NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Cardiovascular;Complementary and Integrative Health;Genetics;HIV/AIDS;Heart Disease;Human Genome;Infectious Diseases;Microbiome;Nutrition;Precision Medicine;Prevention;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PUBLIC HEALTH RELEVANCE This research study will examine how alcohol associated gut dysbiosis may lead to harmful downstream health effects, i.e., inflammation, CVD, and excess mortality, among PWH who are hazardous drinkers. By conducting whole genome sequencing on the gut microbiota within three rich existing cohorts, the study will be able to address this important public health question in a cost-effective and innovative manner. Results will inform precision medicine approaches targeting gut dysbiosis as an intervention for CVD, inflammation, etc., in PWH.

PI_NAMEs: MONNIG, MOLLIE A (contact)

PROJECT_TERMS: Address;Alcohol consumption;alcohol effect;alcohol research;alcohol use disorder;Alcohols;Amines;Antibiotic Therapy;Back;Bacteria;Bacterial Genes;biobehavior;Biological Markers;Butyrates;cancer therapy;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;career;Cessation of life;Characteristics;Circulation;cohort;Cohort Studies;cost effective;Data;data harmonization;demographics;design;Diet;Disease;Disease Marker;dysbiosis;Echocardiography;Ensure;Enterocytes;Ethanol;Excess Mortality;Functional disorder;Funding;genome sequencing;gut bacteria;gut dysbiosis;gut microbiome;gut microbiota;hazardous drinking;Health;HIV;HIV Infections;indexing;Inflammation;innovation;Interleukin-6;Intervention;Left Ventricular Dysfunction;Link;lipopolysaccharide-binding protein;Lipopolysaccharides;Measures;Methods;microbial;microbiome;microbiota profiles;Modeling;modifiable risk;Morphologic artifacts;mortality;mortality risk;Myocardial dysfunction;National Institute on Alcohol Abuse and Alcoholism;novel;Observational Study;Oxides;Participant;Pathogenicity;personalized intervention;Persons;Plasma;prebiotics;precision medicine;Probiotics;Process;Public Health;public health relevance;Request for Proposals;Research Personnel;research study;response;Risk;Sampling;Serum;Specimen;stool sample;systemic inflammatory response;Technology;Testing;timeline;United States National Institutes of Health;Vascular Diseases;vascular inflammation;whole genome

PROJECT_TITLE: Alcohol assoCiated gut Dysbiosis and CVD in HIV (the AC/DC HIV study)

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: CINCINNATI

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PI_NAMEs: WINHUSEN, T JOHN (contact)

PROGRAM_OFFICER_NAME: DOBBINS, RONALD


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PI_NAMEs: PEEBLES, RAY STOKES (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Age;airway epithelium;Asthma;Birth;Child;Childhood;cohort;Development;Enrollment;Environment;Epithelial Cells;follow-up;Funding;Goals;Grant;Human;Hypersensitivity;Immune response;In Vitro;Infant;infant morbidity;innovation;Mediating;microbial;microbial host;mouse model;Outcome;Pathway interactions;Peripheral Blood Mononuclear Cell;Respiration;respiratory morbidity;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;response;T memory cell;Testing;Time;Viral;Wheezing

PROJECT_TITLE: Viral and Host Determinants of Infant and Childhood Allergy and Asthma


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects;Stroke;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Contact PD/PI: Floyd, Thomas NARRATIVE  There is growing awareness that survival and neurologic outcomes in patients experiencing intracranial hypertension after traumatic brain injury, severe stroke, or cerebral hemorrhage may be improved by strategies that focus on improving cerebral oxygenation and oxygen utilization. Currently available devices for monitoring cerebral oxygenation are extremely limited in their accuracy and have yet to demonstrate clinical efficacy. We are developing a minimally invasive brain device, FLOXBR, that measures blood flow and oxygenation and which may offer significant improvements over current technology in accuracy and clinical efficacy. Project Narrative Page 8

PI_NAMEs: FLOYD, THOMAS FREDERICK (contact)

PROGRAM_OFFICER_NAME: WU, GUANGYING

PROJECT_TERMS: Acute;Awareness;Blood flow;Brain;Brain Injuries;brain tissue;Breakthrough device;Cerebral hemisphere hemorrhage;cerebral oxygenation;Cerebrovascular Circulation;Cerebrum;clinical efficacy;clinical translation;Computer software;cranium;Data;design;Development;Device Designs;Device or Instrument Development;Device Safety;Devices;Diagnosis;Diffuse;Dura Mater;Edema;Evaluation;experience;Family suidae;feasibility testing;first-in-human;flexibility;gray matter;Human;improved;improved outcome;Intracranial Hypertension;Ischemia;Ischemic Stroke;Location;Magnetic Resonance Imaging;manufacture;Measurement;Measures;Metabolic;minimally invasive;Modeling;Modification;Monitor;monitoring device;Neurological outcome;Optics;Outcome;Oxygen;Oxygen saturation measurement;Patients;Performance;Population;pre-clinical;preclinical study;prototype;regional difference;Resolution;Safety;safety assessment;safety testing;Secondary to;Sensitivity and Specificity;Skin;Spectrum Analysis;Spinal Cord Ischemia;Stroke;Surface;Surveys;survival outcome;System;Technology;Testing;tissue oxygenation;Tissues;Translating;Trauma;Traumatic Brain Injury;Trephine hole;Validation;white matter

PROJECT_TITLE: Minimally Invasive Cerebral Blood Flow and Oxygenation Monitoring for Intracranial Hypertension

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PI_NAMEs: YAN, JUN  (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Acceleration;Adoptive Cell Transfers;Advisory Committees;Applications Grants;Area;Award;Bacterial Infections;Basic Science;Bioinformatics;Biometry;Cancer Biology;Cancer Center;cancer immunotherapeutics;cancer immunotherapy;Cancer Patient;career;Centers of Research Excellence;Clinical;Clinical Research;Collaborations;Coupled;Credentialing;Decision Making;diversity and inclusion;Education;Ensure;Evaluation;experience;Feasibility Studies;Feedback;Feeling hopeless;Funding;Goals;Grant;Human;Human Resources;Immune checkpoint inhibitor;Immune mediated destruction;Immune response;Immune system;Immunology;Immunotherapeutic agent;improved;Individual;innovation;Interdisciplinary Study;interest;International;Leadership;Malignant Neoplasms;meetings;member;Mentors;Mentorship;Molecular;Molecular Profiling;multidisciplinary;neoplastic cell;next generation;Nobel Prize;novel;Oncolytic viruses;operation;Participant;Patients;Physicians;Pilot Projects;Prediction of Response to Therapy;Procedures;Productivity;programs;Qualifying;Research;Research Personnel;Resistance;response;Role;Scientist;senior faculty;Specimen;Strategic Planning;Study Section;success;Testing;Training Programs;Translational Research;translational study;Treatment outcome;tumor;Tumor Escape;tumor immunology;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: NR

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Pain Research;Palliative Care;Rural Health;Social Determinants of Health

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative The aim of this mixed methods randomized controlled trial is to test the integrated nurse-led intervention bundle for family home care management of end-stage heart failure and palliative care in rural Appalachia. This intervention bundle is designed to address rural disparities in access to health care, with the help of the faith- based nurses and local volunteer visiting neighbors. Focus group research is used to determine plans for sustaining the bundle implementation, maintaining rural volunteers, and coordinating administrative aspects of the program.

PI_NAMEs: PIAMJARIYAKUL, UBOLRAT  (contact)

PROGRAM_OFFICER_NAME: AKUBU-ODERO, MAUREEN KALAMBU

PROJECT_TERMS: access disparities;Address;advanced directive;Aging;American;Anxiety;Appalachian Region;care giving burden;caregiving;Cessation of life;Collaborations;comparison control;comparison group;Control Groups;cost;Death Rate;design;Deterioration;Discipline of Nursing;Disease;Disparity;end of life;Faith;Family;Family Caregiver;Focus Groups;follow-up;Fright;group intervention;Health;health care availability;health disparity;health equity;health inequalities;Health Services Accessibility;Healthcare;Heart failure;Home;hospital readmission;Housing;human old age (65+);implementation cost;Improve Access;improved;Intervention;intervention cost;literacy;Managed Care;Measures;Mental Depression;Methods;Morbidity - disease rate;mortality;Nurses;older adult;Outcome;Pain;Palliative Care;Participant;participant enrollment;Patient Care;patient home care;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;Policies;preference;programs;Quality of life;Questionnaires;randomized, clinical trials;Randomized, Controlled Trials;Readiness;recruit;Religion;Reporting;Research;Research Support;Resources;Rural;Rural Appalachia;rural area;rural disparities;Rural health equity;rural underrepresented;skills;social health determinants;Social support;Telephone;Testing;theories;Travel;Visit;volunteer;West Virginia;World Health Organization

PROJECT_TITLE: Sustaining Home Palliative Care for Patients with Heart Failure (HF) and Their Family Caregivers in Rural Appalachia: A Mixed Methods Randomized Clinical Trial (RCT)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-M (44)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PI_NAMEs: UHL, GEORGE RICHARD (contact)

PROGRAM_OFFICER_NAME: WHITE, DAVID A

PROJECT_TERMS: Abstinence;Admission activity;American;amphetamine use;Amphetamines;aryldialkylphosphatase;Attention deficit hyperactivity disorder;Canis familiaris;carcinogenicity;Chemistry;Clinical;Cocaine;cocaine use;Cocaine use disorder;conditioned place preference;Dose;Dose Limiting;Enzymes;experience;FDA approved;first-in-human;genotoxicity;Goals;Hematology;Hepatic;Histopathology;Human;Intake;Kidney;Legal patent;Lesion;meetings;methamphetamine use;Microsomes;Mus;Narcolepsy;National Institute of Drug Abuse;new therapeutic target;novel;Oral;Pattern;Pharmaceutical Preparations;phase 1 study;phosphatase inhibitor;Phosphoric Monoester Hydrolases;Plasma;Protein Tyrosine Phosphatase;PTPN1 gene;Rattus;receptor;Recombinants;Reporting;Rewards;Rodent;Role;Self Administration;Series;Site;Stimulant;stimulant use disorder;Toxic effect;treatment program;Tubular formation;Weight;Work;Writing

PROJECT_TITLE: PTPRD Phosphatase inhibitors for stimulant use disorders


ORG_CITY: BOSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Patients with rare and undiagnosed conditions often face significant challenges in receiving proper diagnosis and care and accessing research opportunities, resulting in poor outcomes and straining healthcare resources. Through this project, we aim to leverage implementation science frameworks to extend the reach of the Undiagnosed Diseases Network (UDN), improve access for underserved communities, develop technical solutions tailored to the needs of the undiagnosed and rare disease community, and ensure ongoing research and care continuity for participants awaiting diagnosis.

PI_NAMEs: BELLEN, HUGO J;KOHANE, ISAAC S. (contact);PAK, STEPHEN C;POSTLETHWAIT, JOHN H.;QUARELLS, RAKALE COLLINS;SCHEDL, TIM ;SOLNICAKREZEL, LILIANNA ;WESTERFIELD, MONTE

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Address;Affect;Biomedical Research;Caring;clinical practice;clinical research site;cohort;Collaborations;Collection;Communities;community engaged approach;community engagement;community partners;Continuity of Patient Care;coping;Data;Data Analyses;Development;Diagnosis;Diagnostic;Disease;DNA Sequencing Facility;empowerment;Ensure;Evaluation;evidence base;experience;Exploration, Preparation, Implementation, and Sustainment;Focus Groups;Foundations;Funding;genome sequencing;Health;Healthcare;implementation evaluation;implementation framework;implementation science;implementation strategy;Improve Access;improved;improved outcome;Individual;innovation;insight;Intervention;Investigation;Learning;Medical;Medical Records;meetings;member;Methods;model organism;multidisciplinary;network models;Outcome;Participant;Pathogenicity;patient engagement;patient navigator;Patient-Focused Outcomes;Patients;Persons;Provider;Qualitative Methods;rare condition;Rare Diseases;Research;Research Personnel;research study;research to practice;Resources;Science;screening;skills;success;Symptoms;Technology;tool;Training;transcriptome sequencing;Translating;underserved community;Underserved Population;United States;United States National Institutes of Health;Variant;webinar

PROJECT_TITLE: Diagnosing the Unknown for Care and Advancing Science (DUCAS)


NIH_SPENDING_CATS: Genetics

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative: DNA replication restart is an important process to study from a human health perspective because knowing more about how DNA is properly maintained will help to identify targets to kill selectively the deleterious, malignant or disease-causing cells that may plague our bodies (cancer and pathogenic organisms). Conversely, this knowledge may also help to augment basic health and longevity of our bodies by the design of better antibiotics. This may be translated into a longer, healthier life for individuals.

PI_NAMEs: KECK, JAMES L (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Antibiotics;Back;Bacteria;Bacterial DNA;Binding;Biochemical;Biological;Cells;Complex;Coupled;crosslink;Cryoelectron Microscopy;Data;design;Disease;DNA;DNA biosynthesis;DNA Repair;DNA replication fork;DNA Structure;Ensure;Escherichia coli;experimental study;Funding;Genetic;genetic approach;Genetic study;Genomics;Goals;Health;helicase;Human;In Vitro;Individual;insight;Knowledge;Life;Link;Longevity;Malignant - descriptor;Malignant Neoplasms;Maps;Mediating;Modeling;Molecular;Organism;Pathogenicity;Pathway interactions;Plague;premature;prevent;Process;protein complex;Proteins;Reaction;recruit;Regulation;Replication Initiation;Role;Site;Structure;System;Translating;Visualization

PROJECT_TITLE: Structure and Function of the Bacterial Primosome

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE - PARENT GRANT (7/1/18 to 5/31/24) People aged 90 and older (the oldest-old) are the fastest growing segment of the population and have the highest rates of dementia. Many oldest old individuals, however, maintain superior cognitive performance (cognitive resilience) often despite the presence of Alzheimer's disease (AD) and other neuropathologic changes. With clinical, imaging, and pathological investigations, our goal is to identify lifestyle and other factors that contribute to resilience in this understudied and unique segment of the population.

PI_NAMEs: CORRADA, MARIA ;KAWAS, CLAUDIA H. (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Age;aged;Aged, 80 and over;Aging;Alzheimer's Disease;Biological Markers;Centenarian;Clinical;Cognitive;cognitive ability;cognitive performance;cohort;Cohort Studies;comorbidity;Databases;Dementia;dementia risk;disability;Disease;eligible participant;Enrollment;follow-up;frailty;Genetic;Goals;Health;Image;imaging biomarker;imaging study;Impaired cognition;Incidence;Individual;innovation;Intervention;Investigation;Leisures;Life Style;Magnetic Resonance Imaging;Maintenance;modifiable lifestyle factors;mortality;multidisciplinary;neuroimaging;neuropathology;Older Population;Outcome;parent grant;Participant;Pathologic;Pathology;Persons;Population;population based;Positioning Attribute;Positron-Emission Tomography;prospective;Public Health;recruit;resilience;Role;Sampling;Survivors

PROJECT_TITLE: Clinical, Imaging, and Pathological Studies in the Oldest Old: The 90+ Study - Revision


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Signaling between cells encodes spatiotemporal information crucial both for development and homeostasis, and when dysregulated, results in developmental syndromes or diseases throughout the lifespan. Vertebral segmentation is jointly controlled by the segmentation clock and FGF/ERK signaling gradient. Understanding how the clock oscillations and signaling gradient are integrated and how cells decode this information are needed to decipher the etiology of vertebral malformations and build precisely patterned organoids.

PI_NAMEs: OZBUDAK, ERTUGRUL M (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3-Dimensional;Actins;Address;Anterior;BHLH Protein;Binding;cancer type;Cell Nucleus;Cell Polarity;Cells;Characteristics;Chick;Clock protein;Complex;Computer Models;Congenital Abnormality;Cytoskeleton;Data;Data Analyses;Defect;Development;Diffusion;Disease;Dynein ATPase;Embryo;Embryonic Development;Ensure;Etiology;experimental study;Family;FGF17 gene;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Fishes;Future;Gene Family;Generations;genetic regulatory protein;Genetic Transcription;heparin proteoglycan;Homeostasis;Image;inhibitor;Investigation;Length;life span;Ligands;loss of function;malformation;Malignant Neoplasms;mathematical model;Measures;Mediating;Mesoderm;Messenger RNA;Microtubule-Organizing Center;Microtubules;Mission;Modeling;mosaic loss;Mus;Myosin ATPase;novel;Nuclear;Organ;Organoids;Pattern;Pattern Formation;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Inhibition;Positioning Attribute;Process;Proteins;real-time images;Reporter;Role;Rotation;Segmentation Clock Pathway;Signal Transduction;single molecule;Site;Somites;Source;spatiotemporal;spine bone structure;Syndrome;Testing;Time;Tissues;Transcription Repressor;United States National Institutes of Health;Update;Visualization;Work;Zebrafish

PROJECT_TITLE: Integration of spatiotemporal signaling for pattern formation and scaling

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE Protein synthesis is a major pathway targeted by antibiotics, and the rise of multi-drug resistant bacteria calls for further understanding of the translational machinery to improve current antimicrobial treatment. Escherichia coli and Salmonella enterica cause over a million illnesses and tens of thousands of hospitalizations annually in the United States alone. Our work will provide insights into adaptation of such bacterial pathogens during stress conditions and facilitate development of novel antimicrobial strategies.

PI_NAMEs: LING, JIQIANG  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Affect;Amino Acids;Antibiotics;antimicrobial;Bacteria;Behavior;Cells;Cues;Defect;Development;environmental change;Escherichia coli;fitness;Genetic;genetic information;Growth;Hospitalization;Impairment;improved;Individual;insight;interest;Laboratories;Mammals;Messenger RNA;Motility;Multiple Bacterial Drug Resistance;Nerve Degeneration;new technology;novel;pathogenic bacteria;Pathway interactions;Physiological;Population;Process;Protein Biosynthesis;Proteins;Quality Control;Regulation;Reporter;Research;response;Role;Salmonella;Salmonella enterica;Stress;System;Terminator Codon;translational genetics;United States;virulence gene;Work

PROJECT_TITLE: Regulation and Physiological Roles of Translational Fidelity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The proposed K01 career development and research activities merge intervention science with phylogenetic analysis to address the co-occurring epidemics of HIV, hepatitis C, and opioid use among people who inject drugs along the Texas-Mexico Border. Research activities are guided by the Multiphase Optimization Strategy (MOST) Preparation Phase including formative intervention development activities and a feasibility and acceptability trail using a factorial experiment design. Our trial will lay the foundation for a full-scale MOST trial in the future that tests four intervention components that aim to reduce drug use, promote HIV prevention, and increase HCV cure, with phylogenetic analysis conducted in parallel to determine sub-optimal HCV treatment outcomes and transmission networks. Proposed training and research activities will provide a platform to launch an early-stage investigator’s long-term career in intervention science and novel biomarker research.

PI_NAMEs: LUDWIG-BARRON, NATASHA  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Affect;AIDS prevention;Behavioral;biobehavior;Biological Markers;care outcomes;career;career development;Caring;Cessation of life;Clinical;Cluster Analysis;Communities;community partnership;Continuity of Patient Care;Data;Data Collection;design;Drops;Drug usage;Education;Effectiveness;effectiveness trial;Epidemic;Epidemiologist;Equipment;evidence base;experience;Experimental Designs;experimental study;Feedback;Foundations;Funding;Future;genetic linkage;Genetic Markers;hands-on learning;Harm Reduction;Hepatitis C;Hepatitis C Prevalence;Hepatitis C Therapy;High Prevalence;HIV;HIV risk;HIV/HCV;Human immunodeficiency virus test;Individual;Infection;informant;Injecting drug user;Injections;Intervention;intervention delivery;Interview;Knowledge;Latino Population;learning strategy;Location;Measures;Mediator;Mentorship;Methods;Mexican Americans;Mexico;Modeling;Modernization;mortality;multi-component intervention;multiphase optimization strategy;National Institute of Drug Abuse;Needle Sharing;novel;novel marker;novel strategies;Opioid;opioid agonist therapy;opioid overdose;opioid use;Outcome;Participant;peer;peer support;Persons;Pharmaceutical Preparations;Phase;Phylogenetic Analysis;pre-exposure prophylaxis;Preparation;Prevention strategy;primary outcome;Procedures;Protocols documentation;Proxy;Public Health;Publishing;Randomized;recruit;Research;Research Activity;Research Personnel;Resistance;Resistance development;Retreatment;Risk;Risk Behaviors;Route;Sampling;scale up;Science;secondary outcome;service organization;Services;Strategic Planning;Subgroup;substance use;Syringes;Testing;Texas;therapy development;trafficking;Training;Training Activity;Training Support;transmission process;Treatment Failure;Treatment outcome;underserved community;Unsafe Sex;Viral

PROJECT_TITLE: Proyecto Vida: Developing an HIV, HCV and opioid use MOST intervention for persons who inject drugs along the Texas-Mexico Border

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Modified Public Health Relevance Section African Americans are 60% more likely to develop T2D than non-Hispanic whites, even after correction for obesity and lifestyle factors. A sequence variant rs142619613 that occurs mainly in African Americans contributes to hepatic insulin resistance, hyperglycemia and metabolic dysfunction-associated fatty liver disease (MAFLD). These findings aim to bridge the knowledge gap on T2D disparities among African Americans and introduce a novel therapeutic target for both disorders.

PI_NAMEs: SONG, GUISHENG  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Address;African American population;atypical protein kinase C;Automobile Driving;Binding;Biological;blood glucose regulation;Body Weight;C2 Domain;Carbohydrates;Chronic Disease;Clinical;Code;combat;Complex;CRISPR/Cas technology;Databases;design;Development;Diet;dietary;Disease;Disparity;Eating;Environmental Risk Factor;ethnic difference;Ethnic Origin;Fatty acid glycerol esters;fatty acid oxidation;Fatty Liver;fatty liver disease;Genes;Genetic;Genetic Transcription;Genome;Gluconeogenesis;Glucose;glucose metabolism;Glycolysis;Glycolysis Inhibition;Goals;Health system;Hepatic;Hepatocyte;High Prevalence;Homeostasis;Human;Hyperglycemia;Incidence;Individual;insight;Insulin Resistance;insulin signaling;knock-down;Knowledge;leucine-rich repeat protein;lifestyle factors;lipid biosynthesis;Lipids;Liver;Liver Fibrosis;liver inflammation;Measures;Metabolic;Metabolic Diseases;Metabolic dysfunction;Mining;Missense Mutation;Mus;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Nucleotides;Obese Mice;Obesity;Pathogenesis;Patients;PH Domain;Phenotype;Phosphorylation;Predisposing Factor;prevent;programs;Protein Dephosphorylation;protein kinase C lambda;Protein phosphatase;Proto-Oncogene Proteins c-akt;public health relevance;racial difference;Role;Scaffolding Protein;social factors;Steatohepatitis;Techniques;Testing;Therapeutic;therapeutic target;Time;Transcript;Transcription Coactivator;Variant;Weight;YY1 Transcription Factor

PROJECT_TITLE: Role of YY1 in promoting hepatic insulin resistance, hyperglycemia and NAFLD

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Patient Safety

ORG_CITY: LAKE SUCCESS

ORG_STATE: NY

PI_NAMEs: HART, RAFFAELLA  (contact)

PROJECT_TERMS: Address;adjudication;Cause of Death;Clinical Trials;cohort;Cohort Studies;Communities;Contracts;cost efficient;Cost Savings;Costs and Benefits;Data;data registry;Development;Division of Cancer Control and Population Sciences;Division of Cancer Epidemiology and Genetics;Eligibility Determination;Ensure;epidemiology study;Ethical Review;expectation;expedited review;Expenditure;follow-up;Funding;high standard;Human Subject Research;improved;Individual;Institution;Institutional Review Boards;Intake;Leadership;Link;Malignant Neoplasms;meetings;Methods;minimal risk;Minimal Risk Study;Modification;neoplasm registry;Office for Human Research Protections;Participant;Patients;Policies;Procedures;Process;Protocols documentation;Registries;Regulation;Research;Research Personnel;Resources;Risk;Site;Source;Specific qualifier value;Speed;success;System;Systems Integration;Time;United States;United States Dept. of Health and Human Services;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: CENTRALIZED INSTITUTIONAL REVIEW BOARD TO REVIEW MINIMAL RISK REGISTRY LINKAGE STUDIES "CIRB"


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SAN DIEGO

ORG_NAME: PAXVAX, INC.

PHR: The contract will support the stability of two HIV vaccine candidates currently being tested in clinical trials.

PI_NAMEs: EYLER, JESSICA  (contact)

PROJECT_TERMS: Adenovirus Vector;Biological Assay;Clinical Trials;Contracts;HIV vaccine;Mediation;programs;Protocols documentation;Services;Testing;vaccine candidate

PROJECT_TITLE: Extended Stability Program Testing of Two Adenoviral HIV Vaccine Candidates


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: Joint pain and stiffness associated with osteoarthritis and synovial fibrosis affects a large population of active duty military and veterans with an incidence higher than the general public, and the research goal of this proposal is to test a non-surgical intervention to alleviate joint stiffness and protect the joint’s cartilage surfaces. By targeting synovial cell contractility, or how much a cell pulls on its local environment, we introduce a therapy that can both mitigate fibrotic cell differentiation and restore lubricant expression in joints. Overall, this work has the potential to introduce a new treatment option for veterans experiencing joint pain and stiffness that can delay surgical intervention.

PI_NAMEs: SCANZELLO, CARLA ROSE (contact)

PROJECT_TERMS: active duty;Address;Affect;Area;Arthralgia;articular cartilage;Attenuated;Behavior;Biochemical;Biophysics;Body System;Cartilage;cell behavior;Cell Differentiation process;Cell Nucleus;Cells;cellular targeting;chondroprotection;Contracture;Cues;cytokine;Cytoskeleton;Data;Degenerative polyarthritis;Deposition;Development;disability;Disease;Drug Delivery Systems;Drug Targeting;druggable target;Elements;end stage disease;Environment;Epigenetic Process;experience;Exposure to;Extracellular Matrix;fasudil;Fibroblasts;Fibrosis;functional restoration;General Population;Goals;Homeostasis;Human;Immobilization;In Vitro;Incidence;Incubated;Injury;innovation;Intervention;joint destruction;joint function;joint injury;joint stiffness;Joints;Kidney;knee replacement arthroplasty;Knowledge;Liver;Lubricants;lubricin;Lung;Mechanics;mechanotransduction;Mediating;Mediator;Memory;microsphere delivery;Microspheres;Military Personnel;military veteran;Modeling;Movement;Myofibroblast;Operative Surgical Procedures;Organ;Oryctolagus cuniculus;Pathology;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;Phenotype;Population;Prevalence;Proteins;Regulation;Research;Role;Science;Signal Transduction;small molecule;small molecule therapeutics;Source;Surface;Synovial Cell;Synovial Fluid;Synovial Membrane;Testing;therapeutic target;Time;Tissues;transcription factor;Transcriptional Coactivator with PDZ-Binding Motif;Transforming Growth Factor beta;treatment strategy;United States;Veterans;Work

PROJECT_TITLE: Targeting Cellular Mechanosensing to Alleviate Joint Stiffness in Synovial Fibrosis

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Prevention;Vector-Borne Diseases

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative: The Epicenter for Emerging Infectious Disease Intelligence will establish research hubs in the Amazon and Congo Basin forest for emerging infectious disease research, building on our demonstrated commitment to capacity strengthening in these regions. Our proposed research will enhance surveillance for arboviruses and filoviruses in acute febrile illness cases, vectors, and vertebrate hosts that are perpetuating transmission in forest and urban systems. This work will advance an understanding of cross-species transmission dynamics for emerging viral threats, as well as optimize innovative and deployable surveillance and testing strategies to strengthen infectious disease surveillance and enable rapid response to outbreaks as part of the Emerging Infectious Disease Research Center network.

PI_NAMEs: BARKER, CHRISTOPHER M;COFFEY, LARK L;EVANS, TIERRA SMILEY;JOHNSON, CHRISTINE KREUDER (contact);MORRISON, AMY CELESTE

PROGRAM_OFFICER_NAME: WOODSON, SARA ELAINE

PROJECT_TERMS: Acute;acute infection;Animals;Arboviruses;Area;Chiroptera;Clinic;cohort;Collaborations;Communicable Diseases;Communities;Congo;Consensus;Country;Coupled;cross-species transmission;Culicidae;deep sequencing;Detection;Disease;disease model;Disease Outbreaks;Disease Surveillance;disease transmission;disorder risk;Early Diagnosis;Ecosystem;Emerging Communicable Diseases;emerging infectious disease evolution;emerging virus;Enrollment;Ensure;epidemiological model;Epidemiology;Ethics;Event;Evolution;experience;Fever;Filovirus;forest;global health;Goals;Government;Health;high risk;Human;Immunodiagnostics;improved;Infectious Disease Epidemiology;Infectious Diseases Research;Influenza;innovation;insight;Institution;integration site;Intelligence;International;Investigation;Medical Entomology;Methods;Microbiology;Modeling;Monitor;multidisciplinary;National Institute of Allergy and Infectious Disease;new pandemic;next generation;nonhuman primate;novel;outbreak concern;outbreak preparedness;outbreak response;pandemic potential;Pathogen detection;Peripheral;Persons;Peru;Pilot Projects;Predisposition;Readiness;Recording of previous events;Research;Research Activity;Research Priority;Resources;response;Rest;Reverse Transcriptase Polymerase Chain Reaction;Risk;RNA Viruses;Scientist;Seasons;Security;Serology;Site;Source;Surveillance Program;System;Techniques;Technology;Testing;Time;tool;transmission process;Uganda;urban setting;Urbanization;vector;vector-borne;Viral;viral transmission;virology;Virus;vulnerable community;Work;Zoonoses;zoonotic spillover

PROJECT_TITLE: EpiCenter for Emerging Infectious Disease Intelligence


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: DURHAM

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: The Duke Environmental Analysis Research Laboratory (DEAL) aims to support cutting-edge research to evaluate human exposure to environmental contaminants and identify new chemical threats to human health. The research and the data they provide will help researchers across the nation understand links between chemical exposures and human health outcomes.

