NIH_SPENDING_CATS: Cancer;Cannabinoid Research;Clinical Research;Complementary and Integrative Health;Hematology;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Patient Safety;Rare Diseases;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative A significant proportion of patients with cancer are using medical cannabis, and limited data exists regarding the potential benefits and harms of this use during active treatment. This prospective study will provide information regarding cannabis use by patients with lung cancer and multiple myeloma including assessing the benefits and harms between cannabis users and non-users.

PI_NAMEs: CULLEN, JENNIFER ;LEE, RICHARD T (contact)

PROJECT_TERMS: abuse liability;active method;Address;Adjuvant;African American;American;Anxiety;Attention;Autologous Stem Cell Transplantation;Belief;Black race;Bortezomib;Cancer Patient;cancer therapy;cancer type;Cannabis;cannabis use behavior;chemotherapy;Clinics and Hospitals;cohort;Cohort Studies;Common Terminology Criteria for Adverse Events;Communication;Communities;Complex Variables;Computer software;Counseling;Data;Data Collection;demographics;Dexamethasone;Disease-Free Survival;Dose;Education;Ensure;Ethnic Origin;Gatekeeping;Goals;Health Personnel;Hematologic Neoplasms;Herb;Immune checkpoint inhibitor;Immunotherapy;Impaired cognition;inflammatory marker;instrument;Knowledge;Latino;Legal;lenalidomide;Malignant neoplasm of lung;Malignant Neoplasms;marijuana use;marijuana user;Medical;Medical Marijuana;Multiple Myeloma;National Health and Nutrition Examination Survey;Neoadjuvant Therapy;Newly Diagnosed;Nivolumab;Non-Small-Cell Lung Carcinoma;Oncologist;Oncology;Operative Surgical Procedures;Participant;patient population;Patients;Pattern;PD-1 inhibitors;Perception;Pharmaceutical Preparations;Phytotherapy;Platinum;Population;Positioning Attribute;Prevalence;Prospective Studies;Prospective, cohort study;Psychoses;Quality of life;Race;Recommendation;Reporting;Sampling;Schedule;side effect;Socioeconomic Factors;Solid Neoplasm;Standardization;Surveys;Symptoms;Therapeutic;treatment adherence;Treatment Protocols;Washington

PROJECT_TITLE: A Prospective Cohort Study of Patients with Non-Small Cell Lung Cancer and Multiple Myeloma to Assess the Benefits and Harms Related to Cannabis Use During Treatment


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT The overall aim of this project is to determine the efficacy of a smartphone application aimed at helping American Indians and Alaska Natives (AIANs) quit smoking. Positive results would improve health equity by providing a highly accessible and efficacious intervention for AIANs nationwide.

PI_NAMEs: BRICKER, JONATHAN B (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: 2 arm randomized control trial;Abstinence;Address;Adult;Advertisements;Alaska Native;American Indians;Behavioral;Biochemical;Cellular Phone;Cessation of life;Cigarette;cigarette smoke;cigarette smoking;Communities;community advisory board;comparative efficacy;Complex;cost;Data;digital;digital intervention;efficacious intervention;efficacy evaluation;efficacy testing;Enrollment;Ethnic Origin;Ethnic Population;experience;Family;Female;follow-up;Future;Geography;Goals;Group Therapy;health equity;health inequalities;Health Insurance;Healthcare Systems;Heart Diseases;Hospitals;improved;Income;Indian reservation;Individual;Industry;Inequity;Institutional Racism;Intervention;intervention program;Interview;Knowledge;long-standing disparities;male;Malignant neoplasm of lung;maltreatment;Mediating;member;Morphologic artifacts;National Cancer Institute;Northern Plains;Northern Plains Tribe;Outcome;Participant;Patient Self-Report;Persons;Pharmaceutical Preparations;Planet Earth;Play;Policies;Population;Prevalence;Process;Provider;public health relevance;Race;racial population;Randomized;Randomized, Controlled Trials;recruit;Research;Respiratory Disease;Ritual compulsion;rural area;Scientific Advances and Accomplishments;secondary analysis;sex;smartphone application;Smoke;Smoking;smoking cessation;Smoking Cessation Intervention;smoking cue;smoking prevalence;smoking-related cancer;social health determinants;Spirituality;Subgroup;System;Testing;theories;Time;Tobacco;Training;Trauma;treatment effect;trial comparing;United States

PROJECT_TITLE: Digital smoking cessation intervention for nationally-recruited American Indians and Alaska Natives: A full-scale randomized controlled trial

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: La Jolla

ORG_NAME: AMYDIS DIAGNOSTICS, INC.

ORG_STATE: CA

PHR: Project Narrative Alzheimer’s disease (AD), the most common form of dementia, is increasingly appreciated as a mechanistically heterogeneous condition in which variations in the accumulation of amyloid beta, alpha-synuclein and TDP-43 may define pathophysiologically distinct subsets of patients. Creating new diagnostic modalities to measure these biomarkers in CNS tissue is critical to developing novel, disease-modifying therapeutics for AD and applying them with precision in the AD population. The proposed study is the first clinical step in leveraging the eye as a “window to the brain” by advancing a novel retinal tracer that can image these biomarkers in retina for non-invasive, affordable and widely accessible diagnostic assessment of heterogeneity in the Alzheimer’s spectrum.

PI_NAMEs: SARRAF, STELLA  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: abeta accumulation;Address;Advanced Development;Age;alpha synuclein;ALS patients;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease therapeutic;Amyloid;Amyloid beta-Protein;analytical tool;Angiography;Artificial Intelligence;beta pleated sheet;Binding;Biological Markers;Blinded;Blood;Blood Vessels;Bolus Infusion;Brain;Cadaver;Caring;Categories;Characteristics;Clinical;clinical candidate;clinical diagnosis;clinical practice;Clinical Research;Clinical Trials;Cognitive;cognitive testing;cohort;commercial application;commercialization;Contrast Media;cost;Data;Databases;Dementia;Deposition;design;Detection;Development;Diagnostic;diagnostic technologies;Diagnostic tests;Dimensions;Disease;disease heterogeneity;Dose;Enrollment;Equilibrium;Equipment;Evaluation;Exhibits;Exposure to;Eye;familial Alzheimer disease;Fluorescence;fluorescence imaging;Foundations;Freeze Drying;Freezing;Functional disorder;Fundus;Future;Goals;Heterogeneity;high resolution imaging;Hippocampus;Human;hyperphosphorylated tau;Image;imaging biomarker;imaging modality;in vivo;Individual;individual patient;individualized medicine;Injections;knowledge integration;Label;Lead;Light;limbic-predominant age-related TDP-43 encephalopathy;Maps;Measures;Medical;Metabolic;Mission;Modality;multimodality;Mutation;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurofibrillary Tangles;neurofilament;novel;novel diagnostics;open label;ophthalmic examination;Optical Coherence Tomography;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;patient subsets;Patients;Pattern;Perfusion;PET positivity;Pharmaceutical Preparations;Phase Ib Clinical Trial;Physicians;Population;Positioning Attribute;Positron-Emission Tomography;precision medicine;Process;Property;protein biomarkers;protein TDP-43;Proteins;Radial;Radiation;Reading;reconstitution;recruit;Reporting;research clinical testing;Research Personnel;Retina;Retinal Diseases;retinal imaging;Safety;Senile Plaques;Signal Transduction;small molecule;Standardization;Structure;Symptoms;tau Proteins;tau-1;Technology;Testing;therapeutically effective;Tissues;Tracer;Variant;Vial device;Visit;Water

PROJECT_TITLE: Use of novel fluorescent tracers to develop a comprehensive retinal biomarker database that maps the heterogeneity of Alzheimer's pathogenesis


NIH_SPENDING_CATS: Aging;Bioengineering;Cardiovascular

ORG_CITY: SAN FRANCISCO

ORG_NAME: PICCOLO MEDICAL, INC.

PHR: Narrative Peripherally inserted central catheters (PICCs) are widely used to provide life-sustaining intravenous therapies, where placement navigation through the venous system is typically performed blind, or without navigation guidance. Commercially available navigation systems for peripherally inserted central catheters (PICCs) can be effective, but have limitations that have impeded adoption into the clinic. Piccolo Medical has developed the Smart PICC™ system, an inexpensive, easily operated catheter system for real-time vascular access guidance that addresses the limitations of current systems. In this Commercialization Readiness Pilot (CRP) project, we propose to refine our Smart PICC™ system such that it is designed for manufacturing and to submit a 510(k) application to the FDA.

PI_NAMEs: SHANAHAN, AUGUSTUS  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Address;Adopted;Adoption;Affect;Age;Algorithms;American;Area Under Curve;Arrhythmia;Award;biomaterial compatibility;blind;Blood Circulation;Blood Vessels;Cardiac;Catheters;Classification;Clinic;Clinical Research;commercial launch;commercialization;commercialization readiness;Computer software;Consensus;cost;cost effective;Critical Illness;Data;design;design verification;Detection;Devices;Direct Costs;Distal;EKG P Wave;Electrocardiogram;Electromagnetics;Excision;follow-up;Freezing;Funding;Future;Goals;hemodynamics;Hour;Human;improved;innovation;Intervention;Intravenous;Life;Location;machine learning algorithm;manufacture;Maps;Marketing;Measures;Medical;Navigation System;novel;Patients;Performance;Peripheral;Phase;Pilot Projects;Pneumothorax;point of care;Positioning Attribute;Price;Privatization;Procedures;Production;Quality of Care;Radiation exposure;radiologist;Real-Time Systems;Regional Anatomy;research and development;Right atrial structure;Risk;ROC Curve;Roentgen Rays;Safety;Sales;sensor;Serious Adverse Event;skills;Small Business Innovation Research Grant;Sterilization;success;Superior vena cava structure;System;Testing;Thoracic Radiography;Time;United States;usability;Venous system;verification and validation;Work

PROJECT_TITLE: A Novel, Low-Cost Device to Guide Peripherally Inserted Central Catheter (PICC) Line Placement


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This project evaluates the interactions between flooding, migration, and psychosocial health in coastal communities in the US, with a particular focus on the impacts of frequent, smaller floods caused by rising sea levels. Drawing on a combination of large-scale administrative records and a detailed representative household survey, I will quantify the relationship between residential migration and flood experience, examine how health, economic resources, and flood exposure interact to shape migration intentions, and evaluate the health and economic wellbeing of current residents of and recent out- migrants from areas exposed to sea level rise. The outcomes of this research will generate new empirical evidence on the impacts of coastal flooding on migration and psychosocial health and will enable the development of public policies and programs that address both chronic stresses imposed by rising sea levels and extreme events to better support communities at risk.

