ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_CITY: Columbus

ORG_DEPT: PSYCHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative (Public Health Relevance Statement) The proposed project is designed to illuminate how semantic organization emerges in the course of typical development, and how it contributes to the fundamentally human ability to comprehend language. Because language comprehension is critical for reading, and it is often compromised in reading disability (including developmental dyslexia), the proposed project will inform theoretically-based enrichment programs for atypical semantic development, including developing learners who struggle with language comprehension. Specifically, by identifying drivers of semantic development, it will provide theoretical framework for choosing enrichment programs for learners who struggle with vital comprehension skills.

PI_NAMEs: SLOUTSKY, VLADIMIR M (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: 4 year old;9 year old;Address;Adult;Affect;Apple;Child;cognitive development;Comprehension;comprehension skill;Computer Models;Coupled;course development;design;Development;Developmental reading disorder;Eating;Exposure to;Fostering;Fruit;high school;Human;Human Development;improved;Individual;Infant;Knowledge;Language;language comprehension;Language Development;Learning;Link;longitudinal design;Longitudinal Studies;Maps;Measures;novel;Organizational Change;Play;programs;public health relevance;Reading;Reading Disabilities;recruit;Research;Role;Sampling;Semantics;Shapes;Statistical Models;Structure;Testing;tool;Training;Vocabulary;Walking;word learning;Work

PROJECT_TITLE: Semantic Development

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: UNIVERSITY PARK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Non-canonical DNA conformations play dual roles in the cell: they regulate multiple molecular processes, but may also represent hurdles for DNA replication. As a result, non-canonical DNA conformations have been associated with several neurodegenerative diseases, including Amyotrophic Lateral Sclerosis, and are the preferred sites of chromosomal rearrangements in cancer. The studies of non-canonical DNA conformations will advance our understanding of their role in disease etiology and will inform the development of personalized disease treatments.

PI_NAMEs: MAKOVA, KATERYNA  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Affect;Amyotrophic Lateral Sclerosis;Architecture;Base Pairing;Cell Differentiation process;Cells;Characteristics;Chromosomal Rearrangement;Computational Technique;Data;Development;Disease;DNA;DNA biosynthesis;DNA replication fork;DNA Structure;Etiology;Evolution;Future;G-Quartets;genetic evolution;Genetic Variation;Genome;genome annotation;Germ Cells;Goals;Human;Human Genetics;Human Genome;Individual;interest;Laboratories;lens;Life;Malignant Neoplasms;Mammalian Cell;Modeling;Molecular;Molecular Conformation;Molecular Evolution;Mutagenesis;Mutation;Neurodegenerative Disorders;Oxidative Stress;personalized medicine;Play;Pongidae;Population Genetics;Process;replication stress;Role;Shapes;Signal Transduction;Site;Structure;Technology;telomere;Time;Transcription Initiation;Trees;triplex DNA;Variant;Z-Form DNA

PROJECT_TITLE: Non-B DNA and Genome Evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MRAF-C (01)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE This grant will evaluate the association of gender, sex, and their interaction, with cardiovascular disease (CVD) outcomes, leveraging data from three large cohort studies. We will test the impact of gender-related variables and a derived gender score on the metabolome and risk of CVD. These data will advance our understanding of the impact of gender on health and may inform CVD prevention strategies.

PI_NAMEs: BALASUBRAMANIAN, RAJI ;REXRODE, KATHRYN M (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Address;Affect;arm;Behavioral;biobank;Bioinformatics;Biological;biological sex;Biometry;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;Case/Control Studies;Classification;cohort;Cohort Studies;Data;Discrimination;Disease;Disease Outcome;disorder risk;Environmental Risk Factor;Evaluation;expectation;Gender;Gender Identity;Gender Relations;Gender Role;Generations;Genomics;Goals;Grant;Health;Hormones;improved;Individual;Institutionalization;Life Style;Measures;Mediating;men;Metabolic Pathway;metabolome;metabolomics;Nurses' Health Study;Observational Study;Outcome;Participant;Pathway interactions;Prevention strategy;Public Health;Research;Risk Factors;sex;social;social culture;Societies;Strategic Planning;Stroke;Testing;United States National Institutes of Health;Woman;Women's Health

PROJECT_TITLE: Impact of Sex and Gender on the Metabolome and CVD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-P (52)]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: NEW HAVEN

ORG_NAME: ATLASXOMICS INC.

ORG_STATE: CT

PHR: Project Narrative AtlasXomics has developed and is selling an assay to help investigators address the epigenetic dysregulation that underlies many diseases including cancer and neurodegenerative diseases. This research will allow the assay to obtain two levels of gene regulatory information from the same tissue section, conserving precious biological samples and helping investigators better understand the cellular and molecular circuitry underlying the biological function of complex tissues and organs.

PI_NAMEs: DENG, YANXIANG ;SABINA, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Address;Alzheimer's Disease;ATAC-seq;Bar Codes;Biochemistry;Bioinformatics;Biological;Biological Assay;Biological Process;biological systems;Biology;brain tissue;Budgets;Cancer Center;cancer therapy;Cell Nucleus;Cell Physiology;cell type;Cells;Chromatin;commercial launch;commercialization;Complex;Computer Analysis;Computer software;Consumption;Data;data access;Data Analyses;Data Files;data integration;data portal;data quality;Data Set;Democracy;design;Disease;Dissociation;Dust;Elements;Epigenetic Process;epigenome;epigenomic profiling;epigenomics;expectation;experimental study;Exposure to;Feedback;Fluorescent in Situ Hybridization;Freezing;Gene Expression Regulation;gene regulatory network;Genes;Genome;Genomics;Heterogeneity;image registration;insight;interactive visualization;large datasets;Licensing;Link;Malignant Neoplasms;Maps;Market Research;Marketing;Messenger RNA;metabolome;Methods;Microfluidic Microchips;Microfluidics;Modality;Molecular;Molecular Profiling;Motivation;multimodality;Multiomic Data;multiple omics;Mus;Neurodegenerative Disorders;novel;open source;Organ;Outcome;Pathology;Patients;Phase;Phenotype;Process;Proteome;Proteomics;Publications;Publishing;Reaction Time;Reproducibility;Research;Research Personnel;Research Project Grants;Resolution;Running;Sampling;satisfaction;Scheme;sequencing platform;Services;single cell genomics;single molecule;Small Business Technology Transfer Research;Software Tools;Structure;Surveys;Suspensions;Technology;Time;Tissue Sample;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;translational scientist;Universities;usability;Visualization;Visualization software;web site

PROJECT_TITLE: Co-profiling (whole  transcriptome  and  epigenome)  of  intact  tissue  to  understand  gene  regulatory networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (15)]


NIH_SPENDING_CATS: Bioengineering;Patient Safety;Physical Activity;Urologic Diseases;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: LIV LABS INC.

ORG_STATE: IL

PHR: Project Narrative Some 29 million American women have a current, unmet need for conservative, non-surgical treatment for stress urinary incontinence (SUI); and that number will rise to 35 million by 2060 as the population ages. The proposed SBIR Phase IIB project will evaluate the safety, efficacy and tolerance of a novel, soft spring continence pessary that provides the utility of a reusable, fitted pessary with unprecedented ease of use, physical comfort, and psychological security. The goal is to build widespread adoption of a patient-controlled treatment that improves quality of life and reduces other chronic illness risks while simultaneously reducing demand for expensive clinical care.

PI_NAMEs: ROBERTS, MELODY ANN (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Admission activity;Adoption;Adverse event;Affect;Age;aging in place;American;Anatomy;Anterior;arm;Atrophic;biomaterial compatibility;Bladder;career;Caring;Chronic Disease;Client satisfaction;Clinical;clinical care;Clinical Protocols;Clinical Research;Clinical Trials;Collection;commercialization;Computer software;consumer product;Consumption;cost;Cream;Data;design;Devices;Diagnosis;Effectiveness of Interventions;effectiveness study;efficacy study;Engineering;Enrollment;Ensure;Estrogens;Excision;Exercise;Exertion;experience;Extravasation;fabrication;Feasibility Studies;Feedback;Fingers;fitness;flexibility;follow-up;Frequencies;Goals;Growth;Health;Home;Hour;Human;improved;Incontinence;incontinence symptom;Injury;Institutional Review Boards;Intervention;invention;irritation;Laceration;Left;Legal patent;Length;Life;Lubricants;Manuals;manufacture;Marketing;Measures;mechanical energy;Medical;Medical Device;medical schools;Membrane;microbiota;Minor;Modeling;Mucous Membrane;novel;novel strategies;open label;Operative Surgical Procedures;Outcome;Pain;Participant;Patient Education;Patients;Pelvic Floor Muscle;Pelvic floor structure;Pelvis;Pessaries;Phase;Physical Fitness;Population;preference;pressure;Prevalence;programs;prospective;psychologic;Public Health;Quality of life;Questionnaires;Recommendation;Reporting;research clinical testing;resilience;Resources;Risk;Running;Safety;safety assessment;Sampling;satisfaction;secondary endpoint;Security;Self Administration;Self Management;Services;side effect;Silicones;Site;Small Business Innovation Research Grant;Sneezing;Specialist;Standardization;Stress Urinary Incontinence;Surface;Surveys;symptom treatment;System;Technology;Testing;Time;Tissues;Training;Treatment Efficacy;trial planning;Uncertainty;Universities;Urethra;Urine;Vagina;Visit;Walking;Weight;Weight Gain;Well in self;Woman;women's diagnosis;Women's study;women's treatment

PROJECT_TITLE: Phase IIB Clinical and Nonclinical Testing of Soft Spring Continence Pessary for Women, in Support of FDA 510(k) Clearance Requirements

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-R (11)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Congenital Structural Anomalies;Disability Research;Hearing Loss;Neurosciences;Nutrition;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: MISSOULA

ORG_NAME: DERMAXON, LLC

ORG_STATE: MT

PHR: RELEVANCE We propose an innovative new therapeutic strategy to treat Noise-induced hearing loss by using a specific CYP26 inhibitor DX308, to increase retinoic acid concentrations in the inner ear. We detail a plan to determine the minimum safe and effective dose of DX308 improving cochlear morphological and functional outcomes after noise exposure. If successful, this study could provide a novel therapeutic approach for the treatment of Noise-induced hearing loss.

PI_NAMEs: DIAZ, PHILIPPE J (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Ablation;Acids;Acoustic Trauma;Acoustics;Adult;Affect;Age;Agonist;Animals;Antioxidants;Apoptosis;Attenuated;Auditory;Auditory Brainstem Responses;Autopsy;Azoles;Biological Availability;Body Weight decreased;brain stem auditory evoked potentials;Cardiotoxicity;Cell Membrane Permeability;Cell Survival;Cochlea;Collaborations;comparison control;CYP26B1 gene;Cytochrome P450;design;Developed Countries;Dose;Drug Kinetics;economic cost;Embryo Resorption;Embryonic and Fetal Development;Enzyme Inhibitor Drugs;Enzymes;Equilibrium;Exhibits;Family;Feedback;Fetal Resorption;functional outcomes;Future;genotoxicity;Growth;hair cell regeneration;Hair Cells;hearing impairment;hearing loss treatment;Heart;Histologic;Homeostasis;Human;Hypervitaminosis A;improved;in vivo;Inflammation;inhibitor;Injury;Inner Hair Cells;innovation;Intervention;Investigational Drugs;ion channel blocker;Irritants;Labyrinth;Lasers;Liver;malformation;Marketing;Mediating;Medical;Medicine;Membrane Potentials;Metabolic Pathway;Metabolism;Microscopic;Miniature Swine;Modeling;Montana;Morphology;Mus;nanomolar;Noise;noise exposure;Noise-Induced Hearing Loss;novel;novel therapeutic intervention;Oral;Oral Administration;Organ;Organ of Corti;otoacoustic emission;Oxidative Stress;Pathogenesis;Permeability;Persons;Pharmaceutical Preparations;Play;pre-clinical;Pregnancy;Prevention;Protein Isoforms;Recovery;repaired;reproductive toxicity;Research;Resistance;retinoic acid 4-hydroxylase;Retinoic Acid Receptor;Retinoids;ribbon synapse;Rodent;Role;round window;Route;Sensory disabilities;side effect;Signal Transduction;Signaling Molecule;Skin;skin irritation;Synapses;teratogenesis;Teratogens;Testing;Testis;Texas;Therapeutic;Topical application;Toxic effect;Toxicokinetics;Trauma;treatment adherence;Treatment Efficacy;Tretinoin;Tympanic membrane;Universities;Weight;Wistar Rats;Zebrafish

PROJECT_TITLE: Targeting retinoid acid metabolic pathways to treat noise-induced hearing loss

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-M (12)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: CERRITOS

ORG_NAME: HANDL HEALTH LLC

ORG_STATE: CA

PHR: Project Narrative Variation in, and limited access to, healthcare service pricing is a significant contributor to the unsustainable growth of out-of-pocket costs for minority health and disparity populations, leading to avoiding necessary healthcare, significant medical debt and financial stress. Revealing price variation and medical billing discrepancies through consumer-friendly applications with bilingual care navigation assistance can reduce health literacy barriers around the cost of healthcare and improve access and affordability. The purpose of this research is to develop a legislatively compliant, bilingual healthcare services cost estimator and billing management mobile application, powered by a national healthcare pricing database and multidimensional search and quote building technology guided by SMS support.

PI_NAMEs: MARMOUSH, AHMED  (contact)

PROGRAM_OFFICER_NAME: WOLFF, JOSHUA R

PROJECT_TERMS: Access to Information;American;Applications Grants;Appointment;Area;Big Data;bilingualism;Black American;Businesses;Cardiology;care episode;care outcomes;Caring;cluster computing;Code;Collaborations;commercialization;Communication;Communities;cost;cost estimate;Data;data de-identification;data ingestion;data mining;data resource;Databases;Development;Dimensions;Disparity population;economic outcome;Economically Deprived Population;Effectiveness;experience;Faith;Federal Government;federal poverty level;Financial Hardship;Financial Support;Friends;Funding;Gastroenterology;Goals;Growth;Health;health care availability;Health Care Costs;health care service;Health Insurance;Health Insurance Portability and Accountability Act;health literacy;Health Personnel;health plan;Health Policy;Healthcare;Hispanic Americans;hospital services;Hospitals;Improve Access;improved;Individual;Industry;Information Dissemination;Ingestion;Insurance Carriers;Intelligence;Investments;Knowledge;Language;Location;low health literacy;Marketing;Mediation;Medical;medical specialties;member;middleware;minority disparity;Minority Groups;minority health;mobile application;Orthopedics;Patients;Phase;Policies;Positioning Attribute;Price;Provider;Publishing;Research;Research Proposals;Role;Rural;Secure;Services;Small Business Innovation Research Grant;socioeconomic disadvantage;Spanish;Spanish/English;Statutes and Laws;System;Target Populations;Technology;Text Messaging;Time;tool;Translations;Uninsured Medical Expense;United States;United States Centers for Medicare and Medicaid Services;usability;Variant;web app

PROJECT_TITLE: A mobile application to offer upfront healthcare prices and automated medical billing for socioeconomically disadvantaged Americans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-J (10)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative This MIRA proposal will enhance the investigative team’s ability to explore adverse cardiovascular and thermoregulatory consequences of severe burn injuries in human burn survivors. The primary goals of our research are to provide valuable information to the burn survivor (and their caregivers) that is beneficial to improving the quality of life of this under-served and under-researched population, as well as to provide research- verified findings directed at reducing mortality and morbidity risk associated with this devastating and often debilitating injury.

PI_NAMEs: CRANDALL, CRAIG G (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: adverse outcome;Age;Blood flow;Body Surface Area;Burn injury;Cardiac;cardiometabolism;Cardiovascular Physiology;Cardiovascular system;Caregivers;Cerebrovascular Disorders;Coronary Arteriosclerosis;daily functioning;Diabetes Mellitus;Disease;Exhibits;experience;Functional disorder;Goals;healing;Health;Heart Diseases;Heart failure;Heat Waves;Hospitalization;Hospitals;Hour;Human;Hypertension;Impairment;improved;Incidence;Individual;Injury;Kidney;Morbidity - disease rate;mortality;mortality risk;Physical activity;Physiologic Thermoregulation;Population;Quality of life;Research;response;Risk;severe burns;severe injury;Skin;Skin injury;Stress;Stroke;Survivors;Sweating;United States;Work

PROJECT_TITLE: Cardiovascular and thermoregulatory consequences of severe burn injuries

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: JACKSON

ORG_NAME: G V SONNY MONTGOMERY VA MEDCIAL CENTER

ORG_STATE: MS

PHR: The project aims to characterize the cardioprotection of an endogenously produced anti-coagulant protein, activated protein C (APC), against acute reperfusion injury. The study also explores the signaling mechanisms underlying APC’s role in regulating substrate metabolism thereby modulating the heart’s inflammatory response to ischemic insults. The results from these findings could lead to novel therapeutic strategies aimed at limiting cardiac damage for myocardial infarction Veteran patients.

PI_NAMEs: LI, JI  (contact)

PROJECT_TERMS: 5'-AMP-activated protein kinase;activated Protein C;activated protein C receptor;Acute;Address;Affect;age related;Aging;American;AMP-activated protein kinase kinase;Animals;Anti-Inflammatory Agents;Anticoagulants;Apoptosis;Apoptotic;Attenuated;blood glucose regulation;Brain Infarction;Cardiac;cardioprotection;Cardiovascular Diseases;Cause of Death;Cell Survival;Cells;Chronic Obstructive Pulmonary Disease;Clinical;Congestive Heart Failure;Coronary Arteriosclerosis;Coronary Thrombosis;Cytoprotection;Data;Diabetes Mellitus;Diagnostic;Down-Regulation;Enzymes;Extracellular Signal Regulated Kinases;F2R gene;fatty acid metabolism;Financial Hardship;Glucose;glucose metabolism;glucose transport;glucose uptake;Goals;Grant;Health;Heart;heart damage;Heart Injuries;Hemorrhage;Histologic;Homeostasis;Hospitalization;human subject;Hypertension;Immunofluorescence Immunologic;Impairment;In Situ Nick-End Labeling;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Injury;Ischemia;ischemic injury;Ischemic Stroke;JUN gene;Knock-in Mouse;Link;Measures;Mediating;Mental disorders;Metabolic;Metabolism;military veteran;Molecular;monocyte;Morbidity - disease rate;mortality;Mus;myocardial damage;myocardial infarct sizing;Myocardial Infarction;Myocardial Ischemia;N-terminal;neutrophil;novel;novel therapeutic intervention;novel therapeutics;Obesity;Oleates;Oxidation-Reduction;Pathology;Patients;Peptide Hydrolases;Perfusion;Pharmacotherapy;Plasma Proteins;Play;Point Mutation;Population;prevent;Prevention;Production;prognostic;protective effect;Protein C;Protein Kinase;Proteins;Receptor Activation;Recombinants;Regulation;Reperfusion Injury;Reperfusion Therapy;Reporting;response;Risk;Risk Factors;Role;SAPK;Signal Pathway;Signal Transduction;Signaling Protein;Stains;Stress;stress activated protein kinase;Study Subject;System;Testing;TP53 gene;trafficking;Transgenic Mice;Veterans;Western Blotting;Work

PROJECT_TITLE: Activated Protein C in Acute Injury


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Disability Research;Heart Disease;Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Congenital heart disease is the most common structural birth defect, with neurodevelopmental impairment the most important long-term morbidity. This proposal will investigate the relationship between fetal brain development and long-term brain structure and function. The findings will inform clinical care and the development of rational fetal neuroprotective therapies to mitigate neurodevelopmental sequelae in this population.

PI_NAMEs: ROLLINS, CAITLIN  (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: 2 year old;7 year old;Adolescence;Adult;Advanced Development;Affect;Anatomy;Area;Attention;Birth;Brain;brain abnormalities;Brain Hypoxia-Ischemia;brain magnetic resonance imaging;brain volume;Cardiac;Cell Compartmentation;Cells;Cerebral cortex;Cerebrum;Child;Childhood;clinical care;clinical development;clinical risk;cognitive function;cohort;Congenital Abnormality;congenital heart abnormality;critical congenital heart disease;Data;Data Set;Development;disability;Education;Employment;Executive Dysfunction;executive function;experience;fetal;Fetus;Foundations;Genetic;Health;High Prevalence;Impairment;in utero;indexing;individual patient;innovation;Intervention;Knowledge;Live Birth;Location;Magnetic Resonance Imaging;Measures;Medical;Mental Health;Modeling;Morbidity - disease rate;myelination;Nature;neonate;nerve stem cell;Neurobiology;neurodevelopment;Neurodevelopmental Disability;Neurodevelopmental Impairment;neuroimaging;Neurons;neuroprotection;Oligodendroglia;Operative Surgical Procedures;Outcome;Outcome Measure;Pathology;Pathway interactions;Patients;Perinatal;personalized medicine;Placenta;Population;postnatal;Predictive Value;prenatal;primary outcome;Process;processing speed;Proliferating;Property;Quality of life;Recording of previous events;risk stratification;School-Age Population;secondary outcome;Services;Severities;skills;social cognition;Socioeconomic Status;Special Education;Structural Congenital Anomalies;Structural defect;Structure;Surface;Survivors;System;Techniques;Therapeutic;therapy design;Thick;tool;Variant;white matter

PROJECT_TITLE: Fetal Brain MRI as a Predictor of Late Neurodevelopmental Outcome in Congenital Heart Disease

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ORG_CITY: CHICAGO

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

PHR: Type 2 diabetes is a significant condition in VA affecting 20% of VA patients. Adherence to medication regimens and lifestyle factors is important to achieve care goals for these patients. Patients who use active participatory communication behaviors with their providers have better adherence to treatment and better biomedical outcomes, yet many patients are not prepared to engage in active communication with their providers. Existing coaching interventions have not been adopted in practice because of the cost of trained personnel. We have shown the efficacy of a low-cost video that did not require trained personnel. This proposal proposes to test implementation strategies to deliver that video in VA primary care clinics and to test the effectiveness of the video to improve outcomes in a Hybrid Type 2 effectiveness–implementation trial using a cluster randomized stepped wedge design at six sites. This proposal will test feasibility of implementing the video and if successful will generate the evidence to justify widespread dissemination of the video

PI_NAMEs: GORDON, HOWARD S. (contact)

PROJECT_TERMS: Achievement;active control;Address;Adherence;Adopted;Affect;African American;Caring;Chronic;Chronic Disease;Clinic;Clinical;Communication;communication behavior;Communication difficulty;Complex;complex chronic conditions;cost;design;diabetes distress;diet and exercise;Education;effective intervention;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation hybrid;effectiveness/implementation trial;empowerment;ethnic minority;Evaluation;feasibility testing;Focus Groups;follow-up;formative assessment;Funding;Glycosylated hemoglobin A;Goals;group intervention;Guidelines;Health Services;high risk;Human Resources;hybrid type 2 design;Hybrids;implementation evaluation;implementation strategy;improved;improved outcome;innovation;Intervention;Intervention Trial;Life Style;lifestyle factors;low health literacy;Maintenance;Medical;Medical center;Mental Depression;Methodology;model development;Modeling;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Outpatients;patient engagement;patient oriented;patient population;Patient-Centered Care;Patients;Performance;Pharmaceutical Preparations;Phase;Physicians;pragmatic intervention;Preparation;Prevalence;Primary Care;primary care clinic;primary care practice;Process;Promoting Action on Research Implementation in Health Services framework;Provider;provider adoption;provider communication;racial minority;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Regimen;Registered nurse;Reporting;Research;Self Efficacy;Services;shared decision making;Site;success;Symptoms;Testing;Training;Veterans;video delivery;Visit;whole health;Work

PROJECT_TITLE: Empowering Veterans to Actively Communicate and Engage in Shared Decision Making in Medical Visits, A randomized controlled trial

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Pain Research

ORG_CITY: PULLMAN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative Monosodium urate (MSU) induced inflammation affects approximately 4% of Americans and is driven by crystal deposition in the joints which cause intense pain, disability, and tissue destruction. The current therapeutic options have serious drawbacks that warrant investigation into new, more effective treatments. This project investigates pentagalloyl glucose, a molecule that is known to reduce inflammation in other disease states and has the potential to function as a dual inhibitor of two enzymes key to MSU-induced inflammation.

PI_NAMEs: PANIPINTO, PAUL  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Acute;Address;Adverse effects;Affect;Allopurinol;American;Anti-Inflammatory Agents;Antiinflammatory Effect;Antioxidants;Attenuated;Binding;Binding Sites;Bone Resorption;C57BL/6 Mouse;CASP1 gene;Caspase;Categories;chemokine;Chronic Disease;Colchicine;cost;Crystal Formation;cytokine;Data;Deposition;disability;Disease;Docking;Drug Interactions;effective therapy;Enzymes;falls;febuxostat;Flare;Global Change;Glucose;Gout;Human;Hyperuricemia;IL8 gene;Immunology;in silico;In Vitro;in vivo;in vivo evaluation;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;intense pain;Interleukin-1 beta;Intra-Articular Injections;Investigation;Joints;JUN gene;Knowledge;Lipopolysaccharides;Macrophage;MAP3K7 gene;MAPK8 gene;marenostrin;Mediating;Mitogen-Activated Protein Kinases;Modeling;Molecular;molecular dynamics;mouse model;N-terminal;neutrophil;new therapeutic target;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutics;Pain;Pathogenesis;Pathway interactions;Patient Compliance;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;phosphoproteomics;Phosphorylation;Phosphorylation Inhibition;Phosphotransferases;Post-Translational Protein Processing;Probenecid;Process;Production;Publishing;receptor;Regulation;Research Personnel;Rheumatism;Signal Transduction;simulation;Structure-Activity Relationship;Students;Testing;Therapeutic;Therapeutic Agents;Tissues;TNF gene;Training;training opportunity;Transforming Growth Factor beta;Up-Regulation;uptake;Urate;Uric Acid;Work;Xanthine Oxidase

PROJECT_TITLE: Pentagalloyl glucose as an inhibitor of monosodium urate induced inflammation


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

ORG_CITY: RICHMOND

ORG_DEPT: DENTISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT  Periodontal diseases are a major burden for our society: half of Americans over the age of 30 have periodontitis; the severe form of periodontitis is the 6th most prevalent health condition worldwide, affecting 11% of the population; about 30% of people aged 65–74 have no natural teeth, and severe periodontitis is the leading cause for tooth loss. Effective, safe and economical therapies to control the host immune response are an unmet need for current periodontal disease treatment and results from the proposed study will provide foundational knowledge for the development of host-modulation therapy based on a potent epigenetic modifier, which has the potential to impact millions of Americans affected by periodontal diseases. 1

PI_NAMEs: LIN, ZHAO  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acetylation;Affect;Age;aged;Alveolar Bone Loss;American;Animal Model;Antibiotic Therapy;Binding;Bone Resorption;BRD2 gene;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Cardiovascular Diseases;Cells;Chromatin;chromatin modification;clinical application;Clinical Data;Complex;cytokine;Data;Debridement;Development;diagnostic biomarker;Disease;Disease Progression;disorder control;driving force;Drug Controls;dysbiosis;Ecosystem;Environmental Exposure;epigenetic drug;Epigenetic Process;epigenetic regulation;Epithelial Cells;experimental study;gain of function;Gene Expression;Gene Expression Regulation;gene network;Genes;genetic manipulation;Genetic Transcription;genome-wide;genomic locus;Gingiva;Harvest;Health;Histone Acetylation;histone modification;Histones;Human;Immune;Immune response;in vivo;Inflammation;Inflammatory;Injections;Innovative Therapy;Knowledge;Ligation;Ligature;loss of function;Lysine;Mechanics;Mediating;microbial;Microbial Biofilms;microbial community;microbiome;microbiota;Modeling;Modification;Molecular;Mus;novel;novel therapeutics;Oral Administration;oral cavity epithelium;Osteitis;Osteoclasts;Osteogenesis;pathogen;Pathogenesis;Patients;Pattern;Periodontal Diseases;Periodontitis;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phase III Clinical Trials;Play;Population;Porphyromonas gingivalis;Predisposition;prevent;Production;programs;protein expression;public health relevance;Rattus;Reader;reconstruction;recruit;Recurrence;Reporting;response;Role;Severities;Site;small molecule;Smoking;Societies;standard of care;subgingival microbiome;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic Effect;Tissues;Tooth Loss;Tooth structure;transcription factor;Transcription Initiation;Transcriptional Activation

PROJECT_TITLE: Epigenetic Regulation of Periodontal Inflammation

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Hypertension

PHR: Project Narrative The proposed research is relevant to public health because cardiovascular disease is a major cause of morbidity and mortality in this country. Much remains to be learned about the molecular mechanisms that control the vasculature and become deranged in vascular disease states characterized by oxidative stress, such as hypertension and diabetes. The proposed research enhances our understanding of the key cellular proteins that control blood vessel function, and may lead to the identification of new therapeutic targets.

PI_NAMEs: MICHEL, THOMAS  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Alanine;Amino Acids;Animal Genetics;Animal Model;Antioxidants;Biosensor;Blood Pressure;blood pressure control;Blood Vessels;Cardiomyopathies;Cardiovascular Diseases;Catalysis;Caveolae;Cell Nucleus;Cell Surface Receptors;Cells;cellular imaging;Clinical Trials;cofactor;Country;Cytosol;D-Amino Acid Dehydrogenase;Development;Diabetes Mellitus;Disease;Endothelial Cells;endothelial dysfunction;Endothelium;Experimental Models;experimental study;Functional disorder;Generations;Genetic;genetic approach;Genetic Transcription;Goals;Heart;Heart failure;hemodynamics;Homeostasis;Human;Hydrogen Peroxide;Hypertension;Image;imaging approach;In Vitro;in vivo Model;Intracellular Membranes;Investigation;Learning;Metabolism;Modeling;Molecular;Morbidity - disease rate;mortality;new therapeutic target;NF-kappa B;Nitric Oxide;Nitric Oxide Signaling Pathway;NOS3 gene;novel;Oxidants;Oxidation-Reduction;Oxidative Stress;P2Y2 receptor;Pathologic;Pathway interactions;Pharmaceutical Preparations;Phenotype;Phosphorylation;Physiological;Physiology;Post-Translational Protein Processing;Preparation;programs;Proteins;Public Health;Purinoceptor;Reactive Oxygen Species;Recombinants;Research;response;Role;shear stress;Signal Pathway;Signal Transduction;spectrograph;Technology;Testing;time use;Transcript;transcriptome;Transgenic Mice;Vascular Diseases;Vascular Endothelium;Work;Yeasts

PROJECT_TITLE: Hydrogen peroxide in endothelial function and dysfunction

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: The proposed research plan seeks to provide a better understanding of the mechanisms that contribute to impaired lymphangiogenesis, decreased arterial cholesterol removal and pathogenesis of atherosclerosis. Atherosclerosis and -related cardiovascular complications account for the majority of deaths in the United States, and are responsible for considerable burden on US health care delivery and its costs. Knowledge gained from the proposed project is expected to pave a foundation for future therapeutic studies to improve cholesterol removal from atherosclerotic arteries and prevent complications from atherosclerotic cardiovascular disease.

PI_NAMEs: SINGLA, BHUPESH  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Applications Grants;Arterial Fatty Streak;Arteries;Atherosclerosis;Attenuated;attenuation;Biological Assay;Biological Availability;Biology;Cardiovascular system;career;CD47 gene;Cells;Cessation of life;Cholesterol;cost;cytokine;detection method;Development;Endogenous Factors;Excision;Foundations;Future;Generations;Genetic;Goals;Grant;health care delivery;Human;Imaging Techniques;Impairment;improved;In Vitro;in vivo;Inflammatory;Knockout Mice;Knowledge;Link;Lipids;Lipoproteins;Lymphangiogenesis;Lymphatic;lymphatic drainage;Lymphatic Endothelial Cells;Lymphatic function;Lymphatic System;lymphatic vessel;MAPK3 gene;Mediating;Mentors;Methodology;Modeling;Molecular Biology;molecular imaging;multidisciplinary;Mus;Operative Surgical Procedures;Pathogenesis;PIK3CG gene;prevent;programs;Proteins;Publishing;receptor;Regulation;Research;research study;reverse cholesterol transport;Signal Transduction;Testing;Therapeutic Studies;Thrombospondin 1;Training;United States;uptake

PROJECT_TITLE: Regulation of Lymphangiogenesis by Thrombospondin 1

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Cost Effectiveness Research;Diabetes;Genetic Testing;Genetics;Health Services;Precision Medicine;Prevention

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: NARRATIVE Monogenic diabetes affects 100,000 or more Americans with diabetes, but many remain undiagnosed and are therefore often inappropriately treated. This study is designed to refine the application of genetic testing results to optimize longitudinal clinical outcomes for these single gene causes of diabetes and thereby serve as a model for precision diagnosis and treatment in all forms of diabetes.

PI_NAMEs: GREELEY, SIRI ATMA W.;PHILIPSON, LOUIS H. (contact)

PROGRAM_OFFICER_NAME: AKOLKAR, BEENA

PROJECT_TERMS: Acceleration;Address;Affect;Algorithms;American;cascade genetic testing;Chicago;Classification;Clinical;Clinical effectiveness;clinical practice;Cohort Studies;Collection;Communication;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost efficient;Data;Data Collection;data quality;design;Development;Diabetes Mellitus;diabetes mellitus genetics;Diagnosis;Dideoxy Chain Termination DNA Sequencing;Disclosure;Economic Burden;economic impact;efficacy evaluation;Enrollment;Ensure;Evaluation;exome sequencing;Family member;Focus Groups;follow-up;Funding;Future;gene discovery;gene-targeted therapy;Genes;genetic disorder diagnosis;genetic testing;genetic variant;Genotype;Goals;Grant;Guidelines;Health Personnel;Healthcare Systems;improved;Individual;Infrastructure;innovation;insight;Laboratories;Letters;Massive Parallel Sequencing;Methods;Modeling;Morbidity - disease rate;mortality;next generation;novel;novel strategies;Outcome;Participant;participant retention;Pathway interactions;patient engagement;Patient-Focused Outcomes;Patients;personalized diagnostics;personalized medicine;Persons;Phenotype;Play;precision medicine;preference;Probability;proband;Publications;Registries;Reporting;Research;Resources;retention rate;Role;satisfaction;screening;Structure;success;Surveys;Test Result;Testing;Time;transcriptome sequencing;type I and type II diabetes;United States;Universities;uptake;variant of unknown significance

PROJECT_TITLE: Monogenic Diabetes: Next Generation Diagnosis, Treatment and Complications

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Depression;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Telehealth

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: This proposed project will advance a brief, feasible digital health approach to detect anxiety and depressive disorders in young children using wearable sensors. If successful, this approach has the potential to identify young children who are suffering with mental illness. The proposed training plan will allow this applicant to contribute significantly to the emerging field of digital psychiatry as an independent investigator as a long-term career.

PI_NAMEs: MCGINNIS, ELLEN WAXLER (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adult;Age;American;Anxiety;Anxiety Disorders;Behavioral;career;Cellular Phone;Child;child depression;Childhood;childhood anxiety;Classification;Clinical;Cognitive;cognitive process;Communication;Competence;Complex;Data;Data Scientist;Dedications;Depressive disorder;design;Development;Diagnostic and Statistical Manual of Mental Disorders;digital;digital health;digital phenotyping;Disease;disease classification;early childhood;early screening;Educational Curriculum;Emotional;Engineering;Epidemiology;Ethics;evidence base;Foundational Skills;Foundations;Goals;Health;Health Status;Health system;Health Technology;Impairment;improved;innovation;instrument;Knowledge;Language;lens;Machine Learning;Measures;Medical center;Memory;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentorship;Methodology;mHealth;mobile app development;mobile application;Mobile Health Application;Modeling;Moods;Motion;Movement;multimodal data;National Institute of Mental Health;Negative Valence;new technology;New York;novel;Parents;Partnership Practice;pediatrician;Pediatrics;Performance;Phenotype;Positive Valence;Prevalence;programs;prototype;Psychiatry;Psychopathology;Public Health;Publishing;recruit;Reporting;Research;Research Domain Criteria;Research Personnel;research study;Sampling;Scientist;screening;Screening procedure;sensor;Services;sex;skills;skills training;social;Social Processes;Socialization;Specificity;Speech;System;Systems Analysis;Technology;Testing;tool;Training;Translating;Universities;Vermont;wearable sensor technology;Work

PROJECT_TITLE: Digital Phenotyping To Screen For Early Childhood Internalizing Disorders


NIH_SPENDING_CATS: Osteoporosis

ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Mineralization defects are common and cause osteoporosis, but what drives mineral production is complex and is not fully characterized. We identified ion transporters, chloride-proton and sodium-proton exchangers, that remove acid produced by mineral formation to drive synthesis of dense bone. We will determine how these transporters support bone formation, and the consequences when transporters are missing or dysfunctional.

PI_NAMEs: BLAIR, HARRY COLBERT (contact);NELSON, DEBORAH J.;SCHLESINGER, PAUL H

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Acids;Address;Affect;Aging;Air;Alkaline Phosphatase;Alkalinization;antiporter;Apatites;basolateral membrane;bone;Bone Matrix;Breathing;Calcium;Carbonates;cariporide;Carrier Proteins;Cell membrane;Cells;Chlorides;Collagen;Collagen Type I;Collagen Type II;Complex;cortical bone;Data;Defect;Deposition;Detection;Dyes;Elements;Epithelium;extracellular;Extracellular Fluid;Extracellular Matrix;fluorexon;genetic regulatory protein;Glycocalyx;Hydrogen;Hydroxyapatites;In Vitro;in vivo;inhibitor;innovation;inorganic phosphate;ionization;Ions;knock-down;Levamisole;live cell imaging;Measures;Membrane Proteins;Membrane Transport Proteins;Methods;mineralization;Minerals;Molecular;molecular targeted therapies;Nature;new therapeutic target;NHE1;Nodule;Normal Cell;novel;Organ;Oryctolagus cuniculus;Osteoblasts;Osteocalcin;Osteoclasts;Osteogenesis;Osteon;osteopontin;Osteoporosis;overexpression;Pathway interactions;pH gradient;phosphatase inhibitor;Physiologic calcification;Production;Protein Overexpression;Proteins;Protons;Regulation;Role;sensor;Sodium;sodium-hydrogen exchanger regulatory factor;spatiotemporal;Structure;Surface Plasmon Resonance;Testing;Therapeutic Intervention;therapeutic target;Time;Transmembrane Transport;transmission process;Transport Process;uptake;Vertebral column;Vertebrates;Visualization;Work

PROJECT_TITLE: Epithelial Osteoblast Function: The Role of Acid Transport

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ATLANTA

ORG_DEPT: GENETICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This study will analyze the mechanisms by which the three-dimensional organization of the genetic material in the nucleus is established and maintained. This organization is critical for the regulation of gene expression, and the results will be important to understand how transcription is controlled during stem cell differentiation or during reprograming of somatic cells. This knowledge will be essential to understand the basic biology of the cell nucleus and the origin of human genetic disease or cancer and could help guide the use of stem cell therapy to treat human diseases.

PI_NAMEs: CORCES, VICTOR G. (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3-Dimensional;Affect;Biological Models;Cell Differentiation process;Cell Nucleus;Cells;Cellular biology;Chromatin;Chromatin Fiber;cohesin;Complex;Computational Biology;computerized tools;Data;Disease;Drosophila genus;Enhancers;Environment;Epigenetic Process;epigenomics;Eukaryota;experimental study;Frequencies;Gene Expression;Gene Expression Regulation;Genetic;Genetic Diseases;Genetic Materials;Genetic Transcription;Genome;Hi-C;Homeostasis;human disease;human embryonic stem cell;Human Genetics;interdisciplinary approach;Knowledge;Learning;Logic;Machine Learning;Malignant Neoplasms;mammalian genome;Mammals;novel;Nuclear;Pancreas;promoter;protein complex;Proteins;Resolution;Role;scaffold;Site;Somatic Cell;stem cell differentiation;stem cell therapy;Testing;Three-dimensional analysis;Tissues;Transcription Process;Transcriptional Regulation;Vertebrates;Work

PROJECT_TITLE: Nuclear Organization and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Whooping cough (pertussis) is a re-emerging public health crisis responsible for the death of over 150,000 infants annually. We have identified a currently licensed drug that protects against disease, but has off-target effects. We have identified 3 proteins, one of which is produced by mice in response to this drug, the other two are blocked by the drug, which we believe may control symptoms associated with disease.

PI_NAMEs: SKERRY, CIARAN  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Agonist;airway epithelium;Amplifiers;anti-microbial peptide;Antibiotic Therapy;Antibiotics;antimicrobial;associated symptom;Attenuated;bactericide;Binding;Biological Assay;Biosensor;Bordetella pertussis;Cause of Death;Cell Separation;cell type;Cells;Cessation of life;Characteristics;Communicable Diseases;Complex;Core Facility;Coughing;cytokine;cytotoxic;Cytotoxin;Data;Development;differential expression;Disease;Elements;Equilibrium;Family;Flow Cytometry;Genes;Goals;Gram-Negative Bacteria;Immunization Programs;in vitro Assay;Infant;Inflammation;Inflammatory;Inflammatory Response;inhibitor;insight;Kinetics;Knockout Mice;Licensing;Ligands;Lung;Mass Vaccinations;Measures;Mediating;Mus;Myeloid Cells;next generation;novel therapeutics;Papio;Pathogenesis;Pathology;Pattern recognition receptor;Peptidoglycan;peptidoglycan monomer;peptidoglycan recognition protein;Pertussis;Pharmaceutical Preparations;prevent;Proteins;Public Health;Pulmonary Inflammation;Pulmonary Pathology;receptor;Receptor Activation;Recombinants;response;Role;single-cell RNA sequencing;Sphingosine-1-Phosphate Receptor;Testing;Therapeutic;Tissues;Trachea;transcriptomics;Virulence Factors;Work

PROJECT_TITLE: Pertussis inflammation is mediated by a balance between peptidoglycan recognition proteins-1 and -4

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Public Health Relevance: Malaria is a major public health problem, particularly in sub- Saharan Africa. Advancements in molecular biology, bioinformatics, modeling and other disciplines provide exciting opportunities to develop new vector control tools. The vast majority of scientists from malaria-endemic Africa have not been able to use these new technologies to their maximum potential. Training next generation scientists to enable them to effectively use the new technologies and enhancing the malaria research capacity from malaria-endemic Africa will greatly facilitate the malaria control efforts in Africa.

PI_NAMEs: YAN, GUIYUN  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;Africa;African;Agriculture;Behavior;Behavioral;Bioinformatics;Biology;Biometry;Bite;California;career development;Career Mobility;Country;Culicidae;Deforestation;Development;doctoral student;Educational Curriculum;Educational workshop;Effectiveness;empowerment;environmental change;Environmental Impact;Epidemiology;Ethiopia;Evaluation;experience;Genomics;Goals;Infrastructure;Insecticide Resistance;Insecticides;International;Intervention;Irrigation;Kenya;Knowledge;Laboratories;Malaria;Methods;Modeling;Modification;Molecular Biology;new technology;Parasites;Population Biology;Postdoctoral Fellow;programs;Research;Residual state;Resistance development;responsible research conduct;Scientist;Site;tool;Trainers Training;Training;Training Programs;Universities;Urbanization;vector;vector control;Vector Ecology;Vector-transmitted infectious disease;Writing

PROJECT_TITLE: Population Biology of African Malaria Vectors and Parasites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Z(55)R]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Kidney Disease;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE: Urinary tract infections (UTIs) and catheter associated UTIs are common and increasingly antibiotic resistant. Thus, a high resolution understanding of the mechanisms of host-pathogen interactions is needed to spawn the development of new antibiotic-sparing therapeutics that interrupt interactions necessary for virulence. Thus, we will elucidate structure-function correlates of a repertoire of chaperone usher pathway (CUP) pilus adhesins encoded by the most common uropathogen, uropathogenic E. coli, and CUP adhesins encoded by Acinetobacter baumanii, a frequently multidrug pathogen that causes increasing numbers of opportunistic infections. The receptor specificity, structures and dynamics of CUP adhesins will transform the field by providing a new conceptual framework in microbial pathogenesis focused on events critical to host colonization and uncovering new therapeutic strategies to treat or prevent disease.

