ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Hearing complaints such as tinnitus (ringing in the ears), hyperacusis (intolerance to loud sounds), and difficulty understanding speech in noisy environments are commonly reported by Veteran patients even when their hearing test is clinically normal. Unfortunately, there is a lack of consensus among clinicians about the best way to manage these patients because treatment options are limited and the outcomes are variable. One of the major barriers to developing treatments for this patient population is that although these patients likely represent a heterogeneous population with etiologies including lesions to the peripheral and central auditory system as well as cognitive deficits, there are currently no test measures that can pinpoint the damage location. This project will enable differential diagnosis of damage to the peripheral auditory system and will characterize the auditory perceptual deficits associated with peripheral damage. This will have a positive impact on Veterans' health because it will allow for the future development of treatments that are specific to the underlying auditory deficit.

PI_NAMEs: BRAMHALL, NAOMI  (contact)

PROJECT_TERMS: Acoustic Nerve;Algorithms;Animal Model;Audiology;Auditory;Auditory Brainstem Responses;Auditory system;Auditory Threshold;cell injury;Cell Physiology;Clinical;Clinical assessments;clinical candidate;clinical practice;Cochlea;Cognitive deficits;cognitive load;Complex;Consensus;Data;Deafferentation procedure;Diagnosis;Differential Diagnosis;Ear;ear muscle;Environment;Etiology;Future;Health;Hearing;Hearing Aids;Hearing problem;Hearing Tests;high risk population;Hyperacusis;individual patient;Inner Hair Cells;innovation;Least-Squares Analysis;Lesion;Location;Loudness;Measurement;Measures;middle ear;military service;Natural regeneration;Nature;Nerve Fibers;Noise;noise exposure;normal hearing;otoacoustic emission;Outcome;Outer Hair Cells;patient population;Patients;Peripheral;Persons;Pharmacotherapy;Physiological;Population Heterogeneity;prevent;Publishing;Recommendation;Recording of previous events;Reference Values;Reflex action;repaired;Reporting;Research;research clinical testing;response;Risk;Sampling;sex;Site;sound;Speech;Speech Perception;Stimulus;Synapses;Testing;therapy development;Tinnitus;Traumatic Brain Injury;Treatment outcome;Veterans;Weight

PROJECT_TITLE: Resolving the Paradox of Hearing Complaints with a Normal Audiogram: Differential Diagnosis and Perceptual Impacts of Cochlear Deafferentation

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Mechanisms of learning and memory and their dependence on behavioral contexts have important implications in memory disorders such as Alzheimer's disease and age-related dementia, as well as post-traumatic stress disorders. The olfactory bulb adult neurogenesis presents an excellent model for studying experience- dependent plasticity. We propose to study the cellular and circuit mechanisms for the context specificity of synaptic structural plasticity of adult-born neurons in the olfactory bulb.

PI_NAMEs: KOMIYAMA, TAKAKI  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Adult;adult neurogenesis;Affect;Age;age related;Alzheimer's Disease;Apical;Area;Behavioral;Behavioral Mechanisms;Brain;Calcium;Cells;Clinical;Dementia;Dendrites;Dendritic Spines;density;Dependence;Diagnosis;Discrimination;discrimination task;Disease;Emotional;Ensure;Event;experience;Feedback;Future;Glutamates;granule cell;Head;Image;in vivo;in vivo calcium imaging;in vivo two-photon imaging;inhibitory neuron;insight;Learning;Memory;Memory Disorders;Methodology;Modeling;Monitor;Mus;neural circuit;Neuronal Differentiation;Neuronal Plasticity;Neurons;odor discrimination;Odors;olfactory bulb;Olfactory Learning;Olfactory Pathways;optogenetics;Pathway interactions;Pattern;piriform cortex;Play;Post-Traumatic Stress Disorders;Process;recruit;Reporting;Role;Specificity;Stimulus;structural imaging;Structure;Study models;Synapses;Synaptic plasticity;Techniques;Testing;two-photon;Vertebral column;young adult

PROJECT_TITLE: Context-dependent plasticity of adult-born neurons

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Genetics;Heart Disease;Human Genome;Mental Health;Microbiome;Prevention;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: MULTI-OMICS CORE C NARRATIVE Early life stress is a significant and understudied risk factor for increasing cardiovascular disease risk later in life. Core C will prepare samples and coordinate multiple genome wide analyses (multi-omics) from the level of a single nucleus to the tissue for all the Projects in this grant application. Centralizing the multi-omic approaches in Core C will ensure rigor and reproducibility of experimental design and data collection to meet the goals of this highly functioning PPG.

PI_NAMEs: HYNDMAN, KELLY  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acetylation;Address;Adult;Animals;Applications Grants;ATAC-seq;Basic Science;bench to bedside;Bioinformatics;Biometry;cardiovascular disorder risk;Cell Nucleus;Cells;Chromatin;Chromatin Structure;Clinical;Cost Savings;Data;Data Analyses;Data Collection;data management;data submission;Deposition;DNA;DNA Methylation;DNA Sequencing Facility;early life stress;Ensure;Environment;epigenetic regulation;epigenome;epigenomics;experience;Experimental Designs;experimental study;Genes;genome-wide analysis;Genomics;Goals;gut microbiome;Histone Deacetylase;Human;innovation;innovative technologies;Institution;Kidney;Life;Link;Liquid Chromatography;Lysine;Mass Spectrum Analysis;Mediating;member;metabolome;metabolomics;Methods;methylome;microbial;microbiome;microbiome research;multiple omics;new technology;Preparation;Proteins;Proteomics;Protocols documentation;Quality Control;Reagent;Regulation;repository;Reproducibility;resilience;Resolution;Risk;Risk Factors;RNA;Rodent;sample collection;Sampling;single nucleus RNA-sequencing;Standardization;Structure;synergism;tandem mass spectrometry;Techniques;Technology;technology platform;Testing;Tissues;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Volatile Fatty Acids;Work

PROJECT_TITLE: Multi-Omics Core C

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The University of Iowa Child Health Research Career Development Award will ultimately improve the health and well-being of children through innovative research fostered by development of newly trained and highly effective clinician scientists.

PI_NAMEs: BASSUK, ALEXANDER G (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Academic support;Advisory Committees;Animal Model;Applied Genetics;Area;Award;Basic Science;Biological;career;career development;Cellular biology;Child Health;Child Welfare;Childhood;Clinical;college;design;Development;Disease;Effectiveness;Environment;experience;Faculty;faculty mentor;Feedback;Fostering;Future;Genes;Genetic study;Genomics;Goals;Health;Host Defense;human disease;human model;improved;Inflammation;innovation;Instruction;Iowa;K-Series Research Career Programs;Medical;Medicine;meetings;Minority;Molecular;Molecular and Cellular Biology;Molecular Biology;Molecular Genetics;National Institute of Child Health and Human Development;Neurosciences;Neurosciences Research;operation;pediatric department;Pediatric Research;Physicians;Physiological;Physiology;Program Reviews;programs;Recording of previous events;recruit;Regulation;Research;Research Personnel;Research Training;Schedule;Scientist;senior faculty;skills;Talents;Training;Translational Research;Universities;Whole Organism;Woman

PROJECT_TITLE: Molecular and Cellular Research to Advance Child Health


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE This is a proposal for a K24 Midcareer Investigator Award in Patient-Oriented Research for Kelly E. Dooley, MD, PhD. This award will support Dr. Dooley’s mentorship of new and existing young investigators and her clinical research programs which are focused on improving tuberculosis (TB) therapeutics and optimizing treatment of HIV-associated TB, using clinical pharmacology as a powerful tool for doing so. The overarching goals of her research are to improve the treatment of drug-sensitive and drug-resistant TB, TB meningitis, and mycobacterial diseases, and to ensure new treatments are available to those patients who need them most, including populations such as children, pregnant women, and patients living with HIV, all through well-designed clinical research.

PI_NAMEs: DOOLEY, KELLY E. (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Address;AIDS clinical trial group;Antimycobacterial Agents;Area;Attention;Award;Biological Markers;biomarker discovery;biomarker identification;Brain;Bronchiectasis;career;Cause of Death;Cerebrospinal Fluid;Child;Clinical;Clinical Drug Development;Clinical Pharmacology;Clinical Research;Clinical Trials;Clinical Trials Network;Cohort Studies;Collaborations;Communicable Diseases;contextual factors;Data;design;Development;Disease;Doctor of Philosophy;Dose;Drug Delivery Systems;drug development;drug distribution;Drug Interactions;Drug resistance in tuberculosis;drug-sensitive;Ensure;experience;Foundations;Funding;Goals;HIV;HIV/TB;improved;Individual;innovation;Interdisciplinary Study;interest;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Investigation;Irreversible Toxicity;Isoniazid resistance;K-Series Research Career Programs;Knowledge;knowledge base;Lead;Leadership;Learning;Medical;Medicine;member;Meningeal Tuberculosis;Mentors;Mentorship;mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;Molecular;Multidrug-Resistant Tuberculosis;mycobacterial;next generation;non-tuberculosis mycobacteria;novel therapeutics;optimism;Pathway interactions;patient oriented research;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;pharmacometrics;Phase;Physicians;Population;Positioning Attribute;pre-clinical;Pre-Clinical Model;Pregnant Women;Prevalence;programs;Regimen;Research;Research Design;Research Personnel;Rifampin;Role;Safety;Science;Scientist;Site;skills;Special Population;Specialist;Testing;Therapeutic;Therapeutic Research;Time;tool;Training;treatment optimization;treatment research;treatment response;treatment trial;trial design;Tuberculosis;tuberculosis drugs;tuberculosis treatment;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Mentoring Investigators in HIV and Tuberculosis Therapeutics Research

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness;Suicide;Suicide Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Suicide is a serious public health crisis and a leading cause of death in young adults, especially among those with borderline personality disorder (BPD). Results from this study will advance understanding of dyadic interpersonal mechanisms within romantic relationships that exacerbate and maintain suicide risk in young adults, including those with and without BPD. The ultimate impact of this work is to inform improved, evidence- based assessment tools, identify new targets for intervention, and develop partner-involved intervention strategies to reduce suicide risk and improve psychosocial functioning in vulnerable young adults.