PI_NAMEs: HINO, MIYUKI  (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Acceleration;Acute;Address;Adult;adverse birth outcomes;Affect;Age;age group;Air Pollution;Area;Attitude;Behavior;career;Child;Chronic;Chronic stress;climate change;climate impact;climate-related exposures;Communities;community-level factor;Complex;County;Data;Data Set;Decision Making;design;Destinations;Development;Disasters;Drainage procedure;Economics;Education;Empirical Research;Environmental Exposure;Event;experience;Exposure to;extreme storms;extreme weather;Floods;Frequencies;Future;Genetic Complementation Test;Geography;Goals;Health;health assessment;Household;Human Development;Hurricane;Impairment;Improve Access;improved;Individual;insight;Measurement;Measures;Mentored Research Scientist Development Award;Mentors;Methods;Migrant;migration;Neighborhoods;North Carolina;novel;older adult;Out-Migrations;Outcomes Research;Personal Satisfaction;Persons;physical conditioning;population health;Population Sciences;Populations at Risk;Probability;programs;psychological distress;psychosocial;Public Policy;Rain;Recording of previous events;Records;Recurrence;Regression Analysis;Research;Research Personnel;Resolution;Resources;Respondent;response;Risk;Sampling;Sea;sea level rise;Shapes;skills;Stress;Survey Methodology;Surveys;System;Techniques;Testing;theories;Time;Training;United States;Vulnerable Populations;Water;Wildfire;young adult

PROJECT_TITLE: Evaluating the impacts of sea level rise on migration and wellbeing in coastal communities

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative The study will advance HIV science by showing the adaptability and preliminary efficacy of an HIV status-neutral intervention to reduce intersectional stigma and discrimination at the intrapersonal, interpersonal, and organizational levels. It will demonstrate ways to leverage assets such as GBSMSM+NURSES to build capacity, reduce stigma, and increase HIV testing, PrEP, and ART uptake among YGBMSM from resource-limited settings. The study will also show the feasibility of scaling up status-neutral intervention and implementing a clustered randomized control trial for YGBMSM and slum communities in Ghana, West Africa, and other stigmatized and marginalized communities, and its utility to continue to positively influence behavioral change among GBMSM across the lifespan and geographical setting.

PI_NAMEs: ABU-BA'ARE, GAMJI RABIU  (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Address;Adherence;Africa;Age;AIDS prevention;behavior influence;beneficiary;Bisexual;Caring;Clinical;Communities;community intervention;community partners;Consultations;Control Groups;Country;Data;design;Discrimination;Economics;Evaluation;experience;Face;Focus Groups;follow-up;Friends;Gays;gender expression;gender nonconforming;Geography;Ghana;group intervention;Health;Health care facility;Health Care Visit;high risk;high risk population;HIV;HIV Infections;HIV risk;HIV Seronegativity;Human immunodeficiency virus test;implementation outcomes;implementation strategy;improved;internalized stigma;Intervention;Interview;Knowledge;life span;Location;Manuals;marginalized community;Measures;men;men who have sex with men;Modeling;Multiple Partners;Nurses;Participant;Persons;poor communities;post intervention;pre-exposure prophylaxis;Prevalence;primary outcome;programs;Provider;Randomized;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Resource-limited setting;Risk;Same-sex;Sample Size;scale up;Science;Scientific Advances and Accomplishments;secondary outcome;self testing;Services;sex;Slum;social;social stigma;Stigmatization;Test Result;Testing;testing uptake;Training;transactional sex;treatment arm;Treatment Efficacy;uptake;Voice;Waiting Lists

PROJECT_TITLE: Status-neutral community-based multilevel intervention to address intersectional stigma and discrimination, and increase HIV testing, PrEP, and ART uptake among YGBMSM in Ghanaian Slums

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Precision Medicine;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Imaging biomarkers must be complex enough to represent the relevant features of aggressive breast cancers, but straightforward enough to be applicable at many sites for broad adoption. This project will target the balance of these two needs with a study of advanced imaging (intravoxel incoherent motion (IVIM)) at multiple sites in a cohort of breast cancer patients. The outcome of the study is expected to identify noninvasive imaging biomarkers that not only relate to tumor biology but can be broadly applied for prediction of response to pre- surgical (neoadjuvant) therapy, one of the crucial ingredients of breast cancer survival.

PI_NAMEs: SIGMUND, ERIC EDWARD (contact);THAKUR, SUNITHA BAI

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: 3-Dimensional;Address;Adjuvant Chemotherapy;Adopted;Adoption;Affect;aggressive breast cancer;Algorithms;angiogenesis;Apoptosis;Binding Sites;Biological Markers;biomarker identification;biophysical model;Blood;Blood Vessels;Breast Cancer Patient;breast cancer survival;cancer care;cancer imaging;Cellularity;Clinical;Clinical Data;clinical implementation;clinically relevant;cohort;Collaborations;Communities;Complex;Computer software;Data;design;Diagnostic;diagnostic value;Diffusion;Diffusion Magnetic Resonance Imaging;digital;digital repositories;Early treatment;Environment;Equilibrium;Explosion;Future;Generations;Goals;Health;Heterogeneity;Image;imaging biomarker;imaging modality;improved;individual patient;innovation;insight;Institution;International;Literature;Longitudinal Studies;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Methods;Modeling;molecular subtypes;Motion;Necrosis;Neoadjuvant Therapy;non-invasive imaging;Olea;open source;Outcome Study;Pathologic;Patients;Performance;Phase;potential biomarker;predicting response;Prediction of Response to Therapy;predictive marker;prognostic;prognostic value;prospective;Protocols documentation;prototype;quantitative imaging;recruit;Reproducibility;Research;response;Site;Statistical Data Interpretation;success;synergism;System;targeted treatment;Techniques;Technology;Testing;Therapy trial;Time;Tissues;tool;Toxic effect;Translating;translational potential;Translations;treatment and outcome;treatment response;tumor;Tumor Biology;tumor heterogeneity;Tumor Markers;tumor microenvironment;Tumor Volume;Validation;Variant;Vascular Permeabilities;Vendor

PROJECT_TITLE: Breast Cancer Intravoxel-incoherent-motion MRI Multisite (BRIMM) Study - Resubmission - 1


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Substance Misuse

ORG_CITY: GOLDEN

ORG_NAME: KLEIN BUENDEL, INC.

ORG_STATE: CO

PHR: The new recreational marijuana markets are contributing to polysubstance-impaired driving and other harms, especially when marijuana is used in combination with alcohol, by selling marijuana to obviously-intoxicated customers. In this study, the effectiveness of an intervention to reduce the risk of marijuana sales to obviously- intoxicated customers will be tested in the state-licensed recreational marijuana market in Oregon, one of the first states to ban such sales. The intervention will combine efforts by state regulators to increase deterrence of the state law prohibiting marijuana sales to obviously-intoxicated customers with training of store personnel to recognize signs of intoxication and refuse sales.

PI_NAMEs: BULLER, DAVID B;WOODALL, W GILL (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Adherence;Alaska;alcohol services;Alcoholic Intoxication;Alcohols;Area;Automobile Driving;Awareness;Biometry;Blood;Cannabis retail;Chicago;comparison group;Consumption;County;Crossover Design;design;Disputes;distilled alcoholic beverage;Doctor of Philosophy;driving skills;Educational Intervention;Effectiveness of Interventions;effectiveness testing;Evaluation;Face;falls;field sobriety tests;Funding;Gills;Goals;high risk;Human Resources;impaired driving performance;Impairment;improved;Impulsive Behavior;Injury;innovation;Intervention;Intoxication;Laws;Legal;Letters;Licensing;Marijuana;marijuana use;Marketing;metropolitan;Modeling;Morbidity - disease rate;mortality;Motivation;National Institute of Drug Abuse;Oregon;Outcome Study;Persons;Policies;Policy Research;prevent;Prevention;Prevention approach;Principal Investigator;Protocols documentation;Randomized;Randomized, Controlled Trials;Recreation;Regulation;Reporting;Reproducibility;Research;Research Institute;Research Personnel;Risk;risk perception;Risk Reduction;Sales;skills;social;Testing;Training;uptake;Vehicle crash;vehicular accident;Vendor;Violence;Washington;Work

PROJECT_TITLE: Policy and Training Intervention in Responsible Marijuana Sales Practices to Reduce the Risk of Selling to Intoxicated Customers


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Black/African American (Black) young adults have among the highest prevalence of cigarillo smoking. Although cigarillo smoking is associated with multiple cancers and pulmonary and cardiovascular diseases, some Black young adults’ have low harm perceptions associated with their uptake and escalation of cigarillo use. This project will address gaps on how to effectively communicate the harms of cigarillos to Black young adults to inform FDA’s communications research priority, and ultimately reduce racial disparities in cigarillo smoking affecting Black young adults.

PI_NAMEs: PHAN, LILIANNA  (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: addiction liability;Address;Adult;Affect;African American;Age;age group;authority;Award;base;Behavior;Behavior Control;Black race;Carcinogens;Cardiovascular Diseases;career;Cigar;Cigar Smoking;Cigarette;cigarette smoking;cigarillos;Communication;Communities;critical developmental period;Data;design;Disparity;Effectiveness;efficacy testing;Emotions;ethnic minority;Ethnic Population;Expectancy;experimental study;follow-up;Goals;Health;health communication;health disparity;health equity;High Prevalence;Inhalation;Intervention;Lung Diseases;Malignant Neoplasms;Measures;Mentors;Outcome;Participant;Patient Self-Report;Perception;Phase;pilot test;Positioning Attribute;Predisposition;prevent;primary outcome;public education;racial disparity;racial minority;racial population;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;reduce tobacco use;Relaxation;Research;Research Personnel;Research Priority;Risk;secondary outcome;Smoking;smoking prevalence;Social status;sound;Testing;Tobacco;tobacco prevention;tobacco products;tobacco regulatory science;Tobacco use;Training;United States Food and Drug Administration;uptake;Visual attention;visual tracking;Vulnerable Populations;young adult

PROJECT_TITLE: Effective Cigarillo Public Education Messaging for Black Young Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-K(90)S]


ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE  The zebrafish is well established and accepted as a scientific model system for studying vertebrate development and as a model to study human disease and disorders, including alcohol and drug abuse, cancer, infectious disease, and neurodegeneration. The long-standing Strategic Conference of Zebrafish Investigators (SCZI) brings principal investigators from all scientific disciplines together to exchange ideas, share new methodologies, form collaborations, foster resource development, and draw strategic plans for the optimal use of the zebrafish model in basic and biomedical research. This proposal seeks support for five future SCZI conferences as a successful annual series to allow principal investigators to strategically discuss current research, approaches, and challenges, to integrate new members of the zebrafish community, and to promote coordinated advancement of research using the zebrafish model system.

