NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Behavioral and Social Science;Breast Cancer;Cachexia;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Skin Cancer;Social Determinants of Health;Women's Health Research

PI_NAMEs: WINTERS-STONE, KERRI M (contact)

PROJECT_TERMS: Acceleration;Accounting;Address;Adoption;Advanced Malignant Neoplasm;Aging;Alaska Native;American Indians;Animal Cancer Model;anti-cancer research;Area;Biology;Cancer Biology;Cancer Burden;Cancer Cachexia;cancer care;Cancer Control;Cancer Control Research;Cancer Control Research Program;cancer epidemiology;cancer prevention;cancer risk;Cancer Survivor;cancer therapy;Caring;Catchment Area;Cause of Death;Cessation of life;Chemoprevention;Clinical Medicine;clinical practice;Clinical Trials;cohort;Collaborations;Colon Carcinoma;Communities;community engaged research;Decision Making;design;Development;Direct Costs;Discipline;Disease;Disease Progression;Doctor of Philosophy;Early Diagnosis;Early identification;early screening;efficacy/implementation trial;end of life;end of life care;Epidemiology;Equity;Evaluation;evidence base;Exercise;Fostering;Funding;Future;Genetic Diseases;Genetic Risk;Genetic Screening;Goals;graduate student;Grant;Health Promotion;Health Services Research;Healthcare;Hereditary Nonpolyposis Colorectal Neoplasms;Heritability;high risk population;implementation science;improved;Incidence;Inequity;Infrastructure;innovation;Institute for Cancer Prevention;inter-institutional;Interdisciplinary Study;Intervention;Intervention Studies;Journals;Knowledge;Lead;Leadership;Life;Low income;Low Income Population;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Melanoma;member;Mentorship;Morbidity - disease rate;mortality;Neighborhood Health Center;Neuroendocrinology;novel;older adult;older patient;Oregon;Outcome;Patient Care;patient oriented;Peer Review;personalized screening;Population;population based;population health;Populations at Risk;preclinical trial;Predisposition;prevent;Prevention;Prevention education;Prevention Research;preventive intervention;programs;Provider;Public Health;Publications;Quality of life;Recommendation;Research;Research Design;Research Personnel;Risk;Risk Factors;Risk Reduction;risk stratification;Rural;Science;Scientist;screening;Screening for cancer;screening guidelines;screening services;Series;Strategic Planning;survivorship;targeted treatment;Technology;Testing;Therapeutic Agents;therapy development;Time;tool;Training Programs;Translating;translational research program;Treatment-Related Cancer;tribal community;Underrepresented Minority;Update;uptake;Veterans;Vulnerable Populations;War;Work;young woman

PROJECT_TITLE: Cancer Prevention and Control Research Program


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Obesity;Prevention;Sleep Research

ORG_CITY: CLEVELAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This study is relevant to public health because it will help researchers design studies of targeted approaches to treatment of obstructive sleep apnea and obesity. The findings will guide the development of future drugs and devices for obstructive sleep apnea. Such results will have a positive impact on future diagnostics and interventions, and permit select interventions early on in the progression of all three disorders, thereby reducing cost and preventing adverse cardiovascular outcomes.

PI_NAMEs: NEELAND, IAN JASON (contact);YAGGI, HENRY KLAR

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Abdomen;actigraphy;Adipose tissue;Adult;adult obesity;Age;anatomic imaging;Anatomy;Apnea;Arousal;Back;bench to bedside;Biological Markers;Blood;Body mass index;Body Weight decreased;Caliber;Cardiovascular system;Clinical;Clinical Trials;Continuous Positive Airway Pressure;cost;cost estimate;Data;Deposition;Development;Devices;Diagnosis;Diagnostic;Disease;Diuresis;Early Intervention;efficacy testing;Equilibrium;Ethnic Origin;Fatty acid glycerol esters;Fluid Shifts;Functional disorder;Future;Glucose;Goals;Health;Heart failure;Hyperglycemia;Hypertension;Hypoxia;Image;Impairment;improved;indexing;Individual;insight;Intervention;Kidney;Knowledge;Measurable;Measures;Mediating;Mediation;Medical;Mental Depression;Metabolic;Monitor;Morbidity - disease rate;mortality;Muscle;Myocardial Infarction;Neck;Neurocognitive;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Obstructive Sleep Apnea;Outcome;Overweight;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;pharyngeal critical pressure;pharynx muscle;phase III trial;Phenotype;Physiological;Physiology;Placebos;Plasma;Polysomnography;pressure;prevent;Prevention;prospective;Prospective Studies;Public Health;Quality of life;Race;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Research;Research Design;Research Personnel;Risk;Role;Severities;sex as a biological variable;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Fragmentations;Sodium;Stroke;Structure;Surveys;symporter;Techniques;therapeutic target;Tissues;Tongue;trait;Translating;vehicular accident;Viscera;Visceral;wearable device;Wrist

PROJECT_TITLE: Adipose Dysfunction, Imaging, Physiology, and Outcomes with SGLT2i's for Sleep Apnea: The ADIPOSA Study

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PI_NAMEs: TEUNISSEN, ABRAHAM  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TITLE: Biomedical Engineering Core


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: SHANNON, JACKILEN  (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;Attention;Basic Science;Behavior;Breast;Cancer Biology;Cancer Burden;Cancer Center;cancer education;cancer health disparity;cancer prevention;Catchment Area;Clinical;Clinical and Translational Science Awards;Clinical Research;cohort;Collaborations;Colorectal;Communication;Communities;community advisory board;community engaged research;community engagement;Community Hospitals;community organizations;Community Outreach;community partnership;County;Data Collection;data resource;Dedications;disease registry;Disparity;Doctor of Medicine;Doctor of Philosophy;Early Diagnosis;Ensure;ethnic disparity;Ethnic Origin;farmer;frontier;Funding;Genetic Screening;geographic disparity;Geography;Grant;High Prevalence;Human Papilloma Virus Vaccination;innovation;Investments;Leadership;leukemia/lymphoma;low dose computed tomography;Lung;lung cancer screening;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Master of Public Health;Melanoma;Migrant Workers;Modeling;mortality;Names;NCI-Designated Cancer Center;Oncology;Oregon;outreach;Poison;Population;population based;Prevention program;Process;programs;Prostate;Race;racial disparity;Recording of previous events;recruit;Reporting;Research;Research Assistant;Research Institute;Research Personnel;Rural;Scientist;Screening for cancer;screening program;success;survivorship;Tobacco use;Tobacco Use Cessation;Training;translational oncology;Translational Research;Trust;Underrepresented Populations;Vision;Work

PROJECT_TITLE: Community Outreach and Engagement

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Heart Disease;Mental Health;Neurosciences

PI_NAMEs: SWIRSKI, FILIP K (contact)

PROJECT_TERMS: acute stress;Adverse effects;Affect;arm;Arterial Fatty Streak;Atherosclerosis;Attention;Body System;Bone Marrow;Brain;Brain region;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Cell Count;Cell Nucleus;cell type;Cells;Central Nervous System;Chronic;Clinical;Communication;conditioning;Data;Development;Disease;Epigenetic Process;Exhibits;Funding;Genetic;Glucocorticoid Receptor;Health;Hematopoiesis;Immune;Immune system;Immunology;Impairment;imprint;Individual;Inflammation;Knockout Mice;Knowledge;Leukocytes;Link;Lipids;Lymphocyte Function;Lymphoid Cell;Macrophage;migration;Modeling;Molecular;monocyte;mouse model;Mus;Myeloid Cells;Nervous System;Nervous System Physiology;Neuroimmune;neurovascular;neutrophil;optogenetics;Organ;Pathway interactions;perceived stress;Peripheral;Peripheral Nervous System;pharmacologic;Predisposition;Process;Psychosocial Stress;Publishing;Refractory;resilience;Resolution;response;Risk;Shapes;social defeat;social stress;Spatial Distribution;Stress;stress resilience;Sympathetic Nervous System;Techniques;Testing;Tissues;tool;trafficking;transcriptome;treatment response;Vascular System;Viral

PROJECT_TITLE: Stress perception and cardiovascular immunology


NIH_SPENDING_CATS: Cancer

PI_NAMEs: ROBERTS, MINDY  (contact)

PROJECT_TERMS: Area;Award;Behavior;Cancer Biology;Cancer Center Support Grant;Cancer Control;cancer prevention;Collaborations;community engagement;Community Outreach;Data;Development;Equipment;Faculty;Funding;Generations;Institution;Investments;Malignant Neoplasms;member;Oncology;Peer Review;Pilot Projects;programs;Publications;recruit;Reporting;Research;Research Institute;Research Personnel;Resource Sharing;Scientist;Services;Shapes;Strategic Planning;success;Training and Education;translational oncology;Vision

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Complementary and Integrative Health;Digestive Diseases;Networking and Information Technology R&D (NITRD);Opioids;Pain Research;Palliative Care;Rehabilitation

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE Patients with malignancy of the digestive tract often experience severe and unremitting abdominal pain that negatively affects physical, emotional, and social function. Patients frequently turn to opioids when other treatments fail to provide adequate analgesia, yet often discover that opioids also fall short in delivering meaningful pain reduction or improving quality of life. This study will test the impact of therapeutic virtual reality (VR)—an evidence-based treatment for pain—as a non-pharmacologic adjunctive treatment for cancer-related pain in patients with malignancies of the digestive tract.

PI_NAMEs: IRWIN, SCOTT A;SPIEGEL, BRENNAN  (contact)

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: 3D world;Abdominal Pain;Absence of pain sensation;Acute Pain;Address;Affect;Biofeedback;Biometry;biopsychosocial;Brain;Breathing Exercises;cancer clinical trial;cancer diagnosis;Cancer Etiology;cancer pain;Cancer Pain Management;Cessation of life;chronic musculoskeletal pain;chronic pain;Clinical;clinically significant;Cognitive Therapy;Colorectal;comorbidity;comparative effectiveness study;Complex;Control Groups;cost;cybersickness;Devices;distraction;Educational process of instructing;emotional functioning;Enrollment;Esophagus;Esthesia;Evidence based treatment;experience;Eye;Functional Magnetic Resonance Imaging;functional status;Funding;Gastrointestinal tract structure;Goggles;Harm Reduction;health related quality of life;healthy volunteer;Helping to End Addiction Long-term;Hepatobiliary;High Performance Computing;Home;Hospitalization;Hydromorphone;Impairment;improved;Intervention;Intestines;Life;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Meditation;mindfulness;Modality;Morbidity - disease rate;mortality;Musculoskeletal Pain;Nausea;Opioid;Opioid Analgesics;opioid use;Outcome;Pain;pain catastrophizing;Pain management;Pain Measurement;pain reduction;pain relief;pain score;Pancreas;Patient Outcomes Assessments;Patient Selection;patient subsets;Patients;Persons;Photic Stimulation;Physical Function;post intervention;prescription opioid;primary outcome;Quality of life;Randomized;Randomized, Controlled Trials;Research;Risk;risk minimization;satisfaction;secondary outcome;Self Efficacy;Sensory;skills;Social Functioning;Social support;sociodemographic factors;Stimulus;Study Skills;Technology;Testing;theories;Therapeutic;Treatment Efficacy;treatment response;Treatment-Related Cancer;United States National Institutes of Health;virtual reality;virtual reality environment;virtual reality headset;Visceral;Visceral pain;Visual Cortex;Work

PROJECT_TITLE: Randomized Controlled Trial of Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

PHR: NARRATIVE Idiopathic pulmonary fibrosis is a deadly progressive disease without curative therapy. Because we found that syndecan-1 augmented lung fibrosis through miRNAs in extracellular vesicles (EVs), we propose to investigate how syndecan-1 regulates miRNA packaging into EVs to control fibroproliferation. The findings of the study will provide a novel knowledge that can potentially lead to new therapeutic options for this deadly disease. 8.

PI_NAMEs: PARIMON, TANYALAK  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: 3-Dimensional;Advisory Committees;alveolar epithelium;Area;Attenuated;Biogenesis;Biology;Bleomycin;career development;Cell Aging;Cell Communication;Cell surface;cell type;Cells;cellular targeting;chemokine;Complex;coronary fibrosis;curative treatments;Data;Deposition;Disease;Doctor of Medicine;Doctor of Philosophy;Educational workshop;Endosomes;Epithelial Cells;Epithelium;Extracellular Matrix;extracellular vesicles;Fibroblasts;Fibrosis;Goals;Growth Factor;Heparan Sulfate Proteoglycan;Homeostasis;Human;idiopathic pulmonary fibrosis;In Vitro;in vivo;Incidence;injured;injury and repair;Investigation;K-Series Research Career Programs;Knowledge;Laboratories;Learning;lectures;Ligand Binding;Liver Fibrosis;Los Angeles;Lung;Lung Diseases;Lung fibrogenesis;lung injury;lung repair;Lysosomes;Malignant neoplasm of lung;Mediating;Membrane;Membrane Microdomains;Mentors;MicroRNAs;Mus;novel;novel therapeutic intervention;novel therapeutics;Organoids;overexpression;Pathogenesis;Pathway interactions;Phenotype;Physicians;Play;Process;Profibrotic signal;programs;Progressive Disease;Proteins;Proteoglycan;Pulmonary Fibrosis;receptor;Regulation;Reporting;Research;Research Personnel;Research Proposals;respiratory;response;Role;Scientist;senescence;Shapes;Signal Pathway;skills;Sorting;Stimulus;symposium;syndecan;System;Testing;trafficking;Training;Training Programs;Transforming Growth Factor beta;Translational Research;Type II Epithelial Receptor Cell;Vocational Guidance;Wild Type Mouse

PROJECT_TITLE: Syndecan-1 regulation of lung fibrosis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


PI_NAMEs: HARRINGTON, CHRISTINA  (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;Basic Science;Biological Assay;biomedical data science;Biomedical Research;Biometry;Cancer Patient;Clinical;Clinical Research;Collaborations;Communication;Communities;cost effective;cost effectiveness;Data Science;Development;Digital biomarker;digital technology;Doctor of Philosophy;Early Diagnosis;Emerging Technologies;Ensure;Evaluation;Flow Cytometry;Flow Cytometry Shared Resource;Funding;Future;Genomics;Goals;Guidelines;health data;Immune;Immunologic Monitoring;instrument;Investments;Leadership;Malignant Neoplasms;meetings;member;Microscopy;Monitor;new technology;operation;Outcomes Research;Pathology;Performance;Policies;precision oncology;Procedures;programs;Proteomics;Recommendation;Reproducibility;Research;Research Institute;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Sampling;satisfaction;service delivery;Services;Strategic Planning;success;Surveys;System;Technology;Translational Research;translational study;treatment response;Universities;Work;working group

PROJECT_TITLE: Shared Resource Management


NIH_SPENDING_CATS: Cancer;Precision Medicine

PI_NAMEs: DRUKER, BRIAN J (contact)

PROJECT_TERMS: anti-cancer research;Area;Basic Science;Beer;Biophysics;Cancer Biology;Catchment Area;Clinic;Clinical;Clinical Research;Communities;community advisory board;community engagement;Community Outreach;Doctor of Medicine;Doctor of Philosophy;Early Diagnosis;Ensure;equity, diversity, and inclusion;Evaluation;Event;Fostering;Genetic;Goals;Growth and Development function;innovation;Institution;Leadership;Malignant Neoplasms;Master of Public Health;member;Molecular Target;Oncology;operation;Oregon;Policies;Population Sciences;precision medicine;precision oncology;recruit;Research;Research Training;Resource Sharing;Resources;Scientific Advances and Accomplishments;Strategic Planning;Strategic vision;Training and Education;training opportunity;Translational Research;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

PI_NAMEs: KUMMAR, SHIVAANI  (contact)

PROJECT_TERMS: Adult;Age;Age Years;Budgets;cancer clinical trial;Cancer Patient;Career Choice;Catchment Area;clinical care;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;Communities;Complex;Conduct Clinical Trials;Consultations;Contracts;COVID-19 pandemic;Custom;Data;Data Collection;data infrastructure;data management;Databases;Dedications;design;Development;Doctor of Medicine;Education;Effectiveness;electronic data;Elements;Ethnic Origin;Gender Identity;Geographic Locations;Goals;Good Clinical Practice;Growth;human old age (65+);Immigration;improved;Individual;Industry Collaboration;Infrastructure;innovation;Intervention;Intervention Trial;investigator-initiated trial;Investments;Language;Malignant Neoplasms;Master of Business Administration;Master of Public Health;Mediation;member;Monitor;Monitoring Clinical Trials;National Clinical Trials Network;novel;Nursing Research;Oregon;Patients;Physician Executives;Population;Process;process improvement;Protocols documentation;Provider;Race;Research;Research Personnel;rural area;Safety;Services;Sex Orientation;Training and Education;Training Programs;Translational Research;treatment trial;trial comparing;Underrepresented Populations;Writing

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Aging;Atherosclerosis;Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Mental Health;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: MULDER, WILLEM  (contact)

PROJECT_TERMS: Arteriogram;Atherosclerosis;biobank;Biological Assay;Bone Marrow;Bone Marrow Aspiration;Bone Marrow Transplantation;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Catecholamines;Cell Compartmentation;Cell Reprogramming;Cells;Chronic;Chronic stress;clinical imaging;clinical translation;cohort;Coronary Arteriosclerosis;Coronary artery;Development;Disease;Epigenetic Process;Event;experience;Exposure to;Familial Hypercholesterolemia;fluorodeoxyglucose positron emission tomography;Glucocorticoids;Heart failure;Hematopoietic;Hematopoietic stem cells;high risk;hormonal signals;Hormones;Human;human model;Image;Immune;immune imaging;Immunity;Immunologic Memory;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Innate Immune System;insight;Intervention;Ligation;Metabolic;Methods;Modification;monocyte;mouse model;Multiomic Data;multiple omics;Mus;Myelogenous;Myeloid Cells;Myelopoiesis;Myocardial Infarction;nanobiologic;optogenetics;Outcome;oxidized low density lipoprotein;Patients;perceived stress;Peripheral;Phenotype;Pheochromocytoma;Positron-Emission Tomography;profiles in patients;progenitor;programs;Psychosocial Stress;Questionnaires;recruit;Reporting;Rest;Risk Factors;Sampling;stem cells;Sterility;Stimulus;Stress;System;Testing;Therapeutic;Training;Vaccination;Work

PROJECT_TITLE: Stress-induced trained immunity in cardiovascular disease


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative The cerebellum, a brain region implicated in fine-tuning of movements, also influences social interaction and updating of cognitive states such as reward and working memory. Cerebellar injury in humans and other animals leads to pronounced social and cognitive deficits, especially when it occurs early in life. The proposed studies will uncover how neural activity in the cerebellum modulates cognitive task performance in mice and thus contribute to understanding of syndromes marked by cerebellar dysfunction, including attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and autism spectrum disorder.

PI_NAMEs: WANG, SAMUEL SHENG-HUNG (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Adaptive Behaviors;Affect;Affective;Anatomy;Animal Experimentation;Animals;Anterior;Area;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavior Control;Brain;Brain region;Calcium;Cells;Cerebellar Diseases;Cerebellum;Clinical;Code;Cognition;Cognitive;Cognitive deficits;cognitive task;Complex;Computer Models;Data;Decision Making;density;Dependence;Electrodes;Evolution;executive function;experimental study;flexibility;Foundations;Goals;granule cell;Human;Image;Impairment;Injury;Laboratories;Learning;Life;Link;Measures;Midbrain structure;Monitor;Motor;Motor output;Movement;Mus;Neocortex;neural;Neurons;Neurosciences;Nuclear;Obsessive-Compulsive Disorder;optogenetics;Output;Pathway interactions;predictive modeling;Preparation;Process;Property;Prosencephalon;Purkinje Cells;Ramp;Resolution;response;Rewards;Role;Sensory;sensory input;sensory integration;Shapes;Short-Term Memory;Signal Transduction;Silicon;social cognition;social deficits;social influence;Social Interaction;Synapses;Syndrome;System;Task Performances;Testing;Thalamic structure;Time;tool;Training;two-photon;Update;Viral;Work

PROJECT_TITLE: Adaptive Cerebellar Processing at Cellular Resolution in Flexible Behavior

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


PROJECT_TERMS: authority;Biometry;Cancer Patient;Clinical Research;clinical trial protocol;Clinical Trials;Data;design;Development;Disease;Doctor of Medicine;Eligibility Determination;Enrollment;Ensure;Evaluation;Goals;Guidelines;Human Resources;improved;Institutional Review Boards;Malignant Neoplasms;Monitor;patient population;Peer Review;pharmacologic;Population;Process;Protocols documentation;Research;Resources;Safety;Site;sound;Specific qualifier value;Support System;System;Translational Research

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Using a mixed methods 2X2 factorial design, we will conduct a multi-level intervention randomized trial in four health systems to test the combined and separate effects of primary care provider support and patient outreach on shared decision making and lung cancer screening.

PI_NAMEs: MYERS, RONALD E. (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Address;Adoption;Adult;Affect;Age Years;aged;Baseline Surveys;Cancer Etiology;Caring;Cessation of life;cohort;Communication;Computerized Medical Record;Consent;Control Groups;Country;Data;Death Rate;Delaware;design;Eligibility Determination;Focus Groups;Guidelines;Health;Health Professional;Health system;Healthcare Systems;implementation intervention;Information Systems;Intervention;intervention effect;Interview;Journals;low dose computed tomography;lung cancer screening;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Mediator;meetings;Methods;mortality;Participant;patient level intervention;patient outreach;Patients;Peer Review;Pennsylvania;Physicians;Primary Care;primary care practice;primary care provider;primary care visit;Professional Organizations;Provider;Publications;Randomized;randomized trial;Recommendation;recruit;Reporting;Schedule;screening;shared decision making;Site;Smoke;Smoking History;Support Groups;Surveys;symposium;Telephone;Testing;United States;United States Centers for Medicare and Medicaid Services;United States Preventative Services Task Force;Update

PROJECT_TITLE: Provider Support and Patient Outreach in Lung Cancer Screening

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Neurosciences;Prevention

PI_NAMEs: FAYAD, ZAHI A. (contact)

PROJECT_TERMS: Acute;Alcohol consumption;Amygdaloid structure;Atherosclerosis;Blood;Blood Flow Cytometry;Brain;brain circuitry;Brain region;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular Manifestation;Cardiovascular Physiology;Cardiovascular system;Chronic;Chronic stress;coronary fibrosis;Data;Diffusion Magnetic Resonance Imaging;Disease;Elements;Exercise;experience;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Functional Magnetic Resonance Imaging;Genetic;Genetic study;Grant;Health behavior;Heart;high risk;Human;Hypertension;Immune;immune function;Immune system;immunoregulation;Impairment;improved;Individual;Inflammation;insight;Insulin Resistance;Knowledge;Lead;Leukopoiesis;lifestyle factors;Link;Magnetic Resonance Imaging;Measures;Mediating;multimodality;multiple omics;neural;neural network;Neurobiology;Neuroimmune;Neurologic;Neurophysiology - biologic function;non-invasive imaging;novel strategies;Obesity;Patients;Peripheral;peripheral blood;Persons;Population;Positron-Emission Tomography;Post-Traumatic Stress Disorders;Prefrontal Cortex;Process;programs;promoter;Proteomics;Psychosocial Stress;Resolution;Risk;Risk Factors;Sleep;Smoking;Stress;System;systemic inflammatory response;tool;trait;transcriptomics;Visceral

PROJECT_TITLE: Multimodal profiling of stress-induced immune reprogramming in cardiovascular patients


ADMINISTERING_IC: NR

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Narrative Health information technology tools such as secure messaging and diabetes apps have tremendous potential to decrease barriers to care and promote self-management for Type 2 Diabetes (T2D). This study will develop a method to leverage such tools for helping low socioeconomic status patients manage T2D through improved individualized education, problem-solving help, and remote monitoring by clinicians. Findings from this study have the potential to improve virtual diabetes care and outcomes for low socioeconomic status populations.

PI_NAMEs: CHEN, HELEN NAI-CHI (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Address;Area;Award;barrier to care;Behavior;Behavior Therapy;biomedical informatics;Blood Glucose;Care given by nurses;career;Caring;Cellular Phone;Characteristics;Chronic Disease;Clinic;Clinical;Collaborations;Complex;Coping Skills;Cultural Sensitivity;Data;data exchange;design;Development;diabetes educator;Diabetes Mellitus;Diet;Disease;Disease Management;Documentation;Education;Educational Materials;Educational Technology;effectiveness evaluation;effectiveness testing;Electronic Health Record;Electronics;Environment;Evaluation;Event;Evidence based intervention;Exercise;experience;Face;Failure;family management;Feedback;Focus Groups;food insecurity;Funding;Future;glycemic control;Goals;health care quality;health disparity;health information technology;health management;Health Services Accessibility;Health system;high risk;implementation science;implementation strategy;improved;improved outcome;Indiana;Informatics;Insulin;Intervention;low health literacy;low socioeconomic status;Manuals;member;Mentors;Methods;minority health;minority health disparity;Modeling;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Nurses;operation;Outcome;Participant;Patient Education;patient engagement;patient outreach;patient portal;patient-clinician communication;Patients;Pharmaceutical Preparations;Phase;Pilot Projects;pilot test;Population;Population Characteristics;population health;Practice Guidelines;pragmatic trial;Problem Solving;Procedures;programs;Protocols documentation;Public Health Informatics;Qualitative Methods;Recommendation;recruit;Reduce health disparities;Registries;remote monitoring;remote patient monitoring;Reporting;Research;Resources;Secure;Self Management;social determinants;Technology;technology validation;Therapeutic;therapy development;Time;tool;Training;transmission process;Universities;virtual;Visit;Work;Writing

PROJECT_TITLE: Improving glycemic control among underserved patients with insulin-treated type 2 diabetes through nurse-led, app-based behavioral intervention

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(84)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Mental Illness;Pediatric;Precision Medicine;Serious Mental Illness

ORG_CITY: CIUDAD DE MEXICO

ORG_COUNTRY: MEXICO

ORG_FIPS: MX

ORG_NAME: NATIONAL INSTITUTE OF PSYCHIATRY

PHR: PROJECT NARRATIVE The research will provide valuable information to school administrators and government policy makers in the participating LMICs to document the burden of CMDs among university students, the extent of unmet need for treatment of these disorders, the effectiveness of inexpensive-scalable e-CBT interventions to treat these disorders, and for whom e-CBT is most effective. The technology transfer part of the study will build capacity to disseminate the methods used for screening, targeting, and intervention implementation so that they can be used in colleges and universities in LMICs throughout Latin America. Such an effort could have enormous public health implications for the region and serve as a model of evidence-based intervention planning and implementation for other parts of the world.

PI_NAMEs: BENJET, CORINA L. (contact);KESSLER, RONALD C

PROGRAM_OFFICER_NAME: CUBILLOS, LEONARDO

PROJECT_TERMS: Address;Administrator;arm;barrier to care;Bipolar Disorder;Brain;California;Cities;Clinic;Cognitive Therapy;Collaborations;college;Colombia;common treatment;comorbidity;computerized;cost;Country;Coupled;Data;design;Detection;Diagnostic;Disease;Disease remission;Dropout;Effectiveness;epidemiology study;evidence base;Evidence based intervention;Exclusion;follow-up;Generalized Anxiety Disorder;Goals;Government;Health;Health Surveys;Heterogeneity;High Prevalence;Impairment;implementation intervention;improved;Income;Infrastructure;Institution;interest;International;Internet;Intervention;intervention effect;Knowledge;Latin America;Latin American;life span;low and middle-income countries;machine learning method;Major Depressive Disorder;medical schools;Mental disorders;Mental Health;mental health policy;Methods;Mexican;Mexico;Modeling;Needs Assessment;Nervous System Disorder;non-affective psychoses;outreach;Pan American Health Organization;Patient Self-Report;Periodicals;Persons;Policies;Policy Maker;Pragmatic clinical trial;Precision therapeutics;Probability Samples;Psychiatric epidemiology;Psychiatry;Public Health;Randomized;Recommendation;Recording of previous events;Reporting;Research;Research Personnel;Resistance;Resources;response;Sample Size;Sampling;Scheme;Schools;screening;Sequential Multiple Assignment Randomized Trial;Services;Students;success;suicidal;Surveys;symposium;Technology;Technology Transfer;Therapeutic Intervention;Training;treatment arm;treatment as usual;treatment effect;trial design;undergraduate student;Universities;university student;Update;Waiting Lists;Work

PROJECT_TITLE: Computerized detection and internet-based treatment of common mental disorders among college students in two Latin American LMICs


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE CD7-initiated signaling has long been regarded as inessential to T cell function. Here, we propose CD7 is an important adaptor protein responsible for recruiting PI3K and amplifying PI3K signaling upon T cell activation, a mechanoforce regulator that stabilizes TCR and peptide–MHC interactions, and a costimulatory molecule that can lower the reactive threshold of T cells. Characterization of CD7-involved signaling may suggest a novel immunomodulatory strategy to augment T cell effector function or subvert T cell exhaustion and senescence during chronic infection, cancer, and aging.

PI_NAMEs: LO, WAN-LIN  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Acute;acute infection;Adaptor Signaling Protein;Address;Adoptive Transfer;aged;Aging;Anti-viral Response;Autoimmune Diseases;autoimmune toxicity;Binding;CD3 Antigens;CD7 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Characteristics;Chronic;chronic infection;Clinical;Complex;Cutaneous T-cell lymphoma;cytotoxicity;Data;design;Disease;Doctor of Philosophy;druggable target;effector T cell;Epigenetic Process;exhaust;exhaustion;experimental study;Extracellular Domain;Freund's Adjuvant;functional adaptation;Functional disorder;Future;Goals;HIV/HCV;Human;Immunity;immunomodulatory strategy;immunomodulatory therapies;immunoregulation;Impairment;In Vitro;in vivo;Infection;Inflammation;Interleukin-2;Laboratories;Ligands;Link;Lymphocytic choriomeningitis virus;Major Histocompatibility Complex;Malignant Neoplasms;medical schools;MHC Interaction;Mission;Modeling;Molecular;Molecular Profiling;Monitor;multiple omics;Mus;mutant;National Institute of Allergy and Infectious Disease;novel;Outcome;Ovalbumin;Pathologic;Peptide Receptor;Peptide/MHC Complex;Physiological;PIK3CG gene;prevent;Production;Proliferating;Property;Proteomics;PTPRC gene;receptor;Receptor Activation;receptor function;Receptor Signaling;recruit;release of sequestered calcium ion into cytoplasm;Role;scaffold;Scaffolding Protein;SECTM1 gene;senescence;Sezary Syndrome;Signal Transduction;Stimulus;synergism;T cell differentiation;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;therapeutic development;transcriptomics;Transgenic Mice;Universities;Utah;Validation;Viral;Virus Diseases;Work

PROJECT_TITLE: Unmasking the Immunomodulatory Roles of CD7 Signaling

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Boston University, The Boston Medical Center Health System, Boston HealtNet, Boston Accountable Care Organization, VA Boston Health System, Edith Norse Rogers Veterans Hospital and the HealthCore/New England Research institutes, Inc comprise the members of the Boston University Clinical and Translational Science Institute (BU CTSI) Hub, supported by a Clinical and Translational Science Award (CTSA) from the National Center for Advancing Translational Science of the NIH. The goals of the BU CTSI, funded since 2008, are: 1. to train a diverse workforce; 2. improve and expedite translational research across the members of the BU CTSI; 3. engage our community in research partnership; 4. develop new methods and resources that improve the science and performance of translational research.

PI_NAMEs: BAIR-MERRITT, MEGAN H;CENTER, DAVID M. (contact)

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: Academic Medical Centers;accountable care organization;Address;Advocate;Basic Science;Boston;Caring;catalyst;Clinical and Translational Science Awards;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;Creativeness;design;Development;Diagnostic;Disadvantaged;disorder control;Disparity population;distrust;Diverse Workforce;empowerment;Environment;ethnic diversity;Ethnic Origin;Funding;Gender;Goals;Health;health care disparity;health disparity;Health Sciences;Health system;Healthcare;Hospitals;Immigrant;improved;Individual;Informatics;Infrastructure;inner city;innovation;Insurance;Language;Learning;life span;low socioeconomic status;Maintenance;Medicaid;Medical center;member;Methods;multidisciplinary;National Center for Advancing Translational Sciences;New England;novel;novel strategies;Outcome;Participant;patient population;Patients;Performance;Persons;Physicians;Policy Maker;poor health outcome;Population;Principal Investigator;Process;programs;Provider;Public Policy;Race;racial diversity;Recording of previous events;Research;Research Infrastructure;Research Institute;residence;Resources;Risk;safety net;Science;Scientist;Socioeconomic Status;Special Population;Substance Use Disorder;tool;Training;Translational Research;Underinsured;United States National Institutes of Health;Universities;Urban Population;Veterans Hospitals;Vision;Workforce Development


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative For patients with gastrointestinal stromal tumor (GIST), our clinical capacity to predict the risk of recurrence following resection or the course of metastatic disease is limited and leads to significant uncertainties in patient care. The oncogenic program underlying GIST is driven by a core group of lineage-specific transcription factors and epigenetic regulators, with resulting disease behavior being dictated by additional disease state-specific accessory transcription factors. This proposal aims to understand the core transcriptional output of GIST, and how accessory transcription factors modify this central program to inculcate disease behavior, with implications for treatment strategies in this disease.

PI_NAMEs: HEMMING, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Address;Adjuvant Therapy;Advisory Committees;Basic Science;Behavior;Binding;Biological;Biological Markers;Biology;career;career development;Caring;cell behavior;Cell Line;Cellular biology;Chemicals;Chromatin;Clinical;Clinical assessments;clinical decision-making;Clinical Management;clinical predictors;clinically relevant;Collaborations;Complex;Dedications;Dependence;Development Plans;Diagnosis;diagnostic tool;Disease;Disease Progression;disorder risk;DNA;Education;Elements;Enhancers;Environment;Epigenetic Process;epigenome;ETV1 gene;Excision;experience;FOXF1 gene;Gastrointestinal Stromal Tumors;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Goals;histone acetyltransferase;histone modification;Immunoprecipitation;improved;Indolent;insight;Institution;Intervention;Label;Laboratories;Location;Maintenance;Malignant Neoplasms;member;Mentors;Mentorship;Mitotic;Molecular;molecular marker;novel;novel strategies;Oncogenic;Operative Surgical Procedures;Outcome;Output;overexpression;Patient Care;Patient-Focused Outcomes;Patients;Pattern;pharmacologic;Physicians;Positioning Attribute;Predictive Value;Process;prognostic tool;prognostication;programs;protein protein interaction;Proteins;Recurrence;Research;research and development;Research Personnel;Risk;risk prediction;risk stratification;Role;Sampling;Sarcoma;Scientist;Soft tissue sarcoma;Specimen;Therapeutic;Training;training opportunity;transcription factor;Translational Research;treatment response;treatment strategy;tumor;Tumor Biology;Tumor Subtype;tumorigenesis;Uncertainty;Unresectable;Work

PROJECT_TITLE: Defining clinically relevant transcriptional networks in gastrointestinal stromal tumor

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE The epidemic of childhood obesity disproportionately impacts low-income, minority communities, strongly predicts obesity and cardiometabolic disease in adulthood, and has few interventions that are scalable, begin early enough to be effective, and address socioeconomic and ethnic disparities. The purpose of this K23 proposal is to prepare the applicant for a career in developing and implementing interventions that begin in pregnancy to prevent child obesity using innovative and scalable delivery platforms, and to adapt and pilot test an evidence-based child obesity prevention intervention to be optimized for remote, virtual delivery. The knowledge gained from this proposal will help to address the critical need for scalable child obesity prevention programs that aim to eliminate disparities in child obesity and its adverse downstream consequences.

PI_NAMEs: KATZOW, MICHELLE WEISS (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: 2 year old;2019-nCoV;acceptability and feasibility;Address;Adult;Adverse event;Articulation;Attitude;Belief;Bottle feeding;Breast Feeding;Cardiometabolic Disease;cardiometabolism;career;career development;Child;Child Rearing;Childhood;Clinical Trials;cohort;Communities;community based participatory research;comparison control;Conduct Clinical Trials;Coupled;COVID-19;Cues;Data;design;Development;disease disparity;Disparity;disparity elimination;Dose;early childhood;efficacy testing;efficacy trial;Enrollment;Epidemic;ethnic disparity;evidence base;experience;Exposure to;Family;feeding;Food;Frequencies;Funding;Future;Geography;Health;High Prevalence;high risk;high risk population;improved;infancy;Infant;infant adiposity;innovation;insight;Interruption;Intervention;Knowledge;Latina;Latinx;Low income;lower income families;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;minority communities;Morbidity - disease rate;mortality;Mothers;National Heart, Lung, and Blood Institute;nutrition;nutrition education;Obesity;obesity in children;obesity prevention;obesity risk;Outcome;Overweight;pandemic disease;Parents;Participant;Persons;pilot test;post-doctoral training;Postpartum Period;power analysis;Predisposition;Pregnancy;pregnant;prenatal;prevent;Prevention program;Preventive;preventive intervention;Primary Care;primary care setting;primary care visit;Process;programs;Psychosocial Stress;Qualitative Methods;Randomized;Randomized, Controlled Trials;recruit;remote delivery;Research Personnel;Resources;response;Risk Factors;Sample Size;Sampling;Science;skill acquisition;skills;Social Conditions;social health determinants;socioeconomic disparity;Special Supplemental Nutrition Program for Women, Infants, and Children;stem;sugar;sweetened beverage;symposium;Technology;telehealth;Testing;usability;videoconference;virtual delivery;Vulnerable Populations;Weight;Woman;women's prevention

PROJECT_TITLE: StEP OUT

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE The proposed research aims to increase our understanding of how cellular machineries accomplish regulated exocytosis, the basis for many fundamental processes such as neurotransmitter release at neuronal synapses which enables neurotransmission in the central nervous system. This research will contribute to understanding mechanisms whereby synapse dysfunction leads to neurodevelopmental or neurodegenerative disorders.

PI_NAMEs: O'SHAUGHNESSY, BEN  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Action Potentials;Beta Cell;Biochemical;Catalogs;Cell fusion;Cell membrane;Cells;Central Nervous System;Chromaffin Cells;Closure by clamp;Communities;Complex;Computer Models;Core Protein;Coupled;Data;Dense Core Vesicle;Docking;Dynamin;Event;Evoked Potentials;Evolution;Exocytosis;experimental study;Family;foot;Functional disorder;Funding;Goals;Grain;Growth;Hormones;Hot Spot;hydrophilicity;Impairment;in silico;Informal Social Control;insulin secretion;Kinetics;Laboratories;Machine Learning;mathematical model;Measurement;Mechanics;Mediating;Membrane;Membrane Fusion;Membrane Lipids;millisecond;model building;Modeling;Molecular;molecular dynamics;multi-scale modeling;Mutate;Mutation;nanodisk;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuroendocrine Cell;Neurons;neurotransmission;neurotransmitter release;Neurotransmitters;novel;Pathway interactions;Physiological;postsynaptic;predictive modeling;Probability;Process;Property;Proteins;reconstitution;Regulation of Exocytosis;Reproducibility;Research;Respiratory Diaphragm;response;Rest;Rotation;Running;Scheme;Secretory Vesicles;sensor;Shapes;Signal Transduction;simulation;Site;SNAP receptor;Stimulus;Structure;Study models;Synapses;Synaptic Cleft;Synaptic Vesicles;synaptotagmin;syntaxin;target SNARE proteins;Testing;Thinness;Type 2 diabetic;Vesicle;vesicular release;vesicular SNARE proteins

PROJECT_TITLE: Modeling SNARE-Mediated Membrane Fusion

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Neurosciences;Nutrition;Obesity;Prevention;Sleep Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE Shift work increases the risk for diabetes possibly due to the adverse metabolic effects of circadian misalignment. As shift work is not foreseen to disappear, the development of individually-targeted therapies for metabolic health in these vulnerable shift workers is urgently needed. This research will determine whether restricting meal timing to the biological day – without disrupting sleep - can mitigate the adverse metabolic effects of circadian misalignment, which may help in the design of evidence-based dietary interventions to improve the metabolic health in shift workers.

PI_NAMEs: SCHEER, FRANK A (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Address;Adverse effects;adverse outcome;animal data;arm;Behavioral;Beta Cell;Biological;Body Weight;causal variant;Cell Physiology;Chronic;circadian;Circadian desynchrony;circadian pacemaker;circadian regulation;Circadian Rhythms;comparison control;Crossover Design;Data;design;Development;diabetes risk;Dietary Intervention;Disease;dysbiosis;Eating;Endotoxins;Etiology;evidence base;experimental study;Fasting;feeding;Food;food restriction;Genetic Carriers;genetic variant;Glucose Intolerance;glucose tolerance;Goals;gut microbiota;Health;Human;impaired glucose tolerance;improved;Individual;Inflammation;inflammatory marker;insulin secretion;insulin sensitivity;Intervention;intestinal barrier;Intestinal permeability;Laboratories;Life Style;Link;Measures;Melatonin;Melatonin Receptors;Metabolic;Metabolic dysfunction;Metabolic Marker;metabolomics;microbial community;microbiota;microbiota composition;microbiota transplantation;Middle Insomnia;Modeling;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Oral;Oranges;Pancreas;Play;Populations at Risk;prevent;Protocols documentation;Randomized;receptor expression;Receptor Gene;Research;Research Design;Risk;risk variant;Role;Saliva;Schedule;Serum Markers;Shapes;shift work;Signal Transduction;Sleep;Sleep disturbances;Sleep Wake Cycle;Socioeconomic Status;stool sample;Structure;systemic inflammatory response;targeted treatment;Testing;Time;trait;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Food Timing to Mitigate Adverse Consequences of Night Work

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE This is a resubmission application for a SPORE in Lung Cancer from the Lung Cancer Program of the Dana- Farber/Harvard Cancer Center (DF/HCC). The DF/HCC seeks to capitalize on important gains in targeted and immunotherapy of lung cancer and develop innovative translational strategies designed to improve lung cancer cure rates.

PI_NAMEs: BARBIE, DAVID A (contact);SEQUIST, LECIA V.

PROGRAM_OFFICER_NAME: UJHAZY, PETER

PROJECT_TERMS: Acceleration;Adaptive Immune System;adaptive immunity;Award;Basic Science;Biology;biomarker driven;Boston;Cancer Center;cancer clinical trial;cancer immunotherapy;Cancer Model;Cancer Patient;Cancer Vaccines;career;Cells;Cessation of life;Clinic;Clinical;Clinical Trials;Collaborations;Combined Modality Therapy;Community Hospitals;cost;Couples;Dana-Farber Cancer Institute;design;Development;Disease;diversity and equity;Drug Tolerance;effective therapy;Enrollment;Epidemiology;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Fostering;Foundations;Funding;General Hospitals;Generations;Geography;Goals;Grant;Hospitals;immune checkpoint blockade;Immune Evasion;Immunotherapy;improved;Individual;Infrastructure;inhibitor;Innate Immune System;innovation;Institution;inter-institutional;Israel;Journals;Lung;Lung Adenocarcinoma;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Massachusetts;Measures;Medical;Medical center;medical schools;member;mouse model;mutant;Mutation;Natural Immunity;next generation;Non-Small-Cell Lung Carcinoma;novel marker;Oncogenes;Outcome;overexpression;patient subsets;Patients;Pediatric Hospitals;prevent;Productivity;programmed cell death protein 1;programs;Protocols documentation;Public Health Schools;Publications;replication stress;Research;Research Personnel;Resistance;Sampling;senescence;Signal Transduction;Site;SMARCA4 gene;Specialized Program of Research Excellence;synergism;Talents;targeted treatment;Teaching Hospitals;Therapeutic;Therapeutic Studies;Time;Translating;translational approach;translational goal;translational scientist;Translations;tumor DNA;Tumor Immunity;tumor immunology;Tyrosine Kinase Inhibitor;United States National Institutes of Health;Vaccines;Woman;Work

PROJECT_TITLE: Dana Farber/Harvard Cancer Center SPORE in Lung Cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lung;Lung Cancer

PI_NAMEs: BARBIE, DAVID A (contact)

PROJECT_TERMS: Administrator;Adult;anti-cancer research;Award;biobank;Cancer Center;Cancer Patient;career;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;Comprehensive Cancer Center;Core Facility;cost;Dana-Farber Cancer Institute;Data Management Resources;data sharing;Development;Ensure;Evaluation;experience;flexibility;Funding;Genomics;Goals;Grant;Guidelines;Hospitals;implementation facilitation;Individual;Institution;Institutional Review Boards;Intellectual Property;Investigation;Joints;Laboratories;Leadership;Licensing;Link;Lung;Malignant neoplasm of lung;Medical;meetings;member;Monitor;new technology;Newly Diagnosed;Office of Administrative Management;Patient advocacy;patient population;Patients;Plasma;Principal Investigator;Procedures;Process;Productivity;programs;Property Rights;Protocols documentation;Qualifying;recruit;Reporting;Research;Research Personnel;Resources;Secure;Specialist;Structure;Talents;Technology;Tissues;translational goal;Translational Research;Vision;Work;Writing

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Elevated expression of the multifunctional transcriptional regulator, Kaiso (ZBTB33) is associated with worse breast cancer survival based on race. In this study we leverage machine learning and artificial intelligence to study a novel breast cancer health disparities cohort to define new functional linkages between Kaiso, autophagy and the tumor microenvironment that contribute to racially disparate breast cancer outcome.

PI_NAMEs: GARDNER, KEVIN L. (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: advanced disease;African ancestry;African Women;Allografting;Artificial Intelligence;Autophagocytosis;Biological;Biological Markers;biomarker identification;Breast;Breast Cancer Cell;breast cancer diagnosis;Breast Cancer Patient;breast cancer progression;breast cancer survival;cancer health disparity;Carcinoma;Cell Nucleus;Cessation of life;cohort;Color;computer scientist;Cytoplasm;Data Scientist;Death Rate;deep learning;deep learning algorithm;Development;Disease;Disease Outcome;Disease Progression;Disparity;disparity reduction;European;Evaluation;Fluorescence;Frequencies;Gene Expression;Genes;Genetic Engineering;Genetic Transcription;Genomics;Goals;Growth;health disparity;Health Services Accessibility;Histopathology;Hormone Receptor;hormone receptor-negative;hormone receptor-positive;Hydroxychloroquine;Immune;Immunohistochemistry;Immunosuppression;Implant;improved;inhibition of autophagy;inhibitor;insight;Knowledge;Link;Machine Learning;Malignant Breast Neoplasm;Malignant Neoplasms;Medical Oncologist;Modality;Modeling;mortality;multidisciplinary;Mus;Mutation;Neoplasm Metastasis;novel;novel therapeutics;Nuclear;Outcome;Pathologist;Pathway interactions;Patients;pharmacologic;Population;predictive marker;Prevalence;Primary Neoplasm;Prognostic Marker;Property;Race;racial difference;racial disparity;racial diversity;Recurrence Score;Regulation;Regulatory Pathway;Reporting;Risk;Role;Sampling;Slide;Socioeconomic Factors;Specimen;survival outcome;Technology;Tissue Microarray;Tissues;transcription factor;treatment response;tumor;tumor behavior;Tumor Biology;tumor heterogeneity;tumor microenvironment;tumor progression;tumor-immune system interactions;United States;Variant;Visual;Woman

PROJECT_TITLE: The linkage between Race, Kaiso and the tumor microenvironment in breast cancer health disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Lung;Lung Cancer;Vaccine Related

PHR: PROJECT NARRATIVE Lung cancer is the leading cause of cancer-related death in the U.S. and worldwide. About 5% of lung cancers are caused by a mutant gene called anaplastic lymphoma kinase (ALK). Although there are several FDA- approved ALK inhibitor pills available for treating this disease, essentially all ALK-mutant lung cancers will develop resistance to these drugs. We have developed a novel ALK cancer vaccine which extends lifespan in mouse models of ALK-mutant lung cancer. In this project, we propose testing this vaccine in patients with ALK- mutant lung cancer with the intent of stimulating patients’ immune systems to recognize and obliterate ALK- mutant cancer cells and cure patients of their cancer.

PI_NAMEs: SHAW, ALICE T (contact)

PROJECT_TERMS: Adjuvant;Adoptive Cell Transfers;Adult;Aftercare;ALK gene;Alleles;anaplastic lymphoma kinase;anti-PD-1;Antitumor Response;Avidity;Biopsy;cancer cell;Cancer Center;Cancer Etiology;Cancer Patient;Cancer Vaccines;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Line;Cell Therapy;Cessation of life;chemotherapy;Chromosomal Rearrangement;Chromosomal translocation;Clinical;Clinical Trials;cohort;crizotinib;Cytotoxic Chemotherapy;Data;design;Disease;Disease Progression;Down-Regulation;Drug resistance;drug resistance development;Drug usage;efficacy testing;Engineering;Enrollment;enzyme linked immunospot assay;Epitopes;Evolution;extend lifespan;FDA approved;first-in-human;Flow Cytometry;Formulation;Foundations;Funding;Future;Genes;Goals;Grant;Haplotypes;Histocompatibility Antigens Class I;HLA A*0201 antigen;HLA-B*0702;Immune;Immune checkpoint inhibitor;immune resistance;Immune response;Immune system;Immunity;immunogenic;immunogenicity;Immunotherapeutic agent;Immunotherapy;Industry;Infiltration;innovation;kinase inhibitor;Length;Libraries;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Microfluidics;Modeling;mouse model;Mus;mutant;neoplastic cell;next generation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;objective response rate;Oncogenes;Participant;participant enrollment;Pathway interactions;patient screening;Patients;PD-1 inhibitors;Peptides;Peripheral Blood Mononuclear Cell;Phase;Phase I Clinical Trials;Phosphotransferases;pill;Positioning Attribute;pre-clinical;primary endpoint;Progression-Free Survivals;Refractory;Relapse;Research;Resistance;Resistance development;resistance mutation;Safety;safety testing;screening;secondary endpoint;Specificity;Stains;success;T cell response;T-Cell Receptor Genes;T-Lymphocyte;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Effect;Time;Tissues;Transgenic Mice;tumor;Tumor Escape;tumor growth;Tumor-Associated Process;Tumor-Infiltrating Lymphocytes;Tyrosine Kinase Inhibitor;Vaccination;Vaccine Adjuvant;vaccine evaluation;vaccine formulation;Vaccinee;Vaccines;Validation

PROJECT_TITLE: Project 1


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunotherapy;Lung;Lung Cancer

PHR: Narrative Loss of function of the SMARCA4/BRG1 gene occurs frequently in lung cancer, yet there is no targeted therapy available for patients with this tumor genotype. Current treatment modalities for these patients are usually ineffective, resulting in death of approximately 16,000 individuals this year in the United States alone. This work will define new precision medicine opportunities for these patients and define how targeting replication stress contributes to therapy response, which will be informative in a wide variety of cancers.

PROJECT_TERMS: anti-PD-1;antitumor effect;Ataxia;ATP phosphohydrolase;biological adaptation to stress;biomarker identification;Biopsy;Cancer Center;Cancer Model;Cancer Therapy Evaluation Program;CD8-Positive T-Lymphocytes;Cell Line;Cessation of life;CHEK1 gene;chemotherapeutic agent;chemotherapy;Chromatin Remodeling Factor;Clinical;clinical development;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Cyclic GMP;Cytotoxic T-Lymphocytes;Defect;DNA;DNA biosynthesis;DNA Damage;DNA damage checkpoint;DNA Double Strand Break;drug candidate;Drug Combinations;effective therapy;Excision;experimental study;Future;Gamma-H2AX;gemcitabine;Gene Expression;Genes;Genetically Engineered Mouse;Genomic Instability;Genotype;Goals;Grant;Human;hydroxyurea;immune checkpoint blockade;Immune system;Immunofluorescence Immunologic;Immunohistochemistry;Immunologic Markers;immunoregulation;Immunotherapy;improved;Individual;inhibitor;Innate Immune Response;innovation;Laboratories;loss of function;Lymphocytic Infiltrate;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Modality;Modeling;Molecular;Mus;mutant;Mutate;Mutation;Non-Small-Cell Lung Carcinoma;novel;Outcome;p53-binding protein 1;Pathway interactions;Patient Care;patient derived xenograft model;patient prognosis;Patients;PD-1/PD-L1;PDL1 inhibitors;phase 1 study;Phosphotransferases;pre-clinical;Pre-Clinical Model;precision medicine;preclinical study;prevent;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;protein expression;Proteins;replication stress;response;Ribonucleotide Reductase;Sampling;Single-Stranded DNA;SMARCA4 gene;Specimen;Stimulator of Interferon Genes;STK11 gene;Stress;Sucrose;System;T cell infiltration;targeted treatment;Testing;Therapeutic;therapeutic target;Topoisomerase Inhibitors;treatment response;tumor;Tumor-infiltrating immune cells;United States;Work;Xenograft procedure

PROJECT_TITLE: Project 2


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Neurosciences;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Chronic kidney disease (CKD) affects 15% of the US adult population and is independently associated with increased cardiovascular (CV) mortality and poor physical capacity. These studies will provide insight into mechanisms of abnormal hemodynamic responses during exercise that contribute to increased CV risk in CKD, and help develop therapeutic targets that are urgently needed to improve physical functioning, and ultimately reduce CV mortality. A multifaceted treatment combining aerobic exercise training with bicarbonate supplementation may be a novel therapeutic approach in CKD that has the potential to improve blood pressure reactivity and physical functioning, as well as impact long-term CV risk.

PI_NAMEs: PARK, JEANIE  (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Acidosis;Acids;Activities of Daily Living;Acute;Adult;Aerobic Exercise;Affect;afferent nerve;ASIC channel;Bicarbonates;Biological Availability;Biological Markers;Blood Pressure;blood pressure elevation;Buffers;cardiovascular risk factor;Cardiovascular system;Chronic Kidney Failure;Clinical;clinical practice;Combined Modality Therapy;Disease;Event;Excretory function;Exercise;exercise capacity;exercise intolerance;exercise training;Funding;Gene Expression;Generations;Goals;hemodynamics;high risk;Human;Hypertension;Imaging Techniques;Impairment;improved;Individual;Inflammation;innovation;insight;interstitial;Intravenous infusion procedures;Ischemia;Isometric Exercise;Isotonic Exercise;Kidney;Kidney Diseases;Knee;lean body mass;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Mediating;Metabolic acidosis;Methods;mortality;Muscle;Near-Infrared Spectroscopy;Nerve;Nerve Endings;neural;neurovascular;novel therapeutic intervention;Oral;Outcome;patient population;Patients;Periodicity;Physical activity;Physical Capacity;Physical Function;Physiological;Placebos;Play;Population;prevent;primary outcome;programs;protein expression;Quality of life;Randomized;receptor;Recommendation;Reflex action;Regulation;rehabilitation strategy;Renal function;Research;response;Rest;restoration;Risk;Role;secondary outcome;Serum;Spinal Ganglia;Sudden Death;Supplementation;Sympathetic Nervous System;systemic inflammatory response;Testing;therapeutic target;Translating;Translational Research;treatment guidelines;Work

PROJECT_TITLE: Neurovascular Regulation During Exercise in Humans With Chronic Kidney Disease

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Lung;Lung Cancer

PHR: PROJECT NARRATIVE The goal of the proposed research is to discover key vulnerabilities in the drug tolerant persister (DTP) cells that remain in oncogene-addicted lung cancers after treatment with effective targeted therapies and eventually lead to acquired drug resistance. We will then test strategies to exploit DTP vulnerabilities to improve outcomes for patients with EGFR mutation-positive NSCLC and other targetable driver abnormalities.

PI_NAMEs: JANNE, PASI A (contact)

PROJECT_TERMS: acquired drug resistance;Aftercare;analytical tool;Apoptosis;Apoptotic;Attenuated;Biological;Biological Models;Biopsy;BRAF gene;Cancer Center;Cancer Patient;Cell Aging;Cell Line;Cells;Clinical;clinical application;clinical development;clinical efficacy;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;combat;Coupled;Data;design;DNA Sequence Alteration;drug development;Drug resistance;Drug Targeting;Drug Tolerance;EGFR inhibition;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;ERBB2 gene;experimental study;Fibroblasts;Foundations;Future;gene repression;Genomics;Genotype;Goals;Growth;improved;improved outcome;In complete remission;In Vitro;in vivo;Infrastructure;inhibitor;innovation;kinase inhibitor;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Modeling;mortality;mutant;Mutation;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Oncogenes;partial response;patient derived xenograft model;Patient-Focused Outcomes;Patients;Phase;Phenotype;Population;Pre-Clinical Model;prevent;pro-apoptotic protein;Quality of life;Research;Residual state;Resistance;resistance mechanism;response;ROS1 gene;senescence;standard of care;Stromal Neoplasm;Symptoms;targeted treatment;Techniques;Testing;Therapeutic;Tissues;treatment response;treatment strategy;tumor;tumor microenvironment;Work

PROJECT_TITLE: Project 3


NIH_SPENDING_CATS: Digestive Diseases;Immunotherapy

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative The intestinal immune system has a unique ability to discriminate harmless commensal microbes from pathogens, yet remarkably little is known about the cell types that initiate tolerance to commensal antigens at the time of colonization in early life. A developmental wave of antigen-presenting cells (APCs) seeds the intestine during the first week of life. This proposal seeks to determine how these APCs establish tolerance to commensal microbiota, the tissue signals that drive their development, and their role in susceptibility to intestinal immune mediated diseases in adulthood.

PI_NAMEs: BROWN, CHRYSOTHEMIS  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Ablation;Acute;Address;Adult;Antigen Presentation;Antigen-Presenting Cells;Antigens;ATAC-seq;Autoimmune;Bacteria;Bar Codes;Biology;Cell Differentiation process;Cell Maintenance;Cell Physiology;cell type;Cells;Chronic;Citrobacter;Colitis;Collaborations;commensal microbes;Computer Analysis;CRISPR/Cas technology;Cues;Dedications;Dendritic Cells;Development;dietary;Disease;Engineering;Failure;fascinate;Generations;Genetic;Genetic Models;Goals;Growth;Health;Heterogeneity;Immune;Immune response;Immune system;Immune System Diseases;Immune Tolerance;in utero;in vivo;Infant;Infection;Inflammation;Inflammatory;Intestines;late life;Life;Listeria;lymph nodes;Malignant Neoplasms;Maps;Mediating;Molecular;mouse model;multiple omics;Mus;Neonatal;neonate;novel;pathogenic microbe;Pathway interactions;Peptides;Peripheral;peripheral tolerance;Phenotype;Population;Postdoctoral Fellow;postnatal period;Predisposition;Pregnancy;Progesterone;programs;Regulation;Regulatory T-Lymphocyte;Reporter;Research;Research Personnel;Risk;Role;Signal Transduction;single-cell RNA sequencing;stem;T cell differentiation;T cell therapy;T-Lymphocyte;therapeutic target;Thymic epithelial cell;Thymus Gland;Time;Tissues;TNFSF11 gene;uptake;Weaning

PROJECT_TITLE: Acceptance of non-self: Decoding intestinal immune tolerance during early life


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Lung;Lung Cancer

PI_NAMEs: YEAP, BEOW YONG  (contact)

PROJECT_TERMS: Animal Experiments;Animal Model;anti-cancer research;biomarker validation;Biometry;Biostatistics Core;Blood;Cancer Center;career;Cell Line;Clinical;Clinical Trials;Code;Collaborations;Complex;Consult;Consultations;Correlative Study;cost;Data;Data Analyses;data exchange;Data Set;Databases;Dedications;density;design;Development;early phase trial;Ensure;Experimental Designs;experimental study;Funding;gene interaction;Generations;Genes;Genetic;Genomics;Genotype;Health protection;Human;human subject;Laboratories;Malignant neoplasm of lung;Molecular;molecular scale;Molecular Target;Monitor;multidimensional data;next generation sequencing;novel;Output;Pathologic;Pathway interactions;personalized medicine;pre-clinical;Process;programs;prospective;Prospective Studies;Quality Control;Research;Research Design;Research Personnel;Resources;Retrospective Studies;Role;Sample Size;Security;Services;Specific qualifier value;Speed;symposium;Testing;Tissues;tool;Translational Research

PROJECT_TITLE: Biostatistics Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Lung;Lung Cancer;Precision Medicine

PROJECT_TERMS: Alleles;Anatomy;Antibodies;Area;automated image analysis;automated segmentation;Biochemical Pathway;Biochemical Process;Biological;Biological Assay;Biological Markers;Cancer Biology;cancer cell;Cancer Center;Caring;Cells;Certification;Clinical;Clinical Pathology;Clinical Treatment;Complement;crizotinib;Custom;Dana-Farber Cancer Institute;Databases;design;detection assay;Detection of Minimal Residual Disease;Development;Diagnosis;Disease;Epidermal Growth Factor Receptor;Erlotinib;Etiology;Expression Profiling;Gefitinib;Gene Expression Profiling;Genetic;Genomics;Genotype;Goals;Histologic;Hybrids;Image;Immune;immune cell infiltrate;Immunofluorescence Immunologic;Immunohistochemistry;Immunophenotyping;immunoregulation;improved;In Situ;Individual;inhibitor;innovation;International;Intervention;Ions;Knowledge;Laboratories;Malignant neoplasm of lung;Malignant Neoplasms;Manuals;Massive Parallel Sequencing;Measures;Medicine;Microscopic;Molecular;Molecular Genetics;molecular pathology;Monitor;Multiplexed Ion Beam Imaging;Mutation;nano-string;next generation sequencing;novel;novel marker;Oncogenic;Pathologist;Pathology;Patient Monitoring;Patient Selection;Patients;Periodicity;Plasma;Procedures;protein biomarkers;protein expression;Proteins;Protocols documentation;quality assurance;Quality Control;Reproduction spores;Research;Research Personnel;Resources;response;RNA analysis;ROS1 gene;sample collection;Sampling;Scanning;Selection for Treatments;Seminal;sequencing platform;Services;skills;Slide;Specimen;standard of care;Structure of parenchyma of lung;Supervision;System;Techniques;Technology;Tissue Banks;Tissue Microarray;Tissue Sample;Tissues;Transcript;transcriptomics;Translational Research;treatment and outcome;tumor;tumor DNA;tumor microenvironment;Tumor Tissue;Validation;Vertebral column;Work

PROJECT_TITLE: Pathology & Genomics


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Dietary Supplements;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Inflammatory Bowel Disease is multifactorial and caused by the interplay of genetics, the microbiome and environmental factors. Diet is one of the most prominent environmental factors influencing IBD, however the major challenge for implementing dietary therapy for IBD is the lack of understanding of detailed mechanistic pathways to explain the impact of dietary interventions. The overall goal of this project is to discover relevant dietary fiber-microbe-immune cell interactions that prevent, induce or alter the course of gut inflammation.

PI_NAMEs: CERVANTES BARRAGAN, LUISA  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Affect;American;Bacteria;Behavior;Body Weight decreased;C57BL/6 Mouse;Carbon;CD4 Positive T Lymphocytes;Cell Communication;Cell Physiology;Cells;Chronic;Citrobacter rodentium;Colitis;Colon;Complex;Consumption;Crohn's disease;cytokine;design;Development;Diet;Diet therapy;dietary;dietary constituent;Dietary Fiber;Dietary Intervention;Disease;Disease Progression;Energy-Generating Resources;Environment;Environmental Risk Factor;epidemiology study;Europe;experimental study;feeding;Fiber;Flow Cytometry;Food;gain of function;Genetic;Germ-Free;Goals;gut inflammation;gut microbiota;Gut Mucosa;Health;Histologic;Human;human microbiota;IL17 gene;Ileitis;Immune;immune cell infiltrate;Immune response;Immune system;immunoregulation;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Intake;interest;Intervention;Intestinal Mucosa;Intestines;intraepithelial;Lamina Propria;Large Intestine;LCN2 gene;Macronutrients Nutrition;Measures;Mediating;member;Metabolic;Metabolic Pathway;Metagenomics;Microbe;microbial;microbiome;microbiome composition;microbiota;microbiota composition;Modeling;mouse model;Mucositis;Mucous Membrane;Mus;nutrition;nutritional approach;Pathogenesis;Pathology;Pathway interactions;Persons;Population;prevent;Process;programs;Regulation;Regulatory T-Lymphocyte;Research;response;Rest;Risk;Role;Series;Severities;Severity of illness;Small Intestines;stool sample;Structure;Supplementation;T-Cell Development;T-Lymphocyte;Toxoplasma gondii;Ulcerative Colitis;Volatile Fatty Acids

PROJECT_TITLE: Role of dietary fiber-microbiota Interactions in the development and function of small intestinal T cells


PI_NAMEs: HEIST, REBECCA SUK (contact)

PROJECT_TERMS: Address;Advisory Committees;Award;Basic Science;Boston;Cancer Center;Collaborations;Credentialing;Dana-Farber Cancer Institute;Development;diversity and inclusion;Doctor of Philosophy;Eligibility Determination;Ensure;Faculty;Funding;Funding Mechanisms;Future;Goals;Growth;high risk;innovation;Institution;interest;Knowledge;Leadership;Lung;Malignant neoplasm of lung;medical specialties;member;Mentors;Minority Groups;Mission;Monitor;novel;Peer Review;Phase;posters;Process;Program Research Project Grants;programs;Request for Applications;Research;research and development;Research Personnel;Research Project Grants;Research Proposals;response;Secure;Standardization;success;Talents;Underrepresented Minority;Woman

PROJECT_TITLE: Developmental Research Program


PI_NAMEs: COSTA, DANIEL BOTELHO (contact)

PROJECT_TERMS: Advisory Committees;Appointment;Award;Biology;Cancer Center;career;Collaborations;Dana-Farber Cancer Institute;Department chair;Diagnosis;Discipline;diversity and inclusion;Doctor of Philosophy;Electronic Mail;Environment;Epidemiologist;Exposure to;Faculty;faculty mentor;Fellowship Program;Female;Funding;Goals;Individual;Institution;Instruction;Leadership;Letters;Lung;Malignant neoplasm of lung;Medical Oncologist;member;Mentors;Minority;Minority Recruitment;Monitor;multidisciplinary;Nature;next generation;Postdoctoral Fellow;Prevention;Program Description;programs;Radiation Oncologist;radiologist;Request for Applications;Research;Research Personnel;Research Support;success;Surgeon;Training;translational cancer research;translational progress;Translational Research;translational research program;translational scientist;tumor

PROJECT_TITLE: Career Enhancement Program


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Mental Health;Mental Illness;Neurosciences;Pediatric;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Many severe mental disorders are characterized by impairments in social interactions, yet these diseases are poorly understood, and current treatments are lacking to treat them effectively. Advanced molecular and genetic technologies allow for the dissection of dedicated neural pathways involved in specific behaviors, providing novel targets for diagnosis and therapeutic development. This proposal aims to leverage cutting edge molecular, electrophysiological and imaging approaches to uncover the molecular, biophysical and systems-level regulation of neural circuits underlying affiliative and agonistic behavior of males and females toward infants.

PI_NAMEs: DULAC, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Adult;Affect;affiliative behavior;Aggressive behavior;Agonistic Behavior;Animals;Architecture;Area;Atlases;autism spectrum disorder;Behavior;Behavioral;biophysical properties;biophysical techniques;Biophysics;burden of illness;Calcium;caregiving;Caring;cell type;Cells;Child Rearing;Dedications;Diagnosis;diagnostic development;Disease;Dissection;Electrophysiology (science);Endocrine;experience;Fathers;Female;Functional disorder;Funding;Galanin;Gene Expression;Genetic;genetic approach;Genetic Techniques;genetic technology;Genetic Transcription;Goals;Grant;Head;Hormonal;Hormone Receptor;Human;Hypothalamic structure;Image;imaging approach;Impairment;In Situ;in vivo;Infant;Infant Care;Infanticide;innovation;Major Depressive Disorder;male;Medial;Mediating;Mental Depression;microendoscope;microendoscopy;Molecular;Monitor;Mothers;Motivation;Motor;Mus;neglect;neural;neural circuit;Neural Pathways;neurobiological mechanism;neuromechanism;Neuromodulator Receptors;Neurons;neurophysiology;neuroregulation;novel;novel therapeutic intervention;offspring;Partner in relationship;Personal Satisfaction;pharmacologic;Physiological;Population;Preoptic Areas;pup;Regulation;Resolution;Role;Schizophrenia;severe mental illness;sex;single nucleus RNA-sequencing;Slice;social;Social Behavior;social deficits;Social Interaction;Specificity;Stereotyping;Synapses;System;Therapeutic;therapeutic development;tool;Transcriptional Regulation;Translating;urocortin;Variant;Viral;Work

PROJECT_TITLE: Microcircuits underlying murine parental behavior

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: NARRATIVE Non-small cell lung cancer is one of the most common neoplasms worldwide and associates with poor survival and high mutation rate. Despite the significant advances in the development of molecularly targeted therapy in last decade, tumors with the most prevalent KRAS mutations remain refractory to targeted therapy. Based on compelling preliminary data, we will dissect the functional roles of SETDB1, a major H3K9 methyltransferase in regulating malignant progression of KRAS mutant non-small cell lung cancer, determine the importance of its monoubiquitination and catalytic activity, and elucidate the underlying mechanisms. This innovative project will not only decipher epigenetic mechanisms contribute to oncogenic KRAS-induced transcription reprogramming in lung cancer progression, but also highlight novel therapeutic opportunities for targeting.

PI_NAMEs: FANG, JIA  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Alleles;Attenuated;Biochemical;biomarker development;biomarker driven;BRAF gene;Cancer Etiology;CDX2 gene;cell motility;Cell Physiology;Cells;Clinical;cohort;Common Neoplasm;Complex;Data;Development;driver mutation;Drug Targeting;Endogenous Retroviruses;Enzymes;Epidermal Growth Factor Receptor;Epigenetic Process;Extracellular Matrix;Family;gain of function;gene repression;Gene Silencing;Genes;genetic signature;Genetically Engineered Mouse;Goals;Heterochromatin;histone modification;Histones;Human;human disease;In Vitro;in vivo;innovation;insight;Invaded;KRAS oncogenesis;KRAS2 gene;KRASG12D;Link;loss of function;Lung;Lung Adenocarcinoma;lung cancer cell;Lysine;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Methylation;Methyltransferase;migration;Modeling;Modification;Molecular;molecular targeted therapies;Monoubiquitination;mortality;mouse model;Mus;mutant;Mutation;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Oncogenic;Pathway interactions;Patients;Phenotype;Play;Process;Prognosis;Proteins;Proteomics;Refractory;Regulation;Repression;restraint;Role;SETDB1 gene;Signal Transduction;subcutaneous;System;targeted treatment;Therapeutic;therapeutically effective;transcription factor;Transcriptional Activation;transcriptional reprogramming;tumor;tumor growth;tumor progression;Tumor Suppressor Genes;Ubiquitination;Up-Regulation;Xenograft Model

PROJECT_TITLE: Dissecting the Mechanism of SETDB1 and its K867 Monoubiquitination in Lung Cancer Progression

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_DEPT: CHEMISTRY

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

PHR: Project Narrative The proposed research will increase our understanding of how Salmonella enterica tolerates and distributes copper. Copper, as part of the innate immune response, is used as a bactericide agent by the human host to control/restrict/limit Salmonella infection. The links between copper and periplasmic redox stress response will be also identified. The proposed studies are relevant to public health because Salmonella enterica causes gastroenteritis and systemic diseases in humans.

PI_NAMEs: ARGUELLO, JOSE M (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Affinity;Bacterial Infections;bactericide;Binding;Binding Proteins;Biochemistry;Bioinformatics;biological adaptation to stress;Biological Assay;Biology;cell envelope;Cells;Chemistry;cofactor;Complex;Copper;Cytoplasm;Data;Dedications;Elements;Enterobacteriaceae;enzyme activity;Enzymes;Equilibrium;Evaluation;experimental study;extracellular;Gastroenteritis;Genetic Transcription;Goals;Homeostasis;Human;human pathogen;In Vitro;in vivo;Infection;Innate Immune Response;Innate Immune System;innovation;Ions;Joints;Kinetics;Laboratories;Link;mathematical model;Measures;Membrane;Membrane Transport Proteins;metalloenzyme;Metals;Methodology;Micronutrients;Modeling;Molecular;Molecular Chaperones;Monitor;mutant;novel;Organism;Oxidation-Reduction;pathogen;pathogenic bacteria;periplasm;Periplasmic Proteins;Phagosomes;Play;Positioning Attribute;Proteins;Proteomics;Public Health;Reporting;Research;Respiratory Burst;response;Role;Salmonella;Salmonella enterica;Salmonella infections;Specificity;stoichiometry;Stress;System;Systemic disease;Systemic infection;Testing;Toxic effect;Transition Elements;uptake;Virulence

PROJECT_TITLE: Molecular determinants of Salmonella cell-envelope copper homeostasis

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Cancer;Clinical Research;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Esophageal Cancer;Health Services;Precision Medicine;Prevention;Primary Health Care;Rare Diseases

PHR: There are new technologies and methods to screen for esophageal cancer that are less invasive than the prior method of endoscopy. We propose to evaluate whether a screening strategy that uses such a technology and accounts for individual patient characteristics could be effective to reduce the burden of esophageal cancer.

PI_NAMEs: HUR, CHIN  (contact)

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Award;Biopsy;burden of illness;Cancer Control;Case Fatality Rates;Cells;Characteristics;Clinical Research;Collaborations;Colorectal Cancer;cost;Cost Analysis;cost effective;cost effectiveness;cost estimate;Data;Devices;Effectiveness;Endoscopy;Esophageal Adenocarcinoma;Esophagus;experience;Financial cost;Foundations;Funding;future implementation;Goals;Health system;Healthcare Systems;high risk;Histologic;implementation barriers;improved;Incidence;Individual;individual patient;innovation;insight;Life Expectancy;Malignant neoplasm of esophagus;Malignant Neoplasms;Mass Screening;member;Methods;Modality;Modeling;models and simulation;Morbidity - disease rate;mortality;Natural History;new technology;novel;novel strategies;Patients;Performance;personalized approach;personalized screening;Population;Prevention;Primary Care;primary care setting;Procedures;profiles in patients;Provider;Recommendation;Regimen;Research;Research Personnel;Research Project Grants;Risk;Sampling;screening;Screening for cancer;screening program;Technology;Testing;Western World;Work

PROJECT_TITLE: A Personalized Approach to Targeted Esophageal Cancer Screening

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-W(03)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This research aims to contribute to the health of people with cancer by improving the treatment of depression in this population. The study will develop technology to optimize the delivery of an effective system of care for depression, called Collaborative Care Management. Improving the ability to effectively treat depression in people with cancer will reduce the disabling effects of cancer and its treatment and improve overall quality of life.

PI_NAMEs: FANN, JESSE R (contact)

PROGRAM_OFFICER_NAME: RANDHAWA, GURVANEET

PROJECT_TERMS: Adherence;Administrator;Adopted;Adoption;Affect;Age;anti-depressive agents;Anxiety;arm;Behavior Therapy;Behavioral;cancer care;Cancer Center;Cancer Patient;cancer therapy;care systems;Caring;Case Manager;Characteristics;Client satisfaction;Clinical;Collaborations;collaborative care;Collection;comorbidity;cost effective;Depressed mood;depressive symptoms;Development;digital data;digital platform;Disability scale;Disabling;dosage;Economics;effective therapy;Effectiveness;effectiveness-implementation RCT;eHealth;Enhancement Technology;Ensure;Ethnic Origin;European Organization for Research and Treatment of Cancer;evidence base;evidence based guidelines;experience;Female;follow-up;future implementation;Guideline Adherence;Guidelines;Health;Health Care Costs;Healthcare;human centered design;Hybrids;implementation fidelity;improved;integrated care;Interview;iterative design;literacy;Malignant Neoplasms;Managed Care;Measurement;Measures;Medical;Mental Depression;Mental Health;Mental Health Services;Meta-Analysis;Methods;mobile application;mobile computing;Modeling;Monitor;Morbidity - disease rate;mortality;Needs Assessment;Nurses;optimism;Outcome;Output;Pain;patient engagement;Patient Monitoring;patient oriented;Patient Outcomes Assessments;patient population;patient registry;Patients;Penetration;Perception;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacotherapy;Phase;phase 1 study;phase 2 study;Population;population based;Process;Provider;Psychologist;psychopharmacologic;psychosocial;Psychosocial Assessment and Care;Quality of life;Questionnaires;Research;Resources;Rural;rural area;rural setting;service delivery;Severities;sex;shared decision making;Site;social stigma;Social Workers;Structure;Symptoms;System;Technology;Testing;Therapeutic;Time;tool;Transportation;Treatment Effectiveness;treatment guidelines;web app;web platform;web site

PROJECT_TITLE: Using Technology to Optimize Collaborative Care Management of Depression in Urban and Rural Cancer Centers

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

PHR: Hypoparathyroidism is a rare disorder with devastating complications, but there are no prospective natural history studies on the long-term effects of the disease. This study will provide a rigorous standardized approach to longitudinal data collection on end-organ damage in hypoparathyroidism. The findings will advance monitoring practice paradigms and support product development for this rare disease.

PI_NAMEs: NICKOLAS, THOMAS L.;RUBIN, MISHAELA R (contact)

PROGRAM_OFFICER_NAME: MUELLER, CHRISTINE

PROJECT_TITLE: Advancing Product Development for Hypoparathyroidism: A Prospective Natural History Study of the Clinical Outcomes and Regulation of Disordered Mineral Metabolism


ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative--Overall The Mays Cancer Center (MCC) at the University of Texas Health San Antonio (UT Health SA) is the National Cancer Institute-designated Cancer Center (NCICC) for a 38-county region of Central and South Texas, a region of 45,926 square miles with 4.9 million individuals who have a unique set of cancer-related challenges. The population in this catchment area is predominantly Hispanic, the fastest growing demographic in the United States (U.S.). The mission of the MCC is to reduce the cancer burden in Central and South Texas through the highest quality cancer care with expanded treatment options from our early phase clinical trials, ground- breaking cancer research aimed at reducing the incidence and mortality of cancer as well as improving treatment options, education of the future leaders of cancer scientists and clinicians, and cancer prevention programs that focus on our unique population. The MCC strives to be the institution of choice for cancer care in South Texas, a highly-productive research institution that attracts and retains the best cancer scientists, is the institution of choice for cancer education, and an organization devoted to reducing the burden of cancer in our region. The MCC has continued its focus on serving our unique South Texas population which is predominantly Hispanic (69%). The population of San Antonio’s metropolitan area is about 63% Hispanic, while parts of South Texas included in our catchment area are more than 90% Hispanic. Our goal is for the MCC to be a national resource where personalized, culturally-sensitive clinical care and scientific discovery will be conducted, focusing on the unique population of San Antonio and South Texas, to be used as the precepts for cancer control for the U.S. which, with changing demographics, will face many of the current challenges of our region in the future.

PI_NAMEs: ZHENG, LEI  (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: anti-cancer research;Area;Basic Science;Cancer Burden;cancer care;Cancer Center;Cancer Control;cancer education;cancer health disparity;cancer initiation;cancer prevention;Cancer Science;cancer therapy;Catchment Area;Clinical Cancer Center;clinical care;clinical practice;Communities;Complex;County;demographics;Disparity;early phase clinical trial;Education;efficacious treatment;Face;Five-Year Plans;Future;Future Generations;Goals;Growth;Health;health disparity;Hispanic;improved;Incidence;Individual;Institution;Latino Population;Leadership;Malignant Neoplasms;metropolitan;Mission;Molecular;mortality;National Cancer Institute;next generation;Outcome;outreach;patient oriented;Phase;Population;population health;Population Sciences;predictive marker;Prevention;Prevention program;Productivity;Prognostic Marker;programs;Research;Research Personnel;Resources;Science;Scientist;screening;Screening for cancer;South Texas;Strategic Planning;targeted cancer therapy;Texas;Therapeutic;Training;Translational Research;tumor progression;United States;Universities;Work

PROJECT_TITLE: Mays Cancer Center at UT Health SA

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: PADALECKI, SUSAN S (contact)

PROJECT_TERMS: American Cancer Society;Area;Award;biobank;Cancer Center;Cancer Center Support Grant;Collaborations;community engagement;Community Outreach;Complex;Data;Development;Education;Electronics;Employee;Evaluation;Extramural Activities;Faculty Recruitment;Funding;Future;Grant;Health;Informatics;Institution;Leadership;Malignant neoplasm of prostate;Malignant Neoplasms;member;Mission;NCI Center for Cancer Research;Nursing Faculty;Philanthropic Fund;Process;Productivity;programs;recruit;Reporting;Research;research faculty;Research Peer Review;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Strategic Planning;symposium;Texas;tool;Translating;Universities;working group


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: Bloomington

ORG_NAME: HEALTHPARTNERS INSTITUTE

ORG_STATE: MN

PHR: Project Narrative Clinical trials are a vital part of the research process. Access to oncology clinical trials remains essential to address the many unmet needs in cancer prevention, control, screening, and treatment. The bulk of cancer care takes place in community settings, so allowing patients from community hospitals to participate in national clinical research allows access to a larger, more diverse patient population to promote increased patient outcomes and reduce disparities. With this funding opportunity, the Metro-Minnesota Community Oncology Research Consortium (MMCORC) will continue to provide people in our community access to the newest therapies available for cancer treatment, symptom management, and cancer prevention, along with the opportunity to participate in trials that examine how the cancer care delivery process influences clinical outcomes and patient well-being.

PI_NAMEs: ANDERSON, DANIEL M (contact);JI, YAN ;KING, DAVID

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Address;advocacy organizations;Advocate;American Cancer Society;American College of Radiology Imaging Network;Award;Awareness;base;cancer care;Cancer Center;cancer clinical trial;Cancer Control;cancer health disparity;Cancer Hospital;Cancer Patient;cancer prevention;Cancer Research Project;cancer therapy;care delivery;Catchment Area;Clinic;Clinical;Clinical Oncology;Clinical Research;Clinical Trials;Clinical Trials Support Unit;Clinics and Hospitals;Collaborations;Communication;Communities;Community Clinical Oncology Program;Community Hospitals;Community Participation;Community Physician;community setting;Comprehensive Cancer Center of Wake Forest University;design;Discipline of obstetrics;disparity reduction;Eastern Cooperative Oncology Group;Enrollment;Ensure;Environment;Evaluation;Funding;Funding Opportunities;Future;Goals;Grant;Growth;Gynecologic Oncology;Gynecology;Health;health assessment;health care availability;Health Care Reform;health plan;Health Planning Councils;Health Professional;Hematology;Hospital Administrators;Hospitals;Image;Improve Access;improved;Individual;Intervention;Knowledge;Malignant Neoplasms;Marketing;Medical Oncology;member;Methods;Minnesota;Minority Groups;Modeling;Names;National Cancer Institute;neuro-oncology;Nurse Practitioners;Oncologist;Oncology;oncology program;organizational structure;Outcome;outcome disparities;outreach program;Palliative Care;Pamphlets;Participant;participant enrollment;Patient advocacy;patient population;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;Physician Assistants;Population Heterogeneity;Positioning Attribute;precision medicine;Prevention;Primary Care;Procedures;Process;programs;Protocols documentation;Quality of life;Radiation Oncology;Radiology Specialty;Recording of previous events;Research;Research Institute;Research Personnel;Research Proposals;Resources;Rural;screening;Services;Site;social media;socioeconomics;Southwest Oncology Group;success;Surgical Oncology;symptom management;Testing;Thoracic Surgical Procedures;Time;Underrepresented Populations;Underserved Population;Universities;web site;Wisconsin


NIH_SPENDING_CATS: Cancer;Pediatric

PI_NAMEs: LEACH, ROBIN JEAN (contact)

PROJECT_TERMS: Accreditation;anti-cancer research;Area;Basic Science;Cancer Center;career;career development;Catchment Area;Categories;Cities;Clinical;clinical care;college;Communities;Dedications;Dentistry;Discipline of Nursing;Doctor of Dental Surgery;Doctor of Medicine;Doctor of Philosophy;Doctor's Degree;doctoral student;drug development;Education;experience;Faculty;Fellowship;Fostering;Funding;Future;Goals;graduate school;graduate student;Health;Health Occupations;Health Personnel;Health Sciences;Hematology;high school;High School Student;Hispanic;Hispanic Populations;Hispanic-serving Institution;improved;Individual;Infrastructure;Institution;interest;Malignant Neoplasms;Medical;Medical Oncology;medical schools;Medical Students;meetings;member;Mentors;metropolitan;Middle School Student;Minority;minority student;Mission;NCI Center for Cancer Research;next generation;Nursing Faculty;Oncology;Outcome;Pediatric Hematology;Physicians;Population;Productivity;programs;Reporting;Research;Research Activity;Research Personnel;Research Training;Resource Development;Resources;Robin bird;Schools;Science;Scientist;skills;South Texas;Students;summer research;Texas;Training;Training Activity;Training and Education;training opportunity;Training Programs;translational cancer research;Travel;undergraduate student;Underrepresented Populations;underserved minority;Universities;university student;Urologic Oncology