PI_NAMEs: SCOTT, LORI N;STEPP, STEPHANIE D (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Address;Affect;Age;Arousal;Assessment tool;Behavior;biopsychosocial;Borderline Personality Disorder;Cause of Death;Code;Communication;Conflict (Psychology);Couples;Development;disorder risk;Distal;Ecological momentary assessment;Emotional;Ensure;Etiology;Event;evidence base;Evidence based treatment;experience;Feeling suicidal;follow up assessment;Future;Goals;high risk;Hour;Hypersensitivity;Impairment;improved;indexing;Individual;Intake;Intervention;Laboratories;Life;Maintenance;Measures;member;Methods;Modeling;multimodality;National Institute of Mental Health;negative affect;non-verbal;novel;Outcome;Participant;Patient Self-Report;Pattern;Persons;Physiological;Physiology;proband;Process;Protocols documentation;Psychophysiology;psychosocial;Public Health;recruit;reducing suicide;Research;resilience;respiratory;response;Risk Factors;Risk Reduction;Sampling;severe mental illness;Severities;Sinus Arrhythmia;Speech;Strategic Planning;suicidal individual;suicidal risk;Suicide;suicide model;Testing;theories;Time;verbal;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Testing a Dyadic Model of Proximal Suicide Risk in Young Adult Romantic Couples

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Mental Health;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT 1 NARRATIVE Early life stress (ELS), or traumatic events during childhood or adolescence, is widespread in the US with ~50% of children and adolescents having one or more major ELS experiences as well as being an independent risk factor for cardiovascular disease. Project 1 utilizes unique mouse models of ELS to determine how ELS initiates and promotes future cardiovascular disease. An in-depth understanding of how ELS promotes cardiovascular disease is essential to reduce the healthcare and economic burden of cardiovascular disease on our society.

PI_NAMEs: POLLOCK, JENNIFER S (contact)

PROJECT_TERMS: 21 year old;Adolescence;Adolescent;Adult;Affect;Age;Anti-Inflammatory Agents;Aorta;arterial stiffness;Blood Pressure;Blood Vessels;Brain;Butyrates;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Child;Childhood;childhood adversity;clinically relevant;Collaborations;Colony-Stimulating Factor Receptors;Data;Development;DNA Damage;early life stress;Economic Burden;Endothelial Cells;endothelial dysfunction;Endothelium;Epigenetic Process;epigenome;experience;experimental study;Exposure to;Functional disorder;Future;Gene Expression;HDAC9 gene;healthcare burden;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;Hypertension;Immune;Immune System Diseases;indexing;Inflammatory;innovation;Kidney;Knock-out;Knockout Mice;Link;Macrophage;Macrophage Activation;Macrophage Colony-Stimulating Factor;maternal separation;Measures;Mediating;Mediator;microbial;Mitochondrial DNA;Molecular;Molecular Profiling;monocyte;mouse model;multiple omics;Mus;NADPH Oxidase;Nitric Oxide;novel;Pathway interactions;Peripheral Resistance;Physiologic pulse;Physiological;Plasma;postnatal;prepuberty;Production;Program Research Project Grants;programs;psychosocial stressors;pup;Receptor Inhibition;Reporting;resilience;Rodent Model;sex;Signal Pathway;Signal Transduction;Societies;Spleen;Superoxides;Supplementation;synergism;System;Testing;timeline;Tissues;transcriptome;Transgenic Mice;Translating;traumatic event;Tunica Adventitia;Vascular Diseases;vascular inflammation;Volatile Fatty Acids;Weaning;Work;young adult

PROJECT_TITLE: Early Life Stress Induced Reprogramming of Vascular Function by the Endothelium and Macrophage Systems


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

PHR: This proposed research is of particular importance to the health of veterans. Veterans are more likely to get Parkinson’s disease (PD) because of links between PD and Agent Orange exposure, repetitive head trauma, and posttraumatic stress disorder. This confluence of factors in an aging veteran population will drive the rising incidence of PD and adversely impact quality of life, for both veterans and their care partners. Through identifying in vivo markers of mitochondrial function, this proposal promises to identify ways to better predict how fast PD will progress, allowing clinicians to better counsel patients and their families on what to expect and when. Another important consequence of being able to better monitor and predict disease progression in PD patients is being able to design more efficient clinical trials, ones that may call for fewer participants and last a shorter duration. This outcome will increase the possibility of finding a drug that helps PD patients sooner, allowing them and their caregivers to more fully participate in their lives and communities.

PI_NAMEs: NEILSON, LEE  (contact)

PROJECT_TERMS: Address;Adenosine Triphosphate;Age;agent orange;Aging;Animals;Area;Autopsy;Bioenergetics;Biological Markers;Bradykinesia;Brain;Brain Diseases;Caregivers;Caring;Clinical;clinical care;clinical practice;clinical predictors;Clinical Trials;Clinical Trials Design;Communities;comparison control;Corpus striatum structure;Counseling;Craniocerebral Trauma;Cross-Sectional Studies;Data;Dementia;design;Diagnosis;Disease;Disease Progression;disorder risk;Exhibits;Family;Foundations;Genetic study;Health;Healthcare;Human;Image;improved;in vivo;Incidence;Individual;innovation;inorganic phosphate;insight;Intervention;Knowledge;Link;magnetic field;magnetic resonance spectroscopic imaging;Magnetic Resonance Spectroscopy;male;malignant phenotype;Measurement;Measures;Methods;Military Personnel;military veteran;Mitochondria;mitochondrial dysfunction;Modeling;Monitor;motor impairment;mRNA Expression;neurocognitive disorder;Neurodegenerative Disorders;neuron loss;Neuronal Injury;Neurotoxins;Nuclear Translocation;Outcome;Parkinson Disease;Participant;patient retention;Patients;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Population;Post-Traumatic Stress Disorders;pre-clinical;precision medicine;predictive marker;Quality of life;Reaction;Research;Rest Tremor;Services;Severity of illness;spectroscopic imaging;Symptoms;Techniques;Testing;Therapeutic;Time;Translating;Translations;Tremor;Veterans;Work

PROJECT_TITLE: Biomarkers of disease severity and progression in Parkinson's


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cost Effectiveness Research;Orphan Drug;Ovarian Cancer;Patient Safety;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: Columbus

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Ovarian cancer is the leading cause of deaths from gynecologic cancers in the U.S. While most women present with advanced disease, more than 1 in 10 of such women will survive >10 years after an initial diagnosis, underscoring the paramount importance of treatment selection. In the proposed research, we will use mathematical modeling techniques to identify personalized treatment approaches – tailored to individual patient and tumor characteristics – that can improve women's chances of long-term survival and minimize their likelihood of receiving harmful, low-value care.

PI_NAMEs: PANDHARIPANDE, PARI VIJAY (contact);WRIGHT, JASON

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: Address;advanced disease;Affect;Aftercare;Age;cancer care;Cancer Etiology;cancer recurrence;cancer survival;cancer therapy;Caring;Cause of Death;Cells;Characteristics;chemotherapy;comorbidity;cost;cost effective;cost effectiveness;cost estimate;Data;Data Sources;Databases;Death Rate;Decision Making;Diagnosis;disease model;Distant;Epithelial ovarian cancer;Future;Goals;Harm Reduction;improved;individual patient;individualized medicine;Knowledge;Life Expectancy;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;mathematical model;Medicare;Modeling;models and simulation;Molecular;Mutation;mutational status;new therapeutic target;Newly Diagnosed;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Outcome;patient stratification;Patients;Periodicals;personalized approach;personalized medicine;Physicians;Policy Maker;Poly(ADP-ribose) Polymerase Inhibitor;prevent;programs;Publishing;Quality-Adjusted Life Years;Recommendation;Recurrence;Research;Research Activity;Research Priority;Resources;Risk;SEER Program;Selection for Treatments;side effect;Survivors;targeted treatment;Techniques;therapy design;Time;Toxic effect;Treatment Failure;Treatment outcome;treatment strategy;Treatment-related toxicity;tumor;Woman;women's diagnosis;Women's mortality;women's outcomes;women's treatment;Work

PROJECT_TITLE: Improving Treatment Selection in Advanced Ovarian Cancer

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Heart Disease;Hypertension;Mental Health;Neurosciences;Nutrition;Prevention;Social Determinants of Health

PHR: PROJECT 2 NARRATIVE The response to hypertension-eliciting stimuli in adults is sensitized by prior exposure to aversive conditions during early life. Evidence indicates that this sensitized response is the result of neuroplasticity in brain pathways controlling the sympathetic nervous system and long-term blood pressure regulation. The proposed studies investigate the mechanisms of postnatal nervous system programming on hypertensive response sensitization.

PI_NAMEs: JOHNSON, ALAN KIM (contact)

PROJECT_TERMS: Acute;Address;Adult;adverse childhood events;Affect;Animals;Anti-Inflammatory Agents;Behavioral;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure regulation;Blood Vessels;Brain;brain pathway;Butyrates;cardiometabolism;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cell Nucleus;Central Nervous System;Cerebrovascular system;Clinical;Collaborations;comparison control;Consumption;cytokine;design;Diet;dietary;Dietary Factors;Dietary Fats;Dietary Intervention;dietary salt;Disease;early life stress;Eating;Epidemiology;Epigenetic Process;Etiology;Exercise;experimental study;Exposure to;Fatty acid glycerol esters;Female;Foundations;Genetic;Glean;high salt diet;Hypertension;hypertensive;Immune system;Individual;Inflammation;Inflammation Mediators;Inflammatory;innovation;insight;Intervention;Investigation;Knowledge;Laboratories;Life;Macrophage;Macrophage Activation;male;maternal separation;Mediating;Mediator;Mental disorders;Methods;Modeling;Molecular;Mothers;Mus;Nervous System;neural network;Neural Pathways;Neuroanatomy;neuroinflammation;Neuronal Plasticity;novel;Oxidative Stress;Pathogenesis;Pathology;Pharmaceutical Preparations;pharmacologic;Physiological;Play;postnatal;pre-clinical;prevent;Process;programs;psychologic;Psychological Stress;psychological stressor;pup;Rattus;Renin-Angiotensin-Aldosterone System;resilience;response;Risk;Risk Factors;Rodent;Rodent Control;Role;Sex Differences;sexual dimorphism;Site;Stimulus;stressor;Sympathetic Nervous System;synergism;Testing;translational pipeline;Vascular Diseases;Weaning;Work

PROJECT_TITLE: Central Nervous System Reprogramming of the Control of Blood Pressure Induced by Early Life Stress


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed study is relevant to public health and precision health because comprehensive evaluation of a wide range of modifiable environmental exposures, including the currently ubiquitous environmental neurotoxicants lead and cadmium, will advance scientific understanding on the etiology of Alzheimer's disease and related dementias (ADRD) and inform individual-level and population-level interventions to effectively prevent or reduce the burden of ADRD. The proposed study is directly responsive to the 2018 National Institute on Aging AD Research Summit recommendations related to Understanding the Impact of the Environment to Advance Disease Prevention and Enabling Precision Medicine Research for AD/ADRD, and to the research goal of NOT-AG-18-053, Enabling precision medicine for AD/ADRD through deep molecular phenotyping.

