FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Overall Component Project Narrative The NE-INBRE is designed to increase the biomedical research and training capacity at institutions of higher education and contribute to the development of the scientific workforce in the state. Primarily undergraduate institutions receive funding to enhance their faculty research and establish modern laboratories, thus providing opportunities for undergraduate students to engage in modern research and consider entering a career in research and/or the health professions. Research universities receive funding to support the development of multiuser core facilities that make cutting edge technology available to research programs on these campuses.

PI_NAMEs: SORGEN, PAUL L (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Academic Medical Centers;Achievement;Advisory Committees;Area;Arts;Attitude;Award;Benchmarking;Bioinformatics;Biomedical Research;Cancer Biology;career;career development;Collaborations;college;Communicable Diseases;Contracts;Core Facility;design;Development;Doctor of Philosophy;Educational Curriculum;effectiveness evaluation;Evaluation;Evaluation Reports;experience;Faculty;faculty research;faculty support;Feedback;functional genomics;Funding;Genomics;Goals;graduate student;Grant;Guidelines;Health Occupations;higher education;Infrastructure;Institution;interest;Investments;Knowledge;Laboratories;Leadership;Left;Link;Measures;Medical center;meetings;member;Mentors;Microscopy;Mission;Modernization;multidisciplinary;Nebraska;Network-based;organizational structure;Outcome;Peer Review;Perception;Policies;Privatization;Productivity;Program Research Project Grants;programs;Publications;recruit;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Resource Sharing;Saints;satisfaction;Scholars Program;Schools;Science;Signal Transduction;Structure;Students;success;Surveys;System;Technology;Training;undergraduate research;undergraduate research experience;undergraduate student;Universities

PROJECT_TITLE: Nebraska Research Network in Functional Genomics


ADMINISTERING_IC: HG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The purpose of this project is to create a nucleotide-resolution cis-regulatory map of the human genome to connect disease variants to functions and phenotypes, in collaboration with the IGVF Consortium. We will use our new methods to help interpret common and rare genetic variation, and to identify variants that may contribute to disease. Outputs from the project will include new computational methods, open-source software, and publicly available cis-regulatory maps for diverse cell types.

PI_NAMEs: KUNDAJE, ANSHUL  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Algorithms;Atlases;base;Beds;Binding;Biological Assay;Brain;Cardiac Myocytes;Catalogs;causal variant;cell type;Cells;Chromatin;Chromatin Modeling;Code;cohort;Collaborations;combinatorial;Communities;Complex;Computer software;Computing Methodologies;Data Collection;data-driven model;de novo mutation;deep learning;deep learning model;design;Disease;disease phenotype;disorder risk;diverse data;DNA Sequence;Elements;Enhancers;Ethnic Origin;experimental study;Fetal Heart;functional genomics;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Frequency;Genes;Genetic;Genetic Models;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;Genomics;Goals;histone modification;Human;Human Genetics;Human Genome;human genomics;improved;in silico;Individual;lens;machine learning method;machine learning model;Maps;Methods;Modeling;Molecular;Molecular Disease;molecular phenotype;neural network;next generation;Nucleotides;open source;Output;outreach;Performance;Phenotype;polygenic risk score;portability;predictive modeling;programs;promoter;Quantitative Trait Loci;Rare Diseases;Regulator Genes;Regulatory Element;Reproducibility;Research;Research Personnel;Resolution;single cell genomics;single cell technology;spatiotemporal;syntax;Testing;Time;transcription factor;Untranslated RNA;Validation;Variant;Vision;working group

PROJECT_TITLE: Predicting context-specific molecular and phenotypic effects of genetic variation through the lens of the cis-regulatory code


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Address;Advisory Committees;Area;Award;Benchmarking;Bioinformatics;Biomedical Research;Cancer Biology;career;Centers of Research Excellence;Collaborations;college;Committee Members;Computer software;conflict resolution;Core Facility;design;Development;Direct Costs;Education;Educational workshop;Electronics;Ensure;Environment;Evaluation;experience;Faculty;faculty mentor;First Independent Research Support and Transition Awards;Foundations;functional genomics;Grant;improved;Individual;Infrastructure;insight;Institution;instrumentation;interest;Journals;laboratory experiment;Leadership;Libraries;meetings;member;Mentors;Methods;Microscopy;Monitor;Nebraska;Policies;Positioning Attribute;Principal Investigator;Program Research Project Grants;programs;Protocols documentation;Qualifying;recruit;Research;Research Activity;Research Infrastructure;Research Institute;Research Project Grants;Resource Allocation;Role;Saints;Scholars Program;Science;Series;skills;Structure;Students;summer research;symposium;tool;Training;training opportunity;undergraduate research;undergraduate research experience;undergraduate student;United States National Institutes of Health;Universities;web site


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: GUDA, CHITTIBABU  (contact)

PROJECT_TERMS: Adopted;Algorithms;Area;Bioinformatics;bioinformatics infrastructure;bioinformatics resource;Biomedical Research;Cells;CLC Gene;cluster computing;Collaborations;Collection;Communities;Computer Analysis;computer infrastructure;Computer software;Computing Methodologies;Custom;Data;data access;Data Analyses;data analysis pipeline;Data Set;Data Storage and Retrieval;Databases;Development;Distance Education;Education;Education and Outreach;Educational process of instructing;Educational workshop;Environment;Epigenetic Process;experience;flexibility;functional genomics;Funding;fusion gene;Future;Genome;genomic data;Genomics;Goals;Grant;High Performance Computing;high throughput technology;Human;Individual;Infrastructure;Institution;Journals;large scale data;Licensing;Location;meetings;member;Mentors;Metagenomics;microbiome;Molecular;multiple omics;Nature;Nebraska;next generation sequencing;online course;Organism;outreach;outreach program;Participant;Pathway Analysis;Process;Proteomics;public database;Public Domains;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Schedule;Services;simulation;single cell sequencing;Snakes;Source;Statistical Methods;Structure;success;Technical Expertise;Techniques;Technology;Teleconferences;Testing;tool;Training;transcriptomics;undergraduate student;Update;Viral;virtual machine;Work


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Networking and Information Technology R&D (NITRD);Patient Safety;Rare Diseases

ORG_CITY: TALLAHASSEE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Relevance: This research aims to develop and validate a technology that will help medical trainees practice their skills using afforable and widely available head-mounted displays for an emerging minimally-invasive procedure for robotic head and neck surgeries. A well-established and safe commercially available neurostimulation device will be used to help the trainees improve their performance. The proposed stimulated simulation training methodology will allow clinicians to learn the procedure in a risk-free manner on computers before application to patients, resulting in lower errors, improved patient outcomes, and reduced treatment costs.

PI_NAMEs: DE, SUVRANU  (contact);GOMEZ, ERNEST DENNIS;SHAFI, MOUHSIN

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: 3-Dimensional;Acceleration;Active Learning;Address;Adoption;Anatomy;Auditory;Automobile Driving;Aviation;Benchmarking;Benign;body cavity;Cerebral cortex;Clinical;clinical training;Cognitive;cognitive skill;Complex;Computer Models;Computers;Confined Spaces;Control Groups;Conventional Surgery;cost;Cues;Depth Perception;design;Development;Devices;Dissection;Educational Curriculum;Electrocoagulation;Environment;Excision;experience;experimental study;Exposure to;FDA approved;Feedback;Fellowship;Fistula;Functional impairment;functional outcomes;Future;Goals;Head and Neck Surgeon;Head and Neck Surgery;head mounted display;Hour;Impaired healing;improved;instrument;Interdisciplinary Study;Intuition;Jaw;Laryngeal neoplasm;Larynx;Learning;Learning Skill;lens;Lesion;Malignant - descriptor;Malignant neoplasm of pharynx;malignant oropharynx neoplasm;Medical;Methodology;minimally invasive;Music;noninvasive brain stimulation;novel;Obstructive Sleep Apnea;open source;Operative Surgical Procedures;Oral;Oral cavity;Oropharyngeal;Osteoradionecrosis;Otolaryngology;Participant;patient safety;Patient-Focused Outcomes;Patients;Performance;Pharyngeal structure;Physics;Physiological;platform-independent;Procedures;Recovery;Research;Research Personnel;Research Project Grants;Resected;Residencies;Resolution;Risk;Robotics;Scalp structure;simulation;simulation environment;simulation software;skill acquisition;skills;skills training;Speed;Sports;Standardization;Structure;success;Surgeon;task analysis;Task Performances;Techniques;Technology;Time;Tissues;tongue root;tool;Training;transcranial direct current stimulation;transfer learning;Treatment Cost;tumor;Variant;virtual;virtual reality;virtual reality simulator;Vision;Visual;wearable device;Work;wound;Wrist

PROJECT_TITLE: Enhancing robotic head and neck surgical skills using stimulated simulation

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PI_NAMEs: EUDY, JAMES  (contact)

PROJECT_TERMS: Area;Automobile Driving;Basic Science;Biological Assay;biological research;Biomedical Research;career;Cells;college;Communities;Core Facility;Development;DNA sequencing;Doctor of Philosophy;exome;Faculty;functional genomics;Funding;Genes;genome sequencing;Genomics;graduate student;High School Student;higher education;Infrastructure;Institution;instrumentation;interest;Laboratories;lectures;Medical center;meetings;Mentors;Metagenomics;Methods;miRNA expression profiling;Mission;mRNA sequencing;Nebraska;New Mexico;next generation;Occupations;Organism;Phase;Population;Procedures;programs;rapid growth;Research;Research Institute;Research Personnel;Resources;Ribosomes;RNA;Science;Scientific Advances and Accomplishments;Services;single cell genomics;Source;spelling;Students;targeted sequencing;Technology;Tissues;Training;transcriptome sequencing;undergraduate student;United States National Institutes of Health;Universities;Update;whole genome


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: CAPLAN, STEVEN H (contact)

PROJECT_TERMS: Academic Medical Centers;Awareness;biomedical imaging;Biomedical Research;cell fixing;Confocal Microscopy;Consultations;Core Facility;Data;data acquisition;Data Analyses;Development;Doctor of Philosophy;Effectiveness;Equipment;Experimental Designs;functional genomics;Funding;Goals;Grant;Health;higher education;Image;imaging facilities;Imaging Techniques;improved;Institution;instrumentation;Investments;Joints;light microscopy;Lighting;Medical center;medical schools;Methodology;Microscopy;Mission;Modernization;molecular imaging;multi-photon;nanometer;Nebraska;Optics;outreach;Play;Publications;Qualifying;reconstruction;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;Role;Science;Scientist;Services;single molecule;skills training;Specialist;Structure;superresolution microscopy;System;Techniques;Technology;Tissues;Training;training opportunity;ultra high resolution;Universities


PROJECT_TERMS: Advisory Committees;Area;Award;Biomedical Research;Budgets;Cancer Biology;career;Career Choice;career development;Career Mobility;Centers of Research Excellence;Collaborations;Committee Members;Communicable Diseases;Communication;Development;Developmental Process;Eligibility Determination;Environment;Equipment;Equipment and Supplies;Evaluation;expectation;experience;Faculty;faculty support;functional genomics;Funding;Funding Opportunities;Goals;Grant;Guidelines;Health;Health Occupations;Health Professional;Institution;Journals;Laboratories;Link;meetings;member;Mentors;Monitor;Nebraska;Outcome;Peer Review;Process;Program Research Project Grants;programs;Regulation;Research;Research Activity;Research Proposals;Resources;Safety;Scholars Program;Science;Science, Technology, Engineering and Mathematics;senior faculty;Signal Transduction;skills;STEM field;Students;success;symposium;Time;timeline;tool;Travel;undergraduate student;United States National Institutes of Health


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Relevance Statement: The continued epidemics of HIV, tuberculosis, SARS CoV-2 and other infections of major public health importance indicate a substantial need for translational science researchers who can bridge infectious disease epidemiology and pathogenesis research.

