NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: INDIANAPOLIS

ORG_NAME: AMERICAN SOCIETY OF PREVENTIVE ONCOLOGY, INC.

ORG_STATE: IN

PHR: Project Narrative - Public Health Relevance The American Society of Preventive Oncology (ASPO) is a distinctive society that emphasizes multidisciplinary approaches to cancer prevention and control research. ASPO fulfills a unique niche enhancing the health of the public and supporting the continued development of investigators involved in cancer prevention and control. This application requests partial support—including travel funds for minority and early career investigators and community scientists/patient advocates—for ASPO’s 48th Annual Meeting, to be held at the Swissôtel Chicago, March 17-19, 2024. The events and activities available at ASPO’s 2024 Annual Meeting will influence scientific collaboration and cancer communications and community engagement beyond the conference.

PI_NAMEs: KINNEY, ANITA Y. (contact)

PROGRAM_OFFICER_NAME: WANG, WENDY

PROJECT_TERMS: Advertisements;Advocate;American;Anniversary;Area;Award;Back;Biological Markers;Cancer Burden;Cancer Center;Cancer Control;Cancer Control Research;cancer epidemiology;cancer prevention;Cancer Survivorship;career;career development;Chemoprevention;Chicago;Collaborations;collaborative environment;Committee Membership;Communication;Communities;Community Clinical Oncology Program;community engagement;community science;Dedications;demographics;design;Development;Discipline;diversity and inclusion;Educational workshop;Electronic Mail;energy balance;Event;Fostering;Funding;Future;Goals;Grant;Health Professional;individualized prevention;innovation;Institution;interdisciplinary approach;Intervention;Journals;Leadership;lectures;Malignant Neoplasms;Manuscripts;meeting reports;meetings;member;Mentors;Minority;minority investigator;Mission;multidisciplinary;non-smoking;novel;Oncology;Paper;Participant;Patients;Peer Review;Policies;posters;Prevention;Preventive;Primary Prevention;programs;Public Health;public health relevance;public policy on tobacco;Publishing;Request for Applications;Research Personnel;Research Proposals;Role;satisfaction;Scientific Advances and Accomplishments;Scientist;Screening for cancer;Secondary Prevention;social health determinants;Societies;special interest group;success;Surveys;symposium;tertiary prevention;Thinking;Tobacco Use Cessation;Training;training opportunity;Translating;Translations;Travel;Update;webinar

PROJECT_TITLE: 2024 Annual Conference Grant: American Society of Preventive Oncology

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Precision Medicine;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: AUSTIN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative There is an urgent need to address the current public health crisis of opioid abuse and overdose deaths through development of effective treatments for opioid use disorder and non-addictive therapeutics to manage pain. To this end, we are using human cells to create an ex-vivo model that recapitulate key features of neurobiology underlying the addictive process for opioid use disorder research. We anticipate the technological innovations to provide crucial tools for development of new therapeutics which can effectively combat the opioid crisis.

PI_NAMEs: SEIDLITS, STEPHANIE KRISTIN;YEH, HSIN-CHIH  (contact)

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: 3-Dimensional;3D Print;Achievement;Action Potentials;Acute;addiction;Address;Agonist;Animal Model;Animals;Automobile Driving;awake;Behavior;Biocompatible Materials;Biological Models;bioprinting;bioscaffold;Brain;Brain region;brain tissue;Cell Nucleus;Cells;chronic pain management;combat;Complex;Consumption;COVID-19 pandemic;Dangerousness;Detection;Development;Dimerization;Disease;Dopamine;effective therapy;Engineering;experimental study;Extracellular Matrix;Fentanyl;Fluorescence;fluorescence lifetime imaging;gamma-Aminobutyric Acid;Glutamates;Goals;healing;High Pressure Liquid Chromatography;Human;human induced pluripotent stem cells;human model;illicit opioid;Image;imaging modality;imaging system;improved;in vitro Model;in vivo;individualized medicine;innovation;interest;Lasers;manufacture;Maps;Measurement;Methods;Microscopy;Midbrain structure;mimetics;Modeling;molecular imaging;Monitor;multiplex detection;neural network;Neurobiology;neuronal circuitry;Neurons;neurophysiology;neurotransmitter release;Neurotransmitters;new technology;novel;novel therapeutics;Nucleus Accumbens;Opioid;opioid abuse;opioid epidemic;opioid exposure;opioid mortality;Opioid Receptor;opioid use disorder;Optics;optogenetics;overdose death;Pain management;pain relief;Pathway interactions;patient derived induced pluripotent stem cells;Patients;personalized medicine;Prevalence;Printing;Process;Production;Proteins;Public Health;Reproducibility;Research;Research Personnel;Resources;response;reward circuitry;Rewards;Rodent Model;sample collection;Sampling;scaffold;single molecule;small molecule therapeutics;Substance abuse problem;Surface;Synapses;Synaptic Transmission;Techniques;technological innovation;Technology;temporal measurement;Therapeutic;therapy development;three dimensional cell culture;Time;Tissue constructs;Tissue Engineering;Tissue Model;Tissues;tool development;transmission process;two-dimensional;Ventral Tegmental Area;Visualization;Work

PROJECT_TITLE: Studying synaptic transmission under opioid exposure using hiPSC-derived midbrain model and hyperspectral fluorescence lifetime imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-N (J1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Estrogen;Heart Disease;Heart Disease - Coronary Heart Disease;Liver Disease;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Obesity has dramatically increased the burden of cardiovascular disease, and a major goal of the NIH/NHLBI is to reduce this burden. The goal of this application is to discover how a lipid transfer protein called CETP influences the liver pathways that improve glucose and lipid abnormalities in obesity, which is expected to help reverse the impact of obesity on cardiovascular risk. Our project also identifies pathways that mediate sex- differences in cardiovascular disease, which is also an NIH priority area.

PI_NAMEs: STAFFORD, JOHN MICHAEL (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Acceleration;Acids;Adipose tissue;Age;Agonist;Androgen Receptor;Androgens;Area;Atherosclerosis;Bile Acids;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cholesterol;Cholesterol Esters;Cholesterol Homeostasis;Closure by clamp;Coronary heart disease;Dependence;Development;Diabetes Mellitus;diabetes risk;Dyslipidemias;estrogenic;Estrogens;fatty acid metabolism;Fatty Acids;Fatty Liver;fatty liver disease;Female;Funding;gain of function;Glucagon Receptor;Glucose;glucose metabolism;Goals;Gonadal Steroid Hormones;Health;heart disease risk;Hepatic;High Density Lipoprotein Cholesterol;High Density Lipoproteins;high risk;high risk men;hormonal signals;Human;Hyperinsulinism;Hypertension;improved;innovation;knock-down;Knowledge;LDL Cholesterol Lipoproteins;Life;lipid metabolism;lipid transfer protein;Lipids;Liver;male;Measures;Mediating;Mediator;men;Messenger RNA;Metabolic;Metabolic Diseases;metabolic rate;Metabolism;Modeling;muricholic acid;Mus;Muscle;National Heart, Lung, and Blood Institute;novel;Nutrient;Obesity;Ovariectomy;overexpression;Pathway interactions;Physiology;preservation;protein expression;Protein Overexpression;Proteins;Regulation;response;Risk;Risk Factors;risk sharing;Rodent;sex;Sex Differences;Signal Transduction;Skeletal Muscle;species difference;Sterols;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Tracer;transgene expression;Transgenic Mice;Translating;translational barrier;Triglyceride Metabolism;Triglycerides;United States National Institutes of Health;Woman

PROJECT_TITLE: Sex-Specific Risk of Metabolic and Cardiovascular Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-B (02)]


ADMINISTERING_IC: MH

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness

ORG_CITY: HOUSTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: Narrative Black adults are disproportionately impacted by serious mental illness (SMI) and are known to underutilize formal mental health services, often seeking support to manage their mental health outside formal settings, creating unique pathways to mental health recovery. The recovery processes among Black adults with SMI are understudied, contributing to a lack of understanding of how they experience recovery through multiple pathways, including formal care (therapy and medication), informal support (peer support, family, faith-based), and personal recovery (self-management) and how these pathways promote and facilitate their recovery processes. The goal of this study is to explore the process of recovery among Black adults with SMI and examine how professional and informal help seeking leads to recovery.

PI_NAMEs: BROWN, MARCUS D (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;Adult;adverse outcome;aged;Black race;Caring;Communities;Critical Pathways;Data Analyses;Data Collection;Death Rate;Dimensions;disability;Discrimination;Disease remission;Disparity;empowerment;experience;Faith;Family;Future;Goals;Health Care Costs;help-seeking behavior;improved;Individual;informal care;informal support;Intervention;Interview;Life;Mental Health;Mental Health Services;Modeling;National Institute of Mental Health;optimism;Outcome;Pathway interactions;peer;peer support;Personal Satisfaction;Pharmaceutical Preparations;phenomenological models;Population;preference;Process;Quality of life;racism;Recovery;recruit;Research;Research Design;Research Personnel;Resources;Sampling;Science;Self Management;Services;severe mental illness;Shapes;Socioeconomic Factors;stem;Strategic Planning;Structure;symptom management;Symptoms;System

PROJECT_TITLE: Pathways to Mental Health Recovery among Black Adults with Serious Mental Illness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Central obesity, diabetes, and metabolic syndrome are leading causes of morbidity and mortality worldwide, and metabolic traits related to these diseases have a strong inherited basis. The proposed work will identify DNA variants that influence these traits and mechanisms by which the variants regulate gene expression in cells and alter trait levels. The results may lead to improved disease diagnosis and treatment.