PI_NAMEs: FERGUSON, P. LEE;STAPLETON, HEATHER M (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Administrative Coordination;air monitoring;analytical method;Aromatic Polycyclic Hydrocarbons;Biological;Chemical Exposure;chemical threat;Chemicals;Chronic Disease;Collaborations;Community Health;Consultations;Core Facility;Data;data exchange;Development;Devices;disorder risk;Dust;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Pollutants;Epidemiologist;epidemiology study;experience;Experimental Designs;exposed human population;exposure pathway;Exposure to;Flame Retardants;Funding;Future;Health;Human;improved;Individual;Infrastructure;innovation;interest;Intervention;Knowledge;Laboratories;laboratory development;Laboratory Research;Leadership;Link;Mass Spectrum Analysis;Measurement;Measures;media use;Methods;new technology;novel strategies;Office of Administrative Management;Outcome;persistent organic pollutants;Pesticides;phthalates;pollutant;Populations at Risk;Preparation;Productivity;programs;Qualifying;Quality of life;Recording of previous events;Research;Research Personnel;research study;Research Support;Resolution;Resources;Risk;risk mitigation;sample collection;Sampling;Science;Scientist;screening;Services;Silicones;Soil;Technical Expertise;Technology;Time;tool;Trace metal;Training;United States National Institutes of Health;Universities;Water;wristband

PROJECT_TITLE: Duke Environmental Analysis Laboratory

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


PI_NAMEs: STAPLETON, HEATHER M (contact)

PROJECT_TERMS: Administrative Efficiency;Annual Reports;Benchmarking;Budgets;Client;Communication;Communities;Consultations;Data;data centers;Dedications;Development;Ensure;Environmental Exposure;Environmental Impact;Epidemiologist;Evaluation;Feedback;Goals;Grant;Health;Human;improved;Laboratories;laboratory experiment;Laboratory Research;Methods;Mission;Monitor;novel strategies;Occupational activity of managing finances;operation;Personnel Management;programs;Proteomics;Recommendation;Research;research and development;Research Personnel;Research Support;Resources;Sampling;Science;Self Assessment;Services;South Carolina;Structure;synergism;Time;timeline;United States Environmental Protection Agency;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Admin Core


ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The Mount Sinai Human Health Exposure Analysis Resource (HHEAR) Laboratory Network Hub will advance public health in the United States by supporting state-of-the-art exposure science and biological response methods designed to discover the environmental causes of disease and disability in people of all ages.

PI_NAMEs: ARORA, MANISH  (contact)

PROJECT_TERMS: Acceleration;Adolescence;Adult;Affect;Age;Analytical Chemistry;Archives;Automatic Data Processing;Behavioral;Biological;Biological Assay;Biological Markers;Blood;case control;Cellular Structures;Charge;Chemical Exposure;Chemicals;Childhood;Chronic Disease;Client;clinical practice;Communication;Complex;complex data;Consultations;Creativeness;critical period;Data;data centers;Data Scientist;Data Set;design;Development;Developmental Biology;disability;Disease;disorder risk;Dose;Dryness;Ensure;Environment;environmental chemical;Environmental Epidemiology;Environmental Exposure;Environmental Health;Environmental Risk Factor;epidemiology study;Exposure to;Faculty;fetal;flexibility;Funding;gene environment interaction;Genes;Genetic;Genomics;Grant;Growth;Hair;Health;health goals;Health Priorities;Human;innovation;Institution;instrumentation;interest;Investments;Laboratories;Life;Life Cycle Stages;life span;Link;lipidomics;Liquid substance;mass spectrometer;Measures;medical schools;metabolomics;Methodology;Methods;microbiome;microbiome research;microorganism;Mission;Modeling;Molecular;Molecular Biology;molecular dynamics;multidisciplinary;Nature;Neonatal;novel;novel marker;Occupations;operation;Outcome;Pathogenicity;Pathway interactions;Persons;Phenotype;Physiological;Placenta;prenatal;Preparation;Procedures;programs;Prospective cohort;Proteomics;Protocols documentation;Public Health;Research;Research Personnel;Resources;response;Risk;sample collection;Sampling;Science;Services;Shipping;social;Specific qualifier value;Speed;Spottings;stressor;Technology;Time;Tooth structure;Toxicokinetics;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Mount Sinai HHEAR Network Untargeted Lab Hub


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD);Prevention

PROJECT_TERMS: Address;Age;Analytical Chemistry;arm;Biological;Biological Assay;Biological Markers;Biology;Blinded;Blood;Budgets;Chemical Exposure;Chemicals;Client;Collaborations;Communication;Communities;Computer software;Computing Methodologies;Consultations;Counseling;Data;data centers;data management;data platform;Data Reporting;Databases;design;Disease;Doctor of Philosophy;Dose;Educational workshop;Ensure;Environment;Environmental Exposure;Environmental Medicine;Epidemiology;epigenome-wide association studies;Evaluation;evaporation;experience;Exposure to;Feedback;Fostering;Freezing;Funding;Future;gene discovery;gene environment interaction;Genetic study;Goals;Grant;Health;Human;Human Development;Human Resources;improved;indexing;Institution;Label;Laboratories;Leadership;Management Information Systems;Measures;medical schools;meetings;metabolomics;Metadata;Methodology;Methods;Mission;National Institute of Environmental Health Sciences;New York;Nutritional;Occupations;Online Systems;operation;Organization administrative structures;Outcome;outreach;Parents;Participant;Peer Review;Phase;Phenotype;Play;prevent;Prevention;Procedures;Process;programs;prospective;Prospective Studies;Protocols documentation;Public Health;Publications;quality assurance;Quality Control;Recommendation;Reporting;Research;Research Design;Research Personnel;Resources;Running;Sampling;Services;skills;social;Specific Gravity;Specimen;Statistical Data Interpretation;Strategic vision;Structure;Study Subject;success;symposium;System;Testing;Time;Toxicology;United States National Institutes of Health;Urine;user-friendly;Vision;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Urologic Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative Hypospadias, a birth defect of the penis, impacts ~1% of newborn boys each year. Currently, 70% of hypospadias cases remain unexplained and the incidence of hypospadias is increasing. My study addresses this deficiency by studying the biological processes involved in urethral closure.

PI_NAMEs: AMATO, CIRO MAURIZIO (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Ablation;Address;Affect;Androgen Receptor;androgen sensitive;Androgens;Binding;Binding Sites;Biological Assay;Biological Process;boys;career;Cell Communication;cell community;Cell Differentiation process;Cell Physiology;cell type;Cells;Chromatin;Congenital Abnormality;Data;Defect;Development;Enzymes;Epithelium;Etiology;experimental study;Fellowship;fetal;Future;Gene Expression;gene function;Genes;Genetic Transcription;Genome;Grant;Heterogeneity;Human;Hypospadias;Incidence;Institution;Investigation;Knock-out;knockout gene;Knockout Mice;Knowledge;Masculine;Mediating;Mesenchymal;Mesenchyme;Modeling;Morphology;mouse model;Mus;Newborn Infant;novel;Nuclear Orphan Receptor;Occupations;penis;Phase;Phenotype;Population;prevent;Principal Investigator;Process;Regulation;response;Role;SF1;Signal Induction;Signal Transduction;single cell mRNA sequencing;skills;Stanolone;Steroids;Technical Expertise;Testing;Testis;Testosterone;Testosterone 5-alpha-Reductase;Toxin;transcription factor;Tube;Urethra

PROJECT_TITLE: Defining the role of Sf1 in urethral closure

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: Project Narrative This administrative supplement is relevant to public health by supporting a PhD student’s research into how Tobacco-21 laws work, how e-cigarette taxes are avoided, and how mortality patterns have changed since the introduction of e-cigarettes. Thus, the proposed research is relevant to the part of NIH’s mission pertaining to the development of fundamental knowledge used by the United States to prevent diseases caused by tobacco use.

PI_NAMEs: PESKO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: KIMMEL, HEATHER L

PROJECT_TERMS: addiction;Administrative Supplement;Affect;Age;age group;Agreement;American;Appointment;Attenuated;attributable mortality;avoidance behavior;Bite;career development;Cigarette;cohort;Collaborations;combustible tobacco;Complement;Coupled;Dangerousness;Data;Development;Disease;Doctor of Philosophy;doctoral student;Economics;Effectiveness;Electronic cigarette;electronic cigarette use;Elements;Event;Foundations;Funding;Future;Gender;graduate school;graduate student;Health;health economics;Health Policy;Heterogeneity;Indian reservation;Individual;innovation;insight;Internet;Journals;Knowledge;Laws;Legal;Licensing;Life Expectancy;Literature;Marketing;Masks;medical specialties;Mentorship;Mission;model design;mortality;Nicotine;novel;older adult;Paper;parent grant;Pattern;Pediatrics;Peer Review;Policies;prevent;Probability;programs;Public Health;public policy on tobacco;Publishing;Recording of previous events;reduce tobacco use;Regulation;Research;Research Design;Research Personnel;Research Proposals;risk perception;Role;Running;Sales;Severities;Smoking;smoking cessation;Societies;Source;Statutes and Laws;Surveys;Suspensions;symposium;System;Taxation;Taxes;tenure track;Time;Tobacco;Tobacco 21 policies;tobacco control;Tobacco Dependence;tobacco flavor;tobacco products;Tobacco use;Training;treatment effect;United States;United States National Institutes of Health;Universities;Work;Youth

PROJECT_TITLE: Evaluating the Effect of E-cigarette Policies on Youth Tobacco Use

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: NARRATIVE: We propose to conduct research that will determine the impact of relevant behaviors on HIV prevention among Young Black Sexual Minority Men (YBSMM), such as heavy cannabis use. We propose to explore mechanisms, specifically neurocognitive impacts of heavy cannabis use, linking heavy cannabis use to HIV prevention outcomes (and particularly PrEP use), and whether motivations for cannabis use, amidst a changing cannabis regulatory, social acceptance and legal landscape, modify its effects on HIV prevention. Identifying neurocognitive mechanisms through which cannabis use affects HIV prevention and the importance of motivations for cannabis use in understanding clinical outcomes will provide targets for future HIV prevention efforts.

PI_NAMEs: KEEDY, SARAH K;KNOX, JUSTIN ;SCHNEIDER, JOHN  (contact)

PROJECT_TERMS: Affect;AIDS prevention;Alcohols;Behavior;Biological;Black Populations;Black race;Brain;Cannabis;care outcomes;Caring;Chicago;Clinical;cohort;Data;executive function;Future;Health;HIV;Home;Human immunodeficiency virus test;Individual;Legal;Link;marijuana use;Measures;Motivation;Nature;neural;Neurocognition;Neurocognitive;neuroimaging;Outcome;Pharmaceutical Preparations;Plasma;polysubstance use;pre-exposure prophylaxis;Prevention;Prevention program;primary outcome;Research;response;reward processing;Risk;sex;Sex Behavior;sexual minority men;Side;social;substance use;suburb;Support System;Surveys;transmission process

PROJECT_TITLE: Heavy cannabis use, neurocognition and PrEP care engagement among young Black sexual minority men


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The requested supplement is to support the postbaccalaureate research activities and career training of a talented candidate, Ms. Pearl Miller, whose heritage and economic background are underrepresented in biomedical science. Her research addresses the pupillary light response of mammals.

PI_NAMEs: DO, MICHAEL TRI HOANG (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Articulation;Bachelor's Degree;Biophysical Process;Boston;Brain region;career;Cell Nucleus;Cellular biology;constriction;Economics;Environment;experience;experimental study;Foundations;Funding;Goals;interest;Knowledge;Laboratories;Light;Mammals;Measures;medical schools;melanopsin;Miosis disorder;Molecular;Molecular Biology;Mus;parent grant;Pediatric Hospitals;Phototransduction;Physicians;Postbaccalaureate;Presynaptic Terminals;Professional Competence;programs;Property;Pupil;Research;Research Activity;Research Personnel;response;Retinal Cone;Retinal Ganglion Cells;Rod;Science;Sensory;Shapes;Talents;teacher;Tectum Mesencephali;Training;United States National Institutes of Health;Universities;Vertebrate Photoreceptors;Visual System

PROJECT_TITLE: Downstream Actions of Biophysical Mechanisms in the Visual System-Diversity Supplement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MILWAUKEE

ORG_NAME: SOCIETY OF BEHAVIORAL MEDICINE

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE) The Society of Behavioral Medicine’s 45th Annual Meeting & Scientific Sessions, to be held March 13-16, 2024, in Philadelphia, PA, will bring together 1,800 of the nation’s leading behavioral scientists, clinicians, educators, and policymakers to exchange new research on improving health through behavior change, in particular by moving behavioral science upstream. Through a broad range of scientific presentations, discussions, and skill-building workshops, the meeting will facilitate the exchange of the latest population‐level, clinic‐based, and experimental research on the prevention and treatment of the leading causes of morbidity and mortality, with the goals of improving health behaviors, reducing the burden of chronic disease, improving health inequities, lowering healthcare costs, and bettering our nation’s health.

PI_NAMEs: FUEMMELER, BERNARD F (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Address;Affect;Area;Behavior;behavior change;behavior influence;Behavioral;Behavioral Medicine;Behavioral Sciences;Biometry;burden of chronic illness;Cardiovascular Diseases;Cessation of life;Chronic Disease;Chronic lung disease;Clinic;clinical care;Collaborations;Communication;Communities;community partners;Complex;Decision Making;Dedications;Development;Diabetes Mellitus;digital;digital health;Disabled Persons;Discipline;Discipline of Nursing;Discrimination;Disease;Disease Management;disorder prevention;Education;Educational workshop;effective intervention;Epidemiology;ethnic minority;Event;evidence base;Exercise;Exhibits;experimental study;Family;Funding;gender minority;Goals;Government Agencies;Guidelines;Health;Health behavior;Health Care Costs;health equity;health inequalities;Health Promotion;Healthcare;improved;Individual;Industry;industry involvement;industry partner;innovation;Institution;Institutional Racism;Intervention;Knowledge;Laws;Leadership;Malignant Neoplasms;Medical;Medicine;meetings;member;Mentors;mid-career faculty;Minority Groups;Mission;model design;Morbidity - disease rate;mortality;National Cancer Institute;National Heart, Lung, and Blood Institute;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;Outcome;Pathway interactions;Patients;Personal Satisfaction;Persons;Philadelphia;Play;Policies;Policy Maker;Population;posters;prevent;Prevention;Psychology;psychosocial;Public Health;public health relevance;racial minority;Reduce health disparities;Research;Research Design;Research Personnel;Resources;Respiratory Disease;Risk Factors;Role;Science;Scientific Societies;Scientist;sedentary lifestyle;skills;Skin;Societies;Strategic vision;Stress;success;Theoretical model;theories;therapy design;Tobacco use;Training;Translating;United States;Voice;Work

PROJECT_TITLE: Society of Behavioral Medicine 2024 Annual Meeting & Scientific Sessions


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative In the past decade, private equity firms have acquired numerous substance use disorder (SUD) treatment facilities. Similar acquisitions in other areas of health care have resulted in declines in quality and increases in mortality. This project examines the effects of private equity acquisition of SUD treatment facilities on Medicaid beneficiaries’ treatment in opioid treatment programs.

PI_NAMEs: BUSCH, SUSAN H (contact);KING, MARISSA D

PROGRAM_OFFICER_NAME: HAEGERICH, TAMARA

PROJECT_TERMS: addiction;Adolescent;Adult;Area;beneficiary;Buprenorphine;career development;Catalogs;Development;Development Plans;Equity;Faculty;Funding;Geographic Distribution;Goals;health economics;Health Insurance;Health Policy;Healthcare;Insurance Claim Review;Insurance Coverage;Knowledge;Marketing;Measures;Medicaid;Medicine;Mentorship;methadone treatment;mortality;Nature;opioid treatment program;Ownership;parent project;Policies;Positioning Attribute;pre-doctoral;Privatization;Quality of Care;Regulation;Research;Research Personnel;Substance Use Disorder;substance use treatment;Time;Training;treatment center;trend

PROJECT_TITLE: Substance use disorder treatment centers and facility ownership changes


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PI_NAMEs: LAMBERT, CHRISTOPHE G. (contact);YANG, JEREMY JOSEPH

PROGRAM_OFFICER_NAME: KANO, KRISTIN KATHLEEN

PROJECT_TERMS: Area;Biological;Chemicals;Clinical;Communities;Complex;Darkness;Data;Data Coordinating Center;data integration;Data Set;Databases;design;differential expression;Disease;Disparate;Ensure;FAIR principles;Family;Feedback;Funding;G-Protein-Coupled Receptors;gene function;Generations;Genes;genetic variant;Genome;genome resource;Genotype;Genotype-Tissue Expression Project;Goals;human disease;improved;Investments;Ion Channel;Knowledge Management Center;knowledgebase;Manuals;member;multiple data types;Mutation;new therapeutic target;Pathology;Pathway interactions;Phenotype;programs;Protein Kinase;Proteins;Proteome;repository;Resources;Risk;Source;Structure;Technology;Update

PROJECT_TITLE: Illuminating the Druggable Genome Data Coordinating Center - Engagement Plan with the CFDE


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE: OVERALL COMPONENT This program project grant (PPG), called the AIRHEALTH study(Air pollution disrupts Inflammasome Regulation in Heart and Lung Total Health) we will use novel and powerful biotechnologies to uncover the complex of IL-1β and other cellular pathways involved in pollution-associated pathology of the cardiopulmonary system. Understanding the contribution of inflammatory markers to these important public health diseases will lead to the development and application of new ways of preventing and treating air-pollution associated diseases of the pulmonary and cardiovascular systems. By utilizing already collected human samples from individuals of different ethnicities, ages, and genders, we will determine how these factors affect the toxicity response to air pollution, further facilitating personalized medicine.

PI_NAMEs: NADEAU, KARI C. (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Acute;Adolescent;Affect;Age;Air Pollution;air treatment;antagonist;Asthma;Automobile Exhaust;Biological;Biological Markers;Biotechnology;Blood;Blood Pressure;blood pressure elevation;Blood Vessels;Cardiac;Cardiac health;Cardiopulmonary;cardiopulmonary system;Cardiovascular Diseases;Cells;Child;Chronic;Clinical;clinical application;clinical investigation;cohort;Complex;Data;data sharing;Dependence;Development;Diesel Exhaust;Disease;disorder risk;effective therapy;Ensure;Environmental Exposure;Environmental Pollution;Epithelium;Equipment;Ethnic Origin;experimental study;Exposure to;fine particles;forest fires;Future;Gender;global health;Goals;Health;Heart;heart cell;Heart Diseases;Human;Immune;Immune System Diseases;immunopathology;improved;Individual;induced pluripotent stem cell;Inflammasome;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;innovation;Interleukin Activation;Interleukin-1 beta;Investigation;Knowledge;Ligands;Link;Lung;Lung Diseases;lung health;Mentors;Modeling;Molecular;Monitor;multidisciplinary;novel;Outcome;Particulate Matter;Pathogenesis;Pathology;Pathway interactions;personalized medicine;Pharmaceutical Preparations;Policies;pollutant;Pollution;prevent;Program Research Project Grants;programs;Proteomics;Public Health;Pulmonary Heart Disease;Regulation;Research Personnel;Resources;response;Sampling;Shapes;success;Sum;synergism;System;Systems Biology;Testing;Tissues;Toxic effect;Training;Wildfire

PROJECT_TITLE: Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH)


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Lung;Social Determinants of Health

PROJECT_TERMS: Air Pollution;Applications Grants;Cardiopulmonary;Communication;cost effectiveness;Ensure;Future;General Population;Goals;Health;Heart;Inflammasome;Inflammation;Information Dissemination;lectures;Lung;meetings;member;Monitor;National Heart, Lung, and Blood Institute;Occupational activity of managing finances;Office of Administrative Management;operation;Pathology;Performance;Procedures;Process;Productivity;programs;Publications;Quality Control;Regulation;Reporting;Research;Resources;Schedule;Services;social media;sound;symposium;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: Administrative Core for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: DESAI, MANISHA  (contact)

PROJECT_TERMS: Address;Air Pollution;Ancillary Study;Area;Bioinformatics;bioinformatics tool;Biological Markers;Biometry;Clinical;Clinical Data;clinical phenotype;Clinical Research;Clinical Trials Design;Code;Collaborations;Computer software;Custom;Data;Data Analyses;Data Analytics;Data Collection;data de-identification;Data Element;data integration;data integrity;data management;Data Science;Data Set;Databases;design;Disparate;electronic data;Ensure;Goals;Health;Health Insurance Portability and Accountability Act;Health protection;Heart;Housing;Human;Human Resources;human tissue;Inflammasome;innovation;Interdisciplinary Study;Internet;Joints;Knowledge;large datasets;longitudinal analysis;Longitudinal Studies;Lung;Manuscripts;member;Metadata;Methodology;Modeling;Modernization;Monitor;Participant;Pathology;Patients;Preparation;Production;Program Research Project Grants;programs;Publications;quality assurance;Quality Control;Regulation;Reproducibility;Reproducibility of Results;Research;Research Design;Research Personnel;Research Project Grants;Research Subjects;Resources;Sampling;Science;Secure;Services;Site;sound;Specific qualifier value;Statistical Data Interpretation;Statistical Methods;System;Testing;time orientation;timeline;tool;Work

PROJECT_TITLE: Data Management and Analysis Core (DMAC) for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study


NIH_SPENDING_CATS: Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Lung;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PROJECT_TERMS: Acute;Age;Air;Air Pollution;alveolar epithelium;antagonist;Apoptosis;Area;Asthma;ATAC-seq;Automobile Driving;Biological Assay;Blood specimen;Body mass index;Cardiac;Cardiopulmonary;Cells;Characteristics;chemokine;Chronic;Chronic lung disease;Clinical;cohort;cytokine;cytotoxicity;Data;data sharing;Development;Disease;DNA Methylation;Environment;Epigenetic Process;Epithelial Cells;Epithelium;ethnic diversity;experience;exposed human population;Exposure to;Goals;Health;Heart;Heart Diseases;Heterogeneity;high dimensionality;Histones;Human;Immune;immune activation;Immune system;improved;Incubated;Individual;Inflammasome;Inflammation;Inflammatory;inflammatory marker;inhibitor;Injury;Interleukin-1 beta;Ligands;Link;Liquid substance;Lung;Lung Diseases;Measures;Mediating;Medical;Modification;novel;novel strategies;Outcome;Oxidative Stress;Participant;Particulate Matter;Pathogenesis;Pathology;Pathway interactions;patient population;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Plasma;Pollution;Population;Post-Translational Protein Processing;prevent;Proliferating;Public Health;Pulmonary alveolar structure;Pulmonary function tests;Pulmonary Pathology;Regulation;response;Risk;Sampling;sex;Signal Transduction;stem cells;Structure of parenchyma of lung;synergism;Techniques;Testing;Time;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Underserved Population;Validation;Visit

PROJECT_TITLE: Project 1 for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study


NIH_SPENDING_CATS: Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Heart Disease;Lung;Social Determinants of Health

PI_NAMEs: KASOWSKI, MAYA  (contact)

PROJECT_TERMS: Acute;Air Pollution;ATP phosphohydrolase;Biochemical;Biological Assay;Biological Markers;Blood;Blood specimen;Cardiac;Cardiovascular system;Cell Physiology;Cells;Chronic;cohort;Complex;cytokine;Data;differential expression;Dimensions;Disease;Drug Targeting;Engineering;experimental study;Exposure to;Functional disorder;Gene Expression;gene network;Genes;Glucokinase;Health;Heart;heart cell;Heart Diseases;Heat-Shock Proteins 70;Immune;Immune response;Immune signaling;Immune system;Individual;Inflammasome;Inflammation;Inflammatory;innovation;Interleukin-1 beta;Knowledge;laboratory experiment;Link;lipid biosynthesis;lipid metabolism;liquid chromatography mass spectrometry;Lung;Lung Diseases;Mass Spectrum Analysis;Mediator;Metabolic;metabolome;metabolomics;Methods;Molecular;molecular modeling;Participant;Pathologic;Pathway interactions;Pattern;Peripheral Blood Mononuclear Cell;Plasma;Pollution;programs;Proteins;Proteome;Proteomics;Regulation;Reporting;response;Role;Sampling;Signal Transduction;small molecule;synergism;Systems Biology;Testing;therapy development;Time;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomic profiling;Work

PROJECT_TITLE: Identifying Multidimensional Omics Profiles Associated with Cardiovascular and Pulmonary Responses to Chronic and Acute Air Pollution Exposure (Project 2) for AIRHEALTH Study


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Lung;Prevention;Regenerative Medicine;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: LIAO, RONGLIH  (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Affect;Age;Air Pollutants;Air Pollution;Anti-Inflammatory Agents;Antiinflammatory Effect;Area;Arrhythmia;Asthma;biobank;Biological Assay;Blood Circulation;Calcium;Cardiac;cardiac tissue engineering;Cardiopulmonary;Cardiotoxicity;Cardiovascular Models;cardiovascular risk factor;Cardiovascular system;Cell Survival;cell type;Cells;cerebrovascular;Chronic;cohort;cytokine;Cytokine Signaling;Development;Diameter;disease model;drug discovery;drug testing;Endothelial Cells;Environmental Health;Ethnic Origin;Exposure to;FDA approved;Fibroblasts;Gender;Gene Expression;Genetic Variation;genotoxicity;Health;Heart;high throughput screening;Human;human induced pluripotent stem cells;Immune signaling;Immune system;improved;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inflammasome;Inflammation;Inflammatory;innovation;Interleukin-1;Interleukin-1 beta;Knowledge;Lung;lung injury;Medical;Mitochondria;Modeling;Molecular;Morbidity - disease rate;Morphology;mortality;Myocardial Ischemia;novel;Organ;Oxidative Stress;Particulate Matter;Pathologic;Pathway interactions;Patients;Penetration;Peripheral Blood Mononuclear Cell;personalized medicine;Pharmaceutical Preparations;Physiological;pollutant;Pollution;prevent;Prevention;Race;racial diversity;recruit;Regulation;Repression;respiratory;response;Risk;Sampling;Serum;Signal Pathway;Stroke;Study models;Sudden Death;Testing;Tissue Engineering;Tissue Model;Tissues;Toxic effect;transcriptome;Wildfire;World Health Organization

PROJECT_TITLE: Modeling Cardiovascular Risks of Air Pollutants with Human Induced Pluripotent Stem Cell-Derived Cardiovascular-Associated Cells (Project 3) for the Air pollution disrupts Inflammasome Regulation in


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative This funding is critical for the preservation and continuation of support for these unique cohorts that provide invaluable participant samples to forward the strategic scientific goals of the PAVE MDC. At the time of the UM1 application, we were fortunate that these investigator-initiated cohorts were supported by individual R01 grant funding or the EPIICAL Consortium funded by ViiV Healthcare. Funding for these cohorts through the R01 mechanism and the EPIICAL consortium have terminated, thereby presenting a large gap in funding. The request is for consideration to support three existing cohorts within PAVE.

PI_NAMEs: CHAHROUDI, ANN M;PERSAUD, DEBORAH  (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adaptive immune response;Adolescent;assay development;Autologous;Blood specimen;Cells;Child;Childhood;cohort;Cohort Studies;Collaborations;collaboratory;cost;Development;Development Plans;Disease remission;Enrollment;Exposure to;Family;Female;Funding;Goals;Gold;Gossypium;Grant;Health;Healthcare;HIV;HIV Infections;Immune response;in utero;Individual;Infant;Innate Immune Response;Innate Immune System;insight;Maintenance;male;Mothers;Mozambique;neuroimaging;novel;Outcome;Participant;pediatric human immunodeficiency virus;peer support;perinatal HIV;Perinatal Infection;Predisposition;preservation;Reporting;Research;Research Personnel;Research Project Grants;Sampling;Sampling Studies;Schedule;Sex Differences;single cell technology;Site;South Africa;Spinal Tap;Support Groups;Time;Universities;Virus;Visit;Wit

PROJECT_TITLE: Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney Collaboratory


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Estrogen;Neurosciences;Substance Misuse;Tobacco;Women's Health Research

ORG_CITY: EL PASO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the findings are expected to constitute an important step toward elucidating the larger neuronal substrates that promote addiction pathology in women. The proposed studies are relevant to the part of the NIH mission that pertains to supporting research aimed at reducing the burden of substance use disorders, especially in women who are most vulnerable to the long-term negative health consequences of chronic nicotine use.

PI_NAMEs: ODELL, LAURA ELENA (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: addiction;Adult women;anxiety-like behavior;base;Behavior;Behavioral;biological adaptation to stress;Chronic;Clinical;Corticotropin-Releasing Hormone;Data;design;Development;Economics;electronic cigarette use;Electronic Nicotine Delivery Systems;Epidemic;Estradiol;Evidence based intervention;experience;Female;Future;gamma-Aminobutyric Acid;Gene Transfer;Goals;Gonadal Hormones;Habenula;Health;Hormones;Human;immunocytochemistry;improved outcome;Inhalation;innovation;insight;interdisciplinary approach;Interneurons;interpeduncular nucleus;Intervention;Knowledge;Learning;Literature;male;Measures;Medial;Mediating;men;Methods;Mission;negative affect;neurochemistry;Neurons;Neurotransmitters;Nicotine;nicotine exposure;nicotine use;nicotine vapor;Nicotine Withdrawal;novel;Outcome;Ovarian hormone;parent grant;Pathology;Pathway interactions;Peptides;Pharmaceutical Preparations;Play;Population;Precision therapeutics;Predisposition;Production;Progesterone;programs;Public Health;Rattus;receptor;receptor expression;Reduce health disparities;Reporting;Research;Research Support;Rodent;Severities;sex;Sex Differences;Stress;Substance Use Disorder;System;Technology Transfer;Tobacco use;United States National Institutes of Health;Withdrawal;Withdrawal Symptom;Woman;women versus men;Work

PROJECT_TITLE: Sex Differences and The Influence of Ovarian Hormones on the Mechanisms that Promote Nicotine Withdrawal


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Cerebrovascular;Coronaviruses;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Narrative COVID-19 is increasingly recognized as a risk factor for vascular contributions to cognitive impairment and dementia, VCID. The mechanisms by which COVID-19 promotes vascular dementia are unclear. Our proposed research using mechanistic mouse models will investigate how modifications to brain endothelial cells caused by SARS-CoV-2 infection can promote development of vascular dementia by destabilizing the blood-brain barrier. These studies will establish novel targetable mechanisms to prevent or treat vascular dementia after infection.

