NIH_SPENDING_CATS: Biotechnology;Cooley's Anemia;Gene Therapy;Genetics;Hematology;Orphan Drug;Rare Diseases;Sickle Cell Disease

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative (Public) Red blood cells produce hemoglobin, which carries oxygen throughout our body. Inherited disorders of hemoglobin are among the most common diseases worldwide. We seek to turn back on the fetal form of hemoglobin in adults with hemoglobin disorders. Our work explores ways to remove the protein that silences fetal hemoglobin expression as a new therapy.

PI_NAMEs: ORKIN, STUART H (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: activity-based protein profiling;Acute;Address;Adult;Affect;Back;base editing;beta Thalassemia;Binding;Binding Sites;burden of illness;CD34 gene;Cell Cycle;Cells;Chemicals;Clinical;Clinical Trials;CRISPR/Cas technology;Data;derepression;Development;Disease;Down-Regulation;Erythrocytes;Erythroid;Erythroid Cells;Evolution;Fetal Hemoglobin;Fetal Proteins;Gene Delivery;Gene Expression;Gene Modified;gene therapy;Gene therapy trial;Genes;Genetic Transcription;Geographic Locations;global health;Globin;Goals;Hematology;Hematopoietic;Hemoglobin;Hereditary Disease;in vivo;innovation;Laboratories;Ligands;Medical;Methods;Methylation;Modality;nanobodies;Nature;novel;novel therapeutic intervention;novel therapeutics;Oxygen;Patients;Pharmaceutical Preparations;pharmacologic;Phase;preconditioning;Procedures;Production;promoter;protein degradation;Proteins;reconstitution;Research;Resolution;Resources;Role;Sickle Cell Anemia;small hairpin RNA;small molecule;small molecule therapeutics;symptomatology;temporal measurement;Therapeutic;therapeutic target;tool;Transfusion;TRIM Gene;ubiquitin-protein ligase;Validation;Vision;Work

PROJECT_TITLE: DEGRADATION OF BCL11A PROTEIN FOR HbF REACTIVATION

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: CORE 008 – GENOME EDITING SHARED RESOURCE PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Genome Editing Shared Resource.

PI_NAMEs: MAGNUSON, MARK A (contact)

PROJECT_TERMS: Accidents;Animal Experimentation;Animals;assisted reproduction;Biological;Birth;blastocyst;Breeding;Cancer Center;Cancer Center Support Grant;Cells;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communities;Complex;cost;cost effective;CRISPR/Cas technology;Cryopreservation;Cytoplasm;Derivation procedure;design;Disasters;DNA;Effectiveness;Embryo;embryo cryopreservation;Embryo Transfer;embryonic stem cell;Engineering;Ensure;Epitopes;Experimental Designs;experimental study;Female;Fertilization in Vitro;Gene Deletion;Gene Modified;Gene Targeting;gene-editing approach;Generations;Genes;genome editing;Genomic approach;Genotype;Germ;germ free condition;Goals;Heterozygote;improved;Individual;Injections;Institution;Insurance;Knowledge;Mammalian Oviducts;Mediating;medical schools;member;Mentors;Mentorship;Methods;Microinjections;Mission;Modeling;Modification;Molecular Biology;Mouse Embryonic Stem Cells;mouse model;Mus;Mutant Strains Mice;NCI Center for Cancer Research;NIH Mouse;Nonhomologous DNA End Joining;novel;operation;Outcome;Point Mutation;Policies;Preparation;preservation;programs;Proteins;Publishing;pup;Qualifying;Reagent;reconstitution;repaired;Reporting;repository;Reproducibility;Reproductive Techniques;Research;Research Personnel;Resource Sharing;Resources;responsible research conduct;Ribonucleoproteins;Sampling;screening;Service delivery model;Services;Shipping;Single-Stranded DNA;skills;Source;sperm cryopreservation;Students;success;Technology;Tennessee;Time;Training;Transgenic Mice;Tumor Biology;Universities;Uterus;Validation

PROJECT_TITLE: Genome Editing Shared Resource

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Muscular Dystrophy;Pediatric;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE We propose to decipher the fundamental physiological function(s) of the RNA-binding protein, Fragile X-related protein 1 (FXR1), in cardiac and skeletal muscle and the role it plays in the progression of human myopathies. We discovered a direct connection between FXR1 expression levels and muscle dysfunction, and that FXR1 interacts with and regulates mRNAs that encode proteins essential for excitation-contraction coupling, and utrophin, a protein that can functionally substitute for the loss of dystrophin in Duchenne Muscular Dystrophy. This work is predicted to uncover novel insights into RNA-based regulation of striated muscle function, as well as a unique RNA-based therapeutic approach to improve muscle function in multiple diseases, including Duchenne Muscular Dystrophy.

PI_NAMEs: GREGORIO, CAROL C (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Affect;Animal Model;Animal Muscular Dystrophy;Architecture;Area;Attenuated;autism spectrum disorder;Binding;Biology;Canis familiaris;Cardiac;Cell model;Complex;Coupling;Data;Defect;Dilated Cardiomyopathy;Disease;Disease Progression;Duchenne cardiomyopathy;Duchenne muscular dystrophy;Dystrophin;experimental study;Facioscapulohumeral Muscular Dystrophy;Family;Family suidae;FMR1 gene;Fragile X Syndrome;Functional disorder;functional improvement;FXR1 gene;Gene Expression Regulation;gene therapy;Genetic Transcription;Goals;Health;Human;human model;human tissue;improved;in vivo;Inherited;insight;interdisciplinary approach;Investigation;Knock-out;knockout animal;Knockout Mice;Laboratories;Life;Link;Mental disability;Messenger RNA;Metabolism;Modeling;Molecular;mouse model;mRNA Expression;mRNA Stability;mRNA Translation;Multiminicore disease;Mus;Muscle;Muscle Cells;Muscle Contraction;Muscle Development;Muscle function;Muscle relaxation phase;muscular dystrophy mouse model;muscular structure;Myocardium;Myopathy;Myosin Regulatory Light Chains;Myotonic Dystrophy;novel;novel therapeutics;Pathogenesis;Pathology;Perinatal mortality demographics;Phosphorylation;Physiological;Play;Post-Transcriptional Regulation;posttranscriptional;prevent;Process;Property;protein expression;Proteins;Proteome;Rattus;Regulation;Relaxation;Research;response;RNA;RNA-Binding Proteins;Rodent Model;Role;single molecule;skeletal;Skeletal Muscle;Striated Muscles;Structure;Testing;Therapeutic;therapeutic RNA;Tissue Model;Tissues;tool;transcriptome;Utrophin;Work

PROJECT_TITLE: Deciphering the roles of FXR1 in health and myopathy


PHR: CORE 009 – GENOMIC SCIENCES SHARED RESOURCE PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Genomic Sciences Shared Resource.

PI_NAMEs: MALLAL, SIMON ALEXANDER (contact)

PROJECT_TERMS: Automation;biobank;Bioinformatics;Biological;Biological Assay;Cancer Center;Cancer Center Support Grant;Chromium;Classification;Communities;computerized data processing;cost;Data;Data Analyses;data integrity;data management;data quality;design;DNA;DNA sequencing;Dryness;Effectiveness;Ensure;Experimental Designs;experimental study;flexibility;Formalin;Gene Expression;Genome;genome sciences;Genomic approach;genomic data;Genomics;Genotype;Goals;Improve Access;improved;Individual;Informatics;innovation;Laboratories;Libraries;Manuals;medical schools;member;Mentors;Mentorship;Methods;Mission;Modernization;nanopore;NCI Center for Cancer Research;new technology;next generation sequencing;novel strategies;Nucleic Acids;Paraffin Embedding;Performance;Phase;Play;Preparation;Process;programs;Quality Control;Reproducibility;Reproducibility of Results;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;responsible research conduct;RNA;Role;sample collection;Sampling;Science;Services;single cell sequencing;single cell technology;Somatic Mutation;Students;Technology;Tennessee;Time;Tissue Embedding;tool;Training;transcriptome;transcriptome sequencing;Translating;Universities;Variant;Vision;Visualization;whole genome;Work

PROJECT_TITLE: Genomic Sciences Shared Resource


PHR: CORE 010 – IMMUNOPHENOTYPING SHARED RESOURCE PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Immunophenotyping Shared Resource.

PI_NAMEs: RATHMELL, JEFFREY C. (contact)

PROJECT_TERMS: anti-cancer research;Antibodies;Antibody Formation;Antigen-Antibody Complex;B-cell receptor repertoire sequencing;Basic Science;Biological Assay;Bone Marrow;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Patient;cancer therapy;Cell Therapy;Cells;Cellular biology;Cellular Immunity;chemotherapy;chimeric antigen receptor T cells;Clinical;Clinical Investigator;Clinical Management;clinical phenotype;Clinical Sciences;Clinical Trials;Collaborations;Combination immunotherapy;Consultations;cost effective;CTLA4 gene;Cytometry;Data;deep sequencing;design;Dissociation;Evaluation;experience;Experimental Designs;Explosion;Faculty;Flow Cytometry;Flow Cytometry Shared Resource;Future;genome sciences;Genomics;Goals;host neoplasm interaction;Human;Immune;Immune system;Immunofluorescence Immunologic;Immunologic Surveillance;Immunologics;Immunology;Immunology procedure;Immunooncology;Immunophenotyping;Intervention;Investigation;Knowledge;Laboratories;laboratory manuals;Malignant Neoplasms;Measures;meetings;member;Mission;Molecular Target;Mus;NCI Center for Cancer Research;neoantigens;new technology;next generation sequencing;novel;Oncology;operation;Pathology;patient biomarkers;Patient Selection;Patients;PD-1/PD-L1;peripheral blood;Phenotype;Population Sciences;pre-clinical;Pre-Clinical Model;preclinical trial;Process;programs;Publications;Quality Control;Research;Research Design;Research Personnel;Research Project Grants;Resistance;Resource Sharing;response;sample collection;Sampling;Services;single-cell RNA sequencing;Solid Neoplasm;Strategic Planning;success;targeted agent;Technology;Toxic effect;Translational Research;treatment response;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: Immunophenotyping Shared Resource


NIH_SPENDING_CATS: Cancer;Genetics

PHR: CORE 011 – SURVEY AND BIOSPECIMEN SHARED RESOURCE PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Survey and Biospecimen Shared Resource.

