NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Mental Illness;Rehabilitation;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative This project is designed to determine if a computer-delivered cognitive-behavioral treatment can improve the otherwise poor alcohol use disorder treatment outcomes for individuals with a co- occurring anxiety disorder. In the past, we showed that this treatment does improve outcomes for these individuals when delivered by a therapist. If the present work shows that the computer- delivered version is also effective, it would provide an inexpensive program with virtually unlimited scalability to enable access to the treatment by many more individuals than is currently the case.

PI_NAMEs: KUSHNER, MATT G (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: active control;Address;Adoption;Aftercare;alcohol comorbidity;Alcohol consumption;alcohol use disorder;Alcohols;Anxiety;Anxiety Disorders;anxiety reduction;anxiety symptoms;anxiety treatment;Attenuated;Behavioral;Belief;Clinical;clinical efficacy;Cognitive;Cognitive Therapy;Communities;comorbidity;comparison control;computer program;Computers;Control Groups;coping;Coping Skills;Data;design;drinking;drinking behavior;Ecological momentary assessment;Education;Educational process of instructing;Environment;Expectancy;experience;Exposure to;Feedback;follow up assessment;follow-up;Funding;Goals;Health Services Accessibility;healthy lifestyle;Heavy Drinking;Hour;improved;improved outcome;Individual;interactive feedback;internet delivery;Intervention;Knowledge;Knowledge acquisition;Learning;Mediating;Meta-Analysis;Modeling;negative affect;Neurosciences;Outcome;pandemic disease;Participant;Patients;Pattern;Physiological Processes;Process;programs;Psychiatric therapeutic procedure;Psychotherapy;Randomized;Randomized, Controlled Trials;reduce symptoms;Relapse;remote intervention;Research;research to practice;Resources;Risk;Series;skill acquisition;skills;Subgroup;System;Technical Expertise;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;Time;Training;transmission process;treatment as usual;treatment center;Treatment outcome;treatment program;trial comparing;virtual;Work

PROJECT_TITLE: Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Persons who inject drugs (PWID) represent a key `superspreader' population for HIV/AIDS that drives the epidemic in the US and other countries and it is exceptionally difficult to identify and reach these high-risk populations with existing intervention strategies (e.g., ART and PrEP). This proposal will develop and test a novel gene-drive concept to target the high-risk superspreaders who most need therapy. Gene drives would be particularly useful for treating PWID and those who engage in injection drug use in resource-limited settings, including the rural US.

PI_NAMEs: WEINBERGER, LEOR S (contact)

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Animals;Biological Assay;Brazil;Burkina Faso;Cells;Clinical;Clinical Trials;cohort;Communicable Diseases;Complement;cost;Country;County;Data;Development;Disease;Disease Outbreaks;disorder control;Drug usage;end of life;Engineering;Epidemic;Epidemiologist;Epidemiology;Failure;female sex worker;gene drive system;gene therapy;Genes;genotoxicity;Gifts;high risk;high risk behavior;high risk population;HIV;HIV Infections;HIV therapy;HIV/AIDS;humanized mouse;immunogenicity;In Vitro;Incidence;Indiana;Injecting drug user;injection drug use;Intervention;Intervention Trial;Location;Malaria;Measures;Modeling;Modernization;Nature;nonhuman primate;novel;pathogen;Patients;Phase;Population;pre-exposure prophylaxis;prototype;Reporting;Resistance;Resource-limited setting;Risk Factors;RNA Interference;Rural;Safety;safety testing;synthetic construct;Testing;transmission process;United States National Academy of Sciences;Update;Variant;Viremia

PROJECT_TITLE: A Gene Drive Therapy for HIV: single-administration intervention for high-risk groups


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Non-Hispanic Black women have higher rates of preterm birth (< 37 completed weeks gestation) compared with non-Hispanic White women. Preterm birth is the leading cause of infant mortality among Black infants. We will examine biological aging as a marker of social factors (e.g., experiences of racial discrimination) and biomarker indicating risk of preterm birth among Black women.

PI_NAMEs: GIURGESCU, CARMEN  (contact);OHM, JOYCE ELLEN

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: 37 weeks gestation;accelerated epigenetic aging;Acceleration;Address;Age;age acceleration;age related;Age Years;Aging;Area;Biological;Biological Aging;Biological Markers;Birth;bisulfite sequencing;black men;Black Populations;Black race;black women;Blood;Blood specimen;case control;Cell Aging;Chronic stress;Chronology;cohort;Coupled;COVID-19 pandemic;Crime;Data;design;Disease;DNA;DNA Methylation;driving force;Enrollment;Epigenetic age;epigenetic aging;epigenetic clock;experience;Genetic;Gestational Age;Goals;high risk;Individual;Individual Differences;Infant;Infant Mortality;inter-individual variation;Length;Life Experience;Maternal Age;Measures;Medical Records;Methylation;metropolitan;neighborhood disadvantage;Neighborhoods;Not Hispanic or Latino;novel;Participant;Pattern;Performance;Precision Health;Pregnancy;Pregnant Women;Premature Birth;prevent;Prevention;Publishing;Questionnaires;Race;racial discrimination;racism;Reporting;Research;Ribosomal DNA;Ribosomes;Risk;Risk Assessment;Risk Factors;Saliva;Sampling;Shapes;social factors;social stressor;systematic review;telomere;Term Birth;therapeutic target;White Women;Whole Blood;Woman;Work

PROJECT_TITLE: Epigenetic aging, social factors, and preterm birth among Black women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(90)S]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_STATE: MN

PI_NAMEs: MCGUE, MATTHEW K. (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: Achievement;Acute;Address;Adolescence;Adolescent;Adult;Age;Alcohol consumption;Alcohol dependence;alcohol poisoning;Alcoholic beverage heavy drinker;Alcohols;Antisocial Personality Disorder;automobile accident;Behavior;behavioral disinhibition;binge drinking;Characteristics;cognitive function;cohort;comorbidity;course development;Data;Data Analyses;Deposition;design;Development;Disease;drinking;early drinking;Education;emerging adult;Environmental Risk Factor;Evaluation;experimental study;Family Study;follow-up;Gender;gender difference;Genetic;Habits;Heavy Drinking;high-risk adolescents;Individual;innovation;Instruction;Investigation;late life;Left;Length;Life;Life Stress;Link;Literature;Long-Term Effects;longitudinal design;Longitudinal Studies;Medical;member;men;Mental Depression;Mental Health;Methods;middle age;Minnesota;Modeling;Neurocognitive;Occupational;Outcome;Patient Self-Report;Pattern;Persons;physical conditioning;Predisposition;prospective;Prospective Studies;Prospective, cohort study;psychosocial;psychosocial outcome;public repository;Research;Research Design;Research Personnel;Risk;Risk Factors;Role;sexual victimization;social;Social Functioning;Social isolation;Spouses;Substance abuse problem;substance use;Surveys;telomere;Testing;Twin Multiple Birth;Twin Studies;underage drinking;Woman;Youth

PROJECT_TITLE: Adolescent drinking and midlife outcomes: A prospective cotwin control study

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Heart Disease

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE This project seeks to determine the effects of diminished pulsatility during continuous flow ventricular assist device (CF-VAD) support on human aortic endothelial cells (HAECs). Changes in production of pro- angiogenic/pro-inflammatory cytokines will be used as biomarkers to evaluate the effects of loss of pulsatility and help validate new approaches to introduce artificial pulsatility in CF-VADs.

PI_NAMEs: SETHU, PALANIAPPAN  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Activities of Daily Living;Address;Adverse event;Affect;Age Years;Animal Model;Animals;Antioxidants;Aorta;Arteriovenous malformation;Biological Markers;Blood specimen;Blood Vessels;Brain hemorrhage;cardiac aging;Cardiovascular system;Categories;Cell Line;Cell Separation;Cells;cytokine;Data;deep learning;Development;Devices;Endothelial Cells;endothelial dysfunction;Endothelin-1;Endothelium;energy efficiency;Event;experience;Frequencies;Functional disorder;Gastrointestinal Hemorrhage;Heart failure;hemodynamics;Hemorrhage;Human;improved;In Vitro;Individual;Inflammatory;Machine Learning;Mediating;Medical;Modeling;Monitor;novel strategies;operation;Operative Surgical Procedures;Organ;patient response;Patient Selection;Patients;Perfusion;Physiologic pulse;Physiological;preservation;pressure;prevent;Production;Protocols documentation;Publishing;Pulsatile Flow;Pulse Pressure;Pump;Quality of life;Quantitative Evaluations;Refractory;Regulation;response;Risk Factors;safety testing;Sampling;Serum;Sheep;Side;Signal Transduction;Speed;Techniques;Testing;Time;Tissue Sample;Transducers;Translating;Validation;ventricular assist device;VWF gene;Work

PROJECT_TITLE: Selection of Flow Modulation Protocols for Patients on Continuous Flow Ventricular Assist Devices (CF-VADs)

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: HELENA

ORG_NAME: MONTANA STATE DEPT/PUB HLTH & HUMAN SRVS

ORG_STATE: MT

PHR: Application for Funding Opportunity RFA-DP-21-001 Montana Pregnancy Risk Assessment Monitoring System (MT PRAMS) Component A: Core Surveillance PROJECT NARRATIVE The Montana Pregnancy Risk Assessment Monitoring System (MT PRAMS) collects Montana- specific data on selected maternal behaviors and experiences that occur prior to, during, and shortly after pregnancy. MT PRAMS survey methods provide necessary data for Montana to monitor emerging issues that may arise during the data collection cycle including the response to post-disaster or pandemic surveillance needs.

PI_NAMEs: DOBRINEN, ERIN  (contact)


ORG_CITY: PHOENIX

ORG_NAME: ARIZONA STATE DEPARTMENT OF HLTH SRVCS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The Arizona Pregnancy Risk Assessment and Monitoring System (Arizona PRAMS) provides data on pregnancy experience and health status of new mothers and infants. Risk factors for adverse pregnancy and birth outcomes are compared across population subgroups and allow the Arizona Department of Health Services to more effectively tailor preconception, pregnancy, and postpartum services and programs to Arizona’s diverse population.

PI_NAMEs: CELAYA, MARTIN F (contact)

PROJECT_TITLE: PRAMS DP21-001


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Improper storage of glucose and fatty acids after eating a meal has been implicated in the negative consequences of obesity. This application will investigate the adenosine receptors in fat during postprandial metabolism and adenosine receptor function becomes defective in obesity.

