ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Breastfeeding, Lactation and Breast Milk;Cancer;Nutrition;Prevention;Women's Health Research

ORG_CITY: POTSDAM

ORG_NAME: CLARKSON UNIVERSITY

PHR: Program Director/Principal Investigator (Last, First, Middle): Darie, Costel C. Project Narrative (Public Health Relevance) This study will broaden the understanding of the biochemical (protein based) changes in breast milk that are specific to breast cancer (BC). The translation of the proteomic signature from a local microenvironment (breasts) to a systemic environment (blood) will then allow its use in detection of BC in non-lactating women. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: DARIE, COSTEL C. (contact)

PROGRAM_OFFICER_NAME: FU, SIDNEY WANG

PROJECT_TERMS: Address;Age;Area;Arginine;Biochemical;Biochemical Pathway;Bioinformatics;biomarker signature;Blood;Breast;Breast Cancer Detection;Breast Cancer Early Detection;Breast Cancer Prevention;breast cancer progression;Breast Cancer Risk Factor;C-terminal;career;Charge;Chromatography;Collection;Complement;Detection;detection method;Development;Diagnosis;Diagnostic;ductal breast carcinoma;Early Diagnosis;Early Intervention;Early treatment;Environment;epidemiology study;Fibrinogen;Funding;Goals;Grant;Growth;Health;Human Milk;Individual;infiltrating duct carcinoma;Learning;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Medical;Methods;Milk;Milk Proteins;mortality;multiple reaction monitoring;Natural Source;Outcome;parent grant;parent project;Pathway interactions;Peptides;Population;Post-Translational Protein Processing;Predisposition;Premenopause;Preventive treatment;Primary Prevention;Principal Investigator;Process;programs;protein degradation;protein function;Protein Truncation;Proteins;proteomic signature;Proteomics;public health relevance;reproductive;Research;Risk;Role;Sampling;Serum;Serum Proteins;Set protein;Source;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;tandem mass spectrometry;tool;Training;translational proteomics;Trypsin;undergraduate student;Woman;Women's Group;young woman

PROJECT_TITLE: PA-23-189 for Kaya Johnson to CA260126-01: Identifying a proteomic signature for breast cancer detection in breast milk and serum


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative Tau tangles in Alzheimer's disease are associated with cognitive impairment, but some patients are resilient to this pathology. We aim to understand why and how tau pathology affects brain networks, which is crucial for developing effective treatments for high-risk patients. Using tau positron emission tomography and functional magnetic resonance imaging, we will determine the relationship between network architecture and cognitive decline in a diverse sample of participants at risk for Alzheimer's disease.

PI_NAMEs: VISSCHER, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Affect;African American;aged;Alabama;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Area;Atrophic;Attention;Auditory;auditory stimulus;Behavior Therapy;Black race;Blood;Brain;cerebral atrophy;Clinical;clinical diagnosis;Cognition;Cognitive;cognitive neuroscience;cognitive performance;cohort;Cohort Studies;comorbidity;Data;Data Set;Dementia;Deposition;effective therapy;Etiology;executive function;experience;Failure;flexibility;Functional Magnetic Resonance Imaging;Goals;Health;Hearing Tests;high risk;Impaired cognition;Impairment;Individual;Individual Differences;Knowledge;Language;Location;Long-Term Effects;Magnetic Resonance Imaging;Measures;Memory;Methods;mild cognitive impairment;multimodality;network architecture;neural;neural network;Neurofibrillary Tangles;neuroimaging;Neurons;Neuropsychological Tests;novel;Participant;Pathology;Patients;Pattern;Performance;Persons;Population;Population Heterogeneity;Positron-Emission Tomography;Prevalence;prevent;recruit;Research;resilience;response;Rest;Role;Sampling;segregation;Sensory;Sensory impairment;sensory stimulus;Signal Transduction;Spatial Distribution;System;tau Proteins;Testing;Time;tool;Training;Universities;Variant;Vision;Visual;Visual attention;visual stimulus;Work

PROJECT_TITLE: A multimodal examination of functional network health and its relationship with tau deposition

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE Aging is the strongest individual risk factor for Alzheimer’s disease and related dementias (ADRD). Preclinical data suggest that modifying biological aging pathways as well as the underlying cellular and molecular processes, the so-called hallmarks of aging, may slow or halt age-related chronic diseases including ADRD. Leveraging our novel geroscience-guided studies of biological aging pathways and aging hallmarks in older adults treated with metformin vs. placebo for frailty prevention, our study will expand our understanding of the role that specific biological aging processes exert on ADRD pathophysiology and determine whether targeting the biology of aging with metformin can modulate ADRD markers.

PI_NAMEs: ESPINOZA, SARA ELYSE (contact);GONZALES, MITZI MICHELLE;MUSI, NICOLAS

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Affect;Age;age acceleration;Age of Onset;age related chronic disease;age-related disease;Aging;aging mechanism;aging process;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Apolipoprotein E;Attenuated;Autophagocytosis;axon injury;Behavioral;Biological;Biological Aging;Biology of Aging;Cell Aging;Cognition;Data;Dementia;deregulated nutrient-sensing;disability;Disease;Disease Progression;disorder risk;Epigenetic Process;Ethnic Origin;Etiology;Female;frailty;FRAP1 gene;functional decline;Functional disorder;Genetic;Geroscience;Glial Fibrillary Acidic Protein;glucose metabolism;Goals;hallmarks of aging;healthspan;Hispanic;human old age (65+);improved;Individual;Inflammation;Intervention;life span;Light;Link;Mediation;Metabolic;Metabolism;Metformin;Mitochondria;mitochondrial dysfunction;Modification;Molecular;Morbidity - disease rate;mortality;mTOR inhibition;Neurodegenerative Disorders;neurofilament;neuroinflammation;Neurons;neuropathology;novel;novel strategies;older adult;participant enrollment;Pathology;Pathway interactions;Placebos;Plasma;Platelet-Derived Growth Factor;pleiotropism;pre-clinical;Prediabetes syndrome;Prevalence;prevent;Prevention;Process;randomized trial;randomized, clinical trials;rate of aging;Regulation;Research;response;Risk Factors;Role;senescence;sex;socioeconomic disparity;tau-1;Testing;therapeutic development;therapeutic target;Tissues;Translating;United States;Vascular Diseases

PROJECT_TITLE: Targeting Biology of Aging Mechanisms Underlying Alzheimer's Disease Risk with Metformin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-W (02)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Traumatic Head and Spine Injury

ORG_CITY: DALLAS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Regeneration and re-innervation of retinal ganglion cell (RGC) axons are generally limited after injury in adult mammals. In this study, we will concurrently use single cell imaging and single nucleus RNA sequencing to elucidate the molecular factors that underlie the regenerative failure.

PI_NAMEs: PARK, KEVIN KYUNG  (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: 3-Dimensional;Adopted;Adult;assault;Axon;axon injury;axon regeneration;Brain;Cell Nucleus;cell type;Cells;cellular imaging;Central Nervous System;central nervous system injury;Ciliary Neurotrophic Factor;Confocal Microscopy;Disease;experimental study;Eye Injuries;Failure;Fluorescence Microscopy;Freezing;Future;Genes;Genetic Transcription;Goals;Heterogeneity;Imaging Techniques;Immunoprecipitation;improved;in vivo;injured;Injury;insight;Investigation;Label;Laboratories;Lesion;Light;Mammals;Masks;Mechanics;Methodology;Molecular;Mus;Natural regeneration;Nerve Degeneration;neuronal cell body;Optic Nerve;optic nerve disorder;Optics;Organ;overexpression;Population;Proteins;Protocols documentation;receptor;reconstruction;Recovery of Function;regenerative;Regenerative capacity;reinnervation;repaired;Reporting;Resistance;response;Retina;retinal axon;retinal ganglion cell regeneration;Retinal Ganglion Cells;screening;Shapes;single nucleus RNA-sequencing;single-cell RNA sequencing;Solvents;Stains;syndecan;Techniques;Testing;THBS1 gene;Three-Dimensional Imaging;three-dimensional visualization;Thrombospondins;Time;Tissues;transcriptome sequencing;transcriptomics;Trauma;Travel;unpublished works;Vision;Visualization

PROJECT_TITLE: 3D visualization and Investigation of Retinal Axon Regeneration

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hypertension;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The goal of this project is to conduct mentoring and research that is patient oriented, sustainable, and focused on the clinical epidemiology and health disparities of cardiovascular diseases and hypertension. Dr. Anderson will leverage a strong track record of successful mentoring and research to recruit and train a diverse group of early career scientists, and strengthen her research portfolio for greater impact on global policy and advocacy.

PI_NAMEs: ANDERSON, CHERYL ANN MARIE (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Address;Adult;Advocacy;Affect;American;Area;Award;Black American;Black Populations;California;Cardiac Death;Cardiology;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder prevention;cardiovascular health;cardiovascular risk factor;career;Clinical;clinical epidemiology;Clinical Investigator;Clinical Research;Clinical Trials;cohort;Creativeness;culturally appropriate intervention;design;Development;Diet;Dietetics;Discipline;early-career faculty;Economic Burden;economic cost;Eligibility Determination;Environment;Epidemiology;epidemiology study;Equity;ethnic disparity;ethnic diversity;Ethnic Origin;Funding;Goals;Grant;Health;Health behavior;health disparity;health equity;Health equity research;health inequalities;healthy lifestyle;high risk population;Human;Hypertension;improved;Individual;Institution;Internal Medicine;Intervention;Laboratories;Leadership;lifestyle factors;Longevity;Low income;marginalization;marginalized community;Mentors;Mentorship;Methodology;Mid-Career Clinical Scientist Award (K24);Morbidity - disease rate;mortality;multidisciplinary;Neighborhoods;Nephrology;next generation;novel;nutrition;Observational epidemiology;Outcome;patient oriented;Physicians;Policies;Population;Postdoctoral Fellow;preservation;Prevention approach;programs;Public Health;Public Health Schools;Qualifying;racial disparity;racial diversity;racial health disparity;recruit;Research;Research Methodology;Research Peer Review;Research Personnel;Research Support;Resources;Rural Community;Science;Scientist;skill acquisition;skills;social factors;Structure;Time;Training;training opportunity;Translational Research;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Research and Mentoring in the Clinical Epidemiology and Health Disparities of Cardiovascular Diseases and Hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M3)]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Nanotechnology;Natural Products;Neurosciences;Pain Research

ORG_CITY: TUSCALOOSA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

PHR: PROJECT NARRATIVE We propose to develop a tetrodotoxin-based local anesthetic to treat post-operative or chronic pain. Such local anesthetic preparation can produce a duration of local anesthesia reliably lasting 7-14 days from a single perineural injection or site infiltration, and has minimal local or systemic side effects.

