ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Heart Disease;Lung;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Physical activity is an important modifiable behavior that has enormous impacts on the physical health and well-being of persons with chronic lung and heart disease. This online study examines an educational, motivational web platform coupled with a Fitbit step tracker and mind- body exercise classes that together teach mindful movement and support daily walking to help sustain physical activity in the long-term.

PI_NAMEs: YEH, GLORIA Y (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;Address;Adherence;Adverse event;adverse event risk;Anxiety;Area;Awareness;Behavior;behavior change;behavior measurement;Behavioral;behavioral construct;Breathing Exercises;Cardiac rehabilitation;Cardiopulmonary;Chronic;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Chronic pulmonary heart disease;clinical center;Cognitive;comorbidity;Congestive Heart Failure;Coupled;Coupling;curriculum enhancement;Data;Data Collection;Development;Disease;Disease Management;Dose;Dyspnea;Education;Educational process of instructing;efficacy evaluation;efficacy testing;efficacy trial;empowerment;Exercise;exercise capacity;exercise intervention;exercise intolerance;exercise program;experience;Fatigue;Feasibility Studies;fitbit;Fostering;Frequencies;Functional disorder;Funding;Goals;Grant;Habits;Health;Health behavior change;Health Promotion;health related quality of life;Heart Diseases;Heart failure;high risk;Home;Hospitalization;Hospitals;improved;improved outcome;individualized feedback;Instruction;interest;Internet;Intervention;Interview;intrinsic motivation;Literature;Logistics;Measures;Mediating;Mental Depression;Mind-Body Intervention;mind/body;mindfulness;modifiable behavior;Moods;Motivation;Movement;multi-component intervention;multimodality;Musculoskeletal;National Center for Complementary and Integrative Health;novel;novel strategies;online community;Online Systems;Outcome;Outpatients;patient oriented;Patients;pedometer;Personal Satisfaction;Persons;Physical activity;physical conditioning;Pilot Projects;Population;primary outcome;Procedures;programs;Pulmonary Heart Disease;pulmonary rehabilitation;Quality of life;recruit;remote delivery;Research;risk minimization;sedentary;sedentary lifestyle;Self Efficacy;Self-reflection;Social support;standard of care;success;symptomatology;Syndrome;Tai Ji;Technology;Theoretical model;Time;Transportation;Travel;treatment as usual;United States National Institutes of Health;Walking;wearable device;web platform;web-based intervention;Work

PROJECT_TITLE: Mindful Steps:  A Web-Based Mind-Body Exercise Intervention to Promote Physical Activity in Chronic Cardiopulmonary Disease


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Data Science;Dissemination and Implementation Research;Health Services;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Social Determinants of Health;Violence Research

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PI_NAMEs: ACRI, MARY C (contact)

PROJECT_TERMS: Adolescent;adverse outcome;Adverse reactions;Aggressive behavior;Area;Back;Caring;causal model;Child;Child Abuse;Child Abuse and Neglect;Clinical Trials;Collaborations;Complex;Data Science;Dedications;design;effective intervention;Etiology;Family;Family health status;field study;Funding;Goals;group intervention;Health;Hospitals;Impairment;implementation intervention;implementation science;improved;Incidence;insight;Intervention;Knowledge;Learning;maltreatment;member;Mental Depression;Modeling;neglect;Outcome;outreach;Performance;physical abuse;Post-Traumatic Stress Disorders;predictive modeling;prevent;Prevention;preventive intervention;primary care clinic;primary care clinician;primary care setting;Probability;Process;Randomized;Recommendation;Research;Research Project Grants;Resources;Risk;Risk Assessment;Risk Reduction;satisfaction;school based health center;screening;Self Destructive Behavior;Sexual abuse;Substance abuse problem;support tools;Technology;Testing;tool;tool development;Training;Translating;Translation Process;trustworthiness;Visit

PROJECT_TITLE: Research Project 2


NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Data Science;Pediatric;Prevention;Social Determinants of Health;Violence Research

PI_NAMEs: CLEEK, ANDREW  (contact)

PROJECT_TERMS: Administrator;Adolescent;Behavior;behavioral health;Biological;causal model;Child;Child Abuse and Neglect;Child Care;child services;Child Welfare;Clinical;clinical practice;Communication;Communities;Complex;Data Science;design;Development;Educational Curriculum;Educational Materials;Ensure;Ethics;Etiology;Event;experience;Family;Family member;field study;Goals;Incidence;Individual;Intervention;Knowledge;maltreatment;Manuals;marginalized community;meetings;Methods;Outcome;outreach;pediatrician;Policies;Policy Maker;Positioning Attribute;Poverty;predictive modeling;prevent;Prevention;Primary Care;Process;psychologic;Publications;Reporting;Research;Research Personnel;Resources;Risk;Role;Scientist;Series;Severities;support tools;System;Technology;Testing;tool;Training;Translating;trustworthiness;Work;Youth

PROJECT_TITLE: Dissemination and Outreach Core


ADMINISTERING_IC: MH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Transgender and gender diverse (TGD) young adults have a higher risk of suicide than cisgender young adults and suffer health disparities that are frequently compounded by race-based stigma and minority stress. This transformative multi-level intervention aims to advance equity and reduce health disparities for TGD young adults through individual, interpersonal, systemic, and community-based changes that increase knowledge and support among providers, young adults, and caregivers, thereby reducing suicidality and improving mental health.

PI_NAMEs: REISNER, SARI ;XU, RENA  (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Accounting;Address;Adolescent;Adolescent and Young Adult;Age;Anxiety;Area;arm;Birth;Black race;Caregiver support;Caregivers;Caring;Cause of Death;cisgender;Collaborations;Communication;Communities;Community of Practice;Consultations;Continuing Education;density;digital platform;digital solutions;Disparity;Dose;Education;Educational process of instructing;Effectiveness;effectiveness testing;effectiveness/implementation study;effectiveness/implementation trial;empowerment;Equity;Ethnic Origin;evidence base;Evidence based intervention;experience;experimental study;Face;Family;family support;Feeling suicidal;Focus Groups;Gender;gender affirming care;gender affirming therapy;gender diverse;Gender Identity;General Population;Health;health determinants;health disparity;health disparity populations;health equity;health inequalities;Health Services Accessibility;Healthcare;Heterogeneity;high risk;Hispanic;hormone therapy;Hour;implementation evaluation;Improve Access;improved;Individual;Inequity;innovation;insight;Intervention;Knowledge;Learning Module;Measures;Medical;Mental Health;Methods;minority stress;multiphase optimization strategy;National Institute of Child Health and Human Development;National Institute of Mental Health;National Institute on Minority Health and Health Disparities;Outcome;Participant;Pathway interactions;Patient Self-Report;Patients;peer;pilot test;Population;primary outcome;programs;Provider;provider networks;psychological distress;Psychosocial Assessment and Care;Public Health;Race;racial diversity;racial minority;Randomized;Recommendation;Reduce health disparities;reducing suicide;Reporting;Reproducibility;resilience factor;Resources;response;Risk;secondary outcome;sex assigned;simulation;social;social determinants;social health determinants;social stigma;Specialist;structural determinants;structural health determinants;suicidal;suicidal risk;Suicide;Suicide attempt;suicide rate;System;systemic intervention;Testing;Training;transgender;treatment as usual;treatment effect;United States National Institutes of Health;young adult;Youth

PROJECT_TITLE: TransHealthGUIDE: Transforming Health for Gender-Diverse Young Adults Using Interventions to Drive Equity


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Pediatric

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Anxiety is among the most common forms of psychopathology in youth, with symptom onset peaking in adolescence, and impairment extending across social, academic, and physical health domains. Over the past several decades, the social world of teens has been transformed by pervasive use of digital media (e.g., social media, messaging apps) but many open questions remain regarding links between online behavior and youth anxiety symptom development. Findings from this project will inform healthy technology use and provide evidence for potential treatment targets by identifying profiles of digital media use in daily life that predict anxiety trajectories, and by identifying mechanisms that explain why some youth may be more vulnerable to detrimental outcomes of digital media use.

PI_NAMEs: MYRUSKI, SARAH C (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: 18 year old;Address;Adolescence;Adolescent;Adult;Affect;Affective;Age;Anxiety;Anxiety Disorders;anxiety symptoms;Arousal;Attention;attentional bias;Behavior;biobehavior;Biological;childhood anxiety;clinically significant;Cognitive;cognitive control;cognitive system;Communication;Communication difficulty;Compensation;Computers;Coupled;COVID-19 pandemic;critical period;Data;design;Development;Devices;digital media;digital technology;Ecological momentary assessment;Electroencephalography;emotion regulation;emotional experience;Emotions;Environment;experience;Face;Female;flexibility;Fostering;Frequencies;Habits;handheld mobile device;Health;Impairment;indexing;Individual Differences;infancy;innovation;Instagram;Interview;Investigation;Life;Link;Literature;longitudinal design;male;Measurement;Measures;media use;Mediating;Mental Health;Methodology;Methods;National Institute of Mental Health;negative affect;Negative Valence;Neurocognitive;neurodevelopment;Outcome;Participant;Patient Self-Report;Pattern;Perception;Persons;physical conditioning;Physiology;preference;Prevalence;Process;Psychopathology;Psychophysiology;Questionnaires;Reaction Time;Recommendation;recruit;Reporting;Research;Research Domain Criteria;Rest;Risk;Role;rumination;Sampling;Sex Differences;showing emotion;social;Social Behavior;Social Change;social media;Social Processes;Strategic Planning;Symptoms;Technology;Teenagers;Time;United States National Institutes of Health;Variant;visual tracking;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Investigation of Digital Media Use, Anxiety, and Biobehavioral Emotion Regulation in Adolescents


NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: HADLEY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: This study proposes to develop a novel multi-modal sensing platform to monitor stroke survivors’  upper-limb performance in their naturalistic environments. The outcomes of the proposed research project  could impact nearly 800,000 Americans undergoing stroke rehabilitation each year—more broadly,  patients suffering from hemipareses, such as traumatic brain injuries and multiple sclerosis—by enabling  personalized rehabilitation programs focusing on motor performance.

PI_NAMEs: LEE, SUNGHOON  (contact);STOYKOV, MARY ELLEN

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Accelerometer;Adult;American;Augmented Reality;Behavior;Brachial Paresis;Clinic;Clinical;clinical investigation;Communication;Communities;community setting;Data;disability;Elements;Engineering;Environment;experimental study;Goals;hemiparesis;Home;Human;Human body;human-robot interaction;Impairment;improved;Informatics;instrument;kinematics;Kinetics;Laboratories;machine learning algorithm;machine learning model;Measurement;Measures;Monitor;Motor;Movement;multimodal data;multimodality;Multiple Sclerosis;novel;Outcome;Patient Monitoring;Patients;Pattern;Performance;post stroke;pressure sensor;Process;programs;radio frequency;Reader;Recovery;rehabilitation science;Rehabilitation therapy;Research;Research Project Grants;sensor technology;Series;Signal Transduction;smart home;Stroke;stroke rehabilitation;stroke survivor;System;Tactile;Taxonomy;Technology;Time;tool;Translating;Traumatic Brain Injury;Upper Extremity;Upper limb movement;Work;Wrist;wrist worn device

PROJECT_TITLE: SCH: A Sensing Platform Monitoring Interactions with Daily Objects to Assess Real-World Motor Performance in Stroke Survivors


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BETHESDA

ORG_NAME: PARENTERAL DRUG ASSOCIATION, INC.

ORG_STATE: MD

PHR: These trainings help outsourcing facilities and other stakeholders increase technical capabilities and improve facility operations, by gaining an overview of FDA regulatory framework for compounding, identifying insanitary conditions in their facilities, and implementing appropriate corrective actions. Protecting patients from poor-quality compounded drugs is a shared responsibility among the FDA, outsourcing facilities, compounders, state regulators and other stakeholders.

PI_NAMEs: PORTER, MIKE  (contact)

PROGRAM_OFFICER_NAME: HAMMOND, JILL

PROJECT_TITLE: Education and Training Program for Outsourcing Facility Industry


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury;Urologic Diseases

ORG_CITY: LOUISVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Spinal cord epidural stimulation, which creates an electrical field directly over the spinal cord, has shown early promise with clinical effectiveness for restoration of voluntary and reflex control of the lower urinary tract. The goal of this pre-clinical research is to optimize epidural stimulation alone and in combination with neurorehabilitation for functional urological benefits and identify mechanism(s) to better facilitate daily management and improve quality of life for those with spinal cord injuries.

PI_NAMEs: HUBSCHER, CHARLES H. (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acute;Address;Aftercare;Anesthesia procedures;Ataxia;Bilateral;Biological Markers;Bladder;Bladder Tissue;Cell Nucleus;Cells;chemokine;cholinergic;Chronic;Clinical effectiveness;Clinical Trials;clinically relevant;Commissure;Contusions;design;Development;Devices;Dorsal;dorsal horn;Effectiveness;electric field;Electrodes;experimental study;FOS Protein;Functional disorder;functional outcomes;Goals;gray matter;Health;Health Care Costs;Histology;Hour;Human;Immune;improved;Individual;Induced Neurons;Location;Locomotor training;Lower urinary tract;Maintenance;Maps;Mediating;Modeling;Molecular Biology;Motor;multi-electrode arrays;Nerve;nerve transection;neural;neurological rehabilitation;Neurons;neuroregulation;novel;Outcome;Pattern;Pelvis;Peripheral;peripheral nerve transection;postsynaptic;pre-clinical research;preclinical study;pressure;Quality of life;Rattus;Recommendation;Reflex action;Reflex control;Rehabilitation therapy;response;response to injury;restoration;Source;Sphincter;Spinal;Spinal Cord;Spinal cord injury;Spinal Cord Tract;Structure;Synapses;System;Technology;timeline;Training;treadmill;Urethane;Urinary tract;urologic

PROJECT_TITLE: Targeting urinary tract dysfunctions after spinal cord injury with epidural stimulation

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Borderline personality disorder (BPD) is a serious mental illness associated with comorbidity across internalizing and externalizing pathology as well as high personal and societal cost. This study will use a high-risk design to assess problematic interpersonal behavior exhibited by children with their friends to determine whether it reflects a precursor to BPD or other internalizing and externalizing problems. Results will provide critical information about hypothesized disease trajectory for BPD, which will inform targets for prevention and early intervention.

PI_NAMEs: VANWOERDEN, SALOME  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Accounting;Address;Adolescence;Affective;Age;Arousal;Behavior;behavior observation;Behavioral;Borderline Personality Disorder;Child;Child Rearing;Childhood;Clinical;comorbidity;Conflict (Psychology);Control Groups;cost;Cues;Data Analyses;Depressed mood;design;Development;Disease;dynamic system;Early identification;Early Intervention;emotion dysregulation;Emotional;Etiology;Exhibits;experience;Family;Female;follow-up;Fostering;Friends;Friendships;Functional disorder;Gender;Genetic;Goals;high risk;human old age (65+);Hypersensitivity;in vivo;insight;Institution;intergenerational;intimate behavior;Life;Maternal Age;Measurement;Measures;Mental Depression;Mental disorders;Mentors;Methods;middle childhood;Modeling;Mother-Child Relations;Mothers;multimodality;National Institute of Mental Health;offspring;Parent-Child Relations;Parents;Pathology;Patient Self-Report;Pattern;peer;Personality;Personality Traits;Phase;Phenotype;Physiological;Prevention;preventive intervention;Process;programs;Psychiatry;Psychologist;Psychopathology;Psychophysiology;Public Health;Questionnaires;Race;Reporting;Research;Research Design;Research Personnel;Research Support;response;Risk;satisfaction;severe mental illness;social;societal costs;sociodemographic factors;Specificity;Strategic Planning;symptomatology;Systems Theory;teacher;Testing;Time;Training;transmission process;Universities;Work;Youth

PROJECT_TITLE: Dysfunctional behavior with friends during middle childhood as a precursor to borderline personality pathology

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE E-cigarette use has increased steadily among US adolescents during the past decade, in part due to the availability of e-liquids in youth-appealing flavors. Conversely, e-cigarettes have also emerged a potentially reduced harm product for adults who smoke and are unwilling or unable to stop using nicotine. Using the Population Assessment of Tobacco or Health (PATH) Survey, a nationally-representative, annual cohort study of adolescents and adults, we will investigate mechanisms by which statewide flavored e-cigarette bans affect e-cigarette and other tobacco product use (risks) as well as smoking cessation or reduction (benefits).

PI_NAMEs: DENLINGER-APTE, RACHEL ;LIN, MENG-YUN  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Adolescent;Adolescent and Young Adult;Adult;Affect;Age;age group;authority;Behavior;Behavioral;Benefits and Risks;Biological Markers;Candy;Cigarette;Cigarette Smoker;cigarette smoking;Clinical Trials;Cohort Studies;combustible tobacco;Consumption;Counseling;Data;Data Set;design;Devices;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Event;Frequencies;Fruit;Goals;Harm Reduction;Health Policy;Health Surveys;High School Student;Individual;interest;Manufacturer;Menthol;Middle School Student;Natural experiment;Nature;Nicotine;Nicotine Dependence;nicotine replacement;nicotine use;Participant;Pattern;Policies;Population;Population Assessment of Tobacco and Health;prevent;Public Health;Quasi-experiment;Regulation;Reporting;Research Personnel;Risk;Sales;Science Policy;skills;Smoke;Smoker;Smoking;Smoking Behavior;smoking cessation;success;Tobacco;tobacco flavor;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;tool;United States Food and Drug Administration;vaping;young adult;Youth

PROJECT_TITLE: The effects of flavored e-cigarette sales bans on tobacco-use behaviors among youth and adults


ADMINISTERING_IC: CA

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: GENETICS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE Our studies focus on developing new and more effective immunotherapy strategies for treating cancer. The proposed research will define pathways contributing to immune response within the tumor microenvironment and test these findings using newly developed pre-clinical models. This work has the potential to significantly advance cancer treatment by developing new treatment methods and by increasing the overall knowledge of the biology of antibodies in the treatment of cancer.

PI_NAMEs: RAVETCH, JEFFREY VICTOR (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Advanced Malignant Neoplasm;Antibodies;Antibody Therapy;Biology;cancer therapy;cancer vaccination;Clinical;Clinical Trials;Engineering;Funding;Generations;Goals;Immune response;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;Knowledge;long term memory;Malignant Neoplasms;Mediating;Memory;Methods;Molecular;Monoclonal Antibodies;neoplasm immunotherapy;Pathway interactions;Pre-Clinical Model;Recurrence;Research;response;Testing;Therapeutic;Therapeutic Effect;therapy development;tumor;Tumor Antibodies;tumor microenvironment;Work

PROJECT_TITLE: Molecular mechanisms of antibody-mediated immunotherapies


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Health Services

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE Our population is aging, which raises many important questions regarding how to deliver optimal care for the growing number of older adults who are frail or have complex health needs such as multiple co-existing conditions or loss of independence. We propose an innovative, interdisciplinary training program to produce the next generation of researchers with robust training in person and family-centered health services and outcomes research, all applied to geriatrics and gerontology. Our program will provide training in the methods to understand how health services, delivery of health care, and financing systems might optimally be designed to serve the needs of older adults.

PI_NAMEs: BOYD, CYNTHIA MELINDA;WOLFF, JENNIFER L. (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Aging;Health Services Research;Outcomes Research;Population

PROJECT_TITLE: Health Services and Outcomes Research for Aging Populations


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE We aim to circumvent the current challenges of islet transplantation to boost therapeutic efficacy and achieve longterm treatment of Type 1 diabetes. Through harnessing principles of engineering, immune-isolation, and gene editing and chemical biology, we aim to demonstrate in vivo enhanced survival of islet grafts, reduced fibrosis, and prolonged glycemic control. PHS 398/2590 (Rev. 06/09) 1 Continuation Format Page

PI_NAMEs: CHOUDHARY, AMIT  (contact);DEVARAJ, NEAL KRISHNA;KARP, JEFFREY MICHAEL;KULKARNI, ROHIT N.

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Affinity;Anti-Inflammatory Agents;Benchmarking;Beta Cell;Binding;Biology;Cadaver;Cell Culture Techniques;Cell Line;Cell Membrane Permeability;Cell Physiology;Cell Proliferation;Cell secretion;Cell Survival;Cell Transplantation;cell type;Cells;chemical conjugate;Chemicals;Clinical Trials;cost;cost effective;CRISPR/Cas technology;cytokine;Dependence;Development;differentiation protocol;Dyes;elastase inhibitor;embryonic stem cell;Encapsulated;Endocrine;engineered beta cell;Engineering;Exhibits;Face;Fibrosis;fluorophore;Foreign-Body Reaction;Generations;Genes;Genetic;genome editing;Genome engineering;Glucose;glycemic control;Graft Rejection;Harmine;Human;Immune;Immune system;immunoregulation;Immunosuppressive Agents;Impairment;implantation;in vivo;induced pluripotent stem cell;inhibitor;Insulin;Insulin-Dependent Diabetes Mellitus;Interleukin-10;Ions;islet;Islets of Langerhans;Islets of Langerhans Transplantation;Knock-in;large scale production;Legal patent;Libraries;Life;Ligands;Mitogens;mouse model;Pancreas;Patients;Plasma;Population;precise genome editing;Prevention;Procedures;Prodrugs;Production;Proliferating;Property;Protein Tyrosine Kinase;Protocols documentation;Quality of life;Replacement Therapy;Reporting;Scheme;side effect;small molecule;Sorting;Source;Specificity;stem cells;Surgical Replantation;System;Teratoma;Therapeutic;therapeutic development;Therapeutic Effect;Time;Transplantation;transplantation therapy;Treatment Cost;Treatment Efficacy;Undifferentiated;United States National Institutes of Health;Validation;Zinc

PROJECT_TITLE: Development of platforms for sorting, production, editing of beta cells

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Janice M. Mehnert, M.D., Professor of Medicine, serves as the Associate Director for Clinical Research and Director, Melanoma and Cutaneous Medical Oncology at the Perlmutter Cancer Center (PCC) of NYU Langone Health/NYU Grossman School of Medicine, and in these roles devotes significant effort toward the promotion of NCI sponsored clinical research. She demonstrates a track record of funding, publications, and mentorship, and has launched several new initiatives to improve the process and innovation of clinical research at PCC. In this application, she outlines plans to support PCC faculty to lead NCI sponsored trials, to enhance accrual to these trials, to improve research processes for trial screening and accrual, and to promote diversity, equity, and inclusion in PCC’s clinical research efforts.

PI_NAMEs: MEHNERT, JANICE M. (contact)

PROGRAM_OFFICER_NAME: MAHER, MOLLY ELIZABETH

PROJECT_TERMS: American College of Radiology Imaging Network;Award;Cancer Center;Clinical Cancer Center;Clinical Research;Clinical Trials;Clinical Trials Network;Communication;Cutaneous;Disease Management;Doctor of Medicine;Early Therapeutic-Clinical Trials Network;Eastern Cooperative Oncology Group;Equity;equity, diversity, and inclusion;ethnic diversity;Faculty;Funding;Future;Goals;Grant;Health;Hospitals;improved;Information Technology;Infrastructure;innovation;Lead;Long Island;Medical Oncology;medical schools;Medicine;Melanoma;Mentors;Mentorship;Mission;National Clinical Trials Network;NCI Center for Cancer Research;Oncology;operation;Organizational Affiliation;patient oriented;Patients;phase I trial;Physician Executives;Population Programs;Precision medicine trial;Process;process improvement;professor;Protocols documentation;Publications;Publishing;racial diversity;recruit;Research;Research Activity;Research Infrastructure;Research Personnel;Resource Allocation;Resources;Rewards;Role;Scientist;screening;Site;Skin;Specialist;Strategic Planning;Supervision;targeted cancer therapy;Time;timeline;Underserved Population

PROJECT_TITLE: Promoting a Culture Of Innovation, Mentorship, Diversity and Opportunity in NCI Sponsored Clinical Research: NCI Research Specialist (Clinician Scientist) Award Application of Janice M. Mehnert, M.D.


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Pediatric;Pediatric - AIDS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative Children with HIV-1 who have been on antiretroviral treatment (ART) since birth are an ideal population to benefit from new and potentially curative strategies for treating HIV-1. This study will extend findings from the Tatelo Study, where 44% of children succeeded on dual treatment with broadly neutralizing antibodies (bNABs), by providing three broad and potent long-acting bNAbs to selected children as an alternate treatment strategy that may be as effective as ART. Participants with the greatest potential to achieve post-treatment control of HIV-1 will then be offered an analytic treatment interruption (ATI) with close clinical monitoring.

PI_NAMEs: KURITZKES, DANIEL R.;LICHTERFELD, MATHIAS ;SHAPIRO, ROGER L (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: adaptive immune response;Adherence;Adolescent;Adult;Aftercare;antibody immunotherapy;Antibody Therapy;antiretroviral therapy;appropriate dose;Biological Assay;Birth;Botswana;CD4 Lymphocyte Count;Characteristics;Child;Child Development;Childhood;Clinical;Clinical Markers;Clinical Trials;cohort;critical period;Data;design;DNA;Dose;Drug Kinetics;Ensure;follow-up;Genome;Growth and Development function;HIV;HIV serology;HIV Seronegativity;HIV-1;Immune response;Immunotherapy;improved;Infection;Innate Immune Response;innovation;Interruption;Intervention;Maintenance;Measures;Monitor;Morbidity - disease rate;mortality;neutralizing antibody;novel;novel strategies;Outcome;Outcome Study;Participant;Pattern;pediatric human immunodeficiency virus;Pediatrics;Population;preservation;Protocols documentation;Research;Residual state;RNA;Rotation;Safety;Serology test;small molecule;Specific qualifier value;success;Testing;Time;Training;treatment response;treatment strategy;Treatment-related toxicity;Use Effectiveness;Vaccines;Viral;Viral reservoir;Visit

PROJECT_TITLE: A Clinical Trial of Three Broadly Neutralizing Antibodies and Analytic Treatment Interruption in Early-Treated Children in Botswana


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Bacterial lipoproteins are structures located on the surface of all bacteria that are critical to bacterial fitness and their potential to cause infections. Lipoproteins are detected by components of the immune system responsible for mounting a response to clear the infection. This project aims to understand how bacteria make their lipoproteins and why they change the structure of their lipoproteins, a process that ultimately impacts the ability of immune system to detect and respond to bacteria.

PI_NAMEs: MEREDITH, TIMOTHY C. (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Acetates;Acetyl Coenzyme A;Acetylation;Acylation;Address;Adhesions;Amino Acids;Attenuated;attenuation;Bacillus cereus;Bacillus subtilis;Bacteria;bacterial fitness;Bacterial Proteins;Binding;Biochemical;Biochemistry;Biological Assay;Carbohydrates;cell envelope;cell growth;Cell surface;cell type;Cells;chemokine;Chromosomes;Complex;Copper;Cysteine;cytokine;Cytosol;detection platform;Drug Metabolic Detoxication;Enterococcus faecalis;Environment;Enzymes;Event;extracellular;Family;Fatty Acids;Firmicutes;fitness;gene network;Gene Transfer;Genes;Genetic;Genome;Genus staphylococcus;Germination;Goals;Gram-Negative Bacteria;Growth;Humoral Immunities;Immune system;In Vitro;Infection;Inflammatory;Innate Immune System;Ions;Knock-out;Label;Length;Ligands;Lipase;Lipoprotein (a);Lipoprotein Binding;Lipoproteins;Maps;Measures;Medical;member;Membrane;Membrane Proteins;microbial;Modeling;Modification;Mutation;N acylation;N-terminal;Names;Natural Immunity;Nutrient;Orthologous Gene;oxidation;oxidative damage;Pathogenicity;Pathway interactions;Pattern;Phenotype;Physiological;Physiology;Plasmids;Play;Polyunsaturated Fatty Acids;Positioning Attribute;pressure;prevent;Process;protein complex;protein protein interaction;Protein Secretion;Proteins;Reaction;receptor;Recombinants;reconstitution;Reproduction spores;resistance gene;response;Role;Signal Transduction;Source;Staphylococcus aureus;Structure;Surface;System;Testing;TLR2 gene;Transacylase;Transferase;transposon sequencing;Variant;Virulence Factors

PROJECT_TITLE: N-terminal acylation of Lipoproteins in Firmicutes

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: In this proposal, which is written in response to the MorPhic consortium, our center will create a barcoded, chemically inducible, and reversible system to deplete protein of interest. To achieve this, we utilize a sensitive auxin-inducible degron (AID) to degrade the target proteins with a small chemical molecule rapidly. We will create this unique null allele generation resource for 250 critical genes in human induced pluripotent cell. The obtained information will demonstrate the feasibility of this strategy for the ultimate goal of the MorPhic. It will reveal the biological roles of a large number of developmentally critical genes that are not amenable to chronic deletion.

PI_NAMEs: ADLI, MAZHAR  (contact);BURRIDGE, PAUL W.;YUE, FENG

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Acute;Alleles;Auxins;Bar Codes;Biological;Biological Process;Cardiac Myocytes;Cardiovascular Diseases;Catalogs;Cell Death;Cell Differentiation process;Cell Line;Cell Lineage;Cell membrane;cell type;Cells;Chemicals;Chromatin;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Cods;conditional knockout;Data;Defect;Development;Disease;Dose;embryonic stem cell;Encyclopedia of DNA Elements;Engineering;Essential Genes;fitness;Foundations;Gene Expression;Generations;Genes;Genetic;genetic approach;genetic manipulation;Germ Layers;Goals;Human;Human Development;human disease;Human Genome;Human Genome Project;human induced pluripotent stem cells;human model;In Vitro;induced pluripotent stem cell;insight;interest;International;knock-down;Knock-in;Knock-out;knockout gene;Knowledge;live cell imaging;Location;Mediating;Methods;Mitotic;Modeling;Molecular;molecular phenotype;Mus;Organoids;Phase;Phenotype;Plant Growth Regulators;pluripotency;Pluripotent Stem Cells;Process;Production;Proliferating;Proteins;research and development;Resources;response;Role;scale up;screening;Small Interfering RNA;stem;System;Western Blotting;Writing

PROJECT_TITLE: Molecular and cellular characterization of essential human genes.


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE Patients with advanced pancreatic ductal adenocarcinoma desperately need novel and effective therapeutics. Macrophage allotransplantation seems permissive, making them a safe choice as a “third-party, off-the-shelf” cell therapy option. The proposed research will not only provide a proof-of-concept regarding the combination therapy of KRAS inhibitors and macrophages genetically engineered with chimeric antigen receptors and pro- inflammatory cytokines, but will also enhance the understanding of macrophage self-renewal, plasticity, signaling transduction and function execution.

PI_NAMEs: HOU, PINGPING  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Address;Adjuvant Therapy;Adverse effects;allotransplant;anti-tumor immune response;Antigens;Ascites;Biological Assay;Biology;Cancer Etiology;Cancer Model;CD147 antigen;CD47 gene;Cell Culture Techniques;Cell Therapy;Cells;cellular engineering;Cessation of life;Chemicals;chimeric antigen receptor;clinical application;clinical risk;Clinical Trials;Collaborations;Colon Carcinoma;Combined Modality Therapy;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;cytokine;cytokine therapy;cytotoxic;cytotoxicity;Data;design;disorder control;Engineering;Enhancers;Ensure;experience;Gene Expression;Genes;Genetic;Genetic Engineering;Genetic Transcription;Goals;Growth;Hematopoietic stem cells;Homing;Homologous Transplantation;Human;human disease;Hypoxia;Immune;Immune response;Immunity;Immunologist;Immunophenotyping;Impairment;In Vitro;in vivo;Inflammatory;inhibitor;Intravenous;Knowledge;KRAS2 gene;Liver;Lung;Macrophage;Maintenance;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Methods;mouse model;MSLN gene;Mus;mutant;neoantigens;Neoplasm Metastasis;novel;Oncogenic;Organ;Outcome;Oxygen;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic tumorigenesis;Pathway interactions;Patients;permissiveness;Phagocytosis;Physiological;pre-clinical;Pre-Clinical Model;Primary Neoplasm;programs;Proliferating;promoter;PTPNS1 gene;Receptor Activation;Recurrence;Recurrent tumor;Research;Resistance;Risk;Role;RXR;Safety;screening;self-renewal;Signal Transduction;single cell sequencing;single-cell RNA sequencing;SIRT1 gene;Solid Neoplasm;Spleen;suicide gene;synergism;System;systemic toxicity;targeted treatment;Tertiary Protein Structure;Therapeutic;therapeutically effective;Tissues;Toxic effect;transgene expression;Transplantation;tumor;tumor growth;tumor microenvironment;Tumor-associated macrophages;United States

PROJECT_TITLE: Develop Conditionally Armored CAR Macrophage Therapy for Pancreatic Cancer

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Bioengineering;Diabetes

ORG_CITY: OREGON CITY

ORG_NAME: HEMINGWAY DESIGNS, LLC

ORG_STATE: OR

PHR: While lancets are an indispensable part of diabetes self-management, their safe disposal has been problematic since the beginning of their widespread use. With better understanding of the impact of plastic waste on the environment, there is growing awareness that lancets are a significant source of single-use plastic. Hemingway Designs is developing an innovative lancet constructed from novel materials that provides users safe, convenient disposal without generating any plastic waste.

PI_NAMEs: BRANDELL, BRIAN  (contact)

PROJECT_TERMS: Address;Adherence;Alloys;Awareness;base;Benchmarking;biomaterial compatibility;Blood Glucose Self-Monitoring;Caregivers;Characteristics;Classification;commercialization;Communities;Compost;Corrosion;cost;design;Development;Device or Instrument Development;Devices;Diabetes Mellitus;diabetes self-management;Dimensions;Economics;Education;Engineering;Environment;expectation;fabrication;facsimile;Finite Element Analysis;flexibility;Formulation;Future;hazard;Home;Household;improved;inclusion criteria;innovation;landfill;Legal;light weight;Magnesium;manufacturability;Manufacturer;Marketing;mechanical properties;Medical Device;member;Metals;Methods;Modeling;Molds;Monitor;Nanostructures;National Institute of Diabetes and Digestive and Kidney Diseases;Needles;Notification;novel;Outcome;Performance;performance tests;Phase;Polishes;Polymers;preconditioning;Preparation;Procedures;Process;product development;programs;prototype;Regulation;Research;research clinical testing;Research Proposals;Safety;Sanitation;Sharps Injury;Small Business Innovation Research Grant;Source;Specific qualifier value;Sterilization;System;Techniques;Technology;Testing;User Compliance;Vinegar;wasting

PROJECT_TITLE: Lancet with dissolvable blade and biodegradable base

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (10)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Kidney Disease;Liver Disease;Orphan Drug;Rare Diseases;Substance Misuse

ORG_CITY: PALO ALTO

ORG_NAME: MITOPOWER LLC

ORG_STATE: CA

PHR: Narrative  Alcoholic liver disease is the major cause of hepatorenal syndrome with acute kidney injury (HRS-AKI). HRS- AKI is a progressive condition, leading to kidney failure, and associated with mortality rates reaching 50%, with many patients requiring hemodialysis and/or liver transplant. MitoPower is developing a small molecule therapeutic with the ability to enhance cellular metabolism and improve outcomes in animal models of AKI. With funding, we will complete the studies required for FDA approval and conduct the first clinical testing of this novel therapeutic.

PI_NAMEs: KOTTILIL, SHYAMASUNDARAN ;SUBRAMANIAN, MANI  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;acute toxicity;Address;aging related disease;Alcoholic Liver Diseases;Alcohols;Animal Model;Biogenesis;Canis familiaris;Cell Physiology;Clinical;Death Rate;Development;dihydronicotinamide;DNA Damage;Dose;first-in-human;Formulation;Functional disorder;Funding;Gene Expression;genotoxicity;Goals;hallmarks of aging;healthy volunteer;Hemodialysis;Hepatic;Hepatocyte;Hepatorenal Syndrome;Histology;Hospitalization;Human;human study;Immune;Immunomodulators;Impairment;improved;improved outcome;In Vitro;in vivo;Inflammatory;Injury to Kidney;Intravenous;ischemic injury;Kidney;Kidney Failure;lipid biosynthesis;Liver;Liver Cirrhosis;Liver diseases;liver injury;liver transplantation;manufacture;Mediating;Metabolism;Mitochondria;mitochondrial dysfunction;Nicotinamide adenine dinucleotide;nicotinamide-beta-riboside;novel therapeutics;Organ failure;Outcome;oxidation;Oxidative Stress;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Pharmacology and Toxicology;Phase;Phase I Clinical Trials;Population;Preparation;prevent;Process;Rattus;Renal function;research clinical testing;riboside;Role;Safety;Serum;Small Business Innovation Research Grant;small molecule therapeutics;standard of care;Supplementation;systemic inflammatory response;Therapeutic;Therapeutic Index;Time;tissue culture;Tissues;Toxic effect;Whole Blood;Work

PROJECT_TITLE: Novel therapy for alcoholic liver disease-associated hepatorenal syndrome


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Pediatric

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE This longitudinal research elucidates why some children embark on positive paths toward competent, prosocial, rule-abiding, productive lives with robust socioemotional growth, whereas others enter paths toward poor competence; disregard for conduct rules and others’ welfare; callous, disruptive, and high-risk behaviors; and impoverished socioemotional growth. We study powerful, complex long-term effects of early parent–child relationships, formed in the first years of life and interwoven with the child’s biological individuality, as key to understanding why and how such diverse paths originate in infancy and early childhood. Overall, this research embraces key public health goals by producing evidence-based, fundamental basic knowledge, which can then inform effective parenting intervention and prevention programs that enhance socioemotional growth for our nation’s children and reduce the profound burdens for children, families, and society that can be caused by negative, disruptive developmental trajectories.

PI_NAMEs: KOCHANSKA, GRAZYNA  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Adult;Advocate;Age;Anger;antisocial behavior;Assertiveness;Behavior;Biological;callous unemotional trait;catalyst;Child;Child Behavior;cognitive skill;Communities;Competence;Complex;COVID-19;Data;Data Set;Development;dynamic system;early childhood;Ecology;Emotional;Equation;evidence base;expectation;experience;Family;Family dynamics;Fathers;Feeling;follow-up;Funding;Future;Genetic;Goals;Growth;health goals;high risk;high risk behavior;Individuality;infancy;Infant;Influentials;information processing;innovation;intervention program;kindergarten;Knowledge;Life;Link;Long-Term Effects;Measurable;Measures;Mediation;Methods;middle childhood;Mind;Modeling;Mothers;Motion;Outcome;Parent-Child Relations;parenting intervention;Parents;Pathway interactions;Perception;person centered;Personality;Poverty;preservation;prevent;Prevention program;Problem behavior;Process;Productivity;Psychopathology;Public Health;Recording of previous events;Reporting;Research;Risk;Role;Rules of conduct;Schools;Science;Secure;social;social cognition;social skills;Socialization;Societies;Source;System;Temperament;Testing;theory of mind;Time;Trust;United States National Institutes of Health;Vision;welfare;Work

PROJECT_TITLE: Elucidating the legacy of early parent-child relationship: A new developmental synthesis of temperament, internal representation, and behavior

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Neurosciences;Physical Activity;Postural Orthostatic Tachycardia Syndrome;Prevention

ORG_CITY: DALLAS

ORG_DEPT: NEUROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative This project aims to improve our understanding of postural orthostatic tachycardia syndrome (POTS) by comprehensively studying of a large group of patients. This will allow us to better understand the different types of POTS patients and lead to more individualized treatment approaches.

PI_NAMEs: LEVINE, BENJAMIN D;VERNINO, STEVEN A (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Acute;Affect;Agreement;American;Ancillary Study;Biochemical;Biological;Biological Specimen Banks;Blood specimen;Blood Tests;Blood Volume;Cardiac;Characteristics;Chronic;Chronic Disease;Classification;Clinical;clinical database;clinical phenotype;clinically relevant;Cluster Analysis;cohort;Collaborations;comparative;Complex;conditioning;Data;Data Set;Derivation procedure;design;Diagnostic;diagnostic tool;disabling disease;disabling symptom;Evaluation;Exercise;exercise intensity;exercise intolerance;exercise program;Exercise Test;exercise training;falls;fitness;follow-up;Funding;Future;Gases;Genomics;Goals;Health;Heart;hemodynamics;Immune system;Immunologic Markers;Immunophenotyping;Impairment;improved;Individual;individualized medicine;innovation;Investigation;Laboratories;Measures;Metabolism;metabolomics;Modality;Modification;Molecular;Monitor;Morbidity - disease rate;multimodal data;multimodality;Muscle;Normal Range;novel;novel therapeutics;orthostatic intolerance;Outcome;Outcome Measure;Participant;Patients;Phenotype;Physical activity;Physiological;Postural Orthostatic Tachycardia Syndrome;predicting response;Procedures;productivity loss;prognostic value;programs;Proteomics;Protocols documentation;Publishing;Quality of life;recruit;Regulation;Reporting;Research;Research Personnel;research study;Resolution;response;Skeletal Muscle;standard of care;Structure;Symptoms;Syndrome;Testing;Therapeutic;Training;Transducers;United States National Institutes of Health

PROJECT_TITLE: Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: Durban

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: CENTRE/AIDS PROGRAMME/RES/SOUTH AFRICA

PHR: Project Narrative In South Africa, cervical cancer prevention remains suboptimal in regions such as KwaZulu- Natal province which has a dual burden of high Human Immunodeficiency Virus (HIV) incidence and high cervical cancer incidence. Participation in clinical trials undertaken through the CASCADE Clinical Trials Network will provide an opportunity to advance and support existing cervical cancer prevention programs in this setting. Through the network, we aim to improve on cervical cancer screening strategies and to evaluate novel treatments and interventions for women with premalignant lesions of the cervix, with a view to improve clinical outcomes and to reduce the burden on the health care system.

PI_NAMEs: NAICKER, NIVASHNEE  (contact)

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: ablative procedure;Acceleration;Acquired Immunodeficiency Syndrome;African;Aftercare;Age;aged;AIDS prevention;antenatal;antiretroviral therapy;Area;base;Businesses;cancer diagnosis;Cancer Etiology;CD4 Lymphocyte Count;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervical Smears;Cervix Uteri;Clinical;Clinical Management;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;clinically relevant;clinically significant;co-infection;cohort;Collaborations;Colposcopy;Communities;COVID-19;Cytology;Data;data management;Diagnostic;Disease;Educational Status;Epidemic;epidemic virus;Epidemiology;epidemiology study;Evaluation;experience;Feasibility Studies;Female;follow-up;Funding;Goals;Health Services Accessibility;Healthcare Systems;High Prevalence;HIV;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;Household;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papillomavirus;Improve Access;improved;Incidence;Infection;Infrastructure;insight;International;Intervention;Laboratories;Leadership;Lesion;Malignant neoplasm of cervix uteri;Malignant Neoplasms;novel;Oncogenic;Outcome;Participant;Pathogenesis;point of care testing;Population;Pragmatic clinical trial;Pregnant Women;premalignant;Prevalence;Prevention program;Prevention strategy;Principal Investigator;programs;protocol development;Protocols documentation;Province;Public Sector;Recommendation;recruit;Recurrence;Reporting;Research;Research Infrastructure;Research Personnel;Risk;Schools;screening;Secondary Prevention;Services;sex;Sexually Transmitted Diseases;Site;South Africa;Surveys;Testing;treatment optimization;treatment program;United States National Institutes of Health;uptake;Woman;Women's mortality;women's prevention;Work;World Health Organization;young woman

PROJECT_TITLE: CAPRISA CASCADE Clinical Trials Network Clinical Research Site


ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Single cell genomics open new doors to tackle fundamental biological questions by combining the comprehensive nature of genomics with the single cell resolution required to depict complex systems. Successful profiling of single cell genomics can significantly advance the frontier of genomics research and associate these variations with human health and diseases. The aim of this proposal is to develop bioinformatics infrastructures and computational tools for single cell genomics studies

PI_NAMEs: CHEN, MENGJIE  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Achievement;Address;analytical tool;Area;Bayesian Modeling;bioinformatics infrastructure;Biological;biological research;Biomedical Research;cell type;Cells;Cellular Assay;Clinical Research;Communities;Complex;Computer software;computerized tools;Computing Methodologies;conditioning;Data;Databases;Development;differential expression;Disease;Documentation;Enhancers;experimental study;Exposure to;flexibility;frontier;Gene Expression;Genes;genetic architecture;genomic data;Genomics;Goals;Health;Heterogeneity;Human;Immune response;improved;insight;Joints;Knowledge;Maps;method development;Methods;Microscopic;Modeling;Multiomic Data;Nature;open source;Performance;Population;Procedures;Research;Resolution;Sampling;Signal Transduction;single cell analysis;single cell genomics;single cell technology;single-cell RNA sequencing;statistics;Stimulus;System;Technology;Testing;Time;Tissues;tool;trait;transcription factor;transcriptomics;translational study;user friendly software;Variant;Work

PROJECT_TITLE: New directions in single cell genomics method development

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE  Childhood threat exposure (e.g., family/community violence) is a key risk factor for developing suicidal thoughts and behaviors; yet, not all adolescents with childhood threat exposure develop these symptoms. Disruptions to social motivation – the motivations driving the desire and effort to socially interact – may play a role in differentiating suicide risk. The current study will identify whether maladaptive social motivation presentations during adolescence moderate the link between childhood threat exposure and suicidal thoughts/behaviors in an effort to improve risk identification and mechanistic targets for interventions.

PI_NAMEs: BALDELLI, ANDREA PELLETIER (contact)

PROJECT_TERMS: Adolescence;Adolescent;Affect;Age;age effect;aged;Automobile Driving;Award;Behavior;Behavior assessment;behavior measurement;Behavioral;Behavioral Mechanisms;Behavioral Paradigm;biological sex;Brain;career;Cause of Death;Child Abuse and Neglect;Childhood;childhood adversity;Clinical;cohort;community violence;Consult;Consultations;Corpus striatum structure;Cross-Sectional Studies;Data;Data Collection;Development;Doctor of Medicine;Doctor of Philosophy;Evaluation;Exhibits;Expenditure;experience;Exposure to;Family;Feedback;Feeling suicidal;Female;Female Adolescents;Foundations;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Illinois;improved;Individual;Intervention;Interview;Investigation;Knowledge;Link;Longitudinal Studies;Male Adolescents;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Modeling;Motivation;multimodality;National Institute of Mental Health;neural;neurobiological mechanism;neuroimaging;Neurosciences;North Carolina;novel;Parents;Pathway interactions;Patient Self-Report;peer;Process;programs;Psychopathology;Puberty;Punishment;recruit;Reporting;Research;Research Personnel;Rest;Risk;Risk Behaviors;Risk Factors;Role;Scientific Advances and Accomplishments;Self Assessment;Series;Severities;sex;skill acquisition;skills;social;Social Interaction;social stress;Stress;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide prevention;Symptoms;Testing;Time;Training;Training Support;Universities;Washington;Youth

PROJECT_TITLE: Does social motivation in adolescence differentially predict the impact of childhood threat exposure on developing suicidal thoughts and behaviors


ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PUBLIC HEALTH RELEVANCE: Cerebral microbleeds (CMBs), which cause blood to leak across the blood-brain interface (BBI) and form clots within brain tissue, are pervasive in aging, dementia, and numerous other brain disorders. CMBs are strong predictors of stroke, one of the most wide-spread and debilitating brain disorders, whose higher incidence in the early morning and evening suggests vulnerability of the BBI to circadian dynamics. Novel integrative approaches developed under this award to probe the roles of circadian timing in neurovascular coagulation will contribute therapeutic strategies for disease prevention or management, as well as promotion of health and well-being.

PI_NAMEs: GILLETTE, MARTHA U (contact);HAN, BUMSOO ;KONG, HYUNJOON

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Address;Aging;Animal Model;Astrocytes;Award;Behavior;Biomimetics;Blood;Blood - brain barrier anatomy;Blood coagulation;Blood Coagulation Factor;Blood Vessels;Brain;Brain Diseases;brain parenchyma;brain tissue;cell injury;cerebral microbleeds;cerebrovascular;circadian;circadian pacemaker;circadian regulation;Circadian Rhythms;Coagulation Process;Cognition Disorders;Consultations;Crying;Dementia;design;Deterioration;Development;Disease;Disease Management;disorder prevention;Endothelial Cells;Endothelium;Engineering;Event;Exhibits;Extravasation;Fibrin;Fibrinogen;Gait;Genes;glial activation;Goals;Grant;Health Promotion;Hemorrhage;high reward;high risk;Human;human induced pluripotent stem cells;Hypertension;in vivo;Incidence;Infection;Inflammation;inhibitor;innovation;insight;Ischemic Stroke;Knowledge;Lead;Liquid substance;member;Microfluidics;Microglia;millimeter;mimicry;Modeling;Mus;Names;Nerve Degeneration;neuron loss;Neurons;neurovascular;novel;Optics;Outcome;Pattern;Personal Satisfaction;Persons;Pharmacotherapy;Phase;Physiology;Plasma;Plasminogen Activator;Plasminogen Activator Inhibitor 1;Predisposition;pressure;public health relevance;Reporter;Reporter Genes;Reporting;Research;response;Role;Side;Sleep;Sleep Deprivation;Stress;Stroke;stroke incidence;Stroke prevention;Syndrome;System;Testing;Therapeutic;Thrombin;Tight Junctions;Time;tool;Transgenes;translational applications;translational model;Traumatic Brain Injury;United States;Vascular Endothelial Cell;Vascular Endothelium;vascular factor;Venus;Wakefulness

PROJECT_TITLE: Dynamic Circadian Regulation of the Blood-Brain Interface in a Human Brain-mimicking Microfluid Chip


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Maternal Health;Pediatric;Prevention;Teenage Pregnancy;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Avoiding unintended pregnancy and reducing the unmet need for contraception is important for maternal and child health, and of high importance in India especially among young women. Interventions combining life skills and reproductive health empowerment hold potential for reducing unintended pregnancies, but have not been rigorously evaluated. Findings could provide an evidence-based approach to help young women to avoid unintended pregnancies, as well as increasing empowerment.

PI_NAMEs: DIAMOND-SMITH, NADIA GRIFFI (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Affect;aged;arm;Asia;avoid pregnancy;Birth;Child;Child Health;Communication;Communities;Community Health Aides;community led intervention;community organizations;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;cost;Cost Effectiveness Analysis;Data;Decision Making;design;economic evaluation;Economics;effectiveness evaluation;effectiveness/implementation design;empowerment;Enrollment;evidence base;Family;Female Adolescents;Future;future implementation;Goals;group intervention;Health;Health education;health empowerment;health knowledge;Health Resources;Health Services;high risk;High Risk Woman;Household;Household and Family;Husband;implementation research;improved;India;Infant Health;information gathering;Intention;Intermediate Variables;Intervention;intervention effect;Interview;Laws;Life;Life Cycle Stages;Marriage;Maternal and Child Health;Maternal Health;Measures;Mediating;Mediation;Methodology;Methods;Modeling;Mothers;Nepal;Nulliparity;Outcome;parity;parous;Participant;Pathway interactions;Persons;post intervention;Pregnancy;prevent;primary outcome;process evaluation;programs;Randomized;Randomized, Controlled Trials;Reproductive Health;Reproductive Health Services;Research;Resources;Risk;Running;scale up;Services;sex;skills;skills training;standard of care;success;Support Groups;Surveys;Survival Analysis;Testing;Time;time-to-pregnancy;Training;unintended pregnancy;Woman;Work;young woman

PROJECT_TITLE: The impact of group-based life skills and health empowerment for young, married, women to avoid unintended pregnancies in India.

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Fathers play a key role in promoting early child development through their interactions with their children and relationships with their partners. Parenting interventions are needed to holistically support these multiple components of fatherhood and most especially in sub-Saharan Africa, where two-thirds of children under age 5 years are failing to reach their developmental potential. This K99/R00 application proposes training and research to develop expertise in multidisciplinary and cross-cultural theories of early childhood development, fatherhood, and family science; latent profile analysis; and intervention development and evaluation methods to inform the design and feasibility testing of a multicomponent intervention to support fathers’ parenting and couple’s relationships in Tanzania.

PI_NAMEs: JEONG, JOSHUA  (contact)

PROJECT_TERMS: 2 year old;5 year old;Acceleration;acceptability and feasibility;Address;Africa;Africa South of the Sahara;Applications Grants;Area;Award;behavior test;Behavioral;Brain;caregiving;Caring;Child;Child Care;Child Development;Child Nutrition;Child Rearing;Communication;Communities;community intervention;Country;critical period;Data;design;Development;Dimensions;early childhood;effective intervention;Effectiveness;Enrollment;Ensure;Evaluation;evidence base;Evidence based intervention;Exclusion;experience;Family;father role;fatherhood;Fathers;feasibility testing;feasibility trial;Focus Groups;Goals;holistic approach;Household;implementation evaluation;improved;Income;International;Intervention;Knowledge;Life;low and middle-income countries;Malnutrition;Measures;meetings;Mentors;Mentorship;Methodology;Methods;Mother-Child Relations;Mothers;multi-component intervention;multidisciplinary;novel;Observational Study;Outcome;Parent-Child Relations;parenting intervention;Parents;Pathway interactions;Phase;pilot trial;Play;Poverty;Process;professor;programs;Randomized, Controlled Trials;Research;Risk Factors;Role;Rural;Sampling;Science;Scientist;secondary analysis;Shapes;skills;symposium;synergism;Tanzania;tenure track;Testing;theories;therapy design;therapy development;Training;Treatment Efficacy;United States

PROJECT_TITLE: Engaging and Supporting Fathers: A Parenting Intervention to Improve Early Child Development in Tanzania

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Nutrition;Physical Activity;Prevention;Sarcopenia

ORG_CITY: Columbus

ORG_DEPT: NUTRITION

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Sarcopenia is common among older adults and may contribute to functional immobility, loss of independence and hastened mortality. This double-blind randomized controlled trial will test whether supplementing the diet with less than a serving of a linoleate-rich (LA-rich) vegetable oil per day improves muscle strength and physical mobility in older adults with probable sarcopenia. This will also be the first clinical trial to test the effect of fortifying the diet with LA- rich oil on mitochondria, a central mechanistic target could not only affect sarcopenia but other age-associated conditions: e.g., central obesity, insulin resistance, and dyslipidemia.

PI_NAMEs: BELURY, MARTHA A (contact);CLARK, BRIAN C

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Adult;Affect;Age;age related;age related decline;Aging;ATP Synthesis Pathway;Baltimore;Biological Markers;Blood;Cardiolipins;Cardiometabolic Disease;cardiometabolism;Central obesity;Clinical Trials;comparison control;Data;Development;Diet;dietary;dietary approach;Dietary intake;disorder risk;Double-Blind Method;Dyslipidemias;Electron Transport;epidemiologic data;Essential Fatty Acids;Event;Exercise;Extensor;Extravasation;fall risk;Fatigue;FDA approved;Fortification;Gait speed;Health;Health Care Costs;health data;Human;Immobilization;Impairment;improved;Inner mitochondrial membrane;innovation;Insulin Resistance;Intake;Intramuscular;Isotonic Exercise;Leg;Lifestyle Therapy;Link;linoleates;Linoleic Acids;long chain fatty acid;Longitudinal Studies;Lysophosphatidylcholines;Mammals;Measures;Methods;Mitochondria;mitochondrial dysfunction;Mobility decline;Morbidity - disease rate;mortality;Mus;Muscle;muscle form;Muscle function;muscle strength;Muscle Weakness;Muscular Atrophy;Nutritional Requirements;Oils;older adult;older men;Older Population;older women;Oleic Acids;Omega-3 Fatty Acids;Outcome;Pathologic;Pattern;peer;Persons;Pharmaceutical Preparations;Phase;phase II trial;Phospholipids;Physical activity;Physical Function;physical impairment;Placebos;Plasma;Postmenopause;prevent;Prevention;primary outcome;Probability;Production;protective effect;protein intake;Protons;Randomized, Controlled Trials;Recommendation;Reporting;Resistance;resistance exercise;Respiration;Risk;Rodent Model;Role;sarcopenia;scaffold;Side;Skeletal Muscle;skeletal muscle wasting;Source;Specific qualifier value;Supplementation;targeted treatment;Testing;Therapeutic;Thinness;Tissues;Triglycerides;Vegetable Oils;Woman

PROJECT_TITLE: Improving sarcopenia by targeting mitochondria

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Neurosciences;Nutrition

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Avoidant/restrictive food intake disorder (ARFID) is a serious and impairing feeding and eating disorder that affects 1-3% of children and 1-4% of adults, resulting in weight loss, nutritional deficiencies, dependence on nutritional supplements, and/or psychosocial impairment. The PI, Dr. Jennifer Thomas, is an expert in patient- oriented research in feeding and eating disorders and has a strong commitment to mentorship of junior colleagues. This K24 award will enable her to grow her skills in multimodal neuroimaging, establish a new line of research to identify structural brain abnormalities that may contribute to ARFID etiology or maintenance, and create a sustainable infrastructure for continued research mentorship of diverse scholars across disciplines and institutions with the goal to develop them into independent clinical researchers who can successfully fulfil the NIMH strategic plan.

PI_NAMEs: THOMAS, JENNIFER JOANNE (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Adult;Affect;Amygdaloid structure;Anisotropy;Authorship;avoidant restrictive food intake disorder;Award;Behavior Therapy;biobehavior;Body Weight decreased;Brain;brain abnormalities;Brain imaging;career;career development;Child;Choking;Chronic;Clinical;Clinical Research;Clinical Trials Design;Corticospinal Tracts;Cues;Data;Dedications;Dependence;dietary supplements;Diffusion Magnetic Resonance Imaging;digital mental health;Discipline;Doctor of Philosophy;early satiety;Eating Disorders;Ecological momentary assessment;Environment;Etiology;experience;feeding;Food;food avoidance;food restriction;Foundations;Fright;Functional disorder;Functional impairment;Functional Magnetic Resonance Imaging;Funding;Future;General Hospitals;Goals;Grant;gray matter;Hormones;Hunger;Hyperactivity;Hypothalamic structure;Impairment;Incubators;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Laboratories;Leadership;Link;Maintenance;Malnutrition;Maps;Massachusetts;median forebrain bundle;medical schools;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);mid-career faculty;multidisciplinary;multimodal neuroimaging;multimodality;National Institute of Mental Health;Negative Valence;Neurobiology;Neurocognitive Deficit;neuromechanism;Neurosecretory Systems;next generation;novel;Paper;Pathway interactions;Patient Care;patient oriented research;Pattern;Perception;Phenotype;programs;Psychiatry;Psychology;psychosocial;Publications;Publishing;Research;Research Domain Criteria;Research Personnel;Resources;response;restrictive eating;Sensory Disorders;skills;Somatosensory Cortex;Strategic Planning;stria terminalis;Structure;Symptoms;Taste Perception;Techniques;Texture;Time;Training;Vomiting;Weight;white matter

PROJECT_TITLE: Mentorship in Biobehavioral Mechanisms of Avoidant/Restrictive Food Intake Disorder

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE Because neurons compute by integrating electrical (voltage) signals from connected cells, methods to track these signals are critical to understanding the brain in health and disease. However, current tools can only record rapid voltage changes in 2D while the brain and neurons are organized in 3D. The research project proposes new microscopy methods and biosensors to address this critical limitation and enable the recording of rapid electrical activity in three dimensions.

PI_NAMEs: BOURDIEU, LAURENT ;ST-PIERRE, FRANCOIS  (contact)

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TITLE: ENABLING SUBMILLISECOND-TIMESCALE TWO-PHOTON RECORDING OF VOLTAGE DYNAMICS IN THREE DIMENSIONS IN VIVO


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ATHENS

ORG_NAME: CYANVAC, LLC

PHR: NARRATIVE The purpose of this R21 proposal is to develop an intranasal vaccine for both respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) using parainfluenza virus 5 (PIV5) as a viral vector. RSV and HMPV are significant causes of acute lower respiratory tract infections in young infants and the elderly, but there is currently no licensed vaccine. The use of this novel PIV5 platform for intranasal vaccine development will help generate a safe and effective vaccine for both viruses that can potentially be used to combat this public health threat.

PI_NAMEs: GINGERICH, MARIA CRISTINA (contact);MOUSA, JARROD

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: 10 year old;2 year old;Acute;Acute respiratory infection;Adjuvant;Affect;Age;Antibodies;Antibody Response;Antigens;Binding;Biological Assay;Blood group antigen f;Bronchiolitis;Canis familiaris;cell mediated immune response;Cells;Child;Childhood;Chimeric Proteins;combat;Cytoplasmic Tail;Data;delivery vehicle;design;Disease;Distemper;Dose;Elderly;Epitopes;FDA approved;Genes;Genome;Glycoproteins;Goals;Growth;GTP-Binding Proteins;Hospitalization;Human;Human Metapneumovirus;Immune response;Immunization;Immunocompromised Host;Immunodominant Epitopes;Immunofluorescence Immunologic;immunogenic;immunogenicity;Immunoglobulin G;improved;In Vitro;in vivo;in vivo evaluation;Individual;Infant;Infection;Influenza;Integral Membrane Protein;Kinetics;Licensing;Lower Respiratory Tract Infection;Lower respiratory tract structure;Mediating;Medical;Methods;Mind;Modification;Molecular Conformation;Monoclonal Antibodies;mouse model;Mucosal Immunity;Mus;Needles;neutralizing antibody;novel;older adult;older patient;parainfluenza virus;pathogen;pathogenic virus;pediatric patients;Phase I Clinical Trials;Phenotype;Plasmids;Pneumonia;protective efficacy;protein expression;protein purification;Proteins;Public Health;Rabies;recombinant virus vaccine;research clinical testing;respiratory pathogen;Respiratory syncytial virus;Respiratory syncytial virus RSV F proteins;Respiratory Syncytial Virus Vaccines;RNA;Safety;SARS coronavirus;Serum;Site;Structure;success;Surface;Symptoms;Tail;Target Populations;Testing;Transfection;Transmembrane Domain;Upper Respiratory Infections;Upper respiratory tract;Vaccination;vaccine access;vaccine candidate;vaccine development;vaccine efficacy;vaccine platform;Vaccines;vector;vector vaccine;Vero Cells;Vertebral column;Viral Vector;Virus;Virus Diseases

PROJECT_TITLE: A parainfluenza virus 5 (PIV5)-based bivalent vaccine for respiratory syncytial virus (RSV) and human metapneumovirus (HMPV)

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Prevention

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative Neural connections mapped in the macaque brain can improve our understanding of the brain circuits involved in avoidance symptoms, such as those observed in obsessive-compulsive disorder (OCD). This project will combine macaque neuroanatomy with neuroimaging data in humans to describe circuitry-level biomarkers for these symptoms. Later, during a new neuromodulation protocol, OCD patients will receive training to self- modulate the local activity within these biomarkers while receiving real-time feedback.

PI_NAMEs: TRAMBAIOLLI, LUCAS R (contact)

PROJECT_TERMS: Affect;Algorithms;anatomical tracing;Anatomy;Anterior;anxiety symptoms;Area;Attention;attentional bias;Award;Biological Markers;biomarker discovery;blood oxygen level dependent;Brain;career;cingulate cortex;Clinical;Clinical assessments;clinical training;Clinical Trials Cooperative Group;Complementary therapies;Complex;Corpus striatum structure;Data;data acquisition;Data Analyses;Dedications;Development;Devices;Diagnosis;Disease;Education;emotion regulation;Emotions;Environment;experience;Feedback;Foundations;frontal lobe;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;General Hospitals;Goals;hemodynamics;Hospitals;Human;improved;insight;interest;Intervention;Learning;Location;Macaca;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Maps;Massachusetts;medical schools;Mental disorders;Mental Health Services;Mentors;Methods;Modality;Modeling;multimodal neuroimaging;multimodality;neural;neural circuit;Neuroanatomy;neurofeedback;neuroimaging;neuroregulation;nonhuman primate;Normalcy;Obsessive-Compulsive Disorder;Participant;Pathway interactions;Patients;Pattern;Pharmacological Treatment;Pharmacology;Phase;Physician Executives;Physiology;Population;Postdoctoral Fellow;potential biomarker;Prefrontal Cortex;preservation;professor;Protocols documentation;Psychiatry;Psychopathology;Publications;reduce symptoms;Regional Anatomy;Research;Rest;Role;Scientist;signal processing;Signal Transduction;Solid;Specificity;Stimulus;symptomatic improvement;symptomatology;Symptoms;targeted biomarker;Technology;Testing;Therapeutic;Time;Tracer;Training;Translating;translational model;Translations;Universities;Visit

PROJECT_TITLE: Neuroanatomically informed biomarker discovery and neurofeedback intervention for OCD


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health;Substance Misuse

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: NARRATIVE Disruption of social networks due to displacement, conflicts, economic migration or climate crises can have detrimental effects on the health and wellbeing of people at risk of and living with HIV. Changes in social network composition due to these events can create avenues for increased stigma, particularly among groups historically stigmatized, such as men who have sex with men (MSM) in Ukraine, and enable new pathways for HIV transmission. We will implement social network methods and phylogenetic analysis to evaluate the effect of social network disruption on MSM stigma, substance use disorders, HIV risk behaviors, and HIV transmission and care dynamics among forcibly displaced MSM in Ukraine.

PI_NAMEs: VASYLYEVA, TETYANA  (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Address;Affect;AIDS prevention;Air;Area;Behavioral;Blood specimen;Capital;care systems;Caring;Cities;climate crisis;cohesion;Communities;Conflict (Psychology);Country;Data;Discrimination;displaced person;Economics;Epidemic;Europe;Event;experience;Face;follow-up;Friends;Genetic;Goals;Health;High Prevalence;HIV;HIV diagnosis;HIV risk;HIV Seronegativity;HIV Seropositivity;Human immunodeficiency virus test;Infrastructure;Intervention;Interview;Invaded;Location;marginalized population;Medical;men who have sex with men;Methods;Migrant;migration;Military Personnel;Participant;Pathway interactions;Patient Recruitments;Personal Satisfaction;Persons;Phylogenetic Analysis;Populations at Risk;Prejudice;Prevalence;prevention service;primary outcome;promote resilience;recruit;Respondent;Risk;Risk Behaviors;risk minimization;Sampling;Services;Sex Behavior;Sex Orientation;social culture;Social Network;social stigma;Social support;Stigmatization;stressor;Substance Use Disorder;support network;Testing;transmission process;Ukraine;United States National Institutes of Health;Viral;Viral Load result;War

PROJECT_TITLE: Social network disruption, stigma, and HIV transmission and care dynamics among forcibly displaced MSM in Ukraine

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE During development, functional circuits between the approximately 80 billion human neurons connecting trillions of synapses must be established. Disruption in proper neural circuit formation has been associated with a number of neurodevelopmental and neuropsychiatric disorders. This proposal will investigate how the clustered protocadherins, which provide each neuron the unique cell specific identity needed for self- identification, initiate the intracellular signaling events required for self-avoidance, which may provide new insights into the etiology of neurodevelopmental disorders.

PI_NAMEs: FLAHERTY, ERIN  (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Address;autism spectrum disorder;Award;axon guidance;Behavior;Biological;Biophysics;Brain;Cell membrane;Cell Nucleus;Cells;Cellular Assay;Chromatin;Complex;Cytoplasm;Data;Development;Dimerization;Disease;disease model;Etiology;Evaluation;Event;Faculty;Feedback;Foundations;Gene Cluster;Gene Expression;gene function;Genes;Genetic;genetic approach;Genetic Transcription;Goals;GTP-Binding Proteins;Human;In Vitro;in vivo;in vivo Model;Individual;induced pluripotent stem cell;insight;Institution;Integral Membrane Protein;Knowledge;Laboratories;Learning;Link;Lymphocyte;Mammals;Mediating;Membrane;membrane biogenesis;Mentors;Mentorship;Microfilaments;Modeling;Molecular;Movement;Mus;Needs Assessment;neural;neural circuit;Neurites;neurodevelopment;Neurodevelopmental Disorder;neuronal circuitry;Neurons;neuropsychiatric disorder;notch protein;novel;Nuclear;Organoids;Patients;Phase;Positioning Attribute;Postdoctoral Fellow;proband;Process;protein function;Protein Isoforms;Proteins;Research;Role;Schizophrenia;Scientist;screening;Series;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;Sister;Structure;Surface;Synapses;Synaptic Transmission;synaptogenesis;Techniques;Tertiary Protein Structure;Testing;Training;Transcriptional Regulation;Variant;Vertebrates;WNT Signaling Pathway;Work

PROJECT_TITLE: The role of the protocadherin gene cluster in neurodevelopment and the implications for neurodevelopmental disorders


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;HIV/AIDS;Heart Disease;Infectious Diseases;Mental Health;Prevention

PHR: PROJECT NARRATIVE The proposed study will establish the feasibility and acceptability of a novel, text-enhanced integrative behavioral intervention “One Mind-One Heart (OM-OH),” aimed at reducing cardiovascular disease (CVD) risk in older people with HIV (OPWH). By addressing CVD, a significant comorbidity that affects a growing number of OPWH in psychological distress due to shared pathophysiology linked to systemic inflammation, this work will be instrumental in improving the health and well-being of PWH across the lifespan.

PI_NAMEs: FOLEY, JACKLYN DONNA (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: acceptability and feasibility;Acute myocardial infarction;Address;Affect;aged;Alcohol consumption;Alcohols;Amaze;Atherosclerosis;Automobile Driving;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral Medicine;Behavioral Sciences;Benchmarking;Biological;Biological Markers;Blood Pressure;Breathing;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cellular Phone;Chronic;Clinical;Clinical Trials;Communicable Diseases;comorbidity;diabetes prevention program;Disease;Dose;Education;effective intervention;efficacy trial;eHealth;Elements;endothelial dysfunction;Environment;evidence base;Exercise;experience;Feedback;Foundations;Functional disorder;General Hospitals;General Population;Goals;Health;Health behavior;health management;Heart;Heart failure;HIV;HIV/AIDS;Immune;Immune response;impaired glucose tolerance;improved;Inflammation;Inflammatory;Informal Social Control;innovation;Institution;Integrative Medicine;Interdisciplinary Study;interest;Intervention;intervention refinement;Interview;Ischemic Stroke;Language;Licensing;life span;Link;Massachusetts;Mediating;medical schools;meetings;Mental disorders;Mentors;Mentorship;Methods;Mind;mindfulness;mindfulness intervention;mindfulness-based stress reduction;mobile computing;Modality;Modeling;Movement;multidisciplinary;National Heart, Lung, and Blood Institute;novel;Older Population;Patient Self-Report;Personal Satisfaction;Persons;Phase;physical inactivity;pilot test;programs;Protocols documentation;psychologic;psychological distress;Psychologist;Psychology;Publications;Publishing;Qualitative Methods;Randomized, Controlled Trials;Research;Research Design;Research Infrastructure;Research Personnel;Research Priority;Risk;Risk Behaviors;Risk Reduction;Sampling;Self Efficacy;skills;Stress;Structure;substance use;Symptoms;systemic inflammatory response;Text;Text Messaging;text messaging intervention;therapy development;Tobacco smoking behavior;Training;Training Programs;treatment as usual;trial design;Unhealthy Diet;United States;uptake;Woman;Work

PROJECT_TITLE: Mindfulness and Behavior Change to Reduce Cardiovascular Disease Risk in Older People with HIV

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Natural Products;Nutrition;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Senescent cells accumulate after chemotherapy or radiation and produce factors that cause systemic inflammation, tissue damage, and frailty. Fisetin is a nutritional supplement that ablates senescent cells; in preclinical models, fisetin reduces senescent cells and downstream inflammation and frailty. This trial will test the safety, tolerability, and preliminary efficacy of fisetin at reducing frailty in a sub-population of older cancer survivors who were previously treated with chemotherapy or radiation and now suffer from frailty.

PI_NAMEs: SEDRAK, MINA S (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Ablation;Acceleration;Adverse event;Age;age acceleration;age related;Age Years;Aging;aging mechanism;aging process;anti-cancer treatment;Automobile Driving;Award;Biological;Biological Markers;Blood;cancer clinical trial;Cancer Patient;Cancer Survivor;cancer therapy;career;CDKN2A gene;Cell Aging;Cessation of life;chemotherapy;Chemotherapy and/or radiation;childhood cancer survivor;Clinical;Data;Diet;dietary supplements;Double-Blind Method;Eating;efficacy trial;experience;Exposure to;falls;fisetin;Flavonoids;Food;Frail Elderly;frailty;Fruit;Funding;Gait speed;Generations;geroprotector;Geroscience;Goals;Growth;Half-Life;Hand Strength;Health;human old age (65+);human tissue;improved;indexing;Inflammation;Inflammatory;Infrastructure;Interleukin-6;Intervention;Intervention Studies;Link;Malignant Neoplasms;Measures;mouse model;Multi-Institutional Clinical Trial;multimodality;Natural product discovery;Natural Products;normal aging;Normal tissue morphology;older adult;Oral;Outcome;Patient Outcomes Assessments;Persons;Pharmaceutical Preparations;pharmacologic;Physical Function;Placebos;Pre-Clinical Model;primary endpoint;Process;programs;Proteins;Publishing;Radiation;Randomized;randomized placebo controlled trial;Research;Risk;Safety;safety assessment;safety testing;secondary endpoint;senescence;senescence associated secretory phenotype;senescent cell;senolytics;side effect;skills;Strawberries;Survivors;systemic inflammatory response;T-Lymphocyte;Testing;Tissues;Training;treatment adherence;tumor;young adult

PROJECT_TITLE: Targeting Senescence to Improve Frailty in Older Cancer Survivors


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Infectious Diseases;Malaria;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Vector-Borne Diseases

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative We propose to develop a novel state-of-the-art “chip” device that mimics the cell interface between the blood and the brain. We will use the chip it to understand how malaria, a disease that kills causes brain damage in children world-wide, communicates with the brain blood vessels through exosomes, particles surrounded by membranes that are involved in communication between cells. We will analyze the contents of the exosomes and evaluate their effect on the cells in the “chip” to elucidate new ways to prevent or predict the brain damage caused by the parasite.

PI_NAMEs: GOLIGHTLY, LINNIE  (contact);GYAN, BEN ADU;LIS, RAPHAEL ;LYDEN, DAVID CHARLES

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Adherence;Admixture;Affect;Animal Model;Atlases;Autopsy;Biological Assay;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;Brain;brain endothelial cell;Brain Injuries;Cancer Biology;cancer cell;CD36 gene;Cell Line;Cell Separation;Cells;Central Nervous System;Cerebral Malaria;cerebral microvasculature;Cerebrovascular system;Child;Clinical;Communication;Communities;Data;Derivation procedure;Development;Devices;Disease;disease model;early onset;Education;Endothelial Cells;Epithelial Cells;Erythrocytes;Erythroid;exosome;extracellular vesicles;FLI1 gene;Functional disorder;Generations;Genetic;Ghana;Hemorrhage;Human;improved;In Vitro;in vitro Model;induced pluripotent stem cell;Infection;Inflammatory;innovation;insight;intercellular communication;Malaria;Malignant Breast Neoplasm;Mass Spectrum Analysis;Mediating;Membrane;Metastatic malignant neoplasm to brain;Methods;Microfluidic Microchips;Microfluidics;Modeling;Molecular;Molecular Profiling;Monitor;mouse model;Mus;new technology;novel;organ on a chip;Organoids;Parasites;particle;Pathogenesis;Pathology;Patients;Perfusion;Pericytes;Peripheral;Pharmaceutical Preparations;Phase;Physiological;Plasma;Plasmodium falciparum;pluripotency;Pluripotent Stem Cells;prevent;progenitor;prognosis biomarker;Proteins;Proteome;proteomic signature;Proteomics;Protocols documentation;Regulation;Resources;response;Role;single-cell RNA sequencing;Source;stem cells;Survivors;Syndrome;Technology;Testing;TFRC gene;Time;tool;trait;transcription factor;transcriptomics;tumor;uptake;Vascular Endothelial Cell;Vascularization;Whole Blood

PROJECT_TITLE: In vitro modeling of blood brain barrier dysfunction on a chip to elucidate the pathogenesis of cerebral malaria


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Framingham

ORG_NAME: KEPHERA DIAGNOSTICS, LLC

PHR: Project Narrative This project addresses the critical need for a test of treatment response for Chagas disease, which has emerged as a threat to public health and the blood supply both within the U.S. and internationally. Determining whether treatment of patients for Chagas disease new or existing drugs is successfully eradicating the infection requires a test, but no such test has been validated and commercialized for this intended use. We have developed a Chagas disease test of treatment response based on novel peptide antigens in Phase I, in both laboratory and point-of-care formats. In Phase II we will refine the test into manufactured products, carry out a clinical study to validate assay performance, and prepare for scale up and commercial launch of the assay.

PI_NAMEs: LEVIN, ANDREW E. (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Acute;Address;Adherence;Adult;Adverse effects;Aftercare;Age;aged;Antibody titer measurement;Antigens;Benznidazole;Biological Assay;Biological Markers;Blood Screening;Blood Transfusion;Brazil;Cardiac;Cardiomyopathies;Chagas Disease;Characteristics;Child;Chronic;chronic infection;Chronic Phase;Clinical;Clinical Management;clinical prognosis;Clinical Research;Clinical Trials;cohort;commercial launch;commercialization;Controlled Environment;curative treatments;Data;Dedications;design;Detection;detection method;Development;Diagnosis;diagnostic assay;Disease;dosage;drug testing;Enzyme-Linked Immunosorbent Assay;Epitopes;Evaluation;FDA approved;gastrointestinal;health organization;Immigrant;Immune response;Immunoglobulin G;Individual;individual patient;Infection;Insect Vectors;International;Label;Laboratories;Lateral;lateral flow assay;Latin America;Length;Malabsorption Syndromes;manufacture;manufacturing scale-up;Measures;Methodology;Methods;Morbidity - disease rate;mortality;Newly Diagnosed;Nifurtimox;novel;novel therapeutics;Organ Transplantation;Outcome;Parasites;Parasitic Diseases;Parasitic infection;Pathologic;patient response;Patients;Peptides;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Phase;point of care;Population;Preparation;Prevalence;prevent;Process;prospective;Prospective cohort;Proteins;Protocols documentation;prototype;Public Health;Reproducibility;Research;research and development;research study;response;Retrospective cohort;Risk;Rural;Sampling;scale up;Serodiagnoses;Serology;Serology test;Serum;Services;Standardization;synthetic peptide;Testing;Time;time interval;Toxic effect;Training;Transfusion;transmission process;Treatment Failure;treatment response;Trypanosoma cruzi;Validation;validation studies;Vascular blood supply

PROJECT_TITLE: Biomarker-Based Test of Cure for Chagas Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-E(13)]


ORG_CITY: BIRMINGHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE There is a need to understand the molecular mechanisms responsible for pro-fibrotic responses in idiopathic pulmonary fibrosis. Post-transcriptional regulation plays a fundamental role in regulation of gene expression during normal and diseased conditions. This proposal is to understand the novel mechanism contributing to dysregulated post-transcriptional regulation that leads to lung fibrosis.

PI_NAMEs: CHE, PULIN  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Apoptotic;Bleomycin;Cell Differentiation process;Cells;Collagen;crosslink;Cytoplasmic Protein;Cytoskeleton;Data;Deposition;Disease;Down-Regulation;driving force;effective therapy;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;fibrogenesis;Fibronectins;Fibrosis;Focal Adhesions;Fostering;Gene Expression Regulation;genetic regulatory protein;Genetic Transcription;Goals;Human;idiopathic pulmonary fibrosis;Impairment;in vivo;Integrins;loss of function;Lung;Mediating;Messenger RNA;Molecular;Mus;Myofibroblast;novel;Pathologic;Play;Post-Transcriptional Regulation;posttranscriptional;Production;Profibrotic signal;Protein Deficiency;protein expression;protein function;Proteins;Pulmonary Fibrosis;Reaction;recruit;response;RNA Splicing;RNA Stability;Role;Signal Transduction;Testing;Tissues;Wild Type Mouse

PROJECT_TITLE: Post-Transcriptional Regulation of Lung Fibrosis.

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE This proposal addresses changes in attention brain network function as a cognitive compensatory process in subjective cognitive decline (SCD). I aim to examine the relationships between Alzheimer’s Disease (AD) related pathology and neurotransmitter mechanisms that may underlie the maintenance of normal cognitive performance despite SCD in aging. The results of this study will improve our understanding of the neurobiological mechanisms supporting cognitive compensation in the early stages of pathological cognitive decline and support future work developing cognitive interventions in AD.

PI_NAMEs: ALBERT, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Academic Medical Centers;Address;Affect;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-42;Amyloidosis;Anti-Cholinergics;Attention;basal forebrain;Behavioral Sciences;Brain;career;career development;cholinergic;Clinical;clinical diagnosis;Clinical Research;Clinical Trials;Cognition;Cognition Disorders;Cognitive;Cognitive aging;cognitive change;cognitive enhancement;cognitive function;cognitive neuroscience;cognitive performance;cognitive process;cognitive testing;Collaborations;Compensation;Complement;Deterioration;Development;Disease;Disease Progression;Doctor of Philosophy;Electroencephalography;Environment;experience;Experimental Models;Failure;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Funding;Future;Goals;Human;Impaired cognition;Impairment;improved;Individual;Intervention;Intervention Studies;K-Series Research Career Programs;Leadership;Maintenance;Measures;Medial;medial temporal lobe;Medicine;Memory;Mentors;neurobiological mechanism;Neurobiology;neuroimaging;neuropathology;Neurosciences;Neurotransmitters;older adult;Pathologic;Pathology;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Placebos;pre-clinical;preservation;Process;professor;Psyche structure;Psychiatry;Research;Research Personnel;Research Project Grants;Research Proposals;research study;Resources;Role;Severities;System;tau Proteins;temporal measurement;Testing;Therapeutic;Training;Translating;Work

PROJECT_TITLE: Attentional Mechanisms of Cognitive Compensation in Subjective Cognitive Decline and AD Risk

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]