ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: ORTHOPEDICS

PHR: Narrative The Achilles Tendinopathy Center of Research Translation (AT-CORT) at the University of Pennsylvania will foster fundamental discoveries to guide clinical translation, as well as develop and employ novel translational resources, models and technologies, to address the highly significant research and clinical challenge of Achilles tendinopathy. The Overall goal of the AT-CORT is to develop new insight and technologies that uncover the mechanobiologic basis of Achilles tendinopathy across length scales, from the nucleus, to the cell, to the tissue microenvironment to patients. Together, our highly interdisciplinary team, innovative tools, and interactive Research Projects and Cores will dramatically advance knowledge, develop innovative tools and insight, and provide new directions for translation of new therapies to treat Achilles tendinopathy.

PI_NAMEs: SOSLOWSKY, LOUIS J (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: achilles tendon;Address;Adjuvant;Animal Model;Animals;Ankle;Architecture;Area;Back;Basic Science;Biological;Biological Models;Biopsy;Cell Nucleus;Cells;Center for Translational Science Activities;chromatin remodeling;Clinical;Clinical Data;clinical translation;Clinical Treatment;Communication;Communities;cost;Cytoskeleton;Data;design;Development;disability;Disease;Disease Progression;effective therapy;Elements;epigenetic regulation;Etiology;foot;Fostering;Frequencies;Genome;Goals;Grant;Homeostasis;Human;human subject;human tissue;improved;innovation;insight;interest;Intervention;Knowledge;Length;Measurement;mechanical force;mechanical load;Mechanics;Modality;Modeling;Monitor;multidisciplinary;novel;novel therapeutic intervention;novel therapeutics;older patient;Onset of illness;Operative Surgical Procedures;Outcome;Pain;Pathogenesis;Patients;Pattern;Pennsylvania;Phenotype;Population;Positioning Attribute;Prevalence;Process;programs;Regimen;Regulation;Rehabilitation therapy;Research;Research Project Grants;Resources;Role;Scientist;Signal Pathway;small molecule;Societies;Source;Specimen;superresolution imaging;Surgeon;Technology;Tendinopathy;tendon development;Tendon structure;Therapeutic Intervention;Tissues;tool;Translating;Translational Research;translational scientist;Translations;Universities;Work


ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PROJECT_TERMS: Address;Advisory Committees;Animal Model;Animals;Area;Back;Beds;Biological Assay;Cell Nucleus;Cells;Center for Translational Science Activities;Clinical;Committee Membership;Communication;Communities;cost;Data;Development;disability;effective therapy;Ensure;Etiology;Evaluation;experience;Fostering;Frequencies;Funding;Future;Grant;human subject;in vivo;innovation;interest;Leadership;Modality;Modeling;Monitor;multidisciplinary;Musculoskeletal Diseases;new technology;older patient;Pain;Pathogenesis;Pennsylvania;Physiological Processes;Positioning Attribute;Prevalence;Productivity;programs;Reporting;Research;Research Activity;Research Project Grants;Resources;Role;Scientist;Series;Societies;Structure;Technology;Tendinopathy;Tendon structure;Testing;Tissues;translational impact;Translations;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

PI_NAMEs: BAXTER, JOSH  (contact)

PROJECT_TERMS: Acceleration;achilles tendon;Acute;Address;Animal Experiments;Animals;Attenuated;Biological Assay;care delivery;Caring;Cells;Center for Translational Science Activities;Chemicals;Chronic;Clinical;Clinical Research;clinical translation;Clinical Trials;clinically relevant;cost;Data Set;Disease;Disease Progression;Dose;early onset;effectiveness testing;Equity;Exercise;follow-up;fundamental research;Funding;Future;gait examination;healing;Health;Homeostasis;Hospitals;Human;human tissue;improved;in vivo;Inequity;Injections;innovation;Insurance Carriers;Intuition;Joints;Link;mechanical load;Mechanics;Medicine;metabolomics;Modeling;Monitor;Musculoskeletal;new technology;novel;Operative Surgical Procedures;Outcome;Pain;pain symptom;Pathogenesis;Patient Care;patient population;Patient-Focused Outcomes;Patients;Physical therapy;Population;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical study;Protocols documentation;Rattus;Regimen;Registries;rehabilitative care;Reporting;Research;Research Personnel;Research Project Grants;research study;Rural Community;Sampling;Science;suburban communities;Techniques;Tendinopathy;Tendon Injuries;tendon rupture;Tendon structure;Testing;Therapeutic Agents;therapeutic effectiveness;Tissues;tool;Translating;translation assay;translational impact;Translational Research;Translations;Ultrasonography;ultrasound;United States National Institutes of Health;Urban Community

PROJECT_TITLE: Research Core


PI_NAMEs: DYMENT, NATHANIEL A. (contact)

PROJECT_TERMS: Ablation;achilles tendon;Acute;Apoptosis;ATAC-seq;Behavior;Benchmarking;Binding Sites;Biological Assay;Botox;Cells;Center for Translational Science Activities;Chromatin;Chronic;Clinical;clinical predictors;Complement;Cytoskeleton;Data;Development;Disease;Disease Progression;Drug Targeting;Environment;Enzymes;Exhibits;experimental study;Gene Expression;Genes;Genetic Transcription;Gold;healing;Health;Health Care Costs;Homeostasis;Human;Impairment;In Vitro;in vivo;Intervention;loss of function;Matrix Metalloproteinases;mechanical signal;Mechanics;mechanotransduction;Mediating;Monitor;mouse model;mutant;Myosin ATPase;Myosin Type II;Natural regeneration;next generation;non-muscle myosin;novel;Operative Surgical Procedures;Pain;Patient-Focused Outcomes;Phase;Physical therapy;Physiological;Process;protein activation;Proteins;Rattus;rehabilitation strategy;Rehabilitation therapy;repaired;Research Project Grants;Resected;response;Role;scaffold;Signal Transduction;targeted treatment;Tendinopathy;Tendon structure;Testing;Therapeutic;Tissues;Traction Force Microscopy;transcription factor;Transcriptional Coactivator with PDZ-Binding Motif;transcriptome sequencing;translational impact;transmission process;treatment strategy;Up-Regulation

PROJECT_TITLE: Research Project 1


PI_NAMEs: HEO, SU CHIN  (contact)

PROJECT_TERMS: 3-Dimensional;achilles tendon;Address;Affect;Animals;Architecture;ATAC-seq;Biocompatible Materials;Biology;Biophysics;Bioreactors;cell behavior;Cells;Center for Translational Science Activities;ChIP-seq;Chromatin;Chromatin Structure;Clinical;Collaborations;cost;Coupled;Cues;Custom;differential expression;Disease;Disease Progression;Environment;epigenetic drug;Epigenetic Process;epigenome;epigenomic profiling;Exposure to;Extracellular Matrix;Gene Expression;Gene Expression Profile;Gene Order;Genes;Genetic Transcription;Genome;genome-wide;genome-wide analysis;genomic locus;Genomics;Goals;Histone Acetylation;Histone Deacetylase Inhibitor;histone methylation;histone modification;Histones;Human;Hydrogels;Image;imaging modality;improved;In Vitro;inhibitor;innovation;joint loading;Knowledge;mechanical load;mechanical signal;Mechanics;Modification;Molecular;Musculoskeletal;nanofiber;nanoscale;Nanoscopy;Nanostructures;novel;Nuclear;Onset of illness;Operative Surgical Procedures;osteogenic;Pathology;Pharmaceutical Preparations;Phenotype;Physical condensation;Physical environment;Physical therapy;Physiological;Play;Proteins;Protocols documentation;Recovery;repaired;Research;Research Project Grants;restoration;RNA;Role;Severities;single cell analysis;Site;soft tissue;spatiotemporal;superresolution imaging;System;Techniques;Technology;Tendinopathy;Tendon Injuries;Tendon structure;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Uses;Time;tissue degeneration;Tissue Engineering;tissue repair;Tissues;transcriptome sequencing;treatment strategy;ultra high resolution;Work

PROJECT_TITLE: Research Project 2


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Nutrition;Obesity;Pediatric;Pediatric Cancer;Physical Activity;Prevention;Rare Diseases

ORG_CITY: TAMPA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative Approximately 40-50% of off-treatment pediatric cancer survivors (PCS) are overweight or obese; thereby increasing their risk for negative long-term physical health complications. Using our successful pilot trial testing the preliminary feasibility and efficacy of NOURISH-for Healthy Transitions (NOURISH-T, 5R21CA167259) as a base, we address obesity in PCS by targeting parents as agents for change in modeling healthy eating and physical activity behaviors to promote positive PCS health behavior change and long-term healthy weight. This multi-site application addresses the public health epidemic of obesity by conducting a randomized control trial to test the efficacy of our intervention, NOURISH-T+, across a diverse sample of PCS and their parents at four pediatric oncology clinics, with the goal of establishing a framework for future translation and dissemination of NOURISH-T+.

PI_NAMEs: STERN, MARILYN  (contact)

PROGRAM_OFFICER_NAME: AGURS-COLLINS, TANYA

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Address;Adherence;adult obesity;Aftercare;Age;base;Behavior;behavior change;Behavioral;Blinded;Body mass index;Body Weight decreased;cancer therapy;Cardiovascular Diseases;Characteristics;Child;Child health care;Childhood;childhood cancer survivor;Childhood Cancer Treatment;Chronic Disease;Clinic;clinical practice;Collaborations;Data;Data Analyses;data management;Diabetes Mellitus;dietary;Dietary Assessment;Eating;Eating Behavior;effectiveness evaluation;Effectiveness of Interventions;efficacy evaluation;efficacy testing;Energy Intake;Enrollment;ethnic diversity;Exercise;Family;Fatty acid glycerol esters;Florida;follow-up;Frequencies;Future;Goals;Health;Health behavior change;Healthcare Systems;Healthy Eating;healthy weight;Height;high risk population;Hour;improved;Intake;Intervention;intervention delivery;Late Effects;Maintenance;Manuals;Measures;Medical center;Metabolic syndrome;Modeling;modifiable behavior;Obesity;Obesity Epidemic;obesity in children;obesity risk;obesity treatment;Outcome;Overweight;Pamphlets;Parents;Participant;Patient Recruitments;Patient Self-Report;Pediatric Hospitals;Pediatric Oncology;Perception;Physical activity;physical conditioning;pilot trial;Population;post intervention;Preventive;primary outcome;Public Health;racial diversity;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Reporting;Research;Research Personnel;Risk;Risk Reduction;role model;Sampling;secondary outcome;sedentary activity;Siblings;Site;sugar;Survivors;survivorship;Testing;Time;Translations;treatment as usual;Universities;Videoconferencing;Virginia;Vulnerable Populations;Waist-Hip Ratio;Weight;Weight Gain;Work;young adult

PROJECT_TITLE: NOURISH-T+: A Randomized Control Trial Targeting Parents in Promoting Healthy Eating and Exercise Behaviors in Pediatric Cancer Survivors with Overweight/Obesity

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Sleep Research;Social Determinants of Health

PHR: Project Narrative This 4-year R01 proposal will address National Institute on Aging strategic goals by testing a multilevel intervention, “Tiempo Juntos para la Salud,” (Time Together for Health) designed to promote moderate- intensity physical activity; theoretically grounded mediators; and secondary outcomes of cardiovascular health, sleep and cognitive function at 3 months, 6 months, and 12 months among 216 Spanish language-dominant Latinos aged 55 and older with MCI [Montreal Cognitive Assessment (MoCA) score ≥ 23 to 26 for Latino populations]. This study is timely given the increasing rates of Alzheimer’s disease and related dementias (ADRD) among Latinos.

PI_NAMEs: PEREZ, GLORIA ADRIANA (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Accelerometer;Address;Affect;Age;aged;Alzheimer's Disease;Alzheimer's disease related dementia;attentional control;behavior change;Behavioral;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Chronic;Cognition;Cognition Disorders;Cognitive;cognitive function;cognitive testing;Communities;Community Health Aides;community setting;cost;cost effectiveness;cultural health;Dementia;design;diabetes risk;Diastolic blood pressure;Disease;Distal;Education;effectiveness trial;Elements;empowerment;Environment;Episodic memory;ethnic minority;ethnic minority population;Ethnic Population;executive function;exercise intervention;experience;Focus Groups;Frequencies;Future;Goals;Guidelines;Health;Health behavior;health care service utilization;Health education;health outcome disparity;Heart Rate;Hour;Impaired cognition;improved;Individual;Informal Social Control;Intervention;intervention cost;Intervention Studies;Language;Latino Population;Linguistics;Low Income Population;Maintenance;Measures;Mediating;Mediation;Mediator;Metabolic syndrome;mHealth;mild cognitive impairment;Motivation;National Institute on Aging;Neighborhoods;Neurocognitive;Obesity;older adult;online resource;Outcome;Participant;Patient Self-Report;Physical activity;physical inactivity;pragmatic trial;prevent;primary outcome;Process;programs;public health priorities;racial population;Randomized;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Resources;Risk;Safety;Science;secondary outcome;sedentary;Self Perception;Short-Term Memory;Sleep;sleep onset;sleep quality;Social Environment;Social Network;Social support;Spanish;Testing;theories;therapy design;Time;Training;trial design;United States;United States National Institutes of Health;uptake;Walking;walking intervention;Work

PROJECT_TITLE: A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Introduction of drugs that inhibit the MAPK signaling pathway (MAPKi) have revolutionized treatment of children with BRAF- and NF1-driven glioma. However, tumors that harbor the BRAF(V600E) mutation either become resistant on therapy, or progress rapidly if treatment is reduced, or terminated. Thus, while MAPKi cause tumor shrinkage, they are not curative. Here we propose to develop MAPKi combinations with radiation therapy (RT) and investigate combinations that retard or prevent MAPKi/RT resistance in a unique panel of BRAF-mutant glioma mouse models.

PI_NAMEs: BURMA, SANDEEP  (contact);HOUGHTON, PETER J

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Address;Astrocytoma;BRAF gene;Brain Neoplasms;Cause of Death;Cell Death;cell killing;Central Nervous System Neoplasms;chemoradiation;Child;Childhood;Childhood Brain Neoplasm;Childhood Central Nervous System Neoplasm;Childhood Glioblastoma;Childhood Glioma;Clinical;Clinical Trials;Combined Modality Therapy;Complex;Cytotoxic agent;cytotoxicity;Data;Databases;Diffuse astrocytoma;Disease;Disease Progression;DNA Damage;Dose;driver mutation;Drug Combinations;Drug resistance;drug resistance development;Ganglioglioma;Glioblastoma;Glioma;Goals;improved;inhibitor;inhibitor therapy;Juvenile Pilocytic Astrocytomas;Laboratories;Low Dose Radiation;Malignant Neoplasms;MAP2K1 gene;MAPK Signaling Pathway Pathway;Mediating;MEKs;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinases;Modeling;mouse model;multidisciplinary;mutant;Mutation;neoplastic cell;next generation;NF1 gene;novel;Outcome;Pathway interactions;patient derived xenograft model;Patients;Pediatric Brain Tumor Consortium;pediatric low grade glioma;Pediatric Neoplasm;Pediatric Oncology Group;pediatric patients;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phase;Phase I/II Trial;phase II trial;Phosphorylation;Point Mutation;pre-clinical;preclinical study;prevent;Quality of life;Radiation Physics;radiation resistance;Radiation therapy;Regimen;Relapse;Reporting;Research;Research Personnel;Resistance;Resistance development;resistance mechanism;response;Signal Pathway;Signal Transduction;Sirolimus;targeted treatment;Testing;Therapeutic;Toxic effect;Translating;Translational Research;TSC2 gene;Tuberous Sclerosis;tumor;tumor diagnosis;tumor progression

PROJECT_TITLE: Enhancing MAPK-targeted Therapy in PDX Models of BRAF-Mutant Pediatric Brain Tumors

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Developing the optimal biocompatible matrix to maximize transplant and efficacy of tumoricidal neural stem cells (tNSCs) within the post-surgical cavity following resection of the aggressive brain cancer Glioblastoma (GBM) remains a major limitation to this promising therapy. In this proposal, we will leverage the power of Continuous Liquid Interface Printing (CLIP) to fabricate unique 3D matrices with rationally select design features, and assess the impact of different internal and external scaffold features on tNSC therapy for post- operative GBM. These results will take a critical step towards creating matrix/tNS therapies that effectively suppress post-surgical GBM in the clinical setting.

PI_NAMEs: HINGTGEN, SHAWN  (contact);PERRY, JILLIAN

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: 3-Dimensional;3D Print;Advanced Development;Allografting;Animals;anti-cancer;Architecture;Biological Assay;bioluminescence imaging;biomaterial compatibility;Biophysics;Blood - brain barrier anatomy;brain tissue;cancer cell;cancer invasiveness;cancer stem cell;cancer therapy;Cell Survival;Chemotherapy-Oncologic Procedure;Clinical;Clinical Research;clinically relevant;Coculture Techniques;Complex;copolymer;Custom;Data;Deposition;design;Enzyme-Linked Immunosorbent Assay;Excision;fabrication;first-in-human;Gelatin;gene product;Genetic Engineering;Glioblastoma;Growth;Homing;Human;Human Engineering;hydrogel scaffold;Image;Immune;Immune system;Immunocompetent;immunocytochemistry;Implant;improved;In Vitro;in vivo;Injections;Kinetics;Liquid substance;Malignant neoplasm of brain;Malignant Neoplasms;manufacture;manufacturing technology;Mechanics;Methods;Microscopic;migration;Modeling;Modulus;mouse model;Mus;Neoplasm Transplantation;nerve stem cell;novel;novel therapeutics;Operative Surgical Procedures;Patients;Penetration;Performance;permissiveness;Pharmaceutical Preparations;porous hydrogel;Postoperative Period;preclinical study;Primary Brain Neoplasms;Printing;Production;Proliferating;Property;rational design;Recurrence;Recurrent tumor;Residual Neoplasm;Residual state;Resolution;response;Safety;scaffold;Shapes;Solid;Statistical Data Interpretation;stem cell therapy;Stem cell transplant;stem cells;Surgically-Created Resection Cavity;Testing;Therapeutic;Tissues;TNF-related apoptosis-inducing ligand;Translating;Transplantation;tumor;Variant;Xenograft procedure

PROJECT_TITLE: Harnessing Continuous Liquid Interface 3D Printing to Improve Tumor-homing Stem Cell Therapy for Post-surgical Brain Cancer

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: The goal of this project is to determine how the environment in which the brain and body develop impacts cortical organization, connections and sensorimotor behavior. These studies allow us to appreciate if a dynamic and complex environment can promote behavioral flexibility, and when and how adaptive and aberrant behaviors emerge within a population.

PI_NAMEs: KRUBITZER, LEAH ANN (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Adult;Age;Anatomy;Animals;Area;ARHGEF5 gene;Behavior;Behavioral;behavioral plasticity;Birth;Body part;Brain;CDK6-associated protein p18;Complex;Coupled;Development;Discrimination;Dorsal;early experience;Electrophysiology (science);Environment;environmental enrichment for laboratory animals;Evolution;experience;experimental study;flexibility;Forelimb;Goals;grasp;Hindlimb;Individual;inter-individual variation;kinematics;Laboratories;Laboratory Rat;Learning;limb movement;Limb structure;Maps;Mediating;microstimulation;Motor;motor control;Motor Cortex;Movement;multisensory;Muscle;Neocortex;neural;Neuroanatomy;Neurons;novel;Partner in relationship;Pattern;Performance;Population;postnatal;Property;pup;Rattus;receptive field;response;Sensory;sensory cortex;Shapes;skills;somatosensory;Somatosensory Cortex;Speed;Spinal Cord;Stereotyping;Stimulus;success;synergism;System;Tactile;Tail;Techniques;Testing;Texture;Thalamic structure;Time;Walking

PROJECT_TITLE: The impact of the environment on sensorimotor cortex in rats:  Functional organization, connections and behavior

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Precision Medicine

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: The proposed study is designed to first test whether teaching people with emotion dysregulation a single emotion regulation skill in depth or multiple emotion regulation skills in less depth leads to greater decreases in daily negative emotion intensity. Second, using data from an initial sample, we will prospectively assign an independent sample of participants to receive their predicted optimal or non-optimal skill condition to determine if it is feasible and efficacious to match the participants to a single- or multiple-skill condition. Results of these studies may identify the mechanisms by which emotion regulation interventions impact emotional functioning and allow for the development of personalized, evidence-based, and scalable emotion regulation interventions.

PI_NAMEs: SOUTHWARD, MATTHEW WAYNE (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Aftercare;Algorithms;Anger;Anxiety;Articulation;behavior measurement;Behavioral;behavioral health;Behavioral Model;Borderline Personality Disorder;career;Characteristics;Clinical;Consensus;cost;Data;Dedications;depressive symptoms;design;Development;Diagnostic;Disease;Disease remission;Ecological momentary assessment;Educational process of instructing;efficacious intervention;emotion dysregulation;emotion regulation;Emotional;Emotional disorder;emotional experience;emotional functioning;Emotions;evidence base;experience;Experimental Designs;Explosion;functional outcomes;Goals;health care availability;health care service;improved;in vivo;indexing;individual patient;Influentials;Intervention;Investigational Therapies;Learning;Machine Learning;Maintenance;Mediating;Mental disorders;Mental Health;Mentored Patient-Oriented Research Career Development Award;Methods;Multimedia;National Institute of Mental Health;Nature;novel;Outcome;Participant;Patient Representative;Patient Self-Report;Patient-Focused Outcomes;Patients;Persons;Phase;Population;precision medicine;Process;Productivity;prospective;Psychopathology;Randomized;Reporting;Research;Research Domain Criteria;response;Role;Sampling;Scientist;Signal Transduction;skills;Statistical Methods;Strategic Planning;Symptoms;Techniques;Testing;Therapeutic;Time;Training;Trauma;Work

PROJECT_TITLE: A Precision Medicine Approach to Target Engagement for Emotion Regulation

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: This project investigates some of the most prominent but poorly understood aspects of the human genome, focused on most of the genome that does not code for canonical (protein-coding) genes. Emerging evidence indicates that highly repetitive and non-coding DNA is expressed and has function, and it also has organization. X-chromosome inactivation by a long non-coding XIST RNA is a powerful model, and we have evidence that XIST RNA regulates a chromosome in part by displacing or repressing repeat-rich “junk” RNA prevalent across active chromosomes. We investigate the novel hypothesis that RNA is not just a product but essentially a broad structural component of nuclear chromosomes.

PI_NAMEs: LAWRENCE, JEANNE BENTLEY (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TITLE: RNA and Genomic Junk in Fundamental Chromosome Architecture and Regulation

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Complementary and Integrative Health;Epilepsy;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Pediatric

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The aim of the proposed research is to examine the gut microbiome in mediating effects of the ketogenic diet, an intervention that has been used for nearly a century to treat refractory epilepsy, but is extremely difficult to clinically implement, maintain and tolerate due to adverse side effects. Using gnotobiotic models, integrative multi-omics approaches, and human clinical investigations of pediatric epilepsy patients, we will uncover novel molecular and cellular mechanisms linking the gut microbiota to seizure protection. Findings from these studies will advance our understanding of how the microbiota impacts health and disease, and will inform the exciting prospect of developing microbe-based therapeutics for disorders of the nervous system. !

PI_NAMEs: HSIAO, ELAINE  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Ablation;Acute;Afferent Neurons;Aftercare;Amino Acids;anti-epileptic agents;Bacteria;base;Behavior;Biological Process;Brain;Brain Diseases;brain research;Calcium;Carbohydrates;Child;childhood epilepsy;Clinical;clinical effect;clinical investigation;clinical practice;Complex;Data;Development;Diet;Diet therapy;dietary;Disease;effective therapy;Electroencephalography;Electrophysiology (science);Epilepsy;Fatty acid glycerol esters;frontier;functional genomics;gamma-Aminobutyric Acid;Glutamate Metabolism Pathway;Gnotobiotic;gut microbes;gut microbiome;gut microbiota;gut-brain axis;Health;Hippocampus;Homeostasis;host microbiome;Human;Human Microbiome;Image;Immune;Immunity;Incidence;Individual;insight;Intervention;Intractable Epilepsy;ketogenic diet;Ketone Bodies;Laboratories;Link;Mammals;Measures;Mediating;Medical History;Metabolic;Metabolism;metabolomics;Metagenomics;Methodology;Microbe;microbial;microbiome;microbiota;microbiota-gut-brain axis;microorganism;Modeling;Modification;Molecular;Molecular Biology;mouse model;multiple omics;Multivariate Analysis;Mus;Nerve;Nervous System;Nervous System Disorder;Neurobiology;Neuronal Dysfunction;Neurons;neuroregulation;Neurosciences;novel;novel strategies;nutrition;Pathway interactions;Patients;pediatric gut microbiome;Pharmaceutical Preparations;Phenotype;Physiology;Play;Predisposition;protective effect;Publications;Reporting;Research;responders and non-responders;response;Role;Seizures;Sensory;sensory mechanism;Severities;side effect;Signal Transduction;stool sample;Symptoms;Testing;Therapeutic;Tonic - clonic seizures;translational approach;Transplantation;Work

PROJECT_TITLE: Dissecting Microbiota-Gut-Brain Interactions for the Anti-Seizure Effects of the Ketogenic Diet

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE - HEALTH RELEVANCE Gaining insight into the capacity of Rpl22 to regulate HSC function through effects on metabolism will inform future efforts to devise novel strategies to exploit fatty acid oxidation (FAO) as a therapeutic vulnerability in acute myelogenous leukemia and other hematologic malignancies. In addition, these studies stand to open up new avenues for combinatorial use with cancer immunotherapy, as inhibition of FAO has been demonstrated to synergize with checkpoint blockade.

PI_NAMEs: WIEST, DAVID L. (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Ablation;Acute Myelocytic Leukemia;Address;Adult;Anemia;antagonist;arachidonate;Attenuated;attenuation;Binding;Biogenesis;Biological Process;Biology;cancer immunotherapy;cell behavior;combinatorial;Dependence;Development;Disease;Disease Progression;Distal;Dysmyelopoietic Syndromes;Embryo;Erythroid;experimental study;falls;fatty acid oxidation;fetal;Functional disorder;Future;Gene Expression;Gene Proteins;Health;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;hematopoietic stem cell emergence;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;human stem cells;Hydroxyeicosatetraenoic Acids;immune checkpoint blockade;In Vitro;insight;Knowledge;Ligands;Link;link protein;Lipids;Lipoxygenase;loss of function;Malignant Neoplasms;Mediating;Mediator;Messenger RNA;Metabolism;mouse model;mRNA Translation;Myelogenous;novel;novel strategies;novel therapeutic intervention;paralogous gene;Pathway interactions;Play;Positioning Attribute;Process;progenitor;Protein Biosynthesis;protein function;reconstitution;Regulation;Repression;Ribosomal Proteins;Ribosomes;RNA;RNA Binding;RNA Splicing;RNA Stability;Role;Signal Transduction;Specificity;stem cell biology;Stem Cell Development;stem cell function;synergism;T-Cell Development;Testing;Therapeutic;Tissues;Translations;Zebrafish

PROJECT_TITLE: Regulation of hematopoiesis by ribosomal protein paralogs

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Mental Health;Ovarian Cancer;Prevention;Rare Diseases;Rehabilitation;Rural Health;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Ovarian cancer survivors have a generally poor prognosis, and often report multiple psychosocial concerns and compromised health related quality of life (HRQOL); however, research investigating psychosocial interventions in ovarian cancer survivors has been extremely limited. The overarching goal of this project is to examine the efficacy of an innovative web-based group conferencing intervention entitled Living Well (Web-Enhanced Lessons for Living) targeting key concerns of ovarian cancer survivors vs. a Health Promotion active control intervention in a randomized controlled trial. The significance of the application is that this intervention has the potential to overcome prior barriers to the dissemination of such psychosocial interventions and improve HRQOL, thus providing public health benefits to an understudied and compromised cancer population with a high likelihood of recurrence.

PI_NAMEs: LUTGENDORF, SUSAN K (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: acceptability and feasibility;active control;Age;Animals;Anxiety;Attention;Behavioral;Biological Process;Cancer Patient;Cancer Survivor;Cancer Survivorship;Caring;Chronic;Clinic;Clinical;Cognitive;cohort;coping;Coping Skills;Data;Debility;depressive symptoms;Development;Diagnosis;direct application;Disease;Disease Progression;Distress;efficacy evaluation;Elements;evidence base;experience;Fatigue;Goals;Gynecologic Oncology;Health Benefit;Health Promotion;health related quality of life;Home;implementation barriers;improved;in vitro Model;Incidence;innovation;Internet;Intervention;intervention effect;Longterm Follow-up;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Mental Depression;mindfulness;mindfulness-based stress reduction;Moods;novel;Online Systems;Outcome;Outcome Measure;Participant;Patients;perceived stress;physical symptom;poor sleep;Population;primary outcome;Prognosis;programs;psychosocial;Public Health;Quality of life;Randomized, Controlled Trials;Recurrence;Relaxation;Reporting;Research;Rural;rural setting;secondary outcome;side effect;Site;skills;Social isolation;Stress;stress management;stress reduction;Support System;Survival Rate;Survivors;symposium;Symptoms;Targeted Research;Testing;therapy design;Time;Travel;tumor progression;Tumor Promotion;urban residence;Videoconferencing;web-based intervention;Woman;Work

PROJECT_TITLE: Living Well: A Web-based Intervention to Improve Quality of Life in Rural and Urban Ovarian Cancer Survivors

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: BOSTON

ORG_DEPT: DERMATOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Transposable elements constitute a significant part of the non-coding genome, while their role in epidermal development, homeostasis and keratinocyte differentiation remain to be elucidated. In this proposal, we will address the following questions: 1) How are transposable elements regulated in normal keratinocytes during development and terminal differentiation, 2) Which mechanisms regulate their silencing in keratinocytes, and 3) When transposable element silencing is compromised, how is epidermal development and homeostasis impacted. The generated outputs on this project will provide a platform for their translation into clinics and will promote the development of novel therapeutic interventions, which hopefully could serve as new paradigm for management of skin inflammatory conditions and their prevention.

PI_NAMEs: BOTCHKAREV, VLADIMIR A (contact);LAU, NELSON C;SHAROV, ANDREY

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Ablation;Address;Aging;Animal Genetics;Animal Model;Area;Autoimmune Diseases;autoimmune pathogenesis;Biology;Candidate Disease Gene;carcinogenesis;Cell Differentiation process;Cells;Centromere;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Clinic;Code;Collaborations;Complex;Data;Data Correlations;derepression;Development;Disease Management;Distal Enhancer Elements;DNA;DNA Methylation;DNA Methylation Regulation;DNA Modification Methylases;DNA Transposable Elements;Double-Stranded RNA;Endogenous Retroviruses;Enhancers;Epidermis;Epigenetic Process;Epithelium;Equilibrium;exhaust;Exhibits;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;Genomics;Goals;HELLS gene;Heterochromatin;histone methyltransferase;histone modification;Histones;Homeostasis;Human;Human Genome;Hyperplasia;Immune response;Immunology;Inflammatory;Inflammatory Response;Innate Immune Response;insight;keratinocyte;keratinocyte differentiation;Laboratories;Long Interspersed Elements;Lupus Erythematosus;Maintenance;Malignant Neoplasms;Maps;Mediating;member;Methylation;Minor;mouse genome;Mus;Mutant Strains Mice;Nature;novel;novel therapeutic intervention;Nucleosomes;Output;Pathologic;Patients;Pattern;Physiological;Play;postnatal;premature;prevent;Prevention;programs;promoter;Proteins;Psoriasis;Regulation;Research;Role;Signal Transduction;Site;Skin;skin organogenesis;stem cell population;stem cells;Structure;Testing;tissue regeneration;transcription factor;Transcriptional Silencer Elements;Translations;Untranslated RNA;UV Radiation Exposure

PROJECT_TITLE: Transposable elements in the keratinocyte genome and their regulation during skin development and epidermal differentiation

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Estrogen;Genetics;Neurosciences;Prevention;Stimulant Use and Misuse;Substance Misuse;Substance Misuse Prevention;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative Women are more sensitive than men to the rewarding and motivational effects of numerous drugs of abuse, including cocaine. In this proposal we test the novel hypothesis that genes on the X-chromosome lead to these behavioral sex differences. The results of these studies will reveal novel mechanisms underlying sex differences in vulnerability to cocaine addiction and help guide the development of sex-specific prevention strategies in women and men.

PI_NAMEs: LYNCH, WENDY JEAN (contact);RISSMAN, EMILIE F.

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: addiction;Adult;Alcohols;Behavior;Behavioral;Bioinformatics;Biological Assay;Brain;brain tissue;Candidate Disease Gene;Chromatin;chromatin immunoprecipitation;Chronic stress;Cocaine;Cocaine Dependence;cocaine self-administration;Code;Cognitive;Competence;Data;demethylation;design;Development;Dopamine;Drug Addiction;drug of abuse;Drug usage;drug use vulnerability;Enzymes;Epigenetic Process;Estradiol;Estrogens;Female;Four Core Genotypes;gamma-Aminobutyric Acid;Gene Expression;gene product;gene repression;Genes;Genetic;Genetic Transcription;genotypic sex;Goals;Gonadal Hormones;Gonadal structure;Grant;Histone Code;histone demethylase;histone modification;Hormonal;Human;Individual;innovation;Intervention;Intravenous;Knockout Mice;Lead;literate;male;men;Motivation;mouse model;Mus;Mutation;Neurons;novel;Nuclear;Nucleus Accumbens;Opioid Receptor;Ovarian;Ovary;overexpression;Pain;Pharmaceutical Preparations;phenomenological models;Phenotype;Ploidies;Prefrontal Cortex;Prevention;Prevention strategy;programs;Prosencephalon;Regulation;Research;Research Personnel;response;Rewards;Risk;Rodent;Role;Running;Self Administration;Serotonin;sex;Sex Chromosomes;Sex Differences;Testing;Testis;Tissues;transcription factor;Transposase;Woman;women versus men;Work;X Chromosome;X Inactivation

PROJECT_TITLE: Genetic and hormonal contributions to sex differences in vulnerability to drug use


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because identifying affordable and easily implemented tools to establish the correct diagnosis and treatment of diabetes in children of diverse racial and ethnic background in a timely fashion is ultimately expected to lower the risk of acute and chronic complications of diabetes, which largely contribute to the estimated yearly costs over $327 billion of this disease of increasing incidence. Thus, the proposed research is relevant to the part of the NIDDK's mission that pertains to conducting medical research on diabetes to improve people's health and quality of life.

PI_NAMEs: REDONDO, MARIA JOSE (contact)

PROGRAM_OFFICER_NAME: AKOLKAR, BEENA

PROJECT_TERMS: accurate diagnosis;Acute;Address;Adult;Affect;African;African American population;African ancestry;Age;Beta Cell;blood glucose regulation;Body mass index;C-Peptide;Caucasians;Cell Physiology;Characteristics;Child;Childhood;Childhood diabetes;Chronic;Classification;Clinical;Clinical Management;clinically relevant;Cohort Studies;Collaborations;Complications of Diabetes Mellitus;cost;Data;Dependence;design;Development;diabetes control;Diabetes Mellitus;Diabetic Ketoacidosis;Diagnosis;Diet;Disadvantaged;Disease;economic cost;ethnic diversity;ethnic minority;Ethnic Origin;Ethnic Population;Frequencies;Genetic;Genetic Risk;genetic testing;Goals;Health;Hispanic Populations;improved;improved outcome;Incidence;Individual;innovation;Insulin;Insulin deficiency;Insulin-Dependent Diabetes Mellitus;islet cell antibody;longitudinal design;Measures;Medical Research;minority children;Mission;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;Oral;Outcome;Performance;Persons;Pharmaceutical Preparations;Phenotype;Physicians;predictive modeling;Predisposition;prospective;Public Health;Quality of life;Race;racial disparity;racial diversity;racial minority;racial population;Research;Residual state;Risk;Risk Reduction;Sampling;screening;SNP genotyping;Testing;Time;tool;Treatment outcome;type I and type II diabetes;Youth

PROJECT_TITLE: Type 1 diabetes genetic risk scores for the diagnosis of diabetes type in children of diverse racial and ethnic background

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Estrogen;Menopause;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: COLUMBIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Post-menopausal replacement of estrogen is controversial and may pose unwanted health risks. Thus, a natural therapy (8-Prenylnaringenin) that could be both safe AND effective at combating estrogen-deficient side effects is of critical public health relevance and importance. This research will lay the groundwork for the future use of 8-Prenylnaringenin as a therapy for the negative health side effects linked to estrogen deficiency.

PI_NAMEs: ENOS, REILLY  (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Adipose tissue;Alternative Therapies;Anti-Inflammatory Agents;Biological Availability;Blood Chemical Analysis;Body Weight Changes;career;Cells;Chronic Disease;Clinical Treatment;Clinical Trials;Data;Dose;Drug Kinetics;effective therapy;ESR1 gene;Estrogen deficiency;Estrogen Replacements;Estrogen Therapy;Estrogens;Exhibits;experience;experimental study;falls;Fatty acid glycerol esters;Female;Foundations;Future;Glucose Clamp;glucose metabolism;glucose uptake;Goals;Health;Health Sciences;High Risk Woman;Hormone replacement therapy;Humulus;Hyperinsulinism;Immunologic Monitoring;Impairment;in vivo;Inflammation;Inflammatory;inflammatory milieu;innovation;insulin sensitivity;insulin sensitizing drugs;Investigation;Investments;Knockout Mice;Link;Lupus;Macrophage;Malignant Neoplasms;Mediating;Mediator;Menopause;Menstruation;Metabolic;Modeling;mortality risk;Mus;Muscle;Muscle Fibers;Myocardial Infarction;National Center for Complementary and Integrative Health;Obesity;obesity risk;Ovarian;Ovariectomy;Pathologic;Phenotype;Phytoestrogens;Plants;Postmenopause;pre-clinical;Process;public health relevance;Publishing;Radioisotopes;Research;response;Risk;Rodent Model;side effect;Signal Transduction;Skeletal Muscle;Strategic Planning;stroke risk;Supplementation;Techniques;Technology;Testing;Therapeutic;Therapeutic Effect;therapy development;Tissues;Toxic effect;Toxicology;Tracer;Training;United States National Institutes of Health;Woman;Women's Health;Work

PROJECT_TITLE: 8-Prenylnaringenin:  A Natural Therapy for Estrogen Deficiency


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

PHR: Project Narrative In older adults, diminished sensation of the legs and feet is highly prevalent and causes poor balance and reduced mobility. This type of sensation is not only dependent upon the receptors and nerves in the legs and feet, but also upon a complex central nervous system pathway that includes the cerebral cortex of the brain. This project will use a form of noninvasive brain stimulation called transcranial direct current stimulation (tDCS) to test whether increasing the excitability of the brain networks that process sensory feedback can augment foot sole sensation, balance, and mobility in older adults suffering from mild-to-moderate foot sole sensory impairments.

PI_NAMEs: ZHOU, JUNHONG  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acute;Age;age related;Aging;blood oxygenation level dependent response;Brain;career;Central Nervous System;Cerebral cortex;Chronic;Clinical;clinical care;cognitive function;comparison control;Complex;Contralateral;Custom;Data;design;Diffuse;Disease;Dose;Double-Blind Method;electric field;Electrodes;Elements;Equilibrium;Esthesia;Exhibits;experience;Fall prevention;fall risk;falls;foot;foot sole;Functional Magnetic Resonance Imaging;functional restoration;Gait;Goals;Impairment;improved;Intervention;K-Series Research Career Programs;Knowledge;Learning;Left;Leg;locomotor control;Lower Extremity;Magnetic Resonance Imaging;Measures;Mentored Research Scientist Development Award;Mobility decline;Modeling;Nerve;Nervous System Physiology;neuroimaging;neurophysiology;noninvasive brain stimulation;novel;novel therapeutics;older adult;Participant;Pathway interactions;Peripheral;Peripheral Nerves;Peripheral Nervous System;Population;Porifera;pressure;Process;programs;Protocols documentation;Randomized;receptor;Research;response;Scalp structure;Scientist;screening;sensory feedback;Sensory impairment;Sensory Process;somatosensory;Somatosensory Cortex;Specific qualifier value;Stimulus;System;tactile stimulation;Techniques;Technology;Testing;Therapeutic;therapy design;Training;transcranial direct current stimulation;transmission process;Visit;Walking;Work

PROJECT_TITLE: Cortical mechanisms and modulation of somatosensation in older adults with foot sole somatosensory impairments

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Pathological trauma-related dissociation is a significant personal and societal burden. This proposal will examine behavioral and biological correlates of dissociation across imaging, physiology, and digital assessments. Results from this proposal will inform how to identify those at risk for these debilitating symptoms, potential brain regions to target for treatment, and may support a new standard of clinical care for PTSD with dissociation.

PI_NAMEs: KAUFMAN, MILISSA L (contact)

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: Adult;Aftercare;Amnesia;Anterior;Arousal;Attention;Behavioral;Biological;Biological Markers;Biology;Brain;Brain region;Childhood;Clinical;clinical care;Clinical Trials;Complex;Computer Models;cost;Data;debilitating symptom;Depersonalization;Derealizations;Diagnosis;diagnostic criteria;digital;digital assessment;Digital biomarker;digital phenotyping;Dimensions;Disabling;Disease;Dissociation;Dorsal;Ecological momentary assessment;emotion regulation;Emotional;Environment;Equipment and supply inventories;Evidence based treatment;Exhibits;Fright;Future;Goals;heart rate variability;Image;Individual;Intervention;Learning;Machine Learning;Magnetic Resonance Imaging;Maps;Measures;Medial;Mental disorders;Modality;Modeling;multimodal data;multimodality;Nature;neural;Neurobiology;neuroimaging;novel;Numbness;Participant;Pathologic;Patient Self-Report;Patients;pediatric trauma;Phase;Phenotype;phenotypic data;Physiological;Physiology;Post-Traumatic Stress Disorders;predictive modeling;Prefrontal Cortex;Process;Psychometrics;Psychophysiology;Recording of previous events;Recovery;Reflex action;Refractory;Regulation;Relapse;respiratory;response;Rest;Risk;Role;Self Destructive Behavior;Sinus Arrhythmia;skills;standard of care;suicidal;Symptoms;System;targeted biomarker;targeted therapy trials;Time;Trauma;trauma exposure;Work

PROJECT_TITLE: Multimodal Approaches to Neurobiology of Traumatic Dissociation

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative This project evaluates biomarkers carried by tumor-derived extracellular vesicles for efficacy in stratifying patients with pancreatic cysts into categories of high-probability and low-probability for the presence of pancreatic cancer, thereby identifying patients who would benefit from an invasive fine needle aspiration biopsy of the pancreas. The use of label-free high conductance dielectrophoresis technology will enable simultaneous recovery of these different nanoparticle types from plasma for biomarker detection. This research will generate new knowledge supporting the development of a nanoparticle-based biomarker panel for the detection of pancreatic cancer while also helping to enable the use of nanoparticle-based biomarkers for diagnostic applications in the clinic.

PI_NAMEs: IBSEN, STUART DUNCAN (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: acute pancreatitis;Address;Benign;Biological Markers;biomarker panel;Blinded;Blood;Blood Plasma Volume;Blood Tests;blood-based biomarker;CA-19-9 Antigen;Cancer Detection;Cancer Patient;cancer type;candidate marker;Categories;Circulation;Clinic;Clinical;clinical development;Cohort Studies;Collection;cost;Cyst;Cytolysis;Data;Death Rate;Dependence;Detection;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Disease;early detection biomarkers;efficacy evaluation;Endoscopic Ultrasonography;Evaluation;exosome;extracellular vesicles;Financial cost;Fine needle aspiration biopsy;follow-up;Frequencies;Health;High Resolution Computed Tomography;Hypoxia;Image;Imaging Techniques;Individual;Investigation;Knowledge;Label;Lesion;Lipids;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Malignant Neoplasms;Methods;Microelectrodes;Microfluidic Microchips;Monitor;nanoparticle;Necrosis;novel;Organelles;Pancreas;pancreatic cancer patients;Pancreatic Cyst;Pancreatic Diseases;Pancreatic Ductal Adenocarcinoma;particle;patient stratification;Patients;Plasma;premalignant;Probability;Procedures;protein biomarkers;Proteins;Recovery;Research;Research Personnel;Retrospective cohort;Risk;Sampling;screening;Source;Symptoms;Techniques;Technology;technology platform;Time;Translating;tumor;Tumor-Derived;Validation;Work

PROJECT_TITLE: Distinguishing Pancreatic Cancer from Benign Pancreatic Disease using Nanoparticle-based Biomarkers

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: The proposed research is relevant to public health, because dysregulated alternative splicing leads to a broad range of diseases, including many cancers and neurological disorders. Our proposed research will shed light on how splicing is regulated, which could reveal novel therapeutic strategies to rescue disease-causing splicing defects. As such, the proposed research is relevant to the part of the NIH's mission that seeks to develop fundamental knowledge to inform our diagnosis and treatment of human disease.

PI_NAMEs: CHURCHMAN, LEE STIRLING (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affect;Alternative Splicing;Binding;Biological Assay;Cell Differentiation process;Cells;Chromatin;cis acting element;Computer Analysis;CRISPR/Cas technology;crosslink;Cytoplasm;Data;Defect;Diagnosis;differentiation in vitro;Disease;DNA-Directed RNA Polymerase;Elements;Excision;Exons;experience;experimental study;Frequencies;Genes;Genetic;Genetic Transcription;genetic variant;genome-wide;Genomics;Goals;Grant;Hour;Human;human disease;Human Genome;Immunoprecipitation;in vivo;in vivo evaluation;Individual;insight;Introns;Kinetics;Knowledge;Length;Link;Malignant Neoplasms;Measures;Methods;Mission;Modeling;Muscle;Muscle Fibers;Muscular Dystrophies;Myoblasts;myogenesis;nanopore;Nervous System Disorder;Neurodegenerative Disorders;novel therapeutic intervention;Nucleoplasm;Nucleotides;Outcome;Positioning Attribute;Process;Processed Genes;Proteins;Public Health;Regulation;Research;Resolution;RNA;RNA purification;RNA Sequences;RNA Splicing;RNA-Binding Proteins;Role;Site;Spliceosomes;System;Techniques;Time;Tissues;tool;Trans-Activators;Transcript;transcriptome sequencing;United States National Institutes of Health

PROJECT_TITLE: Global control of co-transcriptional splicing

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Prevention

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: The proposed research is relevant to public health because Crohn’s Disease, increasing in prevalence, consists of poorly defined sub-phenotypes that require better classification in order to optimize therapeutic intervention. Propensity for ileal fibrosis and recurrent disease, one such sub-phenotype, is a complication present in 30% of CD patients, and will ultimately require surgery in as much as 75% of these individuals. No approved therapeutic exists to prevent or manage fibrosis, therefore findings from this study, which will characterize the fibrotic sub- phenotype based on host genetics, microbiome, and peri-intestinal mileiu will open a new avenue for developing therapeutic interventions.

PI_NAMEs: DEVKOTA, SUZANNE  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Adipose tissue;Attenuated;Automobile Driving;Bacteria;Bacterial Translocation;Biological;Biology;Biopsy;Blood;cell type;Cells;Chronic;Classification;clinically relevant;Collagen;Collection;Complex;Complication;Crohn's disease;Data;Deposition;Development;Disease;Environment;Excision;Face;Famines;Fatty acid glycerol esters;Feces;Fibroblasts;Fibrosis;Fingers;fungus;Future;Genes;Genetic;Genetic Predisposition to Disease;Genotype;Germ-Free;Goals;grasp;gut inflammation;gut microbiota;high risk;Hyperplasia;ileum;Immune;immune activation;Immune response;Immunologics;Individual;Inflammation;innovation;insight;Intervention;Intestinal Fibrosis;Intestines;Left;Macrophage;Mediating;Mesentery;metabolome;metabolomics;Metagenomics;microbial;microbiome;microbiome research;microbiota;microbiota profiles;microorganism;Modeling;Mucous Membrane;Mus;Myelogenous;Newly Diagnosed;novel therapeutics;Operative Surgical Procedures;Organism;overexpression;Patient Care;patient subsets;Patients;Pattern;Penetrance;Pharmaceutical Preparations;Phenotype;Physiological Processes;Play;Pliability;polygenic risk score;Population;Postoperative Period;Predisposition;Prevalence;prevent;Process;programs;Public Health;Recurrence;Recurrent disease;Repeat Surgery;Research;response;Risk;Role;screening;Severities;single-cell RNA sequencing;Site;Small Intestines;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;Transgenic Mice;Visual

PROJECT_TITLE: Role of microbiota, host genetics and mesenteric adipose in Crohn's disease fibrosis and post-op recurrence.

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Microbiome;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Smokers with Kras-mutant lung adenocarcinoma (KM-LUAD) display very poor clinical outcome largely due to our poor understanding of targetable molecular changes in the development of the malignancy. While it is now appreciated that the host microbiome has a major impact on health and is a key orchestrator of tumor promoting inflammation and cancer therapy, the role of microbiome changes in development of KM-LUAD is not known. Using unique human-relevant experimental models as well as state-of-the-art metagenomics, immune profiling, and computation, we propose to first interrogate how the gut, and possibly lung, microbiome sways KM-LUAD pathogenesis, pro-tumor inflammatory pathways and tumor immunity and then to develop and test gut microbiome intervention strategies that prevent development of this fatal disease.

PI_NAMEs: KADARA, HUMAM  (contact);MOGHADDAM, SEYED JAVAD MIRHASSANI

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: 16S ribosomal RNA sequencing;4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone;Animals;Antibiotics;Antibodies;antimicrobial;Bioinformatics;cancer diagnosis;Cancer Patient;cancer therapy;Carcinogen exposure;Cells;Chemoprevention;Chemopreventive Agent;cigarette smoke;Clinical;combustible cigarette;Cues;Data;Development;Disease;Early Diagnosis;Early treatment;Event;Evolution;Exhibits;Experimental Models;Exposure to;exposure to cigarette smoke;Fostering;G-Protein-Coupled Receptors;Genetic;Genetically Engineered Mouse;Global Change;gut microbiome;Health;Host Defense;host microbiome;Human;Immune;immune checkpoint;Immune response;Immunology;immunoregulation;Immunotherapeutic agent;Immunotherapy;Inferior;Inflammation;Inflammatory;insight;Interleukin-6;Intervention;Ketones;Knock-out;LCN2 gene;Link;Lung;Lung Adenocarcinoma;Lung immune response;lung microbiome;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metagenomics;microbial;microbiome;microbiome composition;microbiome therapeutics;Modality;Molecular;mouse model;Mus;mutant;Mutation;Neoadjuvant Therapy;Nicotine;Nitrosamines;novel;nursing mothers;Oncogenes;Outcome;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;Phenotype;prevent;Prevention strategy;probiotic supplementation;Process;Prognosis;programmed cell death protein 1;programs;Proteins;Pulmonary Inflammation;Reporting;response;Role;Signal Transduction;Smoker;Smoking;Somatic Mutation;STAT3 gene;statistics;stool sample;Structure of parenchyma of lung;Study models;T-Lymphocyte;Taxonomy;Testing;Therapeutic Effect;Time;Tobacco;tobacco exposure;Tobacco-Associated Carcinogen;treatment response;tumor;Tumor Immunity;tumor progression;Tumor Promotion;tumorigenesis;United States;Up-Regulation;Variant;Volatile Fatty Acids;Wild Type Mouse

PROJECT_TITLE: Interplay between host microbiome and immunomodulatory responses in the pathogenesis of Kras mutant lung cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Cocaine;Depression;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Precision Medicine;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse;Violence Research;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Early life stress (ELS) is a major risk factor for cocaine (COC) use disorder (CUD), but it is unclear how ELS and COC abuse during adolescence interact to alter brain development to increase vulnerability to CUD during adulthood. The goal of this proposal is to examine long-term impact of ELS on neurobiological systems that increase risk to CUD during adulthood, using a unique and highly translational nonhuman primate (NHP) model of ELS (infant maltreatment) with adolescence COC self-administration and addressing sex differences. These prospective, longitudinal studies in NHPs are critical to identify the neurobiological mechanisms of risk of CUDs and lifelong addiction, including relapse following abstinence, and to develop pharmacological interventions that target dopamine and serotonin receptors specifically for at-risk populations.

PI_NAMEs: NADER, MICHAEL A;SANCHEZ, MAR M (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;addiction;Address;Adolescence;Adolescent;Adult;Adverse event;Affect;Age;Amygdaloid structure;Animals;Anxiety;Behavioral;Birth;Brain;Brain region;Child Abuse and Neglect;Child Development;Chronic;Cocaine;Cocaine Abuse;Cocaine Dependence;cocaine exposure;cocaine self-administration;cocaine use;Cocaine use disorder;cognitive development;cohort;comorbidity;comparison control;Control Animal;Data;Development;Dopamine;Dopamine Receptor;Drug abuse;Drug Addiction;Drug usage;early life stress;Effectiveness;emotion regulation;Emotional;Emotions;experience;Female;fetal drug exposure;Funding;Goals;Health Care Costs;Heritability;Human;in vivo;Individual;infant maltreatment;Intake;Intervention;Life;long term abstinence;longitudinal, prospective study;Macaca;Macaca mulatta;Magnetic Resonance Imaging;male;maltreatment;Measures;Mental Depression;Modeling;Monkeys;National Institute of Drug Abuse;neurobiological mechanism;Neurobiology;neuroimaging;Neuronal Plasticity;nonhuman primate;novel;Nucleus Accumbens;personalized medicine;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Population;Populations at Risk;Positron-Emission Tomography;Prefrontal Cortex;Process;Psychological reinforcement;Psychopathology;receptor;Recording of previous events;Recovery;Reinforcement Schedule;Relapse;Reporting;Research;response;Rewards;Risk;Risk Factors;Serotonin;serotonin receptor;sex;Sex Differences;Social status;societal costs;Stress;Substance Use Disorder;System;treatment strategy;United States National Institutes of Health;Ventral Striatum;Woman;women versus men

PROJECT_TITLE: Early Life Stress, Chronic Drug Use and Neuroplasticity in Nonhuman Primate Models of Cocaine Abuse: Relevance to Treatment Strategies

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE The diversity, population size, and health challenges of metropolitan Houston provides an ideal setting for a new NIDA R25: Providing Research Education Experiences to Enhance Diversity in the Next Generation of Substance Abuse and Addiction Scientists. The University of Houston (UH) will leverage its Helping Everyone Achieve a LifeTime of Health (HEALTH) Research Institute and NIMHD RCMI (HEALTH Center for Addictions Research and Cancer Prevention) to serve as the platform for executing an innovative substance abuse research education program to the future generation of scientists underrepresented in the biomedical, behavioral, clinical, and social sciences. The HEALTH – Future Addiction Scientist Training (HEALTH – FAST) Program will leverage a transdisciplinary approach to health-equity science with a focus on how substance use/abuse leads to chronic diseases that disproportionately affect health-disparity populations.

PI_NAMEs: OBASI, EZEMENARI M;REITZEL, LORRAINE R (contact)

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: Acceleration;addiction;Address;Affect;alcohol tobacco and other drug use;Applications Grants;Area;Asian;Asian Americans;ATOD;Behavior;Behavioral Sciences;Biochemistry;Biology;Biomedical Engineering;Black race;cancer prevention;career;Career Mobility;Chronic Disease;Clinical Sciences;college;Communities;comorbidity;Computers;Data;Degree program;design;Development;Development Plans;disadvantaged background;disease disparity;Disparity;Disparity population;Education;education research;Educational Curriculum;Educational Status;Engineering;Enrollment;Ensure;ethnic diversity;ethnic minority;Event;Evidence based intervention;experience;Faculty;faculty mentor;Feedback;Funding;Future;Future Generations;Grant;Health;health disparity;health disparity populations;health equity;health science research;Health Sciences;Health system;Hispanic-serving Institution;Human;improved;Individual;innovation;Institution;Interdisciplinary Study;Investments;Journals;Knowledge;Latinx;Learning;Location;Manuscripts;Maps;matriculation;Medical center;meetings;Mentors;metropolitan;Modification;National Institute of Drug Abuse;National Institute on Minority Health and Health Disparities;Native Americans;next generation;novel;Outcome;Pacific Island Americans;Peer Review;Performance;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Policies;Population;population health;Population Sizes;Postdoctoral Fellow;Preparation;Process;Productivity;Program Evaluation;Program Reviews;programs;protective factors;psychologic;Psychology;Public Health;Publications;Qualifying;racial minority;Research;Research Activity;research faculty;Research Institute;Research Personnel;Research Training;Resources;responsible research conduct;Risk;Science;Scientist;Secure;Series;skills;Social Sciences;Social Work;Substance abuse problem;Substance Addiction;substance use;substance use prevention;Texas;Time;trafficking;Training;Training and Education;Training Programs;trend;Underrepresented Populations;Universities;vulnerable community;Woman;Work;Writing

PROJECT_TITLE: Helping Everyone Achieve a LifeTime of Health - Future Addiction Scientist Training


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

PHR: Project Narrative Recent advances in Alzheimer’s research has highlighted the need for preventing disease rather than treating symptoms. As we get closer to achieving effective treatments, there is an urgent need for tools that will allow us to identify individuals at risk of developing disease in order to deliver appropriate interventions. The Emory Healthy Brain Study will follow a large (≥3000) and racially diverse (1/3 African-American) group of healthy 50- to 75-year-old individuals over time with collection and analysis of blood, cerebrospinal fluid, and brain MRI scans to develop predictive tests to guide preventive treatments.

PI_NAMEs: LAH, JAMES J (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Acceleration;Address;African American;African American population;Age;aged;aging population;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;Area;arterial stiffness;asymptomatic Alzheimer's disease;Biological Markers;biomarker discovery;biomarker identification;Blood;Blood Vessels;Brain;brain magnetic resonance imaging;candidate identification;candidate marker;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;Carotid Atherosclerotic Disease;Caucasians;Central Nervous System;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;cerebrovascular;Characteristics;Chronic Disease;Classification;Clinical;clinical phenotype;clinical practice;Cognitive;cognitive testing;cohort;Collection;Data;data sharing;Detection;Diagnosis;Disease;effective therapy;Enrollment;Etiology;Evolution;Exposure to;follow-up;Frequencies;Functional disorder;Future;Genotype;Goals;high risk;Hormone replacement therapy;imaging modality;immune function;Immunity;Impaired cognition;Individual;Inflammation;Intervention;longitudinal analysis;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Magnetic Resonance Spectroscopy;Measurement;Measures;Metabolic;middle age;MRI Scans;Myelin;myelination;neuroinflammation;Neurons;novel marker;Older Population;Participant;Pathology;Patients;Phenotype;Positron-Emission Tomography;pre-clinical;predictive marker;predictive test;prevent;Prevention trial;Preventive treatment;protein biomarkers;Proteins;Proteomics;Race;racial difference;racial diversity;recruit;Research;Research Personnel;Resources;Risk;risk prediction;Role;Science;sex;Sex Differences;Statistical Methods;Subgroup;support tools;symptom treatment;Symptoms;Synapses;tau Proteins;Techniques;Testing;Time;tool;Tracer;Work

PROJECT_TITLE: The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's Disease


ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Our studies define the genes and molecules that guide the generation of B cells, which are the blood cells that make antibodies that protect us from infections. Instead of making protective antibodies, some B cells make autoantibodies that can lead the immune system to mount autoimmune responses that cause diseases. Generally, these autoreactive B cells are few and inert, but they are more abundant in individuals predisposed to autoimmunity. Our studies aim to define the molecular process that leads to the overproduction of autoreactive B cells, predisposing to autoimmunity.

PI_NAMEs: PELANDA, ROBERTA  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Antibodies;Antibody-mediated protection;antigen binding;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Responses;Autoimmunity;autoreactive B cell;autoreactivity;Avidity;B cell repertoire;B-Cell Development;B-Lymphocytes;Biochemical Pathway;Blood;Blood Cells;Bone Marrow;Cell Differentiation process;Cells;central tolerance;chemokine receptor;Circulation;Clonal Deletion;CXCR4 gene;Data;Defect;Development;differentiation in vitro;Disease;dominant active;Dominant-Negative Mutation;Ectopic Expression;Exclusion;Exhibits;experimental study;Family;FOXO1A gene;gain of function;gain of function mutation;Gatekeeping;Generations;Genes;Genetic;Goals;Grant;Guanosine Triphosphate Phosphohydrolases;Human;Immune system;Immune Tolerance;Immunoglobulin Genes;in vivo;Individual;Infection;Knock-in Mouse;Knowledge;Lead;Lipids;MAPK3 gene;Mediating;Mediator;MEKs;Mitogen-Activated Protein Kinases;Molecular;Motion;mouse model;Mus;Mutation;novel strategies;Pathway interactions;Patients;peripheral tolerance;Phosphotransferases;PIK3CG gene;prevent;Process;Production;programs;Proto-Oncogene Proteins c-akt;Publishing;receptor;Research;Risk;RNA;Role;Signal Pathway;Signaling Molecule;Testing;transcription factor;transcriptome sequencing;Transitional Cell;Translating

PROJECT_TITLE: Role and mechanisms of the PI3K pathway in B cell tolerance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(02)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Disability Research;Genetics;Hearing Loss;Machine Learning and Artificial Intelligence;Prevention;Rehabilitation

ORG_DEPT: OTOLARYNGOLOGY

PHR: Project Narrative In this grant, we will: leverage a purpose-built tool, AudioGene, and comprehensive genetic testing using OtoSCOPE to complete gene-specific natural history studies of non-syndromic forms of hearing loss; refine ACMG guidelines for hearing loss by making them gene specific and by implementing a combination of deep learning and physics-based protein modeling to improve variant classification; and identify genetic modifiers of select types of non-syndromic hearing loss. Completion of this grant will refine our understanding of the biology of hearing and deafness, improve the clinical care of persons with hearing loss, facilitate the design of clinical trials to test novel therapies to treat gene-specific types of hearing loss, provide a strong foundation for gene- based precision medicine for the hearing impaired, and potentially identify new targets for gene therapy for deafness.

PI_NAMEs: BRAUN, TERRY A;CASAVANT, THOMAS L.;SCHNIEDERS, MICHAEL JOHN;SMITH, RICHARD J.H. (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Address;Affect;Artificial Intelligence;Audiology;Binding Proteins;Biology;Caring;Classification;Clinical;Clinical assessments;clinical care;clinical diagnostics;Clinical Trials Design;cost;Data;Databases;deaf;deafness;deep learning;Developed Countries;Diagnostic tests;Disease;DNA Sequence;Ethnic Origin;Etiology;Evaluation;Foundations;Free Energy;gene-targeted therapy;Generations;Genes;Genetic;genetic analysis;genetic deafness;genetic testing;Genome;Genotype;Goals;Grant;Guidelines;hard of hearing;Hearing;hearing impairment;hearing loss phenotype;Hearing Tests;hereditary hearing loss;Human;improved;insight;Knowledge;Machine Learning;Methods;Modeling;mouse model;Natural History;novel;novel therapeutics;Otoscopes;Persons;phenome;Phenotype;Physical Examination;Physics;Population;Population Study;precision medicine;protein folding;Proteins;Quality of life;Recording of previous events;Reporting;research clinical testing;Sensory;software systems;supervised learning;Surface;Techniques;Testing;tool;Variant;Work

PROJECT_TITLE: Optimizing Genetic Testing for Deafness for Clinical Diagnostics

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases

PHR: Glioblastoma is a deadly disease with no effective therapeutic options. We have identified a cancer-driving factor, to which glioblastoma cells are addicted. In this application, we propose the systematic investigation of targeting this factor as a novel approach against GBMs.

PI_NAMEs: LI, HUI  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Actins;Adult;Affect;aggressive therapy;angiogenesis;Animal Model;Animals;anti-tumor immune response;Astrocytes;Automobile Driving;Avil;AVIL gene;Binding;Biochemical;Biological Assay;Biological Markers;Biophysics;brain tissue;cancer type;CDK4 gene;Cell Culture System;Cell Culture Techniques;Cell Line;cell motility;Cell Proliferation;Cell Survival;Cells;Childhood Rhabdomyosarcoma;Clinical;cohort;Complex;Contact Inhibition;Data;Development;Disease;efficacy evaluation;efficacy testing;Event;F-Actin;Fibroblasts;follow-up;FOXM1 gene;Gene Fusion;Glioblastoma;Glioma;Goals;Human;In Vitro;in vivo;Investigation;Knock-out;Knockout Mice;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;MDM2 gene;Measures;Mediating;Modeling;mouse model;multimodality;Mus;Mutation;neoplastic cell;nerve stem cell;new therapeutic target;novel;novel strategies;novel therapeutic intervention;oncogene addiction;Oncogenes;Oncogenic;Operative Surgical Procedures;overexpression;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Phenocopy;Point Mutation;Predisposition;Primary Brain Neoplasms;Prognosis;Proteins;Radiation;rational design;Resistance;resistance mechanism;Role;Safety;Sampling;screening;small hairpin RNA;Small Interfering RNA;small molecule;small molecule inhibitor;Source;stem;stem cells;targeted cancer therapy;targeted treatment;Testing;Tetanus Helper Peptide;therapeutic biomarker;therapeutic target;therapeutically effective;transcriptome;Treatment Efficacy;treatment planning;tumor;tumor microenvironment;tumorigenesis;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting AVIL in Glioblastoma

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Infant Mortality;Pediatric;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE In the US, the most common cause of death in infants is birth defects. In the past, environmental exposures were thought to be an important contributor to birth defects, but recently, it is becoming clear that changes in our genes can also lead to birth defects. In this proposal, we will analyze a large set of genes that may cause congenital heart disease, or “holes in the heart” a particularly life-threatening form of birth defect.

PI_NAMEs: KHOKHA, MUSTAFA K (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Aborted Fetus;Adult;Affect;Alleles;Animal Model;Applications Grants;Biological Assay;Biological Process;Breathing;Candidate Disease Gene;Cardiac;cardiogenesis;Caring;Cause of Death;Child Health;Cilia;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Congenital Abnormality;congenital heart abnormality;Critical Pathways;Data;de novo mutation;Development;Developmental Gene;Diagnostic;Diploidy;Disease;disease phenotype;Embryo;Embryonic Development;Environmental Exposure;Etiology;Europe;experience;Extracellular Fluid;Failure;fascinate;Fatal birth defect;fluid flow;Funding;gain of function;gene discovery;Genes;Genetic;genetic analysis;Genetic Predisposition to Disease;Genomics;Goals;Grant;Heart;Human;Human Genetics;human genomics;immunodeficiency;Incidence;Infant Mortality;Inherited;insight;Investigation;Left;Life;Live Birth;loss of function;Messenger RNA;Modeling;Molecular;molecular marker;mutant;new technology;next generation;notch protein;novel;Operative Surgical Procedures;Organ;Output;overexpression;Pathogenesis;Pathogenicity;Pathway interactions;Patient Care;Patients;Pattern;Phenocopy;Phenotype;Population;Process;Publications;Publishing;Rana;Research Personnel;Role;screening;sharing platform;Signal Pathway;Signal Transduction;Situs Inversus;statistics;Structure;System;Techniques;Testing;Therapeutic;Transforming Growth Factor beta;Translating;Variant;Work;Xenopus

PROJECT_TITLE: A system approach to the analysis of Heterotaxy Candidate Genes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The ability to make effective decisions is a crucial for health and wellbeing, but can be severely impaired by Alzheimer's and cognitive decline. Work in this grant will uncover the cognitive and neural mechanisms underlying a particular type of decision and how these mechanisms change in healthy aging. This work is relevant to public health as it will provide a framework for understanding the decision-making changes in healthy aging, cognitive decline and Alzheimer's which will help to improve health, functional independence, and wellbeing in older adults.

PI_NAMEs: WILSON, ROBERT C (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Adult;Age;age difference;age effect;age group;age related;age related changes;Aging;aging process;Alzheimer's Disease;anatomic imaging;Anterior;Area;Behavior;behavior test;Behavioral;Brain;Brain Mapping;Cephalic;Chronic Disease;cingulate cortex;Cognitive;cognitive function;Data;Decision Making;Diffusion Magnetic Resonance Imaging;discounting;Dorsal;Equilibrium;experimental study;functional independence;Functional Magnetic Resonance Imaging;Future;Grant;Health;health plan;healthy aging;human old age (65+);Impaired cognition;Impairment;improved;Individual Differences;Inferior frontal gyrus;innovation;Insula of Reil;Investments;Life;life span;Location;Love;Magnetic Resonance Imaging;Magnetism;Mathematics;Measures;Modeling;neural;neural correlate;neural stimulation;neuroimaging;neuromechanism;older adult;Outcome;Personal Satisfaction;Persons;predictive modeling;Public Health;repetitive transcranial magnetic stimulation;Research;Restaurants;Retirement;Risk;Role;Sampling;Savings;side effect;Structure;System;Testing;Transcranial magnetic stimulation;Work;young adult

PROJECT_TITLE: Evaluating the Neurocomputational Mechanisms of Explore-Exploit Decision Making in Older Adults

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Genetics;Human Genome;Patient Safety;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative A major challenge for patients with immune diseases is the delay in diagnosis that leads to morbidity and mortality. This proposal combines teams from the five medical centers of the University of California and Vanderbilt to apply advanced computational, machine-learning approaches to identify patients with genetic immunodeficiency diseases. This approach will dramatically improve the care of otherwise-neglected patients with rare diseases.

PI_NAMEs: BUTTE, MANISH J (contact);PASANIUC, BOGDAN

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Academic Medical Centers;Acceleration;adaptive immunity;Age;algorithm development;Algorithms;Antibodies;Autoimmunity;Awareness;Bronchiectasis;California;Caring;Case Report Form;Categories;Classification;Clinic;Clinical;clinical data repository;clinical data warehouse;Clinical Immunology;Code;collaborative approach;Common Variable Immunodeficiency;Computer Models;Computerized Medical Record;congenital immunodeficiency;cost;Data;Data Collection;Data Set;data sharing;data standards;data warehouse;Diagnosis;Diagnostic;Disease;disease diagnosis;disease phenotype;Drops;Electronic Health Record;Ethnic Origin;Evaluation;falls;Fibrosis;Future;Gender;Genes;Genetic;Genetic Diseases;genetic disorder diagnosis;genome sequencing;genomic data;Genomics;Goals;Health;Health Care Costs;health data;Health system;Healthcare Systems;Hospitals;Immune;Immune System Diseases;immunodeficiency;Immunogenetics;Immunological Diagnosis;Immunologics;Immunology;improved;Individual;Infection;Inflammation;innovation;Knowledge;Laboratories;Laboratory Research;life span;Link;Los Angeles;Lung;Machine Learning;Manuals;Medical;Medical center;medical specialties;Medicine;Mendelian disorder;Modeling;Morbidity - disease rate;mortality;Natural Immunity;neglect;next generation;Patients;peer;Phenotype;Predisposition;Prevalence;Process;Psychosocial Assessment and Care;Publishing;Quality of life;Race;Rare Diseases;Rare Immune Disease;Research;Risk;risk prediction;San Francisco;Schedule;Science;Scientist;screening;Site;Speed;State-of-the-Art Reviews;Structure;Subjects Selections;System;Testing;Thinking;Time;Training;transcriptome sequencing;Universities;video chat;Visit;whole genome;Work

PROJECT_TITLE: Collaborative multi-site project to speed the identification and management of rare genetic immune diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-N(52)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: Princeton

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Narrative/Health Relevance While many diverse mental health disorders share increased aggression as a common symptom, we lack a fundamental understanding of how neural circuits generate and maintain persistent high-aggression states. Since previous aggression experience is a robust predictor of future aggression in both humans and animal models, here, we will explore the neural mechanism by which aggression experience reshapes the output of a subcortical aggression control circuit. These data will lead to an integrated framework for understanding how experience facilitates behavior in both adaptive and pathological contexts, and will pave the way for new activity-based diagnostic tools to detect the neural effects of lived experience.

PI_NAMEs: FALKNER, ANNEGRET LEA (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adaptive Behaviors;Affective;Aggressive behavior;anatomical tracing;Animal Model;Animals;Architecture;Area;autism spectrum disorder;Behavior;Behavioral;Bipolar Disorder;Brain;Calcium;cell type;Classification;common symptom;Computing Methodologies;Control Locus;Data;density;Development;diagnostic tool;Doctor of Philosophy;Electrophysiology (science);experience;experimental study;Failure;Future;Generations;Goals;Health;Human;human model;Hypothalamic structure;In Vitro;in vivo;Individual;Intervention;lens;Life Experience;Lived experience;Maps;Measures;Mediating;Mental disorders;Methods;Modeling;Motivation;neural;neural circuit;neuromechanism;Neurons;novel;Optical Methods;Optics;optogenetics;Output;Pathologic;Pathology;Pathway interactions;patient population;Pharmaceutical Preparations;Physiologic pulse;Physiology;Population;Population Density;Population Dynamics;Populations at Risk;Post-Traumatic Stress Disorders;postsynaptic;presynaptic;Property;rabies viral tracing;Resolution;response;Rett Syndrome;Role;Route;Schizophrenia;sex;Shapes;Signal Transduction;Slice;social;Social Behavior;Source;Synapses;Target Populations;Testing;Time;tool;Traumatic Brain Injury;Update;Viral;Weight

PROJECT_TITLE: Mapping experience-dependent change in a circuit for aggression

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative (Overall) Rats are instrumental for the understanding of human disease and they play an important role in the development of drugs and therapeutics. The Rat Resource and Research Center provides a unique centralized repository for importing, storing and distributing a large number of rat strains, embryonic stem cells and related reagents. The RRRC also provides critical services to assist biomedical researchers and performs innovative research to ensure the quality, reproducibility and availability of rat models.

PI_NAMEs: BRYDA, ELIZABETH C (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Animal Model;Animals;Applied Research;Archives;Area;assay development;Behavioral;Biological Process;Biomedical Research;biomedical resource;Cardiovascular system;Communication;Communities;Consultations;cost;cost effective;COVID-19 pandemic;CRISPR/Cas technology;Cryopreservation;Cytogenetics;Derivation procedure;Disease;drug development;Embryo;embryonic stem cell;Ensure;ES Cell Line;Fee-for-Service Plans;Fertilization in Vitro;functional improvement;Gene Modified;Generations;Genetic;genetic analysis;Genetic Engineering;genome editing;Goals;Health;human disease;human model;improved;Individual;innovation;Institution;interest;Knock-out;Methods;microbiota;Mission;model development;model organism;Modeling;Modification;Monitor;mouse model;Mus;Physiology;Play;preservation;Process;Protocols documentation;Quality Control;rat genome;Rat Strains;Rattus;Reagent;repository;Reproducibility;Reproductive Biology;Research;Research Personnel;Resource Sharing;Resources;Rodent Model;Role;service delivery;Services;Spectral Karyotyping;sperm cell;sperm cryopreservation;Sperm Motility;Sperm Preservation;stem;Technology;Therapeutic;Time;Tissues;Toxicology;United States;United States National Institutes of Health;Vendor

PROJECT_TITLE: Rat Resource and Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-A(55)R]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PROJECT_TERMS: Animals;Archives;Biomedical Research;biomedical resource;Cell Line;Communication;Communities;Consultations;CRISPR/Cas technology;Cryopreservation;Derivation procedure;Embryo;embryonic stem cell;Ensure;ES Cell Line;experience;Fee-for-Service Plans;Funding;Gene Mutation;Generations;Genetic;genetic analysis;genome editing;Goals;Health;high standard;Human;human disease;Human Resources;improved;Individual;Infrastructure;interest;Investments;microbiota;model organism;Modeling;Modification;Monitor;Mutation;Pathology;preservation;Process;Protocols documentation;Quality Control;rat genome;Rat Strains;Rattus;Reagent;repository;Reproducibility;Reproduction;Research;Research Personnel;research study;Resource Sharing;Resources;service delivery;Services;sperm cell;Technology;United States National Institutes of Health;Vendor

PROJECT_TITLE: Resource

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-A]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: BIOLOGY

PHR: Project narrative These studies will use two-photon calcium imaging, single-cell photostimulation, and electrophysiology methods in vivo to investigate how hippocampal sharp-wave ripples and replay events shape and stabilize memory ensembles. Results from this proposed study will provide valuable insight on the population-wide and microcircuit mechanisms underlying long-term memory. By advancing our knowledge of the neural mechanisms of long-term memory in hippocampal networks, we can develop more effective treatments and interventions for memory- impaired clinical populations, such as patients of Alzheimer’s disease or dementia.

PI_NAMEs: DING, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease patient;Amnesia;awake;Behavior;Behavioral;Bilateral;Brain;Calcium;Cells;Chronic;Clinical;Code;Dementia;detection method;Development;Disease;effective intervention;effective therapy;Electrodes;Electrophysiology (science);Event;experience;experimental study;Foundations;Frequencies;High Frequency Oscillation;hippocampal pyramidal neuron;Hippocampus;Hour;Image;Impairment;improved;in vivo;in vivo calcium imaging;insight;Investigation;Knowledge;long term memory;Maps;Measures;Memory;memory consolidation;Memory Disorders;memory encoding;Memory impairment;memory process;memory recall;Methods;Nature;network architecture;neural;neuromechanism;novel therapeutics;Optics;optogenetics;Pathology;Patients;Pattern;Performance;Population;preservation;Process;Protocols documentation;recruit;Recurrence;Rest;Role;sensor;Shapes;Short-Term Memory;Sleep;spatial memory;Speed;Stable Populations;Structure;Task Performances;Techniques;Technology;Testing;Time;two-photon;virtual reality environment;Work

PROJECT_TITLE: Hippocampal Sharp-Wave Ripple and Replay Mechanisms Underlying Long-Term Memory

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ED_INST_TYPE: UNIVERSITY-WIDE

PHR: PROJECT NARRATIVE The auditory system is remarkably sensitive, capable of detecting air particle vibrations smaller than the diameter of a hydrogen atom, and prone to damage, as hearing loss affects over 48 million people in the US and over 1.5 billion people worldwide. This proposal aims to investigate the cellular mechanism that underly the sensitivity by measuring the motions of cells within the inner ears of living mice using modern optical coherence tomography and developing computational models of those motions using finite-element methods. Uncovering the details of these motions will reveal fundamental knowledge about the nature of hearing and has the potential to contribute to improved understanding, diagnoses, and treatment of human cochlear pathologies.

PI_NAMEs: ALBERTS, GABRIEL  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: 3-Dimensional;Affect;Air;Anatomy;Animals;Apical;Auditory system;Autopsy;base;Basilar Membrane;Binding;Biological;bone;capsule;cell motility;Cells;Characteristics;Cochlea;Computer Models;Data;Diagnosis;Diameter;Elements;Epithelium;External auditory canal;flexibility;Frequencies;Future;Gerbils;Hearing;hearing impairment;Human;Hydrogen;Image;Imaging technology;improved;in vivo;insight;Knowledge;Labyrinth;Length;Location;Measurement;Measures;Mechanics;Membrane;meter;Methods;microCT;Modeling;Modernization;mosaic;Motility;Motion;Mus;nanometer;nanoscale;Nature;normal hearing;novel imaging technology;Optical Coherence Tomography;Organ of Corti;Outer Hair Cells;Output;particle;Pathology;Persons;Phalanx;Phase;Physics;Pillar Cell;pressure;Process;Radial;Research;Resolution;response;Rest;round window;Sensory;Shapes;sound;Source;Stapes;Structure;Structure-Activity Relationship;System;Technology;tectorial membrane;Testing;three-dimensional modeling;Tissues;vibration;Wild Type Mouse

PROJECT_TITLE: Measuring and Modeling the Effects of Reticular Lamina Flexibility on Outer Hair Cell Bundle Phase and Cochlear Amplification


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE A fundamental, new mechanism has been identified that has relevance to Alzheimer’s disease (AD): somatic gene recombination in neurons that alters the Amyloid Precursor Protein gene. Key aspects of somatic gene recombination will be determined, including forms, functions, and enzymatic machinery. Neuropathological relationships and mechanistic studies will assess this new feature of the human brain for major forms of AD while identifying new AD therapeutic targets.

PI_NAMEs: CHUN, JEROLD  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Affect;aged;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Amyloid beta-Protein Precursor;Animal Experiments;Animal Model;Autopsy;Back;Biological Models;Brain;Brain region;brain tissue;Cell model;cell type;Complementary DNA;Copy Number Polymorphism;Data;Disease;DNA;DNA strand break;Down's Syndrome;ds-DNA;familial Alzheimer disease;FDA approved;Female;Foundations;Gene Proteins;Genes;Genetic Recombination;Genetic Transcription;genetic variant;Genome;Genomics;HIV;Human;human embryonic stem cell;IACUC;In Situ Hybridization;induced pluripotent stem cell;Institutional Review Boards;integration site;Knowledge;male;Methodology;Modeling;Molecular;Molecular Biology;Molecular Neurobiology;Molecular Target;mosaic;Mosaicism;nanobodies;Nature;neurobiological mechanism;Neurofibrillary Tangles;Neuroglia;Neurons;neuropathology;new therapeutic target;novel;Nucleotides;Pathogenicity;Patients;Pattern;Prevalence;Publishing;Reporting;Reverse Transcriptase Inhibitors;RNA;RNA-Directed DNA Polymerase;Role;Sampling;Senile Plaques;sequencing platform;sex;Testing;Therapeutic;therapeutic target;Toxic effect;Validation;Variant

PROJECT_TITLE: Altered reverse transcriptase-dependent gene diversification mechanisms in Alzheimer's disease brains

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]