NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Hematology;Infectious Diseases;Microbiome;Sepsis

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Candida species, including the multidrug-resistant C. auris and C. glabrata, are opportunistic fungal pathogens that cause severe, life-threatening bloodstream infections (candidemia) in critically ill patients. While Candida gut colonization is a key step in the development of candidemia, there has been little research on how clinical risk factors and host immune pathology contribute to gut colonization. By examining clinical, immune, and Candida genomic determinants that predispose to colonization (including with C. auris and glabrata), this project will provide key insights to allow for eventual development of personalized treatment strategies to avert Candida colonization and infection in vulnerable patients.

PI_NAMEs: ADELMAN, MAX WIENER (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acceleration;Adult;adverse outcome;Affect;Antibiotics;Award;Bacterial Infections;Biological Assay;Blood Circulation;Candida;Candida albicans;Candida auris;Candida glabrata;candidemia;career;Catheters;Characteristics;Chromosome Mapping;Clinical;Clinical Research;clinical risk;cohort;Communicable Diseases;Comparative Genomic Analysis;Coupled;Critical Care;Critical Illness;cytokine;Data;Data Analyses;Data Collection;Data Science;Dedications;Defect;design;Development;Doctor of Philosophy;Ensure;Funding;Fungal Drug Resistance;gastrointestinal;Genetic;Genetic Determinism;Genetic Variation;genome sequencing;genomic epidemiology;Genomics;Goals;gut colonization;high risk;Hospitals;Hybrids;Immune;Immune response;Immunity;Immunologic Factors;Impairment;improved;Infection;insight;Institution;Intensive Care Units;Interferons;Intestines;Invaded;K-Series Research Career Programs;Life;Link;Logistic Regressions;Medical center;Mentors;Mentorship;Methodist Church;microbial genomics;Minority;Modeling;Morbidity - disease rate;mortality;Multi-Drug Resistance;novel;Outcome;pathogen;Pathogenesis;pathogenic fungus;Pathology;Patient Care;patient oriented research;Patient-Focused Outcomes;Patients;personalized medicine;Phenotype;Physicians;Plasma;Population;Predisposing Factor;Predisposition;Prevalence;Production;Research;resistance gene;Resistant candida;response;Risk Factors;sample collection;Scientist;Sepsis;Site;Skin colonization;stool sample;T cell response;T-Lymphocyte;Testing;Texas;Training;trait;Translational Research;treatment strategy;trend;United States National Institutes of Health;urgent and serious threat;Venous;whole genome

PROJECT_TITLE: Pathogen and patient determinants of Candida gut colonization in critically ill patients

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: OD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Women's Health Research

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE Thanks to advances in genome editing technologies, it is possible to generate nonhuman primates (NHPs) with precise germline genomic alterations, enabling researchers to generate highly refined models of human disease; however, the time and cost associated with existing technologies limits the availability of these NHPs. Here we propose an innovative technology to aid in the rapid and cost effective generation of transgenic NHPs for research. This resource will significantly benefit science across multiple disciplines, and pave the way for additional technologies to improve transgenic NHP research.

PI_NAMEs: BIMBER, BENJAMIN  (contact);BURWITZ, BENJAMIN J

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acceleration;Animals;Base Sequence;Biological Assay;Birth;blastocyst;Cell Culture Techniques;cell type;Cells;Consumption;cost;cost effective;Data;Development;Discipline;DNA;DNA Integration;DNA Sequence Alteration;Docking;Embryo;Embryo Transfer;Ensure;Expenditure;Female;Fertilization in Vitro;Future;Future Generations;Gene Delivery;Generations;Genes;Genetic;Genetic Materials;Genetic Recombination;Genetic Transcription;genome editing;Genomics;Germ Cells;Germ Lines;Goals;Human;human disease;human model;improved;In Vitro;Industry;Infant;innovative technologies;integration site;Investments;Knock-in;Lentivirus;Macaca;Macaca mulatta;Mediating;Methods;Microinjections;Modeling;Molecular;new technology;nonhuman primate;novel;Oocytes;Oregon;Ovarian Stimulations;Primates;progenitor;Publishing;Rapid screening;recombinase;repaired;Reporter;Reporting;Research;Research Personnel;Resources;Rodent;Rodent Model;Science;screening;Signal Transduction;Site;System;Technology;Time;Tissues;tool;Transfection;Transgenes;Transgenic Model;Transgenic Organisms;Transposase;United States National Institutes of Health;Validation;vector;zygote

PROJECT_TITLE: Rapid Generation of Transgenic Rhesus Macaques using a Safe-harbor Genomic Docking Site

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases;Women's Health Research

ORG_CITY: DALLAS

ORG_DEPT: SURGERY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Pancreatic ductal adenocarcinoma (PDA), a lethal cancer is characterized by frequent metastasis, immune evasion and therapy resistance. We have recently demonstrated that pleiotrophin (PTN) is a metastasis-associated protein in breast cancer and that inhibiting PTN reduces metastasis in manner dependent on the adaptive immune system. PTN has also been linked to PDA progression. Here we propose to test the efficacy of PTN inhibition in the context of PDA.

PI_NAMEs: BREKKEN, ROLF A (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Ablation;Adaptive Immune System;Address;Area;Biological Products;Breast Cancer Model;Breast Cancer Patient;cancer cell;Cancer Etiology;cancer type;Cessation of life;chemotherapy;Clinical;combat;Combined Modality Therapy;cytokine;Data;Development;Disease;Disease Progression;Drug resistance;Effectiveness;efficacy testing;Embryo;Evaluation;Event;Excision;Foundations;Genetic;Genetically Engineered Mouse;Goals;Heparin Binding;Immune;immune checkpoint blockade;Immune Evasion;immunoregulation;Immunotherapy;improved;insight;Invaded;Link;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammary Gland Parenchyma;member;Metastasis-associated protein;Metastatic breast cancer;Metastatic Neoplasm to Lymph Nodes;Metastatic Neoplasm to the Lung;midkine;Molecular;Molecular Target;mouse model;Mus;Neoplasm Metastasis;neurotrophic factor;New Agents;new therapeutic target;novel;novel strategies;Operative Surgical Procedures;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patients;pharmacologic;pleiotrophin;pre-clinical;Pre-Clinical Model;preclinical evaluation;Protein Family;research clinical testing;Resistance;response;single-cell RNA sequencing;Solid;Squamous cell carcinoma;standard of care;stem-like cell;success;Survival Rate;Systemic Therapy;targeted agent;targeted treatment;Testing;Therapeutic;therapeutically effective;therapy development;therapy resistant;tool;treatment response;treatment strategy;tumor microenvironment;tumor-immune system interactions;United States;Work

PROJECT_TITLE: Inhibition of pleiotrophin to combat pancreatic cancer metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-8 (M1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Pediatric;Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE  The overarching goal of our research is to determine the causes and elucidate the mechanisms of early onset colorectal cancer (EOCRC). In this proposal we will test the hypothesis that early life exposure to commonly used antibiotics will alter the gut microbiome and inflammatory microenvironment to increase the risk of EOCRC, using preclinical models. The results from these studies will allow us to identify developmental stages of susceptibility to antibiotics, inform the development of novel strategies to identify high risk individuals and interventions to minimize risk of EOCRC, make informed decisions on how to mitigate the deleterious effects of antibiotics that are indispensable for fighting infections, and provide the foundation for future studies to identify components of human microbiota that mediate increased risk for EOCRC.

PI_NAMEs: PENA, MARIA MARJORETTE (contact)

PROGRAM_OFFICER_NAME: GUNASEKHARAN, VIGNESH KUMAR

PROJECT_TERMS: Adult;Affect;Age;Animals;Antibiotic Resistance;Antibiotics;Bacteria;beta-Lactams;Birth;Cancer Etiology;carcinogenicity;Cessation of life;Child;Childhood;Chronic;Colon;Colorectal;colorectal cancer risk;Conceptions;Development;Dietary Factors;Disease;Distal;Dose;dysbiosis;early life exposure;early onset colorectal cancer;Epidemiology;Epigenetic Process;Event;experimental study;Exposure to;fecal transplantation;fighting;Fostering;Foundations;Future;Gene Expression;genetic signature;Germ-Free;global environment;Goals;gut microbiome;gut microbiota;Health;high risk population;Human;Human Microbiome;human microbiota;Immune;Incidence;Individual;infancy;Infant;Infection;Inflammation;Inflammatory;Intervention;Knowledge;Knowledge acquisition;Life;lifestyle factors;Link;Macrolides;Malignant Neoplasms;Measures;Mediating;Microbe;microbiome;microbiome composition;microbiome signature;microorganism;Modeling;mortality;mouse model;Mus;Mutation;novel;novel strategies;Obesity;Outcome;Patients;Persons;pre-clinical;Pre-Clinical Model;preclinical study;Predisposition;Pregnancy;prepuberty;prevent;Puberty;Public Health;Rectum;Research;Risk;Risk Factors;risk minimization;risk mitigation;Risk Reduction;Role;sedentary lifestyle;Testing;Time;tumor;young adult

PROJECT_TITLE: The Role of Early Life Exposure to Antibiotics on Risk of Early Onset Colorectal Cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Detection of pancreatic cancer at early stages (when curable treatments are effective) could represent an effective strategy to improve the survival rate of pancreatic cancer. Our prior studies have established blood- based proteomic assays that showed high accuracy in detecting pancreatic cancer from healthy and benign disease controls in multiple independent cohorts. The current proposal will carry out analytical and clinical validations of the proteomic assays, which could be potentially deployed for clinical utilities if successfully validated.