PI_NAMEs: ZHAO, CHAO  (contact)

PROGRAM_OFFICER_NAME: JETT, DAVID ALAN

PROJECT_TERMS: Address;Adjuvant;Adverse effects;Amides;Anesthetics;Arrhythmia;Biological Availability;biomaterial compatibility;Buffers;Bupivacaine;Cardiovascular system;Catheters;Chemicals;chronic pain;Clinical;clinical efficacy;Clinical Trials;clinically significant;controlled release;Development;Diameter;Dose;Drug Kinetics;efficacy evaluation;Enhancers;Esters;ethylene glycol;Feasibility Studies;Formulation;Glycolic-Lactic Acid Polyester;Goals;Hour;Hydrolysis;hydrophilicity;improved;in vivo;in vivo evaluation;Infiltration;Infiltration Anesthesias;Inflammation;Injections;Integrated Delivery Systems;Kinetics;Ligation;Light;lipophilicity;liposomal formulation;Liposomes;Local anesthesia;Local Anesthetics;Measures;Meta-Analysis;Modeling;Molecular Weight;Morbidity - disease rate;Motor;Movement;Muscle;Muscle Weakness;nanoparticle;Nerve;Nerve Block;Neurologic;neurotoxicity;Operative Surgical Procedures;Outcome;Pain;Pain management;pain score;Penetration;perineural;Perineuriums;Peripheral Nerves;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phenotype;Plasma;poly(D,L-lactide-co-glycolide);poly(glycerol-sebacate);Polymers;Postoperative Pain;Postoperative Period;Preparation;prospective;Rattus;Reaction;Reporting;Research;Respiratory Failure;Respiratory Paralysis;Risk;Safety;sciatic nerve;Seizures;Sensory;side effect;Silicon Dioxide;Site;Sodium Channel Blockers;Stimulus;Surgical incisions;System;systemic toxicity;Technology;Tetrodotoxin;Time;Tissues;Touch sensation;Toxic effect;uptake;wound

PROJECT_TITLE: Nanoparticles with Two-Stage Delivery of Tetrodotoxin for Prolonged Duration Local Anesthesia

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: The suicide rate among female Veterans is a growing concern, yet very little research has sought to understand how to alleviate risk among this group. As such, we know surprisingly little about the health and psychosocial experiences, healthcare utilization, or barriers to care for female Veterans at risk for suicide. By interviewing Veterans about their lived experiences with suicidal thoughts, suicide attempts, and recovery needs, we will begin to develop an understanding of female Veterans' risk. Then, we will follow a large cohort of female and male Veterans over time to develop and test an explanatory model of female Veterans' risk. Findings from this study will reveal which health and psychosocial experiences are predictive of suicide attempts among female Veterans as well as which healthcare services and barriers to care require attention, providing much-needed evidence to guide the selection of intervention targets and direct valuable suicide prevention resources.

PI_NAMEs: DENNESON, LAUREN M (contact)

PROJECT_TERMS: Address;administrative database;Attention;barrier to care;Biological;Caring;cohort;coping;Coping Skills;cost;Cross-Sectional Studies;Data;data warehouse;Development;Diagnosis;Distal;Distress;Enrollment;Event;evidence base;experience;falls;Feeling;Feeling suicidal;Female;follow-up;Gender;gender difference;Gender Role;Goals;Health;health care service;health care service utilization;Healthcare;Healthcare Systems;high risk;high risk population;High Risk Woman;interpersonal conflict;Intervention;Interview;Lived experience;Longitudinal cohort study;Longitudinal Studies;Longitudinal Surveys;male;Measures;Mediating;Medical Records;Mental Depression;Mental Health;Methodology;Methods;Military Personnel;military veteran;Modeling;Occupational;Participant;Patient Self-Report;Pattern;Population;Prevention approach;primary outcome;Process;psychosocial;Psychosocial Factor;Public Health;Questionnaires;Recording of previous events;Recovery;Reporting;Research;Research Priority;Resources;response;Risk;Risk Factors;Sample Size;Sampling;Self Direction;Services;sexual trauma;social;Socialization;Source;Stress;stressor;Substance Use Disorder;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surveys;Symptoms;Testing;Theoretical model;theories;Time;Transcript;Trauma;Veterans;Violence;women versus men;Women's cohort;women's prevention;Women's study;Work

PROJECT_TITLE: Advancing Suicide Prevention for Female Veterans

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Neurofibromatosis;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Neurofibromatosis is a cancer predisposition syndrome where numerous tumors form across the body which result from somatic mutations that accumulate throughout life. Though the specific mutations that cause tumors in neurofibromatosis have been well studied, the overall dynamics of somatic mutations remain unclear. This proposal leverages innovative technology to identify somatic mutations in single cells to better understand the genetic mechanisms that drive the pathogenesis of neurofibromatosis.

PI_NAMEs: SNELLINGS, DANIEL  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Address;Adult;Age;Area;Attention;autism spectrum disorder;Automobile Driving;autosome;biobank;Biological Assay;Brain;brain control;cancer predisposition;Cell Nucleus;cell type;Cells;Central Nervous System;Characteristics;Child;Childhood;Chromosomal Rearrangement;cognitive function;Copy Number Polymorphism;Data;Deamination;DNA;driving force;executive function;Foundations;Freezing;Future;gamma-Aminobutyric Acid;Genes;Genetic;genome sequencing;genome-wide;Glioma;Heterozygote;Human;Impaired cognition;Impairment;Individual;inhibitory neuron;innovative technologies;insight;Intellectual functioning disability;Knowledge;Lead;Life;Loss of Heterozygosity;Mediating;Memory impairment;Methods;mosaic variant;Mosaicism;mouse model;Mus;Mutagenesis;Mutation;Mutation Analysis;Mutation Spectra;neoplastic cell;Nervous System Disorder;neurobehavioral;Neurofibromatoses;Neurofibromatosis 1;Neuroglia;Neurologic Deficit;Neurons;NF1 gene;Oligodendroglia;Oncogenes;Pathogenesis;Pattern;Perception;Peripheral Nervous System;Phenotype;Predisposition;Preparation;Role;Sampling;Schizophrenia;Somatic Mutation;Syndrome;Testing;tumor;United States National Institutes of Health;Variant;whole genome;Work

PROJECT_TITLE: Investigating the Role of Somatic Mutations in Neurofibromatosis Brain


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: DETROIT

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Our goal is to improving treatment options and lifespan of women with metastatic breast cancer by improving the understanding of the molecular co-evolution of the tumors and the immune system during tumor development and progression. Our expected outcomes include; 1) advancing our current understanding of resistance mechanisms; 2) determining how stress-induced HSP?0 may regulate immunosuppression; and 3) testing the therapeutic utility of HSP?0 inhibitor to improve effectiveness of current therapies in metastatic breast cancer. Our impact includes the identification of molecular targets that regulate critical steps in metastatic process and will lead to improved therapeutic approaches for the treatment of women with metastatic disease.

PI_NAMEs: KORKAYA, HASAN  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Administrative Supplement;Aggressive behavior;anti-tumor immune response;Antitumor Response;Binding;Biological Assay;cancer cell;cancer stem cell;cancer subtypes;Cell Death;Cell Death Induction;Cells;chemotherapy;Clinical;Clinical Data;Clinical Research;clinically relevant;Communication;CSF3 gene;cytokine;Cytokine Activation;Cytoprotection;Cytotoxic agent;Cytotoxic T-Lymphocytes;Data;Development;Disease;Disease Progression;Effectiveness;epithelial to mesenchymal transition;Epithelium;Generations;Goals;granulocyte;Heat-Shock Proteins 70;IL6 gene;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunosuppression;Immunotherapy;improved;In Vitro;Inflammatory;inhibitor;Interleukin-1 beta;Knockout Mice;life span;Literature;Macrophage;Malignant Breast Neoplasm;Mediating;Mesenchymal;Metastatic breast cancer;metastatic process;Molecular;Molecular Target;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;neutrophil;Outcome;Pathway interactions;Patients;permissiveness;Phenotype;Play;pre-clinical;Process;Production;Prognosis;Progressive Disease;Property;Publishing;Research;resistance mechanism;response;Role;Sampling;Signal Transduction;Site;standard of care;Stress;Stromal Cells;Testing;Therapeutic;therapeutic evaluation;therapy resistant;Toll-like receptors;Transactivation;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-Derived;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Woman;women's outcomes;women's treatment;Work

PROJECT_TITLE: Administrative Supplement to Dual function of HSP70 in cytoprotection of tumor cells and generation of permissive microenvironment

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Every day, 50.1 million children ages 5 to 18 years attend grades K-12. About 27% of those children suffer from at least one medical condition requiring them to take medication at school. Up to 48% of school nurses reported that they made a medication administration error at school. In this study, we will be implementing a technology, similar to the one used in hospitals, to reduce medication errors at schools.

PI_NAMEs: FARAG, AMANY  (contact)

PROGRAM_OFFICER_NAME: SAMAD, FARZANA

PROJECT_TITLE: Assuring Medication Safety in K-12 Schools: Implementing and Evaluating the Electronic School Medication Administration Record (E-SMAR) System

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Behaving adaptively in our environment requires retrieving the information about past experiences that is most relevant to our current goals. This project uses empirical and computational modeling methods to examine how memory and control areas of the brain interact to support this adaptive retrieval process. A detailed understanding of these mechanisms could suggest new targets for intervention in mental health disorders such as depression and schizophrenia with disturbances to memory processes.

PI_NAMEs: SCHAPIRO, ANNA C (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TITLE: Learning novel structure across time and sleep

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infectious Diseases;Microbiome

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative In the United States, one in four adults has an active cavity, and of adults over 65, one in four has fewer than nine teeth. While oral health and the oral microbiome that supports it are both highly heritable, few genetic associations have been established. This project aims to better characterize genetic variation at the salivary amylase locus to identify any associations it has with oral health phenotypes as well as the prevalence of specific bacterial species in the oral microbiome that are known to impact tooth health.

