NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Telehealth

ORG_CITY: Laguna Woods

ORG_NAME: NEUROCOMP SYSTEMS, INC.

PHR: PROJECT NARRATIVE The rationale for remote neurocognitive assessment include addressing the needs of underserved populations, reducing the risk of exposure to infective disorders, rapid care access, and minimizing travel burden to distal clinical centers. A Computerized Assessment by Remote Examiner System (CARES) is proposed that will integrate a range of system functions, including end-to-end study/trial monitoring and management services ranging from user registration to reporting. CARES will host computerized versions of neurocognitive and behavioral tests widely applied in clinical assessment, controlled trials and wide-ranging research. The CARES constitutes a key enabling technology for assessing those with AD/RD and early stage MCI.

PI_NAMEs: O'HALLORAN, JAMES P (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Address;Advisory Committees;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease test;Android;Architecture;authority;Behavior assessment;behavior test;Certification;Clinical;Clinical assessments;clinical center;Clinical Trials;cognitive function;Communication;computerized;cost;COVID-19;dashboard;Data;data management;Databases;design;Devices;Diagnosis;digital;Disease;Distal;Elderly;Electronics;Evaluation;Exposure to;follow-up;Goals;Health Services Accessibility;Home;Human;Hybrids;Impaired cognition;indexing;Infrastructure;Instruction;instrument;Internet;Language;Manuals;mobile computing;Modality;Monitor;Mus;Natural Language Processing;Neurocognitive;neurocognitive test;next generation;nonEnglish language;Operating System;Paper;Participant;patient response;Patients;peer;Perception;Persons;Phase;phase 1 testing;Population;Portal System;Procedures;Process;prototype;Recommendation;Reference Standards;remote administration;remote assessment;Reporting;Research;research clinical testing;research study;response;Risk Reduction;Sample Size;Sampling;Services;Site;software development;Specific qualifier value;symposium;System;Technology Assessment;Telephone;telephone based;Testing;Touch sensation;Trail Making Test;Training Activity;Travel;Underserved Population;usability;Validation;Variant;verbal;virtual;Voice

PROJECT_TITLE: Assessment Validation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-C(10)B]


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: WORCESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

ORG_STATE: MA

PHR: The goals of this proposal are very directly aligned with the goals identified in the NIBIB’s Strategic Plan for Research and relevant to unmet public health needs. Specifically: Goal 1: Develop innovative biomedical technologies that integrate engineering with the physical and life sciences to solve complex problems and improve health. Our work will lead to faster, more accurate, patient-tailored evaluation of brain function, accelerating the diagnosis of neural pathologies, and enabling

PI_NAMEs: MAKAROFF, SERGEY N (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Acceleration;Address;Affect;Algorithms;analysis pipeline;Anatomy;anti-depressive agents;Anxiety;Area;Biological Sciences;Biomedical Technology;Boundary Elements;Brain;Charge;cognitive neuroscience;Complex;Computer software;Coupling;Data;density;design;Development;Diagnosis;Disease;Documentation;Dryness;electric field;Electrodes;Electroencephalography;Engineering;Evaluation;experimental study;Feeling suicidal;finger movement;Fingers;Finland;Germany;Goals;gray matter;Head;Health;health assessment;Human Activities;improved;indexing;innovation;insight;Institution;International;Language;Location;Lymphocytic choriomeningitis virus;magnetic resonance imaging/electroencephalography;Measurement;Measures;median nerve;Mental Depression;Mental Health;Methods;Modality;Modeling;Motivation;Motor;National Institute of Biomedical Imaging and Bioengineering;neural;neuroimaging;Neurons;Pathologic;Pathology;patient response;Patients;physical science;Population;Problem Solving;Public Health;Pythons;reconstruction;Reporting;Research;Resolution;response;Schools;somatosensory;Source;source localization;speech processing;Speed;Strategic Planning;Students;Surface;System;Technology;Thumb structure;Time;tool;undergraduate student;Universities;verification and validation;volunteer;Well in self;Work;young adult;Youth

PROJECT_TITLE: CRSNS: Development of EEG/MEG Source Reconstruction with Fast Multipole Method

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(50)R]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Physical Activity;Prevention

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative While there are many important health benefits of physical activity, how exercise exerts its effects is not fully understood. A more comprehensive understanding of the molecular mechanisms underlying the responses to exercise would significantly impact public health. Continuation of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) will achieve its objective of generating a comprehensive map of the molecular responses to acute exercise and exercise training. with a long-range goal of elucidating the mechanisms by which exercise improves health.

PI_NAMEs: ESSER, KARYN A;MILLER, MICHAEL E. (contact);REJESKI, WALTER JOHN;STOWE, CINDY ;TRACY, RUSSELL P

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Acute;Adherence;analytical method;Ancillary Study;Animals;Attention;Award;Bioinformatics;Biological;Biological Process;Biological Specimen Banks;biological systems;Certification;Chemicals;Chronic;Clinic;clinical center;Clinical Data;Clinical Distribution;Clinical Management;clinical research site;Clinical Trials Data Monitoring Committees;Collaborations;Collection;Communication;Communities;Data;data management;data sharing;design;Development;development policy;Disease Outcome;Documentation;endurance exercise;Ensure;Exercise;exercise intervention;exercise training;experience;Florida;Fostering;Funding;Future;Goals;Health;Health Benefit;Health system;Human Resources;improved;Information Technology;innovation;Institutional Review Boards;Intervention;Knowledge;Lead;Leadership;Manuals;Maps;Measures;medical schools;meetings;Molecular;Monitor;Multi-Institutional Clinical Trial;Multi-site clinical study;multidisciplinary;multiple omics;Online Systems;Organization and Administration;participant retention;Pathway interactions;Patient Recruitments;Phenotype;phenotypic data;Physical activity;pre-clinical;Procedures;Process;Progress Reports;Protocols documentation;Public Health;Publications;Publishing;Qualifying;Quality Control;Randomized;Recording of previous events;recruit;Reporting;Reproducibility;Research;Research Design;Research Personnel;resistance exercise;Resource Sharing;Resources;response;Safety;Sampling;Schedule;Science;Shipping;Site;Site Visit;Standardization;Structure;success;synergism;Technology;Time;Tissues;tool;Training;Transducers;United States National Institutes of Health;Universities;Vermont;working group

PROJECT_TITLE: Molecular Transducers of Physical Activity Consortium Coordinating Center


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Mapping the function of every gene in human cells will enable us to begin to define how gene expression programs impart specialized and adaptive human cellular functions required for life. The innovative approach proposed here combines CRISPRoff, a cutting-edge genetic manipulation technology, with comprehensive single cell molecular phenotyping approaches in a classic model of human development, which will allow us to study the effects of specific genes in a biologically meaningful way to yield new insights that are broadly applicable across cell types and disease areas. Specifically, we will characterize at single cell resolution in space and time the function of human transcription factors and epigenetic regulators in early developmental cell fate transitions.

PI_NAMEs: GILBERT, LUKE  (contact)

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Alleles;Applied Genetics;Area;ATAC-seq;Biological Assay;Biological Models;Biology;biomedical scientist;Cell division;Cell model;Cell Physiology;cell type;Cells;Cellular biology;Chimeric Proteins;Chromatin;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communities;Compensation;Development;Disease;DNA Damage;DNA Methylation;DNA Repair;Ectoderm;Embryoid bodies;Embryonic Development;Endoderm;epigenetic memory;Epigenetic Process;functional genomics;Gene Expression;gene function;Gene Silencing;Genes;Genetic;genetic manipulation;Genetic Transcription;Genomic approach;Goals;Histones;Human;Human Biology;Human Development;human disease;Human Genome;human model;Image;Individual;induced pluripotent stem cell;innovation;insight;interest;Life;Maps;Measures;Mesoderm;Messenger RNA;Methods;Microscopy;Modeling;Molecular;molecular phenotype;multiple omics;Mutagenesis;Neurons;Nuclear;Organoids;paralogous gene;Phenotype;Population;Process;programs;Proteins;Reproducibility;Research;Research Personnel;resilience;Resolution;Resources;single cell ATAC-seq;single-cell RNA sequencing;Specificity;stem cell differentiation;stem cells;Technology;Testing;Time;transcription factor;transcriptome;transcriptomics

PROJECT_TITLE: Spatial multiomic mapping of gene function with CRISPRoff


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The fusion peptide of HIV-1 is a vulnerable target site with tremendous promise for new preventions and treatments. This project applies recently established technologies to understand how antibodies against the fusion peptide effectively suppress HIV-1. This study will reveal new best-in-class antibody drugs against the fusion peptide site and provide actionable vaccine strategies to help end the HIV-1 pandemic.

PI_NAMEs: DEKOSKY, BRANDON JAMES (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Acceleration;Address;Affinity;Antibodies;antibody engineering;antibody libraries;Antibody Response;antibody test;Antibody Therapy;Antigens;antiretroviral therapy;Apical;B-Lymphocytes;Binding;Binding Sites;Biophysics;Cells;chronic infection;Clinical;clinically relevant;Complement 1q;cost;cross reactivity;Data;Development;Directed Molecular Evolution;Drug Design;Engineering;Epitopes;Exposure to;Fab domain;Genetic;Genetic Variation;global health;Goals;HIV;HIV Antigens;HIV-1;Immune;Immunoglobulin Somatic Hypermutation;Immunosuppression;improved;Individual;Infection;Infection prevention;innovation;insight;Interruption;Intervention;invention;Knowledge;Laboratories;Learning;Libraries;Maps;Mediating;Membrane;Mining;Molecular;Monoclonal Antibodies;Mutation;mutation screening;neutralizing antibody;non-Native;Outcome;pandemic disease;Pathway interactions;Peptide antibodies;peptide vaccination;Peptide Vaccines;Peptides;Performance;Pharmaceutical Preparations;prevent;Prevention;Proteins;Protocols documentation;recruit;Resources;response;screening;Site;synergism;Techniques;Technology;Therapeutic;therapeutic development;transmission blocking;transmission process;Vaccination;Vaccine Antigen;Vaccine Design;vaccine development;vaccine strategy;Vaccines;Variant;Viral;viral rebound;Yeasts

PROJECT_TITLE: Potent broadly neutralizing antibody development against the HIV-1 fusion peptide epitope

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Health Relevance All drugs of abuse cause levels of the neurotransmitter dopamine to be elevated in the nucleus accumbens. This effect is considered critical to the addictive and psychomotor activating properties of abused drugs, as well as to the arousing effects of psychostimulants, but the specific neural mechanisms at play remain enigmatic in part because the natural functions of accumbens dopamine are poorly understood. By determining how dopamine alters the activity of accumbens neurons to promote both arousal and reward-seeking behavior, we will open a new path towards understanding how the elevated dopamine caused by drugs leads to the behavioral consequences of taking these drugs, which may ultimately lead to novel therapeutics to treat addiction.

