NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Usher Syndrome

PROJECT_TERMS: Abeta synthesis;abeta toxicity;Affect;age acceleration;age related;Age related macular degeneration;age related neurodegeneration;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Antisense Oligonucleotides;Archives;Area;beta-site APP cleaving enzyme 1;Biochemical;Biology;Blood capillaries;Blood Vessels;Brain;Cells;Chromosome Mapping;circular RNA;Clinical;Collaborations;Data;density;Experimental Ophthalmology;FMR1 gene;founder mutation;Gene Expression;Genes;Goals;Heterogeneous-Nuclear Ribonucleoprotein Group C;Heterogeneous-Nuclear Ribonucleoproteins;Human;Hydroxychloroquine;Malignant Neoplasms;Medicine;Mitochondria;Molecular;Molecular Biology;Mus;Nature;Nerve Degeneration;neurogenesis;Neuronal Differentiation;Neurons;Ophthalmology;Papillary;Parkinson Disease;Pathology;Peptides;Phenotype;Physiology;polygenic risk score;Post-Transcriptional Regulation;Process;Production;programs;Protein Biosynthesis;Psychiatry;Radial;Regulation;Reporting;Research Project Grants;RNA;RNA Binding;RNA-Binding Proteins;Role;senescent cell;Senile Plaques;Sirtuins;Skeletal Muscle;structural biology;Synapses;Testing;transcriptomics;Usher Syndrome;Work

PROJECT_TITLE: ALZHEIMER'S RESEARCH PROJECT: RNA-binding Factors Implicated in Neurogenesis, Alzheimer's Disease, and other Neurodegenerative Pathologies


ACTIVITY: ZIA

ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: NATIONAL INSTITUTE ON AGING

PI_NAMEs: EVANS, MICHELE K (contact)

PROJECT_TERMS: Acceleration;Acute myocardial infarction;Adult;African American;African American population;Age;age acceleration;age group;age related;age related chronic disease;age related decline;Aging;aging biomarker;Anti-Inflammatory Agents;Appearance;Automobile Driving;Basic Science;Behavioral;behavioral health;Biological;Biological Aging;Biological Assay;Biological Factors;Biology;brain health;Cardiac Myocytes;CCL2 gene;Cell Aging;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;Chronic;Clinical Research;Code;Cognition;cohort;comparison group;Complex;Coronavirus;COVID-19 mortality;COVID-19 severity;cytokine;cytokine release syndrome;disability;Discrimination;Disease;Disease susceptibility;Disparate;Disparity;Dissection;DNA;DNA Damage;DNA Repair;Early identification;early onset;Elderly;Environmental Risk Factor;epidemiology study;Epigenetic Process;Etiology;Female;frailty;Gene Expression;Gene Expression Profile;Gene set enrichment analysis;Genes;Genetic;Glucocorticoids;Goals;Health;Health Disparities Research;health disparity;Health Status;healthy aging;high risk;Household;Hydrogen Peroxide;IL1A gene;IL8 gene;Immunity;Income;Individual;Inflammaging;Inflammation;Inflammatory;intercellular communication;Interdisciplinary Study;Interleukin-1 beta;Interleukin-10;Interleukin-4;Interleukin-6;Investigation;Laboratories;Leucine Zippers;Life Expectancy;life span;Link;literacy;Literature;low socioeconomic status;male;Medical;men;middle age;Minority;Molecular;Morbidity - disease rate;mortality;Mus;Neighborhoods;novel;nutrition;Outcome;overexpression;oxidation;Oxidative Stress;Participant;Pathogenesis;Pathologic;Pathway Analysis;Pathway interactions;Peripheral Blood Mononuclear Cell;Phenotype;Physiological;Population;population based;Poverty;Predisposition;Prevalence;Probability;Process;Proteins;Psychosocial Factor;Race;repaired;Research;response;Risk;Risk Factors;Role;Scientist;senescence associated secretory phenotype;Serum;severe COVID-19;Severities;sex;Sex Differences;Signal Pathway;Signal Transduction;sociocultural determinant;Socioeconomic Factors;socioeconomics;Structural Racism;Telomere Shortening;Time;Tissue-Specific Gene Expression;TLR2 gene;TNF gene;Toll-like receptors;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;Untranslated RNA;Virus Diseases;Woman;Work

PROJECT_TITLE: The Underlying Biology of Health Disparities


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Affect;African;African American;African American population;African American Women;African ancestry;Age;age related;age related chronic disease;age-related disease;Baltimore;Biological;Biological Markers;Body Fluids;Cardiovascular Diseases;cardiovascular disorder risk;Categories;Caucasians;CCL2 gene;cell injury;Cell Line;Cell secretion;Cells;Cellular Stress;Circulation;Cities;cohort;Complementarity Determining Regions;Complex;Development;Disease;Disparity;DNA;E-Selectin;ethnic diversity;Ethnic Origin;Ethnic Population;European;European ancestry;extracellular vesicles;Fibrinogen;Future;Genetic;Genetic Polymorphism;Genetic Recombination;Genetic Transcription;Haplogroup;Haplotypes;Health;health disparity;health outcome disparity;healthy aging;Histones;Human;human migration;Hypertension;Incidence;Individual;Inflammation;Inflammatory;inflammatory marker;Inherited;Innate Immune Response;intercellular communication;interest;Interferon Type II;Interleukin-6;Introns;Investigation;Knowledge;Lead;life span;Link;Lipid Binding;Lipids;Literature;Longitudinal Studies;middle age;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Molecular;Morbidity - disease rate;mortality;Mutation;Neighborhoods;novel;Nuclear;Nucleic Acids;Oxidative Phosphorylation;Oxidative Stress;P-Selectin;Participant;Pathway interactions;Pattern;Phylogenetic Analysis;Plasma;Population;Population Heterogeneity;population migration;Populations at Risk;Predisposition;Prevalence;Production;Proteins;Race;racial difference;racial population;Reactive Oxygen Species;Reporting;Research Personnel;Rest;Risk;Risk Factors;Role;Serum;sex;Single Nucleotide Polymorphism;social;Socioeconomic Status;soluble RAGE;Sorting;System;Time;TNF gene;Trees;United States;Untranslated RNA;Variant;Vesicle;Work

PROJECT_TITLE: Interplay between Mitochondrial DNA Haplogroups, Mitochondrial Function, Oxidative Stress, and Hypertension


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

PI_NAMEs: LAUNER, LENORE J (contact)

PROJECT_TERMS: Affect;age acceleration;Alzheimer's Disease;Cells;Complex;Computer software;Data;Dementia;Disease;DNA Methylation;epigenetic clock;Epigenetic Process;epigenome;Etiology;gene environment interaction;Gene Expression;Genetic;genome sequencing;Heart;large datasets;Longitudinal cohort;Methylation;non-genetic;novel;older men;older women;Participant;Phenotype;Preparation;Process;protein expression;Public Health;public health intervention;Research Project Grants;Resources;Risk;Risk Factors;Role;Sampling;Smoking;Technology;Therapeutic;Tissue-Specific Gene Expression;whole genome

PROJECT_TITLE: ALZHEIMER'S RESEARCH PROJECT:  Methylation changes, gene-environment interactions and the occurrence of  Alzheimer's Disease: the AGES-RS Study


PI_NAMEs: SONG, MINKYO  (contact)

PROJECT_TERMS: Adolescence;Adult;Age;age related;age related changes;age-related disease;Aging;Air Pollution;American;Area;Autoantibodies;Autoimmune Diseases;Autoimmunity;Childhood;Complex;design;Diagnosis;Disease;disorder risk;Disproportionately impacts women;Elderly;Epidemiology;Functional disorder;geographic difference;Goals;Immune system;Immunity;immunoreaction;immunosenescence;Individual;Infection;Inflammation;Inflammatory Bowel Diseases;Insulin-Dependent Diabetes Mellitus;Life Cycle Stages;life span;Link;men;Myasthenia Gravis;novel therapeutics;older adult;Onset of illness;Pattern;Persons;Phenotype;pre-clinical;Predisposition;Prospective Studies;Proteins;Research;Rheumatoid Arthritis;Risk Factors;sex;vaccine response;Woman

PROJECT_TITLE: Autoimmunity and Aging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences

PI_NAMEs: WENG, NAN-PING PETER (contact)

PROJECT_TERMS: 3xTg-AD mouse;Adult;Affect;aged;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer’s disease biomarker;Antibodies;Antigens;APP-PS1;Baltimore;Brain;Cancerous;Catchment Area;CD8-Positive T-Lymphocytes;cell killing;Cells;chemokine;Clonal Expansion;cognitive performance;cytokine;Cytomegalovirus;cytotoxic;cytotoxicity;Epidemiology;Herpesvirus Type 3;Human Herpesvirus 4;Immune;Immune response;immunoregulation;Impaired cognition;Individual;Infection;infection burden;Inflammatory;Interferons;mental state;Modeling;mouse model;Mus;neuroinflammation;Pathogenesis;Pathologic;Pathology;perforin;Performance;Phenotype;Production;Research;Research Project Grants;Role;Simplexvirus;T cell infiltration;T-Cell Receptor;Testing;Toxoplasma gondii;verbal

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT:  Role of CD8 T cell in the pathogenesis of Alzheimer's disease


NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: SEN, PAYEL  (contact)

PROJECT_TERMS: 3-Dimensional;Adopted;Age;age related;Aging;ATAC-seq;attenuation;Body Weight;Cell Count;Cell Physiology;Chemical Injury;Chromatin;Cleavage Under Targets and Release Using Nuclease;Collagen;Data Analyses;Down-Regulation;Elderly;Enhancers;Epigenetic Process;epigenome;experimental study;Gene Expression;Genes;Genome;histone acetyltransferase;Histones;Human;Immune;immunoregulation;improved;Inflammation;inhibitor;Investigation;loss of function;Maps;Messenger RNA;Metabolic;Multiomic Data;Mus;Muscle;muscle aging;muscle form;muscle progenitor cell;Natural regeneration;old mice;Organ;Post-Translational Protein Processing;regeneration function;Regenerative capacity;sarcopenia;Skeletal Muscle;stem cell niche;stem cells;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptome sequencing;Up-Regulation

PROJECT_TITLE: Epigenetic mechanisms of muscle aging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

PROJECT_TERMS: Acetylation;age group;age related;Age-associated memory impairment;Aging;aging brain;Alzheimer's Disease;Alzheimer's Disease Pathway;astrogliosis;Automobile Driving;Autopsy;Biopsy;Brain;Cognitive deficits;cognitive function;Complement Activation;CREBBP gene;design;Disease;Enhancers;EP300 gene;Epigenetic Process;Etiology;Event;expectation;Female;Fiber;Gene Expression;Genomics;glial activation;Histone Acetylation;histone acetyltransferase;Histone Deacetylation;Human;Infiltration;Inflammatory;interest;Learning;machine learning algorithm;Mediating;Memory;Messenger RNA;Molecular;Mus;Myeloid Cells;Paracrine Communication;Pathologic;Play;preservation;Proteins;Publishing;Research Project Grants;Role;sex;spatiotemporal;Tail;Therapeutic;transcription factor;transcriptomics;white matter

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT - Epigenetic mechanisms of brain aging


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Prevention;Sleep Research;Social Determinants of Health

PI_NAMEs: HUANG, TIANYI  (contact)

PROJECT_TERMS: Accelerometer;Age;Aging;aging related;Asia;Behavioral;biobank;Biological;Cardiovascular system;Caring;Categories;Cessation of life;Chronic Disease;Cluster Analysis;Cohort Studies;comorbidity;Cox Proportional Hazards Models;Data;Development;Diabetes Mellitus;diabetes risk;Diagnosis;Dimensions;Disease Outcome;disorder risk;Disparity;Drowsiness;Environmental Risk Factor;Factor Analysis;follow-up;Genetic Risk;hazard;Health;health disparity;Hour;Individual;insight;Knowledge;Life Style;Malignant Neoplasms;Measurement;Measures;Medical Records;Metabolic;Methods;Modeling;Multi-Ethnic Study of Atherosclerosis;Neurodegenerative Disorders;novel;Obesity;Participant;Patient Self-Report;personalized intervention;Persons;polygenic risk score;Population;prospective;Prospective Studies;Prospective, cohort study;Publishing;Race;Reproducibility;Risk;Role;Sampling;sex;Sleep;Sleep Apnea Syndromes;Sleep Architecture;sleep health;sleep pattern;sleep quality;Sleep Stages;Snoring;social;social factors;sociodemographics;Time;Variant;Wakefulness;Well in self

