ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Behavioral and Social Science;Cardiovascular;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative Our long-term goal is to reduce type two diabetes (T2D)-related health disparities within Choctaw Nation of Oklahoma (CNO) communities and prevent future complications such as cardiovascular disease and hypertension. Toward that goal, we propose to analyze four years of electronic medical record data generated by a large, state-of-the-art tribal healthcare system to investigate the relationship between medication adherence and cardio-metabolic control indicators (C-MCI), to develop models that predict future C-MCI, and identify facilitators to and barriers of medication adherence. Our results will yield insight to improve medication adherence and C-MCI among American Indians, consistent with CNO’s State of the Nation’s Health Report 2017 goal of reducing T2D and its complications and to improve C-MCI among CNO patients and other American Indian communities based on future research with data from additional tribes.

PI_NAMEs: SCARTON, LISA  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Adherence;Adult;Adverse effects;Affect;Age;Algorithms;American Indian community;American Indian Population;American Indian Tribe;American Indians;Anti-Hypertensive Agents;Blood Pressure;Body mass index;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Caring;Choctaw Nation of Oklahoma;Chronic Kidney Failure;Cohort Studies;Communities;comorbidity;Complications of Diabetes Mellitus;Computerized Medical Record;copayment;cost;Data;Data Sources;demographics;depressive symptoms;diabetes distress;diabetes management;Disease Outcome;Distant;Dyslipidemias;Electronic Health Record;electronic health record system;Ethnic Population;experience;Female;forgetting;Future;Glucose;Glycosylated hemoglobin A;Goals;Health;health care settings;health disparity;Health Services;Healthcare;Healthcare Systems;Heart;High Prevalence;human old age (65+);Hyperinsulinism;Hypertension;impaired glucose tolerance;improved;informant;insight;Insulin Resistance;Intervention;Interview;Knowledge;Lipids;Location;Logistic Regressions;Longitudinal Studies;Low-Density Lipoproteins;Machine Learning;machine learning model;male;Measures;Medicare;medication compliance;Metformin;Modeling;mortality;mortality risk;Nature;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Obesity;older adult;Oral;Patients;Pharmaceutical Preparations;Pharmacy facility;population based;Poverty;predictive modeling;Prevalence;prevent;Prevention program;racial population;random forest;Recommendation;Reporting;Research;Reservations;residence;Risk;Risk Factors;Role;Rural Community;Service setting;sex;social health determinants;System;Techniques;Translations;tribal health;tribal healthcare;tribal lands;Tribes;United States Indian Health Service;virtual;young adult

PROJECT_TITLE: Medication Adherence and Cardio-Metabolic Control Indicators among Adult American Indians Receiving Tribal Health Services

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Our proposed research will provide novel evidence on the effect of massive air pollution exposure on cardiometabolic health and how this exposure interacts with subsequent environmental exposures. Our study may uncover new health conditions linked to World Trade Center-related exposures and therefore has vast implications on health care costs and accessibility of treatment for World Trade Center responders and survivors. Moreover, evidence of extreme air pollution exposure as a source of population vulnerability can inform targeted interventions that reduce the risk of air pollution-related health outcomes among populations exposed to extreme air pollution events such as wildfires or smog.

PI_NAMEs: YITSHAK SADE, MAAYAN  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Address;Air Pollution;Asbestos;cancer risk;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Caring;Certification;Chemicals;Cholesterol;Chronic;climate change;climate instability;clinical center;cohort;Complex Mixtures;Data;data centers;Diabetes Mellitus;Disasters;Disease;disorder risk;Dust;Emergency Medical Technicians;Environmental Exposure;Environmental Risk Factor;Equipment;Event;Exposure to;fine particles;Fogs;follow-up;food environment;Funding;Future;Glucose;Health;Health Care Costs;Health Food;Healthcare;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Home;Hour;Human;Incidence;innovation;insight;Intervention;Laboratories;LDL Cholesterol Lipoproteins;Learning;Length;Link;London;Low-Density Lipoproteins;Malignant Neoplasms;Measures;member;Metals;Methods;Modeling;Modernization;Monitor;Myocardial Infarction;Noise;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Particulate;Physical Examination;Police;Policies;pollutant;Pollution;poor health outcome;Population;Positioning Attribute;Predisposition;programs;Publishing;Questionnaires;Recovery;repository;Research;Resolution;Respirators;respiratory;Respiratory Disease;response;Retrospective cohort study;Risk Reduction;Role;Serum;Severities;Site;Smog;social vulnerability;Source;spatiotemporal;survival outcome;Survivors;Temperature;Terrorism;Testing;Time;Vulnerable Populations;walkability;Wildfire;Work;World Health;World Trade Center exposure

PROJECT_TITLE: Cardiometabolic diseases in the World Trade Center general responder cohort and the role of subsequent environmental exposures


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Pulmonary Hypertension

ORG_CITY: MIAMI

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE. Pulmonary arterial hypertension (PAH) is characterized increased lung vascular resistance, leading to right heart failure and death. Our proposal builds upon prior work implicating metabolic reprogramming in pulmonary artery smooth muscle cell in the development of pulmonary hypertension (PH). Further, we will evaluate novel therapies for treating these critically ill individuals.

PI_NAMEs: BLACK, STEPHEN M (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Apoptosis;Attenuated;Biochemical;Bioenergetics;Biological Assay;Biophysics;Blood Vessels;Calpain;Cell Proliferation;Cell Separation;Cessation of life;Complex;Critical Illness;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;Data;Development;Disease;Electron Transport;Failure;Hematological Disease;hypertensive;Impairment;Incubated;Individual;inhibitor;Inner mitochondrial membrane;innovation;Investigation;Knowledge;Lead;Link;Lung;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;Methodology;Methylation;Methyltransferase;Mitochondria;Mitochondrial complex I deficiency;Mitochondrial Proteins;Modeling;Molecular;Molecular Chaperones;Monocrotaline;mortalin;Motor;mutant;N-terminal;NADH dehydrogenase (ubiquinone);nitration;novel;novel therapeutic intervention;novel therapeutics;Obstruction;Pathogenesis;Peptides;pharmacologic;Phenotype;Phosphorylation;Phosphorylation Site;Play;pre-clinical;Pre-Clinical Model;prevent;Proliferating;protein distribution;Protein Import;Proteins;Proteolysis;Proteome;Publishing;pulmonary arterial hypertension;Pulmonary artery structure;Pulmonary Hypertension;Rattus;right ventricular failure;Right Ventricular Hypertrophy;Rodent Model;Role;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Testing;Therapeutic;Therapeutic Agents;therapeutic target;translocase;Treatment Efficacy;Vascular resistance;Work

PROJECT_TITLE: Metabolic reprogramming of smooth muscle cells in pulmonary hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Colorectal cancer (CRC) disproportionately affects rural areas, where CRC screening falls far below national guidelines. Although evidence-based CRC interventions exist, many rural primary care practices have not implemented these interventions. Therefore, in partnership with the Indiana Rural Health Association, we propose a study to test implementation of an evidence-based CRC intervention into primary care practices to increase CRC screening and support future implementation.

PI_NAMEs: CHAMPION, VICTORIA LEE (contact);DAMUSH, TERESA M.;IMPERIALE, THOMAS F.

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Adoption;Affect;budget impact;Cancer Etiology;Cancer Intervention;Cessation of life;Clinic;Clinical;Colonoscopy;Colorectal Cancer;colorectal cancer screening;contextual factors;cost;cost effective;cost estimate;cost outcomes;cost-effectiveness evaluation;Data;Diagnostic;Dose;educational atmosphere;Effectiveness;effectiveness evaluation;effectiveness outcome;evidence base;Evidence based intervention;experience;falls;future implementation;Goals;Guidelines;Health Services;Immunologic Tests;implementation evaluation;implementation facilitation;implementation outcomes;implementation process;implementation strategy;improved;Incidence;Indiana;Individual;innovation;Intervention;Interview;Knowledge;Maintenance;Measures;Modeling;mortality;Outcome;patient navigation;Patients;Persons;Physicians;Policies;Preparation;primary care practice;Promoting Action on Research Implementation in Health Services framework;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;Resolution;response;Risk;Rural;rural area;Rural Health;rural health clinic;rural setting;screening;Specialist;Test Result;Testing;treatment as usual;uptake;Variant

PROJECT_TITLE: Implementing evidence based colorectal cancer screening in rural clinics

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases;Schizophrenia

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative The intractable amotivation symptom in schizophrenia generates a debilitating condition with a substantial public health burden due to a lack of mechanistic understanding of the underlying neural circuits. The proposed research will use a genetic mouse line to selectively isolate and pinpoint a novel circuit that underlies the amotivation phenotype. The results of these experiments are positioned to provide a circuit-specific mechanism that can be manipulated to help inform therapeutic strategies to alleviate amotivation in patients.

PI_NAMEs: PATTON, MARY H. (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: addiction;Animals;Behavior;Behavioral;career;Categories;Cell Nucleus;cell type;Cells;cholinergic;Cholinergic Receptors;Cognitive;Complex;Corpus striatum structure;Coupled;Data;DiGeorge Syndrome;Dopamine D1 Receptor;Dopamine D2 Receptor;Dorsal;effective therapy;Electrophysiology (science);Exhibits;experimental study;Genetic;Genetic Diseases;Goals;Grant;Health Care Costs;Hyperactivity;Image;Implant;improved;in vivo;Individual;insight;Interneurons;Investigation;Learning;lens;Link;Location;Mental Depression;Mental disorders;motivated behavior;Motivation;mouse model;Mus;Muscarinic M2 Receptor;neural;neural circuit;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;novel;Occupational;optogenetics;Parafascicular Nucleus;patch clamp;Pathogenicity;Pathway interactions;Patients;Phenotype;Positioning Attribute;presynaptic;programs;Psychological reinforcement;Public Health;Quality of life;Receptor Activation;Research;Rewards;Role;Schizophrenia;Severities;Signal Transduction;social;Symptoms;Synapses;Synaptic Transmission;Thalamic Nuclei;Thalamic structure;Therapeutic;Training;transmission process;Wild Type Mouse

PROJECT_TITLE: A novel circuit underlying amotivation in a mouse model of 22q11DS


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Residual cardiovascular disease (CVD) risk in patients on lipid lowering therapy is a major unmet clinical need. Our goal is to investigate mechanisms of plaque stabilization and destabilization focused on functions of vascular smooth muscle cell (SMC) derived cells (SDCs), and their crosstalk with macrophages (Mϕ), in mouse models and human CVD. Our work will provide mechanistic insight into the role of SDC types, their lesion domain locations and neighboring cells, and crosstalk with Mϕ to achieve our overall goal of greater mechanistic understanding of factors affecting atherosclerotic plaque stability and instability.

PI_NAMEs: REILLY, MUREDACH P (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: 8-Oxoguanine DNA Glycosylase;Acceleration;Affect;Arterial Fatty Streak;atheroprotective;Atherosclerosis;Attenuated;biobank;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;Cell Lineage;Cell Physiology;cell type;Cells;Clinical;clinically relevant;Coupled;Data;Diphtheria Toxin;Disease Progression;Disease regression;DNA;DNA glycosylase;epigenetic marker;Etiology;Fibroblasts;Functional disorder;Genes;Genetic;Genetic Diseases;Genetic Variation;Goals;Histology;Human;Impairment;in situ sequencing;Inflammasome;Inflammatory;insight;Lesion;Lipids;Location;Low-Density Lipoproteins;Macrophage;Modeling;mouse model;Multiomic Data;multiple omics;Necrosis;novel;novel therapeutic intervention;oxidative DNA damage;Patients;Pilot Projects;Regulator Genes;Residual state;Resolution;Resources;RNA;Role;Shoulder;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Source;spatial integration;Stable Disease;Testing;transcriptome sequencing;Transgenic Mice;Transgenic Model;Translations;Tretinoin;Variant;Vascular Smooth Muscle;Work

PROJECT_TITLE: Smooth muscle cell-derived cell fates and cellular interactions in atherosclerotic plaque stability in disease progression and regression.

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The goal of this proposal is to establish the University of Iowa as a translational research infrastructure to efficiently conduct rigorous and innovative comparative studies of cerebroprotection in the context of reperfusion, in collaboration with the NIH Stroke Preclinical Assessment Network (SPAN). The goal is to identify which cerebroprotective treatments are likely to improve the outcomes of the 800,000 Americans who suffer a stroke and are currently treated with reperfusion strategies that have limited effectiveness.

PI_NAMEs: CHAUHAN, ANIL KUMAR;LEIRA, ENRIQUE CARLOS (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Acute;Address;adjudication;Adjuvant Therapy;Alteplase;American;animal care;Animals;Artificial Intelligence;Assessment tool;behavioral outcome;Blinded;Blood Vessels;central database;cerebroprotection;cerebrovascular;Classification;Clinical;Clinical Trials;Clinical Trials Network;Coagulation Process;Collaborations;comorbidity;Comparative Study;Computing Methodologies;Consensus;cost;Data;design;Development;Effectiveness;Enrollment;Environment;Enzymes;Epidemiology;experience;Experimental Designs;Experimental Models;Filament;Frequencies;functional improvement;Future;Goals;improved;improved outcome;in vivo;Industry;Infrastructure;innovation;Institution;Intention;Intervention;Iowa;Ischemia;Ischemic Stroke;Logistics;Metabolic;Methodology;Mission;Modeling;neuroimaging;Neurology;Outcome;Outcome Measure;Participant;Patients;Pattern;Performance;Positioning Attribute;post stroke;pre-clinical;pre-clinical assessment;Protocols documentation;Pyruvate Kinase;Randomized;Reperfusion Therapy;Reporting;Research;Research Infrastructure;Rodent;Rodent Model;Role;sex;Site;Speed;Stroke;stroke intervention;stroke model;stroke therapy;StrokeNet trials;Survival Rate;Technical Expertise;Testing;thromboinflammation;Thrombosis;Thrombus;Translational Research;translational scientist;translational study;United States National Institutes of Health;Universities;Uric Acid;vibration;Walking

PROJECT_TITLE: The University of Iowa Stroke Preclinical Assessment Network to Support Translational Studies for Acute Cerebroprotection


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative Chronic pain afflicts millions of patients; yet, treatments are largely ineffective and development of new, targeted therapies is limited by gaps in our knowledge regarding its underlying neural circuitry. This project will investigate a group of neurons that we recently discovered and that we propose represent an important component of descending pain modulation circuitry. Defining fundamental characteristics of this novel descending pathway involved in pain modulation, including its functional connectivity, synaptic mechanisms and its role in acute and chronic pain states, will ultimately help to better understand the neural circuitry of pain and may lead to more efficacious and better targeted therapeutics for treating acute and chronic pain.

PI_NAMEs: BASSUK, ALEXANDER G;USACHEV, YURIY M (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acute Pain;Address;Affect;Analgesics;antinociception;Attenuated;Axon;Behavior;behavior test;C Fiber;Capsaicin;Cells;Characteristics;chronic pain;Clozapine;Complex;Data;Designer Drugs;Development;dorsal horn;Genetic;genetic approach;genetic manipulation;Glutamate Decarboxylase;Hypersensitivity;Image;Inflammation;Inflammatory;inflammatory pain;Injections;innovation;interdisciplinary approach;Knowledge;Label;Lateral;Mechanics;Mediating;midbrain central gray substance;Modeling;mouse model;multi-photon;nerve injury;neural circuit;Neurobiology;Neurons;Neuropathy;Nociception;noradrenergic;novel;optogenetics;Output;Oxides;Pain;Pain management;pain processing;painful neuropathy;parabrachial nucleus;patch clamp;Pathway interactions;Patients;Persistent pain;Phase;Play;Pontine structure;Pre-Clinical Model;Preparation;presynaptic;prodynorphin;Regulation;Role;Signal Transduction;spared nerve;Spinal;Spinal Cord;Spinal cord posterior horn;Synapses;Synaptic Transmission;targeted treatment;Testing;two-photon;Tyrosine 3-Monooxygenase;Work

PROJECT_TITLE: Novel Circuits and Mechanisms of Descending Pain Modulation

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative The proposed research aims to establish senescent regulatory T cells as the cellular target for renal clear cell carcinoma by using Proteolysis targeting chimera (PROTAC) technology that leads to the degradation of pro- survival BCL-XL protein. We have found that BCL-XL PROTAC can induce the apoptosis of tumor-infiltrating Tregs. Using in vivo models and cancer specimens, we will determine the efficacy of senolytic targeting BCL-XL by combining with other frontline therapeutics and provide a rationale to target BCL-XL for cancer immunotherapy for renal cell carcinomas.

PI_NAMEs: ZHANG, WEIZHOU  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Age;Aging;aging population;aging related;angiogenesis;antiangiogenesis therapy;Autoimmunity;bcl-xlong protein;BCL2L1 gene;beta-Galactosidase;Blood;cancer immunotherapy;Cancer Model;Cancer Patient;cancer therapy;cancer type;carcinogenesis;CD8-Positive T-Lymphocytes;Cell Aging;Cell Proliferation;Cells;cellular targeting;checkpoint therapy;Chemicals;chemotherapy;Chronic;Clear cell carcinoma;Clear cell renal cell carcinoma;Clinical;Conventional (Clear Cell) Renal Cell Carcinoma;Data;design;Development;Developmental Process;Diagnosis;drug development;Drug resistance;effector T cell;efficacy evaluation;Exhibits;fighting;Genetic;Histologic;Human;human RNA sequencing;Immune;immune cell infiltrate;Immune checkpoint inhibitor;immunoregulation;immunosenescence;Immunosuppression;In complete remission;in vivo;in vivo Model;Induction of Apoptosis;Infiltration;Kidney;Label;Lead;Literature;Malignant Epithelial Cell;Malignant Neoplasms;man;multicatalytic endopeptidase complex;Mutation;Neoplasm Metastasis;normal aging;novel;novel therapeutic intervention;Oncogene Activation;Oncogenes;Organ;Outcome;Pathogenesis;Patients;Pharmaceutical Preparations;Play;Population;prevent;Process;Prognosis;prognosis biomarker;Protac;Publications;Radiation therapy;rational design;Regimen;Regulatory T-Lymphocyte;Renal Carcinoma;Renal Cell Carcinoma;Reporting;Research;Resistance;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;single-cell RNA sequencing;Specimen;T cell infiltration;Technology;Therapeutic;Therapeutic Intervention;Tracer;Treatment Efficacy;Treatment Protocols;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;tumor-immune system interactions;ubiquitin-protein ligase;Ubiquitination;Update;Woman;Work

PROJECT_TITLE: Exploring novel therapeutic strategies for combinatory therapy to treat renal clear cell carcinomas

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative GSTP1 is uniquely downregulated in luminal and some Her2-positive breast cancers. This proposal will explore whether epigenetic silencing of GSTP1 makes BRCA sensitivity redox-based therapy and delineate the molecular consequences of its repression.

PI_NAMEs: HELD, JASON M. (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: acetovanillone;acquired treatment resistance;Affect;anti-cancer;Antioxidants;Biological;Biological Assay;Biological Markers;Biology;Breast Cancer Cell;Breast Cancer cell line;Cancer cell line;Cancer Patient;cancer subtypes;cancer type;candidate identification;candidate marker;Cell Line;Cells;Cessation of life;Chemistry;Clinic;Clinical;Clinical Trials;Complement;Complex;Cysteine;cysteinesulfenic acid;Disease;disulfide bond;ebselen;Electrons;Endocrine;Enzymes;epigenetic regulation;epigenetic silencing;Evaluation;Glutathione;glutathione S-transferase pi;Growth;In Vitro;in vivo;inhibitor;insight;interest;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant Neoplasms;Metabolic;Modality;Modeling;Molecular;molecular marker;mRNA Expression;NADPH Oxidase;Neoplasm Metastasis;novel;novel marker;Oncogenic;Organoids;overexpression;oxidation;Oxidation-Reduction;Pathway interactions;patient derived xenograft model;Patients;pharmacodynamic biomarker;Phenotype;predictive marker;prognostic;protein expression;protein function;protein protein interaction;protein structure;Proteins;Proteome;Regulation;Relapse;Reporting;Repression;Resistance;Role;sensor;Sentinel;Signal Transduction;Signaling Protein;small molecule;Techniques;Testing;Therapeutic;transcriptomics;Treatment Efficacy;tumor;tumorigenesis;Up-Regulation

PROJECT_TITLE: Investigating GSTP1 as a novel regulator of the cysteine redoxome in breast cancer and maker of vulnerability to redox-based therapy


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative Heart attacks result from changes within the walls of arteries (blood vessels) in the heart. We know that when the inner lining of an artery is damaged, a blood clot sometimes forms and blocks the vessel severely enough to cause a heart attack. At other times, however, through processes that are not well-understood, the damage to the lining is repaired spontaneously, clot formation is prevented, and no heart attack occurs. The studies we propose here are designed to understand processes and factors that affect repair of the inner lining of the vessel, so we can use this knowledge to prevent or reduce the occurrence of heart attacks.

PI_NAMEs: RIASCOS BERNAL, DARIO FERNANDO (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;acute coronary syndrome;Address;Affect;angiogenesis;Anti-Inflammatory Agents;Antioxidants;Area;Arterial Fatty Streak;Arteries;Atherosclerosis;atherosclerotic plaque rupture;Blood coagulation;Blood Vessels;Carotid Arteries;Cause of Death;Cell Death;cell growth;Cell Line;cell motility;Cell Physiology;Cell Proliferation;Cell Respiration;Cell Survival;Cellular Metabolic Process;Cessation of life;Clinical;Clinical Trials;Closure by clamp;Coagulation Process;comparative;Complex;Coronary;Coronary Arteriosclerosis;Coronary heart disease;Data;design;Development;Endothelial Cells;endothelial repair;Endothelium;Equilibrium;Evaluation;Event;extracellular;Functional disorder;Genetic;healing;Heart;Heart Diseases;Homeostasis;Human;human migration;Hyaluronan;Hyperglycemia;Hyperlipidemia;Impairment;improved;In Vitro;Incidence;Inflammatory Infiltrate;Injury;injury and repair;innovation;Intrinsic factor;Knowledge;mature animal;Metabolism;metabolomics;Methods;migration;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular;Molecular and Cellular Biology;molecular phenotype;monolayer;mouse genetics;Mus;Myocardial Infarction;NADH;NADH dehydrogenase (ubiquinone);Natural regeneration;neutrophil;Outcome;Oxygen Consumption;pharmacologic;Predisposition;prevent;Process;Production;Proliferating;Recovery;repaired;Research Project Grants;Research Proposals;Respiration;Rupture;Site;stem;Surface;Testing;three-dimensional visualization;Thrombosis;thrombotic;Toll-like receptors;tool;United States

PROJECT_TITLE: Endothelial Cell Respiration in Atherosclerotic Plaque Erosion


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Genetics;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Pontocerebellar hypoplasia (PCH), a severe neurological disorder for which there is no cure that is caused by mutations in several RNA processing complexes. The aims of this proposal will determine how several PCH-linked complexes assemble, recognize and process RNA, how they are enzymatically and spatially regulated, and how PCH mutations disrupt their function. This work is essential to better understand how these complexes function normally in healthy states and how their dysfunction leads to PCH.

PI_NAMEs: HAYNE, CASSANDRA K (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Binding;Biochemical;Biological;biological adaptation to stress;Biological Assay;Biology;cell growth regulation;Cell Physiology;Cells;Cessation of life;circular RNA;Complement;Complex;crosslink;Cryoelectron Microscopy;Defect;Development;Disease;endonuclease;Engineering;Exonuclease;Family;Fluorescence Microscopy;Functional disorder;Genetic;Goals;Health;Human;human disease;Hydroxyl Radical;In Vitro;insight;Introns;Lead;Left;Link;link protein;Mass Spectrum Analysis;Microscopy;Molecular;Molecular Biology;mutant;Mutation;Nervous System Disorder;Neurodegenerative Disorders;Neurodevelopmental Disorder;Nuclear;nuclease;Pathway interactions;Polynucleotide 5'-Hydroxyl-Kinase;Pontocerebellar hypoplasia;prenatal;prevent;Process;Production;protein complex;protein function;protein protein interaction;Proteins;Proteomics;Protocols documentation;reconstitution;Regulation;Research Personnel;RNA;RNA Binding;RNA Processing;RNA Splicing;Role;Small Nuclear RNA;Substrate Specificity;Surface;Techniques;Therapeutic;transcriptome sequencing;Transfer RNA;Untranslated RNA;Validation;Work;Yeasts

PROJECT_TITLE: Structural and Functional Characterization of Pontocerebellar Hypoplasia Associated Nucleases

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SAN ANTONIO

ORG_NAME: SOUTH TEXAS VETERANS HEALTH CARE SYSTEM

ORG_STATE: TX

PHR: The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery. This research is especially relevant to older Veterans as two-thirds of Veterans are overweight or obese, rendering excess adiposity a significant risk factor and a high- priority area related to COVID-19 prevention and care. This study also will explore potential mechanisms by which systemic and adipose tissue inflammation and senescence influences the pathophysiology of physical, mental, and social dysfunction in older Veterans recovering from COVID-19. Our findings could lead to novel lifestyle and pharmacologic strategies to optimize COVID-19 recovery.

PI_NAMEs: RYAN, ALICE S.;SERRA, MONICA C (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Adipose tissue;Aerobic;aging related;aging related disease;Area;Baltimore;Behavioral;Biological Assay;Biology of Aging;Body Composition;Body Weight;Caring;Cell Aging;Cell Cycle Arrest;Cell Physiology;Cells;Chronic;clinical implementation;cohort;COVID-19;COVID-19 impact;COVID-19 prevention;cytotoxicity;Diet Modification;disability;Dual-Energy X-Ray Absorptiometry;Dyspnea;ethnic diversity;Etiology;evidence based guidelines;Exercise;Fatigue;Fatty acid glycerol esters;functional decline;Functional disorder;Gait speed;Health;health related quality of life;improved;Individual;Inflammation;Inflammatory;innovation;insight;Intervention;Intramuscular;Laboratories;Life Style;lifestyle intervention;Long COVID;Medical center;men;Metabolic dysfunction;Molecular Profiling;Muscle Weakness;novel;Obesity;Outcome;Overweight;Oxidative Stress;Pain;Participant;Patient Self-Report;persistent symptom;pharmacologic;Phenotype;physical conditioning;Physical Function;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID conditions;post-COVID-19;Predisposing Factor;Prevention;primary outcome;Psyche structure;Randomized;Randomized, Controlled Trials;Recovery;recruit;Rehabilitation therapy;Reporting;Research;response;Risk;Risk Factors;Role;Sampling;SARS-CoV-2 infection;Scanning;senescence;senescence associated secretory phenotype;senescent cell;social deficits;Symptoms;Testing;Thinness;Tissue Banks;Tissues;United States National Institutes of Health;Variant;Veterans;Visceral fat;VO2max;Walking;Weight;weight loss intervention;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

ORG_STATE: MA

PHR: Cognitive aging, characterized by declines in memory and thinking abilities, is one of the most important issues facing older Veterans. As the Veteran population ages, the number of Veterans at risk for cognitive decline increases. Veterans are also more likely to have psychological, physical, and social conditions directly tied to their service that increase their risk for cognitive decline. Luckily, over the past two decades there has been an increased appreciation for the role of lifestyle interventions to improve brain health, with research showing that participation in consistent exercise, healthy diet, sufficient sleep, socialization, and engagement in cognitively stimulating activities can reduce dementia risk. The goal of this project is to determine the effect of a multi- component intervention designed to provide education about brain aging, improve feelings of control over brain aging, and deliver practical assistance with creation of an executable action plan. These types of interventions are are critically needed to improve the brain health of aging Veterans.

PI_NAMEs: O'CONNOR, MAUREEN KATHELEEN (contact)

PROJECT_TERMS: Affective;Age;age effect;age related cognitive change;Aging;aging brain;Anxiety;Area;Attitude;behavior change;Biological Markers;Brain;Brain Diseases;brain health;Brain region;Caring;Clinical Services;Coffee;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive testing;comparison control;Control Groups;Dementia;dementia risk;Diet;Education;Educational process of instructing;evidence base;Exercise;Feeling;follow-up;Foundations;Friends;Funding;General Population;Genetic;Goals;good diet;Growth;health plan;Health Services;Health system;healthy lifestyle;Home;Housing;human old age (65+);Impaired cognition;improved;Individual;innovation;Integrated Health Care Systems;Intervention;late life;Learning;Life;Life Style Modification;lifestyle factors;lifestyle intervention;Literature;Loneliness;Meaning and purpose;Memory;Mental Depression;Methods;military veteran;multi-component intervention;neuroimaging;Participant;Patient Self-Report;Perception;Pilot Projects;programs;psychologic;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Research;Risk;Risk Factors;Role;Self Efficacy;Services;skills;Sleep;social;Social Conditions;Socialization;Strategic Planning;stress reduction;Techniques;therapy design;Thinking;Veterans;Vision;Well in self;whole health

PROJECT_TITLE: Aging Well through Interactions and Scientific Education - Action Plan (AgeWISE-AP)


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Hydrocephalus;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke;Unintentional Childhood Injury

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Many premature infants suffer brain injury due to bleeding within the fluid-filled spaces of the brain that occurs shortly after birth. Currently there is no medical therapy to reduce brain injury in these children. This study will examine the causes of this neonatal brain injury and test therapies to reduce the injury.

PI_NAMEs: MILLER, BRANDON A (contact)

PROJECT_TERMS: Adult;Affect;Animals;Anti-Inflammatory Agents;Antibiotics;Antibodies;Azithromycin;Birth;blood product;Bone Marrow;Brain;brain cell;Brain Injuries;Bromodeoxyuridine;Cd68;Cell Communication;Cell Death;Cell division;Cell Maturation;cell type;Cells;Central Nervous System Diseases;central nervous system injury;Cerebral Palsy;Cerebral Ventricles;chemokine;Child;Childhood Injury;Clinical;Clinical Research;Clinical Trials;Cognitive deficits;cytokine;Data;Development;Dichloromethylene Diphosphonate;Disease;efficacy evaluation;excitotoxicity;experimental study;Failure;functional improvement;Goals;Hematogenous;Hemoglobin;Hemorrhage;Hydrocephalus;Immunochemistry;Immunohistochemistry;improved;improved outcome;In Vitro;in vitro Model;in vivo;Infiltration;Inflammation;Inflammatory;Injections;Injury;Interruption;Intraventricular;intraventricular hemorrhage;lateral ventricle;Lifelong disability;Liquid substance;lung injury;Macrophage;Macrophage Activation;Maps;Measures;Mediating;Medical;Messenger RNA;Microglia;Modeling;monocyte;mRNA Expression;Myelin;Myelin Basic Proteins;myelination;Myelogenous;Neonatal;neonatal brain;Neonatal Brain Injury;neonate;Nervous System Disorder;Nervous System Physiology;neurobehavioral;neuroinflammation;Neurological outcome;NF-kappa B;Nucleic Acids;oligodendrocyte progenitor;Oligodendroglia;Outcome;Oxidative Stress;Peripheral;Pharmaceutical Preparations;pharmacologic;Phenotype;postnatal;pre-clinical;Premature Birth;Premature Infant;preservation;Process;Production;Property;protein expression;Rattus;Recovery;recruit;repaired;response;Role;self renewing cell;Site;Spinal cord injury;stem cell fate;stem cell survival;stem cells;Stimulus;Testing;Therapeutic;Time;Tissues;TNF gene;Training;Ventricular;Western Blotting;white matter;white matter injury;Work

PROJECT_TITLE: Reversing Inflammatory Macrophage Activation as Treatment for Neonatal Intraventricular Hemorrhage and Hydrocephalus

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ORG_CITY: RICHMOND

ORG_NAME: VA VETERANS ADMINISTRATION HOSPITAL

ORG_STATE: VA

PHR: Veterans with post-traumatic stress disorder (PTSD) can develop liver cirrhosis due to alcohol and substance abuse. PTSD and cirrhosis often co-exist, but research on these conditions has progressed separately till now. These conditions are also associated with changes in gut microbes, which can affect the brain negatively. We propose as part of a collaboration of several proposals entitled “Targeting Gut-Microbiome in Veterans Deployment related Gastrointestinal and Liver diseases” to study changes in the gut microbes as a potential treatment target in Veterans with cirrhosis and PTSD. We will perform this by enrolling 320 Veterans from two large VA sites, 80 each of whom will be healthy, 80 will have PTSD only, 80 with cirrhosis only and 80 with PTSD+Cirrhosis. We will study their gut microbes, which will be linked to brain function, and severity of PTSD symptoms. For the second aim, we will transfer stool from affected Veterans into germ-free mice to define which microbes are responsible for the gut, liver and brain changes and can be specifically targeted.

PI_NAMEs: BAJAJ, JASMOHAN S (contact)

PROJECT_TERMS: addiction;Address;Affect;Alcohol abuse;Award;Behavior;Bile Acids;Brain;brain dysfunction;Chronic stress;Cirrhosis;Cognition;Collaborations;cytokine;Data;Development;diarrheal disease;Disease;dysbiosis;Encephalitis;Enrollment;experience;Fatty Acids;fecal transplantation;Feces;Functional disorder;Gastrointestinal Diseases;Genes;Germ-Free;Gnotobiotic;Goals;gut dysbiosis;gut inflammation;gut microbes;gut microbiome;gut microbiota;health related quality of life;Hepatic Encephalopathy;Human;humanized mouse;Impaired cognition;Impairment;in vivo Model;Incidence;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory milieu;intestinal barrier;Intestines;Investigation;Knowledge;Lead;Link;lipopolysaccharide-binding protein;Liver;Liver Cirrhosis;Liver diseases;Los Angeles;Mediating;Metagenomics;Microbe;microbial;microbial based therapy;microbiome;microbiome analysis;microbiota;military veteran;Modality;Modeling;mouse model;Mus;neuroinflammation;novel;novel therapeutics;Organ;Outcome;pathobiont;Patient Outcomes Assessments;Patient Transfer;Persian Gulf Syndrome;Pharmaceutical Preparations;Phase;Plasma;Post-Traumatic Stress Disorders;Predisposition;Process;Publishing;Quality of life;randomized trial;Research;resilience;Role;Safety;Serum;Severities;Site;Source;Stress;stress resilience;Structure;Substance abuse problem;success;Symptoms;systemic inflammatory response;targeted treatment;Technology;Testing;transcriptome sequencing;translational impact;Transplantation;Veterans;Volatile Fatty Acids

PROJECT_TITLE: BCCMA: Targeting Gut Microbiome in Gastrointestinal and Liver Diseases in US Veterans; CMA4: At the Crossroads of the Gut Microbiome, Cirrhosis, and PTSD


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Kidney Disease;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: PROJECT NARRATIVE Wilms tumor is the most common kidney cancer in children and accounts for 6% of pediatric cancer. Patients who have tumors with diffuse anaplasia (unfavorable histology) have dismal prognoses. The purpose of this project is to understand the fundamental biology of how WT1 functions as an oncogene in anaplastic Wilms tumor. This project could lead to new treatment strategies which directly or indirectly target WT1 in anaplastic Wilms tumor.

PI_NAMEs: MURPHY, ANDREW J (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: 17p13.1;Alleles;Anaplasia;Apoptosis;behavior in vitro;Binding;Biological Models;Biology;Biometry;cancer cell;Cancer Patient;career development;cell behavior;Cell Line;Cell Survival;Cells;Cessation of life;Chemicals;chemotherapy;Childhood Renal Neoplasm;Chromosomes;Code;combat;Complex;CRISPR/Cas technology;Cultured Tumor Cells;Data;demethylation;Detection;Diffuse;Disease;DNA;DNA Binding Domain;DNA Damage;Dominant-Negative Mutation;Dose;Enzymes;Epigenetic Process;epigenetic regulation;Evaluation;Event;Exhibits;experience;experimental study;Genetic;genetic manipulation;Genetic Transcription;Genomics;Germ-Line Mutation;Goals;high risk;high risk population;Histology;histone demethylase;Histones;Holoenzymes;Human;Impairment;improved;In Vitro;inhibitor;insight;knock-down;Knock-out;Libraries;loss of function;loss of function mutation;Malignant Childhood Neoplasm;Malignant childhood renal neoplasm;Mediating;Mentors;Microscopic;Modeling;mouse model;Mus;mutant;Mutation;neoplastic cell;Nephroblastoma;nephron progenitor;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Outcome;Outcome Study;overexpression;Pathway interactions;Patients;pre-clinical;pre-clinical therapy;Preclinical Testing;Prognosis;Proliferating;promoter;Proteins;Qualifying;Research;Resistance;Role;Sampling;small hairpin RNA;stem cells;Tamoxifen;targeted agent;targeted treatment;Telomerase;telomere;Telomere Maintenance;Telomere Shortening;TERT gene;Testing;therapeutic target;therapy resistant;TP53 gene;Training;transcription factor;Transgenic Mice;Transgenic Organisms;treatment strategy;tumor;Tumor Biology;Tumor Stem Cells;Tumor Suppressor Proteins;tumor xenograft;WAGR Syndrome;WT1 gene;Xenograft Model

PROJECT_TITLE: WT1 as an oncogene and therapeutic target in anaplastic Wilms tumor

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pregnancy;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Community pharmacies play an important role in the health care system: they are frequently accessed and have increasing capacity to deliver HIV prevention services. In communities where the prevalence of HIV is high and access to antenatal care clinics is delayed or infrequent, there is a unique opportunity to leverage pharmacies to enhance early and sustained access to HIV prevention among pregnant women. This study will identify women’s preferences for delivery of HIV prevention services and provider-level and system-level strategies to design a new pharmacy-based model of care for pregnant women.

PI_NAMEs: MUGAMBI, MELISSA  (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Administrator;Age;AIDS prevention;antenatal care;behavior change wheel;care systems;career;Caring;Catchment Area;chronic infection;Clinic;Communities;Community Pharmacy;Complement;Consensus;cost;cost efficient;cost estimate;Data;design;Development;Environment;Evaluation;experimental study;Face;First Pregnancy Trimester;Foundations;Future;Goals;Health;Health Services;Healthcare;Healthcare Systems;Hearing;HIV;HIV Infections;implementation cost;implementation intervention;implementation science;implementation strategy;Improve Access;improved;Intervention;intervention delivery;Interview;K-Series Research Career Programs;Kenya;Lead;Mentors;Methods;model design;Modeling;novel;older women;Oral;Patients;Pharmacy facility;pilot test;Play;pre-exposure prophylaxis;preference;Pregnancy;Pregnancy Tests;Pregnant Women;Prevalence;prevention service;preventive intervention;programs;Provider;Recommendation;Reporting;reproductive;Reproductive Health Services;Research;Research Personnel;Resources;Risk;Role;Scientist;screening;Solid;Structure;Subgroup;Surveys;System;Testing;Theoretical Domains framework;theories;Training;Universities;uptake;Vertical Disease Transmission;Visit;Washington;Woman;Work;World Health Organization

PROJECT_TITLE: The design and evaluation of strategies to implement HIV prevention interventions for pregnant women in community pharmacy settings

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Electronic Nicotine Delivery Systems;Maternal Health;Pediatric;Pregnancy;Prevention;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: DETROIT

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Narrative The U.S. Surgeon General recently announced the use (vaping) of electronic cigarettes (e-cigs) as a major public health concern. Utilizing a state-of-the-art custom-engineered vaping system with an atomizer identical to those sold in vape shops world-wide, the proposed studies discerning the health effects of e-cigs during pregnancy will allow effective education of the public and will facilitate applicable policy implementation regarding the potential risks these devices pose to the public. The proposed studies directly address a stated consensus recommendation of the most recent NIH/NHLBI workshop on cardiovascular disease and the emergence of e-cigs, i.e. investigating effects of e-cigarette aerosol exposure in pregnant women.

PI_NAMEs: RAMADOSS, JAYANTH  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Arteries;Arteriographies;Atomizer;base;Birth Weight;Blood flow;Blood Pressure;Blood Vessels;Cardiac Output;Cardiovascular Diseases;Cardiovascular system;Catheterization;Chemicals;combustible cigarette;commercialization;Consensus;Custom;Data;design;Devices;Dose;e-cigarette aerosols;Educational workshop;Electrocardiogram;Electronic cigarette;electronic cigarette use;Endothelium;Engineering;Enzymes;Epoprostenol;exposed human population;fetal;Fetal Development;Fetal Growth;Fetal Growth Retardation;Fetal health;Fetus;Frequencies;frontier;Gases;General Population;Glycerol;Health;hemodynamics;High Pressure Liquid Chromatography;Histologic;Human;Impairment;indexing;Inhalation;Knowledge;Liquid substance;Lung;Maternal Health;Methods;Microspheres;Modeling;Molecular;Mothers;National Heart, Lung, and Blood Institute;Neonatal;Nicotine;Nitric Oxide;NOS3 gene;Nutrient;Operative Surgical Procedures;Outcome;Oxygen;Pathway interactions;pharmacologic;Policies;Positioning Attribute;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;pressure;Production;Propylene Glycols;protein expression;public education;Public Health;Rattus;Recommendation;Relaxation;reproductive;Research;response;Risk;Signal Transduction;Smoking;Surgeon;System;Technology;Testing;Tobacco use;tobacco user;tool;transcriptome;Ultrasonography;United States National Institutes of Health;Uterus;vaping;vapor;Vascular Diseases;vascular injury;Vasodilator Agents;Western Blotting;Woman

PROJECT_TITLE: ELECTRONIC CIGARETTE VAPING & VASCULAR SEQUELAE IN THE UTERUS DURING  PREGNANCY.

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_DEPT: GENETICS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Hepatocellular carcinoma (HCC) is an extremely aggressive and invariably fatal cancer with no currently effective treatment for advanced disease. The proposal aims at analyzing the molecular mechanisms by which two interacting oncogenes, AEG-1 and MDA-9, cooperate to promote HCC, and evaluate combination of AEG-1 and MDA-9 inhibition as preventive and therapeutic approaches for HCC.

PI_NAMEs: FISHER, PAUL B;SARKAR, DEVANAND  (contact)

PROJECT_TERMS: advanced disease;angiogenesis;Animal Model;Astrocytes;Automobile Driving;BAY 54-9085;c-myc Genes;Cancer Etiology;Cell membrane;Cessation of life;Clinical;clinical application;Clinical Trials;combinatorial;Databases;Dependence;Development;Diethylnitrosamine;effective therapy;EGFR Protein Overexpression;Epidermal Growth Factor Receptor;Evaluation;expectation;FDA approved;Genes;Growth;Hepatocarcinogenesis;Hepatocyte;Human;Immunocompetent;In Vitro;in vivo Model;inhibitor;innovation;insight;Invaded;Investigational Therapies;Knock-out;Knockout Mice;Knowledge;liver cancer model;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Melanoma differentiation associated gene-9;Membrane;Methodology;Molecular;Monitor;mouse model;Mus;nano;nanoparticle delivery;Neoplasm Metastasis;novel;Nude Mice;Oncogenes;Oncogenic;overexpression;Pathogenesis;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phase I/II Clinical Trial;Phenotype;Play;Pre-Clinical Model;Preventive;Primary carcinoma of the liver cells;Property;Proteins;Protocols documentation;Research;RNA Interference Therapy;Role;Scaffolding Protein;Seminal;Signal Transduction;Small Interfering RNA;small molecule inhibitor;System;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Uses;therapeutically effective;trafficking;Transgenic Mice;Transgenic Organisms;Translations;Treatment Efficacy;tumorigenic;Unresectable;Work;Xenograft procedure

PROJECT_TITLE: Novel Targeted Combinatorial Therapy for Hepatocellular Carcinoma


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE HIV prevention and care interventions, including Pre-exposure Prophylaxis (PrEP), could effectively end the HIV epidemic, however, more research and training focused on implementation strategies to ensure PrEP is implemented effectively in public clinics is needed. This K24 provides protected time to Dr. Lippman to extend her current implementation research, broaden her mentoring program, and expand opportunities for early career investigators to engage in cutting edge implementation science research to address barriers to PrEP delivery in South Africa and Brazil. This work can improve PrEP delivery for health disparity populations with poor access to tailored HIV prevention and ensure a pipeline of trainees in the US and abroad who are well equipped in the application of implementation science approaches to stimulate new research and independent research careers.

PI_NAMEs: LIPPMAN, SHERI ANN (contact)

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: acceptability and feasibility;Address;AIDS prevention;Area;barrier to care;Behavior Therapy;Brazil;Breathing;care delivery;career;Caring;Clinic;Clinical;clinical practice;Collaborations;Communities;Community Health Aides;community living;Community-Based Distributions;community-level factor;Competence;Complex;Consolidated Framework for Implementation Research;Country;Dedications;Disparity;Disparity population;Dose;Ensure;Environment;Epidemic;Equity;Evidence based intervention;experience;Female Adolescents;gender affirming care;Health;health disparity populations;Health Priorities;Health Services Accessibility;Health system;HIV;HIV disparities;Human immunodeficiency virus test;implementation context;implementation research;implementation science;implementation strategy;implementation study;improved;Incidence;Individual;Infrastructure;Institution;Intervention;intervention delivery;Leadership;Learning;Maintenance;Maps;member;men who have sex with men;Mentors;Methods;mid-career faculty;Monitor;next generation;Oral;patient oriented research;Patients;personalized approach;Policies;Population;Population Group;Populations at Risk;pre-exposure prophylaxis;prevent;Prevention;primary care clinic;Process;programs;Provider;rapid technique;Recommendation;Research;Research Personnel;research to practice;residence;Resources;Risk;routine practice;rural health clinic;rural South Africa;Science;Scientific Inquiry;Scientist;service delivery;Services;sexual and reproductive health;Shapes;Site;skills;social;social structure;South Africa;South African;State Interests;structural determinants;Structure;Taxonomy;therapy development;Time;tool;Training;training opportunity;transgender women;Translating;Translations;United States National Institutes of Health;uptake;Work;working group;young woman

PROJECT_TITLE: Training in implementation science research to improve PrEP services for people at risk for HIV


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The current and future shortage of cardiothoracic surgeons and the extremely diverse clinical activities and broad array of conditions treated by cardiac and thoracic surgeons is an emergent unmet need that demands a training program in cardiothoracic surgery. To meet this need, it is imperative that we provide and expand the necessary training of cardiothoracic surgeons to replenish the workforce pipeline and foster sustained development of academically-bound cardiac and thoracic surgeons.

PI_NAMEs: LUKETICH, JAMES D (contact);PHILLIPPI, JULIE A;VORP, DAVID ALAN

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: surgical research;Training Programs

PROJECT_TITLE: Cardiothoracic Surgery Research Training Program


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Lyme disease, caused by the spirochete Borrelia burgdorferi, is associated with a spectrum of clinical symptoms and a dramatic range in severity among infected individuals. A forward genetics approach identified a locus on Chr 4 of the mouse that regulates Lyme arthritis by controlling the expression of Type I IFN, and downstream induction of MSTN as an effector of arthritis development. The mechanism by which Type I IFN and MSTN contribute to Lyme arthritis development will be addressed, with the goal of identifying novel therapeutic targets for patients with severe disease.

PI_NAMEs: WEIS, JANIS J. (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Address;Alleles;Arthritis;BCL6 gene;bone;Bone Density;Borrelia burgdorferi;C57BL/6 Mouse;Carditis;CDKN2A gene;Cells;Chromosome Mapping;Chromosomes;Chronic Disease;Clinical;Complex;congenic;Congenic Mice;Cyclin-Dependent Kinases;Development;Disease;experimental study;Fatigue;forward genetics;GDF8 gene;Gene Cluster;Gene Expression;Gene Silencing;Genes;Genetic;genetic approach;genetic element;Genetic Polymorphism;Goals;Human;Immune response;In Vitro;in vitro testing;in vivo evaluation;Inbred C3H Mice;Individual;Infection;Inflammation;inhibitor;insight;Interferons;joint function;Joints;Knockout Mice;Link;Localized Skin Lesion;Lyme Arthritis;Lyme Disease;Mediator;Molecular Genetics;Mus;Muscle;Muscle Development;muscle form;Musculoskeletal;Myeloid Cells;Neuropathy;new therapeutic target;novel;Order Spirochaetales;Pain;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;positional cloning;prevent;Production;Proteins;Quantitative Trait Loci;Radiation Chimera;Reading Frames;Recombinants;Regulation;Regulatory Pathway;Reporting;Research;RNA Interference;Role;Sampling;Severities;Skeletal Muscle;skin lesion;small molecule inhibitor;Source;Symptoms;Synovial Fluid;therapeutic target;tick bite;tick borne spirochete;Tissues;TP53 gene;Up-Regulation

PROJECT_TITLE: Molecular Genetics of Lyme Arthritis

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Genetics;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE: Biliary atresia (BA) is a cholestatic liver disease of infancy that is the leading cause of pediatric liver transplantation. Evidence suggests a role for macrophages in the pathogenesis of BA, however, the specific subpopulations that promote inflammation and ongoing liver injury have not been determined. We aim to define the distinct role of macrophage subsets in the disease mechanism of BA and ultimately identify novel cell subset- specific treatment strategies to improve disease outcome for children with BA.

PI_NAMEs: TAYLOR, SARAH ANN (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: adaptive immunity;Advisory Committees;Alagille Syndrome;antagonist;Award;Basic Science;big-data science;bile duct;Biliary;Biliary Atresia;Bioinformatics;Biology;career;career development;CCL4 gene;CD3D gene;CD7 gene;CD8-Positive T-Lymphocytes;Cell Surface Proteins;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Child;Childhood;Cholestasis;Cirrhosis;Clinical Data;Collaborations;Collection;comparison control;Computer Analysis;Data;Diagnosis;Dichloromethylene Diphosphonate;differential expression;Disease;Disease Outcome;Disease Progression;Educational process of instructing;Ensure;Etiology;Foundations;Funding;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;Hepatic;Heterogeneity;Human;IL7R gene;Immune;Immune response;Immune Tolerance;Immunologic Stimulation;Immunologist;Immunology;immunoregulation;improved;Individual;infancy;Inflammation;Inflammatory;Inflammatory Infiltrate;Injury;innovation;interest;Intraperitoneal Injections;Kupffer Cells;Laboratories;Ligation;lipid metabolism;Lipids;Liposomes;liver injury;liver transplantation;Lymphocyte Activation;Macrophage;Maintenance;Manuscripts;Mentors;monocyte;mouse model;Mus;Nature;Neonatal;new therapeutic target;Newborn Infant;novel;Obstruction;Pathogenesis;Pathogenicity;Patients;Pediatrics;Physicians;Population;Productivity;professor;protein expression;PTPRC gene;RANTES;recruit;Regulation;Regulator Genes;Research;Research Personnel;Rhesus;Rheumatology;Role;Rotavirus;S100A8 gene;S100A9 gene;Saline;Scientist;Severity of illness;single-cell RNA sequencing;skills;Sorting;success;T-Lymphocyte;Techniques;Time;Training;transcriptome sequencing;Translational Research;translational study;Transplantation;treatment strategy;Universities;validation studies;Work

PROJECT_TITLE: Macrophage Regulation of Immune Pathogenesis of Biliary Atresia

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Transport of nucleoside chemotherapeutic drugs is primarily accomplished in mammalian cells through Equilibrative Nucleoside Transporter 1 (ENT1), considered constitutively on, redistributing drugs across a bilayer via facilitated diffusion. Preliminary evidence, however, indicates that ENT1 transport of the chemotherapeutic gemcitabine in endothelial cells requires gemcitabine-induced acid sphingomyelinase (ASMase) activation, formation of ceramide-rich platforms (CRPs) on the external plasma membrane, and ENT1 insertion into CRPs for optimized transport function. We propose the existence of a previously- unrecognized form of chemoresistance involving suppression of ENT1 function, reversible by pharmacologic activation of ASMase/Ceramide Signaling.

PI_NAMEs: KOLESNICK, RICHARD N (contact)

PROJECT_TERMS: acid sphingomyelinase;analog;Angiogenesis Inhibitors;antagonist;anti-cancer;Apoptosis;Apoptotic;Award;bevacizumab;Biology;cancer therapy;Cell Death;cell injury;Cell membrane;Cells;Ceramides;Chemoresistance;Chemosensitization;chemotherapy;Clinical Trials;Cytidine;Data;DC101 Monoclonal Antibody;derepression;design;Diffusion;Dose;Endothelial Cells;Endothelium;Engineering;Equilibrative Nucleoside Transporter 1;Etoposide;Extracellular Space;Failure;follow-up;gemcitabine;Gene Delivery;gene therapy;Grant;Histology;Hydrolase;Hydrolysis;Implant;improved;in vivo;inhibitor;Investigation;KDR gene;Lysosomes;Mammalian Cell;Manufacturer;Mediating;Membrane;Memorial Sloan-Kettering Cancer Center;Mus;nanoliposome;neoplastic cell;Nucleoside Transporter;Nucleosides;Outcome;Paclitaxel;Pharmaceutical Preparations;pharmacologic;phase II trial;preclinical study;prevent;programs;Proliferating;Proteins;Radiation;Radiation therapy;Reagent;Resistance;response;Rights;Role;Sarcoma;Schedule;Services;Signal Transduction;Site;Soft tissue sarcoma;Sphingolipids;Sphingomyelins;symposium;synergism;technology development;Testing;Therapeutic;treatment response;tumor;Tyrosine Kinase Inhibitor;uptake;Validation;Vascular Endothelial Growth Factors;Vegf inhibition;Xenograft procedure

PROJECT_TITLE: Ceramide-Rich Platforms Functionalize Gemcitabine Uptake

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Asthma;Climate-Related Exposures and Conditions;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

PHR: Project Narrative If successful, this project will define new mechanisms linking maternal exposure to diesel exhaust with predisposition to asthma in offspring, reveal putative therapeutic targets to prevent asthma and identify novel early biomarkers of asthma risk.

PI_NAMEs: GORSKA, MAGDALENA MARIA (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Address;Adoptive Transfer;airway epithelium;Allergic Disease;Area;Asthma;Biological Markers;Birth Weight;Blood specimen;Body Weight decreased;CD34 gene;Cell Differentiation process;cell growth;Cells;Cessation of life;Childhood Asthma;cigarette smoke;Coculture Techniques;cytokine;Cytoplasmic Granules;Data;design;Development;Diesel Exhaust;early childhood;early detection biomarkers;Eating;Endowment;Enhancers;Environmental Exposure;Enzyme-Linked Immunosorbent Assay;epidemiology study;Epithelial Cells;Epithelium;Exposure to;fetal;Fetal Growth Retardation;Fetal Tissues;Fetus;Flow Cytometry;functional outcomes;Future;Goals;Granzyme;Growth;Growth Inhibitors;Health;hematopoietic tissue;high risk;Human;Immune response;Immunity;Impairment;in utero;In Vitro;indexing;Injections;instrument;Interleukin-13;Lead;Life;Link;Lymphocyte;Lymphoid Cell;Maternal Exposure;Measures;Mediating;Mediator;meetings;Metabolic;Metabolism;Microscopy;Modeling;Molecular;Mothers;mouse model;Mus;Natural Immunity;Natural Killer Cells;novel;Null Lymphocytes;offspring;particle;Pathway interactions;Peptide Hydrolases;Placenta;Pollution;Predisposition;prenatal;Preschool Child;prevent;Process;Production;progenitor;programs;Proteins;pup;receptor;reconstitution;repaired;response;Risk;Role;Serum;Side;Sorting;Starvation;STAT6 gene;synergism;Testing;Th2 Cells;therapeutic target;Time;tissue repair;Tissues;Toxic Environmental Substances;trait;transcription factor;transcriptome sequencing;transmission process

PROJECT_TITLE: Asthma susceptibility due to environmental programming of innate immunity in utero

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because insights into the specific molecular mechanisms by which androgens control prostate cancer (CaP) progression are ultimately expected to provide the foundation to develop novel treatment options that are tailored to the specific AR-dependent events that underlie the lethal phenotype of CaP, a malignancy that causes more than 30,000 deaths annually in the US. Thus, the proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that will help reduce the burdens of human cancer.

PI_NAMEs: HEEMERS, HANNELORE  (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: Affect;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgen Response Element;androgen sensitive;Androgens;ATAC-seq;Benign;Binding;Biological Assay;Biotin;Bypass;cancer survival;Cell Physiology;Cell Survival;Cessation of life;ChIP-seq;Chromatin;Clinical;clinical application;clinically relevant;Complex;deprivation;Development;Disease Progression;DNA Binding;Environment;Event;Foundations;Funding;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Growth;Human;Impairment;improved;inhibitor;innovation;insight;knock-down;Knowledge;Laboratories;Left;Ligands;Ligation;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metastatic Prostate Cancer;Mission;Modality;Modeling;Molecular;Monomeric GTP-Binding Proteins;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Nucleic Acid Regulatory Sequences;Oncogenes;Outcome;Output;overexpression;patient derived xenograft model;Patients;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;prevent;Prostate;prostate cancer cell;prostate cancer model;prostate cancer prevention;prostate cancer progression;Prostate Cancer therapy;Protein Analysis;Protein Kinase;Proteome;Public Health;receptor binding;Receptor Signaling;recruit;Regulation;Remission Induction;Research;Resistance;response;response biomarker;RNA;Role;Sampling;Serum Response Factor;Signal Pathway;Signal Transduction;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Tissues;transcription factor;transcriptome;transcriptome sequencing;treatment strategy;United States National Institutes of Health;Work;Xenograft procedure

PROJECT_TITLE: Toward Selective Androgen Deprivation by Targeting Androgen Activation of SRF

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Disability Research;Lung;Neurosciences;Pediatric;Prevention;Rare Diseases;Sleep Research;Spina Bifida

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PUBLIC HEALTH RELEVANCE STATEMENT / PROJECT NARRATIVE Myelomeningocele is a permanently disabling birth defect; while state-of-the-art treatment can improve motor outcomes, cognitive disabilities are expected for most affected individuals. This project aims to assess sleep- disordered breathing as a potentially remediable contributor to the abnormal cognitive outcomes for children with myelomeningocele. The study goals are directly relevant to the NIH mission, which calls for the prevention and treatment of disease to enhance health and reduce disability, and to enable all individuals to achieve their full potential and live more fulfilling lives.

PI_NAMEs: BARKS, JOHN D (contact);CHERVIN, RONALD D;SHELLHAAS, RENEE A.

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: 2 year old;Affect;Age;American;Apnea;Brain Stem;Caffeine;Child;Childhood;Clinical;clinical practice;Clinical Trials Design;clinically relevant;Cognitive;Cognitive deficits;cognitive disability;cohort;Congenital Abnormality;Consent;Creation of ventriculo-peritoneal shunt;Data;Defect;Development;disability;Disabling;Disease;Electroencephalography;Enrollment;Evaluation;Executive Dysfunction;fetal;fetus surgery;follow-up;Foundations;Functional disorder;Funding;Future;Gestational Age;Goals;Health;high risk;hindbrain;Hydrocephalus;improved;indexing;Individual;infancy;Infant;Infant Development;Infrastructure;innovation;Intensive Care;Intervention;Intervention Studies;Longitudinal Studies;Lung;malformation;Measures;Medical;Medicine;Meningomyelocele;mental development;Michigan;Mission;Mothers;Motor;multidisciplinary;Musculoskeletal;Neonatal;Neonatal Screening;neonate;neurobehavioral;Newborn Infant;non rapid eye movement;Observational Study;Operative Surgical Procedures;Outcome;Oxygen;Parents;Patients;Polysomnography;Population;positive airway pressure;postnatal;prenatal therapy;Prevention;Procedures;programs;public health relevance;Quality of life;Questionnaires;recruit;repaired;Reporting;Research Design;Research Personnel;Risk;Risk Factors;routine screening;screening;Seizures;sex;Sleep;sleep abnormalities;Sleep Apnea Syndromes;sleep behavior;sleep pattern;sleep physiology;Snoring;Socioeconomic Status;Specialized Center;Spinal;Spinal Cord;Spinal Dysraphism;standard of care;Stratification;Sudden Death;Symptoms;Translating;treatment strategy;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Sleep-disordered breathing in infants with myelomeningocele

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

PHR: PROJECT NARRATIVE  Only recently has nationwide voluntary public reporting for congenital heart surgery been implemented. The impact of this initiative on outcomes and assessment of caregiver preferences regarding public reporting have not been studied. Given the importance of this data for parents, policy makers, and healthcare providers, an improved understanding of the impact of public reporting on outcomes of patients with congenital heart disease in need of cardiac surgery is needed.

PI_NAMEs: JAYARAM, NATALIE  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Adult;Advocate;Area;Behavior;Cardiac Surgery procedures;Cardiology;Cardiovascular Diseases;Cardiovascular system;care outcomes;career;career development;Caregivers;Caring;Case Mixes;Characteristics;Child;Child Care;Child health care;Childhood;Cities;Clinical;clinical care;Complex;Comprehension;congenital heart abnormality;Congenital Heart Surgery;Coupled;Data;Data Analyses;data format;Data Reporting;Databases;design;Development Plans;Diagnosis;Disclosure;Education;education planning;effectiveness evaluation;experience;Face;Faculty;Family;Focus Groups;Goals;Health;Health Personnel;Health Services;Healthcare;Heterogeneity;high risk;Hospitals;improved;improved outcome;Inpatients;Institution;Investigation;Kansas;Learning Skill;Life;Light;meetings;member;Mentorship;Methodology;Methods;Missouri;mortality;Nature;operation;Operative Surgical Procedures;Outcome;Outcomes Research;Parents;patient engagement;Patient Preferences;Patient Selection;Patient-Focused Outcomes;Patients;Pattern;pediatric cardiologist;pediatric department;pediatric patients;Pediatrics;Policies;Policy Maker;preference;pressure;Process;professor;profiles in patients;programs;Provider;Qualitative Research;Quality of Care;Reporting;Research;Research Personnel;Risk;Risk Adjustment;Sample Size;Science;Severities;Site;skill acquisition;social;surgery outcome;Time;Training;Travel;Universities;Work

PROJECT_TITLE: The Impact of Public Reporting on Procedural Outcomes Following Congenital Heart Surgery

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Asthma;Genetics;Lung;Pediatric

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: NARRATIVE  It remains difficult to effectively alleviate asthmatic symptoms and limit disease progression in children with severe asthma. While corticosteroids can be effective, children with severe asthma develop corticosteroid insensitivity or resistance making their disease difficult to manage. The goal of this proposal is to understand how inflammation promotes corticosteroid resistance in the context of severe pediatric asthma. These studies are also aimed to assess the potential for therapeutic strategies to improve corticosteroid sensitivity.

PI_NAMEs: BRITT, RODNEY  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Adrenal Cortex Hormones;Adult;airway hyperresponsiveness;airway inflammation;airway obstruction;airway remodeling;Allergens;allergic airway inflammation;Asthma;asthmatic;ATAC-seq;Bioinformatics;Biological;Cells;Child;Childhood;Childhood Asthma;Chromatin;Chromatin Structure;Chronic;Clinical;Complex;cytokine;Data;Deposition;Development;Disease;Disease Progression;DNA;Dose;Exhibits;Exposure to;Extracellular Matrix;Functional disorder;Genes;Genetic Transcription;Glucocorticoid Receptor;Goals;Health;healthcare burden;Histology;Human;human model;Hypertrophy;Image;Immune;immune cell infiltrate;Immune Cell Suppression;improved;Infiltration;Inflammation;Inflammatory;Inhalation;inhibitor;Interferon Type II;Knockout Mice;Lung;Lymphocyte;Lymphocytic Infiltrate;Mediating;Molecular;Morbidity - disease rate;mouse model;Mus;Muscle function;muscular structure;MYH11 gene;novel;novel therapeutic intervention;Nuclear Translocation;p65;Pathway interactions;Phosphorylation;Post-Translational Regulation;Production;Proliferating;receptor;Regulatory Pathway;Reporting;Resistance;resistance gene;respiratory examination;respiratory smooth muscle;Role;Side;Signal Pathway;Smooth Muscle;Steroid Resistance;Steroid therapy;Steroids;Symptoms;synergism;Testing;Therapeutic;TNF gene;Transcriptional Regulation;transcriptome sequencing

PROJECT_TITLE: Airway Structural Cells and Corticosteroid Resistance in Asthma


NIH_SPENDING_CATS: Cancer;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative In this application, we hypothesize that the mammalian body possesses special small spaces within tissues, where stem cells are shielded from immune attack. This sanctuary for stem cells may protect transplanted stem cells from immune attack, and further shield cancer cells from immune attack and tumor immunotherapy, resulting in the relapse following the cancer treatment. We will validate this hypothesis to uncover new disease mechanisms, and further develop novel therapeutic strategies to manipulate the oasis for stem cells to improve the outcome of stem cell transplantation and cancer.

PI_NAMEs: FUJISAKI, JOJI  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Allogenic;arteriole;Blood capillaries;Blood Vessels;Bone Marrow;Bone Surface;cancer cell;cancer stem cell;cancer therapy;Cells;Cellular biology;Cellular Stress;Discontinuous Capillary;Disease;Elements;embryonic stem cell;Engraftment;Exhibits;Fingerprint;FOXP3 gene;Genes;germline stem cells;hematopoietic stem cell niche;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Heterogeneity;Image;Immune;Immunocompetent;Immunologics;improved;improved outcome;insight;leukemia;leukemic stem cell;Link;Location;Malignant - descriptor;Malignant Neoplasms;Molecular Profiling;Mus;neoplasm immunotherapy;Nitric Oxide;novel;novel therapeutic intervention;novel therapeutics;pharmacologic;Placenta;Population;Predisposition;Property;reconstitution;Regulation;Regulatory T-Lymphocyte;Relapse;Resistance;RNA;Role;self-renewal;Signal Transduction;Site;stem cell biomarkers;stem cell engraftment;stem cell function;stem cell niche;Stem cell transplant;stem cells;stemness;Stress;T-cell receptor repertoire;Testing;Testis;therapy development;therapy resistant;Tissues;transcriptome sequencing;Transplantation

PROJECT_TITLE: Privileged and primitive hematopoietic stem cells, niches, and regulatory T cells

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Rheumatoid Arthritis

PHR: Complement activation is believed to play a major role in the development of rheumatoid arthritis (RA) in humans. Studies in animal models identify specific processes that appear to allow complement to be activated and result in tissue destruction. However, important gaps remain in our knowledge of the roles of complement in patients with RA. A better understanding of the role of complement and the underlying causes of dysregulation of this pathway in patients will not only provide important translational science insights but also help to identify new targets and therapeutic approaches.

PI_NAMEs: HOLERS, VERNON MICHAEL (contact)

PROJECT_TERMS: Acceleration;activation product;Address;Adopted;Affect;Animal Model;Anti-citrullinated peptide antibody;Antigens;Appearance;Arthritis;Attention;Autoantibodies;Autoantigens;autoimmune arthritis;Autoimmune Diseases;autoimmune pathogenesis;Biological Markers;Biopsy;Blood;Blood specimen;bone erosion;cell type;Chromosome Mapping;citrullinated protein;Clinical;Clinical Trials;Combined Modality Therapy;Complement;Complement Activation;Complement Factor H;complement system;cytokine;Cytokine Activation;Development;Diagnosis;disability;Disease;disease model;Disease remission;Fibroblasts;ficolin-beta;Funding;gene complementation;Gene Expression;Generations;Goals;Grant;Human;human disease;human model;Immune;immunoregulation;improved;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Arthritis;information model;Injury;insight;Joints;Knowledge;Lectin;Lung;Mannose Binding Lectin;Medicine;mouse model;mucosal site;Mucositis;Mus;natural antibodies;Natural History;Natural Immunity;neoantigens;next generation;novel;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;patient subsets;Patients;Pattern;Phase;Phenotype;Play;Population;Positioning Attribute;pre-clinical;Process;Production;prognostic;programs;Proteins;Reaction;Regulation;Reporting;Rheumatoid Arthritis;Role;Sampling;Serine Protease;single cell technology;skills;societal costs;Synovial Cell;Synovial Membrane;Synovitis;System;Systemic Lupus Erythematosus;targeted treatment;Therapeutic;tissue injury;Tissues;Translating;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: Complement in the Pathogenesis of Autoimmune Arthritis

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PHR: PROJECT NARRATIVE Sarbecoviruses have crossed from bats to humans twice in the last two decades via viruses that emerged from distinct locations on the sarbecovirus evolutionary tree. Investigating sarbecoviruses from points on the evolutionary tree that have not already crossed the species barrier can yield important insight into differences in structure and antigenicity will allow for the development of tools to respond rapidly to future spillover of sarbecoviruses. I propose to investigate the structure, receptor usage and antigenicity of clade 3 sarbecoviruses to prepare a foundation upon which timely responses to spillover can be built.

PI_NAMEs: ZEPEDA, SAMANTHA KATHLEEN (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: 2019-nCoV;ACE2;Africa;African;Amino Acids;Animals;Antibodies;Antibody Therapy;Asia;Binding;Biological Assay;biophysical analysis;Cell membrane;Cells;Chiroptera;Clinical;clinical development;Clinical Treatment;Coronavirus;Coronavirus spike protein;COVID-19 outbreak;Cryoelectron Microscopy;Development;Disease;Domestic Animals;Effectiveness;emerging virus;Europe;European;Foundations;Future;Genetic Drift;Genetic Recombination;Geographic Locations;Glycoproteins;Head Start Program;Human;Human Cell Line;Infection;insight;Interferometry;Kenya;Knowledge;Location;member;Membrane Glycoproteins;Monoclonal Antibodies;Mutation;mutation screening;Nature;Neutralization Tests;pandemic preparedness;polyclonal antibody;prevent;Proteins;Publications;Reaction Time;receptor;receptor binding;Receptor Cell;Resistance;response;Russia;Sarbecovirus;sarbecovirus vaccine;SARS coronavirus;SARS-CoV-2 spike protein;Southeastern Asia;Structure;System;Testing;Time;tool;tool development;Transfection;Trees;Tropism;Vaccination;Vaccine Design;vaccine development;vaccine-induced antibodies;Vaccinee;Vaccines;Validation;Variant;Vesicular stomatitis Indiana virus;Viral;Virus;Virus Diseases;Zoonoses;zoonotic coronavirus

PROJECT_TITLE: Understanding spillover potential of European and African bat sarbecoviruses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-F(20)]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: Coordination of presynaptic neurotransmitter release and postsynaptic reception of that signal is fundamental for information processing in the brain, but the local signals that control this form of “synaptic homeostasis” are not well understood. This issue is important as significant links to neurological and neuropsychiatric disorders have now been attributed to defects in the process by which trans-synaptic communication is tuned and maintained in active brain circuits, and thus a deeper understanding of the molecular mechanisms involved may lead to novel treatments for neurological disease. Our work addresses the critical role of the mTOR complex 1 signaling cascade in allowing the postsynaptic neuron to coordinate neurotransmitter release from its presynaptic partners, with the current project focused on the activity-dependent recruitment of the protein degradation machinery to axonal terminals as a fundamental requirement for homeostatic coordination of presynaptic and postsynaptic function. .

PI_NAMEs: SUTTON, MICHAEL MARK ALEXANDER (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Actin-Binding Protein;Address;Area;autism spectrum disorder;Axon;Biology;Brain;Brain-Derived Neurotrophic Factor;Communication;Compensation;Complex;Couples;Coupling;Cyclic AMP-Dependent Protein Kinases;Cytoskeleton;Data;Defect;Dendrites;Development;Disease;Drosophila genus;Electrophysiology (science);Elements;Ensure;Epilepsy;experimental study;Feedback;Forms Controls;FRAP1 gene;Functional disorder;Genetic Models;Health;Hippocampus;Homeostasis;Human;Hyperactivity;Individual;information processing;insight;Intellectual functioning disability;Investigation;Laboratories;Link;Maintenance;Measurement;Mediating;Mediator;Memory;Mendelian disorder;Molecular;mTORopathies;multicatalytic endopeptidase complex;Nature;Nerve Block;Nervous System Disorder;neural;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;neurotransmitter release;novel;optical imaging;Pathway interactions;Peripheral;Phosphorylation;Play;Post-Translational Protein Processing;postsynaptic;postsynaptic neurons;presynaptic;Presynaptic Terminals;Process;Proteasome Binding;protein degradation;Proteomics;Receptor Activation;recruit;Regulation;Role;Signal Pathway;Signal Transduction;Site;Synapses;synaptic function;Synaptic plasticity;Synaptic Vesicles;Testing;Translation Initiation;Translations;ubiquitin-protein ligase;voltage;Work

PROJECT_TITLE: Trans-synaptic control of presynaptic neurotransmitter release


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Human papillomavirus (HPV) infection is responsible for a significant portion of oropharyngeal squamous cell carcinoma and the HPV E7 protein facilitates degradation of host tumor suppressor PTPN14, promoting activation and nuclear translocation of YAP1 oncoprotein in general keratinocyte models of head and neck squamous cell carcinoma. This activity of E7 leading to YAP1 activation by PTPN14 degradation has not been studied in oropharyngeal models of carcinoma and the overall pathway for PTPN14-dependent YAP1 regulation remains largely unknown. In this proposal I will determine if PTPN14 degradation by E7 is activating YAP1 in HPV-positive OPSCC cells and establish details of the mechanism for YAP1 phosphorylation and inhibition by PTPN14.

PI_NAMEs: BLAKELY, WILLIAM JAMES (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: 3-Dimensional;Automobile Driving;Basal Cell;Binding;Biotin;Biotinylation;cancer cell;carcinogenesis;Carcinoma;Cell Differentiation Induction;Cell Differentiation process;cell growth;Cell Line;Cell model;Cell Nucleus;cell transformation;Cycloheximide;Cytoplasm;Data;Differentiated Gene;DNA biosynthesis;Epithelium;Exclusion;experimental study;extend lifespan;Gene Expression;gene repression;Goals;Growth;Head and Neck Squamous Cell Carcinoma;high risk;HPV E7;HPV negative;HPV positive;HPV-High Risk;Human;Human papilloma virus infection;human papilloma virus oropharyngeal squamous cell carcinoma;Human Papillomavirus;Immunofluorescence Microscopy;Immunoprecipitation;keratinocyte;knock-down;Knock-out;knockout gene;Knowledge;Label;LATS1 gene;life span;Malignant Epithelial Cell;malignant mouth neoplasm;Malignant Neoplasms;malignant oropharynx neoplasm;Measures;Mediating;Modeling;mutant;Mutate;Nuclear;Nuclear Translocation;Oncogenic;Oncoproteins;Oral;Organoids;Oropharyngeal;Oropharyngeal Squamous Cell Carcinoma;overexpression;Pathway interactions;penis foreskin;Phosphorylation;Phosphotransferases;prevent;Protein Binding Domain;Protein Dephosphorylation;Proteins;RB1 gene;Regulation;Repression;retinoblastoma tumor suppressor;Serine;Signal Pathway;Signal Transduction;Somatic Mutation;spheroids;Stratified Squamous Epithelium;Streptavidin;Testing;Transcript;Transcription Coactivator;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;two-dimensional;Viral;Virus;Virus Replication;Western Blotting

PROJECT_TITLE: Determining the mechanism for YAP1 activation by HPV E7 in oropharyngeal carcinoma

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Otitis Media;Patient Safety;Pediatric;Primary Health Care

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE An ear infection (otitis media) is the most common reason for a child to see a doctor in the United States and is, therefore, an extremely important public health problem. Making matters worse, doctors have a great deal of difficulty making an accurate diagnosis of an ear infection because it is hard to look at a child’s ear and even when the doctor gets a good look, they can only see the ear drum and not the place behind the ear drum where the infection is happening. This research plan will use a new technology (optical coherence tomography), which is a like an ultrasound for the ear, to see if this technology can make it easier for doctors to make the right diagnosis in children with ear infections and reduce the number of antibiotics and surgeries that are needed for ear infections.

PI_NAMEs: BOPPART, STEPHEN A;KERSCHNER, JOSEPH E (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: accurate diagnosis;Acute;Affect;Ambulatory Care Facilities;Antibiotics;antimicrobial;Audiology;automated algorithm;Child;Childhood;childhood hearing loss;Chronic;Clinic;clinical decision-making;comparative;cost;Data;Data Set;Decision Making;Developmental Delay Disorders;Diagnosis;diagnostic accuracy;diagnostic algorithm;diagnostic tool;Disease;Ear;ear infection;Earache;Education;effusion;Health Expenditures;Image;image processing;improved;Infection;Informed Consent;Life;machine learning algorithm;Medical;Microbial Biofilms;middle ear;Morbidity - disease rate;new technology;Operative Surgical Procedures;Optical Coherence Tomography;Otitis Media;Otitis Media with Effusion;Otolaryngologist;Otolaryngology;Otoscopy;Pathology;Patient observation;Patients;pediatric patients;pediatrician;Prevalence;Prevention;Primary Care;primary care clinic;Public Health;Recording of previous events;Research;Resolution;Resources;Speech;Technology;Time;Tympanic membrane;Tympanometry;ultrasound;United States

PROJECT_TITLE: Otitis Media Diagnosis and Treatment


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE While cold exposure blocks peripheral sensory signaling in most mammals, the hibernating thirteen-lined ground squirrel preserves touch sensation (mechanosensation) at a body temperature of 2-4°C. This proposal utilizes physiological and molecular methods to identify the modifications at dorsal root ganglion ion channels underlying cold-resistant mechanosensation. Understanding cellular mechanisms of extreme thermal tolerance in the mammalian nervous system will provide new targets for the mitigation of neuronal damage following organ supercooling or perioperative hypothermia.

PI_NAMEs: GREENBERG, REBECCA  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Action Potentials;Body Temperature;cell type;Cells;Characteristics;Clinical;cold temperature;cost;Cues;Data;Drops;Electrophysiology (science);experimental study;Fiber;Goals;Homeostasis;In Situ Hybridization;Individual;Ion Channel;Ion Channel Gating;Ions;K ATPase;Kinetics;Laboratories;Light;Mammals;Mechanics;Mechanoreceptors;mechanotransduction;Membrane Potentials;Methods;Modality;Modification;Molecular;Molecular Profiling;Mus;natural hypothermia;Nerve;Nervous System;neurobiological mechanism;Neurons;Neurophysiology - biologic function;Nociception;novel;Organ;patch clamp;Perioperative;Peripheral;Physiological;Piezo 2 ion channel;preservation;pressure;Procedures;Property;Pump;Resistance;response;Rest;Role;Seasons;Sensory;Signal Transduction;Skin;Spermophilus;Spinal Ganglia;Squirrel;Stimulus;Tactile;Temperature;Touch sensation;transcriptome sequencing;Universities;voltage;Voltage-Gated Potassium Channel;Whole-Cell Recordings;Work

PROJECT_TITLE: Cellular and molecular mechanisms of cold-adapted mechanosensation in the hibernating squirrel


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Complementary and Integrative Health;Digestive Diseases;Nutrition;Physical Activity;Prevention;Rehabilitation;Social Determinants of Health;Telehealth

PHR: Colorectal cancer is the 2nd leading cause of cancer death in the United States. A lifestyle consistent with the American Cancer Society (ACS) Nutrition and Physical Activity Guidelines is associated with approximately 40% lower risk of death in people with colorectal cancer, but few colorectal cancer survivors follow the guidelines. This study will use an innovative framework to identify an intervention to improve physical activity, diet, and body size among colorectal cancer survivors that can be remotely delivered and broadly accessible.

PI_NAMEs: VAN BLARIGAN, ERIN LYNN (contact)

PROGRAM_OFFICER_NAME: AGURS-COLLINS, TANYA

PROJECT_TERMS: Accelerometer;Address;Affect;Age;American Cancer Society;Behavior;behavior change;Behavior Therapy;Behavioral;Biological;Biology;Body mass index;Body Size;California;Cancer Etiology;cancer recurrence;cancer survival;Cancer Survivor;Cessation of life;Clinical;colon cancer patients;Colon Carcinoma;Colorectal Cancer;colorectal cancer risk;Counseling;Dana-Farber Cancer Institute;Data;design;Diagnosis;Diet;Dietary Fiber;digital health;Disinhibition;effective intervention;Effectiveness;end of life;Engineering;Enrollment;Ethnic Origin;expectation;experience;experimental study;Family;Fasting;Friends;Fruit;Gender;Glucose;Goals;good diet;Guidelines;Health;improved;Individual;inflammatory marker;innovation;Insulin;Interleukin-6;Intervention;Life Style;lifestyle intervention;Literature;Malignant Neoplasms;Measurable;Measures;Mediating;Mediator;men;Mental Depression;Monitor;mortality;mortality risk;multiphase optimization strategy;nutrition;Outcome;Participant;Patients;pedometer;Persons;Physical activity;Physical Function;Population;prevent;primary outcome;Printing;psychologic;Public Health;Race;Randomized;Randomized, Controlled Trials;Recommendation;remote delivery;remote intervention;Reporting;Research;Research Personnel;Resources;San Francisco;Self Efficacy;self reported behavior;social cognitive theory;Social support;sociodemographics;standard care;standardize measure;Subgroup;Survival Rate;Telephone;Testing;Text Messaging;Time;TNF gene;tool;Training;trial enrollment;United States;Universities;Vegetables;wearable device;Woman;women versus men

PROJECT_TITLE: Optimization of a remote intervention to improve nutrition and physical activity in colorectal cancer survivors

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]