PI_NAMEs: KALAMS, SPYROS A (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Vanderbilt Infection Pathogenesis and Epidemiology Research Training Program

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE  The Pathways Study is a multi-ethnic prospective cohort study of women diagnosed and treated for breast cancer in the Kaiser Permanente Northern California (KPNC) integrated health care system that is designed to examine multi-level factors to improve the breast cancer experience and outcomes. The study includes patient-reported health and lifestyle behaviors such as food intake, physical activity, and quality of life; molecular and genetic factors from blood specimens; a tumor bank; clinical factors from electronic health records; neighborhood factors from geospatial databases and virtual neighborhood audits; and a Community Advisory Board to help guide infrastructure activities and prioritize research use of this cohort. We propose to enhance this resource in various ways, including continued follow-up, new data linkages with environmental exposure and statewide health care utilization data, and with creation of a complementary data-only cohort of women diagnosed with breast cancer in KPNC from 2006 to 2023, thus cementing this resource as the outstanding setting for epidemiologic studies of breast cancer survivorship and outcomes.

PI_NAMEs: AMBROSONE, CHRISTINE B.;KUSHI, LAWRENCE H (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Accident and Emergency department;Address;African American;Air;Aliquot;Alternative Therapies;Ambulatory Surgical Procedures;Ancillary Study;Asian Women;Behavior;biobank;Biological Assay;Biological Specimen Banks;Blood;Blood specimen;bone health;breast cancer diagnosis;Breast Cancer survivorship;Breast Cancer Treatment;built environment;California;cancer care;cancer invasiveness;Cancer Prognosis;cancer therapy;Cardiovascular Diseases;care systems;Cementation;Cessation of life;Characteristics;chemotherapy;Clinical;cohort;Cohort Studies;Communication;Communities;community advisory board;comorbidity;Complement;Complementary therapies;Comprehensive Cancer Center;cost;Data;data enclave;Data Linkages;data resource;Databases;design;Diagnosis;Diagnostic;dietary supplements;Dimensions;DNA;DNA Microarray Chip;Dose;Eating;Electronic Health Record;Emergency department visit;Enrollment;Environment;Environmental Exposure;Epidemiology;epidemiology study;ethnic diversity;Event;experience;follow-up;Formalin;Genetic;genome-wide;Germ Lines;Health;health care service utilization;health plan;Healthcare;Healthcare Systems;Hereditary Disease;Hospitalization;improved;Infrastructure;Infrastructure Activities;innovation;Institution;Integrated Health Care Systems;Latina;Life Style;lifestyle factors;Link;Malignant Breast Neoplasm;Management Information Systems;Measures;Medical;member;Molecular;multi-ethnic;Neighborhoods;Operative Surgical Procedures;Outcome;Paraffin Embedding;Participant;Pathologic;Pathway interactions;Patient Self-Report;patient-clinician communication;Patients;Pharmaceutical Preparations;Physical activity;Plasma;programs;Prospective Studies;Prospective, cohort study;Quality of life;Questionnaires;racial diversity;Recurrence;Reporting;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;Saliva;saliva sample;Serum;Slide;Social Environment;Social Network;Social support;Specimen;Time;Tissue Microarray;Toxic effect;Treatment Protocols;tumor;Tumor Bank;United States National Institutes of Health;Update;virtual;water quality;web portal;Whole Blood;Woman;Women's cohort;women's diagnosis

PROJECT_TITLE: Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Complementary and Integrative Health

ORG_CITY: SAN JOSE

ORG_DEPT: CHEMISTRY

ORG_NAME: SAN JOSE STATE UNIVERSITY

PHR: Narrative This project proposes to understand the nuanced nature of SIRT1 regulation by small molecules and by its own regulatory domains. The findings will provide crucial information to help evaluate off-target effects for SIRT1-targeting therapeutics and to clarify regulation of SIRT1 within the cell. The knowledge gained here can also shed light on the mechanism for regulation of other multidomain post-translational modification enzymes, many of which are integral to human health.

PI_NAMEs: WANG, NINGKUN  (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: Affect;Affinity;Allosteric Regulation;Alzheimer's Disease;Binding;Binding Sites;Biochemical;Biochemistry;Biological;Biological Assay;C-terminal;Catalytic Domain;Cell Culture Techniques;Cells;Complex;design;Disease;Distal;enzyme activity;Enzymes;Event;Goals;Health;Human;In Vitro;inhibitor;insulin secretion;Knowledge;Light;lipid metabolism;Methods;Molecular;Molecular Conformation;molecular dynamics;N-terminal;Nature;Nerve Degeneration;Non-Insulin-Dependent Diabetes Mellitus;Pathway interactions;Phosphorylation;Phosphorylation Site;Piceatannol;Play;Post-Translational Protein Processing;Property;Proteins;Regulation;Research;Rest;Resveratrol;Role;Sir2-like Deacetylases;SIRT1 gene;Sirtuins;small molecule;Structure;targeted treatment;Therapeutic;therapeutic target;tumor;Work

PROJECT_TITLE: Elucidating the Mechanism for Allosteric Regulation of SIRT1 through the N-terminal Region


ORG_CITY: GALVESTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Project Narrative National Biocontainment Laboratories Operational Support ensures the availability of maximum containment laboratories for research that will develop the next generation of therapeutics, diagnostics and vaccines for infectious diseases that can pose a public health risk. It also ensures that high containment labs are available in the event of a public health or bioterrorism emergency. This support is essential due to the high cost of building and maintaining laboratories that protect researchers, ensure the biosecurity of dangerous pathogens, and safeguard the communities where these laboratories are located.

PI_NAMEs: OLINGER, GENE GARRARD (contact)

PROGRAM_OFFICER_NAME: DIAZ SAN SEGUNDO, FAYNA C

PROJECT_TERMS: Address;Aerosols;animal care;animal rule;Applied Research;Arboviruses;Arthropod Vectors;Basic Science;biocontainment facility;biodefense;biosecurity;Biotechnology;Bioterrorism;career;Caring;Clinical Trials;Collection;Communicable Diseases;Communities;Containment;cost;Dangerousness;Development;Diagnostic;disease transmission;Education;Emergency Situation;Emerging Communicable Diseases;emerging virus;Ensure;Environment;Equipment;Event;experience;Faculty;Funding;global health;Goals;Guidelines;Human;imaging capabilities;Infrastructure;instrument;interest;International;Laboratories;Laboratory Animals;Laboratory Research;Licensure;Maintenance;Medical;medical countermeasure;Mentors;Modernization;Mus;National Institute of Allergy and Infectious Disease;next generation;nonhuman primate;novel;novel therapeutics;operation;pathogen;Policies;Preventive;product development;programs;Public Health;public health emergency;Qualifying;Quality Control;Reagent;Records;recruit;Regulation;Reproducibility;Research;research facility;Research Infrastructure;Research Personnel;Resolution;Resources;Risk;Scientist;Secure;skills;Students;Texas;therapeutic development;tool;Training;United States;United States Food and Drug Administration;United States National Institutes of Health;United States Public Health Service;Universities;Vaccines;Validation;Virus;Visualization;Work;Zoonoses

PROJECT_TITLE: Limited Competition: National Biocontainment Laboratories (NBLs) Operations Support (UC7 Clinical Trial Not Allowed)


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: KANSAS CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

ORG_STATE: MO

PHR: Project Narrative (3 sentences) Voltage-gated sodium channels are important membrane proteins regulating the excitability of many cells, tissues. Based on available atomic structures, my project will uncover the dynamic behaviors of model NavAb and human cardiac Nav1.5 channels in membrane environments with single molecule fluorescence imaging in combination with unnatural amino acid incorporation techniques. Together with functional characterizations, the proposed studies will elucidate the fundamental mechanisms underlying ion permeation, channel gating, and drug modulation.