PROJECT_TITLE: Multi-Dimensional Sleep Health and Aging-Related Chronic Disease Risk


NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Nutrition;Obesity;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Adult;Affect;African American;African American population;age acceleration;age related;aging process;Apoptotic;Attention;Biological Markers;Black American;Body mass index;Body System;Categories;caucasian American;Cell Aging;cell injury;Cell Physiology;Cells;Characteristics;Chronic Kidney Failure;cohort;Communication;comorbidity;Development;Disease;Disparate;Disparity;DNA;End stage renal failure;Endothelial Cells;Environment;exosome;extracellular;Extracellular Space;extracellular vesicles;Functional disorder;Health;health disparity;healthy aging;High Prevalence;human old age (65+);Hypertension;Incidence;Individual;Inflammation;Inflammatory;insight;Kidney Diseases;Kidney Failure;Knowledge;life span;Link;Lipids;Longitudinal cohort;Mediator;microvesicles;minimally invasive;Mitochondrial DNA;Molecular;mortality;Nature;Neighborhoods;Non obese;Nucleic Acids;obese patients;obese person;Obesity;Obstructive Sleep Apnea;Older Population;Overweight;particle;Patients;Pattern;Plasma;Play;Population;Proteins;Proteinuria;racial population;Reporting;Research;Risk;Risk Factors;RNA;Role;socioeconomics;Structure;Tissues;United States

PROJECT_TITLE: Investigating Extracellular Vesicles as a Link Between Obesity and Chronic Kidney Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: SINGLETON, ANDREW  (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;advanced analytics;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;ancestry analysis;Area;Artificial Intelligence;Attention;Baltimore;base;Bibliography;biobank;Biological Markers;Biological Products;biomarker discovery;Body Composition;brain magnetic resonance imaging;Brain Mapping;Cells;cerebral atrophy;Chromosome Mapping;Clinical;clinical center;Clinical Data;clinical trial recruitment;Code;Cognitive;Cognitive aging;Collaborations;Common Data Element;Communities;Complex;complex data;Computerized Medical Record;cost;CRISPR interference;Data;data access;Data Analyses;data analysis pipeline;Data Files;data harmonization;data integration;data integrity;data management;data privacy;data quality;Data Science;Data Set;data sharing;Data Sources;data visualization;deep learning;Dementia;dementia risk;Democracy;design;Development;Disease;Disease Progression;Disparate;Distal;empowerment;Ensure;Environment;Equipment and supply inventories;Ethics;Extramural Activities;FAIR principles;federated learning;Feedback;follow-up;frailty;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;Genetic;Genetic Diseases;Genetic Risk;Genetic study;Genetic Variation;genomic data;Genomics;Goals;GP2 gene;Growth;hackathon;Health;Heterogeneity;Home;Hour;Human;human induced pluripotent stem cells;Image;improved;Infrastructure;insight;Institution;interest;invention;Investigation;Knowledge;large language model;Lewy Body Dementia;Libraries;Life;light weight;Longitudinal Studies;Machine Learning;Manuscripts;Maps;Mediation;Medical center;member;Meta-Analysis;Metadata;Methods;Microglia;Mississippi;Modeling;Molecular;multimodal data;multimodality;multiple data types;Multiple Sclerosis;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;online resource;Onset of illness;open source;Outcome;Parkinson Disease;Participant;Patients;Pattern;Persons;Phenotype;Process;Psychiatry;Public Domains;Publications;Publishing;PubMed;Quality Control;Reporting;repository;Research;Research Institute;Research Personnel;Resources;Risk;Risk Factors;risk prediction;risk variant;Sampling;Scientist;serial imaging;sharing platform;Sleep disturbances;Standardization;stem;systematic review;Time;tool;Training;United States National Institutes of Health;United States National Library of Medicine;Universities;unsupervised learning;usability;Viral;Virus Diseases;Vision;Work

PROJECT_TITLE: Center for Alzheimer's and Related Dementias (CARD):  Harmonized Data-Derived Resources for the Alzheimer's Disease and Related Dementias Community


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Acceleration;advanced analytics;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;analysis pipeline;Area;Back;C9ORF72;Cell Culture Techniques;Cell Differentiation process;Cell Line;Cell Physiology;Cells;cellular imaging;Cellular Morphology;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;complement resource;CRISPR interference;Data;Data Set;Development;Disease;Disease Pathway;Drug Targeting;empowerment;Engineering;Female;Future;gene function;Gene Mutation;Genes;Genetic;genetic variant;Heterozygote;Individual;induced pluripotent stem cell;Inherited;Laboratories;Libraries;Maintenance;male;Manuscripts;Methods;Microglia;Microscopy;Multiomic Data;Mutation;Neurodegenerative Disorders;Neurons;novel;online repository;Paint;Patients;Pharmaceutical Preparations;phenotypic data;Precision medicine trial;Preparation;Proteomics;Protocols documentation;prototype;Publishing;repository;Reproducibility;Resources;screening;Single Nucleotide Polymorphism;single-cell RNA sequencing;supervised learning;Supporting Cell;targeted treatment;tool;transcriptomics;Work

PROJECT_TITLE: Center for Alzheimer's and Related Dementias (CARD):  iPSC Neurodegenerative Diseases Initiative


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Binding;Cell model;Chemicals;drug candidate;Excision;interest;Lead;Ligands;Methods;multicatalytic endopeptidase complex;Neuroanatomy;novel therapeutics;Oncology;pharmacologic;Protac;protein aggregation;protein degradation;Proteins;Research;Risk;scaffold;tau aggregation;tau Proteins;Technology;Testing;Therapeutic

PROJECT_TITLE: Center for Alzheimer's and Related Dementias (CARD): Pharmacological Targeting of Tau Aggregates for Autophagic Removal in Alzheimer's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Nanotechnology;Neurodegenerative;Neurosciences

PROJECT_TERMS: African ancestry;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Automobile Driving;Benchmarking;Bioinformatics;Blood;Brain;brain tissue;Cell Separation;Cells;Centromere;Clinical;cloud based;Code;cohort;Collection;Communities;community empowerment;computerized tools;Data;Data Analyses;Dideoxy Chain Termination DNA Sequencing;Disease;DNA;DNA sequencing;Elements;Epigenetic Process;European ancestry;experimental study;falls;Freezing;frontal lobe;Frontotemporal Dementia;GC Rich Sequence;Generations;Genetic;genetic architecture;genetic variant;genome sequencing;Genomic Segment;Genomics;Genotype;Human;improved;induced pluripotent stem cell;Infrastructure;insertion/deletion mutation;interest;large datasets;Latin American;Length;Lewy Body Dementia;Manuscripts;Memory;Methods;Names;nanopore;National Human Genome Research Institute;Nature;Neurosciences;Nucleotides;Pathologic;Phase;Population Heterogeneity;Process;Protocols documentation;Publishing;religious order study;Repetitive Sequence;Sampling;sharing platform;Technology;telomere;tool development;Underrepresented Populations;Variant;variant detection;whole genome;Writing

PROJECT_TITLE: Center for Alzheimer's and Related Dementias (CARD): Long-read DNA sequencing of Alzheimers Disease and Related Dementias cases


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: COOKSON, MARK  (contact)

PROJECT_TERMS: Age;age related;aged;Aging;Alzheimer's Disease;Apolipoprotein E;Astrocytes;ATAC-seq;Brain;Brain region;Cell Nucleus;cell type;Cells;Characteristics;Communication;Data;Data Analyses;Disease;disorder risk;entorhinal cortex;excitatory neuron;follow-up;Gene Expression;gene synthesis;Genes;Genetic Transcription;genome wide association study;Genomics;Gliosis;healthy aging;Human;inhibitory neuron;Laboratories;life span;LRRK2 gene;Maps;Microglia;Minor;Modality;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuron loss;Neurons;Nuclear;oligodendrocyte progenitor;Parkinson Disease;Phenotype;precursor cell;Protein Biosynthesis;putamen;Research Project Grants;Resources;risk variant;Sampling;Series;Signal Transduction;single nucleus RNA-sequencing;Stereotyping;Structure of middle temporal gyrus;subventricular zone;targeted treatment;Testing;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: ALZHEIMERS RESARCH PROJECT:  Developing a single cell map of the aging human brain relevant to Alzheimer's disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PI_NAMEs: CAI, HUAIBIN  (contact)

PROJECT_TERMS: Affect;Afferent Neurons;Alzheimer's Disease;Alzheimer's disease related dementia;arm;Association Learning;Behavior;Behavioral;CAV2 gene;cohort;comparison control;conditioned fear;Cues;Data;Dementia;design;designer receptors exclusively activated by designer drugs;Discrimination;discrimination task;Dopamine;dopaminergic neuron;entorhinal cortex;episodic like memory;Episodic memory;Exhibits;experience;experimental study;Extinction;fear memory;Fiber;Freezing;Fright;Genetic;Glutamate Transporter;Glutamates;Imaging Techniques;Impaired cognition;Impairment;Lateral;Learning;Lesion;Memory;Memory impairment;Midbrain structure;multisensory;Mus;Neurons;non-motor symptom;novel;odor discrimination;Parkinson Disease;Patients;Performance;Phase;Photometry;Play;Population;Protocols documentation;Radial;receptor;Research;Research Project Grants;Rewards;Role;Satiation;Synapses;Tactile;Testing;Time;Transfection;vector;Ventral Tegmental Area;Virus;Visual

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT:  Pathophysiological Study of Dopamine in Alzheimer's Disease and Related Demantia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: ALS patients;Alzheimer's Disease;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Biological Assay;Biological Markers;case control;Central Nervous System;Cerebrospinal Fluid;Clinical;clinical application;college;Communities;Data;Detection;Disease;Exons;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Goals;Human;human tissue;Induced pluripotent stem cell derived neurons;industry partner;Lead;London;Manuscripts;Mass Spectrum Analysis;Monoclonal Antibodies;Nature;novel;Pathology;Patients;Peptides;Plasma;polyclonal antibody;Progressive Supranuclear Palsy;protein biomarkers;protein TDP-43;Proteins;Publications;Publishing;PubMed;Risk;RNA;RNA Splicing;Sampling;Specificity;Transcript;translational medicine;Translational Research;two-dimensional;Universities

PROJECT_TITLE: Center for Alzheimer's and Related Dementias: Detection of cryptic exons (splicing differences) in TDP-43 as biomarkers for frontotemporal dementia and Alzheimer's disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PROJECT_TERMS: advanced analytics;Age;Alzheimer's Disease;Alzheimer's disease related dementia;American;Atlases;biobank;Brain;brain cell;Brain region;brain tissue;cell type;Cells;Clinic;Collaborations;Collection;Communities;Data;Disease;epigenomics;Genetic;genetic variant;Goals;Hippocampus;Human;Individual;Lewy Body Dementia;Manuscripts;Medical;member;Michigan;Molecular;Multiomic Data;multiple omics;Neurodegenerative Disorders;Neurologic;Parkinson Disease;Population;Population Heterogeneity;Prefrontal Cortex;Process;Protocols documentation;Quantitative Trait Loci;Research;Resources;Sampling;Small Nuclear RNA;Source;Substantia nigra structure;Tissues;tool;transcriptome sequencing;transcriptomics;translational genetics;United States National Institutes of Health;Universities;user-friendly;Work

