NIH_SPENDING_CATS: Bioengineering;Biotechnology;Contraception/Reproduction;Gene Therapy;Genetics;Human Genome;Infertility;Nanotechnology;Nutrition;Orphan Drug;Pediatric;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

PHR: PROJECT NARRATIVE  Hypergonadotropic hypoestrogenic infertility due to ovarian damage is the greatest burden for women suffering from hereditary Classic Galactosemia, an inborn error of metabolism included in the newborn screening programs. Timely diagnosis and introduction of diet have shown to be beneficial, but diet does not prevent ovarian damage, which invariably affects women with this disease. This project aims to develop gene- based therapy targeted to the ovary to prevent or halt the damage cascade and determine the optimal window of opportunity for this treatment.

PI_NAMEs: BERRY, GERARD THOMAS;LAI, KENT  (contact);RUBIO-GOZALBO, ESTELA

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: adeno-associated viral vector;Adolescence;Adolescent;Adolescent and Young Adult;Affect;Alleles;Antibodies;Appearance;Applications Grants;Benign;Biological Assay;Biopolymers;Brain;Cell Line;Cell Physiology;cell type;Cells;Classical galactosemia;Clinical;Complementary DNA;Complex;Complication;curative treatments;Data;design;Development;Diagnosis;Diet;dietary;dietary restriction;Disease;disease diagnosis;DNA delivery;Early Diagnosis;Ectopic Expression;Embryo;Encapsulated;Event;Evolution;experimental study;expression vector;Failure;feasibility testing;Fertility;Fishes;Follicle Stimulating Hormone;Follicle Stimulating Hormone Receptor;Follicular Fluid;folliculogenesis;Functional disorder;Galactose;Galactose Metabolism Pathway;galactose-1-phosphate;Galactosemias;Gene Delivery;Gene Expression Profiling;gene replacement therapy;gene therapy;gene-targeted therapy;General Population;Genes;Genetic;Genetic Diseases;Germ Cells;Gonadal Steroid Hormones;granulosa cell;Hereditary Disease;Histologic;Histology;Hormone Receptor;Human;Human Cell Line;Image;Immunohistochemistry;Impairment;in vitro testing;Inborn Errors of Metabolism;induced pluripotent stem cell;infancy;Infant;Infant formula;Infertility;Inherited;innovative technologies;insight;Life;Ligands;Liver;Modality;Modeling;Molecular;mullerian-inhibiting hormone;nanoparticle;nanoparticle delivery;Neonatal;neonatal period;Neonatal Screening;neonate;nucleic acid-based therapeutics;Online Mendelian Inheritance In Man;Oocytes;Ovarian;ovarian damage;Ovary;Pathogenesis;Pathogenicity;Patients;Pattern;Peptide Fragments;pituitary gonadal axis;plasmid DNA;Play;Polymers;postnatal;Premature Menopause;prenatal;prevent;Puberty;Recombinants;Reproduction;restoration;Reverse Transcriptase Polymerase Chain Reaction;Role;screening program;Severities;Signal Pathway;Signs and Symptoms;single-cell RNA sequencing;Somatic Cell;Specificity;System;targeted treatment;Technology;Testing;Time;Transcriptional Regulation;transcriptome sequencing;Transfection;Tropism;uptake;Variant;Western Blotting;Woman;young adult;Zebrafish

PROJECT_TITLE: Optimal Window of Opportunity for Granulosa Cell Gene Therapy in Galactosemia

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lung;Neurosciences;Pneumonia;Pneumonia and Influenza

ORG_CITY: GREER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NUBAD, LLC

ORG_STATE: SC

PHR: PROJECT NARRATIVE The proposed project presents a strategy for developing novel aminoglycoside therapeutics with reduced ototoxicities with evasion of resistance. Antimicrobial resistance occurs when microorganisms (often infectious bacteria, viruses, and certain parasites) are no longer sensitive to drugs that were previously used to treat them; this is of global concern because it hampers our ability to control infectious disease and increases the costs of health care. In order to combat this world-wide problem, innovative strategies for antibiotic drug design must be implemented. The proposed research describes a strategy for improving the therapeutic index of aminoglycosides by designing novel structures that lower their ototoxicity and evade common resistance pathways.

PI_NAMEs: ARYA, DEV PRIYA (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Abdominal Infection;absorption;Address;ADME Study;Amikacin;aminoglycoside-induced ototoxicity;Aminoglycosides;Anti-Bacterial Agents;anti-microbial drug;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Antimicrobial Resistance;antimicrobial resistant infection;Auditory;Auditory Brainstem Responses;Awareness;Bacillus;Bacteria;Bacterial Infections;Bacterial Pneumonia;Bacterial Proteins;bacterial resistance;Biodistribution;Biological Assay;Biological Availability;Biology;Books;candidate identification;carbapenem resistance;carbapenem-resistant Enterobacteriaceae;Cavia;Cell Wall;Cessation of life;Chemistry;Clinical;Colistin;combat;Communicable Diseases;Complex;Congresses;Coronavirus;cost;Coupled;COVID-19;COVID-19 morbidity;COVID-19 mortality;Creativeness;design;Development;Disease;Dose;Drug Design;Drug Interactions;Drug Kinetics;Drug resistance;Drug Targeting;economic impact;efficacy study;Enterobacteriaceae;Excretory function;extensive drug resistance;Family;Feedback;Fiber;follow-up;Growth;guinea pig model;Hair Cells;Health;Health Care Costs;Hospitals;Human;improved;in vivo;in vivo Model;Infection;Influenza;Influenza A Virus, H1N1 Subtype;inhibitor;innovation;Institute of Medicine (U.S.);Intervention;Intra-abdominal;Klebsiella pneumoniae;Knowledge;L Forms;Lead;Legal patent;Length of Stay;Lethal Dose 50;Libraries;Liver Microsomes;Lung Diseases;Lung infections;Measurement;Medical;Metabolism;method development;Methods;Microbial Biofilms;microorganism;Minimum Inhibitory Concentration measurement;Modeling;Modernization;Modification;mortality;Multi-Drug Resistance;multidisciplinary;Mus;Nosocomial Infections;novel;novel antibiotic class;novel therapeutic intervention;novel therapeutics;Nucleic Acids;Organ Culture Techniques;ototoxicity;pandemic influenza;Parasites;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Pharmacodynamics;Phase;phase 1 study;Pneumonia;Population;pre-clinical;pre-Investigational New Drug meeting;preclinical toxicity;priority pathogen;Proliferating;Protein Biosynthesis;Protocols documentation;Pseudomonas aeruginosa;Rapid screening;rapid technique;rapid test;Rattus;Renal function;Reporting;Research;Resistance;Resistance profile;Ribosomes;Risk;Risk-Benefit Assessment;RNA;RNA Binding;Role;screening;Sensory Hair;Sepsis;Serum;Severe Acute Respiratory Syndrome;Severities;small molecule;Societies;Solid;South Carolina;standard of care;Structure;success;Superbug;Surgeon;synergism;Testing;Therapeutic;Therapeutic Index;Thigh structure;tigecycline;Time;Toxic effect;United States;United States National Academy of Sciences;Universities;Urinary tract infection;Viral;Virus;Work;World Health Organization;Zebrafish

PROJECT_TITLE: Aminoglycosides with reduced ototoxicity


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: TAMPA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative The goal of The Environmental Determinants of Diabetes in the Young Study (TEDDY) is the identification of infectious agents, dietary factors, or other environmental agents, including psychosocial factors which trigger type 1 diabetes (T1D) in genetically susceptible individuals. This project will extend the study to include viral markers. Identification of such factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay or reverse T1D.

PI_NAMEs: KRISCHER, JEFFREY P (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Adherence;Age;Autoantibodies;case control;clinical center;Clinical Investigator;cohort;Cohort Analysis;Collaborations;Communication;Confidentiality of Patient Information;Data;Data Analyses;Data Collection;Data Coordinating Center;data de-identification;Data Management Resources;data quality;data repository;Data Security;Data Set;data sharing;Development;Diabetes Mellitus;Dietary Factors;Disease;Documentation;Educational workshop;Ensure;environmental agent;Evaluation;Florida;follow up assessment;follow-up;Funding;Goals;Health;HLA Antigens;Individual;Infectious Agent;Infectious Diseases Research;Insulin-Dependent Diabetes Mellitus;Laboratories;Literature;Maintenance;Manuals;meetings;Messenger RNA;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;operation;Paper;Participant;Pathogenesis;Performance;Periodicals;Predisposition;Preparation;prevent;primary endpoint;Procedures;Protocols documentation;Psychosocial Factor;Publications;Qualifying;Quality Control;Reporting;repository;Research;Research Personnel;Sampling;Schedule;Secure;Services;Site Visit;Source;Specific qualifier value;study population;symposium;timeline;Training;Universities;Viral Markers;Visit;web site;Work

PROJECT_TITLE: Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Immunotherapy;Nanotechnology;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE This project is relevant to public health because it could make available an effective and safe therapeutic regimen that dramatically increases the response rates of cancer patients to immune checkpoint inhibitors, immunotherapies that have revolutionized cancer therapy because they elicit robust treatment responses in previously untreatable tumors. It will also advance insight into the scientific merit and feasibility of engineering ensemble nanoimmunotherapies by combining biofunctionalized nanoparticle-based photothermal therapy with immune checkpoint inhibition for treating cancer, and the immunological basis for the observed treatment responses. Successful completion of the project will provide the impetus for clinical translation of our nanoimmunotherapy, thereby extending lasting benefits to a larger proportion of cancer patients.

