ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative This project seeks to test the efficacy of a theory-based mHealth intervention, PositiveLinks (PL) to improve retention in care and viral suppression among people living with HIV. We will adapt PL to an urban cohort of PLWH receiving care in Washington, DC, determine its efficacy compared to the standard of care at 12 months, and conduct mixed methods implementation science research to identify multi-level factors that characterize best practices to implement PL. If successful, this research will lead to the development of a novel and efficacious approach to improving retention in care and viral suppression among PLWH that could contribute to HIV epidemic control.

PI_NAMEs: CASTEL, AMANDA DERRYCK (contact);INGERSOLL, KAREN S

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adult;Android;Appointment;Behavior Therapy;Caring;Case Management;Certification;Cessation of life;Characteristics;Cities;Clinic;Clinical;clinical research site;Cluster randomized trial;cohort;Collaborations;comparative efficacy;Computerized Medical Record;Consent;Consolidated Framework for Implementation Research;Continuity of Patient Care;Data;Development;Diagnosis;dissemination research;Drops;efficacy evaluation;efficacy study;efficacy testing;Enrollment;Epidemic;epidemic response;Feedback;follow-up;Funding;Geography;Goals;Health;health inequalities;HIV;HIV/AIDS;Human immunodeficiency virus test;implementation research;implementation science;improved;Information Resources;innovation;Insurance;Intervention;Laboratories;Learning;Longitudinal cohort study;Measures;medication compliance;Methods;mHealth;mhealth interventions;Monitor;Moods;morphogens;National Institute of Allergy and Infectious Disease;next generation;novel;Outcome;Participant;Patients;Pattern;peer support;Persons;Population;Populations at Risk;pragmatic efficacy trial;Prevalence;primary outcome;Procedures;programs;prospective;Prospective cohort;Prospective Studies;Provider;Public Health;Quality of Care;Randomized;randomized trial;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Methodology;Risk;Risk Factors;Sampling;Secure;Site;smartphone application;social stigma;Social support;sociodemographics;standard of care;Stress;System;Testing;theories;tool;Training;transmission process;treatment as usual;United States Health Resources and Services Administration;United States National Institutes of Health;Universities;Urban Population;usability;Viral;Viral Load result;viral transmission;Virginia;Visit;Washington;web portal

PROJECT_TITLE: Pragmatic Efficacy Trial of mHealth to Improve HIV Outcomes in the DC Cohort

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: TR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PI_NAMEs: ANDERSEN, OLAF S. (contact)

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: Appointment;biopharmaceutical industry;career;Career Choice;Center for Translational Science Activities;Clinic;Clinical;clinical investigation;Clinical Research;Clinical Sciences;Creativeness;Discipline;Education;Educational workshop;Entrepreneurship;Environment;Exposure to;externship;Faculty;Fellowship;Foundations;Goals;graduate student;Industry;Informatics;innovation;Institution;interest;Leadership;Learning;Medical Students;Mentors;National Research Service Awards;Nurses;Operative Surgical Procedures;Postdoctoral Fellow;pre-doctoral;precision medicine;programs;recruit;Research;Resources;sabbatical;Services;skills;Technology;TNFSF15 gene;Training;Training Programs;Translational Research;Underrepresented Populations

PROJECT_TITLE: J. NRSA Training Core


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative: This proposal will expand the capabilities and scope of a new transfer RNA sequencing technology for cancer research in the laboratory and in the clinics. We will apply it to colorectal cancer diagnostics and prognostics, and to biomarker discoveries that help physicians to make improved treatment decisions and patient care.

PI_NAMEs: BISSONNETTE, BRUCE MARC;PAN, TAO  (contact);SHOGAN, BENJAMIN

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Address;aggressive therapy;anti-cancer research;Bacteria;biobank;Biological;Biological Markers;Biological Models;Biology;biomarker discovery;Biopsy Specimen;Blood;Blood specimen;Cancer Biology;cancer biomarkers;cancer care;Cancer Diagnostics;Cancer Etiology;Cancer Patient;cancer recurrence;cancer risk;cancer surgery;cancer therapy;Categories;cell type;Cells;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Clinic;Clinical;clinical application;clinical care;colon cancer patients;Colorectal Cancer;Colorectal Neoplasms;Colorectal Surgery;Complex;Data;Detection;Development;Diagnostic Neoplasm Staging;Dimensions;Disease;DNA;Environment;epigenomics;epitranscriptomics;Essential Genes;Excision;Family;Feasibility Studies;Feces;Formalin;Gene Expression;Genes;Genetic Code;Genomics;Growth;gut bacteria;gut microbes;gut microbiota;high risk;High-Throughput Nucleotide Sequencing;Higher Order Chromatin Structure;host microbiome;host-microbe interactions;Human;human disease;improved;Intestines;Laboratories;Legal patent;lens;liquid biopsy;Malignant - descriptor;Malignant Neoplasms;Manuscripts;Measures;Metadata;Methods;Microbe;microbial;Modification;Morbidity - disease rate;mortality;mouse model;mRNA Translation;Neoplasm Metastasis;new technology;Normal tissue morphology;novel;Operative Surgical Procedures;Pathogenesis;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Performance;Perioperative;Physicians;Physiology;Play;Postoperative Period;precision medicine;prevent;Prognosis;prognostic;Property;Protein Biosynthesis;Proteins;Recurrence;Regulation;Reproducibility;Resources;response;Risk;Risk Assessment;RNA;Role;Sampling;Small RNA;Source;Stimulus;stool sample;Technology;Testing;Therapeutic;Time;tissue fixing;Tissue Sample;Toxic effect;transcriptome;transcriptome sequencing;Transfer RNA;Transfer RNA Aminoacylation;Treatment outcome;tumor;Tumor Biology;Tumor Tissue

PROJECT_TITLE: Transfer RNA sequencing and application to cancer research and clinics


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative How consumers access and utilize retail food outlets could have significant impacts on dietary quality, an important and modifiable behavioral risk factor. At present, methods for the long-term, objective measurement of consumer interaction with the food environment in population research is greatly limited. Using existing geospatial location data from smartphones, we will develop new long-term measures of food retailer use and measure how patterns of food retailing use relates to measures of dietary quality, body weight, and health outcomes.

PI_NAMEs: MONSIVAIS, PABLO  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Acceleration;Address;Adult;Algorithms;American;Behavior;behavior measurement;Behavioral;Big Data;Body Weight;Body Weight Changes;built environment;Cardiovascular Diseases;Cellular Phone;Characteristics;Chronic Disease;Classification;cohort;Communities;Consumption;Cross-Sectional Studies;Data;data space;design;Development;Devices;diaries;Diet;dietary;Dietary intake;Environment;epidemiology study;Error Sources;fast food;Food;Food Access;food consumption;food environment;Food Patterns;Frequencies;Funding;Geographic Locations;Geography;Grant;Health;Health behavior;health data;Health Food;Home;Human;Individual;insight;Location;longitudinal analysis;Malignant Neoplasms;Measurement;Measures;Methods;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;Outcome;Participant;patient engagement;Patient Self-Report;Pattern;Persons;Population;Population Research;Positioning Attribute;Questionnaires;Recording of previous events;Registries;Research;Research Personnel;Resolution;Restaurants;Risk;Risk Factors;Sampling;Services;Shapes;sociodemographics;Source;Surveys;Time;timeline;tool;Travel;Twin Multiple Birth;Unhealthy Diet;United States National Institutes of Health;Washington;Weight;Weight Gain;Work

PROJECT_TITLE: Leveraging cell phone location data to measure interactions with the food environment and associated health outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(54)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Adverse childhood experiences (ACEs) are cumulative childhood exposures to potentially traumatic family and community experiences that can have lasting, negative impact on health, with potential intergenerational transmission of effects. The purpose of this mixed methods study is to understand how parents' exposures to ACEs and positive childhood experiences (PCEs) impact their parenting practices, particularly in the context of living in unsafe neighborhoods. This study will advance the science of ACEs by elucidating protective and health-promoting factors in the intergenerational transmission of ACEs and explore a method of understanding how neighborhoods influence the impact of ACEs and PCEs on parenting practices using community-level geospatial data.

PI_NAMEs: HOPPE, EMILY  (contact)

PROGRAM_OFFICER_NAME: BLACHMAN, DARA

PROJECT_TERMS: 8 year old;Address;Adult;adverse childhood events;Affect;arm;Baltimore;Behavioral;Buffers;Cessation of life;Characteristics;Child;Child Rearing;Child Welfare;Childhood;Cities;Clinical;Communities;community violence;contextual factors;Cross-Sectional Studies;Data;deprivation;design;Dimensions;Emotional;Environment;experience;Exposure to;Family;Family member;Feeling;Goals;Health;health disparity;Health Promotion;Home;Imprisonment;improved;Individual;innovation;intergenerational;Intervention;Interview;Investigation;Low income;Mental Health;Methods;Modeling;multilevel analysis;neglect;neighborhood safety;Neighborhoods;neurobehavioral;Outcome;Parents;Participant;Perception;Persons;Phase;phenomenological models;physical conditioning;Policies;Poverty;prevent;Process;protective effect;protective factors;Psychopathology;psychosocial;Reaction;Recurrence;Reporting;Research;resilience;Resources;response;Role;Safety;Sampling;Schools;Science;social;Source;Strategic Planning;Surveys;Testing;transmission process;Urban Community;urban setting;Violence;violent crime;working group

PROJECT_TITLE: Parents' Adverse and Positive Childhood Experiences and their Parenting Practices in the Context of Neighborhood Safety

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(83)]


ADMINISTERING_IC: HL

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: NASHVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: This Cardiovascular Biology training program at Meharry in collaboration with Vanderbilt will attract talented African-American and other minority students in their developmental stages, increase their awareness of cardiovascular research, and encourage them to pursue NHLBI-mission relevant research career opportunities. This program will train a new generation of minority scientists in cardiovascular and hematologic diseases who will address the national ethnic underrepresentation in biomedical research.

PI_NAMEs: MARTIN, PAMELA M (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TITLE: Research Training in Cardiovascular Biology at Meharry


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Lung;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: TALLAHASSEE

ORG_DEPT: NUTRITION

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Despite several weight loss-independent benefits of exercise, nearly half of Americans with obesity do not exercise due to low time availability and exertional dyspnea – a major barrier to exercise participation. However, emerging data demonstrates that time-efficient (5-minutes daily) high-resistance inspiratory muscle strength training (IMST) improves cardiovascular health in clinical populations. Therefore, we will determine whether IMST reduces blood pressure, improves respiratory muscle function, and reduces exertional dyspnea using a randomized, double-blind, sham-controlled clinical trial among adults with obesity – potentially identifying a novel, safe, and time-efficient lifestyle strategy to mitigate obesity-related cardiovascular and respiratory dysfunction.