PI_NAMEs: CHEN, RU  (contact);PAN, SHENG

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: Antibodies;Benchmarking;Benign;Biological;Biological Assay;Biological Markers;biomarker development;biomarker panel;Blood;Blood Tests;CA-19-9 Antigen;cancer biomarkers;Cancer Detection;candidate marker;case control;Characteristics;Cholesterol Homeostasis;Clinical;clinical biomarkers;clinical diagnosis;cohort;Cohort Studies;Collaborations;college;complement system;Detection;Development;Diagnosis;Diagnostic;Discipline;Disease;disorder control;Early Detection Research Network;Early Diagnosis;effective therapy;efficacy evaluation;efficacy testing;experimental study;Guidelines;Health Sciences;high risk population;Immune response;improved;Inflammation;instrument;interest;Lipids;Logistic Regressions;machine learning algorithm;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Medical center;Medicine;Methods;Modeling;Neoplasm Metastasis;neovascularization;operation;Pancreatic cystic neoplasia;Pancreatic Ductal Adenocarcinoma;Pancreatic Intraepithelial Neoplasia;Patients;Performance;Phase;Plasma;pre-clinical;Procedures;Prospective Studies;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;Proteome;Proteomics;Quality Control;Regulation of Proteolysis;Reproducibility;Research Design;response;Sample Size;Sampling;Screening for cancer;Sensitivity and Specificity;Source;Statistical Data Interpretation;Survival Rate;Techniques;Technology;Texas;Universities;Validation;Variant

PROJECT_TITLE: BLOOD-BASED PROTEOMIC ASSAY FOR PANCREATIC CANCER DETECTION

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-8 (M2)]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Pediatric;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Patients with Fabry disease experience debilitating chronic pain in addition to episodic pain evoked by heat or exercise, yet there is a dearth of literature examining the mechanisms that contribute to pain in these patients. Sensory neurons in Fabry disease exhibit increased excitability and spontaneous activity. This proposal investigates the regulation of voltage-gated sodium channels contributing to neuronal excitability in Fabry disease and determines the role of elevated neuronal excitability in heat-evoked pian crises in Fabry disease.

PI_NAMEs: ENDERS, JONATHAN DAVID (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Action Potentials;Adolescent;Affect;Afferent Neurons;Alpha-galactosidase;Attention;Automobile Driving;behavior measurement;behavioral sensitization;Biological Assay;Biophysical Process;Biophysics;Cells;Cellular biology;chronic pain;Communities;Data;density;Disease;Electrophysiology (science);enzyme replacement therapy;Exercise;Exhibits;experience;Fabry Disease;Fever;Fiber;Genes;globotriaosylceramide;Glycosphingolipids;Goals;improved;Ion Channel Gating;Knock-out;Learning;Link;Literature;Mechanics;Membrane Potentials;Modeling;Molecular;Mus;Mutation;Neuronal Dysfunction;neuronal excitability;Neurons;Neuropathy;neurotransmission;novel;Pain;pain behavior;Pain Measurement;pain reduction;pain relief;Pain Research;painful neuropathy;patch clamp;Patients;Persistent pain;Pre-Clinical Model;Prevalence;Property;Quality of life;Rattus;Regulation;Rest;Rodent;Rodent Model;Role;Severities;Sodium;Sodium Channel;Spinal Ganglia;Stimulus;Study models;Testing;Therapeutic;therapeutic target;voltage;voltage/patch clamp

PROJECT_TITLE: Mechanisms of Neuronal Excitability and Pain in Fabry Disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-4 Study Section [NST-4]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Telehealth

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: This study aims to identify a cost-effective and scalable strategy for reducing disparities in access to mental health services among the rapidly growing population of homebound older adults. It plans to evaluate a novel digital mental health intervention for depression, supported by lay providers within aging service agencies, and systematically examine the implementation process, pinpointing barriers, facilitators, and conditions for sustainment from multi-stakeholder perspectives. The expected findings aspire to guide the implementation of accessible, scalable, and cost-effective depression care within aging services, a non-specialty sector with unparalleled reach to the target demographic.

PI_NAMEs: XIANG, XIAOLING  (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: access disparities;Address;Adherence;Aging;assessment application;attentional control;Behavioral;Caring;Case Management;Client;clinical effect;Clinical effectiveness;clinical efficacy;clinically significant;Cognitive;Cognitive Therapy;Communities;community setting;compare effectiveness;Consolidated Framework for Implementation Research;Control Groups;cost effective;Cost Effectiveness Analysis;Data;Data Analyses;Dedications;depressive symptoms;design;digital mental health;digital tool;Disadvantaged minority;disparity reduction;effectiveness evaluation;effectiveness-implementation randomized trial;effectiveness-implementation RCT;effectiveness/implementation hybrid;efficacy trial;empowerment;ethnic minority;Exercise;experience;Face;feasibility trial;field study;Friends;Goals;Health;health disparity;Health Professional;health training;High Prevalence;Home;Hospitalization;Impaired cognition;implementation barriers;implementation evaluation;implementation facilitators;implementation process;Improve Access;improved;innovation;Intervention;Intervention Trial;Interview;Knowledge;Low income;Major Depressive Disorder;Measures;Mediating;Mediation;Mental Depression;Mental Health;Mental Health Services;Methods;Michigan;Monitor;Names;Narration;Natural Language Processing;novel;older adult;Participant;Patients;physically handicapped;Population;Premature Mortality;Process;Process Assessment;process evaluation;programs;Provider;psychoeducation;Psychotherapy;Public Health;Questionnaires;racial minority;Randomized;Research;Research Assistant;Research Training;resource guides;self help;service providers;Services;Severities;skill acquisition;socioeconomic disadvantage;Source;stakeholder perspectives;success;suicidal risk;Symptoms;Techniques;Telephone;telephone coaching;Testing;Text;Therapeutic;Training;Training Support;treatment as usual;treatment effect;Update;usability;web platform

PROJECT_TITLE: Community-Embedded, Layperson-Supported Digital Mental Health Intervention for Homebound Older Adults with Depression: A Type 1 Hybrid Effectiveness-Implementation RCT

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Opioid addiction has taken a form of epidemic in the U.S., resulting in a high number of opioid related overdose deaths. While opioid maintenance provides the gold standard treatment for opioid use disorder (OUD), it has been unsuccessful to prevent relapse to short acting opioids and other substances and to keep OUD individuals in treatment for long-term. In this application, we propose that a combined guanfacine and mindfulness therapy as an adjunct to buprenorphine maintenance therapy will improve stress provoked craving and opioid cue provoked craving compared to guanfacine alone or mindfulness alone treatment in OUD individuals, and thus will ultimately reduce relapse to illicit drugs and enhance treatment retention.

PI_NAMEs: FOX, HELEN CECILIA;RAY, SUCHISMITA  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Acute;Adherence;Affective;Agonist;Anxiety;Attenuated;Behavior Therapy;Behavioral;behavioral pharmacology;Biological;Brain;Buprenorphine;Cells;craving;Cues;design;dysphoria;emotion dysregulation;emotion regulation;Emotional;Emotions;Epidemic;Exposure to;group intervention;Guanfacine;Guided imagery;Heart Rate;hedonic;Hour;Illicit Drugs;Imagery;improved;Individual;innovation;Intervention;intervention participants;Laboratory Study;Maintenance;Maintenance Therapy;Measures;Mediating;medication-assisted treatment;mindfulness;mindfulness meditation;Mindfulness Training;Moods;negative mood;neural;Neurobiology;neuromechanism;novel;Opiate Addiction;Opioid;opioid epidemic;opioid overdose;opioid therapy;opioid use;opioid use disorder;Outcome Measure;overdose death;Participant;Pharmaceutical Preparations;pharmacologic;Phase;placebo group;Placebos;positive mood;prevent;Process;Randomized;receptor;Recovery;Relapse;relapse prevention;remote visit;Research;restraint;Rewards;Safety;Sampling;Schedule;sex as a biological variable;standard care;Stress;Support Groups;Testing;Urine;Visit;Withdrawal

PROJECT_TITLE: Combined guanfacine and mindfulness meditation as an adjunct to buprenorphine maintenance in OUD

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Pediatric post-cardiac arrest syndrome (PCAS) is a state of complex pathophysiology that includes myocardial dysfunction and systemic and cardiac inflammation, and impaired ventricular function and elevated biomarkers of inflammation are thought to be associated with mortality in small, retrospective studies. Through echocardiography, including advanced ventricular function measures including global longitudinal strain (GLS), and circulating biomarker measurement, this project strives to identify key components of pediatric PCAS and their association with mortality. These measures, in addition to clinical factors, will be used to identify subphenotypes of pediatric PCAS that are associated with outcomes which will be critical in identifying patients at high risk for poor outcomes and thus may provide benefits for targeted therapies in future interventional trials.

PI_NAMEs: GARDNER, MONIQUE-ANNE  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Adult;Adverse effects;Age;Animal Model;Biochemical;Biological Markers;Biometry;Biostatistical Methods;Blood Pressure;Brain Injuries;Cardiovascular system;Caring;Cessation of life;Child;Childhood;circulating biomarkers;Circulation;Clinical;Clinical Data;Cluster Analysis;cohort;Complex;Critical Care;Critically ill children;Data;data reduction;Death Rate;demographics;Disease;Echocardiography;EFRAC;Environment;experience;Functional disorder;Future;Goals;Guidelines;Heart Arrest;Heart Diseases;high risk;Hospital Mortality;Hospitals;Image;Impairment;improved;improved outcome;Individual;individualized medicine;Inflammation;Inflammatory;inflammatory marker;Injury;Interleukin-6;Intervention;Intervention Studies;Intervention Trial;K-Series Research Career Programs;Knowledge;Logistic Regressions;Machine Learning;Measurement;Measures;Mentors;Mentorship;mortality;Myocardial;Myocardial dysfunction;Myocardial Reperfusion Injury;Myocarditis;Nature;Neurological outcome;novel;Observational Study;organ injury;Outcome;Oxygen Consumption;patient oriented;patient response;Patients;Pediatric cardiology;Pediatric Hospitals;Pediatrics;Pennsylvania;Pharmaceutical Preparations;Phenotype;Philadelphia;Physiological;Physiology;population based;Positioning Attribute;prevent;Principal Investigator;Process;prognostic;prospective;Proteins;Reperfusion Injury;Research;Research Infrastructure;Retrospective Studies;Sampling;Scientist;Sepsis;Shortening Fraction;standard measure;Steroids;Study models;study population;Subjects Selections;Syndrome;systemic inflammatory response;targeted treatment;Techniques;Temperature;TNF gene;tocilizumab;Training;trait;trial enrollment;Troponin;United States;Universities;Ventricular Function

PROJECT_TITLE: Assessment of Myocardial Dysfunction and Inflammation after Pediatric Cardiac Arrest

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (MA)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Nutrition;Precision Medicine

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Our contribution in this project is expected to be the identification of gut and tumor tissue microbes and immune cells linked to the Empirical Dietary Inflammatory Pattern (EDIP) that drives malignant progression in colon tissue and underlies poor survival among colorectal cancer patients. Our study includes two major aspects of innovation: 1) Integrating a pipeline of novel sensitive bioinformatics tools (elasticnet and exotic) i) to detect parsimonious, yet highly informative microbial profiles in the gut (stool samples); and ii) to isolate a wide range of microbes typically in low abundance (compared to human immune cells) in the tumor microenvironment; while 2) demonstrating how a specific diet pattern (EDIP) influences gut and tumor tissue microbiota, their interactions with immune cells and the consequent clinical outcomes of these interactions for CRC progression and death. This contribution is relevant to public health because it is expected to provide a solid foundation upon which to design precision medicine-based dietary pattern strategies for mitigating inflammatory dietary pattern-related (high-EDIP) gut and tumor tissue microbial dysbiosis and improving the survival of CRC patients.