PI_NAMEs: NICOLA, SALEEM M (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TITLE: Nucleus accumbens processing of reward-predictive cues

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: Alameda

ORG_NAME: MAGNETIC INSIGHT, INC.

PHR: NARRATIVE Despite the importance of medical imaging in modern clinical diagnosis and treatment, current techniques struggle in essential areas such as monitoring newly developed cell-based therapies, detecting diseases of inflammation, and quantitatively detecting bleeding. Magnetic Particle Imaging (MPI) is an emerging medical imaging technology that provides scientists and clinicians with a new tool for understanding, diagnosing, and monitoring these pathologies. In this Direct-to-Phase II SBIR grant, we will develop critical technologies to bring the sensitivity and resolution of the world’s first human-scale MPI scanner near the physics limits, marking a significant step forward on the path to a commercial clinical MPI scanner.

PI_NAMEs: GOODWILL, PATRICK  (contact)

PROGRAM_OFFICER_NAME: ASHMONT, KARI RICH

PROJECT_TERMS: Air;Amplifiers;Anatomy;Animals;Applications Grants;Area;Brain;Categories;Cell Therapy;Cells;cellular imaging;Classification;Climacteric;Clinical;clinical diagnosis;clinical imaging;Clinical Treatment;commercialization;Complex;contrast imaging;Coupling;design;Development;Diagnosis;Discipline of Nuclear Medicine;Disease;Electric Capacitance;Electronics;Engineering;Floor;Functional Imaging;Goals;Grant;Half-Life;Hemorrhage;Hemosiderin;Human;human imaging;Image;imager;imaging modality;imaging platform;imaging system;Imaging Techniques;Imaging technology;improved;Inflammation;Infrastructure;innovation;insight;Institution;instrument;International;magnetic field;Magnetic nanoparticles;Magnetic Resonance Imaging;Magnetism;Marketing;Measurement;Measures;Medical Imaging;Medicine;Modality;Modernization;Molecular;Monitor;nano;new technology;Noise;nuclear imaging;particle;Pathology;Performance;Phase;Physics;Physiologic pulse;Physiological;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;prototype;Radioactive;Radioactive Tracers;research clinical testing;Resolution;Roentgen Rays;Role;Safety;Scientist;Shipping;Signal Transduction;single photon emission computed tomography;Small Business Innovation Research Grant;Speed;stem cells;Structure;System;Techniques;Technology;Testing;Tissues;tool;Tracer;transmission process;ultrasound;Visualization;voltage;Work

PROJECT_TITLE: Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Pain Research;Prevention;Rehabilitation

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative  Approximately 1 million total knee arthroplasty procedures are performed in older adults each year, but 15% or more of patients report unsatisfactory long-term pain outcomes despite a technically-successful procedure. Although mechanisms contributing to chronic post-TKA pain are poorly understood, our recent prospective work suggests that elevated oxidative stress may contribute. This project will use a randomized, placebo-controlled design to test for the first time whether a potent antioxidant intervention (glycine + N- acetylcysteine) improves long-term post-TKA pain, functional, and opioid use outcomes.

PI_NAMEs: BILLINGS, FREDERIC TREMAINE;BRUEHL, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Acetylcysteine;Address;Adverse event;Affect;Alanine;Antioxidants;Arthralgia;Automobile Driving;Biological Markers;Chronic;chronic pain;Clinical;Degenerative polyarthritis;design;Enrollment;Excision;experience;F2-Isoprostanes;follow-up;Free Radicals;functional improvement;functional outcomes;Glycine;Home;Home environment;Hour;improved;in vivo;innovation;Intervention;Knee joint;knee replacement arthroplasty;Limb structure;Link;Mediating;nerve injury;Nociceptors;older adult;Operative Surgical Procedures;Opioid;Opioid Analgesics;opioid use;Outcome;Oxidative Stress;Pain;Pain intensity;pain outcome;pain reduction;Pain Research;Pathology;Patients;Perioperative;Phenotype;Placebo Control;Placebos;Postoperative Pain;Postoperative Period;precision medicine;prevent;Procedures;prospective;psychosocial;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Reperfusion Injury;Reporting;Risk;stress reduction;Subgroup;success;Surgical incisions;Testing;Time;Tourniquets;Work

PROJECT_TITLE: Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Transmembrane protein 106B (TMEM106B) is a protein that normally localizes to the lysosome and has been genetically linked to frontotemporal dementia (FTD). Recently, filaments formed from TMEM106B have been discovered in several disorders, including FTD and Alzheimer’s disease. The current project is focused on characterizing and defining patterns of TMEM106B aggregation in the brain, in addition to understanding the functional consequences of this filament deposition on the disease course.

PI_NAMEs: JOSEPHS, KEITH A;PETRUCELLI, LEONARD  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Affect;Alleles;Alzheimer's Disease;Amygdaloid structure;Amyotrophic Lateral Sclerosis;Antibodies;Autopsy;Biochemical;Biology;Brain;C9ORF72;Cell Physiology;Characteristics;Clinical;Code;Cognition;comparative;Cryoelectron Microscopy;Data;Data Set;Deposition;Disease;Disease Outcome;disorder risk;Exhibits;experimental study;Filament;fluorodeoxyglucose positron emission tomography;frontal lobe;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;Gene Cluster;Genetic;genetic variant;Genetic Variation;Genotype;Glucose;Haplotypes;Heterogeneity;Hippocampus;Histologic;human tissue;Impaired cognition;improved;Individual;Induced pluripotent stem cell derived neurons;Integral Membrane Protein;limbic-predominant age-related TDP-43 encephalopathy;Link;Linkage Disequilibrium;Lysosomes;Mass Spectrum Analysis;Measures;Metabolic;Metabolism;Methods;Mutation;N-terminal;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;Neurons;neuropathology;normal aging;novel;Outcome;Pathogenicity;Pathologic;Pathology;Pathway Analysis;Patients;Pattern;PGRN gene;Post-Translational Protein Processing;protective allele;protein protein interaction;protein TDP-43;Proteins;Proteomics;Regulation;Reporting;Resistance;Risk;risk variant;Role;sarkosyl;Serine;Single Nucleotide Polymorphism;Structure;synucleinopathy;Tauopathies;TDP-43 aggregation;Techniques;Testing;Threonine;Untranslated RNA;Variant;Work

PROJECT_TITLE: Investigating the role of TMEM106b genetics and pathology in Alzheimer’s disease, LATE and FTLD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biomedical Imaging;Brain Disorders;Neurodegenerative;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: The goal of this project is to develop a novel MRI-based biomarker that is able to detect muscle degeneration and therapy response in patients with amyotrophic lateral sclerosis. The proposed methods would leader to greater clinical trial efficiency enabling more rapid drug discovery and patient care.

PI_NAMEs: QUARLES, CHRISTOPHER CHAD (contact)

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Age;ALS patients;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotide Therapy;Architecture;Atypia;Biological;Biological Markers;biomarker discovery;biophysical properties;Cessation of life;Characteristics;Clinical;clinical heterogeneity;Clinical Markers;Clinical Trials;computer framework;contrast imaging;cost effective;data acquisition;Data Analyses;density;design;Diameter;Disease;Disease Marker;Disease Progression;drug development;drug discovery;early detection biomarkers;Edema;Exhibits;Fatty acid glycerol esters;Fiber;Foundations;Functional disorder;Functional Imaging;Goals;Health;Hospitals;Human;Image;imaging approach;imaging biomarker;improved;innovation;Magnetic Resonance Imaging;Measures;Methods;Motor Cortex;Motor Neurons;multidisciplinary;Muscle;muscle degeneration;muscle strength;Muscular Atrophy;Nerve Degeneration;Nervous System Disorder;neuroimaging;Neurologic;Neuromuscular Diseases;next generation;non-invasive imaging;novel;Pathologic;Patient Care;Patient-Centered Care;Patients;Performance;Pharmacodynamics;Phase II/III Clinical Trial;pre-clinical;Process;Protocols documentation;Quality Control;rate of change;Readiness;Reproducibility;Research;research clinical testing;Respiratory physiology;response;response biomarker;Rodent Model;Sample Size;sex;Spinal;structural imaging;superoxide dismutase 1;Therapeutic Intervention;treatment effect;treatment response;Upper Extremity;Validation

PROJECT_TITLE: Relaxivity Contrast Imaging as Biomarker of Muscle Degeneration in ALS

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: AUSTIN

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Harm Reduction Workers (HRWs) play a critical role in the substance misuse continuum of care but they are exposed to high rates of lifetime and occupational stress and trauma which is linked to adverse impacts on patient care, unmet mental health needs, turnover, burnout, and relapse. This research will adapt, field test, and conduct a hybrid-type I efficacy trial comparing the effects of Stress First Aid for HRWs versus a no- treatment control condition on social-support, burnout, secondary traumatic stress, use of mental health care, engagement, and turnover. The long-term goal of our work is to implement a sustainable and effective occupational stress intervention for HRWs nationally in order to strengthen their important role in the substance misuse work force.

