ORG_CITY: PITTSBURGH

PHR: Stroke is a devastating disorder and a leading cause of death and long-term disability in elderly veterans, as currently no therapy is available to alleviate post-stroke neurological deficits. The proposed study will explore bexarotene as a promising therapy for ischemic stroke. We will investigate whether bexarotene protects against ischemic brain injury and improves long-term neurological outcomes after experimental stroke in aged mice of both sexes. The studies proposed will also use state-of-the art approaches, comprehensive and long-term assessment of neurological functions, and aged subjects to gain novel mechanistic insights into the role of bexarotene in microglia and macrophage responses after ischemic stroke. This information will be valuable for future development of new stroke therapy for military men and women as well as elderly civilians.

PI_NAMEs: CHEN, JUN  (contact)

PROJECT_TERMS: Acute;Acute Brain Injuries;Adopted;aged;Aging;Agonist;angiogenesis;animal old age;Anti-Inflammatory Agents;Antineoplastic Agents;Apical;Arbitration;Attenuated;behavior test;Bexarotene;Biological;Brain;Brain Ischemia;brain repair;Caring;Cause of Death;Cells;central nervous system injury;Cerebral cortex;Cerebral Ischemia;Cerebrum;Chronic;clinical translation;Clinical Treatment;Clinical Trials;clinically relevant;Cognitive;conditional knockout;Data;Decision Trees;Deterioration;Development;Diagnosis;disability;Disease;Distal;Dose;Elderly;Electrophysiology (science);Equilibrium;Evolution;Exhibits;FDA approved;Foundations;Functional impairment;functional outcomes;Funding;Future;Gatekeeping;Genetic Transcription;Goals;gray matter;Guidelines;healing;Histologic;Hospitalization;Hyperactivity;Immune;immune function;Immune response;Immune system;Immunosuppression;Impairment;improved;In Vitro;in vitro testing;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury;insight;intraperitoneal;Ischemic Brain Injury;Ischemic Stroke;Knock-out;Knockout Mice;Left;Long term disability;long term recovery;Macrophage;mature animal;Measurement;Metabolism;Microglia;Middle Cerebral Artery Occlusion;military men;military women;Modeling;Molecular;monocyte;Mus;Nature;Nerve Fibers;Nervous System Physiology;Neuroglia;neuroinflammation;Neurologic Deficit;Neurological outcome;Neurons;neuroprotection;new therapeutic target;novel;old mice;Outcome;Oxidation-Reduction;Phagocytes;Phagocytosis;Pharmaceutical Preparations;Phenotype;Pilot Projects;Positioning Attribute;post stroke;PPAR gamma;pre-clinical;Primary Cell Cultures;primary outcome;Production;Proteins;receptor binding;Recovery;Recovery of Function;repaired;Research;Resolution;response;Role;RXR;Safety;sex;Solid;Stroke;stroke model;stroke outcome;stroke recovery;stroke therapy;Survivors;Tamoxifen;Testing;Therapeutic;Tissues;Titrations;tool;transcriptome;transcriptome sequencing;Veterans;white matter;young adult

PROJECT_TITLE: Activation of the RXR/PPARγ axis improves long-term outcomes after ischemic stroke in aged mice


ADMINISTERING_IC: HG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE New discoveries in genomics depend in large part upon the exploration of many large experimental datasets and diverse genome annotations. Researchers face fundamental analysis bottlenecks caused by the fact that existing “genome arithmetic” algorithms, software and data format are incapable of scaling to the size and complexity of modern genomics experiments. We therefore propose to develop innovative analysis techniques and data formats that will provide the genomics research community with scalable, reliable tools for exploring and interpreting tomorrow’s genomics experiments.

PI_NAMEs: QUINLAN, AARON R (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Address;Algorithmic Analysis;Algorithms;Arithmetic;base;Beds;Biological;Biological Assay;ChIP-seq;Chromatin;Chromosomes;Collaborations;Communities;Complement;complex data;Computer software;Creativeness;Custom;Data;data format;Data Set;data visualization;Detection;Development;Discipline;diverse data;DNA;DNA sequencing;empowerment;Exons;experience;experimental study;Face;file format;flexibility;Foundations;Future;Gene Expression;Genes;Genome;genome annotation;genome browser;genomic data;Genomics;Growth;improved;indexing;innovation;insight;large datasets;large scale data;Libraries;Measures;Methods;Microscope;Modernization;Noise;Nucleic Acids;operation;outreach;parallelization;Pattern;Performance;Programming Languages;Proteins;Quality Control;reference genome;Research;Research Personnel;Sampling;Sequence Alignment;Signal Transduction;single cell genomics;Spectrum Analysis;Speed;Statistical Data Interpretation;Structure;System;Techniques;Technology;Testing;Time;tool;user friendly software;Visualization;Visualization software

PROJECT_TITLE: New algorithms and tools for large-scale genomic analyses

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Overall Project Narrative The primary goal of the Cancer Center is to promote collaborative interactions across seven consortium institutions that will lead to new approaches to cancer prevention, diagnosis, and treatment. These advances will occur while also advancing the Center’s mission to reduce disparities and to train future leaders in cancer research.

PI_NAMEs: EBERT, BENJAMIN LEVINE (contact)

PROGRAM_OFFICER_NAME: PTAK, KRZYSZTOF

PROJECT_TERMS: Acceleration;Advanced Malignant Neoplasm;anti-cancer research;Appointment;Awareness;base;Basic Science;Behavioral;bench-to-bedside translation;Biological;Biology;Boston;Cancer Biology;cancer care;cancer cell;Cancer Center;cancer epidemiology;Cancer Etiology;cancer genetics;cancer health disparity;Cancer health equity;cancer immunotherapy;Cancer Patient;cancer prevention;cancer risk;care delivery;Catchment Area;Cell Therapy;Clinic;Clinical;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engagement;Comprehensive Cancer Center;convict;Dana-Farber Cancer Institute;Data Science;Development;Developmental Therapeutics Program;Diagnosis;disparity reduction;Dreams;Early Diagnosis;Education;Educational Activities;empowerment;Ensure;Environment;Equity;Faculty;first-in-human;Fostering;Funding;Future;Future Generations;General Hospitals;Genetic;Genetic Heterogeneity;Goals;Grant;Grooming;Health Sciences;high risk population;Hospitals;immune checkpoint blockade;improved;improved outcome;Individual;Inequity;Infrastructure;innovation;insight;Institution;inter-institutional;interdisciplinary approach;interdisciplinary collaboration;Investigation;Israel;Laboratories;Laboratory Finding;Leadership;Learning;leukemia;Lymphoma;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Massachusetts;Medical center;medical schools;Melanoma;member;Mentorship;Minority;Mission;Modeling;Molecular;Multiple Myeloma;neuro-oncology;new technology;novel;novel strategies;novel therapeutics;Oncogenic;operation;Outcome;Pathogenesis;Pathway interactions;patient population;Pediatric Hospitals;Phase;Phase III Clinical Trials;Population;Population Sciences;prevent;Prevention;Prevention strategy;Preventive;Primary Neoplasm;programs;Public Health Schools;Renal Carcinoma;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Risk Assessment;Risk Reduction;Schools;Science;Screening for cancer;Services;Societies;Specimen;Strategic Planning;Structure;synergism;Talents;therapy resistant;Training;Training and Education;Transcend;Translational Research;Treatment outcome;treatment strategy;tumor immunology;Underserved Population;Universities;Woman;Work

PROJECT_TITLE: Dana-Farber/Harvard Cancer Center

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: MH

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: Princeton

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE  Aggression is a social behavior that is vital for survival and reproduction. Though most mental health patients are not violent, pathological, high levels of aggression are common across mental health disorders that affect millions of Americans. In order to improve our ability to prevent and treat these disorders, this study will define the experience-dependent changes in neural circuits that generate persistent pathological aggression.

PI_NAMEs: GUTHMAN, EARTHA MAE (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Affect;Aggressive behavior;Algorithms;American;Animals;Behavior;behavior change;Behavioral;Bipolar Disorder;Brain;Calcium;Calcium Signaling;cell type;Color;Complement;Complex;Data;Detection;Development;Disease;Disinhibition;Electrophysiology (science);excitatory neuron;experience;experimental study;Exposure to;Fellowship;Female;Fiber;Future;Glutamates;Goals;Human;Hypothalamic structure;improved;in vivo;Individual;Influentials;inhibitory neuron;innovation;Life;Link;male;Maps;Measures;Medial;Mental disorders;Mental Health;mental set;Methods;Mus;neural;neural circuit;Neurons;Neurosciences;Neurosciences Research;novel;offspring;optogenetics;Output;Pathologic;Pathology;Pathway interactions;Patients;personalized medicine;Photometry;Physiology;Play;Population;Post-Traumatic Stress Disorders;postsynaptic;Posture;Preoptic Areas;prevent;Psychological reinforcement;Recording of previous events;Regulation;Relaxation;Reproduction;Resources;Risk;Role;Schizophrenia;sex;Site;Slice;social;Social Behavior;Social Interaction;social neuroscience;Source;Substance abuse problem;Synapses;System;Techniques;Territoriality;Testing;tool;Training;Treatment Protocols;unsupervised clustering;Update;Work

PROJECT_TITLE: Experience dependent regulation of subcortical neural circuits for aggression


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PHR: Project Narrative  Not applicable.

PI_NAMEs: GOFF, DEBORAH J (contact)

PROJECT_TERMS: Access to Information;active method;Administrative Supplement;anti-cancer research;Award;Budgets;Cancer Center;Cancer Center Support Grant;cancer health disparity;Catchment Area;Clinical Data;Clinical Protocols;Clinical Trials;Communication;Communities;Community Outreach;Contracts;Core Facility;Dana-Farber Cancer Institute;Data;data management;Dedications;Dependence;Development;Education and Outreach;Ensure;Equity;Evaluation;Event;Funding;Funding Opportunities;Goals;Grant;Guidelines;Home;Informatics;Infrastructure;Institution;Institutional Review Boards;Leadership;Malignant Neoplasms;Manuals;member;Modeling;Monitor;news;operation;parent project;Peer Review;Performance;Pilot Projects;Policies;Process;programs;Protocols documentation;Publications;Reporting;Research;Resource Sharing;Resources;Safety;satisfaction;service member;Services;Site;Strategic Planning;Structure;Surveys;System;Technology;Training;Training and Education;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer

PHR: Project Narrative Not applicable.

PI_NAMEs: NADLER, LEE MARSHALL (contact)

PROJECT_TERMS: Academy;Address;American Association of Cancer Research;American Society of Clinical Oncology;anti-cancer research;Applied Research;Articulation;Award;Basic Science;Cancer Burden;Cancer Center;Cancer Education Grant Program;Cancer Patient;cancer research center director;career;Career Choice;career development;Career Mobility;Catchment Area;Charge;Clinical Sciences;college;Creativeness;Dana-Farber Cancer Institute;Dedications;Department chair;Education;Ensure;Environment;Equity;experience;Faculty;Funding;Future;Goals;Government;Grant;high needs schools;high school;improved;Individual;Industry;innovation;Institution;Internships;Life Cycle Stages;Malignant Neoplasms;medical schools;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Minority;Minority Recruitment;minority student;minority trainee;Mission;Nobel Prize;Outcome;patient population;Peer Review;Pharmacists;Pharmacy facility;Population Research;Population Sciences;Postdoctoral Fellow;pre-doctoral;Preparation;programs;Reporting;Research;Research Personnel;Research Training;Resources;Risk;Scientist;Site;Source;STEM field;Strategic Planning;Structure;success;Sum;Talents;Training;Training Activity;Training and Education;training opportunity;Translational Research;Underrepresented Minority;United States National Academy of Sciences;United States National Institutes of Health;Woman

PROJECT_TITLE: Cancer Research and Training Coordination


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Diabetes;Neurosciences

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: This proposal entitled `Regulation of hippocampal function by central and peripheral IRS signaling', brings our core focus on insulin receptor substrates to bear on the medically important problem of how insulin resistance and diabetes promote cognitive decline. Our proposal investigates the function of the insulin receptor substrates in the hippocampus and in peripheral tissues to regulate cognitive function in aged mice during progressive metabolic disease. Our approach employs mice with unique patterns of Irs1 and Irs2 expression to distinguish effects of neuronal versus peripheral insulin signaling. Our innovative experimental models can reveal new mechanistic insights that can guide development of targeted strategies to prevent cognitive decline during diabetes.

PI_NAMEs: WHITE, MORRIS F. (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Ablation;Acute;Address;Affect;Age-associated memory impairment;Alzheimer's disease related dementia;Animals;Attenuated;attenuation;Beta Cell;Biological Assay;Biological Models;Blood Glucose;Brain;Cells;Clinical;Clinical Research;Cognitive;cognitive function;dentate gyrus;Development;Diabetes Mellitus;diabetic;Etiology;Experimental Models;experimental study;extend lifespan;Feedback;Female;Follistatin;FOXO1A gene;Genetic Transcription;Glucose;Health;Hepatic;Hippocampus;Human;human disease;Hyperglycemia;Impaired cognition;impaired glucose tolerance;Impairment;improved;innovation;insight;Insulin;Insulin deficiency;Insulin Receptor;Insulin Resistance;insulin secretion;insulin sensitivity;insulin signaling;Investigation;IRS1 gene;knock-down;Knock-out;knockout gene;Knockout Mice;Learning;life span;Liver;male;Measurement;Measures;Mediating;Medical;Metabolic;Metabolic Diseases;Methods;Modeling;morris water maze;mouse model;Mus;nerve stem cell;nestin protein;neurogenesis;Neurons;neuroprotection;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Nose;novel strategies;novel therapeutic intervention;old mice;Pancreas;Parahippocampal Gyrus;Pattern;Peripheral;Phosphorylation;prevent;promoter;Proteins;Publishing;reconstitution;Regulation;Research;Role;Serine/Threonine Phosphorylation;Signal Transduction;Site;Structure of beta Cell of islet;System;Testing;Tissues;Transgenes;Up-Regulation;Viral;Water;Weight Gain;Work


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: Project Narrative Not Applicable.

PI_NAMEs: TOLANEY, SARA M. (contact)

PROJECT_TERMS: Acceleration;Address;African American population;Age;age related;Antibody-drug conjugates;Artificial Intelligence;Basic Science;Biological;Biology;Brain;BRCA1 gene;breast cancer metastasis;Breast Cancer Patient;cancer care;cancer cell;Cancer Center;Cancer Center Support Grant;Caring;Catchment Area;Cells;Characteristics;Clinic;Clinical;Clinical Trials;Collaborations;Collection;Cytotoxic T-Lymphocytes;Dana-Farber Cancer Institute;Data;Detection;Diagnosis;Direct Costs;Disease;Disparity;Early Diagnosis;Ensure;ERBB2 gene;FDA approved;Fertility;Funding;Genomics;Goals;Heterogeneity;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;Individual;Infrastructure;innovation;Institution;inter-institutional;investigator-initiated trial;Knowledge;Laboratories;Late Effects;Lesion;Local Therapy;Malignant Breast Neoplasm;Malignant Neoplasms;Massachusetts;member;Metastatic malignant neoplasm to brain;Mission;Morbidity - disease rate;mortality;mouse model;Mutation;Nature;novel strategies;Oncology;Paclitaxel;Paper;Pathogenesis;patient derived xenograft model;Patient Outcomes Assessments;Patients;Peer Review Grants;phase II trial;Pre-Clinical Model;preclinical study;Prevention;Prognosis;programmed cell death ligand 1;programs;Publishing;Race;racial disparity;Regimen;Research;Research Personnel;Resistance;Resource Sharing;screening;Socioeconomic Status;Strategic Planning;survivorship;Systemic Therapy;T cell response;targeted treatment;Toxic effect;Translational Research;translational study;Translations;Trastuzumab;trial comparing;triple-negative invasive breast carcinoma;tumor;Tumor Biology;tumor microenvironment;Women's cohort;Work;young woman

PROJECT_TITLE: Program 01 Breast Cancer


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

PI_NAMEs: BALK, STEVEN P. (contact)

PROJECT_TERMS: abiraterone;Acceleration;Acetates;Address;African American;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;antagonist;AR gene;Armenia;Attention;Biological Models;Biological Process;biomarker driven;Biostatistics Core;cancer biomarkers;cancer cell;Cancer Center;Cancer Center Support Grant;cancer epidemiology;cancer genetics;Cancer Patient;Castrate sensitive prostate cancer;Catchment Area;CDK4 gene;Cells;ChIP-seq;Clinical;Clinical Investigator;clinical practice;clinical translation;Clinical Trials;Collaborations;collaborative trial;community engagement;Community Outreach;constitutive expression;Data;Data Science;Detection;Development;Direct Costs;Early treatment;efficacy evaluation;Elements;Enhancers;enzalutamide;Epigenetic Process;exome sequencing;Funding;gene repression;Genes;Genets;genome sequencing;genome wide association study;genome-wide;genomic biomarker;improved;improved outcome;in vivo;inhibitor;Institution;inter-institutional;International;Length;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Massachusetts;Mediating;member;men;Mission;multidisciplinary;Mutate;Mutation;Nature;Neoadjuvant Therapy;Neoplasm Metastasis;next generation;Nonmetastatic;novel;Paper;patient population;Patients;PD-1 blockade;Peer Review Grants;phase II trial;phase III trial;Phenotype;programmed cell death ligand 1;programs;Prostate;prostate cancer risk;Publishing;Reporting;Repression;Research;Research Design;Research Personnel;Resistance;resistance mechanism;Resource Sharing;Resources;risk stratification;RNA Splicing;Sampling;Series;Signal Transduction;Structure;Surrogate Endpoint;Training;transcriptome;tumor;tumor progression;Tumor Suppressor Genes;Upstream Enhancer;Variant;whole genome

PROJECT_TITLE: Program 03 Prostate Cancer


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE Children from disadvantaged backgrounds, on average exhibit disparities in academic achievement and cognitive development, compared to their peers from higher socioeconomic status (SES) backgrounds. The proposed studies will investigate the role of specific aspects of children’s early language input on the development of neural networks supporting the development of language, executive functioning, and social cognition, and how these may ultimately drive SES differences in academic achievement. Findings from this work have the potential to inform maximally impactful interventions to reduce achievement gaps and improve cognitive outcomes for children from all backgrounds.

PI_NAMEs: ROMEO, RACHEL RENE (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Academic achievement;Achievement;Affect;Affective;Age;Area;Award;Brain;career;Child;Child Language;Childhood;Cognitive;cognitive development;cognitive neuroscience;cognitive skill;cohort;Complex;critical period;Data;Data Collection;Development;disadvantaged background;Disparity;early adolescence;early experience;elementary school;Environmental Risk Factor;executive function;Exhibits;Exposure to;flexibility;Home;improved;Income;Inferior;innovation;Intervention;Investigation;kindergarten;Knowledge;Language;Language Development;Left;Linguistics;Link;Longitudinal Studies;low socioeconomic status;Mediating;Methodology;Modeling;multimodal neuroimaging;multimodality;neural;neural network;Neurocognitive;neurodevelopment;neuromechanism;Neuronal Plasticity;novel;Nursery Schools;Outcome;peer;Phase;Play;Positioning Attribute;prevent;Readiness;Research;research faculty;Role;Sampling;scaffold;Schools;Shapes;Short-Term Memory;skills;social;social cognition;Social Development;social factors;socioeconomic disparity;Socioeconomic Status;Structure;success;support network;Support System;Surface;syntax;System;Techniques;Testing;theory of mind;Thick;Time;Training;white matter;Work

PROJECT_TITLE: Language Input as a Mechanism Underlying Socioeconomic Disparities in Neurocognitive Development

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebral Palsy;Cerebrovascular;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_CITY: WACO

ORG_DEPT: CHEMISTRY

ORG_NAME: BAYLOR UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Neonatal and perinatal hypoxic-ischemic brain injury (HIBI) is a major cause of death and neurological damage in infants and children, and there is an unmet need for therapeutic options to prevent or reverse these effects. The plasma membrane protein TRPM7 is known to control critical cellular processes involved in oxygen- deprivation of the brain and to protect the brain from damage when suppressed, and the only known specific and potent inhibitor of TRPM7 is waixenicin A. The current proposal engages an interdisciplinary team to lay the groundwork for a viable therapeutic treatment option developed from waixenicin A based on this mechanism.

PI_NAMEs: FENG, ZHONG-PING ;FLEIG, ANDREA ;HORGEN, F DAVID;HULL, KENNETH GREGORY;MILLER, STEVEN P;ROMO, DANIEL  (contact);SUN, HONG-SHUO

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: ABCB1 gene;Acute;Address;Adverse event;adverse outcome;Affinity;analog;Animal Model;aqueous;Asphyxia;Behavioral;Binding;Biological Assay;Birth;Blood - brain barrier anatomy;blood-brain barrier penetration;blood-brain barrier permeabilization;Brain;Brain Hypoxia-Ischemia;Brain Injuries;Calcium;Cause of Death;Cell membrane;Cell Physiology;Central Nervous System Diseases;Cerebral Palsy;Chemicals;Child;Chimeric Proteins;Chronic;Clinical;clinical candidate;Competence;coral;Cytochrome P450;Data;Death Rate;deprivation;Derivation procedure;Development;Diagnosis;Diagnostic;disability;Disease;Dissociation;drug development;Drug Kinetics;Drug Targeting;economic implication;Effectiveness;Electrophysiology (science);Elements;Event;evidence base;Goals;Hawaiian;Healthcare Systems;Hour;Hypoxia;hypoxia neonatorum;Hypoxic Brain Damage;Hypoxic-Ischemic Brain Injury;improved;In Vitro;in vitro testing;in vivo;Infant;inhibitor;innovation;Ion Channel;Ischemia;Lead;Libraries;life time cost;Light;marine;marine natural product;Membrane Proteins;Microsomes;Modeling;Molecular Probes;Morbidity - disease rate;mortality;mouse model;Mus;natural hypothermia;Natural Source;Neonatal;neonatal hypoxic-ischemic brain injury;neonatal mice;neonate;Nervous System Trauma;Neurologic;Neurons;neuroprotection;Neuropsychology;new therapeutic target;Newborn Infant;novel therapeutic intervention;Outcome;Oxygen;Penetration;Perinatal;Perinatal Hypoxia;Pharmaceutical Chemistry;pharmacologic;pharmacophore;Phase;Phosphotransferases;Plasma Proteins;pre-clinical;Premature Infant;prevent;Property;protective effect;Qualifying;Recovery;Rest;Safety;screening;Slice;socioeconomics;Solubility;standard of care;Structure-Activity Relationship;Survivors;Testing;Therapeutic;Therapeutic Agents;therapeutic candidate;Therapeutic Intervention;Time;Validation;Work

PROJECT_TITLE: Development of the waixenicin A pharmacophore as a therapeutic intervention for neonatal hypoxic brain injury

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: LANE, ANDREW A (contact)

PROJECT_TERMS: Acute leukemia;Adoptive Cell Transfers;Allogenic;analog;anti-cancer research;asparaginase;Azacitidine;bench to bedside;Bone Marrow;Boston;C2H2 Zinc Finger;cancer cell;Cancer Center;Cancer Center Support Grant;Cardiovascular Diseases;Caring;CDK4 gene;Cell fusion;Cells;Cellular biology;Chemicals;Childhood Acute Lymphocytic Leukemia;Childhood Leukemia;Chronic Leukemia;Clinic;Clinical;Clinical Trials;Collaborations;Communities;Community Outreach;CRISPR/Cas technology;Dana-Farber Cancer Institute;Dendritic Cells;Development;Direct Costs;Disease;Dominant-Negative Mutation;Dysmyelopoietic Syndromes;early phase clinical trial;Education and Outreach;Epigenetic Process;Event;FLT3 gene;Funding;Genetic;genetic predictors;Genome engineering;Goals;Grant;Hematopoiesis;Human;immunodeficiency;Immunologist;Immunotherapy;improved;in vivo Model;Infrastructure;inhibitor;innovation;Institution;inter-institutional;International;Investigation;investigator-initiated trial;Journals;Laboratories;Lead;Leadership;leukemia;Malignant Neoplasms;Massachusetts;Medicine;meetings;member;Mission;Modeling;Molecular Biology;mutant;Mutation;Myeloproliferative disease;Nature;New England;new therapeutic target;next generation;novel;novel therapeutics;open source;outcome prediction;outreach;Paper;Pathogenesis;patient derived xenograft model;Patient-Focused Outcomes;Peer Review;Peer Review Grants;Population Sciences;Positioning Attribute;Precancerous Conditions;Preleukemia;prognostic value;Program Research Project Grants;programs;Protocols documentation;Publishing;Relapse;Research;Research Personnel;Resource Sharing;Science;Scientist;single-cell RNA sequencing;standard of care;Stem cell transplant;stem cells;System;Taxonomy;tenure track;Thalidomide;therapeutic target;TP53 gene;Training;Translating;Translational Research;Translations;Universities;Vaccination;Zebrafish

PROJECT_TITLE: Program 04 Leukemia


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: NARRATIVE The present application will test new models by which certain highly-flexible regions in proteins help control when and where DNA replication begins, and how chromosomes are organized inside cells. The proposed studies are pertinent to understanding basic mechanisms of human diseases such as cancer or certain forms of developmental dwarfism that arise from defects in the timing of division and genetic stability.

PI_NAMEs: BERGER, JAMES M.;BOTCHAN, MICHAEL R. (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Area;ATP phosphohydrolase;Automobile Driving;Behavior;Binding;Biochemical;Biochemistry;Biology;Biophysical Process;Cell Cycle Regulation;Cell Proliferation;Cells;cellular imaging;Chromatin;Chromosome Structures;Chromosomes;Complex;Data;Defect;Development;Disease;DNA;DNA Binding;DNA biosynthesis;Dwarfism;Elements;Eukaryota;Event;Exclusion;experience;flexibility;Gene Expression;Gene Silencing;Genetic;Genome;Goals;helicase;Heterochromatin;human disease;Image;imaging approach;In Vitro;in vivo;insight;interest;Intervention;Knowledge;Laboratory Finding;Lead;Liquid substance;Maintenance;Malignant Neoplasms;melting;Membrane;Modeling;Molecular;Molecular Biology;Mutagenesis;novel;Nucleic Acids;ORC1L gene;origin recognition complex;Outcome;Pathology;Pathway interactions;Peptide Initiation Factors;Phase;Physical condensation;Probability;programs;Prokaryotic Initiation Factor-3;Property;prospective;protein protein interaction;Proteins;Proteome;Reagent;recruit;Replication Initiation;Replication Origin;Role;S phase;Signal Transduction;Sorting;Specific qualifier value;Specificity;structural determinants;Structure;System;Testing;tumorigenesis;Work

PROJECT_TITLE: Studies to Explore DNA Replication Proteins in Functional Assemblies through Intrinsically Disordered Domains

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Cancer;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Prevention;Rare Diseases

PI_NAMEs: GHOBRIAL, IRENE M. (contact)

PROJECT_TERMS: Acceleration;African American population;anti-tumor immune response;B-Cell Antigen Receptor;B-Cell Lymphomas;base;Basic Science;bench-to-bedside translation;Boston;Cancer Center;Cancer Center Support Grant;Caring;Catchment Area;Chronic Lymphocytic Leukemia;Clinic;clinical development;Clinical Research;Clinical Trials;Collaborations;Core Facility;Dana-Farber Cancer Institute;Dedications;Development;Direct Costs;Disease;disorder prevention;Early Intervention;Elements;Enhancers;FDA approved;Follicular Lymphoma;Funding;General Hospitals;Genetic;Genetic Predisposition to Disease;Genetic Transcription;Genomics;Guidelines;health disparity;Hematologic Neoplasms;Hodgkin Disease;Hospitals;Immune response;immunoregulation;improved;Individual;Infrastructure;inhibitor;innovation;insight;Institution;inter-institutional;interest;Israel;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;Lesion;Lymphoid;Lymphoid Cell;lymphoid neoplasm;Lymphoma;Malignant lymphoid neoplasm;Malignant Neoplasms;Massachusetts;Mediastinal;Medical center;member;Mission;Molecular;Molecular Analysis;Molecular Profiling;mouse model;multidisciplinary;Multiple Myeloma;Mutation;Natural History;New Agents;next generation;Nivolumab;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenic;Paper;Participant;Pathogenicity;Patients;Pediatric Hospitals;Peer Review Grants;pembrolizumab;Plasma Cell Neoplasm;Plasma Cells;Play;preclinical development;Predisposing Factor;Prevention;prognostic value;programs;Proteomics;Publishing;Receptor Signaling;Research;Research Personnel;Resources;Role;Structure;Testing;Thalidomide;Therapeutic;Therapeutic Agents;Training;Translating;Translational Research;Translations;Treatment outcome;tumor;Update;Woman;Work

PROJECT_TITLE: Program 06 Lymphoma and Myeloma


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative The goal of this proposal is to develop Galaxy platform into the comprehensive data analysis medium connecting biomedical experts across the full spectrum of skill sets, scientific domains, and research practices. For biomedical researchers it will provide a powerful analysis platform populated with the latest tools and data. For tool developers it will provide a community-supported mechanism for deploying tools before a wide audience of users.

PI_NAMEs: NEKRUTENKO, ANTON  (contact);SCHATZ, MICHAEL

PROGRAM_OFFICER_NAME: WELLINGTON, CHRISTOPHER

PROJECT_TERMS: Acute;Address;Administrator;Adopted;Area;Biological;Biological Sciences;Biology;Cells;Collaborations;Collection;Communities;Complex;Complex Analysis;Computer Analysis;Computer software;computerized data processing;Custom;Data;data access;Data Analyses;data exploration;data integration;data modeling;Data Science;Data Security;Data Set;Decision Making;Democracy;design;Development;Dimensions;dissemination strategy;Documentation;editorial;Education and Outreach;Educational workshop;Engineering;Environment;expectation;experience;Experimental Designs;experimental study;Exposure to;Galaxy;genomic data;Genomics;Goals;Growth;Human;Infrastructure;large datasets;large scale data;Lead;Leadership;Maintenance;Manuscripts;Methods;Modeling;Modernization;multiple omics;open source;privacy protection;Process;Provider;Publications;rapid growth;Research;Research Personnel;Running;Sampling;Security;skills;success;System;Technology;Time;tool;tool development;Training;trend analysis;web portal;Work

PROJECT_TITLE: Democratization of Data Analysis in Life Sciences Through Galaxy


NIH_SPENDING_CATS: Breast Cancer;Cancer;Digestive Diseases;Nutrition;Obesity;Precision Medicine;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: ELIASSEN, A. HEATHER  (contact)

PROJECT_TERMS: Acceleration;Address;Androgen Receptor;Area;Aspirin;Biological Markers;biomarker identification;Blood;Breast;Cancer Center;Cancer Center Support Grant;cancer epidemiology;Cancer Patient;cancer prevention;cancer subtypes;Cancer Survivorship;career;Catchment Area;Clinical;Clinical Trials;cohort;Cohort Studies;Collaborations;Complex;Data;Diagnosis;Diet;Direct Costs;Discipline;Disease;energy balance;Epidemiologist;Epidemiology;epidemiology study;Etiology;Feces;follow-up;Fostering;Funding;gastrointestinal;genetic variant;genomic biomarker;Genomics;Goals;Histology;improved;Incidence;Individual;Inherited;innovation;Institution;inter-institutional;Investments;Laboratory Study;life span;lifestyle factors;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic Density;Massachusetts;member;Metabolic Marker;Metabolism;microbiome;Mission;modifiable risk;Molecular;molecular marker;mortality;National Cancer Institute;next generation;nonalcoholic steatohepatitis;novel;Obesity;Observational epidemiology;Outcome;Paper;Patient Outcomes Assessments;Patients;Peer Review;Peer Review Grants;Pharmaceutical Preparations;Phase;Physical activity;Postdoctoral Fellow;Predictive Cancer Model;predictive marker;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Productivity;Prognostic Marker;programs;prospective;Publications;Publishing;randomized trial;Recording of previous events;Research;Research Methodology;Research Personnel;Risk;Risk Factors;Role;Science;screening;Strategic Planning;Structure;student mentoring;Tissues;tool;Training;Translating;Translations;tumor;Tumor Subtype;Underrepresented Minority;understudied cancer;United States National Institutes of Health;Urine;Woman

PROJECT_TITLE: Program 07 Cancer Epidemiology


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MICHOR, FRANZISKA  (contact)

PROJECT_TERMS: Algorithms;anti-cancer research;Basic Cancer Research;Big Data;biobank;biomarker discovery;biomathematics;Biostatistics Shared Resource;Cancer Center;cancer genome;cancer immunotherapy;Cancer Patient;cancer therapy;Cells;Chemotherapy and/or radiation;Chemotherapy-Oncologic Procedure;ChIP-seq;Clinical;Clinical Trials Design;Collaborations;Communities;community center;Complex;computer science;Computer software;Computing Methodologies;Core Facility;Creativeness;CRISPR/Cas technology;Data;Data Analyses;data integration;Data Science;design;Development;Diagnosis;Direct Costs;DNA;Dose;Early Diagnosis;Electronic Health Record;Etiology;Fostering;Foundations;Funding;Generations;genome analysis;genome sequencing;Genomics;Goals;Grant;Heterogeneity;Human;Image;Image Analysis;Immunotherapy;Infrastructure;innovation;Institution;inter-institutional;interdisciplinary collaboration;interest;Investigation;machine learning method;Malignant Neoplasms;Mathematics;member;Methods;Methylation;Mission;Modeling;multiple omics;NCI Center for Cancer Research;novel;Oncologist;open source;Paper;Peer Review Grants;Population;Population Study;Positioning Attribute;predictive modeling;Prevention;Prognosis;programs;Publishing;Recording of previous events;Research;Research Activity;Research Design;Research Personnel;research study;Research Support;response;Risk Assessment;RNA;Role;scalable algorithms;Science;service programs;Services;skills;software development;Software Tools;statistical and machine learning;statistics;Strategic Planning;Testing;tool;Training;Training Programs;treatment response;trend;tumor immunology;Underrepresented Minority;whole genome;Work

PROJECT_TITLE: Program 08 Cancer Data Sciences


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Patient Safety;Sleep Research;Substance Misuse

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Insufficient and poor sleep is pervasive among individuals with shoulder conditions requiring surgical intervention. Shortened sleep and increased sleep disturbances induce an outsized inflammatory reaction, which sensitizes the nociceptive response and may increase susceptibility for developing chronic post-surgical pain and the subsequent need for prolonged postoperative opioid therapy. Therefore, this prospective study will utilize daily sleep data, collected from wearable devices, and inflammatory markers to examine associations with patient-reported pain outcomes and opioid utilization up to 3 months after shoulder surgery.

