NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

PROJECT_TERMS: Age;age related;Antibodies;Archives;Behavior;biobank;Bioinformatics;Biological Markers;Cells;cellular imaging;Chronology;Clinical;clinically relevant;comorbidity;comparative;Data;Data Analyses;data sharing;Dermatopathology;Diagnostic;digital technology;Ensure;Epigenetic Process;Epitopes;Event;experience;Experimental Models;experimental study;Feedback;Formalin;Fortification;Functional disorder;Funding;genomic profiling;Histology;Human;Image;Imaging technology;Immunology;In Situ;In Vitro;in vivo;Infrastructure;innovation;insight;Institution;Integumentary system;Label;Lead;Molecular;Morphology;mouse model;multiplexed imaging;Mus;Natural regeneration;novel;Paraffin Embedding;Pathology;Pathway interactions;Patients;Physicians;Process;prospective;Proteomics;Protocols documentation;Recording of previous events;repaired;Research;Research Personnel;Resolution;Resources;response;Role;Sampling;Scanning;Scientist;Services;skills;Skin;Skin Aging;Skin Cancer;skin disorder;skin healing;Specimen;Standardization;stem cell biology;stem cell exhaustion;stem cells;Structure of thyroid parafollicular cell;success;targeted treatment;Technology;technology development;technology platform;Time;Tissue imaging;Tissues;Training;Treatment Efficacy;United States National Institutes of Health;Validation;Visual;web site;wound healing

PROJECT_TITLE: Core C Cell and Tissue Imaging and Analysis


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PI_NAMEs: MANDINOVA, ANNA  (contact)

PROJECT_TERMS: absorption;Acetyl-CoA Carboxylase;Address;Adult;Affect;Age;age effect;age related;age related changes;age related decline;aged;Aging;Aptitude;Artificial Organs;Artificial skin;Automobile Driving;Candidate Disease Gene;Carnitine Palmitoyltransferase I;Cell Aging;Cells;Chromatin Structure;Chronology;Coenzyme A-Transferases;Complex;Data;Defect;Dermal;Deterioration;Development;Elderly;Enzymes;epidermal stem cell;Epidermis;Epigenetic Process;Equilibrium;Esthesia;Excretory function;exhaustion;Failure;fatty acid oxidation;Gases;gene editing technology;gene function;Genes;Genetic Transcription;Glycolysis;Homeostasis;Human;Human body;Impairment;Impotence;In Situ;in utero;In Vitro;in vivo;Injections;keratinization;keratinocyte;Keto Acids;knock-down;knockout gene;life span;lipid metabolism;loss of function;Mesenchymal Stem Cells;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;model organism;Modeling;Molecular;mouse model;Mus;Natural regeneration;novel;Organ;Organism;overexpression;Oxidative Phosphorylation;Phenotype;Physiological;Population;Process;progenitor;Regenerative capacity;regenerative healing;Regenerative response;Regulation;repository;Resistance;Respiration;response;response to injury;Role;self-renewal;Skin;Skin Aging;skin barrier;Skin injury;skin regeneration;stem;stem cell aging;stem cell population;stem cells;Structure;succinyl-coenzyme A;System;Technology;Testing;theories;Thick;tissue regeneration;Tissues;Transcription Alteration;transcriptome;transcriptome sequencing;ultrasound;Water;wound healing

PROJECT_TITLE: Metabolic Reprogramming and Regeneration in the Aged Epidermis


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: This application is for the fourth competitive renewal of our training program, now entitled “Training in HIV Pathogenesis, Vaccination and Cure”. Over the last 15 years the program has trained 79 distinguished young scientists, the great majority of whom are continuing in research. HIV/AIDS continues to be a severe health burden in the US and globally; experts on HIV/AIDS trained by our program are well positioned to lead the effort to reduce this disease burden.

PI_NAMEs: BUSHMAN, FREDERIC D (contact);RILEY, JAMES L.

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: HIV;Pathogenesis;Vaccination

PROJECT_TITLE: HIV Pathogenesis, Vaccination and Cure

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Aging;Cancer;Genetics

ORG_CITY: SAN ANTONIO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: The goal of this application is to pursue our seminal findings by assessing the specific mechanisms that underlie the anti-cancer effects of thioredoxin (Trx)1 and Trx2 down-regulation in mice. We will investigate whether reduced Trx in the cytosol and mitochondria enhance apoptosis/autophagy, which reduce damaged cells and cellular damages leading to less genomic instability. The changes in these pathways could lead to a reduction in age-related spontaneous tumor development in mice.  This study is the first project to test the beneficial effects of reduced antioxidant in both the cytosol and mitochondria on age-related spontaneous tumor development using unique and well-defined knockout mouse models. The outcome of this project could provide critical information in understanding the cellular basis for cancer prevention and therapy in the elderly population; many of whom have an increased risk of various age-related diseases, especially cancer.

PI_NAMEs: IKENO, YUJI  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: age related;age-related disease;Aging;Animals;anti-cancer;antioxidant enzyme;Antioxidants;Apoptosis;Attenuated;Autophagocytosis;C57BL/6 Mouse;cancer prevention;cancer therapy;cell injury;Cells;Cysteine;Cytosol;Development;Disease;DNA;Down-Regulation;Elderly;Environment;Excision;extend lifespan;Female;Frequencies;Gene Expression;Genomic Instability;Goals;Growth;Health;healthspan;improved;Incidence;Intervention;Knockout Mice;LacZ Genes;life span;lipidomics;Lipids;male;Malignant Neoplasms;Mitochondria;Mole Rats;Molecular;mouse model;Mus;Mutation;novel;Outcome;overexpression;Oxidation-Reduction;oxidative damage;Oxidative Stress;Pathologic;Pathway interactions;pharmacologic;Physiological;Play;Population;protein function;Proteins;Reactive Oxygen Species;Reporting;Research;Risk;Role;Seminal;Severities;Signal Pathway;Signal Transduction;Superoxide Dismutase;Testing;Tissues;tumor;TXN gene;Wild Type Mouse

PROJECT_TITLE: Reduced thioredoxin in both the cytosol and mitochondria: a key modulator of age-related cancer development in Trx1KO x Trx2KO mice?

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Aging;Clinical Research;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

PI_NAMEs: LIAN, CHRISTINE GUO (contact)

PROJECT_TERMS: 3-Dimensional;adenovirus mediated delivery;Age;age acceleration;age related;age-related disease;Aging;aging biomarker;aging process;aging reversal;animal old age;Area;ATAC-seq;Bioinformatics;Biological Markers;Biological Models;Biology of Aging;biomarker validation;bioprinting;cell age;cell behavior;Cell Cycle Kinetics;cell type;Cells;Characteristics;Chromatin Structure;chronic wound;Chronology;Cicatrix;Clinical;Collaborations;Complex;CpG Islands;Cutaneous;Data;demethylation;Dermal;Dermatopathology;Development;DNA;DNA Methylation;Elderly;Enzymes;epidermal stem cell;epigenetic clock;Epigenetic Process;epigenetic regulation;experience;Experimental Models;Family;Fibroblasts;Foundations;functional restoration;Gene Expression Profile;gene therapy;Genes;Genetically Engineered Mouse;Goals;Hair follicle structure;healing;Health;histone modification;Human;human old age (65+);human tissue;Hypermethylation;Image Analysis;Impaired wound healing;improved;in vivo;juvenile animal;keratinocyte;Maintenance;Mediating;Melanoma;member;Mesenchymal Stem Cells;Metabolic;Methylation;methylome;Modification;Morbidity - disease rate;Morphology;mouse model;multiplexed imaging;Mus;Nature;novel;novel strategies;Pattern;Play;Polycomb;Pre-Clinical Model;Premature aging syndrome;Process;programs;Proliferating;Promoter Regions;Recording of previous events;regeneration potential;regenerative healing;Regulation;Rejuvenation;Reporting;Research Personnel;Resolution;response;retinal neuron;Role;scaffold;Site;Skin;Skin Aging;Skin Cancer;skin disorder;skin healing;skin regeneration;stem;stem cell aging;stem cell biology;stem cell function;stem cells;synergism;Testing;Therapeutic Effect;therapeutic evaluation;Time;Tissues;transcriptome;Transgenic Organisms;translational approach;translocase;Untranslated RNA;Vision;wound healing;Wound models;Xenograft procedure

PROJECT_TITLE: Epigenetic Regulation of Skin Regeneration


NIH_SPENDING_CATS: Aging;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Wound Healing and Care

PI_NAMEs: FRANK, MARKUS H. (contact)

PROJECT_TERMS: Address;Adult;adult stem cell;Age;age related;Age Years;age-related disease;Aging;Allogenic;angiogenesis;Animal Model;Anti-Inflammatory Agents;appendage;Autologous;Binding;Cell Aging;Cell Compartmentation;Cell Differentiation process;Cell Maintenance;Cell membrane;Cell Separation;Cell surface;Cell Therapy;Cells;Chronic;chronic wound;Clinical Trials;Data;Dermal;Dermis;Development;Disease;Documentation;Elasticity;Employment;Endowment;Epidermis;Epigenetic Process;experimental study;Family member;Foundations;Frequencies;Functional disorder;Genetic;Germany;Hair;Health;Homeostasis;Human;Immune;immunoregulation;Impaired wound healing;Impairment;Inflammaging;Investigation;Knockout Mice;Membrane Proteins;Membrane Transport Proteins;Mesenchymal Stem Cell Transplantation;Mesenchymal Stem Cells;Modeling;Molecular;mouse model;Mus;Natural regeneration;non-healing wounds;novel;older patient;Organism;Pathway interactions;Patients;Pharmaceutical Preparations;pre-clinical;Prevention;Prospective Studies;rational design;Receptor Protein-Tyrosine Kinases;regenerative;Regenerative capacity;regenerative healing;Regenerative Medicine;regenerative tissue;Regenerative wound healing;repaired;Research;Role;self-renewal;Signal Pathway;Signal Transduction;Skin;Skin Aging;skin disorder;Skin injury;skin regeneration;skin wound;Somatic Cell;stem cell aging;stem cell biology;stem cell population;Stem cell transplant;stem cells;Testing;Therapeutic;Tissue Differentiation;tongue papilla;translational impact;translational potential;Varicose Ulcer;vasculogenesis;Vasculogenic;Venous Insufficiency;wound;wound healing

PROJECT_TITLE: Stem Cell Integral Membrane Transporter ABCB5 and Dermal Regeneration


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurosciences;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE St. Louis encephalitis virus (SLEV) is a re-emerging mosquito-borne flavivirus that causes a spectrum of manifestations in people ranging from febrile illness to encephalitis and death. To circumvent limitations of existing models, the goal of this project is to develop immunocompetent mouse models of SLEV using recombinant collaborative cross mice to recapitulate the spectrum of human disease outcomes and to understand virus kinetics, tropism, pathology, and innate immune responses that associate with protection from neurologic disease. The outcome of this project will the development of new human-relevant mouse models of SLEV which can be further used to study the spectrum of pathogenesis, define virus-host interactions and host genetic determinants of susceptibility and severity, test interventions like therapeutics and candidate vaccines, and rapidly adapt to model human disease for other new or re-emerging encephalitic flaviviruses.

