NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Heart Disease;Neurodegenerative;Neurosciences;Nutrition;Pediatric;Physical Activity;Prevention;Rare Diseases

ORG_STATE: PA

PHR: NARRATIVE In the rare disease Friedreich’s Ataxia (FA), abnormal skeletal muscle energy production may contribute to functional decline in individuals with heart failure, which is the leading cause of premature death in this condition. We propose a mechanistic randomized controlled trial of exercise training and supplementation with nicotinamide riboside, a precursor for NAD+, a metabolite that is critical for muscle metabolism, in individuals with FA who have not yet developed heart failure but have evidence of defects in skeletal muscle energy production. Our findings will lay the groundwork for future trials to improve functional status in individuals with FA.

PI_NAMEs: MCCORMACK, SHANA ERIN (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Activities of Daily Living;Adult;advocacy organizations;Aerobic;Affect;Age;Animals;arm;Ataxia;Attenuated;Cardiomyopathies;Caring;Cessation of life;Child;clinical outcome measures;cofactor;cohort;Combined Modality Therapy;Complement;Defect;design;Diabetes Mellitus;diabetes risk;Disease Progression;Engineering;Enrollment;Ergometry;Exercise;Exercise Test;exercise training;frataxin;Friedreich Ataxia;functional decline;functional status;Future;Genes;glucose metabolism;glucose tolerance;Heart failure;heart function;high risk;Home;Immobilization;Impairment;improved;in vivo imaging;Individual;innovation;insight;Insulin;insulin sensitivity;Iron;knockout animal;Knowledge;Measures;Mediating;mimetics;Mitochondria;Mus;Muscle;muscle form;muscle metabolism;Muscle Mitochondria;Muscular Atrophy;Mutation;Myocardium;Natural History;Neurodegenerative Disorders;Nicotinamide adenine dinucleotide;nicotinamide-beta-riboside;novel strategies;OGTT;Outcome;Oxidative Phosphorylation;Participant;Pediatric Hospitals;Philadelphia;premature;Premature Mortality;preservation;primary outcome;Production;Randomized;Randomized, Controlled Trials;Rare Diseases;recruit;reduced muscle mass;Regimen;Registries;Resistance;Respiration;Respiratory Chain;Safety;sedentary;skeletal abnormality;Skeletal Muscle;skeletal muscle metabolism;stable isotope;Stimulus;Supplementation;Symptoms;Testing;translational potential;VO2max;Wasting Syndrome;young adult

PROJECT_TITLE: NAD+ precursor supplementation with exercise training to improve aerobic capacity in Friedreich's Ataxia

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Digestive Diseases;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Dysregulated immune responses are an important cause of intestinal toxicities after bone marrow transplantation (BMT), but little is known about where these immune responses occur within the intestinal tissue or how this localization may affect the stem cells maintaining the intestines. The purpose of this project is to study where cells of the immune system function within the GI tract after BMT and how their locations impact specific intestinal targets. This will lead to new biologic insights into the interactions between the immune system and the intestinal stem cell compartment, as well as the development of new therapies that can protect and promote recovery of damaged intestinal tissue after BMT.

PI_NAMEs: HANASH, ALAN M (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: 3-Dimensional;Active immunity;Acute Graft Versus Host Disease;Address;Adoptive Cell Transfers;Affect;Allogeneic Bone Marrow Transplantation;Allogenic;Automobile Driving;base;Behavior;Biological;Biology;Bone Marrow Transplantation;Cell Adhesion Molecules;Cell Communication;Cell Compartmentation;cell injury;cell motility;Cells;chemokine;Clinical;clinically significant;Coculture Techniques;conditioning;crypt cell;Development;dimer;Endothelium;Enterocytes;Environment;epithelial injury;epithelial stem cell;Epithelium;epithelium regeneration;Frequencies;Functional disorder;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal tract structure;Gene Expression;genetic manipulation;Genetic Techniques;Genetic Transcription;Goals;graft vs host disease;Hematopoietic;hematopoietic transplantation;Homeostasis;Homing;Homologous Transplantation;Human;human model;Immune;immune imaging;Immune response;Immune system;immune system function;Immune Targeting;Immunity;Immunologics;Immunology;immunopathology;Immunosuppression;In Situ;in vivo;in vivo evaluation;in vivo Model;Individual;Infiltration;Inflammatory Bowel Diseases;injury recovery;insight;interleukin-22;Intervention;intestinal injury;Intestinal Mucosa;Intestines;intravital imaging;Invaded;LGR5 gene;Ligands;Location;Lymphocyte;Lymphoid Cell;Maintenance;man;Measures;Mediating;Memorial Sloan-Kettering Cancer Center;microscopic imaging;Microscopy;migration;Modeling;Molecular;mouse model;Mucous Membrane;multidisciplinary;Natural regeneration;novel;novel therapeutics;Organoids;Paneth Cells;Pathogenicity;Pathologic;Pathology;Pathway interactions;Phenotype;Physiological;post-transplant;Process;protein expression;Publishing;Recovery;recruit;Regulation;Research Proposals;Resources;response;Role;Sampling;Science;Signal Transduction;Site;skills;stem cell biology;stem cells;T cell infiltration;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Thick;Three-Dimensional Imaging;tissue regeneration;Tissues;Toxic effect;translational immunology;translational model;translational potential;transplant model;Transplantation;Transplantation Conditioning;two-photon;Validation

PROJECT_TITLE: T cell invasion of the stem cell compartment during immune-mediated GI damage

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Although allogeneic bone marrow transplantation saves lives of patients with leukemia/lymphoma and certain solid cancers, this therapy is limited when transplanted bone marrow cells attack recipient organs, including skin, in the disorder termed acute graft-versus-host disease. This proposal focuses on how we can manipulate and enhance the skin’s own built-in system designed to suppress such life-threatening immune responses by focusing on a newly-discovered cell termed a dermal mesenchymal stem cell. If successful, we will develop new therapeutic approaches to harness the dermal mesenchymal stem cell to inhibit graft-versus-host disease, and potentially may other inflammatory conditions that affect skin and other vital organs.

PI_NAMEs: FRANK, MARKUS H.;FRANK, NATASHA Y;MURPHY, GEORGE F (contact)

PROJECT_TERMS: Acute Graft Versus Host Disease;Address;Affect;Allogeneic Bone Marrow Transplantation;Allogenic;Apoptosis;Attenuated;Biological Assay;Bone Marrow;Bone Marrow Cell Transplantation;Cell Communication;Cells;Cessation of life;Collaborations;Complication;Cutaneous;Cytokeratin;Cytokine Network Pathway;cytokine release syndrome;cytotoxic;Data;Dendritic Cells;Dermal;design;digital;Disease;Disease Progression;Epidermal Ridges;Epithelial Cells;epithelial injury;epithelial stem cell;Epithelium;Family member;Funding;Goals;graft vs host disease;Graft-Versus-Tumor Induction;Hair follicle structure;Home;Immune;immune reconstitution;Immune response;Immunophenotyping;immunoregulation;Immunosuppression;in vivo;Induction of Apoptosis;Inflammatory;knockout gene;Laboratories;laser capture microdissection;leukemia treatment;leukemia/lymphoma;Life;Limb structure;Liver;Malignant Neoplasms;Mediating;Mediator;Mesenchymal Stem Cell Transplantation;Mesenchymal Stem Cells;Messenger RNA;Minor Histocompatibility Antigens;Modeling;Monitor;Morbidity - disease rate;mouse model;Mucous Membrane;Multi-Drug Resistance;Mus;novel therapeutic intervention;Organ;Organ Culture Techniques;Organ Transplantation;Pathology;Pathway interactions;Patients;PD-1 pathway;PD-1/PD-L1;Phenotype;Prevention;programmed cell death ligand 1;programmed cell death protein 1;Proteins;Recovery;Research;Resistance;Resolution;RNA;Severity of illness;Site;Skin;skin disorder;Solid;Solid Neoplasm;spatiotemporal;stem cell biomarkers;stem cell engraftment;stem cell fate;stem cell function;Stem cell transplant;stem cells;stemness;synergism;System;T cell response;T-Lymphocyte;Therapeutic;tissue injury;Tissues;TP53 gene;Validation;Work;Xenograft Model

PROJECT_TITLE: Skin-Intrinsic Immunosuppressive Mesenchymal Stem Cells and aGVHD


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Depression;Heart Disease;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Nutrition;Obesity;Pediatric;Prevention;Serious Mental Illness;Women's Health Research

ORG_CITY: DENVER

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF DENVER (COLORADO SEMINARY)

ORG_STATE: CO

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) is the leading cause of death worldwide, risk begins early in life, and as a result, policy organizations are recommending that optimal promotion of cardiovascular health begin during childhood. Prenatal maternal depressive symptoms predict offspring cardiovascular risk, though this association has not been demonstrated experimentally; as such, the proposed research will follow up a sample of offspring from pregnant mothers who participated in a randomized controlled trial to test whether reducing prenatal maternal depressive symptoms improves offspring cardiovascular health in early childhood. This research will determine whether an established, effective psychosocial intervention to reduce depression during pregnancy also reduces cardiovascular risk early in life in the next generation.

PI_NAMEs: DAVIS, ELYSIA POGGI (contact);DOOM, JENALEE RAE;HANKIN, BENJAMIN L

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Address;Adult;adverse birth outcomes;Age;American Heart Association;antepartum depression;Arterial Fatty Streak;arterial stiffness;associated symptom;Barker Hypothesis;Behavior;Birth;Blood Pressure;Body fat;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cause of Death;Child;Child Behavior;Child Mental Health;Childhood;Clinical Trials;Cognitive;Data;Deposition;depressive symptoms;Development;Diabetes Mellitus;Diet;dietary;early childhood;Eating;Eating Behavior;effective intervention;efficacious intervention;emotion regulation;Emotional;emotional functioning;endothelial dysfunction;Epidemiology;Epigenetic Process;ethnic diversity;Exposure to;Fatty acid glycerol esters;Feeding behaviors;Feeds;follow-up;Food;food quality;Gestational Age;Goals;Health;Health behavior;Health Promotion;Hypertension;Immune;Impairment;improved;Informal Social Control;insulin sensitivity;Intervention;intrauterine environment;Knowledge;Life;life span;longitudinal design;Longitudinal Studies;Low Birth Weight Infant;Low income;Maternal Behavior;maternal depression;Mediating;Mediator;Metabolic;Modeling;Mothers;Neurosecretory Systems;next generation;Nursery Schools;Obesity;obesity in children;obesogenic;offspring;Organizational Policy;Outcome;Participant;Pathway interactions;Physical activity;Physiological;Physiology;postnatal;preference;Pregnant Women;Premature Birth;prenatal;prenatal intervention;Prevalence;Prevention;protective factors;psychosocial;racial diversity;Randomized, Controlled Trials;rapid infant weight gain;Recommendation;reduce symptoms;Research;Risk;Risk Factors;Sampling;sedentary lifestyle;Signal Transduction;Sleep;Stress;symptomatic improvement;System;Testing;Time;trial design;waist circumference;Work

PROJECT_TITLE: Reducing maternal prenatal depression to improve child cardiovascular health

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The limitations in our understanding of nonhomologous end joining (NHEJ) protein functions directly affect our approaches to the treatment of human diseases and cancers. This proposal is highly significant because it examines complex levels of NHEJ functions that have relevance to aberrant DNA replication and repair in cancer and other human syndromes.

PI_NAMEs: ROTHENBERG, ELI  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Affect;Architecture;Biochemical;Biological Assay;cancer therapy;Cell Cycle;Cells;Cellular biology;Chemotherapy and/or radiation;Chromosomal Breaks;Complex;Dependence;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Repair Pathway;Double Strand Break Repair;Filament;Genomic Instability;Goals;homologous recombination;Human;Human Development;human disease;human DNA;Hypersensitivity;improved;in vivo;innovation;Knowledge;Link;live cell imaging;Malignant Neoplasms;Mammalian Cell;Maps;Methods;Microscopy;Molecular;molecular imaging;Mutation;nanoscale;Nature;Nonhomologous DNA End Joining;Pathway interactions;Patients;Predisposition;protein function;Proteins;Regulation;Repair Complex;repaired;Research;Resistance development;response;Role;Severe Combined Immunodeficiency;single molecule;Site;structural biology;Syndrome;Techniques;Therapeutic;therapy resistant

PROJECT_TITLE: Mechanisms of Human DNA Double-Strand Break Repair via Quantitative Single-Molecule Imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Asthma;Cardiovascular;Heart Disease;Lung;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Cardiovascular disease is a leading cause of death in the United States and globally. To effectively treat and prevent cardiovascular disorders we need a better understanding of the molecular mechanisms which drive initiation and progression of disease. This work will reveal new details of the cellular networks involved in cardiovascular health and in the initiation and persistence of atrial fibrillation, which can cause stroke, heart failure and death.

PI_NAMEs: SWEENY, ELIZABETH A. (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Actins;Affect;Asthma;Atrial Fibrillation;Biochemical;biological adaptation to stress;Biological Assay;Blood Vessels;Calcium;Calcium Signaling;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Cause of Death;Cell model;Cell Physiology;Cells;Cessation of life;Cytoskeleton;Data;Diabetes Mellitus;Disease;Disease Progression;drug discovery;Enzymes;Family;Gene Expression;Heart;Heart failure;Heme;Hemeproteins;Homeostasis;human disease;Immunity;induced pluripotent stem cell derived cardiomyocytes;knock-down;Link;Malignant Neoplasms;member;Membrane;Metabolism;Mitochondria;Molecular;NADPH Oxidase;novel;overexpression;Oxidation-Reduction;Pathologic;Patients;Phase;Physiological;prevent;protein expression;protein protein interaction;reconstitution;Regulation;release of sequestered calcium ion into cytoplasm;response;RNA;Role;Signal Transduction;Sinus;Stimulus;Stroke;structural biology;Superoxides;System;Testing;Tissues;United States;Work

PROJECT_TITLE: Heme allocation and disruptions in asthma and the failing heart

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Wound Healing and Care

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Project Narrative This project addresses the crucial need for regulated delivery of cold medical plasma, based on real-time measurements, to reliably and reproducibly deliver plasma components that promote wound healing. We will develop a control system into which commercial sensors will be incorporated to detect when the effective dose of plasma has been applied to a wound. The system will be integrated into two different medical plasma devices and tested for automated control of plasma dose in a murine skin wound healing model.

PI_NAMEs: BERTHIAUME, FRANCOIS ;KREBS, FRED C.;MILLER, VANDANA ;STAPELMANN, KATHARINA  (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: Acceleration;Address;Atmosphere;Atmospheric Pressure;Biological;Biological Assay;Biological Markers;Biology;Biosensor;Calcium;Cell Death;Cells;Chemicals;Chemistry;Chronic;Clinical;clinical application;clinical effect;Clinical Trials;Complex;Dermatologic;Detection;Development;Devices;diabetic ulcer;disease model;Dose;Electromagnetic Fields;Elements;Engineering;Ensure;epithelial wound;Epithelium;experience;extracellular;Feedback;Feeds;Foundations;Gases;Goals;Grant;healing;Hour;Hydrogen Peroxide;In Situ;In Vitro;in vitro Model;in vivo;in vivo Model;Inbred BALB C Mice;Individual;innovation;Investigation;ionization;keratinocyte;Late Effects;Link;Machine Learning;Malignant Neoplasms;Measurable;Measurement;Measures;Medical;Medicine;Metabolism;Methods;Microscope;Modeling;Monitor;mouse model;Mus;Necrosis;Nitric Oxide;Nitrogen;North Carolina;Outcome;Outcome Assessment;Outcome Measure;Output;Oxidation-Reduction;Oxygen;pathogenic bacteria;pathogenic virus;Performance;Plasma;Plasma Enhancement;Play;Process;Property;Reactive Oxygen Species;Regulation;Reproducibility;Research;response;Role;sensor;side effect;Signal Transduction Pathway;Skin wound healing;Solid;System;Temperature;temporal measurement;Testing;Therapeutic;Therapeutic Uses;Time;Tissues;translational applications;Universities;Virus Diseases;wound;wound closure;wound healing;Wound models

PROJECT_TITLE: Development of a closed-loop control system for plasma medicine

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Neurosciences;Opioids;Pain Research;Palliative Care;Rare Diseases

ORG_DEPT: DENTISTRY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative The proposed research is relevant to public health because it focuses on developing a novel and alternative strategy using non-viral dual gene (DNA and RNA) delivery methodology to treat oral cancer pain. Once such strategies have been developed, there is the potential for a significant advance in anti-pain therapy for oral cancer patients suffering severe debilitating pain. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to reducing illness and disability.

PI_NAMEs: SCHMIDT, BRIAN L (contact);YAMANO, SEIICHI

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Absence of pain sensation;Afferent Neurons;Agonist;Animal Model;antagonist;Attenuated;attenuation;beta-Endorphin;Biological Assay;cancer cell;Cancer cell line;Cancer Etiology;cancer pain;Cancer Patient;cancer therapy;carcinogenesis;Cells;chemical carcinogen;Chronic;chronic neuropathic pain;Clinical Trials;clinically relevant;CRISPR/Cas technology;cytotoxicity;Data;debilitating pain;demethylation;Development;disability;DNA;DNA delivery;Down-Regulation;drinking;Drug usage;Eating;evidence base;functional restoration;Future;gene therapy;Generations;Genes;Genomics;Goals;Head and Neck Cancer;Heterogeneity;Human;in vivo;innovation;invention;knock-down;Knowledge;Legal patent;Life;Lipids;malignant mouth neoplasm;Malignant Neoplasms;Mechanics;Methodology;Methylation;Mission;mouse model;mu opioid receptors;Mus;Nerve;Nociception;non-opioid analgesic;non-viral gene therapy;Non-Viral Vector;Normal tissue morphology;novel;Opioid;Opioid Receptor;Oral;orofacial;Orofacial Pain;Outcome;Pain;Pain management;Pain Measurement;pain signal;PAR-2 Receptor;Pathway interactions;Patient Self-Report;Patients;Peptides;Peripheral;Permeability;Pharmaceutical Preparations;Phase I Clinical Trials;Pre-Clinical Model;Public Health;Quality of life;Receptor Gene;Regulation;Research;RNA;RNA Interference;side effect;Signal Pathway;Signal Transduction;Simplexvirus;Specificity;Testing;Therapeutic;Transfection;Translating;Treatment Efficacy;tumor microenvironment;United States National Institutes of Health;Variant;Viral Genes;Work;Xenograft procedure

PROJECT_TITLE: Intratumor co-delivery of DNA and RNA to relieve cancer pain

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative  At present there exists a schism between the rate of disease gene discovery and our present understanding of how mutations in such genes result in mental illness. Understanding of how mutations in these genes affect brain function at a cellular level has lagged behind. My proposal by coupling our expertise in studying the development of cortical interneurons, with the computational skills of the Bonneau laboratory, promises to bridge this gap.

PI_NAMEs: FISHELL, GORDON J (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adult;Affect;Appearance;Biological Process;Brain;Brain Diseases;Candidate Disease Gene;Cell Shape;Cells;Chromatin;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Computational Biology;Coupled;Coupling;Cues;Data;Development;Disease;Embryo;Embryonic Structures;Event;Excision;Four-dimensional;gene discovery;Gene Expression;Gene Expression Regulation;gene regulatory network;Generations;Genes;Genetic;Goals;Grant;hippocampal pyramidal neuron;in silico;Interneurons;Laboratories;Link;Maps;Medial;Mental disorders;Methods;Molecular;mutant;Mutation;Nature;Neurons;overexpression;Parvalbumins;Phase;Population;Positioning Attribute;postmitotic;Process;progenitor;programs;Pyramidal Cells;Role;Shapes;Signal Transduction;skills;Somatostatin;Specific qualifier value;Specificity;Synapses;Testing;Tetanus Toxin;Time;transcription factor;transcriptome;transcriptome sequencing;vesicular release;Work

PROJECT_TITLE: The molecular and cellular basis of cortical interneuron divergence

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: Princeton

ORG_DEPT: CHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative In this proposal, we describe the development of new synthetic methods and photocatalytic processes that are enabled by excited-state redox chemistry. This work aims to provide solutions to significant and long-standing gap in the synthetic literature and provides a basis for the development of novel methods to enable the construction of both complex targets and common pharmacophores. The reactions and processes enabled by these technologies will provide new tools to simplify the discovery, design and manufacture of drugs and other small molecule probes of biological function, creating a significant benefit for human health and the associated biomedical sciences. ! !

PI_NAMEs: KNOWLES, ROBERT R (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: New Synthetic Methods Enabled by Excited-State Redox Chemistry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Immune therapy has become a standard treatment for multiple types of cancers and ultimately relies on T cells to kill tumor cells; however, we don’t yet fully understand the relationship between how T cells kill tumors and how cell death pathways in tumors lead to their death. CAR T cells are engineered T cells that kill lymphoid tumors by targeting a specific protein on their surface, and are now standard treatment for lymphoid cancers. We propose to examine the mechanisms by which CAR T cells kill tumors, and define the programmed cell death pathways in tumor cells that enable susceptibility and resistance to CAR T cell killing, with the goal of using specific combinations of drugs and engineering approaches to enhance T cell-mediated tumor killing.

PI_NAMEs: MAUS, MARCELA VALDERRAMA (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Affect;Alleles;Antibodies;Antigen Targeting;Antigens;Apoptosis;Apoptotic;Attention;BCL1 Oncogene;Biological Assay;cancer cell;cancer type;CAR T cell therapy;CD19 Antigens;CD19 gene;CD8B1 gene;Cell Death;Cell Death Induction;Cell Death Signaling Process;cell killing;Cell-Mediated Cytolysis;Cells;Cessation of life;chimeric antigen receptor T cells;cytotoxicity;Data;density;drug candidate;Drug Combinations;Drug resistance;effector T cell;engineered T cells;Engineering;Epidermal Growth Factor Receptor;functional genomics;gain of function;gene-editing approach;Genetic;genetic approach;Genetic Engineering;Genomic approach;Glioblastoma;Goals;Granzyme;Hematopoietic Neoplasms;Immune system;Immunology;Immunotherapy;In Vitro;in vivo;inhibitor;innovation;invention;knockout gene;Laboratories;Lead;Life;Liquid substance;loss of function;lymphoid neoplasm;Lymphoma;Malignant lymphoid neoplasm;Malignant Neoplasms;Mediating;Mitochondria;mouse model;Multiple Myeloma;Mus;mutant;Mutation;neoplastic cell;Pathway interactions;Patients;perforin;Pharmaceutical Preparations;Pharmacogenetics;pharmacologic;Plasma Cells;Predisposition;Proteins;Receptor Signaling;Resistance;resistance mechanism;response;Signal Transduction;small molecule;Solid;Solid Neoplasm;standard care;Surface;T-Lymphocyte;Testing;tool;tumor;Tumor Biology;Tumor Cell Line;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Understanding and manipulating programmed cell death (PCD) pathways to facilitate lymphoid tumor killing by CAR T cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Genetics;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: We aim to make a unique impact on the tissue repair field by examining conserved yet under-studied organ regeneration processes. Our proposed studies impact fundamental biology related to the extent of organ regeneration needed to prevent permanent organ deformities, the specification of an organ repair program that is essential for repair of mammalian organs such as the kidney and cornea, and the prevention of invasive stem cell-based cancers.

PI_NAMEs: FOX, DONALD T. (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Address;analog;Area;Biology;Bladder;Cardiovascular Diseases;Cell Cycle;Cell Cycle Regulation;Cell division;cell injury;Cell Size;Cell Survival;Cells;Cornea;Cues;cytokine;Data;Deformity;DNA Damage;Drosophila genus;Epithelial Cells;Epithelium;Esophagus;Evolution;Family;Funding;Gene Expression;Genetic;genetic approach;Genetic Transcription;Genome;Grant;Hindgut;hormonal signals;hormone regulation;Hybrid Cells;Hybrids;Hyperplasia;injured;Injury;injury and repair;innovation;Kidney;Knowledge;Laboratories;Large Intestine;Lead;lead candidate;Malignant Neoplasms;Mediating;member;Midgut;Mitosis;Mitotic;Modeling;Molecular;Multiple Trauma;Natural regeneration;novel;Organ;Organ Model;organ regeneration;organ repair;Pathway interactions;Play;Ploidies;Polyploid Cells;Polyploidy;Population;Positioning Attribute;prevent;Prevention;Process;programs;Property;Pylorus;Recurrence;Regulation;repaired;Reporting;Repression;response;response to injury;Role;S phase;severe injury;Severities;Signal Transduction;Small Intestines;Specific qualifier value;stem cells;steroid hormone;Steroids;Stomach;System;tissue injury;tissue regeneration;tissue repair;tissue-repair responses;Tissues;transcription factor;transcriptome sequencing;transcriptomics;tumor;Tumor Cell Invasion;Tumor Stem Cells;tumorigenesis;whole genome;Work

PROJECT_TITLE: Polyploidy after tissue injury: a Drosophila model

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative Nicotinamide phosphoribosyl transferase (NAMPT) is a rate-limiting enzyme in the NAD+ salvage pathway and plays an essential role in neuronal degeneration and energy metabolism, but genetic diseases caused by NAMPT variants have not been clinically reported and recognized. Current application will conduct in-depth study on the pathogenesis and mechanism of motor neuron (MN) and muscle degeneration of a novel disease caused by a P158A mutation in NAMPT protein using both in vitro patient-derived MN and in vivo mouse models.

PI_NAMEs: DING, SHINGHUA  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: 13 year old;Aging;Anabolism;Animals;Atrophic;Axon;axonal degeneration;base;Binding;Biochemical Reaction;Bioenergetics;Biological Assay;Biological Process;Brain;Cell Death;Cell division;Cells;Cessation of life;Citric Acid Cycle;Clinical;Code;cofactor;Data;Dendritic Spines;Development;Diagnosis;Disease;Disease Progression;DNA Repair;Electron Transport;Electrophysiology (science);Energy Metabolism;Enzymes;Essential Genes;Fibroblasts;fluorescence imaging;Foot Deformities;Functional disorder;Gene Expression Profiling;gene function;Genes;Genetic Diseases;Glycolysis;Goals;Hand deformities;Hereditary Motor and Sensory Neuropathies;Human;human disease;human induced pluripotent stem cells;Image;In Vitro;in vivo;Inborn Errors of Metabolism;induced pluripotent stem cell;Inherited;Ischemic Stroke;Link;Lower Extremity;Mammalian Cell;Mammals;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;mitochondrial dysfunction;Molecular;Motor;Motor Cortex;motor impairment;motor neuron degeneration;Motor Neurons;mouse model;Mus;Muscle;muscle degeneration;Muscle Fibers;Muscle Weakness;mutant;mutant mouse model;Mutant Strains Mice;Mutation;Nerve Degeneration;Nervous System Disorder;Neuroglia;neuromuscular function;Neuromuscular Junction;neuron loss;Neuronal Dysfunction;Neurons;Neuropathy;Niacinamide;Nicotinamide adenine dinucleotide;Nicotinamide Mononucleotide;nicotinamide phosphoribosyltransferase;novel;Oxidative Phosphorylation;Oxidative Stress;Paralysed;patch clamp;Pathogenesis;Pathologic;Pathway interactions;Patients;Pentose Phosphate Cycle Pathway;Phenotype;Play;Preparation;Production;protective effect;Proteins;Recombinants;Reporting;Respiration;response;Role;Sensory;Siblings;Signal Transduction;Single Nucleotide Polymorphism;Skin;Stable Isotope Labeling;Stress;Structure;Symptoms;Synapses;synaptic function;Technology;Testing;Time;Tissues;tool;Transferase;two-photon;Variant;Western Blotting;Wheelchairs;Wild Type Mouse

PROJECT_TITLE: Pathogenesis and motor neuron degeneration of a novel disease associated with a P158A mutation in NAMPT

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: FD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: GALVESTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Project Narrative This project allows the continuation and expansion of an existing unique educational program specifically designed to enable the conduct of nonclinical studies and clinical research trials in maximum containment laboratories and barrier nursing environments in a manner that assures the quality and integrity of the data. The program provides a learning environment that promotes collaboration of ideas, provides tools for study conduct, enhances mutual understanding of scientific and regulatory complexities, and promotes the quality and integrity of data derived from these studies. The result is a better prepared cohesive community of scientific and regulatory experts mutually engaged in, and committed to, the development and approval of medical countermeasures for high consequence pathogens.

PI_NAMEs: BRASEL, TREVOR ;EITZEN, MELISSA  (contact)

PROGRAM_OFFICER_NAME: ORR, ROBERT

PROJECT_TITLE: An Educational Program to Enhance Data Quality and Integrity for Regulated Studies Supporting the Advancement of Medical Countermeasures for High Consequence Pathogens


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: Project Narrative  How the dorsal striatum contributes to reward-seeking and punishment-avoidance behaviors in healthy and disease conditions remains unclear. In the proposed research program, we will test the hypotheses that distinct striosome populations in the dorsal striatum differentially control reward seeking and punishment avoidance through different circuit mechanisms, and these neurons become dysfunctional after stress, thereby causing maladaptive behaviors. Findings from this project will have important clinical implications, as striatal dysfunctions have been implicated in depression and drug addiction.

PI_NAMEs: TOLLKUHN, JESSICA  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Address;Affect;Anatomy;Anxiety Disorders;autism spectrum disorder;avoidance behavior;Basal Ganglia;Behavior;Behavioral;Brain;Calcium;Clinical;Code;Corpus striatum structure;Cyclic AMP-Dependent Protein Kinases;Disease;dopaminergic neuron;Dorsal;Drug Addiction;Electrophysiology (science);Evaluation;Family;fluorescence lifetime imaging;Foundations;Functional disorder;Ganglia;Genetic;Globus Pallidus;Goals;Habenula;Health;Huntington Disease;in vivo;in vivo imaging;Knock-in Mouse;Label;Learned Helplessness;Learning;Life Stress;maladaptive behavior;Maps;Mediating;Mental Depression;Mental disorders;Midbrain structure;Monitor;Mood Disorders;Moods;motivated behavior;Motivation;Motor;motor control;mouse genetics;Movement;multiplexed imaging;Mus;Negative Reinforcements;Negative Valence;Nervous System Disorder;neurochemistry;Neurons;novel;Obsessive-Compulsive Disorder;Opioid Receptor;optogenetics;Parkinson Disease;Pathway interactions;Play;Population;Population Control;Positive Reinforcements;Positive Valence;Predisposition;Procedures;prodynorphin;programs;Property;Psychological reinforcement;Publishing;Punishment;Regulation;Research;resilience;Rewards;Role;Shapes;Signal Transduction;social defeat;Stimulus;Stress;Stressful Event;striosome;synaptic function;Techniques;Testing;tool;two-photon;Zinc Fingers

PROJECT_TITLE: Dissecting basal ganglia circuits underlying motivated behaviors


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

PHR: Project Narrative Although the implementation of whole genome sequencing in a clinical setting has greatly facilitated the detection of birth defect-associated genetic variants, distinguishing the specific variants that cause congenital birth defects remains a major challenge. This project aims to address current obstacles in variant interpretation through the application of innovative experimental approaches and scalable genomic technologies to profile the functional and phenotypic consequences of congenital defect-associated genetic variants identified in undiagnosed rare disease patients. These methods will rapidly accelerate the process of identifying causal variants and in some cases may reveal previously unappreciated avenues for therapeutic intervention.

