ORG_CITY: LOMA LINDA

ORG_NAME: VA LOMA LINDA HEALTHCARE SYSTEM

PHR: Impaired skeletal fracture healing, including non-union fractures, osteoporotic fractures, and unhealed stress fractures developed during active military service, are prevalent in the VA patient population. They represent a significant health issue resulting in substantial healthcare costs and human suffering. A defective osteoclastic regulation of the coupled bone formation is a frequent cause for compromised fracture healing. This study investigates a novel mechanism by which soluble microvesicles (MV) released from osteoclasts mediate the coupled bone regeneration during fracture healing. If successful, this work provides significant new information about the etiology of impaired fracture healing. It may also lead to development of novel MV-based osteoanabolic therapies for fracture healing that would improve the quality of life of patients and reduce healthcare costs for managing unhealed fractures. Accordingly, this study is highly relevant to the VA patient care mission.

PI_NAMEs: LAU, KIN-HING WILLIAM (contact)

PROJECT_TERMS: Acceleration;angiogenesis;Antibodies;bone;Bone callus;bone cell;bone fracture repair;bone healing;Bone Regeneration;bone strength;C57BL/6 Mouse;Calvaria;Cartilage;cartilaginous;Cell Physiology;Cell Separation;cell type;Cells;Chondrocytes;cohort;Complex;cortical bone;cost;Coupled;Data;Defect;Development;Differentiation and Growth;Dose;Economics;effective therapy;Endothelial Cells;Etiology;Exhibits;Female;Femoral Fractures;Fracture;Frequencies;Gender;healing;Health;Health Care Costs;Healthcare;Histologic;Human;Impairment;improved;In Vitro;in vitro activity;in vivo;Injections;insight;Ligands;Link;Literature;male;Mechanics;Mediating;Membrane;microvesicles;military service;Mission;Modeling;morphogens;Mus;Natural regeneration;neovascularization;novel;novel therapeutics;older patient;Osteoblasts;Osteoclasts;Osteogenesis;osteogenic;osteoporosis with pathological fracture;osteoprogenitor cell;overexpression;Patient Care;patient population;Patients;Phase;Physiologic Ossification;Play;prevent;Process;Property;Quality of life;receptor;Regimen;Regulation;Research;response;Risk Factors;Role;sex;Signal Transduction;Site;skeletal;Sprague-Dawley Rats;Stress Fractures;Surface;Testing;Therapeutic;Time;vesicular release;Work;young adult

PROJECT_TITLE: Osteoclastic Regulation of Local Bone Formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ENDB-P (01)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Lung

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The goal of this study is to advance a bed sensing technology platform through real-world patient testing. Doing so will improve our ability to recognize the earliest signs of impending hospitalizations in high-risk patients, days to weeks before symptoms are self-recognized and self-reported.

PI_NAMEs: KING, KEVIN R (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Acute;Adherence;Adoption;Adult;Arrhythmia;Atlases;base;Beds;Biological;Blood;Cardiology;Cardiopulmonary;Caring;Cessation of life;Chronic Obstructive Pulmonary Disease;Clinic Visits;Clinical;Clinical Research;cohort;Collaborations;Computer software;Computerized Medical Record;computerized tools;Contracts;cost;County;Data;Data Aggregation;Data Set;Dehydration;Detection;detection platform;Development;Diagnostic;Dimensions;Disease;Early Diagnosis;Enrollment;ethnic diversity;Event;Family;Frequencies;Gastrointestinal Hemorrhage;gender diverse;Geography;Goals;Health;Heart;Heart Diseases;Heart failure;Hematological Disease;high dimensionality;high risk;Hispanic;Hispanic Populations;Home;hospice environment;Hospitalization;Hour;Human;Impaired cognition;improved;Individual;Intervention;Interview;Kidney Diseases;Learning;Lung;Lung Diseases;Mattresses;Measures;Mechanics;Methods;model generalizability;Modeling;Monitor;Movement;Musculoskeletal;Nature;Notification;outreach;participant enrollment;Patient Participation;patient population;Patient Self-Report;patient subsets;Patients;Performance;Physiological;Pneumonia;Population;population health;prevent;Probability;Provider;Pulmonary Embolism;Recurrence;Reporting;Research;respiratory;Risk;Sampling;sensor;sensor technology;Sepsis;service organization;Signal Transduction;Sleep;Sleep Disorders;social;success;Symptoms;Technology;technology platform;Testing;time interval;Training;training data;Underrepresented Populations;Visualization software

PROJECT_TITLE: Advancement of an Impending Hospitalization Detection Platform

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (O1)]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: LOUISVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Narrative This NIEHS Short-Term Institutional Training Grant (5T35ES014559) application is to request annual support for 8 medical student trainees for a 10 week training experience for the next 5 years. The overarching scientific theme of research that links our faculty to this T35 Training Grant is the common interest of the faculty in research training of medical students in our laboratories in elucidating the health outcomes of exposure of normal and obese individuals to various environmental chemicals. In addition, we will use the T35 Training Grant to entice our medical students into our Distinction in Research Track, designed to allow students to pursue research interests throughout the years 2-4 of medical school curriculum with an eye toward building a pipeline of diverse translational clinician-researchers in the future.

PI_NAMEs: CAVE, MATTHEW C;CONKLIN, DANIEL JOSEPH;STATES, J CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Authorship;Award;Chemical Exposure;Chronic Disease;Clinical;Clinical Research;Conflict of Interest;Data;design;Diabetes Mellitus;disadvantaged background;Education;Eligibility Determination;Environment;Environmental Health;experience;fabrication;Funding;Grant;Health;health science research;hormone regulation;human subject;IACUC;Institutional Review Boards;interest;Laboratories;Malignant Neoplasms;Medical;medical schools;Medical Students;meetings;Mentors;Mentorship;Metabolism;National Institute of Environmental Health Sciences;non-alcoholic fatty liver disease;Obesity;Outcome;peer;Peer Review;Persons;Physicians;Plagiarism;Positioning Attribute;posters;programs;Public Health;Publications;Reproducibility;Research;Research Project Grants;Residencies;responsible research conduct;Scientist;skills;Specialist;Structure;Student recruitment;Students;summer student;symposium;Training;Training Programs;Training Support;Translational Research;underrepresented minority student;Vertebrates;Work

PROJECT_TITLE: Summer Environmental Health Sciences Training Program


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Talaromycosis (penicilliosis) is a life-threatening infection caused by the dimorphic fungus Talaromyces marneffei endemic in Southeast Asia and has a mortality of 30% in patients with advanced HIV disease. Delay in diagnosis is a major risk factor for death. The current culture-based diagnosis is not sensitive during the early stage of disease and takes up to 14 days. In this project, we will determine how a new antigen-detection test can be used in real-life clinical settings to accelerate the diagnosis and whether it can be used to screen for early disease. We aim to reduce mortality by making an earlier diagnosis thereby enabling early treatment and prevention of talaromycosis.

PI_NAMEs: LE, THUY  (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Admission activity;advanced disease;Amphotericin;Amphotericin B;antigen detection;Antigens;Asia;biobank;Blood;burden of illness;Caring;Cause of Death;CD4 Lymphocyte Count;Cell secretion;Cell Wall;Cells;Cessation of life;China;Clinic;Clinical;Clinical Research;cohort;Country;Data;Detection;detection method;detection test;Development;Diagnosis;diagnosis evaluation;Diagnostic;diagnostic algorithm;diagnostic strategy;Diagnostic tests;diagnostic value;Disease;Disease Progression;disorder risk;Early Diagnosis;Early identification;early screening;Early treatment;Enrollment;Enzyme Immunoassay;Epidemiology;experience;falls;Fever;fungus;Goals;Grant;high risk;HIV;HIV therapy;Hong Kong;Hospitalization;Hospitals;Human;Immunoassay;Immunocompetent;Immunocompromised Host;improved;Individual;Infection;innovation;International AIDS;Interruption;Itraconazole;Life;mannoproteins;Monitor;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mycoses;new technology;novel;novel diagnostics;Organism;Outcome;Outpatients;pathogenic fungus;Patient Care;Patient Recruitments;Patient-Focused Outcomes;Patients;Penicillium;Persons;Plasma;Positioning Attribute;pre-clinical;Prevalence;prevent;Prevention;Prevention strategy;prognostic performance;Prospective Studies;Proteins;Rapid diagnostics;Reference Standards;Reporting;Research;research clinical testing;Research Personnel;Risk Factors;Sampling;screening;Sensitivity and Specificity;Serum;Site;Southeastern Asia;Specificity;Specimen;Sterility;Symptoms;Talaromyces;Test Result;Testing;Therapy Evaluation;Time;tool;Translating;Translations;treatment trial;United States National Institutes of Health;Universities;Urine;Vietnam;working group;World Health Organization

PROJECT_TITLE: Making an early diagnosis of talaromycosis - an approach to reduce morbidity and mortality in advanced HIV disease in Southeast Asia

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: 08 Project Narrative The coordinated firing of millions of neurons in the human brain gives rise to the diverse set of experiences, emotions, thoughts, and sensations that make up the human condition. Despite the central importance of neuronal physiology to human health and disease, our understanding of this complex field remains incomplete due to a lack of tools that can reliably report on membrane potential. This proposed research will develop and apply new optical tools to study neuronal membrane potential in cells and in circuits.

PI_NAMEs: MILLER, EVAN WALKER (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TITLE: Interrogating Neuronal Membrane Potential Dynamics with Optical Voltage Sensors

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Genetics;Mental Health;Mental Illness;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Neurexins are key regulators of synapses that control properties as diverse as the release probability, postsynaptic receptor composition, and endocannabinoid signaling, and that are genetically linked to neuropsychiatric diseases such as schizophrenia, autism, and Tourette syndrome. Despite much effort, it is unclear what functions neurexins perform, how they perform these functions, and why mutations in neurexin genes predispose to neuropsychiatric disorders. The present application addresses these questions in a multi-disciplinary effort that combines mouse genetics with broad functional analyses of synapses, thereby providing insight into the role of neurexins in shaping synaptic circuits and into the mechanisms by which neurexins predispose to neuropsychiatric disease.

