NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE While the Pap test has been routinely performed for over 50 years to screen women for cervical cancer, there is currently no reliable method to screen women for ovarian cancer. Our preliminary data suggest that proteins shed by ovarian cancer cells are present in the residual Pap test fixative and on cervical swabs, and that these proteins can be quantified by targeted mass spectrometry-based proteomic techniques. This study lays the groundwork for incorporating the routine Pap test or a self-administered cervical swab into a clinical assay that can be used to identify 21,000 new cases of ovarian cancer annually in the United States, thereby saving the lives of women by earlier detection.

PI_NAMEs: SKUBITZ, AMY PATRICE (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Abnormal Cell;Alcohols;Benign;Bioinformatics;Biological Assay;Biological Markers;biomarker discovery;cancer biomarkers;cancer cell;cancer diagnosis;Cancer Etiology;candidate marker;Cells;Cervical;Cervical Cancer Screening;Clinic;Clinical;cohort;Collecting Cell;Collection;cost effective;Coupled;Data;Data Analyses;Detection;detection assay;Development;Diagnostic;Diagnostic Reagent Kits;differential expression;Disease;Early Diagnosis;experimental study;fimbria;Fixatives;Future;General Population;Goals;Gynecologic;Gynecologic Surgical Procedures;Hand;high risk population;Home;home test;HPV screening;improved;Institutional Review Boards;Label;Lesion;liquid biopsy;Liquid substance;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of ovary;Mammalian Oviducts;Mass Spectrum Analysis;Measurement;Methods;Monitor;Pap smear;Patients;Peptides;Performance;Physicians;Positioning Attribute;protein biomarkers;Proteins;Proteomics;Reaction;reproductive tract;Residual state;Resources;sample collection;Sampling;screening;Screening for Ovarian Cancer;Screening procedure;Self Administration;Sensitivity and Specificity;Serous;Site;Source;Survival Rate;Swab;Techniques;Testing;Translating;tumor;Tumor Tissue;United States;Uterus;Vagina;Woman;women's diagnosis;Women's mortality

PROJECT_TITLE: A paradigm shift for ovarian cancer biomarkers: Utilizing routine Pap tests as liquid biopsies for the development of targeted mass spectrometry-based proteomic assays for early detection

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Autosomal dominant polycystic kidney disease (PKD) is a common inherited disorder accounting for ~5% of the dialysis and kidney transplant population in the US. This grant seeks to determine new genetic causes of this disease, develop cellular and whole animal systems to determine the significance of variants found in genes causing ADPKD, explore treatment options that take advantage of increased understanding of the ADPKD mutational mechanism, and determine the importance of genetic events within cystic cells to disease development. These studies will result in a better understanding of the causes of ADPKD and improve diagnostics and treatment options.

PI_NAMEs: HARRIS, PETER C. (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Accounting;Address;Alleles;Animal Model;Animals;Autosomal Dominant Polycystic Kidney;Biological Assay;Biological Models;Cells;Cellular Assay;Cilia;Classification;Clinic;Clinical Data;clinical diagnosis;Complex;Cyst;Cystic kidney;Data;Defect;Development;Diagnostic;Dialysis patients;Dialysis procedure;Disease;disease phenotype;DNA sequencing;dosage;Etiology;Evaluation;Event;Evolution;exome sequencing;FDA approved;Genes;Genetic;genetic disorder diagnosis;Genotype;Goals;Grant;Guidelines;Hereditary Disease;improved;In Vitro;in vitro testing;in vivo;in vivo Model;Individual;insight;Kidney Diseases;Kidney Failure;Kidney Transplantation;Location;Measures;membrane biogenesis;Mendelian disorder;Methods;Minor;Modeling;Molecular Chaperones;Mus;Mutation;Nature;new therapeutic target;next generation sequencing;novel;novel therapeutics;Pathogenesis;Pathogenicity;patient population;Patients;Penetrance;Pharmaceutical Preparations;Phenotype;PKD2 protein;Play;polycystic kidney disease 1 protein;Population;Preclinical Testing;Proprotein Convertase 1;Proprotein Convertase 2;protein misfolding;Protein Secretion;protein transport;Proteins;rare variant;Role;screening;Sequence Analysis;side effect;Signal Transduction;single cell sequencing;Somatic Mutation;System;Testing;trafficking;Transplant Recipients;treatment strategy;Variant;variant of unknown significance;virulence gene

PROJECT_TITLE: ADPKD: Disease Spectrum & Genotype-Phenotype Correlations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(05)]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: COLUMBIA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE While the Zika virus (ZIKV) infection has been linked to congenital glaucoma, the molecular mechanisms of the disease are still unknown. Thus, elucidation of pathological mechanisms underlying TM dysfunction in ZIKV- induced glaucoma is of paramount importance to identify key pathways that can be targeted to develop new therapeutics for the prevention of infectious glaucoma. This study will use human primary trabecular meshwork cells (HTMC) and mouse neonate pups and congenital infection models to investigate the role of ZIKV infection in the pathobiology of glaucoma.

PI_NAMEs: SINGH, PAWAN KUMAR  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acids;Affect;age-related disease;Animal Model;Anterior;anterior chamber;Anterior eyeball segment structure;Anti-viral Response;Antibodies;Antibody-Dependent Enhancement;aqueous;Atrophic;attenuation;Autophagocytosis;Axonal Transport;biological adaptation to stress;C57BL/6 Mouse;Case Study;Cell Death;Cell model;Cells;Cessation of life;Choroid;Clinical;combat;congenital infection;congenital zika syndrome;Country;Development;Disease;endoplasmic reticulum stress;Epidemic;epidemic virus;Exhibits;Experimental Models;Exposure to;Extracellular Matrix;Eye;FDA approved;Flavivirus;Flavivirus Infections;Functional disorder;Future;Genetic;Glaucoma;global health;Goals;Human;Hydrophthalmos;Hydroxychloroquine;Hypoxia;IFNAR1 gene;In Vitro;in vivo;in vivo Model;Infant;Infection;inhibition of autophagy;inhibitor;interferon alpha receptor;intraperitoneal;Knock-out;Laboratories;Link;macula;Mediating;Microcephaly;Modeling;Molecular;Mothers;mouse model;Mus;Neonatal;neonate;nerve damage;Newborn Infant;novel;novel therapeutics;offspring;Optic Nerve;Outcome Study;Pathogenesis;pathogenic virus;Pathologic;Pathology;Pathway interactions;permissiveness;Persons;Pharmaceutical Preparations;pharmacologic;Physiologic Intraocular Pressure;Pigmentation physiologic function;Posterior eyeball segment structure;Pregnancy;prevent;Prevention;primary outcome;prognostic;Publishing;pup;Reporting;Retina;retina blood vessel structure;Retinal Ganglion Cells;Role;Sirolimus;Stimulus;Testing;Therapeutic;therapeutic target;Time;Tissues;tool;Trabecular meshwork structure;transcriptome sequencing;transcriptomics;transmission process;Treatment Efficacy;type I interferon receptor;Virus Replication;Visual;Zika Virus;ZIKV infection

PROJECT_TITLE: Role of Zika virus (ZIKV) infection in glaucoma pathobiology


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative We focus on understanding fundamental mechanisms governing immune modulation and progression of disseminated tumor cells at the metastatic sites, both of which carry immense clinical relevance in treating metastatic disease in women with triple negative breast cancer, for which there currently is no cure. Moreover, the proposed studies focusing on tumor-derived exosomes carry a high translational potential in the development of liquid biopsy-based biomarkers for noninvasive detection, and discovery of new targets for immunotherapy and prevention of metastasis.

PI_NAMEs: GUO, WEI ;RADHAKRISHNAN, RAVI  (contact);WEAVER, VALERIE MARIE

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Address;Adhesions;Affect;Aggressive behavior;anti-cancer research;Biological Markers;Biology;Biomedical Engineering;biophysical model;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Cancer Biology;cancer cell;Cancer Patient;cell cortex;Cell Culture Techniques;cell growth;Cells;Cellular biology;Cessation of life;Clinical;Clinical Pathology;clinically relevant;Collaborations;Cytoskeleton;Data;Deposition;Desmoplastic;Development;Devices;Disease;Disseminated Malignant Neoplasm;Drug Kinetics;Exhibits;exosome;experimental study;Extracellular Matrix;Fostering;Foundations;Future;Genetically Engineered Mouse;Immune checkpoint inhibitor;Immune Evasion;Immune system;Immunity;Immunologic Surveillance;Immunology;immunoregulation;Immunosuppression;Immunotherapy;In Vitro;in vivo;insight;interest;Invaded;Isogenic transplantation;Joints;Link;liquid biopsy;Macrophage;Malignant Neoplasms;Mechanics;mechanotransduction;Mediating;Membrane;metastasis prevention;Metastatic/Recurrent;Methods;Modeling;Modification;Molecular;mortality;mouse model;multi-scale modeling;multidisciplinary;Neoplasm Metastasis;neoplastic cell;Non-Invasive Detection;novel;Pathway interactions;Patients;PD-1/PD-L1;pharmacokinetic model;physical science;Play;prevent;Primary Neoplasm;Process;Production;protein transport;Publications;Research;Research Personnel;Resistance;response;Role;Signal Transduction;Site;T-Lymphocyte;Technology;Testing;Therapeutic Intervention;Tissues;trafficking;translational potential;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Tissue;Tumor-Derived;United States;Woman;women's treatment;Xenograft Model;Xenograft procedure

PROJECT_TITLE: A physical sciences approach to investigate the role of exosomes in metastatic progression


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE The goal of the proposed Penn Implementation Science Center in Cancer Control (Penn ISC3) is to advance the science and practice of implementing evidence-based practices for individuals with cancer. The creation of the Penn ISC3 will leverage the deep expertise and resources at the University of Pennsylvania in implementation science, behavioral economics, and cancer care delivery research to address strategic priorities emphasized in the National Cancer Institute Moonshot Blue Ribbon Panel. Specifically, our focus and grand challenge theme is to test implementation strategies informed by behavioral economics to improve uptake of evidence-based practices within our Implementation Laboratory, Penn Medicine, including those from traditionally underserved populations, to improve the lives of individuals with cancer. Penn ISC3 will produce new knowledge with the potential to reduce the research-to-practice gap in cancer care and improve outcomes for millions of Americans. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: BEIDAS, RINAD SARY;BEKELMAN, JUSTIN ;SCHNOLL, ROBERT ADAM (contact)

PROGRAM_OFFICER_NAME: VANDERPOOL, ROBIN CLINE

PROJECT_TERMS: Acceleration;Address;African American;American;Artificial Intelligence;Behavior;behavioral economics;bone;cancer care;Cancer Center;Cancer Control;Cancer Patient;care delivery;care outcomes;chemotherapy;clinical research site;Communication;Communities;comparative;Coupled;Data Pooling;Development;Economics;Ecosystem;effectiveness outcome;Ensure;Environment;Event;evidence base;Evidence based practice;Female;Foundations;Funding;Future;Goals;Grant;Health;Healthcare;heuristics;high reward;Hospitals;implementation determinants;implementation outcomes;implementation science;implementation strategy;improved;improved outcome;Incentives;Individual;infancy;innovation;insight;International;Knowledge;Laboratories;Latinx;Learning;lens;Link;Literature;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;Medicaid;Medical;Medicine;Metastatic Neoplasm to the Bone;Methods;multidisciplinary;National Cancer Institute;next generation;novel;Oncologist;Oral;Outcome;Patient Compliance;Patients;Pennsylvania;Pharmaceutical Preparations;Pilot Projects;programs;Psychology;Qualitative Methods;Recommendation;Research;Research Personnel;research to practice;Resources;Science;Scientist;shift work;Site;skeletal;success;symptom management;synergism;System;Technology;Testing;therapy adherence;timeline;Tobacco use;Tobacco Use Cessation;tool;Training;treatment as usual;Underserved Population;Uninsured;Universities;uptake;Variant

PROJECT_TITLE: Advancing the Quality of Cancer Care through Behavioral Economics and Implementation Science


NIH_SPENDING_CATS: Cancer;Dissemination and Implementation Research

PI_NAMEs: BEIDAS, RINAD SARY (contact)

PROJECT_TERMS: anti-cancer research;Area;behavioral economics;cancer care;Cancer Control;care delivery;Caring;Collaborations;Communication;Communities;Data;data sharing;Development;Discipline;Educational Activities;Ensure;Environment;Evaluation;experience;Funding;Goals;Growth;health care delivery;implementation science;improved;Interdisciplinary Study;Intranet;Laboratories;Malignant Neoplasms;Manuscripts;meetings;Methodology;Methods;Mission;Monitor;multidisciplinary;Newsletter;novel;Oncology;outreach;Pennsylvania;Pilot Projects;Policy Maker;Preparation;Principal Investigator;Problem Solving;programs;Public Health;Publications;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Scholars Program;Science;Series;Services;Site;Structure;success;Sum;synergism;Translating;United States National Institutes of Health;Universities;Vision;visiting scholar;Vocabulary;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Dissemination and Implementation Research;Health Services;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Palliative Care;Prevention;Tobacco;Tobacco Smoke and Health;Women's Health Research

PI_NAMEs: BUTTENHEIM, ALISON MEREDITH (contact)

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;American;Area;Artificial Intelligence;Behavior;behavioral economics;bone;cancer care;Cancer Center;Cancer Control;cancer therapy;care delivery;Caring;chemotherapy;Collaborations;comparative;Continuity of Patient Care;Data;Data Pooling;design;Development;Doctor of Philosophy;Ensure;evidence base;Evidence based practice;Funding;Grant;Health;Healthcare;heuristics;high reward;implementation science;implementation strategy;implementation study;improved;improved outcome;Incubators;Individual;infancy;innovation;insight;Investments;Laboratories;Leadership;Learning;lens;Life;Link;Literature;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;Methodology;Methods;Mission;multidisciplinary;Nature;Oral;Outcome;Patient Compliance;Patients;Pennsylvania;Pilot Projects;Prevention;Process;programs;Psychiatry;Public Health;Quality of Care;reduce tobacco use;Research;Research Activity;Research Personnel;Resources;response;Scientific Advances and Accomplishments;screening;survivorship;symptom management;Talents;Testing;therapy adherence;Tobacco use;Tobacco Use Cessation;Universities;uptake;Variant

PROJECT_TITLE: Research Program


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Cancer;Data Science;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: RELEVANCE (See instructions):  The proposed research is relevant to public health because the development and better utilization novel  machine learning for classifying non-cancer deaths in cancer patients is expected to reduce the morbidity  and mortality in these patients. Thus, the proposed research is relevant to the part of the NIH's mission  that pertains to developing fundamental knowledge that will help to lengthen human lives and reduce the  burdens of human illness.

PI_NAMEs: ZHANG, LANJING  (contact)

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: Address;Area;Awareness;cancer care;Cancer Model;Cancer Patient;Cancer Survivor;Categories;Cause of Death;Cessation of life;Collaborations;Colorectal Cancer;Creativeness;Data;Data Science;deep learning;Development;Economic Burden;Educational process of instructing;Electronic Health Record;explainable machine learning;Extramural Activities;Healthcare;high school;Human;improved;Instruction;interdisciplinary collaboration;Knowledge;Learning;learning network;Machine Learning;machine learning algorithm;machine learning classification;machine learning model;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Methods;Mission;Modeling;Morbidity - disease rate;mortality;neural network;novel;Outcome;Patients;Physicians;Population;Population Study;Problem Solving;prognostication;programs;Public Health;Recurrence;Research;Research Personnel;Risk;Schools;screening;Sensitivity and Specificity;SMART health;socioeconomics;Students;Technology;tool;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;Validation

PROJECT_TITLE: SCH: Screening and confirmatory machine learning for explainable modeling of non-cancer deaths in cancer patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: SHULMAN, LAWRENCE N. (contact)

PROJECT_TERMS: African American;Area;behavioral economics;Biometry;Board Certification;cancer care;Cancer Center;Cancer Control;Cancer Patient;chemotherapy;Clinical;clinical center;Clinical Informatics;Clinical Research;clinical research site;Clinical Services;clinical training;clinically relevant;Clinics and Hospitals;Collaborations;Communities;community based practice;Community Practice;computer science;Computerized Medical Record;County Hospitals;Data;Data Analyses;Data Collection;data dissemination;data management;Data Management Resources;Data Science;Data Security;Data Set;data sharing;Data Storage and Retrieval;Databases;Delaware;design;Development;Doctor of Medicine;Ecosystem;electronic recording system;Engineering;Ensure;Ethnic Origin;evidence base;experience;Female;forging;Future;General Hospitals;Gynecology;Hematology;Hospitals;implementation science;implementation strategy;improved;Informatics;Infrastructure;innovation;Internal Medicine;interoperability;Laboratories;Latinx;Leadership;Link;Malignant Neoplasms;Medicaid;Medical;Medical center;Medicine;member;Methods;New Jersey;Oncologist;Oncology;operation;Operative Surgical Procedures;Oral;Pathology;patient population;Patients;Pennsylvania;Pilot Projects;Population;Presbyterian Church;programs;Protocols documentation;Race;Radiation Oncology;Radiology Specialty;recruit;Research;Research Personnel;research study;Resources;Sampling;Sampling Studies;scale up;Secure;Security;Selection Criteria;Services;Site;socioeconomic diversity;Standardization;Structure;System;Testing;therapy adherence;Tobacco use;Translational Research;Uninsured;Universities;University Hospitals;Wisconsin;Work

PROJECT_TITLE: Implementation Laboratory


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Lung;Lung Cancer;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Small cell lung cancer (SCLC) is a highly aggressive, recalcitrant and deadly cancer with no effective treatment. We have found that SCLC leads to production of neoantigens and autoantibodies, the binding sequence of which can be engineered into chimeric antigen receptor T cells (CAR-Ts) that could provide a badly needed new avenue for SCLC treatment.

PI_NAMEs: HOUGHTON, A MCGARRY;LASTWIKA, KRISTIN J (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Antibodies;antigen binding;Antigen Targeting;Antigens;Autoantibodies;Autoantigens;B-Lymphocytes;Binding;Biological Markers;Biological Models;Blood;blood-based biomarker;Cancer cell line;cancer immunotherapy;Cancer Model;Cancer Patient;cancer survival;cancer therapy;CAR T cell therapy;Cell surface;Cells;chimeric antigen receptor T cells;Clinical;clinically relevant;Complex;cytokine;Data Set;design;Development;Diagnosis;Discrimination;Disease;Dose;Down-Regulation;effective therapy;engineered T cells;Engineering;Epitopes;exhaustion;Failure;Genetically Engineered Mouse;Hand;High Prevalence;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immune system;Immunity;Immunobiology;Immunocompetent;immunogenic;immunogenicity;Immunology;Immunosuppression;Immunotherapy;In Vitro;in vivo;in vivo evaluation;Infiltration;innovation;insight;leukemia;Libraries;Ligand Binding Domain;Liquid substance;Lymphoma;Major Histocompatibility Complex;Malignant neoplasm of lung;Malignant Neoplasms;Modeling;Molecular;mouse model;Multiple Myeloma;neoantigens;neoplastic cell;Neurologic;Normal tissue morphology;novel;novel strategies;Paraneoplastic Syndromes;patient derived xenograft model;Patients;Phenotype;Plasma;Post-Translational Protein Processing;pre-clinical;Pre-Clinical Model;preclinical study;Prevalence;Production;programmed cell death ligand 1;protein complex;receptor;response;Sensitivity and Specificity;Signal Transduction;small cell lung carcinoma;Smoking;Solid Neoplasm;success;Surface Antigens;Surrogate Markers;Survival Rate;Symptoms;Syndrome;T cell therapy;T-Cell Activation;Testing;TFRC gene;Therapeutic;Tissues;Toxic effect;TP53 gene;trafficking;Translating;tumor;Tumor Antigens;Tumor Tissue;tumorigenesis

PROJECT_TITLE: Translating Autoantibodies Into Chimeric Antigen Receptor-T cell Therapy for Small Cell Lung Cancer


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Hematology

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PI_NAMEs: BEACHY, PHILIP A;HSU, CHI-YUAN  (contact);WALTERS, MARK C

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Active Learning;Area;Basic Science;career;career development;Clinical Sciences;Creativeness;design;Development;Diagnosis;Discipline;Disease;Environment;experience;Faculty;Feedback;flexibility;Foundations;Funding;Future;Hematology;innovation;Institution;Investigation;Knowledge;Language;matriculation;Mentors;Mentorship;Methodology;multidisciplinary;National Research Service Awards;Nephrology;Non-Malignant;Pediatric Hematology;peer learning;Prevention;Productivity;programs;Research;Research Personnel;Research Training;resilience;Science;Scientific Inquiry;Scientist;skill acquisition;teacher;Teacher Professional Development;Technical Expertise;Training;Training Programs;Transcend;Translational Research;Urology

PROJECT_TITLE: NRSA Training Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Nutrition;Obesity;Prevention

ORG_CITY: WASHINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Precise optical scanning of 3D whole body shape is now possible with cheap commercial scanners available on smart phones and tablets. These cheap and accessible scans may hold a heretofore-untapped wealth of health- related information that can be utilized with machine learning. In this proposal, we use the technology to study the physiological and psychological effects in subjects with severe obesity.

PI_NAMEs: HAHN, JAMES K (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: 3-Dimensional;Adipose tissue;bariatric surgery;Biological Markers;Biopsy;Blood;Body Image;Body mass index;Body Surface;Body Weight decreased;Cartoons;Cellular Phone;Computer software;cost;cost effective;Data;data mining;Databases;Devices;Diagnosis;Diet;Dual-Energy X-Ray Absorptiometry;elastography;Evaluation;Explosion;Face;Fatty Liver;Fibrosis;Geometry;Health;high body mass index;high risk;Histologic;Image;innovation;insight;Intention;liver biopsy;Liver Fibrosis;Longitudinal Studies;Longitudinal, observational study;Machine Learning;machine learning algorithm;Measurement;Measures;Metabolic Marker;Metabolic syndrome;Methodology;Mining;Morbid Obesity;Morbidity - disease rate;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;obese person;Obesity;Operative Surgical Procedures;Optics;Patient Self-Report;Patients;Perception;Physical activity;Physiological;population based;Postoperative Period;prediction algorithm;predictive marker;psychologic;Psychological Factors;recruit;Research;Research Personnel;Risk;Scanning;sensor;Serum;Shapes;Specificity;success;Surface;Tablets;Techniques;Technology;Testing;tool;Training;Translating;Validation;Visceral;Waist-Hip Ratio;Weight;Work

PROJECT_TITLE: Advancing 3D optical body surface scan technology to assess physiological and psychological effects in highly obese population

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: AT

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Dietary Supplements;Emergency Care;Hematology;Nutrition;Orphan Drug;Pain Research;Pediatric;Rare Diseases;Sickle Cell Disease

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative: Pain is the hallmark of sickle cell disease (SCD), and is the leading cause of hospitalizations, emergency room visits, missed school, and is associated with an increased death rate. We found that patients with SCD and pain had low levels of the amino acid arginine in their blood, and we also demonstrated that arginine supplementation during acute pain events significantly reduced the amount of opioids needed to treat sickle cell pain in children and dramatically improved pain scores at discharge compared to placebo. We propose to investigate the benefits and safety of arginine for the treatment of patients with SCD and pain in a randomized, placebo-controlled clinical trial where neither the patient nor the clinical team know which therapy the patient is receiving, since Arginine is a promising nutritional therapy that could change the way we treat acute pain in SCD.

PI_NAMEs: MORRIS, CLAUDIA R (contact)

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: Absence of pain sensation;Academy;Accident and Emergency department;Acute;Acute Pain;Address;American;Amino Acids;Analgesics;Applied Research;Arginine;arginine treatment;Award;Blood;Cardiopulmonary;career;career development;Child;Childhood;Clinical;Clinical Nutrition;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Committee Members;Data;Death Rate;Development;Development Plans;dietary supplements;Dose;double-blind placebo controlled trial;Education;Educational Curriculum;Educational workshop;efficacy evaluation;Emergency Care;Emergency department visit;Emergency Medicine;Environment;Event;evidence base;Extramural Activities;Faculty;Fellowship;Fostering;Funding;Goals;graduate student;Grant;Hospitalization;Hydration status;improved;Infrastructure;Institution;Integrative Medicine;Integrative Therapy;interest;International;Intervention;Investments;Leadership;Length of Stay;Manuscripts;Master of Science;matriculation;Medical Students;Medicine;Mentors;Mentorship;metabolome;Mid-Career Clinical Scientist Award (K24);Mitochondria;National Center for Complementary and Integrative Health;National Heart, Lung, and Blood Institute;next generation;Nigeria;Nitric Oxide;novel therapeutics;Nutritional;Nutritional Science;Nutritional Study;Nutritional Support;Opioid;opioid sparing;opioid use;Oxidative Stress;Pain;Pain management;pain score;Patient Admission;patient oriented research;Patients;pediatric emergency;Pediatrics;Peer Review;Phase;phase III trial;Physicians;Placebos;Postdoctoral Fellow;Product Approvals;product development;Production;Productivity;Publications;Publishing;Randomized;randomized placebo-controlled clinical trial;Replacement Therapy;Research;Research Activity;Research Personnel;Resolution;Resource-limited setting;Role;Safety;Schools;Scientist;Sickle Cell;Sickle Cell Anemia;skills;success;Supplementation;Syndrome;Therapy trial;Time;TNFSF15 gene;Training;Translational Research;undergraduate student;Universities;Vasodilator Agents;Visit;willingness;Woman

PROJECT_TITLE: Patient-Oriented Research in Arginine Deficiency Syndromes


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Acute myelogenous leukemia (AML) is a lethal disease with limited therapeutic options. This grant proposal seeks to develop improved drug regimens to provide better treatment options for patients with AML.!

PI_NAMEs: JORDAN, CRAIG T. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;Applications Grants;BCL2 gene;Clinical Research;design;Development;Disease;Epigenetic Process;Genetic;Goals;Heterogeneity;Human;improved;improved outcome;inhibitor;interest;Intervention;leukemia;leukemic stem cell;Metabolic;Newly Diagnosed;Oxidative Phosphorylation;Patients;Pharmaceutical Preparations;Property;Regimen;Relapse;standard of care;stem cell biology;stem cell population;Therapeutic;therapeutic development;therapeutic target;Translations;Work

PROJECT_TITLE: Therapeutic Targeting of Human AML Stem Cells


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE A detection technology based on evanescent field scattering of protein oscillators will be developed to detect and identify proteins, and to analyze protein-protein interactions. The success of the project will lead to a powerful tool to study molecular scale processes in living organisms, to screen drugs and to detect biomarkers, particularly from low volume samples, such as single cells and exosomes.

PI_NAMEs: WANG, SHAOPENG  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Affinity;Antibodies;Binding;Binding Proteins;Biochemical Process;bioelectronics;Biological Markers;Biosensor;Buffers;Capillary Electrophoresis;Cells;Charge;Chemistry;Complication;Computer software;Consumption;cost;Coupled;density;Detection;detection platform;Diagnosis;Diameter;Disease;disease diagnosis;Drug Screening;electric field;Electrophoresis;Enzyme-Linked Immunosorbent Assay;exosome;experimental study;fabrication;flexibility;Frequencies;gel electrophoresis;Heterogeneity;Image;Imaging technology;In Situ;indium tin oxide;Individual;Industry;instrument;Kinetics;Label;Length;Ligand Binding;Ligands;Light;light scattering;Link;Measurement;Measures;Mechanics;Methods;Molecular;molecular marker;molecular scale;Neoplasm Circulating Cells;optical imaging;Organism;Pharmaceutical Preparations;Phase;Polymers;Process;Property;Protein Analysis;protein biomarkers;protein complex;protein protein interaction;Proteins;Protocols documentation;prototype;Research;Sampling;sensor;Signal Pathway;Signal Transduction;single molecule;Slide;success;Surface;Surface Plasmon Resonance;System;Technology;Testing;Time;tool;Western Blotting;Workload

PROJECT_TITLE: Optical imaging of size, charge, mobility and binding of single proteins

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE We are reapplying to include the Wisconsin Infant Study Cohort (WISC), involving a critical rural underserved population, in the next phase of the Environmental Influences on Child Health Outcomes (ECHO) program. Our area of specialization within ECHO is upper and lower airway disease. We propose innovative studies focusing on how early life factors interact with airway epithelial cells to promote asthma onset and persistence.

PI_NAMEs: GERN, JAMES E. (contact)

PROGRAM_OFFICER_NAME: ARTEAGA, SONIA S

PROJECT_TERMS: Adolescence;Adopted;Affect;Age;Air;Airway Disease;airway epithelium;airway obstruction;Animals;Antibiotics;Area;Asthma;Atopic Dermatitis;Biodiversity;Birth;Black race;Candidate Disease Gene;Caribbean Hispanic;Cells;Child;Child Health;Childhood;Childhood Asthma;Clinical;cohort;Cohort Studies;comorbidity;Dairying;Data;Data Pooling;demographics;Development;Disease;Disease remission;disorder control;disorder risk;Disparity;DNA analysis;DNA Methylation;early adolescence;Early identification;early life exposure;Economics;Emerging Technologies;Environment;Environmental Exposure;Environmental Risk Factor;Epithelial Cells;Ethnic Origin;Exposure to;Family;Farm;follow-up;Gene Expression;Genes;Genetic;Genetic Polymorphism;Geography;Goals;Gonadal Steroid Hormones;Health;health disparity populations;healthcare burden;Hormonal;Hospitalization;Hypersensitivity;Immune;Incidence;infancy;Infant;innovation;insight;Insulin Resistance;Life;Life Style;Link;Lung;Mental Depression;Meta-Analysis;Microbe;microbial;microbiome;Molecular;molecular phenotype;Neighborhoods;Nose;Nursery Schools;Outcome;Outcome Study;Parents;Participant;Pathogenicity;pediatric health outcomes;pet animal;Phase;Phenotype;Population;Population Density;Population Heterogeneity;postnatal;Poverty;prenatal;prevent;programs;Protocols documentation;Publishing;pulmonary function;Race;Recurrence;Regulation;Reporting;Resolution;respiratory;Respiratory Disease;respiratory morbidity;response;Rhinitis;Risk;Risk Reduction;Rural;rural area;Rural Community;rural families;Rural Population;rural underserved;Sampling;School-Age Population;Severities;sex;Stress;Syndrome;System;Testing;Underserved Population;United States National Institutes of Health;Update;Viral;Wheezing;Wisconsin

PROJECT_TITLE: Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-Up

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Emergency Care;Health Services;Patient Safety

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Emergency department (ED) providers admit nearly all patients with acute heart failure (AHF). Some tools exist to aid in identifying AHF patients safe for discharge, but they are largely unused due to poor validation and lack of effective deployment and implementation. We developed and validated an AHF tool to safely facilitate ED discharge, and this study aims to overcome implementation barriers through a clinical decision support-based implementation strategy.

PI_NAMEs: KRIPALANI, SUNIL ;LIU, DANDAN ;STORROW, ALAN B (contact)

PROGRAM_OFFICER_NAME: PLEVOCK HAASE, KAREN MARIE

PROJECT_TERMS: Accident and Emergency department;Accountability;Acute;acute care;Address;Admission activity;Adoption;Adverse event;Algorithms;Beds;biomedical informatics;Biometry;Caregivers;Caring;Characteristics;Chronic Obstructive Pulmonary Disease;Clinical;clinical decision support;clinical practice;Clinical Research;clinical research site;Clinical stratification;Complex;Consolidated Framework for Implementation Research;Data;data integration;Decision Making;design;Disease;Disease Management;Dissemination and Implementation;effectiveness evaluation;Electronic Health Record;electronic health record system;electronic structure;Emergency Care;Emergency Department evaluation;Emergency Department patient;Emergency Department Physician;Emergency Medicine;Event;Face;Focus Groups;Geography;Goals;Grant;health care delivery;Health Expenditures;Health Status;Heart failure;high risk;Home;hospital readmission;Hospitalization;Hospitals;Hour;implementation barriers;implementation outcomes;implementation process;implementation science;implementation strategy;implementation study;improved;innovation;insight;Institution;interdisciplinary collaboration;Interruption;Leadership;Medical;Methods;Modeling;Motivation;multidisciplinary;National Heart, Lung, and Blood Institute;novel;pandemic disease;Patient Care;patient-clinician communication;Patient-Focused Outcomes;Patients;Pattern;Penetration;Positioning Attribute;practice setting;predictive modeling;predictive tools;pressure;Process;Provider;Publishing;Pulmonary Embolism;Qualitative Research;Recommendation;Research;Resources;response;Risk;Risk Factors;risk prediction;risk prediction model;safe patient;Scientist;Series;shared decision making;Site;Statistical Algorithm;Statistical Methods;Stroke;success;support tools;Testing;Time;tool;Update;usability;user centered design;Validation;virtual;Work

PROJECT_TITLE: Tailored dissemination and implementation of emergency care clinical decision support to improve emergency department disposition

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Modern human genetics has provided remarkable insights into the molecular basis of cancer, but many genetically-defined cancer targets lack chemical probes and are even considered potentially undruggable. The goal of this research program is to leverage our lab’s pioneering chemical proteomic technologies to radically expand the druggable content of human cancer cells for the creation of chemical probes and, ultimately, therapeutics for biologically compelling human cancer targets.

PI_NAMEs: CRAVATT, BENJAMIN F (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Acceleration;activity-based protein profiling;adaptive immunity;anti-cancer research;Basic Science;Biological Response Modifier Therapy;biological systems;Biology;cancer cell;cancer therapy;Cells;Chemicals;Code;Development;DNA sequencing;Future;gene discovery;genetic information;Goals;Human;Human Genetics;Immune;Immunology;Immunooncology;innovation;insight;Knowledge;Malignant Neoplasms;Maps;Medicine;Methods;Modernization;Molecular;Mutate;Natural Immunity;novel therapeutics;Oncogenes;pharmacologic;Play;programs;protein degradation;Proteins;Proteome;Proteomics;Research;Role;small molecule;small molecule libraries;System;technological innovation;Technology;Therapeutic;Translating;Translational Research;tumorigenesis;ubiquitin-protein ligase;Validation

PROJECT_TITLE: Chemical Proteomic Platforms for Radically Expanding Cancer Druggability


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hematology;Liver Disease;Pediatric

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative The accuracy of conventionally available R2*-MRI for liver iron quantification is negatively affected by patient motion and a high concentration of iron as commonly seen in patients with transfusion-induced iron overload. Accurate liver iron quantification is critical for managing iron overload and evaluating the efficacy of chelation treatment aimed at reducing body iron stores while minimizing adverse effects of chelator administration. This project will develop a rapid, motion-tolerant, and free-breathing abdominal R2*-MRI method, providing high- resolution volumetric liver R2* images for accurate iron quantification.

PI_NAMEs: KEE, YOUNGWOOK  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Abdomen;accurate diagnosis;Address;Adult;Adverse effects;Affect;Algorithms;Anemia;Biliary;Biological Markers;Blood Transfusion;Body Image;Body System;Breathing;Cancer Patient;Cardiomyopathies;Cardiotoxicity;Caucasians;Chelating Agents;chelation;Chelation Therapy;Child;Childhood;chronic liver disease;Clinical;Clinical Management;Clinical Research;cluster computing;Cone;Contrast Media;Data;data acquisition;data space;Delayed Puberty;design;Development;Diagnosis;Dimensions;Directories;efficacy evaluation;Endocrine;Ethnic Origin;experience;Failure;Ferritin;Functional disorder;Genetic;Goals;Growth;Head;Hematologic Neoplasms;Hematological Disease;Hemochromatosis;Hemosiderosis;Hepatic;Hepatology;Hereditary hemochromatosis;high dimensionality;Image;Image Analysis;Image Compression;image reconstruction;imaging biomarker;Impairment;improved;Individual;Inferior;innovation;intravenous administration;Ionizing radiation;Iron;Iron Overload;iron oxide nanoparticle;Left;Liver;liver biopsy;Liver Fibrosis;liver imaging;Macrophage;magnetic field;Magnetic Resonance Imaging;Malignant Neoplasms;Measurement;Methodology;Methods;Microscopic;Modeling;Monitor;Morbidity - disease rate;Motion;Motivation;Movement;multidisciplinary;Not Hispanic or Latino;novel;Organ;Outcome;Pancreas;Patients;pediatric patients;Performance;pharmacologic;Physicians;Population;Primary carcinoma of the liver cells;Process;quantitative imaging;Race;radiologist;Reader;reconstruction;Relaxation;Research;research clinical testing;Resolution;respiratory;Risk;Sampling;Scanning;Scheme;side effect;Signal Transduction;Slice;Sorting;spatiotemporal;Speed;standard of care;Structure;superparamagnetism;Techniques;Testing;Thick;Time;tissue oxygenation;Tissues;Transfusion;United States;Venous blood sampling;Wait Time;Work

PROJECT_TITLE: Rapid Free-Breathing 3D High-Resolution MRI for Volumetric Liver Iron Quantification

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases;Lung

ORG_CITY: Nashville

ORG_DEPT: CHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Public Narrative  There is a need for simple, rapid, and cost-effective methods for detecting and differentiating infections that present with similar symptoms but require different treatment and management strategies. This is particularly important for respiratory infections, including COVID-19 and influenza, which can spread quickly through the population. We propose to develop a simple-to-use and cost-effective respiratory panel suitable for use in urgent care clinics and physicians’ offices that will rapidly identify COVID-19, influenza, and other viral/bacterial infections directly from nasopharyngeal swab samples with no required sample preparation.

PI_NAMEs: HASELTON, FREDERICK R (contact);SCHMITZ, JONATHAN E

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Academic Medical Centers;amplification detection;Bacteria;Bacterial Infections;Biochemical;Biomedical Engineering;Characteristics;CLIA certified;Clinic;Clinical;clinically relevant;Collaborations;Containment;cost;cost effective;COVID-19;COVID-19 assay;COVID-19 detection;COVID-19 diagnostic;COVID-19 pandemic;COVID-19 testing;Data;design;detection method;Device Designs;Devices;Diagnosis;Diagnostic;diagnostic assay;DNA;enantiomer;Engineering;Environment;Epidemiology;experience;follow-up;Goals;Health;Human;Image;Infection;Infection prevention;Infectious Diseases Research;Influenza;instrument;instrumentation;Laboratories;Light;Methodology;Methods;Molecular;Molecular Diagnosis;molecular diagnostics;Monitor;multiplex assay;nasopharyngeal swab;novel;Nucleic Acids;Optics;pathogen;Patients;Performance;Physicians;Physicians' Offices;point of care;point-of-care diagnostics;Population;preclinical evaluation;Preparation;primary care setting;Public Health;Reaction;Reagent;Reporting;research clinical testing;Resource-limited setting;Resources;respiratory;respiratory pathogen;Respiratory Tract Infections;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA Viruses;RNase P;Sampling;Sensitivity and Specificity;Specificity;Specimen;Supportive care;Symptoms;System;Technology;technology validation;Temperature;Tennessee;Testing;Time;tool;Training;Tube;urgent care;Viral;Virus;Work

PROJECT_TITLE: Point-of-Care RT-PCR System to Inform COVID-19 and Respiratory Illness Decisions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-R(02)M]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Maternal Health;Maternal Morbidity and Mortality;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: Fairfax

ORG_NAME: INOVA HEALTH CARE SERVICES

ORG_STATE: VA

PHR: Project Narrative Prevention of postpartum hemorrhage using antifibrinolytic therapy, specifically tranexamic acid, has great potential in the field of obstetrics. We will conduct a clinical pharmacokinetic study to find the lowest drug dose that will be needed for optimal hemostasis when tranexamic acid is given prior to delivery so maternal benefit is maximized and fetal/neonatal risk is minimized. Ultimately, this translational research is critical to better understanding the role tranexamic acid will have to prevent postpartum hemorrhage and maternal deaths worldwide.

PI_NAMEs: AHMADZIA, HOMA KHORRAMI (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Address;Adoption;Advocate;Affect;Antifibrinolytic Agents;antithrombin III-protease complex;Biological Markers;Biometry;Birth;Blood Transfusion;Cesarean section;Cessation of life;Child;Childbirth;Circulation;Clinical;Clinical Pharmacology;Clinical Sciences;Clinical Trials;Closure by clamp;Coagulation Process;cohort;Communities;Data;Discipline of obstetrics;Disparity;Dose;Drug Kinetics;Environment;Epidemiology;Equilibrium;Event;Exclusion;experience;Exposure to;falls;fetal;Fibrin;Fibrin fragment D;Generic Drugs;Goals;Grant;Hemorrhage;Hemostatic Agents;Hemostatic function;High Risk Woman;Hospitals;Human Milk;Improve Access;improved;Infusion procedures;innovation;International;Intervention;Intramuscular;Intramuscular Injections;Intravenous;intravenous administration;Intravenous Bolus;Intravenous infusion procedures;Knowledge;Maryland;maternal morbidity;Maternal Mortality;maternal risk;maternal safety;Maternal-fetal medicine;Measures;Medicine;member;Methods;Morbid Obesity;multidisciplinary;Nature;Nausea and Vomiting;Neonatal;neonatal exposure;Newborn Infant;North Carolina;novel strategies;Obesity;Operative Surgical Procedures;Outcome;Outcome Study;Patients;Perinatal;Pharmaceutical Preparations;pharmacodynamic model;pharmacokinetics and pharmacodynamics;pharmacologic;pharmacometrics;placental transfer;Population;Postpartum Hemorrhage;Postpartum Period;Pregnancy;Pregnant Women;Prevalence;prevent;Prevention;Prevention approach;Procedures;prophylactic;Prophylactic treatment;Randomized;Reporting;Research;Resource-limited setting;Risk;Risk Assessment;Role;Route;Safety;Sample Size;Sampling;side effect;Site;special interest group;Subgroup;Testing;Therapeutic;Thrombolytic Therapy;Thrombosis;thrombotic;Tranexamic Acid;translational medicine;Translational Research;Trauma;Umbilical Cord Blood;Umbilical cord structure;Umbilicus;United States;Universities;Vagina;Vaginal delivery procedure;Woman;Work

PROJECT_TITLE: OPTIMUM OB-TXA: Optimal TIMing, route and dose of tranexamic acid prior to UMbilical cord clamp for postpartum hemorrhage prevention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-S(55)R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetic Testing;Genetics;Muscular Dystrophy;Neurosciences;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Inherited and acquired forms of muscle weakness lead to significant morbidity and mortality. At present, 50% of patients have variants of unknown significance in genes associated with inherited forms of muscle weakness. This proposal will develop tools to assess genetic variants for potential pathogenicity and understand the phenotypic progression of these diseases.

PI_NAMEs: WEIHL, CONRAD C (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Affect;Animal Model;Archives;Area;Award;Benign;biobank;Biological;Biological Assay;Biological Markers;biomarker development;biomarker discovery;biomedical referral center;career;Cell model;Clinical;Clinical Investigator;clinical outcome assessment;clinical outcome measures;clinical phenotype;Clinical Research;Clinical Trials;ClinVar;cohort;Cross-Sectional Studies;Deposition;Development;Diagnosis;Disease;Disease Progression;Distal;diversity and inclusion;Faculty;Family;Feeds;Fibroblasts;Funding;Future;Gene Mutation;Genes;Genetic;Genetic Diseases;genetic information;genetic pedigree;genetic testing;genetic variant;Goals;graduate student;Grant;improved;Individual;Inherited;interest;International;K-Series Research Career Programs;Kansas;Laboratories;Lead;Learning;Limb-Girdle Muscular Dystrophies;Measures;medical schools;member;Mentors;Mentorship;Midcareer Investigator Award in Patient-Oriented Research;Molecular;Morbidity - disease rate;mortality;Muscle;muscle form;Muscle Weakness;Mutation;Myopathy;Natural History;Neurology;neuromuscular;next generation;novel;novel diagnostics;Participant;participant enrollment;Pathogenesis;Pathogenicity;Pathologic;patient oriented research;Patients;Pelvis;Phenotype;Physicians;Policies;Positioning Attribute;Postdoctoral Fellow;preclinical efficacy;Prevalence;programs;Proteins;Publishing;Rare Diseases;Registries;Research;research clinical testing;Research Infrastructure;Research Proposals;Resolution;Saliva;Sampling;Scientist;Shoulder;Site;skills;Standardization;student mentoring;Students;therapeutic target;Time;tool;Training;Training Support;Translational Research;translational study;United States;Universities;Variant;variant of unknown significance;Virginia;Visit;Washington

PROJECT_TITLE: Clinical and Translational studies in muscle disease

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Dissemination and Implementation Research;Drug Abuse (NIDA only);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse;Women's Health Research

PHR: PROJECT NARRATIVE The increasing prevalence of pregnant and postpartum women affected by Opioid Use Disorder (OUD) in the US is highlighted by the growing number of babies referred to the NICU for Neonatal Abstinence Syndrome after birth. Despite recent advances in integrating mental health and substance abuse treatment into adult healthcare settings, no current treatment models exist to integrate maternal OUD treatment and referrals into the pediatric care setting making it unlikely that mothers will be able to access care. In order to preserve the dyadic bond, improve maternal functioning, and provide a more stable environment for the infant, we now embark on a study utilizing steps from implementation mapping to identify facilitators and barriers to integrated maternal OUD treatment and referral in the NICU, adapt existing evidence-based models of co-located OUD care to the NICU setting, refine our new interventions, and examine the feasibility and acceptability of our new model.

PI_NAMEs: KORNFIELD, SARA L. (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Affect;behavior change;behavioral health;Birth;Buprenorphine;Caring;Case Series;Child health care;Childhood;Clinical;Collaborations;Communities;community advisory board;Consolidated Framework for Implementation Research;critical period;Data;design;Diagnosis;Discipline of obstetrics;Dropout;effectiveness/implementation hybrid;effectiveness/implementation study;Environment;evidence base;Feedback;follow-up;Future;Goals;health assessment;health care settings;Health Services Accessibility;Healthcare;Hospitals;implementation barriers;implementation design;implementation strategy;improved;Infant;Intensive Care Units;Intervention;intervention mapping;Interview;Manuals;Maps;maternal opioid use;maternal outcome;medication for opioid use disorder;Mental Health;mental set;Modeling;Mothers;Neonatal Abstinence Syndrome;Neonatal Intensive Care Units;opioid use disorder;opioid withdrawal;Outcome;Parents;Patients;pilot test;postpartum health;Postpartum Period;Postpartum Women;Practice Guidelines;Pregnant Women;prenatal;Preparation;preservation;Prevalence;prevent;Process;Protocols documentation;Provider;provider behavior;Psychological Factors;Recommendation;Research;Resources;Role;screening;Site;Structure;substance abuse treatment;Suggestion;Testing;Time;willingness;Woman

PROJECT_TITLE: An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS care

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ORG_CITY: AUGUSTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Overall: Project Narrative The Vision Research Core Grant will provide crucially needed expertise/instrumentation to enhance research related to the visual system under normal and diseased conditions. To achieve this goal, facilities, services and shared instrumentation have been organized into three modules: (1) Visual Function Assessment; (2) Histology and Imaging; (3) Gene Expression/Proteomics. These modules will enhance the capability of vision researchers to engage in high impact research/discovery for patients suffering from blindness and visual disorders.

PI_NAMEs: LIU, YUTAO  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Allied Health Sciences;Award;Basic Science;Blindness;Center Core Grants;Clinical;clinically relevant;cohort;Collaborations;college;Communication;Core Grant;Dentistry;Development;Discipline of Nursing;Disease;Doctor of Philosophy;Ensure;Equipment;Financial Support;Funding;Gene Expression;Goals;Grant;Group Meetings;Health Sciences;Healthcare;Histology;Human Resources;Image;Infrastructure;Institution;instrumentation;Investigational Therapies;investigator training;Laboratories;medical schools;Methodology;Mission;Names;Ophthalmologist;Patients;Pilot Projects;Productivity;programs;Proteomics;recruit;Research;research faculty;Research Personnel;Research Project Grants;Research Support;Resources;Schools;Scientist;Series;Services;success;Talents;Technology;Time;Travel;undergraduate student;Universities;Vision;Vision Disorders;Vision research;vision science;Visual System

PROJECT_TITLE: Center Core Grant for Vision Research


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: SMITH, SYLVIA B. (contact)

PROJECT_TERMS: Accounting;Address;Advisory Committees;Center Core Grants;Collaborations;Communication;Communities;Core Grant;Disease;Electronics;Ensure;Exercise;Faculty Recruitment;Funding;Future;Gene Expression;Grant;Group Meetings;Histology;Image;instrumentation;meetings;member;new technology;operation;organizational structure;Outcome;Preparation;Productivity;Progress Reports;Proteomics;recruit;Reporting;Research;research faculty;Research Personnel;Resources;Schedule;service delivery;Services;skills;Specialist;System;Talents;Universities;Vision;Vision research

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

PROJECT_TERMS: Address;Age related macular degeneration;Animal Experimentation;Animal Model;Architecture;Center Core Grants;clinically relevant;Collaborations;Corneal dystrophy;Development;Diabetic Retinopathy;Disease;disease natural history;Doctor of Philosophy;Electroretinography;Equipment;Evaluation;Eye;Fluorescein Angiography;Funding;Future;Glaucoma;Goals;Human;image guided;imaging system;in vivo;in vivo imaging;Individual;instrument;instrumentation;Intervention;investigator training;Laboratories;laboratory experience;Laboratory Personnel;member;microscopic imaging;novel;Optical Coherence Tomography;Outcome;Patients;Physiologic Intraocular Pressure;Process;Productivity;Publications;Research Personnel;Research Project Grants;Resolution;Resources;response;Retina;retinal imaging;Retinitis Pigmentosa;Scientist;Services;skills;slit lamp imaging;Structure;System;Testing;Time;tool;Training;Treatment outcome;Vision;Vision research;Visual System

PROJECT_TITLE: Module 1: Visual Function Assessment


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: FAN, XINGJUN  (contact)

PROJECT_TERMS: Blindness;Cells;Center Core Grants;Data;Detection;Disease;DNA Sequence Alteration;Doctor of Philosophy;Electron Microscopy;Electrons;experimental study;Funding;Genetic Diseases;Goals;Histologic;Histology;Image;Image Analysis;Individual;instrument;instrumentation;Laboratories;laser capture microdissection;Laser Scanning Confocal Microscopy;Location;member;Methods;Microscope;Microscopic;Morphology;multi-photon;multiphoton microscopy;Patients;Process;Production;protein protein interaction;Proteins;Publications;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;sample fixation;Scientist;Services;skills;Stains;superresolution microscopy;Technical Expertise;Technology;tissue processing;Tissues;Training;Vision;Vision Disorders;Vision research;Visual System;Visualization

PROJECT_TITLE: Module 2: Histology and Imaging


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

PROJECT_TERMS: Affect;Aqueous Humor;Awareness;bead chip;Bioinformatics;Biological Markers;cDNA Arrays;Center Core Grants;Consultations;Cornea;Data;Data Analyses;design;Development;Devices;Disease;Disease Progression;Experimental Designs;experimental study;Expression Profiling;Funding;Future;Gene Chips;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Proteins;Genetic Transcription;Genomics;Goals;high throughput technology;insight;instrument;large datasets;lens;liquid chromatography mass spectrometry;mass spectrometer;Mass Spectrum Analysis;Measurement;new technology;next generation sequencing;novel;Oligonucleotide Microarrays;Onset of illness;Pathway Analysis;Pathway interactions;Post-Translational Protein Processing;Preparation;protein expression;Proteome;Proteomics;Protocols documentation;Research Personnel;Retina;RNA analysis;Sampling;Scientist;Services;single-cell RNA sequencing;Speed;Spottings;System;Technology;Tissues;Trabecular meshwork structure;Transcript;transcriptome;transcriptome sequencing;Universities;Validation;Vision;Vision Disorders;Vision research;Visual;Visual System

PROJECT_TITLE: Module 3: Gene Expression/Proteomics


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Neurosciences;Pain Research;Physical Activity

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Lumbar spinal stenosis, a common condition in older adults, can cause pain and difficulty walking (i.e., intermittent neurogenic claudication - INC). Patients with INC not infrequently undergo spinal surgery that fails to help them 1/3-1/2 the time. The purpose of this multi-site feasibility study is to prepare for the conduct of a randomized controlled trial to test the efficacy of manual therapy, exercise, and intramuscular electroacupuncture in reducing pain and improving walking ability for those with INC, and ultimately limiting the need for surgical referrals.

PI_NAMEs: DOUGHERTY, PAUL E;WEINER, DEBRA KAYE (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Acupuncture Therapy;Address;Adherence;Adrenal Cortex Hormones;Analgesics;Anti-Inflammatory Agents;associated symptom;Body mass index;Boston;Caring;Characteristics;claudication;Clinical;Clinical Practice Guideline;Clinical Trials;clinically significant;Communities;comorbidity;Complementary Health;Data;Data Collection;design;Documentation;efficacy testing;efficacy trial;Electroacupuncture;emotional functioning;evidence base;Exercise;experience;Failure;Feasibility Studies;flexibility;Fostering;functional improvement;Future;Healthcare;Home;Image;improved;Injections;Integrative Medicine;Intermittent Claudication;Intervention;intervention delivery;Intramuscular;Laminectomy;Life;Lower Extremity;Manipulative Therapies;Measures;Medical;Medical center;meetings;men;Methods;Modeling;Modification;Monitor;Morbidity - disease rate;National Center for Complementary and Integrative Health;older adult;Operative Surgical Procedures;opioid use;Oral;Pain;Pain management;pain reduction;Paresthesia;Participant;participant retention;Patient Care;patient engagement;Patients;Persons;Pharmaceutical Preparations;Phase;Physical therapy;Population;Positioning Attribute;Preparation;prescription opioid;Prevalence;primary care patient;primary endpoint;primary outcome;Procedures;Prospective, cohort study;Protocols documentation;Provider;provider intervention;Quality of life;Questionnaires;Randomized;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Resources;response;Site;Smoking;sociodemographics;Spinal Stenosis;Spine surgery;Standardization;Stenosis;Strategic Planning;symptom management;Testing;Time;Toxic effect;Training;treatment guidelines;United States;Vertebral column;Veterans;Walking;Woman;Work

PROJECT_TITLE: Optimizing Impact of Manual Therapy and Exercise on Lumbar Spinal Stenosis with Neurogenic Claudication: A Multi-Site Feasibility Study


NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision

ORG_CITY: Columbus

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The size and shape of the ocular lens are essential to proper health and function. However, the mechanisms governing adult lens shape have not been characterized. In this project, we will systematically study how biomechanical interactions in the lens fiber cells and the lens capsule interact to give the lens its shape.

PI_NAMEs: REILLY, MATTHEW A (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Adult;Age;age related;age related changes;aged;Aging;Architecture;Automobile Driving;biomechanical engineering;biomechanical test;Biomechanics;capsule;Cataract;Cell Compartmentation;Computational Technique;cost;Crystalline Lens;Development;driving force;Economics;Elasticity;Equilibrium;Exercise;Eye;fiber cell;Future;Gelatin;Growth;Health;Human;improved;innovation;Intervention;Knowledge;Length;lens;lens capsule;Lens Fiber;lens morphogenesis;Medical Care Costs;Modeling;Myopia;novel;Optics;Pattern;Presbyopia;prevent;Productivity;Property;Risk Factors;Shapes;soft tissue;theories;Therapeutic;Therapeutic Intervention;Time;United States;Water

PROJECT_TITLE: Biomechanics of Lens Morphogenesis

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: This proposal aims to define molecular mechanisms regulating formation of specific subcortical circuits that potentially mediate visually-driven defensive behaviors. Proper neuronal connectivity within specific circuits underlies appropriate behavioral responses, and defective developmental wiring often disrupts such behaviors in a variety of neurological disorders. The success of the proposed project should provide new insights into assembly of the neural circuits conveying reactions to the visual threat and help us understand both function and dysfunction of fear-related brain circuitry.

PI_NAMEs: KIM, IN-JUNG  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Affect;Area;Axon;Behavior;Behavioral;behavioral response;Binding;Brain;brain circuitry;cadherin-6;Candidate Disease Gene;Cells;contactin;Cues;Development;Dorsal;ETV1 gene;Event;experience;experimental study;Fright;Functional disorder;gain of function;Genes;genetic approach;Goals;improved;innovation;insight;Knock-out;Label;Lateral Geniculate Body;Lateral posterior nucleus of thalamus;loss of function;Maintenance;Mediating;Midbrain structure;Molecular;Molecular Genetics;Motor;Mus;mutant;Mutant Strains Mice;Nervous System Disorder;neural circuit;Neurologic;Neurons;Neurophysiology - biologic function;novel;Orphan;Output;overexpression;Pathway interactions;Pattern;Phenocopy;Phenotype;Play;Reaction;receptor;receptor expression;Regulation;Reporting;response;Retina;Retinoids;Role;screening;Sensory;sensory input;Stimulus;Structure;success;superior colliculus Corpora quadrigemina;Testing;Thalamic Nuclei;Thalamic structure;Time;transcription factor;transcriptome sequencing;Visual;Visual impairment;visual stimulus;Wild Type Mouse

PROJECT_TITLE: Molecular Genetics of Visual Circuit Assembly in the Developing Superior Colliculus

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: IRVINE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Picornaviruses are significant pathogens worldwide, causing some of the highest levels of human morbidity of all known viruses. These RNA-containing viruses include human rhinovirus, poliovirus, coxsackievirus, enterovirus 71, enterovirus D68, and many others. The project described in this application will explore how rhinoviruses hijack specific nuclear proteins during infection of human cells to carry out functions essential for viral replication in the cytoplasm.

PI_NAMEs: GERSHON, PAUL D;SEMLER, BERT L (contact);SHI, YONGSHENG

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Address;Animal Diseases;Anti-viral Agents;Anti-viral Therapy;Behavior;Biogenesis;Cell Line;Cell Nucleus;Cell Physiology;cell type;Cells;Cellular biology;Code;cohort;Common Cold;Complement;Complex;Coxsackie Viruses;Cytoplasm;Data;Data Set;Disease;Drosophila genus;Encephalitis;Enterovirus;Enterovirus 68;Enterovirus 71;Environment;Eukaryota;experimental study;Family;Family Picornaviridae;Foot Diseases;Gene Expression;Genes;genomic RNA;Hand's disease;Hela Cells;Hepatitis;Hepatitis A Virus;Human;human disease;human morbidity;Human poliovirus;Infection;insight;Knowledge;Lung;Mass Spectrum Analysis;member;Messenger RNA;Molecular;Molecular Biology;Morbidity - disease rate;Mouth Diseases;Myocarditis;Nonstructural Protein;novel;novel virus;Nuclear;Nuclear Pore;Nuclear Protein;Nuclear Proteins;Nuclear RNA;Open Reading Frames;Paralysed;pathogen;Pattern;Peptide Hydrolases;Play;Poliomyelitis;Polyadenylation;Pre-mRNA Polyadenylation Factor;Process;Proliferating;Protein Analysis;protein distribution;protein expression;Protein Family;Protein Splicing;Proteins;Proteome;Publications;Publishing;Reporting;respiratory;Respiratory Tract Infections;respiratory virus;Rhinovirus;Rhinovirus infection;RNA;RNA replication;RNA Sequences;RNA Splicing;RNA Viruses;RNA-Binding Proteins;Role;Series;Structural Protein;Symptoms;trafficking;Translations;transmission process;Transport Process;Validation;Viral;Viral Nonstructural Proteins;Viral Proteins;viral RNA;Virion;Virus;virus host interaction;Virus Replication

PROJECT_TITLE: Nuclear functions co-opted by human rhinovirus during replication in the cytoplasm of infected cells

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Diabetes;Neurosciences;Pediatric;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Type 1 diabetes (T1D) is associated with significant micro- and macrovascular complications, increased risk of shortened life span, and impacts on the brain and cognition that lead to significant personal costs and public health burdens that are likely to increase in line with increased T1D incidence. The CLARiFY study will document the mid-adult outcomes of childhood-onset T1D in a cohort followed at intervals for 30 years from diagnosis, and use these collective data to define which metabolic insults are most detrimental to the brain/cognition and at which age/stage of neurodevelopment. This information will allow clinicians to offer optimal clinical management designed to achieve good metabolic outcomes, while at the same time protecting the developing brain and preserving cognitive function.

PI_NAMEs: BEARE, RICHARD ;CAMERON, FERGUS ;FELDMAN, EVA LUCILLE (contact)

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: 6 year old;Acute;Adult;Adverse effects;Age;Belief;Blood Vessels;Brain;brain health;brain volume;Cerebrum;Child;Childhood;Childhood diabetes;Chronic;Clinical;Clinical Management;Cognition;Cognitive;cognitive change;Cognitive deficits;cognitive function;cognitive performance;cognitive retraining;cognitive skill;cohort;Cohort Studies;Community Health;Complications of Diabetes Mellitus;cost;Cross-Sectional Studies;Data;Data Collection;design;Diabetes Mellitus;Diabetic Ketoacidosis;Diagnosis;Disease;Disease susceptibility;early childhood;Educational Intervention;emerging adult;evidence base;Exhibits;Exposure to;follow-up;functional outcomes;Future;Glycosylated hemoglobin A;Goals;Growth;Health;Hyperglycemia;Hypoglycemia;Impaired cognition;Incidence;Individual;individualized medicine;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Knowledge;Life;Life Cycle Stages;life span;longitudinal analysis;Longitudinal Studies;macrovascular disease;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Metabolic;Microvascular Dysfunction;Morbidity - disease rate;neurodevelopment;neurotoxic;neurotoxicity;Outcome;Participant;Pediatric Hospitals;Perfusion;Population;Predisposition;prepuberty;preservation;Prevalence;prevent;prospective;Prospective Studies;Public Health;Recording of previous events;Research;resilience factor;Risk;Risk Assessment;Risk Factors;Stratification;Testing;Time;treatment strategy;Well in self;Work;Youth

PROJECT_TITLE: Identifying lifelong factors that impact brain health and outcomes in type 1 diabetes: The Cognition and Longitudinal Assessments of Risk Factors over 30 Years (CLARiFY) Diabetes Complications Study

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Hearing Loss;Pediatric;Physical Rehabilitation;Rehabilitation

ORG_CITY: WASHINGTON

ORG_NAME: GALLAUDET UNIVERSITY

PHR: PROJECT NARRATIVE: Children with multisensory vision and hearing loss (DeafBlindness) experience extreme delays in exposure to language, negatively impacting cognitive development and quality of life. This project aims to test whether a new, fully tactile language called protactile, used in interactions with DeafBlind adults, can support DeafBlind children’s development. Results will inform future early interventions for DeafBlind children and their families.

PI_NAMEs: GAGNE, DEANNA  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Achievement;Activities of Daily Living;Address;Adult;Age;blind;Blindness;Child;Child Development;Childhood;Cognition;Cognitive;cognitive ability;cognitive development;Communication;comorbidity;congenital deafness;Coupled;critical period;deaf;Deafblind;Development;Devices;Discrimination;Early Intervention;Education;experience;Exposure to;Family;family support;Future;habituation;haptics;Hearing;hearing impairment;Heart Rate;heart rate monitor;Home;improved;indexing;Infant;innovation;Intervention;Language;Language Delays;Language Development;Learning;Life;Linguistics;Link;longitudinal design;Longitudinal Studies;mathematical ability;Measurable;Measures;multisensory;Pattern;Perception;Play;prevent;prototype;Quality of life;rate of change;Rehabilitation therapy;Reporting;Research;Resources;scaffold;Sensory;Shoes;Sign Language;skills;Specific qualifier value;stem;Stimulus;Strategic Planning;Structure;success;Tactile;Testing;Time;Touch sensation;Treatment Efficacy;United States National Institutes of Health;Visual;visual stimulus;Vocabulary;wearable device

PROJECT_TITLE: Evaluating the rehabilitative potential of tactile number expressions for multisensory vision and hearing loss using wearable haptics


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH Influenza A virus (IAV) strains, many with pandemic potential and the ability to cause severe disease, trigger the death of most cell types in which they replicate. This proposal will continue our efforts to understand how IAV activates cell death, and how such cell death drives IAV pathogenesis, anti-IAV host defense, and host- virus coevolution across species.

PI_NAMEs: BALACHANDRAN, SIDDHARTH  (contact)

PROJECT_TERMS: Alveolar Macrophages;Amino Acids;anti-influenza;Apoptosis;Birds;Cell Death;Cell Death Signaling Process;Cell Nucleus;cell type;Cells;Cessation of life;Chiroptera;Clinical;clinically relevant;Cytoplasm;Cytotoxic T-Lymphocytes;Dedications;Disease;Elements;Evolution;Funding;Gene Expression;Genes;Genetic Polymorphism;Genetic Transcription;Genetic Variation;Goals;Host Defense;Human;Immunity;in vivo;Infection;Inflammation;Inflammatory;Influenza;Influenza A virus;influenza virus strain;influenzavirus;insight;Left;Ligands;Lung;Mediating;Modeling;Mus;Nature;Necrosis;Nuclear;Organism;Orthomyxoviridae;pandemic disease;pandemic potential;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Phosphotransferases;programs;Proteins;Public Health;Publishing;recruit;Reporting;RIPK3 gene;RNA;Role;Rupture;Seasons;sensor;Signal Transduction;Structure;Testing;Tissues;Viral;viral detection;Viral Pathogenesis;viral RNA;Virulent;Virus;Virus Diseases

PROJECT_TITLE: Mechanism, Function, and Exploitation of Influenza A Virus-Activated Cell Death


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Cardiovascular;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Heart Disease;Infectious Diseases;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Precision Medicine

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE COVID-19 is an ongoing global pandemic affecting millions of patients who survive but are at risk for developing ongoing cardiopulmonary symptoms. COVID-19 has been shown to be capable of causing cardiac injury, but long-term clinical consequences including duration of symptoms, effort tolerance, and prognosis are unknown. State-of-the-art cardiac MRI exams will be performed in a multiethnic New York City registry of COVID-19 survivors to address key knowledge gaps concerning clinical prognosis after infection which are critical to guide surveillance, risk stratification and targeted treatment for at risk COVID-19 survivors.

PI_NAMEs: KIM, JIWON  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: 3-Dimensional;Acute;acute COVID-19;acute infection;Address;adverse outcome;Affect;Arrhythmia;Biological Markers;Blood;Cardiac;cardiac magnetic resonance imaging;Cardiopulmonary;Chest Pain;Clinical;Clinical assessments;Clinical Data;clinical predictors;clinical prognosis;clinically relevant;common symptom;coronary fibrosis;COVID-19;COVID-19 impact;COVID-19 patient;COVID-19 risk;COVID-19 survivors;Data;data registry;Data Reporting;Dyspnea;Echocardiography;Edema;Event;Fatigue;Fibrosis;follow-up;Functional disorder;functional status;General Population;Heart;Heart failure;Heart Injuries;Heart Research;Histopathology;Hospitalization;Image;Impairment;improved;indexing;Infection;Inflammation;Knowledge;Left;Left Ventricular Dysfunction;Left Ventricular Remodeling;Longterm Follow-up;Lung;Lung Diseases;lung injury;Magnetic Resonance;Measures;Methods;mortality;mortality risk;multi-ethnic;Myocardial dysfunction;myocardial injury;Myocardial tissue;Myocardium;New York City;novel;Outcome;pandemic disease;Patients;Persons;Physiological;Population;Populations at Risk;predict clinical outcome;Predisposition;Prognosis;Property;Pulmonary Pathology;Quality of life;Recovery;Registries;Reporting;Research;Resolution;response;Right Ventricular Dysfunction;right ventricular remodeling;Risk;risk stratification;Specific qualifier value;stem;Structure;study population;Surveys;Survivors;Symptoms;targeted treatment;Technology;Testing;therapy development;Thrombosis;Time;tissue injury;Tissues;Treatment Failure;Uncertainty;United States;Ventricular;Viral;Walking

PROJECT_TITLE: Cardiac Magnetic Resonance for Tissue Characterization Based Risk Stratification of Cardiopulmonary Symptoms, Effort Tolerance, and Prognosis Among COVID-19 Survivors

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Cardiovascular;Congenital Structural Anomalies;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE This project will determine how sex as a biological variable impacts the progression of both aortic root aneurysm and coronary artery pathology in the context of the hereditary condition Marfan Syndrome. This work will identify how women may be resilient to aneurysm severity but more vulnerable to spontaneous coronary artery dissection events. Our findings will inform potential novel therapeutic targets and sex-specific strategies for both men and women with arterial disease.

PI_NAMEs: PARKER, SARAH J (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: acute coronary syndrome;Adhesions;Affect;Age;Aneurysm;Angiotensin II;Aorta;Aortic Aneurysm;arm;Arterial Disorder;Automobile Driving;Biological;Biology;Blood Vessels;Candidate Disease Gene;Case Study;causal variant;Cause of Death;Cell Lineage;Cell model;cell type;Cells;Collaborations;Complement;Core Facility;Coronary artery;Development;Diagnosis;Disease;Disease Management;Disease Progression;disorder prevention;Disparate;Disproportionately impacts women;Dissection;Estrogens;Event;Exhibits;experimental study;Exposure to;FBN1;Female;female sex hormone;Frequencies;Functional disorder;Gene Expression;Gene Mutation;Genes;Genetic Diseases;genome wide association study;Germ Cells;Gonadal Steroid Hormones;Heart;hormonal signals;Hormones;Human;human induced pluripotent stem cells;Image;improved;In Vitro;in vitro Model;in vivo;in vivo evaluation;induced pluripotent stem cell;Infusion procedures;Inherited;innovation;insight;Integrins;Knowledge;male;Marfan Syndrome;Mediating;men;Molecular;Molecular Profiling;mouse model;Mus;Mutation;Myocardial Infarction;new therapeutic target;novel strategies;Outcome;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Pattern;Phenotype;phosphoproteomics;Ploidies;Predisposition;Pregnancy;Prevalence;prevent;Prevention;Progesterone;Prognosis;protective pathway;Proteomics;receptor expression;Regulation;resilience;response;Risk;Risk Factors;Severities;sex;sex as a biological variable;Sex Bias;Sex Chromosomes;Sex Differences;Signal Transduction;single-cell RNA sequencing;Smooth Muscle;Smooth Muscle Myocytes;social;stem cell model;steroid hormone;Study models;subcutaneous;Techniques;Testing;Therapeutic;therapeutic target;Treatment outcome;Trees;United States;Validation;Woman;women's diagnosis;Women's study;Work;X Chromosome;young woman

PROJECT_TITLE: Mechanisms of sex-biased risk and resiliency in aneurysm and dissection


ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Type 2 diabetes and related metabolic diseases are leading causes of morbidity and mortality worldwide. Traits related to these diseases have a strong inherited basis, and the proposed work will identify the genes and DNA variations that influence diabetes and determine how the DNA variants influence gene function. Results may identify new targets for drugs and lead to improved prediction of disease.

PI_NAMEs: MOHLKE, KAREN L. (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Acceleration;Achievement;Address;Affect;Alleles;Amino Acids;B-Lymphocytes;Binding;Biological;Biological Assay;Blood;Candidate Disease Gene;candidate identification;Cell Physiology;cell type;Chromatin;Clinical;Clinical Data;Cluster Analysis;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Data;data sharing;Development;Diabetes Mellitus;diabetes mellitus genetics;diabetes pathogenesis;diabetes risk;Disease;DNA;Enhancers;exome;Functional disorder;gene environment interaction;Gene Expression Regulation;gene function;Genes;genetic analysis;Genetic Transcription;genetic variant;Genome;genome editing;genome wide association study;genomic locus;Genotype;Goals;Grant;Impairment;improved;Individual;Inflammation;Inherited;insight;Insulin;Insulin Resistance;insulin secretion;islet;Islets of Langerhans;Life Style;Link;lipid metabolism;Lipids;Liver;Maps;Meta-Analysis;Metabolic Diseases;Methods;Molecular;Morbidity - disease rate;mortality;Multiomic Data;multiple omics;new technology;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nucleotides;Obesity;Pathologic;Pathway interactions;Peripheral;Pharmacologic Substance;Predisposition;prevent;prime editing;Process;Productivity;Proinsulin;Public Health;Quantitative Trait Loci;Regulation;Regulator Genes;Reporter;Research Personnel;Risk;risk variant;Sampling;Signal Transduction;success;therapeutic target;Tissues;trait;Transcriptional Regulation;transcriptomics;Translating;Transposase;Untranslated RNA;Variant;web portal;Work

PROJECT_TITLE: Targeted Genetic Analysis of T2D and Quantitative Traits

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: As the US population is aging, the number of persons affected by multiple chronic diseases is increasing. There is an urgent need for countering this challenge. The proposed study will examine immune cells in humans, which can help us to develop anti-inflammatory therapy for preventing multiple diseases simultaneously.

PI_NAMEs: DING, JINGZHONG  (contact);KRITCHEVSKY, STEPHEN B.;LIU, YONGMEI

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Acceleration;Adipose tissue;Affect;Aging;aging related disease;Alzheimer's Disease;Animals;Anti-Inflammatory Agents;Autoimmune;Biological Markers;Cardiovascular Diseases;cardiovascular disorder risk;Cell Differentiation process;Cells;Chronic;Chronic Disease;circulating biomarkers;Circulation;Clinical;CREB1 gene;Cryopreservation;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;cyclooxygenase 1;cytokine;Data;Development;Diabetes Mellitus;Dinoprostone;Disease;experimental study;follow-up;Genes;Helper-Inducer T-Lymphocyte;Human;IgG Receptors;IL17 gene;IL6 gene;Immune;immune cell infiltrate;Immune response;Immune system;improved;In Vitro;indexing;Individual;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Interleukin-1 beta;Intervention;Literature;Longitudinal Studies;Macrophage;Malignant Neoplasms;Mediating;Micro Array Data;Microarray Analysis;monocyte;mouse model;Multi-Ethnic Study of Atherosclerosis;multiple chronic conditions;Mutation;older adult;Organism;Osteoporosis;Participant;Pathology;Pathway interactions;Peripheral;Persons;pharmacologic;Phenotype;Play;polarized cell;Population;prevent;Process;Production;Prostaglandin-Endoperoxide Synthase;Prostaglandins;PTGS2 gene;receptor;Regulation;Resources;Risk;Risk Reduction;Role;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specificity;targeted treatment;Testing;Time;Tissues;Transcript;transcriptome sequencing;Translations;Work

PROJECT_TITLE: T helper cells in development of chronic inflammation and multimorbidity

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: HADLEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PUBLIC HEALTH NARRATIVE A fundamental challenge for the scientific community in the 21st century is learning how to turn data into evidence that can inform decision-making about improving health and preventing illness at the individual and population levels. Real-time infectious disease forecasting is a prime example of a field with great potential for leveraging modern analytical methods to maximize the impact on public health. The goal of the proposed research is to develop statistical modeling frameworks and pipelines for making forecasts of infectious diseases in real-time and integrating these forecasts into public health decision making.

PI_NAMEs: REICH, NICHOLAS G (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: analytical method;Area;Collection;Communicable Diseases;Communities;Data;Decision Making;Disease Outbreaks;Evaluation;global health;Goals;Health;Healthcare;improved;Individual;infectious disease model;Intervention;Learning;Learning Module;Methodology;Methods;Modernization;open source;Population;prevent;Prevention strategy;Public Health;Research;Research Activity;Research Personnel;Series;Statistical Models;Time;Training;Vaccine Design;vaccine trial

PROJECT_TITLE: Methods for real-time forecasting and inference during infectious disease outbreaks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE Deficiencies in peroxisomes have been associated with a variety of disease states, including inherited neuropathologies, aging, heart disease, cancer, and diabetes. Experiments outlined in this proposal seek to elucidate the importance of UBXD8 in maintaining peroxisome homeostasis and the subsequent impact on cellular pathways involved in the development of lipid metabolic diseases. Results from this proposal will inform novel molecular mechanisms by which peroxisome abundance is regulated thus bringing us closer to potential therapeutic targets for treating lipid metabolic diseases.

PI_NAMEs: MONTES, IRIS  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Adaptor Signaling Protein;Adipocytes;Aging;ATP phosphohydrolase;Autophagocytosis;Bile Acids;Biochemical;Biogenesis;Biological Assay;career;Catabolism;Cell Line;cell type;Cells;cellular targeting;Cholesterol;Confocal Microscopy;Development;Diabetes Mellitus;Disease;early childhood;Endoplasmic Reticulum;Enzymes;Eukaryotic Cell;experience;experimental study;Exposure to;Fatty Acids;Feedback;Future;Heart Diseases;Homeostasis;Hydrolysis;Image;Inherited;Knock-out;Knockout Mice;Knowledge;Life Cycle Stages;lipid biosynthesis;lipid mediator;lipid metabolism;lipidomics;Lipids;Malignant Neoplasms;Mammalian Cell;Measures;Mediating;Metabolic;Metabolic Diseases;Microscopy;Microsomes;Molecular;neuropathology;novel;Null Lymphocytes;Organelles;oxidation;Pathology;Pathway interactions;Patients;peroxisome;Phenotype;Phospholipid Ethers;Physiologic pulse;Plasma;Play;Positioning Attribute;Process;Proteins;Proteome;Proteomics;Purines;Qualifying;Quality Control;Research Personnel;Role;sensor;Signal Pathway;Site;species difference;sterol ester;sterol homeostasis;System;Techniques;Testing;therapeutic target;Ubiquitin;Very Long Chain Fatty Acid;Vesicle;Work;Yeasts

PROJECT_TITLE: Determining the Role of p97 Adaptor UBXD8 in Peroxisome Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE The proposed research is key to identifying the mechanisms that contribute to cancer-related disparities and to improving the care of limited English proficient patients across the cancer care continuum. The findings from this study will have implications for patients, health care providers and administrators, and policy makers with potential for a pivotal change in thyroid nodule and thyroid cancer management.

PI_NAMEs: CHEN, DEBBIE WAN HUA (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;advanced disease;Area;arm;Asian;Asian Americans;Asian population;Asian Women;barrier to care;burden of illness;California;cancer care;cancer diagnosis;cancer health disparity;Cancer Patient;cancer therapy;care delivery;Caring;Cause of Death;Cessation of life;Chinese;Chinese American;Chinese population;Clinical Trials;Cohort Studies;Communication;Continuity of Patient Care;Data;Death Rate;Decision Making;design;Detection;Development;Diagnosis;Disparity;Effectiveness of Interventions;English Language;Equity;ethnic minority population;Ethnic Origin;Ethnic Population;Evaluation;experience;Fine needle aspiration biopsy;Focus Groups;Funding;Goals;Health Personnel;Health Services;improved;Individual;Information Resources;innovation;International;Intervention;K-Series Research Career Programs;Language;Learning;Limited English Proficiency;Linguistics;Link;Literature;Malignant neoplasm of thyroid;Malignant Neoplasms;Medical;Mentors;Michigan;Modeling;mortality;Nodule;nonEnglish language;Outcome;Pacific Islander;patient population;Patient Recruitments;Patient Self-Report;Patients;Physicians;Pilot Projects;Policy Maker;Population;Preparation;prototype;Public Health;Quality of Care;Race;racial population;recruit;Reporting;Research;Research Personnel;Research Proposals;Resources;Sampling;San Francisco;sex;Site;skill acquisition;Surgical complication;Surveys;therapy development;Thyroid Gland;Thyroid Nodule;tool;Training;United States;Universities;Variant;virtual;Work

PROJECT_TITLE: A Paradigm to Examine Cancer Disparities: Limited English Proficient Chinese Patients with Thyroid Nodules

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Prevention;Primary Health Care

PHR: Project Narrative Improved methods for early detection of colon cancer may be achieved by detecting imaging biomarkers that are unique to cancer. Early disease that is either flat or subtle in appearance can be easily missed with conventional colonoscopy. Improved visualization can be achieved by developing protein fragments that bind to biomarkers that arise from separate biological pathways.

PI_NAMEs: WANG, THOMAS D (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;adenoma;Affinity;Antibodies;Appearance;Area;authority;Binding;Biochemical;Biological;Biological Assay;Biological Markers;Biopsy;Cancer Etiology;Cell surface;Cells;Cessation of life;Clinic;Clinical;Clinical Research;clinically relevant;Colon;colon cancer screening;Colonoscopy;Colorectal Cancer;colorectal cancer screening;Community Physician;contrast imaging;Contrast Media;design;Detection;detection sensitivity;Development;Devices;Dimensions;Disease;DNA;Early Diagnosis;Effectiveness;Endoscopes;Endoscopy;Excision;Fecal occult blood;Fiber;flexibility;Fluorescence;fluorescence imaging;fluorophore;Genetic Heterogeneity;Heterogeneity;hexanoic acid;Human;human subject;Image;imaging agent;imaging biomarker;imaging detection;Imaging Device;imaging modality;Immunocompromised Host;Implant;improved;In Vitro;in vivo;in vivo imaging;instrument;Kinetics;Label;Lesion;Ligands;Light;Lighting;Localized Lesion;Malignant Neoplasms;Medical;Methods;MicroRNAs;microsystems;minimally invasive;Molecular;Molecular Target;monomer;Mucous Membrane;Mus;Optics;Organ;Organoids;overexpression;Pathway interactions;patient population;Patients;Peptides;Performance;peroxiredoxin I;Physicians;Pre-Clinical Model;premalignant;prevent;Primary Care Physician;Procedures;Protein Fragment;Proteins;prototype;Recommendation;Resected;Resolution;response;routine imaging;Scanning;Screening for cancer;Serrated Adenoma;Specificity;Specimen;Structure;Surface;targeted imaging;Technology;Testing;tumor progression;Validation;Visualization;Work

PROJECT_TITLE: Early detection of colorectal cancer in the traditional and serrated pathways


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Human Genome;Rare Diseases

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Succinate dehydrogenase is a mitochondrial complex with critical roles in metabolism and. Inherited loss-of- function variants in the succinate dehydrogenase genes are causative in several human cancers, and tumors have been linked to DNA damage. This proposal aims to accurately characterize the phenotypes and tumor biology associated with succinate dehydrogenase germline pathogenic variants, to develop improved risk estimates and evaluate potential targeted therapies for patients who progress to disease.

PI_NAMEs: WACHTEL, HEATHER  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Advisory Committees;Alleles;biobank;Bioinformatics;Biological Assay;Biological Markers;career;career development;causal variant;Cell Line;Cells;Cicatrix;Citric Acid Cycle;Clinical;Clinical Data;Clinical Trials;cohort;Complex;Correlative Study;Data;Development;Development Plans;Disease;DNA Damage;DNA Repair;DNA Repair Disorder;enzyme deficiency;exome sequencing;experience;experimental study;Five-Year Plans;Future;gastrointestinal;Genes;genetic variant;genomic data;Genomic DNA;genomic signature;Genomics;Genotype;Germ Lines;Germ-Line Mutation;Goals;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;Histologic;homologous recombination;Human;human disease;Immunologics;improved;Inflammation;Inflammatory;Inherited;inhibitor;inhibitor therapy;Institution;K-Series Research Career Programs;Knowledge;Lead;Link;loss of function;loss of function mutation;Malignant Neoplasms;Medicine;Mentors;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Mitochondria;mutant;Mutate;Mutation;neoplastic cell;Neuroendocrine Tumors;new therapeutic target;novel;novel strategies;Oxidative Phosphorylation;Paraganglioma;Participant;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pennsylvania;phenome;Phenotype;Pheochromocytoma;Physicians;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Polymerase;Population;pre-clinical;predicting response;Prediction of Response to Therapy;Predisposition;prognostication;Program Development;Proteins;radiotracer;Renal Cell Carcinoma;repository;Research;Research Personnel;Resources;response;Risk;Risk Estimate;Role;Scientist;Signal Transduction;skills;Specimen;Stromal Cells;Succinate Dehydrogenase;Succinates;Susceptibility Gene;targeted treatment;The Cancer Genome Atlas;Therapeutic;tool;Training;Transducers;translational approach;tumor;Tumor Biology;tumorigenesis;Universities;Variant;Work

PROJECT_TITLE: A genotype-phenotype study of germline succinate dehydrogenase pathogenic variants