NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed randomized control trial challenges the dogma of symptom-based diagnosis and empiric management of gastroesophageal reflux disease (GERD) in high-risk convalescing infants by seeking objective evidence criteria and testing the efficacy of natural maturation, acid- suppressive medication (proton-pump inhibitor) and added rice cereal formula with equipoise. The diagnosis of GERD and the consequences of its therapies, e.g., the added burden of an extra $70k and 30 days of hospitalization per infant, are a highly relevant public health concern. Our study will likely overcome the critical barrier to progress by providing the scientific basis of managing vulnerable infants, thereby enhancing digestive health, overall nutrition, growth, and quality of life in infants, all relevant to the mission of NIH (NIDDK).

PI_NAMEs: JADCHERLA, SUDARSHAN R (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Acids;Adverse effects;Age;Algorithms;arm;associated symptom;Benchmarking;Biological Markers;Caring;Categories;Cereals;Characteristics;Childhood;Chronology;Clinic Visits;Clinical;clinical efficacy;Clinical Trials;comparative efficacy;cost;Coughing;Data;decision making algorithm;design;Diagnosis;Diagnostic;diagnostic algorithm;diagnostic criteria;Diagnostic tests;disease diagnosis;Distal;Eating;Economic Burden;Economics;effective therapy;Effectiveness;efficacy testing;electric impedance;Enteral Feeding;Equilibrium;Equipoise;Esophagus;Evaluation;Event;evidence base;Evidence based practice;Evidence based treatment;Failure;feeding;Feeding Methods;Feeds;follow-up;Future;Gastroesophageal reflux disease;Goals;Growth;Health;high risk;high risk infant;hospital readmission;Hospitalization;Hour;improved;indexing;Infant;inhibitor;Intake;Intervention;Knowledge;Length of Stay;Measurement;Mission;Modification;National Institute of Diabetes and Digestive and Kidney Diseases;Neonatal;Neonatal Intensive Care Units;Neurologic;novel;novel diagnostics;Nutrient;nutrition;Oral;Outcome;Parents;Pathologic;Peripheral;Pharmaceutical Preparations;Physiological;Population;Pregnancy;Prevalence;primary endpoint;primary outcome;Probability;programs;Proton Pump Inhibitors;Provider;Public Health;Pump;Quality of life;Randomized;Randomized, Controlled Trials;Relative Risks;Research;Research Personnel;response;Rice;Safety;secondary outcome;Severities;Severity of illness;skills;socioeconomics;stem;Stratification;success;Symptoms;Testing;Therapeutic;Therapeutic Effect;Time;Treatment Efficacy;treatment group;treatment response;Tube;United States National Institutes of Health;unnecessary treatment;Variant;Vomiting;Work

PROJECT_TITLE: Pathophysiological Evidence Driven Management of GERD in Neonatal ICU Infants: Randomized Controlled Trial

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Kidney Disease

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Narrative Megalin captures proteins from the urinary space to produce an essentially protein-free urine, thereby protecting the kidney tubules from damage caused by proteinuria. Megalin recycles between cell surface and intracellular compartments to carry out this function, but the molecular basis for this recycling is not well understood. I will use structural approaches to study the molecular basis of its recycling.

PI_NAMEs: BEENKEN, ANDREW S (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: absorption;Adopted;Advisory Committees;Affinity;Albumins;Alkalinization;Amino Acids;Apical;apical membrane;Award;Back;Basic Science;Binding;Binding Proteins;Binding Sites;Biological Assay;Biological Markers;Bowman's space;Cardiovascular system;career;career development;Cell membrane;Cell surface;Cells;chelation;Chronic Kidney Failure;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cryoelectron Microscopy;Dependence;design;Didelphidae;Disease;Dissociation;Early Endosome;Egtazic Acid;Endocytosis;Endosomes;Epithelial Cells;Event;experience;experimental study;Filtration;Future;glomerular filtration;Goals;Immunofluorescence Immunologic;Institution;Intervention;Ions;kidney cell;Laboratory Research;late endosome;LDL-Receptor Related Protein 2;Life Cycle Stages;Ligand Binding;Ligands;Mass Spectrum Analysis;Mediating;Mentors;Molecular;Molecular Chaperones;Molecular Weight;mutant;Mutate;Mutation;particle;Physicians;Process;protein complex;protein structure;Proteins;Proteinuria;Proximal Kidney Tubules;Publishing;receptor;receptor recycling;reconstruction;Recycling;Regulation;Renal tubule structure;Research;Research Personnel;Research Project Grants;Scientist;Signal Transduction;Sorting;stoichiometry;structural biology;Structure;Surface;Surface Plasmon Resonance;Testing;trafficking;Training;Translating;Tubular formation;Universities;urinary;Urine;Variant;Work

PROJECT_TITLE: Structural regulation of megalin recycling in the proximal tubule

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Anhedonia, the inability to seek-out and experience pleasure, is a common symptom in depression that predicts treatment-resistance and is sometimes exacerbated by first-line antidepressants. Anhedonia decreases goal-directed behavior and related neural activity. The research generated in this proposal will investigate which neural circuits play a causal role in goal-directed behavior, how enhancing related neural activity increases goal-directed behavior, and target engagement in a potential treatment paradigm of five-consecutive days of stimulation in depressed patients with anhedonia.

PI_NAMEs: RIDDLE, JUSTIN M (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Anhedonia;anti-depressive agents;arm;Behavior;Biological;Biology;Brain;Cephalic;Clinical Research;Clinical Trials;cognitive process;common symptom;Corpus striatum structure;Coupling;Data;Decision Making;Depressed mood;depressed patient;determinants of treatment resistance;Development;Diagnostic;Dissociation;Dorsal;Electroencephalography;Evaluation;Expenditure;experience;experimental study;falls;follow-up;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Goals;Impairment;improved;innovation;insight;Intervention;Investigation;Knowledge;Lateral;Major Depressive Disorder;Medial;Mental Depression;Mental disorders;Moods;National Institute of Mental Health;network models;neural;neural circuit;neurophysiology;noninvasive brain stimulation;novel;Participant;Patients;Performance;Periodicity;Phase;Placebos;Play;pleasure;Positive Valence;precision medicine;Prefrontal Cortex;programs;Protocols documentation;randomized, clinical trials;Research;Research Domain Criteria;Research Training;Resolution;Rewards;Role;Scalp structure;Schizophrenia;Severities;Substance Use Disorder;Symptoms;System;systems research;tool;Transcranial magnetic stimulation;Ventral Striatum;Work

PROJECT_TITLE: Causal role of delta-beta coupling for goal-directed behavior in anhedonia

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AR

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Emergency Care;Machine Learning and Artificial Intelligence;Neurosciences;Opioids;Pain Research;Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: RIVANNA MEDICAL, INC.

ORG_STATE: VA

PHR: PROJECT NARRATIVE For the >330,000 Americans hospitalized annually for hip fractures, acute pain is primarily managed through parenteral opioids, which are associated with increased delirium, increased length of stay, and recurrent opioid use after initial exposure in the emergency department (ED). Although alternative hip fracture pain management techniques are employed in the ED that are proven to reduce opioid usage and improve outcomes, such as the pericapsular nerve group (PENG) block, broad utilization is limited by lack of access to the training required to achieve competency and challenging workflow requirements. The goal of this project is to develop and validate an ultrasound-based regional anesthesia guidance system that provides workflow intelligence to overcome barriers to ED use of the PENG block, increases utilization of the technique, and ultimately improves patient access to opioid-sparing analgesia for hip fracture pain.

PI_NAMEs: MAULDIN, FRANK WILLIAM (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: 3-Dimensional;Absence of pain sensation;Accident and Emergency department;Acute;Acute Pain;Address;Admission activity;adverse event risk;adverse outcome;Algorithms;American;Anatomy;Anesthesia procedures;bone;Cadaver;Certification;Clinical;clinical application;clinical trial readiness;Collaborations;commercial application;commercialization;Competence;Computer software;Conduction Anesthesia;deep learning;Delirium;design;Detection;Development;Emergency Department Physician;experience;fabrication;falls;Funding;Goals;Helping to End Addiction Long-term;hip bone;Hip Fractures;Hip region structure;Hospitalization;Hospitals;Human;human imaging;Image;image guided;image visualization;imaging study;imaging system;improved;improved outcome;Injections;innovation;Intelligence;International;Intuition;Learning;learning network;Length of Stay;Machine Learning;manufacture;Manufacturer;Marketing;Measurement;Medical Device;Methodology;Modality;mortality risk;Needles;Nerve;Nerve Block;non-opioid analgesic;Nonpharmacologic Therapy;novel;Operative Surgical Procedures;Opioid;opioid sparing;opioid use;Pain;Pain management;Patients;Persons;Phase;Physicians;point of care;Positioning Attribute;pre-clinical;preclinical study;primary endpoint;Procedures;product development;Production;prototype;Provider;Reader;reconstruction;Recurrence;Research Project Grants;response;Risk Reduction;Sensitivity and Specificity;Site;soft tissue;Specific qualifier value;Specimen;standard of care;Sterility;success;System;Techniques;technological innovation;Technology;Tendon structure;therapy development;Three-Dimensional Imaging;Time;Training;Ultrasonography;ultrasound;usability;Validation;validation studies;Work;X-Ray Computed Tomography

PROJECT_TITLE: Development of a regional anesthesia guidance system to increase patient access to opioid-sparing analgesia for hip fracture pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-C(10)B]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LAC DU FLAMBEAU

ORG_NAME: GREAT LAKES INTER-TRIBAL COUNCIL, INC.

ORG_STATE: WI

PHR: NARRATIVE: GLNARCH OVERALL  This Great Lakes Native American Research Centers for Health (GLNARCH) is housed at the Great Lakes Inter-Tribal Council. This application aligns established partnerships to promote a synergistic education, training, and research within the Indian Health Service Bemidji Region with increased focus on including Tribal Colleges and Universities (TCUs). This application proposes an unprecedented endeavor to engage AI/AN populations in an indigenized (culturally responsive) research and training agenda. The Center is composed of an Administrative Core, Capacity Building project (NEHR), a Career Enhancement project (SCEP), and a Pilot Project.