PI_NAMEs: GIORDANO, NICHOLAS A (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: actigraphy;Acute;Acute Pain;Area;biopsychosocial;C-reactive protein;career development;Characteristics;Chronic;chronic pain;chronic pain patient;Classification;Clinical Research;common symptom;cytokine;Data;Data Collection;Development;Devices;Drowsiness;Drug usage;Electronics;Event;experience;Hyperalgesia;Impairment;improved;Incidence;Individual;Inflammation;Inflammatory;inflammatory marker;Interleukins;Intervention;Leadership;Link;Longitudinal Studies;Measures;Mentors;Modeling;Monitor;monitoring device;National Institute of Drug Abuse;Nature;nociceptive response;novel;Operative Surgical Procedures;Opioid;opioid therapy;opioid use;Orthopedic Surgery;Outcome;Pain;pain chronification;Pain intensity;Pain management;pain outcome;pain sensitivity;Participant;Pathway interactions;patient oriented;Patient Self-Report;Patients;Perioperative;Pharmaceutical Preparations;poor sleep;Postoperative Pain;Postoperative Period;Predisposition;prescription opioid;prevent;Prospective Studies;Quality of life;Reaction;Records;Replacement Arthroplasty;Reporting;Research;Risk;Risk Estimate;Role;Scientist;Shoulder;skills;Sleep;Sleep Deprivation;Sleep disturbances;sleep pattern;sleep quality;Slow-Wave Sleep;Symptoms;System;systemic inflammatory response;Time;TNF gene;Visualization;wearable data;wearable device

PROJECT_TITLE: Differential Susceptibility for Developing Chronic Post-Surgical Pain Across Sleep Trajectories and Inflammatory Presentations

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine

PI_NAMEs: VAN ALLEN, ELIEZER M (contact)

PROJECT_TERMS: Acceleration;Affect;algorithm development;Architecture;Area;Basic Science;Bioinformatics;Biological;cancer care;Cancer Center;Cancer Center Support Grant;cancer genetics;Cancer Patient;cancer therapy;Catchment Area;Cells;Chromatin;chromatin remodeling;CLIA certified;Clinical;Collaborations;Computer Analysis;Counseling;Dana-Farber Cancer Institute;Data Analyses;Development;Diagnosis;Direct Costs;Elements;Enhancers;Epigenetic Process;exome;Funding;gene discovery;Gene Expression;Gene Mutation;Genes;Genetic;Genetic Transcription;Genome;genome annotation;genomic profiling;Genomics;Germ Lines;Immune;improved;Institution;inter-institutional;interest;Knowledge;Leadership;Malignant Neoplasms;Massachusetts;Massive Parallel Sequencing;member;Methods;Mission;Mutation;Names;novel;novel therapeutic intervention;Oncogenes;Oncogenic;Paper;Peer Review Grants;Perception;Population Sciences;precision medicine;precision oncology;Prevention;programs;promoter;Publishing;racial disparity;Research Personnel;Resistance;resistance mechanism;response;Risk;screening;single cell analysis;socioeconomic disparity;Strategic Planning;targeted cancer therapy;Technology;technology development;Testing;Therapeutic;Translating;tumor heterogeneity;tumorigenesis;Untranslated RNA;whole genome

PROJECT_TITLE: Program 09 Cancer Genetics


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cerebral Palsy;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rehabilitation;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: TUCSON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  Cerebral palsy (CP) is the major neurodevelopmental disorder affecting physical function and we and others have shown that mutations in single genes can disrupt normal brain development and lead to CP. Recessively inherited CP accounts for about one-third of genetic cases and features neurologically-healthy carrier parents and affected children who inherit a mutant copy of a given gene from both their mother and their father. This discovery based initiative will study highly genetically-informative families from Africa, the Middle East and Southeast Asia in order to discover CP-associated genes exhibiting recessive inheritance; such discoveries are anticipated to improve CP diagnosis and care by bringing molecular insights to the CP community.

PI_NAMEs: KRUER, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Accounting;Affect;Africa;astrocyte progenitor;autosome;Biological Assay;Biological Models;Blood;Brain;Brain Hypoxia-Ischemia;Candidate Disease Gene;Caring;Catalogs;cell type;Cells;Cerebral Palsy;Child;Childhood;Clinical;clinical care;cohort;Collaborations;Collection;Communities;Complement;Complex;consanguineous family;Consanguinity;Consent;Copy Number Polymorphism;Data;Data Set;Development;Diagnosis;Disease;DNA Sequence Alteration;Drosophila genus;Eating;Enrollment;Environment;Etiology;Exhibits;exome;exome sequencing;Face;Family;Family member;Far East;Fathers;fly;functional genomics;gene discovery;gene environment interaction;Genes;Genetic;Genetic Diseases;Genome;Genomics;Hand;Haplotypes;Human;human induced pluripotent stem cells;hypoxic ischemic injury;identity by descent;implicit bias;improved;In Vitro;in vivo;in vivo Model;Individual;Induced pluripotent stem cell derived neurons;Infection;Inherited;insertion/deletion mutation;insight;Knock-out;Laboratories;loss of function;Maps;Mediating;Middle East;Modeling;Molecular;Morphology;Mothers;Motor;Motor disability;Movement;Movement Disorders;mutant;Mutation;Neurobiology;Neurodevelopmental Disorder;Neurologic;Neurons;novel;Nucleotides;Oxygen;Pain;Parents;Pathway interactions;Patients;perinatal stroke;Persons;Phenotype;Physical Function;Physicians;Play;Population;premature;prenatal;pressure;protein function;protein structure;Proteins;Quality of life;Radiology Specialty;Research;Research Personnel;Resources;Risk Factors;RNA;RNA Splicing;Role;Sampling;segregation;Series;Side;Signs and Symptoms;Site;Smooth Muscle;Southeastern Asia;Specialist;Stream;Stroke;Structure-Activity Relationship;Symptoms;System;Time;Validation;Variant;variant of interest;variant of unknown significance;Walking;Yeasts

PROJECT_TITLE: Genomic analysis of the Multiplex, Autozygous Populations in Cerebral Palsy (MAP CP) cohort: a focused approach to a complex disease

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Prevention

PI_NAMEs: MACK, JENNIFER W (contact)

PROJECT_TERMS: accountable care organization;Address;Advanced Malignant Neoplasm;Affordable Care Act;Area;Basic Science;cancer care;Cancer Center;Cancer Center Support Grant;cancer diagnosis;Cancer Patient;Cancer Survivor;cancer therapy;cancer type;care delivery;Caregivers;Caring;Chronic;Clinical;Clinical Informatics;Clinical Investigator;Clinical Sciences;Clinical Trials;Collaborations;Communities;Dana-Farber Cancer Institute;Data Sources;design;Diagnosis;Direct Costs;effective intervention;Effectiveness;end of life care;Ensure;Equity;ethnic minority;evidence base;Exercise;experience;Family;Family Study;fitness;Fostering;Funding;Goals;health care cost/financing;Health Care Reform;health related quality of life;Health Services Accessibility;Healthcare;hospice environment;improved;Individual;innovation;Institute of Medicine (U.S.);Institution;inter-institutional;Intervention;Investments;knowledge translation;Malignant Neoplasms;Measures;member;Methods;Mission;Modeling;next generation;Oncology;Outcome;palliative;Palliative Care;Paper;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;patient-clinician communication;Patient-Focused Outcomes;Patients;Peer Review;Peer Review Grants;Phase;Population;Practice Guidelines;precision medicine;Prevention;Program Research Project Grants;programs;Publishing;racial minority;Reporting;Research;Research Methodology;Research Subjects;routine practice;screening;Screening for cancer;Services;socioeconomic disadvantage;Symptom Burden;symptom management;System;Testing;tool;Training;Translating;Translational Research;treatment trial;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: Program 10 Cancer Care Delivery Research


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cardiovascular;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Diabetes;Emerging Infectious Diseases;HIV/AIDS;Heart Disease;Infectious Diseases

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative We propose to establish the University of Pittsburg-Mozambique HIV Research Training Program (Pitt- MozHRTP), which has as its primary goal the enhancement of research capacity in the areas of COVID-19, cardiovascular diseases, and diabetes in people with HIV. This will be accomplished by an expert, multidisciplinary team of research mentors and excellent training opportunities at the University of Pittsburgh, Pittsburgh, USA and the University of Stellenbosch, Cape Town, South Africa. By the end of the five-year funding period, we anticipate that we will have made a huge impact on HIV research capacity in Mozambique.

PI_NAMEs: HARRISON, LEE H (contact);NACHEGA, JEAN BISIMWA;VIEGAS, EDNA

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Area;Biometry;Capital;Cardiovascular Diseases;Cities;Clinical;combat;COVID-19;Diabetes Mellitus;Doctor of Philosophy;doctoral student;Educational workshop;Epidemic;Epidemiology;experience;Fellowship;Funding;Health;HIV;HIV Infections;Institution;Investments;Laboratories;Mentors;Mozambique;multidisciplinary;Operations Research;Persons;Postdoctoral Fellow;programs;Public Health;Research;Research Training;Resources;Science;Sister;Site;South Africa;Students;summer institute;Training;training opportunity;Training Programs;United States National Institutes of Health;Universities

PROJECT_TITLE: Pitt-Mozambique Training Program(Pitt-MozHRTP) in COVID-19, Cardiovascular Disease, and Diabetes in People with HIV


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunization;Immunotherapy;Vaccine Related

PI_NAMEs: WUCHERPFENNIG, KAI W (contact)

PROJECT_TERMS: Acceleration;Address;Adoptive Cell Transfers;Advanced Development;Affect;Age;Animal Model;anti-tumor immune response;biomarker identification;Biomedical Engineering;Cancer Center;Cancer Center Support Grant;cancer immunotherapy;Cancer Patient;cancer type;Cancer Vaccines;CAR T cell therapy;cell motility;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chimeric antigen receptor T cells;Clinical;Clinical Trials;Collaborations;Combined Modality Therapy;Core Facility;Dana-Farber Cancer Institute;Dendritic Cells;Development;Direct Costs;Disease;Funding;Future;Glioblastoma;Goals;Heterogeneity;high dimensionality;Human;Imaging Techniques;Immune;immune checkpoint blockade;Immune response;immune-related adverse events;Immunologist;Immunology;immunoregulation;Immunosuppression;Immunotherapy;immunotherapy clinical trials;Inflammatory;Injections;insight;Institution;Integration Host Factors;inter-institutional;Intervention;Life;lymph nodes;Malignant Neoplasms;Melanoma;member;Mentors;microbiome;Mission;Molecular;Monitor;Monoclonal Antibodies;neoantigen vaccine;neoantigens;novel;novel therapeutic intervention;Obesity;Oncologist;Paper;Pathway interactions;Peer Review Grants;Peptides;Phase I Clinical Trials;Phase II Clinical Trials;Productivity;programs;Publishing;recruit;Research Personnel;Resistance;response;Safety;Sampling;senior faculty;side effect;single-cell RNA sequencing;Site;Solid Neoplasm;Strategic Planning;T cell receptor repertoire sequencing;T cell response;Technology;Testing;therapy outcome;Toxic effect;Training;Translating;translational scientist;Translations;treatment strategy;Tumor Escape;Tumor Immunity;tumor immunology;tumor microenvironment;tumor-immune system interactions;Work

PROJECT_TITLE: Program 11 Cancer Immunology


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: LA JOLLA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Noise-induced hearing loss affects almost a billion people worldwide yet is currently untreatable. Our research seeks to enhance our understanding of the protection mechanisms that prevent noise-induced hearing loss. The results of this project are expected to open the door for the development of novel therapeutics.

PI_NAMEs: FRIEDMAN, RICK A (contact);HOELZ, ANDRE

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Adult;Affect;aged;attenuation;base;Binding;Biochemical;Biochemistry;Biological Assay;Biology;Candidate Disease Gene;candidate identification;Cell Nucleus;Cell Survival;Cells;Cellular biology;Cochlea;Complex;cost;Cryoelectron Microscopy;Cytoplasm;Data;Development;Diagnosis;Disabling;Disease;Exposure to;Freedom;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;genetic approach;genome wide association study;Goals;Hair Cells;Hearing;Hearing Aids;hearing impairment;hearing loss risk;Human;Individual;Inner Hair Cells;Intervention;Karyopherins;Knowledge;Laboratories;Link;Measures;Metabolism;Molecular;Mus;Neurons;Noise;noise exposure;Noise-Induced Hearing Loss;novel;novel therapeutics;Nuclear;Nuclear Export;Nuclear Import;nucleocytoplasmic transport;Nucleoplasm;operation;Outcome;Pathway interactions;Persons;Phosphorylation;Physiological;Physiology;Populations at Risk;Predisposition;presynaptic;prevent;Prevention;Prevention therapy;PRKAG2 gene;protective pathway;Recreation;repaired;Research;response;ribbon synapse;risk prediction;Role;service member;structural biology;Structure;Synapses;targeted treatment;Testing;Tinnitus;trafficking;X-Ray Crystallography

PROJECT_TITLE: Mechanisms of protection from noise-induced hearing loss

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Patient Safety;Precision Medicine;Social Determinants of Health

PI_NAMEs: SHAPIRO, GEOFFREY I (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Agreement;Area;Autopsy;Award;Basic Science;bench to bedside;Biological Markers;biomarker development;Biometry;BRAF gene;Bromodomain;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Patient;Cancer Therapy Evaluation Program;cancer type;career;career development;CDK4 gene;Cell Cycle Regulation;clinical translation;Clinical Trials;Clinical Trials Network;cohort;Collaborations;community engagement;Community Outreach;Dana-Farber Cancer Institute;design;Development;Developmental Therapeutics Program;Direct Costs;Disease;Disseminated Malignant Neoplasm;DNA;DNA Repair;Drug Combinations;drug development;drug efficacy;Drug Kinetics;Drug resistance;Drug Screening;early phase clinical trial;early phase trial;Education;Enrollment;Ensure;Epigenetic Process;Equity;ERBB2 gene;Evaluation;exome sequencing;Fibroblast Growth Factor Receptors;Financial Support;Foundations;functional genomics;Funding;Genetic Transcription;Geography;Goals;immune checkpoint blockade;Immune checkpoint inhibitor;Immunologic Monitoring;Immunologics;Immunooncology;Industry;Infrastructure;inhibitor;Institution;inter-institutional;interdisciplinary collaboration;Investigational Therapies;kinase inhibitor;Laboratories;Laboratory Research;Lead;Leadership;liquid biopsy;low socioeconomic status;Lung;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Melanoma;member;Mentors;Minority Groups;Minority Participation;Mismatch Repair;Mission;Mitogen-Activated Protein Kinases;Modeling;Molecular;Molecular Profiling;Nonprofit Organizations;novel anticancer drug;Paper;Pathway interactions;patient navigation;Patient Selection;patient subsets;Patients;Peer Review Grants;Pharmaceutical Preparations;Pharmacodynamics;Phase;phase I trial;phase II trial;PIK3CA gene;PIK3CG gene;Play;Positioning Attribute;preclinical evaluation;programs;Protocols documentation;Publishing;research clinical testing;Research Personnel;Resistance;resistance mechanism;response;Role;Safety;satisfaction;Science;Signal Transduction;targeted agent;Therapeutic;Toxic effect;Training;transcriptome sequencing;translational approach;Translations;tumor;tumor-immune system interactions;U-Series Cooperative Agreements;underserved community;Underserved Population;Work

PROJECT_TITLE: Program 12: Developmental Therapeutics


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: MO

PHR: Project Narrative Alzheimer's Disease and Related Dementias (AD/ADRD) involve varied and progressive interactions between different aggregating proteins and brain cell types. To better understand the interdependence of these molecular and cellular changes, we will develop a fluorescence-based reporter of the protein transitions in a brain tissue model.

PI_NAMEs: HALFMANN, RANDAL ARTHUR (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Affect;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid;Astrocytes;Bacterial Artificial Chromosomes;Behavior;biophysical techniques;Brain;brain cell;brain tissue;Cell Communication;Cell Nucleus;cell type;Cell Volumes;Cells;Cerebrum;Chromosomal Stability;Clinical;Clone Cells;Coculture Techniques;comorbidity;Complex;Cytoplasm;Data;Dementia;Dependence;Engineering;Etiology;experimental study;Flow Cytometry;Fluorescence;Fluorescence Resonance Energy Transfer;fluorophore;Future;Genotype;Homeostasis;human induced pluripotent stem cells;Kinetics;liquid dynamics;Measurement;Microglia;Microscopy;Molecular;mutant;Nerve Degeneration;neural;Neuroglia;Neurons;Organoids;Paint;Pathogenicity;Patients;Phase;Phase Transition;Phenotype;Physical condensation;Physiological;Population;prevent;promoter;protein aggregation;protein expression;protein TDP-43;Proteins;proteostasis;Reporter;RNA-Binding Proteins;self assembly;System;Thermodynamics;Tissue Model;tool;transcriptome sequencing;transcriptomics;Transfection;Transgenes;Variant;Work

PROJECT_TITLE: Multilineage DAmFRET to investigate AD/ADRD protein phase behavior in neural tissue models


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Neurosciences;Osteoarthritis;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Osteoarthritis (OA) is a chronic and disabling condition characterized by joint pain, stiffness, and cartilage degradation. Current treatments focus on managing pain and do not alter disease fate. In this project, we will examine how controlling the activity of protein phosphatases contributes to joint pain and the presence of neurons in the joint.

PI_NAMEs: STAFF, NATHAN P;WESTENDORF, JENNIFER J (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: afferent nerve;Afferent Neurons;aggrecan;allodynia;Animal Model;Arthralgia;articular cartilage;Behavior;Behavior Therapy;Biological Assay;Biological Models;Cartilage;cartilage degradation;cartilage regeneration;Cells;Chondrocytes;Chronic;Confocal Microscopy;Data;Degenerative polyarthritis;Deterioration;Development;Disabling condition;Disease;experimental study;Fibroblasts;Goals;healthy volunteer;Human;Hypersensitivity;Immobilization;Immunohistochemistry;In Vitro;in vivo;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;inhibitor;Injections;Injury;innovation;Intra-Articular Injections;joint stiffness;Joints;Knee Injuries;Knowledge;Laboratories;Measures;Medial meniscus structure;Mitochondria;Mobility decline;Molecular;Mouse Strains;multidisciplinary;Mus;Natural regeneration;Nerve Fibers;nerve supply;Neurites;neurofilament;Neurons;Neurotransmitters;Nociception;Operative Surgical Procedures;osteoarthritis pain;Pain;pain behavior;Pain management;pain reduction;pain relief;palliative;Pathogenesis;Pathologic;Pathway interactions;Periosteum;Phenotype;Phosphoric Monoester Hydrolases;prevent;Protein phosphatase;Proteins;Proteomics;Publishing;Randomized;Rattus;regenerative;Reporter;RNA;Role;Saline;Sensory;sham surgery;Skin;small molecule inhibitor;Spinal Ganglia;subchondral bone;Substance P;Testing;Time;Tissues;transcriptome;transcriptomics;Traumatic Arthropathy;Work

PROJECT_TITLE: PHLPP inhibition and Osteoarthritis-Associated Pain

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PI_NAMEs: SYNGAL, SAPNA  (contact)

PROJECT_TERMS: 3-Dimensional;Area;Artificial Intelligence;Boston;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Detection;cancer diagnosis;cancer health disparity;cancer initiation;Cancer Patient;cancer prevention;cancer risk;cancer therapy;Clinical;Clinical Trials;Collaborations;Communities;community based practice;community engagement;Complex;critical period;Dana-Farber Cancer Institute;Development;Direct Costs;Disparity;Early Diagnosis;Ecosystem;Education;eHealth;Elements;Engineering;Epidemiology;Funding;General Population;Generations;Genetic;Genetic Risk;genome sequencing;Goals;Growth;high risk population;implementation science;improved;Individual;Infrastructure;innovation;Institution;inter-institutional;Intercept;interdisciplinary approach;interdisciplinary collaboration;invention;Knowledge;Lesion;Link;Malignant Neoplasms;member;Mission;multidisciplinary;Mutation;Nanotechnology;new technology;novel strategies;Outcome;Paper;Peer Review Grants;personalized approach;Populations at Risk;premalignant;prevent;Prevention;Prevention strategy;Probability;Process;programs;Publishing;Research;Research Personnel;Resource Sharing;Resources;Risk;Risk Assessment;Scientific Advances and Accomplishments;screening;Screening for cancer;skills;Strategic Planning;synergism;synthetic biology;technological innovation;Technology;technology platform;Testing;Time;Tissue Model;Training;Translations

PROJECT_TITLE: Program 60: Cancer Risk, Prevention, and Early Detection


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Understanding the rules which guide how neuronal patterns are transformed and utilized by downstream structures to produce behavior is critical for our understanding of how abstract patterns become actions and how such transformations are affected in disease. The present proposal examines how neuronal population patterns in upstream circuits are ‘read out’ by downstream observer circuits/mechanisms in the entorhinal cortex – hippocampus - neocortex loop by combining large-scale electrophysiology, optogenetics and imaging in behaving rodents.

PI_NAMEs: BASU, JAYEETA ;BUZSAKI, GYORGY  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Affect;Alzheimer's Disease;Area;Behavior;Brain;cell assembly;Cells;Communication;Coupling;Cytoplasmic Granules;dentate gyrus;Discrimination;Disease;Electrophysiology (science);entorhinal cortex;Epilepsy;experience;experimental study;Goals;granule cell;Hippocampus;Image;Individual;insight;Interneurons;Lateral;learned behavior;Learning;Link;Maps;Maze Learning;Medial;member;Memory;Neocortex;neocortical;Neurologic;neuronal circuitry;neuronal patterning;Neurons;Neurosciences;optical imaging;optogenetics;Parietal Lobe;Pattern;Physiological;Population;Probability;Psyche structure;Pyramidal Cells;Reader;Research Personnel;Rodent;Route;Signal Transduction;Sleep;Stimulus;Structure;Synapses;Testing;Translating;transmission process;vector

PROJECT_TITLE: Transformation of Neuronal Activity in the Entorhinal-hippocampal-neocortex Path

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


PI_NAMEs: POLYAK, KORNELIA  (contact)

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Area;Attention;Basic Cancer Research;Basic Science;Biochemical;Biochemistry;Bioinformatics;Biological Markers;Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer genome;cancer risk;cell behavior;Cells;Cellular biology;Chemicals;Chemistry;Chromatin;Chromosomal Breaks;chromothripsis;Clinic;Clinical;Clinical Investigator;clinical translation;Clinical Trials;Collaborations;Communities;complex biological systems;Cryoelectron Microscopy;Curiosities;Dana-Farber Cancer Institute;Development;Developmental Therapeutics Program;Direct Costs;Disease;Drug Targeting;druggable target;Early Diagnosis;Epigenetic Process;Evolution;Fostering;Functional disorder;functional genomics;Funding;Future Generations;Genetic;genome-wide;Genomic Instability;Goals;Home;improved;In Vitro;in vivo;insight;Institution;inter-institutional;Investigation;Laboratory Finding;Link;Malignant Neoplasms;Measurement;member;Metabolic;Metabolism;Mission;Molecular;molecular imaging;Molecular Machines;Natural Immunity;Neoplasm Metastasis;new technology;Normal Cell;novel therapeutic intervention;novel therapeutics;Oncogenic;Paper;particle;Pathway interactions;Patients;Peer Review Grants;Pharmaceutical Chemistry;Pharmaceutical Preparations;Population Sciences;Prevention;Process;Productivity;programs;protein degradation;Proteome;Proteomics;Publishing;recruit;Regulation;Research;Research Personnel;resistance mechanism;Resource Sharing;response;Scientist;single cell sequencing;single molecule;small molecule;Structure;symposium;synergism;Technology;temporal measurement;Testing;Therapeutic;Time;tool development;Training;Translating;translational applications;translational potential;Translational Research;translational scientist;tumor;tumor behavior;tumor heterogeneity;tumorigenesis;Underrepresented Minority;Visualization;Work

PROJECT_TITLE: Program 15: Cancer Cell Biology


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Genetics;Kidney Disease;Liver Disease;Pediatric;Polycystic Kidney Disease;Rare Diseases

ORG_CITY: SIOUX FALLS

ORG_NAME: SANFORD RESEARCH/USD

ORG_STATE: SD

PHR: Project Narrative These studies have the potential to discover novel epithelial functions of Notch signaling, novel Notch2 and Jag1 interacting proteins, novel genes regulated by Notch signaling, and to identify genetic enhancers/suppressor of JAG1/NOTCH2 mutation dependent kidney disease. We will progress towards finding molecular therapies to improve the health of humans suffering from kidney diseases due to mutations in JAG1 or NOTCH2, like the patients with Alagille Syndrome. In addition, understanding how Notch signaling regulates epithelial cell processes will have a broad impact on understanding Notch signaling as an epithelial tumor suppressor in certain cancers of the kidney, lung, skin, and head and neck.

PI_NAMEs: SURENDRAN, KAMESWARAN  (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Address;Alagille Syndrome;Alleles;autosomal dominant mutation;autosome;Cell Culture Techniques;Cell division;Cell Physiology;cell type;Cellular Assay;Child;Chronic Kidney Failure;Cilia;Code;Compensation;congenital anomalies of the kidney;Cyst;Cystic kidney;Cystic Kidney Diseases;Defect;DNA Sequence Alteration;End stage renal failure;Enhancers;Ensure;Epithelial Cells;Epithelium;exome sequencing;Exons;gene network;Genes;Genetic;Genetic Models;Genetic Variation;Genome;Head Cancer;Health;Human;improved;Kidney;kidney cell;Kidney Diseases;kidney epithelial cell;Knowledge;Length;Life;Ligands;Link;Maintenance;Malignant neoplasm of lung;Mediating;Mediator;Methods;Molecular;mouse model;Multicystic Dysplastic Kidney;Mus;mutant;Mutation;Neck;nephrogenesis;nephron progenitor;notch protein;Notch Signaling Pathway;notch-2 protein;novel;Pathogenicity;Pathway interactions;Patients;Penetrance;Peptides;Phenotype;Phytochemical;prevent;Process;Proteins;rare variant;receptor;Renal Carcinoma;renal epithelium;Reporting;Repression;Retrospective Studies;Scaffolding Protein;Severities;Shapes;Signal Transduction;Signaling Protein;Skin Cancer;small molecule;stem;Structure;Testing;Tumor Suppressor Proteins;Urinary tract;Variant

PROJECT_TITLE: Molecular and cellular basis of the renal diseases associated with Alagille Syndrome

STUDY_SECTION: KMBD

STUDY_SECTION_NAME: Kidney Molecular Biology and Genitourinary Organ Development[KMBD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Compounds that promote neuroplasticity, such as serotonergic psychedelics, have enormous potential for treating a variety of neuropsychiatric diseases including addiction. Recently, our group discovered that it is possible to engineer non-hallucinogenic analogs of psychedelics capable of promoting neuroplasticity and producing sustained antiaddictive effects after a single administration. The research described here seeks to develop high-throughput methods for identifying such compounds with the ultimate goal of developing new treatments for substance use disorders.

PI_NAMEs: OLSON, DAVID E (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Acute;addiction;Adverse effects;Amphetamines;analog;Animal Model;Atrophic;attentional modulation;Autopsy;Biological Assay;Biosensor;Brain-Derived Neurotrophic Factor;cannabinoid receptor;Cardiotoxicity;comorbidity;Cues;Data;Dendritic Spines;density;Disease;Dopamine Receptor;drug discovery;drug seeking behavior;Engineering;Environment;executive function;experimental study;Extinction;Family;FDA approved;Functional disorder;functional restoration;Genetic;Goals;Hallucinations;Hallucinogens;Heroin;human imaging;Iboga;Ibogaine;Impulsivity;in vivo;Knowledge;Libraries;Ligands;Literature;Lysergic Acid Diethylamide;Mediating;Medicine;Memory;Mental Depression;Methods;mimetics;Modeling;Molecular;Molecular Conformation;N,N-Dimethyltryptamine;neural circuit;Neuronal Plasticity;Neurons;neuropsychiatric disorder;Nicotine;novel;Opioid;Opioid Receptor;Optics;Pathologic;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Play;Post-Traumatic Stress Disorders;Prefrontal Cortex;Property;protective effect;psychostimulant;Psychotropic Drugs;Rapid screening;rational design;Relapse;Research;reward circuitry;Rewards;Rodent Model;Role;Safety;scaffold;screening;Self Administration;Serotonin Receptor 5-HT2A;side effect;Signal Transduction;small molecule;Structure;Structure-Activity Relationship;Substance Use Disorder;substance use treatment;Synapses;Technology;Testing;Therapeutic;therapeutic development;Therapeutic Effect;Time;tool;Tropanes;Tryptamines;Work

PROJECT_TITLE: High-throughput Identification of Non-hallucinogenic Psychoplastogens for Treating Addiction


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: BATCHELOR, TRACY T (contact)

PROJECT_TERMS: Achievement;addiction;Address;Adult;Adult Glioblastoma;Age;Anaplastic astrocytoma;Antibodies;Area;Astrocytoma;Award;Biology;Brain Neoplasms;cancer care;Cancer Center;Cancer Center Support Grant;career;career development;Cells;Central Nervous System;Central Nervous System Neoplasms;Chemicals;Child;Childhood;Childhood Brain Neoplasm;Childhood Glioma;Childhood Malignant Brain Tumor;Chromatin;Chromatin Remodeling Factor;Classification;Clinical;Clinical Trials;Collaborations;Communities;Core Grant;Country;Dana-Farber Cancer Institute;Dedications;Diagnostic tests;diffuse midline glioma;Direct Costs;Discipline;Disease;DNA Repair;Environment;Ependymoma;Epidermal Growth Factor Receptor;Epigenetic Process;Faculty;Fostering;Funding;Genes;Glioblastoma;Glioma;Grant;Grant Review;Histones;immune checkpoint blockade;Immunotherapy;improved;Inherited;insight;Institution;inter-institutional;International;Laboratories;Leadership;life span;loss of function mutation;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Malignant Neoplasms;member;meningioma;Mentored Clinical Scientist Development Program;Metabolic;Metabolic Pathway;Microglia;Mission;molecular diagnostics;Molecular Genetics;molecular pathology;mutant;neoantigen vaccine;Neoplasms;neoplastic cell;Nervous System;Neurilemmoma;neuro-oncology;Neurofibromin 2;Neurons;Neurosciences;novel therapeutics;Oncogenes;Oncogenic;Oncoproteins;Pediatric Oncology Group;Peer Review;Pharmaceutical Chemistry;Positioning Attribute;Prognosis;programs;Proliferating;Protein Kinase;Publications;Published Comment;recruit;Reporting;Research;Research Personnel;Research Priority;response;Scholarship;Science;Services;Site;skills;standard of care;Strategic vision;Structure;success;synthetic peptide;tenure track;Therapeutic;therapeutic target;tool;Training;tumor;tumor immunology;tumor metabolism;tumor microenvironment;Underrepresented Minority;Woman;Work;young adult

PROJECT_TITLE: Program 30: Neuro-Oncology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: PHYSICS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: The activity of cells and neural circuits are altered in Alzheimer's disease (AD), and may represent a point of therapeutic intervention to affect disease progression. We recently found that manipulating oscillations in the gamma range with noninvasive auditory and visual sensory stimuli promotes neuroimmune interactions and alleviates AD-associated pathology in multiple disease mouse models, but the mechanisms by which GENUS promotes neuroimmune interactions are not clear. We will investigate the effects and potential mechanisms by which GENUS impacts the cellular and molecular responses of neuroimmune interactions, particular those mediated by microglia, and how microglial AD risk genes, APOE4 and TREM2, modifies GENUS-mediated neuroimmune activity that could affect AD pathology and cognitive function.

PI_NAMEs: TSAI, LI-HUEI  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3-Dimensional;Affect;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;apolipoprotein E-4;APP-PS1;Area;Astrocytes;Auditory;behavioral outcome;Brain;Brain Diseases;Brain region;Cell Communication;Cell model;cell type;Cells;Cerebrovascular system;Coculture Techniques;Cognitive;cognitive function;cognitive performance;Complex;cytokine;Data;design;Development;Disease;Disease Progression;Electric Stimulation;Exhibits;experience;experimental study;Financial cost;Frequencies;Functional disorder;Gene Expression;Genetic Risk;genetic risk factor;Human;human induced pluripotent stem cells;hyperphosphorylated tau;Impaired cognition;improved;induced pluripotent stem cell;inflammatory modulation;Inflammatory Response;innovation;Intervention;Mediating;Memory Loss;Microglia;Modeling;Molecular;Morphology;mouse model;Mus;Mutation;Nature;Nerve Degeneration;neural;neural circuit;Neuroimmune;neuroinflammation;neuronal excitability;Neurons;neuroprotection;new technology;Outcome;Pathology;Pattern;Phagocytes;Phagocytosis;pharmacologic;Phenotype;Production;Publishing;response;Response to stimulus physiology;risk variant;Role;Sensory;sensory stimulus;Signal Transduction;single-cell RNA sequencing;Synapses;System;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic Intervention;TREM2 gene;uptake;Visual;Work

PROJECT_TITLE: Manipulating Neural Oscillations with Non-Invasive Sensory Stimulation for Alzheimer's Disease Intervention


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Heart transplantation has impacted the lives of thousands of patients with end-stage heart disease. A key unmet need in transplantation is to develop innovative and novel therapeutic strategies to improve the short- and long- term outcomes of heart transplantation. This project seeks to investigate the mechanisms by which β3 integrin regulates alloimmune responses.

