role;structural biology;Therapeutic Intervention;Transcript;transcriptomics;Variant;Work

PROJECT_TITLE: Unraveling the molecular events driven by CaMKII in Ca2+-coupled cells

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Telehealth

PI_NAMEs: PASQUEL, FRANCISCO J (contact)

PROJECT_TERMS: Acceleration;Address;Administrator;Adoption;Area;Artificial Intelligence;Big Data;Caring;Cellular Phone;clinical decision support;clinical practice;Collaborations;Communication;Communities;Community Practice;Consultations;Continuity of Patient Care;cost effective;COVID-19 pandemic;Decision Support Systems;diabetes management;Diabetes Mellitus;Diabetes prevention;Disparity;Disparity population;disparity reduction;education resources;Electronic Health Record;Electronic Mail;Equity;Evaluation;Exhibits;Florida;Funding;Goals;Grant;Health;health care disparity;health disparity;health management;Health Technology;Healthcare;Healthcare Systems;implementation barriers;implementation science;improved;Inequity;innovation;Institution;Insulin;Internet;interoperability;Knowledge;learning network;Low income;Marketing;member;Methodology;multiple chronic conditions;older patient;Outcome;Ownership;Patients;peer;peer networks;Persons;Population;population health;Prevention;programs;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;remote monitoring;Research;Research Personnel;Research Support;Risk;Role;social media;Socioeconomic Status;Southeastern United States;Structure;success;Surveys;Technology;Technology Assessment;telehealth;Tennessee;Time;Translational Research;Translations;Underserved Population;uptake;usability;Viral;virtual;Vulnerable Populations;wearable device;web site;Work

PROJECT_TITLE: Technologies Advancing Translation and Equity - Regional Core


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE Human BAT functions as a metabolic sink for lipids, glucose, and amino acids and dissipates nutrient-derived energy in the form of heat. The outcomes from the proposed study will advance our understanding of how BAT orchestrates metabolic utilization of various substrates for heat production.

PI_NAMEs: CHANG, JI SUK  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Acetylation;Adipocytes;Adipose tissue;Adrenergic Agents;Adrenergic Receptor;alpha ketoglutarate;Amino Acids;Animals;Aspartate;Binding;Biochemical;Biosensor;Brown Fat;Cells;Circulation;Complex;Cyclic AMP-Dependent Protein Kinases;Cytosol;Data;Deuterium;Electron Transport;Energy Metabolism;Enzymes;fatty acid oxidation;Fatty Acids;Gene Expression;Generations;Genes;Glucose;Glutamates;Glycolysis;Goals;GOT1 gene;Human;improved;Knock-out;Knockout Mice;Label;Link;Lipids;Malate-Aspartate Shuttle Pathway;Malates;Mediating;Metabolic;mimetics;Mitochondria;Molecular;Mus;mutant;NADH;Natural regeneration;Nutrient;Outcome;Outcome Study;overexpression;Oxaloacetates;oxidation;Palmitates;pharmacologic;Phosphorylation;Phosphorylation Site;Physiology;Play;Production;promoter;Proteins;Protons;Pyruvate;Receptor Signaling;Regulation;Resolution;Respiration;response;Rodent;Role;Signal Pathway;Signal Transduction;SIRT1 gene;Spirometry;stable isotope;System;Techniques;Testing;Thermogenesis;Tissues;Transcriptional Regulation;Transgenic Organisms;ubiquitin-protein ligase;Ubiquitination;uptake

PROJECT_TITLE: Regulation of brown fat fuel utilization by the malate-aspartate shuttle

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Cancer;Clinical Research;Orphan Drug;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE: Cancer-associated fibroblasts (CAFs) plan an essential role in the tumor microenvironment for numerous tumor types and may be important in the development of aggressive thyroid cancers such as anaplastic thyroid carcinomas (ATCs). In this proposal, we will study the role of CAFs, as well as their paracrine Wnt signaling, in ATCs using single-cell sequencing, spatial transcriptomics, novel thyroid cancer organoids with corresponding CAF cultures, and a patient-derived xenograft mouse model to discover potential new therapy for anaplastic thyroid carcinoma.

PI_NAMEs: WEISS, VIVIAN LEE (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Academic Medical Centers;Adhesions;Aggressive behavior;anaplastic thyroid cancer;Autocrine Communication;Behavior;Benign;Binding;biobank;Biological Markers;Biology;biomarker identification;cancer type;cell dedifferentiation;Cells;Cellularity;Clinical Trials;cohort;Colon Carcinoma;Data;Detection;Development;Diagnostic;Disease;Disease Progression;Disease Resistance;effective therapy;efficacy evaluation;fibroblast activation protein alpha;fibroblast-activating factor;Fibroblasts;Future;Goals;Grant;Heterogeneity;Immunofluorescence Immunologic;improved;in vivo;Indolent;inhibitor;Institution;Invaded;Lead;Ligands;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of thyroid;Malignant Neoplasms;Mediating;Modeling;Molecular;Morphology;mouse model;Mutation;neoplastic;neoplastic cell;Neoplastic Processes;new therapeutic target;Nomenclature;novel;novel therapeutics;Organoids;Pancreas;Papillary thyroid carcinoma;paracrine;Paracrine Communication;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phenotype;Play;Population;prevent;Proliferating;Proteins;proto-oncogene protein Wnt-2;receptor;recruit;refractory cancer;Research;Role;Signal Transduction;single cell sequencing;single-cell RNA sequencing;standard of care;stem;Stromal Neoplasm;Study models;Supporting Cell;targeted cancer therapy;targeted treatment;Tenascin;Testing;Therapeutic;therapeutic target;therapeutically effective;Thyroid carcinoma;Thyroid Diseases;Thyroid Gland;thyroid neoplasm;Tissues;transcriptomics;Treatment-Related Cancer;triple-negative invasive breast carcinoma;tumor;tumor behavior;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Universities;Washington;WNT Signaling Pathway;Xenograft procedure

PROJECT_TITLE: The Role of Cancer-Associated Fibroblasts in Thyroid Carcinoma

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Cystic Fibrosis;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Rare Diseases;Social Determinants of Health