PI_NAMEs: TABUNG, FRED KINYUY (contact)

PROGRAM_OFFICER_NAME: KUMAR, AMIT

PROJECT_TERMS: Acceleration;anti-cancer treatment;Bacteria;bioinformatics tool;Biological Markers;Body mass index;burden of illness;cancer diagnosis;Cancer Etiology;cancer recurrence;Cancer Survivor;Cause of Death;Cells;Cessation of life;Characteristics;Clinical;cohort;Colon;colon cancer patients;Colorectal Cancer;colorectal cancer prevention;colorectal cancer progression;Colorectal Neoplasms;Data;Data Pooling;design;Development;Diagnosis;Diet;dietary;Dietary Practices;Disease;dysbiosis;Elasticity;Equilibrium;fighting;follow-up;Food;Foundations;Frequencies;fungus;Fusobacterium nucleatum;Germany;Goals;gut microbes;gut microbiome;health related quality of life;high risk;Human;Immune;improved;Inflammation;Inflammatory;inflammatory marker;innovation;Integration Host Factors;Interleukin-6;Intervention;Knowledge;Link;Malignant - descriptor;Malignant Neoplasms;men;Methods;Microbe;microbial;microbiome;microbiota;Molecular;mortality;novel;novel strategies;Oncology;Operative Surgical Procedures;Outcome;Outcome Study;Patient Recruitments;Patients;Pattern;Plasma;Population;precision medicine;Prospective, cohort study;Public Health;Quality of life;Questionnaires;recruit;Recurrence;Risk;Role;sex;side effect;Solid;Standardization;stool sample;survival outcome;Testing;Time;Tissues;TNF gene;transcriptome sequencing;treatment response;tumor;tumor microbiome;tumor microenvironment;Tumor Tissue;Tumor-Infiltrating Lymphocytes;United States;Utah;Virus;Woman

PROJECT_TITLE: Role of the inflammatory dietary pattern in gut and colon tissue microbiomes and impact on survival outcomes among colorectal cancer patients

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Immunotherapy;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

PHR: NARRATIVE Tuberculosis is the leading cause of death in mankind due to infections, and more than 8 million new cases occur each year with 1.2 million deaths per year. Coinfection with HIV-1 has rendered the control of tuberculosis very difficult, and we have discovered a new method of augmenting host defense so that both M. tuberculosis which causes tuberculosis and HIV-1 which causes AIDS can be controlled using a new class of Sirtuin-based drugs. We propose to develop a new intervention using immunotherapy to simultaneously control HIV-TB coinfections.

PI_NAMEs: ENDSLEY, JANICE J;JAGANNATH, CHINNASWAMY  (contact);YI, GUOHUA

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Acetylation;Acquired Immunodeficiency Syndrome;Affect;Anti-Inflammatory Agents;Anti-viral Agents;antimicrobial;Antimycobacterial Agents;Antitubercular Agents;Attenuated Vaccines;Autophagocytosis;Binding;Biology;Candy;Cause of Death;CD4 Positive T Lymphocytes;Cell Culture Techniques;Cessation of life;Child;co-infection;Communicable Diseases;Curiosities;cytokine;Defense Mechanisms;Drug Combinations;Drug Targeting;Environment;Enzyme Induction;Epigenetic Process;Event;Genes;Goals;Granuloma;Growth;Histone Acetylation;Histone Deacetylase;Histone Deacetylation;HIV;HIV Infections;HIV-1;HIV/TB;Host Defense;Human;human model;humanized mouse;Immune;Immuno-Chemotherapy;immunoregulation;Immunotherapy;Individual;Infection;Infectious Agent;Inflammatory;innovation;Interferon Type II;Interleukin-4;Intervention;Lung infections;Macrophage;Measures;Methods;Modeling;Molecular;Mycobacterium tuberculosis;Myelogenous;NF-kappa B;Nitric Oxide;novel;Organism;p65;pathogen;permissiveness;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Play;Predisposition;promoter;Proteins;pulmonary granuloma;Regulation;Reporting;Role;Shock;SIRT1 gene;Sirtuins;T-Lymphocyte;TNFRSF5 gene;Trans-Activators;transcriptome;translational impact;Tuberculosis;tuberculosis drugs;tuberculosis granuloma;tuberculosis immunity;Tuberculosis Vaccines;Undifferentiated

PROJECT_TITLE: Sirtuin -Dependent Regulation of Tuberculosis and HIV Interactions in Macrophages

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 RCU-A (M1)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Precision Medicine

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: Project Narrative As the prevalence of multidrug-resistant bacteria increases, available antibiotics are no longer effective when used alone. It is critical that we develop effective treatment strategy (combination therapy) for multidrug- resistant infections. Otherwise, we are at risk of returning to the pre-antibiotic era in the not too distant future.

PI_NAMEs: TAM, VINCENT H (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acceleration;Acinetobacter baumannii;Algorithms;Animal Model;Anti-Bacterial Agents;anti-fungal agents;anti-microbial drug;Anti-Retroviral Agents;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Biologic Characteristic;Candida auris;Cessation of life;Clinical;clinical application;clinical investigation;clinically relevant;combat;Combined Antibiotics;Combined Modality Therapy;Complex;computerized data processing;Data;design;Development;Devices;Distant;drug development;Drug resistance;effective therapy;Ensure;experience;Funding;Future;Goals;Gram-Negative Bacteria;Grant;HIV;improved;in vitro Model;Incubated;Infection;innovation;insight;Intuition;Investigational Therapies;Klebsiella pneumoniae;Knowledge;mathematical model;Mathematics;Methods;Microbiology;model building;Modeling;monitoring device;Multi-Drug Resistance;multidisciplinary;Multiple Bacterial Drug Resistance;Neisseria gonorrhoeae;new combination therapies;novel;novel therapeutics;Outcome;pathogen;Patient Care;patient response;Patients;Persons;Positioning Attribute;pre-clinical;precision medicine;predicting response;Prediction of Response to Therapy;predictive modeling;Prevalence;Pseudomonas aeruginosa;Research;Research Personnel;Resistance;resistance mechanism;response;Risk;Selection for Treatments;System;Testing;Time;tool;Treatment outcome;treatment strategy;United States National Institutes of Health;Validation

PROJECT_TITLE: Personalized Antimicrobial Combinations to Combat Resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE: Our prior research and preliminary data have demonstrated that the Gram-positive anaerobic pathogen Clostridioides difficile produces membrane-bound ferrosome organelles as part of its defense strategy against host-imposed iron sequestration; however, the molecular basis of ferrosome formation remains poorly understood. The experiments outlined in this application aim to elucidate the underlying mechanisms of ferrosome biogenesis, define the function of the ferrosome iron minerals within the gut community, and determine the impact of nutrient iron on host-microbe interactions. The findings of this proposal will uncover novel factors critical for C. difficile infection and create a framework for developing effective antimicrobial therapeutics to combat this important infection.

PI_NAMEs: PI, HUALIANG  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Anaerobic Bacteria;Antibiotics;antimicrobial;Binding;Biogenesis;Biological Process;biomineralization;Cell membrane;Clostridium difficile;Co-Immunoprecipitations;combat;Complex;Cytoprotection;Data;Diet;Dietary Intervention;Economic Burden;Energy consumption;enteric infection;Escherichia coli;Exhibits;experimental study;Gastrointestinal tract structure;gene interaction;Genetic;Growth;gut colonization;gut inflammation;gut microbiome;gut microbiota;Homeostasis;host microbiota;host-microbe interactions;Immune response;In Situ;in vivo;Incidence;Infection;inorganic phosphate;insight;intestinal homeostasis;Intoxication;Iron;Iron Overload;iron oxidation;Lipids;live cell imaging;Location;Manuscripts;Maps;Mass Spectrum Analysis;Mediating;member;Membrane;Metals;microbial;Minerals;Modeling;Molecular;Molecular Chaperones;Monitor;mouse model;Nature;novel;Nutrient;Operon;Organelles;Outcome;oxidation;pathogen;Pathogenesis;Phospholipids;Physiological;Play;Postdoctoral Fellow;Process;Property;Proteins;Publications;Recurrence;Reproduction spores;Research;resilience;Role;Severities;Sorting;Source;spatiotemporal;Stress;Structure;System;Testing;Therapeutic;time use;trafficking;transposon sequencing;trend;United States;Vesicle;Virulent;Work;yeast two hybrid system;Yeasts

PROJECT_TITLE: The molecular basis of ferrosome organelle biogenesis and its impact on host-microbe interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-D (M1)]


NIH_SPENDING_CATS: Bioengineering;Cancer;Natural Products

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative. While polyketides continue to play an important clinical role in the treatment of cancer, incomplete understanding of their biosynthesis interferes with material access. This program applies a unique state-trapped approach to differentially isolated protein samples for cryo-electron microscopy that will help us understand how polyketide synthases naturally operate. Through these studies, our team seeks an ultimate goal of enabling practical access to critically needed anti-cancer polyketide therapeutics.

PI_NAMEs: BURKART, MICHAEL D. (contact);EUSTAQUIO, ALESSANDRA S

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TITLE: Enabling a rapid transition from synthase to structure

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-Z (M1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health;Telehealth

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Adaptive interventions seek to provide the right intervention to the right person, thereby maximizing benefits and minimizing waste; however, evidence is needed to inform delivery of adaptive interventions at the social context (versus individual) level. This K23 award will innovate by testing multiple social support interventions (family and peer) and establishing the feasibility and acceptability of the protocol and adaptive interventions for adults with T2D. Moveover, completion of this work will provide a mentored experience to fulfill the principal investigator’s goals to gain expertise developing and optimizing diabetes self-care interventions leveraging social support.