PROJECT_TITLE: Center for Alzheimer's and Related Dementias: First stage single-cell brain resource for Alzheimer's disease and related dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: African American;Alaska Native;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Apolipoprotein E;Astrocytes;Catalogs;Cell Line;Collaborations;Communities;Data;experimental study;functional genomics;Generations;genetic risk factor;Genotype;Goals;Growth;Hispanic Americans;Indiana;Individual;induced pluripotent stem cell;Inosine Dialdehyde;Latin American;meetings;Microglia;Minority Groups;Native Americans;Native Hawaiian or Other Pacific Islander;neuroimaging;Neuronal Differentiation;Patients;Peripheral Blood Mononuclear Cell;Research;Research Personnel;Resources;Sampling;Underrepresented Minority;United States National Institutes of Health;Universities;whole genome

PROJECT_TITLE: Center for Alzheimers' and Related Dementias: iPSCs to study Diversity in Alzheimers disease and Alzheimers disease-related dementias (iDA)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: RYAN, VERONICA  (contact)

PROJECT_TERMS: advanced analytics;Alzheimer's Disease;Alzheimer's disease related dementia;Axon;Biology;Cell Line;Code;Communities;CRISPR interference;Data;data analysis pipeline;Data Set;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genetic;Goals;induced pluripotent stem cell;Inherited;knock-down;Messenger RNA;Mutation;Neurodegenerative Disorders;Neurons;Pathway interactions;Pilot Projects;prevent;Proteomics;Research;Research Project Grants;Resources;RNA Transport;RNA-Binding Proteins;therapeutic target;transcriptomics;Translations;Work

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: RNA Transport and Local Translation in Alzheimer's and Related Dementias (ADRD)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: advanced analytics;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;ancestry analysis;Argentina;Brazil;Chile;clinical research site;cohort;Collaborations;Colombia;Communities;Country;Data;Data Set;Dementia;dementia risk;Foundations;Frontotemporal Dementia;Funding;Future;Genetic;genetic analysis;Genetic Risk;Grant;International;Latin America;Latin American;Leadership;Learning;Manuscripts;Mexico;Participant;Patients;Peru;Population;Population Heterogeneity;posters;Psychiatry;Publications;Publishing;recruit;Research;sabbatical;Sampling;symposium;Training

PROJECT_TITLE: Center for Alzheimer's and Related Dementias (CARD): Collaboration with the Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: Alzheimer's disease related dementia;Behavioral Mechanisms;Blood Vessels;Cardiovascular system;Cognitive;Collaborations;Complement;Data;data access;Data Analytics;data harmonization;data science resource;Data Set;data sharing;Democracy;Disparity;Future;Generations;Genetic;Genotype;geographic disparity;Goals;improved;Intervention;middle age;Minority Groups;Neurodegenerative Disorders;Pathway interactions;Positioning Attribute;racial disparity;Reasons for Geographic And Racial Differences in Stroke;Reporting;Research;Research Activity;Resources;social;vascular cognitive impairment and dementia;Work

PROJECT_TITLE: Center for Alzheimer's and Related Dementias (CARD): Collaboration with the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Biological Assay;Biological Markers;Cognitive;comorbidity;Concha;corticobasal syndrome;Data;Dementia;Development;Disease Progression;Goals;Impaired cognition;Individual;Lewy Bodies;mild cognitive impairment;Molecular;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;Neurologic;Paralysed;Participant;Pathology;Patients;Prevalence;Printing;Publishing;synuclein;Technology;timeline;Work

PROJECT_TITLE: Center for Alzheimer's and Related Dementias: -synuclein seed amplification assay in Alzheimer's disease


NIH_SPENDING_CATS: Aging;Genetics;Neurosciences

PI_NAMEs: LIU, YIE  (contact)

PROJECT_TERMS: Affect;age related biomarkers;age related changes;Age related pathologies;age-related disease;Aging;aging process;aging related;Alzheimer’s disease biomarker;Apoptotic;Biological;Biological Assay;Biological Markers;Biology;Bone Marrow;Brain;CCL2 gene;Cells;Characteristics;chemokine;Chronic;cohort;Communication;Complex;CXCL9 gene;cytokine;Cytokine Network Pathway;Data;Defect;Development;Disease;DNA;Exhibits;exosome;Exposure to;extracellular;extracellular vesicles;Future;Generations;hallmarks of aging;Heart;Human;IL2 gene;IL7 gene;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;Inflammatory Response;interest;Interferon Type II;Investigation;Knockout Mice;Link;Liver;Malignant Neoplasms;Mediating;Mediator;microvesicles;Molecular;mouse model;Mus;Muscle;Nerve Degeneration;Neurons;neurotoxicity;Outcome;particle;Pathology;Plasma;Proliferating;prospective;Proteins;Proteomics;replication stress;Research;response;RNA-Directed DNA Polymerase;Role;Science;Signal Pathway;Signal Transduction;Small Intestines;Source;Spleen;Surface;targeted treatment;Telomerase;telomere;telomere loss;Telomere Shortening;Therapeutic Intervention;Tissues;Up-Regulation;Variant;Work

PROJECT_TITLE: Investigation of the intracellular and extracellular mechanisms underlying the process of aging


PI_NAMEs: BROSH, ROBERT  (contact)

PROJECT_TERMS: Aging;Arginine;ATP phosphohydrolase;Autoantibodies;Autoimmune Diseases;cell type;Cellular translocation;Child;Collaborations;Cytoplasm;Development;Disease;DNA Repair;Double-Stranded RNA;Etiology;Genes;helicase;Helicase Gene;Impairment;In Vitro;Inflammation;Interferon Activation;Juvenile Dermatomyositis;Lung Diseases;mutant;Mutate;Mutation;Myositis;National Institute of Allergy and Infectious Disease;National Institute of Environmental Health Sciences;Nucleic Acids;Oxidative Stress Induction;Pathogenicity;Pathway interactions;Patients;protein function;Proteins;Research;response;Role;skin disorder;systemic autoimmune disease;Systemic disease;Viral;Work

PROJECT_TITLE: Functional Significance of Mutations in Helicase Genes in Patients with Juvenile Dermatomyositis and anti-MDA5 Autoantibodies


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: 2019-nCoV;Age related comorbidities;aging population;Anti-viral Agents;Anti-viral Therapy;Binding;Biochemical;Biological Assay;biophysical properties;Collection;Combined Modality Therapy;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 vaccine;Development;Elderly;Future;Goals;helicase;high risk;high throughput screening;Immune;Immune System Diseases;Immunologics;immunosenescence;infection risk;inhibitor;Intervention;Life Cycle Stages;Medical;Medicine;Molecular;Molecular Bank;Molecular Target;mortality risk;novel;novel therapeutics;Nucleic Acids;Nucleotides;Nursing Homes;Older Population;Pathogenesis;Polymerase;Proteins;remdesivir;repository;Research Personnel;Research Proposals;Resolution;RNA;RNA-Directed RNA Polymerase;SARS-CoV-2 inhibitor;small molecule;small molecule inhibitor;small molecule libraries;Social Distance;Structure;Structure-Activity Relationship;Therapeutic;Viral;Virus;Virus Replication

PROJECT_TITLE: Molecular Characterization of the SARS-CoV-2 Helicase and High-Throughput Screening to Identify Small Molecule SARS-CoV-2 Helicase Inhibitors as Anti-Viral Medicines


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: BIRAGYN, ARYA  (contact)

PROJECT_TERMS: Ablation;adaptive immunity;Affect;Aging;Alzheimer like pathology;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloidosis;Antibodies;astrogliosis;Autopsy;B-Lymphocytes;Brain;brain parenchyma;CD8-Positive T-Lymphocytes;Cells;Complex;CXCR6 gene;Data;Databases;Dementia;Deposition;Disease;Disease associated microglia;Early Onset Alzheimer Disease;ecto-nucleotidase;Event;exhaust;Genetic;Human;Immunization;Infiltration;Link;Mediating;Memory;Microglia;Mus;Nature;Neuronal Dysfunction;neurotoxic;Pathogenicity;Pathologic;Peptides;Peripheral;Phenotype;Play;Publications;Reporting;Research Project Grants;RNA vaccine;Role;Synapses;T cell infiltration;Tauopathies;Testing;Tissues;Work

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: B cells promote Alzheimers disease via cytolytic CD8+ T cells


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Genetics;Neurosciences;Nutrition;Prevention

PI_NAMEs: ACOSTA-RODRÍGUEZ, VICTORIA  (contact)

PROJECT_TERMS: age related chronic disease;Aging;Behavioral;Chronic Disease;circadian;circadian pacemaker;dietary;Dietary Intervention;Eating;Energy Metabolism;Feeding Patterns;Gene Expression;gene therapy;Genes;Goals;Health;healthspan;Hour;immune function;insight;Intervention;lens;life span;Longevity;Longevity Pathway;multiple omics;novel;novel therapeutic intervention;Nutrient;Periodicity;Personal Satisfaction;pharmacologic;Physiological;Physiology;prevent;Process;Research;response;Role;Sampling;System;Time;Tissues

PROJECT_TITLE: Understanding the role of circadian clocks on healthy longevity


NIH_SPENDING_CATS: Aging;Cardiovascular;Dental, Oral, and Craniofacial Disease;Heart Disease;Neurosciences;Physical Activity;Regenerative Medicine;Wound Healing and Care

PI_NAMEs: LAKATTA, EDWARD  (contact)

PROJECT_TERMS: Acceleration;Affect;age acceleration;Age Months;age-related disease;Aging;aging process;Alzheimer's Disease;Animal Model;Animals;Anxiety;arterial stiffness;Arthritis;ATP phosphohydrolase;Birth;Blood specimen;Blood Vessels;Calcium Signaling;Cardiac;Cardiovascular system;Carpal Tunnel Syndrome;Cell Aging;Cell Separation;Cessation of life;Chronic;Clinical Research;cohort;cytochrome c oxidase;Dentistry;diabetic patient;dosage;Echocardiography;Elderly;Environment;epigenetic clock;Experimental Autoimmune Encephalomyelitis;Female;Fibroblasts;Food;frailty;Gait;Gait speed;Goals;Health;healthspan;Heart;heart function;Heart Rate;heart rate variability;Hemostatic function;Human;Hypertension;In Situ;Inflammation;Leg Ulcer;Length;life span;Light;Long-Term Effects;Major Depressive Disorder;male;Measurement;Mitochondria;mouse model;Mus;Myalgia;Myocardial Infarction;myogenesis;novel therapeutics;oral mucositis;overexpression;Pathway interactions;Phenotype;Physics;Physiological;pre-clinical;Process;programs;Regulation;Reporting;Role;senescence;Siblings;Signal Transduction;Skeletal Muscle;Smooth Muscle Myocytes;Spinal cord injury;stem cells;Stroke;Sunlight;telomere;Testing;Therapeutic Effect;therapeutic evaluation;tissue regeneration;Tissues;Transgenic Mice;Treadmill Tests;Treatment Efficacy;Vascular Smooth Muscle;Water;wound healing

PROJECT_TITLE: Effect of Long-term Photobiological Modulation Therapy on Aging


PROJECT_TERMS: 3' Untranslated Regions;Action Potentials;age related changes;Aging;American Heart Association;Angiotensin II;Animal Model;Aorta;Binding;Biological Assay;Blood Vessels;Body Composition;Calcium;Cardiac;Cardiac Myocytes;Cardiovascular system;Carotid Arteries;CCL2 gene;CCR;Cell Separation;Cells;Collaborations;comorbidity;Core Facility;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;Diabetic mouse;diabetic rat;Disease;Doctor of Medicine;Doctor of Philosophy;Dose;Echocardiography;Elderly;Electric Stimulation;Exhibits;Extracellular Matrix;Family;Family member;Fibrosis;Functional disorder;Gene Expression;Genetic Transcription;glucose metabolism;Heart;Heart failure;heart function;High Fat Diet;Human;IL6 gene;Immunohistochemistry;Inflammatory;Insulin Resistance;Knock-out;Knockout Mice;Link;Longitudinal Studies;Luciferases;Macaca mulatta;Magnetic Resonance Imaging;Manuscripts;meetings;Messenger RNA;Metabolism;migration;morphometry;Mus;Myocardial;novel;Obesity;OGTT;old mice;overexpression;Oxidative Stress;Oxidative Stress Induction;Performance;posters;Proteins;Protocols documentation;PTGS2 gene;Publications;Rattus;Receptor, Angiotensin, Type 1;Renin-Angiotensin-Aldosterone System;Role;Science;Signal Transduction;SIRT1 gene;Smooth Muscle Myocytes;Sterility;Streptozocin;Testing;Tissues;transcriptome;transcriptome sequencing;Universities;Untranslated RNA;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Non-coding RNAs (ncRNAs) in Cardiovascular Aging


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cardiovascular;Genetics;Heart Disease;Neurosciences

PROJECT_TERMS: Acceleration;Adenylate Cyclase;Adult;Affect;Age;age acceleration;Age Months;age related;Aging;Appearance;Behavior;behavior test;Bioinformatics;biological adaptation to stress;Brain;brain tissue;Calcium;Cardiac;cardiac aging;Cardiac Myocytes;Cell Survival;Cells;Central Nervous System;Chronic;conditioned fear;coronary fibrosis;Cyclic AMP-Dependent Protein Kinases;cytokine;Darkness;Dopamine;Electrocardiogram;Electroencephalography;Endothelial Cells;Etiology;Exercise;experience;Freezing;gamma-Aminobutyric Acid;Generations;Genes;Genetic Transcription;Genotype;Glutamates;Heart;heart function;Heart Rate;Hippocampus;Immune;immune activation;Immune response;in vivo;Inflammation;Inflammatory;Label;Lead;Left;Left ventricular structure;Light;Locomotion;Longevity;lymphoid organ;MAP Kinase Gene;Mediating;Messenger RNA;Metabolic Pathway;Metabolism;Modeling;Molecular;Motor Activity;Mus;Myocardial;Myocardial dysfunction;new therapeutic target;novel;Output;overexpression;Pathway interactions;PDPK1 gene;Performance;Phosphopeptides;Phosphoproteins;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;PI3K/AKT;PIK3CG gene;Post-Translational Protein Processing;Proteins;Proteome;Proteomics;PTK2B gene;Publishing;Quality Control;receptor;Reporting;resilience;response;Role;Serum;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Speed;Stress;Stress Response Signaling;System;systemic inflammatory response;Telemetry;Testing;Time;Tissues;transcription factor;transcriptome;transcriptomics;Travel;Ubiquitin;Up-Regulation;Variant;Ventricular;Wild Type Mouse

PROJECT_TITLE: The TGAC8 Mouse, the mouse that roars


NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease

PROJECT_TERMS: Action Potentials;Adrenergic Receptor;Age;Animals;Behavior;Binding;Biological Pacemakers;Brain Death;Cardiovascular Diseases;Cell Therapy;Cells;cost;Coupled;Couples;Coupling;Cyclic AMP;Devices;Electrocardiogram;Exhibits;Failure;Fractionation;Frequencies;Generations;Heart;Heart Rate;Human;implantation;in vivo;Ion Channel;Kinetics;Laws;Membrane;Molecular;Mus;Neurons;new therapeutic target;nodal myocyte;Pacemakers;Periodicals;Periodicity;Phase;receptor;Regulation;Research;Rest;Sarcoplasmic Reticulum;Scientist;Signal Transduction;Sinoatrial Node;Sinus;spatiotemporal;Surface;System;Testing;Time;Tissues;voltage

PROJECT_TITLE: Beat to beat Ca2+-dependent regulation of pacemaker cell rate and rhythm


PI_NAMEs: FEDOROVA, OLGA V (contact)

PROJECT_TERMS: Age;Aging;Animal Model;Animals;Aorta;arterial stiffness;Behavioral;Blood Pressure;blood pressure regulation;Blood Vessels;Brain;Breeding;bufadienolide;Cardiovascular system;cerebrovascular;Chronic;cognitive function;Collagen;Collagen Gene;Complex;connective tissue growth factor;Consumption;Dahl Hypertensive Rats;Dementia;dementia risk;Diet;dietary;dietary control;Dietary intake;dietary salt;early experience;Echocardiography;experimental study;Fibronectins;Fibrosis;Gene Expression;Genes;Genetic;Goals;Heart;high salt diet;Hippocampus;Hypertension;hypertensive;Impaired cognition;Impairment;inhibitor;Intake;Investigation;male;marinobufagenin;Memory;Modeling;morris water maze;Na(+)-K(+)-Exchanging ATPase;new therapeutic target;normotensive;Outcome;Performance;Plasma;Profibrotic signal;Rattus;response;salt intake;salt sensitive hypertension;Sodium Chloride;Sodium-Restricted Diet;spatial memory;Sprague-Dawley Rats;Structure;Testing;TGFB1 gene;Up-Regulation;Urine;Weight

PROJECT_TITLE: Sodium pump inhibitors in blood pressure regulation and in profibrotic signaling in salt sensitive hypertension and aging


NIH_SPENDING_CATS: Aging;Biotechnology;Contraception/Reproduction;Genetics;Human Genome;Women's Health Research

PI_NAMEs: NAGARAJA, RAMAIAH  (contact)

PROJECT_TERMS: Affect;African;age related;aging related;Agonist;Agreement;Alternative Splicing;American;Amino Acids;Antibodies;Bacterial Artificial Chromosomes;Binding;Biochemical;Bioinformatics;Blood;C-terminal;cancer cell;Cancer cell line;Catalogs;Cell Line;Cells;Centromere;Chromatin;Chromosome 14;Chromosome 21;Chromosome 22;Chromosomes;Cloning;Code;Collaborations;Complement;Complex;Data;Databases;desmoglein;Desmosomes;Developmental Process;Diabetes Mellitus;DNA analysis;DNA Sequence;DNA Structure;East Asian;Embryo;ERR1 protein;Evolution;Exhibits;exosome;falls;follow-up;Future;Gel;Genbank;Gene Expression Regulation;gene repression;Genes;Genetic Recombination;Genetic Transcription;genetic variant;Genome;Gorilla gorilla;Growth;Guanine + Cytosine Composition;Haploidy;Heterogeneity;Homo sapiens;Human;Human Chromosomes;Human Genome;Hybrid Cells;Hybrids;insertion/deletion mutation;interest;Large T Antigen;Leucine;Macaca mulatta;Manuscripts;Mediating;Metabolic Diseases;Mole the mammal;molecular sequence database;Monkey Cell Line;Mothers;mRNA Translation;Mus;nanopore;National Human Genome Research Institute;Nature;nonhuman primate;Nuclear Receptors;Nucleoproteins;Open Reading Frames;Pan Genus;Pan paniscus;pan-genome;Personal Satisfaction;Placenta;Pongo pygmaeus;Population;Positioning Attribute;Pre-Eclampsia;Predisposition;Pregnancy;preservation;programs;promoter;Promoter Regions;Property;Proteins;Publications;Publishing;receptor;Recovery;recruit;Regulation;Repetitive Sequence;Reproduction;Retinoic Acid Receptor;Ribosomal DNA;Ribosomal RNA;Ribosomes;Risk;RNA;Route;rRNA Genes;Sampling;selective expression;senescent cell;Sequence Analysis;Series;SF1;Simian virus 40;Site;South Asian;Stream;Structure;Sucrose;Techniques;telomere;Testing;Tissues;transcriptome sequencing;tumor;tumorigenesis;United States National Institutes of Health;Up-Regulation;Update;Valine;Variant;variant detection;whole genome;WI 38 cell;Work;Yeasts

PROJECT_TITLE: Placenta specific and ribosomal RNA genes: structure and function


NIH_SPENDING_CATS: Aging;Digestive Diseases;Genetics;Human Genome;Liver Disease;Regenerative Medicine

PROJECT_TERMS: age related;Age related pathologies;aged;Aging;aging process;ATAC-seq;Binding;Cells;ChIP-seq;Chromatin;cohort;Data;DNA;DNA Modification Process;Elderly;Enhancers;Epigenetic Process;Euchromatin;Event;EZH2 gene;Genetic Transcription;healthy aging;Heterochromatin;Histone Acetylation;histone methylation;Immune response;in vitro Model;insight;Investigation;late life;Liver;Liver Regeneration;Mediating;Metabolic;Methyltransferase;Modeling;Molecular;Multiomic Data;multiple omics;Mus;Natural regeneration;new therapeutic target;novel;Nuclear;Nuclear Lamina;old mice;Organ;paralogous gene;Phenotype;postmitotic;Process;regeneration following injury;Regulation;Role;Testing;Tissues;transcriptome sequencing;Work

PROJECT_TITLE: Epigenetic mechanisms of liver aging


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases

PI_NAMEs: WANG, WEIDONG  (contact)

PROJECT_TERMS: 19 year old;2019-nCoV;Address;Admission activity;Adult;aged;Aging;Animals;Archaea;Bacteria;Binding Proteins;Biogenesis;Biological Assay;bis-benzimidazole;Catalytic Domain;Cause of Death;Cell Line;Cells;Cessation of life;Chemicals;Collaborations;Communication;Complex;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 treatment;CRISPR/Cas technology;Data;Dengue;Development;DNA;DNA Binding;DNA metabolism;DNA Topoisomerases;drug candidate;Drug Screening;Drug Targeting;drug testing;Escherichia coli;Eukaryota;Family;FDA approved;FMR1 gene;Genetic Transcription;Goals;Guide RNA;Homologous Gene;Impairment;In Vitro;Individual;Infection;inhibitor;inhibitor therapy;Investigation;Knock-out;Legal patent;Link;link protein;Luciferases;Lung;Malignant Neoplasms;Manuscripts;Mouse Cell Line;mouse model;mRNA Translation;N-terminal;neurodevelopment;Nucleic Acids;Older Population;Outcome;pandemic disease;Paper;Patients;Persons;Pharmaceutical Preparations;prevent;Proliferating;Proteins;Proteomics;Publications;Publishing;remdesivir;Reporting;Retroviridae;Reverse Transcription Inhibition;RNA;RNA Binding;RNA metabolism;RNA replication;RNA Viruses;RNA-Binding Proteins;RNA-Directed DNA Polymerase;RNA-Directed RNA Polymerase;SARS coronavirus;Testing;Time;Topoisomerase;Topoisomerase Inhibitors;Translations;Viral;Viral Proteins;viral RNA;Virus Replication;web site;Work;ZIKA

PROJECT_TITLE: Investigation of whether Topoisomerase 3b can be a drug target for SARS-CoV-2 and other positive-strand RNA virus; and development of such a drug


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Genetics;Hematology;Primary Immunodeficiencies;Rare Diseases;Women's Health Research

PROJECT_TERMS: age acceleration;Aging;aging process;aging related disease;Atrophic condition of skin;BACH1 gene;Bilateral;Binding;Bone marrow failure;BRCA1 gene;BRCA2 gene;cancer risk;Cancer-Predisposing Gene;Catalytic Domain;Cataract;CDC45L gene;Cell Nucleus;Cells;Characteristics;Chromatin;Collaborations;Complement;Complex;Congenital Abnormality;Core Protein;crosslink;Cruciform DNA;Data;Defect;Diabetes Mellitus;Disease;DNA;DNA Binding;DNA biosynthesis;DNA Crosslinking;DNA Damage;DNA Interstrand Crosslinking;DNA Repair;DNA replication fork;DNA Structure;FANCB;FANCD2 protein;Fanconi Anemia Complementation Group A Protein;Fanconi Anemia pathway;Fanconi anemia protein;Fanconi's Anemia;Frequencies;Gene Conversion;Genes;Genome;genome integrity;Genome Stability;Genomics;Goals;helicase;Hereditary Disease;Histone Fold;homologous recombination;Human;In Situ;in vitro activity;in vivo;Lesion;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mitomycin C;Modeling;Modification;Monoubiquitination;Mutate;Names;new therapeutic target;Normal Cell;novel;novel therapeutic intervention;Nuclear;Nuclear Protein;Orthologous Gene;Osteopenia;Osteoporosis;PALB2 gene;Paper;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Phosphorylation;Play;Predisposition;premature;Premature aging syndrome;Premature Ovarian Failure;protein function;Proteins;Publications;Reaction;recruit;reduced muscle mass;replication stress;Reporting;Resistance;response;Role;Route;Signal Transduction;Spottings;Structure;Tissues;Transducers;Ubiquitin;ubiquitin ligase;Work;xeroderma pigmentosum group A complementing protein;Yeasts

PROJECT_TITLE: Investigate the DNA damage response pathway of Fanconi anemia and BRCA proteins


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

PROJECT_TERMS: Adult;Affect;Animals;Anxiety;Archaea;autism spectrum disorder;Bacteria;behavioral phenotyping;Binding;Biochemical;Biogenesis;Biological Assay;Brain;Cell Nucleus;Cells;Collaborations;Communication;Complex;conditioned fear;CRISPR/Cas technology;crosslink;crosslinking and immunoprecipitation sequencing;Cytoplasm;Data;Defect;Development;Disease;DNA;DNA metabolism;DNA Repair;DNA Topoisomerases;DNA Transposable Elements;dopaminergic neuron;Drosophila genus;Enzymes;Eukaryota;Evolution;Exhibits;Eye;fly;FMR1 gene;Focal Adhesion Kinase 1;Fragile X Syndrome;Fright;Functional disorder;Gene Silencing;Genes;Genetic study;Genetic Transcription;Goals;helicase;Heterochromatin;Hippocampus;Human;Human Genetics;Immunoprecipitation;Impaired cognition;Impairment;inhibitor;Intellectual functioning disability;Journals;Knock-out;Knockout Mice;Learning;Life;life span;Ligase;Link;Longevity;Manuscripts;Memory;Mental disorders;Mental Health;Messenger RNA;Metabolism;Modeling;mRNA Expression;mRNA Translation;Mus;mutant;Mutant Strains Mice;Mutation;Nature;neurodevelopment;neurogenesis;Neurology;Neuromuscular Junction;Neurons;Neurosciences;nuclease;Oocytes;overexpression;paralogous gene;Pathogenesis;Pathway interactions;Patients;Penetrance;Pharmaceutical Preparations;Phenotype;Point Mutation;Polymerase;Polyribosomes;Process;protein p68;Proteins;Psyche structure;PTK2 gene;Publishing;Reaction;repaired;Reporting;Research;response;RNA;RNA Binding;RNA Interference;RNA metabolism;RNA Recognition Motif;Schizophrenia;Single Nucleotide Polymorphism;Small Interfering RNA;Social Interaction;Stress;stress granule;Synapses;Synaptic plasticity;Synaptic Transmission;synaptogenesis;System;telomere;Testing;Topoisomerase;Transgenic Organisms;Translations;Work;Yeasts

PROJECT_TITLE: An RNA topoisomerase complex interacts with Fragile X syndrome protein to promote neurodevelopment and maintain normal life-span


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PROJECT_TERMS: 2019-nCoV;Acceleration;Affect;age related;Aging;Alzheimer's Disease;Alzheimer's disease patient;Animal Model;Animals;Aubergine;Behavior;Binding;Biochemical;Biogenesis;biological adaptation to stress;Biological Assay;Brain;Cell Death;Cell Line;Cells;Cognition Disorders;Collaborations;Complex;COVID-19;Cytoplasmic Granules;Data;Defect;Dissociation;DNA;DNA Transposable Elements;dominant genetic mutation;Drosophila genus;Drug Targeting;druggable target;Eukaryota;Exhibits;Eye;Eye Development;fly;FMR1 gene;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Genes;Genetic;Genetic Transcription;Goals;Hela Cells;Heterochromatin;Heterozygote;Human;Inflammation;inhibitor;Knockout Mice;life span;Link;Mammalian Cell;Mental disorders;Messenger RNA;misfolded protein;Modeling;Modification;mouse model;mRNA Transcript Degradation;mRNA Translation;Mus;mutant;Mutation;Nerve Degeneration;Nervous System Disorder;Neurologic;neurotoxicity;Optic Nerve;Ovary;pandemic disease;Pathogenicity;Pathologic;Pathway interactions;Phenotype;Phosphotransferases;piRNA;Play;Polyribosomes;protein TDP-43;Proteins;Reporter;Research Project Grants;RNA;RNA Viruses;RNA-Binding Proteins;RNA-Induced Silencing Complex;Role;Science;Secondary to;Stress;stress granule;stress reduction;synaptogenesis;tau mutation;tau Proteins;Tauopathies;therapeutic target;Topoisomerase;Topoisomerase Inhibitors;Toxic effect;Transcriptional Silencer Elements;transcriptome sequencing;Update;Variant;Wing;Work

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Investigating the roles of Topoisomerase 3b-TDRD3 complex in neurodegeneration and Alzheimer's disease


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Genetics;Machine Learning and Artificial Intelligence;Nanotechnology

PI_NAMEs: MARAGKAKIS, MANOLIS  (contact)

PROJECT_TERMS: Aging;aging related disease;animal tissue;Biological;Biological Process;Cell Physiology;cell type;Cells;Cellular Stress;Complex;Computer Analysis;Development;Disease;Encapsulated;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Goals;high dimensionality;Homeostasis;Lead;Machine Learning;Malignant Neoplasms;Mediating;Messenger RNA;Modeling;mRNA Decay;nanopore;Nerve Degeneration;Pathway interactions;Phase;Physiology;Post-Transcriptional Regulation;Post-Transcriptional RNA Processing;posttranscriptional;Process;programs;Property;Protein Isoforms;Protocols documentation;Ribosomes;RNA;RNA metabolism;RNA Probes;Signal Transduction;Tissues;tool;Work

PROJECT_TITLE: RNA dynamics and co-translational decay in aging and aging-related disease


PROJECT_TERMS: age-related disease;Biology;Blood;Body Weight;Bone Marrow;Bone marrow failure;Bone Marrow Transplantation;Cell Physiology;Cells;Consumption;Defect;Disease;DNA Damage;DNA Repair;Dyskeratosis Congenita;Enterocolitis;Equilibrium;Exhibits;Fertility;Fibroblasts;fitness;Functional disorder;gastrointestinal;Generations;Genes;Genomic Instability;Germ Lines;Geroscience;hallmarks of aging;Health;healthspan;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Human;Impairment;improved;in vivo;Inherited;Intervention;Journals;Knockout Mice;Length;Life;Link;Liver diseases;Lymphoid;Malignant Neoplasms;Mediating;Metabolism;metabolome;Mitochondria;mitochondrial dysfunction;Modeling;mortality;Mouse Strains;Myelogenous;Nicotinamide adenine dinucleotide;nicotinamide-beta-riboside;oral supplementation;Oxidation-Reduction;Pathogenesis;Pathology;Patients;peer;Pharmacological Treatment;Phenotype;Premature aging syndrome;Prevalence;Production;Publishing;Pulmonary Fibrosis;RNA-Directed DNA Polymerase;SIRT1 gene;Supplementation;Syndrome;systemic inflammatory response;Telomerase;telomere;telomere loss;Telomere Maintenance;Telomere Shortening;therapeutic development;Therapeutic Intervention;Tissues;treatment strategy;Work

PROJECT_TITLE: Assessing therapeutic intervention of short telomere syndromes


NIH_SPENDING_CATS: Aging;Genetics;Human Genome

PROJECT_TERMS: adduct;Aging;base;Basic Science;Binding Proteins;Biochemical;Bypass;Clinical;clinically relevant;cohort;Computer Analysis;Computer software;Data;Disease;DNA;DNA biosynthesis;DNA Structure;Etiology;G-Quartets;Genetic;Genetic Diseases;genetic risk factor;genome analysis;Genomic Instability;Genomics;Guanine;helicase;Heritability;human disease;In Vitro;Malignant Neoplasms;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial genome;Molecular;Mutagenesis;Mutation;Nucleotides;oxidative DNA damage;Point Mutation;Polymerase;Population Database;Recombinant DNA;Recombinant Proteins;reconstitution;Risk;Role;Site;Source;Structure;System;trait;Variant

PROJECT_TITLE: G-quadruplexes (G4) are potential DNA roadblocks that perturb mitochondrial replication machinery and pose a clinically relevant source of mitochondrial DNA mutation and instability


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

PROJECT_TERMS: Acute;age related neurodegeneration;age-related disease;Aging;Alzheimer's Disease;Caenorhabditis elegans;Cellular Assay;Cellular Stress;Chronic;Disease;DNA;DNA Damage;DNA Repair;DNA Repair Disorder;Functional disorder;Goals;Human;Mitochondria;mouse model;Nematoda;Nerve Degeneration;Neurodegenerative Disorders;novel therapeutic intervention;oxidative DNA damage;Play;Research Project Grants;response;Role;System;theories;Work

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT:  DNA repair dysfunction in neurodegeneration and Alzheimer's Disease


PROJECT_TERMS: age related;Aging;aging related;Biochemical;Biochemical Process;Cancerous;Cells;Characteristics;Code;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Structure;Double Strand Break Repair;Enzymes;Genes;Genetic;Genome;Genome Stability;Genomic Instability;helicase;homologous recombination;Human;Life;Light;Malignant Neoplasms;member;Mendelian disorder;Metabolic Pathway;Molecular;Mutate;Mutation;Nonhomologous DNA End Joining;Pathway interactions;Patients;Play;Premature aging syndrome;prevent;Process;protein function;Proteins;RECQL gene;RECQL4 gene;RECQL5 gene;Research;Role;Syndrome;Time

PROJECT_TITLE: Function of RecQ helicases in genome stability


NIH_SPENDING_CATS: Aging;Genetics;Rare Diseases

PROJECT_TERMS: Age;Age of Onset;age-related disease;Attention;Binding;Biochemical;Biological;Biological Models;Biological Process;biological systems;cancer predisposition;Cell Physiology;Cells;Chromosomal Instability;Chromosomal Stability;Chromosome Segregation;Complex;Diagnosis;Disease;disease phenotype;DNA;DNA biosynthesis;DNA Damage;DNA Maintenance;DNA metabolism;DNA Repair;DNA replication fork;DNA Structure;Elements;Enzymes;Exonuclease;Family;Functional disorder;gene product;Genes;Genetic;Genetic Models;Genetic Recombination;Genetic Transcription;genome integrity;Genome Stability;Genomic DNA;Genomic Instability;Goals;helicase;Homeostasis;Human;human disease;human DNA;Hydrolysis;in vivo;interest;Kinetics;Maintenance;Malignant Neoplasms;Mismatch Repair;Mitotic Recombination;Molecular;Molecular Motors;Mutation;Nuclear Proteins;nuclease;Nucleic Acids;nucleoside triphosphate;Pathway interactions;Play;preference;Premature aging syndrome;preservation;prevent;Prevention;Property;Protein Biochemistry;Proteins;Regulation;response;Role;Rothmund-Thomson syndrome;RTH-1 Nuclease;Single-Stranded DNA;Structure;System;Time;Werner Syndrome;Work;WRN gene

PROJECT_TITLE: Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability


PI_NAMEs: SEIDMAN, MICHAEL  (contact)

PROJECT_TERMS: Address;Aging;aging population;Antigens;Archaea;B Cell Proliferation;Binding;biological adaptation to stress;Biological Models;Cell Differentiation process;Cell Separation;Cells;chromatin remodeling;Chromatin Structure;crosslink;Defect;Detection;Development;Distal;DNA;DNA biosynthesis;DNA Crosslinking;DNA Damage;DNA fiber assay;DNA replication fork;DNA Structure;Elements;Euchromatin;Event;Exposure to;Failure;FANCD2 protein;Fanconi Anemia pathway;Fanconi anemia protein;Fanconi's Anemia;Fiber;Formaldehyde;Heterochromatin;in utero;Individual;Ionizing radiation;Location;Metabolism;Microscope;Neoplasms;novel;novel strategies;Nucleotides;Organ;Pathway interactions;Pattern;Postpartum Period;Premature aging syndrome;Preparation;Procedures;Process;Property;protein complex;Proteins;Quantum Dots;repaired;replication stress;response;Side;Site;Slide;Source;Stress;Tissues;translocase

PROJECT_TITLE: Repair of localized DNA damage


PROJECT_TERMS: Alkylating Agents;Basic Science;Biological;Biological Models;cancer cell;cancer therapy;Cell Line;Cell Physiology;Cells;chemotherapy;Chickens;Chromosomal Stability;clinically relevant;Complement;Critical Pathways;Diagnosis;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA Structure;Embryo;Evolution;Fanconi's Anemia;Fibroblasts;G-Quartets;Genetic;Genetic Diseases;Genetic Models;Genome;Genome Stability;Genomic Instability;Genotype;helicase;Helicase Gene;Homeostasis;Human;Human Cell Line;Human Genetics;in vivo;Individual;Inhibition of Cell Proliferation;insight;Knockout Mice;Link;Maintenance;Malignant Neoplasms;Molecular;Mus;mutant;Mutation;Normal Cell;novel;Orthologous Gene;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Premature aging syndrome;Radiation;repair function;repaired;replication stress;Resistance;RNA Interference;Role;small molecule;Stress;Structure;System;tumor;Werner Syndrome;Work;Yeasts

PROJECT_TITLE: Model Genetic Systems to Study DNA Repair


PROJECT_TERMS: BACH1 gene;Binding;Biochemical;Biological;BRCA1 gene;Chromosomal Instability;Clinical;Complement;crosslink;Data;Disease;DNA;DNA biosynthesis;DNA Damage;DNA metabolism;DNA Repair;DNA replication fork;DNA Structure;Double Strand Break Repair;early onset;Fanconi Anemia pathway;Fanconi's Anemia;Genetic;helicase;homologous recombination;insight;Length;Link;Malignant Breast Neoplasm;Mismatch Repair;Molecular;Mutate;Mutation;novel;Patients;Phenotype;Play;protein complex;Proteins;Recombinants;repaired;replication stress;response;Role;SS DNA BP;Substrate Specificity;Tail;Variant;Vertebral column;Work

PROJECT_TITLE: Fanconi Anemia Pathway


NIH_SPENDING_CATS: Aging;Genetics

PROJECT_TERMS: Address;Affect;age related;age-related disease;Aging;Apoptosis;Binding;Biochemical;cancer cell;Cell Aging;Cell division;Cell Proliferation;Cells;Chromosomal Rearrangement;Chromosome Fragility;Chromosomes;Complex;Cytosine;Defect;Disparity;DNA;DNA biosynthesis;DNA Damage;DNA strand break;Equilibrium;Excision;Functional disorder;G-Quartets;Genes;Genetic;Genetic Transcription;Genome;genome integrity;Genomic Instability;Guanine;homologous recombination;Human;Hybrids;insight;Length;Link;Malignant Neoplasms;Mediating;Molecular;novel;nuclease;Nucleic Acids;Nucleotides;Pathway interactions;Phenotype;preservation;prevent;Process;Protein Binding Domain;Proteomics;Publishing;Regulation;replication stress;Research;Resolution;response;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;Role;screening;spot 14 protein;Structure;Telomerase;telomere;telomere loss;Telomere Maintenance;Telomere Shortening;Therapeutic;Transcript;trend;Variant;Work

PROJECT_TITLE: Resolution of telomeric nucleotide structure barriers by specific structure nucleases


PI_NAMEs: WENG, NAN-PING PETER (contact)

PROJECT_TERMS: Age;Aging;aging related;B-Lymphocytes;Blood;Blood Cells;CD8-Positive T-Lymphocytes;Cell Aging;Cell Cycle;Cell Cycle Progression;Cell division;Cell Physiology;Cell Senescence Induction;Cells;Cultured Cells;Elderly;Gene Expression;Gene Modified;Goals;Human;Immune;Immune response;in vivo;Individual;influenza virus vaccine;Length;Longitudinal cohort;Lymphocyte;Lymphocyte Function;Measurement;Measures;Methods;Molecular;monocyte;mouse model;Mus;Natural Killer Cells;Process;Proliferating;Records;Reporter;Role;single-cell RNA sequencing;T-Lymphocyte;Telomerase;telomere;Testing;transcriptome

PROJECT_TITLE: Role of Telomere and telomerase In Human Lymphocyte Function and Aging


PROJECT_TERMS: age related;age related changes;Aging;ATAC-seq;Binding Proteins;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Proliferation;Cells;ChIP-seq;Chromatin;comparative;differential expression;DNA Methylation;Gene Expression;Gene Expression Profiling;gene function;Genes;Genetic Transcription;genomic locus;Goals;homeodomain;Human;In Vitro;interest;knock-down;Lymphocyte;Measures;Memory;NR4A1 gene;older adult;overexpression;Play;Process;Proliferating;promoter;protein expression;Protein Isoforms;Proteins;Reporting;Role;single-cell RNA sequencing;T cell differentiation;T memory cell;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;terminally differentiated effector memory (TEM) T cells;Transcriptional Regulation;transcriptome;Up-Regulation

PROJECT_TITLE: Mechanisms Of Age-related Changes in Transcriptional Regulation in lymphocytes


PI_NAMEs: EGAN, JOSEPHINE  (contact)

PROJECT_TERMS: age related;Aging;Asthma;beta catenin;Bone Marrow;Brain;Cells;Chronic;Cues;Development;Distal;Environment;Event;Generations;Genes;Genetic;Goals;gut microbiota;Human Pathology;Immune;insight;Interleukin-13;Interleukin-4;Maintenance;Mature T-Lymphocyte;Molecular;Molecular Probes;Mus;Mutant Strains Mice;Neurologic;Peripheral;Proteins;Regulation;response;Role;Signal Transduction;Signaling Molecule;systemic inflammatory response;T-Cell Development;T-Cell Receptor;T-Lymphocyte;TCF Transcription Factor;thymocyte;Thymus Gland;transcription factor;Transgenic Mice;Work;γδ T cells

PROJECT_TITLE: Development and function of conventional and innate T cells


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Microbiome;Women's Health Research

PROJECT_TERMS: Ablation;adaptive immunity;Affect;aged;Aging;aging related;aging related disease;anti-PD1 therapy;Antibodies;Antigens;B-Lymphocytes;Blood;breast cancer metastasis;carcinogenesis;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;checkpoint inhibition;Circulation;Clinical;Collaborations;Collection;COVID-19 pandemic;COVID-19 pandemic effects;CXCR6 gene;Data;Disease Outcome;ecto-nucleotidase;Effector Cell;Elderly;Event;experimental study;Growth;gut dysbiosis;gut microbiota;Human;Immune;Immune response;Immunology;immunosenescence;Immunotherapy;improved;Inflammatory;Insulin Resistance;Interruption;Leaky Gut;Link;Longitudinal Studies;Macaca;Macrophage;male;Malignant Breast Neoplasm;Malignant Neoplasms;Metabolic;Metabolic syndrome;Metastasis Induction;microbiome sequencing;microbiota;Midlife women;monocyte;Mus;Nature;novel;old mice;Oral;Outcome;Pathogenicity;Pathology;Pathway interactions;Play;Publications;recruit;Regulatory T-Lymphocyte;Reporting;Role;Safety;Sampling;Science;Solid Neoplasm;Supplementation;systemic inflammatory response;Testing;therapeutic development;Time;tumor;Tumor Expansion;tumor growth;tumor progression;Tumor Promotion;Tumor Tissue

PROJECT_TITLE: Immunology of aging and immunotherapy of aging-associated diseases


PROJECT_TERMS: 2019-nCoV;Biochemical;Cells;combat;Complex;Coronavirus;COVID-19;Exonuclease;G-Quartets;Genetic Transcription;Genetic Variation;Genome;Genomics;helicase;In Vitro;in vivo;Individual;inhibitor;Libraries;Life Cycle Stages;Maps;Modeling;Molecular;Murine hepatitis virus;Mus;Mutagenesis;Mutation;novel coronavirus;nucleic acid structure;pharmacologic;Point Mutation;Pre-Clinical Model;Proteins;RNA;RNA Helicase;RNA-Directed RNA Polymerase;Role;SARS-CoV-2 genome;stem;Structure;symptom treatment;transmission process;Viral;Virulence;Virulent;Virus

PROJECT_TITLE: COVID-19 Nsp13 Helicase Analysis: Assessment of Unwinding SARS-CoV-2 Mutagenic RNA Secondary Structures and Pharmacological Modulation in a Preclinical Model


NIH_SPENDING_CATS: Aging;Genetics;Nutrition

PROJECT_TERMS: Age;age related;Aging;Cells;Chromosomal Stability;dietary;dietary manipulation;disease phenotype;DNA Damage;Environment;experience;Exposure to;Foundations;Functional disorder;Genome Stability;helicase;Homologous Gene;Human;in vivo;innovation;Knockout Mice;Knowledge;Laboratories;Lesion;Longevity;Mammals;Modeling;molecular pathology;mouse model;Mus;mutant;novel;Organ;Pathway interactions;Phenotype;Principal Investigator;RECQL gene;replication stress;Research;response;Rodent Model;Role;Stress;Tissues

PROJECT_TITLE: NIA Inter-Lab Project: Analyses of Age-Related Phenotypes Displayed by RECQL1 Deficiency in a Rodent Model


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Nanotechnology;Neurodegenerative;Neurosciences

PI_NAMEs: SEN, PAYEL  (contact)

PROJECT_TERMS: Adopted;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;analysis pipeline;Baltimore;Cell Nucleus;Cells;Clinical;Complementary DNA;Custom;Data Analyses;Data Set;Detection;Development;Disease Progression;early detection biomarkers;Etiology;Excision;experimental study;Future;Genes;genetic variant;Genomics;Incidence;Individual;insight;Longitudinal Studies;Messenger RNA;Methodology;Methods;Molecular;Monitor;multimodality;nanopore;novel;Outcome;Participant;Pathogenesis;Pattern;Peripheral Blood Mononuclear Cell;Population;Prediction of Response to Therapy;Process;Protein Isoforms;Research;Research Project Grants;RNA;Role;single nucleus RNA-sequencing;targeted treatment;Technology;Therapeutic Intervention;Transcript;transcriptomics

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT - Interrogating RNA Isoform Diversity and Function in Alzheimer's Disease by Long-Read Sequencing


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: 3-Dimensional;Age;age related;age related changes;aged;Aging;aging brain;aging mechanism;Alzheimer's Disease;Animals;Astrocytes;barrier to testing;beta-Galactosidase;Blood - brain barrier anatomy;Brain;brain tissue;cell type;Cells;Coculture Techniques;Cognitive;drug testing;drug use screening;Electrophysiology (science);Epigenetic Process;functional improvement;Galectin 3;Glial Fibrillary Acidic Protein;Goals;In Vitro;insight;Intervention;Link;Microglia;Modeling;Molecular;molecular marker;multiple omics;Nerve Degeneration;Neurologic;Neurons;old mice;Oligodendroglia;Organoids;Output;preservation;Research Project Grants;Resolution;senescence;spatiotemporal;tau-1;Testing;Therapeutic

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT - Exploring neuron-microglia-astrocyte-oligodendrocyte interactions during aging using primary cultures and brain-mimicking and age-relevant organoid models


NIH_SPENDING_CATS: Aging

PI_NAMEs: GOROSPE, MYRIAM  (contact)

PROJECT_TERMS: Affect;Age;age-related disease;aging related;Autophagocytosis;Binding Proteins;Biology;Coat Protein Complex I;cytokine;Defect;Exhibits;Fibroblasts;Genes;Golgi Apparatus;Heparan Sulfate Biosynthesis;Impairment;Inflammatory;Intracellular Transport;member;Modeling;Multiple Abnormalities;Organelles;Phenotype;Production;Proliferating;Protein Biosynthesis;Proteins;Proteomics;senescence;senescent cell;Structure;trafficking;uptake;Vesicle

PROJECT_TITLE: Alteration in function of the Golgi complex in senescent cells


PROJECT_TERMS: Accounting;Action Potentials;Adverse effects;Affect;analog;Arrhythmia;Behavior;cancer cell;cancer therapy;cancer type;Cardiac;Cardiac pacemaker;Cardiotoxicity;Cell Cycle;Cells;Clinical;Confocal Microscopy;Coupled;effective therapy;Endothelial Growth Factors Receptor;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Fire - disasters;Gastrointestinal Stromal Tumors;Goals;Growth Factor Receptors;Heart;heart function;improved outcome;inhibitor;Investigation;KDR gene;kinase inhibitor;Length;Link;Malignant Neoplasms;Mediating;Neoplasm Metastasis;nodal myocyte;Oryctolagus cuniculus;Pacemakers;Patch-Clamp Techniques;Pathway interactions;Patient-Focused Outcomes;Perforation;Periodicity;Pharmaceutical Preparations;Phosphatidylinositols;Phospholipase C;Phosphotransferases;pre-clinical;Protein Isoforms;Protein Kinase C;receptor;Receptor Activation;Receptor Protein-Tyrosine Kinases;Regulation;Role;Sarcoplasmic Reticulum;Sick Sinus Syndrome;side effect;Sinoatrial Node;Sinus Bradycardia;System;Systemic Mastocytosis;targeted cancer therapy;Testing;tumor;tumor microenvironment;tumor progression;Tyrosine Kinase Inhibitor;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors

PROJECT_TITLE: Tyrosine kinase receptors (VEGFR and EGFR) regulate normal automaticity of heart pacemaker, the sinoatrial node.


PROJECT_TERMS: Acceleration;Adult;African American;Age;Aging;Area;arterial stiffness;Blood Pressure;blood pressure regulation;Capillary Endothelial Cell;Cardiovascular system;cell type;Cells;Clinical;Data Set;Diabetes Mellitus;diabetic;Diastolic blood pressure;Endothelial Cells;Erythrocytes;European;European ancestry;fasting plasma glucose;Femur;Follow-Up Studies;G6PD gene;Genes;Genetic;genetic variant;genome wide association study;genome-wide analysis;Genomics;Glucose;Heritability;Human;Hypertension;indexing;Individual;inflammatory marker;Interleukin-6;Kidney;kidney cell;kidney cortex;Linkage Disequilibrium;Myofibroblast;non-diabetic;Odds Ratio;Physiologic pulse;Plasma;polygenic risk score;Population;Precision Health;predictive modeling;Research;Risk;ROC Curve;Role;Sampling;Sardinia;secondary analysis;Single Nucleotide Polymorphism;Solid;trait;Tubular formation

PROJECT_TITLE: Genome-wide Association Study of Cardiovascular Traits in 6142 Sardinians


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Physical Activity;Prevention

PROJECT_TERMS: Aerobic;Aerobic Exercise;Age;age effect;age group;age related;age related decline;age-related disease;Aging;American;Automobile Driving;Baltimore;Biological;Blood;Cardiac;Cardiac Output;Cardiovascular Diseases;cardiovascular disorder prevention;Cardiovascular Physiology;Cardiovascular system;Clinical;Communities;conditioning;Data;design;Detection;Disease;EFRAC;Elderly;Environment;Equation;Ergometry;Exercise;exhaustion;follow-up;Future;Gated Blood-Pool Imaging;Gender;Genetic;Heart;Heart failure;Heart Rate;Homeostasis;Individual;Intervention;Journals;Left;Life;Life Style;Linear Regressions;longitudinal analysis;Longitudinal Studies;male;Measurement;Measures;men;Modeling;Muscle;older patient;Older Population;Oxygen;Oxygen Consumption;Participant;Performance;Peripheral;Persons;Physical Fitness;Physiology;Play;preservation;pressure;Prevention strategy;Publishing;Radionuclide Ventriculography;rate of change;Rest;Role;Sampling;Scanning;sex;Structure;Time;Training;uptake;Variant;Ventricular;VO2max;volunteer;Woman;women subjects;Work;Workload

PROJECT_TITLE: Effects Of Age And Conditioning Status On Rest And Exercise Cardiac Performance


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Heart Disease;Hypertension;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: Age;age related;age related changes;Aging;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Analysis of Variance;Aorta;arterial stiffness;behavior test;Blood Pressure;Blood Vessels;Brain;Breeding;Cardiac;cardiac aging;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Clinical;Collagen;Consumption;Dahl Hypertensive Rats;Data Analyses;design;Development;Diet;Echocardiography;Elastin;Elderly;epidemiology study;Exhibits;experimental study;Fibrosis;GDF15 gene;General Population;Genes;hemodynamics;Hippocampus;Histocytochemistry;Hypertension;Impaired cognition;Impairment;indexing;Inflammation;Inflammatory;inhibitor;Left ventricular structure;Life;Linear Regressions;male;marinobufagenin;Measurement;Measures;Memory;Memory Loss;Microvascular Dysfunction;Modeling;morris water maze;mRNA Expression;Na(+)-K(+)-Exchanging ATPase;Nerve Degeneration;Physiologic pulse;Process;Rattus;Risk Factors;senescence;Sodium Chloride;spatial memory;Sprague-Dawley Rats;Testing;TGFB1 gene;Thick;TP53 gene;Vascular Dementia;Weight

PROJECT_TITLE: Exploring the involvement of Na pump inhibitor marinobufagenin in the interactions between age-associated vascular and neurodegenerative processes in cognitive impairment and Alzheimer's disease


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cardiovascular;Clinical Research;Genetics;Heart Disease;Obesity;Physical Activity;Prevention

PROJECT_TERMS: Acceleration;ACE2;Aerobic;Aerobic Exercise;Age;age difference;age effect;age related;age related changes;age related decline;Age Years;Aging;Ankle;Aorta;arterial stiffness;Automobile Driving;Baltimore;biological age;Biomedical Engineering;Blood Pressure;Blood Vessels;Body Size;Body System;Bone Density;calcification;Calibration;Cardiac;cardiac aging;Cardiac Output;cardioprotection;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Carotid Arteries;Cells;Central obesity;Characteristics;Clinical;cognitive function;cohort;Collaborations;Communities;comorbidity;Complex;Computer software;Coronary;coronary calcium scoring;Coupling;COVID-19 mortality;Data;design;Deterioration;Disease;Doppler Echocardiography;Echocardiography;Elderly;electric impedance;Endothelium;Environment;Erythropoietin;Event;Exercise;Fatty acid glycerol esters;Fibrosis;follow-up;frailty;Functional disorder;functional status;Future;Genes;Genetic;Genetic Determinism;genetic element;Genome;Geometry;Health;healthspan;Heart;Heart failure;heart function;Human;Hypothyroidism;indexing;Individual;Inflammation;Insulin-Like Growth Factor I;International;intimal medial thickening;Intramural Research Program;Laboratories;Left ventricular structure;Life;Life Style;Link;Longitudinal Studies;Magnetic Resonance Imaging;mathematical analysis;Measurement;Measures;Mechanics;Medial;Mediating;Mission;mitochondrial dysfunction;Modification;Muscle;Myocardial;Myocarditis;Nature;neglect;novel;Obesity;older patient;outcome prediction;Oxygen;Oxygen Consumption;Paper;Participant;Pattern;Performance;Peripheral;Peripheral arterial disease;Persons;Phenotype;Physical Fitness;Physiological;Play;Population;Postdoctoral Fellow;preservation;pressure;Prevention;Prevention strategy;Production;programs;Property;protein aminoacid sequence;proteostasis loss;Publishing;rate of aging;recruit;Reporting;Research;Research Project Grants;Risk Factors;Role;Sampling;Sardinia;Signal Transduction;Structure;subcutaneous;Testing;Thick;Tissues;tonometry;tool;Training;trait;translational study;Triglycerides;uptake;validation studies;Ventricular;Visceral;Visit;Vitamin D;VO2max;Work

PROJECT_TITLE: Age Associated Changes In Structural And Functional Cardio-Vascular  Properties


PROJECT_TERMS: age effect;age related;Aging;Agonist;Atrial Natriuretic Factor;Binding;Blood Pressure;blood pressure control;blood pressure elevation;Blood Vessels;Cardiac;Cardiovascular system;cell age;Cells;Collagen;Cyclic GMP;Development;Down-Regulation;Elderly;Excretory function;Exhibits;experimental study;Fibrosis;Friend leukemia;Genes;Goals;Hypertension;hypertensives;Impairment;inhibitor;Intake;Investigation;Kidney;kidney fibrosis;Lead;male;marinobufagenin;Na(+)-K(+)-Exchanging ATPase;Natriuretic Peptides;normotensive;Nuclear;Pathogenesis;prevent;Production;Protein Isoforms;Rattus;Renal tubule structure;response;salt sensitive;Sarcolemma;Signal Transduction;Smooth Muscle Myocytes;Sodium;Sodium Chloride;Sprague-Dawley Rats;Testing;therapeutic target;transcription factor;Vascular Smooth Muscle;Vasoconstrictor Agents;Western Blotting

PROJECT_TITLE: Marinobufagenin as a therapeutic target


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease

PROJECT_TERMS: Address;Affect;aldehyde dehydrogenases;Area;Axon;Behavior;Behavior Control;Behavioral;Binding;Brain;Calcium;Calcium Signaling;Chloride Channels;Corpus striatum structure;Coupled;Crossbreeding;Cues;cytotoxic;designer receptors exclusively activated by designer drugs;Development;Dopamine;dopaminergic neuron;Etiology;Failure;Feedback;GABA-B Receptor;Genetic;genetic manipulation;Glutamates;Head;Image;Implant;in vivo;insight;Investigation;Knock-in Mouse;Knowledge;Learning;Light;light gated;Maps;Mediating;Memory;Methods;Molecular;Monitor;Motivation;Motor;motor control;motor learning;motor skill learning;Motor Skills;Movement;Mus;neuronal excitability;Neurons;Neurotransmitters;NMDA receptor A1;novel therapeutic intervention;optical fiber;optogenetics;Outcome;Parkinson Disease;pars compacta;Pathogenesis;Patients;Pattern;Performance;Physiological;Play;Population;Predisposition;presynaptic;Process;receptor;receptor expression;Regulation;Research;Resolution;response;Rewards;Role;selective expression;Sensory;Signal Transduction;Silicones;Slice;Source;Substantia nigra structure;Task Performances;Techniques;temporal measurement;Time;treadmill;two-photon;Viral Vector;virtual;Walking

PROJECT_TITLE: Function and Regulation of ALDH1A1-positive Nigrostriatal Dopaminergic Neurons in Motor Control and Parkinson's disease


NIH_SPENDING_CATS: Aging;Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Therapeutic Cannabinoid Research

PROJECT_TERMS: 2-arachidonylglycerol;Adult;Affect;Anabolism;anandamide;Animal Model;Astrocytes;Basal Ganglia;Behavior;behavior test;Behavioral;biological adaptation to stress;Brain;brain cell;Brain region;Breeding;Calcium;Cells;China;Chinese;Clustered Regularly Interspaced Short Palindromic Repeats;CNR1 gene;conditional knockout;Corpus striatum structure;Coupled;Data;Dendrites;Development;Disease;Dopamine;dopaminergic neuron;Dorsal;Drug usage;early onset;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Enzymes;experimental study;Fiber;Functional disorder;Genes;GTP-Binding Proteins;Homologous Gene;Hospitals;Human;Immune response;Impairment;improved;Inflammation;innovation;insight;knock-down;Knockout Mice;Learning;lipoprotein lipase;loss of function mutation;Mediating;Memory;Microglia;Midbrain structure;Motivation;Motor;motor control;motor learning;motor skill learning;Movement;Mus;Mutation;Neuromodulator;neuronal cell body;Neurons;neurotransmitter release;Parkinson Disease;pars compacta;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Performance;Photometry;Physiological Processes;Play;presynaptic;Presynaptic Terminals;prevent;Production;professor;receptor;Research;response;Rod;Role;Rotation;Signal Transduction;Substantia nigra structure;Technology;Testing;time use;transcriptome sequencing;transmission process;treatment strategy;Universities;Ventral Tegmental Area

PROJECT_TITLE: Function and Pathogenic Mechanism of endocannabinoid synthase DAGLB in Parkinson's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: COOKSON, MARK  (contact)