PI_NAMEs: SUDHOF, THOMAS C. (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Address;Adhesions;Adopted;Affinity;Alternative Splicing;Applications Grants;Area;Astrocytes;autism spectrum disorder;Behavioral;Binding;Binding Proteins;Biological;Biological Models;Brain;Brain region;Brain Stem;Cell Adhesion Molecules;Cell Nucleus;cell type;Cellular biology;Complex;Cre driver;Data;Dystroglycan;Electrophysiology (science);endocannabinoid signaling;experimental study;extracellular;Funding;Gene Mutation;Genes;Gilles de la Tourette syndrome;glycosylation;Goals;Grant;Hippocampus;In Situ Hybridization;Individual;information processing;insight;interdisciplinary approach;Knock-in Mouse;Knockout Mice;Ligand Binding;Ligands;Link;Medial;Mediating;Methods;Molecular;mouse genetics;multidisciplinary;Mutant Strains Mice;Mutation;neural circuit;neurexophilin;Neuroglia;Neurons;neuropsychiatric disorder;novel;olfactory bulb;oligodendrocyte progenitor;optical imaging;Output;Paper;Post-Translational Protein Processing;postsynaptic;postsynaptic neurons;precursor cell;presynaptic;presynaptic neurons;Probability;Property;Protein Chemistry;Protein Isoforms;Publishing;Regulation;Risk Factors;risk variant;Role;Schizophrenia;Shapes;Site;Specific qualifier value;superresolution microscopy;Susceptibility Gene;Synapses;synaptic function;Synaptic Receptors;synaptogenesis;Testing;trafficking;transcriptomics;trapezoid body;Virus Diseases

PROJECT_TITLE: Function of Neurexins

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative We propose to investigate the presence of a disease-prone population of smooth muscle cells in normal blood vessels and the contribution this population(s) make to cardiovascular illness characterized by smooth muscle proliferation. We postulate that many of these diseases are caused by expansion of the disease-prone cell pool. Proof of this hypothesis will open new therapeutic possibilities for treating thoracic and abdominal aortic aneurysms and potentially heart attacks, stroke and peripheral vascular disease.

PI_NAMEs: SIMONS, MICHAEL  (contact);TELLIDES, GEORGE

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Abdominal Aortic Aneurysm;Adipocytes;Aneurysm;Aorta;Arterial Fatty Streak;Atherosclerosis;Blood Vessels;bone;Bone Marrow;calcification;Cardiovascular system;Cartilage;Cell Reprogramming;cell type;Cells;cerebral cavernous malformations;Characteristics;Chronic;Clonal Expansion;Clone Cells;Coronary artery;Cytometry;Data;Development;Dilatation - action;Disease;Endothelial Cells;Endothelium;Exhibits;fascinate;Genetic;Genetic Transcription;Goals;Growth;Health;Heterogeneity;Human;human disease;Image;Inflammation;Link;Macrophage;Maps;Medial;Mesenchymal;Mesenchymal Stem Cells;Minority;Molecular;Molecular Analysis;Mononuclear;mouse model;Mus;Myocardial Infarction;novel therapeutics;Organ Donor;Paint;pathogen;Pathogenesis;Pathogenicity;Pathologic;Pathology;Peripheral Vascular Diseases;Phenotype;Physiologic Ossification;Population;Process;Proliferating;pulmonary arterial hypertension;Pulmonary Hypertension;Reporting;response;Signal Transduction;single-cell RNA sequencing;Site;Smooth Muscle;Smooth Muscle Myocytes;stemness;Stroke;Therapeutic;Thoracic Aortic Aneurysm;Time;Time Series Analysis;tool;Vascular Diseases;Vascular Smooth Muscle

PROJECT_TITLE: Vascular smooth muscle cell heterogeneity and disease

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Pediatric;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARATIVE Climate change is increasing the frequency and intensity of wildfires in the US. Wildfires could have important detrimental impacts on infant health through air pollution, psychosocial stress, and community disruption. In order to inform mitigation strategies, the proposed project will document the burden of wildfire exposure across the US and its impacts on infant health and mortality.

PI_NAMEs: BOUDREAUX, MICHEL H (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Acceleration;Adult;Air;Air Pollutants;Air Pollution;anthropogenesis;Area;atmospheric modeling;Birth;Birth Records;Birth Weight;Calendar;Censuses;Characteristics;Climate;climate change;Collection;Color;Communities;Consumption;County;Data;data standards;Death Records;Disadvantaged;Droughts;Environmental Health;Epidemiology;Event;Evolution;experience;Exposure to;fine particles;Fire - disasters;forest;Frequencies;Geography;Gestational Age;Growth;Health;health care service utilization;health service use;Health Services Research;Heterogeneity;Hospital Records;hospital services;Hospitals;Individual;Infant;Infant Health;Infant Mortality;Inpatients;large scale data;Length;Life;Link;Live Birth;Long-Term Effects;low socioeconomic status;lower income families;Measurement;Measures;Methods;Modeling;Monitor;mortality;Mothers;Neonatal Mortality;Neonatology;novel;Outcome;Particulate Matter;Pattern;perinatal health;pollutant;Pollution;Population;Population Group;Pregnancy;prenatal;Proliferating;Psychosocial Stress;Public Health;Public Policy;Race;Records;Research Personnel;Resolution;Resources;Risk;rurality;Sampling;Science;Severities;Smoke;sociodemographics;Socioeconomic Status;Source;temporal measurement;Testing;Time;treatment effect;trend;United States;Variant;Vital Statistics;Wildfire

PROJECT_TITLE: Wildfires and Infant Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(90)S]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The magnitude and duration of viremia in vertebrate hosts influences arbovirus emergence, transmission, geographic spread, and disease severity. The innate immune mechanisms by which arboviruses are cleared from the circulation, and the mechanisms arboviruses employ to evade this clearance, are poorly understood. This project will define mechanistically how blood-borne arboviruses are cleared. The knowledge gained from these studies could facilitate improved control of arbovirus transmission and treatment of arboviral disease.

PI_NAMEs: MORRISON, THOMAS E (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: acquired immunity;Alpha Virus;Amino Acids;Antibodies;antiviral drug development;antiviral immunity;arboviral disease;Arbovirus Infections;Arboviruses;Arginine;Binding;Biochemical;Biological Assay;Blood;cell type;Cells;Chikungunya virus;Circulation;Collection;Complement;Data;Development;diphtheria toxin receptor;Disease;Distal;Enzyme-Linked Immunosorbent Assay;experimental study;Flavivirus;Geography;Glycoproteins;Goals;Human;human disease;Immunoglobulin G;Immunoglobulin M;Immunohistochemistry;improved;In Situ Hybridization;in vivo;Individual;inhibitor;innate immune mechanisms;insight;Integration Host Factors;Knockout Mice;Knowledge;Kupffer Cells;Licensing;Ligands;Liver;Lysine;Mass Spectrum Analysis;Mediating;mouse model;Mus;mutant;Mutation;Mutation Analysis;natural antibodies;new therapeutic target;O'nyong'nyong;O'nyong-nyong virus;Orthobunyavirus;particle;Pathogenesis;Pathogenicity;Pathway interactions;Phagocytes;Population;Positioning Attribute;Post-Translational Protein Processing;Predisposition;Proteins;Proteomics;reverse genetics;Risk Factors;Role;scavenger receptor;Severity of illness;Sorting;Spleen;Splenectomy;Surface;System;therapy development;Tissues;Transgenic Mice;transmission process;Ubiquitin;Ubiquitination;uptake;Vertebrates;Viral;viral RNA;Viral Structural Proteins;viral transmission;Viremia;Virion;Virus;Work;Zika Virus

PROJECT_TITLE: Clearance of Blood-Borne Arboviruses

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: NARRATIVE – Overall The broad objective of the Center for Virtual Imaging Trials is to develop and provide a comprehensive virtual platform to assess the clinical performance of medical imaging technologies or applications from design to use. In its first phase, the Center focuses on Computed Tomography (CT). The Center will provide essential resources to optimize the design and use of CT technologies for improved human health.

PI_NAMEs: SAMEI, EHSAN  (contact)

PROGRAM_OFFICER_NAME: SHABESTARI, BEHROUZ

PROJECT_TERMS: Acceleration;Adoption;Anatomy;Area;Clinical;clinical application;clinical efficacy;clinical imaging;clinical predictors;Clinical Trials;clinically relevant;Collaborations;Communities;Computer software;Computers;cost;design;Detection;detector;diagnostic value;digital;Digital Mammography;Effectiveness;effectiveness evaluation;Ensure;Esthetics;Ethics;Evaluation;Exercise;experimental study;Fostering;Goals;Health;Human;Image;Image Analysis;imaging biomarker;Imaging Device;imaging modality;imaging system;Imaging Techniques;Imaging technology;improved;in silico;Infrastructure;Knowledge;Mammography;Manufacturer;Measures;Medical;Medical Imaging;Methodology;Methods;Modality;model building;Modeling;Motion;patient oriented;Patient-Centered Care;Patients;Perception;Performance;Perfusion;Phase;Positioning Attribute;pre-clinical;Protocols documentation;Qualifying;Radiation;Radiation Dose Unit;radiation risk;Radiology Specialty;Reader;reconstruction;Reproducibility;Research;Research Personnel;Resource Development;Resources;Safety;Scientist;screening;Services;simulation;Source;statistics;System;Technology;technology research and development;technology training;Testing;Time;tool;Training;tumor;Uncertainty;Universities;virtual;virtual imaging;virtual patient;virtual platform;Work;X-Ray Computed Tomography

PROJECT_TITLE: Center for Virtual Imaging Trials


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Administrator;Advisory Committees;Agreement;Area;Clinical Trials;Collaborations;Communication;Computer software;Computers;Consultations;design;Development;Engineering;Ensure;Evaluation;Expenditure;federal policy;Fostering;Funding;Goals;Health Technology;Human Resources;Image;image processing;image reconstruction;Infrastructure;Lead;Leadership;Machine Learning;meetings;member;Monitor;Occupational activity of managing finances;Principal Investigator;Productivity;Radiology Specialty;Recommendation;Regulation;Reporting;research and development;Research Personnel;Resources;Retirement;Scientist;Senior Scientist;Services;simulation;software infrastructure;success;synergism;technology research and development;technology training;Training Activity;United States National Institutes of Health;Universities;virtual imaging;Work

PROJECT_TITLE: Administration


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Clinical Research;Diabetes;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Recent literature has established that adults with Type 1 Diabetes (T1D) suffer from a high risk of fractures, particularly at the hip. This proposal will define the skeletal mechanisms underlying this increased fracture risk with comprehensive assessments of hip bone structure, quality, and strength among older adults with T1D. Further identification of the glycemic factors that contribute to skeletal fragility will allow clinicians to develop rational approaches to prevent fractures in patients with T1D.

PI_NAMEs: YU, ELAINE WEI-YIN (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: 3-Dimensional;Address;Adult;Advanced Glycosylation End Products;Age;age acceleration;age related changes;age related decline;Age-Related Bone Loss;Area;Biomechanics;bone;Bone Density;bone fragility;bone health;Bone Matrix;bone quality;bone strength;Bone structure;cohort;Complication;Complications of Diabetes Mellitus;Continuous Glucose Monitor;cortical bone;Data;Development;Diabetes Mellitus;Dual-Energy X-Ray Absorptiometry;Ethnic Origin;Exhibits;Femur;Finite Element Analysis;follow-up;Fourier Transform;Fracture;fracture risk;Glucose;glycemic control;Glycosylated hemoglobin A;Health;high risk;hip bone;Hip Fractures;Hip region structure;Image;improved;in vivo;Incidence;Individual;Inferior;insight;Insulin-Dependent Diabetes Mellitus;Intervention;Knowledge;Life Expectancy;Literature;Maps;Measures;mechanical properties;men;Microvascular Dysfunction;multidisciplinary;Nature;Neck;non-diabetic;novel;older adult;Osteogenesis;Outcome;Oxidative Stress;Patients;pentosidine;Periodicity;Peripheral;Phenotype;Postmenopause;prevent;prospective;Prospective Studies;Race;recruit;Risk;Serum;sex;skeletal;Skeleton;Skin;Specimen;Structure;substantia spongiosa;Techniques;Testing;Thinness;Woman;Women's study;X-Ray Computed Tomography

PROJECT_TITLE: Delineating mechanisms of skeletal fragility in older adults with Type 1 Diabetes

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SEGARS, WILLIAM P (contact)

PROJECT_TERMS: 3-Dimensional;Adult;Age;Anatomy;Blood flow;Brain;Cardiac;Characteristics;Childhood;Clinical;clinical application;clinically relevant;Computed Tomography Scanners;computerized;Computers;Contrast Media;cost;Data;Databases;design;Development;Disease;Dose;Evaluation;Exclusion;Exhibits;experimental study;Future;Heart;Heart Diseases;Height;Heterogeneity;Hospitals;human model;Image;Image Analysis;imaging approach;Imaging Device;Imaging technology;Individual;individual patient;innovation;Intravenous;Kidney;Laboratories;Lesion;Libraries;Liquid substance;Liver;Lung;Magnetic Resonance Imaging;Malignant Neoplasms;Mathematics;Medical Imaging;Methods;Modality;Modeling;Motion;Normal tissue morphology;Organ;Paper;patient population;Patients;Performance;Perfusion;phantom model;Phase;physiologic model;Physiological;Population;Pregnancy;Protocols documentation;PubMed;Race;radiation absorbed dose;Reader;Reading;Research;Research Personnel;Research Project Grants;Resources;respiratory;Series;sex;simulation;Source;Technology;Texture;Time;Tissue Model;Tissues;tool;Universities;Update;Variant;virtual;virtual imaging;virtual patient;virtual platform;Weight;Work;X-Ray Computed Tomography

PROJECT_TITLE: TR&D Project 1: Virtual Patients


NIH_SPENDING_CATS: Diabetes;Pediatric

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE ATP-sensitive potassium (KATP) channels in pancreatic β-cells couple glucose metabolism to insulin secretion; dysfunction of these channels underlies a number of human diseases including neonatal diabetes, congenital hyperinsulinism, DEND syndrome and type 2 diabetes. The goal of this project is to understand the structural mechanisms governing the formation and activity of KATP channels in health and disease in order to design better drugs to treat diseases caused by channel dysfunction.

PI_NAMEs: SHYNG, SHOW-LING  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Affect;Anti-diabetic Drugs;ATP-Binding Cassette Transporters;Binding;Biochemical;biochemical tools;Biogenesis;biophysical tools;Blood Vessels;Brain;Carbamazepine;Cells;Cellular Metabolic Process;Chemicals;Complex;conformational conversion;crosslink;CRSP3 gene;Cryoelectron Microscopy;Data;Defect;design;Detergents;Developmental Delay Disorders;Dimerization;Disease;Distal;Drug Design;Epilepsy;Functional disorder;Funding;gain of function mutation;Genes;Genetic Polymorphism;Glucose;glucose metabolism;Glyburide;Goals;Grant;Health;Heart;hormone regulation;Hormone secretion;Human;human disease;Hypoglycemia;Impairment;improved;inhibitor;innovation;insulin secretion;inward rectifier potassium channel;Ion Channel;ischemic injury;Knowledge;Lead;Ligands;loss of function mutation;Mediating;Membrane;Membrane Proteins;Methods;MgADP;MgATP;Molecular;Molecular Chaperones;molecular dynamics;Monitor;mutant;Mutation;N-terminal;nanodisk;neonatal diabetes mellitus;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleotides;Outcome;particle;Persistent Hyperinsulinemia Hypoglycemia of Infancy;Pharmaceutical Preparations;pharmacologic;Phosphatidylinositol 4,5-Diphosphate;Physiological;Positioning Attribute;Potassium;Potassium Channel;preservation;protein complex;Publishing;reconstitution;Regulation;repaglinide;Resolution;Review Literature;Risk;Structure;Structure of beta Cell of islet;Structure-Activity Relationship;sulfonylurea receptor;Surface;Syndrome;Testing;Therapeutic;trafficking;Transmembrane Domain

PROJECT_TITLE: Structural basis of KATP channel gating


PROJECT_TERMS: 3-Dimensional;Algorithms;Anatomy;Artificial Intelligence;Biological Models;Cardiac;Clinical;clinical imaging;Code;Communities;Computed Tomography Scanners;Computer software;Computing Methodologies;Data;Data Set;design;detector;Dose;Evaluation;flexibility;Generations;Geometry;Goals;high resolution imaging;human subject;Image;imaging modality;Imaging technology;in silico;Knowledge;Manufacturer;Medical Imaging;Methods;Modeling;Monte Carlo Method;Motion;multiple datasets;new technology;Patients;Performance;Perfusion;Phase;photon-counting detector;Process;Protocols documentation;prototype;radiation absorbed dose;Radiation Dose Unit;Radiation Scattering;radiomics;Reader;reconstruction;Research;respiratory;Roentgen Rays;Scheme;Signal Transduction;simulation;Specific qualifier value;Specificity;Speed;System;system architecture;Technology;tool;Training;Tube;usability;user-friendly;Validation;Variant;verification and validation;virtual;virtual imaging;virtual patient;virtual platform;Work;X-Ray Computed Tomography

PROJECT_TITLE: TR&D Project 2: Virtual Scanners


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: EPITEL, INC.

ORG_STATE: UT

PHR: This grant proposal aims to commercialize a remote EEG monitoring platform that uses wearable EEG sensors worn on the scalp below the hairline. The platform is quickly deployable and meant to be used by emergency department and intensive care unit staff during neurological emergencies. The goal is to empower physicians in community and rural hospitals who do not have neurology or access to EEG to better treat their patients through remote monitoring by neurologists.

PI_NAMEs: LEHMKUHLE, MARK J. (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Accident and Emergency department;Adhesives;Adoption;Adult;Applications Grants;blind;Blinded;Bluetooth;budget impact;Capital;care costs;Caring;Cessation of life;Child;Clinical;Clinical Trials Design;cloud platform;commercialization;commercialization readiness;Communities;Community Hospitals;Computer software;Contracts;cost;cost effective;Costs and Benefits;Data;data exchange;design;Development;Diagnosis;Economic Models;Electroencephalography;Emergency Situation;Emergent care;empowerment;Exclusion;Foundations;Freedom;Goals;Good Manufacturing Process;Health;health economics;Healthcare;Hospitals;improved;Institution;Intellectual Property;Intensive Care Units;Investments;Legal patent;Letters;Life;manufacture;Marketing;Medical;Modeling;Monitor;Neurological emergencies;Neurologist;Neurology;Outcome;Outcomes Research;overtreatment;Patients;payment;pediatric emergency;Peer Review;Phase;Physicians;Positioning Attribute;Process;Production;prospective;randomized, clinical trials;Randomized, Controlled Trials;remote grading;remote monitoring;Research;Resources;Risk;Running;Rural Hospitals;Sales;Scalp structure;screening;Screening procedure;Secure;Seizures;sensor;Services;System;Tablets;Technology;Time;Traction;Translations;transmission process;trial planning;Universities;Utah;wearable device;wireless

PROJECT_TITLE: REMI Platform for Remote EEG Monitoring


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Cystic Fibrosis;Lung;Orphan Drug;Pediatric;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE: The proposed research is relevant to public health, because it advances non-invasive, radiation-free imaging and proteomic biomarkers to diagnose and monitor lung disease. The work focuses pediatric cystic fibrosis, but it accelerates the use of these technologies to evaluate novel therapies in clinical trials and to measure outcomes in patients with a range of diseases, including asthma and COPD. Thus, the research is relevant to the part of the NIH’s mission that pertains to applying knowledge to enhance health, lengthen life, and reduce illness.

PI_NAMEs: CLEVELAND, ZACKARY I (contact);ZIADY, ASSEM G

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Acceleration;Adolescence;Adult;Affect;Age;airway remodeling;Anti-Inflammatory Agents;Asthma;Biological Markers;Blood;Blood Proteins;Blood specimen;Bronchi;Bronchiectasis;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Bronchoscopy;Cessation of life;children with cystic fibrosis;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Trials;cohort;Coupled;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Data Analyses;Demographic Factors;Diagnosis;Disease;Disease Progression;early cystic fibrosis;Early Diagnosis;evidence base;functional decline;Functional disorder;functional loss;Future;Genetic Diseases;Goals;Health;Heterogeneity;high risk;Image;image guided;imaging modality;Impairment;improved;Individual;individualized medicine;Infection;Inflammation;innovation;Intervention;Investigation;Knowledge;Lavage;Life;Life Expectancy;Liquid Chromatography;Liquid substance;loss of function;Lung;Lung Diseases;lung injury;Lung Transplantation;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measures;Methods;Mission;Modeling;Molecular;molecular phenotype;Molecular Profiling;Monitor;Mucous body substance;Mutation;Nature;novel;novel therapeutics;Outcome;Outcome Measure;Pathologic;Pathology;Pathway interactions;Patients;personalized approach;Plasma;predictive marker;prevent;prognostic tool;prospective;Proteomics;Public Health;Pulmonary Cystic Fibrosis;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary Pathology;Radiation;Reaction;reconstruction;Regulator Genes;Research;Resolution;Respiratory Failure;Respiratory Tract Infections;risk prediction model;Scanning;Sensitivity and Specificity;Serum;Severity of illness;Specialized Center;specific biomarkers;Specimen;Spirometry;Structural defect;tandem mass spectrometry;Technology;Testing;Time;tool;Translating;Translations;United States;United States National Institutes of Health;ventilation;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Imaging and Molecular Phenotyping of Cystic Fibrosis Lung Disease

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LO, JOSEPH Y (contact)