PI_NAMEs: RODDY, MCKENZIE K (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Acceleration;acceptability and feasibility;adaptive intervention;Address;Adult;Behavior;Behavioral;career;Chronic;Chronic Disease;Clinical;clinical care;Clinical Trials;community engagement;Data;Data Reporting;design;diabetes distress;diabetes management;Diabetes Mellitus;diabetes self-management;Disease Management;Educational process of instructing;Elements;Enrollment;Evaluation;evidence base;experience;Family;Family member;family support;Feedback;Focus Groups;Friends;Funding;Future;Goals;Health;Heterogeneity;improved;Individual;innovation;Intervention;Intervention Trial;Interview;Knowledge;Lead;Learning;Literature;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Methods;multiphase optimization strategy;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome Assessment;Participant;Patients;peer;peer support;Personal Satisfaction;personalized approach;Persons;Population;Principal Investigator;Process;Protocols documentation;Randomized;recruit;Reporting;Research;Research Methodology;Research Personnel;Resources;response;responsible research conduct;Self Care;Self Management;Sequential Multiple Assignment Randomized Trial;Series;skills;social;social engagement;Social Environment;social relationships;Social support;success;System;telephone coaching;Testing;Text Messaging;texting support;Time;Training;wasting;Work

PROJECT_TITLE: Optimizing an Adaptive Self-care Support Intervention for Adults with Type 2 Diabetes Leveraging their Social Relationships

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Our objective is to integrate and harmonize 29 randomized controlled trial datasets (N=42,509) of early preventive interventions to examine whether they reduced risk for suicide, suicidal thoughts and behaviors, fatal and nonfatal substance use disorder, opioid use disorder, accidents, and all-cause mortality.

PI_NAMEs: CONNELL, ARIN M;EPSTEIN, MARINA ;MORGAN-LOPEZ, ANTONIO A;MUSCI, RASHELLE JEAN;WILCOX, HOLLY C (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Accidents;Address;Adult;adverse childhood events;Age;Archives;Area;Automobile Driving;Behavior;Behavioral;Cessation of life;Characteristics;checkup examination;Child;Child Rearing;Collaborations;Communities;Complex;Consent;coping;Data;Data Analyses;data archive;data dictionary;data harmonization;Data Set;dating violence;Deposition;Detection;Development;deviant peer;Diagnosis;disadvantaged background;Distal;Documentation;Dose;Drug usage;early childhood;early experience;Early-life trauma;Effectiveness of Interventions;Elements;Emotional;ethnic minority population;Ethnic Population;evidence base;experience;Exposure to;Family;Family Nursing;Feeling suicidal;foster care;Funding;Future;Gender;Geography;Goals;Growth;Heterogeneity;indexing;Individual;interest;Intervention;Life;Link;Measures;Mediator;Methodology;Middle School Student;Minority;Modeling;mortality;multilevel analysis;National Institute of Mental Health;opioid use disorder;Outcome;Overdose;Participant;Population;Preparation;Prevention;Prevention program;Prevention strategy;Prevention trial;Preventive;preventive intervention;Principal Investigator;programs;prospective;racial minority population;racial population;randomized, clinical trials;Randomized, Controlled Trials;reducing suicide;Regulation;Reporting;Research;Resources;response;Rights;Risk;Risk Reduction;Rural;Schools;Sex Orientation;Sexual and Gender Minorities;sexual minority youth;Signal Transduction;social;Social Development;social factors;Social support;socioeconomic disadvantage;Substance Use Disorder;suburb;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Symptoms;System;teacher;Techniques;treatment effect;U-Series Cooperative Agreements;United States;universal prevention;Work;Youth

PROJECT_TITLE: Collaborative to understand impacts of early preventive interventions on suicide and overdose mortality using data harmonization methodology

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-E (05)]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Digestive Diseases;Genetics;Liver Disease;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases;Sleep Research

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Cranial radiotherapy for individuals with brain cancer often results in deleterious effects on the sleep/wake cycle and cognitive function, particularly in the context of childhood and grade II/III brain cancer survivors. This application centers on the circadian (24-hr.) regulation of adenosine metabolism in astrocytes, which can function both as a neuroprotectant and as a key modulator of sleep homeostasis. The purpose of these studies is to understand whether clock modulation of the adenosine modulator, adenosine kinase, can be exploited to improve response to cranial radiotherapy.

PI_NAMEs: ACHARYA, MUNJAL M;MAHAN, KRISTIN ECKEL (contact)

PROGRAM_OFFICER_NAME: CLIFFORD, JOHN LEO

PROJECT_TERMS: Adenosine;Adenosine Kinase;adenosine receptor activation;Aftercare;ARNTL gene;Aryl Hydrocarbon Receptor;aryl hydrocarbons;Astrocytes;Astrocytoma;astrogliosis;awake;Basic Science;Behavioral;Binding;Biological Clocks;Brain;Brain region;Cancer Patient;Cancer Survivor;Cancerous;Cell Line;cell type;Cells;Cephalic;Childhood;Childhood Malignant Brain Tumor;circadian;circadian pacemaker;circadian regulation;Clinical;Cognition;Cognitive deficits;cognitive function;common symptom;Complex;conditional knockout;Cre-LoxP;Darkness;experimental study;Feedback;Genes;genetic approach;Genetic Transcription;Growth;Hippocampus;Homeostasis;Hydrocarbons;Immunofluorescence Immunologic;Impaired cognition;improved;In Vitro;in vivo;Individual;Inflammation;Knock-out;Knockout Mice;Light;Liver neoplasms;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Molecular;mouse model;Mus;neuroprotection;Neuroprotective Agents;Normal tissue morphology;Nuclear Receptors;Output;pharmacologic;Play;Primary carcinoma of the liver cells;Process;Proteins;Radiation therapy;receptor;Regulation;response;Role;Signal Pathway;Site;Sleep;Sleep disturbances;sleep regulation;Sleep Wake Cycle;Stratification;suprachiasmatic nucleus;Symptoms;Synapses;Synaptic plasticity;System;Testing;Tissues;Toxic effect;transcription factor;Transgenic Organisms;Translational Research;Translations;tumor;Tumor Suppressor Genes

PROJECT_TITLE: Circadian regulation of astrocytic adenosine kinase in the irradiated and cancer brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (M2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Prevention;Rehabilitation;Women's Health Research

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative  Breast cancer survivors self-report many cognitive deficits, primarily in executive function (planning, problem solving, multitasking), after cancer treatment (i.e. cancer-related cognitive impairments (CRCI). Despite the substantial impact of CRCI, rehabilitation for CRCI is minimal and knowledge to support intervention is lacking. This proposal evaluates if a novel metacognitive strategy training intervention, that targets engagement in activity, is feasible and can improve daily life cognitive performance with associated improvements in activation of neural circuitry underlying executive function.

PI_NAMEs: BOONE, ANNA  (contact);FROELIGER, BRETT ;WOLF, TIMOTHY J.

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: Address;adherence rate;Aftercare;Analysis of Covariance;Attention;attentional control;Automobile Driving;Behavior;Behavioral;behavioral outcome;Behavioral Symptoms;Brain;brain behavior;Breast Cancer Patient;Breast Cancer survivor;Cancer Burden;Cancer Model;cancer rehabilitation;Cancer Survivorship;cancer therapy;cancer-related cognitive impairment;Chronic;Clinical;Cognition;Cognitive;cognitive control;Cognitive deficits;cognitive performance;Collaborations;community involvement;comparison control;Complex;Confidence Intervals;Control Groups;Data;Discipline;Division of Cancer Prevention;Educational Intervention;Educational process of instructing;efficacy testing;evidence based guidelines;Executive Dysfunction;executive function;Fostering;Functional Magnetic Resonance Imaging;Future;Goals;Health;Impaired cognition;Impairment;improved;indexing;Individual;innovation;Intervention;Knowledge;Lateral;Life;Link;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Mediator;Memory;Mission;multitask;neural;neural circuit;neurobiological mechanism;neuroimaging;Neuropsychology;Neurosciences;novel;Occupational;Occupational activity of managing finances;Occupational Therapy;Outcome;Participant;Patient Self-Report;Performance;persistent symptom;pilot test;post intervention;Preparation;Prevalence;Problem Solving;processing speed;programs;Protocols documentation;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Priority;Research Support;Rest;retention rate;Sampling;Series;Single-Blind Study;statistics;symptom management;Task Performances;Testing;Therapeutic;Training;Translational Research;Traumatic Brain Injury;treatment group;Treatment outcome;treatment research;treatment response;Woman;women's treatment;Work

PROJECT_TITLE: Pilot testing of metacognitive strategy training to address cancer-related cognitive impairment in breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (M2)]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Impaired communication between cellular organelles has been claimed as an important disease mechanism in many neurological disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and other. The mechanisms by which alterations at organelle membrane contacts contribute to human neurodegenerative disorders are poorly understood that is largely due to the lack of architecture of multiprotein complexes that physically tether organelle membranes and maintain proper calcium hemostasis essential for neuronal function. The proposed studies will unravel the structural basis of protein- protein interactions involved in establishing and maintaining these membrane contacts, and this knowledge is essential for developing therapeutic inventions for neurodegenerative diseases.

PI_NAMEs: SERYSHEVA, IRINA I (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: 3-Dimensional;Address;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Apoptosis;Architecture;Binding;Biochemical;Biological Process;Brain;Calcium;cancer type;Cell Death;Cell Physiology;Cells;cellular pathology;Cellular Structures;Communication;Communication impairment;Complex;convolutional neural network;Crowding;cryogenics;Cryopreservation;Development;Disease;electron tomography;Electrons;Elements;Endoplasmic Reticulum;Ensure;Environment;extracellular;Extracellular Space;Fluorescent Probes;Foundations;Freezing;genetic regulatory protein;Geography;Goals;Health;Hela Cells;Hemostatic function;Human;Huntington Disease;Hydration status;improved;In Situ;inorganic phosphate;Inositol;insight;Integral Membrane Protein;interest;invention;Ions;ITPR1 gene;Knock-out;Knowledge;light microscopy;Link;Macromolecular Complexes;Mammalian Cell;Measurement;Mediating;Membrane;Metabolism;Methodology;Microscopy;Mitochondria;mitochondrial membrane;Mitochondrial Membrane Protein;Molecular;Multiprotein Complexes;Mus;Mutagenesis;Nervous System Disorder;neural;Neurodegenerative Disorders;Neuromuscular Diseases;Neurons;new therapeutic target;Organelles;Organism;Outer Mitochondrial Membrane;overexpression;Parkinson Disease;Pathologic;Physiological;Physiology;Positioning Attribute;Preparation;Process;programs;protein complex;protein protein interaction;Proteins;receptor;Recombinants;reconstruction;Regulation;Reporting;Research;Resolution;response;Sampling;scaffold;Scanning;Second Messenger Systems;Series;Signal Transduction;Site;spatiotemporal;structural determinants;Structure;System;Techniques;Therapeutic;three dimensional structure;Tomogram;Work

PROJECT_TITLE: Structural basis of ER-mitochondria membrane contacts and neuronal health

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Cryo-based electron microscopy techniques are well established as superior methods for preserving the biological fidelity of cellular processes as well as capturing dynamic molecular events within cells. The Leica EM ICE high-pressure freezer will rapidly vitrify cell and tissue samples for electron microscopy supporting research in the Vanderbilt Brain Institute among 7 NIMH- and NIH-funded laboratories studying the cellular and macromolecular architecture of neuronal processes and synapses. There exists a substantial and fundamental need for this state-of-the-art instrument to support the ongoing work of numerous NIMH- and NIH-sponsored investigators at Vanderbilt University and Vanderbilt University Medical Center.

PI_NAMEs: KRYSTOFIAK, EVAN  (contact)

PROGRAM_OFFICER_NAME: LIU, CHRISTINA HUANG

PROJECT_TERMS: Academic Medical Centers;Alzheimer's Disease;Area;Award;base;Basic Science;Brain;Cells;Cellular biology;cellular imaging;Childhood;Communication;Computers;Contract Services;Core Facility;Electron Microscopy;Equipment;Event;Faculty;Fees;Financial Support;Freeze Fracturing;Freeze Substitution;Freezing;Funding;Glutamate Receptor;Ice;Image;Incubators;Institution;instrument;Interdisciplinary Study;Investigation;Learning;Light;light microscopy;Liquid substance;Medical center;Memory;Mental disorders;Mental Health;Microscopy;Molecular;National Institute of Mental Health;Neurodegenerative Disorders;Neurons;Neurosciences;new technology;Nitrogen;operation;Population;Preparation;pressure;Process;Recording of previous events;Research;Research Institute;Resolution;Resource Sharing;Rett Syndrome;Sampling;Sapphire;Signal Transduction;Synapses;System;Techniques;Tissues;Training;United States National Institutes of Health;Universities;Wages

PROJECT_TITLE: Acquisition of a Leica high pressure freezer for the cryo-based electron microscopy techniques

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-E (03)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_DEPT: PATHOLOGY

PHR: Project Narrative The main objective of this project is to target the MAP2K7 kinase through novel small molecules to support future therapies for children with T-cell acute lymphoblastic leukemia for whom current treatment fails to induce durable remission. We will perform a high-throughput screen to identify novel MAP2K7 inhibitors and evaluate their anti- leukemic properties in pre-clinical mouse models.

PI_NAMEs: LACORAZZA, DANIEL  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acceleration;Acute Lymphocytic Leukemia;Acute T Cell Leukemia;acute T-cell lymphoblastic leukemia cell;Address;Adult;Age;Alternative Therapies;alternative treatment;American Cancer Society;B-Cell Acute Lymphoblastic Leukemia;Binding;Biochemical;Biological Assay;Cancer Etiology;cancer therapy;Cause of Death;Cell Line;Cells;Cessation of life;chemical binding;Chemicals;Chemoresistance;chemotherapy;Child;Childhood Acute Lymphocytic Leukemia;childhood cancer mortality;Childhood Leukemia;Childhood Precursor T Lymphoblastic Leukemia;Classification;Clinic;Clinical;clinical application;clinical translation;Clinical Trials;Collection;college;Colon Carcinoma;cytotoxicity;design;Development;Disease;Disease remission;Disease-Free Survival;DNA;Drops;drug discovery;Drug resistance;Drug toxicity;efficacy evaluation;efficacy study;Epigenetic Process;Exhibits;Future;Genetic;Goals;Hematologic Neoplasms;Hematopoietic Neoplasms;high risk;high throughput screening;Human;improved;Incidence;individualized medicine;inhibitor;Knowledge;Lead;leukemia;leukemia initiating cell;leukemia relapse;Leukemic Cell;Lymphocyte;Malignant Breast Neoplasm;Malignant Neoplasms;MAPK8 gene;Medical;Medicine;mimetics;Mitogen-Activated Protein Kinases;Mitogens;Mixed B- and T-Cell Leukemia;Modeling;Molecular;Molecular Target;mouse model;new therapeutic target;NOTCH1 gene;novel;novel therapeutics;Pathogenesis;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pediatric Hospitals;pediatric patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Physicians;Population;Positioning Attribute;pre-clinical;prevent;Prognosis;Property;Proteins;Publishing;Recurrent disease;Refractory;Refractory Disease;Relapse;relapse risk;Research;Role;Sampling;Scientist;screening;small molecule;small molecule inhibitor;small molecule libraries;Stress;targeted treatment;Testing;Texas;Therapeutic;therapeutic target;tool;Toxic effect;transcription factor;Translating;Treatment Failure;treatment response;treatment risk;United States;Xenograft procedure

PROJECT_TITLE: Discovery of MAP2K7 Inhibitors Through DNA-Encoded Chemical Screens to Treat T-Cell Acute Lymphoblastic Leukemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (M1)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Nanotechnology;Orphan Drug;Prostate Cancer;Rare Diseases;Urologic Diseases

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project narrative The proposed research is relevant to public health because it addresses the critical need for the treatment of advanced prostate cancer, a second leading cause of cancer-related deaths among men in the United States. The project explores the development of novel dendrimer-based targeted nanomedicines for selective and intracellular delivery of high payloads of drugs to prostate cancer cells, increasing their efficacy and reducing side effects. Therefore, this work is relevant to the mission of NIH relating to treating cancer.

PI_NAMEs: SHARMA, ANJALI  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Achievement;Address;advanced prostate cancer;androgen deprivation therapy;androgen independent prostate cancer;Animal Model;Antigen Targeting;Binding;cancer care;cancer clinical trial;Cancer Etiology;Cancer Patient;Castration;Cells;Cessation of life;Chemistry;chemotherapeutic agent;chemotherapy;Clinical;clinical candidate;clinical translation;Clinical Trials;clinically relevant;Combined Modality Therapy;Copper;cyanine dye 5;cytotoxic;cytotoxicity;Dendrimers;design;Development;Disease Resistance;Dose;Drug Delivery Systems;Drug toxicity;Economics;Europe;Exhibits;experience;flexibility;FOLH1 gene;Goals;Human;Hydroxyl Radical;Image;immunogenicity;improved;In Vitro;in vivo;inhibitor;innovation;Label;Ligands;Malignant neoplasm of prostate;Malignant Neoplasms;Membrane;men;Mission;Mus;nano;nanomaterials;nanomedicine;Nanotechnology;nanotechnology platform;nanotherapy;neoplastic cell;neovasculature;novel;Organoids;Outcome;patient derived xenograft model;Patients;Pharmaceutical Preparations;Platinum;Preclinical Testing;Primary carcinoma of the liver cells;Prognosis;prostate cancer cell;prostate cancer model;Prostate Cancer therapy;Public Health;Radiation therapy;Radical Prostatectomy;radioligand;receptor;Recurrence;Renal Cell Carcinoma;Research;side effect;standard of care;Surface;Survival Rate;targeted delivery;taxane;Technology;Therapeutic;Toxic effect;tumor;tumor progression;Tyrosine Kinase Inhibitor;United States;United States National Institutes of Health;uptake;water solubility;Work

PROJECT_TITLE: Targeted nanotherapies for the treatment of prostate cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (M3)]


NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Neurosciences;Women's Health Research

ORG_DEPT: NEUROSURGERY

PHR: Project Narrative The goal of this proposal is to determine the efficacy and mechanism of action of a novel combination therapy for brain metastases of HER2-enriched breast cancer and triple-negative breast cancer. This goal will be reached through using relevant models of breast cancer, including cell line-derived xenograft mouse models and experimental metastases models. If successful, our project will identify a novel therapeutic strategy for patients with breast cancer brain metastases and provide major advances in breast cancer biology and therapy.

PI_NAMEs: LO, HUI-WEN  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: American;angiogenesis;anti-fungal agents;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier penetration;blood-brain barrier permeabilization;Brain;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Prevention;Cancer Biology;cancer diagnosis;cancer stem cell;cancer therapy;Cell Line;Cells;Chemicals;Clinical;Clinical Trials;Combined Modality Therapy;comparison control;data mining;Data Set;Diagnosis;Drug resistance;Drug Targeting;effective therapy;efficacy evaluation;ERBB2 gene;ETV4 gene;FDA approved;gain of function;Genes;Genetic;GLI gene;Goals;Growth;HER2 inhibition;In Vitro;in vivo;Incidence;inhibitor;Injections;Invaded;Ketoconazole;knock-down;Malignant Breast Neoplasm;Malignant neoplasm of thyroid;Malignant Neoplasms;malignant phenotype;Mammary Neoplasms;Mediating;Mediator;Metastatic breast cancer;Metastatic malignant neoplasm to brain;migration;Modeling;mouse model;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;novel therapeutics;overexpression;Pathway interactions;Patients;Penetrance;Pharmaceutical Preparations;Phase 0 Clinical Trial;pre-clinical;preclinical study;Prevention;Primary Neoplasm;Prognosis;Receptor Protein-Tyrosine Kinases;Reporting;Resistance;response;Role;Sampling;stem cell division;synergism;Testing;The Cancer Genome Atlas;Thyroid Gland;Time;Tissues;transcription factor;transcriptome;transcriptome sequencing;Transfection;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;Tumor Tissue;Validation;Variant;Woman;Women's mortality;Xenograft procedure

PROJECT_TITLE: Understanding and overcoming resistance of breast cancer brain metastases to RET inhibition

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (M1)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE Middle to older age Latina immigrants have a higher incidence of cervical cancer than non-Hispanic Whites. The goal of the proposed project is to partner with community research team members to develop a multi-level intervention that builds on the strengths of community health centers, where many underserved and marginalized individuals receive a wide range of preventive services. The results of this project will help community healthcare systems develop scalable interventions for marginalized patients with a particular emphasis on community-clinic partnerships to increase cervical cancer screenings, which do not involve a one-time behavior but rather require ongoing follow-up and monitoring to improve health outcomes.

PI_NAMEs: VASQUEZ GUZMAN, CIRILA ESTELA  (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Address;Affect;Age;Age Years;aged;aging population;Area;Back;Behavior;cancer diagnosis;cancer prevention;Caring;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervix Uteri;Characteristics;Clinic;Clinical;Clinical Research;Clinical Trials;cohort;Collaborations;Colorectal Cancer;Communication;Communities;community clinic;community engaged research;community engagement;Community Health;Community Health Networks;Community Healthcare;community organizations;community partnership;community research;Complex;culturally appropriate intervention;Data;Data Set;Death Rate;design;Detection;Development;Diagnosis;Disparate;Disparity;disparity reduction;Economics;Education;effectiveness testing;Equity;ethnic identity;Ethnic Origin;Ethnic Population;Evaluation;faculty mentor;Focus Groups;follow-up;Funding;Goals;Guidelines;Health;health care disparity;health inequalities;health literacy;Health Services Research;Health system;Healthcare;Healthcare Systems;high risk;human old age (65+);Immigrant;implementation science;improved;Incidence;Individual;Inequity;informant;Infrastructure;Insurance;International;Intervention;intervention mapping;Interview;K-Series Research Career Programs;Knowledge;Latina;Latina Population;Leadership;Lesion;Link;Low income;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant Neoplasms;marginalization;marginalized population;Medical;member;Mentored Research Scientist Development Award;Mentors;Methods;Mexican;middle age;Modeling;Monitor;mortality;multidisciplinary;National Cancer Institute;Neighborhood Health Center;Neighborhoods;Not Hispanic or Latino;novel;older women;Outcome;Pacific Northwest;patient population;Patients;Persons;Play;Policy Developments;Population;Positioning Attribute;prevention service;Preventive service;Primary Care;Provider;Qualitative Research;Race;racial population;Recommendation;reproductive;Research;Research Personnel;Role;safety net;Science;screening;screening services;sexual and reproductive health;Site;skills;social;Social isolation;Social Sciences;sociologist;Structure;success;System;therapy design;Training;Translating;Transportation;tv watching;Underserved Population;Uninsured;United States;Vulnerable Populations;Woman;women's diagnosis

PROJECT_TITLE: Assess and Design a Multi-level Intervention with Middle to Older Age Mexican Immigrants to Increase Cervical Cancer Screening in Community Health Clinics

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative The goal is to understand how social media can be used as tool to promote minority youth mental health and resilience in the context of climate change. We will explore minority youth experiences with climate activism on social media and co-design a climate social media campaign to build capacity and resilience of minority youth.

PI_NAMEs: PARNES, MCKENNA  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Advocacy;Age;Anxiety;Area;Awareness;Behavior;Behavioral;Black race;Case Study;childhood anxiety;children of color;Climate;climate change;climate crisis;climate-related health;clinically significant;Communication;Communications Media;Communities;community based participatory research;Complement;coping;Coping Skills;Data;design;Development;Discrimination;Distress;Educational workshop;Effectiveness;Emotional;Environmental Health;Equity;Ethnography;experience;Exposure to;Fostering;Foundations;Fright;Future Generations;gender minority youth;Goals;Guilt;Health Disparities Research;health disparity;Health Professional;Health Resources;human centered design;Indigenous;Individual;Inequality;Influentials;innovation;insight;intergenerational;Interview;Justice;Knowledge;lens;Mainstreaming;Maps;Media Campaign;Mental Depression;Mental Health;Mental health promotion;Mentors;Methodology;Methods;Minority;minority children;minority health;Movement;National Institute on Minority Health and Health Disparities;Pathway Analysis;Pattern;Perception;Persons;Play;Population;Positioning Attribute;Prevalence;Prevention;Process;promote resilience;Property;protective effect;psychologic;psychological distress;Psychopathology;psychosocial;Race;racial discrimination;recruit;Research;Research Design;Research Methodology;Research Priority;resilience;Risk;Sampling;Self Efficacy;sexual minority youth;skills;social;social culture;Social Environment;social factors;social media;Social Network;socioeconomic disadvantage;Specialist;statistics;Stress;Structure;Testing;theories;tool;Training;Translating;United States National Institutes of Health;uptake;Work;Youth

PROJECT_TITLE: Youth climate activism on social media: Building psychosocial resilience among minority youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (M2)]


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

PHR: Project Narrative While much recent research has focused on identifying the antiviral systems of prokaryotes and how those are conserved in metazoans, most eukaryotes are free-living microbes whose antiviral mechanisms remain a mystery like the amoeba species that are home to the enigmatic Megavirales family. Using an approach that combines in silico prediction, discovery-based metatranscriptomic libraries, classical molecular, biochemical, and cellular techniques, and next generation sequencing, this proposal will identify the antiviral machinery of microbial eukaryotes, specifically Acanthamoeba species. This proposal will yield results that impact our understanding of eukaryotic evolution, identify new strategies of viral defense, and provide fresh tools to exploit for biotechnology and medicine.

PI_NAMEs: JORDAN, TRISTAN XAVIER (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acanthamoeba;Acids;Address;Amoeba genus;antagonist;Anti-viral Response;Apoptosis;arms race;Autoimmune Diseases;Bacteria;Basic Science;Biochemical;biological adaptation to stress;Biology;Biotechnology;cDNA Library;Cell Nucleus;Cells;Collection;Detection;Development;DNA Viruses;Double Stranded DNA Virus;Elements;endosymbiont;Engineering;Environment;Eukaryota;Evolution;Explosion;Family;Future;Genetic;Genetic Engineering;Genome;Goals;Home;Homologous Gene;Horizontal Gene Transfer;Host Defense;Human;Immune;Immunity;Immunology;Impairment;in silico;inhibitor;innovation;Insecta;Investments;Knowledge;Lead;Libraries;Life;markov model;Mediating;Medicine;member;Metagenomics;metatranscriptomics;Methods;Microbe;microbial;microbial host;Molecular;Molecular Biology Techniques;Morbidity - disease rate;mortality;next generation sequencing;novel;Nucleic Acids;Open Reading Frames;Organism;Parasites;pathogen;Pathway interactions;permissiveness;Plants;Play;Postdoctoral Fellow;Predisposition;programs;Prokaryotic Cells;protein structure prediction;Proteins;Qualifying;Quality of life;Research;response;Role;Sampling;screening;Sequence Homology;Shapes;skills;Structure;System;Techniques;Technology;Testing;tool;Training;Transcriptional Regulation;transcriptomics;Validation;Viral;Viral Proteins;virology;Virus;Virus Diseases;Work

PROJECT_TITLE: Antiviral Discovery in Microbial Eukaryotes


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Social Determinants of Health

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Adolescent and young adult cancer survivors (AYACSs) encounter psychosocial challenges that are often not addressed by existing interventions, leading to disparities in their quality of life (QOL). In response, the proposed study aims to develop and evaluate a virtual, group-based expressive writing intervention that takes into account developmental stages and communication preferences of AYACSs to improve their QOL and reduce stress. If successful, this intervention will be ready for widespread expansion, including to underserved communities with limited resources and support.

PI_NAMEs: CHOI, EUNJU  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;Adolescent and Young Adult;Adolescent and young adult cancer patients;Age;Area;Award;Behavior Therapy;Biological Markers;Cancer Control;cancer diagnosis;cancer prevention;Cancer Survivor;career;Clinic;Cognitive;cohesion;Collaborations;Communication;comparison intervention;Control Groups;coping;cost effectiveness;Data;design;Development;Diagnosis;Disparity;disparity reduction;Educational Status;emerging adult;Emotional;Employment;experience;expressive writing;Face;Family Planning;flexibility;Future;Goals;Grant;Group Structure;Health;health disparity;Humanities;Hydrocortisone;Impairment;improved;Individual;innovation;Institution;Intervention;intervention effect;Interview;Life;Malignant Neoplasms;Marriage;Mediation;member;Mentors;Mentorship;novel;older adult;Oncology Nurse;Outcome;Participant;Patient Self-Report;peer;Peer Group;perceived stress;Phase;Population;Posttraumatic growth;preference;primary outcome;Privatization;Provider;psychologic;psychosocial;Psychosocial Assessment and Care;Psychosocial Influences;Published Comment;Quality of life;Randomized;Reaction;recruit;Research;Research Methodology;Resources;response;Salivary;Scientist;secondary outcome;Self Administration;Self Efficacy;self-compassion;Services;skills;Social support;Stress;stress reduction;Survivors;symposium;Testing;Thinking;Training;two-arm trial;underserved community;Underserved Population;United States;virtual;Writing;young adult

PROJECT_TITLE: A Virtual, Group-Based, Expressive Writing Intervention for Survivors of Adolescent and Young Adult Cancer

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Immunotherapy;Nutrition;Pancreatic Cancer;Rare Diseases

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Pancreatic cancer is a difficult-to-treat cancer associated with several undesirable features, including uncontrolled nutrient consumption, high invasiveness, therapeutic resistance, dense fibroinflammatory microenvironment, and low patient survival rate. In this proposal, we will focus on glutathione (GSH), which pancreatic cancer cells use to survive. Our goal is to determine how pancreatic cancer cells acquire and use GSH, assess the role of tumor-associated macrophages as a GSH source, and determine how preventing pancreatic cancer from using GSH could help to improve therapeutic outcome.

