ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Growing evidence suggests we can create privacy-respecting health datasets that are larger, more diverse, and more widely available through the integration of synthetic data produced by generative AI. However, it is currently unknown how best to appraise synthetic health data generation for the factors on which researchers need to trust (e.g., reliability of the data generated) and refine such technology to support equitable healthcare research and applications. This project will create a set of computational methods, realized in open-source software, to enable systematic evaluation of and multi-institutional development of synthetic health data, as well as the development of a fairness-aware medical AI pipeline through the integration of such data.

PI_NAMEs: YAN, CHAO  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Academic Medical Centers;Acceleration;Algorithms;All of Us Research Program;Architecture;arm;artificial intelligence algorithm;artificial intelligence model;Attention;Automobile Driving;Awareness;biomedical informatics;Biomedical Research;career;case control;Characteristics;Clinical;Clinical Trials;computer science;Computer software;Computing Methodologies;Coupled;Data;data quality;Data Set;data sharing;Data Sources;Dedications;design;Development;Diagnostic;digital;Dimensions;Discrimination;Doctor of Philosophy;effectiveness evaluation;Electronic Health Record;electronic structure;Ensure;Equilibrium;Equitable healthcare;Ethical Issues;Ethics;Evaluation;federated learning;Fostering;Generations;generative artificial intelligence;genomic data;Health;Health Care Research;health data;Health equity research;Healthcare;improved;Information Systems;innovation;Institution;Investigation;Knowledge;knowledge integration;large datasets;learning algorithm;Machine Learning;machine learning model;Measures;Medical;Medical Imaging;Medicine;Mentors;Methodology;Methods;Minority Groups;Modeling;multidisciplinary;multimodality;novel;open source;Outcome;Patient Care;Patients;Performance;personalized medicine;Placebos;Population;Population Heterogeneity;predictive modeling;preservation;Privacy;privacy preservation;privacy protection;Privatization;Process;Property;racial population;rare condition;Research;Research Personnel;Resources;Role;Source;Statistical Methods;Subgroup;synthetic data;Technology;tool;Training;treatment optimization;Trust;trustworthiness;Underrepresented Populations;United States National Institutes of Health;Variant;Vision;Work

PROJECT_TITLE: Generative AI for synthetic data: A framework to expand health data reach for research and ensure algorithmic fairness

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 AS-C (01)]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Narrative The biosynthesis of complex sugars is fundamental to bacterial survival and to the interactions between bacterial pathogens and symbionts and their human hosts. The proposed studies will uncover how a superfamily of enzymes, which is only found in bacteria, acts at bacterial membranes to carry out an initial, critical step in complex sugar assembly. Application of chemical biology, biochemistry, structural biology, and bioinformatics approaches will provide the community a deep understanding of the structures and functions in the enzyme superfamily and its roles in the interactions between both beneficial and injurious bacteria and their human hosts.

PI_NAMEs: ALLEN, KAREN N. (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Active Sites;Anabolism;analog;Anti-Bacterial Agents;Bacteria;Base Sequence;Binding;Biochemical;Biochemistry;Bioinformatics;Biological;Biological Assay;Biology;Biopolymers;bisphosphonate;carbene;cell envelope;Cell membrane;Cell Physiology;Chemicals;Classification;Communities;Complex;computer studies;Cryoelectron Microscopy;Cytoplasm;Dedications;design;Detergents;Development;Diphosphates;Electrostatics;empowerment;Enzymes;Epitopes;Escherichia coli;Face;Family member;Fingerprint;gene function;Genes;Genome;Glycoconjugates;glycosyltransferase;Goals;high throughput screening;Human;In Vitro;in vivo;inhibitor;inorganic phosphate;insight;Knowledge;Libraries;Ligands;lipid nanoparticle;macromolecule;member;Membrane;meter;Neighborhoods;nucleoside analog;nucleoside diphosphate;Nucleotides;Operon;Oxidoreductase;Oxygen;parallel computer;Pathogenesis;pathogenic bacteria;Pathway interactions;Phenotype;Play;Polysaccharides;prevent;protein folding;protein protein interaction;Proteins;Regulation;Resolution;Roentgen Rays;Role;S phase;Sequence Alignment;Sequence Analysis;small molecule;Solid;Specificity;structural biology;Structure;Substrate Specificity;sugar;sugar nucleotide;symbiont;synergism;Testing;therapeutic target;Thymidine;tool;Transferase;Uridine;Uridine Diphosphate Sugars;Virulence;Work;X-Ray Crystallography

PROJECT_TITLE: Structure and function of the monotopic phosphoglycosyl transferase superfamily: Initiators of biosynthesis of complex bacterial glycoconjugates

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Wildfires and human activities are leading to massive deforestation worldwide. Deforestation, as a sudden or expansive change, produces stress reactions that are highly associated with tobacco and alcohol use, yet the relationship has not been comprehensively studied. This proposed research examines how deforestation types and complex patterns over time relate to tobacco and alcohol use to inform future climate and health policies and reduce attributable population-level health burdens.

PI_NAMEs: CERNA-TUROFF, ILAN  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Affect;Agriculture;Alcohol consumption;Alcohols;Area;Attenuated;behavioral health;biological adaptation to stress;Biological Markers;California;career;Classification;climate-related health;Communities;Complex;Computer software;Consumption;cost;Country;Cross-Sectional Studies;Data;Deforestation;design;disability payment;Disproportionately impacts women;Dose;economic incentive;Education;Environment;environmental change;Environmental Epidemiology;Environmental Exposure;Environmental Health;environmental health disparity;environmental justice;Epidemiologist;Epidemiology;Exhibits;experience;Face;Factor Analysis;forest;Future;General Population;Geography;Goals;Growth;Health;Health behavior;Health Policy;Household;Human;Human Activities;Image;Imagery;improved;Individual;Indonesia;Intervention;Joints;Knowledge;Lead;Link;Literature;low and middle-income countries;Low income;member;Mental disorders;Mental Health;Methods;Mission;Modeling;Morbidity - disease rate;mortality;National Institute of Environmental Health Sciences;New York City;older adult;Outcome;palm oil;Pattern;Pharmaceutical Preparations;Phase;Physiological;Plants;Policies;Population;population health;Probability;Production;remote sensing;Reproducibility;Research;Resources;response;Risk;Science;simulation;social;spatiotemporal;Strategic Planning;Stress;Stress and Coping;Stressful Event;Subgroup;substance use;Time;Tobacco;Tobacco use;Training;trend;United States;Vision;Wildfire

PROJECT_TITLE: Spatiotemporal effects and associations between deforestation and alcohol and tobacco use in Indonesia

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-S (99)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Lung;Mental Health;Palliative Care;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Over 1.5 million patients are admitted to an intensive care unit (ICU) with acute respiratory failure each year in the United States, and survivors are often dependent on family caregivers due to severe, persistent health problems and complex medical needs following hospital discharge. Both acute respiratory failure survivors and their caregivers describe inadequate post-discharge support as a major barrier to patient recovery, and emerging evidence suggests that a family-centered intervention approach designed to meet the support needs of both patient and caregiver holds promise for improving long-term outcomes for acute respiratory failure survivors. This mentored patient-oriented research career development project will adapt and test a family- centered post-discharge support intervention to improve health outcomes for survivors of acute respiratory failure, which holds major public health relevance given the increase in acute respiratory failure survivorship due to COVID-19 and other severe, prevalent respiratory viruses.

PI_NAMEs: WENDLANDT, BLAIR N (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Active Learning;Acute Respiratory Distress Syndrome;Acute respiratory failure;Admission activity;Advisory Committees;Appointment;Award;Behavior Therapy;behavioral health intervention;Behavioral Sciences;care giving burden;career;career development;Caregiver Burden;Caregivers;Caring;Case Manager;Chaplain;Client satisfaction;Clinical Psychology;Clinical Research;Clinical Sciences;Clinical Trials;Communication;Complex;Conduct Clinical Trials;coping;Coping Skills;Couples;COVID-19;Critical Care;Data;Decision Making;Dedications;design;Development;Disease;Disease Management;Dyspnea;Environment;experience;Extramural Activities;Faculty;Family;Family Caregiver;Family member;family support;feasibility testing;Focus Groups;Friends;Funding;Goals;Health;health management;health related quality of life;Heart failure;Hospitals;Impaired cognition;improved;improved outcome;innovation;Intensive Care Units;Intervention;intervention delivery;Interview;Learning;Life;long term recovery;Lung;Lung Diseases;Malignant Neoplasms;Measures;Medical;Medication Management;Medicine;member;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Modeling;National Heart, Lung, and Blood Institute;Nature;North Carolina;Nurses;Outcome;Outpatients;Pain;Palliative Care;Participant;Patient Admission;Patient Care;patient engagement;patient oriented research;Patient-Focused Outcomes;Patients;Peer Review;Persons;physical conditioning;Physicians;pilot test;Pneumonia;preference;Prevalence;Principal Investigator;Procedures;Productivity;professor;programs;Prospective, cohort study;Psychiatry;public health relevance;Questionnaires;Randomized;randomized trial;randomized, clinical trials;Recovery;recruit;Research;research and development;Research Personnel;Research Priority;Research Project Grants;respiratory;Respiratory Failure;respiratory virus;response;Self Efficacy;Self Management;Series;Site;skills;Social Sciences;Social Workers;Structure;Survivors;survivorship;Symptom Burden;Telephone;telephone session;Testing;therapy design;tool;Training;Translational Research;Trauma;Uncertainty;United States;United States National Institutes of Health;Universities;Viral Respiratory Tract Infection;virtual;Work;Writing

PROJECT_TITLE: Adaptation and pilot testing of a family-centered intervention to improve long-term outcomes for survivors of acute respiratory failure

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (MA)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Cerebrovascular;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: KINGSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: SARS-2-CoV-2 (COVID-19) remains a highly endemic infectious disease in the U.S. and can cause serious cerebral vascular disease. Cerebral amyloid angiopathy (CAA) is a common cerebral small vessel disease and cause of stroke in the elderly. The purpose of this exploratory project is to evaluate how SARS-2-CoV-2 impacts the pathogenesis of CAA.