PI_NAMEs: COFFEY, LARK L (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Americas;animal tissue;Animals;Antibody titer measurement;Biological Response Modifiers;Blocking Antibodies;Blood;Brain;Bypass;Cells;Central Nervous System;Central Nervous System Diseases;Cessation of life;Clinical;cohort;Culicidae;cytokine;Development;Disease;disease model;Disease Outbreaks;Disease Outcome;Dose;Ebola;Encephalitis;Exhibits;experience;Fever;Flavivirus;Gene Expression;Gene Expression Profiling;Genes;Genetic Determinism;Genetic Variation;Goals;Human;human disease;Human Genetics;human model;IFNAR1 gene;Immune;Immune response;Immunocompetent;immunodeficiency;Immunodeficient Mouse;immunological diversity;Immunophenotyping;Inbred Mouse;Inbreeding;Infection;Influenza;innate immune mechanisms;Innate Immune Response;Interferon alpha;Interferon Receptor;Interferons;Intervention;Kidney;Kinetics;Lesion;Link;long-term sequelae;Measures;Mediating;Mediator;Modeling;mosquito-borne;mouse model;Mus;Mutation;Natural Immunity;Nervous System Disorder;neurovirulence;novel;Outcome;Pathogenesis;Pathology;Periodicals;Persons;Phenotype;Population;Powassan virus;Predisposition;Property;Proteins;receptor;Recombinant Inbred Strain;Recombinants;Reproducibility;response;Role;sensor;Serial Passage;Serum;Severities;Severity of illness;Signal Transduction;Spleen;St. Louis Encephalitis Virus;Testing;Therapeutic;Time;Tissues;tool;Translating;transmission process;Tropism;vaccine candidate;Vaccines;Viral;viral genomics;Virus;Virus Diseases;virus genetics;virus host interaction;West Nile virus;ZIKA;Zoonoses

PROJECT_TITLE: Collaborative cross mice as a new model for diverse human outcomes of St. Louis encephalitis virus disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VDT-Q(01)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Kidney Disease

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Patients with chronic kidney disease frequently develop heart failure with preserved ejection fraction, which increases hospitalizations and shortens lifespan. The circulating metabolome, which constitutes small molecules that can modulate tissue function, is altered in patients with chronic kidney disease. To shed light onto possible new treatments for heart failure in patients with chronic kidney disease, we will study whether an altered metabolome in patients with chronic kidney disease contributes to heart failure with preserved ejection fraction in this high risk population.

PI_NAMEs: MEHTA, RUPAL  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: acylcarnitine;adjudication;Advisory Committees;Age;American;Area;Biometry;Cardiac;cardiac magnetic resonance imaging;Cardiopulmonary;Cardiovascular Diseases;cardiovascular health;Cardiovascular Manifestation;career development;Chronic Kidney Failure;Chronic Kidney Insufficiency;Clinical;Clinical Trials;cohort;Cohort Studies;Collaborations;Committee Members;Data;Development;dimethylarginine;Dose;Echocardiography;EFRAC;Energy Metabolism;Environment;Epidemiology;epidemiology study;Event;Exercise Test;experience;fatty acid oxidation;Follow-Up Studies;Functional disorder;Future;Gender;Glucose;Goals;Grant;Heart Atrium;Heart failure;heart function;Hemoglobin;high risk population;Homeostasis;Hospitalization;Hypertension;improved;Individual;insight;Institution;Intervention;Intervention Studies;Investigation;Kidney;Knowledge;Left;Left Ventricular Mass;life span;Light;Link;Measures;medical schools;Medicine;Mentors;Mentorship;Metabolic;Metabolism;metabolome;metabolomics;Minerals;Modification;mortality;Nephrology;Nitric Acid;novel;Participant;Pathogenesis;Pathway interactions;Patient Care;patient oriented;patient oriented research;Patients;Phenotype;Physicians;population based;preservation;professor;programs;Randomized;Renal function;Research;research study;response;Risk;Scientist;skills;small molecule;Societies;Sodium;Sodium Chloride;standard of care;Structure;Subgroup;symporter;Syndrome;Testing;Therapeutic;therapeutic candidate;Time;Tissues;Universities;Ventricular;Water

PROJECT_TITLE: Pathogenesis of Heart Failure with Preserved Ejection Fraction in Chronic Kidney Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative This proposal seeks to illuminate the cardiogenic cellular hierarchy and the gene regulatory networks that determine the origins and fates of distinct cardiovascular progenitor cells during heart development. Results from these studies will yield new insights into how disrupted cardiovascular regulatory networks lead to congenital heart disease and how they may be modified to develop treatments to improve patient outcome.

PI_NAMEs: CHI, NEIL C (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Accounting;Adult;Animals;Behavior;Biological Assay;Cardiac;cardiogenesis;Cardiovascular system;cell type;Cells;Chromatin;Communities;Computer Analysis;congenital anomaly;congenital heart abnormality;Data Set;Development;Early identification;Embryonic Development;Event;Family;Fluorescent in Situ Hybridization;Gene Expression Profile;gene network;gene regulatory network;Genes;Genetic study;Genetic Transcription;Goals;Heart;Human;human pluripotent stem cell;improved;In Situ;In Vitro;insight;Label;Lead;Maps;Mediating;Mesoderm;Modeling;Molecular;Monitor;Morphogenesis;multidisciplinary;Mus;Mutation;Newborn Infant;patient population;Patient-Focused Outcomes;Patients;Phenotype;Physicians;Population Heterogeneity;Process;progenitor;reconstruction;Regulatory Pathway;Research;Role;single cell analysis;Societies;Source;spatiotemporal;Specific qualifier value;stem cell model;stem cell population;stem cells;Structure;Systems Biology;transcriptome sequencing;Transgenic Organisms;translational framework;Validation

PROJECT_TITLE: Fine-scale Spatiotemporal Mapping of Cellular Regulatory Networks Directing Heart Development

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Maternal Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Substance use in pregnant women has increased over the past decade, highlighting the importance of efforts to understand how environmental and other exposures during pregnancy affect brain development and child outcomes. The PRELUDE consortium for the HEALthy Brain and Child Development study will recruit 2720 pregnant women in the 2nd and 3rd trimester and follow their children to age 10, using neuroimaging, behavioral assessments, EEG, biosample collection, and assessments of parent-child interaction and the home environment. This research will lead to greater understanding of factors affecting early childhood brain development, allowing targeted interventions and improved outcomes for mother-child dyads.

PI_NAMEs: ENGEL, STEPHANIE ;LIN, WEILI  (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: addiction;Address;adverse outcome;Affect;Age;Alcohol consumption;Arkansas;Behavior assessment;Behavioral;Biological;Biological Factors;Birth;Brain;Child;Child Development;Childhood;clinical care;Clinical Research;Cognitive;cohort;Collaborations;Collection;Communities;community engagement;Data;Data Analyses;Data Coordinating Center;data exchange;Dedications;design;Development;early childhood;Electroencephalography;Emotional;Enrollment;Ensure;Environmental Risk Factor;Ethics;Ethnic Origin;evidence base;Exposure to;Family;fetal;Funding;General Population;Genetic;Geography;Goals;Helping to End Addiction Long-term;high risk;high risk infant;high risk population;Home environment;Image;improved;improved outcome;Infant;insight;Institution;Intervention;Legal;Longitudinal Studies;Magnetic Resonance Imaging;Maternal and Child Health;Maternal Health;maternal outcome;maternal stress;Measures;Medical center;Mental Health;Mothers;neurodevelopment;neuroimaging;neurophysiology;North Carolina;nutrition;Opiate Addiction;Opioid;opioid misuse;Outcome;Parent-Child Relations;Parents;Participant;Pediatric Hospitals;Phase;Physiological;post pregnancy;Poverty;Pregnancy;Pregnant Women;prenatal;Prenatal care;prenatal experience;prenatal exposure;Protocols documentation;Public Health;Questionnaires;Race;recruit;Research;Research Institute;resilience;Resources;Risk;Risk Factors;risk minimization;Sample Size;Sampling;School-Age Population;Second Pregnancy Trimester;Series;Site;social;socioeconomic diversity;Speed;stem;substance use;Third Pregnancy Trimester;Tobacco;Toxic Environmental Substances;United States National Institutes of Health;Universities;Visit;wearable device;Work

PROJECT_TITLE: 5/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Infectious Diseases

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative This training grant supports the training of pre-doctoral students and post-doctoral fellows to develop rigorous methods in infectious disease epidemiology, surveillance, monitoring, and modeling so that they will be able to prevent and detect outbreaks of emerging epidemics.

PI_NAMEs: HOFMAN, ALBERT ;LIPSITCH, MARC  (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Infectious Disease Epidemiology

PROJECT_TITLE: Epidemiology of Infectious Diseases

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

PHR: PROJECT NARRATIVE While it is clear that LEMD2 L13R mutation results in cardiomyopathy, little is known as to the specific role of LEMD2 in cardiomyocytes and mechanisms by which LEMD2 L13R mutation leads to cardiomyopathy. Proposed studies are aimed at understanding the function of LEMD2 in the heart at the molecular, cellular, and physiological levels, and gaining insights into mechanisms by which LEMD2 mutation causes cardiomyopathy.

PI_NAMEs: CHEN, JU  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Ablation;Address;Adult;Affect;Age;Amino Acid Substitution;Apoptosis;Arginine;autosome;Biological Process;Birth;Body Weight;Cardiac Myocytes;Cardiomyopathies;Cell Nucleus;Chromatin;clinically relevant;Cytoplasm;Dilatation - action;Disease;Embryo;emerin;env Gene Products;Epigenetic Process;Functional disorder;Gene Expression Regulation;Gene Silencing;Genes;Goals;Heart;heart defect;heart function;Heterochromatin;histone modification;Human;human induced pluripotent stem cells;Impairment;induced pluripotent stem cell derived cardiomyocytes;insight;Integral Membrane Protein;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Lamins;Leucine;Link;Maintenance;man;Mechanics;Mediating;Membrane Proteins;Modeling;Molecular;Morphogenesis;mouse model;mutant;Mutant Strains Mice;Mutation;Myocardium;Myosin Heavy Chains;myosin light chain 2;new therapeutic target;Nonmuscle Myosin Type IIA;Nuclear;Nuclear Envelope;Nuclear Inner Membrane;Nuclear Lamina;Nucleoplasm;Pattern;Physiological;Play;Polymers;Protein Family;Proteins;Regulation;Reporting;Role;Shapes;Structure;System;Thick;Thinness;TNFSF5 gene;Ventricular;Weight;Xenopus laevis

PROJECT_TITLE: Nuclear envelope protein LEMD2 in heart

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Colorectal cancer (CRC) and (EAC) account for the majority of gastrointestinal cancer deaths but can be prevented with screening. For the screening tests to be most effective they need to be optimized for individuals at low-risk and high-risk for CRC and EAC; however, the current methods for CRC and EAC risk prediction have low accuracy. We propose to create an integrated and highly collaborative Biomarker Characterization Center to discover, validate and develop into clinic-ready assays, tests for accurate CRC and EAC risk prediction. We further propose to discover and validate tests based on simple brushing samples of the esophagus that can detect a nascent cancer condition called high grade dysplasia (HGD) and early EAC in people with Barretts esophagus (BE), a high risk precancerous condition for EAC, which will decrease deaths from EAC and the burden of BE surveillance.

PI_NAMEs: GRADY, WILLIAM MALLORY (contact);YEUNG, CECILIA C

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: adenoma;Affect;Age;Age Years;Barrett Esophagus;Biological Assay;Biological Markers;Cancer Etiology;Cancer Prevention Trial;Cessation of life;Chronic;CLIA certified;clinic ready;Clinical;Collaborations;Colon;colon cancer patients;colon cancer screening;Colonoscopy;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;colorectal cancer treatment;cost;cost effective;Cytology;detection assay;Development;Devices;Dysplasia;early detection biomarkers;Early Detection Research Network;Early Diagnosis;Economics;Effectiveness;effectiveness evaluation;Eligibility Determination;Endoscopy;Esophageal Adenocarcinoma;esophageal cancer prevention;Esophageal Precancerous Condition;Esophagus;Familial Adenomatous Polyposis Syndrome;Family history of;financial toxicity;Gastroesophageal reflux disease;Goals;Healthcare;Healthcare Systems;Hereditary Neoplastic Syndromes;Hereditary Nonpolyposis Colorectal Neoplasms;High grade dysplasia;high risk;high risk population;Histologic;improved;Incidence;Individual;Lesion;Malignant neoplasm of esophagus;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Methods;Modeling;Morbidity - disease rate;mortality;Patients;Persons;Phase;Population;premalignant;prevent;preventable death;Prevention;Prevention program;Program Efficiency;Progress Reports;progression risk;Recommendation;Recording of previous events;Resources;Risk;Risk Factors;Risk Marker;risk prediction;risk stratification;Sampling;screening;Screening for cancer;screening program;Serrated Adenoma;social;standard of care;Stress;success;Surveillance Program;Survival Rate;System;Testing;Treatment Cost;trend;Tubular Adenoma;United States National Institutes of Health;virtual

PROJECT_TITLE: Biomarkers for optimizing risk prediction and early detection of cancers of the colon and esophagus


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Esophageal Cancer;Prevention;Rare Diseases

PI_NAMEs: GRADY, WILLIAM MALLORY (contact)

PROJECT_TERMS: Administrative Coordination;Administrator;Biological Assay;Biological Markers;biomarker discovery;biomarker validation;Cancer Intervention and Surveillance Modeling Network;CLIA certified;Clinical;clinical biomarkers;clinical development;Collaborations;colon cancer screening;Communication;Data;Data Analyses;Data Commons;Data Coordinating Center;data dissemination;data sharing;data submission;Development;Early Detection Research Network;Early Diagnosis;Education;Environment;Funding;Funding Agency;Future;Industrialization;industry partner;innovation;Institution;interest;Letters;Malignant neoplasm of esophagus;Malignant neoplasm of gastrointestinal tract;meetings;member;Mission;operation;organizational structure;Process;Productivity;programs;protocol development;Rana;Research;Research Personnel;risk prediction;Running;Scientist;Screening for cancer;Structure;success;System;Teleconferences;United States National Institutes of Health;Validation;validation studies;Work

PROJECT_TITLE: Administrative Core-Biomarkers for optimizing risk prediction and early detection of cancers of the colon and esophagus


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Esophageal Cancer;Genetic Testing;Genetics;Human Genome;Precision Medicine;Prevention;Rare Diseases

PROJECT_TERMS: adenoma;Age;Aneuploidy;Barrett Esophagus;base;Biological Assay;Biological Markers;biomarker development;biomarker identification;biomarker validation;Biopsy;Biopsy Specimen;Cancer Etiology;cancer therapy;candidate identification;candidate marker;Cessation of life;Clinical;clinically relevant;cohort;Colon;colon cancer risk;colon cancer screening;Colon Carcinoma;Colonic Adenoma;Colonoscopy;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;cost effective;Cytology;Data;Death Rate;Detection;Devices;DNA Markers;DNA Methylation;Dysplasia;early detection biomarkers;Early Detection Research Network;Early Diagnosis;Esophageal Adenocarcinoma;Esophagus;follow-up;Funding;Genetic Markers;genomic locus;Goals;High grade dysplasia;high risk;Incidence;Individual;laboratory development;Lesion;Life;Malignant neoplasm of esophagus;Malignant neoplasm of gastrointestinal tract;Methylation;methylation biomarker;Molecular;molecular marker;mortality;Mucous Membrane;Natural History;novel;Patients;Performance;Persons;Phase;phase IV trial;predictive marker;Prevention;Progressive Disease;prospective;Prospective cohort;Recurrence;Retrospective cohort study;Risk;Risk Marker;risk prediction;risk stratification;risk variant;Sampling;screening;Screening for cancer;screening program;Sensitivity and Specificity;Stable Disease;Surveillance Program;Testing;Vision

PROJECT_TITLE: Biomarker Development Laboratory


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Nanotechnology;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Public Health Relevance Our overall goal is to improve patient outcomes through the development and evaluation of simplified sequencing workflows in order to facilitate early, appropriate drug-resistant tuberculosis treatment within national tuberculosis programs, and to preserve newer all oral treatment regimens.

PI_NAMEs: CHAKRAVORTY, SOUMITESH ;METCALFE, JOHN ZAPATA (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Acceleration;Address;Antimicrobial Resistance;Bar Codes;biobank;Biological Assay;Biological Containment;Calibration;Capital;Cause of Death;Cells;Characteristics;Clinical;clinical application;Clinical assessments;Clinical Management;Clinical Trials;Complex;Containment;cost;Country;Cytolysis;Data;Decentralization;Detection;Development;Diagnostic;DNA;drug repurposing;Drug resistance in tuberculosis;Drug Targeting;Evaluation;Fluoroquinolones;Funding;Genes;Genetic;genome sequencing;genomic locus;Goals;Growth;Health Status;Healthcare;HIV;Hot Spot;improved;improved outcome;industry partner;Industry Standard;ineffective therapies;Infrastructure;Investments;Laboratories;Length;Libraries;life span;Linezolid;Methods;Microfluidics;Molecular;Mycobacterium tuberculosis;nanopore;next generation sequencing;novel;Oral;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Philippines;portability;Predisposition;Preparation;preservation;primary outcome;product development;programs;prospective;prototype;public health emergency;public health relevance;Pyrazinamide;Pyrazinamide resistance;Reagent;Recommendation;Reference Standards;Regimen;Research;Resistance;Resistance profile;Rifampicin resistance;sample collection;Sampling;scale up;secondary outcome;Sensitivity and Specificity;sequencing platform;South Africa;Specimen;Speed;Sputum;success;System;Technical Expertise;Technology;Testing;Time;Treatment outcome;Treatment Protocols;Tuberculosis;tuberculosis diagnostics;tuberculosis drugs;tuberculosis treatment;United States National Institutes of Health;whole genome

PROJECT_TITLE: A novel cartridge-based sequencing solution for decentralized M. tuberculosis resistance detection

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Hypertension;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Uncontrolled hypertension, the leading risk factor for death, is exceedingly common among people living with HIV (PLWH) in sub-Saharan Africa (SSA). Despite the pressing need to develop hypertension care models for PLWH in SSA, few effective interventions targeting this population exist. Using an implementation science approach, this project will adapt an evidence-based hypertension intervention, proven effective in other settings, for integration within HIV clinics to improve hypertension control among Tanzanians living with HIV.

PI_NAMEs: HERTZ, JULIAN T;MANAVALAN, PREETI ;MMBAGA, BLANDINA THEOPHIL;THIELMAN, NATHAN M (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adopted;Adoption;Adult;Africa South of the Sahara;Anti-Hypertensive Agents;Anti-Retroviral Agents;Area;arm;Asia;attenuation;Blood Pressure;blood pressure control;Blood Pressure Monitors;blood pressure reduction;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;care systems;Caring;Cessation of life;Chronic Disease;Clinic;Clinical;clinical infrastructure;Cluster randomized trial;cohort;Communities;Community Health;Community Health Aides;comorbidity;Consultations;Counseling;Country;Data;design;Diastolic blood pressure;Disease;Disease Management;early experience;Education;Educational Intervention;effective intervention;Effectiveness;effectiveness outcome;effectiveness/implementation trial;Elements;Enrollment;evidence base;Evidence based intervention;Face;feasibility trial;Health system;Healthcare Systems;HIV;Hybrids;Hypertension;hypertension control;hypertensive;implementation evaluation;implementation outcomes;implementation science;implementation/effectiveness;improved;Intervention;Investments;Knowledge;Maintenance;member;Methods;Modeling;mortality;multi-component intervention;new epidemic;optimism;Outcome;Participant;Patients;Persons;Pharmaceutical Preparations;Physicians;Population;Positioning Attribute;Preparation;Primary Health Care;Process;programs;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Priority;Risk;Risk Factors;Southeastern Asia;stem;Strategic Planning;Tanzania;Target Populations;Training;treatment center;United States National Institutes of Health;waist circumference;Work

PROJECT_TITLE: Adapting and Piloting an Evidence-based Intervention to Improve Hypertension Care among Tanzanians Living with HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Esophageal Cancer;Genetic Testing;Genetics;Health Services;Human Genome;Prevention;Rare Diseases

PI_NAMEs: YEUNG, CECILIA C (contact)