PI_NAMEs: DELLINGER, MATTHEW J;LAVERDURE, ADRIENNE  (contact)

PROGRAM_OFFICER_NAME: BISSONETTE, GREG

PROJECT_TERMS: Address;Advisory Committees;American Indian Women;Area;career;Communities;community partnership;Consultations;Data Collection;data management;Databases;digital;Distance Learning;Education;Ensure;Environment;Environmental Health;Evaluation;Evaluation Reports;Event;experience;Exposure to;Facebook;Film;Funding;Funding Mechanisms;gender-based violence;Geography;Goals;Great Lakes Region;healing;Health;health application;Health Service Area;help-seeking behavior;higher education;Holistic Health;improved;Indigenous;Institution;interest;Internships;intertribal;Investigation;Lac du Flambeau;learning strategy;meetings;Michigan;Minnesota;Modernization;Multicultural Education;Native American Research Center for Health;Native Americans;Natural Resources;novel;Outcome;outreach;Participant;Persons;Pilot Projects;Population;Program Evaluation;programs;Publishing;Research;Research Personnel;Research Project Grants;Research Support;Reservations;Resource Sharing;Resources;Rural;Science;Scientist;Self Efficacy;skills;social media;Strategic Planning;Students;Survivors;symposium;Technology;Training;tribal college;tribal community;Tribal Council;Tribal Elders;tribal organization;Tribes;United States Indian Health Service;Universities;Update;virtual;web site;Wisconsin

PROJECT_TITLE: Great Lakes NARCH  - Expanding Community Partnerships


ADMINISTERING_IC: CA

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Palliative Care

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE This project will demonstrate the efficacy of a family-focused meditation intervention to improve depressive symptoms and spiritual wellbeing relative to an attention control and a usual care control group in a diverse sample of patients with metastatic cancer and their family caregivers.

PI_NAMEs: MILBURY, KATHRIN  (contact)

PROGRAM_OFFICER_NAME: ETON, DAVID T

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Affect;Area;arm;Attention;attentional control;Behavior;Behavioral Medicine;Behavioral Sciences;Cancer Family;Cancer Patient;cancer therapy;Caregivers;Caring;Cessation of life;clinical care;Community Hospitals;comparison group;Control Groups;coping;Data;depressive symptoms;Devices;Diagnosis;Disease;Disease Progression;Disseminated Malignant Neoplasm;Distress;Dose;efficacious intervention;efficacy trial;Emotional;emotional disclosure;end of life;end of life care;Enrollment;Ensure;evidence base;Exercise;experience;Family;Family Caregiver;Feeling hopeless;Feeling suicidal;follow-up;Fostering;Fright;Future;Goals;high risk;Hospice Care;hospital care;Immunotherapy;improved;in vivo;innovation;Intervention;Intervention Studies;Knowledge;Latino;Life;Literature;Malignant Neoplasms;Manuals;Measurement;Meditation;Mental Depression;Methods;Nature;negative affect;novel;Outcome;Palliative Care;Participant;patient population;Patient Self-Report;Patients;peace;Personal Satisfaction;pilot test;Population;Population Heterogeneity;positive emotional state;preference;primary outcome;Procedures;Prognosis;prognostic value;programs;psychologic;psychological distress;Psychology;psychosocial;Psychosocial Assessment and Care;Randomized;Randomized, Controlled Trials;recruit;Sampling;secondary outcome;Self Assessment;Site;Social support;Solid;Spanish;Spiritual well-being;Spirituality;stressor;Supportive care;Symptoms;Techniques;tool;Translating;Translations;treatment arm;treatment as usual;Treatment Efficacy;trial comparing;usual care arm;Videoconferencing;Work

PROJECT_TITLE: Psycho-Spiritual Management for Patients with Advanced Cancer and their Family Caregivers


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE: GLNARCH XII Administrative Core  The GLNARCH administrative core is a team who have promoted health science careers and research within the Bemidji Region since 2003. This Great Lakes Native American Research Centers for Health (GLNARCH) application aligns established partnerships to generate a network of resources for AI/AN consortia as well as continue support for our impactful programs. The overall mission of the GLNARCH Administrative Core is to ensure the AI/AN Tribes remain central to NARCH.

PI_NAMEs: LAVERDURE, ADRIENNE  (contact)

PROJECT_TERMS: Administrative Coordination;Advisory Committees;Award;Biomedical Research;career;Chippewa;Chronic;Communication;Communities;community engagement;community partnership;Contracts;Data;Data Collection;data management;Development;digital;Distance Learning;Education;electronic data;Ensure;Environment;Epidemiology;Equity;Evaluation;Event;Family;Fostering;Funding;Geography;global health;Goals;Grant;Health;health application;health equity;Health Promotion Sciences;Health Service Area;improved;Indigenous;innovation;intertribal;Knowledge;Lac du Flambeau;learning strategy;Maps;medical schools;meetings;Mission;Modeling;Native American community;Native American Research Center for Health;Newsletter;novel;Outcome;parenting intervention;Pilot Projects;programs;Qualitative Methods;Reporting;Research;Resources;Role;Science;Students;success;Survey Methodology;synergism;System;Telecommunications;Time;Training;tribal college;tribal community;Tribal Council;Tribal group;tribal leader;tribal Nation;Tribes;Turtles;United States Indian Health Service;United States National Institutes of Health;Universities;Update;Vision;Wisconsin;Work

PROJECT_TITLE: GLNARCH 12 Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-N]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

PHR: NARRATIVE: Pilot Project, Healing from Within.  The proposed pilot study uses a mixed-methods and community engaged approach to identify and understand barriers to help-seeking among Indigenous women with co-occurring mental health and/or substance use disorders after experiences of gender-based violence, and to understand how resiliency and cultural identity may help to motivate help- seeking among Indigenous women survivors of GBV in the local context of Wisconsin. This proposed pilot study is the first of its kind in Wisconsin by being Indigenous led, and through the formation of academic community partnerships between universities, 3 of Wisconsin’s 11 federally recognized tribes, Indigenous-led organizations, and tribal community leaders across the State.

PI_NAMEs: LUEBKE, JENEILE MARIE (contact)

PROJECT_TERMS: Address;Advisory Committees;American Indian Women;Area;barrier to care;career;Cessation of life;Clinic;Communities;community academic partnership;community advisory board;community based participatory research;community collaboration;community engaged approach;community engaged research;community partners;community partnership;Complex;County;Data;Elderly;Ensure;Environment;experience;forest;Foundations;Future;Gender;gender-based violence;healing;Health;health care availability;health disparity;health equity promotion;Health Priorities;Health Promotion;help-seeking behavior;Home;improved;Indigenous;indigenous community;Individual;Inequality;Institution;Interview;Investigation;Knowledge;Life;Mainstreaming;meetings;Mental disorders;Mental Health;Methodology;Methods;Midwestern United States;Motivation;Murder;Native American Research Center for Health;Native-Born;Outcome;Pattern;Personal Satisfaction;Pilot Projects;Policies;Potawatomi;Prevalence;Provider;racism;Recommendation;recruit;Reduce health disparities;relationship abuse;Reporting;Research;Research Personnel;research study;reservation-based;resilience;resilience factor;Resources;response;restraint;Risk;Rural;rural area;Safety;Services;severe injury;Shapes;Shelter facility;social stigma;structural determinants;substance misuse;substance use;Substance Use Disorder;Surveys;Survivors;tribal community;tribal health;tribal Nation;Tribes;Trust;Universities;urban area;Violence;Wisconsin;Woman

PROJECT_TITLE: Healing From Within: Identifying and Understanding the Intersecting Barriers to Help-seeking After Experiences of Violence for Wisconsin American Indian Women Through Survivor-led Research


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: BIRMINGHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE In this investigation, we will use nuclear imaging to study the in vivo behavior and health effects of polystyrene micro- and nanoplastics in mammals under environmentally relevant concentrations. Determining the biodistribution, biokinetics, and bioretention of these materials will shed light upon the mechanisms of their toxicity and has the potential to impact decision-making on the remediation of plastic pollutants as well as the exposure of workers and the public to these materials.

PI_NAMEs: KEINAENEN, OUTI MARIA (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: absorption;Air;Animals;Autoradiography;Behavior;bioaccumulation;Biodistribution;Biological;Biological Markers;Biological Models;Cardiovascular system;career;career development;Chelating Agents;Chronic;collaborative environment;college;Communication;Consumption;Data;Decision Making;Deposition;Disease;Dose;drinking water;Employment;Environment;Environmental Pollutants;Environmental Pollution;Evaluation;experimental study;exposed human population;exposure route;Exposure to;Fetal Development;Food;Foundations;Fresh Water;Future;Goals;Grant;Health;Histology;Human;Image;imaging approach;Imaging Techniques;Immunohistochemistry;In Vitro;in vivo;in vivo evaluation;Inflammation;Inflammatory;Inflammatory Response;Ingestion;Inhalation;innovation;Interdisciplinary Study;Intestines;Investigation;Iodine Radioisotopes;Label;Laboratories;Light;Liquid substance;Lung;Mammals;Mentors;meter;Methods;Microscopic;Modeling;molecular imaging;Mus;Musculoskeletal System;Nervous System;nuclear imaging;Nulliparity;Oral;Outcome;particle;Particle Size;Pharmacology and Toxicology;Pharmacology Study;Phase;Physiological;Placenta;Plastics;pollutant;Polystyrenes;Positron-Emission Tomography;Postdoctoral Fellow;pre-clinical;Pregnancy;pregnant;Process;programs;Proliferating;Radiochemistry;Radiolabeled;Radiopharmaceuticals;radiotracer;remediation;Research;research and development;Resources;Role;Route;Seawater;Sewage;Shapes;sialic acid binding Ig-like lectin;Site;skills;Soil;Stomach;Structure;Surface;Techniques;Time;Tissues;tool;Toxic effect;Tracer;trend;uptake;Visualization;Work

PROJECT_TITLE: Harnessing PET to Study the In Vivo Fate and Health Effects of Micro- and Nanoplastics


ADMINISTERING_IC: EY

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: LEWISTON

ORG_NAME: BATES COLLEGE

ORG_STATE: ME

PHR: Project Narrative Many types of blindness result from the neurons of the retina no longer being able to communicate with the brain due to injury or disease. In mammals, the adult retina cannot make new retinal ganglion cells (the neurons that connect the retina with the brain) to replace those that are lost. In this project, I aim to learn about normal development of retinal ganglion cells and, further, to make new retinal ganglion cells from retinal cell types that can divide and produce neurons in adults.

PI_NAMEs: WOODWORTH, MOLLIE BURGOON (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Adopted;Adult;Advisory Committees;Affect;Award;Biological Sciences;Blindness;Brain;career;cell injury;cell type;Cells;Cerebral cortex;Cessation of life;Chickens;Clinical;Communication;Communities;Data;Defect;Department chair;Development;Developmental Biology;Developmental Process;Diabetic Retinopathy;Disease;Economic Burden;Ectopic Expression;experimental study;Eye;Eye diseases;Faculty;gain of function;Generations;Genes;Genetic;Glaucoma;Goals;Hereditary Retinal Dystrophy;Human;improved;in vivo;Induced Neurons;Injury;innovation;insight;Knowledge;Laboratories;Learning;loss of function;Mammals;Medical;Medical Care Costs;medical schools;member;Mentors;Methods;Muller's cell;Mus;Natural regeneration;Nervous System;neural;neurogenesis;Neuroglia;neuron development;neuron regeneration;Neurons;Neurosciences;Ophthalmology;Optic Nerve Injuries;Output;overexpression;Phase;Population;postmitotic;Productivity;programs;Protocols documentation;Quality of life;regenerative;regenerative cell;regenerative therapy;repaired;Research;Resources;Retina;retinal ganglion cell regeneration;Retinal Ganglion Cells;retinal neuron;retinal progenitor cell;retinal regeneration;Science;Shapes;Societies;Training;transcription factor;United States;Universities;vision science;Visual impairment;Work;Zebrafish

PROJECT_TITLE: Development and Regeneration of Retinal Ganglion Cells in the Vertebrate Retina


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: This project will investigate brain changes that occur throughout the first year of formal schooling, a year  of foundational learning that has consequences for future academic attainment and other major life  outcomes. Understanding the brain mechanisms that support emerging reading and mathematics  throughout this first year is crucial for developing biomarkers that can identify children at risk of future  difficulties and may identify windows of great plasticity within the first-grade year for optimal intervention.

PI_NAMEs: VINCI-BOOHER, SOPHIA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 6 year old;7 year old;Address;Adult;Algorithms;Architecture;Artificial Intelligence;Awareness;Biological Markers;Brain;Brain scan;Categories;Child;Childhood;Cognitive;cognitive neuroscience;Communities;computational neuroscience;computer science;Computer Vision Systems;Data;Data Set;deep learning model;Development;Digit structure;Discipline;early childhood;Education;Educational Intervention;Educational workshop;elementary school;Emotional;experience;Face;first grade;Functional Magnetic Resonance Imaging;Future;Goals;Growth;hands-on learning;Human;human model;Image;insight;Intervention;Investigation;Knowledge;Learning;Letters;Life;literacy;Magnetic Resonance Imaging;mathematical ability;mathematical learning;Mathematics;Measures;Medical;Methodology;Methods;Motor;neural;neuroimaging;neuroinformatics;Neurosciences;Outcome;Process;Public Health;Reading;reading ability;Research;Research Infrastructure;Resources;response;Risk;Role;Sampling;Schools;Science;Sesame - dietary;social;Software Tools;statistics;Structure;System;Techniques;Time;timeline;Training;Visual

PROJECT_TITLE: CRCNS: Dense longitudinal neuroimaging to evaluate learning in childhood

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(50)R]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Neurocognitive impairment (NCI) in HIV common and as people with HIV (PWH) live longer and experience higher rates of comorbidities, rates of NCI are likely to increase. This study will develop exploratory multimodal (e.g., demographic, medical, inflammation) longitudinal phenotypes of NCI risk among aging Malaysians with HIV. To do so, we will also adapt and validate the NeuroScreen neurocognitive testing tablet app for use in Malaysia and generate locally derived norms and NCI cut-off scores for its use there and in phenotype development.

PI_NAMEs: ROBBINS, REUBEN N (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Adolescent;Adult;Affect;Age;Aging;Behavioral;Big Data;Brain;Caring;Chronic;Clinical;clinical care;Clinical Research;cohort;comorbidity;Computer Literacy;cost;Country;Data;Data Set;Decision Making;dementia risk;design;Detection;Development;Disease;epidemiology study;ethnic diversity;Evaluation;experience;Face;General Population;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human immunodeficiency virus test;Immune response;Impairment;Income;Inflammation;Inflammatory;Institution;instrument;Interdisciplinary Study;Internet;Intervention;Knowledge;Language;longitudinal dataset;low and middle-income countries;Machine Learning;Malaysia;Malaysian;Measures;Medical;medication compliance;meetings;mortality;Multilingualism;multimodal data;multimodality;neuroAIDS;Neurocognition;Neurocognitive;Neurocognitive Deficit;neurocognitive test;Neuropsychology;Older Population;Participant;Pathogenesis;Patients;Persons;Phenotype;Population;Prevalence;Prevention;Provider;Psychometrics;Psychosocial Stress;Research;research in practice;Research Project Grants;Resources;Risk;Risk Factors;sociodemographics;Socioeconomic Factors;socioeconomics;South Africa;Statistical Data Interpretation;Tablets;Techniques;Testing;Thailand;Time;timeline;tool;Translations;usability;Visit

PROJECT_TITLE: Building Resources to Assess Impaired Neurocognition for Care and Research among Adults Aging with HIV (BRAIN Care HIV)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Sepsis

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Sepsis is a leading cause of death in patients with severe burn injury, accounting for nearly 75% of mortality among burn patients. However, it is difficult to detect burn patients at higher risk of sepsis at the time of intensive care unit presentation and recognize sepsis in burn patients. In this proposal, we will use proteomics analysis of immune dysregulation and cardiovascular injury to define sub-phenotypes of patients and linked to the risk of secondary sepsis in burn patients and identify proteomic signatures specific to sepsis.

PI_NAMEs: LEGRAND, MATTHIEU  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Accounting;Adult;Anti-Inflammatory Agents;Antibiotic Prophylaxis;Antibiotics;Biological Assay;Biological Markers;biomarker identification;biomarker signature;Body Surface Area;Burn injury;Burn Units;cardiovascular injury;Cardiovascular system;Cause of Death;Clinical;Clinical Data;cohort;Critical Illness;cytokine;Data;Diagnosis;Early identification;Endothelium;Enrollment;Functional disorder;Future;Goals;high risk;high risk population;Immune;Immune response;immunoregulation;improved;improved outcome;Infection;Inflammatory;Inflammatory Response;insight;Intensive Care Units;Intervention;Knowledge;Length of Stay;Link;longitudinal analysis;Measures;Metabolism;Molecular;mortality;mortality risk;Multiple Organ Failure;Organ failure;organ injury;Outcome;Pathway interactions;patient population;Patients;Pattern;Permeability;Pharmaceutical Preparations;Phenotype;Physiological;Plasma;Population;potential biomarker;Predictive Value;prevent;Prevention strategy;preventive intervention;primary endpoint;Production;prophylactic;prospective;Prospective, cohort study;proteomic signature;Proteomics;response;Risk;Sampling;secondary infection;secondary outcome;Secondary to;Sepsis;septic;septic patients;Septic Shock;severe burns;Shock;Signs and Symptoms;specific biomarkers;Specificity;systemic inflammatory response;Testing;Therapeutic;Therapeutic Intervention;Time;tool;Translating

PROJECT_TITLE: Identification of sub-phenotypes of severely ill burn patients and risk for secondary sepsis: SEPSISBURN

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative / Public Health Statement Spinal cord injury results in debilitating motor deficits, neuropathic pain, autonomic dysfunction, bladder, bowel, and sexual dysfunction. The objective of this proposal is to inform the design of multi-modal rehabilitation therapies – i.e., those specifically intended to restore multiple functions simultaneously. If successful, this work could lead to a new, more efficacious therapies for individuals living with spinal cord injury.

PI_NAMEs: BANDRES, MARIA FERNANDA (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Address;Anesthesia procedures;Animals;Area;Autonomic Dysfunction;Behavior;Bladder;Bladder Dysfunction;Blood Pressure;Characteristics;Chest;Clinical;clinically relevant;Combined Modality Therapy;Communication;comparative;Complex;design;Development;Doctor of Philosophy;dorsal horn;efficacious treatment;Electric Stimulation;Engineering;Frequencies;Goals;gray matter;Health;Heart Rate;Horns;Impairment;Implant;improved;in vivo;Individual;Injury;innovation;interest;Intestines;lens;Maintenance;Measures;Mental Health;Microelectrodes;Modeling;Motor;motor deficit;motor impairment;Motor Neurons;Motor output;Movement;multimodality;Nervous System Trauma;neural;neural patterning;neurological rehabilitation;Neurons;neuroprosthesis;neuroregulation;neurotechnology;Nociception;Noise;non-opioid analgesic;Pain;pain processing;painful neuropathy;Paralysed;Pattern;Pelvic floor dysfunction;Pelvic Floor Muscle;Pelvic floor structure;Persons;Phase;physical conditioning;Physiology;Population;Postdoctoral Fellow;pre-clinical research;primary outcome;Process;programs;psychologic;Public Health;Quality of life;Rattus;Readiness;Recovery;Reflex action;Rehabilitation therapy;Research;Respiration;restoration;Sensorimotor functions;Sensory;sensory feedback;Sex Functioning;Sexual Dysfunction;spatiotemporal;Spinal;Spinal Cord;Spinal cord injury;Synaptic Transmission;Technical Expertise;Testing;transmission process;Unconscious State;Work

PROJECT_TITLE: Integrative spinal physiology to restore neural control of sensorimotor functions after neurological injury

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Deterioration of kidney function, or acute kidney injury (AKI) is an important contributing factor to the morbidity and mortality of hospitalized veterans. We previously showed that Tamm-Horsfall Protein (THP), a glycoprotein made by the kidney, protects the kidneys in the setting of injury. This projects will validate the use of recombinant THP as a therapeutioc tool to treat AKI. Therefore, this project has improtant direct relevance to veterans health, as it will aid towards the development of recominant THP as a therapeutic drug to be used to treat kidney injury.

PI_NAMEs: ASHKAR, TAREK MAURICE (contact)

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Apical;Award;Biochemical;Cardiovascular Diseases;Cells;Chinese Hamster Ovary Cell;Chronic;Chronic Kidney Failure;Circulation;Cisplatin;clinically relevant;clinically significant;cohort;Communicable Diseases;Data;Deterioration;Development;Disease;Dose;Drug Kinetics;Ensure;Epithelium;Excretory function;experimental study;Fibrosis;Filtration;General Population;Genes;Glycoproteins;Goals;healing;Health;Heterozygote;high risk;Histologic;Hospitalization;Hospitals;Hour;Human;human disease;Immune;improved;Infection;Inflammatory;Injury;injury recovery;Injury to Kidney;interstitial;Ischemia;Kidney;kidney cell;Kidney Diseases;Knock-out;knockout animal;Limb structure;Macrophage;Measurement;Measures;Modeling;Molecular Profiling;Morbidity - disease rate;mortality;Mortality Determinants;mouse model;Mus;Names;new therapeutic target;Operative Surgical Procedures;Outcome;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Pilot Projects;Protein Deficiency;Proteins;Publishing;Recombinants;Regimen;Renal function;Reperfusion Therapy;Research;response;Risk;Safety;Severities;Signal Transduction;Structure of ascending limb of Henle's loop;Supplementation;Testing;Therapeutic;Therapeutic Intervention;Thick;tool;UMOD gene;urinary;Urine;Validation;Veterans;Wild Type Mouse

PROJECT_TITLE: Validation of recombinant truncated Tamm-Horsfall protein as a therapeutic tool for kidney injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NEPH-N (01)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE The emerging field of comparative oncology may provide a novel solution to rare human cancer studies, as genomic resources, reference genomes and non-human model cancer sequencing data are proliferating rapidly. We propose to, for the first time, develop and apply new machine learning methods to jointly analyze and integrate information from hundreds of mammalian genomes to identify pan-mammalian mechanisms of cancer resistance and susceptibility, and apply those insights in human cancers. To disseminate this date to the wider community and catalyze further research we will develop a tumor compendium, portal, and toolkit that will allow other researchers to leverage pan-mammalian comparative genomics.

PI_NAMEs: GRAIM, KILEY  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Administrative Supplement;Adult;Algorithms;Atlases;Biological;Biology;biomedical scientist;cancer gene expression;cancer initiation;Cancer Model;Cancer Patient;cancer risk;cancer subtypes;Canis familiaris;Childhood;Collaborations;Communities;comorbidity;comparative;comparative genomics;Comparative Study;Conserved Sequence;Data;data integration;deep learning;deep learning model;Development;DNA;DNA Sequence;drug development;Early Diagnosis;Effectiveness;Event;Evolution;Florida;Frequencies;gene conservation;Gene Dosage;Genes;Genetic;Genetic Transcription;Genome;genome resource;genome sequencing;genomic data;genomic profiles;genomic profiling;Genomics;Glioma;Goals;Graph;high throughput analysis;Human;Human Biology;human data;human model;Immune;improved outcome;Inbreeding;Incidence;Individual;insight;large scale data;Learning;Link;loss of function;Machine Learning;machine learning framework;machine learning method;machine learning model;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant Neoplasms;mammalian genome;Mammals;Methods;model organism;Modeling;Molecular;Motivation;motivational processes;Mutation;Natural experiment;Neoplasm Metastasis;new therapeutic target;novel;Oncogenes;Oncology;open source library;Osteosarcoma;Pan Genus;Pathway interactions;Patients;Pattern;Phenotype;Platinum;Predisposition;pressure;Process;Proliferating;rare cancer;reconstruction;recruit;reference genome;Reporting;Research;Research Personnel;Resistance;Resources;Risk;Risk Factors;Role;Sample Size;Sampling;Scientist;Sorbus;Structure;Surveys;Testing;therapeutic target;Time;Tissue Sample;tool;Traction;Training;Translating;Translational Research;translational study;tumor;tumor progression;Universities;Update;user-friendly;Vaccine Clinical Trial;Vaccines;Variant;whole genome;Work;Zoo Animals

PROJECT_TITLE: Administrative Supplement - Leveraging Mammalian Cancers, Platinum-Quality Genome Assemblies, and Large-Scale Data to Identify Mechanisms of Rare Human Cancers

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Kidney Disease;Organ Transplantation;Prevention;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: BRENNAN, DANIEL CONLON;FISHER, CYNTHIA E;LIMAYE, ABHIJIT PRAKASH (contact)

PROGRAM_OFFICER_NAME: GALIVO, FEORILLO HERRERA

PROJECT_TERMS: Acute;Adherence;Adult;allograft rejection;Allografting;Anti-viral Agents;Anti-viral Therapy;antigen-specific T cells;Antigens;Antithymoglobulin;arm;Biopsy;CD8-Positive T-Lymphocytes;Clinical;clinical practice;Clinical Trials;Color;combinatorial;Complex;cost;Cytomegalovirus;Cytomegalovirus Infections;Data;Development;Disease;disorder prevention;evidence base;experience;Failure;Flow Cytometry;follow-up;Future;Goals;Graft Rejection;high risk;Immune;Immune response;Immunity;Immunologics;Immunology;Immunosuppression;Impairment;improved;Incidence;Infection;innovation;insight;Kidney Transplantation;liver transplantation;Logistics;Mediating;Monitor;Morbidity - disease rate;mortality;Natural Killer Cells;neutralizing antibody;novel;Organ;Outcome;Patients;permissiveness;Pharmaceutical Preparations;post-transplant;Prevention;Prevention strategy;Preventive;primary endpoint;Prophylactic treatment;Protocols documentation;Randomized;randomized, clinical trials;Regimen;Research Personnel;response;secondary endpoint;seropositive;Site;Standardization;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;Therapeutic;Time;Toxic effect;transmission process;Transplant Recipients;Uncertainty;Valganciclovir;Viral;Viremia;Virus Replication

PROJECT_TITLE: Kidney transplant Preemptive therapy or Prophylaxis (KPoP) for CMV Preventionin D+R- Recipients

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SAS-M (M1)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Aging;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Rehabilitation;Social Determinants of Health;Urologic Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This study addresses the worldwide escalating burden of Parkinson’s disease (PD) by characterizing the molecular, cellular, and network-wide mechanisms of deep brain stimulation of the subthalamic nucleus (STN DBS) in PD. This will not only expand our fundamental understanding of the intricate connections between α- synuclein aggregation, neuroinflammation, and senescence in PD but will also offer a transformative avenue to enhance health and mitigate progression of this debilitating disorder. Using rigorous translational investigations, this study will apply innovative DBS interventions to potentially reduce disability and lengthen lives.

PI_NAMEs: GAROVIC, VESNA D (contact)

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: Acceleration;Address;Adopted;Advocate;Affect;Age;alpha synuclein;Animal Experimentation;Antisense Oligonucleotides;Area;Attenuated;base;Basic Science;Behavior;behavior test;Biochemical;Bioinformatics;Biological Assay;Bradykinesia;brain circuitry;Caring;Cell Aging;Cells;Characteristics;Chronic;Classification;Clinic;Clinical;clinical application;clinical center;clinical efficacy;Clinical Research;Clinical Sciences;Clinical Skills;Clinical Trials;Communities;Competence;Complement;Complex;cost;COVID-19 pandemic;Data;Deep Brain Stimulation;Dementia;Deterioration;Diagnosis;digital health;disability;Disease;disease phenotype;Disease Progression;dopaminergic neuron;early detection biomarkers;Early Diagnosis;Education;Electric Stimulation;Elements;Environment;equity, diversity, and inclusion;Evolution;Excision;falls;FDA approved;Financial Hardship;Functional disorder;Funding;Goals;Hallucinations;Health;health care service organization;health equity;health equity promotion;health inequalities;Health system;Healthcare;Histologic;Human;Immunization;Impaired cognition;Impairment;improved;In Vitro;Income;Incubators;Inflammation;Inflammatory;inflammatory marker;Informatics;innovation;Institution;Interdisciplinary Study;Intervention;Investments;Knowledge;Leadership;member;Mentorship;Metabolic;Methods;Microglia;Mission;Modeling;Molecular;Molecular Biology;Motor;motor symptom;Movement;multidisciplinary;Muscle Rigidity;neglect;Nerve Degeneration;Neuroblastoma;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;neuroprotection;neuroregulation;Neurosciences;Newly Diagnosed;novel;operation;Operative Surgical Procedures;overexpression;Oxidative Stress;Parkinson Disease;parkinsonian rodent;Pathway interactions;Patient Care;Patients;Persons;Phenotype;Positioning Attribute;posture instability;Prevalence;prevent;Process;programs;protein aggregation;Quality of life;Radiation;Rattus;Recurrence;reduce symptoms;Research;response;Rural Population;Safety;senescence;senescent cell;single-cell RNA sequencing;skills;Social Interaction;STN stimulation;Structure;System;Talents;Testing;Therapeutic;Training;transcriptomics;translational approach;translational framework;Translational Research;translational research program;Translations;treatment optimization;Tremor;underserved community;United States;United States National Institutes of Health;Urinary Incontinence;Urinary Retention;Vision;Work

PROJECT_TITLE: Mayo Clinic Center for Clinical and Translational Science (CCaTS)


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Effects of Indoor Air Pollution;Lung;Precision Medicine

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Clinical trial of omalizumab for allergen sensitized and exposed individuals with COPD (COPD OMA) is a multi- center phase II randomized, masked, placebo-controlled clinical trial that tests the efficacy of omalizumab in improving risk for exacerbations, disease status, and lung function among individuals with COPD having sensitization with exposure to common indoor allergens. If efficacious, this study will be impactful in demonstrating allergic sensitization and exposure as a treatable trait among individuals with COPD with high risk for adverse outcomes for whom novel treatment strategies are greatly needed. Additionally, this study will provide insight into relevant biologic endotypes associated with increased responsiveness to treatment using molecular signatures of airway inflammation.

PI_NAMEs: HANSEL, NADIA N;PUTCHA, NIRUPAMA  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Acute;Adoption;Adrenal Cortex Hormones;Adult;adverse outcome;Affect;airborne allergen;airway epithelium;airway inflammation;Allergens;Allergic;Allergic Disease;American Lung Association;Asthma;Biological;Biological Assay;Biological Markers;Biological Products;Blood;Cause of Death;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Research;Clinical Trials;clinically relevant;clinically significant;Conduct Clinical Trials;Controlled Clinical Trials;cytokine;Data;Disease;efficacy evaluation;efficacy testing;Enrollment;eosinophil;Epithelial Cells;experience;Exposure to;Extrinsic asthma;Future;Gene Expression;Genetic Markers;genetic signature;Goals;Health Expenditures;high risk;Home;IgE;IgE Receptors;IL17 gene;Immune response;Impairment;improved;improved outcome;Individual;indoor allergen;Inflammation;Infrastructure;Inhalation;Injections;insight;interest;Interleukin-13;Interleukin-4;Lung;Masks;Measures;Mediating;Molecular Profiling;Morbidity - disease rate;mortality;Nasal Epithelium;novel;omalizumab;Outcome;Phase;Phase II Clinical Trials;phase II trial;Phenotype;Placebo Control;Placebos;Population;Population Heterogeneity;precision medicine;Prevalence;primary outcome;Publishing;pulmonary function;Questionnaires;Randomized;randomized placebo-controlled clinical trial;randomized, clinical trials;respiratory;Respiratory Disease;response;Risk;Sampling;secondary outcome;Signal Transduction;Subgroup;targeted treatment;Testing;trait;transcriptome sequencing;treatment group;treatment response;treatment strategy;Variant

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LP-I (M1)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: IRVINE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative The proposed research is relevant to public health because it aims to uncover novel points of intervention for future drug development. Regulatory mechanisms for RGS protein function represent a largely untapped area of investigation for the purpose of uncovering more druggable targeting strategies than the RGS proteins themselves. Thus, this research is relevant to the mission of the NIGMS because it provides basic research that increases our understanding of biological processes and lays the foundation for advances in disease treatment and prevention.

PI_NAMEs: SJOGREN, BENITA JENNY (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Area;Arteries;Asthma;Basic Science;Binding;Binding Proteins;Biochemical;Biological Assay;Biological Process;Cardiac Myocytes;Cell Line;Cells;Clinical;Complex;constriction;CUL1 gene;Cullin Proteins;Disease;DNA Damage;drug development;drug discovery;Drug Targeting;druggable target;Epigenetic Process;Event;F Box Domain;Family;Foundations;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gel electrophoresis;Genetic Transcription;Goals;GTP-Binding Proteins;GTPase-Activating Proteins;Heart failure;Heterotrimeric G Protein Subunit;Hypertension;In Vitro;in vivo;Intervention;Intracellular Signaling Proteins;Investigation;Mass Spectrum Analysis;Mediating;member;Mission;Modeling;Molecular;National Institute of General Medical Sciences;Nature;novel;Outcome Study;Pathology;pharmacologic;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Play;Post-Translational Regulation;Prevention;protein activation;protein degradation;protein expression;protein function;Protein Kinase C;protein protein interaction;Proteins;Public Health;Recombinants;Regulation;Research;Resistance;respiratory smooth muscle;response;RGS Proteins;Role;Signal Transduction;Signaling Protein;small molecule;Smooth Muscle Myocytes;Specificity;Spottings;src-Family Kinases;Stimulus;System;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Transfection;Ubiquitin-Proteasomal Pathway;ubiquitin-protein ligase;Up-Regulation;Vascular Smooth Muscle

PROJECT_TITLE: Posttranslational regulation of Regularo of G protein Signaling 2 (RGS2)

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The Yale OAIC will promote the functional independence of older Americans by increasing scientific knowledge related to multifactorial geriatric conditions, by advancing the science of clinical decision making in multimorbid older persons, by educating and training early-stage investigators in aging research from a multifactorial perspective, and by developing and implementing innovative methods that will facilitate rigorous and high impact research on multifactorial geriatric conditions.

PI_NAMEs: GILL, THOMAS MICHAEL (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TITLE: Multi-omics study of cognition in and factors for exceptional longevity


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: End stage disease of the kidneys, heart, lungs, or liver shorten the lives of veterans and solid organ transplantation of these organs is life saving. Transplantation requires life-long medications that reduce the function of the recipients’ immune systems. These medications are needed to keep the recipient from rejecting and losing the transplant, but also cause several complications including what are termed opportunistic infections. Cytomegalovirus or CMV is a virus that 60-70% of the population is infected with at a young age and is never cleared, but rather is kept in check throughout life by an active immune system. In settings of reduced immune system such as after transplant, CMV can recur resulting in illness including loss of the transplant or even death. Even when suppressed, CMV has profound effects on the immune system. This proposal seeks to better understand both the immune response to CMV and alterations to the immune system caused by CMV in veteran transplant recipients with the eventual goal of improving the lives of these patients.

PI_NAMEs: MALTZMAN, JONATHAN S (contact)

PROJECT_TERMS: Acceleration;Adult;Age;age acceleration;age related;Aging;Antibody Response;B-Lymphocytes;Caring;CD8-Positive T-Lymphocytes;Cell Compartmentation;Cessation of life;Chronic;COVID-19 booster;COVID-19 vaccination;Cytomegalovirus;Data;design;End stage renal failure;experience;experimental study;Goals;Heart Diseases;Immune;Immune response;Immune system;Immunocompromised Host;immunosenescence;Immunosuppression;improved;Individual;Infection;Inflammation;Kidney Transplantation;Knowledge;Latent virus infection phase;Life;Liver diseases;Lung Diseases;military veteran;Morbidity - disease rate;Older Population;Opportunistic Infections;Organ;Organ Transplantation;Patients;Pharmaceutical Preparations;Phenotype;Physicians;Population;post-transplant;Productivity;Recurrence;Regimen;response;Risk;Scientist;Secondary Immunization;seropositive;Shapes;Solid;T-Lymphocyte;Testing;transplant centers;Transplant Recipients;Transplantation;United States;Vaccination;Vaccines;Veterans;Virus;Virus Diseases;Work

PROJECT_TITLE: Immune control of chronic viral infection in solid organ transplantation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 IMMA-G (01)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Sexually Transmitted Infections

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: —Since 1993, the University of Washington’s annual Principles of STI/HIV Research and Public Health Practice Course has provided participants with a state-of-the-art intensive, interdisciplinary, two-week introduction to the fundamentals of behavioral, clinical, epidemiologic, statistical, implementation, and basic science research and practice in HIV and sexually transmitted infections (STI). The course is designed to increase success in identifying important knowledge gaps, asking impactful research questions, procuring research funding, and establishing cross-disciplinary research collaborations in the field of STI and HIV/AIDS.

PI_NAMEs: KHOSROPOUR, CHRISTINE MITRA (contact);PINTYE, JILLIAN

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TERMS: Academia;Active Learning;Affect;Applied Research;Area;Basic Science;Behavioral;Biological;career;Career Choice;career development;career networking;Clinical;Collaborations;community engagement;community organizations;Country;COVID-19 pandemic;Data;Data Analyses;Data Collection;design;Device or Instrument Development;Discipline;Disparity;Doctor of Philosophy;Educational Curriculum;Educational process of instructing;Effectiveness;Ensure;Environment;Epidemic;Epidemiology;Equity;Ethics;ethnic minority;evidence base;experience;Faculty;Feedback;field trip;Fogarty International Center;Fostering;fundamental research;Funding;Goals;Government;Grant;HIV;HIV/AIDS;Immunology;implementation science;Infection;Infection Control;Institution;interdisciplinary approach;Interdisciplinary Education;Interdisciplinary Study;International;Knowledge;Language;Learning;lectures;Location;marginalized population;Mentors;Methodology;Methods;multidisciplinary;National Institute of Allergy and Infectious Disease;next generation;Participant;pathogen;Pathogenesis;pedagogical content;pedagogy;peer;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Program Evaluation;programs;Public Health;Public Health Practice;public health relevance;Publishing;racial minority;Recommendation;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Technics;Research Training;Resources;response;Scientist;Sexually Transmitted Diseases;skills;Slide;social;Social Interaction;Social Network;sound;success;symposium;Techniques;Time;tool;Training;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;Update;virtual;virtual platform;Washington;web site;Woman

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: LGBT Veterans have faced a long history of stigma, discrimination, and exclusionary policies that were intended to exclude them from military service. Despite recent shifts in policy and increased staff trainings, existing evidence suggests that this group is at high risk for health disparities, particularly with respect to mental health and health risk behaviors. While informative, the research to date has been limited in several respects: cross-sectional designs, collapsing LGBT subgroups, severe lack of data on some subgroups, problems with identifying a comparison group, and lack of data on risk and protective factors and care experiences. This prospective cohort study will fill these gaps, recruiting and conducting surveys online with 1,600 Veterans to identify health disparities, test a conceptual model of prospective risk and protective factors, and assess VA utilization, barriers to care, and treatment preferences. Data from this study will inform future intervention efforts to achieve health equity for LGBT Veterans.

PI_NAMEs: SIMPSON, TRACY L. (contact)

PROJECT_TERMS: Address;Adult;Advertisements;Alcohol consumption;alcohol misuse;American Medical Association;Anxiety;barrier to care;behavioral health intervention;Bisexual;care preference;care systems;Caring;Chronic stress;Clinical Competence;Communities;comparison group;Consultations;Data;Data Collection;design;Discrimination;Disparity;Employee;Equity;Exclusion;experience;Feeling suicidal;Future;Gays;gender difference;Gender Identity;General Population;Geographic Locations;Health;health care service utilization;health disparity;health equity;Healthcare;Heavy Drinking;Heterosexuals;High Prevalence;high risk;Homophobia;improved;Individual;infancy;Institute of Medicine (U.S.);Intervention;Journals;Knowledge;Lesbian;Lesbian Gay Bisexual;Lesbian Gay Bisexual Transgender;LGBT Health;Literature;longitudinal design;Longitudinal Studies;Maps;Measures;member;men;Mental Depression;Mental Health;Methods;Military Personnel;military service;military trauma;military veteran;Minority;Minority Groups;minority stress;minority stressor;Modeling;National Health Interview Survey;Outcome;outreach;Patient Care;peer;Persons;Policies;Population;Post-Traumatic Stress Disorders;preference;Prevention;programs;prospective;Prospective, cohort study;protective factors;Provider;psychological distress;Recording of previous events;recruit;Reporting;Research;Resource Allocation;Risk;Risk Behaviors;Risk Factors;Self Medication;Services;Sex Orientation;sexual identity;Site;Smoking;social networking website;social stigma;Social support;Source;Stigmatization;Strategic Planning;stressor;Subgroup;suicidal risk;Suicide attempt;Surveys;systematic review;Testing;theories;Time;Training;transgender;transgender men;transgender women;transphobia;Veterans;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Understanding Mental Health Problems and Health Risk Behaviors among LGBT Veterans

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

PHR: PROJECT NARRATIVE Veterans with diabetes are more likely than diabetic civilians to develop chronic disabling peripheral neuropathic pain (CDNP). Research on frontline treatments for CDNP (enhanced glycemic control, exercise, pharmacological agents), shows inconsistent outcomes and dissatisfaction among Veterans. Veterans and clinicians have shown significant interest in cannabis derivatives (THC, CBD) for neuropathic pain control, but there are no well-controlled trials guiding expectations for benefit and adverse outcomes associated with cannabis for CDNP. Because Veterans are likely to present with pain and pain-related polymorbidity significant differing from that of civilians, a well-structured clinical trial of cannabinoids for Veterans with CDNP is vital. The present study will offer the first evidence describing the potential benefits and adverse effects of cannabinoids for CDNP in Veterans using a four-arm, double-blind, multisite randomized trial comparing THC, CBD, THC+CBD and placebo on neuropathic pain outcomes.

PI_NAMEs: D'SOUZA, DEEPAK CYRIL (contact);MCGEARY, DONALD DOUGLAS

PROJECT_TERMS: abuse liability;active method;Adherence;Adult;Adverse effects;Adverse event;adverse outcome;Affect;antinociception;Anxiety;arm;associated symptom;Benefits and Risks;Biological Markers;Cannabidiol;Cannabinoids;Cannabis;cannabis withdrawal;Cellular Phone;Chronic;chronic pain;Clinical Research;Clinical Trials;cognitive function;Collaborations;comorbidity;Complications of Diabetes Mellitus;Controlled Study;cooperative study;daily pain;Data;Dependence;design;Diabetes Mellitus;diabetic;diabetic patient;diagnostic criteria;diaries;disability;Disabling;Disabling condition;Dose;Double-Blind Method;duloxetine;efficacy evaluation;emotional functioning;Enrollment;Exercise;expectation;fall risk;Fatigue;four-arm study;General Population;glycemic control;Health Care Costs;health related quality of life;high risk;Human;improved;Individual;Insulin;Intention;interest;Intervention;intervention effect;Lead;Linear Regressions;marijuana use;marijuana use disorder;marijuana user;Measures;Mediating;Medical Marijuana;medication compliance;Mental Depression;Methods;Modeling;Monitor;non-opioid analgesic;Numeric Rating Scale;opioid epidemic;opioid use;Outcome;Outcome Measure;Outcomes Research;Pain;Pain management;Pain Measurement;pain outcome;Pain quality;pain reduction;pain relief;Pain Research;pain scale;pain score;pain-related disability;painful neuropathy;Participant;Patients;Peripheral;Peripheral Nervous System Diseases;pharmacologic;Pharmacotherapy;Pharmacy facility;Phase;phase 2 study;phase III trial;pill;Placebo Control;Placebos;Post-Traumatic Stress Disorders;preclinical study;pregabalin;primary outcome;programs;Protocols documentation;psychiatric comorbidity;Quality of life;Randomized;Randomized Controlled Clinical Trials;randomized trial;recruit;Reporting;Research;Research Personnel;Risk;Safety;safety outcomes;Sampling;satisfaction;secondary analysis;secondary outcome;Serious Adverse Event;side effect;Single-Blind Study;Site;Sleeplessness;Standardization;Statistical Models;Structure;substance use;Surveys;synthetic cannabinoid;Tachycardia;Tapentadol;Tetrahydrocannabinol;Therapeutic;Titrations;Traumatic Brain Injury;treatment adherence;treatment arm;Treatment Cost;Treatment Efficacy;Treatment outcome;trial comparing;United States;United States Department of Veterans Affairs;urinary;vehicular accident;Veterans;Withdrawal Symptom;Work

PROJECT_TITLE: Proof of Concept Trial of Cannabis Derivatives in Neuropathic Pain.


ORG_CITY: KANSAS CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: RELEVANCE TO PUBLIC HEALTH Bladder cancer is a tumor associated with aging. We have hypothesized this is due to increased inflammation that drives cancer formation and progression in aged patients or aged animals and that this may be related to age associated alterations in the gut microbiota. We hope to reduce this inflammation through direct interventions against neutrophils or through microbial transplantation.

PI_NAMEs: WOOLBRIGHT, BENJAMIN LELAND (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: 16S ribosomal RNA sequencing;Affect;age related;age related changes;aged;Aging;aging mechanism;aging related;aging related disease;animal old age;Animals;Antibiotics;Back;beta diversity;Biological Assay;Biology;Bladder;Blood;Breast;Cancer Model;Carcinogens;career;CD8B1 gene;cell injury;Cell Proliferation;Cells;chemotherapy;Chronic;Collaborations;Colon;Combined Modality Therapy;comorbidity;comparative;Credentialing;cytokine;Data;Dedications;Deposition;Development;Dextrans;Diagnosis;Disease;DNA;DNA Damage;Education;Elderly;Excision;Exposure to;fecal microbiome;fecal transplantation;Feces;Fluorescein-5-isothiocyanate;Functional disorder;Future;Genetic;Genetic Models;gut bacteria;gut health;gut homeostasis;gut microbiome;gut microbiota;Immune;Immune system;Immunotherapy;improved;Incidence;indexing;Inflammaging;Inflammation;Inflammatory;inhibitor;Innate Immune System;Interleukin-8B Receptor;Intervention;intervention effect;Intestinal permeability;juvenile animal;K22 Award;Leadership;Life;Link;lipopolysaccharide-binding protein;Lipopolysaccharides;Liver;Macrophage;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Mediating;microbial;microbiome;microbiota;Modeling;Monitor;monocyte;mouse model;Mus;neutrophil;Neutrophil Activation;Neutrophil Infiltration;Nitrosamines;novel;old mice;older patient;Operative Surgical Procedures;Outcome;Oxidases;pathogen;Patients;pharmacologic;Phenotype;Plasma;Population;prevent;Principal Component Analysis;Production;Public Health;Reactive Oxygen Species;recruit;Recurrence;Regulatory T-Lymphocyte;Research;Resolution;Risk;risk stratification;Role;Scientist;Signal Transduction;Solid Neoplasm;standard of care;Time;tissue injury;Tissues;Translations;Transplantation;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor stage;Tumor Volume;tumorigenesis;tumorigenic;Weight

PROJECT_TITLE: Role of Gut-Immune Interactions in Aging-Associated Bladder Cancer


FUNDING_MECHANISM: OTHERS

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Inflammatory bowel disease has one of the highest hospitalization rates among veterans (>100,000 hospitalizations from 1975-2006). Current therapies primarily involve systemic immune suppression. This carries certain risks, including an increased risk of infection and malignancy. The risks are more significant with increasing age, duration of use and in patients who require a combination of drugs for disease control. Additionally, many patients do not respond to available therapies and the costs of many options are significant. The veteran population includes a substantial proportion of older patients susceptible to these risks, as well as young patients who may have to be on these medications long term. To address these problems, novel and safer therapeutic strategies are needed. This project is designed to evaluate the therapeutic potential of targeted activation of two important homeostatic pathways using novel approaches that can be harnessed to characterize and translate the potential of other mucosal homeostatic pathways.

PI_NAMEs: ONYIAH, JOSEPH  (contact)

PROJECT_TERMS: Address;Adoptive Transfer;Age;Animal Model;Anti-Inflammatory Agents;Award;bHLH-PAS factor HLF;Biliverdine;Biochemical;Biological;Biology;Bone Marrow;Carbon Monoxide;career development;Cells;chemokine;Chronic;Clinical;Colitis;Complex;cost;cytokine;Cytoprotection;Data;defined contribution;design;Development;dimer;Disease;disorder control;Drug Combinations;efficacy testing;Enteral;Enzymes;Epithelial Cells;Epithelium;Equilibrium;experience;Funding;Gastroenterologist;gene repression;gut inflammation;Heme;heme oxygenase-1;Homeostasis;Hospitalization;hospitalization rates;Human;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Immunosuppression;improved;infection risk;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Institution;interest;Interleukin-10;intestinal epithelium;Intestinal Mucosa;Iron;Knock-out;Link;Macrophage;Malignant Neoplasms;Measures;Mentors;Metabolic;military veteran;Modeling;mouse model;Mucosal Immune System;Mucositis;Mucous Membrane;murine colitis;Mus;Myelogenous;novel;novel strategies;older patient;Oxidative Stress;Oxygen;Pathway interactions;Patients;Pharmaceutical Preparations;Physicians;Predisposition;Procollagen-Proline Dioxygenase;Protein Isoforms;Regulation;Research;response;Risk;Role;Scientist;Signal Transduction;Stimulus;Stress;Structure;Testing;Therapeutic;therapeutic target;Time;Tissues;Training;Transcription Coactivator;transcription factor;Translating;Translations;Veterans

PROJECT_TITLE: Therapeutic Potential of Targeted Mucosal Heme Oxygenase-1 in Colitis


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE PATH is an innovative intervention that builds on years of strong theoretical, experimental, and clinical work to target key interconnected maladaptive (unproductive processing, avoidance, and impaired reward sensitivity) and adaptive processes (updating/reappraisal, approach, and positive affect) related to persistent, stressful life event-related psychopathology (e.g., depression, posttraumatic stress disorder). This brief 6 session intervention focuses on processing of negative destabilizing life events, positive life events, and future events. It has the potential to enhance treatment engagement and outcome, build resilience, prevent relapse, and ultimately to reduce the substantial and costly burden of stressor-related psychopathology.

PI_NAMEs: FEENY, NORAH C (contact);HAYES, ADELE ;ZOELLNER, LORI A

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: Adherence;Affect;burden of illness;Chard;Clinical;coping;cost;debilitating symptom;depressive symptoms;Diagnostic;Disease;Distress;Dose;Dropout;Economic Burden;Educational process of instructing;Emotional;Emotions;Environment;Etiology;Event;evidence base;experience;experimental study;Exposure to;Feedback;follow-up;Future;Health;Human;Impairment;improved;Individual;innovation;Intervention;Job loss;Left;Life;Link;loved ones;Measures;Mental Depression;Minority;Minority Groups;Modeling;Muscle relaxation phase;National Institute of Mental Health;negative mood;Negative Valence;novel;Outcome;Pathologic;Patients;Population;positive emotional state;Positive Valence;Post-Traumatic Stress Disorders;Prevalence;Process;promote resilience;Prospective Studies;psychologic;Psychopathology;Psychotherapy;Randomized;randomized trial;Randomized, Controlled Trials;Relapse;relapse prevention;relapse risk;Research;resilience;reward processing;Rewards;Risk;Role;rumination;Sampling;sexual assault;skills;Strategic Planning;Stress;Stressful Event;stressor;Symptoms;System;Taxes;Therapeutic;therapeutic target;Time;Update;Visit;Work

PROJECT_TITLE: Treatment of Stress-Related Psychopathology: Targeting Maladaptive and Adaptive Event Processing


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative  Small vessel disease can contribute significantly to cognitive impairment and dementia. This project will conduct multi-site clinical validation of 4 image-based and 2 fluid-based biomarkers, so that they are ready for future clinical trials, including large phase III trials, of vascular cognitive impairment and dementia (VCID).

PI_NAMEs: ALBERT, MARILYN S.;LU, HANZHANG  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: African American;Alzheimer's Disease;Asian population;Biological;Biological Markers;biomarker selection;biomarker validation;Blood;Blood Vessels;candidate marker;Caucasians;cerebrovascular reactivity;Clinical;clinical research site;Clinical Trials;Cognitive;cohort;computerized data processing;Consensus;Data;Data Analyses;data sharing;Dementia;Diabetes Mellitus;Enrollment;Equipment;Event;experience;flexibility;follow up assessment;follow-up;Functional Imaging;Funding;Future;Goals;Hispanic;human subject;hypercholesterolemia;Hypertension;Image;imaging biomarker;Impaired cognition;indexing;Lead;Liquid substance;Longitudinal cohort study;Longitudinal Studies;Magnetic Resonance Imaging;Manuscripts;Measures;meetings;Memory;Microvascular Dysfunction;mild cognitive impairment;Mission;National Institute of Neurological Disorders and Stroke;neuroimaging;Neuropsychology;Obesity;Older Population;Paper;Participant;participant enrollment;participant retention;Persons;Phase;phase III trial;Procedures;Process;Protocols documentation;Quality Control;recruit;Research;Research Personnel;Site;Smoking;Source;Standardization;symposium;Testing;Training;treatment center;United States;Validation;vascular cognitive impairment and dementia;vascular risk factor;Work

PROJECT_TITLE: Validation of small vessel vascular contributions to cognitive impairment and dementia (VCID) biomarkers


ORG_CITY: NEW YORK

ORG_NAME: VA  MEDICAL CENTER

ORG_STATE: NY

PHR: Heart disease remains the leading cause of death in Veterans. Inflammation in the arteries of the heart may increase the risk of cardiac death. Patients with heart disease undergoing major surgery are at increased risk of complications after surgery, including heart attack, stroke, and death. The proposed research seeks to better understand the role of inflammation in the damage to the heart and blood vessels after major surgery. This research also seeks to identify the potential beneficial role of a safe medication, colchicine, which has direct effects on inflammatory cells and has been used in the treatment of inflammatory diseases for more than 2000 years, on reducing the rate of complications after surgery. With its quick onset of action and excellent safety profile, colchicine may have the potential to reduce risk of heart injury, stroke, or death after major surgery.

PI_NAMEs: SHAH, BINITA  (contact)

PROJECT_TERMS: ABCB1 gene;Acute;Adhesions;American Heart Association;Anesthesia procedures;Anti-Inflammatory Agents;Biological Markers;Blood Platelets;Blood Vessels;C-reactive protein;Cardiac Death;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cell Adhesion Molecules;Cells;Cessation of life;Chemotaxis;Chemotaxis Inhibition;Clinical;clinical predictors;Code;Colchicine;Consensus;Coronary;Coronary Arteriosclerosis;Coronary artery;cost effective;cost effective treatment;cytokine;Data;Development;Disease;Dose;Double-Blind Method;endothelial dysfunction;Endothelium;Event;extracellular;Extravasation;Fluid Shifts;Fostering;Funding;gastrointestinal;Generations;Genetic;Genetic Polymorphism;genetic predictors;Heart;Heart Diseases;Heart Injuries;hemodynamics;Heterogeneity;high risk;Hospitalization;Hospitals;Hour;Immune;Immunosuppression;Impairment;improved;Incidence;Inflammasome;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;injured;Injury;insight;Interleukin-1 beta;Interleukin-6;Interruption;Intervention Trial;Lipids;Macrophage;Measures;Mediating;Medical;Membrane Glycoproteins;migration;Multi-Drug Resistance;Myocardial Infarction;myocardial injury;Myocardial Ischemia;neutrophil;novel therapeutic intervention;operation;Operative Surgical Procedures;Outcome;patient subsets;Patients;Peptide Hydrolases;percutaneous coronary intervention;Perioperative;perioperative mortality;Peripheral;Peripheral arterial disease;personalized medicine;Pharmaceutical Preparations;Pharmacogenetics;Phenotype;Placebos;Platelet aggregation;Play;Population;Postoperative Period;Predictive Factor;Production;Proteomics;Randomized;randomized trial;Research;Research Design;resistance gene;responders and non-responders;response;revascularization;Risk;Risk Reduction;Role;Rupture;Safety;Secondary Prevention;Site;Stroke;Surface;systemic inflammatory response;targeted treatment;Testing;Therapeutic Effect;Thrombophilia;Thrombosis;thrombotic;Time;treatment response;United States;uptake;vascular inflammation;vascular injury;Vasculitis;Veterans;wound healing

PROJECT_TITLE: Impact of Colchicine on Peri-Operative Major Adverse Cardiovascular Events in Patients with Prior Coronary Revascularization


ORG_CITY: MADISON

ORG_NAME: WM S. MIDDLETON MEMORIAL VETERANS HOSP

PHR: Prostate cancer is a disease with a remarkably high impact on Veteran health. Not only is it the most common cancer diagnosed in Veterans, with nearly 15,000 new cases diagnosed each year, but Veteran men get diagnosed with prostate cancer at nearly twice the rate of the general population. Unfortunately, even with treatment, many of these Veterans will eventually die from their prostate cancer. New, effective prostate cancer treatments are therefore desperately needed. While this research begins in the lab, current laboratory research models do a notoriously poor job of identifying therapies that will be effective in patients. We have therefore developed a new cell culture platform, called Stacks, that enables improved modeling of patient tumors in the lab using their own cells. Our primary objective in the proposal will be to determine whether the Stacks platform can better mirror the biology inside patient tumors and more accurately predict the effectiveness of prostate cancer therapies in Veteran men with metastatic prostate cancer than currently available platforms.

PI_NAMEs: KOSOFF, DAVID  (contact)

PROJECT_TERMS: Address;Animal Model;Animals;anti-cancer research;Area;Biological;Biological Models;Biology;cancer diagnosis;Cancer Patient;cancer therapy;Caring;Cell Count;Cell Culture Techniques;Cell Line;cell type;Cells;Clinical;clinical efficacy;clinical predictors;clinical translation;Clinical Trials;clinically relevant;Coculture Techniques;cytotoxic;Data;Data Set;Development;Diagnosis;Disease;docetaxel;drug development;effective therapy;Effectiveness;efficacy evaluation;Evaluation;Exhibits;Fibroblasts;Gene Expression;Gene Expression Profile;General Population;Health;Heterogeneity;Immunosuppression;improved;improved outcome;In Vitro;in vitro Model;Information Systems;insight;Investigation;Investments;Laboratory Research;Macrophage;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metastatic Prostate Cancer;Microfluidics;Modeling;Molecular;monocyte;mouse model;neoplastic cell;novel;Occupations;Organoids;Patients;Phenotype;physiologic model;Physiology;Population;pre-clinical;Pre-Clinical Model;pre-clinical research;pre-clinical therapy;Prediction of Response to Therapy;prostate cancer cell;Prostate Cancer therapy;Research;response;Role;Signal Transduction;System;Testing;Therapeutic;therapy development;Time;tool;transcriptome sequencing;treatment comparison;treatment effect;Treatment Efficacy;treatment response;tumor;Tumor Biology;Tumor Cell Line;tumor microenvironment;Veterans

PROJECT_TITLE: Evaluation of novel microscale cell culture platform for translational drug development in prostate cancer


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Clinical Research;Genetics;Prevention;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Narrative Breast cancer is the most common cancer and the second most common cause of death in women. Lack of mechanistic understanding on how a breast cancer in situ develops into malignant invasive breast cancer contributes to growing problem of both overtreatment and undertreatment. To address this, we propose to develop three-dimensional organoid model using cell lines and primary patient-derived cells. Based on existing studies and our own preliminary studies, we hypothesize that organoid size-induced hypoxia and secretome factors work cooperatively to initiate and maintain the migratory phenotype. We will use integrated bioengineering, computational and imaging approaches to test this hypothesis and discover novel druggable targets to stop emergence of migratory phenotype.

PI_NAMEs: SANT, SHILPA  (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: 3-Dimensional;Address;Agreement;AKT Signaling Pathway;Antitumor Response;Award;Biomedical Engineering;Breast Cancer Detection;Breast Cancer Patient;breast cancer progression;Cancer cell line;Carcinoma in Situ;Cause of Death;CCL2 gene;Cell Line;Cell secretion;Cells;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;confocal imaging;Coupled;CXCL10 gene;CXCR3 gene;cytokine;deep learning;deep learning algorithm;design;Development;Diagnosis;Drug Screening;Duct (organ) structure;E-Cadherin;effective therapy;Engineering;Environment;Epidermal Growth Factor Receptor;Exhibits;Experimental Models;Fibronectins;gene regulatory network;Genetic;genetic signature;genomic profiles;Heterogeneity;Hybrids;Hypoxia;IL7 gene;IL8 gene;Image Analysis;imaging approach;improved;In Vitro;in vitro Model;in vivo;Individual;infiltrating duct carcinoma;innovation;Interleukin-10;Interleukin-15;Interleukin-6;Invaded;Knock-in;Knowledge;Label;Lead;Left;Link;Maintenance;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Matrix Metalloproteinases;Metabolic stress;Metastatic breast cancer;meter;Micro Array Data;Microarray Analysis;migration;Modeling;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Noninfiltrating Intraductal Carcinoma;novel;Organoids;Outcome;overtreatment;paracrine;Parents;Pathway interactions;Patients;Peripheral;Phenotype;PI3K/AKT;PIK3CG gene;Pleural;Pleural effusion disorder;premalignant;prevent;Prognostic Marker;progression risk;Proteins;Reproducibility;Resolution;rho GTP-Binding Proteins;risk prediction;Role;Sampling;Signal Pathway;Signal Transduction;Site;Sorting;Spatial Distribution;Stimulus;Stress;Structure;System;Testing;Therapeutic;therapy development;Time;treatment strategy;tumor;tumor heterogeneity;Variant;Vimentin;Visualization;Women's mortality;Work

PROJECT_TITLE: Three-dimensional organoid models to study breast cancer progression


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative: Arthropod borne flaviviruses, such as Dengue, produce non-coding RNAs that function to benefit these viruses during infection. Specifically, these non-coding RNAs (termed sfRNAs) have been shown to be involved in pathogenicity, interferon repression, RNAi repression, along with many other functions, indicating that they are important to understand in order to better arm ourselves with potential new therapies. This study will focus on unveiling the specific coordination observed in relevant tandem xrRNA structures located within the flavivirus 3′ UTR, as well as how these sfRNAs attenuate the mosquito RNAi immune response.

PI_NAMEs: SPEAR, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: 3' Untranslated Regions;Affect;Arbovirus Infections;arm;arthropod-borne;Attenuated;Binding;Binding Sites;Biochemical;Biological Assay;Cells;Coupled;Coupling;Culicidae;Data;Dengue;Dengue Infection;Dengue Virus;Double-Stranded RNA;Down-Regulation;Elements;enzyme substrate;Exoribonucleases;Flavivirus;Flavivirus Infections;Genome;genomic RNA;Goals;Human;Immune;Immune Evasion;Immune response;Immunity;In Vitro;Infection;Interferons;Introns;Knowledge;Lead;Maps;member;Methods;mosquito-borne;Mutation;novel therapeutics;pathogen;Pathogenicity;Pattern;Persons;prevent;Production;Proteins;Recombinants;Reporter;Reporting;Repression;Research;Resistance;response;Ribonucleases;RNA;RNA Interference;RNA Interference Pathway;RNA Viruses;Series;Small Interfering RNA;Small RNA;spleen exonuclease;stem;Structure;System;Testing;Untranslated Regions;Untranslated RNA;vector;vector mosquito;viral fitness;viral genomics;Viral Physiology;Virus;Virus Diseases;West Nile virus;Western Blotting;Work;ZIKA;Zika Virus

PROJECT_TITLE: Investigating the Formation and Function of Subgenomic Flavivirus RNAs During Flavivirus Infection of the Mosquito Vector


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Mental Health

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative Domesticated animals have provided invaluable insights into biological and biomedical traits important to hu- man health, but most are not easily amenable to experimentation. Here, we propose to develop and use Sia- mese Fighting Fish, Betta splendens, as a powerful new vertebrate model system by developing genetic tools and by studying the molecular bases of anatomical diversity and the genetic and neuronal bases of their ex- treme aggressive behavior.

PI_NAMEs: BENDESKY, ANDRES  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Aggressive behavior;Anatomy;base;Behavioral;Behavioral Genetics;Biological;Biological Models;Breeding;Canis familiaris;Chromosome Mapping;Clutch Size;Color;Columbidae;Defect;Development;Dissection;DNA Resequencing;Domestic Animals;egg;Ethics;Evolution;Experimental Genetics;fighting;Fishes;Foundations;Generations;Genes;Genetic;genetic analysis;genetic manipulation;Genome;Genomics;Health;Human;Infertility;insight;interest;Laboratories;Learning;Methods;model organism;Modeling;Molecular;Morphology;neuronal circuitry;Neurons;novel;Pathway interactions;Phenotype;Physiological Adaptation;Population Genetics;Process;Quantitative Genetics;Shapes;siamese fighting fish;System;Thailand;theories;Time;tool;trait;Vertebral column;Vertebrates;whole genome;Wild Animals

PROJECT_TITLE: Pioneering Betta splendens as a new vertebrate model for evolutionary and behavioral genetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Systemic lupus erythematosus (SLE) patients suffer from heart attacks at rates well above the general population. Heart disease results in part from abnormal function of endothelial cells that prevent artery clogging cholesterol plaques from forming. Half of SLE patients also develop kidney disease that can lead to kidney failure. We propose a paradigm shift to focus on endothelial cell dysfunction as a mediator of inflammation in the kidney as well as in heart disease. Based on the results of the prior funding period, we will test the effectiveness of a medicine that restores endothelial function (sepiapterin) to treat lupus-like kidney disease and improve endothelial function in mice with lupus kidney disease. We will study its ability to prevent kidney disease, induce remission of kidney disease along with standard treatment, and maintain remission after withdrawal of the standard medication. We will study alternative ways that endothelial dysfunction occurs and how sepiapterin works to improve outcomes to inform future human studies.

PI_NAMEs: OATES, JAMES C (contact)

PROJECT_TERMS: Acceleration;Address;Adhesions;Affect;Anti-Inflammatory Agents;Antigen-Antibody Complex;Arteries;Atherosclerosis;Biological Markers;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;Cells;Chemotaxis;Cholesterol;Chronic;Clinical;Clinical Trials;Combined Modality Therapy;Couples;Coupling;cytokine;Diabetes Mellitus;Disease;Disease remission;Dose;effective therapy;effectiveness testing;Effector Cell;Endothelial Cells;endothelial dysfunction;Endothelium;Event;experience;FDA approved;Fibrosis;Flare;FOXO1A gene;Functional disorder;Funding;Future;Gene Expression;General Population;Genes;glomerular endothelium;Goals;Health;Heart Diseases;Histologic;Human;Hypertension;hypertensive;immunoregulation;improved;improved outcome;In Vitro;in vivo;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Infiltrate;Innate Immune Response;Kidney;kidney cortex;Kidney Diseases;Kidney Failure;Knowledge;Lupus;Lupus Nephritis;lupus-like;Macrophage;macrovascular disease;Mediating;Medicine;Methods;Modeling;monocyte;monomer;Mus;Mycophenolate;Myocardial Infarction;Necrosis;Nephritis;Nitric Oxide;NOS3 gene;Onset of illness;Outcome;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Pathogenicity;Pathologic;Pathway interactions;Patients;PDGFRB gene;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;PIK3CG gene;Platelet-Derived Growth Factor Receptor;podocyte;predicting response;Prevalence;prevent;Prevention;primary endpoint;Production;Publishing;Reactive Oxygen Species;Remission Induction;response biomarker;Rodent;sepiapterin;Serum;Signal Induction;Signal Transduction;single-cell RNA sequencing;Spleen;standard care;Stimulus;Superoxides;Systemic Lupus Erythematosus;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;tetrahydrobiopterin;Therapeutic;therapeutic target;therapy development;Time;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;Translating;translation to humans;treatment response;Vascular Diseases;Veterans;Withdrawal;Work

PROJECT_TITLE: Targeting Pathogenic Endothelial Dysfunction in Lupus Nephritis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Regenerative Medicine;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: AUGUSTA

ORG_DEPT: NEUROSURGERY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Intracerebral hemorrhage (ICH), the most devastating and least treatable form of stroke, is induced by a ruptured blood vessel within the brain. Unfortunately, no FDA-approved therapies currently exist to recover the extensive loss of brain function after ICH, contributing to the poor quality of life in ICH survivors. Our proposed state-of-the-art studies will determine whether remote ischemic conditioning (RIC), a simple, safe, and non- invasive therapy that involves the repetitive inflation-deflation of a blood pressure cuff on the arm, restores brain function in a pre-clinical model of ICH.

PI_NAMEs: DHANDAPANI, KRISHNAN M. (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acute;Affect;Age;American;angiogenesis;Anti-Inflammatory Agents;Architecture;arm;Arteries;arteriole;Blood capillaries;Blood Pressure;blood vessel development;Blood Vessels;Bone Marrow;Brain;Brain hemorrhage;Brain Injuries;Cells;Cerebral Amyloid Angiopathy;Cerebral hemisphere hemorrhage;Cerebral Ischemia;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Circulation;Chronic;Clinical;clinical translation;Clinical Trials;comorbidity;cost effective;Development;dietary;Drug Kinetics;endothelial stem cell;Endothelium;Essential Fatty Acids;Excision;Exercise;Exhibits;Extracellular Matrix Proteins;Fatty Acids;FDA approved;Goals;Hematoma;Human;Hypertension;Immune;improved;Inflammation;injured;innovation;Intervention;Intracranial Arterial Stenosis;Ischemia;ischemic conditioning;Ischemic Stroke;Lifelong disability;limb ischemia;Limb structure;Macrophage;Mediating;Mediator;Medical Assistance;Metabolic;mortality;Mus;Myelogenous;Myeloid Cell Activation;Myocardial Infarction;neovascularization;Nervous System Physiology;neural network;neurogenesis;Neurologic;Neurological outcome;neurological recovery;Neuroprotective Agents;neurorestoration;Nutrient;Outcome;Pathway interactions;Patients;Phase I Clinical Trials;Pre-Clinical Model;Predisposition;preservation;Production;Proteins;Quality of life;Recovery;Regulation;repaired;Research;Resolution;response;restoration;revascularization;Rupture;Safety;sex;stem cells;Stroke;Subarachnoid Hemorrhage;Survivors;targeted treatment;Testing;Therapeutic;tissue repair;Tissues;translational study;Vascular Dementia;Vascular remodeling;white matter injury

PROJECT_TITLE: Remote ischemic Conditioning Promotes Cerebrovascular Recovery after Intracerebral Hemorrhage

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: MAYWOOD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Project Narrative RNA viruses are significant, ever-evolving pathogens that cause morbidity and mortality worldwide, and therapeutic interventions are scant. Here, we propose to investigate how these viruses rely on small metabolites called polyamines for replication. We will also characterize how polyamines interconnect with other metabolic pathways, highlighting opportunities for therapeutic intervention.

PI_NAMEs: MOUNCE, BRYAN C (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Affect;Anabolism;Biological Models;Bunyavirus Infections;Cell Physiology;Cells;Cholesterol;Coxsackie Viruses;Dengue Virus;Detection;Distant;Enterovirus;Eukaryotic Cell;Family;Flavivirus;Genetic Transcription;Genome;Infection;La Crosse virus;Link;Lipids;Metabolic Pathway;Metabolism;Morbidity - disease rate;mortality;pathogen;Pathway interactions;Polyamines;Rhinovirus;Rift Valley fever virus;RNA Viruses;Role;small molecule;Structure;Therapeutic Intervention;Translations;Virion;Virus;Virus Diseases;Virus Replication;Work;Zika Virus

PROJECT_TITLE: Uncovering and harnessing connected metabolic pathways essential to virus infection.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Genetics

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: Project Narrative Retrotransposons are ancient DNA elements that self-replicate within our genome and now make up 45% of our genetic material. Expression of retrotransposons presents acute dangers to cell viability and occurs during the progression of multiple human diseases such as cancer, and chronic inflammation. This proposal aims to decipher the epigenetic defense mechanisms that silencing retrotransposon expression and to understand how dysregulation of these mechanisms occurs in disease.

PI_NAMEs: WORDEN, EVAN J (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acute;Biochemical;Cell Survival;Cells;Cellular Structures;Chronic;Code;Complex;Cryoelectron Microscopy;Defense Mechanisms;Deposition;Disease;DNA;Elements;Epigenetic Process;Genetic Code;Genetic Materials;Genome;Genomics;Goals;Heterochromatin;histone methylation;Histone-Lysine N-Methyltransferase;human disease;In Vitro;Inflammation;Innate Immune Response;Length;Malignant Neoplasms;Methylation;methylation pattern;Modification;Molecular;Nature;programs;reconstitution;recruit;Regulation;Research;Retrotransposition;Retrotransposon;Role;Work

PROJECT_TITLE: Epigenetic Mechanisms of Retrotransposon Silencing

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_DEPT: PHYSIOLOGY

PHR: Consumption or rejection of food are outcomes of a hierarchical multisensory decision-making process. Food-related decisions must frequently resolve conflicts, such as whether to consume a fruit that is visually appealing but smells rotten. Such decisions require neural substrates for evaluating characteristics of food—appearance, smell, taste, touch—and comparing/contrasting such characteristics to decide whether to approach, assess, and/or consume. Food-related decisions and their neural mechanisms are hugely important in human life, and dysfunction leads to disorders such as obesity, diabetes, and heart disease. We study food-related decision making in Drosophila melanogaster flies and Caenorhabditis elegans nematode worms, which have simpler behavioral repertoires, are highly experimentally tractable, and have proven utility at generating biological insights of relevance to mammalian model systems and human beings.

PI_NAMEs: NITABACH, MICHAEL  (contact)

PROJECT_TERMS: Animals;Appearance;Behavioral;Biological;Biological Models;Caenorhabditis elegans;Characteristics;color detection;conflict resolution;Consumption;Decision Making;detection platform;Diabetes Mellitus;Disease;Drosophila genus;Drosophila melanogaster;fly;Food;Foundations;Fruit;Functional disorder;Heart Diseases;Human;insight;Life;Mammals;Molecular;multisensory;Nematoda;neural;neuromechanism;neuroregulation;Obesity;Opsin;Outcome;Pathway interactions;Process;Research;Smell Perception;Taste Perception;Touch sensation;Visual

PROJECT_TITLE: Biological Mechanisms of Food-Related Decision Making

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]