PROJECT_TERMS: Acceleration;actigraphy;Address;Adult;Award;Awareness;Behavior;Behavior assessment;behavior measurement;Behavioral;behavioral outcome;biobehavior;Biological Aging;Body Composition;Cardiopulmonary;Child;Childhood;children with cystic fibrosis;Clinic;Clinical;clinical investigation;Clinical Investigator;Clinical Research;Collaborations;Collection;Communities;Consultations;Cystic Fibrosis;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Data Analyses;data dissemination;data warehouse;Databases;Diet;Dietary intake;Energy Metabolism;Enrollment;ethnic minority population;Evaluation;evidence based guidelines;Exercise;Exercise Physiology;Exercise Test;Exercise Tolerance;Exhibits;Experimental Designs;follow-up;Funding;Future;Glucose Intolerance;Goals;health disparity;health inequalities;Home;improved;Inpatients;Interdisciplinary Study;Investigation;Knowledge;life span;Life Style;Link;Longevity;Lung;Methodology;Morbidity - disease rate;mortality;novel;nutrition;Nutritional;Nutritional status;Obesity;Outcome;Outcome Study;Outpatients;Overweight;Participant;Persons;Pharmaceutical Preparations;Phenotype;Physical activity;Population;Prevalence;Protocols documentation;Quality of life;racial minority population;Research;Research Personnel;response;Services;Sleep;Survival Rate;Testing;Training;Translating;translational study;Translations;Universities

PROJECT_TITLE: Core 2, NLB


NIH_SPENDING_CATS: Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: DUNBAR, SANDRA B. (contact)

PROJECT_TERMS: Address;Age;Area;Award;base;Behavioral;Behavioral Sciences;career;catalyst;Clinical;clinical center;Collaborations;Communities;community engaged approach;community engagement;comorbidity;Consultations;Data Set;design;Development;Diabetes Mellitus;Educational workshop;Ensure;Equity;Ethnic Origin;Evaluation;experience;Extramural Activities;Faculty;Florida;Funding;Funding Opportunities;Future;Gender;geographic disparity;Geography;Grant;Health;health determinants;health disparity;health equity;health equity promotion;Health equity research;health inequalities;health management;implementation research;Individual;innovation;Institution;Investments;K-Series Research Career Programs;Knowledge;Link;member;Mentors;Mentorship;Methodology;Methods;mHealth;minority investigator;mobile computing;Modeling;Monitor;multidisciplinary;new technology;Outcome;peer coaching;Peer Review;Pilot Projects;Policies;population health;Population Heterogeneity;Process;Productivity;programs;Publications;Race;Recording of previous events;Research;research and development;research data dissemination;Research Personnel;Resources;Role;Science;Scientific Inquiry;Services;Sex Orientation;skill acquisition;skills;skills training;Socioeconomic Status;socioeconomics;Southeastern United States;success;symposium;Technology;Tennessee;Testing;theories;Training Activity;Translational Research;translational scientist;Translations;Underrepresented Minority;United States National Institutes of Health;Vulnerable Populations;Work;Writing

PROJECT_TITLE: Pilot & Feasibility Program


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Adipose tissue is a promising target for treating obesity and metabolic diseases. However, pharmacological agents usually fail to engage adipocytes due to their extraordinary size and insufficient vascularization in obese subjects. We propose connecting adipocytes via Connexin43 gap junctions improves the efficacy of pharmacological agents targeting adipose tissue, and we will use FGF21 as an example to test this hypothesis.

PI_NAMEs: ZHU, YI  (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;Adrenergic Agonists;Agonist;analog;blood glucose regulation;Body Weight decreased;Brain;Brain region;brain tissue;Brown Fat;Cells;Chemosensitization;Clinical Trials;Connexin 43;Connexins;Coupling;Data;Development;diabetic patient;Diffusion;Energy Metabolism;fibroblast growth factor 21;gap junction channel;Gap Junctions;Genetic Models;glycemic control;Hormones;Human;hydrophilicity;Hyperglycemia;improved;insight;insulin sensitivity;Lipids;Literature;Liver;Mediating;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Modeling;mouse model;Mus;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;obese patients;obese person;Obesity;Organ;overexpression;Peripheral;pharmacologic;Pharmacologic Substance;Process;Protein Isoforms;Proteins;Proteomics;Publications;Refractory;Respiration;response;Rodent;Safety;Serum;Signal Transduction;targeted agent;Testing;Therapeutic;Tissues;Triglycerides;Type 2 diabetic;Vascularization;Work

PROJECT_TITLE: Enhancing metabolic action of FGF21 through adipocyte Connexin43 gap junction channels

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer;Prevention

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE The sixth renewal of the University of Texas Health Science Center at Houston (UTHealth) School of Public Health training program builds on a 29-year track-record preparing fellows (many from underrepresented minority groups) to become independent, skilled, and principled cancer control scientists. The training program is designed to prepare cancer prevention and control researchers to fill evidence gaps about multi- level causes of cancer-related inequities; to develop and evaluate cancer control multilevel interventions (MLIs); and develop and test strategies to increase the adoption, implementation, sustainment, and scale up of effective interventions in community and health care settings. Ultimately, the long-term goal of the proposed training program is to reduce cancer morbidity and mortality and decrease cancer-related health inequities.

PI_NAMEs: BALASUBRAMANIAN, BIJAL A.;FERNANDEZ, MARIA EULALIA (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Cancer Control Research;cancer prevention;career development;Program Development;Research Training

PROJECT_TITLE: Cancer Prevention and Control Research Training and Career Development Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: UMPIERREZ, GUILLERMO E (contact)