PROJECT_TERMS: Address;Adoption;Algorithms;Anatomy;Artificial Intelligence;artificial intelligence algorithm;Benchmarking;beneficiary;biomedical imaging;Categories;Classification;Clinical;Clinical Data;clinical imaging;Clinical Trials;Communities;comparative;Complex;Computer Assisted;Data;Data Science;Data Set;Databases;deep learning;deep learning model;design;Detection;Development;Disease;disease diagnosis;Education;Elements;Ensure;Evaluation;experience;Future;generative models;Human;Image;Image Analysis;Imaging Phantoms;imaging science;Imaging technology;improved;indexing;Institution;interoperability;Ionizing radiation;Lesion;Machine Learning;machine learning model;Manufacturer;Mathematics;Measurement;Measures;Medical;Medical Imaging;member;Modality;model design;Modeling;Morphology;open data;Patients;Perception;Performance;Phase;Protocols documentation;quantitative imaging;Radiation Dose Unit;radiologist;radiomics;Reader;Reading;Reproducibility;Research;research clinical testing;Resource Development;Resources;Scientist;Speed;System;Technology;Technology Assessment;technology development;technology research and development;Testing;Texture;tool;Training;Transcend;Translating;trend;Uncertainty;Variant;virtual;virtual imaging;virtual patient;virtual platform;Work;X-Ray Computed Tomography

PROJECT_TITLE: TR&D Project 3: Virtual Readers


PI_NAMEs: KAPADIA, ANUJ J. (contact)

PROJECT_TERMS: 3-Dimensional;Academia;Address;Bioinformatics;Biomedical Engineering;Biometry;Clinical;clinical imaging;Code;Collaborations;Communities;Computer software;Computers;Data;Data Set;design;Development;disease model;Documentation;education resources;Educational Curriculum;Educational workshop;Engineering;Ensure;Experimental Designs;Feedback;Fostering;Generations;Goals;Grant;Health Technology;Human Resources;Image;Imaging Device;Imaging technology;improved;Industry;Institution;Instruction;interest;Internet;Journals;LinkedIn;Machine Learning;Manuals;Medical;Medical Imaging;Medicine;meetings;Mission;Modeling;new technology;Online Systems;Patients;Persons;Physicians;Physics;Postdoctoral Fellow;Process;programs;Publications;Publishing Peer Reviews;Radiology Specialty;Reader;Reproducibility;Research;Research Personnel;Residencies;Resources;Running;Sampling;Science;Scientist;Series;simulation;Site;social media;Software Engineering;Specialist;Stream;Students;symposium;Technology;technology training;tool;Training;Training Activity;Twitter;virtual;virtual imaging;virtual patient;virtual platform;Virtual Tool;web site;Work;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Technology Training and Dissemination


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: MADISON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Heart failure is currently the leading cause of death worldwide due to the lack of effective therapies to replace the damaged cardiac tissue following injury. We identified that inhibition of succinate dehydrogenase by malonate can regenerate the adult heart following a myocardial infarction. This proposal aims to identify the cellular and molecular mechanisms by which succinate dehydrogenase inhibition promotes adult heart regeneration. Mechanisms elucidated in this proposal will advance the translational potential of targeting succinate dehydrogenase for treatment of heart failure.

PI_NAMEs: MAHMOUD, AHMED I (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Adult;angiogenesis;Angiogenic Factor;Animals;Birth;Cardiac;Cardiac Myocytes;cardiac regeneration;cardioprotection;Cause of Death;cdc Genes;Cell Cycle;cell type;Citric Acid Cycle;Complex;coronary fibrosis;Data;Development;DNA Damage;Dose;effective therapy;Electron Microscopy;Electron Transport;Embryo;Endothelium;Enzymes;Exhibits;experimental study;Family suidae;fatty acid metabolism;fatty acid oxidation;Fibrosis;Genetic Transcription;Glycolysis;Heart;heart damage;Heart failure;heart failure with reduced ejection fraction;heart function;Heart Transplantation;Human;improved;in vivo;Infarction;Injury;Ischemia;Knock-out;lipidomics;Malonates;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;metabolomics;microscopic imaging;Mitochondria;Molecular;Morbidity - disease rate;Morphology;mortality;Mus;Myocardial;Myocardial Infarction;Myocardium;Myofibroblast;Natural regeneration;Neonatal;neonatal mice;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Nuclear RNA;Operative Surgical Procedures;Oxidation-Reduction;oxidative DNA damage;Patients;Physiology;Pilot Projects;Play;porcine model;postnatal;Prevention;Production;programs;Proliferating;Public Health;Publishing;regeneration following injury;regeneration potential;regenerative;regenerative therapy;Reperfusion Injury;Resolution;Respiration;response;restoration;revascularization;Role;Structure;Succinate Dehydrogenase;Testing;Therapeutic;Time;Tissues;Toxic effect;transcription regulatory network;transcriptome sequencing;translational potential;Translations;Transplantation;Treatment Failure;Vertebrates

PROJECT_TITLE: Metabolic Reprogramming of the Adult heart to a Regenerative State

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Nanotechnology;Prevention;Vaccine Related

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project narrative COVID-19 continues to be a global health crisis. The efforts of developing therapeutics for COVID-19 are worldwide and unprecedented. Molnupiravir, nirmatrelvir and remdesivir are successful examples of such efforts. This project will provide important information on whether these drugs can be used together for therapeutic synergy and if nanoformulation shows organ-targeted superiority such as for the lung, the major organ affected by COVID-19 in terms of severity.

PI_NAMEs: YAN, BINGFANG  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;breakthrough infection;calcium phosphate coating;Carboxylesterase 1;Cells;Cessation of life;Characteristics;Clinical Trials;clinically significant;Complex;Coronavirus;COVID-19;COVID-19 impact;COVID-19 mortality;COVID-19 patient;COVID-19 therapeutics;COVID-19 vaccination;CYP3A4 gene;Disease Progression;Dose;Drug Interactions;Drug Kinetics;Drug Targeting;Ensure;Enzymes;Exhibits;Family;future pandemic;global health;glycosylation;Hepatocyte;Hospitalization;Human;Hydrolysis;Immunity;Incubated;individual variation;Infection;Infection prevention;Inflammatory;inhibitor;Left;Lipids;Lung;Medicine;Metabolism;Molecular Conformation;molnupiravir;Mutagenesis;Mutation;nano;nanoformulation;nanoparticle;news;nirmatrelvir;Organ;originality;oxidation;Parents;pathogen;Paxlovid;Peptide Hydrolases;Pharmaceutical Preparations;pharmacologic;Phase;Phosphorylation;pill;Preparation;Prodrugs;Proteins;Public Health;receptor;remdesivir;Risk Reduction;Ritonavir;RNA-Directed RNA Polymerase;Safety;Sampling;SARS-CoV-2 inhibitor;Science;Severities;single-cell RNA sequencing;stem;Surface;Symptoms;synergism;System;targeted delivery;Testing;Therapeutic;therapeutic target;Treatment Efficacy;uptake;vaccine development;vaccine immunotherapy;Vaccines;Viral;Viral Genome;Viral Physiology;Virus Replication

PROJECT_TITLE: Metabolism-based interactions and organ-targeted delivery of molnupiravir, nirmatrelvir and remdesivir

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(82)]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;Hyperbaric Oxygen;Inflammatory Bowel Disease;Microbiome

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Ulcerative colitis patients hospitalized for acute flares represent one of the highest risk and cost populations cared for in the United States, yet the treatment algorithm for these patients has remained unchanged for over a decade due to their exclusion from traditional drug development programs. We have previously demonstrated that the use of hyperbaric oxygen therapy in these patients improves disease activity, optimizes response to intravenous steroids early in the hospitalization, and prevents progression to biologics or colectomy. In the current proposal we aim to expand on our prior work by confirming the efficacy of hyperbaric oxygen therapy in this patient population through a large pivotal clinical trial, while also expanding our understanding of disease pathogenesis through tissue-based transcriptomics of neutrophils, epithelial cells, and the microbiome of participants enrolled in this clinical trial.

PI_NAMEs: BONNER, LAUREN BALMERT;DULAI, PARAMBIR SINGH (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Acute;Air;Algorithms;arm;Atmospheric Pressure;bile acid metabolism;Bile Acids;Biological Products;Breathing;Caring;Cells;Chronic;Clinical;clinical remission;Clinical Trials;cohort;Colectomy;Collection;cost;design;digital;Disease;Disease Outcome;Dose;Double-Blind Method;drug development;effective therapy;Epithelial Cells;Epithelium;Exclusion;experimental study;Feces;Firmicutes;Flare;Frequencies;Functional disorder;Future;Global Change;gut microbiota;Hemorrhage;HIF1A gene;high risk;high risk population;Hospital Costs;hospital readmission;Hospitalization;Hospitals;host-microbe interactions;Human;Hyperbaric Oxygen;Hyperbaric Oxygenation;Hypoxia;Immune;Immune system;improved;Infection;Inflammation;inflammatory marker;Injury;Intestinal Mucosa;Intravenous;Mediating;Medical;Messenger RNA;Metabolism;metabolomics;Metagenomics;metatranscriptomics;Microbe;microbial;microbial composition;microbiome;Morbidity - disease rate;mortality;Mucin-2 Staining Method;Mucous body substance;Mucous Membrane;neutrophil;novel;novel therapeutics;Orphan;Outcome;Oxygen;participant enrollment;Pathogenesis;Pathogenicity;Pathway interactions;patient population;Patients;Phase;phase II trial;Population;Postoperative Period;pressure;prevent;Prevention;primary outcome;Production;Program Development;programs;progression risk;Randomized;Rectum;Resolution;response;Risk;Salvage Therapy;Sample Size;Side;small molecule;STAT3 gene;Steroid therapy;Steroids;Therapeutic;tissue injury;tissue oxygenation;Tissues;transcriptome;transcriptomics;Treatment Effectiveness;Treatment Efficacy;treatment response;Ulcerative Colitis;United States;Work

PROJECT_TITLE: Hyperbaric Oxygen Therapy for Ulcerative Colitis Patients Hospitalized for Moderate to Severe Flares: A Phase 3 Multi-Center, Randomized, Double-Blind, Sham-Controlled Trial


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The goal of this proposal is to integrate the anatomy as well as the physiology of coronary atherosclerosis to improve identification of stable individuals who will subsequently experience heart attack in the future. Extensive clinical data will be leveraged to perform anatomic and physiologic measurements on these images, and integrated models that combine both of these types of measurements will be constructed to determine a patient’s risk of heart attack.

