NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Pediatric

PI_NAMEs: BROTMAN, MELISSA  (contact)

PROJECT_TERMS: Address;Affect;Aftercare;Age;Anxiety;Anxiety Disorders;Articulation;associated symptom;Attention;Award;Behavior Therapy;Behavioral;Behavioral Mechanisms;bench to bedside;Benchmarking;Brain;brain based;Child;Childhood;Clinic;Clinical;clinical phenotype;Clinical Trials;Cognitive;cognitive enhancement;Cognitive Therapy;Complex;Coupled;Data;Data Analyses;Development;Diagnosis;digital;Ecological momentary assessment;Event;Exhibits;Extinction;Foundations;Frustration;Functional Magnetic Resonance Imaging;Future;Goals;Human;Impairment;Intervention;Learning;Manuscripts;Mental disorders;Metabolic;mobile application;mobile computing;negative affect;neural;neuromechanism;Neurosciences;nonhuman primate;novel;novel therapeutics;Outcome;overtreatment;Paper;Pathologic;Patients;Pharmaceutical Preparations;Phenotype;Process;programs;Protocols documentation;psychologic;Public Health;Publications;Publishing;Randomized;Randomized, Controlled Trials;response;Sampling;Scanning;side effect;smartphone based assessment;Social Environment;Standardization;Symptoms;Taxonomy;Technology;Testing;Time;Translating;translational neuroscience;Treatment Efficacy;treatment response;visual tracking;Work;Writing;Youth

PROJECT_TITLE: Unit on Neuroscience and Novel Therapeutics


ACTIVITY: ZIA

ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Opioids;Serious Mental Illness

ORG_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

PI_NAMEs: TEJEDA, HUGO  (contact)

PROJECT_TERMS: Ablation;Adaptive Behaviors;addiction;Adult;Affect;Affective;Agreement;antagonist;Arousal;Automobile Driving;Behavior;Behavioral;behavioral response;Bipolar Disorder;Calcium;cell assembly;cell cortex;Cell Physiology;cell type;Cells;Charge;Chronic stress;Classification;clinically relevant;Cognition;Cognitive;coping;Corpus striatum structure;Cues;delta opioid receptor;Desire for food;Discrimination;Disease;Disinhibition;Dopamine;Dopamine D1 Receptor;dopamine D3 receptor;Dopamine Receptor;Dynorphins;Electrophysiology (science);emotion regulation;Emotional;emotional behavior;Emotions;endogenous opioids;Enkephalins;Etiology;experience;Foundations;Fright;Gene Expression;Genetic;Goals;hedonic;Human;Image;imaging approach;Impairment;in vivo imaging;interest;Interneurons;kappa opioid receptors;knock-down;Knock-out;Knowledge;Laboratories;Learning;Life Experience;Ligands;maladaptive behavior;Mediating;Memory;Mental Depression;Mental disorders;Mission;Modeling;monoamine;Mood Disorders;motivated behavior;Motivation;mu opioid receptors;Mus;negative affect;Neuromodulator;Neurons;Neuropeptides;neuropsychiatric disorder;neuroregulation;novel;novel strategies;Nucleus Accumbens;Opioid Peptide;Outcome;Pathway interactions;Peptides;Physiological;Population;Prefrontal Cortex;presynaptic;Presynaptic Terminals;Procedures;psychologic;Psychological reinforcement;Psychotic Disorders;receptor;Receptor Activation;Receptor Signaling;recruit;Reporting;response;Retrieval;reward processing;Rewards;Role;Schizophrenia;sensor;Shapes;Signal Transduction;Site;Somatostatin;Somatostatin Receptor;Stress;stress reactivity;Substance Use Disorder;Synapses;Synaptic Transmission;System;Therapeutic Effect;transmission process;Ventral Striatum;Viral;Work

PROJECT_TITLE: Unit of Neuromodulation and Synaptic Integration


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: INNIS, ROBERT  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Adoption;analysis pipeline;Archives;Articulation;Atlases;Automation;Autopsy;Award;Brain;Brain imaging;BRAIN initiative;Bypass;cohesion;Collaborations;Communities;Computer software;Consumption;Data;data acquisition;Data Analyses;data analysis pipeline;data archive;data curation;data format;data repository;Data Science;Data Set;data sharing;data standards;data structure;Deposition;Documentation;Ensure;expiration;Feedback;Functional Magnetic Resonance Imaging;Funding;Future;General Hospitals;Genes;Goals;Grant;Guidelines;Human;Image;imaging facilities;imaging modality;improved;Individual;Institution;interest;International;Intramural Research Program;invention;Journals;Lateral;Literature;Magnetic Resonance Imaging;Manuals;Maps;Massachusetts;molecular imaging;Molecular Target;Motion;National Institute of Mental Health;neuroimaging;Online Systems;Paper;Persons;pharmacokinetic model;Plasma;Positron-Emission Tomography;Preparation;prevent;Process;publication formats;Publishing;Quality Control;radioligand;Recommendation;Regulation;Reporting;repository;Reproducibility;Research Personnel;Running;Sampling;Security;Sensory Receptors;shared repository;software systems;Source;Specific qualifier value;Standardization;symposium;targeted imaging;Testing;Time;tool;Transcript;United States National Institutes of Health;Universities;University Hospitals;user-friendly;Work

PROJECT_TITLE: BRAIN project: OpenNeuroPET: An Archive for PET data


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences

PI_NAMEs: LOPEZ-GUZMAN, SILVIA  (contact)

PROJECT_TITLE: State-dependent interoception, value-based decision-making, and introspection


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Depression;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Psychosis;Rare Diseases;Schizophrenia;Serious Mental Illness

PI_NAMEs: BARTLEY, CHRISTOPHER  (contact)

PROJECT_TERMS: Affect;Age of Onset;Antibodies;antibody diagnostic;Antibody Repertoire;Antipsychotic Agents;Area;Auditory Hallucination;Autoantibodies;Autoimmune;Autoimmune encephalitis;Autoimmunity;Autopsy;Award;Bacteria;Bacteriophage T7;Basic Science;Behavior;bench to bedside;Benchmarking;biobank;Biological Markers;Blinded;Blood;Blood specimen;Brain;Brain Diseases;Carrier Proteins;Catalogs;Catatonia;Cell Line;Cerebrospinal Fluid;Child;Clinical;clinical diagnostics;clinical phenotype;Clinical Research;Collaborations;Collection;college;Data Set;Delusions;Dendrites;Diagnosis;differential expression;Disease;Down's Syndrome;Dyskinetic syndrome;Encephalitis;Engineering;Epitopes;Evaluation;Focal Neurologic Deficits;Funding;fungus;Generations;Glial Fibrillary Acidic Protein;Health;Hippocampus;Human;Immune;Immunoglobulin A;Immunoglobulin G;Immunologic Factors;Immunological Models;Immunophenotyping;Immunoprecipitation;Impaired cognition;indexing;Individual;Infection;Interview;lead candidate;Letters;Libraries;Los Angeles;Lyme Disease;Magnetic Resonance Imaging;Major Depressive Disorder;Malignant Neoplasms;Manic;Maps;Measures;Mediating;Medicine;Memory impairment;Mental Depression;Mental disorders;Methods;Microbe;model organism;Modeling;Molecular Conformation;Monoclonal Antibodies;Movement Disorders;multiple omics;N-Methyl-D-Aspartate Receptors;nanoluciferase;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;National Institute of Mental Health;neural;neuroimaging;neuroimmunology;neuroinflammation;Neurology;Neurons;neuropsychiatric disorder;neuropsychiatry;next generation;novel;Nucleotides;Obsessive-Compulsive Disorder;Oligonucleotides;Parasites;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections;Pediatric Hospitals;Penetration;Peptides;Performance;Pharmaceutical Preparations;Phase;Phenotype;Plasma;programs;prospective;Protein Array;Protein Isoforms;Protein Secretion;Proteins;Protocols documentation;Psychiatric Diagnosis;psychiatric symptom;Psychoses;psychotic;Recording of previous events;Research;Research Activity;research and development;response;Rheumatism;Sampling;Schizoaffective Disorders;Schizophrenia;schizophrenia spectrum disorder;Seizures;seropositive;Serum;Signal Transduction;Site;Specificity;Standardization;Streptococcus;suicide victim;Symptoms;System;Technology;technology platform;Testing;translational research program;United States National Institutes of Health;Validation;Virus;Visual Hallucination;Woman;Work

PROJECT_TITLE: Translational Immunopsychiatry Unit


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences

PI_NAMEs: LANGDON, ANGELA  (contact)

PROJECT_TERMS: Adaptive Behaviors;addiction;analog;Animals;Anxiety;Back;Behavior;Behavioral;Brain;Brain region;clinically relevant;Cognitive Science;cohort;Collaborations;Complex;Compulsive Behavior;Computer Models;Corpus striatum structure;data acquisition;Decision Making;Dopamine;E-learning;Educational process of instructing;Electrophysiology (science);Environment;Equilibrium;Event;flexibility;Future;Goals;graduate student;Human;human subject;Individual Differences;insight;International;Intramural Research Program;Learning;learning algorithm;Maps;Measures;meetings;member;Mental disorders;Modeling;motivated behavior;National Institute of Mental Health;neural;neural circuit;neural correlate;neuromechanism;Neuromodulator;novel;Outcome;Participant;Patient Self-Report;Persons;phenomenological models;Play;Postbaccalaureate;preference;Prefrontal Cortex;Process;programs;Psychological reinforcement;Publishing;Rattus;recruit;Reporting;Research;Rewards;Rodent;Series;Shapes;Signal Transduction;Statistical Models;Structure;symposium;Symptoms;Testing;theories;translational model;United States National Institutes of Health;Universities;Update;Work

PROJECT_TITLE: Unit on Neural Computations in Learning


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

PI_NAMEs: BOURNE, JAMES  (contact)

PROJECT_TERMS: Acute;Adult;Anatomy;Area;area striata;Attention;Behavior;Behavioral;Birth;Brain;Brain region;burden of illness;Cell Nucleus;Cells;Clinical;Coffee;Cognitive;cognitive function;Collection;Complex;Conscious;Cortical Blindness;Data;Development;Disease;Engineering;experimental study;extrastriate visual cortex;Eye;Functional disorder;Genetic;grasp;hazard;Health;Hearing;Human;Inferior;insight;Laboratories;Lateral;Lesion;Life;life span;Link;Magnetic Resonance Imaging;Maps;Medial;Mental disorders;Mental Health;millisecond;Modeling;Molecular;Monitor;Motor;Neocortex;neocortical;Nervous System Disorder;neural;neurodevelopment;Neurodevelopmental Disorder;Neuronal Plasticity;Neurons;new technology;news;Pathogenicity;Pathology;Patients;Persons;Physiological;Physiology;Play;postnatal development;preservation;Process;programs;Psychologist;Pulvinar structure;Reaction;Reading;repaired;Research;Residual state;Retina;Role;Route;Schizophrenia;Seminal;Shapes;skills;Speed;Stream;Symptoms;System;Technology;Telephone;Textbooks;Texture;Thalamic Nuclei;Thalamic structure;theories;Therapeutic;tool;Touch sensation;Tracer;Unconscious State;United States National Institutes of Health;Vision;vision development;Visual Cortex;visual information;visual motor;Visual Perception;visual processing;Visual System;Visually Impaired Persons;Work

PROJECT_TITLE: Section on Cellular and Cognitive Neurodevelopment


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Mental Health;Mental Illness;Multiple Sclerosis;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: MERSON, TOBIAS  (contact)

PROJECT_TERMS: Ablation;Action Potentials;Adult;AMPA Receptors;Anterior;Area;Astrocytes;autism spectrum disorder;Axon;Binding;Biochemical;Brain;burden of illness;cell regeneration;Cells;Central Nervous System;Communication;Complex;Corpus Callosum;CSPG4 gene;Cuprizone;cytokine;Data;Demyelinations;depressive symptoms;Development;Disease;Dorsal;Electrophysiology (science);Exhibits;experience;functional outcomes;Genetic;Glutamates;Goals;Health;Impairment;Individual;Injury;Interest Group;Intervention;Knowledge;Learning;LIF gene;Ligands;Link;Major Depressive Disorder;Mediating;Mental Health;Methods;migration;Molecular;Morphology;Multiple Sclerosis;Mus;Myelin;Myelin Sheath;myelination;National Institute of Mental Health;Nerve Degeneration;Nerve Regeneration;nerve stem cell;Nervous System Disorder;neural network;Neuroglia;Neurologic;Neuronal Plasticity;Neurons;neurotransmitter release;novel;oligodendrocyte progenitor;Oligodendroglia;Pathologic;Pattern;PDGFRA gene;Pharmacogenetics;Play;Population;postsynaptic;Prevention strategy;Process;programs;Proliferating;Property;Prosencephalon;psychologic;Purinoceptor;receptor;recombinase;regenerative;remyelination;repaired;Research;response;Rodent;Role;Schizophrenia;Signal Transduction;Speed;stem cell differentiation;stem cell population;stem cell proliferation;stem cell self renewal;stem cells;Structure;subventricular zone;Synapses;System;Testing;Thinness;tool;Transgenic Organisms;Ventricular;vesicular release;Viral;white matter;working group

PROJECT_TITLE: Oligodendroglial Interactions Group


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Eating Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Women's Health Research

PI_NAMEs: WHITE, TONYA  (contact)

PROJECT_TERMS: Adolescent;adolescent with autism spectrum disorder;Affect;Amygdaloid structure;Anorexia Nervosa;Anterior;Anxiety;associated symptom;Attention;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic;autistic children;Behavior;Behavioral;Brain;Brain Mapping;brain overgrowth;Brain region;Centers for Disease Control and Prevention (U.S.);Cerebellum;Characteristics;Chemicals;Child;Child Rearing;Childhood;cingulate cortex;Clinical;Cognition;Cognitive;cognitive development;cognitive testing;cohort;Collaborations;Communities;comorbidity;conduct problem;connectome;Corpus Callosum;COVID-19 pandemic effects;Data;Data Set;design;Development;Diffusion Magnetic Resonance Imaging;Disease;dual diagnosis;Education;Electroencephalography;Electrophysiology (science);Environment;Etiology;Family;Female Adolescents;Fingerprint;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;gender diverse;General Population;Generations;Genetic;girls;Goals;Heritability;Heterogeneity;Human;Hyperactivity;infection risk;Infrastructure;Insula of Reil;International;Interview;large datasets;life span;longitudinal analysis;longitudinal dataset;Longitudinal Studies;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Magnetoencephalography;Manuscripts;Measures;meetings;Mental Depression;Mental Health;Methods;Modality;Modeling;Monozygotic twins;Nature;Neurobiology;neurochemistry;Neurodevelopmental Disorder;neuroimaging;Neuropsychology;Neurosciences;non-genetic;open data;pandemic disease;Paper;Parents;Pattern;Plasticizers;Population;Prefrontal Cortex;pressure;Printing;Protocols documentation;Psychopathology;Publications;Publishing;Questionnaires;recruit;Registries;Reporting;Research;Review Committee;Review Literature;Role;Sampling;Severities;sexual dimorphism;Site;Sleep;social;Statistical Models;Stochastic Processes;Structure;Subgroup;symposium;symptomatology;Symptoms;System;Techniques;Testing;Thalamic structure;Twin Multiple Birth;United States;United States National Institutes of Health;Universities;Virginia;Virus Diseases;visual tracking;Work;Writing;young adult;young woman;Youth

PROJECT_TITLE: Research within the Section on Social and Cognitive Developmental Neuroscience


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Mental Health;Neurosciences;Opioids;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: ALVAREZ, VERONICA  (contact)

PROJECT_TERMS: Absence of pain sensation;Affect;Agonist;Attenuated;Basal Ganglia;Behavior;behavior influence;Behavioral Assay;Brain;cell type;Chemosensitization;cholinergic;Cocaine;cocaine self-administration;Compulsive Behavior;Consumption;Corpus striatum structure;Cre-LoxP;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;dopamine D3 receptor;dopaminergic neuron;drug of abuse;Environment;experimental study;Exploratory Behavior;GABA-B Receptor;gamma-Aminobutyric Acid;Goals;Hyperactivity;improved;In Situ Hybridization;Locomotion;Macaca;Mediating;mesolimbic system;Microdialysis;Midbrain structure;Mission;Motivation;Mus;neural circuit;Neurobiology;Neuromodulator;neuronal excitability;Neurons;Nicotinic Receptors;nonhuman primate;novel;Nucleus Accumbens;Opioid;optogenetics;Oxycodone;oxycodone self-administration;Periodicity;Pharmaceutical Preparations;pharmacologic;Photometry;Physiologic pulse;Play;Population;postsynaptic;Predisposing Factor;presynaptic;Presynaptic Receptors;Property;receptor;receptor expression;Research;response;Reverse Transcriptase Polymerase Chain Reaction;Rewards;Rodent;Role;Scanning;sensor;Shapes;Signal Transduction;Slice;Substance of Abuse;Substance Use Disorder;substance use prevention;Synapses;synaptic function;Synaptic plasticity;Techniques

PROJECT_TITLE: Section on Neurobiology of Compulsive Behaviors


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Depression;Mental Health;Mental Illness

PROJECT_TERMS: Adult;Anxiety;Behavior;Clinical;clinically relevant;Cognition;Cognitive;Collaborations;comorbidity;comparison control;computational neuroscience;Computer Models;computerized;Computing Methodologies;Data;Data Set;Decision Making;diagnostic tool;Dimensions;discounting;Discrimination;Disease;Evaluation;experimental study;financial incentive;Goals;Home;Human;Incentives;Individual;Individual Differences;Internet;Intervention;Joints;Judgment;Learning;Major Depressive Disorder;Measures;Mental Depression;Mental disorders;Mental Health;metacognition;Modeling;Neurosciences;novel;Obsessive-Compulsive Disorder;Participant;Patient Self-Report;Patients;Performance;posters;preference;Process;Protocols documentation;Psychiatry;Psychological reinforcement;Reporting;Research Design;Risk;Running;Sampling;social;Societies;Substance Use Disorder;symposium;Testing;Training;trait;Uncertainty;United States National Institutes of Health;Visual;Withdrawal;Work

PROJECT_TITLE: Introspection and decision-making: value-based decision-making and confidence computations


NIH_SPENDING_CATS: Mental Health;Neurosciences;Opioids

PROJECT_TERMS: Acute;Affinity;Agonist;Amphibia;Behavior;Behavioral;Biological Assay;Bradykinin;Bradykinin B2 Receptor;Brain;candidate validation;cell type;Cells;cellular imaging;Chimera organism;Communities;Electrophysiology (science);endogenous opioids;Engineering;Esthesia;experimental study;Exposure to;Extracellular Space;G-Protein-Coupled Receptors;Go Alpha Subunit;Human;in vivo;information processing;Knowledge;Learning;Ligands;Light;Memory;Methods;Modification;mu opioid receptors;Mus;neural circuit;Neurons;Neuropeptides;Neurosciences;Opioid Peptide;Opioid Receptor;Optics;optogenetics;Perception;Play;postsynaptic;presynaptic;Procedures;receptor;Receptor Signaling;Research;Role;Second Messenger Systems;Signal Transduction;Slice;Source;Synapses;Synaptic Transmission;System;Testing;tool;tool development;trafficking;Validation;Viral;viral gene delivery;Viral Vector

PROJECT_TITLE: Trans-synaptic optogenetic control of user-defined pre- and post-synaptic partners


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autoimmune Disease;Biomedical Imaging;Brain Disorders;Cancer;Dementia;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Multiple Sclerosis;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: JACOBSON, STEVEN  (contact)

PROJECT_TERMS: Acceleration;aged;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Amyloid beta-Protein;Anatomy;Animal Model;Animals;Anti-viral Agents;Antibody Formation;Antibody Response;Antigens;Autoimmune;Autoimmune Diseases of the Nervous System;Autoimmunity;Automobile Driving;autoreactivity;B lymphoid malignancy;B-Cell Lymphomas;Binding;Biological Assay;Biological Markers;Biological Specimen Banks;Biology;Blood Banks;Brain;brain tissue;Callithrix;Callithrix jacchus jacchus;CD8-Positive T-Lymphocytes;Central Nervous System;Central Nervous System Diseases;chemokine;Chronic;chronic infection;Circulation;Clinical;Clinical Trials;Collaborations;comparative;comparison control;Control Animal;cytokine;Data;demographics;Demyelinations;Development;digital;Disease;Disease Progression;DNA Polymerase Inhibitor;Drug usage;Early Diagnosis;early onset;Encephalitis;Epilepsy;Exhibits;experimental analysis;Experimental Autoimmune Encephalomyelitis;Experimental Models;exposed human population;exposure route;Exposure to;Future;gammaherpesvirus;Generations;Genetic;Herpesviridae;Herpesviridae Infections;HHV-6A;HHV-6B;Human;Human Herpesvirus 6;Immune;Immunize;immunogenic;Immunologics;Infection;Inflammatory;interest;Intravenous;Investigation;Lesion;Liquid substance;Lymphocryptovirus;Lymphoma;Lymphoproliferative Disorders;Magnetic Resonance Imaging;Malignant neoplasm of brain;Mediating;Methods;Microbe;Modality;Modeling;Monitor;Mucous body substance;Mucous Membrane;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Myelin;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;nonhuman primate;Nose;novel therapeutics;Oncogenic Viruses;Onset of illness;Pathogenesis;Pathogenicity;Pathologic;Pathology;Peptides;Peripheral;Peripheral Blood Mononuclear Cell;PET/CT scan;Phenotype;Physiological;Plasma;pre-clinical;preclinical study;Predisposition;Prevalence;Preventive measure;Property;Proteins;Radiology Specialty;Relapse;Reporting;Rodent;Role;Route;Saliva;Senile Plaques;small molecule inhibitor;Symptoms;System;T-Lymphocyte Subsets;tau Proteins;Testing;Therapeutic;Time;United States National Institutes of Health;Universities;Viral;Viral Antigens;viral DNA;Viral Load result;Viral reservoir;Virus;Virus Diseases;Virus Receptors;white matter;X-Ray Computed Tomography

PROJECT_TITLE: Immunologic Mechanisms In Experimental Autoimmune Diseases Of The Nervous System


ORG_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

PI_NAMEs: SIBLEY, DAVID  (contact)

PROJECT_TERMS: Affinity;Agonist;Allosteric Site;Amphetamines;analog;Animal Model;antagonist;Antipsychotic Agents;Attention deficit hyperactivity disorder;Attenuated;behavior test;beta-arrestin;Binding;Binding Sites;Biochemical;Biological Assay;Biological Availability;Brain;Catalepsy;Chemicals;Clinic;design;Development;Diabetes Mellitus;disability;Docking;Dopamine;Dopamine Agonists;Dopamine Antagonists;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;Dose;DRD4 gene;drug candidate;drug craving;Drug Kinetics;Drug Receptors;effective therapy;Exhibits;FDA approved;functional loss;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;Half-Life;high throughput screening;Illness impact;Impaired cognition;in vivo;Investigation;Lead;Ligands;Link;Locomotion;Mediating;Membrane;Mental disorders;Metabolism;Minor;Modeling;Molecular;Molecular Bank;Motivation;Motor;Movement;Mus;Mutagenesis;mutant;Mutate;Mutation;Nervous System Disorder;Neurons;neuropsychiatry;Neurotransmitters;novel;novel therapeutics;Oral;Output;Parents;Parkinson Disease;Patients;Penetrance;Penetration;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Plasma;Point Mutation;Population;positive allosteric modulator;pre-clinical;prepulse inhibition;programs;protein activation;radioligand;receptor;receptor binding;receptor expression;Receptor Signaling;recruit;Regulation;Research;Rewards;scaffold;Schizophrenia;Sedation procedure;Sequence Homology;side effect;Signal Transduction;simulation;Site;Site-Directed Mutagenesis;small molecule;small molecule libraries;Structure;Substance Use Disorder;Symptoms;System;Testing;Therapeutic;trafficking;United States National Institutes of Health;Validation;Weight Gain;Work

PROJECT_TITLE: Molecular And Pharmacological Studies Of Dopamine Receptors


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Clinical Research;Coronaviruses;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Multiple Sclerosis;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Rare Diseases

PROJECT_TERMS: Adult;Alzheimer's Disease;Amyloid beta-Protein;analysis pipeline;anti-microbial peptide;Anti-Retroviral Agents;Antibodies;Antibody Response;Antibody Specificity;Antigens;Anxiety;Area;Atlases;Atrophic;Autopsy;B-Cell Antigen Receptor;Bioinformatics;Blood;Bone Marrow Transplantation;Brain;brain control;brain fog;cadmium ion;CD28 Antigens;CD44 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Separation;Cells;Central Nervous System Diseases;cerebral atrophy;Cerebrospinal Fluid;Chronic;chronic neurologic disease;Classification;Clinical;Clonal Expansion;cohort;Color;comparison control;Coupled;COVID-19 patient;cytokine;cytotoxic;cytotoxic CD8 T cells;Data;Defect;Dementia;Development;Disease;DNA;Encephalitis;Epilepsy;Etiology;Exhibits;exosome;experience;extracellular;extracellular vesicles;Flow Cytometry;Frequencies;Frontotemporal Dementia;Genomics;Headache;healthy volunteer;Herpesviridae;Heterogeneity;HIV;HLA-A2 Antigen;Human;Human Herpesvirus 4;Human Herpesvirus 6;Human T-lymphotropic virus 1;IL2RA gene;Imaging Techniques;Immune;Immune response;Immunologics;Immunophenotyping;immunoregulation;In Vitro;Individual;infected B cell;Infection;Inflammatory;inflammatory milieu;interest;JC Virus;Length;machine learning method;Magnetic Resonance Imaging;Mediating;Mental Depression;Methods;Microbe;Microfluidics;Molecular;multimodality;Multiple Sclerosis;multiple sclerosis patient;nanoparticle;Nervous System Disorder;neuroinflammation;Neurologic;neurologic sequelae of COVID-19;Neurologic Symptoms;novel;particle;pathogen;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Pattern;Peptides;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Physiologic pulse;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;potential biomarker;Process;Progressive Multifocal Leukoencephalopathy;Regulatory T-Lymphocyte;Relapsing-Remitting Multiple Sclerosis;Reporting;Reproducibility;response;RNA;Role;Sampling;SARS-CoV-2 infection;Senile Plaques;Serum;single cell genomics;single-cell RNA sequencing;Sleep Disorders;Specificity;Spinal Cord;Spinal Cord Diseases;Surface;Symptoms;T-cell receptor repertoire;T-Lymphocyte;Technology;TNFRSF5 gene;training data;transcriptome;transcriptomic profiling;Tropical Spastic Paraparesis;Vesicle;Viral;Viral Antibodies;viral detection;Viral Proteins;viral RNA;Virus;Virus Diseases;Work

PROJECT_TITLE: Involvement Of Human Viruses Associated With Chronic Neurologic Disease


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: WRAY, SUSAN  (contact)

PROJECT_TERMS: Address;Adenylate Cyclase;animal facility;Animals;Award;Axon;Biochemical;Biological Assay;Biological Models;Brain;Calcium;Cell Line;cell motility;Cells;Cellular Neurobiology;chemokine;Chronic;circadian;Collaborations;Coupled;craniofacial development;Cues;Cyclic AMP-Dependent Protein Kinases;Destinations;Development;developmental neurobiology;differential expression;Electrophysiology (science);Event;Female;Fertility;Floods;food restriction;Functional disorder;Future;G-Protein-Coupled Receptors;Gene Expression;Genes;Genetic;Genetic study;Goals;Gonadotropin Hormone Releasing Hormone;graduate student;Hormones;Human;Human Genetics;hypothalamic pituitary gonadal axis;Idiopathic Hypogonadotropic Hypogonadism;Image;In Vitro;in vitro Model;infertility treatment;Knockout Mice;Leadership;Libraries;Link;Location;male;Maryland;Measures;medical schools;member;migration;molecular array;Monitor;Morphology;mouse model;Movement;Mus;Mutate;Mutation;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Nervous System;Neurobiology;Neuronal Differentiation;Neurons;Neurosciences;Neurosecretory Systems;new therapeutic target;Nose;Occupations;Outcome;Paper;patient screening;Patients;Pattern;Peptide Synthesis;Peptides;Phenotype;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phospholipase C;pituitary gonadal axis;Population;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;Process;progenitor;programs;Property;Prosencephalon;Proteins;Puberty;Publishing;receptor;Regulation;Reproduction;reproductive;reproductive function;Research;Review Committee;Route;Science;screening;Series;Services;shift work;Signal Pathway;suprachiasmatic nucleus;symposium;Synapses;Syndrome;System;tool;Training;Transgenic Animals;Universities;Vasoactive Intestinal Peptide;Vasoactive Intestinal Peptide Receptors;Vertebrates;Work

PROJECT_TITLE: Development And Regulation Of The Gonadotropin Releasing Hormone System


NIH_SPENDING_CATS: Bioengineering;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Natural Products;Neurosciences;Pain Research;Therapeutic Cannabinoid Research

PI_NAMEs: SWARTZ, KENTON  (contact)

PROJECT_TERMS: Acceleration;Adopted;Afferent Neurons;Agonist;Amino Acid Sequence;base;Binding;Binding Sites;Biological;Borates;Calcium Channel;Cannabidiol;Cannabinoids;Cardiac;Cations;Cell Physiology;Cells;Central Nervous System;Characteristics;Chemicals;clinically relevant;Collaborations;Coupled;Coupling;Cryoelectron Microscopy;disease-causing mutation;Electrophysiology (science);Elements;Environment;epileptic encephalopathies;Esthesia;Family;Foundations;Goals;Hydrophobicity;icilin;Immune;Immunosuppression;inhibitor;Ion Channel;Ion Channel Protein;Ions;Kv2.1 channel;Ligands;Lipids;mechanical force;Mechanics;member;Membrane Lipids;Molecular;Molecular Conformation;Movement;mutant;Mutation;Nervous System;neuronal excitability;Neurons;new therapeutic target;Nociception;Nociceptors;Pain;Patch-Clamp Techniques;Pathway interactions;Perception;Permeability;Pharmaceutical Preparations;Pharmacology;Phosphatidylinositol 4,5-Diphosphate;Play;Positioning Attribute;Potassium;Potassium Channel;Process;Property;Rationalization;Rattus;Regulation;Reporting;Residual state;resilience;Resolution;response;Role;Schwann Cells;sensor;Sensory;Series;Short-Term Memory;Signal Transduction;simulation;Site;Skin;small molecule;Sodium Channel;Solid;Specificity;Stimulus;Structure;sulfated glycoprotein 2;T-Lymphocyte;Temperature;Temperature Sense;temporal measurement;Therapeutic;Therapeutic Uses;tool;Transmembrane Domain;TRP channel;TRPM5 gene;TRPV1 gene;Vanilloid;voltage;Voltage-Gated Potassium Channel

PROJECT_TITLE: Gating mechanisms and pharmacology of voltage-activated ion channels


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences

PI_NAMEs: SHENG, ZU-HANG  (contact)

PROJECT_TERMS: Address;Age Months;Aging;alpha synuclein;autism onset;autism spectrum disorder;Automobile Driving;Autophagocytosis;Autophagosome;Axon;axonal degeneration;Axonal Transport;axonopathy;Behavioral;Binding;Biological;Biological Models;Cells;Cellular biology;Cholesterol;Chronic;Communication;Complex;Defect;Degradation Pathway;density;Development;Disease;disease phenotype;Disease Progression;Distal;Distant;dopaminergic neuron;Dynein ATPase;Elderly;Event;Exhibits;exome sequencing;experimental study;Face;familial amyotrophic lateral sclerosis;Foundations;Functional disorder;Gene Mutation;Genes;Genetic;Guidelines;Health;Homeostasis;Human;human induced pluripotent stem cells;Hybrids;Image;Impairment;In Vitro;in vivo;in vivo Model;Individual;insight;Intervention;Investigation;Journals;Kinesin;Knock-out;Knockout Mice;Label;late endosome;Lead;Learning;Link;Lipids;LRRK2 gene;lysosome membrane;Lysosomes;Maintenance;Mediating;Membrane;Membrane Lipids;Memory;Modeling;Molecular;Monomeric GTP-Binding Proteins;Motor;motor impairment;Motor Neurons;mouse model;Movement;Mus;Muscle Rigidity;Nature;Neimann-Pick's Disease Type C;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuron loss;neuronal cell body;Neurons;Neurosciences;Onset of illness;Organelles;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;pharmacologic;Phenotype;Play;polarized cell;Positioning Attribute;postsynaptic;Predisposition;Preparation;presynaptic;Presynaptic Terminals;protein aggregation;protein function;Proteins;Psychiatry;recruit;Reporting;Research;response;Rest Tremor;retrograde transport;Role;Scaffolding Protein;Shuffling Gaits;Signal Transduction;SNAPIN gene;social;Solid;Stereotyped Behavior;Stress;Susceptibility Gene;Swelling;Symptoms;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Synaptic Vesicles;synaptogenesis;trafficking;trait;translational applications;ultra high resolution;Variant;Walking

PROJECT_TITLE: Axonal transport of endolysosomal organelles and presynaptic cargos for the maintenance of axon cellular homeostasis and presynaptic function


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Neurosciences

PI_NAMEs: REESE, THOMAS S (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Algorithm Design;Algorithms;Architecture;automated segmentation;Automation;Binding;Bioinformatics;Brain;calmodulin-dependent protein kinase II;Classification;classification algorithm;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Computer software;computerized data processing;computing resources;Cryo-electron tomography;Cryoelectron Microscopy;Darkness;Data;data acquisition;data pipeline;Data Set;Dendritic Spines;density;design;Development;Devices;DLG4 gene;Electron Microscopy;electron optics;electron tomography;Electrons;Elements;Environment;Enzymes;Event;Excitatory Synapse;Exocytosis;Filament;Freezing;Future;Genetic;Glutamate Receptor;Goals;Gold;Hand;Hippocampus;Hour;Image;Image Analysis;image processing;Imaging Techniques;improved;Individual;innovation;insight;Internet;Investigation;Ions;Knock-in;Label;Laboratories;laptop;light microscopy;Link;Machine Learning;Manuals;Maps;Membrane;Memory;Methods;Microscope;Molecular;Molecular Probes;Molecular Structure;Morphology;Motion;nano;nanobodies;nanoGold;nanoscale;Nature;Neurobiology;Neurons;Noise;Organelles;overexpression;particle;postsynaptic;Postsynaptic Membrane;Preparation;presynaptic;Presynaptic Terminals;Process;Progress Reports;Proteins;Publications;Publishing;Rattus;reconstruction;Research;Resolution;response;Rodent;Role;Scanning;Series;Shapes;Sonication;Specificity;Structural Models;Structure;Subcellular structure;supercomputer;Synapses;Synaptic Cleft;synaptic function;Synaptic Membranes;Synaptic plasticity;Synaptic Transmission;Synaptosomes;Tablets;Techniques;Technology;Testing;Thinness;Time;Tomogram;tomography;tool;trafficking;United States National Institutes of Health;usability;Vertebral column;Vesicle;Visualization;Work

PROJECT_TITLE: Macromolecular Architecture  Of The Synapse


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Chronic Pain;Clinical Research;Mental Health;Neurosciences;Pain Research

PI_NAMEs: WASSERMANN, ERIC M (contact)

PROJECT_TERMS: Acute Pain;Affect;Anatomy;Anisotropy;Anterior;Area;Athletic Injuries;Back;Basal Ganglia;Behavior;Behavioral;Belief;Biological Markers;Brain;brain based;Brain region;Cell Nucleus;central sensitization;Cephalic;Chronic Fatigue Syndrome;chronic pain;cingulate cortex;Clinical;Clinical effectiveness;clinically relevant;Cognitive;cognitive skill;cohort;cost;Dental Care;Dependence;Dimensions;Disease;Dopamine;Dose;drug development;Economics;Electrodes;Electroencephalography;Electrophysiology (science);Emotional;Episodic memory;Event;experience;experimental study;Fatigue;Functional Imaging;Functional Magnetic Resonance Imaging;Goals;grasp;Habits;Hippocampus;Home;Human;Impairment;improved;Individual;Individual Differences;Inferior;interest;Intervention;Intervention Trial;Investigation;Knowledge;Lateral;Learning;Maps;Measures;Medial;medial temporal lobe;member;Memory;memory encoding;Midbrain structure;Motivation;Motor Skills;neural;neurobehavioral disorder;neuroregulation;noninvasive brain stimulation;Outcome;Pain;Pain intensity;pain perception;Parietal Lobe;Parkinson Disease;Pathway interactions;Performance;Physical Efforts;Physiological;pre-clinical;Predisposition;Prefrontal Cortex;Production;Punishment;Reaction;Records;Refractory;response;Rest;Retrieval;Rewards;Risk;Route;segregation;Sensory;sensory system;Site;Somatosensory Cortex;Source;Stimulus;Structure;Surrogate Endpoint;synchronous delivery;System;Techniques;Thalamic structure;Time;Training;Transcranial magnetic stimulation;Uncertainty;Update;Ventral Striatum;visual learning;white matter;willingness;Work

PROJECT_TITLE: Electrophysiological Probes And Treatments In Neurobehavioral Disorders


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: KORETSKY, ALAN  (contact)

PROJECT_TERMS: 1 year old;Adult;Affect;Age;age effect;anatomic imaging;Anatomy;animal old age;Animals;Area;Back;barrel cortex;Behavioral;Behavioral Paradigm;Blood Vessels;Brain;Brain Diseases;Brain imaging;Brain region;brain tissue;Cells;cellular imaging;Chemosensitization;Contralateral;Cortical Column;Coupling;critical period;Data;Denervation;Detection;Development;developmental plasticity;discrimination task;Down-Regulation;Electrophysiology (science);Embryo;Endothelial Cells;Excision;Functional Imaging;Functional Magnetic Resonance Imaging;Gene Expression;Goals;gray matter;Growth;Human;Image;Imaging Device;Imaging Techniques;Implant;improved;in vivo;Injury;interest;Ipsilateral;Knowledge;Learning;Limb structure;Magnetic Resonance Imaging;Manganese;Manuscripts;Maps;Measures;migration;Molecular;molecular imaging;Monitor;Motor Cortex;Motor Pathways;Myelin;Nerve;nerve injury;nerve stem cell;nerve supply;neural;Neurons;Neurosciences;Nose;novel;Odors;olfactory bulb;Oligodendroglia;optical imaging;Pathway interactions;Peripheral;Physiology;Population;precursor cell;Process;Professional counselor;recruit;Regulation;repaired;Reporter;Resolution;response;response to injury;Rodent;Rodent Model;Site;Slice;somatosensory;Somatosensory Cortex;stellate cell;stem cells;Stroke;structural determinants;subventricular zone;Synapses;Synaptic plasticity;System;Techniques;Testing;Textbooks;Thalamic structure;Tissues;tool;Translating;Transplantation;Vibrissae;Visualization;white matter;Work

PROJECT_TITLE: Functional Imaging of The Brain


PI_NAMEs: DUYN, JEFF  (contact)

PROJECT_TERMS: Anatomy;Animals;Area;biophysical model;Biophysics;Blood;Brain;brain health;brain iron;brain tissue;Cardiac;Classification;Clinical;Communication;Computer software;contrast enhanced;cryostat;Detection;detector;Development;Devices;Diffusion;Electromagnetic Energy;Enhancement Technology;Equipment;experimental study;flexibility;Generations;Goals;Head;Heating;Helium;Histology;Human;Image;Image Analysis;image reconstruction;improved;in vivo;Iron;Legal patent;Lesion;Liquid substance;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Measurement;Medicine;Methodology;Methods;Motion;Multiple Sclerosis;Myelin;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Nervous System Disorder;neuroimaging;new technology;novel;Pathologic;Patients;Perfusion;Peripheral;Physiologic pulse;Play;Publishing;radio frequency;Ramp;Resolution;response;risk minimization;Role;Sampling;Scanning;Signal Transduction;simulation;Structure;System;Techniques;Technology;technology development;Time;Tissues;transmission process;United States National Institutes of Health;Visualization;water diffusion;Work

PROJECT_TITLE: Magnetic Resonance Imaging Technology Development


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Coronaviruses;Dystonia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: HOLMGREN, MIGUEL  (contact)

PROJECT_TERMS: Action Potentials;Affinity;alternating hemiplegia;Amino Acids;Animals;Arrhythmia;ATP1A1 gene;ATP1A3 gene;Behavioral;Binding;Binding Sites;Biology;Biophysics;Birth;Calcium;Calcium ion;Cardiac;Catalytic Domain;Cations;Cell Death;Cell membrane;Cell Physiology;Cells;Cerebellar Ataxia;Childhood;Cryoelectron Microscopy;Disabling;Disease;Dystonia;Dystonia 12;Electronics;Electrophysiology (science);Encephalopathies;Environment;Enzymes;Epilepsy;experimental study;extracellular;Eye Movements;falls;Fever;Genes;Goals;Heart;Homologous Gene;Human;Hydrolysis;Impaired cognition;Impairment;Integral Membrane Protein;Intellectual functioning disability;Ion Channel;Ion Transport;Ions;K ATPase;Knock-in Mouse;large-conductance calcium-activated potassium channels;Mammalian Cell;Membrane;Membrane Potentials;Membrane Proteins;Membrane Structure and Function;Mitochondria;Molecular;Molecular Conformation;Monitor;Movement;Movement Disorders;Muscle hypotonia;Mutation;Nervous System Disorder;neural;Neurologic;Neurological outcome;Neurotransmitters;Nonstructural Protein;Nutrient;Open Reading Frames;Optic Atrophy;Organelles;Paralysed;particle;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Phosphorylation;Potassium;Probability;Property;Protein Conformation;Protein Dephosphorylation;Protein Dynamics;Protein Isoforms;Proteins;Proteomics;Pump;recruit;Recurrence;Resistance;SARS coronavirus;SARS-CoV-2 genome;sensor;Sensorineural Hearing Loss;Series;Side;Signal Transduction;Site;Site-Directed Mutagenesis;Sodium;spasticity;Structural Protein;Structure;Symptoms;Syndrome;Talipes cavus;Techniques;Tissues;Transmembrane Domain;Transport Process;Variant;Virus Replication;voltage;Work

PROJECT_TITLE: Structure and Function of Membrane Proteins


PI_NAMEs: ROCHE, KATHERINE  (contact)

PROJECT_TERMS: Affect;Amino Acids;AMPA Receptors;autism spectrum disorder;bench to bedside;Binding;Biochemical;Biological;Brain;C-terminal;Central Nervous System;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;comorbidity;Complex;Data;de novo mutation;deep sequencing;Defect;density;Development;Diagnosis;Disease;Epilepsy;Event;excitatory neuron;Excitatory Synapse;exome;experience;experimental study;Family;Frameshift Mutation;Functional disorder;G-Protein-Coupled Receptors;Genes;genome sequencing;Genotype;Glutamate Receptor;Glutamates;Goals;Heterozygote;Hippocampus;Human Genetics;Individual;induced pluripotent stem cell;insight;Intellectual functioning disability;interest;Kainic Acid Receptors;Knock-out;Laboratory Study;Mental disorders;Metabotropic Glutamate Receptors;Methods;Missense Mutation;Molecular;Mus;Mutation;N-Methyl-D-Aspartate Receptors;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurodevelopmental Disorder;Neurons;neuropathology;Neurotransmitter Receptor;Neurotransmitters;NMDA receptor A1;Paper;Pathogenicity;Patients;Persons;Phosphorylation;Play;Post-Translational Protein Processing;programs;protein protein interaction;Proteins;Protocols documentation;public database;Publishing;rare variant;receptor;receptor function;Regulation;Reporting;Research;response;Role;Scaffolding Protein;Site;Stimulus;Stretching;Structure;Surface;Synapses;synaptic function;System;Techniques;Testing;Therapeutic;trafficking;Variant;Vertebral column;whole genome;Work

PROJECT_TITLE: Subunit-Specific Regulation Of Glutamate Receptors


NIH_SPENDING_CATS: Neurosciences

PI_NAMEs: MINDELL, JOSEPH A (contact)

PROJECT_TERMS: antiport;antiporter;Area;Biochemical;Biological Assay;Biological Process;Carrier Proteins;Cell surface;Chlorides;CLC Gene;Collaborations;Defect;dicarboxylate-binding protein;Disease;Electrophysiology (science);Family;Family member;Goals;Homologous Gene;Individual;inhibitor;insight;interest;Ion Channel;Liposomes;Mammalian Cell;Mediating;member;Membrane Potentials;Methods;Molecular Conformation;Movement;mutant;Mutation;Neurons;Patients;pH Homeostasis;pharmacologic;Physiological;Property;protein function;Proteins;proteoliposomes;Protons;Reproducibility;Rest;single molecule;Skeletal Muscle;Structure;Subgroup;Transport Process;Work;Xenopus oocyte

PROJECT_TITLE: Conformational changes in CIC chloride transporters


PI_NAMEs: WU, LING GANG  (contact)

PROJECT_TITLE: Synaptic Vesicle Exocytosis


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: GINIGER, EDWARD  (contact)

PROJECT_TERMS: Actins;Animals;Axon;axon growth;axon guidance;Biophysics;Cell Physiology;Cell surface;Cell Surface Receptors;Cellular biology;Collaborations;Computer Models;Computer Simulation;Computing Methodologies;Cytoskeletal Modeling;Cytoskeleton;Development;Drosophila genus;experimental study;genetic manipulation;Growth;Growth Cones;high resolution imaging;Image;in silico;in vivo;Laboratories;Libraries;Ligands;Link;Modeling;Molecular;Motility;Nerve;neuron development;Neurons;notch protein;Proto-Oncogene Proteins c-abl;Reagent;receptor;Regulation;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;simulation;Structure;Surface;System;Testing;Transgenes;Vertebrates;Wing;Zebrafish

PROJECT_TITLE: Mechanisms of axon guidance during development


NIH_SPENDING_CATS: Congenital Structural Anomalies;Neurosciences;Pediatric;Rare Diseases

PROJECT_TITLE: Chloride fluxes in organellar membranes


PROJECT_TITLE: Gating mechanisms and pharmacology of P2X receptor channels


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Sleep Research

PROJECT_TERMS: Affect;Anatomy;Area;Arousal;Behavioral;Brain;Brain region;brain tissue;Classification;Collaborations;Communication;Data;Data Analyses;Data Set;data sharing;Electroencephalography;Electrophysiology (science);Epilepsy;Event;Exhibits;experience;experimental study;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Goals;Heart Rate;Hippocampus;Hour;human imaging;improved;in vivo;Individual;insight;Iron;Joints;Learning;Link;magnetic field;Magnetic Resonance Imaging;Magnetism;markov model;Measurement;meetings;memory consolidation;Methods;Modeling;movie;Multiple Sclerosis;Mus;Myelin;neural;neural patterning;Neurodegenerative Disorders;Neurologic;Neurons;non rapid eye movement;Operative Surgical Procedures;Parkinson Disease;Participant;Pathology;Pathway interactions;Patients;Pattern;Periodicals;Physiological;Physiology;Pilot Projects;Population;Predisposition;Primary Lateral Sclerosis;Probability;Procedures;Prosencephalon;Publishing;rapid eye movement;Recurrence;Reproducibility;Respiration;response;Rest;Role;Series;Services;Signal Transduction;Sleep;Sleep Stages;Source;Specificity;Structure;success;Techniques;Time;Training;United States National Institutes of Health;Universities;unsupervised learning;Work

PROJECT_TITLE: Magnetic Resonance Imaging of Human Brain Anatomy and Function


NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

PROJECT_TERMS: A kinase anchoring protein;Acceleration;Acute;Address;Adult;adult neurogenesis;Affect;age related;aged;Aging;Alzheimer's Disease;Area;Attenuated;Axon;axon injury;axon regeneration;axonal degeneration;Behavior;Behavioral;Bioenergetics;Biology;Bipolar Disorder;Bipolar Neuron;Brain;Brain Injuries;Brain Ischemia;Brain region;Cell Death;cell regeneration;Cells;Cellular Metabolic Process;Chronic;clinically relevant;Collaborations;Communication;Corticospinal Tracts;Creatine;Deacetylase;Deacetylation;deprivation;disease model;Disease Progression;Distal;Energy consumption;Energy Metabolism;Energy Supply;Ensure;Exhibits;exosome;F-Actin;Face;Failure;Foundations;frontier;Functional disorder;Generations;Genes;Glucose;Growth;healthy aging;Hippocampus;Human;human induced pluripotent stem cells;Impairment;Indiana;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Injections;Injury;Investigation;Ischemia;ischemic injury;knock-down;Knockout Mice;Knowledge;Lead;Lesion;Lithium;Lysosomes;Maintenance;Manic;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular Motors;Moods;Motility;Motor Cortex;Mus;myosin VI;Natural regeneration;Nature;Nerve Degeneration;Nervous System Disorder;Neurobiology;Neurodegenerative Disorders;Neuroglia;neuron regeneration;neuronal cell body;neuronal growth;neuronal survival;Neurons;Neurosciences;newborn neuron;novel;Oligodendroglia;Organoids;Oxidation-Reduction;Oxygen;PAK6 gene;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Phosphorylation;Phosphotransferases;Physiologic pulse;Physiological;Play;Positioning Attribute;Preparation;presynaptic;Presynaptic Terminals;Proteins;Proto-Oncogene Proteins c-akt;Recovery;recruit;Regulation;repaired;Reporting;Research;response;response to injury;restraint;risk variant;Role;Signal Pathway;Signal Transduction;Sirtuins;SLC25A4 gene;SLC25A5 gene;Solid;spatiotemporal;Spinal Cord;Spinal cord injury;Stress;Structure;Synapses;synaptic depression;Synaptic plasticity;Synaptic Transmission;syntaphilin;Testing;Therapeutic;therapeutic target;trafficking;trait;Universities;Variant;Vesicle

PROJECT_TITLE: Mitochondrial transport and energy metabolism in synaptic transmission and neuronal degeneration and regeneration


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Clinical Research;Coronaviruses;Dementia;Emerging Infectious Diseases;Infectious Diseases;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Rare Diseases

PI_NAMEs: GOLDSTEIN, DAVID  (contact)

PROJECT_TERMS: Acute;alpha synuclein;Area;Area Under Curve;Autonomic nervous system;Autopsy;Back;Baroreflex;Behavior;Biochemical;Biological Assay;Biological Markers;biomarker identification;Blood Pressure;Blood specimen;Brain;brain fog;Cardiac;Cardiovascular system;Catecholamines;Catechols;Cellular Assay;Cerebrospinal Fluid;Clinical;clinical center;clinical diagnosis;clinical investigation;Clinical Protocols;Cognitive;cognitive testing;cohort;Collaborations;comparison control;COVID-19;Cutaneous;Data;Dementia with Lewy Bodies;Deposition;Development;Diagnosis;disability;Disease;Disease Progression;Dopamine;Doppler Ultrasound;Dreams;Eligibility Determination;Evaluation;Evolution;experience;Failure;falls;Fatigue;Fiber;follow up assessment;follow-up;Frequencies;Functional disorder;Genetic;Genetic Processes;Head;Heart Rate;heart rate variability;Hypotension;Immune;Immunologics;immunoreactivity;in vivo;indexing;Individual;Inflammatory;Inflammatory Response;Inpatients;interest;Journals;Karnofsky Performance Status;Laboratories;Lewy Body Disease;Long COVID;longitudinal, prospective study;Longterm Follow-up;Magnetic Resonance Imaging;Measurement;Measures;Modification;multimodality;Multiple System Atrophy;Myocardial;National Institute of Allergy and Infectious Disease;National Institute of Neurological Disorders and Stroke;Nerve;Nerve Degeneration;Neurodegenerative Disorders;Neurologic Symptoms;Neurology;Neuropsychology;Neurosecretory Systems;Neurotransmitters;noradrenergic;Norepinephrine;Olfactory dysfunction;Oligoclonal Bands;Orthostatic Hypotension;orthostatic intolerance;Parkinson Disease;Participant;Patient Self-Report;Patients;Pattern;Pennsylvania;Personal Satisfaction;Persons;Phase;Phenotype;Physiological;Plasma;Positron-Emission Tomography;pre-clinical;pressure;prevent;Probability;Process;prospective;Protocols documentation;Publishing;Pure Autonomic Failures;Radioactivity;Rare Diseases;Recovery;Reporting;Research Personnel;response;Risk;Risk Factors;Sampling;Serum;Signal Transduction;Skin;skin biopsy;Smell Perception;Spinal Puncture;Symptoms;synuclein;synucleinopathy;System;Test Result;Testing;Tilt-Table Test;Time;Tissues;Toxic effect;Tyrosine 3-Monooxygenase;United States National Institutes of Health;Universities;Valsalva Maneuver;Visit;web site

PROJECT_TITLE: Biomarkers of Catecholaminergic Neurodegeneration


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Brain Disorders;Clinical Research;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Machine Learning and Artificial Intelligence;Multiple Sclerosis;Nanotechnology;Neurodegenerative;Neurosciences;Rare Diseases

PROJECT_TERMS: Activated Lymphocyte;Africa;Anti-Retroviral Agents;Antibodies;antigen-specific T cells;Antigens;Area;Atrophic;B cell therapy;B-Lymphocyte Subsets;B-Lymphocytes;Bar Codes;Bladder;Blood;brain volume;Carbon Nanotubes;Caribbean region;Catalogs;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Cell Differentiation process;Cells;cerebral atrophy;Cerebrospinal Fluid;Chronic;chronic neurologic disease;Cladribine;Classification;Clinical;clinical outcome measures;Clinical Treatment;Clinical Trials;Clonal Expansion;cohort;Collection;Color;complementarity-determining region 3;convolutional neural network;Coupled;Cytostatics;cytotoxic;Data;deep learning;Diagnosis;Differential Diagnosis;Dihydroorotate Dehydrogenase Inhibitor;disability;Disease;Disease Progression;DNA Binding;Drops;Epidemiology;Epstein-Barr Virus Nuclear Antigens;experience;Fingerprint;Flow Cytometry;forest;Frequencies;Functional disorder;Genomics;healthy volunteer;HIV;HIV-1;HTLV-1 Infection;Human;Human Herpesvirus 4;Human Herpesvirus 6;Human T-lymphotropic virus 1;Immune;immune activation;Immunologics;Immunophenotyping;Immunotherapeutic agent;In Vitro;India;Individual;Inflammatory;inhibitor;Integrase Inhibitors;interest;Intestines;Japan;JC Virus;Laboratories;learning strategy;Life Cycle Stages;Long COVID;lymphoblastoid cell line;Machine Learning;Measurement;Measures;Metabolic;Molecular;Molecular Genetics;MRI Scans;Multiple Sclerosis;multiple sclerosis patient;Nerve Degeneration;Nervous System Disorder;Neurologic;novel;Nucleic Acids;nucleoside analog;Pathogenesis;Pathogenicity;Pathology;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phylogenetic Analysis;Privatization;Process;Progressive Multifocal Leukoencephalopathy;Proliferating;Raman Spectrum Analysis;Retroviridae;Role;Safety;Sampling;single-cell RNA sequencing;Site;small molecule inhibitor;Spastic Paraparesis;Spinal Cord;Spinal Cord Diseases;T cell infiltration;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Taxes;Techniques;Technology;Time;translational study;Translations;treatment strategy;Trees;Tropical Spastic Paraparesis;Viral;Viral load measurement;Virus;virus identification

PROJECT_TITLE: Translational studies of human viruses and chronic neurologic disease


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Precision Medicine;Social Determinants of Health;Stroke

PI_NAMEs: LATOUR, LAWRENCE  (contact)

PROJECT_TERMS: Accident and Emergency department;Acute;acute stroke;Address;Aftercare;Biological;biological systems;Biology;biomarker identification;Blood flow;blood-brain barrier disruption;Brain;Categories;Cerebral Ischemia;Cerebrovascular Disorders;Classification;Clinical;clinical center;Coagulation Process;Collaborations;Communities;Complex;complex biological systems;Data;Data Analyses;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease Marker;drug development;Edema;effective therapy;Embolectomy;Enrollment;Excision;experience;Functional disorder;Future;health care availability;health care disparity;Hemorrhage;Hospitals;Human;Image;imaging biomarker;improved;Injury;insight;interest;Interruption;Intervention;Intravenous;Investigation;Learning;Lesion;Magnetic Resonance Imaging;Mechanics;MicroRNAs;Minor;Modality;Modeling;Motion;National Institute of Neurological Disorders and Stroke;Natural History;neuroimaging;next generation sequencing;novel;Observational Study;Outcome;Participant;participant enrollment;patient population;patient registry;Patient Selection;patient stratification;Patients;peripheral blood;Phenotype;Population;prospective;Prospective Studies;Protocols documentation;Publishing;Reperfusion Therapy;responders and non-responders;response;social health determinants;Speed;standard of care;Stroke;stroke outcome;stroke symptom;stroke therapy;Symptoms;therapy development;Thrombolytic Therapy;Time;Tissue-Specific Gene Expression;Transient Ischemic Attack;treatment responders;treatment response;United States National Institutes of Health;Validation;Withholding Treatment

PROJECT_TITLE: Novel Insights Into Cerebral Ischemic Pathophysiology In Humans


PROJECT_TERMS: Adult;Affect;Anatomy;Animal Model;Animals;Antibodies;antibody detection;Area;arterial spin labeling;Astrocytes;Back;Behavior;blood-brain barrier disruption;Brain;Brain imaging;Brain region;Calcium;cell motility;Cell Physiology;Cells;cellular imaging;Chemicals;Clinical;Collaborations;Complex;contrast imaging;Contrast Media;Coupling;Cues;Data;Dependence;Detection;Development;disease model;Early Diagnosis;Encephalitis;Engineering;Environment;Enzymes;experimental study;Fc Receptor;Functional Imaging;Functional Magnetic Resonance Imaging;Gene Expression;Goals;High Fat Diet;Human;Image;imaging approach;Imaging Techniques;Immunoglobulin G;in vivo;Individual;Inflammation;Injections;interest;Ions;Iron;iron oxide;Label;Lead;light microscopy;magnetic field;Magnetic Resonance Imaging;Magnetism;Manganese;manufacture;Manuscripts;Measurement;Measures;migration;Modeling;Molecular;molecular imaging;Monitor;mouse model;Mus;Nerve Degeneration;nerve stem cell;neural;neuroinflammation;Neurons;New Agents;Nose;novel;novel strategies;olfactory bulb;Paper;particle;Pathway interactions;pre-clinical;preclinical imaging;Process;Property;Publishing;radiological imaging;Rattus;receptor;Recording of previous events;Recovery;Regional Blood Flow;Reporter;Reporting;Research;Resolution;Rodent;Site;Specificity;Stream;subventricular zone;Temperature;Testing;TFRC gene;Time;Toxic effect;Tracer;translational potential;uptake;Vascular Cell Adhesion Molecule-1;Virus;Work

PROJECT_TITLE: MRI contrast for molecular and cellular imaging of the brain


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Neurosciences;Pain Research;Pediatric;Rare Diseases

PI_NAMEs: HEISS, JOHN  (contact)

PROJECT_TERMS: Adhesions;Adhesives;Adopted;Adult;Affect;Appearance;Arachnoiditis;Auditory;Automobile Driving;Brain;Brain imaging;Brain Stem;Candidate Disease Gene;Caring;Cerebellar tonsil;Cerebellum;Cerebrospinal Fluid;cerebrospinal fluid flow;Cerebrospinal Fluid Pressure;Characteristics;Child;Childhood;Chromosomes;Chronic;Cicatrix;Clinical;Clinical Research;cohort;Collaborations;Communication;Complex;Congenital Disorders;cranium;Cyst;Data;data cleaning;Data Set;Development;Disease;Dissection;Dizziness;DNA;Doctor of Medicine;Doctor of Philosophy;Dorsal;Dura Mater;Dyes;Edema;Effectiveness;Endoscopes;Endoscopy;Enrollment;Equilibrium;Etiology;Excision;exome;exome sequencing;Extended Family;Family;Family member;Family Study;flexibility;follow-up;foramen magnum;Functional disorder;Funding;Future;Genetic;genetic linkage analysis;genetic variant;genome sequencing;genome-wide;genomic locus;Genotype;Headache;Hearing;improved;Incidence;Individual;Infection;Laminectomy;Link;Liquid substance;longitudinal, prospective study;Magnetic Resonance Imaging;malformation;Maps;Measures;member;Membrane;Methods;morphological criteria;Morphology;Myelography;National Human Genome Research Institute;Natural History;Neck Pain;neural;Neuroendoscopy;Neurologic Dysfunctions;Neurologic Examination;Obstruction;Operative Surgical Procedures;Outcome;Outcome Measure;pain scale;Paralysed;Pathway interactions;Patient Monitoring;patient population;Patient-Focused Outcomes;Patients;pediatric patients;Phenotype;Population;Posterior Fossa;Postoperative Period;Posture;Procedures;Process;Prognosis;programs;Publishing;Reporting;Research Personnel;Sampling;scoliosis;Sensory;Shapes;Signal Transduction;Signs and Symptoms;somatosensory;Specialist;Specimen;Spinal;Spinal Cord;Structure;Subarachnoid Space;Subgroup;Symptoms;Syringes;Syringomyelia;technique development;Testing;Tonsil;trait;transmission process;Trauma;tumor;United States;Variant;Vertebral column;Vestibular Diseases;vestibular system;Visual;whole genome;women patients

PROJECT_TITLE: Pathophysiology and Treatment of Syringomyelia


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Epilepsy;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Parkinson's Disease;Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: adenovirus mediated delivery;Adverse effects;Affect;afferent nerve;Agonist;Anatomy;Animal Experimentation;Animal Model;Animals;Area;Autopsy;Autoradiography;Behavioral;bench to bedside;Bilateral;Binding;Biopsy;Blood;blood-brain barrier crossing;Botulinum Toxins;Brain;Brain Injuries;Brain Neoplasms;Brain Stem;Brain Stem Glioma;Case Study;Catechols;Catheters;cell type;Central Nervous System;Central Nervous System Agents;Cervical;Cessation of life;Characteristics;Chemicals;Childhood Brain Neoplasm;Chronic;Clinical;clinical candidate;Clinical Protocols;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Consent;Convection;Corpus striatum structure;Deep Brain Stimulation;Degenerative Disorder;design;Development;Diffuse;Diffuse intrinsic pontine glioma;diffuse midline glioma;Disease;Dopamine;dopaminergic neuron;Dose;Drug Delivery Systems;drug development;drug distribution;Drug Monitoring;effectiveness evaluation;Electrodes;Enrollment;Epilepsy;Extracellular Space;Family;Gadolinium DTPA;gamma-Aminobutyric Acid;Gene Expression;gene therapy;Genes;giant axonal neuropathy;glial cell-line derived neurotrophic factor;Glioblastoma;Glioma;Grant;Hippocampus;Histopathology;Human;Image;Immunologics;immunoreactivity;improved;Infusion procedures;Injections;Institution;Interleukin-13;Intractable Epilepsy;Laboratories;Laboratory Animals;Magnetic Resonance Imaging;Malignant Neoplasms;Manuscripts;Measures;Methods;Microdialysis;Modeling;Monitor;Motor;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Muscimol;National Institute of Neurological Disorders and Stroke;Nervous System;Neural Inhibition;neuro-oncology;Neurodegenerative Disorders;Neurologic;Neurons;neuropathology;neurosurgery;Neurotransmitters;neurotrophic factor;non-invasive imaging;non-invasive monitor;nonhuman primate;Oncolytic;Operative Surgical Procedures;palliative;Parkinson Disease;Parkinsonian Disorders;Pathologic;Patients;pediatric patients;Perfusion;Peripheral Nerves;Pharmaceutical Preparations;Pontine structure;Positron-Emission Tomography;Postoperative Period;preclinical study;presynaptic;prevent;Primates;Property;Pseudomonas;Publishing;Pump;Radiation therapy;radiological imaging;real-time images;recruit;regeneration potential;Reporting;Research Personnel;Rodent;Seizures;Signal Transduction;Spondylosis;Structure;Structure of subthalamic nucleus;Study Subject;Synapses;Techniques;Technology;Therapeutic;Therapeutic Agents;Time;time use;Toxic effect;Toxin;Tracer;treatment site;Tumor Tissue;Tyrosine 3-Monooxygenase;Unresectable;uptake;Viral Vector;Virotherapy;Work;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Central Nervous System Drug Delivery Techniques


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Immunotherapy;Neurosciences;Rare Diseases

PROJECT_TERMS: adaptive immune response;AKT inhibition;Animal Model;Anti-Retroviral Agents;antitumor effect;Apoptosis;Arginine;Astrocytes;Autophagocytosis;Basic Science;Brain;Brain Neoplasms;CASP3 gene;Cell Aggregation;Cell Communication;cell growth;Cell Physiology;Cell Proliferation;Cell Survival;Cells;chemosensitizing agent;Chemotherapy and/or radiation;Clinical;Clinical Research;Clinical Trials;Collaborations;cytotoxicity;Defect;Development;diagnostic technologies;diagnostic tool;drug repurposing;Endogenous Retroviruses;Endothelial Cells;Epigenetic Process;epitranscriptome;ERBB3 gene;Etiology;experimental study;Genetic;Genetic Heterogeneity;Glioblastoma;Glioma;Glomerular basement membrane antibody;Head;Heterogeneity;Human;Immune;Immune checkpoint inhibitor;Immunologic Surveillance;Immunology;Immunophilins;Immunotherapy;improved;in vivo;Induction of Apoptosis;Inherited;inhibitor;insight;Investigation;JUN gene;kinase inhibitor;knock-down;Laboratories;Literature;Malignant Neoplasms;Manuscripts;MAPK8 gene;Mediating;Medical;Medical Genetics;medical schools;Melanoma;Modeling;Molecular;molecular diagnostics;Morphology;Mus;Mutation;National Institute of Neurological Disorders and Stroke;Natural Immunity;neoplasm surgery;Neoplasms;neoplastic cell;nervous system infection;neuro-oncology;Neurology;Neurosphere;neurosurgery;new technology;novel;oncolytic herpes simplex virus;Operative Surgical Procedures;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;PD-1 blockade;pharmacologic;Phase I Clinical Trials;Phosphoric Monoester Hydrolases;professor;programmed cell death protein 1;Protein Inhibition;Protein phosphatase;Protein-Arginine N-Methyltransferase;Proto-Oncogene Proteins c-akt;PTEN gene;Publications;Publishing;Radiation-Sensitizing Agents;Regulation;Reporting;Research;Research Personnel;Resistance;Role;self-renewal;senescence;Signal Transduction;Site;small molecule inhibitor;Spinal;Spinal Neoplasms;stem;stem cell niche;summer student;Tacrolimus Binding Proteins;Techniques;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;therapy resistant;Time;Tissues;Translating;Translational Research;tumor;Tumor Biology;tumor heterogeneity;tumorigenesis;United States National Institutes of Health;Universities;vaccine trial;vasculogenesis;Virus;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Molecular Pathogenesis of Neoplasia


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Neurodegenerative;Neurofibromatosis;Neurosciences;Pediatric;Pediatric Cancer;Peripheral Neuropathy;Rare Diseases

PI_NAMEs: CHITTIBOINA, PRASHANT  (contact)

PROJECT_TERMS: Acceleration;Adolescent;Adrenal Glands;Affect;associated symptom;Axonal Neuropathy;bilateral vestibular Schwannoma;Biochemical;Body System;Cataract;Cells;Central Nervous System;Central Nervous System Neoplasms;Chromosomes;Clinical;cohort;Cranial Nerves;Cutaneous T-cell lymphoma;Cyst;Data;Development;Ear;endolymphatic sac;Enrollment;Ependymoma;Evolution;Excision;Extravasation;Fascicle;Future;Gene Mutation;Genetic;Germ Lines;Germ-Line Mutation;Glioma;Growth;Hamartoma;HDAC4 gene;hearing impairment;hemangioblastoma;Histone Deacetylase Inhibitor;Immunohistochemistry;inclusion criteria;Inherited;insight;Kidney;Knowledge;Laboratories;Lesion;longitudinal analysis;Magnetic Resonance Imaging;Mediating;meetings;meningioma;Molecular;Morbidity - disease rate;mutant;Mutate;Natural History;Nature;Neoplasms;Nerve;Nervous System;Nervous System Neoplasms;Neurilemmoma;neuro-oncology;Neurofibromatosis 2;Neurologic Deficit;Neuropathy;novel therapeutics;Operative Surgical Procedures;Oral;Organ;Pancreas;Patient Monitoring;Patients;Pattern;Peripheral;Peripheral Nerves;Peripheral Nervous System Diseases;Peripheral Nervous System Neoplasms;Permeability;Plasma;predictive marker;Predisposition;Prevalence;prospective;Proteins;Refractory;reproductive;Resolution;Retina;Role;Signal Transduction;Spinal nerve structure;Stuttering;symptom treatment;Symptoms;Syndrome;Syringes;Testing;Time;treatment duration;treatment risk;tumor;Tumor Biology;tumor growth;tumor progression;Tumor Suppressor Genes;Tumor Suppressor Proteins;Tumor Volume;Vestibular Nerve;VHL mutation;VHL protein;Visceral;Von Hippel-Lindau Syndrome;Vorinostat;Western Blotting

PROJECT_TITLE: Neuro-oncology of Familial Neoplasia Syndromes


NIH_SPENDING_CATS: Clinical Research;Neurosciences

PROJECT_TERMS: Actins;Address;base;Biological;Biophysics;Calcineurin;Calcium;Calmodulin;Capsid Proteins;Cell membrane;Chromaffin Cells;Classification;Clathrin;Coated vesicle;Communication;constriction;Coupling;Cytoskeleton;Dynamin;Electron Microscopy;Electrophysiology (science);Endocytosis;Exocytosis;Floods;Goals;Hippocampus;Homeostasis;improved;Individual;Kinetics;Maintenance;mathematical model;mechanical force;Mediating;Membrane;Membrane Fusion;Microscope;Modeling;Molecular;nanometer;Nerve;Nervous System;Nervous System Physiology;Neuroendocrine Cell;Neurons;Neurosecretory Systems;Neurotransmitters;Osmotic Pressure;Pathology;Phosphorylation;Physiology;polymerization;Polymers;Probability;Process;Protein Dephosphorylation;Protein Kinase C;Proteins;Recycling;Reporting;Research;Retrieval;Role;Running;Shapes;Signal Pathway;Signal Transduction;Signaling Protein;SNAP receptor;Speed;superresolution imaging;Synapses;Synaptic Transmission;Synaptic Vesicles;Techniques;Time;trafficking;Vesicle;Virus Diseases;Visualization;Work

PROJECT_TITLE: Synaptic Vesicle Endocytosis


PROJECT_TERMS: Adult;age acceleration;age related changes;Aging;aging process;Animals;antioxidant therapy;Autophagocytosis;Axon;Back;Cell Culture Techniques;Cell Physiology;clinical application;Cytoskeletal Modeling;Disease Progression;DNA Sequence;Drosophila genus;electrical property;Event;Exclusion;experimental study;extend lifespan;fly;Future;Genetic;genetic manipulation;Health;Housekeeping;Human;improved;In Vitro;in vivo;in vivo evaluation;insight;Invaded;Mitochondria;Modeling;Molecular;mortality;mutant;Nerve Degeneration;Neurodegenerative Disorders;neurodevelopment;neuron loss;Neurons;Orthologous Gene;Oxidation-Reduction;Oxidative Stress;Pathogenicity;pharmacologic;Play;Population;Process;response;Role;tau-protein kinase;Testing;translational study;Vertebrates

PROJECT_TITLE: Roles of Cdk5 in neurodevelopment and neurodegeneration


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Infectious Diseases;Neurosciences;Rare Diseases

PI_NAMEs: MCGAVERN, DORIAN  (contact)

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Adoptive Immunotherapy;Aging;Autoimmunity;Brain;Cells;Central Nervous System;Central Nervous System Infections;Cephalic;Chronic;chronic infection;Data;Dendritic Cells;design;Deterioration;Disease;Engraftment;Equilibrium;exhaustion;Failure;Fostering;Future;Glioblastoma;Health;HIV;HIV-1;Homeostasis;human pathogen;Humoral Immunities;Immune;Immune response;Immune system;Immunologics;immunopathology;immunoreaction;immunoregulation;Impairment;imprint;In Situ;Infection;Infectious Diseases Research;Infiltration;Innate Immune System;Intention;interest;Laboratories;Laboratory Study;Lymphocytic choriomeningitis virus;Lytic;Macrophage;Maintenance;Meningeal;Meninges;Modeling;monocyte;Mus;neoplastic cell;Nerve Degeneration;Nervous System Physiology;pathogen;Peripheral;preservation;prevent;programs;Property;purge;Resolution;response;response to brain injury;sensor;Sinus;Structure;T-Lymphocyte;Therapeutic;Tissues;tumor;Tumor Immunity;tumor immunology;Tumor Promotion;Viral;Virus;Virus Diseases;wound healing

PROJECT_TITLE: Mechanisms Underlying Clearance of Persistent Infections and Tumors


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Infectious Diseases;Neurosciences;Physical Injury - Accidents and Adverse Effects;Stroke;Traumatic Head and Spine Injury

PROJECT_TERMS: Acute;acute infection;Antibody Response;Area;B-Lymphocytes;Biological;Blood;blood damage;Blood Vessels;bone;Brain;Brain Injuries;brain parenchyma;Candida albicans;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Death;Cell Maturation;Cells;Central Nervous System;Central Nervous System Infections;central nervous system injury;Cerebral hemisphere hemorrhage;Cerebral Malaria;cerebrovascular;Cerebrovascular system;Compensation;Complex;Cortical vasculature;cranium;cytokine;Degenerative Disorder;Dendritic Cells;Disease;Drainage procedure;Dura Mater;efficacy evaluation;Encephalitis;Endowment;Fibrosis;Film;Generations;genetic signature;Genomics;Goals;healing;Health;Human;human disease;imaging approach;Immune;Immune response;Immune system;Immunologics;Immunology;improved;Infection;Inflammatory;Injury;insight;interest;Interferons;Interleukin-6;intravital imaging;Invaded;Laboratories;Laser Scanning Microscopy;Lead;Lesion;Liquid substance;Location;Lymphocytic choriomeningitis virus;Lymphoid Cell;Macrophage;Mediating;Meninges;Meningitis;Microbe;Microglia;Molecular;monocyte;Myeloid Cells;Nerve Degeneration;Nervous System Disorder;Nervous System Physiology;neural;Neurons;neutrophil;pathogen;Pathogenesis;Peripheral;Plasmodium berghei;preservation;Process;Property;Reaction;Recovery;Recovery of Function;repaired;Research;response;Risk;Rodent;Sampling;seal;Signal Induction;Signal Pathway;Signal Transduction;Site;Stroke;Structure;Structure of germinal center of lymph node;System;Therapeutic;therapeutic evaluation;Therapeutic Intervention;Tight Junctions;Time;Tissues;TNF gene;Toxin;transcriptomics;Traumatic Brain Injury;two-photon;vaccine development;VEGFA gene;venous sinus;Vesicular stomatitis Indiana virus;Viral;Visualization

PROJECT_TITLE: Pathogenesis of Acute CNS infection and injury


PROJECT_TERMS: 3-Dimensional;A kinase anchoring protein;Affect;Affinity;AMPA Receptors;analog;Antibodies;Architecture;beta-Hydroxybutyrate;Binding;Binding Sites;biological adaptation to stress;Calcium;Calmodulin;calmodulin-dependent protein kinase II;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Color;Complement;Complex;CRISPR/Cas technology;Cryo-electron tomography;Cryoelectron Microscopy;Cyclic AMP-Dependent Protein Kinases;Darkness;Data;density;DLG4 gene;electron tomography;Elements;Environment;Event;Evolution;Exocytosis;Filament;Fluorescence;Freeze Substitution;Genetic;Glutamate Receptor;Glutamates;Goals;Gold;Hippocampus;Holoenzymes;Image;Immunoelectron Microscopy;Individual;information processing;Inhibitory Synapse;insight;Knock-in;Knock-out;knowledge integration;Label;Learning;Length;Link;Location;Maps;Mediating;Membrane;Memory;Methods;Microtomy;Molecular;Molecular Conformation;molecular dynamics;Molecular Machines;mutant;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;nano;nanobodies;nanoGold;Nervous System;Neurons;Neuroprotective Agents;Neurotransmitters;NMDA receptor A1;novel;NR2B NMDA receptor;particle;Peroxides;Phosphoric Monoester Hydrolases;Phosphotransferases;Phylogenetic Analysis;Physical condensation;Plastic Embedding;Positioning Attribute;postsynaptic;postsynaptic density protein;Potassium;presynaptic;Presynaptic Terminals;Property;protein complex;Protein Isoforms;Proteins;Publications;Reaction;reconstruction;Research;Rest;Rodent;Role;Sampling;Scaffolding Protein;Scanning;Sensory;Signal Transduction;Site;Stains;Structural Models;Structure;Subcellular structure;supercomputer;symposium;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Synaptic Vesicles;Techniques;Time;Tomogram;tomography;trafficking;United States National Institutes of Health;Validation;Vertebral column;Vesicle;Visualization;Work

PROJECT_TITLE: Dynamic Structural Properties of Synapses


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

PI_NAMEs: REICH, DANIEL  (contact)

PROJECT_TERMS: accurate diagnosis;Affect;Age;Animal Model;Animals;Atlases;Autopsy;Axon;biobank;Biology;Blood Vessels;Brain;brain cell;Callithrix;Callithrix jacchus jacchus;Categories;Cell Aging;Cells;Central Nervous System;Central Vein;Cerebral cortex;Cerebral hemisphere;Cerebrospinal Fluid;Cerebrum;Chemicals;Chronic;Clinical;Clinical Trials;CNS degeneration;Collaborations;Communities;complement system;Conduct Clinical Trials;Consensus;Data;Demyelinations;design;Detection;Development;Diagnostic;diagnostic algorithm;disability;Disease;Dura Mater;Evaluation;experimental study;Extramural Activities;Functional disorder;Gene Expression Profile;Goals;Human;Image;imaging biomarker;improved;Industry;Inflammation;Inflammatory;International;Investigation;Lesion;Lipids;Lipofuscin;Liquid substance;Location;Longitudinal Studies;Magnetic Resonance Imaging;Meninges;Methodology;Methods;Microscopy;Modeling;Molecular;multimodality;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;Myelin;National Institute of Neurological Disorders and Stroke;Natural History;Nerve Degeneration;Neuroanatomy;neuroimaging;neuroinflammation;nonhuman primate;novel therapeutics;Onset of illness;Organoids;Outcome;Paper;Pathologic;Pathology;Pathway interactions;Patients;Persons;Phase;Phenotype;Physiologic pulse;Pigments;Play;portability;Positioning Attribute;prevent;Primates;Prognosis;prognostic significance;programs;Publications;Publishing;radio frequency;Radiology Specialty;remyelination;repaired;Reproducibility;Research;Resolution;Resources;Review Literature;Role;Scanning;Selection for Treatments;spatiotemporal;Spectrum Analysis;Structure of choroid plexus;System;systems research;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Three-Dimensional Imaging;Time;Tissues;transcriptomics;ultra high resolution;United States National Institutes of Health;Universities;Veins;Vision;Washington;white matter;Work;Writing

PROJECT_TITLE: Multimodal MRI in Multiple Sclerosis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biomedical Imaging;Brain Disorders;Clinical Research;Emergency Care;Hematology;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PROJECT_TERMS: Accident and Emergency department;Accounting;Acute;acute care;Adult;Area;biomarker identification;Blood;blood-based biomarker;Brain;Brain Concussion;Brain scan;Chronic;Classification;Clinical;clinical center;Cognitive;Cognitive deficits;cohort;Collaborations;cost;Coupled;Craniocerebral Trauma;cytotoxic;Data;Department of Defense;detection sensitivity;Diagnosis;Edema;Enrollment;experience;extracellular vesicles;Follow-Up Studies;Funding;Future;Hematology;Hemorrhage;high resolution imaging;Hospitals;Image;improved;Injury;Institutional Review Boards;Length of Stay;Lesion;Lifelong disability;Long-Term Care;Magnetic Resonance Imaging;Manuscripts;Meningeal;Meninges;mild traumatic brain injury;Names;National Institute of Neurological Disorders and Stroke;Natural History;neuroimaging;Neurosciences;Outcome;Outcome Measure;outcome prediction;Pathogenesis;Pathology;patient population;Patients;Persons;Physiological;Positron-Emission Tomography;Prevalence;Productivity;programs;Prospective Studies;Protocols documentation;Publishing;Quality of life;Radiology Specialty;Recording of previous events;recruit;Regenerative Medicine;Science;screening;Services;severe injury;Severities;Stroke;Study Subject;Subdural space;TBI Patients;therapy development;Trauma;Traumatic Brain Injury;United States;United States National Institutes of Health;Universities;vascular injury;vasogenic edema;Water;Work;X-Ray Computed Tomography

PROJECT_TITLE: Eval, Pathogenesis, Outcome of Subjects with or Suspected Traumatic Brain Injury


PI_NAMEs: YOULE, RICHARD JAMES (contact)

PROJECT_TERMS: Age;aged;Alleles;Animal Model;Autophagocytosis;Autophagosome;autosome;Biological;Cells;Cellular biology;cohort;Collaborations;cytokine;Cytosol;Defect;DNA;dopaminergic neuron;Drosophila melanogaster;Excision;fly;gene product;Genetic Screening;German population;Golgi Apparatus;Idiopathic Parkinson Disease;Immune signaling;Immunity;Impairment;in vivo;Inflammation;Inflammatory;innate immune function;Interferon Type I;Knock-out;Link;Locomotion;loss of function;Mammalian Cell;man;Mediating;Membrane;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;Modeling;Molecular;Morphology;Motor;Mus;Muscle;mutant;Mutate;Mutation;Natural Immunity;Neurodegenerative Disorders;Neurons;neuroprotection;NF-kappa B;novel;Parkin;Parkinson Disease;Pathology;Pathway interactions;Patients;Penetrance;Persons;Phenotype;Phosphotransferases;PINK1 gene;Posture;prevent;Quality Control;recruit;response;restraint;RNA interference screen;Role;sensor;Signal Transduction;small molecule libraries;Testing;ubiquitin-protein ligase;whole genome;Wing;Work

PROJECT_TITLE: Role of mitochondria in neurodegenerative diseases


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

PROJECT_TERMS: Adopted;Affinity;Autophagocytosis;Autophagosome;Bacteria;Biological;Brain;C-terminal;Cell Survival;Cells;Claw;Collaborations;Complex;Cryoelectron Microscopy;cytotoxic;Development;dimer;Ectopic Expression;Encapsulated;Eukaryotic Cell;extracellular;flexibility;Generations;Homeostasis;in vivo;Induced pluripotent stem cell derived human neuron;Investigation;Knockout Mice;Letters;Ligands;Link;Lipofuscin;Lysosomes;Maintenance;Maps;Mediating;Membrane;misfolded protein;Mitochondria;mitochondrial autophagy;Molecular;Molecular Weight;Mus;Mutation;N-terminal;Natural Immunity;Nerve Degeneration;Neurodegenerative Disorders;neuronal survival;Nutrient;Nutrient availability;Organelles;Parkin;Parkinson Disease;Pathway interactions;Pharmaceutical Preparations;Phosphotransferases;PINK1 gene;premature;protein aggregation;Proteins;proteotoxicity;Quality Control;receptor;recruit;scaffold;screening;Shapes;single molecule;Starvation;Stress;TBK1 gene;Therapeutic;Toxic effect;Ubiquitination

PROJECT_TITLE: Mechanisms of Autophagy


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Human Fetal Tissue;Infectious Diseases;Neurosciences

PI_NAMEs: NATH, AVINDRA  (contact)

PROJECT_TERMS: Amyloid beta-Protein;Anti-Retroviral Agents;antiretroviral therapy;Antisense Oligonucleotides;antiviral drug development;Astrocytes;Autopsy;Biological Assay;Blocking Antibodies;Brain;brain tissue;Cell Differentiation process;Cell Line;Cells;Cerebrospinal Fluid;Chromosomes;Chronic;Chronic Fatigue Syndrome;Clinical Protocols;Clinical Trials;Complex;COVID-19;COVID-19 complications;Dengue Infection;Disease;efficacy testing;Encephalitis;Endogenous Retroviruses;env Gene Products;Functional disorder;Gene Activation;Goals;high throughput screening;HIV;HIV Infections;HIV tat Protein;immune activation;immune modulating agents;Immune system;Immunohistochemistry;Impaired cognition;In Vitro;in vivo Model;Individual;inducible gene expression;Infection;Laboratories;Life;Lymphocyte;Maps;MRI Scans;Neurodegenerative Disorders;Neuroimmune;neuroinflammation;Neurologic;Neuronal Injury;Neurons;Neuropathogenesis;neuropathology;neurotoxic;neurotoxicity;new therapeutic target;pathogen;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;placebo controlled study;Play;prevent;Process;Production;protein aggregation;Proteins;Protocols documentation;Retroviridae;Role;Site;small molecule;Syndrome;Therapeutic;therapeutic development;Tissues;trafficking;transmission process;Treatment Protocols;Viral;Viral Proteins;Viral reservoir;Virus;Virus Activation;Virus Diseases;Virus Latency

PROJECT_TITLE: Neuropathogenesis of Retroviral Infections


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Hearing Loss;Neurodegenerative;Neurofibromatosis;Neurosciences;Peripheral Neuropathy;Rare Diseases

PROJECT_TERMS: 22q;Affect;Attention;autosome;Benign;bilateral vestibular Schwannoma;biomarker identification;Central Nervous System;Central Nervous System Neoplasms;Cephalic;Code;cohort;Counseling;Cranial Nerves;Cross-Sectional Studies;Data;deafness;Deglutition;Development;Disease;Disease Progression;Ependymoma;Excision;Exons;Fascicle;Functional disorder;Future;Genes;Genomics;Genotype;Germ Lines;Germ-Line Mutation;Glioma;Goals;Growth;Hearing;hearing impairment;Image;improved;Infratentorial Neoplasms;insertion/deletion mutation;Intervention;Karnofsky Performance Status;Knowledge;Location;longitudinal analysis;Longterm Follow-up;Magnetic Resonance Imaging;Measurement;Measures;Medical;meningioma;Methods;Monitor;Morbidity - disease rate;Mutation;Natural History;Nature;Neoplasms;neoplastic cell;Nerve;nerve injury;Nervous System;Neurilemmoma;neuro-oncology;Neurofibromatosis 2;Neurofibromin 2;Neurologic Deficit;Neuropathy;Numbness;Operative Surgical Procedures;Paralysed;Patient Self-Report;Patients;Pattern;Penetrance;Performance;Perilymph;Peripheral Nerve Schwannoma;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Peripheral Nervous System Neoplasms;Pharmacotherapy;Phenotype;Population;prevent hearing loss;prospective;Proteins;Protocols documentation;Radiation therapy;Reporting;research clinical testing;Resolution;Risk;RNA Splicing;Severities;Severity of illness;Site;Speech;Spinal nerve structure;Structure;Symptoms;Syndrome;Therapeutic;Time;tool;Treatment outcome;trend;tumor;Tumor Biology;Tumor Burden;tumor growth;Tumor Suppressor Genes;Uncertainty;validation studies;Variant;Vestibular Nerve

PROJECT_TITLE: Neurooncology of Benign Central and Peripheral Nervous System Tumors


NIH_SPENDING_CATS: Neurosciences

PI_NAMEs: KHALIQ, ZAYD M (contact)

PROJECT_TERMS: association cortex;Auditory;Auditory area;Axon;Basal Ganglia;Behavior;Behavioral;Biochemical Markers;Brain;Calcium;Calcium Signaling;Categories;Cell Nucleus;Chemosensitization;cholinergic;conditioning;Corpus striatum structure;Cues;Dendrites;Diazepam;Dopamine;dopamine system;dopaminergic neuron;Exhibits;experimental study;Future;GABA-A Receptor;Goals;Heterogeneity;Interneurons;Laser Scanning Microscopy;Learning;Ligands;Light;Measures;Memory;Midbrain structure;Motivation;motor disorder;motor learning;neuronal cell body;Neurons;neurophysiology;neuropsychiatric disorder;Nicotinic Receptors;optogenetics;Parkinson Disease;pars compacta;patch clamp;Pathway interactions;Pattern;Phase;Physiology;Picrotoxin;Play;Presynaptic Terminals;Property;receptor;recruit;Retrieval;Rewards;Role;Shapes;Signal Transduction;Slice;sound;Structure of subthalamic nucleus;Study Section;Substantia nigra structure;Synapses;Tail;Techniques;Testing;Tetanus Toxin;Tissues;Transgenic Animals;two-photon;Work

PROJECT_TITLE: Synaptic integration and intrinsic firing properties of basal ganglia neurons


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

PI_NAMEs: LU, WEI  (contact)

PROJECT_TERMS: Alcohols;Alzheimer's Disease;Amygdaloid structure;Analgesics;Animal Behavior;Animals;Anxiety;autism spectrum disorder;Behavioral;Binding;Binding Proteins;Biochemical;Brain;Canada;Cell Adhesion Molecules;Cell Nucleus;Cells;Chemosensitization;China;Chronic stress;Cognition;Collaborations;college;Complex;Data Reporting;Defect;Development;Diazepam;Disease;Electrophysiology (science);Epilepsy;frontier;Functional disorder;GABA-A Receptor;General Anesthesia;General anesthetic drugs;Genetic;gephyrin;Goals;Health;Hong Kong;Human;hypnotic;in vivo;Inhibitory Synapse;insight;Integral Membrane Protein;interest;Journals;London;Manuscripts;Mediating;Mental Depression;Mental disorders;Molecular;Mus;Mutation;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neural;neural circuit;neuroligin 2;neuromechanism;neuronal circuitry;Neurons;Neurosciences;neurotransmission;novel;Pathogenesis;Pathway interactions;pharmacologic;Population;Psychopharmacology;Publications;Publishing;Regulation;Reporting;Research;Research Project Grants;Role;Science;Signal Pathway;Social Behavior;Spinal cord injury;stem cells;Stress;Synapses;Synaptic plasticity;Synaptic Transmission;synaptogenesis;Technology;trafficking;transmission process;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: The regulation of synaptic transmission and neural circuit function


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Human Genome;Neurosciences

PI_NAMEs: YUAN, QUAN  (contact)

PROJECT_TERMS: aging brain;Animals;Area;Behavioral;behavioral plasticity;Binding Proteins;Biological Process;Brain;Candidate Disease Gene;Cell model;Cells;chemical genetics;Cholinergic Receptors;cholinergic synapse;circadian;Dendrites;Development;Drosophila acetylcholine receptor alpha-subunit;Drosophila genome;Drosophila genus;Ensure;Environment;Exhibits;experience;functional plasticity;Genetic;genetic approach;Genetic study;Goals;Homeostasis;Image;imaging approach;imaging study;in vivo;in vivo evaluation;Insecta;interest;Investigation;Label;Lateral;Learning;Ligand Binding;Lipid Binding;lipid transport;Lipids;Modeling;Molecular;Monitor;Morphogenesis;multiple omics;Nervous System;neural network;Neuroglia;neuronal excitability;Neuronal Plasticity;Neurons;Neuropeptides;neuroregulation;novel;Organism;Output;Oxidation-Reduction;Pathologic;Pathway interactions;Photoreceptors;Physiological;Pigments;postsynaptic;Process;Property;Proteins;Receptor Signaling;Regulation;Research;Resolution;response;Role;Sensory;Synapses;Therapeutic;trafficking;transcriptome;Translating;Visual

PROJECT_TITLE: Experience-dependent regulation of dendrite morphogenesis and plasticity


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: FORREST, LUCY  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;Architecture;ATP Hydrolysis;Back;Behavior;Betaine;Binding;Binding Sites;Biochemical;Biophysics;Carrier Proteins;Cell membrane;Cellular Membrane;Chemistry;Collaborations;computer studies;Coupled;Data;design;Diabetes Mellitus;Drug Interactions;Energy-Generating Resources;Environment;Event;experimental study;Exposure to;flexibility;Human Genome;Integral Membrane Protein;Ions;laboratory experiment;Light;Lipid Bilayers;Lipids;Location;Measurement;Membrane;Membrane Proteins;Membrane Transport Proteins;Mental Depression;Mitochondria;Molecular;Molecular Conformation;molecular dynamics;Movement;Movement Disorders;natural flow;Neurons;Neurotransmitters;novel therapeutics;Nutrient;Organism;Pathway interactions;Pattern;Pharmacological Treatment;Physiological;Play;Process;Protein Conformation;protein protein interaction;Proteins;Publishing;pyruvate carrier;Regulation;response;Role;serotonin transporter;Shapes;Side;Site;small molecule;Specificity;Structure;symporter;Techniques;Transmembrane Transport;Work

PROJECT_TITLE: Computational studies of membrane transport proteins


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PROJECT_TERMS: Amino Acids;autism spectrum disorder;Axon;axon guidance;Binding;Binding Proteins;Biochemistry;Biological;Biology;Brain;Brain-Derived Neurotrophic Factor;candidate identification;CDK5 gene;Cell Adhesion Molecules;Chemosensitization;Collaborations;Compensation;Cues;Cyclic AMP-Dependent Protein Kinases;Data;de novo mutation;Defect;density;Development;Disease;DNA Sequence Alteration;Electrophysiology (science);Embryo;Equilibrium;Etiology;Excitatory Synapse;experimental study;Extracellular Domain;Female;Functional disorder;Gene Family;Genes;Genetic Engineering;Genetic Predisposition to Disease;Growth;Growth Cones;high throughput screening;Human;human induced pluripotent stem cells;Image;in utero;Inhibitory Synapse;insight;Intellectual functioning disability;interest;Investigation;Link;Maintenance;male;Mediating;Mediator;Missense Mutation;Mitogens;Molecular;mouse model;Mutation;National Center for Advancing Translational Sciences;Neurodevelopmental Disorder;neuron development;Neuronal Differentiation;Neurons;NRCAM gene;Pathogenicity;Patients;Phenocopy;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Point Mutation;Post-Translational Protein Processing;postsynaptic;Postsynaptic Membrane;presynaptic;Protein Family;Protein Isoforms;Protein Kinase C;protein protein interaction;Proteins;Publishing;rare variant;Regulation;Reporting;Research Personnel;response;Rodent;Role;Semaphorin-3A;sex;Sex Bias;Signal Transduction;small molecule;Specific qualifier value;Specificity;stable cell line;Surface;Synapses;Synaptic Cleft;Synaptic Transmission;synaptogenesis;trafficking;Variant;Vertebral column;Work;X Chromosome;Y Chromosome

PROJECT_TITLE: Regulation of Neuroligins and Effects on Synapse Number and Function


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences

PROJECT_TERMS: 3-Dimensional;Address;Amino Acid Sequence;Automation;Bioinformatics;biophysical techniques;Cell membrane;Cells;Cellular Membrane;Computing Methodologies;Data;data integration;Data Set;data visualization;database structure;Databases;Deuterium;Development;Electron Spin Resonance Spectroscopy;Elements;Encyclopedias;Evolution;fascinate;FDA approved;Future;genetic makeup;Goals;Human;Hydrogen;Hydrophobicity;improved;Individual;insight;interest;Knowledge;machine learning method;Membrane;Membrane Proteins;Methodology;Methods;Molecular;Molecular Conformation;molecular modeling;movie;National Institute of Neurological Disorders and Stroke;Nature;Organism;Outcome;Pattern;Pharmaceutical Preparations;Positioning Attribute;Procedures;Protein Conformation;protein function;protein structure;protein structure prediction;Proteins;public database;Publishing;Recording of previous events;Resources;Shapes;simulation;Standardization;structural biology;Structure;Techniques;Technology;Update;user-friendly;Water;web server;Work

PROJECT_TITLE: Development and assessment of methods for membrane protein structure prediction


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Epilepsy;Mental Health;Neurodegenerative;Neurosciences

PI_NAMEs: ZAGHLOUL, KAREEM  (contact)

PROJECT_TITLE: Investigating the neural mechanisms of human cognitive function through intracranial recordings


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PROJECT_TERMS: adenoma;Anterior Pituitary Gland;Benign;Cell Cycle;Cell Physiology;Clinical;comparative;Controlled Environment;Corticotropin;Detection;Diagnosis;Disease;disease model;DNA Sequence Alteration;effective therapy;Epigenetic Process;epigenomics;Excision;Functional disorder;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Genomics;Goals;Hormone secretion;Human;Image;improved;improved outcome;In Vitro;induced pluripotent stem cell;Lead;life span;Light;Magnetic Resonance Imaging;Medical;Metabolic;metabolic imaging;Methylation;Modeling;Molecular;Morbidity - disease rate;Mutation;new therapeutic target;novel;Operative Surgical Procedures;Pathway interactions;Patient-Focused Outcomes;Patients;personalized medicine;Physiology;Pituitary Gland;Pituitary Gland Adenoma;Pituitary Neoplasms;Pituitary-dependent Cushing's disease;PMAIP1 gene;preservation;Research;Somatic Mutation;stem cell model;Technology;treatment choice;Treatment Failure;treatment strategy;tumor;tumorigenesis;USP8 gene

PROJECT_TITLE: Improved Diagnosis and Treatment of Cushing's Disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

PI_NAMEs: LEVINE, ARIEL  (contact)

PROJECT_TERMS: Adult;Area;Atlases;Behavior;Behavioral;Brain;brain pathway;brain tract;Cell Physiology;Cell Size;cell type;Cells;Central Nervous System;Cues;Cytoskeleton;Development;Disease;dorsal horn;Feedback;Foundations;Genes;Genetic;Genetic Predisposition to Disease;Goals;Human;improved;Knowledge;Link;Mediating;Motor;motor behavior;motor control;motor learning;Motor Neurons;mouse genetics;Movement;Mus;neural;Neurons;Pathway interactions;Patients;Population;Posterior Horn Cells;programs;Recovery;recruit;Regulation;Sensorimotor functions;Sensory;single cell sequencing;single nucleus RNA-sequencing;Spinal;Spinal Cord;Spinal cord injury;Spinal cord posterior horn;Stroke;tool;Viral;Work

PROJECT_TITLE: Mechanisms of Motor Control in the Spinal Cord


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Physical Activity;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

PROJECT_TERMS: 18 year old;2019-nCoV;adjudication;Admission activity;Age;aged;Area;Back;Bioenergetics;Biological;Brain;Brain region;Catechols;Cerebrospinal Fluid;Chronic;Chronic Fatigue Syndrome;Clinical;clinical center;Clinical Trials;Cognitive;Communication;Communities;COVID-19 patient;Cross-Sectional Studies;design;Diagnosis;Disabling;Electrophysiology (science);Enrollment;Evaluation;Exercise;Exercise Test;Exertion;experience;Fatigue;Female;Focus Groups;Functional disorder;Functional Magnetic Resonance Imaging;Gene Expression Profile;Generations;Guidelines;healthy volunteer;Hour;Immune;immune function;Immune system;immunomodulatory therapies;inclusion criteria;Infection;Inflammatory;Inpatients;Internet;Lyme Disease;Malaise;Measurement;Measures;meetings;Memory B-Lymphocyte;Metabolic;Metabolic Pathway;microbiome;mild cognitive impairment;Muscle;Nature;Neurocognition;neuroimaging;neurologic sequelae of COVID-19;Outcome Measure;Participant;participant enrollment;Pathway interactions;Patients;Pattern;Peripheral Blood Mononuclear Cell;Persons;Phenotype;physical conditioning;Physicians;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;preference;Procedures;Process;Protocols documentation;Publishing;Questionnaires;Recording of previous events;Reporting;Research;Sampling;screening;sex;Signal Transduction;Specimen;Stress;study population;Surveys;Symptoms;Syndrome;Techniques;Telephone Interviews;Time;Transcranial magnetic stimulation;United States National Institutes of Health;Viral;Visit;volunteer

PROJECT_TITLE: Post-Viral Syndromes