PI_NAMEs: LUTZ, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 2019-nCoV;Acceleration;Acute;ATAC-seq;beta catenin;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier permeabilization;brain endothelial cell;Cells;cerebrovascular;Cerebrovascular system;Clinic;Cognition;COVID-19;COVID-19 pandemic effects;Critical Pathways;Data;Dementia;Development;Endothelial Cells;Endothelium;Engineering;Epigenetic Process;Extravasation;Felis catus;Functional disorder;Future;gene therapy;Genes;Genetic;Goals;Grant;High Fat Diet;high risk;Human;Hypertension;Impaired cognition;in vivo;Individual;Infection;Inflammation;Inflammatory;inhibitor;Knowledge;Ligands;macromolecule;Modification;mouse model;Mus;neuroinflammation;neurotoxic;novel;novel strategies;Pathogenicity;Pathway interactions;Pattern;Pericytes;Permeability;Phenotype;post SARS-CoV-2 infection;prevent;programs;promote resilience;Public Health;Recording of previous events;Research;Resistance;respiratory;response;Risk;Risk Factors;Role;SARS-CoV-2 infection;Severities;Signal Transduction;small molecule;Testing;Therapeutic;therapeutic target;transcriptome sequencing;Translating;vascular cognitive impairment and dementia;Vascular Dementia;vascular stress;Viral

PROJECT_TITLE: Impact of SARS-CoV-2 on the cerebrovasculature as a risk factor for VCID: Role of Wnt/beta-catenin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-M(91)]


ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative It is important to convene CFAR members at the forefront of HIV research, providing a unique opportunity to present recent findings and advances in HIV/AIDS research. Additionally, the meeting is an ideal forum to build on and strengthen collaborative research between senior faculty and ESIs. Inclusion of the National CFAR Community Advisory Board (CAB) Coalition (N3C) offers an opportunity for community stakeholders to be informed of emergent research that will directly impact the wellbeing of their communities, as well as providing feedback to the CFARs as to how to effectively engage with their local communities.

PI_NAMEs: GOLDSTEIN, HARRIS  (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Administrator;Businesses;Bylaw;Collaborations;Communication;Communities;community advisory board;Community Networks;Development;Discipline;Educational workshop;Faculty;Feedback;Funding;Future;Goals;Grant;HIV;HIV/AIDS;innovation;Institution;Learning;meetings;member;Mentors;Mission;New York City;Personal Satisfaction;Policies;Productivity;programs;Reporting;Research;Research Personnel;senior faculty;Site;Strategic Planning;symposium;synergism;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: ERC Einstein-Rockefeller-CUNY Center for AIDS Research


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Climate-Related Exposures and Conditions;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

PHR: Project Narrative Traffic related air pollution (TRAP) is strongly associated with an increased risk for neurodegenerative disease, such as Alzheimer’s Disease (AD) and AD-related dementias (ADRD); however, since TRAP is a complex mixture of particulate matter (PM) and gases, it is not known which component is primarily responsible for promoting neurodegenerative disease, or how it does so. One goal of this Diversity supplement is to investigate the relative neurotoxicity of TRAP-derived PM vs. gases, the role of microglia in mediating the neurotoxic effects of TRAP, and the influence of sex and genotype on microglial response to TRAP. A second goal is to increase the diversity of the scientific community with the training needed to conduct rigorous scientific research focused on identifying and understanding environmental risk factors associated with neurodegenerative diseases in order to develop strategies for promoting healthy brain aging.

PI_NAMEs: BEIN, KEITH ;LEIN, PAMELA J (contact);VAN WINKLE, LAURA S

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: aging brain;air filter;Air Pollution;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;Animals;Astrocytes;astrogliosis;Brain;California;career;career networking;Cd68;Chronic;Coculture Techniques;Communities;Complex Mixtures;Data;Ensure;entorhinal cortex;Environmental Risk Factor;epidemiology study;exposed human population;Exposure to;fine particles;Gases;Generations;Genotype;glial activation;Glial Fibrillary Acidic Protein;Goals;Hippocampus;Human;In Vitro;in vivo;Industrialization;Knowledge;Lung;Mediating;Microglia;Modeling;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;neurotoxic;neurotoxicity;novel;parent grant;particle;Particulate Matter;Pathology;Phenotype;Predisposition;Preparation;Rattus;Reporting;Research;Research Activity;response;Risk;Role;sex;skills;Source;Technical Expertise;Testing;Time;traffic-related air pollution;Training;ultrafine particle;Urbanization;Vehicle Emissions;Work

PROJECT_TITLE: Diversity Supplement toTraffic-related air pollution exacerbates AD-relevant phenotypes in a genetically susceptible rat model via neuroinflammatory mechanism(s)


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE The five multidisciplinary research Programs and nine Shared Resources in the SJCCC work together to find cures for pediatric cancer, while minimizing the long-term side effects of treatment. With strong institutional and philanthropic support, for 56 years we have served as a national and international resource for health care providers, children with cancer, and their families.

PI_NAMEs: ROBERTS, CHARLES  (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Acceleration;Address;aged;American;anti-cancer research;Area;Automobile Driving;Basic Cancer Research;Basic Science;biomedical referral center;Brain Neoplasms;Budgets;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Patient;cancer prevention;Cancer Survivor;Cancer Survivorship;care providers;Caring;Catchment Area;Cessation of life;Charities;Child;childhood cancer survivor;Childhood Cancer Treatment;Classification;Clinical;Clinical Research;clinical trial enrollment;Collaborations;Communities;Comprehensive Cancer Center;Country;curative treatments;data centers;Dedications;design;Development;Developmental Biology;Direct Costs;Disease;Education;Enrollment;experience;Extramural Activities;Faculty;Family;Fostering;Funding;Genomics;Goals;graduate school;Growth;Guidelines;Health Resources;Heart;Hematologic Neoplasms;Housing;improved;improved outcome;Infrastructure;innovation;Inpatients;Institution;inter-institutional;Interdisciplinary Study;International;Intervention Studies;Investigation;investigator-initiated trial;Investments;Journals;Laboratories;Laboratory Research;Location;Longterm Follow-up;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuscripts;member;Mission;National Cancer Institute;NCI Center for Cancer Research;Neurobiology;next generation;novel;novel therapeutic intervention;Outcomes Research;Outpatients;outreach;Paper;Pediatric Hematology;Pediatric Oncology;pediatrician;Peer Review;precision medicine;programs;Protocols documentation;Publications;Publishing;Quality of life;recruit;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Saint Jude Children's Research Hospital;Science;side effect;Site;Solid Neoplasm;Strategic Planning;student training;Survivors;survivorship;Therapeutic;Therapeutic Clinical Trial;Translating;translational goal;translational pipeline;Translational Research;Translations;Treatment Side Effects;United States National Institutes of Health;Work;World Health Organization;young adult

PROJECT_TITLE: Cancer Center Support Grant (CCSG)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE OFFICE OF PUBLIC HEALTH

ORG_STATE: LA

PHR: Project Narrative Funding under the Flexible Funding Model will allow the Louisiana Department of Health/Office of Public Health to continue working under full conformance with the Manufactured Food Regulatory Program Standards by building capacity in our food safety program. The focus will be on the protection of the public health in collaboration with the Food and Drug Administration and other stakeholders as part of a nationally-integrated food safety system.

PI_NAMEs: WARREN, BRIAN RAY (contact)

PROGRAM_OFFICER_NAME: RAMOS, JOCELYN

PROJECT_TITLE: Application for MFRPs Funding for the Louisiana Department of Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 ORA-T (05)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Genetics;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Estrogen receptor gene (ESR1) mutations are found at up to 38% frequency in metastatic breast cancer, and exhibit resistance to endocrine therapy (ET), limiting durable clinical management of the disease. This project will investigate the transcriptional and clonal evolution of ESR1 mutations in metastatic and ET-resistant disease using a combination of bioinformatics and experimental validation. There are currently no approved therapies specific for ESR1 mutant breast cancer, and this proposal lays essential groundwork for mutant- specific therapeutic targeting to prolong metastasis-free survival and ET sensitivity.

PI_NAMEs: HERZOG, SARAH  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;Aromatase Inhibitors;Automobile Driving;Bioinformatics;Biological Assay;Breast Cancer Patient;Candidate Disease Gene;cell growth;Cells;ChIP-seq;Clinical;Clinical Management;Clonal Evolution;Computational Biology;Computer Analysis;Computing Methodologies;Data;Development;Disease;Disease Management;Disease Progression;Disease Resistance;DNA;DNA sequencing;Enzyme Inhibitor Drugs;Estrogen receptor positive;Estrogen Receptors;Estrogens;Evolution;Exhibits;FDA approved;Frequencies;Gene Mutation;Genetic Transcription;Goals;Growth;Growth Factor Receptors;hormonal signals;hormone therapy;improved;In Vitro;in vivo;Induced Mutation;inhibitor;Knowledge;Laboratories;Malignant Breast Neoplasm;Malignant Neoplasms;MAP Kinase Gene;Metastatic breast cancer;Metastatic malignant neoplasm to brain;metastatic process;Modeling;mortality;mutant;Mutation;Neoplasm Metastasis;Oncogenic;Other Genetics;Outcome;Pathway interactions;Patients;Phenotype;Pilot Projects;pressure;Prevalence;Primary Neoplasm;Proliferating;Publishing;Receptor Gene;Recurrence;Recurrent disease;Resistance;resistance mechanism;RNA;Signal Pathway;Site;Somatic Mutation;standard of care;targeted treatment;Testing;therapeutic target;therapy resistant;transcriptional reprogramming;transcriptome sequencing;Treatment Efficacy;tumor;United States;Validation;Woman

PROJECT_TITLE: TRANSCRIPTIONAL REPROGRAMMING OF ESR1 MUTANT BREAST CANCER IN METASTASIS AND TREATMENT RESISTANCE


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Prevention

PHR: PROJECT NARRATIVE Increasingly, prevention-minded gerontologists and geroscientists look to midlife as the life stage offering a terrific opportunity to prevent or delay the multiple diseases that shrink older adults’ health span, and they call for more knowledge about aging during midlife. We propose to follow up at age 52 a cohort of 1037 infants studied since birth, the Dunedin Study, to quantify how fast or slowly each cohort member is aging in each of 8 different life domains: the pace of biological aging, functional aging, facial aging, social aging, sexual aging, inflammatory aging, microvascular aging, and cognitive aging (Aim 1). We will generate new knowledge about the early-life antecedents of each of the 8 kinds of aging (Aim 2), and about the risk each kind of aging poses for late-life disease (Aim 3), and we will export to the field DNAmethylation blood-test measures of 8 kinds of aging.

