NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Liver Disease;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Our general goal is to identify specific 3’tsRNAs that have therapeutic potential for treating human disease. We will do this using gene transfer and oligonucleotide delivery strategies in various model systems.

PI_NAMEs: KAY, MARK A (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Amendment;Animal Model;Animals;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;antitumor effect;Apoptosis;Biogenesis;Bioinformatics;Biological;Biological Models;Biological Process;Cell Proliferation;Cells;Complement;Data;Defect;Disease;Dose;Effectiveness;Excision;Gene Expression Regulation;gene therapy;Gene Transfer;Goals;guided inquiry;Health;Homeostasis;Human;human disease;improved;Induction of Apoptosis;insight;Journals;Learning;Left;Leucine;Liver;Liver neoplasms;Liver Regeneration;Malignant neoplasm of liver;Malignant Neoplasms;Medicine;Messenger RNA;Modeling;Molecular;molecular sequence database;mouse model;Mus;Nature;New England;Nomenclature;oligonucleotide delivery;Paper;Pathologic;Patients;Phenotype;Porifera;pre-clinical;Primary carcinoma of the liver cells;Production;Property;Protein Biosynthesis;Proteins;Recombinant adeno-associated virus (rAAV);regenerative;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RNA;RNA, Ribosomal, 18S;Role;screening;Small RNA;Technology;Therapeutic;Time;tissue regeneration;Tissues;Transfer RNA;Translations;tumor;Tumor-Derived;Untranslated RNA;vector;Work;Xenograft procedure

PROJECT_TITLE: 3' tsRNAs: biologic function and pre-clinical targeting for treating human disease


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Kidney Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

ORG_CITY: HEREDIA

ORG_COUNTRY: COSTA RICA

ORG_FIPS: CS

ORG_NAME: UNIVERSIDAD NACIONAL, COSTA RICA

PHR: PROJECT NARRATIVE Chronic kidney disease of unknown origin (CKDu) has taken a terrible toll on young working families living in rural areas of Central America. This project aims to identify risk factors for CKDu and decline in kidney function in four Central American countries: Costa Rica, Panama, Nicaragua and Guatemala. We will assess work and environmental exposures, social determinants (e.g., vector-borne or zoonotic diseases; and exposure to toxins as possible causes. This work will be conducted though the SALTRA (Central American Program for Health, Work and Environment) network connecting locally-based universities, NGOs, governmental organizations, public health authorities and local healthcare workers.

PI_NAMEs: CROWE, JENNIFER  (contact);GONZALEZ-QUIROZ, MARVIN

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: acronyms;Acute Renal Failure with Renal Papillary Necrosis;agricultural activity;agricultural community;agricultural region;Agrochemicals;Area;authority;biobank;Biological Markers;Biopsy;Blood;case control;Case/Control Studies;Central America;Central American;Chronic Kidney Failure;Collaborations;Collection;Communities;Costa Rica;Country;Coupled;Data;Deposition;design;Detection;Disease;Disease Progression;DNA;DNA sequencing;Dryness;Electron Microscopy;Enrollment;Environment;Environmental and Occupational Exposure;Environmental Exposure;Epidemiology;Etiology;experience;Exposure to;Factor Analysis;Family;Fever;fighting;follow-up;Genetic;genetic risk assessment;genetic risk factor;Glomerular Filtration Rate;Guatemala;Health;Health Personnel;Healthcare Systems;Heat Stress;Heavy Metals;Histopathology;Immunoglobulin G;Immunoglobulin M;Incidence;Individual;Infectious Agent;Injury to Kidney;Institution;Kidney;kidney biopsy;Longitudinal cohort;Low Birth Weight Infant;Malnutrition;Manuals;Mass Spectrum Analysis;Measurement;Measures;member;Metals;Morphology;Natural History;Nicaragua;novel;novel marker;Panama;pathogen;Patients;population based;Poverty;programs;prospective;Proteinuria;Public Health;Renal function;Renal Tissue;Research;Rest;Risk;Risk Factors;Risk Marker;RNA;Role;Rural;rural area;Saccharum;Silicon Dioxide;Site;social determinants;Spanish;Specimen;Spottings;Tissues;Toxic Environmental Substances;Toxin;transcriptome sequencing;Tubular formation;United States National Institutes of Health;Universities;vector-borne;Visit;Work;working men;young adult;Zoonoses

PROJECT_TITLE: Exploring risk factors and predictors of endemic CKDu in agricultural regions of four Central America countries


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Drug overdose deaths have increased twofold in the past decade and are the leading cause of injury death in the U.S. Disparities in access to naloxone, an opioid overdose reversal agent, may be partially responsible for the growing disparities in opioid overdose deaths for American Indian/Alaska Natives and Blacks, whose overdose death rates now exceed those of non-Hispanic Whites. Our objective is to develop a novel, comprehensive place-based measure of naloxone availability and document disparities in naloxone availability so that naloxone-distributing entities can make data-informed decisions on how to increase equity in naloxone access to reduce racial disparities in opioid overdose deaths in North Carolina.

PI_NAMEs: CARPENTER, DELESHA MILLER (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: access disparities;Affect;Alaska Native;Alaska Native population;American Indians;Black Populations;Black race;Cessation of life;Communities;community organizations;Community Pharmacy;Community Surveys;community-level factor;cost;COVID-19 pandemic;Data;Data Collection;Death Rate;Development;Disparity;disparity reduction;Drug usage;Economics;Ensure;Environment;Equity;experience;Fentanyl;geographic disparity;Geographic Locations;Goals;Health;health literacy;Health Status;high risk;Individual;Infrastructure;Injecting drug user;Injury;insurance claims;Literature;Low income;Maps;Measurement;Measures;Mediating;Mental Health;Methods;multidisciplinary;Naloxone;naloxone dispensing;Needle-Exchange Programs;Neighborhoods;North Carolina;Not Hispanic or Latino;novel;Opioid;opioid mortality;opioid overdose;opioid use disorder;Overdose;overdose death;Overdose reversal;overdose risk;Pharmaceutical Preparations;Pharmacy facility;Policies;Population;prevent;Privatization;programs;racial disparity;Reporting;Risk;Rural Community;Rural Population;segregation;social;social factors;Social isolation;Source;substance use treatment;synthetic opioid;Time;tool;treatment services;tribal community;United States;Update;vision development;Visual;web site;Work

PROJECT_TITLE: Creating a novel place-based measure to explain racial disparities in naloxone access to reduce opioid overdose deaths

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Infectious Diseases;Kidney Disease;Organ Transplantation;Pediatric;Prevention;Transplantation;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Organ transplantation is a life saving therapy for pediatric patients with end stage renal disease, but all transplants eventually fail due to a process called chronic allograft rejection. In addition, opportunistic infections have emerged as a major cause of morbidity and mortality in pediatric kidney transplant recipients. In this proposal, we have assembled a consortium of experienced transplant centers to perform a clinical trial with potential to advance point-of-care, develop an understanding of pathogen-specific immune responses and promote long-term allograft survival.

PI_NAMEs: BRISCOE, DAVID M. (contact)

PROGRAM_OFFICER_NAME: HAYES, DEBORAH

PROJECT_TERMS: 2019-nCoV;Acute;Address;Adopted;Adult;age related;aged;allograft rejection;Allografting;Antibody Response;Antithymoglobulin;Area;arm;Binding;Biological Assay;Biological Markers;Biopsy;Caring;Cell Communication;Cells;Cessation of life;Child;Childhood;Chronic;Clinical;clinical center;Clinical Trials;clinically significant;Collaborations;Creatinine;Data;data registry;Databases;Development;Diagnostic;Donor person;Education;efficacy evaluation;End stage renal failure;Enrollment;Evaluation;experience;Exposure to;Failure;follow-up;Functional disorder;Future;Genes;genome-wide;Genomics;Genotype;Goals;graft function;Graft Survival;Helper-Inducer T-Lymphocyte;Hospitalization;Human Herpesvirus 4;Immune;Immune response;Immunity;Immunobiology;immunoregulation;Immunosuppression;improved;Infection;Infectious Agent;Inflammation;innovation;insight;Isoantibodies;isoimmunity;Kidney Transplantation;Knowledge;Laboratories;Life;Life Expectancy;Living Donors;Maintenance;Maintenance Therapy;Mediating;Memory B-Lymphocyte;Monitor;Morbidity - disease rate;mortality;mTOR Inhibitor;mycophenolate mofetil;Neoadjuvant Therapy;novel;novel therapeutics;novel virus;open label;Opportunistic Infections;Organ Transplantation;Outcome;pathogen;Patients;Pattern;pediatric patients;Performance;Pilot Projects;point of care;Population;post-transplant;prediction algorithm;preservation;prevent;primary endpoint;Process;Production;Proteins;Randomized;Regimen;Renal function;Research Personnel;response;Risk;Schools;seropositive;Signal Pathway;Sirolimus;Solid;standard of care;Survival Rate;T-Lymphocyte;Tacrolimus;Testing;Therapeutic Agents;Therapeutic immunosuppression;tool;transcriptomics;transplant centers;Transplant Recipients;Transplantation;Transplantation Immunology;treatment arm;treatment choice;two-arm trial;urinary;Urine;vaccine-induced antibodies;Vaccines;virtual;Virus;Virus Diseases

PROJECT_TITLE: Advancing Transplantation Outcomes in Children


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Stigma remains a fundamental barrier to the HIV response in the US and around the world reflected as a priority by both government agencies and community partners. However, stigma data remains underutilized and stigma programs achieve limited scale if implemented at all. We posit that the proposed research builds on solid scientific premise and holds tremendous promise to advance the response to stigma and improve the quality of life of people affected by stigma in the US and ultimately facilitate progress in meeting HIV testing, prevention, and treatment goals as described in the Ending the HIV Epidemic Initiative.