PI_NAMEs: MOHLKE, KAREN L. (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Acceleration;adipocyte differentiation;Adipocytes;Adipose tissue;advanced analytics;Affect;Alleles;analytical method;Binding;Biological;Biological Assay;Buffers;Candidate Disease Gene;causal variant;Cell Physiology;cell type;Cells;Cellular Assay;Central obesity;Cholesterol;Chromatin;Clinical;Complex;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Detection;Development;Diabetes Mellitus;Diagnosis;Disease;disease diagnosis;disorder risk;Distal;DNA;energy balance;Enhancers;epigenomics;Exhibits;exome;experimental study;Frequencies;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Gene Frequency;gene function;Genes;Genetic;genetic epidemiology;Genetic study;Genetic Transcription;genome editing;genome sequencing;genome wide association study;Genotype-Tissue Expression Project;Goals;high throughput screening;high throughput technology;human tissue;improved;Individual;Inherited;innovation;Insulin;Leptin;Link;Lipids;Mediating;men;Mendelian randomization;Meta-Analysis;Metabolic;Metabolic Diseases;Metabolic syndrome;Minor;Molecular;Morbidity - disease rate;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel;obesity treatment;Participant;Pathogenicity;Phase;Plasma;Quantitative Trait Loci;Recommendation;Regulator Genes;Regulatory Element;Reporter;Resources;Risk;RNA Splicing;Role;Sample Size;Signal Transduction;single cell genomics;single nucleus RNA-sequencing;Specific qualifier value;subcutaneous;success;Testing;Text;tissue resource;Tissues;trait;transcription factor;transcriptome sequencing;transcriptomics;Translating;Triglycerides;Untranslated RNA;Variant;variant detection;Waist-Hip Ratio;whole genome;Work

PROJECT_TITLE: Genetic epidemiology of rare and regulatory variants for metabolic traits

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Genetics

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative Mutagenesis, changes in the DNA which can occur due to endogenous cellular event and environmental stresses, has wide-ranging impacts from the development of cancer and aging to the acquisition of antibiotic resistance in microorganisms. This meeting will bring together scientists from various countries from a wide range of disciplines to discuss the fundamental mechanisms driving mutagenesis across species. We aim to promote cross-field fertilization of ideas, the establishment of new collaborations, and based on what we are learning at the fundamental level, ultimately, the identification of potential new avenues for therapeutic intervention.

PI_NAMEs: MERRIKH, HOURA  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: adaptive immunity;Aging;aging related disease;anti-cancer therapeutic;Antibiotic Resistance;Antibodies;Antimicrobial Resistance;Architecture;Area;Automobile Driving;Bacteria;Bioinformatics;Biological Models;Biology;Biophysics;cancer cell;cancer therapy;Carcinogenesis Mechanism;career;cell behavior;Cells;chromosome replication;Clinical;Collaborations;commune;Communication;Communication difficulty;Communities;Country;Dedications;deep sequencing;Development;Discipline;Disease;DNA;DNA Damage;DNA Repair;DNA replication fork;DNA Sequence;Ensure;Environment;environmental mutagens;environmental stressor;Event;Evolution;Feeling;Fellowship;Fertilization;fighting;Fostering;Friends;Funding Opportunities;Genetic;Genetic Transcription;Genomic Instability;Genomics;global health;graduate student;Health;Hour;Human;Immunoglobulin Genes;Invaded;Invertebrates;Learning;Lesbian Gay Bisexual Transgender;Link;Location;Malignant Neoplasms;Mammalian Chromosomes;Mammals;meetings;Mentors;microorganism;Minority;Modernization;Molecular;Mutagenesis;Mutation;New Hampshire;next generation;Oral;Organism;pathogen;Pathologic;Play;Postdoctoral Fellow;posters;Process;programs;Proliferating;recruit;repaired;Research;Research Personnel;Resistance;Resistance development;Rural;Science;Scientist;Series;single molecule;Site;social;success;symposium;Techniques;Therapeutic Intervention;Time;trait;Underrepresented Minority;Viral;Woman;Work;Yeasts

PROJECT_TITLE: 2024 Mutagenesis Gordon Research Conference and Seminar


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Orphan Drug;Rare Diseases

PHR: Project Narrative Membrane transporters move ions, metabolites, nutrients, neurotransmitters and therapeutic drugs that are central to both life and death, into and out of cells and organellar compartments. They are the clinically relevant targets of blockbuster drugs to treat widespread diseases like diabetes, cancer and depression, as well as orphan diseases and rare genetic disorders. The 2024 Gordon Research Conference on Membrane Transporters titled “New Insights into Structure, Function, and Regulation of Critical Membrane Transport Proteins in Health and Disease” will bring together scientists from industry, academia and government to focus on translating advances in basic science to therapies that benefit numerous patients.

PI_NAMEs: INGRAM, SUSAN L (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Academia;Advocate;Animal Model;Anniversary;autism spectrum disorder;Award;Basic Science;Biochemical;Biological;biophysical analysis;Biophysics;career;Carrier Proteins;Cells;Cessation of life;Chlorides;Christianson syndrome;Climate;Clinical;clinically relevant;Collaborations;Communities;Cultural Backgrounds;Cystic Fibrosis;Data;design;Development;Diabetes Mellitus;Discipline;Disease;Disparate;Diuretics;diversity and inclusion;Drug Targeting;Ensure;Environment;Episodic ataxia;equity, diversity, and inclusion;ethnic diversity;Europe;Event;Fluoxetine;Functional disorder;Future;Genes;Genetic;Goals;Government;graduate student;Health;Health Sciences;Hour;human disease;Human Genome;Industry;innovation;insight;International;Ion Channel;Ion Pumps;Ions;Leadership;Life;Link;Lipids;Malignant Neoplasms;medical schools;Medicine;meetings;Membrane Potentials;Membrane Transport Proteins;Mental Depression;Mentors;Metabolic Diseases;Metabolism;Microbe;mid-career faculty;Mind;Molecular;Nervous System Disorder;Neurotransmitters;notch protein;novel;Nutrient;Obesity;Omeprazole;Organism;outreach;Participant;pathogen;Patients;peer;Perception;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Physiological;Physiology;Plants;Policies;Postdoctoral Fellow;posters;prevent;professor;programs;Protein translocation;Proteins;Proton Pump;Publishing;Pump;Rare Diseases;rare genetic disorder;recruit;Regulation;Reporting;Research;Research Personnel;Schizophrenia;Science;Science, Technology, Engineering and Mathematics;Scientist;Secure;Selective Serotonin Reuptake Inhibitor;serotonin transporter;Sex Orientation;single-molecule FRET;SK-Furosemide;skills;Sodium;structural biology;Structure;Students;success;successful intervention;supportive environment;symporter;symposium;System;Texas;Therapeutic;therapeutic target;Time;Tissues;trafficking;Transcranial magnetic stimulation;Translating;Transmembrane Transport;Travel;Ulcer;Underrepresented Minority;United States National Institutes of Health;Universities;Widespread Disease;Woman;Work

PROJECT_TITLE: 2024 Membrane Transport Proteins Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (43)]


ORG_CITY: PHOENIX

ORG_NAME: TRANSLATIONAL GENOMICS RESEARCH INST

ORG_STATE: AZ

PHR: NARRATIVE Work from our group and others over the past decade leads us to conceptualize that progressive pulmonary fibrosis is the last of three distinct stages of disease pathogenesis, starting from a point of sub-radiographic molecular pathology through progressive radiologically detectable presymptomatic disease, culminating in progressive, symptomatic pulmonary fibrosis. Leveraging samples from individuals across the complete spectrum of PF pathogenesis, together with formalin-fixed, paraffin-embedded (FFPE)-capable, state-of-the-art single-cell and spatial transcriptomic technologies, we will establish a deep understanding of the identity, sequence, and spatial coordination of the molecular mechanisms that drive disease pathogenesis across these stages of PF progression.

PI_NAMEs: BANOVICH, NICHOLAS ELI (contact);KROPSKI, JONATHAN ANDREW

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: advanced disease;Alveolar;Archives;Biology;Blood capillaries;cell type;Cells;Clinical;Data;Data Set;Disease;Disease Progression;end stage disease;Evolution;Extracellular Matrix;Fibroblasts;Fibrosis;Formalin;Funding;Future;Gases;Genes;Genetic;Genetic Variation;Genomics;Genotype;Heterogeneity;Human;Hypoxia;idiopathic pulmonary fibrosis;Individual;insight;Link;Lung;Mediating;Molecular;molecular pathology;Morbidity - disease rate;mortality;Natural History;novel;Outcome;Paraffin Embedding;Pathogenesis;Pathologic;Pathway interactions;Patients;Positioning Attribute;pre-clinical;Precision therapeutics;primary outcome;Primary Prevention;Production;programs;Pulmonary Fibrosis;radiological imaging;Radiology Specialty;Regulation;Respiratory Failure;Role;Sampling;Secondary Prevention;Severities;single-cell RNA sequencing;spatiotemporal;Structure of parenchyma of lung;Surface;Syndrome;targeted treatment;Technology;Therapeutic;Tissue Sample;Tissues;transcriptomics;Work

PROJECT_TITLE: Spatiotemporal genomic regulation of disease initiation and progression in pulmonary fibrosis


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Genetics;Human Genome;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PHR: NARRATIVE Multiple sclerosis is a debilitating autoimmune disease resulting from damage to the brain and spinal cord leading to neurological impairment and death. Relapsing-remitting multiple sclerosis (RRMS) is the most common type of multiple sclerosis and is defined by attacks (relapses or flares) of new or increasing neurologic symptoms followed by periods of partial or complete remission. The proposed studies are focused on understanding how changes in chromatin accessibility affect T cell function and lead to disease flares in RRMS.

PI_NAMEs: BUCKNER, JANE HOYT (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: 3-Dimensional;Address;Affect;analysis pipeline;ATAC-seq;Autoimmune Diseases;biobank;Biological Markers;Brain;CD4 Positive T Lymphocytes;Cell Lineage;Cell Physiology;cell type;Central Nervous System;Cessation of life;Chromatin;chromatin modification;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;cytokine;Data;Data Set;Demyelinations;Development;Disease;Disease remission;DNA Methylation;Enhancers;Environmental Risk Factor;epigenome;epigenomics;experience;Flare;foot;Functional disorder;Funding;Future;Gene Expression;gene network;Genes;Genetic;Genetic Risk;genome wide association study;genome-wide analysis;Genomics;Goals;Hi-C;high dimensionality;high reward;histone modification;Immune;Impairment;Individual;Inflammatory;insight;Investigation;Knowledge;Link;Longitudinal cohort;Memory;Modeling;Molecular;Multiple Sclerosis;Nerve Degeneration;Neurologic;Neurologic Symptoms;novel;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peptide Initiation Factors;Play;Printing;Process;Regulation;Regulatory T-Lymphocyte;Relapse;Relapsing-Remitting Multiple Sclerosis;Research;Role;Sampling;Spinal Cord;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Therapeutic Intervention;therapeutic target;tissue resident memory T cell;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Variant;XCL1 gene;ZFP36L2 gene

PROJECT_TITLE: T Cell Epigenomic Drivers of Disease Flares in Multiple Sclerosis

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Electronic Nicotine Delivery Systems;Pediatric;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: NARRATIVE In recent years, the rapidly growing number of teens who use e-cigarettes threatens to reverse the progress made in reducing teen smoking, not only in the United States but around the world. This study aims to better understand how teens’ peer networks at school, including their best friends and others with whom they communicate online, influence them to both start and continue to smoke and use e-cigarettes. By comparing Mexican and U.S. teens, the results will help find better ways to reduce teen smoking, e-cigarette use, and the health problems that they cause.