PI_NAMEs: MOSIMANN, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Adopted;Aging;Alcohol abuse;Asia;Basic Science;Biological Models;Biomedical Research;Canada;Carbon;career;cell type;Cementation;Chemicals;Child Care;clinical development;clinically relevant;Collaborations;Communicable Diseases;Communities;COVID-19 pandemic;Development;Developmental Process;Discipline;Disease;diversity and inclusion;Drug abuse;Ensure;Environment;Equilibrium;Europe;European;Event;Female;Financial Support;forward genetics;Fostering;Funding Mechanisms;Future;Gender;Gene Transfer Techniques;Genes;genetic analysis;genome editing;Genomic approach;Goals;Grant;Guidelines;high resolution imaging;human disease;human model;Image;Imaging Techniques;International;Laboratories;Learning;Life;Location;Malignant Neoplasms;meetings;member;Mentors;Methodology;Methods;Minority;model organism;Modeling;mutant;Natural regeneration;Nerve Degeneration;optogenetics;Organism;originality;Paper;Participant;Personal Growth;Persons;Phenotype;Physiology;Principal Investigator;Race;Rapid screening;Reagent;Research;Research Personnel;Resource Development;reverse genetics;Rotation;Schedule;Science;Scientist;screening;Series;single cell genomics;Societies;Solid;Strategic Planning;Structure;symposium;System;Techniques;Therapeutic;Time;Toxic Environmental Substances;Toxin;Travel;Variant;Woman;Writing;Zebrafish

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Pediatric;Physical Activity;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: MoTrPAC Narrative While there are many important health benefits of physical activity, how exercise exerts its effects is not fully understood. A more comprehensive understanding of the molecular mechanisms underlying the responses to exercise would significantly impact public health. Continuation of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) will achieve its objective of generating a comprehensive map of the molecular responses to acute exercise and exercise training, with a long-range goal of elucidating the mechanisms by which exercise improves health.

PI_NAMEs: MUSI, NICOLAS  (contact);RASMUSSEN, BLAKE B

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 17 year old;18 year old;Acceleration;Acute;Adipose tissue;Adult;Age;age group;Age Years;Ancillary Study;Animals;Attention;Award;Bioinformatics;Biological Process;Blood;California;Categories;Charge;Chemicals;Child;Childhood;Chronic;Clinical;clinical center;Clinical Protocols;Clinical Research;Clinical Trials Data Monitoring Committees;cohort;Collaborations;Collection;Communication;Communities;COVID-19;COVID-19 pandemic;Data;design;Development;Disease;Disease Outcome;endurance exercise;Enrollment;Ensure;ethnic minority;Exercise;exercise intervention;exercise training;falls;follow-up;Frequencies;Funding;Gender;Goals;Health;Health Benefit;Heterogeneity;Human;improved;Individual;innovation;insight;Institutional Review Boards;Intervention;Joints;Los Angeles;Manuals;Manuscripts;Maps;Measurement;Medical center;men;Minority Groups;Molecular;Multi-site clinical study;multiple omics;Muscle;novel;Observational Study;operation;pandemic disease;Participant;Pathway interactions;Pediatric cohort;Phase;Phenotype;phenotypic data;Physical activity;Physiological;pre-clinical;Procedures;programs;Protocols documentation;public database;Public Health;quality assurance;Race;racial minority;Randomized;Randomized, Controlled Trials;recruit;Recruitment Activity;Research;Research Activity;Research Personnel;Resistance;resistance exercise;Resources;response;Rest;sedentary;sex;Site;Suspensions;Testing;Time;Tissues;Training;Training Programs;Transducers;United States National Institutes of Health;Universities;Visit;Woman;working group;Youth

PROJECT_TITLE: Molecular Transducers of Physical Activity Consortium Adult Clinical Center


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_CITY: WARSAW

ORG_NAME: ECLIPSE ORTHOPAEDICS, LLC

ORG_STATE: IN

PHR: Narrative A common and successful treatment for long bone fractures is the implantation of a stiff metal rod, or intramedullary (IM) nail, through the center of the bone which is then fixed to the bone with screws. To anchor the nail securely, the surgeon must accurately drill pilot holes through both the bone and locking holes in the nail, while the nail is hidden from view. This challenging task and often results in longer surgery time, additional blood loss and radiation exposure and a risk of malrotation of the extremity. In this SBIR, Eclipse Orthopaedics will develop a device to significantly improve the freehand targeting of IM nails based on Eclipse’s patented technology.

PI_NAMEs: RICH, DAVID BOYD (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: Affect;Agreement;arm;Bite;bone;Cadaver;Capital;Certification;Clinical Trials;Collaborations;commercialization;Communities;Computers;Consumption;Data;design;design verification;Development;Device Designs;Devices;Distal;Effectiveness;Engineering;Evaluation;experience;Feasibility Studies;Feedback;Femur;Fluoroscopy;Fracture;General Practitioners;Goals;Hand;Health;Hemorrhage;Hip Fractures;Human;Image;imager;Implant;implantation;improved;Indiana;Industry;innovation;Innovation Corps;insight;interest;Interview;Intramedullary Nailing;Knowledge;Learning;Leg;Legal patent;Licensing;Limb structure;long bone;Manufacturer;Marketing;Measurable;Measures;Medical;Medical Device;Medical Device Designs;Metals;Methods;Modeling;Nail plate;Operating Rooms;operation;Operative Surgical Procedures;Orthopedic Procedures;Orthopedics;Patient-Focused Outcomes;Patients;Performance;Phase;Preparation;Procedures;product development;programs;Protocols documentation;prototype;Qualifying;Radiation;Radiation Dose Unit;Radiation exposure;radiological imaging;Regulatory Pathway;response;Risk;Rod;Roentgen Rays;Safety;sample fixation;Schedule;Secure;Site;Small Business Innovation Research Grant;Source;Surgeon;System;Technology;Testing;tibia;Time;tool;Trauma;trauma centers;trauma surgery;United States National Institutes of Health;usability;Veterans;wireless;Work

PROJECT_TITLE: Fluoroscopic drill attachment for orthopedic trauma surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-W(12)B]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Health Services;Prevention

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative: In Training for Health Professionals (THP-1), we demonstrated that a sexual health curriculum tailored to the challenges in Africa is effective short-term in training students in sexual health. In THP-2, we will study the medium to long-term effects, pilot a program to train faculty to deliver the curriculum, and then study if the curriculum produces the same results in “real world” conditions as it did in the rigorously controlled study. Successful completion of this grant will provide us with the evidence and tools needed to disseminate this intervention across Tanzania, to other parts of Africa, and to other LMICs.

PI_NAMEs: MKOKA, DICKSON ALLY;ROSSER, B R SIMON  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adopted;Adoption;Africa;Africa South of the Sahara;African;Ally;arm;Attitude;Behavior;blind;Caring;Clinical Skills;Communities;comparison control;Controlled Study;Counseling;Country;Development;Discipline of Nursing;early pregnancy;Education;Educational Curriculum;Educational process of instructing;Effectiveness;effectiveness evaluation;Environment;Erectile dysfunction;Evaluation;evaluation/testing;Faculty;Focus Groups;follow-up;Grant;Health;health care delivery;health communication;health knowledge;Health Personnel;Health Professional;Health Services;health training;Healthcare;HIV;HIV/STD;improved;Individual;Intervention;intervention effect;Interview;Knowledge;Laws;Lesbian Gay Bisexual Transgender;Long-Term Effects;Longterm Follow-up;low and middle-income countries;male;Manuscripts;Measures;Medical;medical schools;Medical Students;Midwife;Midwifery;Morbidity - disease rate;mortality;Needs Assessment;Nurses;Observational Study;Outcome;Paper;Participant;Patients;Peer Review;Persons;Phase;phase III trial;phase IV trial;Population;post intervention;Privatization;Productivity;programs;Provider;provider behavior;Randomized;Randomized, Controlled Trials;Recording of previous events;Reporting;Reproductive Health;Research;Resources;routine care;Schools;Science;Self Assessment;sexual and reproductive health;Sexual Health;sexual violence;Single-Blind Study;single-blind trial;Site;skill acquisition;skills;Standardization;student training;Students;Surveys;Tanzania;Teacher Professional Development;Teenagers;Testing;tool;Trainers Training;Training;transmission process;treatment arm;unintended pregnancy;Universities;Waiting Lists

PROJECT_TITLE: Evaluating the effects of reproductive health training on provider behavior

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: DAVIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Neurodevelopmental disorders and conditions are common in the population, representing a significant burden in all aspects of life and society. Many variants and genes are still left undiscovered and may reside within complex parts of the human genome. Studies aimed at identifying underlying genetic causes and mechanisms of these disorders will lead to a better understanding of the underlying biological mechanisms.

PI_NAMEs: DENNIS, MEGAN Y (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: autism spectrum disorder;autistic children;axon guidance;Benchmarking;Bioinformatics;bioinformatics pipeline;Biological;Biological Assay;Biological Models;Brain;Candidate Disease Gene;causal variant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complex;Copy Number Polymorphism;Coupled;Data;Data Set;Development;Developmental Process;Disease;Embryo;Etiology;Evolution;Exhibits;experience;Eye Development;falls;Family;fetal;frontier;functional genomics;gene conservation;Gene Duplication;gene function;Genes;Genetic;Genetic Diseases;Genetic Heterogeneity;Genetic Risk;Genetic Screening;genetic variant;Genetic Variation;Genome;genomic locus;Genomics;Human;Human Genetics;Human Genome;human pangenome;human reference genome;Image;improved;individuals with autism spectrum disorder;innovation;insight;Knock-out;Left;Life;Location;Maps;Messenger RNA;Methods;Modeling;Modernization;Morphology;Mus;mutant;Mutation;neural;neurodevelopment;Neurodevelopmental Disorder;Neurologic;Neurons;Orthologous Gene;paralogous gene;patient screening;Phenotype;Pongidae;Population;Population Control;Primates;proband;Proliferating;Proteins;Publications;Publishing;rare variant;Recurrence;reference genome;Role;Sampling;Sequence Analysis;Siblings;Signal Transduction;single-cell RNA sequencing;Societies;Source;Specific qualifier value;SRGAP2 gene;synaptic function;synaptogenesis;telomere;Testing;Time;tool;trait;transcriptome sequencing;Variant;whole genome;Zebrafish

PROJECT_TITLE: Human gene duplications in neurodevelopment and disease

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Stroke

ORG_CITY: DURHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative This project seeks to understand the neural and functional basis of verbal working memory (vWM) for speech production. The dysfunction of vWM has been implicated in both stroke related and developmental language disorders. Understanding the neural and functional basis of verbal working memory for speech production would greatly advance the knowledge of how memory processes support language in the brain, in the hopes that this will lead to more targeted rehabilitation from stroke, better surgical approaches to language mapping, and insight into new therapeutic strategies for speech and language disorders.

