NIH_SPENDING_CATS: Cancer;Clinical Research;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative This grant is designed to train neuro-oncologists – including adult and pediatric specialists in neurology, neurosurgery, radiation oncology, oncology, and radiology -- in the methods of research. The training program will expose the physician to coursework and hands-on experience in the laboratory. It is anticipated that after their training, graduates will continue to advance the field by developing clinical trials to test new treatments for patients with primary and metastatic tumors of the nervous system.

PI_NAMEs: PLOTKIN, SCOTT R (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Adult;Advertisements;Advisory Committees;Award;Basic Science;Biological Sciences;Biometry;Cancer Center;Childhood;Clinical;Clinical Research;Clinical Sciences;clinical training;Clinical Trials;Dedications;didactic education;Discipline;experience;Faculty;Feedback;Funding;General Hospitals;Grant;improved;Individual;Institution;Interdisciplinary Study;interest;Investigation;Investigational Therapies;Laboratories;Leadership;Massachusetts;Medical Oncology;medical specialties;Mentors;Monitor;Nervous System Neoplasms;neuro-oncology;neurosurgery;Oncology;patient oriented;Physicians;Positioning Attribute;Postdoctoral Fellow;Productivity;programs;Public Health Schools;Publications;Qualifying;Radiation Oncology;recruit;Recruitment Activity;Research;Research Methodology;Research Personnel;Resources;Scientist;Source;Technology;Training;Training Programs;Translational Research

PROJECT_TITLE: Training Program in Nervous System Tumors

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: OD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Data Science;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Rapidly-growing volume of biomedical datasets around the world promises to enable unprecedented insights into human health and disease. However, increasing concerns for individual privacy severely limited the extent of data sharing in the field. This project draws upon cutting-edge tools from cryptography and information theory to develop effective privacy- preserving methods for collecting, sharing, and analyzing sensitive biomedical data to empower advances in genomics and medicine.

PI_NAMEs: CHO, HYUNGHOON  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Acceleration;Address;Adoption;analysis pipeline;Biological;Biology;biomedical data science;Biomedical Research;brain magnetic resonance imaging;Clinic;Clinical Data;Code;Collaborations;Communication;Communities;Complex;Complex Analysis;Computational Biology;computer framework;Computer software;Computing Methodologies;computing resources;cost;cryptography;Data;Data Analyses;Data Collection;Data Science;Data Set;data sharing;design;Disease;diverse data;Electronic Health Record;empowerment;Engineering;Enhancement Technology;Ensure;experience;experimental study;Foundations;genetic analysis;Genome;genome wide association study;genomic data;Genomic medicine;Genomics;Goals;Guidelines;Head;Health;Human;Human Genetics;Image;Individual;infancy;Information Theory;innovation;insight;Institution;Interdisciplinary Study;International;Knowledge;Letters;Machine Learning;Mainstreaming;Mathematics;Medical Genetics;Medical Imaging;Medicine;Mentorship;Methods;Modernization;Molecular;Nature;novel;Pattern;pharmacologic;Policies;Polynomial Models;Preservation Technique;Privacy;privacy preservation;privacy protection;Privatization;Production;Research;Research Personnel;Resources;Risk;Science;Secure;Security;software development;Software Tools;statistics;Structure;success;task analysis;Techniques;Technology;tool;transcriptome;transcriptomics;Translations;Vision;web server;Work

PROJECT_TITLE: Computational Methods for Enhancing Privacy in Biomedical Data Sharing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Dental, Oral, and Craniofacial Disease;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative The proximal mechanisms driving racial/ethnic and socioeconomic inequalities in infant health and their impact across the lifespan remain poorly understood. The proposed project evaluates the contribution of inequalities and injustices in public drinking water contaminant exposure to potential inequalities in in utero contaminant exposures and subsequent inequalities in adverse birth outcomes. Characterizing the contribution of public drinking water inequalities to racial/ethnic and socioeconomic health disparities can have major implications for public drinking water regulatory policy in the US.

PI_NAMEs: NIGRA, ANNE E (contact)

PROJECT_TERMS: adverse birth outcomes;American Indians;Arsenic;Automobile Driving;Award;Biological Markers;Birth;Birth Records;Birth Weight;California;career;career development;Case Study;Child Health;Cities;classism;cohort;Collaborations;Communities;County;Data;data repository;Databases;Development;Disinfection;Disparity;Dose;drinking water;effectiveness evaluation;Environmental Health;environmental justice;Epidemiologist;Epidemiology;epidemiology study;ethnic disparity;Ethnic Origin;Evidence based intervention;Exhibits;Exposure to;Funding;Gestational Age;Health;health disparity;Hispanic;Imprisonment;improved;in utero;Inequality;Infant;Infant Health;Infrastructure;innovation;Institution;Journals;Lead;life span;Link;Low Birth Weight Infant;Maps;Measures;Metal exposure;Metals;microbial;Modeling;Monitor;Multiple Birth Offspring;novel;Outcome;outcome disparities;Participant;Peer Review;Policies;Positioning Attribute;Pregnancy;Premature Birth;prenatal exposure;primary outcome;Productivity;professor;programs;public drinking;public health intervention;Public Health Schools;Publications;Race;racial disparity;racial diversity;racial health disparity;Radioisotopes;recruit;Reduce health disparities;Regulation;Research;Research Personnel;Rural;secondary outcome;Small for Gestational Age Infant;socioeconomic disparity;Socioeconomic Status;socioeconomics;Strategic Planning;Structural Racism;Subgroup;System;tenure track;United States;United States Environmental Protection Agency;United States National Institutes of Health;Universities;urinary;Volatilization;Water;Water Pollutants

PROJECT_TITLE: Public Drinking Water Contaminants and Infant Health: Advancing Environmental Justice


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE The proposed translational research will use real-time metabolic imaging (hyperpolarized MRI) to assess tumor response to genotoxic stress induced by cisplatin in head and neck squamous cell carcinoma (HSNCC). The work is relevant to public health because this approach will provide a basis for adaptive changes to maximize treatment effectiveness and personalize the management of not only HNSCC, but also other solid tumors. As genotoxic agents remain the mainstay treatment for most solid tumors, this will be a true first step towards a precision oncology approach that we have been seeking for nearly half a century.

PI_NAMEs: BANKSON, JAMES A;LAI, STEPHEN Y (contact);SANDULACHE, VLAD C

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Address;Affect;Algorithms;Animal Model;Biochemical;Biological Assay;Biology;Biopsy;Cancer Etiology;Carbon;cell injury;cell killing;Cessation of life;Characteristics;Chemicals;chemotherapeutic agent;chemotherapy;Cisplatin;clinical application;Clinical Trials;clinically relevant;Coenzymes;Data;Data Analyses;design;Development;DNA;DNA Damage;Dose;drug testing;effective therapy;Effectiveness;Evaluation;Exposure to;Failure;Feedback;first-in-human;Genotoxic Stress;Glycolysis;Goals;Grant;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Heterogeneity;Human;Image;imaging biomarker;imaging modality;imaging probe;In Vitro;in vivo;Individual;individual patient;innovation;inorganic phosphate;insight;interest;Knowledge;Lactate Dehydrogenase;Link;Magnetic Resonance Imaging;Measurable;Measurement;Measures;Metabolic;metabolic imaging;Metabolic Pathway;metabolic phenotype;metabolomics;minimally invasive;Mission;Modeling;Mus;Mutagens;neoplastic cell;Nicotinamide adenine dinucleotide;Non-Invasive Detection;non-invasive imaging;novel;oral HPV-positive head and neck cancers;oral lesion;oxidation;Oxidation-Reduction;patient derived xenograft model;Patient Recruitments;Patients;personalized management;Pre-Clinical Model;precision oncology;preclinical trial;predicting response;predictive modeling;prospective;Public Health;Publishing;Pyruvate;quantitative imaging;Radiation therapy;randomized trial;Reaction;Recycling;Regimen;Research;Resistance;Resistance development;Resolution;response;Selection Criteria;Sensitivity and Specificity;Series;Shunt Device;Solid Neoplasm;standard of care;success;targeted agent;Testing;Therapeutic;Time;Toxic effect;transcriptomics;Translational Research;Treatment Effectiveness;Treatment Failure;treatment optimization;Treatment Protocols;treatment response;tumor;Tumor Burden;tumor growth;tumor metabolism;Tumor Volume;United States;United States National Institutes of Health;Work;Xenograft procedure

PROJECT_TITLE: Leveraging Hyperpolarized MRI for Precision Oncology Approaches in Head and Neck Cancer

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative The proposed research is directed at establishing a novel strategy of analyzing the feature space data extracted from medial images by deep neural networks (DNNs). Successful completion of the project will enable us to analyze the feature data reliably and quantify the quality of the feature space at different layers of a DNN. The study also promises to provide high-performance DNNs for medical image analysis to substantially improve the AI-based diagnosis, prognosis, and treatment of different diseases.

PI_NAMEs: ISLAM, MD TAUHIDUL  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Adoption;Black Box;Classification;Clinical;Clinical Data;clinical translation;Communities;Complex;computerized data processing;Data;data exploration;Data Reporting;Data Set;data space;data visualization;deep learning;deep neural network;design;Development;Diagnosis;dimension reduction;Dimensions;Discriminant Analysis;Disease;empowerment;Goals;high dimensionality;Image;Image Analysis;improved;indexing;Label;Learning;Mathematics;Medial;Medical Imaging;Methods;Modeling;multidimensional data;network architecture;neural network architecture;Neural Network Simulation;novel;novel strategies;operation;Output;Performance;Play;practical application;Process;Prognosis;Public Domains;Research;Research Personnel;Role;Structure;success;Techniques;Technology;Testing;tool;Training;treatment planning;trustworthiness;unsupervised clustering;Visualization

PROJECT_TITLE: High-performance deep neural networks for medical image analysis

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative The expression level of SIRT1 is often reduced in triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer that is difficult to treat and metastasizes with high frequency. The proposed research strategy will investigate the effects of decreased SIRT1 activity and expression in breast cancer progression and the regulatory mechanism that decreases SIRT1 expression in TNBC. Understanding the important tumor suppressive role of SIRT1 will provide new therapeutic strategies for the treatment of TNBC.