PI_NAMEs: BAKULSKI, KELLY ;PARK, SUNG KYUN  (contact)

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: abeta deposition;Address;advanced disease;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Animal Model;Behavioral;Biological;Biological Markers;Biology;Blood;bone;Cadmium;Case/Control Studies;Chemicals;chronic Pb exposure;Clinical;clinical phenotype;Cognition;Cohort Studies;Complex;Data;dementia risk;demographics;Development;Diet;Discrimination;disorder prevention;disorder risk;Early Intervention;effective intervention;Environment;environmental chemical;environmental chemical exposure;Environmental Exposure;Environmental Risk Factor;Etiology;Evaluation;Exposure to;follow-up;Future;Genetic;Genotype;Goals;Human;human population study;improved;Individual;Infection;Intervention;Lead;lead exposure;Life Style;Link;machine learning method;Measurement;Measures;Medicare;Modeling;Modernization;modifiable risk;molecular phenotype;multi-ethnic;National Health and Nutrition Examination Survey;National Institute on Aging;Neurodegenerative Disorders;neurotoxic;neurotoxicity;Neurotoxins;novel;Participant;Policies;Population;population based;Precision Health;precision medicine;Predisposition;Prevalence;prevent;Prevention;prospective;Prospective, cohort study;Public Health;Recommendation;Research;Risk;Risk Factors;risk prediction;risk prediction model;Risk Reduction;risk stratification;Role;Scientific Advances and Accomplishments;Strategic Planning;symposium;tau expression;Testing;Time;Toxic Environmental Substances;toxicant;United States;Urine;Vulnerable Populations

PROJECT_TITLE: The Study of the Environment and Alzheimer's disease and related Dementias (SEAD)


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Precision Medicine

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Cancer is the second leading cause of mortality in the United States and disproportionately affects minorities. Clinical research designed and conducted within a consortium of multiple institutions enables faster evaluation of novel therapies, in a variety of malignancies, across different populations nationwide. It also facilitates assessment of scientific correlates that may help assess the effects and individualize cancer therapies.

PI_NAMEs: FLAHERTY, LAWRENCE E (contact);SHIELDS, ANTHONY FRANK

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Adult;Advisory Committees;Affect;American College of Radiology Imaging Network;Biological Markers;Cancer Center;Cancer Research Network;clinical care;Clinical Research;Clinical Trials;Colon Carcinoma;Communities;Comprehensive Cancer Center;Data;Disease;Doctor of Medicine;Doctor of Philosophy;Eastern Cooperative Oncology Group;Enrollment;Evaluation;expectation;Faculty;Funding;Goals;Grant;Healthcare Systems;Image;Institution;Intervention;Intervention Trial;Lead;Leadership;Malignant Neoplasms;Manuscripts;meetings;Melanoma;member;Michigan;Minority;Minority Recruitment;Monitor;mortality;multidisciplinary;National Clinical Trials Network;novel therapeutics;Organ;Parents;participant enrollment;Patient Care;Patient Education;Patients;personalized cancer therapy;Phase;Play;Population;Positioning Attribute;Principal Investigator;programs;Protocols documentation;Publications;Qualifying;Research;Research Design;Role;Safety;Science;Site;Southwest Oncology Group;System;Translations;United States;Universities;Woman

PROJECT_TITLE: NCI National Clinical Trials Network – Network Lead Academic Participating Site


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The overall goal of this project is to increase our collective knowledge on the contribution of vascular and immune components to the pathophysiology of autosomal dominant Alzheimer disease (ADAD), a form of AD with a known genetic etiology involving β-amyloid (Aβ) metabolism, as well as the influence of these components on anti-Aβ therapeutic strategies. This proposal employs multiparametric approaches to assess neurovascular unit disruption using molecular techniques and proteomics, along with magnetic resonance imaging (MRI) for biomarkers of small vessel disease (SVD), imaging measures of cerebral blood flow, and amyloid burden. Determining how these vascular and immune factors impact ADAD pathophysiology and response of individuals to anti-Aβ therapies will greatly further our understanding of the biological mechanisms of this early-onset form of AD and provide insight on potential novel and more targeted therapeutic approaches.

PI_NAMEs: JOSEPH-MATHURIN, NELLY CECILE (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: abeta accumulation;Abeta clearance;Age;age related;Age related comorbidities;age-related disease;Alzheimer's Disease;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;associated symptom;Astrocytes;Atrophic;autosomal dominant Alzheimer's disease;Biological;Biological Markers;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier disruption;Brain;Cardiovascular Diseases;career development;Career Mobility;Cerebral Edema;Cerebral hemisphere hemorrhage;Cerebrovascular Circulation;Cessation of life;Clinical;clinical effect;clinical efficacy;Clinical Research;Clinical Trials;Cognitive;collaborative environment;Dementia;Disease;Disease Marker;Disease Progression;drug development;early onset;Edema;Endothelial Cells;Etiology;Evaluation;Excision;FDA approved;Functional disorder;Genes;Genetic Predisposition to Disease;Goals;Hemorrhage;Image;imaging biomarker;Imaging Techniques;Immune;Immunologic Factors;Impaired cognition;improved;Incidence;Individual;individual response;Inflammatory;Inflammatory Response;innovation;insight;Investigation;Knowledge;Late Onset Alzheimer Disease;Learning;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Mediating;Metabolism;Microvascular Dysfunction;Molecular;Molecular Target;Multimodal Imaging;Mutation;Neuroglia;neuroimaging;Neurons;neurovascular unit;next generation;novel;novel strategies;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Pattern;Pericytes;Pharmaceutical Preparations;pharmacologic;Phase;Play;Population;Positron-Emission Tomography;pre-clinical;Process;protein metabolism;Proteins;proteomic signature;Proteomics;Reporting;Research;Research Personnel;Research Project Grants;response;Role;Safety;Serum;Signal Transduction;skills;success;Symptoms;targeted treatment;Techniques;Therapeutic;Therapeutic Intervention;Training;Treatment outcome;treatment response;Treatment Side Effects;vascular contributions;vascular factor;White Matter Hyperintensity;Work;β-amyloid burden

PROJECT_TITLE: Evaluation of the neurovascular unit in the setting of pathogenesis and treatment of autosomal dominant Alzheimer disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Mental Health;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT 3 NARRATIVE Early life stress is strongly associated with cardiovascular risk and multiple poor health outcomes in adulthood. Adolescence presents an important age window for identifying targets for early interventions that can limit the impact of early life stress on future cardiovascular risk. This proposal seeks to understand the relationships between early life stress and indicators of future cardiovascular disease risk in adolescents, which will provide therapeutic targets for future intervention studies to reduce the public health burden of cardiovascular disease.

PI_NAMEs: SEIFERT, MICHAEL EDWARD (contact)

PROJECT_TERMS: 19 year old;Address;Adolescence;Adolescent;Adult;Affect;Age;Alabama;Animal Model;Aorta;Basic Science;Biological Assay;Blood Pressure;blood pressure variability;Blood Vessels;Brain;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;CD14 gene;Childhood;Clinic;Clinical;cohort;Collaborations;Cross-Sectional Studies;cytokine;Data;data repository;Diastolic blood pressure;Early identification;Early Intervention;early life stress;Enrollment;Epigenetic Process;epigenome;experimental study;Exposure to;Female Adolescents;Functional disorder;Future;Genes;HDAC9 gene;Heart Rate;Household;Human;Hypertension;indexing;Inflammatory;innovation;Intervention Studies;Intervention Trial;Knowledge;life span;Link;Macrophage;Macrophage Colony-Stimulating Factor;Male Adolescents;metabolome;Methylation;methylation pattern;methylome;microbiome;Molecular;monocyte;multiple omics;Mus;neglect;Outcome;pandemic stress;Pathway interactions;Patient Self-Report;Pattern;Persons;Phenotype;Physiologic pulse;Pilot Projects;Plasma;poor health outcome;prevent;protective effect;protective factors;Public Health;Publications;racial diversity;Reporting;Research;Research Design;resilience;Risk;Risk Factors;Role;Salivary;Sampling;secondary analysis;synergism;Testing;therapeutic target;transcriptome;Vascular Diseases;Vascular Endothelium;Volatile Fatty Acids;Work

PROJECT_TITLE: Early Life Stress-induced Reprogramming of Ambulatory Blood Pressure and Vascular Function in Adolescence


ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Dr. Cooper is a world leading rehabilitation engineer. He is a US Army veteran with spinal cord injuries who has dedicated his career to helping veterans to lead full and rewarding lives through engineering and advancing assistive technology. He has made broad contributions to science, engineering, and education applied to improving the quality of life of veterans with disabilities, and providing opportunities to become scientists and engineers. His research activities focus on the design, engineering, and evaluation of mobility devices, robots, and other systems for veterans with disabilities. Dr. Cooper is Director of the VA Rehabilitation Research & Development Center for Wheelchairs and Assistive Robotics, and a VA Senior Research Career Scientist. He has built research collaborations and provided training to >4,000 clinicians/scientists. His work has resulted in four books, >30 patents awarded/pending, and >100 inventions/innovations. His work engages veterans from concept to deployment.

PI_NAMEs: COOPER, RORY A. (contact)

PROJECT_TERMS: Academia;Academy;Algorithms;American;American Association for the Advancement of Science;Amputees;Amyotrophic Lateral Sclerosis;Archives;Asia;assistive robot;Australia;Automobile Driving;Award;Beds;Biomedical Engineering;Books;career;career development;Caring;Clinical Practice Guideline;Collaborations;combat;Commercial Sectors;Compensation;Complex;conditioning;Consensus;Dedications;Department of Defense;design;Devices;disability;Disability research;Disabled Persons;diversity and inclusion;Doctor of Philosophy;editorial;Education;Electronics;Engineering;Europe;Evaluation;Foundations;Funding;Government;Grant;Grant Review;handbook;Health;Healthcare;Impairment;improved;improved mobility;Independent Living;indexing;Industry;innovation;International;invention;Journals;Joystick;knowledge translation;Language;Lead;lectures;Legal patent;Licensing;Lifting;limb amputation;Lower Extremity;Manual wheelchair;Medal;Medical;Medicare/Medicaid;member;Mentors;Methods;Military Personnel;mobility aid;Multiple Sclerosis;Neurofibromin 2;New Zealand;North America;older adult;Paper;Peer Review;Pennsylvania;Persons;Physical Efforts;Physical Medicine;Physical Rehabilitation;Physics;Policies;Positioning Attribute;Postdoctoral Fellow;Powered wheelchair;preservation;Principal Investigator;Professional Organizations;programs;Prosthesis;prototype;Provider;Publications;Publishing;Quality of life;rehabilitation engineering;rehabilitation research;Rehabilitation therapy;Reporting;Research;Research Activity;research and development;Research Training;Rewards;Robot;Robotics;Science;Scientist;Self-Help Devices;Services;Shapes;Societies;South America;Spinal cord injury;Sports;Students;symposium;System;Technology;Technology Transfer;Training;Translating;Transportation;United States National Institutes of Health;Universities;Upper Extremity;USAID;Veterans;Voice;Wheelchair user;Wheelchairs;Work;World Health Organization

PROJECT_TITLE: RR&D Research Career Scientist Award Application

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Mental Health;Mental Illness;Neurosciences;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: The goal of the proposed research is to test the role of interactions between brain stress and brain reward circuits in mediating behavioral dysregulation during alcohol withdrawal. The proposed experiments will test the effects of chronic alcohol on specific brain reward and brain stress circuits, and the role of those circuits in mediating alcohol withdrawal-induced increases in anxiety-like behavior. The results of this work will advance our understanding of the neurobiology underlying alcohol use disorder (AUD) and may identify new targets for treating AUD in humans.

PI_NAMEs: AVEGNO, ELIZABETH MINOR (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Abstinence;Acute;addiction;Addictive Behavior;Address;Adult;Affect;Affective Symptoms;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol research;alcohol response;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;American;Amygdaloid structure;Anatomy;Animals;Anxiety;anxiety-like behavior;Area;Behavior;Behavioral;Brain;Brain region;Calcium Signaling;Cannabinoids;career;Cessation of life;Chronic;CNR1 gene;cost;Data;Dependence;Depressed mood;Development;Disease;Disinhibition;Dopamine;dopaminergic neuron;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;experience;experimental study;Female;Fiber;Gene Expression;Genetic;Goals;Health;Human;hypocretin;Image;improved;In Vitro;in vivo;Individual;individual response;Inhalation;Investigation;knock-down;male;Mediating;Molecular Biology;Morbidity - disease rate;Mus;negative affect;neural;neuroadaptation;neurobiological mechanism;Neurobiology;Neurons;Neuropeptides;Neurosciences;neurotransmission;orexin 1 receptor;pharmacologic;Pharmacology;Photometry;Physiology;presynaptic;Quality of life;Rattus;Receptor Activation;receptor expression;recruit;Relapse;Research;Research Training;Rewards;Role;Scientist;skills;Slice;Stress;System;Techniques;Testing;therapeutically effective;therapy development;Training;treatment strategy;United States;vapor;Ventral Tegmental Area;Viral;Withdrawal;withdrawal-induced anxiety;Work

PROJECT_TITLE: Orexin modulation of brain reward-brain stress system interactions in alcohol withdrawal anxiety

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: MEMPHIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: PUBLIC HEALTH RELEVANCE: Aspergillosis is associated with high morbidity and mortality among immunocompromised patient populations. The recent emergence of antifungal resistance in Aspergillus is threatening our already limited therapeutic armamentarium for this disease and represents a major impediment to effective treatment. It is of vital importance to understand how resistance develops in Aspergillus, so that this knowledge can be translated into therapies that prolongs the lives of affected individuals.

PI_NAMEs: FORTWENDEL, JARROD R. (contact);ROGERS, P. DAVID

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Address;Affect;Alleles;Anabolism;anti-fungal agents;Antifungal Therapy;Aspergillosis;Aspergillus;Aspergillus fumigatus;Automobile Driving;Azole resistance;Azoles;Clinical;clinical predictors;clinically relevant;Collection;Complex;Coupled;CRISPR/Cas technology;Data;Death Rate;Diagnosis;differential expression;Diffusion;Disease;DNA Sequence Alteration;Drug Transport;effective therapy;Ensure;enzyme biosynthesis;Ergosterol;Evolution;Exhibits;experimental study;Fungal Drug Resistance;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;genetic analysis;genetic manipulation;Genome;genome analysis;Genomics;Goals;human pathogen;Immunocompromised Host;improved;In Vitro;Individual;Infection;inhibitor;innovation;insight;Knowledge;Laboratories;Mediating;Methods;Molds;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;mutant;Mutation;novel;novel strategies;Outcome;overexpression;Oxidoreductase;Pathway interactions;patient population;Play;Predisposition;prevent;Proteins;public health relevance;Regulation;Research;Resistance;Resistance development;resistance mechanism;resistance mutation;Resistance profile;resistant Aspergillus;Risk;Role;Sequence Analysis;stem;Sterol Biosynthesis Pathway;Sterols;System;Techniques;Testing;Therapeutic;Transcriptional Activation;Translating;treatment choice;Treatment Failure;Voriconazole;whole genome;Work

PROJECT_TITLE: Non-cyp51A-mutation Mediated Triazole Resistance in Aspergillus fumigatus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-S(02)]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

ORG_CITY: BROOKINGS

ORG_NAME: SOUTH DAKOTA STATE UNIVERSITY

ORG_STATE: SD

PI_NAMEs: IMRE, GERGELY  (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: CASP1 gene;CASP2 gene;Caspase;Cell Death;Cell membrane;Cell Survival;Communicable Diseases;Complex;cytokine;Data;Endosomes;Family;immune activation;Infection;Inflammasome;Inflammation;Inflammatory;innovation;insight;Lead;member;Membrane;Molecular;Names;novel;pathogen;Pathogen detection;Peptide Hydrolases;Prevention approach;protein complex;Proteins;Regulation;repaired;Research;response;sensor;Signal Transduction;Sorting;System;Testing;Toxin;Translational Research;Work

PROJECT_TITLE: Identification of the molecular regulation between cell survival and cell death in response to infection induced inflammasome activation.


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Kidney Disease

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative Despite the increasing prevalence of kidney diseases, there is a shortage of nephrology workforce to advance scientific discoveries and technology to address the growing burden of kidney diseases. The lack of innovation and kidney technology development over the past decades has been a primary barrier to breakthroughs in the field. The VA K-TUTOR program will provide a rich environment to excite and recruit young talent to foster innovative solutions to benefit the 40 M people in the US with kidney diseases. The VA K-TUTOR will be a partnership of UVA Division of Nephrology, UVA schools of Engineering and Arts and Sciences, College of Arts and Sciences and VA Tech School of Medicine to recruit and train undergraduate students for identifying problems in kidney research and finding novel solutions.

PI_NAMEs: GUILFORD, WILLIAM H;OKUSA, MARK DOUGLAS;SHARMA, RAHUL  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acceleration;Address;Adult;Advanced Development;Aging;American;Applied Research;Arts;Awareness;Biomedical Engineering;career;career development;Childhood;Clinical;Clinical Trials;Collaborations;college;Coupled;Data Science;design;Discipline;Education Projects;education research;Engineering;Ensure;Entrepreneurship;Environment;experience;Exposure to;Faculty;Fostering;Functional disorder;Funding;Generations;Goals;graduate school;Growth;Human;Immersion;Immunity;improved;Industry;Inflammation;innovation;Intellectual Property;interest;Kidney;Kidney Diseases;Lead;Learning;medical schools;Mentors;Modeling;multidisciplinary;Nephrology;next generation;novel;novel therapeutics;Patients;Persons;Phase;Physiology;Positioning Attribute;Prevalence;Prize;Program Development;programs;public-private partnership;recruit;Regenerative Medicine;Reporting;Research;research and development;Research Institute;Research Personnel;Research Training;Schools;Science;Scientific Advances and Accomplishments;Societies;Students;summer program;summer research;Talents;Technology;technology development;technology research and development;Training;Training and Education;translational health science;trend;undergraduate student;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;university student;Virginia

PROJECT_TITLE: The University of Virginia Kidney Technology Development Research Education Program (VA K-TUTOR)

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eating Disorders;Mental Health;Neurosciences;Nutrition;Obesity

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Obesity is a serious health problem affecting more than one-third of adults in the United States that is generally caused by excessive food intake. The proposed research is relevant to public health because it will identify and characterize the evolutionarily conserved brain circuits involved in appetite control, which will enable the development of novel therapies to treat obesity and other feeding related diseases such as eating disorders.

PI_NAMEs: CAI, HAIJIANG  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Adult;Affect;Amygdaloid structure;Anorexia;anorexic;Appetite Regulation;Area;Attenuated;Body Weight;Brain;Brain region;Cell Nucleus;Cholecystokinin;Data;Desire for food;Development;Disease;Disinhibition;Disparate;Eating;Eating Disorders;effective therapy;Fasting;feeding;Feeding behaviors;gamma-Aminobutyric Acid;Gastrointestinal tract structure;Genetic;Genetic Markers;Goals;Health;inhibitory neuron;innovation;Knowledge;Label;Maps;Mediating;Methods;neural;neural circuit;Neural Pathways;neuromechanism;Neurons;novel;novel strategies;novel therapeutics;Obesity;obesity treatment;Outcome;Peptides;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Play;Population;protein expression;protein kinase C-delta;Public Health;receptor;Regulation;Research;Role;Satiation;Structure;Synapses;Testing;therapy development;tool;United States;Vagus nerve structure

PROJECT_TITLE: Dissecting a central amygdala-parasubthalamic nucleus circuitry underlying appetite control

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Mental Health;Microbiome;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT 4 NARRATIVE Early life stress is an important risk factor for cardiovascular disease, but the biological mechanisms of these effects are not clear, nor is it known whether lifestyle factors during development diminish the negative impact of early life stress on cardiovascular outcomes. This project investigates the roles of gene expression, inflammation, and gut microbiome in the connections between early life stress, lifestyle/psychosocial factors, and vascular function in adulthood.

PI_NAMEs: MRUG, SYLVIE  (contact)

PROJECT_TERMS: Adolescence;Adolescent;Adult;Adverse event;Age;Alabama;American;Animal Model;Animals;Aorta;Biological;Blood Pressure;blood pressure variability;Blood Vessels;C-reactive protein;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Child Rearing;cohort;Colony-Stimulating Factors;critical developmental period;cytokine;Data;Development;Diet;early experience;early life stress;ethnic diversity;Evaluation;Evidence based intervention;experience;Exposure to;Future;Gene Expression;Genetic Transcription;gut microbiome;HDAC9 gene;Heart Rate;Histone Deacetylase;Human;Hypertension;Immune;Immune system;Immune System Diseases;indexing;Individual;Inflammation;Inflammatory;inflammatory marker;innovation;Interleukins;Intervention;Knowledge;Lead;Life Style;lifestyle factors;Link;Macrophage Colony-Stimulating Factor;Measures;Mediating;Mediation;metabolome;metabolomics;Methylation;methylome;microbiome;microbiome composition;Modeling;Molecular;multiple omics;NADPH Oxidase;novel;Outcome;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Physical activity;Physiological;prevent;prospective;protective factors;Psychosocial Factor;resilience;Risk Factors;Rodent;Rodent Model;Role;Stress;synergism;Testing;Time;Tissue-Specific Gene Expression;TNF gene;transcriptome;Up-Regulation;Vascular Diseases;Vascular System;Volatile Fatty Acids;young adult

PROJECT_TITLE: Prospective Effects of Early Life Stress and Protective Factors on Vascular Function and Inflammation in Young Adulthood


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MONTREAL

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF MONTREAL

ORG_STATE: PQ

ORG_ZIPCODE: H3C 3J7

PHR: Project Narrative The protein, eIF4E, is important to normal cells and when dysregulated can drive the development of a broad array of cancers. eIF4E does this by co-opting the signal from the DNA (known as RNA) allowing it to generate more of the proteins that can drive cancer. In this proposal, we identified a new mechanism by which eIF4E uses this activity to imbue cancer cells with the ability to move, and thus invade neighboring tissue. We can exploit this new knowledge to ultimately develop new therapeutic strategies for high-eIF4E cancers.

PI_NAMEs: BORDEN, KATHERINE L B (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Actins;Acute monocytic leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adherence;Anti-viral Agents;Binding;Binding Sites;Biochemical;Biological;Bone Marrow;cancer cell;Cancer Patient;CD44 Antigens;CD44 gene;Cell Line;Cell membrane;cell motility;Cells;Clinic;Complex;Cytoskeleton;Development;Disease;Disease remission;DNA;Encapsulated;Engraftment;Eukaryotic Initiation Factors;Event;Extramedullary;ezrin;Genetic;Glycosaminoglycans;Head and Neck Cancer;Homing;Hyaluronan;Impairment;In Vitro;in vivo;Invaded;Knowledge;leukemia;Link;link protein;Liver;lymph nodes;Malignant Neoplasms;Mechanics;Membrane;migration;Molecular;Monitor;Morphology;Motility;mouse model;Neoplasm Metastasis;neoplastic cell;Newly Diagnosed;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Nuclear Export;Nuclear RNA;Oncogenic;Outcome;overexpression;Patients;pharmacologic;Phase I Clinical Trials;Phosphorylation;Physiological;Process;Production;programs;Proliferating;Property;Prostate;protein function;Proteins;receptor;Regulon;response;Ribavirin;RNA;RNA Caps;RNA Processing;Role;Signal Transduction;Site;Solid;Specimen;Spleen;Surveys;Therapeutically Targetable;Tissues;Transcript;Translations;tumor

PROJECT_TITLE: Oncogenic impact of eIF4E-dependent RNA export in cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Project Narrative Non-malarial acute undifferentiated febrile illnesses (AUFIs) continue to be significant causes of morbidity and mortality in Latin America, and the lack of definition of the underlying etiologies and involved vectors has prevented the development of appropriate public health interventions. Over the past five years, we completed advanced training of Colombian Faculty members, PhD students and postdoctoral fellows. We will implement new strategies as we continue to build capacity and train investigators from six collaborating institutions in Colombia to address these important and frequently lethal diseases.

PI_NAMEs: AGUILAR, PATRICIA VERONICA (contact);RODAS, JUAN DAVID

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: 2019-nCoV;Acute;Address;authority;Awareness;Bioethics;Bioinformatics;Colombia;Colombian;Country;Dengue;design;Diagnosis;Diagnostic Procedure;Disease;Doctor of Philosophy;doctoral student;Educational workshop;Electron Microscopy;Enrollment;Ensure;Ethics;expectation;Faculty;Fever;Funding;Goals;Grant;Health Personnel;Health Professional;Human;Incidence;Infectious Diseases Research;influenzavirus;Institution;interest;Laboratories;Latin America;Leadership;low and middle-income countries;Manuscripts;member;Mentorship;Methodology;Methods;Molecular;Morbidity - disease rate;mortality;novel;novel diagnostics;Outcome;pathogen;Postdoctoral Fellow;pre-doctoral;Preparation;programs;Progress Reports;Public Health;recruit;Research;Research Methodology;Research Training;respiratory virus;Science;Scientist;Students;Testing;Trainers Training;Training;Training Programs;Training Support;Undifferentiated;Vector-transmitted infectious disease;Visit;Writing;Zoonoses

PROJECT_TITLE: Colombia-U.S. Fogarty training program on the impact of emerging zoonotic and vector-borne diseases in acute undifferentiated febrile illnesses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Z(55)R]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Endocrine Disruptors;Estrogen;Genetics;Mental Health;Neurosciences;Pediatric

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Humans are ubiquitously exposed to endocrine-disrupting chemicals (EDCs) in the environment; among these, polychlorinated biphenyls (PCBs) strongly affect hormone-sensitive developmental processes and are associated with a wide-range of adverse neurobiological health outcomes in humans and wildlife. Understanding the underlying mechanisms of PCBs on neural development across generations, and how these exposures can alter future behavior, can inform medical interventions and guide public health policy. In my proposal a rat model of perinatal PCB exposure relevant to humans is used to explore the phenotype of neurobehavioral disorders and the molecular and epigenetic processes that underlie them in exposed individuals and their offspring.

PI_NAMEs: HILZ, EMILY NICOLE (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;Adult;adverse outcome;Affect;Affective;Animal Model;Attention;Attention deficit hyperactivity disorder;Behavior;Behavior Disorders;behavior test;Behavioral;behavioral outcome;behavioral phenotyping;Biological Process;bisulfite sequencing;Brain;brain tissue;career development;Chemical Actions;Chemical Exposure;Chemical Models;Cognition Disorders;Cognitive;Cognitive deficits;Corpus striatum structure;critical developmental period;Development;Developmental Process;Disease;DNA;DNA Methylation;Dopamine;Dopamine Receptor;dopamine system;dopamine transporter;Embryonic Development;Endocrine;Endocrine disruption;Endocrine Disruptors;Environment;epidemiologic data;Epigenetic Process;epigenetic regulation;Estradiol;estrogen disruption;Estrogen Receptors;estrogenic;Estrogens;experience;exposed human population;Exposure to;Female;fetal;Fetus;Future;Gene Expression;gene function;Generations;Genes;Genome;Germ Cells;Germ Lines;Goals;Gonadal structure;Health;Health Policy;hormonal signals;Hormones;Human;Immunohistochemistry;Impaired cognition;Impairment;In Situ Hybridization;Individual;intergenerational;Intervention;Knowledge;Learning;Life;Life Cycle Stages;Link;male;Mediating;Medical;Mental disorders;Mentorship;methylation pattern;Midbrain structure;Modeling;Molecular;Moods;Mus;National Institute of Environmental Health Sciences;neural;Neuroanatomy;neurobehavioral;neurobehavioral disorder;Neurobiology;neurodevelopment;Neurons;Neurosecretory Systems;nonhuman primate;offspring;Organism;Outcome;Ovum;Pathway interactions;Perinatal;Perinatal Exposure;Phenotype;Polychlorinated Biphenyls;preference;Prefrontal Cortex;Pregnancy;primary outcome;Process;programs;protein expression;Proteins;Public Health;Rattus;Receptor Gene;Reproductive Behavior;Research;response;reward processing;Rewards;RNA;sex;sex as a biological variable;Sex Bias;Signal Transduction;Social Behavior;sperm cell;Structure;System;Techniques;Testing;Time;Training;training opportunity;Work

PROJECT_TITLE: Endocrine Disruption of the Developing Dopamine System


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Immunotherapy;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The immune system plays a critical role in eliminating cancer cells. We have data showing that inhibition of Galectin-1, a hypoxia and radiation regulated protein, leads to a significant decrease in immune suppressive immature myeloid cells (MDSC) in the tumor and blood of tumor bearing mice. Therefore, we posit that Galectin- 1 can enhance the expansion of MDSC in the circulation and attract them to the tumor after radiation, where they exert a negative effect on T cells. We also postulate that targeting MDSC with CXCR2 inhibitor in combination with radiotherapy and PD1 immune checkpoint therapy will overcome the deleterious effect of Galectin-1.

PI_NAMEs: LE, QUYNH-THU XUAN (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Affect;Algorithms;angiogenesis;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;Antibodies;Blocking Antibodies;Blood;cancer cell;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;checkpoint therapy;chemokine;chemoradiation;Chemotactic Factors;Circulation;Clinical;comparative efficacy;CXCL1 gene;CXCL2 gene;Data;Distant Metastasis;Endothelium;Exclusion;Fractionated radiotherapy;Galectin 1;Genetic;Growth;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;HPV negative;HPV positive;Human;Hypoxia;IL8RB gene;Immune;Immune system;Immunosuppression;improved;inhibitor;Link;Literature;Lung;malignant mouth neoplasm;Malignant Neoplasms;Measures;Mediating;Mediator;Metastatic Neoplasm to the Lung;migration;Modeling;mouse model;Mus;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;novel therapeutics;overexpression;Pathway interactions;Patients;Peripheral;Phenotype;Play;Primary Neoplasm;Prognosis;programmed cell death protein 1;Progression-Free Survivals;Proteins;Radiation;Radiation therapy;RANTES;recruit;response;Role;Shapes;Site;small molecule inhibitor;Stains;success;System;T-Cell Depletion;T-Lymphocyte;Testing;Translating;Treatment Failure;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Tumor-Derived

PROJECT_TITLE: The role of Galectin-1 in shaping the immune suppressive landscape in head and neck cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: NARRATIVE Fragile X syndrome (FXS) is a devastating neurodevelopmental disorder with prominent sensory hypersensitivity that negatively impact the quality of life of individuals. These studies will determine how the formation and function of brain circuits that underlie this are disrupted in a mouse model of FXS. Ultimately, our translational studies in mice will test new classes of treatments to alleviate sensory symptoms in FXS.

PI_NAMEs: CONTRACTOR, ANIS ;PORTERA-CAILLIAU, CARLOS  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Acute;Adaptive Behaviors;Address;Adult;Affect;Animal Model;Animals;Apoptosis;autism spectrum disorder;avoidance behavior;Behavior;Biological Assay;Birth;Brain;Bromodeoxyuridine;Calcium;Caspase;Cell Death;Cell Density;cell type;Cells;Cessation of life;Characteristics;Chronic;Collaborations;Contractor;critical period;Data;Date of birth;density;designer receptors exclusively activated by designer drugs;Development;Drug Modulation;efficacy evaluation;Experimental Designs;Fragile X Syndrome;Functional disorder;Genes;Genetic;Goals;Grant;hippocampal pyramidal neuron;Hypersensitivity;Image;Impairment;In Vitro;in vivo;in vivo calcium imaging;Individual;Intellectual functioning disability;interdisciplinary approach;Interneurons;Knockout Mice;Laboratories;loss of function;Maps;mature animal;Medial;migration;mouse model;Mus;nerve stem cell;Neuroanatomy;Neurodevelopmental Disorder;neurogenesis;Neurologic Symptoms;neuronal excitability;Neurons;novel;Parvalbumins;patch clamp;Perceptual learning;Phenocopy;Phenotype;postmitotic;postnatal;Pyramidal Cells;Quality of life;Reporting;response;Sensory;Slice;small molecule;Somatosensory Cortex;Somatostatin;Symptoms;Tactile;Testing;Therapeutic;therapeutic target;tool;translational study;two-photon;Universities;Vibrissae;Work

PROJECT_TITLE: Cortical Interneuron Dysfunction in Fragile X Syndrome

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Disability Research;Health Services;Infant Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE  When preterm birth occurs at the most extreme youngest gestation, the hope of neurologically intact survival must be weighed against the very severe trauma that infants and families may undergo in efforts to resuscitate and care for an infant that may ultimately have a very short life or severe life-long disability.  Clinicians lack the ability to provide the most accurate and up-to-date information to the family so that they can come to the best decision for the infant, as current prediction models rely on older data, are not tailored to the individual institution where the birth is occurring, and use limited information to make predictions; furthermore, there is a gap in knowledge in the following: how the use of prediction tools might impact counseling and clinical practice; whether tools can make any difference in outcomes such as survival without morbidity and length of stay before death; and the cost impact and cost-effectiveness of using such tools.  We propose to expand the knowledge base on prediction models for periviable gestation in an existing network of neonatal intensive care units in California – involving 140 hospitals from which to obtain data—by implementing the prediction model with established collaborative quality improvement methods, evaluating the impact of implementation on practices and outcomes, and examining the cost impact of implementation in clinical practice.

PI_NAMEs: LEE, HENRY CHONG (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: 2 year old;Address;anxious;Behavior;Birth;California;Cessation of life;Clinic;Clinical;clinical care;clinical decision-making;clinical practice;cohort;Communities;cost;Cost Analysis;cost effectiveness;Cost Effectiveness Analysis;cost estimate;Counseling;Data;Data Aggregation;Data Collection;data infrastructure;data platform;Decision Making;Delivery Rooms;demographics;disability;electronic data;falls;Family;fetal;fetal diagnosis;follow-up;Gestational Age;hospital care;Hospitals;improved;improved outcome;Individual;Infant;Infant Care;innovation;Institution;Knowledge;knowledge base;Lead;Length of Stay;Life;Lifelong disability;Link;Methods;model building;Modeling;Modernization;Morbidity - disease rate;mortality;Mothers;National Institute of Child Health and Human Development;Neonatal;Neonatal Intensive Care Units;neonate;Neurodevelopmental Disability;Neurodevelopmental Impairment;Neurologic;Outcome;Outcome Study;Palliative Care;Patients;Performance;Perinatal;periviable;Population;population based;predict clinical outcome;predictive modeling;predictive tools;Pregnancy;Premature Birth;Prognosis;prognostic;Quality of Care;Randomized;Research;Resources;respiratory;Resuscitation;risk prediction;risk prediction model;Source;Survivors;Testing;Time;tool;Trauma;Uncertainty;Use Effectiveness;Variant

PROJECT_TITLE: Improving outcomes of periviable births via an enhanced prediction tool

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: Overall Component This application would initiate a Center of Biomedical Research Excellence (COBRE) in Omaha, Nebraska, with a focus on human neuroscience research across the lifespan. The Cognitive Neuroscience of Development and Aging (CONDA) Center would include an administrative core that oversees a dynamic collection of supporting programs, an advanced Neuroimaging Acquisition and Analysis Core Facility, four primary COBRE junior research projects led by NIH-defined early-stage investigators, and an established cohort of senior investigators. The Center would be based at the University of Nebraska Medical Center (UNMC), but its programs and supported members would extend across four centrally-located academic campuses in downtown Omaha, and its impact would be felt across the region.

PI_NAMEs: DUNAEVSKY, ANNA  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Acceleration;Address;Advisory Committees;affective neuroscience;Aging;Area;Award;boys;Brain;brain research;career development;Centers of Research Excellence;Clinical;Cognitive;cognitive development;cognitive neuroscience;cohort;Collection;Communities;Core Facility;Dedications;design;Development;Diabetes Mellitus;Discipline;Disease;Educational workshop;Ensure;Environment;Equipment;Evaluation;Event;experience;Extramural Activities;Faculty;Fellowship;Fellowship Program;Financial Support;frontier;Funding;Future;Future Generations;Future Teacher;Goals;Government;graduate student;Grant;Growth;Hospitals;Human;improved;Infrastructure;innovation;Institution;interest;Internships;Journals;Laboratories;Lead;life span;Location;Magnetic Resonance Imaging;Medical center;member;Mentors;Methods;Midwestern United States;Modality;Monitor;multidisciplinary;National Institute of General Medical Sciences;Nebraska;neuroimaging;Neurologic;neuroregulation;Neurosciences;Neurosciences Research;novel;operation;Participant;Pilot Projects;Postdoctoral Fellow;programs;Publishing;recruit;Registries;Research;research and development;Research Personnel;Research Project Grants;Research Support;Resources;scaffold;Scholars Program;Scientist;Series;Site;Stretching;Structure;Support System;System;tool;Training;training opportunity;United States National Institutes of Health;Universities;Voice;Work


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PROJECT_TERMS: Achievement;Address;Administrator;Advisory Committees;Aging;Area;Assessment tool;Award;Awareness;boys;Brain;career;career development;Centers of Research Excellence;Cognitive;cognitive ability;cognitive neuroscience;Collaborations;Collection;Communities;community engagement;Core Facility;design;Development;Development Plans;Doctor of Philosophy;Education;Educational workshop;Elderly;Ensure;Equipment;Evaluation;Event;experience;Extramural Activities;Faculty;Feedback;Fellowship;Fellowship Program;Fostering;Funding;Funding Mechanisms;Goals;graduate student;Grant;Growth;Hospitals;Human;Human Resources;Image;Individual;Infrastructure;innovation;interest;International;Internships;Investments;Laboratories;life span;Medical center;member;Mentors;mid-career faculty;Midwestern United States;Monitor;National Institute of General Medical Sciences;Nebraska;neuroimaging;neuroregulation;Neurosciences;Neurosciences Research;next generation;outreach program;Participant;Phase;Pilot Projects;Population;Positioning Attribute;Postdoctoral Fellow;programs;Publishing;recruit;Registries;Reporting;Research;research and development;research faculty;Research Personnel;Research Project Grants;Research Support;Resources;scaffold;Scholars Program;Science;Scientist;Senior Scientist;Series;Solid;Stretching;Structure;Students;Support System;symposium;Training;training opportunity;undergraduate student;United States National Institutes of Health;Universities;Work;Youth

PROJECT_TITLE: Training, Evaluation, Engagement, Administration, and Mentoring (TEEAM) Core


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Digestive Diseases;Health Services;Inflammatory Bowel Disease;Patient Safety;Prevention

ORG_CITY: SCANDIA

ORG_NAME: FISTULA SOLUTION CORPORATION

ORG_STATE: MN

PHR: Project Narrative More than 100,000 patients undergo surgery to create a stoma (an opening in the abdominal wall) for treatment of intestinal disease or injury each year in the United States. To decrease the risk of complications, we have developed the LimpetTM, a new device designed as an alternative to conventional pouches used to collect waste from the stoma. Our goal is to deliver a new post-surgical standard of care to improve ostomy patient outcomes, shorten hospital stays, reduce readmissions, and save healthcare costs.

PI_NAMEs: OBST, ANDREW T (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Abdomen;abdominal wall;Accidents;Adhesives;Age;Agreement;biomaterial compatibility;Blood flow;Body mass index;Clinical;Clinical Trials;clinically significant;Colon Carcinoma;Colorectal Cancer;commercialization;cost;Crohn's disease;Data;design;design verification;Device Designs;Device Safety;Devices;Diverticulitis;Edema;efficacy testing;Ensure;experience;Feces;Fistula;Goals;Hand;healing;Health;Health Benefit;Health Care Costs;Healthcare Systems;high body mass index;Home;hospital readmission;Hospitals;Human;improved;Inflammatory Bowel Diseases;Injury;innovation;International;Intestinal Diseases;intestinal injury;Intestinal Obstruction;Intestines;Leaky Gut;Length of Stay;Life;Liquid substance;Manuals;manufacturability;manufacture;manufacturing capabilities;manufacturing process;manufacturing test;Medical;military service;Minnesota;novel;Operative Surgical Procedures;Ostomy;Outcome;Patient Discharge;patient safety;Patient-Focused Outcomes;Patients;Pelvis;Performance;Phase;Population;pressure;prevent;Procedures;Process;Production;Prosthesis;Randomized, Controlled Trials;Rectal Cancer;repaired;Reporting;Research;Risk;Safety;seal;Secure;Skin;skin damage;Small Business Innovation Research Grant;standard of care;Standardization;Sterility;Stomas;Surgical incisions;Surgical sutures;Swelling;Technology;Testing;Therapeutic;tissue oxygenation;Tissues;Trauma;trial comparing;Ulcerative Colitis;United States;United States Centers for Medicare and Medicaid Services;Vacuum;wasting;Work;wound care

PROJECT_TITLE: Novel Post-surgical Incision Management Device to Prevent Ostomy Complications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(10)]


ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE This research program aims to elucidate the fundamental molecular mechanisms of channelrhodopsins, a family of microbial proteins similar to visual pigments that enable control of neurons and cardiomyocyte cells with light by combined optical and genetic techniques (“optogenetics”). Channelrhodopsins have been used to map brain circuitry, as well as for experimental therapeutics, and clinical trials are underway to use channelrhodopsins to restore vision to blind individuals. Molecular understanding of their mechanisms will enable engineering optogenetic tools that will benefit biomedical research and potentially treatment of neurological and cardiac diseases, such as epilepsy, Parkinson's disease, neuropathic pain, and tachycardia and other heart rhythm disorders.

PI_NAMEs: SPUDICH, JOHN LEE (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Action Potentials;Algae;Anions;Basic Science;Biomedical Research;brain circuitry;Brain Mapping;Cardiac Myocytes;Cations;Cell membrane;Cells;Chlamydomonas reinhardtii;Clinical Trials;Color;constriction;Coupled;Cryoelectron Microscopy;Darkness;Disease;Distant;Electrophysiology (science);Engineering;Epilepsy;Family;Genetic Techniques;Genome;Heart Diseases;heart rhythm;Image;In Vitro;in vivo;inhibitor;innovation;Investigational Therapies;Ion Channel Gating;Ions;Kinetics;Knowledge;Laboratories;Learning;Light;light gated;microbial;Microbial Rhodopsins;Mining;Molecular;Molecular Conformation;Mutagenesis;Nervous System Disorder;neural circuit;Neurons;Neurosciences Research;Optics;optogenetics;painful neuropathy;Parkinson Disease;Pathway interactions;Penetration;photoactivation;Physiological;programs;Proteins;receptor;redshift;Research;Resources;response;Retinal Pigments;Rhodopsin;Role;Seminal;sight restoration;Spectrum Analysis;Structure;Tachycardia;Techniques;Technology;Tissues;tool;Visually Impaired Persons;Work;X-Ray Crystallography

PROJECT_TITLE: Structure/Function of Channelrhodopsins and Related Retinylidene Proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(07)R]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences

PROJECT_TERMS: Acceleration;Aging;Award;boys;Brain;brain research;Centers of Research Excellence;Cephalic;cognitive ability;Cognitive aging;cognitive development;cognitive neuroscience;cognitive testing;Collection;Communities;Computer software;computerized data processing;computing resources;Core Facility;Data;data acquisition;Data Analyses;Data Analytics;Dedications;density;Development;Diffusion;Doctor of Philosophy;Educational workshop;Electroencephalography;Elements;Ensure;Equipment;Event;experience;experimental study;Extramural Activities;Faculty;Foundations;functional near infrared spectroscopy;Funding;Future;Goals;Grant;Growth;Head;High Performance Computing;Home;Hospitals;Human;improved;Infrastructure;innovation;Institution;Instruction;instrumentation;International;Laboratories;Leadership;Magnetic Resonance Imaging;Magnetism;Magnetoencephalography;Medical center;member;Mentors;method development;Methods;mid-career faculty;Mission;Modality;multimodal fusion;Multimodal Imaging;multimodality;Nebraska;neural;neuroimaging;Neuronavigation;neuroregulation;Neurosciences;Neurosciences Research;novel;Output;Participant;Performance;Perfusion;Phase;Pilot Projects;Play;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;primary outcome;prisma;Process;Productivity;programs;Publications;Publishing;Research;research and development;Research Personnel;Research Project Grants;Resources;Role;Science;Scientist;sensor;skills;Spectrum Analysis;Statistical Models;Stretching;Structure;System;Technical Expertise;tool;Training;Training Programs;Transcranial magnetic stimulation;translational neuroscience;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Neuroimaging Acquisition and Analysis Core


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Genetics

ORG_CITY: LEXINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Living stock resources are needed for the Mexican axolotl so that investigators can develop research models and translate biological information that is relevant to human health and disease. The Mexican axolotl is a primary vertebrate model for organ regeneration, tissue repair, and post-embryonic development.

PI_NAMEs: VOSS, STEPHEN RANDAL (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TITLE: Ambystoma Genetic Stock Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-D(50)R]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Hepatocellular carcinoma (HCC) is an increasingly prevalent clinical problem and the second most common cause of cancer-related death. To address the magnitude of this problem, it is critically important to identify those at high risk for HCC and institute effective surveillance strategies for early diagnosis. In this competing renewal, we will build on and extend our prospective cohort of patients with cirrhosis to develop and validate blood-based and imaging-based modalities for risk stratification and early detection of HCC.

PI_NAMEs: BERETTA, LAURA  (contact);FUENTES, DAVID ;KOAY, EUGENE J

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Address;Algorithms;Artificial Intelligence;Biological Markers;biomarker panel;biomarker performance;Blood;Blood specimen;Cancer Etiology;Cessation of life;Cirrhosis;Classification;Clinic;Clinical;clinical application;clinical material;cohort;Collection;Complement;cost;curative treatments;Data;Detection;Development;Diagnosis;Diagnostic;Disease;Early Diagnosis;Enrollment;exosome;follow-up;Funding;Goals;Grant;high risk;Image;imaging biomarker;improved;Label;Lesion;Liver;Liver Cirrhosis;liver imaging;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant neoplasm of liver;Malignant Neoplasms;Maps;Measurement;Measures;Methods;Modality;Modeling;Noise;novel;novel marker;Pathologic;Patient imaging;patient population;patient stratification;Patients;Pattern;Performance;Plasma;pre-clinical;premalignant;Primary carcinoma of the liver cells;Process;prospective;Prospective cohort;Proteins;quantitative imaging;radiomics;Risk;Risk Assessment;Risk Factors;risk prediction;risk stratification;Scanning;Sensitivity and Specificity;serial imaging;Signal Transduction;Statistical Models;surveillance strategy;technology development;Testing;tool;tumor;ultrasound;United States;X-Ray Computed Tomography;α-Fetoproteins

PROJECT_TITLE: Early Detection of Hepatocellular Carcinoma


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Mental Health;Neurosciences

PI_NAMEs: BEADLE, JANELLE  (contact)

PROJECT_TERMS: Address;Adult;Affect;Age;age acceleration;age related;age related changes;age related decline;Age Years;Aging;aging process;aging related disease;Alzheimer's Disease;Area;autism spectrum disorder;base;Behavior;Behavioral;Biological;biological age;Biological Aging;Brain;brain circuitry;brain health;Brain region;Chronology;Clinical;Cognition;Cognitive;cognitive function;cognitive neuroscience;Compassion;Custom;Dementia;Development;disorder risk;DNA Methylation;Emotional;Emotions;Empathy;Executive Dysfunction;executive function;Exhibits;experience;Feeling;Frontotemporal Dementia;Functional Magnetic Resonance Imaging;Health;human old age (65+);Impaired cognition;Individual;Insula of Reil;Intervention;Knowledge;Life;life span;Link;Loneliness;Longevity;Maps;Measures;Mediating;Memory;Mental Depression;Mental Health;mental state;Methods;middle age;Molecular;mortality;Nervous System Disorder;neural;neural circuit;neural correlate;neuroimaging;Neurologic;Neuropsychology;older adult;Participant;Pathologic;patient population;Phenotype;Physiological;Population;Prefrontal Cortex;preservation;psychologic;Public Health;Quality of life;quantification of aging;Reporting;Research;Research Project Grants;Rest;Risk;Sampling;satisfaction;Schizophrenia;Severities;stressor;Testing;therapy design;therapy development;Thinking;Traumatic Brain Injury;United States

PROJECT_TITLE: The Impact of Aging on the Neural and Behavioral Bases of Empathy


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pain Research;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Improving psychosocial health for patients with chronic hip pain has a strong potential to increase engagement in physical activity and thereby reduce pain and improve physical function and well-being. The proposed Helping Improve PSychosocial Health (HIPS) mind-body intervention delivered by physical therapists through a hybrid in-person-telephone modality may be an effective and scalable solution to improve physical activity in rural populations through psychologically informed rehabilitation. Consistent with NCCIH priorities, this project may promote a paradigm shift by providing an effective treatment care model through psychologically informed rehabilitation to promote whole joint health and patient well-being for the millions of patients with chronic hip pain.

PI_NAMEs: JOCHIMSEN, KATE  (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: academic standard;acceptability and feasibility;Accounting;Adherence;Adoption;Adult;Affect;Benchmarking;Biomechanics;career development;Caring;Chronic;chronic musculoskeletal pain;chronic pain;Clinic;Clinical;Clinical Management;clinical practice;Clinical Trials;Complement;Data Collection;Development;disability;Disease;Economically Deprived Population;Education;effective therapy;Eligibility Determination;Enrollment;Feasibility Studies;feasibility testing;First Generation College Students;Fright;Functional disorder;Funding;Future;geographic barrier;Goals;Health;Hip Pain;Hip region structure;Hybrids;improved;Individual;Injury;Internet;Intervention;intervention delivery;Interview;Joints;Kentucky;Learning Skill;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;middle age;Mind-Body Intervention;mind/body;mindfulness;Mindfulness Training;Modality;Modeling;multimodality;National Center for Complementary and Integrative Health;novel;Operative Surgical Procedures;Orthopedics;Outcome;Pain;pain catastrophizing;pain reduction;Pathology;Patient Care;Patient Participation;Patients;Persistent pain;Personal Satisfaction;Persons;Physical activity;Physical Function;Physical Rehabilitation;physical therapist;Physical therapy;Positioning Attribute;preference;Procedures;Provider;psychologic;psychosocial;Psychosocial Factor;randomized, clinical trials;Randomized, Controlled Trials;Recovery;recruit;Rehabilitation therapy;Research;Research Design;Research Methodology;Research Personnel;Risk;Rural;Rural Population;satisfaction;Scientist;screening;sedentary;sedentary activity;Self Efficacy;Site;skills;socioeconomic disadvantage;Symptoms;Telephone;therapy development;Time;Training;Treatment outcome;Trust;United States National Institutes of Health;Universities;West Virginia;Wisconsin

PROJECT_TITLE: Development and feasibility of a mind-body intervention to improve physical activity for patients with chronic hip pain


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Mental Health;Neurosciences

PI_NAMEs: DA SILVA AUGUSTO, LEONARDO  (contact)

PROJECT_TERMS: acute infection;Affect;Aging;amino acid metabolism;Amino Acid Metabolism Pathway;Amino Acids;Arginine;Basic Amino Acid Transport Systems;Behavior;Behavioral;Brain;Cells;Cellular Metabolic Process;Cerebral cortex;Chronic;chronic infection;cognitive change;cognitive neuroscience;Cyst;Cytosol;Data;Development;Disease;Environment;flu;Frustration;Genes;Heart;HIV/AIDS;Immune response;Immune system;Individual;Infection;inhibitor;insight;Knock-out;Lesion;Life;Lysosomes;Measures;Mediating;Mental disorders;Metabolic;Mus;Nerve Degeneration;Nervous System Disorder;Neurocognitive Deficit;neuroinflammation;Neurologic;novel therapeutics;Nutrient;obligate intracellular parasite;Parasites;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Positioning Attribute;Publishing;Role;Stains;Supplementation;Symptoms;Techniques;Testing;Thick;Tissues;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;transcriptomic profiling

PROJECT_TITLE: The role of host amino acid metabolism in behavioral changes during latent toxoplasmosis


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative  It is now abundantly clear that mutations in many of the key proteins involved in human recombinational DNA repair result in chromosomal instability which, in turn, translates into a predisposition for cancers. The results from these studies will provide unique molecular insights into the macromolecular assemblies that are crucial for genetic stability and tumour suppression. Understanding the function of these proteins, and the failings of proteins defective in this process is consequently of importance to human health.

PI_NAMEs: KOWALCZYKOWSKI, STEPHEN CHARLES (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Affect;BARD1 gene;Biochemical;BRCA1 gene;BRCA2 gene;cancer predisposition;Chromosomal Instability;Complex;Defect;DNA;DNA Repair;Enzymes;Event;Excision;Exodeoxyribonuclease I;Genetic;Genome Stability;Health;helicase;homologous recombination;Human;Individual;insight;Knowledge;macromolecular assembly;Malignant Neoplasms;Methods;Molecular;molecular imaging;mutant;Mutation;novel;novel therapeutic intervention;PALB2 gene;paralogous gene;Pathologic;Pathway interactions;Predisposition;Process;protein function;Proteins;RAD51C gene;Rationalization;reconstitution;Resected;Role;single molecule;Single-Stranded DNA;Technology;Translating;Tumor Suppression;Tumor Suppressor Proteins;Visualization;XRCC2 gene;XRCC3 gene

PROJECT_TITLE: Functions of BRCA1 and RAD51 Paralogs in Genome Stability and Tumor Suppression via Homologous Recombination


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Mental Health;Neurosciences

PROJECT_TERMS: Aging;animal imaging;Animal Model;Behavior;Behavior assessment;Behavioral Research;Cognition Disorders;cognitive neuroscience;cognitive testing;Communities;Data Set;Development;Equipment;experimental study;Funding;image translation;imaging facilities;imaging modality;imaging study;improved;in vivo imaging;Individual;Infrastructure;innovation;instrumentation;Interdisciplinary Study;Magnetic Resonance Imaging;Mentors;Methodology;Modality;Multimodal Imaging;multiphoton microscopy;neural;Neurocognitive;neurocognitive disorder;Neurodegenerative Disorders;Neurodevelopmental Disorder;Optics;Positron-Emission Tomography;pre-clinical;preclinical imaging;Research;Resources;Rodent;Structure;Study models;translational model

PROJECT_TITLE: Translational Imaging and Behavioral Assessment (TIBA) Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Mental Health;Neurodegenerative;Neurosciences;Sleep Research

PI_NAMEs: ZHONG, PENG  (contact)

PROJECT_TERMS: Ablation;Address;Affect;Age Months;age related;age related changes;Aging;Alzheimer's Disease;Alzheimer's disease patient;Animal Behavior;Area;Behavior assessment;Behavioral;Brain;Calcium;Caregivers;cell type;cerebral atrophy;Cerebrospinal Fluid;Characteristics;Clinical;Cognitive;Cognitive deficits;cognitive development;cognitive enhancement;cognitive function;cognitive neuroscience;cognitive performance;Core Facility;Data;Defect;Development;Dreams;Electroencephalography;Exhibits;Funding;Generations;Genetic;genetic approach;Hippocampus;Human;Hypothalamic structure;Image;Impaired cognition;improved;improvement on sleep;in vivo;in vivo calcium imaging;Lateral;Learning;Maintenance;MAPT gene;Mediating;Medical center;melanin-concentrating hormone;Membrane;Memory;Memory impairment;Mission;Monitor;morris water maze;mouse model;Mouse Strains;Mus;Mutation;Nebraska;Neurofibrillary Tangles;neuromechanism;neuron loss;Neurons;neuropathology;non rapid eye movement;novel therapeutic intervention;patch clamp;Pathology;Patients;Pattern;Phase;Play;preference;protein expression;Publishing;rapid eye movement;Regulation;REM Sleep;Research;Role;Severities;Sleep;sleep abnormalities;Sleep Architecture;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep pattern;sleep quality;sleep regulation;Sleep Wake Cycle;Slice;spatial memory;tau Proteins;Tauopathies;Testing;Therapeutic Intervention;United States National Institutes of Health;Universities

PROJECT_TITLE: Hypothalamic Sleep-Wake Neuron Defects in Alzheimer’s disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative Changes in attention and goal-directed cognition are likely contributors to age-related memory decline and serve as an impediment to daily living. In cognitively `healthy' older adults, preclinical Alzheimer's disease (AD) pathology may nonetheless disrupt attention and goal coding, with deleterious consequences for memory. Using innovative technologies from neuroscience and psychological science, together with biomarkers for AD- related pathology, the proposed research will increase understanding of (a) how moment-to-moment and individual differences in attention and goal coding affect learning and remembering in young and older adults, and (b) how these differences relate to memory decline in aging with and without AD pathology, which holds promise for revealing novel neurocognitive biomarkers for AD risk.

PI_NAMEs: WAGNER, ANTHONY D (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Accounting;Address;Adopted;Affect;Age;age difference;age related;age related changes;Aging;Alzheimer disease detection;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Arousal;Attention;Behavioral;Behavioral Assay;Behavioral Sciences;Biological Assay;Biological Markers;Categories;Code;Cognition;Cognitive;cognitive neuroscience;Color;Data;Diameter;Disease;distraction;Episodic memory;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Goals;Grain;healthy aging;Hippocampus;indexing;Individual;Individual Differences;innovation;innovative technologies;Learning;Link;Location;locus ceruleus structure;Magnetic Resonance Imaging;Measures;medial temporal lobe;Mediating;Memory;memory encoding;Memory impairment;Memory Loss;memory recognition;memory retrieval;Molecular;multimodality;Multivariate Analysis;neural;neural network;Neurocognitive;Neurosciences;novel;novel marker;older adult;pathological aging;Pathology;Pattern;Performance;Positron-Emission Tomography;pre-clinical;Probability;Process;psychologic;Public Health;Pupil;Research;Resolution;Retrieval;Science;Short-Term Memory;Site;Sorting;Source;Specific qualifier value;Stimulus;Structure;theories;tool;young adult;β-amyloid burden

PROJECT_TITLE: Effects of attention and goal-state lapses on memory in healthy and pathological aging

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Our goal is to understand the genetic and molecular basis of selfish chromosomes and speciation in animals, including humans. We are using a multidisciplinary approach and developing new techniques to identify genes and molecular pathways that evolve rapidly between species and cause defects in hybrids. Our studies will provide a unique perspective to fundamental cellular processes that are important in cancer biology and birth defects in humans.

PI_NAMEs: PHADNIS, NITIN  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Animals;arms race;autosome;base editing;Behavior;Biological;Cancer Biology;Candidate Disease Gene;causal variant;Cell Physiology;Cells;Chromosome inversion;Chromosome Mapping;Chromosomes;comparative;Complement;Complex;Congenital Abnormality;CRISPR/Cas technology;Defect;Drosophila genus;Elements;Engineering;Enhancers;Evolution;Frequencies;gene discovery;Genes;Genetic;genetic approach;genetic architecture;Genetic Recombination;Genome;Genome engineering;Genomics;Germ Cells;Goals;Human;Hybrids;in silico;insight;interdisciplinary approach;Laws;Length;Link;Maps;Meiosis;Methods;Molecular;Mutagenesis;Mutagens;Pathway interactions;Recombinants;segregation;segregation distortion;Selfish Genes;sex;Sex Behavior;Sex Chromosomes;Sex Ratio;Shapes;Sister;Site;Sorting;System;Techniques;Technology;Testing;theories;Time;tool;Variant;Work

PROJECT_TITLE: The mechanisms of segregation distortion in Drosophila

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]