PI_NAMEs: WATSO, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Acute;Adherence;Adult;adult obesity;Aerobic Exercise;Affect;American;arm;Attenuated;Biological Markers;Biometry;Blood Pressure;blood pressure reduction;Blood Vessels;Body Weight decreased;Breathing;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular health;Cardiovascular system;career;career development;Chest Wall Mass;Clinical;clinical training;Clinical Trials;Controlled Clinical Trials;cost;Data;Development Plans;Doctor of Philosophy;Double-Blind Method;Dyspnea;Educational workshop;efficacy evaluation;Endocrinologist;Ensure;Environment;Environmental Medicine;Epidemic;Exercise;exercise intensity;exercise training;Exertion;experience;Extramural Activities;Faculty;Fatigue;Functional disorder;Funding;Future;Goals;Grant;Health;high risk;Hour;Human;Hypertension;improved;Inhalation;interest;International;Journals;Laboratories;Leisures;Life Style;Lung;Measures;Medical center;Medicine;meetings;member;Mentors;Metabolic;Morbidity - disease rate;mortality;Motor;multidisciplinary;Muscle;Muscle Fatigue;Muscle function;muscle strength;National Heart, Lung, and Blood Institute;novel;novel strategies;Obesity;Obstructive Sleep Apnea;older adult;Outcome;Physiological;Physiology;Population;Positioning Attribute;Postdoctoral Fellow;pressure;Prevention strategy;Principal Investigator;programs;psychosocial;Public Health;Randomized;Reporting;Research;Research Training;Resistance;Resources;Respiration Disorders;respiratory;Respiratory Muscles;Respiratory physiology;response;Risk;Safety;Secondary to;Secure;skills;strength training;success;Technical Expertise;technical writing;Texas;Time;tool;Training;treatment strategy;United States National Institutes of Health;Universities;Work;Work of Breathing;Writing

PROJECT_TITLE: Time-Efficient Inspiratory Muscle Strength Training as a New Approach to Lower Blood Pressure, Improve Respiratory Function, and Reduce Exertional Dyspnea in Adults with Obesity


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Diabetes;Nutrition;Physical Activity;Prevention

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE The ENICTO Consortium will conduct studies to evaluate the role of exercise and nutrition interventions in improving cancer treatment outcomes. The ENICTO Coordinating Center will enhance and support this research by: leading the development, collection, and analyses of common data across studies; facilitating communication within the Consortium and between the Consortium with external audiences; and providing administrative support for the Consortium.

PI_NAMEs: EVANS, SCOTT  (contact);ROBIEN, KIMBERLY Z

PROGRAM_OFFICER_NAME: MCKOY, TOMMIE W

PROJECT_TERMS: Adolescent;Agreement;Ancillary Study;Bacterial Drug Resistance;Biometry;Body Composition;cancer therapy;Clinical Oncology;Clinical Research;cohort;Collaborations;Collection;Common Data Element;Communication;Communities;comparative effectiveness study;Complications of Diabetes Mellitus;Cost effectiveness research;Data;Data Collection;data management;data platform;Data Reporting;data resource;data sharing;design;Development;diabetes control;Diabetes Mellitus;diabetes prevention program;Diet;Dietary Intervention;dissemination science;Educational Materials;Electronic Mail;Emergency department visit;Ensure;Epidemiology;Evaluation;Exercise;exercise intervention;exercise prescription;experience;Faculty;Failure;flexibility;Goals;Health Sciences;Hospitalization;implementation science;improved;innovation;insulin secretion;Interest Group;Interruption;Intervention;Lead;Leadership;lean body mass;Life;Malignant Neoplasms;Malnutrition;Maternal-Fetal Medicine Units Network;Medical;medical schools;meetings;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Oncology;Outcome;Outcome Study;Patient Outcomes Assessments;Patients;performance site;personalized approach;Physical activity;Pilot Projects;Policies;Procedures;Protocols documentation;Public Health Schools;Publications;Qualifying;Recommendation;Recording of previous events;Reporting;Research;Research Design;Research Personnel;research study;Research Support;Resources;Role;School Nursing;Site;skills;success;System;Training;Treatment outcome;Treatment Protocols;Treatment-Related Cancer;Universities;Washington;web site;Work;working group;Youth

PROJECT_TITLE: ENICTO Consortium Coordinating Center


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Estrogen;Mental Health;Pain Research

ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE:  A large body of evidence has demonstrated that unique immune cell types and molecular mediators differentially contribute to pain pathogenesis in male and females. In this study, we propose to identify new sexually dimorphic drivers of pain using a novel reverse translational screening approach in conjunction with proteomic and transcriptomic technologies. This project is anticipated to identify new cell types and soluble protein mediators that are causally associated with pain and its comorbidities in patients with chronic pain conditions.

PI_NAMEs: DONNELLY, CHRISTOPHER RYAN (contact);SMITH, SHAD BENJAMIN

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Acceleration;Address;Adoptive Transfer;Adult;Algorithms;American;Animals;Anxiety;anxiety symptoms;anxiety-like behavior;Basic Science;Behavioral;Biological;Biological Markers;Biological Response Modifier Therapy;biopsychosocial;Blood specimen;cell type;Cells;Chronic;Chronic Fatigue Syndrome;chronic pain;chronic pain patient;chronic painful condition;Classification;Clinical;Clinical Research;cohort;comorbidity;Coupled;Cryopreservation;Data;data integration;Data Set;depressive symptoms;Development;Diagnosis;Exhibits;experimental study;Fatigue;Feeling suicidal;Female;Fibromyalgia;Functional impairment;Health;High Prevalence;Hypersensitivity;Immune;Impaired cognition;Impaired health;improved;Individual;individual patient;insight;Investigation;Irritable Bowel Syndrome;Link;male;Mediator;Mental Depression;Mental Health;Methods;Migraine;Molecular;Mus;novel;novel diagnostics;novel therapeutics;Outcome;Pain;Pain management;Pain Research;pain sensitivity;pain signal;Pathogenesis;Patient Care;patient prognosis;patient subsets;patient variability;Patients;Peripheral Blood Mononuclear Cell;Personal Satisfaction;personalized approach;Persons;Phenotype;poor health outcome;pre-clinical;Pre-Clinical Model;pre-clinical research;Proteins;Proteomics;psychologic;psychological distress;Reproducibility;Research;research study;screening;Serum;sex;sex as a biological variable;sexual dimorphism;side effect;single-cell RNA sequencing;Sleep Deprivation;Sleep disturbances;statistics;Stimulus;Stratification;symptom cluster;Symptoms;System;Technology;Temporomandibular Joint Disorders;Testing;therapeutic target;tool;transcriptomics;Vulvodynia;women patients;Women's prevalence

PROJECT_TITLE: Sexually dimorphic pain signaling mechanisms


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: MADISON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The overall objective of this proposal is to train graduate students and postdoctoral scientists about the concept of implicit bias, the effects of bias on underrepresented minority students in the biomedical, behavioral and clinical science (BBCS) fields, and the strategies to mitigate the effects of bias on themselves, as well as in their current and future work environments. This training both complements and extends the previously-funded project titled, Breaking the Bias Cycle for Future Scientists: A Workshop to Learn, Experience, and Change (NIH-NIGMS, R25GM114002, 2005-2020). It also leverages a number of other NIH-funded projects to ensure that successful bias-reducing and mentoring models, trainings/workshops, and strategies are applied in different venues and with additional populations (Carnes, 2015, 2017; Kaatz et al., 2017; Sorkness et al., 2017).

PI_NAMEs: PRIBBENOW, CHRISTINE MAIDL (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Address;Behavioral Sciences;Climate;Clinical Sciences;Collaborations;Development;Education;Educational workshop;empowerment;Engineering;experience;faculty mentor;Funding;Future;Graduate Education;graduate student;Grant;implicit bias;innovation;interest;Knowledge;Learning;literacy;Medicine;Mentors;Minority;Modeling;National Institute of General Medical Sciences;Participant;Persons;Play;Population;Positioning Attribute;Postdoctoral Fellow;professional atmosphere;promote resilience;Research;Research Personnel;resilience;science, technology, engineering, mathematics, and medicine;Scientist;skills;symposium;Talents;Training;underrepresented minority student;United States National Academy of Sciences;United States National Institutes of Health;Universities;webinar;Work

PROJECT_TITLE: Fair Play: Bias Literacy and Resiliency Training to Empower the Future Biomedical Workforce


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: PROJECT NARRATIVE The Puerto Rico IDeA Networks of Biomedical Research Excellence (PR-INBRE) will create new opportunities to study health disparities, develop novel treatments for human diseases, and explore fundamental research questions in the thematic focus areas of Bioinformatics, Neuroscience/Behavior, Molecular Medicine/Cancer, Drug Discovery and Development. By enhancing the biomedical research enterprise in Puerto Rico, the PR-INBRE will increase the representation of Hispanics in the national biomedical workforce and expand their contributions to the improvement of human health.

PI_NAMEs: RODRIGUEZ-MEDINA, JOSE R (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: American;Area;base;Behavior;Bioinformatics;bioinformatics resource;Biomedical Research;career;Communication;Competence;Cultural Diversity;Development;Discipline;Doctor of Philosophy;drug development;drug discovery;Economic Development;Economics;editorial;Education;Educational process of instructing;Educational workshop;Environment;ethnic diversity;Ethnic Origin;Evaluation;experience;Faculty;Financial Support;Floods;fundamental research;Funding;Funding Agency;General Population;Goals;Grant;Growth;Health;health disparity;high standard;Hispanic;Hispanic Populations;Hispanic-serving Institution;Human;human disease;Hurricane;improved;Infrastructure;Institution;instrumentation;Interdisciplinary Study;Island;Journals;K-12 student;Laboratories;Lead;local economy;Malignant Neoplasms;Manuscripts;Measures;Medical;Mentors;Methodology;metropolitan;Minority-Serving Institution;Molecular Medicine;Neurosciences;next generation;novel;Outcome;outreach;Paralysed;Peer Review;Persons;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Process;Program Research Project Grants;programs;Publishing;Puerto Rico;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;Research Support;resilience;response;Route;Science;Scientist;Staff Development;Students;teacher;Teacher Professional Development;Technology;Training;Travel;undergraduate research experience;undergraduate student;Universities;Work;Writing