PI_NAMEs: MULLMANN, JAMES  (contact)

PROJECT_TERMS: 3' Untranslated Regions;3-Dimensional;Aggressive behavior;aggressive breast cancer;angiogenesis;Antigens;Antisense Oligonucleotides;Binding;Binding Sites;Biological Assay;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;Breast Epithelial Cells;cancer type;Cell Line;Cell Survival;Cells;chromatin immunoprecipitation;Development;Disease;DNA Binding;Down-Regulation;Enzymes;exosome;experience;extracellular vesicles;Family;Frequencies;Generations;Genetic Transcription;Hormonal;Human;Hydrolase;in vivo;insight;Invaded;Link;Malignant Breast Neoplasm;Malignant Neoplasms;mammary tumor virus;Measures;Mediating;Messenger RNA;Metastatic Neoplasm to the Lung;MicroRNAs;Modality;Modeling;Modification;Molecular;Mouse Mammary Tumor Virus;mouse model;Mus;Mutate;Nature;Neoplasm Metastasis;Normal tissue morphology;novel;novel therapeutic intervention;Nuclear;Nucleic Acid Regulatory Sequences;Oncogenes;overexpression;Pathway interactions;Patients;pharmacologic;Phenotype;Play;polyoma middle tumor antigen;Polyoma Virus Middle T Staining Method;posttranscriptional;prevent;Production;Prognosis;promoter;protein expression;Proteins;Proton Pump;Regulation;Research;Role;Running;Secretory Vesicles;SIRT1 gene;Sirtuins;small hairpin RNA;Small RNA;System;Therapeutic;Time;Tissue-Specific Gene Expression;Training;Transcript;transcription factor;Transcriptional Regulation;transcriptome sequencing;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;vacuolar H+-ATPase;Work

PROJECT_TITLE: Elucidating the tumor suppressive effects of the sirtuin, SIRT1, in triple-negative breast cancer


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: cAMP, synthesized by adenylyl cyclase, is present in all cell types and is used by several hormones for their normal function. We have recently identified a role for CAP1-Rap1 complex as a new regulatory unit in this pathway and a combination of in vitro biochemistry and optogenetics approaches in cells are proposed to study the molecular organization of the cyclase-CAP1-Rap1 complex and its function in regulating cAMP dynamics. Their characterization should aid our deeper understanding of the GPCRs’ spatiotemporal organization and function and might provide novel avenues for therapeutic intervention.

PI_NAMEs: ALTSCHULER, DANIEL L (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;Adenylate Cyclase;Affect;Agonist;Binding;Biochemistry;Biological;Biological Assay;Cell membrane;cell type;Cells;Chemosensitization;Chimera organism;Chronic;chronic pain;Code;Complex;Cyclic AMP;Data;Dose;Down-Regulation;Event;experimental study;Family;FDA approved;Feedback;Fluorescence Resonance Energy Transfer;Forskolin;G-Protein-Coupled Receptors;Generations;Genetic Transcription;Goals;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Proteins;Guanosine Triphosphate;Hormones;In Vitro;Inflammation;insight;interdisciplinary approach;interest;Intervention;Isoproterenol;Laboratories;Mammalian Cell;Mediating;Membrane;Migraine;Modeling;Molecular;Monitor;mutant;Mutation;nanobodies;new therapeutic target;novel;Nuclear;optogenetics;overexpression;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phase;Physiological;Protein Isoforms;receptor;Regulation;response;Role;Second Messenger Systems;sensor;Signal Transduction;Source;spatiotemporal;Specificity;Structure;Testing;Therapeutic Intervention;Transfection

PROJECT_TITLE: Novel mechanisms in the control of cAMP dynamics

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Rare Diseases

ORG_CITY: NEWPORT BEACH

ORG_NAME: HOAG MEMORIAL HOSPITAL PRESBYTERIAN

PHR: Project Narrative Current methods of measuring disease burden in myeloma are suboptimal, which limits clinical care of patients with myeloma. Our recent phase I, first-in-human trial of CD38-targeted immunoPET with 89Zr-DFO- daratumumab successfully demonstrated sensitive imaging of myeloma beyond the abilities of current imaging modalities; this phase II trial would identify promising clinical applications of 89Zr-DFO-daratumumab immunoPET in patients with myeloma, including histologic proof of imaging findings. Successful imaging would be transformative for the detection of myeloma, monitoring response to therapy, and future design of novel radioimmunotherapies for patients with myeloma.

PI_NAMEs: LANDGREN, CARL OLA ;ULANER, GARY ALLAN (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Antibodies;Biopsy;blind;Blood Tests;Bone marrow biopsy;burden of illness;cancer imaging;Cells;Clinical;clinical application;clinical care;Clinical Trials;clinically significant;Combined Modality Therapy;design;Detection;Detection of Minimal Residual Disease;Disease;dosimetry;early phase trial;experience;first-in-human;fluorodeoxyglucose positron emission tomography;Funding Opportunities;Future;Goals;Histologic;Human;human imaging;Image;imaging agent;imaging modality;Immunoglobulins;ImmunoPET;individual patient;innovation;Investigation;Laboratories;Measurement;Measures;Membrane Proteins;Memorial Sloan-Kettering Cancer Center;Methods;Monitor;Monoclonal Antibodies;Multiple Myeloma;multiple myeloma M Protein;novel;Patient Care;Patient imaging;Patient Monitoring;Patients;PET/CT scan;Phase;Phase I Clinical Trials;phase I trial;Phase II Clinical Trials;phase II trial;Plasma Cell Neoplasm;Plasma Cells;Positron-Emission Tomography;preclinical imaging;predicting response;Prognosis;Prognostic Marker;Protein Secretion;Qualifying;Radiochemistry;Radioimmunotherapy;Radiolabeled;Research Personnel;Residual Neoplasm;Safety;Selection for Treatments;Serum;Site;Surface;targeted imaging;theranostics;Therapeutic Agents;Tracer;Translations;treatment response;tumor;Tumor Burden;United States;uptake;virtual;Visualization;Work

PROJECT_TITLE: CD38-TARGETED IMMUNOPET OF MYELOMA: PHASE 2 TRIAL OF CLINICAL APPLICATIONS

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

PHR: Project Narrative  It has long been thought that DNA virus infection produces double-stranded RNA (dsRNA) from symmetrical transcription that can activate the innate immune response. However, recent work from myself and others has highlighted that many DNA viruses do not produce detectable levels of dsRNA over the course of infection. The work proposed in this project improve our understanding of virus-host interactions by highlighting new locations and sensors of low levels of viral dsRNA, as well as explore how this phenomenon can be exploited for viral gene regulation.

PI_NAMEs: PRICE, ALEXANDER MATTHEW (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 3' Untranslated Regions;Adenovirus Infections;Adenoviruses;Advisory Committees;antagonist;Anti-sense RNA;Anti-viral Response;Antibodies;Apoptosis;Base Pairing;Binding;Binding Proteins;Bioinformatics;Biology;career;Cell Nucleus;Cells;Cellular Stress;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Coupled;Cytoplasm;Data;DNA;DNA biosynthesis;DNA Virus Infections;DNA Viruses;Double Stranded DNA Virus;Double-Stranded RNA;ds RNA-Binding Proteins;ds-DNA;dsRNA adenosine deaminase;endonuclease;Environment;Exhibits;experience;experimental study;Faculty;Fluorescent in Situ Hybridization;Fractionation;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Herpesviridae;Human Herpesvirus 4;Immune response;Immunoprecipitation;improved;In Situ Hybridization;Infection;inhibitor;Innate Immune Response;Innate Immune System;insight;Integration Host Factors;Interferons;K-Series Research Career Programs;Knowledge;Learning Skill;Ligase;Location;Mass Spectrum Analysis;Mediating;Mentors;Messenger RNA;Modeling;Modernization;Modification;Molecular;mutant;Mutate;next generation sequencing;novel;Nuclear;oligoadenylate;Outcome;Outcome Study;pathogen;Pathway interactions;Pattern;Pennsylvania;Phase;Play;Positioning Attribute;PRKR gene;Process;Production;Property;Protein Biosynthesis;protein expression;receptor;Regulation;Research;Research Personnel;Resolution;response;Ribonucleases;RNA;RNA Binding;RNA Processing;RNA Splicing;RNA Viruses;Role;Scientist;Seminal;sensor;Signal Transduction;Simplexvirus;skills;Structure;success;System;Techniques;Technology;Testing;tool;Training;Transcript;transcriptome;transcriptome sequencing;Universities;Viral;viral detection;Viral Genes;Viral Genome;Viral Proteins;Virus;Virus Diseases;virus host interaction;Virus Replication;Work

PROJECT_TITLE: dsRNA production and sensing during DNA virus infection

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Palliative Care

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Dementia is inevitably considered progressive and irreversible in nature and culminates into an advanced stage, during which all independence is lost. However, paradoxical episodes of unexpected cognitive lucidity (paradoxical lucidity [PL]) especially near the end of life have been reported anecdotally for years in patients with advanced dementia, and may indicate the possibility of a network-level return of cognitive function. This may provide novel insights into the underlying neurobiology and delineate future therapeutic possibilities, and therefore we aim to systematically study the phenomenology, characteristics, and electrocortical biomarkers of PL in dementia and create a measurement scale.

PI_NAMEs: PARNIA, SAM  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Adherence;advanced dementia;Adverse event;Biological;Biological Markers;Brain;Caregivers;Cerebral Ischemia;Cerebrum;Cessation of life;Characteristics;Cognitive;cognitive function;Conscious;Consent;cost;Data;Dementia;design;diaries;Elderly;Electroencephalography;end of life;Epidemiology;Event;Factor Analysis;Family;Focus Groups;Frequencies;Future;Heart Arrest;hospice environment;Impaired cognition;Incidence;insight;Intervention;Life Expectancy;Location;Measurement;Methods;Monitor;multidisciplinary;Nature;Near-Death Experience;Neurobiology;Neurologic;New York;novel;Nursing Homes;Nursing Services;Palliative Care;Patients;Persons;Phase;phenomenological models;Preparation;prevent;primary outcome;Prospective Studies;Prospective, cohort study;Questionnaires;Records;recruit;Reporting;Research;Resources;safety and feasibility;safety outcomes;secondary outcome;Services;Site;Study Subject;Surveys;Symptoms;Testing;theories;Therapeutic;Time;tool;Visiting Nurse

PROJECT_TITLE: Paradoxical lucidity in severe end stage dementia: a mixed methods prospective study


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Patient Safety;Physical Activity;Prevention;Rehabilitation;Urologic Diseases;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative  We propose an innovative randomized controlled trial of prescriptive early exercise following pelvic organ prolapse surgery to help reduce the time to full recovery without impacting pelvic floor outcomes. With this study, we hope to drive the needle forward on the perioperative care of women undergoing minimally invasive surgery. This has the potential to transform care for women with prolapse who will no longer be required to alter their lifestyle and the activities for which they are having surgery.