PI_NAMEs: CREECH, SUZANNAH K (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: Acceleration;acceptability and feasibility;addiction;Address;Adoption;Attention;Award;burnout;Caring;Cessation of life;clinical trial protocol;Clinical Trials;Collaborations;Complex;Continuity of Patient Care;Control Groups;cost;Data;Death Rate;design;Diffusion;digital;Drug Addiction;Drug Controls;Drug user;Educational Curriculum;effectiveness evaluation;effectiveness outcome;effectiveness testing;efficacy testing;efficacy trial;Epidemic;experience;Exposure to;Familiarity;feasibility testing;Feedback;field study;First Aid;first responder;flexibility;Focus Groups;Funding;Goals;Harm Reduction;Health;health care settings;Healthcare;Helping to End Addiction Long-term;high risk;hybrid type 1 trial;Hybrids;implementation evaluation;implementation outcomes;improved;Individual;innovation;International;Intervention;intervention program;Learning;Link;Mental Health;Mental Health Services;Methods;Morbidity - disease rate;mortality;Occupational;Occupational Health;occupational stress;occupational stressor;Occupations;Opiate Addiction;Opioid;opioid misuse;opioid use disorder;Overdose;overdose death;overdose prevention;overdose risk;Participant;Patient Care;peer;peer support;Personal Satisfaction;Persons;Phase;pilot test;Play;Politics;Post-Traumatic Stress Disorders;Prevention;primary outcome;Protocols documentation;Public Health;Qualitative Methods;Quality of Care;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recovery services;Relapse;Research;Research Methodology;Resources;Role;secondary outcome;Self Care;Services;Social support;Speed;Stigmatization;stimulant use disorder;Stress;Stress Tests;Structure;substance misuse;Substance Use Disorder;System;Technology Transfer;Testing;Texas;Trainers Training;Training;Trauma;traumatic stress;treatment services;trial comparing;Trust;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Work

PROJECT_TITLE: Testing an occupational stress intervention for harm reduction workers in substance misuse settings


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative In this project, we will bring together experts from various fields of MRI and neuropathology, including post-mortem MRI, vascular pathology, image processing, and registration to develop the necessary tools and resources for analyzing post-mortem brains related to Alzheimer’s disease (AD) and AD-related dementia (ADRD) through MRI-histopathology analysis. This study will enhance our comprehension of the vascular contributions to cognitive impairment and dementia (VCID) and provide insights into the underlying mechanisms for their in vivo interpretations.

PI_NAMEs: GE, YULIN  (contact);GEE, JAMES C;WADGHIRI, YOUSSEF ZAIM;WISNIEWSKI, THOMAS M;ZHANG, JIANGYANG

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: 3-Dimensional;Access to Information;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid beta-Protein;Atlases;Autopsy;Axon;Biocompatible Materials;Blood Vessels;Brain;Brain region;brain tissue;cellular pathology;Clinical Pathology;Cognitive;cohort;Collection;Communities;Comprehension;computerized tools;Data;Data Analyses;Databases;deep learning;Dementia;Demyelinations;density;Diagnosis;Diffusion;Digital Libraries;Disease;Disease Marker;Elderly;Ensure;Formalin;Geometry;gray matter;Health;hemodynamics;Hemorrhage;Heterogeneity;Hippocampus;Histologic;Histology;histopathological examination;Histopathology;Hour;Human;Image;Image Analysis;image archival system;image processing;image registration;Imaging Techniques;in vivo;individual patient;insight;Interdisciplinary Study;Knowledge;Link;Machine Learning;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;medial temporal lobe;Methods;Microvascular Dysfunction;Modality;Modeling;Molecular;Multimodal Imaging;multimodality;multiscale data;Nature;Nerve Degeneration;Neurology;Neurons;neuropathology;neurovascular;novel;open source;Pathogenicity;Pathologic;Pathology;Pathway interactions;Predisposition;Prefrontal Cortex;Procedures;Property;Proteomics;Protocols documentation;Research;Resolution;Resources;response;sample fixation;Sampling;shared repository;Signal Transduction;Site;Software Tools;Specimen;Stains;Standardization;Structure;tau Proteins;TBI Patients;Techniques;Therapeutic;Therapeutic Intervention;tissue fixing;Tissues;tool;tractography;vascular abnormality;vascular cognitive impairment and dementia;white matter;White Matter Hyperintensity

PROJECT_TITLE: Multi-scale and multi-modality imaging of neuropathology in VCID


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sepsis;Social Determinants of Health;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Sepsis is the second leading cause of maternal death in the U.S. For racial and ethnic minoritized birthing people, especially those who are Black, living in poverty, and from underserved communities, labor and postpartum are particularly vulnerable risk periods. We propose a multicenter, multidisciplinary study, with community co-leadership and co-design, to evaluate a maternal sepsis safety bundle, optimize risk prediction accounting for the social determinants of health, and establish a novel maternal care continuity model to reduce sepsis-related death and disability and increase maternal health equity.

PI_NAMEs: FRIEDMAN, ALEXANDER M;GOFFMAN, DENA ;HALL, KELLI STIDHAM;REDDY, UMA  (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Accountability;Accounting;adverse maternal outcomes;Advocacy;Affect;Algorithms;Biometry;Birth;Black race;Caring;Cessation of life;Clinical;clinical risk;Communication;Communities;community engaged research;community engagement;Community Health Aides;community organizations;community partners;community partnership;community research;community-centered;Continuity of Patient Care;Data Set;Databases;design;disability;Disadvantaged;Discipline of Nursing;Discipline of obstetrics;Disparity;Education;Effectiveness;Electronic Health Record;Ensure;Equity;ethnic diversity;ethnic minority;Ethnic Origin;evidence base;Evidence based intervention;experience;Focus Groups;health care availability;health equity;health inequalities;Health Services Accessibility;Health Services Research;Health system;health training;high risk;Hospitals;implementation framework;implementation process;implementation science;implicit bias;improved;Individual;individual patient;Inequity;Informatics;inpatient service;Inpatients;Institution;Intervention;Interview;Joints;Knowledge;Leadership;Lived experience;machine learning model;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;maternal outcome;maternal risk;Maternal-fetal medicine;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Neighborhoods;novel;Outcome;outcome disparities;Outcome Measure;patient oriented;Patients;Pattern;Perinatal;Persons;Phase;Policies;postpartum morbidity;Postpartum Period;Poverty;Pregnancy;prevent;Prevention;Process;Process Measure;Protocols documentation;Provider;Quality of Care;Race;racial diversity;racial minority;Readiness;Reporting;Research;Research Infrastructure;Resources;response;Risk;risk prediction;Risk Reduction;Safety;Sampling;screening;Sepsis;Services;severe maternal morbidity;Site;social;Social Environment;social epidemiology;social health determinants;Social Sciences;socioeconomic disadvantage;standard of care;Standardization;Structural Racism;support network;Supportive care;System;Training;Translating;underserved community;Use Effectiveness;Variant

PROJECT_TITLE: EnCoRe MOMS: Engaging Communities to Reduce Morbidity from Maternal Sepsis


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Primary Health Care

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: PROJECT NARRATIVE Disparities in PrEP uptake persist in the United States, particularly among priority populations (e.g., men who have sex with men, Black and Latino individuals), as estimates show only 9% of Blacks and 16% of Latinos who met the indications were prescribed PrEP. Barriers to PrEP prescription exist in the primary care setting for providers and patients; this study will be the first known application of the multiphase optimization strategy (MOST) framework to test the effect of intervention components aimed to increase PrEP initiation in primary care, alone and in combination, in an optimization trial. The proposed research will yield important insights into what combination of intervention components delivers the most efficient intervention to providers and patients and what factors affect PrEP uptake among priority populations.

PI_NAMEs: LOCKHART, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Affect;Age;AIDS prevention;Awareness;Black Populations;Black race;care providers;Clinic;Computer Simulation;Consolidated Framework for Implementation Research;Continuing Education;County;Critical Care;Disparity;disparity reduction;Effectiveness;Effectiveness of Interventions;effectiveness testing;Electronic Health Record;Eligibility Determination;Epidemic;Equity;evidence base;experience;experimental study;Family Practice;Feedback;Focus Groups;Gender;Health;Health system;Healthcare Systems;HIV;HIV risk;HIV Seronegativity;Human immunodeficiency virus test;Individual;Inequity;Injections;innovation;insight;Internal Medicine;Intervention;intervention effect;Interview;Knowledge;Latino Population;Lead;Maintenance;Mediating;Mediator;Medical;meetings;men who have sex with men;Methods;Michigan;Modification;multiphase optimization strategy;novel;Online Systems;Participant;Patient Care;patient-clinician communication;Patients;Persons;pill;Population;post implementation;pre-exposure prophylaxis;Primary Care;primary care patient;primary care provider;primary care setting;primary outcome;Provider;provider intervention;Race;Randomized;Research;Rights;Risk;Risk Assessment;Sampling;secondary outcome;sex;Sex Behavior;Sex Orientation;Sexual Health;Structure;System;Testing;Training;United States;uptake;Work

PROJECT_TITLE: A Multilevel, Multiphase Optimization Strategy for PrEP: Patients and Providers in Primary Care


NIH_SPENDING_CATS: Aging;Estrogen;Genetics;HIV/AIDS;Infectious Diseases;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative There are distinct sex-based differences that affect the natural history and immune pathogenesis of HIV infection. These factors likely impact the establishment, distribution, and transcriptional activity of the HIV reservoir. Our study will determine the effect of declining sex hormones on HIV persistence and inflammation in midlife women during all stages of reproductive aging while on suppressive antiretroviral therapy and define underlying mechanism.

PI_NAMEs: GIANELLA WEIBEL, SARA  (contact);KARN, JONATHAN

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Affect;Aftercare;Age;Aging;Algorithms;Antibodies;antiretroviral therapy;Area;Automobile Driving;Bar Codes;biobank;Bioinformatics;Biological;Biological Assay;Biometry;Blood Cells;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Survival;cis-female;cis-male;Clinical;Clinical Data;Clonal Expansion;cohort;Cohort Studies;Collaborations;cytokine;Cytokine Network Pathway;Data;design;Detection;DNA;Estradiol;Estrogen decline;Estrogens;Exclusion;experience;experimental study;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;Gonadal Steroid Hormones;HIV;HIV Infections;HLA-DR Antigens;Hormones;human subject;IL7 gene;Immune;immune activation;Immune response;immunological intervention;Immunologics;Immunology;Immunophenotyping;improved;inclusion criteria;Infection;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Inflammatory Response Pathway;insight;integration site;Interferon Type II;Knowledge;longitudinal design;male;Measures;Mediating;men;Midlife women;monocyte;multimodal data;Natural History;Natural Killer Cells;novel;Participant;Pathogenesis;Pathway interactions;Perimenopause;Peripheral;Pilot Projects;Plasma;Postmenopause;Premenopause;Process;Productivity;Proliferating;Protocols documentation;Race;Recording of previous events;Repression;reproductive;reproductive senescence;Research;response;RNA;Role;Sampling;Series;sex;Sex Differences;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Site;Specimen;Standardization;Statistical Data Interpretation;T-Cell Activation;Testing;The Multicenter AIDS Cohort Study;Therapeutic;Time;time interval;Transcript;Transcriptional Regulation;transcriptomics;Viremia;virology;Woman;women versus men;Women's Interagency HIV Study;women's outcomes;Work

PROJECT_TITLE: Sex-differences in HIV persistence and Immune Dynamics during Reproductive Aging


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Our goal is to establish the DMCU (Data Management and Coordinating Unit) to support the liquid biopsy consortium for consortium coordination, data management, protocol development, as well as innovative and state-of-the-art statistical and computational analysis.

PI_NAMEs: SUN, WEI ;ZHENG, YINGYE  (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;Adoption;Area;Artificial Intelligence;Benign;big data management;Bioinformatics;Biological Assay;Biological Markers;biomarker development;biomarker validation;Biometry;Biopsy;Blood;Body Fluids;Cancer Center;Cancer Detection;cancer diagnosis;Cancer Patient;cancer type;Cancerous;Caring;cell free DNA;Cerebrospinal Fluid;Clinical;cloud storage;Collaborations;Collection;Common Data Element;Communication;Communities;Community Outreach;Computational Biology;Computer Analysis;Confidence Intervals;curative treatments;Data;Data Analyses;data centers;Data Coordinating Center;Data Element;data management;Data Science;data sharing;data standards;Data Storage and Retrieval;deep learning;design;Detection;Development;Disease;Early Detection Research Network;Educational workshop;exosome;experience;extracellular vesicles;federated learning;Goals;Image;improved;Indolent;Informatics;innovation;laboratory experience;Leadership;Lesion;liquid biopsy;Machine Learning;machine learning model;machine learning prediction;Malignant Neoplasms;Manuals;meetings;member;Methods;minimally invasive;Molecular;molecular imaging;Morbidity - disease rate;mortality;multidisciplinary;National Cancer Institute;Neoplasm Circulating Cells;notch protein;novel;operation;outreach;Patients;Performance;Population;Positioning Attribute;pre-clinical;premalignant;Procedures;programs;prospective;Proteins;protocol development;Reproducibility;Reproducibility of Results;Research;research clinical testing;Research Design;Research Methodology;Research Personnel;Research Support;Resources;response;RNA;Saliva;Science;Scientific Advances and Accomplishments;Screening for cancer;Secure;Sensitivity and Specificity;service coordination;Somatotype;Specimen;Sputum;Standardization;Statistical Data Interpretation;Statistical Methods;statistics;symposium;System;Techniques;Technology;Tissues;Translational Research;tumor;tumor DNA;Urine;Validation;validation studies;web site;Work

PROJECT_TITLE: Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Data Management and Coordinating Unit


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: Through recent innovations in imaging techniques and the ability to process these images at scale, we have unprecedented access to public datasets of molecular and cellular spatial patterns of organization. To make full use of these new spatially-complex data streams, to understand the dynamical processes that are shaping cellular and molecular spatial collectives, to go beyond simple description of pattern towards understanding of function and adaptive design, we must rst develop a predictive theory of complex spatial structure. My group builds mathematical representations of the spatial architecture of molecular and cellular biological systems and studies the evolutionary-relevant properties of these complex spatial topologies.

PI_NAMEs: CARJA, OANA  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Acceleration;Architecture;Area;biological systems;Biology;Cations;cell community;Complex;complex data;Computer Interface;Computer Vision Systems;Data Set;data streams;Demographic Survey;design;Disease;Evolution;Genetic Models;high resolution imaging;Image;Imaging Techniques;Industrialization;innovation;interest;Link;Mathematics;Medical;migration;Modeling;Modernization;Molecular;Molecular Biology;Mutation;Organoids;Outcome;Pathogenicity;Pattern;Population;Population Genetics;Process;programs;Property;protein complex;Research;Role;Screening procedure;Shapes;Structure;System;Technology;theories;Variant

PROJECT_TITLE: From pattern to function: eco-evolutionary representations of complex spatial structure for the new era of spatial biology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: LARAMIE

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: Project Narrative Sundowning syndrome, characterized by agitation, aggressiveness, and wandering during the late afternoon and early evening, occurs in about 20% of Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD) patients and often leads to institutionalization. Using mouse models of AD/ADRD and other transgenic mouse lines, we will examine the role of a novel neural pathway from the brainstem to the circadian system in temporal disturbances of body temperature, locomotor activity, and behavioral aggression that are relevant to those seen in sundowning. This project may lead to a better understanding of sundowning-related circadian dysfunction and may suggest an eventual therapy that could greatly improve the quality of life for AD/ADRD patients and their caregivers.

PI_NAMEs: TODD, WILLIAM DAVID (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Ablation;Acute;Address;aged;Aggressive behavior;Aging;Agitation;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid beta-Protein;Animal Model;Area;Behavioral;Body Temperature;Brain Stem;Caregivers;Cholecystokinin;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical;comorbidity;Darkness;Dynorphins;Enterobacteria phage P1 Cre recombinase;Female;Functional disorder;genetic manipulation;Goals;hyperphosphorylated tau;Hypothalamic structure;improved;Institutionalization;Lateral;Lead;Light;male;Modeling;Motor Activity;mouse model;Mus;Mutation;Nerve Degeneration;Neural Pathways;Neuroanatomy;Neurobehavioral Manifestations;Neurobiology;Neurons;novel;parabrachial nucleus;Pathology;Pathway interactions;Patients;Phase;Phase Transition;Physiological;Population;postsynaptic;pre-clinical;Quality of life;Research Project Grants;Resting Phase;Role;Site;suprachiasmatic nucleus;Symptoms;Syndrome;System;Testing;tetra-4-amidinophenoxypropane;therapeutic target;Time;Transgenic Mice;vector;Wild Type Mouse

PROJECT_TITLE: The circuit basis of sundowning-related circadian dysfunction in Alzheimer's  disease and Alzheimer's disease-related dementias

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: PEDIATRICS

PHR: Traumatic brain injury (TBI) is a major cause of death and disability across all ages. Primary mechanical damage induced brain tissue disruption after TBI progressively expands due to secondary injury mechanisms. Lipid peroxidation and subsequent cell demise via a recently discovered program of regulated death, ferroptosis, are important mechanisms involved TBI pathogenesis. However, the information on the types of cells in which these two aberrant processes are occurring and the major TBI-induced deficiencies in their regulation remain unknown, largely due to the lack of adequate methods. The goal of this application is to optimize and apply developed by us entirely new and revolutionizing technology – multi-omics imaging based on the employment of specifically designed secondary ion mass spectrometry (SIMS) and permitting simultaneous high-resolution imaging of three major types of biomolecules – lipids, proteins, and metabolites. Thus, not only the types of cells in TBI brain will be reliably identified but also accurate and quantitative information on changes of the amounts of oxidatively modified lipids and other metabolites will be determined in different subcellular compartments. By correlating this information with the data on neuropathology of the injured brain we will be able, for the first time, to decipher the mechanisms of lipid peroxidation driving ferroptotic death in specific cell types during TBI progression. Consequently, new effective and selective small molecule regulators of ferroptosis-inducing lipid peroxidation will be developed for targeted therapies and for evaluation of their efficacy in TBI.

PI_NAMEs: BAYIR, HÜLYA  (contact);KAGAN, VALERIAN E;TIAN, HUA

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: acyl group;Address;Age;Amides;amino group;Anabolism;anandamide;Anti-Inflammatory Agents;antibody conjugate;Arachidonate 15-Lipoxygenase;Arachidonic Acids;Area;Automobile Driving;Binding Proteins;Biology;Brain;Brain Injuries;brain tissue;catalyst;Cause of Death;Cell Death;cell type;Cells;Cessation of life;Clinical;Coenzyme A Ligases;Complex;controlled cortical impact;Data;design;disability;effectiveness evaluation;Employment;Endocannabinoids;Evaluation;Family member;Gases;Generations;Goals;high resolution imaging;Image;Imaging Techniques;Imaging technology;Individual;Inflammation;Inflammatory Response;inhibitor;Injury;innovation;Intracranial Hypertension;Ions;Label;Lanthanoid Series Elements;Lateral;Lipid Peroxidation;lipidomics;Lipids;Liquid Chromatography;Maps;mass spectrometric imaging;Mechanics;meter;Methods;Minor;Modeling;Molecular;multiple omics;Mus;Necrosis;neuropathology;novel;oxidation;Oxidation-Reduction;Pathogenesis;Pathway interactions;peroxidation;Phosphatidylethanolamine;Phospholipids;Positioning Attribute;Process;programs;protein complex;Proteins;Protocols documentation;Reaction;Refractory;Regulation;Resolution;Role;Scaffolding Protein;Secondary to;Series;Signal Transduction;small molecule;Specificity;Spectrometry, Mass, Secondary Ion;targeted treatment;TBI Patients;Technology;Testing;Three-Dimensional Imaging;Time;Tissues;transacylation;Traumatic Brain Injury;Water;young adult

PROJECT_TITLE: Lipid Imaging in Traumatic Brain Injury by High Resolution GCIB-secondary Ion Mass Spectrometry

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Genetics

PHR: 8. Project Narrative Our discovery of the nitrate signaling network controlled by three types of evolutionarily conserved master regulators, the dual NLP nitrate-sensor/transcription factors, the Ca2+- sensor/transducer protein kinases (CPKs), and the master nutrient signaling hub TOR will help uncover the poorly understood molecular links in nutrient regulation of transcription, metabolism, and organ growth in plants, which are the core to agricultural and bioenergy productivity for sustaining human life and the ecosystems on the planet. The new concepts and mechanisms revealed from this nutrient-triggered Ca2+ signaling represent a paradigm shift in current research on nutrient regulation in multicellular organisms from plants to humans and may aid the elucidation of transcriptional networks coupling metabolic regulation and organ growth pivotal to the health, longevity, and diseases of animals and humans. As plants play a central role in bridging the conversion of inorganic nitrogen to organic nitrogen in the global nitrogen cycle, the proposed studies will lead to fundamental knowledge with sustained impact on nutrient signaling central to plant biology, environmental protection, as well as human nutrition and health.

PI_NAMEs: SHEEN, JEN  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Agriculture;Amino Acids;Animal Diseases;Animals;Arabidopsis;Architecture;Biochemical;biological systems;Biology;Biomass;Calmodulin;Carbon;Cell Nucleus;chemical genetics;combinatorial;Complex;Coupled;Coupling;Cytoplasm;Development;Developmental Process;Ecosystem;Environmental Protection;experimental study;functional genomics;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic analysis;Genetic Screening;Genetic Transcription;genome-wide;Genomics;Goals;Growth;Growth Factor;Health;Human;innovation;Knowledge;Lateral;Life;Link;Longevity;Mediating;Metabolic;Metabolism;Methodology;Molecular;Mouse-ear Cress;mutant;Nitrates;Nitrogen;Nodule;novel;Nucleic Acids;Nutrient;nutrition;Organ;organ growth;Organism;Phosphorylation;Phosphotransferases;Physiological;Phytonutrients;Planets;plant growth/development;Plant Roots;Plant Shoots;Plants;Play;Productivity;programs;protein complex;Protein Kinase;Proteins;Regulation;Reiterated Genes;Research;Research Project Grants;response;Role;sensor;Shapes;Signal Transduction;Signaling Molecule;Sirolimus;Somatotropin;Subgroup;success;System;Systems Analysis;Transcription Coactivator;transcription factor;Transcriptional Regulation;transcriptional reprogramming;transcriptome;Transducers;Transgenic Organisms

PROJECT_TITLE: Plant Nutrient-Growth Signaling Network

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Neurosciences;Nutrition;Obesity;Prevention;Rehabilitation

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This project proposes to develop a battery-free, flexible, and implantable piezoelectric nanogenerator device that performs closed-loop biofeedback electrostimulation (ES) on the vagus nerves to control food intake. This device is attached on the stomach surface and generates tunable ES signals in response to stomach peristalsis upon food intake. This project will establish an essential biological and engineering foundation that will allow us to move rapidly to the next step of in vivo studies using this closed-loop neuromodulation technique in large animal models, eventually leading to human trials.

PI_NAMEs: WANG, XUDONG  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Address;Adult;adult obesity;Animal Model;Animals;bariatric surgery;Benchmarking;Biocompatible Materials;Biofeedback;Biological;biomaterial compatibility;Body Weight decreased;Charge;Clinic;Clinical;comparison control;design;Development;Devices;dietary control;Eating;Eating Behavior;Electric Stimulation;Electronics;Engineering;Evaluation;Extravasation;Feedback;Film;flexibility;Foundations;Glycine;Human;Implant;implantable device;implantation;In Vitro;in vivo;interest;Legal patent;Maintenance;mechanical properties;Mechanics;miniaturize;Modeling;Motion;Movement;multidisciplinary;neuroregulation;novel;Obesity;obesity treatment;operation;Output;packaging material;peer;Performance;Peristalsis;Physiologic pulse;Physiology;randomized trial;Rattus;Reporting;response;Series;side effect;Signal Transduction;Site;Stomach;Structure;Surface;Techniques;Technology;Testing;Therapeutic Intervention;Time;Treatment Efficacy;vagus nerve stimulation;Vagus nerve structure;Weight Gain;Weight maintenance regimen;Width;Work

PROJECT_TITLE: Implantable Self-Powered Biofeedback Vagus Nerve Stimulator for Weight Control

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Radiation Oncology;Rare Diseases;Social Determinants of Health

PHR: NARRATIVE Sarcomas represent a heterogenous group of tumors that affect individuals across the lifespan. Determining disease, survivor, treatment, lifestyle and genomic factors that contribute to oncologic (treatment response, recurrence) and non-oncologic outcomes (treatment toxicity, quality of life) and survival in sarcoma patients is critical for strategic surveillance for current survivors and to inform future therapies. Furthermore, strategies to monitor disease through liquid biopsy approaches has tremendous potential as both a prognostic and predictive biomarker, to guide therapeutic interventions.

PI_NAMEs: FRIEDMAN, DEBRA L. (contact);PAL, TUYA ;PARK, BEN HO;SHU, XIAO-OU

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: 15 year old;Abstinence;Academic Medical Centers;Address;Adjuvant Chemotherapy;Affect;Alcohol consumption;Biological Assay;Biology;Blood specimen;cancer diagnosis;Cancer Survivor;cancer therapy;Caring;Cessation of life;Chemotherapy and/or radiation;childhood cancer survivor;cigarette smoking;circulating biomarkers;Clinical;Clinical Data;cohort;Cohort Studies;Connective Tissue;Data;Dedications;design;Diagnosis;Diet;Disease;DNA analysis;DNA Repair Gene;drug metabolism;Electronic Health Record;epidemiologic data;Exercise;financial toxicity;follow-up;Foundations;functional outcomes;functional status;Future;Gene Expression;Genetic Polymorphism;Genetic Predisposition to Disease;genetic risk factor;genome sequencing;Genomics;Germ Lines;Goals;Grant;Health;healthy lifestyle;Heart Diseases;improved;improved outcome;Incidence;indexing;Individual;Infrastructure;Investigation;Kidney Diseases;Knowledge;Life;life span;Life Style;lifestyle factors;liquid biopsy;Liver diseases;Lung Diseases;Medical Oncologist;Mesenchymal;Micrometastasis;molecular marker;Monitor;mortality;Neoadjuvant Therapy;Newly Diagnosed;next generation sequencing;Normal tissue morphology;Oncogenes;Organ;Orthopedics;Outcome;Participant;Patient Outcomes Assessments;Patients;Pediatric Oncologist;peripheral blood;physical conditioning;polygenic risk score;Population;Precision therapeutics;Predictive Factor;predictive marker;Prevalence;Prognostic Factor;Prognostic Marker;prognostic value;programs;prospective;Prospective cohort;psychologic;psychosocial;psychosocial outcome;Quality of life;Radiation Oncologist;Radiation therapy;rare cancer;recruit;Recurrence;Relapse;Research;Residual Neoplasm;response;Risk Factors;Role;Sampling;Sarcoma;Severities;social;sociodemographics;Somatic Mutation;Specialist;surveillance strategy;Surveys;Survivors;survivorship;Tennessee;Therapeutic Intervention;Time;tool;Toxic effect;transcriptomics;treatment center;Treatment Efficacy;treatment response;Treatment-Related Cancer;Treatment-related toxicity;tumor;Tumor Biology;tumor DNA;Tumor Subtype;Tumor Tissue;United States;Variant;whole genome

PROJECT_TITLE: CAUSAL: Cohort to Augment the Understanding of Sarcoma Survivorship Across the Lifespan


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Mild traumatic brain injury (mTBI) is highly prevalent and can potentially have long-lasting consequences for the brain, cognitive function, and behavior, including elevated risk for substance abuse and psychopathology. In this study, we will use a powerful and rigorous cotwin control approach to identify causal effects of TBI by comparing twins with mTBI history with their identical cotwins who never had a TBI. A better understanding of long-lasting consequences of childhood and adolescent mTBI will promote the development of more efficient treatment and rehabilitation efforts, as well as prevention of substance abuse and psychopathology frequently associated with mTBI history.

PI_NAMEs: ANOKHIN, ANDREY P. (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: addiction;Addictive Behavior;Adolescence;Adolescent;adverse outcome;Age;Anxiety;Behavior;Behavioral;Brain;brain control;Brain Injuries;case control;Case/Control Studies;Childhood;Cognition;cognitive function;comorbidity;coping;Corpus Callosum;Correlative Study;Cross-Sectional Studies;Data Analyses;design;Development;Diffusion Magnetic Resonance Imaging;Discrimination;early adolescence;early onset substance use;Electroencephalography;Electrophysiology (science);emotion regulation;Equation;Etiology;Event;Female;follow up assessment;follow-up;Functional impairment;Functional Magnetic Resonance Imaging;Goals;gray matter;Heritability;Heterogeneity;High Prevalence;high risk;Impulsivity;individual variation;innovation;insight;Knowledge;Link;long-term sequelae;Magnetic Resonance Imaging;Mediating;Mental disorders;Mental Health;Methodology;Methods;mild traumatic brain injury;Modality;Modeling;Monozygotic twins;multimodal neuroimaging;multimodality;negative affect;neural;neurobehavioral;Neurocognitive Deficit;neurodevelopment;neuroimaging;Neurons;neurophysiology;Neuropsychology;novel;Pathway interactions;Performance;physical conditioning;Prevention;prospective;Psychopathology;Public Health;Recording of previous events;Rehabilitation therapy;Reporting;Resolution;Rest;Risk;Risk Factors;risk sharing;Role;Self Medication;stress reactivity;Structure;substance abuse prevention;Substance abuse problem;substance use;Substance Use Disorder;substance use prevention;Symptoms;Techniques;temporal measurement;Testing;Thick;tool;Trauma;Twin Multiple Birth;white matter;Youth

PROJECT_TITLE: Neurobehavioral consequences of Mild Traumatic Brain Injury and addiction risk: a cotwin-control study

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Successful HIV cure requires eradication of virus from all reservoirs to prevent recrudescence in anatomically distinct locations including the CNS, where microglia and macrophages are a potential HIV reservoir; however, our knowledge of the mechanisms underlying HIV latency, persistence, and reactivation in these cell populations in the presence of non-HIV-related comorbidities such as cocaine are limited due to major barriers. Our novel approach using state-of-art technologies and models will define discreet cell subtypes infected with HIV in complex multicellular contexts in the presence of cocaine and will address a critical gap in our knowledge that is needed to eliminate HIV reservoir in the CNS of PWH with substance use disorders, while also developing physiologically relevant platforms to identify novel targets for effective latency reversal strategies, antiretroviral drugs, and adjunctive neuroprotective therapies in the CNS.