PI_NAMEs: COGAN, GREGORY B (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TITLE: The overlap of speech production and verbal working memory

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative  Statistical methods such as those to be developed in this research help medical researchers discover and validate new basic science results—for example in genomics, immunology and fundamental biology— that can lead to new therapies. They aid also in the planning and analysis of clinical investigations of new treatments so as to use in the most efficient manner the large amount of data collected in current research, while also accurately describing the degree of uncertainty in the conclusions.

PI_NAMEs: JOHNSTONE, IAIN M (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: algorithm development;Algorithms;Awareness;Basic Science;Binding;biobank;Biology;Biopsy;Cells;clinical investigation;Collection;Computational Biology;Computer software;Data;Data Analyses;Development;Disadvantaged;Disease;Disparate;DNA Sequence;EEG-based imaging;Evolution;Exhibits;experience;Gene Expression;Genetic;genetic analysis;Genetic Variation;genome wide association study;Genomics;Goals;Grant;Height;high dimensionality;Human;Image;Immune;Immunology;Individual;innovation;interest;Label;large datasets;Lasso;Lead;Learning;learning strategy;Linkage Disequilibrium;magnetic resonance imaging/electroencephalography;Mass Spectrum Analysis;Measures;Medical;Medicine;Methods;Modeling;multidimensional data;Names;novel strategies;novel therapeutics;Outcome;Patients;Pattern;Persons;phenome;Phenotype;pleiotropism;population health;Protein Array;Reporting;Research;Research Personnel;Signal Transduction;simulation;Statistical Methods;Statistical Models;Statistical Study;statistics;Structure;Students;supervised learning;Techniques;Testing;theories;Tissues;tool;trait;transcriptome sequencing;Trees;Uncertainty;Validation;Viral

PROJECT_TITLE: New Statistical Methods for Medical Signals and Images

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Services;Liver Disease;Networking and Information Technology R&D (NITRD);Rural Health;Substance Misuse;Telehealth

ORG_CITY: MADISON

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Rising rates of alcohol-associated liver disease are a public health emergency in the United States, and though alcohol cessation saves patients’ lives, few patients have access to evidence-based alcohol interventions. Smartphone applications hold potential to improve outcomes for patients with alcohol-associated liver disease by overcoming barriers to evidence-based alcohol treatment. The investigators will perform a randomized controlled trial testing the effect of a proven smartphone application for alcohol cessation (called CHESS Health Connections app) on alcohol cessation among patients with alcohol-associated liver disease at two medical centers in Michigan and Wisconsin.

PI_NAMEs: BROWN, RANDALL T;MELLINGER, JESSICA LEIGH;QUANBECK, ANDREW  (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Abstinence;Address;Adoption;Age;alcohol abstinence;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol intervention;alcohol testing;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Anxiety;behavior change;Behavior Therapy;Behavioral;Blood Tests;Caring;Cessation of life;Chronic;Cirrhosis;Clinic;Collaborations;compare effectiveness;Competence;Computerized Medical Record;cost comparison;Cost Effectiveness Analysis;Cost Measures;Counseling;COVID-19 pandemic;Critical Care;Data;Decision Making;Diagnosis;Diagnostic;digital health;Disease;Effectiveness;effectiveness evaluation;effectiveness trial;effectiveness/implementation trial;end stage liver disease;Engineering;Enrollment;evidence base;Goals;Health;Health Care Costs;Health Sciences;Health Services Accessibility;Healthcare;Heavy Drinking;Hepatology;high risk drinking;Hybrids;Impairment;implementation cost;implementation evaluation;implementation science;improved;improved outcome;innovation;Intervention;intervention effect;Interview;Liver;Liver diseases;liver transplantation;Measurement;Measures;Mediator;Medical;Medical center;Medical Research;men;Mental Depression;Mental Health;mHealth;mhealth interventions;Michigan;Mobile Health Application;Modeling;Monitor;Morbidity - disease rate;mortality;Motivation;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;pandemic disease;Patient Care;patient engagement;patient population;Patient-Focused Outcomes;Patients;peer support;Persons;Pharmacotherapy;Population;primary outcome;Prognosis;Provider;public health emergency;Quality-Adjusted Life Years;Randomized;randomized, clinical trials;Randomized, Controlled Trials;reduced alcohol use;Replicating Effective Programs;Research;Research Personnel;Resources;rurality;Self Management;sex;Sleeplessness;smartphone application;Sodium;Specialist;standard of care;stem;Strategic Planning;Substance abuse problem;Substance Use Disorder;System;tertiary care;Testing;treatment as usual;treatment comparison;trend;United States;Universities;Wisconsin;Woman;Women's mortality;Work

PROJECT_TITLE: Testing an mHealth System for Integrating Alcohol Use Treatment with Hepatology Care for Patients with Alcohol-associated Liver Disease


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE The goals of this proposal are (1) to develop and validate a method in both mice and rats for analyzing a molecule’s ability to cross an intact blood-testis barrier (BTB), and; (2) identify new chemical scaffolds or structures that are able to cross or confer ability to cross the BTB.

PI_NAMEs: WONG, HENRY L (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Age;analog;Antispermatogenic Agents;Biological Availability;Biological Process;Blood;Blood-Testis Barrier;Chemical Structure;Chemicals;Circulation;Collection;Communicable Diseases;Contraceptive Agents;Contraceptive methods;Data;design;Development;Drug Design;drug discovery;Drug Targeting;drug testing;Effectiveness;efficacy testing;Elements;Epithelium;Family Planning;Fertility;Genetic;Goals;Health;Healthcare;HIV;Human;Hybrids;Immune;Immunity;improved;inhibitor;Institution;Integration Host Factors;Ligation;Liquid substance;macromolecule;male;Male Contraceptive Agents;male fertility;Malignant Neoplasms;Measures;Methods;Modeling;Molecular;Molecular Target;Mus;mutant;novel;Parasites;pathogen;Pathogenicity;Pathway interactions;Penetration;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Physiological;Plasma;Procedures;programs;rational design;Rattus;Reference Standards;Research;Research Design;Research Personnel;Resources;retinoic acid receptor alpha;Risk;Rodent;Sampling;scaffold;Seminiferous tubule structure;Series;sertoli cell;Site;small molecule;solute;sperm cell;Spermatids;Spermatocytes;spermatogenic epithelium structure;Standardization;Structure;Structure of efferent ductule of testis;Subcellular Anatomy;success;System;Techniques;Testing;Testis;Therapeutic;therapeutic target;Tight Junctions;Tissue Sample;Tissues;tool;Trypanosoma;Validation;Virus Diseases;Xenobiotics;ZIKA

PROJECT_TITLE: Development/Validation of Rete Testis Microcannulation for the Assessment of Novel Chemical Scaffolds That Penetrate the Blood Testis Barrier

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Despite the success of interventions for increasing physical activity among cancer survivors, many survivors return to inactive or insufficiently active behaviors after the intervention ends. To facilitate long-term maintenance of physical activity, we propose to test an adaptive intervention approach, which allocates additional support and resources to those who are having difficulty maintaining physical activity following the completion of an exercise program. The results from this study will inform the development and implementation of strategies to help cancer survivors maintain sufficient levels of physical activity.

PI_NAMEs: LEACH, HEATHER JEAN (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: active lifestyle;adaptive intervention;Address;Adopted;Aerobic Exercise;Agreement;Behavior;behavior change;cancer diagnosis;Cancer Intervention;Cancer Survivor;cancer therapy;Classification;Clinic;Communities;community partners;Community Practice;Data;Development;Enrollment;evidence base;Exercise;exercise intervention;exercise program;fitness;Focus Groups;follow-up;Goals;Guidelines;Health;improved;Individual;Intervention;intervention delivery;Interview;Leisures;Location;Maintenance;Malignant Neoplasms;Manuals;Measures;Modality;Modeling;moderate-to-vigorous physical activity;mortality;Needs Assessment;Outcome;Participant;Partnership Practice;personalized approach;Phase;Physical activity;pilot trial;primary outcome;Procedures;programs;Protocols documentation;psychosocial;Public Health;Randomized;Recommendation;Research;resistance exercise;Resources;response;Sequential Multiple Assignment Randomized Trial;Site;social cognitive theory;Structure;Subgroup;success;Surveys;Survivors;Testing;theories;therapy design;Time;Training;videoconference

PROJECT_TITLE: An adaptive physical activity maintenance intervention for cancer survivors

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Immunotherapy;Neurodegenerative;Neurosciences

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: One of the primordial reasons why Alzheimer’s remains undertreated is that current pharmacological treatments of neurological and neurodegenerative diseases are severely limited. For the purpose of this study, we will apply focused ultrasound for opening of the blood-brain barrier that could have beneficial cognitive improvements towards the effective treatment of Alzheimer’s disease.

PI_NAMEs: KONOFAGOU, ELISA E. (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: 3-Dimensional;3xTg-AD mouse;Aftercare;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Area;Astrocytes;asymptomatic Alzheimer's disease;Behavioral;Blood - brain barrier anatomy;Blood Tests;Brain;Central Nervous System Diseases;Clinical;clinical practice;clinical translation;Clinical Trials;Code;Cognition;Cognitive;Cognitive deficits;cohort;cost efficient;COVID-19 pandemic;density;Dependence;Drug Delivery Systems;effective therapy;Engineering;Episodic memory;Focused Ultrasound;Funding;Health Care Costs;Hippocampus;Human;Immune;immune activation;Immune response;Immunotherapeutic agent;Immunotherapy;improved;Infrastructure;Journals;Link;Longitudinal Studies;Macrophage;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Maps;Mediating;medical specialties;Memory;Memory impairment;Microbubbles;Microglia;model development;Monitor;mouse model;multidisciplinary;Mus;National Institute on Aging;Nervous System Disorder;Neurodegenerative Disorders;neuroimmunology;Neurology;Neuronavigation;neuroprotection;Neurosciences;nonhuman primate;Onset of illness;Outcome;Pathology;patient safety;Peer Review;Peripheral;pharmacologic;Pharmacological Treatment;Phenotype;Positron-Emission Tomography;Prefrontal Cortex;Primates;Progress Reports;Publications;recruit;Reporting;response;sex;Short-Term Memory;simulation;Site;Synapses;System;tau Proteins;Techniques;Technology;Testing;Therapeutic;Therapeutic Effect;Time;timeline;transcriptomics;Translating;Translations;ultrasound

PROJECT_TITLE: Assessment of ultrasound-facilitated neurotherapeutics in Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: CORTE MADERA

ORG_NAME: OPHIREX, INC.