PI_NAMEs: MIN, JAMES K;STONE, PETER HOWARD (contact)

PROJECT_TERMS: acute coronary syndrome;Acute myocardial infarction;Anatomy;Angiography;Arterial Fatty Streak;arterial remodeling;Arteries;attenuation;Behavior;Biomechanics;Blood;Blood flow;calcification;Categories;Cessation of life;Characteristics;Clinical;clinical care;Clinical Data;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary computed tomography angiography;Diagnosis;Dimensions;Dose;Endothelium;Enrollment;Evaluation;experience;Functional disorder;Future;General Population;Goals;Grant;high risk;Image;improved;Individual;innovative technologies;insight;Ischemia;Liquid substance;Measurement;Methods;Modeling;Morbidity - disease rate;mortality;Multicenter Trials;Myocardial Infarction;Necrosis;Nested Case-Control Study;novel;novel diagnostics;particle;Patient Care;patient population;Patient risk;Patients;Pattern;Physiological;Physiology;pressure;prognostic;prognostication;Property;Quantitative Evaluations;Randomized;residence;Risk;risk stratification;Rotation;Severities;shear stress;Stable Populations;Stenosis;Stress;Symptoms;Techniques;Thrombus;Time;tool;ultrasound;United States National Institutes of Health;Validation;virtual;Work;X-Ray Computed Tomography

PROJECT_TITLE: Integrating Coronary Atherosclerosis with Physiologic Features for Optimized Risk Stratification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(02)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_DEPT: PSYCHIATRY

PHR: Neuromodulatory nuclei are small groups of neurons that change brain network function and are centrally important to motivation, adaptation, and treatments for many mental disorders. This project uses advanced statistical modeling to relate activity in nuclei that release dopamine and other neuromodulators to widespread brain networks and activity patterns. The knowledge we expect to gain offers better understanding of brain function and self-regulation, and promises many new tools for optimizing human cognition and mental health.

PI_NAMEs: ADCOCK, RACHEL ALISON (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Address;analytical method;Back;basal forebrain;Behavior;Behavioral;Blood - brain barrier anatomy;Brain;Cell Nucleus;clinical application;Cognition;Cognitive;Complement;Cues;Decision Making;Disadvantaged;Dissociation;Dopamine;Dopaminergic Agents;Education;Evolution;financial incentive;Foundations;Functional Magnetic Resonance Imaging;Goals;Grant;Hippocampus;Human;Imagery;improved;Individual;Informal Social Control;Intervention;Knowledge;learned behavior;Learning;locus ceruleus structure;Machine Learning;Measures;medial temporal lobe;Memory;Mental disorders;Mental Health;method development;Methods;Midbrain structure;Modeling;motivated behavior;Motivation;multidimensional data;multilevel analysis;neural;neural model;neural network;neurofeedback;neuroimaging;Neuromodulator;Neurons;neuroregulation;neurotransmitter release;Neurotransmitters;Norepinephrine;novel;Participant;Pattern;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Physiological;Positioning Attribute;Regulation;resilience;Resources;response;Serotonin;side effect;Signal Transduction;spatiotemporal;Specific qualifier value;Statistical Models;Stream;support network;System;Time;tool;Training;Up-Regulation;Work

PROJECT_TITLE: Bridging Scales to Understand Endogenous Neuromodulation and its Regulation

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_NAME: DANA-FARBER CANCER INST

PHR: NARRATIVE  Development of vaccines and other immunotherapies to direct cytotoxic T lymphocyte (CTL)-mediated elimination of cancers will impact global health significantly. This proposal establishes an integrative service for end users to identify those CTL targets with precision in order to harness a focused and personalized immune offensive against cancer.

PI_NAMEs: REINHERZ, ELLIS L (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Algorithms;Alkylation;Alleles;Alternative Splicing;Antigen Presentation;Antigens;Basic Science;Binding;Bioinformatics;bioinformatics pipeline;Biopsy;Biopsy Specimen;Blood capillaries;Calculi;cancer cell;cancer genome;cancer immunotherapy;CD8-Positive T-Lymphocytes;Cell surface;Cells;chemical synthesis;Chemicals;Clinical;Code;Complex;Computer software;Cysteine;Cytotoxic T-Lymphocytes;Dana-Farber Cancer Institute;Data;Data Collection;Data Files;Deposition;design;Detection;Disease;Disease remission;Epitopes;Evolution;Fine-needle biopsy;Future;Gene Fusion;Genomic Segment;Genomics;global health;HLA Antigens;HLA-A gene;Immune;immune checkpoint blockade;Immune system;Immunologic Monitoring;Immunology procedure;Immunotherapy;Individual;Industrialization;industry partner;insertion/deletion mutation;Institution;instrumentation;Ions;Liquid Chromatography;Machine Learning;Major Histocompatibility Complex;Malignant Neoplasms;Maps;Marketing;Mass Spectrum Analysis;Mediating;Messenger RNA;Methods;Minority;Modification;nanoscale;Needle biopsy procedure;neoantigens;neoplastic cell;next generation sequencing;novel;Operative Surgical Procedures;Patients;Pattern;Peptide Synthesis;Peptide/MHC Complex;Peptides;Performance;Polyadenylation;prediction algorithm;pressure;Principal Investigator;Process;Proteins;Protocols documentation;public database;Recovery;Reference Standards;Running;Sampling;Service setting;Services;Site;Surface;T-Lymphocyte;Technology;Therapeutic;Time;Tissues;transcriptome sequencing;transcriptomics;Translating;Translational Research;tumor;Untranslated RNA;Vaccination;vaccine development;web server;Western Blotting;Writing

PROJECT_TITLE: A precision tumor neoantigen identification pipeline for cytotoxic T-lymphocyte-based cancer immunotherapies


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: This research program explores molecular approaches for the study and regulation of aberrant metalloenzyme activity in human disease, focusing on the structural and chemical biology of histone deacetylase (HDAC) isozymes 6, 8, 10, and 11. HDAC6 and HDAC10 are lysine deacetylases that serve as drug targets for cancer and neurological disorders, and HDAC8 and HDAC11 are lysine-fatty acid deacylases that serve as drug targets for cancer and immune modulation. Detailed structure-function studies of these isozymes will illuminate new avenues for the design of inhibitors with improved potency and selectivity.

PI_NAMEs: CHRISTIANSON, DAVID W (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Acceleration;Active Sites;Amides;arginase;Binding;Binding Sites;Biology;Breslow Thickness;Chemical Structure;Chemicals;Chemistry;Chemotherapy-Oncologic Procedure;Clinical;Communities;Complex;Crystallization;Curiosities;Deacetylase;Deacetylation;deacylation;Dedications;Deposition;design;Development;Diagnostic;Disease;Drug Design;drug discovery;Drug Targeting;electronic structure;empowerment;enzyme activity;enzyme substrate complex;Enzymes;Exhibits;Family;Fatty Acids;FDA approved;frontier;Funding;genotoxicity;Goals;HDAC10 gene;HDAC11 gene;HDAC6 gene;HDAC8 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Histones;human disease;Hydrolysis;hydroxamate;immunoregulation;improved;inhibitor;innovation;Investigation;Ions;Isoenzymes;Lysine;Malignant Neoplasms;Manganese;Maps;metalloenzyme;Metals;Molecular;Molecular Conformation;Molecular Structure;Nervous System Disorder;Neurodegenerative Disorders;non-histone protein;novel strategies;Nuclear;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;Polyamines;Positron-Emission Tomography;Preparation;programs;Protac;protein data bank;Proteins;Regulation;Research;Safety;Side;Specificity;structural biology;Structure;Structure-Activity Relationship;Substrate Specificity;ubiquitin-protein ligase;Vorinostat;Zinc

PROJECT_TITLE: Structure and Function of Metalloenzymes

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE  Despite a high prevalence of mental health problems among refugee adults in high-income countries, there is evidence of underutilization of available mental health services. This study will leverage a mixed methods approach to explore barriers and facilitators to the utilization of mental health services over time among refugee adults in Sweden, with an emphasis on the Syrian population. Findings from this study will inform the optimization of mental health service availability for refugees and asylum-seekers in high-income countries, with implications for the integration of these populations into national health systems and host societies.

PI_NAMEs: RAYES, DIANA  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Adult;Affect;Age;Anxiety;Area;Canada;Conflict (Psychology);contextual factors;Country;Cox Proportional Hazards Models;Data;Data Analyses;data registry;design;Dimensions;disparity reduction;Distress;distrust;doctoral student;Economics;Education;Employment;Equity;Europe;evidence base;experience;Fellowship;Funding;Gender;Goals;Health;health care service utilization;Health Disparities Research;health equity;Health Professional;health service use;Health Services Accessibility;Health system;High Prevalence;improved;Income;Individual;Inequality;Inpatients;International;Interview;Language;Logistic Regressions;longitudinal analysis;marginalized population;meetings;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;Migrant;migration;Modeling;National Institute of Mental Health;natives;Natural Disasters;Neighborhoods;Outcome;Outpatients;Pattern;Personal Satisfaction;Population;population based;Post-Traumatic Stress Disorders;Poverty;Prospective Studies;Quality of life;Refugees;Registries;Reporting;Research;Research Design;Research Personnel;Research Priority;Safety;service utilization;Services;social integration;social stigma;Social Well-Being;Societies;Sweden;System;Time;Training;Transportation;Trauma;trend;Trust;Unemployment;United States;Universities;War

PROJECT_TITLE: Barriers and Facilitators to Mental Health Service Utilization Among Refugees in Sweden

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Biomedical Imaging;Chronic Pain;Pain Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative  Low back pain is the leading cause of disability globally and is closely associated with degeneration of the intervertebral discs. Recent discoveries have demonstrated the importance of the cartilage endplate in regulating disc health. The proposed work will facilitate the development of non-invasive MRI-based biomarkers measuring endplate composition, which in turn will enable fundamental insight into the etiology of disc degeneration and guide therapeutic treatments for low back pain.