PI_NAMEs: HARRIS, THURL E. (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Adenosine;Adenosine A1 Receptor;Adenosine A2B Receptor;Adipocytes;Adipose tissue;ADORA1 gene;ADORA2B gene;antagonist;Autocrine Communication;Awareness;Biofeedback;Blood;blood glucose regulation;Catecholamines;Characteristics;Chronic;Coupled;Data;Defect;diabetic patient;Eating;energy balance;Equilibrium;Fasting;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;Feedback;feeding;FOXO1A gene;functional outcomes;Genetic;Glucose;glucose production;Hepatic;Homeostasis;hormonal signals;Hour;Human;Hyperglycemia;Impairment;improved;Insulin;insulin regulation;Insulin Resistance;insulin sensitivity;Intervention;Investigation;Lipids;Lipolysis;lipolysis-stimulated receptor;Metabolic;Metabolism;Mus;NF-kappa B;Nonesterified Fatty Acids;novel;Obese Mice;obese patients;Obesity;Overnutrition;Paracrine Communication;Pathogenicity;Pathologic;Patients;Peripheral;pharmacologic;Pharmacologic Substance;Physiological;Postprandial Period;Prediabetes syndrome;Purinergic P1 Receptors;receptor;Receptor Activation;receptor expression;receptor function;Receptor Signaling;response;Role;Secondary to;Signal Transduction;Signaling Molecule;System;Testing;Tissues;TLR4 gene;Triglycerides

PROJECT_TITLE: Adenosine receptors and metacolic homeostasis

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Acute Respiratory Distress Syndrome;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Infectious Diseases;Lung;Neurodegenerative;Neurosciences;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: MOBILE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

PHR: PROJECT NARRATIVE Pneumonia causes high rates of patient morbidity and mortality, through poorly understood mechanisms. We recently discovered a novel infection-dependent mechanism of lung injury and end organ dysfunction, where pathogens interact with the endothelium to elicit production of cytotoxic tau variants. Here, we examine mechanisms of pneumonia-elicited endothelial cytotoxic tau production and assess the role of cytotoxic tau in end organ dysfunction.

PI_NAMEs: STEVENS, TROY  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute Lung Injury;Address;Adenylate Cyclase;Alveolar;Bacteria;Bacterial Infections;Bacterial Pneumonia;Binding;Bioenergetics;Blood;Blood capillaries;Blood Vessels;brain parenchyma;Bronchoalveolar Lavage Fluid;Capillary Permeability;Cells;Cerebrospinal Fluid;Clinical;Communication;Consumption;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Cyclic Nucleotides;cytotoxic;Data;Dedications;Dissociation;Edema;Endothelial Cells;endothelial repair;Endothelium;Enzymes;exoenzyme;Functional disorder;Gases;Generations;Homologous Gene;Hydrolase;Impairment;Infection;innate immune mechanisms;Interleukin-1 Receptors;Knowledge;Lung;lung injury;lung repair;Mammalian Cell;Membrane;metabolomics;microorganism;Microtubules;Morbidity - disease rate;mortality;mutant;Niacinamide;Nicotinamide adenine dinucleotide;novel;Organ;pathogen;Patients;Peripheral;Permeability;Phosphorylation;Pneumonia;prevent;Process;Production;Protein Kinase;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Recovery;repaired;response;Role;Signal Transduction;Site;Sterility;Stimulus;Structure;tau Proteins;tau-1;Tauopathies;Tertiary Protein Structure;Testing;Type III Secretion System Pathway;Variant;Work

PROJECT_TITLE: Soluble adenylyl cyclases in lung endothelial tauopathy

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: CA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Therapeutics such as Taxol are indicated for the treatment of patients with breast, ovarian and lung malignancies; however, resistance frequently emerges and/or patients develop toxicities that limit the duration of treatment. We have engineered novel Taxol-like molecules that cause both apoptosis and durable senescence in therapeutically recalcitrant tumors and will use chemical, molecular and biological methods to optimization these molecules for therapeutic efficacy and tolerability. The long-term goal is to generate best-in- class Taxol-like molecules rigorously evaluated to meet pre-clinical efficacy and toxicity benchmarks.

PI_NAMEs: MCDAID, HAYLEY M. (contact);SMITH, AMOS B

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Address;Alkenes;analog;anti-cancer;Apoptosis;Back;Behavioral;Benchmarking;Biochemical;Biochemistry;Biological;Breast;Breast Cancer Model;C57BL/6 Mouse;cancer cell;Cancer cell line;cancer therapy;carcinogenesis;Cell Aging;Cell Death;Cell Death Induction;cell injury;cell killing;Cell model;Cells;chemical synthesis;Chemicals;Chemistry;Clinical;Complex;Cryoelectron Microscopy;Cytotoxic agent;Cytotoxic Chemotherapy;design;Development;discodermolide;Dose;drug development;Engineering;Evaluation;fluorescence imaging;Funding;Goals;Hematology;Human;Image;immunogenic;improved;In Vitro;in vivo;in vivo evaluation;Induction of Apoptosis;insight;interest;Lactones;Lead;Ligands;live cell imaging;Longevity;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Metabolic;Methods;Microtubule Stabilization;Microtubules;Modeling;Molecular;mouse model;multidisciplinary;Natural Products;Neuropathy;novel;Occupations;Ovarian;Paclitaxel;Parents;Patient-derived xenograft models of breast cancer;Patients;pharmacologic;Pharmacology;pharmacophore;Phase;Phenotype;pre-clinical;preclinical development;preclinical efficacy;preclinical study;preclinical toxicity;prevent;programs;Proliferating;Property;rational design;Recombinants;Refractory;refractory cancer;Resistance;response;Role;Safety;scaffold;screening;senescence;senolytics;Site;Small Business Innovation Research Grant;structural biology;taxane;Therapeutic;tool;Toxic effect;treatment duration;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;Tubulin;tumor;uptake;X-Ray Crystallography

PROJECT_TITLE: Novel taxane-site tubulin ligands with a dual apoptosis and senescence-inducing mechanism of action

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DMPC-J (90)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Viral pneumonia, often due to infection with influenza A virus and SARS-CoV-2, represents the leading infectious cause of death worldwide. Regulatory T (Treg) cells coordinate recovery from viral pneumonia, but a subset of Tregs known as induced Tregs (iTregs) have the potential to become unstable and lose their suppressive and reparative functions. We aim to identify mechanisms through which iTregs become unstable and target these mechanisms to promote their utility in hastening recovery from viral pneumonia.

PI_NAMEs: JOUDI, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Adaptor Signaling Protein;Adoptive Cell Transfers;Adoptive Transfer;bisulfite sequencing;Blood Component Removal;career;Cause of Death;CD4 Positive T Lymphocytes;Cell Physiology;Cell Therapy;cell type;Cells;Clinical;Credentialing;Data;DNA Methylation;DNA methylation profiling;DNA Modification Methylases;effector T cell;Environment;Epigenetic Process;experience;Experimental Designs;Failure;Fellowship;Flow Cytometry;Foundations;FOXP3 gene;Gene Expression Profiling;Generations;Genetic Transcription;genomic locus;Goals;Homeostasis;Immune;Immune system;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;Influenza;Influenza A virus;Injury;insight;Intensive Care Units;Knowledge;Laboratories;lung injury;lung repair;Maintenance;Mediating;Mentors;Mentorship;Methods;methylation pattern;Morbidity - disease rate;mortality;Mus;National Research Service Awards;Patient-Focused Outcomes;Patients;Pattern;Phenotype;Physicians;Positioning Attribute;Process;programs;Publishing;Pulmonary Inflammation;Reagent;Recovery;Recovery of Function;Regulatory T-Lymphocyte;repair function;repaired;Reporting;Research;Resolution;Resources;respiratory virus;Risk;Role;Scientist;Severities;skills;Structure of parenchyma of lung;Supportive care;System;T-Lymphocyte;Tamoxifen;Technical Expertise;Techniques;Testing;Therapeutic;Thymus Gland;Time;tissue repair;Training;transcription factor;transcriptome sequencing;Transforming Growth Factor beta;Umbilical Cord Blood;Validation;Viral;Viral Pneumonia;Work

PROJECT_TITLE: The role of epigenetic regulator UHRF1 in stability of induced regulatory T-cell function during influenza A virus-induced lung injury


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Malaria and other vector-borne diseases impose devastating impacts on global health and human welfare, and new tools are now urgently needed to combat these rebounding scourges. We have been leaders in developing gene-drive or "active genetic" technologies to disseminate favorable traits throughout populations such as factors blocking transmission of malarial parasites by Anopheline mosquitoes. We propose to advance these game-changing tools to develop next-generation drive systems and corresponding neutralization elements required to move this promising technology forward to practical implementation.

PI_NAMEs: BIER, ETHAN  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Acceleration;Alleles;Anopheles Genus;Anti-malarials;Antibiotic Resistance;Antibodies;Bacteria;Binding;Blastoderm;blocking factor;Child;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;combat;Combination Drug Therapy;Complementary DNA;Complex;cost;CRISPR gene drive;Culicidae;design;Development;Disease;DNA;DNA cassette;DNA Double Strand Break;DNA Repair;Drosophila genus;Drug resistance;Elements;Embryo;embryo cell;endonuclease;Event;experimental study;Female;flexibility;fly;food insecurity;Foundations;functional restoration;Future;gene drive system;Genes;Genetic;genetic element;genetic technology;genetic variant;Genome;genomic locus;Genomics;Germ Cells;Germ Lines;global health;Government;Grant;Guide RNA;Health;Heterozygote;Homologous Gene;Human;Image;imaging modality;Immunize;Individual;Inherited;Insect Vectors;Insecta;Insecticide Resistance;Insecticides;Intervention;Laboratories;loss of function;Malaria;malaria transmission;Mammals;Measures;Mediating;Methods;Mosaicism;Mus;Mutagenesis;mutagenic chain reaction;Mutate;next generation;novel;Parasite resistance;Parasites;pathogen;Pathway interactions;Performance;Persons;Phlebotominae;Population;Poverty;Poverty Areas;pragmatic implementation;Prevalence;Process;Prokaryotic Cells;prototype;rational design;Reaction;repaired;Reproduction;Resistance;Sanitation;Scourge;Site;Source;Specific qualifier value;Sterility;System;Target Populations;Technology;Testing;tool;trait;Transgenes;transmission process;Tsetse Flies;Update;vector;Vector-transmitted infectious disease;Virus;Visualization;welfare;World Health Organization

PROJECT_TITLE: The mutagenic chain reaction: a method for autocatalyic gene dissemination

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Although the prevalence and incidence of dementia appears to be stable or declining in high-income countries, South American countries (SAC) face the opposite scenario, with increased dementia prevalence, probably triggered by a combination of genetic and socioeconomic status (SES) factors. This proposal aims to create the first SAC-based multicenter initiative to study dementia, by combining genomic, neuroimaging, and behavioral (cognitive, clinical, socioeconomic) data. This project constitutes an unprecedented opportunity to foster regional synergy and multilevel research towards the harmonization of global strategies to fight dementia in SAC.