PROJECT_TITLE: Advancing Competitive Biomedical Research in Puerto Rico


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Achievement;Advisory Committees;Annual Reports;archive data;Benchmarking;Biomedical Research;career;career development;Committee Members;data archive;Decision Making;Development;Educational process of instructing;Ensure;Evaluation;Faculty;Funding;Goals;graduate student;Infrastructure;Institution;Instruction;Lead;Leadership;Logistics;Medical;meetings;member;Outcome Measure;Postdoctoral Fellow;Principal Investigator;Process;Program Research Project Grants;programs;Puerto Rico;Recommendation;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Schedule;Science;Side;Structure;Students;Training;Training Activity;Training Programs;undergraduate research experience;undergraduate student;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: VAZQUEZ-QUINONES, LUIS E (contact)

PROJECT_TERMS: Area;Big Data;Bioinformatics;bioinformatics infrastructure;bioinformatics resource;Biology;Biomedical Research;Biometry;Clinical Investigator;Collaborations;collaborative environment;Community of Practice;Computational Biology;computer scientist;Core Facility;cost;Custom;cyber infrastructure;Data Analyses;Data Science;Development;Education;Educational Activities;Environment;experience;Experimental Designs;Faculty;faculty support;Feasibility Studies;Fostering;Funding;Future;Goals;Grant;High Performance Computing;improved;innovation;Institution;Interdisciplinary Study;Knowledge;Lead;mathematical model;Mentors;Metagenomics;metatranscriptomics;Mission;Modeling;multidisciplinary;next generation;Organizational Models;Population;Postdoctoral Fellow;power analysis;Productivity;programs;Puerto Rico;Recommendation;Research;Research Design;Research Personnel;Research Project Grants;Resources;Role;science education;Science, Technology, Engineering and Mathematics Education;Scientist;Services;skills;statistics;Students;Teacher Professional Development;Training;Training and Education;Training Support;Translating;Universities;Vertebral column;virtual;web server

PROJECT_TITLE: Bioinformatics Resources Core (BiRC)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PI_NAMEs: CADILLA, CARMEN LYDIA (contact)

PROJECT_TERMS: Animal Model;Area;Bacteria;Biological Models;Biological Testing;Biomedical Research;Centers of Research Excellence;Collaborations;Communities;Comprehensive Cancer Center;Consultations;Core Facility;Data;Data Analyses;Development;Doctor of Philosophy;Educational workshop;empowerment;Ensure;experience;Experimental Designs;Faculty;Funding;Generations;Genetic;Genomics;Goals;Human;Human Genetics;human genomics;Infrastructure;innovative technologies;Institution;instrumentation;Interdisciplinary Study;International;Lead;Medical;meetings;Mentors;Mentorship;metabolomics;National Institute on Minority Health and Health Disparities;outreach;Postdoctoral Fellow;programs;Proteomics;Puerto Rico;Research;research facility;Research Personnel;Research Project Grants;Resources;Science;Secure;Services;Students;Technology;tissue/cell culture;training opportunity;translational proteomics;undergraduate student;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Centralized Research Instrumentation Core (CRI)


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science

PI_NAMEs: RODRIGUEZ-ORENGO, JOSE F (contact)

PROJECT_TERMS: Academia;Biological Products;Biomedical Research;Biotechnology;Businesses;Career Choice;Centers of Research Excellence;Collaborations;commercialization;Competence;Data Science;Data Scientist;Development;Education;Elements;Entrepreneurship;experience;Faculty;Financial Support;Fostering;Future;Generations;Government;graduate student;Institution;Intellectual Property;Investments;Knowledge;local economy;meetings;Mentors;Mission;novel;Process;programs;Publications;Puerto Rican;Puerto Rico;Research;Research Personnel;Science;Scientist;skills;STEM career;STEM student;Technology;Training;Training and Education;training opportunity;Training Programs;Travel;undergraduate student;Vision

PROJECT_TITLE: Science and Technology Competency and Education Core


PI_NAMEs: DHARMAWARDHANE, SURANGANIE  (contact)

PROJECT_TERMS: Achievement;Advisory Committees;Applications Grants;Area;Award;Behavior;Big Data;Bioinformatics;bioinformatics resource;Biomedical Research;biomedical resource;Biotechnology;career;career development;Cell Nucleus;Centers of Research Excellence;commercialization;Competence;Complement;Core Facility;design;Development;Development Plans;Doctor of Philosophy;drug discovery;Educational process of instructing;Educational workshop;Evaluation;evidence base;experience;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Extramural Activities;Faculty;Feasibility Studies;Financial Support;Fostering;Foundations;Funding;Goals;Grant;Health;Health Benefit;Hispanic-serving Institution;Human;improved;Individual;Infrastructure;innovation;Institution;instrument;instrumentation;Intellectual Property;Interdisciplinary Study;International;Journals;knowledge base;laboratory facility;Lead;Leadership;Malignant Neoplasms;Manuscripts;Measures;meetings;member;Mentors;microbiome analysis;Molecular Medicine;Neurosciences;non-compliance;Outcome;outreach;Peer Review;Pilot Projects;Postdoctoral Fellow;Preparation;Procedures;Process;Productivity;Program Research Project Grants;programs;Protocols documentation;Publications;Puerto Rico;Qualifying;Research;research and development;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Role;Science;Scientist;skills;Solid;Structure;success;symposium;Talents;teaching laboratory;Technology;Training;United States National Institutes of Health;Writing

PROJECT_TITLE: Developmental Research Projects Program (DRPP)


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE – Overall Antibiotic resistance is one of the foremost public health concerns worldwide. This program to combat antibiotic resistance, which has as its goal to develop new approaches to treat antibiotic resistant infections by targeting the bacterial cell envelope, was specifically designed to be responsive to this global threat. A highly productive multidisciplinary team will function collaboratively to capitalize on the many advances it has already made to enable fundamentally new approaches that target this essential structure.

PI_NAMEs: WALKER, SUZANNE  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Anabolism;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;antimicrobial;Area;Bacteria;Bacterial Antibiotic Resistance;beta-Lactams;Biochemical;Biochemistry;Biogenesis;Biological;Biological Assay;Biology;cell envelope;Cell Maintenance;Cell Physiology;Cell Wall;Chemistry;Collaborations;collaborative approach;combat;Combating Antibiotic Resistant Bacteria;Complex;Creativeness;Cytolysis;Data;data sharing;design;Development;drug resistant pathogen;Ensure;Environment;experience;Family;Foundations;Genetic;genetic approach;Genetic Screening;Glycopeptide Antibiotics;Goals;Gram-Negative Bacteria;Growth;Immune;Individual;Infection;innovation;interdisciplinary collaboration;Investigation;Knowledge;Lipids;Macromolecular Complexes;Maintenance;Membrane;membrane assembly;membrane biogenesis;Membrane Proteins;Molecular;Molecular Genetics;mortality;multidisciplinary;Multiprotein Complexes;Natural Products;new therapeutic target;novel;novel strategies;Organism;pathogen;pathogenic bacteria;Pathway interactions;Peptidoglycan;Play;Polymerase;Polymers;Predisposition;Process;Productivity;programs;protein function;Proteins;Public Health;Reagent;reconstitution;Research Personnel;Resistance;resistant strain;response;Role;Scientist;Staphylococcus aureus;Streptococcus pneumoniae;structural biology;Structure;success;synergism;Technology;Teichoic Acids;Testing;Therapeutic;therapeutic target;tool;Training;Translational Research;Translations;Validation

PROJECT_TITLE: Exploiting membrane targets to overcome antibiotic resistance


ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Individual cells generate and harness polarity domains to organize their contents and drive morphogenesis. The proposed research will fill a critical knowledge gap by investigating how dynamic polarity domains are generated to control cell identity at single-cell resolution within complex, developing tissues. Interrogating polarization mechanisms during morphogenesis will provide valuable insight into essential developmental pathways that are also associated with disease states, such as tumorigenesis.

PI_NAMEs: MUROYAMA, ANDREW D (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TITLE: Polarity mechanisms driving complex morphogenesis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: BERNHARDT, THOMAS G (contact)

PROJECT_TERMS: Acinetobacter baumannii;Adopted;Affect;Affinity;Antibiotic Resistance;Antibiotics;Bacteria;beta barrel;Binding;Biochemical;Biochemistry;Bioinformatics;cell envelope;cell killing;Cell membrane;Cell Membrane Permeability;Cell surface;Cell Wall;Cells;Chemosensitization;Clinical;Complex;Cryoelectron Microscopy;Cytoplasm;Development;Disease;Drug Targeting;Educational process of instructing;Enterobacter;Epitopes;Equilibrium;Escherichia coli;ESKAPE pathogens;Exclusion;Genetic;Glycolipids;Gram-Negative Bacteria;Gram-Positive Bacteria;Growth;Homeostasis;Infection;inorganic phosphate;insight;Klebsiella pneumoniae;Learning;Lipid A;Lipids;Lipopolysaccharides;Medical;member;Membrane;membrane assembly;membrane biogenesis;Membrane Lipids;Membrane Proteins;Methods;model organism;Modification;Molecular Conformation;Multi-Drug Resistance;nanobodies;Natural regeneration;New Agents;novel;O Antigens;Organism;pathogen;Pathway interactions;Penetration;Peptide Hydrolases;Peptidoglycan;Permeability;Pharmaceutical Preparations;Phenotype;Phospholipids;Play;Polymers;Polysaccharides;Predisposition;prevent;Process;Protein Family;Proteins;Proteolysis;Pseudomonas aeruginosa;Pump;Reaction;Recycling;Regulation;Resistance;resistance mechanism;Role;screening;Signaling Molecule;Staphylococcus aureus;Structure;Surface;System;Testing;Therapeutic;transposon sequencing;TRAP Complex;United States;uptake;virtual

PROJECT_TITLE: Project 3: Defining and defeating the mechanisms of outer membrane biogenesis in Gram-negative bacteria


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Pediatric;Prevention;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

PHR: PROJECT NARRATIVE Mammary glands continue to develop throughout late puberty and early adulthood when they are sensitive to environmental disrupters that can increase later breast cancer risk. Using a rat model of human breast development and cancer, our transdisciplinary team, comprised of behavioral, endocrine, and breast cancer biologists, will study how increased stress hormone reactivity, resulting from continuous social isolation, disrupts mammary gland development and stem cell differentiation, thereby increasing the risk of breast cancer. We will also determine if normal mammary gland development can be restored and cancer risk reduced by a pharmacological or social intervention that attenuate stress hormone reactivity.