PI_NAMEs: CASPI, AVSHALOM ;MOFFITT, TERRIE E (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;Aging;aging related;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Animals;Anxiety;Arousal;Asthma;Back;balance testing;Behavioral;Belief;Binding;Biological Markers;Birth;Black race;Blood;Blood Tests;Caliber;Cardiovascular Physiology;Childhood;childhood adversity;Cities;Cognitive aging;cohort;Collaborations;Communities;critical period;Data;Data Set;Dementia;Dental;deprivation;Development;Diagnosis;Discipline;Disease;Dissociation;DNA Methylation;Erectile dysfunction;ethnic diversity;Ethnic Population;experience;Face;Fetal Growth;follow-up;Frequencies;Funding;Gait speed;Geroscientist;Goals;Hand Strength;Health;Health Status;healthspan;Heterogeneity;high reward;high risk;Image;Immune;Immune response;In Vitro;Individual;Individual Differences;Infant;Inflammatory;inflammatory marker;innovation;Intercept;Interleukin-6;Kidney;Knowledge;late life;Latinx;Life;Life Cycle Stages;Loneliness;Longitudinal Studies;Lung;Measures;member;Menopause;Mental disorders;Metabolic;Methods;Methylation;microvascular aging;middle age;mild cognitive impairment;Mind;Modeling;multidisciplinary;Names;novel;Obesity;older adult;Ophthalmoscopy;Outcome;Pain;Participant;participant enrollment;peer;Persons;Phase;pre-clinical;prevent;Prevention;Process;programs;prospective;psychosocial;Puberty;Publishing;rate of aging;Reporting;Research;retina blood vessel structure;Risk;satisfaction;Sexually Transmitted Diseases;Smoking;social;Social isolation;Social support;success;System;Testing;Time;Trail Making Test;Urinary Incontinence;vaginal dryness;Verbal Learning;Walking;Work;young adult

PROJECT_TITLE: Aging in 1000 healthy midlife adults: Phase 52 of the Dunedin Study

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative: Overall The overall objective of the Penn State TCORS is to provide a science base for reducing the harm from tobacco products. We are pursuing the Food and Drug Administration’s Comprehensive Plan for Tobacco and Nicotine Regulation by determining the toxicity of aerosols, smoke, and oral exposures of tobacco products that may be used as substitutions for cigarettes. This includes identifying the specific characteristics of non- cigarette products that can be regulated to reduce harm.

PI_NAMEs: FOULDS, JONATHAN ;MUSCAT, JOSHUA E (contact)

PROGRAM_OFFICER_NAME: HERRMANN, EVAN SULLIVAN

PROJECT_TERMS: addiction;Address;Aerosols;Affect;Analytical Chemistry;Area;authority;base;Basic Science;Biological;Biological Markers;Biometry;career development;Career Mobility;Characteristics;Chemicals;Cigar;Cigarette;Clinical Research;Collaborations;combustible tobacco;Communication;Communities;Data;data management;design;Development;Devices;Education;Electronic cigarette;electronic cigarette user;electronic liquid;Emerging Tobacco Products;epidemiologic data;experience;exposed human population;Flavoring;Free Radicals;Harm Reduction;Health;Inhalation;Knowledge;Laboratory Animal Models;Laboratory Study;Length;Marketing;Measurement;Measures;Mentors;Methodology;Methods;Mission;multidisciplinary;Nicotine;Nitrates;non-cigarette tobacco product;novel;novel marker;Oral;Oxidants;Oxidative Stress;Persons;Pilot Projects;Placebos;Production;programs;Randomized Controlled Clinical Trials;Regulation;Research;research and development;Research Design;Research Infrastructure;Research Methodology;Research Project Grants;Research Support;Resource Development;Resources;Risk;Role;Sampling;Science;Scientist;Senior Scientist;Series;Smoke;Smoker;Source;stem;student training;System;Temperature;Testing;Time;Tobacco;tobacco exposure;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco smoke;tobacco toxicant;Tobacco use;Toxic effect;Translational Research;translational study;United States Food and Drug Administration;ventilation;Work

PROJECT_TITLE: Penn State TCORS: Tobacco Product Composition Effects on Toxicity and Addiction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE We will use falsifiable forecasting, mathematical modeling and statistical methods to help world-health partner organizations identify when and where Trachoma (a blinding disease) will be eliminated as a public health problem worldwide. This includes modeling approaches for resolving persistent infection in hot spot areas, and improving surveillance to detect any resurgence of disease.

PI_NAMEs: LIETMAN, THOMAS M (contact);PORCO, TRAVIS CHRISTIAN

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TITLE: Forecasting Trachoma Control

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Aging

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The University of Alabama at Birmingham Nathan Shock Center of Excellence in the Basic Biology of Aging will continue to provide state-of-the-art research services as well as diverse cells and animals for researchers investigating the links between energetics, health span and the aging as well as provide education and training in bioenergetics theory and analysis from the level of the organelle to the cell, tissue, organ, and organism.

PI_NAMEs: AUSTAD, STEVEN N. (contact);BUFORD, THOMAS W

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Adipose tissue;Affect;Aging;aging mechanism;aging process;Alabama;Ally;Animal Model;Animals;Autophagocytosis;Bioenergetics;Biology of Aging;Bivalvia;Body Composition;Body System;Brown Fat;Cell Aging;Cell Energetics;Cell Nucleus;Cell Physiology;Cells;Chronic Disease;Collaborations;Communication;Communities;comparative;Comparative Biology;Complex;Country;Cytoplasm;Data Analytics;Data Set;detection of nutrient;Discipline;Disease;Dissection;DNA Repair;Education;Elephants;energy balance;Environment;Expenditure;Experimental Designs;experimental study;Fishes;fly;Fostering;FRAP1 gene;gene network;Geroscience;Glycolysis;Goals;Health;health assessment;healthspan;Infrastructure;innovation;Instruction;instrumentation;Insulin;Intake;interest;International;Laboratories;late life;Life;Link;Longevity;Malignant Neoplasms;Mammals;Measurable;Metabolic;metabolic abnormality assessment;Metabolic Pathway;metabolic rate;Metabolism;metabolomics;Methodology;Mitochondria;Mitochondrial DNA;Modeling;Modernization;Mole Rats;Morphology;Mus;novel;Nuclear;Nutrient;Organ;Organelles;Organism;outreach;Oxidative Phosphorylation;Oxidative Stress;Oxygen;Pattern;Physical activity;Population;Process;Production;Productivity;programs;proteostasis;Rattus;reduced food intake;Regulation;repaired;Research;research and development;Research Infrastructure;Research Personnel;Resources;response;Services;Shock;Signal Transduction;symposium;Techniques;Technology;Temperature;theories;tissue regeneration;Tissues;Training;Training and Education;Training Support;Twin Multiple Birth;Universities;Update;Variant;virtual;Whole Organism

PROJECT_TITLE: Comparative Bioenergetics of Aging


NIH_SPENDING_CATS: Neurosciences;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PHR: PROJECT NARRATIVE The Notch signaling pathway has been implicated in a wide range of biological and pathological processes. Using the Drosophila ovarian model, the proposed studies will lead to improved understanding of the diverse effects and regulatory mechanisms of Notch signaling during development and tissue homeostasis. The findings from the proposed studies will help designing new therapeutic strategies for diseases related to aberrant Notch signaling.

PI_NAMEs: DENG, WU-MIN  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Back;Biological;Biological Models;Biological Process;Cell Communication;Cell Cycle;Cell Death;Cell Differentiation Induction;cell growth;Cell Physiology;Cell Polarity;Cell Proliferation;Cell Survival;Cells;Cessation of life;design;Development;Disease;Drosophila genus;egg;Ensure;Environmental Risk Factor;environmental stressor;Epithelial Cells;Event;Feedback;Feeds;Genes;Genetic;Germ Cells;Germ Lines;Growth;Homeostasis;Homologous Gene;human disease;improved;MAPK8 gene;Mitotic;Mitotic Cell Cycle;Modeling;Molecular;neuronal cell body;notch protein;Notch Signaling Pathway;novel;novel therapeutic intervention;Nuclear;Oocytes;Oogenesis;Output;Ovarian;Pathogenesis;Pathologic;Pathologic Processes;Pathway interactions;Phagocytes;Phagocytosis;Physiological;Play;programs;Regimen;Regulation;Role;Series;Signal Induction;Signal Transduction;Somatic Cell;System;Temperature;Testing;Tissues;Tumor Suppressor Proteins;Up-Regulation

PROJECT_TITLE: Notch signaling and germline-soma interactions in the Drosophila ovarian model

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Substance Misuse

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: Project Narrative There is a public health need to develop novel, culturally adapted interventions to reduce alcohol consumption among Latinx hazardous drinkers with comorbid clinical anxiety. The proposed R01 study will draw upon National Institutes of Health (NIH) treatment development guidelines (Stage 1) to translate and innovate past work to address a major public health priority. Specifically, we propose to develop (Phase IA) and test (Phase IB) the effectiveness of a brief, integrated, single-session, computer-based, culturally adapted personalized feedback intervention (PFI) designed to enhance knowledge regarding adverse anxiety-alcohol interrelations, increase motivation and intention to reduce hazardous drinking, and reduce positive attitudes and intention regarding anxiety-related alcohol use among Latinx hazardous drinkers with anxiety within community-based health clinics.

PI_NAMEs: ZVOLENSKY, MICHAEL J. (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: acceptability and feasibility;Address;alcohol abuse therapy;Alcohol consumption;alcohol misuse;alcohol misuse prevention;alcohol related consequences;alcohol use disorder;Alcohols;Anxiety;anxiety management;anxiety reduction;anxiety symptoms;Area;Attitude;Basic Science;Behavior Therapy;biobehavior;brief intervention;Caring;Clinic;clinical anxiety;Clinical Trials Design;Community Health;comorbidity;compare effectiveness;Computers;coping;cost;COVID-19;culturally appropriate intervention;Data;demographics;design;Development;Disease;Disparity;drinking;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness trial;ethnic discrimination;Expectancy;experience;Feedback;Female;Focus Groups;follow-up;Frequencies;Goals;Guidelines;hazardous drinking;Health;health care settings;health disparity;health disparity populations;health inequalities;Health Services Accessibility;Impairment;improved;innovation;Intention;Intervention;intervention effect;intervention refinement;Knowledge;Latinx;Latinx population;Literature;male;Mediating;Mediator;Modeling;Motivation;National Institute on Alcohol Abuse and Alcoholism;novel;optimism;Outcome;Participant;personalized normative feedback;Phase;point of care;Population;Populations at Risk;Prevalence;psychoeducation;Public Health;public health priorities;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Reporting;Research;Research Project Grants;Research Support;Sampling;Severities;Standardization;Strategic Planning;Symptoms;Testing;therapy design;therapy development;Translating;Treatment Cost;Underserved Population;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Latinx Hazardous Drinkers with Clinical Anxiety: Effectiveness Trial of a Personalized Normative Feedback Intervention