NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

PROJECT_TERMS: Address;Affect;Age;Algorithms;analytical tool;Anatomy;Archives;Basic Science;Behavior assessment;Bioinformatics;Brain;Brain imaging;BRAIN initiative;Clinical;Clinical Research;Cognition;cohort;Collaborations;Collection;Common Data Element;Communities;Computer software;Data;data archive;Data Collection;Data Element;data harmonization;data management;data modeling;Data Provenance;Data Set;Data Sources;data standards;Descriptor;design;Development;digital;Disease;Ecosystem;Effectiveness;Electronics;Engineering;Ensure;Environment;experience;experimental study;FAIR principles;Funding;Generations;Genetic;Goals;Health;Human;Image;improved;Informatics;information model;innovation;insight;Internet;Investments;Knowledge;knowledge integration;Learning;Libraries;Life Cycle Stages;light weight;Literature;Metadata;Mission;mobile sensor;Modeling;Multilingualism;neuroimaging;Ontology;Operating System;Output;Participant;peer;Population;Process;Proliferating;Protocols documentation;Publications;Recommendation;Reporting;Reproducibility;Research;Research Personnel;research study;Resources;Running;Scanning;Science;Semantics;Services;software development;sound;Standardization;statistics;stem;Structure;synergism;Technology;technology research and development;Terminology;Testing;Time;tool;Training;Training Activity;Trust;Visualization;Vocabulary;Work

PROJECT_TITLE: Improving Research Efficiency through Better Descriptors


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;HIV/AIDS;Human Fetal Tissue;Infectious Diseases;Nanotechnology

ORG_CITY: TUCSON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The patients infected with HIV require lifelong treatment with antiretroviral drugs. Tenofovir prodrugs, tenofovir disoproxil fumarate and tenofovir alafenamide fumarate, are an integral part of the first-line therapy for the management of HIV infections, but tenofovir prodrugs have low oral bioavailability. This project will develop novel strategies to improve oral bioavailability of tenofovir prodrugs which will eventually improve their antiviral activity and required therapeutic dose.

PI_NAMEs: DATE, ABHIJIT A (contact)

PROGRAM_OFFICER_NAME: PROTOPOPOVA, MARINA

PROJECT_TERMS: ABCB1 gene;Acids;amphiphilicity;Anions;Anthelmintics;Anti-Retroviral Agents;anti-viral efficacy;antiretroviral therapy;aqueous;benzimidazole;biodegradable polymer;Biodistribution;Biological Availability;BLT mice;Brain;Cations;chemical stability;Chronic Hepatitis B;Clinical;clinical development;Cost Savings;Cryptococcosis;Data;Developed Countries;Development;Diphosphates;Dose;Drug Kinetics;Drug Utilization;efficacy evaluation;efficacy testing;Electrostatics;Encapsulated;Enhancers;Evaluation;FDA approved;Formulation;Fumarates;Gastrointestinal tract structure;Goals;Hepatitis B Therapy;High Pressure Liquid Chromatography;HIV;HIV Infections;HIV-1;HIV/AIDS;Hydrolysis;hydrophilicity;Hydrophobicity;improved;improved outcome;in vivo;in vivo evaluation;Infection;inter-individual variation;Liquid substance;low and middle-income countries;lymph nodes;Mediating;melting;Metabolic;Metformin;Methods;Modeling;mouse model;Mus;nanomicelles;nanopolymer;Nature;novel;novel strategies;Oleic Acids;Oral;Oral Administration;Patients;Permeability;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Play;Polymers;pre-exposure prophylaxis;Predisposition;premature;Prodrugs;Research;Role;Salts;Sodium;Solubility;Temperature;Tenofovir;Testing;Therapeutic;Time;Tissues;Treatment Cost;Vagina;Vertebral column;Viral Physiology

PROJECT_TITLE: Ionic Liquids of tenofovir prodrugs for improved oral bioavailability and antiviral efficacy

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

ORG_STATE: CA

PHR: The proposed research is relevant to public health as it focuses on extrachromosomal DNA (ecDNA), which is frequently observed in particularly aggressive cancers. These studies will improve our understanding of the molecular mechanisms that drive tumor heterogeneity and treatment resistance in some of the most difficult-to- treat medulloblastoma patients. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to the causes, prevention, and cure of human diseases.

PI_NAMEs: CHAVEZ, LUKAS  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Biological;Biopsy;Bromodomains and extra-terminal domain inhibitor;cancer genomics;Cancer Patient;Cells;Chemotherapy and/or radiation;Child;Childhood Malignant Brain Tumor;Circular DNA;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;combinatorial;Combined Modality Therapy;Computing Methodologies;Data;data repository;Dependence;detection method;Development;developmental disease;Disease;Disease Progression;DNA;DNA Repair;DNA-PKcs;Enhancers;experimental study;extrachromosomal DNA;Functional dependence;Gene Amplification;Genes;Genetic Transcription;genome sequencing;high risk;Human;human disease;Image;improved;In Vitro;in vivo;Individual;inhibitor;innovation;Institution;Investigation;Malignant Neoplasms;Mediating;Medulloblastoma;Methods;Mission;Molecular;Molecular Analysis;Molecular Evolution;Monitor;multiple omics;MYCN gene;Neoplasm Metastasis;neoplastic cell;Nervous System Trauma;Nonhomologous DNA End Joining;novel;novel therapeutic intervention;Oncogenes;Oncoproteins;Outcome;Pathogenesis;patient derived xenograft model;Patients;Pediatric Hospitals;Poly(ADP-ribose) Polymerase Inhibitor;preclinical study;Predisposition;Prevention;Primary Neoplasm;Process;Proliferating;Property;Public Health;reconstruction;Relapse;Research;Resistance;Role;Sampling;single nucleus RNA-sequencing;standard care;standard of care;Subgroup;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Treatment Efficacy;Treatment Failure;tumor;Tumor Biology;tumor growth;tumor heterogeneity;Tumorigenicity;United States National Institutes of Health;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Investigation of ecDNA as a driver of intratumoral heterogeneity and treatment resistance in high-risk medulloblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-C(02)M]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Machine Learning and Artificial Intelligence;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE This project will develop novel real-time 3D MRI technology, using continuous radial sampling, motion-resolved reconstruction, and deep learning, for MRI-guided adaptive radiotherapy of unresectable pancreatic cancer. Our new approach for real-time 3D MRI, named MR signature matching (MRSIGMA), pre-learns 3D motion states and corresponding signatures during an offline learning phase and then performs fast signature acquisition and matching to one of the pre-learned 3D motion states to minimize latency and offer a real-time solution. The novel real-time MRI technology will unlock the potential of the MR-Linac for pancreatic cancer and enable the use of curative doses rather than palliative doses, with minimal risk in patients who currently do not have a chance for long-term survival.

PI_NAMEs: OTAZO, RICARDO  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;Affect;Anatomy;Area;Breathing;Cancer Etiology;Cessation of life;Collaborations;Collimator;convolutional neural network;curative treatments;Data;Databases;Death Rate;deep learning;Diagnostic Imaging;Dimensions;Dose;Electromagnetics;Excision;gastrointestinal;Gastrointestinal tract structure;Generations;Goals;heart motion;Image;imaging modality;Implant;Inferior;Learning;Linear Accelerator Radiotherapy Systems;Link;Liver neoplasms;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Malignant Neoplasms;Methods;minimal risk;Motion;Names;novel;novel strategies;Oncology Group;Operative Surgical Procedures;Organ;Output;palliative;pancreas radiation therapy;Patients;Performance;Phase;Plant Leaves;Positioning Attribute;prognostic;Radial;Radiation;Radiation Dose Unit;Radiation Oncology;Radiation therapy;real-time images;reconstruction;Reproducibility;Respiration;respiratory;Sampling;Scanning;Shapes;soft tissue;software development;standard care;Survival Rate;System;Techniques;Technology;Three-Dimensional Imaging;Time;Toxic effect;treatment planning;tumor;Unresectable;Validation;volunteer;X-Ray Medical Imaging

PROJECT_TITLE: Real-time MRI-guided adaptive radiotherapy of unresectable pancreatic cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative A large investment in time and money is made to support neuroimaging research to understand how brain structure and function develops and ages, and how various disorders affect it. However, much of this research, while very valuable, is performed on a relatively small number of subjects and is reported in a way that makes it difficult to replicate or assess its generalization across the population. ReproNim: A Center for Reproducible Neuroimaging Computation, provides a re-executable framework for capturing data and performing neuroimaging analysis. In this renewal, we seek to improve the efficiency of this framework in support of improving all clinical and research studies using neuroimaging.

PI_NAMEs: KENNEDY, DAVID NELSON (contact)

PROJECT_TERMS: Accounting;Adopted;Affect;Age;analysis pipeline;Archives;Back;base;Brain;Clinical Research;Cloud Computing;Collaborations;Collection;Communities;comparative;Complement;Complex;computational platform;computer infrastructure;Computer software;computing resources;Data;Data Analyses;Data Collection;data curation;Data Discovery;data management;Data Provenance;Data Reporting;data resource;data sharing;Data Sources;data standards;Descriptor;design;Development;digital;Disease;Ensure;Environment;Event;experience;Experimental Designs;experimental study;Feedback;flexibility;graphical user interface;Harvest;Heterogeneity;High Performance Computing;Image;improved;Infrastructure;Internet;Intervention;Investigation;Investments;Knowledge;Maintenance;Manuals;Measures;Metadata;Monitor;neuroimaging;new technology;novel strategies;operation;phenotypic data;Physiological;Population;Process;quality assurance;Reporting;Reproducibility;Research;Research Personnel;research study;Resources;Running;Science;Scientist;Services;side effect;software development;Software Tools;Standardization;Stimulus;Structure;synergism;Technology;technology research and development;Testing;Time;tool;Training Activity;Training Support;Work

PROJECT_TITLE: Efficient and reproducible execution from data collection to processing


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Influenza;Lung;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pneumonia;Pneumonia and Influenza;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: CINCINNATI

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative Early-life antibiotic exposure leads to lasting immune dysregulation that plays a role in high neonatal susceptibility to viral pneumonia, although the role for this antibiotic exposure on tissue- resident CD8+ T cell function is unclear. This proposal aims to define how early-life antibiotic exposure affects the formation and function of tissue-resident CD8+ cells following primary and heterotypic challenge with Influenza A. Fully characterizing the many complex factors that come together to control the cellular behavior of these tissue-resident CD8+ T cells will allow us to design the best vaccines and therapeutic immune support for these at-risk neonates.

PI_NAMEs: STEVENS, JOSEPH JACOB (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Adoptive Transfer;Adult;Affect;age group;Antibiotic Therapy;Antibiotics;Automobile Driving;Behavior Control;Biological Assay;career;CD8-Positive T-Lymphocytes;CD8B1 gene;cell behavior;Cell Physiology;Cells;Cellular Assay;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Childhood;Chromatin;Clinic;commensal microbes;Complex;cross immunity;cytokine;cytotoxicity;Data;design;Development;doctoral student;Early identification;Epigenetic Process;Exposure to;Flow Cytometry;Foundations;Frequencies;Future;Gene Expression;gene regulatory network;Genetic Transcription;Host Defense;Immune;Immunity;Immunotherapeutic agent;Impairment;Infection;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;influenzavirus;insight;interstitial;Knowledge;Laboratories;Life;Lower Respiratory Tract Infection;Lung;Measurement;Measures;Mediating;Memory;Morbidity - disease rate;mortality;Mus;Neonatal;Neonatal Intensive Care Units;neonatal mice;Neonatal Mortality;neonatal pneumonia;neonate;new therapeutic target;novel;Outcome;pathogen;Pediatric Hospitals;Physicians;Pneumonia;Population;postnatal;Predisposition;Premature Infant;Production;Proliferating;Publishing;Reporting;Risk;RNA;Role;Scientist;Signal Transduction;single cell ATAC-seq;Suspensions;T-Lymphocyte;Testing;Thymectomy;Tissues;Transcription Alteration;transcription factor;transcription regulatory network;Transposase;Vaccines;Viral Load result;Viral Pneumonia;Virus;Virus Diseases;Work

PROJECT_TITLE: CD8+ tissue-resident immunity to primary and heterotypic Influenza A controlled by commensal microbiota


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: Project Narrative The proposed studies aim to elucidate the pathogenesis, particularly that involving the innate and adaptive immune mechanisms, in glaucoma — a debilitating eye disease affecting 80 million people worldwide. Results from completing the proposed studies may reveal new directions in developing mechanism-based diagnostics, prevention and treatment.

PI_NAMEs: CHEN, DONG FENG  (contact);CHEN, JIANZHU ;SHEN, LUCY Q

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: adaptive immune response;adaptive immunity;Affect;Age;Antigens;Attenuated;Automobile Driving;Axon;axon injury;axonal degeneration;Biological Markers;Blindness;Brain;CD4 Positive T Lymphocytes;Cell Count;cell injury;cell type;Cells;Central Nervous System;Clinical;Collaborations;commensal microbes;Deterioration;Development;Diagnosis;Diagnostic;Disease;driving force;Ear;Event;Exhibits;extracellular;Eye;Eye diseases;Frequencies;Germ-Free;Glaucoma;glial activation;Heat shock proteins;HSPB1 gene;Human;Immune;Immune response;Immune Tolerance;immunogenic;Immunologic Markers;Individual;Inflammation;Inflammatory;Inflammatory Response;Inherited;Innate Immune Response;Interferon Type II;intravitreal injection;Link;Massachusetts;Mediating;Medical;Microglia;Modeling;Molecular;mouse model;Mus;Natural Immunity;Nerve Degeneration;neural;Neurodegenerative Disorders;neuroinflammation;Neurons;novel;Optic Nerve;Pathogenesis;Pathogenicity;Patients;peripheral blood;Persons;Phase;Physiologic Intraocular Pressure;Pilot Projects;Prevention;Primary Open Angle Glaucoma;Productivity;progressive neurodegeneration;protein expression;Recording of previous events;Regulatory T-Lymphocyte;Reporting;Research Personnel;Research Proposals;response;Retina;retinal damage;retinal ganglion cell degeneration;Retinal Ganglion Cells;Risk Factors;Signal Induction;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Specialist;Spinal Cord;Stress;T cell infiltration;T cell response;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Testing;Up-Regulation;Vision;Visual Fields

PROJECT_TITLE: Innate and Adaptive Immunity in the Pathogenesis of Glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Single-cell RNA sequencing (scRNA-seq) provides genome-wide information on gene expression at single-cell resolution, and is revolutionizing the progress of biomedical research. The size and complexity of this data necessitates the development of computational algorithms that can distill critical biological insights from high- dimensional datasets. Here, we propose to develop and test an innovative new class of algorithms that are aimed at reducing the potential for noise and bias in the analysis of scRNA-seq data.

PI_NAMEs: DEEDS, ERIC J (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Adipose tissue;Algorithms;analysis pipeline;B-Cell Development;B-Cell Lymphomas;Benchmarking;Binomial Model;Biological;Biological Preservation;Biomedical Research;Candidate Disease Gene;cell type;Cells;Collaborations;Communities;Complex;Computational algorithm;Computer software;computerized tools;Data;Data Analyses;data complexity;data imputation;Data Set;data visualization;deep neural network;Development;Diabetes Mellitus;dimension reduction;Dimensions;Disease;experimental study;feature selection;Gene Expression;Gene Expression Regulation;Genes;Genetic Markers;genome-wide;Geometry;Goals;Homeostasis;imaging Segmentation;improved;Individual;innovation;insight;Knowledge;Malignant Neoplasms;Measurement;Messenger RNA;Methods;Microscopy;Modeling;multidimensional data;Neighborhoods;Noise;novel;novel strategies;Pharmaceutical Preparations;Population;Process;Research Personnel;Resolution;single-cell RNA sequencing;Source;Statistical Models;Structure;Techniques;Testing;Three-Dimensional Image;Tissue-Specific Gene Expression;Tissues;tool;Training;Translating;treatment response;Variant;Visualization;Work

PROJECT_TITLE: Developing tools for the unbiased analysis and visualization of scRNA-seq data

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

ORG_CITY: FARMINGTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative: PP1 is a ubiquitous ser/thr protein phosphatase, which regulates >70% of all dephosphorylation reactions in higher eukaryotes. Despite decades of research, it has not been established how PP1 is activated in the cell. We have assembled a team of researchers that will be able to overcome this impediment and to allow for novel biological insights to be gained.

PI_NAMEs: PETI, WOLFGANG  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Area;ATP phosphohydrolase;Binding;Biochemical;Biogenesis;Biological;Biological Process;Biology;biophysical tools;Biophysics;cell growth;Cells;Cellular biology;Complex;Cysteine;Data;Development;dimer;Disease;Dissociation;Drug Targeting;Enzymes;Essential Genes;Eukaryota;Eukaryotic Cell;Excision;experimental study;Genetic;Goals;Health;Holoenzymes;human disease;Hydrolysis;Individual;inhibitor;inorganic phosphate;insight;Laboratories;Location;Malignant Neoplasms;Metals;Mitosis;Molecular;Molecular Chaperones;novel;novel strategies;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;Protein Dephosphorylation;Protein phosphatase;protein phosphatase inhibitor-1;Proteins;Reaction;Regulation;Research;Research Personnel;Research Project Grants;response;Role;Serine/Threonine Phosphorylation;Signal Transduction;structural biology;Structure;Substrate Specificity;Testing;Threonine Phosphorylation Site;tool;ubiquitin-protein ligase;Work;yeast genetics;Yeasts

PROJECT_TITLE: Protein Phosphatase 1 Holoenzyme Formation

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


PROJECT_TERMS: Address;Affect;Age;Biological Sciences;Brain;Brain imaging;Clinical Research;Communication;Communities;community engagement;Competence;Complement;Computer software;Data;Development;Diffuse;Discipline;Disease;Documentation;Education;Education and Outreach;Educational Materials;Educational process of instructing;Educational workshop;Equipment and supply inventories;Event;Exercise;experience;experimental study;Feedback;Fellowship;Fellowship Program;Fostering;Future;Goals;Home;improved;Institution;International;Investments;Laboratories;Learning;learning materials;Link;massive open online courses;Measurable;meetings;Mind;neuroimaging;neuroinformatics;new technology;online resource;open source;outreach;Persons;Phase;Physics;Polishes;Population;programs;quantum;Registries;Reporting;repository;Reproducibility;Research;Research Personnel;research study;Resources;Running;Scheme;Series;Services;social media;Societies;Structure;Students;success;symposium;Teaching Materials;Testing;Time;tool;Trainers Training;Training;Training Activity;Universities;Update;web site;Work

PROJECT_TITLE: ReproNim: A Center for Reproducible Neuroimaging Computation


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: FORT WORTH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: Endothelin receptors are proteins that are increased in the eyes with increased pressure as seen in glaucoma. In the current grant application, the process by which endothelin receptors contribute to the damage to the optic nerve will be studied at the level of the nerve cells in the eye. Endothelin receptors blockers will be tested to determine if they could protect nerve cells in the eye from dying due to elevated ocular pressure, and this could aid in the development of a repurposed medication, macitentan, for glaucoma treatment.

PI_NAMEs: KRISHNAMOORTHY, RAGHU R (contact)

PROJECT_TERMS: Address;Amino Acids;Animal Model;antagonist;Applications Grants;Aqueous Humor;Attenuated;Autophagocytosis;Axon;axon injury;axonal degeneration;bench to bedside;Binding;Bioenergetics;Blood Vessels;Cell Death;Cells;central retinal artery;Circulation;Confocal Microscopy;Data;defined contribution;Development;drug repurposing;Endothelin;Endothelin B Receptor;Endothelin Receptor;Endothelin Receptor Antagonist;Endothelin-1;Endothelin-2;Endothelin-3;Event;Eye;FDA approved;G-Protein-Coupled Receptors;Glaucoma;high resolution imaging;imaging study;Impairment;improved;Injections;innovation;Intervention;intravitreal injection;Knock-out;Laboratories;LAMP-1;LysoTracker;Mediating;Metabolic;Methods;Microspheres;Mitochondria;Molecular;Nerve Degeneration;Neurons;neuroprotection;novel;Optic Nerve;Oral;Organelles;Parkin;Patients;Peptides;Pharmaceutical Preparations;pharmacologic;pressure;Process;Publications;Quality Control;Rattus;Rattus norvegicus;receptor;Receptor Activation;Regulation;Reporting;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;Rodent;Rodent Model;Saline;Signal Transduction;System;Testing;Transgenic Mice;two-photon;ultra high resolution;Up-Regulation;vasoconstriction;Vision;Visual impairment

PROJECT_TITLE: Mechanisms underlying endothelin mediated neurodegeneration in glaucoma


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE  The nation continues to witness racially motivated encounters between the Black community and police officers. With 87% to 94% of Black youth reporting at least one event where they were racially discriminated against in the past year, Black justice-involved youth (JIY) are exposed to discrimination more often due to policing, placing them at an increased risk of engaging in alcohol and cannabis use as a means of coping with discrimination distress. In this project, Dr. Bryant aims to 1) examine the impact of racial discrimination on alcohol and other drug use, 2) create a culturally adapted substance use intervention for use with Black JIY, and 3) pilot the culturally adapted substance use intervention to assess changes in alcohol use and discrimination distress among Black JIY.

PI_NAMEs: BRYANT, BRITTANY  (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;adolescent alcohol and drug use;adolescent substance use;adverse outcome;Affect;Aggressive behavior;alcohol abuse therapy;alcohol and other drug;alcohol comorbidity;Alcohol consumption;alcohol effect;alcohol misuse;Alcohol or Other Drugs use;alcohol related consequences;alcohol risk;Anxiety;Applications Grants;Applied Research;Automobile Driving;Award;Awareness;Black race;Cannabis;career;career development;Caring;Clinical;clinical practice;Communities;community based research;coping;coping mechanism;Coping Skills;cost effective;Criminal Justice;culturally appropriate intervention;Data Analyses;Development;Discrimination;Distress;Drug usage;early onset;ethnic discrimination;ethnic disparity;Event;evidence base;Evidence based intervention;Exclusion;experience;Exposure to;externalizing behavior;Feasibility Studies;Feedback;Focus Groups;Foundations;gender difference;gender disparity;Goals;Health;improved;Individual;individualized medicine;Institutional Racism;Intervention;Justice;Knowledge;Law Enforcement;Lead;Learning;Light;Link;Manuals;marijuana use;member;Mental Depression;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;Mission;Modeling;Modification;National Institute on Alcohol Abuse and Alcoholism;negative affect;novel;Outcome;Outcome Study;Parents;Personal Satisfaction;Pharmaceutical Preparations;Phase;Police;Police officer;Policies;Population;prevent;probation;Procedures;Process;programs;Publications;Race;racial bias;racial discrimination;racial disparity;racial population;Randomized, Controlled Trials;recidivism;reduced alcohol use;reduced substance use;Reporting;Research;Research Methodology;Research Personnel;Risk;Series;skills;social health determinants;Strategic Planning;Stress;Stressful Event;substance use;substance use treatment;Symptoms;System;theories;Time;tool;Training;traumatic event;Treatment outcome;treatment program;underage drinking;United States National Institutes of Health;Violence;women of color;Youth

PROJECT_TITLE: Cultural Adaptation of an Alcohol and Other Drug Use Treatment for Black Justice Involved Youth

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Cancer;Clinical Research;Lymphatic Research;Precision Medicine;Prevention;Skin Cancer

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Even with the most recent therapeutic advances, metastasis remains the leading cause of death in patients with cancer. In virtually all solid tumors, metastasis occurs via the lymphatic circulation; however little is known about the factors that ultimately sculpt this process. Thus, in the current application we will seek to define critical, lymph-derived factors responsible for mediating pre-metastatic niche, immune downregulation in the tumor-draining lymph node in order to identify and develop both prognostic tools and therapeutic counter- measures capable of meaningful clinical impact in patients undergoing primary surgical resection of cutaneous malignant melanoma.

PI_NAMEs: MARKOVIC, SVETOMIR NENAD (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;Advanced Malignant Neoplasm;Algorithms;Biological;Biological Markers;Biopsy;cancer cell;cancer recurrence;Cancer Relapse;carcinogenesis;Cause of Death;Cells;Chronic;Climate;Clinical;clinical risk;clinically relevant;Complement;Cutaneous Melanoma;Data;Detection;Development;Diagnosis;digital;disabled;Disease;Down-Regulation;draining lymph node;Early Intervention;Excision;Excision biopsy;extracellular vesicles;follow-up;Fostering;Goals;Human;Image;imaging approach;imaging biomarker;imaging modality;Immune;immune function;Immune response;Immune System Diseases;Immunologic Surveillance;Immunologics;immunoregulation;Immunosuppression;Immunotherapy;improved;In Vitro;innovation;insight;Intercellular Fluid;Intervention;Knowledge;Laboratories;Liquid substance;Location;Lymph;Lymph Node Dissections;lymph nodes;Lymphatic;lymphatic circulation;Lymphatic System;lymphatic vessel;Machine Learning;Malignant Neoplasms;Mediating;Mediator;Melanoma;Melanoma Cell;Metastatic Melanoma;Metastatic Neoplasm to Lymph Nodes;Microanatomy;Micrometastasis;Modeling;multiplexed imaging;National Comprehensive Cancer Network;Natural History;Neoplasm Metastasis;neoplastic cell;novel;Operative Surgical Procedures;Pathologic;Patient risk;patient stratification;Patients;Pattern;predictive tools;preservation;Primary Neoplasm;Process;Prognosis;prognostic;Prognostic Factor;prognostic signature;prognostic tool;prognostic value;radiological imaging;Recommendation;Recurrence;Relapse;relapse risk;Risk;Risk Assessment;Risk Factors;risk prediction;risk stratification;S100A9 gene;Sentinel Lymph Node;Series;Signal Transduction;Site;Solid;Solid Neoplasm;Surveys;Systemic Therapy;Testing;Therapeutic;therapeutic target;Tissues;tool;Translating;tumor;tumor microenvironment;Tumor-Associated Process;Tumor-Derived;virtual;Work

PROJECT_TITLE: Quantitative assessment of pre-metastatic immune subversion as a risk factor for melanoma relapse


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Seventeen United States Veterans die by suicide each day. Nearly three-fourths of those Veterans die from firearm injury or poisoning, and many seek care in VA Emergency Departments (ED) prior to suicide attempts. In 2019, the VA began screening all Veterans seeking ED care for increased suicide risk. Interventions that promote firearm and medication safety are recommended for Veterans identified as at-risk. Our work will develop and test such an intervention for Veterans who seek care in VA EDs. We will interview at-risk Veterans who recently sought VA ED care to identify factors relevant to developing the intervention, and work with Veterans and VA healthcare staff to develop and test the intervention. Our safety intervention for Veterans with increased suicide risk is consistent with the VA 2018-2028 National Suicide Prevention Strategy, priority in preventing Veteran suicides, and focus on delivering Veteran-centered care.

PI_NAMEs: SIMONETTI, JOSEPH A (contact)

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Address;Adoption;Affect;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;care seeking;career;Caring;Child;Clinical;Communication;community setting;Consensus;contextual factors;Cultural Sensitivity;Development;Devices;efficacy testing;Elements;Emergency Care;Emergency Department patient;Ensure;Evaluation;evidence base;firearm access;Firearms;Focus Groups;follow-up;Funding;Future;Goals;Gun injury;health belief;Health Services Research;Healthcare;Individual;innovation;Institution;Intervention;intervention refinement;Interview;Knowledge;medication safety;Mentorship;Methodology;Methods;Modeling;motivational enhancement therapy;Outpatients;Participant;patient oriented;Perception;Persons;Pharmaceutical Preparations;Pilot Projects;Poisoning;population health;prevent;Prevention program;Prevention strategy;preventive intervention;Primary Care;Process;Protocols documentation;Public Health;Public Health Administration;Qualitative Methods;Recommendation;recruit;Research;research and development;Research Personnel;Research Priority;Risk;Safety;Sampling;screening;Self Efficacy;staff intervention;Structure;suicidal risk;Suicide;Suicide attempt;Suicide prevention;support tools;Techniques;Testing;therapy design;therapy development;Training;Treatment Efficacy;United States;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;willingness;Work

PROJECT_TITLE: Development and Testing of a Veteran-Centered Lethal Means Safety Suicide Prevention Intervention

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Heart Disease;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: We seek to understand how transthyretin (TTR) aggregates in humans, and which aggregate structures lead to the dysfunction and ultimately the death of post-mitotic tissue in the TTR amyloid diseases that primarily destroy the nervous system and kidneys vs those that compromise heart function. Understanding these aspects and the corresponding structure-proteotoxicity relationships would enable the development of novel therapeutic strategies, the establishment of early diagnostic biomarkers, and establish methods that quantify response to therapy. We will use a new imaging approach to take a fresh look at heart pathology to probe the 3D relationships between the non-native TTR structures, host molecules, and immune cells and we will also use new proteomic methods to characterize changes in the plasma proteome upon the onset of disease.

PI_NAMEs: KELLY, JEFFERY W (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: 3-Dimensional;Address;Affect;aging related;Alleles;Amyloid;Amyloid Fibrils;Amyloidosis;Antibodies;Atomic Force Microscopy;Automobile Driving;Autonomic nervous system;autosome;Binding;Biochemical;Biological;biomarker identification;Blood;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cells;Cessation of life;Clinical;Clinical Trials;Collaborations;Cryoelectron Microscopy;cytotoxicity;Development;Diagnosis;diagnostic biomarker;Disease;Dissociation;Drops;Early Diagnosis;Elderly;Endoplasmic Reticulum;Enzyme-Linked Immunosorbent Assay;Exercise Tolerance;Exhibits;Functional disorder;Funding;Genetic;Goals;Guanine Nucleotide Exchange Factors;Heart;heart cell;Heart failure;heart function;heart imaging;Hepatocyte;Human;Human Pathology;imaging approach;imaging modality;Immune;immune cell infiltrate;improved;Infiltration;Inflammatory;insight;Kidney;Kinetics;Lead;Link;Liver;Macrophage;male;Methodology;Methods;Minor;Molecular Chaperones;monomer;Morbidity - disease rate;mortality;mutant;Mutation;Nervous System;Neurons;non-Native;novel therapeutic intervention;Nucleotides;Onset of illness;Pathology;Pathway interactions;Patients;Peptides;Performance;Pharmaceutical Preparations;pharmacologic;Phenotype;Plasma;Polyneuropathy;Population;postmitotic;Prealbumin;prevent;Probability;Process;protein aggregation;Proteome;Proteomics;proteotoxicity;Research;response;Sampling;Structure;Testing;Tissue Banks;tissue degeneration;tissue tropism;Tissues;treatment response;Variant

PROJECT_TITLE: Probing the biochemical mechanism of amyloid disease

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Immunotherapy;Machine Learning and Artificial Intelligence;Patient Safety

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: 8. Project Narrative Adverse events pose a significant challenge to medical interventions (drugs, devices, other), and while there is a clear need for adverse event surveillance, the current methods are time-consuming, unsustainable, and miss most adverse event cases. The widespread adoption of electronic health records (EHRs), capturing medical data for the majority of US patients, presents an opportunity for sustainable adverse event surveillance via automated approaches. Strategies for identifying and characterizing patients experiencing adverse events has the potential to inform risk factor identification, prediction of adverse event development, and prognostication of patient outcomes, as well as lay a crucial stepping-stone for further progression of EHR-based phenotyping in biomedical informatics.

PI_NAMEs: TRAN, STEVEN DUC (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Address;Adoption;Adverse drug event;Adverse event;Algorithms;automated analysis;Award;biomedical informatics;Body System;Cancer Patient;career networking;checkpoint therapy;Clinical;Code;cohort;Complex;Consumption;Couples;Data;Data Analyses;Detection;Development;Devices;Diagnosis;Dimensions;Disease;disease diagnosis;disease phenotype;Electronic Health Record;Event;experience;Explosion;Fellowship;Goals;Graph;Health Care Costs;Healthcare;Human;Immune checkpoint inhibitor;immune-related adverse events;improved;informatics tool;interest;International Classification of Diseases;Intervention;Label;Laboratories;Length of Stay;machine learning algorithm;Manuals;Maps;Medical;Medical History;Methods;Mining;mortality;Nature;Neighborhoods;novel;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Physicians;Population;Procedures;prognostication;Recording of previous events;Reporting;Research;Risk Factors;Series;Site;skills;Techniques;Testing;text searching;Time;Time Series Analysis;time use;vector;Work;Writing

PROJECT_TITLE: AE2Vec: Medical concept embedding and time-series analysis for automated adverse event detection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering;Genetics;Microbiome

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Understanding the dynamics that govern whether a mutant allele will go extinct or establish and propagate its lineage in a growing population that is competing for nutrition and space is relevant to many biological settings. For example, biofilms in the human oral microbiome and pre-vascular tumors are dense populations of cells that expand spatially in a way that is remarkably similar to range expansions of the genetically-tractable model organism Saccharomyces cerevisiae presented in this work. By elucidating how the physical properties of cells and of microbial populations affect their growth and evolutionary dynamics, this work will shed light on the growth and evolutionary dynamics of dense, expanding cellular populations in general and develop null models that can be used to infer the presence and nature of biological interactions (e.g., mutualism or antagonism) based on observed spatial patterns within these biofilms.

PI_NAMEs: RANDOLPH, KATIE ELAINE (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: 3-Dimensional;Affect;Agar;Alleles;antagonist;Biological;Biological Models;Biophysics;Biotechnology;Birth;Cell Communication;Cell Density;cell growth;Cell Shape;Cells;Cicatrix;Collaborations;Communication;daughter cell;Dissection;Educational process of instructing;Ensure;Environment;Evolution;experimental study;Feedback;Fellowship;Gene Frequency;Genes;Genetic;genetic analysis;Genetic Drift;genome sequencing;Goals;Grant;Growth;Haploidy;Health;Height;Human;Human Microbiome;insight;Liquid substance;Measurement;Mechanics;Mentorship;Microbe;microbial;Microbial Biofilms;microbial colonization;microbial community;model organism;Modeling;mutant;Mutate;Mutation;mutualism;Natural Selections;Nature;Neoplasms in Vascular Tissue;nutrition;oral microbiome;Pattern;Phenotype;physical model;physical property;Population;Property;reconstruction;Research;research facility;Resources;Saccharomyces cerevisiae;Saccharomycetales;simulation;Site;Speed;Structure;Surface;Surface Tension;System;Technology;theories;Time;Training;trait;Viscosity;Visual;whole genome;Work

PROJECT_TITLE: Evolutionary adaptation of dense microbial populations to range expansion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-A(21)L]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Despite long-standing gender parity in the number of medical students, women remain underrepresented in the senior ranks of the physician-scientist workforce, and research suggests that the mid-career transition is a point at which many careers stall. We propose to test the impact of a novel peer mentorship intervention to promote the careers of women from a national mid-career cohort of biomedical clinician-researchers (recipients of new NIH K08 and K23 awards in 2006-2009) in the EMPOWER trial, which will compare outcomes, including advancement, productivity, and burnout, between women randomized to a control arm provided with curricular materials alone or an intervention arm provided with the same materials but also engaged in peer mentorship teams. This intervention will be modeled on the Leadership Learning Model Framework developed for the Executive Leadership in Academic Medicine Program, which is partnering with us in this work, and will be informed and refined based on the analysis of surveys and interviews to illuminate mechanisms driving gender differences in career outcomes in the post-#metoo era, including the impact of the intersection of gender with other categories of disadvantage such as race or sexual orientation.

PI_NAMEs: JAGSI, RESHMA  (contact)

PROJECT_TERMS: Address;Aptitude;Area;arm;Attention;Automobile Driving;Awareness;Baseline Surveys;Biomedical Research;burnout;career;career development;Career Mobility;Categories;Climate;Clinical;cohort;Compensation;design;Disadvantaged;Disparity population;Educational Curriculum;Endowment;Ensure;Ethnic Origin;Evidence based intervention;experience;Faculty;Female;follow-up;Future Generations;Gender;gender difference;gender disparity;gender equity;Glean;Grant;harassment;Home;Individual;Inequity;Influentials;insight;interest;intersectionality;Intervention;intervention refinement;Interview;Investments;K-Series Research Career Programs;Knowledge;Leadership;leadership development;Learning;learning materials;Lesbian Gay Bisexual Transgender Queer;Medical Students;Medicine;member;men;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;Modeling;Motivation;Movement;novel;Observational Study;Outcome;parity;Participant;peer;peer coaching;Perception;Physicians;Policies;Population;Positioning Attribute;Productivity;programs;Publications;Qualitative Methods;Race;Randomized;randomized trial;Recording of previous events;Reporting;Research;Research Personnel;Resources;Respondent;Sampling;Scientist;Sex Orientation;Sexual Harassment;Societies;Specific qualifier value;success;Survey Methodology;Surveys;Talents;Testing;therapy design;therapy development;Time;treatment arm;trial design;United States National Institutes of Health;Update;videoconference;Woman;Women's cohort;Work

PROJECT_TITLE: Peer Mentoring to Overcome Obstacles for Midcareer Women Clincian-Scientists in Academic Medicine

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative We have recently associated telomere biology disorders (TBD) and gain-of-function germline RPA1 mutations. The molecular and functional consequences of these mutations on telomere maintenance and hematopoiesis is not understood. The proposed studies will use biochemical methods and iPSC disease model to establish the molecular mechanism by which gain-of-function RPA1 mutations cause telomere dysfunction while using in vivo murine system to determine the functional consequence.

PI_NAMEs: SHARMA, RICHA  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Affinity;animal resource;Area;Award;Binding;Binding Proteins;Biochemical;Biological;Biological Assay;Biology;Bone marrow failure;career;career development;causal variant;Cell division;Cell Maintenance;Cell Separation;Cells;cellular imaging;Childhood;Chromosomes;Clinical;clinical care;clinical phenotype;Complex;CRISPR/Cas technology;Cytogenetics;Data;Development Plans;Digestion;Disease;disease model;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA Repair Disorder;DNA Repair Gene;Educational workshop;Ensure;Exhibits;experience;Faculty;Family;Flow Cytometry;Functional disorder;gain of function;gene therapy;Generations;Genes;Genetic Induction;genetic pedigree;Genome;Genome engineering;Germ Lines;Goals;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Heterogeneous-Nuclear Ribonucleoproteins;Heterozygote;Human;imaging facilities;Immunoprecipitation;Impairment;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inherited;Institution;K-Series Research Career Programs;lectures;Length;light microscopy;Liver Cirrhosis;Location;Maintenance;Maps;Mass Spectrum Analysis;Mentors;Methods;Missense Mutation;Molecular;Mosaicism;mouse model;Multiprotein Complexes;Mus;mutant;Mutation;novel;Nuclear Proteins;nuclease;Organ;Orthologous Gene;Pathogenesis;Pathologic;Pathology;Patient-Focused Outcomes;Phenotype;Physicians;premature;preservation;proband;Process;Prognosis;Proteins;Proteome;Proteomics;Publishing;Pulmonary Fibrosis;recruit;repaired;replication factor A;replication factor C;replication stress;Research;Research Support;Resource Sharing;response;Role;S phase;Saint Jude Children's Research Hospital;Scientist;segregation;Single-Stranded DNA;skills;stem;stem cell model;stem cells;Stress;success;System;Telomerase;telomere;Telomere Maintenance;Telomere Shortening;Testing;Time;Tissue imaging;Variant

PROJECT_TITLE: Consequences of gain-of-function RPA1 mutations on telomere function and hematopoiesis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE  The proposed research aims to design and apply a novel polymeric artificial antigen presenting cell (aAPC) platform for the in vivo expansion of tumor-specific CD8+ T cells for cancer immunotherapy, circumventing critical hurdles that currently hamper the success of adoptive T cell therapies. Using this particulate platform, we will investigate several significant physicochemical and immunological factors that influence antigen-specific T cell activation. By adapting our technology to both murine and human systems, we will demonstrate the clinical relevance of this technology.

PI_NAMEs: SHANNON, SYDNEY ROSE (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Acids;Adoption;Adoptive Cell Transfers;Adoptive Transfer;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Autologous;Biocompatible Materials;biocompatible polymer;biodegradable polymer;Biological;Biological Process;Biomimetics;cancer immunotherapy;Cancer Model;Cancer Patient;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Physiology;Cells;chemokine;Clinical;clinical translation;clinically relevant;Complex;cost;cost effective;Couples;Cues;cytokine;cytotoxic;cytotoxicity;Dendritic Cells;density;design;Development;Encapsulated;Engineering;Esters;exhaustion;experimental study;Formulation;Generations;Glycolates;Goals;handicapping condition;Human;Immunologic Factors;Immunologics;Immunotherapy;improved;In Vitro;in vivo;Incubated;Injections;insight;Interleukin-12;Interleukin-15;Interleukin-2;interleukin-21;Licensing;long term memory;Maintenance;manufacturing cost;Melanoma;Membrane Proteins;Memory;Methods;Modeling;Mus;neoplastic cell;novel;particle;Particulate;Patients;Phenotype;Polymers;Price;Process;Property;Proteins;Reduce health disparities;Research;response;Safety;Signal Transduction;success;Supporting Cell;System;T cell differentiation;T cell response;T cell therapy;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Technology;Testing;Therapeutic Uses;Transgenic Organisms;Treatment Efficacy;tumor;Tumor Burden;Tumor Expansion;Work

PROJECT_TITLE: Tri-Signal Artificial Antigen Presenting Cells for Cancer Immunotherapy


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Prevention;Rare Diseases;Rural Health;Social Determinants of Health

PHR: PROJECT NARRATIVE Rural cancer survivors, particularly those with blood cancers, are at increased risk for cancer related financial hardship that can have a negative impact on quality of life and lead to poor health outcomes. This study aims to explore the experience of cancer related financial hardship for people with Chronic Myeloid Leukemia (CML) who live in the rural Southeast and healthcare team member perceptions of the rural CML patient experience of financial hardship. This study will address a gap in the literature for an at risk population that is challenged by the costs of cancer care while providing evidence that will lead to rural specific intervention development to reduce the risk of financial hardship and improve health outcomes and quality of life for rural cancer patients.

PI_NAMEs: WRIGHT, STEPHANIE LEE (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Address;Affect;Age;Area;Award;cancer care;cancer diagnosis;Cancer Patient;cancer risk;Cancer Survivor;care costs;career;Caring;Chronic;Chronic Myeloid Leukemia;Clinical;Clinical Trials;Code;Coping Behavior;cost;County;Data;Diagnostic;Disparity population;Distress;distrust;Education;Employment;Ethnic Population;experience;Face;Fellowship;Female;Financial Hardship;financial toxicity;Gender;Health;Health care facility;health equity;health inequalities;Health Insurance;Health Services;Healthcare;Hematopoietic Neoplasms;high risk population;improved;Individual;Inequity;Infrastructure;Insurance Coverage;Intervention;Interview;leukemia treatment;Life Expectancy;life span;Link;literacy;Literature;low health literacy;Low income;low socioeconomic status;Malignant Neoplasms;Measures;Medical;Medical Care Team;medication nonadherence;member;mortality;National Institute of Nursing Research;Nurses;Oncology;Outcome;Participant;Patients;Perception;Persons;Pharmaceutical Preparations;Pharmacists;poor health outcome;Population;Populations at Risk;Provider;psychologic;Quality of life;racial minority population;Recommendation;recruit;Reporting;Research;Resources;response;Risk;Risk Factors;Risk Reduction;Rural;rural area;Rural Community;rural healthcare;rural patients;Rural Population;Services;social health determinants;Social Workers;sociodemographics;Strategic Planning;Stress;Structure;System;therapy development;Time;Training;Travel;treatment duration;Tyrosine Kinase Inhibitor;Underinsured;Uninsured;Uninsured Medical Expense

PROJECT_TITLE: The Experience of Cancer Related Financial Hardship Among Individuals with Chronic Myeloid Leukemia in the Rural Southeast

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(86)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Large scale, multi-platform genomic projects in translational studies are often difficult to accomplish by individual laboratories. Collaborate team science networks, like The Cancer Genome Atlas and the Genome Data Analysis Network, bring together researchers with varied expertise to generate, analyze, and provide the data back to the research community for larger use and impact. We propose to provide expertise in RNA sequencing, spatial genomics, data integration, and clinical outcomes analysis as a Genome Data Analysis Center in support of the Genome Data Analysis Network.

PI_NAMEs: HAYES, DAVID N;HOADLEY, KATHERINE A. (contact)

PROGRAM_OFFICER_NAME: YANG, LIMING

PROJECT_TERMS: Address;Adopted;American Association of Cancer Research;analytical tool;Area;Artificial Intelligence;Automobile Driving;Award;Awareness;B-Lymphocytes;Back;bench to bedside;Biological Assay;Biological Markers;Blood capillaries;cancer classification;Candidate Disease Gene;career;Center for Translational Science Activities;Characteristics;Classification;Clinical;Clinical Trials;Clinical Trials Cooperative Group;Collaborations;Color;Communities;Companions;Competence;Complex;Contracts;Data;Data Analyses;Data Commons;data integration;data sharing;Disease;DNA;DNA sequencing;Emerging Technologies;Epigenetic Process;Event;Evolution;experience;Explosion;Gene Expression Profile;Gene Fusion;Generations;Genetic Fingerprintings;genetic signature;Genetic Transcription;Genome;Genome Data Analysis Center;Genome Data Analysis Network;Genomic approach;genomic data;genomic platform;Genomics;Genotype;Goals;hazard;Head and Neck Cancer;Heterogeneity;Immunogenomics;improved;Individual;innovation;invention;Knowledge;Laboratories;Leadership;Malignant Breast Neoplasm;Malignant Neoplasms;manufacture;Manuscripts;Maps;Messenger RNA;Methods;MicroRNAs;Modeling;Molecular;molecular subtypes;Morphology;Mutation;nano-string;neural network;next generation;next generation sequencing;novel;Oligonucleotide Microarrays;Outcome;Paraffin;Pathogenesis;Patient Care;Patients;petabyte;Phenotype;Play;precision medicine;Production;Productivity;programs;Proteins;Proteomics;Quality Control;Recording of previous events;Recurrence;Reporting;Research;Research Personnel;response;Rewards;RNA;RNA analysis;RNA Splicing;Role;Sampling;Science;skills;Slide;Somatic Mutation;T-Cell Receptor;T-Lymphocyte;technique development;Techniques;Technology;The Cancer Genome Atlas;Tissues;tool;transcriptome sequencing;transcriptomics;Translational Research;translational study;treatment response;tumor;tumorigenesis;U-Series Cooperative Agreements;Variant;variant detection;Viral;viral detection;viral RNA;Visualization;Work

PROJECT_TITLE: Specialized RNA analysis center for integrative genomic analyses


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative iPSC are increasingly utilized in disease modeling, drug discovery, toxicological testing, and clinical applications and the need for high quality, well characterized biomaterials is clear and pressing. The NHCDR and RUCDR will continue to serve the global scientific community by providing source cells, iPSC and isogenic iPSC pairs from subjects with neurological disorders such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, amyotrophic lateral sclerosis, Dystonia and Frontotemporal Degeneration.

PI_NAMEs: MOORE, JENNIFER C;TISCHFIELD, JAY ARNOLD (contact)

PROGRAM_OFFICER_NAME: PRICE, REBECCA CHRISTINE

PROJECT_TERMS: Adult;Age;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Automation;biobank;Biocompatible Materials;Biological Products;Blood;Blood Cells;Catalogs;cell bank;Cell Line;Cell model;cell repository;cell type;Cells;Central Nervous System Diseases;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Communities;Consultations;Data;Data Coordinating Center;data management;data repository;Databases;Derivation procedure;design;Development;Disease;disease model;Disease Progression;DNA;Documentation;drug discovery;drug use screening;Dystonia;Embryo;Ensure;Ethics;exhibitions;Exhibits;Family member;Fibroblasts;flexibility;Foundations;frontotemporal degeneration;Gene Modified;Generations;Genetic;Genetic Research;Genetic Variation;genome editing;genome integrity;Genotype;Goals;high standard;Human;Human Cell Line;Human Development;human disease;Human Genetics;human induced pluripotent stem cells;Human Resources;human subject;Huntington Disease;improved;Individual;induced pluripotent stem cell;innovation;Instruction;interest;International;Internet;Lymphocyte;Maintenance;material transfer agreement;medical schools;meetings;Methodology;Mission;Modification;National Institute of Neurological Disorders and Stroke;nerve stem cell;Nervous System Disorder;Neurodegenerative Disorders;Neurons;news;online repository;operation;Parkinson Disease;Pluripotent Stem Cells;Policies;Price;Privacy;Privatization;Process;Production;prospective;Protocols documentation;quality assurance;Quality Control;Reporter;repository;Research;research and development;Research Personnel;Resources;sample collection;Sampling;Scientific Advances and Accomplishments;search engine;Secure;Services;sex;Shipping;Site;Skin;skin biopsy;Somatic Cell;Source;stem cell genes;Stem Cell Research;stem cells;System;Technology;Testing;therapeutic development;Time;Tissue Sample;tool;Toxicology;Trust;U-Series Cooperative Agreements;United States National Institutes of Health;Universities;user-friendly;Validation;volunteer;Washington;web app;Work

PROJECT_TITLE: NINDS Human Cell and Data Repository (U24)


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cerebrovascular;Neurosciences;Substance Misuse

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Alcohol-induced blackouts, a form of amnesia that involves a region of the brain termed hippocampus, frequently occur upon moderate-heavy, acute alcohol consumption disregarding age, alcohol drinking history, biological sex, gender or education, and leads to risky behaviors including vandalism, unprotected and/or unconsented intercourse, and driving an automobile while intoxicated. Despite the damage to individuals and society that alcohol-induced blackouts impose, Medicine has fallen short in understanding the mechanisms of their occurrence and in providing pharmacotherapeutics to counteract them. Departing from all previous work, which focused on mechanisms operating within hippocampal neurons, this study proposes a hippocampal vascular mechanism for the condition and thus, will: (a) identify the molecular target in the brain arteries that facilitates the occurrence of alcohol-induced blackouts, (b) address its likely contribution to the differences in alcohol-induced blackout between biological sexes, and (c) establish the efficacy of endothelium-independent vasodilators newly discovered by our group to selectively affect the vascular target of alcohol and thus counteract alcohol-induced blackouts.

PI_NAMEs: DOPICO, ALEX M. (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: 4-Aminopyridine;Abbreviations;Acute;Address;Affect;Age;Alcohol consumption;alcohol exposure;Alcoholic Intoxication;Alcohols;Amino Acids;Amnesia;analog;Arteries;Automobile Driving;Behavioral;binge drinking;biological sex;Biomedical Research;Blood alcohol level measurement;Blood flow;Blood Vessels;Brain;brain circulation;Brain region;Cell Respiration;Cells;Cephalic;cerebral artery;cerebrovascular;Chronic;Circle of Willis;Circulation;Complex;Computer Models;constriction;Data;Dependence;Diameter;Dilator;dimer;Docking;drinking;drug action;Education;Electroporation;Endothelium;Engineering;Ethanol;Evaluation;experimental study;Family;Functional disorder;Gender;High Prevalence;Hippocampus;Human;Impairment;In Vitro;in vivo;Individual;Intoxication;Ion Channel;Ischemia;Knock-out;Knowledge;large-conductance calcium-activated potassium channels;Ligands;Link;Lipids;Mammals;Manuals;Mediating;Medicine;Membrane;Memory;Memory impairment;Metabolic;middle cerebral artery;Molecular;Molecular Target;mouse model;Mus;Muscle Cells;Mutagenesis;nano;Neuronal Dysfunction;Neurons;neurovascular;novel;Organ;Paper;patch clamp;Pathology;Perforation;Pharmacology;pharmacophore;Phosphorylation;Physiological;Probability;Process;Protein Isoforms;Proteins;Recombinant DNA;Recombinants;Recording of previous events;Resolution;response;Risk Behaviors;Robotics;Rodent Model;Role;Scanning;Side;Site;Smooth Muscle;Smooth Muscle Myocytes;Societies;Stroke;Tail;targeted agent;Testing;theories;Tissues;Transmembrane Domain;vandalism;Vascular Smooth Muscle;vasoconstriction;Vasodilation;Vasodilator Agents;Voltage-Gated Potassium Channel;Whole-Cell Recordings;Work

PROJECT_TITLE: Ethanol actions on slo channels from arteries vs. brain.

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Prevention

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Colorectal cancer (CRC) is the second leading cause of cancer mortality globally and understanding the microbiota contributions to disease development is predicted to lead to new approaches to CRC prevention and therapy. In this proposal, using a murine model, I will define how genetic loss of adenomatous polyposis coli (Apc), a CRC driver mutation present in at least 80% of CRC, modulates the microbiome throughout the time course of colorectal tumor development. I expect my results to provide support in the future for innovation in CRC patient care.

PI_NAMEs: DZIEROZYNSKI, LINDSEY  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;adenoma;Adherence;anti-cancer research;APC gene;APC mutation;Area;Attention;Automobile Driving;Benign;Biology;Cancer Etiology;cancer risk;cancer therapy;carcinogenesis;Carcinoma;Cessation of life;Characteristics;Chronology;Colitis;Colon;colon cancer patients;colon microbiota;colon tumorigenesis;Colorectal Cancer;colorectal cancer prevention;colorectal cancer progression;Colorectal Neoplasms;Data;Development;Diagnosis;Disease;DNA Damage;DNA Sequence Alteration;driver mutation;dysbiosis;Early identification;Environment;Epithelial Cells;Epithelium;Event;fecal microbiome;Future;Gene Expression Regulation;Genetic;Germ-Free;Goals;Habitats;Hand;Histopathology;host microbiome;Human;Individual;Inflammatory Bowel Diseases;innovation;insight;Laboratory Finding;Lesion;Malignant Neoplasms;Measures;member;men;Metabolic Pathway;metabolomics;Microbe;microbial;microbial colonization;microbial composition;Microbiology;microbiome;microbiome composition;microbiota;Modeling;mortality;mouse model;Mucositis;Mucous Membrane;Mus;Mutate;Mutation;novel;novel strategies;pathogen;Pathogenesis;Pathogenicity;Patient Care;permissiveness;Prevention;Proliferating;Research;resident commensals;Spatial Distribution;Testing;Therapeutic;Time;time use;Tissues;transcriptome sequencing;transcriptomics;tumor;tumor microbiome;tumor microenvironment;tumor progression;Tumor Suppressor Genes;tumorigenesis;tumorigenic;Woman

PROJECT_TITLE: Defining the changing microbiome composition and host-microbe mechanistic effects following Apc inactivation during colorectal cancer pathogenesis


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Attentional deficits are present in patients suffering from neurodegenerative diseases and neuropsychological disorders. In fact, these attentional deficits manifest prior to the cardinal symptoms of such conditions, such as dementia, traumatic brain injury, and schizophrenia (Sharma et al., 2016). Thus, developing a framework for studying the systematic underpinning of cognitive processes, such as attention, may serve to improve the detection of cognitive markers for preclinical diagnostics of these neurological conditions (Levy et al., 2016).

PI_NAMEs: GONZALEZ-AMORETTI, JOHN CARL (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Affect;Area;area V4;aspirate;Attention;Attentional deficit;attentional modulation;Behavioral;Brain;Brain region;career;Chronic;Classification;Code;Cognitive;cognitive process;Communication;Communities;covert attention;Dementia;design;Detection;Diagnostic;Disease;Environment;Exhibits;Fellowship;Fostering;frontal eye fields;GABA Agonists;Goals;Implant;improved;Individual;inferotemporal cortex;Knowledge;Lead;Learning;Location;Mediating;Mental disorders;Monkeys;Motor;multi-electrode arrays;Muscimol;Nature;Neurodegenerative Disorders;Neurologic;Neurons;neurophysiology;Neuropsychology;outreach;Patients;Perception;pharmacologic;Physiological;Population;Population Analysis;Positioning Attribute;pre-clinical;Prefrontal Cortex;Process;Property;Reaction Time;Reporting;Research;Resolution;response;Response Latencies;Role;Saccades;Sampling;Schizophrenia;signal processing;Signal Transduction;skills;Social Environment;spatiotemporal;Stimulus;Symptoms;Training;Traumatic Brain Injury;United States National Institutes of Health;Visual;Visual attention;visual control;visual motor;visual processing;visual search;Visuospatial;Work

PROJECT_TITLE: NIH Gonzalez-Amoretti Characterizing PopulationDynamics of Prefrontal Cortex which Govern the Modulation of Visual Processing


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Precision Medicine;Prevention;Rare Diseases

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Assessment of treatment response for hepatocellular carcinoma (HCC) is often difficult and inaccurate due to treatment-related non-specific changes on imaging tests. The study aims to investigate the performance of novel circulating biomarkers (EV digital score, GALAD score, HCC EV-GALAD digital score) for evaluation of HCC treatment response. These circulating biomarkers will be rapidly translatable and may prevent unnecessary frequent imaging tests by providing an accurate assessment of HCC treatment response.

PI_NAMEs: YANG, JU DONG  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Ablation;Address;Aftercare;Applications Grants;Area Under Curve;Award;Bioinformatics;Biological Assay;Biological Markers;Biology;biomarker development;biomarker discovery;biomarker panel;Biometry;Biotechnology;California;cancer epidemiology;Cancer Etiology;cancer therapy;career;career development;Cessation of life;Chemoembolization;circulating biomarkers;Clinical;clinical practice;clinical translation;Communication;Complement;Couples;Data;Data Analyses;Detection;Development;Diagnosis;digital;Digital biomarker;Doctor of Medicine;Doctor of Philosophy;Early Diagnosis;Enrollment;Evaluation;evaluation/testing;extracellular vesicles;Faculty;Funding;Gastroenterology;Goals;Grant;Health Sciences;Hepatology;Histologic;Image;Image Analysis;innovation;Leadership;liquid biopsy;Los Angeles;machine learning algorithm;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Medical center;Mentors;Messenger RNA;Modality;Motivation;nanotechnology platform;Nature;news;novel;novel marker;Paper;participant enrollment;Patient Monitoring;Patient Recruitments;Patients;Performance;Phase;Physicians;precision medicine;Prediction of Response to Therapy;prevent;Prevention;Primary carcinoma of the liver cells;professor;Prognosis;prospective;Proteins;Prothrombin;Publishing;radiological imaging;Radiology Specialty;Research;Research Project Grants;Reverse Transcription;RNA;Sampling;Scientist;Screening for cancer;Serum;Serum Proteins;skill acquisition;skills;System;Technology;Testing;Training;transcriptomics;Translating;treatment response;tumor;Tumor Burden;Tumor Markers;Universities;Writing;α-Fetoproteins

PROJECT_TITLE: Novel circulating biomarker digital scores for assessing treatment response in liver cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: CENTER OVERVIEW PROJECT NARRATIVE The Pediatric Center of Excellence in Nephrology at the Children’s Hospital of Philadelphia (CHOP PCEN) will continue to facilitate extensive collaborative research around the causes, diagnoses, and treatment of kidney diseases in children and break down barriers to clinical trials implementation. The CHOP PCEN will continue to partner with PEDSnet through the Learning Health System (LHS) Core leveraging the resources of a national interconnected, multi- institutional infrastructure focused on childhood kidney disease and establish a new core, the Molecular Precision Nephrology (MPN) Core to facilitate identification of novel molecular targets to expand therapeutic options for children with kidney disease. The Administrative Core will support the Enrichment Program and Opportunity Pool Pilot and Feasibility Program as well as two Research Projects that apply innovative approaches to the data resources of the LHS Core and NIDDK consortia.

PI_NAMEs: DENBURG, MICHELLE  (contact);FURTH, SUSAN L.

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Acceleration;Acute;acute care;Address;Adult;Atlases;base;Bioinformatics;Biometry;Cells;Child;Childhood;Chronic;Chronic Kidney Failure;Clinical;Clinical effectiveness;clinical phenotype;Clinical Practice Guideline;Clinical Research;clinical trial implementation;Clinical Trials;Clinical Trials Design;cohort;Collaborations;comparative effectiveness;Comparative Effectiveness Research;comparative effectiveness study;comparative effectiveness trial;computable phenotypes;Consultations;Core Facility;Data;Data Element;data quality;data resource;Data Science;Dedications;design;Diagnosis;Disease;Disease Progression;Disease remission;Educational Status;Effectiveness;epigenome;Evaluation;Event;evidence base;Faculty;Family;Fluid Balance;Focal and Segmental Glomerulosclerosis;Fostering;Foundations;Fracture;Funding;Generations;Health system;Human;improved;Infection;Infrastructure;innovation;Institution;Intervention;Kidney;Kidney Diseases;Learning;Maps;Mentors;Methodology;Methods;Mission;Molecular;molecular phenotype;Molecular Target;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;nephrogenesis;Nephrology;new therapeutic target;Normal saline;novel;Observational Study;Outcome;Outcomes Research;Pathogenesis;Patients;pediatric department;Pediatric Hospitals;Pennsylvania;phenotyping algorithm;Philadelphia;Pragmatic clinical trial;pragmatic trial;Process;programs;Proteinuria;Proteome;Recurrence;Research;Research Design;Research Institute;Research Methodology;Research Personnel;Research Project Grants;Resources;Risk Reduction;Sampling;Sepsis;Services;skeletal;Structural Models;Testing;Therapeutic;therapeutic target;Time;Tissue Banks;Tissue Sample;tool;Translations;treatment effect;Universities;virtual;Work;young adult

PROJECT_TITLE: CHOP Pediatric Center of Excellence in Nephrology


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Kidney Disease;Pediatric

PI_NAMEs: DENBURG, MICHELLE  (contact)

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Awareness;base;Basic Science;Big Data;Biological;Biomedical Research;career;career development;Child;Childhood;Clinical Data;clinical investigation;clinical phenotype;Clinical Research;clinical trial implementation;Clinical Trials;Clinical Trials Design;cohesion;Collaborations;Communities;community engagement;comparative effectiveness;Comparative Effectiveness Research;comparative effectiveness trial;Data;design;Development;Education;Effectiveness;Electronic Health Record;Epidemiology;evidence base;experience;Faculty;Family;Feasibility Studies;Fostering;Foundations;Future;genomic profiling;Goals;Health Services Research;Health system;human subject protection;human tissue;improved;Individual;Informatics;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;International;Kidney Diseases;Knowledge;Leadership;Learning;Longevity;medical schools;meetings;member;Mentors;Methods;Mission;Molecular;molecular phenotype;Multi-Institutional Clinical Trial;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;new therapeutic target;novel;Observational Study;organizational structure;Outcome;Patients;Pediatric Hospitals;Peer Review;Pennsylvania;Philadelphia;Pilot Projects;Policies;Positioning Attribute;Pragmatic clinical trial;pragmatic trial;prevent;Productivity;programs;Records;Research;Research Methodology;Research Personnel;Research Project Grants;Sampling;Scholars Program;skills;success;Talents;Therapeutic;Training;transcriptomic profiling;Translational Research;Universities;virtual;Vulnerable Populations;web site;Work

PROJECT_TITLE: Administrative Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: Program Narrative The Integrative Cancer Scholars (ICS) training program is an innovative comprehensive plan to prepare the next generation of cancer researchers by emphasizing critical thinking skills, adapting novel technologies and requiring a co-mentoring plan with clinical and basic science faculty mentors. The development of innovative and impactful therapies must integrate information from clinical experience and fundamental discoveries of basic science to understand and act on the abnormal transformations of key molecules or pathways in cancer. ICS trainees are expected to produce original, creative and significant cancer research and have advanced communication skills for dissemination of their discoveries.

PI_NAMEs: CAREW, JENNIFER S (contact);CURIEL-LEWANDROWSKI, CLARA ;ROGERS, GREGORY CHARLES

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Grant;Malignant Neoplasms;Training

PROJECT_TITLE: Integrative Cancer Scholars Training Grant

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Health Services;Kidney Disease;Pediatric;Rare Diseases

PI_NAMEs: HANIEH, RAZZAGHI  (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;Affect;Architecture;Autosomal Recessive Polycystic Kidney;Award;Biological Models;blood pressure control;catalyst;Child;Child Health;Childhood;Chronic Kidney Failure;Clinical;Clinical effectiveness;clinical encounter;Clinical Research;Collaborations;comparative effectiveness;Comparative Effectiveness Research;Complement;computable phenotypes;Consultations;Data;Data Element;data quality;data resource;Data Science;Databases;Dedications;design;Development;Diagnosis;Dialysis procedure;Disease Progression;Effectiveness;Electronic Health Record;electronic health record system;Ensure;Epidemiology;epidemiology study;Evaluation;Family;Focal and Segmental Glomerulosclerosis;forging;Funding;Generations;Goals;Health;health data;Health Services Research;Health system;Henoch-Schoenlein Purpura;improved;Individual;Informatics;Infrastructure;insight;Institution;Intervention;Kidney;kidney biopsy;Kidney Calculi;Kidney Diseases;kidney preservation;Kidney Transplantation;Leadership;Learning;Lupus Nephritis;medical specialties;member;Methodology;Natural History;Nephritis;Nephrology;Nephrotic Syndrome;observational cohort study;Observational Study;Outcome;patient engagement;Patient Outcomes Assessments;Patient-Focused Outcomes;Pediatric Hospitals;Philadelphia;point of care;Pragmatic clinical trial;privacy preservation;process improvement;Program Reviews;Protocols documentation;query tools;Randomized Controlled Clinical Trials;Recording of previous events;recruit;Recurrence;Registries;Renal function;Renal glomerular disease;Reporting;Research;Research Personnel;research study;Resources;Rheumatology;routine care;Services;Site;skeletal;Specificity;structured data;success;Surveys;Time;Translations;Treatment Effectiveness;Update;Urology;Work

PROJECT_TITLE: Learning Health System Core


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project narrative: This project will generate connectional diagrams of the monkey and human brain at unprecedented resolutions. These diagrams will be linked both to the neuroanatomic literature and to in vivo neuroimaging techniques, bridging between the rigor of the former and the clinical relevance of the latter. The data to be generated by this project will advance our understanding of brain circuits that are implicated in motor and psychiatric disorders, and that are targeted by deep-brain stimulation to treat these disorders.

PI_NAMEs: HABER, SUZANNE N;HILLMAN, ELIZABETH M. C.;YENDIKI, ANASTASIA  (contact)

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TERMS: 3-Dimensional;Anatomy;Area;Autopsy;Axon;Biological Markers;Brain;Cells;Censuses;Clinical;clinically relevant;Cohort Studies;Collection;Communities;comparative;Complex;connectome;Data;data acquisition;Data Analyses;data dissemination;data integration;data repository;Data Set;Deep Brain Stimulation;Dictionary;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Dystonia;Fascicle;Fiber;Funding Opportunities;Gilles de la Tourette syndrome;Goals;Human;human disease;Image;imaging biomarker;improved;in vivo;Individual;Injections;innovation;Internal Capsule;Label;Learning;Light;Link;Literature;Macaca;Magnetic Resonance Imaging;Maps;Measurement;Mental disorders;Methods;microCT;Microscopic;Microscopy;Modeling;Monkeys;Motor;motor disorder;Multimodal Imaging;multimodality;neural circuit;Neuroanatomy;neuroimaging;neuroregulation;new technology;non-invasive imaging;novel;novel imaging technology;Obsessive-Compulsive Disorder;Optical Coherence Tomography;Osmium;Parkinson Disease;Pathway interactions;Phase;Prefrontal Cortex;Protocols documentation;quality assurance;Records;Reproducibility;Research;Resolution;Sampling;segregation;sharing platform;side effect;Signal Transduction;Software Tools;Specimen;Stains;Structure;Structure of subthalamic nucleus;submicron;System;Techniques;technology validation;Testing;therapy outcome;Three-Dimensional Imaging;tomography;tool;Tracer;tractography;Training;Travel;ultra high resolution;Validation;vector;white matter

PROJECT_TITLE: BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Human Genome;Kidney Disease;Pediatric

PI_NAMEs: SUSZTAK, KATALIN  (contact)

PROJECT_TERMS: Acute;analytical method;APOL1 gene;Atlases;base;Basophils;Biochemical;Bioinformatics;Biopsy Specimen;Cell Communication;Cell Lineage;cell type;Cells;Child;Childhood;Chromatin;Clinical;Clinical Trials;community engagement;computerized data processing;computerized tools;Data;data acquisition;Data Set;Databases;Dedications;Descriptor;Development;Diagnostic Procedure;Disease;disease-causing mutation;epigenome;ethnic diversity;Fostering;Freezing;Future;Gene Expression;Generations;Genes;Genetic;genome-wide;Genotype;Goals;Heterogeneity;high risk;Histologic;Human;human disease;improved;Kidney;kidney biopsy;kidney cell;Kidney Diseases;kidney fibrosis;Maps;Measurement;Methods;Molecular;Monitor;multimodality;multiple omics;Mus;nephrogenesis;Nephrology;novel;Nuclear;Nucleotides;Pathway interactions;Pediatrics;personalized diagnostics;pharmacologic;Phase;Phenotype;Population Heterogeneity;Process;Prognosis;protective pathway;Proteome;reconstruction;Recording of previous events;Regulation;renal ischemia;repaired;Research;Resolution;Resources;RNA;Role;Sampling;sensor;single cell analysis;single nucleus RNA-sequencing;single-cell RNA sequencing;spatial integration;Therapeutic;therapeutic development;therapeutic target;Tissue Banks;Tissue Embedding;Tissue Sample;tool;treatment response

PROJECT_TITLE: Molecular Precision Nephrology Core


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: IOWA CITY

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative: Cochlear implants represent the most successful neuroprosthesis in clinical use, providing direct electrical stimulation to the auditory nerve to restore hearing to deaf patients. However, cochlear implant recipients usually struggle to understand complex auditory signals such as speech in noise and music. These studies seek to develop and understand novel thin film coatings applied to the implant to diminish trauma and scarring in the cochlea, improve the interface of the implant with the cochlear tissues, and enhance the ability of cochlear implants to represent complex auditory signals.

PI_NAMEs: GUYMON, ALLAN ;HANSEN, MARLAN R (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: 3-Dimensional;Acoustic Nerve;Acoustics;Adhesions;Auditory;Bacteria;Bacterial Adhesion;Biocompatible Materials;Biological;Cadaver;capsule;Cell Adhesion;Cells;Chemicals;Cicatrix;Clinical;Cochlea;Cochlear Implants;combat;Complex;crosslink;Data;deaf;density;Development;Devices;Dexamethasone;Drug Delivery Systems;Effectiveness;electric impedance;Electric Stimulation;Electrophysiology (science);Engineering;Equilibrium;Fibrosis;Film;flexibility;Foreign Bodies;Fracture;Friction;functional improvement;Funding;Glucocorticoids;Glycolates;Health;Hearing;hearing impairment;hearing restoration;Histologic;Housing;Human;Hydrogels;Implant;implant coating;implant material;implantation;Implanted Electrodes;improved;Inflammation;Inflammatory;Kinetics;learning materials;Legal patent;Masks;Measures;mechanical properties;Mechanics;Medical Device;medical implant;Membrane Proteins;Methods;Microspheres;Modeling;Modulus;mouse model;Mus;Music;neuroprosthesis;new technology;novel;novel therapeutics;Patients;Performance;Platinum;polycaprolactone;polymerization;Polymers;pre-clinical;preservation;prevent;Process;Property;Proteins;radiological imaging;Reaction;Reporter;Residual state;Resistance;Resolution;response;Safety;sheep model;Signal Transduction;Silastic;speech in noise;Staphylococcus aureus;Structure;Surface;surface coating;Surface Properties;System;Technology;Testing;Thick;Thinness;Tissues;Transducers;Translations;Trauma;Water;Work;X ray microscopy

PROJECT_TITLE: Reduction of Intracochlear Trauma and Fibrosis Using Dual Network, Zwitterionic Hydrogel Thin Films on Cochlear Implant Surfaces

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Comparative Effectiveness Research;Kidney Disease;Pediatric

PI_NAMEs: ZEE, JARCY  (contact)

PROJECT_TERMS: acute care;acute infection;Adrenal Cortex Hormones;Blood Pressure;Calcium;Characteristics;Child;Child Care;Childhood;Chronic Kidney Failure;Clinical;clinical care;Clinical effectiveness;clinical practice;Clinical Trials;Cohort Studies;Comparative Effectiveness Research;Computer software;Data;data resource;Databases;Disease;Disease remission;Documentation;Dose;Electronic Health Record;Enrollment;Event;evidence base;experience;Fracture;frailty;Goals;health care service utilization;Health system;Hospitalization;improved;Infection;inhibitor;inorganic phosphate;Interdisciplinary Study;interest;Intervention;Kidney Diseases;Knowledge;Learning;Literature;longitudinal analysis;Methodology;Methods;Modeling;Monte Carlo Method;Morbidity - disease rate;Nephrology;novel;observational cohort study;Observational Study;Outcome;Outcomes Research;participant enrollment;Patients;Performance;Population;Population Heterogeneity;pragmatic trial;Property;Proteinuria;Protocols documentation;PTH gene;Recurrence;Relapse;Renal function;Renal glomerular disease;Renin-Angiotensin-Aldosterone System;Risk;Sampling;Serum;Serum Albumin;simulation;skeletal;Statistical Methods;Structural Models;Testing;Theoretical model;Time;tool;treatment effect;Treatment Effectiveness;trial design;user-friendly

PROJECT_TITLE: Causal effects of time-varying treatments on recurrent event outcomes


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emergency Care;Health Services;Hematology;Infectious Diseases;Kidney Disease;Pediatric;Prevention;Sepsis

PI_NAMEs: FITZGERALD, JULIE C. HOLLOWS (contact);FURTH, SUSAN L.

PROJECT_TERMS: Accident and Emergency department;Acute;Acute Renal Failure with Renal Papillary Necrosis;Adult;adverse outcome;Affect;Ancillary Study;arm;Biological;Cessation of life;Child;Childhood;Chronic Kidney Failure;Clinical;Clinical Trials;Code;cohort;comparative effectiveness;Comparative Effectiveness Research;cost effective;Creatinine;Critically ill children;crystalloid;Data;data acquisition;Databases;design;Development;Diagnosis;disability;Electronic Health Record;Enrollment;Event;Exhibits;Fluid Balance;follow-up;Functional disorder;Funding;Glomerular Filtration Rate;Goals;Health Information System;Health system;Hospitalization;Hypertension;Infection;Injury to Kidney;innovation;Kidney;Kidney Diseases;kidney dysfunction;Knowledge;Learning;Life;Link;Liquid substance;Measures;Mediating;Medical emergency;Mission;Modeling;multidisciplinary;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;nephrogenesis;Nephrology;Normal saline;Observational Study;Organ;Outcome;Participant;Patients;pediatric sepsis;Population;prevent;Probability;prospective;Proteinuria;Quasi-experiment;Randomized;randomized, clinical trials;Registries;Renal function;Renal Replacement Therapy;Research;Research Design;Resuscitation;Risk;Risk Factors;Sepsis;Septic Shock;Serum;Severities;Site;sociodemographics;Source;Survivors;Testing;Translating;Work

PROJECT_TITLE: Comparative effectiveness of balanced fluids versus normal saline to reduce acute and chronic kidney disease in children with sepsis


ORG_NAME: WISTAR INSTITUTE

PHR: Project Narrative – Overall Despite major advances, the death rate from skin cancer remains unacceptably high. In this proposal 3 Projects address the challenges of immunotherapy in melanoma by identifying predictors of response to therapy, novel combinations of drugs designed to enhance response, new approaches to the timing of therapy administration, and the examination of novel tumor microenvironments and their effect on therapy response. This SPORE’s 3 Cores and Developmental Programs are designed to bring together clinical investigators and basic scientists in highly translational efforts to accelerate the pace of therapy for patients suffering from melanoma and other skin cancers, including cutaneous squamous cell carcinoma (cSCC), cutaneous T cell lymphoma (CTCL), or Merkel cell carcinoma.

PI_NAMEs: AMARAVADI, RAVI K;HERLYN, MEENHARD F (contact)

PROGRAM_OFFICER_NAME: KUZMIN, IGOR A

PROJECT_TERMS: Acceleration;Address;Adjuvant;anti-PD1 antibodies;anti-PD1 therapy;Antibody Therapy;Autophagocytosis;base;bench to bedside;Biological;Biological Assay;Biological Markers;Blood;BRAF gene;Cancer Patient;career;CD8-Positive T-Lymphocytes;cell killing;checkpoint inhibition;Clinical;Clinical Investigator;Clinical Management;Clinical Trials;cohort;Collaborations;Combination immunotherapy;Cutaneous T-cell lymphoma;Data;Death Rate;Dendritic Cells;design;Development;Disease;Disease Progression;Disease regression;disorder risk;Dose;Drug Design;Early treatment;effective therapy;exosome;experience;Funding;Genetic;Genomics;high risk;Immune;Immune checkpoint inhibitor;Immune response;Immunologics;Immunotherapeutic agent;Immunotherapy;Impairment;improved;In complete remission;industry partner;inhibition of autophagy;inhibitor;innovation;insight;Institution;Intervention Trial;ipilimumab;Knowledge;Leadership;Life;Lymphoma cell;Macrophage;Malignant Neoplasms;Measurement;Medicine;Melanoma;Melanoma patient;Mentors;Merkel cell carcinoma;Mission;Molecular Target;mutant;Nature;Neoadjuvant Therapy;neoplastic cell;Nivolumab;novel;novel drug combination;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Pathologic;Pathway interactions;Patient Selection;Patients;pembrolizumab;Peripheral;pre-clinical;preclinical study;predicting response;Prediction of Response to Therapy;predictive marker;programmed cell death ligand 1;programs;Recording of previous events;Refractory;Regimen;Reporting;Research;Research Design;Research Personnel;Resources;response;response biomarker;Scientist;Sensitivity and Specificity;Series;side effect;Skin;Skin Cancer;Skin Carcinoma;skin squamous cell carcinoma;T-Lymphocyte;targeted treatment;The Wistar Institute;Therapeutic;Toxic effect;Translating;treatment response;Treatment-related toxicity;Tumor Bank;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumorigenic;Work

PROJECT_TITLE: SPORE in Skin Cancer


NIH_SPENDING_CATS: Cancer;Skin Cancer

PHR: Project Narrative – Core A The overall goal of the Administrative Core is to provide the administrative structure for the efficient and fair review and allocation of resources, scientific and regulatory oversight, and to act as a conduit for the rapid execution of SPORE goals. Core A will facilitate the sharing of resources, the communication between the investigators, and provide oversight for the awarding of career enhancement and pilot awards. This Core includes a clinical trials advisory committee, specifically designed to accelerate the pace of translational research, a key objective of this SPORE proposal.

PI_NAMEs: HERLYN, MEENHARD F (contact)

PROJECT_TERMS: Acceleration;Advisory Committees;Advocate;Award;Cancer Center;career;Cementation;Clinical Trials;Collaborations;Collection;Communication;conflict resolution;Country;data sharing;design;Development;Ensure;Environment;experience;Faculty;Fostering;Funding;Goals;Grant;Guidelines;human subject;IACUC;Infrastructure;Institution;Institutional Review Boards;Leadership;lectures;meetings;Melanoma;member;organizational structure;Patient Care;Patients;Pilot Projects;Policies;programs;Progress Reports;Recording of previous events;Regulation;Research;Research Personnel;Resource Allocation;Resource Sharing;Retirement;Role;Running;Series;Services;Site;Skin Cancer;Structure;symposium;Talents;Technology;The Wistar Institute;Translational Research;Vertebrates;webinar;Work


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Precision Medicine

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

PHR: Project Narrative The proposed research is relevant to public health because it aims to design and develop a soft, wearable electronic platform that enables real-time, quantitative, simultaneous, and continuous measurements of a panel of molecular biomarkers for immune monitoring over long durations.

PI_NAMEs: TIAN, LIMEI  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: accurate diagnosis;Address;Biochemical;bioelectronics;Biological;Biological Assay;Biosensing Techniques;Biosensor;Body Fluids;Chemicals;Clinical;Complex;Consumption;cytokine;design;Detection;Devices;Diagnosis;Disease;Encapsulated;Enzyme-Linked Immunosorbent Assay;Equipment;flexibility;Fluorescence;Goals;Health;Human body;Human Resources;Immune;Immunologic Monitoring;Immunological Diagnosis;Immunosorbents;Implant;in vivo monitoring;insight;Intervention;Link;Measurement;Medical;Methods;Molecular;molecular marker;molecular phenotype;Monitor;novel;Outcome;personalized medicine;Process;Prognosis;programs;protein biomarkers;protein profiling;Proteins;Public Health;Reagent;Research;Specificity;systemic inflammatory response;Technology;temporal measurement;therapeutically effective;Time;tool;Training;Transistors;wearable device;Western Blotting

PROJECT_TITLE: Continuous metabolite and protein profiling for immune monitoring

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


NIH_SPENDING_CATS: Aging;Cancer;Childhood Leukemia;Clinical Research;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE With no cure for older patients afflicted with Acute Myeloid Leukemia (AML), this proposal investigates how the loss of a newly identified protein that controls mitochondrial activity will impact the disease. AML depends on the metabolic pathways in mitochondria and our hypothesis is that targeting this single regulator can simultaneously cripple multiple hallmarks of the cancer. Establishing the extent of its control is the critical first step towards being able to target this new protein as a vulnerability for AML.

PI_NAMEs: CAMBRONNE, XIAOLU ANG (contact)

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;addiction;Adjuvant;Affect;age group;aging population;Apoptosis;Area;Binding;Binding Sites;Biosensor;Bone Marrow Transplantation;c-myc Genes;Carbon;Cell Line;Cells;chemotherapy;chemotherapy induced neuropathy;ChIP-seq;Citric Acid Cycle;Clinical;combinatorial;Complex;Consumption;Cytoplasm;Data;Data Set;Deoxyribonucleases;Dependence;deprivation;Disease;disease model;Environment;fitness;Genetic;Glutaminase;Glutamine;Hematopoietic stem cells;Human;human old age (65+);Hypersensitivity;Immunotherapy;in vivo;Individual;inhibitor;Malate-Aspartate Shuttle Pathway;Malignant Neoplasms;Mammalian Cell;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Mitochondrial Matrix;mitochondrial metabolism;Mitochondrial Proteins;Modeling;Molecular;mortality;mouse model;Mutate;Myelosuppression;Nature;Nicotinamide adenine dinucleotide;older patient;Oxidative Phosphorylation;Pathway interactions;Patients;Phenotype;Production;Proliferating;promoter;Proteins;Publishing;Recurrent disease;Refractory;Regulation;Relapse;Research;Resistance development;Role;Sampling;Source;Specimen;Supplementation;Survival Rate;Testing;Therapeutic;therapeutic target;Time;Toxic effect;trait;Tumor Burden;tumor metabolism;Tumor Promotion;tumorigenesis;Work;Xenograft procedure

PROJECT_TITLE: Mitochondrial NAD+ in Acute Myeloid Leukemias

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ORG_CITY: PITTSBURGH

ORG_DEPT: CHEMISTRY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative: The studies described in this research proposal will lead to a broader understanding of the copper biochemistry associated with the oxidation of organic molecules (e.g. hydroxylation of methane). We are particularly interested in understanding the structure, spectroscopy and reactivity of the Cu/O2 species formed in Cu- dependent monooxygenase enzymes. The use of synthetic inorganic complexes that mimic some features of the active centers of these enzymes will allow us to generate metastable LCu/O2 species and evaluate their reactivity towards biologically relevant C-H hydroxylation reactions.

PI_NAMEs: GARCIA-BOSCH, ISAAC  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Functional Synthetic Models of Cu-dependent Monooxygenases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


PHR: Project Narrative – Biospecimen and Pathology Core B This long standing Core has made significant contributions to skin cancer research, providing annotated tumor samples, as well as specialized expertise in mouse models. These samples and the DNA, RNA, proteins, and cells derived from tumors are the foundation of any translational program. This Core collects IRB-consented patient samples and clinical data, distributes the tissues to SPORE researchers, and analyzes tissues using cutting edge technology and innovative and rigorous approaches.

PI_NAMEs: XU, XIAOWEI  (contact)

PROJECT_TERMS: anti-cancer research;Benign;Biological Assay;Biological Markers;Biological Specimen Banks;Biological Specimen database;Blood;Cancer Center;career;Cell Line;Cells;Clinical;Clinical Data;clinical database;Clinical Trials;Collaborations;Confidentiality of Patient Information;Consent;cost effectiveness;Data;Databases;Dendritic Cells;Development;DNA;Ensure;Evaluation;experience;follow-up;Foundations;Funding;Guidelines;Histologic;Histology;Human;humanized mouse;Immunohistochemistry;Immunologics;Immunotherapy;Informatics;Information Technology;Infrastructure;innovation;Institution;Institutional Review Boards;Malignant - descriptor;Malignant Neoplasms;Melanoma;Melanoma Cell;Methodology;Methods;Molecular;mouse model;Mus;Neoplasm Metastasis;Normal tissue morphology;novel therapeutics;Paraffin Embedding;Pathologic;Pathologist;Pathology;patient derived xenograft model;Patients;Peripheral Blood Mononuclear Cell;Plasma;Primary Neoplasm;Procedures;Process;Program Research Project Grants;programs;Proteins;Protocols documentation;Publications;Recording of previous events;Recurrence;Research;Research Personnel;Residual state;Resource Allocation;Resources;RNA;Sampling;Services;Shapes;Signal Transduction;Site;Skin Cancer;Solid;Specific qualifier value;Specimen;Standardization;Surgeon;System;Technology;Testing;therapy development;therapy resistant;Time;Tissue Embedding;tissue preparation;tissue processing;tissue resource;Tissues;translational cancer research;Translational Research;translational scientist;tumor;Tumor Tissue;Tumor-associated macrophages;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Biospecimen and Pathology Core