PI_NAMEs: BRADY, MATTHEW J (contact);CONZEN, SUZANNE DANIELA;MCCLINTOCK, MARTHA KENT

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Adipocytes;Adipose tissue;Adult;antagonist;Attenuated;Behavioral;Biology;Breast;Breast Cancer Model;Breast Cancer Prevention;Breast Cancer Risk Factor;Cancer Burden;cancer care;cancer risk;Cells;Characteristics;chemical carcinogen;Chronic;Data;Defect;design;Development;Differentiation and Growth;Duct (organ) structure;Ductal Epithelial Cell;early life exposure;emerging adult;Endocrine Disruptors;Endocrinologist;Environment;environmental intervention;environmental stressor;Epithelium;Event;experimental study;Exposure to;Gene Expression;Genetic Transcription;Glucocorticoid Receptor;Glucocorticoids;Goals;Height;Hormones;Human;human model;Impairment;interdisciplinary collaboration;Intervention;Lead;Life;life span;Life Style;Link;Malignant Breast Neoplasm;malignant endocrine gland neoplasm;Malignant Neoplasms;mammary;Mammary Duct;Mammary gland;mammary gland development;Mammary Neoplasms;Measures;Mediating;Molecular;novel;Pathway interactions;pharmacologic;Phosphorylation;Physical environment;Population;Population Sizes;preservation;prevent;Production;Psychological Stress;Puberty;Radiation;Rattus;Receptor Activation;receptor expression;response;Risk;Risk Factors;Rodent;Rodent Model;Role;Secondary to;social;Social Environment;social interventions;Social isolation;Sprague-Dawley Rats;stem cell biology;stem cell differentiation;stem cell population;stem cells;steroid hormone;Stress;stress reactivity;stressor;Stromal Cells;Structural defect;Testing;Tumor Burden;Woman;xenoestrogen;young adult

PROJECT_TITLE: Effects of chronic pubertal stressors on mammary gland biology and cancer risk

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative  The proposed research is relevant to public health because the methionine metabolism pathway is altered in a number of different diseases including cancer, obesity, neurodegeneration, and aging. By establishing a mechanistic connection between this pathway and downstream methyltransferases, we will be able to provide attractive and “druggable” targets for the development of novel therapies relevant to these diseases. Therefore, the research is relevant to NIGMS’s mission in supporting basic research that increases understanding of biological processes and laying the foundation for advances in disease treatment.

PI_NAMEs: PARKHITKO, ANDREY A (contact)

PROJECT_TERMS: Affect;Aging;Antioxidants;Basic Science;Biological;Biological Process;Cell Physiology;Development;Disease;druggable target;Foundations;Genetic;Global Change;Goals;Health;Human Pathology;in vivo;innovation;Knowledge;Laboratories;Link;Malignant Neoplasms;Mediating;Metabolic Pathway;Methionine;Methionine Metabolism Pathway;methyl group;Methylation;Methyltransferase;Mission;Mitochondria;Modeling;Molecular;National Institute of General Medical Sciences;Nerve Degeneration;novel;novel therapeutics;Obesity;Oxidative Stress;Pathologic;Pathway interactions;Production;prospective;Protein Biosynthesis;Proteomics;Public Health;Reaction;Research;Research Project Grants;Resistance;response;S-Adenosylhomocysteine;S-Adenosylmethionine;Specificity;Starvation;Stress;System;Testing;Tissues;tool;Work

PROJECT_TITLE: Deciphering the crosstalk between methionine metabolism and methyltransferases in health and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

PHR: While the U.S. population of adults age 65 and over is predicted to double from 35 million in 2000 to 70 million by 2030, the number of physicians with training in aging research is declining. In a parallel, the aging population's diversity is increasing while the proportion of physicians from underrepresented or disadvantaged backgrounds entering careers in aging research is insufficient to meet society's needs. A program that stimulates and excites the interest of a cadre of culturally and ethnically diverse medical students to choose careers in aging research is critically needed.

PI_NAMEs: CHRISTMAS, COLLEEN  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Adult;Age;Aging;aging population;aging related;American;Articulation;Behavior;Biometry;career;career development;Clinical;clinical training;design;Elderly;Epidemiology;Ethnic Origin;experience;follow-up;Generations;Geriatrics;Gerontology;human old age (65+);Institute of Medicine (U.S.);Knowledge;lectures;Measures;medical schools;Medical Students;meetings;Mentors;Methods;Minority Groups;National Institute on Aging;Paper;Participant;Peer Review;Physicians;Population;Productivity;programs;Publications;Reporting;Research;research and development;Research Training;responsible research conduct;skills;Societies;student training;Students;summer research;Surveys;Testing;tool;Training;Training Programs;United States National Institutes of Health

PROJECT_TITLE: Medical Student Training in Aging Research (MSTAR) Program


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_DEPT: NEUROSCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Narrative  Fragile X syndrome (FXS) is one of the most common inherited intellectual disabilities (ID) that is caused by transcriptional silencing of the Fmr1 gene and loss of its encoded fragile X messenger ribonucleoprotein (FMRP). This project will investigate how a particular small non-coding RNA, microRNA-128, regulates postnatal astroglial development and also how the selective loss of this microRNA in brain astroglial cells impact typical FXS phenotypes. Results from this project will begin to define specific microRNA that regulates postnatal astroglial development and will reveal astroglia specific mechanisms and targets to modulate FXS disease development, thus will advance our understanding about the role of astroglia in FXS pathogenesis.

PI_NAMEs: YANG, YONGJIE  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Affect;Astrocytes;Attenuated;autism symptoms;Behavioral;behavioral phenotyping;Binding;Binding Sites;Biochemical;Brain;Cells;conditional knockout;Data;Development;Disease;Down-Regulation;Electrophysiology (science);FMR1 gene;Fragile X Syndrome;Funding;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Transcription;Human;Hyperactivity;Hypersensitivity;Image;Impaired cognition;In Vitro;in vivo;Inherited;Injections;Intellectual functioning disability;Length;Mediating;Mediator;memory acquisition;messenger ribonucleoprotein;Messenger RNA;Microglia;MicroRNAs;Molecular;Morphology;mouse genetics;mRNA Transcript Degradation;mRNA Translation;Mus;nerve stem cell;Neurons;neurotransmission;Nucleotides;Oligodendroglia;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;Play;postnatal;postnatal development;Proteome;Regulation;repetitive behavior;response;RNA-Binding Proteins;Role;Seizures;Sensory;Signal Transduction;social;software development;Specific qualifier value;Synapses;synaptic function;synaptogenesis;transcriptome;Translational Regulation;Translations;Untranslated RNA;Up-Regulation;Virus

PROJECT_TITLE: Astroglia-Mediated Pathogenic Mechanisms in Fragile X Syndrome (FXS)

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunotherapy;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative This study is relevant to public health because mortality following allogeneic bone marrow transplant remains a major barrier to its use for patients with all diseases which require bone marrow transplant for survival. Reduced intensity and reduced toxicity conditioning regimens that contain alemtuzumab offer the benefit of less toxicity for patients but are still hindered by transplant complications including acute graft versus host disease and graft failure. This study will test a novel Precision Alemtuzumab Dosing strategy to target alemtuzumab levels to an optimal therapeutic range which will decrease graft failure and graft versus host disease and improve immune recovery and patient outcomes.

PI_NAMEs: MEHTA, PARINDA A. (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: Acute Graft Versus Host Disease;Age;age group;alemtuzumab;Allogeneic Bone Marrow Transplantation;Allogenic;Body Surface Area;Bone Marrow Transplantation;CD4 Positive T Lymphocytes;CDW52 gene;Cell Count;Childhood;Chimerism;Clinical;Clinical Trials;conditioning;congenital immunodeficiency;curative treatments;dashboard;Data;Development;Disease;Dose;Drug Kinetics;Electronics;Enrollment;Ensure;Evaluation;Failure;falls;Feasibility Studies;Funding;graft failure;Graft Rejection;graft vs host disease;Hematology;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;high risk;humanized monoclonal antibodies;Immune;immune reconstitution;improved;Inborn Errors of Metabolism;Incidence;Individual;Infection;Infusion procedures;Institution;interest;interpatient variability;Intervention;Leukocytes;Lymphocyte;Lymphocyte Depletion;Lytic;Malignant - descriptor;Malignant Neoplasms;Marrow;Mediating;Modeling;models and simulation;Monitor;Monte Carlo Method;mortality;Non-Malignant;novel;Outcome;Patient-Focused Outcomes;Patients;Pediatric Hospitals;pharmacokinetic model;phase 2 study;Physicians;Pilot Projects;Population;post-transplant;Preparation;prevent;Prevention;Procedures;programs;Public Health;Radiation Toxicity;Recommendation;Recovery;Regimen;Reporting;Risk;Sample Size;Scheme;Sickle Cell Anemia;simulation;standard of care;Subgroup;success;T cell reconstitution;T-Lymphocyte;Technology;Testing;Thalassemia;Therapeutic;Therapeutic Effect;therapeutic target;Time;tool;Toxic effect;Toxicity due to chemotherapy;Transplant Recipients;Transplantation;transplantation therapy;user-friendly;web-based tool;Weight;Work;young adult

PROJECT_TITLE: Precision Alemtuzumab Therapy in Allogeneic HCT


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biotechnology;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Transcription factors are proteins that turn genes ON or OFF. When we sequence a new genome, we can predict transcription factors, but we cannot predict which transcription factors turn target genes ON. We are studying the different ways transcription factors turn genes ON and working to predict the regions of transcription factors responsible for this function.

PI_NAMEs: STALLER, MAX VALENTIN (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Amino Acid Sequence;Binding;Biophysics;Cataloging;Cell Culture Techniques;Cell Nucleus;cell type;Cells;Computer Models;convolutional neural network;Data;data integration;Disease;Enhancers;Evolution;Family;Gene Expression;Genes;Genome;Goals;Growth;high resolution imaging;high throughput screening;Human;Individual;Machine Learning;Movement;Mutation;Orthologous Gene;predictive modeling;promoter;Proteins;rational design;recruit;simulation;Surveys;Tertiary Protein Structure;Testing;three dimensional structure;transcription factor;Transcriptional Activation Domain;Transcriptional Regulation;Work;Yeasts

PROJECT_TITLE: Defining the protein sequence features that control transcriptional activation domain function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Maintaining genome integrity is an essential task of all cells, and imperfect repair of the damaged genome is responsible for a myriad of human diseases, ranging from aggressive cancers to defective immune systems. This research proposal aims to incorporate on-demand CRISPR technologies and quantitative biophysical approaches to investigate the complex DNA damage responses induced by DNA double-strand breaks (DSBs) in living mammalian cells. Revealing the detailed spatiotemporal information of DDR will inform how kinetics, structures, and chromatin status modulate DSB repair pathway choices, transcription activity, and their interplay with the innate immune systems, providing valuable information complementary to traditional steady-state biochemical and genetic approaches.

