NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Cancer;Liver Disease;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

PHR: PROJECT NARRATIVE The goal of our Program Project is to conduct several research studies to better understand and reduce the risk of developing the most common type of liver cancer, hepatocellular carcinoma (HCC), among individuals with metabolic dysfunction (e.g., diabetes, obesity). These studies require collecting, shipping, processing and storage of serial blood samples that can be linked to demographic and clinical data from patients of the clinical sites within the Texas HCC Consortium. The Biospecimen and Biomarker Development Core will serve as the central location that will fully support these functions and produce high-quality DNA and serum for research projects, and also provide and conduct biomarker discovery and validation assays for the proposed studies.

PI_NAMEs: SCHEURER, MICHAEL E. (contact)

PROJECT_TERMS: Adult;Aliquot;assay development;Bar Codes;biobank;Biochemical Markers;Biological;Biological Assay;Biological Markers;biomarker development;biomarker discovery;biomarker validation;Blood specimen;Catalogs;Characteristics;Chemoprevention;Cirrhosis;Clinical;Clinical Data;clinical research site;cohort;Collection;college;Comprehensive Cancer Center;cost;cost effectiveness;cost estimate;Data;Databases;Detection;Development;Diabetes Mellitus;DNA;early detection biomarkers;Ensure;Equipment and supply inventories;ethnic disparity;ethnic diversity;fatty liver disease;follow-up;Functional disorder;Future;Genetic Markers;Germ Lines;Goals;Health protection;Individual;Institution;Investigation;Knowledge;Label;Link;Location;Malignant neoplasm of liver;Medicine;Metabolic;Metabolic dysfunction;Metabolic syndrome;Modeling;mortality;novel marker;Obesity;Participant;Patient Participation;Patients;phenotypic biomarker;Plasma;Population;Population Sciences;Populations at Risk;Preparation;Prevention;Prevention strategy;Primary carcinoma of the liver cells;Procedures;Process;professor;programs;Prospective cohort;protective factors;Protocols documentation;racial disparity;racial diversity;Research;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Risk Factors;Risk Reduction;Sampling;Serum;Services;Shipping;Specimen Handling;Standardization;success;synergism;Testing;Texas;Time;Translational Research;Validation;Work

PROJECT_TITLE: Biospecimen & Biomarker Development Core


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Syntax, the abstract structure of language, is a uniquely human ability that is critical for communication, yet little remains known about its neural instantiation. We take a novel approach, leveraging prior computational and theoretical work and ECoG to study how syntax is used during speech production to correctly order words.

PI_NAMEs: MORGAN, ADAM M (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TITLE: Syntactic control of lexical activation during speech production - Resubmission - 1


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Networking and Information Technology R&D (NITRD);Nutrition;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The goal of our Program Project is to conduct several research studies to better understand and reduce the risk of developing the most common type of liver cancer, hepatocellular carcinoma (HCC), among individuals with metabolic dysfunction (e.g., diabetes, obesity). The proposed studies require rigorous implementation of well-designed protocols for patient enrollment and biospecimen and data collection, optimal and complete follow-up of patients with cirrhosis to determine if they develop HCC, and rigorous statistical analyses. Our proposed Data and Analysis Core will provide expertise and support in data management, coordination, statistics and information technology that are crucial for the success of all projects and the overall Program.

PI_NAMEs: AMOS, CHRISTOPHER I. (contact)

PROJECT_TERMS: Address;Biochemical Markers;biomarker development;biomarker discovery;biomarker validation;Blinded;central database;Chemoprevention;Chemopreventive Agent;Cirrhosis;Cities;Clinical;Clinical Research;cohort;college;comparative;Comprehensive Cancer Center;cost;dashboard;Data;Data Analyses;Data Collection;data harmonization;Data Linkages;data management;Data Set;design;Development;Diabetes Mellitus;Early Diagnosis;Effectiveness;Electronics;Enrollment;Ensure;epidemiologic data;Epidemiology;Equipment and supply inventories;Etiology;experience;fatty liver disease;follow-up;Functional disorder;Funding;Future;Genetic Markers;Goals;Human Resources;Individual;Informatics;Information Technology;Machine Learning;Malignant neoplasm of liver;Manuals;Mathematics;Medicine;member;Metabolic;Metabolic dysfunction;Metabolic syndrome;metabolic-associated fatty liver disease;Metformin;Mission;models and simulation;Monitor;mortality;multidimensional data;novel marker;Obesity;operation;Participant;participant enrollment;Patients;Persons;phenotypic biomarker;Prevention;Prevention strategy;Primary carcinoma of the liver cells;Process;professor;programs;Prospective cohort;Protocols documentation;quality assurance;recruit;Research Design;Research Personnel;research study;Resource Sharing;Resources;Retrieval;Retrospective cohort;Risk Factors;Risk Reduction;risk stratification;Sampling;Science;Services;Site;skills;Specimen;Statistical Data Interpretation;Statistical Methods;Statistical Models;statistics;stem;success;Support System;synergism;System;Technology;Testing;Texas;Thiazolidinediones;timeline;tool;Translational Research;United States Department of Veterans Affairs;Update;validation studies;Vertebral column;web platform;Work

PROJECT_TITLE: Data & Analysis Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Effective treatments are needed for iron-related disorders. This grant will characterize the coordinated regulation of intestinal HIF2α target genes by the microbiota and epigenetic reprogramming to target iron deficient anemia and hereditary hemochromatosis.

PI_NAMEs: SHAH, YATRIK M (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Adjuvant;Affect;Anemia;Antibodies;Binding;Blood;Cells;Chronic Kidney Failure;Clear cell renal cell carcinoma;Clinical Trials;clinically relevant;Data;Disease;Drug Targeting;druggable target;effective therapy;Elements;Epigenetic Process;epigenetic regulation;Epithelium;experimental study;gene network;Genes;Genetic Transcription;Grant;gut microbiota;Hematological Disease;Hemochromatosis;Hepatic;hepcidin;Hereditary hemochromatosis;HIF1A gene;histone modification;Homeostasis;Hormones;Hydrophobicity;Hypoxia Inducible Factor;in vivo;inhibitor;Intestinal Absorption;intestinal hypoxia;Intestines;Iron;iron absorption;iron deficiency;Iron deficiency anemia;iron metabolism;Iron Metabolism Disorders;Iron Overload;Ligand Binding;Liver;Mediating;Membrane Proteins;Metabolic Pathway;metal transporting protein 1;microbial;microbiota;mouse model;Mus;novel;novel therapeutics;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Physiological;Play;Pre-Clinical Model;promoter;Proteins;Publishing;Regulation;Renal Carcinoma;Reporter;Reporter Genes;Research;response;Role;sensor;Signal Transduction;Testing;Tissues;tool;transcription factor;Transgenic Organisms;Visualization;Work

PROJECT_TITLE: Control of iron absorption by intestinal HIF2 in iron and hematological disorders

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Heart Disease;Lung;Pediatric;Physical Activity;Physical Rehabilitation;Prevention;Pulmonary Hypertension;Rehabilitation

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Pediatric pulmonary hypertension is a life-threatening disease of the lung vasculature that can result in right heart failure and death, but the population of survivors is increasing due to pharmacologic advances. Survivors report low quality of life related to symptoms of exercise intolerance, and adult literature supports exercise training as an adjunct to pharmacologic therapy. The proposed training program and research studies aim to increase understanding of barriers to exercise in pediatric pulmonary hypertension survivors in order to pilot a home-based exercise program which may lead to new therapeutic approaches and improved quality of life.

PI_NAMEs: AVITABILE, CATHERINE M. (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Accelerometer;Activities of Daily Living;Adherence;Adopted;Adult;Adverse event;Aerobic;Age;Behavioral;behavioral construct;Body Composition;Cardiac;Cardiopulmonary;career;career development;Caring;Cessation of life;Child;Childhood;Clinical;clinical effect;Code;dashboard;Data;Densitometry;design;Development Plans;Dual-Energy X-Ray Absorptiometry;Endothelium;Exercise;exercise intervention;exercise intolerance;Exercise Physiology;exercise program;Exercise Therapy;exercise training;Family;feasibility testing;Fostering;Foundations;Fright;functional status;Future;Genetic Transcription;Goals;Health;Health Technology;Heart Diseases;Heart Rate;Home;improved;interest;Internet;Intervention;Interview;Leg;Life;Light;Literature;Lower Extremity;Lung Diseases;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;mHealth;mobile application;Modeling;Moderate Exercise;Monitor;Muscle;muscle strength;Nonpharmacologic Therapy;novel;novel therapeutic intervention;Outcome;Participant;Pathway interactions;Patient Recruitments;Patients;pediatric cardiologist;peer;Performance;Peripheral;Personal Satisfaction;pharmacologic;Physical activity;physical inactivity;Physicians;Population;preference;primary outcome;programs;Provider;Psychosocial Factor;Pulmonary Hypertension;Pump;Qualitative Methods;Quality of life;Questionnaires;recruit;Reporting;Research;research study;Resistance;Resources;response;right ventricular failure;secondary outcome;Secure;Self Efficacy;sensor;sex;Single ventricle congenital heart disease;Skeletal Muscle;skills;smart watch;social cognitive theory;Specialist;Specific qualifier value;Strategic Planning;Strenuous Exercise;Stroke Volume;Structure;Survivors;Symptoms;Testing;theories;therapy design;Thinness;Training;Training Programs;United States National Institutes of Health;Ventricular;Walking;wearable data;wearable device

PROJECT_TITLE: Understanding the Barriers to Physical Activity in Pediatric Pulmonary Hypertension in Order to Design Effective Home-based Exercise Programs

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Emerging Infectious Diseases;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative NeoChip combines real-time PCR, digital High Resolution Melting (dHRM) of DNA and RNA, and machine learning to create unique “fingerprints" for microbes and antimicrobial resistance, allowing for faster and more precise detection of pathogen(s) causing neonatal infection. This project will build out NeoChip’s melt curve database to include clinically relevant strains of cytomegalovirus and herpes simplex virus infections, while concordantly assembling updated epidemiologic timelines and prevalence of perinatal CMV and HSV transmission. Our goals are to validate NeoChip for the rapid and specific diagnosis of congenital CMV and neonatal HSV infection on multiple tissue matrices and translate the NeoChip platform for incorporation into standard universal newborn screening for the diagnosis of congenital cytomegalovirus on dried blood spot samples.