PI_NAMEs: KAMITAKI, NOLAN  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Adhesions;Adult;Affect;Amylases;Automobile Driving;Bacteria;Binding;biobank;cohort;Complex;Computing Methodologies;Conflict (Psychology);Coupled;Data;Data Set;Decayed, Missing, and Filled Teeth;Dental;Dental caries;Dental Hygiene;Dental Plaque;Dentures;Diet;Digestion;Environmental Risk Factor;Enzymes;experience;feeding;Gene Dosage;Genes;Genetic;genetic association;genetic variant;Genetic Variation;genome wide association study;Genomic Segment;Genotype;Growth;Haplotypes;Health;Hemorrhage;Heritability;Hour;Human;Human Genome;Impacted Tooth;improved;Incidence;Individual;infancy;inter-individual variation;Intestines;Knowledge;large datasets;Life;Link;Linkage Disequilibrium;Maps;Measures;Metabolism;Methods;microbiome;Modernization;older adult;oral bacteria;Oral cavity;oral commensal;Oral health;oral microbiome;Pancreas;Pathway interactions;Persons;Phenotype;Play;Population;Prevalence;Prevotella;Process;Pseudogenes;Role;saliva sample;Salivary;Sample Size;Sampling;scale up;Sequence Homology;Signal Transduction;Standardization;Starch;Streptococcus gordonii;Streptococcus mutans;Structure;sugar;Techniques;Time;Tooth structure;tooth surface;United States;Update;Variant;Work

PROJECT_TITLE: Characterizing structural variation at the amylase locus influencing oral health

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: GAINESVILLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The primary mission of our Wellstone Center is to understand the molecular and physiological events that lead to the most common form of adult-onset muscular dystrophy, myotonic dystrophy, and utilize this knowledge to develop safe and effective treatments for this disease. Our Center organization, which includes the National Registry for myotonic dystrophy, is built on close and long-standing collaborations with basic researchers at the University of Florida and clinical experts at the University of Rochester.

PI_NAMEs: SWANSON, MAURICE SCOTT (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Acceleration;ACTA1 gene;Actins;Address;Adult;Age;Bacterial Artificial Chromosomes;Basic Science;Biological;Biological Markers;Characteristics;Clinical;Clinical assessments;clinical development;Clinical Investigator;Clinical Sciences;Clinical Trials;cohort;Collaborations;Communication;Communities;Competence;Data;data sharing;Defect;deltoid muscle;design;Development;Disease;DNA Library;Dryness;Early treatment;effective therapy;Enrollment;Event;Facioscapulohumeral Muscular Dystrophy;Family member;Florida;Funding;Future;gain of function;Generations;genetic analysis;Genetic Determinism;genetic disorder diagnosis;Geography;Histologic;Human;in vivo;Information Technology;Infrastructure;intergenerational;International;Interruption;Introns;Knock-in;Knockout Mice;Knowledge;Leadership;Length;Life Cycle Stages;Link;member;Messenger RNA;Metabolism;Methodology;Mission;Modeling;Molecular;Molecular Disease;Monitor;mouse model;Muscle Weakness;Muscular Dystrophies;Myotonic Dystrophy;Myotonic dystrophy type 1;Natural History;next generation;Nuclear RNA;Pathologic;Patient Recruitments;Patients;Peptides;performance site;Phase;Physiological;Productivity;Proteins;Recording of previous events;recruit;Registries;remediation;remote assessment;Reporting;Research;Research Design;Research Personnel;Resource Sharing;Resources;RNA;RNA Processing;RNA Splicing;Role;Scientist;Severities;Severity of illness;sex;Site;Skeletal Muscle;skills;Statistical Models;Structure;synergism;targeted treatment;Telemedicine;Testing;Therapeutic;Toxic effect;Training;Transgenes;Transgenic Mice;Transgenic Model;Transgenic Organisms;translational study;Translations;Universities;Variant

PROJECT_TITLE: Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-L (55)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Orphan Drug;Rare Diseases

PROJECT_TERMS: Academia;Acceleration;Address;Adherence;Adult;Advisory Committees;Advocacy;advocacy organizations;Advocate;Affect;Animal Model;Animal Welfare;Artificial Intelligence;Basic Science;Biocompatible Materials;Biotechnology;Budgets;care providers;Clinical;Clinical Management;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;collaborative environment;Communication;Communities;Community Physician;COVID-19 pandemic;Data;Data Collection;data sharing;design;Diagnosis;Disease;Education;Education and Outreach;Educational Models;effective therapy;Electronics;Enrollment;Family;Family member;Fellowship Program;Florida;Fostering;Foundations;Functional disorder;Funding;Genes;Goals;Guidelines;Hereditary Disease;Human Resources;human subject;IACUC;improved;Individual;Information Technology;Infrastructure;Institution;Institutional Policy;interest;International;Investigational Therapies;Lead;Leadership;Location;material transfer agreement;Medical center;meetings;Mission;Monitor;Muscular Dystrophies;Mutation;Myotonic Dystrophy;neurogenetics;Neurology;Newsletter;novel;outreach;Patient advocacy;Patients;Pharmacologic Substance;Positioning Attribute;Principal Investigator;Printing;Privacy;Procedures;Publications;recruit;Regulation;Reporting;Research;Research Design;Research Personnel;Resource Sharing;Resources;Safety;Scientist;Short Tandem Repeat;social media;Structure;symposium;Tandem Repeat Sequences;Therapeutic;therapeutic development;Training and Education;Translational Research;transmission process;Travel;United States National Institutes of Health;Universities;Untranslated RNA;virtual;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Facioscapulohumeral Muscular Dystrophy;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Orphan Drug;Rare Diseases;Urologic Diseases;Women's Health Research

PI_NAMEs: HAMEL, JOHANNA  (contact)

PROJECT_TERMS: Abdomen;Address;Affect;Age;Area;autosome;Biological;Bladder;burden of illness;Characteristics;Clinic;Clinical;clinical care;Clinical Data;clinical predictors;Clinical Research;Clinical Trials;Communication;Communities;Community Health Education;Community Outreach;comparative effectiveness;Comparative Study;Data;data access;Data Collection;data registry;Data Reporting;Data Set;Development;Disabling;Disease;Disease Progression;efficacy trial;Enrollment;Facioscapulohumeral Muscular Dystrophy;Family;Family member;Family Study;Functional disorder;Future;Gall Bladder Diseases;gastrointestinal;Genetic;genetic predictors;Genetic study;Genitourinary system;Goals;grasp;Health Services Accessibility;Hypotension;Infrastructure;International;Interruption;Interview;Intestines;Length;Long-Term Effects;longitudinal database;longitudinal dataset;Longitudinal Studies;Medical Records;member;men;Methods;Muscular Dystrophies;Myotonia;Myotonic Dystrophy;Myotonic dystrophy type 1;Myotonic dystrophy type 2;Neoplasms;neuromuscular;novel;Outcome Measure;outreach;patient engagement;patient population;Patient Recruitments;patient registry;Patient Representative;Patient Self-Report;Patients;Pharmaceutical Preparations;Population Heterogeneity;post-market;Quality of life;Questionnaires;rapid growth;Recommendation;recruit;Registries;remote assessment;Reporting;Reproductive Health;Research;Research Personnel;Resource Sharing;Resources;Running;skeletal muscle weakness;Smooth Muscle;Source;Spanish;surveillance study;Surveys;Symptoms;synergism;System;therapeutic target;Translating;transmission process;Underrepresented Minority;Vision;volunteer;Woman;Women's Health

PROJECT_TITLE: Scientific Resource Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Orphan Drug;Rare Diseases

PI_NAMEs: WANG, ERIC T (contact)

PROJECT_TERMS: Address;Architecture;Atrophic;Awareness;Biological;Biological Assay;Biological Markers;Biology;Biotechnology;career;Cell Compartmentation;cell type;Cells;Clinic;Clinical;clinical development;Clinical Investigator;Clinical Research;Clinical Trials;Communication;community building;Competence;Computer Analysis;computing resources;Country;Critical Thinking;Curiosities;Data;deep sequencing;Disease;DNA analysis;drug development;Dryness;Educational process of instructing;Employment Opportunities;Ensure;Environment;Exercise;Explosion;Exposure to;Family;Feedback;Foundations;Future;Gene Expression;gene therapy;genome sequencing;graduate student;Heterogeneity;High-Throughput Nucleotide Sequencing;Human;Image;Image Analysis;imaging modality;Immunoglobulin Fragments;improved;Individual;Industry;Infrastructure;innovation;Institution;interest;Investments;Knowledge;Laboratories;Language;Maps;Medical Students;member;Modality;Molecular;Mus;Muscle Cells;Muscle Fibers;Muscular Atrophy;Muscular Dystrophies;Myotonic Dystrophy;Natural regeneration;Nature;neuromuscular;next generation;Oligonucleotides;Optics;Pathogenesis;patient population;Patients;Peptide Fragments;Pharmacodynamics;Phenotype;Postdoctoral Fellow;pre-clinical;Pre-Clinical Model;preclinical development;programs;protein biomarkers;Proteins;Proteomics;Qualifying;recruit;Reproducibility;Research;research and development;Research Personnel;Resources;restoration;RNA;Role;Sampling;Science;Scientist;Side;Site;skills;small molecule;Solid;Symptoms;targeted treatment;Techniques;Technology;Therapeutic;Time;Tissues;tool;Training;Training and Education;training opportunity;transcriptome sequencing;transcriptomic profiling;transcriptomics;Translating;Visit;whole genome

PROJECT_TITLE: Training and Educational Core


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Rare Diseases

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;ACTA1 gene;Address;Adult;Affect;Alternative Splicing;Animal Model;Area;Bacterial Artificial Chromosomes;Binding;Biochemical;Blood;Breeding;Cells;cerebral atrophy;circadian;Clinical;Clinical Trials;design;Development;Disease;Exons;feasibility testing;Foundations;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Genomics;Germ Lines;Health;heart defect;Histologic;Human;improved;in vivo;in vivo evaluation;Inherited;Injections;Introns;Late-Onset Disorder;Length;Life;life span;Location;Microsatellite Repeats;Modeling;Molecular;mouse genome;mouse model;Mus;Muscle;Muscle Weakness;Muscular Dystrophies;mutant;Mutation;Myocardium;Myopathy;Myotonia;Myotonic dystrophy type 1;New Agents;Nuclear RNA;Nucleotides;Outcome;Pathogenesis;Pathogenicity;Patients;Penetration;Phenotype;Physiological;Proteins;Reporting;Research;Research Priority;Resources;RNA;RNA Processing;RNA Splicing;RNA-Binding Proteins;Short Tandem Repeat;Site;skeletal;Skeletal Muscle;Sleep;spatiotemporal;Study models;Testing;Therapeutic;therapeutic development;therapeutic evaluation;therapeutic target;therapeutically effective;Tissues;tool;Transcript;Transgenic Mice;Transgenic Model;Transgenic Organisms;Translations;Untranslated RNA

PROJECT_TITLE: DM2 pathomechansims and therapeutic development


NIH_SPENDING_CATS: Biotechnology;Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Rare Diseases