PI_NAMEs: LIU, YANG  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;age acceleration;Binding;Biochemical;biophysical techniques;Cells;Cellular Stress;Chromatin;Chromosomal translocation;Complement;Complex;CRISPR/Cas technology;Defect;Development;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;Double Strand Break Repair;environmental stressor;Fluorescence Microscopy;Gene Mutation;genetic approach;Genetic Research;Genetic Transcription;Genome;genome integrity;genomic locus;genotoxicity;Human;human disease;Human Genome;Immune system;Innate Immune System;insight;Kinetics;Knowledge;Link;Maintenance;Malignant Neoplasms;Mammalian Cell;Maps;Mediating;Mutation;novel;Nuclear;Pathway interactions;programs;Proteins;rapid detection;repaired;Research;Research Proposals;Resolution;response;Role;Signal Transduction;spatiotemporal;Structure;temporal measurement;Testing;Tube;Visualization

PROJECT_TITLE: Mapping the Cellular Responses to DNA Double-Strand Breaks Using On-Demand CRISPR technologies and High-resolution Fluorescence Microscopy

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Dietary Supplements;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: The human-seeking motivation of mosquitoes in response to human cues is not only essential for female mosquito reproduction, but also for the transmission of mosquito-borne viruses that affect ~400 million people worldwide. Two of these viruses have been recently shown to manipulate human skin microbiome to produce mosquito attractants and thus facilitate their transmission. This proposal will address how these viruses do so and whether this mechanism can be applicable to many more mosquito-borne viruses.

PI_NAMEs: WANG, PENGHUA  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Accounting;Acetone;Acetophenones;Affect;All-Trans-Retinol;Ammonia;anti-microbial peptide;arboviral disease;Arboviruses;Bacillus;Bacteria;bactericide;Behavior;Binding;Blood;Carbon Dioxide;Cell Nucleus;Cell Surface Receptors;cell type;Cells;Cessation of life;Chemicals;chikungunya;Chikungunya virus;Circulation;Country;Cues;Culicidae;Data;Dengue;Dengue Fever;Dengue Virus;dietary requirement;Epidermis;Esters;Family;Feeding behaviors;Female;Flaviviridae;Flavivirus;Foundations;Genetic Transcription;High Pressure Liquid Chromatography;Human;Individual;Infection;Infectious Agent;Isotretinoin;keratinocyte;Lactic acid;Lentivirus Vector;Mass Spectrum Analysis;Metabolism;microbial homeostasis;mosquito reproduction;mosquito-borne;Motivation;Mus;Nature;Odors;Oral Administration;Pathway interactions;Patients;Persons;Physiological;Productivity;Proteins;RBP4 gene;receptor expression;resistin;response;Retinaldehyde;retinaldehyde dehydrogenase;Retinoic Acid Binding;Retinoic Acid Receptor;Retinoids;Retinol dehydrogenase;Signal Transduction;Skin;skin microbiome;skin microbiota;Togaviridae;transmission process;Tretinoin;uptake;Venezuelan Equine Encephalomyelitis;Viral Proteins;viral transmission;Virus;Virus Diseases;Vitamin A;Volatilization;West Nile;Yellow Fever;ZIKA;Zika Virus;ZIKV infection

PROJECT_TITLE: The mechanism of flaviviral suppression of vitamin A metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VDT-Q(01)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE CD1 autoreactive T cells in human immune mediated skin disease D. Branch Moody, MD Contact dermatitis, psoriasis and other major human skin disease involve antigens that activate immune cells known as T cells. This proposal takes a unique approach to study lipids and small molecules that turn off T cell activation by binding and blocking a protein known as CD1a. Using human cells and tissues, as well as mice expressing human CD1a proteins, we will identify the molecules, receptors and activation pathways involved in human skin T cell response, with the goal of discovering fundamentally new disease treatments.

PI_NAMEs: MOODY, DAVID BRANCH (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Agonist;Allergens;analog;antagonist;Antigen Presentation;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;autoreactive T cell;autoreactivity;Basic Science;Binding;Blood;cell type;Cells;Clone Cells;Collaborations;Collagen;Contact Dermatitis;Contact hypersensitivity;Dermatitis;Dermatologist;design;Disease;Dominant-Negative Mutation;Functional disorder;Genes;Goals;Gossypium;Host Defense;Human;human disease;Hypersensitivity;Immune;Immune system;In Vitro;in vivo;Individual;Inflammatory;innovation;insight;interleukin-22;Investigation;Langerhans cell;Lipid Binding;Lipids;Measures;Mediating;Modeling;Molecular;molecular modeling;mouse model;Mus;Nature;Pathway interactions;Patients;Pattern;Peptide/MHC Complex;Peptides;Persons;Phenotype;Population;prevent;Production;programs;Property;Proteins;Psoriasis;pyroglyphid;receptor;Regulation;Research;Research Project Grants;response;Sampling;Science;Signal Transduction;single-cell RNA sequencing;Skin;skin disorder;small molecule;Sorting;Sphingolipids;Sphingomyelins;Structure;Surface;System;T cell regulation;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;therapeutic target;therapy development;Tissues;tool;Transgenic Mice;urushiol;Variant;Work

PROJECT_TITLE: CD1 autoreactive T cells in human inflammatory skin disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(57)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Black and Latinx adolescents in low-income urban communities are disproportionately exposed to stress and trauma stemming from systemic racism, including COVID-19 adversities, police brutality, and oppressive immigration policies, exacerbating mental health disparities; however, critical consciousness (social justice awareness and action) may serve as a protective factor. We will collect quantitative and qualitative data on Black, Latinx, and White urban adolescents over a four-year period to assess race-related stress, critical consciousness, and emotional and behavioral health trajectories and test the potentially protective role of critical consciousness. Findings will inform policy and intervention development to enhance adolescent mental health equity.

PI_NAMEs: CLARY, LAURA KATHLEEN;MENDELSON, TAMAR  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent mental health;Adult;Age;Awareness;Baltimore;behavior test;Behavioral;behavioral health;Black Populations;Black race;Caregivers;Cessation of life;Characteristics;Cities;Communities;Conscious;coping;Coronavirus;COVID-19;critical developmental period;Data;Development;Disparity;efficacy trial;eighth grade;emotion regulation;Emotional;Enrollment;Equity;ethnic diversity;Ethnic Population;experience;Exposure to;Family;Financial Hardship;food insecurity;Funding;Goals;Health;health disparity;health equity;high risk;Immigration;Individual;Inequity;insight;Institutional Racism;Intervention;Interview;Interviewer;Latinx;Link;Longitudinal Studies;loved ones;Low income;marginalization;Measures;Mental Depression;Mental Health;Methods;Modeling;multidisciplinary;National Institute of Child Health and Human Development;ninth grade;Outcome;pandemic coronavirus;pandemic disease;Participant;Personal Satisfaction;Persons;Police;Police officer;Policies;Policy Developments;Politics;Positioning Attribute;Problem behavior;Procedures;programs;protective factors;Race;racial population;racism;randomized, clinical trials;recruit;Reporting;Research;Research Personnel;resilience;resilience research;Resources;Risk;Role;Sampling;school disruption;Schools;social;Social Justice;sociodemographics;stem;Stress;stressor;Structural Racism;substance use;Surveys;System;Target Populations;Telephone;Testing;theories;therapy development;Time;Training;transition to adulthood;Trauma;traumatic stress;Trust;Twin Multiple Birth;United States;Urban Community;Well in self;Work;Youth

PROJECT_TITLE: Adolescent Stress, Critical Consciousness, and Resilience Trajectories in the Context of Structural Racism

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Malaria;Maternal Health;Maternal Morbidity and Mortality;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Rare Diseases;Vector-Borne Diseases;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_DEPT: PATHOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE  The proposed studies aim to leverage a physiologically relevant non-human primate model of both HIV and malaria to identify key immune factors that drive poor maternal and fetal outcomes during infection in pregnancy. Establishing such immune mechanisms would create potential for considerable advances in the identification and pre-clinical testing of novel therapeutic strategies to restore health in women living with HIV who become infected with malaria during pregnancy. The proposed research is relevant to the mission of the NICHD as it will significantly contribute to the ultimate goal of reducing the substantial burden of malaria infection in vulnerable women living with HIV.

PI_NAMEs: MANUZAK, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Address;Adherence;adverse outcome;African;Anemia;Animal Model;Biological;Biological Assay;Birth;Cessation of life;chemokine;Clinical;co-infection;Complex;Country;cytokine;Decidua;Decidua Basalis;Development;Disease;Endothelium;evidence base;fetal;Fetal Growth;fetal infection;Foundations;Frequencies;Functional disorder;Future;genetic signature;Geography;Goals;Health;high risk;HIV;Human;Immune;Immune response;Immune System Diseases;Immunologic Factors;Immunologics;Immunology;In Vitro;Incidence;Infant Mortality;Infection;infection risk;Inflammation;Inflammatory;innate immune function;innate immune mechanisms;innovation;Intervention;Knowledge;Low Birth Weight Infant;Lymphoid Cell;Macaca mulatta;Malaria;malaria infection;Maternal Health;Maternal Mortality;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;neutrophil;nonhuman primate;novel;novel therapeutic intervention;novel therapeutics;Outcome;Parasitemia;Parasites;Pathogenesis;Pathogenicity;Peripheral;Persons;Phenotype;Physiological;Placenta;Plasmodium;Plasmodium falciparum;Play;Population;preclinical study;Preclinical Testing;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;Prevention strategy;Production;Public Health;Publishing;Reporting;Research;Resources;Risk;Role;single-cell RNA sequencing;SIV;Spontaneous abortion;stillbirth;success;Testing;therapy design;therapy development;Tissues;transmission process;Validation;Viremia;Vulnerable Populations;Woman;Women's mortality;Work

PROJECT_TITLE: Mechanisms of innate immune dysfunction in SIV/malaria co-infection in pregnancy

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BUTLER UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Mantle cell lymphoma is a lethal cancer with no standard of care and upon disease relapse, the cancer is considered clinically incurable. The proposed project will shed light on how different sized mRNA transcripts of cyclin D1 are processed to increase their half-life and tumorigenic potential which can be applied to other disease causing genes. In addition, we will also identify recurrent fusion genes that arise from two distinct parent genes that are a consequence of cyclin D1 induced chromosomal instability which in the long-term can be used as potential biomarkers that will help us stratify MCL patients for molecularly targeted therapies.