PROJECT_TERMS: Aberrant DNA Methylation;Address;Adherence;Aneuploidy;Barrett Epithelium;Barrett Esophagus;Biological Assay;Biological Markers;biomarker panel;Biopsy;Cancer Etiology;Carcinoma;Cessation of life;Clinical;Clinical Trials;Collaborations;Colon;colon cancer risk;colon cancer screening;Colonic Adenoma;Colonoscopy;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;Custom;design;Development;Diagnostic Reagent Kits;digital;DNA;DNA Markers;DNA Methylation;Dysplasia;early detection biomarkers;Early Detection Research Network;Early Diagnosis;Economic Burden;Ensure;Epigenetic Process;Esophageal Adenocarcinoma;Esophageal Intraepithelial Neoplasia;Esophagus;follow-up;Funding;Genetic Markers;Goals;High grade dysplasia;high risk;high risk population;improved;Individual;industry partner;Laboratories;Lesion;Life;Malignant neoplasm of esophagus;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Massive Parallel Sequencing;Measures;Methods;Methylation;methylation biomarker;methylation testing;mortality;Mucous Membrane;Mutation;novel;Pathology;patient stratification;Patients;Persons;Phase;Phase II/III Trial;phase IV trial;prevent;product development;programs;prospective;Protocols documentation;research clinical testing;Risk;risk prediction;risk stratification;risk variant;Sampling;screening;Screening for cancer;screening program;Serrated Adenoma;social;Testing;Tissue Sample;Tissues;Tubular Adenoma;Validation

PROJECT_TITLE: Biomarker Developmental Unit


NIH_SPENDING_CATS: Burden of Illness;Cardiovascular;Clinical Research;HIV/AIDS;Infectious Diseases;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: PORT-AU-PRINCE

ORG_COUNTRY: HAITI

ORG_FIPS: HA

ORG_NAME: GHESKIO CENTER

PHR: PROJECT NARRATIVE Persons with HIV have a higher risk of developing metabolic and cardiovascular diseases, which are leading causes of mortality among residents of low and middle-income countries (LMICs). Weight gain is common after starting integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy, which is increasingly being used for HIV treatment in LMICs. This study will assess the prevalence of cardiometabolic disease among persons with HIV who gain weight on INSTI-based regimens in LMICs, and the metabolic and lipid pathways contributing to weight gain.

PI_NAMEs: KOETHE, JOHN ;PIERRE, SAMUEL  (contact)

PROJECT_TERMS: Address;Americas;Amino Acids;antiretroviral therapy;Area;Argentina;Automobile Driving;Bioenergetics;Blood Pressure;blood pressure elevation;Body fat;Body Weight;Brazil;Carbohydrates;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Caribbean region;Central America;Chile;Clinic;Clinical;Clinical Research;comorbidity;Country;Data;Data Analyses;Desire for food;Development;Diastolic blood pressure;Diet;Disease;disorder risk;Dyslipidemias;Enrollment;Epidemic;Epidemiology;experience;Fasting;fasting plasma glucose;food security;Fumarates;General Population;Haiti;Haitian;Health;high body mass index;high risk;HIV;Honduras;Hospitals;Human;Hypertension;Immunology;improved;Incidence;Income;Infection;Inflammation;inflammatory marker;Infrastructure;inhibitor;innovation;Insulin Resistance;insulin sensitivity;Integrase;Laboratories;Lamivudine;Life Style;lifestyle factors;Link;lipid metabolism;lipidomics;Lipids;Liver diseases;low and middle-income countries;member;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolic syndrome;Metabolism;metabolomics;Mexico;mortality;multidisciplinary;Multiomic Data;nutrition;Outcome;Pathway interactions;Patients;Persons;Peru;phenotypic data;Physical activity;Prevalence;Prevention strategy;Prospective, cohort study;Regimen;Research;Research Activity;Research Personnel;Resources;Severities;Site;sociodemographic variables;South America;systemic inflammatory response;Tenofovir;treatment strategy;United States National Institutes of Health;Universities;Weight Gain;Woman

PROJECT_TITLE: Cardiometabolic Consequences And Pathway Of Weight Gain Associated With Dolutegravir-Based Antiretroviral Therapy In Haiti. A Collaborative Study Between GHESKIO And CCASAnet


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_DEPT: CHEMISTRY

PHR: NARRATIVE We will use multiscale all-atom molecular dynamics simulations as a `computational microscope,' to provide insights into the dynamics of the HIV-1 envelope protein (Env) that are unattainable with current experimental techniques. Together with top flight experimentalists, we will develop and simulate a series of models to explore the dynamics of Env as well as its interactions with its receptor, co-receptors and the cell glycocalyx, under physiological conditions. In addition, we will use advanced simulation techniques to optimize immunogen design as well as provide critical information about hitherto unseen therapeutic vulnerabilities in Env.

PI_NAMEs: AMARO, ROMMIE E (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Address;advanced simulation;AIDS prevention;Antigens;Back;Biology;Cells;Chimeric Proteins;Collaborations;Crowding;Cryo-electron tomography;Cryoelectron Microscopy;Data;Data Set;density;design;Disease;Elements;env Gene Products;Exhibits;experimental study;flexibility;Future Generations;Glycocalyx;Goals;Heparitin Sulfate;HIV;HIV vaccine;HIV-1;Human;Immune system;immunogenic;improved;in vivo;Infection;Infection prevention;infection rate;Influenza;insight;interest;Knowledge;Link;Methods;Microscope;Microscopy;model building;Modeling;molecular dynamics;Molecular Structure;Mucins;Mutate;novel;Outcome;Pattern;Persons;Physiological;Play;Polysaccharides;Post-Translational Protein Processing;Protein Dynamics;receptor;Resolution;Retroviridae;RNA;Scientist;Series;simulation;Site;small molecule;Structural Biologist;structural biology;Structure;Surface;Techniques;Therapeutic;Time;Translating;United States National Institutes of Health;Utah;Vaccines;Viral;Viral Fusion Proteins;Viral Proteins;Virion;Virus

PROJECT_TITLE: Multiscale Computational Microscopy of HIV-1


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The International Workshop on HIV Pediatrics is the only meeting entirely devoted to research in prevention and treatment of HIV infections in infants, children, and adolescents, making it the premier forum for the world’s leading researchers. By bringing together experts from different disciplines with presentations in a variety of formats, the meeting offers a collaborative setting where the latest developments are presented and junior investigators are supported and encouraged to continue their scientific work in this field.

PI_NAMEs: ABRAMS, ELAINE JANINE (contact)

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: 15 year old;Accounting;Acquired Immunodeficiency Syndrome;Adherence;Adolescence;Adolescent;Adult;Africa South of the Sahara;Age;Aging;AIDS prevention;antiretroviral therapy;Breast Feeding;Canada;Caring;case finding;Child;Child health care;Childhood;Clinical;Clinical Management;co-infection;Collaborations;Communities;Complex;COVID-19;Development;Diagnosis;Discipline;Educational workshop;ethnic minority;Evaluation;Faculty;Formulation;Future;girls;HIV;HIV anti-retroviral;HIV Infections;HIV-infected adolescents;Human immunodeficiency virus test;Income;Individual;Infant;Infection;innovation;International;International AIDS;Intervention;Leadership;low income country;meetings;member;men;multi-racial;next generation;Oral;Participant;Pattern;pediatric human immunodeficiency virus;pediatric human immunodeficiency virus infection;perinatal HIV;Perinatal Infection;Persons;Population;posters;Pregnancy;pregnant;prevent;Prevention;Prevention strategy;programs;racial minority;Regimen;Research;Research Personnel;Research Support;scale up;Schedule;Scholarship;social;Structure;success;symposium;transmission process;treatment strategy;uptake;Vertical Transmission;Viral;virtual;Walking;Woman;Work;young adult;young woman

PROJECT_TITLE: International Workshops on HIV Pediatrics

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Clinical Research;Diabetes;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative We have developed a network of adult and pediatric medical research institutions to form The Ohio State University Clinical Center (OSU CC). In a multidisciplinary collaboration with other clinical centers in the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer Clinical Centers (CSCPDPC- CCs) (U01), the OSU CC has helped developed 4 major observational studies during the initial funding cycle that address research gaps in our understanding of the exocrine pancreas. Specifically, the OSU CC seeks to confirm and validate proposed diagnostic biomarkers in chronic pancreatitis, pancreaticogenic diabetes and pancreas cancer.

PI_NAMEs: CONWELL, DARWIN LEWIS;HART, PHILIP A. (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abdominal Pain;Address;Adult;Aliquot;Ancillary Study;Applications Grants;Artificial Intelligence;Basic Science;Big Data Methods;Biological;Biological Markers;Cancer Research Infrastructure;Childhood;chronic pain;chronic pancreatitis;Clinical Cancer Center;clinical center;Clinical Sciences;Clinical Trials;Collaborations;Collection;Complement;Cross-Sectional Studies;Data;Data Collection;Development;Diabetes Mellitus;diagnostic biomarker;Disease;Enrollment;Epidemiology;Evaluation;Exocrine pancreas;Exocrine pancreatic insufficiency;Fibrosis;follow-up;Fostering;Functional disorder;Funding;Future;Goals;Grant;Inflammation;Infrastructure;insight;Institution;Interdisciplinary Study;Lead;Leadership;Malignant neoplasm of pancreas;Malnutrition;Manuscripts;Medical Research;National Cancer Institute;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;novel;Observational Study;Ohio;organizational structure;Pancreas;participant enrollment;Patients;Positioning Attribute;predictive marker;Process;Progress Reports;Protocols documentation;Publications;repository;Research;Research Infrastructure;Research Personnel;response;Services;Tissues;Universities;working group

PROJECT_TITLE: The Ohio State University Chronic Pancreatitis Diabetes Pancreas Cancer (CPDPC) Clinical Center


NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Diabetes;Digestive Diseases;Pain Research;Pancreatic Cancer;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Type 2 diabetes, chronic pancreatitis, and pancreatic cancer are common and inter-related diseases that require better approaches to diagnosis and treatment. The Mayo Clinic team is an active participant in multiple CPDPC initiatives, with recruitment into the PROCEED and NOD cohorts, plus the DETECT study. By gaining new knowledge through our contributions, the CPDPC will lead to clinical advances in these pancreas diseases.

PI_NAMEs: VEGE, SANTHI SWAROOP  (contact)

PROJECT_TERMS: Abdominal Pain;acute pancreatitis;Admission activity;Ancillary Study;Awareness;Biological;Biological Markers;Biometry;chronic pancreatitis;Clinic;Clinic Activity;Clinical;clinical phenotype;clinical practice;Clinical Research;cohort;Communities;Consult;design;Diabetes Mellitus;Diagnosis;diagnostic tool;Discipline;Disease;Early Diagnosis;Enrollment;Environment;Epidemiology;epidemiology study;Evaluation;Exocrine pancreas;experience;Goals;Heterogeneity;improved;Incidence;Infrastructure;Institution;Internet;Islets of Langerhans;Knowledge;Laboratories;Lead;Leadership;Life Expectancy;Link;Longitudinal cohort;Longitudinal cohort study;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Medical;Modification;Morbidity - disease rate;mortality;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;Outpatients;Pain;Pain management;Pancreas;Pancreatic Diseases;Pancreatitis;Participant;Patients;Productivity;prospective;Protocols documentation;recruit;Research;Research Infrastructure;Research Personnel;Research Support;Role;Salivary;Sample Size;Solid;stem;Techniques;Training;Validation;working group

PROJECT_TITLE: The Exocrine and Endocrine Pancreas in Type 2 Diabetes, Pancreatitis and Cancer


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Gene Therapy;Genetics;Human Genome;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: PROJECT NARRATIVE Mutations in any gene important for normal immune function can lead to a variety of manifestations of primary immunodeficiency (PID), yet our ability to diagnose and cure these mutations is limited. Beyond sequencing, we do not have a way to functionally discern a PID patient's causative mutation from the thousands of benign natural sequence variants. This work will utilize advanced novel CRISPR gene editing techniques to recreate and directly test the influences of individual variants in primary human cells in order to provide a mechanistic understanding of PID-associated mutations, new diagnostic tools, and novel strategies for non-viral gene correction therapy to benefit patients with genetic diseases of the immune system.

PI_NAMEs: NGUYEN, DAVID-HUY NHU (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Affect;Alleles;Animal Model;antagonist;Autologous;base;Basic Science;Benign;Biology;career;career development;Catalogs;causal variant;cell bank;Cell Death Induction;cell growth;Cell Line;Cell Therapy;Cell Transplantation;cell type;Cells;Chemicals;Chromosome Mapping;Clinical;clinical care;clinical sequencing;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;Complement;Complementary DNA;congenital immunodeficiency;Counseling;CRISPR/Cas technology;CTLA4 gene;cytotoxic;Databases;Development;Diagnosis;Diagnostic;diagnostic platform;diagnostic tool;Disease;disease-causing mutation;DNA;DNA Modification Process;DNA Repair;DNA Structure;Doctor of Philosophy;Dose;Drug Delivery Systems;Engineering;Environment;exome sequencing;Faculty;fighting;functional genomics;functional outcomes;Funding;gene correction;gene editing technology;Gene Expression;gene therapy;gene-editing approach;Genes;Genetic;Genetic Code;Genetic Diseases;Genetic Screening;genetic variant;Genome engineering;Genomics;Goals;Hematopoietic stem cells;Heterozygote;Homo;Human;Hybrids;IL2RA gene;IL2RG gene;Immune;immune function;Immune response;Immune system;Immune System Diseases;immunodeficiency;Immunology;improved;Individual;Infection;innovation;Instruction;JAK3 gene;Knock-in;Knowledge;large datasets;Learning;lectures;Libraries;Link;Medical;member;Mentors;Methods;Modeling;Molecular Diagnosis;Mutate;Mutation;Mutation Analysis;mutation correction;mutation screening;next generation sequencing;novel;novel diagnostics;novel strategies;novel therapeutics;nuclease;Outcome;Pathologic;Pathology;Patients;Physicians;Population;pre-clinical;preclinical development;Prognosis;Proteins;prototype;receptor;Reporter;Reporter Genes;Research;Research Personnel;response;Scientist;Severe Combined Immunodeficiency;Signal Transduction;Site;skills;small molecule;Sorting;stem cell biology;stem cell therapy;Surface;System;T-Lymphocyte;Techniques;Technology;Testing;therapeutic genome editing;TNFSF5 gene;Toxic effect;Training;Transformed Cell Line;Translational Research;transplantation therapy;Variant;Work

PROJECT_TITLE: CRISPR Editing of Primary Human Cells to Model and Correct Primary Immunodeficiency Mutations

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: EAST LANSING

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Development of effective therapies for obesity have been hindered by our limited understanding of the mechanisms regulating food ingestion and weight. This fellowship proposal tests how central neurotensin circuitry may be leveraged to reduce feeding and increase physical activity so as to support weight loss. Via this research the applicant will learn state-of-the art techniques to reveal the neural mechanisms regulating energy balance, which he can leverage throughout his career to understand the cause and treatment of obesity and other neurological diseases.

PI_NAMEs: RAMIREZ-VIRELLA, JARIEL YAMIL (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Agonist;antagonist;arm;Behavior;beta-arrestin;Body Weight;Body Weight decreased;Brain;career;combat;Coupled;Data;Development;Disease;dopaminergic neuron;drinking;Eating;effective therapy;energy balance;Energy Metabolism;feeding;Feeding behaviors;Fellowship;Food;food consumption;Future;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;Ingestion;insight;Lateral Hypothalamic Area;Learning;Ligand Binding;Measures;Mediating;Motor Activity;mouse model;Mus;natural hypothermia;Nervous System Disorder;neural;neuromechanism;Neurons;Neuropeptides;Neurotensin;Neurotensin Receptors;Obese Mice;Obesity;obesity treatment;optogenetics;Outcome;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physical activity;Population;Psychological reinforcement;receptor;Receptor Signaling;reduced food intake;Research;Resolution;restraint;Rewards;Rodent;Role;Signal Pathway;Signal Transduction;Site;Source;Stress;System;Techniques;Testing;therapy development;Ventral Tegmental Area;Water consumption;Weight;Weight Gain;Work

PROJECT_TITLE: Role of Central Neurotensin Signaling in the Ventral Tegmental Area for Ingestive Behavior and Body Weight

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-B]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Current cholesterol treatment guideline put atherosclerotic cardiovascular disease (ASCVD) risk assessment at the center of decision-making for initiating and dosing of lipid-lowering therapies; however, there remain limitations and controversies regarding how efficiently this guideline directs medication to those who will receive a large absolute ASCVD risk reduction benefit. Our study will draw on large, contemporary, and racial/ethnically diverse data sources to develop more refined ASCVD risk assessment approaches, help direct treatment to ethnic subgroups and groups with a high burden of adverse SDOH who have a high ASCVD risk, and ultimately, improve cardiovascular outcomes and narrow cardiovascular health inequities.

PI_NAMEs: AN, JAEJIN ;ZHANG, YIYI  (contact)

PROGRAM_OFFICER_NAME: WOLZ, MICHAEL

PROJECT_TERMS: Address;Adult;Algorithms;American;American Heart Association;Asian;Asian population;Atherosclerosis;California;Cardiology;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Cholesterol;Chronic Kidney Failure;Classification;Clinical;cohort;college;cost effective;Country;Data;Data Sources;Decision Making;Development;Discrimination;Dose;Dyslipidemias;East Asian;Economics;Electronic Health Record;enhancing factor;Epidemiology;Equation;Equilibrium;ethnic diversity;ethnic minority;Ethnic Origin;Ethnic Population;European;Event;ezetimibe;Future;Goals;Guidelines;Health;health disparity;health equity;health inequalities;Health Insurance;Heart failure;high risk;Hispanic;Hispanic Populations;improved;Individual;Inequity;inhibitor;Lipids;Literature;Mexican;Minority Groups;National Health and Nutrition Examination Survey;Outcome;Patients;Performance;Persons;Pharmaceutical Preparations;Population;predictive tools;Primary Prevention;Puerto Rican;Race;racial diversity;racial minority;Recommendation;Recording of previous events;Recurrence;Resources;Risk;Risk Assessment;Risk Estimate;Risk Factors;risk prediction;Risk Reduction;Secondary Prevention;sex;social;social health determinants;South Asian;Subgroup;Treatment Cost;treatment guidelines;Woman

PROJECT_TITLE: Optimize Risk Assessment for Incident and Recurrent Atherosclerotic Cardiovascular Disease

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Telehealth

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project narrative In sub-Saharan Africa (SSA), where need and resource constraint are highest, sub-optimal antiretroviral treatment (ART) retention threatens to derail global HIV epidemic control efforts. Through a quasi-experimental, pre-post designed test of an mHealth innovation and subsequent scale-up in two, high-volume, public ART clinics with over 35,000 ART clients in Malawi, we aim to demonstrate that interactive, two-way texting (2WT) can increase ART retention in a routine setting while providing distinct advantages in terms of data quality, costs, and reduced healthcare worker burden over routine retention efforts. User-centered assessment of successful 2WT integration into the existing electronic medical records system facilitates transfer from research to routine practice, enabling scale-up of this mHealth intervention to improve ART retention across Malawi and SSA.

PI_NAMEs: O'MALLEY, GABRIELLE  (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Address;Adherence;Adoption;Africa South of the Sahara;antiretroviral therapy;Back;Caring;Client;Clinic;cohort;Communication;comparison intervention;cost;cost effective;cost estimate;Cost Savings;Coupled;Data;data quality;design;Drowning;Effectiveness;electronic medical record system;Eligibility Determination;Enrollment;epidemic response;Fatal Outcome;follow-up;Funding;Health;Health Personnel;Healthcare;Healthcare Systems;HIV;HIV Infections;Home visitation;Human;Hybrids;improved;improved outcome;Individual;innovation;International;Intervention;Maintenance;Malawi;Methods;mHealth;mhealth interventions;Motivation;novel;patient retention;Patients;Persons;point of care;Policies;programs;prospective;Provider;Quasi-experiment;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;research to practice;Resources;response;Retrospective cohort;routine care;routine practice;scale up;Schedule;Services;standard care;Stretching;success;System;Technology;Telephone;Testing;Text;therapy design;therapy outcome;Time;Training and Education;Translating;Trust;two way texting;United States National Institutes of Health;Universities;usability;Viral;Viral Load result;Visit;visit adherence;Washington;Workload

PROJECT_TITLE: Two-way Texting (2wT) to Improve Patient Retention While Reducing the Healthcare Workload in High-Burden Public HIV Clinics in Malawi


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the multifunctional RNA-binding protein EWSR1 is associated with the neurodegenerative disease amyotrophic lateral sclerosis (Lou Gehrig’s Disease) as well as rare pediatric sarcomas (Ewing sarcoma). EWSR1 contains an intrinsically disordered, low complexity region implicated in its pathological functions. This project is relevant to NIH’s mission because defining the mechanistic and structural details of EWSR1 functions is the first step toward development of effective, targeted therapies for these diseases.

PI_NAMEs: LIBICH, DAVID STEVEN (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Affinity;Amino Acid Sequence;Amino Acids;Amyotrophic Lateral Sclerosis;analytical ultracentrifugation;Automobile Driving;Behavior;Binding;Biochemical;Biological;Biological Assay;Biological Process;Biology;biophysical techniques;C-terminal;Cell model;Cell Physiology;Cellular Assay;Charge;Chemicals;Childhood Leukemia;childhood sarcoma;Chromosomal translocation;Code;Complex;Coupled;Detection;Development;Diffusion;Disease;DNA;DNA Binding;DNA Binding Domain;DNA Repair;EMSA;Environment;ETS Domain;Event;Ewings sarcoma;EWS-FLI1 fusion protein;Exhibits;experimental study;Family;FLI1 gene;FLI1 Transcription Factor;Fluorescence Recovery After Photobleaching;Frontotemporal Dementia;Gene Expression;Genetic Transcription;Goals;Health;Human;in vivo;Investigation;Label;Link;link protein;Liquid substance;Location;macromolecular assembly;Macromolecular Complexes;Malignant Childhood Neoplasm;Measurement;member;Messenger RNA;Methods;MicroRNAs;Microsatellite Repeats;Microscopy;Mission;Molecular;Molecular Conformation;Monitor;mutant;Mutation;N-terminal;Nature;Nerve Degeneration;Neurodegenerative Disorders;neuron development;Neuropathy;NMR Spectroscopy;Nucleic Acids;Nucleoproteins;Oncogenic;Pathogenicity;Pathologic;Phase;Physical condensation;Process;Property;Protein Dynamics;protein transport;Proteins;Public Health;recruit;Relaxation;reproductive development;Research;Resolution;RNA;RNA Processing;RNA Recognition Motif;RNA Splicing;RNA-Binding Protein EWS;RNA-Binding Proteins;Role;scaffold;self assembly;Signal Transduction;Specificity;stoichiometry;Structure;TAF15 gene;targeted treatment;Technology;therapeutic target;Titrations;tool;tumorigenesis;United States National Institutes of Health;Untranslated RNA;Work

PROJECT_TITLE: An Integrated Biochemical and Structural Approach to Delineating the Biology of EWSR1

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative  In order to combat infections and reduce antimicrobial resistance, it is essential to detect and characterize bacterial/fungal susceptibility to antimicrobials in the early stages of infections to reduce the inappropriate use of antimicrobials and the rate of death. A stimulated Raman scattering imaging - wide-field fluorescence in situ hybridization system will be developed to enable single cell level antimicrobial susceptibility and identity test within 2 hours from fresh sample to final report.

PI_NAMEs: CHENG, JI-XIN  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Address;Agar;anti-microbial drug;Anti-microbial susceptibility;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;bacterial resistance;Biological Assay;Cell Cycle;Cells;Cellular Metabolic Process;Chemicals;Clinic;Clinical;clinical diagnosis;clinical encounter;Color;combat;communicable disease diagnosis;Communicable Diseases;Complex;Death Rate;design;DNA Microarray Chip;drug discovery;Environment;experience;Fiber;Fluorescent in Situ Hybridization;fungus;Glucose;Growth;gut bacteria;gut microbiome;Hour;Image;In Situ;In Situ Hybridization;Infection;innovation;Knowledge;Lasers;Liquid substance;Measurement;Measures;Meningitis;Metabolic;metabolic imaging;Metabolism;Methods;microbial;Microbiology;Microscope;Molecular;Organism;pathogen;Phenotype;Pneumonia;Polymerase Chain Reaction;Predisposition;Protocols documentation;Public Health;Publishing;Reporting;Research;Resistance;Robotics;Sampling;Scientist;Sepsis;Signal Transduction;Specimen;Specimen Handling;Speed;success;System;Technology;Test Result;Testing;Translating;Urinary tract infection;Urologic Diseases;vibration;Work

PROJECT_TITLE: Rapid AST through Metabolic Imaging at Single Cell Level

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease;Precision Medicine;Prevention

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: The utility of MRI-measures of the systemic metabolic state (the metabo-phenotype), hepatic perfusion and clearance function (gadoxetate clearance) and spleen stiffness measurements, alone and in combination with each other as well as other parameters to predict hepatic decompensation in NASH with cirrhosis will be tested.

PI_NAMEs: SANYAL, ARUN J (contact);SIDDIQUI, MOHAMMAD S

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Adipose tissue;Ascites;attributable mortality;Biological Markers;Biology;care delivery;Cessation of life;Child;Cirrhosis;Clinic;Clinical;clinical care;clinical development;clinical imaging;Collaborations;Compensation;Consensus;Data;Data Set;Development;Disease;drug development;elastography;Emerging Technologies;Encephalopathies;Endoscopy;Etiology;Event;Exposure to;Extrahepatic;Fasting;Fatty acid glycerol esters;Fibrosis;Glycosylated hemoglobin A;Goals;health care delivery;hemodynamics;Hemorrhage;Hepatic;Image;improved;individual patient;Industry;Infiltration;innovation;insight;instrument;Insulin;Intervention;Knowledge;Life;Liver;liver function;liver imaging;liver stiffness;liver transplantation;Longitudinal cohort study;Machine Learning;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;Metabolic;Metabolic dysfunction;Methods;Minority;Modeling;Monitor;mortality;mortality risk;Muscle;nature center;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Outcome;outcome prediction;Patient Care;patient population;Patients;Perfusion;Phenotype;Population;Portal Hypertension;prevent;Prevention;Probability;prognostic;prognostic value;Protocols documentation;Publishing;Regression Analysis;Reproducibility;Research;Research Personnel;Risk;routine practice;Scanning;Science;Spleen;Statistical Models;Technology;Testing;Therapeutic;therapeutic development;therapeutically effective;Time;tool;Toxic effect;Training;Translating;uptake;Variant;Varicosity;Venous Pressure level;Visceral;Visceral fat

PROJECT_TITLE: Predicting outcomes in nonalcoholic steatohepatitis with advanced fibrosis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative The successful completion of this project will lead development of mouse model of glaucoma to aid insights into molecular pathways that cause trabecular meshwork dysfunction, elevation of intraocular pressure and neurodegeneration in glaucoma, a leading cause of irreversible vision loss. Furthermore, successful completion of this project will provide mouse model to develop novel treatment strategies for glaucoma.

PI_NAMEs: ZODE, GULAB  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Adenoviruses;Affect;Antibodies;Aqueous Humor;Axon;Biochemical;Blindness;Brain;Chronic;cis acting element;Development;Docking;DsRed;Engineering;Exhibits;Functional disorder;functional loss;Gene Mutation;Gene Silencing;Generations;Genes;Genetic;Genetic Transcription;genomic locus;Glaucoma;Goals;Human;immunogenicity;inducible Cre;Inflammation;Injections;innovation;insight;Integrase;interest;intravitreal injection;Investigation;Knock-in;Lead;Light;Mediating;Methylation;Modeling;modifiable risk;Molecular;molecular sieving;Morphology;mouse development;mouse model;Mus;mutant;Mutation;myocilin;nerve damage;Nerve Degeneration;Neurotransmitters;novel;Ocular Hypertension;Optic Nerve;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Persons;Phenotype;Physiologic Intraocular Pressure;Primary Open Angle Glaucoma;promoter;Proteins;Resistance;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;Risk Factors;Route;Serine;Site;Stains;Structure;Technology;Trabecular meshwork structure;Transgenes;Transgenic Mice;Transmission Electron Microscopy;treatment strategy;Viral;Viral Packaging;Viral Vector;Virus Replication;Visual;Visual evoked cortical potential;Western Blotting

PROJECT_TITLE: Development and characterization of an inducible model for myocilin POAG

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: RELEVANCE: Pancreatic cancer has the worst prognosis of any common cancer, and is the 3rd leading cause of cancer deaths in the United States. Here we will explore how targeting two important pathways in pancreatic cancer can be exploited therapeutically by limiting tumor proliferation and inducing an immune response. These studies are specifically directed at improving the outcome of pancreatic cancer.

PI_NAMEs: KNUDSEN, ERIK ;WITKIEWICZ, AGNIESZKA  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Antigen Presentation;Automobile Driving;Biochemical;Cancer Etiology;CDK4 gene;Cell Cycle;Cell division;Cells;Cessation of life;Clinical;Clinical Trials;Collection;Combined Modality Therapy;Complement;Complex;Correlative Study;Coupled;Cytostatics;Data;Disease;Effectiveness;Elements;Epigenetic Process;epigenome;Gene Expression;Gene Expression Regulation;Genes;Genetic;Growth;Immune response;Immune system;Immunocompetent;immunoengineering;Immunologics;Immunotherapy;improved outcome;inhibitor;Interferons;Intervention;KRAS2 gene;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;MEK inhibition;MEKs;Modeling;neoplastic cell;novel strategies;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;Population;Pre-Clinical Model;Prognosis;programs;Proliferating;Publishing;Regulation;Regulatory Element;Resistance;response;retinoblastoma tumor suppressor;Specimen;Survival Rate;targeted treatment;Therapeutic;therapy development;therapy resistant;Tissues;treatment response;tumor;Tumor Biology;tumor microenvironment;tumorigenesis;tumorigenic;United States;Work

PROJECT_TITLE: Impact of RB activation on the pancreatic cancer epigenome and tumor microenvironment

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Eosinophilic allergic mucin chronic rhinosinusitis (EMRS) is a debilitating chronic rhinosinusitis subtype that disproportionally burdens sociodemographic minorities, who often present with more advanced disease, have worse post-surgical treatment outcomes, and higher rates of morbidity such as facial bone deformities and vision changes. The etiology behind the disparities in EMRS presentation and outcomes are not explained by clinical disease severity alone, leaving important questions about how to reduce disease burden unanswered until researchers understand the multiple factors that influence EMRS treatment outcomes. The results of this research will determine the important multidimensional factors that predict EMRS treatment outcomes and will help inform clinical practice recommendations and interventions to improve care and reduce disparities for EMRS patients.

PI_NAMEs: LEVINE, CORINNA GEHRETT (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Acculturation;Address;advanced disease;Affect;Aftercare;Allergic;Analysis of Variance;Anosmia;Biological;black patient;Black race;burden of illness;career;Caring;chronic rhinosinusitis;Clinical;clinical practice;Clinical Treatment;cohort;Communication;Communities;community-level factor;Computer Models;cytokine;Data;Deformity;Development;Dimensions;Disease;disorder subtype;Disparity;disparity reduction;Early treatment;education resources;Educational Intervention;Environmental Exposure;Environmental Risk Factor;Ethnic Origin;Etiology;Face;face bone structure;Feedback;Florida;Future;Glean;Goals;Headache;health care availability;health determinants;Health Services Accessibility;high risk population;Hispanic;Home;Humidity;IgE;Impairment;improve minority health;improved;improved outcome;Individual;Infection;Inflammatory;Inflammatory Response;Interdisciplinary Study;Intervention;Interview;Knowledge;Language;Lead;Life;Longitudinal cohort study;low socioeconomic status;Lung;machine learning model;Measures;Mediating;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;microbiome;Minority;Mission;Modeling;Molds;Morbidity - disease rate;Mucins;Mucous body substance;National Institute on Minority Health and Health Disparities;Neighborhoods;Operative Surgical Procedures;Outcome;outcome disparities;Outcome Measure;Paranasal Sinus Diseases;Pathway interactions;patient oriented;patient-clinician communication;Patients;Physical environment;Polyps;Population;Population Heterogeneity;Positioning Attribute;Predictive Factor;prevent;prospective;Prospective cohort;Provider;Qualitative Research;Race;random forest;Recommendation;Recurrence;Reduce health disparities;Reporting;Research;Research Methodology;Research Personnel;Research Training;response;Sampling;Science;Scientist;Severity of illness;Sinus;social cohesion;social culture;social stress;sociodemographics;Socioeconomic Status;Structure;Symptoms;Testing;therapy development;Thick;Time;tool;Training;Training Programs;treatment center;Treatment outcome;United States;Vision

PROJECT_TITLE: Eosinophilic Mucin Chronic Rhinosinusitis: Determining the multi-level factors that mediate disease and disparities


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular

ORG_CITY: BOSTON

PHR: PROJECT NARRATIVE:  Trimethylamine N-oxide (TMAO) is a common dietary derived metabolite that has emerged as a central driver of cardiovascular disease. But efforts to leverage this pathway therapeutically have been impeded by a lack of a clear mechanistic understanding of TMAO action. Therefore, we propose to define how TMAO causes atherosclerosis by defining TMAO’s direct effects on its only known receptor and elucidating the TMAO atherogenic stress response.

PI_NAMEs: ADAMSON, STUART ST JOHN (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acute;Amines;Animal Model;Aorta;Aortitis;Apolipoprotein E;arm;ATF6 gene;Atherosclerosis;Binding;biological adaptation to stress;Blood Glucose;Boston;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cause of Death;Cell Death;Cellular Stress;Cessation of life;Cholesterol;Chronic;Clinical;Communication;Complex;Core Facility;Data;Development;Diet;dietary;Dietary Supplementation;Disease;Endoplasmic Reticulum;Ensure;Environment;Equipment;Event;experimental study;feeding;Floods;Functional disorder;Gel;gel electrophoresis;Gene Expression;Goals;Human;Immunofluorescence Immunologic;improved;In Vitro;Individual;Inflammation;Inflammatory;insight;Institution;kinase inhibitor;Mediating;Metabolic;Mind;Molecular;Molecular Conformation;Monitor;mortality;Mus;novel;Oxides;Pathway interactions;Pediatric Hospitals;Phosphorylation;Phosphotransferases;Physiological;Plasma;premature;prevent;Productivity;Proteins;Public Health;Public Health Schools;Publications;receptor;Reporting;Research;Research Personnel;Resources;response;Risk Factors;Role;Signal Transduction;Stress;Testing;Therapeutic;tool;Training;vascular inflammation;Western Blotting;Work;World Health Organization

PROJECT_TITLE: Determining the Involvement of PERK in TMAO Induced Atherosclerosis


NIH_SPENDING_CATS: Clinical Research;Networking and Information Technology R&D (NITRD);Nutrition;Patient Safety

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative The Data Coordinating Center (DCC) will enable the dietary biomarker development centers (DBDCs) Consortium to bring together multidisciplinary experts to enhance the field of dietary biomarker development by providing administrative, biostatistics, data management, self-service analytics, interactive reporting, and data analysis support to identify biomarkers of dietary intake. Specifically, the DCC will 1) provide a robust administrative management structure that enhances communication and improves the DBDC’s productivity and quality, 2) provide data harmonization, transfers, integration, processing, and management, 3) develop self-service analytics to generate data summaries, dynamic/interactive reporting, and analysis support for integrated biomarker validation, and 4) communicate and disseminate knowledge within and beyond the Consortium. Our team’s nationally recognized expertise in data management, harmonization, and coordination of large networks, and our experience in biomarker research uniquely positions the DCRI to provide all of the services and support required by the DBDC’s Consortium.

PI_NAMEs: CHAKRABORTY, HRISHIKESH  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Agreement;Ancillary Study;Biological Markers;biomarker development;biomarker identification;Biomarker of Dietary Intake;biomarker performance;biomarker validation;Biometry;catalyst;Certification;Clinical Research;Clinical Trials Data Monitoring Committees;cloud storage;Collaborations;Common Core;Communication;Communities;Complement;Confidentiality of Patient Information;Consensus;Consent Forms;Creativeness;Data;Data Aggregation;Data Analyses;data anonymization;Data Collection;Data Coordinating Center;data dissemination;data exchange;Data Files;data harmonization;data integration;data management;data modeling;data quality;data repository;Data Set;data sharing;data submission;Development;dietary;Dietary Administration;dietary constituent;Dietary intake;dietary requirement;Documentation;electronic data capture system;Enrollment;Ensure;evidence base;experience;Food;Goals;Guidelines;Health Insurance Portability and Accountability Act;improved;Individual;Infrastructure;innovation;Institutional Review Boards;Knowledge;Leadership;Link;Manuals;Manuscripts;meeting reports;meetings;member;Metabolic;Metabolism;Methodology;Methods;microbial;Monitor;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Office of Administrative Management;Online Systems;operation;Outcome;Performance;Positioning Attribute;Preparation;Privacy;Productivity;Protocols documentation;Publications;recruit;Reporting;repository;Research;Research Institute;Research Project Grants;Resources;Risk;Safety;Science;Secure;Services;Site;Standardization;Statistical Data Interpretation;Structure;Teleconferences;timeline;tool;Training;transmission process;United States Department of Agriculture;user-friendly;Vision;Visual;webinar;Work;working group;Writing

PROJECT_TITLE: Biomarkers of Dietary Intake and Exposure Data Coordinating Center


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE Brain functions arise from complex networks of many different types of cells connected in neural circuits. The goal of this UM1 project is to map the identities and compositions of the many different kinds of cells in various regions of the human brain. Determining the molecular properties and locations of cells from a diverse population of human brain samples will aid in our understanding of normal human brain functions and the underlying mechanisms of a variety of human neurological and neuropsychiatric diseases.

PI_NAMEs: BEHRENS, M MARGARITA;ECKER, JOSEPH R (contact);LI, DAOFENG ;REN, BING ;XU, XIANGMIN

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;Anatomy;Atlases;Autopsy;Behavioral;Biological Assay;Brain;brain cell;BRAIN initiative;Brain Mapping;Brain Pathology;Brain region;brain tissue;Categories;cell type;Cells;Censuses;Chromatin;Communities;Complex;cost effective;Cytosine;Data;Data Analyses;data integration;data management;data portal;Data Set;Dependovirus;DNA;DNA analysis;DNA Methylation;Enhancers;epigenome;epigenomics;experimental study;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;genetic analysis;Genetic Markers;Genetic Transcription;genetic variant;Genome;Genomics;Goals;Heterochromatin;histone modification;Histones;Human;Image;imaging approach;improved;Individual;invention;Joints;large scale data;Location;Maps;Mediating;Methods;Molecular;Morphology;multidisciplinary;multimodality;multiple omics;Mus;Nervous System Disorder;neural circuit;Neuroanatomy;neurochemistry;Neuroglia;Neurons;neuropsychiatric disorder;Nucleic Acid Regulatory Sequences;Physiological;Population Heterogeneity;postmitotic;Production;programs;promoter;Property;Records;Regulation;Regulatory Element;Resolution;RNA;Sampling;Series;single cell analysis;single nucleus RNA-sequencing;Small Nuclear RNA;Spatial Distribution;Specimen;Structure;success;Surveys;Technology;Testing;Tissue Sample;Tissues;tool;Transcript;transcriptome;transcriptomics;Untranslated RNA;Validation;Visualization

PROJECT_TITLE: Center for Multiomic Human Brain Cell Atlas


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Prostate cancer (PCa) is a significant cause of morbidity and mortality in men. Currently, there is a significant unmet need for identifying men at initial diagnosis who will ultimately progress to metastatic, lethal disease. This project investigates the combination of clinically translatable imaging technologies: diffusion basis spectral imaging (DBSI) MRI and matrix assisted laser desorption ionization (MALDI) histologic molecular imaging to identify “imageable” biomarkers associated with poor outcomes in men being evaluated for prostate cancer at initial diagnosis. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page

PI_NAMEs: IPPOLITO, JOSEPH EDWARD (contact);KIM, ERIC H

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: 3D Print;Acceleration;Affect;American;Artificial Intelligence;artificial intelligence algorithm;Benign;biobank;Biochemical;Biological Assay;Biological Markers;Biopsy;Blood Banks;Cancer Etiology;Cessation of life;clinic ready;Clinical;clinical risk;clinical translation;cohort;Collagen;curative treatments;Data;Diagnosis;Diet;Diffusion;Disease;effective therapy;Enrollment;experience;experimental study;extracellular;Extracellular Matrix;Fucose;Genomic approach;genomic platform;genomic signature;genomic tools;Genomics;Goals;Histologic;histological image;histological specimens;Histology;Image;imaging biomarker;Imaging Device;imaging modality;Imaging technology;in vivo;in vivo imaging;Inflammation;Inflammatory;Information Systems;insight;Institution;liquid biopsy;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;mass spectrometric imaging;Measures;men;Metabolic;Metabolism;Methods;Modeling;Molds;Molecular;molecular imaging;molecular marker;Morbidity - disease rate;mortality;multidisciplinary;Neoplasm Metastasis;Nomograms;non-invasive imaging;novel;Organ;Outcome;outcome prediction;Pathology;patient stratification;patient subsets;Patient-Focused Outcomes;Patients;Polysaccharides;Prognosis;prognostic;prognostic model;prospective;Prospective cohort;Prostate;Prostate Adenocarcinoma;Prostatectomy;Prostatic Neoplasms;Provider;Race;racial disparity;Radiation therapy;Radical Prostatectomy;radiomics;Recurrence;Recurrent disease;Reporting;risk prediction model;risk stratification;Sensitivity and Specificity;Serum;Severities;spectrograph;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stromal Cells;Stromal Hyperplasia;structural imaging;survival outcome;Testing;Time;Tissues;tool;Training;tumor;tumor microenvironment;Variant;Visualization;water diffusion

PROJECT_TITLE: Identifying lethal prostate cancer at diagnosis with advanced proteoglycomic, radiomic, and genomic approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-L(59)R]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Over the past 40 years little progress has been made in the treatment of pancreatic cancer, the third leading cause of cancer-related deaths in the United States. This proposal characterizes the contribution of a protein that regulates gene expression to the biology pancreatic cancer. The insight gained from these studies will real novel mechanisms contributing to this highly chemoresistant disease and may provide new avenues for therapeutic intervention.

PI_NAMEs: LISS, ANDREW  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: 3-Dimensional;Acinar Cell;Acute;Architecture;Biological;Biology;Cancer Etiology;cancer invasiveness;cancer subtypes;Cell Culture Techniques;Cell Line;cell type;Cells;Cessation of life;Chemoresistance;chemotherapy;Chromatin;Chromatin Loop;Chromosomes;Cleavage Under Targets and Release Using Nuclease;Co-Immunoprecipitations;cohesin;cohesion;Collection;CRISPR/Cas technology;CSPG6 gene;Data;defined contribution;Development;digital;Disease Resistance;DNA;Epigenetic Process;epigenetic regulation;Evolution;experimental study;Expression Profiling;Gene Expression;Genes;Genetic Screening;Genetic Transcription;Genetically Engineered Mouse;Growth and Development function;histone demethylase;Human Cell Line;human RNA sequencing;in vivo;innovation;insight;Investigation;KRAS2 gene;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mediating;Mediator;Mesenchymal;Modeling;molecular subtypes;Molecular Target;mouse model;Mutation;nano-string;novel;novel therapeutic intervention;novel therapeutics;Outcome;Pancreas;pancreas development;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;patient response;patient subsets;Patient-Focused Outcomes;Patients;pre-clinical;progenitor;programs;Proteins;Publishing;recruit;Regimen;Research;Resolution;response;Role;single-cell RNA sequencing;Specimen;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;transcriptome sequencing;transcriptomics;tumor;tumor growth;tumor initiation;tumor microenvironment;tumor xenograft;tumor-immune system interactions;Tumor-infiltrating immune cells;tumorigenesis;United States;virtual;Work

PROJECT_TITLE: Epigenetic regulation of pancreatic cancer subtype identity and tumorigenesis by PHF2

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

PHR: PROJECT NARRATIVE New targeted anticancer agents are urgently needed for the treatment of Epstein-Barr Virus (EBV)-positive lymphomas, chief among them Diffuse Large B Cell Lymphoma (DLBCL), the most common lymphoma worldwide. VK-2019, a potent EBNA1 inhibitor, is selectively toxic to EBV-infected tumor cells, but not to EBV- negative cells in vitro and in vivo. A phase I clinical study with patients with advanced EBV-positive nasopharyngeal carcinoma demonstrated that VK-2019 exhibits a favorable pharmacokinetics and safety profile. In this Phase Ib study, we propose to confirm the safety and tolerability of the drug, obtain a preliminary signal of anti-tumor efficacy, study the effects of VK-2019 treatment on EBV and cellular gene expression and on the tumor microenvironment, in EBV-positive DLBCL patients.

PI_NAMEs: LIEBERMAN, PAUL M. (contact);MESSICK, TROY E;PORCU, PIERLUIGI

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Adverse event;Affect;Aftercare;Age;Antineoplastic Agents;Biological;Biological Availability;Biological Markers;Biopsy;cancer stem cell;carcinogenesis;Cell Communication;Cell Cycle Arrest;cell growth;Cell Maintenance;Cell Proliferation;Cell Survival;Cells;Cessation of life;chemotherapy;Clinical;clinical candidate;Clinical Research;Clinical Trials;Data;Disease;DNA Binding;Dose;Dose Limiting;Drug Kinetics;Ecosystem;Enrollment;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Lymphoma;Epstein-Barr Virus-Related Malignant Neoplasm;Exhibits;first-in-human;Funding;Gene Expression;Genes;genetic regulatory protein;Grant;Human;Human Herpesvirus 4;human study;Image;Immune Evasion;immune function;Immune response;Immunity;Immunofluorescence Immunologic;Immunosuppression;In Vitro;in vivo;Industry;Infection;Inferior;Infrastructure;inhibitor;Investigation;Kimmel Cancer Center at the Thomas Jefferson University;large cell Diffuse non-Hodgkin's lymphoma;Lead;lead optimization;Link;Lymphoid Cell;Lymphoma;Maintenance;Malignant Neoplasms;Measures;Medical;medication safety;Metabolic;Metabolic Pathway;Modality;Modeling;Mus;Myeloid Cells;Nasopharynx Carcinoma;neoplastic cell;novel;novel therapeutic intervention;Oncogenic Viruses;open label;Oral Administration;Orthologous Gene;Pathway Analysis;Pathway interactions;patient population;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phase;phase 1 study;Phase I Clinical Trials;Phase Ib Clinical Trial;Phase II Clinical Trials;Plasma;pre-clinical;preclinical study;prevent;Process;Prognosis;Property;Proteins;Recommendation;Research Personnel;response;RNA;Role;Safety;Serious Adverse Event;Signal Pathway;Signal Transduction;small molecule inhibitor;specific biomarkers;Specimen;Stable Disease;stem cell population;stem cells;Stromal Cells;Testing;The Wistar Institute;Therapeutic;Therapeutic Agents;Toxic effect;Toxicology;transcriptomic profiling;transcriptomics;translational scientist;treatment effect;tumor;tumor growth;tumor microenvironment;tumor-immune system interactions;tumorigenesis;Universities;Viral;Viral Genes;Viral Genome;Viral Load result;Viral Oncogene

PROJECT_TITLE: EBNA1 Inhibitor for Treatment of EBV-positive DLBCL

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Cancer

PHR: PROJECT NARRATIVE The incidence of neoplasia and death resulting from this disease remains a significant public health challenge globally, and it has become increasingly evident that immune-based approaches will have a substantial impact in our understanding of cancer prevention, diagnosis, prognosis, and treatment. Pre-doctoral training provided by the Tumor Immunology Training Program (TITP) is directly pertinent to public health. The continued primary mission of the TITP is to educate, train, and prepare the next generation of talented scientists with the concepts, knowledge, and skills of fundamental and translational tumor immunology, which provides the necessary foundation to develop and advance innovative approaches to human cancer biology and therapy.

PI_NAMEs: ABRAMS, SCOTT I. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Multidisciplinary Approaches to Tumor Immunology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Narrative The current proposal will document the UM Pepper Center’s outstanding environment for training of junior faculty in geriatrics research and for carrying out and supporting research on health problems of older adults. The UM Pepper Center will emphasize its theme by conducting research that will improve understanding of how metabolic factors and inflammation interact with age-related diseases and comorbidities to determine key health outcomes related to mobility and functional status. OAIC Research Education Core (REC) training activities will help OAIC junior faculty participants apply basic findings to clinical investigation, explore mechanisms underlying clinical and epidemiological findings, and translate basic and clinical findings to a broader older adult community. The Pilot and Exploratory Studies Core (PESC) will generate high quality innovative pilot research related to the OAIC theme. The OAIC Biomechanics Core (BC) will assist and train investigators in the conduct of new and expanded research on how metabolic disease and inflammation interact with age-related disease to determine key health outcomes related to mobility and functional status, the biomechanics of aging. The Biomechanics Core will also contribute to the training of geriatricians and other clinicians in the biomechanics relevant to impaired mobility, falls and fall-related injuries, urinary incontinence and prolapse in older people. The OAIC Core Facility for Aged Rodents (CFAR) will develop new varieties of mice that provide insight into the causes and possible treatments of late-life human diseases to help improve clinical care of older people and suggest ways to prevent illness in this population. The OAIC Human Subjects and Assessment Core (HSAC) will provide the infrastructure and ‘know how’ to accelerate development and translation of basic research to prevent, delay, and treat age-related disabilities and diseases relevant to the theme of the OAIC. The HSAC will be a critical resource for junior investigators engaging in clinical aging research, and provide laboratory researchers new to clinical studies the support they need to engage in human work. The OAIC Design, Data and Biostatistics Core (DDBC) will provide methodological and analytical support to OAIC affiliated investigators to conduct effective, successful and scientifically rigorous research studies.

PI_NAMEs: YUNG, RAYMOND L (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Academy;Acceleration;Activities of Daily Living;Address;age related;age-related disease;aged;Aging;aging process;American;Basic Science;Biomechanics;Biostatistics Core;Capsicum;career development;Caring;Chronic Disease;Clinical;Clinical and Translational Science Awards;clinical care;clinical investigation;Clinical Research;Cognition;cognitive function;Communities;comorbidity;Core Facility;Data;design;Development;disability;Disease;education research;Elderly;Elements;Environment;Epidemiology;Faculty;fall injury;falls;functional independence;functional status;Funding;Future;Geriatrics;Geroscience;Goals;Grant;Health;Health Professional;Health Promotion;healthspan;Home;Human;human disease;human subject;improved;improved outcome;Inflammation;Inflammatory;Infrastructure;innovation;insight;Institute of Medicine (U.S.);Institution;interest;investigator training;Knowledge;Laboratories;late life;Leadership;Link;Longevity;Mediator;Medicine;member;Mentorship;Metabolic;Metabolic Diseases;Methodology;Methods;Michigan;Mobility decline;Modeling;mortality;Mus;older adult;Older Population;Outcome;Participant;Physical activity;Physical Function;Pilot Projects;poor health outcome;Population;prevent;programs;Ptosis;Quality of life;Recording of previous events;Reporting;Research;Research Personnel;Research Project Grants;research study;Research Support;Research Training;Resources;Rodent;senior faculty;Strategic Planning;Structure;Technology;Testing;Training;Training Activity;Training Programs;Translating;Translational Research;Translations;United States National Institutes of Health;Universities;Urinary Incontinence;Work

PROJECT_TITLE: Claude D. Pepper Older Americans Independence Centers (OAICs)(P30)


NIH_SPENDING_CATS: Aging

PI_NAMEs: ALEXANDER, NEIL  (contact)

PROJECT_TERMS: age-related disease;Aging;aging related;aging related disease;Alzheimer's Disease;American;Applications Grants;Area;Award;Behavior;Benchmarking;black men;Blood Vessels;Capsicum;Cardiology;career development;Career Mobility;Clinical;clinical center;clinical investigation;Clinical Research;Clinical Sciences;Collaborations;Communicable Diseases;Communities;comorbidity;Data;design;Development Plans;Diabetes Mellitus;Discipline;Disease-Modifying Second-Line Drugs;Drug resistance;ecto-nucleotidase;education research;Elements;Ensure;Epidemiology;Evaluation;Faculty;functional status;Funding;Geriatrics;Gerontology;Goals;Gram-Negative Bacteria;Grant;Health;improved;Inflammation;K-Series Research Career Programs;Leadership;leadership development;lecturer;Life Style;Medicare claim;meetings;Mentors;Mentorship;Metabolic;Metabolic Diseases;Michigan;Monitor;next generation;Non-Insulin-Dependent Diabetes Mellitus;older adult;Outcome;Output;peer;professor;Program Development;programs;Publications;Qualitative Evaluations;recruit;Research;Research Activity;research and development;Research Personnel;Research Project Grants;Research Training;Resources;Rheumatoid Arthritis;Rheumatology;Role;Self Management;Skilled Nursing Facilities;Social Work;Structure;Study Section;symposium;Teacher Professional Development;therapy design;Time;Training;Training Activity;Translating;Translational Research;United States National Institutes of Health;Universities;Variant;Work;Writing

PROJECT_TITLE: Research Education Component