PI_NAMEs: KENTON, KIMBERLY SUE (contact)

PROGRAM_OFFICER_NAME: TEPEDE, ABISOLA KAFAYAT

PROJECT_TERMS: Absence of pain sensation;Acceleration;Accelerometer;Adherence;Adult;Anatomy;arm;Back;Bladder;career;Caring;Centers for Disease Control and Prevention (U.S.);clinical research site;Clinical Trials;Collaborations;Counseling;Data;deconditioning;design;Distress;Ensure;Environment;Equipment and supply inventories;Equity;Exercise;exercise intensity;Exercise Physiology;exercise program;exercise regimen;Exercise Tolerance;experience;Family;Frequencies;Future;Goals;Health;Hospitals;improved;Infrastructure;innovation;Lead;Life Style;Masks;Measures;Medicine;minimally invasive;Moderate Exercise;multidisciplinary;Muscle;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;Needles;Operative Surgical Procedures;opioid sparing;Outcome;Patient Compliance;Patient Outcomes Assessments;patient population;Patients;Pelvic Floor Disorders;Pelvic floor structure;pelvic organ prolapse;Pelvis;Perioperative;Perioperative Care;Positioning Attribute;Postoperative Period;postoperative recovery;prevent;Productivity;Protocols documentation;Ptosis;Questionnaires;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Recovery;recruit;Recurrence;Reporting;Research;Research Personnel;Resolution;Resources;response;restricted physical activity;Scientist;Speed;Surgeon;Symptoms;Time;Urinary Incontinence;Woman;women's outcomes

PROJECT_TITLE: Pelvic Floor Disorders Network Clinical Site


ADMINISTERING_IC: MH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Psychotic disorders such as schizophrenia are common illnesses with serious, negative effects on patients and families; fortunately, recent studies suggest that early coordinated treatment might help mitigate some of these adverse effects. There remain many questions, however, about the disease course and treatment options, including what treatments will work best for which patients. This Center will be dedicated to addressing these questions by bringing together leading clinicians and scientists, and conducting research aimed to provide guidance to patients, families, and clinicians in the future.

PI_NAMEs: HERNAN, MIGUEL ;HSU, JOHN ;ONGUR, DOST  (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Address;Adverse effects;Advocate;analytical method;Antipsychotic Agents;Benchmarking;Binding;care systems;Caring;Clinic;clinical care;Clinical Data;clinical predictors;Clinical Research;Clinical Trials;Cognitive remediation;Collaborations;Comparative Effectiveness Research;Complement;Coordinated Specialty Care;Country;Data;Data Collection;data harmonization;data platform;data registry;Data Science;Data Set;Data Sources;data standards;Dedications;design;Development;digital;Discipline;Disease;diverse data;early psychosis;Economics;Effectiveness;electronic health data;Electronic Health Record;Epidemiology;Equity;Evolution;Face;Faculty;Family;first episode psychosis;Funding;Future;Goals;Health Policy;Health system;Healthcare Systems;Heterogeneity;improved;Infrastructure;Injectable;innovation;Inpatients;interdisciplinary collaboration;International;Intervention;knowledge base;Laboratories;Learning;Machine Learning;Massachusetts;Mental Health;Methods;Modernization;multiple data types;National Institute of Mental Health;North America;Operations Research;outreach;Patient Care;patient engagement;Patients;peer;Pharmacotherapy;Pilot Projects;Policies;Policy Maker;Provider;Psychiatry;Psychotic Disorders;Publishing;randomized, clinical trials;Randomized, Controlled Trials;Registries;Research;Research Design;Research Methodology;Role;Schizophrenia;Science;Scientist;Site;Source;standard of care;Standardization;statistics;Strategic Planning;Sum;System;Techniques;Testing;Training;treatment effect;trial design;Work

PROJECT_TITLE: Laboratory for Early Psychosis Research (LEAP)


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Health Services;Mental Health;Mental Illness;Psychosis;Schizophrenia;Serious Mental Illness

PI_NAMEs: ONGUR, DOST  (contact)

PROJECT_TERMS: Administrator;Advocacy;Agreement;Area;Authorship;Boston;Budgets;catalyst;Clinic;Clinical;Clinical Data;Collaborations;Communication;Community Outreach;Comparative Effectiveness Research;Coordinated Specialty Care;Data;data access;Data Collection;data management;Data Science;Data Set;data standards;data submission;Dedications;design;Development;Discipline;early psychosis;Elements;Ensure;Epidemiology;Evaluation;Faculty;Family;first episode psychosis;Fostering;Funding;Goals;Health Policy;Health Services Research;Heterogeneity;Hospitals;Hybrids;Incubators;Industry;Institutional Review Boards;interdisciplinary collaboration;Intervention;Laboratories;laboratory experiment;Lead;Location;Maintenance;Manuscripts;Massachusetts;Medicine;meetings;Mental Health;Methods;Modernization;Monitor;multimodality;National Institute of Mental Health;Nature;Occupations;Patient-Focused Outcomes;Patients;Performance;Persons;Pilot Projects;Policies;Policy Maker;Process;programs;Progress Reports;Psychiatry;Psychology;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Research Project Grants;Resources;Rotation;Schedule;Science;Series;Services;Site;Social Work;statistics;Strategic Planning;Structure;Sum;symposium;synergism;Testing;tool;Training;training opportunity;Training Programs;training project;Training Support;treatment effect;Twitter;virtual;visiting scholar;web site;Work

PROJECT_TITLE: LEAP Administrative Core


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Psychosis;Schizophrenia;Serious Mental Illness

PI_NAMEs: HERNAN, MIGUEL  (contact)

PROJECT_TERMS: Address;analytical method;Area;Caring;Characteristics;Classification;Clinic;Clinical;Clinical Data;clinical database;Clinical Management;clinical predictors;Collaborations;Collection;Communities;Comparative Effectiveness Research;compare effectiveness;computerized tools;computing resources;Data;Data Analyses;Data Collection;data integration;data management;data platform;data repository;data resource;Data Security;Data Set;Data Sources;data submission;Databases;Decision Making;Development;Discipline;diverse data;early psychosis;effective intervention;Electronic Health Record;Empirical Research;Ensure;Epidemiology;first episode psychosis;Funding;Generations;Health Insurance;Health Policy;Health system;Healthcare;high dimensionality;improved;Incubators;Infrastructure;innovation;insurance claims;Knowledge;Laboratories;large datasets;Lead;Link;longitudinal dataset;Machine Learning;machine learning algorithm;Massachusetts;Medicine;Mental Health;Methodology;Methods;Modeling;National Institute of Mental Health;novel;Outcome;Patients;Population;Procedures;Prospective cohort;Psychiatry;Public Health Schools;randomized trial;Randomized, Controlled Trials;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;response;Secure;Services;socioeconomics;statistics;Techniques;Technology;theories;Time;Training;Translational Research;Work

PROJECT_TITLE: LEAP Methods Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: HATTIESBURG

ORG_NAME: UNIVERSITY OF SOUTHERN MISSISSIPPI

ORG_STATE: MS

PHR: PROJECT NARRATIVE Oocyte meiosis is fundamental for successful embryo development. Errors in meiosis are associated with miscarriage and female infertility or subfertility. Using state-of-the-art experimental manipulation, this research will investigate the mechanisms of how oocytes control meiosis.

PI_NAMEs: CAMLIN, NICOLE JACQUELINE (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Acute;Antibodies;Auxins;Catalytic Domain;Cell Cycle;Communities;Complex;Data;Development;Disease;Embryonic Development;enzyme activity;experimental study;Exposure to;Failure;Family suidae;female fertility;Female infertility;Fertilization in Vitro;genetic approach;Global Change;Health;Heart Diseases;Holoenzymes;human model;Immunofluorescence Immunologic;Immunoprecipitation;Impairment;in vivo;Infertility;inhibitor;Injections;insight;interest;knockout gene;Lead;Light;live cell imaging;Mammalian Cell;Maps;Mediating;Meiosis;Methods;Mitosis;Mitotic M Phase;Molecular;mouse model;Mus;novel;novel strategies;Oocytes;optogenetics;Outcome;overexpression;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;protein degradation;Protein Dephosphorylation;Protein phosphatase;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Regulation;Reporting;Research;reverse genetics;RNA Interference;Role;small molecule;small molecule inhibitor;Somatic Cell;Spontaneous abortion;subfertility;Substrate Specificity;System;tool;Validation;Woman;Work;Yeasts

PROJECT_TITLE: Novel approaches for the discovery of dephosphorylation control in oocyte meiosis


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Mental Health;Mental Illness;Psychosis;Schizophrenia;Serious Mental Illness

PROJECT_TERMS: Adherence;Appointment;arm;blind;Blinded;care delivery;care outcomes;care systems;Caring;Case Management;Clinic;Clinical;Clinical Trials;Cognitive remediation;Collaborations;Complement;Coordinated Specialty Care;Data;Data Collection;data registry;Dedications;design;digital;Drops;Early Intervention;early psychosis;Education;Effectiveness;Electronic Health Record;experience;Face;falls;Family;Feedback;first episode psychosis;follow-up;Funding;Future;improved;improved outcome;Individual;Inpatients;Intervention;intervention program;Laboratories;Laboratory Research;Lead;Massachusetts;Mental Health;Methods;Modeling;National Institute of Mental Health;Outcome;outreach;patient engagement;patient retention;patient subsets;Patient-Focused Outcomes;Patients;peer;personalized intervention;Pharmaceutical Preparations;Policy Maker;primary outcome;Process;Provider;Psychotherapy;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Registries;remote health care;Research;Sampling;scale up;Scheme;secondary analysis;Services;Social Workers;Standard Model;Strategic Planning;Sum;Supported Employment;System;Testing;Time;Training;treatment arm;treatment as usual;United States Substance Abuse and Mental Health Services Administration;virtual;Visit;web site

PROJECT_TITLE: Randomized controlled trial of enhanced coordinated specialty care (CSC 2.0)


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Regenerative Medicine;Wound Healing and Care

ORG_CITY: BRIGHTON

ORG_NAME: GEL4MED, INC.