PI_NAMEs: FERNANDES, ROHAN  (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Adjuvant;Agonist;anti-CTLA-4 therapy;anti-CTLA4;anti-PD-1;Antigen Presentation;Antigen-Presenting Cells;Antigens;antitumor effect;calreticulin;Cancer Etiology;cancer immunotherapy;Cancer Patient;cancer therapy;Cells;checkpoint inhibition;childhood cancer mortality;Clinical;clinical translation;Combination immunotherapy;Combined Modality Therapy;Development;Disease;Distal;efficacy evaluation;efficacy testing;Electrostatics;Engineering;Exhibits;HMGB1 gene;Immune;Immune Cell Suppression;Immune checkpoint inhibitor;immune-related adverse events;immunogenic cell death;immunogenicity;Immunologic Adjuvants;Immunologic Memory;Immunologics;Immunotherapy;Impairment;improved;in situ vaccine;In Vitro;in vivo;insight;ipilimumab;Lasers;Malignant Neoplasms;Metastatic Melanoma;Modeling;Molecular;Monitor;mouse model;Mus;Nanoimmunotherapy;nanoparticle;Nanotechnology;neoplastic cell;Neuroblastoma;Nivolumab;novel;novel therapeutic intervention;Oligonucleotides;Oncolytic viruses;particle;patient subsets;Pattern;Phenotype;photothermal therapy;Play;Primary Neoplasm;Prussian blue;Public Health;Radiation therapy;Radiofrequency Interstitial Ablation;Regimen;relapse prevention;response;Role;T cell response;T-Lymphocyte;Testing;Therapeutic;therapy outcome;Toll-like receptors;Treatment Protocols;treatment response;tumor;tumor ablation;Tumor Antigens;tumor eradication;Tumor Escape;Tumor Immunity;tumor progression

PROJECT_TITLE: Engineered Ensemble Nanoimmunotherapies for Cancer


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative Severe defects in the primary cilium cause prenatal lethality while less severe defects result in a variety of diseases including polycystic kidney disease and blindness along with a group of syndromes called the ciliopathies. These syndromes, which include Bardet-Biedl, Meckel Gruber and Jeune Syndromes, often present with cystic kidney disease and blindness along with a variety of symptoms including obesity, mental retardation, and structural birth defects. This proposal seeks to understand the mechanism by which cilia are assembled and function to ultimately drive the identification of a treatment or cure for these diseases.

PI_NAMEs: PAZOUR, GREGORY J (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Adaptor Signaling Protein;Back;Basal cell carcinoma;Binding;Binding Proteins;Biology;Blindness;Carrier Proteins;Cell Nucleus;Cells;Cilia;ciliopathy;Complex;Congenital Abnormality;Coupling;Cystic Kidney Diseases;Data;Defect;Degenerative Disorder;Development;Disease;disorder prevention;Down-Regulation;Dynein ATPase;Endosomes;Environment;Enzymes;Erinaceidae;Etiology;Eukaryota;Event;Excision;extracellular;Functional disorder;Funding;Gene Expression;Homeostasis;human disease;insight;Jeune syndrome;Kinesin;Lead;Ligand Binding;Ligands;Link;Lysine;Malignant Neoplasms;Membrane;Mental Retardation;Microtubules;Monitor;Motor;Movement;Mus;Mutation;Obesity;Organelles;particle;Pathway interactions;pharmacologic;Phenotype;Polycystic Kidney Diseases;prenatal;Process;protein complex;Protein Isoforms;Proteins;receptor;Retrieval;Role;Sensory;Signal Pathway;Signal Transduction;smoothened signaling pathway;Sorting;Structural Congenital Anomalies;Structure;Symptoms;Syndrome;System;targeted treatment;Therapeutic Intervention;Tissues;transcription factor;Ubiquitin;Ubiquitin-Conjugating Enzymes;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Intraflagellar Transport Proteins in Mice

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Rural Health

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: This program will leverage the healthcare, research, and educational strengths of MaineHealth to provide training to medical students who have an interest in a professional career in Maine. Our vision is to increase the number of research-trained physicians, who will then be enabled to improve healthcare innovation across our rural state.

PI_NAMEs: LIAW, LUCY  (contact);THAKARAR, KINNA

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Academic Medical Centers;Address;Adipose tissue;Biology;Biomedical Research;Blood Vessels;Cardiovascular Diseases;Centers of Research Excellence;Clinical;Clinical Research;Clinical Services;clinical translation;Communities;Cystic Fibrosis;Development;Disease;Education;endothelial dysfunction;Environment;Epidemiology;experience;Fellowship;Fellowship Program;Funding;Genetic;Goals;graduate medical education;Health Services Research;Healthcare;Heart Arrest;Heart failure;Hemorrhagic Shock;Infrastructure;Institution;interest;Internal Medicine;Investments;Maine;Medical;Medical center;medical schools;Medical Students;Mentors;Mentorship;Mission;myocardial injury;National Heart, Lung, and Blood Institute;New England;Physicians;Population;programs;Public Health;Request for Proposals;Research;Research Institute;Research Support;Research Training;Residencies;Rural;stem cells;Students;summer research;Training;Training Programs;Translational Research;Trauma;Universities;vascular inflammation;Vision

PROJECT_TITLE: Enhancing research training for Maine Track / Tufts medical students


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: ALBUQUERQUE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: Project Narrative This project's relevance to human health is through direct training of diverse individuals in biomedical science fields and their subsequent strong performance in Ph.D. programs. The scholars we train will enter the biomedical research workforce and contribute to understanding and ameliorating human disease.

PI_NAMEs: MILLER, KELLY  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Academic skills;Academic Training;Address;Administrator;Anxiety;Area;Bachelor's Degree;Biomedical Research;career;Classification;cohort;Collaborations;college;Communication;Communities;community engagement;Credentialing;Data;design;Development;Development Plans;Doctor of Medicine;Doctor of Philosophy;Education;education research;Educational workshop;Electronic Mail;Enrollment;Ensure;Environment;Ethics;Evaluation;experience;Feedback;Follow-Up Studies;Fostering;Goals;Graduate Degree;graduate school;Health;higher education;Hispanic;Hispanic Populations;Hispanic-serving Institution;Human;human disease;improved;Individual;Information Dissemination;Institution;Institutional Policy;Interview;Journals;Laboratory Research;Marketing;Master of Science;meetings;member;Mentors;Minority;Minority Groups;minority student;Motivation;New Mexico;Outcome Assessment;Performance;Personal Growth;Postbaccalaureate;posters;Preparation;Problem Solving;Process;programs;Qualifying;Readiness;Recording of previous events;recruit;Research;Research Activity;Research Project Grants;Research Training;Resources;Scholars Program;Science;Series;Social Interaction;social media;Standardization;student participation;Students;success;Surveys;symposium;Testing;tool;Training;Training Activity;Training Programs;undergraduate student;Underrepresented Populations;Universities;Writing

PROJECT_TITLE: PREP@UNM Competing Renewal

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Mental Health;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Precision Medicine;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative: The Juvenile Myoclonic Epilepsy Connectome Project will use state-of-the-art imaging methods to measure altered connections between brain regions in patients with juvenile myoclonic epilepsy. It is anticipated that these measurements will provide new methods for predicting outcomes and selecting optimal treatments for individuals with juvenile myoclonic epilepsy.

PI_NAMEs: STRUCK, AARON F (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Academic achievement;Accounting;Adolescence;Adolescent;Age;Age of Onset;Anticonvulsants;Attention deficit hyperactivity disorder;autism spectrum disorder;behavior measurement;Behavioral;Behavioral Symptoms;Biological Markers;Brain;Brain region;Child;Chronic;Clinical;Clinical Markers;clinical predictors;Cognitive;Cohort Studies;comorbidity;connectome;cost;Data;Databases;Development;Diagnosis;Disease;Disease Marker;Disease Progression;Drug resistance;Electroencephalography;Epilepsy;epileptiform;experience;Failure;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Generalized Epilepsy;Generalized seizures;Genetic;health care service utilization;Human;Image;Imaging Device;imaging modality;Individual;interest;Intractable Epilepsy;Juvenile Myoclonic Epilepsy;Lead;life span;Link;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mediating;Medical;Mental disorders;Methodology;Methods;Myoclonus;Nature;neurobehavioral;Neurocognitive;Neurodegenerative Disorders;neurodevelopment;Neurologic;Neuropsychology;novel;novel marker;novel strategies;optimal treatments;Outcome;outcome prediction;Participant;Pathogenicity;Patients;Pattern;personalized management;Persons;Pharmaceutical Preparations;predictive marker;predictive modeling;prognostication;prospective;psychiatric comorbidity;psychosocial;psychosocial outcome;quantitative imaging;Recurrence;Refractory;Resolution;Resources;response;Rest;Risk;risk prediction;Scientist;Seizures;Selection for Treatments;Severities;Severity of illness;socioeconomics;Standardization;structural imaging;Structure;Testing;Tonic - clonic seizures;tool;treatment response;Unemployment;United States;Variant

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Genetics;Human Genome;Mental Health;Pediatric;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: Project Narrative The biological embedding of maltreatment may explain the variability mental health outcomes. The proposed research will identify specific genome-wide DNA methylation patterns unique to maltreatment and link those with changes in mental health symptoms across adolescence. This will further the development of clinical risk assessment and prevention approaches for maltreated youth which will be of substantial benefit to population health.

PI_NAMEs: NEGRIFF, SONYA L (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent;Affect;Age;Aging;Animals;Archives;Biological;Biological Aging;Child;Child Abuse and Neglect;childhood adversity;Chronology;clinical development;comparison group;Data;Dependence;depressive symptoms;Development;DNA Methylation;early life adversity;early life stress;Epigenetic Process;Exhibits;experience;Gene Expression;Genes;genome-wide;genomic data;Heterogeneity;Human;indexing;innovation;Investigation;Knowledge;Length;Life Experience;Life Stress;Link;longitudinal design;Longitudinal Studies;maltreatment;Measures;Mediating;Mediation;Mediator;Mental Health;methylation pattern;Modeling;Neighborhoods;Outcome;Outcome Assessment;Outcome Measure;Pattern;population health;Prevention approach;Process;psychosocial;puberty transition;Research;Resolution;Risk Assessment;risk prediction;saliva sample;sample archive;Sampling;Site;Socioeconomic Factors;Statistical Models;symptomatology;Symptoms;telomere;Testing;Time;Trauma;trauma symptom;Youth

PROJECT_TITLE: Linking DNA methylation with child maltreatment and mental health across adolescence

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: IOWA CITY

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: TITLE: Refining the Genetic and Genomic Architecture of Non‐syndromic Orofacial Clefts The long term goal of this study is to identify novel risk loci for orofacial clefts (OFCs) in the African population. This project is inherently transformative and has the potential for far- reaching impact not only in the African population, but also in populations in the United States, Canada, Europe and other societies with multiracial immigration and distributions with persons of African descents. The successful completion of this project will have significant positive impact on strategies designed towards understanding the biological role of identified variants and modification of genetic risk that will reduce the outcome of OFCs.