PROJECT_TERMS: Applications Grants;Archives;Area;Behavioral Sciences;career life balance;Caring;Clinic;Clinical;cohesion;Collaborations;Communication;Communities;community academic partnership;community organizations;community partnership;design;Development;Diabetes Mellitus;diversity and equity;Education;Educational workshop;Ensure;Environment;Equity;Evaluation;Event;experience;Faculty;Federally Qualified Health Center;Female;Florida;Fostering;Funding;Grant;Health;health disparity;improved;innovation;Institution;International;Interview;K-Series Research Career Programs;Knowledge;lectures;Link;live stream;Manuscripts;medical schools;member;Mentors;Minority Groups;minority investigator;Mission;Morehouse School of Medicine;multidisciplinary;outreach;peer;peer coaching;peer support;Persons;Physicians;Play;Postdoctoral Fellow;preference;Preparation;Prevention;Problem Solving;programs;Public Health Schools;RADx Underserved Populations;repository;Research;Research Methodology;Research Personnel;Role;Scientist;skill acquisition;skills;social media;Southeastern United States;Support Groups;supportive environment;Surveys;symposium;Teacher Professional Development;Technology;Tennessee;Time Management;tool;Translational Research;Translations;Underrepresented Minority;Universities;Update;virtual;Visit;web site;Work;working group;Writing

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Networking and Information Technology R&D (NITRD);Rare Diseases

PI_NAMEs: STECENKO, ARLENE A (contact)

PROJECT_TERMS: Acceleration;Award;Behavioral;Bioinformatics;Biometry;Center Core Grants;Clinical;Clinical Data;Clinical Informatics;Clinical Research;cloud based;cohort;Collaborations;Communities;comorbidity;Computer Analysis;computer infrastructure;Cystic Fibrosis;Data;data access;Data Analyses;data dissemination;data integration;data management;data quality;Data Scientist;data sharing;data warehouse;Database Management Systems;Databases;design;Development;Disease;Elderly;Engineering;Ensure;Experimental Designs;Faculty;federated database;Fostering;Functional disorder;Funding;Goals;Grant;health disparity;Housing;Human Subject Research;improved;Individual;Infrastructure;innovation;Institution;Interdisciplinary Study;Knowledge;Laboratory Research;Molecular;novel;Outcomes Research;Participant;Persons;Phenotype;Physiological;Process;protocol development;Pulmonary Cystic Fibrosis;Quality of life;repository;Research;Research Design;Research Personnel;Research Project Grants;research study;Resources;Retrieval;Scientist;Secure;Services;sound;Source;Statistical Data Interpretation;success;System;Technology;Time;Toddler;tool;Training;Translational Research;Translations;Universities

PROJECT_TITLE: Core 3, CRIC


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Social Determinants of Health

ORG_CITY: GREENSBORO

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA AGRI & TECH ST UNIV

ORG_STATE: NC

PHR: Project Narrative The post genomic era requires interdisciplinary collaborative technology-driven research built upon computational genomics, data sciences, and cloud computing. A lack of organized resources such as faculty trained in these disciplines, adequate computing resources, and the instrumentation for conducting genomic research has contributed to the STEM Talent deficit particularly among historically marginalized communities. Through the creation of the Genomic Research and Data Science Center for Computational Cloud-Computing (GRaDS-4C) we seek to provide the educational and hands-on research training and resources in computational genomics, data sciences, and cloud computing for the future workforce particularly among underserved student populations at NCA&TSU and other target HBCU/MSI institutions.

PI_NAMEs: DOSS, CHRISTOPHER C;GRAVES, JOSEPH L;HARRISON, SCOTT H.;MUGANDA, PERPETUA M;RHINEHARDT, KRISTEN  (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Acceleration;Address;Agriculture;Area;Awareness;Biology;career preparation;cloud based;Cloud Computing;Companions;Complex;computational platform;computing resources;Data Science;Databases;Development;Discipline;Diverse Workforce;Education;education resources;Educational Materials;Educational process of instructing;Educational workshop;Environment;Faculty;Funding;Future;Generations;Genomics;Goals;hands on research;hands-on learning;health disparity;High Performance Computing;Historically Black Colleges and Universities;innovation;Institution;instrumentation;interest;learning materials;marginalized community;marginalized population;Medicine;minority student;Minority-Serving Institution;North Carolina;open source;Population;recruit;Research;Research Personnel;Research Training;Resources;Science;Scientist;Site;Societies;student training;Students;success;symposium;Systems Biology;Talents;Teacher Professional Development;Technology;Testing;Training;Training and Education;Trust;Underserved Population;underserved students;United States National Institutes of Health;Universities;university student;webinar;Work

PROJECT_TITLE: Genomic Research and Data Science Center for Computation and Cloud-Computing


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Cell division is an essential process by which replicated chromosomes are equally segregated to daughter cells, however this process is prone to errors, which can result in chromosomal instability and lead to cancer and developmental diseases. There are potential molecular mechanisms contributing towards faithful chromosome segregation that have not yet been adequately explored, one of which is the evolution and maintenance of chromosome organization throughout mitosis. Our proposed work of defining the spatial organization of mitotic chromosomes and kinetochores required for accurate chromosome segregation using innovative imaging methods is of fundamental importance to public health because a clear understanding of the mechanisms underlying faithful chromosome segregation will contribute towards developing better therapeutic and detection strategies for cancer and developmental diseases for improved patient outcomes.

PI_NAMEs: SUZUKI, AUSSIE  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: 3-Dimensional;Aneuploidy;aurora B kinase;Binding;Calibration;Cell division;Cell Nucleus;Cells;Centromere;Chromatin;Chromosomal Instability;chromosome loss;Chromosome Positioning;chromosome replication;Chromosome Segregation;Chromosome Structures;Chromosome Territory;Chromosomes;Computer software;Coupled;daughter cell;Defect;Detection;developmental disease;Ensure;Evolution;Frequencies;Gene Expression Regulation;Genomics;Goals;imaging modality;improved;Individual;innovation;insight;Interphase;Kinetochores;Maintenance;Malignant Neoplasms;Mammalian Cell;Mediating;Methods;Microtubules;Mitosis;Mitotic;Mitotic Chromosome;Molecular;Needles;Pathway interactions;Patient-Focused Outcomes;Phosphorylation;Phosphotransferases;Positioning Attribute;Process;protein structure;Proteins;Public Health;Quantitative Microscopy;Regulation;segregation;spatiotemporal;superresolution microscopy;Testing;Therapeutic;Tumor Promotion;Work

PROJECT_TITLE: Chromosome dynamics and organizations necessary for faithful chromosome segregation

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: CHIN, MARSHALL H (contact)

PROJECT_TERMS: Acceleration;Aging;Area;base;Binding;Caring;Chicago;Clinical;Communication;Communities;community engagement;Data;diabetes management;Diabetes Mellitus;Diabetes prevention;Disparity;disparity reduction;Education;Ensure;experience;Goals;Grant;health equity;implementation science;innovation;Institution;Joints;Medicaid;meetings;member;Mentors;Mentorship;Midwestern United States;Modeling;Neighborhood Health Center;operation;Patients;Prevention;programs;Public Health;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;Sanguisorba;shared decision making;social health determinants;symposium;therapy design;Training;Translational Research;translational scientist;Universities;web site;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Neuroscience is a rapidly evolving discipline that requires rigorous fundamental training to broaden our understanding of the nervous system and the many incurable and debilitating disorders that impact it. The goal of the proposed program is to provide doctoral students a comprehensive, multidisciplinary training program buoyed by strong quantitative and analytical training to produce the next generation of neuroscientists to tackle these important problems.

PI_NAMEs: GRUEBER, WESLEY B (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Behavior;Grant;Neurobiology;Training

PROJECT_TITLE: Neurobiology and Behavior training grant


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: We propose tightly integrated theory and experimentation to elucidate neural mechanisms of visually guided control of steering. Deficits in perceiving self-motion are among the earliest consequences of Alzheimer's disease, and can substantially impact patients' lives, including their ability to drive a vehicle. By understanding how optic flow processing is integrated with motor and memory signals to control steering, our work will reveal neural mechanisms by which Alzheimer’s disease may influence driving and how these deficits might be mitigated.

PI_NAMEs: DEANGELIS, GREGORY C (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: active control;Alzheimer's Disease;Amblyopia;Animal Model;Animals;Area;Automobile Driving;Behavior;Behavioral;behavioral study;Biological Models;Brain;Compensation;control theory;cost;Data;density;design;Destinations;Distant;Environment;experience;experimental study;Goals;Health;Human;Joystick;Knowledge;Link;Location;Macaca;member;Memory;Modeling;Monkeys;Motion;Motor;Movement;National Eye Institute;neural;neural correlate;neuromechanism;Neurons;neurophysiology;neuroregulation;neurotransmission;novel;Occipital lobe;optic flow;optimal control theory;Outcome;Patients;Pattern;Perception;Performance;Play;Population;Process;programs;Research;Research Priority;retinal imaging;Role;Self Perception;Sensory;sensory input;Short-Term Memory;Signal Transduction;Speed;Strabismus;Stream;Symptoms;Task Performances;Testing;theories;Time;Training;Travel;virtual;virtual environment;virtual reality;Vision;Visual;Visual Motion;visual processing;Work

PROJECT_TITLE: Neural mechanisms of optic flow processing for visually-guided control of steering

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Lung;Pediatric;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PI_NAMEs: MCCARTY, NAEL A (contact)

PROJECT_TERMS: Address;Adult;Airway Disease;Area;Asthma;Budgets;career;Center Core Grants;Child;Child health care;Child Support;Cities;Clinical;Clinical Research;Collaborations;Consultations;Cystic Fibrosis;cystic fibrosis related diabetes;design;Dietary Sugars;Eligibility Determination;Evaluation;Extramural Activities;Faculty;Feasibility Studies;Foundations;Funding;Funding Agency;Goals;Grant;Growth;Guidelines;health equity;high risk;impaired glucose tolerance;innovation;Institution;Interdisciplinary Study;Intervention;Investments;Leadership;Lung;Lung Diseases;Manuscripts;National Institute of Diabetes and Digestive and Kidney Diseases;novel;operation;Pathogenesis;Pediatric Research;Pilot Projects;Productivity;Program Development;programs;Recommendation;Recording of previous events;recruit;Research;research and development;Research Personnel;Research Priority;Research Support;Science;Source;Teacher Professional Development;Translational Research;Translations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Pilot & Feasibility Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Diabetes;Health Services;Precision Medicine;Prevention;Social Determinants of Health

PI_NAMEs: HUANG, ELBERT S. (contact)

PROJECT_TERMS: Aging;All of Us Research Program;Area;Biometry;Black race;Businesses;Caring;Chicago;clinical epidemiology;Clinical Trials;Collaborations;Communities;Community Health;Computer software;Cost Effectiveness Analysis;Data;Data Sources;Data Storage and Retrieval;Decision Analysis;Diabetes Mellitus;Diabetes prevention;Discipline;economic evaluation;Economics;Elderly;Electronic Health Record;Epidemiology;Evaluation;Fertilization;forging;Foundations;Genetic study;genetic testing;Geriatrics;glycemic control;Goals;Guidelines;Health;Health Care Costs;health care service utilization;health economics;Health Insurance;Healthcare;improved;Informatics;Infrastructure;innovation;insight;Insurance Claim Review;insurance claims;interest;Intervention;Laboratories;Life;life span;Link;Methodology;Methods;Modeling;models and simulation;National Health Insurance;Natural experiment;novel;Outcome;Outcome Assessment;Pathway Analysis;Patient Preferences;Patients;personalized medicine;Play;Policies;Policy Analysis;Population;pragmatic trial;preference;prevent;Program Evaluation;programs;psychobiology;Quality of Care;Quality of life;Quality of Life Assessment;Quasi-experiment;Recommendation;Recording of previous events;Research;Research Design;Research Institute;Research Methodology;Research Personnel;Research Project Summaries;Research Support;Resource-limited setting;Resources;Role;Science;Scientist;Series;social;Social Network;Social Sciences;Sociology;Solid;Technical Expertise;Translating;Translational Research;Universities;Vulnerable Populations

PROJECT_TITLE: Research Design, Data, and Analytics Core


NIH_SPENDING_CATS: Behavioral and Social Science;Disability Research;Rural Health;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: The University of Cincinnati PREP program (PREP@UC) will provide training to prepare recent college graduates from underrepresented minority groups, disadvantaged backgrounds or with disabilities (URM/DA) for entry into a biomedical doctoral program and successful completion of that program. PREP@UC will provide PREP Scholars with intensive mentoring, research training and an individually tailored program of academic preparation. The scholars will spend 75% of their time performing research and the remaining 25% time on other educational and mentoring activities.

PI_NAMEs: ALLISON, BRITTANY ;BACCEI, MARK L (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: academic preparation;academic program;Active Learning;Appalachian Region;Area;Authorship;Automobile Driving;Biomedical Research;Black race;career;Cities;college;College Preparation;Credentialing;Critiques;Data;Data Analyses;design;disability;Disabled Persons;disabled students;disadvantaged background;Discipline;Distress;Doctor of Philosophy;Education;education research;Educational process of instructing;Educational workshop;Effectiveness;efficacy evaluation;efficacy testing;empowerment;Ensure;Environment;Equity;Evaluation;Event;Evidence based program;experience;Faculty;faculty mentor;Family;family building;family support;Goals;graduate school;graduate school preparation;graduate student;Health;Health Service Area;higher education;Hispanic Populations;Home;Individual;Infrastructure;Institution;interest;Interview;Learning;Learning Skill;Life Experience;Location;Manuscripts;matriculation;Medical;Medical center;Medicine;Mentors;metropolitan;Minority Groups;Mission;neighborhood disadvantage;Occupations;Oral;Output;Paper;Pediatric Hospitals;peer;Peer Review;Persons;Population;Positioning Attribute;Postbaccalaureate;posters;Poverty;Program Evaluation;programs;Qualifying;Readiness;Reading;Recording of previous events;Records;recruit;Reporting;Research;Research Personnel;Research Training;resilience;Scholarship;Science;Scientist;Self Assessment;Self Efficacy;service programs;skills;social group;Social support;Students;Surveys;symposium;Time;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;United States;Universities;Visit;Work;Writing

PROJECT_TITLE: Biomedical Postbaccalaureate Research Education Program at the University of Cincinnati College of Medicine (PREP@UC)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE All genetic diseases and cancers ultimately begin with genetic variation or mutations, but not all genetic variants are pathogenic. Understanding the effects of these genetic variants on proteins is critical for determining which variants cause disease and which are part of background variation. We are developing bioinformatic and analytical tools for measuring proteins with variants in disease and applying them to study the health effects of carrying specific variants on protein misfolding in amyloidosis.

PI_NAMEs: SEARLE, BRIAN CHIH-SENG (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;Amyloidosis;analytical tool;Base Pairing;Benign;bioinformatics tool;Biology;Clinical;clinically actionable;Coupled;Data;Disease;DNA Sequence Alteration;driver mutation;Genetic Diseases;Genetic study;genetic variant;Genetic Variation;Genome;Genomics;Germ-Line Mutation;Health;Human;improved;Individual;interest;Libraries;Link;Malignant Neoplasms;Mass Spectrum Analysis;Measures;molecular phenotype;Mutagens;Mutation;Outcome;Pathogenicity;Patients;Peptides;Phenotype;Prealbumin;protein misfolding;Proteins;Proteome;Proteomics;Published Comment;Sensitivity and Specificity;Somatic Mutation;Time;tool;tumor;Validation;Variant;variant of unknown significance

PROJECT_TITLE: Investigating the functional impact of genetic variants in the human proteome

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Lung;Networking and Information Technology R&D (NITRD);Pediatric;Telehealth

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE Adolescents diagnosed with asthma have difficulties consistently completing disease self-management behaviors (e.g., taking medications as prescribed, monitoring symptoms), placing them at elevated risk for suboptimal asthma control and impaired quality of life. The proposed project will evaluate a mobile health intervention that provides personalized and adaptive support to improve asthma self-management in adolescents with suboptimal control. If successful, our smartphone-based intervention has potential to improve health outcomes for many adolescents diagnosed with asthma.

PI_NAMEs: CUSHING, CHRISTOPHER C (contact);FEDELE, DAVID A

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: adaptive intervention;Adherence;Adolescent;Adrenal Cortex Hormones;Affect;Age;Agonist;Algorithms;Asthma;Award;Behavior;behavior change;Behavior Therapy;Caring;Cellular Phone;Childhood Asthma;Chronic Disease;clinical trial protocol;Clinical Trials;clinically significant;cloud based;Cognition;Data;design;Development;Diagnosis;digital;digital technology;Disease;Distal;Dose;Ecosystem;Education;efficacy trial;Emotions;evidence base;experience;Feedback;Future;Goals;Guidelines;Health;Impairment;improved;Informal Social Control;Inhalation;interest;Intervention;intervention delivery;intervention effect;Maintenance;medication compliance;mHealth;mhealth interventions;Minority;mobile sensor;Modeling;Modification;Monitor;Morbidity - disease rate;Multi-Institutional Clinical Trial;multi-site trial;Outcome;Ownership;Patient Self-Report;Pattern;Pharmaceutical Preparations;Phase;phase 1 designs;pilot test;pilot trial;post intervention;primary outcome;Problem Solving;Process;programs;Protocols documentation;Quality of life;Randomized;recruit;Regimen;Research;Risk;satisfaction;Schools;Self Management;sensor;Site;skills;smartphone application;standard of care;Symptoms;Technology;technology intervention;Teenagers;theories;Time;United States;Update;usability;user centered design;Work;Youth

PROJECT_TITLE: Optimizing a Sensor-Enabled mHealth Intervention for Adolescents with Suboptimal Asthma Control

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


NIH_SPENDING_CATS: Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: PEEK, MONICA E (contact)

PROJECT_TERMS: Acceleration;Address;Area;Awareness;base;Chicago;Cities;clinical practice;Clinical Research;Collaborations;Communities;community engaged approach;community engaged research;community engagement;community partners;community partnership;Competence;cost;culturally appropriate intervention;Databases;Diabetes Mellitus;Disparity;Dissemination and Implementation;dissemination strategy;Education;Elderly;empowerment;ethnic minority;experience;Faculty;Fostering;Goals;health disparity;health equity;health equity promotion;Health equity research;Health system;Human;implementation strategy;improved;Individual;Inequity;Institution;Intervention;Leadership;Linguistics;Link;Lived experience;Low income;Medical;member;Neighborhoods;novel;Outcome;Patient-Focused Outcomes;Policies;population health;Prevalence;Process;programs;Protocols documentation;racial minority;Recording of previous events;Research;Research Personnel;Research Project Grants;Research Support;research to practice;Resources;segregation;Services;Sexual and Gender Minorities;Shoulder;social;social health determinants;Translating;Translational Research;translational scientist;Universities;University resources;Work

PROJECT_TITLE: Community Engagement and Health Equity Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Prevention;Telehealth

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Bariatric surgery is the most effective obesity treatment available, producing large and durable weight losses for a majority of patients. Unfortunately, 20-30% of patients who undergo bariatric surgery experiencer significant weight regain and recurrence of weight-related comorbidities. The proposed study will test the efficacy of a novel psychotherapeutic intervention, delivered remotely, to reverse weight regain and maintain the health benefits of bariatric surgery.

PI_NAMEs: BRADLEY, LAUREN E;SARWER, DAVID B (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: active method;Address;Adherence;Aftercare;bariatric surgery;Bariatrics;Behavior Control;behavior test;Behavior Therapy;Behavioral;Biological Markers;Body Weight;Body Weight decreased;Caring;Cellular Phone;Clinical Treatment;clinically significant;comorbidity;comparison control;comparison intervention;Control Groups;craving;design;Diabetes Mellitus;dietary;Eating;Eating Behavior;Ecological momentary assessment;Educational process of instructing;effective therapy;efficacy evaluation;efficacy testing;Elements;Energy Intake;Enrollment;Evaluation;experience;follow-up;food craving;Frequencies;Gastrectomy;Gastric Bypass;Health;Health Benefit;Hunger;Hypertension;improved;Individual;innovation;Instruction;Interruption;Intervention;Life Style Modification;Measures;Mediating;Medical;mindfulness;Morbid Obesity;negative affect;novel;novel strategies;obesity treatment;online delivery;online version;Operative Surgical Procedures;Outcome;Participant;patient engagement;patient population;Patients;Pattern;Persons;Physical activity;Physiological;pilot trial;post intervention;Postoperative Care;Postoperative Period;Procedures;programs;Randomized;Recommendation;Recurrence;remote delivery;Reporting;Research;response;Risk;secondary outcome;skills;Telephone;Testing;theories;Time;Treatment Efficacy;Weight;weight maintenance;Weight maintenance regimen;Work

PROJECT_TITLE: Evaluation of a Remotely-Delivered Behavioral Intervention for Post-Bariatric Surgery Weight Regain

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: The charitable food system, largely comprised of food banks and pantries, is a regular food source for up to 53 million people a year. The overall objective of this proposal is to use multi-level behavioral economics strategies to promote implementation of evidence-based interventions that will improve the dietary quality of food offered by pantries and selected and consumed by pantry clients. Results of this research will inform national and local hunger-relief organizations about the implementation of evidence-based nutrition interventions that can improve the diet and health of marginalized families at highest risk for obesity, diabetes, and cardiovascular diseases.

PI_NAMEs: LEVY, DOUGLAS ;THORNDIKE, ANNE N (contact)

PROGRAM_OFFICER_NAME: MASTERSON, MARY YAA SEDEGAH

PROJECT_TERMS: Adopted;Adoption;American;Architecture;behavior test;behavioral economics;Boston;budget impact;Cardiometabolic Disease;Cardiovascular Diseases;Carotenoids;Client;Cluster randomized trial;Collaborations;Consumption;cost effectiveness;Diabetes Mellitus;Diet;dietary;dietary guidelines;Dietary intake;Dietary Intervention;disorder risk;Dissemination and Implementation;Effectiveness;effectiveness/implementation study;Eligibility Determination;Equipment and supply inventories;evidence base;Evidence based intervention;Evidence based practice;experience;Family;feeding;Food;Food Assistance Programs;food consumption;food insecurity;Food Labeling;food quality;Food Selections;Health;Health Food;high risk;Household;Hunger;Hybrids;implementation barriers;implementation research;improved;Incentives;Intervention;Knowledge;Label;Light;Maintenance;marginalization;Measures;nutrition;Nutrition Labeling;obesity risk;Online Systems;Persons;Practical Robust Implementation and Sustainability Model;Privatization;programs;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Skin;social norm;Source;System;Testing;Time;tool;Waiting Lists;Workplace

PROJECT_TITLE: Behavioral economics to implement a traffic light nutrition ranking system in a network of food pantries

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CHICAGO

PROJECT_TERMS: Acceleration;Adult;Archives;Area;arm;authority;base;care systems;Caring;Chicago;Clinic;Clinical;Collaborations;Consultations;cost;data repository;data resource;data warehouse;Diabetes Mellitus;Diabetes prevention;Diagnosis;Disparity;Effectiveness;electronic health record system;Equity;ethnic minority;experience;Funding;Goals;Health;health care quality;health equity;health equity promotion;high risk population;improved;improved outcome;Infrastructure;interest;Intervention;Leadership;meetings;member;Midwestern United States;National Institute of Diabetes and Digestive and Kidney Diseases;Neighborhood Health Center;novel;Outcome;Paper;patient oriented;Patients;Peer Review;Policies;Population;Positioning Attribute;Poverty;Practice based research;Prevalence;prevention service;Preventive care;Primary Care;primary care clinic;Productivity;Protocols documentation;Public Health;Publications;racial minority;Research;Research Personnel;Research Support;Resources;secondary analysis;Seminal;Series;Services;Shoulder;Site;success;System;Translating;Translational Research;translational scientist;Uninsured;Vulnerable Populations;web site;webinar;Work

PROJECT_TITLE: National/Regional Resource Core: Accelerating Health Equity And Eliminating Diabetes Disparities in Community Health Centers (AHEAD-CHC)


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Precision Medicine

ORG_CITY: SALT LAKE CITY

ORG_NAME: GLYCOMIRA, LLC

ORG_STATE: UT

PHR: PROJECT NARRATIVE GlycoMira is developing a simple, minimally invasive, point-of-care test that can provide accurate diagnostic and prognostic information to healthcare providers and patients with eosinophilic chronic rhinosinusitis, a disease with an under-recognized burden on patient quality of life, clinical resources, and the healthcare economy. Patients with eCRS typically fail the standard of care and turn to costly surgical intervention and eosinophil- targeting biologic therapy to manage their disease. GlycoMira’s diagnostic test represents a promising objective measure by which to diagnose eosinophilic chronic rhinosinusitis, as well as to monitor patient response to medical and surgical treatment.

PI_NAMEs: PULSIPHER, ABIGAIL  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: accurate diagnosis;accurate diagnostics;Achievement;Affect;American;assay development;Basic Science;Biological Assay;Biological Response Modifier Therapy;Biological Sciences;Biopsy;candidate identification;Cells;chronic rhinosinusitis;Clinical;clinical diagnosis;clinical practice;cohort;commercialization;cost;cost effective;Cytolysis;Detection;detection assay;detection limit;Development;Diagnosis;Diagnostic;Diagnostic Reagent Kits;Diagnostic tests;Disease;Disease Progression;Economic Burden;Engineering;enzyme activity;eosinophil;eosinophil peroxidase;Eosinophilia;eosinophilic inflammation;Failure;Goals;Guidelines;health care economics;Health Personnel;healthcare burden;Human;Immunologic Markers;improved;Infiltration;Inflammatory;innovation;instrument;large scale production;Link;manufacture;Marketing;Measures;Mediator;Medical;Medical center;medical schools;meetings;Methods;minimally invasive;Modeling;Monitor;Nasal Polyps;nasal swab;Notification;novel diagnostics;observational cohort study;Observational Study;Operative Surgical Procedures;Pathologic;Pathology;Patient Monitoring;patient response;Patient-Focused Outcomes;Patients;Peripheral;Peroxidases;personalized medicine;Phase;Physiological;Pilot Projects;point of care;point of care testing;Predictive Value;Preparation;Process;prognostic;prospective;Quality of life;Resources;Sampling;Scientist;Seasons;Sinus;Slide;Specific qualifier value;Specificity;standard of care;Swab;Symptoms;targeted treatment;Testing;Therapeutic;Time;Tissues;tool;translational scientist;Treatment Failure;treatment response;Universities;Utah;validation studies

PROJECT_TITLE: Development of a Diagnostic Test for Eosinophilic Chronic Rhinosinusitis


NIH_SPENDING_CATS: Nutrition;Precision Medicine

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative This training program will help predoctoral and postdoctoral students to acquire skills to apply artificial intelligence techniques to big health data for precision nutrition. Success of this program will create a new generation of transdisciplinary nutrition and big data scientists who can extract new and actionable insights from voluminous and time-intensive data to personalize nutritional interventions to combat diet-related chronic diseases, obesity, diabetes, and fatty liver disease.

PI_NAMEs: LIU, LI ;WHISNER, CORRIE MARIE (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, VEERASAMY

PROJECT_TERMS: precision nutrition;System;Training

PROJECT_TITLE: Interdisciplinary Systems-based Training for Precision Nutrition


NIH_SPENDING_CATS: Clinical Research;Diabetes;Social Determinants of Health

ORG_CITY: CHICAGO

PI_NAMEs: BAIG, ARSHIYA AHMED (contact)

PROJECT_TERMS: Acceleration;Area;Award;base;Biological Sciences;career;Caring;Chicago;clinical practice;Collaborations;Communities;Community Health;community organizations;Data;design;Development;Diabetes Mellitus;Discipline;End stage renal failure;Engineering;Environmental Science;Equity;ethnic minority;Evidence based intervention;feasibility testing;Funding;Funding Mechanisms;Future;Generations;Geography;Goals;Grant;health equity;human centered design;improved;innovation;Institution;Intervention;Investments;medical schools;meetings;mobile phone based intervention;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;novel;Outcome;Patient Care;Private Sector;programs;Publications;racial minority;Research;Research Personnel;Research Support;Scientist;Secure;sedentary lifestyle;Sleep;success;Testing;Translating;Translational Research;translational scientist;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Universities;Vulnerable Populations;Woman;women of color;Work

PROJECT_TITLE: Pilot and Feasibility Program


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE An imbalance between caloric intake and output leads to excessive adipose tissue expansion and obesity, a major risk factor for the development of metabolic disease. Brown and beige adipocytes burn calories and have been considered possible therapeutic targets to fight obesity and metabolic disease also in humans. Here we propose to uncover novel mechanisms that govern adipose tissue function to ultimately devise novel therapeutic approaches to decrease metabolic dysfunction.

PI_NAMEs: MUELLER, ELISABETTA  (contact)

PROJECT_TERMS: Ablation;Adenosine;adipocyte biology;Adipocytes;Adipose tissue;ADORA2A gene;Affect;Aging;Animal Model;Biology;Calories;Cell secretion;Cells;Chromatin;chromatin remodeling;cofactor;combat;Conditioned Culture Media;Consumption;Cues;Data;Development;Disease;energy balance;Energy Intake;Epigenetic Process;Equilibrium;exosome;Expenditure;Fatty acid glycerol esters;fighting;Genes;Genetic Transcription;genome-wide;Health;Heat shock factor;Heat-Shock Response;histone demethylase;Homeostasis;HSF1;Human;innovation;insight;interest;Knockout Mice;Knowledge;Laboratories;Learning;Link;lipidomics;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Molecular;Molecular Target;Mus;new therapeutic target;next generation sequencing;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Nutrient availability;Nutritional;Obesity;Output;Pathologic;Pathway interactions;Physiological;Process;promoter;proteotoxicity;Publishing;Reagent;Regulation;response;Risk Factors;Role;Signal Transduction;Stimulus;Stress;Techniques;Technology;Temperature;therapeutic target;Thermogenesis;Time;Tissue Expansion;Tissues;tool;Transgenic Animals;treatment strategy;Work

PROJECT_TITLE: Novel mechanisms regulating adipose tissue function in health and disease


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Digestive Diseases;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Mounting evidence suggests that circulating extracellular vesicles and particles (EVPs) carry a variety of biological molecules and can serve as a reservoir of biomarkers for early cancer detection. In combination with our recently improved EVP isolation procedure and asymmetric-flow field-flow fractionation (AF4), we will further develop and validate the application of novel analytic technologies, including timsTOF 4D proteomic mass spectrometry, super-resolution dSTORM imaging analysis of single EVPs, and photocatalytic proximity labeling (µMap) technology for mapping protein-protein interactions, to discover and validate novel circulating EVP-borne biomarkers for early detection of pancreatic cancer.

PI_NAMEs: GERI, JACOB ;LYDEN, DAVID CHARLES (contact);ZHANG, HAIYING

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Age;analytical tool;Antibodies;bench-to-bedside translation;Biological;Biological Assay;Biological Markers;biomarker development;biomarker discovery;biomarker validation;cancer biomarkers;Cancer Detection;candidate identification;candidate marker;Categories;Cell Line;Cells;Circulation;cohort;Complex;Control Groups;Detection;Diagnosis;differential expression;Disease;early detection biomarkers;Early Diagnosis;Elasticity;Enrollment;Enzyme-Linked Immunosorbent Assay;exosome;extracellular vesicles;Field Flow Fractionation;flotillin;follow-up;Future;Image;Imaging technology;improved;Individual;ineffective therapies;Integrins;intercellular communication;ion mobility;Label;Linear Models;Lipids;liquid biopsy;Location;Malignant neoplasm of pancreas;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;Measures;Mediating;Medicine;Memorial Sloan-Kettering Cancer Center;Methods;MLLT2 gene;Modeling;Molecular Profiling;Monitor;nanoparticle;neoplastic cell;Newly Diagnosed;Normal Cell;novel;novel marker;Nucleic Acids;Pancreatic Adenocarcinoma;Pancreaticoduodenectomy;particle;Pathology;patient response;Patients;Performance;Peripheral;Physicians;Physiology;Plasma;potential biomarker;Procedures;protein biomarkers;protein protein interaction;Protein-Protein Interaction Map;Proteins;Proteome;Proteomics;Race;random forest;Reaction;Reproducibility;Research Personnel;Resolution;Resources;S100A12 gene;Sampling;Screening for cancer;Serum;sex;signature molecule;single molecule;specific biomarkers;Specimen;Spectrometry;Speed;superresolution imaging;superresolution microscopy;System;targeted treatment;Technology;Tenascin;therapy development;Time;tool;translational applications;Tumor Tissue;ultra high resolution;Ultracentrifugation;Western Blotting;Work

PROJECT_TITLE: Application of 4D proteomics and super-resolution microscopy in extracellular vesicle and particle-borne biomarker discovery for early pancreatic cancer detection

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Lung

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The goal of this work is to promote more comprehensive voice assessment in routine clinical practice through the introduction of accurate, low-cost respiratory and aerodynamic measures via a uniquely designed vortex whistle and accompanying signal analysis software. The vortex whistle system is optimized for measures of vital capacity and mean phonatory airflow from sustained phonation that are essential to the clinical evaluation of voice. An optimized vortex whistle system will be evaluated as a noninferior alternative to “gold” standard clinical instrumentation that is often inaccessible due to several constraints such as high cost and limited portability.

PI_NAMEs: AWAN, JORDAN ALEXANDER;AWAN, SHAHEEN  (contact);CHEN, JUN ;GILLESPIE, AMANDA I

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TITLE: Vital capacity & airflow measurement for voice evaluation: A vortex whistle system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-H(02)M]


NIH_SPENDING_CATS: Cost Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: LAITEERAPONG, NEDA  (contact)

PROJECT_TERMS: Acceleration;Area;Basic Science;Behavioral Research;Chicago;Cities;clinical investigation;Clinical Trials;Collaborations;Communities;community based participatory research;Complement;Cost Effectiveness Analysis;design;Diabetes Mellitus;Educational workshop;Elements;environmental enrichment for laboratory animals;Equity;Health;health disparity;health equity;improved;Incubators;innovation;Institution;Joints;Medicine;meetings;population health;programs;Public Health;Research;Research Infrastructure;Research Methodology;Research Personnel;Resources;Scientist;symposium;Translational Research;translational scientist;Translations;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE In primates, including humans, the central retina, especially the fovea, relies on the choroidal blood supply for metabolic and thermoregulatory support, but we know very little about the neuroanatomy or function of the autonomic pathways controlling primate choroidal blood flow. The proposed experiments constitute the first extensive and systematic investigation of the anatomy and physiology of the neural circuitry controlling the parasympathetic pathways supplying the choroidal vasculature of a primate. These results will set the stage for future studies in which this circuitry is modulated in order to improve the survival of central vision in models of macular degeneration.

PI_NAMEs: GAMLIN, PAUL DOUGLAS (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Affect;Age related macular degeneration;Anatomy;Angiography;Autonomic Pathways;Autopsy;Birds;Blood capillaries;Blood flow;Blood Pressure;Bruch's basal membrane structure;Cell Nucleus;Chemicals;Choroid;circadian;Compensation;Darkness;Diabetic Retinopathy;Disease;electrical microstimulation;Electrophysiology (science);Electroretinography;experimental study;Eye;Eye diseases;fovea centralis;Future;Ganglia;Goals;Health;Histology;Hour;Human;improved;inflammatory marker;Injections;Insulin-Dependent Diabetes Mellitus;intravitreal injection;Investigation;Label;Laser-Doppler Flowmetry;Lasers;Lesion;Life;Light;Lighting;Location;Long-Term Effects;luminance;macula;Macular degeneration;Magnetic Resonance Imaging;Measures;Mediating;melanopsin;Metabolic;Modeling;Motor;Motor Neurons;nerve supply;neural;neural circuit;Neuroanatomy;Neurons;neuroregulation;nonhuman primate;Nucleus solitarius;Optical Coherence Tomography;Parasympathetic Nervous System;paraventricular nucleus;Pathway interactions;Perfusion;pharmacologic;Photic Stimulation;Photoreceptors;Physiology;Primates;Rabies;Rabies virus;Reporting;response;Rest;Retina;Retinal Ganglion Cells;Rodent;Role;Serous;Structure of ciliary ganglion;Structure of retinal pigment epithelium;suprachiasmatic nucleus;Synapses;Thick;Time;Tracer;Vascular blood supply;Vertebrate Photoreceptors;Vision;Visual Fields;visual stimulus

PROJECT_TITLE: Neural Control of Choroidal Function

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]