ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: New research methods have made it possible to study hundreds of human diseases in parallel. By combining a high-throughput CRISPR technology with state-of-the-art sequencing, this project will generate hundreds of distinct models of human diseases in zebrafish, then quantify the molecular and functional changes that occur in every disease model. Computational methods will be used to categorize diseases, elucidate the underlying disease processes, and predict targets for treating them.

PI_NAMEs: GAGNON, JAMES ALAN;PETERSON, RANDALL T (contact)

PROJECT_TERMS: Animal Model;Bar Codes;Behavior;Behavioral Assay;behavioral phenotyping;Biological Assay;blood glucose regulation;Cardiovascular Physiology;Categories;Cells;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Computational Technique;Computer Models;Computing Methodologies;CRISPR/Cas technology;Data;Data Collection;data exploration;data platform;Descriptor;Disease;disease model;droplet sequencing;Generations;Genes;Genetic;Genetic Diseases;Genetic Models;Genetic Transcription;Genotype;Health;Human;human disease;human model;improved;Individual;interest;Intervention;Larva;Machine Learning;Manuals;Maps;Mathematics;Measurement;Measures;Microfluidics;Modeling;Molecular;molecular phenotype;Morphology;multidimensional data;multimodality;mutant;Mutate;Mutation;Organism;pharmacologic;Phenotype;phenotypic data;Physiological;Process;Research;Research Methodology;Resources;single-cell RNA sequencing;System;targeted treatment;Technology;Therapeutic Intervention;tool;transcription factor;transcriptomics;Whole Organism;Zebrafish;zebrafish genome

PROJECT_TITLE: Multimodal phenotyping of zebrafish models of human disease


ADMINISTERING_IC: EB

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ALBUQUERQUE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SANDIA CORP-SANDIA NATIONAL LABORATORIES

ORG_STATE: NM

PHR: Project Narrative In a national laboratory-industry partnership, we propose a novel sensor for magnetoencephalography (MEG), a pulsed optically pumped magnetometer (OPM) featuring 1) exceptional gradiometrically inferred sensitivity (2 ft/rt-Hz), 2) wide bandwidth (220 Hz), 3) simultaneous triaxial signal detection using a single sensing volume, and 4) closed-loop operation on all three axes. In a demonstration of the versatility, utility, and high performance of the new OPM, we will noninvasively measure gamma waves in infants, which have high frequency and low amplitude and are involved in cognitive phenomena and large-scale brain-network activity, and detecting them non-invasively will inform a broad range of studies examining neurodevelopmental and neurodegenerative disorders. Due to individual sensor placement and the resulting increased in signal-to-noise ratio, MEG using OPMs is the best method to detect and localize gamma waves in infants, and our OPM compared to existing commercial OPMs will show marked improvement in gamma wave detection through dramatically improved sensitivity, bandwidth, and accuracy.

PI_NAMEs: SCHWINDT, PETER D. D. (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TITLE: Closed-Loop Triaxial Optically Pumped Magnetometers for High-Sensitivity and High-Bandwidth Magnetoencephalography Measurements of the Developing Brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: OVERALL PROJECT NARRATIVE Small cell lung cancer (SCLC) displays tumor heterogeneity with distinct transcriptome changes, however, the specific molecular determinants of treatment response remains unclear. This project will investigate how high levels of DNA replication stress in SCLC creates a therapeutic vulnerability that can be exploited with new druggable targets in the replication stress space.

PI_NAMEs: HUANG, TONY TUNG (contact);POIRIER, JOHN THOMAS

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Accounting;Automobile Driving;biological adaptation to stress;Biological Markers;biomarker identification;Biophysics;c-myc Genes;Camptothecin;Cancer Biology;Cancer cell line;Cancer Model;Cancer Patient;cancer subtypes;cancer therapy;Cell Cycle Checkpoint;Cell Cycle Progression;Cell Line;Cell Proliferation;Chemoresistance;chemotherapy;Cisplatin;Clinical;clinically relevant;Collaborations;Computational Biology;Core Facility;cytotoxicity;design;Disease;DNA biosynthesis;DNA Damage;DNA lesion;DNA replication fork;DNA-Directed DNA Polymerase;Drug Combinations;experimental study;Extensive Stage;Family member;Feedback;Fertilization;Fostering;functional genomics;Genetic Transcription;Genetically Engineered Mouse;Genomic Instability;Immune checkpoint inhibitor;Immunotherapeutic agent;improved;insight;Knowledge;Lead;Lesion;loss of function;Malignant neoplasm of lung;Malignant Neoplasms;Mediation;Microscopy;Molecular;Molecular Biology;Monitor;mouse model;mutant;Mutation;new therapeutic target;novel;Outcome;Pathway interactions;patient derived xenograft model;Pharmaceutical Preparations;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;predictive marker;Process;Productivity;Program Research Project Grants;programs;Proliferating;RB1 gene;Relapse;repaired;replication stress;Research;response;Role;Sampling;Science;small cell lung carcinoma;stress tolerance;targeted cancer therapy;Techniques;Therapeutic;therapeutic target;therapeutically effective;TP53 gene;transcriptome;treatment response;tumor;tumor heterogeneity;tumor-immune system interactions;tumorigenesis;Work

PROJECT_TITLE: Investigating and Targeting Replication Stress in  Small Cell Lung Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-M (J1)]


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer;Rare Diseases

PHR: CORE A NARRATIVE This core will provide the administrative management of the Program, plans for monitoring of progress, and plans for effective coordination and communication within the Program. The administrative core is especially critical to this program project to ensure that the scientific Cores and Projects are communicating and collaborating seamlessly and effectively within the NYU Langone Health community.

PI_NAMEs: HUANG, TONY TUNG (contact)

PROJECT_TERMS: Collaborations;Communication;Community Health;conflict resolution;Elements;Ensure;Goals;Human Resources;Institution;meetings;member;Monitor;Office of Administrative Management;operation;Persons;Policies;Postdoctoral Fellow;Preparation;programs;Progress Reports;recruit;Regulation;replication stress;Research;Research Personnel;Resources;Services;small cell lung carcinoma;Students;Teleconferences;United States National Institutes of Health

PROJECT_TITLE: Administrative Core


PHR: PROJECT NARRATIVE  Despite recent advances in targeted therapy and immune checkpoint blockade, medicines that target DNA replication continue to play a major role in cancer treatment. Unfortunately, responses can often be transient due to a variety of resistance mechanisms. This project aims to understand the fundamental biology of Schlafen family member 11, a potent sensitizer to replication stress in small cell lung cancer.

PI_NAMEs: POIRIER, JOHN THOMAS (contact)

PROJECT_TERMS: Acute;Animal Model;Benchmarking;biological adaptation to stress;Biology;cancer therapy;candidate identification;candidate marker;candidate validation;Cell Cycle;Cell Death;Cell Line;Cell Physiology;Cells;Chemicals;Chemoresistance;Chemosensitization;chemosensitizing agent;chemotherapy;Chronic;Cisplatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complementary DNA;coping;Data;Defect;Deubiquitination;Development;dimer;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair;DNA Repair Gene;DNA replication fork;drug candidate;Drug Targeting;epigenetic silencing;Etiology;Etoposide;Experimental Designs;experimental study;Family member;gene repair;Genes;Genetic Epistasis;Genetically Engineered Mouse;Hand;Human;immune checkpoint blockade;Impairment;In Vitro;in vivo;inhibitor;Innate Immune Response;interest;Knock-out;Label;Lesion;lung cancer cell;Malignant Neoplasms;Mediator;Medicine;Methods;Modeling;Molecular;monomer;mutant;Mutation;novel therapeutic intervention;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphorylation Inhibition;Platinum Compounds;Play;Poisoning;Polymerase;Post-Translational Protein Processing;prevent;Process;Protein Dephosphorylation;Protein phosphatase;Proteins;Proteomics;Regulation;replication stress;Reporting;Research Design;Resistance;resistance mechanism;response;response biomarker;RNA Interference;Role;Series;Signal Transduction;Single-Stranded DNA;small cell lung carcinoma;Stress Response Signaling;targeted treatment;Testing;Therapeutic;therapy resistant;Time;Topoisomerase Inhibitors;Translational Repression;tumor;tumor xenograft;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Replication Stress Sensing and Signaling Defects in SCLC


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Rare Diseases

PHR: PROJECT 2 NARRATIVE Project 2 will investigate the mechanisms of replication stress tolerance in naïve and chemo-resistant SCLC cells. This project will help clarify the biological role of these tolerance pathways as part of a multidisciplinary program project; our work together will allow us to exploit the vulnerabilities that arise and discover more durable targeted therapeutics for relapsed SCLC patients.

PROJECT_TERMS: Acceleration;Address;Biological;biological adaptation to stress;BRCA2 gene;Buffers;cancer cell;Cell Cycle Progression;Cell Line;Cell Survival;Cells;Cellular biology;CHEK1 gene;Chemoresistance;Clinical;Collaborations;Computer Analysis;cytotoxicity;Disease;DNA;DNA biosynthesis;DNA fiber assay;DNA Primase;DNA replication fork;DNA-Directed DNA Polymerase;Event;experimental study;Feedback;functional genomics;Genetic Transcription;Genetically Engineered Mouse;genome integrity;genome-wide;Genomic Instability;Growth;High-Throughput DNA Sequencing;imaging approach;imaging platform;Immune response;improved;Intrinsic factor;Knowledge;Lesion;live cell imaging;Measures;Mediating;Mediation;Microscopy;Mitotic;Modeling;Molecular;Molecular Biology;Monitor;multidisciplinary;mutant;Mutation;nanoscale;neoantigens;novel;Okazaki fragments;Organoids;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Play;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;pre-clinical;Process;Production;programs;Proteins;Proteomics;RB1 gene;Relapse;replication stress;Research;Role;Signal Pathway;single molecule;small cell lung carcinoma;stress tolerance;Structure;superresolution microscopy;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Research;TP53 gene;transcriptome;tumor;Work

PROJECT_TITLE: Mechanisms of Replication Stress Tolerance in SCLC


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE The limitations in our understanding of replication-fork lesions and their mechanisms of repair in small-cell lung- cancer (SCLC) presents a critical barrier for improving treatment and addressing resistance. This project is highly significant because it examines complex levels of DNA damage and repair pathways in SCLC that have direct relevance to treatment outcome. Our proposal addresses key issues that are directly related to therapeutic response and resistance in cancer.

PI_NAMEs: ROTHENBERG, ELI  (contact)

PROJECT_TERMS: Address;Affect;Biological Assay;c-myc Genes;cancer cell;Cancer Patient;cancer subtypes;Categories;Cell Cycle;Cell Line;Cell model;Cells;Cellular biology;cellular engineering;cellular sensitization;chemotherapy;Cisplatin;Clinical;Collaborations;Combined Modality Therapy;Complex;Data;Data Analyses;Defect;design;Development;DNA;DNA Damage;DNA lesion;DNA Repair Pathway;DNA replication fork;DNA Structure;Enhancing Lesion;Experimental Designs;experimental study;Feedback;Genetic;Genetic Transcription;Genomics;Image;Immune;immune activation;Immune response;Immunotherapy;improved;inhibitor;innovation;Knowledge;Lesion;live cell imaging;Location;Malignant Neoplasms;Maps;Measurement;Measures;Microscopy;Modality;Modeling;Molecular;Molecular Biology;Monitor;Mutation;new therapeutic target;novel;Outcome;Pathway interactions;Poly(ADP-ribose) Polymerase Inhibitor;Process;programs;Proliferating;Proteomics;Rationalization;Repair Complex;repaired;replication stress;Research;Resistance;response;Role;Signal Transduction;single molecule;single-cell RNA sequencing;Site;small cell lung carcinoma;small molecule inhibitor;targeted treatment;Techniques;therapy resistant;Toxic effect;Treatment outcome;treatment response;tumor;Uncertainty;Visualization;Work

PROJECT_TITLE: Repair Mechanisms of Replication fork Lesions in SCLC


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

PHR: NARRATIVE Current therapeutic interventions for small cell lung cancer (SCLC) are limited in scope. In this study, we propose using mouse models with different co-genetic alteration to better understand the heterogeneity and replication stress that hindered the treatment outcomes for SCLC patients. Furthermore, we will utilize these models to evaluate rational drug combinations that can generate effective and durable responses for this dismal disease.

PI_NAMEs: WONG, KWOK KIN  (contact)

PROJECT_TERMS: Affect;Aftercare;Animal Cancer Model;anti-cancer;ASCL1 gene;ATAC-seq;Basic Science;BETA2 protein;Biological;biological adaptation to stress;Biological Assay;c-myc Genes;cancer cell;cancer heterogeneity;Cancer Model;Cancer Patient;cancer subtypes;CDK2 gene;Cell Cycle Progression;Cell Line;Cellular Assay;Characteristics;Chemotherapy and/or radiation;Classification;Clinic;clinically relevant;Combined Modality Therapy;CRISPR/Cas technology;Development;Disease;DNA replication fork;DNA Replication Induction;Drug Combinations;Drug resistance;Enhancers;Environment;Gene Mutation;Gene Silencing;Genes;Genetic Transcription;Genetically Engineered Mouse;Genomic Instability;Goals;Harvest;Heterogeneity;Human;Image;Immune;Immune response;Immunocompetent;Immunotherapeutic agent;Immunotherapy;In Vitro;inhibitor;inhibitor therapy;innovation;insight;Intrinsic factor;Lesion;loss of function;lung cancer cell;Lung Neoplasms;Malignant Neoplasms;Mediating;Modeling;Molecular;Mouse Cell Line;mouse model;Mus;Mutation;MYC gene;Neurosecretory Systems;novel;novel therapeutics;overexpression;PARP inhibition;Pathway interactions;Patients;PD-1 blockade;Pharmaceutical Preparations;Pharmacotherapy;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;preclinical study;Proto-Oncogenes;PTEN gene;Radiation therapy;RB1 gene;RBL2 gene;Reagent;Recurrence;Relapse;replication stress;Resistance;response;RNA Polymerase II;Role;Signal Transduction;small cell lung carcinoma;STK11 gene;synergism;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapy resistant;Time;TP53 gene;transcription factor;transcriptome sequencing;Translating;translational therapeutics;Treatment outcome;treatment response;tumor;tumor growth;tumor progression;Tumor Subtype;Tumor Suppressor Genes;tumor-immune system interactions;Work

PROJECT_TITLE: Impact of recurrent genetic alterations on SCLC subtypes and therapeutic response


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE  High-fidelity cancer models that accurately reflect human small cell lung cancer biology play a key role in the development of new therapeutic strategies. The Model Generation and Therapeutic Analysis Core (Core B) for this Program will use CRISPR genome engineering technology to generate isogenic SCLC cell lines and somatically engineered mouse models, and streamline in vivo therapeutic analysis.

PROJECT_TERMS: Acceleration;Analytical Chemistry;anatomic imaging;animal imaging;Animal Model;Bioinformatics;biomarker discovery;Cancer Biology;Cancer Center;Cancer Etiology;cancer genomics;Cancer Model;cBioPortal;Cell Line;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;computing resources;Consumption;Credentialing;Data Analyses;Data Storage and Retrieval;design;Development;Disease;drug discovery;Drug Kinetics;Drug resistance;drug testing;Early treatment;Effectiveness;efficacy study;Engineering;Generations;Genes;Genetic Heterogeneity;Genetic Models;Genetic study;Genetically Engineered Mouse;Genome;Genome engineering;genomic data;genomic profiling;Genomics;Goals;Hand;Human;Human Cell Line;Human Engineering;In Vitro;in vivo;in vivo Model;Individual;Infrastructure;insight;Laboratories;Laboratory mice;loss of function;Malignant Neoplasms;Modeling;Molecular;Molecular Profiling;Monitor;Mouse Cell Line;mouse model;multiple data sources;Mus;Mutate;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Oncology;Pathogenesis;Pathology;patient derived xenograft model;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Pharmacy facility;Phenotype;Play;pre-clinical;preclinical development;preclinical study;programs;Proteins;Quality Control;replication stress;Research;Research Personnel;Research Project Grants;Resources;Role;Services;Shapes;small cell lung carcinoma;Standardization;Technology;Testing;Therapeutic;Time;Tissues;tool;Toxicology;Transgenic Organisms;treatment response;tumor;virtual;Xenograft Model

PROJECT_TITLE: SCLC Model Generation and Therapeutic Analysis


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases

PHR: The combination of modern microscopic and advanced computational methods can provide detailed insight into how DNA is repaired after damage. These insights can reveal vulnerabilities specific to cancer cells that can be used to develop more effective treatments.

PI_NAMEs: FENYO, DAVID  (contact)

PROJECT_TERMS: Algorithms;ATAC-seq;Binding Proteins;Biochemistry;Biotin;cancer cell;Cells;cellular engineering;Color;Communities;computer framework;computerized tools;Computing Methodologies;cost effective;Data;Data Analyses;data analysis pipeline;data dissemination;data integration;data modalities;Data Set;data visualization;Dedications;Development;Diffusion;DNA;DNA biosynthesis;DNA replication fork;DNA sequencing;Educational workshop;effective therapy;experimental study;feature extraction;Genes;Genetic Transcription;genome sequencing;Human Resources;Image;Image Analysis;imaging modality;Infrastructure;insight;Label;Learning;Lesion;Ligase;live cell imaging;Location;machine learning method;Mass Spectrum Analysis;Methods;Microscopic;Microscopy;Modeling;Modernization;Molecular;Molecular Biology;mouse model;multimodal data;mutant;Mutation;novel;novel therapeutics;Okazaki fragments;Online Systems;programs;Proteins;Proteomics;Protocols documentation;Quality Control;repaired;replication stress;Resistance;response;RNA;Role;self supervised learning;Signal Transduction;single molecule;small cell lung carcinoma;Standardization;Structure;superresolution imaging;superresolution microscopy;task analysis;Teaching Materials;therapy resistant;tool;Training;training opportunity;transcriptome;transcriptome sequencing;treatment response;Visualization software;whole genome

PROJECT_TITLE: Advanced Imaging and Computational Approaches


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  Hearing loss is commonplace: (1) 2-3 children out of every 1000 born in the USA have some form of hearing loss and (2) by the age of 75, over 50% of adults have disabling hearing loss. Language impairments, such as aphasia, also affect a significant number of Americans: 150,000+ each year. Thus, the proposed training program is extremely relevant to public health because it will help identify, motivate, and train the next generation of auditory and communication neuroscientists to exploit the explosion in computational and theoretical techniques from the very earliest stages of their scientific careers so that they can help lead the way to better diagnoses and treatments of a wide range of hearing and communication disorders.

PI_NAMEs: BALASUBRAMANIAN, VIJAY ;COHEN, YALE E (contact);GEFFEN, MARIA NEIMARK

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Communication;Neurosciences;Training

PROJECT_TITLE: Cross-disciplinary training in computational approaches to the neuroscience of audition and communication

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (11)]


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The competing renewal of the TGP training program is proposed to train the next generation of postgenome cancer researchers, including multidisciplinary training in: 1) translational cancer research, to gain exposure to mechanistic studies in translational research and their importance to the human organism; 2) precision medicine, to gain experience in state-of-the-art ways to diagnose and target treatment of cancer patients based on genomic profiles; 3) translational genetics and genomics, to gain competency in translational genomics needed for future understanding and implementation of cancer precision medicine; 4) bioinformatics, to learn how to read and interpret large genomics datasets; 5) exposure to relevant tumor boards and to industrial collaborations with academic faculty mentors on large scale genomic applications to cancer precision medicine. An outstanding training faculty has been assembled from the MD Anderson Cancer Center, the number one cancer center in the country, to provide state-of-the-art, inclusive education, training and mentoring for predoctoral and postdoctoral fellows to further the mission of MD Anderson to provide outstanding state-of-the- art research-driven patient care.

PI_NAMEs: SEN, SUBRATA  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Genomic medicine;Malignant Neoplasms;precision medicine;Training Programs;translational genomics

PROJECT_TITLE: Translational Genomics and Precision Medicine in Cancer Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (J1)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Training of the next generation of neuroscientists will have a long-term impact on a multitude of diseases of the nervous system as well as widely impacting the lives of countless individuals. Our Broad-based Research, Analytics, and Innovation in Neuroscience (B2RAIN) Predoctoral Training Program is designed to provide a group of innovative young scientists with rigorous state-of-the-art neuroscience training. In addition, the B2RAIN Training Program will provide participants with the quantitative tools and literacy necessary to tackle a wide range of future challenges in neuroscience research. Our program will be the only NIH Jointly Sponsored Ruth L. Kirschstein Institutional Predoctoral Training Program in the Neurosciences in the State of Florida.

PI_NAMEs: BIZON, JENNIFER LYNN (contact);CANDELARIO-JALIL, EDUARDO JESUS;GIASSON, BENOIT I

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TITLE: Broad-based Research, Analytics and Innovation in Neuroscience (B2RAIN) predoctoral Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (09)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: The Training Grant in Diabetes, Metabolism, and Endocrinology at the Vagelos College of Physicians & Surgeons, Columbia University, provides training in basic, translational, and clinical research to individuals with a background in biomedical research, holding MD and/or PhD degrees. The program aims to leverage the considerable human, scientific, and clinical resources of Columbia University to help trainees achieve academic distinction, establish themselves as leading investigators, and improve the practice of medicine.