PI_NAMEs: BONNHEIM, NOAH BYRON (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Address;Affect;Anatomy;Anisotropy;Area;Binding;Biochemical;Biological Assay;Biological Markers;Biological Response Modifier Therapy;Biological Sciences;Blood capillaries;Cadaver;Calibration;California;Cartilage;Cell Physiology;Cell Survival;Cells;Chronic low back pain;Clinical;Clinical Medicine;clinical translation;clinically relevant;cohort;Collagen;Data;Deterioration;Development;Diagnostic;disability;disc regeneration;Etiology;Fellowship;global health;Glycosaminoglycans;Harvest;Health;Heterogeneity;Hydration status;Image;imaging biomarker;imaging Segmentation;In Situ;In Vitro;in vivo;Individual;insight;Intervertebral disc structure;intervertebral disk degeneration;Knowledge;Location;Low Back Pain;Magic;Magnetic Resonance Imaging;Maps;mathematical model;Measurement;Measures;Microscopy;Minerals;Motion;Musculoskeletal;Natural regeneration;network architecture;novel;Nutrient;Nutritional;Orthopedic Surgery;Pain management;pain patient;Patient Selection;Patients;Pattern;Permeability;Play;Polarization Microscopy;pre-clinical;Proteoglycan;Proxy;Radiology Specialty;Relaxation;Research;Research Personnel;Role;San Francisco;Signal Transduction;Site;Spectroscopy, Fourier Transform Infrared;Spinal;spine bone structure;Statistical Models;Structure;Techniques;Testing;Therapeutic;therapy design;Time;Tissue Model;Tissues;Training;Universities;Variant;Water;Work

PROJECT_TITLE: Effects of in situ orientation on quantitative MR-based measures of cartilage endplate health


NIH_SPENDING_CATS: Diabetes;Kidney Disease;Nutrition

PHR: Project Narrative Type 2 diabetes mellitus (T2D) is one of the most common chronic diseases in the United States and is characterized by multi-organ insulin resistance and dysregulated glucose homeostasis. This project will employ novel methodologies to mechanistically understand renal insulin resistance, its pathophysiology, and the role of the kidney in perturbed whole-body glucose homeostasis in diabetes. This proposal is relevant to public health because it has the potential to inform the development of novel therapies for T2D.

PI_NAMEs: HUBBARD, BRANDON  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Alanine;American;Analytical Chemistry;blood glucose regulation;Cell membrane;cell type;Cellular biology;Chronic Disease;clinically relevant;Closure by clamp;Complex;Crystallization;Data;Defect;Development;Diabetes Mellitus;Diet;Diglycerides;experience;Fatty acid glycerol esters;feeding;Functional disorder;Gluconeogenesis;Glucose;glucose production;Glutamine;Goals;Hepatic;High Fat Diet;Homeostasis;Impairment;insight;Insulin;Insulin Receptor;Insulin Resistance;insulin signaling;interest;Isotopes;Kidney;kidney cortex;Knock-in Mouse;Learning;Lipids;Liver;Measures;Mediating;Medical;Metabolic;metabolic phenotype;Methodology;Methods;Molecular;mouse model;Mus;Mutate;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Organ;oxidation;Pathogenesis;Phosphorylation;Phosphorylation Site;Physiology;Play;protein activation;Protein Kinase;Proto-Oncogene Proteins c-akt;Public Health;Pyruvate;Role;Seminal;Signal Transduction;Techniques;Testing;Tracer;transcriptomics;United States

PROJECT_TITLE: Elucidating the pathophysiology and molecular mechanisms of renal insulin resistance


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PHR: Project Narrative The proposed research will clarify the mechanisms of memory encoding and storage in typical and atypical AD at the stage of mild cognitive impairment (MCI), as well as elucidate the specific roles of amyloid, tau, and atrophy as potential drivers of memory impairment both cross-sectionally and longitudinally. We will expand our knowledge of the mechanisms of memory impairment across the AD spectrum, with a special focus on the underserved atypical presentations of this disease, as well as clarify the mechanistic roles of and atrophy and clinical factors such as age at symptom onset to improve clinical prognostication and outcomes monitoring.

PI_NAMEs: PUTCHA, DEEPTI  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Age;Age related pathologies;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;amyloid pathology;Anatomy;Atrophic;Auditory;Behavioral;Biometry;career;cerebral atrophy;Clinical;Clinical Data;Cognitive;Cognitive deficits;cognitive testing;cohort;Communities;Data;Data Analyses;Diagnosis;diagnostic criteria;Disease;disease phenotype;disease prognosis;Dissociation;Dorsal;Episodic memory;Face;face perception;Foundations;Funding;General Hospitals;Goals;gray matter;imaging biomarker;Impaired cognition;Impairment;improved;Individual;Inferior;Investigation;Knowledge;Language;Link;Lobule;Location;Magnetic Resonance Imaging;Massachusetts;medial temporal lobe;Mediating;medical schools;Memory;memory encoding;Memory impairment;Memory Loss;Mentors;Mentorship;Methods;mild cognitive impairment;Monitor;MRI Scans;Multimodal Imaging;multimodal neuroimaging;neuroimaging;novel;Occipital lobe;Outcome;Outcome Measure;Parents;Parietal;Pathology;Performance;Population;Positron-Emission Tomography;Primary Progressive Aphasia;Process;prodromal Alzheimer's disease;prognostication;programs;Research;Resources;Retrieval;Role;semantic processing;Short-Term Memory;skills;Solid;Space Perception;Symptoms;tau aggregation;tau Proteins;Techniques;Temporal Lobe;Time;Training;United States National Institutes of Health;Variant;verbal;Visual;Work

PROJECT_TITLE: Dissociating the mechanisms of Tau PET and cortical atrophy underlying memory deficits in typical and atypical prodromal Alzheimer's disease


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Low dose computed tomography (LDCT) is a procedure recommended as a screening test for adults who have a high risk for lung cancer that has been shown to reduce lung cancer mortality. Sexual and gender minority (SGM) populations may be at higher risk for lung cancer mortality due to a higher risk of cigarette smoking. Understanding rates of LDCT screening eligibility for SGM individuals, SGM-related LDCT screening disparities, and modifiable factors for such disparities can inform efforts to reduce morbidity and mortality caused by cigarette smoking, such as lung cancer and other lung-related conditions.

PI_NAMEs: ENGSTROM, CURTISS WAYNE (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Accounting;Address;Adult;Advisory Committees;Age;aged;Aging;Attitude;Behavior;Behavioral Risk Factor Surveillance System;cancer diagnosis;Cessation of life;cigarette smoking;cisgender;combustible cigarette;Communities;Complex;computed tomography screening;Cross-Sectional Studies;Data;Data Collection;Data Set;Data Sources;Disparity;Drug usage;Eligibility Determination;Equation;experience;Fellowship;Gender;Gender Identity;gender minority group;Guidelines;Health;Health behavior and outcomes;Health Surveys;Heterosexuals;high risk;improved;Incidence;Individual;Individual National Research Service Award;interest;Knowledge;knowledge base;Lesbian Gay Bisexual Transgender;Longitudinal cohort;low dose computed tomography;Lung;Malignant neoplasm of lung;Measurement;Measures;Mentors;Mentorship;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;multiple data sources;multiple datasets;National Health Interview Survey;Nicotine;novel;Outcome;Paper;peer;Persons;Policies;Population;Population Assessment of Tobacco and Health;pre-doctoral;Prevalence;preventable death;Preventive service;primary outcome;Probability;Procedures;psychological distress;Psychological Stress;Public Health;Qualifying;Recommendation;Reporting;Research;Risk;Risk Factors;Risk Reduction;Sample Size;Sampling;screening;screening disparities;Sexual and Gender Minorities;sexual identity;sexual minority;sexual minority group;sexual minority health;sexual minority health disparity;Sexuality;skill acquisition;Smoke;Smoker;Smoking;Smoking Behavior;Smoking History;social;Subgroup;Survey Methodology;Surveys;Techniques;Testing;Time;Tobacco;Tobacco smoking behavior;Tobacco use;Training;transgender;trend;United States;Urbanicity;Weight;Work

PROJECT_TITLE: Low Dose Computed Tomography (LDCT) Eligibility and Outcome differences between Sexual and Gender Minorities and their Sexual and Gender Majority Counterparts


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE The proposed studies are relevant to public health because they have the potential to identify women at high risk of breast cancer using ethnic-specific models. Thus, this advance is expected to have a high impact to the health and well being of women because women at high risk may choose to alter the breast cancer screening frequency for earlier detection or to participate in risk reduction strategies, such as lifestyle modification. Both approaches will reduce breast cancer mortality. This is relevant to the part of NIH's mission which focuses on the prevention of disease by supporting research in the prevention and early detection of human diseases.

PI_NAMEs: KERLIKOWSKE, KARLA M;SHEPHERD, JOHN ALAN (contact)

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: 3-Dimensional;Address;Adult;advanced breast cancer;Advanced Malignant Neoplasm;American Samoa;Artificial Intelligence;artificial intelligence model;Asian;Asian Americans;Asian population;Asian Women;Biological Markers;Black race;black women;Body mass index;Breast;Breast biopsy;Breast Cancer Detection;Breast Cancer Risk Factor;breast density;breast imaging;calcification;California;Cancer Center;cancer invasiveness;cancer risk;Characteristics;Chinese;Clinic;Clinical;clinical risk;Clinical Trials;cohort;Data;data registry;Databases;density;digital;disorder prevention;Early Diagnosis;Early treatment;ethnic difference;ethnic diversity;Ethnic Origin;Ethnic Population;experience;Family history of;Filipino;Frequencies;Goals;Guam;Hawaii;Health;high risk;High Risk Woman;Hispanic Women;human disease;Image;imaging biomarker;improved;improved outcome;Incidence;Japan;Japanese;Japanese American;Life Style Modification;Machine Learning;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;mammography registry;Measures;member;Mission;Modeling;Morbidity - disease rate;mortality;Native Hawaiian;Native Hawaiian or Other Pacific Islander;next generation;Not Hispanic or Latino;novel;Obesity;Pacific Islander;Pacific Islands;Pattern;Personal Satisfaction;Population;Population Heterogeneity;Population Study;Positioning Attribute;Prevalence;Prevention;programs;Public Health;racial difference;racial population;radiomics;Recording of previous events;Registries;reproductive;Research Personnel;Research Support;Resources;Risk;Risk Factors;risk prediction;Risk Reduction;Sampling;San Francisco;screening;Testing;Texture;tumor registry;United States National Institutes of Health;Universities;Weight Gain;White Women;Woman;women's morbidity;Women's mortality;women's outcomes

PROJECT_TITLE: Hawaii Pacific Islands Mammography Registry

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: SAN MARCOS

ORG_NAME: CALIFORNIA STATE UNIVERSITY SAN MARCOS

PHR: Project Narrative The goal of this project is to reduce health disparities among Latinos and Native Hawaiians and Pacific Islanders (NHPI), especially considering new health behavior patterns, social norms, and increased technology use related to the COVID-19 pandemic. Through Community-based Participatory Research (CBPR), we will partner with Latino and NHPI communities to co-design and develop new technology, an mHealth application for smartphones, to improve the health concerns identified by the communities (e.g., obesity-related health behaviors and mental health). This project also focuses on training students from underrepresented in biomedical research in all phases of the research and innovation development, with an emphasis on training future, independent health disparities researchers and scholars.

