NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Data Science;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PHR: Project Narrative - This application aims to identify determinants, molecular networks and key processes behind heterogeneous responses in the population to influenza infection and vaccination using integrative multi-scale network biology approaches. Key findings will be validated in silico, in vitro, and in vivo.

PI_NAMEs: FORST, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Algorithms;Anti-viral Agents;Antibodies;Antibody-mediated protection;Applied Research;Automobile Driving;Basic Science;Behavior;bioinformatics resource;Biological;Biology;Cells;Cellular Immunity;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Characteristics;Child;cohort;Communicable Diseases;Communities;Complex;cross reactivity;cross-species transmission;Data;data access;data resource;Data Set;Databases;Demographic Factors;Dimensions;Disease;Effectiveness;Emerging infection;Epitopes;Essential Genes;experimental study;fighting;Gene Expression;Generations;genetic signature;Genomics;Goals;high risk;high risk population;Human;Immune;Immune response;Immune system;Immunity;Immunologics;improved;in silico;In Vitro;in vivo;Individual;Infection;Influenza;Influenza A virus;Influenza B Virus;influenza epidemic;influenza infection;Influenza vaccination;influenza virus strain;influenza virus vaccine;innovation;Integration Host Factors;Investments;Lead;Life;Linear Models;Machine Learning;Mediating;Modeling;Molecular;molecular scale;Morbidity - disease rate;mortality;Multiomic Data;multiple omics;Mus;National Institute of Allergy and Infectious Disease;Native-Born;Network-based;novel;obese person;Pathogenesis;Pathology;Pathway Analysis;Pathway interactions;Physiological;Polysaccharides;Population;predictive modeling;Pregnant Women;Prevention;Process;programs;Property;protein expression;Proteins;Proteomics;Recovery;Research;Resources;response;Risk;Risk Factors;scaffold;seasonal influenza;Seasons;Serology;Severities;Severity of illness;Software Tools;System;Systems Biology;Testing;Therapeutic;Tissues;trait;Transcript;transcriptome sequencing;transcriptomics;Vaccination;Viral;Virus;Whole Organism

PROJECT_TITLE: Deciphering the Heterogeneous Response to Influenza by a Multi-Scale Systems Approach


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Per PAR-21-321 instructions, this component is not required.

PI_NAMEs: PATANKAR, MANISH S (contact)

PROJECT_TERMS: Advisory Committees;animal imaging;Antibodies;assay development;Award;Basic Science;Biological;Biological Assay;Biometry;Biotechnology;Businesses;Calibration;Cancer Center;Cancer Center Support Grant;Canis familiaris;Cell Separation;Cells;cellular imaging;Clinical;Clinical Research;Collaborations;Color;Communities;complex data;Comprehensive Cancer Center;Computer software;computerized tools;Computers;Consultations;cost;Cytometry;Data;data acquisition;Data Analyses;Data Set;Dedications;design;Development;DNA;Education;Educational workshop;equipment acquisition;experience;experimental study;Faculty;Family suidae;Flow Cytometry;Flow Cytometry Shared Resource;Fluorescence;Funding;Goals;Grant;Human;Image;Immunology;Immunotherapy;informatics shared resource;Infrastructure;Institution;Instruction;instrument;instrumentation;Intervention;Journals;Label;Laboratories;laboratory facility;Lasers;Leadership;lectures;Location;Malignant Childhood Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Manufacturer;Marketing;Measures;Medical Research;member;Methods;Mission;Modernization;new technology;operation;pediatric department;Pediatric Neoplasm;peer;Peer Review;Play;Population;precision medicine;Productivity;programs;protocol development;Protocols documentation;Publications;Publishing;Radiation therapy;radioactivity analysis;Radionuclide therapy;Reagent;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;RNA;Rodent;Role;Sampling;satisfaction;Services;single cell analysis;single cell genomics;single cell sequencing;Sorting;Strategic Planning;Surveys;Technical Expertise;theranostics;Training;Training and Education;Translational Research;United States National Institutes of Health;Universities;Wisconsin

PROJECT_TITLE: Flow Cytometry Laboratory

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Understanding the neural bases of affiliative caregiving is crucial to developing improved treatments and interventions for reducing the negative impacts of poor parenting or other conditions associated with deficits in empathy. Despite the importance of both affiliative prosocial behaviors and parental caregiving for developing and maintaining social bonds, their underlying neural circuitry remains incompletely characterized. The proposed research will explore the shared neural mechanisms of these behaviors, providing insight into the fundamental principles subserving social affiliation.

PI_NAMEs: LIM, KAYLA Y (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Adult;Affect;affiliative behavior;Area;base;Behavior;Behavioral;Behavioral Mechanisms;Borderline Personality Disorder;caregiving;Caring;Cells;Chemicals;Child Rearing;Cues;Data;Development;Disease;Distress;Emotional;Empathy;experience;experimental study;Fiber;Grooming;Helping Behavior;Hypothalamic structure;Impairment;improved;in vivo imaging;Individual;insight;Intervention;Maintenance;Mammals;mature animal;Medial;Mediating;Mental Health;Mus;Narcissistic Personality Disorder;neural;neural circuit;neurodevelopment;neuromechanism;Neurons;neuropsychiatry;offspring;Optics;optogenetics;parental role;Pathway interactions;Personal Satisfaction;Photometry;physical conditioning;point of care;Population;Postpartum Depression;Preoptic Areas;Process;psychologic;pup;Quality of life;Regulation;Research;response;Retrieval;Rodent;Role;Sensory;Sex Behavior;Shapes;social;social attachment;Social Processes;Stress;stress management;Symptoms;System;Testing;Touch sensation;Ventral Tegmental Area;Viral;welfare

PROJECT_TITLE: Shared neural circuits of prosocial and parenting behaviors in the hypothalamus


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: BOSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Narrative Our previous work has shown that mesenchymal stem cells-derived extracellular vesicles (MSC-EVs) enhance recovery of motor function following cortical injury in aged rhesus monkeys, proving to be a promising therapeutic for stroke, head injury or Alzheimer’s Disease Related Dementias in humans. Systemic MSC-EV treatment was associated with a reduction of chronic injury-induced microglial neuroinflammation, neuronal excitotoxicity, synapse loss, oligodendrocyte damage and myelination deficits, but the temporal dynamics and underlying mechanisms of MSC-EV mediated enhancement of recovery remain unknown. This proposal aims to conduct multimodal behavioral, proteomic, molecular, and physiological in vivo investigation in monkeys combined with elucidating the effective content of MSC-EV using human-derived in vitro model, to unravel the mechanism(s) of action and effects of MSC-EVs on acute or chronic stages of recovery after injury, and fine tune its efficacious as a therapeutic for age-related injury and neurodegenerative diseases.

PI_NAMEs: MEDALLA, MARIA ;MOORE, TARA L (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Acceleration;Acute;age related;aged;aging brain;Alzheimer's disease related dementia;anatomical tracer;Anti-Inflammatory Agents;Area;Astrocytes;Attention;Automobile Driving;Axon;Behavioral;behavioral outcome;Biological Markers;Blood;Brain;brain cell;brain tissue;cell injury;Cell Survival;cell type;Cells;Chronic;Cognitive deficits;cohort;Craniocerebral Trauma;deprivation;Development;Dimensions;Early treatment;Encapsulated;Environment;excitotoxicity;Exhibits;extracellular vesicles;FDA approved;Female;FOS gene;Glucose;Hand;hand dysfunction;Harvest;Histologic;Hour;Human;Immediate-Early Genes;Immune signaling;In Vitro;in vitro Model;in vivo;Inflammation;Inflammatory;inflammatory marker;Injury;injury recovery;Intravenous;Investigation;Knowledge acquisition;Label;Lesion;Macaca mulatta;Magnetic Resonance Imaging;male;Maps;Measures;Mediating;Mesenchymal Stem Cells;mesenchymal stromal cell;Microglia;MicroRNAs;Microscopy;Molecular;Molecular Mechanisms of Action;Monkeys;Motor;Motor Cortex;motor deficit;motor function recovery;multidisciplinary;multimodality;Myelin;myelination;Nature;Nerve Degeneration;neural;neural circuit;Neurites;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuronal excitability;Neuronal Plasticity;Neurons;neuroprotection;Oligodendroglia;oxidative damage;Oxidative Stress;Oxygen;patch clamp;Phenotype;Physiological;Physiology;Postoperative Period;Process;Proteins;Proteomics;Recovery;Recovery of Function;Recovery Support;remyelination;repaired;Resolution;response;response to injury;sex;Signaling Protein;single nucleus RNA-sequencing;single-cell RNA sequencing;Stroke;Synapses;Testing;Therapeutic;Time;Tissue Harvesting;tissue repair;Tracer;Training;transcriptomics;Validation;Work

PROJECT_TITLE: Mechanisms underlying extracellular vesicle mediated changes in inflammation, neural circuitry and plasticity following cortical injury in aged monkeys

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Biotechnology;Cancer;Prostate Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

ORG_CITY: CORAL GABLES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Castration-resistant prostate cancer (CRPC), a leading cause of cancer-related deaths in American men, emerges following failure of standard-of-care androgen deprivation therapy and leads to fatal disease. Using transcriptome-wide screening of a novel CRPC emergence model developed in our laboratory, we have identified soluble guanylyl cyclase (sGC) as a novel, clinically actionable target in CRPC. Our research will investigate stimulation of sGC activity via riociguat, a repurposed FDA-approved and well-tolerated drug, as a potentially safe and effective approach to reduce CRPC growth and progression.

PI_NAMEs: RAI, PRIYAMVADA  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Affect;Agonist;American;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;Antitumor Response;Automobile Driving;Biological Assay;Biology;bone;Cancer Etiology;cancer stem cell;Cardiopulmonary;Castration;CD44 gene;Cells;Cessation of life;Clinic;clinical translation;clinically actionable;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;combat;combinatorial;Complex;Cyclic GMP;Data;Data Set;deprivation;Development;Disease;DNA Repair;Down-Regulation;Failure;FDA approved;Functional Regeneration;Genetic;Genetic Transcription;Growth;Heme;Hormones;hypertension treatment;Hypoxia;improved;in vivo;Invaded;Kinetics;Laboratories;Maintenance;Mediating;men;Metabolic;Metastatic Neoplasm to the Bone;Mitochondria;Modeling;Molecular;Natural regeneration;novel;Oncogenic;Outcome;overexpression;Oxidation-Reduction;Oxidative Stress;Pathway interactions;patient derived xenograft model;patient stratification;Patients;Pharmaceutical Preparations;pharmacologic;Physiological;PIK3CG gene;potential biomarker;pre-clinical;prevent;progression marker;prostate cancer metastasis;prostate cancer model;Proteins;PSA level;Pulmonary Hypertension;Radiation;radiation resistance;Reactive Oxygen Species;Reagent;Refractory;Regulation;Research;Resistance;Respiration;response;screening;Signal Pathway;Signal Transduction;small hairpin RNA;Soluble Guanylate Cyclase;Specimen;standard of care;stem cell biomarkers;stem cell population;stem cells;Stress;Testing;Therapeutic;transcriptome;transcriptomics;Translations;Treatment Efficacy;tumor;tumor growth;tumor hypoxia;Tumor Oxygenation;Vasodilator Agents;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Novel Mechanisms of ROS/RNS Signaling Underlying Castration-Resistant Prostate Cancer Emergence and Progression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Q(02)M]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PI_NAMEs: BRADFIELD, CHRISTOPHER A (contact)

PROJECT_TERMS: Adopted;Advanced Malignant Neoplasm;analytical tool;Animal Experimentation;Animal Husbandry;Animal Model;Animals;anti-cancer research;Cancer Center;Cancer Center Support Grant;Cancer Etiology;Cancer Model;cancer prevention;cancer therapy;cancer type;Cell Line;Cell model;Cells;Characteristics;Clonality;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Comprehensive Cancer Center;cost;cost effective;Country;COVID-19 pandemic;CRISPR screen;Cryopreservation;Data;Databases;Dedications;Deposition;Derivation procedure;design;Detection;Development;Electroporation;Embryo;embryo cryopreservation;Embryo Transfer;Emergency Situation;Equipment;Equipment and supply inventories;established cell line;Ethics;Excision;Exhibits;experience;experimental study;Family suidae;Fertilization in Vitro;Flow Cytometry;Freezing;Funding;Generations;Genetic;Genetic Engineering;Genome;genome editing;genome-wide;Genome-wide Unbiased Identification of DSBs Enabled by sequencing;homologous recombination;Human;human model;Image;improved;Infrastructure;innovation;insertion/deletion mutation;Institution;Instruction;International;Laboratories;Malignant Neoplasms;member;Methods;Microinjections;Mission;Modeling;Modernization;Monitor;Mouse Strains;Mus;Neoplasm Metastasis;novel;pathogen;Patients;personalized medicine;Pharmacotherapy;Phenotype;preservation;pressure;prevent;Procedures;programs;Rat Strains;Rattus;Recovery;reproductive;Reproductive Biology;Research;Research Personnel;Resource Sharing;Resources;Respondent;Rodent;Rodent Model;Sampling;screening services;Services;somatic cell gene editing;sperm cryopreservation;Surveys;System;Technology;Training;Transgenes;Transgenic Animals;Transgenic Model;tumor progression;United States;Universities;University resources;Vendor;Wisconsin;Work

PROJECT_TITLE: Genome Editing and Animal Models


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Hypertension;Kidney Disease;Patient Safety;Prevention

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

PHR: PROJECT NARRATIVE Hypertension treatment affects nearly all adults with chronic kidney disease, and key evidence gaps contribute to suboptimal management in this high-risk population. This study will extend evidence from large clinical trials in hypertension to evaluate the comparative risks and benefits of intensive versus standard blood pressure targets in real world adults with chronic kidney disease.

PI_NAMEs: KURELLA TAMURA, MANJULA  (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Adult;Affect;African American;Attenuated;Benefits and Risks;Blood Pressure;blood pressure intervention;blood pressure medication;California;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chronic Kidney Failure;Clinical;clinical decision support;Clinical Trials;cohort;comparative;Consensus;Data;Databases;Decision Making;Diabetes Mellitus;Disease Management;Disease Progression;Electronic Health Record;Eligibility Determination;Event;Goals;Guidelines;Healthcare Systems;high risk population;Hypertension;hypertension control;hypertension treatment;Individual;innovation;Intervention Trial;Kidney;Kidney Diseases;Laboratories;Modeling;mortality;mortality risk;novel;older adult;Participant;patient population;Patients;personalized predictions;Persons;Pharmaceutical Preparations;Pharmacy facility;Population;profiles in patients;randomized trial;Recommendation;Renal function;Research Priority;Risk;Secondary Prevention;Serious Adverse Event;Stroke;Subgroup;symposium;Target Populations;treatment effect;Uncertainty;Veterans Health Administration

PROJECT_TITLE: Applying Hypertension Clinical Trials to Real World Adults with CKD

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE AZD9291 is an FDA-approved 3rd generation EGFR inhibitor drug for the treatment of patients with EGFR mutant lung cancer that has become resistant to 1st generation EGFR inhibitors through the T790M mutation and for EGFR mutation-positive advanced lung cancer as a front line treatment. We are committed to developing science-driven effective therapeutic strategies for overcoming acquired resistance to AZD9291 and other 3rd generation EGFR inhibitors, a key clinical obstacle in the targeted therapy of EGFR mutant lung cancer through fully understanding the underlying mechanisms. This proposal will address these challenging issues primarily through demonstrating the previously unknown role of c-Myc modulation in EGFR-targeted cancer therapy.

PI_NAMEs: SUN, SHI-YONG  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Animal Model;Apoptotic;Area;Biochemical;Biological;Biological Assay;Bromodomains and extra-terminal domain inhibitor;c-myc Genes;cancer cell;Cancer cell line;Cancer Patient;cell growth;Cell Line;Cell Proliferation;Cell Survival;chemotherapy;Chromosomal translocation;Clinic;Clinical;clinical translation;Clinical Treatment;combinatorial;Data;Development;Disease Progression;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Erlotinib;Event;Exons;Family member;FDA approved;Future;Gefitinib;Gene Amplification;gene cloning;Generations;Genes;Glutamine;Goals;Human;Human Genome;Immunity;In Vitro;in vivo;Induction of Apoptosis;knock-down;Knock-out;Knowledge;Link;lung cancer cell;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metabolism;Methods;Modeling;Molecular;mutant;Mutation;Non-Small-Cell Lung Carcinoma;Outcome Study;overexpression;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Physiological Processes;Play;Point Mutation;pre-clinical;Proliferating;Proteasome Inhibition;Proteins;Radiation therapy;Regimen;Regulation;Relapse;research clinical testing;Resistance;resistance mechanism;response;Role;Safety;Science;small molecule inhibitor;targeted cancer therapy;targeted treatment;Testing;therapeutic target;therapeutically effective;Tissues;transcription factor;Translating;treatment comparison;Treatment Efficacy;tumor

PROJECT_TITLE: c-Myc modulation and its implications in EGFR-targeted cancer therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-L(02)M]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The Administrative Core will assure the effectiveness of the Diabetes Reseath Center (DRC) at the University of Alabama in meeting the center’s stated goals and specific aims, and will be directed by W. Timothy Garvey MD, assisted by associate directors Drs. Barbara Gower, Anath Shalev, and Andrea Cherrington. The Core will oversee the Pilot & Feasibility Grant Program, the Enrichment & Training Program, and the biomedical research core facilities. The ultimate goal of the Core is to assure the growing vitality of an intellectual community and a highly productive research program in diabetes for the benefit of our DRC members, trainees, patients, and community.

PI_NAMEs: GARVEY, W TIMOTHY (contact)

PROJECT_TERMS: Alabama;Animals;Area;base;Basic Science;Biomedical Research;Cardiometabolic Disease;career development;Cellular biology;circadian biology;Collaborations;Communication;Communities;Consensus;Core Facility;Decision Making;Development;Diabetes Mellitus;Disease;dissemination strategy;Doctor of Philosophy;Education;educational atmosphere;Effectiveness;Evaluation;Evolution;Faculty;Fostering;Goals;Grant;Growth;Human;Individual;Information Dissemination;innovation;Interdisciplinary Study;Intervention;Investigation;Islet Cell;Leadership;Life;meetings;member;Mentors;Mission;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;operation;Patients;Physiology;Postdoctoral Fellow;Prevention;Productivity;programs;Progress Reports;Publications;Quality Control;Recommendation;recruit;Reporting;Research;research and development;Research Personnel;Research Project Grants;Research Training;Resources;Review Committee;Services;Sleep;social;Students;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: UBOHA, NATALIYA   (contact)

PROJECT_TERMS: Accountability;Administrator;Amendment;anti-cancer research;Authorization documentation;Award;base;Cancer Center;Cancer Center Support Grant;Cancer Patient;cancer prevention;Clinic;Clinical;clinical application;clinical material;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Network;Competence;Comprehensive Cancer Center;Conceptions;Counseling;data quality;design;Documentation;Drug Compounding;Drug Interactions;Electronics;Enrollment;Ensure;Environment;Evaluation;expiration;Funding;gene therapy;Gene Therapy Agent;Geography;Good Clinical Practice;Head and neck structure;Health Personnel;Health system;Healthcare;improved;improved outcome;Institution;Instruction;Investigational Drugs;Investigational Therapies;Knowledge;Leadership;Location;Malignant Neoplasms;Medical center;member;Mission;Monitor;Monograph;National Clinical Trials Network;NCI Center for Cancer Research;Neck Cancer;novel therapeutics;Oncology;participant enrollment;participant safety;Patient Participation;Patients;Peer Review;Pharmaceutical Preparations;Pharmaceutical Services;Pharmacologic Substance;Pharmacy facility;Positioning Attribute;Preparation;Procedures;Process;programs;Protocols documentation;quality assurance;Randomized;Regulation;Research;research faculty;Research Infrastructure;Research Personnel;research study;Research Subjects;Resolution;Resources;Respondent;response;Risk;satisfaction;Security;Services;Site;Source;supply chain;Surveys;System;Testing;Training;Translating;treatment research;United States National Institutes of Health;Universities;Wisconsin;Work

PROJECT_TITLE: Pharmaceutical Research Center


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Nutrition;Obesity;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: Chicago

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Reward seeking and its underlying neurocircuitry contribute to the development of both obesity and drug addiction – disorders that are profound threats to public health. Physiological need states (e.g. thirst, hunger) are risk factors for abnormal reward seeking and drug relapse. Proposed studies will elucidate mechanisms by which physiological state influences reward circuits to identify the most promising therapeutic targets.

PI_NAMEs: ROITMAN, MITCHELL F (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: addiction;Address;Animals;approach behavior;Attention;Behavior;Behavioral;Biological Assay;blood-brain barrier permeabilization;Body Fluids;Caloric Restriction;Cell Nucleus;Cells;Central Nervous System;Communication;comorbidity;Consummatory Behavior;Consumption;cost;Cues;Dehydration;Development;Disease;Dopamine;dopaminergic neuron;Drug abuse;Drug Addiction;drug relapse;drug reward;drug withdrawal;Eating;Elements;Equilibrium;feeding;Feeding behaviors;Fiber;Fluid Balance;Food;food consumption;Glutamates;Goals;Homeostasis;hormonal signals;Hormones;Hunger;Hyperphagia;hypocretin;Hypothalamic structure;in vivo;Induced Neurons;Ingestion;Knowledge;Lateral Hypothalamic Area;Lateral Hypothalamic Nucleus;Learning;Light;Liquid substance;Measures;mesolimbic system;Morphine;Morphine Dependence;motivated behavior;Motivation;negative affect;Negative Reinforcements;neural circuit;Neurons;new therapeutic target;Nucleus Accumbens;Nutrient;Obesity;Obesity Epidemic;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid withdrawal;Output;parent grant;Peptides;Peripheral;Persons;Pharmaceutical Preparations;Phase;Photometry;Physiological;Play;Population;Process;programs;Psychological reinforcement;psychostimulant;Public Health;Rattus;receptor;recruit;Relapse;Research;response;Rewards;Risk Factors;Role;Satiation;Self Administration;Self Stimulation;Services;Shapes;Signal Transduction;Site;Stimulus;Structure of nucleus infundibularis hypothalami;Subfornical Organ;therapeutic target;Thirst;Translating;Ventral Tegmental Area;Water;Water consumption;Withdrawal

PROJECT_TITLE: Modulation of Nac-DA Signaling by Learning, Motivational State and Peptides

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Violence Research

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE The development of strategies and interventions for preventing or minimizing violent behavior in individuals with psychotic disorders has been limited, in part, by a lack of information about the effects of antipsychotic medications, and in particular clozapine, on violent acts in community settings. In this project, we will determine whether clozapine, when administered in real-world settings, decreases the risk for violent acts in individuals with schizophrenia at high risk for violence when compared to treatment with other antipsychotic medications, and investigate whether previously identified change mechanisms are operative in the effectiveness setting. Examining clozapine in this way will foster a better understanding of the effects of clozapine on violent acts in community settings and allow us to test a scalable intervention and service delivery approaches that can be broadly implemented using typically available resources, and as such has significant public health implications.

PI_NAMEs: KELLY, DEANNA L (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Address;Aggressive behavior;Alcohol consumption;Alcohols;Antipsychotic Agents;antisocial behavior;Behavior;blind;Clinical;Clinical Research;clinical research site;Clinical Trials;clinically relevant;Clozapine;Collaborations;community partners;community setting;community violence;Data;Delusions;Development;Diagnostic;Disparate;Effectiveness;effectiveness outcome;effectiveness study;efficacy trial;Ensure;Fostering;Future;high risk;Hostility;Human Resources;improved;Impulsivity;Individual;individual patient;interest;Intervention;intervention delivery;Interview;Link;Magnetic Resonance Imaging;Measures;Multi-Institutional Clinical Trial;Murder;Neurobiology;New York;open label;Outcome;Outcome Measure;Outpatients;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Populations at Risk;Positron-Emission Tomography;prevent;primary outcome;Property;Protocols documentation;psychopathic personality;Psychoses;psychotic;Psychotic Disorders;Public Health;Randomized;randomized, clinical trials;Reporting;Research;Research Domain Criteria;Resources;Risk;Risk Reduction;Running;Safety;Sample Size;Schizophrenia;Sedation procedure;Self-Injurious Behavior;service delivery;Site;social stigma;substance use;Symptoms;Syndrome;Testing;Time;treatment as usual;treatment effect;Violence;violence prevention;Vulnerable Populations;Work

PROJECT_TITLE: 4/7 Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial


PI_NAMEs: WEICHERT, JAMEY P (contact)

PROJECT_TERMS: Address;advanced analytics;Alpha Particles;analog;Animal Housing;animal imaging;Animal Model;animal tissue;Animals;Award;Biodistribution;Biological Assay;Bioluminescence;Blood;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Detection;cancer imaging;Cancer Model;Cancer Patient;cancer therapy;Cells;chelation;Chemistry;clinical imaging;clinical translation;Clinical Trials;Complete Blood Count;Comprehensive Cancer Center;Consultations;cost;Data;data acquisition;Dedications;Development;Developmental Therapeutics Program;digital;Discipline of Nuclear Medicine;Ensure;Equipment;Evaluation;ex vivo imaging;Experimental Designs;Fluorescence;Funding;Gamma counter;Generations;Grant;Head and neck structure;Hematology;Image;imaging agent;imaging capabilities;imaging modality;imaging study;Imaging Techniques;Imaging technology;Immune;Immune system;Immunologic Stimulation;improved;in vivo;Individual;Infrastructure;innovation;Instruction;instrumentation;Investigational Drugs;Isotopes;Leadership;Magnetic Resonance Imaging;Malignant Neoplasms;member;Metals;Mission;Modality;Modeling;molecular imaging;Morphologic artifacts;Motion;Mus;Near-infrared optical imaging;new technology;Optics;Pathway interactions;personalized medicine;PET/CT scan;Pharmacology;Pharmacology and Toxicology;pre-clinical;preclinical development;preclinical evaluation;preclinical imaging;Preparation;Process;programs;Proteomics;Protocols documentation;Publications;Quality of life;Radiation;Radiation therapy;Radioactive;Radioactivity;Radionuclide therapy;Rattus;reconstruction;Research;Research Personnel;Resolution;Rodent;Roentgen Rays;Role;Running;Safety;Science;Services;Signal Transduction;single photon emission computed tomography;small molecule;Staging;Strategic Planning;success;survival outcome;System;T memory cell;Technetium Tc 99m Medronate;Technology;theranostics;Therapy trial;Time;Tissue imaging;Tissues;Toxicology;Training;Translating;translational medicine;Translational Research;treatment planning;treatment response;tumor;tumor microenvironment;ultrasound;United States National Institutes of Health;Universities;whole animal imaging;Wisconsin;Work

PROJECT_TITLE: Small Animal Imaging and Radiotherapy Facility


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Over the next 5 years, we will create translational research teams who envision the impact of their work on the communities that they seek to benefit (patients, providers, policymakers, etc.) at each step of the research process, from conceptualizing questions through implementing findings. Every CTSI-supported study will be “designed for impact” (i.e., articulate paths for dissemination to and implementation by stakeholders).

PI_NAMEs: REIS, STEVEN E (contact)

PROGRAM_OFFICER_NAME: HARTSHORN, CHRISTOPHER

PROJECT_TERMS: Acceleration;Address;advanced analytics;Age;Articulation;Belief;Caring;catalyst;Clinical;Clinical Research;Clinical Sciences;Clinical Trials Network;cohort;Collaborations;Communities;community engagement;Community Networks;community organizations;community partners;comparative effectiveness;Competence;cultural values;design;Devices;Discipline;Dissemination and Implementation;Ecosystem;effectiveness clinical trial;Environment;experience;Foundations;health practice;Healthcare Systems;Heterogeneity;Individual;Informatics;informatics tool;Infrastructure;Institution;Lead;member;Methods;Mission;Multi-Institutional Clinical Trial;Newborn Infant;novel diagnostics;older adult;operation;Participant;Patients;peer;Pennsylvania;Policy Maker;Population;Pragmatic clinical trial;precision medicine clinical trials;Preventive;Process;programs;Provider;Public Health;Registries;Research;Research Design;Research Methodology;Research Personnel;research study;Research Training;Resources;Scientist;Services;Societies;Therapeutic;tool;Training;Translational Research;Translations;Trust;Universities;Vision;Voice;Work;Workforce Development;workforce needs

PROJECT_TITLE: University of Pittsburgh Clinical and Translational Science Institute


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: HIV/AIDS;Mental Health;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Columbia University Mailman School of Public Health requests funding for a pre-doctoral research training program to address SDH including structural racism and gender inequality, intersectional stigma, residential segregation, aging, and marginalizing structures influencing HIV. All pre-doctoral students receive training in social determinants of health, HIV, and grantsmanship. This pre-doctoral program aims to prepare MSPH students for research and teaching careers that examine SHD, and marginalizing structural factors that influence HIV, nationally and globally.

PI_NAMEs: WINGOOD, GINA MARIA (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: HIV;social determinants

PROJECT_TITLE: Social Determinants of HIV


PHR: The Animal Physiology Core facilitates the study of animal models for investigators in the Diabetes Research Center at the University of Alabama at Birmingham. These studies of diabetes and cardiometabolic disease are conducted in ways that are relevant to human patients, and include regulation of glucose metabolism, how body weight is regulated and predisposes to diabetes, cardiovascular risk factors, effects of diets, and how genes cause diabetes. The humane use of animals is critical if we are to better understand mechanisms, develop new medications, and make research advances on behalf of our patients.

PI_NAMEs: HABEGGER, KIRK MICHAEL (contact)

PROJECT_TERMS: Access to Information;Alabama;Animal Model;Animals;Architecture;Area;B-Lymphocytes;base;Bioenergetics;Biology;blood glucose regulation;Body Composition;Body Temperature;Body Weight;Cardiometabolic Disease;cardiovascular risk factor;Cardiovascular system;Cell Physiology;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;cost effectiveness;cost efficient;Data;design;Diabetes Mellitus;Diet;Dual-Energy X-Ray Absorptiometry;Eating;energy balance;Energy Metabolism;Enzyme Kinetics;Equipment;Evaluation;Functional disorder;Funding;Generations;Genes;Genetically Modified Animals;Genotype;Glucose;Glucose Clamp;glucose metabolism;glucose tolerance;Glutathione Disulfide;Goals;Grant;Hormonal;Human;human disease;Hydrogen Peroxide;Hyperinsulinism;Image;improved;In Vitro;in vivo;in vivo evaluation;Indirect Calorimetry;instrumentation;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;islet;Isoprostanes;Knock-in;Knock-out;Lipid Peroxidation;Magnetic Resonance;Measures;metabolic rate;Metabolism;Methodology;Methods;microCT;Miniaturization;Mitochondria;mitochondrial metabolism;Modeling;monitoring device;morphometry;multidisciplinary;Nature;Output;Oxidation-Reduction;Oxidative Stress;Patients;Permeability;Pharmaceutical Preparations;Phenotype;Physiology;Preparation;Process;Production;Productivity;Publications;Reagent;Research;Research Personnel;Resolution;Resources;Rodent;Rodent Model;Services;Spirometry;Stress;Superoxide Dismutase;Technology;Tissues;tool;Training;Transgenic Animals;Transgenic Model;Transgenic Organisms;translational pipeline;Translational Research;Universities

PROJECT_TITLE: Animal Physiology Core


NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: MALECKI, KRISTEN MARY CHOSSEK (contact)

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;African American;anti-cancer research;Basic Science;Behavioral;biobank;Biological;Biological Markers;biomarker discovery;Black race;burden of illness;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research;cancer prevention;cancer risk;Cancer Science;cancer therapy;Catchment Area;Cause of Death;Censuses;Clinical;Clinical Sciences;Collaborations;Collection;Communities;community burden;community engagement;Community Networks;community organizations;Comprehensive Cancer Center;Consultations;cost effective;Coupled;Data;Data Collection;Data Set;data sharing networks;design;Development;disability;Disparity;disparity reduction;DNA;Economic Factors;Ensure;Environmental Pollution;Epidemiologist;Epidemiology;epidemiology study;Ethnic Origin;Ethnic Population;Etiology;experience;Faculty;Food Access;Fostering;Funding;geographic disparity;Goals;Health Sciences;Health Surveys;Healthcare;high risk;Housing;improved;Incidence;Individual;Infrastructure;innovation;Instruction;interdisciplinary approach;Investments;Knowledge;Link;Longitudinal cohort;Longitudinal cohort study;Malignant Neoplasms;Measurement;member;Methods;Mission;Monitor;multimodality;NCI Center for Cancer Research;Neighborhoods;novel;novel strategies;Nursing Faculty;Outcome;Physical Examination;Plasma;Population;population based;population health;Population Heterogeneity;Population Research;Population trends;Positioning Attribute;Prevalence;programs;Protocols documentation;Questionnaires;Race;racial population;Recording of previous events;recruit;Reporting;repository;Reproducibility;Research;research and development;Research Design;Research Infrastructure;Research Personnel;research study;Research Support;Resource Sharing;Resources;Risk Factors;Rural;Rural Community;rural dwellers;sample collection;Sampling;Science;Scientist;Serum;Services;Shapes;social;social factors;social health determinants;Social Sciences;Strategic Planning;Surveys;System;Translational Research;Translations;trend;Underrepresented Populations;United States;Universities;Urine;Validation;Vital Statistics;wearable device;Wisconsin

PROJECT_TITLE: Survey of the Health of Wisconsin


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Malaria;Orphan Drug;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease;Vector-Borne Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE This research will be conducted as part of a large clinical trial in Tanzania that provides hydroxyurea to prevent stroke in children with sickle cell anemia. The goal is to investigate the origins and clinical consequences of enlarged spleens among children in sub-Saharan Africa, both before and after hydroxyurea treatment. Many countries will soon widen access to hydroxyurea as an inexpensive treatment for sickle cell anemia, so determining its impact on splenic size and function will be crucial to prescribing hydroxyurea at safe and effective doses for young patients living in sub-Saharan Africa.

PI_NAMEs: SMART, LUKE  (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: 18 year old;3-Dimensional;5 year old;Address;Adult;Affect;Africa;Africa South of the Sahara;African;Age;Age Months;alpha thalassemia minor;alpha-Thalassemia;Anatomy;Atrophic;Attention;Biometry;blood rheology;career development;Cell Adhesion;Child;Clinical;clinical effect;clinical infrastructure;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;collaborative environment;Country;Data;Data Analyses;Development Plans;Diagnosis;Disease;Dose;Education;effective therapy;Enrollment;Environment;Erythrocytes;Etiology;Event;evidence base;experience;Fetal Hemoglobin;Frequencies;Functional disorder;functional status;Future;Goals;Guidelines;Hematological Disease;hydroxyurea;immune function;Immunology;improved;improved outcome;Incidence;Infection;Inflammation;Inherited;Knowledge;Laboratories;laboratory experience;Life;Malaria;malaria infection;Maximum Tolerated Dose;Measurement;Medical center;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Neonatal Screening;Ohio;Organ;Outcome;Palpable;Participant;Pathology;Patients;Pediatric Hospitals;Penicillins;peripheral blood;Persons;Physiology;Predisposition;preservation;Prevalence;Prevention program;programs;Prophylactic treatment;prospective;Publishing;Recommendation;Research;Research Personnel;Resource-limited setting;Resources;response;Risk;Risk Factors;Safety;screening program;Serology;Sickle Cell;Sickle Cell Anemia;Spleen;Splenomegaly;Statistical Methods;Stroke;Stroke prevention;Tanzania;Testing;Time;Toxic effect;Training;Transfusion;Translational Research;treatment comparison;treatment group;treatment trial;ultrasound;United States Food and Drug Administration;Vaccination;vaccine immunogenicity;Viral;Work

PROJECT_TITLE: Sickle Cell Anemia, Splenic Pathology, and Hydroxyurea in Sub-Saharan Africa

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Severe sepsis, defined as sepsis associated with acute organ dysfunction, is an increasing cause of morbidity and mortality among children and adults, and has been one of the most significant challenges in critical care. This study will determine the underlying mechanisms that lead to the accumulation of neutrophils in the organs that causes fatal hyper-inflammatory responses in septic patients. Understanding how to control tissue damage through manipulation of neutrophil resolution has potential applications in many acute/chronic inflammatory settings including sepsis.

PI_NAMEs: KIM, MINSOO  (contact);PIETROPAOLI, ANTHONY P

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Acute;Address;Adult;Age;Antibiotic Therapy;Apoptotic;arm;attenuation;Blood;C1q deficiency;Cessation of life;Child;Chronic;clinical care;comorbidity;Complement;Complement 1q;Complement Activation;conditional knockout;Critical Care;Critical Illness;diagnostic criteria;Disease;disease prognosis;druggable target;experimental study;Failure;Functional disorder;Gene Expression;Heterogeneity;high risk;Homeostasis;Human;Immune response;improved;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Investigational Therapies;Laboratories;Life;longitudinal analysis;Longitudinal Studies;Macrophage;Measures;Medical;microbiome;Modeling;Molecular Target;Morbidity - disease rate;mortality;mortality risk;Mus;mutant;neutralizing antibody;neutrophil;Neutrophil Infiltration;Organ;Organ failure;organ injury;participant enrollment;Pathology;Pathway interactions;patient population;patient response;patient subsets;Patient Triage;Patients;peripheral blood;Phagocytosis;preservation;Prevention;Prognosis;prognostic;Prognostic Marker;Proteins;Publishing;Recombinants;Recovery;Research Design;Resolution;response;risk stratification;Role;Sepsis;septic;septic patients;severe injury;Severity of illness;sex;Site;Subgroup;Supportive care;Survivors;Syndrome;systemic inflammatory response;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;Variant

PROJECT_TITLE: Complement C1q and sepsis associated fatalities

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: MATKOWSKYJ, KRISTINA A. (contact)

PROJECT_TERMS: Accreditation;American;Animal Experiments;Animal Model;animal tissue;Animals;anti-cancer research;Appropriateness Review;Authorization documentation;Award;Basic Cancer Research;biobank;Body Fluids;Cancer Center;Cancer Center Support Grant;Catchment Area;Cell Line;Clinical;Clinical Data;Clinical Trials;clinically relevant;Code;Collaborations;Collection;college;Comprehensive Cancer Center;Confidentiality of Patient Information;Consent;Consult;cost;Data;Data Analyses;Databases;Development;digital pathology;Direct Costs;Disease;Ensure;experimental study;Frozen Sections;Funding;Future;Genetic;Genomics;Grant;Health Surveys;Hematologic Neoplasms;Histopathology;Human;Human body;human model;human tissue;Image Analysis;Immunohistochemistry;Improve Access;improved;In Situ Hybridization;Infrastructure;innovation;Institution;Institutional Review Boards;Instruction;instrumentation;Laboratories;Link;machine learning algorithm;Malignant neoplasm of brain;Malignant Neoplasms;medical schools;member;Mission;Modality;Modeling;Molecular;Molecular Analysis;Molecular Medicine;molecular pathology;molecular phenotype;Molecular Profiling;Mus;NCI Center for Cancer Research;operation;Paraffin Embedding;Pathologist;Pathology;Patients;precision medicine;Procedures;Process;programs;Protocols documentation;quantitative imaging;repository;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resources;Sampling;Science;Services;Site;Slide;Specific qualifier value;Specimen;Strategic Planning;System;Tissue Embedding;Tissue Microarray;Tissue Stains;Tissues;translational cancer research;translational goal;Translational Research;tumor;Tumor Tissue;United States National Institutes of Health;Universities;Update;Wisconsin

PROJECT_TITLE: Translational Science Biocore


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE – OVERALL The prevention of cognitive decline, MCI and dementia is a major public health priority. The proposed Rush ADRC will build on three decades of a successful ADCC and generate resources to support a deeper understanding of the pathogenesis of MCI and dementia, and to identify novel therapeutic targets for its treatment and prevention.

PI_NAMEs: SCHNEIDER, JULIE A. (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Aging;Agreement;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Autopsy;Biological;Biological Markers;Biometry;Black Populations;Brain;Caregivers;Cell model;Clergy;Clinical;cohort;Cohort Studies;collaborative environment;Communities;community based research;computer infrastructure;computerized tools;Data;Data Collection;data harmonization;data management;Data Set;data sharing;Dementia;disease model;distributed data;Education;education research;Enrollment;ethnic minority;Ethnic Origin;Evaluation;Exercise;Faculty;follow-up;Funding;Goals;Grant;Heterogeneity;Human;human data;Impaired cognition;Incentives;Infrastructure;innovation;Institution;Latino;Latino Population;Leadership;Magnetic Resonance Imaging;Methodology;Molecular Profiling;multidisciplinary;Nature;neuroimaging;neuropathology;new therapeutic target;open data;Organ Donations;outreach;Participant;Pathogenesis;patient engagement;Patients;Persons;Pilot Projects;Positron-Emission Tomography;predictive modeling;Prevention;Procedures;Process;programs;public health priorities;public-private partnership;Publishing;racial diversity;racial minority;Recommendation;recruit;relational database;religious order study;repository;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Science;Source;Specimen;statistics;Strategic Planning;Structure;student mentoring;Systems Biology;Trust;virtual;Work

PROJECT_TITLE: Rush Alzheimer's Disease Research Center


PHR: The Human Physiology Core helps diabetes researchers by providing state-of-the-art, cost-effective, centralized services for assessment of hormones, glucose, and lipids from humans and animals. The core also provides measures of human body composition, energy metabolism, insulin sensitivity, insulin secretion, and physical activity for diabetes-related research studies. In addition, the Core promotes multi-disciplinary research in diabetes across the UAB campus, and offers training, advice, and instruction to students, fellows, and faculty.

PI_NAMEs: GOWER, BARBARA A (contact)

PROJECT_TERMS: Accelerometer;adipokines;Animals;Basic Science;Beta Cell;Biochemical;Biological;Biological Assay;Biopsy;Blood;blood glucose regulation;Body Composition;Body fat;Calorimetry;Cardiometabolic Disease;Cell Physiology;circadian;Clinical;Closure by clamp;Communities;Consultations;cost effective;Data;Development;Diabetes Mellitus;diabetes risk;doubly-labeled water;Dryness;Dual-Energy X-Ray Absorptiometry;Education;Energy Metabolism;Evolution;Exercise Test;Faculty;Fatty acid glycerol esters;Functional disorder;Glucose;glucose tolerance;Hormones;Hour;Human;Human body;Human Resources;human tissue;Indirect Calorimetry;inflammatory marker;Infrastructure;insight;Institution;Instruction;instrument;Insulin;insulin secretion;insulin sensitivity;Interdisciplinary Study;intravenous glucose tolerance test;Isotopes;Kidney;Lipids;Liquid substance;Magnetic Resonance Imaging;mathematical model;Measures;Metabolic;metabolic abnormality assessment;Metabolism;Methodology;Methods;Needles;new technology;Nitrogen;OGTT;Online Systems;Participant;Patients;Philosophy;Physical activity;Physiology;Pilot Projects;Play;Preparation;Protocols documentation;Quality Control;Research;Research Personnel;research study;response;Rest;Role;Sampling;Schedule;Services;Sinus;Sleep;Specimen;Spottings;Sterility;Students;Suction;Surgeon;System;Technology;Testing;theories;Time;tissue culture;tissue processing;Tissue Sample;Training;Translations;ultrasound;Universities;Work

PROJECT_TITLE: Human Physiology Core


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Clinical Research;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: NARRATIVE This proposal will answer two important questions about breast cancer. First, does a cancer patient’s muscle and fat mass affect the biologic characteristics of their tumor, and, second, does a tumor’s biology explain the relationship of muscle and fat mass to oncologic outcomes, specifically the risk of the cancer coming back or the patient dying of breast cancer. These answers could allow us to develop new treatments for cancer patients.

PI_NAMEs: FELICIANO, ELIZABETH MARJORIE CESPEDES (contact)

PROJECT_TERMS: Address;Adipose tissue;Affect;Animal Model;anti-tumor immune response;Archives;Back;Biologic Characteristic;Biological Markers;Biology;Body Composition;Body Size;Breast Cancer Patient;breast cancer progression;breast cancer survival;Breast Cancer therapy;cancer care;Cancer Patient;cancer recurrence;cancer risk;cancer subtypes;cancer therapy;Categories;CD8-Positive T-Lymphocytes;Cell Proliferation;Cessation of life;Characteristics;Chronic;Classification;Clinical;cohort;Computerized Medical Record;Data;data resource;Diagnosis;Disease;Drug or chemical Tissue Distribution;Ensure;epidemiology study;Epidermal Growth Factor Receptor;ERBB2 gene;Etiology;exhaust;exhaustion;experience;Fatty acid glycerol esters;follow-up;FRAP1 gene;Future;Gene Expression;Hormonal;Hormone Receptor;hormone receptor-positive;Human;Immune;immune function;Immunity;Impairment;improved;In Vitro;individualized medicine;Inflammation;interest;Intervention;Knowledge;Life Style;lifestyle intervention;Link;Longterm Follow-up;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Measures;Mediating;Mediation;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolic syndrome;Metabolism;Molecular;Molecular Epidemiology;molecular subtypes;mortality;mortality risk;multidisciplinary;Muscle;muscle form;nano-string;Obesity;Outcome;Pathway interactions;Patient risk;Patients;pharmacologic;Phenotype;PIK3CG gene;pre-clinical;Prognosis;Prognostic Factor;programmed cell death ligand 1;Proliferating;Proto-Oncogene Proteins c-akt;Recording of previous events;Recurrence;reduced muscle mass;Research;Risk;sample archive;Sample Size;Sampling;Signal Pathway;Signal Transduction;subcutaneous;T-Lymphocyte;Testing;Therapeutic Intervention;treatment and outcome;treatment response;tumor;Tumor Biology;Tumor Escape;Tumor Immunity;Tumor Markers;tumor microenvironment;Tumor Subtype;Tumor Tissue;Up-Regulation;Visceral;Weight;Woman

PROJECT_TITLE: Body composition and breast cancer survival: immune and metabolic biomarkers in breast tumors

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: BENNETT, DAVID ALAN (contact)

PROJECT_TERMS: Academic Medical Centers;Achievement;Address;Administrator;Advisory Committees;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Biological Markers;Black Populations;Brain;Clinical Research;clinical translation;Clinical Trials;cohort;Cohort Studies;Collaborations;collaborative environment;Communication;Communities;Data;data hub;Dementia;design;Development;Diagnosis;Disease;education research;Ensure;Etiology;Exercise;Faculty;Family Study;Funding;Funding Mechanisms;Future;Generations;Genetic Diseases;Goals;health equity;Infrastructure;innovation;Institution;International;Investments;Knowledge;Latino;Leadership;meetings;Monitor;National Institute on Aging;neuroimaging;new therapeutic target;Pathogenesis;pharmacologic;Phenotype;Population Study;Precision Health;precision medicine;Reporting;Research;Research Institute;Research Personnel;Resource Sharing;Resources;Review Committee;Rotation;Scholars Program;summer internship;user-friendly

PROJECT_TITLE: Core A: Administrative Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Eukaryotic genomes are comprised, in large part, of non-coding and highly repetitive DNA that is essential for vital cellular processes such as chromosome segregation and the maintenance of genome integrity. Disruption of this so-called “satellite DNA” can cause chromosomal abnormalities that lead to birth defects and transitions to cancer. This proposal integrates evolution and cell biology to reveal how satellite DNA shapes vital cellular processes.

PI_NAMEs: BRAND, CARA  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Alleles;Biochemical;Biochemistry;Biological Assay;Biology;Candidate Disease Gene;Cell Physiology;Cellular biology;Chromosome abnormality;Chromosome Segregation;Chromosomes;Complex;Congenital Abnormality;CRISPR/Cas technology;crosslink;Development;DNA;DNA Damage;DNA Repair;DNA Repair Pathway;DNA Sequence;DNA-protein crosslink;Drosophila genus;Drosophila melanogaster;Evolution;Family member;Female;functional restoration;Gene Family;Genes;Genetic;Genome;genome integrity;genome sequencing;Germ Lines;Hybrids;Immunologic Factors;innovation;Internet;Interphase;Lesion;Life;Maintenance;Malignant Neoplasms;Mediating;Modeling;mutant;Oogenesis;Ovary;pathogen;Peptide Hydrolases;Phylogenetic Analysis;Phylogeny;Play;Postdoctoral Fellow;preservation;Process;protein crosslink;Proteins;Recurrence;repaired;reproductive;Research;Resolution;Role;Satellite DNA;Scanning;Shapes;Side;Sister;Stretching;System;Tandem Repeat Sequences;Testing;Time;Transgenes;Trees;Untranslated RNA;Vision;whole genome;Work;X Chromosome

PROJECT_TITLE: Causes and consequences of intra-genomic coevolution


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative Many children with T-cell acute lymphoblastic leukemia (ALL) are not cured and chemotherapy is already very strong with many side effects. Curing more children requires new medicines and not more of the same, and we recently discovered that a drug called dasatinib is very good at fighting cancer cells from children with T-ALL with few toxicities. In this project, we propose to figure out which children with T-ALL are likely to respond to dasatinib and this information will help us develop individualized therapy for this cancer.

PI_NAMEs: TEACHEY, DAVID T.;YANG, JUN J. (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: ABL1 gene;Accounting;Acute Lymphocytic Leukemia;Acute T Cell Leukemia;Algorithms;antagonist;B-Cell Acute Lymphoblastic Leukemia;BCL-2 Protein;BCL2 gene;Biological Markers;Biology;biomarker driven;biomarker performance;biomarker validation;cancer cell;Cells;Characteristics;chemotherapy;Child;Childhood;Childhood Leukemia;chimeric antigen receptor T cells;Clinical;clinical translation;Clinical Trials;Clinical Trials Cooperative Group;cohort;Combination Drug Therapy;Combined Modality Therapy;conventional therapy;Coupling;CRISPR screen;Cytotoxic agent;Cytotoxic Chemotherapy;cytotoxicity;Dasatinib;Data;Data Set;Dependence;Development;Drug resistance;drug testing;Exhibits;experience;fighting;Gene Expression Profile;Gene Expression Profiling;gene network;Genes;genome-wide;genomic data;genomic profiling;Genomics;Heterogeneity;high risk;improved;in vivo;Inferior;inhibitor;innovation;insight;Knowledge;leukemia;leukemia treatment;Lymphocyte-Specific p56LCK Tyrosine Protein Kinase;Malignant Childhood Neoplasm;Malignant Neoplasms;Medicine;Modeling;Molecular;next generation;novel;novel therapeutics;patient derived xenograft model;patient population;Patients;Pediatric Oncology Group;personalized cancer therapy;Pharmaceutical Preparations;Phenotype;Phosphoproteins;Phosphorylation;Quality of life;Refractory;Relapse;Reporting;Research Personnel;Resistance;resistance gene;Resources;response;Role;Series;side effect;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Survival Rate;Systems Biology;Testing;Therapeutic;therapeutic target;Tissue-Specific Gene Expression;Toxic effect;transcriptome sequencing;treatment response;Tyrosine Kinase Inhibitor;Up-Regulation;Validation;Variant;whole genome;Work

PROJECT_TITLE: Biomarkers of dasatinib response and resistance in T-cell acute lymphoblastic leukemia

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


PHR: The Pilot & Feasibility (P&F) program provides pilot research grants in response to meritorious applications from junior faculty scientists, to established investigators who are new to diabetes, and established diabetes investigators who want to test new high-impact hypotheses. The goal is to promote career development of scientists conducting diabetes research and to augment research quality, quantity, and funding at UAB. To-date we have funded 78 pilot awards since 2008 which has led to important discoveries regarding the pathophysiology, treatment, and prevention of diabetes and cardiometabolic diseases.

PI_NAMEs: FRANK, STUART J (contact)

PROJECT_TERMS: Affect;Animals;Applications Grants;Area;Award;Basic Science;Biometry;Cardiometabolic Disease;career;career development;clinical center;Clinical Research;Clinical Sciences;Communities;design;Development;Diabetes Mellitus;Diabetes prevention;Discipline;Eligibility Determination;Environment;epidemiologic data;Epidemiology;Extramural Activities;Faculty;Fostering;Functional disorder;Funding;Goals;Grant;Growth;Health system;Human;human tissue;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Investigation;Laboratories;member;mid-career faculty;novel;Peer Review;Pilot Projects;Population;Prevention;Process;Productivity;Program Reviews;programs;recruit;Reporting;Research;research and development;Research Design;Research Personnel;Research Project Grants;Resources;response;Review Committee;Scientist;success;synergism;Testing;Time;tool;translational pipeline;Translational Research;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: Pilot and Feasibility Program


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative HMMER and Infernal are widely used software tools for proﬁle-based sequence analysis that many protein, RNA, and DNA sequence family databases depend on. Proﬁle analysis software and sequence family databases turn vast amounts of available genome sequence information systematically into deep multiple alignments of many thousands of sequences, and deep alignments are enabling exciting rapid progress in molecular function and structure prediction, based on comparative analyses of subtle patterns of variation and conservation. As part of continued development of HMMER and Infernal as foundational tools for proﬁle analysis of biological sequence families, we propose three new lines of research to improve accuracy, utility, and computational efﬁciency of these methods.

PI_NAMEs: EDDY, SEAN R (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Address;Algorithms;Amino Acid Sequence;Architecture;Base Sequence;Biological;Coiled-Coil Domain;Communities;comparative;Complex;computational pipelines;Computer Analysis;Computer software;Computers;Computing Methodologies;Consensus;Consensus Sequence;Conserved Sequence;Data;Data Set;Databases;design;Development;Distant;distributed model;DNA;DNA Sequence;Elements;Evolution;Face;Family;flexibility;Genome;genome annotation;genome-wide;Growth;Homologous Gene;Human;improved;Laboratories;large datasets;Life;markov model;Memory;Methods;Modeling;Modernization;Molecular;molecular sequence database;novel strategies;Pattern;Performance;Phylogenetic Analysis;programs;Proteins;Reading;Research;Research Personnel;Resources;RNA;RNA Recognition Motif;RNA Sequences;RNA-Binding Proteins;Running;Sampling;Sequence Alignment;Sequence Analysis;Sequence Homologs;Sequence Homology;single-cell RNA sequencing;Software Tools;Speed;Statistical Models;Structure;Taxes;Tertiary Protein Structure;three dimensional structure;Time;tool;Variant

PROJECT_TITLE: HMMER and Infernal: Finding distant homologs of sequences and RNA structures

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ORG_CITY: Columbus

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Non-small cell lung cancer (NSCLC) is a highly aggressive disease with dismal prognosis due to treatment resistance and disease recurrence. Tumor hypoxia has been associated with anti-cancer treatment resistance for decades, yet its role in clinical management of NSCLC remains largely unexplored. Because we identified that nuclear genes encoding mitochondrial oxidative phosphorylation (OXPHOS) subunits are amplified at high frequency in NSCLC patient samples with high levels of hypoxia, we propose to validate the computational data by engineering expression levels of genes that were found to amplified and will investigate the impact on oxygen consumption rates, levels of hypoxia and treatment resistance of mouse NSCLC tumor models.

PI_NAMEs: BENEJ, MARTIN  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Address;anti-cancer treatment;Area;Automobile Driving;Award;Cancer cell line;Cancer Patient;cancer therapy;Cell Line;Cessation of life;Clinical Management;clinical translation;Computer Analysis;Consumption;cytotoxic;Data;Data Engineering;Data Set;Diagnosis;Disease;disorder control;Dose;Engineering;experimental analysis;Foundations;Frequencies;Gene Amplification;Gene Dosage;Genes;Genotype;Genus Hippocampus;Human;Hypoxia;image guided;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;immune resistance;Immune Targeting;Immunotherapy;Impairment;In Vitro;in vivo;Infiltration;inhibitor;innovation;Knowledge;Luciferases;malformation;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Messenger RNA;Metabolic;Methods;Mitochondria;Modeling;Monitor;Mus;nanoprobe;Non-Small-Cell Lung Carcinoma;novel;novel marker;Nuclear;overexpression;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;pharmacologic;Prognosis;programmed cell death protein 1;Proliferating;Proteins;Radiation therapy;Recurrent disease;Refractory;Refractory Disease;Reporter;Research;Role;Sampling;standard of care;System;T cell infiltration;Testing;The Cancer Genome Atlas;therapy resistant;Transgenic Mice;Treatment outcome;treatment response;tumor;tumor growth;tumor hypoxia;tumor microenvironment;Tumor Oxygenation;Tumor Promotion;Tumor-infiltrating immune cells;United States;Validation;validation studies

PROJECT_TITLE: Validation of OXPHOS gene amplification as a driver of hypoxia and treatment resistance in NSCLC


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BARNES, LISA L (contact)

PROJECT_TERMS: Acceleration;Address;African American;Aging;Agreement;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Autopsy;Awareness;Biochemical;Biological;Biological Markers;Black Populations;Blood;Brain;brain magnetic resonance imaging;brain tissue;Cessation of life;Clinical;Clinical Data;Clinical Research;cohort;Collaborations;Communities;County;Data;Data Collection;data hub;data management;data sharing;Dementia;design;Diagnosis;disease model;Disparity;diverse data;DNA;Education;Enrollment;Ensure;Epidemiology;epigenomics;ethnic diversity;Etiology;experience;Funding;Genomics;Goals;Health Disparities Research;health disparity;health equity;Heterogeneity;high risk;human data;Impaired cognition;improved;in vivo;knowledge base;Latino;Link;Magnetic Resonance Imaging;Memory;men;Mentorship;metabolomics;Methods;Minority;Molecular;Molecular Profiling;motor impairment;multidisciplinary;Nature;neuroimaging;neuropathology;Normalcy;older adult;Older Population;Online Systems;open data;outreach;Participant;Pathogenesis;Pathway interactions;personalized approach;Population;predictive modeling;Process;Productivity;programs;Proteomics;public-private partnership;racial diversity;Recommendation;Recording of previous events;recruit;religious order study;Reporting;Research;research clinical testing;Research Personnel;Research Project Grants;research study;Resources;response;Risk Factors;Science;Source;Specimen;Strategic Planning;Structure;success;Time;tool;Training;Underrepresented Populations;underserved community;virtual;Woman

PROJECT_TITLE: Core B: Clinical Core


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE We encounter a wide diversity of chemicals throughout our lives, but we are not yet equipped to understand which of these chemicals actually pose health risks. Furthermore, for the chemicals known to produce human disease, we do not fully understand how they lead to adverse outcomes. This project will systematically evaluate the toxicity of thousands of chemicals and discover the biological networks they modulate to help the research and regulatory communities predict the toxicity of relevant chemicals.

PI_NAMEs: TANGUAY, ROBYN L (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Adolescent;adverse outcome;Animals;Biological;Body System;Cell Culture Techniques;Chemical Exposure;Chemical Warfare;Chemicals;Communities;Computers;CRISPR/Cas technology;Data;drug development;Drug Metabolic Detoxication;Embryo;Environmental Health;experimental study;Gene Expression;Gene Targeting;Genes;Goals;Health;Human;Human Biology;human disease;Informatics;Knock-out;Lead;Libraries;Machine Learning;Mammals;Methods;National Institute of Environmental Health Sciences;overexpression;Pathway interactions;Pharmacologic Substance;Phenotype;Physiology;public database;Research;Risk;Rodent;Scientific Advances and Accomplishments;Scientist;Structure;Testing;Toxic effect;Toxicology;Uncertainty;Work;Zebrafish;zebrafish genome

PROJECT_TITLE: Discovering Chemical Activity Networks-Predicting Bioactivity Based on Structure


ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Not required as per the guidelines.

PI_NAMEs: WANG, HUILIANG  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Animals;Area;Award;Blood;Brain;cell injury;Cells;Chemicals;Color;Craniotomy;design;Disease;Economics;Endosomes;Extracellular Space;Focused Ultrasound;Gene Expression;Genes;Goals;Guidelines;Heart;Hydrogen Bonding;Immune response;implantation;improved;Light;Liver;manufacture;Muscle Cells;Names;nanomaterials;nanoparticle;neuroregulation;non-viral gene delivery;optical fiber;optogenetics;plasmid DNA;Polymers;protein protein interaction;Proteins;Research;Research Personnel;Safety;spatiotemporal;Technology;Time;Tissues;ultrasound;United States National Institutes of Health;uptake;Viral;Work

PROJECT_TITLE: Non-Invasive and Non-Viral Sono-Optogenetics


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Autoimmune Disease;Celiac Disease;Clinical Research;Digestive Diseases;Nutrition

ORG_CITY: STANFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Celiac disease is a gluten-induced inflammatory disorder of the small intestine for which no non-dietary therapy exists at present. We seek to advance our understanding of the role of transglutaminase 2 in celiac disease pathogenesis by examining whether enterocyte derived TG2 is the pathogenically relevant enzyme. Our findings have the potential to pave the way for a safe and efficacious therapy for this lifelong disease.

PI_NAMEs: JABRI, BANA ;KHOSLA, CHAITAN  (contact);SOLLID, LUDVIG MAGNE

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: absorption;Active Sites;adduct;Affinity;Antigens;Autoantibodies;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Biochemical;Biological Assay;CD4 Positive T Lymphocytes;Celiac Disease;Cells;Clinical Trials;Collaborations;Complex;cytokine;deamidation;design;dietary;Disease;efficacious treatment;Engineering;Enterocytes;Environment;Environmental Risk Factor;Enzymes;Epithelial Cells;Epithelium;Epitopes;feeding;Generations;Gluten;Goals;HLA-DQ2;Human;In Vitro;in vivo;Inflammatory;inhibitor;Interferon Type II;interleukin-21;intestinal epithelium;Intestines;intraepithelial;Isotope Labeling;jejunum;Laboratories;Location;Lymphocyte;Modeling;mouse model;Mus;Myelogenous;neutralizing antibody;next generation;novel;Organoids;Pathogenesis;Pathogenicity;Patients;Peptides;Peyer's Patches;Pharmaceutical Preparations;Play;Polymers;Proteins;prototype;Reaction;Reagent;Recombinant Cytokines;Role;scale up;Series;Small Intestines;Source;T-Cell Receptor;T-Lymphocyte;Testing;Time;TNF gene;transglutaminase 2;Villous Atrophy;volunteer

PROJECT_TITLE: Localizing Pathogenically Relevant Transglutaminase 2 in Celiac Disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: LEURGANS, SUE E. (contact)

PROJECT_TERMS: Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Biochemical;Biological Markers;Clinical;Collaborations;Communities;Data;Data Collection;Data Element;data hub;data management;Data Set;data sharing;Database Management Systems;Databases;design;Development;Diagnosis;Dictionary;Documentation;education research;electronic data;Electronics;Equipment and supply inventories;Etiology;flexibility;Foundations;Funding;Generations;Goals;Grant;image processing;improved;Industry;innovation;Latino;Maintenance;Molecular;neuroimaging;neuropathology;normal aging;Online Systems;open data;operation;Outcome;outreach;Participant;Pathogenesis;Process;Publications;recruit;relational database;religious order study;Reporting;repository;Research;Research Personnel;Resource Sharing;Resources;Schedule;secondary analysis;Secure;Services;Specimen;Statistical Computing;statistical service;statistics;success;Summary Reports;Support System;System;tool;United States National Institutes of Health;web site

PROJECT_TITLE: Core C: Data Management and Statistical Core


NIH_SPENDING_CATS: Cancer;Contraception/Reproduction;Estrogen;Fibroid Tumors (Uterine);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Uterine leiomyomas occur in approximately 77% of all women in the United States and can cause severe morbidity and infertility, particularly in Black women. In this proposal, we will study the importance of reactive oxygen species (ROS) on initiating leiomyoma tumor development as well as studying how sex hormones, estrogen and progesterone allow the growth of leiomyoma tumors despite the toxic effects of ROS. With this knowledge, we can specifically target this pathway with existing drugs that will clear leiomyoma cells that are under ROS stress.

PI_NAMEs: KIM, JI-YONG JULIE (contact);WEI, JIAN-JUN

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Acetates;Acetylation;Acute;Address;Age;analog;Area;BCL2 gene;Biological;Black race;black women;Cell Death;Cell Survival;Cells;Cessation of life;Chromatin;Chronic;Data;debilitating symptom;deep sequencing;Development;Disease;Disproportionately impacts women;DNA;DNA Sequence Alteration;Drug Metabolic Detoxication;Environment;Enzymes;Estrogens;Ethnic Origin;Europe;Event;Exons;Fibroid Tumor;Genes;Genomic DNA;Genomic Instability;GNRH1 gene;Gonadal Steroid Hormones;Growth;High Prevalence;high risk population;Homeostasis;Hormones;Hysterectomy;Incidence;Infertility;inhibitor;insight;Knowledge;Knowledge acquisition;Learning;Leiomyoma;Medical;Medical Care Costs;Mitochondria;mitochondrial metabolism;Molecular;Molecular Analysis;Morbidity - disease rate;Mutation;Mutation Analysis;Myometrial;myometrium;novel;Nucleotides;OGG1 gene;Oxidative Stress;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Play;Premenopause;Prevention strategy;Production;Progesterone;Progesterone Receptors;Protein Family;Public Health;Publishing;Race;racial difference;racial disparity;racial population;Reactive Oxygen Species;receptor;Regulation;repair enzyme;reproductive;response;Role;Seminal;senescence;senolytics;side effect;Signal Pathway;SOD2 gene;Stress;Superoxide Dismutase;survival disparity;Symptoms;Testing;Time;Tissues;Toxic effect;translational applications;treatment strategy;tumor;tumor growth;tumor initiation;United States;Uterine Fibroids;White Women;Woman

PROJECT_TITLE: Reactive Oxygen Species in the Initiation, Survival and Racial Disparity of Uterine Leiomyoma


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Here, we propose a Center without Walls, entitled Epilepsy Multiplatform Variant Prediction (EpiMVP), spanning five institutions and incorporating expertise from geneticists, clinicians, computational biologists, neuroscientists, stem cell biologists, pharmacologists and electrophysiologists who have a proven track record of collaborative publications and grants, as well as stature as leaders of national and international epilepsy organizations. EpiMVP will develop a modular, highly integrated platform approach to accelerate determination of the functional, pharmacological, neuronal network and whole animal consequences of genetic variants among a range of clinical epilepsy types. Our ultimate goal is to devise an effective platform for testing the pathogenicity of variants of uncertain significance in non-ion channel, non-receptor genes implicated in epilepsy and for identifying potential targets for future intervention.

PI_NAMEs: ISOM, LORI L. (contact);PARENT, JACK M

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acceleration;Animals;Benign;Biodiversity;Biological;Biological Process;Brain;candidate selection;Cell Line;Cells;Classification;Clinical;clinical care;ClinVar;Communication;Communities;Computer Models;Data;Data Analyses;data modeling;Development;Disease;disease mechanisms study;DNA sequencing;early onset;Epilepsy;exome sequencing;Experimental Models;Family;Future;gene discovery;gene panel;Genes;genetic counselor;genetic testing;genetic variant;Goals;Grant;Guidelines;Human;human disease;human pluripotent stem cell;In Vitro;in vivo Model;induced pluripotent stem cell;innovation;Institution;International;Intervention;Intractable Epilepsy;Ion Channel;Ligands;Machine Learning;machine learning model;Molecular Biology;Needs Assessment;Neurons;new therapeutic target;next generation;novel strategies;novel therapeutics;Organoids;Outcome;Pathogenicity;Pathway interactions;Patient Care;Patients;personalized medicine;pharmacologic;pre-clinical;Pre-Clinical Model;predictive modeling;predictive tools;Proteins;Publications;receptor;Services;stem cells;System;Testing;tool;Variant;variant of unknown significance;Work


PI_NAMEs: ISOM, LORI L. (contact)

PROJECT_TERMS: Advisory Committees;California;Caring;Clinical;clinical care;Collaborations;Communication;Communities;Computational Biology;data sharing;Development;diversity and inclusion;Electrophysiology (science);Epilepsy;epileptic encephalopathies;Ethics;Faculty;Family;Funding;Genes;Genetic;genetic variant;graduate student;Grant;Guidelines;Health Professional;Human;Individual;Information Dissemination;Infrastructure;Institution;International;Journals;Leadership;Legal;Link;medical schools;Medicine;meetings;member;Mentors;Mentorship;Michigan;Mission;National Institute of Neurological Disorders and Stroke;Neurology;Neurosciences;next generation;Other Genetics;Outcome;outreach;Parents;patient advocacy group;Patients;Pharmacology;Postdoctoral Fellow;Principal Investigator;Productivity;programs;Publications;Publishing;Reporting;Research;Research Personnel;Resources;San Francisco;Science;Scientist;success;symposium;tool;Training;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Variant;Washington;web site;Woman;Work

PROJECT_TITLE: Epilepsy Multiplatform Variant Prediction (EpiMVP) - Admin Core


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE Addictions to cigarettes and opioids are public health epidemics. The goal of this study is to identify gene networks that predispose individuals to these addictions. We will leverage cutting-edge methods (such as Explainable Artificial Intelligence), large-scale genome-wide association data in living subjects, and multiple omics data in postmortem human brain to further our understanding of the neurobiology underlying addiction.

PI_NAMEs: HANCOCK, DANA B (contact);JACOBSON, DANIEL A

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Address;Adult;Affect;Algorithms;Attenuated;Autopsy;big-data science;Biological Markers;Brain;brain tissue;Cessation of life;ChIP-seq;Cigarette;cigarette addiction;cigarette smoking;Complex;Cotinine;Data;data integration;DNA Methylation;Epidemic;explainable artificial intelligence;Frequencies;Gene Expression Regulation;gene network;Genes;Genetic;Genetic Epistasis;Genome;genome wide association study;genome-wide;genomic locus;Genotype;Genotype-Tissue Expression Project;Goals;Heritability;Human;improved;Individual;insight;Intelligence;International;Knowledge;Laboratories;Maps;Methods;Morbidity - disease rate;mortality;Multiomic Data;multiple omics;Mus;Neurobiology;Nicotine Dependence;non-smoker;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid overdose;opioid use;Oranges;Outcome;Pharmaceutical Preparations;Prefrontal Cortex;Public Health;random forest;Reporting;Research;Sample Size;Signal Transduction;Smoker;Smoking;smoking addiction;smoking initiation;supercomputer;symposium;Systems Biology;Testing;Time;Tissues;Toxicology;transcriptome sequencing;United States;Variant;Youth

PROJECT_TITLE: Integrating Multiple Omics to Illuminate Gene Networks Underlying Cigarette Smoking and Opioids.


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE A substantial proportion of the growing elderly population have Alzheimer's disease or related dementias (ADRD), and their progressive daily challenges to meeting essential needs (e.g., managing finances, medication, transportation) are exacerbated when they live alone and thus lack cohabitants who can compensate for the cognitive impairment, leading to emergent problems including untreated medical conditions, self-neglect, malnutrition, falls, and fires. To help address this large and growing problem, the proposed research will elucidate key barriers and facilitators to accessing and using long-term services and supports (LTSS) for older adults with ADRD, especially those who live alone and racial/ethnic minorities. The results of this study will support policies to increase access, affordability, acceptance, and use of essential LTSS for these vulnerable populations. 1

PI_NAMEs: PORTACOLONE, ELENA  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Address;Administrator;Adult Children;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Asian population;Black Populations;Child;Cognition;cohort;Communities;community advisory board;Compensation;Consultations;cost;Data;design;Development;development policy;Distress;Education;Elderly;Ensure;ethnic minority;Ethnic Origin;Ethnic Population;falls;Family;Family member;family support;Fire - disasters;Friends;Future;Health;Health and Retirement Study;health disparity;Health Services Accessibility;Heterogeneity;high risk;Home Health Aides;Hospitalization;human old age (65+);Impaired cognition;Individual;informant;Institutionalization;Interview;Knowledge;Latino Population;Link;Lived experience;Living Arrangement;Malnutrition;Medicaid;Medical;meetings;Methods;Modeling;older adult;Older Population;Outcome;participant observation;Performance;Personal Satisfaction;Persons;Pharmaceutical Preparations;Policies;policy recommendation;Population;Positioning Attribute;Provider;Public Health;Race;racial minority;racial population;Reduce health disparities;Reporting;Research;Rural;self neglect;Services;Social Workers;Spouses;Structure;Transportation;United States;urban residence;Vulnerable Populations

PROJECT_TITLE: Access and use of long-term services and supports for older adults living alone with Alzheimer's disease and related dementias from four racial/ethnic groups

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: SCHNEIDER, JULIE A. (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Arterioloscleroses;Atherosclerosis;Autopsy;Biological Markers;biomarker development;Blood;Blood Vessels;Brain;brain tissue;Catalogs;Cerebral Amyloid Angiopathy;Cerebrospinal Fluid;Cessation of life;Clinical;Collaborations;Collection;Communication;Communities;Consent;Data;data management;Data Management Resources;data sharing;Development;Diagnosis;Diagnostic;digital;DNA;Drug or chemical Tissue Distribution;education research;Educational Materials;Faculty;flexibility;Funding;Goals;Hemorrhage;Home;Image;Image Analysis;indexing;Individual;Infarction;innovation;Institution;International;Intervention;Laboratories;Latino;Lewy Bodies;Lymphocyte;Mentors;Methods;Microscopic;Modernization;neuroimaging;neuropathology;open data;outreach;Participant;Pathologic;Pathology;Photography;Play;preservation;Prevention;Procedures;Process;recruit;religious order study;Reproducibility;Research;Research Personnel;research study;Resources;Role;sample collection;Secure;Slide;Special needs;Specimen;tool;Translational Research

PROJECT_TITLE: Core D: Neuropathology Core


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: ROSS, MARGARET ELIZABETH (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Algorithmic Software;Algorithms;Animal Model;Animals;ASCL1 gene;Benign;Biochemical;Biological;Biological Assay;Biological Models;Cell Differentiation process;Cell Line;cell motility;Cell Survival;cell type;Cells;Cellular Assay;Cellular Morphology;Characteristics;Clinical;clinically significant;Co-Immunoprecipitations;Complex;Data;diagnostic criteria;differentiation in vitro;differentiation protocol;disease-causing mutation;DNA;Doxycycline;Elements;Epilepsy;Evaluation;experimental study;Fractionation;FRAP1 gene;Frequencies;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic variant;Glutamates;Goals;Human;human pluripotent stem cell;human reference genome;Impairment;improved;in silico;In Vitro;in vitro Model;in vivo;Individual;Induced Neurons;inhibitory neuron;insertion/deletion mutation;Interdisciplinary Study;Intervention;Knock-out;loss of function;loss of function mutation;member;Modeling;Motility;multi-electrode arrays;mutant;Mutation;Neurons;next generation sequencing;Open Reading Frames;overexpression;Parents;Pathogenesis;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phenotype;Pre-Clinical Model;Precision therapeutics;predictive tools;Property;protein expression;protein function;protein protein interaction;protein transport;Proteins;Research Personnel;RNA Splicing;Rodent Model;screening;Signal Transduction;Single Nucleotide Polymorphism;SNAP receptor;stem cell proliferation;synaptogenesis;syntaxin binding protein 1;System;Testing;therapeutic evaluation;tool;transcriptome sequencing;two-dimensional;Variant;variant of unknown significance;Zebrafish

PROJECT_TITLE: Genes to Proteins


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: PARENT, JACK M (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Address;Affect;Biological Assay;Biological Models;Calcium;Cell Line;Cell Physiology;Cells;clinically relevant;Complex;Computer Analysis;CRISPR interference;Development;Diagnosis;Disease;DNA sequencing;Electrophysiology (science);Epilepsy;exome;experience;expression vector;Future;gamma-Aminobutyric Acid;gene discovery;Gene Expression;Gene Mutation;Genes;Genetic;genetic disorder diagnosis;genetic variant;Genome;Glass;Goals;Human;human pluripotent stem cell;Image;In Vitro;in vitro testing;in vivo;in vivo evaluation;Induced Neurons;inhibitory neuron;Ion Channel;knock-down;Knock-out;loss of function;Microelectrodes;Modeling;Morphology;multi-electrode arrays;Neuroglia;Neurons;next generation;Organoids;Parents;patch clamp;Pathogenicity;Patients;Phenotype;Precision therapeutics;Proteins;Publishing;Reagent;Rodent;Slice;small molecule;Stem Cell Assay;System;Testing;Therapeutic Studies;tool;transcription factor;Variant;variant of unknown significance;Work;Zebrafish

PROJECT_TITLE: Proteins to Cell Systems


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Human Respiratory Syncytial Virus (RSV) is a major contributor to acute respiratory tract infections and disproportionately impacts infants, young children, elderly, and immunocompromised individuals. Immune dysregulation and lack of immunity to reinfection are hallmarks of RSV disease and effective treatments for RSV infections are currently lacking. Our multidisciplinary work will identify mechanisms modulating host responses by RSV nonstructural protein NS1 and identify previously unrecognized therapeutic targets.

PI_NAMEs: LEUNG, DAISY W (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: Acute;Adopted;Animal Model;Anti-viral Response;Antibodies;Attenuated;Binding;Biochemical;Biochemistry;Cell Culture Techniques;Cell Nucleus;cell type;Cells;Child;Childhood;Chromatin;Complex;Development;Disease;effective therapy;Elderly;Enhancers;Epigenetic Process;epigenetic regulation;epigenome;Exportins;Exposure to;Future;Genes;Genetic;Genetic Transcription;Genomics;global health;Goals;Health;Human;human pathogen;Immune;Immune Evasion;Immune response;Immune Response Genes;Immunity;Immunocompromised Host;immunoregulation;Impairment;Individual;Infant;Infection;insight;Integration Host Factors;interferon antagonist;Interferons;Knowledge;Licensing;Lung;Mediator;member;Methods;Modeling;Molecular;Monoclonal Antibodies;Mononegavirales;multidisciplinary;multiple myeloma M Protein;mutant;Mutation;Nonstructural Protein;novel;Nuclear;nucleocytoplasmic transport;paralogous gene;Pathology;Physiological;Play;Pneumovirus;Population;Positioning Attribute;prevent;promoter;prophylactic;Proteins;Pulmonology;recombinant virus;Regulatory Element;Resolution;Respiration;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory syncytial virus RSV proteins;Respiratory Tract Infections;response;Roentgen Rays;Role;Shapes;Signal Transduction;structural biology;Structure;therapeutic target;tool;trafficking;transcription factor;Transcriptional Regulation;transcriptome;vaccine development;Viral;Viral Genome;Viral Pathogenesis;Viral Proteins;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Mechanisms of Host Response Modulation by RSV Non-Structural Proteins

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


PI_NAMEs: GLOVER, CRYSTAL M (contact)

PROJECT_TERMS: Address;advocacy organizations;Advocate;age related;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Back;Biological Markers;biomedical referral center;Black race;Caregivers;Catchment Area;Chicago;Clinical;Cognitive;Collaborations;Communities;community building;community engagement;data management;Dementia;design;Diagnosis;Education;education research;effectiveness evaluation;Etiology;Goals;Latino;Leadership;meetings;Methodology;metropolitan;mild cognitive impairment;National Institute on Aging;neuroimaging;neuropathology;normal aging;Office of Administrative Management;older adult;outreach;Participant;Pathogenesis;Persons;programs;recruit;religious order study;repository;Research;Research Personnel;Resources;Science;Services;Shapes;Survey Methodology;Underrepresented Populations

PROJECT_TITLE: Core E: Outreach, Recruitment, and Engagement Core


PI_NAMEs: WANG, YU  (contact)

PROJECT_TERMS: 3-Dimensional;Behavioral;Benign;Biochemical;Biological;Biological Assay;Biological Models;Brain;Calcium;Cells;childhood epilepsy;Classification;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cortical Dysplasia;D Cells;Data;Diagnosis;Disease Outcome;DNA sequencing;drug discovery;Electrophysiology (science);Electroporation;Embryo;Epilepsy;Exhibits;Explosion;Fishes;Future;gene discovery;Gene Mutation;gene-editing approach;Genes;Genetic;Genetic Counseling;genetic variant;Goals;Human;human disease;Image;in silico;in utero;In Vitro;in vitro Model;in vivo;in vivo evaluation;in vivo Model;Intellectual functioning disability;Knowledge;Laboratories;loss of function;machine learning model;Mediating;model organism;Modeling;Mutagenesis;mutant;Mutation;Nature;next generation;Partial Epilepsies;Pathogenicity;Phenotype;Pre-Clinical Model;Probability;Proteins;Rattus;Recommendation;Rodent;Rodent Model;Seizures;Syndrome;syntaxin binding protein 1;System;Testing;treatment strategy;two-dimensional;Uncertainty;Variant;variant of unknown significance;Zebrafish

PROJECT_TITLE: Cell Systems to Pre-Clinical Models


ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Immune non-responder HIV-1 infected persons (INR), aged individuals, do not recover CD4 Tcell count after ART and remain at greater risk for morbidity and mortality. We found enrichedlevels of gut-derived bacterial toxins in the plasma of those patients. We will explore if these toxins have a role in lowering CD4 T cell count in INR and contribute to morbid outcome.

PI_NAMEs: YOUNES, SOUHEIL ANTOINE (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adult;Affect;aging population;Amino Acids;antiretroviral therapy;Apoptosis;Attenuated;Bacteria;Bacterial Toxins;Bifidobacterium;Biological Assay;Caspase;CD3 Antigens;CD4 Positive T Lymphocytes;Cell Count;Cell Culture System;Cell Cycle;Cell Death;Cell Death Induction;Cell Proliferation;Cell Separation;Cell Survival;cell type;Cells;Cessation of life;Characteristics;Circulation;Citric Acid Cycle;clinical investigation;clinical research site;cohort;commensal bacteria;comorbidity;Consumption;Creatinine;Cresol;Crista ampullaris;cytokine;Cytosol;Data;Diet;DNA;DNA Damage;dysbiosis;Electron Microscopy;experimental study;Feces;Frequencies;gene induction;General Population;Genes;Genus Hippocampus;Golgi Apparatus;gut bacteria;gut microbiome;gut microbiota;HIV;HIV-1;Immune;Immune Plasma;Immunology procedure;Impairment;In Vitro;in vitro testing;Incubated;Indican;Individual;Induction of Apoptosis;Infection;Inflammatory;inflammatory modulation;Interferons;IRF3 gene;Journals;Kidney;kidney dysfunction;Lactobacillus;Lymphopenia;Mass Spectrum Analysis;Measures;Memory;memory CD4 T lymphocyte;Metabolic;metabolic profile;metagenomic sequencing;Metagenomics;metaproteomics;Methods;microbial;microbiota;microscopic imaging;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial fitness;Mitochondrial Proteins;Modeling;Modification;Monitor;Morbidity - disease rate;mortality;multiple omics;Mutation;novel;nutrition;Older Population;Outcome;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Phenylalanine;Plasma;prevent;Probability;Procedures;Production;protein expression;Proteins;Publishing;Recovery;recruit;Regimen;Reporting;resident commensals;response;Response Elements;Ribosomal DNA;Risk;Role;Ruminococcus;Sampling;single-cell RNA sequencing;Sorting;stool sample;Structure;Sulfate;systemic inflammatory response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;Toxic effect;Toxin;transcriptome sequencing;transcriptomics;Tyrosine;urinary

PROJECT_TITLE: Commensal microbiome impact on CD4 T cell lymphopenia in HIV-1 infection

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]