PI_NAMEs: LEAL CASTRO, DIEGO F.;THRASHER, JAMES  (contact)

PROGRAM_OFFICER_NAME: PARASCANDOLA, MARK

PROJECT_TERMS: Administrator;Adolescence;Adoption;Advocate;Affect;Alternative Therapies;Behavior;Behavioral;bullying;Calibration;California;cigarette advertising;cohort;combustible cigarette;Communication;comparative;Computer software;contextual factors;Country;Data;Data Analyses;Data Collection;data integration;design;Educational workshop;Electronic cigarette;electronic cigarette use;Ethnic Population;experience;experimental study;Family;Feedback;Foundations;Friends;Friendships;Future;Goals;Health;Health behavior;High School Student;Incidence;Individual;innovation;insight;Intervention;intervention effect;Latinx;Link;Literature;Los Angeles;Measures;member;Mexican;Mexico;model design;Modeling;models and simulation;Network-based;Nicotine;Parameter Estimation;Pathway Analysis;peer;peer influence;peer networks;Persons;Policies;preference;Prevalence;privacy protection;Process;public policy on tobacco;relative effectiveness;Reporting;Research;Research Personnel;Risk;Risk Behaviors;Risk Factors;Role;Schools;Science;Smoke;Smoking;social;social culture;social influence;social media;Social Network;Students;Surveys;System;Teenagers;Testing;theories;therapy design;Tobacco;Tobacco use;United States;user-friendly;virtual;virtual intervention;Youth

PROJECT_TITLE: Building Stochastic Actor-Oriented Models to investigate social network influences on youth nicotine product use transitions and to simulate different intervention effects across contexts

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ORG_CITY: ROCKVILLE

ORG_STATE: MD

PHR: The Annual Meeting of the American Society for Investigative Pathology offers a unique forum for the sharing of original research results related to a wide spectrum of human diseases and disorders, with particular emphasis on the development, treatment, and prevention of cancer. Such sharing fosters more rapid advances in the understanding of human diseases such as cancer and accelerates the rate at which this knowledge can be applied to the development of diagnostic and prognostic tests, as well as targeted therapies. A major goal of the meeting is to provide educational and career support to trainees and other young investigators who are interested in cancer biology and experimental pathobiology.

PI_NAMEs: COLEMAN, WILLIAM B (contact)

PROJECT_TERMS: Acceleration;American;Artificial Intelligence;Award;Baltimore;Basic Science;Biology;biomarker development;Biomedical Research;Body System;Breast Cancer Prevention;Cancer Biology;cancer prevention;Cardiovascular Pathology;career;career development;Cells;chronic liver disease;Clinical;Clinical Research;Collaborations;college;design;Detection;Development;Diagnosis;diagnostic development;Diagnostic tests;Disease;diversity and inclusion;Education;Educational Curriculum;Educational workshop;Ensure;Ethnic Origin;Exclusion;Experimental Pathology;Faculty;Feedback;Fostering;Functional disorder;Future;Gender;Goals;graduate student;Human;human disease;Individual;Institution;interest;Interest Group;Knowledge;Laboratory culture;Laboratory Research;lectures;Malignant neoplasm of liver;Malignant Neoplasms;Medical;meetings;member;Mentors;Metabolism;mid-career faculty;Obesity;Oxygen;Participant;Pathogenesis;Pathologist;Pathology;Physicians;Postdoctoral Fellow;posters;practical application;pre-doctoral;Prevention;Productivity;prognostic assays;programs;racial population;racism;Renaissance;Research;Research Personnel;Scientific Societies;Scientist;screening;Seasons;Secure;Signal Transduction;social;Societies;Special Event;Specimen;Suggestion;symposium;Systems Biology;targeted treatment;Technology;Therapeutic;Toxicology;transcriptomics;translational medicine;Translational Research;Woman;Work

PROJECT_TITLE: 2024 Annual Meeting of the American Society for Investigative Pathology


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: MILWAUKEE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: PROJECT NARRATIVE A major challenge to treating spinal cord injury and maximizing functional recovery is the sheer number of neural populations that carry brain-spinal information. To move beyond a tract-by-tract approach, this project harnesses new technology to survey the entirety of the affected cell types and then selectively manipulate genetically defined subsets, which will yield new insights into the injury and direct attention toward the most important sets of cells.

PI_NAMEs: BLACKMORE, MURRAY G (contact);TSOULFAS, PANTELIS

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: 3-Dimensional;Affect;Anatomy;Animals;Atlases;Axon;behavior test;Behavioral;Brain;Brain region;Brain Stem;Cell Nucleus;cell type;Cells;Clinical;cohort;Communication;Complement;Complex;connectome;Contusions;Data;data resource;Data Set;design;designer receptors exclusively activated by designer drugs;directed attention;Disease;Elements;experimental study;Forelimb;functional outcomes;functional restoration;Genetic;Genetic Enhancer Element;genetic manipulation;Genetic Transcription;Growth;hindbrain;Image;Individual;Injections;Injury;insight;Intention;interest;Knowledge;Label;learned behavior;Location;Measures;Methodology;Midbrain structure;Movement;neural;Neuroanatomy;Neurons;new technology;novel;Outcome;Output;Paralysed;partial recovery;Population;Pre-Clinical Model;prevent;Property;Prosencephalon;Recovery;Recovery of Function;Rehabilitation therapy;Residual state;Resources;Role;Severities;simulation;Site;Spinal;Spinal Cord;Spinal cord injury;Spinal Injuries;Surveys;Task Performances;Techniques;Testing;Three-Dimensional Imaging;Tissues;tool;Variant;vector;Viral;Visualization

PROJECT_TITLE: Global analysis of the supraspinal connectome after spinal cord injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE In this project, we will develop computational software and generate extensive datasets to study CRISPR (also called genome editing) experiments, which are intended to make precise changes in the DNA of living cells. The software will allow researchers to understand how DNA differences between people may change how CRISPR works, the spectrum of potential DNA changes that might result from different CRISPR methods, and compare how experimental parameters may influence these results. This project will help scientists and clinicians develop precise tools to change DNA sequences in living cells to treat a range of diseases.

PI_NAMEs: BAUER, DANIEL EVAN (contact);PINELLO, LUCA

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Address;African ancestry;Alleles;base editing;Basic Science;Benchmarking;beta Thalassemia;Biological Assay;Cell Line;Cells;Clinical;clinical application;clinical development;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computer software;computerized tools;Computing Methodologies;CRISPR therapeutics;CRISPR/Cas technology;Data Set;design;Development;Disease;disorder prevention;DNA;DNA Sequence;DNA sequencing;empowerment;Ensure;Enzymes;Equity;Event;Experimental Designs;experimental study;flexibility;gene-editing approach;Genes;genetic variant;Genome;genome editing;genome-wide;Genomics;Genotype;Goals;Graph;Heritability;Heterogeneity;Heterozygote;High-Throughput Nucleotide Sequencing;Homeostasis;Human;Human Genome;Individual;innovation;Knowledge;Mediating;Methodology;Methods;Modeling;Modification;Morphologic artifacts;novel;nuclease;off-target site;open source tool;Outcome;pan-genome;Pathology;Pathway interactions;Persons;Population;predictive tools;prevent;prime editing;rare variant;recombinase;reference genome;repaired;Reproducibility;Reproducibility of Results;Research;Research Personnel;Retinal blind spot;Risk Assessment;Safety;Scientist;Sickle Cell Anemia;simulation;Site;Specificity;Statistical Data Interpretation;Statistical Models;Technology;telomere;Testing;Therapeutic;therapeutic development;therapeutic genome editing;therapeutically effective;tool;Transposase;Treatment Efficacy;Variant;Work;Writing

PROJECT_TITLE: Computational tools for precision genome editing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (02)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Genetics;Heart Disease;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE The heart consists of multiple cell types, but how these different cell types interact to produce heart function is incompletely understood. An even more challenging problem is to determine the functional consequences of different subtypes within the same cell type – i.e. cardiac muscle cells with different patterns of gene expression. In this exploratory project, we will combine state-of-the-art sequencing technology with mechanistic mathematical modeling and functional cellular assays to predict the physiological consequences of multiple subtypes of cardiac muscle cells.

PI_NAMEs: SOBIE, ERIC A (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Address;Applications Grants;Behavior;Biological Assay;Biomedical Engineering;blood pump;Body System;Calcium;Cardiac;Cardiac Myocytes;Cell Separation;cell type;Cells;Cellular Assay;Characteristics;Computer Analysis;computerized tools;Computing Methodologies;Contracts;Coupling;Data;Development;Disease;Electrophysiology (science);Endothelial Cells;experimental study;Explosion;Fibroblasts;Fluorescent in Situ Hybridization;Gene Expression;Gene Expression Profile;gene function;Goals;Heart;Heart Diseases;heart function;Heart Research;Hematological Disease;Human;Immunofluorescence Immunologic;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;innovation;insight;interest;Link;Lung Diseases;Macrophage;mathematical model;Measurement;Measures;Methods;Modeling;Muscle Cells;new technology;Output;Phenotype;Physiological;Physiology;Pilot Projects;Population;predictive modeling;Publishing;Research;Research Personnel;response;Signal Transduction;simulation;single-cell RNA sequencing;Sleep Disorders;stem cells;Systems Biology;Techniques;Technology;Testing;Tissues;tool;Ventricular;Work

PROJECT_TITLE: Mechanistic modeling to link scRNAseq data to physiological predictions


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Regenerative Medicine

ORG_CITY: ALBANY

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: NARRATIVE: Although fibrosis contributes to 45% of all deaths in the US, whether fibrosis is reversible and thereby treatable is not known. In the study, we will compare a reversible model of fibrosis with a non-reversible model of fibrosis to identify biomarkers for reversible and non-reversible fibrosis. We will also examine cell mesenchymal stromal cell transplantation and secreted vesicles made by these cells to reverse fibrosis as a step towards development of better therapeutics for salivary gland diseases involving fibrosis.

PI_NAMEs: LARSEN, MELINDA  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Ablation;Aging;Alginates;Automobile Driving;biomarker identification;Cell Differentiation process;Cell secretion;Cell Transplantation;cell type;Cells;Cessation of life;Collagen;Collagen Fiber;Complex;defined contribution;Deposition;Development;Disease;drug discovery;Duct (organ) structure;Excision;exosome;Extracellular Matrix;Fibroblasts;Fibrosis;Foundations;functional restoration;Funding;Future;Genes;Gland;Head and Neck Cancer;healing;Histologic;Human;immune function;Impairment;improved;Injury;Ligation;Mass Spectrum Analysis;Mediating;Mesenchymal Stem Cell Transplantation;mesenchymal stromal cell;Modeling;Morbidity - disease rate;mortality;mouse model;Natural regeneration;novel therapeutics;Operative Surgical Procedures;Organ;organ growth;Organoids;Pathologic;Pathology;Patients;Pattern;PDGFRB gene;Platelet-Derived Growth Factor alpha Receptor;pleiotropism;Population;Proteins;Proteomics;Radiation therapy;Recovery;regeneration potential;regenerative;Regenerative Medicine;Regenerative response;regenerative therapy;regenerative tissue;Regulation;remediation;Resolution;response;restoration;Salivary;Salivary Gland Diseases;Salivary Glands;scaffold;Signal Transduction;single-cell RNA sequencing;Sjogren's Syndrome;Stress;System;Testing;Therapeutic;therapeutic development;therapeutic target;tissue repair;tool;trait;transcriptomics;Transforming Growth Factor beta;Transplantation;Vesicle;Work

PROJECT_TITLE: Remediating fibrosis for salivary gland regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (03)]


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: NARRATIVE Although revolutionary approaches with immune checkpoint blockade (ICB) have dramatically transformed the therapeutic landscape of cancer patients, ICB has had a limited impact on head and neck squamous cell carcinomas (HNSCC) where >80% of patients fail to respond. The objective of this proposal is to exploit the ability of specific chemokines to recruit and activate key anti-tumoral immune cells and dramatically potentiate ICB therapy for enhanced tumor elimination and durable responses. The underlying mechanisms for treatment success as well mechanisms that limit responsiveness will also be explored to inform future therapeutic strategies.

PI_NAMEs: GUTKIND, JORGE SILVIO  (contact);HANDEL, TRACY M

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: 9p21;advanced disease;Affect;Annual Reports;anti-PD-1;anti-tumor immune response;Antigen Presentation;Antitumor Response;Biological Assay;cancer cell;Cancer Patient;Cancer Prognosis;CD8-Positive T-Lymphocytes;Cell Communication;Cell secretion;cell type;Cells;Cessation of life;chemokine;chemokine receptor;chemotherapy;Chemotherapy and/or radiation;chromosome loss;Combined Modality Therapy;Communication;Coupled;CXC chemokine receptor 3;CXCL10 gene;CXCL9 gene;CXCR3 gene;cytotoxic;cytotoxic CD8 T cells;Data;Death Rate;Dendritic Cells;Disease;draining lymph node;Effector Cell;effector T cell;Exclusion;exhaustion;experimental study;Functional disorder;Future;G-Protein-Coupled Receptors;global health;Goals;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Proteins;Head and Neck Squamous Cell Carcinoma;HPV negative;HPV-negative head and neck cancer;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immune Evasion;Immunooncology;Immunosuppression;Immunotherapy;improved;Individual;Infiltration;Interferon Type II;Ligands;Link;Location;malignant mouth neoplasm;Malignant Neoplasms;Metastatic/Recurrent;Methods;molecular targeted therapies;mouse model;Natural Killer Cells;neoplastic cell;Newly Diagnosed;NK Cell Activation;novel;novel therapeutics;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Phenotype;Population;prevent;programmed cell death protein 1;programs;Property;Radiation;receptor;recruit;Resistance;resistance mechanism;response;Signal Transduction;Spatial Distribution;success;Survival Rate;System;T cell infiltration;T-Lymphocyte;targeted treatment;Therapeutic;Tobacco;trafficking;treatment effect;Treatment Efficacy;Treatment Failure;treatment response;tumor;Tumor Expansion;tumor growth;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;XCL1 gene;XCR1 gene

PROJECT_TITLE: Reprogramming the Tumor Immune Microenvironment with Chemokines to Potentiate Immune Oncology Treatments in Oral Cancer

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative Infection by the gram-negative pathogen Bordetella pertussis results in persistence in the human nasal cavity resulting in bacterial transmission and pertussis outbreaks. This research will advance the understanding of the mechanisms by which B. pertussis survives in the human nose and lead to the discovery of how both the bacterium and host adapt to the nasal cavity environment. Outcomes from this study will provide novel targets for next generation pertussis vaccines.

PI_NAMEs: DEORA, RAJENDAR K (contact);DUBEY, PURNIMA

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acellular Vaccines;Acute Disease;Address;Air;Animal Model;Animals;Bacteria;Biological Models;Bordetella pertussis;Cells;Child;chronic infection;Cilia;clinically relevant;Complex;Country;Disease;Disease Outbreaks;Environment;Epithelial Cells;Event;Gene Expression;Gene Expression Profile;Genetic Transcription;Goals;Gram-Negative Bacteria;Human;Human Characteristics;human model;human pathogen;Immune response;Immunity;Immunization;improved;Incidence;Individual;Infant;Infection;insight;Liquid substance;Lower respiratory tract structure;Methods;Microbial Biofilms;Morphology;Mucosal Immunity;Mucous body substance;Nasal cavity;Nasal Epithelium;Nasopharynx;next generation;Nose;novel;Outcome;Outcome Study;pathogen;Pathogenesis;Pertussis;Pertussis Vaccine;prevent;Process;Research;residence;Respiratory System;Role;Shapes;Surface;Symptoms;Technology;transcriptome;transcriptome sequencing;transmission process;Vaccination;Vaccinee;Virulence Factors

PROJECT_TITLE: Interaction of Bordetella pertussis with human nasal epithelium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-V (02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Obesity;Clinical Research;Genetics;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

PHR: Project Narrative Converging lines of evidence indicate that stress, and childhood adversity in particular, accelerates the aging process, leading to impairment, suffering, and disease. The proposed study examines the role of mitochondrial DNA deletions in this process, leveraging data available from a longitudinal study of children that includes rich data on exposures, aging biomarkers, and health behaviors and outcomes. Results of this study are expected to provide insight into the early development of biological alterations that may accelerate aging and risk for disease, and provide targets for new treatment and prevention approaches.

PI_NAMEs: PARADE, STEPHANIE HART;TYRKA, AUDREY  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: accelerated epigenetic aging;Adult;age acceleration;age related decline;age-related disease;Aging;aging biomarker;aging process;aging related;Animal Model;Animals;Atherosclerosis;Basal metabolic rate;Biological;biological adaptation to stress;biological development;Blood Pressure;Body mass index;Cardiovascular Diseases;Cell Aging;Cell Death;Child;Child Abuse and Neglect;Childhood;childhood adversity;Data;design;Development;Diabetes Mellitus;Diet;Disease;disorder risk;DNA analysis;DNA Markers;early childhood;early experience;early life adversity;early onset;Fatty acid glycerol esters;Glucocorticoids;Health;Health behavior;Health behavior and outcomes;Human;Impairment;Individual;Inflammation;Inflammatory;insight;Insulin Resistance;Intervention;Length;Life;Link;Lipids;Literature;Longitudinal Studies;Measurement;Measures;Mental disorders;Metabolic Pathway;Methodology;middle childhood;Mitochondria;Mitochondrial DNA;Neurosecretory Systems;novel;Obesity;Outcome;Pain;Participant;Pathway interactions;pediatric trauma;Physical activity;Play;poor health outcome;predictive modeling;Prevention approach;Process;prospective;Psychiatric Diagnosis;psychiatric symptom;Public Health;Reactive Oxygen Species;Risk;Risk Factors;Role;Saliva;Sampling;sedentary lifestyle;Signal Transduction;Sleep;Specimen;Stress;Stroke;Symptoms;Syndrome;telomere;Testing;Time;Trauma;Unhealthy Diet;Weight;Work;young adult;Youth

PROJECT_TITLE: Childhood Adversity and Biological Mechanisms of Accelerated Aging

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Clinical Research;Immunotherapy;Precision Medicine;Rheumatoid Arthritis

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE Rheumatoid arthritis is a common multisystem inflammatory condition, affecting approximately 1% of the world population. A major unmet goal in the treatment of rheumatoid arthritis is reliable clinical methodology to identify biomarkers that allow for more rational selection of therapy, so as to reduce patient morbidity, mortality, and the heavy economic burden associated with loss of function. This research will develop a patient-derived immunocompetent “Synovium-on-a-Chip” microphysiological system to accurately interrogate pathobiology and enhance precision medicine in rheumatoid arthritis.

PI_NAMEs: CHEN, WEIQIANG  (contact);WAMPLER MUSKARDIN, THERESA

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Affect;arthropathies;biological heterogeneity;Biological Models;biomarker identification;Biomedical Engineering;Biomimetics;Biophysics;Biopsy;Biopsy Specimen;Blood;Blood Circulation;Blood Vessels;CD80 gene;Cell Proliferation;cell type;Cells;Characteristics;Chronic;Clinical;clinical trial on a chip;Cues;cytokine;Data;density;Development;Devices;disease model;Disease remission;Economic Burden;effective therapy;Endothelial Cells;Engineering;Fibroblasts;Gases;Gene Expression;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Heterogeneity;Human;Hypoxia;IL8 gene;Immune;immune cell infiltrate;immune modulating agents;Immune response;Immunocompetent;immunomodulatory therapies;Immunotherapy;In Vitro;in vivo;Individual;ineffective therapies;Inflammation;Inflammatory;inflammatory milieu;insight;Interferon Type I;Interferon-beta;Interleukin-1 beta;Interleukin-6;Joints;loss of function;Macrophage;Matrix Metalloproteinases;Measurement;Measures;Methodology;Microanatomy;Microfluidics;microphysiology system;Modeling;monocyte;Morbidity - disease rate;mortality;novel;organ on a chip;Outcome;Outcome Measure;Pathogenesis;Pathogenicity;Pathologic Processes;patient stratification;Patients;Perfusion;Peripheral;personalized medicine;Physiological;Physiology;Population;precision medicine;pressure;prevent;Production;proteomic signature;Proteomics;real-time images;recruit;Research;Resistance;Rheumatoid Arthritis;Role;Sampling Studies;screening;Selection for Treatments;Signal Transduction;Structure;synergism;Synovial Cell;Synovial Membrane;System;Testing;Therapeutic Agents;therapy resistant;Tissues;TNF gene;transcriptome sequencing;transcriptomics;Treatment outcome;treatment response;tumor-immune system interactions;Vascular System;Vascularization;Work

PROJECT_TITLE: Development of a Synovium-on-a-Chip Microphysiological System to Interrogate Pathobiology and Enhance Precision Medicine in Rheumatoid Arthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (80)]


NIH_SPENDING_CATS: Digestive Diseases;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Disorders of gut brain interaction (DGBIs), like irritable bowel syndrome (IBS), functional dyspepsia, chronic diarrhea, and constipation, affect ~15% of the US population and lead to substantial chronic healthcare consumption and productivity losses, with costs estimated at $20 billion per year. A large proportion of DGBI patients have disruptions in mechanosensitivity; therefore, my laboratory's long-term goal is to elucidate the cellular and molecular mechanisms of gastrointestinal (GI) mechanosensitivity in health and DGBIs, and thus pave the way for novel targeted treatments for large cohorts of DGBI patients. We discovered a population of mechanosensitive enteroendocrine cells, which are important sensors in gut lining, and the objective of this proposal is to better understand their cellular function and roles in GI physiology, which would have substantial public health relevance since the knowledge acquired from these studies may yield novel diagnostic and therapeutic targets for DGBIs.

PI_NAMEs: BEYDER, ARTHUR  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Affect;Air;Attenuated;Award;Biological Assay;Calcium;Cell Density;Cell Line;Cell model;Cell Physiology;Cells;Cellular biology;Chemicals;Chronic;Chronic diarrhea;cohort;Constipation;Consumption;cost estimate;Cyclic AMP;Data;detection of nutrient;developmental disease;Diagnosis;Disease;disorders of gut-brain interaction;Distal;Dyspepsia;Electrophysiology (science);Endowment;Enterochromaffin Cells;Enteroendocrine Cell;Epithelial Cells;Epithelium;Esthesia;Exocytosis;experimental study;Exposure to;Functional Gastrointestinal Disorders;G-Protein-Coupled Receptors;gastrointestinal;gastrointestinal function;Gastrointestinal Motility;Gastrointestinal Physiology;Gastrointestinal tract structure;Goals;gut-brain axis;Health;Healthcare;Human;Hypersensitivity;Image;In Situ;in vivo;innovation;Intestinal Motility;Intestines;Ion Channel Gating;Irritable Bowel Syndrome;Knock-out;Knowledge;Knowledge acquisition;L Cells;Laboratories;Link;Liquid substance;Location;mechanical force;mechanical signal;Mechanical Stimulation;mechanical stimulus;Mechanics;mechanotransduction;Merkel Cells;Molecular;Motility;motility disorder;mouse model;new therapeutic target;novel;novel diagnostics;Nutrient;Oral cavity;Organoids;Outcome;Particulate;Pathway interactions;Patients;pharmacologic;Physiological;Physiology;Piezo 2 ion channel;Population;prevent;productivity loss;public health relevance;Rare Diseases;receptor;rectal mucosa;Rectum;Research;Role;selective expression;sensor;Sensory;Sensory Process;Serotonin;side effect;Signal Transduction;Signaling Molecule;Skin;Small Intestines;Solid;Stimulus;Symptoms;Tactile;Techniques;Testing;Touch sensation;Transgenic Mice;Volatile Fatty Acids;Work

PROJECT_TITLE: Mechanotransduction in gastrointestinal physiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-B (04)]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT Narrative Suicidal cell death is intrinsic to life, including single-cell microorganisms, but has been studied primarily in mammals to understand disease mechanisms and treat cancer. In contrast, mechanisms of suicidal death in microorganisms, especially pathogenic eukaryotes represents a new frontier undertaken in this study.

PI_NAMEs: HARDWICK, J. MARIE  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Agriculture;Animal Model;Animals;anti-fungal agents;Apoptosis;Bacteria;Biochemical;Biological;Biological Metamorphosis;Biological Models;cancer therapy;Candida auris;candidate identification;Cell Death;Cell Membrane Permeability;cell suicide;Cells;Cessation of life;Collection;completed suicide;Complex;conventional therapy;COVID-19;Cryptococcus neoformans;Degenerative Disorder;Destinations;Development;Developmental Process;Diagnosis;Disease;Drug resistance;Eukaryota;Evolution;extend lifespan;Fetal Development;frontier;fungus;Future;Genes;genetic approach;genome wide screen;HIV;Human;human pathogen;Immunocompromised Host;In Vitro;Individual;Infection;Inflammatory;knockout gene;Knowledge;Lead;Life;lysosome membrane;Lysosomes;Malignant Neoplasms;Mammalian Cell;Mammals;Membrane;Membrane Proteins;membrane synthesis;Microbe;microorganism;Modeling;Molds;Molecular;Molecular Mechanisms of Action;mortality;mouse model;Mycoses;Natural Immunity;neoplastic cell;novel;novel therapeutic intervention;Nutrient;offspring;Organism;pathogenic fungus;Pathogenicity;Pathologic;Pathway interactions;Permeability;Physiological;prevent;Process;Proteins;Public Health;Reporting;Research;Resistance;Role;Saccharomyces cerevisiae;Starvation;Stress;success;suicidal morbidity;targeted cancer therapy;Testing;trafficking;Tuberculosis;Vacuole;VDAC1 gene;Vesicle;Virulence;Virus;Whole Organism;Yeasts

PROJECT_TITLE: Cell death pathway leading to vacuole permeabilization

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: AUSTIN

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE The proposed research contributes to public health by investigating the neurocognitive mechanisms by which depression contributes to episodic memory impairments, and age exacerbates these impairments, in racially/ethnically diverse adults across the lifespan. Comparisons across racial/ethnic groups, in the present case Non-Hispanic Black, Mexican American, and Non-Hispanic Whites, are needed to have an accurate understanding of how depression presents across age and race/ethnicity, whether it similarly impacts memory across groups, and the race-related psychosocial factors that explain these relationships. Understanding racial/ethnic differences in depression-cognition relationships can support effective cognition, wellbeing, and independence across the lifespan, revealing who may be most sensitive to the negative effects of depression and identifying reasons why, informing future cognitive, brain stimulation, and lifestyle-based interventions.

PI_NAMEs: DOTSON, VONETTA M;DUARTE, AUDREY  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Adult;affective neuroscience;African American;Age;age difference;age effect;age group;Age of Onset;Aging;Alzheimer's Disease;Amygdaloid structure;attenuation;Black American;Black race;Blood Vessels;Brain;Chronic;chronic depression;Clinical;Clinical assessments;Cognition;Cognitive;Cognitive deficits;cognitive neuroscience;cognitive testing;Coupling;Data Set;Depressed mood;depressive symptoms;Dimensions;Disabling;Discrimination;emotion regulation;Emotional;Enrollment;Episodic memory;episodic memory impairment;ethnic difference;ethnic diversity;Ethnic Origin;Ethnic Population;ethnoracial;ethnoracial disparity;Event;Executive Dysfunction;executive function;experimental study;Failure;Functional disorder;Functional Magnetic Resonance Imaging;Future;gray matter;Health;High Prevalence;Impaired cognition;Impairment;indexing;Individual;innovation;Intervention;Knowledge;late life;life span;Life Style;lifestyle intervention;Literature;Major Depressive Disorder;Mediating;Memory;memory encoding;Memory impairment;Memory Loss;Mental Depression;Methods;Mexican;Mexican Americans;middle age;Minority Groups;Modality;Modeling;multimodal fusion;multimodal neuroimaging;negative affect;neural;Neurocognitive;neuroimaging;neuroimaging marker;neuromechanism;Neuropsychology;Neurosciences Research;Not Hispanic or Latino;novel;older adult;Outcome;Pattern;Performance;Personal Satisfaction;Persons;Prevalence;Proactive Inhibition;Proxy;psychosocial;Psychosocial Factor;Public Health;Race;racial difference;racial diversity;racial population;recruit;Religiosity;Research;Research Domain Criteria;Sampling;Severities;sleep quality;Symptoms;Testing;theories;Update;white matter;Work

PROJECT_TITLE: Executive contributions to the “double jeopardy” of depressive symptoms and age on episodic memory in racially diverse adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-N (02)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pediatric;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Project Narrative Our current U01 grant, “DIVINCI: Dissection of Influenza Vaccination and Infection for Childhood Immunity” aims to study influenza infection from birth to examine the effect of first influenza exposure and subsequent exposures on immune response using participants from three birth cohorts. The SARS-CoV-2 pandemic has caused several issues which have affected participant enrollment and incidence of influenza infections. This proposed Supplement will allow additional enrollment in Well Kiwis, support continued enrollment at UCSD, and supply testing reagents and PPE across all cohorts.

PI_NAMEs: GORDON, AUBREE L;THOMAS, PAUL G. (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Address;Affect;Birth;California;Childhood;Circulation;Clinic Visits;Clinical;cohort;Cohort Studies;Communities;cost;COVID-19 pandemic;Dissection;Enrollment;Funding;Goals;Grant;Immune response;Immunity;Incidence;Infant;Infection;infection rate;Influenza;influenza infection;Influenza vaccination;Los Angeles;meetings;New Zealand;Nicaragua;pandemic disease;Participant;participant enrollment;Pattern;reagent testing;Recording of previous events;recruit;Research;research clinical testing;respiratory;respiratory virus;Sampling;Shapes;Site;Specimen;Testing;Vaccination;Variant

PROJECT_TITLE: DIVINCI Enrollment Supplement


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Hematology;Inflammatory Bowel Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Inflammatory bowel disease (IBD) affects more than one million Americans and causes substantial morbidity and suffering, including greater susceptibility to colon cancer. MTG16 is a protein that regulates key differentiation pathways in the colon, affecting damaged colon regeneration and tumor growth in mouse IBD models. We propose to investigate the underlying mechanisms using a combination of biochemical, cellular, and animal experiments with the ultimate goal of improving IBD screening and therapeutics.