PROJECT_TERMS: Address;Affect;Alleles;Animal Model;Antisense Oligonucleotides;Biological Assay;Cell Nucleus;Clinical;Clinical Trials;cofactor;Confounding Factors (Epidemiology);CUG repeat;Cytoplasm;Defect;Degradation Pathway;Disease;DNA Methylation;early phase trial;Future;Gene Expression;Genes;Genetic Transcription;Heterozygote;Human;human disease;knock-down;Knock-in;Label;Length;Life Cycle Stages;Measurement;Measures;Messenger RNA;Metabolic;Metabolism;MicroRNAs;Modeling;mouse model;mRNA Precursor;mRNA Transcript Degradation;Mus;Muscle;Muscular Dystrophies;mutant;Myoblasts;Myocardium;Myopathy;Myotonia;Myotonic dystrophy type 1;Nonsense-Mediated Decay;Nuclear;Nuclear Export;Nuclear Protein;Oligonucleotides;Pathway interactions;Pharmaceutical Preparations;phosphoramidite;Play;Production;Proteins;ran GTP-Binding Protein;relative effectiveness;Reporting;Research;Ribonuclease H;ribosome profiling;Risk;RNA;RNA Splicing;Role;Single Nucleotide Polymorphism;Skeletal Muscle;Small Interfering RNA;Smooth Muscle;spatiotemporal;Testing;Therapeutic;Transcript;Transcription Initiation;transcriptome;Translations;Western Blotting

PROJECT_TITLE: Mechanisms underlying differential efficacy of DM1 therapeutics


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Human Genome;Huntington's Disease;Muscular Dystrophy;Myotonic Dystrophy;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

PROJECT_TERMS: Address;Adult;Affect;Age;age effect;age related;Alleles;Anti-sense RNA;Binding Proteins;Biological;Biological Assay;Blood specimen;Clinical;Clinical assessments;Clinical Research;Clinical Trials;cohort;Communities;Complex;cost;cost effective;CUG repeat;Defect;deltoid muscle;Development;Devices;DNA;DNA Library;Electrocardiogram;Exons;Family;Future;Genetic;genetic analysis;Genetic Counseling;Genetic Determinism;Genetic Diseases;genetic variant;genome wide association study;genome-wide;genome-wide analysis;genotyped patients;Growth;Hand Strength;Home;Huntington Disease;improved;in utero;Individual;Inherited;Interruption;Interview;Introns;Length;Leukocytes;Link;Maps;Medicine;Mendelian disorder;Messenger RNA;Methods;Mismatch Repair;Molecular;Muscle;muscle strength;Muscular Dystrophies;Myotonic Dystrophy;Myotonic dystrophy type 1;Myotonic dystrophy type 2;Nature;new therapeutic target;novel;Nuclear;Nuclear RNA;Pathogenesis;patient engagement;patient variability;Patients;Peptides;peripheral blood;Persons;Phase;Phenotype;Physical condensation;Play;polyglutamine;Predictive Value;Pregnancy;Process;Productivity;progenitor;Proteins;recruit;remote assessment;Reporting;Research;Residual state;Respiratory physiology;RNA;RNA Splicing;Role;Severities;Severity of illness;sex;Skeletal Muscle;Somatic Cell;Statistical Models;stem;Stratification;Telephone;Testing;Therapeutic;therapeutic development;therapeutic target;therapeutically effective;tibialis anterior muscle;Time;Tissues;Toxic effect;trait;Transcriptional Regulation;Translations;Variant;Videoconferencing;Visit

PROJECT_TITLE: Biological determinants of myotonic dystrophy variability


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences

ORG_CITY: WINSTON-SALEM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative In this supplement, we take advantage of a novel transgenic mouse model (eEF2K cKI) to investigate the effects of neuronal eEF2K overexpression on synaptic and cognitive function. Findings from the project will help understand the roles of protein synthesis dysregulation in Down syndrome-associated cognitive impairments.

PI_NAMEs: MA, TAO  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Aging;aging related;Brain;brain tissue;Cognitive deficits;cognitive function;Defect;Dendritic Spines;Down's Syndrome;Exhibits;Functional disorder;Funding;Grant;Hippocampus;Impaired cognition;Impairment;improved;Long-Term Potentiation;Molecular;Morphology;mouse model;Mus;Neurons;novel;overexpression;Patients;Phosphorylation;postsynaptic;Protein Biosynthesis;protein profiling;Role;Synapses;synaptic failure;synaptic function;Synaptic plasticity;Testing;Transgenic Mice;Up-Regulation

PROJECT_TITLE: Targeting protein synthesis dysregulation in Down syndrome-associated cognitive impairments with aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Latinas suffer disproportionately from breast cancer, relative to non-Latina Whites, including late-stage diagnoses and worse mental health during diagnostic evaluation, treatment, and survivorship. This Diversity Supplement aims to extend the Parent Grant (R01CA261638), by providing insight into factors that contribute to Latinas' decisions to seek and provide social support after receiving abnormal mammogram results through a prospective qualitative study. Further, the Diversity Supplement will train a bicultural, bilingual Latina trainee seeking a Master's of Social Work degree in health communications and qualitative research methods, which will enhance the diversity and research impact of the nation's workforce of emerging clinician scientists.

PI_NAMEs: MOLINA, YAMILE  (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: bilingualism;Breast Cancer Detection;career development;Caring;Clinical;clinical training;Communities;community engaged research;community engagement;Community Networks;Development;Diagnosis;diagnosis quality;Diagnostic;Disclosure;Disparity;Distress;Educational workshop;empowerment;Environment;Equity;Evaluation;experience;Family;Family member;follow-up;Goals;graduate school;Grant;Guidelines;health communication;insight;Institution;Intervention;Knowledge;Latina;Latina Population;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Manuscripts;marginalized community;Mental Health;Mentorship;Outcome;parent grant;parent project;Parents;Preparation;Process;prospective;psychosocial;Qualitative Methods;Qualitative Research;Quality of life;Research;Research Methodology;Research Personnel;Research Training;Resolution;Scientist;screening;skills;social disparities;Social isolation;Social Network;social stigma;Social support;Social Work;Structure;survivorship;symposium;Training;Well in self;Work

PROJECT_TITLE: Empowering Latinas to Obtain Guideline-Concordant Breast Cancer Screenings


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Immunotherapy;Orphan Drug;Prevention;Prostate Cancer;Rare Diseases;Urologic Diseases;Women's Health Research

ORG_NAME: DANA-FARBER CANCER INST

PHR: Overall Project Narrative The primary goal of the Cancer Center is to promote collaborative interactions across seven consortium institutions that will lead to new approaches to cancer prevention, diagnosis, and treatment. These advances will occur while also advancing the Center’s mission to reduce disparities and to train future leaders in cancer research.

PI_NAMEs: EBERT, BENJAMIN LEVINE (contact)

PROGRAM_OFFICER_NAME: PTAK, KRZYSZTOF

PROJECT_TERMS: Acceleration;Advanced Malignant Neoplasm;anti-cancer research;Appointment;Awareness;base;Basic Science;Behavioral;bench-to-bedside translation;Biological;Biology;Boston;Cancer Biology;cancer care;cancer cell;Cancer Center;cancer epidemiology;Cancer Etiology;cancer genetics;cancer health disparity;Cancer health equity;cancer immunotherapy;Cancer Patient;cancer prevention;cancer risk;care delivery;Catchment Area;Cell Therapy;Clinic;Clinical;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engagement;Comprehensive Cancer Center;convict;Dana-Farber Cancer Institute;Data Science;Development;Developmental Therapeutics Program;Diagnosis;disparity reduction;Dreams;Early Diagnosis;Education;Educational Activities;empowerment;Ensure;Environment;Equity;Faculty;first-in-human;Fostering;Funding;Future;Future Generations;General Hospitals;Genetic;Genetic Heterogeneity;Goals;Grant;Grooming;Health Sciences;high risk population;Hospitals;immune checkpoint blockade;improved;improved outcome;Individual;Inequity;Infrastructure;innovation;insight;Institution;inter-institutional;interdisciplinary approach;interdisciplinary collaboration;Investigation;Israel;Laboratories;Laboratory Finding;Leadership;Learning;leukemia;Lymphoma;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Massachusetts;Medical center;medical schools;Melanoma;member;Mentorship;Minority;Mission;Modeling;Molecular;Multiple Myeloma;neuro-oncology;new technology;novel;novel strategies;novel therapeutics;Oncogenic;operation;Outcome;Pathogenesis;Pathway interactions;patient population;Pediatric Hospitals;Phase;Phase III Clinical Trials;Population;Population Sciences;prevent;Prevention;Prevention strategy;Preventive;Primary Neoplasm;programs;Public Health Schools;Renal Carcinoma;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Risk Assessment;Risk Reduction;Schools;Science;Screening for cancer;Services;Societies;Specimen;Strategic Planning;Structure;synergism;Talents;therapy resistant;Training;Training and Education;Transcend;Translational Research;Treatment outcome;treatment strategy;tumor immunology;Underserved Population;Universities;Woman;Work

PROJECT_TITLE: Dana-Farber/Harvard Cancer Center

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Prevention;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE The Lineberger Comprehensive Cancer Center (LCCC) forms the nexus for researchers focused on understanding and identifying the mechanisms leading to, the prevention of, and treatments for cancer. LCCC is an integral component of the research mission at The University of North Carolina (UNC) at Chapel Hill, coalescing the cancer research capabilities of the Schools of Medicine, Public Health, Pharmacy, and Nursing, and the College of Arts and Sciences. The LCCC strives to reduce cancer incidence, morbidity, and mortality in North Carolina, the United States and across the globe through innovative research, cutting-edge treatments, multi-disciplinary training, education and outreach.