PI_NAMEs: CAI, QIUYIN  (contact)

PROJECT_TERMS: Achievement;Adverse event;anti-cancer research;biobank;Bioinformatics;Biological;Biological Assay;Biological Markers;Biostatistics Shared Resource;Blood;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer epidemiology;Case/Control Studies;Clinical;Clinical Investigator;Clinics and Hospitals;Collection;Communities;Computer Assisted;Consultations;cost;cost efficient;Data;Data Collection;Data Science;deep sequencing;design;Diet;DNA;Doctor of Philosophy;doctoral student;Effectiveness;Ensure;Environmental Exposure;Epidemiologist;Epidemiology;epidemiology study;experience;Faculty;Family;Feces;Genetic;Genetic Markers;genome sciences;Genotype;Goals;Health;Immunohistochemistry;improved;Individual;Industry Standard;Interviewer;Investments;Journals;Laboratories;Malignant Neoplasms;Manuscripts;Medical Records;medical schools;member;Mentorship;Metagenomics;metatranscriptomics;Methods;microbiome research;Mission;Molecular;Molecular Epidemiology;molecular marker;Monitor;nano-string;Nature;NCI Center for Cancer Research;new technology;next generation;Oral cavity;Outcome Study;Participant;participant enrollment;Patient Recruitments;Peer Review;Pharmaceutical Preparations;Population;population based;Population Research;Population Sciences;Population Study;Postdoctoral Fellow;Prevention;Procedures;programs;Prospective cohort;Prospective, cohort study;Protocols documentation;Publications;Publishing;Quality Control;Quality of life;randomized trial;Recording of previous events;recruit;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;responsible research conduct;Retrieval;RNA;Saliva;sample collection;Sampling;service utilization;Services;Stains;Students;Surveys;Symptoms;System;Telephone Interviews;Tennessee;Time;Tissues;Training;translational study;United States;Universities;Urine;Variant;Work

PROJECT_TITLE: Survey and Biospecimen Shared Resource


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: The goal of our research is understanding why acute kidney injury dramatically increases mortality in patients who develop sepsis, a dysregulated host response to infection resulting in organ failure. In particular, we are trying to identify how the kidney-derived protein Tamm-Horsfall Protein protects the body from mortality in sepsis. We believe that Tamm-Horsfall Protein does this by regulating the macrophage response in sepsis.

PI_NAMEs: LAFAVERS, KAICE  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Animal Model;Anti-Inflammatory Agents;Area;Bioinformatics;Biological Response Modifiers;Biology;Breeding;Cardiovascular Diseases;cardiovascular infection;career;career development;cecal ligation puncture;Chronic Kidney Failure;Circulation;cohort;Communication;Constitution;Critical Care;Critical Illness;cytokine;Data;Death Rate;Debility;design;Disease;Doctor of Philosophy;Electrolytes;experimental study;Faculty;Failure;Foundations;Functional disorder;Genetic;Genetic Models;Goals;Grant;Hospitalization;Human;human model;Image;Immune response;Immune system;Immune System Diseases;immunoregulation;improved;In Vitro;in vivo;Incidence;individualized medicine;Infection;Inflammatory;Injury;Injury to Kidney;Innate Immune System;Interleukin-15;Investments;Kidney;kidney preservation;Knock-out;Knockout Mice;Knowledge;Knowledge acquisition;Life;Macrophage;Macrophage Activation;Manuscripts;Mediating;Mentors;Mentorship;model development;Modeling;Molecular;Mononuclear;Morbidity - disease rate;mortality;mortality risk;mouse model;Mus;novel;Organ;Organ failure;organ injury;Outcome;Oxidative Stress;Pathogenesis;Patient-Focused Outcomes;Patients;Phagocytes;Phagocytosis;Play;Positioning Attribute;post-doctoral training;Production;programs;protective effect;Protein Deficiency;protein purification;Proteins;Publishing;Renal function;Research;Research Personnel;response;Risk;Role;Science;Sepsis;septic;Septic Shock;Serum;Severities;Signal Transduction;skill acquisition;Technical Expertise;Testing;Therapeutic;Therapeutic Uses;tool;Training;UMOD gene;Urine;Work;Writing

PROJECT_TITLE: The protective role of kidney-derived Tamm Horsfall protein (Uromodulin) in sepsis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research

PHR: CORE 012 – TRANSLATIONAL PATHOLOGY SHARED RESOURCE PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Translational Pathology Shared Resource.

PI_NAMEs: GIBSON-CORLEY, KATHERINE NICOLE (contact)

PROJECT_TERMS: Academic Medical Centers;Animal Experimentation;Animal Model;animal tissue;Animals;anti-cancer research;Antibodies;Biological;Cancer Center;Cancer Center Support Grant;Cells;Clinical;Clinical Pathology;Communities;Comparative Pathology;Computer software;Consultations;Cooperative Human Tissue Network;design;Diagnostic Services;digital;digital imaging;Effectiveness;Ensure;Equipment;Experimental Designs;Fluorescence;Frozen Sections;Funding;Histologic;histological stains;Histology;Histopathology;Human;human model;Human Pathology;Human Resources;human tissue;Image Analysis;imaging capabilities;imaging system;Immunofluorescence Immunologic;Immunohistochemistry;Individual;Institutional Review Boards;instrumentation;Investigation;laser capture microdissection;Malignant Neoplasms;medical schools;member;Mentors;Methods;Modernization;mouse model;NCI Center for Cancer Research;Operating Rooms;Paraffin;Pathologist;Pathology;Performance;Phenotype;Population;pre-clinical;Preparation;Procedures;programs;Protocols documentation;Reproducibility;Research;Research Personnel;research study;Resource Sharing;Resources;robotic system;Scanning;Services;Slide;Specimen;Stains;Students;Technology;Tennessee;tissue biomarkers;Tissue Microarray;Tissue Model;tissue preparation;tissue processing;tissue resource;Tissue Stains;Tissues;Training;Universities;Veterinary Pathology

PROJECT_TITLE: Translational Pathology Shared Resource


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Vector-Borne Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE  Bunyaviruses are a large, diverse group of vector-borne viruses with the capacity to cause neurological disease with morbidity and mortality. A major limitation in our basic scientific understanding of bunyavirus neuropathogenesis stems from the fact that key target cells in the brain are not fully defined, therefore the effect of infection on target cells is unknown, and viral determinants that contribute to neurological disease have not been delineated. Here, we will undertake a comparative analysis of the basic neuropathogenesis of 3 prototype emerging bunyaviruses: La Crosse, Oropouche, and Rift valley fever viruses.

PI_NAMEs: HARTMAN, AMY L (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Affect;Africa;Animals;antagonist;Anti-viral Response;Binding;Biological Models;Brain;Bunyavirales;Bunyavirus Infections;Cell Death;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Childhood;climate change;comparative;Data;Dependence;Disease;Disease Outbreaks;Encephalitis;Epidemic;Family;Fever;Gene Modified;Genome;Genomic Segment;Geographic Locations;global health;Goals;Health;Human;human pathogen;Immune;Immune response;In Vitro;Individual;induced pluripotent stem cell;Infection;innate immune pathways;Innate Immune Response;Insect Vectors;Integration Host Factors;interdisciplinary approach;Knowledge;La Crosse virus;LDL-Receptor Related Protein 1;LDL-Receptor Related Proteins;Ligands;loss of function;Mediating;Medical;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Mus;mutant;National Institute of Allergy and Infectious Disease;nerve stem cell;Nervous System Disorder;Neurobiology;neuroinflammation;Neurons;Neuropathogenesis;neuropathology;neurovirulence;North America;novel;Oropouche virus;Orthobunyavirus;pandemic preparedness;pathogen;Pathogenesis;Pathway interactions;Periodicals;Productivity;protein function;Proteins;prototype;Publishing;Research;response;Rift Valley fever virus;Rodent;Role;Slice;South America;stem;transcriptomics;Tropism;United States;Universities;vector-borne;Viral;Viral Encephalitis;Viral Hemorrhagic Fevers;Viral Nonstructural Proteins;Virulent;Virus;Virus Diseases;Washington;Work

PROJECT_TITLE: Mechanisms of Neuronal Infection by Prototype Emerging Bunyaviruses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VDT-Q(01)]


PHR: PROJECT 001 – GENOME MAINTENANCE RESEARCH PROGRAM PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Genome Maintenance Research Program.

PI_NAMEs: CORTEZ, DAVID K (contact)

PROJECT_TERMS: Adopted;Adult;Affect;Antimetabolites;Antimitotic Agents;Area;Base Pairing;Basic Science;bench to bedside;Biochemistry;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Etiology;Cancer Patient;cancer therapy;cancer type;Carcinogen Metabolism;Catchment Area;Cell Cycle;Cell division;Cell Physiology;Cellular biology;chemotherapy;Chromatin;Chromosome abnormality;Chromosome Segregation;Clinical;Clinical Trials;Collaborations;collaborative environment;community center;Data;design;Development;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair;DNA Sequence Alteration;Doctor of Philosophy;Drug Targeting;Drug usage;empowerment;Ensure;Environment;Epigenetic Process;epigenome;Experimental Designs;Faculty;Fostering;Foundations;Funding;Gene Expression;Gene Expression Profile;Genetic;Genetic Diseases;Genome;genome integrity;Genomic Instability;Genomics;Goals;Grant;Heart;Immune Evasion;Immune system;improved;Individual;Knowledge;Laboratories;Leadership;Life;Link;loss of function mutation;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;member;Mentors;Methods;Mission;model organism;Mutagenesis;Mutation;NCI Center for Cancer Research;NCI-Designated Cancer Center;Neoplasm Metastasis;new technology;next generation;Normal Cell;novel;novel therapeutics;Outcome;Paper;Pathway interactions;Peer Review;Pilot Projects;Process;Program Research Project Grants;programs;Proliferating;protein function;Proteomics;Publications;Publishing;Radiation;recruit;Regulatory Pathway;repaired;Reproducibility;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;response;Schools;Science;Scientist;self-renewal;Specialized Program of Research Excellence;structural biology;Talents;targeted treatment;Technology;Therapeutic;Therapeutic Intervention;Training;Translating;Translations;treatment and outcome;Tumor Suppressor Proteins;tumorigenesis;United States National Institutes of Health;Work

PROJECT_TITLE: Genome Maintenance Research Program


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: PROJECT 002 – SIGNAL TRANSDUCTION AND CHEMICAL BIOLOGY RESEARCH PROGRAM PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Signal Transduction and Chemical Biology Research Program.