PI_NAMEs: AGUILLON, DAVID FERNANDO;CUSTODIO, NILTON ;IBANEZ, AGUSTIN M.;MILLER, BRUCE L (contact);POSSIN, KATHERINE LAUREL;TAKADA, LEONEL TADAO;YOKOYAMA, JENNIFER S

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Accounting;Address;Affect;African;Age;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Argentina;Automobile Driving;autosome;Behavioral;Brain imaging;Brazil;Cerebrum;Clinical;Clinical assessments;Cognition;Cognitive;cognitive performance;cognitive testing;cohort;Colombia;Country;Cross-Sectional Studies;Data;Data Set;demented;Dementia;dementia risk;Development;Discrimination;Disease;disorder prevention;Disparity;Education;epidemiology study;European;Evaluation;experience;Face;Family;fighting;Fostering;Frequencies;Frontotemporal Dementia;Future;gene environment interaction;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic Variation;genome wide association study;Genomics;Geography;Goals;Heterogeneity;Human;Image;Incidence;Income;Indigenous;innovation;International;learning strategy;lipid metabolism;Longitudinal Studies;low socioeconomic status;Machine Learning;Measures;Mediating;Methodology;multimodal learning;multimodal neuroimaging;multimodality;Mutation;Nerve Degeneration;neural;Neurocognitive;Neurodegenerative Disorders;neuroimaging;novel;Outcome;Outcome Study;Participant;Pathway interactions;Patients;Persons;Peru;polygenic risk score;Population;Population Heterogeneity;Positioning Attribute;Prevalence;Probability;Protocols documentation;rare variant;recruit;Research;Risk;Risk Factors;Risk Reduction;Role;Sample Size;Sampling;Severity of illness;social health determinants;Socioeconomic Factors;Socioeconomic Status;socioeconomics;South American;Standardization;synergism;Techniques;Testing;trait;Translational Research;Underrepresented Populations;Work

PROJECT_TITLE: US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative Research


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Veterans are at higher risk for chronic respiratory diseases (CRDs), including chronic obstructive pulmonary disease (COPD) and interstitial lung disease, relative to the general population due to deployment-related and occupational exposures and increased rates of smoking. Although early diagnosis and treatment can improve outcomes, no screening programs for the early detection of CRDs currently exist – as a result, many CRDs are detected late, often when symptoms are severe. Unlike for CRDs, screening programs for lung cancer using low-dose chest computed tomography (CT) scans do exist and changes in the lungs due to CRDs can be detected on these studies. This project will use specialized computer software to analyze chest CT scans obtained for lung cancer screening to detect changes in the lungs due to CRDs. These computer measurements will be used to develop a tool to help identify undiagnosed CRD among Veterans so that they may receive timely, personalized care.

PI_NAMEs: WAN, EMILY S (contact)

PROJECT_TERMS: Accident and Emergency department;Acute;Archives;Blood Tests;Boston;Caring;Cause of Death;chest computed tomography;Chest imaging;Chronic;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;cigarette smoking;Clinical;Computer software;Computers;Data;data integration;Development;Diagnosis;Diffusion;disability;Disease;Disease Management;Disease Progression;Dose;Early Diagnosis;Early treatment;Elderly;Emergency Situation;Event;exercise capacity;Exhibits;firewall;Functional impairment;functional status;Future;General Population;health care service utilization;health related quality of life;High Prevalence;high risk;high risk population;Hospitalization;Image;Image Analysis;image archival system;imaging modality;imaging platform;imaging study;Impairment;improved outcome;Incidence;Individual;inflammatory marker;innovation;inter-individual variation;interstitial;Interstitial Lung Diseases;Literature;Lung;lung cancer screening;Lung Diseases;Lung nodule;Malignant neoplasm of lung;Measurement;Medical;Medical Imaging;Medical Records;Methods;military veteran;Modeling;mortality;Nature;Occupational Exposure;open source;Outcome;Outpatients;participant enrollment;Pathologic;personalized care;Persons;Pharmaceutical Preparations;Pneumonia;Population;Positioning Attribute;Prevalence;programs;prospective;Protocols documentation;Pulmonary Emphysema;pulmonary function;quantitative imaging;radiological imaging;radiologist;Recommendation;reconstruction;Recording of previous events;recruit;Reporting;Research;Resource Allocation;respiratory;respiratory health;Respiratory Signs and Symptoms;Risk;Risk Estimate;Risk Factors;risk stratification;Scanning;screening program;Services;Smoking;Spirometry;standard of care;Standardization;Symptoms;System;Target Populations;Techniques;Technology;Telephone;Testing;Thick;Time;tool;Total Lung Capacity;Training;Translating;Translations;urgent care;Validation;Veterans;Veterans Health Administration;Visit;Visual

PROJECT_TITLE: Quantitative Imaging Analysis to Identify Chronic Respiratory Disease


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: VELLORE

ORG_COUNTRY: INDIA

ORG_FIPS: IN

ORG_NAME: CHRISTIAN MEDICAL COLLEGE

PHR: PROJECT NARRATIVE Soil transmitted helminths (STH) are a major public health problem worldwide, disproportionately affecting the poorest and most vulnerable communities. Intensive animal-human mixing with livestock and companion animals combined with poor hygiene and sanitation in these communities can lead to transmission of zoonotic infections as well as result in zoonotic sources of infections. Most epidemiological surveys and mathematical models of STH do not account for or measure the risk of infections acquired from zoonotic sources either by direct contact with animals or animal feces or indirectly from the environment. Our program aims to use a One Health framework to examine the interconnectedness between human, animal and environmental reservoirs of STH by integrating epidemiological, environmental and qualitative research data with state-of- art molecular techniques into species-specific transmission models to better inform monitoring and elimination strategies for this neglected tropical disease.

PI_NAMEs: AJJAMPUR, SITARA SWARNA RAO (contact);SARKAR, RAJIV

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Adult;Affect;Africa;Age;Animals;Anthelmintics;Ascaris lumbricoides;Ascaris suum;benzimidazole resistance;Canis familiaris;career;Characteristics;Child;Cluster randomized trial;Collection;Communities;companion animal;Complex;cost effective;Data;detection method;Diagnostic;diagnostic tool;DNA;DNA Library;Drug resistance;Effectiveness;Environment;Environmental Pollution;Epidemiology;Exposure to;Failure;Family suidae;Feces;Future;Geographic Locations;Geography;Goals;Health;helminth infection;Helminths;Hookworms;Household;Human;human disease;human DNA;Hybrids;Hygiene;improved;India;Individual;Infection;infection burden;infection risk;Interruption;Intervention;Laboratories;Livestock;Malaria;mathematical model;Measures;Medical Research;Microscopy;Modeling;Molecular;molecular diagnostics;Monitor;Morbidity - disease rate;Morphology;multidisciplinary;Necator americanus;neglected tropical diseases;nucleic acid detection;Nursery Schools;Old World Hookworm;Pattern;Performance;Persons;Pharmaceutical Preparations;Population;portability;Prevalence;prevent;programs;Public Health;Qualitative Research;Randomized, Controlled Trials;Recommendation;reproductive;Research;Research Personnel;Resistance;Resources;Role;Rural;rural residence;Sampling;Sanitation;School-Age Population;screening;Sequence Analysis;Sewage;Site;Soil;Source;Southeastern Asia;stool sample;success;Surveys;Techniques;Training;transmission process;Trichocephalus trichiura;Vector-transmitted infectious disease;vulnerable community;Water;Woman;Zoonoses

PROJECT_TITLE: Changing the Landscape of Soil Transmitted Helminth Infections in India Using a One Health Approach


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Project Narrative This project proposes the continued development and expansion of an innovative model of research education that addresses best practices for translational research in the field of child and adolescent behavioral health, as it relates to substance abuse and co-occurring disorders with an emphasis on at-risk populations including children and families of AI descent and Hispanic populations.

PI_NAMEs: LEVIN, BRUCE LUBOTSKY;MASSEY, OLIVER T (contact)

PROGRAM_OFFICER_NAME: DUCHARME, LORI

PROJECT_TERMS: Achievement;Address;Adolescent;Adolescent Development;adolescent drug abuse;adolescent substance use;American Indians;Arizona;Attention;Behavior Disorders;behavioral health;career;certificate program;Child;Clinical;Clinical Treatment;college;Communities;community based participatory research;Community Practice;Community Services;community setting;comorbidity;Competence;curriculum enhancement;Development;Disparity;Distance Learning;Drug abuse;dual diagnosis;Education;education research;Educational Curriculum;Emotional disorder;Evaluation;Evidence based practice;Evidence based program;experience;Family;Family health status;Family member;farm worker;Florida;Fostering;Foundations;Funding;Goals;Health Services Research;high risk population;high-risk adolescents;Hispanic Populations;Immigrant;implementation research;implementation science;implementation strategy;innovation;interest;Intervention;Journals;Knowledge;Leadership;learning outcome;marginalized population;member;Mental disorders;Mentors;Methods;Migrant;Minority;Minority Groups;Modeling;National Institute of Drug Abuse;Outcome;Participant;peer coaching;Peer Review;Policies;Population;Population Heterogeneity;Populations at Risk;post-pandemic;practical application;programs;Provider;Public Health;Publishing;Research;Research Methodology;Research Personnel;Research Project Grants;response;Risk;Role;rural area;service delivery;service learning;Services;skills;social media;Students;Substance abuse problem;substance use;Substance Use Disorder;success;symposium;Training;training opportunity;Translational Research;Translations;treatment research;Underrepresented Populations;Underserved Population;Universities;urban area;web site

PROJECT_TITLE: Institute for Translational Research Education (ITRE) in Adolescent Substance Use


ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: Peripheral arterial disease (PAD) affects over 20% of aged adults and is very common among Veterans due significant tobacco use. PAD is due to the progressive blockage of peripheral arteries, predominantly to the legs, and results in intermittent claudication (IC) or recurrent muscle pain with activity secondary to insufficient blood supply. Those with PAD and IC experience a progressive decline in walking and poor quality of life. There is no effective medical treatment for PAD and IC. Metformin is a safe and effective treatment for Type 2 diabetes but it can also reduce inflammation, oxidative stress, and improve energy requirements as well as improve blood flow to the legs. Therefore, we will test the ability of Metformin to improve overall functional status, reduce PAD progression, and reduce systemic inflammation in Veterans suffering from PAD and IC in a randomized, placebo controlled trial: Metformin BenefIts Lower Extremities with Intermittent Claudication (MOBILE IC) Trial. The success of this trial may identify a safe and effective treatment for PAD and IC.

PI_NAMEs: TZENG, EDITH  (contact)

PROJECT_TERMS: Address;Adult;Affect;age related;Age related comorbidities;Age Years;aged;aging related disease;Amputation;angiogenesis;Ankle;Arteries;Aspirin;atherogenesis;Atherosclerosis;blind;Blood flow;blood glucose regulation;Blood Platelets;blood pressure control;Blood Vessels;calcification;Cardiopulmonary;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cell Respiration;Chronic;Cilostazol;Clinic;Clinical;comorbidity;comparison group;Cross-Over Studies;Data;Disease;Disease Progression;DNA Damage;Dose;Drug Exposure;effective therapy;Effectiveness;effectiveness evaluation;Endothelium;Event;Exercise;exercise program;Exercise Test;Exercise Therapy;exosome;experience;Exposure to;extracellular;Female;follow-up;frailty;Functional disorder;functional improvement;functional independence;functional status;Gait abnormality;Glucose;Goals;Hand Strength;hazard;Health;health related quality of life;Health system;human old age (65+);improved;Incidence;indexing;Inflammation;Inflammatory;inflammatory marker;innovation;insight;Institution;Intention;Intermittent Claudication;Kidney Diseases;Leg;limb loss;Link;Lower Extremity;male;Malignant Neoplasms;Measures;Medical;Metformin;MicroRNAs;Mitochondria;mitochondrial dysfunction;Modeling;Morbidity - disease rate;mortality;Myalgia;Myocardial Infarction;neutrophil;Non-Insulin-Dependent Diabetes Mellitus;novel;Observational Study;older adult;Operative Surgical Procedures;Organ;Outcome;Oxidative Stress;Oxygen Consumption;Patient-Focused Outcomes;Patients;Peripheral;Peripheral arterial disease;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Phase;Physiologic pulse;Placebo Control;Placebos;Plasma;pleiotropism;preclinical study;prevent;primary outcome;Production;programs;prospective;Prospective Studies;Quality of life;Questionnaires;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Reactive Oxygen Species;Recurrence;Reporting;Reproducibility;Rest;Retrospective Studies;revascularization;revascularization surgery;Risk;secondary outcome;Secondary to;Smoking;smoking cessation;Stroke;success;Surveys;symptom treatment;symptomatic improvement;Symptoms;systemic inflammatory response;Testing;Time;Tobacco use;treatment group;Vascular blood supply;Vascular Diseases;vascular inflammation;Veterans;Walking;walking speed

PROJECT_TITLE: Metformin BenefIts Lower Extremities with Intermittent Claudication (MOBILE_IC)


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Lung;Physical Activity;Pulmonary Hypertension

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Heart failure with preserved ejection fraction (HFpEF) afflicts approximately 32 million people worldwide and the five year mortality and readmission rates from HFpEF are 75.7% and 84%, respectively. Pulmonary hypertension is very common in HFpEF (PH-HFpEF) and portends worse prognosis, yet no treatment exists to date. This proposal seeks to establish mitochondria targeted antioxidants as a potential treatment in PH-HFpEF and pave the way for large human studies to enhance health and reduce illness from PH-HFpEF.

PI_NAMEs: TRIANTAFYLLOU, GEORGIOS  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Acute;Anatomy;Animal Experiments;Animals;Antioxidants;Apoptosis;arterial stiffness;Blood capillaries;Blood Vessels;Calcium;Cardiac;career development;Cell Culture Techniques;Cell Proliferation;Cell Separation;Classification;Clinical Trials Design;Combined Modality Therapy;Cyclic GMP;Down-Regulation;Echocardiography;Educational workshop;effective therapy;EFRAC;Endothelium;Enzymes;Evaluation;Exercise;exercise intensity;Exercise Tolerance;Future;Generations;Genetic;Grant;GUCY1B3 gene;Health;Heart failure;heart failure with reduced ejection fraction;heart function;hemodynamics;Hospitalization;Human;human disease;human model;Hypertrophy;Impairment;improved;in vivo;Institute of Medicine (U.S.);Knowledge;Leadership;Learning;Left;Left Ventricular Function;Lung;Measures;Mentors;Metabolic syndrome;Methods;MicroRNAs;Mitochondria;Modeling;Molecular Biology Techniques;mortality;National Heart, Lung, and Blood Institute;Nuclear;nuclear factor Y;Obesity;Operative Surgical Procedures;Outcome;Oxidative Stress;Pathogenesis;Patients;Persons;Pharmaceutical Preparations;Physicians;Positioning Attribute;Pre-Clinical Model;preservation;pressure;Prognosis;Proliferating;Publishing;pulmonary arterial pressure;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular disorder;Pulmonary Vascular Resistance;pulmonary vasoconstriction;Pulmonary Wedge Pressure;Rattus;Reactive Oxygen Species;readmission rates;Research Personnel;Research Priority;Rest;Right Ventricular Function;Risk;Scientist;Signal Transduction;Signs and Symptoms;skills;Smooth Muscle Myocytes;Soluble Guanylate Cyclase;SU 5416;Syndrome;Technical Expertise;Testing;therapeutic target;Thinness;Training;transcription factor;Translations;ultrasound;United States National Institutes of Health;Universities;Vascular remodeling;Vasodilation;Wedge Pressures

PROJECT_TITLE: Targeting mitochondria-derived reactive oxygen species as a therapy for combined pre- and post-capillary pulmonary hypertension


NIH_SPENDING_CATS: Breast Cancer;Cancer;Hematology;Lung;Lung Cancer;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative These proposed studies have direct applicability to patients who fail to respond to palbociclib. Importantly, there are a variety of pharmacological inhibitors that are currently available targeting multiple components within the newly discovered signaling pathway that mediates palbociclib-induced senescence of lung cancer cells, some of which are clinically used for the treatment of non-cancer related diseases. Positive findings from the proposed research will lead to the identification of novel senolytic targets that can be used to circumvent palbociclib resistance, resulting in decreased tumor progression and improved overall survival in lung cancer patients.

PI_NAMEs: WANG, XIAO-FAN  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Adverse effects;Adverse event;Anticoagulants;Apoptosis;Aromatase Inhibitors;Attenuated;Automobile Driving;Binding;Bypass;Cancer cell line;Cancer Etiology;Cancer Patient;Cancer Relapse;cancer therapy;CDK4 gene;Cell Aging;Cell Cycle Arrest;Cell Cycle Regulation;Cell Proliferation;Cells;Cessation of life;chemotherapy;Clinical;Clinical Trials;Combined Modality Therapy;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinases;Diagnosis;Disease;Disease Progression;Endothelial Cells;Endothelium;Epithelial Cells;ERBB2 gene;Estrogen receptor positive;FDA approved;G1 Phase;Genetic Screening;Goals;Growth;Human;improved;In complete remission;In Vitro;in vivo;inhibitor;innovation;interest;Intervention;Left;Letrozole;Leukopenia;Lung;lung cancer cell;Malignant Breast Neoplasm;Malignant neoplasm of lung;Mediating;Medical;Metabolic;Metastatic breast cancer;Molecular;Names;neoplastic cell;Neutropenia;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;PAR-1 Receptor;partial response;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phase II Clinical Trials;Physical Function;preclinical efficacy;preclinical trial;programs;Progression-Free Survivals;Protein C;Radiation;receptor;Recurrence;Recurrent disease;Research;Resistance;Resistance development;response;Role;senescence;senescent cell;senolytics;Serine Protease;side effect;Signal Pathway;Signal Transduction;Solid Neoplasm;Stable Disease;Stimulus;Survival Rate;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Thrombin;Thrombomodulin;Toxic effect;transcriptomic profiling;Treatment Efficacy;tumor microenvironment;tumor progression;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Synthetic lethality by targeting the core senescent mechanism in lung cancer.


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Complementary and Integrative Health;Digestive Diseases;Immunotherapy;Microbiome;Rheumatoid Arthritis

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Autoimmune diseases affect ~50 million people in the US alone. Our goal is to engineer a probiotic for oral administration and release of an immunomodulator in the intestines.

PI_NAMEs: BEETON, CHRISTINE  (contact);BRITTON, ROBERT A;HYSER, JOSEPH M.

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acids;Address;adduct;Affect;analog;Animal Model;Anti-Inflammatory Agents;Autoimmune Diseases;Bacteria;Biodistribution;Biological Assay;Biological Products;Biological Response Modifier Therapy;Biomedical Engineering;Blood;bone;capsule;Caring;Cells;Cessation of life;Chromosomes;chronic autoimmune disease;Circulation;Clinical;Clinical Trials;Collagen Arthritis;cytokine;disability;Disease;Dose;Drug Kinetics;dysbiosis;Electrophysiology (science);Engineered Probiotics;Engineering;Enteral;Enzyme-Linked Immunosorbent Assay;Epithelium;Flow Cytometry;Functional disorder;Gastrointestinal tract structure;Genes;Goals;gut microbiome;healthy volunteer;Histology;Human;immune modulating agents;immunogenicity;Immunohistochemistry;Immunomodulators;immunoregulation;improved;In Vitro;in vivo;Injections;Intestinal permeability;Intestines;Joints;Lactobacillus reuteri;lymphoid organ;Marketing;Mass Spectrum Analysis;Mediating;Memory;Modeling;multidisciplinary;Multiple Sclerosis;National Institute of Allergy and Infectious Disease;Nature;nonhuman primate;novel;novel therapeutic intervention;novel therapeutics;Oral;Oral Administration;Organoids;Pathology;Patient Care;Patient Compliance;Patients;Peptides;Persons;Pharmaceutical Preparations;Phase;pilot trial;Population;Potassium Channel;prevent;pristane induced arthritis;probiotic therapy;Probiotics;Production;promoter;Property;radiological imaging;Rattus;recombinant peptide;Recombinants;Research Project Grants;response;Rheumatoid Arthritis;Rodent;Safety;Second Messenger Systems;Severities;side effect;Symptoms;T memory cell;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;Therapeutic;therapeutic evaluation;Tissues;TNF gene;treatment strategy;Venoms;Western Blotting;Work

PROJECT_TITLE: Engineered probiotic for the treatment of autoimmune diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-M(82)S]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Using a patho-epidemiology approach, we will address the overarching hypothesis that senescent stromal fibroblasts, especially if they elicit an inflammatory response, promote lethal prostate cancer. Our proposed work is designed to inform the pressing clinical need for identifying which men’s, including Black men’s prostate cancers are very likely to kill and, equally important, which ones are very unlikely to kill. Further, our proposed work is designed to inform novel therapeutics (senolytics) that eliminate senescent stromal fibroblasts in men at risk for progression to or already harboring metastatic disease.

PI_NAMEs: MEEKER, ALAN KEITH;PLATZ, ELIZABETH A. (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Address;Aging;androgen independent prostate cancer;anti-cancer research;Area;Autopsy;Biological Markers;black men;bone;Bone Tissue;cancer cell;cancer initiation;Castration;Cell Aging;Cell Death;cell type;Cellular biology;Cessation of life;chemotherapy;Clinical;clinically relevant;cohort;Cohort Studies;companion diagnostics;cytokine;Data;Death Rate;density;design;Detection;Development;Disease;Disease Progression;disorder risk;Enzymes;Epidemiology;Event;Excision;Exclusion;experience;Expression Profiling;FDA approved;Fibroblasts;follow-up;Fresh Tissue;Genetic;Genomics;Goals;Growth;Growth Factor;Heterogeneity;high risk;Hormones;Image;Image Analysis;immune cell infiltrate;Immunofluorescence Immunologic;In Situ;Inflammation;Inflammatory;Inflammatory Response;Institution;Lesion;Letters;Link;Malignant neoplasm of prostate;Malignant Neoplasms;man;Measures;men;Metastatic Prostate Cancer;Micrometastasis;Neoplasm Metastasis;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Performance;Pharmaceutical Preparations;Population;Primary Neoplasm;Productivity;Prognosis;prognostic assays;prognostic indicator;prognostic performance;prognostic tool;progression risk;Prostate;prostate cancer risk;Prostatectomy;Radiation therapy;Relative Risks;Research;Research Personnel;Resistance;senescence;senescent cell;senolytics;Series;Site;soft tissue;Stains;Stromal Cells;Telomere Shortening;Testing;Tissues;translational scientist;Treatment Effectiveness;tumor microenvironment;Work

PROJECT_TITLE: Stromal senescence in lethal prostate cancer: a novel target for prognosis and therapy

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative  Thoracic aortic aneurysm is a disease process involving degenerative dilation of the aorta leading to eventual rupture and death unless treated with complex surgical intervention. The proposed work aims to delineate the pathogenesis of aortic aneurysm at the cellular level while also exploring the pro-regenerative properties of extracellular matrix hydrogel in an animal model. Our ultimate goal of this research is to improve screening and surveillance of this patient population while also investigating potential regenerative therapies that halt the process of aneurysm formation.

PI_NAMEs: FISHER, BRYANT  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 3-Dimensional;Aneurysm;angiogenesis;Animal Model;Aorta;Aortic Aneurysm;Aortic Diseases;Biocompatible Materials;Biomechanics;Blood flow;blood vessel development;Blood Vessels;Calcium Chloride;Cell Death;Cessation of life;Clinical;Complex;Dilatation - action;Disease;Dissection;Elastases;Elastin Fiber;Endothelial Cells;Exhibits;Extracellular Matrix;Family suidae;Fibroblast Growth Factor;Functional disorder;functional improvement;Goals;Growth Factor;Histologic;Human;Hydrogels;Hypoxia;Impairment;improved;In Vitro;in vivo;inhibitor;Interruption;Knowledge;Medial;Modality;Modeling;Molecular;Morbidity - disease rate;mortality;new therapeutic target;novel therapeutics;Operative Surgical Procedures;Oryctolagus cuniculus;Pathogenesis;Pathway interactions;patient population;Perfusion;Pericytes;pharmacologic;platelet-derived growth factor BB;prevent;Process;Property;regeneration potential;regenerative;regenerative therapy;Research;Risk;Rupture;screening;Smooth Muscle Myocytes;spheroids;theories;Therapeutic;Therapeutic Effect;Thoracic aorta;Thoracic Aortic Aneurysm;Tissues;Transforming Growth Factor beta;Tunica Adventitia;vasa vasorum;Vascular Endothelial Growth Factors;Vasculogenic;Work

PROJECT_TITLE: Pericyte and Extracellular Matrix Dysfunction in Thoracic Aortic Aneurysm

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-P(20)L]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE The COVID-19 pandemic has led to a dramatic increase in use of telehealth for cancer care, which has facilitated access to care for many Americans, particularly rural individuals. We do not yet know on a national level where and for whom telehealth has potential to improve cancer care access, which we will examine, along with what patient, provider, or referral network factors are associated with actual telehealth use, and how telehealth use in cancer care impacts outcomes. Then we will estimate when telehealth use is most likely to improve cancer care equity for rural areas, and the diverse populations within those areas.

PI_NAMEs: ONEGA, TRACY  (contact);WANG, FAHUI

PROGRAM_OFFICER_NAME: RANDHAWA, GURVANEET

PROJECT_TERMS: access disparities;Address;Adoption;age group;American;Area;Automobile Driving;beneficiary;Black race;Bladder;Breast;cancer care;cancer health disparity;Cancer Patient;care coordination;care delivery;care outcomes;Catchment Area;Censuses;Clinical;cohort;Colon;Communication;COVID-19 pandemic;Data;Dimensions;disparity gap;disparity reduction;Emergency department visit;Equity;Fee-for-Service Plans;gaps in access;geographic difference;Geographic Locations;geographic population;geographically distant;Geography;health care availability;health care delivery;health care disparity;health disparity;health equity;Health Policy;Health Services;Health Services Accessibility;Hospitalization;improved;Inequity;inpatient service;Link;Lung;Malignant Neoplasms;Massachusetts;Measures;Medicare;Medicare claim;Melanoma;Methodology;Methods;Modeling;mortality;mortality disparity;novel;Outcome;Pancreas;Patients;Pattern;Policies;Population;population based;Population Characteristics;Population Heterogeneity;pre-pandemic;Provider;Rectum;Rural;rural area;rural cancer care;Rural Population;Service delivery model;Services;Signal Transduction;sociodemographics;South Dakota;Specialist;Subgroup;symptom management;telehealth;Telemedicine;Testing;Time;Transcend;Travel;Treatment Protocols;uptake;Urban Population;virtual;Visit;Work

PROJECT_TITLE: Access, Utilization and Outcomes of Cancer Services in the Era of Telemedicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-N(02)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Hepatitis - B;Immunization;Immunotherapy;Infectious Diseases;Liver Disease;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Hepatitis B virus (HBV) remains a major global health problem and a leading cause of liver cirrhosis and hepatocellular carcinoma. While antiviral therapies achieve long-term viral suppression, they can rarely clear infection or induce a state of long-term control of infection after treatment is discontinued. Efforts to identify strategies to eradicate or induce treatment-free long-term HBV remission are critical.

PI_NAMEs: CASKEY, MARINA  (contact)

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: Acceleration;acute infection;adaptive immune response;Aftercare;Amino Acids;analog;Animal Model;Animals;Anti-viral Agents;Anti-viral Therapy;Antibodies;Antigen-Antibody Complex;Antigens;B-Lymphocytes;Binding;cancer cell;cancer therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell-Mediated Cytolysis;Cells;Cellular Immunity;Chronic;Chronic Hepatitis B;chronic infection;Circular DNA;Clinic;Clinical;Clinical Research;cross reactivity;Development;Disease remission;DNA Integration;Dose;Drug Kinetics;Epitopes;Event;exhaustion;experience;Experimental Models;experimental study;Exposure to;extracellular;Fc domain;first-in-human;Fostering;Genome;global health;Half-Life;Hepatitis B Antibodies;Hepatitis B e Antigens;Hepatitis B Surface Antigens;Hepatitis B Virus;HIV-1;Human Biology;human monoclonal antibodies;human study;Humoral Immunities;IgG1;Immune;Immune response;Immunity;Immunologics;immunoregulation;Immunotherapy;Impairment;In Vitro;in vivo;Individual;Infection;Infection Control;Inflammation;inflammatory marker;Innate Immune Response;Liver;Liver Cirrhosis;manufacture;Measures;Mediating;Membrane;Modeling;Modification;Monoclonal Antibodies;nano;neutralizing antibody;nonhuman primate;novel therapeutic intervention;Passive Transfer of Immunity;peripheral blood;Persons;Phagocytosis;Pharmacologic Substance;Primary carcinoma of the liver cells;Rattus;Recombinants;Recovery;recruit;response;restoration;Role;Safety;seroconversion;Serotyping;Serum;T-Lymphocyte;Testing;Therapeutic;Tissues;Transgenic Mice;Vaccination;Vaccinee;Variant;Viral;Viral Antigens;Viral Physiology;viral RNA;Viremia;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: First-in-human study of a potent anti-HBsAg neutralizing antibody


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Machine Learning and Artificial Intelligence;Microbiome;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: PROJECT NARRATIVE Chemical and toxic substances, such as herbicides and pesticides pose some of the most common threats to environmental and human health. Our studies are designed to identify effects of prenatal pesticide exposure on child neurodevelopment and the role of the gut microbiome in mediating pesticide-induced adverse health effects. Findings of our study will ultimately result in precision risk assessment and precision prevention strategies to improve human health worldwide.

PI_NAMEs: MAO, JIAN-HUA  (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: 16S ribosomal RNA sequencing;4 year old;acaricide;Affect;Anxiety;Artificial Intelligence;Atrazine;Bacteria;Behavior;Behavioral;Bioinformatics;Biological;biological systems;Birth;Body System;Brain;brain tissue;C57BL/6 Mouse;carcinogenesis;Chemical Exposure;Chemicals;Child;Child Development;Child Health;China;Chinese;Chlorpyrifos;cognitive performance;cohort;Data;Data Analyses;Data Collection;Degradation Pathway;design;Development;Developmental Delay Disorders;Diet;Dose;drinking water;Environment;Environmental Exposure;Environmental Risk Factor;Etiology;experimental study;Exposure to;Failure;Family health status;follow-up;Food Supply;Germ-Free;glyphosate;Gnotobiotic;Growth;gut bacteria;gut microbiome;gut microbiota;Health;Health Personnel;Herbicides;high risk;Human;immunodeficiency;improved;Individual;individual variation;individualized prevention;Industrialization;Insecticides;Intervention;Lead;Life;Link;Manuscripts;Measures;Mediating;Medical;Memory;microbial;microbial community;microbial composition;microbiome;microbiome analysis;microbiome components;microbiome composition;microbiome sequencing;Moods;Mothers;Motor;motor behavior;mouse model;Mus;neurodevelopment;novel;offspring;Organ;Outcome;Paraquat;Participant;Pathway interactions;Pentachlorophenol;Performance;Persons;pesticide exposure;Pesticides;Phenotype;Phorate;Physiology;Play;Poison;Predisposition;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal environmental exposure;prenatal exposure;Prevention strategy;Probiotics;Public Health;recruit;response;Risk;Risk Assessment;risk prediction model;Role;sample collection;Second Pregnancy Trimester;Serum;Social Interaction;stool sample;Taxonomy;Testing;Toxic effect;transcriptome sequencing;United States;Universities;Validation;Water Supply

PROJECT_TITLE: Role of the gut microbiome in pesticide-induced effects on child neurodevelopment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(50)R]


ORG_CITY: LEXINGTON

ORG_NAME: VA MEDICAL CENTER - LEXINGTON, KY

ORG_STATE: KY

PHR: The increase in inflammatory bowel disease (IBD) among veterans in recent years presents a significant clinical problem in the VA healthcare system. Major concerns for IBD veteran patients are the increased disease morbidity and risk of therapies. Further research is needed to develop safe and effective agents that enhance mucosal repair and reduce immune-suppression. Previous work from our lab has indicates that mitochondrial respiration promotes ulcer healing. This finding led us to postulate that increasing mitochondrial respiration constitutes a novel therapeutic goal in IBD. To improve mitochondrial function in IBD, we developed AuPhos, an oral agent that enhances mitochondrial electron transport that potentiates mitochondrial bio-energetics and mitochondrial reactive oxygen species (mtROS) production. The current project will ascertain the impact of this novel gold compound (AuPhos) on mitochondrial function and ulcer healing in mouse models of colitis as well as biopsy tissue explants from veterans with IBD.

PI_NAMEs: BARRETT, TERRENCE A. (contact)

PROJECT_TERMS: 3-Dimensional;3-nitrotyrosine;Acceleration;antioxidant enzyme;Antioxidants;Auranofin;Bioenergetics;Biogenesis;Biopsy;catalase;Cell Survival;Cells;Childhood;Chronic;chronic ulcer;Clinical;Clinical Data;Colitis;Colon;Crohn's disease;cytokine;Data;dextran sulfate sodium induced colitis;Disease;Disease Outcome;Disease remission;Distant;Electron Transport;enzyme activity;Epithelial Cells;Event;Failure;Gene Expression;Genes;Glutathione;Goals;Gold;Gold Compounds;healing;Healthcare Systems;Human;Hydrogen Peroxide;Immunosuppression;improved;In Vitro;in vivo;Incubated;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;intestinal crypt;intestinal epithelium;Intestines;Messenger RNA;Mitochondria;Modeling;Morbidity - disease rate;mtTF1 transcription factor;Mucositis;Mucous Membrane;murine colitis;Mus;novel;novel therapeutics;nuclear factor-erythroid 2;Oral;Organ;Organoids;Outcome;oxidant stress;Oxidative Phosphorylation;Oxidative Stress;Oxygen Consumption;Patients;Pharmaceutical Preparations;Phosphatidylinositols;Phosphotransferases;PPAR gamma;preclinical study;Production;Progress Reports;prospective;protein expression;Proteins;Reactive Oxygen Species;Refractory;repaired;Research;Respiration;Respiratory Chain;response;restoration;Rheumatoid Arthritis;Risk;Role;Secondary to;Signal Induction;Signal Transduction;single-cell RNA sequencing;Small Intestines;SOD2 gene;Superoxide Dismutase;synergism;Testing;Therapeutic;Therapeutic Effect;Therapeutic Studies;Tissues;TNF gene;Toxicology;Ulcer;Ulcerative Colitis;uptake;Veterans;Work

PROJECT_TITLE: Modulation of mitochondrial respiration to treat colitis


NIH_SPENDING_CATS: Congenital Structural Anomalies;Lung;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative This project focuses on mesenchymal BMP signaling in regulating fetal lung morphogenesis and its relevance to congenital pulmonary airway malformation, a human disease with perinatal mortality ranging from 9% to as high as 49%. In particular, novel mechanisms by which mesenchymal BMP signaling pathway regulates airway smooth muscle cell growth, elastin expression, and epithelial progenitor commitment during lung development will be determined in new mouse models, which are impossible to be studied in human patients. Our proposed project will not only reveal the pathogenic mechanisms underlying prenatal pulmonary cysts, but also lay the foundation for future development of intervention and prevention strategies.

PI_NAMEs: SHI, WEI  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: airway epithelium;Black race;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;Cell Differentiation process;cell growth;Childhood;Cre lox recombination system;Cyst;Cystic Lesion;Defect;Development;Distal;Elastin;Elastin Fiber;Embryo;Enhancers;Environmental Risk Factor;Epithelial Cells;epithelial stem cell;Epithelium;fetal;Fetal Lung;Foundations;Future;Gases;Gene Expression;Genetic;Genetic Models;Growth;Growth Factor;Health;Histologic;Human;human disease;In Vitro;in vivo;Intervention;Intracellular Signaling Proteins;Knock-out;Knockout Mice;Ligands;Lung;lung development;Lung Diseases;malformation;Mediating;Mesenchymal;Mesenchyme;Molecular;Morbidity - disease rate;Morphogenesis;mortality;mouse genetics;mouse model;Mus;Neonatal;neonatal morbidity;Neonatal Mortality;novel;Organogenesis;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Perinatal mortality demographics;Play;Pregnancy;prenatal;Prevention strategy;Process;Production;progenitor;Respiratory Disease;respiratory smooth muscle;Role;Signal Pathway;Signal Transduction;Signaling Protein;Smooth Muscle Myocytes;stem cell expansion;Structure;Study models;surfactant production;System;therapy development;tool;Transcription Coactivator;Transgenic Organisms

PROJECT_TITLE: Lung Development and Diseases

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anorexia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric;Physical Activity;Serious Mental Illness

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Anorexia nervosa (AN) is a severe and treatment-resistant psychiatric illness of unknown etiology, with pernicious and alarming symptoms such as driven exercise. This study is novel in its use of decision tasks and neuroimaging to index reward and reinforcement learning among adolescents with AN, specifically in an effort to elucidate biobehavioral factors that determine for whom and why driven exercise may arise and be maintained. A mechanistic understanding of the processes that contribute to heterogeneity in AN symptomology will assist in informing precision treatment development.

PI_NAMEs: GORRELL, SASHA CATHERINE (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescent;Age;Anhedonia;Anorexia Nervosa;Behavior;Behavior assessment;Behavior Control;Behavior Disorders;behavior measurement;Behavioral;behavioral response;biobehavior;Brain;brain based;Brain region;burden of illness;career;Chronic;cognitive neuroscience;comparison control;Compulsive Behavior;computer framework;cost;Cues;Dangerousness;Data;Death Rate;Eating Disorders;Emotions;Etiology;Exercise;experience;Food;frontal lobe;Functional Magnetic Resonance Imaging;Future;Goals;Heterogeneity;Impairment;improved;indexing;Individual;Interruption;Intervention;Knowledge;Learning;Link;Mental disorders;Mentored Patient-Oriented Research Career Development Award;Mentorship;Modeling;mortality;Negative Valence;neural;neural correlate;Neurobiology;neuroimaging;novel;Nucleus Accumbens;Obsessive-Compulsive Disorder;Participant;Pathway interactions;Performance;Phenotype;Population;Positive Valence;Precision therapeutics;Process;Psychological reinforcement;Psychopathology;psychosocial;Recording of previous events;relapse risk;Research;Research Design;Research Domain Criteria;Resistance;response;reward processing;Rewards;skills;Stimulus;Subgroup;suicidal risk;Symptoms;System;Task Performances;Testing;therapy development;Training;translational neuroscience;Treatment outcome;United States National Institutes of Health;Weight;Work

PROJECT_TITLE: Neural Correlates of Reinforcement Learning Specific to Hyperactivityin Adolescent Anorexia Nervosa

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Mental Health;Palliative Care;Patient Safety

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Patients with dementia represent the fastest growing population of hospice users in the U.S. and account for a quarter of all hospice spending. Behavioral symptoms such as agitation, anxiety, and hallucinations are nearly universal in advanced dementia and, despite limited evidence to support their use, the mainstay of such symptom management in hospice is off-label use of psychotropic medications. Given the growing number of patients with dementia enrolling in hospice services, a better understanding of 1) the factors that influence psychotropic prescribing in hospice (including patient and caregiver preferences), and 2) the intended and unintended outcomes of such use, are critical in order to inform caregiver, provider, and policy decisions regarding appropriate use of psychotropic medications in end-of-life care for dementia.

PI_NAMEs: GERLACH, LAUREN BETH (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Acceleration;Accounting;Address;advanced dementia;Adverse event;Age;Agitation;anti-depressive agents;Antipsychotic Agents;Anxiety;Award;Behavior;Behavioral Symptoms;beneficiary;Benefits and Risks;Benzodiazepines;career;Caregivers;Caring;Characteristics;Clinical;clinical training;Clinical Trials;Consensus;Data;Data Set;Decision Making;Dedications;Delirium;Dementia;dementia care;design;Distress;Drug Prescriptions;Elderly;end of life;end of life care;Enrollment;Equilibrium;Evaluation;evidence base;Foundations;functional decline;Functional impairment;functional improvement;geriatric mental health;Geriatric Psychiatry;Goals;Growth;Hallucinations;Haloperidol;Hospice Care;hospice environment;hospice utilization;improved;Individual;innovation;Inpatients;Interview;K-Series Research Career Programs;Knowledge;Life;Link;loved ones;male;Measures;Medical;Medicare;Mental disorders;Mental Health Services;Mentors;Mentorship;Methods;Modeling;mortality;Mortality Decline;multilevel analysis;Nursing Homes;off-label use;older adult;Outcome;Palliative Care Nursing;Palliative Medicine;participant enrollment;Patient Care;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacoepidemiology;Policies;Population;preference;programs;Provider;Psychiatrist;public health relevance;Qualitative Research;Quality of Care;Research;Research Methodology;Research Personnel;Risk;Scientist;Services;sex;skills;Social support;stakeholder perspectives;Standardization;Statistical Methods;Structure;Surveys;symptom management;Symptoms;Terminally Ill;Training;Training Programs;Variant;Work

PROJECT_TITLE: Medicating distress: Use of psychotropic medications among patients with dementia receiving hospice care

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative The Cancer Genome Atlas (TCGA) reveals that SETD2 mutation is associated with poor prognosis and survival in ccRCC patients, and although there are links to genome instability and DNA methylation, the direct connection between SETD2 mutation and ccRCC remains unclear. This project aims to use chromatin immunoprecipitation followed by sequencing (ChIP-seq) studies of ccRCC cell lines and patient derived xenograft (PDX) models along with an array of biochemical and cellular assays to determine if loss of SETD2 protein is molecularly distinct from loss of its enzymatic activity. A deeper understanding of whether the specific location of a chromatin-modifying protein plays a critical role in determining the physiological outcome of the mutation will facilitate progress towards patient-tailored and genotype-specific drug therapies.

PI_NAMEs: DHAR, SHILPA  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Affect;amino group;Biochemical;Biological Assay;Cancer Biology;Cancer Patient;cancer subtypes;Cell Line;Cells;Cellular Assay;Cellular Morphology;Characteristics;chemotherapy;ChIP-seq;Chromatin;chromatin immunoprecipitation;Clear cell renal cell carcinoma;Clinical;clinically relevant;cohort;Collaborations;Complex;CRISPR/Cas technology;Data;Deposition;Development;Diagnosis;Discipline;Disease;Disease remission;Disease-Free Survival;DNA Methylation;Environment;Epigenetic Process;experimental study;Fellowship;Fostering;Functional disorder;Genetic Transcription;Genomic Instability;Genotype;Goals;grasp;histone modification;Histone-Lysine N-Methyltransferase;Histones;improved;insight;Intercistronic Region;Kidney Neoplasms;knock-down;Laboratories;Length;Link;Literature;Location;loss of function;Lysine;Malignant Neoplasms;Mediating;methyl group;Methyltransferase;Missense Mutation;Modeling;Molecular;multidisciplinary;mutant;Mutate;Mutation;novel therapeutics;Outcome;Ownership;patient derived xenograft model;Patients;Peptide Fragments;Pharmacotherapy;Physiological;Play;Precision therapeutics;Process;Prognosis;Protein Fragment;protein structure;Proteins;Radiation therapy;Renal Carcinoma;repaired;Reproductive Biology;Research;Resistance;response;RNA Polymerase II;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Scientist;SET Domain;Shapes;System;The Cancer Genome Atlas;Therapeutic;therapeutic development;Training;Transcript;tumor;tumorigenesis;United States;wound healing

PROJECT_TITLE: Contributions of SETD2 mutations in clear cell renal cell carcinoma (ccRCC)


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity

ORG_NAME: UNIVERSITY OF KENTUCKY

PHR: During obesity, visceral fat tissue expands causing oxidative stress and the release of pro-inflammatory cytokines that can cause insulin resistance and cardiovascular complications. This project explores the antioxidant bilirubin in molecular detail as a signaling molecule to reduce adiposity and insulin resistance and improve metabolic health. A comprehensive investigation of the signaling preferences for bilirubin may open new avenues for potential new therapeutics for obesity and insulin resistant diabetes, and for cardiovascular diseases in humans.

PI_NAMEs: HINDS, TERRY D (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Adenovirus Vector;Adipocytes;Adipose tissue;Adult;Affect;Antioxidants;Attenuated;Bile fluid;Bilirubin;Biliverdin reductase;Biliverdine;Binding;Blood;Blood Glucose;Body Weight;Body Weight decreased;carbohydrate metabolism;Cardiovascular Diseases;Cardiovascular system;Cell Size;clinically relevant;comparison control;cost;Crigler-Najjar Syndrome;cytokine;Data;Deposition;Diabetes Mellitus;Energy Intake;Energy Metabolism;Enzymes;Event;Excretory function;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Fenofibrate;fibroblast growth factor 21;Genes;Genetic;Genetic Polymorphism;Gilbert Disease;Glucose;Glucose Intolerance;Health;Health Expenditures;Hepatic;Hepatocyte;Hepatotoxicity;High Fat Diet;hormonal signals;Hormones;Human;humanized mouse;Hyperbilirubinemia;Icterus;improved;Inflammatory;Inherited;Insulin;Insulin Resistance;insulin sensitivity;Intestines;Investigation;Knock-out;Knockout Mice;Knowledge;Ligands;lipid metabolism;Lipids;Liver;Liver diseases;LoxP-flanked allele;Measures;Mediating;Metabolic;Metabolic hormone;Metabolism;microRNA delivery;MicroRNAs;Molecular;mouse model;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nuclear Receptors;Obese Mice;obese patients;Obesity;Obesity associated disease;Obesity Epidemic;Outcome;Overweight;oxidation;Oxidative Stress;Pathologic;Pathway interactions;Patients;Peripheral;Peroxisome Proliferator-Activated Receptors;Physiological;Plasma;Population Study;PPAR alpha;preference;Process;promoter;Protein Isoforms;Publications;recruit;Resistance;Risk;Rodent;Serum;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;Testing;Therapeutic;Tissue Expansion;Tissues;Transactivation;transcription factor;UDP-Glucuronosyltransferase 1A1;Uncertainty;United States;Visceral fat;Weight Gain

PROJECT_TITLE: Novel Liver Signaling Pathways Controlling Adiposity

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Immunotherapy;Rare Diseases;Tuberous Sclerosis

PHR: PROJECT NARRATIVE mTOR plays a critical role in integrating cues from the immune microenvironment to regulate T cell activation, differentiation and function. In this proposal, we will dissect the role of a novel mechanism by which the immune microenvironment regulates mTORC1 in T cells. Our studies have important implications not only for basic T cell biology but also for vaccine development as well as the development of novel immunotherapies for cancer.

PI_NAMEs: PEARCE, ERIKA L (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Adoptive Cell Transfers;Attenuated;cancer immunotherapy;Cardiac Myocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;Cell Physiology;Cellular biology;Cues;Cyclic GMP-Dependent Protein Kinases;Development;Effector Cell;effector T cell;Engineering;Exhibits;FRAP1 gene;Generations;Genetic;Goals;Guanosine Triphosphate Phosphohydrolases;Heart;Heart Diseases;Heart failure;Helper-Inducer T-Lymphocyte;Heterozygote;Human;Hyperactivity;Hypoxia;Immune signaling;improved;in vivo;Infection;insight;Knock-in Mouse;Malignant Neoplasms;Memory;Metabolic;mimetics;mortality;Mus;mutant;Mutate;Mutation;novel;Outcome;Pathway interactions;Phenotype;Phosphorylation;Phosphorylation Site;Play;pressure;prevent;Protein-Serine-Threonine Kinases;Proteins;ras GTPase-Activating Proteins;Reactive Oxygen Species;Regulation;Rest;Role;Serine;Signal Pathway;Signal Transduction;Site;Stress;T cell differentiation;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;treatment strategy;Tuberous Sclerosis;tumor;tumor-immune system interactions;vaccine development;Virus

PROJECT_TITLE: Phosphorylation of TSC2 (S1365) as a novel Regulator of mTORC1 Signaling in T Cells

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Digestive Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Acute and chronic pancreatitis are vexing diseases afflicting millions of people in the US. Our goal is to identify mechanisms underlying adaptive vs. oncogenic acinar-ductal metaplasia as a basis for understanding pancreatic tissue regeneration, critical for new therapeutics.

PI_NAMEs: RUSTGI, ANIL K (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: 3-Dimensional;Acinar Cell;acute pancreatitis;Animals;Biological Process;Biology;Cell Compartmentation;cell regeneration;Cell Reprogramming;Cells;Chromatin;chronic pancreatitis;Coculture Techniques;conditional knockout;confocal imaging;Cues;Data;Dependence;Development;Disease;Duct (organ) structure;Ensure;Epigenetic Process;Epithelial Cells;Epithelium;Esophagus;experimental study;Fibroblasts;Fos-Related Antigens;FOSL1 gene;Fostering;Gatekeeping;Gene Expression Regulation;Genetic Transcription;Goals;Heterogeneity;Histology;Homeostasis;Immune;Immunofluorescence Immunologic;in vivo;Inflammatory;Injury;innovation;insight;Knockout Mice;Mediating;Mediator;member;Metaplasia;Modeling;Molecular;Mus;mutant;Neoplasms;novel;novel therapeutics;Oncogenic;Organoids;Pancreas;Pancreatic Intraepithelial Neoplasia;Pancreatitis;Persons;Preneoplastic Conditions;Process;programs;Publishing;regenerative;Regulation;response;Role;single cell genomics;single-cell RNA sequencing;Stomach;Testing;Tissue Preservation;tissue regeneration;Tissues;transcription factor;Transcription Factor AP-1;Transcriptional Regulation;transcriptomics;transdifferentiation

PROJECT_TITLE: Networks for functional regulation of pancreatic acinar-ductal metaplasia and epithelial plasticity

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: The clinical, social, and financial impact of ineffectively treated Post-Traumatic Stress Disorder (PTSD) are enormous. New pharmacological interventions in combination with first-line trauma-based psychotherapy such as Prolonged Exposure (PE) carries great potential to address the limited efficacy of current pharmacological options. This project will conduct a randomized clinical trial investigating the efficacy and safety to use small doses of the anesthetic ketamine to augment PE therapy among veterans with PTSD. The goal of this intervention is to accelerate the reduction of PTSD symptoms and commonly co-occurring symptoms such as anxiety and depression.

PI_NAMEs: SHIROMA, PAULO R. (contact)

PROJECT_TERMS: Acceleration;active duty;Acute;acute traumatic stress disorder;Address;Adherence;Adjuvant Analgesic;Aftercare;Agreement;Amygdaloid structure;Anesthetics;Anxiety;anxiety reduction;anxiety symptoms;Area;associated symptom;Biological Process;Blood;Brain;Clinical;Clinical Data;Clinical Practice Guideline;Clinical Trials;cognitive performance;comorbid depression;comorbidity;Complex;conditioned fear;Consent;Data;depressive symptoms;Diagnosis;diagnostic criteria;Disease;Disease remission;Dose;Dropout;Drops;efficacy evaluation;Enrollment;Extinction;FDA approved;fear memory;Female;Financial Hardship;follow-up;Foundations;Frequencies;Fright;Glutamates;Goals;Hour;improved;Individual;Infusion procedures;Intervention;Interview;Joints;Ketamine;learning extinction;Manuals;Measures;Medial;medication administration;Memory;Mental Depression;Methodology;Midazolam;Military Personnel;military veteran;Modeling;Mood Disorders;Multicenter Studies;N-Methylaspartate;Neuronal Plasticity;Neurons;Nootropic Agents;Outcome;Outcome Measure;Paroxetine;patient retention;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Pilot Projects;Placebos;Population;Post-Traumatic Stress Disorders;pre-clinical;pre-clinical assessment;Prefrontal Cortex;primary outcome;Property;Proteins;Psychotherapy;randomized, clinical trials;Recommendation;reduce symptoms;Relapse;Research;Residual state;response;Rodent;Safety;secondary outcome;Sertraline;Severities;side effect;Site;social;Standardization;Symptoms;Synapses;Therapeutic;Therapeutic Effect;Time;Training;Trauma;trauma exposure;Trust;Veterans

PROJECT_TITLE: Repeated Ketamine Treatment to Accelerate Efficacy of Prolonged Exposure in PTSD


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Healthcare providers still rely heavily on opioid narcotics for post-operative pain control despite growing evidence of their risks of longer-term problems. Several novel brain stimulation technologies including transcranial direct current stimulation (tDCS) are beginning to demonstrate promise as treatments for a variety of pain conditions including perioperative pain. Another non-pharmacologic approach to pain management with minimal risks and good potential benefit is cognitive behavioral therapy for pain (CBT-P). CBT-P has consistently demonstrated solid empirical support as an effective treatment for chronic pain, but it is less well- studied in perioperative settings. Accumulating data from our group suggest that tDCS of the prefrontal cortex may augment the analgesic effects of cognitive-behavioral (CB) interventions for acute pain. The proposed study will be the first ever to determine the effects of combining tDCS with a brief cognitive-behavioral intervention on post-operative pain, opioid use and functioning following TKA.

PI_NAMEs: BORCKARDT, JEFFREY J (contact)

PROJECT_TERMS: Acute Pain;Acute pain management;addiction;Age;Analgesics;Area;Arthritis;Behavioral;Behavioral Sciences;Brain;chronic pain management;Clinical Trials;Cognition;Cognitive;cognitive benefits;Cognitive Therapy;Confusion;Controlled Study;Data;Development;Drug Delivery Systems;Drug Interactions;Educational process of instructing;effective therapy;Electricity;Fatigue;functional status;Health Personnel;Healthcare;Hour;Human;improved;innovation;Intervention;knee pain;knee replacement arthroplasty;Laboratory Study;Length of Stay;Methods;minimal risk;Modernization;Morbidity - disease rate;mortality;Motility;Narcotics;neural circuit;Neurosciences;Nonpharmacologic Therapy;novel;Operative Surgical Procedures;Opioid;Opioid Analgesics;opioid epidemic;opioid misuse;opioid use;Orthopedic Procedures;Orthopedic Surgery;Outcome;Pain;Pain management;pain reduction;pain relief;Participant;Patients;Pattern;Perioperative;Persistent pain;Pharmaceutical Preparations;Physical therapy;Pilot Projects;Population;Postoperative Complications;Postoperative Pain;Postoperative Period;Practice Management;Prefrontal Cortex;prescription opioid;Prevalence;Procedures;Psyche structure;Quality of life;Recovery;Regimen;Reporting;Risk;Series;side effect;Solid;Stomach;surgery outcome;Techniques;Technology;Time;transcranial direct current stimulation;Transcranial magnetic stimulation;treatment effect;Ventilatory Depression;Veterans;Work

PROJECT_TITLE: tDCS Combined with a Brief Cognitive Intervention to Reduce Perioperative Pain and Opioid Requirements in Veterans


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Sleep Research

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative While it is suggested that a functional role of sleep is to stabilize and improve visual learning, its underlying neural mechanism is poorly understood. Using advanced non-invasive neuroimaging techniques and careful behavioral measurements, we aim to better understand the mechanisms. Successful research results may give us insights into how learning can be improved through sleep and how vision declined or damaged due to aging, injury or diseases could be improved.

PI_NAMEs: SASAKI, YUKA  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Aging;Applications Grants;Area;behavior measurement;Brain;Clinical;clinical training;Development;Disease;experience;extrastriate visual cortex;gamma-Aminobutyric Acid;Glutamates;Glutamine;Human;improved;Injury;insight;Learning;Left;Magnetic Resonance Spectroscopy;Measures;mesolimbic system;Methods;Monkeys;neuroimaging;neuromechanism;non rapid eye movement;Perceptual learning;Performance;Pilot Projects;Play;Polysomnography;Prefrontal Cortex;Process;Psychophysics;REM Sleep;Research;resilience;retinotopic;reward processing;Rewards;Role;Signal Transduction;Sleep;Sum;Techniques;Testing;tool;Training;Training Programs;Vision;Visual;visual learning

PROJECT_TITLE: Roles of Non-REM and REM sleep in facilitating visual perceptual learning

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative Conventional DBS is an effective therapy for Parkinson's disease (PD), but its therapeutic effects decay rapidly once stimulation is turned off, underscoring the fact that it masks symptoms but does not reverse underlying circuit dysfunction. Based on foundational research into the cell-type organization of basal ganglia circuits, this proposal develops and tests the therapeutic efficacy of electrical stimulation protocols designed to selectively recruit therapeutic cell populations within the external globus pallidus (GPe) of the basal ganglia. The collaborative project will test the efficacy and therapeutic duration of novel stimulation protocols in mouse and primate models of PD.

PI_NAMEs: GITTIS, ARYN HILARY (contact);TURNER, ROBERT STERLING

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Acute;Anatomy;Animal Model;attenuation;Basal Ganglia;battery life;Behavioral;Biological Assay;Brain;Cell Nucleus;cell type;Cells;Clinical;clinical application;Complex;Consumption;cost;Data;Deep Brain Stimulation;design;Devices;Dissociation;Dopamine;effective therapy;efficacy testing;Electric Stimulation;Ensure;experimental study;extracellular;Frequencies;Functional disorder;Globus Pallidus;high dimensionality;Homeobox;Hour;Human;Immobilization;in vivo;insight;Intervention;Knowledge;Machine Learning;Maps;Masks;Mediating;Modeling;Motor;motor deficit;motor recovery;motor symptom;mouse model;Movement;Mus;Nature;Nervous System;neural patterning;Neurons;neuroregulation;nonhuman primate;novel;novel therapeutic intervention;optogenetics;Output;Oxidopamine;Parkinson Disease;Parkinsonian Disorders;Parvalbumins;Pathologic;Patients;Pattern;Phase;Physiological;Physiology;Population;pre-clinical;predictive modeling;Primates;Protocols documentation;rational design;recruit;reduce symptoms;Research;Resolution;response;Risk;side effect;Site;Slice;Solid;STN stimulation;Structure of subthalamic nucleus;Symptoms;Synapses;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Time;Translating;translation to humans;Treatment Efficacy;Whole-Cell Recordings

PROJECT_TITLE: DBS Protocols for Long-Lasting Therapeutic Benefit in Mouse and Primate Models of Parkinson's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: This proposal seeks to define the role of ubiquitination in tau oligomers formation, secretion and propagation in neurons during Alzheimer’s disease in humans and mice. By understanding this process, we may be able to develop new treatment strategies that prevent this process and thus slow, or even halt, the progression of Alzheimer’s disease.

PI_NAMEs: KAYED, RAKEZ  (contact);ZHAO, YINGXIN

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease therapy;American;Amino Acids;Appearance;Astrocytes;Binding;Biochemical;Biological Markers;brain cell;Brain region;C-terminal;Cell Culture Techniques;Cells;cognitive function;Deubiquitination;Disease;Disease Progression;Economic Burden;Exhibits;extracellular;Functional disorder;Goals;hTau Mice;Human;Impaired cognition;In Vitro;in vivo;Isotope Labeling;Knowledge;Lysine;MAPT gene;Mass Spectrum Analysis;Mediating;Microglia;Microtubules;Modeling;Modification;Molecular;Monoubiquitination;multicatalytic endopeptidase complex;Multivesicular Body;Mus;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;Neurons;neurotoxic;neurotoxicity;new therapeutic target;non-demented;novel;novel therapeutic intervention;Pathogenesis;Pathologic;Pathology;Pathway interactions;Pattern;Phosphorylation;Physiological;Polyubiquitination;Population;Post-Translational Protein Processing;prevent;prion-like;Process;Proteins;Proteomics;proteostasis;Regulation;Reporting;Research Design;Role;Series;Signal Transduction;Site-Directed Mutagenesis;socioeconomics;Stable Isotope Labeling;Synapses;Synaptic Transmission;System;tau aggregation;tau Proteins;Tauopathies;Testing;Therapeutic;Toxic effect;trafficking;Ubiquitin;ubiquitin isopeptidase;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: The Role of Ubiquitination in Tau Oligomers Pathogenesis

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Pediatric;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The Atlanta Pediatric Scholars Program will train physician-scientists in fundamental research on child-health related problems. This career development program is a collaboration between Emory University and Children's Healthcare of Atlanta. The program seeks to train a diverse group of outstanding, independent physician-scientists to be the next generation of leaders in pediatric research.

PI_NAMEs: JAIN, LUCKY  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Area;Award;Basic Science;Biomedical Engineering;Biomedical Research;career;career development;Child Health;Child health care;Childhood;curriculum development;Discipline;Educational Curriculum;Environment;experience;Extramural Activities;Faculty;Fellowship;Fellowship Program;Foundations;Funding;Generations;Goals;Grant;Health Benefit;interdisciplinary approach;Joints;Laboratory Research;meetings;Mentors;Mentorship;next generation;pediatric department;pediatrician scientist;Physicians;programs;prospective;Publications;recruit;Research;Research Infrastructure;Research Personnel;Resources;Scholars Program;Scientist;Structure;Supervision;System;Teacher Professional Development;Technology;Training;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Atlanta Pediatric Scholars Program


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Liver Disease;Rare Diseases;Social Determinants of Health

PHR: PROJECT NARRATIVE Fasciola hepatica causes a zoonotic infection reported from 81 countries around the world associated with anemia, stunted growth, and liver disease. Despite being targeted as a neglected tropical disease by WHO very little progress has been made in control, diagnosis, and surveillance. We propose using a comprehensive one-health approach to disentangle human transmission studying the spatial temporal associations between multiple hosts and environmental conditions considering factors affecting control such as lack of diagnostics and surveillance tools, drug efficacy, and infection susceptibility.

PI_NAMEs: CABADA, MIGUEL MAURICIO (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: adaptive immune response;Address;Affect;Africa;Aftercare;Agriculture;Anemia;Animals;Antigens;Area;Asia;Automobile Driving;Biological Factors;burden of illness;Cells;chemotherapy;Child;Chronic;chronic infection;cohort;Collaborations;Communicable Diseases;Communities;Complex;Country;Data;Developing Countries;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Diagnostic tests;Disease;DNA;drug efficacy;Drug resistance;Economics;Effectiveness;efficacy evaluation;Environment;Environmental Risk Factor;enzootic;Epidemiologic Factors;Epidemiology;experience;Fasciola;Fasciola hepatica;Fascioliasis;food insecurity;Fostering;Geographic Information Systems;Goals;Growth;Habitats;Health;Helminths;Hematopoietic;Hepatica;high resolution imaging;Human;Human Resources;Image;Immune;Immunologic Memory;Immunology;In Vitro;Incidence;Infection;infection burden;infection risk;Inflammatory Response;Innate Immune Response;insight;Intervention;land use;Life Cycle Stages;Liver diseases;Livestock;Macrophage;Malnutrition;Methods;Middle East;Modeling;Molecular;multidisciplinary;Mus;neglected tropical diseases;novel;Parasite Control;Parasites;Parasitology;Peru;Peruvian;Pharmaceutical Preparations;Polymerase;Poverty;predicting response;Predisposition;Prevalence;preventive intervention;Production;Prospective cohort;Public Health;recombinase;Recommendation;Reporting;Research;Research Personnel;Resolution;Resource-limited setting;Resources;response;Risk;Ruminants;Rural Community;Sampling Studies;School-Age Population;Site;Snails;South America;Southeastern Asia;Specimen;Statistical Data Interpretation;Statistical Models;stem;surveillance strategy;T cell response;Testing;Time;tool;Training;transmission process;Treatment Effectiveness;Treatment Efficacy;Treatment Failure;treatment response;Trematode Infections;Tropical Medicine;vaccine response;Weather;Zoonoses

PROJECT_TITLE: One-Health Approach to Study Human Fasciola hepatica Transmission and Inform Strategic Control