ORG_CITY: ITHACA

ORG_DEPT: CHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: The proposed research is relevant to public health by generating fundamental knowledge of bacterial extracellular electron transfer that underlines these bacteria's ability in detoxifying heavy metals and toxic organics. This knowledge can help improve bioremediation and wastewater treatment technologies toward removing health threats to surrounding communities. Thus, the proposed research is relevant to the part of NIGMS's mission that pertains to laying the foundation for disease prevention.

PI_NAMEs: CHEN, PENG  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Agriculture;Bacteria;Biochemical;Biological;Biological Assay;Bioremediations;cell envelope;Cells;cellular imaging;Chromium;Communities;Cytochromes;disorder prevention;Drug Metabolic Detoxication;electron donor;Electron Transport;Electrons;Engineering;Ensure;Environment;extracellular;Fluorescence Microscopy;Foundations;Friends;genetic manipulation;Goals;Gram-Negative Bacteria;ground water;Health;Heavy Metals;Human;Human Activities;imaging approach;improved;Industrialization;innovation;insight;interest;Knowledge;knowledge base;Measurement;Mediating;Membrane;Metabolism;Metals;Microbe;Microscopy;Mission;Molecular;National Institute of General Medical Sciences;novel;Organism;Outcome;Oxidants;Oxidation-Reduction;Oxygen;Pathway interactions;Pattern;periplasm;Personal Satisfaction;pollutant;Pollution;Population;Process;Proteins;Public Health;Reaction;Research;Respiration;Shewanella;single molecule;Site;Spatial Distribution;spatiotemporal;Technology;Testing;Time;Uranium;Work

PROJECT_TITLE: Mechanism of extracellular electron transfer in Gram-negative bacteria

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: TR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AMHERST

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: The University at Buffalo Clinical and Translational Science Institute (CTSI) is the coordinating center of the Buffalo Translational Consortium, which includes the region's premier research, educational and clinical institutions with influential community partners. The vision of the CTSI is to perform innovative clinical and translational research to reduce health disparities and improve the health of our community and the nation. We engage our community as research partners to create a shared environment to bring discoveries in the laboratory, clinic and community to benefit individual and public health.

PI_NAMEs: MURPHY, TIMOTHY F (contact)

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TERMS: Acceleration;Achievement;Address;Adopted;African American population;biomedical informatics;Center for Translational Science Activities;Cities;Clinic;Clinical;clinical center;clinical data repository;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engagement;Community Health;community partners;community partnership;County;Coupled;Cultural Backgrounds;Data;data integration;data sharing;Diverse Workforce;Education;education research;Environment;experience;Fostering;Foundations;Funding;Future;Genetic;Goals;Growth;Health;health disparity;Health Personnel;Health Professional;Health Sciences;Healthcare;Healthcare Systems;Heart;Image;image translation;Imaging technology;improved;Individual;Influentials;Informatics;informatics tool;innovation;Institution;interoperability;Knowledge;Laboratories;Learning;Life Expectancy;life span;Medical;Medical center;Medical Research;medical schools;Methods;multidisciplinary;multiple data sources;Natural Language Processing;New York;novel;novel strategies;Outcomes Research;Participant;Pediatric Hospitals;Persons;Phenotype;Population;Poverty;Process;Program Development;Prospective Studies;Public Health;Public Health Informatics;Recording of previous events;recruit;Recruitment Activity;Reduce health disparities;Refugees;Research;Research Institute;Research Personnel;Resources;response;Schools;Science;Sensitivity and Specificity;sharing platform;Site;skills;social health determinants;Special Population;Speed;Strategic Planning;structured data;System;Testing;tool;Training;translational impact;translational pipeline;Translational Research;translational scientist;Translations;Underrepresented Minority;Universities;unstructured data;Vision;Work;Workforce Development

PROJECT_TITLE: University of Buffalo Clinical and Translational Science Institute


NIH_SPENDING_CATS: Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The Institute of Translational Health Sciences (ITHS) seeks to improve the quality and efficiency of clinical and translational research across Washington, Wyoming, Alaska, Montana, and Idaho and beyond. The Institute will achieve this goal through education and training, team building, community engagement, continuous process improvement, and advanced informatics.

PI_NAMEs: AMORY, JOHN K. (contact)

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Alaska;Benchmarking;Big Data;Career Choice;Career Mobility;Child;Clinic;Clinical;Clinical and Translational Science Awards;Clinical Data;Clinical Research;Clinical Sciences;clinical training;Clinical Trials;cohort;Collaborations;collaboratory;Communities;community academic partnership;community engagement;Community Health;Competence;data exploration;Data Science;data sharing;Disparity;diversity and equity;doctoral student;early-career faculty;Education;Educational Curriculum;Electronic Health Record;Ensure;Environment;Equity;evidence based guidelines;Faculty;Fostering;Fred Hutchinson Cancer Research Center;Funding;Future;Goals;Growth;Guidelines;Health;health training;Healthcare;Idaho;improved;Individual;Informatics;informatics tool;Infrastructure;innovation;Institution;Investments;Laboratories;Leadership;Learning;life span;Location;Machine Learning;Methods;Minority Groups;Montana;novel;outreach;Pathway interactions;Patients;Performance;Persons;Phase;Policies;pre-doctoral;Predictive Analytics;Process;process improvement;professional students;programs;Publications;Relationship-Building;remote technology;Research;Research Personnel;Research Project Grants;research to practice;Resources;Rewards;Role;Rural Community;Rural Health;Rural Population;Science;Services;skills;Special Population;success;System;Testing;Time;TNFSF15 gene;tool;Training;Training and Education;translational health science;Translational Research;translational scientist;Universities;Vision;Washington;Workforce Development;Wyoming


ADMINISTERING_IC: MH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Disorders causing cognitive impairments have devastating effects on our daily lives, including severe problems in forming new and retrieving exiting memories. Multiple distinct learning systems store our different kinds of memories, like skills or directions, but remarkably, these systems are not independent and can interact in both beneficial and disruptive ways. Our research aims to use such learning interactions as an opportunity to understand the cognitive processes that coordinate the different learning systems and to thereby reveal how cognitive impairments can broadly disrupt learning and memory even without affecting the learning system themselves.

PI_NAMEs: WOLFF, STEFFEN  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Acute;Affect;Animals;Area;arm;Automobile Driving;Back;Behavioral;Behavioral Paradigm;Brain;Cognitive;cognitive control;cognitive process;common rule;Corpus striatum structure;Custom;density;Dependence;Development;Diagnostic Procedure;diagnostic tool;Disease;Electrophysiology (science);Event;experience;experimental study;Face;Genetic;genetic manipulation;Grain;Grant;high dimensionality;Hippocampus;Impaired cognition;Impairment;Implant;improved;in vivo;Individual;Infrastructure;Infusion Pumps;insight;kinematics;Learning;Learning Skill;Life;Lifting;Machine Learning;Mediating;member;Memory;Mental disorders;Motion;motor skill learning;Motor Skills;Movement;Nature;neural;Neurodegenerative Disorders;neuronal circuitry;Neurons;novel diagnostics;optogenetics;Output;Pattern;Performance;Population;Prefrontal Cortex;prevent;Process;programs;Radial;Rattus;Research;Resources;Role;skills;Stereotyping;Stream;Structure;System;Techniques;Testing;Time;Training;Work

PROJECT_TITLE: A circuit mechanism for the interactions between distinct learning systems

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Yale Center for Clinical Investigation (YCCI) has been a leader and strong partner with other CTSA hubs in research democratization to diverse populations, enhancement of the electronic health record to promote translational science, and leveraging the broad expanse of Yale University's outstanding T1 to T4 multi-School scientific environment with the clinical strength of Yale New Haven Health System to create a learning health system that reaches into communities. YCCI will work with other CTSAs to foster the further growth of multidisciplinary team science, develop innovative collaborative precision-health based strategies for disease prevention, diagnostics, and therapeutics, and implement to obtain real-world beneficial results for the benefit of all populations in the learning health system.

PI_NAMEs: KRYSTAL, JOHN H.;SMITH, BRIAN RICHARD (contact)

PROGRAM_OFFICER_NAME: MERCHANT, CAROL

PROJECT_TERMS: Acceleration;actionable mutation;Address;Area;Beds;bioimaging;Bioinformatics;Biometry;career;career development;Catchment Area;Clinical;Clinical and Translational Science Awards;clinical care;clinical center;clinical investigation;Clinical Research;Collaborations;Communities;community based research;Connecticut;County;Data;data resource;Democracy;Diagnostic;disorder prevention;Education;Electronic Health Record;Environment;Ethics;exome sequencing;Faculty;Family;Fellowship Program;forging;Fostering;Functional disorder;Funding;Future;Generations;Genomics;Grant;Growth;Health;health care disparity;Health equity research;Health system;Healthcare;Healthcare Systems;Heart;Home;Hospitals;Image;Imprisonment;Improve Access;Industry;Informatics;informatics infrastructure;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;International;Investments;Learning;Link;member;Methodology;Mission;multidisciplinary;multiple omics;new technology;next generation;novel;Outpatients;patient population;Patients;personalized health care;personalized intervention;personalized medicine;Pilot Projects;point of care;Population;Population Heterogeneity;post-doctoral training;pre-doctoral;Precision Health;programs;Public Health;Public Health Informatics;Randomized;recruit;Reproducibility;Research;research and development;Research Infrastructure;Research Personnel;Research Support;Research Training;Resources;Rhode Island;Role;Scholars Program;Schools;Science;Scientific Advances and Accomplishments;Scientist;Shapes;Site;Special Population;Talents;Technology;Therapeutic;Training;Training Programs;translational impact;translational pipeline;Translational Research;translational scientist;Translations;United States National Institutes of Health;Universities;Visit;Wood material;Work

PROJECT_TITLE: Yale Clinical and Translational Science Award


NIH_SPENDING_CATS: Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Narrative  The roles of circular RNAs in sepsis-associated systemic inflammation, inflammatory lung responses, and end- organ damage, such as lung injury, remain largely unclear, particularly in the elderly. We will investigate whether aging regulates circRNA levels and whether aging-associated circRNA changes facilitate bacterial infection- induced inflammation and activation of macrophages.