PI_NAMEs: VAN NOSTRAND, WILLIAM E. (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: 2019-nCoV;abeta accumulation;Acceleration;ACE2;Acute;acute stroke;Affect;aged;aging population;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Blood Coagulation Disorders;Blood Vessels;Brain;brain fog;Brain hemorrhage;Cerebral Amyloid Angiopathy;Cerebral hemisphere hemorrhage;Cerebral Infarction;cerebral microbleeds;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;Chronic;Communicable Diseases;comorbidity;COVID-19 patient;Dementia;Disease;disease model;Elderly;Elements;Endothelial Cells;Event;Future;Goals;Health;Hemorrhage;Hospitalization;Human;Impaired cognition;Infarction;Infection;Inflammation;Intervention;Investigation;Ischemia;Ischemic Stroke;Life;Link;Literature;Long COVID;Measures;Mediating;Meningeal;Modeling;Morbidity - disease rate;neuroinflammation;Neurologic Symptoms;novel;Organ;pandemic disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Phase;Population;Pre-Clinical Model;Prevalence;Proteins;Rat Transgene;Rattus;Reporting;Respiratory Disease;Risk;Risk Reduction;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Severities;Stroke;thrombotic;Time;transcriptomics;uptake;Vascular Diseases;Virus;Virus Diseases

PROJECT_TITLE: Impact of SARS-Cov-2 on a Rat Model Cerebral Amyloid Angiopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-E (90)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Substance Misuse

ORG_CITY: EAST LANSING

ORG_NAME: LABSYS, LLC

ORG_STATE: MI

PHR: PROJECT NARRATIVE Drawing from the urgent need to address the opioid crisis, our research aims to develop a wearable opioid sensor to continuously monitor drugs in body fluid for treatment of opioid use disorders. By facilitating personalized medication management and reducing the need for frequent clinic visits, this sensor can improve treatment adherence and accessibility, especially in underserved regions. The proposed technology has the potential to transform treatment protocols and patient monitoring, ultimately reducing fentanyl-related overdoses and fatalities.

PI_NAMEs: HUANG, YUE  (contact);WANG, ZHE

PROGRAM_OFFICER_NAME: KOSTOV, YORDAN VALTCHOV

PROJECT_TERMS: Address;Affect;Analytical Chemistry;Artificial skin;biomaterial compatibility;Blood;Body Fluids;Breakthrough device;Buprenorphine;Businesses;Clinic Visits;Clinical;Clinical Trials;Collaborations;commercialization;Complex;cost;cost effectiveness;Coupled;data exchange;design;Detection;detection method;Development;Devices;Disparity population;Drug Monitoring;electric impedance;Electrochemistry;Electrodes;empowerment;Engineering;Ensure;experience;fabrication;feasibility research;Fentanyl;Fostering;Gases;glucose monitor;glucose sensor;Goals;Health;high standard;Home;Human;Implant;improved;Individual;innovation;insight;integrated circuit;Intercellular Fluid;Interview;large scale production;Legal patent;Liquid substance;Longevity;manufacturability;Market Research;Marketing;Medication Management;Methadone;Methods;miniaturize;minimally invasive;Mission;Modeling;Monitor;monitoring device;Naltrexone;Needles;novel;Opioid;opioid epidemic;opioid use disorder;Outcome;Overdose;Painless;Patient Monitoring;patient safety;Patient-Centered Care;Performance;personalized approach;Persons;Pharmaceutical Preparations;Phase;product development;programs;prototype;Reaction Time;Reference Standards;Research;Resource-limited setting;Resources;Safety;Sampling;Secure;Sensitivity and Specificity;sensor;sensor technology;smart device;Specific qualifier value;Specificity;Spectrum Analysis;stem;System;Systems Integration;Techniques;Technology;Testing;Therapeutic;Time;Transplantation;treatment adherence;Treatment Effectiveness;Treatment Protocols;underserved area;Vision;wearable device;wearable platform;wearable sensor technology;wireless communication

PROJECT_TITLE: Wearable Continuous Drug Monitoring Device for Personal Medications in Opioid Use Disorders (CDM-MOUD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 CEM-S (M1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Neurosciences;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Improved understanding of the causal mechanisms of how early life socioenvironmental factors influence neurocognitive development and risk phenotypes for substance use disorder may help identify novel therapeutic targets. This application proposes to establish a multidisciplinary and functionally diverse team and generate preliminary data in rats towards improving our understanding of behavioral biomarkers and genetic risks factors of neurocognitive behaviors related to substance use disorder risk.

PI_NAMEs: BANKS, MATTHEW L;BOUNTRESS, KAITLIN ELIZABETH;HAMILTON, PETER JAMES;NEIGH, GRETCHEN N (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: addiction;Address;Adult;animal data;Applications Grants;Articulation;Behavior;Behavior Disorders;behavior prediction;Behavioral;Behavioral Genetics;Behavioral Model;behavioral outcome;behavioral phenotyping;Biological Markers;candidate identification;Cells;Childhood;Complex;Coupled;Critical Care;Data;Data Set;design;Development;discounting;Disease;disorder risk;Drug Addiction;Drug Modelings;Early identification;early life adversity;early life stress;Environment;Environmental Risk Factor;experimental study;externalizing behavior;Future;gene network;Gene Targeting;Generations;Genes;Genetic;Genetic Risk;genetic risk factor;genome wide association study;Genomics;Home;Housing;Human;improved;Impulsivity;Individual;Influentials;innovation;Investigation;Knowledge;Learning;Life;Link;Literature;Long-Evans Rats;low socioeconomic status;Measures;Mental disorders;Modeling;Molecular;multidisciplinary;multiple omics;Network-based;Neurocognitive;Neurocognitive Deficit;Neurosciences;new therapeutic target;novel;Obesity;Participant;Pathway Analysis;Performance;Phenotype;Physicians;polygenic risk score;pre-clinical;predicting response;Prefrontal Cortex;Psychological reinforcement;Rattus;Research;Resources;response;Risk;Risk Behaviors;Risk Factors;Rodent;Sensory;Social Environment;Socioeconomic Status;socioenvironmental factor;Stress;substance use;Substance Use Disorder;Techniques;Testing;transcriptome sequencing;transcriptomics;Translating;Translational Research;translational scientist;Trauma;United States National Institutes of Health;Universities;Virginia;Work

PROJECT_TITLE: Neurocognitive, genetic and socioenvironmental influences on a developmental precursors to addiction: A cross-species study

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 CEM-N (M1)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: In the United States, over 1.9 million patients annually are affected by acute respiratory failure, which makes it a common serious illness. As highlighted in recent NIH and National Academy of Medicine reports, there is a pressing need to identify and overcome the causes of health disparities in serious illness care, including how clinicians counsel patients and families about goals of care in advanced illness. This award will provide the principal investigator with the protected time, structure, and resources to mentor the next generation of clinician-scientists focused on developing strategies to achieve equity and improve outcomes for patients with acute respiratory failure.

PI_NAMEs: WHITE, DOUGLAS B (contact)

PROJECT_TERMS: Academy;Acute respiratory failure;advanced disease;Affect;Award;Black race;career;career development;Caring;Clinical;Collaborations;Communication;community engagement;Counseling;Critical Care;Critical Illness;Data;Data Set;Decision Making;disability;Disparity;diverse data;Doctor of Philosophy;Elements;end of life;Equity;Ethics;ethnic disparity;ethnic health disparity;Family;Funding;Goals;health care service utilization;Health Disparities Research;health disparity;Health Promotion;Health Services Research;Health system;improved;improved outcome;Individual;Infrastructure;innovation;Intervention;Intervention Studies;Latinx;Lead;Leadership;marginalization;marginalized population;Medical;medical schools;Medicine;Mentored Patient-Oriented Research Career Development Award;mentoring community;Mentors;Methodology;Methods;Mid-Career Clinical Scientist Award (K24);National Heart, Lung, and Blood Institute;next generation;Observational Study;Outcome;patient oriented;patient oriented research;Patient-Centered Care;Patient-Focused Outcomes;Patients;Pattern;Physicians;Positioning Attribute;preference;Principal Investigator;Prognosis;programs;provider communication;psychological distress;Public Health;Qualitative Research;racial disparity;racial health disparity;Reduce health disparities;Reporting;Research;research and development;Research Infrastructure;Research Personnel;Resources;Respiratory Failure;Science;Scientist;Senior Scientist;Series;Site;skills;Structure;surrogate decision maker;surrogate decision making;Testing;therapy development;Time;time use;Training;Trust;United States;United States National Institutes of Health;Universities;Voice;Work

PROJECT_TITLE: Mentored Patient Oriented Research in Improving Surrogate Decision Making for Patients with Advanced Respiratory Failure


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: Columbus

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Although the influence of social experiences on mental and physical health are commonly accepted, the biological drivers of these effects are not yet understood. Understanding the biological underpinnings of social modulation of neural health and behavior are critical to improved human health outcomes. This project is relevant to NIH’s mission because assessment of the effects of a common environmental factor underrepresented in research models will ultimately allow identification of novel intervention strategies to ameliorate adverse consequences of social disruption and lead to enhanced health and reduced disability.

PI_NAMEs: GLASPER, ERICA R (contact);NEIGH, GRETCHEN N

PROGRAM_OFFICER_NAME: JETT, DAVID ALAN

PROJECT_TERMS: adverse outcome;Alzheimer's disease related dementia;Behavior;Biological;Biology;Brain;California;disability;Disease;Environmental Risk Factor;experience;Health;healthy lifestyle;Human;Impairment;improved;Individual;Inflammation;Inflammatory;Inflammatory Response;Intervention;Link;Loneliness;Longevity;Mediator;Mental disorders;Mental Health;Metabolic;Mission;Mitochondria;Modeling;Mus;Nerve Degeneration;neural;neuroinflammation;novel;Outcome;Oxytocin;Pair Bond;Peromyscus;pharmacologic;physical conditioning;Physiological;psychologic;psychological outcomes;Quality of life;Research;response;Risk;Signal Transduction;social;social attachment;social engagement;social influence;Social isolation;social relationships;Social support;Stress;Synaptosomes;Testing;Translating;United States National Institutes of Health

PROJECT_TITLE: From Social Discruption to Neural Compromise: Establishing Markers and Mediators

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing novel and alternative therapies to treating patients with peripheral arterial disease (PAD). PAD, which affects approximately 8-10 million individuals in the US, is the leading cause of limb loss in the US. Despite significant improvements in medical and surgical therapies, the rate of limb loss continues to rise. Recently, the importance of skeletal muscle recovery to clinical outcomes in PAD has emerged as a new area of investigation and potential therapeutic strategy. The goal of this project is advance our understanding of the immune response to muscle injury in PAD patients. This is critical step for the future development of cellular therapies for limb preservation in PAD. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to reducing illness and disability.

PI_NAMEs: SOUTHERLAND, KEVIN WILLIAM (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Ablation;Address;Affect;Alternative Therapies;Amputation;Area;arterial lesion;Biology;Biopsy;Blood Vessels;career development;Cell Therapy;cellular development;cellular targeting;Chronic;Clinical;clinically significant;Coculture Techniques;Data;Development;disability;Disease;disease model;Disparate;experience;experimental study;Failure;Foundations;Future;Gene Expression Profile;Genetic Transcription;Goals;Heterogeneity;Hindlimb;Histologic;Human;Immune;Immune response;Immune system;Immunofluorescence Immunologic;Immunology;Immunotherapeutic agent;Immunotherapy;Impairment;improved;in silico;In Vitro;Individual;Infiltration;Inflammatory;Injury;innovation;insight;Institution;Intermittent Claudication;Investigation;Ischemia;Knock-in;Knock-out;Knowledge;Ligands;limb ischemia;limb loss;Limb structure;Link;Macrophage;Mediating;Medical;Mentors;Mission;Molecular;mortality;mouse model;Mus;Muscle;muscle progenitor cell;muscle regeneration;muscle repair;Myelogenous;Myeloid Cells;Myoblasts;Myopathy;Natural regeneration;novel;novel therapeutics;Operative Surgical Procedures;osteopontin;Outcome;Outcome Study;overexpression;Pathologic;Patients;Peripheral arterial disease;Phenotype;Play;Population;Positioning Attribute;pre-clinical;preservation;Process;professor;Program Development;programs;Public Health;Recovery;regenerative;repository;Research;Role;Scientist;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;skills;Specimen;Stains;stem cell self renewal;Surgeon;Testing;Therapeutic;therapeutic target;tibialis anterior muscle;Time;Tissue Banks;tissue repair;Training;transcriptomics;treatment strategy;trend;United States National Institutes of Health;Universities;Wild Type Mouse;Work

PROJECT_TITLE: Determining the Role of Spp1+ Macrophages in Muscle Regeneration in Peripheral Arterial Disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Osteoarthritis;Pain Research;Prevention

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on understanding vitamin K insufficiency (a modifiable risk factor) in knee osteoarthritis, which is a common cause of disability among older adults worldwide. Insights from the proposed research would lay the foundation for identifying an important OA phenotype targetable for testing vitamin K supplementation leading to disease modification, providing an important breakthrough for this disease in which there are no proven effective disease-modifying therapies available to date. Thus, the proposed research is relevant to NIAMS’ mission to support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases; and to support the training of basic and clinical scientists to carry out this research.

PI_NAMEs: LIEW, JEAN WAI (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Adherence;Adult;Affect;Alleles;Arthritis;Biochemical Markers;Biological Markers;Blood;Blood specimen;bone;Bone Marrow;career;Cartilage;Clinical;Clinical Trials Design;Data;Degenerative polyarthritis;dietary;disability;Disease;Dose;effective intervention;Enrollment;Environment;Epidemiologic Methods;Foundations;Funding;Future;genome wide association study;Goals;Hand Osteoarthritis;High Prevalence;high risk;improved;improved outcome;innovation;insight;Intake;interest;Intervention;Investigation;Knee;Knee Osteoarthritis;knee pain;Knowledge;Lesion;Link;Longitudinal cohort;Magnetic Resonance Imaging;matrix Gla protein;Measures;Mentors;Mentorship;mineralization;Mission;modifiable risk;Modification;Musculoskeletal;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;nutritional epidemiology;older adult;Outcome;Pain;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;Phenotype;Physical Function;physical impairment;Pilot Projects;pilot trial;Plasma;potential biomarker;prevent;Prevention;primary outcome;prospective;Public Health;radiological imaging;Research;Research Personnel;Research Support;Resources;Risk;Risk Factors;Role;Scientist;Serum;Severities;skin disorder;Structure;Subgroup;Supplementation;Symptoms;Synovitis;Testing;Therapeutic;Therapeutic Agents;Time;Training;Training Support;treatment effect;trial enrollment;United States National Institutes of Health;Vitamin K;Work

PROJECT_TITLE: The role of vitamin K in knee osteoarthritis outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M1)]


NIH_SPENDING_CATS: Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Osteoporosis;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: IOWA CITY

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The proposed research project aims to investigate the role of FGF21, a novel myokine, in Duchenne Muscular Dystrophy (DMD). The objectives of the study include understanding the mechanisms that lead to FGF21 expression in dystrophic muscle and examining how FGF21 contributes to the pathology of DMD, particularly in relation to muscle, bone, and whole-body metabolism. The project seeks to establish a foundation for comprehending the interactions between muscles and bones in the context of DMD, thus this work has the potential to shed light on the intricate mechanisms involved in DMD pathogenesis and may offer insights into novel therapeutic strategies.

PI_NAMEs: LI, HONGSHUAI  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Adipocytes;Adrenal Cortex Hormones;Affect;Agreement;bone;bone health;bone loss;Bone Marrow;bone mass;bone metabolism;bone quality;Bone Resorption;Cell model;Cells;Child;conditional knockout;Data;Disease Progression;Duchenne muscular dystrophy;effective therapy;Endocrine;FGFR1 gene;fibroblast growth factor 21;Foundations;Fracture;Generations;Glucocorticoids;glucose metabolism;Health;Homeostasis;improved;In Vitro;in vivo;insight;knockout animal;Knockout Mice;Knowledge;Lead;lipid biosynthesis;lipid metabolism;loss of function;Macrophage;Maps;Mediating;Metabolic;Metabolism;Mobility decline;Molecular;mouse model;Mus;Muscle;muscle degeneration;Muscle satellite cell;Muscular Dystrophies;muscular dystrophy mouse model;novel;novel therapeutic intervention;Obesity;osteoclastogenesis;Osteoclasts;Osteogenesis;Osteoporosis;Pathogenesis;Pathologic;Pathology;Patients;pharmacologic;Physiological;posttranscriptional;PPAR alpha;Protocols documentation;Quality of life;Recombinant Fibroblast Growth Factor;Reporter;Reporting;Research Project Grants;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;skeletal;skeletal abnormality;Skeletal Muscle;Source;standard of care;Stromal Cells;Structure;targeted treatment;Testing;Therapeutic;Work

PROJECT_TITLE: Role of FGF21 in DMD

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Kidney Disease;Precision Medicine

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Molecular imaging represents a paradigm shift that can improve clinical practice and health outcomes within nephrology. My interdisciplinary project aims to develop a new medical tool that can non-invasively detect, characterize, and quantify renal inflammation, thus promoting precision medicine for patients with kidney disease.

PI_NAMEs: POPPELAARS, FELIX  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acceleration;Advisory Committees;Antibodies;Binding;Biological;Biological Markers;Biology;Biopsy;career development;Caring;Cells;Clinical;clinical practice;Clinical Trials;Complement;Complement 3d;Complement Activation;Complement Inactivators;complement system;Cross Reactions;Data;Deposition;Detection;Development;diagnosis standard;Disease;Disease Marker;Disease Progression;Emission-Computed Tomography;Environment;Evaluation;Experimental Models;Extramural Activities;Faculty;Functional disorder;Funding;Future;Glomerulonephritis;Goals;Health;Heterogeneity;Histologic;Human;Image;imaging probe;Immunologics;Immunology;ImmunoPET;improved;in vivo;individualized medicine;Inflammation;Injury to Kidney;innovation;Institution;interest;International;Kidney;kidney biopsy;Kidney Diseases;Kidney Transplantation;Kinetics;Knowledge;Laboratories;Longitudinal Studies;Medical;member;Mentors;Mentorship;Methodology;Methods;Molecular;molecular imaging;Molecular Probes;Monitor;Monoclonal Antibodies;mouse model;multiple omics;Mus;Nephrology;Non-Invasive Detection;novel;Organ;Outcome;pathogen;Pathologic Processes;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Perfusion;personalized medicine;Phase;Plasma;Plasma Proteins;Positioning Attribute;Positron-Emission Tomography;Postdoctoral Fellow;precision medicine;Predisposition;Process;prognostic value;prognostication;Recording of previous events;Renal glomerular disease;Reporting;Research;Research Personnel;Research Project Grants;Role;Sampling;Sampling Errors;Scientist;Severities;skills;spatiotemporal;Staging;Stains;System;Talents;tenure track;Testing;Therapeutic;Time;Tissue imaging;Tissues;tool;Training;Translating;Translational Research;Treatment Effectiveness;treatment planning;treatment response;United States National Institutes of Health;Validation;Visualization;Visualization software;X-Ray Computed Tomography

PROJECT_TITLE: Noninvasive molecular imaging of complement biomarkers in kidney disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: Overall Project Narrative. Montana is one of the most rural states in the US, resulting in numerous health disparities that impact our underserved populations. In collaboration with our Partner Organizations, the Montana Clinical and Translational Research Center will build clinical and translational (C&T) research capacity that includes developing the C&T workforce, expertise, and infrastructure in Montana as we directly address the numerous health problems in our state.

PI_NAMEs: WARD, TONY JOHN (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Address;Adoption;Award;bench to bedside;Center for Translational Science Activities;Centers for Population Health;Clinical;clinical development;Clinical Investigator;Clinical Research;clinical research site;Collaborations;Communication;Communities;community engagement;Community Outreach;community setting;Consultations;Country;data management;design;Development;Discipline;Electronic Health Record;Evaluation;experience;Face;Funding;Funding Mechanisms;Goals;Health;health care settings;health disparity;Healthcare;Human;improved;Infrastructure;Investments;Laboratories;Letters;member;Mentorship;Methods;Montana;Nature;Network Infrastructure;outcome disparities;Persons;Pilot Projects;Population;practice-based research network;programs;Public Health;Public Health Education;Research;research and development;Research Design;Research Personnel;Research Project Grants;Resources;Role;Rural;rural area;rural dwellers;Rural Population;Testing;Training;Translating;Translational Research;translational scientist;Tribal group;tribal health;Tribes;underserved area;Underserved Population;United States National Institutes of Health;Universities;urban area;webinar

PROJECT_TITLE: The Montana Clinical and Translational Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (CD)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health

PROJECT_TERMS: Advisory Committees;Award;Benchmarking;Budgets;Center for Translational Science Activities;Clinical;clinical development;Clinical Research;Communication;Community Outreach;Data Collection;design;Development;Effectiveness;Evaluation;experience;flexibility;Funding;Goals;Grant;Health;improved;Individual;Infrastructure;innovation;Laboratories;Laboratory Research;meetings;Mentorship;Methods;Monitor;Montana;Needs Assessment;Occupational activity of managing finances;Performance;Population;Program Evaluation;programs;Reporting;Research;Research Personnel;Rural;rural area;Schedule;success;Testing;timeline;Training;Translational Research;translational scientist;underserved area;Universities;ward;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: NEWCOMER, SOPHIA RAFF (contact)

PROJECT_TERMS: Address;Advisory Committees;Affect;Award;Center for Translational Science Activities;Clinic;Clinical;clinical application;Clinical Investigator;Clinical Research;cohort;Collaborations;college;Country;data management;Data Sources;Development;Discipline;Ensure;experience;Extramural Activities;Funding;Goals;Grant;Health;Health Benefit;health disparity;health goals;health organization;Health Priorities;Human;improved;Joints;K-Series Research Career Programs;Lead;Link;Mentors;Mentorship;Monitor;Montana;novel;Osteopathic Medicine;Pediatric Hospitals;Population;Process;programs;Public Health;recruit;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;research study;Rural Population;Services;Training;translational applications;Translational Research;translational scientist;Universities;Work

PROJECT_TITLE: Health Research Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: NOONAN, CURTIS WILLIAM (contact)

PROJECT_TERMS: Academic Medical Centers;Accreditation;Address;Assessment tool;Center for Translational Science Activities;Clinical;clinical practice;Clinical Research;Collaborations;Communities;Coupled;design;Development;Development Plans;Discipline;Educational workshop;Ensure;Faculty;Failure;Funding;Funding Opportunities;Goals;Grant;Health Occupations;Health Personnel;improved;Individual;Mentors;Mentorship;Modality;Montana;Needs Assessment;Patients;Persons;Physicians;Population;Positioning Attribute;Preparation;programs;Public Health Education;Research;Research Personnel;Resources;Services;Site;skills;Structure;success;Training;training opportunity;Training Programs;Translational Research;translational scientist;Universities;Update

PROJECT_TITLE: Professional Development Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dissemination and Implementation Research

PI_NAMEs: CHASE-BEGAY, DAMIAN M (contact)

PROJECT_TERMS: Address;Center for Translational Science Activities;Clinical;Clinical Investigator;clinical practice;Clinical Research;cohort;Communities;community advisory board;community engaged intervention;community engaged research;community engagement;Community Outreach;Community Practice;COVID-19 pandemic;design;Development;Disparity;Dissemination and Implementation;diversity and inclusion;Faculty;Future;Goals;Health;health assessment;health care service organization;Health Priorities;Health system;implementation strategy;improved;Individual;innovation;Knowledge;Lead;Leadership;member;Mentors;Methods;Modeling;Montana;Outcome;outreach;Participant;Policies;Population;population health;Population Heterogeneity;Practice based research;practice-based research network;Process;Provider;Public Health;Public Health Practice;recruit;Research;research data dissemination;Research Personnel;Research Priority;Research Project Grants;research study;Resources;safety net;Site;skills;success;sustainability framework;therapy development;tool;Training;Translating;translational framework;Translational Research;translational scientist;Update;Work

PROJECT_TITLE: Community Engagement and Outreach Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SEMMENS, ERIN O'BRIEN (contact)

PROJECT_TERMS: Address;Adherence;Area;Attention;Biometry;Center for Translational Science Activities;Centers for Population Health;Centers of Research Excellence;Child Health;Childhood;Clinical;Clinical Investigator;Clinical Research;Clinical Trials Network;Collaborations;Communities;Data;data access;Data Analyses;data management;data modeling;Data Set;Data Sources;Dedications;design;Development;Electronic Health Record;Ensure;Epidemiology;Ethics;experience;Fostering;Funding Opportunities;Future;Goals;Guidelines;Health;health data;health disparity;Health Priorities;Health protection;Human;Infrastructure;Institution;Institutional Policy;Methodology;Montana;Outcome;Participant;Pathway interactions;Phase;Policies;Population;Procedures;programs;protocol development;Protocols documentation;Qualitative Research;recruit;Reporting;repository;Reproducibility;Research;research and development;Research Design;research facility;Research Personnel;Research Priority;Resources;Rural;Site;success;Surveys;tool;Training;Translational Research;translational scientist;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Research Design, Compliance, and Data Management Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioids;Social Determinants of Health;Substance Misuse

ORG_NAME: VITAN-BIOTECH, LLC

PHR: Project Narrative Substance Use Disorders (SUD) has become a major public health crisis in the United but many patients often encounter significant barriers to receiving a diagnosis and treatment for SUD due to lack of devices for rapid and low-cost quantitative measurement of drug concentrations and their metabolites for monitoring the compliance and metabolism of SUD medication drugs. If funded, this proposed project will fill current technology void in developing a low-cost, point-of- use, highly sensitive and specific non-instrument test that enables the convenient monitoring SUD therapy.

PI_NAMEs: ZHOU, XICHUN  (contact)

PROJECT_TERMS: Achievement;Acute;Address;amyloid precursor protein processing;Antibodies;Architecture;Benchmarking;Biological Assay;Buprenorphine;Cannabis;Cellular Phone;Clinic;Clinical;cohort;commercialization;computerized data processing;cost;Data;design;Detection;detection limit;detection sensitivity;Development;Devices;Diagnosis;Dose;drug testing;Ensure;Enzyme-Linked Immunosorbent Assay;Funding;Future;handheld mobile device;Home;Human;Image;innovation;Label;Laboratories;large scale production;lateral flow assay;Libraries;Licensing;manufacture;manufacturing process;Measurement;Measures;Metabolism;Methadone;Monitor;naltrexol;Naltrexone;nanoparticle;novel;Opiate Addiction;Pain management;Patients;Peptide Phage Display Library;Peptides;Performance;Pharmaceutical Preparations;Phase;Population Density;Preparation;prevent;Production;prototype;Provider;Public Health;Reader;Reagent;Resource-limited setting;rural area;salivary assay;Sampling;Signal Transduction;Specificity;Structure;Substance Abuse Treatment Centers;Substance Use Disorder;substance use treatment;Tail;Technology;Test Result;test strip;Testing;Training;urban area;Urine;Validation;Visit;waiver;wireless communication

PROJECT_TITLE: Field-Deployable, low-Cost Point-of-Need urine test strips for mobile quantification of SUD medication drugs and their metabolites


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: GALVESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE  In Alzheimer’s disease (AD), predictable spreading of tau pathology between functionally connected brain regions correlates well with progressive cognitive impairment, thus constituting a likely effective treatment target. The proposed study will evaluate the molecular mechanisms of pathological trans-synaptic tau spreading within the framework of selective cellular, regional, and clinical vulnerability. Specifically, the results of this investigation will contribute to the fundamental knowledge about the molecular mediators of tau oligomer binding and internalization in human synapses, thus providing novel and translationally relevant avenues for future AD research.

PI_NAMEs: TAGLIALATELA, GIULIO  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TITLE: Selective vulnerability and resilience to trans-synaptic pathological tau spreading in Alzheimers disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative This Midcareer Investigator K24 award in Patient Oriented Research will provide the principal investigator with protected time to mentor early-stage investigators in cardiovascular research within the mission areas of interest to the NHLBI. In particular, this award will focus on understanding trajectories of cardiovascular disease risk in adolescents and young adults and identify potential populations who would benefit from interventions to optimize their cardiovascular risk.

PI_NAMEs: KU, ELAINE  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Achievement;Adhesives;Adolescent;Adolescent and Young Adult;Adult;Advisory Committees;Age Years;Ambulatory Blood Pressure Monitoring;American Heart Association;Area;authority;Award;Big Data;Biometry;Blood Pressure;blood pressure control;Blood Pressure Monitors;California;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career;Caring;Cause of Death;Chest;Child;Childhood;Cholesterol;Chronic Kidney Failure;Clinic;Clinical;Clinical and Translational Science Awards;Clinical Research;cohort;comorbidity;Continuity of Patient Care;Data;data access;data registry;Data Set;Databases;Dedications;design;Devices;Diabetes Mellitus;Diagnosis;digital;digital health;Disease;Electronic Health Record;End stage renal failure;Ensure;Environment;Epidemiology;epidemiology study;experience;Exposure to;Failure;Family;Feedback;Funding;Glomerulonephritis;Glucose;Glycosylated hemoglobin A;Goals;Guidelines;Health;health disparity;Healthcare;Healthcare Systems;Heart Rate;Hematology;high risk;high-risk adolescents;Home;Home Blood Pressure Monitoring;Hour;Hypertension;implementation barriers;improved;Individual;individualized medicine;Infrastructure;inhibitor;Institution;interest;Intervention;Joints;Kidney Diseases;Leadership;Learning;Machine Learning;Masks;Measures;Medicine;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);Mission;Modification;multidisciplinary;National Heart, Lung, and Blood Institute;Natural Language Processing;Nature;Nephrology;novel;older patient;outcome disparities;parental involvement;patient oriented research;Patients;Pattern;pediatric patients;Performance;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;Principal Investigator;programs;Provider;Recommendation;Recording of previous events;Renin-Angiotensin-Aldosterone System;Research;Research Design;Research Personnel;Research Training;Resources;Risk;Risk Factors;Risk Reduction;risk/benefit ratio;San Francisco;Scholars Program;Secure;Self Management;side effect;skills;Sodium;success;symporter;Testing;therapy design;Time;Tobacco use;tool;Training;training opportunity;Training Programs;transmission process;Universities;Urology;Work;young adult;Youth

PROJECT_TITLE: Cardiovascular risk reduction in adolescents and young adults with kidney disease


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PUBLIC HEALTH RELEVANCE/PROJECT NARRATIVE Understanding what lifestyle health behaviors protect against cognitive decline and risk of Alzheimer's disease and related dementias is critical for prevention. This project will pool and harmonize participant-level data from existing trials to examine how changes in lifestyle health behavior impact cognitive outcomes across diverse older adults. Results from this research will inform clinical and public health guidelines focused on realistic changes in lifestyle health behaviors to protect against risk of cognitive decline across diverse populations.

PI_NAMEs: HALLOWAY, SHANNON  (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Adult;Age;Aging;aging brain;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;approach behavior;Area;Behavior;behavior change;Behavioral;Biological;Cardiometabolic Disease;Clinical;Cognition;Cognitive;cognitive function;cost effective;Data;data de-identification;data harmonization;Data Pooling;Data Set;Dementia;deprivation;Education;Episodic memory;ethnic minority;Ethnic Origin;executive function;Exposure to;good diet;Guidelines;Health;Health behavior;Health behavior change;health determinants;high risk;Impaired cognition;Incidence;indexing;Influentials;innovation;insight;late life;Letters;Life;Life Style;lifestyle intervention;Methodology;Methods;mild cognitive impairment;National Institute on Aging;Observational Study;older adult;Older Population;Outcome;Participant;Physical activity;Population;Population Heterogeneity;Prevention;primary outcome;prospective;Public Health;public health relevance;Race;racial minority;Randomized, Controlled Trials;Research;response;Risk;Role;Rural;Sampling;secondary outcome;sex;Shapes;social;social determinants;social health determinants;Speed;structural health determinants;Subgroup;Testing;theories;Time;Underrepresented Populations;United States National Institutes of Health;Work;World Health Organization

PROJECT_TITLE: Impact of change in lifestyle health behaviors on cognition: Harmonizing and leveraging participant-level data from randomized controlled trials

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Digestive Diseases;Genetics;Human Genome;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Benzimidazoles (BZ) are the treatment of choice for ascariasis in humans, but the development of resistance is a significant risk, as seen in other ascarids of veterinary importance. Mechanisms of resistance in ascarids are unknown but appear to differ from other nematode species. Therefore, we propose to develop an experimental system that will enable the identification of novel BZ resistance genes in ascarids of poultry as a model, allowing for clinical diagnosis of resistant ascarids and improving the quality of care and life of people in the developing world.

PI_NAMEs: ANDERSEN, ERIK CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Accounting;Affect;Albendazole;Alleles;Anthelmintics;Antiparasitic Agents;Ascariasis;Ascaridia;Ascaris lumbricoides;Ascaris suum;Back;Backcrossings;benzimidazole;benzimidazole resistance;beta Tubulin;Binding;Biological Models;Birds;Caenorhabditis elegans;Candidate Disease Gene;candidate identification;Chickens;Chromosome Mapping;clinical diagnosis;comparative genomics;cost;Data;Development;Diagnostic;disability-adjusted life years;Disease;Domestic Fowls;Drug resistance;Drug usage;economic impact;Embryo;Equus caballus;Ethical Issues;Evolution;Family suidae;Future;Generations;Genes;Genetic;Genetic Crosses;Genetic Predisposition to Disease;Genetic study;genetic variant;Genome;genome-wide;Genomic Segment;Genomics;Haemonchus;health economics;Helminths;Hookworms;Human;improved;Individual;Infection;innovation;insight;Life;Livestock;Maps;Methods;Microtubule Polymerization;Modeling;Morbidity - disease rate;Mutation;Nematoda;novel;Parasites;Parasitic nematode;Parents;Persons;Pharmaceutical Preparations;Phenotype;Predisposition;pressure;Probability;programs;Quality of Care;Quality of life;Quantitative Genetics;Recombinants;reference genome;Reporting;Research;Resistance;Resistance development;resistance gene;resistance mechanism;response;Risk;Ruminants;sex;socioeconomics;Soil;Study models;System;Techniques;telomere;transcriptome sequencing;Translating;transmission process;Transplantation;treatment choice;treatment program;Turkey bird;Variant

PROJECT_TITLE: Investigating the genetics and genomics of antiparasitic drug responses in a poultry model of ascariasis

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE We have developed a brain-penetrant, small molecule drug candidate, called MW189, that targets dysregulated inflammation and attenuates brain dysfunction. The proposed project will fill the remaining gaps necessary to bring MW189 to a future clinical study in Alzheimer’s patients. MW189 has the potential to be a first-in-class disease-modifying therapy for Alzheimer’s disease and related disorders.

PI_NAMEs: VAN ELDIK, LINDA J;WATTERSON, DANIEL MARTIN (contact)

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Administrative Supplement;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapy;analytical method;Applications Grants;Attenuated;Award;Brain;brain dysfunction;Budgets;Canis familiaris;Categories;Chemistry;Clinical Pathology;Clinical Research;Coenzyme A;cost;Cost Control;cost estimate;COVID-19 pandemic;Data Set;Disease;Dose;drug candidate;Drug Formulations;Funding;Future;Government Agencies;Grant;Histopathology;Human Resources;Inflammation;Length;lot production;manufacture;manufacturing capabilities;manufacturing cost;method development;Oral;pandemic disease;Pharmaceutical Preparations;Phase;post-COVID-19;Production;Public Health;Rattus;Recovery;Reporting;Rodent;Sampling;Schedule;small molecule;stability testing;supply chain;Testing;Time;Toxic effect;Toxicokinetics;Toxicology;Training;Update

PROJECT_TITLE: GMP Production and Extended Toxicology of an Oral Formulation Drug for Alzheimer's Disease


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lupus;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: PROJECT NARRATIVE The objective of this Mentored Patient-Oriented Research Career Development Award is to determine the contributions of social determinants of health to the risk of adverse pregnancy outcomes in systemic lupus erythematosus, while gaining the skills and training to become an independent investigator. By skillfully integrating diverse data sources, we will identify the most meaningful social determinants of health that contribute to adverse pregnancy outcomes risk in patients with systemic lupus erythematosus both at an individual and community level. This innovative approach combines clinical factors with social determinants of health and stakeholder feedback to create a synthesis that will streamline the identification of at-risk patients, with the long-term goal of mitigating health disparities and improving pregnancy outcomes for those grappling with this disease.

PI_NAMEs: MEHTA, BELLA  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: adverse pregnancy outcome;Affect;African American;African American population;care outcomes;career development;Censuses;Cerebrovascular Disorders;Clinical;Code;cohort;Communities;Complex;Data;Data Set;Data Sources;Databases;density;Disease;Disparity;diverse data;Early identification;Ethnic Origin;experience;Feedback;Female of child bearing age;fetal;Fetal Mortality Statistics;food insecurity;Foundations;Future;General Population;Geography;Goals;Health Care Costs;health care disparity;health data;Health Disparities Research;health disparity;Health Policy;Health Surveys;high risk;Hospitals;Household;housing instability;Immigrant;improved;improved outcome;Income;Individual;individual patient;Inequity;innovation;Inpatients;Institution;Internal Medicine;Internet;Intervention;Interview;K-Series Research Career Programs;Kidney Failure;Low income;Lupus;Machine Learning;machine learning method;maternal morbidity;Maternal Mortality;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Morbidity - disease rate;multidimensional data;Musculoskeletal;Neighborhoods;New York;novel;Patients;Performance;Play;Policies;predictive tools;Pregnancy;Pregnancy Outcome;pregnant;primary outcome;programs;prospective;Prospective cohort;Qualitative Methods;Qualitative Research;Race;racial disparity;Recommendation;Reduce health disparities;Reporting;Reproductive Health;Research;Research Personnel;Rheumatism;rheumatologist;Risk;Risk Estimate;risk prediction;risk stratification;Role;Safety;Salmon;Sample Size;Sampling;secondary outcome;skills;social;social health determinants;Social Workers;stakeholder perspectives;Study Skills;supervised learning;Systemic Lupus Erythematosus;Testing;Therapeutic;Training;Transportation;United States;United States Centers for Medicare and Medicaid Services;US State

PROJECT_TITLE: Deconstructing Disparities in Lupus Pregnancies

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Pediatric;Recovery Support Services;Rehabilitation;Rural Health;Substance Misuse

ORG_CITY: BLOOMINGTON

ORG_NAME: CHESTNUT HEALTH SYSTEMS, INC.

PHR: PROJECT NARRATIVE  The proposed Diversity Supplement: Leveraging Parents and Peer Recovery Supports to Increase Recovery Capital in Emerging Adults with Polysubstance Use: Feasibility, Acceptability, and Scaling Up of Launch (R34DA057639) will provide funding support for Dr. Castedo de Martell, a Hispanic woman with direct lived experience of substance use disorder, to complete two research activities that enhance the aims of the parent grant, and to receive intensive training and mentorship to advance to an independent research career. The overarching purpose of the Launch parent grant study is to assess the feasibility and acceptability of an innovative substance use services package, Launch, that leverages supportive parents and peer recovery support services to reduce poly-substance use and increase recovery capital in this critical developmental stage using quantitative, qualitative, and community-based participatory research procedures. The Diversity Supplement research activities will (1) prepare a cost-effectiveness analysis to accompany a future large scale Launch research project, and (2) will investigate recovery capital factors impacting peer workers’ ability to deliver services with fidelity, as well as expanding to peer workforce retention outcomes.

PI_NAMEs: DRAZDOWSKI, TESS K. (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: acceptability and feasibility;Adherence;Capital;career;community based participatory research;contingency management;cost effectiveness;Cost Effectiveness Analysis;Dedications;Development;economic outcome;Education;emerging adult;Funding;Future;Helping to End Addiction Long-term;Hispanic Women;improved;informant;innovation;Intervention;Interview;Leadership;Life;Lived experience;Mentorship;Methods;Modeling;Names;National Institute of Drug Abuse;Online Systems;Opiate Addiction;Opioid;opioid misuse;Outcome;parent grant;Parents;Participant;Patient-Focused Outcomes;peer;peer recovery;Policy Maker;polysubstance use;Procedures;Protocols documentation;Provider;Public Health;Randomized;Recovery;recovery services;Recovery Support;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Risk Reduction;Rural;scale up;Scientist;service gap;Services;Site;skills;Specific qualifier value;Speed;substance use;Substance Use Disorder;tool;Training;United States National Institutes of Health;uptake;Vocation;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Dementia;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE The accumulation of misfolded proteins represents a common feature in age-related neurodegenerative diseases, such as Huntington's disease. This project aims to uncover the role of specific molecular chaperones in neurons in mitigating protein aggregation in Huntington's disease. These findings hold the promise of guiding therapeutic strategies that harness the appropriate molecular chaperones to alleviate protein aggregation in Huntington's disease and potentially other neurodegenerative disorders.

PI_NAMEs: RAMANI, BISWARATHAN  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;age related neurodegeneration;Alzheimer's Disease;Amyloid;Amyotrophic Lateral Sclerosis;Area;Ataxia;beta pleated sheet;Bioinformatics;Biological Assay;career development;Cells;Client;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;CRISPR screen;Dedications;Dependovirus;Development;Development Plans;Discipline;Disease;disease phenotype;Disease Progression;empowerment;Environment;experimental study;functional genomics;Genetic Transcription;Goals;Grant;Hereditary Disease;Human;Huntington Disease;In Situ;In Vitro;in vivo;Induced pluripotent stem cell derived neurons;Inherited;insight;knock-down;Knowledge;Laboratories;Ligation;Link;loss of function mutation;member;Mentors;Mentorship;Microscopy;misfolded protein;Modeling;Molecular;Molecular Chaperones;Motor Neurons;mouse model;multidisciplinary;mutant;Nerve Degeneration;Neurodegenerative Disorders;neuronal survival;Neurons;neuropathology;Outcome;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Phenotype;Physicians;Play;polyglutamine;prevent;programs;protein aggregation;protein folding;protein misfolding;protein reconstitution;protein TDP-43;Proteins;Proteomics;proteostasis;Reporter;Research;Resources;Role;Scientific Advances and Accomplishments;Scientist;skills;Spinal;Spinocerebellar Ataxias;statistics;Stretching;Structure;tau Proteins;TDP-43 aggregation;Techniques;Technology;Testing;Therapeutic;therapeutic target;Tissues;Toxic effect;Training;Work;Writing

PROJECT_TITLE: Unraveling the role of the molecular co-chaperone DNAJC7 in protein homeostasis and neurodegeneration

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE The goals of the proposed research are to develop and pilot test a patient-centered, pediatric clinic-based postpartum contraception intervention that will promote equitable access to care. The relevance of this research to public health lies in its potential to transform perinatal maternal and child health services to better meet women’s postpartum contraceptive needs, and to therefore improve related health and social outcomes for women and families. This research aligns with NICHD research objectives, including setting a foundation for healthy pregnancies, improving child health, and the cross-cutting topic of health disparities.

PI_NAMEs: CONGDON, JAYME  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;antenatal;Birth Intervals;Caring;Child;Child Health;Childhood;Clinic;Clinical;Cluster randomized trial;community engagement;contextual factors;Contraceptive Agents;Contraceptive methods;Counseling;Data;Development;digital tool;Discipline of obstetrics;Disparity;Education;Effectiveness;effectiveness testing;Equity;evidence base;experience;Face;Family;Family Planning;Family Planning Education;Focus Groups;follow-up;Foundations;Future;Goals;Health;health disparity;health equity;health equity promotion;health inequalities;health outcome disparity;Health Promotion;Health Services;Health Services Accessibility;healthy pregnancy;high risk;implementation outcomes;implementation science;improved;Infant;Infant Care;Interdisciplinary Study;Intervention;Intervention Studies;Interview;life span;Low income;Maternal Health;Maternal-Child Health Services;Measures;Medical Care Team;member;Methods;Modeling;Morbidity - disease rate;mortality;Mothers;National Institute of Child Health and Human Development;novel;Outcome;patient oriented;Patient-Centered Care;Patients;pediatrician;Perinatal;perinatal complications;perinatal outcomes;Physicians;Pilot Projects;pilot test;post intervention;postpartum contraception;Postpartum Period;Postpartum Women;pragmatic trial;preference;Pregnancy;Pregnancy Interval;pregnancy prevention;Premature Birth;prevent;Prevention;primary care clinic;Provider;Public Health;Qualitative Methods;Reporting;reproductive;Reproductive Health;Research;Risk;Scientist;screening;Services;social;Social Impacts;Social outcome;Structure;Surveys;System;Testing;theories;therapy design;therapy development;Training;uptake;usability;Visit;Well Child Visits;Woman;women of color;women's outcomes;Work

PROJECT_TITLE: Integrating Maternal and Child Health Services: Development and Pilot Testing of a Pediatric Clinic-Based Postpartum Contraception Intervention

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Tobacco

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PUBLIC HEALTH IMPACT STATEMENT Preventive vaping interventions are critically needed that target the unique multilevel risk and protective factors of urban Indigenous youth; however, no such evidence-based interventions currently exist. The proposed study will test if a youth intervention can prevent nicotine and cannabis vaping for urban Indigenous youth. This research should provide important information that can be used to prevent and reduce vaping disparities among urban Indigenous youth and the downstream harmful impact on health disparities.

PI_NAMEs: AYERS, STEPHANIE LYNN (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Address;Adolescent;Adult;Age;alcohol and other drug;Arizona;Biological Models;Cannabis;Characteristics;Cigarette;cigarette smoking;Collaborations;combustible cigarette;Communities;community engaged research;community partners;community partnership;Complex;cost;cultural values;Decision Making;design;deter alcohol use;Discrimination;Disparity;Ecosystem;efficacy testing;efficacy trial;Electronic cigarette;Ensure;Epidemic;ethnic disparity;ethnic identity;Ethnic Origin;Ethnic Population;evidence base;Evidence based intervention;experience;Face;Focus Groups;Funding;Geography;Goals;Health;health disparity;High Prevalence;high risk;implementation barriers;implementation facilitators;implementation outcomes;Indigenous;indigenous community;Individual;insight;Intervention;junior high school;Knowledge;Legal;Lived experience;marginalized community;marijuana use;marijuana vaping;Misinformation;Modeling;National Institute on Minority Health and Health Disparities;Native-Born;Needs Assessment;Nicotine;nicotine use;Parents;Perception;permissiveness;Prevalence;prevent;Prevention;Preventive;preventive intervention;Problem Solving;Process;Proctor framework;protective factors;Public Health;racial disparity;racial identity;racial population;Recreation;Reduce health disparities;reduced alcohol use;Reporting;Research;Resistance;Risk;Risk Assessment;Risk Factors;Science;skills;Specificity;substance use;substance use prevention;success;Surgeon;Taxonomy;Testing;Time;trend;Tribes;United States National Institutes of Health;Urban Community;urban health disparities;urban setting;vaping;vaping nicotine;Work;Youth

PROJECT_TITLE: Leveraging Community-Engaged Research to Co-Create Youth Vaping Prevention with Urban Indigenous Communities of the Southwest

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKM-E (M1)]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Heart Disease;Neurodegenerative;Neurosciences;Stroke

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Cardiac arrest occurs in up to 600,000 adults per year in the United States and often leads to poor neurological outcomes in survivors. Older individuals are significantly more likely to suffer a cardiac arrest and have a worse long-term cognitive prognosis, yet the molecular mechanisms underlying differences between the ability of the brain in young and advanced age individuals to withstand a global cerebral ischemic insult are unknown. The proposed studies will analyze the role of aging-associated inflammation in the brain's response to global cerebral ischemia and may ultimately lead to new therapies for the treatment of cognitive dysfunction after a cardiac arrest.

PI_NAMEs: BASAK, JACOB  (contact)

PROJECT_TERMS: Acute;Address;Adult;Age;age difference;age related;age related neurodegeneration;aged;Aging;aging brain;aging process;aging related;Animal Model;animal old age;Animals;Attenuated;Award;Basic Science;Behavior assessment;Behavioral;Biochemical;Biology of Aging;Brain;Brain Diseases;brain dysfunction;Brain Injuries;Brain Ischemia;Cardiopulmonary Resuscitation;Caring;CASP1 gene;Cell Death;cell injury;Cells;Cerebral Ischemia;cerebral ischemic injury;Clinical Management;Cognition;Cognitive;Cognitive deficits;Complement;Complex;Critical Care;Data;Doctor of Philosophy;Elderly;Electrophysiology (science);Encephalitis;Environment;Evaluation;Exhibits;experience;Experimental Designs;Functional disorder;Funding;glial activation;Goals;Heart Arrest;Hippocampus;Histologic;Impaired cognition;Impairment;improved;Incidence;Individual;Induced Neurons;Inflammaging;Inflammasome;Inflammation;Injury;Intensive Care Units;Ischemia;Ischemic Brain Injury;K-Series Research Career Programs;Knowledge;Link;mature animal;Measurement;Measures;Mediating;Mediator;Memory;Memory impairment;Mentors;Mentorship;Microglia;Modeling;Molecular;mouse model;Multiprotein Complexes;Mus;Nerve Degeneration;Nervous System Physiology;neuroinflammation;Neurologic;Neurological outcome;neuron loss;Neuronal Injury;novel;novel therapeutic intervention;novel therapeutics;old mice;Older Population;Pathway interactions;Patients;pharmacologic;Physicians;Play;Procedures;Process;Prognosis;Proteins;Research;Research Personnel;Research Training;response;response to brain injury;Role;Scientist;skills;Structure;Survivors;Synapses;synaptic function;Synaptic plasticity;Testing;Therapeutic Agents;Time;Translational Research;Translations;United States;young adult

PROJECT_TITLE: Aging-associated changes in the brain's response after a cardiac arrest


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative Hearing loss in midlife (ages 45-65) is posited as a target for preventing Alzheimer's disease and Alzheimer's disease related dementias, but it is unknown whether hearing loss is associated with cognition or brain health in midlife. This study will link newly collected objective hearing tests with cognitive and brain MRI assessments in a well-characterized and diverse cohort of middle-aged adults. This study's findings will provide critical insights into midlife haring loss and brain health, which may offer an avenue for reducing late-life dementia risk.

PI_NAMEs: BRENOWITZ, WILLA DOMINO (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Adult;Age;age related neurodegeneration;aging brain;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Auditory area;biracial;Black American;Black race;brain health;brain magnetic resonance imaging;Brain region;brain volume;caucasian American;Cognition;Cognitive;cognitive testing;cohort;Coronary Artery Risk Development in Young Adults Study;cost efficient;critical period;Dementia;dementia burden;dementia risk;Development;Education;emerging adult;entorhinal cortex;Epidemiology;Face;Frequencies;Future;Genotype;Goals;Hares;health inequalities;Hearing;Hearing Aids;hearing impairment;Hearing Tests;high risk;Hippocampus;human old age (65+);Impaired cognition;Income;Inequity;insight;Intervention;Investigation;Knowledge;late life;Link;Longitudinal Studies;Low income;Measures;men;Methods;middle age;Modeling;modifiable risk;multidisciplinary;Neuropsychological Tests;Not Hispanic or Latino;older adult;Outcome;Participant;Presbycusis;prevent;Prevention;Race;racial difference;racial diversity;Risk Factors;risk stratification;Role;screening;Sensory impairment;sex;social health determinants;Social isolation;Speech;Standardization;Subgroup;Testing;Time;Underrepresented Populations;Vascular Diseases;White Matter Hyperintensity;Woman

PROJECT_TITLE: Evaluating the associations of hearing loss with cognitive and brain health outcomes in midlife

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: Los Angeles

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Deep brain stimulation (DBS) is an effective adjunct for treating the cardinal motor features of Parkinson's disease (PD), but is less effective at treating cognitive symptoms. Typical DBS stimulation parameters utilize high frequency gamma stimulation (100-180 Hz); however, there is growing evidence that low frequency theta (4-8 Hz) oscillations are important in various aspects of cognition, including verbal fluency, working memory, response inhibition and sensorimotor conflict. We hypothesize that theta-burst stimulation of the subthalamic nucleus will confer a cognitive benefit over time while maintaining the motor benefit of high frequency stimulation.

PI_NAMEs: LEE, DARRIN JASON (contact)

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Acute;Affect;Alzheimer's Disease;arm;Attention;Bradykinesia;Brain;Caring;Chronic;Clinical;Cognition;Cognitive;cognitive benefits;Cognitive deficits;cognitive function;cognitive impairment in Parkinson's;cognitive task;Collaborations;Conflict (Psychology);Crossover Design;Data;Data Analyses;Deep Brain Stimulation;Dementia;Disease Progression;Double-Blind Method;effective therapy;Episodic memory;Executive Dysfunction;executive function;Foundations;Frequencies;Functional Magnetic Resonance Imaging;functional MRI scan;Globus Pallidus;Goals;Hippocampus;Human;Impaired cognition;Impairment;Implant;implantation;impression;improved;Individual;Learning;Lewy Body Dementia;Light;Measures;Memory;Motor;motor symptom;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Movement Disorders;Muscle Rigidity;Nerve Degeneration;Neurobehavioral Manifestations;non-motor symptom;novel;Operative Surgical Procedures;Outcome;Parietal;Parkinson Disease;Parkinson's Dementia;Patients;pharmacologic;Phase;Phase II Clinical Trials;Phase III Clinical Trials;Pilot Projects;Prevalence;primary outcome;processing speed;Quality of life;Randomized;Research;response;Rest;Rest Tremor;Safety;selective attention;Severities;Short-Term Memory;standard of care;STN stimulation;Structure of subthalamic nucleus;symptomatic improvement;Symptoms;Task Performances;Testing;Theta Rhythm;Time;Training;verbal;Visuospatial;Work

PROJECT_TITLE: Theta burst subthalamic nucleus deep brain stimulation for cognitive and motor improvements in Parkinson's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-G (65)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Prevention;Women's Health Research

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative More than 40% of pregnancies in the United States are undesired and non-use or inconsistent use of contraceptives is the leading cause. People must balance competing goals when striving to prevent pregnancy, but the literature on contraceptive use lacks a robust conceptual framework, measures, and data to analyze risk perceptions and tolerance as psychological mechanisms undergirding contraceptive decision-making amid conflicting goals particularly with data from both partners. The proposed research addresses barriers to scientific progress by (1) identifying the association between risk tolerance and contraceptive use among men and women via pilot data collected on pretested measures of risk tolerance adapted from psychology and (2) quantifying the relationship between risk perceptions and contraceptive use among couples.

PI_NAMEs: LITTLEJOHN, KRYSTALE E. (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Advisory Committees;Affect;analytical method;Applications Grants;Attitude;avoid pregnancy;Award;Barbering;Behavior;behavior influence;cognitive interview;Contraception Behavior;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Couples;Data;Data Analyses;Decision Making;Demography;design;Development;Equilibrium;Exclusion;experience;Fertility;Funding;Future;Gender;Goals;Grant;health goals;Health Psychology;high risk;Human;improved;Indiana;Individual;innovation;insight;interdisciplinary approach;Interdisciplinary Study;Knowledge;Learning;Link;Literature;Lived experience;longitudinal analysis;Longitudinal Studies;male;man;Measures;member;men;Men's Role;Mentors;Methods;Modeling;multidisciplinary;multilevel analysis;National Institute of Child Health and Human Development;Neurosciences;novel;Oregon;Pathway interactions;Personal Satisfaction;Persons;Play;Population Dynamics;population health;preference;Pregnancy;prevent;Process;psychologic;Psychology;Public Health;public health priorities;Questionnaires;Research;Research Activity;Research Personnel;Risk;risk perception;Role;Services;sex;skills;skills training;sociologist;Sociology;standardize measure;Surveys;Testing;Texas;theories;Time;tool;Training;Training Activity;United States;Universities;Woman;Women's Health;Work;Writing

PROJECT_TITLE: Risk Perception and Tolerance in Contraceptive Use

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-C (03)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Dementia;Microbiome;Neurodegenerative;Neurosciences;Obesity;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Upwardly mobile youth who “strive” to rise above poverty typically have better cognitive outcomes - which is protective against Alzheimer's Disease (AD) - but this striving may be stressful, and can induce health problems such as altered brain-gut axis signaling and systemic inflammation. Women are at greater risk for striving-related stress, stress-related health problems, and critically, when they possess other risk factors such as apolipoprotein-ε4 (ApoE-ε4) gene status, they are more likely to develop AD. Using a cohort of young adults who were part of a natural educational experiment, we will test the hypothesis that due to sex-specific vulnerabilities (such as stress) females, but not males, with greater mobility opportunity will exhibit more physical health risks (namely obesity and inflammation as well as altered gut microbiome profiles) in early adulthood, which will in turn be negatively associated with cognitive outcomes and brain structure/function that could put them at risk for AD.

PI_NAMEs: CALLAGHAN, BRIDGET L (contact);SILVERS, JENNIFER ASHLEY

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Admission activity;Adolescence;Adolescent;Adult;Age;Alzheimer's Disease;Alzheimer's disease risk;Apolipoproteins;arm;Blood;Blood - brain barrier anatomy;Brain;brain health;Childhood;Cognition;Cognitive;cognitive ability;cognitive function;cohort;Data;Dementia;Development;Education;emerging adult;Exhibits;expectation;Experimental Designs;experimental study;Family;Feces;Female;follow-up;Follow-Up Studies;Functional disorder;Gender;Gender Role;Genes;genetic risk factor;gut microbiome;gut-brain axis;Health;Health Care Costs;high school;indexing;Individual;Inequity;Inflammation;Inflammatory;inflammatory marker;Intestinal permeability;late life;Life;Link;Magnetic Resonance Imaging;male;Measures;Mediating;Mediator;metagenome;microbiome;Natural experiment;Neighborhoods;Nerve Degeneration;nerve injury;neurocognitive test;neuroinflammation;Obesity;Observational Study;older adult;Outcome;Pathway interactions;Patient Self-Report;Peripheral;physical conditioning;Poverty;Public Health;Randomized;recruit;Reporting;resilience;retention rate;Risk;Risk Factors;Risk Reduction;Schools;sex;Sex Differences;Signal Transduction;social;Standardization;Stress;Structure;Students;systemic inflammatory response;Testing;Woman;young adult;Youth

PROJECT_TITLE: Testing sex as a moderator of health impacts of upward mobility on indicators for AD risk in young adulthood

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Rehabilitation;Serious Mental Illness

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE. Sensorimotor disturbances have long been identified in psychotic disorders and may serve as objectively measurable readouts of fundamental process disturbances that drive clinical phenomenology. Determining which metrics of a motor learning task capture this dysfunction and fluctuate over time with symptoms is critical in linking aberrant behavior processes to the disruption of distinct neural circuits and resulting clinical symptoms. Enriching our models of brain-behavior-symptom relationships can then be leveraged to identify and develop targeted interventions for psychosis onset and maintenance.

PI_NAMEs: MOUSSA-TOOKS, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Affect;Behavior;Behavioral;Brain;brain behavior;brain volume;career;Cerebellum;Clinical;Clinical assessments;Clinical Psychology;clinical translation;clinically relevant;Cognitive;comparison group;Complex;Computer Models;computerized;Data;Data Analyses;Delusions;Diagnosis;Discipline;Disease;Doctor of Philosophy;Ensure;Exhibits;expectation;experience;follow-up;Foundations;Functional disorder;Future;Goals;Grant;Hallucinations;Heterogeneity;Hospitalization;Indiana;Individual;Intervention;Intervention Studies;K-Series Research Career Programs;Knowledge;Learning;learning strategy;Link;Maintenance;Maps;Measurable;Measurement;Measures;Mediating;Mentors;Mentorship;Methods;Modeling;Motor;motor learning;neural circuit;neuroimaging;Neurosciences;Noise;novel;Outcome;Participant;patient oriented;patient subsets;Patients;phenomenological models;primary outcome;Process;professor;Psychiatry;psychologic;Psychomotor Performance;Psychoses;Psychotic Disorders;psychotic symptoms;Recovery;recruit;Relapse;Research;Role;Science;Scientist;secondary outcome;Sensorimotor functions;sensorimotor system;Sensory;Severities;skills;Structure;Subgroup;Symptoms;System;tenure track;therapy development;Time;Training;Translational Research;Universities;Update;Work;Workplace

PROJECT_TITLE: Longitudinal Assessment of Distinct Motor Learning Processes to Inform Mechanistic Models of Sensorimotor Function in Psychosis

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Physical Activity;Racial and Ethnic Minority Health Research

PHR: Project Narrative Black adults are disproportionately affected by chronic kidney disease (CKD) and have some of the worst health outcomes among those with CKD. Sedentary behavior is associated with poor health outcomes and is an extremely common behavior in those with CKD. This project will adapt and test an intervention to reduce sedentary behavior for Black adults with CKD, which will inform the development of a future large-scale trial to reduce sedentary and improve health outcomes in this at-risk population.

PI_NAMEs: HANNAN, MARY  (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Address;Adult;Adverse effects;Affect;attentional control;Award;Behavior;Behavior Therapy;Behavioral;Black Populations;Black race;cardiometabolism;career development;Chronic Kidney Failure;Clinical;Clinical Trials Design;Competence;Data;depressive symptoms;design;Development;Devices;Disease Progression;Disparity;effective intervention;efficacy trial;evidence base;Evidence based intervention;Exercise;exercise intervention;experience;Foundations;Future;Goals;group intervention;Health;health disparity;health equity;health equity promotion;Health equity research;health inequalities;health outcome disparity;health related quality of life;healthy lifestyle;high risk;Hour;improved;improved outcome;Individual;innovation;Intervention;intervention participants;Investigation;K-Series Research Career Programs;Knowledge;Life Style;Lived experience;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Minority Groups;Mission;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Nursing Research;Nephrology;Nurse Practitioners;Nurses;Nursing Research;Outcome;outcome disparities;patient oriented;Patient Outcomes Assessments;Patient Self-Report;Patients;Personal Satisfaction;pilot test;poor health outcome;Population;Populations at Risk;primary outcome;programs;Quality of life;Randomized;Randomized, Controlled Trials;Research;Risk;Sampling;Scientist;secondary outcome;sedentary;sedentary lifestyle;social;social cognitive theory;success;Testing;theories;Time;Training;trend;Underrepresented Minority;Walking;wearable device;Work

PROJECT_TITLE: An intervention to reduce sedentary behavior for Black adults with chronic kidney disease: RESET-CKD

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (89)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Neurosciences;Osteoarthritis;Pain Research;Patient Safety;Physical Activity

PHR: Project Narrative This renewed K24 Midcareer Investigator Award in Patient-Oriented Research of Integrative Medicine will expand the Candidate’s research and mentoring program in Translational Science of Complementary and Integrative Health. The main goals of this program will be: Goal 1: Conduct rigorous research into developing new interventions; testing the efficacy and effectiveness and implementation of the mind-body therapies; Goal 2: Advance expertise in implementation science; Goal 3: Develop an expertise in rTMS neuromodulation added to the mind-body interventions via direct training and research; Goal 4: Mentor future CIH researchers at multiple levels of training (medical students, graduate and post-graduate trainees in psychology, neuroscience, medicine and psychiatry) in Translational Science of the CIH. The proposed research, mentoring, and training programs are based on the currently funded studies, and a new proposed pilot project.

PI_NAMEs: LAVRETSKY, HELEN  (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: Adherence;Adult;Adverse event;Affect;aged;American;Analgesics;Anguish;Appointment;arthritic pain;Arthritis;Behavioral;bench-to-bedside translation;Boston;Brain;burden of illness;California;care costs;Chronic Disease;Clinic;clinical diagnosis;Clinical Practice Guideline;clinical training;Cognition Disorders;collaboratory;college;Communities;comorbidity;comparative;Complementary Health;Consultations;Degenerative polyarthritis;depressive symptoms;digital;Dimensions;disability;Dropout;Educational Curriculum;Educational Status;Effectiveness;efficacy testing;Electronic Health Record;Enrollment;Exercise;Exhibits;experience;Faculty;Feasibility Studies;feasibility testing;feasibility trial;Florida;Foundations;Funding;Funding Agency;Future;Geographic Locations;Goals;Grant;Guidelines;health care service utilization;Health education;Health Sciences;Healthcare Systems;implementation research;implementation science;implementation trial;improved;Individual;Injections;Integrative Medicine;International;Intervention;Interview;Knee;Knee Osteoarthritis;knee pain;Left;Link;Massachusetts;Medical Care Costs;Medical center;Medical Students;Medicine;member;Mental Depression;Mental Health;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;mild cognitive impairment;Mind-Body Intervention;mind/body;Mood Disorders;Motor Cortex;Musculoskeletal Pain;National Center for Complementary and Integrative Health;National Institute of Mental Health;neuromechanism;neuroregulation;Neurosciences;Nonpharmacologic Therapy;novel;Ohio;older adult;Online Systems;Operative Surgical Procedures;osteoarthritis pain;Outcome;Pain;Pain Disorder;Pain interference;pain relief;pain symptom;Parents;patient oriented;Patients;Persons;Pharmacological Treatment;Pharmacotherapy;Phase;Philosophy;physical conditioning;Physical Function;physical impairment;Pilot Projects;pragmatic trial;Prefrontal Cortex;primary outcome;Procedures;Productivity;programs;Protocols documentation;Psyche structure;Psychiatry;Psychology;psychosocial;Quality of life;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;remote delivery;repetitive transcranial magnetic stimulation;Replacement Arthroplasty;Research;Research Personnel;Research Priority;Research Proposals;retention rate;Rheumatology;routine care;Safety;safety assessment;satisfaction;secondary outcome;Serious Adverse Event;Severities;Site;social;Structure;Surveys;Symptoms;Tai Ji;Testing;Time;Training;training opportunity;Training Programs;Translational Research;Treatment Protocols;treatment strategy;trial enrollment;Underrepresented Minority;United States National Institutes of Health;virtual;whole health;Woman

PROJECT_TITLE: Mentoring and Research in Translational Science of Integrative Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (05)]