PI_NAMEs: WILLIAMS, CHRISTOPHER S. (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Affect;American;Animal Experiments;ASCL2 gene;Biochemical;Biology;Bone Marrow Transplantation;Cell Differentiation process;Cell Lineage;Cell Maintenance;cell type;Cells;Chromatin;Chromosome 16;Colitis;Colon;Colon Carcinoma;Colon Injury;Complex;Data;Defect;dextran sulfate sodium induced colitis;Diagnostic;disease model;Dysplasia;E protein;Enteroendocrine Cell;Epigenetic Process;Epithelial Cells;epithelial injury;Epithelium;Fistula;Functional disorder;gene repression;gene translocation;Genes;genetic corepressor;Genetic Transcription;Genomics;Global Change;Goals;Goblet Cells;gut inflammation;Hematopoiesis;Hematopoietic;Hematopoietic System;Homeostasis;Immune;Impairment;improved;Infection;Inflammatory Bowel Diseases;Injury;injury and repair;insight;intestinal epithelium;intestinal homeostasis;Intestines;LGR5 gene;Malabsorption Syndromes;Mediating;MLL gene;Molecular;Morbidity - disease rate;Mus;Myelogenous;Myeloid Cells;Natural regeneration;new therapeutic target;novel;Organoids;Pathogenesis;Pathway interactions;Patients;Persons;Phenotype;Play;Population;Positioning Attribute;precursor cell;Predisposition;Process;progenitor;programs;Proteins;regenerative;Regulation;Repression;Research Proposals;response to injury;Risk;Role;screening;single-cell RNA sequencing;Small Intestines;stem cell biology;stem cell differentiation;stem cell function;stem cells;Testing;Therapeutic;Therapeutic Intervention;tissue regeneration;Tissues;Transcription Elongation;transcription factor;Transcriptional Regulation;tumor growth;United States;Work;yeast two hybrid system;Yeasts

PROJECT_TITLE: MTGs in Intestinal Biology and Injury Responses

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative While fibroblast activation protein-α (FAP) has emerged as a potential target for pancreatic ductal adenocarcinoma (PDAC) imaging using small molecule radiopharmaceuticals, the translation of FAP-targeted radionuclide therapy (FAP-TRT) has, thus far, failed. The proposed studies aim to develop, optimize and characterize a novel class of FAP-targeting agents (FAPTAs) based on lysosomal adduct formation and trapping to enhance tumor residualization and evaluate their efficacy in novel models recapitulating PDAC tumor microenvironment and heterogeneous FAP expression observed in human disease. This proposal will result in a novel class of FAPTAs that can deliver clinically relevant radionuclides (177Lu & 225Ac) to image and treat primary and metastatic PDAC.

PI_NAMEs: GARRISON, JERED C (contact);JAIN, MANEESH

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: adduct;Affinity;analog;Autoradiography;Biodistribution;Biological;Biological Assay;Biology;Biotin;cancer diagnosis;Cancer Etiology;Caspase;Cells;Cessation of life;Chemicals;Chemotherapy and/or radiation;Clinical;clinical imaging;clinical translation;Clinical Trials;clinically relevant;comparative efficacy;Confocal Microscopy;Data;design;Disease;Dose;dosimetry;Drug or chemical Tissue Distribution;Electrophoresis;External Beam Radiation Therapy;fibroblast activation protein alpha;Fibroblasts;Fluorescence Microscopy;Future;Goals;Health;Heterogeneity;Human;human disease;Image;imaging study;implantation;improved;In Vitro;in vitro Assay;in vivo;Investigation;Investigational Drugs;Label;Laboratories;liquid chromatography mass spectrometry;Lysosomes;Malignant neoplasm of pancreas;Malignant Neoplasms;Maximum Tolerated Dose;Modeling;Molecular Weight;mouse model;neoplastic cell;New Drug Approvals;Normal tissue morphology;novel;novel therapeutics;Operative Surgical Procedures;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;Pathway interactions;Patient-Focused Outcomes;Patients;Performance;Pre-Clinical Model;Radiation Dose Unit;Radioisotopes;Radionuclide therapy;Radiopharmaceuticals;Refractory;Role;Safety;selective expression;small molecule;Streptavidin;Structure;Survival Rate;targeted agent;targeted treatment;Testing;theranostics;Therapeutic;therapeutic evaluation;Time;Tissues;Toxic effect;trafficking;translational therapeutics;Translations;Treatment Efficacy;Treatment Protocols;treatment response;tumor;tumor microenvironment;uptake

PROJECT_TITLE: Lysosome Trapped FAP-Targeted Theranostics for Pancreatic Cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Precision Medicine

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: PROJECT NARRATIVE Although over 95% of human genes have alternative transcript isoforms, most cancer studies largely ignore the impact of isoform-specific function. In this study, we will identify and functionally characterize a large set of cancer gene-isoform variants with and without somatic mutation. This project will provide a new framework for identification and characterization of cancer-associated isoforms, their functional impact on cancer, and their contribution to drug sensitivity and resistance.

PI_NAMEs: BERGER, ALICE ;BROOKS, ANGELA NORIE (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Affect;Alleles;anti-cancer research;Automobile Driving;Biological;Biological Assay;Biology;biomarker driven;Biopsy;BRAF gene;Cancer Biology;cancer biomarkers;cancer care;Cancer cell line;Cancer Detection;cancer genomics;cancer therapy;Cell Line;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Collaborations;Communities;Cytogenetics;Data;Development;Dideoxy Chain Termination DNA Sequencing;Drug resistance;drug sensitivity;Epidermal Growth Factor Receptor;Event;exon skipping;Exons;Explosion;functional genomics;Gene Expression;gene function;Gene Fusion;Gene Mutation;Genes;Genetic Engineering;genome annotation;genomic data;Genotype;Heterogeneity;Human;In Vitro;in vivo;inhibitor;innovation;insight;kinase inhibitor;KRAS2 gene;Length;Link;Lung Adenocarcinoma;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mass Spectrum Analysis;MEKs;Messenger RNA;Methodology;Methods;Monitor;mutant;Mutate;Mutation;next generation sequencing;Oncogenes;Oncogenic;Open Reading Frames;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;Peptides;personalized medicine;Phase;Phenotype;Philadelphia Chromosome;Positioning Attribute;precision medicine;precision oncology;preclinical trial;prime editing;prospective;Protein Isoforms;Publications;Ras Inhibitor;Resistance;resistance mechanism;Resources;response;RNA;RNA Processing;RNA Splicing;Role;Sampling;Somatic Mutation;Specimen;targeted treatment;technological innovation;Technology;Testing;The Cancer Genome Atlas;therapy resistant;tool;Transcript;transcriptome;transcriptome sequencing;tumor;tumorigenesis;Variant;Work;Xenograft Model;Xenograft Model Antitumor Assays

PROJECT_TITLE: Computational and functional discovery of isoforms driving cancer and drug resistance

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Following a myocardial infarction, an intense inflammatory response occurs whose duration and magnitude are modulated by CD4+CD25+Foxp3+ regulatory T cells (Tregs) that express CD39, an ectonucleotidase that degrades proinflammatory ATP and ADP. While the level of CD39 expression is genetically controlled in human Tregs by the genotype at specific single nucleotide polymorphisms, no studies have examined the impact of genetically determined Treg CD39 expression on inflammatory resolution and healing following myocardial infarction. In response to NOT-ES-20-018 Notice of Special interest: Promoting Fundamental and Applied Research in Inflammation Resolution,” we propose to determine how genetically determined differences in CD39 activity on Tregs impact the inflammatory resolution following myocardial infarction.

PI_NAMEs: GUMINA, RICHARD J (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Ablation;Acute;Address;Affect;Applied Research;Area;Biological;Biological Markers;Biological Models;Biometry;Cardiac;Cardiovascular Diseases;Cardiovascular system;Cell Compartmentation;Cell Physiology;Cell Separation;Cells;Cessation of life;Chronic;Clinical;clinical practice;Clinical Research;coronary fibrosis;Data;diagnostic strategy;Disease;ecto-nucleotidase;effector T cell;EFRAC;Endothelial Cells;Equilibrium;Experimental Models;experimental study;extracellular;Fibrosis;FOXP3 gene;Functional disorder;functional genomics;fundamental research;Genes;Genetic;Genetic Determinism;Genetic Polymorphism;Genotype;Goals;healing;Heart failure;Homeostasis;Human;Human Biology;Human Genetics;IL2RA gene;Immune;immune checkpoint;Immune response;immunopathology;Impairment;Infarction;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;interest;Knock-out;Link;Macrophage;Modeling;Molecular;monocyte;mouse model;Mus;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocarditis;National Heart, Lung, and Blood Institute;new therapeutic target;novel;novel diagnostics;Outcome;Outcome Study;Pathway interactions;Patients;Persons;Phenotype;promoter;Publications;Publishing;Recovery;Regulation;Regulatory T-Lymphocyte;Resolution;response;Role;Signal Pathway;Single Nucleotide Polymorphism;SNP genotyping;T memory cell;T-Lymphocyte;Testing;Therapeutic Intervention;Translations;treatment strategy;United States;Work

PROJECT_TITLE: Genetic modulation of inflammation following myocardial infarction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-C (02)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: NARRATIVE Meiosis is the cellular process that gives rise to haploid gametes (sperm and oocytes) for reproduction and must be tightly regulated to avoid errors that could prevent fertility or lead to developmental defects in offspring. This proposal seeks to understand how a key DNA damage response pathway enforces quality control during both male and female meiosis. Cutting-edge molecular techniques and innovative mouse models will be used to precisely and comprehensively define key molecular events underlying successful gamete production, with important implications for infertility and the origins of birth defects.

PI_NAMEs: COHEN, PAULA ELAINE;SMOLKA, MARCUS ;WEISS, ROBERT S (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Aneuploidy;Apical;Apoptosis;ATAC-seq;Automobile Driving;autosome;BRCT Domain;Cell Cycle Progression;Cell division;Cell Nucleus;Cell Physiology;Cells;Chemicals;Chromatin;Chromosome Pairing;Chromosome Segregation;Chromosomes;Closure by clamp;Complex;Congenital Abnormality;Data;Defect;Development;Disease;DNA Damage;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Ensure;Environment;Event;Female;Fertility;Funding;Gamma-H2AX;Gene Expression;Gene Silencing;Genetic;genetic approach;Genetic Nondisjunction;Genetic Recombination;Genetic Transcription;Genome;genome-wide;Genomic approach;genomic tools;Genomics;Germ Cells;Haploidy;helicase;Histones;Homologous Gene;Hour;Housing;Human;Infertility;inhibitor;innovation;insight;Klinefelter's Syndrome;Knowledge;Laboratory mice;Lead;Link;Live Birth;Maintenance;male;Mammals;Mediating;Meiosis;Meiotic Prophase I;Membrane;Modeling;Molecular;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;novel;offspring;Oocytes;Organism;Pathway interactions;pharmacologic;Phosphoric Monoester Hydrolases;Phosphotransferases;Play;Polymerase;Positioning Attribute;prevent;Process;Production;protein protein interaction;Proteomics;Pseudoautosomal Region;Quality Control;RAD9A gene;Regulation;repaired;Reproduction;Resolution;response;RNA;Role;Running;scaffold;sex;Sex Chromosomes;Sexual Reproduction;Signal Transduction;single-cell RNA sequencing;sperm cell;Spermatocytes;Spontaneous abortion;Synapses;Synaptonemal Complex;Techniques;Tertiary Protein Structure;Testing;Time;TOPBP1 Gene;Variant;Y Chromosome

PROJECT_TITLE: Coordination of Atr Signaling for Genetic Quality Control, Silencing, and DNA Repair during Meiosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-C (02)]


NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: TITLE: Programs for generating inhibitory interneuron diversity and connectivity NARRATIVE: Inhibitory interneurons modulate the output of diverse neural circuits, and their dysfunction is linked to a growing number of neuropsychiatric and neurodegenerative disorders. Here we propose to define key functionally relevant programs for producing interneurons and test their functional capacity using deep phenotyping. This will enable new means to identify and implement inhibitory neuron-based therapeutics.

PI_NAMEs: AU, EDMUND ;BALDWIN, KRISTIN KAY (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Acceleration;Activities of Daily Living;Alzheimer's Disease;autism spectrum disorder;Bar Codes;base;Biological Assay;Brain;Cell Therapy;cell type;Cells;Cellular Morphology;Classification Scheme;Code;Collaborations;combinatorial;Complex;Data;Development;Disease;disease model;disorder risk;Dissociation;Doxycycline;Endowment;Epigenetic Process;Epilepsy;Fibroblasts;Functional disorder;gain of function;gene regulatory network;Generations;Genetic;Genetic Risk;Genetic study;Genetic Transcription;Genomics;Goals;high throughput screening;Human;Image;improved;In Vitro;in vivo;Individual;Induced Neurons;induced pluripotent stem cell;inhibitory neuron;intercalation;Interdisciplinary Study;Interneuron function;Interneurons;Label;Libraries;Link;Logic;machine learning method;Methods;migration;Migration Assay;Molecular Analysis;Morphology;Motility;multimodality;Mus;Nerve Degeneration;neural circuit;Neurodegenerative Disorders;Neurons;neuropsychiatric disorder;novel;Outcome;Output;Pattern;Periodicity;Phenotype;Population;Population Heterogeneity;Positioning Attribute;Production;programs;repaired;Reproducibility;Resources;Schizophrenia;screening;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Specificity;Synapses;synaptogenesis;Technology;Test Result;Testing;Therapeutic;tool;transcription factor;transcriptome;transcriptomics;transplant model;Transplantation

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

PHR: Project Narrative The 21st in the series of Hilton Head Workshops (HH2024) on the science and technology of Solid-State Sensors, Actuators, and Microsystems will take place June 2 - 6, 2024 at the Sonesta Resort on Hilton Head Island, SC. Here we propose to utilize the support from the NIH as travel awards for student trainees, post- doctoral fellows, and junior faculty from various backgrounds to attend this premier academic workshop and increase the diversity and inclusion of our field.

PI_NAMEs: LEE, HYOWON  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Academia;Achievement;Address;Anniversary;Award;bioimaging;Biology;Biomedical Engineering;biomedical imaging;Biomedical Technology;Biosensor;career;Chemicals;Chemistry;clinical diagnostics;Collaborations;commercialization;Communities;Devices;Diagnosis;Diagnostic;Discipline;diversity and inclusion;Drug Delivery Systems;Educational workshop;Electrical Engineering;Engineering;Ensure;Environment;Event;Faculty;Fostering;Future;global health;Government;Growth;Head;Health;Healthcare;Human;Implant;implantable device;Implantable Infusion Pumps;improved;Individual;Industry;innovation;interdisciplinary collaboration;Interdisciplinary Study;Island;Knowledge;manufacturing technology;materials science;Medicine;Mentors;Microfabrication;microsystems;Mission;multidisciplinary;nano;nanoscale;pandemic disease;Participant;Patient Care;Physics;Postdoctoral Fellow;posters;practical application;Preparation;Prevention;programs;Regenerative Medicine;Research;Research Personnel;Resort;Science;sensor;sensor technology;Series;Societies;solid state;Students;success;symposium;System;systems research;Technology;Translational Research;Travel;Underrepresented Populations;United States National Institutes of Health

PROJECT_TITLE: Hilton Head Solid State Sensors, Actuators and Microsystems Workshop

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (J1)]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative This project aims to examine the relationship between functional cerebellar atypicalities and sensory over- responsivity (SOR) in autism spectrum disorder (ASD). Findings from this study will provide new insight into the involvement of the cerebellum in ASD symptomatology and help to characterize the complex neural mechanisms underlying SOR. Results derived from this research will inform future behavioral and psychopharmacological treatment strategies to target sensory symptoms in ASD youth.

PI_NAMEs: CAKAR, MELIS E (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Acoustic Stimulation;adolescent with autism spectrum disorder;Age;Amygdaloid structure;Anatomy;Attention;autism spectrum disorder;autism symptoms;autistic children;Behavioral;brain circuitry;Brain region;California;career;Cellular Structures;Cerebellum;Cerebrum;Child;Clothing;Cognitive;Committee Members;Complex;daily functioning;Development;effective intervention;emotion regulation;Emotional;Ensure;Evaluation;Evidence based treatment;experience;Fellowship;Financial Support;flexibility;Functional Magnetic Resonance Imaging;Future;Goals;graduate student;habituation;Impairment;improved;Individual;Individual Differences;individuals with autism spectrum disorder;insight;Intervention;Knowledge;Life;Link;Lobule;Los Angeles;Loudness;Measures;Medial;Mental disorders;Mentorship;Methods;Modeling;Motor;National Institute of Mental Health;neural;neurodevelopment;neuroimaging;neuromechanism;Neurosciences;Noise;Parents;Participant;Play;Prefrontal Cortex;psychopharmacologic;Quality of life;repetitive behavior;Reporting;Research;Research Infrastructure;Research Personnel;Resources;response;Rest;Role;Sensory;sensory cortex;Sensory Disorders;sensory mechanism;sensory stimulus;Severities;sex;skills;social;social deficits;Source;Strategic Planning;symptomatology;Symptoms;tactile stimulation;Thalamic structure;theories;Therapeutic;Time;Training;treatment strategy;Universities;Work;Youth

PROJECT_TITLE: The Involvement of the Cerebellum in Sensory Over-Responsivity in Autism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Kidney Disease;Neurosciences;Nutrition;Rare Diseases;Regenerative Medicine

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Our sense of taste is mediated by taste buds on the tongue surface, and we use this sensory system to allow us to choose what to eat and what to avoid. Taste bud cells, like skin, continually renew throughout life, making taste prone to damage cancer therapies. Here we use mice to better understand how a particular chemotherapy used to treat kidney cancer causes troubling taste dysfunction for patients.

PI_NAMEs: BARLOW, LINDA A (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Adult;Affect;Antineoplastic Agents;Attention;Behavioral Assay;Body Weight decreased;Cancer Etiology;Cancer Patient;cancer therapy;Cell Differentiation process;Cell Survival;Cells;chemotherapy;Clinical;Data;Data Set;Dental Hygiene;Desire for food;Diet Modification;Dose;Drug Targeting;Drug usage;Dysgeusia;Eating;Epithelium;Exclusion;experience;Functional disorder;Future;Genes;Hair;Homeostasis;Hypopigmentation;Impairment;In Vitro;in vivo;Interruption;Intervention;Investigation;KITLG gene;Letters;Life;Ligands;Malignant Neoplasms;Malnutrition;Mediating;Melanins;Mental Depression;Metastatic Renal Cell Cancer;Modality;Molecular;Molecular Genetics;Mus;Natural regeneration;Nerve;novel;Organoids;paracrine;Patients;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;Prevalence;Production;Proliferating;Proteins;Publishing;Quality of life;receptor;Receptor Cell;Receptor Protein-Tyrosine Kinases;Renal Carcinoma;Reporting;Role;sensory system;side effect;Signal Transduction;Skin;Sodium Chloride;Stem Cell Factor;stem cells;Surface;sweet taste perception;Taste Bud Cell;Taste Buds;Taste Perception;taste system;Testing;Therapeutic Uses;Tongue;transcriptomic profiling;trend;tumor;Tyrosine Kinase Inhibitor;Tyrosine Kinase Receptor Inhibition;Vascular Endothelial Growth Factor Receptor-1;Vascularization;Western Blotting;Work

PROJECT_TITLE: The role of Kit signaling in taste bud regeneration

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Contraception/Reproduction;Infertility

ORG_CITY: NEW HAVEN

ORG_DEPT: PHYSIOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The primary causes of male infertility are defects in sperm motility and capacitation, which require properly functioning Ca2+ signaling. The proposed research is relevant to public health because it aims to provide molecular insights into the sperm Ca2+ channel CatSper and the CatSper-organized signaling nanodomains, whose integrity is required for sperm energy metabolism, thus sperm motility and male fertility. The proposed research is relevant to the NIH’s mission because it will improve our understanding of sperm physiology and male fertility, which may enable the development of more effective strategies for the diagnosis, treatment, and prevention of conditions that affect male fertility, with the ultimate goal of promoting a better quality of life for all individuals.

PI_NAMEs: CHUNG, JEAN-JU LUCIA (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Affect;Animal Model;assisted reproduction;Biochemical;Calcium Signaling;CatSper;comparative;Complex;contraceptive target;Cryo-electron tomography;Defect;Development;Diagnosis;Dominant-Negative Mutation;Electrophysiology (science);Energy Metabolism;Extracellular Domain;female reproductive tract;Fertility;Fertilization;Flagella;Funding;Genetic;GLUT-3 protein;Glycolysis;Goals;Homeostasis;Human;Image;Imaging Techniques;improved;In Situ;Individual;insight;Investments;Ions;Knockout Mice;Knowledge;loss of function;male fertility;Male Infertility;Membrane;Metabolic;Metabolic Pathway;migration;Mission;Mitochondria;Molecular;molecular imaging;Molecular Profiling;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Mutant Strains Mice;nano;nanoscale;novel;novel strategies;Nutrient;Oxidative Phosphorylation;Pathway interactions;Peritoneal;phosphoproteomics;Phosphorylation;Physiological;Physiology;prevent;Prevention;Productivity;programs;Proteomics;Public Health;Quality of life;Regulation;Regulation of Proteolysis;Reporting;Research;Resolution;Role;Scanning Electron Microscopy;Signal Pathway;Signal Transduction;Site;Sperm Capacitation;sperm cell;Sperm Motility;sperm viability;Structure;Substrate Specificity;superresolution imaging;Surface;System;Time;trafficking;Ubiquitin;ubiquitin-protein ligase;United States National Institutes of Health;Work

PROJECT_TITLE: CatSper regulation of sperm physiology and fertility


NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: Huntington’s disease (HD) is a fatal, dominantly inherited neurodegenerative disorder that primarily affects neurons in the striatum and cortex. Our work has identified striatal developmental impairments in HD and transcriptional pathways that are amenable to disease-modifying interventions. Our work will advance the field by furthering the understanding of abnormal HD striatal developmental molecular mechanisms and identify potential interventions early in the pre-manifest phase of the illness.

PI_NAMEs: ELLERBY, LISA M (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Affect;Alleles;Aminobutyric Acids;Award;Basal Ganglia Diseases;Bioinformatics;Brain;cell type;Cells;Cerulenin;Chorea;Corpus striatum structure;Data Set;Development;Disease;disease phenotype;Early Intervention;Emotions;Enhancers;excitotoxicity;executive function;Exhibits;Failure;Functional disorder;functional restoration;Gene Expression;Gene Family;Genes;Genetic Transcription;Growth;Histone Deacetylase;Human;human data;Huntington Disease;Huntington gene;Impairment;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inherited;Injections;Intervention;knock-down;Life;Link;Maintenance;Modeling;Molecular;motor control;motor learning;mouse model;Mus;Nerve Degeneration;nerve stem cell;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuronal Differentiation;Neurons;novel;NR4A1 gene;Organoids;Output;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phenotype;polyglutamine;postnatal;Predisposition;prevent;Process;Proteins;Publications;putamen;Regulation;Reporter;Role;Signal Pathway;single-cell RNA sequencing;STAT1 gene;stem cells;striosome;Structure;Symptoms;Testing;Therapeutic;therapeutic target;transcription factor;transcriptome;Work

PROJECT_TITLE: Identifying Factors Regulating Medium Spiny Neuron Differentiation or Maintenance as Therapeutic Targets for Huntington's Disease using Induced Pluripotent Stem Cells

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE  This project will advance fundamental knowledge about the causes and consequences of changes in social, demographic, economic, and health characteristics of the older population and will support research on the effects of public policies, social institutions, and environmental conditions on the health, well-being, and functioning of individuals over their life-course.

PI_NAMEs: BAILEY, MARTHA JANE (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, JOHN

PROJECT_TERMS: Address;Age;Aging;aging related;Alabama;Birth;Black race;California;Cause of Death;Censuses;Cessation of life;Characteristics;Child;Code;Cognitive;cohort;cost effective;Data;data centers;data infrastructure;data quality;Data Set;Databases;Death Certificates;Death Records;Documentation;Economics;Education;Electronics;Family;Generations;Geography;Health;Health and Retirement Study;health data;health determinants;Heterogeneity;Household;improved;indexing;Individual;Industrialization;Infant;Infrastructure;Institution;intergenerational;Investments;Kentucky;Knowledge;Life;Life Cycle Stages;Link;Longevity;Longitudinal Studies;machine learning model;Marriage;Massachusetts;Measures;Mediating;Minnesota;Minority;Mission;mortality;North Carolina;Ohio;Older Population;open source;panel study of income dynamics;Personal Satisfaction;Persons;Policies;Policy Making;Politics;Population;Population Process;population survey;Public Health;Public Hospitals;Public Policy;Records;repository;Research;Research Infrastructure;Research Personnel;Research Support;Resources;Respondent;Role;Sample Size;Sampling;Sampling Studies;social;Social Processes;Social Security;sociodemographics;Subgroup;Surveys;Texas;Training;Universities;Urbanization;Vermont;War;Woman;Work;World War I;World War II

PROJECT_TITLE: LIFE-M 2.0: Data Infrastructure for Understanding the Longitudinal and Intergenerational Determinants of Health and Aging

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Type 2 diabetes (T2D) is a chronic cell degenerative disease characterized by hyperglycemia due to progressive destruction of pancreatic β-cells due to these cells having to counter upstream insulin resistance (most often in obese states). The high secretory burden of these insulin-producing professional secretory cells predisposes them to high levels of endoplasmic reticulum (ER) stress, and recent work from our laboratories has shown that the activation of ER stress response pathways such as the unfolded protein response—UPR—may be an initial causal event in the development of T2D. In this collaborative grant we capitalize on our complementary expertise of the investigators to pharmacologically target the UPR by advancing new kinase inhibitors called KIRAs as new disease-modifying approaches for T2D.

PI_NAMEs: MALY, DUSTIN J;PAPA, FEROZ R (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Adipose tissue;Anti-diabetic Drugs;Apoptosis;Autoimmunity;Beta Cell;biological adaptation to stress;Biological Availability;Cell Differentiation process;Cells;Cessation of life;Chaperone Gene;chemical genetics;Chronic;Clinic;clinical candidate;Degenerative Disorder;design;Development;Diabetes Mellitus;diabetogenic;diet-induced obesity;Dimerization;Disease;Drug Kinetics;efficacy study;Endoplasmic Reticulum;endoplasmic reticulum stress;Endoribonucleases;Event;Fatty acid glycerol esters;Future;Gene Expression Profiling;Generations;Genetic Transcription;glucose uptake;Goals;Grant;High Fat Diet;Homo;Human;human model;humanized mouse;Hyperactivity;Hyperglycemia;Immunodeficient Mouse;Impaired fasting glycaemia;Implant;Inflammation;inhibitor;Insulin;Insulin Resistance;insulin secretion;Insulin-Dependent Diabetes Mellitus;Integral Membrane Protein;islet;Islets of Langerhans;kinase inhibitor;Laboratories;Lead;Leptin deficiency;Liver;Messenger RNA;Metabolic;Modeling;Modification;Molecular Chaperones;mouse model;Mus;mutant;nanomolar;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;Obesity;Oral;Organ;Output;Pathway interactions;Patients;Peripheral;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phosphotransferases;Pre-Clinical Model;premature;prevent;Production;programs;Proinsulin;Proteins;Pyrazines;pyridine;Pyrimidine;Quinazolines;Reagent;Research;Research Personnel;response;Ribonucleases;RNA Splicing;Safety;safety study;scaffold;Secretory Cell;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;Stress;Structure;Structure of beta Cell of islet;System;Testing;Thiazoles;Tissues;transcription factor;translational model;Work;XBP1 gene

PROJECT_TITLE: Disease-modifying drugs for T2D through targeting the Unfolded Protein Response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease;Substance Misuse

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Public Health Statement/Project Narrative Alcoholic liver disease (ALD) poses a significant threat to public health, accounting for approximately a half million death annually worldwide and the disease burden is projected to increase. This proposal is aimed at defining the molecular mechanism underlying the development of alcoholic fatty liver (AFL), the initial stage of ALD. The insights obtained through this study will reveal novel targets for the development of therapeutics that mitigate the disease burden of ALD.

PI_NAMEs: SAITO, TAKESHI  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Abstinence;Accounting;Advanced Development;Alcohol abuse;Alcoholic Fatty Liver;Alcoholic Liver Cirrhosis;Alcoholic Liver Diseases;Alcoholic steatohepatitis;Benign;Biochemical;Biological;biological adaptation to stress;Biological Models;burden of illness;cell injury;Cells;Cessation of life;chronic liver disease;Cirrhosis;Clinical;cytotoxicity;design;Development;Disease;Disease Progression;effective intervention;Enzymes;Ethanol;Ethanol Metabolism;Failure;Foundations;Functional disorder;Future;gene function;Genes;genetic approach;Genetic Transcription;Goals;Hepatocyte;Histologic;Histopathology;Homeostasis;Human;human disease;Impairment;improved;In Vitro;in vivo Model;Inflammation;insight;Intervention;Investigation;Lipids;Liver;liver development;Liver diseases;long term abstinence;Maintenance;Maps;Medical;Messenger RNA;Metabolic stress;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;mRNA sequencing;mTOR Signaling Pathway;multiple omics;new therapeutic target;novel;novel therapeutic intervention;Outcome;Pathogenesis;Pattern;Physiological;Poly(ADP-ribose) Polymerases;polysome profiling;Process;Production;Protein Isoforms;Proteins;Proteome;Proteomics;Public Health;Regulation;Resolution;response;ribosome profiling;Ribosomes;Role;Specimen;Study models;Substance abuse problem;System;therapeutic development;therapeutic target;Toxic effect;transcriptome;Translating;translational study;Translations;translatome

PROJECT_TITLE: Hepatocyte Metabolic Stress Response to Alcoholic Fatty Liver

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Maternal Health;Pediatric;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE This project will advance fundamental knowledge about the measurement and determinants of abortion and the possible consequences of Dobbs in the United States. In addition, this research will contribute to a deeper understanding of maternal and reproductive health and advance research on the effects of public policies, social institutions, and environmental conditions in determining maternal and reproductive health.

PI_NAMEs: BAILEY, MARTHA JANE (contact);LANG, VANESSA WANNER;LINDBERG, LAURA D

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;adolescent health;Age;Attitude;Behavior;Biological;birth control;Black race;Categories;Centers for Disease Control and Prevention (U.S.);Child;child bearing;Chills;Coercion;Contraceptive Agents;cost effective;court;Data;Data Collection;data resource;Data Sources;Domestic Violence;Ethnic Origin;Evaluation Studies;Exploratory/Developmental Grant;Face;Failure;Family;Female;follow-up;Future;Generations;Gestational Age;Goals;Grant;Growth;Health;health organization;Hispanic;Household;improved;Incidence;Income;Individual;Infertility;innovation;Institution;Knowledge;Latina;Longitudinal Surveys;Maternal and Child Health;Maternal Health;Measurement;Measures;Medical Records;Mental Health;Methods;Michigan;Mothers;National Longitudinal Survey of Youth;Participant;Patients;physical conditioning;Policies;Population;Poverty;Pregnancy;Process;Provider;Public Policy;Publishing;Race;Reporting;Reproductive Health;Research;Research Personnel;research study;Respondent;response;Sampling Studies;social;statistics;Subgroup;substance use;Surveys;Time;United States;United States Supreme Court;Violence;Voting;Vulnerable Populations;Woman;Women's Health

PROJECT_TITLE: Leveraging Medical Records to Understand the Underreporting of Abortion Before and After Dobbs

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]