PI_NAMEs: ACCILI, DOMENICO  (contact);PAJVANI, UTPAL

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: Training Grant in Diabetes and Endocrinology

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Cancer;Nanotechnology

ORG_CITY: BOSTON

ORG_DEPT: PHYSICS

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE CaNCURE: Cancer Nanomedicine Co-ops for Undergraduate Research Experiences The CaNCURE: Cancer Nanomedicine Co-ops for Undergraduate Research Experiences Program seeks to provide training and education in research at the interface of nanotechnology, cancer biology, and medicine to attract, retain, and encourage young scientists & engineers, particularly those from underrepresented minorities, to pursue careers in cancer research. The program will achieve this central aim by creating meaningful and rigorous research experiences mentored by outstanding academic and clinical researchers and supplemented with high-impact learning and professional development opportunities. The program combines Northeastern University's model of co-op education with the outstanding cancer nanomedicine research infrastructure at Dana-Farber/Harvard Cancer Center to create an immersive and inclusive training environment for knowledge and skills acquisition for the next generation of cancer researchers.

PI_NAMEs: SRIDHAR, SRINIVAS  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Active Learning;anti-cancer research;Award;Cancer Biology;Cancer Center;cancer health disparity;career;Career Choice;career preparation;Case Study;Clinical;Collaborations;college;Communication;Core Facility;Critical Thinking;cultural competence;data acquisition;Development;disadvantaged background;Disadvantaged minority;Education;educational atmosphere;Educational workshop;Engineering;Environment;evidence base;experience;Experimental Designs;faculty mentor;formative assessment;Funding;Goals;graduate school;hands on research;health care disparity;Healthcare;Immersion;Inequity;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Journals;Knowledge;Knowledge acquisition;Laboratories;Learning;Malignant Neoplasms;Manuscripts;medical schools;Medicine;Mentors;Mentorship;Modeling;Motivation;nanomedicine;Nanotechnology;next generation;Outcome;Patients;Peer Review;Persons;Population Scientist Supplement (R25);Preparation;Problem Solving;programs;Publishing;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resources;Scientist;skill acquisition;skills;skills training;STEM field;STEM student;student retention;Students;symposium;System;Traineeship;Training;Training Activity;Training and Education;Travel;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;volunteer


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: DENTISTRY

PHR: Project Narrative/Public Health Relevance Statement The heterogeneity of tumor microenvironment provides a unique physiological milieu for tumor progression and metastasis. The findings of this proposal will reveal a stromal progenitor cell hierarchy in squamous cell carcinoma to provide a foundation for cancer organoid culture, high-throughput screening, personalized medicine, and biomarker identification in head and neck cancer. The long-term goal of this proposal is to develop an applicable model to achieve the cure of cancer.

PI_NAMEs: CHEN, CHI-DER  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: 3-Dimensional;Animal Model;Area;biomarker identification;cancer cell;cancer initiation;cancer therapy;cancer type;Carcinoma;Cell Communication;Cell Physiology;Cell Proliferation;Cells;Characteristics;Chemotactic Factors;Clinical;Coculture Techniques;Complex;Computer Analysis;craniofacial;Data;Development;Dimensions;Diphtheria;Disease;Drug Screening;Epithelium;Erinaceidae;Face;Fibroblasts;Foundations;Gene Expression Profiling;Genetic;Goals;Growth;Harvest;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Heterogeneity;high throughput screening;Histopathology;Homeostasis;Human;Image;In Vitro;in vivo;Invaded;Keratinocyte tumor;Link;loss of function;Malignant Neoplasms;Mediating;Mesenchymal Stem Cells;microphysiology system;Modeling;Molecular;Molecular Analysis;Morphogenesis;Mus;Nature;Neoplasm Metastasis;Normal tissue morphology;novel;novel therapeutics;Oral;Organ;organ on a chip;Organoids;Pathway interactions;personalized medicine;Physiological;Play;Population;postnatal;Primary Neoplasm;Process;progenitor;Property;public health relevance;Recruitment Activity;Role;self assembly;Signal Transduction;single-cell RNA sequencing;Soil;Specimen;spheroids;Squamous cell carcinoma;stem;stem cell niche;stem cell population;stem cells;stromal progenitor;System;Techniques;three dimensional cell culture;Tissues;tool;transcriptome;transcriptomics;Translating;translational study;Transplantation;tumor;Tumor Cell Invasion;tumor heterogeneity;tumor initiation;tumor microenvironment;tumor progression;Tumor Tissue;Tumorigenicity;Validation;Vascularization

PROJECT_TITLE: Stromal Effects in Head and Neck Squamous Cell Carcinoma

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative The Genetic Dissection of Cells and Organisms Training Program (GDTP) training aims to enable diverse predoctoral students to acquire fundamental knowledge and skills required for ethical, impactful, rigorous, and reproducible research in genetics, as applied to basic biological processes and human health. The GDTP will prepare trainees to successfully pursue a variety of career paths that intersect with genetics. This integrative predoctoral genetics training program and the discoveries made by its trainees will contribute to the NIH’s mission to develop, maintain, and renew scientific human resources for the nation, fostering its capacity to enhance health, extend lives, and reduce disease burden.

PI_NAMEs: KING, NICOLE ;WHITEMAN, NOAH K (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: CHAPEL HILL

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The NICHD/NRSA-supported Population Science Research Training Program, housed at UNC’s Carolina Population Center, combines disciplinary PhDs with interdisciplinary predoctoral and postdoctoral training in demography and population science. Hallmarks of this longstanding program are: the integration of social and health sciences, an outstanding and experienced training faculty from 11 departments in the College of Arts & Sciences and the Gillings School of Global Public Health, the interdisciplinary team orientation of much of the training and research, and a well-established track record of success in the recruitment, training, and placement of trainees.

PI_NAMEs: FRANKENBERG, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Population Research;Research Training

PROJECT_TITLE: Population Research Training

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-R (90)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_DEPT: NEUROLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Inspiring Undergraduate Student Training in Alzheimer's Research (USTAR) is a 20-month undergraduate research educational program that will provide Black/African American undergraduate students with mentored didactic, clinical, and research experiences to stimulate interest in pursuing research careers related to Alzheimer's Disease and Related Dementias (ADRD). As an innovative, highly structured, and supportive research education program, USTAR has potential to increase diversity in the national workforce that conducts health disparities research pertaining to ADRD. This goal aligns with the NIA mission to meet the nation's biomedical, behavioral, and clinical research needs and to ensure health equity for all Americans.

PI_NAMEs: LAWAL, HAKEEM O;PARKS, SUSAN MOCKUS;ROVNER, BARRY W. (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Address;Advocate;Affect;African American;African American student;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Area;base;Basic Science;Behavior;behavioral health;Behavioral Research;Biomedical Research;Black race;career;Caring;Clinical;clinical care;Clinical Research;Cognition;cohort;Collaborations;Communities;Competence;Consult;Data;Delaware;deprivation;Development Plans;Diabetes Mellitus;Diet;Disparity;Education;education research;Educational Activities;effectiveness research;Ensure;Environmental Risk Factor;experience;Faculty;faculty mentor;Future;Geriatrics;Goals;Health Disparities Research;health disparity;health equity;Health Services Accessibility;Healthcare Systems;Historically Black Colleges and Universities;Individual;innovation;interest;K-Series Research Career Programs;Knowledge;Learning;lectures;Life Style;Longitudinal, observational study;Medical;medical schools;Mentors;Mentorship;mild cognitive impairment;Mission;Modeling;Nature;Neighborhoods;neuroimaging;neuropathology;Neuropsychology;Neurosciences;Neurosciences Research;Nursing Faculty;older adult;Participant;Patients;Philadelphia;Physical activity;programs;Public Health;Publications;Race;racial disparity;racial diversity;racial health disparity;recruit;Research;Research Activity;research faculty;Research Personnel;Research Project Grants;Research Training;Risk;Sampling;Science;Scientist;Self Efficacy;skill acquisition;skills;skills training;social culture;social determinants;social factors;social health determinants;Structure;student training;Students;summer internship;summer program;telehealth;tool;Training;Training Programs;Translational Research;Trust;undergraduate research;undergraduate student;Universities;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (J2)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Mental Health;Neurosciences;Pain Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health;Women's Health Research

ORG_CITY: BIDDEFORD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEW ENGLAND

ORG_STATE: ME

PHR: Although it is now clear in human neonatal intensive care unit (NICU) patients that sex differences exist in the effects of early life pain and stress on later psychological functioning and chronic pain, the mechanisms underlying these effects remain unclear. This project investigates the behavioral and neuroendocrine changes that occur in a rodent NICU model of neonatal pain and stress in both male and female rats, testing the hypothesis that there will be sex differences in the underlying mechanisms.

PI_NAMEs: BURMAN, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Absence of pain sensation;Adolescent;Adult;Affect;Affective;age difference;age related changes;Amygdaloid structure;antagonist;antinociception;Anxiety;anxiety-like behavior;arm;arthritic pain;Behavior;Behavioral;behavioral response;Biological;biological adaptation to stress;Biological Markers;Brain;brain circuitry;Cell Nucleus;cell type;Cells;chronic pain;Complex;conditioned fear;conditioning;Corticosterone;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;Data;design;Development;Disease;Down-Regulation;Dynorphins;early adolescence;early life adversity;early life stress;Early-life trauma;Emotional;Endocrine;experience;experimental study;Exposure to;Female;Freezing;Fright;Functional disorder;Gene Expression;Genes;Goals;Growth;Human;Hypersensitivity;Hypothalamic structure;Immediate-Early Genes;Immunohistochemistry;In Situ Hybridization;Individual;Infant;innovation;Intervention;Knowledge;late life;Life;life span;Literature;male;maternal separation;Medical;Mental Depression;midbrain central gray substance;Modeling;Moods;mortality;Mus;Nature;Needles;negative affect;Neonatal;neonatal exposure;neonatal human;Neonatal Intensive Care Units;Neurobiology;Neurologic;Neurologic Dysfunctions;Neurons;Neuropeptide Gene;Neuropeptides;Neurosecretory Systems;Nociception;Outcome;Output;Pain;Pain Measurement;Pain Threshold;painful neuropathy;Patients;Pattern;Persistent pain;Phenotype;Physiological;Pituitary-Adrenal System;Play;Population;postnatal;pre-clinical;Predisposition;Proxy;psychologic;Psychological Stress;psychological stressor;Rattus;Recording of previous events;response;Risk;Risk Factors;Rodent;Role;Sensory;Series;sex;Sex Differences;Signal Transduction;Somatostatin;Source;Stimulus;Stress;stressor;System;Testing;Trauma;Work

PROJECT_TITLE: Ontogeny of sex differences in amygdala and hypothalamus after neonatal trauma

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-W (SU)]


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: The University of Virginia School of Data Science and Center for Public Health Genomics will collaborate to train 45 Masters-level genomics data scientists, through both classroom and research experiences. UVA’s Masters in Data Science (MSDS) program is ideally suited to this effort because it affords 1) a year-long capstone experience, 2) space for elective courses which allow students to acquire vital genomics content knowledge alongside their data science curriculum, and 3) an emphasis on responsible data science and research ethics that is crucial to training of the biomedical and informatics workforce. Robust supports for student recruitment and mature relationships with minority-serving institutions (MSIs) will ensure that the students trained in genomics data science represent the diversity of the patients that will be impacted by their work.