PI_NAMEs: YOUNGER, SCOTT T (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Acceleration;Address;Animal Model;Animals;Biological Assay;Catalogs;causal variant;Cells;Childhood;Clinical;clinical phenotype;clinical sequencing;Clustered Regularly Interspaced Short Palindromic Repeats;Congenital Abnormality;Coupled;CRISPR screen;data repository;Defect;Detection;Development;Diagnosis;Disease;disease phenotype;Embryo;Engineering;exome sequencing;Gene Expression;Gene Modified;Genes;Genetic;genetic variant;Genome;genome editing;Genome engineering;genome sequencing;genome-wide;Genomics;Goals;improved;induced pluripotent stem cell;innovation;Lead;loss of function;loss of function mutation;Methods;Modeling;novel;Organoids;patient derived induced pluripotent stem cells;patient population;Patient Selection;patient subsets;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Process;programs;Property;Proxy;Quality of life;Rare Diseases;rare variant;Regulatory Element;Reporter;Reporter Genes;repository;Resources;RNA Splicing;Role;Sampling;screening;Series;Spliced Genes;System;Technology;Therapeutic Intervention;transcriptomics;Translating;Untranslated RNA;Validation;Variant;variant detection;whole genome;Work;Zebrafish

PROJECT_TITLE: Systematic Identification and Phenotypic Characterization of causal genetic variants in Rare Disease-Associated Birth Defects

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: NORTH CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

ORG_STATE: IL

PHR: Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS) and primary effusion B-cell lymphoma (PEL). The studies proposed here will evaluate the therapeutic potential of nucleolin targeting G-quadruplex forming anti-nucleolin aptamer AS1411 in KSHV replication and pathogenesis.

PI_NAMEs: SHARMA-WALIA, NEELAM  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: angiogenesis;Angiogenesis Inhibitors;Angiogenic Factor;anti-cancer;Anti-viral Agents;Antibodies;antiretroviral therapy;aptamer;autocrine;B-Cell Lymphomas;B-Cell NonHodgkins Lymphoma;Biogenesis;Biology;Blood Vessels;body cavity;cancer therapy;Cell Death Induction;Cell Line;Cell Survival;Cells;Cellular Metabolic Process;Chemicals;chemotherapy;chromatin remodeling;co-infection;Cyclophosphamide;cytokine;Development;Diagnosis;DNA;Dose;Doxorubicin;effusion;Endothelial Cells;Endothelium;Environment;Etiology;Exhibits;Family;G-Quartets;gammaherpesvirus;Gene Expression;Gene Proteins;Genes;Growth Factor;hematopoietic tissue;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;histone modification;HIV;HIV therapy;Human;Human Herpesvirus 8;Human poliovirus;Immunocompromised Host;in vitro Model;in vivo Model;Incubated;Infection;Inflammatory;Integration Host Factors;Interleukin-6;Intervention;Kaposi Sarcoma;Knowledge;latency-associated nuclear antigen;latency-associated protein;Lesion;Life Cycle Stages;Link;Lymphangiogenesis;Lymphoid Tissue;Lymphoma cell;Lytic;Lytic Phase;Maintenance;Malignant Neoplasms;Mediating;member;Messenger RNA;Metabolic Pathway;Morbidity - disease rate;mortality;Multicentric Angiofollicular Lymphoid Hyperplasia;novel;nucleolin;Oligonucleotides;Paracrine Communication;Pathogenesis;Pathway interactions;Patients;Pharmacy (field);Phase;Post-Transcriptional Regulation;Prednisone;primary effusion lymphoma;Prognosis;programs;Proliferating;Proteins;rare cancer;Respiratory syncytial virus;Ribosomes;RNA-Binding Proteins;Role;Safety;Serious Adverse Event;Shapes;Signal Transduction;Skin Kaposi's Sarcoma;skin lesion;Skin Tissue;Syndrome;Telomerase;Testing;theranostics;Therapeutic;Transcription Coactivator;Transcriptional Regulation;Translational Regulation;tumor;tumorigenic;uptake;Vascular Endothelial Cell;Vincristine;Viral;Viral Cancer;Viral Genes;Viral Regulatory Proteins;Virion

PROJECT_TITLE: Anti-nucleolin aptamer AS1411: Applications in Kaposi's Sarcoma Associated Herpes Virus (KSHV) biology

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Narrative: Synaptic damage is associated with many neurodegenerative diseases and traumatic injuries; however, the underlying pathologies that lead to synaptic damage and losses are poorly defined. Our studies examine how prolonged release of D-serine by microglia leads to synaptic damage through hyper-activation of NMDA receptors that target dendritic spines for degradation and pruning in both murine and human tissues.

PI_NAMEs: LIEBL, DANIEL JON (contact);WOLOSKER, HERMAN

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acceleration;Acute;Address;Aging;Agonist;Alzheimer's Disease;Amino Acid Transporter;Amino Acids;Astrocytes;Attention;Autopsy;Behavior;behavior measurement;Brain;brain cell;brain circuitry;Brain Injuries;Cells;Cellular Structures;central nervous system injury;Cognition;Cognitive;cognitive function;Complement;Complex;Conscious;Dementia;Dendritic Spines;Electrophysiology (science);Event;experimental study;extracellular;Functional disorder;Gene Targeting;Genetic;Genetic Techniques;Glycine;high resolution imaging;Human;human model;human tissue;Huntington Disease;Imaging Techniques;Impaired cognition;in vivo;injured;Injury;interdisciplinary approach;Intervention;laser capture microdissection;Link;Mediating;Mediator;Microdialysis;Microglia;Modeling;mouse model;Mus;N-Methyl-D-Aspartate Receptors;neural;Neurodegenerative Disorders;Neuroglia;Neurons;neurotransmission;novel;novel therapeutics;Nuclear RNA;Parkinson Disease;Pathologic;Pathology;Patients;pharmacologic;Phase;Play;preservation;Process;Research Personnel;response;Rodent;Role;Serine;Source;Synapses;Synaptic plasticity;Synaptic Transmission;Tissues;transcriptome sequencing;transcriptomics;Translating;translational potential;Traumatic Brain Injury;Traumatic injury;United States National Institutes of Health

PROJECT_TITLE: Stabilizing the Tripartite Synaptic Complex Following TBI

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative The receptive fields neurons in primary somatosensory cortex of primates have excitatory centers, suppressive near surrounds on same hand, and far surrounds on the other hand. We will determine the neural sources of these features, and reveal how sensory loss alters these features, even after long-term recovery from spinal cord injury.

PI_NAMEs: KAAS, JON H (contact);QI, HUI-XIN

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Affect;Area;Behavior;Cell Nucleus;Characteristics;Complex;Contralateral;Data;Disinhibition;dorsal column;Electrodes;Evolution;excitatory neuron;Feedback;Hand;hand dysfunction;Hand functions;Impairment;inhibitory neuron;Ipsilateral;Lesion;Location;long term recovery;Manuals;Maps;Mediating;Methods;Monkeys;neural;Neurons;Pathway interactions;Primates;Process;Qi;receptive field;Recovery;Research;Rest;Sensory;sensory input;Site;Skin;somatosensory;Somatosensory Cortex;Source;Spinal Cord;Spinal cord injury;Spinal Cord Lesions;Stimulus;Structure of nucleus cuneatus;System;Tactile;tactile stimulation;Thalamic structure;Therapeutic Intervention;Touch sensation

PROJECT_TITLE: Area 3b hand cortex in primate: the targets and sources of extra-hand suppressive surrounds

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ORTHOPEDICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Surgical repair of tendon to bone is a long-standing clinical challenge. The high failure rates after rotator cuff repair are due to a lack of regeneration of the native functionally graded enthesis connecting tendon and bone. The aim of this project is to develop and validate a novel class of stem cell-seeded biomimetic scaffolds to regenerate the enthesis after rotator cuff repair.

PI_NAMEs: THOMOPOULOS, STAVROS  (contact);XIA, YOUNAN

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Address;Adult;Agonist;Animal Model;anterior cruciate ligament reconstruction;Architecture;Biomedical Engineering;Biomimetics;bone;Bone Development;bone healing;bone repair;cell motility;Cells;Chondrocytes;Clinical;clinically relevant;comparison control;Connective Tissue;Control Groups;cost;Cues;Deposition;design;Development;efficacy testing;Elderly;Equilibrium;Erinaceidae;Extracellular Matrix;fabrication;Failure;Geometry;Goals;healing;Human;improved;improved outcome;In Vitro;injured;Injury;injury and repair;Interdisciplinary Study;Lasers;Ligaments;Location;materials science;Mechanics;Meniscus structure of joint;Mesenchymal Stem Cells;Methods;mineralization;Minerals;Modeling;Modulus;Muscle;musculoskeletal injury;Nanotechnology;Natural regeneration;neonatal mice;neonatal period;novel;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Oryctolagus cuniculus;Osteoblasts;Outcome;Pathology;patient population;Phenotype;Physiological;Population;Postoperative Period;prevent;Recreation;repaired;Research Project Grants;response;Rotator Cuff;rotator cuff injury;rotator cuff tear;scaffold;Shapes;Shoulder;Site;stem cell population;stem cells;Stress;Structure;Study models;Tendon structure;Testing;Tissue Engineering;Tissues;Translating;translational study;Translations;United States;Universities

PROJECT_TITLE: Biomimetic approaches for enthesis tissue engineering

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Osteoarthritis;Pain Research;Physical Activity;Prevention

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MARQUETTE UNIVERSITY

PHR: PROJECT NARRATIVE CAPPA is a physical activity intervention for employees with chronic knee pain, which is being tested in a developmental randomized controlled trial at two partnering worksites in the Midwest. CAPPA is assessing whether an action planning intervention supporting physical activity can increase and sustain physical activity in employees with chronic knee pain. Knee osteoarthritis is a major public health problem and a leading cause of disability and productivity loss among persons in the workforce. The goal of this program is to develop and assess a low resource physical activity coaching intervention to large groups of employees at risk for knee osteoarthritis. The CAPPA intervention is administered by health coaches, who will use data transmitted from a Fitbit tracker via our customized remote coach interface and Movement Dashboard to 1) support employees in making physical activity action plans for their health, 2) use data transmitted from a personal fitness tracker (Fitbit) to support coach and employee knowledge about physical activity performance, 3) use data about physical activity to suggest optimal timing to step up to higher resource treatments in future research studies. This project has the potential to have a lasting impact on improving symptoms and quality of life of persons with chronic knee pain and decreasing the functional limitations, productivity losses, and soaring healthcare costs associated with knee OA.

PI_NAMEs: CHANG, ROWLAND W;PINTO, DANIEL  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Accelerometer;actigraphy;Address;Adult;Advocate;Age;Aging;Arthritis;attentional control;Behavior;Behavior Therapy;Behavioral;Blue Cross;Blue Shield;Caring;Chronic;Clinical;clinical care;Clinical Trials;Communication;Communities;Computers;cost;COVID-19;dashboard;Data;data exchange;design;Development;Devices;disability;Disease;Dose;Education;effective intervention;Effectiveness;Employee;Employee Health;evidence base;exercise intervention;exercise program;experience;Feedback;fitbit;fitness;follow-up;functional improvement;Future;Goals;Guidelines;Health;health administration;Health Care Costs;Health Resources;Health Technology;Healthcare;Illinois;improved;Incentives;Individual;Infrastructure;Intervention;Interview;Knee;Knee Osteoarthritis;knee pain;knee replacement arthroplasty;Knowledge;Life Style;Link;Measures;meetings;member;Midwestern United States;modifiable risk;Monitor;mortality;Movement;novel;Obesity;Outcome;Pain;pain relief;Participant;Patient Self-Report;Pattern;peer;Performance;person centered;Persons;Physical activity;Physical Function;Pilot Projects;Population;Predictive Value;prevent;primary outcome;Productivity;productivity loss;programs;Protocols documentation;Public Health;Quality of life;Randomized, Controlled Trials;Recommendation;recruit;Replacement Arthroplasty;Research;research study;Resources;Rheumatology;Risk;Risk Factors;secondary outcome;sedentary;Services;Site;Societies;Structure;support tools;symptomatic improvement;Symptoms;Technology;Technology Assessment;telecoaching;Testing;Text;Time;tool;treatment arm;treatment effect;Treatment Efficacy;ubiquitous computing;Universities;video chat;Voice;Wellness Program;Work;Workplace

PROJECT_TITLE: Computer-guided Action Planning to Support Physical Activity (CAPPA) for Employees with Chronic Knee Symptoms

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC(10)]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Emerging Infectious Diseases;Immunization;Infectious Diseases;Rare Diseases;Vaccine Related

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Measles: A Global History Project Narrative This research project will produce a global history of measles, one of the oldest, most familiar, extensively studied, preventable, and still-epidemic infectious diseases of humans. The final outcome of this project will be a book manuscript that, by tracing measles' history from medieval times to the present, will show how scientific and sociopolitical conceptions and perceptions of the disease rooted in space and time have made measles both a stable and dynamic illness. The book's analysis will also reveal how measles management strategies, from quarantine to vaccination, have yielded an array of cultural, political, economic, and medical meanings of the disease over time, with implications for measles' symbolic and practical significance in scientific, popular, and political discussions about the management of other infectious diseases, from smallpox to COVID.

PI_NAMEs: CONIS, ELENA CHRISTINE (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TITLE: Measles: A Global History


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Social anhedonia—a reduced tendency to enjoy interpersonal relationships and/or reduced interest in social interactions—presents a significant public health challenge. This application aims to advance our understanding of the underlying mechanisms of social anhedonia by probing a process that is hypothesized to be central to social anhedonia: disrupted social reward learning. The findings of this project will provide valuable insights into the mechanical pathways of social anhedonia and could provide novel neurobehavioral phenotypes that can serve as targets and biomarkers for developing novel treatments.

PI_NAMEs: GREEN, MICHAEL F.;LEE, JUNGHEE  (contact);NUECHTERLEIN, KEITH H

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Affect;affective neuroscience;Anhedonia;Anterior;behavior change;Behavioral;Biological Markers;cingulate cortex;Clinical;Conceptions;design;Dorsal;early psychosis;Elements;experience;first episode psychosis;Functional Magnetic Resonance Imaging;Future;group intervention;Group Interviews;hedonic;indexing;Individual;insight;interest;Interpersonal Relations;Intervention;Knowledge;Learning;Measures;Mechanics;Mental disorders;Methods;motivational enhancement therapy;neural;neurobehavioral;neuroimaging;Neurosciences;novel;nutrition;Participant;Pathway interactions;Phenotype;pleasure;Population;Positive Reinforcements;Prefrontal Cortex;Process;Psychoses;psychotic;Psychotic Disorders;Public Health;Randomized;recruit;Reporting;response;Rewards;Role;Sampling;Seminal;severe mental illness;sex;Site;social;Social Functioning;social influence;Social Interaction;Specificity;Theoretical model;theories;Time;Ventral Striatum;Work

PROJECT_TITLE: Determining the role of social reward learning in social anhedonia in first-episode psychosis using motivational interviewing as a probe in a perturbation-based neuroimaging approach

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Cancer;Colorectal Cancer;Complementary and Integrative Health;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it develops hydrogel-based materials for localized drug delivery to treat gastrointestinal diseases. Intestinal disorders including inflammatory bowel disease (Crohn's disease, ulcerative colitis), irritable bowel syndrome, and colorectal cancer are significant public health concerns that affect millions of Americans each year, and drug delivery for localized delivery can improve clinical outcomes when compared to systemic administration of drugs. The proposed research will provide materials for 3D printed drug delivery devices that can deliver a broad range of therapeutics for an indefinite period of time.

PI_NAMEs: NELSON, ALSHAKIM  (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: 3-Dimensional;3D Print;Acrylates;Affect;Alkaloids;American;Anti-Inflammatory Agents;aqueous;Bacteria;Berberine;Biodegradation;Biological Availability;Biological Preservation;Biological Process;Biomedical Technology;Caco-2 Cells;Cells;Clinical;Colon Carcinoma;Colorectal Cancer;copolymer;Crohn's disease;Cytoprotection;cytotoxicity;design;Development;Devices;digital models;Disease;Drug Delivery Systems;drug production;effective therapy;Engineering;Epithelium;Escherichia coli;Excision;experimental study;fabrication;Formulation;Gastrointestinal Diseases;globular protein;Goals;Growth;gut microbiome;Human Microbiome;Hydrogels;Immobilization;improved;In Situ;In Vitro;in vitro Model;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Intestinal Diseases;Intestines;Irritable Bowel Syndrome;local drug delivery;Malignant Neoplasms;mechanical properties;Medical Device;metabolic engineering;Microbe;microorganism;Modeling;Modulus;monomer;Needles;next generation;Outcome;Patients;Performance;Pharmaceutical Preparations;Plant Resins;polymerization;Polymers;prevent;Production;programs;Proteins;prototype;Public Health;Publishing;Research;response;Stents;synthetic biology;System;Technology;Testing;Therapeutic;Therapeutic Agents;Time;Translations;treatment duration;Treatment Efficacy;tumor;Ulcerative Colitis;Validation;Variant;virtual;Water;Weight;Work;Yeasts

PROJECT_TITLE: 3D Printed Engineered Living Materials for Drug Delivery

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Biotechnology;Immunization;Immunotherapy;Infectious Diseases;Lymphatic Research;Vaccine Related

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The goal of this proposal is to determine the physiology and pathophysiology of lymphatic transport following cutaneous challenge and its contribution to cutaneous immune surveillance. Completion of this work may establish lymphatic-dependent design principles for tuning cutaneous immune responses from vaccine development to tolerance and tumor immunotherapy.

PI_NAMEs: LUND, AMANDA W. (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Antigen Presentation;Antigens;Autoimmunity;Automobile Driving;Biology;CD8-Positive T-Lymphocytes;cell motility;Cells;Chronic;Clinical;combat;Communication;Cutaneous;Data;Dendritic Cells;Dependence;Dermal;Dermatopathology;Dermis;design;draining lymph node;Equilibrium;Exhibits;fluid flow;Functional disorder;Genetic;Goals;Hematopoietic;high resolution imaging;Homeostasis;Immune;immune activation;immune checkpoint blockade;Immune response;Immunity;Immunologic Surveillance;Immunology procedure;immunoreaction;Immunotherapeutic agent;Impairment;in vivo;Inflammation;Inflammatory;insight;Intercellular Fluid;interstitial;KDR gene;Knockout Mice;Knowledge;Leukocytes;Ligands;Link;Liquid substance;Lymph;lymph nodes;Lymphatic;Lymphatic Capillaries;lymphatic circulation;Lymphatic Endothelial Cells;Lymphatic Endothelium;lymphatic vasculature;lymphatic vessel;Malignant Neoplasms;Mediating;migration;Molecular;Mus;neoplasm immunotherapy;novel;novel therapeutics;pathogen;Pathway interactions;Phenotype;Physiological;Physiology;pressure;Proliferating;Publishing;Resolution;response;Role;Route;Sentinel;Signal Transduction;Skin;Source;Structure of germinal center of lymph node;System;T cell response;Testing;Therapeutic;tool;transcriptomics;Translating;treatment response;vaccine development;vaccine immunogenicity;vaccine immunotherapy;vaccine response;VEGFA gene;Viral;Virion;Virus;Virus Diseases;Work

PROJECT_TITLE: Dermal Lymphatic Transport and Cutaneous Immune Balance

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The objectives of the grant are to train M.D. and Ph.D. post-doctoral fellows in the application of genomics to infectious diseases, and to prepare them for successful, productive, independent careers that have a significant impact on the health-related research needs of the nation. The training program will exploit the world-class resources and leadership at the host institution in the field of genomics. Graduating trainees from this program will be unusually well-prepared to enhance the public health through the application of this powerful field of science.

PI_NAMEs: JAGANNATHAN, PRASANNA  (contact);RELMAN, DAVID A.

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Communicable Diseases;Genomics

PROJECT_TITLE: Applied Genomics in Infectious Diseases

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Estrogen;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with poor survival. This research proposal is based on strong preliminary data showing that Estrogen Receptor beta (ERβ) exerts tumor suppressive functions in GBM. This proposal is will develop novel ERβ agonists that promote tumor suppression leading to a new therapeutic modality to treat GBM. Identification of CIDD-ERβ agonists as a therapeutic agent can be readily translated into clinical use with current chemo and radiation therapies, providing an additional tool for enhancing survival in GBM patients.

PI_NAMEs: BRENNER, ANDREW JACOB;MCHARDY, STANTON FURST;VADLAMUDI, RATNA K (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Adjuvant Chemotherapy;Adult;Agonist;Apoptosis;Binding;Biological Assay;Biological Availability;biophysical techniques;Brain;Cells;Central Nervous System;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical development;Clinical Research;clinical translation;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Combined Modality Therapy;CRISPR/Cas technology;cross reactivity;Data;design;Development;Diagnosis;DNA Damage;drug discovery;efficacy testing;ESR1 gene;Estrogen Receptor 2;Estrogen Receptors;Estrogens;Evaluation;Excision;External Beam Radiation Therapy;Failure;female sex hormone;Fluorescence Resonance Energy Transfer;Genomics;Glioblastoma;Glioma;Gliomagenesis;Growth;Histone Deacetylase Inhibitor;Human;Hydroxyl Radical;improved;In Vitro;in vitro Assay;in vivo;Industry;innovation;Knock-out;Lead;Ligands;Malignant neoplasm of brain;Malignant Neoplasms;Maximum Tolerated Dose;Mediating;meter;Modality;Modeling;Molecular;non-genomic;novel;novel therapeutics;Operative Surgical Procedures;Oximes;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Play;pre-clinical;Process;Property;Radiation therapy;Reporter;Research Proposals;Resistance;response;Risk;Role;Specificity;standard care;standard of care;stem cells;stemness;Structure;Structure-Activity Relationship;Survival Rate;temozolomide;Testing;Tetralones;Therapeutic;Therapeutic Agents;Time;tool;Toxic effect;Toxicology;Translating;tumor;tumor initiation;tumor progression;Tumor Promoters;Tumor Promotion;Tumor Suppression;Tumor Suppressor Proteins;Validation;xenoestrogen;Xenograft procedure

PROJECT_TITLE: Development of Potent Estrogen Receptor Beta Agonists for Treating Glioblastoma

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Cancer

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The Hippo pathway plays crucial roles in various physiological processes and is frequently altered in cancer development. The overall goal of this R01 proposal is to elucidate the regulation and function of the Hippo pathway in growth control and tissue homeostasis. Completion of this project will enrich our understanding of the Hippo pathway in normal physiology and lay the molecular foundation for developing new therapeutic strategies for cancer treatment.

PI_NAMEs: WANG, WENQI  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Adaptor Signaling Protein;Autophagocytosis;Autophagosome;Basic Science;Binding;Binding Proteins;biological adaptation to stress;Cancer Cell Growth;cancer therapy;Cell Nucleus;Cell Survival;Cells;comparative;Complex;Cytoplasm;Data;Development;Drosophila genus;Event;Family;Foundations;Genetic Transcription;Glucose;Goals;Grant;Growth;Growth Factor;Head and Neck Cancer;Head and Neck Neoplasms;Homeostasis;Human;human disease;insight;interest;Lipids;Lysosomes;Malignant Neoplasms;Mammals;mechanical signal;Mediating;Metabolic Pathway;Modeling;Molecular;Natural regeneration;novel;novel therapeutic intervention;Nuclear;Nuclear Translocation;Oncogenic;Organ Size;Pathway interactions;Phosphatidic Acid;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological Processes;Physiology;Play;Process;programs;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Proteomics;Recycling;Regulation;response;Role;Series;Signal Transduction;Site;Starvation;Stimulus;Stress;Testing;Tissues;transcription factor;Translational Research;tumor growth;tumor metabolism;tumor xenograft;upstream kinase

PROJECT_TITLE: Regulation and function of the Hippo pathway in growth control

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Adrenocortical carcinoma (ACC) is an aggressive malignancy with a poor 5-year survival rate of 6% for patients with metastatic disease and there are no targeted therapies for these patients. The failure to identify more effective treatments can partially be attributed to the lack of appropriate preclinical research models that accurately model ACC metastasis and support the key biological pathways implicated in ACC progression. To address these critical research gaps, we will use our newly developed patient-derived organoid (PTO) model of ACC from patient samples as well as an ACC PTO metastasis-on-a-chip (MOC) microfluidic platform with onboard biosensing of cell migration to determine the roles of IGF, Wnt, and cell cycle regulation-based signaling on ACC metastasis.

PI_NAMEs: DEDHIA, PRIYA HARAKH;LEIGHT, JENNIFER ;SKARDAL, ALEKSANDER  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: 3-Dimensional;Address;Adrenocortical Carcinoma;Animal Model;beta catenin;Biological;Biological Models;Biology;Biosensing Techniques;Biosensor;Cell Cycle;Cell Cycle Regulation;Cell Line;cell motility;Cell Proliferation;Cell Separation;Cell Survival;cell type;Cells;Circulation;Clinical;Complex;Confocal Microscopy;Data;Devices;Disease;Disease Progression;Distant;Drug resistance;drug sensitivity;effective therapy;Event;Extracellular Matrix;Failure;fluid flow;Foundations;Frequencies;Future;Heterogeneity;Human;Hydrogels;IGF2 gene;imaging Segmentation;In Vitro;in vivo;Individual;inhibitor;insight;Intervention;Kinetics;Label;Liver;Lung;Malignant Neoplasms;Matrix Metalloproteinases;Mediating;Metastatic Carcinoma;Microfluidic Microchips;Microfluidics;Microscopy;migration;Modeling;Motility;mouse model;mutational status;Neoplasm Metastasis;neoplastic cell;Nonmetastatic;Oncogenic;Organoids;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Pre-Clinical Model;pre-clinical research;preclinical study;Prediction of Response to Therapy;Primary Neoplasm;Proliferating;Property;Research;Resistance;Retinoblastoma Protein;Role;Sampling;Signal Pathway;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Site;Sorting;Survival Rate;System;targeted treatment;Technology;Therapeutic Intervention;therapeutic target;therapeutically effective;Time;Tissues;TP53 gene;transcriptomics;tumor;Tumor Cell Invasion;tumor heterogeneity;tumor progression;Work

PROJECT_TITLE: A matrix metalloproteinase biosensor-functionalized metastasis-on-a-chip platform for evaluating adrenocortical carcinoma progression


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Advanced age is the greatest risk factor for the onset and progression of Alzheimer's disease. We are using the powerful genetics of the fruit fly Drosophila to better understand the biological mechanisms of aging. The long-term goal of this research is to provide novel therapeutic targets to counteract age-related human diseases, including Alzheimer's disease.

PI_NAMEs: WALKER, DAVID W (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acids;Adult;Age of Onset;age related;age-related disease;aged;Aging;aging brain;aging mechanism;aging related;Agonist;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Animals;Autophagocytosis;Binding Proteins;Biological;Body System;Brain;Cell model;Cytosol;Deoxyribonucleases;Development;DNA;drivers of aging;Drosophila genus;effective therapy;Elderly;extend lifespan;fly;Genetic;genetic approach;Goals;hallmarks of aging;Health;healthspan;Homeostasis;HRK gene;immune activation;Immune signaling;Immune system;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Innate Immune System;Knowledge;Link;Lysosomes;Mammals;Mediating;Membrane Proteins;Mitochondria;mitochondrial autophagy;Mitochondrial DNA;mitochondrial dysfunction;Molecular;Nervous System;neuroinflammation;Neurons;new therapeutic target;NF-kappa B;novel therapeutic intervention;novel therapeutics;Onset of illness;Outer Mitochondrial Membrane;Pathogen detection;Pathogenesis;Pathology;Prevalence;prevent;Process;Reporting;Research;Research Design;Respiratory Chain;Risk Factors;Role;sensor;Signal Transduction;Stress;System;targeted treatment;Therapeutic Intervention;Tissues;Up-Regulation;Work

PROJECT_TITLE: Role of Mitochondrial Homeostasis in Animal Aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE: OVERALL There were an estimated 1.7 million new cases of cancer in the United States in 2018, and an estimated 609,000 deaths from the disease. Cancer is the second leading cause of the death in the U.S. The goal of the Fred Hutchinson/University of Washington Cancer Consortium is the elimination of cancer as a cause of suffering and death through more effective prevention, diagnosis, and treatment, deriving from fundamental insights into the biology of the disease.

PI_NAMEs: LYNCH, THOMAS JAMES (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Alaska;anti-cancer research;Area;base;Biology;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Detection;cancer diagnosis;Cancer Etiology;cancer therapy;carcinogenesis;Carcinogenesis Mechanism;Caregivers;Catchment Area;Cause of Death;Cessation of life;Child;Childhood;Clinical;clinical care;clinical practice;Clinical Research;Collaborations;Communities;Comprehensive Cancer Center;Computational Biology;computer studies;County;Development;Diagnosis;Diagnostic;Discipline;Disease;Educational process of instructing;Enrollment;Ensure;epigenomics;Equation;Equity;Exposure to;Faculty;Faculty Recruitment;Fostering;Funding;Genomics;Goals;graduate student;Grant;Health;Health Sciences;Hematopoietic Stem Cell Transplantation;host neoplasm interaction;Idaho;Immunology;Immunotherapeutic agent;improved;Individual;insight;Institution;inter-institutional;interdisciplinary collaboration;interest;Intervention;Investments;Knowledge;Laboratories;Laboratory Research;Leadership;Malignant Neoplasms;Measures;member;Mentors;Mission;Molecular;Montana;mortality;multidisciplinary;next generation;Outcome;outreach;pathogen;Patients;Peer Review;Population Research;Postdoctoral Fellow;Prevention;Prevention strategy;Primary Prevention;profiles in patients;programs;Public Health;Quality of Care;Research;Research Infrastructure;Research Personnel;Resources;Risk Factors;Risk Marker;Science;Secondary Prevention;Students;synthetic biology;targeted treatment;Therapeutic;therapy development;Training;Training and Education;Translating;Translational Research;Translations;Transplantation;treatment center;treatment trial;tumor;tumor metabolism;tumor progression;Underrepresented Populations;United States;Universities;Washington;Work;Wyoming

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


PHR: Not applicable to P30 CCSG as stated in the FOA PAR-17-095.

PI_NAMEs: LAW, WENDY  (contact)

PROJECT_TERMS: Administrator;anti-cancer research;Area;Attention;Cancer Center;Cancer Center Support Grant;career;Catchment Area;Clinical Trials;Collaborations;community engagement;Community Outreach;Data;design;Development;Ensure;Equity;equity, diversity, and inclusion;Evaluation;Faculty;Feedback;Funding;Goals;Grant;Guidelines;Heart;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;Intervention Trial;Journals;Leadership;Maintenance;Malignant Neoplasms;Measures;meetings;member;Mind;Monitor;mouse model;operation;Philanthropic Fund;pre-clinical;Process;programs;Publications;Recommendation;Research;Research Support;Resource Allocation;Resource Sharing;Resources;Science;Secure;Strategic Planning;success;symposium;Training and Education;tumor;underserved community;Universities;Vision;Washington;Work

PROJECT_TITLE: Cancer Center Administration


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Colorectal Cancer;Digestive Diseases;Prevention

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Colonoscopy is a common cancer screening procedure that is far from perfect and one of its major flaws is that the physician is unable to view large areas of the colon hidden behind folds, which leads to missed pre-cancerous growths and the unexpected, early development of cancer. We will develop and demonstrate a unique single viewpoint panoramic imaging technology which can be either integrated to the new colonoscope or added as an attachment to the standard colonoscopes, providing a wide-field forward view and 360-degree side-view. A more thorough colonoscopy will lead to fewer missed polyps, longer screening intervals, and a substantial reduction in the economic burden of colonoscopy

PI_NAMEs: LIANG, RONGGUANG  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Address;Adopted;Adoption;Algorithms;Area;burden of illness;Cancer Etiology;cancer prevention;Cessation of life;clinical practice;Colon;Colon Carcinoma;Colonoscopes;Colonoscopy;Color;Complex;contrast imaging;cost;Data Analyses;design;Detection;Development;Diamond;Economic Burden;Engineering;Evaluation;Excision;experience;fabrication;Goals;Growth;Image;image processing;imaging capabilities;imaging system;Imaging technology;improved;Incidence;lens;Lesion;Location;Malignant Neoplasms;men;Methods;Modeling;Morbidity - disease rate;mortality;novel;Optics;Patients;Performance;Physicians;Polyps;Precancerous Polyp;premalignant;prevent;Published Comment;screening;Screening for cancer;Screening procedure;Side;Societies;Surface;System;Time;Training;United States;Woman

PROJECT_TITLE: Single viewpoint panoramic imaging technology for colonoscopy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-P(81)S]


PI_NAMEs: SALAMA, NINA  (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;anti-cancer research;Award;Basic Science;Caliber;Cancer Center Support Grant;Cancer Research Project;career;Clinical;Clinical and Translational Science Awards;Clinical Trials;design;Development;Discipline;Doctor of Philosophy;Dryness;Education;Educational workshop;Epidemiology;experience;Exposure to;Faculty;faculty mentor;Fellowship;Future;Goals;graduate student;Grant;Hematology;high school;High School Faculty;High School Student;Individual;innovation;laboratory experience;Lead;Link;literacy;Malignant Neoplasms;Medical;Medical Genetics;Mentors;Mission;Molecular;Molecular and Cellular Biology;next generation;notch protein;Participant;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;programs;Research;Resources;School Teachers;Science;Scientist;Secondary Schools;skill acquisition;sound;Structure;Students;success;Talents;tool;Training;Training and Education;training opportunity;Training Programs;translational health science;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: Cancer Research Career Enhancement and Related Activities


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Metal–protein interactions are essential for the function of at least one-third to one-half of all proteins in cells. The incorrect binding of a metal to a protein, however, can lead to harmful effects on the cell, including toxicity. The research proposed here is designed to identify the protein targets of metal stress and elucidate molecular mechanisms that lead to toxicity. The outcomes will advance our understanding of how proteins across the proteome respond to exposure to excess levels of biologically relevant Zn and Cu, with important implications for developing pharmacological agents to leverage metal stress against microbial pathogens and cancer.

PI_NAMEs: FITZGERALD, MICHAEL C;FRANZ, KATHERINE J. (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Affect;anti-cancer;antimicrobial;Binding;Biological;Biological Assay;biophysical properties;Biophysics;cancer cell;Cancer cell line;Candida albicans;Cell Line;Cell Physiology;Cell Separation;Cell Survival;cell type;Cells;Chemicals;cofactor;Collaborations;Copper;Data;design;Development;Environment;Escherichia coli;Escherichia coli Proteins;Event;experience;Exposure to;Foundations;Functional disorder;Global Change;Goals;Growth;Homeostasis;Human;Immune system;In Vitro;Ionophores;Ions;Laboratories;Link;Location;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Metabolism;Metal exposure;Metalloproteins;Metals;Methodological Studies;Methods;microbial;Molecular;Monitor;Neurodegenerative Disorders;Nutrient;Nutritional Requirements;Organism;Outcome;Outcome Study;pathogen;pathogenic microbe;Pathway interactions;pharmacologic;Physiologic pulse;Precipitation;Predisposition;prostate cancer cell;protein folding;protein function;protein misfolding;Proteins;Proteolysis;Proteome;Proteomics;Proxy;Publishing;Research;Signal Transduction;Stress;Techniques;Testing;Therapeutic;Time;tool;Toxic effect;Trace Elements;trafficking;Translations;Work

PROJECT_TITLE: Elucidating the Molecular Basis of Cellular Metal Stress by using Mass Spectrometry-Based Proteomic Methods


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative The proposed research will develop a new catalytic strategy to selectively transform simple and inexpensive molecules into compounds of medicinal importance, such as pharmaceuticals. Ultimately, the proposed project will facilitate the development and large-scale preparation of new pharmaceuticals while simultaneously reducing the cost of life-changing medicines.

PI_NAMEs: WICKENS, ZACHARY KIMBLE (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Address;ALK Pathway;Alkali Metals;Alkenes;Anions;Biomedical Research;carbanion;carbonyl compound;Catalysis;catalyst;Chemistry;Chlorides;Climacteric;Collection;Complement;cost;Coupling;design;Development;drug discovery;Electrochemistry;Electron Transport;Electrons;Event;Exclusion;Family;Felis catus;Generations;Goals;Health;Human;Hydrogenation;In Situ;Ions;Ketones;Medicine;Methods;Modernization;Molecular Probes;next generation;Organic Synthesis;Outcome;Oxidation-Reduction;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Photons;Preparation;Reaction;Reagent;Reducing Agents;Research;Research Proposals;Role;System;Technology;Visible Radiation

PROJECT_TITLE: New precursors for diverse radical reactions enabled by potent photoreductants

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: VAZQUEZ-LOPEZ, JULIO  (contact)

PROJECT_TERMS: Acceleration;Address;Advisory Committees;anti-cancer research;Cancer Center Support Grant;Cell Physiology;Cellular Assay;cellular imaging;Complex;Computer software;Consultations;Contracts;cost;cost effective;Electron Microscopy;equipment acquisition;Faculty;Feedback;Financial Hardship;Fluorescence Microscopy;Future;Gel;Goals;Hour;Image;Image Analysis;imaging capabilities;imaging facilities;Immunofluorescence Immunologic;Immunohistochemistry;improved;Individual;innovation;Institution;instrument;instrumentation;Karyotype determination procedure;Leadership;Light;light microscopy;light transmission;live cell imaging;Maintenance;Malignant Neoplasms;member;Microscope;Microscopy;Minor;Mission;Modality;model organism;Modernization;Molecular;multiphoton microscopy;new technology;novel;operation;outreach;Penetration;performance tests;personalized approach;Preparation;programs;quantitative imaging;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;response;Sampling;satisfaction;Scanning;Scanning Electron Microscopy;Schedule;Scientist;screening;Seasons;Services;skills;Slide;Structure;Surveys;Techniques;Technology;technology/technique;Time;Tissues;tool;Tracer;Training;Transmission Electron Microscopy;trend;tumor immunology;ultra high resolution;Universities;Update;Vendor;Visualization;Washington;Work

PROJECT_TITLE: Shared Resource: Cellular Imaging


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: CHANTHAPHAVONG, RATSAMY SAVANH (contact)

PROJECT_TERMS: Antibodies;assay development;Biological Assay;Cancer Center Support Grant;cancer therapy;Complex;Consultations;cost;cost effective;Custom;density;design and construction;Detection;Development;digital imaging;DNA;experience;Experimental Designs;Fostering;Funding;Generations;Histopathology;Image;Image Analysis;Immunohistochemistry;improved;In Situ Hybridization;Individual;Industry Standard;innovation;laser capture microdissection;Learning;Malignant Neoplasms;Pathologic;Pathologist;Pathology;Phase;Phenotype;Process;Production;programs;quantitative imaging;Reagent;Research;Research Personnel;Resource Sharing;Resources;RNA;Scientist;screening;Services;Slide;Social Network;Tissue Microarray;Tissues;tool;Training;Translating;translational goal;tumor;Universities;Validation;Washington

PROJECT_TITLE: Shared Resource: Research Pathology


PI_NAMEs: DELROW, JEFFREY  (contact)

PROJECT_TERMS: Adopted;ATAC-seq;Atmosphere;Attention;Bar Codes;bead chip;Bioinformatics;Bioinformatics Shared Resource;Biological Assay;Biological Sciences;Cancer Center Support Grant;Caring;Chromium;Cleavage Under Targets and Release Using Nuclease;Collaborations;Communities;Creativeness;CRISPR/Cas technology;Data;Data Analyses;deep sequencing;Development;Dideoxy Chain Termination DNA Sequencing;digital;DNA-Protein Interaction;Education;Ensure;Environment;epigenomics;Equipment;exome sequencing;experience;Experimental Designs;Expression Profiling;Faculty;Feedback;Future;Generations;Genetic Fingerprintings;genome sequencing;Genomics;Genomics Shared Resource;Goals;graduate student;Growth and Development function;Hi-C;Housing;Individual;instrumentation;interest;Malignant Neoplasms;member;Messenger RNA;Methodology;Methods;methylome;MicroRNAs;nano-string;new technology;Peer Review;Persons;Phase;Postdoctoral Fellow;Publications;Reagent;Research;Research Personnel;Research Project Grants;Resource Sharing;Ribosomes;Sampling;Savings;Scientist;Seasons;Services;sound;Students;success;Sum;System;Targeted Resequencing;Technology;Time;Training;Training and Education;training opportunity;Transact;Transcend;trend;Universities;Untranslated RNA;Washington;whole genome;Work

PROJECT_TITLE: Shared Resource: Genomics & Bioinformatics


PI_NAMEs: GAFKEN, PHILIP R (contact)

PROJECT_TERMS: advanced analytics;Analytical Biochemistry;Analytical Chemistry;Area;Awareness;Bile Acids;Bioinformatics;Biological;Biological Assay;Cancer Biology;cancer care;Cancer Center Support Grant;cancer immunotherapy;Cancer Patient;cancer prevention;Chromatography;Clinical;Coenzymes;complex data;Consult;Consultations;cost effective;Data;Data Analyses;Dedications;design;Development;Digestion;Education;education resources;Educational Materials;Educational workshop;effective therapy;Equipment;experience;Experimental Designs;experimental study;Feedback;Fractionation;Future;Gel;General Population;Grant;High Pressure Liquid Chromatography;Human Resources;improved;Individual;Informatics;Infrastructure;instrument;interest;Isotopes;knowledge base;lipidomics;Lipids;liquid chromatography mass spectrometry;Liquid substance;Major Histocompatibility Complex;Malignant Neoplasms;Mass Fragmentography;Mass Spectrum Analysis;Measures;member;Metabolic;metabolic abnormality assessment;metabolomics;metabolomics resource;Methodology;Methods;Mission;Modernization;Modification;Molecular;new technology;NMR Spectroscopy;Nuclear Magnetic Resonance;operation;Pathway Analysis;Peptides;Policies;Post-Translational Protein Processing;Preparation;Process;Productivity;programs;Proteins;Proteomics;Proteomics Shared Resource;Research;Research Personnel;Research Support;Resource Sharing;Resources;response;Sampling;Services;skills;Slice;small molecule;stable isotope;Statistical Data Interpretation;statistics;symposium;Technology;Testing;Time;Tissues;tool;Tracer;Training;Training and Education;Translating;tumor immunology;Universities;Volatile Fatty Acids;Washington

PROJECT_TITLE: Shared Resource: Proteomics & Metabolomics


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: SWEDISH MEDICAL CENTER, FIRST HILL

PHR: PROPOSAL NARRATIVE Glioblastoma (GBM) is the most aggressive type of glioma, characterized by fast growth and poor prognosis, with an average survival of 15 months. Here we will apply a systematic molecular analysis to identify alternatively spliced genes in GBMs and then validate the biological function of those splice forms in patient- derived glioma stem cells. Our main goal is to identify putative alternative splicing genes as therapeutic targets for future studies in personalized medicine.

PI_NAMEs: COBBS, CHARLES S (contact);SEARLE, BRIAN CHIH-SENG

PROGRAM_OFFICER_NAME: GANGULY, ANIRUDDHA

PROJECT_TERMS: Affect;Alternative Splicing;Apoptosis;Awareness;biobank;Biological;Biological Assay;Biological Process;Biopsy;Biopsy Specimen;Brain;Brain Neoplasms;cancer survival;cancer type;candidate identification;Cell Separation;chemotherapy;Data;Development;diagnostic biomarker;differential expression;Event;Excision;Exons;experimental study;follow-up;Future;Genes;Genetic Transcription;Glioblastoma;Glioma;Goals;Growth;Invaded;Investigation;large scale data;Malignant - descriptor;Malignant Neoplasms;Mass Spectrum Analysis;Methodology;Methods;Molecular;Molecular Analysis;Molecular Weight;mRNA sequencing;neoplastic cell;new therapeutic target;Normal tissue morphology;novel;novel marker;novel strategies;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patients;Pattern;personalized medicine;potential biomarker;precision medicine;Process;Prognosis;protein folding;Protein Isoforms;Proteins;proteogenomics;Proteomics;public database;Radiation therapy;Research;Resolution;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA Splicing;Sampling;side effect;small hairpin RNA;Source;Spliced Genes;standard of care;stem cells;Survival Rate;Techniques;Technology;Testing;therapeutic target;Time;Tissues;Transcript;transcriptome sequencing;transcriptomics;translational study;tumor;Tumor Antigens;tumor initiation;Validation;Variant;variant detection;Western Blotting;Work

PROJECT_TITLE: Using proteogenomics to assess the functional impact of alternative splicing events in glioblastoma


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cardiovascular;Digestive Diseases;Hematology;Kidney Disease;Liver Disease;Nutrition

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Iron deficiency and inflammation are major stimulators of FGF23 production and FGF23 cleavage. In diseases associated with impaired FGF23 cleavage, such as CKD, iron deficiency and inflammation contribute to disproportionately and extremely elevated levels of circulating intact FGF23 compared to the levels of FGF23 cleaved peptides, which directly leads to adverse cardiovascular outcomes. This project proposes to investigate the function of C and N terminal FGF23 peptides as key regulators of iron metabolism, erythropoiesis and cardiac remodeling, providing novel therapeutic targets to improve outcomes related to FGF23 perturbations in patients with CKD.

PI_NAMEs: DAVID, NICOLAE VALENTIN (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Acute;adverse outcome;Anemia;Animals;Bilateral;Binding;Biological Availability;bone;Brucella abortus;C-terminal;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;Cell Differentiation process;Cell Maturation;Cell secretion;Chronic;Chronic Kidney Failure;Circulation;Consensus;Coupled;Coupling;Data;dentin matrix protein 1;design;Development;Diet;Disease;disease model;Disease Outcome;Erythroid;Erythroid Cells;erythroid differentiation;Erythropoiesis;Erythropoietin;fibroblast growth factor 23;Fibroblast Growth Factor Receptors;General Population;Genetic;Genetic Transcription;Goals;Heart Hypertrophy;Hepatic;Hepatocyte;hepcidin;Homeostasis;Hormone secretion;Hormones;Impairment;improved;improved outcome;In Vitro;in vivo;Inflammation;Inflammatory;innovation;inorganic phosphate;insight;Interleukins;Iron;iron deficiency;Iron deficiency anemia;iron metabolism;Iron Overload;Kidney;Lead;Left Ventricular Hypertrophy;Length;Liver;Mediating;Metabolism;Modeling;Molecular;Morphology;mortality;mouse model;Mus;Muscle Cells;N-terminal;neonatal mice;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Osteoblasts;Osteocytes;Outcome;overexpression;Pathologic;Patients;Peptides;pharmacologic;Physiological;prevent;Production;Proteins;Regulation;Renal function;Reperfusion Injury;Resistance;response;Role;Signal Transduction;Slice;Source;Supplementation;Surgical Models;Testing;Therapeutic;therapeutic evaluation;Ventricular

PROJECT_TITLE: Role of FGF23 peptides in chronic kidney disease (CKD)

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Cancer;Hematology;Infectious Diseases;Radiation Oncology;Rare Diseases

PI_NAMEs: ROBLE, GORDON  (contact)

PROJECT_TERMS: Acceleration;Accreditation;Animal Cancer Model;animal care;animal colony;animal facility;Animal Housing;Animal Husbandry;Animal Model;Animals;Area;bioimaging;Biological;Bone Marrow Transplantation;Breeding;Cancer Center Support Grant;canine model;Canis familiaris;Caring;Cavia;Clinical;Collaborations;Communication;Communities;comparative;Comparative Pathology;Complex;Consultations;Control Animal;Dedications;Disease;Electronic Mail;Equipment;Event;Fishes;Gene Modified;Genetic Diseases;Genetic Models;Goals;graft vs host disease;Hematologic Neoplasms;Housing;Human Resources;humanized mouse;IACUC;Immunodeficient Mouse;Immunotherapy;improved;Individual;Infectious Agent;infectious disease model;Information Services;Infrastructure;Laboratory Animal Medicine;Linear Accelerator Radiotherapy Systems;Liquid substance;Lymphoma;Malignant Neoplasms;medical specialties;Medicine;meetings;member;Methods;model development;Modeling;Mus;Newsletter;Nobel Prize;Online Systems;Operative Surgical Procedures;outreach;pathogen;Pathologist;patient derived xenograft model;Pre-Clinical Model;pre-clinical research;preclinical imaging;preclinical study;Procedures;programs;protocol development;pyruvate kinase deficiency;Radiation therapy;Radioactive;Rattus;Regulation;Research;Research Activity;Research Personnel;Research Support;Resource Sharing;Resources;Rodent;Rodent Model;Services;Severe Combined Immunodeficiency;skills;Solid Neoplasm;Structure;Technology;translational health science;Translational Research;Transplantation;United States Department of Agriculture;Update;ventilation;Veterinarians;web site;Work

PROJECT_TITLE: Shared Resource: Comparative Medicine


PI_NAMEs: CAO, JIANHONG  (contact)

PROJECT_TERMS: Adherence;Advisory Committees;antigen-specific T cells;Biological Assay;Biology;Cancer Center Support Grant;cancer immunotherapy;Cell Physiology;Cells;Clinical;Clinical Immunology;Clinical Research;Clinical Trials;Communicable Diseases;Communities;Complex;Custom;cytokine;Data;Data Set;Development;engineered T cells;Equipment;Evaluation;Experimental Designs;Faculty;Feedback;Flow Cytometry;Flow Cytometry Shared Resource;Funding;Goals;Group Meetings;Immune;Immune response;Immunologic Monitoring;Immunotherapy;immunotherapy trials;improved;Individual;Institution;instrument;instrumentation;Laboratory Research;Laboratory Study;laser cell sorter;Lasers;Maintenance;Major Histocompatibility Complex;Malignant Neoplasms;Manufacturer;Measures;meetings;member;Molecular;Monitor;Patients;Peptides;Personal Satisfaction;Phenotype;Procedures;Proteins;Protocols documentation;Qualifying;Reagent;Reproducibility;Research;Research Personnel;research study;Resource Sharing;Sampling;Services;Shapes;skills;Staff Development;Surveys;symposium;T-Lymphocyte;Technology;technology platform;Therapy trial;Training;Transplantation;tumor immunology;Universities;vaccine development;Washington;Work

PROJECT_TITLE: Shared Resource: Immune Monitoring & Flow Cytometry


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Nanotechnology;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Trauma is the leading cause of death and disability in the United States for people under the age of 45, and the current clinical management of complex extremity trauma is associated with high rates of complication, repeated hospitalizations, and permanent disability. Advancements in the treatment and functional restoration of composite bone-muscle traumas are hindered by the lack of available therapies that can repair both of these tissues together. Our research will guide the development of highly regenerative materials that work in concert with the body's healing programs and physical rehabilitation to restore the structure-function relationship within and between damaged muscle and bone with the potential to improve treatments for extremity trauma.

PI_NAMEs: NAKAYAMA, KARINA  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Aerobic Exercise;Affect;Age;angiogenesis;Anisotropy;Biophysics;Blood flow;bone;bone healing;bone marrow mesenchymal stem cell;Bone Regeneration;bone repair;Bone Tissue;Cause of Death;cell fate specification;Cells;Clinical;Clinical Management;Clinical Treatment;collagen scaffold;comorbidity;Complex;Complication;composite restoration;Coupled;Coupling;Cues;Defect;Dependence;Deposition;Development;disability;Endothelial Cells;Evaluation;examination questions;Exercise;Exercise Therapy;Extracellular Matrix;Fracture;Functional Regeneration;functional restoration;Gait;Gene Expression;Generations;Genomics;Guided Tissue Regeneration;healing;Hospitalization;improved;In Vitro;in vivo;Individual;Inflammatory;Injury;injury and repair;innovation;Lifelong disability;limb amputation;limb injury;Limb Salvage;Limb structure;Lower Extremity;Maintenance;mechanical load;Mediating;microCT;Mimetic Muscles;mimetics;Motion;mouse model;Mus;Muscle;Muscle Cells;Muscle Fibers;muscle physiology;muscle regeneration;Musculoskeletal;myogenesis;nanofibrillar;nanoscale;Natural regeneration;nerve supply;novel;Open Fractures;Operative Surgical Procedures;Osteoblasts;Osteogenesis;osteogenic;Outcome;paracrine;Pathway interactions;Pattern;Persons;Phenotype;Physical Rehabilitation;Physical therapy;Play;Production;progenitor;programs;Proteins;Proteome;radiological imaging;Recovery;Recovery of Function;regeneration potential;regenerative;regenerative approach;Regenerative engineering;Regimen;Regulation;Rehabilitation therapy;reinnervation;repaired;Research;Resistance;Role;Running;scaffold;Series;severe injury;Site;Skeletal Muscle;Skeletal system;soft tissue;Stains;Structure-Activity Relationship;Surgical Management;System;tibia;tibialis anterior muscle;tissue regeneration;Tissues;Transplantation;Trauma;United States;War;Work

PROJECT_TITLE: Regenerative engineering for complex extremity trauma