PROJECT_TERMS: Address;Age;age related neurodegeneration;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Biology;Cell Aging;cell type;Cells;Chromatin;cohort;Data;Dementia;Disease;DNA Methylation;donor stem cell;dopaminergic neuron;Enrollment;Environment;Environmental Exposure;epigenetic clock;epigenetic marker;Epigenetic Process;Event;experimental study;Gene Expression;Genes;Genetic;genetic makeup;genetic risk factor;genetic variant;Genetic Variation;Genome;genome editing;genome wide association study;genome-wide;genome-wide analysis;Human;Human Genetics;Individual;induced pluripotent stem cell;Inherited;Laboratories;large datasets;lifetime risk;Link;Linkage Disequilibrium;Maps;Measures;Mediating;Methylation;Microglia;Modification;Molecular;Neurodegenerative Disorders;Neurons;non-genetic;Output;Parkinson Disease;Peripheral Blood Mononuclear Cell;Phenotype;pluripotency;Population;Population Genetics;Productivity;Quality Control;Quantitative Trait Loci;Research Project Grants;Resources;Risk;Symptoms;System;Testing;trait;transcriptome sequencing;transcriptomics;Translations;Variant;whole genome

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT:  Genetic Variants Associated with Alzheimer's disease and Related Dementias


PI_NAMEs: SINGLETON, ANDREW  (contact)

PROJECT_TERMS: advanced analytics;Africa;Africa South of the Sahara;Aging;American;Base Pairing;Biological;Biological Assay;Brain;Brain region;brain tissue;Cataloging;Catalogs;Cells;Chromatin;Copy Number Polymorphism;Data;data integration;data management;Data Set;Disease;DNA Methylation;dopaminergic neuron;Epigenetic Process;epigenome;epigenome-wide association studies;exome sequencing;Foundations;Founder Effect;Genetic;Genetic Transcription;genetic variant;Genetic Variation;genome sequencing;genome wide association study;genome-wide;genomic variation;Genomics;Genotype;Geography;Goals;Haplotypes;Human;Human Genetics;Individual;induced pluripotent stem cell;interest;Linkage Disequilibrium;Methylation;Modification;Molecular;Pathway interactions;Pattern;Phase;Population;Quantitative Trait Loci;Regulation;Role;Sampling;Site;SNP genotyping;Structure;Tissues;trait;transcriptome sequencing;transcriptomics;Variant;whole genome;Work

PROJECT_TITLE: Characterization of Normal Genomic Variability


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Prevention;Rare Diseases

PI_NAMEs: TRAYNOR, BRYAN  (contact)

PROJECT_TERMS: Accounting;Adolescent;Affect;Age;age related decline;Aging;Alzheimer's Disease;American;Amyotrophic Lateral Sclerosis;Base Pairing;Bioinformatics;C9ORF72;Cholesterol;Chromosome 9;Clinical;clinical diagnosis;clinical subtypes;cohort;Collaborations;computing resources;Cost Savings;Data;Dementia;Development;Diagnosis;Disease;disease diagnosis;Disease Progression;DNA;effective therapy;European;familial amyotrophic lateral sclerosis;Family;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;gain of function;gene discovery;gene-targeted therapy;Genes;Genetic;Genetic Predisposition to Disease;genome sequencing;genome wide association study;Genomics;Genotype;Health Care Costs;innovation;Italy;Journals;Laboratories;late life;Link;Machine Learning;Massachusetts;Medicine;Mendelian randomization;Mobility decline;Molecular;Motor;motor neuron degeneration;Mutation;Myasthenia Gravis;National Institute on Aging;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neurogenetics;Neuromuscular Diseases;Neurons;New England;next generation sequencing;novel therapeutics;Paper;Paralysed;Pathologic;Pathway Analysis;Pathway interactions;Patients;Population;Publications;Publishing;Recording of previous events;recruit;Research;Research Subjects;Respiratory Failure;Risk Factors;Role;Sampling;Technology;Therapeutic Agents;therapeutic development;therapeutic target;Time;United States National Institutes of Health;Universities;Western World;whole genome;Work

PROJECT_TITLE: Genetic etiology of Amyotrophic Lateral Sclerosis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

PROJECT_TERMS: Accounting;Affect;Age;ALS patients;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyotrophic Lateral Sclerosis;Base Pairing;C9ORF72;Chromosome 9;Clinical;clinical diagnosis;cohort;Cost Savings;Data;Dementia;Disease;disease diagnosis;DNA;effective therapy;Epidemiology;European;Family;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;gene-targeted therapy;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;Health Care Costs;innovation;Journals;Laboratories;late life;Link;Lobe;Medicine;Molecular;Mutation;National Institute on Aging;Nervous System Disorder;Neurodegenerative Disorders;neurogenetics;Neuromuscular Diseases;Neurons;New England;next generation sequencing;Paper;Paralysed;Pathogenesis;Pathologic;Patients;Population;Publications;Publishing;Recording of previous events;Research;Research Project Grants;Respiratory Failure;Technology;therapeutic target;Time;Ubiquitin;United States National Institutes of Health;Variant;Western World;whole genome;Work

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Genetic etiology of Fronto-Temporal Dementia, a dementia related to Alzheimer's disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Immunotherapy;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

PI_NAMEs: MASLIAH, ELIEZER  (contact)

PROJECT_TERMS: 2019-nCoV;3-Dimensional;adaptive immunity;Advanced Development;age effect;aged;Aging;aging population;aging process;alpha synuclein;Alpha-Synuclein transgenic mouse;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;Animal Model;Animals;Antibodies;Antigen-Presenting Cells;Antigens;Apolipoprotein E;Astrocytes;Astrocytosis;Behavioral;Binding;Brain;Candidate Disease Gene;CCL4 gene;CD3 Antigens;CD8-Positive T-Lymphocytes;Cell Aging;Cell model;Cell Nucleus;cell type;Cells;Chromatin;Collaborations;Combination immunotherapy;combinatorial;comparison control;conformer;CSF1 gene;CSF1R gene;CSF2 gene;cytokine;data integration;Dementia with Lewy Bodies;Dependovirus;Disease;DNA Damage;epigenomics;Exhibits;Experimental Animal Model;experimental study;extracellular;Functional disorder;Gene Expression Profile;Genes;genetic architecture;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genetic Transcription;Genetically Engineered Mouse;Germany;glial activation;Glial Fibrillary Acidic Protein;Gliosis;Glycoproteins;Goals;Human;human tissue;Hybrids;Immune;immune modulating agents;Immune system;Immunoglobulin G;Immunologic Receptors;immunomodulatory therapies;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vitro Model;in vivo Model;induced pluripotent stem cell;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;interest;Interferon Type II;Interleukin-6;Label;Laboratories;Lewy Body Disease;Link;Lipids;LRRK2 gene;Manuscripts;MAP Kinase Gene;Maps;Mediating;Mediator;member;Methods;Microglia;Modeling;Molecular;Molecular Profiling;Motor;motor deficit;Mouse Strains;Multiomic Data;multiple omics;Mus;Mutation;Natural Immunity;Nerve Degeneration;neurogenetics;Neuroimmune;Neuroimmune system;neuroinflammation;neuron loss;Neuronal Differentiation;Neurons;neuropathology;neurotoxic;NF-kappa B;novel;nuclear factors of activated T-cells;Nuclear Translocation;overexpression;p38 Mitogen Activated Protein Kinase;Paper;Parkinson Disease;Pathogenesis;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Play;Preparation;Production;promoter;protein aggregation;protein TDP-43;Proteins;proteostasis;Publishing;receptor;Regulatory Element;Reporter;Research;Resolution;response;risk variant;Role;Science;Serotyping;Signal Pathway;Signal Transduction;small hairpin RNA;small molecule;South Korea;Substantia nigra structure;Susceptibility Gene;Synapses;synuclein;synucleinopathy;System;T cell infiltration;T cell response;T-Cell Receptor;T-Lymphocyte;targeted treatment;tau Proteins;Testing;Therapeutic;therapeutic target;therapeutically effective;therapy development;TLR2 gene;Toll-like receptors;transcription factor;transcriptomics;Transgenic Mice;translational medicine;Translational Research

PROJECT_TITLE: Alzheimers Disease Project: Neuroimmune responses and therapeutics of alpha-synucleinopathies of the aging population


PROJECT_TERMS: Affect;Affinity;age related;AGFG1 gene;Astrocytes;Binding;Cells;Collaborations;Cryoelectron Microscopy;design;Goals;GTP Binding;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Inherited;Intracellular Membranes;Laboratories;LRRK2 gene;Lysosomes;Mus;Mutation;Parkinson Disease;Penetrance;Phosphorylation;Phosphotransferases;protein protein interaction;Proteins;recruit;Role;Signal Pathway;Stimulus;Structure;Work

PROJECT_TITLE: GTPase function of Leucine rich repeat kinase 2


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PROJECT_TERMS: Affect;alpha synuclein;Back;Brain;Collection;Dementia;Deposition;Disease;Disease Marker;Disease Progression;Evaluation;Functional disorder;Genes;Goals;Incidence;induced pluripotent stem cell;Lewy Bodies;Methodology;Mutation;Neurons;Parkinson Disease;Pathologic;Phosphorylation;Play;protein aggregation;Proteins;Resources;Role;screening;Structure;Techniques;Time;Tissues;Toxic effect;Work

PROJECT_TITLE: Alpha Synuclein, cellular dysfunction and Parkinson disease


PI_NAMEs: CAI, HUAIBIN  (contact)

PROJECT_TERMS: Affect;Aging;Anatomy;Attention;Autopsy;Behavioral;Brain;Classification;Compensation;Complex;Cues;design;Disease;Dopamine;dopaminergic neuron;Gene Expression Profile;Genetic Markers;Genetic Variation;Individual;innovation;insight;Investigation;Knowledge;Link;Memory;Midbrain structure;Molecular;Molecular Genetics;molecular marker;Motivation;Motor;motor control;motor skill learning;motor symptom;Movement;neuron loss;Neuronal Dysfunction;Neurons;neuroregulation;non-motor symptom;Parkinson Disease;pars compacta;Pathway interactions;Patients;Pattern;Play;presynaptic;Procedures;Regulation;Research;Research Personnel;response;reward processing;Rewards;Role;segregation;Sensory;single-cell RNA sequencing;SOX6 gene;Stimulus;Substantia nigra structure;Technology;Ventral Striatum;Ventral Tegmental Area

PROJECT_TITLE: Pathophysiological Study of ALDH1A1-negative Nigrostriatal Dopaminergic Neuron Subtypes in Parkinson's disease


NIH_SPENDING_CATS: Aging;Neurosciences

PROJECT_TERMS: Affect;Area;Axon;Binding;Calcium;Categories;comparison control;Control Groups;Corpus striatum structure;Dendrimers;Dendrites;Dopamine;dopaminergic neuron;Dorsal;Drops;Engineering;Exhibits;Feedback;Fiber;Functional disorder;GABA-B Receptor;Genetic;Genetically Engineered Mouse;Globus Pallidus;improved;insight;Learning;Light;LRRK2 gene;Monitor;motor control;motor learning;motor skill learning;Mus;nerve supply;Neurons;optogenetics;Parkinson Disease;pars compacta;Pathway interactions;Pattern;Photometry;Physiological;Play;Presynaptic Terminals;Process;protein biomarkers;Regulation;response;Role;Rotarod Performance Test;Signal Transduction;striosome;Structure;Substantia nigra structure;Techniques;Time;Training;Viral Vector

PROJECT_TITLE: Striosome Microcircuit Critical for Motor Skill Learning


PROJECT_TERMS: Adult;Age;Anabolism;Area;Brain;brain cell;Brain region;Corpus striatum structure;Crossbreeding;Dietary Supplementation;Dorsal;Equilibrium;Exhibits;experience;experimental study;Future;Gene Expression;Genetic;Globus Pallidus;Imaging Techniques;improved;Individual;insight;Investigation;Learning Difficulty;Mediating;Methods;Modeling;Modification;motor learning;motor skill learning;Motor Skills;mouse model;Movement;Mus;neuron development;neuron loss;Neurons;Opioid Receptor;optogenetics;Parkinson Disease;Pathogenesis;Pathway interactions;postnatal;postsynaptic;Rotarod Performance Test;single nucleus RNA-sequencing;Stains;striosome;Substantia nigra structure;Synapses;Techniques;Therapeutic;Tretinoin;Up-Regulation

PROJECT_TITLE: Alterations of Striatal Projection Neurons in Parkinson's disease