PI_NAMEs: EARP, H. SHELTON (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: anti-cancer research;Appointment;Arts;authority;Award;Basic Cancer Research;Basic Science;Behavioral;Bioinformatics;Biology;Budgets;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer epidemiology;cancer genetics;cancer research center director;cancer therapy;career;Caregivers;Caring;Catchment Area;Chemicals;chimeric antigen receptor T cells;Clinic;Clinical Data;Clinical Protocols;Clinical Research;Clinical Sciences;Clinical Trials;college;Communication;Communities;community based participatory research;community college;community engagement;Community Outreach;Comprehensive Cancer Center;Consultations;Data;data management;Development;Direct Costs;Discipline of Nursing;Disease;Disparity;drug discovery;Early Diagnosis;Education and Outreach;Epidemiology;epidemiology study;Epigenetic Process;Evaluation Research;Facility Construction;Faculty;Fostering;Funding;Future;Genetic Research;Genomic approach;Government;Grant;Health;Health Resources;Health Services;Healthcare;Human;imaging detection;Incidence;Information Systems;Infrastructure;innovation;Institution;Insurance Carriers;Intervention;Intervention Trial;Investments;Leadership;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Medicaid;medical schools;Medicare;member;minority disparity;Minority Groups;Mission;Molecular Epidemiology;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Names;neoplasm registry;North Carolina;Oncology;operation;Outcome;outreach;Patient Care;Patients;Performance;Pharmacologic Substance;Pharmacy facility;Policies;Population;population based;population health;Population Heterogeneity;Population Sciences;Prevention;Privatization;Productivity;programs;Protocols documentation;Public Health;public policy on tobacco;Publications;Publishing;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Rural Population;safety net;Schools;Science;Scientist;screening services;senior faculty;Services;Stretching;survivorship;System;Talents;Technology;The Cancer Genome Atlas;Therapeutic;Training;Training and Education;Translating;Translations;undergraduate student;United States;Universities;Urban Population

PROJECT_TITLE: Cancer Center Support Grant


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

PHR: PUBLIC HEALTH RELEVANCE STATEMENT – Abramson Cancer Center Cancer is the second leading cause of death in the United States and prevalent in the ethnically diverse catchment area of the Abramson Cancer Center (ACC), which consists of 12 contiguous counties in Pennsylvania, New Jersey, and Delaware, in which 81.4% of ACC's patients reside. Through our Research Programs and Community Outreach and Engagement, the ACC addresses the burden imposed by highly prevalent cancers in the catchment area, including breast, prostate, lung, colorectal, melanoma, and lymphoma. ACC basic, clinical, and population science research – along with Community Outreach and Engagement Activities – are integrated to prevent, diagnose, and treat these cancers and address cancer risk factors to promote healthy living.

PI_NAMEs: VONDERHEIDE, ROBERT H (contact)

PROJECT_TERMS: Abbreviations;Abramson Cancer Center at the University of Pennsylvania;acronyms;Address;Adult;anti-cancer research;Area;Automobile Driving;Basic Science;behavioral economics;Beverages;biobank;biomedical informatics;Black race;Brain Neoplasms;brca gene;Breast;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer immunotherapy;Cancer Patient;cancer risk;cancer surgery;Capital;Caring;Catchment Area;Cause of Death;Cells;Cellular biology;Child;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Data;clinical investigation;Clinical Investigator;clinical practice;Clinical Protocols;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Colorectal;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;Country;County;data management;Delaware;Development;Diagnosis;Disease;DNA Damage;Early Diagnosis;Ecosystem;Electronic Health Record;Enrollment;environmental carcinogenesis;environmental toxicology;Epigenetic Process;ethnic diversity;Ethnic Origin;Face;Fostering;Funding;gene therapy;Genetic;Geography;Germ Lines;Health behavior;health care delivery;Health Policy;Health Services Research;Hospitals;Human Papilloma Virus Vaccination;imaging program;Immunology;Immunotherapy;improved;Incidence;innovation;Institution;Intervention Trial;Journals;Laboratories;Leadership;Lung;Lymphoma;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuscripts;medical schools;Medically Underserved Area;Medicine;Melanoma;member;microbiome;Mission;Modernization;molecular imaging;Monitor;Nature;New Jersey;novel strategies;novel therapeutic intervention;Oncogenes;outreach;Paper;patient oriented;Patients;Pediatric Hospitals;Pediatric Oncology Group;Pennsylvania;personalized diagnostics;Philadelphia;Population;population based;Population Research;Population Sciences;prevent;Prevention;Productivity;programs;Prostate;Protocols documentation;Proton Radiation;proton therapy;public health relevance;Publications;Publishing;Radiobiology;radiomics;Recording of previous events;Research;Research Personnel;Resource Sharing;Resources;response;Rest;Risk;Risk Assessment;Risk Factors;Science;Scientist;Services;severe mental illness;Smoking;smoking cessation;survivorship;System;T-Lymphocyte;targeted treatment;tobacco carcinogenesis;tobacco control;Training and Education;Translating;translational medicine;Translational Research;translational scientist;translational therapeutics;Translations;treatment trial;tumor metabolism;tumor microenvironment;Tumor Tissue;Underrepresented Populations;United States;United States National Institutes of Health;Universities;University Hospitals;Vision

PROJECT_TITLE: Abramson Cancer Center Support Grant


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Ovarian Cancer;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_DEPT: PHARMACOLOGY

PHR: Ovarian cancer is the most lethal gynecological malignancy, and the process of ovulation is a risk factor. Our team developed novel microfluidic systems that allow for 3D culture of the ovary and the fallopian tube, which recreate ovulation ex vivo. Building on these systems, we will investigate factors from ovulation that drive tumor initiation, expansion of a secretory and stem cell niche, as well as ovarian specific tumor cell migration using fallopian tube models.

PI_NAMEs: BURDETTE, JOANNA E (contact);COPPETA, JONATHAN

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;3D Print;Adhesions;Agar;Age;Anatomy;Biological;Biological Models;bioprinting;blocking factor;Body System;Breast Feeding;cancer diagnosis;Cancer Etiology;cancer stem cell;carcinogenesis;Carcinoma;CD44 gene;Cell Line;Cells;Cessation of life;Clinical;Collaborations;Copy Number Polymorphism;corpus luteum;Data;Detection;Development;Devices;Disease;DNA Damage;Engineering;Epithelial Cells;Epithelium;Exposure to;Fallopian Tube Neoplasms;female reproductive system;female reproductive tract;fimbria;Grant;high risk;Hormones;Human;human tissue;IGF2 gene;improved;in vivo;induced pluripotent stem cell;inhibitor;innovation;Invaded;Lactation;Lesion;LGR5 gene;Location;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of fallopian tube;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Measures;Menarche;Menstrual cycle;Metastatic Malignant Neoplasm to the Ovary;Microfluidics;migration;Modeling;Monitor;Mus;Names;Neoplasm Metastasis;neoplastic;neoplastic cell;novel;Oral Contraceptives;organ on a chip;Organoids;Ovarian;Ovary;Ovulation;p53-binding protein 1;Paper;Pathway interactions;Penetration;Predictive Factor;Pregnancy;prevent;Prevention;Prevention strategy;Process;Proliferating;Protein Secretion;Proteins;Proteomics;PTEN gene;Publishing;replication stress;Repression;reproductive;Research Support;response;Risk Factors;Risk Reduction;Role;Secretory Cell;Serous;Signal Transduction;Site;small molecule;Source;spheroids;stem cell biomarkers;stem cell niche;stem cell population;stemness;Stromal Cells;Structure;Surface;Survival Rate;System;Technology;Testing;three dimensional cell culture;Time;Tissues;transcriptomics;treatment strategy;tumor;Tumor Cell Migration;tumor initiation;Tumor Suppressor Proteins;tumorigenic;versican;WNT4 gene;Women's mortality;Xenograft procedure

PROJECT_TITLE: Dynamic Interactions of the Ovarian-Fallopian Axis in High Grade Serous Ovarian Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (80)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Genetics;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project narrative. The intent of this proposal is to provide the baccalaureate candidate with the assets needed to render her highly competitive for a career in academic medicine. With this in mind, we have proposed, 1) a study of the function of ZNF671, a gene frequently methylated in breast cancer, that will provide a solid training in laboratory investigation, 2) courses that will bolster her current understanding of cancer and treatment strategies, and, 3) assistance in career development through conferences, mentorship, communication and networking. This three- pronged approach will provide the candidate with the all the tools necessary for success.

PI_NAMEs: SUKUMAR, SARASWATI  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Biological;Biological Markers;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Detection;breast lesion;cancer cell;cancer type;Carcinoma;career;career development;Communication;Cultured Cells;Data;Data Analyses;Detection;detection assay;Development;Disease;DNA Methylation;Doctor of Philosophy;Embryo;Epigenetic Process;epigenetic silencing;Fine needle aspiration biopsy;Gene Expression;gene panel;Genes;Goals;In Vitro;in vivo;industry partner;Investigation;knock-down;Knock-out;Laboratories;Learning;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Medicine;Mentorship;Methods;Methylation;Microarray Analysis;Modeling;Molecular;morphogens;neoplastic;Normal tissue morphology;overexpression;parent grant;Pathway interactions;peer coaching;Phenotype;Prediction of Response to Therapy;Process;prognostication;programs;Property;Proteins;Reporting;Solid;stem cell population;stemness;success;symposium;Techniques;Testing;tool;Training;Training Programs;treatment strategy;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;Validation;Work;zinc finger nuclease;Zinc Fingers

PROJECT_TITLE: DEVELOPMENT OF AN AUTOMATED CARTRIDGE-BASED BREAST CANCER DETECTION ASSAY- AN ACADEMIC-INDUSTRIAL PARTNERSHIP

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(57)-R]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

PI_NAMEs: GUPTA, GAORAV P. (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Acceleration;Alleles;Apical;ATM Signaling Pathway;Breast;Breast Cancer Model;Breast Epithelial Cells;breast tumorigenesis;c-myc Genes;Cancer Etiology;cancer initiation;cancer prevention;cancer therapy;Cell Cycle;Cell Cycle Checkpoint;Cell Cycle Progression;Cell Cycle Stage;Cells;chemotherapy;Chromosomal Instability;Chromosome abnormality;Cicatrix;clinically relevant;Complex;Data;Data Set;Development;Distant Metastasis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA-dependent protein kinase;Engineering;ERBB2 gene;Estrogens;Gene Expression;Gene Mutation;Genetic Transcription;genome sequencing;genomic aberrations;Genomic Instability;Genomics;Goals;Heterogeneity;Human;in vitro testing;inhibitor;insight;Malignant Breast Neoplasm;Measures;Mediating;Microscopy;Modeling;Molecular Profiling;mouse model;Mus;Mutate;Mutation;Neoplasms;neoplastic;novel strategies;Oncogene Activation;Oncogenes;overexpression;Pathogenesis;Pathway interactions;Pattern;Penetrance;pharmacologic;Phenotype;Predisposition;prevent;progesterone receptor negative;programs;Proliferating;prospective;replication stress;Reporter;Reporting;Resolution;response;Role;sensor;single-cell RNA sequencing;Testing;Therapeutic;Time;TP53 gene;Transgenic Organisms;Transplantation;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Promotion;Tumor Suppression;tumorigenesis;tumorigenic;whole genome

PROJECT_TITLE: Mre11-Dependent DNA Damage Responses in Breast Cancer Pathogenesis

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE  Cancer immunotherapies have achieved impressive clinical outcomes in a small subset of cancer patients. We will develop a novel therapeutic agent that can boost cancer immunotherapies. We expect that successful completion of this project will make a significant impact on cancer treatments.

PI_NAMEs: WANG, JIN  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Advanced Malignant Neoplasm;Affinity;Affinity Chromatography;Amines;Amino Acids;amino group;analog;anti-PD-1;Antibody-drug conjugates;Area;Binding;Binding Sites;Biological Assay;Biology;biomarker identification;BODIPY;C-terminal;cancer cell;Cancer cell line;cancer immunotherapy;Cancer Patient;cancer therapy;Carbon;Carboxylic Acids;Cell Survival;Cells;Chelating Agents;Chemicals;Chemistry;Chimeric Proteins;Clinical;clinical translation;Code;Competitive Binding;Complex;congenital immunodeficiency;Cysteine;design;detector;Development;Digit structure;Docking;Dyes;Engineering;Ensure;Environment;enzyme activity;Escherichia coli;Ethacrynic Acid;Exclusion;experimental study;Fluorescence;Fluorescence Polarization;Fluorescence Resonance Energy Transfer;Fluorescent Dyes;Fluorides;Future;Glutamic Acid;Glutathione;Glutathione S-Transferase;Glutathione Transferase Inhibitor;Glycine;gut inflammation;Human;Hydrogen Bonding;Hydrolysis;Hydrophobicity;Imidazole;Immobilization;Immune system;Immunocompetent;Immunophenotyping;improved;Incubated;Individual;Induction of Apoptosis;Inflammatory;inhibitor;innate immune pathways;Interferons;Intervention;Kinetics;Knock-out;Label;Length;Ligands;loss of function;Lysine;Measurement;Measures;Melanoma;meter;Methionine;Methodology;Methods;Modeling;Modification;Molecular;Mus;Mutation;N-terminal;Nitrilotriacetic Acid;novel strategies;novel therapeutics;Oral;Outcome;Pathway interactions;patient response;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphotransferases;Pre-Clinical Model;Predisposition;Process;Protac;Protein Kinase Interaction;protein purification;Proteins;Proteomics;Protocols documentation;Reaction;reaction rate;Receptor-Interacting Protein;Recombinants;recruit;Reduced Glutathione;Reporting;response;Running;Scaffolding Protein;Schistosoma japonicum;Signal Transduction;Site;Solvents;Specificity;Structure;success;Sulfonamides;Symptoms;synergism;System;Technology;Testing;TEV protease;Therapeutic Agents;thioether;Time;Titrations;TNF gene;tobacco etch virus;Toll-like receptors;Tracer;tumor;tumor initiation;tumor microenvironment;Weight;Work

PROJECT_TITLE: Development of First-in-Class RIPK1 Degraders to Improve Cancer Immunotherapies


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE [parent project] State of the art methods for the early detection and monitoring of cancer are either invasive, time-consuming, expensive, or frequently inaccurate, which hinders the routine screening of at risk-patients to improve survival rates. Here, we propose a portable neural network enabled spectroscopy platform to diagnose cancer in patient biofluids (saliva, blood plasma, and sweat). The expected outcome is to deliver a novel point of care liquid biopsy platform to better classify, monitor, and improve diagnostic sensitivity of a broad range of diseases and conditions, with focus on early/late-stage head and neck cancer.

PI_NAMEs: CARNEY, RANDY ;GOMEZ DIAZ, JUAN SEBASTIAN  (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: absorption;accurate diagnostics;Address;Algorithms;Benign;Biological Markers;Biopsy;Biosensor;Blinded;Blood;Calibration;Cancer Control;Cancer Detection;cancer diagnosis;cancer type;circulating biomarkers;Classification;Clinical;clinical diagnosis;cohort;Complex;Computer software;Consumption;Data;data streams;deep neural network;design;Detection;detection limit;detector;Devices;Diabetes Mellitus;Diagnosis;Diagnostic;Diagnostic Sensitivity;Disease;Dryness;Early Diagnosis;Economics;effective therapy;Electromagnetics;Elements;Fingerprint;Foundations;Fourier Transform;Fourier transform infrared spectrometry;Future;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;Head and Neck Surgery;Health Status;Heart Diseases;Heterogeneity;high reward;high risk;Histopathology;Image;imaging modality;Immunohistochemistry;improved;improved outcome;Individual;infrared spectroscopy;innovation;interdisciplinary approach;Interferometry;Label;learning network;Libraries;Light;liquid biopsy;Liquid substance;Machine Learning;machine learning algorithm;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Metabolic;Metabolic Diseases;metabolomics;Methods;miniaturize;Modeling;Monitor;Monitoring for Recurrence;multidisciplinary;multiplex detection;nano;nanopattern;nanoscale;Neck Cancer;neural network;neural network architecture;Neural Network Simulation;novel;Otolaryngology;Outcome;Output;parent project;Pathology;patient stratification;Patients;Performance;Plasma;plasmonics;point of care;portability;Process;Raman Spectrum Analysis;Rapid diagnostics;rapid testing;Recurrence;Risk;routine screening;Saliva;Sampling;segregation;sensor;Signal Transduction;smartphone application;Solid;Specificity;Spectroscopy, Fourier Transform Infrared;Spectrum Analysis;Spottings;Staging;Statistical Data Interpretation;Survival Rate;System;Techniques;Technology;Testing;Time;tool;Translating;Update;voltage;wearable device;Width;Work

PROJECT_TITLE: Merging Nanoscale IR Spectroscopy and Neural Networks for Cancer Detection

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: The prevalence of cardiometabolic risk factors (e.g., obesity) among youth remains high globally, and gestational and childhood exposure to PFAS may adversely influence cardiometabolic risk. However, the biological mechanisms underlying these associations are not well-understood, but PFAS may accelerate biological aging; thus, we propose using epigenetic clocks, a method to measure biological age, to understand the link between PFAS exposure and cardiometabolic health. These results will help to identify PFAS-associated biological targets during early-life with the goal of preventing later-life risk of cardiometabolic disease in historically exposed populations.

PI_NAMEs: BRAUN, JOSEPH M (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: 12 year old;accelerated epigenetic aging;Adolescence;Adolescent;Affect;Age;age acceleration;aging biomarker;Biological;biological age;Biological Aging;Biological Markers;Biological Process;biomarker identification;Biostatistical Methods;Birth;Blood;Blood Pressure;blood pressure elevation;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Chemicals;Child;Child Development;Child Health;Childhood;Cholesterol;consumer product;critical period;Data;Data Analyses;data integration;Development;Diet;Disease;disorder risk;DNA Methylation;DNA Sequence Alteration;doctoral student;drinking water;Dust;early adolescence;Early identification;Environment;environmental chemical;Environmental Epidemiology;Environmental Pollutants;Epidemiologic Methods;epidemiology study;Epigenetic age;epigenetic aging;epigenetic clock;epigenetic marker;Epigenetic Process;Exposure to;Fetal Development;Food;Food Packaging;Future;Gene Expression;Genes;Gestational Age;Glucose;Goals;graduate student;Health;health data;high dimensionality;Homeostasis;Human;Human Milk;Hypermethylation;in utero;Individual;indoor pollutant;Industrial Product;Infant;Ingestion;insight;Insulin;Joints;Knowledge;late life;Learning;Leukocytes;Life;life span;Link;Lipids;Measures;Mediating;metabolomics;Methodology;Methods;multidimensional data;novel;Obesity;Ohio;Outcome;parent grant;Pathway interactions;Peripheral;Phenotype;phthalates;placental transfer;Poly-fluoroalkyl substances;Population;Pregnancy;Pregnant Women;Prevalence;prevent;Prospective cohort;Publishing;rate of aging;Reporting;Research;Research Personnel;Risk;Risk Factors;Risk Marker;Role;Serum;Smoking;Surrogate Mothers;Testing;tool;Toxic effect;Training;Work;Youth

PROJECT_TITLE: Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic Health


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Digestive Diseases;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Social Determinants of Health;Substance Misuse;Tobacco

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Substance use and associated HIV, hepatitis C (HCV), and mental health comorbidities continue to drive morbidity and mortality globally. Interdisciplinary, interinstitutional collaborations can challenge paradigms to achieve cross-cutting advances in substance use treatment that limit the spread of HIV/HCV and decrease morbidity and death. As this training program is located in states with high rates of substance use, we propose an interdisciplinary faculty career development program to increase the number of well-prepared investigators with expertise in the risk factors for, and mechanisms underlying, substance use and the behavioral, environmental, and health disparity aspects of substance use and its associated morbidity and mortality.

PI_NAMEs: FREIBERG, MATTHEW S;KORTHUIS, PHILIP TODD;TINDLE, HILARY A. (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;addiction;alcohol misuse;alcohol research;Behavioral;career;career development;Cessation of life;Clinical Treatment;Clinical Trials Network;cohesion;cohort;Collaborations;comorbidity;Data;didactic education;Disease;Doctor of Philosophy;Drug abuse;Drug usage;Educational Curriculum;Environment;Faculty;faculty mentor;Fellowship Program;Fostering;hands on instruction;Health;health disparity;Health Sciences;Hepatitis C;HIV;HIV Infections;HIV/HCV;improved;Infrastructure;innovation;Institution;inter-institutional;K-Series Research Career Programs;Laboratories;Life Style;Location;Mental Health;Mentored Clinical Scientist Development Program;Mentors;Morbidity - disease rate;mortality;next generation;Nicotine Dependence;Opioid;Oregon;Persons;Program Development;programs;Recording of previous events;Research;Research Personnel;Research Project Grants;Research Training;Risk Factors;Rural;Science;Scientist;Site;Structure;substance use;substance use treatment;Tennessee;Time;Tobacco Dependence;Training;Universities;Vulnerable Populations

PROJECT_TITLE: Vanderbilt Oregon COllaborative Scholar Training in Addiction Research (COSTAR)

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: The persistently critically ill—while not common—are costly, growing in incidence, and their survivorship is associated with high morbidity. Survivorship for Veterans with persistent critical illness has largely been understudied because of the mistaken assumption that all these Veterans will die within the year. This study will help us understand why some VHA hospitals have better long-term quality of life outcomes following a hospitalization with persistent critical illness. By identifying strategies used by high-performing VHA hospitals, we will be able to identify, share, and create a best practices toolkit to improve Veteran survivorship and recovery from a hospitalization with persistent critical illness.

PI_NAMEs: VIGLIANTI, ELIZABETH MARIE (contact)

PROJECT_TERMS: Administrator;Adopted;Adult;Bed Occupancy;Caregivers;Caring;causal model;Characteristics;Chronic Disease;Clinical Research;cohort;Collection;Complex;cost;Critical Care;Critical Illness;Data;design;Development;Discipline of Nursing;effectiveness/implementation trial;electronic health record system;epidemiology study;Etiology;experience;follow-up;Future;Goals;Hospital Administration;hospital care;Hospitalization;Hospitals;Impaired cognition;implementation framework;implementation science;improved;Incidence;innovation;Inpatients;Institution;Intensive Care Units;interest;Interview;Leadership;Left;Methodology;Methods;Morbidity - disease rate;mortality;multidisciplinary;Outcome;Outpatients;Palliative Care;Patients;physical impairment;Policies;Process;prospective;Qualitative Research;Quality of life;Recommendation;Recovery;Research;Research Priority;Resources;Risk;risk stratification;Sampling;Structure;success;Surveys;Survivors;survivorship;Telephone;Testing;Translating;United States Health Resources Administration;Variant;Veterans;Veterans Health Administration;virtual;Visit;whole health;Work

PROJECT_TITLE: IMPROving care for VEterans with Persistent Critical Illness (IMPROVE PerCI)

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Narrative Reading deficits contribute significantly to poor functional outcome in schizophrenia. The parent grant for this supplement evaluates neural mechanisms underlying reading impairment in schizophrenia. This supplement evaluates the potential benefits of visually targeted cognitive remediation.

PI_NAMEs: JAVITT, DANIEL C. (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Auditory;auditory processing;Auditory system;Clinic;Cognition;Cognitive remediation;Computer Models;Contrast Sensitivity;Data;effectiveness evaluation;Event-Related Potentials;Eye Movements;first episode schizophrenia;Functional disorder;Functional Magnetic Resonance Imaging;functional outcomes;Funding;Future;Generations;Impairment;indexing;Individual;lexical;Measures;Modeling;motion sensitivity;Multimodal Imaging;neuromechanism;oculomotor;online intervention;Outcome;parent grant;Participant;Performance;Population;Process;programs;Randomized Controlled Clinical Trials;Reader;Reading;reading ability;reading difficulties;remediation;sample fixation;Schizophrenia;Sensory;sensory integration;skills;Visual;visual tracking

PROJECT_TITLE: Neural Mechanisms of Reading Dysfunction in Schizophrenia


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE This proposal leverages the Drosophila model system to address the neural mechanisms underlying social interactions, from processing of cues emitted by a communication partner to generating complex behaviors in response to those cues. Impairments in processing sensory information or generating motor behaviors, particularly in the context of social interactions, underlie several human disorders including Parkinson’s disease and Autism spectrum disorder. This proposal will uncover general principles of neural circuit function that will inform studies of sensorimotor integration in more complex systems.

PI_NAMEs: MURTHY, MALA  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TITLE: Uncovering the Neural Mechanisms that Flexibly Link Sensory Processing to Behavior


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This study will determine how the immune cells of the brain, known as microglia, function during brain development. We will test the hypothesis that immune signals involved in antiviral defenses can serve a dual role in the developing brain by eliminating some types of nerve cells, particularly during stress. This novel mechanism could help explain how immune challenges during early development can impact brain function throughout life.

PI_NAMEs: MOLOFSKY, ANNA V (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Acceleration;Adolescent;Aging;Animals;autism spectrum disorder;Behavior;Brain;brain cell;Brain Injuries;brain parenchyma;Cells;cellular targeting;Coculture Techniques;Communication;Cues;cytokine;Data;density;deprivation;Development;DNA Double Strand Break;Double-Stranded RNA;ds-DNA;Eating;Electrophysiology (science);excitatory neuron;experimental study;Extracellular Matrix;follow-up;Future;gain of function;Goals;hippocampal pyramidal neuron;Image;Immune;Immune signaling;Immune system;Immunohistochemistry;In Situ;In Vitro;in vivo;innate immune pathways;Interferon alpha;Interferon Type I;Interferon-beta;Interferons;ISG15 gene;juvenile animal;Life;Mediating;Mediator;Microglia;Modeling;Molecular;Molecular Profiling;Molecular Target;Morphology;Mus;Nerve Degeneration;Nervous System;neural circuit;Neurodevelopmental Disorder;neuronal excitability;Neurons;novel;Nuclear;Nucleic Acids;Pattern;Pattern Recognition;Phagocytes;Phagocytosis;Phagolysosome;Phagosomes;pharmacologic;Phenocopy;Phenotype;Physiological;Play;postnatal;postnatal development;programs;receptor;Regulation;response;Risk;Role;Schizophrenia;Sensory;sensory cortex;Shapes;Signal Transduction;somatosensory;Somatosensory Cortex;Source;Stress;Synapses;synaptogenesis;Testing;Time;transcriptomic profiling;transcriptomics;type I interferon receptor;Vibrissae;Viral;Work

PROJECT_TITLE: Physiologic roles of Type I interferon responsive microglia in brain development

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: DURHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Using zebrafish as a model, this study will characterize the mechanical properties of the notochord vacuolated cells in live embryos and investigate their physical response to mechanical and genetic perturbations. This work will contribute to our understanding of spine formation and the origin of vertebral malformations.

PI_NAMEs: ZAREIESFANDABADI, PARSA  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TITLE: Investigating the Mechanical Properties of Vertebrate Notochord in Zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: NARRATIVE The Research Institute at Nationwide Children’s Hospital proposes a Muscular Dystrophy Specialized Research Center that builds upon our extensive expertise in therapeutic development, including first-in-human gene therapies, with a Shared Resource Core that develops critical patient-derived reagents for testing of new therapies, a Training Core that builds upon our nationally-recognized myology training program, and Projects intended to develop the next generation of therapies beyond microdystrophin gene therapy.

PI_NAMEs: FLANIGAN, KEVIN M (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Address;adeno-associated viral vector;Area;bench to bedside;Biological Markers;career development;Cells;circulating biomarkers;Collaborations;Communities;Community Outreach;Creativeness;Data;Dedications;Deletion Mutation;design;Development;Disease;Doctor of Philosophy;Dystrophin;dystrophinopathy;Early treatment;Educational Curriculum;effective therapy;Elements;Environment;Exons;extracellular vesicles;Fellowship;Fibroblasts;first-in-human;gene function;gene therapy;Gene Transduction Agent;Generations;Goals;Human;Humoral Immunities;improved;Infant;innovation;Institution;interest;Investigation;Left;Legal patent;Length;Limb-Girdle Muscular Dystrophies;micro-dystrophin;Mission;Modeling;Molecular;Monitor;mouse model;multidisciplinary;muscle form;Muscle function;muscle strength;Muscular Dystrophies;Myoblasts;Myopathy;next generation;novel;novel strategies;novel therapeutics;outreach program;Pathogenesis;Patients;Pediatric Hospitals;pre-clinical;preclinical development;prevent;programs;Property;Proteins;Protocols documentation;Quality of life;Reagent;reagent testing;recruit;Research;Research Institute;Research Personnel;Research Priority;Resource Sharing;Resources;RNA;RNA Splicing;Sampling;Science;Serum;Site;Small Nuclear RNA;Structure;success;synergism;Technology;Testing;Tetanus Helper Peptide;Therapeutic;therapeutic development;therapy development;Training;Training Programs;Transcript;transdifferentiation;transduction efficiency;Translating;United States National Institutes of Health;Universities;vector;Viral;web site;Woman;Work

PROJECT_TITLE: MDSRC for Next Directions in Muscular Dystrophy Research


PROJECT_TERMS: Address;adeno-associated viral vector;Advisory Committees;Advocacy;Awareness;bench to bedside;Biological Markers;Biopsy;career development;Cell Line;Cells;circulating biomarkers;Clinical;clinical development;clinical trial readiness;clinically significant;Collaborations;Communication;Communities;community engagement;Community Outreach;Dedications;design;Development;Disease;disease model;Doctor of Philosophy;Duchenne muscular dystrophy;Dystrophin;Early treatment;Educational Curriculum;Elements;Environment;Evaluation;Exclusion;Exons;extracellular vesicles;Faculty;Family;Fellowship;Fibroblasts;Functional disorder;Gene Delivery;gene function;gene therapy;Gene Transduction Agent;Generations;Genetic Enhancer Element;Goals;Health;Human;Humoral Immunities;improved;Individual;Infant;Institution;interest;Investigation;Left;Legal patent;Length;Limb-Girdle Muscular Dystrophies;Mediating;micro-dystrophin;Mission;mouse model;multidisciplinary;Muscle;Muscle function;muscle strength;Muscle Weakness;Muscular Dystrophies;Myopathy;Neuromuscular Diseases;next generation;novel;Ohio;outreach program;Pathogenesis;patient outreach;Patients;Pediatric Hospitals;Plasma;Postdoctoral Fellow;pre-doctoral;prevent;Process;programs;prospective;Proteins;Protocols documentation;Reagent;Recording of previous events;Research;research clinical testing;Research Institute;Research Personnel;Resources;RNA Splicing;Scientist;Serum;Site;Small Nuclear RNA;Source;Specimen;Structure;success;synergism;Technology;Therapeutic;therapy development;Time;Tissue Banks;Training;training opportunity;transduction efficiency;Translating;treatment strategy;United States National Institutes of Health;Universities;uptake;vector;web site

PROJECT_TITLE: MDSRC Administrative Core


PI_NAMEs: HARPER, SCOTT Q (contact)

PROJECT_TERMS: Award;biobank;Biology;Cardiac;Career Mobility;Cell Line;Cities;Clinical;clinical training;Collaborations;Communities;Country;design;Development;Doctor of Philosophy;Educational process of instructing;Educational workshop;Environment;Faculty;Fellowship;Fibroblasts;Foundations;Funding;Funding Opportunities;Future;gene therapy;Goals;graduate school;graduate student;Guidelines;Health;High School Student;Home;Human;improved;induced pluripotent stem cell;Institution;Laboratories;Leadership;lectures;medical schools;meetings;member;Mind;multidisciplinary;Muscle;Muscular Dystrophies;Myopathy;Neurology;neuromuscular;Neuromuscular Diseases;next generation;Ohio;Pathogenesis;Pediatric Hospitals;Physicians;Postdoctoral Fellow;Productivity;programs;recruit;Research;Research Institute;Research Personnel;Role;Schools;Scientist;Structure;Students;success;synergism;Training;Training Activity;training opportunity;Training Programs;Travel;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;US State;Writing

PROJECT_TITLE: MDSRC Training Core


PI_NAMEs: WEIN, NICOLAS  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Applications Grants;biobank;Biopsy;Blood Banks;cell bank;cell immortalization;Cell Line;Cell Physiology;Cells;Center for Translational Science Activities;Clinic;Collaborations;Communities;Data;Dermal;differentiation protocol;Disease;Doctor of Philosophy;Environment;Extracellular Matrix;Fibroblasts;Folic Acid;Formulation;fukutin related protein;Funding;Gene Expression Profile;gene therapy;Genes;Goals;Grant;Human;Human Cell Line;human tissue;improved;Individual;induced pluripotent stem cell;Industry Collaboration;inhibitor;Institution;Institutional Review Boards;Institutional support resources;International;knowledge base;Laminin;Lentivirus Vector;matrigel;Methods;Mission;Modeling;Muscle;Muscle Cells;Muscle Fibers;Muscular Dystrophies;Myoblasts;MyoD Protein;myogenesis;Myogenic Regulatory Factors;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;novel strategies;Pathogenesis;Pathogenicity;Patients;Pattern;Pediatric Hospitals;Plasma;Platelet-Derived Growth Factor;Process;Production;Protocols documentation;Quality Control;Reagent;Research;Research Institute;Research Personnel;Resource Sharing;Resources;Sampling;scaffold;Serum;skeletal;skeletal muscle differentiation;skin biopsy;small molecule;Specimen;System;Techniques;Telomerase;TGFBR1 gene;transcriptome sequencing;transdifferentiation;transgene delivery;Transgenes;Translations;Variant;Work