PHR: Project Narrative Each year in the United States, an estimated 10,000 individuals are bitten by venomous snakes, resulting in severe pain, disability, and occasionally death. There is an urgent need for effective treatments to prevent disability and death from snakebite in the U.S. and abroad, where more than 500,000 people are killed or disabled each year. Ophirex is a Public Benefit Corporation developing new intravenous and oral treatments for snakebite using a potent venom antidote called "varespladib" that blocks a key toxin found in more than 95% of snake venoms worldwide--and thought to be present in 100% of venomous snakes native to the United States.

PI_NAMEs: CARTER, REBECCA WONDER;LEWIN, MATTHEW ROBERT;PLATTS-MILLS, TIM  (contact)

PROGRAM_OFFICER_NAME: NUGENT, BRIDGET

PROJECT_TITLE: Development of Intravenous Varespladib, a Phospholipase A2 Inhibitor, for the Treatment of Snakebite Envenoming


NIH_SPENDING_CATS: Aging;Nutrition

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Dietary restriction (DR) is a potent and evolutionarily conserved intervention to ameliorate age-dependent disease and extend healthy lifespan. This proposal aims to elucidate new mechanisms of DR-mediated protection by determining how DR remodels the intracellular architecture to optimize inter-organelle interactions and metabolic efficiency. Understanding the mechanisms behind this structural remodeling will provide new therapeutic avenues in combating age-onset diseases.

PI_NAMEs: ARROJO E DRIGO, RAFAEL ;BURKEWITZ, KRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Age of Onset;age related;age-related disease;aged;Aging;animal old age;Animals;Architecture;Autophagocytosis;biological adaptation to stress;birth control;Caenorhabditis elegans;Cell Aging;Cell Physiology;Cells;Cellular biology;Chronic;Communication;Complement;Data;deep learning;Defect;Deterioration;dietary restriction;Electron Microscopy;Endoplasmic Reticulum;endoplasmic reticulum stress;Endosomes;Event;experimental study;fitness;Fluorescence Microscopy;functional decline;Functional disorder;Glucose;Goals;healthspan;healthy aging;Hepatocyte;Homeostasis;Image;imaging approach;Imaging technology;In Situ;in vivo;insight;Intervention;Isotope Labeling;Isotopes;Label;Link;Lipids;Logic;Longevity;Macronutrients Nutrition;Maintenance;Maps;Mediating;Metabolic;Metabolism;microscopic imaging;Mitochondria;Modeling;Molecular;Morphology;mouse model;Mus;novel therapeutics;Nutrient;nutrient metabolism;Onset of illness;Organelles;Pattern;Performance;peroxisome;Physiologic pulse;Play;Proteins;resilience;Resolution;Resources;response;Role;Route;Series;Shapes;Site;spatial relationship;stable isotope;Stress;Structure;Subcellular structure;trafficking;uptake

PROJECT_TITLE: Interrogation of the cellular and subcellular architecture of nutrient metabolism in conditions of dietary restriction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rare Diseases

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE This application is to develop a robust, non-invasive, easy to access saliva test that is able to detect head and neck cancer recurrence in a timely and cost-effective way. Success in meeting the objective will enable its clinical utility into current clinical practice as a Laboratory Developed Test.

PI_NAMEs: LU, SHI-LONG  (contact)

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Algorithms;Applications Grants;Biological Assay;biomarker development;biomarker panel;cancer biomarkers;Cancer Detection;cancer recurrence;Clinical;clinical application;clinical practice;Clinical Practice Guideline;Clinical Research;clinical translation;cohort;cost effective;Detection;detection method;Development;Distant;Early Diagnosis;experimental study;Follow-Up Studies;Future;genomic locus;Goals;Head and Neck Cancer;Head and Neck Neoplasms;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Health Care Costs;improved;Incidence;Institution;Intervention;Laboratories;Larynx;Magnetic Resonance Imaging;Malignant Neoplasms;Medical;Medical Imaging;meetings;Methods;Methylation;microRNA biomarkers;MicroRNAs;National Comprehensive Cancer Network;Nature;Observational Study;Operative Surgical Procedures;Oral cavity;Outcome;patient population;Patients;Performance;Periodicals;PET/CT scan;Pharyngeal structure;Phase;preclinical study;prediction algorithm;Prevalence;prospective;Prospective Studies;Publishing;Radiation exposure;Radiation therapy;random forest;Recommendation;Recurrence;Reproducibility;Research;Resource-limited setting;Roentgen Rays;rural area;Saliva;saliva analysis;saliva sample;salivary assay;screening;Screening for cancer;Specificity;Squamous cell carcinoma;success;System;Testing;testing access;Time;Tissue Sample;Tissues;Tongue;tool;Tumor Burden;Tumor Tissue;ultrasound;Universities;Validation;Washington

PROJECT_TITLE: Validation of a saliva test using methylated microRNAs for head and neck cancer recurrence


NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Palliative Care;Patient Safety;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_CITY: NEW ROCHELLE

ORG_NAME: QUA, INC.

PHR: PPAL® PHASE II PROJECT NARRATIVE Toileting injuries have detrimental effects on older adults and individuals with mobility disability; new, easy-to- use technologies that enable more efficient and safer toilet transfers are desperately needed. This Phase II project continues the development and testing of a novel bedside commode (the “PPAL®”) that enables care recipients to transfer themselves onto a commode to toilet, rather than wait for caregiver lift assistance. The PPAL® uniquely engages the transfer skill of care recipients to manage their own transfer onto a commode. In so doing, it advances the clinical science of fall prevention and (by reducing the manual labor required for toileting assistance), safe patient handling and mobility.

PI_NAMEs: GRAHAM, MARGARET ELLEN (contact)

PROGRAM_OFFICER_NAME: WOLFF, JOSHUA R

PROJECT_TERMS: Adult;Adverse event;Age;aged;Aging;Algorithms;Area;arm;Articular Range of Motion;base;Beds;care recipients;Caregiver Burden;Caregivers;Caring;Clinical;clinical decision support;Clinical Sciences;Community Participation;cost;Data;design;Development;Devices;Diameter;Engineering;Equipment;Evaluation;fall injury;Fall prevention;fall risk;falls;fear of falling;Feedback;Formal caregiver;Goals;Guidelines;Health;Height;Home;Hospitals;improved;Incidence;Individual;Individuals with physical disabilities;informal caregiver;Injury;innovation;Institution;Interview;iterative design;Legal patent;Lifting;Location;Manuals;manufacturability;Mechanics;Methods;Mobility disability;Motor;Movement;novel;nursing skill;older adult;Older Population;operation;Outcome;Patient Transfer;Patients;Persons;Phase;phase 1 study;phase 2 study;Populations at Risk;Positioning Attribute;Posture;preservation;Production;prototype;Published Comment;Quality of life;Rehabilitation therapy;residence;Resort;Risk;Risk Reduction;safe patient;Self Efficacy;skills;Small Business Innovation Research Grant;Surface;System;Technology;Testing;tool;United States National Institutes of Health;usability;Weight;Wheelchair user;Wheelchairs;Work;Workers' Compensation

PROJECT_TITLE: Development and Evaluation of the PPAL Bedside Commode for Safe Independent Toileting Transfers


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: POTSDAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CLARKSON UNIVERSITY

PHR: A major challenge for the organized development and homeostasis of tissues and organs is the correct  spatial and temporal distribution of signaling molecules. Achieving a correct tissue organization is critical as  defects in patterning can lead to human disorders and disease. This project will take both multi-scale  mathematical modeling and experimental approaches to investigate how the signaling receptor Notch is  distributed and activated by active cell processes during lateral inhibition-mediated tissue patterning events.

PI_NAMEs: ASANTE-ASAMANI, EMMANUEL  (contact)

PROJECT_TERMS: Active Biological Transport;Address;Biological;Cell Physiology;Cells;Chest;Defect;Development;Diffusion;Disease;Distant;Event;experimental study;Filopodia;fly;genetic approach;Homeostasis;Human;Image;in silico;in vivo;Investigation;Lateral;mathematical model;Mechanics;Mediating;Modeling;Molecular;morphogens;multi-scale modeling;Multiscale Mechanics;National Institute of General Medical Sciences;notch protein;Organ;Pattern;Process;Receptor Signaling;Signal Transduction;Signaling Molecule;spatiotemporal;success;Testing;Time;Tissues;Work

PROJECT_TITLE: DMS/NIGMS 1: Multiscale modeling of Notch signaling during long-range lateral inhibition


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Telehealth

ORG_NAME: RIP ROAD, INC.

PHR: Project Narrative  The field is moving toward finding more sensitive clinical measures for early diagnosis and tracking of subtle changes over time that are associated with AD biomarkers but are easy and inexpensive to administer by primary care physicians, who are on the frontlines of the medical battle. Developing more sensitive, ecologically valid performance-based IADL tests like ASSET is vital to the goal of improving the tracking of individuals through the tipping point between preclinical AD and prodromal AD. ASSET has been designed to tap the high-level healthcare-related tasks that challenge seniors in daily life and are important to them, to serve as a clinically meaningful outcome measure for preclinical and prodromal AD trials, and to be easy and quick to administer remotely/at-home, using real-life devices.

PI_NAMEs: ERIC LEVEN, ERIC LEVEN ERIC LEVEN (contact);MARSHALL, GAD ASHER

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;amnestic mild cognitive impairment;Amyloid;Amyloid beta-Protein;Appointment;Award;Biological Markers;Boston;Businesses;Calendar;Caregiver Burden;Cellular Phone;Cerebrospinal Fluid;Clinic;Clinical;Clinical Trials;Cognitive;cognitive change;cognitive performance;cognitive testing;Collaborations;Communication;Computers;daily functioning;Data;Data Set;Dementia;design;Development;Devices;digital;Early Diagnosis;Emergency department visit;experience;functional decline;Future;Goals;health assessment;Health Personnel;Healthcare;Home;Hospitals;Impaired cognition;Impairment;improved;Individual;instrument;instrumental activity of daily living;Life;Measures;Medical;mild cognitive impairment;Monitor;Multicenter Studies;Neuropsychological Tests;novel;older adult;Older Population;Outcome Measure;Participant;patient portal;Patients;payment;Performance;performance site;Phase;Physical therapy;Physicians;Positron-Emission Tomography;pre-clinical;Prevention trial;Primary Care Physician;prodromal Alzheimer's disease;Questionnaires;recruit;remote administration;remote assessment;Research;response;Schedule;Secondary Prevention;Site;smartphone application;Source;Symptoms;System;Technology;Technology Transfer;Telephone;telephone based;Testing;Time;United States Food and Drug Administration;Visit;Voice;Woman;young adult

PROJECT_TITLE: The Assessment of Smart Phone Everyday Tasks (ASSET): A new IADL test for early AD


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Project Narrative: Dysfunction in the autonomic nervous system is poorly understood after spinal cord injury, leading clinicians to watch and wait for potentially devastating secondary complications to occur. The goal of this project is to characterize dysfunction in the cardiovascular component of the autonomic nervous system using a combination of lab, ambulatory, and imaging-based techniques. These results could give new insights into who will develop secondary complications and, by developing precision markers, lay the groundwork for accurately assessing future interventions to treat and prevent them.

PI_NAMEs: SOLINSKY, RYAN  (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Affect;Ambulatory Monitoring;Animal Model;Autonomic Dysfunction;Autonomic Dysreflexia;Autonomic nervous system;Autopsy;Blood Pressure;Boston;Cardiovascular system;career;career development;Caring;Catecholamines;Clinical;clinical application;Clinical assessments;Clinical Research;clinical translation;clinically actionable;Collaborations;Complication;computational neuroscience;cost;design;Doctor of Philosophy;dorsal horn;Educational process of instructing;Exercise;experimental study;foot;Functional disorder;functional improvement;Functional Magnetic Resonance Imaging;Funding;Future;Galvanic Skin Response;Goals;Grant;Health Care Costs;Healthcare;heart rate variability;Home;Hospitals;Human;Image;improved;improved outcome;Incidence;Individual;infancy;Injury;insight;Intervention;Knowledge;Laboratories;Link;Maps;Massachusetts;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;mortality;Motor;Nervous System Disorder;Neuroanatomy;neuroimaging;Neurologic;Neurologist;Neurons;neuroregulation;Neurosciences;novel;Paralysed;Pathway interactions;Pattern;Persons;Phenotype;Physical Medicine;Physical Rehabilitation;Physicians;Physiological;Physiology;Population;Population Heterogeneity;preservation;prevent;Proxy;Quality of life;Questionnaires;Recovery of Function;Regulation;Rehabilitation therapy;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;response;Rest;Role;Scientist;Secondary to;Sensory;Severities;Signal Transduction;skills;Skin Temperature;smart watch;Spinal Cord;Spinal cord injury;spinal cord mapping;Statistical Methods;stressor;Structure;Sympathetic Nervous System;Symptoms;System;Techniques;Testing;tool;Training;Translating;Translations;Work

PROJECT_TITLE: Deciphering Preserved Autonomic Function after Spinal Cord Injury

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE

PHR: Methamphetamine, HIV integration and latency in the brain  This project addresses a critical gap in our understanding of relationships between chromatin organization and proviral integration associated with latency in brain microglia cellular reservoirs of HIV, and particularly in the best experimental model, the SIV-rhesus macaque. While HIV integration and latency in tissues such as the brain are challenges to the cure, the relationships between HIV integration and chromatin dynamics may be drastically different in prevalent populations of HIV+ drug users, especially Methamphetamine. Following a two phase project, where a progression of models will lead to conclusions about HIV/SIV integration site frequency, location and markers, we expect to prove our hypothesis that Meth impacts chromatin structure in microglia, enhancing viral integration susceptibilities and that these effects vary between brain regions that differ in levels of dopaminergic projections, and their involvement in the addiction circuitry, leading to a paradigm shift about the role of brain regions and their heterogeneous microglia populations in the establishment of a reservoir state.

PI_NAMEs: MARCONDES, MARIA CECILIA GARIBALDI (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: addiction;Address;Affect;Animals;antiretroviral therapy;Architecture;Area;Basal Ganglia;Binding;Brain;Brain region;CCCTC-binding factor;Cell Line;Cell model;Cells;Central Nervous System;Central Nervous System Stimulants;Cerebellum;Characteristics;Chromatin;Chromatin Structure;Chronic;comparison control;Complex;Data;density;Dopamine;Dopamine Receptor;Drug usage;Drug user;Epigenetic Process;epigenomics;Exhibits;Experimental Models;Frequencies;Gene Expression Profile;Genes;Genetic Transcription;Genome;Genomic Segment;Genomics;Goals;Grant;Heterogeneity;HIV;HIV Infections;HIV-1;HIV-1 integrase;Human;In Vitro;in vitro testing;in vivo;in vivo Model;induced pluripotent stem cell;Infection;Inflammation;Inflammatory;insight;Intake;integration site;Link;Location;Macaca mulatta;Mediating;Methamphetamine;methamphetamine effect;methamphetamine use;Microglia;Modeling;neuroAIDS;Neurologic;Neurotransmitters;nonhuman primate;novel;Nucleus Accumbens;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;Phase;Population;Population Heterogeneity;Predisposition;Prefrontal Cortex;Provirus Integration;Publishing;response;Role;Site;SIV;Stimulant;Structure;substance use;Substantia nigra structure;System;Testing;Tissues;transcriptional coactivator p75;Validation;Ventral Tegmental Area;Viral;Viral Genome;Viral reservoir;Virus Integration;Work


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Lung cancer is the most commonly diagnosed cancer and the first leading cause of death in both men and women in the United Sates. In this proposal, we intend to understand of how Pdcd4, a tumor suppressor, binds with Rictor, an important protein, in suppression of the lung cancer cells. This work will provide new strategies for lung cancer with Rictor elevation therapeutics and potentially develop new agents for treatment of this type of lung cancer.

PI_NAMEs: YANG, HSIN-SHENG  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: 6-Phosphofructo-2-kinase;Acetylation;Apoptosis;Binding;Biological;Biological Assay;cancer cell;cancer diagnosis;Cancer Etiology;Cancer Patient;cancer type;Cause of Death;Cell Proliferation;Cell Survival;Cells;Cessation of life;Companions;Complex;Cultured Cells;Data;Death Rate;Drug Kinetics;Early Diagnosis;Event;Exhibits;Feedback;FRAP1 gene;Fructose;Gene Amplification;Genes;Genetic;Genetic Transcription;Glycolysis;Growth;improved;In Vitro;in vivo;Inhibition of Cell Proliferation;inhibitor;Invaded;Investigation;knock-down;Knock-out;Laboratories;lung cancer cell;lung tumorigenesis;Malignant neoplasm of lung;Maps;Mediating;men;Metabolic Pathway;metabolomics;migration;multicatalytic endopeptidase complex;mutant;Mutation;Mutation Analysis;Neoplasm Metastasis;New Agents;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;novel therapeutics;Nude Mice;Outcome Study;patient derived xenograft model;Patients;Penetration;Peptides;Phosphorylation;Phosphorylation Site;Phosphotransferases;precision medicine;prevent;Process;Prognosis;Proliferating;Proteasome Inhibitor;Proteins;Regulation;Reporting;research clinical testing;Resistance;response;Role;Signal Transduction;Sirolimus;Site;small cell lung carcinoma;Subgroup;Survival Rate;Tertiary Protein Structure;Testing;Therapeutic;therapy resistant;tumor;tumor growth;Tumor Suppressor Proteins;tumorigenesis;ubiquitin-protein ligase;Ubiquitination;United States;Up-Regulation;Woman;Work;Xenograft procedure

PROJECT_TITLE: Pdcd4-Rictor Interaction in Suppression of Lung Tumorigenesis

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Maternal Health;Pediatric;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

ORG_STATE: MO

PI_NAMEs: VARBERG, KAELA MARGARET (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Abnormal placentation;Adult;adverse outcome;adverse pregnancy outcome;Affect;ASCL2 gene;ATAC-seq;BHLH Protein;Binding;bisulfite sequencing;Breeding;career;Cell Line;Cell Lineage;Cells;ChIP-seq;Chromatin;chromosome conformation capture;Data;Development;Development Plans;Disease;DNA Methylation;early detection biomarkers;Embryo;Ensure;Enterobacteria phage P1 Cre recombinase;Environment;Epigenetic Process;epigenomics;Family;fetal;Fetal Growth Retardation;Fetus;Foundations;gene regulatory network;Genes;Genomics;Goals;Grant;Health;Hi-C;Human;Impairment;in vivo;innovation;Invaded;Knock-out;Lead;lentiviral-mediated;Life;LoxP-flanked allele;Mentored Clinical Scientist Development Award (K08);Mentors;methylation pattern;Modeling;Modification;Molecular;Molecular Conformation;Morbidity - disease rate;mortality;Mothers;mutant;Nutrient;Phase;Physiological;Placenta;Placentation;postnatal;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy Complications;Pregnancy loss;Premature Birth;Protocols documentation;Publications;Rattus;Regulation;Regulatory Element;Research;Research Project Grants;Resistance;response;Series;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Spiral Artery of the Endometrium;stem cell differentiation;Testing;trophoblast;trophoblast stem cell;Uterus;Vascular blood supply;Vascular remodeling;Villous;whole genome;Work

PROJECT_TITLE: Regulation of Invasive Trophoblast Cell Lineage Development

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Opioid Misuse and Addiction;Opioids;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Helping people with opioid-use disorder stay on medication treatment is paramount to battling this country’s opioid crisis. This project will develop a stigma-informed recovery support intervention for people initiating buprenorphine treatment, using an embodied conversation agent delivered via smartphones. We will also conduct a clinical trial to assess this intervention’s effects on retention in treatment for opioid-use disorder over one year, so that we can adequately design a subsequent effectiveness and implementation study.