PI_NAMEs: WANG, SHIZHEN  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Action Potentials;Address;Anti-Arrhythmia Agents;Anticonvulsants;Arrhythmia;Behavior;Binding;Biological Assay;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cations;Cell membrane;Cells;Charge;Chemistry;Complex;conformational conversion;Coupling;crosslink;Cryoelectron Microscopy;Cysteine;Data;drug modification;Drug Modulation;Drug Regulations;electrical potential;Electrophysiology (science);Environment;Exhibits;Flecainide;flexibility;fluorescence imaging;fluorophore;functional status;Goals;Helix-Turn-Helix Motifs;Human;insight;Integral Membrane Protein;Ion Channel Gating;Ions;Label;Lidocaine;Life;Liposomes;Maleimides;Membrane;Membrane Proteins;Mental disorders;method development;Methodology;Methods;Modeling;Molecular;Molecular Conformation;Molecular Target;Nervous System Disorder;next generation;novel;patch clamp;Pharmaceutical Preparations;pharmacologic;Property;Protons;Regulation;Resolution;Rest;Role;sensor;single molecule;single-molecule FRET;Sodium;Sodium Channel;Solid;Specificity;Structure;Techniques;Time;Tissues;unnatural amino acids;Visualization;voltage

PROJECT_TITLE: Structural dynamics of voltage-gated ion channels and their implications for ion permeation and drug modulation

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Prevention

PI_NAMEs: LEDUC, JAMES W. (contact)

PROJECT_TERMS: Address;Aerosols;Applied Research;Arthropod Vectors;Attention;Awareness;Basic Science;biocontainment facility;biodefense;biosecurity;Bioterrorism;Clinical Trials;Collaborations;Communicable Diseases;Communication;Communities;Containment;Coordination and Collaboration;Dangerousness;Development;Diagnosis;Diagnostic;Discipline;disease transmission;Emergency Situation;Emerging Communicable Diseases;Ensure;Equipment;Faculty;Funding;Future;global health;Goals;imaging capabilities;improved;Laboratories;Laboratory Animals;laboratory experiment;Leadership;Licensure;Maintenance;Medical;medical countermeasure;Mission;Mus;National Institute of Allergy and Infectious Disease;next generation;nonhuman primate;operation;pathogen;Prevention;product development;public health emergency;Publications;Readiness;Reagent;Research;Research Design;research facility;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;response;Secure;Security;Services;Structure;success;Texas;therapeutic development;tool;Training;Universities;Vaccines;Validation;Visualization;Zoonoses

PROJECT_TITLE: Core A - Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: KSIAZEK, THOMAS GARY (contact)

PROJECT_TERMS: Address;Aerosols;Air;Animals;Applied Research;Arthropod Vectors;Autopsy;Basic Science;biocontainment facility;biodefense;Biological;Biological Models;Bioterrorism;Breathing;Certification;Characteristics;Chemicals;Clinical Trials;Communicable Diseases;Communities;Containment;cost effective;Cost utility;Dangerousness;Data Management Resources;Data Protection;Decontamination;Development;Diagnostic;disease transmission;Emergency Situation;Emerging Communicable Diseases;Energy consumption;Engineering;Ensure;Equipment;Equipment and Supplies;Equity;experimental study;Funding;global health;Goals;high efficiency particulate air filter;Human Resources;Hurricane;imaging capabilities;In Vitro;Information Systems;Information Technology;Infrastructure;instrumentation;Interdisciplinary Study;Laboratories;Laboratory Animals;Licensure;Liquid substance;Maintenance;Mechanics;Medical;medical countermeasure;Monitor;Mus;National Institute of Allergy and Infectious Disease;next generation;nonhuman primate;operation;Operations Research;pathogen;Preparation;Procedures;product development;programs;public health emergency;Reagent;repaired;Research;research facility;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Resource Sharing;Resources;Safety;Schedule;Secure;Security;service delivery;System;Testing;Texas;therapeutic development;tool;Training;Universities;Vaccines;Validation;Visualization;wasting;Weather;Zoonoses

PROJECT_TITLE: Core B - Facility Maintenance and Operation Core


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Despite the unprecedent success of T cell immunotherapies in treating some previously refractory cancers, terminal exhaustion of chronically stimulated T cells remains a major obstacle to achieving durable protective immune responses. We discovered a novel approach to synergize the efficacy of T cell immunotherapies by modulating microenvironmental signals that regulate T cell-intrinsic epigenetic programs. The goals of this grant are to identify the role of these upstream regulators of the epigenetic programs specific to terminally-exhausted T cells, and to re-route their epigenetic programming toward the functional state.

PI_NAMEs: GHONEIM, HAZEM E. (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Acceleration;Address;Adoptive Transfer;Agonist;antagonist;Back;Biological Models;Breast Adenocarcinoma;Cancer Patient;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Chromatin;chromatin remodeling;Chronic;chronic infection;Clinical;CRISPR/Cas technology;CTLA4 gene;cytotoxic;cytotoxic CD8 T cells;Data;DNA Methylation;DNMT3a;Effectiveness;Endowment;Enzymes;Epigenetic Process;epigenome;Equilibrium;exhaust;exhaustion;experimental study;Failure;Functional disorder;functional restoration;Genes;Genetic Transcription;Glioma;Goals;Grant;Human;immune checkpoint blockade;Immune response;Immunotherapy;In Vitro;in vitro Model;in vivo;in vivo Model;Infection;insight;Knowledge;Link;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Mediating;Melanoma;Memory;Methods;Modeling;Molecular Target;Morbidity - disease rate;mortality;Mus;Nature;novel;novel strategies;Pathway interactions;Patients;Pre-Clinical Model;prevent;progenitor;programmed cell death protein 1;programs;receptor;Refractory;refractory cancer;Rejuvenation;Reporting;Resistance;response;restraint;retroviral transduction;Role;Route;Signal Pathway;Signal Transduction;Specificity;stem;stemness;success;synergism;System;T cell differentiation;T-Lymphocyte;Technology;Testing;Therapeutic;tool;transcriptome;Transforming Growth Factor beta;Transgenic Organisms;Translating;tumor;Viral;Viral Cancer;Virus;Virus Diseases

PROJECT_TITLE: Enhancing the Effectiveness of Immunotherapies by T Cell Epigenetic Reprogramming

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


PROJECT_TERMS: Address;Aerosols;Applied Research;Arthropod Vectors;Basic Science;biocontainment facility;biodefense;Biological Products;biosecurity;Bioterrorism;Clinical Trials;Communicable Diseases;Communities;Community Outreach;Containment;Dangerousness;Development;Devices;Diagnostic;disease transmission;Emerging Communicable Diseases;Employee;Ensure;Environmental Health;Equipment;Funding;global health;Goals;Human Resources;imaging capabilities;Laboratories;Laboratory Animals;Law Enforcement;Laws;Licensure;Maintenance;Medical;medical countermeasure;member;Mus;National Institute of Allergy and Infectious Disease;next generation;nonhuman primate;Occupations;operation;pathogen;Police;Preventive;product development;programs;public health emergency;Reagent;Regulation;Research;research facility;Research Infrastructure;Research Personnel;Resources;Schedule;screening;Secure;Security;Services;Texas;therapeutic development;tool;Toxin;Training;Universities;Vaccines;Validation;Visualization;Work;Zoonoses

PROJECT_TITLE: Core C: Biosecurity Core


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Outcomes of this work will elucidate the complex signal sensing mechanisms of the RpoN-RpoS pathway, which will fill a major gap in our understanding of Bb host adaptation. These findings will not only allow us to gain insight into host adaptation of the Lyme disease pathogen, it will also form a basis for developing strategies to block the enzootic cycle of vector-borne bacterial pathogens.

PI_NAMEs: YANG, X. FRANK  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Antigens;Arthropod Vectors;Bacteria;Bacteria sigma factor KatF protein;bacterial genetics;Binding;Binding Proteins;Borrelia burgdorferi;Borrelia oxidative stress regulator;Complex;Defect;enhancer binding protein;enzootic;Escherichia coli;Feedback;Funding;Gatekeeping;Gene Expression;Genes;Genetic Screening;Genetic screening method;Genetic study;Genetic Transcription;genome-wide;genome-wide analysis;In Vitro;in vivo;Infection;insight;Ixodes;Knowledge;Libraries;Lyme Disease;Mammals;Messenger RNA;Mutagenesis;mutant;Nature;novel;Outcome;pathogen;pathogenic bacteria;Pathway interactions;posttranscriptional;Process;Production;promoter;Proteins;Public Health;Regulation;Regulatory Pathway;Regulon;RNA-Binding Proteins;Rodent;Role;Sigma Factor;Signal Transduction;Testing;tick feeding;Tick-Borne Diseases;Ticks;tool;Transcription Coactivator;Transcriptional Activation;transmission process;United States;vector tick;vector-borne;Virulence Factors;Work

PROJECT_TITLE: Regulatory Network of the Lyme Disease Pathogen

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


PI_NAMEs: NTIFORO, CORRIE  (contact)

PROJECT_TERMS: Address;Aerosols;Animals;Applied Research;Appropriateness Review;Arthropod Vectors;Basic Science;biocontainment facility;biodefense;Biological;Bioterrorism;Caring;Clinical;Clinical Management;Clinical Trials;Communicable Diseases;Consultations;Containment;Dangerousness;Development;Diagnostic;Disease;disease transmission;Ebola;Emergency response;Emerging Communicable Diseases;Employee Health;Ensure;Environmental Health;Event;Exposure to;Funding;global health;Goals;hands on instruction;Health;Healthcare;Human Resources;IACUC;imaging capabilities;Individual;Infection;Infectious Agent;Infectious Diseases Research;Institution;Laboratories;Laboratory Animals;laboratory experience;Laboratory Personnel;Leadership;Length;Licensure;Maintenance;Medical;Medical center;medical countermeasure;member;Mentorship;Mus;National Institute of Allergy and Infectious Disease;next generation;nonhuman primate;Occupational Health Services;operation;pathogen;Pathogenicity;Patients;Physician Executives;Police;Police officer;Principal Investigator;procedure safety;Procedures;product development;programs;Protective Devices;public health emergency;Reagent;Recombinant DNA;Regulation;Research;research facility;Research Infrastructure;Research Personnel;Resources;response;Risk;Safety;Secure;Services;Site;Techniques;Texas;therapeutic development;tool;Training;Training Programs;treatment center;Universities;Vaccines;Validation;Veterinarians;Visualization;Zoonoses

PROJECT_TITLE: Core D -Environmental Health and Biosafety Regulations and Requirements Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: NEW YORK

ORG_NAME: INTERNATIONAL AIDS VACCINE INITIATIVE

ORG_STATE: NY

PHR: Project Narrative A new tuberculosis (TB) vaccine is urgently needed to bring an end to the deadly TB epidemic, which, only second to COVID-19, kills more people than any other infectious disease in the world. The only effective strategy to meet the United Nations Sustainable Development Goals and the WHO End TB strategy is a TB vaccine to stop transmission (8, 9), which would be the single most cost-effective tool in ending the TB epidemic (5). The cutting-edge mRNA platform, recently proven as an effective vaccine technology against COVID- 19, combined with rationally selected Mtb antigens and IAVI’s strong track record for vaccine development, make this approach well-positioned to deliver a meaningful impact on public health.