PI_NAMEs: JIN, YANG  (contact)

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TERMS: Acute Respiratory Distress Syndrome;aged;Aging;aging mechanism;aging related;Anti-Inflammatory Agents;Bacterial Infections;bactericide;Biological Process;Bronchoalveolar Lavage Fluid;Cells;circular RNA;clinically significant;Computer Models;Data;Development;diagnostic biomarker;Disease;Elderly;extracellular vesicles;Funding;Future;Genes;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Grant;Half-Life;Host Defense;Human;In Vitro;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Intention;Lung;lung injury;Macrophage;Macrophage Activation;Mammals;Methods;MicroRNAs;Morbidity - disease rate;mortality;Mus;Natural Immunity;novel;novel diagnostics;novel therapeutics;old mice;older patient;Organ;Organ failure;organ injury;Organism;Pathogenesis;pathogenic microbe;Pathologic;Pathologic Processes;Persons;Physiological;Pneumonia;Population;Predisposition;Protocols documentation;Pseudomonas aeruginosa;Pulmonary Inflammation;Regulation;Regulator Genes;Reporting;Resistance;response;ribonuclease R;RNA;Rodent;Role;Runaway;Sepsis;Specificity;Structure;System;systemic inflammatory response;Testing;Therapeutic;therapeutic biomarker;Tissues;United States National Institutes of Health;Work;Writing;young adult

PROJECT_TITLE: Novel Targets in aging-associated sepsis and organ failure

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE – OVERALL The UK CTSA program hub is uniquely positioned in the National CTSA Consortium to foster novel technologies, team science, clinical trial start-up and cutting-edge translational research across the lifespan. Our UK CTSA hub has a significant presence on the national stage, and our focus on the Central Appalachian community, a rural region with many of the highest priorities (i.e., cardiovascular, neuroscience, cancer, obesity/diabetes) of health disparities in the nation and an epicenter for the opioid and substance abuse epidemic, distinguishes our mission and activities. The programs in this proposal will ultimately elevate the health and quality of life for people of this region and provide a national model for rural, underserved populations. Project Narrative Page 277

PI_NAMEs: KERN, PHILIP A (contact)

PROGRAM_OFFICER_NAME: DOYLE, JAMIE MIHOKO

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Agriculture;Appalachian Region;Award;Cardiovascular system;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Research;clinical research site;Clinical Sciences;Clinical Trials;Collaborations;collaborative environment;college;Communities;community engagement;community research;Complement;Computer software;COVID-19 pandemic;Dedications;Development;Diabetes Mellitus;Discipline;Distress;diversity and inclusion;Economics;Engineering;Environment;Epidemic;Fostering;Funding;Future;Generations;Grant;Growth;Health;health disparity;health equity;health inequalities;Health Sciences;Health Status;Healthcare;Home;improved;innovation;Institution;Integrated Health Care Systems;inter-institutional;Intervention;Investments;Kentucky;Lead;life span;Malignant Neoplasms;Medical;Medical center;Mission;Modeling;National Center for Advancing Translational Sciences;Neurosciences;new technology;Obesity;opioid abuse;Participant;patient engagement;Patients;Persons;Phase;Policies;Population;Positioning Attribute;programs;Quality of life;recruit;Reporting;Research;Resources;response;Rural;rural area;Rural Community;Rural Health;Science;Sports;Substance abuse problem;Substance Use Disorder;Translational Research;Translations;Underserved Population;United States;Universities;West Virginia;Work

PROJECT_TITLE: Kentucky Center for Clinical and Translational Science


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The UCSD Clinical and Translational Research Institute (CTRI) will continue to support and transform clinical research by providing guidance and support from initial planning of research through data analysis and dissemination. It will provide an educational pipeline to train the next generation of clinical and translational scientists and involve the community in setting the direction and priorities of the organization. The CTRI will foster development of novel technologies that facilitate clinical research and support investigators by providing the services needed to conduct clinical research and improve health. Page 127 Project Narrative

PI_NAMEs: FIRESTEIN, GARY S (contact);HOGARTH, MICHAEL ;SMITH, DAVID MITCHELL

PROGRAM_OFFICER_NAME: ATIENZA, AUDIE A

PROJECT_TERMS: Abbreviations;Acceleration;Applied Research;biobank;Bioinformatics;biomedical informatics;Biomedical Research;California;career development;Certification;Clinic;Clinical;Clinical Data;clinical data warehouse;clinical infrastructure;clinical investigation;Clinical Research;clinical trial readiness;Clinical Trials;cloud based;Collaborations;Communication;Communities;community clinic;community empowerment;community engagement;community involvement;Community Physician;Computational Biology;Creativeness;Data;Data Analyses;data dissemination;data visualization;Decision Making;Development;Devices;Discipline;Diverse Workforce;drug discovery;Ecosystem;Education;Electronic Health Record;Engineering;Fostering;Friends;Future;Goals;Grant;Health;Health protection;Health Sciences;Healthcare;Heterogeneity;Hispanic Populations;Hospitals;Human;Immunogenomics;Immunology;improved;Informatics;informatics infrastructure;informatics tool;Information Systems;Infrastructure;innovation;Institution;Institutional Review Boards;Interdisciplinary Study;Investigation;Life Cycle Stages;life span;Link;Medical;Medical center;medical schools;Medicine;Mentors;Methamphetamine;Methods;mobile application;mobile computing;Monitoring Clinical Trials;multidisciplinary;National Center for Advancing Translational Sciences;Native Americans;Neighborhood Health Center;new technology;next generation;novel;online course;outreach;Patients;Pediatric Hospitals;Peer Review;Pharmaceutical Preparations;Pharmacy facility;Phase;Process;process improvement;programs;Public Health;Public Health Schools;quality assurance;recruit;Registries;Research;Research Ethics;Research Institute;Research Methodology;Research Personnel;Research Support;Resources;Sampling;School Nursing;Schools;Science;science teacher;Scientist;Secure;Services;social media;software systems;Special Population;support tools;Testing;Training;Training and Education;Training Programs;Translating;Translational Research;translational scientist;Underrepresented Minority;underserved community;Universities;user-friendly;virtual;virtual reality game;Visualization software;Vulnerable Populations;Workforce Development;Writing

PROJECT_TITLE: UC San Diego Clinical and Translational Research Institute


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: SAN ANTONIO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Senescent cells are typically harmful in many tissues due to their secretion of inflammatory factors in the local microenvironment, however, the specific impact of senescent neurons on brain aging and dementia remains unknown. This study utilizes laboratory experiments to generate multi-omic datasets from the human brain and employs customized deep learning techniques for analyzing spatial omics data. The aim is to identify the precise effects of senescent neurons on their microenvironments and use mouse models to evaluate potential molecular regulators and treatments that could alleviate these detrimental effects.

PI_NAMEs: ORR, MIRANDA ETHEL;ZARE, HABIL  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Address;Affect;Age;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;Area;Autopsy;Brain;brain cell;brain tissue;Candidate Disease Gene;candidate identification;CD95 Antigens;Cell Aging;Cell Nucleus;Cell secretion;cell type;Cells;Characteristics;Chronic;Cyclin-Dependent Kinase Inhibitor;cytokine;Data;Data Set;deep learning;deep learning model;Dementia;design;Development;digital;Disease Progression;effective therapy;Evaluation;experimental study;Genes;Human;Immunomodulators;in silico;In Vitro;in vivo;Induction of Apoptosis;Inflammation;Inflammatory;interest;Knowledge;laboratory experiment;Light;Link;Machine Learning;Mission;Modeling;Molecular;molecular imaging;molecular marker;mouse model;Multiomic Data;nano-string;Nerve Degeneration;neural;Neurofibrillary Tangles;neuron loss;Neurons;novel;novel marker;Outcome Study;overexpression;Pathogenesis;Pathogenicity;Pathologic;pathological aging;Pathology;Pathway interactions;Phase;postmitotic;protein profiling;Proteins;proteogenomics;Resolution;Role;Sampling;Seminal;senescence;senescent cell;senolytics;tau Proteins;Techniques;Technology;Testing;Therapeutic;Tissues;TNFRSF6 gene;Training;Transcript;transcriptome;Transgenic Mice;translational approach;United States National Institutes of Health;Work

PROJECT_TITLE: The pathogenic effects of senescent cells on their microenvironments and their role in human brain aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-2 (M2)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Immunotherapy;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: DERMATOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Oral mucosal immune-related adverse events secondary to anti-PD-1 can cause serious morbidity and pain; here, we seek to understand the pathogenesis of these oral mucosal adverse events. Here we propose an innovative plan incorporating interrogation of human specimens, generation and analysis of novel mouse models, and validation using patient-derived organoid cultures. This work is highly relevant to cancer patients' oral health given the increasing use of immune stimulating systemic agents and the significant morbidity of these oral mucosal side effects.

PI_NAMEs: KULKARNI, RAJAN P. (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: 3-Dimensional;Adrenal Cortex Hormones;Adverse event;Air;anti-PD-1;anti-PD-1/PD-L1;anti-PD1 therapy;Atopic Dermatitis;Autoimmune;Bioinformatics;Biological Models;Biopsy;Bullous Pemphigoid;Cancer Patient;cancer therapy;CD4 Positive T Lymphocytes;cell type;Cells;Clinical;Clinical Management;Clinical Trials;clinically relevant;Colitis;Complex;Cutaneous;cytokine;Data;Data Set;Development;dimensional analysis;Endocrine System Diseases;Equilibrium;Evidence based treatment;Exhibits;experience;Future;Gene Expression Profile;Generations;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;high dimensionality;Human;human tissue;IL17 gene;Immune;immune checkpoint blockade;immune modulating agents;immune-related adverse events;Immunologic Stimulation;immunological diversity;Immunology;immunomodulatory therapies;Immunotherapy;improved;In Vitro;Inbred NOD Mice;Incidence;Inflammation;Inflammatory;Informatics;innovation;insight;Interleukin-6;Interruption;Investigation;Knowledge;Lichenoid Eruptions;Liquid substance;Malignant Neoplasms;Methods;Modeling;Molecular Profiling;Morbidity - disease rate;mouse model;Mucositis;Mucous Membrane;novel;Operative Surgical Procedures;Oral;Oral cavity;Oral health;Oral mucous membrane structure;Organoids;Outcome;Pain;Pathogenesis;Pathologic;Pathology;Patients;Pattern;personalized approach;pharmacologic;Phenotype;predictive marker;prevent;Prevention strategy;programmed cell death protein 1;prospective;Psoriasis;Publishing;Quality of life;Regulatory T-Lymphocyte;Reporting;Sampling;Secondary to;Sialadenitis;side effect;single-cell RNA sequencing;Specimen;Stomatitis;success;T-Lymphocyte;Testing;Therapeutic;Thyroiditis;Tissues;TNF gene;Toxic effect;treatment optimization;Treatment Protocols;treatment strategy;tumor;Ulcer;Validation;Work

PROJECT_TITLE: Identifying and modulating pathologic T cells that govern oral mucosal immune related adverse events from immune checkpoint blockade

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Fungi are a vast and biologically diverse group of organisms that affect all of our lives in myriad ways. Fungi are important causes of human and crop diseases, affecting literally billions of lives each year. Most of these devastating effects occur through the loss of life of infected and immunocompromised patients, as well as loss of crop yield throughout the world. Additionally, fungi are also important scientific models to better understand basic physiology of more complex organisms, such as humans. In this program, we are training the next generation of scientists to explore fungi in many areas of biological investigation, both as infectious agents as well as model systems to understand genetic disorders and evolution and plant-fungal symbiotic interactions.