PI_NAMEs: BICKMORE, TIMOTHY W.;LUNZE, KARSTEN  (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Abstinence;addiction;Address;Adherence;animation;arm;Behavior;Buprenorphine;buprenorphine treatment;Capital;Caring;Cellular Phone;chatbot;Clinic;Clinical Trials;Cognitive Therapy;common treatment;comparison intervention;Computers;Control Groups;coping;Country;dashboard;Data;depressive symptoms;design;Drops;Education;Effectiveness;effectiveness study;emotion dysregulation;Emotional;Emotions;Engineering;Enrollment;Exercise;experience;follow-up;Goals;group intervention;Health;Health Personnel;Healthcare;high risk;Hybrids;implementation study;improved;individual patient;instrument;Intervention;intervention effect;intervention participants;Intuition;long term recovery;low health literacy;low socioeconomic status;Measures;medication for opioid use disorder;mindfulness;motivational enhancement therapy;Opioid;opioid agonist therapy;opioid epidemic;opioid use;opioid use disorder;Outcome;outreach;Participant;Patients;Persons;Pharmaceutical Preparations;Pilot Projects;pilot test;pressure;primary outcome;Process;racial minority population;Randomized;Randomized, Controlled Trials;Recovery;recovery services;Recovery Support;recruit;relapse prevention;relapse risk;Resources;Sampling;smartphone application;Social isolation;social stigma;staff intervention;Stigmatization;Stress;Subgroup;substance use;sustained recovery;System;Testing;therapy design;Thinking;treatment as usual;treatment duration;treatment program;uptake;usability

PROJECT_TITLE: Sustaining recovery for people on opioid agonist treatment with conversational agents

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Digestive Diseases - (Gallbladder);Genetics;Immunotherapy;Liver Cancer;Liver Disease;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Isocitrate dehydrogenase is the most commonly mutated metabolic gene across all cancers, with a particular high frequency of mutation in cholangiocarcinoma, a deadly cancer of the liver bile ducts. Our prior studies using novel genetically engineered mouse models, patient-derived models, and patient samples showed that mutant IDH has central roles in driving immune-evasion and subverting cell differentiation. This proposal explores the underlying mechanisms and interplay of these process and determines how their reversal upon pharmacological inhibition of the mutant IDH1 contributes to biological and therapeutic response, thereby informing the improved treatment of cholangiocarcinoma and potentially the range of other cancer types harboring IDH mutations.

PI_NAMEs: EL-BARDEESY, NABEEL  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Address;Affect;Allografting;alpha ketoglutarate;Antigens;Automobile Driving;bile duct;Bile Duct Carcinoma;Biological;Biology;cancer type;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cells;Cholangiocarcinoma;CRISPR screen;CTLA4 blockade;Cytotoxic T-Lymphocytes;Data;demethylation;derepression;DNA;DNA Repair;Double-Stranded RNA;ds-DNA;Endogenous Retroviruses;Enzymes;Epigenetic Process;Epithelium;fascinate;FDA approved;Frequencies;Gene Expression;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Glioma;Growth;Hepatocyte;HNF4A gene;Human;IFNGR1 gene;Immune;immune checkpoint;immune checkpoint blockade;Immune Evasion;Immune signaling;Immune system;Immunologic Surveillance;Immunologics;immunoregulation;Immunosuppression;improved;in vivo;inhibitor;innate immune pathways;insight;Interferon Type II;Interferons;Intrahepatic Cholangiocarcinoma;IRF3 gene;Isocitrate Dehydrogenase;Malignant neoplasm of liver;Malignant Neoplasms;MAP3K7 gene;Mediating;Mediator;Metabolic;Metabolism;Modeling;Molecular;mutant;Mutate;Mutation;Natural Immunity;neoplastic cell;novel;Oncogenes;Pathway interactions;Patients;pharmacologic;Phenotype;prevent;Process;Production;programs;Proteins;recruit;Recurrence;Recurrent tumor;Regulatory T-Lymphocyte;Resistance;response;restoration;Reverse Transcription;Role;Sampling;sensor;Signal Transduction;Solid Neoplasm;Stimulator of Interferon Genes;synergism;T cell infiltration;T-Cell Depletion;T-cell receptor repertoire;T-Lymphocyte;Testing;therapeutic development;transcription factor;transcriptomics;Treatment Failure;treatment response;tumor;tumor growth;Tumor Immunity;tumor progression;Tumor Promotion;Up-Regulation;Work

PROJECT_TITLE: Functions of mutant IDH in cholangiocarcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative The proposed research is relevant to public health because it accelerates the development and implementation of high-confidence predictive tools able to minimize the harm of unnecessary antibiotics on critically ill and injured children. Following appropriate evaluation of our machine learning-based predictive models and the design of model-based clinical decision support tools, we will be poised to effect significant improvement in pediatric antibiotic decision-making with reductions in antibiotic-associated harm including acute kidney injury, clostridium difficile colitis, and the development of antibiotic resistance. This project is well aligned with the missions of the NIH and NICHD given its potential to reduce illness and disability and enhance the lives of children and adolescents.

PI_NAMEs: MARTIN, BLAKE  (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Acceleration;Acute Renal Failure with Renal Papillary Necrosis;Admission activity;Adolescent;Adverse effects;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Automobile Driving;Award;Bacterial Infections;Biological;Biometry;Calibration;career development;Child;Childhood;Childhood Injury;Clinical;Clinical Data;clinical decision support;Clinical Decision Support Systems;cohort;computer human interaction;Critical Illness;Critically ill children;Data;Data Set;Decision Making;design;Development;disability;Education;Electronic Health Record;Equity;Ethics;Evaluation;Exclusion;experience;Functional disorder;Funding;Goals;Harm Reduction;High Prevalence;Hospitals;Hour;improved;improved outcome;Infection;innovation;Institution;Interview;Knowledge;Laboratories;Left;Length of Stay;Life;Machine Learning;machine learning method;machine learning model;machine learning prediction;Mentors;Methods;Mission;model design;model generalizability;Modeling;mortality;Multicenter Trials;multidisciplinary;National Institute of Child Health and Human Development;novel;Organ;Outcome;Patient-Focused Outcomes;Patients;Pattern;Pediatric Hospitals;Pediatric Intensive Care Units;pediatric sepsis;Performance;predictive modeling;predictive tools;Predictive Value;Probability;prospective;Provider;Pseudomembranous Colitis;Public Health;Qualifying;Research;Research Design;Research Personnel;Retrospective cohort;Risk;Sepsis;severe injury;Site;skills;support tools;System;Technical Expertise;Testing;Time;tool;tool development;Transcript;treatment duration;Trust;United States National Institutes of Health;user centered design;Work

PROJECT_TITLE: Predicting the Absence of Serious Bacterial Infection in the PICU

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Chronic Pain;Complementary and Integrative Health;Neurodegenerative;Neurosciences;Opioids;Pain Research;Peripheral Neuropathy

ORG_CITY: MARS

ORG_NAME: VANISH THERAPEUTICS INC.

PHR: Project Narrative We aim to develop a bioresorbable, non-surgical and minimally invasive peripheral nerve stimulator to treat chronic pain. Once injected, the device will provide pain relief through electrical stimulation and then be safely degraded and resorbed by the body afterwards. This provides a new pain management option without the risk of opioids or high complications from the permanent and surgically implanted stimulators.

PI_NAMEs: CUI, XINYAN TRACY (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Acceleration;Address;alternative treatment;Ambulatory Care Facilities;Animals;Back;Biological Assay;bioresorption;Certification;Cessation of life;Chronic;chronic pain;chronic pain management;Cicatrix;Clinical;clinical pain;clinical translation;Code;Complex Regional Pain Syndromes;Complication;cost;Coupled;Custom;cytotoxicity;Data;design;Development;Devices;Diagnosis;digital;Direct Costs;electric impedance;Electric Stimulation;Electrodes;Electrophysiology (science);Excision;Facilities and Administrative Costs;FDA approved;Foundations;Fracture;genotoxicity;Goals;Health;Health Personnel;Healthcare Systems;Histology;Implant;In Vitro;Inflammation;Inflammatory;Injectable;integrated circuit;irritation;Lead;lead optimization;Local anesthesia;Lymphoma;Magnetic Resonance Imaging;Measurement;Metals;miniaturize;minimally invasive;Modeling;Monitor;Mus;Needles;Nerve;Nervous System;non-opioid analgesic;operation;Operative Surgical Procedures;Opioid;opioid epidemic;opioid sparing;Pain;Pain management;pain model;pain perception;pain relief;painful neuropathy;Patients;Periodicity;Peripheral Nerves;Phase;Physiologic pulse;Physiological;Polyurethanes;preclinical safety;Property;Rattus;Reaction;response;Risk;Safety;Saline;Second Look Surgery;Signal Transduction;Site;Skin;Small Business Technology Transfer Research;Spectrum Analysis;Speed;Spinal Cord;Stimulus;Surgical incisions;System;technology research and development;Testing;Therapeutic;Tissues;Toxic effect;ultrasound;United States;voltage;wearable device

PROJECT_TITLE: Opioid-Sparing Non-Surgical, Bioresorbable Nerve Stimulator for Pain Relief

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-C(10)B]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The wider application of allogeneic hematopoietic cell transplantation (HCT), a potentially curative therapy against many blood diseases has been limited by its most significant complication, graft-versus- host disease (GVHD). Our proposal aims to understand the role of diet on the host (patient) and their microbial metabolism in mitigating GVHD. If successful, could pave way for improving the outcomes of allogeneic HCT through rational dietary and microbial modifications.

PI_NAMEs: REDDY, PAVAN ;TEWARI, MUNEESH  (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Acceleration;Address;Allogeneic Bone Marrow Transplantation;Allogenic;Applications Grants;bench-to-bedside translation;Big Data;Bile Acids;Bioinformatics;Biological Models;Biology;Biometry;Bone Marrow Transplantation;Butyrates;Cells;Clinical;Clinical Trials;Communication;Complex;Complication;cost efficient;curative treatments;Data Set;Diet;dietary;Documentation;Engineering;Epithelial Cells;Feedback;Fostering;Genomics;Germination;Gnotobiotic;Goals;graft vs host disease;Hematological Disease;Hematopoietic;Hematopoietic Stem Cell Transplantation;hematopoietic transplantation;high throughput technology;High-Throughput Nucleotide Sequencing;Homeostasis;host microbiome;Human;Immunology;improved;improved outcome;Individual;insight;Institution;Institutional Review Boards;intestinal epithelium;Intestinal Graft Versus Host Disease;intestinal homeostasis;Intestines;Investigation;Joints;Malignant - descriptor;Martens;meetings;member;Metabolism;Metabolite Interaction;metabolome;metabolomics;Michigan;Microbe;microbial;microbial community;Microbial Genome Sequencing;microbiome;Mitochondria;Modification;Molecular;Monitor;mouse model;Mus;Non-Malignant;novel;operation;Patients;Phenotype;Pre-Clinical Model;Production;Productivity;Program Research Project Grants;programs;prospective;Publications;Publishing;Research;Research Personnel;Resistance;Role;Severities;Shapes;Starch;synergism;Testing;Time;Translations;Transplant Recipients;Transplantation;Universities;Validation;Volatile Fatty Acids;Work

PROJECT_TITLE: Host and Microbial Metabolism in Graft versus Host Disease

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(OA)]


NIH_SPENDING_CATS: Microbiome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: REDDY, PAVAN  (contact)