PI_NAMEs: BARAL, STEFAN DAVID (contact)

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Address;Affect;AIDS prevention;American;Area;Behavioral;Caring;Centers for Disease Control and Prevention (U.S.);cisgender;Collaborations;Communities;community partners;Competence;Complement;Consolidated Framework for Implementation Research;dashboard;Data;Data Scientist;data tools;data visualization;design;Development;Diagnosis;Diagnostic;dynamic system;Ensure;Epidemic;epidemic preparedness;epidemic response;Epidemiologist;Epidemiology;Evaluation;experience;Future;Goals;Government Agencies;Guidelines;Health;health disparity;HIV;human centered design;Human immunodeficiency virus test;implementation research;improved;Incidence;indexing;Internet;Intervention;Knowledge;Letters;mathematical model;Measurement;meetings;men;men who have sex with men;Mental Health;Modeling;Municipalities;network models;Output;personalized approach;Persons;Policies;Policy Maker;Population Heterogeneity;pre-exposure prophylaxis;Prevention;Process;programs;Qualitative Methods;Quality of life;Research;response;Risk;Sampling;social stigma;Solid;Strategic Planning;success;Surveys;systematic review;Testing;tool;transgender women;Translating;Treatment outcome;treatment response;United States;United States National Institutes of Health;Update;usability;Viral;Visualization;Visualization software;Work

PROJECT_TITLE: Integrating the Visualization and Use of Stigma Data to Maximize the Impact of the Ending the HIV Epidemic Initiative


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Mental Health;Neurosciences

ORG_CITY: BELLEFONTE

ORG_NAME: ACTUATED MEDICAL, INC.

ORG_STATE: PA

PHR: Project Narrative: Relevance – Penetrating electrode arrays can provide direct access to neural signals across the central and peripheral nervous system with high spatial resolution. Chronic electrode implants could revolutionize treatment for a range of medical conditions, including prosthetic motor control for amputees, and brain- machine interfacing for paraplegics. Unfortunately, device implantation causes an immune response that contributes to device failure over time. This project commercializes a device that uses acoustic fields to mitigate the immune response effects that cause electrodes to fail over time.

PI_NAMEs: MULVIHILL, MAUREEN L. (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: Acoustics;Amputees;Anti-Inflammatory Agents;Astrocytes;Blood - brain barrier anatomy;Brain;brain computer interface;BRAIN initiative;brain machine interface;Central Nervous System;Cerebrum;Chemicals;Chondroitin ABC Lyase;Chronic;Cicatrix;Clinical;clinical application;commercialization;cost;design;Detection;Development;Devices;Dexamethasone;Disease;Effectiveness;electric impedance;Electrodes;Electronics;Electrophysiology (science);Environment;Enzymes;Equilibrium;Equipment Malfunction;Exploratory/Developmental Grant;Failure;Feedback;Foreign Bodies;Future;glial activation;Goals;healing;Human;human model;Immune response;Immunity;Impairment;Implant;implantation;Implanted Electrodes;improved;Incidence;Individual;Inflammation;Inflammatory Response;Injury;innovation;interest;Laboratory Research;Life;Longevity;Marketing;Measurable;Mechanics;Medical;Microelectrodes;Microglia;miniaturize;Modeling;Monitor;Morphology;Motility;motor control;Nervous System Disorder;neural;neural implant;Neurodegenerative Disorders;neuromechanism;Neurons;Neurophysiology - biologic function;neuroprosthesis;neuroprotection;neurotransmission;neurotrophic factor;next generation;Noise;Oligodendroglia;Outcome;Paraplegia;Pathology;Pathway interactions;Penetration;Performance;Peripheral Nervous System;Phase;Physiologic pulse;Population;portability;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical study;prevent;Prosthesis;prototype;Rattus;Research;Research Personnel;Resolution;response;Risk;Rodent;side effect;Signal Transduction;Site;Small Business Innovation Research Grant;System;technological innovation;Technology;Temperature;Testing;Therapeutic;Thinness;Time;Tissues;tool;Transducers;Translating;Translations;ultrasound;verification and validation

PROJECT_TITLE: Development of an Acoustic Implant Protection System to Improve Performance and Longevity of Neural Interfaces


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE/PUBLIC HEALTH SIGNIFICANCE The proposed research is relevant to public health because it proposes new approaches to characterize and address some of the most challenging problems in dementia caregiving, clinical management, and research; building on philosophical frameworks, social sciences methods, and up-to- date neurocognitive findings. Patient values are central to several key bioethical constructs in dementia such as advance care planning, while the centrality of values to relationships means that alterations in the values of people with dementia or how they express their values can contribute to caregiver distress. A fuller understanding of these changes from the perspective of people with dementia and their caregivers will inform approaches to support autonomy and to counsel caregivers in their efforts to adapt to these changes.

PI_NAMEs: CHIONG, WINSTON  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Address;Advance Care Planning;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Attitude;Behavioral;Bioethics Consultants;Brain;Budgets;care preference;care recipients;Caregiver Burden;Caregivers;caregiving;caregiving outcomes;caregiving research;Caring;Clinical;clinical care;Clinical Management;Clinical Research;Cognitive;Communication;Communities;Conflict (Psychology);coping;Counseling;Data;Data Collection;Decision Making;decision research;Dementia;dementia care;Dementia caregivers;dementia caregiving;Discipline;Distress;end of life;Enteral Feeding;Ethics;experience;follow-up;Frontotemporal Dementia;impaired capacity;Impairment;Individual;innovation;insight;interdisciplinary collaboration;Intervention;Interview;Investigation;Judgment;Legal;Life Support Care;Link;Longitudinal Studies;Measures;Medical;Memory;Methods;Motivation;multidisciplinary;Nerve Degeneration;Neurobiology;Neurocognitive;Neurology;Neuropsychology;novel;novel strategies;Participant;Patients;Pattern;Perception;person centered;Personality;Persons;Philosophy;poor health outcome;preference;preservation;psychological outcomes;Public Health;Research;Research Personnel;response;Role;Self Care;Self-reflection;social;Social Psychology;Social Sciences;Syndrome;theories;Time;Uninsured Medical Expense;Work

PROJECT_TITLE: Personal Values in Dementia Experience, Caregiving, and Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative Alzheimer's disease (AD) is a heterogeneous, exhibits selective vulnerability (SV) of both cells, genes and networks, but their mechanistic underpinnings remain unclear. Here we use powerful mathematical modeling to gather evidence for or against various SV hypotheses on empirical mouse models and their tauopathy data.

PI_NAMEs: RAJ, ASHISH  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Address;adjudication;Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;animal data;Beds;Brain;brain cell;Brain region;Calcium;Cell model;cell type;Cells;Cellular Morphology;Code;comorbidity;connectome;Consumption;Data;Data Set;Deposition;Development;Diffusion;Disease;Drug Design;Electrophysiology (science);Exhibits;experimental study;Fiber;Functional disorder;Future;Gene Expression;Generations;Genes;Genetic;Glutamates;Head;hippocampal pyramidal neuron;Hippocampus;Human;human data;human model;in silico;Inflammatory;insight;Investigation;Kinetics;Laboratories;Location;locus ceruleus structure;Maps;mathematical model;Mathematics;Mediating;Microglia;Mitochondria;Modeling;Molecular;Molecular Profiling;Morphology;mouse model;Mus;Nerve Degeneration;network models;Network-based;neural correlate;neural network;Neural Pathways;Neuroglia;Neurons;neuropathology;Neurosciences;Neurotransmitters;novel;Oligodendroglia;pathogen;Pathology;Pathway interactions;pre-clinical;Predisposition;prion-like;Property;prospective;Prospective Studies;protein aggregation;protein misfolding;Proteins;proteostasis;Research;resilience;response;Sampling;single cell sequencing;Spatial Distribution;spatiotemporal;Statistical Models;Statistical Study;Stereotyping;stressor;Structure;support network;Susceptibility Gene;System;tau Proteins;Tauopathies;Technology;technology platform;Testing;Time;transcriptomics;Transgenic Mice;Translating;transmission process;TREM2 gene;Validation;web platform;Work

PROJECT_TITLE: Mathematical modeling of selective vulnerability of genes, cells and network in mouse tauopathy

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Worldwide, tuberculosis (TB) is the most common cause of death in patients with HIV, and the growing epidemic of drug-resistance threatens decades of gains in TB prevention and care. James Brust, M.D. is an accomplished clinician-scientist at Albert Einstein College of Medicine with a strong research program focusing on the interplay of drug-resistant TB and HIV in South Africa. This K24 proposal will support Dr. Brust to 1) expand his multidisciplinary research program into new areas, focusing on novel TB medications, and 2) develop a strong mentoring program for junior investigators in TB, HIV, and global health patient-oriented research at Einstein and at his international collaborating sites.

PI_NAMEs: BRUST, JAMES C M (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Alveolar Macrophages;Animals;Area;Award;Binding Proteins;Biological Assay;Blood Cells;career;Caring;Cause of Death;cell type;Clinical;Clinical Investigator;Clinical Pharmacology;Clinical Research;clinical training;Clinical Trials;Collaborations;college;Communicable Diseases;Companions;Data;design;Development;Disease;Doctor of Medicine;Dose;Drug Exposure;Drug Kinetics;Drug resistance;Drug resistance in tuberculosis;Early treatment;Effectiveness;Enrollment;Environment;Epidemic;Epidemiology;epidemiology study;extensive drug resistance;Extreme drug resistant tuberculosis;Fellowship;Funding;Future;genome sequencing;Genomics;global health;Goals;Half-Life;HIV;HIV/TB;Hour;Human;improved;Individual;innovation;Institution;Interdisciplinary Study;interest;Intermediate resistance;International;Interruption;Kinetics;Knowledge;Leprosy;Linezolid;Lung;Measurement;Measures;medical schools;Medicine;Mentors;Mentorship;Meta-Analysis;Microbiology;Mid-Career Clinical Scientist Award (K24);Modeling;mortality;multidisciplinary;Multidrug-Resistant Tuberculosis;Mycobacterium tuberculosis;next generation;novel;novel therapeutics;Participant;pathogen;patient oriented research;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacology;Physicians;Plasma;Population;Postdoctoral Fellow;pre-doctoral;premature;Prevention;programs;Recommendation;Regimen;Research;Research Personnel;Resistance;Rifampicin resistance;Risk;Scientist;Site;skills;South Africa;Specialist;Structure;success;Survival Rate;tandem mass spectrometry;Therapeutic Index;Time;Training;translational study;Treatment outcome;Treatment Protocols;Tuberculosis;tuberculosis drugs;tuberculosis treatment;whole genome

PROJECT_TITLE: Mentoring of multidisciplinary global health research in tuberculosis and HIV

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE TDP is a common age-related pathology that is related to episodic memory loss and the Alzheimer’s clinical syndrome. It is pivotal to understand the morphologic and neurobehavioral phenotypes of TDP and whether it is modified by other pathologies - to guide studies of prevention and treatment.