PI_NAMEs: BROWN, DONALD E (contact);ZANG, CHONGZHI

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Accountability;Area;Awareness;Behavioral Sciences;Bioinformatics;Biological Sciences;career;Career Choice;Clinical Sciences;cohort;Collaborations;Computational Biology;computer science;Data;data centers;Data Science;Data Scientist;design;Education;Educational Curriculum;Educational Materials;Educational process of instructing;Educational workshop;Engineering;Ensure;Ethics;Event;Exercise;experience;flexibility;Foundations;Gender;Genetic;genomic data;Genomics;hackathon;Informatics;innovation;interest;Knowledge;Laboratories;Laboratory Research;learning strategy;Link;medical schools;Methodology;Methods;microbiome;Minority Groups;minority student;Minority-Serving Institution;Modification;Outcome;parity;Participant;Patients;Persons;precision medicine;Privacy;Problem Solving;programs;prospective;Public Health;Recording of previous events;recruit;Recruitment Activity;Research;Research Ethics;Research Personnel;Schools;Science;Security;skills;statistics;Student recruitment;student training;Students;symposium;System;Teaching Materials;Techniques;Training;undergraduate student;Underrepresented Populations;Universities;Virginia;virtual;Vision;webinar;Woman;Work

PROJECT_TITLE: Research Experiences in Genomic Applications of Responsible Data Science (REGARDS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (J1)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Musculoskeletal diseases affect about one-third of the U.S. population. The estimated total cost of this disease burden in the U.S. is approximately 5.2% of the country’s gross domestic product. We propose to improve the research infrastructure by training predoctoral students and postdoctoral fellows with the long-term goal of decreasing this societal burden through creation of a workforce that is adept at acquisition and application of new knowledge.

PI_NAMEs: SUMNER, D RICK (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Pre and Post-Doctoral Training in Joint Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cannabinoid Research;Hematology;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Public Health Relevance Statement Superwarfarins are long-acting 4-hydroxycoumarin derivative anticoagulants developed and widely used for pest control, but their availability and affordability have led to both accidental and intentional poisonings. The only existing treatments are vitamin K and infusion of plasma coagulation factors which are expensive, have limited accessibility, and may be required for months or years. The proposed studies will develop new therapeutics in a high-throughput, tractable model system that are desperately needed to treat affected patients.

PI_NAMEs: SHAVIT, JORDAN A (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Accidents;Acute;Adult;Affect;antagonist;Anticoagulants;Antidotes;Area;Biological Models;Biological Process;biological systems;Blood coagulation;Blood Coagulation Disorders;Blood Coagulation Factor;blood product;Blood Vessels;Cannabinoids;Cardiovascular system;Cell Line;Cells;Cessation of life;Childhood;Coagulation Process;Complex;Custom;Dangerousness;Data;Development;drug repurposing;Embryo;Endothelium;Enzymes;Estrogens;Evaluation;Event;FDA approved;Fertilization;Fingerprint;genome editing;Goals;Half-Life;Health;Hemorrhage;Hemostatic function;Hospitalization;Hour;Human;improved;in silico;in vivo Model;Individual;Infusion procedures;Injury;innovation;innovative technologies;Intravenous infusion procedures;Larva;Lead;Libraries;Life;Liver;Mammals;mass casualty;medical countermeasure;Minor;Modeling;Modification;Molecular;Molecular Target;Morbidity - disease rate;mortality;novel;novel therapeutics;offspring;Optics;Oral;Overdose;Patients;Pest Control;Pharmaceutical Preparations;Phenotype;Plasma;Play;prevent;Process;public health relevance;Recombinants;Recycling;Research;Resistance;response;Risk;Rodent;Rodenticides;Role;small molecule;small molecule libraries;Suicide attempt;System;Time;Toxic effect;Vascular Endothelium;Visualization;Vitamin K;vitamin K epoxide reductase;Warfarin;Whole Organism;Work;Zebrafish

PROJECT_TITLE: Development of novel anticoagulant antidotes using zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-F (54)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

PHR: Project Narrative The Neural Systems and Behavior Course (NS&B) provides an exceptional and singular training opportunity that enables the next generation of researchers to tackle the problems central to issues of mental illness. This 8- week course is characterized by a rigorous and innovative curriculum that is focused on discovery research and integrates across diverse levels of biological organization thus leading the alumni and faculty to a better understanding of the human brain and the truly complex causes of mental illness. Since its inception in 1978, NS&B has prepared students to understand how the brain generates behavior by using unique and complementary inquiry-based laboratory exercises to teach experimental techniques, concepts and experimental design at the cutting edge of systems neuroscience.

PI_NAMEs: HYMAN, LINDA E (contact);PEREDA, ALBERTO E;WHITE, STEPHANIE ANN

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Animal Behavior;Animal Model;Basic Science;Behavior;Behavioral;Behavioral Mechanisms;Biological;Biological Models;Birds;Brain;brain behavior;career development;Cells;Cognition;Communities;Complex;computational neuroscience;Computer Models;computer science;COVID-19 pandemic;Creativeness;Crustacea;Data;Data Analyses;design;Development;Discipline;Disease;diversity and inclusion;doctoral student;Education;educational atmosphere;Educational Curriculum;Educational process of instructing;Electrophysiology (science);Engineering;Equipment;Ethics;Exercise;experience;Experimental Designs;experimental study;Exposure to;extracellular;Faculty;Fishes;forging;Fostering;Foundations;Funding;gene editing technology;Gene Expression Profiling;gene network;Genes;genetic manipulation;Goals;high reward;Human;Image;imaging approach;in vivo;innovation;Insecta;Institution;International;Investigation;Laboratories;laboratory experience;laboratory experiment;laboratory module;Learning;lectures;Left;Life Change Events;Mammals;marine;Mathematics;member;Memory;Mental disorders;Mental Health;Mental Processes;Methodology;Molecular;Molecular Analysis;Molecular Genetics;multilevel analysis;National Institute of Mental Health;Nervous System Disorder;neural;neural circuit;Neurobiology;neurogenomics;neuromechanism;Neurons;Neurophysiology - biologic function;Neurosciences;Neurosciences Research;next generation;Organism;outreach;Participant;patch clamp;Pathologic;Physics;Preparation;programs;Psychology;Reproducibility;Research;Research Personnel;Research Project Grants;Research Training;Science;Scientist;signal processing;skills;Social Behavior;social neuroscience;Solid;statistics;Strategic Planning;Structure;student training;Students;supportive environment;System;Talents;teacher;Techniques;Time;Training;training opportunity;translational neuroscience;translational potential;visiting scholar;Whole Organism;Work

PROJECT_TITLE: Neural Systems and Behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (01)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: The purpose of this renewal application is to continue a translational and interdisciplinary training program in alcohol research. This multidisciplinary program provides training in bio-behavioral factors associated within alcohol-use disorders at the pre-doctoral level; graduates of this program are actively involved in research, teaching, publishing articles, and becoming independent researchers in the alcohol field. We aim to advance our program of excellence in translational or interdisciplinary research training because the need for a translational or interdisciplinary program is greater today than ever before, and the proposed continuation of this training program fills a unique niche in alcohol research.

PI_NAMEs: FILLMORE, MARK T (contact);PRENDERGAST, MARK A

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: alcohol research;Training

PROJECT_TITLE: Interdisciplinary Training in Alcohol Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 CC (32)]


ORG_CITY: COLLEGE STATION

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Investigating the role of Ikaros variant in multiple myeloma pathophysiology and drug sensitivity This study will advance our knowledge about the drivers, resistance, and sensitivity pathways of multiple myeloma. It has the potential to identify novel prognostic marker for multiple myeloma treatment and response.

PI_NAMEs: SINGH, IRTISHA  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: 3' Untranslated Regions;Allografting;Alternative Splicing;Binding;Biogenesis;Bone Marrow;Cell Count;cell growth;Cells;Chromatin;chromatin remodeling;Code;Complex;Data;Degradation Pathway;Dependence;design;Development;Disease;Disease Management;DNA;DNA Binding;drug sensitivity;Epigenetic Process;Exhibits;Exons;Feedback;Functional disorder;gain of function;Gene Targeting;Genes;Genetic Transcription;genome-wide;Growth;Heterodimerization;Homo;Impairment;improved;in vivo;insight;Introns;Investigation;Knowledge;lenalidomide;Length;loss of function;Lymphocyte;Lymphoid;Malignant - descriptor;Malignant Neoplasms;Molecular;Morbidity - disease rate;Multiple Myeloma;novel;Oncogenic;Organ;Pathogenesis;Pathway interactions;Patients;Plasma Cells;Polyadenylation;preference;Prognostic Marker;programs;Progression-Free Survivals;Proliferating;Protein Isoforms;Publishing;Relapse;Resistance;response;RNA 3' End Processing;Role;Shapes;Thalidomide;therapeutic target;therapy development;transcription factor;tumor;tumor growth;tumorigenic;ubiquitin ligase;Ubiquitination;Variant

PROJECT_TITLE: Investigating the role Ikaros variants in multiple myeloma pathophysiology and drug sensitivity

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: DALLAS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE The goal of the Resource for Molecular Imaging Agents in Precision Medicine is to provide new, precision materials, to test these pre-clinically and progress them to human use, delivered on-site or to our collaborators in a format suitable for their implementation. While focusing on the biological theme of relationships between cancer, inflammation and immunity, we will be nimble and flexible, developing a wide variety of small molecules and macromolecular agents in collaboration with other academic centers and industry worldwide.

PI_NAMEs: POMPER, MARTIN G (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Address;Affinity;analog;Animal Model;Artificial Intelligence;Biochemistry;Biological;Biomedical Engineering;biomedical imaging;Biomedical Research;Cell model;Cells;Central Nervous System;Chemicals;Clinical;clinical translation;Collaborations;commercialization;Comprehensive Cancer Center;Computer software;Cyclic GMP;Dedications;Detection;Development;Disease;Early Diagnosis;Ecosystem;Ensure;Entrepreneurship;Environment;Equipment;extracellular vesicles;flexibility;Functional disorder;Funding;genetic manipulation;Goals;Healthcare;Human;Image;image translation;imaging agent;Imaging Device;Immune;Immunity;immunoengineering;improved;Industrialization;Industry;industry partner;Inflammation;Institution;instrumentation;Intercept;Malignant neoplasm of pancreas;Malignant Neoplasms;Manufacturer;Medical;Methods;Molecular;molecular imaging;monocyte;nanoparticle;Nanotechnology;nanotechnology platform;nanotheranostics;Nervous System;neuroinflammation;neuropsychiatry;next generation;Outcome;Participant;Pathway interactions;Patients;Pharmacologic Substance;Positron-Emission Tomography;pre-clinical;Precision Health;precision medicine;Preclinical Testing;Process;prognostication;programs;radiochemical;Radiology Specialty;radiotracer;Reagent;Recording of previous events;Research;Research Personnel;Resources;scaffold;scale up;Science;Services;Site;small molecule;Speed;Techniques;Technology;theranostics;Therapeutic;Thinking;tool;Training;Training Programs;Transgenic Animals;Translating;Translations;tumor microenvironment;tumor-immune system interactions;Universities;Validation;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-E (J1)]


PROJECT_TERMS: Advisory Committees;Advocate;Animal Care and Use Committees;Animals;Appointment;Basic Science;Biological;Clinical Medicine;Clinical Research;cohesion;Collaborations;Comprehensive Cancer Center;Dedications;Development;Discipline of Nuclear Medicine;Engineering;Environment;experience;Extramural Activities;Financial Activity;Financial Support;Funding;Guidelines;Human;imaging agent;Immunity;Immunology;Inflammation;Institution;Institutional Review Boards;Letters;Maintenance;Malignant Neoplasms;Medical;medical schools;meetings;member;Methods;Modality;molecular imaging;Monitor;National Institute of Biomedical Imaging and Bioengineering;nuclear division;operation;organizational structure;Patients;precision medicine;Productivity;programs;Progress Reports;Protocols documentation;Radiology Specialty;Radiopharmaceuticals;Research;Research Personnel;Resources;Running;Schools;scientific organization;Services;Training;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Administration-Resource for Molecular Imaging Agents in Precision Medicine


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Pancreatic Cancer;Precision Medicine;Rare Diseases;Women's Health Research

PI_NAMEs: BHUJWALLA, ZAVER M. (contact)

PROJECT_TERMS: 4T1;Acceleration;Aftercare;Binding;Biological Markers;Biopsy;Breast;Breast Cancer Model;cancer cell;cancer immunotherapy;Cancer Model;cell killing;Chemicals;Chemistry;Chronic Disease;Circulation;Clinical;Collagen;Complex;decorin;design;Development;Disease;Down-Regulation;Engineering;Environment;ex vivo imaging;Exhibits;Extracellular Matrix;Extracellular Matrix Proteins;Faculty;Fibrosis;Funding;Goals;Heterogeneity;Hypoxia;hypoxia inducible factor 1;Image;imaging agent;imaging modality;imaging probe;Immune;immune cell infiltrate;immune checkpoint;Immune checkpoint inhibitor;Immunocompetent;improved outcome;in vivo;Inbred BALB C Mice;Inflammation;KPC model;Label;liposomal formulation;Liposomes;Luciferases;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;mass spectrometric imaging;Modeling;molecular imaging;multidisciplinary;Multimodal Imaging;Mus;Myeloid-derived suppressor cells;nanoparticle;nanoparticle delivery;non-invasive imaging;novel;optical imaging;overexpression;Pancreas;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;Patients;PD-1/PD-L1;Peptides;Positron-Emission Tomography;pre-clinical;precision medicine;predicting response;programmed cell death ligand 1;programmed cell death protein 1;radiotracer;Reagent;Reporter;Reporting;Research;Resistance;Resources;response;Response Elements;Services;Signal Transduction;siRNA delivery;Site;Small Interfering RNA;spatiotemporal;Spleen;success;synergism;Technology;theranostics;Time;Treatment outcome;triple-negative invasive breast carcinoma;tumor;tumor hypoxia;tumor microenvironment;Tumor Oxygenation;Validation

PROJECT_TITLE: Imaging and theranostics to detect and promote an immune reactive tumor microenvironment


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Nanotechnology;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases;Skin Cancer

PROJECT_TERMS: Address;Affinity;antifibrotic treatment;cancer cell;Carcinoma;Cell surface;Collaborations;Colorectal;cytokine;Cytotoxic T-Lymphocytes;Data;Dedications;design;Desmoplastic;Development;Distant Metastasis;Drug Kinetics;Elements;Engineering;Esters;experience;extracellular;fibroblast-activating factor;Fibroblasts;Firefly Luciferases;FOLH1 gene;Genetically Engineered Mouse;Glioblastoma;Goals;Homing;Hybrids;Image;imaging agent;imaging modality;In Situ;in vitro testing;in vivo;in vivo Model;Inflammatory;Injections;Interleukin-12;KPC model;Lesion;Localized Disease;Malignant Neoplasms;Melanoma;Molecular;Molecular Genetics;molecular imaging;Mucinous;multimodality;nanomedicine;nanoparticle;Nanotechnology;Nucleic Acids;Organoids;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;particle;Pharmaceutical Preparations;pharmacophore;Phenotype;Plasmids;Polymers;pre-clinical;Pre-Clinical Model;precision medicine;programs;promoter;Property;Protocols documentation;Radiation therapy;Reagent;Reporter;Resources;Silicon Dioxide;small molecule;Specificity;Structure;Surface;T cell infiltration;targeted treatment;Technology;technology platform;Testing;theranostics;Therapeutic;Therapeutic Agents;tumor;tumor eradication;tumor microenvironment;tumor-immune system interactions;Validation

PROJECT_TITLE: Targeted nanotechnology for the pancreatic tumor immune microenvironment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Cancer;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Therapeutics and Interventions;Dementia;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Precision Medicine;Radiation Oncology

PI_NAMEs: RAY, SANGEETA  (contact)

PROJECT_TERMS: adaptive immune response;Address;Adverse effects;Alzheimer's Disease;Antibody-drug conjugates;Appearance;Artificial Intelligence;Baltimore;cancer imaging;Catchment Area;cell type;Cells;Central Nervous System;chimeric antigen receptor T cells;Clear cell renal cell carcinoma;Clinical;Collaborations;combat;Communicable Diseases;COVID-19;Data;Dementia;design;Disease;Disparate;Dose;Elements;Epoxide hydrolase;Equilibrium;fibroblast-activating factor;Fibroblasts;fighting;FOLH1 gene;Functional disorder;Future;Health protection;HIV-associated cognitive impairment;Image;imaging agent;Imaging Device;Immune checkpoint inhibitor;Immunotherapeutic agent;Impaired cognition;Industry;Infection;Inflammation;Injury;Innate Immune Response;Label;Libraries;Licensing;Long COVID;Macrophage Colony-Stimulating Factor;Macrophage Colony-Stimulating Factor Receptor;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;molecular imaging;neovasculature;Nervous System Disorder;neuroinflammation;Neurologic;neuropsychiatric disorder;novel therapeutics;Parkinson Disease;patient prognosis;Patient Selection;Patients;Peripheral;Phase;Play;Population;Pre-Clinical Model;precision medicine;Process;Prognosis;programs;Radiation therapy;Radiopharmaceuticals;Reagent;Regimen;Resources;Role;Series;Services;Site;Specificity;synergism;targeted agent;Testing;theranostics;therapeutic target;tool;Training;Translations;Traumatic Brain Injury;tumor;tumor microenvironment;tumorigenesis;Vaccines;Validation;web site;Work

PROJECT_TITLE: New tools for imaging and theranostics in inflammation and cancer


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Multiple Sclerosis;Nanotechnology;Neurodegenerative;Neurosciences;Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: BULTE, JEFF W. (contact)

PROJECT_TERMS: Amyotrophic Lateral Sclerosis;Apoptotic;Area;Behavioral;Biodistribution;bioluminescence imaging;Bone Marrow;Cell Survival;Cell Therapy;cell type;Cells;chelation;Chemicals;Clinical;clinical translation;Clinical Trials;Communities;Complex;contrast imaging;Contrast Media;cost;Degenerative polyarthritis;Diabetes Mellitus;Diagnostic;Disease;Electroporation;Ethics;Experimental Autoimmune Encephalomyelitis;extracellular vesicles;Face;Formulation;Freezing;Future;Gadolinium;Germ Cells;Goals;Half-Life;Homing;Image;imaging agent;immunoregulation;Immunosuppression;improved;in vivo;in vivo imaging;Inflammation;Inflammatory;interest;iron oxide;Label;Link;Lipids;lipophilicity;Logistics;Luciferases;Macrophage;Magnetic Resonance Imaging;Magnetism;Malignant Neoplasms;Mannose;Medicine;Membrane;Mesenchymal Stem Cells;Methods;Modality;molecular imaging;mouse model;Multiple Sclerosis;multiple sclerosis patient;Multipotent Stem Cells;Myocardial Ischemia;nanoGold;nanotheranostics;Nervous System Disorder;neuroinflammation;neuroprotection;Outcome Measure;overexpression;Oxyquinoline;particle;Phase;Photons;Pluripotent Stem Cells;Polysaccharides;Positron-Emission Tomography;Pre-Clinical Model;precision medicine;Preparation;Primary Lateral Sclerosis;Production;Property;radiotracer;Reporter Genes;Research Personnel;Resources;Route;Safety;Signal Transduction;Site;Specificity;stem cell therapy;stem cells;Stroke;Stromal Cells;Superoxide Dismutase;superparamagnetism;Techniques;Testing;Therapeutic;Therapeutic Agents;therapy outcome;Tissues;tomography;Tracer;Transgenic Mice;Transgenic Organisms;tumorigenic;Uncertainty;Validation;validation studies;Vesicle;X-Ray Computed Tomography

PROJECT_TITLE: Extracellular vesicles as nanotheranostic platform in neuroinflammation


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

PI_NAMEs: SOLNES, LILJA  (contact)

PROJECT_TERMS: Algorithms;Allied Health Sciences;Ally;American Association of Cancer Research;Area;Artificial Intelligence;Biological Psychiatry;Biomedical Engineering;Book Chapters;Brain Mapping;cancer imaging;Central Nervous System Diseases;Clinical;clinical translation;Collaborations;Communities;Computer software;continuing medical education;COVID-19 pandemic;data sharing;Dedications;Development;Discipline of Nuclear Medicine;diverse data;drug development;Education;Educational Activities;Educational workshop;Ensure;Entrepreneurship;Equipment;Event;experimental study;Faculty;Funding;Goals;Health system;high school;Historically Black Colleges and Universities;Hour;Human;Image;Image Analysis;imaging agent;Immunity;implementation tool;Individual;Industry;industry partner;Inflammation;Informatics;innovation;inter-institutional;interest;Internet;Journals;Laboratories;Learning;lectures;Licensing;Link;Malignant Neoplasms;Manufacturer;material transfer agreement;Medical;Medical Research;medical schools;meetings;member;Methods;molecular imaging;nanomedicine;nuclear division;Pathway interactions;Patients;Peer Review;Persons;Postdoctoral Fellow;precision medicine;programs;Protocols documentation;Publications;Reagent;recruit;Research;Research Personnel;Resources;sabbatical;Services;Site;social media;Societies;STEM field;Students;symposium;Techniques;Technology;technology development;theranostics;tool;Training;Training and Education;training data;Translations;Universities;Update;Validation;Visit;visiting scholar;Washington;web site;webinar;Work

PROJECT_TITLE: Training/Dissemination-Resource for Molecular Imaging Agents in Precision Medicine


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE This is an interdisciplinary predoctoral program in computational cognitive neuroscience. Funds from this program will support the training of advanced predoctoral candidates who are capable of applying a combination of empirical and theoretical approaches that decisively addresses their scientific questions about the mind and brain. Training a generation of such scientists holds great promise for making transformative gains in our understanding of mental health and brain diseases and disorders.

PI_NAMEs: BADRE, DAVID ;FRANK, MICHAEL J. (contact);JONES, STEPHANIE RUGGIANO;MOORE, CHRISTOPHER I

PROJECT_TITLE: Training Program for Interactionist Cognitive Neuroscience (ICoN)

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (01)]


ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The Georgetown Lombardi Comprehensive Cancer Center (LCCC) is applying for this renewal of its CCSG as a consortium cancer center with the John Theurer Cancer Center of Hackensack Meridian Health. LCCC’s vision is to impact our diverse catchment area, the nation, and beyond by pushing scientific knowledge, creativity, and application; serving all with compassion, equity and respect; and preparing individuals who will devote themselves to reducing the severity of cancer on the individual, family, and community through improved access to care. LCCC remains the only NCI-designated comprehensive cancer center based in the nation's capital.

PI_NAMEs: WEINER, LOUIS M. (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Academic Medical Centers;Address;anti-cancer research;Black race;Cancer Burden;cancer care;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Family;cancer health disparity;cancer immunotherapy;cancer prevention;cancer risk;Capital;Caring;Catchment Area;Cellular biology;Clinical;clinical care;clinical epidemiology;Clinical Research;Clinical Sciences;Clinical Treatment;Clinical Trials;Communities;community engagement;Community Outreach;Compassion;Comprehensive Cancer Center;County;COVID-19 pandemic effects;Creativeness;Data;Development;Disadvantaged;Disparity;disparity elimination;District of Columbia;Educational process of instructing;Enrollment;Ensure;Equity;equity, diversity, and inclusion;Family;Fox Chase Cancer Center;Funding;Future;global health;Goals;Growth;Health;health disparity;Health Personnel;Health Promotion;Health Services Accessibility;Hispanic;Immunooncology;Improve Access;improved;Individual;Institution;interdisciplinary collaboration;Intervention;Intervention Trial;Investigational Therapies;investigator-initiated trial;Investments;Justice;Knowledge;Latinx;Laws;Leadership;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Marketing;Maryland;Medical Oncologist;member;Meridians;Methods;Mid-Atlantic Region;Mission;Modeling;National Cancer Institute;New Jersey;Outcome;Paper;Patients;Peer Review;Persons;Policies;Population;pre-clinical;prevent;Professional counselor;programs;Public Policy;Publishing;Recovery;recruit;Research;Research Personnel;Resource Sharing;Resources;Scientific Advances and Accomplishments;Services;Severities;Source;Strategic Planning;Structure;Therapeutic Intervention;Thinking;Training;Training and Education;translational scientist;Translations;Trust;underserved community;Underserved Population;United States National Institutes of Health;Universities;Virginia;Vision;Washington

PROJECT_TITLE: Georgetown University Lombardi Comprehensive Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: LEVY, SHARON GAIL (contact)

PROJECT_TERMS: Academic Medical Centers;Achievement;Administrator;anti-cancer research;Appointment;Automobile Driving;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;career development;Catchment Area;Clinical;Clinical Data;Clinical Protocols;Clinical Research;Communication;community engagement;Community Outreach;Comprehensive Cancer Center;Contracts;dashboard;data management;Databases;Decision Making;Development;Ensure;Equity;equity, diversity, and inclusion;Evaluation;experience;Faculty;Fostering;Funding;Goals;Grant;Group Meetings;Health;Human Resources;Information Technology;Infrastructure;innovation;Institution;Investments;Leadership;Malignant Neoplasms;Marketing;member;Meridians;Monitor;Office Management;operation;Operations Research;Parents;Peer Review;population based;Process;programs;recruit;Reporting;Research;research and development;Research Infrastructure;Resource Allocation;Resource Sharing;Role;satisfaction;Science;Services;Site;Strategic Planning;Technology;Time;Training and Education;trend;Universities;Vision;Washington;Work;working group

PROJECT_TITLE: Cancer Center Administration


PI_NAMEs: RIGGINS, REBECCA B (contact)

PROJECT_TERMS: Active Learning;Administrator;American Cancer Society;anti-cancer research;Award;cancer cell;Cancer Center Support Grant;career;career development;Catchment Area;Cellular biology;Clinical;Clinical Investigator;Clinical Research;cohort;community collaboration;community engagement;Community Outreach;Comprehensive Cancer Center;continuing medical education;Development;Development Plans;Direct Costs;Doctor of Philosophy;doctoral student;early-career faculty;Education;Educational Curriculum;Educational workshop;elementary school;Eligibility Determination;Employment;Environment;equity, diversity, and inclusion;ethnic diversity;Event;evidence base;experience;Faculty;faculty mentor;Fellowship;Fellowship Program;Fostering;Funding;Funding Applicant;Future;Goals;graduate student;Grant;high school;Hour;Individual;innovation;Internships;K-12 student;K-Series Research Career Programs;Laboratory Research;Malignant Neoplasms;Medical;Medical Students;member;Mentors;mid-career faculty;minority undergraduate;multidisciplinary;National Research Service Awards;NCI Center for Cancer Research;next generation;Oncology;Participant;Peer Review;pharmacologic;Phase;Physicians;Population Sciences;Postdoctoral Fellow;Process;Program Development;programs;racial diversity;Recommendation;recruit;Research;Research Personnel;Research Training;Scholars Program;Science;Scientist;Series;Structure;Students;summer research;Training;Training and Education;Training Programs;Tumor Biology;undergraduate student;Underrepresented Minority;Universities;Writing

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GRAVES, KRISTI D. (contact)

PROJECT_TERMS: Academic Medical Centers;Achievement;Affinity;Alaskan;American Indians;anti-cancer research;anti-racism;Association of American Medical Colleges;Attention;Award;Black race;Cancer Center;Cancer Center Support Grant;career;Characteristics;Collaborations;community engagement;Community Outreach;Comprehensive Cancer Center;cultural equity;Data;demographics;Development;Disabled Persons;disadvantaged background;Discipline;Disparity population;Doctor of Philosophy;Equity;equity, diversity, and inclusion;Ethnic Origin;experience;Feeling;Fellowship Program;Fostering;Funding;Gender;Gender Identity;Goals;Health;Hispanic;improved;Individual;Infrastructure;instructor;Latinx;Leadership;leadership development;member;Mentors;Meridians;Methods;mid-career faculty;Native Hawaiian or Other Pacific Islander;Patient Self-Report;Peer Group;Persons;Policies;professor;programs;Race;Recording of previous events;recruit;Reporting;Research;Research Support;Science;senior faculty;Sex Orientation;Social Justice;Students;Talents;Training;Training and Education;trait;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;Vision;Woman;Work

PROJECT_TITLE: Plan to Enhance Diversity


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

PI_NAMEs: SLINGERLAND, JOYCE MARIE (contact)

PROJECT_TERMS: Address;Adipocytes;anti-cancer;anti-cancer research;anti-cancer treatment;Antigen-Presenting Cells;Antimicrobial Resistance;Basic Science;Breast;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Etiology;cancer immunotherapy;cancer therapy;carcinogenesis;career;Catchment Area;CCKBR gene;Cell Communication;Cell Therapy;Cells;chimeric antigen receptor;Cholecystokinin B Receptor;Clinic;Clinical Cancer Center;Clinical Data;Clinical Investigator;Clinical Protocols;Clinical Research;Collaborations;Communication;Communities;community collaboration;community engagement;Community Outreach;Comprehensive Cancer Center;cytokine;data management;Development;Diabetes Mellitus;Disease;Doctor of Philosophy;Drug resistance;Educational workshop;effective therapy;Endothelial Cells;Environment;environment related cancer;Epigenetic Process;estrogenic;Estrone;Faculty;Fibroblasts;Fibrosis;Fostering;Funding;Future;Gene Modified;gene therapy;Genetic Transcription;Goals;Grant;Group Meetings;Health;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Hormonal;hormone therapy;Immune;immune cell infiltrate;Immune Evasion;Immunity;Immunologic Surveillance;Immunotherapy;improved;Inflammatory;insight;Integration Host Factors;Investigational Therapies;investigator-initiated trial;Journals;Laboratories;Link;Lung;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mediating;Mediator;meetings;member;Memory;Mentors;Meridians;Metabolic;Microbe;microbial host;microbiome research;Mission;Mitochondria;Natural Killer Cells;NCI-Designated Cancer Center;Neoplasm Metastasis;next generation;novel;novel therapeutics;Obesity;Outcome;Pancreatic Adenocarcinoma;pathogenic microbe;Patient Care;Patients;Peer Review;phase II trial;Physicians;Pilot Projects;prevent;Process;professor;programs;Publications;Recording of previous events;recruit;Regulation;Research;Research Personnel;Research Support;Resistance;Resource Sharing;Resources;Role;Science;Scientist;Signal Transduction;Source;stem cells;Strategic Planning;success;T memory cell;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Trials;therapy outcome;Tissues;Training;Training and Education;Translating;translational scientist;Translations;tumor;Tumor Immunity;tumor microenvironment;tumor progression;tumorigenesis;United States National Institutes of Health;Universities;working group

PROJECT_TITLE: Cancer Host Interactions Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health;Tobacco

PI_NAMEs: ROZEK, LAURA  (contact)

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Applications Grants;Area;Attention;Automobile Driving;base;Behavioral;biobehavior;Biological Markers;Cancer Burden;cancer care;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer health disparity;Cancer Intervention and Surveillance Modeling Network;cancer prevention;cancer risk;cancer-related cognitive impairment;care delivery;career;Catchment Area;Cellular biology;Climate;Clinical;Clinical Sciences;Collaborations;Communication;Communities;Community Clinical Oncology Program;community engagement;Community Outreach;Comprehensive Cancer Center;Discipline;Disease;Disparity;Doctor of Philosophy;Electronic Nicotine Delivery Systems;Eligibility Determination;Environment;Equity;ethnic diversity;Etiology;Evaluation;Event;Extramural Activities;Faculty;faculty mentor;falls;Feedback;Funding;gender diversity;Genomics;Germ Lines;Goals;Grant;Guidelines;Health;Health behavior and outcomes;health equity;Health Promotion;Health Services Research;high risk population;implementation/effectiveness;Improve Access;improved;improved outcome;Incubators;individualized prevention;innovation;Institution;Intervention;Investments;Journals;Knowledge;Leadership;Life Style;Malignant neoplasm of lung;Malignant Neoplasms;meetings;member;Meridians;Minority;Mission;Modeling;Molecular;Molecular Epidemiology;NCI Center for Cancer Research;novel;Outcome;Peer Review;Peer Review Grants;Persons;Phase;Policies;Population;population health;Population Heterogeneity;Population Sciences;Pre-Clinical Model;prevent;Prevention;Process;programs;protocol development;public policy on tobacco;Publications;Quality of life;quality of life for cancer survivors;racial diversity;recruit;Reporting;Research;Research Personnel;research study;Resource Sharing;Resources;response;Risk;Role;Scholarship;Science;Scientist;screening;Services;Shapes;social health determinants;Source;Strategic Planning;Structure;Study Section;survivorship;Talents;Techniques;Testing;tobacco control;tobacco regulatory science;Training;Training and Education;Training Programs;Translating;Translational Research;translational study;underserved community;United States National Institutes of Health;Universities;Vulnerable Populations;Washington;Work;working group;Writing

PROJECT_TITLE: Cancer Prevention & Control


NIH_SPENDING_CATS: Cancer;Genetics;Prevention

PI_NAMEs: KUPFER, GARY M. (contact)

PROJECT_TERMS: Achievement;Address;anti-cancer research;Area;Basic Science;biobank;Biological;biomarker identification;Biotechnology;Breast;Cancer Biology;Cancer Burden;cancer cell;Cancer Center Support Grant;Cancer Control;Cancer Etiology;cancer prevention;cancer risk;Cancer Science;Catchment Area;Cell Separation;Cells;Cellular biology;Clinical;clinical care;Clinical Investigator;clinical translation;Collaborations;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Defect;Development;Direct Costs;DNA Damage;drug development;drug repurposing;early-career faculty;Epigenetic Process;equity, diversity, and inclusion;Event;Evolution;Faculty;Flow Cytometry;Flow Cytometry Shared Resource;Funding;Funding Agency;Gene Expression;Genetic;genome wide association study;Genomics;Goals;Home;homologous recombination;improved;Infusion procedures;Intellectual Property;International;Intervention;Investigational Therapies;investigator-initiated trial;Journals;Lead;Legal patent;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Mediating;member;Mentors;Mentorship;Molecular;molecular oncology;novel;oncology program;Pathway interactions;Patients;Peer Review;Pharmaceutical Preparations;Phase;Physiological;Process;programs;Publications;recruit;refractory cancer;Regulation;Research;Research Personnel;Resource Sharing;response;RNA Splicing;Science;Signal Transduction;small molecule;Source;Structure;synergism;Therapeutic;therapeutic target;tissue culture;Training and Education;Transcriptional Regulation;Translations;Underrepresented Populations;United States National Institutes of Health;Universities;Variant;working group

PROJECT_TITLE: Cancer Cell Biology Program


PI_NAMEs: BYERS, STEPHEN W (contact)

PROJECT_TERMS: Adoption;Advisory Committees;Animal Model;Animals;anti-cancer research;Applications Grants;Award;biobank;Bioinformatics;Biology;Biometry;Budgets;Cancer Center;Cancer Center Support Grant;Capital;Cell Separation;Chronic;Collection;Communication;community center;Comprehensive Cancer Center;Computer software;cost effective;cost efficient;Data;data acquisition;Data Analyses;Development;Doctor of Philosophy;Drug Kinetics;Education;Ensure;epigenomics;Equipment;Evaluation;Extramural Activities;Flow Cytometry;Fostering;Funding;Generations;Genomics;Goals;Grant;Health;Histopathology;Human Resources;Image;innovation;instrument;Investments;Journals;Leadership;Magnetic Resonance Imaging;mass spectrometric imaging;Mass Spectrum Analysis;meetings;member;Meridians;Methods;Microscopy;Mission;NCI Center for Cancer Research;neoplasm resource;New Jersey;new technology;operation;Peer Review;Pharmacodynamics;Pharmacology;Policies;Procedures;Productivity;programs;Publications;Qualifying;Quality Control;Recommendation;recruit;Reporting;Research;Research Activity;Research Personnel;Research Priority;Research Project Grants;Resource Sharing;Resources;satisfaction;Science;Services;Site;Strategic Planning;Students;Suggestion;Surveys;System;Technology;tissue culture;Tissues;Training;United States National Institutes of Health;Universities;Vendor;Vision;voucher;web site;Zebrafish

PROJECT_TITLE: Shared Resource Management


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: CARTER-BAWA, LISA  (contact)

PROJECT_TERMS: Achievement;Address;Area;Asian population;Award;bilingualism;Black Populations;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;Catchment Area;Clinical;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community based research;Community Clinical Oncology Program;community collaboration;community engaged research;community engagement;Community Health Education;Community Outreach;Comprehensive Cancer Center;Continuity of Patient Care;Counseling;County;Diagnosis;Discipline of Nursing;District of Columbia;Doctor of Philosophy;Early Diagnosis;Education;Equity;ethnic diversity;ethnic minority;Evaluation;evidence base;Funding;Genetic Counseling;genetic risk assessment;genetic testing;Geography;Gifts;Goals;Grant;Guidelines;Health;Health Disparities Research;Health education;Health Services Accessibility;Health Services Research;Hematologic Neoplasms;High-Risk Cancer;Hispanic;Home;improved;Institution;International;Justice;Latinx;Leadership;Legal;life span;lung cancer screening;male health;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Maryland;member;Minority;minority health;minority health disparity;Modeling;Monitor;NCI Center for Cancer Research;Needs Assessment;New Jersey;outreach;patient population;Persons;Policies;Population;Population Heterogeneity;Prevention;programs;racial diversity;racial minority;Research;Risk Factors;Role;screening;Screening for cancer;Site;smoking cessation;social determinants;social health determinants;sociodemographics;Strategic Planning;survivorship;Testing;Therapeutic;translational engagement;Translational Research;underserved community;Underserved Population;Universities;Virginia;Vulnerable Populations;Wellness Program

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Prevention

PROJECT_TERMS: Basic Science;cancer cell;Cancer Center Support Grant;Cancer Control;cancer prevention;career development;Catchment Area;Categories;Cellular biology;Clinical Sciences;Collaborations;Comprehensive Cancer Center;Decision Making;Development;Direct Costs;equipment acquisition;Faculty;Funding;Funding Agency;Grant;Histopathology;Immunotherapy;innovation;interdisciplinary collaboration;Investments;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;Operative Surgical Procedures;Pharmacology Shared Resource;Pilot Projects;Population Sciences;programs;Publications;Radiation Oncology;recruit;Research;research and development;Research Personnel;Research Project Grants;Resource Development;Resource Sharing;Science;Slide;Source;Strategic Planning;success;Tissues;Universities;voucher

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Advisory Committees;anti-cancer research;Area;Attention;Award;Cancer Center Support Grant;cancer research center director;Catchment Area;Clinical Data;Clinical Protocols;Clinical Research;Clinical Services;cohesion;Collaborations;Communication;Communities;community center;community engagement;Community Outreach;Compassion;Comprehensive Cancer Center;Creativeness;Data Collection;data management;Decision Making;Development;disparity elimination;disparity reduction;Ensure;Equity;equity, diversity, and inclusion;Evaluation;Faculty;Faculty Recruitment;Family;Feedback;Fostering;Funding;Future;Goals;Health;Health Services Accessibility;Improve Access;improved;Individual;Infrastructure;Institution;instrument;Investments;Knowledge;Leadership;Malignant Neoplasms;member;Meridians;Methods;Mission;Monitor;NCI Center for Cancer Research;operation;Operations Research;Peer Review;prevent;Process;process improvement;programs;Publications;recruit;Research;Research Activity;Research Design;Research Support;Resource Sharing;Resources;Review Committee;Schools;Scientific Advances and Accomplishments;Severities;Strategic Planning;Strategic vision;Surveys;Training;Training and Education;Translational Research;Universities;Vision;Voice;Woman;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Social Determinants of Health

PI_NAMEs: NOEL, MARCUS S (contact)

PROJECT_TERMS: Academic Medical Centers;Adult;aged;anti-cancer research;Budgets;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Catchment Area;Childhood;Clinical Cancer Center;Clinical Data;Clinical Investigator;Clinical Management;Clinical Protocols;Clinical Research;Clinical Research Protocols;clinical research site;Clinical Trials;community engagement;Community Outreach;Comprehensive Cancer Center;Conceptions;Conduct Clinical Trials;Contracts;Data;data integrity;data management;Development;Diagnosis;Disease;District of Columbia;Enrollment;Ensure;ethnic minority;Health;Hospitals;Individual;Information Dissemination;Infrastructure;Institution;Institutional Review Boards;Intervention;Intervention Studies;Investigational Drugs;investigator-initiated trial;Leadership;life span;Maintenance;Malignant Neoplasms;Meridians;Minority;Monitor;New Jersey;Occupational activity of managing finances;Office Management;operation;participant safety;patient population;patient screening;Patients;Peer Review;Performance;Policies;Procedures;process improvement;Protocol Compliance;Protocols documentation;Publications;quality assurance;Quality Control;racial minority;real time monitoring;recruit;Regulation;Reporting;Research;research study;Research Support;Research Training;Resources;Safety;safety outcomes;Science;Services;Site;Standardization;Strategic Planning;System;Time;Training and Education;Training Programs;Translations;Underserved Population;United States National Institutes of Health;Universities;University Hospitals;Washington;Woman

PROJECT_TITLE: Clinical Protocol and Data Management


PI_NAMEs: GIBNEY, GEOFFREY  (contact)

PROJECT_TERMS: Attention;authority;Biometry;Cancer Center;Cancer Center Support Grant;Catchment Area;Clinical Investigator;Clinical Research;Comprehensive Cancer Center;Data;design;Discipline;Disease;Enrollment;Ensure;Equilibrium;equity, diversity, and inclusion;Faculty;Goals;Health;Hospitals;human subject;Human Subject Research;Individual;Institution;Institutional Review Boards;Leadership;Malignant Neoplasms;medical schools;Medicine;meetings;member;Meridians;Methods;mid-career faculty;Monitor;NCI Center for Cancer Research;Peer Review;Performance;Policies;Population;Procedures;Process;professor;programs;prospective;Protocols documentation;Recommendation;Reporting;Research;Research Design;research study;Resources;Review Committee;Risk;Safety;Science;Scientist;sound;System;trial design;Underrepresented Minority;Universities;Washington;Work

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: TAN, MING TONY (contact)

PROJECT_TERMS: Agreement;American Association of Cancer Research;Animals;anti-cancer research;application programming interface;Architecture;Basic Science;Big Data;Bioinformatics;Bioinformatics Shared Resource;biomathematics;biomedical informatics;Biometry;Biostatistical Methods;Businesses;cancer cell;Cancer Center Support Grant;Cancer Control;cancer genomics;Cancer Hospital;cancer prevention;Cancer Research Infrastructure;Cancer Research Project;Case Report Form;Case Study;Cellular biology;Clinic;Clinical;Clinical Protocols;Clinical Research;Clinical Sciences;Clinical Trials;Cloud Computing;cohort;Collaborations;Collection;Communication;Comprehensive Cancer Center;Computational Biology;computer infrastructure;Computer Models;computing resources;Consultations;Data;Data Analyses;Data Commons;data integration;data management;Data Sources;Department chair;design;Development;disease registry;Doctor of Philosophy;Education;Educational workshop;Electronic Health Record;Environment;epigenomics;experience;Extramural Activities;Faculty;Fluorescence;Fostering;Funding;Funding Agency;Future;GENIE;Genomics;genomics cloud;Goals;graduate student;high dimensionality;Human;Image;Image Analysis;Immune;Informatics;informatics training;Information Services;Infrastructure;innovation;Institution;Investigation;investigator-initiated trial;Journals;Laboratories;Lead;Leadership;Maintenance;Malignant Neoplasms;Manuscripts;mass spectrometry shared resource;member;Mentors;Mentorship;Metadata;Methodology;Methods;mid-career faculty;Modeling;molecular diagnostics;Molecular Target;Monitor;multidisciplinary;Natural Language Processing;NCI Center for Cancer Research;neoplasm registry;next generation sequencing;novel;Office Management;Oncology;Pathway Analysis;Patient-Focused Outcomes;Peer Review;Pharmacology Shared Resource;Population Sciences;precision medicine;Preparation;Principal Investigator;programs;Protocols documentation;Publications;Qualifying;randomized, clinical trials;recruit;Reporting;Research;Research Design;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Safety;Sample Size;Science;Secure;Services;Site;Standardization;Statistical Data Interpretation;Statistical Models;success;Surveys;System;systems research;Techniques;tool;Training;transcriptome sequencing;transcriptomic profiling;Translational Research;trial design;Tumor Biology;Universities;usability;virtual;web services;Work

PROJECT_TITLE: Biostatistics & Bioinformatics Shared Resource


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer

PI_NAMEs: ALBANESE, CHRISTOPHER  (contact)

PROJECT_TERMS: Accreditation;Animal Cancer Model;Animal Experiments;animal facility;animal imaging;Animal Model;Animal Technicians;Animal Welfare;Animals;Area;Autopsy;Bioinformatics Shared Resource;Bioluminescence;Biometry;Blood;Blood specimen;Breeding;cancer cell;Cancer Center Support Grant;Cancer Control;cancer initiation;Cancer Model;cancer prevention;cancer type;Cell Line;Cells;Cellular biology;Collaborations;Collection;comparative;Comprehensive Cancer Center;cost effective;Data;design;Development;Diet;Doctor of Philosophy;Dose;Dual-Energy X-Ray Absorptiometry;Endocrine;Equipment;experience;experimental study;Extramural Activities;Fluorescence;Funding;Generations;Genetic;Genetic Engineering;Genetic Models;Genomics;Goals;Grant;Histopathology;Housing;Human;Human Resources;human tissue;Image;Image Analysis;imager;imaging facilities;imaging modality;imaging study;Immune system;Immunocompetent;immunodeficiency;immunodeficient mouse model;in vivo;innovation;instrument;International;investigator training;Journals;Laboratories;Laboratory Animal Production and Facilities;Life Cycle Stages;Magnetic Resonance Imaging;Maintenance;Malignant Neoplasms;Medicine;member;Metabolism;Methodology;Methods;Microscopy;Modeling;Molecular;Monitor;mouse model;Mus;Neoplasm Metastasis;novel;Oncology;Operative Surgical Procedures;Outcome Assessment;Pathologic;patient derived xenograft model;Performance;Pharmaceutical Preparations;Pilot Projects;Policies;pre-clinical;preclinical imaging;preclinical study;Procedures;programs;Publications;Regulation;Research;Research Personnel;Research Project Grants;Resistance;Resolution;Resource Sharing;Resources;Rodent;Role;Running;screening;Secure;serial imaging;Services;Site;skills;Spectrum Analysis;Statistical Data Interpretation;Students;success;Surgeon;Surgical Models;Teacher Professional Development;Techniques;Therapeutic;Tissue Banks;Tissue Sample;Tissues;tool;Toxic effect;Training;Training Programs;translational cancer research;translational study;treatment response;tumor growth;tumor initiation;ultrasound;United States Department of Agriculture;United States National Institutes of Health;Universities;Work;X-Ray Medical Imaging;Xenograft procedure;Zebrafish

PROJECT_TITLE: Animal Models Shared Resource


PI_NAMEs: CRESWELL, KAREN A (contact)

PROJECT_TERMS: Address;Advisory Committees;anti-cancer research;Antibodies;Apoptotic;base;Basic Science;Biomedical Research;Blood specimen;cancer cell;Cancer Center Support Grant;cell analyzer;Cell Cycle;Cell Separation;Cell surface;Cells;Cellular Assay;Cellular biology;Clinical;Clinical Trials;Color;Communication;Comprehensive Cancer Center;Computer software;Consultations;cost;Cytometry;Data Analyses;design;Development;dimensional analysis;Discipline;Doctor of Philosophy;Dry Ice;Education;Ensure;experience;experimental study;Extramural Activities;flexibility;Flow Cytometry;Flow Cytometry Shared Resource;Fluorescence-Activated Cell Sorting;Freezing;Funding;Grant;Human;human tissue;Ice;Immune;Immunophenotyping;improved;innovation;instrumentation;Journals;Knowledge;Label;Location;Malignant Neoplasms;mass spectrometer;meetings;member;Metals;Methodology;Methods;Mission;Molecular;Mus;Names;nanoparticle;Nature;operation;Oxidative Stress;Persons;Preparation;Procedures;Process;programs;Publications;Reagent;Research;Research Personnel;Research Project Grants;Resource Sharing;Sampling;Schedule;Services;Shipping;Site;Stains;Standardization;stem cells;success;Surveys;Suspensions;System;Technology;Time;tool;Training;Transfection;Translational Research;Tumor-Infiltrating Lymphocytes;Universities;webinar

PROJECT_TITLE: Flow Cytometry Shared Resource


PI_NAMEs: RESSOM, HABTOM W (contact)

PROJECT_TERMS: Advisory Committees;Affinity;anti-cancer research;Basic Science;Binding;Bioconductor;Bioinformatics;Bioinformatics Shared Resource;Biology;Biometry;cancer cell;Cancer Center Support Grant;Cancer Control;cancer prevention;Cell Death;Cells;Cellular biology;Chromium;Clinical Trials;cloud based;Cloud Computing;Collaborations;Comprehensive Cancer Center;Consultations;Copy Number Polymorphism;cost effective;Data;Data Analyses;data management;Development;digital;DNA;DNA Methylation;DNA methylation profiling;DNA sequencing;Doctor of Philosophy;drug development;Emerging Technologies;epigenomics;Experimental Designs;Expression Profiling;Extramural Activities;Fostering;Funding;Gastroenterology;Genomics;Grant;Histopathology;instrument;Journals;Label;Laboratories;Malignant Neoplasms;Manuscripts;member;Messenger RNA;miRNA expression profiling;Mission;mRNA Expression;nano-string;NCI Center for Cancer Research;next generation sequencing;novel therapeutics;Nucleic Acids;Oncogenes;Pathway Analysis;Peer Review;Polymerase Chain Reaction;programs;Proteins;Publications;Publishing;Reader;Research;Research Activity;Research Personnel;Research Project Grants;Resource Sharing;RNA;sequencing platform;Services;single-cell RNA sequencing;small molecule;small molecule libraries;SNP genotyping;Software Tools;Spectrophotometry;success;Surface Plasmon Resonance;Surveys;System;Technology;technology platform;Time;Tissues;tool;Training;Training and Education;Translational Research;Universities

PROJECT_TITLE: Genomics & Epigenomics Shared Resource


PI_NAMEs: JOHNSON, MICHAEL D (contact)

PROJECT_TERMS: Advisory Committees;analytical tool;Antibodies;Brightfield Microscopy;cancer cell;Cancer Center Support Grant;Cancer Control;cancer prevention;Cellular biology;cellular imaging;Comprehensive Cancer Center;Computer software;confocal imaging;Confocal Microscopy;Consult;Custom;Data;data acquisition;Data Analyses;Dedications;detector;Development;Doctor of Philosophy;Education;Educational workshop;Equipment;experience;Experimental Designs;Extramural Activities;Faculty;Fluorescence;fluorescence lifetime imaging;Fluorescence Microscopy;Fluorescence Recovery After Photobleaching;Fluorescence Resonance Energy Transfer;Fluorescence Spectroscopy;Funding;Future;Goals;Grant;Image;Image Analysis;image reconstruction;imaging approach;imaging capabilities;Imaging Device;imaging modality;imaging platform;imaging system;Imaging technology;instrumentation;Journals;Lasers;lectures;Light;Maintenance;Malignant Neoplasms;member;metabolic imaging;Methods;Microscopy;Molecular Cytogenetics;molecular imaging;multi-photon;multiphoton imaging;novel;optical imaging;Optics;Organoids;Outcomes Research;Paper;Phase;Pilot Projects;Preparation;programs;Publications;Quality Control;Reagent;Recommendation;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;response;Running;Sampling;Scanning;Services;Speed;Strategic Planning;success;superresolution imaging;Supervision;Surveys;System;Technology;Time;Tissue imaging;Tissues;Training;Universities;Work;Zebrafish

PROJECT_TITLE: Microscopy & Imaging Shared Resource