NIH_SPENDING_CATS: Genetics

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE IgE-mediated mast cell activation is widely thought to be detrimental in venom allergy and other allergic disorders, but recent research indicates that mast cells and IgE paradoxically can contribute to protective immunity against the toxicity of honeybee and other animal venoms. This proposal seeks to identify and characterize genetic modifiers that differentiate detrimental vs. beneficial functions of mast cell- or IgE/mast cell-associated immune responses in venom allergy. This project may uncover novel regulatory pathways that can be harnessed to ameliorate or prevent mast cell activation induced by insect venoms, medicines or foods.

PI_NAMEs: GALLI, STEPHEN JOSEPH (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Accounting;Affinity;Allergens;Allergic;Allergic Disease;Allergic Reaction;Anaphylaxis;Animals;Antigens;Bacteria;Binding;Biological Models;Candidate Disease Gene;cardiovascular collapse;CD4 Positive T Lymphocytes;Cell Degranulation;Cell Physiology;Cell secretion;Cells;Cessation of life;chemokine;Clinical;confocal imaging;Coupled;CRISPR/Cas technology;crosslink;cytokine;Cytoplasmic Granules;Development;Disease;Dose;experience;experimental study;Exposure to;Food;functional genomics;Genes;Genetic;genetic analysis;genetic linkage analysis;Genetic Variation;genomic locus;Growth Factor;Host Defense;Human;Hymenoptera;Hypersensitivity;IgE;IgE Receptors;IgG1;Immune;Immune response;Immunity;improved;In Vitro;Individual;Inflammation;Inflammation Mediators;Insect Sting;Insecta;Life;Lipids;Maps;mast cell;Measures;Mediating;Mediator;Medicine;Modeling;Modification;Mus;novel;Outcome;Parasites;Passive Cutaneous Anaphylaxis;pathogenic bacteria;Pathology;Peptide Hydrolases;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Predisposition;prevent;Prevention approach;Probability;Production;Proliferating;Quantitative Trait Loci;Reaction;Regulatory Pathway;Research;Resistance;Resolution;response;Role;screening;Severities;Shock;Signs and Symptoms;Snake Venoms;Staphylococcus aureus;Sting Injury;Strongyloides;System;technology platform;Tissues;Toxic effect;trait;Variant;Venoms;Work;Zebrafish

PROJECT_TITLE: Characterization of innate and IgE-mediated mast cell functions in honeybee venom allergy using Collaborative Cross mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(57)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE A significant risk factor for the development of breast cancer is age as evidenced by the peak incidence at age 70 and older, which are largely estrogen receptor (ER) positive disease. ER+ breast cancers in the elderly are both clinically and biologically distinct from ER+ tumors in younger patients suggesting that these patients may benefit from different therapies. The proposed study will utilize molecular techniques and breast cancer models including matched patient tumor and plasma samples, patient derived organoids, and syngeneic rat models to examine the unique microenvironment and altered ER signaling in the elderly that could ultimately lead to improved diagnosis, outcomes, and therapeutic options.

PI_NAMEs: CARLETON, NEIL  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Adverse effects;Age;age related;Age Years;aged;Aging;aging population;Anti-Inflammatory Agents;Behavior;Biological;Biology;Breast;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;Breast Cancer Risk Factor;Cancer Etiology;career;chemokine;Chronic;Clinical;Clinical Trials;cohort;cost;cytokine;Cytokine Receptors;Deimplementation;Development;Diagnosis;Disease;Disease-Free Survival;DNA Methylation;Elderly;Epigenetic Process;epigenomics;ESR1 gene;Estradiol;Estrogen receptor positive;Estrogen Receptors;Estrogens;Estrone;estrophilin;Exhibits;Foundations;Future;Gene Expression;Genomics;Goals;Growth;Guidelines;hormone therapy;improved;Incidence;Inflammation;Inflammatory;inflammatory marker;inflammatory modulation;innovation;Interleukin-6;Intervention;Investigation;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Methylation;middle age;Modeling;Molecular;neoplastic cell;new therapeutic target;NF-kappa B;older patient;Organoids;Outcome;overtreatment;Pathogenesis;Pathway interactions;patient population;Patients;permissiveness;Persons;Pharmaceutical Preparations;pharmacologic;Physicians;Physiological;Plasma;Population;Radiation therapy;Rattus;Receptor Activation;Receptor Signaling;Recommendation;Recurrence;Research Training;Risk;Risk Factors;Role;Sampling;Scientist;Sentinel Lymph Node Biopsy;Signal Transduction;spectrograph;standard care;STAT3 gene;Techniques;Testing;Therapeutic;Training;transcriptome sequencing;transcriptomics;Translational Research;treatment guidelines;tumor;tumor growth;tumor microenvironment;tumor progression;Woman;Women's mortality

PROJECT_TITLE: Promotion of ER+ Breast Cancer Progression in the Elderly


ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative The proposed studies are relevant to public health because discovery of novel drugs to treat pancreatic cancer represents a significant unmet need in oncology. This work is thus relevant to NIH’s mission to develop impactful new treatment for pancreatic cancer, a disease with no cure.

PI_NAMEs: NEAMATI, NOURI  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Ablation;analog;antagonist;Antimycin A;Bioenergetics;Biomass;Bromouridine sequencing;cancer cell;Cancer cell line;cancer stem cell;Cell Hypoxia;Cell Line;Cells;chemotherapy;Clinical;clinical candidate;clinical development;Clinical Research;cohort;cytotoxicity;Data;Dependence;design;Disease;DNA Repair Gene;Dose;Down-Regulation;Drug Combinations;Drug Delivery Systems;Drug or chemical Tissue Distribution;Drug resistance;efficacy evaluation;Equilibrium;exome sequencing;FDA approved;Future;gemcitabine;Generations;Genes;Genetically Engineered Mouse;Glycolysis;Growth;Human;Image;Immune checkpoint inhibitor;in vivo;inhibitor;innovation;KRAS2 gene;Lead;lead optimization;Malignant neoplasm of pancreas;Mass Spectrum Analysis;Mediating;Metformin;Mission;Mitochondria;Modeling;multiple omics;Mus;Mutate;nanomolar;Neoplasm Metastasis;novel;novel therapeutics;Null Lymphocytes;Oligomycins;Oncology;Oral;Organ;overexpression;Oxidation-Reduction;Oxidative Phosphorylation;Oxygen Consumption;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;patient subsets;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Phosphorylation Inhibition;Play;preclinical development;Production;Prognosis;Proliferating;Proteomics;PTEN gene;Public Health;Resistance;response;Role;Rotenone;Safety;Series;standard of care;SWI/SNF Family Complex;synergism;Testing;Therapeutic;three dimensional cell culture;tool;Toxic effect;transcriptome sequencing;Transgenic Mice;tumor initiation;tumor progression;Tumor Tissue;Tumor-Associated Process;Tyrosine Kinase Inhibitor;United States National Institutes of Health;Work

PROJECT_TITLE: Preclinical Development of First-in-Class NDUFS7 Antagonists for the Treatment of Pancreatic Cancer


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: Columbus

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE  The present proposal aims to improve cochlear implant outcomes for candidates with residual hearing. These hearing remnants often pose a barrier for potential candidates. Consistent preservation and subsequent ipsilateral electric acoustic stimulation will help to make this technology availale to more patients suffering from substantial levels of hearing loss.

PI_NAMEs: ADUNKA, OLIVER FRANZ (contact);ORTMANN, AMANDA JUDITH

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustic Stimulation;Acoustics;Address;Algorithms;arm;Auditory;Biological Markers;Clinical;clinical practice;Cochlea;Cochlear implant procedure;Cochlear Implants;design;Ear;Electrocochleographies;Electrodes;Electrophysiology (science);Eligibility Determination;Enrollment;evidence base;Feedback;functional status;Goals;Hearing;Hearing Aids;hearing impairment;hearing preservation;Implant;implantation;Implanted Electrodes;improved;improved outcome;Intraoperative Monitoring;Ipsilateral;Knowledge;Literature;Measures;Methods;Monitor;Music;new technology;Noise;Operative Surgical Procedures;Outcome;Outcome Measure;Patients;Perception;Performance;Positioning Attribute;Postoperative Period;preservation;Probability;Protocols documentation;Quality of life;Randomized;Reporting;Residual state;Secondary to;Speech Perception;Surgeon;System;Technology;Time;Trauma

PROJECT_TITLE: Clinical Utility of Residual Hearing in the Cochlear Implant Ear


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Proper control of DNA methylation is essential for normal embryo development, alterations of which underlie a broad range of structural birth defects. We discovered specific functions for TET enzymes to keep DNA unmethylated during early stages of embryogenesis and also a previously unstudied protein called QSER1 that cooperates with TETs to regulate early developmental control genes. We propose genetic and biochemical experiments to determine the relative contributions of these factors to DNA methylation dynamics in order to understand fundamental mechanisms regulating early stages of organogenesis.

PI_NAMEs: EVANS, TODD R (contact);HUANGFU, DANWEI

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Aberrant DNA Methylation;Aging;Animal Model;ATAC-seq;Binding;Binding Proteins;Biochemical;Biological Assay;Biological Models;Cell Differentiation process;Cells;Chromatin;chromatin modification;Chromatin Structure;Collaborations;Complex;Congenital Abnormality;Coronary Arteriosclerosis;CRISPR screen;Data;demethylation;Development;Developmental Gene;directed differentiation;Disease;DNA;DNA Methylation;DNA methylation profiling;DNA Methylation Regulation;Embryonic Development;Endoderm;Enhancers;Enzymes;Epiblast;Epigenetic Process;epigenomics;Excision;experimental study;Family;Family member;Fragile X Syndrome;Gene Expression;Genes;Genetic;genetic analysis;Genetic Transcription;genetic variant;genome-wide;Germ Layers;Goals;Histones;Human;human embryonic stem cell;human stem cells;Hydroxylation;immunodeficiency-centromeric instability-facial anomalies syndrome;In Situ Hybridization;Knowledge;Larva;Link;Malignant Neoplasms;member;Mesoderm;Methylation;methylome;Modeling;Mus;mutant;Mutation;neural;Neurodegenerative Disorders;Neuroectoderm;novel;Nucleic Acid Regulatory Sequences;Organ;Organogenesis;paralogous gene;Pathway interactions;Pattern;Phenotype;Play;Productivity;progenitor;programs;promoter;protein complex;Protein Truncation;Proteins;Proteomics;Publishing;Reader;Regulation;Regulator Genes;Regulatory Element;Reporter;Repression;Research Personnel;Role;Science;Seckel syndrome;single-cell RNA sequencing;Site;Specific qualifier value;stem cell fate;stem cell fate specification;stem cell model;stem cells;Structural Congenital Anomalies;Structure;Syndrome;Testing;tool;Validation;Vertebrates;Zebrafish

PROJECT_TITLE: Regulation of DNA methylation by TETs and QSER1

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

PHR: Project narrative Gene therapy is a highly promising approach for the treatment of retinal blinding diseases, however, safe, efficient, and controlled gene delivery to the retina, particularly in the macula, remains a significant challenge. This project will develop an innovative biocompatible retinal-adhesive gel loaded with next-generation viral vectors as a new approach for safe and efficient targeting of photoreceptors and RPE via focal epiretinal gene delivery. As proof of concept, this novel gene therapy delivery system will be used to treat two well- characterized canine models of human retinal degeneration diseases: NPHP5-LCA and RPE65-LCA2.

PI_NAMEs: BELTRAN, WILLIAM A.;BYRNE, LEAH ;DILEO, MORGAN ;SAHEL, JOSE-ALAIN  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;adeno-associated viral vector;adenovirus mediated delivery;Adhesives;Adverse effects;Affect;Alleles;Animal Model;Area;Biocompatible Materials;biomaterial compatibility;canine model;Canis familiaris;cell type;Cells;ciliopathy;Clinic;Clinical;Clinical Trials;Complex;Data;delivery vehicle;Dependovirus;Development;Development Plans;Diffusion;Disease;disease phenotype;dosage;Dose;effective therapy;Engineering;Ensure;expectation;fovea centralis;Future;Gel;gene augmentation therapy;Gene Delivery;gene therapy;Genes;Human;human model;Image;Immune response;Implant;implant compatibility;improved;in vivo;Inflammation;Inflammatory;inherited retinal degeneration;Injectable;Injections;innovation;intravitreal injection;Leber's amaurosis;Leber's Hereditary Optic Neuropathy;Libraries;macula;manufacture;Marketing;Mediating;member;Methods;Mutation;Nephronophthisis;neuroprotection;next generation;nonhuman primate;novel;novel strategies;Operative Surgical Procedures;optogenetics;Outcome;Outcome Study;particle;patient population;Performance;Phenotype;Photoreceptors;Polymers;prevent;Procedures;programs;Property;Research;Research Personnel;Retina;Retinal Degeneration;Retinal Diseases;Retinal gene therapy;Retinal Photoreceptors;RPE65 protein;single-cell RNA sequencing;skills;Specificity;Structure of retinal pigment epithelium;subretinal injection;success;Surface;System;Technology;Testing;Therapeutic;Time;Toxic effect;Toxicity Tests;transgene expression;Translations;Validation;Variant;vector;Viral;Viral load measurement;Viral Vector;Virus Diseases;viscoelasticity

PROJECT_TITLE: Retinal-adhesive thermoresponsive gel for AAV-mediated gene delivery to the outer retina


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Depression;Genetics;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Alzheimer’s disease is a rapidly growing public health issue, but the role of subcortical structures in disease initiation and progression are not adequately understood. By combining electrophysiology, transcriptomics, and morphological analysis, we aim to identify adaptations that occur in single dopamine neurons in a model of Alzheimer’s disease (AD). The results will lay the groundwork for future studies identifying novel therapeutic targets for preventing or slowing AD related deficits.

PI_NAMEs: BLANKENSHIP, HARRIS  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 3xTg-AD mouse;Action Potentials;Affect;Age;Age Months;aged;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amygdaloid structure;Amyloid;Anhedonia;Animal Model;Animals;Area;aspirate;Atlases;Award;base;biocytin;Bioinformatics;Brain;Brain region;career;Cells;Classification;Cognition;Cognitive;comorbid depression;comorbidity;Confocal Microscopy;Coupled;Data;Dementia;Deposition;Development;Disease;dopamine replacement therapy;Dopaminergic Cell;dopaminergic neuron;efficacious treatment;Electrophysiology (science);experimental study;Fluorescence;functional decline;Functional disorder;Functional impairment;Future;Gene Expression Profile;Generations;Genes;Goals;Heterogeneity;Hippocampus;Human;Image;Immunoassay;Immunohistochemistry;Impaired cognition;Impairment;improved;Individual;insight;Intervention;Ion Channel;Knowledge;Label;Length;Link;Measures;Medial;memory encoding;Memory impairment;Mental Depression;Midbrain structure;Molecular;Molecular Biology;molecular phenotype;Mood Disorders;Morphology;mouse model;multimodality;Mus;mutant;Neurites;Neurodegenerative Disorders;Neurofibrillary Tangles;neuronal cell body;Neurons;new therapeutic target;novel;Nucleus Accumbens;Operative Surgical Procedures;patch clamp;patch sequencing;Pathologic;Pathology;Pathway interactions;Physiological;Potassium Channel;Predisposition;Prevalence;prevent;Process;Property;protein aggregation;Proteins;Public Health;Publishing;reconstruction;Reporting;Research;reward processing;Role;Scheme;Senile Plaques;sex;Short-Term Memory;Signal Transduction;single cell sequencing;skills;Slice;spatiotemporal;Specificity;Structure;Synapses;System;tau aggregation;tau Proteins;Time;timeline;Tissue-Specific Gene Expression;Training;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Organisms;Ventral Tegmental Area

PROJECT_TITLE: Multimodal ventral tegmental area decrements in a mouse Alzheimer's model


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: CLEVELAND

ORG_DEPT: PEDIATRICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE: Diabetes technology is advancing at a rapid pace, but large disparities in the use of continuous glucose monitors, insulin pumps, and automated insulin delivery systems exist for Non-Hispanic Black patients with type 1 diabetes. There are many barriers to technology use in minority patients, and culturally-sensitive, effective solutions are needed. Based on feedback from patients and families with lived experience as minorities with diabetes, we will develop and evaluate an intervention utilizing 1) remote monitoring of technology use with diabetes management assistance and 2) personal support by a community health worker who will serve as diabetes technology coach to address barriers to sustained technology use.

PI_NAMEs: MACLEISH, SARAH A (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Acute;Address;Adoption;Attitude;black patient;Black race;Caring;Characteristics;Child;Childhood;Childhood diabetes;Collaborations;Communities;Community Health Aides;Continuous Glucose Monitor;Control Groups;dashboard;Data;data sharing;Devices;diabetes distress;diabetes management;Diabetes Mellitus;Diagnosis;Disparity;disparity reduction;Educational Technology;effectiveness evaluation;Effectiveness of Interventions;Electronic Mail;experience;Family;Feedback;Frequencies;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;group intervention;health care disparity;Healthcare;high risk;implementation evaluation;implementation intervention;improved;Insulin;insulin dependent diabetes mellitus onset;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Insurance;Intervention;Interview;Letters;Lived experience;Manufacturer;Measures;Microvascular Dysfunction;Minority;minority patient;Monitor;mortality;Not Hispanic or Latino;novel;Outcome Measure;Participant;Patients;Perception;prevent;primary outcome;Protocols documentation;Provider;Pump;Race;randomized, controlled study;Recommendation;recruit;remote monitoring;Resources;response;Risk;Role;secondary outcome;Self Efficacy;smartphone application;socioeconomics;standard of care;System;Technology;Telephone;Time;treatment arm;treatment as usual;Triage;Trust;young adult;Youth

PROJECT_TITLE: Glucose Optimization Through Technology Assisted Management (GO TEAM!):Use of a diabetes dashboard and community health worker to decrease disparities in technology use in pediatric T1D


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Patient Safety;Pediatric;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Adolescent idiopathic scoliosis affects up to 3% of all children with >20,000 children undergoing major spinal fusion surgery annually at a cost of $5 billion. Identification of patients at risk for scoliosis curve progression or serious comorbidities is needed to implement prevention strategies but is hindered by lack of data from underrepresented minorities, including African Americans. In this project, we are setting a new research direction for our competitive renewal by proposing to study scoliosis in diverse populations and to improve genetic variant interpretation for all patients using high-throughput functional genomics.

PI_NAMEs: DOBBS, MATTHEW BARRETT;GURNETT, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 16p11.2;Adolescent;Affect;African American;African American population;African ancestry;Age;Aortic Aneurysm;Benign;Biological Assay;Cardiac;Child;Chromosomes;Classification;Clinical;clinical application;clinical practice;Code;cohort;Collagen;Collagen Gene;comorbidity;cost;Data;Data Set;Disease;Distal;diverse data;Early Diagnosis;Electronic Health Record;Ethnic Origin;European ancestry;exome;FBN1;Frequencies;functional genomics;Funding;FURIN gene;gene discovery;Genes;Genetic;genetic disorder diagnosis;genetic risk factor;Genetic study;genetic testing;genetic variant;genome-wide;Goals;health care disparity;high throughput screening;Human Genetics;Idiopathic scoliosis;improved;Individual;Knowledge;Laboratories;Legal patent;Life;life span;Link;MADH3 gene;Methodology;Methods;Modeling;Multicenter Studies;Musculoskeletal;mutation screening;Neurologic;novel;Older Population;Operative Surgical Procedures;Pain;Paper;parent project;Participant;Pathogenesis;Pathogenicity;Pathway interactions;patient population;Patient Recruitments;Patients;personalized diagnostics;personalized medicine;Persons;Phenotype;Population Heterogeneity;precision medicine;prevent;Prevention strategy;Progress Reports;protein function;public health relevance;Publishing;rare variant;recruit;Reporting;Research;Risk;Risk Factors;risk variant;scoliosis;Speed;Spinal Fusion;Surgical complication;tertiary care;Testing;Time;Transforming Growth Factor beta;treatment strategy;Underrepresented Minority;Underserved Population;Variant;variant of unknown significance;whole genome;Work;Zebrafish

PROJECT_TITLE: Genetic risk factors for severe scoliosis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: The goal of this proposal is to identify the impact of fixational eye movements on neural representations in visual cortex in the central visual field. Over 9 million Americans have central vision loss from age-related macular degeneration. Results from this proposal will build a fundamental understanding of how retinal signals from the fovea are processed by visual cortex during natural visual behavior.

PI_NAMEs: YATES, JACOB L (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: active vision;Address;Age related macular degeneration;American;area striata;awake;Behavior;Behavioral;Blindness;Brain;Callithrix;career;career development;central visual field;Code;Cognitive;Computer Models;computerized tools;Custom;Data;Data Set;data-driven model;design;Development;Development Plans;Disease;Ensure;Esthesia;extrastriate;extrastriate visual cortex;Eye;Eye Movements;flexibility;Foundations;fovea centralis;Frequencies;Funding;generative models;Goals;Grant;Human;Image;improved;interest;Laboratories;lens;Machine Learning;Measurement;Measures;Mentors;Modeling;Modernization;Monkeys;Motion;neural;neural model;neuromechanism;Neurons;neurophysiology;new technology;novel;Outcome;Peripheral;Phase;Physiology;Population;Positioning Attribute;Primates;Process;professor;receptive field;Recovery;repaired;Research;Resolution;response;Retina;Retinal Diseases;retinal imaging;Role;Saccades;sample fixation;Sampling;sensor;Series;Signal Transduction;skills;spatial vision;spatiotemporal;Statistical Models;statistics;System;Techniques;Testing;tool;Training;Universities;V1 neuron;V4 neuron;ventral visual stream;Vision;Visual;Visual Acuity;Visual attention;Visual Cortex;Visual Fields;visual information;visual neuroscience;Visual Pathways;visual processing;visual tracking;Work

PROJECT_TITLE: Neural mechanisms of active vision in the fovea


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: TEMPE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative The proposed research is relevant to public health because it aims to improve encapsulated cell survival, a major barrier to translating immunosuppression-free islet transplantation to the wider insulin-dependent diabetic population. It also aims to provide a monitoring tool for encapsulated cell health. This project is relevant to NIH’s mission as it focuses on restoring native insulin signaling to type 1 diabetes patients, with the potential to eliminate secondary complications of diabetes which impact hundreds of thousands of Americans per year.

PI_NAMEs: KODIBAGKAR, VIKRAM D.;WEAVER, JESSICA DIANE (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Address;Allogenic;American;Cell Density;Cell Physiology;Cell Survival;Cell Transplantation;Cells;Chronic;Clinic;Clinical;clinical efficacy;Complications of Diabetes Mellitus;Computer Models;Containment;Coupled;design;Development;Device Designs;Device or Instrument Development;Devices;diabetes risk;diabetic;diabetic patient;diabetic rat;Diffusion;Elements;Encapsulated;Evaluation;experimental study;fabrication;Finite Element Analysis;Geometry;graft function;Graft Survival;Health;Hydrogels;Immune system;Immunosuppression;improved;in silico;In Vitro;in vitro testing;in vivo;in vivo evaluation;in vivo Model;infection risk;Insulin;insulin signaling;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans Transplantation;Label;Location;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Mission;Modeling;Monitor;Morbidity - disease rate;mouse model;Mus;non-invasive monitor;novel;Organoids;Oxygen;Oxygen saturation measurement;Patients;Performance;Population;preclinical efficacy;predictive modeling;Procedures;Process;Protocols documentation;Protons;Public Health;rational design;Rattus;Regimen;Replacement Therapy;Reporter;Research;Risk;Rodent Model;Safety;scale up;Siloxanes;Site;Spatial Distribution;spatiotemporal;success;Surface;Techniques;Testing;Time;tissue oxygenation;Tissues;tool;Translating;translational potential;Translations;Transplantation;type I diabetic;United States National Institutes of Health;Validation;Vascularization;vasculogenesis;Vasculogenic;Work

PROJECT_TITLE: Optimizing macroencapsulation devices for islet transplantation via magnetic resonance oximetry

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The sensitive period for phonetic learning between 6-12 months is one of the earliest milestones in language acquisition as the speech learning outcome of this period can predict individual language skills up to 6 years of age. The proposed project significantly extends the existing literature which only studied typically developing infants (i.e., Low-Risk), and focuses on infants with a family history of developmental language disorder (i.e., High-Risk). Understanding whether High-Risk infants already exhibit altered neural processes of speech during the sensitive period can not only expand language acquisition theories, but more importantly, help identify early markers of DLD which will further aid in the development of targeted intervention.

PI_NAMEs: ZHAO, TIAN  (contact)

PROGRAM_OFFICER_NAME: COOPER, JUDITH

PROJECT_TERMS: 6 year old;Adult;Age Months;Auditory Brainstem Responses;Auditory system;Behavioral;Biomedical Research;Brain;clinically relevant;Communication impairment;Complex;Development;Disease;early experience;Early identification;Early Intervention;Exhibits;experience;Family history of;Growth;high risk;high risk infant;high risk population;improved;indexing;Individual;Infant;Inferior;interest;Intervention;Language;Language Development;Language Development Disorders;Language Disorders;language outcome;Learning;learning outcome;Link;Literature;Magnetoencephalography;Measures;Methods;Mission;National Institute on Deafness and Other Communication Disorders;neural;neuroimaging;neuromechanism;non-Native;Phonetics;Process;Research;response;Risk;Sensory;skills;sound;Source;Speech;Speech Discrimination;Speech Disorders;speech processing;Testing;theories;Time;virtual;Work

PROJECT_TITLE: Neural mechanisms underlying the sensitive period for phonetic learning in infants at-risk for Developmental Language Disorder

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Precision Medicine;Prevention;Rare Diseases;Social Determinants of Health;Tuberculosis

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE A public health approach to the management of children and adolescents living with HIV in sub-Saharan Africa has increased access to care but there remains a need for differentiated service delivery with intensified treatment and supportive strategies for children at higher risk of adverse outcomes. The clinical predication tools developed in this study will identify children at risk a-priori and avert unnecessary morbidity and mortality. This proposal will also define risk factors for TB disease in children living with HIV, identify those most likely to benefit from TB preventive therapy, and estimate the risk reduction associated with three different preventive therapy approaches; this knowledge will guide the design of prospective studies to investigate shorter tuberculosis preventive therapy regimens and inform evidence based TB preventive therapy strategies.

PI_NAMEs: KAY, ALEXANDER WILLIAM (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: 5 year old;Acquired Immunodeficiency Syndrome;Adherence;Adolescent;Adult;adverse outcome;Africa South of the Sahara;Age;age group;age related;AIDS related cancer;Alcohol consumption;antiretroviral therapy;Area;Award;Biometry;Botswana;career;Caring;Cessation of life;Child;Child Care;Child Health;Childhood;Clinic;Clinical;Clinical Data;clinical implementation;Clinical Informatics;clinical predictors;Clinical Research;cohort;Communicable Diseases;comorbidity;Country;Data;data management;Data Science;Data Set;Death Rate;Derivation procedure;design;Development;Disease;Drug usage;Enrollment;Epidemic;Epidemiology;evidence base;experience;follow-up;Foundations;Future;Goals;Guidelines;health literacy;Health Services Accessibility;Health system;Healthcare;high risk;HIV;HIV Seropositivity;HIV-infected adolescents;HIV/TB;Immunosuppression;improved outcome;Incidence;International;Internist;Intervention;isoniazid;Knowledge;Laboratories;Lesotho;low and middle-income countries;Malawi;Master of Science;Measures;Mental Depression;Mentored Research Scientist Development Award;Mentors;Mentorship;Modeling;Morbidity - disease rate;mortality;mortality risk;Opportunistic Infections;Outcome;Patient Care;Patient-Focused Outcomes;Patients;pediatric human immunodeficiency virus;pediatrician;Physicians;Policies;Population;Positioning Attribute;predictive tools;Preventive therapy;prospective;Prospective Studies;psychosocial;Psychosocial Factor;Public Health;public health research;Qualitative Methods;Regimen;Research;Research Personnel;research study;Resource-limited setting;Resources;Risk;Risk Estimate;Risk Factors;risk prediction;Risk Reduction;risk stratification;Scientist;screening;service delivery;skills;social stigma;Statistical Data Interpretation;Subgroup;Supervision;Surveys;Tanzania;Technical Expertise;Testing;therapy adherence;tool;Tuberculosis;Uganda;Validation;Viral;Work;World Health Organization

PROJECT_TITLE: Developing Clinical Prediction Tools to Define Strategies for Differentiated Service Delivery in Children and Adolescents Living with HIV in sub-Saharan Africa.

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSCIENCES

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE As age-specific incidence rates of Alzheimer’s disease and related dementias (ADRD) decline in the US, due, in part, to improvements in cardiovascular health, it is imperative that we study how favorable cardiovascular health promotes successful brain aging. We will apply advances in the field of neuroimaging to study brain network integrity by constructing maps of neural connections from multi-modal neuroimaging data on non- Latino White, Black, and Latino adults to determine how favorable cardiovascular health preserves brain network integrity, supports cognitive and motor functioning, and relates to ADRD neuropathologic burden. Given brain health is an important component of successful aging (as is reduced cardiovascular disease risk), this project has the potential to improve outcomes in less healthy older adults.

PI_NAMEs: LAMAR, MELISSA  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Address;Adult;advanced disease;Affect;age related;Aging;aging brain;Alzheimer's disease related dementia;American Heart Association;Anisotropy;Arterioloscleroses;Atrophic;Autopsy;Behavior assessment;behavioral outcome;Biological;Black race;Brain;brain health;Brain region;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;cerebrovascular pathology;Clinical;Cognitive;cohort;Cohort Studies;Complex;connectome;Data;Data Collection;Disease;Ensure;Ethnic Origin;Gait speed;Goals;Graph;gray matter;Health;Health Promotion;Hemorrhage;improved;improved outcome;Incidence;Infarction;late life;Latino;Life;Life Style;lifestyle intervention;Link;Literature;Magnetic Resonance Imaging;Magnetism;Maps;Memory;Methods;Minority Groups;Motor;multimodal neuroimaging;multimodality;neural;neural circuit;neuroimaging;neuropathology;older adult;Outcome;Participant;Pathologic;Population Heterogeneity;Positioning Attribute;Predisposition;preservation;Publishing;Race;Relaxation;Role;Semantic memory;Speed;Structure;success;Testing;Time;white matter;white matter damage;White Matter Hyperintensity;β-amyloid burden

PROJECT_TITLE: Favorable cardiovascular health, connectome integrity, and ADRD clinical outcomes and pathologic underpinnings in a diverse cohort.

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative Our memories constitute a crucial aspect of our identities and are essential to our ability to function effectively in the world. Motor memories – the library of skills we accumulate over a lifetime of experience and practice – are especially key for our ability to perform the activities of daily life. Despite their importance, relatively little is known about how motor memories are created, then consolidated, in the cerebral cortex, and hence we seek to understand those processes, toward the eventual goal of helping to improve therapeutic approaches for stroke recovery and improvements to brain-computer interface systems.

PI_NAMEs: BATISTA, AARON PAUL (contact);CHASE, STEVEN M;YU, BYRON M.

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Adopted;Animals;Appearance;arm movement;Basic Science;Behavior;Behavioral;Binding;Brain;brain computer interface;Cerebral cortex;Clinical;clinically relevant;Collaborations;Competence;Complement;Computers;Couples;Devices;dexterity;experience;experimental study;flexibility;Geometry;Goals;improved;Individual;insight;interest;learned behavior;Learning;Libraries;Life;Link;Macaca mulatta;Memory;memory consolidation;Memory Loss;Motor;motor control;Motor Cortex;motor learning;Motor Skills;Movement;neural;neural patterning;neuromechanism;Neurons;novel;Paralysed;Pattern;Performance;Population;Process;Productivity;Rehabilitation therapy;Research;Research Project Grants;restoration;Role;Savings;Sensory;Shapes;skills;Specific qualifier value;Stroke;stroke recovery;System;theories;Therapeutic;Time;tool;Work;Writing

PROJECT_TITLE: Memory Formation in Motor Cortex

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Climate-Related Exposures and Conditions;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This proposal will identify windows of fetal susceptibility to particulate air pollution exposure and characterize how air pollution impacts placenta signaling and regulatory mechanisms during mid-pregnancy and at term. Findings will advance our understanding of molecular pathways linking air pollution exposure with adverse pregnancy outcomes, including poor fetal growth, low birthweight and preterm delivery. This significant research advance has the potential to improve pregnancy outcomes by informing interventions focused on reducing exposure during vulnerable developmental windows and identifying early and relatively non-invasive placental biomarkers of air pollution exposure and pregnancy health.

PI_NAMEs: COWELL, WHITNEY  (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: adverse pregnancy outcome;Air Pollution;ambient air pollution;Big Data Methods;biobank;bioinformatics tool;Biological;Biological Markers;Birth Weight;Blood;Boston;Cell membrane;Child;Child Health;Chronic;Chronic Disease;cohort;Communication;Computing Methodologies;Data;Decidua Basalis;Development;Diameter;disease phenotype;Distant;early detection biomarkers;Early identification;early life exposure;early pregnancy;Encapsulated;Enrollment;Environmental Exposure;Environmental Health;epidemiology study;Epigenetic Process;Exposure to;extracellular;extracellular vesicles;fetal;Fetal Development;Fetal Growth;Fetal health;fetal programming;Fetus;fine particles;Future;Gene Expression;Gestational Age;Goals;high risk;improved;Individual;infancy;insight;intergenerational;Intervention;late life;Learning;Life Cycle Stages;Link;Low Birth Weight Infant;Low income;Maternal Exposure;Maternal Physiology;Maternal-Fetal Exchange;Measures;Mediating;Mediation;Mentors;Messenger RNA;meter;Methods;MicroRNAs;Minority;Minority Women;Modeling;Modification;Molecular;Molecular Epidemiology;Morbidity - disease rate;mortality;Mothers;Neonatology;New York City;Newborn Infant;novel;Outcome;Particulate;Pathway Analysis;Pathway interactions;Pattern;Phase;Placenta;Placental Biology;Play;pollutant;Population;Positioning Attribute;posttranscriptional;Predisposition;Pregnancy;pregnancy health;Pregnancy Outcome;Premature Birth;prenatal;prenatal exposure;Prevention strategy;programs;Public Health;Regulation;Research;Research Personnel;Resolution;Risk;Risk Factors;Role;sex;sexual dimorphism;Signal Transduction;Site;skills;spatiotemporal;Statistical Methods;Stress;System;Time;Tissues;Training;transcriptome sequencing;transcriptomics;treatment strategy;Untranslated RNA;Vesicle;Work

PROJECT_TITLE: Particulate air pollution, pregnancy outcomes, and the role of placental extracellular microRNAs


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: BOSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: Project Narrative / Relevance:  Cancer is a complex disease in which multiple genetic, genomic, epigenetic, environmental, and other factors combine to influence one’s risk—and ultimately to mediate disease development and progression. While cancer researchers recognize this complexity, most analytical methods in use have been built around relatively simple approximations that fail to capture the multifactorial nature of cancer. I propose to develop advanced computational methods to explore the regulatory networks that govern cancer development and response to therapies, including differences in men and women.

PI_NAMEs: QUACKENBUSH, JOHN  (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: analytical method;Biological;Biological Process;Cancer Biology;Characteristics;Complex;Computing Methodologies;Data;design;Development;Disease;Disease Management;disorder risk;Epigenetic Process;Genetic;Genetic Transcription;Genomics;Goals;Heart;insight;Malignant Neoplasms;Mathematics;Mediating;Medicine;men;Methodology;Methods;Modeling;multiple omics;Nature;network models;Phenotype;Property;Research Personnel;Risk;Structure;success;Systems Biology;treatment response;Woman;Work

PROJECT_TITLE: Unraveling the Complexities of Risk and Mechanism in Cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Evidence indicates that individuals with Alzheimer's disease and related dementias (ADRD) often receive suboptimal care at the end of life; however, its underlying causes and the strategies to effectively improve the quality of care at the end of life for ADRD have not been investigated well. Using an innovative database that includes comprehensive information on patient, physician, and health system factors, the investigators will identify key physician and health system factors (with a special focus on mutable factors, e.g., physician training in geriatrics and/or palliative care, and financial incentives targeted at health systems) associated with the quality of care for persons with ADRD at the end of life. This research has the potential to offer novel approaches for unraveling physician- and health system-level determinants of the quality of palliative and end-of-life care for persons with ADRD, and to provide a strong evidence base for developing actionable interventions that can effectively improve the quality of care for persons with ADRD at the end of life.

PI_NAMEs: TSUGAWA, YUSUKE  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Academic Medical Centers;accountable care organization;Address;Admission activity;Advance Care Planning;Affect;Age;aggressive therapy;Alzheimer's Disease;Alzheimer's disease related dementia;Big Data;Caregiver support;Caring;Cessation of life;Characteristics;Clinical;Clinical Research;cognitive ability;Data;Data Set;Database Management Systems;Databases;Dementia;dementia care;design;end of life;end of life care;evidence base;experience;Family;Fellowship;financial incentive;Funding;Geriatrics;Health Services Research;Health system;hospice environment;Hospitals;improved;Incentives;Individual;innovation;Intensive Care Units;Interdisciplinary Study;Intervention;Knowledge;Life;Link;Malignant Neoplasms;Measures;Mechanical ventilation;medical specialties;Medicare;Medicare claim;Methods;novel strategies;palliative;Palliative Care;Patient-Focused Outcomes;Patients;Performance;Persons;Physicians;Play;Policies;Policy Maker;Population;Positioning Attribute;Process;programs;provider factors;Quality of Care;Quality of life;Research;Research Personnel;Residencies;Role;Sampling;sex;Socioeconomic Status;Structure;Symptoms;systems research;Terminally Ill;Testing;therapy design;Training;Training and Education;Translational Research;United States National Institutes of Health;Variant

PROJECT_TITLE: The Impact of physician and health system factors on the quality of care for persons with Alzheimer's disease and related dementias at the end of life

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE

PHR: Public Health Relevance The ability to use coarse information about depth is critical to the safe execution of everyday tasks that require eye-hand coordination and navigating through the environment. This is particularly relevant to individuals with amblyopia whose depth perception is compromised because of an impaired ability to combine information from the two eyes. This proposal examines the basis for impaired depth and vision in the central visual field and examines the ability of the peripheral visual field to mediate depth information in amblyopia. These studies have implications for clinical tests that assess depth perception as well as training techniques to improve depth perception in amblyopia.

PI_NAMEs: VERGHESE, PREETI  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Affect;Amblyopia;Anisometropia;Area;Behavioral;Blindness;central visual field;Classification;Clinic;Clinical;Contrast Sensitivity;Cues;Data;density;Depth Perception;Development;Disparity;Electroencephalography;Electrophysiology (science);Environment;experience;extrastriate;Eye;eye hand coordination;Eye Movements;fovea centralis;Frequencies;Heterogeneity;Image;Impairment;improved;Individual;Lazy Eyes;Life;Location;Maps;Measurable;Measures;Mediating;Methods;Monitor;Monkeys;monocular;Movement;neural;neurodevelopment;novel;Participant;Perimetry;Peripheral;Physiological;Population;Procedures;Protocols documentation;Psychophysics;public health relevance;receptive field;recruit;Refractive Errors;Residual state;Resolution;response;Retina;sample fixation;Sampling;Signal Transduction;Source;source localization;Stimulus;Strabismus;Testing;Training;Training Technics;V1 neuron;Vision;Visual;Visual Acuity;Visual Cortex Disorder;Visual evoked cortical potential;Visual Fields

PROJECT_TITLE: Stereopsis and Suppression in Strabismus and Amblyopia


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Neurosciences;Osteoarthritis;Pain Research;Physical Activity

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE This study will combine brain imaging and neuromodulation tools to investigate the underlying neurobiological mechanisms of Baduanjin, a unique mind-body exercise. The findings will enhance our understanding of the mechanisms underlying mind-body exercise and facilitate the development of new pain management approaches.

PI_NAMEs: KONG, JIAN  (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: age-related disease;Amygdaloid structure;Anterior;Area;arterial spin labeling;attentional control;Baduanjin;Behavior;Bilateral;Brain;Brain imaging;Brain region;Cerebrovascular Circulation;Characteristics;chronic musculoskeletal pain;chronic pain management;cingulate cortex;Clinical;clinical application;Clinical Practice Guideline;Cognitive;Corpus striatum structure;Degenerative polyarthritis;design;Development;disability;Disabling;Disease;Dose;Exercise;follow-up;gray matter;Hippocampus;Home;Hour;Image;improved;Individual;Inferior;innovation;Insula of Reil;Intervention;intervention effect;Knee Osteoarthritis;knee pain;Learning;limb movement;Machine Learning;Measurement;Measures;Medial;Meditation;Mind-Body Intervention;mind/body;mindfulness;Motor;motor control;Motor Cortex;motor learning;Motor Skills;Movement;multidisciplinary;Muscle;Musculoskeletal Pain;neural;neurobiological mechanism;neuroregulation;Nonpharmacologic Therapy;older adult;Outcome;Pain;Pain management;pain reduction;Parietal Lobe;Patients;Performance;Pharmacologic Substance;Pilot Projects;Play;Prediction of Response to Therapy;Prefrontal Cortex;Property;Randomized;Recommendation;Research;response;Rest;Rewards;Role;Spinal Cord;Stretching;System;Techniques;Tendon structure;Testing;Thalamic structure;Therapeutic;Time;tool;transcranial direct current stimulation;Transcranial magnetic stimulation;treatment effect;treatment response;vector

PROJECT_TITLE: Enhancing modulation Effect of Baduanjin through Non-invasive Neuromodulation for knee Osteoarthritis

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

PHR: Axon degeneration is a hallmark of many neurodegenerative diseases. We discovered that metabolism regulated by the Liver kinase B1 (LKB1) pathway in oligodendrocytes plays a central role for the trophic support of axons. Here we will study the molecular mechanisms as to how glial LKB1 promotes axon stability.

PI_NAMEs: BEIROWSKI, BOGDAN  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: 5'-AMP-activated protein kinase;Adult;Alzheimer's Disease;Attenuated;Axon;axon injury;axonal degeneration;Biological;Central Nervous System;Cessation of life;Data;Defect;deprivation;Deterioration;Diameter;Disease;Electrophysiology (science);Energy Metabolism;Etiology;Failure;Fiber;Genetic;GLC2 protein;Glean;Glucose;Health Promotion;Homeostasis;imaging modality;Impairment;in vivo;Individual;interdisciplinary approach;Intoxication;Life Expectancy;lipid metabolism;liver ablation;Metabolic;Metabolic Pathway;Metabolism;metabolome;Microfluidic Microchips;Mitochondria;mitochondrial metabolism;Modeling;Molecular;mouse model;Multiple Sclerosis;mutant;Mutant Strains Mice;myelination;Nerve Degeneration;neural circuit;Neurodegenerative Disorders;Neuroglia;Neurologic;Neurological disability;new therapeutic target;novel;Oligodendroglia;Optic Nerve;Output;Pathway interactions;Phenotype;Phosphorylation;Phosphotransferases;Play;preservation;Regulation;Role;Schwann Cells;Secondary to;sensor;Signal Pathway;Signal Transduction;STK11 gene;Structure;Therapeutic;therapeutic target;tool;upstream kinase;white matter;Work

PROJECT_TITLE: Elucidating the Trophic Support of Long Axons by Metabolic Signaling in Oligodendrocytes

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Alzheimer’s disease is the leading cause of dementia in the United States. Variants in the apolipoprotein E (APOE) gene is strongly associated with the risk of Alzheimer’s disease. In order to understand the molecular mechanisms of Alzheimer's disease and identify targets for therapy, this study will investigate how specific missense variants affect apolipoprotein E and protein interactions using mass spectrometry-based proteomics.

PI_NAMEs: WIJERATNE, HR SAGARA  (contact)

PROJECT_TERMS: abeta accumulation;Abeta clearance;Affect;Affinity Chromatography;Age;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Amino Acid Sequence;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Apolipoproteins;Astrocytes;autosome;Binding;Biochemical;Biological;Biology;biophysical properties;Biophysics;Brain;cell type;Cholesterol;Cholesterol Homeostasis;Clinical;Data;Dementia;Dependovirus;Development;Diagnostic;disorder risk;DNA Resequencing;Doctor of Philosophy;Environment;executive function;extracellular;Genes;genetic risk factor;genetic variant;Genotype;high risk;Human;Individual;innovation;insight;Language;lipid transport;Lipids;Lipoproteins;Mass Spectrum Analysis;melting;Memory;Mentors;Metabolism;mild cognitive impairment;Modeling;Molecular;Mus;mutant;Mutation;Neurodegenerative Disorders;neurofibrillary tangle formation;neurotoxicity;Pathogenesis;Pathway interactions;Patients;Peptides;Phenotype;Physicians;Physiological;Physiology;Plasmids;Post-Translational Protein Processing;prognostic;Property;protein complex;protein folding;Protein Isoforms;protein protein interaction;Proteins;Proteome;Proteomics;rare variant;receptor;receptor binding;Regulation;Reporting;Research;Resources;Risk;Role;Scientist;Serotyping;Synaptic plasticity;System;targeted treatment;Techniques;Temperature;Therapeutic;transcriptome;transcriptome sequencing;transcriptomics;United States;uptake;Variant;Work;Yeasts

PROJECT_TITLE: Proteomic and functional analysis of missense variants of APOE associated with Alzheimer disease risk


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE There are wide disparities in home reading routines, kindergarten reading readiness and subsequent abilities, and numerous health outcomes, linked to inequitable access to reliable information and resources. Reading Bees is a new, free mobile application for parents that addresses these by providing clear, evidence-based literacy-related guidance and resources and awards for home reading behaviors, designed to efficiently complement existing pediatric, library and community programs. This 3-year project involves integration of new and enhanced app content (local resources, a Spanish version, LitCoin awards) and then conducting usability testing in three culturally distinct areas (Cincinnati OH, Miami FL, Huntington WV) with families from disadvantaged backgrounds, first in focus groups and then during clinic visits with use measured over 2 months, which will guide refinement and scaling into other areas.

PI_NAMEs: HUTTON, JOHN S. (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: 6 year old;Academy;Access to Information;Address;Adherence;Adult;Age;American;Android;Appalachian Region;Area;Attitude;Award;Bees;Behavior;Black race;Books;Brain;Caring;Categories;Child;Child Rearing;Childhood;Clinic Visits;Code;Cognitive;cognitive benefits;Collaborations;Communities;Complement;Complex;cost;cost estimate;COVID-19;COVID-19 pandemic;Data;design;Development;Disadvantaged;disadvantaged background;Disparity;early childhood;Emotional;empowerment;Environment;Evaluation;evidence base;experience;Face;fall risk;Family;financial incentive;flexibility;Focus Groups;Frequencies;Geography;Gifts;Goals;Growth;Health;health literacy;Health Personnel;Hispanic;Home;Household;Huntington Disease;Immigrant;impression;Improve Access;improved;Incentives;Inequity;infancy;Infrastructure;innovation;Journals;kindergarten;Knowledge;Language;Learning;Libraries;Link;literacy;Literacy Programs;marginalization;Measures;Minority;mobile application;Modeling;Nursery Schools;Outcome;Outcome Measure;Outcome Study;Parents;Pediatrics;pilot trial;Populations at Risk;Positive Reinforcements;Poverty;Process;programs;Provider;Race;Readiness;Reading;Recommendation;Reporting;Resources;Rural;School Enrollments;Schools;Series;Services;Shapes;skills;socioeconomic disadvantage;Spanish;Stress;stressor;Surveys;teacher;Testing;Time;tool;Translating;Trust;tutoring;United States National Library of Medicine;usability;verbal;Vocation;wellness visit;Work;Writing

PROJECT_TITLE: Reading Bees: Adapting and Testing a Mobile App Designed to Empower Families to Read more Interactively with Children in Distinct Geographical and Cultural Contexts

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Kidney Disease

PHR: PROJECT NARRATIVE  The Chronic Kidney Disease Prognosis Consortium (CKD-PC) was formed in 2009 to focus on improving the lives of patients with CKD. The CKD-PC now includes data on >30 million participants from >100 cohorts spanning >40 countries, and has provided evidence for a global definition of CKD, the acceptance of new surrogate endpoints in clinical trials, and the establishment of important risk tools for use in clinical care. In this renewal, the CKD-PC will build upon previous successes and continue to respond rapidly to changes in health care guidelines, delivery, and regulation to answer high priority questions facing the global CKD population.

PI_NAMEs: CORESH, JOSEF  (contact);GRAMS, MORGAN ERIKA

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Adult;Advisory Committees;Affect;Agonist;Albuminuria;antagonist;APOL1 gene;Arrhythmia;burden of illness;Calibration;Cardiovascular system;Caring;Cause of Death;Chronic Kidney Failure;Clinical;clinical care;Clinical Trials;cohort;Collaborations;Country;Data;Dementia;design;Detection;Diabetes Mellitus;Diagnosis;disease diagnosis;disease prognosis;Disease Progression;Educational workshop;effective therapy;epidemiology study;Equation;Evaluation;flexibility;frailty;Funding;Glomerular Filtration Rate;GLP-I receptor;Glucose;Grant;Guidelines;Health;health disparity;Healthcare;Heart;Heart failure;Hospitalization;Hypertension;improved;Incidence;Individual;Infection;inhibitor;innovation;Internships;Kidney;Kidney Diseases;Liquid substance;Malignant Neoplasms;Maps;Measures;Mentors;Meta-Analysis;Methods;Mineralocorticoid Receptor;Modeling;novel;Outcome;Participant;Patient Care;patient subsets;Patients;Performance;Phase;Play;Policies;Population;post gamma-globulins;Prevalence;prevent;Prevention;Productivity;prognostication;Public Health;Race;Recommendation;recruit;Regulation;Research;Research Personnel;Risk;risk variant;Role;screening;Sodium;Span 40;Special Population;Staging;Structure;success;Surrogate Endpoint;symporter;Testing;Therapeutic;tool;United States Food and Drug Administration;Work

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome;Prevention

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Narrative Our elucidation of the mechanisms of homology-directed chromosome damage repair will greatly enhance understanding of the etiology of breast, ovarian, and other cancers. The knowledge garnered from our endeavors will constitute the basis for developing novel cancer diagnostics and therapeutics, and will empower medical practitioners to predict drug response, counsel patients, and explain acquired drug resistance. !

PI_NAMEs: SUNG, PATRICK  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: acquired drug resistance;anti-cancer research;BARD1 gene;Biology;Biophysics;BRCA1 gene;BRCA2 gene;Breast;Cancer Center;Cancer Diagnostics;cancer prevention;Chemicals;Chromosomes;Counseling;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA replication fork;drug discovery;drug response prediction;empowerment;Etiology;Eukaryota;Foundations;Genetic study;Genome;genome integrity;Health Sciences;holistic approach;inhibitor;innovation;insight;Knowledge;Malignant Neoplasms;Mammals;Mediating;Medical;Modeling;Mutation;novel;Ovarian;PALB2 gene;Patients;Play;Positioning Attribute;preclinical study;preservation;repaired;Research;Research Institute;Role;single molecule;Stress;structural biology;Texas;Therapeutic;tool;Tumor Suppression;Tumor Suppressor Proteins;Universities

PROJECT_TITLE: Mechanisms of DNA Homology-directed Genome Repair and Tumor Suppression


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: TISCH CANCER INSTITUTE AT THE ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Principal Investigator/Director: Ramon Parsons, MD, PhD Public Health Relevance Statement: The Tisch Cancer Institute provides an infrastructure to advance basic, clinical and population health cancer research, so as to prevent cancer in healthy individuals and improve the lives of cancer patients and their families in our diverse communities. To accomplish this mission, the TCI has developed collaborative research programs that strive to translate discoveries to new therapies and to develop new prevention and delivery strategies with priority given to cancers affecting our catchment area. The Cancer Clinical Trials Office with its newly established Early Phase Trials Unit provides the infrastructure to conduct novel, investigator initiated protocols developed by TCI investigators.

PI_NAMEs: PARSONS, RAMON E (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Academic Medical Centers;Access to Information;Administrator;Affect;anti-cancer research;Award;biobank;Bioinformatics;biomedical data science;Biometry;Cancer Burden;Cancer Center Support Grant;cancer clinical trial;Cancer Control;Cancer Patient;cancer prevention;Cancer Research Project;cancer risk;cancer therapy;cancer type;Caring;Catchment Area;Clinical;clinical investigation;Clinical Investigator;Clinical Trials;Communities;design;Development;Disease;Doctor of Philosophy;early phase trial;Equipment;Equity;experience;Faculty;Family;first responder;Flow Cytometry;Focus Groups;Fostering;Foundations;Funding;Health Personnel;Human;Immunologic Monitoring;improved;improved outcome;Incidence;Individual;Informatics;Information Technology;Infrastructure;innovation;Leadership;Malignant Neoplasms;medical schools;meetings;Microscopy;Mission;Morbidity - disease rate;mortality;mouse genetics;Neighborhoods;New York City;next generation sequencing;novel;novel therapeutics;Pathology;Patients;Peer Review;Pilot Projects;population health;prevent;Prevention;Principal Investigator;programs;Protocols documentation;public health relevance;Research;Research Infrastructure;Research Personnel;Resource Sharing;Scientist;screening;Side;Site;Strategic Planning;Students;Training and Education;training opportunity;Translating;Translations;tumor immunology;United States National Institutes of Health;Work

PROJECT_TITLE: THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANT

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: MIAS, SHARON  (contact)

PROJECT_TERMS: anti-cancer research;Award;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Contracts;Decision Making;Dedications;Development;Faculty;Faculty Recruitment;Funding;Gifts;Goals;Grant;Health system;Human Resources;Information Technology;innovation;Institution;Lead;Malignant Neoplasms;medical schools;Occupational activity of managing finances;Process;programs;Resource Sharing;Resources;Vision;Work

PROJECT_TITLE: ADMINISTRATION


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

PI_NAMEs: GABRILOVE, JANICE L (contact)

PROJECT_TERMS: Accreditation;Address;American Society of Clinical Oncology;anti-cancer research;Area;Award;Cancer Biology;Cancer Burden;Cancer Center Support Grant;Cancer Control;cancer prevention;career;career development;Career Mobility;Caring;Clinical;Clinical and Translational Science Awards;clinical encounter;Clinical Investigator;Clinical Oncology;clinically relevant;Communities;Dedications;design;Disease;Disparity;doctoral student;Education;Ethnic Origin;Evaluation;experience;Faculty;Fellowship;Fostering;Funding;Future;Goals;graduate school;Grant;hackathon;Health;Health Professional;high school;Home;improved;Individual;innovation;interdisciplinary collaboration;Investments;Knowledge;Lead;Malignant - descriptor;Malignant neoplasm of liver;Malignant Neoplasms;medical schools;Medical Students;Medicine;Mentors;Methodology;Mission;multidisciplinary;National Center for Advancing Translational Sciences;next generation;novel;Outcome;Physicians;Population;post-doctoral training;Postbaccalaureate;pre-doctoral;programs;Race;Recommendation;Research;Research Personnel;Research Training;Resources;Scholars Program;Science;Scientist;skills;Social Work;student training;Students;Training;Training Programs;Translating;translational cancer research;translational immunology;Translational Research;translational scientist;undergraduate student;Underrepresented Minority

PROJECT_TITLE: Cancer Research Career Enhancement and Related Activities


PI_NAMEs: OCHANDO, JORDI  (contact)

PROJECT_TERMS: Antigens;Area;ATAC-seq;Basic Science;Biological;cancer cell;Cancer Center Support Grant;Cancer Patient;Cancer Research Project;Cell Separation;Cell surface;Cells;Cellular biology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;ChIP-seq;clinical investigation;Clinical Research;Collaborations;Complex;Consultations;cost effectiveness;Data Analyses;Dedications;Development;Diagnosis;Disease;Doctor of Philosophy;Education;Equipment;Flow Cytometry;Flow Cytometry Shared Resource;Fluorescence-Activated Cell Sorting;Health;Human;Human Resources;improved;innovation;Institution;instrumentation;Knowledge;Laboratories;Lead;lipidomics;Malignant Neoplasms;medical schools;member;metabolomics;Methods;Mission;Molecular;Mus;pathogen;Process;Productivity;programs;Proteomics;recruit;Research Personnel;Research Project Grants;Resource Sharing;Sampling;Services;Site;Specialist;Technology;Training;transcriptome sequencing;Translational Research

PROJECT_TITLE: Flow Cytometry


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: KELLEY, KEVIN A (contact)

PROJECT_TERMS: anti-cancer research;Cancer Center Support Grant;Cancer Model;Cells;Clone Cells;Core Facility;CRISPR/Cas technology;Cryopreservation;Dedications;Derivation procedure;DNA;Doctor of Philosophy;Education;Embryo;embryo cryopreservation;Embryology;embryonic stem cell;Gene Modified;Gene Targeting;Generations;Genes;genome editing;Germ Cells;in vivo;Individual;Injections;Institution;Knock-out;Laboratories;Lead;Maintenance;male;Malignant Neoplasms;medical schools;member;Methods;Modernization;Mouse Embryonic Stem Cells;mouse genetics;mouse model;Mus;mutant;mutant mouse model;novel;Price;Production;programs;Recording of previous events;Research Personnel;Resource Sharing;Resources;Rodent;Role;sperm cell;sperm cryopreservation;System;Techniques;Transgenic Mice;Transgenic Organisms;zygote

PROJECT_TITLE: Mouse Genetics


PI_NAMEs: BENSON, DEANNA L (contact)

PROJECT_TERMS: anti-cancer research;Biological;Calcium;Cancer Center Support Grant;cell behavior;Cell Communication;Cell Count;cell growth;Cell Lineage;Cells;Characteristics;Collaborations;Computer software;computerized data processing;Computers;Consultations;cost;Cultured Cells;Dedications;design;Development;Doctor of Philosophy;Education;Educational workshop;Electron Microscopy;Engineering;Equipment;experience;experimental study;Fluorescence;Fluorescence Resonance Energy Transfer;Funding;gigabyte;graduate school;Grant;Hour;Image;Image Analysis;imaging approach;Imaging Device;imaging study;Immune;Immunofluorescence Immunologic;improved;in vivo;in vivo imaging;instrument;instrumentation;International;intravital imaging;Invaded;Laboratories;Lead;Light;light microscopy;light transmission;live cell imaging;Malignant Neoplasms;Maps;medical schools;medical specialties;member;Methodology;Microscope;Microscopy;Mission;Modality;multi-photon;Neoplasm Metastasis;neoplastic cell;new technology;operation;Organ;Organoids;Paper;particle;Primary Neoplasm;Productivity;programs;protein expression;Proteins;Protocols documentation;Publications;Publishing;Quantitative Microscopy;Recording of previous events;Research;Research Personnel;Resolution;Resource Sharing;Resources;Role;Science;Scientist;Series;Services;Signal Transduction;Site;skills;Specialist;Speed;superresolution imaging;superresolution microscopy;System;Techniques;Time;Tissues;Training;training opportunity;Transmission Electron Microscopy;Tumor Cell Migration;tumor diagnostic;ultra high resolution;Vendor;Work

PROJECT_TITLE: Microscopy


PI_NAMEs: MAZUMDAR, MADHU MADHU (contact)

PROJECT_TERMS: Address;analytical method;anti-cancer research;Biometry;Biostatistics Shared Resource;Cancer Center Support Grant;cancer type;Clinical Investigator;Clinical Research;Consultations;Core Facility;Data;Databases;design;Development;Doctor of Philosophy;Education;Ensure;Environment;Faculty;innovation;laboratory experience;Language;Lead;Malignant Neoplasms;Manuscripts;medical schools;Methodology;multidisciplinary;Nature;novel;Play;Population Sciences;Preparation;programs;Research;Research Design;Research Personnel;research study;Science;Statistical Data Interpretation;Statistical Methods;statistical service;Structure

PROJECT_TITLE: Biostatistics


PI_NAMEs: GNJATIC, SACHA  (contact)

PROJECT_TERMS: analytical tool;Applications Grants;Area;Basic Science;Bioinformatics;Biological Assay;Blood;Body Fluids;Bone Marrow;Bone Tissue;Cancer Center Support Grant;Cancer Etiology;Cancer Patient;Cells;Clinical;Clinical Research;Collaborations;complex data;Core Facility;cost effectiveness;Data;Data Analyses;Data Management Resources;data quality;Data Set;Dedications;Development;Disease;DNA;Doctor of Philosophy;Ensure;enzyme linked immunospot assay;Flow Cytometry;Foundations;Funding;Goals;high dimensionality;high throughput technology;Human;Immune;Immunogenomics;Immunologic Factors;Immunologic Monitoring;Immunologist;Immunology;immunotherapy trials;Industry;innovation;insight;Institution;instrument;Laboratories;Language;Link;machine learning pipeline;Malignant Neoplasms;Maps;medical schools;member;Methods;microbiome;Mission;Molecular;novel marker;Pathway interactions;Patients;Phenotype;Preparation;Procedures;programs;Proteins;Proteomics;Protocols documentation;Publications;Reagent;Reproducibility;Research;Research Personnel;Resource Sharing;response;RNA;Sampling;Services;Technology;technology platform;Therapeutic;Tissue imaging;tissue mapping;Tissue Sample;Tissues;transcriptomics;translational study;United States National Institutes of Health

PROJECT_TITLE: Human Immune Monitoring Center


PI_NAMEs: POSNER, MARSHALL R (contact)

PROJECT_TERMS: Area;Award;Back;bench to bedside;cancer care;cancer cell;Cancer Center Support Grant;cancer clinical trial;Cancer Patient;cancer therapy;Clinic;clinical development;clinical investigation;clinical translation;Clinical Trials Design;Collaborations;Direct Costs;Discipline;Doctor of Philosophy;Education;Fostering;Funding;Goals;Immune system;Immunooncology;improved;innovation;Laboratories;Malignant Neoplasms;medical schools;meetings;member;Mission;novel therapeutic intervention;Paper;Patients;Peer Review;preclinical development;Process;programs;Publishing;Research;Science;Therapeutic;Therapeutic Trials;therapy development;Translating;treatment strategy;tumor microenvironment;Work;working group

PROJECT_TITLE: Cancer Clinical Investigation


PI_NAMEs: BHARDWAJ, NINA  (contact)

PROJECT_TERMS: Animal Model;anti-CTLA4;anti-PD-1;anti-PD-L1;Award;Biological Models;cancer care;cancer cell;Cancer Center Support Grant;Cancer Patient;cancer therapy;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chimeric antigen receptor T cells;clinical application;clinical investigation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Dendritic Cells;design;Development;Direct Costs;Doctor of Philosophy;Elements;Equilibrium;Functional disorder;Funding;Genomics;Goals;Human;human disease;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immune System Diseases;Immune Targeting;Immunologic Markers;Immunology;Immunotherapeutic agent;Immunotherapy;improved;in silico;innate immune function;Innate Immune System;innovation;Intrinsic factor;Leadership;Lesion;Macrophage;Malignant Neoplasms;Mediating;medical schools;member;Modeling;Molecular;Myeloid-derived suppressor cells;Natural Killer Cells;novel;Paper;Pathway interactions;Patients;Peer Review;Population;pre-clinical;Pre-Clinical Model;programs;Publishing;recruit;Refractory;Research Personnel;Resistance;response;response biomarker;Risk;Role;Sampling;single cell sequencing;Stromal Cells;T cell therapy;T-Lymphocyte;Technology;Testing;Translating;treatment response;tumor;tumor growth;tumor immunology;tumor microenvironment;tumor progression;Work

PROJECT_TITLE: Cancer Immunology


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dietary Supplements;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Nutrition;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Nearly one in five American adults who survived the coronavirus disease (COVID-19) are still suffering from post-acute COVID-19 syndrome (PACS), a complex systemic disease that manifests in fatigue and muscle weakness that substantially limits one or more major life activities. For older adults, having PACS coupled with an inadequate diet may compound their health deterioration and hasten their physical function decline. To ameliorate recovery, men and women aged 50 years or older with PACS will be randomized to a 16-week dietary intervention group (N=28) following the ‘Whole-Diet Approach’ based on the new Dietary Guidelines for Americans (DGA 2020-2025) with a focus on the intake of nutrients high in anti-inflammatory activities via foods and/or supplements (e.g., vitamin D, omega-3, whey protein) and will be compared to their counterparts who were randomized to the attention control group (N=28).

PI_NAMEs: BIGMAN, GALYA  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: 2019-nCoV;Abate;Academia;Adherence;Adult;aged;Aging;American;Anti-Inflammatory Agents;attentional control;Attenuated;Baltimore;bean;Biological Markers;Black Populations;career;Clinical Trials;common symptom;comparison control;Complex;Control Groups;coronavirus disease;Coupled;COVID-19;Deterioration;Diet;dietary;Dietary Fiber;dietary guidelines;Dietary Intervention;Dietitian;Disease;Dual-Energy X-Ray Absorptiometry;Education;eligible participant;Equilibrium;Equipment and supply inventories;ethnic minority;Exhibits;experience;Fatigue;Feasibility Studies;Food;Fruit;Future;Geriatrics;group intervention;Hand Strength;Health;Healthy Eating;Hispanic Populations;Hour;improved;indexing;Individual;Infection;Inflammation;Inflammatory;Intake;Interleukin-6;Intervention;Intervention Studies;Leadership;Life;Long COVID;Maryland;Measures;men;Mentored Research Scientist Development Award;Mentors;Mentorship;multidisciplinary;Muscle;muscle form;Muscle function;Muscle Weakness;Not Hispanic or Latino;Nutrient;nutrition;Nutritional;Nutritional Study;older adult;Omega-3 Fatty Acids;pandemic disease;Participant;Pathology;Physical Function;Physical Performance;Plants;preservation;prevent;Proteins;Public Health;racial minority;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;Research Personnel;Sampling;Seafood;skills;statistics;Structure;Symptoms;Systemic disease;Testing;Thinness;Training;Translating;Underrepresented Minority;Universities;Vegetables;Vitamin D;Walking;Whey Protein;Woman

PROJECT_TITLE: A Diet Intervention Study To Mitigate Fatigue Symptoms And To Improve Muscle And Physical Function In Older Adults With Post-Acute COVID-19 Syndrome

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Obesity;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: TAIOLI, EMANUELA  (contact)

PROJECT_TERMS: Address;Affect;Attention;Award;Behavioral;Cancer Biology;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;Carcinogens;Catchment Area;Characteristics;Chemicals;Direct Costs;Disparity;Doctor of Philosophy;early detection biomarkers;Early Diagnosis;early screening;Environmental Exposure;Evaluation of Risk Factors;Exposure to;Funding;Goals;health care delivery;health disparity;Hepatitis C virus;high risk;Human papilloma virus infection;improved;Incidence;Malignant Neoplasms;medical schools;member;mortality;Neighborhoods;novel strategies;Obesity;Oncology;Paper;Passive Smoking;patient oriented;Peer Review;Persons;Population;programs;Publishing;Quality of Care;Quality of life;Research;Research Design;Research Project Grants;response;Risk;Risk Factors;screening;Screening for cancer;smoking exposure;social;Symptoms;treatment effect;Underserved Population

PROJECT_TITLE: Cancer Prevention and Control


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: AGUIRRE-GHISO, JULIO A. (contact)

PROJECT_TERMS: Acceleration;Address;Area;Award;Basic Science;Biochemical;Biological Markers;Biological Models;Biology;cancer cell;Cancer Center Support Grant;Cancer Control;cancer initiation;cancer prevention;cancer recurrence;cancer type;Catchment Area;Cells;Chromatin;Clinical;clinical investigation;Clinical Pathways;clinical translation;Clinical Trials;Collaborations;Communities;Development;Diagnosis;Direct Costs;Disease;Drosophila genus;Epigenetic Process;Focus Groups;Fostering;Funding;Gene Expression Regulation;Genetic;Genetic Transcription;Goals;Grant;Growth;Hospitals;improved;Incidence;Indolent;industry partner;International;Knowledge;Lead;Liquid substance;Maintenance;Malignant neoplasm of liver;Malignant Neoplasms;meetings;member;Modeling;Modification;mortality;mouse model;NCI-Designated Cancer Center;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel marker;novel therapeutic intervention;Organoids;Output;Paper;Pathway interactions;Patient-Focused Outcomes;Peer Review;personalized medicine;Phase;Population;Positioning Attribute;premalignant;Primary Cancer Prevention;Primary Neoplasm;Principal Investigator;programs;Publications;Publishing;Recurrence;Research;Research Personnel;Residual Neoplasm;Resistance;Science;Signal Transduction;Solid Neoplasm;Strategic Planning;success;targeted treatment;therapeutic biomarker;Therapeutic Intervention;therapeutic target;Training and Education;training opportunity;Translating;translational impact;translational potential;tumor immunology;tumor initiation;tumor microenvironment;tumor progression;Universities;Vision;Work;working group

PROJECT_TITLE: Cancer Mechanisms


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Liver Disease;Lung;Lung Cancer;Pancreatic Cancer;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health;Urologic Diseases;Women's Health Research

PI_NAMEs: BICKELL, NINA A. (contact)

PROJECT_TERMS: Address;Affect;African;Alcohols;Biological;Black race;Breast Cancer Detection;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer risk;care coordination;Catchment Area;Cities;cohort;Collaborations;college;colon cancer patients;Colon Carcinoma;Colonoscopy;Colorectal;Colorectal Cancer;Communities;Community Actions;community engaged research;community engagement;Community Outreach;Development;Diagnosis;Disease;Disparity;disparity reduction;Diverse Workforce;Drops;Early Diagnosis;Evaluation;Excess Mortality;experience;Face;Future;Geography;Health;health care delivery;Hepatitis;Hepatitis C;Hispanic;Improve Access;improved;Incidence;Institution;Language;Lead;leukemia;Liver;Lung;lung cancer screening;male;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Mammography;medical schools;Melanoma;Methods;Minority;Minority Groups;Monitor;Morbidity - disease rate;mortality;Multiple Myeloma;Needle-Exchange Programs;Neighborhoods;New York City;outreach;patient navigation;Poverty;programs;Prostate;Public Housing;Recovery;Research;Research Institute;Risk Factors;screening;Services;Side;Site;Sterile coverings;Testing;Thyroid Gland;training opportunity;treatment disparity;underserved area;Uterine Cancer;Voice;Work;working class

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Data Science

PROJECT_TERMS: anti-cancer research;Award;Big Data;biobank;Bioinformatics;biomedical data science;Cancer Center Support Grant;Cancer Patient;Catchment Area;Clinical;Clinical Data;Clinical Sciences;Collaborations;Communities;Development;Disease;Doctor of Philosophy;Electronic Health Record;Epidemiology;Family;Funding;genomic data;Goals;Human;improved;Individual;Informatics;Infrastructure;Interdisciplinary Study;Laboratories;Lead;Leadership;Malignant Neoplasms;medical schools;member;Mission;neoplasm registry;next generation sequencing;Pathology;Pilot Projects;population health;Population Sciences;preference;prevent;Process;programs;Research;research facility;Research Personnel;Resource Sharing;Services;Solid Neoplasm;Strategic Planning;Translational Research;Tumor Tissue

PROJECT_TITLE: Developmental Funds


PROJECT_TERMS: Address;Administrator;anti-cancer research;Award;Basic Science;Cancer Center;Cancer Center Support Grant;Cancer Patient;Clinical Sciences;Clinical Services;Collaborations;community engagement;Doctor of Philosophy;Ensure;Equity;Evaluation;Goals;Growth;Information Technology;Investments;Lead;Leadership;Malignant Neoplasms;medical schools;meetings;operation;Participant;Policies;Population Sciences;Process;recruit;Research;Resources;Role;Series;Strategic Planning;Structure;System;Training and Education;training opportunity;Vision

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Aging;Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Women's Health Research

PI_NAMEs: GALSKY, MATTHEW  (contact)

PROJECT_TERMS: Accountability;Adult;African American;African American population;Age;age group;Award;Budgets;cancer care;Cancer Center Support Grant;cancer clinical trial;Cancer Patient;cancer therapy;Caring;Catchment Area;Child;Childhood;Clinical;Clinical Data;Clinical Nursing Research;Clinical Protocols;Clinical Research;clinical trial enrollment;Clinical Trials;Clinical Trials Data Monitoring Committees;Communication;Data;data management;Dedications;Development;Disease;Event;evidence base;Family;Geographic Locations;Geography;Guidelines;high risk;Hispanic;Hispanic Populations;human old age (65+);improved;Individual;innovation;Intervention;Lead;life span;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant Neoplasms;medical schools;member;Minority;Minority Groups;minority patient;Minority Women;Mission;Monitor;Monitoring Clinical Trials;multidisciplinary;Oncologist;Oncology;Participant;participant enrollment;patient population;Patients;Pediatric Hematology;Pediatric Oncology Group;Phase;Population;Protocols documentation;recruit;Reporting;repository;Research;Research Personnel;Safety;safety study;sound;Structure;Therapeutic;Therapeutic Clinical Trial;Therapeutic Intervention;Therapeutic Trials;timeline;Training;Training and Education;Woman;women's treatment

PROJECT_TITLE: Clinical Protocol and Data Management


PI_NAMEs: SMITH, CARDINALE B (contact)

PROJECT_TERMS: authority;Biometry;Cancer Center Support Grant;Categories;Clinical Research;Data;design;Disease;Educational workshop;Ensure;Focus Groups;Goals;Guidelines;Health system;Lead;Malignant Neoplasms;medical schools;Mission;Monitor;Protocols documentation;recruit;Research;Safety;System

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: NARRATIVE CD8+ cytolytic T cells constitute an important limb of the immune response against tumors. Often, though, CD8+ T cells and their engineered derivatives such as CAR T cells become ‘exhausted’ in the tumor environment, devolving into a state with reduced ability to kill tumor cells. In this project, we will continue our longstanding collaboration to investigate intracellular mechanisms that determine whether a CD8+ T cell will or will not mount an effective immune response.

PI_NAMEs: HOGAN, PATRICK  (contact);RAO, ANJANA

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Accounting;Acute;Address;Affect;antigen-specific T cells;Antigens;Area;Binding;Calcineurin;Calcium;Calcium Channel;Cancer Control;cancer infiltrating T cells;cancer therapy;CAR T cell therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Surface Receptors;Cell Survival;Cells;chimeric antigen receptor T cells;Chronic;Clinic;Clinical;Clinical Oncology;Collaborations;CTLA4 gene;cytokine;Cytotoxic T-Lymphocytes;Development;effective therapy;effector T cell;Engineering;Environment;exhaust;exhaustion;experience;Exposure to;Family;follow-up;Fostering;Funding;Gene Expression;gene induction;Genes;Genetic Transcription;Hematologic Neoplasms;Human;Immune;immune checkpoint blockade;Immune response;Immunotherapy;Impairment;improved;Individual;Knowledge;Limb structure;Link;Lymphocyte;member;Memory;Messenger RNA;Modernization;Molecular;mouse model;Mus;neoplastic cell;NR4A1 gene;nuclear factors of activated T-cells;Nuclear Receptors;Paper;Pathway interactions;patient subsets;Patients;PD-1/PD-L1;PDL1 pathway;pharmacologic;Physiological;Play;prevent;Process;Production;programmed cell death protein 1;programs;Protein Family;Proteins;receptor;Recurrence;Recurrent tumor;Research;Research Project Grants;response;Risk;Role;Signal Pathway;Signal Transduction;Solid Neoplasm;success;T cell response;T-Cell Receptor;T-Lymphocyte;therapy design;Time;Titrations;transcription factor;Transcription Factor AP-1;tumor;Tumor Antigens;Tumor Expansion;Tumor-Infiltrating Lymphocytes;Up-Regulation;Viral Cancer;Virus Diseases;Work

PROJECT_TITLE: Signal transduction and gene induction in lymphocytes

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: PROJECT NARRATIVE Fetal Alcohol Spectrum Disorders are characterized by cognitive abnormalities in offspring exposed to alcohol during pregnancy. One of the most common cognitive deficits in Fetal Alcohol Spectrum Disorders involve impaired learning and memory and altered hippocampal function. A complete understanding of the neural bases of learning and memory deficits in Fetal Alcohol Spectrum Disorders is needed to ultimately identify treatments that may mitigate impacts later in life.

PI_NAMEs: SANCHEZ, LILLIANA MAY (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: alcohol consumption during pregnancy;alcohol exposure;alcohol research;Animal Model;Animals;base;Behavior;Behavioral;Biological Markers;Blood alcohol level measurement;Cells;Characteristics;Child;Cognitive;Cognitive deficits;Coupling;density;Development;Doctor of Philosophy;Electrophysiology (science);Environment;experience;Face;Fellowship;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Frequencies;Future;Hippocampus;Human;Immobilization;Impaired cognition;Impairment;Individual;Intervention;Laboratories;Learning;Life;Location;Memory;Memory impairment;Modeling;Morphology;neural;Neurobehavioral Manifestations;neurobiological mechanism;Neurobiology;Neurons;offspring;Paired-Associate Learning;Performance;Periodicity;Phase;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Rattus;reading comprehension;recruit;Research Personnel;Role;School-Age Population;System;Task Performances;Testing;Thinking;Work

PROJECT_TITLE: Rhythms of Hippocampal Function and Memory Deficits After Moderate Prenatal Alcohol Exposure


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Infectious Diseases;Pediatric;Precision Medicine;Sepsis

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Leveraging multi-omics to maximize the scientific value of pediatric sepsis biorepository and advance patient endotyping. PROJECT NARRATIVE:  Children with sepsis—a life threatening condition due to an abnormal patient response to an infection— represent a mixed group with varying underlying biology. Our incomplete knowledge of disease mechanisms within subgroups of septic patients has prevented the development of the right drugs for the right patients. To address this problem, we seek to use our vast collection of blood samples from children with sepsis to find out whether an understanding of how genes are turned on and off can be used to improve sepsis outcomes.

PI_NAMEs: ATREYA, MIHIR R (contact);KAMALESWARAN, RISHIKESAN ;SANCHEZ-PINTO, LAZARO NELSON

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Affect;Antibiotics;bead chip;biobank;Bioinformatics;Biological;biological heterogeneity;Biology;Blood specimen;Characteristics;Child;Childhood;Clinical;Clinical Data;Clinical Trials;clinically relevant;clinically significant;cohort;Collection;Communities;CpG Islands;Critical Illness;Critically ill children;Data;data integration;Data Set;Databases;Derivation procedure;Development;Dimensions;Disease;disorder subtype;DNA;DNA Methylation;DNA methylation profiling;efficacious treatment;Electronic Health Record;Ensure;Epigenetic Process;epigenome;epigenomics;Equity;Evolution;Factor Analysis;Feasibility Studies;Foundations;Functional disorder;Funding;Future;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene regulatory network;Genes;Genetic Transcription;Health;Human;Immune response;improved;Infection;Knowledge;Laboratories;Life;Link;Malignant Neoplasms;Messenger RNA;Methodology;Methods;Methylation;methylome;methylomics;Modeling;Molecular;Morbidity - disease rate;mortality;multiple omics;National Institute of General Medical Sciences;Nature;novel;Organ;Outcome;Pathway interactions;Patient Care;patient response;patient subsets;Patient-Focused Outcomes;Patients;Pattern;pediatric patients;pediatric sepsis;performance tests;Pharmaceutical Preparations;Phase;Phased Innovation Awards;power analysis;precision medicine;Precision therapeutics;prevent;Process;public health emergency;Quality Control;Reporting;repository;Research;Research Personnel;RNA;Role;Sampling;scale up;Scientific Advances and Accomplishments;Sepsis;septic patients;Septic Shock;Series;Specimen;Subgroup;systemic inflammatory response;targeted treatment;Testing;Therapeutic;Time;transcriptome;transcriptome sequencing;transcriptomics;treatment response;Validation;Whole Blood

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE HIV-1 contains multiple essential components including conserved targets that may be amenable to drug design. Our understanding of HIV structure and how it incorporates its envelope protein has been mostly limited to studies of components in isolation. Here, we will combine cutting edge structural, computational, biochemical, and virologic approaches to reveal how key components interact in a native context within HIV intact virus particles and develop new drugs to block these crucial interactions.

PI_NAMEs: DERDEYN, CYNTHIA ANN (contact);GNANAKARAN, SANDRASEGARAM ;LEE, KELLY KEISEN

PROGRAM_OFFICER_NAME: ZHOU, YAN

PROJECT_TERMS: Amino Acid Substitution;Anti-viral Agents;Binding;Biochemical;Biochemistry;Biological Assay;Cell Membrane Permeability;cell type;Cells;Charge;cost;Coupled;Cryo-electron tomography;Cyclic Peptides;Cytoplasmic matrix;Cytoplasmic Tail;Data;density;design;Drug Design;env Gene Products;Epitopes;Evaluation;fitness;flexibility;Generations;Goals;Grain;HIV;HIV envelope protein;HIV-1;Image;in silico;in situ imaging;In Vitro;inhibitor;innovation;insight;Length;Life;Lipids;Lytic;Mechanics;Membrane;Membrane Lipids;Modeling;Molecular;Molecular Cloning;molecular dynamics;multi-scale modeling;multidisciplinary;Mutation;Nature;novel;novel therapeutics;particle;Peptides;Phosphatidylinositol 4,5-Diphosphate;Positioning Attribute;Production;Protein Engineering;Recombinants;Reporting;Resolution;Role;simulation;Structure;synergism;Testing;Time;Transmembrane Domain;transmission process;Variant;Viral;Viral Physiology;Virion;virology;Virus;virus testing;Work

PROJECT_TITLE: Interplay of the HIV-1 Env cytoplasmic tail, Gag-MA, and membrane: resolving molecular detail and blocking assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-E(02)]