PI_NAMEs: SCHNEIDER, JULIE A. (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Acceleration;Accounting;Adopted;Age;age related;Age related pathologies;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease related dementia;Anterior;Astrocytes;Autopsy;Awareness;Behavioral;biomarker validation;Blood Vessels;Brain;Cessation of life;Characteristics;Clinical;Cognitive;cognitive change;cohort;Communities;Data;decrease resilience;Dementia;Diagnosis;Enrollment;episodic memory impairment;ex vivo imaging;follow-up;Frontotemporal Lobar Degenerations;genetic variant;Gliosis;Goals;hippocampal sclerosis;Hippocampus;Image;Impaired cognition;Impairment;in vivo;in vivo imaging;Knowledge;limbic-predominant age-related TDP-43 encephalopathy;Link;literacy;Magnetic Resonance Imaging;Measures;Mediating;Memory;Memory Loss;Microglia;Morphology;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;neurobehavior;neurobehavioral;Neurodegenerative Disorders;Neuroglia;neuron loss;Neurons;neuropathology;Nomenclature;normal aging;Older Population;Pathologic;Pathology;Pattern;Persons;Phenotype;Prevention;protein TDP-43;Public Health;Research;Resources;Risk;Risk Factors;Role;Scanning;shape analysis;Shapes;symposium;Symptoms;Syndrome;Testing;tool;Translating

PROJECT_TITLE: Characterizing TDP-43 related hippocampal degeneration and memory loss in aging


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: This Training Program in Academic Endocrinology assembles a group of outstanding clinical and basic scientists to oversee the training of fellows with an interest in understanding the mechanism and regulation of hormone effects and how they are disrupted to produce clinical disorders. The core goal of this Training Program is to train scientists and physician-scientists in diverse aspects of the field of endocrinology, with an overarching emphasis on translational research. Fellows will be trained in fundamental research techniques in order to contribute to the understanding and treatment of major endocrine disorders, such as obesity, diabetes, and osteoporosis.

PI_NAMEs: KAISER, URSULA B. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Endocrinology;Grant;Training

PROJECT_TITLE: Training Grant in Academic Endocrinology

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dietary Supplements;Kidney Disease;Nutrition;Patient Safety;Prevention

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: PROJECT NARRATIVE  In this pilot clinical trial, we will recruit and randomize 120 patients with diabetes and chronic kidney disease (CKD/DM) stages 3 to 5 to a patient-centered and flexible Plant-Focused Nutrition in Diabetes (PLAFOND) diet with >2/3 plant-based sources, which will be compared with a standard-of-care CKD diet, which is usually a low-potassium and low-salt diet, over a 6-month period. Through this study, we will determine whether the plant-focused diet intervention is feasible for patient adherence, whether this diet is safe by avoiding malnutrition, frailty, and high potassium or glucose blood levels, and whether patient reported outcomes are favorably impacted.

PI_NAMEs: KALANTAR-ZADEH, KAMYAR  (contact);RHEE, CONNIE MEEYOUNG

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acids;Adherence;Adult;Affect;American;Animals;Anthropometry;base;Biochemical;Blood Glucose;Body Composition;California;Carbohydrates;Chronic Kidney Failure;Clinic;Clinical;Clinical Practice Guideline;Clinical Trials;Collection;Continuous Glucose Monitor;Data;design;diabetes management;Diabetes Mellitus;Dialysis procedure;diaries;Diet;Diet Modification;dietary;Dietary Intervention;Dietary Proteins;dietary restriction;Dietitian;Disease;Disease Progression;efficacy evaluation;Energy Intake;Exclusion;Expert Opinion;Fat-Restricted Diet;Feasibility Studies;feasibility testing;flexibility;follow-up;Foundations;frailty;Future;Glycosylated hemoglobin A;Guidelines;Hour;hyperkalemia;Hypertension;indexing;Intervention Studies;Kidney;Kidney Diseases;Kidney Failure;Lead;Malnutrition;Measurable;Measures;multi-site trial;Multicenter Trials;muscle strength;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;non-diabetic;nutrition;Nutritional;Nutritional status;Outcome;Patient Compliance;patient oriented;Patient Outcomes Assessments;patient safety;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physical Function;Physical Performance;Plant Sources;Plants;post gamma-globulins;Potassium;primary outcome;protein intake;Protein-Restricted Diet;Proteins;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Regimen;Renal function;Research;response;Risk;Role;Safety;safety and feasibility;satisfaction;secondary outcome;Serum;Sodium-Restricted Diet;Source;standard of care;Symptoms;Testing;Toxin;Transplantation;Universities;Uremia;Urine;Visit;wasting

PROJECT_TITLE: Plant-Focused Nutrition in Patients with Diabetes and Chronic Kidney Disease (PLAFOND Study): A Pilot/Feasibility Study

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: VERONA

ORG_NAME: MEDICAL CYBERWORLDS, INC.

ORG_STATE: WI

PHR: Project Narrative  Implicit Bias (IB) is a toxic and pervasive problem in healthcare that contributes to the preventable harm and death of Black patients. The work performed under this grant will produce the first-ever effective IB mitigation training system by virtue of its evidence-based focus on reducing providers’ nonverbal and paraverbal expressions of IB in race discordant medical encounters. It uses a new, distributable, AI-based Virtual Human (VH) simulation technology designed to heighten learners’ engagement and their awareness of IB, presenting them with detailed, personalized feedback and concrete strategies for mitigating IB by substituting positive nonverbal and paraverbal behaviors for negative behaviors and letting them reflect and practice their new skills over time.

PI_NAMEs: KRON, FREDERICK WILLIAM (contact);SCERBO, MARK WILLIAM

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Address;Adherence;Agreement;Attitude;Awareness;Behavior;black patient;Black race;brief intervention;Caring;Cessation of life;Code;Communication;communication behavior;Communities;Consultations;Data;design;Detection;Development;educational atmosphere;Educational Curriculum;Educational process of instructing;Emotional;Emotions;evidence base;experience;Eye;Face;Facial Expression;Faculty;Feedback;Frequencies;Funding;gaze;Gestures;Grant;Hand;Health;health equity;Healthcare;Impairment;Implicit Association Test;implicit bias;improved;individualized feedback;innovation;Internet;Learning;Licensing;Maintenance;Measures;Medical;medical schools;Medical Students;member;Methods;Modeling;non-verbal;Nonverbal Communication;Outcome;Patient Self-Report;Patients;Performance;Persons;Phase;Physicians;Pre-Post Tests;programs;prototype;Provider;Race;racial bias;Randomized;remediation;Research;Self-reflection;simulation;skill acquisition;skills;skills training;Small Business Innovation Research Grant;Societies;Speech;Standardization;standardize measure;Students;System;Technology;technology platform;Testing;Thinness;Time;Training;Trust;United States National Institutes of Health;verbal;Verbal Behavior;Virginia;virtual human;Work

PROJECT_TITLE: Modeling Professional Attitudes and Teaching Humanistic Communication to Remedy Implicit Bias and Promote Cultural Humility in Healthcare (MPathic-IBCH).


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: HOUSTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative This is a resubmission of a competing renewal application from 21 preceptors at Baylor College of Medicine, carrying 15 active qualifying NEI-R01 grants. This Training Program started in 1975 and has trained a large number of vision researchers who have made significant impacts to the field. The Program will continue to provide high-quality training for predoctoral students and postdoctoral fellows, and to equip them with comprehensive knowledge of the visual system and state-of-the-art experimental skills, enabling them to become successful researchers in the battle to fight blinding diseases.

PI_NAMEs: WU, SAMUEL M (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Research Training;vision science

PROJECT_TITLE: Research Training in Visual Sciences


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: QUEENS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ST. JOHN'S UNIVERSITY

PHR: Project Narrative A diverse array of chemicals and drugs including certain chemical warfare agents (sulfur mustard, lewisite), intravenous chemotherapy drugs (mechlorethamine-MEC, paclitaxel, liposomal doxorubicin), and environmental toxins (snake venom metalloproteinases and blister beetle cantharidin) can disrupt the dermal-epidermal junction (DEJ) and cause blistering, thereby placing a patient at risk for infection, loss of fluid and electrolyte homeostasis, and scarring; moreover, an effective antidote to blistering is still lacking and current medical treatments for blistering are limited to supportive therapy. The overall goal of the studies proposed here is to investigate the influence of rationally selected mast cell-derived mediators (histamine and tryptase), neutrophil-derived mediators (myeloperoxidase, MPO and matrix metalloproteinase 9, MMP-9) and keratinocyte-specific collagens (collagen IV, COL4 and collagen XVII, COL17) in the cutaneous response to DEJ disruption over time. The achievement of proposal objectives will more fully describe the complex response of skin to DEJ disruption and provide novel targets for the discovery of drugs capable of reducing blistering and restoring the DEJ.