PI_NAMEs: MASAMHA, CHIONISO PATIENCE (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Affect;B lymphoid malignancy;B-Cell Acute Lymphoblastic Leukemia;B-Cell Lymphomas;B-Lymphocytes;Binding;Biological Markers;Case Study;CCND1 gene;Cell Line;cell motility;Cell Nucleus;cell type;Cells;Characteristics;Chromosomal Instability;Chromosomal Rearrangement;Chromosomal translocation;Chromosome abnormality;Chronic;Clinical;Code;Cyclin D1;Cytoplasm;Data;Disease;Distal;Enhancers;Event;Frequencies;fusion gene;Gene Deletion;Gene Expression;Gene Fusion;gene product;Generations;Genes;Genetic;Genetic Enhancer Element;Genetic Transcription;genome integrity;Goals;Half-Life;Hematopoietic Neoplasms;Housekeeping;Human;Individual;innovation;insight;knock-down;Length;Lesion;Lymphocyte;Lymphoma cell;Malignant Neoplasms;Mantle Cell Lymphoma;Measures;Messenger RNA;Molecular;molecular targeted therapies;mRNA Precursor;Mutation;novel;Nucleotides;Parents;patient stratification;Patients;Pattern;Phenotype;Physiological;Poly(A) Tail;Polyadenylation;potential biomarker;premature;Process;promoter;Proteins;Publishing;Recurrence;Recurrent disease;Regulation;Research;Rest;RNA Splicing;Role;Sampling;Signal Transduction;standard of care;Technology;Terminator Codon;Testing;Third Generation Sequencing;Transcript;transcriptome;tumorigenic;Work

PROJECT_TITLE: Elucidating the mechanism and consequences of aberrant cyclin D1 gene expression

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Our EDRN BCC proposal aims to address the critical clinical unmet needs of over-treatment and under-treatment in prostate cancer. We plan to develop in vitro diagnostic multivariate index assays (IVDMIA) that combine a panel of biomarkers into a single-valued numerical index for the conservative treatment of prostate cancer patients through the Active Surveillance (AS) approach. The discovery, validation, and translation of prostate cancer biomarkers into clinical diagnostics, as well as the development of clinical-grade assays will be accomplished through partnerships with EDRN BCC, CVC, and DMCC components, and the diagnostics industry.

PI_NAMEs: CHAN, DANIEL WANYUI (contact);ZHANG, HUI

PROGRAM_OFFICER_NAME: KOHAAR, INDU

PROJECT_TERMS: Address;Adoption;assay development;Biological Assay;Biological Markers;biomarker development;biomarker discovery;biomarker panel;biomarker validation;Biopsy;cancer biomarkers;cancer diagnosis;Cancer Patient;cancer therapy;cancer type;candidate marker;Certification;Classification;CLIA certified;Clinical;clinical development;clinical diagnostics;Clinical Research;Clinical Treatment;clinically significant;Communities;Computer Models;cost;Detection;Development;Diagnostic;Disease;disorder risk;Early Detection Research Network;Enrollment;experience;FDA approved;follow-up;GDF15 gene;Glycoproteins;glycoproteomics;Goals;growth differentiation factor 1;Health;high risk;Immunoassay;improved;in-vitro diagnostics;indexing;Industry;industry partner;innovation;interest;Laboratories;laboratory development;laser capture microdissection;Lasers;Malignant neoplasm of prostate;Mass Spectrum Analysis;men;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;multidisciplinary;multimodality;novel;Numerical value;overtreatment;Patient Triage;Patients;Performance;Population Surveillance;Post-Translational Protein Processing;predictive marker;Predictive Value;Principal Investigator;Procedures;progression risk;Prostate;prostate cancer cell;prostate cancer risk;Prostate Cancer therapy;Protein Glycosylation;Proteins;Proteomics;Reaction;Receptor Protein-Tyrosine Kinases;research clinical testing;Resources;Risk;Serum;single cell analysis;Specificity;Specimen;Surveillance Program;syndecan;Target Populations;Technology;technology platform;TIE-2 Receptor;Time;tissue biomarkers;Tissues;Translating;Translations;Universities;Urine;Validation;verification and validation;Work

PROJECT_TITLE: BCC for Prostate Cancer: Discovery and Translation of Biomarkers for Clinical Unmet Needs


PI_NAMEs: CHAN, DANIEL WANYUI (contact)

PROJECT_TERMS: Adherence;base;Biological Markers;biomarker validation;Clinical;clinical practice;Collaborations;Communication;Diagnostic;Early Detection Research Network;Ensure;experience;Fostering;Goals;Industry;insight;Laboratories;Leadership;Malignant neoplasm of prostate;meetings;member;operation;programs;public-private partnership;Research Personnel;Resources;Structure;success;Teleconferences;timeline;Translations;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Globally, acute lymphoblastic leukemia (ALL) is the most common cancer in children 0-14 years of age, with an estimated 74,000 incident cases each year and a disproportionate number of years of life lost in Asia, the Middle East/North Africa, and sub-Saharan Africa. In order to address genetic risk of this disease in diverse populations, we will examine existing genotype data for ~12,000 children with ALL in the Childhood Cancer and Leukemia International Consortium. Specifically, we propose to: 1) estimate heritability for ALL in diverse populations, 2) conduct comprehensive genomewide and local discovery for variants associated with ALL, and 3) create population-specific polygenic risk scores for risk of ALL and examine their relationship with non-genetic risk factors.

PI_NAMEs: BASU, SAONLI ;SPECTOR, LOGAN G. (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: 14 year old;Acute Lymphocytic Leukemia;Acute T Cell Leukemia;Address;Adult;Africa South of the Sahara;African;African American;African American population;Age;American;Architecture;Articulation;Asia;Asian;B-Cell Acute Lymphoblastic Leukemia;Birth;Birth Weight;Breast Feeding;causal variant;Child;Childhood Acute Lymphocytic Leukemia;Childhood Leukemia;Clinical Research;Cytogenetics;Data;Data Set;Diagnosis;Disease;disorder risk;East Asian;epidemiologic data;epidemiology study;Ethnic Origin;ETV6 gene;European;Evaluation;Far East;Future;GATA3 gene;Genetic;genetic architecture;genetic epidemiology;Genetic Models;Genetic Risk;Genome;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Germ Lines;Heritability;improved;Incidence;Infrastructure;International;Latino Population;leukemia;Low Prevalence;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Methods;Middle East;Middle Eastern;Mixed B- and T-Cell Leukemia;non-genetic;North African;Northern Africa;novel;Pacific Islander;Parental Ages;Patients;Pattern;PAX5 gene;Perinatal;Planet Earth;polygenic risk score;Population;Population Heterogeneity;Research;Resources;Risk;Risk Factors;risk prediction;risk variant;Sample Size;SEER Program;sex;Single Nucleotide Polymorphism;socioeconomics;South Asian;southeast Asian;Southeastern Asia;Subgroup;Susceptibility Gene;TCF3 gene;Time;trend;United States;Validation;Variant;years of life lost

PROJECT_TITLE: Genomics of childhood acute lymphoblastic leukemia in the Childhood Cancer and Leukemia International Consortium

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Clinical Research;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

PI_NAMEs: ZHANG, HUI  (contact)

PROJECT_TERMS: Adoption;Affect;assay development;Bioinformatics;Biological;Biological Assay;Biological Markers;biomarker development;biomarker discovery;biomarker panel;biomarker validation;Biopsy;Body Fluids;cancer biomarkers;cancer diagnosis;Cancer Patient;cancer risk;candidate marker;candidate selection;Characteristics;Circulation;Classification;Clinical;Collaborations;Collection;Data;Data Coordinating Center;Detection;Development;Disease;Disease Progression;disorder risk;Early Detection Research Network;Early Diagnosis;Early Intervention;Effectiveness;Enrollment;Evaluation;Future;genomic signature;Gleason Grade for Prostate Cancer;glycoproteomics;glycosylation;Immunoassay;Immunohistochemistry;improved;in-vitro diagnostics;indexing;innovation;Knowledge;laboratory development;Lead;Leadership;Liquid substance;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Measurement;member;Meta-Analysis;Modeling;Monitor;multimodality;multiple omics;Nature;Newly Diagnosed;overtreatment;Pathological Staging;Patient Triage;Patients;Performance;Phase;Play;Population Surveillance;Post-Translational Protein Processing;progression risk;prostate cancer cell;prostate cancer progression;prostate cancer risk;Proteins;Proteome;Proteomics;Protocols documentation;PSA screening;Public Health;Recording of previous events;Reporting;Research;research clinical testing;Research Project Grants;Resources;Role;Sampling Errors;Screening for Prostate Cancer;Serum;Signal Transduction;single cell analysis;single cell proteins;Specimen;Staging;Stains;statistics;success;Target Populations;Technology;Time;tissue biomarkers;Tissues;tool;Translating;Translations;ultrasound;Urine;Urology;Validation;Variant;Work

PROJECT_TITLE: Biomarker Development Laboratory


PHR: Overall Component Project Narrative Mobility and balance disorders are common among the aged and contribute to reduced physical activity, falls, injuries, disability, loss of independence and health care utilization. Our multidisciplinary group of collaborative investigators are dedicated to foster optimal mobility and balance among older Americans, both through improved understanding of their causes and through development of preventive and therapeutic interventions to reduce falls and maintain independence.

PI_NAMEs: BRACH, JENNIFER S (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Address;Age;age related;age related changes;aged;Aging;American;Applications Grants;Area;Attention;Award;Awareness;Basic Science;Biology;Biology of Aging;Biomedical Engineering;Biometry;Body System;Brain;Capsicum;Cells;Clinical;Clinical Sciences;Collaborations;collaborative environment;Communities;Complex;cost;data management;Dedications;Development;disability;Disabling;Discipline;Discipline of Nursing;Disease;education research;Epidemiology;Epigenetic Process;equilibration disorder;Equilibrium;fall risk;falls;Fostering;Funding;Future;Genetic;Geroscience;Goals;Grant;health care service organization;health care service utilization;Health Services Research;Health system;Image;implementation science;improved;improved mobility;Individual;Informatics;Injury;innovation;Institution;interdisciplinary approach;Interdisciplinary Study;Intervention;Knowledge;Leadership;Learning;Long-Term Care;Measurement;Measures;Medicine;Mentors;Mobility decline;Mobility disability;Molecular and Cellular Biology;motor control;multidisciplinary;Muscle;neglect;Neurosciences;novel;older adult;Older Population;Organelles;Organism;Outcome;Pathway interactions;Pharmacology;Physical activity;Pilot Projects;pilot test;podcast;Population;Preparation;preventive intervention;Productivity;programs;Proteomics;Public Health;rapid growth;recruit;Rehabilitation therapy;Research;Research Personnel;Resources;Science;Scientist;Signal Transduction;Support System;System;Telemedicine;Testing;Therapeutic Intervention;Tissues;Training;translational potential;Translational Research;Work

PROJECT_TITLE: Pittsburgh Older Americans Independence Center


NIH_SPENDING_CATS: Aging;Clinical Research;Health Services

PI_NAMEs: RESNICK, NEIL M. (contact)