PHR: Project Narrative Deep tissue and tunneling diabetic foot ulcers (DTU-DFUs) are extremely difficult to treat with current wound care products, often becoming infected and putting patients at risk of lower limb amputation and death. To address this unmet clinical need, Gel4Med has designed G4Derm, a sterile, biosynthetic flowable matrix that uniquely combines tissue regeneration with microbial management. G4Derm has demonstrated efficacy and safety in preclinical studies and herein Gel4Med proposes a first-in-human clinical study to test the efficacy, safety, and feasibility of G4Derm in patients with DTU-DFUs; this study marks a significant advancement in the commercialization of G4Derm and has the potential to change clinical practice in the management of complex wounds.

PI_NAMEs: MEHTA, MANAV  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Address;Adoption;Affect;Aftercare;Amputation;Animals;antimicrobial;Bacteria;Biodegradation;Biological;biomaterial compatibility;bone;Cell-Matrix Junction;Cessation of life;Characteristics;chronic wound;clinic ready;Clinical;clinical efficacy;clinical practice;Clinical Research;clinical research site;clinical trial readiness;Clinical Trials;clinically relevant;commercialization;Complex;Consumption;cost;Cyclic GMP;Data;Data Analyses;Data Collection;Death Rate;Dermal;design;diabetic;Diabetic Foot Ulcer;diabetic patient;early onset;Economic Burden;Effectiveness;efficacy testing;Elements;Endotoxins;Environment;Evaluation;experience;fabrication;Face;Failure;first-in-human;follow-up;Funding;fungus;Gel;Goals;Granulation Tissue;Growth;healing;Healthcare Systems;Human;Hydration status;Hydrogels;Infection;infection risk;Institutional Review Boards;Intervention;Legal patent;Life;limb amputation;Lower Extremity;Mammalian Cell;manufacture;Medical;Membrane;Methodology;microbial;Microbial Biofilms;Microbiology;Morbidity - disease rate;multi-drug resistant pathogen;nanofiber;novel;Osteomyelitis;Outcome;Patients;Peptide Hydrolases;Peptides;Performance;performance tests;Phase;point of care;porcine model;Positioning Attribute;pre-clinical;preclinical safety;preclinical study;Preclinical Testing;Predisposition;Preparation;Price;Privatization;Process;Production;Property;Quality of life;randomized, clinical trials;Recurrence;Refractory;research and development;research clinical testing;Resistance;restoration;Risk;Risk Assessment;Running;Safety;scaffold;Secure;self assembly;Site;skin barrier;Skin Substitutes;socioeconomics;statistics;Sterility;Sterilization;study population;Surface;Syringes;Tendon structure;Testing;Thick;Time;Tissue Banks;tissue regeneration;tissue repair;Tissues;Treatment Cost;treatment duration;Ulcer;United States National Institutes of Health;Validation;Work;wound;wound care;wound closure;wound healing

PROJECT_TITLE: Antimicrobial dermal matrices to promote infection free wound closure in DTU-DFUs.


ORG_CITY: ATLANTA

ORG_DEPT: UROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Prostate Cancer is a leading cause of cancer-related death in American men with lethality due largely to castration-resistant prostate cancer (CRPC). This study will identify HOXB13 as a novel and important regulator of lipogenesis in PCa and elucidate how HOXB13 loss in CRPC promotes lipid accumulation and tumor metastasis. We will evaluate the efficacy of FASN inhibitors in targeting HOXB13 loss-induced effects and provide the foundation for the potential clinical use of FASN inhibitors in HOXB13-low CRPC patients.

PI_NAMEs: YU, JINDAN  (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: Ablation;Acetylation;Adult;American;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;androgen sensitive;Androgens;Biological Assay;Cancer Etiology;cancer initiation;Cancer Patient;Catalytic Domain;Cell Cycle;Cell Proliferation;Cells;Cessation of life;Chromatin;Clinical;Clinical Trials;cofactor;Complex;Data;Development;Diagnosis;Down-Regulation;early onset;efficacy evaluation;efficacy testing;enzalutamide;Enzymes;Epigenetic Process;Epithelium;Excision;Familial prostate cancer;Fatty-acid synthase;Foundations;Gene Expression;gene repression;Genes;Genetic Transcription;genomic locus;Germ-Line Mutation;Growth;HDAC3 gene;Histone Acetylation;Histone Deacetylase;Histone Deacetylation;Histones;homeodomain;Human;In Vitro;in vivo;inhibitor;Invaded;lipid biosynthesis;lipid metabolism;Lipids;Lysine;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Mediator;men;Metastasis Induction;Metastatic Prostate Cancer;Molecular;mutant;Mutation;NCOR1 gene;Neoplasm Metastasis;novel;Operative Surgical Procedures;Pathway interactions;patient derived xenograft model;Pharmaceutical Preparations;Play;programs;Prostate;prostate cancer cell;prostate cancer cell line;prostate cancer model;prostate cancer progression;prostate carcinogenesis;Prostate-Specific Antigen;Prostatic Neoplasms;Proteins;Radiation therapy;recruit;Refractory;Reporting;Repression;Resistance development;resistance mechanism;Retinoids;Role;Signal Transduction;Solid Neoplasm;Specimen;standard care;standard of care;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic Intervention;Thyroid Hormone Receptor;Tissue Microarray;transcription factor;tumor;tumor growth;Up-Regulation;Variant;Xenograft Model

PROJECT_TITLE: Comprehensive Analyses of HOXB13-regulated Transcriptional programs critical for Prostate Cancer Progression

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Mental Health;Mental Illness;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

PROJECT_TERMS: 15 year old;Adherence;Adolescence;Adolescent;Adult;aged;Amisulpride;Antipsychotic Agents;Area;aripiprazole;Benchmarking;Calibration;Caring;Case Study;Clinic;Clinical;clinical practice;clinically relevant;Collaborations;comparative effectiveness;Complement;Coordinated Specialty Care;Data;Diagnosis;early psychosis;Effectiveness;effectiveness evaluation;first episode psychosis;follow-up;Generations;Haloperidol;Hospitalization;Individual;Injectable;International;Intervention;Laboratories;Left;Massachusetts;Medicine;Mental Health;Methodology;Methods;Observational Study;olanzapine;Oral;Outcome;Participant;Patients;Pharmaceutical Preparations;pharmacologic;Population;pragmatic randomized trial;prevent;Prospective cohort;Psychiatry;Psychopharmacology;quetiapine;randomized trial;randomized, clinical trials;Relapse;relapse risk;Research;Research Methodology;Risk;Risk Reduction;Risperidone;Sample Size;treatment as usual;treatment group;treatment strategy;Work;ziprasidone

PROJECT_TITLE: Comparative effectiveness of pharmacologic strategies to treat first episode psychosis


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Cardiovascular;Cerebrovascular;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Narrative Impairment of cerebral microcirculatory blood flow in critically ill patients has been implicated as a pivotal pathophysiologic event associated with cognitive impairment and secondary brain injury, especially in elderly patients. The proposed work will a) clarify the critical interplay between micro- and macro-circulatory perfusion during clinically relevant scenarios and inform development of resuscitation strategies that maintain and enhance microcirculatory perfusion, and b) determine the relationship between sublingual, retinal and cerebral microcirculatory dynamics and their utilization as surrogate biomarkers for bedside perfusion management and thereby minimize secondary brain injury.

PI_NAMEs: HOFFMANN, ULRIKE  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;aged;Biological Markers;Blood capillaries;Blood flow;Blood Pressure;Blood Vessels;Brain;Brain Injuries;brain tissue;Cardiovascular Physiology;cerebral hemodynamics;Cerebrum;Clinical;clinical implementation;Clinical Management;clinically relevant;Complex;cranium;Critical Illness;Data;density;Development;Disease Outcome;Elderly;Event;Failure;Family suidae;genetic manipulation;Goals;Hematocrit procedure;hemodynamics;Hemorrhage;Heterogeneity;Homeostasis;Human;Hypotension;Iatrogenesis;Imaging Techniques;Impaired cognition;Impairment;improved;indexing;insight;Lead;Learning;Measures;Microcirculation;Microcirculatory Bed;Modeling;mouse model;multimodality;Mus;non-invasive monitor;novel therapeutic intervention;older patient;Outcomes Research;Oxygen;Pathologic;Patients;Perfusion;Proxy;Quality of life;Recovery;Regulation;Research;restoration;Resuscitation;Retina;Role;Sepsis;Shock;Surrogate Markers;Techniques;Time;Tissues;tool;vasoconstriction;Vasoconstrictor Agents;Work

PROJECT_TITLE: Assessment of retinal and sublingual microcirculation as surrogate biomarkers for cerebral microcirculatory dynamics

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: This application studies the cellular origin, signaling mechanism, and physiological function of a potentially novel light sensing pathway in mammalian retina. Success of the proposal provides a complete understanding of all light sensing mechanism in the retina and sheds light onto etiology of human incomplete color blindness. Knowledge of the novel light sensing pathway may be further harnessed in the future to be a therapeutic modality to combat blinding human diseases.

PI_NAMEs: CHEN, CHING-KANG JASON (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Ablation;achromatopsia;Adult;alpha Subunit Transducin;Amacrine Cells;Animals;Automobile Driving;Birth;Cell Density;Cells;channel blockers;Chemical Synapse;clinically relevant;Collaborations;Color blindness;combat;Cone;Couples;dark rearing;Darkness;Defect;Development;Diltiazem;DNQX;Electrical Synapse;Etiology;Future;Genetic;GTP-Binding Proteins;Human;human disease;Image;inhibitor;innovation;Knockout Mice;Knowledge;Light;Light Cell;light effects;Mediating;melanopsin;Metabotropic Glutamate Receptors;Methodology;Modality;Morphology;Mus;Mutation;Names;neuron development;novel;outer plexiform layer;patch clamp;Pathway interactions;Patients;Periodicity;pharmacologic;Photophobia;Photoreceptors;Phototransduction;Physiological;postnatal;postnatal development;presynaptic;response;Retina;Retinal Cone;Retinal Ganglion Cells;retinal neuron;Retinal Pigments;retinal rods;Rod;Role;Signal Transduction;Signaling Molecule;sildenafil;starburst amacrine cell;Structure;success;Synapses;synaptogenesis;Testing;Therapeutic;Transducin;Vertebrate Photoreceptors;Vision;Work

PROJECT_TITLE: Transducin and melanopsin independent phototransduction in postnatal retinal development

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Hematology;Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric;Women's Health Research

ORG_DEPT: PSYCHIATRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative:  Building on findings from animal studies and on preliminary data, from our laboratory, in adolescents with depression and anxiety, this project will be the first to investigate the impact of iron deficiency on brain iron content, brain structural and functional development, and psychiatric symptom severity. This information is necessary to guide future preventive interventions during a period of rapid brain maturation.

PI_NAMEs: CALARGE, CHADI A. (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: 17 year old;Adolescence;Adolescent;Adult;age group;Anatomy;Anemia;Animals;Anisotropy;Anxiety;anxiety symptoms;Area;Basal Ganglia;Blood;Bone Marrow;Brain;brain iron;Cause of Death;Child;child depression;Childhood;Clinical;clinically significant;cofactor;Cognition;Cognitive deficits;cognitive process;Corpus striatum structure;Cross-Sectional Studies;Data;depressive symptoms;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Distress;emotion regulation;Enrollment;Enzymes;Erythrocytes;Etiology;Female;Female Adolescents;Female of child bearing age;Ferritin;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Growth;Guidelines;Hippocampus;human data;Impairment;Iron;iron deficiency;Laboratories;Link;Magnetic Resonance Imaging;male;Maps;Measures;Medical;Menstruation;Mental Depression;Metabolism;micronutrient deficiency;Mitochondria;morphometry;Motility;MRI Scans;myelination;neural circuit;neuron development;neuropsychiatry;Neurotransmitters;novel;Organ;Oxygen;Participant;Peripheral;Play;pre-clinical;Predisposition;Prevalence;preventive intervention;Production;Productivity;psychiatric symptom;Research;Rest;reward processing;Risk;Role;Sampling;Serum;Severities;Signal Transduction;Structure;suicidal risk;Symptoms;Techniques;Therapeutic Intervention;Tissues;trend;white matter;Work;Youth

PROJECT_TITLE: Iron Deficiency and Brain Development in Youth with Internalizing Disorders

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Nutrition;Obesity

PHR: Project Narrative Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease, with prevalence growing in parallel with the obesity epidemic. NAFLD has no approved pharmacotherapy, due to incomplete understanding of its molecular mediators, compounded by unpredictable progression to liver inflammation and fibrosis, major determinants of morbidity/mortality of this disease. In this application, we study mechanisms by which Jagged-Notch signaling contribute to pathogenesis of NAFLD-related liver injury.

PI_NAMEs: PAJVANI, UTPAL  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Ablation;Affect;Animals;attenuation;Binding;Binding Proteins;Biology;Biopsy;Cell Separation;Cells;Cholesterol;chronic liver disease;Cirrhosis;Coculture Techniques;Communication;Complement;Complement Activation;Complication;Critical Pathways;Data;Decision Making;Development;Diet;Disease;Doxycycline;Endocrine;Exposure to;Fibrosis;Fructose;gain of function;Gene Expression;Genetic;Genetic Transcription;Goals;Grant;Hepatic Stellate Cell;Hepatocyte;Human;Immune;In Vitro;Inflammation;inhibitor;Injury;Intervention;Ligands;liquid chromatography mass spectrometry;Liver;liver biopsy;liver development;Liver Fibrosis;liver inflammation;liver injury;liver transplantation;loss of function;LoxP-flanked allele;LTBP2 gene;Mediating;Mediator;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;notch protein;novel;Obese Mice;obese patients;Obesity;Obesity Epidemic;obesogenic;Palmitates;Pathogenesis;Pathology;Pathway interactions;Patients;pharmacologic;Pharmacotherapy;Phenotype;Population;post intervention;Prevalence;Profibrotic signal;randomized, clinical trials;Recombinants;Reporter;Repression;Reproducibility;response;Risk Factors;Role;Series;Severity of illness;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sorting;Steatohepatitis;Testing;Therapeutic;tool;transcriptome sequencing;Transforming Growth Factor beta;Translating;validation studies;Wild Type Mouse;Work

PROJECT_TITLE: Jagged-Notch signaling in NASH/fibrosis

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE An impaired hematopoietic differentiation process underlies bone marrow malignancies like leukemia, but we still lack the mechanistic understanding of the sequence of regulatory events that misleads the differentiation process. Understanding the chromatin dynamics of a failed (malignant) hematopoietic differentiation process, in comparison to a healthy process, can define the molecular basis of leukemia. This research proposal seeks to develop a suite of computational tools for the multimodal integration of epigenomic data and use the framework to mechanistically investigate the corrupted hematopoietic differentiation process through mouse models of leukemia.

PI_NAMEs: SRIVASTAVA, AVI  (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Address;Awareness;Bone Marrow;Cancer Biology;career;career development;Cell Differentiation process;Cell Fate Control;cell fate specification;Cell Physiology;Cell Surface Proteins;cell type;Cells;Chromatin;computational suite;computer framework;Computer Models;computerized tools;Computing Methodologies;Data;design;Development;Development Plans;Enhancers;Environment;Epigenetic Process;epigenome;epigenomics;Event;experimental study;Gene Expression;gene regulatory network;Genes;Genetic Transcription;Genome;Goals;Grouping;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic Neoplasms;histone methylation;histone methyltransferase;histone modification;Histones;Impairment;improved;in silico;Investigation;Learning;leukemia;Link;loss of function;Malignant - descriptor;Malignant Neoplasms;Maps;Measurement;Mentorship;Modality;Modeling;Molecular;mouse model;multidisciplinary;multimodality;Mus;New York;novel;novel anticancer drug;Occupations;Pattern;Peripheral Blood Mononuclear Cell;Pilot Projects;Play;Polycomb;Process;promoter;Regulatory Element;Repression;Research;Research Personnel;Research Project Summaries;Research Proposals;Role;Scientist;single cell proteins;single cell technology;Specificity;System;Technology;Training;Transferase;Variant

PROJECT_TITLE: Integrated analyses of the epigenome to understand the molecular basis of hematopoietic malignancies


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cardiovascular;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infectious Diseases;Precision Medicine;Prevention;Social Determinants of Health

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE The goal of this study is to identify the genetic factors contributing to dental and systemic disease relationships. We will use clinical, demographic, and genetic data available through the All of Us Program Research Program to identify specific dental-systemic disease associations and the genetic variation(s) most likely contributing to such associations. This study represents a major advance in the field and will provide critical information to develop a more comprehensive picture of the interconnectedness between oral and systemic health/disease.

PI_NAMEs: LETRA, ARIADNE M (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Address;All of Us Research Program;Animals;Biological;Birth;Cardiovascular Diseases;Chronic;Clinical;Clinical Data;Coronary Arteriosclerosis;Data;Data Set;Dental;Dental caries;dental infection;Dental Records;Diabetes Mellitus;Disease;disease phenotype;dysbiosis;environmental stressor;Epidemiology;epidemiology study;Future;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;genetic variant;Genetic Variation;genome-wide;genomic data;Genomics;Genotype;Goals;Health;health care availability;Hypertension;improved;Individual;Inflammatory;Integration Host Factors;Knowledge;Learning;Medical;Medical Records;Medicine;microbial;Modeling;National Institute of Dental and Craniofacial Research;novel;Oral;Oral health;Participant;Pathogenesis;Pathway interactions;Patients;Periapical Diseases;Periapical Periodontitis;Pharmaceutical Preparations;phenome;Phenotype;polygenic risk score;Population;Population Group;Population Heterogeneity;population stratification;Precipitating Factors;Predisposing Factor;Predisposition;programs;Research;Research Personnel;Risk;risk variant;sex;social health determinants;Statistical Methods;Surveys;Systemic disease;Testing;tool;Tooth Diseases;Variant

PROJECT_TITLE: Leveraging All of Us data to unravel the interconnectedness between dental and systemic disease


NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Immunotherapy

ORG_CITY: LITTLE ROCK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE This study investigates T cell proteome turnover dynamics and the role it plays in tumor infiltrating T cell persistence. Understanding how T cell protein turnover rates are optimized to balance energy-saving stability and dynamic flexibility will provide conceptual advances in our understanding of the immune response to cancer. The identified mechanisms which endow T cells with superior adaptability will be applied to models of cellular therapy and utilized in clinical immune monitoring.

PI_NAMEs: KOSS, BRIAN  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Academic Training;Acclimatization;adaptive immunity;Adoptive Cell Transfers;Agreement;anti-cancer research;Antigens;Appointment;Area;Arkansas;Award;Biochemistry;Biology;Biomedical Research;cancer immunotherapy;cancer infiltrating T cells;cancer therapy;career;CD28 gene;Cell model;cell preparation;Cell Therapy;Cells;Centers of Research Excellence;Clinical;Collaborations;Complex;Dedications;Endowment;energy balance;Engineering;Ensure;environmental change;exhaustion;experience;Faculty;Failure;fitness;flexibility;frontier;Funding;Grant;Health;Hematologic Neoplasms;Hematological Disease;Home;Immune;Immune response;Immunologic Monitoring;Infiltration;innovation;Institution;interest;Malignant Neoplasms;Measurement;Measures;Medical;Mentors;Mentorship;Molecular Biology;Monitor;multiple omics;National Institute of General Medical Sciences;Nature;novel;novel strategies;Patient Monitoring;Patients;Persons;Play;Population Heterogeneity;Positioning Attribute;Principal Investigator;Productivity;professor;programs;protein degradation;Protein Dynamics;Proteins;Proteome;Proteomics;Publications;receptor;Research;research facility;Research Personnel;response;Role;Rural;Science;Set protein;Signal Pathway;skills;Solid Neoplasm;Source;Stress;Students;success;T-Lymphocyte;Techniques;tenure track;therapy development;Training;transcriptome;transcriptomics;treatment research;tumor;tumor heterogeneity;tumor microenvironment;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: Discovering T cell proteome turnover dynamics to overcome the solid tumor microenvironment


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Data Science;Depression;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

PHR: PROJECT NARRATIVE The proposed two-phase study seeks to respond to the growing burden of caregivers’ of children (including parents and teachers) mental health problems and urgent preventive service needs in Sub-Saharan African (SSA) countries by testing an integrated and potentially cost-efficient digital health intervention approach—the mHealth Toolkit for Wellness & Empowering Lives of School Community (mWEL) in one SSA country, Uganda. The mWEL App/toolkit provides screening, tailored mental health literacy materials, and stress management strategies for teachers and parents, and decision support for additional services. We will study feasibility and effectiveness of the mWEL intervention in schools, as well as conduct big-data analytics to optimize mWEL decision functions.

PI_NAMEs: HUANG, KENG-YEN  (contact);NAKIGUDDE, JANET

PROGRAM_OFFICER_NAME: BEKALU, MESFIN AWOKE

PROJECT_TERMS: Address;adolescent mental health;Adult;African;Anxiety;Automated Clinical Decision Support;Behavior;Behavioral;Big Data;Big Data Methods;Caregiver Burden;Caregiver support;Caregivers;Child;Child Care;Child Mental Health;Child Rearing;Clinical;Collaborations;Communities;Community Health Aides;cost;cost effective;cost efficient;Country;Data;data access;design;digital;digital health;digital mental health;Education;Effectiveness;effectiveness evaluation;effectiveness testing;emotion regulation;empowerment;evidence base;Feasibility Studies;feasibility testing;Feedback;Goals;Health Educators;health knowledge;health literacy;Health Professional;Health system;health training;High Prevalence;improved;Intervention;Kenya;Knowledge;Location;Machine Learning;Mental Depression;Mental Health;Mental health promotion;Mental Health Services;mHealth;Mobile Health Application;Modality;Modeling;Parents;Pattern;peer;peer support;personalized care;Phase;Policies;Population;population health;Practice Management;Prevalence;prevent;Preventive;Preventive healthcare;preventive intervention;Preventive service;Primary Schools;Problem Solving;Public Health;Randomized, Controlled Trials;Recommendation;Regulation;Reporting;Research;Research Personnel;Resources;Risk;Risk Factors;school health;Schools;screening;self help;Self Perception;service gap;Services;skills;social health determinants;Source;Stress;Stress and Coping;stress management;stress reduction;stressor;System;teacher;Technology;Testing;Time;tool;Training;treatment response;Uganda;usability;user centered design;Well in self;Work;young adult

PROJECT_TITLE: Promoting Mental Health of Teachers and Caregivers using a Personalized mHealth Toolkit in Uganda


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The overall objective of this proposal is to train and support underrepresented minority high school students (Black, Latinx, Indigenous, low-income, and future first-generation college students) to be co-researchers in a community-based participatory research program focused on adolescent health. At least 350 minority high school students will collaborate with and be mentored by our faculty team over the duration of the program, increasing drivers of persistence in science. This program will ultimately have a significant and widespread impact on pervasive disparities in the research workforce.

PI_NAMEs: DEJONCKHEERE, MELISSA  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent health;Advocacy;Attention;Attitude;Award;Black race;career;cohort;Collaborations;Communities;community based participatory research;Disparity;eleventh grade;empowerment;ethnic minority population;Exclusion;experience;Faculty;faculty mentor;First Generation College Students;Friends;Future;graduate school;Health;health disparity;Health Sciences;Health Services Research;high school;High School Student;Indigenous;Individual;Inequity;innovation;interest;Knowledge;Latinx;Lead;Leadership;Learning;Low income;lower income families;mentoring community;Mentors;Mentorship;Michigan;Minority;Modeling;next generation;ninth grade;novel;Outcome;Participant;peer;Play;Policies;Population;Process;programs;Public Health;racial minority population;Research;Research Methodology;Research Personnel;Role;Schools;Science;science education;Science, Technology, Engineering and Mathematics;scientific literacy;Scientist;Self Efficacy;skills;social media;Social Network;Social support;STEM career;STEM field;STEM research;student participation;student training;Students;summer research;tenth grade;Time;Training;Translating;undergraduate student;Underrepresented Minority;underrepresented minority student;virtual;Voice;Work;Youth

PROJECT_TITLE: #MYHealth: Training the Next Generation of Health Scientists Through Participatory Research in Adolescent Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Diabetes;Digestive Diseases;Genetics;Human Genome;Nutrition;Obesity;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related death in the United States with a 5-year survival rate of 10%. Despite the rapid rise in the nationwide prevalence of obesity, a major risk factor for PDAC, how obesity drives PDAC progression is not known. In this project, we seek to define the mechanisms by which obesity promotes pro-tumorigenic hormone expression in the endocrine pancreas to elucidate targets for the development of novel PDAC therapies.

PI_NAMEs: GARCIA, CATHY  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Acinar Cell;Address;Adult;B cell differentiation;B-Lymphocytes;Beta Cell;Binding;Cancer Biology;Cancer Etiology;career;cDNA delivery;cDNA Expression;Cells;Cessation of life;Cholecystokinin;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;Computer software;computerized tools;congenic;Data;Dependovirus;Development;Developmental Biology;Disease;Duct (organ) structure;Educational workshop;Endocrine;Endocrinology;Environment;epidemiology study;Exhibits;Exocrine pancreas;experimental study;gain of function;Gene Expression;gene repression;Generations;Genes;Genetic;genetic manipulation;Genetic Models;Genetic Transcription;Goals;High Fat Diet;hormonal signals;Hormones;Human;Immunofluorescence Immunologic;in silico;In Vitro;in vivo;Insulin;insulinoma;Intercept;islet;islet amyloid polypeptide;Islet Cell;Islets of Langerhans;knock-down;KRAS oncogenesis;Label;Lead;loss of function;Malignant neoplasm of pancreas;Mentors;Mentorship;Methods;Modeling;Molecular;mouse model;multidisciplinary;Mus;Nerve Growth Factors;Neuropeptides;Non obese;novel;Obese Mice;Obesity;overexpression;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pancreatic Injury;pancreatic tumorigenesis;Physiological;Play;Preparation;Prevalence;prevent;Proliferation Marker;promoter;Quantitative Reverse Transcriptase PCR;receptor;Research;Resources;response;Risk;Risk Factors;RNA Interference;Role;Scientist;Signal Transduction;single-cell RNA sequencing;skills;small hairpin RNA;Source;Specific qualifier value;Survival Rate;symposium;Tamoxifen;Technical Expertise;Testing;Training;transcription factor;Transcription Repressor;transcriptome sequencing;transdifferentiation;Tumor Burden;tumor initiation;tumor progression;tumorigenesis;tumorigenic;United States;Up-Regulation;Viral;Work

PROJECT_TITLE: Elucidating mechanisms of endocrine-exocrine signaling in obesity-driven pancreatic cancer


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ROCHESTER

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE The retinal pigment epithelium-choriocapillaris complex in the eye is compromised in several retinal degenerative diseases. However, there is currently lack of physiologically relevant human outer retina cell model(s). In this proposal, we will use human induced pluripotent stem cell-derived cells and engineered extracellular matrices to generate retinal pigment epithelium-choriocapillaris tissue mimetics for subsequent use in disease modeling, drug screening, and transplantation studies.

PI_NAMEs: BENOIT, DANIELLE S.;SINGH, RUCHIRA  (contact)

PROJECT_TERMS: 3-Dimensional;Adhesives;Adult;Age related macular degeneration;Age Years;American;Architecture;Biochemical;Biology;Biophysics;Blindness;Blood capillaries;Blood Vessels;Blood-Retinal Barrier;Bruch's basal membrane structure;Cell Communication;Cell Death;Cell model;Cell secretion;cell type;Cells;Choroidal Neovascularization;Clinical;Complex;Cues;Data;Degenerative Disorder;density;Deposition;Development;Diameter;Diffusion;Disease;disease model;Drug Screening;Drusen;Elasticity;Embryo;Encapsulated;Endothelial Cells;Endothelium;Engineering;Epithelial Cells;epithelial stem cell;ethylene glycol;Extracellular Matrix;Eye;Eye diseases;Functional disorder;Gel;Growth Factor;Health;histological studies;Human;human induced pluripotent stem cells;Hydrogels;Impairment;In Vitro;in vitro Model;in vivo;Individual;induced pluripotent stem cell;Lead;Matrix Metalloproteinases;Mediating;Membrane;Mesenchymal Stem Cells;Mesenchyme;microfluidic technology;Microfluidics;mimetics;Modeling;Modulus;monolayer;Morphogenesis;Morphology;multidisciplinary;Neural Retina;Nutrient;Outcome Measure;Pathologic;Pathology;Patients;Pattern;Peptides;Perfusion;Phagocytosis;Phenocopy;Photoreceptors;Physiological;Physiology;Pigmentation physiologic function;Property;Proteomics;Qualifying;Retina;Retinal Degeneration;Retinal Pigments;retinogenesis;shear stress;Structure;Structure of retinal pigment epithelium;Testing;Tissue Model;Tissues;transcriptomics;Transplantation;Vascular blood supply;Vascular Endothelial Growth Factors;Vertebrates;Vision

PROJECT_TITLE: Using hiPSCs to develop physiologically-relevant outer retina tissue mimetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(02)]


NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Neurosciences;Prevention;Stroke

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Public health narrative Identifying the specific cause of stroke enables doctors to tailor treatment to minimize risk of future strokes; for example, targeted treatment of atherosclerosis of arteries or clots in the heart. However, the cause of stroke remains unknown in a large group of patients who can benefit from tailored treatment if better diagnostic methods were available. This project develops an advanced MRI-based stroke etiology diagnostic model to identify if atherosclerosis or heart clots are causative of stroke for many of the cases where current diagnostic testing cannot identify the stroke source.

PI_NAMEs: AKOUM, NAZEM ;MOSSA-BASHA, MAHMUD  (contact);TIRSCHWELL, DAVID L;YUAN, CHUN

PROJECT_TERMS: Acute;Algorithmic Analysis;Algorithms;Arrhythmia;Arteries;Artificial Intelligence;Atherosclerosis;Atrial Fibrillation;Cardiac;cardiac magnetic resonance imaging;Categories;Cause of Death;Cephalic;Cerebral Infarction;Cerebrum;Classification;Clinical;clinical imaging;clinical practice;Coagulation Process;deep learning;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Diagnostic tests;embolic stroke;Etiology;Event;follow-up;Functional disorder;Future;Goals;Healthcare Systems;Heart;Heart Atrium;heart rhythm;Hospitals;Image;Image Analysis;imaging modality;Imaging Techniques;improved;individualized medicine;Intervention Trial;Ischemic Stroke;Left;Lesion;Lifelong disability;Literature;Machine Learning;Magnetic Resonance Imaging;Medicine;Modeling;novel;optimal treatments;Pathology;Patients;Pattern;personalized medicine;predictive modeling;Prevention Measures;Prospective Studies;Protocols documentation;Public Health;Randomized;Recurrence;Risk;risk minimization;Scheme;Secondary Prevention;Source;standard of care;Statistical Models;Stenosis;Stroke;stroke patient;Subgroup;targeted treatment;Techniques;Testing;Training;treatment strategy;treatment trial;United States;Universities;Validation;Washington

PROJECT_TITLE: Quantitative model-based ESUS reclassification using cardiac and cerebral vessel wall MRI

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Breast Cancer;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Neuroblastoma;Neurosciences;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: Pasadena

ORG_NAME: SPATIAL GENOMICS, INC.

PHR: NARRATIVE Understanding cell-to-cell interactions in tumors is critical for clinical diagnostics and medical research. Spatial Genomics has developed a technology to map cell populations and molecular states of single cells in the native tumor microenvironment. This technology can identify cell types and the spatial interactions between immune cells and tumors cells in the tissue to generate a spatial map with molecular information.

PI_NAMEs: FRIEDA, KIRSTEN  (contact)

PROGRAM_OFFICER_NAME: LOU, XING-JIAN

PROJECT_TERMS: Acceleration;Address;Adoption;Antibodies;antibody conjugate;Bar Codes;Biological Markers;Biopsy Specimen;cancer biomarkers;Cancer Diagnostics;cancer imaging;Cell Communication;cell type;Cells;Clinical;clinical diagnostics;commercialization;Complement;Complex;Computer software;CTLA4 gene;cytokine;Data;Development;Diagnostic;Diagnostics Research;Disease Progression;Epidermal Growth Factor Receptor;exhaustion;experimental study;Fibroblasts;flexibility;Fluorescent in Situ Hybridization;Gene Order;Genes;Genetic Markers;Genomics;Geographic Distribution;Geography;Glioblastoma;human imaging;Hypoxia;Image;Immune;Immune Targeting;Immunofluorescence Immunologic;In Situ;in-vitro diagnostics;instrument;instrumentation;Malignant Breast Neoplasm;Mammary Neoplasms;Maps;Marketing;Medical Research;Messenger RNA;Methods;Molecular;molecular marker;Molecular Profiling;multiple omics;Neighborhoods;neoplastic cell;Neuroblastoma;Nucleic Acids;Oligonucleotides;Pathology;Phase;Population;Population Heterogeneity;Post-Translational Protein Processing;Process;Processed Genes;programmed cell death protein 1;Proliferating;Proteins;ratiometric;Reagent;receptor;Research;Research Personnel;Resolution;RNA;Sampling;Scanning;Signal Pathway;Signal Transduction;single molecule;Slice;Slide;Spatial Distribution;System;Technology;Testing;Time;Tissues;tool;Transcript;tumor;tumor growth;tumor microenvironment;Tumor Subtype;Tumor Tissue;Validation;Visualization

PROJECT_TITLE: Spatial genomics analysis of tumor samples


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Lacrimal deficiency is associated with many ocular or systemic diseases. This proposal will characterize the role of a newly-identified neuronal population in the superior salivatory nucleus in controlling lacrimation. These studies will advance our understanding of the neural mechanisms behind lacrimation and unravel new drug targets for treating lacrimal deficiency.

PI_NAMEs: LIU, QIN  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Ablation;Address;Afferent Pathways;Allergens;Autonomic Dysfunction;Axon;Biological Assay;Bombesin Receptor;Brain Stem;Calcium;Cell Nucleus;Clinical;Disease;Efferent Pathways;Electrophysiology (science);Etiology;experimental study;Eye;Eye diseases;eye dryness;Fiber;Functional disorder;Future;Ganglia;Genetic;Image;Infection;insight;Irritants;irritation;Knowledge;lacrimal;Lacrimation;Lead;loss of function;Lubrication;Lupus;Mediating;microbial;Molecular;Mus;Nerve;neural circuit;neuromechanism;Neuronal Dysfunction;Neurons;neurotransmitter release;new therapeutic target;novel;ocular surface;optogenetics;pathogen;Pathway interactions;pharmacologic;Physiological;Pilot Projects;Population;Population Control;Preganglionic Autonomic Fibers;Property;Reflex action;Research;response;Role;saliva secretion;Sensory;sensory input;Signal Transduction;Sjogren's Syndrome;Synapses;Systemic disease;Testing;transmission process;Virus Diseases

PROJECT_TITLE: Neural Circuits Controlling Lacrimation


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Microbiome;Precision Medicine;Prevention;Radiation Oncology;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative The objective of this study is to define novel dosimetric predictors of female sexual dysfunction and to identify quantitative imaging and microbiome-based biomarker indices associated with radiation damage to specific sexual organs using a classification of sexual dysfunction structured on functional anatomic domains (dermatologic, vaginal and erectile). Towards this end, we will conduct an observational prospective cohort study of 110 female patients treated with pelvic radiation at institutions in New York City, Atlanta, and Houston. Our results will rapidly provide data and inform innovative, personalized interventions to preserve female sexual function or mitigate the effects of radiation in this understudied population.

PI_NAMEs: MARSHALL, DEBORAH CATHERINE (contact)

PROJECT_TERMS: Acceleration;Adverse event;Anatomy;Appointment;Area;Arousal;base;Biological;Biological Assay;Biological Markers;Biometry;Cancer Patient;Cancer Survivor;cancer therapy;career development;Classification;Clinical;Clinical Research;clinical risk;clinically relevant;cohort;Creativeness;Data;Dedications;Dermatologic;design;Devices;didactic education;Dose;Ecology;Effectiveness;Environment;experience;fecal microbiome;Female;Functional disorder;Funding;Future;gastrointestinal;Gastrointestinal Diseases;Grant;gut microbiome;Human;imaging biomarker;Imaging Techniques;improved;improved outcome;indexing;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;Internal Medicine;Intervention;Joints;Knowledge;Lead;Leadership;life span;Longitudinal cohort;Malignant Neoplasms;Measures;medical schools;Medical Students;Mentors;microbiome;microbiome alteration;Mucous Membrane;multidisciplinary;New York City;Normal tissue morphology;novel;Organ;Orgasm;Outcome;Patient Outcomes Assessments;Patients;Pelvic Cancer;Pelvis;Personal Satisfaction;personalized approach;personalized intervention;personalized therapeutic;Population;population health;Positioning Attribute;Predisposition;preservation;prevent;Prevention approach;professor;Program Development;programs;prospective;Prospective, cohort study;Protocols documentation;Publishing;Quality of life;quantitative imaging;Radiation;radiation adverse effect;Radiation Dose Unit;radiation effect;Radiation induced damage;Radiation Oncology;Radiation therapy;Radiation Toxicity;Research;Research Methodology;Research Personnel;Resource Sharing;response;Secure;Sex Behavior;Sex Functioning;Sexual Dysfunction;sexual role;Structure;Supportive care;Testing;Therapeutic Intervention;Time;Tissues;Toxic effect;Training;treatment planning;Vagina;vaginal microbiome;Vision;Wages;Woman;women patients;Women's cohort

PROJECT_TITLE: Novel Functional Anatomic and Biomarker Indices of Radiation-Induced Female Sexual Toxicities in a Multi-Center Cohort


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rural Health;Social Determinants of Health

PHR: NARRATIVE The ECHO AWARE (ECHO in Agricultural Washington and Rural Environments) project enriches the diversity of the ECHO Cohort with participants from a rural, agricultural community with a high proportion of Latino individuals. Research activities are designed to improve health of rural children; answer important questions regarding exposures of all children to common air pollutants, pesticides, and drinking water hazards; and directly inform US policy and programs. The project engages local students, community health service partners, and junior scientists to increase the diversity of perspectives in the ECHO Program as well as the impact of the research.

PI_NAMEs: KARR, CATHERINE J (contact)

PROGRAM_OFFICER_NAME: LAESSIG, SUSAN ALISON

PROJECT_TERMS: Acceleration;access disparities;Address;Adverse effects;Affect;Age;agricultural community;Agriculture;Air;Air Pollutants;Air Pollution;Animal Model;Award;Awareness;Behavior;biobank;Birth;built environment;burden of illness;career;career development;Chemical Exposure;Chemicals;Child;Child Health;Childhood;climate change;Clinic;cohort;Collection;Communication Tools;Communities;community engaged research;community engagement;Community Health Services;community research;Conceptions;Consultations;Cultural Backgrounds;Data;Data Collection;design;Development;Discipline;Disparity;Documentation;Dose;drinking water;early life exposure;Economics;Effectiveness;effectiveness evaluation;Enrollment;Environmental Epidemiology;Environmental Exposure;environmental justice;epidemiologic data;Event;experience;experimental analysis;Exposure disparity;Exposure to;Face;Faculty;Family;farm worker;Federally Qualified Health Center;Fertility;fine particles;Fostering;hazard;Health;health disparity;Health Promotion;Home;improved;indexing;Individual;insight;Institution;Investigation;Knowledge;Latino;Latino Population;Lead;Leadership;Life;Manuscripts;Medical;Methods;minority communities;Modeling;modifiable risk;Mothers;multidisciplinary;Natural experiment;novel;Outcome;Paper;Participant;peer;Pesticides;Phase;Policies;pollutant;Poly-fluoroalkyl substances;Population;Positioning Attribute;Pregnancy;pregnant;prenatal;Productivity;programs;Protocols documentation;Public Health;recruit;Research;Research Activity;Research Design;Research Personnel;resilience factor;Resources;respiratory health;response;Risk;Risk Factors;Role;Rural;rural America;Rural Community;rural environment;Rural Health;Rural Minority;sample collection;Science;Scientist;Series;Site;Smoke;sociodemographics;spatiotemporal;Students;success;tool;Translations;ultrafine particle;Uncertainty;undergraduate student;Universities;Washington;well water;Wildfire;Yakama Indian;Yakima Valley

PROJECT_TITLE: ECHO in Agricultural Washington and Rural Environments (ECHO AWARE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Mental Health;Mental Illness;Neurosciences;Suicide

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

PHR: Narrative The focal point of this project is to understand how the astrocytic transcription factor, NFIA, affects the amygdala circuit activity and function. Given that amygdala is linked to various psychiatric diseases such as anxiety, depression, and suicide, this project is to reveal new mechanisms that can be applied to the understanding and possible treatment of these psychiatric disorders.