PROJECT_TITLE: Muscular Dystrophy Cell Line and Serum Banking Core


PI_NAMEs: MARTIN, PAUL TAYLOR (contact)

PROJECT_TERMS: advanced disease;Applications Grants;Back;Clinical;Clinical Trials;congenital muscular dystrophy;Core Facility;Data;Data Set;Dependovirus;design;Development;Disease;Disease Outcome;disease phenotype;disorder prevention;Dose;Early treatment;experimental study;falls;FDA approved;Follistatin;Formulation;fukutin related protein;Gene Expression;gene function;Gene Proteins;gene replacement;gene replacement therapy;gene therapy;gene therapy clinical trial;Genes;Goals;Hour;improved;Limb-Girdle Muscular Dystrophies;Liver;loss of function mutation;MDC1C;Modeling;mouse model;Mus;Muscle;muscle form;Muscle function;muscle strength;Muscular Atrophy;Muscular Dystrophies;Mutate;Myopathy;novel;Other Genetics;overexpression;Patients;Pediatric Hospitals;Phase;pre-clinical;pre-Investigational New Drug meeting;prevent;promoter;Research;Safety;safety study;Satellite Viruses;Serum;Symptoms;Technology;Testing;Therapeutic;Tissues;Toxicology;Translations;treatment optimization;vector;Walking;Wild Type Mouse

PROJECT_TITLE: (Project 1) Bicistronic Gene Therapies for the Muscular Dystrophies


PROJECT_TERMS: adeno-associated viral vector;adenovirus mediated delivery;Age;Alleles;Animals;Becker Muscular Dystrophy;boys;Cell Line;Clinical;Communities;Data;Dependovirus;design;Development;Disease;Duchenne muscular dystrophy;Dystrophin;dystrophinopathy;efficacy evaluation;efficacy testing;Electrophysiology (science);Engineering;Evaluation;exon skipping;exon skipping therapy;Exons;Fiber;Fibroblasts;first-in-human;Future;gene therapy;Genes;Goals;Hand;Histologic;Human;individual patient;Infant;interest;Lead;lead candidate;Length;mdx mouse;micro-dystrophin;Modeling;mouse model;Mus;Muscular Dystrophies;Mutation;nonhuman primate;novel;Open Reading Frames;Outcome;patient population;Patients;personalized medicine;Phenotype;pre-clinical;preclinical efficacy;protein expression;Protein Isoforms;Proteins;Publishing;rare variant;Reporting;Research;Research Personnel;response;RNA Splicing;Rod;Serum;Small Nuclear RNA;Spectrin;success;Therapeutic;therapeutic development;therapy development;therapy outcome;Time;tool;Toxic effect;vector;Western Blotting;Work;X Chromosome

PROJECT_TITLE: (Project 2) Development of U7snRNA Vectors for Dystrophinopathy


PI_NAMEs: SAAD, NIZAR  (contact)

PROJECT_TERMS: adeno-associated viral vector;adenovirus mediated delivery;Adrenal Cortex Hormones;Adverse event;Affect;Age;Antibodies;Automobile Driving;Biological Markers;biomarker identification;Blood Vessels;boys;Capsid;Cell Line;Cells;Clinical;clinical outcome measures;Clinical Trials;comparative;Confounding Factors (Epidemiology);Consumption;Correlation Studies;Creatine Kinase;Data;delivery vehicle;Development;Disease;Disease Progression;Dose;Duchenne muscular dystrophy;Dystrophin;dystrophinopathy;exon skipping;extracellular vesicles;Fibroblasts;Functional disorder;functional outcomes;gene replacement therapy;gene therapy;Generations;Genes;Goals;Hepatotoxicity;Humoral Immunities;Immunity;immunogenicity;improved;Intramuscular Injections;intravenous injection;Length;Link;Lipid Bilayers;Longitudinal Studies;Mediating;Membrane;micro-dystrophin;minimally invasive;Molecular;molecular marker;Molecular Profiling;Monitor;Mus;Muscle;Muscle Contraction;Muscular Dystrophies;muscular dystrophy mouse model;Mutation;Myoblasts;Myopathy;new therapeutic target;next generation;novel;Oligonucleotides;Organ;Organ Specificity;Outcome;Outcome Measure;particle;patient stratification;Patients;Plasma;Population;prevent;Principal Investigator;Production;Prognosis;prospective;Proteins;Research;Resource Sharing;RNA;Role;Serum;Serum Proteins;Surrogate Endpoint;Testing;Therapeutic;therapeutic genome editing;Therapeutic Intervention;therapy development;Time;Tissues;transduction efficiency;Translating;Treatment Efficacy;Validation;vesicular release;Work

PROJECT_TITLE: (Project 3) Extracellular Vesicles in Monitoring and Treatment of Dystrophinopathy


NIH_SPENDING_CATS: Autoimmune Disease;Eye Disease and Disorders of Vision;Immunotherapy;Prevention

PHR: Clinical studies suggest that 85% of all dry eye disease cases are caused by some form of Meibomian Gland Dysfunction (MGD). Despite the high prevalence of MGD, its etiology remains unknown. This proposal will investigate for the first time the role of autoreactive CD4+ T cell that attack the Meibomian Glands, leading to MGD.

PI_NAMEs: COULSON-THOMAS, VIVIEN JANE;DE PAIVA, CINTIA S. (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Adoptive Transfer;Affect;aqueous;Area;Atrophic;Autoimmune;Autoimmune Diseases;Autoimmune Responses;autoreactive T cell;autoreactivity;Basal Cell;Blindness;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Proliferation;Cells;Chronic;Classification;Clinical Research;clinically significant;Data;design;Dropout;Dry Eye Syndromes;Etiology;evaporation;eye dryness;Film;High Prevalence;Immune;immune cell infiltrate;immunodeficiency;Infiltration;Inflammation;Inflammatory;Inflammatory Response;innovation;irritation;Knockout Mice;Lacrimal gland structure;Lead;Left;Lipids;Measurable;Mediating;meibomian gland;meibomian gland dysfunction;Modeling;Morphology;mouse model;Mus;novel;ocular pain;ocular surface;Pathogenesis;Patients;Persons;Play;prevent;Preventive therapy;Preventive treatment;Procedures;Production;Public Health;Regulatory T-Lymphocyte;Research;Role;Severities;Sjogren's Syndrome;Symptoms;T cell infiltration;T-Lymphocyte;Time;Tissues;Wild Type Mouse;Work

PROJECT_TITLE: Pathobiology of autoimmune Meibomian gland dysfunction

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

PHR: PROJECT NARRATIVE State prenatal drug policies are currently being debated and enacted in the absence of rigorous evidence on these laws’ impacts on pregnant and postpartum populations and their infants. In this project, we study the effects of state prenatal drug policies on drug screening, substance use disorder diagnosis and treatment, overdose, and maternal and child health care use. We also assess state implementation of a significant recent federal child welfare policy reform across states with varying prenatal drug law contexts.

PI_NAMEs: BANDARA, SACHINI  (contact);KENNEDY HENDRICKS, ALENE

PROJECT_TITLE: CE24-012 - ASSESSING THE IMPLEMENTATION AND OUTCOMES OF STATE PRENATAL DRUG USE LAWS

STUDY_SECTION_NAME: Special Emphasis Panel[ZCE1 AW (12)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The goal of the proposed research is to develop the technologies necessary to allow multiple bioluminescent reporters to be used simultaneously in the same cell or organism. This technology will enable the observation and control of two or more activities at once, allowing researchers to gather much more informative data when probing the complex dynamics of the brain and other systems in animal models of human disease.

PI_NAMEs: PRESCHER, JENNIFER ;SHANER, NATHAN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Alzheimer's Disease;Amyotrophic Lateral Sclerosis;analog;Animal Model;Biochemical;Biological;Biological Assay;Biological Availability;biological systems;Bioluminescence;Biomedical Research;Brain;Breathing;cell type;Cells;Central Nervous System;chemical synthesis;Chemistry;coelenterazine;Communities;Complex;complex biological systems;Conceptions;Consumption;Coupled;Data;design;Directed Molecular Evolution;Electrophysiology (science);Elements;Energy Transfer;Engineering;Enzymes;Evolution;experimental study;Family;Fluorescence;Fluorescent Probes;Goals;human disease;human model;Image;Imaging technology;Implant;improved;innovation;Lasers;Light;light emission;Luciferases;luciferin;marine;Membrane;model design;Molecular;Molecular Weight;multiplexed imaging;mutant;Neurodegenerative Disorders;neurodevelopment;next generation;non-invasive imaging;novel;optical fiber;optogenetics;Organism;Ostracods;oxidation;Parkinson Disease;Pathway interactions;Protein Engineering;Proteins;Reagent;Refractory;Reporter;Research;Research Personnel;scaffold;sensor;Shrimp;Side;Signal Transduction;small molecule;Specificity;Spinal cord injury;System;Target Populations;targeted delivery;Technology;Testing;Tissues;tool;Traction;Variant;Work

PROJECT_TITLE: An Orthogonal Bioluminescent Platform For Multiplexed Imaging And Control

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (08)]


ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Despite scientific evidence supporting reduction in overdose risk with use of medications for opioid use disorder and engagement with harm reduction approaches, patient uptake remains limited. Concerned significant others (CSOs) of people who use drugs (PWUD) have the potential to provide positive social support to improve overdose risk behavior through treatment and harm reduction engagement if they are given adequate training and resources. Using community-engaged research methodology, we propose to develop and evaluate a novel brief multi-component digital intervention for the CSOs of PWUD, aiming to reduce stigma around evidence-based medications and harm reduction, provide resources on community and health system navigation, teach positive communication skills, and improve caregiver well-being.

PI_NAMEs: LAGISETTY, POOJA  (contact);MADDEN, ERIN F

PROJECT_TITLE: CE24-013 - Developing and Evaluating the Concerned Caregivers Education for Resource Navigation (ConCERN) Intervention for Preventing Overdose

STUDY_SECTION_NAME: Special Emphasis Panel[ZCE1 AW (03)]