PI_NAMEs: POSTLER, THOMAS SIEGMUND (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Adjuvant;Adolescent;Adult;Algorithms;Animal Model;Animals;Antigenic Diversity;Antigens;Cause of Death;Cavia;Cessation of life;Clinical;clinical development;Clinical Trials;Codon Nucleotides;Communicable Diseases;cost effective;COVID-19;COVID-19 pandemic;Data;Data Set;design;Development;Diabetes Mellitus;Disease;Dose;Drug resistance in tuberculosis;Epidemic;Evaluation;Generations;glycosylation;Goals;Head;HIV;Human;immunogenicity;immunological diversity;Incidence;Individual;Infectious Agent;innovation;Lead;lead candidate;Learning;Mammalian Cell;Messenger RNA;Modeling;Modification;Mus;mycobacterial;Mycobacterium tuberculosis antigens;non-Native;nonhuman primate;novel;novel strategies;novel vaccines;pandemic disease;Persons;Phase;phase 1 study;Phase I Clinical Trials;Positioning Attribute;pre-clinical;prevent;product development;programs;Proteins;Public Health;Recombinant Proteins;Regimen;Reporting;Research;research and development;RNA vaccine;Subunit Vaccines;Sustainable Development;Technology;Time;tool;transmission process;Tuberculosis;Tuberculosis Vaccines;United Nations;Vaccination;vaccine candidate;vaccine development;Vaccines;vector vaccine;Viral Vector

PROJECT_TITLE: Development of Novel mRNA Vaccines Against Mycobacterium tuberculosis


PI_NAMEs: BEASLEY, DAVID  (contact)

PROJECT_TERMS: Address;Aerosols;Animals;Applied Research;Arthropod Vectors;Basic Science;biocontainment facility;biodefense;Bioterrorism;Clinical Trials;Communicable Diseases;Communities;Containment;Dangerousness;Development;Diagnostic;disease transmission;Documentation;Emerging Communicable Diseases;Ensure;Evaluation Studies;evaluation/testing;Funding;Funding Agency;global health;Goals;high risk;imaging capabilities;improved;Laboratories;Laboratory Animals;laboratory facility;Licensure;Maintenance;Medical;medical countermeasure;Mus;National Institute of Allergy and Infectious Disease;next generation;nonhuman primate;operation;pathogen;product development;public health emergency;quality assurance;Reagent;Research;research facility;Research Infrastructure;Research Personnel;Resources;Secure;Standardization;System;Texas;therapeutic development;tool;Training and Education;Universities;Vaccines;Validation;Visualization;Zoonoses

PROJECT_TITLE: Core E - Regulatory Compliance Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Growing evidence demonstrates that secure attachment in childhood predicts children’s healthy social, biological, and behavioral functioning, whereas insecure attachment predicts behavior problems and physiological dysregulation; thus, efforts to foster secure attachment are crucial for promoting the healthy development of children and families. This proposal describes a randomized controlled trial (RCT) of an innovative intervention program that can be widely implemented designed to foster children’s secure attachment, promote healthy physiological regulation, and reduce the risk for behavior problems: The Circle of Security – Parenting intervention. To this end, we will conduct an RCT with 249 parent-child dyads enrolled in two diverse Early Head Start programs.

PI_NAMEs: CASSIDY, JUDE A (contact);WOODHOUSE, SUSAN SOLEDAD

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Adaptive Behaviors;Address;Adverse effects;Area;behavior prediction;Behavioral;Berlin;Biological;Buffers;caregiving;Child;Child Behavior;Child Development;Child Mental Health;Child Rearing;Childhood;Collaborations;Communities;depressive symptoms;design;Development;Distress;early life stress;Effectiveness of Interventions;efficacy testing;efficacy trial;Emotional;Emotions;Enrollment;Environment;Evaluation;experience;Exposure to;Family;follow-up;foster child;Fostering;Foundations;Goals;group intervention;Head Start Program;Health;high risk;hypothalamic-pituitary-adrenal axis;implementation efforts;Infrastructure;innovation;Intervention;intervention effect;intervention program;Learning;Light;Link;Low income;Maternal Behavior;Mediating;Mediation;Mental Depression;Meta-Analysis;National Institute of Child Health and Human Development;Neighborhoods;Outcome;Parent-Child Relations;parenting intervention;Parents;physical conditioning;Physiological;post intervention;prevent;Prevention;Prevention Protocols;Problem behavior;Protocols documentation;Psychopathology;psychosocial adjustment;Public Health;Randomized, Controlled Trials;Recovery;Regulation;Research;resilience;Resources;response;Risk;Risk Factors;Risk Reduction;Risk Reduction Behavior;Sampling;Secure;Security;service delivery;Services;social;Source;Stress;stressor;Temperament;Testing;theories;therapy design;Trauma;Treatment Efficacy;violence exposure;Work

PROJECT_TITLE: Prevention of Attachment Insecurity, Physiological Dysregulation, and Child Behavior Problems

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: DALLAS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: 8. Project Narrative Our nervous system controls such remarkable abilities as learning, speaking, and walking only because our neurons communicate in highly organized networks. The goal of this proposal is to characterize the molecular and biochemical mechanisms that enable neurons to find and connect with one another during development and maintain these proper connections through-out adulthood. Understanding how these connections are assembled, integrated, and maintained will suggest solutions to diminish the burden of mental illness, reveal fundamental mechanisms underlying thought, emotion, and behavior, identify therapeutic strategies for multiple brain diseases and disorders, and contribute to healthy recovery following neural trauma.

PI_NAMEs: TERMAN, JONATHAN R (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Actins;Adhesions;Adhesives;Adult;Animals;Applications Grants;Axon;axon growth;axon guidance;axon regeneration;Behavior;Biochemical;Biological;Biological Models;Brain;Brain Diseases;Cell Surface Receptors;Cells;chemical reaction;Communication;Complex;Cues;Cyclic Nucleotides;Cytoskeletal Filaments;Cytoskeleton;Development;Didelphidae;Disease;Drosophila genus;Elements;Embryo;Emotions;Enzymes;Event;extracellular;Family;fly;Forms Controls;Funding;Genetic;Goals;Growth;Growth Factor;healing;Human;imaging approach;innovation;Instruction;Integrins;Learning;Length;Lesion;Link;Location;Maintenance;Mammals;Marsupialia;Mediating;Mental disorders;Mental Health;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;Microfilaments;Microtubules;Modeling;Molecular;Monomeric GTP-Binding Proteins;morphogens;Morphology;NADP;Nature;Nervous System;Nervous System control;neural;neuronal cell body;neuronal growth;neuronal metabolism;Neurons;novel;Nutrient;Oxygen;Pathologic;Pathway interactions;plexin;Polymers;Process;programs;Protein Family;Protein Tyrosine Kinase;Protein-Serine-Threonine Kinases;Proteins;Psyche structure;receptor;Recovery;Research;Resolution;response;Scientist;Semaphorins;Shapes;Signal Pathway;Signal Transduction;spatiotemporal;Specific qualifier value;Spinal Cord;Students;substrate-attached material;Surface;Testing;Therapeutic;Trauma;Tubulin;Walking;Work

PROJECT_TITLE: Molecular mechanisms of axon guidance and neural connectivity

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: NICHOLS, JOAN ELIZABETH (contact)

PROJECT_TERMS: Address;Aerosols;Animal Model;Animals;Applied Research;Arthropod Vectors;Basic Science;biocontainment facility;biodefense;Bioterrorism;biothreat;Clinical Trials;Communicable Diseases;Containment;Dangerousness;Development;Diagnostic;Diagnostic tests;Disease;disease transmission;Emerging Communicable Diseases;Emerging infection;Environment;Faculty;Funding;global health;Goals;Human Resources;imaging capabilities;Institution;Investigation;Laboratories;Laboratory Animals;laboratory experience;Licensure;Maintenance;Medical;medical countermeasure;Modeling;Mus;National Institute of Allergy and Infectious Disease;next generation;nonhuman primate;operation;pathogen;Postdoctoral Fellow;pre-doctoral;product development;programs;Protocols documentation;public health emergency;Reagent;Research;Research Activity;research facility;Research Infrastructure;Research Personnel;Research Support;Resources;Secure;Services;Site;Texas;Therapeutic;therapeutic development;therapy development;tool;Training;Universities;vaccine evaluation;Vaccines;Validation;vector;Visualization;Zoonoses

PROJECT_TITLE: Core F -Integrated Support Services Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Although metabolic demand from neuronal function has been shown to regulate vascular development in the retina, a detailed mechanistic understanding of how neuronal activity influences angiogenesis and blood-retinal barrier maturation remains unknown. This project will explore how cholinergic and glutamatergic neuronal activities (separately or in combination) regulate retinal angiogenesis and blood-retinal barrier maturation using genetic, molecular and imaging approaches. The knowledge gathered from this project may be of critical importance to understand the pathophysiology of retinal diseases associated with neurodegeneration and develop novel therapeutic interventions for their treatment.

PI_NAMEs: AGALLIU, DRITAN  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Address;Affect;angiogenesis;Angiogenic Factor;aquaporin 4;Basement membrane;beta catenin;Blood Vessels;Blood-Retinal Barrier;Caveolae;Cell Death;Cell Proliferation;Cells;cholinergic;cholinergic neuron;Data;Defect;Development;Endothelial Cells;excitotoxicity;extracellular;Functional disorder;Genetic;genetic approach;GLAST Protein;Glutamate Receptor;glutamatergic signaling;Glutamates;Growth;imaging approach;Knowledge;Measures;Mediating;Membrane Proteins;Metabolic;Molecular;Mouse Strains;Muller's cell;Mus;Mutant Strains Mice;Nerve Degeneration;Neuroglia;Neurons;Neurotransmitters;neurovascular unit;notch protein;novel;novel therapeutic intervention;Pathway interactions;PECAM1 gene;Permeability;pharmacologic;Phase;Phenotype;Photoreceptors;postnatal;Process;Regulation;response;Retina;retinal angiogenesis;Retinal Diseases;Role;sensor;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Synapses;Synaptic Cleft;Testing;Tight Junctions;Tracer;Transcript;transcriptomics;Transducers;Transforming Growth Factor beta;uptake;Vascular Endothelial Growth Factors

PROJECT_TITLE: Neuronal Regulation of Vascular Development and Maturation in the Retina


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Comparative Effectiveness Research;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: ATHENS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative  This project will design and implement a user-friendly, versatile, and computationally efﬁcient R pack- age named TranStat for analyzing infectious disease transmission in close contact groups such as house- holds, classrooms, hospitals, and workplaces. It will provide power and sample size calculation for de- signing observational studies and intervention trials to evaluate control strategies in these settings, and it will include a detailed user manual, vignettes and example data sets. TranStat will allow public health ofﬁcials and researchers to design and analyze longitudinal studies of infectious disease transmission in close contact groups, generating critical insights to inform public health responses to infectious diseases.

