NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Public Health Relevance/ Project Narrative This project develops and tests new devices to measure the concentration of oxygen and carbon dioxide as well as the acid-base status of human blood. Measurements like this are made many times per day in patients with respiratory failure, circulatory shock, and many other conditions leading to critical illness and care in the intensive care unit. The new devices will provide the capability for accurate, frequent measurements at the bedside with immediate results, which will greatly improve upon existing techniques and provide critical tools to clinicians caring for hospitalized patients.

PI_NAMEs: AGUIRRE, AARON D;EVANS, CONOR LEE (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acid-Base Imbalance;Acids;Acute;Address;Air;Animal Model;Animals;Arterial Lines;Back;base;Benchmarking;Biological Models;Blood;Blood gas;Blood Gas Analysis;blood gas analyzer;Blood specimen;Blood Volume;Calibration;Carbon Dioxide;Caring;Catheters;Cells;Clinical;Clinical Medicine;Collaborations;cost;Critical Care;Critical Illness;design;Development;Device or Instrument Development;Devices;Diagnosis;Disasters;Disease;effective therapy;Engineering;Evolution;experience;experimental study;Family suidae;Fiber;Fiber Optics;Frequencies;Gases;Goals;health care settings;Health Personnel;hospital laboratories;Hospitalization;Hospitals;Hour;Human;Human Resources;implantable device;improved;innovation;insight;Intensive Care Units;Laboratories;Life;light weight;Manuals;Measurement;Measures;Mechanical ventilation;Medical;Medicine;Metabolic;Methods;miniaturize;miniaturized device;Modern Medicine;Modernization;Molecular;Monitor;new technology;next generation;novel;Operative Surgical Procedures;Optics;Oxygen;Patient Care;Patient Monitoring;Patients;Photochemistry;photonics;Physiological;point of care;point of care testing;porcine model;pre-clinical;prevent;Process;programs;prototype;public health relevance;Reader;Reporting;research and development;Research Personnel;Resolution;respiratory;Respiratory Failure;Running;Sampling;Sampling Studies;sensor;sensor technology;Shock;System;Techniques;technological innovation;Technology;technology platform;Testing;Time;Titrations;tool;Training;Translational Research;Translations;Tube;Venous;ventilation;Ventilator;wearable device

PROJECT_TITLE: Blood Gas Analysis Without the Laboratory

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: PROJECT NARRATIVE OF PARENT K08 To improve alcohol use disorder treatment, particularly through precision medicine approaches, it is imperative that alcohol use disorder etiologic mechanisms are identified and assessed in a way that is reliable and valid across diverse groups of individuals. The proposed study will use a multimethod approach to develop and  validate a computerized adaptive test of alcohol use disorder etiologic mechanisms. Ultimately, the goal of this  work is to establish an efficient and comprehensive assessment of mechanisms that can be used in service of  determining the optimal treatment, whether behavioral, pharmacological, or both, for a given person with  alcohol use disorder. PROJECT NARRATIVE FOR PROPOSED ADMINISTRATIVE SUPPLEMENT This project proposes an administrative supplement to support the principal investigator’s return to full productivity following time-limited period of parental leave. The proposed supplement will provide additional personnel support which will facilitate progress towards the parent award’s overall goal of improving alcohol use disorder treatment through precision medicine approaches by enhancing the identification and assessment of the factors that cause and maintain alcohol use disorder.

PI_NAMEs: BONESS, CASSANDRA LEE (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: addiction;Address;Administrative Supplement;alcohol abuse therapy;Alcohol consumption;alcohol testing;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Articulation;Award;Behavioral;Calibration;Clinical;cognitive control;cognitive interview;Communities;community based participatory research;computerized;Consultations;Data;data management;Development;Diagnosis;Ecological momentary assessment;Emotional;Ensure;Etiology;follow up assessment;Gender;Goals;graduate student;Heterogeneity;Human Resources;improved;indexing;Individual;Intervention;K-Series Research Career Programs;Literature;Lived experience;Measurement;Measures;Mentors;Methods;Modeling;Modernization;National Institute on Alcohol Abuse and Alcoholism;optimal treatments;parent project;Parental Leave;Parents;Participant;Pathology;patient population;Patient Self-Report;Persons;pharmacologic;Phenotype;precision medicine;Principal Investigator;Productivity;Property;Psychometrics;Public Health;Research;Research Activity;Research Domain Criteria;response;Rewards;Sampling;Scientist;Services;sex;Strategic Planning;Structure;Testing;theories;Time;Training;Validation;Wages;Work

PROJECT_TITLE: Measurement and Multimethod Validation of Alcohol Use Disorder Etiologic Mechanisms


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LAS CRUCES

ORG_DEPT: BIOLOGY

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

PHR: This project is focused on the continuing operation of the Molecular Vector Physiology Laboratory at New Mexico State University, its research- and educational mission.

PI_NAMEs: HANSEN, IMMO ALEX (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Applied Research;Area;Arthropods;Basic Science;Biological Models;Blood;Cell Physiology;Culicidae;Development;disease transmission;Disease Vectors;Education;Foundations;Health;Homeostasis;improved;Knowledge;Laboratories;Methods;Mission;Molecular;molecular vector;Mosquito Control;mosquito reproduction;New Mexico;novel;Nutrient;operation;Persons;Physiology;Population;Regulation;Research;Research Personnel;Research Project Grants;Signal Pathway;Students;sucking;undergraduate student;Universities;Water

PROJECT_TITLE: The Molecular Vector Physiology Laboratory at New Mexico State University

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Estrogen;Genetics;Heart Disease;Women's Health Research

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: Women’s health across the lifespan has recently been highlighted as a national research priority. Stiffening of the large arteries contributes to cardiovascular disease with aging, and it affects women differently than men in time course, severity, and clinical consequences. This project investigates the molecular mechanisms underlying sex differences in aging-associated arterial stiffness, with the aim to identify a novel therapeutic option to mitigate exacerbated arterial stiffness.

PI_NAMEs: TURNER, CASEY GAIL (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Address;Adult;Affect;Age;Age Months;aged;Aging;aging mechanism;aging related;Agonist;Animal Model;Aorta;Area;arm;arterial stiffness;Arteries;Atomic Force Microscopy;Bilateral;Blood Vessels;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;Cells;Chronic;Clinical;clinically significant;Collagen;Data;Development;disability;Disease Outcome;EFRAC;Elderly;ESR1 gene;Estrogens;Female;Fibrosis;Fulvestrant;Future;Gene Expression;Genes;Genetic;Gonadal Steroid Hormones;Health;health difference;Heart failure;Human;improved;In Vitro;in vivo;in vivo evaluation;innovation;Integrins;Isolated systolic hypertension;knock-down;Knockout Mice;Life;life span;Link;Literature;male;Mass Spectrum Analysis;Matrix Metalloproteinases;Measures;men;Menopause;middle age;Midlife women;Mission;MMP2 gene;Molecular;Molecular Biology;Morbidity - disease rate;mRNA Expression;Mus;National Heart, Lung, and Blood Institute;novel;novel therapeutics;Outcome Measure;Ovariectomy;Pathway interactions;pharmacologic;Physiologic pulse;Physiology;Positioning Attribute;Postmenopause;pre-clinical;Premenopause;preservation;prevent;Process;protein expression;Receptor Activation;receptor expression;receptor function;Receptor Inhibition;Renin-Angiotensin-Aldosterone System;Repression;Research;Research Priority;Role;Severities;sex;Sex Differences;sexual dimorphism;sham surgery;Signal Transduction;Small Interfering RNA;Smooth Muscle Myocytes;Strategic vision;Testing;Therapeutic;therapeutic evaluation;Time;Tissues;Training;Trichrome stain;Type 2 Angiotensin II Receptor;United States National Institutes of Health;Wild Type Mouse;Woman;women versus men;Women's Health;Women's mortality;Women's study;young man;young woman

PROJECT_TITLE: The Role of Smooth Muscle Cell Estrogen Receptor Alpha in Aging-Associated Arterial Stiffness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-B (20)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Liver Disease

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE In this proposal we aim to understand the impact of PD-L1 reverse signaling in the liver during acute infection and chronic disease. We will investigate consequences of PD-L1 reverse signaling to dendritic cell migration, activation and subsequent T cell priming in the setting of acute and chronic liver disease.

PI_NAMEs: TAMBURINI, BETH ANN (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Acute;acute infection;acute liver disease;adaptive immune response;Address;Affect;Alanine;Amino Acids;Antigen-Presenting Cells;Antigens;Bacterial Antigens;Binding;Biological Response Modifiers;cancer cell;CD8-Positive T-Lymphocytes;CD80 gene;cell injury;cell motility;Cell Physiology;cell type;Cells;Chronic;Chronic Disease;chronic infection;chronic liver disease;Cicatrix;cytokine;Cytolysis;Cytoplasm;Cytoplasmic Tail;Cytoprotection;Cytotoxic T-Lymphocytes;Data;Dendritic cell activation;Dendritic Cells;Disease;effector T cell;Environment;Epitopes;Event;exhaustion;extracellular;Extracellular Domain;Fibrosis;food antigen;Gene Expression;Genetic Transcription;Goals;Graft Rejection;Health;Hematopoietic;Homeostasis;Immune;Immune response;Immune Targeting;Immune Tolerance;Immunologics;improved;In Vitro;Induction of Apoptosis;Infection;Inflammation;Inflammatory;Innate Immune Response;Interferons;Listeriosis;Liver;Liver diseases;Liver Fibrosis;liver injury;lymph nodes;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Metabolic dysfunction;Modeling;Molecular;mouse model;Mutate;Mutation;novel;Organ;Outcome;Pathology;Phenotype;Population;Production;programmed cell death ligand 1;programmed cell death protein 1;protein protein interaction;Regulation;response;Role;Shapes;Signal Transduction;Steatohepatitis;Sterility;T cell response;T-Cell Activation;T-Lymphocyte;tissue repair;tumor progression;Vaccination;Virus Diseases

PROJECT_TITLE: PD-L1 reverse signaling in liver homeostasis and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-F (02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Maternal Health;Nutrition;Pediatric;Pregnancy;Women's Health Research

PHR: PROJECT NARRATIVE While hormones of fetal origin have long been postulated to regulate placental nutrient delivery, our laboratory recently produced the first direct evidence of this phenomenon with chronic (9-day) fetal glucagon infusions reducing uterine blood flow, placental nutrient transfer, and placental lactogen secretion. The goal of this proposal is to identify the physiological mechanism by which fetal glucagon regulates trophoblast function and thereby, placental delivery of nutrients. Furthermore, results from this proposal will identify a previously unknown adaptive strategy for matching nutrient delivery to fetal metabolic demand, thus improving survival in complicated pregnancies.

PI_NAMEs: TANNER, AMELIA RUTH (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Acidosis;Acute;Address;Amino Acids;Arteries;Blood flow;Catheters;Cells;Chronic;Circulation;Collaborations;Communication;Data;Decidua Basalis;efficacious treatment;Ensure;Estrogens;fetal;Fetal Growth;Fetal Weight;Fetus;Future;Glucagon;Glucose;Goals;Growth;Histologic;Hormones;Human;Hypoxia;IGF1 gene;improved;In Situ;in utero;in vivo;in vivo evaluation;in vivo Model;Infusion procedures;inhibitor;Insulin;Investigation;K-Series Research Career Programs;Laboratories;Lead;Link;Measurement;Mediating;Mentors;Metabolic;Metabolic hormone;Mothers;Myometrial;NOS3 gene;novel;Nutrient;Outcome;Oxygen;Physiological;Physiology;Placenta;Placental Lactogen;placental transfer;placental trophoblasts;Pregnancy;Pregnancy Complications;Pregnant sheep;Production;professor;Qualifying;Recombinants;Research;Resistance;response;RNA Interference;Role;Sampling;Sheep;Signal Transduction;skills;Surgical Instruments;targeted treatment;Techniques;tenure track;Testing;Training;trophoblast;uptake;Uterus;Vasodilation;Vasodilator Agents;Writing

PROJECT_TITLE: Assessing the mechanism by which fetal glucagon inhibits placental nutrient transfer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-J (20)]


NIH_SPENDING_CATS: Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_CITY: KANSAS CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Herpes simplex virus type 1 (HSV-1) establishes a lifelong, silent infection in sensory neurons, and occasionally is reactivated to cause diseases that range in severity from benign cold sores to encephalitis. The proposed studies focus on a novel immunoevasion mechanism of the immediate-early protein of the virus ICP0 that is mediated by its interaction with the endocytosis adaptor protein CIN85. The ICP0/CIN85 complex subjugates endocytosis and exocytosis pathways during HSV-1 infection in order to suppress the function of host proteins with antiviral activity, facilitating virus infection.

PI_NAMEs: LASNIER, SARAH  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Adaptor Signaling Protein;Affect;Afferent Neurons;Alzheimer's Disease;Anti-viral Response;Area;Astrocytes;Autophagocytosis;Benign;Binding;CBL Protein;Cell Culture Techniques;Cell Nucleus;Cell Surface Receptors;cell type;Cells;Charge;Classification;Communication;Complex;corneal epithelium;Cytoplasm;Data;design;Disease;Dissociation;Docking;Encephalitis;Endocytosis;endosome membrane;Endosomes;Ensure;Epidermal Growth Factor Receptor;Epithelial Cells;Exocytosis;exosome;experimental study;extracellular vesicles;Failure;Fibroblasts;Fingers;Ganglia;Gene Expression;Gene Expression Profile;gene repression;Genes;Genetic Transcription;Genome;Growth;Herpes Labialis;Herpesvirus 1;Herpetic Keratitis;high resolution imaging;HIV-1;host colonization;Human;imaging approach;Immediate-Early Proteins;Immune response;Impairment;Infection;Lesion;Light;Lysosomes;Lytic Phase;Maps;Mass Spectrum Analysis;Mediating;Membrane;Microglia;Modeling;Monitor;Morphology;Mucous Membrane;Multivesicular Body;mutant;Natural Immunity;Nature;Neurodegenerative Disorders;Neurons;novel;Nuclear;Parkinson Disease;pathogen;Pathway interactions;Peripheral;Phospholipids;Play;Population;Process;Productivity;protein function;Protein Sortings;protein transport;Proteins;Proteome;Proteomics;PVRL1;reactivation from latency;receptor;receptor internalization;recruit;Ring Finger Domain;Role;Scaffolding Protein;Severities;Side;Sorting;Specific qualifier value;Stress;Structure;Surface;Testing;trafficking;transcription factor PML;Travel;ubiquitin-protein ligase;Vesicle;vesicular release;Viral;viral DNA;Viral Genes;Viral Genome;Viral Physiology;Viral Proteins;Virus;Virus Activation;Virus Diseases;Virus Replication;Visualization

PROJECT_TITLE: The One Ring to Rule Them All: How ICP0’s Ring Finger in Alliance with the Host Protein CIN85 Regulates Protein Trafficking and Communication

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Genetics;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE This project will elucidate the spatiotemporal and molecular mechanisms of autoimmune CD8 T cell differentiation in Type 1 Diabetes. The proposed research will provide key insights for the development of novel therapies targeting T cells for prevention and treatment of Type 1 Diabetes and other T cell-mediated diseases.

PI_NAMEs: MIAKICHEVA, SVETLANA DMITRIEVNA (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: adult stem cell;Antibodies;ATAC-seq;Autoimmune;Autoimmune Diseases;Autoimmune Process;B-Lymphocytes;BACH2 gene;Beta Cell;blood glucose regulation;CD8-Positive T-Lymphocytes;Cell Communication;Cell Cycle Kinetics;Cells;chemokine receptor;clinically relevant;Complex;Cues;Data;design;Development;diabetes pathogenesis;Disease;Epigenetic Process;Equilibrium;gain of function;Generations;Genetic;Genetic Transcription;Hematopoietic;Homing;Hyperglycemia;Image;Image Cytometry;in vivo;Inbred NOD Mice;Incidence;Infiltration;innovation;insight;Insulin;Insulin deficiency;Insulin-Dependent Diabetes Mellitus;Integrins;Intestines;Lead;Location;Longevity;loss of function;lymph nodes;Mediating;member;Mesenchymal;migration;Molecular;mouse model;new therapeutic target;Pancreas;Pathogenesis;Pattern;Phenotype;Population;Positioning Attribute;Prevalence;prevent;Prevention;programs;Proliferating;Research;Role;self renewing cell;Self Tolerance;self-renewal;Signal Transduction;Signaling Molecule;spatiotemporal;stem;stem cells;stemness;T cell differentiation;T cell therapy;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Tissues;transcription factor;Transcription Repressor;transcriptome sequencing;transcriptomics;WNT Signaling Pathway

PROJECT_TITLE: Spatiotemporal and molecular determinants of autoimmune T cell stemness and differentiation in type I diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

PHR: PROJECT NARRATIVE Offspring born with fetal growth restriction (FGR) have increased incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) and periportal fibrosis. The goal of this proposal is to advance our understanding of the mechanism for increased periportal collagen deposition, a sign of developing fibrosis, in the liver of the fetus with FGR and the impact on future liver metabolic disease. Results from this proposal will be used to help understand how fibrosis develops in postnatal liver of FGR offspring and determine future mechanistic experiments to investigate fetal origins of hepatic fibrosis.

PI_NAMEs: MCGUCKIN, MOLLY  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Acetylcysteine;Adult;Age Months;Animal Model;Antioxidants;Bioinformatics;career;Cell Culture Techniques;Cell Separation;cell type;Cells;Centrilobular hepatic necrosis;Child;Childhood;Childhood Injury;Cholestasis;Chronic;cohort;Collagen;Data;Deposition;Development;Early identification;Endothelium;Event;experimental study;Exposure to;fetal;Fetal Development;Fetal Growth Retardation;Fetal Liver;Fetal Sheep;Fetus;fetus cell;fibrogenesis;Fibrosis;Future;Gene Expression Profile;Goals;Growth;Hepatic;Hepatic Stellate Cell;Hepatocyte;hepatocyte injury;high risk;Histologic;Histology;Human;Hypoxemia;Hypoxia;Immune;In Vitro;Incidence;insight;Investigation;K-Series Research Career Programs;Knowledge;Learning;Liver;Liver diseases;Liver Fibrosis;liver injury;liver metabolism;Measures;Mentors;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Modeling;Molecular;NADH;Neonatal;offspring;Outcome;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;pediatric patients;Phenotype;Physiology;Placental Insufficiency;postnatal;Predisposition;prevent;Production;professor;Reactive Oxygen Species;Regulation;Research Personnel;response;Risk;Role;Sampling;Scientist;sheep model;Signal Transduction;skills;Stains;Techniques;tenure track;Testing;Thiobarbituric Acid Reactive Substances;Tissues;Training;transcriptomics;United States National Institutes of Health;Writing

PROJECT_TITLE: Intrauterine mechanisms for liver metabolic disease in the growth-restricted fetus

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Tumor-associated macrophages (TAMs), derived from circulating monocytes, are among the most abundant immune cells in the tumor microenvironment and play an important role in suppressing immune responses and promoting cancer development, as well as in contributing to immune checkpoint blockade resistance. The proposed study seeks to understand how the cytokines macrophage-colony stimulating factor (M-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) differ in the induction of TAM-associated functional characteristics in differentiated cells, and whether early unique metabolic changes in monocytes are responsible. This work will enhance our understanding of critical functional differences between M-CSF and GM-CSF generated TAM-like cells and potentially highlight new metabolic mechanisms that regulate TAM-associated functions, which could ultimately benefit TAM-targeting cancer immunotherapies.

PI_NAMEs: XU, LILLIAN  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Address;Affect;angiogenesis;Biochemistry and Cellular Biology;Biological Assay;Cancer Biology;cancer cell;Cancer Cell Growth;cancer immunotherapy;cancer therapy;career development;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cell surface;Cells;Cellular Metabolic Process;Characteristics;ChIP-seq;Clinical;comparative;cytokine;Cytokine Activation;Cytokine Signaling;Data;Development;Disease Progression;doctoral student;Educational process of instructing;Educational workshop;Enzyme-Linked Immunosorbent Assay;Exhibits;experience;experimental study;extracellular;Flow Cytometry;Gene Expression;Generations;genome-wide;Granulocyte-Macrophage Colony-Stimulating Factor;Hour;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immune response;Immunology;Immunosuppression;improved;In Vitro;Inflammatory;inhibitor;Invaded;Investments;JAK2 gene;Knowledge;Link;lipidomics;Macrophage;Macrophage Colony-Stimulating Factor;Macrophage Colony-Stimulating Factor Receptor;Malignant Neoplasms;medical schools;Mentors;Metabolic;metabolic phenotype;Metabolism;metabolomics;Molecular;Molecular Biology;monocyte;Natural Immunity;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;peripheral blood;Physicians;Play;Process;Productivity;programmed cell death ligand 1;programs;receptor;Regulation;Reporting;Resistance;Resources;Role;Scientist;Shapes;Signal Pathway;skills;Stat2 protein;Stat5 protein;symposium;targeted treatment;Techniques;Testing;Therapeutic;Training;tumor;tumor microenvironment;Tumor-associated macrophages;Universities;Work

PROJECT_TITLE: Comparative analysis of M-CSF and GM-CSF in human monocyte metabolic reprogramming and differentiation into tumor-associated macrophage-like cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative The proposed project will expand our understanding of the formation of the optic network and the function of astroglia. This work will describe a novel structure of astroglia that occurs in development and define its function and interactions with other cell types.

PI_NAMEs: BARBER, HEATHER M (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Ablation;Affect;Appearance;Astrocytes;Axon;Behavior;Binding;Biological Assay;Biological Models;Brain region;Cell Nucleus;cell type;Cells;Contralateral;Cytoplasm;Data;Development;Developmental Process;Diameter;Dorsal;Excision;Fertilization;Fishes;Genetic;GLAST Protein;Head;Hour;Image;in vivo;in vivo imaging;Induced Neurons;Induction of Apoptosis;Infiltration;insight;Interleukin-1 beta;Invaded;Investigation;Label;Larva;Measures;Membrane;MERTK gene;meter;Microglia;Midbrain structure;Modeling;Molecular;Morphology;Movement;Nature;neural circuit;Neuroglia;neuron apoptosis;neuronal cell body;Neurons;novel;Nuclear;oligodendrocyte progenitor;Optics;Organism;Pathway interactions;Phagocytes;Phagocytosis;Phagosomes;pharmacologic;Population;Process;Radial;Research;Retinal Ganglion Cells;Role;Shapes;stem cells;Stretching;Structure;superior colliculus Corpora quadrigemina;Surface;Techniques;Testing;Time;tool;Transgenic Organisms;Travel;Ventricular;Vision;Visual;visual processing;Visualization;Work;Zebrafish

PROJECT_TITLE: Radial Astroglia Form Novel Structures to Engulf Neuronal Cell Bodies during Zebrafish Optic Tectum Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE People living in rural and other underserved areas, such as Appalachia, are more likely to experience disability, morbidity, and premature mortality; despite the increasing prevalence of newly acquired disabilities and their negative impact on the well-being of rural residents, we currently lack grounded perspectives on barriers and facilitators to optimal quality of life and health outcomes for people with disabilities. Consistent with NIH’s recent recognition of people with disabilities as a “health disparity population,” the proposed research will investigate diverse factors and circumstances that contributing to health inequities for rural, disabled, and underserved populations. This mixed methods research will expand knowledge of disability in Appalachia; identify gaps in health and human services; illuminate strategies to address individual, interpersonal, and community, and policy-level challenges; and inform the future development and implementation of interventions across the socioecological model to improve the lives of people with disabilities and their families.

PI_NAMEs: ROBERTS, MICHELLE KATHLEEN (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Acquired disability;Acute;Address;Affect;Appalachian Region;Caring;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;Communities;Complex;concept mapping;culturally appropriate intervention;Death Rate;Development;Diabetes Mellitus;Disabilities experience;disability;Disability outcome;disabled;Disabled Persons;Equipment;ethnographic method;Ethnography;Event;experience;Face;Family;Family Caregiver;family management;Focus Groups;follow-up;Formal caregiver;Future;Goals;Grant;Growth;Health;health care quality;health disparity populations;health equity;health inequalities;Healthcare;Healthcare Systems;Heart Diseases;Hospitalization;Human;implementation intervention;improved;Individual;Inequality;informal caregiver;informal caregiving;Injury;insight;Institution;Insurance;Intervention;Interview;Investigation;Kentucky;Knowledge;Left;Legal;Life Cycle Stages;Lived experience;low socioeconomic status;Malignant Neoplasms;Medical;Mental Health;Methods;Modeling;Morbidity - disease rate;Nature;Outcome;Participant;participant observation;Personal Satisfaction;Persons;Pharmaceutical Preparations;physical conditioning;Play;Policies;Policy Maker;Politics;premature;Premature Mortality;Prevalence;Preventive service;programs;psychosocial;Quality of life;Reduce health disparities;Research;Research Methodology;Research Personnel;Resources;Risk;Risk Factors;Role;Rural;Rural Appalachia;Rural Community;rural dwellers;rural health disparities;Rural Population;rural setting;service providers;Services;social;Social Change;social culture;Sorting;Stroke;structural determinants;Structure;Survivors;Training;Transportation;underserved area;Underserved Population;underserved rural area;Unemployment;United States National Institutes of Health;Writing

PROJECT_TITLE: From Survival to Living Well: A Socioecological Approach to Understand Acquired Disability and Advance Health Equity in Rural Appalachia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Contraception/Reproduction;Hypertension;Kidney Disease;Machine Learning and Artificial Intelligence;Pregnancy;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Renal fibromuscular dysplasia (FMD), a curable yet under-studied disease linked with increased morbidity and mortality rates, is associated with high blood pressure in pregnant women. Our goal is to use computational and machine learning techniques to examine kidney blood flow in FMD patients, with a focus on those also dealing with hypertension during pregnancy. Through this study, we hope to better understand this disease and potentially enhance the effectiveness of treatment strategies.

PI_NAMEs: DELBONO, LUCIANO  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Admission activity;Affect;Age;Aging;Angiography;Angioplasty;Anti-Hypertensive Agents;Architecture;Arteries;artery stenosis;Attention;Balloon Angioplasty;Blood flow;Blood Vessels;Cell Proliferation;Clinical;cohort;Computer Analysis;Data;Death Rate;demographics;Diagnosis;Diagnostic Procedure;diagnostic value;Disease;Disease Progression;Distal;Effectiveness;effectiveness evaluation;Evaluation;Event;Female;fetal;Fetus;Fibromuscular Dysplasia;glomerular filtration;Goals;hemodynamics;hospital readmission;Hyperemia;Hypertension;Image;improved;indexing;Intervention;Kidney;kidney vascular structure;Lesion;Life;Link;Liquid substance;Literature;Machine Learning;Measurement;Measures;Medial;Microvascular Dysfunction;Morbidity - disease rate;mortality;Mothers;novel;Outcome;Pathogenesis;patient variability;Patients;Pattern;Perfusion;Pharmaceutical Preparations;Population;post intervention;Pre-Eclampsia;Pregnancy;pregnancy disorder;Pregnancy Histories;Pregnant Women;preservation;pressure;Prevalence;primary outcome;Process;Property;Radiology Specialty;renal artery;Renal Artery Stenosis;Renin;Renovascular Hypertension;Reporting;Research Priority;Resistance;Resistant Hypertension;Risk;screening;Screening procedure;secondary outcome;Secondary to;Selection for Treatments;Stratification;successful intervention;Symptoms;Techniques;therapy outcome;Time;tool;Treatment Effectiveness;Treatment Efficacy;treatment strategy;United States National Institutes of Health;vascular bed;Woman;Work

PROJECT_TITLE: A Computational Analysis of Hemodynamics in Patients with Renal Artery Fibromuscular Dysplasia


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Aside from socioeconomic status, factors that drive heart health disparities among American young adults with type 1 diabetes are not well defined. Heart health is shaped by multiple intersections of social identities (gender, race, social class, disability) and discrimination stress. In this study, the links between social and environmental determinants of health, discrimination, and heart health will be explored as well as the lived experience of perceived discrimination among young adults with type 1 diabetes.

PI_NAMEs: HOWARD, QUIANA  (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Address;Adult;adult of color;Affect;Age;age group;aged;American;Area;Behavior;Black race;Blood Pressure;Body mass index;Cardiac health;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Chronic;Clinical;cohort;Community Health;Crowding;Diet;disability;Disadvantaged;Discrimination;Disease-Free Survival;Disparity;Enrollment;ethnic discrimination;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;Exposure to;Gender;Gender Identity;General Population;Glucose;Glycosylated Hemoglobin;Goals;Guidelines;Health;Health behavior;health determinants;health disparity;health equity;Healthcare Systems;high risk;high risk population;hospitalization rates;Housing;improved;Individual;Inequity;innovation;Insulin-Dependent Diabetes Mellitus;LDL Cholesterol Lipoproteins;Life Expectancy;Link;Lived experience;Longevity;Low income;marginalization;marginalized population;Mediating;Mediator;mortality;National Institute of Nursing Research;nicotine exposure;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Ohio;Outcome;Pathway interactions;Pattern;people of color;perceived discrimination;Physical activity;Population;Positioning Attribute;Poverty;prospective;Quality of life;Race;racial discrimination;racial minority;racial population;Reporting;Research;response;Risk;Risk Factors;Role;Shapes;Sleep;social;Social Class;Social Discrimination;social disparities;social health determinants;Social Identification;social vulnerability;Socioeconomic Status;Source;Strategic Planning;Stress;Subgroup;Training;Transportation;United States;Universities;University Hospitals;vulnerable community;Woman;young adult

PROJECT_TITLE: Young Adult with Type 1 Diabetes’ Discrimination Stress and Cardiovascular Health

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (89)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is a progressive neurodegenerative dementia that lacks reliable therapies to markedly slow disease pathology and its symptoms. Pathological tau protein deposition and propagation to various brain regions correlates strongly with cognitive decline in AD such that strategies to reduce tau burden may be an effective treatment. The research proposed in this fellowship aims to evaluate a novel in vivo approach for proteasomal activation to degrade tau, mitigate tau propagation, and alleviate neuronal loss as a potential therapy for AD.

PI_NAMEs: HU, MIWEI  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 26S proteasome;Acetylation;Affinity;Age;Age Months;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease therapy;Amyloid beta-Protein;Anatomy;Antibodies;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Astrocytes;astrogliosis;Autopsy;Axonal Transport;Biological Assay;Brain;Brain region;brain tissue;Cause of Death;Central Nervous System;Cerebral cortex;Chemistry;Clinical;Clinical Trials;Data;Dementia;Deposition;design;Deubiquitinating Enzyme;Disease;DNA Binding;effective therapy;Ensure;entorhinal cortex;Enzyme-Linked Immunosorbent Assay;Enzymes;Evaluation;Fellowship;Functional disorder;glial activation;Gliosis;Hippocampus;Hour;Human;Immunohistochemistry;Impaired cognition;Impairment;improved;In Vitro;in vivo;Injections;Interruption;Intraventricular;Label;Mass Spectrum Analysis;Mediating;Medicine;Memory Loss;Messenger RNA;Methods;MG132;Microglia;Microtubules;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Nerve Degeneration;neurodegenerative dementia;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;neuroinflammation;neuron loss;Neurons;novel;overexpression;Pathologic;Pathology;Pathway interactions;Patients;Phosphorylation;Physiological;prevent;Proteasome Inhibitor;protein aggregation;protein degradation;protein expression;Proteins;proteostasis;proteotoxicity;recruit;Research;Ribonuclease H;Role;Side;Single-Stranded DNA;Site;Specificity;Stains;Stereotyping;Stress;Symptoms;System;tau aggregation;tau mutation;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissues;tool;Toxic effect;transcriptome sequencing;transcriptomics;Transgenic Mice;treatment group;Ubiquitin;ubiquitin isopeptidase;ubiquitin-specific protease;Ubiquitination;United States;Wild Type Mouse

PROJECT_TITLE: Enhancing proteasomal activity and tau clearance via USP14 reduction in Alzheimer's Disease mouse models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: NARRATIVE Infants born with complex congenital heart disease (CHD) depend on surgical intervention for treatment, yet complications from synthetic materials used in reconstruction result in lifelong morbidity. Tissue engineered vascular grafts (TEVGs) are a promising solution, transforming into growing blood vessels, yet the LYST protein contributes to graft narrowing, the primary complication preventing the widespread clinical use of TEVGs. Understanding LYST's role in TEVG narrowing could facilitate the development of therapeutic methods to reduce complications in vascular grafts.