PI_NAMEs: HOLUB, CHRISTINA KIM (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Address;Attitude;Behavior Therapy;Belief;Biomedical Research;Businesses;Cause of Death;Collaborations;Communities;community advisory board;community based participatory research;Community Health;community partners;Computer software;COVID-19;COVID-19 pandemic;Data;demographics;design;Development;Diabetes Mellitus;Discipline of Nursing;Education;Engineering;Ensure;experience;Faculty;Feedback;Focus Groups;Foundations;Funding;Future;Goals;graduate school;graduate student;Habits;Health;Health behavior;Health behavior and outcomes;Health Disparities Research;health disparity;Health Promotion;Health Sciences;Heart Diseases;Human Development;improved;informant;information gathering;innovation;insight;Interdisciplinary Study;Interview;Kinesiology;Knowledge;Language;Latino;Latino Population;Life;Malignant Neoplasms;member;Mental Health;mHealth;Minority Groups;Mobile Health Application;Native Hawaiian or Other Pacific Islander;new technology;Obesity;Outcome;pandemic disease;pandemic impact;Paper;Participant;Pattern;Phase;Population;posters;preference;Public Health Students;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Support;response;Risk Behaviors;satisfaction;Science;Series;Small Business Technology Transfer Research;smartphone application;social;social norm;STEM field;Student recruitment;student training;Students;success;Surveys;Technology;Testing;Training;Trust;Uncertainty;undergraduate student;Underrepresented Students;underserved community;Underserved Population;usability;willingness;Work

PROJECT_TITLE: Designing Technology to Facilitate Participation in Health Behavior Interventions among Underserved Populations: A CBPR Approach to Reduce Health Disparities and Address Changing Norms since COVID-19


NIH_SPENDING_CATS: Estrogen;Genetics

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Our data suggest that acute signal or ligand-dependent activation of target enhancers causes them to form an RNA-protein condensate, with features of phase separation, resulting in in induced proximity and cooperative activation of other homotypic enhancers, although separated by multiple TADs and, potentially, even in other chromosomes. In contrast, chronic signal/ligand activation results in loss of the dynamic RNP condensate at the enhancers, loss of induced proximity of homotypic enhancers observed with acute activation, with enhancer activation function now confined to the nearby cognate target gene promoters. We will use global genomic, proteomic, and real time, single nucleus approaches with the goal of providing a paradigm-shifting insight into hormone-regulated transcriptional programs.

PI_NAMEs: ROSENFELD, MICHAEL G (contact)

PROJECT_TERMS: Acute;Architecture;Binding;Breast;Cell Differentiation process;Cell Line;Cell Nucleus;Cells;Cellular biology;Chemicals;Chromatin;Chromosomes;Chronic;cohort;Complex;condensin;Data;DNA;DNA Damage;Enhancers;ESR1 gene;Estradiol;Estrogens;Event;Exhibits;Gel;Gene Activation;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genome-wide;Genomic approach;Genomics;Goals;Grant;heterochromatin-specific nonhistone chromosomal protein HP-1;high resolution imaging;Hormones;Human;Informatics;insight;interdisciplinary approach;Investigation;Knowledge;Ligands;Link;MALAT1 gene;Mammalian Cell;Mediating;Mediator;Methods;Modeling;Modification;Molecular;Molecular Conformation;molecular imaging;Movement;N-terminal;Nature;Neurosecretory Systems;Nuclear;Nuclear Receptors;Outcome;Pattern;Phase;Physical condensation;Physiological;Play;programs;promoter;Property;Proteins;Proteomics;real-time images;recruit;Resistance;response;Ribonucleoproteins;RNA;Role;Signal Induction;Signal Transduction;single molecule;Specificity;Structure;Technology;Testing;Time;Topoisomerase;Transcriptional Activation;Transcriptional Regulation;virtual;Visualization

PROJECT_TITLE: Phase Separation: A New Phase in Decoding Enhancer-dependent Critical Transcriptional Programs by Nuclear Receptors

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence

ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Atrial fibrillation is an increasingly prevalent cardiac arrhythmia in the United States and a leading cause of stroke. Current treatments for atrial fibrillation are often ineffective and could have significant side effects. In this study, we will conduct a comprehensive and integrated study to unveil the distinguishing fingerprints of atrial fibrillation substrates in order to develop new personalized therapies that successfully define, target, and treat the sources of atrial fibrillation in the human heart.

PI_NAMEs: FEDOROV, VADIM V (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: 3-Dimensional;Ablation;Affect;Age;aging population;Animals;Arrhythmia;Atrial Fibrillation;Automobile Driving;bench to bedside;canine model;Cells;Characteristics;Clinical;clinical imaging;Clinical Research;comorbidity;Complex;Computer Models;contrast enhanced;Data;Development;Diabetes Mellitus;Disease;Electrodes;extracellular;Extracellular Matrix;Fibroblasts;Fibrosis;Fingerprint;Functional impairment;Funding;Genes;Genetic Fingerprintings;Goals;Heart;Heart Atrium;Heart failure;Heart Research;Histology;Hospitalization;Human;Hypertension;Image;imaging approach;in vivo;Individual;Inflammatory;Left;Machine Learning;machine learning algorithm;Macrophage;Magnetic Resonance Imaging;Maps;Microanatomy;Modeling;Molecular;Molecular Genetics;Molecular Profiling;Morbidity - disease rate;Multimodal Imaging;multimodality;novel;Obesity;Optics;Patients;periostin;personalized medicine;PET/CT scan;pharmacologic;Positron-Emission Tomography;pre-clinical;programs;Proteins;Publishing;Recording of previous events;Research;Resolution;Right atrial structure;Risk Factors;Role;sex;side effect;Signal Pathway;Source;Stroke;Structure;Surface;Technology;Testing;Therapeutic Intervention;three dimensional structure;Three-Dimensional Imaging;Training;transcriptomics;translational framework;translational pipeline;Translational Research;translational study;United States;Validation;X-Ray Computed Tomography

PROJECT_TITLE: Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: PROVIDENCE

ORG_NAME: OCEAN STATE RESEARCH INSTITUTE, INC.

ORG_STATE: RI

PHR: PROJECT NARRATIVE Current treatments for depression and anxiety are limited by modest efficacy and significant side effects, and these disorders are a serious threat to public health and burden of illness and contribute to increasing rates of suicide. This application proposes the critical first-in-human research to develop a new kind of intervention, called low intensity focused ultrasound, for people suffering from depression and anxiety. Using acoustic energy, this study will serve to characterize brain targets to engage and provide unique insights into the future best practices for rationally designed clinical trials.

PI_NAMEs: PHILIP, NOAH STEPHEN (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acoustics;Acute;Address;Amygdaloid structure;Anatomy;Anxiety;Anxiety Disorders;Brain;Brain region;burden of illness;Cephalic;Clinical;Clinical Trials;Clinical Trials Design;Contralateral;Controlled Study;Crossover Design;Data;Depressive disorder;design;Detection;Devices;Diagnostic;Disease;Distal;effective therapy;Electric Stimulation;Electromagnetics;Emotional;Emotions;Evaluation;experience;Experimental Designs;experimental study;Face;Family suidae;first-in-human;Focused Ultrasound;follow-up;Functional Magnetic Resonance Imaging;Future;Grant;Human;improved;Individual;insight;interest;Intervention;Left;Magnetic Resonance Imaging;Magnetism;Major Depressive Disorder;Measures;Mental Depression;Modeling;Motor Cortex;Mus;neural;Neurologic;nonhuman primate;noninvasive brain stimulation;Obsessive-Compulsive Disorder;Oryctolagus cuniculus;Outcome;Participant;Pathologic;Patients;Persons;Physiologic pulse;Post-Traumatic Stress Disorders;Public Health;Pulsar;Randomized;rational design;recruit;Research;Research Design;Risk;Role;Safety;safety assessment;safety testing;side effect;Somatosensory Cortex;Sonication;Specificity;Structure;suicidal risk;suicide rate;Surface;symptomatic improvement;Symptoms;System;Technology;Testing;Thalamic structure;translational model;ultrasound;Writing

PROJECT_TITLE: Low intensity focused ultrasound: a new paradigm for depression and anxiety


PHR: PROJECT NARRATIVE Atherosclerosis begins when low density lipoproteins (LDL) enter the vessel wall and are retained. Our data show high density lipoproteins (HDL) can inhibit LDL entry and retention. As such, this study aims to define how the balance between LDL and HDL influence plaque buildup in the artery wall and how it is altered in type 2 diabetes.

PI_NAMEs: DAVIDSON, W SEAN;SHAH, AMY SANGHAVI (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Adolescent;Adult;Affect;Age;Animal Model;Animals;Arteries;atherogenesis;Atherosclerosis;Binding;Biological Assay;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cells;Cessation of life;cohort;Data;Endothelial Cells;Endothelium;Equilibrium;Event;Exhibits;extracellular;Family;feasibility testing;Functional disorder;Future;high density lipoprotein receptor;High Density Lipoproteins;high risk;Human;In Vitro;Individual;insight;K-Series Research Career Programs;LDL Cholesterol Lipoproteins;life span;lipidomics;Lipids;Lipoprotein Binding;Lipoproteins;Low-Density Lipoproteins;Mediating;Mus;Non-Insulin-Dependent Diabetes Mellitus;particle;Patients;peptidomimetics;Persons;Plasma;Population;premature;prevent;Process;Proteins;Proteoglycan;Proteomics;Recombinants;Regulation;Role;Sampling;Series;Specimen;SR-BI receptor;Surface Plasmon Resonance;Testing;Therapeutic;transcytosis;Vascular Endothelium;Work;Youth

PROJECT_TITLE: Lipoprotein Interactions in the Vessel Wall

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Data Science;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Sleep Research

PHR: PROJECT NARRATIVE Stress has a central role in mental health conditions and improved understanding of how stress affects brain and body could deliver great potential clinical impact. To determine the brain and body responses to varying stressors we will use novel instrumentation to measure 50+ behavioral metrics at sub-second resolution together with multi-brain site electrophysiology over weeks. We will then determine how varying stressors affect circadian and broader changes across animal behavior and physiology as well as neural circuit dynamics.