PI_NAMEs: AKAY ESPINOZA, CAGLA ;JORDAN-SCIUTTO, KELLY L (contact);SU, YIJING

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Address;Anatomy;Anti-Retroviral Agents;antiretroviral therapy;Autopsy;Bar Codes;Bioinformatics;Blood Vessels;CD4 Positive T Lymphocytes;Cell Line;Cell Physiology;cell type;Cells;Characteristics;Cocaine;cocaine exposure;cocaine use;comorbidity;Complex;Detection;DNA;DNA Integration;DNA sequencing;examination questions;Exhibits;Fostering;Gene Expression Profile;Genetic Transcription;Genome;HIV;HIV Infections;human induced pluripotent stem cells;improved;In Vitro;in vivo;indexing;Individual;Inflammation;Inflammatory;insight;Knowledge;latent HIV reservoir;Libraries;Life Expectancy;Link;Location;Macrophage;Mediating;Methods;Microglia;Modeling;Molecular;Molecular Profiling;multimodality;Myelogenous;Myeloid Cells;National NeuroAids Tissue Consortium;Neurologic;neuroprotection;neuropsychiatry;novel;novel strategies;novel therapeutic intervention;Nuclear;Outcome;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phase;Physiological;Population;prevent;Printing;Productivity;proteogenomics;Proviruses;Recording of previous events;Recrudescences;Regimen;Reporting;Residual state;Resolution;RNA;Special Equipment;Specimen;Stimulant;Substance Use Disorder;Surface;T-Lymphocyte;Technology;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;Viral;Virus

PROJECT_TITLE: Multimodal profiling of microglia during HIV infection and substance use disorder


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE The proposed study is highly significant because it addresses the growing health-harming legal needs impacting vulnerable Latinx and recent migrant communities affected by intersecting epidemics. Testing a critical-time intervention medical-legal partnership (CTI-MLP) approach, as the one proposed in this study, could improve patient-reported overall global health by mitigating health harming legal needs and addressing social and structural barriers to care for medically underserved communities. Completion of this project will result in the development of an innovative, evidence-based intervention package to prevent and reduce health inequities, improve patient and community health outcomes, and advance health equity among historically marginalized populations.

PI_NAMEs: MALAVE-RIVERA, SOUHAIL M;MARTINEZ, OMAR ;MUNOZ-LABOY, MIGUEL A (contact);RODRIGUEZ-DIAZ, CARLOS EMANUEL

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Address;Affect;alcohol use disorder;arm;Asthma;Award;Awareness;barrier to care;Cardiovascular system;care outcomes;Caribbean region;Caring;Clinic;Clinical;cluster randomized design;Communicable Diseases;Communities;community advisory board;community engagement;Community Health;Consolidated Framework for Implementation Research;Continuity of Patient Care;cost effective;Costs and Benefits;COVID-19;Data;Development;Diabetes Mellitus;Disability Insurance;Discrimination;Domestic Violence;Early Diagnosis;Education;effectiveness testing;effectiveness/implementation trial;Employment;enhancing factor;Ensure;Epidemic;Evidence based intervention;experience;Fatigue;Federally Qualified Health Center;Food Access;food security;Gills;global health;Health;health care delivery;health care service;health disparity;health equity;health inequalities;Health Insurance;Health Services;Healthcare;Healthcare Systems;Heart Diseases;HIV;Housing;Hybrids;Hypertension;implementation outcomes;implementation science;implementation strategy;improved;Individual;innovation;Insurance;Insurance Coverage;Intervention;Latin America;Latino;Latinx;Lead;Legal;Legal Intervention;Long Island;Low income;marginalization;marginalized community;marginalized population;Medicaid;Medicaid services;Medical;Medical center;medical schools;medically underserved;medically underserved population;Mental Depression;Mental Health;Metabolic;Migrant;migration;Modeling;Neighborhood Health Center;New York;Outcome;Pain;patient-clinician communication;Patient-Focused Outcomes;Patients;Perceived quality of life;Persons;physical conditioning;Population;prevent;Primary Care;primary care patient;primary care provider;professional atmosphere;programs;prototype;Public Health Schools;Puerto Rico;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recovery;Reduce health disparities;Reporting;Research Personnel;research study;Resources;Risk Factors;Safety;scale up;Schools;Service delivery model;Services;Severities;social;social determinants;Social Welfare;standard of care;Substance Use Disorder;System;systemic barrier;Testing;Time;Translations;underserved community;United States;United States National Institutes of Health;Universities;urban setting;vulnerable community;Work;Workplace

PROJECT_TITLE: Addressing durable health disparities through critical time legal interventions in medically underserved Latinx and migrant communities in the United States.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PONCE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PONCE SCHOOL OF MEDICINE

ORG_STATE: PR

PHR: The Partnership between Ponce Health Sciences University (PHSU) in Puerto Rico and the Moffitt Cancer Center (MCC) in Tampa is focused on reducing cancer disparities in the Hispanic/Latino (H/L) communities and contributing to the elimination of health disparities in the H/L population at large. The Partnership aims to provide the means to expand research capabilities of the ISUPS (PHSU) and enhance research on cancer health disparities at the NCI-designated Cancer Center (MCC). The joint programs have resulted in successful outcomes in cancer research, education, training, community outreach and in biobanking.

PI_NAMEs: ARMAIZ-PENA, GUILLERMO N;MONTEIRO, ALVARO N;SAAVEDRA, HAROLD I (contact)

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TERMS: Accreditation;Achievement;Address;Admixture;Advocate;Affect;anti-cancer research;Basic Cancer Research;Basic Science;Bay Region;biobank;Biological;Cancer Center;cancer clinical trial;cancer education;cancer health disparity;Cancer Patient;career;Caregivers;catalyst;Clinical;Clinical Research;Collaborations;Communication;Communities;Community Developments;community empowerment;community engagement;Community Health;Community Health Education;Community Outreach;Complex;Comprehensive Cancer Center;COVID-19 pandemic;Development;Direct Costs;disparity gap;Doctor of Philosophy;doctoral student;Earthquakes;Education;Educational Materials;Ensure;Environment;Evaluation;Evaluation Research;Evolution;experience;Faculty;Florida;forging;Fostering;Funding;Genetic;genomic data;Genomics;Goals;graduate medical education;Grant;Growth;Health;Health Disparities Research;health disparity;Health Educators;Health Sciences;Health Services Accessibility;Hematology;Hispanic;Hurricane;improved;Infrastructure;innovation;Institution;inter-institutional;Intervention;Joints;Language;Latino;Latino Population;Malignant Neoplasms;Medical;Medical Students;Minority Participation;Natural Disasters;NCI-Designated Cancer Center;novel;Oncology;Operative Surgical Procedures;Outcome;outreach;outreach program;Peer Review;Population;Postdoctoral Fellow;Poverty;Preparation;Process;Productivity;programs;Psychological Factors;Publications;Puerto Rico;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Support;Residencies;resilience;Resources;Science;social factors;social media;Specimen;Tissue Microarray;Training;translational cancer research;undergraduate student;Universities

PROJECT_TITLE: (1/2) Ponce Health Sciences University-Moffitt Cancer Center Partnership #


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: MATTA, JAIME L (contact)

PROJECT_TERMS: Advisory Committees;Affect;anti-cancer research;Area;Brassicaceae;Budgets;Cancer Center;cancer health disparity;career;career development;Career Mobility;Categories;Collaborations;Committee Members;Communication;Communities;Community Health;conflict resolution;COVID-19 pandemic;Development;Doctor of Philosophy;driving force;Earthquakes;education research;Ensure;expectation;experience;Faculty;Fostering;Funding;Funding Agency;Future;Goals;Grant;Growth;Guidelines;Health Disparities Research;Health Educators;Health Sciences;Hispanic;Hurricane;Incubators;Infrastructure;innovation;Institution;Knowledge;Latino;Leadership;member;Mentors;minority engagement;minority health;pandemic disease;Persons;Preparation;Productivity;programs;Progress Reports;Publications;Puerto Rico;recruit;Recruitment Activity;Research;Research Activity;Research Personnel;Research Project Grants;resilience;Resource Development;Resource Sharing;Resources;Scientist;Source;success;Supervision;Training Activity;Underrepresented Minority;United States National Institutes of Health;Universities;virtual;Work

PROJECT_TITLE: Administrative  Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Project Narrative There is a critical gap in understanding hospital- and structural-level causes leading to maternal mortality and severe maternal morbidity (SMM), particularly with regard to preventable deaths. Our central hypothesis is that social determinants of health and hospital factors significantly impact maternal and pregnancy outcomes, and are more prognostic for BIPOC (Black, Indigenous, People of Color) populations. The proposed research is innovative, as it will (a) use data to develop and validate a prognostic scoring tool for maternal mortality/SMM that goes beyond individual-level factors; (b) assess hospital-level factors that may contribute to maternal mortality, by using data from 128 separate health systems in Cerner's Real-World DataTM (RWD) national database; (c) integrate geocoding and linked death data to enable better estimates of structural and social determinants of health (SSDoH) factors that contribute to maternal mortality/SMM; and (d) facilitate a rapid “scale-up” to a national level, given the multi-site nature of the Greater Plains Collaborative (GPC)/PCORnet data system.

PI_NAMEs: HSU, ALBERT L (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Address;allostatic load;American;Biological;Birth;Black race;Black, Indigenous, People of Color;Caring;Catchment Area;Censuses;Cessation of life;Clinical;Clinical Data;Communication;Community Surveys;comorbidity;comparative effectiveness study;complex data;Country;Data;Data Collection;Data Set;Databases;Death Rate;demographics;Diagnosis;Employment;ethnic disparity;Event;experience;explicit bias;Family;Future;Great Plains;Green space;Health;Health system;Healthcare;Heart Diseases;Hemorrhage;high risk;Hospitals;implicit bias;Income;Indigenous;Individual;ineffective therapies;Inequity;Information Systems;innovation;Institution;Insurance Coverage;Knowledge;Link;Maternal Mortality;maternal outcome;Measurable;Measures;Medical;Missouri;Modeling;mortality;mortality risk;Nature;Neighborhoods;Outcome;Patient-Focused Outcomes;Patients;people of color;Persons;Population;Postpartum Period;Pregnancy;Pregnancy Outcome;pregnant;preventable death;Privacy;prognostic;prospective;Protocols documentation;Provider;Race;racial disparity;racism;Records;Relative Risks;Research;Research Institute;residence;residential segregation;Review Committee;Rural;scale up;segregation;Sepsis;Services;severe maternal morbidity;Site;social;social health determinants;Social Security;socioeconomic disparity;structural determinants;structural health determinants;Structural Racism;System;systems research;Testing;tool;Translating;Universities;University Hospitals;Utah;walkability

PROJECT_TITLE: DRIVERs:  Data systems Research to Identify driVers of Ethnic & Racial Inequities in Maternal Mortality

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: FLORES, IDHALIZ  (contact)

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Awareness;biobank;Blood;Breast;Breast Cancer Genetics;breast cancer genomics;Cancer Center;cancer diagnosis;cancer health disparity;cancer therapy;cancer type;Caribbean region;Clinical;Clinical Data;Clinical Trials;Collaborations;Colon;Colorectal Cancer;Communities;Community Health;Community Health Education;Community Outreach;Consent;Data;data registry;Data Set;Databases;Dedications;Demographic Survey;Development;DNA;Education;Education and Outreach;education research;exome sequencing;Funding;Future;Genetic;Genome;Germ Lines;Grant;Gynecologist;Health Disparities Research;health disparity;Health Educators;Health Sciences;Historical Survey;Hospitals;improved;Individual;innovation;International;Island;Latin America;Latin American;Latino;Logistics;Lung;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;Medical Students;Minority Participation;Molecular;molecular phenotype;Molecular Profiling;neoplasm registry;novel;Oncologist;Organoids;outreach;Ovarian;patient derived xenograft model;Patient Education;Patient Recruitments;Patient Selection;Patients;Physicians;Physicians' Offices;Play;Population;precision medicine;Prevalence;Principal Investigator;Process;Prostate;Publications;Puerto Rican;Puerto Rico;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;RNA;Role;Science;Services;Specimen;Surgeon;System;targeted treatment;Techniques;Tissue Donations;Tissue Microarray;Tissues;Training;transcriptome sequencing;Translation Initiation;translational cancer research;Underrepresented Minority;Universities;Urologist

PROJECT_TITLE: Puerto Rico BioBank Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: NEUROLOGY

PHR: Project Narrative This project aims to identify the extent to which two forms of prosocial engagements—formal volunteering carried out under the auspices of formal organizations and informal helping provided to friends and neighbors—lead to slower cognitive decline, and also uncover evidence on whether these helping behaviors serve as a buffer against adverse effects of genetic risks for Alzheimer's disease (AD) and disadvantaged neighborhood conditions. Findings from this project are expected to provide robust evidence for the linkage between helping behaviors and delayed cognitive decline and reduced AD risk, thereby informing empirically driven intervention approaches that promise a win-win-win proposition for those who engage in the helping behaviors, the persons helped, and the society.

PI_NAMEs: HAN, SAE HWANG  (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Acceleration;Address;Adverse effects;African American population;age related changes;Alzheimer's Disease;Alzheimer's disease risk;American;Attention;Attenuated;Baltimore;Behavior;behavior influence;biological systems;biopsychosocial;Buffers;Censuses;Cognition;Cognitive;Cognitive aging;cognitive benefits;Cognitive deficits;cognitive function;Communities;Data;Deterioration;Development;Disadvantaged;Dose;Economic Conditions;effective intervention;Effectiveness;Environment;Environmental Risk Factor;Epidemic;ethnic difference;European ancestry;evidence base;experience;Foundations;Friends;Funding;Future;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Goals;Health;Health and Retirement Study;Health behavior;Health Benefit;health data;Helping Behavior;high reward;high risk;Hispanic Americans;Hour;Impaired cognition;Individual;innovation;insight;Intervention;intervention program;Knowledge;late life;Lead;lifestyle factors;Light;Link;Literature;Modeling;modifiable risk;neighborhood disadvantage;Neighborhoods;Neurobiology;novel;older adult;Outcome;Pathogenesis;Pathway interactions;Persons;Policies;prevent;Public Health;public health intervention;racial difference;Randomized, Controlled Trials;Recording of previous events;Reporting;Research;Research Personnel;response;Risk Factors;Risk Reduction;Role;Skin;social;social capital;social engagement;Social isolation;Societies;Socioeconomic Status;socioeconomics;System;Theoretical model;Time;Trust;volunteer;Work

PROJECT_TITLE: Helping Behaviors and Cognitive Functioning in Later Life: Linkages with Genetic Risks for Alzheimer's Disease and Disadvantaged Neighborhood Socioeconomic Status

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: MANHATTAN

ORG_NAME: RADIATION DETECTION TECHNOLOGIES, INC.

ORG_STATE: KS

PHR: Project Narrative The high spatial-resolution and energy-resolution of cadmium telluride (CdTe) and cadmium zinc telluride (CZT), compared to that of scintillators, offers superior image quality in nuclear medicine and X-ray imaging applications. Unfortunately, the current state-of-the-art (i.e. Traveler Heater Method) for growing CdTe/CZT crystals is slow, expensive, and does not meet the demands of the current market needs. The Accelerated Crucible Rotation Technique (ACRT) has recently been applied to CdTe/CZT and has proved to be rapid-production process for growing high-performance CdTe and CZT crystals, a process that will change the current CdTe/CZT market by providing affordable, high-quality devices to stakeholders in the high-demand and growing medical imaging markets.

PI_NAMEs: FURENLID, LARS R;MCCLOY, JOHN S;MONTAG, BENJAMIN  (contact);SWAIN, SANTOSH KUMAR

PROGRAM_OFFICER_NAME: ASHMONT, KARI RICH

PROJECT_TERMS: Acceleration;bone;Businesses;cadmium telluride;CdZnTe;Chlorine;Clinical;Collection;Commercial grade;commercialization;cost;crystallinity;Densitometry;Dental;design;Detection;Devices;Diagnostic Imaging;Discipline of Nuclear Medicine;Gamma Rays;Government;Growth;Hour;Hybrids;Image;Imaging Device;imaging system;improved;Industrialization;Industry;instrumentation;interest;Laboratory Research;manufacture;Marketing;Medical;Medical Imaging;melting;Methods;next generation;Oncology;operation;Outcome;Pattern;Performance;Phase;Photons;Positron-Emission Tomography;Price;Process;Production;Property;prototype;Radiation;radiation detector;Radiation Dose Unit;Resolution;Roentgen Rays;Rotation;Security;System;Techniques;technological innovation;Temperature;Time;Travel;United States;United States National Institutes of Health;Validation;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: The Rapid-Production of the High-Performance and Affordable Cadmium Telluride and Cadmium Zinc Telluride for Medical Imaging Applications.


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research

PI_NAMEs: DUTIL, JULIE  (contact)

PROJECT_TERMS: Address;Admixture;analytical tool;ancestry analysis;Area;Big Data;biobank;Bioinformatics;Biometry;Cancer Center;cancer health disparity;Cell Line;cohort;Collaborations;Communication;Consent;Data;Data Analyses;Data Collection;data integration;data management;Data Scientist;design;Development;Disparity;DNA;Education;education research;Ensure;Environment;Evaluation;experience;Future;Genetic;Genome;genomic data;Genomics;Grant;Health Disparities Research;Health Sciences;high dimensionality;Hispanic;Hispanic-serving Institution;Improve Access;improved;Informatics;Infrastructure;infrastructure development;innovation;Institution;Latino;Latino Population;Lead;Life Cycle Stages;member;Molecular;Molecular Profiling;novel;Oncology;online resource;Online Systems;Participant;Phase;Physicians;precision medicine;Proteomics;Puerto Rico;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Support;Resources;Sample Size;Sampling;Science;Services;skills;software infrastructure;statistics;Students;synergism;System;The Cancer Genome Atlas;Tissues;tool;Training;transcriptome sequencing;Translations;Universities;Vision;Visualization software

PROJECT_TITLE: Quantitative Sciences Core


NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Regulations of stem cells and their microenvironments are altered in older age which lead to impaired damage repair and tissue regeneration in most animals examined. Here, we propose to use the cutting-edge spatial transcriptomic tools to identify changes in stem cells and their microenvironments in young and old planarians, and in the regeneration of new tissues in old planarians to facilitate our understanding of how an old planarian can regenerate a young eye. Such knowledge will help improve regenerative medicine in elderly patients.

PI_NAMEs: GUO, LONGHUA  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: adult stem cell;Age;Age related macular degeneration;age-related disease;aged;Aging;aging reversal;Animal Model;Animals;Architecture;Atlases;Body part;Cell Communication;cell type;Cells;Collaborations;Data;Data Set;Development;differential expression;Elderly;empowerment;experimental study;Eye;eye regeneration;fighting;Fresh Water;Gene Expression;Genes;Goals;Head;human old age (65+);Image;Impairment;improved;Knowledge;Laboratory culture;Learning;Methods;Molecular;molecular dynamics;Natural regeneration;next generation;older patient;Output;Pathway interactions;patient - derived stem cells;Patients;Pattern;Persons;Phenotype;Pigments;Planarians;Platyhelminths;Process;Production;progenitor;Quality of life;regenerative;Regenerative capacity;Regenerative Medicine;Regulation;Rejuvenation;repaired;Reporting;Research;Resolution;Signal Transduction;single cell mRNA sequencing;Slide;stem cell biology;stem cell function;stem cell technology;stem cells;Technology;theories;Therapeutic;tissue regeneration;Tissues;tool;transcriptome;transcriptomics;Work

PROJECT_TITLE: Imaging spatial transcriptome at single cell resolution to study eye regeneration in old age

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

PI_NAMEs: DIAZ OSTERMAN, CARLOS JOEL (contact)

PROJECT_TERMS: Address;Admixture;Affect;Aftercare;androgen deprivation therapy;Androgen Receptor;Automobile Driving;biobank;Biological Markers;black men;Black Populations;Black race;Blood specimen;Cancer Center;cancer health disparity;cancer initiation;Cancer Patient;cancer type;Castration;Cell Line;Cells;Cessation of life;chemotherapy;clinical risk;clinically relevant;cohort;Data;data registry;Development;differential expression;disease phenotype;Disease Progression;Disparity;DNA Methylation;DNA Methylation Inhibition;docetaxel;Drug Modelings;Drug resistance;drug sensitivity;Drug usage;enzalutamide;Epigenetic Process;epigenetic variation;Failure;Florida;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene therapy;Genes;Goals;health care availability;Health Sciences;high risk;Hispanic;Hispanic Populations;improved;Incidence;Indolent;Latino;Latino Population;liquid biopsy;Malignant neoplasm of prostate;Malignant Neoplasms;men;Methylation;methylation biomarker;methylation pattern;Molecular;Molecular Probes;mortality;neoplasm registry;Not Hispanic or Latino;novel;outcome disparities;patient oriented;Pattern;Pharmaceutical Preparations;Phase;Phenotype;Plasma;Play;Population;Populations at Risk;potential biomarker;Prediction of Response to Therapy;Prostate;prostate cancer cell line;Prostate Cancer therapy;Puerto Rican;racial disparity;racial population;Reporting;Research Project Grants;Resistance;response;Risk;risk stratification;Role;Sampling;Selection for Treatments;Series;Socioeconomic Status;targeted agent;taxane;The Cancer Genome Atlas;therapy resistant;Tissues;Treatment Failure;treatment response;tumor;Tumor Biology;tumor DNA;Universities;Validation;Work

PROJECT_TITLE: Epigenetic variations associated with aggressiveness in prostate cancer among Puerto Rican men


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Ovarian Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

PI_NAMEs: ARMAIZ-PENA, GUILLERMO N (contact)

PROJECT_TERMS: adaptive immunity;ADRB2 gene;Adrenergic Receptor;Anxiety;Aspirin;Attenuated;biobank;biobehavior;Biological;Biological Assay;bisphosphonate;Black race;Cancer Biology;Cancer Center;cancer risk;cancer survival;carcinogenicity;Carcinoma;Case Series;Case/Control Studies;Chronic stress;Clinical;Data;Development;Diagnosis;Disease;Distress;Dose;education research;Emotional;Enzyme-Linked Immunosorbent Assay;epidemiologic data;Epithelial ovarian cancer;ethnic disparity;ethnic diversity;Ethnic Origin;Evaluation;exome;experience;Future;Gene Expression;Gene Expression Profile;Genes;Goals;Health Sciences;high risk;Hispanic;Hormones;Hospitals;Human;Immune;immune function;Immune response;Immunity;Immunosuppression;improved;Infiltration;Inflammation;Inflammatory;Inflammatory Response;innovation;Intervention;Latina;Lead;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Mediating;Mental Depression;mouse model;Mus;Norepinephrine;Not Hispanic or Latino;novel;Outcome;outreach;ovarian cancer prevention;ovarian neoplasm;Pathway interactions;Patient Self-Report;Patients;pharmacologic;Pharmacotherapy;population based;Population Heterogeneity;Population Intervention;Population Study;prevent;Prevention strategy;Process;prospective;Prospective cohort;Prostaglandins;psychosocial;Puerto Rico;Race;racial disparity;racial diversity;Reporting;Research;Research Project Grants;Resources;response;restraint stress;Risk;Role;Sampling;Science;Serous;Services;Stress;Sympathetic Nervous System;systemic inflammatory response;Time;Tissues;transcriptome sequencing;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Tissue;Tumor-associated macrophages;tumorigenesis;Universities;Up-Regulation;Woman;Work

PROJECT_TITLE: The impact of biobehavioral factors and aspirin on ovarian cancer biology


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOLOGY

ORG_NAME: SAN FRANCISCO STATE UNIVERSITY

PHR: Cases of and deaths from most chronic diseases are disproportionally higher in communities of color. These health disparities are linked to chronic stress and the proposed research will gather knowledge about anti- racist healing in nature as a tool for stress reduction in BIPOC young adults. The culturally-appropriate, and affirming low-cost interventions that are developed will promote telomere growth to prevent health disparities.

PI_NAMEs: MARQUEZ-MAGANA, LETICIA MARIA (contact);TATE, CHARLOTTE

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Acceleration;Address;Adult;Age;anti-racism;Behavior;Biological;Biological Markers;Biological Process;Biomedical Research;Black race;Black, Indigenous, People of Color;Cell Aging;Cessation of life;children of color;Chronic Disease;Chronic stress;Cities;Collaborations;Color;Communities;community based participatory research;community engagement;community organizations;Conscious;coping;cost effective;County;culturally appropriate intervention;Data;Development;Discrimination;Disease;disease disparity;disorder risk;Economics;Education;efficacy evaluation;Elements;Employment;Ensure;Environment;Equity;Ethnic Origin;evidence base;experience;Goals;Government;Growth;Guidelines;healing;Health;Health Disparities Research;health disparity;health equity;Health equity research;health inequalities;Housing;Hydrocortisone;improved;innovation;insight;Institutionalization;Intervention;intervention cost;Knowledge;Latinx;Length;Life;Life Cycle Stages;Link;Measurement;member;microaggression;National Institute on Minority Health and Health Disparities;Nature;Outcome;outreach;Pacific Islander;pandemic disease;Participant;peace;Personal Satisfaction;Physical activity;Policies;Population;premature;prevent;preventive intervention;Primary Prevention;Privatization;Process;psychosocial;Public Health;Public Sector;Publishing;Race;racism;Recommendation;Recovery;recruit;Reduce health disparities;Research;Research Personnel;Research Priority;Resources;Risk;San Francisco;screening;Screening procedure;Secondary Prevention;Sister;social health determinants;Specialist;Stress;stress reduction;Students;synergism;System;Teenagers;telomere;Telomere Shortening;Testing;tool;transition to adulthood;Uncertainty;underserved community;United States;uptake;Visit;Walking;Work;young adult;Youth

PROJECT_TITLE: Examining Anti-Racist Healing in Nature to Protect Telomeres of Transitional Age BIPOC for Health Equity.


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: RAMOS-PIBERNUS, ALIXIDA G (contact)

PROJECT_TERMS: Active Learning;Address;assigned female at birth;Attitude;Automobile Driving;Behavior;Behavioral;Birth;Body part;Cancer Center;cancer health disparity;Caring;Cervical Cancer Education;cervical cancer prevention;Cervical Cancer Screening;cisgender;Clinical;Collaborations;Communities;Competence;Data;design;disease disparity;Disparity;effective intervention;Effectiveness of Interventions;effectiveness testing;Emotional;ethnic minority;Ethnic Origin;Ethnic Population;Exhibits;experience;Feasibility Studies;Florida;Fostering;Funding;Gender;gender affirmation;gender expression;Gender Identity;gender minority;Guidelines;health disparity;Health Knowledge Attitudes Practice;Health Personnel;Health Sciences;Healthcare;high risk;Hispanic Populations;implementation measures;implementation outcomes;implementation strategy;improved;Incidence;Individual;Interdisciplinary Study;intersectionality;Intervention;intervention effect;Interview;Knowledge;Latino Population;Latinx;male;Malignant neoplasm of cervix uteri;Malignant Neoplasms;man;Masculine;Measures;Medical Education;medical schools;Medical Students;Modeling;Nature;nonbinary;online intervention;Participant;Patient Self-Report;Patient Simulation;Patients;Persons;Politics;Population;Prevention;Prevention Guidelines;Provider;provider behavior;Puerto Rico;Randomized, Controlled Trials;Recommendation;Reduce health disparities;Research;Research Design;Research Personnel;Research Project Grants;screening;Screening for cancer;Services;simulation;skills;social;social cognitive theory;Standardization;Stigmatization;student training;Testing;theories;tool;transgender men;Treatment Efficacy;Universities;women patients;Work

PROJECT_TITLE: Fostering Cervical Cancer Screening Promotion for Latinx Trans Men Among Medical Students


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: SAAVEDRA, HAROLD I (contact)

PROJECT_TERMS: Accountability;Advanced Malignant Neoplasm;Advisory Committees;Area;Cancer Center;cancer health disparity;Cancer health equity;Collaborations;Collection;Communication;Community Outreach;Data;Development;Education and Outreach;effectiveness evaluation;Elements;Ensure;Evaluation;Evolution;Feedback;flexibility;Florida;Funding;Goals;Grant;Growth;Health Sciences;Hispanic;improved;Information Systems;innovation;Institution;Journals;Knowledge;Latino Population;Logic;meetings;member;Modeling;Monitor;National Cancer Institute;novel;Online Systems;Outcome;Output;Process;programs;Progress Reports;Publications;Puerto Rico;Recommendation;Research;Research Personnel;Research Project Grants;Resources;Science;special interest group;Strategic Planning;Structure;success;Surveys;Time;Universities;Update;Work

PROJECT_TITLE: Planning and Evaluation Core