NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Lung;Lung Cancer;Mental Health;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE PUBLIC HEALTH RELEVANCE: Research indicates that perceived stigma within medical encounters is prevalent and problematic for lung cancer patients’ well-being and quality of cancer care. Promoting empathic communication appears to be a potentially effective intervention target to help reduce patients’ perceptions of stigma within clinical encounters; however, no formal trainings exist that focus on teaching empathic communication to oncology care providers (OCPs). Building upon favorable findings from a prior R21 (R21CA202793) and the importance of developing interventions to address lung cancer stigma, our goal is to conduct a national trial of empathic communication skills (ECS) training to facilitate improvements in the medical and psychosocial care of patients through de-stigmatizing interactions with OCPs for patients diagnosed with lung cancer.

PI_NAMEs: BANERJEE, SMITA  (contact);OSTROFF, JAMIE S.

PROGRAM_OFFICER_NAME: VANDERPOOL, ROBIN CLINE

PROJECT_TERMS: Address;advocacy organizations;American Cancer Society;arm;Attitude;cancer care;cancer diagnosis;Cancer Patient;care delivery site;care outcomes;care providers;care systems;Client satisfaction;Clinical;clinical encounter;Clinical Nursing;Clinical Trials;clinically relevant;Cluster randomized trial;Communication;Communication difficulty;Communities;Community Clinical Oncology Program;Community Healthcare;Community Networks;Comprehensive Cancer Center;Consent;Continuity of Patient Care;Control Groups;Counseling;Diagnosis;Disclosure;Distress;Educational process of instructing;effective intervention;Effectiveness;Emotions;Empathy;empowerment;Evaluation;experience;Family;former smoker;Foundations;Friends;Funding;General Population;Goals;group intervention;Guilt;Health;health assessment;Health Personnel;help-seeking behavior;Hour;improved;Intervention;Lung;Malignant neoplasm of lung;Measures;Medical;Medical History;multi-site trial;Nurse Practitioners;Nurses;Oncology;Outcome;Participant;Patient advocacy;Patient Care;Patient Outcomes Assessments;patient-clinician communication;Patient-Focused Outcomes;Patients;Perception;Personal Satisfaction;Physician Assistants;Physicians;Pilot Projects;pilot test;pilot trial;primary outcome;Provider;psychological distress;psychological outcomes;Psychosocial Assessment and Care;public health relevance;Pulmonology;Regrets;relapse prevention;Reporting;Research;response;satisfaction;secondary outcome;Self Efficacy;Services;Shame;Site;skills;skills training;Smoke;Smoker;Smoking;Smoking Behavior;Smoking History;Social isolation;social stigma;stem;Symptoms;Thoracic Oncology;Thoracic Surgical Procedures;Tobacco Use Cessation;Training;Training Activity;treatment as usual;uptake;Waiting Lists;Well in self

PROJECT_TITLE: Empathic Communication Skills Training to Reduce Lung Cancer Stigma

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE: USC TCORS OVERALL Th USC TCORS will conduct research that will identify how adolescents and young adults are impacted by novel oral nicotine products, e-cigarettes, and other tobacco products. We will also identify if certain characteristics of nicotine products, like the flavor, and the marketing strategies have an especially strong impact on young people. This research will inform future FDA policies addressing these nicotine products by identifying the likely impact that new regulations may have on preventing nicotine use in young people.

PI_NAMEs: LERMAN, CARYN ;LEVENTHAL, ADAM MATTHEW (contact)

PROGRAM_OFFICER_NAME: PRUTZMAN, YVONNE M

PROJECT_TERMS: abuse liability;Achievement;addiction;Address;Adolescent and Young Adult;Adult;Age;Area;Automobile Driving;Behavior;career;Characteristics;Cigarette Smoker;Classification;cohort;Collaborations;Communication;Communities;computerized data processing;Creativeness;crowdsourcing;Data;Data Analyses;Data Analytics;data management;Databases;design;Development;Electronic cigarette;electronic cigarette user;Epidemiology;Esthesia;Ethnic Origin;experimental study;Fostering;Future;Gender Identity;Harm Reduction;health disparity;Immersion;Infrastructure;innovation;Leadership;Longitudinal cohort study;Marketing;Measures;Mental Health;Mentors;Methods;Modernization;Monitor;Names;next generation;Nicotine;nicotine use;novel;Oral;outreach;Pattern;Peer Review;Persons;Pilot Projects;Policies;Population;post-market;Postdoctoral Fellow;Predisposition;prevent;Productivity;programs;progression risk;Publishing;Race;recruit;Reduce health disparities;Regulation;Research;Research Personnel;response;Risk;Sales;Sampling;Science;Scientist;Sexual and Gender Minorities;social media;Speed;Stimulus;Surveys;synergism;Testing;TikTok;Time;Tobacco;tobacco advertising;tobacco products;tobacco regulatory science;Tobacco use;Training;trend;uptake;virtual visit;young adult;Youth

PROJECT_TITLE: USC Tobacco Center of Regulatory Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-R(50)R]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: Narrative: Epilepsy contributes a significant proportion of the world’s burden of disease and is associated with widespread discrimination and stigma which together with other drivers of the treatment gap prevent most PWE from reaching medical care. A complete understanding of its characterization, comorbidities and risk factors is inevitable for developing targeted preventive strategies and other interventions. Community engagement programs addressing epilepsy related stigma especially among the vulnerable adolescents can favorably impact quality of life, reduce disability, and create a fundamental shift in the perception of and behavior related to epilepsy.

PI_NAMEs: KAKOOZA, ANGELINA MWESIGE (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Achievement;Address;Adolescent;Adult;Affect;Africa South of the Sahara;Anticonvulsants;Anxiety;Attitude;Behavior;Birth trauma;Brain;Brain Diseases;burden of illness;Burn injury;care outcomes;care seeking;Caregivers;Caring;Characteristics;Child;Classification;Clinic;Clinical;cohort;Communities;community engagement;comorbidity;Corrosives;cost;Coupled;design;Development;developmental disease;disability;Discrimination;Emotional;Epilepsy;experience;Exposure to;Foundations;Frequencies;functional outcomes;functional status;genetic risk factor;Goals;Health;Health Policy;improved;Individual;Infrastructure;innovation;International;Intervention;Knowledge;life span;Malnutrition;Medical;meetings;Mental Depression;Mental Health;Methods;mortality;Nervous System Disorder;Neurocognitive Deficit;Occupational;Occupational Status;Outcome;Output;Participant;Patients;Perception;Personal Satisfaction;Persons;Pharmaceutical Preparations;Population;prevent;Prevention strategy;Probability;programs;Psyche structure;psychiatric comorbidity;psychosocial outcome;Public Health;Quality of life;Random Allocation;Reporting;Research;Resource-limited setting;Resources;response;Rest;Risk;Risk Factors;Sampling;Seizures;Severities;Severity of illness;social;social exclusion;social stigma;Stigmatization;Subgroup;suicidal;Sustainable Development;Testing;Translating;Uganda;Universities;vulnerable adolescent;Vulnerable Populations;Work;World Health Organization;Writing

PROJECT_TITLE: Epilepsy in Uganda: Clinical characterization and co-morbidities, their relation to stigma among adolescents and impact of a community-based engagement program (AWE Change project)


PI_NAMEs: LEVENTHAL, ADAM MATTHEW (contact)

PROJECT_TERMS: Address;Administrative Supplement;Alaska Native;American Indians;Area;Behavior;Biological Assay;Candy;Characteristics;Cigarette;Classification;combustible tobacco;Communities;Cross-Sectional Studies;Data;Data Set;Data Sources;data standards;Dental Epidemiology;depressive symptoms;design;Dose;Electronic cigarette;electronic cigarette use;Epidemiology;Esthesia;Ethnic Origin;experience;flexibility;Frequencies;Fruit;Funding;Future;Genus Mentha;Goals;Growth;Hybrids;Ice;Inequality;JUUL;Link;Marketing;Measures;Medicine;Mental Health;Menthol;Methods;Modernization;Monitor;Names;Nicotine;novel;Oral;Persons;Policies;Population;Prevalence;Race;Race Relations;Regulation;Reporting;response;Role;Rural;rural residence;Sales;Sample Size;Sampling;Science;Sensory;Smokeless Tobacco;snus;substance use;Surveys;Testing;Tobacco;tobacco flavor;tobacco products;tobacco regulatory science;Tobacco use;tobacco-free;tool;trend;United States National Institutes of Health;Update;uptake;vaping;Youth

PROJECT_TITLE: Project 1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-R]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Lung;Mental Health;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Proposal Narrative Breathing rapidly switches between different patterns in response to the interoceptive signals from the body, and its dysfunction results in serious pathological conditions. The proposed studies here will reveal the neural circuits underlying two discrete and critical breathing patterns in response to different stimuli. This work will lead to not only better understanding of the functional neural circuits for interoception, but also the identification of the endogenous neural pathways underlying these two critical breathing responses, thereby providing new opportunities for the development of novel therapeutics for breathing abnormalities.

PI_NAMEs: LI, PENG  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Ablation;Acute;Afferent Pathways;Blood gas;Brain;Brain Death;Brain region;Breathing;Calcium;Carotid Body;Central Nervous System;Characteristics;Clinical Research;cognitive process;Coughing;COVID-19;Development;Drug abuse;effective therapy;Emotional;Esthesia;experimental study;expiration;Foreign Bodies;Foundations;Functional disorder;Future;Ganglia;Gastrin releasing peptide;Gene Expression;Genetic;Heterogeneity;Homeostasis;Hypoxia;In Situ Hybridization;in vivo;Induced Neurons;Interoception;Irritants;Knowledge;Label;Lung;Mediating;Medical;Molecular;Mus;Nervous System Disorder;neural;neural circuit;Neural Pathways;neuromechanism;Neurons;neuropathology;novel;novel therapeutics;Nucleus solitarius;optogenetics;Organ;Outcome;Panic Disorder;particle;Pathologic;Pathway interactions;Pattern;Peripheral;Peripheral Nervous System;Pharmacotherapy;Phase;Phobias;Physiological;Play;Population;Post-Traumatic Stress Disorders;Process;Research;Respiratory physiology;response;RNA;Role;segregation;Seizures;sensory stimulus;Signal Transduction;single molecule;single-cell RNA sequencing;Sleep Apnea Syndromes;Specificity;Stimulus;Sudden infant death syndrome;Synapses;Tachykinin;Techniques;Testing;transcriptome;Viral;Visceral;Work

PROJECT_TITLE: Dissecting neural circuits for breathing patterns


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WASHINGTON

ORG_NAME: AMERICAN SOCIETY FOR MICROBIOLOGY

ORG_STATE: DC

PHR: Project Narrative Minoritized students represent a growing pool of students traditionally underrepresented in biomedical and behavioral sciences, and the changing demographics of the U.S. will require their increased participation. The Annual Biomedical Research Conference for Minority Scientists (ABRCMS) provide these students with the opportunity to develop as scientists and share their research via in person and virtual presentation platforms and successfully transition to graduate or professional training programs. In addition, ABRCMS provides faculty advisers, research scientists, and program director with resources for facilitating student success.

PI_NAMEs: AUGUST, AVERY ;HULEDE, IRENE VERONICA (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: Address;American;Area;Behavioral Sciences;Biomedical Research;career;career development;Career Mobility;Communication;Competence;Country;demographics;design;Development;Discipline;Disparity;doctoral student;Education;Engineering;Ethics;Exhibits;experience;Exposure to;Faculty;Feedback;Fostering;Funding;Goals;graduate school;graduate student;Graduation Rates;high school;Institution;Learning;lectures;matriculation;meetings;Mentors;Microbiology;Minority Groups;minority scientist;minority student;minority undergraduate;Names;Oral;parity;peer;Persons;Population;posters;Process;programs;Recording of previous events;recruit;Research;Resources;responsible research conduct;Role;Science;Scientific Societies;Scientist;Series;skills;Societies;STEM student;Students;success;symposium;Training;Training Programs;undergraduate student;United States National Institutes of Health;virtual;webinar;Work

PROJECT_TITLE: Annual Biomedical Research Conference for Minority Scientists - Cycle 5

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


PI_NAMEs: BARRINGTON-TRIMIS, JESSICA LOUISE (contact)

PROJECT_TERMS: addiction;Address;Adolescent;Adolescent and Young Adult;Age;Area;Automobile Driving;Behavior;California;Characteristics;cohort;Cohort Studies;combustible tobacco;computerized data processing;Data;Data Analyses;Dependence;design;Dose;Electronic cigarette;electronic cigarette use;emerging adult;Frequencies;Fruit;gender minority status;Genus Mentha;health disparity;high risk;high school;Hybrids;Ice;Longitudinal cohort study;low socioeconomic status;marginalization;marginalized population;Marketing;Measures;Menthol;Modeling;Names;Nicotine;nicotine use;ninth grade;novel;Oral;Outcome;Participant;Pattern;Policies;Population;Population Heterogeneity;preference;programs;progression risk;Prospective cohort;Prospective, cohort study;recruit;Regulation;Research;Rewards;Risk;Role;Schools;Science;Sexual and Gender Minorities;sexual minority status;Smoking;socioeconomics;Surveys;Symptoms;synergism;Testing;Time;Tobacco;tobacco flavor;tobacco products;Tobacco use;twelfth grade;vaping;young adult;Youth

PROJECT_TITLE: Project 2


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Pancreatic cancer is a disease of near uniform lethality and early diagnosis, preferably at an asymptomatic stage, represents the best chance of improving long term prognosis of patients. The objective of this Gulf Coast-Great Lakes EDRN Clinical Validation Center (GCGLEC) is to collect the highest quality annotated biospecimens, including from populations typically underrepresented in biomarker studies, in order to facilitate biomarker validation in early stage pancreatic cancer, as well as in at-risk and pre-diagnostic cohorts. As an EDRN funded validation center, collaborative endeavors within the network will be an integral component of the GCGLEC.

PI_NAMEs: MAITRA, ANIRBAN  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Address;Area;Autoantibodies;Benign;Biological Markers;biomarker panel;biomarker validation;Blinded;CA-19-9 Antigen;Cancer Center;Cancer Detection;chronic pancreatitis;circulating biomarkers;Clinical;cohort;Collaborations;Collection;Cyst;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;disparity gap;Early Detection Research Network;Early Diagnosis;Endocrine Gland Neoplasms;Environment;ethnic minority;Family;Foundations;Funding;Gastroenterology;General Population;Germ-Line Mutation;Goals;gulf coast;Health;Health system;high risk;Hospitals;Hyperglycemia;Image;improved;improved outcome;Individual;industry partner;Institution;Joints;Leadership;Letters;Malignant - descriptor;Malignant neoplasm of pancreas;Mucinous;Operative Surgical Procedures;Pancreas;Pancreatic Cyst;Pancreatic cystic neoplasia;Pancreatic Diseases;Pancreatic Ductal Adenocarcinoma;Parents;Pathology;patient prognosis;patient subsets;Patients;Phase;phase 3 study;phase 4 study;Population;prospective;Prospective cohort;protein biomarkers;Proteins;Public Health;Publications;Publishing;racial minority;Recording of previous events;recruit;Research;Research Activity;Research Design;Research Personnel;Risk;Sampling;screening;Sensitivity and Specificity;Site;Specificity;Tissue Inhibitor of Metalloproteinase-1;Translating;Tumor Antigens;Underrepresented Minority;United States;Unresectable;Validation;validation studies

PROJECT_TITLE: Clinical Validation Center for Early Detection of Pancreatic Cancer


ORG_CITY: VALLEY CENTER

ORG_NAME: INDIAN HEALTH COUNCIL, INC.

PHR: PROJECT NARRATIVE Indian Health Council, Inc., in collaboration the University of California San Diego, San Diego State University, California State University San Marcos and the Pacific Institute for Research and Evaluation, proposes to support the research efforts of the NARCH XII projects:  • ACEs Aware: Indigenizing Trauma-Informed Care in Clinical Practice  • CHAIN Community Health through Analysis of Internal Numbers  • IHC HPV-Associated Cancer Prevention Project  • Examination of Evolving Opioid Misuse and Overdose Risk Among American Indi- ans The projects aim to address critical issues in the local tribal communities with innovative and timely strategies. They aim to incorporate AIAN community stakeholder perspectives into core elements of practice, thus indigenizing approaches that can move the fields of trauma informed care, cancer prevention, opioid care, and population health to better serve American Indians.

PI_NAMEs: CALAC, DANIEL J. (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Address;Alaska Native;American;American Indians;Awareness;California;cancer prevention;career;Caring;Cervical Cancer Screening;Clinic;clinical practice;Collaborations;Communication;Communities;Community Actions;community based research;community engagement;Community Health;Development;electronic health data;Elements;Epidemic;Evaluation;evidence base;Funding;Goals;Health;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Individual;innovation;institutional capacity;Institutional Review Boards;Intervention;Methods;Mission;Modeling;Native American Research Center for Health;Opioid;opioid misuse;opioid overdose;opioid use;overdose death;overdose risk;Patients;population health;Prevention;Readiness;Research;Research Institute;Research Project Grants;Research Support;Risk;screening;stakeholder perspectives;Structure;Students;tool;Training;Trauma;tribal community;tribal Nation;Tribes;Universities;Vaccination;Work

PROJECT_TITLE: Native American Research Centers For Health (NARCH XII)


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE This project will use intracranial electroencephalography (iEEG) to characterize the effects of sevoflurane anesthesia on intra-operative phase-amplitude coupling and effective connectivity, and it will determine whether this modulation can identify seizure foci and predict seizure outcomes, during resective surgery for pediatric drug-resistant focal epilepsy. Creating normative atlases of these iEEG-derived metrics will provide critical reference by illuminating the human brain’s endogenous neurophysiology landscape under varying concentrations of sevoflurane. Clinically, establishing inducible tools for intra-operative localization of epileptic brain regions is expected to reduce diagnostic burden, optimize treatment cost effectiveness, avoid the complications associated with extra-operative mapping, facilitate more accurate resection margins, and ultimately lead to better seizure outcomes.

PI_NAMEs: FIRESTONE, ETHAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: 3-Dimensional;Anatomy;Anesthesia procedures;Anesthetics;Area;Atlases;Biological Markers;Brain;Brain imaging;Brain region;brain tissue;career;Child;Childhood;Clinical;Cognitive deficits;Cohort Studies;Consumption;cost effectiveness;Coupling;Critical Thinking;Data;Development;Diagnostic;Drug resistance;Electrodes;Electroencephalography;Entropy;Epilepsy;Ethics;Etiology;Evaluation;Event;Excision;FDA approved;Fellowship;Fostering;Foundations;Grant;High Frequency Oscillation;Human;implantation;improved;indexing;insight;Intervention;Intractable Epilepsy;Isoflurane;Lesion;Logistics;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measurement;Measures;Medical;Michigan;Modeling;neural;neurophysiology;Observational Study;Operating Rooms;Operative Surgical Procedures;Outcome;Partial Epilepsies;Pathway interactions;Patients;Pediatric Hospitals;pediatric patients;Pediatric Surgical Procedures;Phase;Physicians;Postoperative Period;Procedures;Process;prospective;Protocols documentation;Proxy;Regimen;repository;Research;Research Design;Resected;Risk Factors;Risk Reduction;Scientist;Seizures;sevoflurane;Signal Transduction;Site;Slow-Wave Sleep;Specificity;standard care;success;Techniques;Testing;Time;tool;tractography;Training;Travel;treatment optimization;Visual;Visualization;Volatilization;white matter

PROJECT_TITLE: Intraoperative Localization of Epileptic Brain Regions Under Sevoflurane Anesthesia.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F01A-V(20)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Substance Misuse

PHR: Calac-CORE CA-NARCH XII Project Narrative  Project Narrative  The overall goals of the CA-NARCH Administrative Core are to support the research efforts of  the NARCH XII projects and to provide critical ongoing community-based participatory tribal  direction. The CA-NARCH Administrative Core aims to 1) provide administrative, fiscal, and  management direction and oversight to the CA-NARCH XII research projects; 2) coordinate  communication among the proposed projects and between the proposed projects and the tribal  communities; 3) To provide guidance to proposed projects in evaluation planning; and 4)  increase the institutional profile of the CA-NARCH through representation on Community  Advisory Boards for local academic or research institutions.

PROJECT_TERMS: Address;Alaska Native;American Indians;cancer prevention;career;Caring;Communication;Communities;community advisory board;community based research;Development;Elements;Evaluation;evidence base;Funding;Goals;Health;Human Papilloma Virus-Related Malignant Neoplasm;innovation;Institution;Institutional Review Boards;Mission;Modeling;Native American Research Center for Health;Opioid;population health;Research;Research Project Grants;Research Support;stakeholder perspectives;Structure;Students;Trauma;tribal community;tribal Nation;Tribes;Work

PROJECT_TITLE: NARCH XII-Admin CORE

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-N]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with about 50,000 new cases and 45,000 deaths every year. Whereas new therapeutics have increased the overall survival rate of cancer patients in general, these improvements are rarely seen in PDAC, emphasizing the need for new therapeutic targets. Because endoplasmic reticulum-to-mitochondria transfer of calcium is required for cancer cell survival, we propose to use animal and cell-culture models to identify the role of this process in the development and metastasis in pancreatic cancer, anticipating that this may lead to treatments that significantly improve patient outcomes for this highly lethal disease.

PI_NAMEs: FOSKETT, JAMES KEVIN (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Ablation;Acute;advanced disease;American;Animal Model;Animals;anti-cancer;anti-cancer therapeutic;Autophagocytosis;Biochemical;Bioenergetics;Biological;Biological Assay;biophysical techniques;Biophysics;Calcium;calcium uniporter;cancer cell;Cancer cell line;Cancer Patient;cancer therapy;Cause of Death;Cell Culture Techniques;Cell Line;Cell Survival;cell type;Cells;Cellular Metabolic Process;Cessation of life;Citric Acid Cycle;CRISPR/Cas technology;Cytoplasm;Dependence;designer receptors exclusively activated by designer drugs;Development;Diagnosis;Disease;Early Diagnosis;Early identification;Electrophysiology (science);Endoplasmic Reticulum;epithelial to mesenchymal transition;falls;Fibroblasts;Future;Gel;Gene Modified;Genetic;Genetic Models;genetic predictors;genetically modified cells;Growth;Homeostasis;Human;Immune response;improved;In Vitro;in vivo;innovation;Interruption;Invaded;Ion Channel;ITPR1 gene;Life;live cell imaging;Luciferases;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Membrane;Metabolic;Metabolism;Methods;migration;Mitochondria;Modeling;Molecular;Morphology;Motility;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;new therapeutic target;NOD/SCID mouse;Normal Cell;novel;novel therapeutics;Organelles;Oxidoreductase;Oxygen Consumption;Pancreatic Adenocarcinoma;pancreatic cancer patients;pancreatic cell line;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patient-Focused Outcomes;Patients;Permeability;Pharmaceutical Preparations;pharmacologic;Play;Process;Prognosis;Proliferating;Property;Proteins;Regulation;Renal Carcinoma;Reporter Genes;response;Role;Signal Transduction;Site;Survival Rate;System;Tail;targeted treatment;Technology;Therapeutic;therapeutic target;three-dimensional modeling;tumor;tumor progression;tumorigenesis;tumorigenic;uptake;Veins;Work

PROJECT_TITLE: Endoplasmic Reticulum-to-Mitochondria Calcium Transfer in Pancreatic Cancer Development, Metastasis, and Treatment

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


PI_NAMEs: MONTEROSSO, JOHN R (contact)

PROJECT_TERMS: absorption;abuse liability;addiction;Address;Adolescent;Affinity;Age;aged;Area;Behavior;Behavioral;behavioral economics;career;Categories;cisgender;computerized data processing;Data;Data Analyses;design;Dose;Electronic cigarette;electronic cigarette use;electronic cigarette user;Equity;Evaluation;experience;Flavoring;follow-up;Fruit;gender minority group;Genus Mentha;Health;Heterosexuals;improved;indexing;Intake;Intention;interest;irritation;Marketing;Masks;Measures;Menthol;Modeling;Motivation;Nicotine;Nicotine Dependence;nicotine gum;nicotine use;novel;Oral;Oral cavity;Oral Characters;Oral Examination;oral irritation;Participant;Pattern;Persons;Pharmaceutical Preparations;Predisposition;prevent;Randomized;recruit;Regulation;residence;Rewards;Sampling;Science;Self Administration;Sensory;Sexual and Gender Minorities;Standardization;Surveys;Testing;Tobacco;Tobacco use;vaper;vaping;virtual;virtual laboratory;Visit;Vulnerable Populations;willingness;Withdrawal;Work;young adult

PROJECT_TITLE: Project 3


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE This program brings together highly respected scientists with expertise ranging from epidemiology and biostatistics to molecular aspects of tobacco control to determine why lung cancer risk from cigarette smoking is significantly different among five diverse ethnic/racial groups. The multidisciplinary team in this program follows this important lead to determine new approaches toward prevention of lung cancer, the leading cancer killer in the U.S.

PI_NAMEs: HECHT, STEPHEN S (contact)

PROGRAM_OFFICER_NAME: SIMONDS, NAOKO ISHIBE

PROJECT_TERMS: 1,3-Butadiene;4 hydroxynonenal;Acetylcysteine;Acrolein;addiction;Adult;African American population;American Cancer Society;Aromatic Polycyclic Hydrocarbons;Automobile Driving;Biochemical;Biochemistry;Biological;Biological Markers;Biometry;Biostatistics Core;Cancer Center;Cancer Etiology;cancer risk;carbonyl compound;carcinogenesis;Carcinogens;catalyst;Cessation of life;Chemistry;Chronic;Cigarette;Cigarette Smoker;cigarette smoking;Clinical;Cohort Studies;Collaborations;design;Deuterium;Disease;DNA Damage;DNA Methylation;enzyme activity;Epidemiology;epigenetic marker;Epigenetic Process;ethnic difference;ethnic diversity;Ethnic Population;experience;exposure to cigarette smoke;former smoker;Frequencies;Genetic;Genetic Markers;genetic variant;Goals;Hemoglobin;high risk;improved;Incidence;Individual;Inflammation;Inflammatory Response;Inhalation;insight;Japanese American;Label;Latino Population;Lead;Linoleic Acids;Lipid Peroxidation;Lung;lung cancer prevention;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;men;Metabolic;Metabolic Activation;Metabolism;Methodology;Molecular;Molecular Epidemiology;Molecular Epidemiology of Cancer;mortality statistics;multi-ethnic;multidisciplinary;Native Hawaiian;never smoker;Nicotine;novel;novel strategies;Persons;phenanthrene;Phenols;Prevention;Prevention approach;Productivity;Program Research Project Grants;programs;racial difference;racial population;Relative Risks;Research;Research Personnel;response;Risk Marker;Scientist;Smoke;Smoker;Smoking;smoking cessation;statistics;tobacco carcinogenesis;tobacco control;Tobacco smoke;Tobacco-Associated Carcinogen;Tobacco-Related Carcinoma;urinary;Urine;Variant;Woman

PROJECT_TITLE: Mechanisms of Ethnic/Racial Differences in Lung Cancer Due to Cigarette Smoking


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cervical Cancer;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Sexually Transmitted Infections;Substance Misuse;Vaccine Related;Women's Health Research

PHR: PROJECT NARRATIVE  Cervical cancer is the most frequently diagnosed cancer in American Indian/Alaska Native  (AI/AN) women, who are nearly twice as likely to develop cervical cancer compared to non-  Hispanic white (NHW) women and four times as likely to die from it. While implementation  strategies and relevant evidence-based interventions (EBIs) exist to increase screening, few  have been tested in AI/AN populations. Furthermore, few health care settings have adopted  these EBIs, and their evaluation is limited. AI/ANs cite a number of barriers to cancer screening  including cultural reluctance to access Western medicine for non-acute health problems;  transportation difficulties; lack of childcare; and negative perception of health providers.  Enabling factors, however, include access to female health professionals (including Indigenous  health workers), and locally devised health plans that aim to improve access, health provider  knowledge, recall systems, targeted culturally relevant health promotion, and population  registers. Similarly, low HPV vaccination rates among Native communities call for locally and  culturally relevant information and education efforts. Recent studies suggest that low-cost,  targeted, multipronged approach[es] may be effective in Native communities to increase both  vaccination and screening rates, and emphasize the importance of indigenous leadership in  both cancer prevention planning and promotion within the community. This is consistent with  recommendations by the US Community Preventive Service Task Force (USCPSTF) for  multicomponent (individual demand, provider delivery, access) and multilevel (i.e., patient,  provider, health system) EBIs.  To address this gap, we propose to use Implementation Science to assess the implementation  and effectiveness of the existing cervical cancer screening strategies and EBIs in a community  health center serving AI/AN patients.

PI_NAMEs: NODORA, JESSE  (contact)

PROJECT_TERMS: 12 year old;Address;Adolescent;Adopted;Advisory Committees;Alaska Native;Alaska Native population;Alaska Native Women;American Indian Population;American Indian Women;American Indians;Anus;Attention;California;Cancer Center;cancer diagnosis;cancer prevention;Caring;cervical cancer prevention;Cervical Cancer Screening;Cervix Uteri;Child;Child Care;Client;Clinical;Communities;community engaged research;cost;County;Data;Development;Education;Effectiveness;effectiveness evaluation;Elements;Enabling Factors;Ensure;Evaluation;evidence base;Evidence based intervention;Female;Future;Goals;Health;health care settings;Health Personnel;health plan;Health Professional;Health Promotion;Health Resources;Health system;Healthcare;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;implementation evaluation;implementation science;implementation strategy;implementation study;Improve Access;Incidence;Indigenous;Individual;innovation;Intervention;Knowledge;Leadership;male;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Medicine;men;Mexico;National Cancer Institute;Native American Research Center for Health;Neighborhood Health Center;Not Hispanic or Latino;Oropharyngeal;Patients;penis;Perception;Population Registers;preventable death;Prevention strategy;Preventive service;Probability;programs;Provider;provider intervention;Public Health Practice;Randomized;Recommendation;Reporting;Research;screening;Screening for cancer;Services;Site;System;Testing;Transportation;treatment as usual;Tribal Council;Tribes;Underserved Population;Vaccination;vaccine trial;Vagina;Vulva;White Women;Woman;Women's Health

PROJECT_TITLE: HPV Cancer Prevention Project


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: Aurora

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative  Platelet-derived growth factor (PDGF) signaling has been shown to regulate numerous processes throughout the body, both during development and adult life, and aberrant PDGF signaling has been causally associated with defects in craniofacial development, cancer, vascular disorders and fibrotic diseases. Defects in craniofacial development comprise one of the most prevalent birth defects in humans, with an estimated incidence in the United States of 1/940 live births for cleft lip and 1/1,574 live births for cleft palate. The studies proposed here will provide valuable insight into the mechanisms underlying craniofacial development by characterizing dimerization, activation, trafficking and signal molecule binding dynamics for PDGFRa/b heterodimers, which may contribute to the development of new therapeutic directions for the treatment of human craniofacial birth defects.

PI_NAMEs: CAMPANA, MARIA B (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Ablation;Adult;Alleles;Binding;Biological;Biological Assay;bone;C-terminal;Cartilage;Cell Line;cell motility;Cleft Lip;cleft lip and palate;Cleft Palate;Complement;Complex;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial development;craniofacial structure;Defect;Development;dimer;Dimerization;Disease;Embryo;Endosomes;experimental study;Face;Fluorescence;Fluorescence Microscopy;Frozen Sections;Genes;Goals;Human;Immunoprecipitation;In Vitro;in vivo;Incidence;Individual;innovation;insight;knock-down;Knock-in;Laboratories;Life;Ligands;Ligation;Live Birth;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Mesenchyme;Molecular;Mus;Mutation;N-terminal;nanobodies;Neural Crest Cell;novel;novel therapeutics;osteoblast differentiation;Outcome Study;overexpression;palatal shelves;Phosphorylation;Plasmids;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor alpha Receptor;platelet-derived growth factor BB;Platelet-Derived Growth Factor Receptor;Play;Pregnancy;Process;Proliferating;Proteins;Proteomics;receptor;Recycling;Repression;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Skeleton;Small Interfering RNA;spatiotemporal;Specificity;stable cell line;Syndrome;Terminator Codon;Testing;Tissues;trafficking;Transfection;United States;Vascular Diseases;Venus;Western Blotting

PROJECT_TITLE: Characterization of PDGFR alpha/beta heterodimers

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: AA

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Project Narrative: Alcohol tolerance is a key factor leading to increased consumption and subsequent alcohol abuse and alcoholism. Our goal is to understand, at the molecular level, the adaptations that occur in response to alcohol exposure that underlie tolerance and its compounding effects on disorders of addiction. In this project we will explore a key regulated process triggered during rapid ethanol exposure resulting in persistent changes in neuronal intrinsic plasticity and its impact on voluntary alcohol consumption. !

PI_NAMEs: VELAZQUEZ, CRISTINA M. (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Acute;addiction;Adolescent;Alcohol abuse;Alcohol consumption;alcohol exposure;alcohol response;alcohol sensitivity;Alcoholism;Alcohols;Behavioral;Behavioral Assay;beta catenin;binge drinking;Brain region;Calcium;cancer cell;Cell membrane;Cell Nucleus;Chemosensitization;comparative;Consumption;Corpus striatum structure;Coupled;Cytoplasm;Data;desensitization;Development;Disease;Dissociation;drinking behavior;Electrophysiology (science);Elements;Event;Goals;hippocampal pyramidal neuron;Hour;Human;Image;Imaging Techniques;in vitro Model;in vivo;Invertebrates;Ion Channel;Knock-out;Knockout Mice;Knowledge;large-conductance calcium-activated potassium channels;Learning;Link;Mammals;Measures;Mediating;Membrane;Memory;Mental Depression;Messenger RNA;MicroRNAs;Modeling;Molecular;Molecular Biology;Monitor;Mus;Names;neuronal excitability;Neuronal Plasticity;Neurons;new therapeutic target;Nucleus Accumbens;overexpression;Pathway interactions;Play;preference;Preparation;prevent;Process;Protein Biosynthesis;Protein Isoforms;Publishing;Regulation;Research;resilience;response;Role;Signal Pathway;Signal Transduction;Slice;Surface;Synaptic plasticity;System;Testing;trafficking;Transcriptional Activation;Transgenic Mice;Up-Regulation;Variant;voltage;Withdrawal

PROJECT_TITLE: MiR-9 regulation of beta-catenin mediated alcohol tolerance and EtOH consumption

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

PHR: Project Narrative  The rapidly evolving opioid epidemic requires public health responses that continuously adjust  to the changing crisis, particularly for American Indian Tribes who often receive little attention  but endure the largest burden of opioid overdose. This community-based study will generate  results to help Tribes make informed decisions that can lead to the development of sustainable  programs to decrease opioid misuse and overdose risk.

PI_NAMEs: GAINES, TOMMI LYNN (contact)

PROJECT_TERMS: addiction;Address;Adult;Affect;Age;Alaska Native;Alaska Native population;American Indian community;American Indian Population;American Indian Tribe;American Indians;Area;Attention;Back;California;Chairperson;Communities;Community Actions;community engagement;community intervention;community partners;Country;COVID-19 pandemic;Cross-Sectional Studies;Data;diverse data;drug market;Drug usage;Emergency department visit;Environment;Epidemic;Ethnic Population;Etiology;experience;Fatality rate;Geographic Locations;Geography;Goals;Harm Reduction;Health;health care availability;health equity;Heroin;Hospitalization;Illicit Drugs;Indian reservation;Individual;Interview;Medical Examiners;medication-assisted treatment;Morphologic artifacts;mortality;naloxone dispensing;National Institute of Drug Abuse;Native American Research Center for Health;Opioid;opioid epidemic;opioid misuse;opioid mortality;opioid overdose;opioid use;opioid use disorder;Overdose;overdose death;overdose risk;Pattern;Pharmaceutical Preparations;pill;Population;prescription opioid;prescription opioid misuse;Prevention;prevention service;Program Sustainability;programs;Public Health;racial population;Reaction Time;Reporting;Research;Research Methodology;Resources;response;Risk;Services;social;Social isolation;Source;Strategic Planning;surveillance data;Surveys;Sustainable Development;synthetic opioid;Time;tool;treatment services;trend;Tribes;United States;Work

PROJECT_TITLE: Examination of evolving opioid misuse and overdose risk among American Indians


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NEW YORK

ORG_NAME: VA  MEDICAL CENTER

ORG_STATE: NY

PHR: We aim to improve the medical care and well being of the millions of Veterans who have hearing loss. We hope to demonstrate that providing simple, low cost hearing assistance during Emergency Department visits can help patients to understand what they must do to take care of themselves after they leave the ED. Better understanding could result in improved health outcomes and lower healthcare costs for older Veterans with hearing loss and could translate beyond VA to the many more millions of Americans who are also affected.

PI_NAMEs: CHODOSH, JOSHUA  (contact)

PROJECT_TERMS: Acceleration;Accident and Emergency department;Acute;Address;Admission activity;Affect;Age;Age Years;Aging;American;Bilateral;Caring;Clinical;clinical encounter;Clinical Medicine;Code;combat;Communication;Communication difficulty;comorbidity;Consent;cost;Devices;disability;Disabling;Elderly;Emergency Care;Emergency Department patient;Emergency department visit;Environment;Equipment and supply inventories;Goals;group intervention;Health;Health Care Costs;Health Services Accessibility;Healthcare;Healthcare Systems;Hearing;Hearing Aids;hearing disability;hearing impairment;hearing screening;Home;Hospitalization;Hospitals;human old age (65+);improved;Instruction;Intervention;Interview;Knowledge;Measures;Medical;medical attention;Mental Health;New York;Noise;noise exposure;normal hearing;Nurses;older adult;older patient;Older Population;Outcome;Patient Outcomes Assessments;Patient Self-Report;Patients;Personal Satisfaction;Pharmaceutical Preparations;physical conditioning;Physicians;point of care;Population;Preparation;provider communication;Quality of Care;Questionnaires;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Reporting;Research;Risk;screening;sound;Speech;Structure;Surveys;Symptoms;Testing;Time;Translating;treatment as usual;Triage;United States Department of Veterans Affairs;Veterans;Vietnam;Visit;willingness

PROJECT_TITLE: Hearing Impairment, Strategies and Outcomes in VA Emergency Departments

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE While smoking cessation reduces risk of lung cancer, former smokers remain at higher risk of disease compared to never smokers. To help control lung cancer in a population that has already taken a major step to decrease risk, this project seeks to identify genetic, epigenetic and biochemical predictors of lung cancer risk. Findings from this study may provide information that may be used for targeted strategies in lung cancer prevention and screening.

PI_NAMEs: PARK, SUNGSHIM LANI (contact)

PROJECT_TERMS: Accounting;Address;age related biomarkers;Biochemical;Biochemical Markers;Biological;Biological Markers;Cadmium;cancer diagnosis;Cancer Etiology;cancer health disparity;cancer risk;cell type;Cessation of life;cigarette smoking;Cohort Studies;Collaborations;Complement;computed tomography screening;Cross-Sectional Studies;CYP1A1 gene;Data;Data Reporting;Death Rate;disorder risk;Disparate;DNA Methylation;Dose;Epigenetic age;epigenetic marker;Epigenetic Process;epigenome;epigenome-wide association studies;Equity;ethnic difference;Ethnic Origin;Ethnic Population;European ancestry;Evolution;former smoker;Frequencies;Funding;Genetic;Genetic Markers;genetic variant;Genetic Variation;genome wide association study;Heterogeneity;high risk;high risk population;Histologic;improved;Incidence;Individual;Individual Differences;insight;Leukocytes;Light;low dose computed tomography;lung cancer prevention;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Measures;men;Methylation;molecular marker;mortality;multi-ethnic;never smoker;never smoking;Nicotine;Participant;Patient Self-Report;Pattern;phenanthrene;Population;prospective;Race;racial difference;racial minority;racial population;response;Risk;Risk Marker;risk prediction model;Risk Reduction;screening;screening guidelines;sex;Site;Smoker;Smoking;smoking cessation;smoking exposure;Smoking History;Testing;Time;urinary;Variant;Woman

PROJECT_TITLE: Genetic and epigenetic risk markers for lung cancer in former smokers


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: The nation’s opioid crisis has led to a series of policies within the VA designed to reduce the risk of opioid overdose and misuse. While these policies address an important public health problem, it is not known whether Veterans with serious illness may be experiencing unintended consequences of these well-intentioned policies and guidelines. Veterans with end-stage renal disease (ESRD) have very limited life expectancy and high rates of uncontrolled pain. They are at increased risk of opioid-related adverse events, but have fewer non-opioid analgesic alternatives and may face barriers to non-pharmacologic therapies. This novel project will examine how the VA’s opioid policies have affected the treatment of Veterans with ESRD over the past decade, with a focus on important outcomes including pain management approaches, uncontrolled pain, and adverse events. This project will yield important insights into the healthcare experiences of 35,000 Veterans with ESRD, with the overall goal of improving the quality of pain management for this high-risk population.

PI_NAMEs: WACHTERMAN, MELISSA  (contact)

PROJECT_TERMS: Address;advanced disease;Adverse effects;Adverse event;Affect;Analgesics;Area;Back;care fragmentation;Caring;Clinical;clinical care;Collaborations;Communities;Community Healthcare;Complex;Data;Data Sources;Delirium;design;Development;Dialysis procedure;Disseminated Malignant Neoplasm;Distress;End stage renal failure;Ethics;experience;Face;falls;Frequencies;Future;Goals;Guidelines;Health Priorities;Healthcare;high risk population;implementation strategy;improved;innovation;insight;Interruption;Intervention;Interview;Kidney;Life Expectancy;Link;Medicare;member;Methodology;Methods;military veteran;non-opioid analgesic;Nonpharmacologic Therapy;novel;Opioid;opioid epidemic;opioid misuse;opioid overdose;opioid policy;opioid use;Outcome;Overdose;Pain;Pain management;Pain Measurement;Pain quality;Palliative Care;Patients;Pharmaceutical Preparations;pharmacy benefit;Policies;policy implication;Population;Practice Guidelines;Practice Management;prescription opioid;programs;Public Health;Recommendation;Research;Research Design;Risk;Risk Reduction;Safety;Series;Serious Adverse Event;Structure;Symptoms;Testing;Time;Time Series Analysis;trend;uptake;Veterans;Vulnerable Populations;Work

PROJECT_TITLE: Optimizing Pain Management in End-Stage Renal Disease Among Veterans (OPERA-Vets):Balancing Benefits and Harms of Opioids


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Surgery can precipitate the development of both chronic pain and long-term opioid use. There is a need for strategies to augment perioperative pharmacotherapeutic management of pain with non-pharmacologic strategies to prevent long-term sequelae. Psychological interventions such as cognitive behavioral therapy (CBT) can effectively reduce distress and improve functioning among patients with chronic pain. While CBT has been used extensively in patients with established chronic pain, it has not been used as a preventive intervention targeting the transition from acute to chronic postsurgical pain. The Perioperative Pain Self- management (PePS) program has the potential to reduce the incidence of chronic post-surgical pain and long- term opioid use among Veterans. This study will: 1) Examine the efficacy of PePS compared to standard care on 6-month pain, mood and functioning outcomes as well as time to post-surgical opioid and other analgesic use cessation, and 2) Elucidate the context for subsequent implementation.

PI_NAMEs: HADLANDSMYTH, KATHERINE E. (contact);MOSHER, HILARY

PROJECT_TERMS: Acute;Address;Affect;Analgesics;Anxiety;Area;arm;Arthritis;biopsychosocial;Caring;Chronic;chronic pain;chronic pain management;chronic pain patient;Cities;Clinic;Clinical;Cognitive;Cognitive Therapy;comorbidity;Coping Skills;cost;cost estimate;Data;design;Development;Disease;Dissemination and Implementation;Distress;efficacy evaluation;evidence base;experience;follow-up;functional improvement;future implementation;General Population;Goals;Guidelines;Healthcare Systems;Human Resources;Hybrids;implementation context;implementation design;implementation outcomes;implementation strategy;improved;Incidence;innovation;Intervention;Interview;Iowa;Joints;Logistic Regressions;long-term sequelae;Managed Care;Measures;member;Methodology;microcosting;Modeling;Moods;non-opioid analgesic;Nurses;Operative Surgical Procedures;Opioid;opioid overuse;opioid use;Orthopedic Surgery;Outcome;Pain;pain catastrophizing;pain chronification;Pain management;pain reduction;pain self-management;Participant;Patients;Perioperative;Pharmaceutical Preparations;pharmacologic;pilot trial;Postoperative Pain;Postoperative Period;prescription pain reliever;prevent;Prevention;preventive intervention;primary endpoint;primary outcome;Procedures;Process;Protocols documentation;psychologic;psychological distress;Randomized;Randomized, Controlled Trials;Records;Relaxation;Replacement Arthroplasty;Reporting;Research;Risk;Risk Factors;Schedule;secondary outcome;sedative;Self Efficacy;self-management program;Severities;Single-Blind Study;Site;skills;standard care;Substance Use Disorder;Surgeon;Survival Analysis;Telephone;telephone session;Thinking;Time;treatment arm;treatment effect;trial design;uptake;Veterans;Work

PROJECT_TITLE: Preventing Chronic Post-Surgical Pain and Prolonged Opioid Use: The Perioperative Pain Self-Management Program


ORG_CITY: HERSHEY

ORG_DEPT: PEDIATRICS

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Narrative Autophagy is an intracellular recycling process where crescent-shaped membranes expand around cellular material and seal to form a double-membrane vesicle known as the autophagosome. While we recently identified the components that seal these membranes to allow for efficient recycling, how the components are targeted to the membrane is unknown, and we seek to elucidate this process. Understanding this mechanism is important for human health, as autophagy regulates the cellular response to stress and is dysregulated in many human diseases, including neurodegeneration, cancer, heart disease, liver disease, and aging.

PI_NAMEs: WANG, HONG-GANG  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Aging;ATP phosphohydrolase;Autophagocytosis;Autophagosome;Binding;Biogenesis;Biological Assay;Cell membrane;Cellular Membrane;Complex;CRISPR/Cas technology;Cytokinesis;Cytoplasm;Data;Defect;Disease;Electron Transport Complex III;Elements;Endosomes;Event;Excision;Family member;Genes;genome-wide;Goals;Growth;Health;Heart Diseases;Homologous Gene;Human;human disease;Knowledge;Libraries;Lipids;Liver diseases;Lysosomes;Malignant Neoplasms;Mammalian Cell;Mediating;Membrane;membrane model;Modeling;Molecular;N-terminal;Nerve Degeneration;novel;Nuclear Envelope;Pathologic Processes;Peptide Initiation Factors;Physiological Processes;Positioning Attribute;Process;Protein Databases;Protein Family;protein function;Proteins;Proteomics;receptor;recruit;Recycling;repaired;response;Role;seal;Shapes;Site;Sorting;spatiotemporal;Stress;Structure;Tertiary Protein Structure;Testing;Text;TSG101 gene;Ubiquitin;Ubiquitination;Variant;Vesicle;Work

PROJECT_TITLE: Autophagosome closure by the ESCRT machinery

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BALTIMORE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative: Overuse of diagnostic testing in hospitalized adults is an important contributor to unsustainably high healthcare costs and also has harmful effects on individual patients. Methods to identify hospitals with high levels of diagnostic intensity, potentially associated with diagnostic overuse, are lacking. I propose to (1) perform a systematic review of published studies evaluating hospital-level diagnostic overuse, (2) use a hospital-level diagnostic intensity index, with hospital claims data from the Medicare program, to identify hospitals with high levels of diagnostic intensity, and (3) evaluate the relationship between diagnostic intensity and quality of care, specifically missed diagnoses.

PI_NAMEs: ELLENBOGEN, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Developing and refining methods to measure hospital-level diagnostic intensity, identify outlier hospitals, and characterize the relationship between diagnostic intensity and missed diagnoses

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PHR: NARRATIVE A smoker's nicotine metabolism efficiency can influence their lung cancer risk. This is driven by variation in the activity of the enzyme CYP2A6. In this grant we will develop a CYP2A6 genetic score to predict CYP2A6 activity in ever smokers and then determine the association of the score with lung cancer risk.

PI_NAMEs: MURPHY, SHARON E (contact)

PROJECT_TERMS: African American;African American population;Alleles;Base Sequence;Biological Markers;Calibration;cancer risk;Carcinogens;Case/Control Studies;catalyst;Cigarette;cigarette smoking;cohort;Conversion disorder;Cotinine;CYP2A7 gene;CYP2D6 gene;Data;Diagnosis;disorder risk;Dose;environmental tobacco smoke exposure;enzyme activity;ethnic difference;ethnic disparity;Ethnic Population;former smoker;Funding;Gene Conversion;Genes;Genetic;genetic predictors;genetic variant;Genetic Variation;genome wide association study;Genotype;Goals;Grant;Hybrids;hydroxycotinine;improved;Individual;Individual Differences;Japanese American;Low Prevalence;Malignant neoplasm of lung;Measures;Mediating;Metabolic;Metabolism;multi-ethnic;Native Hawaiian;Nicotine;Phenotype;Population;Prevalence;Prevention strategy;Pseudogenes;Race;racial difference;racial disparity;racial population;Relative Risks;Research;Risk;Role;sequencing platform;Smoke;Smoker;Smoking;targeted sequencing;Tobacco;United States;Variant

PROJECT_TITLE: CYP2A6 genetic score, nicotine metabolism and lung cancer


PI_NAMEs: UNGER, JENNIFER BETH (contact)

PROJECT_TERMS: Adolescent;Affect;Area;Authorization documentation;base;Behavior;California;Candy;career;Cartoons;Characteristics;Code;combustible cigarette;computerized data processing;Curiosities;Data;Data Analyses;Data Collection;Descriptor;design;Development;digital;Electronic cigarette;Emerging Tobacco Products;experimental study;Exposure to;Fostering;Health Benefit;High School Student;Human;Image;Instagram;Intention;Manufacturer;Marketing;Measures;Mediating;Methods;Modeling;Modernization;Monitor;Names;Nicotine;nicotine use;nicotine user;novel;Oral;Oral Examination;Patient Self-Report;peer influence;Perception;Predisposition;Procedures;promoter;recruit;Regulation;Reporting;response;Sampling;Schools;Science;Smoking;social engagement;social media;social norm;Source;Stimulus;Strawberries;Surveys;Tablets;Techniques;Terminology;Testing;TikTok;Tobacco;tobacco advertising;tobacco exposure;tobacco flavor;tobacco products;Tobacco use;training opportunity;trend;Twitter;United States National Institutes of Health;warning label;Work;young adult;Youth

PROJECT_TITLE: Project 4


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PHR: NARRATIVE Although smoking is a recognized risk factor for lung cancer, 14% of Americans continue to smoke. About 11-24 % of smokers will develop lung tumors over the lifetime, with a greater cancer incidence in African American and Native Hawaiian cigarette smokers as compared with European Americans, Japanese Americans, and Latinos. Our studies will conduct comprehensive exposome analyses to help provide insight into the origins of this variability in sensitivity to smoking-mediated lung cancer and help identify individuals at risk who should be candidates for special smoking cessation intervention or chemopreventive therapy.

PI_NAMEs: TRETYAKOVA, NATALIA Y (contact)

PROJECT_TERMS: 1,3-Butadiene;Acceleration;adduct;African American;African American population;Alcohol consumption;American;Bioinformatics;Biological;Biology;Blood;Butadiene;cancer health disparity;cancer risk;Carcinogens;Cell Separation;Cells;Chemicals;Chemopreventive Agent;cigarette smoke;Cigarette Smoker;cigarette smoking;cohort;Complex;Complex Mixtures;Development;Diet;dietary;Disease;Disparity;DNA;DNA Adducts;DNA Damage;DNA lesion;DNA Repair;DNA Repair Inhibition;environmental chemical;Environmental Exposure;environmental tobacco smoke exposure;epidemiology study;Epigenetic Process;Erythrocytes;Ethics;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;European;Excretory function;Exercise;exposed human population;Exposure to;exposure to cigarette smoke;Fire - disasters;former smoker;Genetic;Genomics;Globin;Goals;gut microbiota;Half-Life;Health;Hemoglobin;high risk;Human;human disease;improved;Incidence;Individual;Individual Differences;Induced Mutation;Inflammatory;Inflammatory Response;innovation;insight;Japanese American;Latino;Latino Population;Libraries;Life Style;lifestyle factors;Lipid Peroxidation;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;metabolomics;Methodology;microbiome;Microsomes;Molecular;Molecular Epidemiology;Monitor;multi-ethnic;N-terminal;Native Hawaiian;never smoker;non-smoker;novel;Occupational;Outcome;Oxidative Stress;Oxidative Stress Induction;Peptides;Pharmaceutical Preparations;Physiological;Play;Population;Predisposition;Prevention strategy;Preventive therapy;Process;Proteins;Proteomics;Race;racial difference;racial disparity;racial population;Research;response;Risk;Risk Factors;Role;Smoke;Smoker;Smoking;Smoking Cessation Intervention;Source;System;Testing;Time;transcriptomics;urinary;Variant

PROJECT_TITLE: Untargeted Adductomics to Characterize Ethnic Differences in the Exposome of Smokers


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes;Eye Disease and Disorders of Vision;Genetics;Nanotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Wound Healing and Care

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Relevance of the proposed research project to public health The application addresses PA-19-056 goal as a Research Project Grant on new ways of treating stem cell and wound healing defects in diabetic corneal disease. We will focus on normalizing human diabetic corneal epithelial stem cells, which are the source of corneal surface lining, through the action of a new diabetic corneal marker Wnt5a that accelerates wound healing, as well as through gene therapy blocking Wnt5a inhibition with innovative non-toxic and biodegradable nano polymer conjugate. If successful, the proposal may have a high impact for future treatment of frequent wound healing-related corneal problems in diabetic patients.

PI_NAMEs: LJUBIMOV, ALEXANDER V (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Age;antagonist;Antineoplastic Agents;bead chip;Binding;biomarker identification;Blindness;Cathepsins;cell motility;Cell Proliferation;Cells;Combined Modality Therapy;Complications of Diabetes Mellitus;Cornea;Corneal Diseases;corneal epithelial stem cells;corneal epithelial wound healing;corneal epithelium;Decitabine;Defect;demethylation;Deoxycytidine;Development;Diabetes Mellitus;diabetic;diabetic patient;Diagnosis;Disease;DNA;DNA Methylation;effective therapy;efficacy testing;Epigenetic Process;epigenetic regulation;Epithelial Cells;epithelial stem cell;epithelial wound;Epithelium;Eye;Eye diseases;Family;Future;Gene Abnormality;Gene Expression;gene therapy;Genes;Goals;Growth;Human;Hypermethylation;Image;Impaired wound healing;Impairment;improved;inhibitor;innovation;Iris;Keratopathy;lens;limbal;MAP3K7 gene;MAPK4 gene;MCAM gene;Mediating;member;Memory;Metabolic;Methods;Methylation;MicroRNAs;Molecular Mechanisms of Action;Motility;nano;Nanoconjugate;nanodrug;nanopolymer;nanotherapy;Nature;Neuropathy;Normal Cell;novel;Operative Surgical Procedures;Organ Culture Techniques;Pain;Pathway interactions;Phenotype;Phosphorylation;Population;Prediction of Response to Therapy;Process;Proliferating;protein expression;Proteins;Public Health Applications Research;receptor;Recurrence;Research Project Grants;restoration;Retina;ROR1 gene;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Small Interfering RNA;Source;stem cell biomarkers;stem cell population;stem cells;stromelysin 2;Surface;System;Testing;Therapeutic;Tissues;Transplantation;Treatment Efficacy;Ulcer;Viral;Vision research;Visual impairment;WNT5A gene;WNT5A protein;wound healing;Zebularine

PROJECT_TITLE: Wnt5a, a New Diabetic Corneal Marker Related to Wound Healing


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Tobacco;Tobacco Smoke and Health

PHR: NARRATIVE Former smokers remain at high risk for lung cancer even 25 years after quitting yet little is known about the biochemical mechanisms leading to lung cancer in former smokers. This project investigates the hypothesis that exposure to ubiquitous environmental carcinogens can be very damaging to former smokers because of particles and other changes in their lungs and that chronic inflammation in former smokers is also involved in their high cancer susceptibility. Specific chemical biomarkers will be used to test these theories.

PROJECT_TERMS: 4 hydroxynonenal;4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;Acetylcysteine;Acrolein;adduct;alpha Tocopherol;Aromatic Polycyclic Hydrocarbons;Bay Region;Biochemical;Biological Markers;biomarker identification;black lung;C-reactive protein;Cancer Etiology;cancer risk;carbonyl compound;carcinogenesis;carcinogenicity;Cells;Chemicals;Chronic;cigarette smoking;Clinic;Clinical Research;Cohort Studies;CYP1A1 gene;Cytochromes;Data;DNA;DNA Adducts;DNA Damage;Dose;Environmental Carcinogens;Epoxy Compounds;ethnic difference;Exposure to;former smoker;Glycols;high risk;IL8 gene;Inflammation;Inflammatory;Inhalation;Inhalation Drug Administration;innovation;insight;Interleukin-6;Label;Leukocytes;Linoleic Acids;Lipid Peroxidation;Lung;lung cancer prevention;Malignant neoplasm of lung;Malignant Neoplasms;Metabolic;Metabolic Activation;multi-ethnic;never smoker;non-smoker;Oral;oxidative damage;Oxidative Stress;Participant;particle;Pathway interactions;Peroxidases;phenanthrene;Phenols;Plasma;Pleural;potential biomarker;Predisposition;Process;Production;Progress Reports;Prostaglandins;Pulmonary Inflammation;Questionnaires;racial difference;recruit;Relative Risks;Risk;Sampling;Serum;Smoker;Smoking;smoking cessation;Testing;theories;Toxic effect;toxicant;Tumor Promotion;urinary;Urine;Volatilization

PROJECT_TITLE: Carcinogenesis biomarkers in former smokers of the Multi Ethnic Cohort Study


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE Given the prevalence of obesity in the United States, understanding how neuroendocrine signals mediate the impact of food experiences on consumption is an important step in the development of approaches for treating diseases of maladaptive ingestive behavior. To this end, we propose to investigate the role of brainstem glucagon-like peptide-1 (GLP-1) in underlying the suppressed consumption of a recently eaten food. Furthermore, we aim to characterize the role of two brainstem inputs to understand how the effects of GLP-1 signaling can be modulated to promote overconsumption.

PI_NAMEs: APPLEBEY, SARAH  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acute;Affect;Agonist;Amygdaloid structure;Anatomy;antagonist;Brain;Brain Stem;Calories;Cell Nucleus;Cells;comparative;Consumption;Data;designer receptors exclusively activated by designer drugs;Development;Disease;Eating;Environment;experience;experimental study;Exposure to;feeding;Feeding behaviors;Food;food consumption;Gastrointestinal tract structure;GLP-I receptor;glucagon-like peptide 1;hedonic;hindbrain;Incentives;Injections;Intake;Mediating;Modeling;Modernization;motivated behavior;Motivation;Mus;neural;neuromechanism;Neurons;Neurosecretory Systems;novel;Obesity;Peripheral;Play;Population;Positioning Attribute;preproglucagons;Prevalence;prevent;Rattus;reduced food intake;Rewards;Role;Satiation;Sensory;Signal Transduction;Site;source localization;Structure;Structure of terminal stria nuclei of preoptic region;Testing;Time;United States;Virus

PROJECT_TITLE: Role of glucagon-like peptide-1 signaling in mediating sensory-specific satiety


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Tobacco;Tobacco Smoke and Health

PROJECT_TERMS: Advisory Committees;Analytical Biochemistry;Biometry;Biostatistics Core;California;Cancer Center;cancer risk;cigarette smoking;Collaborations;Communication;data quality;Ensure;Epidemiology;equity, diversity, and inclusion;ethnic difference;ethnic diversity;experience;Goals;Government;Grant;Hawaii;Laboratories;Lead;lung cancer prevention;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Manuscripts;Mass Spectrum Analysis;meetings;Minnesota;Molecular;multidisciplinary;National Cancer Institute;novel strategies;Office of Administrative Management;operation;Persons;Policies;Preparation;Prevention;Principal Investigator;professor;Program Research Project Grants;programs;Progress Reports;Publications;PubMed;quality assurance;racial difference;racial population;Regulation;Reporting;Research;Research Personnel;Resource Sharing;Scientist;Sexual Harassment;Specialist;symposium;tobacco control;United States National Institutes of Health;Universities;Videoconferencing;virtual

PROJECT_TITLE: Core A. Administrative Core A


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE Senescence cells accumulate with age and are thought to contribute to age-related diseases. Here, we propose to comprehensively map senescent cells in high resolution in the human heart and lung. We will use multi-modal, high-content, and high-throughput approaches in whole tissues, organ slices, and isolated cells in order to characterize and map the senescent cell population, identify the relevant endogenous triggers for senescent cell formation, and delineate the specific senescent cell properties that modulate the response to senolytic therapy.

PI_NAMEs: FINKEL, TOREN  (contact);KOENIGSHOFF, MELANIE ;MORA, ANA LUCIA;RAHMAN, IRFAN

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Address;Age;age-related disease;Area;ATAC-seq;Atlases;Benchmarking;Biochemical;Biological;Biological Assay;Biological Markers;Biology;Body System;Cardiac Myocytes;Cell Aging;Cell Cycle;Cell Cycle Arrest;Cell Proliferation;Cell Separation;cell type;Cells;cellular targeting;chromatin remodeling;Collaborations;Communication;computerized data processing;Consent;Data;Data Analyses;detection sensitivity;Dimensions;DNA Damage;Elderly;empowerment;Exhibits;experience;Experimental Animal Model;Fingerprint;Functional disorder;functional outcomes;Generations;Goals;Health;healthy aging;Heart;Heterogeneity;high throughput analysis;Human;human tissue;Image;Impairment;In Situ;Individual;Infrastructure;innovation;innovative technologies;Institution;Joints;Knowledge;large datasets;Leadership;Learning;Link;Lung;Maps;Medical center;medical schools;Mitochondria;Mitotic;Modeling;Molecular;Molecular Profiling;Morphology;multimodality;Mutation;Neonatal;Neurons;novel;Ohio;Oncogenes;Organ;Oxidative Stress;Phenotype;Physiological;Population;postmitotic;Procedures;Prognosis;programs;Property;Proteomics;proteotoxicity;Research;Research Personnel;Resolution;Resources;response;RNA;Sampling;secretory protein;senescence;senescent cell;senolytics;Slice;Standardization;Stimulus;Stress;synergism;Technology;telomere;Therapeutic;Tissue atlas;tissue mapping;tissue processing;Tissue Sample;Tissues;tool development;transcriptomics;treatment response;tumor;United States National Institutes of Health;Universities;Vision;Withdrawal

PROJECT_TITLE: TriState SenNET (Lung and Heart) Tissue Map and Atlas consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(70)R]


ADMINISTERING_IC: HL

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC

ORG_STATE: TN

PHR: PROJECT NARRATIVE Sickle Cell Disease (SCD) is a painful inherited blood disorder with significant early mortality that affects millions of people worldwide. Hematopoietic stem cell (HSC) transplantation remains the only curative therapy; however, little is known about how the HSC bone marrow niche health could be impacting transplantation recovery and success, and how damage to the bone marrow niche by SCD pathophysiology contributes to post-transplant complications. This work will be an important first step to understanding how transcriptional dysfunction in SCD MSCs influences HSC support, which could ultimately have implications for improved success of SCD curative therapies.

PI_NAMEs: CAIN, TERRI  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acute Myelocytic Leukemia;Adult;Affect;Antibodies;ATAC-seq;Automobile Driving;B-Lymphocytes;Bioinformatics;Blood Vessels;Bone Marrow;Bone Marrow Diseases;Candidate Disease Gene;career;Cell Compartmentation;Cell Cycle;Cell Physiology;Cell Proliferation;Cell Separation;Cells;Chromatin;chromatin protein;Chronic;Cleavage Under Targets and Release Using Nuclease;Coculture Techniques;curative treatments;cytokine;Data;differential expression;Disease;Down-Regulation;Early identification;Epigenetic Process;Functional disorder;Gene Expression Profile;gene repression;Gene set enrichment analysis;Gene Structure;Genes;Genetic Transcription;Goals;Health;Hematological Disease;Hematology;Hematopoietic;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobin;hemoglobin polymer;Hemoglobinopathies;Hemolysis;Hemolytic Anemia;Human;I-Cell Disease;Immunoglobulin G;Impairment;improved;in vivo;Individual;Inflammation;Inflammatory;Inherited;innovation;Institution;knock-down;Lead;life span;mesenchymal stromal cell;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;nuclease;Ontology;Organ;overexpression;Pain;Patients;Persons;Phenotype;Pilot Projects;Population;post-transplant;Principal Investigator;Proliferating;Recovery;retroviral transduction;Sickle Cell Anemia;Small Interfering RNA;Stress;success;Supporting Cell;SWI/SNF Family Complex;System;Techniques;Testing;Tissues;transcription factor;Transcription Factor 3;translational impact;Transplantation;United States National Institutes of Health;Up-Regulation;Vertebrates;Work

PROJECT_TITLE: Investigating dysregulation of hematopoietic stem cell support in sickle cell disease mesenchymal stromal cells


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Phthalates are among the most ubiquitous endocrine disrupting chemicals and the widespread exposure poses a risk to pregnant women, a group more sensitive to insults from environmental agents than the general population; however, evidence is limited and inconsistent regarding phthalate metabolites’ effect on maternal gestational weight gain (GWG) and fetal growth trajectories. The primary goal of this research proposal is to use innovative, theory-driven methods to explore associations and highlight the interpretability of phthalate metabolites’ effect on maternal GWG and fetal growth patterns among a diverse group of healthy pregnant women across the United States. The knowledge expected from the proposed study can provide opportunities to design interventions to reduce exposure levels, implement policies to regulate phthalate concentrations in products and, educate and target women at greatest risk of exposure.

PI_NAMEs: SIDDIQ, SHABNAZ  (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: advanced analytics;analytical method;Asian Women;Biological Process;Biometry;Birth Weight;black women;Body Weight;career;Chemicals;Classification;cohort;Complex Mixtures;critical period;Data;Development;Disparity;Education;Endocrine;Endocrine Disruptors;Ensure;Environment;environmental agent;environmental chemical;Environmental Exposure;Epidemiology;Epigenetic Process;Equation;ethnic disparity;Ethnic Origin;Ethnic Population;Exposure to;Failure;fetal;Fetal Development;Fetal Growth;flexibility;General Population;Genetic;gestational weight gain;glucose metabolism;Goals;Gonadal Steroid Hormones;Growth;Health;healthy pregnancy;Hispanic Women;Hormonal;Immunity;Individual;innovation;insulin sensitivity;Intervention;Kilogram;Knowledge;Life Cycle Stages;lipid metabolism;Literature;Longevity;Maternal and Child Health;maternal obesity;maternal outcome;maternal weight;Measures;Metabolism;Methodology;Methods;Mission;Modeling;Modification;Mothers;National Institute of Environmental Health Sciences;Nested Case-Control Study;Not Hispanic or Latino;Nulliparity;obesity in children;Outcome;Oxidative Stress;Participant;Pattern;personal care products;phthalates;Placenta;Placentation;Plastics;Policies;Population Heterogeneity;Pregnancy;Pregnancy Outcome;Pregnancy Trimesters;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;Productivity;Proxy;Race;racial difference;racial disparity;racial diversity;racial population;Regulation;Reproduction;Research;Research Personnel;Research Proposals;Risk;sex;skills;Socioeconomic Factors;Specific qualifier value;Statistical Methods;Sum;Testing;theories;therapy design;Time;Training;United States;Universities;urinary;Woman;Work

PROJECT_TITLE: Prenatal exposure to phthalates and associations with gestational weight gain and fetal growth trajectories.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE The purpose of the Clinical Trial and Biomarker Core is to conduct the clinical trials and collect biological samples for Project 2-4 and analyze biomarkers of exposure and potential harm for all Projects proposed in this P01.

PI_NAMEs: HATSUKAMI, DOROTHY K (contact)

PROJECT_TERMS: 2-butenal;4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;Acetylcysteine;Acrolein;African American population;alpha Tocopherol;Biological;Biological Markers;biomarker panel;Blood;blood-based biomarker;Cadmium;caucasian American;cigarette smoking;Clinical;clinical biomarkers;clinical implementation;Clinical Research;clinical trial participant;clinical trial recruitment;Clinical Trials;cohort;Collection;Conduct Clinical Trials;cost;cost effective;Cotinine;Data;Dose;Erythrocytes;ethnic difference;Ethnic Origin;Ethnic Population;Exposure to;former smoker;Genetic;Genotype;Goals;Hawaii;Hour;Human Resources;IL8 gene;Individual;Inflammation;Inflammatory;Inhalation;Inhalation Drug Administration;Interleukin-6;Japanese American;Laboratories;Linoleic Acids;Malignant neoplasm of lung;Measures;Metabolic;Metabolism;Minnesota;multi-ethnic;Native Hawaiian;never smoker;Nicotine;non-smoking;Not Hispanic or Latino;Oral;Oral Administration;Oxidative Stress;Participant;Pathway interactions;Patient Recruitments;Peroxidases;phenanthrene;Plasma;Procedures;Program Research Project Grants;programs;propylene oxide;Race;racial difference;racial population;recruit;Research;Risk;Running;sample collection;Sampling;Services;Site;Smoker;smoking cessation;Stable Isotope Labeling;Time;Tobacco;Training;urinary;Urine;Variant

PROJECT_TITLE: Core B. Clinical & Biomarkers Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Narrative This is an established training program to foster the development of academic surgical oncologists. This program meets an important public health need as the population ages and the number of cancer patients increases. Trainees from this program will become leaders in surgical oncology to enhance cancer research and patient care.

PI_NAMEs: JERUSS, JACQUELINE SARA;ZOU, WEIPING  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Michigan;Research Training;Surgical Oncology;Training Programs;Universities

PROJECT_TITLE: University of Michigan Surgical Oncology Research Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Tobacco;Tobacco Smoke and Health

PHR: NARRATIVE The Biostatistics Core uses advanced state-of-the art computing techniques to analyze the extensive and complex sets of data that are generated in this Program Project. These analyses enhance our understanding of the interplay between genetic and environmental effects leading to new insights for prevention of lung cancer.

PI_NAMEs: STRAM, DANIEL O (contact)

PROJECT_TERMS: Biostatistics Core;cancer risk;case control;cigarette smoking;Complex;Computer software;Data;Data Analyses;data integration;data management;Data Security;Data Set;Databases;design;Development;DNA analysis;DNA Methylation;Doctor of Philosophy;epigenome-wide association studies;ethnic difference;Ethnic Origin;Genetic;insight;Lead;lung cancer prevention;Malignant neoplasm of lung;Methodology;Methods;Modeling;Outcome;Procedures;Program Research Project Grants;programs;Quality Control;racial difference;Relative Risks;Smoking;Statistical Data Interpretation;Statistical Methods;Survival Analysis;Techniques

PROJECT_TITLE: Core C. Biostatistics Core


ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PI_NAMEs: LEVENTHAL, ADAM MATTHEW (contact)

PROJECT_TERMS: Address;Advisory Committees;Applications Grants;Award;base;career;Collaborations;Communication;community engagement;Community Outreach;Complement;data sharing;Development;Digital Libraries;Doctor of Philosophy;Electronic Mail;Ensure;Evaluation;Expenditure;Face;Faculty;Fostering;Funding;General Population;Goals;Human Resources;Individual;Leadership;Marketing;Measures;meetings;member;Mentors;Methodology;Methods;Mission;Modeling;Monitor;novel;Persons;Pilot Projects;Policies;Press Releases;Process;Productivity;Program Evaluation;programs;Publications;Recommendation;Regulation;Reporting;Research;Research Personnel;Resources;response;Science;Series;social media;Strategic Planning;success;Supervision;synergism;System;theories;Time;Tobacco;tobacco products;tobacco regulatory science;Traumeel S;trend;United States National Institutes of Health;web site;working group

PROJECT_TITLE: USC Tobacco Center of Regulatory Science


NIH_SPENDING_CATS: Aging

PI_NAMEs: FINKEL, TOREN  (contact)

PROJECT_TERMS: Biological;Biological Assay;Cells;Collaborations;Communication;Consent;Data;Data Analyses;Data Collection;data sharing;Development;Ensure;Environment;Fostering;Funding;Goals;Heart;Heterogeneity;Human;Human BioMolecular Atlas Program;Individual;Infrastructure;innovation;Institution;Leadership;life span;Logistics;Lung;Maps;Medical center;meetings;Occupational activity of managing finances;Ohio;operation;Participant;Personnel Management;Pilot Projects;Policies;Procedures;programs;Protocols documentation;Research;Research Personnel;Research Project Grants;Resolution;Science;senescent cell;Site;success;synergism;Tissue atlas;tissue mapping;Tissues;Training;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Admin Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE – OVERALL The Center of Innovation for Brain Tumor Therapeutics will bring together a multi-disciplinary team of basic, translational and clinical scientists to develop highly effective treatment for patients with glioblastoma (GBM).

PI_NAMEs: BINDRA, RANJIT ;GALANIS, EVANTHIA ;SARKARIA, JANN N. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Adjuvant;Aftercare;Animal Model;animal tissue;Biological Assay;Biopsy;Biotechnology;Brain;Brain Neoplasms;cancer therapy;cerebral microvasculature;chemotherapy;Clinic;Clinical;clinical development;clinical translation;cohort;Collaborations;combinatorial;Communities;Cytotoxic Chemotherapy;Data;Development;DNA Damage;drug distribution;drug efficacy;Drug Exposure;Drug Targeting;effective therapy;Evaluation;Excision;Fostering;Funding;Genomic Instability;genotoxicity;Glioblastoma;Glioma;Goals;Grant;Heterogeneity;Human;human tissue;Impairment;Infiltration;inhibitor;innovation;Investigation;Laboratories;Leadership;Manuscripts;Medical Oncology;member;Modeling;Molecular;multidisciplinary;neoplastic cell;neuro-oncology;neurosurgery;New Drug Approvals;Normal tissue morphology;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;outreach;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Substance;Pharmacology;Physicians;Population;pre-clinical;Preclinical Testing;Productivity;Publishing;Radiation;Radiation Oncology;Radiation therapy;Recurrence;Research;research clinical testing;response;Risk;routine therapy;Sampling;Scientist;small molecule;Structure;Systems Biology;temozolomide;Testing;Therapeutic;therapeutically effective;Therapy Evaluation;therapy resistant;tool;Translating;Translational Research;translational study;Treatment Failure;tumor;Tumor Biology;tumor heterogeneity;Tumor Tissue;tumorigenesis;United States National Institutes of Health;Work


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Pediatric;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE More than half of the estimated tuberculosis (TB) disease cases in children worldwide have not been reported to the health system, and 96% of pediatric TB deaths are in children not started on treatment. The proposed project seeks to address the key barriers in diagnosing pulmonary TB in children through discovery of a host proteomic biosignature in urine. The findings will be relevant to the public health efforts to reduce the burden of TB in children and will support the development of a non-invasive, non-sputum based assay for childhood TB disease at the point-of-care.

PI_NAMEs: JAGANATH, DEVAN  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: accurate diagnosis;Address;Adult;Age;Bioinformatics;Biological Assay;Biological Markers;biomarker discovery;biomarker panel;biomarker validation;biosignature;Blood;California;candidate marker;career;career development;Cessation of life;Child;Child Care;Childhood;Clinical;cohort;Consensus;Coupling;Data;Dedications;Development;Diagnosis;Diagnostic;Diagnostic tests;Disease;disease phenotype;Enrollment;Environment;Evaluation;experience;Funding;Gene Expression;Gene Expression Profile;Goals;Health system;Hospital Referrals;Human;Immune response;Immunoassay;improved;Infection;Infrastructure;International;Machine Learning;Mass Spectrum Analysis;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;mortality;multidisciplinary;Mycobacterium tuberculosis;Nested Case-Control Study;novel;novel marker;Pathogenesis;Pathway Analysis;Pathway interactions;Performance;Physicians;point of care;point of care testing;Post-Translational Protein Processing;pre-clinical;prospective;Prospective cohort;protein biomarkers;Proteins;Proteome;Proteomics;Public Health;Pulmonary Tuberculosis;Reporting;Reproducibility;Research;research and development;Research Personnel;Resources;Role;sample collection;Sampling;San Francisco;Scientist;Shotguns;Site;Specificity;Sputum;Testing;tool;Training;Translating;Triage;Tuberculosis;Tuberculosis diagnosis;Uganda;United States National Institutes of Health;Universities;Urine;Work

PROJECT_TITLE: Host Proteomic Biosignatures for a Urine-based Diagnosis of Pulmonary Tuberculosis in Children

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease;Lung

PI_NAMEs: ROJAS, MAURICIO  (contact)

PROJECT_TERMS: Age;Aging;beta-Galactosidase;biobank;Biological;Biological Assay;Blinded;Bronchoalveolar Lavage;Cell Line;Cell Separation;Cells;Classification;Clinical;Collection;Consent;Data;Data Analyses;Dimensions;Drug or chemical Tissue Distribution;Ensure;Environmental Exposure;Ethics;Evaluation;Exclusion;Exhibits;experimental study;global health;Goals;Health;Heart;Heart Diseases;heart function;Heterogeneity;high throughput analysis;Histologic;Histology;Histopathology;Human;Human body;human tissue;Immune;Immunofluorescence Immunologic;Individual;Infection;Inferior;Institutional Review Boards;interoperability;Ischemia;Label;Legal;life span;Lung;Lung Diseases;lymph nodes;Maps;Medical center;Metadata;Morbidity - disease rate;Morphologic artifacts;mortality;multimodality;Nature;Ohio;Organ;Pathologic;Pathology;Phase;Population;Procedures;Process;Proteomics;Protocols documentation;pulmonary function;Quality Control;Reagent;Research;Research Personnel;Resolution;Resources;Sampling;senescence;senescent cell;single-cell RNA sequencing;Site;Slice;Specimen;Technology;Tissue atlas;Tissue Banks;tissue mapping;tissue processing;Tissue Procurements;Tissue Sample;Tissues;transcriptomics;Trauma;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: Biospecimen-Core


PI_NAMEs: WIPFLI, HEATHER L (contact)

PROJECT_TERMS: Academia;Active Learning;authority;Award;career;career development;Catalogs;certificate program;cohort;community engagement;Community Outreach;Data;Databases;design;Development Plans;Educational Curriculum;Educational workshop;Ensure;equity, diversity, and inclusion;Ethnic Origin;evidence base;Evolution;experience;Faculty;faculty community;Fellowship;Funding;Funding Opportunities;Gender;Goals;Government;Grant;health equity;Immersion;Individual;innovation;insight;Institution;Instruction;interdisciplinary approach;interest;Leadership;Learning;manufacture;Marketing;meetings;member;Mentors;Mentorship;Methodology;Monitor;Morbidity - disease rate;mortality;Nature;next generation;Performance;Persons;Population Heterogeneity;Postdoctoral Fellow;pre-doctoral;Predisposition;Public Health;Public Speaking;Publications;Race;recruit;Regulation;Research;Research Ethics;Research Personnel;Research Project Grants;Resources;satisfaction;Science;Scientist;skills;social;Students;symposium;Tobacco;tobacco control;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;Training;Training Activity;University of Southern California Norris Cancer Center;working group;Writing

PROJECT_TITLE: Career Enhancement Core


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Black pregnant people are disproportionately impacted by trauma in their lifetime, which has been associated with significantly increased risk for maternal morbidity and mortality. The proposed study aims to understand the physiologic mechanisms by which trauma may contribute to disparities in labor complications through epigenetic changes. Knowledge gained from this study will advance science in the fields of trauma, epigenetics, and pregnancy with the objective of identifying modifiable risk factors for labor complications that could be tested for clinical treatments and prevention approaches to reduce racial disparities in pregnancy- related morbidity/mortality.

PI_NAMEs: BRITT, ABBY  (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: allostatic load;Area;Biological;biological adaptation to stress;Birth;Black Populations;Black race;Blood specimen;Caring;Cesarean section;Childbirth;Clinical;Clinical Treatment;cohort;Country;Data;Death Rate;design;Disparity;DNA Methylation;early pregnancy;Epigenetic Process;epigenome;epigenome-wide association studies;Event;Exhibits;experience;Fellowship;Functional disorder;Genes;Genome;genome-wide;Geographic Locations;Grant;Human;hypothalamic-pituitary-adrenal axis;Income;Inflammatory Response;insight;Knowledge;Labor Complications;Life;Life Cycle Stages;Link;Live Birth;maternal morbidity;Maternal Mortality;maternal risk;maternal stress;Measurement;Medical Records;Mental disorders;methylation pattern;Modeling;modifiable risk;Modification;Morbidity - disease rate;mortality;National Research Service Awards;Nurse Midwives;Outcome;Parents;Participant;Pathway interactions;Perinatal;Perinatal Care;perinatal outcomes;Persons;Physiological;Physiology;poor health outcome;Population;Pregnancy;Pregnancy Outcome;pregnancy related death;pregnant;prenatal;Prevention approach;Prospective cohort;racial disparity;Reporting;Research;response;Risk;Risk Factors;Sampling;Science;Scientist;severe maternal morbidity;social health determinants;Stress;Surveys;System;Testing;theories;Third Pregnancy Trimester;Training;Trauma;trauma exposure;United States

PROJECT_TITLE: Prenatal Epigenetics: Trauma and Outcomes of Labor Dysfunction

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(86)]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: We propose to use plane wave ultrafast ultrasound imaging to detect blood flow imaging of choroidal and retinal vessels under electrical stimulation. We further propose to build a high frequency 15-20 MHz 2D array driven by Verasonic system. The proposed technology can potentially provide such a clinical tool.

PI_NAMEs: CHEN, SHIGAO ;ZHOU, QIFA  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;3D ultrasound;Adoption;Affect;Age;Aging;aging population;Algorithms;American;Angiography;Area;Blindness;Blood;Blood flow;Blood Vessels;Brain;Calibration;California;Characteristics;Circulation;Clinic;Clinical;clinical application;clinical imaging;clinical practice;Color;Contrast Media;density;Development;Disease;Doppler Effect;Doppler Ultrasound;elastography;Electric Stimulation;experience;Eye;Fluorescein Angiography;Frequencies;Gender;Generations;Glaucoma;Head;Image;imaging system;Imaging technology;improved;in vivo;interest;Lead;Maps;Measurement;medical schools;Methods;Microbubbles;Microcirculation;Microscopy;Modality;Morphology;neural;novel;Ophthalmologist;Ophthalmology;Optic Disk;Optical Coherence Tomography;optical imaging;Optics;Oryctolagus cuniculus;Patient Care;Patients;Penetration;Perfusion;Persons;Physiologic Intraocular Pressure;Posterior eyeball segment structure;Primary Open Angle Glaucoma;Quantitative Evaluations;Race;radiologist;recruit;Research;Research Personnel;Resolution;Resources;retina blood vessel structure;retinal imaging;Risk Factors;risk stratification;Role;Scanning;Scientist;Sclera;Site;Speed;Subgroup;success;superresolution imaging;System;Techniques;Technology;Tissues;tool;two-dimensional;ultra high resolution;Ultrasonic Transducer;Ultrasonic wave;Ultrasonics;Ultrasonography;ultrasound;United States National Institutes of Health;Universities;Visualization

PROJECT_TITLE: High-Resolution Flow Imaging of Optic Nerve Head and Retrolaminar Microvascular Circulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: BAR-JOSEPH, ZIV  (contact)

PROJECT_TERMS: Agreement;artificial intelligence algorithm;Atlases;Bioinformatics;Biological;Biological Assay;Biological Markers;biomedical informatics;Biometry;Cell Aging;Cells;Clinical Sciences;Collaborations;Computational Biology;computational intelligence;computational pipelines;computer science;Data;Data Analyses;Data Collection;Data Coordinating Center;data harmonization;data integrity;data quality;Data Set;data standards;Database Management Systems;Databases;design;Doctor of Philosophy;Elements;Ensure;experience;Goals;Health Sciences;Heart;Human;Image;imaging modality;Informatics;Institution;Lung;Machine Learning;Maps;Medical center;metadata standards;Methods;mid-career faculty;Modeling;Multiomic Data;Ohio;open data;Procedures;Process;professor;programs;Public Health;quality assurance;Quality Control;Research;Resource Sharing;senescence;synergism;System;three-dimensional modeling;Tissue atlas;tissue mapping;Tissues;Translational Research;Universities;Validation;Work

PROJECT_TITLE: Data-Analysis-Core