NIH_SPENDING_CATS: Asthma;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Lung;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

PHR: PROJECT NARRATIVE Asthma is a severe chronic illness in childhood triggered by viral infections and with significant racial disparities. To examine how exposure to social stress is linked to pathophysiology of the disease, we use high-resolution epigenetic approaches at population and single-cell level to reveal epigenetic changes in immune cells predicting antiviral response and development of asthma.

PI_NAMEs: GRUNDBERG, ELIN  (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: Acute;adverse childhood events;Affect;African American;Age;Anti-viral Response;Asthma;asthma exacerbation;asthma prevention;Biological;Biological Assay;Blood;Blood specimen;Cell model;cell type;Cells;Child;Childhood;Childhood Asthma;Chronic;Chronic Disease;Chronic stress;cohort;Collection;Cross-Sectional Studies;Data;Development;Diagnosis;Disease;Disease susceptibility;Disparity;DNA methylation profiling;Elements;Enrollment;Environment;Environmental Exposure;environmental stressor;epigenetic marker;Epigenetic Process;epigenetic profiling;epigenome;epigenomics;ethnic disparity;ethnic minority population;experience;Exposure to;Extrinsic asthma;Functional disorder;Gene Expression;gene function;Gene Targeting;Genes;Genetic;Goals;health disparity;health disparity populations;Heterogeneity;Hispanic;Immune;immune function;Immune system;Impairment;In Vitro;in vitro Model;Infection;Inflammatory;Inflammatory Response;insight;Intervention;Laboratories;late life;Life;Life Style;Link;Lung Diseases;Macrophage;Maps;Measures;Mediating;Methylation;methylome;Modification;monocyte;Morbidity - disease rate;multidisciplinary;Myelogenous;Nose;Not Hispanic or Latino;novel strategies;Nucleic Acid Regulatory Sequences;Pathway interactions;Patients;Pattern;Pediatric cohort;Phenotype;Play;Population;population based;predictive marker;Predisposition;Prevalence;programs;prospective;Psychosocial Factor;Psychosocial Stress;racial discrimination;racial disparity;racial minority population;Regulatory Element;Resolution;Resources;respiratory;response;Rhinovirus;Rhinovirus infection;Risk;Role;Sampling;Scientist;Severities;Signal Pathway;Signal Transduction;social;social disparities;Social Environment;social stress;Stress;stressor;Structure of mucous membrane of nose;Testing;Tissue Sample;Tissues;transcriptome;transcriptomics;Untranslated RNA;Up-Regulation;Validation;Variant;Viral;Virus Diseases

PROJECT_TITLE: Understanding Mechanisms Underlying Chronic Stress-Induced Asthma in Children by Population and Single-Cell Epigenomics Approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(55)R]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE During cell division, each daughter cell should receive one copy of each replicated chromosome, a process that requires functional centromeres and when failed has broad medical implications including infertility, birth defects and tumor development. Importantly, centromeres are not determined by a specific DNA sequence, but rather depend on a DNA-protein complex. Our goals here are to understand how human centromeres function and the molecular mechanisms that prevent failure of normal chromosome delivery and the subsequent broad effects on genome instability.

PI_NAMEs: NECHEMIA-ARBELY, YAEL  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Aging;Base Pairing;Binding;cancer type;Cell Cycle;Cell division;Cell Line;Cell Proliferation;Centromere;centromere protein A;centromere protein C;ChIP-seq;Chromatin;Chromosome Arm;chromosome replication;Chromosome Segregation;Chromosomes;Cleavage Under Targets and Release Using Nuclease;Complex;Congenital Abnormality;Data;Data Set;Daughter;daughter cell;Deposition;Development;DNA;DNA biosynthesis;DNA Methylation;DNA Sequence;Epigenetic Process;epigenomics;Excision;Failure;Foundations;Future;Genome;Genomic Instability;Genomics;Goals;Histone H3;Histones;Human;Infertility;innovation;interest;Maintenance;Malignant Neoplasms;Maps;Mediating;Medical;Molecular;nanopore;novel;Nucleosomes;overexpression;Patients;Positioning Attribute;Post-Translational Protein Processing;prevent;Process;protein complex;Proteins;Recycling;Resolution;single molecule;Site;Specific qualifier value;telomere;tumor;Variant;Vision

PROJECT_TITLE: Mechanisms of epigenetic assembly, maintenance and propagation of human centromeres

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Continued opioid abuse and HIV infection contribute to exacerbated systemic and CNS inflammation. The proposed project aims to define molecular mechanisms of opiate and HIV-induced microglia activation and neuronal damage utilizing 3D spheroid cultures utilizing iPSC-derived primary human neuronal cells. These in vitro model systems will be leveraged to identify host pathways to prevent microgliosis and the resulting neuroinflammation, which are critical to preventing the neuropathogenesis of HIV.

PI_NAMEs: CHENG, CHRISTINE ;GUMMULURU, SURYARAM  (contact);MOSTOSLAVSKY, GUSTAVO

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;antiretroviral therapy;Astrocytes;Autologous;Autopsy;Binding;Biological Models;Brain;Cardiovascular Diseases;CCL2 gene;Cell Communication;Cell Culture Techniques;cell injury;Cell Line;Cell Nucleus;cell type;Cells;Cellular Metabolic Process;Chronic;chronic inflammatory disease;Clustered Regularly Interspaced Short Palindromic Repeats;comorbidity;CXCL10 gene;CXCR3 gene;cytokine;Development;experience;Exposure to;Functional disorder;Future;Genetic Transcription;Gliosis;HIV;HIV anti-retroviral;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Human;Immune;immune activation;Immune System Diseases;in vitro Model;in vivo;Incidence;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Infection;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;injection drug use;Innate Immune Response;innate immune sensing;Interferons;Interruption;Intervention;Introns;Knock-out;Link;Macrophage;Malignant Neoplasms;Microglia;mitochondrial dysfunction;Molecular;monocyte;Morphine;Myeloid Cells;Nerve Degeneration;Neurocognitive;Neuroglia;neuroinflammation;Neurologic Dysfunctions;Neuronal Injury;Neurons;Neuropathogenesis;neurotoxicity;Nuclear Export;Opiate Addiction;Opioid;opioid abuse;opioid exposure;Opioid Receptor;opioid use;opioid use disorder;Organoids;Osteoporosis;overdose death;pathogen;Pathway interactions;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Population;Predisposition;prevent;Production;Productivity;Publishing;response;Risk;RNA;Signal Transduction;single-cell RNA sequencing;socioeconomics;spheroids;substance use;Surveys;synergism;Testing;therapeutic development;Tissues;Toxic effect;transcriptomics;Viral;viral DNA;Viral Proteins;Viremia;Virus;Virus Diseases

PROJECT_TITLE: Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV Infection


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Building upon a rich, interdisciplinary research environment with numerous NIA-funded investigators, this training grant seeks to support predoctoral trainees in the Brown University School of Public Health with a focus on aging health and health services for dementia care. The objective of this training program is to meet the growing demand for investigators conducting research on the biological, psychological and social forces that shape the manner in which older Americans, particularly older adults living with dementia, utilize health services and how those services affect their health and well-being.

PI_NAMEs: JUTKOWITZ, ERIC ;MOR, VINCENT  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Aging;Alzheimer's disease related dementia;Health;Health Services;Training

PROJECT_TITLE: TRAINing in Aging Health & Health Services for Alzheimer's Disease and Related Dementias (TRAIN-ADRD)


ADMINISTERING_IC: MH

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Serious Mental Illness

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Narrative This project will establish a preliminary evidence base regarding the feasibility and acceptance of using privacy- preserving financial activity data as an objective behavioral marker in BD. Specifically, the project will: i) identify and address relevant privacy concerns; ii) develop a cross-platform prototype to collect financial activity and symptom data; and iii) develop and evaluate privacy-preserving machine learning models to detect early-warning signs in BD from financial activity data. Given the strong association between BD and financial instability, this project will provide crucial insights regarding potential assessment and intervention methods to support financial stability and overall wellbeing in BD, including for those living in remote and rural areas.

PI_NAMEs: ABDULLAH, SAEED  (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Affective;application programming interface;Behavior;Behavior Disorders;Behavioral;Bipolar Disorder;Caring;Categories;computer framework;Data;Decision Making;Devices;Early Diagnosis;Early identification;eHealth;Ensure;evidence base;expectation;federated learning;Financial Activity;financial decision making;Financial Support;Focus Groups;Goals;Group Interviews;hypomania;Impaired cognition;improved;Impulsivity;In Situ;Individual;insight;Intervention;Knowledge;Label;machine learning model;Measurement;Mental disorders;Methods;Mind;Modeling;Outcome;Participant;Pattern;payment;Personal Satisfaction;personalized intervention;Pilot Projects;Population;preemptive intervention;preventive intervention;Privacy;privacy preservation;prototype;Quality of life;Randomized, Controlled Trials;Recording of previous events;Reporting;Research;research vision;Risk Taking;rural area;Self Assessment;Stable Populations;Surveys;Symptoms;System;Time;tool;Training;trend;usability;Vision;Vulnerable Populations;Work

PROJECT_TITLE: Financial Activity Data as an Objective Behavioral Marker in Bipolar Disorder: A Feasibility and Acceptance Study

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative This study will investigate the association between sedentary behaviors (SB), brain health, and the risk of developing Alzheimer’s disease and all-cause dementia. Using a comprehensive set of both objective and self- report measures of SB from the UK Biobank, this study will form an essential foundation for developing effective behavioral interventions and prevention therapies for those at increased risk for developing Alzheimer’s disease.

PI_NAMEs: ALEXANDER, GENE E;KLIMENTIDIS, YANN CHARLES;RAICHLEN, DAVID  (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Accelerometer;Address;Adult;Aging;aging brain;Algorithms;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;Atherosclerosis;Atrophic;Attention;Attenuated;Behavior;behavior prediction;Behavior Therapy;biobank;Brain;brain based;brain health;cerebral atrophy;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive testing;cohort;Communities;Computerized Medical Record;Computers;Data;Data Set;Dementia;Dose;effective intervention;effective therapy;electronic data;executive function;Exercise;follow-up;Foundations;Framingham Heart Study;Genetic;Health;Hippocampus;human old age (65+);Impaired cognition;improved;Incidence;Individual;Intervention;Length;Life Style;lifestyle intervention;machine learning algorithm;Measurement;Measures;Memory;Methods;middle age;Modeling;Morbidity - disease rate;mortality;Multi-Ethnic Study of Atherosclerosis;Neurodegenerative Disorders;neuroimaging;novel;older adult;Outcome;Participant;Pathway Analysis;Patient Self-Report;Pattern;Physical activity;Physiological;Prevention therapy;prospective;Prospective cohort;Psyche structure;Recommendation;response;Risk;Sampling;Scanning;secondary analysis;sedentary;sedentary lifestyle;Structure;Testing;Therapeutic Intervention;Time;tv watching;wearable device;White Matter Hyperintensity;Work

PROJECT_TITLE: Inactivity, sedentary behavior, and the risk for Alzheimer’s disease in middle aged to older adults

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE This UAB Training Program in Rheumatic and Musculoskeletal Disease Research was highly successful over the initial funding period as demonstrated by mentoring and development of young investigators with interests centered on arthritis, lupus, gout, and related diseases of the musculoskeletal system. We seek to continue and enhance our vibrant, interdisciplinary, fundamental and translational research training for predoctoral students and postdoctoral fellows (MDs, PhDs, or MD/PhDs). The training faculty, resources, and environment provide an exceptionally strong mentoring environment to train the next generation of researchers in rheumatic and musculoskeletal disease.

PI_NAMEs: MOUNTZ, JOHN D (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Training Program in Rheumatic and Musculoskeletal Diseases Research


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Lung

PHR: Project Narrative Decreased lung function through inhaled Cadmium as an environmental pollutant, and particulate matter is known to cause small airway diseases; however, the mechanism remains unclear. Residents of an EPA proposed North Birmingham Superfund Site live close to coke ovens and coal fired power plants in Birmingham, AL; that makes it rich with cadmium rich polluted site, demonstrates the presence of citrullinated proteins, and decreased efferocytosis. This project will investigate how cadmium toxicity is responsible for persistent inflammation and airway remodeling.

PI_NAMEs: SUROLIA, RANU  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: 3-Dimensional;Affect;Airway Disease;airway remodeling;Area;Arginine deiminase;Biological;burden of illness;Cadmium;Calmodulin;CD36 gene;Chronic Disease;chronic respiratory disease;citrullinated protein;coal-fired power plant;Coke;Communities;Data;Disease;Environmental Exposure;Environmental Pollutants;Enzymes;Exposure to;gain of function;Hazardous Chemicals;Health;Homeostasis;Human;Impairment;improved;In Vitro;in vivo;Incidence;Inflammation;Inhalation;Interleukin-10;Knock-out;Laboratories;Life;loss of function;Lung;Macrophage;Mediating;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;Modeling;Molecular;Mus;NF-kappa B;Organoids;overexpression;Particulate Matter;Pathway interactions;Phosphotransferases;Plants;pollutant;Pollution;Population;Proteins;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Reporting;Research;Resolution;Saline;Sampling;Signal Transduction;Site;small airways disease;Steel;Structure of parenchyma of lung;Superfund;superfund site;System;Testing;Tissues;Toxic effect;Work

PROJECT_TITLE: Environmental Cadmium, persistent inflammation and airways disease

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Microbiome;Nutrition;Obesity;Pediatric;Prevention

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: We propose to examine whether a ketogenic compared to a standard diet in children with newly diagnosed diabetes would extend the honeymoon period – a transient improvement in insulin production that occurs shortly after diagnosis and greatly improves diabetes control and disease burden. Despite major pharmacological and technological advances, diabetes control remains poor in most children with diabetes, while conversely tighter diabetes control has been associated with weight gain, placing millions at risk for complications. A ketogenic diet could have benefits on insulin production, diabetes control and body weight, would be directly translatable, inexpensive and relatively free of major side-effects.

PI_NAMEs: LENNERZ, BELINDA S (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Adult;Adverse effects;aged;American;Appearance;Area Under Curve;arm;Autoimmunity;Bacteroides;Beta Cell;beta-Hydroxybutyrate;Bifidobacterium;Biological Markers;Blood Circulation;Blood Glucose;blood glucose regulation;Bluetooth;Body mass index;Body Weight;burden of illness;C-Peptide;C-reactive protein;Carbohydrates;Case Study;Cell Physiology;Child;Childhood diabetes;Clinical;Clinical Trials;cloud based;Complication;Consumption;Continuous Glucose Monitor;Data Collection;diabetes control;diabetes education;Diabetes Mellitus;Diagnosis;Diet;Dietary Carbohydrates;Dietary Intervention;Disease;Disease remission;Dose;experience;Family;Fasting;Fatty acid glycerol esters;Food;Glucose;glucose disposal;glycemic control;Glycemic Index;Glycosylated hemoglobin A;gut microbes;gut microbiome;Health;High Density Lipoprotein Cholesterol;IL17 gene;Immune;Immunologic Markers;improved;indexing;Inflammasome;Inflammation;Inflammatory;inflammatory marker;Insulin;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Interferon Type II;Interleukin-1 beta;Interleukin-10;interleukin-23;Interleukin-6;Interphase Cell;Intervention;ketogenic diet;ketogentic;Knowledge;Link;Metabolic;Metabolic Marker;Metabolic syndrome;metabolome;Microbe;microbial;microbial composition;mortality;multidisciplinary;multiple omics;Newly Diagnosed;nutrition;nutrition education;obesogenic;Outcome;Partial Remission;Pathway interactions;Patients;Peripheral;pharmacologic;Pharmacological Treatment;Physiological;Physiology;primary endpoint;Production;Randomized, Controlled Trials;Recommendation;Research;Residual state;response biomarker;Risk;Safety;secondary endpoint;Selection Bias;side effect;targeted biomarker;Technology;Testing;Therapeutic;Time;Tissues;TNF gene;Triglycerides;uptake;Variant;Weight Gain

PROJECT_TITLE: Effect of Dietary Carbohydrate on Diabetes Control and Beta Cell Function in Children with Newly Diagnosed Diabetes.”

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Cardiovascular;Data Science;Heart Disease;Hypertension;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: Newark

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative The integration of longitudinal cohort studies such as those funded by the National Heart, Lung, and Blood Insti- tute (NHLBI) has provided cardiovascular researchers an important opportunity to address emerging questions that would not have been answered by a single cohort, but at the same time substantially increases the complex- ity of data structures and demands novel analysis approaches. We develop a suite of novel Bayesian machine learning methods to address challenges posed by complex longitudinal data with censored survival outcomes, including missing exposure data, causal inference with time-varying confounding and sequential unmeasured confounding. Our work is uniquely relevant to the mission of NHLBI and is aligned within the institute's strate- gic vision, and will provide a key apparatus for advancing the understanding of emerging cardiovascular health questions via enhanced use of integrated data.

PI_NAMEs: HU, LIANGYUAN  (contact)

PROGRAM_OFFICER_NAME: WOLZ, MICHAEL

PROJECT_TERMS: Address;Adult;Age;Anti-Hypertensive Agents;Assessment tool;Atherosclerosis Risk in Communities;Bayesian Analysis;Bayesian learning;Bayesian Method;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Cholesterol;Clinical;cohort;Cohort Studies;Complex;Computer software;Data;data complexity;data integration;Data Pooling;Estimation Techniques;ethnic diversity;flexibility;follow-up;Frail Elderly;Funding;Goals;health data;Health Policy;improved;innovation;Intervention;Investigation;Knowledge;late life;Life Cycle Stages;Longitudinal cohort study;Machine Learning;machine learning framework;machine learning method;Methodology;Methods;Mission;Modeling;Multi-Ethnic Study of Atherosclerosis;National Heart, Lung, and Blood Institute;novel;older adult;Outcome;Paper;Pathway interactions;Pattern;Population;population based;Predisposition;Prevention strategy;Property;Public Health;Race;Research;Research Personnel;Risk Estimate;Risk Factors;Sample Size;Selection Bias;software development;Software Tools;Source;Specific qualifier value;Standardization;Statistical Methods;Strategic vision;Structure;survival outcome;temporal measurement;Time;Time Study;treatment effect;Trees;Uncertainty;United States National Institutes of Health;usability;Weight;Work;young adult

PROJECT_TITLE: Bayesian machine learning for causal inference with incomplete longitudinal covariates and censored survival outcomes

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Aging

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Relevance to Public Health The increasing life span is leading to greater numbers of older persons in the population. This training program is designed to prepare outstanding scientists to pursue topics that are relevant for understanding the health and functional status of an aging population, preventing the functional declines and disabilities that often accompany becoming older, and maximizing function in those with existing disabilities and disabling conditions.

PI_NAMEs: GRUBER-BALDINI, ANN L;ORWIG, DENISE L (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Aging;Epidemiology;Research Training

PROJECT_TITLE: Research Training in the Epidemiology of Aging


ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE This postdoctoral training Program will prepare scientists from a range of disciplines for independent careers in research that aims to understand the mechanisms of aging and age-related disease. We will train the next generation of scientists and provide them with the broad knowledge, interdisciplinary skills and scientific interactions they will need to alleviate, through research, the enormous human and financial burdens caused by aging and age-related diseases.

PI_NAMEs: ELLERBY, LISA M (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: age-related disease;aging related;Basic Science;Training

PROJECT_TITLE: Training in Basic Research on Aging and Age-Related Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: HERSHEY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE Olfactory deficits are prevalent in the preclinical and early stages of Alzheimer’s disease (AD) and are predictive of the conversion form mild cognitive impairment (MCI) to AD dementia. Experiments described in this proposal are designed to answer two fundamental questions regarding AD-related neurodegeneration: 1) Are olfactory deficits a direct consequence of neurodegeneration in the olfactory network, and its connectivity to hippocampus and the default mode network? and 2) If so, what are the mechanistic relationships behind early olfactory deficits, which precede memory, as well as other cognitive impairments in AD?

PI_NAMEs: KARUNANAYAKA, PRASANNA RASIKA (contact);YANG, QING X

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Affect;Age;age related;age related changes;Aging;aging related;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;amnestic mild cognitive impairment;Amyloid;Area;Behavioral;biomarker evaluation;Brain;Brain region;clinical practice;Cognition;Cognitive;cognitive function;Data;Dementia;design;Detection;Development;diagnostic tool;Discrimination;Disease;Disease Marker;Disease Progression;entorhinal cortex;experimental study;Foundations;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Goals;Hippocampus;imaging biomarker;Impaired cognition;Impairment;improved;in vivo;Inferior;Insula of Reil;Joints;Knowledge;Lead;Link;Literature;Lobe;Magnetic Resonance Imaging;Medial;medial temporal lobe;Memory;Memory impairment;memory process;mild cognitive impairment;Modeling;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;network dysfunction;neuropathology;normal aging;odor discrimination;Odors;Olfactory Cortex;Olfactory dysfunction;Outcomes Research;Parkinson Disease;Participant;Pathology;Pathway interactions;Pattern;Performance;piriform cortex;Positron-Emission Tomography;potential biomarker;pre-clinical;predictive marker;predictive modeling;Prevention;Process;prodromal Alzheimer's disease;progressive neurodegeneration;Research;Rest;risk prediction;screening;Signal Transduction;Smell Perception;Specific qualifier value;structural imaging;Structure;Temporal Lobe;Testing;Visual

PROJECT_TITLE: Linking olfactory deficits to memory impairment and AD neurodegeneration

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative In this program, we propose to determine the correlates of protection in individuals that spontaneously clear multiple HCV infection episodes. This will give highly valuable information for the design of next generation of vaccines based on emulating successful resolution of natural re-exposure and re-infection in human patients.

PI_NAMEs: GRAKOUI, ARASH  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acceleration;Acute Hepatitis C;Adolescent and Young Adult;Adoption;Anti-viral Agents;Anti-viral Therapy;Antibody Response;Antigens;B-Lymphocytes;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Chronic Hepatitis C;chronic infection;cohort;cytotoxic CD8 T cells;design;Direct Costs;DNA;Egypt;Engineering;Exposure to;Frequencies;Generations;Goals;Government;Hepatitis C;Hepatitis C virus;High Prevalence;high risk population;Human;human subject;Immune response;Immunity;Individual;Infection;Injecting drug user;Knowledge;Liver;Longevity;Memory;memory CD4 T lymphocyte;Methods;Modality;Modeling;Modified Vaccinia Virus Ankara;Monitor;neutralizing antibody;new epidemic;nonhuman primate;novel vaccines;Outcome;Participant;Patients;Persons;Pharmaceutical Preparations;Phenotype;prevent;Prevention;Primary Infection;Production;programs;Proteins;Public Health;recruit;Regimen;Research Personnel;Resolution;Resources;response;Risk;Risk Reduction;Role;Sampling;screening;Signal Pathway;Signaling Molecule;stem;success;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Time;transcription factor;vaccination strategy;Vaccine Design;vaccine development;vaccine trial;Vaccines;Viral;Viral Proteins;Virus

PROJECT_TITLE: Correlates of protective immunity to HCV and rational vaccine design


NIH_SPENDING_CATS: Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Vaccine Related

PHR: Narrative This Administrative Core will provide the coordination necessary to make effective and efficient use of resources and intermediate results from this collaborative effort. The primary function will be to facilitate scientific interactions between the Project leaders as well as Core leaders and to ensure milestones are met.

PROJECT_TERMS: Address;Annual Reports;antigen-specific T cells;B-Lymphocytes;Biometry;Budgets;Clinical;Collaborations;Communities;Complex;Consultations;data management;data sharing;Databases;Dedications;design;Development;Ensure;Goals;graduate student;Hepatitis C;Hepatitis C virus;Human;Immune response;Immunity;Individual;Infection;Infrastructure;Institution;Intellectual Property;Leadership;meetings;Methodology;Modification;nonhuman primate;novel vaccines;Outcome;Patients;Postdoctoral Fellow;Productivity;programs;Publications;Publishing;Research;Research Personnel;Research Project Grants;Resolution;Resource Allocation;Resources;response;Role;Scientist;Services;symposium;Technology Transfer;United States National Institutes of Health;Universities;vaccination strategy;Vaccine Design;Work

PROJECT_TITLE: Correlates of protective immunity to HCV and rational vaccine design: Admin Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Social Determinants of Health;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: CHARLES R. DREW UNIVERSITY OF MED & SCI

PHR: Narrative Although substance use disorders are a health disparity that occurs more commonly in minority and low-income populations, underrepresented minority researchers and researchers from disadvantaged backgrounds are less like to go into research in this field and less likely to receive funding from NIDA. The Summer Substance Abuse Disorders Research Training (SummerSART) at Charles R. Drew University (CDU) and UCLA builds on the highly successful SART grant that, in turn, built on 15 years of DIDARP/MIDARP program (PI: Friedman) in which 159 mostly minority students received a meaningful research experience in substance use disorder fields along with training and mentorship. This grant proposes to provide research opportunities and courses for skill development and mentorship to undergraduates over the summer with the goal of training the next generation of substance use disorder researchers.

PI_NAMEs: FRIEDMAN, THEODORE C (contact)

PROGRAM_OFFICER_NAME: FRIEND, LINDSEY NICOLE

PROJECT_TERMS: addiction;Area;Basic Science;biobehavior;Cancer Education Grant Program;career;Clinical;Clinical Research;community engagement;Country;design;Disadvantaged;disadvantaged background;Disease;Doctor of Philosophy;Electronic cigarette;Epidemiology;experience;faculty community;faculty mentor;Funding;Future;Goals;Grant;health disparity;Hour;Individual;Infrastructure;innovation;interest;Journals;Laboratories;Low Income Population;medical specialties;meetings;Mentors;Mentorship;Minority;minority investigator;minority student;minority trainee;minority undergraduate;multidisciplinary;National Institute of Drug Abuse;next generation;programs;Research;Research Institute;Research Personnel;Research Project Grants;Research Training;Resources;responsible research conduct;Science;Series;skill acquisition;skills;smoking cessation;Stress;Students;Substance abuse problem;substance use;Substance Use Disorder;summer student;Training;Training Programs;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;webinar

PROJECT_TITLE: Summer Substance Abuse Research Training (SummerSART)


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

PHR: Narrative The objective of this clinical core is to establish a biobank of samples from two unique cohorts: one North American cohort of people who inject drugs who cleared one hepatitis C infection and experience reinfection, and one cohort of chronically infected subjects from Egypt undergoing antiviral treatment against hepatitis C.

PI_NAMEs: SHOUKRY, NAGLAA H. (contact)

PROJECT_TERMS: Acute;American;Anti-viral Agents;Anti-viral Therapy;biobank;Blood;Blood specimen;Cells;Chronic;chronic infection;chronic liver disease;Clinical;Clinical Data;Clinical Trials;cohort;Collaborations;Country;Cytoprotection;Databases;Developing Countries;Development;Diagnosis;Disease Progression;Egypt;experience;experimental study;Exposure to;follow-up;Future;Genotype;Goals;healthy volunteer;Hepatitis C;Hepatitis C Prevalence;Hepatitis C Vaccine;Hepatitis C virus;High Prevalence;high risk;high risk population;Human Resources;Immune;Immune response;Immunity;immunogenic;immunogenicity;Immunologic Factors;Income;Individual;Infection;infection risk;Injecting drug user;injection drug use;Injections;International;Knowledge;Laboratories;Life;Liver;Liver diseases;Measures;Mediating;Medical;Modeling;North America;novel vaccines;opioid epidemic;Patients;Persons;Phase;phase II trial;Populations at Risk;Pre-Clinical Model;prevent;Procedures;Process;Public Health;public health priorities;reconstitution;recruit;Research;Research Personnel;response;Rest;Risk;Sampling;screening;seropositive;Source;Specimen;success;T-Lymphocyte;Time;Training;transmission process;vaccine candidate;Vaccine Design;vaccine evaluation;vaccine response;Vaccines;Viral;Virus

PROJECT_TITLE: Correlates of protective immunity to HCV and rational vaccine design: Clinical Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Transposons comprise approximately half of the human genome.  The piRNA pathway has a conserved  function in transposon silencing and genome maintenance during germline development, and mutations  in this pathway have recently been linked to male infertility, and insertions of these mobile  elements cause disease. This application addresses how the piRNA pathway responds to viral infection of the germline,  distinguishes between host genes and transposon, and responds to stress.  These fundamental  biological processes directly impact human health and development, and the proposed studies thus  support the mission of the NIH.

PI_NAMEs: THEURKAUF, WILLIAM EDWARD (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Address;Biogenesis;biological adaptation to stress;Biological Process;CHEK2 gene;Chromatin Disassembly;Chromatin Modeling;Chromosomal Breaks;Complex;defense response;Development;Disease;DNA Damage;driving force;Elements;Epigenetic Process;Evolution;Family;fly;Gammaretrovirus;Genes;Genetic;Genetic Variation;Genome;Genomic Instability;genomic locus;Germ Lines;Health;Heat-Shock Response;Heritability;Human;Human Genome;Immobilization;Immune system;Immunity;Invaded;Koala;Link;Maintenance;Male Infertility;Maps;Mediating;Messenger RNA;Mission;Modeling;Molecular;Mus;Mutation;Pathway interactions;Pattern;piRNA;placental mammal;Population;Process;Production;response;RNA Splicing;Role;Site;Source;Specific qualifier value;Specificity;Stress;System;Testing;Transcript;United States National Institutes of Health;Untranslated RNA;Viral Genome;Virus Diseases;Work

PROJECT_TITLE: piRNA biogenesis and function in germline development

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: Transcription factors and signaling molecules are key modulators of cartilage development, with alterations in either resulting in skeletal anomalies. We have identified a factor that is required for cartilage formation, presumably through its ability to regulate the expression of components of both of these groups. Results from this study will determine whether and how this factor controls transcription factors and signaling molecules during cartilage development, which may impact our therapeutic approach to correct skeletal defects.

PI_NAMEs: CARLONE, DIANA LYNN (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Address;Binding;Biological Assay;Birth;bone;Bone structure;Cartilage;cartilage development;cartilaginous;cell growth regulation;Cell Line;Cells;Chondrocytes;Chondrogenesis;Chromatin;chromatin immunoprecipitation;Data;data integration;Databases;Defect;density;Development;differential expression;Embryo;Epigenetic Process;epigenetic regulation;Epiphysial cartilage;Fingers;Forelimb;gene regulatory network;Genes;Genetic Markers;Genetic Transcription;genome-wide;Goals;Hindlimb;Histology;Human;In Situ Hybridization;In Vitro;insight;knock-down;Lead;Limb Bud;Link;long bone;Mediating;Mesenchymal;Mesenchymal Stem Cells;Mesenchyme;Methylation;Molecular;Mus;mutant;new therapeutic target;novel therapeutic intervention;novel therapeutics;Physical condensation;Physiologic Ossification;Process;Proteins;Quantitative Reverse Transcriptase PCR;Role;short bone;Signal Pathway;Signal Transduction;Signaling Molecule;skeletal;Skeletal Development;skeletal disorder;Skeleton;stem cell differentiation;stem cell function;stem cell survival;System;Testing;Therapeutic;transcription factor;Transcriptional Activation;Transcriptional Regulation;transcriptome;transcriptomics;treatment strategy;Western Blotting;Work

PROJECT_TITLE: Cfp1 Action in Cartilage Development

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

PHR: Narrative The main goal of this project is to characterize at high-resolution the protective signature of CD4 helper T cells during HCV reinfection in a cohort of people who inject drugs from Montreal, Canada and to examine their recovery/reconstitution following direct acting antiviral therapy in subject with chronic HCV from Egypt and Montreal.

PROJECT_TERMS: Acceleration;Aftercare;Anti-viral Agents;Anti-viral Therapy;Antibody Response;antiviral drug development;B-Lymphocytes;Benchmarking;Biological Assay;Blood;Canada;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Chemicals;Chronic;Chronic Hepatitis C;Chronic Phase;Clinical Trials;Coculture Techniques;cohort;Country;cytokine;Cytoprotection;Defect;Developing Countries;Development;Egypt;enzyme linked immunospot assay;Exhibits;Exposure to;Flow Cytometry;Genomics;Goals;Hepatitis C;Hepatitis C Prevalence;Hepatitis C virus;High Prevalence;Immune;immune function;Immune response;Immunity;immunogenicity;Immunologic Factors;Individual;Infection;Injecting drug user;Interferon Type II;Kinetics;Knowledge;Leukocytes;Liver;Liver diseases;Maintenance;marginalized population;Measures;Mediating;Mediator;memory CD4 T lymphocyte;Modeling;Molecular Profiling;neutralizing antibody;North America;novel vaccines;opioid epidemic;Pan Genus;pandemic disease;Pathway interactions;Patients;Phase;Phenotype;Predisposition;Production;protective pathway;Public Health;public health priorities;Quantitative Reverse Transcriptase PCR;reconstitution;Recovery;Resolution;response;Risk;RNA;Role;Sampling;single-cell RNA sequencing;Sorting;Source;Stains;T cell response;T memory cell;T-Cell Proliferation;T-cell receptor repertoire;T-Lymphocyte;Target Populations;Technology;Time;transmission process;Vaccination;vaccine candidate;Vaccine Design;Vaccines;Viral;Virus

PROJECT_TITLE: Correlates of protective immunity to HCV and rational vaccine design: Project 1


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative The proposed research is relevant to public health because understanding natural selection plays a key role in combating genetic and infectious diseases. The proposed research will generate new methods for identifying both negative and positive natural selection in natural populations, including humans. These methods will form a foundation for predicting, for example, rates of adaptation of pathogens and the architecture of human genetic disease.

PI_NAMEs: GUTENKUNST, RYAN  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: Population genomic inferences of history and selection across populations and time

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Nutrition;Obesity;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE  Efficacy of current immunotherapies in breast cancer is modest. Furthermore, how tissue-specific antitumor immunity is regulated in breast cancer remains unclear. By combining mouse genetics, clinical samples, and cutting-edge technologies, this project will explore a previously unappreciated mechanism by which tumor cells influence antitumor immunity and clinical response to immunotherapy.

PI_NAMEs: LI, RONG  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Adoptive Transfer;anti-tumor immune response;Attenuated;attenuation;Binding;Biological Assay;Breast Cancer Model;Breast Cancer Patient;Cancer Biology;cancer immunotherapy;Cell Compartmentation;Cell Physiology;cell type;Cells;Clinical;Clinical Oncology;Coculture Techniques;Collagen;Collagen Fibril;Collagen Receptors;Communication;comorbidity;Complex;cytokine;Data;Development;diet-induced obesity;discoidin domain receptor 1;experimental study;Extracellular Domain;Future;Human;Immune;Immunocompetent;immunodeficiency;Immunologics;Immunooncology;Immunophenotyping;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;In complete remission;In Vitro;Infiltration;Integration Host Factors;Knock-out;Knockout Mice;Knowledge;Ligands;Literature;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;migration;Molecular;mouse genetics;mouse model;multidisciplinary;Mus;neoplastic cell;New Agents;Non obese;novel;obese patients;Obesity;Obesity associated cancer;patient subsets;Patient-Focused Outcomes;Patients;Phosphotransferases;Positioning Attribute;Production;Proliferating;Protein Tyrosine Kinase;Receptor Protein-Tyrosine Kinases;Reporting;Resistance;response;Role;Sampling;Signal Transduction;Stromal Neoplasm;targeted treatment;Technology;Testing;Time;Tissues;tool;tumor;tumor growth;Tumor Immunity;tumor immunology;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-infiltrating immune cells;Woman

PROJECT_TITLE: Boosting Antitumor Immunity by Blocking Both Tumor and Adipose DDR1

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Substance Misuse

ORG_DEPT: PATHOLOGY

PHR: Narrative In ERASE HIV we have assembled a team of world leaders in HIV virology, immunology, advocacy, in vivo animal models, and drug development with the goal to define: (i) the key mechanisms regulating CD8+ T-cell- mediated antiviral functions, including cytotoxic T lymphocyte (CTL) activity and the recently described transcriptional silencing (i.e., pro-latency) effect, and (ii) the best way to manipulate these mechanisms by in vivo immune-based strategies to trigger the most effective CD8+ T-cells, NK cells, and ADCC responses to de- stabilize HIV persistence. This collaborative effort is uniquely poised to address the critical questions outlined in the proposal and to inform novel therapeutic strategies that can be translated in clinical trials to achieve viral remission and/or eradication in people living with HIV.

PI_NAMEs: KULPA, DEANNA A;PAIARDINI, MIRKO  (contact);SILVESTRI, GUIDO

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Address;Advocacy;Aftercare;Animal Model;animal model development;Animals;Antibodies;antibody-dependent cell cytotoxicity;antiretroviral therapy;Apoptosis;Basic Science;BCL2 gene;Binding;Biological Assay;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Cellular biology;Clinical;Clinical Trials;collaboratory;Communities;community involvement;Coupled;cytotoxic;Cytotoxic T-Lymphocytes;Data;Disease remission;drug development;Event;Excision;Gene Silencing;Genetic Transcription;global health;Goals;HIV;HIV Infections;Human;Immune;Immune response;Immunologics;Immunology;improved;in vivo;Infection;inhibitor;innovation;Intercept;Interleukin-10;Interleukin-15;Interruption;Intervention;Macaca mulatta;Maintenance;mathematical model;Mediating;mimetics;Modeling;Molecular;mouse model;Natural Killer Cells;novel;novel strategies;novel therapeutic intervention;Outcome;Persons;pre-clinical;preclinical study;prevent;Recrudescences;Research;response;simian human immunodeficiency virus;Specimen;synergism;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Translating;Uncertainty;Universities;Viral;Viral Physiology;viral rebound;Viral reservoir;Viremia;virology;Virus;Virus Replication;Work

PROJECT_TITLE: Enterprise for Research and Advocacy to Stop and Eradicate HIV (ERASE-HIV)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Natural Products;Nutrition;Pediatric;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Rapid, easy, and valid biomarkers of carotenoid, fruit, and vegetable intake are needed to monitor the association between infants and toddlers’ dietary intakes and health outcomes. The purpose of this project is to determine if a rapid, non-invasive measure of skin carotenoids can provide a valid estimate of carotenoid and fruit and vegetable intake in diverse American infants and toddlers, and if children’s carotenoid intake is associated with their visual function. Simple and valid measures to estimate infant and toddler fruit, vegetable and carotenoid intake will promote our understanding of children’s nutrition and health, and will help organizations to monitor children’s dietary intakes as needed to promote healthier dietary patterns.

PI_NAMEs: MORAN, NANCY E (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: absorption;Adult;Age;Agreement;alpha-carotene;American;Area;Assessment tool;Back;Beta Carotene;Biological;Biological Markers;Biological Models;Biomarker of Dietary Intake;biomarker validation;Blood;Body Composition;Body mass index;cancer risk;cardiovascular health;Cardiovascular system;Carotene;Carotenoids;Child;Child Nutrition;Child Support;Childhood;Cognitive;cognitive function;Complementary Feeding;Consumption;Contrast Sensitivity;Darkness;Data;Devices;Diet;dietary;Dietary Carotenoid;Dietary intake;Dietary Intervention;Dietary Practices;early detection biomarkers;early-life nutrition;Eating;Environment;Eye;Fatty acid glycerol esters;Food;foodborne;Foundations;Fruit;fruits and vegetables;Future;Growth;Health;Health Benefit;improved;infancy;Infant;Inflammation;Intake;Intervention;Knowledge;Life;life span;Light;Lutein;macula;Malignant Neoplasms;Measurement;Measures;Mediator;Melanins;Milk;Minerals;Monitor;nutrition;Nutritional Requirements;Oranges;Outcome;Participant;Pigments;Placebos;Plasma;Population;portability;prospective;Proxy;Randomized;Reporting;Research;Research Personnel;residence;response;Risk;Role;sex;Skin;Solid;Source;Spectrum Analysis;standard measure;Techniques;Technology;Testing;Time;Tissues;Toddler;tool;Validation;Vegetables;Venous blood sampling;Vision;Visit;Visual;Vitamin A;Vitamins;zeaxanthin

PROJECT_TITLE: Validation of biomarkers of infant and toddler carotenoid intake

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

PHR: Narrative In this Project, we propose to determine the correlates of protection in individuals that spontaneously clear multiple hepatitis C virus infection episodes. Understanding the immune responses in these individuals will provide us with valuable information to develop an effective vaccine strategy that would emulate the successful responses generated during a natural challenge with hepatitis C virus infection.

PROJECT_TERMS: Acceleration;Adoption;Affinity;Anti-viral Agents;Anti-viral Therapy;Antibodies;Antibody Response;Antigens;Attenuated;Autologous;B cell differentiation;B cell repertoire;B-Lymphocyte Subsets;B-Lymphocytes;Biological Assay;Canada;CD4 Positive T Lymphocytes;Cell Separation;chronic infection;Clinical;cohort;Contracts;Data;Drug usage;Egypt;Epitopes;Escape Mutant;Exhibits;experience;Flow Cytometry;Gene Expression Profile;Genetic Transcription;Glycoproteins;Helper-Inducer T-Lymphocyte;Hepatitis C;Hepatitis C virus;Immune;Immune response;Immunity;Immunoglobulin-Secreting Cells;Individual;Infection;Infection prevention;Injecting drug user;longitudinal analysis;Mediating;Memory B-Lymphocyte;Monoclonal Antibodies;Mutation;neutralizing antibody;new epidemic;Outcome;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Plasma Cells;polyclonal antibody;Population;Predisposition;prevent;Primary Infection;programs;Proliferating;Public Health;recruit;Resolution;response;Sampling;secondary infection;Secondary to;single-cell RNA sequencing;stem;T memory cell;transcriptome sequencing;Vaccination;Vaccine Design;vaccine strategy;Vaccines;Viral;Viral Antigens;Viremia;Virus Diseases

PROJECT_TITLE: Correlates of protective immunity to HCV and rational vaccine design: Project 2


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will address a gap in knowledge regarding how the structural organization of synapses is robustly established during development yet flexibly modified during learning to sustain behaviors. Synapses, which are specialized junctions between excitable cells, govern information flow through neural circuits, and where/how they form affects neural circuit architecture, information processing and animal behaviors. Because these mechanisms are conserved throughout evolution, the findings emerging from the completion of the proposed work will result in broad conceptual insights that will inform our understanding of how these processes could go awry in disease, including neurodegeneration and neurodevelopmental disorders.

PI_NAMEs: COLON-RAMOS, DANIEL A (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Address;Affect;Animal Behavior;Animals;Architecture;aspirate;Behavior;Biological;Brain;Caenorhabditis elegans;Cells;Cellular biology;Collaborations;Complex;Development;Disease;Event;Evolution;flexibility;in vivo;Individual;information processing;innovation;insight;Knowledge;knowledge integration;learned behavior;Learning;Memory;Metabolic;Molecular;Nerve;Nerve Degeneration;Nervous System;neural circuit;Neurodevelopmental Disorder;Neuropil;Neurosciences;novel strategies;Output;Pathway interactions;Positioning Attribute;Process;programs;Public Health;Reporting;Research;Scientist;Specificity;Structure-Activity Relationship;Synapses;Synaptic plasticity;United States National Institutes of Health;Work;working group

PROJECT_TITLE: Examination of the cell biology of the synapse and behavior


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  The mechanisms that regulate skeletal muscle topography to perfectly align muscle morphology with the overall body plan remain poorly understood. We are investigating the integrated actions of short-range navigational signals, morphogenetic gene regulatory networks, and contact-dependent cell recognition programs that direct muscle morphogenesis and regulate muscle topography. The foundational work proposed in this study will be a necessary first step toward understanding how multiple regulatory modules cooperate to direct myogenesis in more complex systems and how dysregulation of these regulatory modules contribute to human disease.

PI_NAMEs: JOHNSON, AARON N (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Actins;Anatomy;axon guidance;Biosensor;Cell Physiology;Cell Shape;Cells;Code;Collaborations;Complex;Cytoskeleton;differential expression;Disease;Drosophila genus;Embryo;Embryonic Development;Ensure;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;functional genomics;gene regulatory network;Genes;Genetic;genetic approach;Genetic Screening;Genetic Transcription;Genomics;Guanosine Triphosphate Phosphohydrolases;human disease;imaging approach;imaging study;In Vitro;in vivo;insight;Ligands;migration;Modeling;Molecular;Monomeric GTP-Binding Proteins;Morphogenesis;Morphology;Movement;Muscle;Muscle Development;Muscle Fibers;Musculoskeletal;Musculoskeletal Diseases;Mutation Analysis;Myoblasts;myogenesis;Myopathy;Pathway interactions;Pattern;plexin;polymerization;Polymers;Population Heterogeneity;programs;Protein Family;protein function;protein protein interaction;receptor;response;reverse genetics;Role;Semaphorins;Signal Transduction;single cell sequencing;Site;Skeletal Muscle;Specific qualifier value;Structural Congenital Anomalies;System;Techniques;Tendon structure;tool;transcription factor;transcriptomics;Work

PROJECT_TITLE: Cellular and Molecular Mechanisms of Myotube Guidance

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Influenza;Pneumonia and Influenza;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

PHR: PROJECT NARRATIVE This study of the largest 20th Century pandemic, the Spanish flu of 1918, aims to investigate who was at risk of dying in New York and Philadelphia, which were among the cities with the highest fatality rate. Key questions are how death rates varied across neighborhoods and over time, based on such factors as their age, racial, ethnic, and class composition, and how these neighborhood inequalities affected individual residents. The 1918 pandemic in several ways was a precursor to the COVID-19 pandemic, and the study of how inequality was affected in 1918 will provide concepts and measurement approaches that can be applied in the current case and other future pandemics.

PI_NAMEs: LOGAN, JOHN R (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: 1918 influenza pandemic;Address;Affect;Age;Area;Attention;behavior measurement;Birth Place;Cause of Death;Censuses;Cessation of life;Characteristics;Cities;Communities;Community Health;comparative;contagion;Coronavirus;Country;COVID-19;COVID-19 pandemic;Data;Data Set;Death Certificates;Death Rate;Death Records;Dimensions;Ethnic Origin;Event;experience;falls;Fatality rate;flexibility;flu;future pandemic;Gender;Genetic Transcription;Glean;Health;health disparity;Household;Individual;Inequality;Influenza;innovation;Knowledge;Link;Location;Measurement;Measures;mortality;mortality risk;multilevel analysis;Names;Neighborhoods;New York;New York City;Occupations;Outcome;outcome disparities;pandemic disease;Parents;Pattern;Persons;Philadelphia;Pneumonia;predictive modeling;previous pandemic;Public Health;Race;Records;Research;response;Risk;Risk Factors;Sampling;Severities;Social Class;social group;Societies;Spanish flu;spatial relationship;Standardization;Surveys;Survivors;System;Time;urban area;Variant

PROJECT_TITLE: Individual and Neighborhood Vulnerability to the Spanish Flu

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


PHR: Hepatitis C virus (HCV) continues to infect ~71 million people worldwide with an estimated 1.5 to 2 million new infections each year. A complete eradication of HCV infection warrants development of an effective vaccine that can rapidly induce a durable anti-viral immunity and prevent infection. The overall goal of this Project 3 is to develop an effective prophylactic vaccine against HCV.

PI_NAMEs: AMARA, RAMA RAO  (contact)

PROJECT_TERMS: Adjuvant;Antibody Response;Antigens;antiviral immunity;B-Lymphocytes;Blood;booster vaccine;CD8-Positive T-Lymphocytes;Cellular Immunity;Combined Vaccines;Comparative Study;cross reactivity;delivery vehicle;design;Development;DNA;experience;Genotype;Glycoproteins;Goals;Helper-Inducer T-Lymphocyte;Hepatitis C;Hepatitis C virus;HIV;HIV vaccine;Human;Humoral Immunities;Immune response;Immunity;Immunization;improved;In Vitro;Infection;Infection prevention;insight;Liver;Membrane;Modality;Modified Vaccinia Virus Ankara;Molecular;neutralizing antibody;nonhuman primate;Nonstructural Protein;Persons;preservation;Preventive vaccine;prospective;protein expression;Proteins;Recombinants;Regimen;Reporting;response;Role;Series;Site;Structure;T cell response;T-Lymphocyte;Testing;Tissues;TNFSF5 gene;Vaccination;vaccination strategy;Vaccine Design;vaccine trial;Vaccines;Viral;Viral Antigens;Viral Proteins;Virion;virus core;Virus Diseases;Virus Replication;Virus-like particle

PROJECT_TITLE: Correlates of protective immunity to HCV and rational vaccine design: Project 3


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infertility;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative This basic science research application is designed to increase our understanding of the cell and molecular mechanisms involved in human PGC (hPGC) specification using human pluripotent stem cells as a model. Outcomes from this project will involve acquiring the basic science knowledge necessary to understand one of the foundational events in human reproduction, the establishment of human germline cells in the embryo.

PI_NAMEs: CLARK, AMANDER  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;Basic Science;Binding;blastocyst;Cell Differentiation process;Cell Line;cell type;Cells;Child;ChIP-seq;Chromatin;CRISPR interference;Data;demethylation;design;Development;Diagnosis;DNA;DNA Methylation;egg;Embryo;embryo cell;Endoderm;Enhancers;Epigenetic Process;epigenome;Event;Failure;Fertility;Fertilization;Funding;Future;Gametogenesis;gastrulation;Gene Expression;Genome;Germ Cells;Germ Lines;Goals;Gonadal structure;Grant;Human;human embryonic stem cell;Human Genome;human induced pluripotent stem cells;human pluripotent stem cell;implantation;In Vitro;Individual;induced pluripotent stem cell;Infertility;Knowledge;Laboratories;Life;Life Cycle Stages;Long Terminal Repeats;model organism;Modeling;Molecular;Mus;mutant;natural Blastocyst Implantation;Outcome;Parents;prenatal;Process;Publishing;Reproduction;reproductive;Reproductive Health;Research;Research Proposals;Retrotransposon;Role;Scaffolding Protein;self-renewal;single-cell RNA sequencing;Site;Somatic Cell;SOX17 gene;Specific qualifier value;sperm cell;Stem Cell Research;stem cells;Structure of primordial sex cell;success;Technology;TFAP2C gene;Time;transmission process;unpublished works;Yolk Sac

PROJECT_TITLE: Cellular and Molecular Basis of Human Primordial Germ Cell Specification

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


PHR: PROJECT NARRATIVE Our training program mentors social scientists at the predoctoral and postdoctoral levels to become independent population investigators and scholars conducting responsible research to understand and improve global population health and well-being through articulating the critical contributions of the demographic, social, institutional, and environmental dimensions. The program actively recruits a diverse body of trainees to improve the representation of women, historically underrepresented groups, and other groups in the public health workforce.

PI_NAMEs: FOSTER, ANDREW D. (contact)

PROJECT_TERMS: Demography;Training

PROJECT_TITLE: Training in Demography


ADMINISTERING_IC: OD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: HIV/AIDS;Neurosciences

PHR: OVERALL – NARRATIVE This competitive renewal application seeks five years of continued support for the Yerkes National Primate Research Center of Emory University. The Yerkes Center’s mission is to conduct and support innovative biomedical and behavioral research by Core and Affiliated Scientists in order to improve the health and well- being of human and nonhuman primates.

PI_NAMEs: THADHANI, RAVI  (contact)

PROGRAM_OFFICER_NAME: BUHRING, BETTINA D

PROJECT_TERMS: animal facility;Animal Housing;animal resource;base;Basic Science;Behavioral;Behavioral Research;Biocompatible Materials;Biology;Biomedical Research;Breeding;cognitive neuroscience;Communities;data resource;Development;Discipline;Ensure;Faculty;Funding;Genetic;Goals;graduate student;Grant;Guidelines;Health;Housing;Human;Humanities;Immunology;improved;Infrastructure;innovation;International;Knowledge;Laboratories;Laboratory Research;medical specialties;member;Mental disorders;Microbiology;Mission;multidisciplinary;Nervous System Disorder;Neuropharmacology;Neurosciences;nonhuman primate;operation;Pathology;Personal Satisfaction;Postdoctoral Fellow;Primates;Process;programs;Publications;Reporting;Research;Research Infrastructure;Research Personnel;Research Training;Resources;Role;Scientist;Services;Social Behavior;Strategic Planning;training opportunity;Translational Research;undergraduate student;United States National Institutes of Health;Universities;Visit

PROJECT_TITLE: Emory National Primate Research Center


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Neurosciences;Rare Diseases;Regenerative Medicine

ORG_CITY: STANFORD

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative: Degeneration of sensory hair cells causes vestibular dysfunction. The vestibular organ utricle regenerates to a limited degree in mice, whether this occurs in humans is unclear. The proposed research aims to apply molecular and genetic tools to probe live human utricles from organ donors and vestibular schwannoma patients to reveal mechanisms of human vestibular hair cell regeneration.

PI_NAMEs: CHENG, ALAN GI-LUN (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Acceleration;Acoustic Neuroma;Address;Adult;Animal Model;Auditory;Autopsy;Award;Bioinformatics;Biological Models;Capsid;career;Cell Maturation;Cells;Chickens;Cochlea;cohort;Cryoultramicrotomy;Cytomegalovirus;Dependovirus;design;Development;differential expression;Disease;Dissociation;Dizziness;Down-Regulation;effective therapy;Equilibrium;Excision;experience;experimental study;Fetal Tissues;Functional disorder;gain of function;gene therapy;Genes;Genetic;Glial Fibrillary Acidic Protein;Goals;hair cell regeneration;Hair Cells;hair regeneration;Histologic;Human;human disease;Immunohistochemistry;In Situ;In Situ Hybridization;In Vitro;in vivo;Institution;Investigation;Knowledge;Labyrinth;Mechanoreceptor Cell;Medical;Medical Records;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);Molecular;Molecular Profiling;Mus;Natural regeneration;novel;Operative Surgical Procedures;Organ;Organ Donor;overexpression;patient oriented research;Patients;promoter;Recording of previous events;recruit;Research;Research Personnel;restoration;Sensory;Sensory Disorders;Sensory Hair;single-cell RNA sequencing;skills;stem cells;Supporting Cell;Technology;Temporal bone structure;Testing;Therapeutic;Time;Tissues;tool;Training;transcription factor;transcriptome;transduction efficiency;Translations;Tropism;Utricle structure;Vertigo;Vestibular dysfunction;Vestibular function;Vestibular Hair Cells;Vestibular inner ear;vestibular system;Zebrafish

PROJECT_TITLE: Mentoring Patient Oriented Research in sensory disorders


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Alzheimer’s disease impacts 6.5 million Americans and is projected to affect more than 12 million by 2060, if there are no significant advances in prevention and treatment. To address these needs, we must study non- neuronal, but increasingly important, drivers of Alzheimer’s, such as vascular and aging influences. This project will utilize in vitro models to understand these dysfunctions and will contribute significantly to our understanding of Alzheimer’s disease, increasing the scientific potential to design specific therapeutics to reduce illness and disability.

PI_NAMEs: CHUNG, TRACY D. (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: abeta deposition;Address;Affect;Age;age effect;age related;aged;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;American;Amyloid;Animals;Autopsy;Biological;Biological Assay;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;brain endothelial cell;brain tissue;career;Categories;Cells;Cerebral Amyloid Angiopathy;Cerebrovascular system;Circulation;combinatorial;Communication;Complex;Cues;Data;Data Set;design;Development;disability;Disease;Disease Progression;education resources;Endothelial Cells;epidemiology study;Etiology;experimental study;Exposure to;extracellular;familial Alzheimer disease;Fellowship;Functional disorder;Future;Gene Expression Profile;Gene set enrichment analysis;genetic signature;glucose transport;Goals;Hemorrhage;Human;human data;human old age (65+);Hydrogen Peroxide;Image;imaging study;Immunohistochemistry;Impaired cognition;Impairment;in vitro Model;in vivo;Individual;Induced Mutation;Institution;Intervention;Leadership;Libraries;Memory Loss;Mentorship;Microfabrication;Modeling;Molecular;Mutation;nanobiotechnology;Nerve Degeneration;Neurofibrillary Tangles;occludin;Older Population;Onset of illness;Outcome;Oxidative Stress;Pathologic;Pathology;Pathway interactions;Perfusion;Permeability;Pharmacology Study;Phenotype;Physiological;presenilin-1;Prevention;Proteomics;Publishing;Research Training;Resolution;response;Role;Senile Plaques;Serum;skills;solute;spatiotemporal;stem cell differentiation;stem cells;Structural defect;success;Symptoms;Therapeutic;Tissue Engineering;Tissues;Toxin;Training;transcriptome sequencing;transcriptomics;Transgenic Mice;Universities;Validation;Vascular Diseases

PROJECT_TITLE: The combinatorial effects of familial mutations, oxidative stress, and aging on BBB dysfunction in Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Hematology;Infectious Diseases;Lung;Rare Diseases;Sepsis

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: NARRATIVE / RELEVANCE TO PUBLIC HEALTH Acute lung Injury (ALI), a common cause of respiratory failure in critically ill patients such as those with sepsis and COVID-19, affects ~200,000 Americans each year with 10-15% of intensive care admissions and is associated with a mortality rate of ~ 25-40% in reported cases. All current therapies for ALI and its more severe form Acute Respiratory Distress Syndrome (ARDS) rely on supportive care to improve clinical outcome and no effective drugs have been developed. The proposed studies are designed to understand how BiP/GRP78 and Mortalin/GRP75, two important proteins present in endoplasmic reticulum and mitochondrion respectively, collaborate in causing ALI/ARDS and have the potential for the development of an efficacious and superior therapeutic strategy that relies on combined inhibition of BiP/GRP78 and Mortalin/GRP75 to control ALI/ARDS in sepsis.

PI_NAMEs: FAZAL, FABEHA  (contact);RAHMAN, ARSHAD

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Admission activity;Affect;Agonist;American;Blood Vessels;Case Study;cecal ligation puncture;chelation;Clinical;clinically relevant;Collaborations;Communication;Complementary DNA;COVID-19;Critical Illness;Death Rate;design;Development;Dose;effective therapy;Endoplasmic Reticulum;Endothelial Cells;Endothelium;Functional disorder;Gene Transfer;Goals;GRP75;GRP78 gene;Human;improved;In Vitro;in vivo;Inflammasome;Inflammation Mediators;Inflammatory;inhibitor;Injury;insight;Intensive Care;ITPR1 gene;Knockout Mice;Life;Link;Liposomes;Lung;lung injury;lung vascular injury;Mediating;Mediator;Membrane;Membrane Proteins;Mitochondria;mitochondrial dysfunction;Molecular Chaperones;mortalin;mortality;mouse model;Mus;novel;novel therapeutic intervention;Outcome;overexpression;Pathogenesis;Patients;Permeability;Pharmaceutical Preparations;Plasma;prevent;Preventive;Proteins;Public Health;Respiratory Failure;response;Rest;Role;Sepsis;septic;septic patients;Signal Transduction;Site;small hairpin RNA;Supportive care;Testing;Therapeutic;therapeutic target;Thrombin;uptake;vascular inflammation

PROJECT_TITLE: MAM Proteins in Lung Vascular Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-B(03)]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The proposed research is relevant to public health because chitin synthases (CHSs) are highly promising and clinically unexploited targets of antifungal therapeutics, and existing CHS inhibitors exhibit in vivo antifungal activities against pathogens that cause endemic invasive fungal infections in humans. The proposed project will provide an atomic-level understanding of the catalysis and inhibition of CHSs from pathogenic fungi. Since such knowledge is critical for the future development of clinically useful CHS-targeting antifungal antibiotics, the proposed research is an important step towards combating fungal infections.

PI_NAMEs: LEE, SEOK-YONG ;YOKOYAMA, KENICHI  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Active Sites;Adverse effects;Agriculture;Anabolism;analog;anti-fungal agents;Anti-fungal Antibiotics;Binding;Biological Assay;Candida;Candida albicans;Catalysis;Cell division;Cell Wall;Cellular Structures;Chitin;Chitin Synthase;Clinical;clinical development;clinical investigation;Coccidioidomycosis;Code;Complex;Cryoelectron Microscopy;Dependence;Development;divalent metal;Drug resistance;drug sensitivity;Emerging infection;Enzyme Inhibitor Drugs;Enzyme Interaction;Enzymes;Evaluation;Exhibits;FDA approved;Foundations;Fungal Components;fungicide;fungus;Future;Genes;Genome;glycosyltransferase;Goals;Human;Immunocompromised Host;in vivo;inhibitor;insight;Kinetics;Knock-out;Knowledge;Length;Membrane;Methods;Molecular;Molecular Conformation;Mycoses;nikkomycin;novel;Nucleosides;Organism;pathogen;pathogenic fungus;periplasm;Physiology;Polysaccharides;Predisposition;programs;Public Health;Reaction;Regulation;Research;Resistance;resistance mechanism;Resolution;Structure;Structure-Activity Relationship;synergism;Testing;Therapeutic;Toxic effect;translational potential;Travel;Variant

PROJECT_TITLE: Catalysis and inhibition of chitin synthesis from pathogenic fungi

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Genetic alterations in eggs or sperm (e.g., abnormal chromosome numbers, genome rearrangements, and other mutations) cause developmental disabilities or miscarriage. These abnormalities often arise because of defects in meiotic homologous recombination, which can also cause infertility. This project will address fundamental questions about the mechanism and control of recombination and thus is of direct relevance to human reproductive health and disease.

PI_NAMEs: KEENEY, SCOTT  (contact);PATEL, DINSHAW J

PROJECT_TERMS: Affect;Affinity;Aneuploidy;Binding;Biochemical;Biological Assay;Biological Process;Biology;biophysical analysis;biophysical techniques;Cells;Child;Child Development;chromosome number abnormality;Chromosome Pairing;Chromosome Segregation;Collaborations;Collection;Complex;Computer Models;Computing Methodologies;Cryoelectron Microscopy;Cytology;Defect;Development;Developmental Disabilities;DNA;DNA Binding;DNA Double Strand Break;DNA mapping;egg;Engraftment;Ensure;experimental study;Fertility;Gene Modified;Genetic;Genetic Materials;Genetic Recombination;Genetic Screening;Genetic study;Genome;Genomics;Germ Cells;Germ Lines;Goals;homologous recombination;Human;In Vitro;in vivo;Infertility;innovation;Joints;Location;Mammals;Meiosis;Meiotic Recombination;Methods;Modeling;Molecular;Molecular Genetics;Mouse Protein;Mus;Mutation;Nature;NMR Spectroscopy;novel strategies;Nucleoproteins;offspring;parallelization;Parents;Phenotype;Physical condensation;Physiological;Play;Process;Property;protein structure;Proteins;Publications;Recombinants;recruit;Regulation;reproductive development;Reproductive Health;reproductive success;reproductive system disorder;Resolution;Role;Saccharomyces cerevisiae;single molecule;Site-Directed Mutagenesis;sperm cell;SPO11 gene;Spo11 protein;Spontaneous abortion;stem cells;stoichiometry;Structure;Surface;Testing;Testis;Time;Topoisomerase;transmission process;Transplantation;X-Ray Crystallography;yeast genetics;Yeasts

PROJECT_TITLE: Structural and functional principles underlying germline genome transmission

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Primary Health Care;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Loneliness, which is the perceived feeling of insufficient personal relationships, is related to higher risk for inappropriate opioid use and opioid use disorders in patients who are taking opioids long-term. Our study seeks to pilot test the evidence-based loneliness interventions of psychological therapy and social navigation in patients on chronic opioids treated in primary care practices, to determine if reducing loneliness can lower opioid misuse.

PI_NAMEs: TONG, SEBASTIAN  (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: Address;Alaska;arm;Behavior;behavioral health;care seeking;Caring;Chronic;chronic pain patient;Clinic;Cognitive Therapy;COVID-19 pandemic;Data;Development;Dose;effectiveness clinical trial;efficacious intervention;Ethnic Origin;evidence base;Evidence based intervention;experience;feasibility testing;Feeling;functional status;Future;Gender;Geographic Locations;Goals;Group Meetings;Health;Health Professional;high risk;Idaho;implementation outcomes;improved;improved outcome;innovation;Intervention;Loneliness;Measures;Mediating;Montana;Opioid;opioid misuse;opioid use;opioid use disorder;Outcome;Pain;Pain interference;pain outcome;Participant;patient engagement;patient population;Patient-Focused Outcomes;Patients;Pattern;Perception;pilot test;pilot trial;poor health outcome;Population;post intervention;practice-based research network;pragmatic trial;prescription opioid;prevent;Primary Care;primary care clinician;primary care patient;primary care practice;primary care setting;primary outcome;psychologic;Quality of life;Race;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery Support;Reporting;Research;Risk;secondary outcome;Series;social;social cognition;Social Network;social skills;Social support;Substance Use Disorder;System;Testing;Therapeutic Intervention;Time;treatment as usual;Washington;Wyoming

PROJECT_TITLE: Addressing Loneliness in Primary Care Patients on Chronic Opioids to Prevent Opioid Misuse


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Cancer;Colorectal Cancer;Digestive Diseases;Liver Disease;Nanotechnology

ORG_CITY: YADKINVILLE

ORG_NAME: DEEP CREEK PHARMA, LLC

PHR: PROJECT NARRATIVE This Phase 2 STTR proposal will develop CF10, the first DNA-based fluoropyrimidine (FP) polymer, as a new treatment for metastatic colorectal cancer (mCRC). The best available treatments for mCRC use 5-fluorouracil (5-FU)-based regimens and were optimized over decades, but result in <15% 5 year survival with <50% of mCRC patients treated with chemotherapy surviving 1 year. Through Phase 1 STTR support, we demonstrated improved anti-cancer activity for CF10 in rodent colon cancer models and an improved toxicity profile relative to 5-FU. To advance CF10 into clinical trials we will test for improved survival relative to current therapy in a rodent model of pre-treated mCRC. We also develop a lipid nanoparticle (LNP) formulation to improve CF10 pharmacokinetics. Safety Pharmacology testing of CF10 with LNP formulation will be performed in rodents and non-human primates (NHPs). Our studies will provide a foundation for regulatory approval to initiate clinical studies. Ultimately, CF10, will improve long-term survival for patients with mCRC.

PI_NAMEs: GMEINER, WILLIAM H. (contact)

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: Animal Model;anticancer activity;Award;Biochemical;Biodistribution;cancer cell;Cancer Model;chemotherapy;Clinical;clinical candidate;clinical development;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;colon cancer patients;Colon Carcinoma;Colonic Neoplasms;Colorectal;Colorectal Cancer;colorectal cancer treatment;commercialization;Data;Death Rate;design;Disease;disease model;DNA;Dose;Drug Combinations;Drug Kinetics;efficacy testing;FDA approved;fluoropyrimidine;Fluorouracil;Formulation;Foundations;Generations;Genetic;Human;Immunotherapy;improved;innovation;Laboratories;Leucovorin;lipid nanoparticle;Lung;Malignant neoplasm of gastrointestinal tract;medical schools;Metabolism;metastatic colorectal;Metastatic Neoplasm to the Liver;Modeling;mouse model;Mus;nonhuman primate;novel strategies;Nucleic Acids;Outcome;oxaliplatin;Patients;Pfizer-BioNTech COVID-19 vaccine;Pharmaceutical Preparations;pharmacokinetic model;pharmacologic;Pharmacologic Substance;Pharmacology;Pharmacology and Toxicology;Pharmacology Study;Phase;phase 2 study;Physiological;Physiology;Polymers;Preclinical Drug Development;preclinical study;Preclinical Testing;Property;Rattus;Refractory;Regimen;Research;Rodent;Rodent Model;Safety;Saline;Schedule;Small Business Technology Transfer Research;standard of care;Sterility;systemic toxicity;targeted treatment;Testing;Therapeutic;therapy resistant;Toxic effect;Toxicity Tests;Toxicology;Translating;tumor

PROJECT_TITLE: Improved Treatment of Colorectal Cancer with CF10

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-T(10)B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative This is a multidisciplinary, highly collaborative consortium that combines next-generation sequencing with state-of-the-art behavioral screening in a unique, genetically diverse, nonhuman animal model. The goals of this consortium are to identify gene variants that are associated with oxycodone use, the effects of oxycodone on analgesia and pain using genome-wide association studies (GWAS), and the sensitivity to FDA-approved treatments in behaviorally characterized heterogeneous stock rats, and to maintain a data/tissue repository (Oxycodone BioBank) accessible to all researchers to study the cellular and molecular mechanisms of oxycodone addiction. Results from these studies have the potential to have a sustained and powerful impact on the field of addiction because they will identify novel druggable targets, provide a comprehensive analysis of oxycodone addiction-like behaviors in males and females, and maintain a unique data/tissue repository that will facilitate follow-up and replication studies.

PI_NAMEs: GEORGE, OLIVIER  (contact);PALMER, ABRAHAM A

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Absence of pain sensation;addiction;Analgesics;Animal Genetics;Animal Model;Animals;Behavior;Behavioral;behavioral phenotyping;biobank;Biological;Brain;Brain region;Chronic;Collaborations;Communities;comorbidity;Complex;Computer software;cost;Data;data integration;deep neural network;Development;Disease;endophenotype;Environment;Epigenetic Process;Family Study;FDA approved;Female;follow-up;Foundations;Gene Expression;Genes;Genetic;genetic analysis;genetic variant;genome sequencing;genome wide association study;genomic locus;Genomics;Genotype;Goals;Heritability;Human Genome;Hyperalgesia;improved;Individual;Infrastructure;Intake;Intravenous;Investigation;Lead;longitudinal analysis;Machine Learning;male;Maps;Methodology;Modeling;Molecular;multidisciplinary;multiple omics;National Institute of Drug Abuse;new therapeutic target;next generation;next generation sequencing;novel;novel strategies;Nucleotides;Opiate Addiction;opioid use disorder;Outcome;Oxycodone;oxycodone self-administration;Pain;Phenotype;Physiology;pre-clinical;Procedures;programs;Quantitative Trait Loci;Rattus;Research;Research Personnel;Resistance;Resources;Risk;Sample Size;Sampling;screening;screening program;Self Administration;sex;Sex Differences;Standardization;Substance abuse problem;Substance Addiction;Substance Use Disorder;Tandem Repeat Sequences;Technology;Tissue Banks;Tissues;trait;transfer learning;Twin Studies;United States National Institutes of Health;Variant;Video Recording;Withdrawal

PROJECT_TITLE: Use of Next-Gen Sequencing to Identify Genetic Variants that Influence compulsive Oxycodone Intake in Outbred Rats


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biomedical Imaging;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: OMAHA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: NARRATIVE The proposed research is significant because it will provide a critical step forward in the development of a humanized glial mouse model of NeuroAIDS that can mirror human disease. Natural progression of brain infection and disease in relation to peripheral HIV infection makes this mouse model most relevant for the studies of viral reservoir assessments, neuropathology, and therapeutic development including eradication strategies. These mice are important tools to study the role of substances of abuse on viral reservoirs and HAND.

PI_NAMEs: GORANTLA, SANTHI  (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: abuse liability;Acceleration;Acute;acute infection;Affect;Aging;animal imaging;Animal Model;Animals;antiretroviral therapy;Area;Astrocytes;axon injury;Behavior;Behavioral;Binding;Blood;Blood Cells;Blood Vessels;Brain;cell behavior;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Chimera organism;Chronic;chronic infection;Cocaine;Contracts;detection assay;Development;Disease;Disease Progression;Disease remission;Drug abuse;drug of abuse;Epidemic;Evaluation;experience;Functional disorder;genetic signature;Goals;Hematopoietic Stem Cell Transplantation;HIV;HIV Infections;HIV Seropositivity;HIV-associated neurocognitive disorder;HIV/AIDS;Homeostasis;Human;human disease;Human immunodeficiency virus test;humanized mouse;Image;imaging modality;Immune system;Immunity;immunodeficiency;Impaired cognition;Incidence;Infection;Infiltration;Inflammation;insight;Intervention;Invaded;Investigation;Kinetics;Link;Long-Term Potentiation;Macrophage;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Methods;Microglia;Modeling;mouse model;multimodality;Mus;Nervous System Disorder;neuroAIDS;neurocognitive disorder;Neuroglia;Neuronal Injury;Neurons;Neuropathogenesis;neuropathology;neurophysiology;nucleic acid detection;Opportunistic Infections;Outcome;Pathogenesis;Pathology;Peripheral;Predisposition;Prevalence;Productivity;reconstitution;Recurrence;Reporter;Research;Research Personnel;Residual state;Rodent Model;Role;serial imaging;Severities;single-cell RNA sequencing;skills;Substance abuse problem;Substance of Abuse;substance use;Substance Use Disorder;Synaptic plasticity;Therapeutic;therapeutic development;therapeutic target;Tissue-Specific Gene Expression;tool;transmission process;Viral;viral rebound;Viral reservoir;Virus;Virus Diseases;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Impact of drugs of abuse on HIV brain reservoirs and HAND in humanized microglia mice


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative Damage to our genome, including DNA double-strand breaks programmed in developing lymphocytes, must be recognized and efficiently repaired to avoid oncogenic aberrations, such as chromosomal translocations. The DNA break response includes extensive revisions of regional chromatin; however, the impact of spatial architecture surrounding damage sites on their subsequent repair remains unknown. This project will define how the three-dimensional conformation of our genome can aid or impede the holding together of broken chromosome ends until they are repaired, thus impacting their potential to produce cancer-causing alterations.

PI_NAMEs: OLTZ, EUGENE M (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 3-Dimensional;Affect;Antigen Receptors;Architecture;ataxia telangiectasia mutated protein;Binding;Binding Sites;Cell Cycle;Cells;Chromatin;Chromosomal Breaks;Chromosomal translocation;Chromosome Deletion;Chromosomes;cohesin;Complex;Coupled;Defect;defined contribution;Diffusion;Distant;DNA;DNA Damage;DNA Double Strand Break;DNA metabolism;DNA Sequence Alteration;DNA-Directed RNA Polymerase;Double Strand Break Repair;Elements;Enhancers;Environment;Epigenetic Process;Funding;G1 Arrest;G1 Phase;Gamma-H2AX;Gene Expression;gene repression;Generations;Genes;Genetic Recombination;Genetic Transcription;Genome;Genome Stability;Genomic Instability;Goals;Histones;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;Impairment;innovation;Knowledge;Lesion;Link;Location;Lymphocyte;lymphoid neoplasm;Maintenance;Malignant Neoplasms;mammalian genome;Mediating;Molecular Conformation;Nonhomologous DNA End Joining;Oncogenic;Outcome;Pattern;Phosphorylation;Physiological;Physiological Processes;Probability;Process;promoter;Receptor Gene;recruit;repaired;Repression;Resolution;response;Rest;Side;Site;Somatic Cell;spatial integration;Stretching;Structure;Surface;Testing;Topoisomerase;V(D)J Recombination;Variant

PROJECT_TITLE: TOPOLOGICAL MECHANISMS OF DNA BREAK REPAIR IN LYMPHOCYTES

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Precision Medicine

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Chronic pain is a major healthcare problem with annual cost of above $600 billion in the United States; generalizability of available evidence for treatment of chronic pain (mostly from traditional explanatory randomized controlled trial data) is problematic as these trials exclude up to 90% of patients: leaving out real- world patients with serious medical and psychological comorbidities. We will perform a pragmatic randomized comparative effectiveness trial using our point-of-care randomization. We will then use the data from this trial to build a model predicting the response to anti-convulsants and anti-depressants to develop a platform for precision health: predicting how to choose the best medication for each patient with chronic pain.

PI_NAMEs: SALMASI, VAFI  (contact)

PROGRAM_OFFICER_NAME: SYPEK, ELIZABETH IRENE

PROJECT_TERMS: Academic Training;anti-depressive agents;Anticonvulsants;Anxiety;career;career development;Characteristics;chronic pain;chronic pain management;chronic pain patient;Clinic;Clinic Visits;Clinical;clinical care;Clinical Data;clinical epidemiology;clinical pain;clinical practice;Clinical Research;clinical training;Clinical Trials;Clinical Trials Design;comorbidity;Comparative Effectiveness Research;comparative effectiveness trial;compare effectiveness;cost;Data;Data Collection;Decision Making;Decision Support Systems;Development;effective therapy;Equipoise;Exclusion;flexibility;Funding;Goals;Healthcare;Healthcare Systems;improved;individual patient;Institution;Judgment;Learning;Logistic Regressions;low socioeconomic status;Machine Learning;machine learning algorithm;Master of Science;Medical;Medicine;Mental Depression;Mentors;Mentorship;Modeling;Observational Study;open source;Pain;pain catastrophizing;Pain intensity;Pain interference;Pain management;Patient Care;patient oriented;patient subsets;Patients;personalized medicine;Pharmaceutical Preparations;Physical Function;Physicians;Pilot Projects;point of care;Pragmatic clinical trial;pragmatic trial;Precision Health;predicting response;Predictive Factor;predictive modeling;Process;psychologic;Publications;Randomized;Randomized, Controlled Trials;real world application;Reporting;Research;research and development;Resources;response;Scientist;Site;Social Functioning;Societies;statistics;Surveys;Testing;tool;Training;treatment arm;treatment response;United States;United States National Institutes of Health

PROJECT_TITLE: Integrating Pragmatic Comparative Effectiveness Research into a Tertiary Pain Management Center

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome;Rare Diseases;Scleroderma;Wound Healing and Care

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Systemic sclerosis (scleroderma) has prominent autoimmune and fibrotic features but their interplay is not well- understand. Herein, we characterize the role of Interferon Regulatory Factor 7 (IRF7) as a key link between these two components which could represent a significant step forward in understanding the molecular basis of systemic sclerosis. This additional insight into the disease mechanism can open the door for the development of more effective treatment options in this potentially devastating disease.

PI_NAMEs: ASSASSI, SHERVIN  (contact);WU, MINGHUA

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Address;Attenuated;Autoimmune;Autoimmune Diseases;Bleomycin;Blood;Blood Cells;Cell Line;ChIP-seq;conditional knockout;CRISPR/Cas technology;Data;Dermal;Development;Disease;effective therapy;Effector Cell;experimental study;Fibroblasts;Fibrosis;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Expression Regulation;Genetic Predisposition to Disease;Genetic Transcription;Goals;Human;Immune;Immune system;Immunity;In Vitro;in vivo;indium-bleomycin;insight;interferon regulatory factor-7;Interferon Type I;Interferons;knock-down;Knockout Mice;Link;Longitudinal cohort;MADH3 gene;Mediating;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Mus;Organ;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;peripheral blood;Publishing;response;Rheumatism;RNA;Role;Sampling;Scleroderma;Signal Transduction;Single Nucleotide Polymorphism;single-cell RNA sequencing;Skin;skin fibrosis;Skin Tissue;System;Systemic Scleroderma;targeted treatment;Tissues;Transcript;transcription factor;transcriptome sequencing;Transforming Growth Factor beta;Up-Regulation;Work

PROJECT_TITLE: Interferon Regulatory Factor 7 Links Interferon Pathway Activation to the Exaggerates Fibrotic Response in Systemic Sclerosis


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

PHR: PROJECT NARRATIVE To break the cycle of persistent community gun violence that primarily affects low-income, Black, and Latinx neighborhoods, this proposal aims to challenge long-standing structural racism, manifest through redlining and mass incarceration, and the social context that permits and normalizes trauma after exposure to gun violence. TRUE HAVEN: TRUsted rEsidents and Housing Assistance to decrease Violence Exposure in New Haven is a multi-level, multi-component, strengths-based, community-driven intervention focused on reducing gun violence by (1) improving housing stability through providing financial assistance coupled with comprehensive financial education and (2) fostering greater support for mental health by training a trusted network of community members in trauma-informed counseling. We will test the effectiveness of TRUE HAVEN within specified neighborhoods using a step wedge design, while also identifying intervention facilitators and barriers and project long-term outcomes using a simulation model, yielding a roadmap for how cities can effectively and systematically tackle structural racism to reduce gun violence and improve community health and well-being.

PI_NAMEs: ROY, BRITA ;SPELL, VIRGINIA T;WANG, EMILY AI-HUA (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Address;Adoption;Affect;Age Years;Barbering;black men;Black race;Businesses;Chronic;Chronic stress;Cities;Civil Rights;cognitive performance;cohesion;Communities;community academic partnership;community building;Community Health;community led intervention;Community Networks;compare effectiveness;Connecticut;Counseling;Coupled;Couples;Data Analyses;design;Development;dynamic system;Education;effectiveness testing;effectiveness/implementation study;Enrollment;ethnic minority;experience;Exposure to;Faculty;Faith leader;Family;Financial Support;Fostering;Generations;Goals;Government;gun violence;Health;Health behavior and outcomes;health training;Home;Homicide;Housing;Hybrids;implementation intervention;Imprisonment;improved;Incidence;Individual;Institution;intergenerational;Intervention;Investments;Latinx;Leadership;Life;Low income;Maintenance;marginalized community;Medicine;member;Mental Health;Mentors;Modeling;models and simulation;Neighborhoods;Outcome;Ownership;Participant;payment;Personal Satisfaction;Persons;physical conditioning;Policies;poor health outcome;population health;programs;racial minority;Research;Research Design;Resources;response;social cohesion;Social Environment;social factors;Specific qualifier value;spelling;structural determinants;Structural Racism;Structure;systemic intervention;Techniques;Testing;Training;Trauma;Trust;Universities;Victimization;Violence;violence exposure;Virginia;Well in self;Youth