ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Mitochondria provide the fuel for cellular activities, and diseases caused by mutations in their components represent a common inborn error of metabolism in children. Cardiac involvement in these disorders portends poorer outcomes, with a nearly threefold increase in mortality. In this proposal, we propose to study a novel regulatory pathway, involving enhanced influx of calcium into cardiac mitochondria, which may provide a new target for treating heart failure in these devastating diseases.

PI_NAMEs: CHAUDHURI, DIPAYAN  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Address;Adenine;Affect;Animals;Antioxidants;ATP Synthesis Pathway;Binding;Bioenergetics;Biological Assay;Biology;Calcium;Calcium Signaling;calcium uniporter;Carbon;Cardiac;Cardiomyopathies;Child;Childhood;Complex;Cytoprotection;Death Rate;Dependovirus;Dinucleoside Phosphates;Disease;Drosophila genus;Enzymes;Equilibrium;Functional disorder;functional improvement;Heart;Heart failure;heart function;Heart Injuries;heart metabolism;heart preservation;Homeostasis;Human;Impairment;improved;Inborn Errors of Metabolism;Infant;Link;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial cardiomyopathies;Mitochondrial DNA;Mitochondrial Matrix;mitochondrial metabolism;Modeling;mortality;mouse model;Mus;Mutation;N-terminal;NADH;NADH dehydrogenase (ubiquinone);NADP;neonatal mice;Niacinamide;novel;novel therapeutics;Organ;Outcome;Oxidation-Reduction;Oxidative Phosphorylation;Pathologic;Pathologic Processes;Pathology;Pathway interactions;Physiological;Physiology;preservation;Prevalence;prevent;Production;Prognosis;protein degradation;Proteins;Reactive Oxygen Species;Regulation;Regulatory Pathway;Signal Transduction;Testing;Therapeutic;transcription factor;transgene expression;Up-Regulation;uptake;virtual;Work

PROJECT_TITLE: Metabolic Impact and Mechanism of Enhanced Mitochondrial Calcium Uptake in Mitochondrial Cardiomyopathies

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: COLLEGE STATION

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (PROJECT NARRATIVE) The goal of this project is to develop generally-applicable molecular tools for precise tuning of T cell activity and improve therapeutic T cell-based immunotherapy for human disease interventions. We propose new engineering approaches to generate a series synthetic biology tools that can be used as biomedical research tools to benefit immunotherapy against cancer and immunoinflammatory disorders.

PI_NAMEs: ZHOU, YUBIN  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Acceleration;adaptive immunity;anergy;Antigens;Binding;Biomedical Research;C-terminal;Caffeine;Calcineurin;Calcium;Calcium Channel;Calcium Channel Blockers;calmodulin-dependent protein kinase II;CAR T cell therapy;CD19 gene;cell mediated immune response;Cell membrane;Cell Physiology;Cell Therapy;Cellular immunotherapy;Chemicals;chimeric antigen receptor;chimeric antigen receptor T cells;Coupled;cytokine;cytokine release syndrome;Cytoplasmic Granules;Cytosol;Data;design;Dimerization;Disease;Distal;Endoplasmic Reticulum;Engineering;Enzymes;Event;exhaustion;Exhibits;Face;FDA approved;Functional disorder;Genetic;Genetic Transcription;Goals;Hand;Hematologic Neoplasms;human disease;Hyperactivity;immunoengineering;Immunotherapy;improved;In Vitro;in vivo;Inflammatory;innovation;Intervention;Ion Channel;Kinetics;Light;Lymphocyte Activation;Malignant Neoplasms;Modeling;Modification;Molecular;Molecular Conformation;Names;neurotoxicity;novel;nuclear factors of activated T-cells;Nuclear Translocation;optogenetics;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Physiological Processes;Pilot Projects;Process;Production;Protein Dephosphorylation;Proteins;public health relevance;Publications;Receptor Signaling;recruit;Route;Safety;Scheme;Series;side effect;Signal Transduction;small molecule inhibitor;STIM1 gene;synthetic biology;System;T cell therapy;T-Cell Activation;T-Cell Activation Pathway;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;T-Lymphocyte Subsets;Tail;Testing;Therapeutic;Time;tool;Toxic effect;transcription factor;translational potential

PROJECT_TITLE: Synthetic biology toolkit for precise tuning of T cell activity


NIH_SPENDING_CATS: Asthma;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Effects of Indoor Air Pollution;Infectious Diseases;Lung;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Schools represent a source of exposure to respiratory viruses, yet there is little data on factors that influence school respiratory virus exposure. The proposed research is relevant to the part of NIH’s mission to promote healthier environments by identifying factors predicting classroom airborne respiratory virus exposure including testing the efficacy of a high efficiency particulate air (HEPA) cleaner intervention in reducing classroom respiratory virus exposure and infection. We urgently need research to identify practical and evidence-based strategies to create safe indoor school environments for students.

PI_NAMEs: LAI, PEGGY SUE (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Adenoviruses;Adherence;Air;air sampling;Allergens;Asthma;asthma exacerbation;asthmatic;Behavior;built environment;Child;cohort;Coronavirus;COVID-19 outbreak;COVID-19 pandemic;COVID-19 patient;Data;Detection;digital;disease transmission;Disinfectants;Dose;efficacy evaluation;efficacy testing;elementary school;Enterovirus;Environment;environmental intervention;evidence base;Exposure to;Fatigue;Future;Goals;Handwashing;high efficiency particulate air filter;Home;Household;Human;Humidity;Individual;Indoor environment;Infection;Infection Control;Influenza A virus;influenzavirus;Infrastructure;inner city;innovation;Intention;Intervention;Intervention Studies;Intervention Trial;Masks;Measles;Metapneumovirus;meter;Mission;Molecular;Morbillivirus;Mumps virus;Nature;Nose;pandemic disease;pandemic influenza;Parainfluenza;Particulate;Placebo Control;portability;post-COVID-19;Predictive Factor;protective behavior;Public Health;public health intervention;Publishing;Randomized;randomized placebo controlled trial;randomized trial;Randomized, Controlled Trials;recruit;Research;respiratory infection virus;Respiratory syncytial virus;respiratory virus;Rhinovirus;Risk;Rubella virus;Sampling;SARS coronavirus;school environment;school reopening;Schools;screening;secondary analysis;Source;Spanish;Students;Study models;Surface;Surveys;Symptoms;Temperature;Testing;transmission process;United States National Institutes of Health;Vaccines;ventilation;Viral;viral detection;Viral Load result;Viral Respiratory Tract Infection;Virus;Virus Diseases

PROJECT_TITLE: High efficiency particulate air cleaner intervention to reduce respiratory virus exposure in elementary schools

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Breastfeeding, Lactation and Breast Milk;Digestive Diseases;Inflammatory Bowel Disease;Nutrition;Pediatric;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: LAY SUMMARY The immune system must build tolerance to proteins in the intestinal lumen for life-long health and to avoid inflammation against the microbiota or dietary products. This process is regulated by components in breastmilk, yet only 30% of infants globally are exclusively breastfed for the first three months. This grant explores how immune responses are mounted toward dietary products in the absence of maternal milk and if those responses result in inflammation later in life.

PI_NAMEs: KNOOP, KATHRYN A (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Adolescent;Age;Allergic;Antigen-Presenting Cells;Antigens;Biological Assay;Breast Feeding;Cells;Childhood;Coculture Techniques;Colitis;Colon;conditional knockout;Crohn's disease;Curiosities;Data;Dendrites;Diet;dietary;Dietary Practices;Disease;Effector Cell;Environment;Epidermal Growth Factor;Epidermal Growth Factor Receptor;Epigenetic Process;Epithelium;Exclusive Breastfeeding;Food;Food Hypersensitivity;FOXP3 gene;Gastrointestinal tract structure;Goat;Goblet Cells;Grant;Growth Factor Inhibition;gut inflammation;Health;Human;Human Milk;Immune;Immune response;Immune system;In Vitro;in vivo;Incidence;Individual;Infant;Infant formula;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Interleukin-10;Intestinal permeability;Intestines;Kinetics;Lactation;Life;M cell;Macrophage;Maps;Mediating;microbiota;Milk;Modeling;Mothers;Mucosal Immune System;Mucositis;Mus;Neonatal;neonate;Oral;oral tolerance;Outcome;Peripheral;Phase;Phenotype;Population;Predisposition;Prevention;Process;Production;Proteins;Publishing;Recommendation;Regulation;Regulatory T-Lymphocyte;response;Risk;Role;Small Intestines;Solid;System;T cell differentiation;T-Lymphocyte;Testing;Time;transcriptome sequencing;Ulcerative Colitis;Weaning;Work;World Health Organization

PROJECT_TITLE: Immune Outcomes to Neonatal Antigen Delivery in the Intestine

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH The benefit of long-acting therapies that can replace daily pills to people living with HIV is significant. Ultra-long- acting formulations providing steady release over several months of combination antiretroviral drugs can potentially increase accessibility and compliance to HIV treatment regimen and transform the HIV treatment landscape. The overarching goal of this proposal is to develop and evaluate a biodegradable and highly tunable polymeric solid implant that can contribute to curb the HIV epidemic.

PI_NAMEs: BENHABBOUR, SOUMYA RAHIMA (contact);COTTRELL, MACKENZIE

PROGRAM_OFFICER_NAME: PROTOPOPOVA, MARINA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adult;Adverse event;Allergic Reaction;allergic response;Animals;Anti-Retroviral Agents;Anti-retroviral drug resistance;antiretroviral therapy;Behavioral;biodegradable polymer;Characteristics;chemical property;Chronic;chronic infection;Communities;controlled release;cost effective;Data;design;Development;Dose;Drug Delivery Systems;Drug Kinetics;drug release kinetics;Drug resistance;efficacy evaluation;Engineering;Epidemic;Evaluation;Failure;Fatigue;FDA approved;Formulation;Fostering;Goals;Grant;Health Benefit;Health protection;Health Services Accessibility;HIV;HIV Infections;HIV Seropositivity;HIV-1;Implant;implant design;Implantable Infusion Pumps;improved;In Vitro;in vivo;Inbred BALB C Mice;Incidence;Individual;Infection;Injectable;Injections;innovation;Lead;Macaca;Macaca mulatta;Maintenance;manufacture;manufacturing process;Measures;Medical;Modeling;Mus;nanoparticle;nonhuman primate;novel;novel drug combination;novel therapeutics;Oral;Patients;Performance;Persons;Pharmaceutical Preparations;pharmacologic;pharmacometrics;pill;Plasma;Polymers;pre-clinical;pre-exposure prophylaxis;Prevention strategy;Privacy;Process;programs;Property;Public Health;Regimen;Research Personnel;Safety;simian human immunodeficiency virus;social;social stigma;Solid;Suspensions;System;Tail;Technology;Testing;Therapeutic;therapeutic effectiveness;Tissues;tool;Toxic effect;transmission process;treatment duration;Treatment Protocols;treatment strategy;User Compliance;Viral;Viral Load result;Viremia;virtual;Virus

PROJECT_TITLE: Ultra-long-acting Biodegradable and Tunable Polymeric Solid Implant for HIV Treatment Maintenance

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Telehealth

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE This project will contribute information to the evidence base about: 1.) whether telehealth can improve health outcomes and experiences for patients with ADRD; 2.) whether all types of telehealth technologies are equally important in improving health outcomes and experiences for patients with ADRD; and 3.) which agencies are most likely to adopt telehealth.

PI_NAMEs: MUKAMEL, DANA B (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;Advocate;Alzheimer's disease patient;Alzheimer's disease related dementia;Biological Monitoring;Blood;Bluetooth;Caregivers;Caring;Case Mixes;Characteristics;Chronic Obstructive Pulmonary Disease;cohort;Communication;Congresses;cost;COVID-19;COVID-19 pandemic;Data;Data Reporting;Data Sources;evidence base;experience;Family;Future;handheld mobile device;Health;Health Services;Health Surveys;Health Technology;Healthcare;Heart Diseases;Home;Home Care Services;Home Health Agency;Home Health Care Agencies;hospice environment;improved;Industry;insight;Link;Marketing;Measures;Medicare;Medicare claim;member;Methodology;Modality;Monitor;Natural experiment;Occupational Therapy;Outcome;Ownership;Oxygen;patient home care;Patient Monitoring;Patient-Focused Outcomes;Patients;Pattern;payment;Penetration;Persons;Physical therapy;Policies;Policy Maker;Population;Prevalence;Provider;remote patient monitoring;Reporting;Risk Adjustment;Stroke;Surveys;Technology;telehealth;Testing;traditional care;transmission process;trend;video visit;virtual visit;Visit;Voice;wound treatment

PROJECT_TITLE: Home Health, ADRD, Telehealth, and Patient Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-L(90)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DAVIS

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Intracrine steroidogenesis plays vital roles in resistance to abiraterone, enzalutamide and apalutamide. Steroidogenesis genes, such as AKR1C3, HSD3B and CYP17A1 not only play central roles in intracrine androgen biosynthesis, their presence is also closely correlated to disease stages. This proposal will be the first study that interrogates steroidogenesis genes and plasma steroid levels in next generation anti- androgen resistant prostate cancer patients and develop novel strategies using novel patient derived xenograft models to overcome drug resistance.

PI_NAMEs: LIU, CHENGFEI  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: abiraterone;Address;advanced disease;advanced prostate cancer;Androgen Antagonists;androgen biosynthesis;androgen deprivation therapy;androgen independent prostate cancer;Androgen Metabolism;Androgen Receptor;Androgens;Anti-androgen Therapy;Biological Availability;Biological Markers;Blood;Blood specimen;Cancer Etiology;Cancer Patient;cancer type;Castration;celecoxib;Cell Line;Cessation of life;Chronic;Clinical;Clinical Trials;clinically relevant;cohort;Combined Modality Therapy;comparison control;Core Facility;Correlative Study;CYP17A1 gene;Data;Decision Making;Disease;Disease Outcome;Disease Progression;Disease Resistance;Drug Kinetics;Drug resistance;effective therapy;efficacy evaluation;efficacy testing;enzalutamide;Enzymes;Ethics;experience;Failure;Future;Genes;Goals;Growth;Human;improved;improved outcome;In Vitro;in vivo;Indomethacin;inhibitor;Intervention;Lead Poisoning;liquid chromatography mass spectrometry;Liquid substance;Malignant neoplasm of prostate;Mediating;men;Messenger RNA;Modeling;Monitor;multicatalytic endopeptidase complex;Names;Neoadjuvant Therapy;new therapeutic target;next generation;novel;novel marker;novel strategies;Oral;Organoids;Outcome Study;Participant;Pathway interactions;patient derived xenograft model;Patient Selection;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmacodynamics;Pharmacologic Substance;Plasma;Play;precision medicine;Primary Neoplasm;Process;Production;programs;prostate cancer cell;prostate cancer cell line;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;Proteins;Protocols documentation;Regulation;Relapse;Reporting;Research;research clinical testing;Resistance;RNA;Role;Running;Sampling;Serum;side effect;Signal Transduction;small molecule;Steroid biosynthesis;Steroids;Structure;System;Testing;Testosterone;therapeutic target;therapy resistant;Time;Translating;Translations;treatment comparison;treatment response;tumor xenograft;Ubiquitin;United States;Up-Regulation;Work

PROJECT_TITLE: Targeting intracrine steroidogenesis in anti-androgen resistant prostate cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Kidney Disease;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: PATHOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Metastatic disease, or the spread of cancer cells from invasive primary tumor to distal organs through vasculature or lymphatics is responsible for majority of patient deaths and remains a clinical challenge. However, not all invasive tumors are metastatic. We identified targetable metastatic competence determinants by performing comprehensive integrated analysis of invasive metastatic and non-metastatic ccRCC tumors.

PI_NAMEs: MALLADI, SRINIVAS  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Address;antagonist;Attenuated;Automobile Driving;Biological Models;Blood capillaries;Blood Vessels;cancer cell;cancer genomics;Cancer Patient;Cell Differentiation process;Cell secretion;Cells;Cessation of life;chemokine;Chromatin;Classification;Clear cell renal cell carcinoma;Cleavage Under Targets and Release Using Nuclease;Clinical;Clinical Management;clinical practice;Competence;CXCL1 gene;cytokine;Data;Diagnosis;Diagnostic Neoplasm Staging;Disease;Disease Management;Distal;Enrollment;Eph Family Receptors;EPHA2 gene;epithelial to mesenchymal transition;Excision;Experimental Models;Family;Family member;follow-up;Genes;genetic manipulation;Genetic Transcription;Genomic Segment;Growth;Histologic;Homeobox;IL8RB gene;Image;Immediate-Early Genes;Immune;immune cell infiltrate;Immunologic Surveillance;improved;in vivo Model;Infiltration;inhibitor;Innovative Therapy;Invaded;Kidney Neoplasms;Knowledge;Ligands;Lymphatic;Macrophage;Mediating;Microscopic;migration;mimicry;Modeling;MRI Scans;Myelogenous;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;Nephrectomy;neutrophil;Nonmetastatic;Operative Surgical Procedures;Organ;Organoids;patient derived xenograft model;Patients;Peer Review;pharmacologic;Phosphotransferases;Primary Neoplasm;programs;prospective;receptor;recruit;Regimen;Renal Carcinoma;Resected;Residual Neoplasm;response;Role;Signal Transduction;single cell sequencing;standard of care;Structure;survival outcome;Survival Rate;Therapeutic;Thrombus;trait;transcription factor;Transcription Factor AP-1;transcriptomics;Transforming Growth Factor beta;tumor;tumor heterogeneity;Tumor Promotion;Vasculogenic;Work;X-Ray Computed Tomography

PROJECT_TITLE: ccRCC Metastatic Competency Determinants

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: PHILADELPHIA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE This application brings a unique combination of biophysical tools and molecular simulations together to study the HIV-1 envelope glycoprotein spike (Env), a complex molecular machine that mediates viral entry while evading the immune system. Our project will provide an unprecedented level of detail into Env conformational dynamics, enabling improved design of new antiviral entry inhibitors and stable immunogens needed for vaccine development.

PI_NAMEs: ABRAMS, CAMERON F (contact);MOTHES, WALTHER H;SODROSKI, JOSEPH G

PROGRAM_OFFICER_NAME: CHAKRABARTI, BIMAL KUMAR

PROJECT_TERMS: 3-Dimensional;Acceleration;Anti-viral Therapy;Antigens;Binding;biophysical techniques;biophysical tools;Biophysics;Cells;Characteristics;Complex;crosslink;Crosslinker;Data;design;Development;Equilibrium;experimental study;flexibility;Fluorescence Resonance Energy Transfer;fluorophore;Future;Generations;Glycoproteins;HIV-1;Immune;Immune Evasion;Immune system;immunogenicity;improved;inhibitor;Length;Lysine;Mass Spectrum Analysis;Mediating;Membrane;Methods;Modeling;Molecular;Molecular Conformation;molecular dynamics;Molecular Machines;Molecular Target;Monitor;Outcome;Positioning Attribute;Predisposition;Resolution;Role;Sampling;Schedule;simulation;single molecule;single-molecule FRET;small molecule;small molecule inhibitor;Specific qualifier value;Spectrum Analysis;Structure;Surface;Techniques;Temperature;Testing;Time;vaccine development;Vaccines;Viral;viral entry inhibitor;Viral Proteins;Virion;Virus;Work

PROJECT_TITLE: Combining Molecular Simulations and Biophysical Methods to Characterize Conformational Dynamics of the HIV-1 Envelope Glycoprotein


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Post-Traumatic Stress Disorder (PTSD);Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: BURLINGTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE  We recently demonstrated the initial feasibility of a novel Prolonged Exposure (PE) protocol for improving therapy attendance and PTSD symptoms among individuals maintained on MOUD. Here we propose to expand upon those promising preliminary findings by (a) conducting a more definitive evaluation of this novel PE intervention, (b) utilizing a novel telemedicine platform to reach rural underserved patients, and (c) following up on highly promising initial data suggesting that PE therapy may also be associated with improvements in illicit drug use. This study represents the first effort to examine the efficacy of PE delivered via telemedicine to individuals with OUD, and our investigative team is uniquely poised to disseminate our findings to improve clinical practice in real-world settings throughout the country.

PI_NAMEs: PECK, KELLY R. (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Address;Adherence;Adult;Agonist;Biochemical;Buprenorphine;clinical practice;clinically relevant;Cognitive Therapy;Country;COVID-19 pandemic;craving;Data;digital delivery;Dropout;Drug usage;efficacy evaluation;Enrollment;Evaluation;evidence base;experience;financial incentive;General Population;Grain;Health Personnel;health service use;Health Services Accessibility;illicit drug use;illicit opioid;improved;Individual;innovation;Intervention;Investigation;Knowledge;Measures;medication for opioid use disorder;Mental Health;Methadone;Modality;novel;Opioid;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;Participant;Patient Self-Report;Patients;Persons;physical conditioning;Pilot Projects;Population;Post-Traumatic Stress Disorders;Poverty;Protocols documentation;Questionnaires;Randomized;reduce symptoms;Reporting;Research;Risk;Rural;rural underserved;Sampling;satisfaction;Severities;social stigma;substance use;Substance Use Disorder;Symptoms;Telemedicine;Testing;Transportation;Trauma;trauma exposure;treatment as usual;Treatment outcome;underserved community;Urine;Visit;Vulnerable Populations

PROJECT_TITLE: Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals with OUD

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The visual sciences research cores have been updated and provide state-of-the-art and centralized research techniques such that work is performed in an efficient and standardized manner without the need to duplicate equipment and highly trained staff. The services available from the cores provide utility and increased productivity to all vision researchers at The University of Iowa.

PI_NAMEs: SHEFFIELD, VAL C. (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;Acute;Anterior;behavior measurement;Bioinformatics;Biometry;Biostatistics Core;Center Core Grants;Communication;Communities;Computing Methodologies;confocal imaging;cost;COVID-19 pandemic;COVID-19 testing;Data Set;database of Genotypes and Phenotypes;Electroretinography;Equipment;experience;experimental analysis;Experimental Designs;Faculty;Fluorescein Angiography;Funding;Fundus;Gene Expression;Goals;Gonioscopy;Grant;Histologic;improved;Investigation;Iowa;Laboratories;Laboratory Personnel;laser capture microdissection;Light;live cell imaging;meetings;member;Methods;molecular imaging;multidisciplinary;Mus;National Eye Institute;new technology;open source;Optical Coherence Tomography;Outcome;Phenotype;Photography;Physiologic Intraocular Pressure;Procedures;Productivity;programs;Pupil light reflex;Rattus;reconstruction;Reproducibility;Research;Research Activity;Research Personnel;Research Technics;Resources;response;Rodent;Roentgen Rays;Services;Standardization;Statistical Methods;Supervision;Technical Expertise;Techniques;Testing;Tissues;Training;Universities;Update;Vision;Vision research;vision science;Work

PROJECT_TITLE: Multidisciplinary Investigations in Visual Science


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biomedical Imaging;Eye Disease and Disorders of Vision

PI_NAMEs: MULLINS, ROBERT FOSTER (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Antibodies;Area;Cells;Charge;Collection;confocal imaging;Consult;Consultations;Data;Equipment;experience;Experimental Designs;Eye;Funding;Goals;Histologic;Human Resources;Image;imaging modality;Investigation;investigator training;Iowa;laser capture microdissection;Lectin;live cell imaging;member;Methods;microscopic imaging;Mission;Molecular;molecular imaging;Morphology;morphometry;multidisciplinary;Procedures;reconstruction;Research;Research Activity;Research Personnel;Resources;Scientist;Services;Stains;tissue processing;Tissue Sample;Tissues;Training;United States National Institutes of Health;Universities;Vision;Vision research;vision science

PROJECT_TITLE: Molecular Imaging Core


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: ANDERSON, MICHAEL G (contact)

PROJECT_TERMS: Acute;Address;Animal Husbandry;Anterior;Area;automated image analysis;Axon;behavior measurement;Biological;Biological Assay;Categories;Collaborations;Consult;Consultations;COVID-19;deep learning;Development;Dissection;Educational workshop;Electroretinography;equipment acquisition;Experimental Designs;experimental study;Eye diseases;Fees;Fluorescein Angiography;Funding;Fundus;Goals;Gonioscopy;Housing;Human Resources;Injections;Investigation;investigator training;Iowa;Light;Lighting;Measures;Mission;model organism;Modeling;multidisciplinary;Mus;Optic Nerve;pandemic disease;Phenotype;Photography;Physiologic Intraocular Pressure;Procedures;Pupil light reflex;Rattus;Reproducibility;Research Personnel;Resources;response;Retina;Retinal Ganglion Cells;Rodent;Science;Services;Slide;sperm cryopreservation;System;Temperature;Testing;Tissues;Training;United States National Institutes of Health;Universities;Vision;Vision research;vision science;Vision Tests

PROJECT_TITLE: Rodent Phenotyping Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: Nashville

ORG_DEPT: BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PI_NAMEs: TIRIAC, ALEXANDRE  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Action Potentials;Adult;axon guidance;cell cortex;Controlled Environment;Detection;Development;Dorsal;environmental enrichment for laboratory animals;Ephrin B Receptor;Exhibits;experience;experimental study;Eye;Fire - disasters;ganglion cell;Life;Maps;Molecular;Motion;Mus;optic flow;permissiveness;Pharmacogenetics;postnatal;Process;response;Retina;Retinal Ganglion Cells;Role;Sensory;Surface;Testing;Visual;visual deprivation;visual stimulus

PROJECT_TITLE: Development of direction selectivity maps


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Eye Disease and Disorders of Vision;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SCHEETZ, TODD E (contact)

PROJECT_TERMS: Address;Algorithms;analytical method;Area;Argon;Bioinformatics;Biometry;Biostatistics Core;Clinical;Clinical Data;clinical phenotype;cluster computing;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;computational platform;Computer software;Computing Methodologies;computing resources;Consultations;Custom;Data;data management;Data Set;database of Genotypes and Phenotypes;Databases;Dedications;deep learning;design;Development;Disease;exome;experience;Experimental Designs;experimental study;Eyeglasses;FAIR principles;Fees;Funding;Gene Expression;genetic risk factor;Genome;genome browser;genome resource;genome-wide;Genomics;Genotype;Goals;Guide RNA;heterogenous data;High Performance Computing;Human Resources;Image;imaging modality;improved;insight;integration site;Investigation;Iowa;Maps;Measurement;Measures;Mendelian randomization;Methods;Mission;mouse model;multidimensional data;multidisciplinary;novel;open source;phenotypic data;power analysis;Procedures;Publishing;repository;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Science;Scientist;Secure;Sequence Read Archive;Services;single-cell RNA sequencing;Standardization;Statistical Data Interpretation;statistics;System;Techniques;Technology;Testing;theories;Training;trait;Transgenes;United States National Institutes of Health;Universities;Variant;Vision research;vision science

PROJECT_TITLE: Bioinformatics and Biostatistics Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lung;Microbiome;Otitis Media;Pediatric;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Acute otitis media (middle ear infection) is the most common infectious disease in childhood and the leading cause of pediatric healthcare visits and antibiotic prescriptions. Ear infections have been linked to alterations in the microbial communities within the upper respiratory tract, known as the microbiome. This proposal seeks to evaluate clinical and microbiome characteristics that contribute to the development of middle ear infections in young children with the goal of identifying factors that may be suitable targets for new treatment and prevention methods.

PI_NAMEs: HURST, JILLIAN HEYWARD (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acute;Adolescent;Age;Age Months;Antibiotics;antimicrobial;Asthma;atopy;Award;bacteriome;Biochemistry;Biological;Birth;career;career development;Characteristics;Child;Child health care;Childhood;chronic respiratory disease;Clinical;Clinical Data;Clinical Research;cohort;Cohort Studies;Communicable Diseases;Corynebacterium;COVID-19;Data;Data Mart;data resource;Data Set;Development;Disease;dysbiosis;ear infection;ear microbiome;educational atmosphere;Electronic Health Record;Enrollment;Epidemiologist;Evaluation;experience;Exposure to;Functional disorder;Funding;Goals;Growth;gut microbiome;Health;health care service utilization;Health Care Visit;Home;host microbiome;Human Microbiome;Immune response;improved;Infant;Infection;Infectious Agent;Inflammatory Response;Integration Host Factors;Interdisciplinary Study;intrapartum;K-Series Research Career Programs;large datasets;Lead;Life;Link;Mediating;Mentors;Mentorship;metagenomic sequencing;Methodology;Methods;microbial;microbial community;microbiome;microbiome alteration;middle ear;middle ear fluid;Molecular Biology;Mothers;multidisciplinary;nasal swab;Nose;observational cohort study;Otitis Media;Otolaryngology;pathogen;Pathogenesis;pathogenic bacteria;Pattern;Pediatric Research;Physicians;Population;population health;Positioning Attribute;Predisposition;prevent;Prevention;programs;Prospective cohort;Public Health Informatics;Recording of previous events;Recurrence;recurrent infection;Research;Research Activity;Research Design;Research Personnel;research study;respiratory;respiratory health;respiratory microbiome;Respiratory Tract Infections;Risk;Role;Sampling;Scientist;Serotyping;sex;Specimen;Statistical Data Interpretation;Statistical Models;Streptococcus pneumoniae;Testing;therapeutic target;Time;Training;Training Activity;United States National Institutes of Health;Upper Respiratory Infections;Upper respiratory tract;Vaccination;virome;Wheezing;Work

PROJECT_TITLE: Clinical and host microbiome features in the development of acute otitis media

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: Los Altos

ORG_NAME: BACSTITCH DNA INC.

PHR: PROJECT NARRATIVE Industrial, academic and government research have increasing demand for long and complex DNA constructs. However, existing DNA assembly technologies to make these constructs are expensive, require considerable hands-on time and are difficult to multiplex and scale. The goal of this proposal is to harden, scale and commercialize a new in vivo DNA assembly technology that will both increase the throughput and reduce the cost of high quality, sequence verified, long and complex DNA construction.

PI_NAMEs: CRAFORD, DAVID  (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: Acceleration;Agar;analysis pipeline;antibody engineering;Bacteria;Bar Codes;base;Biotechnology;Businesses;cellular engineering;Cloning;combinatorial;commercialization;Complex;cost;Custom;Data Set;Databases;design,build,test;DNA;DNA biosynthesis;DNA Sequence;DNA Structure;drug development;Enzymes;flexibility;frontier;Future;Genes;Genetic;Genetic Conjugation;Genomics;Goals;Government;Grant;Guanine + Cytosine Composition;In Vitro;in vivo;Industrialization;large scale production;Libraries;Licensing;Marketing;meetings;metabolic engineering;Methods;new technology;novel;Oligonucleotides;Output;Partner in relationship;Pathway interactions;Pharmacologic Substance;Phase;Plasmids;Polymerase;Positioning Attribute;Preparation;Printing;Procedures;Production;programs;Provider;Reagent;Research;research and development;Robotics;Sequence Analysis;Services;Small Business Innovation Research Grant;Standardization;synthetic biology;System;Systems Analysis;Technology;Time;Validation

PROJECT_TITLE: Multiplexed in vivo assembly of long and complex DNA


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Cerebrovascular;Childhood Injury;Clinical Research;Neurosciences;Pain Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Stroke;Unintentional Childhood Injury

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Quinlan, Katharina Project Narrative This project pursues the hypothesis that in individuals with spastic cerebral palsy (CP), hypertonia, hyperreflexia and reflex irradiation may arise from changes in an aspect of sensorimotor processing known as primary afferent depolarization (PAD). This project will directly assess effectiveness of decreasing PAD through transcutaneous electrical nerve stimulation (TENS) in reducing hyperreflexia and hypertonia in CP. In summary, this study will measure the contributions of presynaptic modulation of Ia afferents to spasticity in CP and identify the most promising sites for therapeutic intervention.

PI_NAMEs: QUINLAN, KATHARINA ANN (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Agonist;Animal Model;Architecture;Asphyxia;Automobile Driving;Autopsy;Brain;Brain Hypoxia-Ischemia;Brain Stem;Cell Death;Cerebral Palsy;Child;Chronic;comorbidity;conditioning;Corticospinal Tracts;Defect;desensitization;Development;Disinhibition;Distant;Dyes;effectiveness evaluation;effectiveness testing;efficacy evaluation;Electric Stimulation;endogenous opioids;Failure;H-Reflex;Human;human tissue;Hyperreflexia;Immunohistochemistry;Impairment;In Vitro;in vivo;Individual;Infant;Injury;Interneurons;Investigation;irradiation;Label;Live Birth;Lumbosacral Region;Measures;Mediating;Modeling;Motor;motor deficit;Motor Neurons;Muscle;Muscle Hypertonia;muscle stiffness;neonate;nerve supply;Neurons;neurotransmission;Nociception;Nociceptors;Opioid;Opioid Receptor;Oryctolagus cuniculus;Outcome;Pain;Pathway interactions;Perinatal;perinatal brain;Perinatal Brain Injury;Perinatal Hypoxia;Persons;pharmacologic;Pharmacology;Phase;postnatal;pre-clinical;Pregnancy;prenatal;presynaptic;Prevalence;prevent;receptor;Reflex action;response;Rodent;Sensory;sensory stimulus;Site;Spastic Cerebral Palsy;spasticity;Spinal;Spinal Cord;Synapses;Testing;Therapeutic;Therapeutic Intervention;Thinness;Transcutaneous Electric Nerve Stimulation;white matter injury

PROJECT_TITLE: Impairment of Spinal Development in Cerebral Palsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE There is currently no clinically accepted way to predict a lung cancer's likely aggressiveness prior to removing the tumor via surgery, resulting in imprecise treatment. We propose to characterize the aggressiveness of early-stage lung adenocarcinoma (the most common lung cancer subtype) before treatment, based on detailed and quantitative analysis of chest CT and molecular analysis of a small biopsy of the tumor obtained before surgery. The ability to determine the aggressiveness of lung cancer could facilitate treatment tailored to individual patients: improving lung cancer survival in patients with the most aggressive tumors and decreasing complications from lung cancer treatment in patients with the least aggressive tumors.

PI_NAMEs: LENBURG, MARC ELLIOTT (contact);MALDONADO, FABIEN

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Ablation;Academic Medical Centers;Adjuvant;Adoption;Behavior;Bioinformatics;Biological;Biological Markers;biomarker performance;Biometry;Biopsy;Boston;Bronchoscopy;Cancer Detection;Cancer Etiology;cancer subtypes;cancer survival;cancer therapy;Cessation of life;Chest;chest computed tomography;Clinical;clinical care;clinical predictors;cohort;cost;Data;deep learning;Detection;Diagnosis;Disease;disorder risk;Enrollment;Excision;Gene Combinations;Gene Expression;Genetic Markers;Genomics;Goals;Health Care Costs;high risk;high risk population;Histologic;Histology;Histopathologic Grade;Hospitals;Image;improved;individual patient;individualized medicine;Indolent;Interventional radiology;Lesion;Lung;Lung Adenocarcinoma;lung cancer screening;Malignant neoplasm of lung;Measures;Medical center;Modeling;Molecular Analysis;Molecular Biology;molecular marker;Morbidity - disease rate;Morphologic artifacts;mortality;Neoadjuvant Therapy;novel;Operative Surgical Procedures;Outcome;overtreatment;Participant;Pathologic;Pathology;Patient observation;patient subsets;Patient-Focused Outcomes;Patients;Performance;personalized management;personalized screening;predictive marker;predictive modeling;primary endpoint;Prognosis;prospective;Prospective cohort;Radiology Specialty;radiomics;Recurrence;Research;Resected;Risk;Sampling;secondary endpoint;Specimen;survivorship;Systemic Therapy;Testing;Texture;Time;Tissues;Training;transcriptome sequencing;treatment strategy;tumor;tumor heterogeneity;Tumor Tissue;Universities;Validation

PROJECT_TITLE: Integrating imaging and biopsy-derived molecular markers for the pre-surgical detection of indolent and aggressive early stage lung adenocarcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-L(59)R]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disease that often leads to death within three years of diagnosis but requires about a year to diagnose. Part of the barrier to early diagnosis is the lack of an effective means to identify upper motor neuron dysfunction that often precedes the onset of clinical symptoms. We will conduct a rigorous investigation of a novel, safe, and non-invasive measure of upper motor neuron function to examine it’s potential in early detection of pathology associated with ALS.

PI_NAMEs: SOTO, OSCAR ;TUNIK, EUGENE  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Affect;ALS patients;Amyotrophic Lateral Sclerosis;Anatomy;Animal Model;awake;Behavior;Biological Markers;Cessation of life;Clinical;Clinical assessments;Clinical Trials;Code;Data;Data Collection;density;Dependence;Diagnosis;Diagnostic;Disease;disease heterogeneity;Disease Management;Disease Progression;early detection biomarkers;Early Diagnosis;efficacy evaluation;Electrodes;Evaluation;Exhibits;Failure;Functional disorder;Future;Generations;grasp;Hand;Heterogeneity;Human;Impairment;improved;Individual;innovation;Investigation;Isometric Contraction;Measures;Motor;Motor Evoked Potentials;motor neuron function;Motor Neurons;Muscle;neural;Neurodegenerative Disorders;neuromechanism;Neuronal Dysfunction;neurophysiology;novel;novel therapeutics;Onset of illness;Output;Pathology;patient stratification;Pattern;Persons;Physiological;Population;Process;Production;Quality of life;Ramp;rate of change;recruit;Research;response;Rest;Severity of illness;Signal Transduction;Speed;Stimulus;Surface;Symptoms;System;Testing;Time;tool;Transcranial magnetic stimulation;Trees

PROJECT_TITLE: Failure of Facilitation as a Biomarker in ALS

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: Columbus

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative. Rotaviruses (RVs) of group A (RVAs) remain an important cause of acute gastroenteritis and mortality in young animals and children; however, the mechanisms of their pathogenesis and replication remain understudied. We propose to conduct translational research to dissect the molecular mechanisms of RVA virulence and host receptor interactions using our innovative, complementary and physiologically relevant models including RVA reverse genetics system, gnotobiotic pigs and porcine small intestinal enteroids.

PI_NAMEs: SAIF, LINDA J.;VLASOVA, ANASTASIA NICKOLAEVNA (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;Address;Amino Acid Substitution;Attenuated;attenuation;Binding;Biological;Blood Group Antigens;Cell Adhesion;Cell Culture Techniques;Cell-Matrix Junction;Cells;Cessation of life;Child;Cholesterol;Clinical;comparative;design;diarrheal disease;Down-Regulation;Epithelial Cells;Excision;Family suidae;Gastroenteritis;Gene Exchanges;Gene Expression Profile;Genes;Genetic Transcription;genome analysis;Gnotobiotic;Goals;Heterogeneity;Human;Hydrophobicity;Immune signaling;improved;In Vitro;in vivo;Individual;Infection;innovation;intestinal epithelium;Intestines;juvenile animal;Knowledge;Metabolism;Modeling;Modification;Molecular;mortality;mutant;Mutation;Natural Immunity;Neuraminidase;novel;Pathogenesis;Phenotype;Physiological;Plasmids;Polysaccharides;porcine model;Positioning Attribute;Proliferating;Protocols documentation;receptor;recombinant virus;response;reverse genetics;RNA;Rotavirus;Sequence Analysis;Series;Severity of illness;Sialic Acids;Sialyltransferases;Signal Pathway;Small Intestines;Source;Specificity;System;Testing;Therapeutic;tool;transcriptome;Transfection;Translational Research;transmission process;vaccination strategy;Variant;vector;Viral Pathogenesis;Viral Physiology;Virulence;Virulent;Virus;Virus Receptors;Zoonoses

PROJECT_TITLE: Rotavirus Reverse Genetics System to Study Viral Pathogenesis and Receptor Interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VDT-Q(01)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Relevance  The proposed research aims to develop a novel PET tracer to image senescence cells in vivo. The ability of non-invasive imaging of senescence will help for both fundamental senescence research and development of senescence targeting therapeutics in treating cancer and ageing.

PI_NAMEs: RAO, JIANGHONG  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: 3-Dimensional;Address;Aging;Animal Cancer Model;Animal Model;Autophagocytosis;beta-Galactosidase;beta-galactoside;Biochemical;Biological;Brain Diseases;cancer imaging;Cancer Model;CASP3 gene;Cell Aging;Cell Culture Techniques;Cell Cycle;Cell Cycle Arrest;Cell Proliferation;cell type;Cells;cellular imaging;Chelating Agents;chemotherapy;Chemotherapy-Oncologic Procedure;Chromogenic Substrates;Colonic Neoplasms;Complex;Degenerative polyarthritis;design;Development;Diabetes Mellitus;Disease;DNA Damage;Doxorubicin;enzyme activity;Enzyme Kinetics;Enzymes;Fibrosis;Fluorine;Fucosidase;Future;Gadolinium;HCT116 Cells;healing;Homeostasis;Human;Hydrolase;Hydrolysis;Image;imaging detection;imaging modality;imaging platform;imaging probe;Immune system;Immunofluorescence Immunologic;Immunologic Surveillance;improved;In Situ;In Vitro;in vitro Assay;in vivo;in vivo imaging;Inflammation;interest;Kidney Diseases;Label;Macrophage;Magnetic Resonance Imaging;Malignant Neoplasms;meeting abstracts;Messenger RNA;Metabolic;Metabolic Diseases;Methods;Modeling;Monosaccharides;mouse model;nanoassembly;non-invasive imaging;novel;Oncogene Activation;Oncogenes;optical imaging;Optics;Osteoclasts;Oxidative Stress;Penetration;Peptide Hydrolases;Permeability;Photons;Positron-Emission Tomography;premature;Proliferation Marker;rational design;Reporting;Research;research and development;retention rate;Role;Secretory Cell;senescence;senescence associated secretory phenotype;senescent cell;Sensitivity and Specificity;Signal Transduction;Signaling Molecule;single photon emission computed tomography;small molecule;Specificity;Spiders;Stress;stressor;targeted treatment;Telomere Shortening;Tissue Stains;Tissues;Tracer;Translations;tumor;Tumor Suppression;tumor xenograft;uptake;Validation;Western Blotting;Work

PROJECT_TITLE: PET tracer for imaging senescence

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative People living with HIV (PLWH) are at increased risk of human papillomavirus (HPV)-associated oropharyngeal and oral cancers and disparities exist among racial/ethnic groups and sexual or gender minority groups (SGM). Through focus group discussions, this study will explore experiences accessing oral health care in PLWH that identify as members of different racial/ethnic and/or different SGM groups. These findings will inform the design of a multilevel, culturally appropriate intervention to increase engagement with oral health care and in HPV-associated OSCC/OPSCC prevention and screening activities.

PI_NAMEs: HERNANDEZ, ALEXANDRA LYDIA (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: acceptability and feasibility;Adolescent;aged;anti-racism;Anus;Benefits and Risks;black men;Black Populations;Black race;Cancer Etiology;Caring;Categories;cis-female;cis-male;culturally appropriate intervention;Data;Dental Care;Dental Insurance;Dental Offices;Dentists;design;Diagnosis;Discrimination;Disease;Disparity;Early Diagnosis;Education;ethnic identity;ethnic minority population;Ethnic Origin;Ethnic Population;experience;Face;feasibility testing;Focus Groups;Funding Mechanisms;Gender;Gender Identity;gender minority group;General Population;Goals;Grouping;Head and Neck Cancer;health equity;health inequalities;Health Insurance;Health Personnel;Healthcare;High Prevalence;Hispanic;HIV;Hospitals;Hour;HPV oropharyngeal cancer;HPV vaccine acceptance;HPV-High Risk;Human papilloma virus infection;human papilloma virus oropharyngeal squamous cell carcinoma;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;Improve Access;improved;Incidence;Individual;innovation;internalized stigma;intersectionality;Intervention;Knowledge;Latinx;malignant mouth neoplasm;Malignant Neoplasms;malignant oropharynx neoplasm;member;men;Mentors;Minority;mortality;Mouth Diseases;mouth squamous cell carcinoma;National Health and Nutrition Examination Survey;Neck;nonbinary;novel;Operative Surgical Procedures;oral care;Oral health;oral HPV infection;Oropharyngeal Squamous Cell Carcinoma;Outcome;Participant;Perception;Persons;preference;Prevalence;prevent;Prevention;Prevention program;Prevention strategy;preventive intervention;Primary Prevention;programs;Provider;Race;racial diversity;racial minority population;racial population;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Risk;Risk Assessment;Risk Factors;screening;Screening for Oral Cancer;screening program;Secondary Prevention;sex;Sexual and Gender Minorities;sexual minority;sexual minority group;Smoker;smoking prevalence;social stigma;Squamous cell carcinoma;Structural Racism;Suggestion;Surveys;Survival Rate;Tongue;Transportation;United States Preventative Services Task Force;uptake;Woman

PROJECT_TITLE: People living with HIV (PLWH), Oral and Oropharyngeal Cancer, and Health Equity: A Qualitative Study

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Colorectal Cancer;Dietary Supplements;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Ulcerative colitis (UC) significantly diminishes the quality of life of patients and increases the risk of infection and colorectal cancer. Based on my preliminary findings showing that specific diet-induced microbial metabolites trigger type 2 inflammation including eosinophilia in the intestine, the focus of this proposal is to dissect the role of the diet-microbiota axis in the regulation of intestinal inflammation. These studies will inform rational design of nutritional interventions and potentially reveal novel targets to improve therapeutic strategies for UC and colon cancer.

PI_NAMEs: ARIFUZZAMAN, MOHAMMAD  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Abdominal Pain;Address;Affect;Anemia;animal facility;Antiinflammatory Effect;Bacteria;bacterial genetics;bile acid metabolism;Bile Acids;bile salts;Biology;career;Cholic Acids;Chronic;Clinical;Colon;Colon Carcinoma;Colorectal Cancer;Communication;Complex;cytokine;Data;Diarrhea;Diet;dietary;Dietary Fiber;Dietary Intervention;Disease;Disease Outcome;Economic Burden;Environment;Environmental Risk Factor;eosinophil;eosinophil peroxidase;Eosinophilia;Epithelium;Etiology;experimental study;Fermentation;Fiber;Flow Cytometry;Food;Gastrointestinal Diseases;Genes;Genetic;Genetic Engineering;Germ-Free;Gnotobiotic;Goals;gut inflammation;Hemorrhage;host microbiota;Hydrolase;Immune response;Immunity;Immunology;immunoregulation;improved;Individual;infection risk;Inflammation;Inflammatory;Inflammatory Arthritis;Inflammatory Bowel Diseases;Inflammatory Response;inhibitor;Institution;instrument;Interleukin-4;Interleukin-5;Intervention;Intestines;Inulin;Laboratories;Lamina Propria;Lymphoid Cell;Malnutrition;Mediating;Mentors;mesenchymal stromal cell;Metabolic Pathway;metabolomics;microbial;microbiota;microbiota metabolites;Microscopy;migration;Modeling;Molecular;mouse model;Mucous Membrane;Mus;mutant;novel;Outcome;Pathogenesis;Pathologic;Pathology;Patients;Pattern;Phase;Phenotype;Postdoctoral Fellow;preventive intervention;Production;Public Health;Quality of life;rational design;receptor;Rectum;Regulation;Research;Research Personnel;response;Risk;Role;Severity of illness;Signal Transduction;skills;Stromal Cells;Symptoms;Testing;Therapeutic;Therapeutic Intervention;Tissues;Training Programs;Transgenic Mice;Ulcerative Colitis;United States;Up-Regulation;Volatile Fatty Acids;Work;Writing

PROJECT_TITLE: Dietary regulation of type 2 immunity and inflammation in the gut

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Lymphatic Research

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE To carry out their roles in host defense, T cells must traffic throughout the body in a process that is closely regulated by protein- and lipid-based chemoattractants. This proposal tests the mechanisms through which these signals coordinately control discrete aspects of T cell trafficking. The knowledge gained from these studies will be important for modulating T cell function in a variety of therapeutic settings.

PI_NAMEs: BURKHARDT, JANIS K. (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: 3-Dimensional;Actins;Actomyosin;Autoimmune Diseases;Back;Biological;Biological Assay;Bulla;CCL19 gene;CCL21 gene;cell motility;Cell Physiology;cell type;Cells;chemokine;Chemotactic Factors;Chemotaxis;Clinical;Collagen;Complement;Complex;Confined Spaces;constriction;Cues;Cytoskeleton;Data;Defect;Development;Disease;Ear;effector T cell;Environment;Event;Exhibits;Exposure to;G-Protein-Coupled Receptors;Gel;Geometry;Host Defense;Image;Immune;Immunologic Surveillance;in vivo;Inflammatory;inhibitor;insight;interest;interstitial;Knowledge;Ligands;Light;Link;Lipids;live cell imaging;Lymphatic;Lymphatic Endothelium;lymphatic vessel;Lymphoid Tissue;Malignant Neoplasms;Mediating;Microfilaments;Microfluidics;migration;Modeling;Molecular;Motility;Movement;Mus;Myosin ATPase;Myosin Light Chains;Nonmuscle Myosin Type IIA;novel therapeutic intervention;Pathway interactions;Peripheral;pharmacologic;Phospholipase;Phosphorylation;polymerization;Polymers;pressure;Process;Proteins;rational design;receptor;Regulation;response;rho;Role;Signal Induction;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Speed;sphingosine 1-phosphate;Stimulus;Surface;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Tissues;trafficking;Transplantation;Work

PROJECT_TITLE: Chemoattractant-specific T cell navigation of complex environments

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Diabetes and associated diseases are major health concerns in today’s society. The proposed research is relevant to the mission of the NIDDK because it examines a novel molecular mechanism of SWELL1 signaling in obesity-induced Type 2 diabetes. Exploring this novel pathway and intracellular signaling mechanism will expand our understanding of innovative therapeutic avenues for the treatment and prevention of obesity-induced diabetes.

PI_NAMEs: SAH, RAJAN  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: adipocyte biology;Adipocytes;Adipose tissue;Anions;arm;Biochemical;Cell membrane;Complex;CRISPR screen;CRISPR/Cas technology;defined contribution;detection of nutrient;Diabetes Mellitus;Diet;Disease;E protein;Endothelium;experimental study;FRAP1 gene;Funding;Genes;Glucose Intolerance;glucose uptake;GLUT 4 protein;Growth;growth factor receptor-bound protein 2;Health;High Fat Diet;Human;human tissue;Image;In Vitro;in vivo;Incidence;inflammatory marker;innovation;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Ion Channel;Knock-in Mouse;Knock-out;Knowledge;Label;Laboratories;Leucine;Leucine-Rich Repeat;Lysosomes;Mass Spectrum Analysis;Measures;Mediating;Metabolic;metabolic phenotype;Metabolic syndrome;Methods;Mission;Modeling;Molecular;Mus;mutant;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Obese Mice;Obesity;obesity prevention;obesity treatment;Organ;overexpression;Overnutrition;patch clamp;Pathway interactions;Patients;PIK3CG gene;Population;Prediabetes syndrome;protein expression;Proto-Oncogene Proteins c-akt;Publishing;Reagent;Research;response;Signal Pathway;Signal Transduction;Skeletal Muscle;Societies;superresolution microscopy;Swelling;Testing;Therapeutic;Tissue Expansion;Tissue Sample;Tissues;Visceral

PROJECT_TITLE: Tuning Adipocyte Size and Obesity through SWELL1

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Precision Medicine

PHR: PROJECT NARRATIVE The proposed research will expand and further validate the use of new metabolic imaging in Multiple Sclerosis (MS). New techniques for non-invasive assessment of neuroinflammatory and redox processes will be investigated in MS models, while metabolic imaging will be applied to monitor therapy response in people living with MS. Results from this proposal will serve to ameliorate clinical management of MS patients, help refine therapeutic regimens and, ultimately, lead to better outcome and patient quality of life.

PI_NAMEs: GORDON, JEREMY WILLIAM (contact);GREEN, ARI J

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Acetyl Coenzyme A;Acids;Address;Automobile Driving;Bicarbonates;Biochemical;Biological;Biological Assay;Biological Markers;brain metabolism;Clinical;Clinical Management;Clinical Research;clinical translation;Decarboxylation;Detection;Disease;Disease Progression;Disease remission;Enzymes;experience;first-in-human;Fumarates;Funding;Genomics;glutamyltransferase;Glycine;Glycolysis;Grant;Homeostasis;human study;human subject;Image;imaging approach;imaging biomarker;Immunology;immunomodulatory therapies;Impairment;improved;in vivo;Inflammation;Inflammatory;Infrastructure;Kinetics;Lactate Dehydrogenase;Lead;Lesion;Link;Macrophage;Magnetic Resonance Imaging;Managed Care;Measures;Metabolic;metabolic imaging;Metabolism;Methods;Microglia;Modeling;Monitor;mouse model;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;Nature;neuroimaging;neuroinflammation;non-invasive monitor;novel therapeutics;Outcome;outcome prediction;overexpression;Oxidation-Reduction;Oxidative Stress;Pancreas;Pathogenesis;Patients;personalized care;personalized medicine;Persons;Phenotype;Pilot Projects;Play;pre-clinical;prevent;Process;Production;Pyruvate;pyruvate dehydrogenase;Quality of life;radiological imaging;Reactive Oxygen Species;Regimen;Relapse;Reproducibility;Research;Resolution;respiratory;response;Role;Sampling;Scheme;specific biomarkers;spectroscopic imaging;Structure;success;Symptoms;Techniques;temporal measurement;Therapeutic;Therapy Evaluation;Time;Tissue Sample;Toxic effect;treatment choice;treatment response

PROJECT_TITLE: MR Metabolic Imaging of Multiple Sclerosis


NIH_SPENDING_CATS: Cancer;Genetics

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative The gene encoding the tumor suppressor protein p53 is the most frequently mutated gene in cancer. Therapeutics that restore p53 activity in cancer could have transformative impact on treatment of cancer patients. This proposal aims to understand requirements and mechanisms for restoring tumor suppressor activity to mutant p53 proteins in cancer.

PI_NAMEs: KAISER, PETER  (contact);RYCHNOVSKY, SCOTT D.

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Academia;Affect;Alleles;Amino Acids;Animal Model;Apoptosis;Binding;Bioinformatics;Biological;Biology;Biophysics;Biotechnology;cancer cell;Cancer Patient;cancer therapy;Cell Cycle Arrest;Cell Proliferation;Cells;Chemicals;Clinic;Clinical Trials;Collection;crosslink;Crystallography;Development;Diagnosis;DNA;DNA Binding;DNA Binding Domain;drug development;drug-like compound;experience;experimental study;Exposure to;Future;gain of function;Gene Expression;Genes;Genetic;Genetic Induction;Genetic study;Goals;Human;In Vitro;in vivo;inhibitor;Knowledge;Length;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Missense Mutation;Molecular;Molecular Conformation;mutant;Mutate;Mutation;novel therapeutic intervention;Oxidation-Reduction;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Positioning Attribute;prevent;Process;programs;Property;Proteins;reconstitution;Reporting;Series;Site;small molecule;Structure;Structure-Activity Relationship;success;System;targeted cancer therapy;Testing;Therapeutic;therapeutic protein;therapeutic target;tool;TP53 gene;translational therapeutics;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor progression;Tumor Suppression;Tumor Suppressor Proteins;United States

PROJECT_TITLE: Mechanisms of mutant p53 reactivation

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The UCSD Neurosciences Graduate Training Program combines rigorous, quantitative training across the full spectrum of neuroscience sub-disciplines with a proven ability to prepare next generation science leaders, through mentored research in world-leading laboratories and comprehensive professional development.

PI_NAMEs: BLOODGOOD, BRENDA L (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Neurosciences;Training Programs

PROJECT_TITLE: Neurosciences Graduate Training Program


NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Digestive Diseases;Nutrition;Obesity;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Obesity and excessive fat consumption increase the risk of pancreatic cancer, but how they contribute to tumor development is not completely understood. In this proposal, we aim to determine how dietary fatty acids directly modulate pancreatic lipid composition to drive the formation of one of the most lethal and incurable cancers. Results from this study may lead to novel targeted dietary and pharmacologic strategies for the prevention of pancreatic cancer and possibly other obesity-driven cancers.

PI_NAMEs: MUZUMDAR, MANDAR DEEPAK (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: 3-Dimensional;Acceleration;Acinar Cell;Adipose tissue;Albumins;Binding;cancer care;Cancer Etiology;Cell Culture System;Cell model;Cells;Cessation of life;cohort;conditional knockout;Consumption;Country;Cultured Cells;Data;Development;Diet;Diet Research;dietary;dietary approach;dietary excess;Dietary Fats;Dietary Fatty Acid;driving force;Duct (organ) structure;Ductal Epithelial Cell;experimental study;FASN gene;Fatty acid glycerol esters;Fatty Acids;feeding;Genes;Genetic;Genetic Models;Genetically Engineered Mouse;Goals;Health;High Fat Diet;Histologic;Human;human disease;In Vitro;in vitro Model;in vivo;inhibitor;Intake;Integration Host Factors;Isotopes;Knock-out;KRAS oncogenesis;Link;Lipase;lipid metabolism;lipidomics;Lipids;long chain fatty acid;Lysophospholipids;Malignant neoplasm of pancreas;Malignant Neoplasms;Membrane;Metabolic;Metaplasia;Methods;Modeling;Monounsaturated Fatty Acids;Mus;non-genetic;Nonesterified Fatty Acids;novel;Obesity;Oleic Acids;Organoids;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic tumorigenesis;Pathway interactions;pharmacologic;Phospholipids;Plasma;Population;premalignant;Prevalence;Prevention strategy;Process;Production;Radioactive;Radioisotopes;receptor;Risk;Side;Source;Supplementation;Survival Rate;Testing;Time;Tissues;Tracer;tumor;tumor progression;tumorigenesis;tumorigenic;United States;Up-Regulation;uptake;Variant;Work

PROJECT_TITLE: Dietary fatty acids drive pancreatic cancer development

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


NIH_SPENDING_CATS: Bioengineering;HIV/AIDS

ORG_CITY: CHICAGO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE This project develops and applies multiscale molecular dynamics computer simulations, in close collaboration with experimental studies, to gain key insight into the release and maturation of HIV-1 particles (virions) from infected cells. The simulations and collaborative experiments address the role of complex protein assemblies in the maturation process, including the cleavage of the Gag protein and its assembly into the virus capsid that encases the viral genome within the virion, plus the ESCRT protein- mediated virion release process from infected cells. Taken as a whole, this body of research will provide fundamental knowledge on key steps of the HIV-1 virus lifecycle, with the potential to also inform the development of new therapeutic strategies to treat HIV-1 infection.

PI_NAMEs: VOTH, GREGORY A. (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Address;Anions;atomic interactions;Binding;Biological;biophysical techniques;Capsid;Cell membrane;Cell Physiology;Cells;Collaborations;Complex;Computer Models;Computer Simulation;Crowding;Data;Development;Environment;Evolution;experimental study;Freedom;Funding;gag Gene Products;Genome;Glycoproteins;Grain;Growth;Guide RNA;Hand;HIV Protease;HIV-1;HIV-1 protease;In Vitro;in vivo;Infection;innovation;insight;Investments;Kinetics;Knowledge;Letters;Life Cycle Stages;Link;Mediating;Membrane;Methodology;Methods;model development;Modeling;Molecular;molecular dynamics;molecular modeling;molecular scale;Morphology;novel;novel therapeutic intervention;Nucleic Acids;particle;Pathway interactions;Physical condensation;Process;Property;protein complex;Proteins;recruit;Research;Research Personnel;Resolution;Reverse Transcription;Ribonucleoproteins;RNA;Role;self assembly;simulation;Site;Structure;tool;Viral;Viral Genome;Viral Proteins;Virion;virology;Virus;Virus Assembly;Work

PROJECT_TITLE: Multiscale Simulation of HIV-1 Virion Release and Maturation


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Binding to the CD4 receptor triggers conformational changes in the metastable HIV-1 envelope glycoprotein trimer that activate its potential to mediate virus entry. CD4-mimetic compounds, small organic molecules that mimic the CD4 receptor, bind to the envelope glycoprotein trimer and prematurely trigger it, leading to irreversible inactivation. We describe novel, more potent CD4-mimetic compounds that provide a platform for further improvement, enable exploration of the basis of susceptibility/resistance among primary HIV-1 strains and allow better definition of the mechanisms underlying the antiviral potency of CD4-mimetic compounds.

PI_NAMEs: HENDRICKSON, WAYNE A.;HURYN, DONNA M;SODROSKI, JOSEPH G (contact)

PROGRAM_OFFICER_NAME: ZHOU, YAN

PROJECT_TERMS: analog;Animal Model;anti-viral efficacy;Antibodies;antibody-dependent cell cytotoxicity;Binding;Binding Sites;CCR5 gene;CD4 Antigens;Cell membrane;Cells;Consent;cost;CXCR4 gene;cytotoxic;design;Elements;Exhibits;fitness;Glycoproteins;HIV;HIV Envelope Protein gp120;humanized mouse;improved;indoline;inhibitor;Knowledge;Lead;Mediating;Membrane;Membrane Fusion;mimetics;Molecular Conformation;Monkeys;Mucous Membrane;neutralizing antibody;novel;Phenylalanine;Predisposition;premature;prophylactic;Proteins;prototype;rational design;receptor;Receptor Cell;Resistance;Sampling;scaffold;simian human immunodeficiency virus;small molecule;Structure;Surface;synergism;Testing;Therapeutic;Vaccines;Vagina;Variant;Vestibule;Viral;viral resistance;Virion;Virus;Virus Diseases;virus envelope;Virus Replication;Writing

PROJECT_TITLE: Probing functional HIV-1 envelope glycoprotein conformations with novel potent CD4-mimetic compounds


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Precision Medicine

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative While functional mitral regurgitation (FMR) portends a bleak prognosis, there is much controversy regarding what defines severe FMR as well as the optimal therapeutic strategy to improve clinical outcomes. Currently, there is no consensus regarding the most clinically relevant classification for FMR severity, optimal targets for therapy, or criteria for patient selection. The goal of the current research is to develop personalized risk prediction for FMR patients through explainable unsupervised phenomapping enriched with advanced CMR imaging biomarkers, and to determine the CMR predictors of reverse remodeling following and FMR evolution in patients undergoing modern therapies for FMR.

PI_NAMEs: KWON, DEBORAH  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Address;analytical method;Anatomy;Biological;biological heterogeneity;Cardiac;cardiac magnetic resonance imaging;Cardiomyopathies;Cardiovascular system;Characteristics;Classification;Clinical;clinical heterogeneity;Clinical Trials;clinically relevant;Complex;Consensus;Databases;Death Rate;Devices;Dimensions;disease classification;Disease-Free Survival;Echocardiography;Evolution;Goals;Guidelines;Heart failure;Heterogeneity;imaging modality;improved;improved outcome;Infarction;Intervention;Ischemia;Left;Left Ventricular Remodeling;Longitudinal Studies;longitudinal, prospective study;Machine Learning;Magnetic Resonance;magnetic resonance imaging biomarker;Medical;Methods;Mitral Valve;Mitral Valve Insufficiency;Modernization;mortality risk;novel;Outcome;Outcome Assessment;outcome prediction;patient population;Patient Selection;Patients;Pattern;personalized risk prediction;Phenotype;Positioning Attribute;Prediction of Response to Therapy;Prevalence;Process;Prognosis;radiomics;repaired;Reproducibility;Research;response;Risk;risk stratification;Selection Criteria;Severities;targeted treatment;Testing;Texture;Therapeutic;Tissues;Treatment Failure;Treatment outcome;United States;Ventricular

PROJECT_TITLE: Improving Phenotypic Classification and Prediction of Treatment Outcomes in Patients with Non-ischemic Cardiomyopathy and Functional Mitral Regurgitation

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: New treatments for serious neurological diseases affecting children and adults are needed. The Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT) was created to accelerate the development of new treatments by removing barriers to progress. Our Kennedy Krieger Institute and Johns Hopkins University (KKI- JHU) team has expertise in neurology clinical trials, resources to efficiently conduct trials, access to a large population, and focus on mentoring and inclusion that will add unique value to NeuroNEXT. The collective efforts will support advancement in the development of new treatments for people with neurological conditions.

PI_NAMEs: AUGUSTINE, ERIKA  (contact);MOWRY, ELLEN M.

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Agreement;Autoimmune encephalitis;Brain Injuries;career;Caring;Child;Childhood;Clinical;Clinical and Translational Science Awards;clinical development;Clinical Research;Clinical Trials;Collaborations;community engaged approach;community engagement;community research;Complex;Conduct Clinical Trials;Consultations;Data Coordinating Center;Dedications;design;Development;Disease;diversity and equity;diversity and inclusion;early phase clinical trial;Educational Activities;Enrollment;Ensure;Environment;Epilepsy;Equity;Ethnic Origin;experience;Failure;Foundations;Funding;gene-targeted therapy;Genetic;Geographic Locations;Goals;Huntington Disease;improved;Individual;Infrastructure;innovation;Institution;Institutional Review Boards;interdisciplinary approach;Intervention;Leadership;Learning;life span;medical schools;member;Mentors;Mentorship;Migraine;Mission;Multi-Institutional Clinical Trial;Multicenter Trials;multidisciplinary;Musculoskeletal System;Myopathy;National Center for Advancing Translational Sciences;Nervous System Disorder;Neurodevelopmental Disorder;Neurologic;Neurologist;Neurology;Neurosciences;neurosurgery;next generation;novel therapeutics;operation;Participant;patient population;Patient Representative;Patients;Persons;Phase;Population;Positioning Attribute;Process;Productivity;programs;Race;rare condition;Rare Diseases;Recommendation;Recording of previous events;recruit;Research;Research Personnel;Resources;Sampling;Site;socioeconomics;Spinal Injuries;success;Talents;Therapeutic Intervention;therapy development;Time;Training;Training Programs;Translational Research;Universities;Voice;Workforce Development

PROJECT_TITLE: Kennedy Krieger Institute - Johns Hopkins University NeuroNEXT Site


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Genetics;Immunotherapy;Nanotechnology;Radiation Oncology;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

ORG_STATE: MI

PHR: Project Narrative The proposed research aims to explore new approaches to stimulate antitumor immune response in triple negative breast cancer. Our study will show that the use of targeted gold nanoparticle together with radiation treatment can change the immune profile of tumor tissue into an environment promoting antitumor immune response. This work is directly relevant to public health as the findings of this study will help the design of immunotherapeutic interventions that will improve clinical outcome and survival in patients with triple negative breast cancer as well as the other cancer types.

PI_NAMEs: JANIC, BRANISLAVA  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Adjuvant;Animals;anti-cancer;anti-tumor immune response;antitumor effect;Breast Cancer Cell;Breast Cancer Model;Breast Cancer therapy;cancer cell;cancer immunotherapy;cancer radiation therapy;cancer type;Cell Survival;Cells;Chemicals;Clinical;Combination Drug Therapy;Combination immunotherapy;cyanine dye 5;cytokine;Data;design;DNA Damage;Drug Carriers;Drug Delivery Systems;Dyes;Enhancers;Environment;Enzyme-Linked Immunosorbent Assay;Exhibits;Future;Goals;Growth;Immune;immune checkpoint blockers;Immune system;immunogenic cell death;immunogenicity;Immunologic Stimulation;immunomodulatory therapies;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;in vivo optical imaging;Incubated;innovation;interest;Intervention;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Microscopy;Molecular;Mouse Cell Line;mouse model;multimodality;Mus;nanoGold;Nature;Neoadjuvant Therapy;Neoplasm Metastasis;novel strategies;Optics;Outcome;Pathway interactions;Patients;Pattern;Phenotype;Primary Neoplasm;Production;Prognosis;Property;prospective;Public Health;Publishing;Quantitative Reverse Transcriptase PCR;Radiation;radiation effect;Radiation therapy;Radiation-Sensitizing Agents;Radiosensitization;recruit;Research;response;RNA chemical synthesis;Role;siRNA delivery;Small Interfering RNA;Survival Rate;Testing;Therapeutic;Therapeutic Effect;Therapeutic immunosuppression;Transforming Growth Factor beta;Transmission Electron Microscopy;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Tissue;Tumor-infiltrating immune cells;uptake;Work;Xenograft Model;zeta potential

PROJECT_TITLE: siRNA-based Gold Nanoparticles as a Therapeutic Enhancer for Triple Negative Breast Cancer (TNBC) Radiotherapy


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Cardiovascular;Diabetes;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative Diabetic cardiomyopathies (T2DCM) are a leading cause of death nationwide and understanding metabolic interplay in the heart is crucial for the development of new therapies. Our research team will use human induced pluripotent stem cells (iPSCs) to generate cardiovascular cell types for in vitro modeling of T2DCM for the determination of altered metabolic pathways, functional phenotyping, and protein targets. Then, we will analyze diabetic mouse hearts to validate cardiac protective mechanisms at single-cell resolution.

PI_NAMEs: LIAO, RONGLIH ;MERCOLA, MARK ;WU, JOSEPH C. (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: 3-Dimensional;Ablation;Age;Animal Model;Binding;Binding Proteins;Blood Pressure;Blood Vessels;Calcium;Cardiac;Cardiac Myocytes;cardiac tissue engineering;cardioprotection;Cardiovascular Diseases;Cardiovascular Models;Cardiovascular system;Cause of Death;Cell Line;Cell Physiology;cell type;Cells;Circulation;Conditioned Culture Media;Coronary;Coronary Arteriosclerosis;COVID-19 pandemic;CRISPR/Cas technology;design;Development;Diabetes Mellitus;diabetes pathogenesis;diabetic;diabetic cardiomyopathy;Diabetic mouse;directed differentiation;Echocardiography;Endothelial Cells;endothelial stem cell;Epigenetic Process;ethnic diversity;Excretory function;extend lifespan;Fibroblasts;Genes;Genetic;genetic variant;genome sequencing;Glucose;glucose tolerance;glucose uptake;Grant;Heart;Heart Diseases;heart function;High Fat Diet;Histology;human induced pluripotent stem cells;Hypertension;Hypertrophy;Image;In Vitro;in vitro Model;induced pluripotent stem cell;induced pluripotent stem cell technology;inhibitor;Journals;Kidney;Mass Spectrum Analysis;Measures;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolic phenotype;metabolomics;migration;Mitochondria;Modality;Modeling;Molecular;mortality;mouse model;Mutation;Myocardial;Myocardial dysfunction;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;Paper;Pathology;Pathway interactions;patient subsets;Patients;Peptides;Phenotype;Point Mutation;Proliferating;Proteins;Proteolysis;Proteomics;Protocols documentation;Publications;Publishing;Qi;Reporting;Research;Resolution;Respiration;Role;sex;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Sodium;stem cell model;stem cells;symporter;Systems Biology;Therapeutic;Tissue Harvesting;Tissues;Type 2 diabetic;Validation;whole genome

PROJECT_TITLE: Human iPSC Model to Elucidate Metabolic Interplay in Diabetic Cardimyopathy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Pediatric

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE This longitudinal project will chart the trajectory of language comprehension in the primary grades and develop and validate measures of language comprehension which are important for literacy and academic progress. This project is relevant to the NIDCD’s mission to improve the lives of individuals with communication disorders because results will yield improved identification of children with developmental language disorder (DLD) as well as other children with language difficulties that may impact reading comprehension and other academic skills, allowing for earlier treatment to promote positive outcomes. This project is also relevant to the broader field of public health because of the importance of language and reading skills to overall quality of life.

PI_NAMEs: ADLOF, SUZANNE M. (contact);HENDRICKS, ALISON

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Academic skills;Acceleration;access disparities;Achievement;Adoption;Affect;aged;analytical method;Back;bilingualism;Calibration;Caregivers;Characteristics;Child;Child Support;Classification;Clinical;cohort;Communication impairment;comprehension skill;Data;Derivation procedure;design;Development;Diagnosis;Diagnostic;Disease;Disparity;dual diagnosis;Dyslexia;Early treatment;Education;elementary school;Employment Opportunities;epidemiology study;Ethnic Origin;Exhibits;experience;fall risk;falls;Future;Goals;Growth;Health Services Accessibility;Impairment;improved;Individual;innovation;Instruction;kindergarten;Language;language comprehension;Language Development;Language Development Disorders;Language disability;Language Disorders;Life;Linguistics;literacy;longitudinal design;Measurement;Measures;Mission;Modeling;Monitor;National Institute on Deafness and Other Communication Disorders;Neurodevelopmental Disorder;novel;Outcome;Patient Recruitments;peer;Performance;Population;pragmatic implementation;Psychometrics;Public Health;Quality of life;Race;Reading;reading ability;reading comprehension;reading difficulties;Reporting;Research;Research Design;Research Personnel;Risk;Sampling;Sampling Studies;School-Age Population;Schools;screening;Services;skills;Socioeconomic Status;Specificity;Speech and language services;spelling;standardize measure;Students;Support System;syntax;System;teacher;third grade;Time trend;tool;Variant;Vocabulary;Work

PROJECT_TITLE: Measuring Language Comprehension Development in the Primary Grades

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

PHR: Malaysia, a middle-income country that has an expanding HIV epidemic concentrated in people who inject drugs is steeped in high levels of discrimination and intentions to discriminate by HIV treating clinicians. We propose to develop and pilot test a rapid start antiretroviral therapy strategy that we will pilot test as a stigma reduction intervention, which if effective, can be tested in future implementation trials.

PI_NAMEs: ALTICE, FREDERICK LEWIS (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: addiction;Address;Adherence;Administrator;Affect;Africa South of the Sahara;Anti-Retroviral Agents;antiretroviral therapy;anxiety reduction;Architecture;Asia;Behavior;Behavioral;Clinical;clinically relevant;Cohort Studies;Collaborations;comorbidity;Consensus;Country;Data;Decision Making;design;Development;Diagnosis;Discrimination;Drug usage;Education;Elements;Eligibility Determination;Epidemic;evidence base;experience;Face;Future;future implementation;Goals;Guidelines;Health;Health Personnel;Healthcare;Hepatitis C virus;HIV;Hybrids;implementation trial;Imprisonment;improved;improved outcome;Incidence;Income;Individual;Infection;Injecting drug user;Intention;Intervention;intervention refinement;Life;low and middle-income countries;Malaysia;Mediating;Medical Students;medication for opioid use disorder;Methods;mortality;Needle-Exchange Programs;opioid use disorder;Opportunistic Infections;Pathway interactions;Patients;peer;Perception;Persons;Physicians;pilot test;Policies;Population;Prejudice;Prevalence;Process;Productivity;Protocols documentation;Provider;rapid test;Recommendation;Research;Research Methodology;Resources;sex;Sexual Partners;Social Class;social stigma;Social support;Stereotyping;System;systematic review;Techniques;Testing;Therapeutic Intervention;therapy adherence;therapy design;therapy development;Time;tool;transmission process;treatment as prevention;Treatment outcome;Trust;Universities;Viral;Vitamins;Work

PROJECT_TITLE: Reducing Stigma in People Who Inject Drugs with HIV Using a Rapid Start Antiretroviral Therapy Intervention

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: SURGERY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE Hepatocellular carcinoma (HCC) is the second most common cause of cancer related deaths worldwide with limited therapeutic options. This project addresses the important issues related to the clinical and biological implications of how one deregulated protein can alter the transcriptome to promote HCC. Specifically, the study seeks to determine the impact of targeting this protein to decrease tumor burden.

PI_NAMEs: DANG, HIEN T. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Address;Affect;Antisense Oligonucleotides;Asian Pacific Islander;Binding;Binding Sites;Biochemical;Biological;Biological Assay;biophysical analysis;Biophysics;Black Populations;Cancer Etiology;Cell model;Cell Nucleus;Cell Proliferation;Cessation of life;Chromatin;Chromatin Remodeling Factor;Clinical;Data;Death Rate;Diagnosis;E protein;Etiology;Event;Exclusion;Exons;Gene Amplification;Gene Expression;gene regulatory network;Genetic Models;Genetic Transcription;genome editing;Genotype;Germ Lines;Goals;Hepatocarcinogenesis;Hispanic Populations;In Vitro;in vivo;Invaded;Knock-in;Liquid substance;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;Maps;Mediating;Membrane;migration;Molecular;multiple omics;MYC gene;MYC Gene Amplification;negative elongation factor;Negative Finding;Not Hispanic or Latino;novel;Nucleosomes;Oncogenic;Organelles;overexpression;Patients;Phase;Phenotype;Physical condensation;potential biomarker;Primary carcinoma of the liver cells;Process;Prognosis;promoter;Protein Isoforms;protein protein interaction;Proteins;Proto-Oncogenes;Recombinant Proteins;Recurrent tumor;Reporting;Resolution;RNA Recognition Motif;RNA Splicing;Role;Signal Transduction;SMARCB1 gene;SWI/SNF Family Complex;Testing;Therapeutic;therapy development;Time;tool;transcriptome;tumor;Tumor Burden;tumor heterogeneity;tumorigenesis;tumorigenic

PROJECT_TITLE: Deciphering the role of NELFE in modulating MYC signaling in HCC


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Young cisgender women (YCW) in Kenya are affected by HIV at a disproportionate rate. We will develop, pre-test, and pilot test an ethnodrama intervention designed to transform community member beliefs about and foster support of YCW using PrEP, thereby reducing enacted, anticipated, and internalized stigma. We aim to create a supportive environment where young women’s PrEP use is normalized, rather than stigmatized.

PI_NAMEs: CORNELI, AMY LYNN (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Advanced Development;Affect;Africa South of the Sahara;African;Age;AIDS prevention;Area;Attitude;Behavioral;Belief;cis-female;Clinic;Cohort Studies;communication theory;Communities;community intervention;County;Data;design;Drama;Ecology;Educational workshop;Effectiveness;expectation;experience;Family member;Female;Female Adolescents;Festival;Film;Fogarty International Center;Fostering;Gender;Geographic Locations;Government;Grant;Health Personnel;HIV;HIV Infections;implementation evaluation;Incidence;Individual;Infection;innovation;internalized stigma;Intervention;intervention effect;Interview;Kenya;Lead;Length;Location;male;Male Adolescents;Marketing;Measures;member;Methods;Motivation;National Institute of Mental Health;Participant;patient engagement;peer;Perception;Performance;Persons;pilot test;Population;pre-exposure prophylaxis;Process;programs;Provider;Random Allocation;Research;Research Design;response;Role;scale up;Series;Sexuality;Site;social;Social Change;social norm;social stigma;Stigmatization;supportive environment;Testing;therapy design;Time;Transportation;uptake;virtual;young man;young woman;Youth

PROJECT_TITLE: Designing an Ethnodrama Intervention Addressing PrEP Stigma Toward Young Women


NIH_SPENDING_CATS: Cancer;Nutrition

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE Solute Carrier (SLC) transporters mediate the transport of ions, nutrients, drugs, and toxins, across biological membranes, and play a key role in disease, by supporting the hyper-proliferative cells’ increased reliance on nutrients. Our broad goal is to describe the substrate and inhibitor specificity in nutrient transporters and develop strategies to control their function via an integrated experimental and computational approach. This work will allow us to develop computational and chemical tools to study emerging therapeutic targets, characterize structure/function relationships in understudied proteins, and ultimately, provide a unique strategy to deprive nutrients and starve malignant cells, greatly benefitting human health.

PI_NAMEs: SCHLESSINGER, AVNER  (contact)

PROJECT_TERMS: Alanine;Allosteric Site;amino acid metabolism;Amino Acid Transporter;Amino Acids;analog;Anti-viral Agents;Autoimmune Diseases;Basic Amino Acid Transport Systems;Binding;Binding Sites;Biochemical;Biochemical Pathway;Biological;Biological Assay;Biology;Biomass;biophysical techniques;Biophysics;cancer cell;Cancer cell line;cancer type;Cell Death;Cell Differentiation process;Cell Line;Cell Proliferation;Cells;Cellular Metabolic Process;Chemicals;Collaborations;computational chemistry;Computing Methodologies;Coupled;Cryoelectron Microscopy;Cysteine;Data;design;Development;Diabetes Mellitus;Disease;Docking;Drug Delivery Systems;Drug Design;drug discovery;Drug Targeting;Electrophysiology (science);Electrostatics;Family;Free Energy;Future;Glutamine;Goals;Grant;Health;Human;Hydrophobicity;Hyperactivity;inhibitor;innovation;Ion Transport;Ions;Kinetics;Knowledge;Laboratories;Leucine;Libraries;Ligands;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Melanoma;Membrane;Membrane Transport Proteins;Metabolic Diseases;Metabolism;Methods;Modeling;Molecular;Molecular Conformation;Myocardial Ischemia;neoplastic cell;Nervous System Disorder;Neurotransmitters;novel;novel strategies;Nutrient;Organic Synthesis;Pathology;Pharmaceutical Preparations;Pharmacology;Physiological;Play;Prodrugs;Proliferating;Proteins;rapid growth;rational design;Role;Serine;Shapes;Signaling Molecule;Site-Directed Mutagenesis;small molecule;solute;Specificity;Starvation;structural biology;Structural Models;Structure;Structure-Activity Relationship;Substrate Specificity;Sugar Acids;Synthesis Chemistry;T-Lymphocyte;Testing;therapeutic target;tool;Toxin;triple-negative invasive breast carcinoma;uptake;virtual;Work

PROJECT_TITLE: Substrate Specificity Determinants in Nutrient Solute Carrier Transporters

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Sound salience processing during sleep enables rapid arousal when a behavioral response is appropriate, such in the presence of danger, yet how the brain extracts sound meaning during sleep and the consequences of this processing for sleep-dependent cognitive processes is largely unknown. The proposed research will utilize electrophysiological and optical recordings from multiple brain regions, closed-loop sound manipulations and light-activated modulation of neural activity in freely behaving and naturally sleeping mice to identify the neural mechanisms and mnemonic consequences of sound processing during sleep.

PI_NAMEs: EBAN-ROTHSCHILD, ADA ;ROTHSCHILD, GIDEON  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Acoustics;Acute;Address;Amendment;Arousal;Auditory area;Auditory system;Behavioral;behavioral response;Brain;Brain region;Chronic;cognitive process;Communication;cost;Dependence;Dopamine;dopaminergic neuron;Electroencephalography;Electrophysiology (science);epidemiology study;Event;experimental study;Exposure to;Familiarity;Health Policy;Hippocampus;Household;Impaired cognition;Impairment;Infant;insight;Investigation;Joints;Knowledge;Light;Link;long term memory;Memory;memory consolidation;Memory impairment;memory process;memory retention;Mus;Names;Neighborhoods;neural;neuromechanism;Neurons;neurophysiology;Noise;noise exposure;noise pollution;novel;Nucleus Accumbens;Optics;optogenetics;Pattern;Persons;Process;Property;Public Health;Research;Rodent;Role;semantic processing;Semantics;Signal Transduction;Sleep;Sleep disturbances;sound;Stimulus;Testing;urban setting;Ventral Tegmental Area;Wakefulness

PROJECT_TITLE: The neural mechanisms and mnemonic consequences of sound processing during sleep

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Genetics;Human Genome;Lung;Pulmonary Fibrosis;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Pulmonary fibrosis is a devastating disease with few therapeutic options and caused by accumulation of pathologic fibroblasts, which produce excessive amounts of extracellular matrix. Molecular detail of pathologic fibroblasts remained poorly understood due to the lack of specific markers and methodology to investigate them. Here we propose to reveal the function and transcriptional landscape of pathologic fibroblasts by using a recently generated mouse strain, which can specifically target pathologic fibroblasts in pulmonary fibrosis.

PI_NAMEs: TSUKUI, TATSUYA  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Ablation;Adoptive Transfer;Alveolar;Apoptosis;ATAC-seq;Award;Binding;Bleomycin;Candidate Disease Gene;candidate identification;Cell Count;Cell Cycle Kinetics;Cell Physiology;Cells;ChIP-seq;Chromatin;Chronic;Cicatrix;Collagen;Collagen Gene;Computer Analysis;conditional knockout;Data;Deposition;design;Deterioration;Development;Disease;Effector Cell;Epigenetic Process;epigenetic regulation;experimental study;Extracellular Matrix;Fibrillar Collagen;Fibroblasts;fibrogenesis;Fibrosis;fibrotic lung;functional genomics;Gases;Gene Expression;Gene Modified;Genes;Genetic;genetic approach;Genetic Transcription;Genome;Genomic approach;Goals;Human;idiopathic pulmonary fibrosis;Impairment;In Situ Hybridization;in vitro Assay;in vivo;Inflammation;injured;Injury;innovation;knock-down;knockout gene;Knowledge;Label;Lung;lung development;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Methodology;migration;Modeling;Molecular;Morphology;mouse development;Mouse Strains;Mus;Normal tissue morphology;novel;overexpression;Pathologic;Patients;Phase;Phenotype;Play;Population;Process;programs;Proliferating;Proteins;Protocols documentation;Pulmonary Fibrosis;Regulator Genes;Reporter;Resolution;Respiratory physiology;RNA;Role;single cell ATAC-seq;single-cell RNA sequencing;Site;skills;success;Survival Rate;Therapeutic;therapeutic development;therapeutic target;Time;tool;training opportunity;transcription factor;Transcriptional Regulation;transcriptome sequencing;triple helix;Work;wound healing

PROJECT_TITLE: Cellular and molecular delineation of pathologic fibroblasts in pulmonary fibrosis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS