NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The aims of this proposal are to determine the safety and efficacy of Cannabidiol (CBD) to alleviate pain and opioid craving among people living with both opioid addiction and chronic pain. Results will provide evidence as to whether CBD might aid as a novel treatment for this especially vulnerable population. This proposal will accelerate the development of novel therapeutics targeting the endogenous cannabinoid system for opioid addiction and chronic pain, a strategy that is likely to reduce persistently high rates of relapse and save lives.

PI_NAMEs: DE AQUINO, JOAO PAULO (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: abuse liability;Acceleration;Acute;addiction;Adverse effects;Adverse event;Analgesics;Animals;antinociception;Behavior;Behavioral Paradigm;behavioral pharmacology;Biological Markers;Biometry;Board Certification;Brief Pain Inventory;Cannabidiol;Cannabinoids;career;chronic pain;Clinical;clinical training;Clinical Trials;cognitive testing;Collaborations;comorbidity;computerized;Connecticut;craving;Cue-induced relapse;Cues;Data;Death Rate;Development;Dose;drug testing;DSM-V;endogenous cannabinoid system;Enrollment;Foundations;Goals;Grant;hedonic;Heroin;Hour;Human;indexing;Institution;Laboratory Study;Link;Maintenance;Measures;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Methadone;Methods;Morbidity - disease rate;multimodality;National Institute of Drug Abuse;new therapeutic target;non-cancer chronic pain;novel;novel therapeutics;Opiate Addiction;Opioid;Opioid agonist;opioid agonist therapy;opioid treatment program;opioid use;opioid use disorder;Oral;Outcome;Outcome Study;overdose death;Pain;Pain management;Pain Measurement;pain reduction;Pain Research;pain sensitivity;Participant;patient population;Patient Self-Report;Patients;performance tests;Persons;Pharmaceutical Preparations;Pharmacotherapy;Placebo Control;Placebos;Population;Positioning Attribute;preclinical study;programs;Property;Psychiatrist;Questionnaires;Randomized;Relapse;Research;Research Training;Resources;response;responsible research conduct;Safety;safety assessment;safety study;Self Administration;Sensory;Severities;Sex Differences;skills;symposium;Techniques;Testing;Therapeutic;therapeutic biomarker;Time;Training;Treatment Efficacy;treatment response;Urine;Verbal Learning;Visual;Vulnerable Populations;Work;Writing

PROJECT_TITLE: Cannabidiol Pharmacotherapy for Comorbid Opioid Addiction and Chronic Pain

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Narrative: Social stress in humans increases the risk for depression resulting in anhedonia—a loss of interest in pleasurable stimuli—which can manifest within social domains and lead to severe social impairments. Mouse models of social stress are useful to better understand the biological underpinnings of stress-impaired social behavior deficits. Our results show that activation of lateral septum in susceptible mice following social defeat occludes social reward and preference promoting social avoidance behavior.

PI_NAMEs: RUSSO, SCOTT JAMES (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Adolescent;Adult;Anhedonia;avoidance behavior;Behavior;Behavioral;Biological;Biological Assay;Brain;brain circuitry;brain dysfunction;Brain region;bullying;cell type;Chronic;Complex;conditioned place preference;Cues;Data;Development;Diagonal Band Nucleus;Dissection;experience;Feeling;Female;Fiber;FOS gene;Fright;gamma-Aminobutyric Acid;Genetic;Histologic;Human;Image;Impairment;In Situ Hybridization;in vivo;interest;Lateral;Link;male;Maps;Measures;Mediating;Mental Depression;Modeling;Molecular;Motivation;mouse model;Mus;neural;neural circuit;Neurons;neuropsychiatry;Neurotensin;novel;Nucleus Accumbens;optogenetics;Pattern;Photometry;Physiological;Population;Predisposition;preference;prevent;Property;Reaction;Research;resilience;response;reward circuitry;Rewards;Risk;Rodent;Rodent Model;Role;Same-sex;Signal Transduction;Slice;social;Social Behavior;Social Conditions;Social Controls;social defeat;Social Interaction;Social isolation;social stress;Stimulus;Stress;Syndrome;Testing;Time;tool;Viral;Work

PROJECT_TITLE: Neural Circuit Mechanisms of Stress-Impaired Social Reward

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Microbiome;Neurosciences;Nutrition

ORG_CITY: OMAHA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA OMAHA

ORG_STATE: NE

PHR: PROJECT NARRATIVE This research will aim to establish the connection between antibiotic use, activity of gut bacteria, and depression, with the long-term goal of finding new therapeutic options to treat neuropsychiatric diseases. The training plan will allow the trainee to gain new skills to study if and how antibiotic use leads to depression.

PI_NAMEs: CLAYTON, JONATHAN BRENT (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Anhedonia;Animal Model;animal model development;anti-depressive agents;Antibiotic Therapy;Antibiotics;antimicrobial;bacterial metabolism;Behavior;Behavioral;Biological;Brain;Callithrix;Callithrix jacchus jacchus;Clinical Research;Clinical Treatment;Communication;Complex;Control Groups;cytokine;Data;Data Analyses;depressive behavior;depressive symptoms;design;Desire for food;Development;dietary;Disease;dysbiosis;Endocrine;epidemiology study;Event;Extramural Activities;fecal transplantation;Fluoxetine;Funding;Goals;gut bacteria;gut dysbiosis;gut microbes;gut microbiome;gut microbiota;gut-brain axis;Hormones;Human;Hydrocortisone;Immune;Immune system;Inflammatory;inflammatory marker;Intervention;Knowledge acquisition;Life;Measures;Mental Depression;Mentored Research Scientist Development Award;Mentorship;Metabolic;metabolomics;microbiome;microbiome composition;microbiota-gut-brain axis;Modeling;Morbidity - disease rate;Multiomic Data;Neomycin;Nervous System Disorder;Neurobiology;neuropsychiatric disorder;Neurosecretory Systems;nonhuman primate;novel;novel therapeutics;Pathologic;Patients;Persons;Physiological;Population;Predisposition;prevent;Probiotics;Production;Research;Research Personnel;Risk;Rodent Model;Role;Signal Pathway;skills;Social Characteristics;Social Controls;Social isolation;social separation;stressor;Study models;symptomatology;Testing;Therapeutic;Therapeutic Effect;Training;translational model;Vancomycin;vocalization

PROJECT_TITLE: A Model of Antibiotic-induced Gut Dysbiosis and Depressive Symptomatology


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Conditions Affecting the Embryonic and Fetal Periods;Congenital Heart Disease;Congenital Structural Anomalies;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Heart Disease;Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Substance Misuse

ORG_CITY: CLEVELAND

ORG_DEPT: PEDIATRICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Abnormal blood flow has been shown to play a role in the formation of congenital heart defects (CHDs). However, few tools exist to study how forces exerted by blood flow early in heart development result in altered molecular signaling. Our proposal centers on creating optical imaging to investigate mechanical stresses experienced by cells lining the beating, early-stage heart tube and how these cells and adjacent tissues respond in gene expression in each area of the heart during normal, diseased, and rescued conditions.

PI_NAMEs: JENKINS, MICHAEL W. (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: 3-Dimensional;addiction;Affect;Algorithms;Area;Betaine;Biological Process;Blood flow;Cardiac;cardiogenesis;Cardiovascular Diseases;Cell Line;Cell Shape;cell type;Cells;Cohort Studies;Computer software;Congenital Heart Defects;Data;deep learning;detection method;Development;Diffusion;DiGeorge Syndrome;Disease;disease model;Early Diagnosis;Embryo;Embryonic Heart;experience;experimental study;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fluorescent in Situ Hybridization;Funding;Gene Expression;Gene Expression Profile;Genetic;Glutathione;Heart;heart function;hemodynamics;Histology;Image;image processing;Imaging Device;Immunohistochemistry;improved;In Situ;in situ sequencing;indexing;Knowledge;Link;Malignant Neoplasms;Maps;Measurement;Measures;Mechanical Stress;Methods;Modeling;Molecular;Morbidity - disease rate;Morphology;Nervous System Disorder;novel;Optical Coherence Tomography;optical imaging;Optics;parallelization;Pathway interactions;Pattern;Positioning Attribute;prevent;Prevention;Productivity;Protocols documentation;Quail;Reporting;RNA;Role;Sequencing By Hybridizations;shear stress;Signal Transduction;Specificity;statistics;Structure;System;Testing;Tissues;tool;Tube;virtual;Visualization;Work

PROJECT_TITLE: Optical Tools to Assess the Role of Cardiac Function in the Development of Congenital Heart Defects

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative  Insight into transcription elongation mechanisms will be sought through studies of RNA polymerase pausing and transcription termination in Bacillus subtilis and Escherichia coli. Proper regulation of gene expression is of paramount importance for the function of cells in all organisms. As several human diseases arise in part through inappropriate gene expression, these studies will contribute to improving human health by providing a detailed mechanistic understanding of how transcription elongation is controlled.

PI_NAMEs: BABITZKE, PAUL L (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 5' Untranslated Regions;Active Sites;Affect;Bacillus subtilis;Bacteria;Base Pairing;Binding;Biological Assay;Biological Models;Cell Physiology;Collaborations;Computer Analysis;Coupling;Cryoelectron Microscopy;Data;Digestion;DNA;DNA-Directed RNA Polymerase;Elements;Escherichia coli;Event;Exhibits;Factor Analysis;flexibility;follow-up;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genome-wide;Genomics;Health;Human;human disease;improved;In Vitro;in vivo;insight;interest;Maps;Mediating;Methods;Modeling;Open Reading Frames;Organism;Pancreatic ribonuclease;Play;Positioning Attribute;Prevalence;Process;promoter;Proteins;Regulation;response;rho;RNA;RNA analysis;RNA Folding;Role;Side;Sigma Factor;Signal Transduction;Site;stem;termination factor;Testing;Time;Transcript;Transcription Elongation;transcription termination;Transcriptional Elongation Factors;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Translations;Visualization;Work

PROJECT_TITLE: Regulation of transcription elongation

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: Fairfax

ORG_NAME: INOVA HEALTH CARE SERVICES

ORG_STATE: VA

PHR: PROJECT NARRATIVE The Heart Failure Collaboratory (HFC) is a public-private partnership between the Inova Heart and Vascular Institute (IHVI), the United States Food and Drug Administration (FDA), and the major stakeholders in the heart failure (HF) community whose mission is to advance scientific discussion and improve efficiency of clinical trials and evidence generation for HF by fostering a collaborative environment in which all stakeholders can interact to optimize innovation and advancement of new therapeutic products. HFC deliverables provide recommendations, structures, definitions, and mechanisms for all individuals, companies, or organizations to use for the development of new therapies for patients with HF.

PI_NAMEs: O'CONNOR, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: PEASE-FYE, MEG

PROJECT_TITLE: The Heart Failure Collaboratory Public-Private Partnership Between the United States Food and Drug Administration, the Inova Heart and Vascular Institute, and the Heart Failure Community


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: This study will improve access of Veterans with epilepsy living in rural areas to the most important diagnostic procedure for the care of patients with epilepsy: the routine electroencephalogram (EEG). We will test a new method for recording EEG which uses a novel dry electrode system headset that does not require an EEG technologist to operate. The headset integrates the EEG electrodes and amplifier into a compact system which is easily placed on the head. This approach could make it possible for a nurse or nurse assistant with minimal training to record an EEG in a rural community based outpatient clinic (CBOC) as part of an epilepsy telemedicine outreach program along with clinical interviews. We will compare performance of this dry electrode system to standard EEG when it is used by EEG technologists in three VA medical centers. This project has the potential to improve access of Veterans to the EEG procedure and decrease cost to the Veterans Health Care System.

PI_NAMEs: HALFORD, JONATHAN JACOB (contact)

PROJECT_TERMS: Address;Ambulatory Care Facilities;Amplifiers;Appointment;Blinded;Board Certification;Caring;Clinic;Clinical;Clinical Trials;Communities;Computer software;cost;Cost Savings;Costs and Benefits;Data;Devices;Diagnostic Procedure;Discipline of Nursing;Dryness;Electrodes;Electroencephalography;Epilepsy;epileptiform;Equipment;Equipment and Supplies;Evaluation;Event;FDA approved;Head;Health Services Accessibility;Healthcare Systems;Hour;Improve Access;improved;innovation;Internet;Interview;Location;Measures;Medical center;Methodology;Methods;Minor;Mission;Modality;Morphologic artifacts;Neurologic;Neurologist;novel;Nurses;Outpatients;outreach program;Patient Care;Patients;Pattern;Performance;Preparation;Probability;procedure cost;Procedures;prospective;Randomized, Controlled Trials;Recording of previous events;recruit;remote location;Research;Research Personnel;Research Priority;Research Proposals;Research Subjects;rural area;Rural Community;Rural Health;rural residence;Schedule;Seizures;Signal Transduction;Site;Skin;System;telehealth;Telemedicine;Testing;Time;Training;transmission process;Travel;Veterans;Visit;Wages;Wait Time

PROJECT_TITLE: Testing a Novel Dry Electrode Headset for Electroencephalography Telehealth

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: HANOVER

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Disrupted social cognition is a risk factor, core symptom, and maintenance factor for most major mental illnesses, including autism, schizophrenia, and depression. At their core, these disruptions involve biases in if and how social information is perceived, a process that also varies across individuals in the normative population. The proposed research will determine the behavioral and neural mechanisms that underlie how different individuals can perceive the same social information in different ways, and identify novel intervention and treatment targets for biased social cognition in mental illness.

PI_NAMEs: FINN, EMILY SUZANNE (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Address;Affect;Algorithms;animation;autism spectrum disorder;Basic Science;Behavior;Behavior Therapy;Behavioral;Behavioral Mechanisms;Belief;Brain;Case Study;causal model;Cognition;Cognitive;Complex;Data;Diagnostic;Disease;Dissociation;Dose;Educational process of instructing;Etiology;experimental study;Exposure to;fighting;Functional Magnetic Resonance Imaging;gaze;Goals;Heterogeneity;Human;Individual;Individual Differences;individual variation;individuals with autism spectrum disorder;information processing;innovation;insight;Intervention;Intuition;Life;Light;Link;Maintenance;Major Mental Illness;Mental Depression;Mental disorders;mentalization;Modeling;Motion;National Institute of Mental Health;Nature;negative affect;neural;neurofeedback;neuroimaging;neuromechanism;novel;novel diagnostics;Outcome;Paranoia;Paranoid psychosis;Paranoid Schizophrenia;Pathology;patient population;Pattern;Perception;Personality Traits;Persons;Phenotype;Play;Population;prevent;Process;Property;Psychophysics;Reaction;Reading;Reporting;Research;Risk Factors;Sampling;Schizophrenia;Sensory;Shapes;social;social bias;social cognition;Social Functioning;Social Interaction;Social Perception;Stimulus;Strategic Planning;Symptoms;targeted treatment;Testing;Time;tool;trait;Variant;Visual;visual tracking;Work

PROJECT_TITLE: Modeling and manipulating social percepts in individuals


ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Abdominal aortic aneurysm is a major vascular disease in the United States, but current treatment relies on detection, monitoring, lifestyle changes, and surgery. Very little is known about the molecular mechanisms contributing to aneurysm rupture, a highly lethal complication among aneurysm patients. The proposed research aims to investigate how thrombospondin-1 coordinates the vascular responses that drive or protect aneurysm growth and rupture, which will facility therapeutic development for aortic aneurysm.

PI_NAMEs: LIU, BO  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Abdominal Aortic Aneurysm;Actins;Address;Adoptive Transfer;Affect;Aneurysm;Angiotensin II;Animals;Aorta;Aortic Aneurysm;Aortic Rupture;Apoptotic;Area;Atherosclerosis;atherosclerotic plaque rupture;beta Aminopropionitrile;Blood Vessels;Bone Marrow;Breeding;CD47 gene;Cells;Clinical;Complication;conditional knockout;Coupled;Data;Deoxyribonuclease I;Detection;Development;Dilatation - action;Elastases;extracellular;Female;Gene Deletion;Growth;Human;human disease;hypercholesterolemia;Imipramine;Immunohistochemistry;Impairment;In Situ Hybridization;Incidence;induced pluripotent stem cell;Infiltration;Inflammation;Infusion procedures;inhibitor;knock-down;Knock-out;Knockout Mice;Knowledge;Life Style;Low-Density Lipoproteins;LoxP-flanked allele;Macrophage;male;Mediating;migration;Modeling;Molecular;Molecular Profiling;Monitor;mortality;mouse model;Mouse Strains;Mus;neutrophil;novel;Operative Surgical Procedures;Patients;Phagocytosis;Phenotype;Play;polymerization;Polymers;Preventive;Proteins;Publications;receptor;Reporting;Research;response;Role;Rupture;Ruptured Abdominal Aortic Aneurysm;Ruptured Aneurysm;single-cell RNA sequencing;Small Interfering RNA;Source;spatial relationship;System;Telemetry;Testing;THBS1 gene;therapeutic development;Thrombospondin 1;Tissues;ultrasound;United States;uptake;Vascular Diseases

PROJECT_TITLE: Novel Role of Thrombospondin-1 in Protection against Rupture of Abdominal Aortic Aneurysm

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-D(02)M]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Palliative Care;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative X Implantable cardioverter-defibrillators (ICDs) are commonly used in older patients with multiple co-morbidities. This project will use a multi-center cohort study to prospectively define patient-centered experiences of older patients following ICD implantation. We then apply these data to the shared decision-making process with individualized decision tools, evaluating the feasibility of a precision approach to ICD use.

PI_NAMEs: KRAMER, DANIEL BRUCE (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Advance Care Planning;Area Under Curve;Arrhythmia;Cardiac Electrophysiologic Techniques;Cardiovascular system;Caring;Cessation of life;Clinic;Clinical;Clinical Trials;Cognition;cohort;Cohort Studies;Collaborations;Colorado;comorbidity;cost estimate;Data;Devices;Elderly;Electronic Health Record;Enrollment;evidence base;experience;Foundations;frailty;functional status;Geriatric Assessment;Geriatrics;Goals;Guidelines;health service use;Health Status;Heterogeneity;hospice environment;human old age (65+);Impaired cognition;Implant;Implantable Defibrillators;implantation;Implantation procedure;implementation strategy;impression;improved;individual patient;instrumental activity of daily living;Interview;Knowledge;Maps;Measures;Medicare;Methods;Modeling;mortality;novel;older adult;older patient;Older Population;Outcome;outcome prediction;Outcomes Research;patient oriented;Patients;Performance;personalized approach;personalized decision;personalized predictions;Persons;Physical activity;Pilot Projects;predictive modeling;preference;Probability;Procedures;Process;prospective;Prospective cohort;Prospective Studies;prototype;Quality of life;Recording of previous events;recruit;remote monitoring;Research;Research Personnel;Resources;Risk;shared decision making;Shock;Site;Statistical Models;Structure;Symptom Burden;Telephone;tool;Translating;treatment effect;Treatment outcome;trial enrollment;Validation;Vulnerable Populations;Work

PROJECT_TITLE: The Trajectories and Clinical Experiences of ICD Therapy (TRACER-ICD) Study

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Lupus;Rheumatoid Arthritis

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: Macrophages have been implicated in several autoimmune diseases, including rheumatoid arthritis (RA), lupus kidney disease, and macrophage activation syndrome. The long term goals of this project are to understand how inflammatory macrophage activation (and de-activation) are regulated, and to use this knowledge to develop new therapies. This project will focus on understanding regulation of macrophage genes and pathways that play a key role in increasing inflammatory responses to gain knowledge that can be used to turn off macrophages to effectively and safely treat autoimmune and inflammatory diseases.

PI_NAMEs: IVASHKIV, LIONEL B (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Aftercare;Anti-Inflammatory Agents;Antigen Presentation;antimicrobial;Arthritis;Autoimmune Diseases;autoinflammatory diseases;Cells;Chromatin;chromatin remodeling;Clinical;cytokine;Data;Disease;Enhancers;Epigenetic Process;epigenome;familial hemophagocytic lymphohistiocytosis;FDA approved;Gene Expression;gene induction;Genes;Genetic Transcription;Goals;Histone Acetylation;Host Defense;Human;IL6 gene;Immune;Immunity;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;inhibitor;inhibitor therapy;insight;Interferons;Interleukin-1;Interleukin-10;Interleukin-6;Kidney Diseases;Knowledge;Literature;Lupus;Lupus Nephritis;Macrophage;Macrophage Activation;Macrophage activation syndrome;Measures;Mediating;Mendelian disorder;Molecular;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathogenicity;Pathway interactions;patient response;Patients;Play;Pre-Clinical Model;preservation;Production;promoter;Refractory;Regulation;Resistance;response;Rheumatism;Rheumatoid Arthritis;Role;Signal Induction;Signal Pathway;Signal Transduction;success;Systemic Lupus Erythematosus;targeted treatment;Testing;Therapeutic;therapeutic target;Tissues;TNF gene;transcription factor;Treatment Efficacy;Viral

PROJECT_TITLE: Activation of Macrophages in Human Autoimmune Diseases

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: The question of resident stem cell specification, maintenance, and homeostasis is both broad and important: In addition to furthering our basic understanding of how adult stem cells interact with their host tissues for optimum performance throughout life, this research may suggest interventions that would lessen the age- related decline in stem cell efficiency and number that occurs in many critical tissues, including muscle. The impairment of aged skeletal muscle regeneration leads to structural (fibrosis), biochemical and physiological deficits in muscle function that culminate in reduced physical activity, frailty, and the progressive decline in the health of the aged. Importantly, the proposed research has the potential to identify extrinsic and intrinsic factors that stimulate muscle SC proliferation and/or fate decision, which is both consistent with current theories on age-related decline in muscle regeneration, and a feasible avenue for potential therapy development against muscle degenerative disease, and to restore muscle after sport and/or combat injury.

PI_NAMEs: LEPPER, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Ablation;Adolescent;Adult;adult stem cell;Affect;age related;age related decline;age-related muscle loss;aged;Aging;Athletic Injuries;Back;Binding Sites;Biochemical;Birth;Cell Communication;Cell Count;Cell Maintenance;Cell Nucleus;Cell Proliferation;Cell Therapy;Cellular biology;ChIP-seq;combat injury;Data;Defect;Degenerative Disorder;Development;Disease;Dominant-Negative Mutation;Embryonic Development;Endowment;Exercise;experimental study;Feeds;FGF2 gene;FGF6 gene;FGFR1 gene;FGFR4 gene;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Fibrosis;frailty;Gene Expression Profiling;Genetic;Genetic Transcription;Goals;Growth;Health;Home;Homeostasis;Impairment;Injury;insight;Intervention;Intrinsic factor;knock-down;Knockout Mice;Knowledge;Life;Ligands;Maintenance;Mediating;Mediator;Medical;meetings;Molecular;mouse model;Mus;Muscle;muscle aging;Muscle Cells;Muscle Fibers;Muscle function;muscle progenitor cell;muscle regeneration;muscle repair;Muscle satellite cell;Muscular Atrophy;Mutagenesis;mutant;Mutant Strains Mice;Natural regeneration;overexpression;Paracrine Communication;paralogous gene;Pathway interactions;Performance;Perinatal;perinatal period;Physical activity;Physiological;Play;Population;precursor cell;Process;progenitor;Proliferating;Property;Proteins;reconstitution;regeneration potential;regenerative;Regenerative capacity;regenerative cell;Regulation;repaired;Research;Research Proposals;response;Role;sarcopenia;self-renewal;Signal Transduction;Skeletal Muscle;skeletal muscle differentiation;Skeletal Muscle Satellite Cells;Source;Specific qualifier value;Sports;stem cell fate specification;stem cells;stemness;Testing;theories;therapy development;Tissues;tool;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Transgenic Organisms;Trauma;trend;Wasting Syndrome;Work

PROJECT_TITLE: Regulation of Muscle Stem Cell Number via Paracrine Signaling

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Health Services;Hematology;Patient Safety;Stroke

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Harm resulting from drug-drug interactions is almost always preventable, yet many nursing home residents are at increased risk due to the number of medications they take, along with physiologic and clinical factors placing them at increased risk. I propose a series of interrelated aims to quantify the prevalence and consequences of drug-drug interactions involving direct-acting oral anticoagulants among nursing home residents. This work will not only generate valuable knowledge in its own right, but also allow for the implementation of policies to optimize drug use and improve outcomes among this vulnerable population.

PI_NAMEs: MEHTA, HEMALKUMAR B. (contact)

PROJECT_TERMS: ABCB1 gene;adverse outcome;Affect;age related;Aging;anti-epileptic agents;Anticoagulants;Antithrombin III;Atrial Fibrillation;Blood;care outcomes;career;Clinical;Clinical Pharmacology;clinically significant;computerized;cost;Crossover Design;CYP3A4 gene;Cytochrome P450;Data;Data Set;detection platform;Development;Drug Interactions;Drug Kinetics;Drug usage;Economics;Elderly;Electronic Health Record;Elements;Enzymes;Epidemiology;experience;expiration;Exposure to;Fostering;Foundations;Geriatrics;Goals;Growth;Health system;Hemorrhage;Home Nursing Care;Hospitalization;improved;improved outcome;inhibitor;Institution;K-Series Research Career Programs;Knowledge;Legal patent;Link;Logistic Regressions;Long-Term Care Nursing;Lovastatin;Marketing;Medicare;Medicare Part A;Mentored Research Scientist Development Award;Mentors;Mentorship;Metabolism;Methods;Modeling;Monitor;novel;Nursing Homes;older adult;Oral;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacokinetics and pharmacodynamics;Physicians;Physiological;point of care;Policies;Polypharmacy;Population;Prevalence;Probability;professor;Provider;Public Health;Public Health Schools;Quality of Care;Renal function;Research;Research Project Grants;Risk;Risk Reduction;Safety;Scientist;Series;Simvastatin;skill acquisition;skills;Stratification;Stroke;stroke risk;System;Techniques;therapeutic effectiveness;Thrombin;thromboembolic stroke;Time;tool;Training;United States;Verapamil;Vulnerable Populations;Warfarin;Work

PROJECT_TITLE: Drug-Drug Interactions Involving Direct-Acting Oral Anticoagulants in Nursing Home Residents

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MEMPHIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: The mortality rates associated with many invasive fungal infections remain disturbingly high, despite the appropriate use of three major classes of antifungal drug. Recently we found that many medications approved for human use can induce resistance to first-line antifungal drugs, suggesting their coadministration may undermine the clinical efficacy of antifungal therapy. Ultimately the findings of the proposed studies will be used to guide the selection of drug regimens and develop treatment protocols that maximize antifungal efficacy, to improve outcomes for patients with life-threatening fungal infections.

PI_NAMEs: PALMER, GLEN  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Affect;antagonist;anti-fungal agents;Antifungal Therapy;Antipsychotic Agents;aripiprazole;Aspergillus;Aspergillus fumigatus;Azoles;Biological;Biological Assay;Candida;Candida albicans;Candida glabrata;Candidiasis;Cause of Death;Chemicals;Clinical;clinical efficacy;clinically relevant;Collection;comorbidity;Cryptococcus;Cryptococcus neoformans;Death Rate;drug distribution;Drug Efflux;Drug Interactions;efflux pump;Enzymes;Exhibits;Failure;FDA approved;Fluconazole;follow-up;Frequencies;Fungal Drug Resistance;Gene Expression Profile;Goals;Growth;Human;Immune System Diseases;improved;improved outcome;In Vitro;Incidence;Individual;Infection;insight;Investigation;Life;Medical;Molecular;mortality;mouse model;Mucous Membrane;Mus;Mycoses;off-patent;Outcome;pathogenic fungus;patient response;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Physiology;Polyenes;Population;Predisposition;Regimen;Resistance;Retrospective cohort study;Risk;Severities;Site;subcutaneous;success;Testing;Therapeutic;Toxic effect;Treatment Failure;Treatment outcome;Treatment Protocols;Virulence

PROJECT_TITLE: Antifungal antagonism as a cause of treatment failure for invasive mycoses

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE Physical interactions between cells influence many important aspects of embryo development. This proposal uses the nematode embryo as a model system to determine how cellular interactions regulate the shape, organization, and function of cells, tissues, and organs. Our findings will provide insights into how cell interactions contribute to human embryo development, and how defective cellular interactions can contribute to birth defects and diseases such as cancer.

PI_NAMEs: NANCE, JEREMY  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Address;Apical;Biological Models;Blood capillaries;Caenorhabditis elegans;Cannibalism;Cell Communication;Cell Physiology;Cells;Cellular biology;Complex;Congenital Abnormality;Cytoplasm;Cytoplasmic Tail;Development;Disease;E-Cadherin;Embryo;Embryonic Development;Ensure;Epithelial Attachment;Event;Foundations;genetic analysis;Germ Cells;Germ Lines;Goals;Health;Human Development;human disease;human embryonic development;Image;in vivo Model;insight;Intestines;Invaded;Learning;Link;Lobe;Malignant Neoplasms;Membrane;Mitochondria;Molecular;Nematoda;Organ;PAC1 phosphatase;polarized cell;programs;Proteins;recruit;Research;rho GTPase-activating protein;Role;Shapes;Signal Pathway;Signal Transduction;Site;Specific qualifier value;stem cells;Structure of primordial sex cell;System;Testing;Tissues;Tube;Vesicle

PROJECT_TITLE: The role of cell interactions in shaping development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PITTSBURGH

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Transfer learning to improve the re-usability of computable biomedical knowledge Narrative Re-using computable biomedical knowledge in the form of a mathematical model in a new setting is challenging because the new setting may not have data needed as inputs to the model. This project will develop and evaluate transfer learning algorithms, which are computer programs that adapt a model to a new setting by removing and adding local variables to it. The developed methods for re-using models are expected to benefit the public’s health by: (1) improving case detection during epidemics by enabling re-use of automatic case detectors developed in the earliest affected regions with other regions, and, more generally, (2) increasing the impact of NIH’s investment in machine learning by enabling machine-learned models to be used in more institutions and locations.

PI_NAMEs: YE, YE  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Affect;Algorithms;Applications Grants;Area;Artificial Intelligence;Bayesian Method;Bayesian Modeling;Bayesian Network;Big Data;career;career development;Clinical;Communicable Diseases;Communication;Complement;computable knowledge;computer program;Computerized Medical Record;Computers;convolutional neural network;Data;deep learning;deep neural network;Detection;detector;Development;Diagnosis;Disease;Epidemic;Epidemiology;experience;Future;Goals;Grant;Health;health care settings;Healthcare Systems;Heterogeneity;improved;Influenza;insight;Institution;Investigation;Investments;Knowledge;large datasets;Lead;Learning;learning algorithm;Location;Machine Learning;machine learning model;mathematical model;Medical center;Medicine;Mentors;Methods;Modeling;multidisciplinary;Natural Language Processing;neural network;Parainfluenza;Patients;Performance;Play;Preventive Medicine;Process;Public Health;Public Health Informatics;Research;Research Personnel;Respiratory Disease;Role;Semantics;skills;Societies;Source;statistics;Testing;Time;Training;training data;transfer learning;Twin Multiple Birth;Unified Medical Language System;United States National Institutes of Health;Universities;Update;Utah;Work;Writing

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Project Narrative: Mutation of genes involved in chromatin regulation frequently underlie cancer. We have identified and validated two genes that when deleted, cause cell death specifically in childhood cancers mutant for the SWI/SNF chromatin remodeler subunit SMARCB1. The proposed studies are designed to determine the normal function of these two genes and to define the mechanisms by which they kill these childhood cancers, with the ultimate goal of yielding new therapeutic approaches.

PI_NAMEs: ROBERTS, CHARLES  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Acetylation;Adult;antagonist;Automobile Driving;Binding;Biology;Bypass;cancer cell;Cancer cell line;cancer genome;cancer genomics;cancer predisposition;Cell Death;Cell Proliferation;Cell Survival;Cells;Childhood;Childhood Precursor T Lymphoblastic Leukemia;Chromatin;Chromatin Remodeling Factor;Clinical Trials;Coffin-Siris Syndrome;Complex;CRISPR/Cas technology;Cullin Proteins;Data;Defect;Dependence;design;Diploidy;Disease;DNA Polymerase II;Drosophila snf protein;early childhood;effective therapy;Enhancers;EZH2 gene;Frequencies;Gene Mutation;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Genome;Genome Stability;genome wide screen;Goals;Growth;Hereditary Malignant Neoplasm;High Prevalence;Histone H3;Histones;in vivo evaluation;inhibitor;insight;Lead;Link;Lysine;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Modeling;mutant;Mutate;Mutation;Nature;neoplastic cell;Neurodevelopmental Disorder;new therapeutic target;Normal Cell;novel;novel therapeutic intervention;Pediatric Neoplasm;promoter;Proteins;receptor;recruit;Recurrence;Regulation;Residual state;Rhabdoid Tumor;RNA;Role;Sarcoma;SMARCB1 gene;Specific qualifier value;SWI/SNF Family Complex;Syndrome;Testing;Therapeutic;therapeutic target;tool;Toxic effect;Transcriptional Regulation;Translating;translational therapeutics;Tumor Cell Line;tumor growth;Tumor Suppressor Proteins;tumorigenesis;ubiquitin-protein ligase;Work;Xenograft procedure;Zinc Fingers

PROJECT_TITLE: Cancer-based discovery of novel mechanisms of chromatin control

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

PHR: No changes The proposed project investigates fluorescence image-guided surgery to allow precise identification of necrotic tissue both preoperatively and intraoperatively in burn patients. Furthermore, it uses a multi-model approach to elucidate the localization of indocyanine green inflammation and necrosis to determine how this novel use of a well-known fluorescence marker can be optimized to aid in surgical decision making. This proposal will provide the necessary data to support the design of a larger clinical trial to study the feasibility and efficacy of this technology to improve the precision of necrosis detection and removal and improve wound healing outcomes.

PI_NAMEs: GIBSON, ANGELA L F (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Adopted;Angiography;Animal Model;Area;biomarker identification;Blood capillaries;Burn injury;burn model;Caring;Cause of Death;Cell Culture Techniques;Cell Death;Cellular Infiltrate;chronic wound;Cicatrix;Clinical;Clinical Data;clinical decision-making;Clinical Trials;Darkness;Data;Decision Making;design;Detection;detection method;diagnostic accuracy;Disease;Dose;Early Intervention;efficacy evaluation;Evaluation;Excision;Excretory function;experience;Family suidae;Feasibility Studies;Fluorescence;fluorescence imaging;fluorescence-guided surgery;Goals;Half-Life;healing;heat injury;Hemorrhage;Histologic;Human;Image;Image-Guided Surgery;Imaging Device;Imaging technology;improved;improved outcome;In Vitro;in vivo;in vivo imaging;Indocyanine Green;Inferior;Inflammation;Inflammatory;injured;Injury;insight;Knowledge;Life;Light;Lighting;Malignant Neoplasms;Measures;Methods;Microscopic;Modeling;mouse model;Mus;Necrosis;necrotic tissue;novel;Operative Surgical Procedures;Outcome;Pain;Patient Admission;Patients;Perfusion;Perioperative;pre-clinical;preservation;prevent;Process;Quality of life;randomized, clinical trials;Regenerative capacity;Science;Scientist;Sensitivity and Specificity;Signal Transduction;skin xenograft;Soft Tissue Infections;standard of care;Surgeon;Surrogate Markers;systemic inflammatory response;Techniques;Technology;Testing;tissue injury;Tissue Viability;Tissues;Tourniquets;trial comparing;tumor;Unnecessary Surgery;Visual;Visualization;wound;wound healing

PROJECT_TITLE: Fluorescence-based detection of inflammation and necrosis to inform surgical decision-making and enhance outcomes

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: EAST LANSING

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Human papillomaviruses (HPVs) are causally linked to 5% of all human cancers, including ~25% of HNSCCs, resulting in half a million deaths every year. An epidemic-level increase in HPV+ HNSCC requires urgent needs to develop new tools to treat HNSCC patients. The goal of this proposal is to investigate the mechanism by which the chemokine CXCL14 suppresses HNSCC growth, and test if CXCL14 serves as a useful immunomodulatory target for novel immunotherapies to treat HPV+ HNSCC.

PI_NAMEs: PYEON, DOHUN  (contact);SPANOS, WILLIAM CHARLES

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Adenoviruses;anti-tumor immune response;Antigen Presentation;antigen-specific T cells;Antigens;Automobile Driving;Basic Science;Binding Proteins;cancer infiltrating T cells;CD8-Positive T-Lymphocytes;CD8B1 gene;cell killing;cell motility;Cell surface;Cells;Cessation of life;chemokine;Combined Modality Therapy;Complex;CXCL14 gene;Data;Disease Progression;DNA;Epidemic;G-Protein-Coupled Receptors;Goals;Growth;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;HPV negative;HPV positive;Human;Human Papillomavirus;I-antigen;IL8RB gene;Immune;Immune checkpoint inhibitor;Immunity;Immunocompetent;immunodeficiency;Immunology;immunoregulation;Immunotherapeutic agent;Immunotherapy;in vivo evaluation;inhibitor;Injections;Knock-out;Lentivirus;Link;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;Messenger RNA;Methylation;Modeling;mouse model;Mus;Natural Killer Cells;neoplastic cell;Normal tissue morphology;novel;Oncology;oral HPV-positive head and neck cancers;Patients;Peptides;Positioning Attribute;Proteins;Rag1 Mouse;receptor;recruit;refractory cancer;screening;Skin;System;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;Technology;Testing;Tissues;tool;trafficking;transcriptome;Translational Research;tumor;tumor growth;Tumor Immunity;tumor progression;Tumor Suppression;Tumor Suppressor Proteins;tumor-immune system interactions;Up-Regulation;Viral;virology

PROJECT_TITLE: Chemokine-mediated antigen-specific T cell responses and immunotherapies to treat head and neck cancer

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE The goal of the proposed research is to interrogate the role of miR-181a in the emergence of immune tolerance and tumor development through the regulation of Stimulator of Interferon Genes (STING). Defective STING signaling is one of the primary means by which a high grade serous cancer (HGSC) create an immunosuppressive microenvironment thus its re-activation can potentially induce tumor interferon signaling, decrease tumor volume, as well as induce anti-tumor innate/adaptive immune response. We propose to test the co-operativity between miR-181a loss and STING agonists to restore innate immune signaling in HGSC and induce tumor cell death and ultimately have a significant impact on public health.

PI_NAMEs: DIFEO, ANALISA VIRGINIA (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acceleration;Activated Lymphocyte;adaptive immune response;adaptive immunity;Agonist;anti-PD-1;anti-PD-L1;anti-PD1 therapy;anti-tumor immune response;Apoptosis;Automobile Driving;beta catenin;Biological;cancer diagnosis;Cancer Model;cancer therapy;Carcinoma;Cell Death;Cell Death Induction;Cells;Chemoresistance;Clinical;clinical biomarkers;clinical development;clinically relevant;Coculture Techniques;cytokine;Cytoplasm;cytotoxic;Death Rate;Development;Disease Progression;DNA;DNA Damage;Drug resistance;epithelial to mesenchymal transition;experimental study;Gene Activation;Gene Expression;gene induction;Genes;Genetic;Genomic Instability;Genomics;Goals;Growth;immune activation;immune cell infiltrate;immune resistance;Immune response;Immune signaling;Immune Tolerance;Immunocompetent;Immunologic Surveillance;Immunosuppression;Immunotherapy;improved;in vivo;inhibitor;Interferons;Link;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Mediating;monocyte;mouse model;Mus;Mutate;Natural Immunity;Neoplasm Metastasis;neoplastic cell;Neoplastic Cell Transformation;novel;Organoids;Outcome;overexpression;Pathway interactions;Patients;peripheral blood;Play;pre-clinical;Pre-Clinical Model;Predisposition;prevent;prognostic value;Proliferating;Property;Public Health;RB1 gene;recruit;Recurrence;Recurrent tumor;Regulation;Repression;Research;response;Role;Serous;Signal Pathway;Signal Transduction;stem-like cell;stemness;Stimulator of Interferon Genes;targeted agent;Testing;Therapeutic;therapeutic target;three-dimensional modeling;Time;Transforming Growth Factor beta;Transgenic Mice;Treatment Efficacy;tumor;Tumor Immunity;tumor initiation;Tumor Promotion;Tumor Suppressor Genes;Tumor Volume;tumor-immune system interactions;Tumor-infiltrating immune cells;Viral;women's diagnosis;Work

PROJECT_TITLE: Examining the role of the miR-181a:Wnt/B-catenin axis in ovarian cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: FARGO

ORG_NAME: SANFORD RESEARCH NORTH

ORG_STATE: ND

PHR: Overall Center for Bio-behavioral Mechanisms of Eating Behavior NARRATIVE Eating disorders represent one of the most serious and lethal psychiatric disorders. Also, rates of obesity are increasing dramatically across the United States with highly significant medical, social, and economic implications. The purpose of the proposed COBRE is to establish a Center for Bio-behavioral Mechanisms of Eating Behavior (CBM-EB) at the Sanford Center for Bio-behavioral Research that will support comprehensive biomedical studies of eating disorders and eating behavior, while mentoring early career investigators in these areas. The five proposed projects focus on bio-behavioral factors which increase risk, or operate to maintain the disorder.

PI_NAMEs: WONDERLICH, STEPHEN ARTHUR (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Affect;Area;Behavior assessment;Behavioral;biobehavior;Biological Assay;career;Center for Translational Science Activities;Centers of Research Excellence;Clinical;Clinical Research;clinically relevant;cognitive testing;Collaborations;Data Analyses;Data Collection;design;Development;Disease;Eating;Eating Behavior;Eating Disorders;economic implication;FarGo;Functional Magnetic Resonance Imaging;Funding;human subject;Human Subject Research;innovation;Intervention;Magnetic Resonance Imaging;Maintenance;Medical;medical schools;Mental disorders;Mentors;Mentorship;Methodology;Methods;Modality;National Institute of Mental Health;Neurobiology;neuroimaging;North Dakota;Obesity;Process;Psychopathology;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;Risk;Series;Services;social implication;statistics;Strategic Planning;Study Subject;Testing;Training;training opportunity;Training Programs;United States;Universities

PROJECT_TITLE: Center for Biobehavioral Mechanisms of Eating Behavior


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Eating Disorders;Mental Health

PROJECT_TERMS: Address;Advisory Committees;Area;biobehavior;career;Centers of Research Excellence;Clinical Research;clinical training;clinically relevant;Collaborations;Consultations;Development;Eating Behavior;Eating Disorders;Education;Elements;Ensure;Evaluation;experience;Fostering;Functional Magnetic Resonance Imaging;Funding;Goals;Grant;Health Services Research;human subject;Human Subject Research;imaging study;Infrastructure;innovation;Laboratories;Magnetic Resonance Imaging;Maintenance;Measurement;medical schools;meetings;Mental disorders;Mentors;Mentorship;neuroimaging;North Dakota;Obesity;Pilot Projects;Process;programs;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;Scientist;Services;Site;statistical service;statistics;Structure;Testing;Training;training opportunity;Training Programs;Translational Research;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative Recent research has made dramatic strides by revealing how the brain organizes and ‘navigates’ continuous, non-spatial task dimensions as a cognitive map in typical and atypical individuals. A cognitive map of a task confers powerful advantages for flexible behavior and generalization, which are compromised in several psychiatric conditions. However, how cognitive maps of discrete and abstract tasks commonplace in the real world contribute to such flexibile behavior remains largely unknown. The present project aims to develop a new neural model of how discrete, abstract tasks are represented and used for flexible behavior during decision-making.

PI_NAMEs: BOORMAN, ERIE D (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Acceleration;Auditory;Behavior;Behavioral;Biological Markers;Brain;Clinical;Code;Cognition;Cognitive;Collaborations;Computer Models;Data;Decision Making;Dimensions;Diné Nation;Disease;Eating;Environment;Event;experience;flexibility;Functional disorder;Functional Magnetic Resonance Imaging;Genealogical Tree;Goals;Hippocampus;Human;Hybrids;Individual;insight;Investigation;Knowledge;learned behavior;Learning;Length;Literature;Maps;Marriage;Measures;Memory;Mental disorders;Methods;Modeling;Mood Disorders;neural;neural model;novel;Obsessive-Compulsive Disorder;Outcome;Pattern;Persons;Positioning Attribute;Process;Psyche structure;Recording of previous events;Research;Response to stimulus physiology;Rewards;Schizophrenia;sensory feedback;social;Social Network;social space;sound frequency;Stimulus;Structure;Substance abuse problem;System;Task Performances;Testing;Time;two-dimensional;vestibular system;Visual;way finding

PROJECT_TITLE: Cognitive maps for goal-directed decision making

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Eating Disorders;Mental Health

PI_NAMEs: ENGEL, SCOTT G (contact)

PROJECT_TERMS: Area;Behavioral;Behavioral Mechanisms;biobehavior;Biological;Centers of Research Excellence;Clinical;Cognition;Collection;Consultations;design;Development;Diagnostic;Eating Behavior;Eating Disorders;Educational process of instructing;experience;Faculty;Funding;Future;Generations;Geographic Locations;Goals;Human Resources;improved;Individual;innovation;Laboratories;Maintenance;Measures;medical schools;Mentors;Methodology;Methods;Modality;multimodality;neural correlate;Neurobiology;neuroimaging;North Dakota;novel;Obesity;Pharmacologic Substance;Psychology;Psychopathology;Research;Research Personnel;Resources;Running;Science;Scientific Advances and Accomplishments;Services;student mentoring;Students;System;Technology;Training;training opportunity;training project;Universities;Update

PROJECT_TITLE: Research Assessment Services Core


NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: The proposed research is relevant to public health because we are generating new methods aimed at increasing diagnostic accuracy, reducing inter-observer variability that will ultimately enable efficient patient care for personalized breast cancer therapies. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to the application of novel strategies that may improve human health.

PI_NAMEs: GURCAN, METIN NAFI (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Age;Attention;Biological Assay;Biological Markers;Biopsy;Breast Cancer Patient;Breast Cancer Risk Factor;Breast Cancer therapy;breast imaging;Cancer Prognosis;Categories;Cell Nucleus;Cells;chemotherapy;Classification;Clinical;Clinical Research;Clinical Trials;cohort;Consumption;cost;cost effective;Data;design;detection method;Developing Countries;Diagnosis;Diagnostic;diagnostic accuracy;Disease;Duct (organ) structure;Effectiveness;Ensure;Epithelium;erbB-2 Receptor;ERBB2 gene;Estrogen receptor positive;Estrogen Receptors;Estrogens;Gene Expression;Genes;Health;Hematoxylin and Eosin Staining Method;high risk;Histologic;Histology;Histopathology;hormone receptor-positive;Human;Image;Image Analysis;imaging biomarker;improved;Internet;Interobserver Variability;large datasets;Learning;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Methods;Mission;Modeling;mortality;Nature;novel strategies;oncotype;optimal treatments;Outcome;overexpression;patient stratification;Patients;Performance;personalized care;Play;Population;Premature Menopause;prevent;Progesterone;progesterone receptor positive;Progesterone Receptors;Prognosis;Public Health;receptor;Recurrence;Recurrence Score;Regional Anatomy;Research;Resource-limited setting;Resources;Reverse Transcriptase Polymerase Chain Reaction;Risk;risk stratification;rural area;side effect;Slide;Stains;Stratification;Time;Tissues;tool;Training;tumor;Tumor stage;Tumor Tissue;United States;United States National Institutes of Health;Validation;web-based tool;whole slide imaging;Woman

PROJECT_TITLE: Efficient and cost-effective breast cancer risk stratification using whole slide histopathology images


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Eating Disorders;Mental Health

PI_NAMEs: CROSBY, ROSS D (contact)

PROJECT_TERMS: Area;biobehavior;Biometry;Centers of Research Excellence;Clinical Research;cognitive testing;Collaborations;Consultations;Data;Data Analytics;Data Collection;data management;Data Storage and Retrieval;Development;Eating Behavior;Eating Disorders;Ecological momentary assessment;Education;Educational Activities;Educational workshop;Ethics;experience;Faculty;FarGo;Grant;handheld mobile device;human subject;Individual;Infrastructure;innovation;Institution;interest;Interview;Laboratories;Machine Learning;Maintenance;medical schools;Mentors;Methodology;Methods;Modality;Monitor;multimodal data;neuroimaging;North Dakota;Patient Self-Report;Pharmacologic Substance;Phase;power analysis;Preparation;Process;Protocols documentation;Psychology;Psychophysiology;Publications;Questionnaires;Research;research and development;Research Design;Research Personnel;Sample Size;Science;Services;skills;Statistical Data Interpretation;statistics;Structure;Testing;tool;Training;training opportunity;training project;Translational Research;Universities;Work;Writing

PROJECT_TITLE: Biomedical Statistics Core


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Prevention;Telehealth

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: 3c. Project Narrative Dental disease is caused primarily by poor oral hygiene behaviors. Our research will contribute to the development of technology-assisted behavioral interventions that use electronic toothbrushes and mobile phone apps to provide individuals with personalized feedback on their brushing behaviors and eventually, improve oral health and decrease dental disease.

PI_NAMEs: SHETTY, VIVEK  (contact)

PROGRAM_OFFICER_NAME: MATTIA, JILL

PROJECT_TERMS: adaptive intervention;Address;Adherence;Adult;arm;Behavior;behavior change;Behavior Therapy;Behavioral Sciences;Bioethics;blind;Calibration;Cellular Phone;Chronic Disease;Clinic;Clinical Trials Cooperative Group;cohort;Communication;Computer Models;Data;Dental;Dental caries;Dental Clinics;Dental Hygiene;Dentistry;Dentists;design;digital;digital delivery;digital health;digital technology;Drops;effectiveness evaluation;Electronics;Elements;Eligibility Determination;Ensure;evidence base;Failure;Feedback;Fostering;Gingival Indexes;handheld mobile device;Health behavior;health literacy;health organization;Healthcare;High Prevalence;high risk;Home;improved;indexing;Individual;industry partner;Infrastructure;innovation;Instruction;Intervention;Knowledge;Link;Machine Learning;Maintenance;Methodology;Oral;oral communication;Oral health;patient engagement;Patient Recruitments;Patients;Penetration;Periodontal Diseases;Phase;Population;population health;Prevention;primary outcome;Procter and Gamble;Proxy;Randomized;randomized trial;remote monitoring;Research;Resources;response;Risk;Running;safety net;Science;secondary outcome;Self Care;smartphone application;System;Target Populations;Technology;technology development;Testing;Theory of Change;Time;Tooth Diseases;Toothbrushing;Training;treatment arm;United States;usability;Visit;Vulnerable Populations

PROJECT_TITLE: Personalized Digital Behavior Change Interventions to Promote Oral Health


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Economic choice, a behavior specifically disrupted in disorders such as frontotemporal dementia and major depression, relies on the computation and comparison of subjective values. This project will examine the role of orbitofrontal cortex, the amygdala, inferotemporal cortex and gustatory cortex in these mental operations. 1

PI_NAMEs: PADOA-SCHIOPPA, CAMILLO  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Address;Affect;Amygdaloid structure;Anatomy;Animals;Area;Association Learning;Attention;Behavior;Behavior Control;Brain;Brain region;Cells;Choice Behavior;Clinical Data;Computational Technique;Decision Making;Dimensions;Disease;Drug Addiction;Economics;Electric Stimulation;Emotions;experimental study;Foundations;Frontotemporal Dementia;Functional Imaging;Goals;Individual;inferotemporal cortex;Intuition;Juice;Lesion;Light;Link;Major Depressive Disorder;Mental disorders;mental function;Modality;Monkeys;Nervous System Disorder;neural;neural circuit;Neurons;neurophysiology;nonhuman primate;operation;Outcome;Output;Population;Process;Productivity;Psyche structure;Records;Role;Sensory;Signal Transduction;success;Testing;Visual;visual stimulus;Work

PROJECT_TITLE: Neuronal Mechanisms of Good-Based Economic Decisions

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Eating Disorders;Mental Health

PI_NAMEs: BLACK, LORA  (contact)

PROJECT_TERMS: Address;Area;Attention;Awareness;biobehavior;Centers of Research Excellence;Clinical Research;Clinical Trials Data Monitoring Committees;Collaborations;Consultations;Country;Data;Data Set;design;Development;didactic education;Disadvantaged;Documentation;Eating Behavior;Eating Disorders;Education;Education Projects;Ethnic Origin;experience;FarGo;Gender;Goals;Grant;Human Activities;Human Resources;human subject;Human Subject Research;Individual;innovation;Institutional Review Boards;International;Knowledge;Logistics;Maintenance;medical schools;meetings;Mentors;Methods;Monitor;North Carolina;North Dakota;Participant;Pharmacologic Substance;Positioning Attribute;protocol development;Psychology;quality assurance;Race;recruit;Regulation;Research;Research Project Grants;Research Support;Safety;Sampling;Science;Site;Study models;synergism;Training;Training Programs;United States;Universities;Work

PROJECT_TITLE: Human Subject Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Precision Medicine

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Crohn’s disease (CD) is a chronic, progressive disease that can cause irreversible bowel damage with complications including strictures, fistulae and bowel resections. As the armamentarium of therapeutic agents for CD continues to expand, there is an increasing need for precision medicine approaches in treatment selection. In this grant, we aim to expand and improve the performance of a set of blood proteins that can predict anti-tumor necrosis factor alpha (anti-TNF) treatment response and then to explore blood biomarkers of response to a newer drug class used to treat CD, anti-interleukin 12/23 (anti-IL12/23).

PI_NAMEs: UNGARO, RYAN  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Area;Award;Biological;Biological Assay;Biological Markers;Biological Products;biomarker panel;biomarker validation;Biopsy;Blood;Blood Proteins;blood-based biomarker;cell type;chemokine;Child;Chronic;Clinical;clinical application;clinical practice;cohort;Crohn's disease;cytokine;Data;Dendritic Cells;Diagnosis;Disease;Disease Progression;Endothelial Cells;Excision;Failure;Fibroblasts;Fistula;Foundations;Future;Gastrointestinal tract structure;Gene Expression;Grant;Ileal Diseases;Immunogenetics;Immunoglobulin G;improved;indexing;Individual;Inflammation;Inflammatory;Interleukin-12;Intestinal Fistula;Intestines;large bowel Crohn's disease;Macrophage;Medical;microbial;Mononuclear;new therapeutic target;novel;novel drug class;Oceans;Operative Surgical Procedures;Pathway interactions;Patient risk;Patients;Performance;peripheral blood;Phagocytes;Pharmaceutical Preparations;Pilot Projects;Plasma Cells;potential biomarker;precision medicine;Progressive Disease;Prospective cohort;Proteins;Proteomics;Refractory;Registries;Research;Resistance;response;response biomarker;risk stratification;Sampling;Selection for Treatments;Serum;single cell sequencing;Specificity;Stromal Cells;T-Cell Activation;Therapeutic Agents;Time;Tissues;TNF gene;transcriptome sequencing;treatment response;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Blood Protein Markers of Biologic Treatment Response in Crohn's Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


PHR: PROJECT NARRATIVE People with human immunodeficiency virus (HIV) are at increased risk of age-related disease and complications such as frailty. The proposed research aims to determine 1) the associations of free testosterone and sex hormone binging globulin (SHBG) concentrations with incident frailty, 2) the association of diurnal variation in free testosterone with HIV serostatus and its association with systemic inflammation, 3) the association of novel SHBG glycans with frailty among men with HIV. This work will inform efforts to find new therapeutic targets for frailty via the improvement of alterations in the hypothalamic-pituitary-gonadal axis in men with HIV.

PI_NAMEs: PENA DIAS, JENNY  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Age;age acceleration;age related;Age related comorbidities;age-related disease;Aging;aging process;aging related;Anabolic Agents;antiretroviral therapy;Apnea;Award;Biological Markers;Biostatistical Methods;Bisexual;Blood specimen;bone strength;Capillary Electrophoresis;career;Carrier Proteins;Characteristics;Chronic;Clinical;Communicable Diseases;Data;design;Disease;Diurnal Rhythm;Enrollment;Epidemic;Epidemiology;epidemiology study;experience;falls;frailty;Free Association;Functional disorder;General Population;Globulins;Glycoproteins;glycosylation;Goals;Gonadal Steroid Hormones;high risk;HIV;HIV Seronegativity;HIV Seropositivity;HIV-1;Homosexuals;Hormones;Hospitalization;Hypogonadism;Hypothalamic dysfunction;hypothalamic pituitary gonadal axis;Hypothalamic structure;Immune;Immunoglobulin G;Impairment;improved;Infection;Inflammation;Inflammatory;inflammatory marker;inflammatory milieu;inflammatory modulation;Inflammatory Response;insight;Interleukin-6;Intervention;Investigation;Knowledge;Knowledge acquisition;Laboratories;Lectin;Longevity;Longitudinal Studies;Measurement;Measures;Mediating;men;Mentors;Methods;Monosaccharides;mortality;new therapeutic target;novel;novel strategies;older adult;Outcome;Pathogenesis;patient population;Pattern;Performance;Persons;Physical Function;Pituitary Gland;Plasma;Plasma Proteins;Play;Polysaccharides;premature;Prevalence;prevent;Prospective Studies;Protein Glycosylation;Proteins;Recording of previous events;Reporting;Research;Research Personnel;Risk;Role;Serum;Sex Hormone-Binding Globulin;sialylation;Sleep;Statistical Methods;Systemic infection;systemic inflammatory response;Techniques;Testosterone;The Multicenter AIDS Cohort Study;Time;TNFRSF1A gene;Visit;Work

PROJECT_TITLE: Alteration in the hypothalamic-pituitary-gonadal axis and frailty in aging men with HIV

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Data Science;Infertility;Maternal Health;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE Drug exposure in pregnancy is common although data available to pregnant patients and their providers on the risks and benefits of drug use in pregnancy are sparse. Reducing adverse pregnancy and infant outcomes requires new approaches to address the insufficient pace of new information on safe use of medicines in pregnancy. In this study we will combine a) innovative data-mining techniques that can evaluate multiple drugs and outcomes simultaneously with b) formal assessments of prioritized safety signals obtained from data mining in real world populations.

PI_NAMEs: MARO, JUDITH  (contact);WINTERSTEIN, ALMUT G

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Acceleration;Address;adverse birth outcomes;adverse pregnancy outcome;Algorithms;Animals;Attention;Benefits and Risks;Big Data;Birth Certificates;black patient;Chemicals;Clinical;Clinical Trials;cohort;collaboratory;Data;Data Engineering;data mining;Data Set;data structure;Death Certificates;design;Development;Drug Evaluation;Drug Exposure;drug use in pregnancy;Effectiveness;eHealth;Eligibility Determination;Enrollment;Evaluation;experience;Exposure to;Federal Government;Fetal Death;Generations;Goals;Government Agencies;Healthcare;healthy pregnancy;human data;Individual;Infant;infant outcome;Information Systems;Infrastructure;innovation;Label;Link;Live Birth;malformation;Measurement;Measures;Medicaid;medication safety;Medicine;Methodology;Methods;Mothers;Neonatal Intensive Care;novel;novel strategies;Observational Study;offspring;Outcome;Outcome Assessment;Pathway interactions;Patients;Perinatal;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacologic;Pneumonia;Population;Population Surveillance;Pregnancy;Pregnancy loss;pregnant;prenatal;prenatal exposure;Privatization;programs;Provider;Public Health;Quality Control;Records;Registries;Research;Residual state;Risk;Safety;safety study;Scanning;Seizures;Sentinel;Signal Transduction;Site;Small for Gestational Age Infant;Source;Specialist;Spontaneous abortion;stillbirth;System;Techniques;Teratogens;Therapeutic;Time;translational framework;Triage;United States National Institutes of Health;vaccine safety;Vulnerable Populations;Work

PROJECT_TITLE: Big data apprOaches fOr Safe Therapeutics in Healthy Pregnancies (BOOST-HP)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine

PHR: PROJECT NARRATIVE This proposal aims to refine the development of biofabrication approaches to create personalized scaffolds for periodontal regeneration. Successful completion of this project is central to translating personalized therapies to treat tissue destruction caused by gum disease and thus saving millions of teeth from extraction.

PI_NAMEs: BOTTINO, MARCO C (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Affect;alveolar bone;American;Animal Model;antimicrobial;Architecture;Bacteria;Biocompatible Materials;biofabrication;Biological Process;bone;bone engineering;Bone Growth;bone loss;bone scaffold;calcium phosphate coating;canine model;Ceramics;Chemicals;Chronic;Clinical;clinical efficacy;clinically relevant;Data;Defect;Dental Cementum;Dentition;design;Development;Disease;efficacy evaluation;Engineering;fabrication;Fiber;Genes;Goals;Growth and Development function;human old age (65+);improved;In Vitro;in vivo;in vivo Model;Inflammatory;Ink;innovation;inorganic phosphate;Lasers;Left;Magnesium;manufacture;Mechanics;Medicine;melting;Morphology;Mouth Diseases;Nanostructures;Natural regeneration;Nature;novel;Patients;Periodontal Ligament;Periodontic specialty;Periodontitis;personalized medicine;personalized strategies;Physiological;Polymers;Printing;regenerative therapy;Role;scaffold;Silver;Structure;Surface;Technology;Therapeutic;tissue regeneration;Tissues;tool;Tooth Extraction;Tooth Loss;Tracheobronchomalacia;Translating;Translations

PROJECT_TITLE: Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication Approach


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Nutrition

PI_NAMEs: SCHAEFER, LAUREN MARIE (contact)

PROJECT_TERMS: Affect;Behavioral;Belief;Binge Eating;biobehavior;Bulimia;Characteristics;cognitive task;comorbidity;Consumption;Development;Diagnostic;Disease;Disease remission;Eating;Eating Behavior;Ecological momentary assessment;Emotions;Environment;Etiology;Exhibits;Expectancy;expectation;experience;Feeling;follow-up;Food;food consumption;Frequencies;Future;Goals;high reward;Impairment;improved;Individual;Intervention;Interview;Lead;Learning;longitudinal design;loss of control over eating;Maintenance;Measures;Mediating;Mediation;Medical;Modeling;multimodality;negative affect;Obesity;Outcome;Patient Self-Report;preference;Prevention;Process;prospective;Psychological reinforcement;psychosocial;Questionnaires;Recording of previous events;reduced food intake;Reporting;Research;reward processing;Rewards;Risk;Risk Factors;Severities;Shapes;Symptoms;Testing;Theoretical model;theories;Time;Weight Gain;Work

PROJECT_TITLE: A Longitudinal Examination of Reward, Eating Expectancies, and Inhibitory Control in the Progression of Loss of Control Eating


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Neurosciences;Precision Medicine;Racial and Ethnic Minority Health Research;Sleep Research;Stroke

PHR: Project Narrative Leveraging the infrastructure of the parent BASIC project and its ancillary study, we propose the largest study of polysomnography among stroke patients. This population-based study will quantify the physiological underpinnings of sleep apnea in post-stroke patients and stroke-free participants for the first time. This study will provide opportunities for personalized medicine for post-stroke sleep apnea, as an understanding of the underlying pathophysiology has direct implications for treatment selection and success.

PI_NAMEs: BROWN, DEVIN L (contact);LISABETH, LYNDA D

PROGRAM_OFFICER_NAME: HONG, YULING

PROJECT_TERMS: Adult;American;Anatomy;Ancillary Study;Arousal;brain pathway;Case Study;Categories;Clinical;Clinical Data;comparison group;Compensation;Complement;Data;Data Collection;Deformity;Development;disability;Disease;disparity reduction;ethnic difference;Ethnic Origin;Face;Feedback;follow-up;Functional disorder;General Population;health disparity;high body mass index;High Prevalence;improved;improved outcome;indexing;Individual;Infrastructure;Interruption;Ischemic Stroke;Measures;Methods;Mexican Americans;Modeling;Not Hispanic or Latino;novel;Obstructive Sleep Apnea;Outcome;outcome disparities;Parents;Participant;Patients;personalized care;personalized medicine;Pharyngeal structure;pharynx muscle;Phenotype;phenotypic data;Physiological;Polysomnography;population based;Population Study;portability;post stroke;predictive modeling;Predisposition;Prevention;Prospective Studies;Reflex action;Resistance profile;Resolution;Selection for Treatments;Severities;Sleep;Sleep Apnea Syndromes;Stroke;stroke outcome;stroke patient;Study Subject;success;Testing;Time;treatment response

PROJECT_TITLE: Towards personalized medicine: pathophysiologic contributions to post-stroke sleep apnea

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Genetics

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE One of the fundamental and highly regulated events in the generation of functional mRNAs is 3’-processing and transcription termination. Through genetic and biochemical studies, the proposal investigates the molecular mechanisms by which small metabolites (inositol pyrophosphates) influence 3’-processing/termination. Defects in this process are linked to human diseases, including cancer.

PI_NAMEs: SCHWER, BEATE  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Acid Phosphatase;activating transcription factor;Affect;Agonist;analytical method;Apoptosis;Binding;Binding Sites;Biochemical;cell growth regulation;cell motility;Cell Physiology;Cell surface;Cells;ChIP-seq;Code;Complex;Defect;derepression;Diabetes Mellitus;Diphosphates;Enzymes;Event;Fission Yeast;Funding;fungus;gain of function mutation;Gene Expression;Generations;Genes;Genetic;genetic analysis;genetic manipulation;genetic predictors;Genetic Screening;genetic strain;Genetic Transcription;Glycerophosphates;Growth;hearing impairment;Homeostasis;Human;human disease;Human Pathology;in vivo;inorganic phosphate;Inorganic Phosphate Transporter;Inositol;Lead;Link;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;Messenger RNA;Modeling;Molecular;mRNA Cleavage and Polyadenylation Factors;mRNA Expression;Mutation;novel;Obesity;Pathway interactions;Plants;pleiotropism;Polymerase;Post-Translational Protein Processing;Process;promoter;Protein Isoforms;protein protein interaction;Proteins;pyrophosphatase;Regulon;Repression;response;RNA;RNA Binding;RNA Polymerase II;Role;Schizosaccharomyces pombe Proteins;Signal Transduction;Signaling Molecule;Site;Specific qualifier value;Starvation;System;Taxon;Telomere Maintenance;termination factor;Testing;trafficking;transcription termination;ubiquitin-protein ligase;Untranslated RNA

PROJECT_TITLE: Inositol pyrophosphate dynamics affect RNA 3'-processing/transcription termination

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Eating Disorders;Mental Health;Nutrition;Obesity;Prevention;Sleep Research

PI_NAMEs: IRISH, LEAH A (contact)

PROJECT_TERMS: Achievement;actigraphy;adult obesity;Affect;American;Attenuated;Behavioral;Binge Eating;biobehavior;Body Composition;Body fat;Body Weight;Body Weight Changes;Body Weight decreased;Buffers;Calories;Centers of Research Excellence;Chronic Disease;Clinical;Cognitive;cognitive control;cognitive function;cognitive process;cognitive task;Consumption;Cost of Illness;Cross-Sectional Studies;Decision Making;design;Development;diaries;dietary;disability;Eating;Eating Behavior;Eating Disorders;executive function;experience;Fatty acid glycerol esters;flexibility;Food;fruits and vegetables;Health Resources;high body mass index;Impaired cognition;Impairment;improved;Individual;Individual Differences;insight;Interview;Knowledge;Link;Literature;Maintenance;Measures;Mediating;Modeling;mortality;mortality risk;Neurocognitive;novel;Obesity;obesity prevention;obesity treatment;Overweight;overweight adults;Participant;Patient Self-Report;prevent;Process;prospective;Public Health;Quality of life;Reporting;Research;Resource Allocation;Resources;Risk;Role;Sampling;Short-Term Memory;Sleep;sleep behavior;Sleep Deprivation;Sodium;Testing;theories;Time;trait;Visit;Vulnerable Populations;Weight;Weight Gain;Weight maintenance regimen

PROJECT_TITLE: A prospective examination of sleep, eating behavior, and weight gain among overweight adults


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Tau protein undergoes abnormal and pathological accumulation in neurodegenerative diseases such as Alzheimer’s disease and frontotemporal dementia. Tau is a multifunctional protein, expressed in multiple cell types within the central nervous system. In this study, we will use hiPSC-derived neural cells and cortical organoids to examine how loss of tau function affects key neurodegenerative phenotypes including neuroimmune pathways, cellular stress and DNA damage, and neuronal electrophysiological function.

PI_NAMEs: YOUNG, JESSICA ELAINE (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Arsenites;Astrocytes;Binding;Binding Proteins;biological adaptation to stress;Cell Cycle;Cell Line;Cell membrane;Cell Nucleolus;Cell Nucleus;Cell Physiology;cell type;Cells;Cellular Stress;Central Nervous System;Coculture Techniques;Conditioned Culture Media;CRISPR/Cas technology;Cytoskeleton;Data;Deposition;differentiation protocol;DNA Damage;DNA Transposable Elements;dominant genetic mutation;Double-Stranded RNA;Electrophysiology (science);Elements;Etoposide;experimental study;Frontotemporal Dementia;Functional disorder;gain of function;Gene Expression Regulation;Genetic Transcription;genome editing;Genotype;Goals;Heat shock proteins;Hippocampus;Human;Human Cell Line;human induced pluripotent stem cells;hyperphosphorylated tau;immunocytochemistry;Immunoprecipitation;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;induced pluripotent stem cell technology;Inflammatory;Inherited;knock-down;Knock-out;Knockout Mice;Laboratories;Lead;lentiviral-mediated;Link;Long-Term Potentiation;loss of function;MAPT gene;Measures;Microtubule Stabilization;Microtubules;Molecular;multi-electrode arrays;Mus;Mutation;Nerve Degeneration;neural;neuroblastoma cell;Neurodegenerative Disorders;neurodegenerative phenotype;Neurofibrillary Tangles;Neuroglia;Neuroimmune;Neurons;neuropathology;novel;Organoids;Pathologic;Pathway interactions;Phase;Phenotype;Physical condensation;Physiological;Play;protein function;Proteins;Quantitative Reverse Transcriptase PCR;Rattus;Reading Frames;Regulation;Reporting;Reproducibility;response;RNA Binding;RNA metabolism;Rodent Model;Role;single-cell RNA sequencing;small hairpin RNA;stress granule;tau aggregation;tau expression;tau function;tau interaction;tau Proteins;Techniques;Testing;transcriptome;transcriptomic profiling;Transformed Cell Line;Transmembrane Transport;Up-Regulation;Work

PROJECT_TITLE: Functions of Tau protein in human neural cells

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE There is an urgent need to develop biologically relevant, scalable systems for the functional analysis of neurodevelopmental and psychiatric disorder (NPD) genes to advance from gene discovery to biological targets. We propose to establish an Assay and Data Generation Center as part of the SSPsyGene Consortium to screen 250 NPD genes in parallel and develop innovate assays for multi-omics screens. Our overarching goal is to gain new insights into the function of NPD genes and advance our understanding of the biology of these disorders.

PI_NAMEs: BRENNAND, KRISTEN JENNIFER;FAN, RONG ;HOFFMAN, ELLEN J (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 3-Dimensional;Affect;Arousal;autism spectrum disorder;Behavior;Behavioral;behavioral pharmacology;behavioral phenotyping;Biological;Biological Assay;Biology;Brain;brain cell;cell type;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Coupled;CRISPR screen;Data;data integration;Databases;Development;Disease;epigenomics;Estrogens;gene discovery;Gene Expression Regulation;gene function;Generations;Genes;Genetic;Genetic Transcription;genomic data;Genomics;Germ Lines;Goals;Human;Human Engineering;human induced pluripotent stem cells;In Vitro;in vivo;in vivo evaluation;Induced pluripotent stem cell derived human neuron;innovation;insight;Link;loss of function;Maps;Mental disorders;Methods;Molecular;multiple omics;mutant;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;Neurons;neuropsychiatric disorder;novel;Nuclear Pore Complex;Optics;Organoids;Outcome;Pathway interactions;Phenotype;Resources;risk variant;Role;screening;Sensory;Series;single cell sequencing;single-cell RNA sequencing;Structure;System;Technology;Time;tool;tool development;transcriptomics;Zebrafish

PROJECT_TITLE: High-throughput in vivo and in vitro functional and multi-omics screens of neuropsychiatric and neurodevelopmental disorder risk genes


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Eating Disorders;Mental Health;Nutrition;Obesity;Prevention

PI_NAMEs: KERVER, GAIL A. (contact)

PROJECT_TERMS: bariatric surgery;Binge eating disorder;biobehavior;Biological;biopsychosocial;Blood Glucose;Body Weight;Body Weight decreased;clinically relevant;clinically significant;comorbidity;Data;Eating;Eating Behavior;Eating Disorders;effective intervention;Environment;experience;Hypoglycemia;Impairment;improved;Individual;insight;Intervention;Link;loss of control over eating;Measures;Mediating;Mediation;Medical;Methods;Modeling;Morbid Obesity;negative affect;negative emotional state;Neurocognitive;novel;Obesity;Operative Surgical Procedures;Outcome;Pathologic;Patient Self-Report;Patients;physical conditioning;Population;Process;prospective;prospective test;psychologic;psychological distress;Psychology;Psychopathology;Public Health;Quality of life;Questionnaires;Research;Research Personnel;Resolution;Self-control as a personality trait;Testing;Time;Weight;weight loss intervention

PROJECT_TITLE: Momentary Bio-Behavioral Predictors of Loss of Control Eating and Weight Outcomes


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Obesity;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Non-alcoholic steatohepatitis (NASH) is a major global health concern that continues to rise at an alarming rate driven by the tide of the obesity pandemic. We propose that the BCKA regulatory network in liver is an important regulator of NASH pathogenesis. In this proposal we will explore the impact of modulating the components of the BCKA regulatory network on NASH development and further define the mechanism of action.

PI_NAMEs: WHITE, PHILLIP J (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Acute Liver Failure;adenoviral mediated;Adenoviruses;amino acid metabolism;Animals;ATP Citrate (pro-S)-Lyase;bariatric surgery;benign state;Body Weight;Branched-Chain Amino Acids;Cardiovascular Diseases;CD36 Antigens;CD36 gene;Cell Death;Cirrhosis;cohort;Deposition;Development;Eating;Enzymes;Etiology;Fibrosis;Follow-Up Studies;global health;Health;Hepatic;Hepatocellular Damage;Hepatocyte;Human;Incidence;Individual;Inflammation;inhibitor;insight;Keto Acids;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;Liver diseases;Liver Failure;Mediating;Medicine;Metabolic Diseases;Modeling;Molecular;Morbid Obesity;mouse model;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Obesity;overexpression;oxidation;Oxidoreductase;pandemic disease;Pathogenesis;Pathologic;Pathway interactions;Patients;Persons;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physical activity;Primary carcinoma of the liver cells;Printing;Protein Dephosphorylation;Protein phosphatase;Rattus;Recombinants;Reporting;Risk;Risk Factors;Serine;simple steatosis;small molecule inhibitor;Testing;Therapeutic;Thinness;Translations;Triglycerides;United States;uptake;Viral hepatitis;Wistar Rats;Work

PROJECT_TITLE: Mechanisms linking the Branched-Chain alpha-Keto Acid regulatory network to the pathogenesis of NASH

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE A national challenge in the biomedical sciences, and especially translational science/research, is recruiting, training, and retaining the most diverse scientific talent pool possible. At the UU CTSI, we are poised to tackle this challenge by leveraging recent successes at the UU in recruiting underrepresented students to our graduate programs and redoubling our efforts to develop targeted training and pipeline programs for underrepresented students to strengthen our applicant pool for translational science-related graduate programs. We will expand the Biomedical Research Inclusion & Diversity to Grow Excellence in Science – Undergraduate Program for Historically Black Colleges and Universities (HBCUs), and solidify key relationships with our local community and HBCUs to foster an inclusive, research-intensive environment where underrepresented scientists can flourish and attain their goal of admission to top-notch graduate training programs.

PI_NAMEs: FAGERLIN, ANGELA ;FAIRFAX, KEKE CELESTE (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Address;Admission activity;African American student;Biomedical Research;biomedical scientist;Black American;Black Populations;Black race;Cardiovascular Diseases;career;Career Choice;career networking;Clinical;clinical care;Clinical Research;Clinical Sciences;college;Communication;Communities;Critical Thinking;cultural competence;Data;Dedications;design;Development;Diabetes Mellitus;Disadvantaged;Discipline;Discrimination;diversity and inclusion;Doctor of Philosophy;Early Intervention;Education Projects;Educational workshop;empowerment;End stage renal failure;Environment;equity, diversity, and inclusion;expectation;experience;Exposure to;Faculty;faculty research;Family;Fortification;Fostering;Foundations;Friends;Goals;Graduate Education;graduate school;Growth;health disparity;High School Student;Hispanic;Historically Black Colleges and Universities;Home;improved;Infrastructure;innovation;Institution;interest;Knowledge;Leadership;Learning;Life;Malignant Neoplasms;matriculation;Mentors;Mentorship;Minority-Serving Institution;Mission;Modeling;North Carolina;notch protein;Oral;Outcome;Pathology;Patient-Focused Outcomes;peer;peer coaching;Physicians;Population;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Prevalence;Privatization;programs;Race;recruit;Research;Research Project Grants;Research Training;resilience;Role;role model;Science;Scientist;skill acquisition;skills;STEM career;Student recruitment;Students;success;summer program;Syndrome;Talents;Technical Expertise;tool;Training;Training Programs;Translational Research;translational research program;undergraduate research;undergraduate student;Underrepresented Students;Universities;Utah;Workplace;Writing

PROJECT_TITLE: CTSA R25 Program at University of Utah: Biomedical Research Inclusion & Diversity to Grow Excellence in science Undergraduate Program for HBCUs (BRIDGE UP–HBCU)


NIH_SPENDING_CATS: Cardiovascular;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Despite improved reperfusion strategies decreasing mortality in non-diabetic patients after acute MI, both prevalence and severity of ischemic heart failure continually escalate in type 2 diabetic patients, via incompletely understood mechanisms. The current application endeavors to define molecular mechanisms responsible for the pathologic communications between diabetic adipocytes and coronary microvascular endothelial cells. Successful completion of this proposal will identify novel therapeutic strategies capable of blocking/preventing exosome-mediated pathological communications between adipose tissue and heart (two organs critically involved in the development of type 2 diabetes and the death in this population, respectively), to ultimately ameliorate morbidity and mortality associated with diabetic cardiovascular complications.

PI_NAMEs: WANG, YAJING  (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Acceleration;Acute;Acute myocardial infarction;Adipocytes;adipokines;adiponectin;Adipose tissue;Affect;Attenuated;cardioprotection;cardiovascular injury;Cardiovascular system;Cell Communication;Cells;Cessation of life;Communication;Coronary;Coronary Circulation;cytotoxic;Data;Development;Diabetes Mellitus;diabetic;diabetic patient;Disease;effective intervention;effective therapy;Endocytosis;Endothelial Cells;Endothelium;exosome;experimental study;extracellular vesicles;Functional disorder;gain of function;Genetic;GRK5 gene;Health;Heart;Heart failure;Hemostatic function;Human;improved;in vivo;Injury;intravenous administration;Knowledge;Label;loss of function;Mediating;Metabolic;Microvascular Dysfunction;Molecular;Morbidity - disease rate;mortality;Myocardial Ischemia;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;novel therapeutics;Organ;overexpression;Pathologic;Patient Care;Patients;Persons;Phenotype;Phosphorylation;Phosphotransferases;Play;Population;Prevalence;prevent;Production;Publishing;receptor;Regulation;Reperfusion Therapy;Reporting;Research;Risk Factors;Role;Severities;Signal Transduction;Surface;System;Testing;Tissues;Type 2 diabetic;uptake;Vascular Endothelial Cell;Virulence Factors;Work

PROJECT_TITLE: Critical Role of Small Extracellular Vesicles in Diabetic Coronary VascularDysfunction and Diabetic Ischemic Heart Failure efforts

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Coronaviruses;Infectious Diseases;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative  B cell populations infiltrating the central nervous system (CNS) are common hallmarks of neurotropic infections, the demyelinating disease multiple sclerosis (MS), as well as autoimmune encephalitis. However, their antibody-independent regulatory functions and crosstalk with resident meningeal stromal cells, which provide the platform for chronic B-cell aggregates associated with immune pathology in MS, require more extensive investigation. Using a viral CNS infection model to characterize cues associated with acute, resolving, and chronic activation of meningeal stromal cells and their effects on B-cell retention and function, results will unveil how meningeal immune responses can be manipulated to optimize parenchymal protective immunity and/or minimize pathology.

PI_NAMEs: BERGMANN, CORNELIA  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Abbreviations;Ablation;Acute;acute infection;adaptive immune response;Anti-Inflammatory Agents;Antibodies;Antigen-Presenting Cells;Antigens;antimicrobial;Area;Autoantigens;Autoimmune;Autoimmune encephalitis;Autoimmunity;B cell differentiation;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Biological Assay;Blood Vessels;CCL19 gene;CCL21 gene;Cell Aggregation;Cell Communication;Cell Maturation;cell type;Cells;Central Nervous System;Central Nervous System Infections;Central Nervous System Viral Diseases;chemokine;Chronic;chronic infection;chronic inflammatory disease;Coronavirus;Cues;CXCL13 gene;cytokine;Demyelinating Diseases;Demyelinations;disability;Disease;enzyme linked immunospot assay;Experimental Models;Flow Cytometry;Goals;Heterogeneity;Histologic;Histology;Human;Immune;immune activation;Immune response;Immunity;Immunoglobulin Class Switching;Immunoglobulin D;Immunoglobulin M;Immunoglobulin-Secreting Cells;Immunoglobulins;Immunomodulators;improved;Infection;Infiltration;Inflammation;Integral Membrane Protein;Integrins;Intercellular adhesion molecule 1;Interleukin-13;interleukin-22;Investigation;Knowledge;Leukocytes;lymph nodes;Lymphoid;lymphotoxin beta;lymphotoxin beta receptor;Mediating;Mediator;Memory B-Lymphocyte;Meningeal;Meninges;microbial;migration;Modeling;MS4A1 gene;Mucins;Multiple Sclerosis;multiple sclerosis patient;Murine hepatitis virus;Neuromyelitis Optica;neurotropic;novel strategies;Organ;Pathogenicity;Pathologic;Pathology;Peripheral;Phase;Play;podoplanin;Population;Positioning Attribute;Receptor Signaling;Recombinants;recruit;Regulation;Research;Resolution;response;Reticular Cell;Role;scaffold;secondary lymphoid organ;Shapes;Signal Transduction;Site;Specificity;Stromal Cells;Structure;Structure of germinal center of lymph node;tertiary lymphoid organ;Testing;tissue injury;Tissues;Tumor Necrosis Factor-Beta;Up-Regulation;vector;Viral;Viral hepatitis;Viral Physiology;viral RNA;Virus;Virus Diseases

PROJECT_TITLE: Regulation of B cells in the CNS

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]