PI_NAMEs: WOO, JUNSUNG  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Adult;Affect;Age;Amygdaloid structure;Anxiety;anxious behavior;Astrocytes;autism spectrum disorder;Automobile Driving;Behavior;Behavioral;Blood flow;Brain;Brain region;Cell Nucleus;ChIP-seq;Data;Depressed mood;depressive behavior;Depressive disorder;depressive symptoms;Emotions;Enzymes;excitatory neuron;Functional disorder;gain of function;gamma-Aminobutyric Acid;Gene Expression;gene network;Genes;Genetic;genetic approach;Genetic Transcription;Glial Fibrillary Acidic Protein;Goals;Hippocampus;Homeostasis;Human;inhibitory neuron;Knock-out;Link;loss of function;Measures;Mental Depression;Mental disorders;Metabolic;Modeling;Molecular;Monoamine Oxidase B;Morphology;mouse model;Mus;Neuroglia;neuronal circuitry;neuronal excitability;Neurons;NFIA gene;Output;Pathway interactions;pharmacologic;Physiological;Physiology;Play;promoter;prospective;Psychiatric therapeutic procedure;Regulation;Reporting;Role;Sampling;Schizophrenia;Suicide;Synaptic Transmission;tool;transcription factor;transcriptome sequencing

PROJECT_TITLE: Astrocyte regulation of amygdala circuit function

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE  Parkinson’s disease (PD) is highly prevalent and associated with significant disability and mortality, but the neural mechanisms underlying its pathophysiology are still unclear. In the long-term, we seek to clarify the contribution of sensory feedback to the generation of pathological motor outputs in PD. A more complete model of both motor and sensory dysfunction in PD will enhance our fundamental understanding of this disease and help accelerate the pace of innovation in its treatment.

PI_NAMEs: IRWIN, ZACHARY THOMAS (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acceleration;Affect;Age;arm;arm movement;associated symptom;Automobile Driving;Basal Ganglia;Behavioral;Biological Markers;Bradykinesia;Brain;clinical biomarkers;Clinical Management;clinical practice;Conscious;Data;Deep Brain Stimulation;Development;disability;Disease;Disease Outcome;Feedback;Frequencies;Functional disorder;Future;Generations;Goals;Human;Impairment;implantation;improved;improved outcome;Individual;innovation;insight;Lead;limb movement;Maps;Measures;Modeling;mortality;Motor;Motor output;motor symptom;Movement;Muscle;Muscle Hypertonia;neural;neural circuit;Neurodegenerative Disorders;neuromechanism;Noise;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Parkinson Disease;Pathologic;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Postoperative Period;Prediction of Response to Therapy;prevent;Process;Production;Property;Provider;Reaction;Reflex action;Research;response;Rest;Role;Sensory;sensory feedback;Sensory Ganglia;sensory input;sensory integration;Specific qualifier value;Symptoms;System;Technology;Testing;Therapeutic;Time;Treatment Efficacy;Tremor

PROJECT_TITLE: Impaired sensory filtering as a mechanism of Parkinson's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Palliative Care;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative In lower-and-middle income countries (LMICs) like Thailand, up to 40% of family members providing care for adults with chronic disorders experience mental health risks such as depression, anxiety, and/or psychological stress but have significantly more limited access to mental health care compared to the Western countries. Lack of treatment for caregiver mental health can lead to other adverse consequences for both caregivers and patients, including caregiver burnout, patient abuse, losing employment and elevated financial strain as well as worsening of health conditions of care recipients. This project is designed to develop and test a culturally informed mobile health program that will deliver an evidence-based intervention to reduce mental health problems in family caregivers of adults with chronic disorders in Thailand, which, if successful, can potentially benefit over five million of family caregivers in Thailand.

PI_NAMEs: CHEN, HONGTU  (contact);CHUENGSATIANSUP, KOMATRA ;LEVKOFF, SUE E

PROJECT_TERMS: Activities of Daily Living;Adult;adverse outcome;Anxiety;Behavioral;burnout;care recipients;care seeking;caregiver interventions;Caregivers;caregiving;Caring;Chronic Disease;Clinical;Communities;comparison control;Computer software;coping mechanism;Country;Death Rate;depressive symptoms;design;Development;Diagnosis;digital health;digital mental health;Distress;Early Diagnosis;Early Intervention;Effectiveness;effectiveness evaluation;eHealth;Employment;Ensure;evidence base;Evidence based intervention;experience;experimental arm;fall risk;Family Caregiver;Family member;Financial Hardship;formative assessment;Frequencies;Goals;Health;health care delivery;Health Technology;improved;Income;Individual;innovation;Institutionalization;Intervention;Interview;literacy;low and middle-income countries;Mental Depression;Mental disorders;Mental Health;Mental Health Services;mHealth;mobile application;mobile computing;Mobile Health Application;Outcome;Output;Participant;Patients;Persons;Phased Innovation Awards;prevent;Prevention;Privacy;programs;Provider;psychological distress;Psychological Stress;Qualitative Research;randomized, clinical trials;Reporting;Research;Risk;routine care;Self Care;Self Efficacy;social culture;social stigma;sociocultural determinant;stressor;success;Technology;technology intervention;Testing;Thailand;Training;usability;Western World

PROJECT_TITLE: Mobile application for early detection and intervention to reduce psychological distress in informal family caregivers of community dwelling adults with chronic disorders in Thailand


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Public Health relevance: This proposal will discover novel targets to treat insulin resistance in obese patients.

PI_NAMEs: NIKOLOVA-KARAKASHIAN, MARIANA N (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Address;Adipose tissue;Adverse effects;Affect;Animal Disease Models;Animal Model;Antibodies;Autophagocytosis;Biochemical Pathway;Biological;Cell membrane;Ceramides;Clinic;clinically relevant;Data;Development;Diabetes Mellitus;Diet;Drug Targeting;Effectiveness;endoplasmic reticulum stress;Enzymes;experimental study;Fatty acid glycerol esters;Fatty Liver;FOXO1A gene;gain of function;Gene Expression;Generations;Genes;Genetic;Gluconeogenesis;Health;Hepatic;Hepatocyte;Homeostasis;Human;Hydrophobicity;Hyperglycemia;Hyperinsulinism;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Insulin;insulin regulation;Insulin Resistance;insulin signaling;Knockout Mice;Link;lipid biosynthesis;lipidomics;Lipids;Liver;Location;loss of function;Mediating;Metabolic;Metabolic Pathway;Metabolic syndrome;Metabolism;mitochondrial dysfunction;Molecular;Mus;Muscle;mutant;Names;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;obese patients;Obesity;Organelles;Palmitic Acids;Pathway interactions;Peripheral;Persons;pharmacologic;Physiological;Play;preclinical study;prevent;Production;protein kinase C zeta;Protein phosphatase;public health relevance;Regulation;Research;response;Role;saturated fat;Signal Transduction;Site;Solid;Sphingolipids;Sphingomyelinase;Sphingomyelins;sphingosine 1-phosphate;Testing;Tissues;Translations

PROJECT_TITLE: Signaling and metabolic functions of nSMase-2 in hepatic steatosis and onset of insulin resistance


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Black patients with end-stage liver disease receive fewer than 10% of all living donor liver transplants, and efforts to redress these disparities are urgently needed to save their lives. The objective of the proposed study is to assess multi-level factors contributing to racial disparities in access to living donor liver transplantation. Study results will inform the development of a culturally sensitive, multi-level, transplant center-based intervention to increase Black patients’ access to living donor liver transplantation.

PI_NAMEs: GORDON, ELISA J (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: access disparities;Address;Affect;black patient;Black Populations;Black race;Caregivers;Chronic Disease;Clinical;Databases;Decision Making;Development;Disparity;Donor person;Donor Selection;effective therapy;end stage liver disease;Equity;ethnic disparity;experience;Fostering;Goals;health record;implementation science;Improve Access;Income;informant;Insurance;Intervention;Interview;Kidney Transplantation;Knowledge;Learning;Life;Link;Liver;liver transplantation;Living Donor Liver Transplantation;Living Donors;living kidney donor;Mediating;Medical;Methods;Monitor;Neighborhoods;North Carolina;Organ;patient population;Patients;Perception;Persons;Play;Process;prospective;racial disparity;Racial Equity;racial minority;Reporting;Research;Retrospective cohort;Retrospective Studies;Risk;social health determinants;Source;System;therapy design;Time;Time Study;transplant centers;Transplant Recipients;Transplantation;United States National Academy of Sciences;Waiting Lists;Weight;Work

PROJECT_TITLE: Assessing Multi-level Barriers to Racial Equity in Living Liver Donor Transplantation


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Food Allergies;Maternal Health;Nutrition;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Prior studies are conflicting in the effect of maternal diet including or excluding egg and peanut on development of egg and peanut allergy in infancy, and randomized controlled trials are lacking. In this proposal, we will define the role for egg and peanut exposure during pregnancy, through human milk and house dust in food sensitization in infancy and identify the biomarkers leading to tolerance of sensitization. Knowledge gained from these studies will uncover mechanisms of early-life sensitization necessary to establish maternal dietary guidelines in prevention of food allergy and the atopic march.

PI_NAMEs: JARVINEN-SEPPO, KIRSI  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Academy;Address;Adult;Age Months;airborne allergen;Allergens;Allergic;Allergic Reaction;Allergic rhinitis;Allergy to eggs;Allergy to peanuts;American;Anaphylaxis;Antibodies;Antigen-Antibody Complex;Antigens;arm;Asthma;Atopic Dermatitis;Basophils;Biological;Biological Markers;Black race;Blood;Breast Feeding;Cattle;Cellular Phone;Child;Childhood;Clinical;cohort;Consumption;crosslink;Data;Development;Diet;dietary;dietary guidelines;dietary restriction;Disease;Dose;egg;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Exclusion;Exposure to;feeding;Feeds;Fetus;First Degree Relative;Food;Food Hypersensitivity;General Population;Heredity;high risk;high risk infant;high risk population;Home;Homing;House Dust;Household;Human Milk;Hypersensitivity;IgE;IgG4;Immune response;Immune system;Immunoglobulin A;Immunoglobulin G;in utero;infancy;Infant;Ingestion;Knowledge;Lactation;Life;Life Style;Mediating;microbial;Milk;Modernization;mother nutrition;Mothers;novel;offspring;Oral;Outcome;Participant;Pediatrics;Perinatal;Peripheral Blood Mononuclear Cell;Population;Pregnancy;Pregnant Women;Prevalence;Prevention;Prevention strategy;primary outcome;Primary Prevention;Randomized;Randomized, Controlled Trials;recruit;response;Risk;Risk Assessment;Risk Factors;Role;Sampling;School-Age Population;secondary outcome;Skin;social media;Solid;Surveys;T cell response;T memory cell;T-Lymphocyte;Testing;trial design

PROJECT_TITLE: Expecting Mothers' Study of Consumption or Avoidance of Peanut and Egg (ESCAPE)