PI_NAMEs: NWOSU, ZERIBE CHIKE (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: amino acid metabolism;Amino Acids;Antioxidants;Arginine;Automobile Driving;Bioinformatics;Biological Assay;cancer cell;Cancer Etiology;Cell Culture Techniques;Cell Line;Cell surface;Cells;Cessation of life;chemotherapy;Coculture Techniques;Colorectal Cancer;Consumption;Coupled;CRISPR/Cas technology;Cysteine;Cytometry;Data;Data Set;Dependence;deprivation;dietary;Epigenetic Process;epigenetic regulation;epigenomics;experimental study;extracellular;Fibroblasts;Flow Cytometry;Future;G6PD gene;Gene Expression;Gene Expression Regulation;Genes;Genetic;Glutamates;Glutathione;glutathione peroxidase;glutathione synthase;glutathione transporter;Glycine;Goals;Growth;HDAC1 gene;Immunohistochemistry;Immunotherapy;improved;In Vitro;in vivo;Infiltration;inhibitor;inorganic phosphate;insight;knockout gene;KRAS oncogenesis;Macrophage;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Mentorship;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Molecular;mouse model;Nutrient;Nutrient availability;Nutritional Requirements;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;Pancreatic Ductal Carcinoma;Pathway interactions;Patients;Pentosephosphate Pathway;Persons;pharmacologic;Phase;prevent;promoter;Regulation;Research;Resistance;response;Role;Sampling;skills;Skin Cancer;small hairpin RNA;Small Interfering RNA;Sorting;Source;stable isotope;Starvation;Stress;survival outcome;Survival Rate;synergism;targeted treatment;Techniques;Testing;therapy outcome;therapy resistant;Training;transcriptome sequencing;tumor;tumor growth;tumor immunology;tumor metabolism;tumor microenvironment;Tumor-associated macrophages;United States;Vascular blood supply;Withdrawal

PROJECT_TITLE: Disrupting glutathione dependency in pancreatic cancer


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative The vesicular monoamine transporter 2 (VMAT2) is essential for loading neurotransmitters such as dopamine, serotonin and norepinephrine into synaptic vesicles before their release into the synapse. Amphetamine has been shown to alter VMAT2 function, causing release of neurotransmitters from synaptic vesicles. In this proposal, we aim to study the structure and function of VMAT2 and the differences that occur as a result of amphetamine in order to generate new therapies to treat neuropsychiatric disorders and amphetamine abuse.

PI_NAMEs: DALTON, MICHAEL PAUL (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Affinity;Amphetamine Abuse;Amphetamines;antiporter;Architecture;autism spectrum disorder;Binding;Binding Sites;Biochemical;Central Nervous System;Clinical;Complex;Consumption;Cryoelectron Microscopy;Cytosol;Development;Disease;Dopamine;Drug abuse;Drug Addiction;drug development;drug of abuse;Emotions;Epitopes;experimental study;Gilles de la Tourette syndrome;Histamine;Homeostasis;Human;Huntington Disease;Hypertension;Immunoglobulin Fragments;improved;inhibitor;insight;Intervention;Kinetics;Knowledge;member;Membrane Transport Proteins;Mental Depression;Methods;Modeling;Molecular;Molecular Conformation;monoamine;Movement;nanobodies;Nervous System Disorder;neuropsychiatric disorder;neurotransmission;neurotransmitter release;neurotransmitter transport;Neurotransmitters;Norepinephrine;novel;novel therapeutics;Parkinson Disease;particle;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Physiology;Play;presynaptic neurons;Process;Protein Family;Proteins;Protons;receptor;Reserpine;response;Role;Serotonin;side effect;Signal Transduction;Specificity;Structure;Synapses;Synaptic Transmission;Synaptic Vesicles;targeted treatment;Techniques;Technology;Tetrabenazine;tool development;vacuolar H+-ATPase;Vesicle;vesicular monoamine transporter 2

PROJECT_TITLE: Molecular Mechanisms of VMAT2 Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Calcific Aortic Valve Disease (CAVD) is a significant clinical burden that can only be treated via surgical repair or replacement. Our aim for this proposal is to elucidate the molecular mechanisms behind the rapid extracellular matrix dysregulation and calcification deposition leading to valvular thickening and heart failure in human CAVD samples via multi-omic approaches with the hope of identifying pharmacotherapeutic targets. We aim to change the paradigm of treatment from “watch-and-wait” surgical replacement to biomarker identification and early intervention with antifibrotics and anticalcific treatment targeted to specific modifications of histone subtyes, to halt disease progression.

PI_NAMEs: CLIFT, CASSANDRA LUCILLE (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 3-Dimensional;Acetylation;Adult;Advisory Committees;Affect;Age;aging related disease;Amino Acids;aortic valve;aortic valve disorder;Aortic Valve Stenosis;biobank;Biology;biomarker identification;bioprinting;Blood flow;calcification;Carbohydrates;Cardiovascular system;Cell Differentiation process;Cell Separation;Cells;ChIP-seq;chromatin immunoprecipitation;Chromatography;Clinical;clinically significant;cohort;Data;Data Set;Dedications;Deposition;Development;Disease;Disease Progression;Early Intervention;Enzymes;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Extracellular Matrix;Extracellular Matrix Proteins;extracellular vesicles;Functional disorder;Genetic;Genetic Transcription;Genome;glycosylation;Health;Heart failure;Heritability;Histone Code;histone modification;Histones;Human;Hydrogels;Image;Immunofluorescence Microscopy;In Vitro;in vitro Model;inhibitor;inorganic phosphate;insight;interstitial cell;Investigation;laser capture microdissection;Left Ventricular Hypertrophy;Link;Lipids;Malignant Neoplasms;Maps;Mass Chromatography;Mass Spectrum Analysis;Mediating;Mentorship;Methylation;Modeling;Modification;Molecular;multimodality;Multiomic Data;multiple omics;novel;Operative Surgical Procedures;osteogenic;Pathologic;Patients;Persons;Pharmaceutical Preparations;Phosphoric Acid Esters;Phosphorylation;Play;Population;Post-Translational Protein Processing;prevent;Process;Protein Glycosylation;Proteins;Proteome;Proteomics;Publications;Reading;Regulation;repaired;Research;Resolution;Role;Sampling;sex;Signal Transduction;Site;Specificity;Systems Biology;tandem mass spectrometry;Techniques;Tissues;Transcriptional Regulation;Translational Regulation;Vesicle;Writing

PROJECT_TITLE: Defining Epigenetic Regulation of Translational and Post-Translational Modification Signaling in Aortic Valve Stenosis via Multi-Omics Approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-N (M2)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Cell-free DNA (cfDNA) tests can detect diseases like cancer earlier and with just a blood draw, but current tests have low sensitivity for detecting microscopic levels of disease in the body. If we can recover from cfDNA from patient samples, we could significantly boost the sensitivity of current cfDNA tests. This proposal will pursue a novel way to achieve this through engineering of novel antibodies that can protect and improve of the recovery of cfDNA in the body.

PI_NAMEs: TABRIZI, SHERVIN  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Address;Affinity;Antibodies;Appearance;Award;Binding;Biological Assay;Biological Markers;biomarker development;Biomedical Engineering;bisulfite sequencing;Blood;Blood specimen;burden of illness;cancer diagnosis;cancer genome;career development;cell free DNA;Cellular biology;circulating biomarkers;Circulation;Clinic;Clinical;clinical translation;Communicable Diseases;cost;CpG Islands;Custom;Cytoprotection;Data;design;Detection;Detection of Minimal Residual Disease;detection sensitivity;Development Plans;Diagnostic;Disease;DNA;DNA Binding;DNA Binding Agent;DNA Methylation;Drug Kinetics;ds-DNA;Engineering;epigenetic marker;Epigenetic Process;Fc Receptor;General Hospitals;genome sequencing;Goals;Healthcare;Human;Hypermethylation;Image;improved;in vivo;in vivo evaluation;Institution;Kinetics;Knowledge;Leadership;liquid biopsy;Love;Malignant Neoplasms;Massachusetts;Medicine;Mentors;Methods;Methylation;Microscopic;Modification;Monoclonal Antibodies;mouse model;Mus;Mutation;neonatal Fc receptor;New Agents;next generation sequencing;Normal Cell;novel;novel strategies;Nucleic Acids;Oncology;Patients;Performance;Physicians;Plasma;Postdoctoral Fellow;Productivity;Radiation Oncologist;Recovery;Research;Research Personnel;Residual Neoplasm;resistance mutation;sample collection;Sampling;Scientist;screening;Screening for cancer;skill acquisition;skills;Somatic Mutation;Specificity;targeted agent;targeted treatment;Technology;Testing;Time;tool;Training;translational impact;translational potential;tumor;tumor DNA;whole genome;Work

PROJECT_TITLE: In vivo enrichment of cell-free DNA to boost sensitivity of circulating nucleic-acid based diagnostics

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-E (M1)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: TEMPE

ORG_NAME: BMSEED, LLC

ORG_STATE: AZ

PHR: Project Narrative Alzheimer’s Disease and related dementias are a large and growing health problem that currently affects 5.8 million Americans. Despite numerous clinical trials, there is no treatment that stops or reverses the disease progression. This work aims to develop an efficient and physiologically relevant pre-clinical drug screening model for Alzheimer’s Disease with the ultimate goal to develop effective treatments.

PI_NAMEs: GRAUDEJUS, OLIVER  (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: 3-Dimensional;3xTg-AD mouse;Accounting;Affect;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;American;Animal Sources;Astrocytes;Biochemical;bioelectricity;Biological Markers;Biomechanics;Brain;Cell Survival;cell type;Cells;clinical translation;Clinical Trials;Coculture Techniques;commercialization;cost;Dementia;density;Development;Disease;Disease Progression;drug efficacy;Drug Screening;drug testing;effective therapy;efficacy evaluation;electric impedance;Electrodes;Electrophysiology (science);Environment;Epidemiology;Equipment;Evaluation;experimental study;facsimile;FDA approved;Gene Modified;Genetic;Genetic Predisposition to Disease;Genetically Modified Animals;Goals;Health;high throughput screening;Human;human induced pluripotent stem cells;Impaired cognition;improved;In Vitro;in vivo;induced pluripotent stem cell;Injury;innovation;Life;Link;Measurement;Mediating;Methodology;Microelectrodes;Microfluidic Microchips;Microfluidics;Microglia;model building;Modeling;Morphologic artifacts;Mus;nerve stem cell;Neurodegenerative Disorders;neuroinflammation;Neuronal Injury;Neurons;neuroprotection;Noise;novel;Nutrient;Outcome;Oxygen;parallel processing;Parkinson Disease;Pathogenesis;Pathology;Patients;Perfusion;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Physiological;Porosity;pre-clinical;Pre-Clinical Model;prevent;Property;Protocols documentation;Reaction;Recording of previous events;Research;response;Role;screening;simulation;strain injury;Stretching;symptom management;Synapses;System;tau Proteins;theories;therapy development;three dimensional cell culture;Traumatic Brain Injury;Validation;Vascular Diseases;Wild Type Mouse;Work

PROJECT_TITLE: A physiologically relevant pre-clinical drug screening platform for Alzheimer's Disease and Traumatic Brain Injury with integrated stretchable microelectrodes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Epilepsy;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEWTON

ORG_NAME: IMMUNOCHEM THERAPEUTICS, LLC

PHR: NARRATIVE Alzheimer’s disease and epilepsy have an age-related association as well as shared disease progression features, including brain inflammation and cognitive impairment. We developed a small molecule experimental therapeutic, MW189, with potential to alter disease progression. This SBIR project will facilitate progression to future first-in-patient clinical trials for MW189 which has exhibited exceptional safety in recently completed first-in-human safety trials.