PI_NAMEs: LAWRENCE, SHELLEY M (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: accurate diagnosis;Address;Advocate;Anti-viral Agents;Anti-viral resistance;Antibiotics;Antibodies;antimicrobial;Antimicrobial Resistance;artificial intelligence algorithm;Base Sequence;biobank;Biological;Biological Assay;Birth;Blinded;Blood;Blood specimen;Blood Volume;California;Child;Clinical;clinical database;clinical outcome measures;Clinical Research;clinically relevant;Collaborations;congenital cytomegalovirus;Congenital herpes simplex;Consumption;cost;Culture Techniques;Cytomegalovirus;Data;Databases;Detection;detection limit;detection method;Diagnosis;diagnosis standard;Diagnostic;diagnostic biomarker;diagnostic tool;digital;disabled;Disease;disease prognosis;DNA;Dryness;Dyes;Early identification;Early Intervention;Enrollment;Epidemiology;Etiology;Evaluation;Failure;Fingerprint;Fluorescence;Funding;Genome;Genomic Segment;Genotype;Goals;Health;Herpes Simplex Infections;Hour;Immunoglobulin G;Immunoglobulin M;Individual;Infant;Infection;intercalation;interdisciplinary approach;intervention program;Investigation;Laboratories;Life;Machine Learning;machine learning algorithm;Measures;melting;Microbe;microbial;Modality;Modernization;Molecular;Mothers;multidisciplinary;Neonatal;neonatal infection;Neonatal Screening;neonate;Newborn Infant;next generation sequencing;Nucleic Acid Amplification Tests;Nucleotides;offspring;Outcome;pathogen;Pathogen detection;pathogen genomics;pathogenic virus;Pathogenicity;Patients;Perinatal;point of care;Polymerase Chain Reaction;postnatal;Predictive Value;Pregnant Women;Prevalence;prevent;prospective;rapid diagnosis;Reaction;reactivation from latency;Reporting;Research;Research Personnel;Resistance;resistance gene;Resolution;Risk;RNA;Saliva;Sampling;screening program;Simplexvirus;single molecule;Specificity;Spottings;Symptoms;Techniques;Technology;technology validation;Testing;Therapeutic;Therapeutic Intervention;Time;timeline;Tissues;Training;Translating;transmission process;Tube;United States;Universities;Update;Urine;Variant;Viral;Viral Load result

PROJECT_TITLE: NeoChip for specific and rapid identification of congenital CMV and neonatal HSV infections on minimal sample volume

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Bipolar Disorder;Brain Disorders;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Serious Mental Illness

ORG_CITY: CLIFTON PARK

ORG_NAME: KITWARE, INC.

PHR: PROJECT NARRATIVE  Brain microstructure changes occur during adolescent development, and the trajectory of these changes can be affected by the onset of mental disorders such as bipolar disorder. Understanding the neurobiology of this process requires longitudinal diffusion MRI datasets and diffusion models that have the specificity to distinguish between the different types of changes that occur during adolescent development. In this project, we will develop an open source software framework for analyzing developmental trajectories of brain microstructure based on advanced diffusion models applied to longitudinal datasets.

PI_NAMEs: EBRAHIM, EBRAHIM  (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;adolescent brain development;Adolescent Development;adolescent mental health;Adult;Affect;Algorithms;Anatomy;Antipsychotic Agents;Automobile Driving;Bipolar Disorder;Brain;Child Development;Child Health;cloud based;cognitive development;Communities;Computer software;Consumption;Data;data exploration;Data Set;Data Sources;deep learning;deep learning model;density;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;dimension reduction;Disease;early onset;Effectiveness;Environmental Health;experience;Fiber;flexibility;Generations;graphical user interface;Image;improved;indexing;Life;longitudinal analysis;longitudinal dataset;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mental disorders;Mental Health;Methodology;Modeling;Mood Disorders;multilevel analysis;neural;Neurites;Neurobiology;neuroimaging;open source;Pharmaceutical Preparations;Population;Process;regional difference;Research;research and development;Resolution;response;serial imaging;software development;Software Framework;Software Tools;Specificity;Speed;statistics;Structure;suicidal risk;Symptoms;Techniques;Time;tool;Visualization;white matter;Work

PROJECT_TITLE: Exploratory Analysis Tools for Developmental Studies of Brain Microstructure with Diffusion MRI


ADMINISTERING_IC: NS

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Narrative Our goal of this application is to develop a treatment in combination with standard care to induce immune memory against GBM recurrence. Such a study is highly relevance to human health.

PI_NAMEs: HEIMBERGER, AMY BETH;LI, SHULIN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Antibodies;Antibody Therapy;Biological;Brain;Brain Neoplasms;CAR T cell therapy;Cause of Death;CD3 Antigens;Cd68;Cell Maturation;cell motility;Cell Physiology;Cell secretion;Cell Therapy;Cells;Central Nervous System;Central Nervous System Neoplasms;Cessation of life;chemotherapy;Clinical;Collaborations;CXCL1 gene;cytokine;cytokine therapy;Cytomegalovirus;Data;Death Domain;Dedications;Dendritic Cells;Development;Effector Cell;efficacy evaluation;Endothelial Cells;Exposure to;Fibrinogen;Future;Glioblastoma;Glioma;Goals;Health;Human;Immune;immune checkpoint blockade;immune clearance;Immunocompetent;immunodeficiency;Immunoglobulin Fragments;Immunologic Memory;Immunology;Immunosuppression;Immunotherapy;improved;in vivo;Injections;Intracranial Neoplasms;ITGAX gene;Knock-out;Knockout Mice;Laboratories;life span;Lipopolysaccharides;Macrophage;Mediating;Membrane;Memory;Modeling;Mus;Nature;neoplastic cell;neutralizing antibody;next generation;novel;Paper;Patients;PECAM1 gene;Peptides;Peripheral;Phase;polyclonal antibody;Preparation;prevent;Prevention;programmed cell death ligand 1;Proteins;Publishing;Recurrence;Recurrent tumor;Regulatory T-Lymphocyte;Relapse;Research;residence;Role;Safety;Signal Transduction;Solid Neoplasm;Source;standard care;subcutaneous;T cell therapy;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;therapeutic candidate;tissue resident memory T cell;Tissues;TP53 gene;transcriptome sequencing;Translations;Transplantation;Treatment Efficacy;Treatment Failure;tumor;tumor growth;tumor progression;Tumor Promotion;Veins

PROJECT_TITLE: Fgl2 neutralizing therapy for inducing tumor specific brain resident immune memory against CNS tumor relapse

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The transition to adult HIV care is often accompanied by reduced medication adherence, retention in treatment, and HIV viral load suppression; however, little is known about which interventions might be most effective in supporting adolescents undergoing this care transition. We will estimate the short- and long-term efficacy of a community-based differentiated care intervention to support adolescents during their transition to adult HIV care; estimate the cost and cost-effectiveness in terms of cost per additional successful transition achieved; and provide data on implementation considerations essential for uptake, sustainability, and successful adoption by the public sector.

PI_NAMEs: FRANKE, MOLLY FORREST (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acute;Address;Adherence;Adolescence;Adolescent;Adoption;Adult;Advocate;Age;age group;Appointment;arm;barrier to care;Behavioral;Brain;Caregivers;Caring;Childhood;Chronic;Clinic;cohort;Communities;Community Health;Compensation;Complex;Continuity of Patient Care;Coping Skills;cost;cost effectiveness;cost estimate;Data;Development;Diagnosis;Disclosure;Disease Management;Disparity;Distress;early experience;early life adversity;economic evaluation;Education;Effectiveness;Effectiveness of Interventions;Emotional;Ensure;Environment;experience;Face;Health;Health Personnel;Health Services;Health system;Healthcare;HIV;HIV-infected adolescents;Homelessness;housing instability;implementation evaluation;implementation intervention;improved;Incidence;Informal Social Control;Insurance;Intervention;Intervention Studies;Intervention Trial;Latin America;Latin American;Life;Medical;medication compliance;Mental Health;Morbidity - disease rate;multidisciplinary;Neurocognitive;Outcome;Pathway interactions;Patients;peer;peer influence;peer networks;perceived stress;Personal Satisfaction;Peru;Pilot Projects;post intervention;Prefrontal Cortex;Pregnancy;programs;Provider;psychosocial;Psychosocial Assessment and Care;Puberty;Public Sector;Qualitative Methods;randomized trial;randomized, clinical trials;Readiness;Rewards;Risk;Risk Taking;screening;secondary endpoint;Self Efficacy;sexual debut;skills;Social isolation;social stigma;Social support;Substance Use Disorder;Support Groups;Testing;therapy design;Time;Training;transmission process;Trauma;Treatment Efficacy;uptake;Viral Load result

PROJECT_TITLE: Efficacy of a differentiated care intervention for adolescents transitioning to adult HIV care in Peru

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-M(53)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Nutritional behaviors and eating habits are affected gradually in Alzheimer’s disease making it hard to identify abnormal behaviors in the early stages. This research and training program will apply a novel strategy using a digital research system in real-world homes to characterize dietary behavior in healthy older adults, mild cognitive impairment and early Alzheimer’s disease. Once such strategies have been developed, they can be used to identify early changes in health, cognitive function and activity that could be predictive of memory loss and dementia, and provide an initial step towards the long-term goal of finding effective prevention and treatment strategies for Alzheimer’s disease and related dementias.

PI_NAMEs: WRIGHT, KIRSTEN  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Activities of Daily Living;Address;Affect;Age;age related;age-related disease;Aging;aging and technology;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Assessment tool;Award;Behavior;Behavioral;behavioral study;Biological Markers;Biology of Aging;Body Weight decreased;career;Clinic Visits;Clinical;Cognition;Cognitive;cognitive capacity;cognitive function;cognitive performance;cohort;Data;Data Reporting;Dementia;dementia risk;design;Desire for food;Development;Diagnosis;Diet Habits;dietary;Dietary intake;Dietary Practices;dietary supplements;digital;Digital biomarker;digital measure;digital technology;Dimensions;Disease;Early identification;Educational workshop;Enrollment;Evaluation;experience;Fingerprint;Food;frailty;functional improvement;functional independence;functional loss;functional outcomes;Future;Generations;Geriatrics;Gerontology;Goals;Health;Home;Hospitalization;Impaired cognition;improved;Individual;individual variation;Infrastructure;innovation;Institutionalization;Intake;International;Intervention;Intervention Trial;Laboratories;Life;Life Style;Link;Longitudinal Studies;Malnutrition;Measurable;Measurement;Measures;meetings;Memory Loss;Mental Depression;Mentors;Methods;mild cognitive impairment;mortality;multimodal learning;non-invasive system;novel;novel strategies;Nutrient;nutrition;Nutrition Assessment;Nutritional;older adult;Oregon;Outcome;Outcome Measure;Participant;Patient Self-Report;Patients;Pattern;peer;Persons;preservation;Prevention strategy;programs;Questionnaires;Reporting;Research;Research Project Grants;Risk;sensor;Severity of illness;skills;Statistical Data Interpretation;Symptoms;System;systems research;Techniques;Technology;technology platform;Testing;Time;tool;Training;training opportunity;Training Programs;treatment strategy;wearable sensor technology

PROJECT_TITLE: Longitudinal Characterization of Nutritional Behavior Using Unobtrusive Digital Technology in Aging, Alzheimer's and Related Disorders

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Brain Disorders;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Moderate or severe traumatic brain injury (TBI) is a substantial health problem that in addition to often-devastating acute effects, can trigger chronic and evolving neuropathologies that may underlie long-term functional decline. Here we propose to further understanding of how TBI can induce chronic and progressive degeneration of the brain's white matter. We will achieve this by examining human tissue samples in parallel with translational models of TBI to explore degeneration, including at the individual cell level and across brain networks.

PI_NAMEs: JOHNSON, VICTORIA ELEANOR (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute;Address;Alzheimer's Disease;Animal Model;Atrophic;Autopsy;Axon;axonal degeneration;behavioral outcome;Brain;Brain Concussion;Cell Death;cell injury;Cell Survival;Cells;Chronic;Chronic Phase;Complex;Cytoskeleton;Data;design;Development;Diffuse Axonal Injury;Diffuse Brain Injury;Dropout;Family suidae;Focal Brain Injuries;functional decline;Functional disorder;Health;Human;human tissue;Impaired cognition;Individual;injured;Injury;Interruption;JUN gene;Lesion;Light;Measurement;Mechanics;Modeling;Mus;Nature;Nerve Degeneration;neural network;Neurocognitive Deficit;Neurodegenerative Disorders;neurofilament;neuron loss;Neurons;neuropathology;new therapeutic target;novel;Outcome;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;Phase;Phenotype;Phosphotransferases;postsynaptic;postsynaptic neurons;pre-clinical;Process;Reporting;Retrograde Degeneration;Role;Sampling;Secondary to;Serum;Signal Pathway;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Sports;Swelling;Synapses;Syndrome;targeted treatment;TBI Patients;Techniques;Therapeutic Intervention;three-dimensional visualization;Time;Tissue Sample;Tissues;Tracer;translational model;translational study;Trauma;Traumatic Brain Injury;Viral;white matter;white matter injury

PROJECT_TITLE: Mechanisms of Chronic Progressive Axon Degeneration Following TBI

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Narrative Ozone is a ubiquitous urban air pollutant that causes significant adverse health effects in healthy and susceptible individuals, including children and the elderly. Our studies are focused on elucidating inflammatory mechanisms contributing to ozone toxicity in humans and experimental animals. This is key to development of new strategies to reduce lung injury and disease arising from exposure to ozone, as well as other agents that cause inflammatory lung damage.

PI_NAMEs: LASKIN, DEBRA L (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acute;Air Pollutants;Animal Experiments;Anti-Inflammatory Agents;Area;Asthma;asthma exacerbation;Cells;Child;Chronic;Chronic lung disease;Classification;constriction;Development;Disease;Elderly;Energy-Generating Resources;Exposure to;Genes;Genetic Transcription;Glycolysis;Goals;Health;Homeostasis;Human;Impairment;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Inhalation;insight;irritation;Ligands;Link;lipid metabolism;Lipids;Lung;Lung Diseases;lung injury;Macrophage;Macrophage Activation;Mediating;Mediator;Metabolic;metropolitan;MicroRNAs;Mus;novel;Nuclear Receptors;Oxidative Phosphorylation;Ozone;ozone exposure;Pathogenesis;Pathogenicity;Pathology;Phenotype;Play;PPAR gamma;Predisposition;prevent;Process;Production;Public Health;Pulmonary Emphysema;pulmonary function;Pulmonary Inflammation;receptor;Repression;Resolution;response;Role;Signal Transduction;Smog;Testing;tissue injury;Tissues;Toxic effect;transcription factor;translational study

PROJECT_TITLE: Activated Macrophages and Ozone Toxicity

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE At over half million patients and counting, the chronic dialysis population includes some of the costliest and sickest patients in the United States. Findings from this proposal will help identify optimal dialysis modality choices (home versus in-center) in order to reduce spending and improve their clinical outcomes.

PI_NAMEs: HIRTH, RICHARD A;HOLLINGSWORTH, JOHN MALCOLM;SHAHINIAN, VAHAKN B (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Acute;Affect;Age;American;Attention;black patient;Black race;Blood Circulation;Budgets;care delivery;care outcomes;Caring;Chronic;Chronic Care;Clinical;comorbidity;Congestive Heart Failure;Controlled Clinical Trials;cost;Country;Data;Death Rate;Diabetes Mellitus;Dialysis patients;Dialysis procedure;Disparity population;Educational Models;End stage renal failure;Ensure;Ethnic Origin;financial incentive;Goals;Health;Health Benefit;Health Care Costs;health care service utilization;Healthcare;Heart failure;Hemodialysis;Heterogeneity;Hispanic;Home;Home Hemodialysis;Hospital Referrals;hospital utilization;Housing;improved;Infection;innovation;Investments;Kidney;Kidney Transplantation;Life;Low income;Measures;Medicaid eligibility;Medical;Medicare;Medicare/Medicaid;Modality;Modeling;Organ;Outcome;Participant;patient population;patient subsets;Patients;peer;Peritoneal Dialysis;Peritonitis;Physiological;Population;preservation;Procedures;Provider;Quasi-experiment;Random Allocation;Renal function;Residual state;Resources;Risk;social;stem;time use;Transplantation;treatment choice;Uncertainty;United States;Uremia

PROJECT_TITLE: Leveraging the ESRD Treatment Choices model to understand the benefits of home versus in-center dialysis

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunization;Immunotherapy;Lymphatic Research;Vaccine Related;Women's Health Research

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Narrative Most cancer types are not responsive to checkpoint blockade immunotherapy and the majority of patients with cancers known to be responsive do not benefit from it. This research proposal will use state-of the-art technologies of imaging, world-renowned expertise in cancer vaccine design and production, single cell RNA sequencing, immunoprofiling, and multiplex immunofluorescence to show that by harnessing the lymphatics, immune responses can be personalized. The implications for this research extend beyond cancer to autoimmune and infectious diseases that benefit by immunomodulatory interventions.

PI_NAMEs: MOHSEN, MONA ;SEVICK, EVA M. (contact);ZHAO, ZHONGMING

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: 4T1;Affect;Age;Animals;anti-tumor immune response;Antigen Presentation;Antigens;Antitumor Response;Autoantigens;Autoimmune Diseases;Bacteriophages;Binding;Bioinformatics;Breast Cancer Patient;Breast Carcinoma;Cancer Center;Cancer Detection;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;cancer vaccination;Cancer Vaccines;cell assembly;cell type;Cells;central tolerance;Clinical;Clinical Research;clinical translation;Clonal Expansion;Collaborations;combat;Combination immunotherapy;Combined Modality Therapy;Communicable Diseases;Cross Presentation;Cucumber mosaic virus;Data;Dendritic Cells;Development;Disease;Dose;draining lymph node;Drug Delivery Systems;Educational process of instructing;Effectiveness;Environment;exhaust;exome sequencing;experience;Growth;Health Sciences;image guided;Imaging technology;immune checkpoint blockade;Immune response;immune-related adverse events;Immunity;Immunofluorescence Immunologic;Immunologic Tests;Immunologics;Immunology;immunoregulation;Immunotherapy;improved;Infiltration;Intervention;Intravenous;intravenous administration;Ligands;Link;lymph nodes;Lymphatic;lymphatic imaging;Malignant Neoplasms;man;Mass Spectrum Analysis;Metastatic Neoplasm to Lymph Nodes;Modeling;mouse model;multidisciplinary;Mus;neoantigen vaccination;neoantigens;Neoplasm Circulating Cells;Normal tissue morphology;Pathology;Patients;peripheral tolerance;permissiveness;personalized cancer vaccines;Phenotype;Plants;Predisposition;prevent;Privatization;Regulatory T-Lymphocyte;Relapse;Research;Research Proposals;response;safety testing;Signal Transduction;single cell analysis;single-cell RNA sequencing;Site;Switzerland;T cell response;T-cell receptor repertoire;T-Lymphocyte;Technology;Texas;Time;TLR9 gene;transcriptomics;Transgenic Mice;Translating;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;Tumor Escape;tumor growth;Tumor-Infiltrating Lymphocytes;Universities;Vaccinated;Vaccination;Vaccine Design;Vaccine Production;Vaccines;Virus-like particle;Woman;Work

PROJECT_TITLE: Personalized, antigen-directed immunotherapy delivered to lymph nodes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Immunotherapy

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Determination of chromatin protein dynamics in CD8 T cells  CD8 T cells are driven by T cell antigen receptor (TCR) and co-receptor signaling via transcriptional regulation of gene expression to confer antiviral and antitumor immune response. Here we propose to unbiasedly determine the protein factors dynamically associated with active gene enhancers and promoters in CD8 T cells upon TCR and co-receptor stimulation, potentially leading to the identification of novel modulators of CD8 T cell antitumor activity.

PI_NAMEs: FENG, YONGQIANG  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Acetylation;anti-tumor immune response;Antibodies;Antigens;Binding;Bioinformatics;Biological;Biotinylation;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;Cells;Cellular biology;Cellular immunotherapy;Chromatin;chromatin protein;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;Coupled;CRISPR screen;Cues;cytokine;Enhancers;Epigenetic Process;epigenetic profiling;epigenetic regulation;experimental study;extracellular;FOXP3 gene;Gene Expression;Gene Expression Regulation;Genes;genetic element;Genetic Transcription;genome editing;Genomic Segment;Goals;Histone Acetylation;Histone H3;immune function;Immune response;Immune System Diseases;Immunologics;improved;In Situ;In Vitro;in vivo;inducible gene expression;Infiltration;innovation;interest;Interleukin-2;Investigation;Knock-out;Libraries;Lysine;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Methods;Mus;novel;Nuclear;Nuclear Proteins;Outcome;Pathway interactions;Physiological;Play;Process;programs;promoter;Protein Dynamics;Proteins;Proteomics;receptor;Receptor Signaling;recruit;Regulatory T-Lymphocyte;Research;response;Role;screening;Signal Pathway;Signal Transduction;System;T cell differentiation;T cell response;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Time;Transcriptional Regulation;Transducers;tumor;Tumor Immunity;Viral;Work

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative The proposal is expected to establish a mechanistic link between altered expression of mitochondrial complex 1, metabolic rewiring via NUDUFB8-GLS1 axis, investigate the therapeutic inhibitors in AA BLCA and the tumor immune microenvironment using clinically relevant models of AA BLCA.

PI_NAMEs: GAO, JIANJUN ;PUTLURI, NAGIREDDY  (contact);SIDDIQUI, MOHUMMAD MINHAJ

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Address;Affect;African American;American;Automobile Driving;Basic Science;Bioinformatics;Biological;Biology;Biometry;Cancer Biology;cancer gene expression;cancer health disparity;Cancer Patient;cancer type;carboxylation;Cell Communication;Cell Line;checkpoint therapy;Citric Acid Cycle;Clinical;Clinical Management;clinically relevant;cohort;combinatorial;Complex;Coupled;Cytometry;Data;Dependence;Disparity;Electron Transport;Energy Metabolism;European;experimental study;Fatty Acids;field study;follow-up;Foundations;Gene Expression Profiling;Genes;Genetic;genome-wide;Glutaminase;Glutamine;Goals;Growth;health care availability;Histocytochemistry;Human;humanized mouse;Image;immune activation;Immune signaling;Immunologics;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Inferior;inhibitor;inhibitor therapy;insight;Institution;Interferon alpha;Interferon Type II;Interferons;Intervention;Investigation;knock-down;Knock-out;Link;loss of function;Malignant neoplasm of urinary bladder;Malignant Neoplasms;mass spectrometric imaging;Mass Spectrum Analysis;Measures;Mediating;Mediator;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;mitochondrial metabolism;Modeling;Molecular;mortality;mouse model;NADH dehydrogenase (ubiquinone);Neoplasm Metastasis;Outcome;overexpression;Pathway interactions;Patients;Pattern;Pre-Clinical Model;preclinical study;Production;protein expression;racial disparity;Recurrent disease;Research;Respiration;response;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Socioeconomic Status;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic evaluation;Tissues;transcriptomics;treatment response;tumor;tumor growth;tumor immunology;tumor progression;Tumor Promotion;tumor-immune system interactions;Tumor-infiltrating immune cells;tumorigenesis;Work;Xenograft procedure

PROJECT_TITLE: Decoding tumor metabolic and immunologic interactions driving racial disparity in African American patients with bladder cancer.

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE We do not know enough about how efficiently the spike proteins from diverse SARS-like beta coronaviruses need to bind with the ACE2 host cell receptor proteins encoded by different animals to successfully jump across host species and spark pandemic zoonotic spillovers. Using cutting-edge synthetic biology paired with multiplex infection assays, we will perform a series of large-scale genetic studies to reveal how differences in ACE2 protein sequence and cell surface expression levels interact with coronavirus spike protein sequences from various bat coronaviruses to understand how often each virus infects those cells. This molecular and genetic information will reveal which animals can serve as hidden reservoirs for potentially zoonotic SARS-like coronaviruses deserving heightened surveillance.

PI_NAMEs: MATREYEK, KENNETH A (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;Affinity;Africa;Amino Acid Sequence;Amino Acids;Animals;Arenavirus;Asia;Bar Codes;betacoronavirus;Binding;Biological Assay;Biology;Biotechnology;Catalogs;Cell surface;Cells;cellular engineering;Chiroptera;Complex;Computer Models;Coronavirus;Coronavirus spike protein;COVID-19 pandemic;cross-species transmission;Data;data access;Data Analyses;density;Disease Outbreaks;DNA sequencing;Europe;Event;experimental study;Family;Filovirus;Flow Cytometry;Future;future pandemic;Genetic;genetic information;Genetic study;Goals;Habitats;Health system;High-Throughput Nucleotide Sequencing;Human;improved;Infection;insight;Integration Host Factors;interest;Learning;Libraries;Light;luminescence;Machine Learning;Mammals;member;Merbecovirus;Methods;Modeling;Modernization;Molecular;mutant;mutation screening;Organism;Orthologous Gene;pandemic disease;Pattern;Plasmids;Play;Predisposition;prevent;Probability;Proteins;Public Health;receptor;receptor binding;Receptor Cell;Research Infrastructure;Role;Sampling;Sarbecovirus;SARS-CoV-2 spike protein;Series;Severe Acute Respiratory Syndrome;synthetic biology;Testing;Time;Tissues;tool;Training;Travel;Tropism;Variant;Viral;viral pandemic;Virus;Work;Zoonoses;zoonotic spillover

PROJECT_TITLE: Large-scale compatibility assessments between ACE2 proteins and diverse sarbecovirus spikes

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE “Understanding cancer and comorbidities among American Indian and Alaska Native people” is a two-year study which will use SEER-Medicare data to provide foundational data on the prevalence of comorbidities among AIAN people with cancer, and the impact that those comorbidities have on receipt of timely and guideline-concordant cancer care, and cancer survival. An exploratory aim will use Indian Health Service data to replicate analyses in a more geographically and demographically representative population, and determine whether IHS data are feasible to support population-based health services research to understand cancer care delivery among AIAN people. These data will provide critical information to understand causes of AIAN cancer disparities that can be used to drive future healthcare-based structural and programmatic interventions.

PI_NAMEs: NASH, SARAH  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Age;aged;Alaska Native;Alaska Native population;American Indian Population;American Indians;Cancer Burden;cancer care;cancer diagnosis;cancer health disparity;Cancer Patient;cancer site;cancer survival;Cancer Survivor;cancer therapy;care delivery;Caring;Cause of Death;Characteristics;Chronic;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Management;Colorectal;Communities;community engaged approach;comorbidity;comorbidity Index;Congestive Heart Failure;Coronary Arteriosclerosis;Data;Data Analyses;Data Set;data warehouse;Databases;Diabetes Mellitus;Diagnosis;Diagnostic;Dose;evidence base;experience;Female breast;flexibility;Future;Geography;Goals;Guidelines;Health Services Research;Health system;Healthcare;Hyperlipidemia;Hypertension;Incidence;Individual;information gathering;innovation;Interruption;Intervention;Kidney;Knowledge;Link;Lung;Malignant Neoplasms;Medicare;Minority Groups;Modeling;mortality;National Comprehensive Cancer Network;National Health Services;Neighborhoods;non-Native;Outcome;Outcomes Research;Patients;Play;Population;population based;Prevalence;Provider;Quality of life;Reporting;Research;Research Support;response;Role;rurality;Secondary to;Services;sex;Site;Socioeconomic Status;Staging;System;Time;treatment and outcome;treatment services;tribal health;underserved minority;United States Indian Health Service;Urban Health;Work


NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Narrative The proposed research will examine previously unknown cellular and molecular mechanisms in the multiple myeloma (MM) tumor microenvironment supporting disease progression and will produce important information to guide the development of novel therapeutic approaches to improve clinical outcomes in MM patients.

PI_NAMEs: BELLIDO, TERESITA M.;DELGADO-CALLE, JESUS  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: absorption;Alpha Cell;angiogenesis;Angiogenic Factor;Animal Model;Antibodies;autocrine;Autocrine Communication;Binding;bone;Bone Diseases;bone health;Bone Marrow;Bortezomib;Cell Communication;Cells;Clinical;clinical database;Coculture Techniques;Cytokine Receptors;data mining;design;Development;Dexamethasone;Disease;Disease Progression;Drug resistance;effective therapy;efficacy evaluation;Endocrine;fibroblast growth factor 23;Fibroblast Growth Factor Receptors;Foundations;fracture risk;Funding;Genes;Genetic;Goals;Growth;Growth Inhibitors;heparanase;Homeostasis;Human;improved;in silico;In Vitro;in vivo;inhibitor therapy;innovation;inorganic phosphate;Kidney;Knowledge;lenalidomide;Malignant - descriptor;Malignant Neoplasms;Marrow;Mediating;Mediator;Mining;Molecular;mouse model;Multiple Myeloma;Mus;Musculoskeletal;novel;novel therapeutic intervention;Osteocytes;Osteogenesis;Osteolytic;Outcome;paracrine;Paracrine Communication;Pathogenesis;Pathologic;Pathologic Neovascularization;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;Plasma Cells;Play;Proliferating;Proteasome Inhibitor;Quality of life;receptor;Refractory;Refractory Disease;Regimen;Relapse;relapse patients;repaired;Research;Resistance;response;Role;Serum;Signal Transduction;single-cell RNA sequencing;Source;stem;Stromal Cells;targeted treatment;Testing;therapy resistant;tool;TRANCE protein;treatment response;tumor;tumor growth;tumor microenvironment;VEGFA gene;Work;Xenograft procedure

PROJECT_TITLE: Contribution of osteocytes to the musculoskeletal effects of Multiple Myeloma

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE This project aims to demonstrate the effects of craniofacial reconstruction using an advanced biomaterial that has shown great promise in treating voice and speech disorders. Defining the long-term three-dimensional conformation changes and implant microenvironment of biomaterials within the posterior pharyngeal wall will help demonstrate the feasibility and durability of this approach in a preclinical model. This preliminary study will have broad implications for a potential clinical use in reconstructing the velopharyngeal mechanism. Achieving these goals will allow for additional preclinical modeling and development of precision medicine use cases.

PI_NAMEs: DANIERO, JAMES J. (contact);MASON, KAZLIN

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;absorption;Acute;Address;Advanced Development;Aerodigestive Tract;Affect;Aftercare;Anatomy;Animal Model;Biocompatible Materials;Biomedical Engineering;Blood Vessels;Calcium;care burden;Clinical;clinical application;Collaborations;Collagen;craniofacial;Data;Dermis;Detection;Durapatite;early childhood;Environment;Failure;Filler;Foreign-Body Reaction;Fostering;Functional disorder;Future;Gel;Goals;Growth;Hyaluronic Acid;Hydrogels;imaging science;Immune;immunogenicity;Implant;implantation;improved;In Situ;in vivo;Inflammation;inflammatory marker;Injectable;Injections;innovation;Light;Magnetic Resonance Imaging;manufacture;Methodology;Methods;Microspheres;migration;minimally invasive;Modeling;Modernization;Molecular Conformation;Movement;Muscle;next generation;novel;Operative Surgical Procedures;Oryctolagus cuniculus;Otolaryngology;Outcome;Outcome Assessment;particle;Patients;Pharyngeal structure;Physiology;Plastic Surgical Procedures;Porosity;Pre-Clinical Model;precision medicine;preclinical development;Procedures;reconstruction;Reporting;Research Personnel;respiratory morbidity;retention rate;Scientific Advances and Accomplishments;Second Look Surgery;Speech;Speech Disorders;Stains;success;Surgical Management;Technology;Time;tissue regeneration;Tissue Stains;Tissues;Vascularization;Visualization software;Voice Disorders

PROJECT_TITLE: Novel Implementation of Microporous Annealed Particle HydroGel for Next-generation Posterior Pharyngeal Wall Augmentation

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative This project is expected to determine the role of neuroendocrine dysfunction in primary hypertension, a dangerous clinical condition that afflicts 75 million people in the United States and may lead to stroke, heart disease, and renal failure. The proposed studies will greatly improve the understanding of the cellular and molecular mechanisms of the most common form of hypertension, primary hypertension, and should provide important information for developing new treatments to reduce high blood pressure.

PI_NAMEs: LI, DE-PEI  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Ablation;antagonist;Blood Pressure;blood pressure regulation;Brain region;Cardiovascular Diseases;Cardiovascular Physiology;Cause of Death;Clinical;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;Dangerousness;Data;designer receptors exclusively activated by designer drugs;Essential Hypertension;Functional disorder;Genetic;Glutamates;Heart Diseases;high risk;Hyperactivity;Hypertension;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;improved;Inbred SHR Rats;interdisciplinary approach;Kidney Failure;Mediating;Messenger RNA;Modeling;Molecular;mRNA Expression;N-Methyl-D-Aspartate Receptors;neuromechanism;Neurons;Neurosecretory Systems;novel;paraventricular nucleus;Patients;Persons;Pilot Projects;protein expression;Proteins;Rattus;Regulation;response;Risk Factors;Role;Source;Stroke;Synapses;Testing;treatment strategy;United States;Vasomotor

PROJECT_TITLE: Neuroendocrine dysfunction and hypertension

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Pregnancy;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Serious Mental Illness;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative A United States Preventive Services Task Force recommendation suggests that pregnant people at risk for depression be proactively engaged in behavioral health services. We will build an interpretable and acceptable algorithm for perinatal risk prediction that also addresses inequities in diagnosis and care provision. We will test the feasibility and acceptability of a scalable digital cognitive behavioral therapy tool for a diverse group of pregnant people identified as at risk for depression.

PI_NAMEs: KRISHNAMURTI, TAMAR  (contact)

PROGRAM_OFFICER_NAME: CHU, SERENA PO-LAN

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Algorithms;antepartum depression;arm;Artificial Intelligence;artificial intelligence algorithm;Behavior Control;behavioral health;Black Populations;Black race;Caring;Child;Childbirth;Clinical;clinical practice;Cognitive Therapy;community engagement;cost;Data;Data Set;depression prevention;Detection;Development;Developmental Delay Disorders;Diagnosis;digital;digital mental health;digital solutions;Discrimination;Disparity in diagnosis;Early Intervention;Effectiveness;Electronic Health Record;Enrollment;Ensure;Event;evidence base;Evidence based treatment;experience;Failure to Thrive;feasibility testing;Feedback;First Pregnancy Trimester;Frequencies;Funding;Future;graph learning;Health Services;High Risk Woman;human centered design;implementation framework;improved;Incidence;Individual;individual patient;Inequity;Infant;innovation;insight;Intervention;large datasets;learning algorithm;Light;Lived experience;Machine Learning;maternal depression;Measures;Medical center;Mental Depression;Mental Health Services;Methods;Modeling;Mothers;National Institute of Mental Health;Nurse Practitioners;Outcome Measure;Output;Participant;Pathway interactions;patient population;Patients;Perinatal;peripartum depression;Persons;Physicians;Population;Population Heterogeneity;Populations at Risk;Postpartum Period;Pregnancy;pregnant;Premature Birth;Prevention;Prevention approach;Prevention strategy;primary outcome;Process;prospective;Provider;Race;racial difference;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;recruit;Risk;Risk Factors;risk prediction;risk prediction model;routine care;Services;Societies;standard of care;tool;Touch sensation;treatment as usual;trial enrollment;United States Preventative Services Task Force;Universities;uptake;usability;Work

PROJECT_TITLE: Peripartum Depression Prevention: Algorithmic Identification and Digital Solutions


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lyme Disease;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: KANSAS CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Lyme borreliosis, caused by the spirochete Borrelia burgdorferi, remains the most common vector-borne disease in the United States with an estimated 300,000 cases each year. The proposed research will address how the bacterium secretes surface lipoproteins and generates its interface with the host. This may lead to the identification of new targets for prevention or treatment.

PI_NAMEs: ZUECKERT, WOLFRAM R (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Amino Acid Sequence;Architecture;ATP phosphohydrolase;ATP-Binding Cassette Transporters;Bacteria;Bacterial Proteins;Biological Process;Borrelia;Borrelia burgdorferi;Bypass;C-terminal;cell envelope;Cells;Complex;CRISPR interference;Data;diagnostic tool;dimer;Disease;emerging pathogen;Ensure;Eubacterium;Eukaryotic Cell;experimental study;Flagella;Gene Silencing;Genome;Gram-Negative Bacteria;Homologous Gene;improved;in silico;innovation;insight;Investigation;knock-down;Life Cycle Stages;Lipopolysaccharides;Lipoprotein (a);Lipoproteins;Lyme Disease;Mediating;Membrane;Membrane Proteins;model organism;Modeling;Modification;Molecular Conformation;monomer;mutant;Mutation;N-terminal;novel strategies;Order Spirochaetales;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Peptides;periplasm;Periplasmic Proteins;Physiological Processes;premature;Prevalence;prevent;Prevention;Prevention strategy;Process;Property;Protein Secretion;Proteins;Proteomics;Relapsing Fever;Research;Research Proposals;Role;routine Bacterial stain;Seminal;Serotyping;Site-Directed Mutagenesis;Sorting;Structural Models;Structure;Structure-Activity Relationship;Surface;System;Testing;tick-borne;Time;translocase;transmission process;United States;Vaccines;Variant;vector tick;Vector-transmitted infectious disease;Virulence Factors;X-Ray Crystallography

PROJECT_TITLE: Role of Borrelia Lpt Homologs in Surface Lipoprotein Secretion

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The Training Program in Signal Transduction and Cancer at the Robert H. Lurie Comprehensive Cancer Center at Northwestern University trains outstanding postdoctoral fellows in the discipline of cancer signaling through a structured curriculum of mentored laboratory research, seminars, symposia, coursework and professional development sessions and prepares them for careers in translational research that impacts patients with cancer.

PI_NAMEs: PLATANIAS, LEONIDAS C. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Malignant Neoplasms;Signal Transduction;Training Programs

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: EL PASO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: Program Director/Principal Investigator (Iñiguez, Sergio, Diaz): NARRATIVE Affective disorders are highly prevalent in the juvenile population. The dearth of preclinical models designed to evaluate the neurobiology of depression, in vulnerable populations specifically, limits our ability to uncover its pathophysiology. Thus, the goal of this proposal is to validate the vicarious defeat stress model for the examination of stress-induced illnesses in understudied populations, specifically adolescents and females. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: INIGUEZ, SERGIO DIAZ (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: abuse liability;Acute;Address;Adolescence;Adolescent;Adopted;Adult;Adult women;Affect;Affective;Age;Anhedonia;Animal Model;Animals;anti-depressive agents;Anxiety;Anxiety Disorders;Behavior;Behavior assessment;Behavioral;behavioral outcome;behavioral phenotyping;Biological Markers;Biological Models;Body Weight;Brain;Brain region;bullying;C57BL/6 Mouse;Childhood;Chronic;Chronic stress;Clinic;Clinical;Clinical Research;clinically relevant;Cocaine;comorbidity;Corticosterone;CREB1 gene;Data;Depressive disorder;depressive symptoms;Development;Diagnosis;Disease;Disparity;Drug abuse;drug seeking behavior;Epidemiology;Evaluation;Exclusion;Exhibits;experience;experimental study;Exposure to;FDA approved;Female;Female Adolescents;Fluoxetine;Functional disorder;Goals;Hippocampus;Impairment;Incidence;innovation;insight;Ketamine;Learned Helplessness;Lifestyle-related condition;Major Depressive Disorder;male;Male Adolescents;Mediating;Memory;Memory impairment;Mental Depression;model design;Modeling;Molecular;Molecular Target;Mood Disorders;Moods;Morbidity - disease rate;morris water maze;mortality;Mus;neurobiological mechanism;Neurobiology;neurochemistry;neurotropic;novel;Outcome Study;Performance;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;Physiological;Population;postnatal;pre-clinical;Pre-Clinical Model;Predisposition;preference;Principal Investigator;programs;Proteins;Proto-Oncogene Proteins c-akt;psychologic;Psychological Stress;Regulation;Reporting;response;Rewards;Risk Factors;Rodent;Rodent Model;Safety;sex;Sex Differences;Shapes;Signal Transduction;Signaling Molecule;Site;social defeat;social deficits;social exclusion;Social Interaction;spatial memory;Stimulus;Stress;Substance abuse problem;Sucrose;symptomatology;Symptoms;Tail Suspension;Validation;Vulnerable Populations;Woman

PROJECT_TITLE: Psychological stress susceptibility in juvenile female and male mice


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Nutrition;Obesity;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE The rising incidence in colorectal cancer (CRC) diagnosed under age 50 has resulted in updated guidelines from the American Cancer Society (ACS) advising average-risk screening begin at age 45, rather than 50. However, the etiology of early-onset CRC and contributors for this rise remain unclear. Our investigations into the role of mid-adulthood and early-life obesity, sedentary behaviors, and poor diet associated with risk of early-onset advanced adenoma as well as biomarker discoveries of both early-onset advanced adenoma/CRC will advance the understanding of the etiology of early-onset CRC and shed light on prevention. Our estimation of the explained portion of the rising incidence as well as the improvement of the simulations used to support the 2018 ACS screening guideline by incorporating meta-analyzed early-onset CRC specific risk factors/estimates will be a significant step forward toward optimal screening in younger adults.

PI_NAMEs: CAO, YIN  (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: adenoma;Adult;African American;Age;American Cancer Society;Archives;Bioinformatics;Biological Markers;biomarker discovery;Blood;cancer diagnosis;carcinogenesis;Carcinoma;circulating biomarkers;Clinical;Cohort Studies;Collaborations;Colon;colon carcinogenesis;colon tumorigenesis;Colorectal;Colorectal Cancer;colorectal cancer screening;Communities;cost;cost efficient;Data;Decision Modeling;Diabetes Mellitus;Diagnostic;Diet;Early Diagnosis;Early identification;early onset;early onset colorectal cancer;early onset colorectal neoplasm;emerging adult;Endotoxemia;Endotoxins;Epidemiology;Etiology;Guidelines;gut dysbiosis;High Fat Diet;Histology;human old age (65+);Immune response;improved;Incidence;Inflammation;Inflammatory Bowel Diseases;inflammatory marker;insight;Investigation;Life;Life course epidemiology;Life Cycle Stages;life span;Life Style;lifestyle data;lifestyle factors;Link;Measurement;Mediating;Meta-Analysis;microbial;Modeling;models and simulation;Molecular;multidisciplinary;Neoplasms;novel;novel marker;Nurses' Health Study;Obesity;Pathologic;Pathway interactions;personalized screening;Plasma;Play;Population;Positioning Attribute;Prevention;Process;prospective;Prospective cohort;protein protein interaction;Proteomics;Recommendation;Relative Risks;Reporting;Research Personnel;Research Priority;Resources;Risk;Risk Factors;Role;screening;screening guidelines;sedentary;sedentary lifestyle;simulation;systematic review;systemic inflammatory response;Testing;Time;Unhealthy Diet;Update;young adult

PROJECT_TITLE: Obesity, sedentary behaviors, and diet quality for prevention and early detection of early-onset colorectal neoplasia

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative:  1.6 million people suffer from opioid use disorder (OUD); opioid use has a high relapse rate, and is especially susceptible to overdose deaths, with >60% of deaths attributed to fentanyl. The transition from recreational/prescription to persistent opioid use and enhanced susceptibility to relapse is, in part, driven by enhanced endogenous opioid signaling in the brain, the maladaptive co-opting of existing reward-seeking strategies, and aberrant activity in the striatum, a brain region important for reward seeking. Therefore, the goal of this proposal is to refine and elucidate how enhanced opioid signaling alters neural circuit activity in the striatum during opioid-seeking.

PI_NAMEs: GOWRISHANKAR, RAAJARAM  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Address;Affect;Amygdaloid structure;Award;Behavior;Behavior Control;Behavioral Model;Biosensor;Brain;Brain region;Budgets;calmodulin-dependent protein kinase II;career;career development;Cessation of life;Committee Members;conditioning;Consumption;Corpus striatum structure;Cues;Data;Development;drug reward;Drug usage;Dynorphins;endogenous opioids;Fentanyl;fentanyl seeking;fentanyl self-administration;Fiber;Genetic;Goals;Head;Image;imaging approach;in vivo;in vivo calcium imaging;in vivo two-photon imaging;Intake;Internal Ribosome Entry Site;Intervention;kappa opioid receptors;Kinetics;knowledge base;Light;Link;Measures;Mediating;Mentors;Messenger RNA;National Institute of Drug Abuse;neural circuit;neuromechanism;Neurons;Neurosciences;novel;Operant Conditioning;Opioid;Opioid Antagonist;opioid use;opioid use disorder;optogenetics;Oral;overdose death;Pattern;Persons;Pharmaceutical Preparations;Pharmacology;Phase;Photometry;Population;Postdoctoral Fellow;Predisposition;preference;prevent;Principal Investigator;programs;Property;receptor expression;Receptor Signaling;Recreation;Regulation;Relapse;Research;Resolution;Rewards;Role;Scientific Societies;Self Administration;Shapes;Signal Transduction;substance use;Substance Use Disorder;Sucrose;symposium;Testing;Therapeutic Agents;Training;transmission process;two-photon;Validation

PROJECT_TITLE: Elucidating the role of the endogenous opioid dynorphin in reward seeking


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Precision Medicine;Prevention;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative Relevance to Public Health: Developing a non-invasive imaging test to predict which forms of an early breast cancer called ductal carcinoma in situ (or DCIS) are less aggressive would (1) address concerns that screening for breast cancer leads to detection of too much overdiagnosis of clinically insignificant breast cancer, (2) help to improve physicians’ ability to more clearly explain the long-term impact of DCIS diagnoses to patients and (3) identify which patients need aggressive treatment and identify those who will not benefit from unnecessary adverse side effects and expense associated with such therapies.

PI_NAMEs: KONTOS, DESPINA ;RAHBAR, HABIBOLLAH  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Address;Affect;Aftercare;aggressive therapy;American College of Radiology Imaging Network;angiogenesis;Anxiety;Biological;Biological Assay;Biology;biomarker validation;Breast;Breast Cancer Detection;breast cancer diagnosis;breast imaging;Breast Magnetic Resonance Imaging;calcification;cancer invasiveness;Classification;Clinical;Clinical Data;clinical database;clinical diagnosis;Clinical Markers;clinical prognostic;cohort;Collaborations;combat;Data;Databases;Detection;Development;Diagnosis;Disease;Eastern Cooperative Oncology Group;experience;Gene Expression;Genomics;health goals;Heterogeneity;high risk;Histopathology;hormone therapy;Image;imaging biomarker;improved;In Situ Lesion;Incidence;indexing;Individual;Institution;inter-institutional;Interobserver Variability;Invaded;Ipsilateral;Link;Local Therapy;Machine Learning;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Measures;Medical;Modeling;Molecular;molecular marker;Molecular Profiling;Morbidity - disease rate;MRI Scans;multidimensional data;Newly Diagnosed;Noise;non-invasive imaging;Noninfiltrating Intraductal Carcinoma;Normal tissue morphology;novel;novel strategies;Oncology;oncotype;open source;Operative Surgical Procedures;Outcome;overtreatment;Pathologic;Pathology;Patients;Penetration;Pennsylvania;Performance;phenomics;Phenotype;phenotypic data;Physicians;Prognosis;prognostic;Prognostic Factor;prognostic index;prognostic model;Proliferating;Public Health;Radiation therapy;radiomics;Radiosurgery;Recurrence;Reproducibility;Risk;Risk Assessment;risk prediction model;risk stratification;Sampling;Science;Semantics;side effect;Signal Transduction;software development;Staging;standard of care;Standardization;statistical center;Statistical Data Interpretation;Survival Rate;Systemic Therapy;Testing;Thick;Tissue Sample;Tissues;tool;treatment optimization;tumor;tumor heterogeneity;tumor microenvironment;Universities;Unnecessary Surgery;unsupervised clustering;user-friendly;Visualization;Washington;Woman;women's diagnosis;Work

PROJECT_TITLE: MRI Radiomic Signatures of DCIS to Optimize Treatment

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Study Narrative The proposed study moves an evidence-based culturally adapted treatment for addictions tested under controlled conditions in Project CAMI (Culturally Adapted Motivational Interviewing), to the real-world. Project Aims are to increase access to CAMI in a primary care setting to heavy drinking Latinxs and to evaluate CAMI's feasibility, acceptability, and effectiveness when delivered by clinical staff within this treatment delivery system. Our study is a first to test how to integrate culturally-adapted addiction treatments into primary care practice and will answer essential questions on implementing evidence-based care for Latinxs that can improve health disparities related to substance use while deepening understanding of how stressors (that are immigrant-specific or not) contribute to heavy drinking and drug use; findings may translate to the broader community to focus on population health for all primary care patients.

PI_NAMEs: LEE, CHRISTINA S (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Acculturation;addiction;Address;Adoption;Advocate;Aftercare;Alcohol consumption;alcohol related consequences;Alcoholic beverage heavy drinker;Alcohols;anxiety reduction;anxiety symptoms;arm;Caring;Client;Clinical;clinically significant;Collaborations;Communities;cost;Cost Analysis;depressive symptoms;Discrimination;drinking;Drug usage;Drug user;Effectiveness;effectiveness clinical trial;effectiveness/implementation design;effectiveness/implementation study;efficacious intervention;Enrollment;Ethnic Population;Evaluation;evidence base;experience;follow-up;Frequencies;Future;Goals;Health;health disparity;Heavy Drinking;Hybrids;illicit drug use;Immigrant;Immigration;implementation cost;implementation evaluation;implementation fidelity;implementation measures;implementation outcomes;implementation science;implementation strategy;improved;Individual;Intervention;Investigation;Knowledge;Latinx;Life;Measures;Mediator;Medical;Mental Health;Methods;minority stress;Modeling;motivational enhancement therapy;Needs Assessment;Outcome;Outcome Assessment;Patients;Persons;Pharmaceutical Preparations;Phase;Population;population health;Population Heterogeneity;Primary Care;primary care patient;primary care practice;primary care setting;Process;process evaluation;Proctor framework;Protocols documentation;Provider;Public Health;Qualitative Research;racial population;Randomized;randomized, clinical trials;Reduce health disparities;reduced substance use;Research;Research Design;Risk;Science;Signal Transduction;Social isolation;social stigma;social stressor;Stress;stressor;substance use;Supervision;System;Testing;Training;Translating;treatment as usual;Treatment outcome;treatment response

PROJECT_TITLE: Addressing Alcohol Use Related Health Disparities: A Hybrid Effectiveness Implementation Study of a Culturally Adapted MI for Latinx Alcohol and Drug Users

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cervical Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE This project aims to establish an academic-industrial partnership between Memorial Sloan Kettering Cancer Center and General Electric Healthcare to develop and disseminate advances in dynamic contrast-enhanced (DCE) MRI for use in cancer patients. The new developments, which include radial imaging, compressed sensing, and deep learning, will deliver rapid motion-resistant DCE-MRI with high spatial and temporal resolution for more accurate and reproducible quantification of MRI-derived metrics. The new technology to be disseminated as a prototype on GE scanners will promote the use of quantitative DCE-MRI biomarkers in clinical practice, a long-desired goal.

PI_NAMEs: AKIN, OGUZ ;OTAZO, RICARDO  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: advanced disease;Affect;Aftercare;Algorithms;anti-cancer research;Automation;Blood Vessels;Breathing;Cancer Patient;cancer type;chemoradiation;Chemotherapy and/or radiation;Clinical;clinical practice;Complex;contrast enhanced;convolutional neural network;Data;Data Set;deep learning;Development;Diagnostic Neoplasm Staging;Dimensions;Discipline of obstetrics;Disease;Drug Kinetics;Early treatment;Environment;Evaluation;experience;Generations;Goals;Guidelines;Gynecologic;Gynecology;Healthcare;Image;Image Analysis;Image Enhancement;image reconstruction;improved;improved outcome;individualized medicine;industry partner;insight;interest;International;Learning;Licensing;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Manufacturer;Maps;Memorial Sloan-Kettering Cancer Center;Methodology;Modeling;Monitor;Morphology;Motion;motion sensitivity;new technology;New York;novel;Patients;Perfusion;population based;Prediction of Response to Therapy;prototype;Qualitative Evaluations;Radial;reconstruction;Relapse;Reproducibility;Resistance;response;Speed;standard of care;success;T2 weighted imaging;Techniques;Technology;temporal measurement;Time;tool;Training;Translating;Translations;treatment response;Treatment Side Effects;tumor;tumor microenvironment;Tumor stage;Universities;Woman;women's treatment

PROJECT_TITLE: Rapid motion-robust quantitative DCE-MRI for the assessment of gynecologic cancers


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Fibrolamellar carcinoma, a life-threatening variant of liver cancer affecting adolescents and young adults, is characterized by a fusion event resulting in a novel chimeric protein that joins the N-terminal domain of DNAJ with the catalytic subunit of protein kinase A (PKAc). We aim to identify and validate druggable signaling networks that regulate the growth of DNAJ-PKAc fusion-expressing FLC cells. The knowledge gained from this study will accelerate the development of a novel therapeutic option for targeting childhood liver cancer.

PI_NAMEs: GUJRAL, TARAN SINGH (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Acceleration;Address;Adolescent and Young Adult;advanced disease;Affect;Binding;Biochemical;Biochemistry;Biological Assay;Biological Models;Biological Process;Cancer Model;candidate validation;Catalytic Domain;Cell Cycle;Cell division;cell growth;Cell Line;Cell Proliferation;Cell Survival;Cells;Centrosome;Chemoresistance;chemotherapy;Childhood Liver Cancer;Chimera organism;Chimeric Proteins;Clinical;clinical application;clinical candidate;clinical efficacy;Clinical Trials;Co-Immunoprecipitations;Collaborations;Colorectal Cancer;Complex;CRISPR/Cas technology;Cyclic AMP-Dependent Protein Kinases;Data;Death Rate;Development;Disease;Disease Resistance;druggable target;efficacy evaluation;Event;Excision;experimental study;Expression Profiling;Fibrolamellar Hepatocellular Carcinoma;follow-up;Gene Fusion;Generations;Genetic;genetic signature;Goals;Gravin;Growth;heat-shock proteins 40;Hepatocyte;Histology;Human;Immunofluorescence Immunologic;In Vitro;inhibitor;insight;irinotecan;kinase inhibitor;knock-down;Knowledge;Life;Ligase;Liver;Machine Learning;Malignant Epithelial Cell;Malignant neoplasm of liver;Mitosis;Mitotic;Modeling;Molecular;Mus;N-terminal;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Oral;Pathogenesis;patient derived xenograft model;Patients;pharmacologic;Pharmacology;Pharmacotherapy;Phenotype;Phosphotransferases;PLK1 gene;polo-like kinase kinase 1;Pre-Clinical Model;preclinical trial;Property;Protein Array;Proteins;research clinical testing;Research Personnel;Resistance;response;RNA Interference;Role;screening;Signal Transduction;Slice;stem;System;Systems Biology;targeted treatment;Testing;Therapeutic;Tissues;trait;tumor;tumor growth;tumor progression;Tumor Weights;Up-Regulation;Variant;Work

PROJECT_TITLE: Targeting PLK1 signaling for the treatment of fibrolamellar carcinoma


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: WELLESLEY

ORG_NAME: BABSON COLLEGE

PHR: PROJECT NARRATIVE Babson Life Sciences Entrepreneurial Product Development Immersion for New Technologies and Solutions (Babson L-SPRINT) Program Biomedical entrepreneurship and health-related entrepreneurship at large is recognized as central to improving health outcomes, economic development, and societal well-being. Yet commercialization and technology-based start-ups can be challenging in an academic environment due to varying reward structures, organizational structures, organizational cultures and a lack of entrepreneurial education to bridge the gap between basic science and commercialization. The Babson L-SPRINT program will develop, recruit participants for, and deliver a specialized entrepreneurial education curriculum highlighting Babson’s signature Entrepreneurial Thought & Action® offering coupled with customized health and biomedical entrepreneurship content on addressing market segmentation and uncertainty, commercializing emerging technologies, scaling for growth, and interactive biomedical community building experiences.

PI_NAMEs: GLOVER, WILJEANA  (contact);ONYEMAH, VINCENT ;RANDOLPH, ANGELA

PROGRAM_OFFICER_NAME: LUKACS, JESSICA MICHELLE

PROJECT_TERMS: Active Learning;Address;Basic Science;Biological Sciences;Businesses;college;commercialization;Communities;community building;Coupled;curriculum development;Decision Making;Development;Devices;Diagnostic Equipment;Drug Addiction;Economic Development;Education;Educational Curriculum;Electronic Mail;Emerging Technologies;Entrepreneurship;Environment;experience;Faculty;Future;Goals;Growth;Health;Healthcare;Immersion;improved;Individual;Industry;innovation;Intellectual Property;interest;Marketing;Mechanics;Mobile Health Application;National Institute of Drug Abuse;Neurosciences;new technology;Newsletter;Organizational Culture;organizational structure;Outcome;outreach;Participant;Patient Recruitments;Personal Satisfaction;Pharmaceutical Preparations;product development;programs;Public Health;recruit;Research;Research Personnel;Rewards;Role;Scientist;skill acquisition;Structure;Substance Use Disorder;substance use treatment;symposium;Techniques;Technology;Therapeutic;Thinking;tool;Training;Uncertainty;United States;United States National Institutes of Health;Work


NIH_SPENDING_CATS: Biotechnology;Charcot-Marie-Tooth Disease;Clinical Research;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Peripheral Neuropathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Genome editing technologies are poised to revolutionize the practice of modern medicine for the treatment of genetic diseases. Novel strategies are needed to address the diversity of dominant genetic mutations that cause severe neurodegenerative diseases. The primary objective of this proposal is to develop and validate multiple therapeutic gene editing approaches for dominant motor neuron diseases, using human induced pluripotent stem cell models of Charcot-Marie-Tooth type 2E as a test case.

PI_NAMEs: JUDGE, LUKE M (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: 3-Dimensional;Address;Affect;Alleles;Animal Model;Animals;Axon;Biological Assay;Cells;Charcot-Marie-Tooth Disease;Chromatin Structure;clinical application;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Computer software;CRISPR/Cas technology;Data;design;digital;disability;Disabling;Disease;disease phenotype;DNA;dominant genetic mutation;Dominant-Negative Mutation;effective therapy;efficacy testing;Elements;Epigenetic Process;Excision;Exons;Foundations;Frequencies;Future;gene editing technology;Gene Expression;gene-editing approach;Genes;Genetic;Genetic Diseases;Genetic Enhancer Element;genome editing;genomic locus;Goals;Hereditary Motor and Sensory-Neuropathy Type II;Heterozygote;Human;human induced pluripotent stem cells;In Vitro;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Inherited;Light;loss of function mutation;Maps;Measurement;Mediating;Methods;Modeling;Modern Medicine;Motor Neuron Disease;Motor Neurons;Mutagenesis;mutant;Mutation;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;neurofilament;Neuronal Differentiation;novel strategies;Nucleic Acid Regulatory Sequences;Nucleotides;Outcome;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Persons;Phenotype;Population;Positioning Attribute;preclinical development;prevent;promoter;Proteins;Rare Diseases;Reagent;Recovery of Function;Regulatory Element;Reporter;Reporting;Risk;Safety;Site;Specificity;Spinal;Spinal Degenerative Disorder;stem cell model;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapeutic genome editing;Translating;treatment strategy;Untranslated RNA;Variant

PROJECT_TITLE: Allele-specific inactivation for dominant negative NEFL Mutations

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project narrative Human norovirus is the leading cause of viral gastroenteritis globally causing up to 200,000 deaths each year; however, it is unknown how norovirus establishes infection and causes disease. We recently discovered that murine norovirus, a model for human norovirus, infects rare intestinal cell called tuft cells which are critical for combating worm infection. In this project, we will identify how norovirus kills tuft cells, whether infection impairs tuft cell function, and how infection of tuft cells enables norovirus to evade the immune response.

PI_NAMEs: WILEN, CRAIG BRIAN (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;Adaptive Immune System;Adoptive Transfer;Adult;allergic response;Animals;Anti-viral Agents;antigen detection;Antigen Presentation;Bacteria;Binding;Biological Models;CD8-Positive T-Lymphocytes;Cell Culture System;Cell Culture Techniques;cell killing;Cell Physiology;cell type;Cells;Cellular Immunity;Cessation of life;Child;Chronic;chronic infection;Coculture Techniques;Colitis;Complex;conditional knockout;Data;Detection;Disease;Enteral;enteric virus infection;Epithelial Cells;Food Hypersensitivity;Gastroenteritis;Gastrointestinal tract structure;Genes;Genetic;Goals;gut inflammation;gut microbes;Helminths;Human;Immune;Immune Evasion;immune function;Immune response;Immune system;Immunity;Immunologics;Impairment;In Vitro;in vivo;Infection;Inflammatory Bowel Diseases;insight;Interferons;Intestines;Knock-in Mouse;Knockout Mice;Link;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;microbiome;Modeling;Mucosal Immune System;Mucosal Immunity;Mucous Membrane;Mus;Nematoda;nerve supply;Neurons;Norovirus;novel;Organoids;Pathogenesis;Pathologic;Population;Predisposition;prevent;Property;Protozoa;receptor;resident commensals;Resistance;Role;Sensory;Signal Transduction;single-cell RNA sequencing;T-Lymphocyte;Testing;Time;tool;transcriptome;transmission process;Tropism;vaccine development;Vaccines;Viral;Viral Gastroenteritis;Virus;Virus Diseases;virus genetics;Work;wound healing

PROJECT_TITLE: The role of tuft cells in norovirus pathogenesis

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative Immunotherapies have become crucial treatment options for a variety of cancer types and several novel targets are currently being explored to evaluate their anti-tumor capacity. Crucially however, most of these targets suffer from on-target, off-cell effects, as other immune cell types can express high levels of these molecules or induce widespread toxicity in non-malignant organs, severely limiting viable treatment options. The proposed study will elucidate the anti-tumor effects of TFR cells, a novel cellular immunotherapy target, and test ways to target them more specifically to induce long-lasting anti-tumor responses without causing irAEs.

PI_NAMEs: ESCHWEILER, SIMON  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Adoptive Transfer;Affect;anti-CTLA4;anti-PD1 therapy;Antibodies;Antigens;antitumor effect;Antitumor Response;ATAC-seq;Automobile Driving;cancer immunotherapy;cancer type;CD8-Positive T-Lymphocytes;cell type;Cells;Cellular immunotherapy;cellular targeting;chromatin immunoprecipitation;cohort;Colitis;Colon;Combined Modality Therapy;CTLA4 gene;Data;Development;DNA Binding;Dose;draining lymph node;Enhancers;Epithelial Cells;Evaluation;Exhibits;Frequencies;gastrointestinal epithelium;Gene Expression Profile;Generations;Genes;genetic approach;Genetic Engineering;Genetic Transcription;Half-Life;Human;Immune;immune checkpoint blockade;immune-related adverse events;Immunology;immunoregulation;Immunosuppression;Immunotherapy;Impairment;improved;in vivo;Infiltration;inhibitor;insight;keratinocyte;Link;Maintenance;Malignant Neoplasms;Melanoma;Modeling;Molecular;mouse model;Mus;Nature;Neoadjuvant Therapy;neoantigens;Non-Malignant;novel;Organ;Pathogenicity;Pathway interactions;Patients;pharmacologic;phase II trial;Phosphatidylinositols;Phosphotransferases;Placebo Control;precursor cell;Primary Neoplasm;programmed cell death protein 1;programs;Property;protein expression;Randomized;Regimen;Regulatory T-Lymphocyte;response;Role;secondary lymphoid organ;selective expression;single cell ATAC-seq;single-cell RNA sequencing;Skin;Solid;Solid Neoplasm;standard care;stem;survival outcome;T cell response;T-Lymphocyte Subsets;targeted treatment;tertiary lymphoid organ;Testing;Therapeutic;therapy development;Tissues;Toxic effect;transcription factor;transcriptomics;Translating;Treatment Efficacy;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Tissue

PROJECT_TITLE: Evaluation of T follicular regulatory cells as novel cellular targets of cancer immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Itis estimated thatfibrosiscontributes to 45 percent of alldeathsin the developed world. Fibrosis is the end result of chronic inflammatory reactions induced by a variety of stimuli including persistent infections, autoimmune reactions, allergic responses, chemical insults, radiation, and tissue injury. The project aims to understand the role cytosolic pathogen sensing pathways in fibrosis.

PI_NAMEs: SUSZTAK, KATALIN  (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: allergic response;Autoimmune;B-Cell Activation;Binding;cell type;Cells;Cessation of life;Chemicals;chemokine;Chronic;chronic infection;Chronic Kidney Failure;Clinical;Cultured Cells;Cyclic GMP;cytokine;Cytosine;Data;defined contribution;Dendritic Cells;Development;Disease;DNA;DNA Transposable Elements;Endogenous Retroviruses;Endothelial Cells;Enhancers;Epithelial Cells;Epithelium;Extravasation;Fibrosis;Financial Hardship;Genes;Genetic;Genetic Predisposition to Disease;Genetic Transcription;genetic variant;Genets;genome wide association study;Histologic;Human;Human Genetics;In Vitro;Infection;Inflammation;Inflammatory;Injury;Injury to Kidney;IRF3 gene;Kidney;kidney cell;Kidney Diseases;kidney fibrosis;Knowledge acquisition;Light;Lymphoid;Maps;Medicine;Methylation;Mitochondria;Mitochondrial DNA;mouse model;Mus;Myelogenous;Myeloid Cells;NF-kappa B;novel;Nuclear;Nucleotides;pathogen;Pathogenesis;Pathway interactions;Patients;Pattern recognition receptor;pharmacologic;Phosphotransferases;Play;Production;Radiation Injuries;Reaction;receptor;receptor expression;Renal tubule structure;RNA;Role;Sampling;sensor;Severity of illness;Signal Transduction;Stimulator of Interferon Genes;Stimulus;T-Lymphocyte;TBK1 gene;therapeutic development;tissue injury;TLR3 gene;transcription factor;TREX1 gene;TRIM Gene;Wit

PROJECT_TITLE: The role of cytosolic nucleotide sensors in inflammatory fibrosis

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The Stanford Training Program in Lung Biology offers a rigorous and supportive environment for physician scientists, with a focus on selecting qualified T32 Trainee candidates, optimizing their pairing with a committed Mentor and supporting their education and scientific development throughout their training. Trainees will select from an established group of Mentors in nine areas of particular excellence at Stanford (vascular disease, stem cells/development, genetics/genomics, lung injury/repair, immunology, microbiome, outcomes research, cancer, and imaging) to prepare for successful careers in biomedicine.

PI_NAMEs: CORNFIELD, DAVID N.;NICOLLS, MARK ROBERT (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Biology;Lung;Training Programs

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: Newark

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Project Narrative Obesity and diabetes are very common metabolic disorders linked to brain dysfunction. Glucagon-like peptide- 1 (GLP-1) analogs reduce food intake in humans, and this is an FDA-approved drug for treating type 2 diabetes that is also approved for weight loss in treating obesity; however, their mechanism for suppression of food intake is unclear. Addressing the central control of GLP-1 on feeding behavior will not only help us understand the functions of neuropeptides in the brain but will also inform the pharmacotherapy of obesity.

PI_NAMEs: PANG, ZHIPING P. (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Address;Affect;Agonist;Aminobutyric Acids;analog;Animals;Behavior;Body Weight decreased;Brain;brain dysfunction;Cell Nucleus;cell type;Central Nervous System;Clinical;Complex;Data;Development;Diabetes Mellitus;dorsal motor nucleus;Eating;Eating Behavior;Eating Disorders;Electrophysiology (science);energy balance;Energy Metabolism;Experimental Designs;FDA approved;feeding;Feeding behaviors;Feeding Patterns;Fiber;Food;Food Access;G-Protein-Coupled Receptors;genetic approach;GLP-I receptor;glucagon-like peptide 1;Glutamates;Goals;hedonic;Heterogeneity;Homeostasis;Human;Hyperphagia;In Situ Hybridization;individualized medicine;insight;interdisciplinary approach;Intervention;Lateral Hypothalamic Area;Link;Mediating;Metabolic Diseases;Metabolism;Molecular;Monitor;Motivation;Mus;Nervous System control;neurochemistry;neuronal excitability;Neurons;Neuropeptides;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity treatment;optical sensor;paraventricular nucleus;Pathway interactions;Pattern;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Photometry;Physiological;Play;Population;receptor;redshift;reduced food intake;Reporter;Rewards;Role;Signal Transduction;Structure of terminal stria nuclei of preoptic region;Subgroup;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;tool;transmission process;Vagus nerve structure;Work

PROJECT_TITLE: Synaptic and circuit mechanisms of central GLP-1 signaling in energy balance

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE The vestibular system plays a key role in our ability to move and interact with the world, by supporting balance, posture, and the stabilization of vision during movements of the head and body. This project will provide insights about the computations neural circuits perform on vestibular signals to guide movements, and how those computations are tuned by learning. The results will build a foundation to guide the development of new approaches for treating balance disorders.

PI_NAMEs: GOLDMAN, MARK S;RAYMOND, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: adaptive learning;Address;Behavior;Behavior Control;behavior test;Behavioral;Calibration;Cerebellum;Clinical;Code;Color;Complex;Computer Models;computerized tools;Darkness;Data;density;design;Development;Dissociation;Electrophysiology (science);Elements;equilibration disorder;Equilibrium;experience;Eye Movements;Feedback;Fiber;Foundations;Future;Head Movements;improved;in vivo;insight;Learning;Linear Models;Maps;medial vestibular nucleus;Mediating;Methods;Modeling;Modification;Molecular;Motor;motor learning;Movement;Mus;Nervous System;neural;neural circuit;Neuronal Plasticity;Neurons;neurotransmission;Noise;novel strategies;operation;optogenetics;Output;Play;Posture;Procedures;Process;Protocols documentation;Purkinje Cells;Recovery;Recurrence;Research;response;Role;Sensory;sensory input;Shapes;signal processing;Signal Transduction;Site;Source;Statistical Data Interpretation;Stimulus;Synapses;System;Testing;Vestibular Diseases;Vestibular function;vestibular system;vestibulo-ocular reflex;Vision;Visual;visual control;Work

PROJECT_TITLE: Vestibular and Visual Control of Eye Movement

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]