PI_NAMEs: BILLACK, BLASE CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: 3-Dimensional;Achievement;Adverse effects;Affect;analog;animal care;Animals;Antidotes;Antihistamines;Antineoplastic Agents;Apoptosis;Appearance;Biological Assay;Biopsy;Bulla;CASP3 gene;CASP9 gene;Cell Culture Techniques;Cells;chemical reduction;Chemical Warfare Agents;Chemicals;chemotherapy;Chemotherapy-Oncologic Procedure;Cicatrix;Collagen;Collagen Type IV;Collagen Type XVII;Complement 3d;Complex;Computer software;Cream;Cutaneous;Data;Dermal;Dermis;Dimethyl Sulfoxide;DNA;Dose;Doxepin;Ear;ebselen;Edema;Electrolytes;Enzyme-Linked Immunosorbent Assay;Epidermis;Experimental Designs;experimental study;Exposure to;Extravasation;falls;Formalin;Foundations;Future;Gases;Gelatinase B;Goals;Harvest;Histamine;Histology;Homeostasis;Human;human tissue;Immunohistochemistry;In Vitro;in vivo;Incidence;infection risk;Infiltration;Inflammation;inhibitor;insight;Intravenous;keratinocyte;Kinetics;Knockout Mice;Learning;Leupeptins;lewisite;light microscopy;Lipid Peroxidation;Liposomal Doxorubicin;Liquid substance;Literature;mast cell;Mechlorethamine;Mediator;Medical;Metalloproteases;Modeling;Mus;Mustard Gas;neutrophil;Neutrophil Infiltration;novel;Nuclear;Order Coleoptera;Organoselenium Compounds;Paclitaxel;Pain;Paraffin Embedding;Patients;Peroxidases;Pharmaceutical Preparations;Poison;Predisposition;protein expression;Proteins;prototype;Reaction;Reporting;Research Proposals;response;response to injury;Role;Saline;Sampling;Serine Protease;skills;Skin;Skin Tissue;Snake Venoms;Students;Supportive care;Swelling;Techniques;Testing;Time;Tissue Embedding;Tissues;Topical application;Toxic effect;Toxic Environmental Substances;Tryptase;Western Blotting;Wild Type Mouse;Work;World War I

PROJECT_TITLE: Dermal-Epidermal Junction Disruptors: Toxicodynamic Mechanisms


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Mental Health;Neurosciences

PHR: Project Narrative The goal of predoctoral training in Neuroscience at UCSF is to guide and educate future researchers who will make fundamental creative discoveries, develop innovative research strategies and apply their skills and knowledge as a basis for ultimately protecting and improving health. This proposed training program will play an important role in educating students who will become our future biomedical researchers, and we promote the highest level of scientific integrity, public accountability, and social responsibility in the conduct of science. Having a well-trained cadre of researchers is the principal means that we, as a nation, have for understanding and treating illnesses and disabilities of our own and the world’s population.

PI_NAMEs: PLEASURE, SAMUEL JEREMY (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Neurobiology;pre-doctoral;Training

PROJECT_TITLE: Predoctoral Training in Neurobiology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Data Science;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative NACC (as U01 AG016976, at University of Washington — now seeking renewal as a U24) has been active since 1999, and has established a standardized, longitudinal clinical database of over 42,000 individuals (with neuropathology data on over 6,100), as well as cross-sectional, retrospective data on roughly 66,000 individuals seen at ADRCs between 1984 and 2005. NACC has made these data freely available to researchers worldwide, resulting in hundreds of publications. We will modernize and intensify our informatics approach, making data access and use more efficient; will grow communication and coordination capabilities with the ADRCs and collaborating NIA projects; will develop and apply big-data research tools for the field; and will provide competitive, peer-reviewed research support for several new investigators each year. Together with the field’s leaders, NACC will innovate, develop, and drive solutions to meet the changing needs of the field as well as the NIA ADRC program.

PI_NAMEs: BIBER, SARAH ;KUKULL, WALTER ANTHONY (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Acceleration;Achievement;Adoption;Age;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Applied Research;Area;Award;Big Data;Biological Markers;Biometry;career;clinical database;clinical examination;cohort;Collaborations;Communication;community center;Complex;Consultations;Contracts;Data;data access;Data Collection;Data Coordinating Center;data resource;Data Science;Data Set;data sharing;data storage site;data visualization;Databases;deep learning;Dementia;digital data;disease heterogeneity;e-science;Early Diagnosis;Enrollment;Environment;experience;Faculty;Funding;Future;Genetic;Genetic Diseases;Genomics;Goals;Heterogeneity;high standard;Image;improved;Individual;Informatics;Infrastructure;innovation;instrument;interest;interoperability;Leadership;Link;Medicine;meetings;Methodology;Methods;Mission;Modernization;neuroimaging;neuropathology;novel;Peer Review;Positioning Attribute;programs;Publications;Recording of previous events;repository;Research;Research Peer Review;Research Personnel;Research Support;Resources;Risk Factors;Sampling;Scanning;Scientist;Secure;Services;social media;Source;Specimen;Standardization;success;Techniques;Technology;Testing;Time;tool;translational health science;Translational Research;trend;Universities;Washington;web site

PROJECT_TITLE: National Alzheimer's Coordinating Center

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: EAST LANSING

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project narrative:  Biomarker discovery and diagnostic options for aggressive diseases such as cancer are imperative for better disease outcomes. A platform for rapidly discovering and evolving novel antibodies against glycoprotein cancer biomarkers will be developed. This new strategy can help significantly enhance the treatment options available to cancer patients.

PI_NAMEs: WOLDRING, DANIEL RAY (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Address;Affinity;Antibodies;Antibody Binding Sites;Antigens;Binding;Biological Markers;biomarker discovery;Breast;cancer biomarkers;cancer diagnosis;Cancer Patient;Carbohydrates;Carrier Proteins;Cell Separation;Cell surface;Cells;Clinical;clinical diagnosis;Complement-Dependent Cytotoxicity;Cytometry;design;Diagnostic;diagnostic tool;diagnostic value;Directed Molecular Evolution;Disease;Disease Outcome;empowerment;Engineering;Ensure;Enzymes;Epitope Mapping;Epitopes;Genomics;Glycopeptides;Glycoproteins;glycosylation;guided inquiry;Human;Imaging Device;Immune response;Immune system;Immunization;Immunoglobulin Somatic Hypermutation;improved;in vivo;Individual;interest;lead candidate;lead optimization;Libraries;Light;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Methodology;Methods;Molecular;molecular diagnostics;molecular imaging;Monoclonal Antibodies;Mus;neoplastic cell;novel;Ovarian;overexpression;Pancreas;Patient-Focused Outcomes;Pattern;Performance;Phylogenetic Analysis;Phylogeny;Polysaccharides;Protein Engineering;reconstruction;Sensitivity and Specificity;specific biomarkers;Specificity;Technology;Therapeutic;Therapeutic Monoclonal Antibodies;Time;Transgenic Mice;tumor;Tumor Cell Line;Tumor-Associated Carbohydrate Antigens;tumorigenesis;tumorigenic;vaccine development;Vaccines;Virus-like particle;Yeasts

PROJECT_TITLE: Rationally guided discovery platform for monoclonal antibodies against carbohydrate antigens using virus-like particle conjugate immunization and high throughput selection

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: DA

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: NARRATIVE The marmoset is an increasingly attractive non-human primate (NHP) model for understanding neurophysiology and there is a major interest in the field for using it to study neurodegenerative diseases, particularly to model the social and cognitive deficits that accompany them, which current animal models are unable to do. At present, no NHP models exist with trinucleotide repeat mutations at the endogenous allele as occurs in Huntington’s disease, in part because of limitations in the ability of the CRISPR/Cas9 system to introduce long stretches of DNA, as well as limitations in marmoset reproductive technologies. Therefore, we propose to establish a new strategy that utilizes the expanded developmental potential of ground-state pluripotent cells to generate animals that carry the precise human mutation through assistant reproductive technologies, which we believe will pave the road for transgenic marmoset models as superior preclinical models to transgenic mice.

PI_NAMEs: BRIVANLOU, ALI H (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Address;Affect;Alleles;Amino Acids;Animal Model;Animals;autosome;Behavior;Behavioral;behavioral phenotyping;behavioral response;Biology;Birth;blastocyst;Brain imaging;Breeding;Callithrix;Callithrix jacchus jacchus;Cell Line;Cells;Code;Cognitive deficits;cognitive process;Collaborations;Communities;Complex;Corpus striatum structure;CRISPR/Cas technology;Derivation procedure;Development;Developmental Biology;developmental disease;differentiation in vitro;differentiation protocol;Disease;disease model;Disease Progression;DNA;Embryo;embryonic stem cell;Exons;Experimental Genetics;Fertilization in Vitro;Frequencies;Functional disorder;Genes;Genome;Germ Cells;Germ Lines;Grant;Guide RNA;Heritability;homologous recombination;Human;Huntington Disease;Huntington gene;Imaging technology;In Vitro;insight;interest;Knock-in;Knock-out;knockout gene;Laboratories;Mental disorders;Modeling;Molecular;molecular phenotype;Monitor;Morula;Mus;mutant;Mutation;Nervous System;Nervous System Disorder;neural;neural circuit;Neurodegenerative Disorders;neurogenetics;Neuronal Differentiation;Neurons;neurophysiology;nonhuman primate;Onset of illness;optogenetics;Outcome;Performance;Peripheral;Phenotype;pluripotency;Pluripotent Stem Cells;polyglutamine neurodegenerative diseases;Population;post pregnancy;Pre-Clinical Model;prevent;Primate Diseases;Primates;Proteins;Protocols documentation;Reporter;Reporter Genes;Reproductive Technology;Research;Retrieval;Role;Serial Magnetic Resonance Imaging;single-cell RNA sequencing;Social Behavior;social deficits;stem cell biology;stem cells;Stretching;Surgical Replantation;System;Technology;transcriptomics;Transgenic Mice;Transgenic Organisms;transmission process;Trinucleotide Repeats;Universities;Visuospatial

PROJECT_TITLE: Correlating molecular behavioral phenotypes in a marmoset model of Huntingtons disease


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Sexually Transmitted Infections

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE Gonorrhea poses an immense threat to public health due to rising prevalence and the emergence of antibiotic- resistant bacteria, underscoring the importance of developing new strategies to prevent and treat gonococcal infections. N. gonorrhoeae's evasion of serum bactericidal activity is critical to its ability to infect humans, but while some advances have been made in defining the genetic basis of serum resistance, the description of the genes and pathways that contribute to serum resistance remains incomplete and their distribution in clinical isolates poorly understood. This proposal will address these gaps by applying a synergistic combination of approaches: identifying new serum resistance mutations through application of systematic phylogenetics and computational methods and experimental evolution and comprehensive characterization of their prevalence and distribution in a dataset of >16,000 clinical isolates.

PI_NAMEs: GRAD, YONATAN H (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Address;Alleles;Anabolism;Antibiotic Resistance;Bacterial Antibiotic Resistance;bactericide;Biological Assay;Biology;Clinical;Collection;Complement;Computing Methodologies;Data;Data Set;design;Diagnosis;diagnostic development;direct application;Disease;Epidemiology;Evaluation;Evolution;Face;Genes;Genetic;Genetic Determinism;genetic variant;Genetic Variation;Genome;genome wide association study;genomic locus;genomic tools;Genomics;Goals;Gonorrhea;high risk;Human;Immune;Immune response;Immune system;Immunotherapeutic agent;improved;In Vitro;Infection;infection rate;Invaded;Knowledge;Link;lipooligosaccharide;Literature;Mediating;Mutation;Neisseria gonorrhoeae;novel;Organism;Pathogenesis;pathogenic bacteria;Pathway interactions;Phenotype;Phylogenetic Analysis;Phylogeny;Physiology;Population;Predisposition;pressure;Prevalence;prevent;Prevention;Prevention strategy;Public Health;Reporting;Research Personnel;Resistance;resistance allele;resistance gene;resistance mutation;Role;Scientist;Serum;Sexually Transmitted Diseases;Shapes;Statistical Methods;Study of serum;surveillance strategy;Testing;Therapeutic;United States;vaccine evaluation;Variant;Work

PROJECT_TITLE: Genetic modulators of serum resistance in Neisseria gonorrhoeae

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Dietary Supplements;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE Alzheimer’s disease is one of the most common causes of dementia and a growing public health concern in the United States. Age is the greatest risk factor for AD, and dietary interventions that can promote health span and extend lifespan have significant potential to slow or prevent AD. This proposal will test the hypothesis that dietary interventions or pharmaceuticals which mimic the effects of these diets to reduce activity of the protein kinase mTORC1 and activate autophagy in the brain can slow or prevent the development and progression of AD.

PI_NAMEs: BABYGIRIJA, REJI  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Affect;Age;Aging;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapy;American;Amino Acids;Animal Model;Animals;APP-PS1;Autophagocytosis;Biology of Aging;Brain;Branched-Chain Amino Acids;Caloric Restriction;Calories;career;Catabolism;Cause of Death;Cell Physiology;Chronic Disease;Cognition;Cognitive deficits;Complex;Consumption;Cyclic AMP-Dependent Protein Kinases;Data;Defect;Dementia;Deposition;Development;Diet;dietary;dietary excess;Dietary Intervention;dietary restriction;Disease Progression;early onset;Eating;Economic Burden;effective therapy;Energy Intake;Essential Amino Acids;experimental study;extend lifespan;Faculty;Fasting;feeding;Fellowship;fly;Food;FRAP1 gene;geroprotector;Gliosis;Graduate Degree;Health;Healthcare Systems;healthspan;healthy aging;Hour;Human;human old age (65+);Impaired cognition;improved;Incidence;Individual;inhibition of autophagy;insight;interest;Intervention;Isoleucine;Keto Acids;laboratory experiment;Leucine;Life;life span;Link;Mediating;member;Mentorship;Metabolic;Metabolism;Modeling;Molecular;mouse model;multiple omics;Mus;Neurofibrillary Tangles;Nutrient;Oxidoreductase;Pathogenesis;Pathologic;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phosphotransferases;prevent;Protein Kinase;Protein-Restricted Diet;Proteins;Public Health;Regimen;Research;response;Risk Factors;Role;Signal Transduction;skills;small molecule inhibitor;Synapses;tau Proteins;tenure track;Testing;Training;United States;Valine;Wild Type Mouse;Work

PROJECT_TITLE: Dietary Interventions in Alzheimer’s Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F01A-V(20)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: The project is relevant to public health because it is expected to result in an innovative application of advanced MRI technologies for guiding bacterial cancer therapies. This proposed multimodal MRI approach can be used to pre-select treatable tumors prior to the treatment by assessing tumor hypoxia and monitor bacterial cancer treatment in a real-time and non-invasive manner, providing new utility for pursuing the optimal efficacy while maintaining safety. Successful completion of the proposed study will provide robust image guidance that can ultimately improve the success rate of bacterial cancer therapies for treating inoperable solid tumors, which is highly relevant to the part of NIH’s mission.

PI_NAMEs: BAI, RENYUAN ;LIU, GUANSHU  (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Acceleration;Address;Algorithms;Anaerobic Bacteria;Animal Model;Antibiotic Therapy;Area;Bacteria;Bacterial Infections;cancer therapy;Chemicals;Clinical;clinical investigation;Clinical Trials;Data;detection sensitivity;Development;Doxycycline;Equilibrium;feasibility testing;Gene Modified;Germination;Goals;Histology;Human;Hypoxia;Image;image guided;Imaging Device;Imaging technology;improved;Infection;innovation;Location;Magnetic Resonance Imaging;Measures;Medicine;Methods;microbial;microbial based therapy;Mission;Modeling;Monitor;mortality;multidisciplinary;multimodality;Mus;Neurofibrosarcoma;non-invasive imaging;Oncologist;Oxygen;Patient Recruitments;Patients;Pharmaceutical Preparations;Positron-Emission Tomography;Predictive Value;Proliferating;Protocols documentation;Public Health;Radiology Specialty;research clinical testing;Research Personnel;response;Safety;Sarcoma;Sepsis;Signs and Symptoms;Solid Neoplasm;Speed;Stratification;success;Surrogate Markers;Systemic infection;Technology;technology platform;Therapeutic;Therapeutic Effect;Time;TP53 gene;Transgenic Organisms;Translating;Translations;Treatment Efficacy;treatment planning;tumor;tumor hypoxia;United States National Institutes of Health;Vascularization

PROJECT_TITLE: Multimodal MRI for guiding bacterial cancer therapy

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The goals of this predoctoral T32 are: 1) to train the next generation of cardiovascular researchers for conducting impactful collaborative and translational research; and 2) to enhance the numbers of top quality researchers and leaders by providing training for the advancement of women to all trainees, improve the culture for women to succeed, and increase the retention of women in independent scientific careers.

PI_NAMEs: BIESIADECKI, BRANDON J;RAFAEL-FORTNEY, JILL A (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TITLE: Training to provide the knowledge, skills, and culture to the next generation of cardiovascular scientists

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: 7. PROJECT NARRATIVE The reliance on consumer choice and active coverage management in the Medicare program may place the nearly 6 million older adults living with Alzheimer’s and related dementias (ADRD) at increased risk of financial barriers to needed health services, substantial out-of- pocket health spending, and potentially worse health outcomes. This mixed-methods study will describe the Medicare choices of individuals with ADRD throughout the course of the disease, evaluate the impact of these choices on health and financial outcomes, and examine the role of family caregivers and baseline socioeconomic resources in mitigating potential adverse effects. Results from this study will inform policy makers about the implications of current program design on the equity of Medicare for individuals with ADRD and guide future policy interventions that can support this vulnerable population in managing their Medicare coverage.

PI_NAMEs: MCGARRY, BRIAN  (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Adverse effects;Affect;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Award;beneficiary;Budgets;career development;Caregiver support;Caregivers;Clinical;clinical care;cognitive ability;Cognitive aging;cognitive capacity;cognitive change;Cognitive deficits;cognitive disability;Complex;coping;Data;Decision Making;decision-making capacity;Dementia;design;Diagnosis;Disease;Drug Prescriptions;Ensure;Equity;experience;Family Caregiver;family caregiving;Family Research;Foundations;Future;Health;Health and Retirement Study;health care availability;health inequalities;Health Services;Health Services Accessibility;Health Services for the Aged;Health Services Needs;Health Services Research;Health Status;Household;Impaired cognition;Impairment;Individual;Institution;Interdisciplinary Study;Intervention;Interview;K-Series Research Career Programs;Lead;Leadership;Link;Measurement;Medicare;Medicare claim;Medicare Part C;Medicine;Mentors;Mentorship;Methods;mild cognitive impairment;multidisciplinary;older adult;Outcome;Personal Satisfaction;Policies;Policy Maker;poor health outcome;Population;Predisposition;Privatization;professor;programs;Psychologist;Qualitative Research;Quasi-experiment;Research;Research Methodology;Research Personnel;Resources;response;Risk;Role;Security;social;socioeconomics;Surveys;Testing;Time;Training;Uninsured Medical Expense;Universities;Vulnerable Populations

PROJECT_TITLE: The Impact of Alzheimer's Disease and Related Dementias on Older Adults' Medicare Coverage Choices, Financial Well-being, and Health

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Cervical cancer is a disease that predominantly affects women in low- and middle-income countries (LMICs), as these settings lack the personnel resources and infrastructure to implement the cervical cancer prevention strategies that have virtually eliminated cervical cancer in high income countries (HICs). Cervical cancer is a rapidly worsening public health crisis that requires immediate interventions to meet the World Health Organization’s (WHO) metrics to achieve elimination of cervical cancer in the next 100 years. The Pocket CARE algorithm developed and validated as part of this proposal will make possible a single-visit model for cervical cancer screening and treatment that will help meet the key WHO metrics for cervical cancer elimination.

PI_NAMEs: HUCHKO, MEGAN J.;ODHIAMBO, FRANCESCA AKOTH;RAMANUJAM, NIRMALA  (contact)

PROGRAM_OFFICER_NAME: SAHASRABUDDHE, VIKRANT V

PROJECT_TERMS: Acetic Acids;Address;Adopted;Affect;Algorithms;Ambulatory Care;Artificial Intelligence;Biopsy;burden of illness;Caring;Cause of Death;Cellular Phone;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervix Uteri;Cessation of life;Characteristics;Classification;clinic ready;Clinical;Clinical Research;clinical research site;Colposcopes;Colposcopy;comparative effectiveness;Computer software;contrast imaging;convolutional neural network;cost;Country;Coupled;Cytology;Data;Databases;Decision Aid;deep learning;deep learning algorithm;Development;Devices;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic strategy;Disease;Educational Status;Effectiveness;Ensure;Evaluation;experience;follow-up;Generations;global health;Goals;Guidelines;Health;Health care facility;Healthcare;Hemorrhage;HPV positive;HPV screening;HPV-High Risk;Human Papillomavirus;Human Resources;Image;impression;improved;Incidence;Income;Infertility;Infrastructure;innovation;Intervention;Kenya;Knowledge;Letters;Light;Location;low and middle-income countries;machine learning algorithm;Malignant neoplasm of cervix uteri;Medical Research;Methods;mHealth;Modeling;mortality;National Cancer Institute;overtreatment;Pathology;Performance;Physicians;Pilot Projects;Population;portability;Predictive Value;premalignant;Prevention strategy;Process;prospective;prospective test;prototype;Provider;Public Health;real world application;Recommendation;Research;Research Institute;Resolution;Resources;Retrieval;Risk;risk prediction model;risk stratification;ROC Curve;screening;Sensitivity and Specificity;Series;Site;Specificity;standard care;success;Technology;technology development;Testing;tool;Training;Triage;Validation;virtual;Visit;Visual;Woman;Women's mortality;women's treatment;Work;World Health Organization

PROJECT_TITLE: Development and Validation of an Artificial-Intelligence-enabled Portable Colposcopy Device for Optimizing Triage Alternatives for HPV-based Cervical Cancer Screening


NIH_SPENDING_CATS: Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Heart Disease;Hypertension;Obesity;Prevention;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This proposal is relevant to public health because it will be the pivotal trial to demonstrate the effectiveness of personal air cleaners (PACs) to reduce fine particulate air pollution <2.5 µM (PM2.5) and lower blood pressure, a novel intervention to reduce the cardiovascular effects of PM2.5 exposure. The proposed trial is relevant to the strategic visions of the NHLBI pertaining to hypertension-related cardiovascular disease, and air pollution inequity as an environmental determinant of cardiovascular health. .

PI_NAMEs: NEWMAN, JONATHAN D (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Address;Adherence;Adult;adult obesity;Age;air cleaner;Air Pollutants;Air Pollution;ambient air pollution;American;Attention;Autonomic Dysfunction;Biological;biological adaptation to stress;Blood;Blood Pressure;blood pressure elevation;blood pressure reduction;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cardiovascular health;Cessation of life;Clinical;Clinical Trials;clinically relevant;cohort;Cohort Studies;Communities;Consensus;cytokine;Data;design;Disparity;Dose;Double-Blind Method;Effectiveness;Ensure;Environment;Epidemic;experience;Exposure to;Face;fine particles;Fingers;Goals;Health;health inequalities;High Prevalence;high risk;Home;Hour;Housing;Humidity;Hypertension;hypertensive;Individual;Indoor Air Pollution;Inequity;Inflammatory;innovation;Interleukin-1 beta;Interleukin-6;Intervention;Knowledge;Link;Measurement;Measures;Mediating;Meta-Analysis;meter;Monitor;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;New York City;Non obese;non-smoker;novel;novel strategies;obese person;Obesity;Outcome;Particulate;Pathway interactions;patient response;Patients;Persons;Pharmaceutical Preparations;Physiological;Pollution;Population;Populations at Risk;portability;Predictive Factor;primary endpoint;Proteins;Public Health;Public Housing;Public Policy;Randomized;Research Personnel;Resources;response;Risk Factors;Seasons;secondary endpoint;sex;Specific qualifier value;Spottings;Strategic vision;success;systemic inflammatory response;Temperature;Testing;Time;treatment arm;Twin Multiple Birth;Urban Community;urban underserved;Vascular Diseases;Vulnerable Populations

PROJECT_TITLE: AirPressureNYC: Reducing AIR pollution to lower blood PRESSURE among New York City public housing residents

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Complementary and Integrative Health;Diabetes;Dietary Supplements;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Patient Safety;Precision Medicine;Prevention

ORG_CITY: WASHINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative About 6 million Americans suffer from heart failure and one third of the patients with heart failure die within a year of the diagnosis. While lower blood magnesium levels have been linked with the incident and outcomes of heart failure, it is unknown whether magnesium supplements (~$0.05 each pill) may lower that risk. We propose to interrogate national electronic health record data from Veterans Health Administration using novel pharmacoepidemiology methodology and develop explainable deep-learning models to help clinicians and patients make personalized decisions to maximize the health benefits of magnesium supplements.

PI_NAMEs: AHMED, ALI ;WU, WEN-CHIH ;ZENG, QING  (contact)

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: active comparator;Address;Adult;Adverse event;Affect;American;Atherosclerosis;Benefits and Risks;Blood;Blood Vessels;Calcium;Cardiac;Characteristics;Clinical;Clinical effectiveness;cohort;cost;Data;Databases;deep learning;deep learning model;design;Diabetes Mellitus;diabetes risk;Diagnosis;dietary;Dietary Magnesium;dietary supplements;Effectiveness;Electronic Health Record;Eligibility Determination;endothelial dysfunction;Enzymes;Equilibrium;follow-up;Functional disorder;Goals;Health;Health Benefit;Heart failure;high risk;Hospitalization;Human;Hypomagnesemia;Impairment;improved;improved outcome;Individual;individual patient;Inflammation;Insulin Resistance;insulin sensitivity;Intake;interest;Investigation;Knowledge;Laboratory Animals;Learning;Link;Long-Term Effects;Longterm Follow-up;Machine Learning;Magnesium;Magnesium Deficiency;Measures;Medical Records;Methodology;Mg supplementation;Minerals;Modality;Modeling;mortality;mortality risk;multiple chronic conditions;novel;Observational Study;Oral;Outcome;Pathway interactions;Patients;Pattern;personalized decision;Pharmacoepidemiology;phenotypic data;pill;Pilot Projects;Polypharmacy;Population;post-market;precision medicine;predictive modeling;prospective;Public Health;randomized controlled design;Randomized, Controlled Trials;Recommendation;Reporting;Risk;Risk Factors;risk prediction model;Risk Reduction;Safety;Sample Size;Serum;Structural Models;Supplementation;System;Techniques;Technology;Testing;therapeutic effectiveness;Time;tool;United States Department of Veterans Affairs;United States Food and Drug Administration;United States National Institutes of Health;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Magnesium supplement and vascular health: Machine learning from the longitudinal medical record

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Approximately 1 in 10,000 children are born blind or become blind early in life, often due to problems associated with prematurity or complications during birth. Here, we will examine the anatomical, functional and behavioral changes that occur following loss of vision at three important developmental stages. These data can direct therapeutic interventions (e.g. tactile training based behavior), and even allow predictions for behavioral outcomes following retinal implants or gene targeted therapies performed at different ages.

PI_NAMEs: KRUBITZER, LEAH ANN (contact)

PROJECT_TERMS: Acoustic Stimulation;Acute;Address;Adult;Affect;Age;Age of Onset;Anatomy;Animal Model;Animals;Area;area striata;Auditory;auditory processing;auditory stimulus;Axon;Behavior;behavior prediction;behavior test;Behavioral;behavioral outcome;Bilateral;Birth;blind;Blindness;Body part;Brain;Cannulas;Child;Complex;Data;Development;Didelphidae;Discrimination;Electrophysiology (science);Embryo;Environment;experimental study;extrastriate visual cortex;Eye;Failure;fluorophore;Forelimb;gene-targeted therapy;grasp;Impairment;Implant;in utero;Injections;kinematics;Laboratories;Life;Link;machine learning algorithm;Mammals;mature animal;Mediating;Microinjections;Modality;Monodelphis;Monodelphis Domestica;Movement;multimodality;Mus;Muscimol;Neocortex;Nervous System;neural;Neuroanatomy;Neurons;new growth;novel;Organ;Pathway interactions;Performance;premature;Property;response;Retina;retina implantation;Retinal Ganglion Cells;retinogeniculate;Sensory;sensory input;sensory system;Shapes;Skin;somatosensory;Somatosensory Cortex;Stimulus;Tactile;Task Performances;Texture;Thalamic Nuclei;Therapeutic Intervention;Time;Tracer;Training;Vibrissae;Vision;Visual;Walking

PROJECT_TITLE: Cross modal plasticity following loss of vision at different developmental stages:  Cortical function, connections and compensatory behavior

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Nonlipogenic ABCA1 inducers for ADRD Both Type 2 diabetes and Alzheimer's disease are serious and growing health crises that have several causative factors in common. We propose to design and develop new therapeutics that target these causative mechanisms and also address the major genetic risk factor for Alzheimer's disease.

PI_NAMEs: THATCHER, GREGORY R. J (contact)

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: ABCB1 gene;Acute;ADD-1 protein;Address;aging population;Agonist;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Animal Model;antagonist;Antiinflammatory Effect;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Astrocytoma;ATP binding cassette transporter 1;ATP-Binding Cassette Transporters;Attenuated;Behavioral;Binding;Biological Assay;Biological Availability;Biological Markers;Body Weight decreased;Brain;Cell Culture Techniques;Cell Line;Cells;chemoproteomics;Cholesterol;Chronic;Cognition;comorbidity;cytokine;Data;Dementia;dementia risk;Dependence;design;Development;Disease associated microglia;Dose;drug discovery;Dyslipidemias;familial Alzheimer disease;Fluorescence Resonance Energy Transfer;Future;gene product;Genes;genetic risk factor;Genotype;glucose metabolism;Health;HepG2;High Fat Diet;Human;Hypertriglyceridemia;Immunoassay;Impairment;improved;in silico;In Vitro;in vivo;Inflammation;Inflammatory;innovation;Insulin Resistance;insulin signaling;Knock-in Mouse;Lead;lead optimization;lipid biosynthesis;lipid metabolism;Lipids;Liver;Liver X Receptor;loss of function mutation;LXRalpha protein;Macrophage;Measures;meetings;Metabolic Diseases;metabolome;metabolomics;Modeling;mouse model;Mus;Mutation;neural;Neurons;neuropathology;Neutropenia;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Nuclear Receptors;Obesity;obesogenic;Oral;Oral Administration;Pathogenicity;Pathology;patient population;pharmacodynamic model;Pharmacodynamics;Pharmacology;Phenotype;PPAR gamma;Prevalence;Primary carcinoma of the liver cells;Primates;promoter;Reporter;Reporting;Research;resilience;Risk;Risk Factors;Safety;screening;Series;Steatohepatitis;tau Proteins;Testing;Triglycerides;Up-Regulation;Validation;Weight Gain

PROJECT_TITLE: Nonlipogenic ABCA1 inducers for ADRD


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE Results from the proposed work will have major implications for the neural basis and treatment of disorders of cognition, such as attention-deficit hyperactivity disorder (ADHD) which is one of the most common mental disorders affecting children, and which also afflicts adults. Thus the proposed research on the role the primate prefrontal and parietal cortex, and prefrontal dopamine, in attention and working-memory will have clear implications for mental health.

PI_NAMEs: MOORE, TIRIN  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Adult;Affect;Area;Attention;Attention deficit hyperactivity disorder;attentional control;Behavior;behavior influence;Behavioral;Brain;Child;Cognition Disorders;combat;contextual factors;density;Dopamine;Exhibits;experimental study;extrastriate;extrastriate visual cortex;Eye Movements;frontal eye fields;Funding;gaze;Goals;Image;innovation;lateral intraparietal area;Lead;luminance;Maintenance;Mediating;Mental disorders;Mental Health;Methods;Midbrain structure;Motivation;Motor;Movement;neural;neural circuit;neural correlate;neuromechanism;Neurons;neurophysiology;nonhuman primate;oculomotor;Parietal;Parietal Lobe;Perception;Prefrontal Cortex;Preparation;Primates;public health relevance;Research;retinal imaging;Role;Saccades;selective attention;Sensory;Shapes;Short-Term Memory;Signal Transduction;Source;Stimulus;Structure;superior colliculus Corpora quadrigemina;System;Testing;tool;virtual;Vision;Visual;Visual attention;visual cognition;visual control;Visual Cortex;visual information;Visual Perception;visual processing;visual stimulus;Visual System;Work

PROJECT_TITLE: Interaction of Visual and Oculomotor Signals in Cortex

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative/Relevance to PUBLIC HEALTH: Old age can lead to a variety of changes and declines in memory, but healthy older adults may be able to selectively remember important information in certain situations. The proposed research examines how stress and rushing can influence how older adults remember important information, how older adults can selectively forget outdated information related to gains and losses, and how older adults may be susceptible to scams and financial fraud that focus on gains and rewards. We introduce ways that older adults can successfully identify features of scams such that selective memory can be used to prevent scams and financial fraud, and the findings have the potential to enhance the quality of life and independence of older adults by providing new ways to help older adults remember important information.

PI_NAMEs: CASTEL, ALAN D (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Aging;aging population;Anxiety;Area;Arousal;Attention;Awareness;Behavioral;Child;COVID-19;directed forgetting;Education;experience;Fees;forgetting;Fraud;Friends;Fright;Goals;Health;healthy aging;human old age (65+);Hypersensitivity;Impairment;improved;Income;innovation;Learning;Loneliness;Measures;member;Memory;Memory impairment;Memory Loss;memory process;metacognition;Motivation;novel;older adult;Outcome;Performance;Persons;practical application;Predisposition;prevent;Price;Process;programs;Public Health;Quality of life;Research;Retirement;reward processing;Rewards;Risk;Social Distance;Spouses;Stress;Testing;Theoretical model;Time;Training;Update;Victimization;Work;young adult

PROJECT_TITLE: Goals and Motivation to Remember Important Information in Old Age

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Despite evidence of efficacy, Integrative Pain Management is not reaching low-income populations at greatest risk for chronic pain and related opioid overdose. This research and training plan will inform implementation of Integrative Pain Management interventions at scale, improving access to communities most at-risk.

PI_NAMEs: ROTH, ISABEL  (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Academy;Address;Adherence;Administrator;Adoption;Adult;American;American College of Physicians;Analgesics;Applications Grants;arm;Award;career;career development;chronic pain;chronic pain management;chronic pain patient;chronic painful condition;Clinic;Clinical;Cluster randomized trial;Communities;community based participatory research;cost;Cost Analysis;Cost Measures;COVID-19 pandemic;Data;design;Educational workshop;Effectiveness;effectiveness evaluation;effectiveness measure;effectiveness outcome;effectiveness/implementation trial;Electronic Health Record;Emergency department visit;Enrollment;Environment;Epidemic;Epidemiologist;Epidemiology;experience;Feasibility Studies;Federally Qualified Health Center;Feedback;Future;Geography;Gills;Goals;Grant;Guidelines;Health care facility;health economics;Health Personnel;Health Policy;Health Services Accessibility;hybrid type 2 trial;Hybrids;implementation cost;implementation design;implementation evaluation;implementation outcomes;implementation research;implementation science;implementation strategy;implementation/effectiveness;Improve Access;improved;instructor;Integrative Medicine;Intervention;Interview;K-Series Research Career Programs;Low income;Low Income Population;Maintenance;Maps;Measures;Medical;medical schools;Medicine;Mentors;Mentorship;Methods;mindfulness;mindfulness-based stress reduction;Neighborhood Health Center;North Carolina;Opioid;opioid overdose;opioid use;Overdose;overdose death;Pain;Pain management;pain reduction;Patient Isolation;Patient Representative;Patients;Persons;Pharmaceutical Preparations;Pilot Projects;Policy Maker;Population;Populations at Risk;Preparation;prescription opioid;primary care provider;primary health center;programs;Provider;Public Health Schools;Publishing;Quality of life;Recommendation;Research;Research Personnel;Research Project Grants;Research Training;responsible research conduct;retention rate;Risk;risk mitigation;Rural;safety net;scale up;Science;Scientist;Self Efficacy;Self Management;Site;skills;Structure;Surveys;teacher;Techniques;telehealth;theories;Training;Training Activity;Training and Infrastructure;Training Programs;treatment as usual;trial design;Visit;Writing;Yoga

PROJECT_TITLE: Scaling-Up Integrative Pain Management in Federally Qualified Health Centers


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE) Children in foster care are exposed to poverty, maltreatment, and out-of-home placement, contributing to poorer physical and behavioral health outcomes than other children in poverty. This study seeks to improve the health of children in foster care by using 12 years of linked child welfare and electronic health records (EHR) data (N ~ 9,600 patients) in combination with Medicaid claims data and caregiver and self-reported health status to evaluate the impact of healthcare delivery models on health outcomes for foster youth and examine factors associated with variation in healthcare use and health outcomes. Understanding relations between healthcare use and health outcomes can inform healthcare systems interventions that parlay to better health outcomes, with potential for spread, leading to long-term improvements in health for foster youth nationwide.

PI_NAMEs: BEAL, SARAH  (contact)

PROGRAM_OFFICER_NAME: COA, KISHA

PROJECT_TITLE: Examining the impact of healthcare systems changes on healthcare use and health outcomes for children in foster care

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Characterizing genetic signatures of natural selection on the human genome is fundamental to understand human evolutionary history and human diseases. In this proposal, we will develop and apply methods aiming at characterize the genetic signatures of natural selection (1) shaping the genetic architecture of human complex traits, (2) leading to different gene regulation and allele effect sizes across diverse ancestry groups, and (3) acting on genes at the exon and regulatory levels. To reach that goal, we will leverage large GWAS datasets, a new powerful conservation dataset, and multi-ancestry single-cell sequencing dataset.

PI_NAMEs: GAZAL, STEVEN  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Alleles;Asian ancestry;Base Pairing;Chromosome Mapping;Clinical Research;Communities;Complex;Data;Data Set;Development;Diagnosis;Diagnostic;Disease;Disparate;Enhancers;European ancestry;Evolution;Exons;Gene Expression Regulation;Genes;Genetic;genetic architecture;genetic signature;genetic variant;genome wide association study;genomic data;Genomics;Goals;Heritability;Human;human disease;Human Genome;improved;Knowledge;Low Prevalence;Mammals;Medical Genetics;Methodology;Methods;Modeling;Natural Selections;novel;polygenic risk score;Population Genetics;Prevention;Recording of previous events;Resolution;Shapes;simulation;single cell sequencing;single-cell RNA sequencing;statistics;trait;Variant;Work

PROJECT_TITLE: Characterizing genetic signatures of natural selection to understand human diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE: Myocardial infarction is a leading cause of morbidity and mortality in developed societies. Although therapies have improved outcomes, cardiomyocytes, the muscle cells of the heart, are lost because these cells lack significant regenerative capacity. This project will investigate how one signaling pathway, involving a kinase and inhibitors, may work to improve heart function after myocardial infarction.

PI_NAMEs: WOLF, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Ablation;Address;Adult;Apoptosis;Arrhythmia;Blood capillaries;candidate identification;Cardiac Myocytes;Cardiovascular Diseases;Cell Cycle;Cells;Cessation of life;Clinical;Data;density;design;Development;Diphtheria Toxin;druggable target;event cycle;functional improvement;Future;Genetic;Goals;Harmine;Heart;Heart failure;heart function;Hyperplasia;improved;improved outcome;inducible Cre;Infarction;inhibitor;Injury;Investigation;Ischemia;ischemic cardiomyopathy;Knock-out;Knockout Mice;Left Ventricular Function;Left Ventricular Remodeling;Morbidity - disease rate;mortality;mosaic analysis;Mus;Muscular Atrophy;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardial Reperfusion;Myocardium;Neonatal;novel;Outcome;paracrine;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Regenerative capacity;Reperfusion Therapy;Reporter;Ribosomal Proteins;RiboTag;secretory protein;Signal Pathway;Signal Transduction;Societies;Specificity;Technology;Testing;therapeutic target;Transcript;Transgenic Mice;Tyrosine Phosphorylation;Ventricular Function;Work

PROJECT_TITLE: DYRK1a as a therapeutic target to treat myocardial infarction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Narrative In previous work, we have found that brain responses to different stimuli are more confusable (less distinctive) in older vs. younger adults and that age differences in the brain’s major inhibitory neurotransmitter (GABA) play a role. We propose to track neural distinctiveness and GABA in healthy people over a decade as well as in patients with Mild Cognitive Impairment in order to test if these neural measures predict behavioral impairments. This work could inform efforts to alleviate behavioral deficits associated with normal and pathological aging.

PI_NAMEs: POLK, THAD A (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: abeta accumulation;Age;age difference;age group;age related;age related changes;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;Animals;Autopsy;Behavior;behavior prediction;behavior test;Behavioral;behavioral impairment;Brain;Childhood;Cognition;Cognitive;Cohort Effect;Cross-Sectional Studies;Data;Education;Exhibits;experience;Functional Magnetic Resonance Imaging;Funding;gamma-Aminobutyric Acid;Grant;Growth;healthy aging;imaging study;Individual;Individual Differences;insight;interest;Intervention;Longitudinal Studies;Magnetic Resonance Spectroscopy;Measures;Mediating;Michigan;mild cognitive impairment;Modeling;Motor;neural;Neurofibrillary Tangles;neuropathology;Neurotransmitters;new therapeutic target;normal aging;novel;nutrition;older adult;Participant;pathological aging;Patients;Persons;Positron-Emission Tomography;recruit;Research;Research Personnel;response;Sample Size;Senile Plaques;Sensory;Stimulus;tau Proteins;Testing;Time;Work;young adult;β-amyloid burden

PROJECT_TITLE: Investigating age-related neural dedifferentiation longitudinally and in Alzheimer’s pathology

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: NARRATIVE Influenza hemagglutinin is a model system for studying the mechanism by which enveloped viruses fuse membranes during entry into cells. The proposed research will lead to a better understanding of the mechanism of influenza and SARS-CoV-2 entry, specifically, and class-I viral membrane fusion in general. We will also biophysically evaluate avian influenza strains, as well as human pandemic strains that originated in birds to determine the mechanistic features that avian strains must acquire to infect humans.

PI_NAMEs: MUNRO, JAMES B (contact);SOMASUNDARAN, MOHAN

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 2019-nCoV;Address;Adopted;Adoption;Apical;Avian Influenza;Avian Influenza A Virus;Binding;Binding Sites;Biological Assay;Biological Models;biophysical analysis;biophysical properties;Biophysics;Birds;Cell surface;Cells;Cellular Membrane;Chimeric Proteins;China;cold temperature;combat;Cryo-electron tomography;Data;data exchange;density;Development;Dissociation;Distal;Drug Targeting;emerging pathogen;Endocytosis;endosome membrane;Ensure;env Gene Products;Environment;Equilibrium;Evolution;experimental study;Fluorescence Resonance Energy Transfer;Foundations;Glycoproteins;Goals;Hemagglutinin;Human;Image;In Vitro;Influenza;Influenza A virus;Influenza Hemagglutinin;influenza infection;influenza virus strain;inhibitor;Kinetics;late endosome;Life Cycle Stages;Link;Mediating;Membrane;Membrane Fusion;Membrane Lipids;Modeling;Molecular;Molecular Conformation;molecular dynamics;Morphology;Mutation;next generation;pandemic disease;pandemic potential;Pathway interactions;Peptides;Phenotype;Population;premature;prevent;Public Health;Publishing;receptor binding;Research;Role;SARS-CoV-2 spike protein;sialic acid receptor;Sialic Acids;single molecule;Specificity;Structure;Surface;Testing;Therapeutic;Thermodynamics;tissue tropism;trafficking;transmission process;Viral;viral entry inhibitor;Viral Fusion Proteins;Virion;Virus;Visualization;Zoonoses

PROJECT_TITLE: Biophysical studies of viral membrane fusion proteins

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Mental Health;Neurodegenerative;Neurosciences;Pediatric;Pediatric - AIDS;Prevention

PHR: Project Narrative As a consequence of the widespread availability of antiretroviral therapy, HIV in children and adolescents in sub-Saharan Africa is evolving from a universally fatal illness into a chronic condition, often complicated by comorbidities including depression, cerebrovascular disease, and cognitive impairment. However, there are few longitudinal studies assessing these comorbidities in children and adolescents in low-resource settings. This prospective study of Zambian children and adolescents will identify risk factors and biomarkers for HIV- associated comorbidities that will set the stage for future clinical trials.

PI_NAMEs: BEARDEN, DAVID ROSS (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Adherence;Adolescent;Adult;Affect;Africa;Africa South of the Sahara;Age;Anti-Inflammatory Agents;Anti-Retroviral Agents;antiretroviral therapy;Biological Markers;Blood Platelets;Blood Vessels;Brain Diseases;career;career development;Central Nervous System;Cerebrovascular Disorders;Cerebrum;Characteristics;Child;Childhood;Chronic;Clinical;clinical risk;clinical trial readiness;Clinical Trials;Cognitive;cognitive change;cognitive function;cognitive performance;comorbidity;Complex;Control Groups;Data;depressive symptoms;design;Disease;Encephalopathies;experience;Exposure to;follow-up;Foundations;Future;Goals;high risk;HIV;HIV Encephalopathy;HIV-associated cognitive impairment;HIV-associated neurocognitive disorder;HIV-infected adolescents;Image;imaging biomarker;immune activation;Impaired cognition;improved;Individual;Inflammation;Inflammatory;insight;Intervention Studies;Intervention Trial;Ischemia;Knowledge;Logistic Regressions;Longitudinal Studies;longitudinal, prospective study;Machine Learning;Measures;Mediating;Mental Depression;Mentors;Mentorship;monocyte;nanoformulation;Neuroepidemiology;Neurologic;Neuronal Plasticity;Neuroprotective Agents;Opportunistic Infections;Outcome;Penetration;Performance;Perinatal;Pharmaceutical Preparations;Phenotype;Plasma;Platelet Activation;Platelet Count measurement;Population;predictive modeling;preservation;Prevalence;prevent;Program Development;Prospective Studies;psychiatric comorbidity;random forest;Randomized, Controlled Trials;Recording of previous events;recruit;Regimen;Research;Resource-limited setting;Risk;Risk Factors;Selective Serotonin Reuptake Inhibitor;Serum Markers;sex;skills;Stroke;subclinical depression;support vector machine;Techniques;Testing;therapeutic target;Time;Training;treatment strategy;White Matter Hyperintensity;Zambia

PROJECT_TITLE: Longitudinal Cognitive Outcomes in Children and Adolescents with HIV in Zambia


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE  Degeneration of neurons within the brain and spinal cord lead to cognitive and motor impairment that is debilitating and life-threatening. Genetic forms of neurodegeneration are commonly caused by mutations in RNA- binding proteins, yet little is known about their role in neuronal development, function, and survival. The goal of the proposed study is to develop accurate pre-clinical models for inherited pediatric motor neuron degeneration, and to use these new resources to uncover novel pathogenic disease mechanisms.

PI_NAMEs: SCHAFFER, ASHLEIGH E (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Affect;aging population;Alleles;Animal Model;Animals;Ataxia;Behavioral;Binding;Biogenesis;Brain;Brain Diseases;causal variant;Cell model;Cessation of life;Childhood;Clinical;Cognitive;Data;Defect;Dermal;Disease;disease model;disease phenotype;Disease Progression;DNA Sequence Alteration;effective therapy;Electrophysiology (science);Etiology;Event;Fibroblasts;gain of function;Gene Expression;Gene Expression Profile;gene therapy;Genes;Genetic;genetic manipulation;Genetic Transcription;Goals;High-Throughput Nucleotide Sequencing;Histology;Human;human disease;human induced pluripotent stem cells;human stem cells;Immunohistochemistry;Impaired cognition;In Vitro;in vivo;Inherited;innovation;Knock-out;Knowledge;Lead;Life;Measures;Mediating;Messenger RNA;Modeling;Molecular;Molecular Profiling;Motor;motor behavior;motor deficit;motor disorder;motor impairment;motor neuron degeneration;Motor Neuron Disease;Motor Neurons;mouse genetics;Mus;mutant mouse model;Mutant Strains Mice;Mutation;Nerve Degeneration;Nervous System Disorder;Neuroblastoma;Neurodegenerative Disorders;neuron development;Neuronal Dysfunction;Neurons;novel;Onset of illness;overexpression;Pathogenesis;Pathogenicity;Pathology;Patients;Pattern;Peripheral Nervous System;Phenotype;Phosphotransferases;Physiological;Polyadenylation;Pontocerebellar hypoplasia;Pre-Clinical Model;Prevalence;prevent;protein function;Protein Isoforms;Refractory;Repression;Resources;RNA;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;Seizures;spasticity;Spinal;Spinal Cord;Structure;System;Testing;Therapeutic;therapeutic target;Tissues;tool;transcriptome sequencing;Transfer RNA;Variant

PROJECT_TITLE: Disease Mechanisms of Pontocerebellar Hypoplasia Type 10

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ORG_CITY: COLUMBIA

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative Research suggests post-operative pain management should be patient-centered and differ across patients based on many factors including pain experience and pain tolerance. A clinical decision support (CDS) tool based on patient data from the EHR is needed to implement a patient-centered opioid discharge guideline. This project will integrate the guideline as a patient-centered opioid prescribing tool (PCOPT) into the EHR of a regional health system andassess its effects on patient-centered guideline opioid discharge compliance and patient outcomes.

PI_NAMEs: BROOKS, JOHN M (contact);LITWIN, ALAIN HARRIS

PROGRAM_OFFICER_NAME: KATO, ELISABETH

PROJECT_TITLE: The Development and Evaluation of a Patient-Centered Opioid Discharge Prescribing Guideline within the Electronic Health Record of a Health System

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ORG_CITY: VILLANOVA

ORG_NAME: VILLANOVA UNIVERSITY

PHR: Project Narrative Prevention and reduction of healthcare-associated infections (HAI) is one of the most important patient safety issues in U.S. hospitals and a major public health concern. Although 35-55% of all HAI are preventable, approximately 1 in 25 acute care patients in the U.S. will experience at least one HAI during hospitalization. Results from this study will inform both clinicians and policy makers on the evolving nature of infection control in hospitals and the staffing resources needed to ensure that HAI are prevented.

PI_NAMEs: DE CORDOVA, PAMELA BLYTHE;POGORZELSKA-MAZIARZ, MONIKA  (contact)

PROGRAM_OFFICER_NAME: MILLER, MELISSA

PROJECT_TITLE: Prevention of Infections Through Appropriate Staffing (PITAS)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]