PI_NAMEs: BUTALI, AZEEZ  (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Adult;Affect;Affinity;Africa;Africa South of the Sahara;African;African ancestry;Alkanesulfonates;Alleles;Architecture;Asian ancestry;Bilateral;Binding;Biological;Birth;Canada;Candidate Disease Gene;candidate identification;Caring;Cell Line;cell type;Cells;Child;Chromatin;chromatin immunoprecipitation;cleft lip and palate;Cleft lip with or without cleft palate;Cleft Palate;clinical practice;Code;Collaborations;cost;Craniofacial Abnormalities;craniofacial development;Data;de novo mutation;design;Disease;Education;effective intervention;Embryo;Embryonic Development;Engineering;Enhancers;Environmental Risk Factor;Enzymes;Ethanol;Etiology;Europe;European;Family;Folic Acid;Gene Frequency;Genes;Genetic;Genetic Risk;Genetic study;genetic variant;genome sequencing;genome wide association study;genome-wide;genome-wide analysis;Genomics;Genotype;Goals;Hepatocyte;HepG2;high risk;Immigration;in vitro Assay;Individual;Infant;Infrastructure;insight;Iowa;Knowledge;Lead;Link;Liver;Measures;Medical;Meta-Analysis;Metabolism;Minor;Modification;MSX1 gene;multi-ethnic;multi-racial;Mutation;National Human Genome Research Institute;Nigerian;novel;orofacial cleft;Outcome;Parents;Pathogenesis;Pathway interactions;Patients;Persons;Phenotype;Population;Predictive Factor;Prevention;proband;promoter;psychologic;Publishing;rare variant;Reporter;Reporting;Research;Risk;risk variant;Role;Single Nucleotide Polymorphism;Societies;Specificity;Steroids;Testing;Tissues;transcription factor;Translating;transmission process;United States;Universities;Untranslated RNA;Variant;Vitamin D;whole genome;Work;Zebrafish

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Heart Disease;Nutrition;Prevention

ORG_CITY: Boulder

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Narrative Aging is associated with the development of vascular dysfunction, which increases the risk for cardiovascular disease. This clinical trial will determine whether a new oral supplement called MitoQ, which reduces the production of damaging reactive oxygen species from mitochondria, can improve vascular function in older adults, and will provide insight into the biological reasons (mechanisms) by which supplementation with MitoQ exerts these benefits. Overall, this research will provide scientific evidence supporting the use of MitoQ for preserving vascular function and decreasing cardiovascular disease risk with aging.

PI_NAMEs: SEALS, DOUGLAS R (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Acute;Adult;Aftercare;age related;Age Years;Aging;aging demography;Antioxidants;Aorta;arterial stiffness;Arteries;Biochemical;Biological;Biological Assay;Biomedical Research;Biopsy;Blood Vessels;brachial artery;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Carotid Arteries;Cause of Death;Cells;Chronic;circulating biomarkers;Clinical;clinical application;Clinical Trials;Crossover Design;design;Development;Disease;Dose;Double-Blind Method;drinking water;effective intervention;Elasticity;Endothelial Cells;endothelial dysfunction;Endothelium;Exhibits;Exposure to;Femur;fitness;Health;High Prevalence;Human;Impairment;improved;in vivo;indexing;Inner mitochondrial membrane;innovation;insight;Laboratories;Link;Lipoprotein (a);Measures;Mediating;men;Mitochondria;mitochondrial fitness;Molecular;Molecular Profiling;Mus;novel;novel strategies;novel therapeutic intervention;old mice;older adult;older men;older women;Oral;oral supplementation;Oxidative Stress;oxidized low density lipoprotein;Phase;Physiologic pulse;Pilot Projects;Placebo Control;Placebos;Plasma;Positioning Attribute;pre-clinical;preservation;Prevalence;Production;Randomized;Reactive Oxygen Species;Research;Research Technics;Risk Reduction;Serum;Site;Subgroup;Supplementation;tonometry;Translating;Translational Research;Translations;treatment duration;ubiquinol;Ultrasonography;Vascular Diseases;Vascular Endothelium;Woman;young adult

PROJECT_TITLE: Mitochondrial-targeted antioxidant supplementation for improving age-related vascular dysfunction in humans

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hematology;Infectious Diseases;Lung;Patient Safety;Rare Diseases;Sepsis

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: NARRATIVE Pancreatitis is a common and potentially lethal and/or debilitating condition for which existing treatment options have shown limited efficacy. Since inflammation is a key driver of disease progression in pancreatitis, we propose to conduct a Phase II randomized clinical trial to establish if a brief course of anti-inflammatory corticosteroids given very early in the acute process will improve key clinical outcomes including illness severity, inflammation and pancreatic injury, hospital and ICU-free days, and death. Successful trial outcomes will set the stage for a larger multi-site Phase III trial and potentially lead to a new and effective treatment option for pancreatitis.

PI_NAMEs: DONNINO, MICHAEL WILLIAM (contact)

PROGRAM_OFFICER_NAME: SERRANO, JOSE

PROJECT_TERMS: Acute;Acute Necrotizing Pancreatitis;acute pancreatitis;Acute Respiratory Distress Syndrome;Adrenal Cortex Hormones;Adverse event;adverse outcome;Anti-Inflammatory Agents;Attenuated;Biological Markers;Blinded;Blood;Case Study;Cessation of life;Clinic;Clinical;clinical practice;Clinical Trials;COVID-19;Critical Care;Critical Illness;cytokine;Data;Deterioration;Disease;Disease Progression;Dose;early phase clinical trial;effective therapy;follow-up;Future;Hospitals;Hour;Hydrocortisone;Hydrocortisone/Placebo;Hyperglycemia;Hypernatremia;improved;improved outcome;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;Interleukin-10;Interleukin-6;Intervention;Intravenous;Length of Stay;Lipase;Measures;Medical;Medicine;mortality;multiorgan injury;novel;Organ;Organ failure;organ injury;Outcome;Pancreatic enzyme;Pancreatic Injury;Pancreatitis;Patients;Phase;Phase II Clinical Trials;phase II trial;phase III trial;Physiological;pilot trial;Placebo Control;placebo group;Placebos;Prevention;primary outcome;Process;Publishing;Quality of Life Assessment;Randomized;randomized trial;randomized, clinical trials;Regimen;Reporting;Research;Respiratory distress;Respiratory Failure;response;Resuscitation;Safety;safety assessment;Sample Size;Scheme;Science;secondary outcome;Sepsis;Series;Serum;Severity of illness;Severity of Illness Index;Shock;side effect;Site;Steroids;Stratification;Subgroup;systemic inflammatory response;Systemic Inflammatory Response Syndrome;Testing;Therapeutic;Therapy trial;Trypsinogen;United States;Validation;Ventilator

PROJECT_TITLE: Corticosteroids to Reduce Inflammation in Severe Pancreatitis (CRISP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The proposed studies here will investigate the mechanisms of adhesion by which the dental caries etiological agent Streptococcus mutans (SM) ensures biofilm formation, colonization and virulence. The outcome of this study will discover common-binding-motif(s), and provide the necessary information for rationally designing methods to prevent SM’s adherence to tooth surface and/or biofilms.

PI_NAMEs: DEIVANAYAGAM, CHAMPION CHRISTDOSS SELVAKUMAR (contact);WU, HUI

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acids;Address;Adherence;Adhesions;Adopted;Affect;Affinity;Animal Model;Antigens;Bacterial Adhesins;Binding;biofilm species;Candida albicans;Child;Collagen;combinatorial;comparative;Complex;Comprehension;Coupled;dental biofilm;Dental caries;Dental Models;Development;Dextrans;dysbiosis;early childhood;Ecology;Ensure;Etiology;Future;Gene Mutation;Genes;genetic manipulation;glucan-binding protein;Glucans;Glucosyltransferases;glycoprotein 340;Goals;Human;Individual;Investigation;Knowledge;Ligands;Maps;Mediating;Membrane Proteins;Methods;Microbe;microbial;Microbial Biofilms;microbial colonization;microorganism;microorganism interaction;Modeling;Molecular;Mutagenesis;mutant;nanomolar;Oral;Oral cavity;oral streptococci;Outcome;Outcome Study;pathogen;Pathogenesis;Pathogenicity;Peptides;Play;polymicrobial disease;Population;Predisposition;prevent;Production;Protein C;Proteins;rational design;Rattus;Repression;Resolution;Rodent Model;Role;saliva secretion;Salivary;Scavenger Receptor Cysteine-Rich Domain;Site;sortase;Streptococcus adhesin;Streptococcus gordonii;Streptococcus mutans;Streptococcus Viridans Group;Structure;Study models;Surface;Therapeutic;tooth surface;Virulence

PROJECT_TITLE: The Structural and Functional Determination of Streptococcus mutans Adherence


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: Narrative Acute emergency healthcare within a rural state varies, with marked disadvantages and poorer outcomes for emergency events occurring in rural areas. This program builds upon Maine Medical Center's exceptional clinical experience and strong basic/translational research program to create a framework for enhancing acute care research throughout our state. We will also address consent and inclusion for research in acute care to increase participation of rural subjects in clinical studies, with the long-term goal of improving acute care outcomes for patients in rural areas.

PI_NAMEs: SAWYER, DOUGLAS B (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Acute;acute care;Address;Adult;Antibiotic Prophylaxis;Antibiotics;Area;Bioethics;care delivery;care systems;career;Caring;Center for Translational Science Activities;Centers of Research Excellence;Childhood;Clinical;clinical care;clinical infrastructure;Clinical Research;cohort;Collaborations;Communities;community engagement;community involvement;community partnership;Consent;Core Facility;Critical Care;design;Development;Disadvantaged;Disparity;disparity reduction;diversity and inclusion;Doctor of Pharmacy;Doctor of Philosophy;Emergency Care;Emergency medical service;Emergency Situation;Encephalopathies;Ensure;Event;experience;Foundations;Funding;Future;Goals;health care disparity;Health Professional;Healthcare Systems;Heart Arrest;Human Subject Research;Hypoxia;immunoregulation;improved;improved outcome;Inflammation;Infrastructure;Injury;innovation;Institution;Intervention;Investigation;Leadership;Learning;life span;Maine;Medical;Medical center;medical specialties;Mentors;Mentorship;Methods;Molecular;neonatal hypoxic-ischemic brain injury;neonate;Neurological outcome;Neurologist;neuroprotection;Newborn Infant;novel;novel therapeutics;Operative Surgical Procedures;Outcome;outreach;palliative;Patient-Focused Outcomes;Patients;Pharmacists;Phase;Physicians;Pilot Projects;Pneumonia;Population;prevent;Preventive;Process;programs;prophylactic;Protocols documentation;Reduce health disparities;Rehabilitation therapy;Research;Research Infrastructure;Research Institute;Research Methodology;Research Personnel;research study;Research Support;Resources;response;Resuscitation;Risk;Rural;rural area;Rural Community;rural disparities;Rural Health;rural health disparities;rural patients;Rural Population;rurality;Scientist;Services;Signal Transduction;Site;Standardization;success;survival outcome;Survivors;synergism;System;Technology;teleconsent;Telemedicine;tertiary care;Testing;Time;tool;Training;Translational Research;translational research program;trauma care;Travel;United States National Institutes of Health;urban area;urgent care;Variant

PROJECT_TITLE: Center of Biomedical Research Excellence in Acute Care Research and Rural Disparities


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rural Health;Social Determinants of Health

PROJECT_TERMS: Acute;acute care;Advisory Committees;Antibiotic Therapy;Area;Basic Science;Bioethics;Biomedical Research;Cardiopulmonary Resuscitation;Cardiovascular system;care outcomes;care systems;career;Caring;Centers of Research Excellence;Clinical;clinical center;Clinical Research;cohort;Collaborations;Communication;community engagement;community engagement process;Community Hospitals;Community Outreach;Consent;Core Facility;design;Development;Discipline;Disparity;disparity reduction;Doctor of Philosophy;Emergency Situation;Ensure;Ethics;Evaluation;Exhibits;experience;Face;Family;Fostering;Funding;Goals;Growth;Health Personnel;Health Services Research;Healthcare;Healthcare Systems;Heart Arrest;Human Subject Research;improved outcome;Inflammatory Response;Infrastructure;innovation;Institution;Investments;Leadership;Learning;Link;Maine;Medical;Medical center;meetings;Mentors;Mentorship;Modeling;Molecular Analysis;National Institute of General Medical Sciences;neonatal encephalopathy;neonate;New England;organizational structure;outcome disparities;outreach;Patients;Physicians;Pilot Projects;Principal Investigator;Process;Program Development;Program Evaluation;programs;prophylactic;Reporting;Research;Research Methodology;Research Personnel;Research Training;Rural;rural area;Rural Community;rural disparities;rural health disparities;rurality;Scientist;Severities;Strategic Planning;Structure;success;synergism;System;Teacher Professional Development;Telemedicine;Translational Research;translational research program;United States National Institutes of Health;urban area;urgent care

PROJECT_TITLE: Administrative and Professional Development Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research

PHR: Suicide risk prediction models are being used by health care systems to guide delivery of suicide prevention interventions, but these prediction models may not accurately identify high-risk patients in racial and ethnic subgroups that are less prevalent or have lower rates of suicide attempt and death. This project will reduce racial and ethnic disparities in suicide risk models by developing methods for prediction model estimation that optimize performance within subgroups, rather than across the whole population, and adjust for misclassification of suicide outcomes. We will also design sample size calculations that evaluate the ability of a prediction study to accurately identify high-risk individuals within racial and ethnic subgroups.

PI_NAMEs: COLEY, REBECCA YATES (contact)

PROGRAM_OFFICER_NAME: WOUHIB, ABERA

PROJECT_TERMS: access disparities;Address;Adopted;Adult;Age;Alaska Native;Algorithms;American Indians;Asian;black patient;Black Populations;Cessation of life;Clinical Data;clinical predictors;Complex;Data;Death Rate;design;Development;Differential Diagnosis;Disparity;Emergency department visit;Ensure;ethnic disparity;Ethnic Origin;Ethnic Population;Evaluation;Event;Funding;Gender Identity;health care availability;health care disparity;health care service utilization;health care settings;health disparity;Health system;Healthcare;Healthcare Systems;high risk;high risk population;Hispanic Populations;improved;innovation;interest;Label;machine learning method;machine learning model;Measurement;Measures;Mental Health;Methods;Modeling;Modification;National Institute of Mental Health;Not Hispanic or Latino;novel;Outcome;outcome prediction;Outpatients;Pacific Islander;Paper;Patient Care;Patients;Pattern;Performance;Persons;Population;predictive modeling;preventive intervention;Primary Care;primary care visit;Procedures;Psychiatry;Race;racial difference;racial disparity;racial population;random forest;recidivism;Records;Research;Research Personnel;response;Risk;Risk Factors;risk prediction;risk prediction model;Sample Size;Sampling;Self-Injurious Behavior;Severity of illness;sexual identity;simulation;social health determinants;Source;Statistical Methods;Stratification;Subgroup;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;treatment pattern;trend;Underserved Population;United States;Visit;Vulnerable Populations;Weight;Work

PROJECT_TITLE: Innovative methods to reduce racial and ethnic disparities in suicide risk prediction

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Services;Patient Safety;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The proposed research is meaningful to public health because it aims to address ongoing gaps in inpatient pediatric safety. This project is directly relevant to NICHD's interests in: describing the epidemiology of inpatient pediatric safety events; studying the strengths and limitations of current methods of error reporting systems; addressing pediatric medication errors; and developing a system to learn from the ongoing evaluation of patient error and adverse event analyses to improve the delivery of care.

PI_NAMEs: BARDACH, NAOMI SHULA (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Address;Admission activity;Adult;Adverse event;attributable mortality;care delivery;Caring;Categories;Cellular Phone;Characteristics;Child;Childhood;Clinical;Communication;County Hospitals;Data;demographics;detection method;Development;Diagnosis;Epidemiology;Evaluation;Event;experience;Family;Family member;Health system;Health Technology;Hematology;hospital readmission;Hospital safety;Hospital Units;Hospitalization;Hospitalized Adolescent;Hospitals;implementation evaluation;implementation framework;implementation strategy;implementation tool;improved;infection rate;innovation;Inpatients;Intensive Care;interest;Interview;Knowledge;Language;Learning;literacy;Medical;Medical Records;Medication Errors;Methods;Modeling;mortality;National Institute of Child Health and Human Development;new technology;Newborn Infant;novel strategies;Oncology;Operative Surgical Procedures;Outcome;Outcomes Research;Participant;patient engagement;patient population;patient safety;Patients;Pediatric epidemiology;pediatric patients;Pediatrics;Persons;Pharmaceutical Preparations;Physicians;pilot test;point of care;Population;prevent;Prevention;Public Health;Publications;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Report (document);Reporting;Research;Safety;safety net;safety study;San Francisco;Social Desirability;Source;System;systematic review;Technology;Testing;Text Messaging;theories;Time;tool;trauma centers;Variant;Work

PROJECT_TITLE: The Family Input for Quality and Safety (FIQS) Study

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Subjective cognitive decline (SCD), or a person’s perception of changes in their cognitive abilities, has been identified as a possible early marker of preclinical Alzheimer’s disease (AD) in non-Hispanic Whites; however, research is lacking about the value of SCD reporting in diverse populations. This study will investigate the associations of self and informant reports of SCD with biomarker profiles of AD and objective cognitive trajectories in Hispanic/Latino older adults living in the United States over 3 years. Learning about the value of SCD to predict biomarker profiles of AD and changes in cognition in older Hispanics/Latinos can help with early detection of individuals at risk for cognitive decline and improve outcomes via preventative interventions.

PI_NAMEs: ZLATAR, ZVINKA ZOE (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Acculturation;Activities of Daily Living;Age;age related;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-Protein;Anxiety;Apolipoprotein E;Biological Markers;blood-based biomarker;California;Clinical;Cognition;Cognitive;cognitive ability;cognitive change;Cognitive deficits;cognitive function;cognitive performance;cognitive testing;cohort;Country;Data;Dementia;Disability prevention;Disabling;Disease;Early Diagnosis;Early identification;Education;Educational Status;Enrollment;ethnic minority;Ethnic Origin;Ethnic Population;experience;Future;Goals;Growth;health literacy;healthy aging;Hispanic;Hispanic Populations;Impaired cognition;improved;improved outcome;Individual;Individual Differences;informant;Language Tests;Latino;Latino Population;Learning;Measurement;Measures;Mediating;Memory;Mental Depression;mild cognitive impairment;Moods;Not Hispanic or Latino;novel;older adult;Participant;Patient Recruitments;Patient Self-Report;Perception;Persons;Population;Population Heterogeneity;pre-clinical;predictive marker;Predictive Value;Prevention;preventive intervention;prospective;Questionnaires;racial population;Recommendation;Reporting;Research;Risk;Risk Marker;Sampling;sex;Site;Spain;Symptoms;Time;United States;Universities;Vision;Work;β-amyloid burden

PROJECT_TITLE: Subjective Cognitive Decline and Objective Cognitive Trajectories in Older Hispanics/Latinos

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Rural Health;Social Determinants of Health

PI_NAMEs: CHESSA, FRANK  (contact)

PROJECT_TERMS: Acute;acute care;Address;Adherence;Aging;Asphyxia;Attitude;Authorization documentation;Awareness;Bioethics;career;Caring;Centers of Research Excellence;Clinical;Clinical Research;Communities;community consultation;community engagement;Consent;design;Disadvantaged;Disclosure;Disparity;Distant;Doctor of Philosophy;Education;eligible participant;Encephalopathies;Enrollment;Ensure;Environment;Ethics;experience;Face;Family;Female;Future;Gender;Geographic Locations;Geography;Health Care Research;Heart Arrest;Hospitals;Hour;human subject;human subject protection;Inequality;Informed Consent;Infrastructure;Institutional Review Boards;Legal;Life;Location;Maine;Medical;Medical center;Medical Research;medical schools;member;Mentors;Neonatal;outreach;participant enrollment;Pathway interactions;Patients;Physicians;preference;Preparation;pressure;Process;prognostication;programs;Protocols documentation;recruit;Regulation;Reporting;Research;research and development;Research Design;Research Personnel;Research Project Grants;Research Training;Resources;Rural;rural area;Rural Community;rural disparities;rural healthcare;Rural Hospitals;rural patients;Rural Population;rural setting;rurality;Scientist;Site;skills;Stroke;Teaching Hospitals;teleconsent;tertiary care;Time;Transportation;Trauma;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;urban area;urban setting

PROJECT_TITLE: Community Engagement, Bioethics and Outreach Core


ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: Project Narrative Relevance: The identification of critical therapeutic targets in MPN cells will have a significant impact on the development of much needed treatments for the 300,000 MPN patients in the U.S. While deregulated JAK2 activity has been identified as an important factor that contributes to MPN formation and has been targeted by small molecule inhibitors, these drugs have had very limited success in patients. This proposal will investigate a potential Achilles’ heel of JAK2 inhibitor-treated cells as a target for novel strategies to improve MPN therapeutics, as well as interrogate unknown molecular details of the molecular biology of MPNs and response to JAK2 inhibitors.

PI_NAMEs: REUTHER, GARY W (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Acute Myelocytic Leukemia;Affect;associated symptom;Automobile Driving;Biochemical;Biological;Biology;Blood;Blood coagulation;Bone marrow failure;Cancer Center;Cause of Death;cell growth;Cell Line;Cell Survival;Cells;Climacteric;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;curative treatments;Data;Development;Disease;Disease remission;drug development;Drug resistance;effective therapy;Environment;experience;experimental study;Exposure to;FDA approved;Genetic;genetic manipulation;Glues;Goals;Hematological Disease;Hematopoietic Neoplasms;improved;Induced Mutation;Inferior;inhibitor;inhibitor therapy;innovation;interferon therapy;JAK2 gene;Knowledge;Laboratories;Lead;leukemia;loss of function;Maintenance;MAP Kinase Gene;Mediating;Modeling;Molecular;Molecular Biology;mouse model;Mutation;Myeloproliferative disease;neoplasm therapy;Neoplasms;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Outcome;Pathway Analysis;Patients;Persons;Pharmaceutical Preparations;Philadelphia Chromosome;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotyrosine;Play;prevent;Protein Tyrosine Kinase;Proteins;Proteomics;PTPN11 gene;Qualifying;Regulation;Remission Induction;Research;Resistance;Resistance development;response;RNA Interference;Role;Signal Transduction;small molecule inhibitor;Stem cell transplant;success;Symptoms;synergism;targeted treatment;Testing;Therapeutic;therapeutic target;therapeutically effective;thrombotic complications;transcriptome sequencing;tumor progression

PROJECT_TITLE: Targeting altered phosphatase-dependent signaling to overcome the inefficacy of targeted therapy in myeloproliferative neoplasms

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE This study is likely to result in a feasible, effective, and cost-effective strategy for the sustainment of PBIS with mental health supports in under-resourced urban schools. Linking PBIS with state-of-the-art mental health supports and well-trained school personnel will likely lead to improvement and sustainment of student mental health and academic engagement.

PI_NAMEs: EIRALDI, RICARDO B (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;Administrator;Anxiety Disorders;Behavior Therapy;burnout;Child;Clinical effectiveness;cluster randomized design;Consultations;coping;cost effective;cost effectiveness;Data;Dedications;Disease;Dissemination and Implementation;educational atmosphere;Evidence based practice;experience;Friends;Goals;group intervention;Health Benefit;health training;Human Resources;hybrid type 2 trial;implementation fidelity;implementation outcomes;implementation research;improved;Interactive Systems Framework;Intervention;Interview;Life;Link;Mediating;Mediator;Mental disorders;Mental Health;Mental Health Services;Methods;Modeling;Outcome;Participant;Perception;Phase;Process;Professional counselor;programs;Public Health;Randomized;Remote Consultation;Research;Resources;Risk;Safety;school district;Schools;Series;service delivery;Severities;Site;Structure;Students;Supervision;Symptoms;Training;training opportunity;Training Support;urban school

PROJECT_TITLE: Sustainment of Mental Health Supports in Under-Resourced Urban Schools

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-M(04)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: Boston

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: Project narrative Chemotherapy is the standard of care for triple-negative breast cancer, however up to 25% of patients who receive this treatment will suffer metastatic recurrence within five years. The extracellular matrix is a major component of the tumor microenvironment, which provides structure and support to our tissues, which is known to drive invasion and metastasis. The goal of this project is to investigate how the extracellular matrix contributes to chemoresistance and chemotherapy-induced metastasis.

PI_NAMEs: OUDIN, MADELEINE JULIE (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Adipocytes;Adjuvant Chemotherapy;Affect;Aftercare;Automobile Driving;Breast Cancer Cell;Breast Cancer Patient;Cancer Burden;Caspase;Cathepsins B;cell motility;Cell secretion;cell type;Cessation of life;Chemoresistance;chemotherapy;Clinical;Collagen;Collagen Type IV;Crosslinker;Data;Development;Drug resistance;Endothelial Cells;Environment;Excision;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Fibronectins;Gene Expression Profile;Glycoproteins;Goals;Human;improved;In Vitro;in vivo;Individual;insight;Invaded;Laminin;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Metastasis Induction;Metastatic/Recurrent;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel;Operative Surgical Procedures;Paclitaxel;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Play;Population;prevent;Process;Property;Proteins;Proteoglycan;Recurrence;Relapse;Research;Residual Cancers;Resistance;response;Role;Sampling;Signal Transduction;standard of care;Structural Protein;Structure;Testing;Therapeutic;therapy outcome;three-dimensional modeling;Tissues;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Tissue;Up-Regulation

PROJECT_TITLE: Investigating mechanisms of chemoresistance in triple-negative breast cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Rural Health;Social Determinants of Health

PI_NAMEs: MAY, TERESA  (contact)

PROJECT_TERMS: Accident and Emergency department;acute care;Admission activity;Affect;Attention;Benchmarking;biomedical referral center;Cardiopulmonary Bypass;cardiovascular disorder risk;care systems;Caring;Cause of Death;Centers of Research Excellence;Clinical;Clinical Trials;Collaborations;Communication;community center;Complex;Country;Critical Care;Data;Data Analyses;Data Sources;design;Development;Development Plans;Disparity;disparity reduction;Emergency medical service;Emergency response;Epidemiology;experience;Face;Future;geographic disparity;Goals;Guidelines;health difference;Healthcare Systems;Heart Arrest;Hospitalization;Hospitals;implementation science;improved;improved outcome;Injury;Intensive Care Units;Intervention;Lead;learning community;Location;Maine;Managed Care;Measures;Medical emergency;Mentorship;Methods;mortality;Myocardial Infarction;North America;organ injury;out-of-hospital cardiac arrest;Outcome;outcome disparities;Pathway interactions;Patient Care;Patient Triage;Patient-Focused Outcomes;Patients;Physiologic pulse;Policies;Positioning Attribute;Protocols documentation;Provider;Qualitative Research;Recommendation;Reporting;Research;Research Personnel;Resources;Resuscitation;Risk Adjustment;Rural;rural area;rural disparities;Rural Health;rural health disparities;rural patients;rurality;socioeconomic disparity;Standardization;standardized care;Subgroup;Surveys;System;tertiary care;Testing;Time;Training;Travel;Treatment Protocols;treatment strategy;trend;urban area;Weather;Work

PROJECT_TITLE: Reducing Rural Disparities in Cardiac Arrest Outcomes by Standardization of Care


NIH_SPENDING_CATS: Antimicrobial Resistance;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Infectious Diseases;Lung;Neurosciences;Pneumonia;Pneumonia and Influenza;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: GAGNON, DAVID  (contact)

PROJECT_TERMS: acute care;Address;Adenosine;Affect;Amoxicillin;Anti-Bacterial Agents;Anti-Inflammatory Agents;Antibiotic Prophylaxis;Antibiotic Resistance;Antibiotics;Antiinflammatory Effect;antimicrobial;Antimicrobial Effect;Bacteremia;Bacterial Drug Resistance;bacterial resistance;bactericide;Biological;Biological Response Modifier Therapy;Blinded;Brain Injuries;Cardiopulmonary Resuscitation;career;Caring;Ceftriaxone;Cell Separation;Centers of Research Excellence;Cephalosporins;Clavulanate;Clinical;Clinical Data;Clinical Pharmacists;Clinical Trials;Collaborations;Coma;Communities;Critical Care;cytokine;Data;Down-Regulation;early onset;Enrollment;Ensure;Evaluation;experience;Feces;Functional disorder;functional improvement;Generations;Genotype;Goals;Heart Arrest;heart rhythm;immunoregulation;improved;improved outcome;Inflammation;Inflammatory;Infrastructure;Intervention;Link;Lung infections;Maine;Mediating;Medical center;member;Mentors;metagenomic sequencing;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;natural hypothermia;Neurological outcome;neuroprotection;Neurosciences;novel;out-of-hospital cardiac arrest;Outcome;patient population;Patients;Pharmacodynamics;Pharmacotherapy;Pharmacy facility;Placebo Control;placebo controlled trial;Placebos;Pneumonia;pneumonia treatment;Pragmatic clinical trial;Pre-Clinical Model;Predisposition;prevent;Production;programs;prophylactic;Prophylactic treatment;prospective;Randomized;Reporting;Research;Research Personnel;residence;Resistance;resistance gene;resistome;respiratory examination;Risk;Rural Community;rural disparities;Safety;Sampling;Sepsis;Series;Signal Transduction;Sputum;Structure;Survivors;Syndrome;systemic inflammatory response;T-Cell Activation;T-Lymphocyte;Temperature;Testing;Therapeutic;Work

PROJECT_TITLE: Ceftriaxone Immunomodulation and Antimicrobial Effects After Cardiac Arrest


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Biotechnology;Genetics;Human Genome;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative  Most neurobehavioral diseases emerge at different life stages, and progress in a different pattern in males and females, but fundamental knowledge is lacking regarding when and where sex alters neural development. This project establishes sex-biasing effects of sex hormones and sex chromosomes on localized brain regions across the entire brain at specific times of life, and investigates cellular and molecular mechanisms operating in a sex-specific manner at salient sites of sexual differentiation. Mechanistic information developed in an animal model will be translated to humans using novel high-throughput analysis of patterns of sex differences in brain that have common development across species.

PI_NAMEs: ARNOLD, ARTHUR P (contact);LERCH, JASON P.;MACKENZIE-GRAHAM, ALLAN JAMES

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Acrylamides;Address;Adolescent;Affect;Age;age difference;age related;analysis pipeline;Anatomy;Animal Model;Area;Attention;Automobile Driving;Autopsy;Biological;Biology;Brain;Brain imaging;brain magnetic resonance imaging;Brain Mapping;Brain region;Cell Size;cell type;Cells;cohort;Collaborations;computerized tools;Coupling;Data Set;density;Development;Disease;Disproportionately impacts women;Dissection;dosage;Eating Disorders;Etiology;Female;Foundations;Genes;Genetic Models;Genomics;Genotype;Gonadal Hormones;Gonadal Steroid Hormones;Gonadal structure;Health;high throughput analysis;Histocompatibility;Homologous Gene;Hormonal;Hormones;Human;human model;Hydrogels;Image;Impairment;in vivo;Individual;innovation;interdisciplinary collaboration;Investigation;Kallmann Syndrome;Knowledge;Language;Language Development;Life;Lipids;longitudinal analysis;male;Maps;Measures;Methods;Modeling;Molecular;Mood Disorders;Motor;motor control;mouse model;Mus;Nervous System Disorder;Neuroanatomy;neurobehavioral;Neurobiology;neurodevelopment;neuroimaging;novel;Outcome;Pathologic;Pathway interactions;Patients;Pattern;Ploidies;Population;protective effect;Resolution;Risk;Role;Scanning;sex;Sex Bias;sex chromosome aneuploidy;Sex Chromosomes;Sex Differences;Sex Differentiation;Sex Factors;Signal Transduction;single cell genomics;single cell sequencing;single-cell RNA sequencing;Site;Social Development;Social Functioning;spatiotemporal;Specific qualifier value;Stereotyping;Testing;Tissue Sample;Translating;Trisomy;United States National Institutes of Health;Variant;Work;Y Chromosome

PROJECT_TITLE: Coupling neuroimaging with CLARITY and single cell genomics to dissect sex differences in the developing brain

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Neurosciences;Rural Health;Social Determinants of Health

PI_NAMEs: SEDER, DAVID B. (contact)

PROJECT_TERMS: Acute;acute care;Adenosine;Adverse effects;Affect;Anti-Inflammatory Agents;Blood flow;Blood Vessels;Brain;Cardiopulmonary Resuscitation;career;cell injury;Cell Physiology;Cell Separation;Cells;Centers of Research Excellence;Cerebral Edema;Clinical;clinical phenotype;Clinical Research;Development;diversity and inclusion;Elements;Emergency Care;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;Event;experience;Feedback;Functional disorder;Future;Generations;Grouping;Heart Arrest;Heart Injuries;Heterogeneity;Hour;Human;Hypoxic-Ischemic Brain Injury;Immune;Immune response;immunoregulation;Impairment;improved;improved outcome;Infarction;Inflammation;Inflammatory;Inflammatory Response;Injury;Intervention Trial;Ischemia;Knowledge;Laboratories;Lead;Lymphocyte;Lymphocyte Count;Lymphopenia;Mediating;Mediation;Medicine;Mentorship;Molecular;molecular phenotype;Myeloid Cells;Myocardial dysfunction;Names;Natural regeneration;Nervous System Trauma;Neurological outcome;Neurons;neuroprotection;neutrophil;Neutrophil Activation;novel;Organ;Organ failure;Outcome;Pathologic;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Peripheral;Phagocytosis;Phenotype;Physicians;Population;prevent;Production;programs;Reactive Oxygen Species;Recovery;regional difference;repaired;Reperfusion Injury;Research;response;Resuscitation;Risk;rural area;rural disparities;Scientist;Signal Transduction;skills;survival outcome;Survivors;Syndrome;Testing;Time;Tissues;TNF gene;Translational Research;Variant;Work

PROJECT_TITLE: Adenosinergic Signaling in the Immunoinflammatory Response After Cardiac Arrest


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Lung;Lung Cancer;Patient Safety;Prevention;Primary Health Care

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Screening for lung cancer reduces lung cancer mortality but fewer than 4% of eligible Americans get screened, and lung cancer remains the leading cause of cancer death in the United States. mPATH-Lung is an innovative digital outreach program that identifies patients who qualify for lung cancer screening and helps them get screened. This project will determine how mPATH-Lung affects patients’ screening decisions and their completion of screening, potentially reducing the number of people who die from lung cancer.

PI_NAMEs: MILLER, DAVID P (contact)

PROGRAM_OFFICER_NAME: VILLALOBOS, AUBREY VAN KIRK

PROJECT_TERMS: Address;Affect;American;Appointment;Awareness;Behavior;Benefits and Risks;Cancer Etiology;Catchment Area;Cessation of life;Chest;chest computed tomography;Clinic;Colorectal Cancer;Data;Decision Aid;Decision Making;demographics;design;digital;digital intervention;Disease;Dose;Education;Electronic Health Record;Electronic Mail;Electronics;Eligibility Determination;empowerment;Enrollment;Ensure;Exercise;former smoker;future implementation;Goals;Guidelines;Health;Health Personnel;Health system;Health Technology;high risk;implementation outcomes;Individual;innovation;Intention;Internet;Intervention;Interview;Knowledge;Lung;lung cancer screening;lung health;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medicare;Methods;Modeling;Morbidity - disease rate;mortality;Online Systems;Outpatients;outreach;outreach program;Participant;patient engagement;patient portal;Patient risk;patient screening;Patient Selection;Patient-Centered Care;Patients;Persons;primary care patient;primary care provider;primary outcome;Procedures;programs;Provider;Qualifying;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Risk;Risk Factors;routine screening;Schedule;screening;Screening for cancer;Screening Result;secondary outcome;shared decision making;social;Structure;Surveys;System;Text Messaging;theories;Time;United States;United States Preventative Services Task Force;Visit;X-Ray Computed Tomography

PROJECT_TITLE: A Personalized Digital Outreach Intervention for Lung Cancer Screening

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Dr. Pardue’s research program is centered on developing life-changing treatments for veterans with vision loss. Her pre-clinical research in the areas of neuroprotective treatments for retinal disease, detection and treatment of diabetic retinopathy, and mechanisms for myopia or near-sightedness have formed the basis for 3 translational studies to human patients (retinal prosthetics, diabetic retinopathy, and neuroprotection therapies). Dr. Pardue’s dual appointment between the VA and GaTech and her research interests create novel opportunities to develop ground-breaking treatments that can preserve or halt vision loss.

PI_NAMEs: PARDUE, MACHELLE T. (contact)

PROJECT_TERMS: Age;age related;American;Appointment;Area;Award;Basic Science;bench to bedside;Biomedical Engineering;Blindness;career;career development;Climacteric;Clinic;Collaborations;Communities;Detection;Development;Diabetes Mellitus;Diabetic Retinopathy;Disease;Dopamine;Early Diagnosis;Early Intervention;Early treatment;editorial;Education;Educational process of instructing;Exercise;Eye;Faculty;field study;Foundations;Functional disorder;Funding;Future;Goals;graduate student;Growth;Healthcare;Human;IACUC;Imaging technology;improved;Institution;instructor;interest;International;Journals;Laboratories;Laboratory Finding;Leadership;lectures;Light;Lighting;Medical;Medicine;member;Mentors;Mentorship;Methods;Mission;Molecular;Myopia;neuroprotection;Neurosciences;new technology;novel;novel therapeutic intervention;Ophthalmology;Pathology;Patients;Physical Exercise;Population;Positioning Attribute;Postdoctoral Fellow;pre-clinical research;preclinical study;preservation;Privatization;Process;programs;Publications;Quality of life;rehabilitation strategy;Research;research and development;Research Personnel;research study;Research Support;Resources;Retina;Retinal Degeneration;Retinal Diseases;retinal prosthesis;Role;Science;Scientist;screening;Signal Transduction;Silver;stem;Students;Study Section;success;symposium;System;Tissues;Translating;translational study;Translations;undergraduate student;United States National Institutes of Health;Veterans;Vision;vision science;Visual System;Woman

PROJECT_TITLE: RR&D Research Career Scientist Award Application

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Bioengineering;Osteoporosis

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative  The objective of this R01 application is to bridge the critical knowledge gap on the cellular mechanisms and mechanical consequences of modeling- and remodeling-based bone formation in response to anabolic treatment and withdrawal, and to provide essential therapeutic implications of modeling-based bone formation on novel design of cyclic administration regimen of anabolic agents with intervening anti-resorptive agents.

PI_NAMEs: LIU, XIAOWEI SHERRY (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Adult;Anabolic Agents;Antibodies;bone;bone loss;bone mass;Bone remodeling;Bone Resorption;bone strength;Bone structure;Bone Surface;Bone Tissue;Chronic;Clinical;Collagen;Coupled;Data;Deposition;design;Development;Elasticity;Hardness;Heterogeneity;Image;Image Analysis;imaging platform;improved;innovation;insight;Knowledge;Length;life span;mechanical properties;Mechanics;mineralization;Minerals;Modeling;Modulus;novel;novel therapeutics;Osteoblasts;Osteoclasts;Osteogenesis;Osteoporosis;Ovariectomy;parathyroid hormone-related protein;Periodicity;Predisposition;PTH gene;Rattus;recruit;regenerative;Regimen;Research Project Grants;Resistance;response;Sequential Treatment;Site;Skeleton;standard care;Structure;Structure-Activity Relationship;Testing;Therapeutic;Time;Tissues;treatment duration;treatment effect;Treatment Efficacy;treatment optimization;Treatment Protocols;treatment strategy;Withdrawal

PROJECT_TITLE: Leveraging modeling-based bone formation for osteoporosis treatment

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ORG_NAME: MAINEHEALTH

PI_NAMEs: CRAIG, ALEXA  (contact)

PROJECT_TERMS: Absence Epilepsy;acute care;Address;adverse outcome;Birth;Brain;Brain Injuries;care outcomes;Caring;Centers of Research Excellence;Cessation of life;Childhood;Clinical;Clinical Research;Clinical Trials;Collaborations;Community Hospitals;Consent;Consult;Consultations;Critical Care;Critical Illness;Data;Disadvantaged;disparity reduction;Edema;effectiveness testing;Electroencephalography;Eligibility Determination;excitotoxicity;Exclusion;experience;Future;Genetic Transcription;Goals;health care availability;health care disparity;Hospital Mortality;Hospitals;Hour;implementation science;improved;Individual;Informed Consent;Interview;Legal patent;Life;Limb structure;Location;Magnetic Resonance Imaging;Maine;member;mental state;Mentorship;metabolic rate;Movement;Muscle Tonus;natural hypothermia;Neonatal;neonatal encephalopathy;neonate;Neonatology;neuroinflammation;Neurologic;Neurologist;neuroprotection;New England;Newborn Infant;obstetric services;Outcome;outcome disparities;Parents;Patient Selection;Pediatric Neurology;Pediatrics;Pilot Projects;Predictive Value;prevent;Primary Care Physician;Process;programs;Qualitative Methods;Reflex action;Research;Research Personnel;Resuscitation;Risk;Rural;rural area;Rural Community;rural disparities;rural healthcare;Secure;Seizures;standard of care;Standardization;sucking;teleconsultation;Telemedicine;tertiary care;Therapeutic;Time;Trauma

PROJECT_TITLE: Telemedicine to Reduce Disparities in the Identification and Treatment of Neonatal Encephalopathy


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Chronic pain after injuries is a major medical problem for Veterans and members of the general population. Chronic pain in the setting of traumatic brain injury (TBI) is particularly prevalent and difficult to treat. Patients suffering TBI and additional injuries (polytrauma) are even more likely to experience chronic pain. Commonly employed treatments such as the use of opioids and NSAIDS are highly problematic in Veterans with TBI. On the other hand, recent evidence suggests that persistent pain after TBI results from damage to endogenous pain control mechanisms residing in the brainstem. Thus we may be able to reduce or even prevent pain after TBI by augmenting the actions damaged neural circuitry. This project will pursue this goal using multiple approaches in a well-characterized rodent TBI and polytrauma models. At the conclusion of the project we expect to be in position to translate our findings to clinical populations using agents similar or identical to those optimized for use in the animal subjects.

PI_NAMEs: CLARK, DAVID J. (contact)

PROJECT_TERMS: Adrenergic Agents;Affect;Animal Model;Animals;antinociception;Anxiety;Area;behavior test;behavioral outcome;Brain Injuries;Brain Stem;Cells;Chronic;Chronic Brain Injury;Chronic disability;chronic pain;Clinical;cognitive change;Cognitive deficits;combat;Complement;Data;Degenerative polyarthritis;design;designer receptors exclusively activated by designer drugs;Development;Diabetic Neuropathies;disability;Dorsal;efficacy evaluation;Emotional;Equipment;Evaluation;experience;Fiber;Fibromyalgia;Functional disorder;Gene Expression;General Population;Genes;Genetic;Goals;Grant;healing;Hindlimb;Histologic;Human;human model;Human Resources;Immunohistochemistry;inhibitor;Injury;insight;Laboratories;Lateral;Link;Liquid substance;locus ceruleus structure;Measures;Medical;member;Memory;Microinjections;midbrain central gray substance;Modeling;Molecular;Molecular Biology;Multiple Trauma;neural circuit;neuroinflammation;Neuronal Plasticity;Neurons;neuropathology;Neuropsychology;Neurotoxins;Nociception;Non-Steroidal Anti-Inflammatory Agents;noradrenergic;Norepinephrine;Opioid;Outcome;Pain;Pain Clinics;pain inhibition;Pain management;Pathway interactions;Patients;Percussion;Peripheral;Persistent pain;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Population;Positioning Attribute;pre-clinical;preclinical study;Preclinical Testing;prevent;Process;Productivity;Rattus;Reagent;receptor;Regulation;Regulatory Pathway;Resources;reuptake;Rodent;Role;Selective Serotonin Reuptake Inhibitor;Sensory;Serotonin;serotonin 7 receptor;Signal Transduction;soft tissue;Soft Tissue Injuries;Source;Spinal;Spinal Cord;Spinal cord posterior horn;Structure;Surgical incisions;synaptic function;System;targeted treatment;TBI Patients;Testing;Tibial Fractures;Time;Tissues;tool;Toxin;Translating;translational study;Trauma;Trauma patient;Traumatic Brain Injury;Veterans;War

PROJECT_TITLE: Traumatic Brain Injury and Endogenous Pain Modulation

STUDY_SECTION: RRDA

STUDY_SECTION_NAME: Spinal Cord Injury/Disorders & Neuropathic Pain[RRDA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative The Ubiquitin System is an intense research area with great promise for the improvement of human health. In addition to its critical role in normal physiology, malfunctions in ubiquitin biology have been implicated as a contributing factor in the causation of many illnesses as diverse as diabetes, cancer, and Alzheimer's disease. This proposal will develop new mass spectrometry-based technologies for sample multiplexing specifically tailored to chemical biology workflows to define small molecule-protein interactions which can be used as precursors for therapeutic interventions. 0

PI_NAMEs: GYGI, STEVEN P (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Acute;Address;Alzheimer's Disease;Amino Acids;application programming interface;Area;Attention;Binding;Biological;Biological Assay;Biology;bropirimine;Categories;Cell Physiology;Cells;Cellular Assay;Chemicals;Chemistry;Complex;Computer software;Computers;Custom;Cyclins;Cysteine;Databases;Decision Making;Defect;Degradation Pathway;design;desthiobiotin;Development;Diabetes Mellitus;Disease;Enzymes;Etiology;Event;Exclusion;Experimental Designs;follow-up;Fractionation;Genomics;Glues;Goals;Grant;Health;Human;improved;innovation;instrument;Intervention;Isotope Labeling;Isotopes;Label;Libraries;Ligase;Lysine;Malignant Neoplasms;Maps;mass spectrometer;Mass Spectrum Analysis;Measures;Mediating;member;Methods;Modification;Molecular;multicatalytic endopeptidase complex;Neurodegenerative Disorders;next generation;non-Native;novel;Pathway interactions;peptide A;Peptide Library;Peptides;Permeability;Pharmaceutical Preparations;pharmacologic;Physiology;Process;Property;protein degradation;Proteins;Proteome;Proteomics;Reaction;Reagent;recruit;Research;Role;Sampling;Scanning;screening;small molecule;synthetic peptide;System;Technology;Therapeutic;Therapeutic Intervention;Time;tool;Ubiquitin;ubiquitin isopeptidase;ubiquitin ligase;ubiquitin-protein ligase;Work

PROJECT_TITLE: New Sample Multiplexing Technologies to Identify Chemical Probes and Illuminate Ubiquitin Biology

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: This research aims to prevent cognitive decline in older African Americans with diabetes and Mild Cognitive Impairment. If successful, this research will preserve independence and health in an underserved population and reduce racial health disparities. These outcomes have major public health importance.

PI_NAMEs: ROVNER, BARRY W. (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: active control;Address;African American population;Alzheimer's Disease;American;Area;Awareness;Behavior Therapy;Behavioral;Belief;Blood Vessels;Caring;Cerebrum;Cognition;Cognitive;Cognitive deficits;Communication;Community Health Aides;comorbidity;comparative efficacy;Data Set;Dementia;dementia burden;density;Diabetes Mellitus;diabetes mellitus nursing;Double-Blind Method;Education;Effectiveness;efficacy evaluation;efficacy testing;enhanced care;executive function;experience;Genotype;glycemic control;Glycosylated hemoglobin A;Goals;Health;health belief;health equity;high risk;high risk population;Home;human old age (65+);Impaired cognition;improved;Incidence;innovation;Language;Measures;Mediating;Medical;Memory;Microvascular Dysfunction;mild cognitive impairment;Nerve Degeneration;Neurodegenerative Disorders;Neuropsychology;Non-Insulin-Dependent Diabetes Mellitus;Nursing Faculty;Optical Coherence Tomography;Outcome;Participant;Patient Recruitments;Persons;Pharmaceutical Preparations;Phase;Physicians;preservation;prevent;Prevention strategy;Preventive treatment;Primary Care Physician;primary care practice;primary outcome;processing speed;progression risk;Proxy;Public Health;Race;racial health disparity;randomized, clinical trials;Randomized, Controlled Trials;recruit;Renal function;Research;Retina;retina blood vessel structure;retinal nerve fiber layer;Risk;Risk Reduction;Secondary Prevention;Self Care;Site;telehealth;Testing;Thick;treatment as usual;treatment comparison;treatment effect;Treatment Efficacy;treatment group;treatment optimization;Uncertainty;Underserved Population;verbal;Verbal Learning;Vision;Visit;Visuospatial

PROJECT_TITLE: Health Beliefs, Glycemic Control, and Preventing Cognitive Decline in African Americans with Diabetes and Mild Cognitive Impairment: A Randomized Clinical Trial


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Kidney Disease;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Activation of the immune system to eliminate tumor cells is an exciting approach to cancer therapy, but only a portion of patients respond to these interventions. Clear cell Renal Cell Carcinomas are variably responsive to treatment with immunotherapy, and we have found that the tumor microenvironment of this cancer may restrict metabolic pathways essential for effector T cell function. This study will examine mechanisms and potential approaches to overcome these metabolic barriers to anti-tumor immunity to improve immunotherapy.

PI_NAMEs: RATHMELL, JEFFREY C. (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: 3-Dimensional;Address;Affect;antagonist;cancer cell;Cancer Etiology;cancer therapy;cancer type;CD4 Positive T Lymphocytes;CD80 gene;CD8B1 gene;Cell Physiology;Cell Shape;cell type;Cells;Cellularity;Clear cell renal cell carcinoma;Complex;Consumption;CRISPR screen;CTLA4 gene;cytokine;Dissociation;effector T cell;Enzymes;Genes;Genetic;Glucose;glucose metabolism;glucose uptake;Glutamate-Ammonia Ligase;Glutamates;Glutaminase;Glutamine;Glycolysis;high dimensionality;histone methylation;Human;Hypoxia;Immune;immune activation;immune checkpoint blockade;Immune system;Immunity;Immunosuppression;Immunotherapy;Impairment;improved;In Vitro;in vivo;Inflammatory;Intercellular Fluid;Intervention;kidney cortex;Longitudinal cohort;Lymphocyte Function;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Modeling;Mus;neoplastic cell;novel therapeutics;Nutrient;Nutrient availability;Operative Surgical Procedures;Organoids;Pathway interactions;Patients;PD-1/PD-L1;peripheral blood;PIK3CG gene;Play;Population;Positron-Emission Tomography;Primary Neoplasm;Process;Production;Proteins;Radiolabeled;Resources;response;restraint;Role;Sampling;Shapes;Signal Transduction;standard of care;T cell differentiation;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Tracer;tumor;Tumor Immunity;tumor metabolism;tumor microenvironment;Tumor Promotion;Tumor Suppressor Proteins;Tumor Tissue;Tumor-associated macrophages;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;uptake;Waste Products

PROJECT_TITLE: Metabolic barriers to T cell activation in clear cell renal cell carcinoma

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


PHR: OVERALL PROJECT NARRATIVE The overarching hypothesis of our PPG states that early life stress (ELS), such as household dysfunction, neglect, sexual or physical abuse, economic hardship, and exposure to violence induces immune cell activation leading to vascular dysfunction with increased hypertension risk and CVD risk that are exacerbated by later life stressors or moderated by resilience/protective factors. This PPG with both basic science and clinical projects utilizes a synergistic and integrative approach translating concepts from animal models to humans with our major goal being to inform prevention and intervention strategies to mitigate future CVD risk in individuals exposed to ELS. Our PPG will address two critical barriers to fulfill our goal: 1) need for ELS-specific in-depth mechanistic and translational studies; and, 2) identify modifiable protective factors that can mitigate ELS-induced CVD risk.

PI_NAMEs: POLLOCK, JENNIFER S (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: abuse neglect;Address;Adolescence;Adolescent;Adult;Animal Model;Basic Science;Bioinformatics;Biometry;Blood Pressure;blood pressure control;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Central Nervous System;Child;Child Rearing;circadian;Clinic;Clinical;clinically relevant;Collaborations;cost;Data;Data Analytics;data management;Diastolic blood pressure;Diet;disorder risk;early life stress;Economics;effective therapy;emerging adult;Endothelium;Ensure;epigenome;Europe;experience;Exposure to;Functional disorder;Future;Goals;Grant;gut microbiome;Health;healthcare burden;Heart Rate;Household;Human;Hypertension;immune activation;Individual;Inflammation;Inflammation Mediators;Inflammatory;insight;Intervention;late life;Life;Life Stress;lifestyle factors;Macrophage;Manuscripts;Measurement;Mediating;Mentors;metabolome;Mission;Molecular;monocyte;multiple omics;National Heart, Lung, and Blood Institute;neural network;North America;novel;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Phenotype;physical abuse;Physical activity;Physiologic pulse;Prevention;Prevention strategy;Program Research Project Grants;programs;prospective;protective factors;Psychological Stress;Publications;Recording of previous events;Reproducibility;resilience;Risk;Risk Factors;Rodent;Rodent Model;Sampling;Sexual abuse;Specimen;Stressful Event;stressor;Structure;synergism;System;Techniques;Technology;Telemetry;Temperature;transcriptome;Translating;translational potential;translational study;Translations;traumatic event;Vascular Diseases;Vascular Endothelium;Vascular resistance;violence exposure;Work

PROJECT_TITLE: Early Life Stress Induced Mechanisms of Cardiovascular Disease Risk and Resilience

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(OA)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

PHR: ADMINISTRATIVE AND DATA ANALYTICS CORE A NARRATIVE The primary goal of the Administrative and Data Analytics Core is to enhance the research environment and infrastructure in pursuit of building on the strong synergy between Project Leaders, Core Directors, and all investigators to ensure cost effective management and integration of the goals of the PPG. The major functions of the Administrative Core include fostering scientific progress and coordination, promoting professional development, facilitating administrative and budgetary requirements, a biorepository with sample and data management as well as providing statistical and informatics resources, in order to accomplish the scientific mission of the PPG.

PROJECT_TERMS: Advisory Committees;Alabama;biobank;Bioinformatics;biological specimen archives;Biometry;Blood Vessels;built environment;Businesses;cardiovascular disorder risk;Clinical;Collaborations;Committee Members;Communication;Communities;Consultations;Cost Effective Management;Data;Data Analytics;Data Collection;data dissemination;data handling;data management;Data Management Resources;Dedications;design;Development;Documentation;early life stress;Ensure;Environment;Experimental Designs;Faculty;Fostering;Funding Mechanisms;Future;Goals;high standard;Hypertension;improved;Individual;Infrastructure;Institution;Iowa;Maintenance;Manuscripts;meetings;member;Mentors;Mission;Modification;National Heart, Lung, and Blood Institute;next generation;novel strategies;Office of Administrative Management;Policies;Postdoctoral Fellow;power analysis;pre-doctoral;Procedures;Productivity;Program Research Project Grants;programs;Progress Reports;Publications;Records;repository;Reproducibility;Research;Research Personnel;resilience;Resource Informatics;Resources;Risk;Sampling;Schedule;Scientific Advances and Accomplishments;Scientist;Services;Standardization;synergism;Training;Translational Research;Travel;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative and Data Analytics Core A

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project narrative: This project utilizes a combination of the most advanced biochemical, biophysical, and structural techniques to investigate mechanisms of Arp2/3 complex inhibition by Arpin and Coronins. A wide coverage of studies will reveal the mechanistic structure-function relationship that underpins inhibition, a critical component in Arp2/3 complex regulation that controls cell motility, tissue development, and muscle contraction. Mutations in Arp2/3 complex and its regulatory proteins have been linked to cancer metastasis, cardiomyopathies and vascular diseases, and the expected outcome is a better understanding of the mechanisms of inhibition that should inform strategies for treatment.

PI_NAMEs: FREGOSO, FRED ERICK (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TITLE: Regulation of Actin Polymerization Through Inhibition of Arp2/3 Complex by Arpin and Coronin


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

PHR: CARDIOVASCULAR PHENOTYPING CORE B NARRATIVE The Program Project focuses on elucidating mechanisms by which stress early in life contributes to the serious health problem of cardiovascular risk later in life. The Cardiovascular Phenotyping Core will be critical for providing individual projects within the Program Project expertise and support services regarding: 1) 24-hour blood pressure analysis in rodent models; 2) ambulatory and clinic blood pressure measurements and validation in human participants; and 3) pulse wave velocity and pulse wave analysis assessments in human subjects.

PI_NAMEs: POLLOCK, DAVID M (contact)

PROJECT_TERMS: Aliquot;Ambulatory Blood Pressure Monitoring;Animal Model;Area;biobank;Blood Pressure;blood pressure variability;Blood specimen;Blood Vessels;cardiovascular disorder risk;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cells;Chronic;circadian;Clinic;Computer software;Data;data acquisition;Data Analyses;Data Storage and Retrieval;early life stress;Electronic Mail;Ensure;experience;Frequencies;Goals;Guidelines;Health;Heart Rate;heart rate variability;Hour;Human;Human Resources;human subject;in vivo;Individual;Life;Measurement;Measures;meetings;Methods;Monitor;monocyte;Motor Activity;multiple omics;Outcome;Participant;Pattern;Periodicity;peripheral blood;Peripheral Blood Mononuclear Cell;Phase;Phenotype;Physicians;Physiologic pulse;Plasma;Play;Procedures;programs;Quality Control;remote location;Reproducibility;Research Personnel;resilience;Resources;Rodent;Rodent Model;Role;Rural Community;Sampling;Scientist;Services;Statistical Data Interpretation;Stress;Structure;Supervision;synergism;Telemetry;Temperature;Time;Training;ultrasound;Validation;Work

PROJECT_TITLE: Cardiovascular Phenotyping Core B


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Neurosciences;Prevention;Rehabilitation;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This double-masked randomized controlled trial will leverage the NCI National Community Oncology Research Program (NCI NCORP) and NCI National Clinical Trials Network (NCTN) sites to conduct the first national, full- scale test of a computerized cognitive training program (BrainHQ) against a computerized active attention control program to improve self-reported (perceived) and objective (performance) cognitive functioning as well as examine its impact on other real-world, everyday outcomes in breast cancer survivors with cancer and cancer treatment-related cognitive impairment. Positive or negative findings about this easily accessible therapeutic treatment option will help provide evidence to guide clinicians’ recommendations and survivors’ treatment selections for managing this prevalent, persistent, disruptive, and often debilitating problem.

PI_NAMEs: GANZ, PATRICIA A.;MCDONALD, BRENNA C;VON AH, DIANE MARIE (contact)

PROGRAM_OFFICER_NAME: SCHWEPPE, CATHERINE ANN

PROJECT_TERMS: Address;Aftercare;Age;aging related;Attention;attentional control;base;Brain;Breast Cancer survivor;Cancer Survivor;cancer therapy;cancer-related cognitive impairment;chemotherapy;Clinical;Clinical Oncology;cognitive change;Cognitive deficits;cognitive function;cognitive performance;cognitive training;Communities;Community Clinical Oncology Program;computerized;Consent;Control Groups;Data;design;Division of Cancer Prevention;efficacy evaluation;efficacy testing;efficacy trial;Eligibility Determination;evidence base;experience;follow-up;Goals;Health;health related quality of life;High Prevalence;Home;hormone therapy;Impaired cognition;improved;interest;Intervention;Letters;Life;Location;Malignant Neoplasms;Masks;Measures;Memory;Methodology;Minority;Modeling;National Clinical Trials Network;Negative Finding;neural network;Neurocognitive;Neuronal Plasticity;Neurons;Neuropsychological Tests;Neuropsychology;Oncology;Outcome;Patient Self-Report;Peer Review;Perception;Performance;Pilot Projects;post intervention;primary outcome;processing speed;Productivity;programs;Randomized;Randomized, Controlled Trials;Recommendation;remote assessment;remote delivery;Reporting;Research;Research Priority;Sampling;Science;secondary outcome;Site;Survivors;Testing;Therapeutic;therapy design;Time;Training Programs;Translations;Treatment-Related Cancer;Waiting Lists;Work

PROJECT_TITLE: Cognitive Training for Cancer-related Cognitive Impairment: A Multi-Center Randomized Controlled Trial

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE Although tobacco smoke exposure is the most important risk factor for lung cancer inherited genetic factors also play a role as shown by many family and genome wide association studies. The proposed studies will detect novel rare genetic factors, examine interactions between smoking history and the rare genetic factors and evaluate the impact on the cellular phenotypes of these mutations.

PI_NAMEs: AMOS, CHRISTOPHER I.;LIU, YANHONG  (contact);PINNEY, SUSAN MENGEL

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: Affect;Biological;Cancer Etiology;Cancer Family;cancer risk;Cell Line;Cellular biology;Collection;CRISPR/Cas technology;Data;data resource;Development;DNA Library;Environmental Exposure;Epidermal Growth Factor Receptor;Etiology;exome sequencing;Family;Family Cancer History;Family history of;Family member;Family Study;Frequencies;Generations;Genes;Genetic;genetic analysis;genetic epidemiology;genetic linkage analysis;genetic selection;genetic variant;genome wide association study;Genotype;Germ Lines;Goals;Grant;high risk;high risk population;indexing;Individual;Inherited;insight;Joints;Malignant neoplasm of lung;Malignant Neoplasms;member;Modality;mortality;Mutation;next generation;novel;PARK2 gene;Participant;Pathway interactions;Penetrance;Phenotype;Population;Predisposition;Prevention;Prevention Measures;proband;rare variant;RB1 gene;Recording of previous events;Research;Resources;Risk;Risk Factors;risk variant;Role;Sampling;Sampling Studies;screening;Second Degree Relative;Smoking;Smoking Behavior;smoking exposure;Smoking History;Specimen;targeted sequencing;TCF3 gene;Testing;tobacco smoke exposure;Tobacco smoking behavior;Toxic Environmental Substances;TP53 gene;tumorigenesis;Update;Variant

PROJECT_TITLE: Sequencing Familial Lung Cancer

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]