PI_NAMEs: WATSON, BRENDON O (contact)

PROJECT_TERMS: actigraphy;Addictive Behavior;Address;Affect;analytical method;Anhedonia;Animal Behavior;anti-depressive agents;Anxiety Disorders;Autopsy;Behavior;behavior measurement;Behavior monitoring;Behavioral;behavioral phenotyping;Big Data;biological adaptation to stress;Biological Markers;Biology;Body Temperature;Brain;Brain imaging;Brain region;Chronic;Chronic stress;circadian;Circadian Rhythms;Clinical;Code;Communication;Coupled;Coupling;Data;Data Science;data structure;Decision Making;Diet Habits;digital;digital measure;Dimensions;Dose;Eating;Electrophysiology (science);Elements;Equilibrium;field study;forced swim test;forging;Foundations;Future;Goals;Grooming;hands-on learning;Hippocampus;Histologic;Home;Human;Implant;improved;innovation;insight;instrumentation;Intervention;Ketamine;Knowledge;large datasets;Libraries;Link;Machine Learning;machine learning method;Major Depressive Disorder;Measures;Medial;Mediating;Mental disorders;Mental Health;Molecular;Monitor;Moods;Mus;Nature;neural;neural circuit;neural network;Neurobiology;neuroregulation;Neurosciences;novel;Nucleus Accumbens;Phenotype;Physiological;Physiology;Play;Predictive Analytics;preference;Prefrontal Cortex;Process;Psychological Stress;Recovery;REM Sleep;Resolution;response;Response Elements;Rodent;Role;Site;Sleep;Sleep Deprivation;Solid;Stress;stress reduction;stressor;Structure;Substance Use Disorder;Sucrose;Synapses;System;Techniques;Testing;Time;transmission process;Work

PROJECT_TITLE: Digital behavioral phenotyping and multi-region electrophysiology to determine behavioral and neural network changes underlying the stress response in mice


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Activity

PHR: PROJECT NARRATIVE The research described in this proposal aims to investigate the rejuvenating and therapeutic effects of circulating platelet factors on the aged brain. These studies will have significant translational potential, identifying circulating platelet-derived factors as candidate therapeutic targets to restore age-related cognitive dysfunction and potentially treat dementia-related neurodegenerative disorders such as Alzheimer’s disease.

PI_NAMEs: VILLEDA, SAUL A (contact);WALKER, TARA

PROJECT_TERMS: Adult;adult neurogenesis;age related;age related neurodegeneration;age related neuroinflammation;age-related disease;aged;aging brain;aging hippocampus;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;animal old age;anti aging;Attenuated;behavior test;Biological Assay;Blood;Blood - brain barrier anatomy;Blood Platelets;Brain;Cardiovascular system;Cells;chemokine;Circulation;Coagulation Process;Cognition;Cognitive;cognitive benefits;cognitive function;Data;Dementia;Disease;Elderly;Exercise;Exposure to;glial activation;Hippocampus;Human;Immune;immunoregulation;Impaired cognition;improved;In Vitro;in vivo;Incidence;insight;juvenile animal;Learning;Mass Spectrum Analysis;Mediating;Memory;memory process;Microglia;Molecular;mouse model;Mus;Neurodegenerative Disorders;neurodegenerative phenotype;neurogenesis;neuroinflammation;new therapeutic target;novel therapeutics;old mice;Parabiosis;Pathway interactions;Peripheral;PF4 Gene;Plasma;Population;programs;Proteomics;regenerative;Regenerative capacity;Regulation;Rejuvenation;Research;Role;single-cell RNA sequencing;systemic intervention;Testing;theories;Therapeutic;therapeutic candidate;Therapeutic Effect;therapeutic target;trafficking;translational potential

PROJECT_TITLE: Systemic Mechanisms of Brain Rejuvenation


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Microglial inflammation has been implicated in the pathology of numerous neurodegenerative diseases, neurodevelopmental disorders, and other neurological conditions, and suppressing the activation of innate immune signaling pathways in these cells could thus represent a broad therapeutic approach. To enhance the efficacy and safety of such an approach, the intervention should be both long-term and targeted to microglia, such that a gene therapy based on an adeno- associated viral (AAV) vector would be promising. Since natural AAVs exhibit inefficient, non-targeted delivery to human microglia, however, we propose to integrate directed evolution of AAV with molecular barcoding, single cell next generation sequencing (NGS), machine learning, and human tissue and non-human primate (NHP) brain models to develop AAVs for selective gene delivery of potential therapeutic cargoes to primate microglia.

PI_NAMEs: NOWAKOWSKI, TOMASZ ;SCHAFFER, DAVID V (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: adeno-associated viral vector;Adult;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;ATAC-seq;autism spectrum disorder;Bar Codes;Binding Sites;Biology;Biomedical Engineering;Brain;Capsid;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Chronic;Clinical Trials;Collaborations;Complement;Data;Directed Molecular Evolution;Disease;Down's Syndrome;efficacy validation;Engineering;Enhancers;Exhibits;experience;Future;Gene Delivery;Gene Expression;gene therapy;Genes;genetic manipulation;genome editing;Genomics;high risk;Human;human disease;human tissue;Huntington Disease;Immune signaling;immunoregulation;Immunosuppression;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Injections;innovation;insight;Intervention;Intravenous;knock-down;Libraries;Machine Learning;Mediating;Metallothionein;Methods;Microglia;Modeling;Molecular;mouse model;multidisciplinary;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurologic;Neurons;Neurosciences;next generation sequencing;NF-kappa B;nonhuman primate;novel;overexpression;painful neuropathy;Parkinson Disease;Pathology;Primates;programs;promoter;receptor;Regulatory Element;Research;Role;Safety;selective expression;Signal Pathway;Signal Transduction;single cell analysis;single cell sequencing;Slice;Specificity;Surface;System;Technology;technology development;technology platform;Therapeutic;therapeutic gene;Tissues;tool;trafficking;transcription factor;Variant;vector;Viral;Viral Vector;Work

PROJECT_TITLE: Directed Evolution of Novel AAVs and Regulatory Elements for Selective Microglial Gene Expression

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Aging;Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Deficits in motivation are disabling features of numerous neuropsychiatric disorders including Parkinson’s disease, but a lack of understanding of dysfunction in human reward circuits prevents the development of effective treatments for these conditions. The goal of this project is to use novel sensing-enabled deep brain stimulation devices and computational reward learning models to identify the neural circuits underlying healthy and unhealthy goal-directed decision-making, as well as to test their causal role in behavior via closed-loop neurostimulation. Delineating the neural mechanisms of goal-directed decision-making in humans will uncover fundamental neurobiology of reward processing and provide biomarkers that can optimize the diagnosis, treatment, and prevention of motivation dysfunction in Parkinson’s disease and other neuropsychiatric disorders.

PI_NAMEs: HOY, COLIN  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Applications Grants;Automobile Driving;Basal Ganglia;Behavior;Behavior Disorders;Behavioral Research;Biological Markers;Brain;Brain imaging;career;Choice Behavior;Choices and Control;Chronic;Clinical;Cognitive deficits;cohort;Communication;Computer Models;Conflict (Psychology);Decision Making;Deep Brain Stimulation;design;Development;Devices;Diagnosis;Disabling;Dopaminergic Agents;Economic Burden;effective therapy;Electrocorticogram;Electrophysiology (science);Ethics;Evaluation;Evolution;experimental study;Feedback;Fellowship;Frequencies;frontal lobe;Functional disorder;Future;Globus Pallidus;Goals;Home;Human;imaging study;implantable device;Impulsivity;indexing;Individual;innovation;K-Series Research Career Programs;Knowledge;Learning;Link;Measures;Mental disorders;Mentors;Modeling;Motivation;Motor;Motor Cortex;motor symptom;Nervous System Disorder;neural;neural circuit;neural network;Neurobiology;neuroethics;neuromechanism;neurophysiology;neuropsychiatric disorder;neuropsychiatry;Neurosciences;neurotechnology;neurotransmission;non-motor symptom;novel;novel therapeutics;Parkinson Disease;Pathology;Patients;Persons;Pharmaceutical Preparations;Population;precision neuromodulation;Prefrontal Cortex;prevent;Prevention;Psychological reinforcement;Quality of life;Reporting;Research;Research Personnel;reward processing;Rewards;Role;secondary analysis;Signal Transduction;Site;Structure;Structure of subthalamic nucleus;Symptoms;System;targeted treatment;Testing;therapy development;Training;Work

PROJECT_TITLE: Identifying the neural mechanisms of goal-directed decision-making in Parkinson's disease using closed-loop deep brain stimulation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Complementary and Integrative Health;Dementia;Epilepsy;Mental Health;Neurodegenerative;Neurosciences;Nutrition;Prevention;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The aging brain is vulnerable due to many changes including mitochondrial dysfunction, increased inflammation, insulin resistance and decreased neurotransmitter release leading to poor sleep quality and more complications with general anesthesia. This project aims to develop metabolic interventions (increasing ketones) to alleviate the metabolic-immune dysregulation that occurs in the aging brain to improve sleep and general anesthesia safety in the elderly and eventually to treat neurodegenerative diseases like Alzheimer's disease.

PI_NAMEs: NEHS, CHRISTA JOY (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acetoacetates;Acetylcholine;Address;Adenosine;Age;age related decline;aged;Aging;aging brain;aging population;Alzheimer's Disease;Alzheimer’s disease biomarker;Anesthesia procedures;Anesthetics;animal old age;Animals;antagonist;Antiinflammatory Effect;Anxiety;autism spectrum disorder;beta-Hydroxybutyrate;Biosensor;Blood;Brain;Brain Diseases;brain health;brain metabolism;Carbohydrates;Clinical;Dementia;Diet;early detection biomarkers;Eating;Elderly;Electroencephalography;Epilepsy;Exercise;experimental study;Fatty acid glycerol esters;Fatty Acids;gamma-Aminobutyric Acid;General Anesthesia;General anesthetic drugs;Glioblastoma;Glucose;Glutamates;IL17 gene;Immune;Impaired cognition;improved;improvement on sleep;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;innovation;Insulin Resistance;Interleukin-1;Interleukin-10;Interleukin-6;Intervention;ketogenic diet;Ketone Bodies;Ketones;Link;liquid chromatography mass spectrometry;Measures;Mental Depression;Metabolic;metabolomics;Methods;Microdialysis;Mitochondria;mitochondrial dysfunction;neurocognitive disorder;Neurodegenerative Disorders;Neuromodulator;neuronal metabolism;Neurons;neuroprotection;neurotransmitter release;new therapeutic target;NF-kappa B;non rapid eye movement;Norepinephrine;normal aging;novel strategies;Older Population;Parkinson Disease;Pathway interactions;poor sleep;post-operative cognitive dysfunction;postoperative delirium;Predisposition;Prefrontal Cortex;Propofol;Purinergic P1 Receptors;Pyruvate;Rattus;Reactive Oxygen Species;REM Sleep;Research;Rodent;Safety;Seizures;sevoflurane;Signal Transduction;Sleep;Sleep disturbances;Sleep Fragmentations;sleep quality;Source;Starvation;Testing;Time;TNF gene;Weight

PROJECT_TITLE: Metabolic Interventions for Sleep, Anesthesia-related Neurocognitive Disorders and Alzheimer's Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]