PI_NAMEs: ABDI, REZA  (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;adaptive immunity;Adhesions;allograft rejection;Allografting;antagonist;Antigen Presentation;Biology;Blood Platelets;Blood Vessels;CD8-Positive T-Lymphocytes;Cell Communication;cell motility;Cell Surface Receptors;cell type;Cells;Cellular Immunity;Chronic;conditional knockout;cytokine;Data;Drug Delivery Systems;Encapsulated;Endothelial Cells;Engraftment;Extracellular Matrix;Family;Goals;Graft Rejection;heart allograft;Heart Diseases;Heart Transplantation;Immune;Immune Tolerance;Immunosuppressive Agents;Impairment;improved;Inflammation;inflammatory milieu;inflammatory modulation;Inflammatory Response;innovation;insight;Integrins;Interdisciplinary Study;isoimmunity;ITGB3 gene;Knockout Mice;Lesion;Mediating;Membrane Proteins;Methods;migration;mouse model;Mus;Nanodelivery;nanoparticle;Natural Immunity;new therapeutic target;novel;novel strategies;novel therapeutic intervention;optimal treatments;Organ;Organ failure;Organ Transplantation;Outcome;Pathogenesis;Patients;Perfusion;Periodicity;Play;prevent;recruit;Reperfusion Injury;response;RGD (sequence);Role;side effect;Signal Transduction;Site;T cell infiltration;T-Cell Activation;T-Lymphocyte;targeted delivery;Testing;Therapeutic;Time;trafficking;Transplant Recipients;Transplantation;Wild Type Mouse

PROJECT_TITLE: The novel role of beta3 integrin in regulating alloimmunity

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Esophageal Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Pancreatic Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_NAME: DANA-FARBER CANCER INST

PI_NAMEs: WOLPIN, BRIAN MATTHEW (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;arm;Biological Models;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;cancer epidemiology;cancer genetics;cancer genomics;cancer health disparity;Cancer Intervention;cancer risk;Catchment Area;cell free DNA;Cholangiocarcinoma;Clinical;Clinical Investigator;Clinical Trials;Collaborations;Colorectal;Colorectal Cancer;community engagement process;Complex;Computational Biology;Core Facility;Correlative Study;Dana-Farber Cancer Institute;design;Development;Diagnosis;Direct Costs;Discipline;Disease;Disparity population;Drug resistance;Early Diagnosis;early onset colorectal cancer;effective therapy;Emerging Technologies;Environmental Risk Factor;Epigenetic Process;Esophagus;ethnic disparity;Evaluation;Foundations;frontier;Functional disorder;Funding;gastroesophageal cancer;Genetic Models;genetic risk factor;Genetic study;genome-wide;genomic biomarker;Genomics;Goals;health disparity;Hepatobiliary;Heterogeneity;Immune;Immunooncology;Immunotherapy;immunotherapy clinical trials;improved;Incidence;Infrastructure;Institution;inter-institutional;Laboratories;Leadership;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Massachusetts;member;Methods;Mission;Modeling;Molecular;molecular imaging;molecular marker;Mutation;neoplastic cell;neuroendocrine cancer;new technology;new therapeutic target;novel;novel strategies;novel therapeutics;Oncology;Pancreas;Paper;Patients;Peer Review Grants;Pharmaceutical Preparations;Population;precision oncology;prevent;Prevention;Prevention strategy;Preventive;Primary carcinoma of the liver cells;programs;Publishing;racial disparity;Research;Research Personnel;Research Training;Resistance;resistance mechanism;response;Science;Scientist;screening;Screening for cancer;Stomach;Strategic vision;Structure;targeted treatment;Technology;Therapy Clinical Trials;tool;Translating;treatment response;tumor heterogeneity;tumor immunology;tumor microenvironment;underserved community;Work

PROJECT_TITLE: Program 32: Gastrointestinal Malignancies


NIH_SPENDING_CATS: Genetics;Human Genome;Rare Diseases

ORG_NAME: UNIVERSITY OF UTAH

PHR: Project Narrative Short tandem repeats (STRs) are repetitive DNA sequences that cause dozens of genetic diseases in humans and are difficult to sequence and interpret, leaving individuals with STR-associated disease undiagnosed. This proposal will establish a genetic diagnosis for hundreds of patients, while searching for new STR disease loci. To accomplish this, we will develop new computational approaches and call STRs across the genome in thousands of individuals to establish a population-scale STR catalog, with an emphasis on diverse and under- served populations.

PI_NAMEs: DASHNOW, HARRIET  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Address;Alleles;Catalogs;Child;cohort;Communities;contig;Data;Data Set;Databases;Detection;detection method;Diagnosis;Disease;disease diagnosis;DNA Sequence;Dropout;empowerment;Exclusion;experience;Frequencies;Funding;Future;Gene Expression;Gene Frequency;Gene Order;Genetic Diseases;genetic disorder diagnosis;Genome;genome sequencing;genome-wide;Genomics;Genotype;Hospitals;Human;human disease;Human Genome;Incidence;Individual;innovation;insertion/deletion mutation;Investigation;Medical Research;Methods;Mutation;nanopore;National Human Genome Research Institute;novel;Pathogenicity;Patients;Phenotype;Population;Population Heterogeneity;Rare Diseases;rare genetic disorder;Repetitive Sequence;Research;Research Personnel;Resources;Scheme;Short Tandem Repeat;Single Nucleotide Polymorphism;Stretching;Stuttering;Technology;Trans-Omics for Precision Medicine;Underserved Population;Universities;Untranslated RNA;Variant;Washington;whole genome;Work

PROJECT_TITLE: Revealing new short tandem repeat variation in the human population across sequencing technologies: towards rare disease diagnosis and discovery

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Lung;Lung Cancer;Prevention

PHR: Project Narrative Not Applicable.

PI_NAMEs: JOHNSON, BRUCE E. (contact)

PROJECT_TERMS: Acceleration;Address;Authorship;BRAF gene;cancer care;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Etiology;cancer genetics;cancer health disparity;cancer risk;cancer subtypes;career;Cellular biology;chemotherapy;Clinic;Clinical;clinical development;Clinical Research;Clinical Trials;Collaborations;Combination immunotherapy;community engagement;community engagement process;computed tomography screening;Dana-Farber Cancer Institute;Development;Diagnosis;Direct Costs;Discipline;DNA sequencing;Drug resistance;Early Diagnosis;Elements;Epidermal Growth Factor Receptor;Evolution;Faculty;frontier;Funding;Genetic Predisposition to Disease;Genomics;Goals;immune checkpoint blockade;Immunotherapeutic agent;Immunotherapy;improved;Infrastructure;innovation;insight;Institution;inter-institutional;Investigation;KRAS2 gene;Laboratories;Link;liquid biopsy;lung cancer screening;Malignant neoplasm of lung;Malignant neoplasm of thorax;Malignant Neoplasms;member;Mentors;Methods;minority investigator;Mission;Molecular Analysis;Mutation;new technology;next generation;novel therapeutic intervention;novel therapeutics;Oncogenes;Paper;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peer Review Grants;Pharmaceutical Preparations;Play;Population;Postdoctoral Fellow;preclinical study;Predisposition;Prevention;Preventive;Prognosis;programmed cell death ligand 1;programs;Publishing;Research;Research Personnel;Resistance;resistance mechanism;Resource Sharing;Resources;response;Role;ROS1 gene;Screening for cancer;Seminal;Signal Pathway;Signaling Molecule;single cell analysis;smoking cessation;social;Stains;Strategic Planning;Strategic vision;Structure;targeted agent;targeted treatment;Testing;Therapeutic Agents;Therapeutic Clinical Trial;Training;tumor;tumor DNA;tumor immunology;tumor microenvironment;Underrepresented Minority;Underserved Population;Vaccines

PROJECT_TITLE: Program 34: Lung Cancer


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: PROJECT NARRATIVE Obesity and associated metabolic disease, including type 2 diabetes, are a public health crisis; the risks of which are elevated in military Veterans. Although invasive, bariatric surgery is the most effective treatment for sustained weight loss, and it also improves glycemic control and other comorbidities in obese patients. This innovative research project will examine the novel role of intestinal-derived Fibroblast Growth Factor 15 (FGF15) in the regulation of body composition and glucose metabolism following bariatric surgery. The findings from these studies have high potential to identify new interventions in targeting obesity, metabolic disease, and for the preservation of lean mass and bone density after weight loss surgery.

PI_NAMEs: KRAMER, NADEJDA BOZADJIEVA (contact)

PROJECT_TERMS: absorption;Adult;Area;Award;Awareness;bariatric surgery;Basic Science;Bile Acid Biosynthesis Pathway;Bile Acids;Binding;Body Composition;Body Weight;Body Weight decreased;Bone Density;bone loss;bone mass;Caloric Restriction;Cardiovascular Diseases;career development;Caring;Cholesterol;Circulation;Clinical Research;Clinical Sciences;Communication;comorbidity;Complex;Data;Development;diagnostic tool;Diet;effective therapy;Enterocytes;Enterohepatic Circulation;Environment;Etiology;experience;farnesoid X-activated receptor;Fatty Liver;FGF19 gene;FGFR4 gene;Fibroblast Growth Factor;Foundations;Future;Gastrectomy;Genes;Glucose;Glucose Clamp;glucose metabolism;glucose production;glucose tolerance;glucose uptake;glycemic control;Goals;Greater curvature of stomach;Health;Healthcare;healthcare burden;Hepatic;Hormones;Human;human disease;Hydrophobicity;Hyperinsulinism;ileum;improved;In Vitro;in vivo Model;innovation;Insulin Resistance;Intervention;Intestines;Knockout Mice;Knowledge;Leadership;Ligands;lipid metabolism;Liver;liver ablation;Liver diseases;liver injury;liver metabolism;Mediator;Medical center;Mentors;Mentorship;Metabolic;Metabolic Diseases;metabolomics;Michigan;military veteran;Morbid Obesity;mouse model;Mus;muscle form;Muscular Atrophy;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;obese patients;Obesity;Operative Surgical Procedures;Organism;Orthologous Gene;Osteopenia;Overweight;Patient Selection;patient subsets;patient variability;Patients;pharmacologic;Physiological;Physiology;Plasma;Population;Postdoctoral Fellow;preclinical study;preservation;Prevalence;prevent;Production;programs;protective effect;Public Health;receptor;Receptor Signaling;Regulation;Research;research and development;Research Project Grants;Resources;response;Risk;Rodent Model;Role;Scientist;side effect;Signal Pathway;Signal Transduction;skills;Small Intestines;Testing;Therapeutic Intervention;Thinness;Toxic effect;Training;Training Activity;transcription factor;Travel;United States Department of Veterans Affairs;Universities;Venous;Veterans;weight loss intervention;Work

PROJECT_TITLE: The role of intestinal-derived FGF15/19 during obesity and rapid weight loss


ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Emphysema, a chronic and debilitating lung disease for which the primary risk factors are a prior history of cigarette smoking, male sex and advancing age, is commonly diagnosed in US Veterans. Histologically and functionally, emphysema is associated with loss of terminal lung alveoli which comprise alveolar epithelial cells, capillary endothelial cells and septal fibroblasts, the latter providing trophic and structural support to the alveolar epithelium. Little is known about the effects of cigarette smoke on fibroblasts or how this may affect the survival and function of the alveolar epithelium. This application seeks to address this fundamental knowledge gap and identify strategies to prevent lung tissue destruction in emphysema.