PI_NAMEs: KEARNEY, JENNIFER A;SHIFRIN, VICTOR  (contact)

PROJECT_TERMS: Address;Affect;age group;age related;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;analog;Animal Model;arm;Attenuated;Biological;Brain;Central Nervous System Diseases;Clinical;clinical development;Clinical Treatment;Clinical Trials;Cognitive deficits;cognitive performance;comorbidity;cytokine;Data;Dementia;dementia risk;Development;Disease;Disease Progression;Dose;dose information;Drug Kinetics;drug production;Elderly;Encephalitis;Epilepsy;Etiology;Exhibits;first-in-human;Frequencies;Functional disorder;Funding;Future;GMP lots;high risk;Impaired cognition;improved;Incidence;Individual;Inflammation;Inflammatory;Injury;Inpatients;Intractable Epilepsy;Investigational Therapies;Link;Modeling;Molecular;Mus;Nervous System Disorder;Nervous System Trauma;Neuroglia;neuroinflammation;Neurons;neurotoxic;non-demented;novel;novel therapeutics;older adult;Oral;Pathologic Processes;Patients;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phase Ib Clinical Trial;phase II trial;Plasma;Population;preclinical efficacy;Preparation;Prevalence;Production;progression risk;Public Health;Recording of previous events;Recurrence;Risk;Risk Factors;Safety;Scheme;Seizures;Severities;Small Business Innovation Research Grant;small molecule;Structure;success;Symptoms;Synapses;Technology Transfer;Therapeutic;therapeutic target;Time;treatment trial;trial readiness

PROJECT_TITLE: Development of a novel anti-neuroinflammatory experimental therapeutic for epilepsy and Alzheimer's risk


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Cognitive ability declines with age, and declines quicker when living with Alzheimer disease or related dementias (AD/ADRD), but a reference for normative cognitive decline without any neurocognitive disorder is currently unknown. This is a major gap in the literature because researchers cannot accurately judge the results of their study outcomes because there is no reference point to determine how much quicker decline is occurring in individuals living with AD/ADRD. This study proposes to fill this gap by identifying a pace of normative cognitive aging, and determining how much faster decline is in individuals living with AD/ADRD.

PI_NAMEs: KUNICKI, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;Adult;Age;age related decline;aged;Aging;aging related;Alzheimer's disease related dementia;Applications Grants;Area;career;child depression;Clinic;Clinical Trials;Cognition;Cognition Disorders;Cognitive;cognitive ability;Cognitive aging;cognitive change;cognitive impairment no dementia;cognitive performance;cognitive testing;cohort;Cohort Effect;Cohort Studies;Data;Dementia;Diagnosis;Education;Enrollment;Ethnic Origin;Floor;follow-up;Future;Growth;Health and Retirement Study;health data;Impaired cognition;Individual;innovation;Intervention;Joints;Knowledge;Learning;Life;Link;Literature;Measurement;Measures;medical specialties;Medicare claim;Methodology;mild cognitive impairment;Modeling;neurocognitive disorder;next generation;normal aging;novel therapeutics;older adult;Outcome Study;Participant;Pathologic;performance tests;Persons;Pharmacologic Substance;Population;practice setting;Prevention;programs;Property;Protocols documentation;Psychometrics;Race;rate of aging;Research;Research Personnel;Research Project Grants;response;sex;sound;Standardization;Survival Analysis;Testing;theories;United States;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health

PROJECT_TITLE: Defining rates of cognitive aging in adults with and without dementia using the CODA cohort

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Health Services;Mental Health;Mental Illness;Schizophrenia;Serious Mental Illness

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: This proposal, submitted in response to NIMH RFA-MH-23-265, Developing Measures to Advance Quality in Mental Health Care Services, aims to develop Person-Centered Outcome measures for assessing quality of goal-directed care for individuals with serious mental illnesses, such as schizophrenia and bipolar disorder, The approach is innovative in combining personalization of goals for individual service users with a method, known as goal-attainment scaling, for tracking progress on goals in a standardized quantitative way that can be used in an outcome measure, Developing these measures will provide an assessment approach, complementary to conventional symptom-based outcome measures, that assesses delivery of person-centered care in the context of long-term recovery-oriented treatment of SMI, filling a gap in behavioral health quality measurement identified in the literature, Project Narrative

PI_NAMEs: BLAUM, CAROLINE S;BRESLAU, JOSHUA A (contact)

PROGRAM_OFFICER_NAME: DAVIS, BESHAUN JAMAAL

PROJECT_TERMS: Accreditation;Achievement;Address;Administrator;Adult;Arizona;behavioral health;Bipolar Disorder;care outcomes;Caring;Certification;Chronic;Clinic;Communities;community based service;community based treatment;Complex;Data;Data Collection;design;Development;Elderly;Evaluation;experience;falls;Goals;Health;health care service;Health Services Research;Healthcare;home based service;implementation measures;improved;Individual;individualized medicine;innovation;Interview;Learning;Literature;long term recovery;Measurement;Measures;Mental Health;Mental Health Services;Methods;National Committee for Quality Assurance;National Institute of Mental Health;older adult;Outcome;Outcome Assessment;Outcome Measure;Patient-Focused Outcomes;payment;Performance;person centered;personalized care;Persons;physical conditioning;Primary Care;Process;programs;Psychometrics;Published Comment;Quality of Care;Reporting;Research;Research Personnel;response;Risk Adjustment;risk stratification;Sampling;Schizophrenia;Schools;Services;severe mental illness;Site Visit;Social Work;Specific qualifier value;Standardization;Symptoms;Testing;Texas;Time;treatment planning;United States Centers for Medicare and Medicaid Services;Universities;usability;Validity and Reliability;Work;working group

PROJECT_TITLE: Measuring What Matters-Patient Centered Outcome Measures of Goal-Directed Care for People with Serious Mental Illness

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (05)]


NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Sleep Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative The complex relationship between sleep and neural plasticity remains a subject of debate. In this project I hypothesize that experience-dependent changes in neuronal circuits undermine optimal information processing, thereby increasing the need for sleep. To support this hypothesis, a machine learning algorithm will be developed to extract the dynamical rules for sleep homeostasis, experimental work will be conducted to test the plasticity thresholds in neural circuits, and a model will be developed to build predictions and test the mathematical limits of such a problem.

PI_NAMEs: FOSQUE, LEANDRO JONATHAN (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Address;Adopted;Animals;Automobile Driving;Behavior;Biological Models;Biophysics;Black Box;Brain;career;Complex;computational neuroscience;Computer Models;control theory;cost;Coupled;Data;Data Set;Derivation procedure;Development;dynamic system;Environment;experience;experimental study;functional plasticity;Homeostasis;indexing;Information Networks;information processing;Investigation;Laboratories;Learning;Machine Learning;machine learning algorithm;machine learning prediction algorithm;mathematical model;Mathematics;Measures;Memory;Mentorship;Methods;Modeling;Modernization;Mus;neural circuit;neural information processing;Neurobiology;neuromechanism;neuronal circuitry;Neuronal Plasticity;Neurons;Neurosciences;optogenetics;Physics;prediction algorithm;predictive modeling;prevent;Price;Process;Property;Research;Runaway;Scientist;Sensory;Sleep;spatiotemporal;Synapses;Synaptic plasticity;Techniques;Testing;theories;Time;Training;transmission process;Work

PROJECT_TITLE: Extracting network-level homeostatic rules for sleep/wake states

STUDY_SECTION_NAME: NST-4 Study Section [NST-4]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Prevention;Social Determinants of Health

ORG_CITY: NEW ROCHELLE

ORG_NAME: SILVERBILLS INC.

PHR: PROJECT NARRATIVE Cybersecurity threats increase every day and, accordingly, cyber-attacks become more sophisticated with time. It is necessary to obtain the highest level of health information compliance. The goal is to use the additional funds to achieve SOC2 Compliance. This, in turn, will continue improve the financial well-being of older LGBTQ+ individuals with cognitive impairment through SilverBills V.3 financial and legal management tool. We will use the funds provided to hire Prescient Assurance and Perfacon to assist us in our efforts to gain the SOC2 certificate. Chris Granzier leads Prescient Assurance and Oleg Puzatkin leads Perfacon and will perform the documentation and asset classification for the certification and liaise with all internal and external stakeholders.

PI_NAMEs: CHESS, ERIC ;LOBEL-ESRIG, MARCI  (contact)

PROGRAM_OFFICER_NAME: PLUDE, DANA JEFFREY

PROJECT_TERMS: Address;Administrative Supplement;Adult;Age;aged;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Award;Budgets;Businesses;Certification;Classification;Collaborations;Computer software;cyber security;Data;Discrimination;Documentation;Economics;Face;federal poverty level;Fostering;Fraud;Fright;Funding;Gender;Gender Identity;gender minority status;Goals;Grant;Health;Health Personnel;Health Status;high standard;human old age (65+);Impaired cognition;improved;Individual;Industry;Intelligence;Lawyers;Legal;Lesbian Gay Bisexual Transgender Queer;Mental Health;Occupational activity of managing finances;older adult;parent grant;Participant;Patients;Personal Satisfaction;Phase;prevent;Prevention;Research Personnel;Risk Management;risk minimization;Savings;Security;Sex Orientation;Sexual and Gender Minorities;Stigmatization;Technical Degree;Technical Expertise;Technology;Time;tool;Trust;United States;Universities

PROJECT_TITLE: SilverBills: A Legal, Technical and Financial Tool for Aging LGBTQ+ Individuals with Impaired Cognition.