PI_NAMEs: KENAH, EBEN ;YANG, YANG  (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: 2019-nCoV;Adult;Binomial Model;Child;Cholera;Chronic Disease;clinical trial enrollment;code development;Communicable Diseases;Computer software;Data;Data Set;design;Development;discrete time;disease transmission;disorder control;Documentation;Ebola;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;emerging pathogen;epidemic response;Epidemiologist;Epidemiology;epidemiology study;Event;Evolution;experience;flexibility;Generations;Heterogeneity;high risk;Hospitals;Household;Housing;improved;Individual;Infection;infection risk;Infectious Disease Epidemiology;Influenza;insight;intervention program;Intervention Trial;longitudinal analysis;Longitudinal Studies;Manuals;Modeling;Names;Norovirus;Observational Study;Outcome;Output;pathogen;Pathogenicity;Persons;Policy Maker;Population;Populations at Risk;Predisposition;Prophylactic treatment;Public Health;research and development;Research Methodology;Research Personnel;respiratory pathogen;response;Risk;Sample Size;simulation;Software Tools;Specific qualifier value;Statistical Methods;surveillance data;Time;tool;transmission process;Treatment Efficacy;Uncertainty;user-friendly;Vaccinated;Vaccination;vaccine efficacy;Vaccinee;Viral;Work;Workplace

PROJECT_TITLE: Developing TranStat: A user-friendly R package for the analysis of infectious disease transmission and control among close contacts


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases

ORG_CITY: ALBANY

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: Project Narrative Vascular malformations are a significant contributor to morbidity and are caused by mutations in PIK3CA. We have a unique animal model of PIK3CA-induced vascular malformation and will use this model in combination with other novel animal models and three-dimensional cell-based methods, to elucidate the molecular underpinnings of vascular malformations and effective strategies to treat this disease.

PI_NAMEs: PUMIGLIA, KEVIN M (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: 3-Dimensional;Affect;angiogenesis;Animal Model;Automobile Driving;Blood Vessels;Candidate Disease Gene;cell dimension;Cell model;Coupled;Development;Disease;Endothelial Cells;Etiology;Evaluation;Failure;FRAP1 gene;Gene Expression;Genes;genetic manipulation;Genetic Markers;Goals;Human;Immune system;In Situ Hybridization;In Vitro;in vitro Model;in vivo;in vivo Model;insight;insulin sensitivity;Intervention;malformation;Metabolic;Metabolic Pathway;Methods;Modeling;Molecular;Morbidity - disease rate;Morphogenesis;Mutation;novel;novel strategies;Patients;PIK3CA gene;PIK3CG gene;Proteins;response;Ribosomes;RNA;Role;Safety;Signal Transduction;Sirolimus;Testing;transcriptomics;Venous Malformation

PROJECT_TITLE: Molecular Mechanisms Regulating PIK3CA-induced Venous Malformations

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Hematology

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PI_NAMEs: NEMETH, ELIZABETA  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acceleration;Ally;Appointment;Area;Basic Science;Benign;Biological Sciences;Biomedical Research;Businesses;California;career;career development;Caring;Child;Clinical;Clinical Research;clinical training;cohort;Collaborations;collaborative environment;college;Communication;Communities;Development;Discipline;Doctor of Pharmacy;Doctor of Philosophy;Elderly;Engineering;Environment;Evaluation;experience;Feedback;Film;Foundations;Funding;Future;Goals;Grant;health care delivery;Health Sciences;Health Services;Hematological Disease;Hematology;Hospitals;improved;Infrastructure;innovation;Institution;Instruction;interest;Joints;Kidney;Knowledge;Laws;Learning;life span;Los Angeles;Medical;Medical center;medical schools;Medicine;member;Mentors;metropolitan;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Patient-Focused Outcomes;Physicians;Population;Postdoctoral Fellow;pre-doctoral;Privatization;programs;Public Health;Public Health Informatics;Public Hospitals;Publications;Recording of previous events;Research;Research Institute;Research Personnel;Research Project Grants;Research Training;Resources;Science;skills;Structure;Techniques;Training;Training Programs;translational medicine;Translations;Underrepresented Minority;Universities;urologic;Urology;Writing

PROJECT_TITLE: Training Core


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Narrative Recent advances in human genetics and genomics have identified a huge number of variations, some of which are responsible for genetically-inherited disorders, but for most, their impact on human health is completely unknown. In the context of the IGVF Consortium, we will functionally characterize the impact of variants for most Mendelian disease genes by comparing variant gene products with their reference gene product using an array of fundamental properties of proteins and phenotypic impacts, including protein stability (expression), subcellular localization, cell viability, cell morphology, and protein interactions. All data will be shared publicly with the IGVF “Genomic Variation and Function” Data and Administrative Coordinating Centers (DACCs) and “Predictive Modeling Projects” to increase the value of the results for the broad scientific community.

PI_NAMEs: VIDAL, MARC  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Affect;American;Benign;Biomedical Research;Catalogs;causal variant;Cell Survival;Cellular Morphology;Classification;ClinVar;Code;Collection;Communities;Complex;Data;Data Set;Databases;Development;Disease;DNA sequencing;Frustration;functional genomics;gene product;General Population;Genes;Genetic;Genetic Diseases;genetic information;genetic variant;genomic variation;Genotype;Goals;Health;Hereditary Disease;Human;Human Genetics;human genomics;human reference genome;Individual;insertion/deletion mutation;insight;Laboratories;Lead;Measures;Mediating;Mendelian disorder;Modeling;Molecular;molecular phenotype;National Human Genome Research Institute;novel;Online Mendelian Inheritance In Man;outcome prediction;Pathogenesis;Pathogenicity;Phenotype;phenotypic data;predictive modeling;Property;protein protein interaction;Proteins;Proteome;Resources;RNA Splicing;Source;Technology;Therapeutic Intervention;therapeutically effective;trait;Translating;Variant;variant of unknown significance;Work

PROJECT_TITLE: Molecular phenotyping of ~100,000 coding variants across Mendelian disease genes


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Narrative Mechanical forces play key regulatory roles in biology, with the emergent field of mechanobiology leading to new understandings of diseases such as bleeding disorders, cancer, and infectious diseases. However, discoveries have been impeded by limited access to instrumentation, challenging technical requirements, and constraints of current capabilities. We will solve these problems by developing powerful and accessible new nanoscale approaches that will democratize the fields of mechanobiology and single-molecule manipulation to accelerate the pace of discovery, and apply these approaches to answer key questions in the areas of hemostasis, immunology, and hearing.

PI_NAMEs: WONG, WESLEY PHILIP (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Acceleration;Address;Adhesions;Adhesives;Area;Behavior;Biochemical;Biological Assay;Biology;Blood Coagulation Disorders;Cells;Centrifugation;centrifuge force microscope;Communicable Diseases;Complex;deafness;Democracy;Development;Devices;Disease;DNA;driving force;Genomics;Growth;Hair Cells;Hearing;Hemostatic function;high throughput screening;Immune response;Immunology;insight;instrument;instrumentation;interest;Leukocytes;Life;Link;Malignant Neoplasms;Measurement;Measures;mechanical force;Mechanics;mechanotransduction;Methods;Microscope;Molecular;Movement;nanoscale;nanoswitch;Organism;Pathway interactions;Play;Process;Property;Protein Conformation;Proteins;Regulation;Research Personnel;response;Robotics;Role;screening;Shapes;single molecule;Spectrum Analysis;Structure;Technology;technology development;Tissues;tool;von Willebrand Factor

PROJECT_TITLE: Mechanical forces in nanoscale biology: From hemostasis to single-molecule centrifugation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE This is a phase I/II clinical trial to assess safety and efficacy of combination immunotherapy (Aim 1) of malignant pleural mesothelioma treated with autologous chimeric antigen receptor T cells genetically engineered to target mesothelin followed by pembrolizumab, an anti–PD-1 checkpoint blockade agent. We will analyze serially collected samples to assess adoptive (Aim 2) and endogenous immunity (Aim 3). Assessing the ability of checkpoint blockade to restore adoptive and endogenous T-cell function will advance our understanding of the immune response.

PI_NAMEs: ADUSUMILLI, PRASAD S. (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Adoptive Transfer;Adverse event;anti-PD-1;Antigen Targeting;Antigens;Autologous;Binding;Biopsy Specimen;CAR T cell therapy;CD19 gene;CD4 Positive T Lymphocytes;Cell Physiology;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;combat;Combination immunotherapy;Combined Modality Therapy;Cyclophosphamide;cytotoxic;Data;Disease;Distant Metastasis;Dose;engineered T cells;exhaustion;Face;FDA approved;Gene Modified;Guidelines;Human;immune checkpoint blockade;immune resistance;Immune response;Immunity;Immunotherapy;immunotherapy clinical trials;improved outcome;innovation;Insurance;Invaded;leukemia/lymphoma;Liquid substance;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Malignant Pleural Mesothelioma;Maximum Tolerated Dose;Mediating;mesothelin;National Comprehensive Cancer Network;Nature;Neoplasm Metastasis;neoplastic cell;Nivolumab;Normal tissue morphology;Pathway interactions;Patient-Focused Outcomes;Patients;pembrolizumab;peripheral blood;Phase;Phase I Clinical Trials;phase I trial;Phase I/II Clinical Trial;Pleural;Pleural cavity;Pleural Mesothelioma;primary endpoint;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Publishing;rare cancer;Reporting;Research Personnel;Resistance;response;Safety;safety assessment;Sampling;Series;Solid Neoplasm;standard of care;Stress;Surface Antigens;T cell therapy;T-Cell Activation;T-Lymphocyte;targeted delivery;targeted treatment;Therapeutic;Toxic effect;Translating;Treatment Cost;tumor;Tumor Antigens;tumor eradication;Tumor Promotion;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: A phase I/II combination immunotherapy clinical trial: mesothelin-targeted chimeric antigen receptor T cells and checkpoint blockade agent in pleural mesothelioma

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Rehabilitation;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Alcohol use disorder (AUD) is a serious public health problem, and alcohol-associated cognitive impairments contribute to the progression of AUD. This proposal will evaluate the combination of donepezil and cognitive remediation therapy (donepezil + CRT) as a treatment for AUD. This project has clinical potential to help patients suffering from AUD by improving their cognition and reducing alcohol consumption.

PI_NAMEs: BELL, MORRIS D.;YOON, GIHYUN  (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Adherence;Aftercare;Age;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol intervention;alcohol use disorder;Alcohols;Alzheimer's Disease;Back;Brain;cholinergic;Cholinesterase Inhibitors;Clinical;Cognition;Cognitive;cognitive benefits;cognitive enhancement;cognitive function;Cognitive remediation;cognitive training;Combined Modality Therapy;Data;Defect;Dendritic Spines;donepezil;Double-Blind Method;drinking;executive function;Heavy Drinking;Human;Impaired cognition;improved;indexing;Inflammation;Informal Social Control;Inpatients;Intervention;Learning;Measures;Memory;mild cognitive impairment;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;Neurocognition;Neurocognitive;Neurocognitive Deficit;neuron loss;Nootropic Agents;novel;open label;Outcome;Patients;Personal Satisfaction;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;Pilot Projects;Placebo Control;Placebos;psychosocial;Public Health;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recovery;Relapse;Reporting;Research;Short-Term Memory;Testing;Therapeutic Effect;Time;treatment adherence;treatment group;Treatment outcome;trial comparing;United States Food and Drug Administration

PROJECT_TITLE: The Combination of Donepezil and Cognitive Training for Treating Alcohol Use Disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Narrative We are collecting genetic data at an ever-increasing rate, driven largely by our success in understanding both rare and common diseases using today’s vast genomic datasets. Our computational methods are lagging far behind, however, and without fundamental improvements in how we store and process genomic data, we may never fully realize the potential health benefits of the data we are gathering. Our project applies the revolutionary “succinct tree sequence” data structure – which has yielded orders-of-magnitude gains in decades-old problems since its recent introduction – to produce further major gains in fundamental genomics algorithms, genome simulation, and inference from genomic data.