PI_NAMEs: TURNER, MACKENZIE  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: ADP Receptors;Antiplatelet Drugs;Autologous;Blood Platelets;Blood Vessels;Bone Marrow;Bone Marrow Cells;Bone Marrow Transplantation;Cell Lineage;cell motility;Cell Physiology;cell type;Cells;Cellular biology;Child;CHS1 gene;Clinical;Clinical Research;Coculture Techniques;Code;Collagen;Complex;Complication;congenital heart abnormality;Congenital Heart Surgery;cytokine;Cytoplasmic Granules;cytotoxic;Data;Deposition;Development;effective therapy;Exocytosis;experimental study;Extracellular Matrix;Flow Cytometry;Foreign Bodies;Foreign-Body Reaction;Functional disorder;gene function;Gene Mutation;Gene Proteins;Generations;Goals;healing;Histologic;Human;Immune;Immune signaling;immunoregulation;Impairment;Implant;implantation;improved;Incidence;Infant;Infiltration;Inflammation;Inflammatory;inflammatory marker;inflammatory milieu;Inflammatory Response;insight;Investigation;Knockout Mice;Legal patent;Macrophage;Mediating;Megakaryocytes;Mesenchymal;Methods;microCT;migration;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;next generation;Operative Surgical Procedures;Outcome;Patients;Phagocytosis;Phase;Phenotype;platelet function;Play;precursor cell;prevent;Production;Proliferating;Proteins;reconstruction;recruit;Regulator Genes;Repeat Surgery;research clinical testing;response;Role;scaffold;Shapes;Signal Transduction;Signaling Molecule;small molecule;Stenosis;Surgical Management;Therapeutic;therapeutic development;Thrombosis;Thrombus;Time;Tissues;Transplantation;tumor-immune system interactions;ultrasound;Vascular Graft;vascular tissue engineering;wound healing

PROJECT_TITLE: Elucidating the cellular and molecular basis of LYST-mediated TEVG stenosis


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cancer

ORG_CITY: SEATTLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Raf kinases are central components of many intracellular signaling networks in eukaryotes. Despite the role of mis-regulated Raf function and activity in numerous cancers, many fundamental aspects of Raf-mediated signaling are still poorly understood. Here, we will use chemical biological, biochemical, and cellular analysis techniques to analyze the regulation, intracellular function, and pharmacology of Raf kinases with the goal of providing new insight into how to more effectively target these enzymes as anti-cancer therapies.

PI_NAMEs: MALY, DUSTIN J (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Affect;Bar Codes;Biochemical;Biological;Biological Assay;cancer therapy;cell behavior;Cell Line;Cell membrane;Cell Physiology;Cells;Chemicals;chemoproteomics;Clinical;clinical development;clinically relevant;Complement;Complex;Data;Data Set;desensitization;dimer;Enzymes;Eukaryota;Event;experimental study;Family member;Genetic Transcription;Goals;Guanosine Triphosphate Phosphohydrolases;Heterogeneity;inhibitor;insight;Malignant Neoplasms;Mammalian Cell;MAP Kinase Gene;Maps;Measures;Mediating;MEKs;member;Methodology;Methods;Molecular;Molecular Conformation;mutant;Mutate;mutation screening;Nucleic Acids;Oncogenic;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phosphotransferases;Play;Proliferating;Property;Protein Isoforms;Proteins;Protomer;Raf Kinase Inhibitor;raf Kinases;Ras/Raf;recruit;Regulation;Resistance;Ribonucleoproteins;RNA;Role;self assembly;Serine;Signal Pathway;Signal Transduction;Site;small molecule;Structure;Techniques;Testing;therapeutic target;therapeutically effective;Threonine;tool;ubiquitin-protein ligase;Variant;variant of unknown significance;Work

PROJECT_TITLE: Chemical biological analysis of RAF Kinases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-K (02)]


PHR: Project Narrative INSPIRE will leverage deep expertise and resources in dissemination and implementation research and participatory approaches that center on advanced methods and modeling, and capacity support, while nurturing community engagement and dissemination practices. By harnessing the strengths and assets within the PATC3H-IN, findings will improve health outcomes of AYA at risk or living with HIV, by identifying novel insights on how to adapt, scale-up and sustain HIV research for AYA. A project of this scale has the potential to shift the paradigm on how dissemination and implementation science research is conducted for AYA in settings traditionally under-represented in research.

PI_NAMEs: GENG, ELVIN H.;IWELUNMOR, JULIET  (contact);TUCKER, JOSEPH DAVID

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: Adolescent;Adolescent and Young Adult;adolescent health outcomes;Adoption;advanced analytics;Affect;AIDS prevention;analytical method;Clinical Research;Collaborations;Communication;Communities;community engaged approach;community engagement;Comprehensive Health Care;Consultations;Continuity of Patient Care;cost;Country;crowdsourcing;design;Disparate;Dissemination and Implementation;dissemination science;Ensure;Epidemic;Evaluation;evidence base;experimental study;Family member;Friends;Future;Geography;Goals;Grant;Heterogeneity;HIV;implementation research;implementation science;improved;Income;Individual;Inequity;innovation;insight;interest;International;Intervention;Intervention Trial;Kenya;Knowledge;Learning;lens;low and middle-income countries;Malawi;member;Methodology;Methods;Mission;Modeling;Nigeria;novel;Output;peer;Policy Maker;Population;population health;Population Heterogeneity;preference;Prevention;Research;Research Personnel;Resource-limited setting;Resources;response;Risk;Rural;scale up;Science;Scientist;shift work;South Africa;statistics;stem;synergism;System;Tanzania;Testing;Thinking;Training;translational impact;Translational Research;Vision;Work;working group;Writing;Zambia

PROJECT_TITLE: Innovative Network on the Science and Practice of Implementation, Research, and Engagement Center (INSPIRE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-B (50)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Pediatric;Pediatric - AIDS;Prevention

PI_NAMEs: GENG, ELVIN H. (contact)

PROJECT_TERMS: Acceleration;Address;Adolescent;Adolescent and Young Adult;Area;Attitude;care providers;career;Clinical Research;Communities;community engagement;Complex;Consultations;cost;cost effectiveness;Country;Data Analyses;Dedications;design;Disparate;Economics;Effectiveness;effectiveness evaluation;Electronic Medical Records and Genomics Network;Ensure;Epidemic;epidemiological model;Evaluation;Evidence based intervention;experience;experimental study;Family member;flexibility;Friends;Goals;Heterogeneity;HIV;Human;implementation science;improved;Individual;innovation;insight;interest;Intervention;Intervention Studies;Interview;Joints;meetings;member;Methodology;Methods;model building;Modeling;network models;open source;Patients;Persons;Phase;Play;Policies;Policy Maker;Population;Positioning Attribute;preference;Process;Qualitative Methods;Race;Reading;Request for Applications;Research;Research Design;Research Personnel;Resources;Risk;Role;Running;scale up;Science;Services;shape analysis;Shapes;Site;Statistical Methods;success;Surveys;synergism;System;Techniques;Time;timeline;Training;Translational Research;usability;user-friendly;Work;working group

PROJECT_TITLE: Advanced Methods & Modeling (AMMC)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Pediatric;Pediatric - AIDS;Prevention

PI_NAMEs: TUCKER, JOSEPH DAVID (contact)

PROJECT_TERMS: Acceleration;Address;Adolescent and Young Adult;Adoption;Benchmarking;care providers;Case Study;Collaborations;combat;Communities;community engaged approach;community engagement;Community Outreach;community research;Consensus;Consultations;Country;Creativeness;crowdsourcing;Decision Making;Development;digital;dissemination strategy;Education and Outreach;Epidemic;evidence base;Family member;Friends;Goals;guidebooks;Guidelines;HIV;Individual;Infrastructure;innovation;Instagram;interest;Intervention;Leadership;low and middle-income countries;Measures;member;Methods;Mission;Modeling;Monitor;Nigerian;outreach;Play;Policies;Policy Maker;Problem Solving;Process;programs;Research;research data dissemination;Research Personnel;Research Priority;Resources;Risk;Role;scale up;Science;service programs;Services;Site;social media;Strategic Planning;success;symposium;Target Populations;Time;Training;Training Activity;translational impact;Translational Research;Translations;Work;Youth

PROJECT_TITLE: Community Engagement & Dissemination (CEDC)


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Pediatric;Pediatric - AIDS;Social Determinants of Health

PI_NAMEs: IWELUNMOR, JULIET  (contact)

PROJECT_TERMS: Acceleration;Address;Adolescent;Adolescent and Young Adult;Affect;Area;Benchmarking;career;career development;Clinical Research;Collaborations;Communities;community engaged research;community engagement;community organizations;Comprehensive Health Care;Continuity of Patient Care;cost;Country;course implementation;Creativeness;Data;design;Dissemination and Implementation;dissemination science;Ensure;Epidemic;Equity;Evaluation;evidence base;Evidence based intervention;experience;Fostering;Foundations;Funding;Goals;Government;Grant;hackathon;health equity;HIV;Hour;implementation research;implementation science;implementation strategy;improved;Income;infancy;innovation;interest;Intervention;Lead;Leadership;Learning;low and middle-income countries;meetings;member;Methods;Modeling;Participant;Persons;Policy Maker;Population;preference;Prevention;Program Evaluation;programs;prototype;Public Health;recruit;Research;research and development;Research Personnel;research study;Resource-limited setting;response;scale up;Science;Societies;success;synergism;Training;translational impact;Translational Research;Work;Writing

PROJECT_TITLE: Implementation Science Capacity Supporting (IS-CSC)


NIH_SPENDING_CATS: Kidney Disease

PHR: PROJECT NARRATIVE Acute kidney injury (AKI) is a common clinical condition with high mortality rates, long-term impact on patients’ health and quality of life, and no definitive treatments that mitigate the injury or accelerate recovery. This study aims to advance our understanding of the fundamental pathogenesis of ischemia-reperfusion AKI, as well as elucidate the novel role of Interferon-Stimulated Gene 15 as a host protective factor regulating cell death and inflammation during AKI. This knowledge could then be used to develop novel therapeutic targets and innovative strategies to treat AKI, with the potential to impact millions of lives.

PI_NAMEs: CARPENTER, JESSICA MARIE (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acceleration;Acute Kidney Tubular Necrosis;Acute Renal Failure with Renal Papillary Necrosis;Affect;Apoptosis;Attention;Bilateral;Biochemical;Bioinformatics;Biology;Blood Volume;Caspase Inhibitor;Cell Death;cell type;Cells;Cellular Infiltrate;chemokine;Chronic Kidney Failure;Clinical;Co-Immunoprecipitations;Collaborations;Complex;Critical Illness;Cycloheximide;cytokine;Data;Death Rate;Development;Disease;educational atmosphere;End stage renal failure;Environment;Epithelial Cells;Epithelium;experience;experimental study;Fellowship;Functional disorder;Genes;Genomics;Health;Hospitalization;Immune response;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;Inflammatory Response;Injury;Injury to Kidney;Innate Immune Response;innovation;Institution;Integration Host Factors;Intensive Care;Interferons;Ischemia;Kidney;kidney cell;Kidney Diseases;Knowledge;Literature;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Myocardial Infarction;new therapeutic target;novel;Outcome;Pathogenesis;Pathway interactions;Patients;Pattern;Persons;Phenotype;Phosphotransferases;Physicians;Play;Population;Positioning Attribute;Predisposition;Production;protective factors;protein function;Proteins;Quality of life;Recovery;Regulation;renal damage;renal ischemia;repaired;Reperfusion Injury;Reperfusion Therapy;Research;Research Personnel;response;response to injury;RIPK3 gene;Role;Scientist;Sepsis;Shock;Signal Transduction;single nucleus RNA-sequencing;skills;Stimulus;Supportive care;Testing;Therapeutic;therapeutically effective;tissue injury;TNF gene;Training;Tubular formation;Ubiquitin Like Proteins;Up-Regulation;Viral Proteins;Work

PROJECT_TITLE: Interferon-Stimulated Gene 15 as a Novel Regulator of Cell Death DuringAcute Kidney Injury

STUDY_SECTION_NAME: Fellowships in Kidney, Urology, and Hematology[DDK-G]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Heart Disease;Mental Health;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Stressful life events can increase risk of cardiovascular disease. This study examines neural and behavioral measures of negative affect and cognitive reappraisal as modifiers of subclinical CVD biomarkers (e.g., carotid artery intima media thickness, systemic inflammation, metabolic syndrome) following exposure to negative life events. By identifying biopsychosocial patterns that may buffer or facilitate early CVD pathophysiology, this study will help clarify individual differences in the relationship between stressful life events and cardiovascular disease and inform research on CVD prevention.

PI_NAMEs: WU-CHUNG, E. LYDIA (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Acceleration;Adult;Affect;Affective;Age;Amygdaloid structure;Anterior;Area;atherogenesis;Atherosclerosis;atherosclerosis risk;Behavior;behavior measurement;Behavioral;biobehavior;Biological Markers;biopsychosocial;Blood Pressure;Body mass index;Brain;brain based;Brain Stem;Buffers;cardiometabolic risk;cardioprotection;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career;Carotid Arteries;Carotid Atherosclerotic Disease;carotid intima-media thickness;Cessation of life;Chronic;Chronic stress;cingulate cortex;Clinical;cognitive reappraisal;comorbidity;Computer Models;Data;data de-identification;design;Development;Disease;Disease Progression;disorder risk;Dorsal;emotion regulation;Emotional;emotional stimulus;Emotions;environmental stressor;Event;experience;Exposure to;Fellowship;follow-up;Functional disorder;functional MRI scan;Glucose;Grant;Health;high risk;Hippocampus;Hypothalamic structure;Immune;Immunoassay;indexing;Individual;Individual Differences;Inflammation;Inflammatory;Insula of Reil;Insulin Resistance;Interleukin-6;intimal medial thickening;Knowledge;Life;Life Stress;Link;Lipoproteins;Longitudinal cohort;Measures;Medial;Metabolic;Metabolic syndrome;Moods;Morbidity - disease rate;mortality;multimodality;National Heart, Lung, and Blood Institute;negative affect;neural;neuroimaging;Neurosciences;Neurosecretory Systems;Participant;Pathogenesis;Pathway interactions;Patient Self-Report;Pattern;Peripheral;Personal Satisfaction;Persons;Physiology;pre-clinical;predictive modeling;Prefrontal Cortex;Prevention;programs;prospective;protective effect;Psychoneuroimmunology;psychosocial;Questionnaires;Regulation;Research;Research Design;resilience;response;Risk;Risk Factors;socioeconomics;statistics;Stress;Stressful Event;stressor;System;systemic inflammatory response;Testing;Training;trait;Triglycerides;Ultrasonography;Venous blood sampling;Visit;waist circumference;Woman;Writing

PROJECT_TITLE: Understanding the link between stressful life events and cardiovascular disease risk: A health neuroscience approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Parkinson’s Disease is the second-most common neurodegenerative disorder, yet there are currently no available disease-modifying therapies. In this proposal, we will investigate the potential roles of Rab27a and Rab27b in the endocytosis and autophagic-lysosomal clearance of the key pathogenic protein alpha-synuclein. This work will increase our understanding of the mechanisms of asyn propagation and accumulation, identifying potential therapeutic targets for slowing disease progression and alleviating clinical symptoms.

PI_NAMEs: SCHOLZ, KASANDRA J (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Adult;Age;alpha synuclein;Area;Bilateral;Biological Assay;Brain;career;Cell Culture Techniques;Cell Line;Cell model;Cells;Clinical;Communication;Corpus striatum structure;Data;Data Analyses;Defect;Dementia with Lewy Bodies;Development;Disease;Disease Progression;Dopaminergic Cell;Economic Burden;Endocytosis;experience;Exposure to;forging;Foundations;Future;Goals;Grant;Human;Image;In Vitro;in vivo;Injections;knock-down;Knockout Mice;Knowledge;Lewy Body Dementia;Ligation;Literature;Lysosomes;Manuscripts;Mediating;Mediator;member;Modeling;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurons;Neurosciences;Neurosciences Research;new therapeutic target;novel therapeutics;overexpression;paracrine;Parkinson Disease;Parkinson's Dementia;Pathogenicity;Pathology;Pathway interactions;Patients;Prevalence;prevent;Process;Protein Family;Protein Isoforms;Proteins;rab GTP-Binding Proteins;Research;Research Technics;responsible research conduct;Role;Science;Scientist;skill acquisition;skills;social;Solid;Structure of beta Cell of islet;Substantia nigra structure;Symptoms;synuclein;synucleinopathy;Temporal Lobe;Testing;therapeutic target;Tissue Harvesting;Toxic effect;trafficking;Training;Translational Research;uptake;Work;Writing

PROJECT_TITLE: Role of Rab27 Isoforms on Alpha-Synuclein Endocytosis and Clearance


NIH_SPENDING_CATS: Aging;Arthritis;Genetics;Osteoarthritis

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: NARRATIVE Osteoarthritis (OA) is a highly prevalent disease characterized by chronic joint inflammation and pain, constituting a leading cause of disability in the US; yet there is not a single FDA-approved treatment to halt OA. We plan to investigate the genetic basis and functional significance of the heterogeneity of mast cells, a type of immune cells that may uniquely contribute to the inflammatory milieu in OA. This work will provide critical insights into OA-specific inflammation and inspire the design of a new line of strategy as disease-modifying therapy for OA.

PI_NAMEs: ZENG, LI  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Ablation;Affect;Aging;Angiogenic Factor;Anterior Cruciate Ligament;Anti-Inflammatory Agents;Arthralgia;Arthritis;Cartilage;Cell surface;Cell Surface Proteins;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chondrocytes;Chronic;Chronic Disease;Chymase;Clinical Trials;Conditioned Culture Media;cytokine;Cytoplasmic Granules;Data;Degenerative polyarthritis;design;disability;Disease;Enzymes;FDA approved;Female;Future;gain of function;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic information;Grant;Heterogeneity;Histamine;Histologic;Homeostasis;Human;IL3 Gene;Immune;Immunocompromised Host;In Vitro;in vivo;indexing;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;Injury;insight;Investigation;joint destruction;joint inflammation;joint injury;Joints;liquid chromatography mass spectrometry;loss of function;mast cell;Methods;mouse model;Mus;Nature;novel;Obesity;Pain;Pathogenesis;Pathology;Peptide Hydrolases;Persons;Pharmaceutical Preparations;Phenotype;Production;Property;Proteins;Proteome;Proteomics;Regulation;Reporting;Research;Research Personnel;Reverse Transcriptase Polymerase Chain Reaction;Rheumatoid Arthritis;Risk Factors;Role;Severities;sex;single-cell RNA sequencing;Skin;Societies;Sorting;Subgroup;Synovial Membrane;Technology;Testing;Time;Tissues;transcriptome;Tryptase;VEGFA gene;Weight-Bearing state;Work

PROJECT_TITLE: Impact of mast cell heterogeneity on Osteoarthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (03)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: Project Narrative We are studying an inherited specific antibody deficiency (SAD), in which all affected individuals have a tandem duplication intersecting the immunoglobulin heavy chain (IgH) locus. One duplicated gene, JAG2, is overexpressed exclusively in patient B cells, which we hypothesize is due to enhancer hijacking of the IgH locus and causing SAD in these patients. Enhancer hijacking is commonly documented in malignancies but has yet to be identified in inborn errors of immunity (IEI), and work from this project has the potential to unveil a novel genetic mechanism of IEI.

PI_NAMEs: TOBIN, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Affect;Age;Agonist;Antigens;ATAC-seq;Autoimmunity;autosome;B cell differentiation;B Cell Proliferation;B-Lymphocyte Subsets;B-Lymphocytes;Bacteremia;CD19 gene;Cell Differentiation process;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Child;Chromatin;Chromosome 14;Clinical;clinical diagnosis;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;congenital immunodeficiency;Development;Diagnosis;differentiation in vitro;Disease;Enhancers;exome sequencing;experimental study;Family;Family member;Fathers;Female;Flow Cytometry;Gene Duplication;Gene Expression Regulation;Genes;Genetic;genetic approach;Genetic Diseases;genetic disorder diagnosis;genome sequencing;Goals;Heterozygote;Hi-C;high dimensionality;High Prevalence;Human;human disease;humoral immunity deficiency;IGH@ gene cluster;Immune;Immune response;Immune system;Immune System Diseases;Immunoglobulin Class Switching;Immunoglobulins;improved;In Vitro;Individual;Infection;Inheritance Patterns;Inherited;interleukin-21;Interleukin-4;Laboratories;Lentivirus;Ligands;lymphoblastoid cell line;male;Malignant Neoplasms;Measles;Measures;Memory;Memory B-Lymphocyte;Modeling;Molecular;molecular targeted therapies;mouse model;Mutation;notch protein;novel;Organoids;overexpression;Pathogenesis;Patient Care;Patients;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;Plasmablast;Pneumococcal vaccine;Polysaccharides;Predisposition;Proliferating;promoter;protein function;Recurrence;Regulation;Reporting;Research;response;Rest;Role;Serum;Siblings;Signs and Symptoms;Single Nucleotide Polymorphism;Specific antibody deficiency;Stimulus;Streptococcus pneumoniae;Techniques;Testing;TNFSF5 gene;Tonsil;Transcript;Transcriptional Regulation;transcriptome sequencing;Up-Regulation;Vaccines;Variant;whole genome;Work

PROJECT_TITLE: Enhancer Hijacking of the IgH Locus as a Novel Genetic Mechanism of Inborn Errors of Immunity


NIH_SPENDING_CATS: Genetics

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Evolutionary constraints determine how organisms can adapt to multiple selection pressures and therefore influence many evolutionary processes, including those with human health relevance like drug resistance evolution, pathogen host range evolution, and cancer evolution. However, we still do not well understand the determinants of such constraints and how constraints arising from different processes change the dynamics of evolution. The proposed research will expand upon a high- throughput yeast barcoding experimental evolution system to dissect the constraints underpinning metabolic specialization and understand how they change over longer time scales, thereby answering fundamental questions about the nature of evolutionary constraint and generating quantitative insights into their dynamics.

PI_NAMEs: VISHER, ELISA  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Examining the conditionality and time dynamics of evolutionary constraint in yeast

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence

PHR: PROJECT NARRATIVE Drug discovery has a high rate of failure which affects the number of diseases that are treated. The failure rate is due to the partial knowledge of the functional protein pathways that create the healthy and disease phenotype. Identifying protein pathways is currently a slow, incremental process focusing on a few well-studied proteins, and so this work aims to explore the entire proteome to predict disease mechanisms that can be targeted by drug therapies.

PI_NAMEs: NAYAR, GOWRI  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Address;Affect;Algorithms;Amino Acid Sequence;Attention;Benchmarking;Biological;Biological Markers;Characteristics;Classification;Clinical Trials;Collaborations;Complex;Computational algorithm;Computing Methodologies;Data;Data Analyses;Data Set;Data Sources;deep neural network;design;Disease;disease phenotype;drug candidate;drug development;drug discovery;Drug Targeting;Educational process of instructing;Equilibrium;experimental study;Failure;FDA approved;fitness;Genes;Goals;Grouping;Health;heterogenous data;heuristics;Human;improved;Individual;Knock-out;Knowledge;large language model;Learning;learning algorithm;Link;Maps;Measures;Mentorship;Methods;Molecular;molecular phenotype;Mutation;Network-based;new therapeutic target;next generation sequencing;novel;overexpression;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Policies;pre-clinical;prediction algorithm;Process;Protein Databases;protein protein interaction;Protein Region;Proteins;Proteome;Proteomics;Psychological reinforcement;Psychopathology;Publishing;Recording of previous events;Reporting;Research;Research Personnel;Resources;response;shot learning;Source;Specificity;Structure;symposium;targeted treatment;Technology;Time;Tissues;Training;training data;transcriptome sequencing;Universities;Variant;vector;Work

PROJECT_TITLE: Exploring Understudied Proteins to Predict Novel Pathways and Associations to Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Bipolar cells are the first interneurons of the retina primarily responsible for sampling photoreceptor input and distributing it into ON and OFF visual streams, yet new research suggests that each bipolar cell subtype collects and transforms different salient components of the visual scene (luminance, frequency, contrast, etc.) in different ways. This project will use super-resolution microscopy, Ca2+ imaging, electrophysiological techniques, and biophysical modeling to examine distinctive synaptic mechanisms in CBC2 Type 2 OFF cone bipolar cells and determine their unique contribution to overall retinal function. This knowledge is vital for producing a more comprehensive understanding of retinal physiology and developing new solutions to address human visual dysfunctions, and is a central goal in vision research.

PI_NAMEs: WAKEHAM, COLIN M (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Amacrine Cells;AMPA Receptors;Anatomy;appendage;biophysical model;biophysical properties;Biophysics;Buffers;career;cell type;Cells;Chlorides;combat;Computer Models;Cone;Coupling;Dedications;Dendrites;Dependence;Development;effective therapy;Egtazic Acid;Electric Capacitance;Electrophysiology (science);Exocytosis;experimental study;Feedback;Fluorescence Microscopy;Frequencies;Glutamate Receptor;Glutamate Transporter;Glutamates;Goals;Human;Image;Immunofluorescence Microscopy;Interneurons;Knowledge;Learning;Light;Lobular;luminance;Measurement;Mediating;Mediator;Membrane;Mentorship;Morphology;Mus;nano;Neurons;novel;Output;patch clamp;Perforation;Periodicals;Pharmacology;Photoreceptors;Physiological;Physiology;Play;Positioning Attribute;postsynaptic;Presynaptic Terminals;Probability;Process;Property;Publishing;receptor;Recovery;Regulation;Research;response;Retina;Retinal Cone;Retinal Diseases;Retinal Ganglion Cells;ribbon synapse;Rod;Role;Sampling;segregation;Shapes;sight restoration;Signal Pathway;Signal Transduction;Steam;Stream;Strychnine;superresolution microscopy;Synapses;Synaptic Transmission;Synaptic Vesicles;System;Technical Expertise;Techniques;teleost;Time;Training;ultra high resolution;Vesicle;vesicular release;Vision research;Visual;visual dysfunction;visual information;Visual Pathways;visual processing;Visual System;voltage;voltage clamp

PROJECT_TITLE: Characterizing the Unique Biophysical Properties of the CBC2 OFF Cone Bipolar Cell

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Immunotherapy has been largely ineffective in pancreatic cancer, with surprisingly little research on the roles of natural killer (NK) cells in this disease. I propose to improve pancreatic cancer immunotherapy by promoting NK cell accumulation and co-localization with tumor cells, either by using drugs to alter the pancreatic cancer tumor microenvironment or by creating site-specific chemokine gradients that attract NK cells to promote anti-tumor effects. Successful completion of this project will fill current gaps in scientific knowledge and potentially identify new immunotherapy strategies that can prolong life for pancreatic cancer patients.

PI_NAMEs: LEKAN, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: 3-Dimensional;Activated Natural Killer Cell;anti-PD1 antibodies;Antibodies;antitumor effect;Antitumor Response;Biological Assay;cancer cell;Cancer cell line;cancer immunotherapy;CCL3 gene;cell motility;cell type;Cells;chemokine;Chemotactic Factors;Clinical;CXCL10 gene;CXCL11 gene;CXCL9 gene;Cytolysis;Cytometry;cytotoxic;Data;Data Set;Dipeptidyl Peptidases;Disease;Drug usage;Enzymes;Epithelial Cells;fibroblast-activating factor;Fibroblasts;Fibrosis;functional status;Human;IL18 gene;Image;imaging platform;imaging system;Immune;immune activation;Immune response;Immunologics;Immunosuppression;Immunotherapy;Implant;improved;In Vitro;in vitro Assay;in vivo;Individual;Infiltration;inhibitor;Innate Immune System;Knowledge;Laboratories;Leucocytic infiltrate;Life;Lymphocyte;Malignant Epithelial Cell;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Memory;migration;Mining;Modeling;multiplexed imaging;Mus;Natural Killer Cells;Natural Selections;neoplastic cell;novel;novel strategies;Outcome;overexpression;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;programmed cell death protein 1;Protease Inhibitor;recruit;Refractory;Research;Role;Site;spheroids;Survival Rate;T-Lymphocyte;Testing;Therapeutic;trafficking;tumor;tumor microenvironment;tumor progression;Up-Regulation

PROJECT_TITLE: Promoting Activated Natural Killer (NK) Cell Accumulation in Pancreatic Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (22)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: The knowledge gained from this investigation can aid in the identification of Veterans at greatest risk for poor longer-term mental health and suicidality and inform interventions aimed at interrupting trajectories that put Veterans at risk for these outcomes. Findings from Aim 1 can inform the implementation of more targeted approaches to identifying and intervening with Veterans at risk for experiencing poor longer-term mental health and suicidality. Findings from Aim 2 can be used to ensure that interventions are tailored to the unique needs of women Veterans. Findings from Aim 3 can inform efforts to bolster Veterans’ resilience to post-military stressors.

PI_NAMEs: VOGT-RYAN, DAWNE SUZANNE (contact)

PROJECT_TERMS: Address;Anxiety;Attention;Chronic;cohort;Collaborations;COVID-19;COVID-19 impact;Data;design;Development;Early Intervention;Ensure;experience;Feeling suicidal;follow up assessment;Gambling;Goals;Health;high risk;high risk drinking;implementation intervention;improved;innovation;insight;Interruption;Intervention;Investigation;Knowledge;Life;Link;Literature;Mediator;men;Mental Depression;Mental Health;Methodology;Military Personnel;military veteran;Modeling;novel;Outcome;outcome prediction;Play;population based;Post-Traumatic Stress Disorders;prevent;preventive intervention;Recontacts;Reporting;Research;resilience;Risk;Role;Sampling;SARS-CoV-2 exposure;secondary analysis;Secure;Services;Sex Differences;social relationships;Social support;Stress;stressor;Subgroup;suicidal;Suicide;Suicide attempt;Suicide prevention;Surveys;therapy development;Time;Veterans;Vocation;Woman;Work

PROJECT_TITLE: Implications of Veterans' Initial Reintegration Experiences for their Longer-Term Mental Health and Suicidality: Identifying Veterans who Would Benefit from Early Intervention

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Pulmonary viral infections and inflammation are leading causes of morbidity and mortality worldwide. A coordinated multi-immunity arm approach is critical to respond to damage and infection, and also to resolve inflammation and repair tissue. The cellular interactions between Type 1 lymphocytes (T1L) and Type 2 lymphocytes (T2L) and dynamic cross-regulation between T1L and T2L that comprise lung resident immune system are poorly understood. This work will investigate the cross-regulation of type 1 and type 2 immune responses in pulmonary viral infection, which would inform the design of new precision therapeutics to ameliorate pulmonary inflammation in humans.

PI_NAMEs: CARYOTAKIS, SOFIA  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute;Allergic;Allergic Disease;Allergic inflammation;Alveolar;Amphiregulin;apoptosis in lymphocytes;Apoptotic;arm;Asthma;asthma exacerbation;Bacteria;Body Weight;Body Weight decreased;Cell Death;Cell Death Induction;Cessation of life;Chronic;Complex;Confocal Microscopy;counterregulation;COVID-19 pandemic;cytokine;Data;design;Development;Disease;Distal;Fibroblasts;Foundations;global health;Goals;Helper-Inducer T-Lymphocyte;Human;Hypersensitivity;Immune;Immune response;Immune system;Immunity;Impairment;Individual;Induction of Apoptosis;Infection;Inflammation;Influenza A virus;insight;Interferon alpha;Interferon Type II;Interferons;Interleukin-13;Interleukin-5;Listeria monocytogenes;Lung;Lung Diseases;Lung infections;lung injury;Lymphocyte;lymphocyte effector molecules;Lymphocyte Function;Lymphocyte Subset;lymphocyte trafficking;Lymphoid Cell;Mediating;Modeling;Morbidity - disease rate;mortality;Mus;novel;Outcome;pathogen;Patients;Precision therapeutics;Predisposition;Production;Proliferating;pulmonary function;Pulmonary Inflammation;Recovery;Regulation;Repression;respiratory;response;Rest;Role;SARS-CoV-2 infection;seasonal influenza;Severities;Signal Induction;Signal Transduction;Source;Structure of parenchyma of lung;Testing;Three-Dimensional Imaging;three-dimensional modeling;tissue repair;Tissues;trafficking;transcriptomics;Viral;Viral Respiratory Tract Infection;Virus Diseases;Weight Gain;Work

PROJECT_TITLE: Type 1-2 immune cross-regulation in the lung

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE In the brain, inhibitory signals are critical for maintaining neural balance and preventing neurological and cognitive disorders. The retinal circuitry, with its well-organized architecture, diverse inhibitory cell types, and experimental accessibility, is an ideal system for investigating inhibitory signals and their role in information processing. Gaining a better understanding of how inhibitory signals in the retina contribute to visual processing holds the potential not only for enhancing tools to treat vision-related diseases but also for addressing conditions like epilepsy and anxiety linked to impaired inhibitory function.

PI_NAMEs: RUDZITE, ANDRA MARIJA (contact)

PROJECT_TERMS: Acute;Address;Affect;Amacrine Cells;Anxiety;Architecture;Behavior;Brain;cell type;Cells;Code;Cognition Disorders;Complex;Data;Dependovirus;Disease;Epilepsy;Equilibrium;Excision;Excitatory Synapse;experimental study;Feedback;gamma-Aminobutyric Acid;Genetic;Genetic Techniques;Goals;horizontal cell;Impairment;Individual;information processing;innovation;Interneurons;Kinetics;Light;Link;Mathematics;Measures;Mediating;Morphology;multi-electrode arrays;Nervous System Disorder;neural;Neurons;Neurosciences;Noise;novel;Optic Nerve;Outcome;Output;parallel processing;Pathway interactions;Pattern;Perception;Peripheral;Pharmaceutical Preparations;Pharmacology;Photoreceptors;Population;postsynaptic;prevent;Process;Property;Rattus;receptive field;receptor;response;Retina;Retinal Ganglion Cells;Role;Shapes;Signal Pathway;Signal Transduction;Source;spatiotemporal;Specificity;Stimulus;Structure;Synapses;System;Testing;Time;tool;transmission process;Vision;Visual;Visual Fields;visual information;visual processing;visual stimulus;Work

PROJECT_TITLE: Dissecting inhibitory mechanisms and their contribution to information processing in retinal ganglion cells.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anorexia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Pain Research;Serious Mental Illness

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The ability to learn how to avoid harm is critical for health and survival, yet excessive avoidance learning can lead to chronic maladaptive avoidance or compulsive behaviors. This study will evaluate avoidance learning, along with corresponding brain function and symptom expression, in anorexia nervosa and bulimia nervosa to reveal how altered decision-making and learning contribute to disordered eating. Knowledge gained will improve etiological models, identify novel therapeutic targets, and advance innovative treatment development for these often chronic, and sometimes deadly disorders.

PI_NAMEs: WIERENGA, CHRISTINA E (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Adult;Age;Amygdaloid structure;Anorexia Nervosa;Anxiety;anxious;Architecture;avoidance behavior;Avoidance Learning;Behavior;Behavioral;Binge Eating;binge type behavior;blood oxygenation level dependent response;Brain;Bulimia;Chronic;Clinical;Complex;Compulsive Behavior;Computer Models;conditioned fear;Corpus striatum structure;Dangerousness;Data;Decision Making;Desire for food;Development;Diagnostic;dietary restriction;Disease;Dorsal;Eating Behavior;Eating Disorders;effective intervention;effective therapy;Etiology;excessive exercise;Expectancy;falls;food avoidance;Foundations;Functional Magnetic Resonance Imaging;Future;Gambling;Harm Reduction;Health;Heterogeneity;improved;Individual;innovation;Insula of Reil;interest;Knowledge;Learning;Learning Disorders;learning strategy;maladaptive behavior;Medical;Mental disorders;Methodology;Modeling;neural;Neurobiology;new therapeutic target;novel;Operant Conditioning;Outcome;Pain;pain outcome;Participant;prevent;Process;Punishment;purge;purging behavior;response;Rewards;Signal Transduction;symptomatology;Symptoms;Testing;therapeutic target;therapy development;trait;Vomiting;Weight Gain;Woman

PROJECT_TITLE: Avoidance-driven Decision Making and Learning in Anorexia Nervosa and Bulimia Nervosa

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Digestive Diseases;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Women's Health Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Vocal communication deficits in Parkinson disease (PD) are common, debilitating, and appear decades prior to diagnosis; yet, their pathologic mechanisms are poorly understood. The proposed work will use a genetic rat model of PD to assess how vocal (dys)function and pathology manifest in the prodromal stage of disease. The goal of this work is to elucidate the earliest signs of vocal breakdown and associated neural pathology, which is foundational to advance PD diagnosis and treatment.

PI_NAMEs: KRASKO, MARYANN N (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustics;Address;Age;alpha synuclein;autosome;Behavior;behavior measurement;Behavioral;behavioral study;Biological Assay;Brain;Brain region;Brain Stem;career;Cell Nucleus;Characteristics;Clinical;clinically relevant;Communication;Constipation;Data;Data Set;Deglutition;Diagnosis;Disease;disease diagnosis;Dopamine;dorsal motor nucleus;early onset;Endopeptidase K;Environment;Enzyme-Linked Immunosorbent Assay;Esophageal motility disorders;Faculty;Fellowship;Female;Functional disorder;Future;Gait abnormality;gastrointestinal;gastrointestinal function;Gastrointestinal Physiology;Genetic;Genetic Models;Goals;Human;Immunohistochemistry;innovation;insight;Intestinal Motility;Knock-out;Knowledge;Limb structure;male;mathematical model;Measures;Mediating;Mentorship;Microscopy;mitochondrial dysfunction;Modeling;Motor;motor behavior;motor deficit;Mutation;Nervous System;neural;novel;nucleus ambiguus;Operative Surgical Procedures;Oropharyngeal;Oropharyngeal Dysphagia;Parkinson Disease;Pathologic;Pathology;Pattern;pharmacologic;Phosphorylation;PINK1 gene;Positioning Attribute;Postdoctoral Fellow;preclinical study;Predisposition;Process;Proteins;Quality of life;Rattus;Research;Research Design;Resistance;sex;Sex Differences;Signs and Symptoms;sporadic Parkinson's Disease;Substantia nigra structure;System;tenure track;Time;Tissues;tool;Training;translational genetics;Translational Research;Vagus nerve structure;vocalization;Voice;Work

PROJECT_TITLE: Vocal dysfunction and vagally mediated brainstem pathology in prodromal Parkinson disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (35)]


NIH_SPENDING_CATS: Cardiovascular

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative We are studying a key metabolic signaling molecule, AMPK, and its critical function in cardiovascular health and disease such as facilitating blood pressure maintenance through its interaction with the protein ACE2. While previous work identified that AMPK stabilizes ACE2 to offer cardiovascular benefits, our understanding of where and how this interaction occurs is limited. The work proposed here should lead to a better understanding of AMPK/ACE2 interactions to improve our understanding of blood pressure regulation and dysregulation, which affects millions of adults worldwide every year.

PI_NAMEs: LYONS, ANNE  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 2'-adenylic acid;ACE2;Adenosine Monophosphate;Adult;Affect;Angiotensins;Antibodies;Biochemical;Biological Assay;Biological Availability;Biosensor;Blood Pressure;blood pressure regulation;Blood Vessels;Ca(2+)-Calmodulin Dependent Protein Kinase;Cardiovascular Agents;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Cell membrane;Cells;Cellular Assay;Clinical;Data;Disease;drug development;drug efficacy;Electron Microscopy;Endoplasmic Reticulum;Endothelial Cells;Endothelium;Enzyme-Linked Immunosorbent Assay;experimental study;Fluorescence Microscopy;fluorophore;Fortification;Fractionation;Goals;Health;Homeostasis;Hypertension;Image;improved;Integral Membrane Protein;knock-down;Ligation;Light;Link;Location;Maintenance;Mediating;Membrane;Metabolic;Molecular;Molecular Chaperones;Monitor;Nitric Oxide;novel;Pathway interactions;Peptide Signal Sequences;Peptides;Phosphorylation;Phosphotransferases;Plasma Enhancement;Protein Kinase;Proteins;ratiometric;receptor;Regulation;Reporter;Research;Role;Serine;Signal Transduction;Signaling Molecule;Site;spatiotemporal;Specificity;subcellular targeting;Testing;Therapeutic;tool;trafficking;upstream kinase;Work

PROJECT_TITLE: Illuminating ER Lumen AMPK Dynamics for Maintaining Vascular Homeostasis via ACE2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-B (20)]


NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Spiral ganglion neurons (SGNs) of the auditory system slowly die after loss of auditory receptors called inner ear hair cells. Loss of either SGNs or inner ear hair cells negatively impacts normal hearing and efficacy of cochlear implants. This proposal will elucidate the neuroimmune interactions that promote SGN degeneration after inner ear hair cell loss, providing a foundation for the development of therapeutics aimed at maintaining SGN survival, ultimately improving normal hearing and efficacy of cochlear implants.