PI_NAMEs: CHEN, JIN  (contact)

PROJECT_TERMS: ABCB1 gene;Acceleration;Affect;Affinity;Androgen Receptor;anti-cancer research;Apoptotic;Basic Science;bench to bedside;Biological Availability;Biology;Biomedical Engineering;cancer cell;Cancer Center;Cancer Center Support Grant;cancer initiation;Cancer Intervention;Catchment Area;Cell Cycle;Cell Cycle Regulation;Cell Differentiation process;Cells;Cellular biology;Chemicals;Chemoresistance;Chimera organism;Clinic;Clinical;Clinical Investigator;Clinical Trials;Collaborations;Communication;computerized tools;cost;CRISPR/Cas technology;Cytometry;Dependence;design;Development;Doctor of Philosophy;drug discovery;Educational workshop;Effectiveness;EGF gene;Ensure;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Erinaceidae;Faculty;Fostering;Funding;Future;Gene Expression;genome editing;Genus Capra;Germ Lines;Goals;Heterogeneity;Human;Image Cytometry;industry partner;inhibitor;instrumentation;Investigation;Knock-in;Leadership;Light;Malignant Neoplasms;meetings;member;Mentors;Mentorship;Methods;Microscopy;Mission;Modernization;multi drug transporter;Mus;Mutation;NCI-Designated Cancer Center;new technology;new therapeutic target;novel;novel therapeutics;Pathway interactions;Patients;Peer Review;Pharmaceutical Preparations;Physics;Play;population based;Population Programs;Program Research Project Grants;programs;Proliferating;Publications;Recording of previous events;Reproducibility;Research;Research Personnel;resistance mechanism;Resource Sharing;response;Role;Schools;Science;Scientist;SHH gene;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule;stem cell proliferation;stem cells;Structural Models;Students;superresolution microscopy;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Training;Translating;Translations;tumor;Tumor Cell Biology;tumor progression;tumorigenesis;Work

PROJECT_TITLE: Cancer Cell Biology Research Program


PHR: PROJECT 003 – HOST-TUMOR INTERACTIONS RESEARCH PROGRAM PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Host-Tumor Interactions Research Program.

PROJECT_TERMS: Acceleration;Address;anti-tumor immune response;Area;Basic Science;Binding;Biochemical;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer imaging;cancer therapy;Catchment Area;Cell Communication;Cells;Characteristics;Clinical;clinical translation;Collaborations;Colorectal Cancer;Communities;Complex;Computer Models;computerized tools;Dedications;Development;Discipline;Education;Educational Status;Educational workshop;Evolution;Funding;Goals;Grant;host neoplasm interaction;Image;imaging agent;imaging approach;Imaging Device;Immune;Immune response;Immune system;Immunology;Immunooncology;Immunotherapy;in vivo imaging;Individual;innovation;Interdisciplinary Study;Interruption;Invaded;Investigation;Knowledge;knowledge integration;Leadership;learning community;Light;lung development;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant Neoplasms;mathematical model;member;Metabolic;Modeling;Molecular;Molecular Probes;multidisciplinary;Mutation;Nature;NCI-Designated Cancer Center;Neoplasm Metastasis;neoplastic cell;next generation;non-invasive imaging;novel;novel therapeutic intervention;Nutrient availability;Organism;Peer Review;Play;Population;Program Research Project Grants;programs;Publications;Research;Research Personnel;response;Role;Schools;Science;Scientist;Seminal;single cell analysis;small cell lung carcinoma;Specialized Program of Research Excellence;Subgroup;symposium;Technology;Tissues;Training;Translating;Translational Research;translational scientist;treatment response;tumor;Tumor Biology;Tumor Escape;tumor growth;tumor immunology;tumor initiation;tumor metabolism;tumor microenvironment;tumor progression;Tumor Promotion;tumor-immune system interactions;Whole Organism


NIH_SPENDING_CATS: Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Women's Health Research

PHR: PROJECT 004 – BREAST CANCER RESEARCH PROGRAM PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Breast Cancer Research Program.

PI_NAMEs: BALKO, JUSTIN M (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Back;Basic Science;bench to bedside;Bioinformatics;Biotechnology;Breast;Breast Cancer therapy;Breast Epithelial Cells;breast pathology;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Research Project;cancer subtypes;care delivery;Caring;Catchment Area;cell free DNA;Cellular biology;Clinical;clinical investigation;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Design;Collaborations;Data;Development;DNA Repository;Doctor of Philosophy;Drug resistance;Epidemiology;Faculty;Fostering;Funding;Genetic;genomic profiling;Genomics;Goals;Guidelines;health disparity;Healthcare;Immunotherapy;improved;Incubators;Industry;innovation;Institution;interest;International;Intervention;Intervention Trial;Laboratories;Life Style;liquid biopsy;Malignant Breast Neoplasm;Mammary Neoplasms;Medical Oncology;Medicine;meetings;member;Mentors;Methods;Molecular Biology;Molecular Epidemiology;Monitor;mortality disparity;multidisciplinary;NCI-Designated Cancer Center;next generation;novel;Obesity;Outcome;Patients;Peer Review;Pilot Projects;Play;population based;Population Research;predictive marker;professor;Program Research Project Grants;programs;Protocols documentation;Publications;Quality of life;Radiation Oncology;recruit;Reduce health disparities;Reporting;Research;Research Personnel;Role;Running;Safety;Schools;Series;Signal Transduction;Specialized Program of Research Excellence;Surgical Oncology;Technology;Tissue Banks;Toxic effect;training opportunity;Translating;Translational Research;Translations;treatment trial;Universities

PROJECT_TITLE: Breast Cancer Research Program


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Esophageal Cancer;Infectious Diseases;Prevention;Rare Diseases;Stomach Cancer

PHR: PROJECT 005 – GASTROINTESTINAL CANCER RESEARCH PROGRAM PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Gastrointestinal Cancer Research Program.

PI_NAMEs: ENG, CATHY  (contact)

PROJECT_TERMS: Academic Medical Centers;Adopted;advanced disease;aging population;anti-cancer research;Area;Basic Science;Berlin;Biological Markers;Biology;Body System;Cancer Center;Cancer Center Support Grant;cancer genetics;cancer prevention;Cancer Research Project;carcinogenesis;career;career development;Catchment Area;Cessation of life;Cetuximab;Clinical;clinical application;clinical care;Clinical Research;Clinical Treatment;Clinical Trials;Collaborations;Colorectal Cancer;community center;Data;Development;Diagnosis;Diagnostic Imaging;Disease;Doctor of Philosophy;Dysplasia;Education;empowerment;Epidemiology;Epidermal Growth Factor Receptor;Etiology;Extramural Activities;Faculty;Fc Receptor;Fostering;Foundations;Funding;Gastric Metaplasia;gastroesophageal cancer;Gastrointestinal Neoplasms;Helicobacter pylori;Helicobacter pylori induced carcinogenesis;Hepatitis C;Human Papillomavirus;imaging modality;Immunity;improved;Incidence;Infection;Inflammation;Investigation;Jordan;Knowledge;Leadership;Learning;Malignant neoplasm of anus;Malignant neoplasm of esophagus;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant stomach neoplasm;member;Mentors;metastatic colorectal;method development;Methods;microbiome;microbiome research;Modality;mortality;NCI Center for Cancer Research;neuroendocrine cancer;Neuroendocrine Carcinoma;new technology;next generation;nonalcoholic steatohepatitis;novel;novel diagnostics;novel strategies;Pancreas;panitumumab;Pathogenesis;Patient Care;Patient-Focused Outcomes;Patients;Peer Review;Pharmacology;Postdoctoral Fellow;pre-clinical;prevent;Prevention;Prevention strategy;Primary carcinoma of the liver cells;Process;Prognosis;Program Research Project Grants;programs;Publications;Receptor Signaling;recruit;Research;Research Personnel;Resistance;resistance mechanism;Resource Sharing;response;Risk Factors;Role;Schools;Scientist;Series;Small Intestines;Source;Students;success;synergism;Talents;targeted treatment;Technology;Therapeutic;therapy resistant;Training;Translating;Translational Research;Translations;tumor microenvironment;tumor progression;United States;Work


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Small cell lung cancer (SCLC) is initially sensitive to chemotherapy. However, relapse is nearly inevitable, at which point SCLC becomes resistant to many similar therapies. We have grown tumors from patients before and after relapse directly in mice, and will use these to learn how SCLC becomes resistant after relapse.

PI_NAMEs: DRAPKIN, BENJAMIN J (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;arm;Biological Assay;Biological Markers;Biological Models;biomarker driven;Biopsy;Biopsy Specimen;Cancer Patient;chemotherapy;Clinical;Clinical Sensitivity;Clinical Trials;co-clinical trial;Collection;comparative;cytokine;Diagnosis;Disease;DNA Damage;drug sensitivity;effusion;epigenetic silencing;established cell line;Etoposide;experience;experimental study;Formalin;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic signature;Guidelines;Heterogeneity;Immune response;Immune system;Immunocompromised Host;In Situ Hybridization;Individual;individual patient;Inter-tumoral heterogeneity;Interferons;Investigational Therapies;knockout gene;Learning;Malignant Neoplasms;Mediating;Modeling;Molecular;mouse model;Mus;Mutation;National Comprehensive Cancer Network;Nature;Neoplasm Circulating Cells;NOR Mouse;novel;Outcome;Paraffin Embedding;pathogen;Pathway interactions;patient derived xenograft model;patient population;patient response;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phase I/II Trial;Platinum;Population;Prognosis;Property;Recording of previous events;Regimen;Relapse;Resistance;resistance mechanism;response;RNA;Role;Sampling;Signal Transduction;small cell lung carcinoma;Solid Neoplasm;Specimen;Stimulator of Interferon Genes;targeted treatment;temozolomide;Testing;Time;Tissue Sample;Topotecan;Translational Research;treatment response;trial design;tumor;Validation;Variant;Xenograft procedure

PROJECT_TITLE: Dissecting and overcoming cross-resistance to DNA damaging agents in SCLC

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Immunotherapy;Patient Safety;Precision Medicine;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: PROJECT 006 – TRANSLATIONAL RESEARCH AND INTERVENTIONAL ONCOLOGY RESEARCH PROGRAM PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Translational Research and Interventional Oncology Research Program.

PI_NAMEs: JOHNSON, DOUGLAS B (contact)

PROJECT_TERMS: Acceleration;Address;Adverse event;Affect;Allogenic;Antineoplastic Agents;bench to bedside;cancer care;Cancer Center;Cancer Center Support Grant;cancer therapy;Catchment Area;Cell Therapy;Clinic;Clinical;Clinical Cancer Center;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Communities;Continuity of Patient Care;Correlative Study;Development;Discipline;Disease;Disparate;Doctor of Philosophy;Effector Cell;Evolution;experience;Fertilization;Funding;Future;Goals;graft vs host disease;Grant;Growth;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Immune;Immune checkpoint inhibitor;Immune system;Immunooncology;Immunotherapy;implementation facilitation;improved;Industry;industry partner;innovation;insight;Institution;International;Intervention;Investigation;Laboratories;Laboratory Scientists;Lead;Leadership;Malignant Neoplasms;member;Mission;Molecular;Multi-Institutional Clinical Trial;multidisciplinary;NCI Center for Cancer Research;NCI-Designated Cancer Center;neoplastic;new therapeutic target;next generation;novel;Oncology;Patient-Focused Outcomes;Patients;Peer Review;Policies;Positioning Attribute;Practice Management;precision medicine;precision oncology;prevent;Productivity;Program Research Project Grants;programs;Publications;Research;Research Personnel;resistance mechanism;Risk;Role;Schools;Science;Scientific Advances and Accomplishments;skills;Solid;Standardization;Stem cell transplant;Structure;Surgical Oncology;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Time;Toxic effect;Translating;translational oncology;Translational Research;translational scientist;treatment response;Work


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention

PHR: PROJECT 007 – CANCER EPIDEMIOLOGY RESEARCH PROGRAM PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Cancer Epidemiology Research Program.