PI_NAMEs: ALSPAUGH, ANDREW ;HEITMAN, JOSEPH  (contact);MAGWENE, PAUL MITAARI

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Institution;Molecular;Pathogenesis;The science of Mycology;Training Programs

PROJECT_TITLE: Tri-Institutional Molecular Mycology and Pathogenesis Training Program

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Sleep health is essential for well-being, yet significant disparities exist for young children (2-5 years old) who are racially minoritized or living in poverty. The objective of this research is to define disparities in early sleep health by examining how socio-cultural, neighborhood, and family risk factors predict conditions in children's sleeping environment and sleep health. This study will provide a critical next step in reducing disparities in early childhood sleep health and its downstream effects.

PI_NAMEs: BATES, RANDI  (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: 5 year old;Absenteeism at work;Academy;Accounting;actigraphy;Adult;Affect;Age Months;alertness;American;Area;Behavior;Biological Markers;Biology;Birth;Black race;Child;Childhood;Cohort Studies;Collaborations;critical period;design;Development;developmental psychology;Diagnosis;Dimensions;Disadvantaged;Discipline;Discipline of Nursing;Disparity;disparity reduction;Distal;early childhood;Ecological momentary assessment;Ecology;Education;Emergency Situation;Environment;Equation;Evidence based treatment;experience;Family;Funding;gene environment interaction;Geographic Information Systems;Geographic Locations;Goals;Health;health disparity;health inequalities;Health Policy;help-seeking behavior;Hour;Housing;housing instability;Income;Individual;Inequity;infancy;innovation;Intervention;Investigation;Justice;kindergarten;Learning;Link;Longitudinal Studies;Low income;Measures;media use;Mediation;Mediator;Mental Health;Methodology;Midwestern United States;Modeling;Names;National Heart, Lung, and Blood Institute;neighborhood disadvantage;Neighborhoods;Outcome;Parents;Patient Self-Report;Pediatrics;Personal Satisfaction;Physiological;poor sleep;population health;Poverty;Predictive Factor;prevent;Prevention;Primary Care;prospective;Race;racial diversity;racial minority;racism;recruit;remediation;Research;Research Personnel;Resources;Risk Factors;satisfaction;Schools;Science;Sleep;Sleep Deprivation;sleep health;social culture;Social Environment;social health determinants;Sociology;statistics;Strategic Planning;Stress;System;Testing;Time;Toddler;United States National Institutes of Health;Walking

PROJECT_TITLE: Defining Relationships of Early Mediators and Moderators of Sleep (DREAMS)

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative Traumatic brain injury (TBI) across the lifespan has been shown to progress towards Alzheimer’s disease (AD) and related dementias (ADRD); however, what is missing is a well characterized TBI rodent model that recapitulates ADRD features (cognitive decline, atrophy, inflammation, amyloid-β, etc.). This project will utilize a rodent closed head injury model to assess age of injury and AD risk alleles across the lifespan using clinically relevant outcome measures to deeply characterize how TBI leads to ADRD symptomology.

PI_NAMEs: OBENAUS, ANDRE  (contact);TERRITO, PAUL RICHARD

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: 3-Dimensional;abeta accumulation;abeta deposition;Acceleration;Address;Adolescent;Age;age related;aged;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Animal Model;Animals;apolipoprotein E-4;Atrophic;behavioral outcome;Biological Factors;Biological Markers;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;Brain;Brain Injuries;cerebral atrophy;Chronic;Clinical;clinical translation;clinically relevant;Closed head injuries;Cognitive;cognitive testing;Communities;Data;data modeling;Development;Diffusion;Disease;Disease Progression;Dissociation;Early Diagnosis;Ensure;Evolution;Exhibits;Exposure to;Face;Functional disorder;Funding;Genetic;genetic risk factor;Genotype;Histopathology;Human;human data;Image;Impaired cognition;Individual;Inflammation;Injury;innovation;Knowledge;Life;life span;Liquid substance;Magnetic Resonance Imaging;Maps;Measures;Metabolic;Modality;Modeling;Monitor;mouse model;multimodal data;multimodality;Mus;Nerve Degeneration;neuroimaging;neuroinflammation;neuron loss;neuropathology;Outcome;Outcome Measure;Pathologic;performance site;Phenotype;Positron-Emission Tomography;Pre-Clinical Model;Predisposition;Procedures;protein biomarkers;Protocols documentation;Reproducibility;Research;Resources;Risk Factors;risk variant;Rodent;Rodent Model;Role;role model;sex;Site;Structure;Symptoms;TBI Patients;Testing;Therapeutic;tool;Traumatic Brain Injury;Traumatic brain injury related dementia;Validation;vascular abnormality;Visual

PROJECT_TITLE: Modeling the role of age at traumatic brain injury in the development of Alzheimer's Disease and related dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-B (55)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SALSBURY COVE

ORG_NAME: MOUNT DESERT ISLAND BIOLOGICAL LAB

ORG_STATE: ME

PHR: OVERALL PROJECT NARRATIVE Research in the Davis Center is uniquely focused on using diverse animal models to define the cellular and molecular mechanisms of tissue regeneration and aging, and on translating that information into new regenerative medicine therapies and improvements to healthspan. This Phase III COBRE proposal will transition state of the art core facilities at MDIBL in comparative animal models, bioinformatics and data science, and light microscopy to self-sustainability and support a pilot project program in aging and regenerative biology which will enable MDIBL investigators, visiting scientists, pilot project awardees, and MDIBL course participants to build highly competitive research programs. Core support will consolidate the progress made after hiring, promoting, and retaining successful COBRE investigators in the MDIBL Davis Center and building this Center into a leading research institute in Comparative Biology.

PI_NAMEs: DRUMMOND, IAIN A. (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Address;Aging;aging mechanism;aging reversal;animal data;Animal Model;Area;Bioinformatics;Biological;Biomedical Research;career;cell regeneration;Centers of Research Excellence;Chronic Disease;Collaborations;comparative;Comparative Biology;comparative genomics;Comparative Study;Core Facility;Data;Data Science;Development;disease model;drug candidate;Educational workshop;Elements;Ensure;Environment;Fees;Foundations;functional improvement;fundamental research;Funding;Funding Opportunities;Goals;Grant;healthspan;Human;human tissue;Imaging technology;improved;innovation;Institution;Intervention;Invertebrates;Investments;Laboratories;laboratory curriculum;Laboratory Research;Learning;Legal patent;life span;Light;light microscopy;Link;Maine;Metabolic Pathway;Microscopy;model organism;Molecular;Natural regeneration;New England;Organ;organ regeneration;Organism;Participant;Pathway interactions;Patients;Phase;Pilot Projects;Play;Program Research Project Grants;programs;Publications;recruit;regenerative biology;Regenerative Medicine;Regenerative research;repaired;Research;Research Activity;Research Infrastructure;Research Institute;Research Personnel;Role;Scientist;screening;Services;small molecule;State Government;success;superresolution microscopy;Technology;technology development;Tissue Preservation;tissue regeneration;tissue repair;Tissues;tool;Translating;Travel;Vertebrates;Visit

PROJECT_TITLE: The MDIBL Center for Comparative Biology of Tissue Repair, Regeneration and Aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-4 (C3)]


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Regenerative Medicine

PROJECT_TERMS: Advisory Committees;Aging;base;Biological;Biological Sciences;Biology of Aging;Biomedical Research;Budgets;Businesses;career;Centers of Research Excellence;Client;Communication;Comparative Biology;Core Facility;Development;Development Plans;disease model;Ensure;Environment;Evaluation;Faculty;Fee-for-Service Plans;Funding;Funding Opportunities;Future;Goals;Grant;Growth and Development function;Guidelines;Individual;Information Dissemination;innovation;Laboratories;Leadership;Legal patent;Logistics;Maine;meetings;National Institute of General Medical Sciences;Natural regeneration;operation;organizational structure;Phase;Pilot Projects;Program Evaluation;programs;Progress Reports;Publications;recruit;regenerative;regenerative biology;Regenerative Medicine;Regenerative research;Reporting;Research;Research Contracts;Research Infrastructure;Research Personnel;Resources;Services;State Government;Stream;success;synergism;System;Technology;tissue repair;tool

PROJECT_TITLE: Administrative Core


PI_NAMEs: SECKELER, EDWARD  (contact)

PROJECT_TERMS: African;age related;Aging;aging mechanism;Ambystoma;Animal Experimentation;Animal Husbandry;Animal Model;animal resource;Animals;anti aging;Applications Grants;Aquaculture;Biological Sciences;Biology;Budgets;Caenorhabditis elegans;Centers of Research Excellence;Charge;Chronic;comparative;Comparative Biology;Comparative Study;Core Facility;cost;Degenerative Disorder;Drosophila genus;Educational process of instructing;Embryo;Ensure;Exhibits;experimental study;Faculty;Fee-for-Service Plans;feeding;Fees;food preparation;Funding;Gene Transfer Techniques;Genetic;Genetic Models;Goals;hallmarks of aging;Healthcare Systems;healthspan;healthy aging;Heart;Human;human tissue;Injury;innovation;Institution;interest;International;Internships;Invertebrates;Kidney;Killifishes;Laboratories;Lead;Legal patent;life span;Limb structure;Maintenance;Mammals;Metabolic Pathway;model organism;Modeling;mutant;Natural regeneration;Nematoda;Organ;organ regeneration;Paper;Participant;Pathway interactions;Phase;Pilot Projects;Positioning Attribute;Process;Productivity;programs;Protocols documentation;Publications;Quality Control;Quarantine;recruit;regeneration potential;regenerative;regenerative biology;Regenerative capacity;Regenerative Medicine;Regenerative research;Regenerative response;repaired;Research;Research Personnel;Research Project Grants;Research Support;Resources;response to injury;Schools;Scientist;Services;small molecule;Spinal Cord;stem cell biology;Structure;Students;Study models;success;summer program;System;tissue regeneration;tissue repair;Training and Education;Training Programs;Transgenic Organisms;Vertebrates;Visit;Vocation;Zebrafish

PROJECT_TITLE: Comparative Animal Models (CAM) Core


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Regenerative Medicine

PI_NAMEs: GRABER, JOEL H (contact)

PROJECT_TERMS: Advisory Committees;Age;Aging;analysis pipeline;Applications Grants;ATAC-seq;Bioinformatics;bioinformatics tool;Biological;Centers of Research Excellence;ChIP-seq;Cloud Computing;Collaborations;Communities;comparative;Comparative Biology;comparative genomics;Computational Technique;Computer Analysis;computerized data processing;Continuing Education;cost efficient;Data;data acquisition;Data Analyses;data curation;Data Files;data format;data management;data pipeline;Data Science;Data Science Core;Data Set;Development;Developmental Biology;Discipline;Education;empowerment;Ensure;epigenetic clock;Epigenetic Process;Evaluation;experience;Experimental Designs;experimental study;Faculty;Fee Schedules;Fees;flexibility;functional genomics;Funding;Gene Expression;Generations;Genetic study;Genetic Transcription;Genetic Variation;genome sciences;genome-wide;genomic data;Genomics;Goals;Human Resources;Inflammatory;innovation;Institution;Investigation;large-scale imaging data;Maintenance;Mammals;member;Modification;multiple data types;Natural regeneration;Organism;Participant;Phase;Pilot Projects;programs;Proteomics;public repository;regenerative biology;Regenerative Medicine;Regenerative research;repository;Reproducibility;Research;Research Personnel;Resources;Scientist;Services;single-cell RNA sequencing;Statistical Data Interpretation;Students;success;Testing;tissue repair;Training;transcriptome sequencing;transcriptomics;Untranslated RNA;Update;Visit;Work;Yeasts

PROJECT_TITLE: Comparative Genomics and Data Science Core


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD);Regenerative Medicine

PI_NAMEs: BONNET, FREDERIC XAVIER (contact)

PROJECT_TERMS: Aging;analysis pipeline;Applications Grants;base;bioimaging;Biological;Biosensor;cell behavior;Centers of Research Excellence;Collaborations;Comparative Biology;Computer software;Confocal Microscopy;Core Facility;Custom;Data;data management;Data Scientist;data submission;design;digital imaging;Education;Educational workshop;Faculty;falls;Fees;Funding;Generations;Goals;graduate student;Grant;Image;Image Analysis;image processing;Imaging technology;in vivo;innovation;Institution;investigator training;Laboratories;Laser Scanning Confocal Microscopy;Leadership;Light;Light Microscope;light microscopy;Lighting;live cell imaging;Maine;Microscope;Microscopic;microscopic imaging;Microscopy;model organism;mRNA Expression;Natural regeneration;optogenetics;Organism;Pilot Projects;Postdoctoral Fellow;programs;protein expression;Publications;recruit;Regenerative research;Reporter;repository;Research Assistant;Research Personnel;Research Project Grants;Resolution;Role;Scientist;Site;Structure;Students;symposium;System;Three-Dimensional Image;Three-Dimensional Imaging;tissue repair;Tissue Sample;Tissues;tool;Training;Training Programs;Travel;Visit;waiver

PROJECT_TITLE: Light Microscopy Facility Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Breast Cancer;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Drug delivery to brain tumors is hindered by the so-called “blood-tumor barrier”. It has been shown previously that this barrier to effective drug delivery may be overcome by injecting microbubbles into the bloodstream and then activating them with focused acoustic energy (i.e. focused ultrasound) as they pass through the tumor. In this project, we aim to further improve and refine this drug delivery approach by pre-treating brain tumors with pharmacological strategies that “normalize” tumor blood vessel structure and function so that they better synergize with focused ultrasound.

PI_NAMEs: PRICE, RICHARD J. (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: 4T1;Acoustics;Address;Aftercare;anergy;Angiogenesis Inhibitors;Animals;anti-PD-1;Antitumor Response;Blood - brain barrier anatomy;Blood capillaries;Blood Circulation;Blood Vessels;blood-brain tumor barrier;Brain;Brain Neoplasms;breast cancer metastasis;Cancer Patient;Cancer Prognosis;CD8-Positive T-Lymphocytes;Cell Adhesion Molecules;Cephalic;cerebral capillary;Cessation of life;chemotherapy;Clinical Treatment;Clinical Trials;Contrast Media;DC101 Monoclonal Antibody;design;Diameter;Disease;Dose;Drug Delivery Systems;Drug Modelings;Endothelial Cells;Endothelium;Exposure to;Focused Ultrasound;Generations;Glioblastoma;Glioma;Histologic;image guided;immune cell infiltrate;Immunoglobulin G;Immunotherapy;improved;Institution;interstitial;KDR gene;Life Expectancy;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of lung;Mammals;Maps;Mechanical Stress;Mediating;Melanoma;Metastatic malignant neoplasm to brain;meter;Microbubbles;Modeling;Monoclonal Antibodies;MultiHance;Neoplasm Metastasis;Neoplasms in Vascular Tissue;novel therapeutics;Operative Surgical Procedures;Patients;Penetration;Perfusion;Permeability;Pharmaceutical Preparations;pharmacologic;Physiologic pulse;preclinical study;pressure;Primary Brain Neoplasms;Primary Neoplasm;Property;Publishing;Radiation therapy;Regimen;Regional Perfusion;Reporting;response;small molecule;spatiotemporal;standard of care;Structure;subcutaneous;success;synergism;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;Tight Junctions;Time;Translating;Treatment Efficacy;Treatment Protocols;tumor;tumor growth;tumor microenvironment

PROJECT_TITLE: Augmenting focused ultrasound-mediated drug delivery to brain tumors with vascular normalization

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (M2)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: LARAMIE

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: This project studies the prefrontal microcircuit changes during normal aging and disease progression of Alzheimer's Disease (AD). This project will establish an integrative framework that quantitatively bridges empirical recordings and computational models to facilitate development of new effective treatment for AD.

PI_NAMEs: CHEN, RONG ;LI, YUN  (contact);LIU, RONGSONG

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: aged;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Animals;awake;behavior prediction;Behavioral;Brain;Brain region;Calcium;cohort;Color;Communities;Computer Models;Computer Simulation;Computer software;computer studies;Data;data modeling;Data Set;Dementia;Development;Disease Progression;effective therapy;excitatory neuron;Experimental Models;Functional Magnetic Resonance Imaging;Goals;Graph;graph theory;healthy aging;Image;imaging study;Impaired cognition;in vivo calcium imaging;indexing;inhibitory neuron;interdisciplinary approach;Intervention;life span;meetings;Methodology;Methods;Modeling;models and simulation;Mus;neural;normal aging;open source;Pathogenesis;Pathology;Pathway Analysis;Performance;Phase;Prefrontal Cortex;Process;Sampling;scale up;simulation;supervised learning;Time;Visualization

PROJECT_TITLE: Integrating Experimental and Computational Models to Study the Prefrontal Microcircuit Changes During Aging and Alzheimer's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE There is increasing recognition that traumatic brain injury (TBI) is a risk factor for progressive neurodegeneration. In order to study how TBI can induce long-term and evolving pathological processes, we propose to develop novel preclinical models of TBI that replicate both the brain pathologies and progressive cognitive deficits seen in some TBI patients. Generating relevant and validated models will be critical for advancing our understanding of TBI-related neurodegeneration and developing novel therapeutic interventions.

PI_NAMEs: JOHNSON, VICTORIA ELEANOR (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease related dementia;Anatomy;Archives;Automobile Driving;Autopsy;Behavioral;Biological Markers;Biomechanics;Blood;Brain;Brain Concussion;Brain hemorrhage;Brain Injuries;Brain Pathology;Chronic;Chronic Phase;chronic traumatic encephalopathy;Clinical;Clinical Data;clinical phenotype;clinically relevant;Cognitive deficits;cognitive testing;Complex;Consensus;contact sports;Data;dementia risk;Development;Diffuse;Ensure;epidemiologic data;Epidemiology;Evolution;Face;Family suidae;Feedback;functional decline;functional outcomes;Gene Modified;Histologic;Human;Human Pathology;human tissue;hyperphosphorylated tau;Impaired cognition;Individual;Injury;insight;Institution;iterative design;Knowledge;life span;Long-Term Effects;Measurement;mild traumatic brain injury;Modeling;Nature;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;neuroimaging;neuroimaging marker;Neurons;neuropathology;novel;novel diagnostics;novel therapeutic intervention;Outcome;Pathogenesis;Pathologic Processes;Pathology;Pathology Report;porcine model;Pre-Clinical Model;progressive neurodegeneration;Recovery;Reporting;Reproducibility;Risk;Risk Factors;Rodent Model;Role;Serum;Site;Specific qualifier value;Sports;Standardization;success;tau Proteins;Tauopathies;TBI Patients;Therapeutic Intervention;Tissue Sample;touchscreen;Transgenic Organisms;translational study;Traumatic Brain Injury;Validation;Vascular Diseases;white matter;Work

PROJECT_TITLE: Developing Gyrencephalic Models of TBI-Induced ADRD Neuropathology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Cerebrovascular;Dementia;Headaches;Migraine;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Pain Research

ORG_CITY: TAMPA

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The oligomeric forms of Aβ40 and Aβ42 are considered as the primary toxic agents in the etiology of Alzheimer’s disease (AD). Thus, determining the conditions that promote Ab aggregation in the brain is crucial to understanding the pathogenesis of AD and identifying new therapeutic targets. We will use novel approaches in multiscale modeling, high resolution microscopy, antibody staining, and measurement of paralysis phenotype to determine the role of the drastic physiochemical changes and metabolic stress associated with pathological states such as stroke, traumatic brain injury, and migraine in the onset and progression of Aβ40 and Aβ42 aggregation in the brain.

PI_NAMEs: MUSCHOL, MARTIN ;ULLAH, GHANIM  (contact);WESTERHEIDE, SANDRA D.

PROJECT_TERMS: abeta accumulation;abeta oligomer;Acceleration;Affect;Alzheimer's Disease;Amyloid beta-42;Amyloid beta-Protein;amyloid formation;Aneurysmal Subarachnoid Hemorrhages;Antibodies;Astrocytes;ATP phosphohydrolase;biophysical model;Brain;Brain region;Caenorhabditis elegans;Cell membrane;Cells;Chronic;Complex;computational neuroscience;Cytoplasm;Data;Down-Regulation;Etiology;Event;Evolution;experimental study;extracellular;Extracellular Space;Fluorescence;Frequencies;high resolution imaging;Homeostasis;Human;In Vitro;in vivo;innovation;Ion Channel;ion dynamics;Ionic Strengths;Ions;Ischemic Stroke;Kinetics;Link;Lysosomes;Markov Chains;Measurement;Metabolic stress;meter;Microscopy;Migraine;Modeling;Molecular Conformation;monomer;Monte Carlo Method;Morphology;multi-scale modeling;Muscle Cells;nanometer;nanosecond;Nature;Neurons;neurovascular coupling;new therapeutic target;novel strategies;Optics;Oxygen;Paralysed;Pathogenesis;Pathologic;Pathology;Peptides;Phenotype;Physiological;Population;predictive modeling;pressure;Recurrence;Resolution;Risk Factors;Role;Scheme;Sodium Chloride;spatiotemporal;Spectrum Analysis;Stains;Stroke;Swelling;Techniques;Testing;Tissues;Toxic effect;Traumatic Brain Injury

PROJECT_TITLE: Investigating the aggregation of amyloid β during metabolic stress using multiscale modeling


NIH_SPENDING_CATS: Cancer

ORG_CITY: DALLAS

ORG_DEPT: SURGERY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: This T32 application describes a comprehensive recruitment, training and retention program that combines a strong basic science curriculum with a strong translational cancer focus that distinguishes it from other training programs. Our goals are to train top-quality scientists capable of conducting independent cancer research; foster the intellectual, technical and communication skills required to succeed in the academic or industrial arenas of today and in the future; and to provide an understanding of the basic, public health, and clinical problems of human cancer. The Cancer Center Director of our NCI Designated Comprehensive Cancer Center provides substantial financial support for education and training.

PI_NAMEs: BREKKEN, ROLF A (contact);SHAY, JERRY WILLIAM

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Cancer Biology;Training Programs

PROJECT_TITLE: Translational Cancer Biology (TCB) T32 Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Genetics

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

PHR: Project Narrative Research using the amphibian Xenopus, because of unique advantages as an experimental system, has revealed key insights in many domains of biomedical research, including cell biology, development, neurobiology, physiology and signal transduction. This proposal seeks to generate and characterize different Xenopus mutants in key genes related to human diseases using new technology, which will help provide significant insights about the causes of these diseases.

PI_NAMEs: HORB, MARKO E (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Agreement;Amphibia;Animals;base editing;Base Pairing;Biological Models;Biomedical Research;biomedical resource;Breeding;Cellular biology;Chimeric Proteins;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;cost;Data;Destinations;Development;Developmental Biology;Diploidy;Disease;DNA;Embryo;Emerging Technologies;Ensure;experimental study;Funding;gene-editing approach;Generations;Genes;Genetic;Genetic Models;genome editing;Goals;Grant;Heritability;Human;human disease;human model;improved;Individual;Infrastructure;insight;Investments;Knock-in;meetings;Modeling;mutant;Mutation;Neurobiology;new technology;Oocytes;Paper;Physiology;Proteins;R24;repaired;Research;Research Personnel;Resources;response;Scientist;Signal Transduction;site-specific integration;System;Testing;Time;Tissues;Training;Transgenic Organisms;United States National Institutes of Health;water quality;Work;XenBase;Xenopus

PROJECT_TITLE: Xenopus Mutant Resource

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-E (55)]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Furthering the ongoing fight against cancer requires scientists who can communicate across traditionally distinct research disciplines such as epidemiology, biostatistics, genetics, -omics, and environmental health— while ensuring that advances are undertaken in an appropriate manner toward reducing disparities. The proposed T32 program will fulfill this need by providing exceptional training to prepare predoctoral students in the integration of innovative methods and cancer research questions in a cross-cutting transdisciplinary and translational manner. Graduates of the program will have the expertise to work in multidisciplinary teams and be tomorrow’s cancer research leaders.

PI_NAMEs: BONDY, MELISSA L.;WITTE, JOHN S. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: cancer health disparity;cancer risk;Genetic

PROJECT_TITLE: Genetic and Environmental basis of Cancer Risk and Disparities (GECaRD)


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Unfortunately, survival following lung transplantation is the worst amongst solid organs with only 80% and 50% of patients alive at 1 and 5 years, respectively. Acute and chronic rejection, known as primary graft dysfunction (PGD) and chronic lung allograft rejection (CLAD) are the major drivers of these poor outcomes. The PPG investigators seek to identify common mechanisms that cause PGD and CLAD in mouse models and in patients with a goal of identifying new treatments that will improve survival for lung transplant recipients.

PI_NAMEs: BHARAT, ANKIT  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acids;Acute;Affect;airway epithelium;allograft rejection;alveolar epithelium;Alveolar Macrophages;aspirate;Attenuated;biological adaptation to stress;Biological Assay;Biological Markers;Biopsy Specimen;Bronchoalveolar Lavage Fluid;Cells;Chronic;Clinical;Clinical Data;clinical phenotype;cohort;Communities;Complement Activation;Complex;COVID-19 pandemic;Credentialing;CSF1 gene;CSF1R gene;Data;Detection;Epithelial Cells;epithelial repair;Esophagus;follow-up;Functional disorder;Gastroesophageal reflux disease;Genetic;Goals;graft dysfunction;Hour;Human;Immune;improved;innovation;Isoantibodies;Life;Link;Lung;lung allograft;lung development;Lung Diseases;lung injury;lung repair;Lung Transplantation;Mediating;Medical;Methods;Mitochondria;mitochondrial dysfunction;Molecular;monocyte;mortality;mouse model;multiple omics;Mus;Nature;neutrophil;Neutrophil Infiltration;Organ;Outcome;Pathologic;Pathway interactions;Patients;Phenotype;Physiological;Physiology;Procedures;programs;Publishing;Pulmonary Fibrosis;Reagent;recruit;Refractory;Reproducibility;Research Personnel;Risk Factors;Salvage Therapy;severe COVID-19;Severities;small molecule inhibitor;Solid;Stomach;synergism;Testing;therapeutic target;Tissue Sample;Transplant Recipients;Transplantation;Universities

PROJECT_TITLE: Integrated mechanisms of primary and chronic graft dysfunction following lung transplantation

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP (MA)]


PROJECT_TERMS: Accountability;adaptive immunity;Advisory Committees;Chest;Chronic;clinically actionable;Collaborations;collaborative environment;Communication;Communities;Data;data sharing;Ensure;Environment;Expenditure;Faculty;FAIR principles;Fostering;Funding Opportunities;Goals;graduate student;graft dysfunction;Hybrids;Infrastructure;innovation;Institution;Interdisciplinary Study;Lung;Lung Transplantation;meeting abstracts;meetings;member;Mentors;Monitor;National Heart, Lung, and Blood Institute;Natural Immunity;next generation;Notification;Persons;Physicians;Postdoctoral Fellow;Preparation;Program Research Project Grants;programs;Protocols documentation;public database;Publications;Recording of previous events;repository;Research;Research Personnel;Resources;Scientist;Site;Structure;student mentoring;Thoracic Surgical Procedures;Training;Translational Research;Transplant Surgeon;Transplantation Immunology;web site;Work

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Data Science;Genetics;Human Genome;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Organ Transplantation;Precision Medicine;Transplantation

PI_NAMEs: SINGER, BENJAMIN DAVID (contact)

PROJECT_TERMS: adjudication;Atlases;biobank;Biocompatible Materials;Biological;Biological Assay;biomarker identification;Bronchoscopy;Caring;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chronic;Clinical;clinical care;Clinical Data;clinical phenotype;clinical predictors;Clinical Research;Collaborations;Collection;Complement;Credentialing;Cryopreservation;Data;data integration;Data Science;Data Set;Development;Diagnosis;Electronic Health Record;Enrollment;Esophagogastroduodenoscopy;Esophagus;Event;experience;Flow Cytometry;Functional disorder;Genomics;Goals;graft dysfunction;Hour;Human;human tissue;Immunologics;Immunophenotyping;improved;insight;Institutional Review Boards;Laboratories;large scale data;Life;Link;Liquid substance;longitudinal care;Lung;lung allograft;Lung Diseases;Lung Transplantation;Machine Learning;Manuals;Medicine;metabolomics;Modeling;molecular phenotype;Morbidity - disease rate;mortality;Multiomic Data;next generation sequencing;novel;Observational Study;organ transplant recipient;Outcome;participant enrollment;Pathogenesis;Pathway interactions;Patients;Phenotype;phenotypic data;Play;post-transplant;Pre-Clinical Model;Procedures;Process;prospective;Proteomics;Protocols documentation;Research;Research Personnel;Risk;Role;sample collection;Sampling;scaffold;single-cell RNA sequencing;Solid;Survival Rate;Suspensions;Testing;Therapeutic;therapeutic target;Time;Tissue Banks;tissue fixing;Tissues;transcriptomic profiling;transcriptomics;transfer learning;Transplant Recipients;Transplantation;Work

PROJECT_TITLE: Core B: Human and Clinical Phenotyping Core


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Lung;Organ Transplantation;Pulmonary Fibrosis;Transplantation

PI_NAMEs: RIDGE, KAREN M (contact)

PROJECT_TERMS: allograft rejection;Allografting;Animals;Bioinformatics;Biological Assay;Breeding;Caring;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;central database;Chronic;Clinical;clinical risk;Collaborations;Communities;Complex;conditional knockout;Data;Development;DNA Methylation;Emerging Technologies;Event;experience;experimental study;Flow Cytometry;Functional disorder;Generations;Genetic;Genetically Engineered Mouse;Genotype;Goals;graft dysfunction;Hour;Human;human tissue;Image;immune cell infiltrate;improved;in vivo;Incidence;Individual;Inflammatory;insight;Knock-out;Laboratories;Life;Link;live cell imaging;Lung;lung allograft;Lung Diseases;lung injury;Lung Transplantation;Measurement;Measures;metabolomics;microbiome analysis;Minor Histocompatibility Antigens;Modeling;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;mouse model;multiple omics;Mus;novel;Operative Surgical Procedures;organ transplant recipient;Outcome;overexpression;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phenotype;Play;Population;post-transplant;Premature Mortality;Process;Proteins;Proteomics;Protocols documentation;Publishing;Pulmonary Fibrosis;Pulse Oximetry;Reporter;Research;Research Personnel;Resources;response;Risk;Risk Factors;Role;single-cell RNA sequencing;Solid;Strategic Planning;Structure of parenchyma of lung;targeted treatment;Techniques;Technology;technology platform;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;Transgenic Organisms;transplant model;Transplant Recipients;Transplantation;whole genome;Work

PROJECT_TITLE: Core C: Mouse and Cell Phenotyping Core


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Lung;Organ Transplantation;Transplantation

PROJECT_TERMS: Acids;Acute;Affect;allograft rejection;Allografting;Alveolar;Alveolar Macrophages;antigen binding;Antigen-Antibody Complex;Antigens;aspirate;Attenuated;Autoantibodies;Autoantigens;Binding;Biological Assay;Caring;CCL2 gene;Cells;Chronic;Chronic lung disease;Clinical;clinical application;Clinical Research;Collaborations;Collagen Type V;Complement;Complement Activation;CXCL2 gene;Data;Development;end stage disease;Endothelium;Epithelium;Epitope spreading;Epitopes;Esophagus;Extracellular Matrix Proteins;Extravasation;Fc Receptor;Functional disorder;graft dysfunction;Hour;Immune;immunogenic;improved;Industry Collaboration;Injury;insight;Interleukin-1 beta;Intervention;Life;Ligation;Link;Lung;lung allograft;lung injury;Lung Transplantation;Matrix Metalloproteinases;Mediating;Methods;migration;mitochondrial dysfunction;Modeling;Molecular;monocyte;mortality;mouse model;Mus;neutrophil;Neutrophil Collagenase;Neutrophil Infiltration;Organ;Organ Transplantation;Outcome;Pathogenesis;Pathologic;Pathway interactions;Patient Care;Patients;Pattern;Permeability;PIK3CG gene;Postoperative Period;prevent;Production;prospective;Publishing;recruit;repaired;Research Personnel;Resolution;Risk;Role;Severities;Signal Pathway;Signal Transduction;Solid;Testing;TLR2 gene;Translating;Transplant Recipients;Transplantation;Tubulin;Work

PROJECT_TITLE: Synergistic roles of lung autoantibodies, donor nonclassical monocytes and recipient classical monocytes in mediating primary graft dysfunction


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Lung;Organ Transplantation;Transplantation

PI_NAMEs: PERLMAN, HARRIS R (contact)

PROJECT_TERMS: Acids;Acute;Allografting;Alveolar Macrophages;Anesthetics;Antigens;aspirate;Autoantibodies;Autoantigens;Automobile Driving;Bolus Infusion;Cells;Chronic;Chronic lung disease;Clinical;clinically actionable;clinically relevant;Credentialing;Data;Deglutition;Development;donor-specific antibody;electric impedance;epithelial repair;Epithelium;Epitope spreading;Esophagogastroduodenoscopy;Esophagus;Event;Four-dimensional;Functional disorder;Fundoplication;Future;Gastroesophageal reflux disease;Generations;Goals;graft dysfunction;high dimensionality;Hour;Human;human subject;Immunologics;improved;Incidence;indexing;Injury;innovation;insight;large datasets;Link;Lung;lung allograft;lung development;Lung Transplantation;Manometry;Medical;mitochondrial dysfunction;Molecular;monocyte;mouse model;Mus;neutrophil;Neutrophil Infiltration;novel;Operative Surgical Procedures;Outcome;Pathogenesis;Pathologic;Pathway interactions;patient stratification;Patients;Peristalsis;Pharmacotherapy;Physiological;Prevalence;prevent;Procedures;programs;Proton Pump Inhibitors;Recommendation;Reflux;Research;Research Personnel;Resolution;Respiration;response;Risk;Risk Factors;Role;Sampling;secondary outcome;Series;Stomach;Stomach Content;Testing;Transplant Recipients;Transplantation

PROJECT_TITLE: Physiologic and molecular mechanisms linking gastroesophageal reflux with chronic lung allograft dysfunction


NIH_SPENDING_CATS: Clinical Research;Lung;Organ Transplantation;Pulmonary Fibrosis;Rare Diseases;Transplantation

PI_NAMEs: MISHARIN, ALEXANDER  (contact)

PROJECT_TERMS: Ablation;Allografting;Alveolar Macrophages;aspirate;autocrine;Biological Assay;Biological Markers;Bronchiolitis Obliterans;Bronchoscopy;Caring;cell type;Cells;Chronic;Clinical;clinical phenotype;Credentialing;CSF1 gene;CSF1R gene;Data;data integration;Development;Disease;Disease Progression;effective therapy;Electronic Health Record;Epithelium;Esophagus;experimental study;Fibroblasts;fibrotic lung disease;Flow Cytometry;Functional disorder;Gastroesophageal reflux disease;Gene Expression Profile;Genetic;graft dysfunction;Human;improved;Injury;Life;Liquid substance;Lung;lung allograft;Lung Diseases;Lung Transplantation;Machine Learning;Macrophage;Maintenance;Metabolic;Methodology;mitochondrial dysfunction;Modeling;Molecular;Molecular Analysis;monocyte;Morbidity - disease rate;mortality;mouse model;nano-string;neutrophil;Neutrophil Infiltration;new therapeutic target;organ transplant recipient;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;pharmacologic;Play;Population;post-transplant;predictive marker;prevent;Procedures;Publishing;Pulmonary Fibrosis;recruit;Regimen;Regulatory T-Lymphocyte;response;Role;Sampling;Severities;Signal Transduction;single cell analysis;single-cell RNA sequencing;Solid;Source;standard of care;Syndrome;T-Lymphocyte;Testing;Therapeutic;transcriptomics;Transplant Recipients;Transplantation;Work

PROJECT_TITLE: Crosstalk between profibrotic monocyte-derived macrophages and T cells in the pathobiology of CLAD


NIH_SPENDING_CATS: Clinical Research;Genetics;Lung;Organ Transplantation;Pulmonary Fibrosis;Transplantation

PI_NAMEs: HAN, SEUNGHYE  (contact)

PROJECT_TERMS: Acids;Adult;AGTR2 gene;airway epithelium;Allografting;Alveolar;alveolar epithelium;Alveolar Macrophages;Asbestos;aspirate;Attenuated;biological adaptation to stress;Biopsy;Bleomycin;Cell Cycle Arrest;cell type;Cells;Characteristics;Chronic;Complex;Credentialing;Cytokeratin;Development;Electron Transport;Epithelial Cells;epithelial injury;epithelial repair;Epithelium;experimental study;extend lifespan;Failure;Fibroblasts;Fibrosis;Functional disorder;Gene Expression Regulation;Genes;Genetic Models;Genetic Transcription;Goals;graft dysfunction;Human;Immune;immune activation;Immunosuppression;Impairment;improved;Injury;Interruption;Intervention;Knock-out;Link;Lung;lung allograft;lung development;Lung Diseases;lung injury;Lung Transplantation;Mediating;Metabolism;metabolomics;Mitochondria;Mitochondrial complex I deficiency;mitochondrial dysfunction;Mitochondrial Electron Transport Complex I;Modeling;monocyte;mouse model;Mus;Natural regeneration;Nature;novel;Organ Transplantation;Outcome;overexpression;Paper;Pathologic;Patients;Population;postnatal;postnatal development;prevent;Process;Profibrotic signal;programs;Publishing;Pulmonary Fibrosis;pulmonary function;Quality of life;recruit;repaired;Reperfusion Injury;Reporting;Resolution;restoration;Sampling;Series;Severities;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;Solid;targeted treatment;Testing;Therapeutic;transcriptome sequencing;Transitional Cell;Translational Repression;Transplant Recipients;Transplantation;Up-Regulation

PROJECT_TITLE: Mitochondrial integrated stress response and lung allograft dysfunction


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: Narra$ve We propose to use a “Team-Science”-based two-phase approach towards the development of a robust murine model of TBI-induced ADRD phenotype. In Phase 1, we will examine and screen for mouse strain determinants and TBI injury types that might favor post TBI-ADRD formation and progression. In Phase 2, using the selected mouse strain/injury model candidate, we will introduce and evaluate two TBI-ADRD model enrichment factors.

PI_NAMEs: WANG, KEVIN KA WANG (contact)

PROJECT_TERMS: Acceleration;Acute Brain Injuries;Address;Affect;Age;Alzheimer's disease related dementia;Animal Model;Basic Science;Biological Assay;Biological Markers;biomarker signature;Brain;Characteristics;clinically relevant;Closed head injuries;Cognitive deficits;college;Common Data Element;controlled cortical impact;Data;Data Collection;design;Development;Disease Progression;Ensure;experience;Experimental Designs;Human;improved;Injury;Laboratories;life span;Link;Memory impairment;Methods;Microglia;Modeling;Molecular;Morehouse School of Medicine;mouse model;Mouse Strains;multidisciplinary;multiple omics;Mus;mutant;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Nervous System Trauma;neurobehavioral;Neurocognitive;neurodegenerative phenotype;neuroinflammation;neuropathology;operation;overexpression;Pathogenesis;Pathologic;Pathway interactions;pharmacologic;Phase;Phenotype;pre-clinical;presenilin;Probability;Procedures;protein aggregation;Publishing;Reproducibility;Research;Research Personnel;Resources;Rodent;Role;Science;Site;Standardization;symposium;tau Proteins;Testing;Texas;Therapeutic;Transgenic Mice;Transgenic Organisms;Translational Research;transmission process;Validation;Washington

PROJECT_TITLE: TBI-ADRD Modeling with a Team Science Approach (TBI-ADRD Team Science)


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences

ORG_CITY: WASHINGTON

ORG_NAME: SOCIETY FOR NEUROSCIENCE

ORG_STATE: DC

PHR: PROJECT NARRATIVE By supporting diverse neuroscientists at multiple career stages, the Neuroscience Scholars Program (NSP) fosters and grows a diverse neuroscience workforce that will efficiently address a breadth of difficult research questions and adopt approaches that may not be envisioned by groups with more homogeneous backgrounds and training. Such a diverse, well-trained neuroscience workforce is instrumental to making new discoveries about how the brain works and to finding innovative ways to prevent and treat neurological illnesses and disorders that account for a greater burden than any other group of diseases (Kaji, 2019). Diversity in the neuroscience workforce also ensures that research discoveries apply to a broader spectrum of the U.S. population; involving researchers from underrepresented groups increases attention to and research on health disparities and otherwise-neglected issues specific to women’s health and those of diverse populations (Ovbiagele, 2023).

PI_NAMEs: ALVINA, KARINA ;POE, GINA R;ROSA-MOLINAR, EDUARDO  (contact)

PROGRAM_OFFICER_NAME: JONES, MICHELLE

PROJECT_TERMS: Academia;Acceleration;Address;Adopted;Advocate;Area;Attention;base;behavioral health;Behavioral Sciences;Brain;burden of illness;career;Career Choice;clinically significant;cohort;Collaborations;Communities;Complex;COVID-19 pandemic;culturally appropriate intervention;curriculum development;Development;digital;Disease;disparity reduction;Diverse Workforce;Education;Educational Curriculum;empowerment;Ensure;Environment;Evaluation;Event;experience;Face;Faculty;Fostering;Funding;General Population;graduate student;Growth;hands on research;health disparity;health inequalities;improved;Individual;innovation;Institution;Interest Group;Knowledge;Leadership;leadership development;Libraries;Longevity;meetings;Mental Health;Mentors;Mentorship;Methods;Modality;neglect;Neurologic;Neurological outcome;Neurosciences;Neurosciences Research;next generation;Participant;peer;peer coaching;Persons;podcast;Population;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;prevent;Process;programs;racism;Research;Research Personnel;Resources;role model;Scholars Program;Series;skill acquisition;skills;Societies;Structure;success;System;Training;Translating;Travel;treatment and outcome;treatment disparity;Underrepresented Populations;United States National Institutes of Health;Update;Veins;virtual;Women's Health;Work

PROJECT_TITLE: Neuroscience Scholars Program (NSP): Preparing the Next Generation of Neuroscience Leaders

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-L (25)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease

ORG_NAME: LADERX LLC

PHR: PROJECT NARRATIVE Coronary artery disease is the most common type of heart disease (1 in 20 people age 20 or older have CAD) and is the leading cause of mortality in the US. LadeRx is developing a chelated manganese-based contrast agent which will enable quantitative myocardial perfusion imaging with concomitant high-resolution anatomical data in a single MRI exam. This will substantially improve the management of patients with coronary artery disease, particularly patients with multivessel disease and patients with renal-impairment.

PI_NAMEs: SONG, ALLEN W (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: accurate diagnosis;Acute;Adenosine;Advanced Development;Affect;Age;Aging;Anatomy;Animals;Atherosclerosis;Biodistribution;Biological;bisphosphonate;Blood;Blood flow;blood flow measurement;Blood Vessels;Brain;Cardiac;Cells;chelation;Chronic Kidney Insufficiency;Clinical;clinical practice;clinically relevant;Complex;contrast enhanced;Contrast Media;Coronary Angiography;Coronary Arteriosclerosis;Coronary Vessels;Data;Deposition;diagnostic accuracy;Diffuse;Diffusion;Disease;Dose;Drug Kinetics;Evaluation;Gadolinium;Gallbladder;Half-Life;Heart;Heart Diseases;Human;Imaging Techniques;Impairment;improved;Inductively Coupled Plasma Mass Spectrometry;interstitial;intravenous administration;Ischemia;Kidney;Kidney Diseases;kinetic model;Ligands;Link;Liver;Magnetic Resonance Imaging;Manganese;manufacture;Maps;Measurement;Microspheres;Modeling;mortality;mouse model;Mus;Myocardial;Myocardial perfusion;Names;novel;nuclear imaging;Organ;Outcome;Pathway interactions;Patients;perfusion imaging;Persons;pharmacologic;Pharmacologic Substance;Phase;radiotracer;Rattus;Regional Perfusion;Resolution;Rest;safe patient;Safety;Signal Transduction;single photon emission computed tomography;Small Business Technology Transfer Research;Stress;Techniques;Testing;Therapeutic;Time;Tissues;Toxic effect;Toxicology;uptake;Work

PROJECT_TITLE: Manganese-based MRI contrast agent for quantitative myocardial perfusion imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-S (13)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: FAIRFAX

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: GEORGE MASON UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant for public health because the expected outcome of the proposed experiments is a full-scale spiking neural network model that will help explore the mechanisms of brain aging on the storage and retrieval of memories. Innovative experiments will investigate the contribution of fast temporal dynamics of the neurotransmitter acetylcholine on modulating encoding and retrieval states and their changes during aging in live behaving subjects. The project is relevant to NIA’s mission because the expected results will contribute to our mechanistic understanding of how age-related changes in cholinergic modulation can result in maladaptive network activity and ultimately age-related decline in memory.

PI_NAMEs: ASCOLI, GIORGIO A;DANNENBERG, HOLGER  (contact)

PROJECT_TERMS: Acetylcholine;Age;age effect;age group;age related;age related changes;age related decline;Aging;aging brain;Alzheimer's Disease;Animal Behavior;Area;Behavior;Behavioral;Biophysics;Body Weight Changes;cell type;cholinergic;Cholinergic Receptors;cognitive function;comparative;Complex;Computer Models;Data;Data Set;data-driven model;Development;Elderly;Episodic memory;Event;experimental study;Fiber;Formulation;Fostering;Frequencies;Goals;Hippocampus;Impaired cognition;Impairment;in silico;in vivo;Individual;innovation;Investigation;Learning;Location;Memory;memory encoding;Memory impairment;Memory Loss;memory retrieval;Mental Depression;Mission;model design;Modeling;Modification;Mus;Muscarinic Acetylcholine Receptor;Muscarinics;neural;neural circuit;neural network;Neural Network Simulation;Neurons;neuroregulation;Neurotransmitters;Nicotinic Receptors;novel;old mice;operation;optogenetics;Outcome;Pattern;Performance;Periodicity;Phase;Photometry;Population;prevent;Process;Public Health;Research;Resolution;Retrieval;Risk Factors;Role;septohippocampal;simulation;spatial memory;Synapses;Testing;young adult

PROJECT_TITLE: From functional to dysfunctional neural network dynamics underpinning memory storage and retrieval across young adult and aged mice


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Contraception/Reproduction;Prevention;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Currently, research curricula and mentorship specific to Sexual and Reproductive Health, Rights and Justice (SRHRJ) topics, and Community-Engaged Research (CER) methods are lacking in consistency and accessibility across academic institutions, disciplines, and training levels. The University of Utah-based ASCENT Center for Reproductive Health is poised to address this through the creation of the ASCENT Research Training Program SRHRJ open to scholars nationwide from upper undergraduates to professional level. Ultimately, this program and resulting toolkit will increase accessibility to advanced CER techniques, enhance the training experience, and support professional and career development for a new generation of diverse SRHRJ scholars.

PI_NAMEs: SANDERS, JESSICA N (contact);TUROK, DAVID

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Award;Behavioral Research;Biomedical Research;career;career development;career networking;Child;Clinical;Clinical Research;cohort;Collaborations;Communities;community engaged research;community engagement;community partnership;Dedications;design;Development;Discipline;Diverse Workforce;Economics;Education;Education Projects;education research;Educational Curriculum;Educational Status;Emotional;Ensure;Equity;Ethics;Evaluation;experience;Family Planning;Freedom;Funding;Future;Gender;Generations;Goals;graduate student;hands on research;Health;health disparity;Health Services Accessibility;Human Rights;Immersion;Individual;Infrastructure;innovation;Institution;interest;Intervention;Justice;Knowledge;Legal;life span;Medical Students;Medicine;Mentors;Mentorship;Modeling;National Institute of Child Health and Human Development;novel;Nursing Students;Parents;Pathway interactions;Persons;Policies;Policy Research;Politics;programs;Psyche structure;racism;recruit;Reproduction;reproductive;Reproductive Health;Reproductive Rights;Research;Research Methodology;Research Personnel;Research Technics;Research Training;Resources;Rights;Scholars Program;Services;sexual and reproductive health;Sexual Health;simulation;skills;social stigma;Societies;summer research;symposium;System;Training;Training and Education;training opportunity;Training Programs;Translational Research;Travel;Trust;undergraduate student;Underrepresented Populations;Universities;Utah;Vision;Woman

PROJECT_TITLE: Research Training Program in Reproductive and Sexual Health

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE A hallmark of human intellect is our ability to flexibly manipulate information in working memory and for language to apply meaning to it, however the neuronal mechanisms supporting this uniquely human neural entanglement remain poorly understood from cellular to systems levels. The proposed interdisciplinary team will pursue a transformative understanding of working memory and language interactions by leveraging high-density laminar array recordings in neurosurgery patients during their operating room treatment procedures—allowing access to single units and local-field potentials distributed across cortical layers—complemented by unprecedented single-cell genomic and spatial transcriptomic insights from tissue samples after task performance and the array recordings. High-resolution laminar fMRI will be pre-operatively obtained in the same patients and with the same task to allow investigating system-wide interactions, and the combined datasets will be integrated across scales with a next-generation biophysical model to advance mechanistic understanding of human laminar circuit motifs and how working memory and language interact to organize and give meaning to our inner thoughts.

PI_NAMEs: PETKOV, CHRISTOPHER I (contact);VALIANTE, TAUFIK A;YACOUB, ESSA

PROGRAM_OFFICER_NAME: GEBREHIWET, HERMON RUSSOM

PROJECT_TERMS: Acceleration;Affect;Animal Model;Animals;Anterior;Architecture;Area;Behavior;Behavioral;biophysical model;Biophysics;Brain;Cells;Characteristics;Clinical Treatment;Cognition;cognitive function;combinatorial;Combinatorics;comparison control;Complex;Data;Data Set;Deep Brain Stimulation;density;Disease;Distant;Electrodes;Electroencephalography;Electrophysiology (science);Epilepsy;Excision;Feedback;first-in-human;flexibility;Functional Magnetic Resonance Imaging;Health;Human;human model;Inferior frontal gyrus;insight;Institutional Review Boards;Intelligence;Investigation;Joints;Knowledge;Language;Language Disorders;Memory;Mind;Modeling;Monitor;Motor Cortex;multi-scale modeling;multimodal data;multiple omics;neocortical;neural;neuroimaging;Neurologic;neuromechanism;Neurons;neurophysiology;Neurophysiology - biologic function;neurosurgery;next generation;novel strategies;Nuclear;Operating Rooms;Outcome;Patients;predictive modeling;Prefrontal Cortex;Procedures;Process;programs;receptor;remote interaction;Research;Resolution;response;Sampling;Semantics;Sensory;sensory cortex;Short-Term Memory;Signal Transduction;single cell genomics;Site;System;Task Performances;Temporal Lobe;Testing;Thinking;Time;tissue processing;Tissue Sample;transcriptomics;treatment center;U-Series Cooperative Agreements

PROJECT_TITLE: Laminar Circuit Motifs for Working Memory and Language Combinatorics: From Cells to Systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-P (14)]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: OVERALL PROJECT NARRATIVE Yale Cancer Center (YCC) is committed to eliminating the burden of cancer through transformative research, with attention to the needs of all people facing this disease. Our goal is to understand and prevent cancer, detect cancer early, and manage cancer more effectively, while maximizing access to care, addressing the needs of the community, ensuring equity and diversity in our workplace, and training future cancer researchers, clinicians, and leaders.

PI_NAMEs: WINER, ERIC P (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Academia;Address;anti-cancer research;Area;Attention;Award;Back;Basic Cancer Research;Basic Science;Biological Markers;Cancer Burden;cancer care;Cancer Center Support Grant;cancer health disparity;cancer prevention;cancer therapy;career development;Caring;Catchment Area;Clinic;Clinical;clinical care;Clinical Sciences;Clinical Trials;Collaborations;combat;Communities;community involvement;Connecticut;design;Diagnosis;Direct Costs;Disease;Disparity;Disparity in diagnosis;disparity reduction;Diverse Workforce;diversity and equity;Dreams;Ensure;Equity;Fostering;Funding;Future;Goals;Grant;Health Services Accessibility;Heart;Improve Access;improved;Individual;Industry;innovation;Institution;Investments;Journals;Knowledge;Laboratories;Leadership;Link;Malignant Neoplasms;member;Mentors;NCI Center for Cancer Research;next generation;novel;novel therapeutic intervention;Outcome;Output;Patient Selection;Patients;Peer Review;Persons;Physicians;Population;Population Sciences;prevent;programs;Publications;Recording of previous events;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Scientist;Screening for cancer;Services;Source;Strategic Planning;synergism;Technology;therapy resistant;Training;Training and Education;Translating;Translational Research;Universities;Vision;Work;Workplace;Yale Cancer Center

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PHR: ADMINISTRATION – NARRATIVE Not applicable.

PI_NAMEs: KAFTAN, EDWARD  (contact)

PROJECT_TERMS: Address;Adopted;anti-cancer research;Area;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer health disparity;career development;Caring;Clinical Trials;Collaborations;Communication;community engagement;Community Outreach;Core Facility;Data;Database Management Systems;Databases;Development;Development Plans;Disparity;Equipment;Equity;Evaluation;Fostering;Funding;Future;Goals;Grant;improved;innovation;inter-institutional;Interdisciplinary Study;Investments;Journals;Leadership;Malignant Neoplasms;meetings;member;Mission;Monitor;Occupational activity of managing finances;operation;outreach;Paper;Play;Process;programs;Publications;Publishing;Reporting;Research;Research Infrastructure;Research Support;Reservations;Resource Sharing;Resources;Role;Sampling;Strategic Planning;System;Training;Training and Education;Translational Research;Update;Work;Yale Cancer Center

PROJECT_TITLE: Administrative Core


PHR: PLAN TO ENHANCE DIVERSITY – NARRATIVE Not applicable.

PI_NAMEs: ROGERS, FAYE A (contact)

PROJECT_TERMS: Address;Affinity;anti-cancer research;Awareness;Biomedical Research;Budgets;burnout;cancer care;Cancer Center Support Grant;cancer health disparity;cancer risk;career;career development;Caring;Catchment Area;Climate;Clinical;clinical practice;Clinical Research;Collaborations;college;Communication;Communities;community engagement;Community Outreach;Connecticut;cultural competence;design;Diverse Workforce;Education;Employee;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;Exposure to;Faculty;Fostering;Funding;Generations;Goals;Health;health disparity;Health Professional;Healthcare;Healthcare Systems;high school;improved;Individual;Inequity;Infrastructure;innovation;Institution;Investments;Knowledge;Leadership;learning progression;Malignant Neoplasms;medical schools;Medicine;member;Mentorship;Minority;Minority-Serving Institution;Mission;Modeling;next generation;novel;Oncology;operation;Outcome;outreach;Pathway interactions;Patient Care;Patients;Performance;Policies;Population;Population Heterogeneity;Productivity;programs;Racial Equity;recruit;Research;research faculty;Research Personnel;Role;satisfaction;Science;stem;Students;System;Talents;Therapeutic;Training;Training and Education;Trust;Underrepresented Populations;Universities;Vision;Voice;Woman;Work;Yale Cancer Center

PROJECT_TITLE: Plan to Enhance Diversity


PHR: CANCER RESEARCH TRAINING AND EDUCATION COORDINATION – NARRATIVE Not applicable.

PI_NAMEs: KLUGER, HARRIET M. (contact)

PROJECT_TERMS: Advisory Committees;American Cancer Society;anti-cancer research;Basic Science;Cancer Center Support Grant;cancer education;cancer research center director;Cancer Science;career;Career Choice;career development;Career Mobility;Catchment Area;Charge;Clinic;Clinical;Clinical Research;Clinical Sciences;Collaborations;college;Communities;community engagement;Community Outreach;design;Discipline;doctoral student;Education;Educational Activities;Educational process of instructing;Educational workshop;Elements;Ensure;Environment;Epidemiology;equity, diversity, and inclusion;Evaluation;experience;Faculty;Fertilization;Fostering;Funding;Goals;graduate student;Grant;Growth;Growth and Development function;high school;High School Student;Home;Immunooncology;improved;Individual;Infrastructure;Institution;interest;K-Series Research Career Programs;Leadership;leadership development;Learning;Malignant Neoplasms;medical schools;Medical Students;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;mid-career faculty;minority trainee;Mission;Monitor;NCI Center for Cancer Research;next generation;Nursing Students;Outcome;Outcomes Research;Pathway interactions;Physicians;Population Sciences;Postbaccalaureate;Postdoctoral Fellow;pre-clinical;pre-doctoral;Process;programs;recruit;Recruitment Activity;Relationship-Building;Research;research faculty;Research Personnel;Research Project Grants;Research Training;Resource Development;Resources;School-Age Population;Schools;Scientist;senior faculty;skills;Students;success;synergism;Teacher Professional Development;tool;Training;Training Activity;Training and Education;Training Programs;Translational Research;Travel;Underrepresented Minority;Underrepresented Students;Underserved Population;United States National Institutes of Health;Universities;Vision;Woman;Yale Cancer Center

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Cancer;Immunotherapy

PHR: CANCER IMMUNOLOGY RESEARCH PROGRAM – NARRATIVE Not applicable.

PI_NAMEs: BOSENBERG, MARCUS W (contact)

PROJECT_TERMS: Animal Model;anti-cancer;anti-tumor immune response;arm;Award;Biological Markers;Cancer Biology;Cancer Center Support Grant;cancer immunotherapy;Cancer Patient;cancer therapy;care outcomes;Cell Therapy;Clinic;Clinical;Clinical Trials;Code;Collaborations;Communication;Dedications;Development;Developmental Therapeutics Program;Discipline;Doctor of Philosophy;empowerment;Equity;Evaluation;experience;Faculty;Funding;Future;Goals;Immune;Immune checkpoint inhibitor;immune resistance;Immune response;Immune Targeting;Immunobiology;Immunologist;Immunology;Immunooncology;Immunotherapy;improved;Infection;Inflammation;Infrastructure;Innate Immune System;insight;International;Journals;Lead;Leadership;Link;Malignant Neoplasms;Medical;member;Mission;Modeling;mortality;next generation;novel strategies;novel therapeutic intervention;novel therapeutics;Paper;Patient-Focused Outcomes;Patients;Play;Process;programs;Publications;Publishing;Regulation;Research;research clinical testing;Research Personnel;Resource Sharing;Resources;Role;Scientist;Strategic Planning;Testing;Training;Translating;translational approach;Translations;tumor;tumor immunology;Underrepresented Populations;United States National Academy of Sciences;Work

PROJECT_TITLE: Cancer Immunology Research Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Obesity;Prevention;Rare Diseases;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PHR: CANCER PREVENTION AND CONTROL RESEARCH PROGRAM – NARRATIVE Not applicable.

PI_NAMEs: MA, XIAOMEI  (contact)

PROJECT_TERMS: Address;Affect;Alcohol consumption;anti-cancer research;Appointment;Area;Award;Basic Science;Behavior Therapy;Behavioral;Breast;Cancer Burden;Cancer Center Support Grant;Cancer Control;Cancer Control Research;Cancer Control Research Program;Cancer Etiology;cancer health disparity;cancer prevention;Cancer Prevention Intervention;cancer risk;cancer site;Cancer Survivor;Cancer Survivorship;cancer type;career;Caring;case control;Catchment Area;Child;Clinical;clinical epidemiology;clinical practice;Clinical Research;Code;Collaborations;Collection;Colon;Communities;community center;community engagement;comparative effectiveness;Connecticut;Data;Death Rate;design;Development;Diet;Direct Costs;Disease;Doctor of Philosophy;early onset;Endometrial Carcinoma;environmental chemical exposure;Environmental Risk Factor;Epigenetic Process;Equity;Exercise;experience;Funding;Genetic Predisposition to Disease;genetic risk factor;Goals;Grant;Head and Neck Cancer;Health Disparities Research;health equity;Health Services Research;Hematologic Neoplasms;Human Papilloma Virus Vaccination;improved;Incidence;Intervention;Journals;K-Series Research Career Programs;large datasets;Leadership;Life Style;Lung;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant neoplasm of thyroid;Malignant Neoplasms;Melanoma;member;men;Mentors;Mission;NCI Center for Cancer Research;novel;Obesity;obesity prevention;Observational Study;Oncology;Outcome;Outcomes Research;Paper;Patient-Focused Outcomes;Patients;Peer Review;Physical activity;Play;Policies;Population;Prevention;Primary carcinoma of the liver cells;programs;Prospective, cohort study;Prostate;Publishing;Quality of Care;Quality of life;randomized trial;Randomized, Controlled Trials;recruit;Recurrence;Research;Research Methodology;Research Support;Risk Factors;Risk Marker;Role;Schools;screening;Screening for cancer;Skin Cancer;Smoking;smoking cessation;social health determinants;Strategic Planning;structural determinants;Surveys;Symptoms;tobacco control;Training;Training and Education;Training Programs;Translating;Translational Research;Translations;Underrepresented Populations;Underserved Population;Voice;Woman;Work;Yale Cancer Center

PROJECT_TITLE: Cancer Prevention & Control Research Program


NIH_SPENDING_CATS: Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Precision Medicine

PHR: DEVELOPMENTAL THERAPEUTICS RESEARCH PROGRAM – NARRATIVE Not applicable.

PI_NAMEs: BURTNESS, BARBARA  (contact)

PROJECT_TERMS: Address;Antibodies;Applications Grants;Applied Research;Area;Arts;Award;Basic Science;Biology;Cancer Center Support Grant;cancer immunotherapy;cancer therapy;Chemicals;Chemistry;Clinical;clinical candidate;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Code;Combination Drug Therapy;Communities;community engagement;Conduct Clinical Trials;Cytotoxic Chemotherapy;Decentralization;design;Development;Developmental Therapeutics Program;Direct Costs;DNA Repair;drug candidate;drug discovery;Drug resistance;early phase clinical trial;early phase trial;Early Therapeutic-Clinical Trials Network;Engineering;Enrollment;Evaluation;Faculty;Fostering;Funding;Future;Goals;Grant;Growth;Head and Neck Cancer;Head and neck structure;Hybrids;Immune;Immunologics;Immunotherapy;improved;Incubators;Industry;innovation;Institution;interdisciplinary collaboration;International;Investigational Therapies;Investments;Journals;Laboratories;Lead;Leadership;Lung;Malignant neoplasm of lung;Malignant Neoplasms;medical schools;Medicine;meetings;Melanoma;member;Mentors;Mentorship;methylation biomarker;Mission;Modeling;Molecular;Molecular Profiling;Mutation;National Clinical Trials Network;NCI Center for Cancer Research;new therapeutic target;novel;novel anticancer drug;novel marker;novel therapeutics;Paper;patient population;Patient Selection;Patients;Peer Review;personalized medicine;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;phase I trial;pre-clinical;preclinical study;predictive marker;Process;programs;Public Health;Publications;Publishing;rational design;recruit;refractory cancer;Research;Research Personnel;Resistance;Resource Sharing;Resources;Role;Science;Site;Skin;structural biology;Structure;targeted treatment;Techniques;Therapeutic;Therapeutic Research;Tissue Banks;TP53 gene;Training;Translating;Translational Research;translational therapeutics;trial design;tumor;underserved community;Underserved Population;Work;Yale Cancer Center

PROJECT_TITLE: Developmental Therapeutics Research Program