PI_NAMEs: CARO, ADRIANNA  (contact)

PROJECT_TERMS: Ablation;Acoustics;Adaptive Immune System;Age;Aminoglycoside Antibiotics;Anti-Inflammatory Agents;Auditory;Auditory system;B-Lymphocytes;Brain;CD19 gene;CD4 Positive T Lymphocytes;cell type;Cells;Cessation of life;chemokine;Cochlea;Cochlear Implants;Consensus;cytokine;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;deaf;deafening;Development;Electric Stimulation;Environment;experimental study;Foundations;Future;Gene Expression;Gene Expression Profiling;Genes;Hair Cells;hearing impairment;Immune;Immune response;Immunohistochemistry;improved;Inflammatory;Inner Hair Cells;Investigation;Kanamycin;KLRB1 gene;Knowledge;Labyrinth;Leukocytes;Literature;Lymphocyte;Lymphocyte Depletion;Macrophage;Measures;Mediating;Modeling;Morphology;Natural Killer Cells;Neonatal;Nerve Degeneration;Neuroimmune;neuron loss;neuronal survival;Neurons;neuroprotection;neurotoxic;normal hearing;Nude Rats;ototoxicity;Phagocytosis;Population;prevent;PTPRC gene;Rat Strains;Rattus;receptor;recruit;Reporting;Role;Sensorineural Hearing Loss;Sensory Hair;spiral ganglion;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Trauma

PROJECT_TITLE: Role of the Immune Response in Spiral Ganglion Neuron Death After Hair Cell Loss

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (13)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autoimmune Disease;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Patient Safety;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Alzheimer’s disease is a debilitating neurodegenerative condition with major contributions to risk and progression from the immune system; however, the relationship between early life immune conditions and future Alzheimer’s risk is not well understood at the individual phenotypic level. The proposed research will use real-world data from electronic health records from diverse individuals to quantify the clinical risk association between Alzheimer’s and autoimmune diseases over time, and it will include stratification by variables that are known to influence overall Alzheimer’s risk, including sex, race, and ethnicity. This work will increase patient and clinician understanding of modifiable Alzheimer’s risk factors and provide insight into the neuroimmune interface at the individual level, potentially leading to the development of novel immune-based therapies to lower Alzheimer’s risk.

PI_NAMEs: RAMEY, GRACE  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Affect;Age;Age of Onset;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Attenuated;Autoimmune;Autoimmune Diseases;Autoimmunity;Biological Markers;biological systems;Biometry;Brain;California;Caregivers;case control;Categories;Characteristics;Chronic;Clinical;Clinical Data;clinical risk;cohort;Cohort Studies;comparison control;complement system;Data;data warehouse;Databases;Dementia;Development;Diagnosis;Disease;Disease stratification;disorder subtype;drug repurposing;electronic health data;Electronic Health Record;electronic health record system;Endocrine;Ethnic Origin;Ethnic Population;Exhibits;Female;Future;Genetic Risk;health data;High Prevalence;Human;human disease;Immune;Immune system;Immune System Diseases;Immunotherapy;Incidence;Individual;Inequity;Inflammasome;Inflammation;Inflammatory;innovation;insight;Institution;Knowledge;Life;life span;Link;male;Molecular;Musculoskeletal;Nerve Degeneration;Neurocognitive Deficit;Neuroimmune;neuroinflammation;novel;Observational Study;Onset of illness;Pathogenesis;Pathologic;Pathway interactions;Patient Self-Report;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Population;Population Heterogeneity;population stratification;Positioning Attribute;Prevalence;protein aggregation;Proteins;Public Health;Quality of life;Race;racial population;Records;Research;Research Design;research study;Retrospective cohort study;Risk;Risk Assessment;Risk Estimate;Risk Factors;risk stratification;risk variant;Role;sex;Sex Differences;social factors;Social Interaction;Specificity;Stratification;symptomatology;Symptoms;System;tau Proteins;Testing;therapy development;Time;Universities;Validation;Variant;women versus men;Women's prevalence;Work

PROJECT_TITLE: Investigating clinical risk between autoimmunity and Alzheimer’s Disease in diverse human populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome

PHR: PROJECT NARRATIVE: The bacterial pathogen Salmonella Typhimurium must outcompete members of the microbiome to establish infection and cause disease. By understanding the mechanisms by which Salmonella (1) outcompetes specific members of the microbiome and (2) manipulates host immune responses to aid in this process, this work will uncover novel strategies to tip the scales of competition against Salmonella.

PI_NAMEs: NORTON, GRANT J (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Address;Anaerobic Bacteria;antagonist;Antibiotic Therapy;antimicrobial;Bacteria;bacterial metabolism;Colon;colonization resistance;commensal microbes;Communities;Data;Disease;Doctor of Philosophy;dysbiosis;enteric pathogen;Exhibits;fitness;Gastrointestinal tract structure;Goals;gut inflammation;gut microbiota;Homeostasis;Immune response;Immunity;In Vitro;in vivo;Individual;Infection;Inflammation;innovation;insight;Integration Host Factors;Intervention;intestinal homeostasis;Knowledge;Lectin;Mediating;member;Metabolic;metabolic profile;Metabolism;Metagenomics;metatranscriptomics;Microbe;microbial;microbiome components;microbiota;Modality;Modeling;mouse model;multiple omics;Mus;Natural Resistance;non-typhoidal Salmonella;novel;novel strategies;Outcome;Outcome Study;pathogen;Pathogenesis;pathogenic bacteria;prebiotics;preference;Probiotics;Process;Proliferating;Proteins;Regenerating islet derived protein 3-Gamma;Research;Resistance;Resource Allocation;Resources;response;ribosome profiling;Ribosomes;Role;Salmonella;Salmonella infections;Salmonella typhimurium;Shapes;stem;Symbiosis;targeted treatment;Testing;Therapeutic Intervention;Time;Training;Translations;Work

PROJECT_TITLE: Metatranslatomics enables functional profiling of microbial competition in the Salmonella-perturbed gut

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  The adult human cortex is organized along a fundamental principal hierarchy, and the extent to which the cortex functionally aligns with this hierarchy has been found to be associated with both development and diverse psychopathology. Using functional MRI data from large-scale datasets, this proposal will map the normative trajectory of the principal hierarchy across development and assess whether deviations from this trajectory are associated with transdiagnostic psychopathology and its genetic risk factors. Findings from the proposed study will advance our understanding of functional cortical development and lay a foundation for future endeavors to identify diagnostic markers, therapeutic targets, and interventional windows of opportunity for neuropsychiatric disorders.

PI_NAMEs: SUN, KEVIN  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Address;Adolescent;Adult;Age;autism spectrum disorder;Brain;Brain Mapping;career;Childhood;Clinical;Clinical Data;clinical diagnostics;clinical training;Cognition;cognitive development;cohort;comorbidity;connectome;Data Set;Development;Developmental Process;Diagnostic;diagnostic biomarker;Disease;Educational workshop;Ensure;Feasibility Studies;Fellowship;Foundations;Functional Magnetic Resonance Imaging;Funding;Future;Gene Expression;Genetic;Genetic Risk;genetic risk factor;genetic variant;genome wide association study;Genomics;Goals;Heritability;heritability pattern;Human;Image;indexing;Individual Differences;insight;inter-individual variation;Intervention;large scale data;lens;life span;Major Depressive Disorder;Maps;Measures;Mental disorders;Mentorship;Modeling;Molecular;myelination;Nature;neuroimaging;neuropsychiatric disorder;Neurosciences;novel;Outcome;Pathway interactions;Perception;Phenotype;Philadelphia;Physicians;polygenic risk score;Population;preservation;Process;programs;Properdin;psychiatric symptom;psychogenetics;Psychopathology;Research;Risk;Role;Sampling;Schizophrenia;Scientist;segregation;Signs and Symptoms;symposium;Symptoms;Synapses;synaptic pruning;Testing;therapeutic target;Training;Variant;Work

PROJECT_TITLE: Mapping the functional organization of the cortex across development: The principal hierarchy and transdiagnostic psychopathology risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Pediatric;Rare Diseases

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRITIVE Cornelia de Lange Syndrome (CdLS) and Coffin-Siris Syndrome (CSS) are clinically similar, multi-system genetic disorders caused by mutations in the cohesin and SWI/SNF protein complexes, respectively. We identified a SWI/SNF component, SMARCE1, as a regulator of cohesin activity and chromatin folding suggesting that cohesin dysfunction underlies an unknown shared pathophysiology between CdLS and CSS. Elucidating the role of SWI/SNF and SMARCE1 with respect to cohesin-mediated chromatin folding and gene expression will be paramount in understanding whether shared cohesin dysfunction leading to a similar signature of gene misregulation could serve as either a biomarker or future therapeutic target across both CdLS and CSS patients.

PI_NAMEs: WAI, MAY  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: 3-Dimensional;Acute;Agonist;Architecture;Biological Markers;Biology;Bruck-de Lange syndrome;Cell Line;Cells;Chromatin;Chromatin Loop;Chromatin Remodeling Factor;Chromatin Structure;Classification;Clinic;Clinical;Coffin-Siris Syndrome;cohesin;comparative;Complex;congenital heart abnormality;craniofacial;Craniofacial Abnormalities;Data;Data Set;Dependence;Development;developmental disease;differential expression;Disease;DNA Binding;Drosophila snf protein;Epigenetic Process;Etiology;experimental study;Face;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Diseases;genetic signature;Genome;genome wide screen;genome-wide;genomic data;genotyped patients;Goals;Health;Heart Abnormalities;Human;Image;In Situ Hybridization;In Vitro;in vivo Model;inhibitor;innovation;insight;Intellectual functioning disability;Knowledge;Label;Link;lymphoblastoid cell line;malformation;Mediating;Modeling;Molecular;Molecular Biology;Molecular Conformation;Mutation;novel;Organ;Pathogenesis;Patients;Pediatric Hospitals;Pennsylvania;Phenotype;Play;proband;Process;programs;protein complex;Regulation;Role;Severity of illness;Shapes;SMARCE1 gene;Specificity;Structure;SWI/SNF Family Complex;Syndrome;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Transcriptional Regulation;transcriptomics;Work

PROJECT_TITLE: Investigating SMARCE1 in Regulating Cohesin Activity, Chromatin Folding, and Gene Expression