PI_NAMEs: RICHES, DAVID W. (contact)

PROJECT_TERMS: Ablation;Address;Affect;airway epithelium;Alveolar;alveolar epithelium;Alveolar wall;Apoptosis;Apoptotic;Attention;Award;BCL2 gene;Blood capillaries;Capillary Endothelial Cell;Cell Death;Cells;Chronic;Chronic lung disease;cigarette smoke;cigarette smoke-induced;Cigarette smoke-induced emphysema;cigarette smoking;Collagen;Development;Diagnosis;Disease;Elastin;Elderly;Endothelial Cells;Endothelium;Epithelial Cells;Event;exposure to cigarette smoke;Extracellular Matrix;Fibroblasts;Functional impairment;functional loss;gain of function;Gases;Genes;Genetic;genetic approach;Goals;Health;Heterogeneity;Histologic;Homeostasis;Impairment;Inhibition of Apoptosis;interstitial;Knowledge;Location;loss of function;Lung;lung development;Lung Diseases;lung injury;male;Mesenchymal;Methods;Microanatomy;Modeling;mouse model;Mus;Myofibroblast;novel;Pathogenesis;Pathologic;Pathway interactions;Pericytes;Phase;Phenotype;Platelet-Derived Growth Factor alpha Receptor;Play;Positioning Attribute;postnatal;prevent;Process;Pulmonary alveolar structure;Pulmonary Emphysema;Pulmonary Fibrosis;pulmonary function;Recording of previous events;Research;Respiratory Insufficiency;response;RIPK3 gene;Risk Factors;Role;sex;Structure of parenchyma of lung;Testing;Therapeutic;Thinness;Type II Epithelial Receptor Cell;Veterans

PROJECT_TITLE: Alveolar Septal Fibroblast Loss and The Pathogenesis of Emphysema


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Prevention;Skin Cancer

ORG_CITY: BOSTON

PI_NAMEs: HODI, FRANK S (contact)

PROJECT_TERMS: 18 year old;Acceleration;Address;Affect;anti-CTLA4;anti-PD-1;Basic Science;Behavior;Biological;Biology;Biopsy;BRAF gene;Cancer Center;Cancer Center Support Grant;cancer risk;carcinogenicity;Catchment Area;Cells;checkpoint inhibition;Child;Clinical;Clinical Investigator;Clinical Trials;Collaborations;Communities;Core Facility;Coupled;Dana-Farber Cancer Institute;Diagnosis;Direct Costs;Disease;Epigenetic Process;epigenomics;Foundations;Funding;Genetic Transcription;Genome;Genomics;Goals;Immune;immune checkpoint;Immune Targeting;Immunology;improved;Institution;inter-institutional;International;Journals;Knowledge;Laboratories;Leadership;Malignant Neoplasms;Massachusetts;Medical Oncologist;Medicine;Melanoma;Melanoma patient;Melanoma Tumor;melanomagenesis;member;Metabolic;metabolomics;Mission;Molecular;Molecular Evolution;Nature;Neoplasm Metastasis;New England;novel;Outcome;Paper;Patients;Peer Review;Peer Review Grants;Play;pre-clinical;Pre-Clinical Model;preclinical study;Prevention;programs;Publications;Publishing;Reporting;Research;Research Personnel;Resistance;resistance mechanism;Resources;Risk;Role;Sampling;Science;Seminal;Shapes;Signal Transduction;Skin Cancer;Skin tanning;Specimen;standard of care;Statutes and Laws;Structure;Surgical Oncologist;targeted treatment;Technology;Therapeutic;Toxic effect;Training;Training and Education;Translating;Translations;treatment optimization;treatment response;tumor;Tumor Bank;tumor microenvironment;tumor progression

PROJECT_TITLE: Program 35: Melanoma


ORG_CITY: SAN ANTONIO

ORG_NAME: SOUTH TEXAS VETERANS HEALTH CARE SYSTEM

PHR: Aging-related bone degeneration is a major healthcare challenge for America's growing population of aging Veterans. Changes in bone mass and structure occur with age and are common in both women and men, resulting in increased risk for debilitating pain, bone fracture, and delayed healing. With aging, resident stem cells in bone lose their ability to maintain the tissue and bone degeneration takes place over time. My preliminary results suggest that during aging, the level of a protein, Cyr61 (also known as CCN1), becomes depleted in bone. The proposed research will investigate this protein and determine if it's required for normal function of bone-specific stem cells and whether replenishing it during aging restores their function in bone. The results gained from this study may provide a novel approach for reversing bone degeneration during aging or stimulating bone repair after injury.

PI_NAMEs: MARINKOVIC, MILOS  (contact)

PROJECT_TERMS: Address;Adenoviruses;Age;age related changes;Aging;aging mechanism;aging related;aging related disease;Animals;Binding;Bioinformatics;Biology of Aging;BMP2 gene;bone;Bone Density;bone fracture repair;bone healing;bone loss;Bone Marrow;bone mass;Bone Matrix;bone repair;Bone structure;career development;cell behavior;Cells;collagen scaffold;comorbidity;Cues;Data;debilitating pain;Dose;Exhibits;Experimental Designs;Extracellular Matrix;Fifth lumbar vertebra;Fracture;Gene Transfer;Genes;Genetic Engineering;Growth Factor;Harvest;Health;Healthcare;Histology;Immunohistochemistry;Impaired healing;Implant;implantation;improved;In Vitro;in vivo Model;Injury;innovation;Insulin-Like Growth Factor I;knock-down;Knockout Mice;Knowledge;Laboratories;Lateral;Lead;Maintenance;Measures;men;Mentors;Mesenchymal Stem Cells;Methods;Morbidity - disease rate;Mus;Natural regeneration;novel;novel strategies;novel therapeutic intervention;old mice;Operative Surgical Procedures;osteoblast differentiation;Osteoblasts;Osteogenesis;osteogenic;Osteoporosis;osteoprogenitor cell;Phenotype;Population;Predisposition;Production;Protein Dephosphorylation;Proteins;Proteome;Proteomics;radiological imaging;recombinant human bone morphogenetic protein-2;regenerative;Reporting;Research;Research Personnel;response;Risk;Role;side effect;skeletal;skills;Small Interfering RNA;Spinal Fractures;Spinal Fusion;stem cell growth;stem cell niche;stem cells;stemness;Stromal Cells;System;Testing;Time;Tissues;tomography;translational potential;Veterans;Western Blotting;Woman;wound

PROJECT_TITLE: Role of Cyr61/CCN1 in Mesenchymal Stem Cell Niche and Aging Bone


ORG_CITY: EAST ORANGE

ORG_NAME: VA NEW JERSEY HEALTH CARE SYSTEM

PHR: Airborne- and droplet-transmitted diseases are common during military deployments. Developing efficacious vaccines against infectious diseases is thus essential for protecting troops in service as well as veterans. Our proposed study directly addresses this need, by advancing the understanding of TFH cells at new frontiers, i.e., elucidating differential requirements for costimulation signals by immunization and viral infection, and connecting costimulation signals, nuclear factors, chromatin and transcriptomic changes with TFH functions. We expect to yield essential information on tailoring TFH activity to provide optimal B cell help, and hence provide paradigm-shifting rationales for enhancing vaccine design.

PI_NAMEs: XUE, HAI-HUI  (contact)

PROJECT_TERMS: Acute;acute infection;Address;Antibody Affinity;Antibody Formation;Antibody Response;ATAC-seq;Attention;Attenuated;B-Lymphocytes;BACH2 gene;Belief;CD28 gene;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Maturation;Cell Physiology;Chromatin;Communicable Diseases;Data;design;disease transmission;extracellular;frontier;Funding;Gene Expression Regulation;Generations;Genetic;Genetic Complementation Test;Genetic Transcription;Genome;Genomics;Helper-Inducer T-Lymphocyte;Immunity;Immunization;Immunologic Memory;improved;in vivo;Infection;Knowledge;LoxP-flanked allele;Maps;Memory;Memory B-Lymphocyte;Military Personnel;Molecular;mutant;Mutant Strains Mice;Mutation;NF-kappa B;Nuclear;nuclear factors of activated T-cells;Organism;Output;Pathway interactions;PDPK1 gene;Phase;PIK3CG gene;Plasma Cells;Proteins;receptor;response;Role;Route;Services;Signal Transduction;single-cell RNA sequencing;SOX4 gene;Specific qualifier value;Stimulus;Structure of germinal center of lymph node;Testing;transcription factor;transcriptome sequencing;transcriptomics;Vaccination;vaccine delivery;Vaccine Design;vaccine efficacy;Vaccines;Veterans;Viral Proteins;Virus;Virus Diseases

PROJECT_TITLE: Modulating costimulation pathways to improve follicular helper T cell and antibody responses


NIH_SPENDING_CATS: Cancer;Immunotherapy;Kidney Disease;Orphan Drug;Prevention;Rare Diseases

PI_NAMEs: CHOUEIRI, TONI  (contact)

PROJECT_TERMS: Address;American Society of Clinical Oncology;antagonist;anti-cancer research;anti-PD-1/PD-L1;Award;Basic Science;bevacizumab;Biological;Biology;Cancer Center;Cancer Center Support Grant;cancer infiltrating T cells;cancer prevention;Catchment Area;Cells;Classification;Clear cell renal cell carcinoma;clinical development;Clinical Trials;Collaborations;Combined Modality Therapy;community engagement process;Community Health Education;Core Facility;CTLA4 gene;Dana-Farber Cancer Institute;Development;Direct Costs;Disease;disparity reduction;drug development;early detection biomarkers;Early Diagnosis;effective therapy;Ensure;EZH2 gene;Funding;Future;genetic signature;Goals;Grant;Immunologics;improved;Incidence;Infrastructure;inhibitor;innovation;Institution;inter-institutional;International;Kidney Neoplasms;Malignant Neoplasms;Massachusetts;Medicine;member;Mission;Molecular;Nature;New Agents;new therapeutic target;Nivolumab;Nobel Prize;novel;Oxygen;Paper;Pathway interactions;Patient-Focused Outcomes;Patients;PD-1 blockade;Peer Review Grants;pembrolizumab;phase I trial;phase II trial;phase III trial;Phenotype;Play;Population;Positioning Attribute;Pre-Clinical Model;predictive marker;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;programs;Publishing;Randomized;Renal Carcinoma;Research Personnel;Research Training;Rewards;Role;Seminal;Series;Signal Transduction;standard of care;Strategic Planning;Structure;Surrogate Markers;symposium;System;Testing;Training;Training and Education;treatment response;tumor;Validation;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Program 52: Kidney Cancer