PI_NAMEs: RALPH, PETER LOCHHEAD (contact)

PROGRAM_OFFICER_NAME: WELLINGTON, CHRISTOPHER

PROJECT_TERMS: Address;Affect;Agriculture;algorithm development;Algorithms;Architecture;Area;Astronomy;Base Sequence;Collection;Communities;Complex;computer framework;Computer software;Computing Methodologies;cost;Culicidae;Data;Data Compression;data format;Data Set;data structure;deep learning;design;Development;Disease;Ecology;Ensure;Epidemiology;Etiology;Evolution;frontier;Genealogical Tree;Generations;Genetic;Genetic Processes;Genetic Recombination;Genetic Variation;Genome;genome-wide;genomic data;Genomics;Genotype;Goals;Haplotypes;Health Benefit;Historical Demography;human disease;Human Genetics;Human Genome;improved;Individual;interest;Internet;interoperability;Learning;Libraries;Maps;Mathematics;member;Methods;Modeling;Modernization;multicore processor;Mutation;next generation;novel strategies;open source;operation;Performance;Phase;Phenotype;Population;Population Genetics;Population Sizes;Positioning Attribute;Process;Production;Records;Research;Running;Sample Size;Sampling;scale up;sequence learning;simulation;Statistical Data Interpretation;statistics;Structure;success;supervised learning;Techniques;Testing;Time;Training;Trees;Validation;Variant;whole genome;Work

PROJECT_TITLE: Scaling up computational genomics with tree sequences

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Injectable therapies for blocking vascular endothelial growth factor (VEGF) have provided impressive initial benefits to most patients with neovascular age-related macular degeneration (nAMD), though some have a suboptimal response. Another drawback of anti-VEGF therapies is the short duration of action that requires that patients return to the clinic for injections every 1-2 months. Here we describe a novel topical drug delivery strategy for effective, patient-controlled delivery of inhibitors of hypoxia-inducible factor 1 (HIF-1) to provide broad suppression of vasoactive proteins in ocular diseases with neovascular sequelae.

PI_NAMEs: CAMPOCHIARO, PETER A;ENSIGN, LAURA  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: absorption;Acids;Angiopoietin-2;Animal Model;Animals;Award;biomaterial compatibility;Blindness;Blinking;Cellulose;Choroid;Choroidal Neovascularization;Chronic;Clinic;Cornea;Data;design;Development;Dose;Drug Delivery Systems;Drug Kinetics;Drug Stability;effective therapy;efficacy evaluation;efficacy study;Electroretinography;Engineering;Evaluation;Extravasation;Exudative age-related macular degeneration;Eye;Eye diseases;Eyedrops;Family suidae;Film;Formulation;Frequencies;Gel;Growth;Growth Factor;Histology;Human;hypoxia inducible factor 1;improved;improved outcome;inhibitor;inhibitor therapy;Injectable;Injections;innovation;International;Ions;Lasers;Legal patent;Life;Liquid substance;Maintenance;Maximum Tolerated Dose;Measurement;Measures;Modeling;Morphology;mouse model;neovascular;New Agents;novel;ocular surface;Organ;Oryctolagus cuniculus;Osmolalities;Outcome;Patients;Penetration;PGF gene;Pharmaceutical Preparations;Physiological;Pluronics;Polymers;Positioning Attribute;preclinical study;prevent;Property;Proteins;Rattus;receptor;Refractive Indices;residence;response;Retina;retinal damage;Retinal Neovascularization;Safety;safety assessment;Self Administration;Specialist;Stains;Structure;Supportive care;systemic toxicity;targeted agent;Technology;Testing;Therapeutic;Thinness;Time;Tissues;Topical application;Toxic effect;Translations;treatment strategy;Vascular Diseases;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factors;Viscosity;Visual Acuity;Water

PROJECT_TITLE: Topical delivery of HIF-1 inhibitors for retinal and choroidal vascular diseases

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: ANN ARBOR

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The way how various signaling pathways orchestrate cochlear development may be a key determinant to develop rational strategies in the treatment of hearing loss. We utilize mouse models to identify critical pathways and signaling molecules of the gene regulatory network that contribute to the development of the organ. The findings of this study will enhance our understanding of the developmental process and could lead to novel targets for the treatment of hearing loss.

PI_NAMEs: WALDHAUS, JOERG  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Agonist;aldehyde dehydrogenases;Alleles;analysis pipeline;APEX1 gene;Apical;ATAC-seq;Auditory;base;Birds;Candidate Disease Gene;candidate selection;Cell Size;cell type;Cells;Characteristics;Chromatin;Chromatin Remodeling Factor;citral;Classification;Cochlea;cochlear development;constitutive expression;Critical Pathways;Data;Data Set;Development;Developmental Process;Embryo;emx2 protein;Epigenetic Process;Erinaceidae;Exhibits;experimental study;Family member;Future;gain of function;Gene Expression;gene regulatory network;Genes;Genetic Transcription;GLI gene;Hair Cells;Hearing;hearing impairment;hearing loss treatment;HMGA2 gene;HMGA2 Protein;imprint;Individual;inhibitor;Inner Hair Cells;Laboratories;LacZ Genes;Learning;loss of function;Maps;Mediating;Mediator;Messenger RNA;MicroRNAs;Molecular;Monitor;morphogens;mouse model;Mus;MYO7A gene;Natural regeneration;novel;Nucleosomes;organ growth;Outcome;Oxidoreductase;Pathway Analysis;Pattern;Positioning Attribute;postnatal;progenitor;protein expression;reconstruction;Reporter;retinoic acid 4-hydroxylase;RNA;sensor;Shapes;SHH gene;Signal Pathway;Signal Transduction;Signaling Molecule;single cell ATAC-seq;single-cell RNA sequencing;smoothened signaling pathway;stem cells;Technology;Testing;Transcription Coactivator;transcription factor;Transcription Repressor;Translating;Tretinoin

PROJECT_TITLE: Patterning of the Cochlear Apex-to-Base Axis

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PI_NAMEs: LEE, HANNAH HOEUN (contact)

PROJECT_TITLE: Novel neural scaffold with temporal and spatial regulation of neurogenic factors

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Nanotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative:  Traumatic brain injury (TBI) can cause persistent cognitive-affective symptoms with few effective treatments. We will develop a multifunctional microsensor that can be implanted in the brain regions of interest, to monitor neuron activity and neurotransmitter levels, after TBI, in order to understand the biological origin of the symptoms and identify effective therapy.

PI_NAMEs: CUI, XINYAN TRACY (contact);WAGNER, AMY K

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acids;Acoustics;Acute;Affect;Affective;Affective Symptoms;Animals;associated symptom;Behavior;Behavior assessment;Behavioral;Behavioral Assay;Binding;Biochemical;Biological;Brain region;Carbon Nanotubes;Cell Death;Characteristics;Chemicals;Chronic;clinical application;Cognitive;cognitive function;common symptom;Corpus striatum structure;design;Detection;Devices;discrete time;Dopamine;dopamine transporter;effective therapy;electric impedance;Electrodes;Electrophysiology (science);Enzymes;excitotoxicity;flexibility;Frequencies;Functional disorder;global health;Glutamate Receptor;Glutamates;Goals;Health;Histologic;Histology;Immobilized Enzymes;Implant;implantable device;implantation;improved;improved outcome;in vivo;Individual;individualized medicine;Inflammatory;inflammatory milieu;Inflammatory Response;inhibitor;Injury;innovation;interest;Investigation;Measurement;Measures;Mechanics;Metabolic;microdevice;Microelectrodes;microsensor;Modality;Molecular;Monitor;Morphology;multimodality;nanoparticle;Nervous System Disorder;Nervous System Physiology;neural;Neurobehavioral Manifestations;neurochemistry;neuroinflammation;Neurons;neurotransmission;Neurotransmitters;new technology;nigrostriatal pathway;novel;object recognition;Output;Oxidases;Pathologic;Pathway interactions;Performance;personalized medicine;Phase;post-traumatic symptoms;postsynaptic;prepulse inhibition;protein expression;Rattus;Reaction;Research;response;response to injury;Ritalin;sensor;Serotonin;sex;Sex Differences;sham surgery;Signal Transduction;Site;Stimulant;Sucrose;Survivors;symptom treatment;Symptoms;TBI Patients;TBI treatment;Technology;technology platform;Testing;therapy development;Thinness;Time;Tissues;transmission process;Traumatic Brain Injury;Work

PROJECT_TITLE: Investigation of Cognitive and Affective Deficits Post TBI Using Multimodal Flexible Neural Probes

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Cardiovascular;Diabetes;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Despite the advances in cardiovascular disease prevention and therapeutics, the continued increase in metabolic disorders, such as diabetes and insulin resistance, associated with the obesity epidemic has driven up total mortality rates in the US for the first time in 10 years. To address this, our research is designed to understand how we can maintain an healthy storage of lipids in the adipose tissue to promote functional adipose tissue expansion and remodeling. Our findings will help identify novel strategies for treating metabolically driven cardiovascular heart disease and related complications.

PI_NAMEs: SORCI-THOMAS, MARY G (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Address;adipocyte differentiation;Adipocytes;Adipose tissue;Affect;Amino Acids;Automobile Driving;Binding Proteins;Blood Vessels;BMP2 gene;Bone Morphogenetic Proteins;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;Cardiovascular system;Cell Count;Cell Differentiation process;Cell Size;Cells;Cessation of life;Classification;cytokine;Data;Death Rate;design;Diabetes Mellitus;Endopeptidases;Energy Intake;Energy Metabolism;Enhancers;Equilibrium;Exhibits;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Family;Fatty acid glycerol esters;feeding;Fibrosis;flexibility;Gene Expression;Genes;Glucose;glucose metabolism;Glycoproteins;glycosylation;Hand;Health;Heart Diseases;Hemagglutinin;Heterogeneity;High Fat Diet;Human;Hyperplasia;Hypertrophy;In Vitro;in vivo;Inflammation;Inflammatory;insight;Insulin Resistance;Knock-out;Knockout Mice;Knowledge;Ligands;Link;lipid biosynthesis;lipid metabolism;Lipids;Lipoproteins;Literature;MADH2 gene;Mediation;member;Messenger RNA;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Mitochondria;Mucins;Mus;mutant;Names;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;Obesity Epidemic;overexpression;Pathway interactions;Pattern;Peptide Hydrolases;Phosphorylation;Plasma;Play;Population;precursor cell;Prevalence;Process;Procollagen;progenitor;Proliferating;Proteins;Research;response;Risk;Role;Series;Signal Pathway;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Specificity;Stress;Structure;Structure-Activity Relationship;Testing;Therapeutic;Threonine;Time;Tissue Expansion;Tissue imaging;Transforming Growth Factor beta;Triglycerides;Visceral;Weight

PROJECT_TITLE: Pcpe2 in Adipose Tissue Expansion and Lipoprotein Metabolism

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Caregiving Research;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Nutrition;Patient Safety;Pediatric;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Infants with orofacial clefts (‘cleft’) are at high risk of malnutrition in the first months of life, likely due to a host of factors involving the lack of timely care with the appropriate specialists, social determinants of health in the family, source of nutrition (e.g., breastmilk, formula), appropriate resources (e.g., bottles, breast pumps), caregiver factors, and infant health characteristics. This project will develop a predictive model using data from 18,000 US infants to identify infants at high-risk of developing malnutrition and determine the impact of undernutrition on adverse health outcomes including infection, surgical complications, and caregiver stress and reduced quality of life. Our findings will inform the development of tailored, high impact interventions to ensure timely growth and health of US infants with cleft.

PI_NAMEs: HEIKE, CARRIE LYN;MCKINNEY, CHRISTY MICHELLE (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: 5 year old;Address;adverse outcome;Age Months;Anatomy;Area;Birth;breast pump;care coordination;caregiver quality of life;caregiver stress;Caregivers;Caring;Characteristics;Child;Cleft Palate;Clinical;clinical care;clinical predictive model;cognitive development;Cohort Studies;comorbidity;Complement;craniofacial;Data;Data Science;Databases;Dental;Development;disability;Electronic Health Record;Ensure;experience;Face;Family;feeding;Fistula;Frequencies;Future;Goals;Growth;Health;hearing impairment;high risk;Human Milk;infancy;Infant;Infant Health;infant infection;infant outcome;Infection;Integration Host Factors;interest;Intervention;Investigation;Length;Length of Stay;Life;Malnutrition;Mastication;Methodology;Methods;National Institute of Dental and Craniofacial Research;Newborn Infant;nutrition;Operative Surgical Procedures;orofacial cleft;Otitis Media;Outcome;Pediatric Hospitals;peer;Phenotype;Population;predictive modeling;prevent;Prospective cohort;Prospective, cohort study;psychosocial;Quality of life;readmission rates;Records;Research;Research Design;Resources;Respiratory Tract Infections;Retrospective cohort;Retrospective cohort study;Risk Factors;Role;Sample Size;Sampling;Site;social health determinants;Source;Specialist;surgery outcome;Surgical complication;Sustainable Development;Translating;Underweight;United Nations;United States;United States National Institutes of Health;Vulnerable Populations;wasting;Weight;World Health Organization

PROJECT_TITLE: Leveraging Data for Infants with Cleft to Grow and Flourish: The BLOOM Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Eccrine sweat glands are water-secreting exocrine organs that arise from the skin during development and are indispensable components of the human thermoregulatory system. We have identified a novel population of cells in the dermal skin layer that is specified immediately next to each developing human and mouse eccrine gland and have shown that eccrine glands fail to develop when this dermal population is ablated. The proposed aims will define the mechanisms through which this eccrine-associated dermal population forms and directs eccrine gland formation, thereby generating a first-of-its kind recipe of extrinsic factors that can be leveraged in therapeutic efforts to repair and regenerate these essential human skin appendages.

PI_NAMEs: KAMBEROV, YANA G (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Ablation;Affect;Alleles;appendage;Biological;Cell Lineage;cell type;Cells;comparative;Consultations;Data;Data Analyses;density;Dermal;Dermis;Development;differential expression;Diphtheria Toxin;directed differentiation;Disease;eccrine;Eccrine Glands;Ectopic Expression;epidermal stem cell;Epidermis;experimental study;extracellular;Fibroblasts;Follistatin;Gene Expression;Genetic;gland development;Goals;Human;in vivo evaluation;Life;Light;Maintenance;Mediator;member;Molecular;Mus;mutant;Natural regeneration;novel;Organ;Outcome;Patients;Phenotype;Physiologic Thermoregulation;Population;Property;Recipe;repaired;Research;S100A4 gene;Skin;Skin injury;Specific qualifier value;Sweat Glands;Sweating;System;Technical Expertise;Testing;Therapeutic;Transcript;transcriptomics;Validation;Water

PROJECT_TITLE: Mechanisms underlying the formation and function of the sweat gland dermal niche

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Glenohumeral osteoarthritis is a leading cause of shoulder pain and disability, but a lack of investigation of glenohumeral osteoarthritis risk factors has resulted in insufficient insights to guide evidence-based prevention and treatment strategies. Our proposal aims to leverage multiple existing data resources to determine associations of occupational exposures with osteoarthritis-related shoulder arthroplasty risk, identify genetic variants associated with risk of osteoarthritis-related shoulder arthroplasty, and develop prediction models for osteoarthritis-related shoulder arthroplasty. An understanding of glenohumeral osteoarthritis risk factors is critically needed to inform design of prevention approaches, provide new insights into osteoarthritis etiology, and to improve patient counseling in the future.

PI_NAMEs: YANIK, ELIZABETH LEE (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: administrative database;Age;Aging;Area;arm;Behavioral;biobank;cohort;Computerized Medical Record;Counseling;Data;data resource;Degenerative polyarthritis;design;Diagnosis;disability;Disability prevention;Disabling;Etiology;Evaluation;evidence base;Future;GDF5 gene;General Population;Genetic;genetic variant;genome sequencing;genome wide association study;genome-wide;Health Care Costs;high risk;Hip Osteoarthritis;Hip region structure;hip replacement arthroplasty;Hospital Records;Hospitalization;improved;innovation;insight;Investigation;Joints;Knee Osteoarthritis;knee replacement arthroplasty;Knowledge;Lifting;Link;Literature;Measurement;Measures;Medical Records;Modeling;novel;Occupational;Occupational Exposure;Occupations;Operative Surgical Procedures;Participant;patient population;Patients;Persons;population based;precision medicine;predictive modeling;Prevention approach;Prevention strategy;Procedures;prospective;radiological imaging;Recording of previous events;Replacement Arthroplasty;Risk;Risk Factors;risk prediction;sex;Shoulder;Shoulder Pain;study population;treatment strategy;US State;Variant;Weight-Bearing state;whole genome;Work

PROJECT_TITLE: Risk Factors for End-Stage Glenohumeral Osteoarthritis

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE This project will combine computational modeling and neuroimaging methods to study social and cognitive computations performed by the posterior cerebellum. The F99 phase will examine how the posterior cerebellum uniquely contributes to monetary and social reward processing, improving our basic scientific understanding of the cerebellum's core algorithmic capabilities and revealing the cerebellum's potential range of neural computations. The K00 phase will explore the cerebellum's mechanistic role in autism spectrum disorder through a reinforcement learning framework, providing insight into how a disruption in these processes may cause the canonical social deficits observed in this disorder.

PI_NAMEs: POPAL, HAROON SKANDER (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Activities of Daily Living;Adult;Affective;Algorithms;Applications Grants;Articulation;autism spectrum disorder;Basal Ganglia;Behavior;behavior observation;Brain;Brain region;cerebellar lesion;Cerebellum;Cerebrum;Clinical;Cognitive;cognitive process;Computational algorithm;computational neuroscience;Computer Models;Data;Data Set;design;Disease;emotion regulation;Emotions;Equilibrium;executive function;Exhibits;experience;experimental study;Face;Fellowship;fetal;Foundations;Functional Magnetic Resonance Imaging;Goals;Human;imaging study;improved;Incidence;Individual;individuals with autism spectrum disorder;insight;Laboratory Research;Language;Learning;Lesion;Link;Literature;Machine Learning;Mental disorders;Mentorship;Methods;Modeling;Motor;motor deficit;Mus;Neonatal;neural;neuroimaging;Neurons;Participant;Pattern;peer;Performance;Persons;Phase;Play;Population;Postdoctoral Fellow;Process;Psychological reinforcement;Reporting;Research;Research Personnel;Research Project Grants;response;reward processing;Rewards;Role;Schizophrenia;Sensory;skills;social;Social Behavior;social cognition;social deficits;social engagement;social learning;social neuroscience;supervised learning;Testing;theories;Training;Work;young adult

PROJECT_TITLE: Pinpointing the Cerebellum's Contribution to Social Reward Processing


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The proposed research aims to develop our understanding of how stimulation of the dorsolateral prefrontal cortex (DLPFC) influences the amygdala by utilizing a unique combination of invasive and noninvasive stimulation and recording techniques in humans. The findings will contribute to the development of a novel circuit-based strategy for precisely identifying a reliable stimulation site within the DLPFC that can effectively target and modulate the amygdala. This strategy will facilitate the rational design and widespread adoption of amygdala-targeted noninvasive neuromodulatory therapies for psychiatric disorders.

PI_NAMEs: JIANG, JING  (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Adoption;Amygdaloid structure;Anxiety;Brain;clinical translation;connectome data;Creativeness;Data;Data Set;Development;Electric Stimulation;Electroencephalography;Ensure;Epilepsy;evidence base;Evoked Potentials;Excision;Functional disorder;Functional Magnetic Resonance Imaging;Human;improved;Individual;innovation;Knowledge;Location;Magnetic Resonance Imaging;Maps;Measures;medial temporal lobe;Mental Depression;Mental disorders;Methods;mood symptom;multimodality;neuroregulation;neurosurgery;noninvasive brain stimulation;novel;Operative Surgical Procedures;Participant;Pathway interactions;Patients;Physiologic pulse;Positioning Attribute;Prefrontal Cortex;Psychiatric therapeutic procedure;Publishing;rational design;Records;Refractory;Research;Resistance;response;Rest;Risk;Role;Sensory;Signal Transduction;Site;targeted treatment;Techniques;Testing;Therapeutic Intervention;tool;Transcranial magnetic stimulation;Translating;Work

PROJECT_TITLE: Mapping a Causal Prefrontal Pathway for Amygdala Modulation Utilizing Invasive and Noninvasive Brain Stimulation and Recording Methods in Humans

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Functional magnetic resonance imaging (fMRI) is widely used to study how the human brain interacts with the world and how regions of the brain function as networks. However, head movement during the experiment – even just a few millimeters – leads to errors in the results and often severely limits research in populations that are likely to move, such as young children. In this project, we will develop comprehensive motion correction software that can be used in existing MRI scanners around the world to rapidly measure and compensate for all the relevant effects caused by head movement to provide stable, high-quality data. Our aim is to enable accurate assessment of functional networks despite being acquired during head motion.

PI_NAMEs: FROST, STEPHEN ROBERT (contact)

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: Acceleration;Accounting;Address;Age;Area;Behavioral;Brain;Brain region;Cephalometry;Child;Childhood;Clinical;Compensation;Computer software;Data;Data Analyses;Echo-Planar Imaging;Environment;experimental study;Fatty acid glycerol esters;Functional Magnetic Resonance Imaging;Head;Head Movements;Human;Image;image reconstruction;improved;interest;Knowledge;Lead;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mental disorders;millimeter;Morphologic artifacts;Motion;Nervous System Disorder;neuroimaging;Noise;Optics;Outcome;Physiological;Population;Positioning Attribute;prospective;radio frequency;reconstruction;Research;Research Personnel;Rest;Running;Scanning;sex;Signal Transduction;Slice;Software Tools;temporal measurement;Time;tool;Update;Water;Work

PROJECT_TITLE: Comprehensive prospective correction of head motion in functional MRI

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ORG_DEPT: PHARMACOLOGY

PHR: Elucidating the cellular and molecular underpinnings of liver injury repair may yield improved cures for liver diseases, which remain a global and national health burden. Pittsburgh Liver Research Center was created to address this issue by providing a group of invested established and early stage investigators an opportunity to interact and collaborate as well as have access to the most advanced scientific core facilities. We believe that PLRC will have a major impact on treatment of liver disease patients by enabling innovative discoveries.

PI_NAMEs: MONGA, SATDARSHAN SINGH (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;Adult;Area;base;Basic Science;Biological Specimen Banks;Biology;Biomedical Research;career;Categories;cellular imaging;Childhood;Clinical;clinical care;clinical practice;Collaborations;collaborative environment;community building;Complex;Comprehension;Continuing Education;Core Facility;Discipline;Disease;Education;empowerment;Ensure;equity, diversity, and inclusion;expectation;Extramural Activities;Fortification;Fostering;Funding;Genomics;Goals;Health;Hepatic;Hepatobiliary;Human;improved;improved outcome;Incentives;Individual;Infrastructure;Injury;injury and repair;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;interest;Interest Group;Investments;Liver;Liver diseases;liver injury;Medical center;Medicine;member;Mentors;Mission;Molecular;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Pathology;Patients;Physicians;Population;Process;programs;Records;repaired;Research;Research Infrastructure;Research Personnel;Research Support;Resources;Science;Scientific Advances and Accomplishments;Scientist;Services;Stratification;synergism;Systems Biology;Tissue imaging;Translations;Universities;Vision

PROJECT_TITLE: Pittsburgh Liver Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (J4)]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

PROJECT_TERMS: Area;base;Biomedical Research;Budgets;Clinic;Clinical Investigator;Collaborations;Communication;Communities;community building;Continuing Education;design;Development;Digestive System Disorders;Disease;Effectiveness;empowerment;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;Event;Faculty;Feedback;Fostering;Funding;Grant;Growth;Health;Hepatobiliary;Infrastructure;Injury;innovation;Institution;Instruction;Interdisciplinary Study;interest;Interest Group;Investigation;Leadership;Liver;Liver diseases;Measures;Medical center;member;Mentors;Mission;Modernization;Molecular;National Institute of Diabetes and Digestive and Kidney Diseases;news;Periodicals;permissiveness;programs;Publications;recruit;Recurrence;repaired;Research;Research Personnel;Resources;Science;Services;Structure;success;Technology;Time;Translations;Universities;Update;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Digestive Diseases;Liver Disease

PI_NAMEs: STOLZ, DONNA BEER (contact)

PROJECT_TERMS: Address;Algorithmic Software;Antibodies;Biotinylation;Caliber;Categories;Cells;cellular imaging;Complement;Computer software;computerized data processing;Consultations;Core Facility;Data;design;Disease;DNA;Electron Microscopy;Elements;Equipment;Evolution;Experimental Designs;experimental study;Feedback;Fixatives;Floor;Fluorescence;Fluorescence Microscopy;Fluorescence Recovery After Photobleaching;Fluorescence Resonance Energy Transfer;Fluorescent Probes;Freeze Fracturing;Gold;Health;Image;Image Analysis;imaging facilities;imaging modality;imaging platform;Immunofluorescence Immunologic;Immunohistochemistry;In Situ Hybridization;Individual;innovation;Instruction;instrumentation;Label;Laboratories;Leadership;Lectin;Light;light microscopy;light transmission;Lighting;Lipids;Liver;Measurement;medical specialties;member;Membrane;Microscope;Microscopic;Microscopy;Mission;Monitor;Morphology;multiphoton imaging;Optics;organizational structure;Pathology;Periodicals;Platinum;Polarization Microscopy;Proteins;quality assurance;Quality Control;Quantitative Evaluations;quantitative imaging;ratiometric;Reagent;reconstruction;Research;Research Infrastructure;Research Personnel;Resources;Scanning;Scanning Electron Microscopy;Services;Stains;Structure;Techniques;Technology;tissue culture;Tissue imaging;tissue reconstruction;Tissues;Training;Transmission Electron Microscopy;ultra high resolution;Universities

PROJECT_TITLE: Advanced Cell Tissue and Imaging Center


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Liver Disease

PI_NAMEs: SINGHI, AATUR DILIP (contact)

PROJECT_TERMS: Administrative Supplement;Anatomy;Ancillary Study;Animals;Applications Grants;Award;base;Basic Science;Biochemical;Biochemistry;Bioinformatics;Biological Specimen Banks;biomedical informatics;Biomedical Research;Blood;Board Certification;Cancer Center;career;Cell Separation;cell type;Cells;Center Core Grants;Charge;cholangiocyte;Clinical;Clinical Data;clinical investigation;Clinical Protocols;Clinical Research;Clinical Trials;Collection;Computer software;Consultations;cost;cost effective;Data;data management;Development;Diagnostic;Diagnostic Services;digital imaging;Endothelial Cells;Evaluation;experience;experimental analysis;Experimental Animal Model;experimental study;Formalin;Freezing;Funding;Goals;Harvest;Hepatocyte;Histopathology;Human;Human Resources;Immunohistochemistry;Institutional Review Boards;Instruction;Investigation;Kupffer Cells;Leadership;Liver;Maintenance;Malignant neoplasm of liver;member;Metadata;Mission;neoplastic;Operative Surgical Procedures;organizational structure;Paraffin Embedding;Pathologic;Pathologist;Pathology;Peripheral Blood Mononuclear Cell;Peritoneal Fluid;Plasma;preservation;Process;programs;Provider;quality assurance;Quality Control;Research;Research Personnel;Resources;Rodent;Scanning;Scheme;Serum;Services;Source;Stains;stellate cell;Structure;Supervision;System;Time;Tissue Embedding;Tissue Microarray;Tissues;Training;Training and Education;Translational Research;University of Pittsburgh Cancer Institute;Urine;Work

PROJECT_TITLE: Clinical Biospecimen Repository and Processing Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Digestive Diseases;Genetics;Human Genome;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LUO, JIANHUA  (contact)

PROJECT_TERMS: Affect;Algorithms;base;Bioinformatics;Biological;Biological Specimen Banks;Cells;Chromosomes;Clinical;clinical center;Clinical Data;Collaborations;Collection;commercialization;Complex;Computational Biology;computational suite;Computer Analysis;Computing Methodologies;Consultations;Copy Number Polymorphism;cost effective;Data;Data Analytics;Data Collection;data quality;Development;differential expression;Ensure;epigenome;experience;gene discovery;Generations;Genetic Polymorphism;Genomic Segment;Genomics;Genotype;Goals;Grouping;Health;Healthcare;high throughput technology;human disease;improved;Instruction;Knowledge;Lead;Leadership;Life;Liver;Machine Learning;machine learning model;member;Methods;Methylation;mid-career faculty;Mission;Molecular;multi-scale modeling;Multiomic Data;multiscale data;nanopore;Nucleotides;organizational structure;Pathology;Pathway Analysis;Patients;Phase;Phenotype;professor;programs;Protein Isoforms;Quality Control;Relationship-Building;Research;Research Design;Research Personnel;Research Project Grants;Services;single cell sequencing;Single Nucleotide Polymorphism;success;System;Systems Biology;Technology;Testing;tool;Training;transcriptomics;Translating;Translations

PROJECT_TITLE: Genomics and Systems Biology Core


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Liver Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: SOTO-GUTIERREZ, ALEJANDRO  (contact)

PROJECT_TERMS: Adult;Advisory Committees;Alcohols;Animals;Biliary;Biology;cell bank;Cell Communication;Cell Culture Techniques;Cell Separation;cell type;Cells;Childhood;Cirrhosis;Clinical;Communities;community center;CRISPR/Cas technology;Cryopreservation;Cues;data sharing;Detection;Disease;disease heterogeneity;Disease Progression;Disease susceptibility;end stage liver disease;Endothelial Cells;Epigenetic Process;Etiology;Evolution;Fibrosis;gene function;Genes;Genetic;Genetic Engineering;Genetic Polymorphism;Genotype;Goals;Hepatic Tissue;Hepatocyte;Hepatology;high risk;Histologic;Human;human disease;human induced pluripotent stem cells;innovation;Institution;Instruction;Kupffer Cells;Leadership;Liver;Liver diseases;Liver Dysfunction;liver transplantation;member;Metabolic;Metabolic Diseases;microphysiology system;Mission;Modeling;Modification;next generation;nonalcoholic steatohepatitis;novel;Organ;organizational structure;Organoids;Pathology;Patients;Phenotype;Physiological;Positioning Attribute;prevent;Primary carcinoma of the liver cells;programs;Research;Resources;risk variant;Services;Source;stellate cell;synthetic biology;System;Technology;Therapeutic;Tissues;tool;Training;Training and Education;Work

PROJECT_TITLE: Human Synthetic Liver Biology Core