PROJECT_TERMS: age related;Aging;American;Applications Grants;Assessment tool;Award;Basic Science;behavior influence;Body System;Capsicum;career;career development;Clinical;Clinical Research;Clinical Sciences;Clinical Services;Collaborations;Competence;Dedications;design;Development;Development Plans;Discipline;education research;educational atmosphere;Educational Curriculum;Educational Status;Enrollment;Environmental Risk Factor;Equilibrium;Evaluation;experience;Faculty;Feedback;Financial Support;flexibility;Fostering;Foundations;Funding;Future;Generations;Goals;Grant;Grant Review;Health Services;Health Services Research;improved;innovation;Institution;Interdisciplinary Study;K-Series Research Career Programs;Lead;Leadership;learning strategy;Manuscripts;Mentors;mid-career faculty;Modeling;Molecular;Monitor;multidisciplinary;peer;Peer Review;Pilot Projects;Polishes;Postdoctoral Fellow;pre-doctoral;Process;programs;Publishing;recruit;Research;Research Personnel;Research Project Grants;Resources;Schedule;Scholars Program;Science;Self Assessment;Series;skills;skills training;social factors;Source;Structure;success;Talents;Time;Training;training opportunity;Training Programs;Training Support;translational approach;Translational Research;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;visiting scholar;Vocational Guidance;Wages;Writing

PROJECT_TITLE: Research Education Component (REC)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Childhood Leukemia;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Mental Health;Neurosciences;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Latino children experience increased incidence of acute lymphoblastic leukemia (ALL), as well as disparities in ALL treatment toxicities, relapse, and survival – however, less is known about neurocognitive outcomes in Latino survivors, which has important implications for educational attainment and quality of life. The proposed study will employ an accelerated longitudinal cohort design to examine for the first time ever 1) the extent to which neurocognitive response to ALL chemotherapy differs by ethnicity; and 2) the relative contribution of clinical, socioeconomic, cultural, and biological variability in explaining neurocognitive disparities among childhood ALL survivors. This line of research is well-poised to identify: a) subpopulations of youth at greatest risk for neurocognitive difficulties and in greatest need of intervention; b) critical points in treatment/survivorship to employ intervention strategies to mitigate disparities in neurocognitive outcome; and c) potential targets for intervention.

PI_NAMEs: BROWN, AUSTIN L;RAGHUBAR, KIMBERLY PAULINE (contact)

PROJECT_TERMS: Acceleration;Accounting;Acculturation;Acute leukemia;Acute Lymphocytic Leukemia;Address;Adult;Aftercare;Attention;bilingualism;Biological;Biological Factors;cerebrovascular;Child;Childhood Acute Lymphocytic Leukemia;Childhood Leukemia;Clinical;Clinical Management;Clinical Oncology;cohort;Data;design;Diagnosis;Disparity;disparity reduction;Doctor of Philosophy;economic outcome;Education;Employment;English Language;Enrollment;Environment;Epidemiologist;Epidemiology;ethnic disparity;Ethnic Origin;Ethnic Population;Event;executive function;experience;Foundations;Funding;General Population;Genetic;Geographic Locations;Goals;Grant;health disparity;improved;improved outcome;inattention;Incidence;Individual;Infrastructure;Injury;Intervention;Latino;Latino Population;Leukemia Acute Lymphoblastic Chemotherapy;Longitudinal cohort;Malignant Childhood Neoplasm;Measures;Modeling;multi-ethnic;multidisciplinary;Native American Ancestry;Neighborhoods;Neurocognitive;Neurocognitive Deficit;Neuropsychology;neurotoxic;neurotoxicity;Newly Diagnosed;non-genetic;novel;Outcome;Participant;patient population;Patients;Performance;Phenotype;Population;Principal Investigator;processing speed;protective factors;Quality of life;recruit;Relapse;Research;Research Personnel;Resources;response;Risk;Risk Factors;Sampling;Seizures;Short-Term Memory;social health determinants;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Survivors;survivorship;Symptoms;Time;translational potential;treatment adherence;treatment comparison;treatment disparity;treatment response;Treatment-related toxicity;white matter injury;Work;Youth

PROJECT_TITLE: An Integrative Approach to Evaluate Neurocognitive Disparities in Latinos Undergoing Treatment for Childhood Leukemia.


NIH_SPENDING_CATS: Aging;Clinical Research;Health Services;Patient Safety

PI_NAMEs: GREENSPAN, SUSAN L (contact)

PROJECT_TERMS: Advisory Committees;Aging;American;Attention;Award;Awareness;Basic Science;Biology;Biomedical Engineering;Capsicum;Clinical;Clinical Investigator;Clinical Research;Clinical Services;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Communities;community advisory board;Community Health;Data Collection;data management;Discipline of Nursing;education research;Ensure;Equilibrium;experience;Fellowship;Fostering;Funding;Goals;Grant;Grant Review;Health Services Research;Health system;Healthcare;Human;Informatics;innovation;insight;Institution;Institutional Review Boards;Interdisciplinary Study;International;Laboratories;Leadership;Manuscripts;medical schools;member;Monitor;multidisciplinary;Neurology;novel;Occupational activity of managing finances;Outcome;Participant;Pharmacy facility;Physical Medicine;podcast;Population;Principal Investigator;Process;programs;Psychiatry;Public Health;Publications;Records;Research;Research Personnel;Resources;Safety;Science;Scientist;Series;System;Technology;technology research and development;Telemedicine;Training;Translational Research;United States National Institutes of Health;Universities;Visit;web site;Work

PROJECT_TITLE: Leadership & Administrative Core (LAC)


ORG_CITY: BALTIMORE

PROJECT_TERMS: Address;assay development;Bioinformatics;Biological Assay;Biological Markers;biomarker discovery;biomarker evaluation;biomarker identification;biomarker panel;biomarker performance;biomarker validation;Biometry;Biopsy;cancer biomarkers;cancer diagnosis;Cancer Diagnostics;cancer therapy;cancer type;Certification;Classification;Clinical;clinical assay development;Clinical Chemistry;clinical epidemiology;Clinical Investigator;clinical practice;Clinical Research;Clinical Treatment;clinically significant;Collaborations;computerized tools;design;Detection;Development;Diagnostic;diagnostic assay;Diagnostic Procedure;Disease;Early Detection Research Network;Enrollment;experience;FDA approved;follow-up;Funding;Genomics;Goals;Guidelines;Health;improved;in-vitro diagnostics;indexing;Industrialization;Industry;innovation;Institution;International;Knowledge;Laboratories;Leadership;Licensing;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Medical;Mission;Morbidity - disease rate;mortality;multidisciplinary;non-invasive monitor;Numerical value;Ovarian;overtreatment;Pathology;Patient Monitoring;patient population;Patient Triage;Performance;Physicians;Population Surveillance;potential biomarker;predictive modeling;Principal Investigator;Procedures;product development;Productivity;progression risk;Prostate;Proteomics;Publications;quality assurance;Quality Control;Research;Research Design;research study;Resources;ROC Curve;Scientist;Screening for cancer;Serum;Specificity;success;Surveillance Program;Technology;technology development;Testing;tissue biomarkers;Translating;Translations;Treatment outcome;tumor;Universities;Urine;Urology;Validation;validation studies;Work

PROJECT_TITLE: Biomarker Reference Laboratory


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Health Services;Physical Activity;Prevention

PI_NAMEs: ALBERT, STEVEN M (contact)

PROJECT_TERMS: actigraphy;Affect;Aging;Agreement;American;Assessment tool;Assisted Living Facilities;Audiotape;Capsicum;Clinic;Clinical;Clinical assessments;Clinical Research;Clinical Trials;Cohort Studies;Collaborations;Communities;community advisory board;community collaboration;Computers;Consent;Consultations;Data Set;Databases;Dedications;design;Development;Devices;Dissemination and Implementation;dissemination strategy;Engineering;Enrollment;Equilibrium;Equipment;experience;fall risk;falls;Fatty acid glycerol esters;Feedback;Fostering;Foundations;Funding;Grant;Health system;human subject;Image;implementation efforts;innovation;Institution;Instruction;interdisciplinary approach;Interdisciplinary Study;interest;Internet;Laboratories;Lead;Leadership;Libraries;Long-Term Care;longitudinal dataset;Machine Learning;Manuscripts;Measurement;member;Methodology;Methods;Modeling;Muscle;neglect;Neighborhoods;novel;older adult;Older Population;Outcome;outreach;Participant;patient oriented;Physical activity;Physical environment;Platinum;Population;portability;Productivity;programs;Provider;Public Health;Publications;recruit;Registries;Research;Research Personnel;research study;Resources;Schools;screening;searchable database;secondary analysis;Series;Services;Site;Skilled Nursing Facilities;Source;Specimen;Standardization;Study Subject;System;Technology;Testing;tool;Training;ultrasound;usability;walkability

PROJECT_TITLE: Resource Core (RC)


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: UNIVERSITY OF PUERTO RICO RIO PIEDRAS

PHR: Narrative The IDGeNe program will be the first training program for undergraduates of its kind at the University of Puerto Rico (UPR), a premier research-intensive Hispanic Serving Institution in the USA. This program aims to attract students into the Genomics field by providing meaningful, in depth, experiences in areas of research associated with Genomics and by providing a series of academic and professional activities that will prepare a new generation of promising underrepresented students to insert themselves into this growing biomedical field. In view of the history and track record of the UPR, this grant will succeed in increasing the diversity of the field by increasing the number of Hispanic researchers in the 21st Century Genomics workforce.

PI_NAMEs: GARCIA-ARRARAS, JOSE E (contact)

PROGRAM_OFFICER_NAME: TINGLE, SHARNA R

PROJECT_TERMS: Address;Area;Bioinformatics;biological research;Biology;Biomedical Research;career;cohort;Computers;Data Science;Development;Doctor of Philosophy;Education;Educational workshop;Ethics;experience;Faculty;Future;Gender;Generations;Genetic;genome analysis;Genomic medicine;Genomics;Goals;graduate school;Grant;Hispanic;Hispanic Populations;Hispanic-serving Institution;Institution;interest;Internships;Island;Laboratories;Manuscripts;Medical;member;Mentors;minority student;Modeling;Molecular Biology;Neurosciences;next generation;Occupations;Oral;organ regeneration;Population;Privatization;Probability;professor;programs;Public Health;Puerto Rico;Race;Recording of previous events;recruit;Reporting;Research;Research Personnel;response;San Francisco;Series;skill acquisition;skills;social;Social status;Societies;statistics;Students;summer research;System;tool;Training;Training Activity;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;university student;Wisconsin;Work

PROJECT_TITLE: Increasing Diversity in Genomics for the Next generation (IDGeNe)

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Aging;Clinical Research;Neurosciences

PI_NAMEs: ROSANO, CATERINA  (contact)

PROJECT_TERMS: Accelerometer;Address;Affect;age related;age related changes;Aging;American;Amyloid;Behavior;Biological;Biology;Biology of Aging;Birth;Brain;Budgets;Capsicum;Cardiopulmonary;Cerebrum;Clinical;Cognitive;Cohort Studies;Collaborations;Communication;density;Development;Education;Electromyography;epidemiology study;Equilibrium;Equipment;Evaluation;Exercise;fall risk;field trip;Funding;Generations;Heart;Human Resources;in vivo;in-vivo diagnostics;innovation;insight;Institution;Knowledge;Laboratories;Leadership;Locomotion;Locomotor adaptation;Longevity;Measures;Micronutrients;Mission;Mitochondria;mitochondrial dysfunction;Mobility decline;Monitor;Motor;Movement;multidisciplinary;Muscle;muscular structure;Musculoskeletal structure;Near-Infrared Spectroscopy;nerve supply;Nervous System;neuroimaging;neuromechanism;novel;novel marker;novel strategies;Physiological;Physiology;prevent;Research;Research Personnel;Research Project Grants;research study;Resources;response;Rest;Spinal Cord;Structure;System;Techniques;Testing;Training;Training Support;virtual;Walking;way finding;wearable device;Work;working group

PROJECT_TITLE: RC-ISC


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Drug Abuse (NIDA only);Methamphetamine;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LITTLE ROCK

ORG_NAME: INTERVEXION THERAPEUTICS, LLC

ORG_STATE: AR

PHR: PROJECT NARRATIVE InterveXion has created humanized methamphetamine (METH)-binding variable regions and modified antibody constant domains that when combined are likely to produce an anti-METH antibody for treating METH use disorder with a target dosing frequency of only once every 2-3 months. The studies in this proposal are designed to identify which combination of antibody segments are most effective in reducing METH stimulant effects, to develop a scalable manufacturing platform, and to test the lead candidate’s safety in toxicology studies. When completed, this medication will be ready for initial clinical trials and if successful would significantly improve patient outcomes and adherence to therapy while lowering the cost and burden of delivering healthcare for patients with METH use disorder.

PI_NAMEs: STEVENS, MISTY WARD (contact)

PROGRAM_OFFICER_NAME: SOUSA, JASON CARLOS

PROJECT_TERMS: Adherence;Affinity;Amendment;Animals;antagonist;Antibodies;Behavior Therapy;Behavioral;Binding;Biological Assay;Brain;candidate selection;cell bank;Cell Line;Chronic;clinic ready;Clinical;clinical development;Clinical Protocols;Clinical Research;Clinical Trials;Cognitive;contingency management;cost;Data;design;Development;Diagnosis;disability;Dose;Drug Kinetics;efficacy study;Fab Immunoglobulins;FDA approved;first-in-human;Frequencies;Goals;Grant;Half-Life;Health;Health Care Costs;Healthcare;healthy volunteer;Home;Human;humanized monoclonal antibodies;immunogenicity;Immunoglobulin G;improved;In Vitro;Infusion procedures;lead candidate;Length;manufacture;manufacturing process;medication compliance;meetings;Methamphetamine;methamphetamine effect;Methamphetamine overdose;methamphetamine use;Methamphetamine use disorder;Modeling;Modification;Monoclonal Antibodies;Motor Activity;Mutation;nonhuman primate;Outcome;Participant;Patient Care;Patient Compliance;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;phase 1 study;Population;pre-Investigational New Drug meeting;Preclinical Testing;Preparation;Production;programs;Rattus;Recovery;Relapse;Research;Research Design;response;Risk;Rodent;Running;Safety;stable cell line;Step Tests;Stimulant;Testing;Time;Toxicokinetics;Toxicology;Treatment Cost;Vaccines;Visit;Work;Writing

PROJECT_TITLE: IND-enabling program for a long-acting anti-methamphetamine monoclonal antibody for treating methamphetamine use disorder

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


NIH_SPENDING_CATS: Aging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PERERA, SUBASHAN  (contact)

PROJECT_TERMS: Address;adjudication;Adverse event;Aging;American;Big Data;Biological;Biometry;Capsicum;cardiovascular health;career;Cellular Phone;Classification;Clinic Visits;Clinical Data;Cluster Analysis;cohort;Cohort Studies;Collaborations;Communities;Complex;complex biological systems;Computational Biology;Computational Technique;Computerized Medical Record;cost;CXCL14 gene;Data;Data Analytics;data centers;data management;Data Security;data sharing;data standards;deep learning;Development;dimension reduction;disability;Education;Educational workshop;Ensure;Equilibrium;Exercise;Faculty;Funding;Gait;Gait speed;Goals;graduate student;Grant;handheld mobile device;Health;Health Sciences;Healthcare;Human Resources;improved mobility;Informatics;Infrastructure;innovation;Institution;Joints;Laboratories;Leadership;Learning;Logic;Machine Learning;Measures;Medicine;Methodology;Methods;Mission;Modeling;novel;novel strategies;older adult;Online Systems;Peer Review;Physical therapy;Population;predictive modeling;Process;professor;Prognosis;Progress Reports;Publications;Quality Control;random forest;regression trees;Rehabilitation therapy;Reproducibility;Research;Research Design;Research Personnel;Resources;response;service providers;Services;signal processing;Source;System;Systems Biology;Tablets;Techniques;Telemedicine;theories;Time;Training;Training Support;Update;web site;Work

PROJECT_TITLE: RC-DMAIC


NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative We propose to develop and apply proteomics tools for understanding the mechanisms involved in the regulatory networks crucial to a new set of neuroepigenetic syndromes. Understanding the underlying epigenetic mechanisms behind these novel neuroepigenetic disorders has incredible potential, as their disruption leads to neurodevelopmental delays, neurological degeneration, congenital anomalies and epilepsy.

PI_NAMEs: GARCIA, BENJAMIN A (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Affect;Applications Grants;Biochemical;Biological Assay;Brain;Cell Differentiation process;Cell Line;Cell model;Central Nervous System;Chromatin;Chromatin Structure;combinatorial;congenital anomaly;Congenital Epilepsy;Corpus Callosum;Craniofacial Abnormalities;Data;Defect;Development;developmental disease;Disease;DNA Methylation;DNA-Binding Proteins;Epigenetic Process;epigenome;ES Cell Line;exome sequencing;Fetal Development;Fetal Monitoring;Fetus;Gene Expression;Gene Expression Profile;Gene Mutation;Genes;Genetic Transcription;Genome;Genomics;Germ Lines;Germ-Line Mutation;Goals;Heart failure;Histone H3;Histone H3.3;histone modification;Histones;Human;human disease;improved;in utero;In Vitro;Intellectual functioning disability;Knock-out;Lead;Length;Link;Maintenance;Malignant neoplasm of brain;Malignant Neoplasms;Mass Spectrum Analysis;Methodology;Methods;Microcephaly;Missense Mutation;Modification;Molecular Conformation;Mouse Embryonic Stem Cells;mouse model;Mus;Muscle hypotonia;mutant;mutant mouse model;Mutation;N-terminal;nano;Nanotechnology;Nerve Degeneration;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;Neurodevelopmental Problem;Neurologic;Neurons;new therapeutic target;novel;Nucleosomes;oculomotor;Outcome;Patients;Pattern;Pediatric Hospitals;pediatric patients;Phenotype;Philadelphia;Post-Translational Protein Processing;Proteins;Proteome;Proteomics;Research Personnel;Sampling;Seizures;Series;Signal Transduction;Somatic Mutation;Stable Isotope Labeling;Structure;Syndrome;Tail;Thinness;Time;Tissues;tool;Untranslated RNA;Variant;Xenopus laevis

PROJECT_TITLE: Quantitative mass spectrometry for comprehending epigenetic mechanisms in a new underlying neurological developmental disorder

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Aging;Biotechnology

PI_NAMEs: FINKEL, TOREN  (contact)

PROJECT_TERMS: Acceleration;Adoption;age related;age related changes;Aging;aging biomarker;aging process;American;Animal Model;Animals;Area;Back;Basic Science;Biological;Biological Markers;Biological Models;Biological Process;Biological Products;Biological Sciences;Biology;Biology of Aging;biomarker development;biomarker identification;Capsicum;Chemicals;Clinical;clinical care;clinical practice;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complement;Consultations;Core Facility;CRISPR screen;Dedications;design;Development;Doctor of Philosophy;Drosophila genus;Equilibrium;exosome;Faculty;first-in-human;Fostering;Foundations;Funding;Future;Gait;gene therapy;Genes;Genetic;Geriatrics;Geroscience;Goals;hallmarks of aging;healthspan;high throughput analysis;high throughput screening;Human;improved;Individual;Inflammation;innovation;insight;instrumentation;International;Intervention;Investments;Knowledge;Laboratories;Language;late life;Leadership;Link;Medical;member;metabolomics;Methodology;microbiome;Mission;Mobility decline;Molecular;molecular drug target;Molecular Target;molecular targeted therapies;Muscle function;muscle physiology;muscle progenitor cell;Neurosciences;novel;novel marker;novel therapeutics;Organism;Pharmacology;Phenotype;Pilot Projects;pre-clinical;Pre-Clinical Model;preservation;prevent;Reagent;recruit;Research Personnel;Research Support;Research Training;Resources;Rodent;Science;Scientist;screening;single-cell RNA sequencing;small molecule libraries;square foot;System;targeted treatment;Techniques;Technology;tool;Translating;translational study;Translations;trend;Visit;whole genome;Work;Zebrafish

PROJECT_TITLE: RC-BMAC


PI_NAMEs: FORMAN, DANIEL E. (contact)

PROJECT_TERMS: Adherence;Aging;American;Applications Grants;Area;Award;Biology;Capsicum;Cardiology;Clinical;Clinical Sciences;Collaborations;Communities;community advisory board;community based research;Data;Development;Doctor of Pharmacy;Endowment;Equilibrium;Ethics;Faculty;Fostering;Funding;Future;Geriatrics;Geroscience;Goals;Growth;Health;Healthcare Systems;Individual;innovation;interdisciplinary approach;Interdisciplinary Study;International;K-Series Research Career Programs;Leadership;Letters;Medicine;meetings;member;Mentors;mid-career faculty;Monitor;multidisciplinary;Outcome;Peer Review;Pharmacy facility;Physical Medicine;Physical Rehabilitation;Pilot Projects;Population;Privacy;Process;Productivity;professor;Publications;Publishing;Rehabilitation therapy;Research;Research Methodology;Research Personnel;Research Project Grants;Review Literature;Safety;Scientist;success;Techniques;translational approach;Translational Research;United States National Institutes of Health;Universities;Update;web site

PROJECT_TITLE: Pilot/Exploratory Studies Core (PESC)