PI_NAMEs: SHU, XIAO-OU  (contact)

PROJECT_TERMS: Academic Medical Centers;Affect;All of Us Research Program;Area;Basic Science;biobank;Biological Markers;biomarker identification;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer epidemiology;Cancer Etiology;cancer genome;cancer health disparity;Cancer Patient;cancer prevention;Cancer Prognosis;cancer risk;Cancer Survivor;career development;Caring;Case/Control Studies;Catchment Area;Clinical Sciences;cohort;Cohort Studies;Collaborations;Communities;Country;Data;design;Development;DNA;DNA Databases;Doctor of Philosophy;Early Diagnosis;Educational workshop;Electronic Health Record;Enrollment;Environment;Environmental Risk Factor;Epidemiology;epidemiology study;Etiology;experience;follow-up;Fostering;Funding;Future;Genetic;genome wide association study;Genomic DNA;Goals;Grant;Group Meetings;Growth;Guidelines;health determinants;improved;Incidence;International;Intervention Trial;Joints;Journals;Knowledge;Laboratories;Lead;Leadership;Life Style;lifestyle factors;Link;male health;Malignant Neoplasms;Medical;medical schools;member;Methods;Mission;Modification;Morbidity - disease rate;mortality;NCI-Designated Cancer Center;next generation;nutrition;Participant;Patients;Peer Review;Pharmacogenomics;Play;Population;population based;Population Research;Populations at Risk;Positioning Attribute;Prevention strategy;Productivity;Program Research Project Grants;programs;Publications;Recommendation;recruit;Research;Research Methodology;Research Personnel;research study;Research Support;Resources;Risk;Risk Assessment;Role;Sampling;Schools;Scientist;success;Technology;Testing;Training;Training Programs;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Women's Health;working group

PROJECT_TITLE: Cancer Epidemiology Research Program


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative As speech unfolds through time, listeners predict the importance and timing of incoming information. Several language disorders are associated with impairments in timing and attention mechanisms, yet the relevance of these mechanisms to language comprehension is not well defined. This project investigates the role of temporal prediction and attention in language processing for healthy individuals and will shape the development of effective forms of therapy for these disorders.

PI_NAMEs: BEIER, ELEONORA JUDITH (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Address;Adult;Apple;Attention;Auditory Perception;base;Behavioral;Brain;Cognition;Cognitive;cognitive neuroscience;cognitive skill;Collection;Comprehension;Computer Models;Cues;Data Collection;Detection;Development;directed attention;Disease;Eating;Electrophysiology (science);Environment;Event;Event-Related Potentials;Experimental Designs;experimental study;Fellowship;Future;Germany;Goals;Impairment;improved;Individual;Individual Differences;interdisciplinary approach;Language;language comprehension;Language Disorders;language processing;Learning;Linguistics;Literature;Measures;Mediating;Memory;method development;Methodology;Methods;Mind;Modeling;National Institute of Mental Health;neural;Neurocognitive;Neurosciences;Neurosciences Research;Participant;Periodicals;Periodicity;Persons;Play;Psycholinguistics;Research;response;Role;semantic processing;Semantics;Sensory;Shapes;Signal Transduction;skills;Source;Speech;Speech Disorders;Stress;Structure;Testing;Theoretical model;theories;Time;Training;Training Programs;Visit;Visual Perception

PROJECT_TITLE: The role of temporal prediction in guiding attention through time during language comprehension.


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Obesity;Patient Safety;Prevention;Tobacco;Tobacco Smoke and Health

PHR: PROJECT 008 – CANCER HEALTH OUTCOMES AND CONTROL RESEARCH PROGRAM PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Cancer Health Outcomes and Control Research Program.

PI_NAMEs: BAROCAS, DANIEL A (contact)

PROJECT_TERMS: Antineoplastic Agents;Area;Behavior;behavior test;Biological Markers;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer health disparity;cancer prevention;cancer therapy;care delivery;Catchment Area;Categories;Clinical;Collaborations;Communities;community center;comparative effectiveness;comparative treatment;Complement;Continuity of Patient Care;cost;Coupled;Decision Making;Disparity;Doctor of Philosophy;Early Diagnosis;Equilibrium;Fostering;Funding;Future;Health;Health behavior;Health Services Accessibility;Healthcare;High Prevalence;HPV vaccine acceptance;Human Papilloma Virus Vaccine;Imaging Techniques;implementation science;Improve Access;improved;improved outcome;Incidence;Individual;innovation;Insurance;interest;Intervention;Laboratories;Leadership;lung cancer screening;Malignant Neoplasms;member;Mentorship;Mission;mortality;NCI-Designated Cancer Center;Obesity;obesity prevention;Outcome;outreach;patient oriented;patient safety;Patient-Focused Outcomes;Peer Review;Policies;Population;population based;Populations at Risk;Positioning Attribute;prevent;Prevention;Program Research Project Grants;programs;Public Health;Publications;Research;Research Personnel;Risk;Schools;Science;screening;skills;smoking cessation;Therapeutic Clinical Trial;therapy development;Tobacco use;Tobacco Use Cessation;Toxic effect;Training;treatment strategy


ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Type II topoisomerases are molecular machines that untangle DNA and serve as targets of frontline anticancer drugs. The present proposal seeks to better understand and improve upon how anti-topoisomerase agents work; we will also determine how mutant topoisomerase variants, which are found in cancer cells, may contribute to genetic damage and chromosome instability.

PI_NAMEs: BERGER, JAMES M. (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Amino Acid Sequence;Antineoplastic Agents;Biochemical;Biology;Cancer Biology;cancer cell;Cancer Etiology;cancer therapy;Cells;Chemicals;Chromatin;Chromosomal Instability;Chromosomes;Citric Acid Cycle;DNA;DNA Damage;DNA Topoisomerases;drug action;Drug Targeting;Enzymes;Eukaryotic DNA Topoisomerases II;Genetic;genetic information;genome integrity;Goals;Human Chromosomes;improved;innovation;Malignant Neoplasms;Methodology;Molecular Machines;mutant;Outcome;Play;Proteins;Research;Role;Site;Specificity;Superhelical DNA;Topoisomerase;Topoisomerase II;Variant;Work

PROJECT_TITLE: Understanding and exploiting DNA topoisomerases in cancer biology


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: Jupiter

ORG_NAME: MAX PLANCK FLORIDA CORPORATION

ORG_STATE: FL

PHR: Altered neurotransmitter and neuromodulator (NM) signaling is a key feature of virtually all human neurological and psychiatric disorders, including Parkinson’s disease, schizophrenia, depression, and addiction. We will engineer, validate and disseminate optimized genetically encoded sensors for visualizing neuronal communication with enhanced depth and resolution using advanced microscopy techniques. Combined with optogenetics and calcium/voltage imaging, applications of these tools will reveal the full richness of neuromodulatory signaling to greatly extend, and potentially transform, our understanding of how neurochemical inputs influence cell and circuit function in health and disease.

PI_NAMEs: TIAN, LIN  (contact);VONZASTROW, MARK E

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TITLE: Multiplex interrogation of neuromodulatory signaling in behaving animals with enhanced depth and resolution


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PHR: CCSG COMPONENT 001 – LEADERSHIP, PLANNING AND EVALUATION PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Leadership, Planning and Evaluation Core.

PI_NAMEs: PARK, BEN HO (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;Area;authority;Basic Science;Biomedical Research;Breast;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer Patient;career;career development;Caring;Catchment Area;Cessation of life;Clinical;Clinical Cancer Center;Clinical Research;Cohort Studies;Collaborations;Communities;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;Decision Making;Development;Disease;Education;Ensure;Environment;Essential worker;Evaluation;Evaluation Research;evidence base;experience;Extramural Activities;Feedback;Funding;Goals;Grant;Individual;innovation;insight;Institution;Intervention;Investments;Lead;Leadership;Malignant Neoplasms;medical schools;meetings;member;Mission;National Cancer Program;operation;outreach;Patient Care;Patient-Centered Care;Patients;Performance;Philanthropic Fund;Policies;Population Research;Positioning Attribute;Prevention;Process;process evaluation;Productivity;Program Development;programs;Recommendation;recruit;Reproducibility;Reproduction spores;Research;Research Personnel;Resource Sharing;Resources;Science;Scientific Advances and Accomplishments;Scientist;Strategic Planning;Structure;System;Talents;Tennessee;Time;Training and Education;Translating;Translations;tumor;Universities;Vision;Work;working group

PROJECT_TITLE: Leadership Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PHR: CCSG COMPONENT 002 – DEVELOPMENTAL FUNDS PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Development Funds Core.

PROJECT_TERMS: Advanced Malignant Neoplasm;Adverse reactions;anti-cancer research;Antibody Formation;Area;Award;Budgets;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer epidemiology;cancer genetics;cancer health disparity;cancer therapy;career;Catchment Area;Categories;Cells;Clinical;Clinical Cancer Center;Clinical Investigator;Clinical Research;Clinical Trials;Communities;cost;Creativeness;Data;Dedications;design;Development;drug development;Early Diagnosis;Ensure;Epigenetic Process;Evaluation;Evolution;Experimental Designs;Extramural Activities;Faculty;Faculty Recruitment;Fostering;Funding;Genitourinary system;Genomics;Goals;Grant;health disparity;Hematologic Neoplasms;Immune;Immunofluorescence Immunologic;immunological status;Immunology;Immunooncology;Immunophenotyping;Immunotherapy;Individual;Infrastructure;innovation;Investigation;Investments;Knowledge;Leadership;Life;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Measures;Medical Oncology;member;Mentors;Mentorship;Methods;Mission;Mus;Names;next generation;novel therapeutics;Outcome;Patient Recruitments;Patients;Peer Review;Peer Review Grants;Peripheral;Persons;Pharmacology;Phase;Phenotype;Pilot Projects;Population Research;Positioning Attribute;precision oncology;programs;Publications;Radiation Oncology;recruit;Reproducibility;Research;Research Personnel;Resource Sharing;screening;Services;Source;Special Population;Students;success;Surveys;therapy resistant;Training;Translational Research;Work

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Prevention;Racial and Ethnic Minority Health Research

PHR: CCSG COMPONENT 003 – CLINICAL PROTOCOL AND DATA MANAGEMENT PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Clinical Protocol and Data Management Core.

PI_NAMEs: DAVIS, ELIZABETH J (contact)

PROJECT_TERMS: Acceleration;Adult;Affect;Age;Basic Cancer Research;bench to bedside;Biological Markers;Black Populations;Budgets;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Patient;cancer prevention;cancer risk;Caring;Catchment Area;Cell Therapy;Child;Childhood;Clinical;Clinical Cancer Center;Clinical Data;Clinical Investigator;Clinical Management;Clinical Practice Guideline;Clinical Protocols;Clinical Trials;cohort;Complex;Contracts;Data;data integrity;data management;Detection;Disease;Economically Deprived Population;end of life;Enrollment;Ensure;Faculty;Fostering;Gender;Goals;Good Clinical Practice;Immunotherapy;improved;improved outcome;industry partner;Infrastructure;Institution;International;Intervention Trial;investigator-initiated trial;Latino Population;Literature;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mediation;Minority;Minority Groups;Mission;Modality;Molecular Biology;Molecular Target;Monitor;Nursing Research;operation;organizational structure;participant enrollment;Patient Participation;patient safety;patient subsets;Patients;Population;population health;Population Sciences;Populations at Risk;Prevention;Process;process improvement;Program Development;Protocols documentation;Publishing;quality assurance;Race;Recommendation;Reporting;Research;Research Personnel;Safety;sample collection;Sarcoma;Services;socioeconomic disadvantage;sound;Specimen;Specimen Handling;standard of care;Structure;Supportive care;symposium;System;targeted agent;tool;Toxic effect;Training;translational cancer research;translational scientist;Treatment Protocols;trial design;triple-negative invasive breast carcinoma;Underserved Population;United States National Institutes of Health;Woman;Work;young adult

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Human Genome;Infectious Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE Proposal Title: HIV Genomic Aging Project in Oncology (HIV-GAP) Patients with HIV (PWH) who are diagnosed with cancer have inferior outcomes compared to their tumor site/stage-matched counterparts without HIV. Our preliminary data suggest that PWH and cancer experience advanced biological aging and that this accelerated aging may adversely impact prognosis. We therefore propose a multi-institutional, prospective investigation of the role of genomic biomarkers of aging as risk factors for adverse outcomes in 200 PWH and 200 matched, HIV-uninfected cancer patients, with the goal of identifying biomarkers that can guide tailored clinical management strategies to improve cancer outcomes in PWH.

PI_NAMEs: COGHILL, ANNA  (contact);GILLIS, NANCY

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: Acceleration;Accounting;Address;adverse outcome;Age;age acceleration;age group;age related;Aging;aging biomarker;aging related;AIDS related cancer;anti aging drug;antiretroviral therapy;bead chip;biological age;Biological Aging;biomarker identification;Blood;Blood Cells;Cancer Burden;Cancer Center;cancer complication;cancer diagnosis;Cancer Patient;Cancer Relapse;cancer therapy;Cardiovascular Diseases;Cause of Death;Cessation of life;Chronic Disease;Chronology;Clinical;Clinical Management;cohort;Consent;Data;Development;Diagnosis;Disease;DNA;DNA Methylation;Ensure;epigenetic clock;Epigenetic Process;Evaluation;Evolution;experience;Female;follow-up;functional status;Future;Gait speed;gastrointestinal;Gastrointestinal Neoplasms;Gender;General Population;genomic biomarker;Genomics;Goals;Gynecologic;Gynecologic Oncology;Hematopoiesis;Hematopoietic stem cells;HIV;HIV Seronegativity;human old age (65+);Immune System Diseases;improved;Incidence;Individual;Inferior;Inflammation;Institution;instrumental activity of daily living;Investigation;Knowledge;Life Expectancy;Link;male;Malignant Neoplasms;Measures;men;Modification;Monitor;mortality;mortality risk;Mutation;Neoplasm Metastasis;next generation sequencing;novel;novel strategies;Oncology;Outcome;outcome disparities;Patients;Persons;Prevalence;Process;Prognosis;programs;prospective;Protocols documentation;Race;Recurrent disease;Refractory;Reporting;Risk Factors;Role;sample collection;Sample Size;Sampling;Selection for Treatments;senolytics;Site;Solid Neoplasm;Time;tool;Translating;translational impact;tumor;Tumor Tissue;Vital Status;Work

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Cancer;Patient Safety

PHR: CCSG COMPONENT 004 – PROTOCOL REVIEW AND MONITORING SYSTEM PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Protocol Review and Monitoring System Core.

PI_NAMEs: BALJEVIC, MUHAMED  (contact)

PROJECT_TERMS: Address;Affect;Area;Attention;Biometry;black women;cancer care;Cancer Center;Cancer Center Support Grant;cancer subtypes;Catchment Area;Clinical;Clinical Data;Clinical Research;Clinical Trials;Committee Members;Committee Membership;Communities;community engagement;Community Outreach;Complement;demographics;design;Discipline of obstetrics;Disease;Doctor of Philosophy;Eligibility Determination;Ensure;Environment;Evaluation;experience;Experimental Designs;Extramural Activities;Eye;Faculty;Financial Support;Funding;Goals;Gynecologic Oncology;Gynecology;health disparity;Hematology;Individual;Institution;Institutional Review Boards;Intervention;Intervention Trial;Leadership;life span;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Medicine;meetings;member;Mentors;Methods;Minority Groups;Monitor;Monitoring Clinical Trials;NCI Center for Cancer Research;Nurses;Oncology;Participant;Patient Monitoring;patient safety;Patients;Physicians;Procedures;Process;professor;Protocols documentation;Rare Diseases;Recommendation;Reproducibility;Research;Research Design;Research Personnel;responsible research conduct;Review Committee;Role;Science;Services;sound;Strategic Planning;Students;System;Tissues;translational potential;treatment trial;triple-negative invasive breast carcinoma;Work

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Microbiome

ORG_CITY: EAST LANSING

ORG_DEPT: ZOOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: NARRATIVE Almost all animals form mutualistic associations with bacteria, and these interactions can be integral to human health, but although we are beginning to get a better picture of how microbiomes affect their hosts, the mechanisms by which animal hosts ensure the cooperation of their symbionts are less clear. Using two complementary symbiotic systems, I will identify and dissect how hosts sense cooperation by their symbionts and then influence their symbionts accordingly. This work will elucidate mechanisms underlying symbiosis maintenance that may be common across animal taxa and therefore may give us new ways in which we can understand and modulate microbiomes to benefit human health.

PI_NAMEs: HEATH-HECKMAN, ELIZABETH A. (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Elucidating Molecular Mechanisms Underlying Cooperation in Animal-Bacterial Symbioses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Lung;Lung Cancer;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Vaccine Related;Women's Health Research

PHR: CCSG COMPONENT 005 – COMMUNITY OUTREACH AND ENGAGEMENT PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Community Outreach and Engagement.

PI_NAMEs: WINKFIELD, KAREN MARIE (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Adherence;Adoption;Adult;Advocacy;Alabama;Basic Science;bench to bedside;Breast Cancer Detection;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer health disparity;Cancer Patient;cancer prevention;Caregivers;Caring;Catchment Area;Cervical Cancer Screening;Characteristics;Childhood;Classification;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Colon Carcinoma;colorectal cancer screening;Communities;community center;community engaged approach;community engagement;Community Health Education;Community Outreach;community partners;Comprehensive Cancer Center;Counseling;County;Coupled;Cutaneous Melanoma;Death Rate;design;Development;disparity reduction;Dissemination and Implementation;Doctor of Philosophy;Early Diagnosis;Education;empowerment;ethnic disparity;ethnic diversity;evidence base;evidence based guidelines;Evidence based practice;fundamental research;Genetic Counseling;genetic testing;geographic disparity;Geography;Guidelines;Health;health care settings;health disparity;Health Knowledge Attitudes Practice;Health Policy;Health Services Accessibility;High Prevalence;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;Improve Access;improved;Incidence;Inherited;Kentucky;Leadership;literate;lung cancer screening;Malignant neoplasm of cervix uteri;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant oropharynx neoplasm;minority patient;Mission;Modeling;Molecular;NCI Center for Cancer Research;Obesity;Obesity associated cancer;obesity prevention;obesity treatment;Outcome;outreach;patient navigation;Patients;Personal Satisfaction;Policies;Population;Population Heterogeneity;Population Sciences;Prevention;Prevention Guidelines;programs;racial disparity;racial diversity;recruit;Rectal Cancer;Research;Research Personnel;Research Priority;research study;Rural;rural area;rural patients;screening;Screening for cancer;screening guidelines;Site;smoking cessation;survivorship;System;Technology;Tennessee;Therapeutic;tobacco screening;Tobacco Use Cessation;Translating;tumor;Underrepresented Populations;urban area;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: This proposal seeks to understand how sophisticated forms of learning are implemented in neural circuits. To do this we will apply cutting-edge approaches for measuring activity in neuronal populations, mapping circuitry at high-resolution, and theoretical modeling to an advantageous model system—the weakly electric mormryid fish. The research will produce a detailed computational model, spanning from biophysical to network levels, of how learning arises from synaptic plasticity that is widely distributed across processing layers and cell types.

PI_NAMEs: ABBOTT, LAURENCE F.;SAWTELL, NATHANIEL  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Animals;Artificial Intelligence;Automobile Driving;Axon;Back;Behavioral;Biological;Biological Models;Biophysical Process;Biophysics;Brain;Brain region;cell type;Cerebellum;Complex;Computer Models;computer scientist;Data;Data Set;Detection;Environment;experience;Fishes;Goals;Hippocampus;Human;In Vitro;in vivo;Individual;insight;Knowledge;Learning;Lobe;Machine Learning;Mammals;Maps;Measures;Mediating;Memory;Modeling;Modification;Monitor;Mormyridae;Neocortex;neural;neural circuit;neural correlate;neural network;Neurons;Neurosciences;novel;Output;Phase;Population;predictive modeling;Process;Recurrence;Research;Resolution;Role;Scheme;sensory cortex;sensory input;Shapes;Signal Transduction;Site;skills;Speed;Stimulus;Synapses;Synaptic plasticity;System;Testing;Theoretical model;Time;Work

PROJECT_TITLE: Understanding Multi-Layer Learning in a Biological Circuit


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Working memory, the capacity to temporarily hold multiple pieces of information in mind for manipulation, is central to almost all cognitive abilities. Working memory is involved in many mental disorders, including Alzheimer’s disease, schizophrenia, dementia, bipolar depression, autism, and attention deficit hyperactivity disorder. The major goal of this U19 program is to determine how the brain produces decisions based on working memory, via a coordinated effort by multiple researchers to observe, map, perturb, and model brain circuits with state-of-the-art technologies, which will provide critical clues to potential therapeutic approaches and constitute a major advance in basic science.

PI_NAMEs: BRODY, CARLOS D (contact);FIETE, ILA R.;GOLDMAN, MARK S;PILLOW, JONATHAN WILLIAM;SEUNG, HYUNJUNE SEBASTIAN;TANK, DAVID W;WANG, SAMUEL SHENG-HUNG;WITTEN, ILANA

PROJECT_TERMS: Address;Alzheimer's Disease;Anatomy;Animals;Architecture;Area;Arousal;Attention deficit hyperactivity disorder;autism spectrum disorder;Basic Science;Behavior;Behavioral;Behavioral Paradigm;Biological Assay;Bipolar Depression;Brain;BRAIN initiative;Brain region;Cognitive;cognitive ability;cognitive process;Computer Models;computer studies;Data;Decision Making;Dementia;Development;Electron Microscopy;Electrophysiology (science);Etiology;Exhibits;experimental study;Family;Geometry;Goals;Hippocampus;Hunger;Image;Individual;Joints;Link;Maps;member;Mental disorders;Methods;Modeling;Modernization;Mus;Neocortex;neocortical;neural;neural circuit;neuromechanism;Neurons;Neurosciences;next generation;novel;operation;Performance;Physiological;population based;Positioning Attribute;programs;Research;Research Personnel;Resolution;Rodent;Role;Running;scaffold;Schizophrenia;Series;Short-Term Memory;Side;Silicon;Statistical Methods;Structure;System;Task Performances;Technology;Testing;Therapeutic;Thirst;Time;Transmission Electron Microscopy;Variant;virtual reality;Work

PROJECT_TITLE: Mechanisms of neural circuit dynamics in working memory and decision-making


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: TANK, DAVID W (contact)

PROJECT_TERMS: Anatomy;Appearance;Architecture;Area;Behavior;Brain;BRAIN initiative;Brain region;Code;Corpus striatum structure;Cues;Data;Data Science;Decision Making;Dorsal;Electron Microscopy;entorhinal cortex;Etiology;Excision;Exhibits;experimental study;Foundations;Generations;Geometry;Hippocampus;Lateral;Level of Evidence;Location;Medial;model building;Modeling;Mus;Neocortex;neocortical;network architecture;network models;neural;neural circuit;neural model;neural network architecture;Neuroanatomy;neuroimaging;neuromechanism;Neurons;Optics;Photic Stimulation;Population;Positioning Attribute;Property;Ramp;Recurrence;Resolution;response;Role;scaffold;Short-Term Memory;Source;Structure;Testing;Time;virtual;Work

PROJECT_TITLE: P1: Sources and Mechanisms of Sequential Activity


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE This project will transform our understanding of how, why, and for whom education shapes risk of Alzheimer’s Disease and Related Dementias (AD/ADRD). Using new survey, biological, and MRI data collected from a uniquely valuable ongoing cohort study (The National Longitudinal Study of the High School Class of 1972), we will answer questions about (a) how and why education affects AD/ADRD risk; (b) the extent to which adult socioeconomic attainments mediate those effects; and (c) the extent to which racial and ethnic differences in the quality of and returns to education account for disparities in AD/ADRD risk. Our findings—as well as the data that we will disseminate widely—will inform efforts to use educational interventions to reduce AD/ADRD risk and narrow racial and ethnic disparities in cognitive functioning of future cohorts of older Americans.

PI_NAMEs: GRODSKY, ERIC ;MULLER, CHANDRA L (contact);WARREN, JOHN ROBERT

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Behavioral;Biological;Biological Assay;Biological Markers;Biological Process;Black race;Blood;Blood Vessels;blood-based biomarker;Brain imaging;Budgets;cerebrovascular;Cerebrovascular Disorders;Cognition;Cognitive;cognitive change;cognitive function;cognitive reserve;cognitive testing;cohort;Cohort Studies;college;Communities;Data;Data Analyses;Data Collection;data storage site;design;Disparity;economic outcome;Education;Educational Intervention;Employment;Environment;ethnic difference;ethnic disparity;Ethnic Origin;experience;Family;field study;Free Will;Future;Genetic;Genetic Markers;genomic data;Goals;Health;Heterogeneity;high school;Home;Home visitation;Housing;Impaired cognition;improved;Interview;Knowledge;Laboratories;late life;Latinx;Life;Life Cycle Stages;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;member;middle age;Modeling;Nerve Degeneration;Neurocognitive;neuroimaging;Neurologist;neuropathology;Outcome;Participant;Pathway interactions;Persons;Policies;Population;preventive intervention;prospective;Prospective Studies;Protocols documentation;Race;racial difference;racial disparity;rate of aging;Recontacts;Research;Research Personnel;resilience;Resources;response;Risk;Risk Marker;Role;Sampling;Schools;Scientist;Secure;sex;Shapes;socioeconomics;sociologist;statistics;Surveys;Testing;theories;Time;twelfth grade;Whole Blood

PROJECT_TITLE: Education and Cognitive Functioning in Later Life: The Nation’s High School Class of 1972


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: BRODY, CARLOS D (contact)

PROJECT_TERMS: Affect;Area;Behavior;Behavioral;Brain;BRAIN initiative;Brain region;Calcium;Cells;Code;Cognitive;Data;Data Analyses;Data Science;Data Set;Decision Making;design;Differential Equation;Dimensions;Dorsal;Etiology;experimental study;Foundations;Funding;Generations;Geometry;Goals;Hippocampus;Image;Individual;information organization;insight;Learning;Measures;Memory;Methods;Modeling;Mus;Neocortex;neocortical;network architecture;neural;neural circuit;neural model;Neuroanatomy;neuromechanism;Neurons;new technology;Optics;optogenetics;Physiological;Population;Positioning Attribute;predictive modeling;Prefrontal Cortex;preservation;programs;Property;Psychological reinforcement;Resolution;scaffold;Short-Term Memory;statistical learning;Structure;success;Testing;virtual reality;Work

PROJECT_TITLE: P2: Geometry of Neural Representations and Dynamics


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Cerebrovascular;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Stroke

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Project Narrative: Serotonin based therapeutics in cerebral palsy Cerebral palsy (CP) is a disorder caused by an insult to the developing brain that affects a person's ability to control his or her muscles. Patients often exhibit muscle stiffness, uncontrolled movements, and muscle weakness, but the origin of these symptoms remain poorly understood and treatments are sparse. The aim of this proposal is to evaluate using a serotonergic drug to treat babies at risk for cerebral palsy before their nervous system matures in a dysfunctional way.

PI_NAMEs: QUINLAN, KATHARINA ANN (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Affect;Age;Agonist;Anatomy;Animal Model;antagonist;Appearance;awake;Birth;Brain;Brain Hypoxia-Ischemia;Cell Death;Cell model;Cerebral Palsy;Child;Clinical;Corticospinal Tracts;critical developmental period;critical period;Data;Dependence;Development;Disease;Dose;efficacy evaluation;Electrophysiology (science);Exhibits;FDA approved;Fetus;Functional disorder;H-Reflex;Histologic;Hyperreflexia;hypoxic ischemic injury;improved outcome;In Vitro;in vivo;Infant;Injury;Joints;Knowledge;Ligands;Measurement;Measures;Mediating;Mental Depression;Methods;Methysergide;Modeling;Motor;Motor Activity;motor behavior;motor deficit;motor disorder;Motor Neurons;Movement;Muscle;Muscle Fibers;Muscle Hypertonia;muscle stiffness;Muscle Weakness;neonate;Nervous System;neural;neuromuscular;neurotransmission;Neurotransmitters;Newborn Infant;novel;novel therapeutic intervention;novel therapeutics;Oryctolagus cuniculus;Outcome;patch clamp;Pathology;Patients;Pattern;Perinatal;perinatal injury;Persons;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Physiological;postnatal;Pre-Clinical Model;preclinical evaluation;Pregnancy;prenatal;Prenatal Injuries;preservation;Property;receptor;Receptor Inhibition;recruit;Reflex action;response;Risk;Rodent Model;Serotonin;Serotonin Agents;Serotonin Antagonists;sex;Spastic Cerebral Palsy;spastic motor deficit;spasticity;Spinal;Spinal Cord;Symptoms;Testing;Therapeutic;Therapeutic Intervention;Thinness;Time;Torque;translational approach;Weaning;Work

PROJECT_TITLE: Serotonin Based Therapeutics in Cerebral Palsy

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


PI_NAMEs: PILLOW, JONATHAN WILLIAM (contact)

PROJECT_TERMS: Affect;Animals;Area;Arousal;basal forebrain;Behavior;Behavioral;Biological Assay;biophysical model;Brain;BRAIN initiative;Brain region;cholinergic neuron;Cognitive;Collaborations;Communication;Corpus striatum structure;Data Science;Data Set;Decision Analysis;Decision Making;Dependence;Diameter;Electrophysiology (science);Etiology;Exhibits;experimental study;Fiber;follow-up;Funding;Geometry;Hunger;Hypothalamic structure;Literature;locus ceruleus structure;Measurement;Measures;Memory;Modeling;Mus;neural;neural circuit;Neuroanatomy;neuromechanism;Neurons;Nonlinear Dynamics;noradrenergic;Optics;optogenetics;Outcome;Photometry;Physiological;Physiology;Population;Pupil;Rodent;Sensory;Short-Term Memory;Signal Transduction;Statistical Models;Structure;Testing;theories;Thirst;Time;tool;Training;training data;Work

PROJECT_TITLE: P3: Internal Brain States


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BOSTON

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative: Genetic perturbations underlie many human maladies including diabetes, cancer, and heart disease. Our understanding of the genetic variants contributing to such diseases, the mechanistic underpinning of how these variants contribute to disease, and, most importantly, how we might intervene to fix or ameliorate disease- causing genetic perturbations remains poor. The PGG training program at Harvard Medical School will provide specialized training in the fields of genetics and genomics to our Ph.D. students so that they are prepared to lead our Nation’s efforts towards defining the causes of, and developing treatments for, genetic disease in people.

PI_NAMEs: KENNEDY, SCOTT G (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TITLE: Program in Genetics and Genomics PhD Training Grant

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rehabilitation;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative Asian populations are the fastest growing ethnic group in the United States and the largest group of new immigrants. Rates of childhood cancer are increasing for Asian Americans faster than any other racial or ethnic group; however, Asian American survivors are under-researched. This study will examine the individual, family, and neighborhood factors associated with cancer-focused survivorship care among young adult Asian American childhood cancer survivors to foster healthy survivorship for this patient population.

PI_NAMEs: MILAM, JOEL E;MILLER, KIMBERLY ANN (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: Acculturation;Address;Adult;Aftercare;Age;age related decline;American;Area;Asian;Asian Americans;Asian population;Attitude;barrier to care;Belief;California;cancer prevention;Cancer Survivor;cancer therapy;Caring;Characteristics;Childhood;childhood cancer survivor;Childhood Cancer Survivor Study;Chinese;Chronic;clinically significant;cohort;Consensus;Country;County;Data;Development;Diagnosis;Disparity;ethnic minority;Ethnic Origin;Ethnic Population;experience;Family;Filipino;follow-up;Fostering;Guidelines;Health;Health Care Rationing;health disparity;Health Services Accessibility;Healthcare;Immigrant;Incidence;Individual;Inequity;Insurance;Intervention;Interview;Knowledge;Koreans;Late Effects;Life;Longterm Follow-up;Los Angeles;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Medical;Medical center;Methods;Modeling;Morbidity - disease rate;mortality;Neighborhoods;neoplasm registry;Not Hispanic or Latino;Oranges;outreach;Pacific Islander;Parents;patient population;Patients;Pediatric Oncology Group;Population;population based;prevent;psychosocial outcome;racial minority;racial population;Recommendation;recruit;Research;residence;Risk;Self Efficacy;Seminal;Socioeconomic Status;socioeconomics;Stress;Subgroup;Survey Methodology;Survivors;survivorship;Time;United States;Vietnamese;young adult

PROJECT_TITLE: Individual, cultural, and area-based factors associated with survivorship care among Asian/Asian American childhood cancer survivors


PI_NAMEs: WITTEN, ILANA  (contact)

PROJECT_TERMS: Address;Affect;Area;Basal Ganglia;Behavior;biophysical model;Brain;BRAIN initiative;Brain region;cell type;Cerebellum;Chronic;Cognition;Cognitive;cognitive process;Communication;Computing Methodologies;Contralateral;Corpus striatum structure;Cues;Data;Data Science;Data Set;Decision Making;design;Electrophysiology (science);Etiology;experimental study;Foundations;Geometry;Goals;Image;imaging modality;Individual;insight;Ipsilateral;Lead;Left;Measures;Methods;Modeling;Motor;Motor output;Nature;neural;neural circuit;Neuroanatomy;neuromechanism;Neurons;next generation;Optics;optogenetics;Pathway interactions;Population;Probability;programs;Prosencephalon;Regulation;Resolution;Role;Sensory;Short-Term Memory;Side;Structure;Surveys;System;Technology;Testing;Thalamic structure;theories;Time;transmission process;Variant;virtual reality;Work

PROJECT_TITLE: P4: Multiregion interactions


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Bipolar Disorder;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Psychosis;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative The Populations Underrepresented in Mental illness Association Studies (PUMAS) Project will collect samples from 17,000 individuals with severe mental illness from across African and the Americas to create a total sample dataset of 183,000 from across Africa and the Americas. We will generate and analyze whole genome sequencing data on 40,000 schizophrenia patients, 40,000 bipolar patients and 40,000 controls to learn the similarities and differences of the genetic architecture of severe mental illness across diverse ancestries and environments.

PI_NAMEs: KOENEN, KARESTAN C (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Abbreviations;Africa;African;African ancestry;Americas;Area;Biological;Bipolar Disorder;bipolar patients;Code;cohort;Collaborations;Collection;Computerized Medical Record;Copy Number Polymorphism;Data;Data Set;data sharing;Diagnostic;Disease;Environment;Ethnic Origin;European ancestry;exome;exome sequencing;Gene Frequency;Generations;Genes;Genetic;genetic architecture;Genetic Research;Genetic study;Genetic Variation;genome sequencing;Genomics;Genotype;health care disparity;Individual;insight;International;Interview;knowledge base;Latin American;Latino;Latino Population;Learning;Letters;Linkage Disequilibrium;Maps;Medicine;Mental disorders;Meta-Analysis;Mood Disorders;Mutation;National Institute of Mental Health;Native American Ancestry;Native Americans;neuropsychiatry;Outcome;Patients;Phenotype;polygenic risk score;Population;Population Control;Population Heterogeneity;Principal Component Analysis;psychiatric genomics;Psychiatry;psychogenetics;Psychoses;Psychotic Disorders;Quality Control;Questionnaires;rare variant;recruit;Reduce health disparities;Research Personnel;response;risk variant;Sample Size;Sampling;Sampling Studies;Schizoaffective Disorders;Schizophrenia;screening;severe mental illness;Severities;Single Nucleotide Polymorphism;South Africa;South America;success;Underrepresented Populations;Variant;variant detection;whole genome

PROJECT_TITLE: 2/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African Ancestries


PI_NAMEs: GOLDMAN, MARK S (contact)

PROJECT_TERMS: Animals;Area;Basal Ganglia;Behavior;Brain;BRAIN initiative;Brain region;Breathing;Cerebellum;Cognition;Cognitive;Complex;Computer Models;Control Animal;Corpus striatum structure;Coupled;Cues;Data;Data Analyses;Data Set;Decision Making;entorhinal cortex;Etiology;evidence base;experience;Experimental Models;experimental study;Foundations;Geometry;Goals;Hippocampus;Individual;Joints;Learning;Machine Learning;Maps;Mediating;Memory;model building;Modeling;Motion;Motor;motor control;Neocortex;neocortical;network models;neural;neural circuit;neuromechanism;Neurons;Neurophysiology - biologic function;optogenetics;Pathway interactions;Performance;Positioning Attribute;Prefrontal Cortex;Production;programs;Role;scaffold;Sensory;sensory input;sequence learning;Short-Term Memory;Side;Signal Transduction;sound;Structure;success;System;Task Performances;theories;Training;Variant;Work

PROJECT_TITLE: P5: Mechanistic Multi-Region Brain Models


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Millions of people in the U.S. and worldwide have been diagnosed with Parkinson’s disease, a progressively debilitating disorder characterized by abnormal movement function. Fortunately, many patients with advanced disease who no longer respond adequately to medications have been successfully treated with an FDA- approved implantable device that provides electrical stimulation deep within the brain, a therapy known as deep brain stimulation (DBS). While DBS may significantly reduce symptoms in many cases, there is still much that is unknown about the way it works, especially under different conditions. Our goal is to obtain a better understanding of how DBS and medical therapy change brain function to improve movement in patients with PD and to apply this knowledge to optimize DBS and medical therapy for patients affected by Parkinson’s disease.

PI_NAMEs: VITEK, JERROLD L (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine;advanced disease;Affect;Anatomy;Area;Basal Ganglia;Bradykinesia;Brain;Cells;Characteristics;Coupling;Deep Brain Stimulation;Development;Devices;Diagnosis;Disease;Dorsal;Dyskinetic syndrome;Electric Stimulation;FDA approved;Frequencies;Functional disorder;Gait;Gait abnormality;Globus Pallidus;Goals;gray matter;implantable device;improved;insight;Knowledge;Levodopa;Mediating;Medical;Modeling;Motor;motor control;Motor Cortex;Movement;MPTP non-human primate;Neurons;nonhuman primate;Parkinson Disease;Parkinsonian Disorders;parkinsonian non-human primate;Patients;Persons;Pharmaceutical Preparations;Phase;Phenotype;Population;Prefrontal Cortex;reduce symptoms;Rest;Role;Site;Structure of subthalamic nucleus;Therapeutic Effect;Utah;Work

PROJECT_TITLE: Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian Monkey

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects

ORG_CITY: KARACHI

ORG_COUNTRY: PAKISTAN

ORG_FIPS: PK

ORG_NAME: AGA KHAN UNIVERSITY (PAKISTAN)

PHR: Narrative Building on its 15 years of partnership, Aga Khan University, Johns Hopkins University and George Washington University partnership is well positioned to transition the training and the program leadership to Pakistan as well as expanding the training opportunities to five other countries in East Africa and Central Asia. The program will train several PhD researchers and large number of trainees through a series of workshops, online courses and hands-on research projects and support contextually relevant research in care of the injured with a focus on emergencies, disasters and conflict.

PI_NAMEs: HYDER, ADNAN A;KHAN, NADEEM ULLAH (contact);RAZZAK, JUNAID ABDUL

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Afghanistan;Africa;Asia;Central Asia;Collaborations;Country;Development;Disasters;Distance Learning;Doctor of Philosophy;Emergency Care;Future;Goals;Grant;Growth;Hybrids;Individual;Infrastructure;Injury;Institution;Kenya;Kyrgyzstan;low and middle-income countries;man;mass casualty;Mentors;Mission;Modeling;Pakistan;Phase;programs;Public Health Schools;Recording of previous events;Research;Research Training;Resources;Role;Site;Tajikistan;Tanzania;Training;Training Activity;Training Programs;Trauma;Universities;War;Washington;Work

PROJECT_TITLE: Aga Khan University Trauma and Injury Research Training Program (AKU TIRTP).


PROJECT_TERMS: Administrator;Advisory Committees;Awareness;Behavioral;Books;Boston;Budgets;California;cohesion;Collaborations;Communities;Data Science;Decision Making;design;Educational workshop;Ensure;Equipment and Supplies;Evaluation;Evaluation Research;experimental study;Fostering;Goals;Interview;Laboratories;lectures;Life;Lightning;Link;meetings;member;Methods;Mission;neural;neural circuit;neuromechanism;Occupations;outreach;pandemic disease;Personnel Management;Personnel Recruitments;Postdoctoral Fellow;posters;programs;Publications;Recording of previous events;Reporting;Research;Research Personnel;Research Project Grants;Resources;Schedule;Short-Term Memory;Students;synergism;Time;tool;Translating;Travel;Universities;Update;Visit;web site;Work

PROJECT_TITLE: C1: Administrative


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Data Science;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PROJECT_TERMS: Acceleration;Adopted;Adoption;Algorithms;Anatomy;Automation;Behavior;Behavioral;BRAIN initiative;Calcium;Code;Collaborations;Collection;Communities;computational pipelines;computerized data processing;computerized tools;Computers;Consumption;Data;Data Analyses;Data Collection;data exchange;data handling;data integration;data interoperability;data pipeline;data reuse;Data Science;Data Science Core;data sharing;data standards;Decision Making;distributed archives;Documentation;Electron Microscopy;Electrophysiology (science);Ensure;experience;Feedback;Funding;Geometry;Guidelines;Human;Human Resources;Image;improved;Infrastructure;Laboratories;light microscopy;light weight;Manuals;meetings;Metadata;Methods;Modeling;multiple datasets;Mus;Nature;neural;neural circuit;Neuroanatomy;neuromechanism;neurophysiology;Neurosciences;open-access repositories;Operant Conditioning;Optics;optogenetics;Persons;pharmacologic;Process;programs;Publications;Rattus;Reproducibility;Research;Research Personnel;Research Project Grants;Rodent;segmentation algorithm;sharing platform;Short-Term Memory;Software Tools;Standardization;System;Time;tool;Training;user-friendly;virtual reality;web app;web-based tool;Work

PROJECT_TITLE: C2: Data Science


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

PHR: Project Narrative Placebo effect leads to significant effects on brain excitability and connectivity (plasticity) ultimately influencing clinical outcomes, including motor learning in stroke. This proposal aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subject thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance stroke rehabilitation therapies. This proposal will then provide critical data not only to develop a novel intervention in stroke but also to improve understanding of placebo in stroke clinical trials as to improve its clinical outcomes.

PI_NAMEs: FREGNI, FELIPE  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Accounting;Area;arm;Behavioral;Brain;chronic stroke;Clinical;Clinical Trials;Data;design;Development;disability;Electroencephalography;Electrophysiology (science);Environment;expectation;experience;Fluoxetine;four-arm trial;Future;human old age (65+);improved;indexing;insight;Intervention;Laboratories;Left;Mobility decline;Morbidity - disease rate;Motivation;Motor;Motor Cortex;motor deficit;motor function improvement;motor learning;motor recovery;Multicenter Trials;multidisciplinary;neural;neural circuit;neural model;Neurology;neuromechanism;Neuronal Plasticity;neurophysiology;noninvasive brain stimulation;novel;Operative Surgical Procedures;Outcome;Performance;Physical therapy;Physiologic pulse;pill;Placebo Effect;Placebos;post stroke;Prevalence;Procedures;Protocols documentation;Psychiatry;Quality of life;Randomized;Randomized Controlled Clinical Trials;Rehabilitation therapy;Research;Research Personnel;Rewards;role model;Solid;Stroke;stroke clinical trials;stroke patient;stroke recovery;stroke rehabilitation;stroke trials;System;Testing;Therapeutic;Training;Transcranial magnetic stimulation;trial design;United States National Institutes of Health;Work

PROJECT_TITLE: Mechanisms of Open and Hidden Placebo in Stroke Recovery

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Determining the structures of proteins and their complexes in their cellular environment remains challenging. Large-scale in vivo genotype-to-phenotype and cross-linking mass-spectrometry experiments can interrogate proteins' genetic and physical interactions at a residue-level resolution. In this proposal, we will develop methods to maximally extract structural information from the data derived from these in vivo experiments and apply these methods to determine the structures of biologically relevant protein assemblies, including vaccinia virus protein assemblies, TRIM5α bound to the HIV-1 capsid, and Ddis shuttling factors associated with the proteasome.

PI_NAMEs: ECHEVERRIA RIESCO, IGNACIA  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Archives;Bayesian Modeling;Binding;biological systems;Capsid;Collaborations;Communities;Complex;Computer software;Computing Methodologies;conformer;crosslink;Data;Data Set;empowerment;Environment;experimental study;Genetic;Genotype;HIV-1;Hybrids;in vivo;macromolecular assembly;Maps;Mass Spectrum Analysis;Methods;Modeling;Molecular Conformation;multicatalytic endopeptidase complex;mutant;mutation screening;Noise;open source;Phenotype;programs;protein data bank;protein function;protein structure;Proteins;Research;Resolution;Sampling;structural biology;Structural Models;Structure;System;tool;Vaccinia virus;Validation;Viral Proteins

PROJECT_TITLE: Using in vivo genetic and physical interaction data for structure determination of protein assemblies


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PROJECT_TITLE: C3: Behavior Automation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emergency Care;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Patient Safety;Prevention;Social Determinants of Health;Telehealth

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative. The COVID-19 pandemic outbreak overwhelmed many health care systems despite the increased ability to deliver care remotely and expansions in hospital capacity that the public health emergency made possible. There is, however, limited information on how vulnerable groups of patients fared during the pandemic or why patients in some areas had better or worse outcomes than those in other areas. The complexity of the issues and data to address them makes working together with a national consortium the logical way to address questions of how to manage future outbreaks and identify which changes made during the pandemic should be kept when the pandemic ends.

PI_NAMEs: HSU, JOHN  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Accident and Emergency department;Accounting;Address;Admission activity;advanced directive;Adverse effects;adverse outcome;Affect;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Ambulances;Ambulatory Care;Ambulatory Care Facilities;American;Antipsychotic Agents;Area;Articulation;Attention;Behavioral;beneficiary;Black Box;care delivery;Caregivers;Caring;Censuses;Cessation of life;Clinical;Code;Cognitive;cognitive function;Communities;complex data;County;COVID-19;COVID-19 incidence;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Collection;data resource;Data Set;Death Certificates;Delirium;Diagnosis;Disadvantaged;Disease;Disease Outbreaks;disease transmission;Drug usage;Economically Deprived Population;Economics;Electronic Health Record;Emergency Situation;Employment;Equilibrium;ethnic minority;Ethnic Origin;Event;flexibility;frailty;Future;future outbreak;Goals;Health;health assessment;Health system;Healthcare Systems;hospital care;hospital readmission;Hospitalization;hospitalization rates;Hospitals;human old age (65+);improved;Individual;Infection;inpatient service;Inpatients;Intervention;Learning;Link;Low income;machine learning method;machine learning prediction;Measures;Medical;Medicare;Medicare claim;Methodology;Methods;Modeling;mortality;mortality risk;Natural experiment;Nature;Nursing Homes;older adult;older patient;Outcome;outcome disparities;Outpatients;pandemic disease;pandemic impact;patient home care;Patient-Focused Outcomes;Patients;Pattern;Patterns of Care;payment;Policies;Population;pre-pandemic;predictive modeling;Predisposition;programs;public health emergency;Race;racial minority;Reference Standards;Regulation;Relaxation;remote delivery;remote health care;Reporting;Research;Resources;response;Retirement;Risk Factors;SARS-CoV-2 infection;Shock;social;Social Distance;social factors;Social isolation;Social support;socioeconomic disadvantage;Stress;Surveys;Symptoms;System;telehealth;time use;Travel;Uncertainty;United States National Institutes of Health;Vaccination;Validation;Variant;Viral;Visit;Vulnerable Populations;Waxes;Work

PROJECT_TITLE: Impact of the COVID-19 Pandemic on Patients with Alzheimer's Disease and Alzheimer's Disease Related Dementias


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Biotechnology;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: WANG, SAMUEL SHENG-HUNG (contact)

PROJECT_TERMS: analysis pipeline;Anatomy;Area;Atlases;Brain;Brain region;cell type;Cognition;Collaborations;Communities;Computer software;Data;data exchange;Data Science;Data Set;Decision Making;Democracy;Electron Microscopy;Funding;Gene Expression;Gene Expression Profiling;Geometry;Goals;high throughput technology;Histology;Hour;Human;Image;Image Analysis;image processing;Imaging technology;Immediate-Early Genes;improved;in situ sequencing;in vivo imaging;Laboratories;Learning;Light;Maps;Methods;microscopic imaging;Microscopy;millimeter;Monitor;Mus;neural;neural circuit;Neuroanatomy;neuroimaging;neuromechanism;Neurons;Neurosciences;Optics;Pattern;Preparation;Process;programs;Protocols documentation;Quality Control;reconstruction;relational database;Reproducibility;Research;Research Project Grants;Roentgen Rays;Sampling;scale up;Short-Term Memory;Site;Stains;Standardization;System;Techniques;Thick;Time;Tissue imaging;Tissues;tool;Tracer;transcriptomics;Transmission Electron Microscopy;Viral;Work

PROJECT_TITLE: C4: Neuroanatomy


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Mental Health;Mental Illness;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Primary Health Care;Rehabilitation;Substance Misuse;Telehealth

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE: People who have long term pain and are addicted to opioids or who use their prescription opioids differently from how they were prescribed often suffer with their pain and addiction. To create a research center to help this suffering we would bring together researchers from many backgrounds, people who have long term pain and are addicted to opioids, and groups that provide care for these patients to work together. We plan to develop ways to help patients who receive treatment in their doctor’s office, a specialized treatment program and the hospital.

PI_NAMEs: BARRY, DECLAN T.;BECKER, WILLIAM C (contact);FIELLIN, DAVID

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: acute care;addiction;Address;Alcohol consumption;Anxiety;Biomedical Research;Buprenorphine;Capital;career development;Caring;chronic pain;chronic pain management;chronic pain patient;Clinical;Clinical Psychology;Clinical Trials;Cognitive Therapy;Collaborations;collaborative care;community collaboration;community engaged research;community organizations;compare effectiveness;Cost Analysis;cost effectiveness;Data;depressive symptoms;Development;Discipline of Nursing;Education;effectiveness evaluation;Ethnography;Evidence based intervention;Exercise;experience;Face;Faculty;Funding;Guidelines;Harm Reduction;health care delivery;Health system;Healthcare Systems;Helping to End Addiction Long-term;Home;hospital care;Hospitalization;Hospitals;illicit opioid;implementation facilitation;implementation science;Individual;innovation;Interdisciplinary Study;Internal Medicine;Laws;Leadership;Lived experience;Measurement;Measures;Medical;medical schools;medical specialties;medication for opioid use disorder;Medicine;meetings;Mental Depression;Mentorship;Methadone;Methods;mindfulness;Modeling;multi-site trial;multidisciplinary;multimodality;Neurosciences;novel;novel strategies;Observational Study;operation;Opioid;opioid misuse;opioid treatment program;opioid use;opioid use disorder;Outcome;Outcome Measure;Pain;Pain interference;pain self-management;Patient Care;Patients;peer;Persons;Pharmacists;Pharmacoepidemiology;Pharmacy facility;Physicians;Pilot Projects;prescription opioid;Primary Care;Productivity;Professional Organizations;programs;Psychiatry;Psychology;Psychometrics;Public Health;Qualitative Methods;Qualitative Research;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery;Reproducibility;Research;Research Methodology;Research Personnel;Research Project Grants;Risk;Safety;secondary outcome;Self Management;self-management program;Sleep;Sleep Disorders;Social Medicine;social stigma;Stress;stress management;Symptoms;telehealth;Telemedicine;Telephone;treatment as usual;treatment program;Underrepresented Populations;Work

PROJECT_TITLE: HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers