ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health;Women's Health Research

ORG_CITY: WORCESTER

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Depression and poverty are linked together in an intractable syndemic affectig millions of people around the world. Poverty is a major cause of depression, while depression significantly reduces economic productivity. Integrated intervention approaches that seek to interrupt the cycle of poverty and depression have not been tested. This application describes ASHA: an integrated intervention that combines depression treatment with economic strengthening for depressed, low income women in rural Bangladesh. If the research is successful, we will work with government and NGO partners to initiate new collaborations between mental health researcher’s/policy makers and development groups seeking to increase economic productivity and wellbeing in Bangladesh and other countries of the global south.

PI_NAMEs: KARASZ, ALISON  (contact);TOFAIL, FAHMIDA

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Address;Advocate;Agriculture;arm;Asia;Bangladesh;career development;Caring;Child;Clinical;Cluster randomized trial;Collaborations;comparison control;contextual factors;cost;Country;Decision Making;Depressed mood;depressive symptoms;design;Development;diarrheal disease;disability;Disease remission;doctoral student;Dose;Economic Development;economic outcome;Economics;Effectiveness;empowerment;Evaluation;evidence base;experience;Family;Fellowship;fighting;Generations;Government;Government Agencies;graduate student;hands on research;Health;Health Care Costs;Health Personnel;High Prevalence;implementation outcomes;implementation process;implementation research;implementation study;improved;Individual;insight;International;international center;Interruption;Intervention;Intervention Studies;Interview;Investigation;Link;low and middle-income countries;Low income;Low Income Population;Manuals;Massachusetts;Mediating;Mediator;medical schools;men;Mental Depression;Mental Health;Methods;Modeling;novel;Outcome;pandemic disease;Participant;Pathway interactions;Patients;Perception;Personal Satisfaction;Persons;Pilot Projects;Play;Policies;Policy Developments;policy implication;Policy Maker;Poverty;poverty alleviation;process evaluation;Productivity;programs;psychosocial wellbeing;Randomized;recruit;Relapse;Research;Research Personnel;Research Training;Resource-limited setting;Role;Rural;Scientist;skills;Social support;Structure;syndemic;Testing;treatment arm;treatment effect;treatment trial;Universities;university student;uptake;Woman;Work

PROJECT_TITLE: ASHA Bangladesh--An Integrated Intervention to Address Depression in Low Income Rural Women


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: ARLINGTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

ORG_STATE: TX

PHR: Project Narrative Our studies of the elimination of morphologically complex cells will provide important fundamental insights on programmed cell death and clearance, which are essential facets of proper development and homeostasis. These studies are relevant to public health in several respects: our findings may help devise targeted therapies against both tumor formation and immune dysfunction as well as in understanding brain development, injury and disease.

PI_NAMEs: GHOSE, PIYA  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Animals;Apoptosis;Architecture;Autoimmune Diseases;Biological;Brain;Caenorhabditis elegans;cancer therapy;Cell Death;Cell Physiology;Cells;Cellular biology;Cessation of life;Complex;Defect;Development;developmental disease;Disease;Embryonic Development;Excision;experimental study;Genes;Genetic;genetic analysis;Genetic study;Health;Homeostasis;Immune System Diseases;in vivo;Inflammation;Injury;insight;Interphase Cell;Lead;Link;Malignant Neoplasms;Mitochondria;Modeling;Morphology;Mutation;Nerve Degeneration;Neurons;novel;programs;Public Health;Regulation;Regulator Genes;Resistance;Role;sex;targeted treatment;trafficking;tumor

PROJECT_TITLE: In Vivo Genetic Analysis of Compartmentalized Cell Elimination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PI_NAMEs: AHSAN, HABIBUL  (contact);ASCHEBROOK-KILFOY, BRISEIS A;DAVIGLUS, MARTHA L;GREENLAND, PHILIP ;HO, JOYCE ;PIRZADA, AMBER ;ROBERSON, TONYA ;SANDERS, ALAN R;SHAH, RAJ C

PROGRAM_OFFICER_NAME: LOPEZ-CLASS, MARIA

PROJECT_TERMS: Acceleration;Accounting;Adult;Age;All of Us Research Program;Amber;Area;Arthritis;Automobile Driving;Award;Awareness;Biomedical Research;career;Catchment Area;Cessation of life;Chicago;Childhood;Church;Clinical;Clinical Informatics;clinical phenotype;clinical research site;cohort;Collaborations;Collection;Communities;community empowerment;Community Health;community organizations;community partnership;community-centered;Complex;Computers;Coronary heart disease;COVID-19 pandemic;cultural competence;Data;data exchange;data quality;Dedications;Dementia;demographics;digital;digital technology;disability;Disease;disparity reduction;Education;Electronic Health Record;Electronic Mail;Enrollment;Ensure;Environmental Exposure;epidemiology study;Equity;equity, diversity, and inclusion;Ethnic Origin;Ethnic Population;Evaluation;Event;expectation;experience;Family;flexibility;follow-up;Friends;Funding;Genetic;Genomics;Geography;Goals;Graduate Education;Greenland;Hand;Health;Health care facility;health disparity;health equity;Health Personnel;Health Sciences;Health Service Area;Health system;Health Technology;Healthcare;Healthcare Systems;Hour;Human;human disease;Illinois;implementation strategy;improved;Income;Indiana;Infrastructure;innovation;insight;Institution;interest;Internet;interoperability;Investments;Knowledge;Leadership;life span;Link;Malignant Neoplasms;member;Methods;metropolitan;mHealth;Minority Groups;Minority-Serving Institution;Modality;Municipalities;Observational epidemiology;Operations Research;outreach;Participant;patient population;Patients;Pediatrics;Performance;Persons;Physicians;Play;podcast;Population;population based;population health;Population Heterogeneity;Positioning Attribute;Precision Health;precision medicine;Prevention;programs;Protocols documentation;Provider;Race;racial population;recruit;Research;Research Activity;Research Personnel;Residential Facilities;resilience research;Resources;response;Role;Rural;Rural Population;Saliva;Schools;Science;Scientist;Services;Site;skills;Source;Stroke;Structure;Students;suburb;success;synergism;System;Target Populations;Telephone;Text Messaging;Training;Training Programs;trend;undergraduate education;United States;United States National Institutes of Health;Universities;Voice;web site;Work

PROJECT_TITLE: The Illinois Precision Medicine Consortium (IPMC) All of Us Research Program Site


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Hematology;Kidney Disease

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative The Cleveland Kidney, Urology and Hematology Research (KUHR) Training Network has designed a one and a half daylong meeting to train the next generation of KUHR professionals. The proposed KUHR meeting seeks to support the development of these emerging investigator leaders who will gain the expertise to provide innovative solutions to the fields of Kidney, Urology and Hematology. To reach the goal successfully, additional funds to support trainee travel from all of the active U2C/TL 1 sites would be extremely beneficial.

PI_NAMEs: BORON, WALTER F;SEDOR, JOHN R. (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TITLE: Cleveland Kidney, Urology and Hematology Training Network


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Treatment-resistant depression (TRD) is the most severe form of major depressive disorder (MDD), and responsible for a disproportionate portion of its morbidity. We will use a novel approach to resting state fMRI, known as precision functional mapping (PFM), to develop patient-specific biomarkers of TRD and the depressed state. Better understanding of trait and state features of depression may lead to improved diagnosis and treatment of this disabling condition.

PI_NAMEs: LAUMANN, TIMOTHY OTTO (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Anterior;Award;Behavioral;Biological Markers;biomarker identification;Brain;Brain imaging;Brain Pathology;career;career development;Categories;Characteristics;Clinical;cognitive neuroscience;cohort;comorbidity;cost;Coupled;Data;data acquisition;Data Set;Depressed mood;depressed patient;depressive symptoms;design;Diagnosis;Dimensions;disability;Disabling condition;Disease;Disease remission;Dose;Ecological momentary assessment;Electroconvulsive Therapy;Evaluation;Exhibits;experience;Failure;feasibility testing;Functional Magnetic Resonance Imaging;Goals;Grant;Heterogeneity;high risk;Hippocampus;human subject;Image;improved;Individual;Intervention;Learning;Limb structure;Major Depressive Disorder;Maps;Measurement;Measures;Mental Depression;Mentorship;Methods;Modality;Moods;Morbidity - disease rate;mortality;neuroimaging;neuroimaging marker;neuropsychiatric disorder;novel;novel strategies;Pathologic;Pathology;Pathway interactions;patient response;Patients;Pattern;Phase;Phenotype;Physicians;Population;Positioning Attribute;Principal Investigator;programs;Psychopathology;Reproducibility;Research;Research Design;Residencies;Resistance;Rest;Scientist;Severities;skills;specific biomarkers;standard care;Structure;suicidal risk;Symptom Burden;Symptoms;Techniques;Time;tool;Training;trait;Treatment Cost;treatment duration;treatment response;treatment-resistant depression;Virulent

PROJECT_TITLE: Precision Functional Mapping in Treatment-Resistant Depression

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: GENETICS

PHR: Project Narrative Mutations of the mitochondrial DNA-encoded ATPase 6 (MTATP6) gene lead to impaired mitochondrial ATP synthesis, which results in a variety of neurological mitochondrial diseases. Allotopic expression of MTATP6 is a plausible gene therapy approach for restoring mitochondrial dysfunction caused by MTATP6 mutations, while to date it has only been tested in vitro due to the lack of an animal model. The proposed study aims to generate the first MTATP6 targeting mouse model using a novel base editing technology, and develop an adeno- associated virus (AAV)-based gene therapy strategy for MTATP6 patients.

PI_NAMEs: LING, QINGLAN  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;adeno-associated viral vector;adenovirus mediated delivery;Animal Model;ATP phosphohydrolase;ATP Synthesis Pathway;base editing;base editor;Behavioral;Biochemical;Biology;Brain;career;career development;Cell Culture Techniques;cell growth;Cell Line;Cell Nucleus;Cell Physiology;Central Nervous System;Clinical Trials;Code;Codon Nucleotides;Complement;complex IV;Cre driver;Cre-LoxP;CRISPR/Cas technology;Cytoplasm;Dependovirus;Development;Disease;DNA;DNA Sequence;Dose;early onset;efficacy evaluation;Exhibits;Faculty;Fibroblasts;Foundations;Functional disorder;Future;gene editing technology;gene replacement therapy;gene therapy;Genes;Heart;Hereditary Disease;heteroplasmy;Human;Hybrids;Impairment;In Vitro;in vitro testing;in vivo;Inherited;Institution;Knowledge;Laboratories;Lead;Leigh Disease;Liver;Long-Term Effects;Mentors;Missense Mutation;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;mitochondrial gene replacement;Mitochondrial Proton-Translocating ATPases;mouse genetics;mouse genome;mouse model;Mus;mutant;mutant mouse model;Mutation;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;Neuropharmacology;new technology;novel;Nuclear;oligomycin sensitivity-conferring protein;Pathology;Patients;Phase;Phenotype;Positioning Attribute;Proteins;Recombinant adeno-associated virus (rAAV);Research;Resources;Respiratory physiology;Route;Safety;Scheme;Skeletal Muscle;skills;Specificity;Technology;tenure track;Terminator Codon;Testing;Therapeutic;Tissues;tool;Training;Training and Education;training opportunity;Transduction Gene;Transgenic Mice;translational study;Treatment Efficacy;Variant;vector;vector biodistribution;Wild Type Mouse

PROJECT_TITLE: First murine animal model and adeno-associated virus (AAV)-based gene therapy for MTATP6 mitochondrial diseases


NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: CHAPEL HILL

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Family violence imposes substantial and long-lasting burdens on children, particularly those in heavily policed and incarcerated communities. But little is known about how objective and subjective experiences of institutional contact in such communities may affect family violence incidence, disclosure, help-seeking, or consequences. The proposed project will advance the study of children’s exposure to family violence in the contemporary United States by collecting primary qualitative and survey data and applying inductive and latent variable methods for formative analysis. psychometric validation, and hypothesis testing.

PI_NAMEs: MCKAY, TASSELI  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Adolescent;Affect;American;analytical method;authority;career;Chicago;Child;Child Abuse and Neglect;Child Development;Child Health;Child Welfare;Childhood;cognitive interview;cohort;Cohort Studies;Communities;Data;Dedications;Development;Dimensions;Disclosure;Environment;Etiology;Event;experience;Exposure to;Faculty;Family;Family member;Family Process;Family Study;Family Violence;Feedback;Foundations;Goals;Growth;Health;health care service;health science research;help-seeking behavior;Human Development;Imprisonment;Incidence;Individual;innovation;insight;Institution;Intervention;Interview;Law Enforcement;Legal system;Link;Longitudinal Surveys;maltreatment;Measurement;Measures;Mentors;Mentorship;Methodology;Methods;model development;Modeling;National Institute of Child Health and Human Development;Neighborhoods;novel;Outcome;Parents;Participant;Pathway interactions;Personal Satisfaction;Persons;Phase;Police;Positioning Attribute;Poverty;Principal Investigator;probation;Psychometrics;public health intervention;Public Policy;Punishment;Reaction;Reporting;Research;Review Literature;Risk;Role;Scientist;secondary analysis;Secure;service utilization;Shapes;skills;social determinants;social service provider;sound;Structural Racism;Support System;Surveys;tenure track;Testing;Time;tool;Training;trait;transition to adulthood;United States;Validation;Violence;violence exposure;vulnerable community;Work;Youth

PROJECT_TITLE: Institutional Contact and Family Violence in an Era of Mass Incarceration


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PI_NAMEs: SWERDLOW, RUSSELL H. (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TITLE: Core A: Administrative Core


PI_NAMEs: BURNS, JEFFREY MURRAY (contact)

PROJECT_TITLE: Core B: Clinical Core


PI_NAMEs: MAHNKEN, JONATHAN D (contact)

PROJECT_TITLE: Core C: Data Management and Statistical Core


PI_NAMEs: HAERI, MOHAMMAD  (contact)

PROJECT_TITLE: Core D: Neuropathology Core


PI_NAMEs: VIDONI, ERIC DENNIS (contact)

PROJECT_TITLE: Core E: Outreach, Recruitment and Engagement Core


PROJECT_TITLE: Core F: Biomarker Core


PI_NAMEs: HONEA, ROBYN A (contact)

PROJECT_TITLE: Core H: Neuroimaging Core


PI_NAMEs: TOWNLEY, RYAN ARMSTRONG (contact)

PROJECT_TITLE: Core G: Research Education Component


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: The precision medicine research made possible by the All of Us Research Program holds the potential to speed up discoveries that could help alleviate the crushing burden of chronic diseases and improve health outcomes for all individuals—regardless of geography or background.

PI_NAMEs: COMELLAS, ALEJANDRO PIERRE;DESOUZA, CYRUS V;GREINER, K ALLEN;KOOPMAN, RICHELLE J;OJO, AKINLOLU OLUSEUN (contact);PETERMAN, TAMMY ;SALATHE, MATTHIAS A;STITES, STEVEN W

PROGRAM_OFFICER_NAME: RAHMAN, MD MIZANUR

PROJECT_TERMS: Academic Medical Centers;Academy;Acute Renal Failure with Renal Papillary Necrosis;Address;Advisory Committees;Age;All of Us Research Program;Alzheimer's Disease;Ancillary Study;Asthma;biobank;Biomedical Research;Black Populations;Cardiovascular Diseases;Cessation of life;Clinics and Hospitals;cohort;Collaborations;Communities;community collaboration;Community Healthcare;community organizations;community partners;cost;County;COVID-19;COVID-19 disparity;COVID-19 impact;COVID-19 morbidity;COVID-19 mortality;COVID-19 pandemic;COVID-19 prevention;Data;data exchange;data warehouse;Death Rate;design;Disadvantaged;Disease;disorder prevention;Economics;Electronic Health Record;Enrollment;Ensure;ethnic disparity;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;experience;Genetic;geographic disparity;Geography;Goals;Health;health difference;health disparity;Health Personnel;Health system;hospital organization;Hospitalization;improved;Individual;Infrastructure;innovation;institutional capacity;Iowa;Kansas;lifestyle factors;Link;Longevity;Malignant Neoplasms;Maternal and Child Health;Measures;Medical center;Medicine;Mental Health;Minority Groups;Mission;Missouri;Myocarditis;Nebraska;Not Hispanic or Latino;Occupational;Outcome;pandemic disease;Participant;participant enrollment;participant retention;patient engagement;Physiological;Policies;Population;precision medicine;Precision Medicine Initiative;Predisposition;prevention clinical trial;Prevention strategy;Procedures;Process;programs;Protocols documentation;Public Participation;quality assurance;Quality Control;Quality of Care;Quality of life;Race;racial disparity;racial minority;racial minority population;racial population;Recording of previous events;Reduce health disparities;Reporting;Research;Research Project Grants;Research Proposals;resilience;Resources;retention rate;Rural;Rural Community;rural dwellers;Rural Population;Secure;social;Standardization;stem;Substance abuse problem;targeted treatment;Technical Expertise;Therapeutic Clinical Trial;treatment response;United States;United States Food and Drug Administration;United States National Institutes of Health;Universities;Wit;Work;working group;World Health Organization

PROJECT_TITLE: All of Us Research Program Heartland Consortium (AoURP-HC)


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Not applicable.

PI_NAMEs: SANES, DAN HARVEY (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Auditory area;social learning

PROJECT_TITLE: Social learning enhances auditory cortex sensitivity and task acquisition


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Malaria, caused by Plasmodium species, is an unresolved global health burden without an effective vaccine. Development of potent and translatable vaccines against malaria has been hampered by our incomplete understanding of the mechanisms by which the immune system can be trained to control Plasmodium infections. The goal of this research is to dissect mechanisms of CD8 T cell-mediated protection against liver-stage malaria.

PI_NAMEs: HARTY, JOHN T (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Address;Africa South of the Sahara;Anti-malarials;Antibodies;Antigen Presentation;Attenuated;Beds;Binding;Bite;Blood;CD8-Positive T-Lymphocytes;CD8B1 gene;Child;Clinical;combat;Culicidae;Data;Dermal;Development;Disease;Drug resistance;Epitopes;Erythrocytes;Frequencies;Generations;global health;Goals;Hepatocyte;Human;Immune system;Immunity;Immunization;Immunize;Immunology;improved;Incidence;Infection;Injections;Insecticides;Knowledge;Laboratories;Liver;Malaria;Malaria Vaccines;Mediating;Membrane;Memory;Modeling;Mus;novel;parasite invasion;Parasite resistance;Parasites;Pharmacotherapy;Plasmodium;Play;Population;prevent;Property;Radiation;recruit;Research;response;Rodent Model;Role;Route;Severities;Skin;Sporozoite vaccine;Sporozoites;T-Lymphocyte;Time;Tissues;Training;transmission process;United States National Institutes of Health;Vaccination;vaccination strategy;vaccine development;vaccine-induced immunity;Vaccines

PROJECT_TITLE: Immunity to Liver-stage malaria

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE The risk and severity of disease associated with environmental and endogenous exposures can vary greatly depending on the unique genetic makeup of an individual. The large number of possible genetic and environment combinations limits our ability to identify these interactions despite their potential to inform strategies for disease prevention and therapeutic intervention. I propose to develop high-throughput methods that overlay genetic and environmental perturbations to systematically identify these gene-by-environment interactions as well as pinpoint the specific cell types responsible for the response.

PI_NAMEs: MCFALINE-FIGUEROA, JOSE LUIS (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Alzheimer's Disease;cell type;Cells;clinically actionable;Clustered Regularly Interspaced Short Palindromic Repeats;Couples;Disease;disorder prevention;Environment;Epilepsy;Exposure to;flexibility;gene environment interaction;Genes;Genetic;genetic makeup;Genetic Screening;Genetic Transcription;Goals;In Situ;In Vitro;in vivo;Individual;individual response;Malignant neoplasm of brain;Methods;Molecular;Mus;Mutate;Mutation;Neurobiology;Neurons;Nuclear;Oxidative Stress;Peptides;preventive intervention;programs;receptor expression;Research;Resolution;response;Risk;Sampling;Severity of illness;single cell genomics;single-cell RNA sequencing;System;Technology;Therapeutic Intervention;tool;tumor;Virus Receptors

PROJECT_TITLE: Defining gene-by-environment interactions using multiplex single-cell genomics


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Pediatric

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: There is a great shortage in the United States of qualified pediatrician-scientists, including pediatric endocrinologists, with a growing unmet need for better treatments of pediatric endocrine diseases like obesity and diabetes. These diseases pose a great threat to the future health of our nation's children (illustrated most recently by the increased risk conferred by obesity in the recent COVID-19 pandemic), and are a major source of health disparities. We hope that our training program, with strong mentors and educational opportunities, will address this need by guiding and supporting the early careers of a highly motivated and diverse group of pediatric endocrinology trainees, and inspiring them to become leaders in academic pediatric endocrinology and biomedical research.

PI_NAMEs: HIRSCHHORN, JOEL N (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: RESEARCH IN DEVELOPMENTAL ENDOCRINOLOGY AND METABOLISM

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW HAVEN

ORG_DEPT: SURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative To advance healthcare quality improvement and clinical research by integrating clinical data across institutions in a privacy-preserving manner, we will develop a decentralized framework to compute with comprehensive clinical variables and with numerous records, to discover and alleviate data manipulation during the learning process, and to conduct controlled experiments and design/test a web portal with physician-researchers, on real cross-institutional COVID-19 data. This project is innovative as it proposes a new integration methodology for vertical/horizontal modeling, a novel data manipulation resisting methods, and a hardened prototype for a practical blockchain application. We expect powerful and sustainable impact for care providers, clinical researchers, and patients, and can eventually accelerate the development of methods/technologies to increase willingness of institutions to participate in such a collaboration for improving the effectiveness of healthcare.

PI_NAMEs: KUO, TSUNG-TING  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Acceleration;Address;Artificial Intelligence;blockchain;California;care providers;Clinical;Clinical Data;Clinical Research;Collaborations;COVID-19;Data;Data Set;data sharing;data warehouse;Decentralization;design;Discrimination;Disease;Effectiveness;Electronic Health Record;Ensure;experimental study;Extravasation;Failure;Health;health care quality;Health Personnel;Health protection;Health Status;Healthcare;Hospitals;improved;innovation;Institution;Intuition;Knowledge;Laboratories;Laboratory Research;Learning;learning strategy;Machine Learning;Medical center;method development;Methodology;Methods;Mission;model generalizability;Modeling;Modernization;novel;Outcome;Patients;peer;Performance;Pharmaceutical Preparations;Physicians;Policies;Predictive Analytics;predictive modeling;Primary Care Physician;Privacy;privacy preservation;privacy protection;Process;Protocols documentation;prototype;Records;Regulation;Research Personnel;Risk;Security;Site;Societies;System;Technology;Testing;Training;trustworthiness;United States National Institutes of Health;Universities;usability;Validation;web portal;willingness;Work

PROJECT_TITLE: SOCAL: Privacy-protecting Sharing Of Clinical Data Across Laboratories

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ORG_CITY: WASHINGTON

ORG_NAME: ASSOCIATION OF AMERICAN MEDICAL COLLEGES

ORG_STATE: DC

PHR: Project Narrative: The Association of American Medical Colleges (AAMC) welcomes the opportunity to continue partnering with the National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) to advance our shared goal of enhancing the diversity of the biomedical research workforce. Through this supplement funding request, the AAMC will be able to continue to develop and deliver a multichannel educational program for cohorts of NIH- awarded K99/R00 scholars from diverse backgrounds, for example from groups underrepresented in research, that provides a full suite of career development tools and supports as they transition from postdoctoral appointments into academic research faculty positions. Receiving supplemental funds will allow the AAMC to proceed with richly and robustly engaging the scholars in a curriculum throughout all award years that includes virtual skills-building workshop and in-person networking and learning event participation, engagement activities with their local institutional and AAMC-identified mentors, and leadership and professional development conference attendance with field experts and peers nationwide.

PI_NAMEs: YELLIN, JODI  (contact)

PROGRAM_OFFICER_NAME: GIBBS, KENNETH D

PROJECT_TERMS: Advisory Committees;American;Appointment;Association of American Medical Colleges;Award;Biomedical Research;career development;cohort;Committee Members;design;Development;Discipline;Dissemination and Implementation;Doctor of Philosophy;Education;Educational Curriculum;Educational workshop;Environment;equity, diversity, and inclusion;Evaluation;Event;experience;Faculty;Funding;Goals;Graduate Degree;Hearing;improved;Institution;Leadership;Learning;medical schools;medical specialties;Medicine;member;Mentors;Mentorship;National Institute of General Medical Sciences;Participant;peer;peer coaching;Persons;Positioning Attribute;Postdoctoral Fellow;Program Development;programs;Research;research faculty;Resources;Science;skills;success;symposium;Teaching Hospitals;tool development;Underrepresented Populations;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: AAMC Career Development Program for MOSAIC Scholars


NIH_SPENDING_CATS: Cancer

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative The quickening pace of scientific discovery demands a new generation of physician-scientists who can understand the languages that are spoken both in the research setting and at the bedside. Our plan is to provide rigorous scientific and clinical training in a safe and inclusive environment to train MD-PhD Physician-Scientists. Using this knowledge, these individuals will be ideally positioned to make significant contributions to and improvements in human health, and thereby become the next generation of leaders in biomedical science.

PI_NAMEs: DARVILLE, TONI ;DESHMUKH, MOHANISH P (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: UNC Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PI_NAMEs: ORTIZ, JUSTIN  (contact)

PROJECT_TERMS: Area;Biological;Biological Products;Bioterrorism;Clinical;Communicable Diseases;Contracts;Development;Educational workshop;efficacy testing;Emerging Communicable Diseases;Evaluation;evaluation/testing;Feasibility Studies;immunogenicity;Immunology procedure;Influenza;Influenza A Virus, H1N1 Subtype;influenza virus vaccine;Investigational New Drug Application;Licensing;Natural History;novel vaccines;Office of Administrative Management;product development;protocol development;Qualifying;Reporting;Safety;Sampling;Services;Site Visit;Testing;testing services;Toxicology;Training;vaccine candidate;vaccine development;Vaccines;Validation

PROJECT_TITLE: Task B1C1: Vaccine and Treatment Evaluation Units (VTEU) Protocol Development and Implementation Natural History Challenge Study for Influenza


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Obesity;Prevention;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PI_NAMEs: TUROK, DAVID  (contact)

PROJECT_TERMS: Basic Science;Chemicals;Clinical Research;clinical research site;clinical trial phase II/III/IV;Clinical Trials;Clinical Trials Network;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Contracts;Development;Female Contraceptive Agents;Formulation;Goals;Grant;Health education;Lead;Male Contraceptive Agents;Methods;Mission;National Institute of Child Health and Human Development;Obesity;Phase;Population Research;pre-clinical;Protocols documentation;Reproductive Health;Risk Reduction;Site;synthetic peptide;Testing;unintended pregnancy;United States National Institutes of Health;venous thromboembolism;welfare;Woman

PROJECT_TITLE: CCTN - CONTRACEPTIVE CLINICAL TRIALS NETWORK - SITES FOR FEMALE CONTRACEPTIVE STUDIES


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Services;Prevention;Women's Health Research

PROJECT_TERMS: Attitude;CCL20 gene;Chlamydia;Clinical;Clinical Practice Guideline;Contraceptive History;Contraceptive methods;Contractor;Contracts;Copper;Copper Intrauterine Devices;Data;Data Analyses;demographics;Development;Devices;Dose;Effectiveness;Eligibility Determination;Enrollment;Ethinyl Estradiol;factor V Leiden;follow-up;Frequencies;Future;Gonorrhea;Good Clinical Practice;Guidelines;Gynecologic;Health;Hemorrhage;hormonal contraception;Hormones;Implant;Incidence;Informed Consent;Instruction;International;Medical;Methods;Monitor;Muscle Cramp;National Institute of Child Health and Human Development;Obesity;Pain;Pap smear;Pattern;Pharmaceutical Preparations;Phase;Pregnancy;Pregnancy Tests;Pregnant Women;Preparation;Procedures;Property;protocol development;Protocols documentation;Randomized;Recording of previous events;Records;recruit;Regulation;Reproductive History;research clinical testing;reversible contraceptive;Risk;Sampling;screening;Specific qualifier value;standard of care;symposium;treatment arm;trial design;ultrasound;Urine;Vaginal Ring;Visit;Woman;Writing;xenoestrogen

PROJECT_TITLE: CCTN - CLINICAL EVALUATION OF LONG-ACTING REVERSIBLE CONTRACEPTIVES


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Patient Safety

ORG_CITY: BETHESDA

ORG_NAME: TECHNICAL RESOURCES INTERNATIONAL, INC.

PI_NAMEs: MILLER, LAUREN  (contact)

PROJECT_TERMS: Adverse event;Agreement;Antineoplastic Agents;Biological Markers;Cancer Therapy Evaluation Program;Clinical Trials;Contracts;Development;drug development;Infrastructure;Investigational Drugs;Monitor;Pharmacologic Substance;Preparation;Regulatory Affairs;Reporting;Safety;Services

PROJECT_TITLE: IPP - DRUG DEVELOPMENT SUPPORT FOR CTEP


NIH_SPENDING_CATS: Complementary and Integrative Health

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

PI_NAMEs: HENNESSEY, ROSLYN  (contact)

PROJECT_TERMS: Clinical Research;clinical research site;Clinical Trials;Contractor;Contracts;Extramural Activities;Funding;Integrative Medicine;Monitor;National Center for Complementary and Integrative Health;quality assurance;Services

PROJECT_TITLE: THE CONTRACTOR SHALL PROVIDE COMPREHENSIVE CLINICAL SITE AND STUDY MONITORING SERVICES FOR THE NCCIH-FUNDED (PRIMARY OR SECONDARY) EXTRAMURAL CLINICAL


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: The VA HSR&D Center for the Study of Healthcare Innovation, Implementation & Policy (CSHIIP) has had a fundamental role in the ongoing transformation of VA health care, through critical examination of multilevel determinants of variations in VA care, development and testing of innovative healthcare delivery models that improve the effectiveness and value of VA care, and impact on VA practice and policy through implementation and spread of evidence-based practice. Our work is anchored in a longstanding history of high-impact research through career development, support, and engagement of a multidisciplinary cadre of investigators, leveraging extensive partnerships that have infused our mission, vision, and values with a deep understanding of VA priorities. These partnerships and priorities have guided our strategic planning, enabling us to build a portfolio of highly responsive research in key focused (primary care, women’s health, high-risk/high-need groups) and emerging areas (complementary/integrative health, specialty care, and emergency management).

PI_NAMEs: YANO, ELIZABETH M (contact)

PROJECT_TERMS: Academy;Acceleration;acute care;Adoption;Affect;Area;care coordination;care delivery;career development;Caring;Collaborations;Communication;Complementary Health;Comprehensive Health Care;Development;Disasters;Discipline of Nursing;Dissemination and Implementation;Doctor of Philosophy;Effectiveness;Emergency Situation;Employee;Employee Engagement;Evaluation;evidence base;Evidence based practice;experience;Funding;Gender;Goals;harassment;Health;Health system;Healthcare;high risk;Home;Homelessness;Homogeneously Staining Region;implementation science;improved;innovation;Integrative Medicine;Intervention;Leadership;Los Angeles;Medical;Medical center;medical schools;medical specialties;Medicine;Mentors;Methodology;Methods;Mission;Modeling;multidisciplinary;Neighborhoods;novel;older adult;operation;Outcome;Paper;Patients;Policies;Primary Care;Provider;provider behavior;Public Health;Publishing;Quality of Care;Readiness;Recording of previous events;recruit;Research;Research Personnel;resilience;Role;Safety;scale up;Scientific Advances and Accomplishments;Service delivery model;Services;severe mental illness;Site;Strategic Planning;substance use;System;Testing;tool;Training;United States Agency for Healthcare Research and Quality;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Variant;Veterans;Vision;whole health;Woman;Women's Health;Women's Health Services;Work;Workplace

STUDY_SECTION_NAME: HCN1 COIN REVIEW[HCN1]


ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: The Center for Mental Healthcare & Outcomes Research (CeMHOR) is an HSR&D Center of Innovation whose mission is to optimize health and well-being of Veterans through innovative research to improve access to and engagement in evidence-based care for mental health and substance use disorders and prevent suicide. CeMHOR accomplishes its mission by partnering directly with Veterans, clinical leaders, and front-line providers to develop feasible and effective interventions to address top VA and national priorities. CeMHOR expertise in implementation science leads to widespread uptake of these interventions. CeMHOR investigators are also experts in rural health and community engagement. CeMHOR research will apply this expertise to include Veterans who are not receiving VA care, as well as those who use VA services but do not fully engage in needed care. In addition to two focus areas, mental health care access/engagement and suicide prevention, investigators conduct research to address opioid misuse and abuse and advance implementation science.

PI_NAMEs: OWEN, RICHARD R. (contact)

PROJECT_TERMS: Address;Ambulatory Care Facilities;American;Area;Arkansas;Awareness;behavioral health;career development;Caring;clay;Clergy;Clinical;Collaborations;Communities;community college;community engagement;Community Outreach;community setting;Demographer;design;Development;effective intervention;Effectiveness;Epidemiologist;Evaluation;evidence base;Federally Qualified Health Center;gaps in access;Goals;Health;health care availability;Health Services;Health Services Research;Healthcare Systems;implementation intervention;implementation science;Improve Access;improved;innovation;Intervention;Knowledge;Location;Managed Care;Medical;Mental disorders;Mental Health;mental health center;Mental Health Services;Mentors;Methods;Mind;Mission;Modeling;opioid abuse;opioid misuse;opioid use disorder;Outcomes Research;peer support;Personal Satisfaction;Pharmacists;Prevention;Prevention strategy;Primary Care;Professional counselor;programs;Provider;Psychiatrist;Psychologist;Research;Research Personnel;Resources;Risk;Rural;rural area;Rural Community;Rural Health;Science;Services;Social Workers;sociologist;Substance Use Disorder;Suicide prevention;Testing;Training;Translating;Universities;uptake;Veterans;virtual healthcare;Work


ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: The Center for Healthcare Organization and Implementation Research has a mission to conduct organizationally-partnered, and Veteran-partnered research in order to develop, implement, and evaluate evidence-based and innovative practices that improve Veterans Health Administration (VA) healthcare. Our priority goals are: (1) to advance the field of HSR by sustaining, developing, and growing our existing, scientific focus areas, and growing our evolving and emerging scientific areas; (2) to enrich VA's cadre of world-class HSR investigators, by supporting training and education across the career spectrum; and (3) to grow and support innovation in order to maintain VA at the cutting edge of HSR and adapt to meet VA's ever- changing needs.

PI_NAMEs: BOKHOUR, BARBARA G.;GIFFORD, ALLEN L (contact)

PROJECT_TERMS: Address;Adherence;Adverse event;Area;Behavioral;Boston;care coordination;care systems;career;career development;Caring;Collaborations;Communication;community living;connected care;Decision Making;Development;Diffusion of Innovation;Educational process of instructing;Elderly;Elements;Environment;evidence base;Face;Future;Geriatrics;Germination;Goals;health care service organization;Health Service Area;Health Services Administration;Health Services Research;Healthcare;Homelessness;implementation research;improved;Incubators;innovation;International;Justice;K-Series Research Career Programs;Long-Term Care;Long-Term Care for Elderly;Measurement;Measures;Medication Management;Mental Health;Mentors;Mission;Modeling;Operative Surgical Procedures;Outcome;patient oriented;Patient Outcomes Assessments;patient safety;Patient-Centered Care;Patients;Pharmaceutical Preparations;Pharmacologic Substance;pharmacy benefit;Postdoctoral Fellow;Primary Care;Process;programs;Recovery;Research;Research Personnel;Resources;Safety;Scientist;Standardization;success;Suicide prevention;Surgeon;System;team-based care;Technology;Testing;Training and Education;Training Support;Transition Career Development Award (K22);Universities;Veterans;Veterans Health Administration;Vulnerable Populations;whole health;Work


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Continued improvement in human health depends on the translation of fundamental knowledge to clinical settings, and the integration of approaches from several different disciplines. The Stanford MSTP embraces and promotes these goals, training physician scientists to be academic leaders for future advances in biomedical research.

PI_NAMEs: CHUA, KATRIN F. (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: Medical Scientist Training Program


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunotherapy;Organ Transplantation;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PI_NAMEs: SYKES, MEGAN  (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Animal Model;Animals;Antigen Presentation;antigen-specific T cells;Antigens;B-Lymphocytes;Biological Assay;Carbohydrates;Cells;Chimera organism;Chimerism;Clonal Deletion;Defect;Development;effector T cell;engineered T cells;enzyme linked immunospot assay;Family suidae;Fluorochrome;Future;Genetic Engineering;Grant;Growth;Hematopoietic stem cells;Heterophile Antibodies;HLA-A2 Antigen;HLA-DQ8 antigen;Human;human pluripotent stem cell;human tissue;humanized mouse;Hybrids;immune function;Immune response;Immune system;Immune Tolerance;Immunologics;Immunosuppression;improved;insight;Insulin;Label;lentivirally transduced;Life;Methods;Monitor;mouse model;Mus;natural antibodies;Natural Killer Cells;novel;Organ;Patients;Peptides;porcine model;postnatal human;prevent;Proteins;reconstitution;Regulatory T-Lymphocyte;response;Structure;T cell differentiation;T cell reconstitution;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Thymectomy;Thymic epithelial cell;Thymus Gland;thymus transplantation;Tissues;tool;Toxic effect;Transgenic Organisms;Translating;Xenograft procedure

PROJECT_TITLE: Tolerance of Adaptive and Innate Human Anti-Pig Immune Responses in Humanized Mice


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

PHR: Project narrative  Textural aspects of food, termed mouthfeel, are important flavor qualities that can determine whether food is eaten or discarded, and thus, are essential factors for dietary health. Currently, little is known about the basic neuronal mechanisms underlying mouthfeel or the processes by which this flavor modality modifies taste. This work provides a comprehensive identification of mammalian mechanosensory neurons of the tongue and identifies mechanotransduction channels that underlie mouthfeel, with the long-term goal of understanding how mechanosensation impacts flavor perception.

PI_NAMEs: MOAYEDI-ESFAHANI, YALDA  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Afferent Neurons;Anatomy;Astringents;Auditory;Basic Science;Biology;calcium indicator;Cells;Complement;conditional knockout;Consumption;Cre driver;Cues;Deafferentation procedure;Dietary Factors;Dietary intake;Eating;Energy Intake;Esthesia;Family;feeding;Filiform Papilla;Food;Food Preferences;food quality;Fungiform Papilla;Future;Ganglia;Goals;Health;hedonic;Human;imaging study;in vivo calcium imaging;Ion Channel Gating;Knockout Mice;Knowledge;Label;Mechanical Stimulation;mechanical stimulus;Mechanics;Mechanoreceptors;mechanotransduction;Methods;Modality;Molecular;molecular marker;Morphology;multisensory;Mus;nerve supply;Neuroanatomy;Neurons;Nutrient;Oral;Oral cavity;Organ;Perception;Peripheral;Piezo 1 ion channel;Piezo 2 ion channel;Piezo ion channels;Play;Population;pressure;Process;Property;Publishing;Reporter;Research;response;Role;Sensory;Signal Transduction;SLC17A8 gene;Smell Perception;somatosensory;Stimulus;Structure of trigeminal ganglion;Surveys;Tactile;Taste Perception;Technology;Testing;Texture;Tongue;tongue papilla;Touch sensation;Transgenic Mice;Transgenic Organisms;Trigeminal System;Viscosity;Visual;Work

PROJECT_TITLE: Mechanosensory substrates of flavor in the mammalian tongue

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Social animals depend on vocal communication for survival in many contexts, and the brain must extract information from acoustic features of calls and communicate with circuits for appropriate behavioral responses. Depending on the call meaning, this processing must occur over time scales needed for guiding various behaviors. The research proposed here tests the overall hypothesis that top-down circuits in the auditory system facilitate vocalization-guided behaviors across contexts, using multiple methods for monitoring and manipulating activity in neurons and ensembles to dissect the circuits involved in driving behavior.

PI_NAMEs: LEMESSURIER, AMY  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TITLE: Neural circuitry and population dynamics for perception of social vocalizations in the auditory pathway


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. It will also investigate the specific dynamic interactions among these phenomena in daily life and how they, as well as the neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in genetic investigations and early detection efforts.

PI_NAMEs: FULFORD, DANIEL C;HOLT, DAPHNE J (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Address;Affect;Amygdaloid structure;Basal Ganglia;Behavior;behavior prediction;Behavioral;Cellular Phone;design;digital assessment;disability;Disease;Early Diagnosis;Ecological momentary assessment;experience;Face;follow-up;functional disability;functional improvement;Functional Magnetic Resonance Imaging;General Population;Genetic;Hippocampus;Impairment;improved;in vivo;Individual;Individual Differences;insight;Intervention;intimate behavior;Investigation;Knowledge;Life;Link;Loneliness;longitudinal design;Measurement;Measures;medial temporal lobe;mobile computing;Modeling;Monitor;Mood Disorders;mortality;Motivation;neural;neural correlate;neural model;neurobehavioral;neurobiological mechanism;neuroimaging;Neurophysiology - biologic function;new therapeutic target;novel;novel strategies;Participant;Personal Space;personalized intervention;Persons;Phenotype;Play;predicting response;prevent;Process;psychologic;psychosocial;Psychotic Disorders;Quality of life;Reporting;Research;response;Rewards;Schizophrenia;severe mental illness;smartphone based assessment;social;Social Behavior;social contact;social determinants;Social Interaction;Social isolation;Social Network;Social Perception;Stimulus;System;Testing;Thalamic structure;Time;trait;Variant;Work

PROJECT_TITLE: Neurobehavioral mechanisms of social isolation and loneliness in serious mental illness


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Methamphetamine;Opioid Misuse and Addiction;Opioids;Patient Safety;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PI_NAMEs: POTTER, JENNIFER SHARPE;SHOPTAW, STEVEN J;TRIVEDI, MADHUKAR H. (contact)

PROGRAM_OFFICER_NAME: DOBBINS, RONALD

PROJECT_TERMS: addiction;American Indians;Area;Arkansas;Buprenorphine;Bupropion;Caring;Cause of Death;clinical care;Clinical Treatment;Clinical Trials Network;cohort;Collaborations;Development;dissemination science;Doctor of Philosophy;Dose;Electronic Health Record;Ethnic Population;experience;Funding;Genetic Complementation Test;Geographic Locations;Geography;Health Sciences;Healthcare Systems;Helping to End Addiction Long-term;HIV;HIV/HCV;Immigrant;implementation science;implementation study;improved;Informatics;innovation;Leadership;Louisiana;Measurement;Medical center;Methamphetamine use disorder;Naltrexone;Names;National Institute of Drug Abuse;next generation;Oklahoma;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid use disorder;patient population;Persons;Pharmacotherapy;Primary Care;Productivity;Protocols documentation;Public Health;Publishing;racial diversity;racial population;Research;Research Design;Research Personnel;Resources;response;Rural;Science;Scientist;screening;Site;Speed;Stimulant;stimulant use disorder;substance misuse;substance use;Substance Use Disorder;Texas;Training;Transcranial magnetic stimulation;Translational Research;Underinsured;United States National Institutes of Health;Universities


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative of Parent U01 AG071450 The overall goal of this project is to collect and disseminate critical data on cognitive, physical, and sensory functioning and risk for Alzheimer’s Disease and Related Dementias (ADRD) in Wave VI of the National Longitudinal Study of Adolescent to Adult Health (Add Health), when participants will be in their mid-40s. These new data, when combined with Add Health’s existing collection of extraordinarily rich multi-level and longitudinal measures and its new Wave VI data, will facilitate the scientific community’s understanding of the interplay of social, economic, behavioral, and biological factors that influence cognitive, physical, and sensory functioning in midlife and lead to ADRD in later life. Moreover, because Add Health is a diverse nationally representative sample, adding these data to Wave VI will greatly increase understanding of cognitive, physical, and sensory functioning within key health disparity populations in the United States.

PI_NAMEs: AIELLO, ALLISON E;HUMMER, ROBERT A (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Asian;Back;Behavioral;Biological;Biological Factors;Biological Testing;Black race;Brain;Certification;Characteristics;Cognition;Cognitive;cognitive function;cognitive testing;cohort;Collection;Communities;Complex;computerized data processing;Consumption;cost;Coupled;Data;Data Collection;Data Set;Dedications;dementia risk;design;Dimensions;Disparity;Documentation;Early identification;Economics;Education;Eligibility Determination;eligible participant;Ensure;Environment;ethnic diversity;Ethnic Population;experience;follow-up;Foundations;Future;Goals;Government;Health;Health behavior;health data;health disparity;health disparity populations;Hispanic;Hour;Impaired cognition;innovation;Institution;Interview;Interviewer;late life;Life Cycle Stages;Longitudinal Studies;Measurement;Measures;member;middle age;Minor;Minority;National Longitudinal Survey of Adolescent to Adult Health;Nonrespondent;Online Systems;pandemic disease;Parents;Participant;participant interview;Persons;Physical assessment;Physical Function;Play;Politics;Population;post-pandemic;Process;prospective;Quality Control;Race;racial diversity;Research;response;Rest;Risk;Risk Factors;Risk Marker;Sample Size;Sampling;Science;Sensory;Signs and Symptoms;social;socioeconomics;Subgroup;success;Surveys;Testing;Time;Training;Travel;Trust;United States;Visit;Work;Writing

PROJECT_TITLE: Add Health Wave VI Fieldwork Supplement


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: CLARKSVILLE

ORG_NAME: NEURONASCENT, INC.

PHR: Project Narrative Results from the proposed non-clinical, long-term safety studies of NNI-362 in dogs and rats and the further scale-up of GMP material that is formulated into chewable gel caps will allow for the ongoing clinical development of Phase 2 proof-of-concept trial in mild to moderate Alzheimer’s patients. As proposed in the Specific Aims, long-term administration of NNI-362 (6-months) in male and female rats and dogs is required in order to treat humans for the same length of time, which should be sufficient to observe neuron regeneration in aged Alzheimer’s patients. The completion of Phase1a placebo-controlled trial of NNI-362, appears to demonstrate safety and potential efficacy by reversing an early brain-specific AD progression biomarker (i.e., phosphoTau181) and Neuronascent further hypothesizes that the longer-term administration of NNI-362 over a six-month period will promote neuron regeneration resulting in the reversal of cognitive impairment and functional deficits in mild to moderate AD patients.

PI_NAMEs: KELLEHER-ANDERSSON, JUDITH A (contact)

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Adult;aged;Aging;Alzheimer's disease patient;Alzheimer's disease therapy;Behavioral;Brain;Canis familiaris;capsule;Clinical;clinical development;Contractor;Cyclic GMP;Disease;disease model;Dose;experience;Failure;FDA approved;Female;follow-up;Formulation;Gel;Hippocampus;Human;Impaired cognition;Length;Liquid substance;male;manufacture;meetings;Methods;neuron regeneration;Neurons;neuroprotection;Neuroprotective Agents;Pathology;Patients;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;phase II trial;placebo controlled trial;preclinical study;progression marker;Rattus;regenerative therapy;Safety;safety study;safety testing;scale up;Time;treatment duration;trial planning;Update

PROJECT_TITLE: Completion of Non-clinical long-term GLP safety and GMP manufacture for first-in-class neuron regenerative therapy, NNI-362 Phase 2 POC AD trial


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Sepsis

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE This project will study how antibiotic-resistant bacteria evolve in vivo during gastrointestinal tract colonization and bloodstream infection in hospitalized patients. This study will generate new insights into how antibiotic- resistant bacteria cause disease, uncover new targets for therapeutic development, and inform efforts to improve the treatment and prevention of antibiotic-resistant infections in hospitalized patients.

PI_NAMEs: VAN TYNE, DARIA N (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Animals;Antibiotic Resistance;antibiotic resistant infections;antibiotic tolerance;Antibiotics;Antigens;Bacteremia;Bacterial Antibiotic Resistance;Bacterial Genes;bacterial resistance;Blood;Blood Circulation;candidate identification;Cell surface;Cell Wall;Clinical Research;combat;comparative genomics;Death Rate;Disease;DNA-Directed RNA Polymerase;Enterococcus;Enterococcus faecium;Environment;ESKAPE pathogens;experience;Face;Foundations;Gastrointestinal tract structure;Genes;Genetic;genetic analysis;Genetic Transcription;genome sequencing;genome-wide;Growth;gut colonization;Healthcare Systems;Hospitalization;Host Defense;Human;Immune;Immunocompromised Host;improved;in vivo;Individual;Infection;Infectious Diseases Research;insight;Intervention;Mediating;Medical center;Methyltransferase;Microbial Biofilms;Molecular Probes;mortality;mouse model;Muramidase;Mutation;neutrophil;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Nutrient;Oral;pathogen;Pathogenesis;Pathway interactions;Patients;Polysaccharides;Population;Population Genetics;Population Study;pressure;Prevention;Recurrence;recurrent infection;Resistance;response;Ribosomal Proteins;Ribosomes;Route;Sampling;Sepsis;Site;Specimen;therapeutic development;Time;Translations;transmission process;Universities;Vancomycin Resistance;Vancomycin resistant enterococcus;Vertebrates;whole genome;Work

PROJECT_TITLE: Adaptation of vancomycin-resistant enterococci during bloodstream infection

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Comparative Effectiveness Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Health Services;Patient Safety;Pediatric;Precision Medicine

ORG_CITY: PHOENIX

ORG_NAME: PHOENIX CHILDREN'S HOSPITAL

ORG_STATE: AZ

PHR: Cleft palate is the most common pediatric craniofacial anomaly, and up to 40% of children with cleft palate will develop severe limitations in speech intelligibility and acceptability due to velopharyngeal insufficiency (VPI). This research will compare the effectiveness of existing surgical procedures for VPI, establishing which procedures are most effective at improving speech and determining the risks of each procedure. The results will directly contribute to NIDCR’s mission to improve the health of children with craniofacial anomalies by enabling surgeons to select the most effective, least harmful surgical procedure for each child with VPI.

PI_NAMEs: SITZMAN, THOMAS JAMES (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Affect;Anatomy;Behavior;Child;Child Health;Childhood;Cleft Palate;comparative effectiveness study;compare effectiveness;cost;cost effective;Craniofacial Abnormalities;Crying;Decision Making;Deformity;early experience;effectiveness evaluation;Endoscopes;Enrollment;Exhibits;experience;Goals;Growth;Image;imaging modality;improved;Interview;Knowledge;Language;Length;Literature;Magnetic Resonance Imaging;Measures;Mission;morphological criteria;Morphology;Movement;Muscle;Nasopharyngoscopy;National Institute of Dental and Craniofacial Research;Nose;notch protein;Obstruction;Obstructive Sleep Apnea;operation;Operative Surgical Procedures;Outcome;Palate;palate repair;Pathologist;Patient Compliance;Patient Outcomes Assessments;Patient Selection;Patients;Pattern;peer;Performance;personalized approach;personalized medicine;Population;Procedures;Process;Quality of life;recruit;repaired;Research;Resolution;Risk;Risk Reduction;Sampling;Secondary to;Selection Criteria;Self Perception;Speech;Speech Intelligibility;Speech Sound;Subgroup;Surgeon;Symptoms;Testing;treatment planning;United States;Variant;Velopharyngeal Insufficiency;Visualization

PROJECT_TITLE: Velopharyngeal insufficiency following cleft palate repair: a comparative effectiveness study of existing surgical procedures and identification of criteria to guide a personalized treatment approach


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: In this administrative supplement we propose to investigate dengue naïve populations that are been infected for the first time with dengue viruses (DENV) in Argentina and will study immune responses elicited by the Takeda vaccine (Qdenga) in naïve and previously infected individuals. We will leverage approaches currently used in the VIVA parent grant to analyze responses to DENV infections and vaccinations taking advantage of the introduction of dengue vaccines for the first time in Argentina.

PI_NAMEs: FERNANDEZ-SESMA, ANA  (contact);SIMON, VIVIANA A

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: adaptive immune response;Administrative Supplement;Argentina;Attenuated;Biological Models;Case Study;chemokine;cytokine;Data;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Disease Outbreaks;Dose;experience;Flow Cytometry;high dimensionality;Human;Immune response;Individual;Infection;Innate Immune Response;Latin America;Measurement;parent grant;Phenotype;Population;Recording of previous events;response;Sampling;Serotyping;Techniques;Thailand;Time;Tonsil;transcriptome;United States National Institutes of Health;Vaccination;vaccine immunogenicity;vaccine response;vaccine trial;Vaccinee;Vaccines;Virus

PROJECT_TITLE: Phenotyping of human immune responses to dengue vaccination and infection in Argentina


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Patient Safety;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: IRVINE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative At the conclusion of this application, we will have developed and tested a mobile-based culturally adapted intervention that is aimed at improving the surgical experience of Latinx families and children undergoing outpatient surgery. We strongly believe that this innovative culturally adapted mobile-based intervention will better prepare Latinx children for surgery, reduce pain, anxiety and opioid requirements and improve the clinical course and family experience (better satisfaction scores). Once tested, we plan to disseminate this culturally adapted mobile-based intervention to all surgical facilities providing services to Latinx children and their families in the US.

PI_NAMEs: KAIN, ZEEV  (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Acceleration;Adult;Age;Algorithms;Ambulatory Surgical Procedures;Analgesics;animation;Anxiety;anxiety reduction;attentional control;Award;Behavior Therapy;Behavioral;Child;Clinical;clinical practice;community collaboration;Companions;comparison intervention;Coping Skills;cost;culturally appropriate intervention;Data;Delirium;Development;disparity reduction;Distress;Educational process of instructing;effective intervention;effectiveness evaluation;ethnic minority;Event;evidence base;Evidence based intervention;experience;Family;formative assessment;Growth;handheld mobile device;Health Personnel;Healthcare;heuristics;Home;Impairment;improved;innovation;Internet;Intervention;Language;Latinx;Latinx population;mHealth;mhealth interventions;Mobile Health Application;Modeling;Operative Surgical Procedures;Opioid;opioid use;Output;Pain;Pain management;pain reduction;Parents;Patients;Persons;Phase;Physical Function;Population;Postoperative Pain;Postoperative Period;postoperative recovery;Process;psychologic;Recovery;Research;satisfaction;Services;surgery outcome;surgical disparities;Target Populations;Testing;United States National Institutes of Health;usability

PROJECT_TITLE: Latinx Children and Surgery


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PI_NAMEs: BOYCE, SABRINA CHRISTINE (contact)

PROJECT_TITLE: CE20-001 Evaluating Practice-based Programs, Policies, and Practices from CDCs Rape Prevention and Education (RPE) Program: Expanding the Evidence to Prevent Sexual Violence - 2020


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Clinical Research;Kidney Disease;Patient Safety;Urologic Diseases

ORG_CITY: NASHVILLE

ORG_NAME: ENDOTHEIA, INC.

ORG_STATE: TN

PHR: Narrative: Public Health Relevance Of the 3.5 million Americans who suffer from kidney stones each year, 230,000 have large stone volumes that require either invasive surgery, or long-duration endoscopy which incurs high complication rates. To remove stones faster, we propose a new device that transforms almost instantaneously from an endoscope to a steer- able catheter with a large open lumen for suctioning out stone fragments. Success in this research will re- duce operation times, improve stone-free rates, and make many more patients candidates for minimally invasive ureteroscopy.

PI_NAMEs: GAFFORD, JOSHUA B (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TITLE: Breaking the Scope Port Size Barrier: A New Kind of Endoscope that Removes Large Kidney Stones Rapidly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(90)-B]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Women's Health Research

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Sex differences in outcomes following viral infections are well-described and may reflect sexual dimorphism in NK cell composition and effector function. This proposal will define how an X chromosome-linked epigenetic regulator, UTX, controls natural killer (NK) cell effector responses to viral infection and is responsible for NK cell sex differences. A deeper understanding of the cellular and molecular mechanisms of NK cell sex differences will lead to new insights into NK cell function and strategies for optimizing anti-viral immune responses.

PI_NAMEs: O'SULLIVAN, TIMOTHY E;SU, MAUREEN A (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Ablation;Anti-viral Response;antiviral immunity;Apoptosis;Apoptotic;BCL2 gene;Binding;Biological Assay;Cell Count;Cell Maturation;Cell Physiology;cell type;Cell-Mediated Cytolysis;Cells;Chromatin;Chromatin Remodeling Factor;CRISPR/Cas technology;cytokine;Cytomegalovirus;Cytomegalovirus Infections;cytotoxic;cytotoxicity;Data;Development;differential expression;Disease;Disparity;Effector Cell;EP300 gene;Epigenetic Process;epigenomic profiling;Female;fitness;Gene Expression;Genes;Genetic Transcription;genomic locus;Genomics;Gonadal Hormones;Granzyme;Health;histone demethylase;Homeostasis;Hormones;Human;Immune;Immune response;Immunotherapy;Impairment;improved outcome;In Vitro;in vivo;Inflammatory;insight;Interferon Type II;Intervention;Knowledge;Link;Lymphocyte;male;Mammals;Mediating;Methyltransferase;Molecular;mouse model;Murid herpesvirus 1;Mus;Natural Killer Cells;new therapeutic target;Outcome;p300/CBP-Associated Factor;perforin;personalized therapeutic;Phenocopy;Positioning Attribute;Predisposition;Production;programs;recruit;Regulation;Resistance;response;Role;Sampling;sex;Sex Bias;Sex Chromosomes;Sex Differences;sexual dimorphism;System;Testing;Viral;Viral Cancer;Virus Diseases;women versus men;X Chromosome;X Inactivation

PROJECT_TITLE: Sex Differences in NK Cells Mediated by X-linked UTX

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Medication errors or adverse events are a major public health problem causing thousands of deaths annually. This proposal aims to build wearable cameras with real-time computer vision algorithms to identify medications when initially selected by an anesthesiology provider during drug preparation or before injection to potentially prevent accidentally giving the wrong drug. Drug dose will also be determined and recorded in an electronic health record, potentially increasing record accuracy and decreasing manual tasks for anesthesiologists so they can focus on direct patient care.

PI_NAMEs: MICHAELSEN, KELLY  (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Accidents;Adverse event;Algorithms;Anesthesia procedures;Anesthesiology;auditory feedback;Award;Cessation of life;Clinical;Computer software;Computer Vision Systems;Computerized Medical Record;Consumption;cost;Databases;design;detection platform;Devices;direct patient care;dosage;Dose;Drug Compounding;Drug Delivery Systems;Electronic Health Record;Event;Eye;feasibility testing;Head;Hospitalization;Hospitals;Image;Injectable;Injections;Label;Learning Skill;Machine Learning;machine learning algorithm;Manuals;Medication Errors;Modality;Operating Rooms;patient safety;Patients;Pharmaceutical Preparations;prevent;Provider;provider adherence;Public Health;Reporting;Resolution;Syringes;System;Time;tool;Vial device;virtual;visual feedback;wearable device;Weight;Work

PROJECT_TITLE: Intelligent wearable system for preventing medication errors in anesthesiology


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: TSRL, INC.

ORG_STATE: MI

PHR: Project Narrative TSRL is developing a novel transdermal delivery product of zanamivir for the treatment and prevention of the flu. The proposed research will establish the proof-of-concept that effective treatment of the flu can be achieved with a self-administered microarray patch (MAP).

PI_NAMEs: LIPKA, ELKE  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: absorption;Achievement;Acute;Adamantane;Address;Agreement;Cessation of life;Circulation;Clinical;clinical development;Clinical Research;Communities;COVID-19 pandemic;design;Development;Development Plans;Devices;Disease;Drug Kinetics;economic impact;effective therapy;Effectiveness;Elderly;Ensure;Epidemic;Epithelium;Family suidae;flu;Formulation;Funding;Future;Grant;Human;improved;in vivo;Influenza;influenza epidemic;influenza outbreak;Influenza prevention;influenza virus strain;influenzavirus;Inhalation;Light;Liquid substance;Literature;Lung;manufacture;Manufactured Supplies;Marketing;Medical;Methods;Miniature Swine;Modeling;mortality;Needles;Neuraminidase inhibitor;novel;novel therapeutics;Oral;Oseltamivir;Pain;Painless;pandemic disease;Pathogenicity;patient population;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phase I Clinical Trials;Plasma;Population;Powder dose form;pre-Investigational New Drug meeting;preclinical study;prevent;programs;prototype;Publishing;Puncture procedure;Rattus;Recommendation;Reproducibility;Research;Resistance;resistant strain;respiratory;Respiratory System;Risk;Route;Safety;scale up;seasonal influenza;Seasons;Self Administration;Site;Skin;skin barrier;skin irritation;Small Business Innovation Research Grant;Syringes;System;Therapeutic;Toxicology;Transdermal substance administration;transmission process;treatment adherence;treatment duration;Vaccination;vaccine effectiveness;Vaccines;Visit;Work;zanamivir

PROJECT_TITLE: Novel, Self-Applied MicroArray Patch (MAP) of Zanamivir for Treatment of the Flu

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


ORG_CITY: WILMINGTON

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, DELAWARE

ORG_STATE: DE

PI_NAMEs: KAZAK, ANNE E (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Accountability;Achievement;Address;Advisory Committees;Advocate;Biomedical Research;career;career development;Caring;Centers of Research Excellence;cerivastatin;Child;Child Health;Child health care;Communities;Delaware;Doctor of Philosophy;Education;Elements;Ensure;Equity;Evaluation;Event;experience;Faculty;Family;Feedback;Fostering;Funding;Future;Goals;Health;health care availability;health care delivery;Health Care Research;Health Psychology;Health system;Healthcare Systems;Hospitals;Improve Access;Inequity;Infrastructure;innovation;Institution;Intervention;Lead;Leadership;Mentors;Mentorship;Methods;Mission;Monitor;multidisciplinary;operation;Operations Research;Patients;Pediatric Hospitals;Pediatric Research;Performance;Persons;Procedures;Process;Production;Program Development;programs;Provider;recruit;Reporting;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Role;Science;Scientific Evaluation;Site;skills;sound;Strategic Planning;Structure;success;synergism;System;systems research;Technology;technology intervention;Voice

PROJECT_TITLE: Research Expanding Access to Child Health (REACH)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: FAYETTEVILLE

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

PI_NAMEs: QUINN, KYLE PATRICK (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: BOSTON

ORG_STATE: MA

PI_NAMEs: SCHACHTER, STEVEN C. (contact)

PROJECT_TERMS: Acceleration;design;Development;Diagnostic;Diagnostic tests;HIV;innovation;point of care;programs;RADx Tech;Testing;United States National Institutes of Health;Viral Load result

PROJECT_TITLE: RADX INNOVATION FUNNEL FOR HIV DIAGNOSTICS - COORDINATION CENTER


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: LAM, WILBUR A (contact)

PROJECT_TERMS: Acceleration;design;Development;Diagnostic;Diagnostic tests;HIV;innovation;point of care;programs;RADx;RADx Tech;Testing;United States National Institutes of Health;Validation;Viral Load result

PROJECT_TITLE: RADx Innovation Funnel for HIV diagnostics – Validation Center


NIH_SPENDING_CATS: Bioengineering;HIV/AIDS

ORG_CITY: HADLEY

ORG_NAME: VENTUREWELL

PI_NAMEs: NEAL, REBEKAH ANNE (contact)

PROJECT_TERMS: Acceleration;commercialization;design;Development;Diagnostic;Diagnostic tests;HIV;innovation;point of care;programs;RADx Tech;Testing;United States National Institutes of Health;Viral Load result

PROJECT_TITLE: RADX INNOVATION FUNNEL FOR HIV DIAGNOSTICS - COMMERCIALIZATION CENTER


PROJECT_TERMS: Acceleration;Award;design;Development;Diagnostic;Diagnostic tests;HIV;innovation;point of care;programs;RADx Tech;Testing;United States National Institutes of Health;Viral Load result

PROJECT_TITLE: RADX INNOVATION FUNNEL FOR HIV DIAGNOSTICS - AWARD MANAGEMENT


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

PHR: PROJECT NARRATIVE This study will develop and validate stakeholder-informed quality measures to improve clinical care and outcomes for opioid-exposed infants. These quality measures will serve as pilot data for a pragmatic clinical trial to determine if clinician exposure to measures improves infant outcomes.

PI_NAMEs: LORCH, SCOTT A;PATRICK, STEPHEN W (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Academy;adverse outcome;Birth;Breast Feeding;Caring;Child Welfare;Clinical;clinical care;Clinical Data;Clinical effectiveness;Code;collaborative care;Communities;Data;Data Set;Development;Diagnosis;effectiveness measure;effectiveness study;Electronic Health Record;Emergency department visit;Equity;experience;Exposure to;Family;Foundations;Goals;Health;health care quality;Health Personnel;Health system;Healthcare;Hospitals;improved;improved outcome;Infant;infant outcome;innovation;Inpatients;Insurance Carriers;Length;Length of Stay;Link;Measures;Medicaid;Medical;Medicine;Methods;neglect;Neonatal Abstinence Syndrome;Opioid;opioid exposure;opioid use;opioid use disorder;Outcome;Outcome Measure;patient oriented;Performance;Perinatal;Personal Satisfaction;Pharmaceutical Preparations;Pharmacological Treatment;Policy Developments;Policy Maker;population based;Populations at Risk;Pragmatic clinical trial;Pregnant Women;Preventive service;Privatization;Process;Process Measure;provider behavior;Public Policy;Quality of Care;Randomized;randomized, clinical trials;readmission rates;Recommendation;Records;Reproducibility;Research;Research Personnel;response;Risk Adjustment;Safety;Sampling;standardized care;System;tool;US State;usability;Validity and Reliability;Variant;Vulnerable Populations;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Developing Quality Measures for Opioid-Exposed Infants

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Hip fracture risk is six- to eight-fold higher in adults with type 1 diabetes and occurs at a relatively young age. Bone mineral density alone does not explain the higher fracture risk in this population. However, little is known about bone quality in adults with type 1 diabetes. This study proposes to explore bone quality and strength at the hip in adults with long-standing type 1 diabetes compared to age-, gender-, and body mass index-matched controls without diabetes over a period of 3 years. Characterizing bone phenotype and understanding the effect of glycemic control on bone health will help us understand the mechanisms of bone fragility; and thus plan future interventions to improve bone health in this population.

PI_NAMEs: SHAH, VIRAL N (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: 20 year old;Acute;Address;Adult;Advanced Glycosylation End Products;Affect;Age;Area;Body mass index;bone;Bone Density;bone fragility;bone health;bone mass;bone quality;Bone Resorption;bone strength;Bone Tissue;bone turnover;Caring;Chronic;Clinical Trials;Closure by clamp;cohort;comparison control;coronary artery calcification;Diabetes Mellitus;Diagnosis;Elements;epidemiology study;Femur;Financial Hardship;fracture risk;Future;Gender;Geometry;glycemic control;high risk;Hip Fractures;Hip region structure;Hyperglycemia;Hypoglycemia;Impairment;improved;in vivo;indexing;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Intervention;Intervention Trial;Knowledge;Long-Term Effects;Measures;Mechanics;Morbidity - disease rate;mortality;non-diabetic;older adult;Osteoporosis;Patients;Persons;Phenotype;Population;Prevention approach;Property;Prospective, cohort study;Research;Research Project Grants;Risk;risk prediction model;Roentgen Rays;Role;skeletal;Testing;Thick;tibia;Time;Vertebral column;Work;X-Ray Computed Tomography

PROJECT_TITLE: Bone Health in Adults with Type 1 Diabetes


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative The ability to smell is necessary for long-term physical and behavioral health in humans. Epidemiological studies suggest that older adults with impaired olfactory perception have a 4-fold increase in mortality within 5 years, and an increasing number of studies detect significant correlation between olfactory deficits and the future onset of neurodegenerative disorders, including Alzheimer’s. The proposed research is motivated not only by the desire to solve a fascinating molecular mystery that constitutes the keystone of olfaction, but also by the need to obtain insight to a sensory modality critical for human health.

PI_NAMEs: PULUPA, JOAN M. (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Advisory Committees;Alleles;Alzheimer's Disease;Architecture;Axon;behavioral health;Binding;Binding Sites;Chemicals;Detection;Disease;DNA receptor;Enhancers;epidemiology study;experimental study;fascinate;Future;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genome;Goals;Health;Heterochromatin;Human;Image;insight;Institution;Laboratory Research;Lead;live cell imaging;Messenger RNA;Microscopy;Modality;Molecular;mortality;mutant;Nature;Neurodegenerative Disorders;Neurons;Nuclear;Nucleoproteins;older adult;Olfactory dysfunction;Olfactory Pathways;olfactory receptor;olfactory sensory neurons;Optics;particle;Phase;physical conditioning;Positioning Attribute;protein protein interaction;receptive field;receptor;Receptor Gene;recruit;Research;Sensory;Smell Perception;Specificity;stoichiometry;Technology;Training;transcription factor;Universities;Volatilization

PROJECT_TITLE: Identifying the mechanism of olfactory receptor gene regulation in olfactory neurons with live-cell imaging


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: 8. Project Narrative Due to intersectional stigma based on race, sexual orientation, and HIV-status, Black men who have sex with men (BMSM) and live with HIV (LWH) face multiple barriers to antiretroviral therapy (ART) adherence that increase the risk of virological failure, chronic inflammation, morbidity and mortality, and HIV transmission to HIV-negative sexual partners. Culturally-sensitive, evidence-based interventions (EBIs) for BMSM/LWH to address these barriers and improve ART adherence are still lacking. Through the proposed project, the candidate will design and pilot test a technology-enhanced, culturally-sensitive EBI for BMSM/LWH to address intersectional stigma-related barriers to ART adherence, to ultimately promote viral suppression and reduce chronic inflammation levels.

PI_NAMEs: NORCINI PALA, ANDREA  (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Address;Adherence;Affect;Affective;antiretroviral therapy;arm;Award;Behavior Therapy;Belief;Biological Markers;biopsychosocial;black men who have sex with men;Chronic;Clinical Psychology;Cognitive;Cognitive Therapy;compliance behavior;Computers;Coupled;COVID-19 pandemic;Data;design;Devices;Dimensions;Disclosure;Discrimination;distrust;Dose;empowerment;Enhancement Technology;Epidemic;Event;Evidence based intervention;expectation;experience;experimental arm;Face;Failure;Goals;Hair;handheld mobile device;high risk;HIV;HIV Seronegativity;Humor;Immunocompromised Host;improved;Individual;Inflammation;innovation;Interleukin-6;internalized stigma;Intervention;Intervention Studies;Interview;Measures;Medical;Memory;men;men who have sex with men;Mental Health;Mentored Research Scientist Development Award;Mentorship;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;news;Outcome;Participant;Pathway interactions;Patient Self-Report;perceived discrimination;Pharmaceutical Preparations;pilot test;primary outcome;Qualitative Research;Race;Randomized;Randomized, Controlled Trials;Reminder Systems;remote delivery;Research;Research Methodology;Risk;Risk Factors;Risk Reduction;secondary outcome;Sex Orientation;Sexual Partners;skills;social;Social Environment;social factors;Social isolation;Social Processes;social stigma;Stigmatization;structural determinants;substance use;System;Techniques;Telephone;Text Messaging;therapy adherence;Training;transmission process;Transportation;United States National Institutes of Health;Viral;Viral Load result

PROJECT_TITLE: A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Patient Safety;Pediatric;Prevention

ORG_CITY: Durham

ORG_NAME: RHO FEDERAL SYSTEMS DIVISION, INC.

ORG_STATE: NC

PHR: PROJECT NARRATIVE Characterized by an inability to create insulin, Type 1 diabetes (T1D) is a debilitating disease that can cause long-term damage to or even failure of various organs, leading to irreparable injuries such as blindness, amputation, stroke, and eventually death. These research funds would provide safety reporting, data management, and randomization support for studies investigating treatments for T1D in the Immune Tolerance Network (ITN).

PI_NAMEs: SCHMIDT, PETER N. (contact);SNYDER, CATHIE

PROGRAM_OFFICER_NAME: THOMAS, LEIGHTON A

PROJECT_TERMS: Amputation;authority;Autoimmune Diseases;Blindness;Cessation of life;Clinical Data;Clinical Research;Data;Data Collection;data management;design;Disease;Ensure;Failure;Funding;Health;Immune Tolerance;Injury;Insulin;Insulin-Dependent Diabetes Mellitus;Lead;Monitor;National Institute of Allergy and Infectious Disease;Organ;Pancreas;participant enrollment;participant safety;Randomized;Reporting;Research;rho;Safety;Safety Management;Serious Adverse Event;Stroke;Support System;web services

PROJECT_TITLE: RhoFED CDSMC


ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Upper respiratory virus infection (URVI) is responsible for 80% of asthma attacks; however, the underlying mechanisms remain poorly understood. This project is proposed to dissect the cellular and molecular mechanisms undelying the nose -lung cross talk, particularly how URVI causes asthma attacks. Findings from this research are expected to lead to not only novel preventive and therapeutic strategies for asthmatics, but also to define nasal mucosal immune system and subsequently facilitate nasal vaccine development against airborne pathogens. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page

PI_NAMEs: HUA, XIAOYANG  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TITLE: The nose-lung cross talk in upper respiratory virus infection induced asthma exacerbations

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Underserved, racial and ethnic minority communities are experiencing higher rates of COVID-19 cases and associated mortality compared to whites due to long standing social and structural inequities that also drive disparities in chronic diseases such as stroke, cardiovascular disease, diabetes, and hypertension. Patients with underlying chronic diseases who are recovering from COVID-19 depend on the support of family caregivers who are being exposed to the same pandemic and racial stressors, exposure that can affect the health and quality of life of both partners. The primary goal of this study is to test the efficacy of an adapted, telehealth-enhanced intervention that targets barriers impacting family illness management behaviors of survivor:carepartner dyads for improved quality of life and COVID-19/chronic disease related health outcomes.

PI_NAMEs: MAGWOOD, GAYENELL SMITH (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: 2019-nCoV;Address;Adult;Affect;African American;Age;Anxiety;arm;attentional control;barrier to care;Behavior;Behavioral;Cardiovascular Diseases;care delivery;Caring;Chronic;Chronic Disease;Chronic Kidney Failure;Communities;Community Health Aides;community intervention;comorbidity;contextual factors;COVID-19;COVID-19 impact;COVID-19 morbidity;COVID-19 mortality;COVID-19 pandemic;COVID-19 risk;COVID-19 survivors;Death Rate;design;Diabetes Mellitus;Discrimination;disorder risk;Disparity;Economically Deprived Population;efficacy testing;Environment;ethnic minority;experience;Exposure to;Family;Family Caregiver;Family Relationship;family support;Fatigue;Focus Groups;Future;Goals;Health;Health Benefit;health care availability;health inequalities;Health Personnel;Health Promotion;Health Status;Healthcare Systems;high risk;Hospitalization;Hypertension;Impairment;improved;Individual;Inequity;informal care;Information Management;innovation;Institutional Racism;intersectionality;Intervention;intervention effect;Interview;Linear Models;Link;Literature;Measures;Mental Health;Methods;Minority;minority communities;Minority Groups;minority health;minority patient;Modeling;mortality;Nurses;Older Population;Outcome;Pain interference;pandemic disease;pandemic impact;pandemic stressor;Patient Care;Patients;Pattern;people of color;PhenX Toolkit;physical conditioning;preference;pressure;psychosocial;Psychosocial Factor;Public Health;public health emergency;Qualitative Methods;Quality of life;Race;racial minority;racism;Recovery;Reduce health disparities;Research;Risk;risk mitigation;Role;rural area;SARS-CoV-2 infection;secondary outcome;Self Efficacy;Self Management;Sick Role;social;social determinants;Social Environment;social health determinants;Social Identification;Social status;Social support;social vulnerability;sociodemographic factors;socioeconomic disadvantage;Stress;stressor;Stroke;stroke patient;structural determinants;structural health determinants;Survivors;Symptoms;System;telehealth;Testing;theories;therapy design;Trauma;trauma exposure;Treatment Efficacy;underserved community;underserved minority;Underserved Population

PROJECT_TITLE: Improving the Collaborative Health of Minority COVID-19 Survivor & Carepartner Dyads Through Interventions Targeting Social and Structural Health Inequities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(58)R]


NIH_SPENDING_CATS: Burden of Illness;Cancer;Prevention

ORG_CITY: CALVERTON

ORG_NAME: INFORMATION MANAGEMENT SERVICES, INC.

ORG_STATE: MD

PI_NAMEs: ANNETT, DAVID  (contact)

PROJECT_TERMS: Area;Authorization documentation;Biomedical Computing;Cancer Burden;cancer care;Collection;data management;data registry;Development;Diagnosis;Division of Cancer Control and Population Sciences;Information Technology;Infrastructure;Knowledge;Maintenance;Malignant Neoplasms;Methodology;National Cancer Institute;neoplasm registry;Population;population based;Prevention;Reporting;SEER Program;Services;statistics;survivorship;Systems Development;web site

PROJECT_TITLE: DIVISION OF CANCER CONTROL AND POPULATION SCIENCES (DCCPS) BIOMEDICAL COMPUTING SUPPORT SERVICES


PROJECT_TITLE: DIVISION OF CANCER CONTROL AND POPULATION SCIENCES (DCCPS) BIOMEDICAL COMPUTING SUPPORT SERVICES_ CCDI Support


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: NATIONAL INSTITUTE ON AGING

PROJECT_TERMS: Alzheimer's Disease;Contracts;research and development

PROJECT_TITLE: AD R&D Contracts DBSR


NIH_SPENDING_CATS: Aging

PROJECT_TITLE: DBSR R&D Contracts


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Lung;Physical Injury - Accidents and Adverse Effects;Rare Diseases

ORG_CITY: PALO ALTO

ORG_NAME: INNOVATION PATHWAYS, LLC

PI_NAMEs: HART, BARRY  (contact)

PROJECT_TERMS: Acute;Animal Model;animal rule;Animals;Biological Markers;Characteristics;Critical Pathways;Development;Evaluation;Fumarates;Histologic;innovation;irradiation;kinase inhibitor;Lung;medical countermeasure;multiorgan injury;Organ;Pathway interactions;pharmacokinetics and pharmacodynamics;pharmacologic;Preparation;Radiation;Radiation exposure;Radiation induced damage;radiation-induced lung injury;radiological imaging;receptor;small molecule;Toxicology;Transforming Growth Factor beta

PROJECT_TITLE: THE PHARMACOLOGICAL DEVELOPMENT OF IPW-5371 FUMARATE AS A RADIATION MEDICAL COUNTERMEASURE FOR THE TREATMENT OF DELAYED RADIATION LUNG INJURY UNDER THE FDA ANIMAL RULE


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE The UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation (CERSI) conducts collaborative research in innovative regulatory science. This research enhances the FDA’s public health mission including the evaluation of safe and effective medical products. In addition, the CERSI develops training and outreach programs for the purpose of training students, postdoctoral fellows and career scientists in regulatory sciences.

PI_NAMEs: ALTMAN, RUSS BIAGIO;GIACOMINI, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: SEPULVEDA, KRISTIN

PROJECT_TITLE: UCSF-Stanford Center of Excellence in Regulatory Science and Innovation


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PHR: This proposal is to establish the Northern Pacific Global Health Leadership, Education, And Development for Early-career Researchers (NPGH LEADERs) Consortium – a research training program directed by the University of Washington in partnership with the Universities of Hawaii, Michigan and Minnesota with international partnerships in Cameroon, Ghana, India, Kenya, Liberia, Nepal, Peru, Thailand, and Uganda. The goal of this Consortium is to provide outstanding mentored research training to U.S. and LMIC post-doctoral and U.S. pre-doctoral trainees at international partner institutions in order to create the next generation of independent global health scientists and leaders.

PI_NAMEs: DATTA, DIBYADYUTI ;JOHN, CHANDY C.;MOYER, CHERYL A.;PRASAD, SHAILENDRA ;ZUNT, JOSEPH RAYMOND (contact)

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TITLE: NPGH LEADERs - NCI - Mwachaka

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(58)-R]