PROJECT_TERMS: Accountability;Allogenic;Applications Grants;Bioinformatics;Biological;Biological Markers;Biological Models;Biometry;Biostatistics Core;Clinical;Clinical Trials;Clinical Trials Design;Communication;Data;data integration;data sharing;Diet;disease model;Documentation;Exclusion;Experimental Animal Model;Experimental Designs;graft vs host disease;Hematopoietic Stem Cell Transplantation;Human;Intestines;large datasets;Link;Metabolism;metabolome;metabolomics;microbial;microbiome;model building;Monitor;Program Research Project Grants;Regulation;Reporting;Sample Size;Services;Standardization;Statistical Data Interpretation;synergism;transcriptome sequencing;Transplant Recipients;United States National Institutes of Health;Validation

PROJECT_TITLE: Administrative and Biostatistics Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


NIH_SPENDING_CATS: Digestive Diseases;Hematology;Microbiome;Nutrition;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PI_NAMEs: LYSSIOTIS, COSTAS ANDREAS (contact)

PROJECT_TERMS: Address;Allogenic;Amino Acids;assay development;bile acid metabolism;Bile Acids;Bioenergetics;Bioinformatics;Biological Assay;Biostatistics Core;Blood specimen;Butyrates;Carbohydrates;Carbon;Cells;chronic infection;Clinical Trials;Colon;Data;Data Analyses;Data Collection;Development;Disease;Ensure;Epithelial Cells;Epithelium;experience;Feces;gastrointestinal;Gastrointestinal tract structure;Genetic Diseases;Genus Hippocampus;Glucose;Gnotobiotic;graft vs host disease;Graph;gut microbiome;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Human;in vivo Model;Incidence;Informatics;insight;Label;Laboratories;large datasets;lipidome;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methodology;Methods;microbial;microbial community;microbiome;microbiome analysis;Morbidity - disease rate;Mus;Nature;Nitrogen;Nutrient;nutrient metabolism;Organism;participant enrollment;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Plasma;Population;prevent;Production;Program Research Project Grants;programs;Property;Research Project Grants;Research Proposals;Research Support;Resources;Safety;Severities;stable isotope;Starch;Statistical Data Interpretation;stool sample;Technology;Therapeutic;Tissues;Toxic effect;Tracer;uptake;Volatile Fatty Acids

PROJECT_TITLE: Metabolomics Core


PI_NAMEs: MARTENS, ERIC C (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Activities of Daily Living;Address;Automobile Driving;Bacterial Genome;Behavior;Bile Acids;bile salts;Biological Assay;Biological Models;Butyrates;Carbohydrates;Communities;Complex;Consumption;Coupled;Custom;Development;Diet;dietary;Disease;disease model;Disease Progression;Ecosystem;Enterococcus;Enterococcus faecalis;experience;experimental study;fecal transplantation;Fiber;Gastrointestinal tract structure;Generations;Genes;Genetic;Genome;genome sequencing;Germ-Free;Gnotobiotic;Goals;graft vs host disease;Growth;gut bacteria;gut microbes;gut microbiome;host microbiome;Human;Hydrolase;Hydrolysis;Implant;In Vitro;Individual;individual patient;Infection;insight;Intervention;Knowledge;lens;Martens;Measurement;Measures;member;Metabolic;metabolic phenotype;Metabolism;metagenome;Metagenomics;Microbe;microbial;microbial community;microbial composition;microbiome research;microbiota;microorganism;microorganism culture;microorganism interaction;Modeling;Modification;Mucous Membrane;Mus;Nutrient;Organism;Outcome;Patients;Phenotype;Polysaccharides;Positioning Attribute;Potato;preservation;Production;reconstitution;Refractory;Renaissance;Resistance;Resources;response;Role;Sampling;Starch;symbiont;Symbiosis;synthetic construct;System;Technology;Testing;Time;Transplantation;Variant;Work

PROJECT_TITLE: Gnotobiotics mice and bacterial cultures phenotyping core


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Working memory is our ability to maintain important information across short periods of time, while permitting us to manipulate this information to reason through problems and solve tasks. The neuromodulator dopamine is theorized to be critical in several aspects of working memory functioning but validating these theories has been impossible prior to the methodological advances that we use in this proposal. Using machine-learning- enhanced voltammetry to measure dopamine release in the lateral prefrontal cortex, anterior cingulate cortex, and hippocampus we will acquire high temporal resolution recordings to test key theories about dopamine’s role in selecting information to store in working memory and maintaining this information across time.

PI_NAMEs: MONTAGUE, P READ (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TITLE: Direct Dopamine Recording From Humans Engaging Working Memory

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Microbiome;Rare Diseases;Transplantation

PI_NAMEs: DICK, GREGORY JAMES (contact)

PROJECT_TERMS: Address;Allogenic;analysis pipeline;Bile Acids;Bioinformatics;bioinformatics pipeline;bioinformatics tool;Butyrates;Cells;Cellular Metabolic Process;Clinical Research;Clinical Trials;Communication;Complex;congenital immunodeficiency;Data;Data Analyses;Data Set;data streams;Databases;Development;Diet;Dietary Intervention;Dimensions;disorder prevention;diverse data;DNA;DNA Sequence;DNA sequencing;Emerging Technologies;Ensure;experimental study;flexibility;Fostering;gastrointestinal;genome sequencing;Genomics;Goals;graft vs host disease;Health;Hematological Disease;Hematopoietic Stem Cell Transplantation;heterogenous data;Human;Immune response;Individual;intestinal epithelium;Laboratories;Life;Link;Maintenance;Metabolism;metabolome;metabolomics;Metadata;Methods;microbial;microbiome;microbiome composition;MicroRNAs;Mitochondrial DNA;Modeling;mouse model;Mus;Nature;Nuclear;Oral Administration;Outcome;Patients;Plasma;Postdoctoral Fellow;Potato;Research;Research Personnel;Research Project Grants;Research Support;Resistance;RNA;rRNA Genes;Science;Scientist;Severities;Shapes;Shotguns;Source;Starch;Statistical Data Interpretation;student training;Students;tool;Training;transcriptome sequencing;transcriptomics;user-friendly;Volatile Fatty Acids;Work

PROJECT_TITLE: Bioinformatics Core


NIH_SPENDING_CATS: Digestive Diseases;Microbiome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PROJECT_TERMS: Affect;Allogeneic Bone Marrow Transplantation;Allogenic;Apoptosis;assault;Attenuated;Bacteria;Biological;Biology;Butyrates;Cells;Cellular Metabolic Process;Complex;Complication;Data;Defect;Diet;Disease Outcome;Electron Transport;Environment;Epithelial Cells;Epithelium;Exposure to;gastrointestinal;Generations;Glycolysis;graft vs host disease;gut microbiome;Hematological Disease;Hematopoietic Stem Cell Transplantation;host microbiome;Hypoxia;Immune;Immune System Diseases;Immunosuppression;Inflammation;insight;intestinal epithelium;Knowledge;Maintenance;Metabolic;Metabolic Pathway;Metabolism;microbial;microbiome;Mitochondria;mitochondrial metabolism;novel;Oxygen;Play;Regulation;Research Personnel;resilience;response;Role;Secondary to;Seminal;Severities;Severity of illness;side effect;Stress;Stress and Coping;stress state;Succinate Dehydrogenase;T-Lymphocyte;Testing;therapeutic target;Tissues;Volatile Fatty Acids

PROJECT_TITLE: Crosstalk between host (IEC) mitochondria and microbial metabolism in GVHD


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Hematology;Immunotherapy;Infectious Diseases;Liver Disease;Microbiome;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PI_NAMEs: NUNEZ, GABRIEL  (contact)

PROJECT_TERMS: Acute Graft Versus Host Disease;Address;Affect;Allogenic;Amino Acids;Anaerobic Bacteria;Antibiotics;Bacteria;Bile Acid Biosynthesis Pathway;bile acid metabolism;Bile Acids;bile salts;Blood Circulation;Cholesterol;Cholic Acids;Clinical;Death Rate;dehydroxylation;Deoxycholic Acid;Development;Dietary Fats;Duodenum;Enterococcus;Enterococcus faecalis;Enzymes;fecal transplantation;Food;Gallbladder;Generations;genetic approach;Genetic study;Glycine;Gnotobiotic;GPBAR1 gene;graft vs host disease;Growth;gut colonization;Hematopoietic Stem Cell Transplantation;hematopoietic transplantation;Hospitals;Human;Hydrolase;in vivo;Infection;Ingestion;Integration Host Factors;Intestinal Absorption;intestinal homeostasis;Intestines;Liver;Mediating;member;Metabolism;microbial;microbiota;Modeling;Modification;mouse model;Mus;Patients;Physiological Processes;Plasmids;Production;receptor;Regulation;response;Role;Sepsis;Signal Induction;Taurine;transmission process;United States;Vancomycin;Vancomycin Resistance;Vancomycin resistant enterococcus

PROJECT_TITLE: Bile acids in intestinal homeostasis and allogeneic hematopoietic transplantation


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dietary Supplements;Digestive Diseases;Microbiome;Nutrition;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: SCHMIDT, THOMAS M (contact)

PROJECT_TERMS: Age;Agonist;Anabolism;Anaerobic Bacteria;Attenuated;Bacteria;Bifidobacterium;Bile Acids;bile salts;Binding;Biogenesis;Bioinformatics;Biological Models;Butyrates;Carbohydrates;Carbon;Cell Fraction;Cell Nucleus;Cell Respiration;Cells;Clinical;cohort;Colon;Communities;Consumption;cytochrome c oxidase;dietary supplements;Energy-Generating Resources;Engineering;Environment;Enzymes;Epithelial Cells;Excision;Exposure to;Fermentation;Fiber;Food Webs;gastrointestinal epithelium;Gene Expression;Germ-Free;Gnotobiotic;Goals;graft vs host disease;gut bacteria;gut inflammation;gut microbes;gut microbiome;gut microbiota;Gut Mucosa;Harvest;Hematopoietic Stem Cell Transplantation;high throughput screening;Human;Hydrogen;Hydrolase;Hydrolysis;In Vitro;in vivo;Incidence;Inflammation;Internet;intestinal epithelium;Measures;Mediating;Mesalamine;Metabolic;Metabolism;Microbe;microbial;microbial community;microbiome;microbiome analysis;Mitochondria;Modeling;Molecular;Molecular Probes;mouse model;Mucous Membrane;Mus;oxidation;Oxygen;particle;Patient-Focused Outcomes;Patients;Peroxisome Proliferator-Activated Receptors;Physiological;Potato;preservation;Production;Proteins;Proteomics;Receptor Activation;Resistance;Respiration;response;Ruminococcus;Scaffolding Protein;Severities;Starch;Succinate Dehydrogenase;Taxonomy;Testing;Therapeutic;Time;Tissues;Transplant Recipients;Volatile Fatty Acids;western diet

PROJECT_TITLE: Engineering microbiomes and their molecular determinants for production of butyrate and secondary bile acids from resistant starch