PI_NAMEs: HULTGREN, SCOTT J. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acinetobacter;Acute Cystitis;Adhesions;Adhesives;Affect;Affinity;Alleles;antagonist;Antibiotic Prophylaxis;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Bacteria;Bacterial Adhesins;Bacterial Infections;Binding;Biological Assay;Biology;Bladder;Bladder Tissue;C-terminal;catheter associated UTI;Catheterization;Catheters;Cells;Cessation of life;Chronic Cystitis;Clinical;Clinical Trials;combat;Communicable Diseases;conformational conversion;conformer;Cryoelectron Microscopy;Crystallography;Cystitis;Deposition;Deterioration;Development;Disease;drug resistant pathogen;Economic Burden;Enzyme-Linked Immunosorbent Assay;Epithelium;Equilibrium;Escherichia coli;Escherichia coli Adhesins;Event;experience;Fiber;Fibrinogen;Fimbriae Proteins;Galactose;Genome;Glycoproteins;Gram-Negative Bacteria;gut colonization;Habitats;Health Care Costs;host colonization;Human;Implant;Infection;Ingestion;insight;Interruption;Invaded;ion mobility;Kidney;kidney infection;Lectin;Ligand Binding;Ligands;Link;Mannose;Mannosides;Measures;Mediating;Medicine;Meningitis;microbial;Microbial Biofilms;microbiota;Mission;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;molecular dynamics;mouse model;Multi-Drug Resistance;multi-drug resistant pathogen;Multiple Bacterial Drug Resistance;Mutagenesis;mutant;N-terminal;novel;novel therapeutic intervention;Operon;Opportunistic Infections;Pain;pan-genome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Pilum;Plants;Play;Polysaccharides;Predisposition;prevent;Quality of life;receptor;receptor binding;Recurrence;Resolution;Resort;Roentgen Rays;Role;Sampling;Scanning;small molecule;Specificity;Structure;Surface;System;Testing;Therapeutic;therapeutic target;tissue tropism;Tissues;trait;Tropism;urinary;Urinary tract;Urinary tract infection;Uropathogen;Uropathogenic E. coli;Vegetables;Virulence;Woman;women's diagnosis

PROJECT_TITLE: Pathogenic Fiber Formation in Bacteria: Structural Basis

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Cleft lip with or without cleft palate (CL/P) represents the most common craniofacial birth defect and is a burden for the individual and society. I will investigate the cell behaviors, genetic pathways, and regulatory networks underlying facial prominence fusion to identify new genes that will enable rapid prenatal diagnostics and tissue repair of CL/P.

PI_NAMEs: CHACON, BRANDON HUGH (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Adult;Affect;Apoptosis;Bromodeoxyuridine;cell behavior;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;Cell Cycle Regulation;Cells;Cephalic;Cicatrix;Cleft Lip;Cleft lip with or without cleft palate;Cleft Palate;Congenital Abnormality;craniofacial;Cytometry;Dental;Development;Diagnostic;Dissection;Distal;Down-Regulation;Ectoderm;Effector Cell;Embryo;Embryonic Development;Epithelial Attachment;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Excision;Exhibits;Face;Failure;Flow Cytometry;Gene Expression;Gene Targeting;gene therapy;Genes;Genetic;Health;Heterogeneity;Human;improved;in vivo;in vivo evaluation;Incentives;Individual;Infant;Label;Lateral;Link;Lip structure;malformation;Malnutrition;Maxillary Prominence;Medial;Mesenchyme;Molecular;Molecular Profiling;Morphogenesis;mouse model;Mus;mutant;Names;Nasal Prominence;Neural Crest;novel;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patients;phase change;Phenotype;Play;Population;Premaxillary palate;prenatal;Prenatal Diagnosis;prevent;Prevention;Process;repaired;Research;Risk;Role;single-cell RNA sequencing;Site;Societies;spatiotemporal;Speech Pathology;suckling;Surface;System;Testing;tissue repair;Tissues;Transcript;transcriptomics;United States;Up-Regulation;Validation;Wild Type Mouse

PROJECT_TITLE: Cell cycle regulation in the cephalic epithelium as a driver of midface morphogenesis

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative This project seeks to characterize interleukin-1 (IL1)-related inflammatory signatures in the blood and intestinal tissue of patients with inflammatory bowel disease (IBD), interleukin-10 receptor (IL10R) deficiency, and in healthy controls, using a combination of proteomic and transcriptomic single cell approaches. IL10R-deficiency is a monogenic form of very-early-onset IBD characterized by enhanced IL1 expression and can be responsive to IL1 blockade, a treatment relatively unexplored in IBD. A deep understanding of IL1-associated inflammatory signatures in IBD at large will help not only improve our understanding of IBD pathogenesis but identify subsets of patients with enhanced IL1 expression, similar to IL10R-deficiency, who may have disease amenable to treatment with anti-IL1 therapy.

PI_NAMEs: MITSIALIS, VANESSA  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Affect;Anus;Biological Response Modifier Therapy;Blood;Cells;Chronic;Clinical;cohort;Colitis;Crohn's disease;cytokine;Cytometry;Data;Data Set;Development;Disease;disease phenotype;disorder subtype;early onset;Environmental Risk Factor;Family;Gastroenterology;Genes;Genetic;gut microbes;Human;Immune;Immunophenotyping;improved;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Interleukin-1;interleukin-10 receptor;Interleukin-12;Intestinal Mucosa;Intestines;Investigation;Life;Macrophage;Mediating;Morbidity - disease rate;Mucositis;Mucous Membrane;Mus;Myelogenous;Pathogenesis;patient subsets;Patients;Peripheral;Phenotype;Phosphorylation;Play;Population;population based;Production;prospective;protein expression;proteomic signature;Proteomics;receptor;recruit;Refractory Disease;response;Role;Sampling;Severities;Signal Transduction;single cell analysis;single-cell RNA sequencing;Stem cell transplant;Technology;Testing;Therapeutic;therapeutic target;Tissues;TNF gene;trafficking;transcriptomics;Ulcerative Colitis;Validation;Work

PROJECT_TITLE: IL1 as a Driver of Mucosal Immune Dysregulation in Inflammatory Bowel Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Vascular repair after ischemic stroke is critical for functional recovery. It is unclear how inflammation regulates these repair processes. The proposed studies will investigate the impact of endogenous type I interferon signaling on longitudinal cerebrovascular function after ischemic brain injury and has the potential to pave the road for therapeutic modulation of inflammatory pathways to improve recovery after ischemic stroke.

PI_NAMEs: TUOHY, MARY CLAIRE  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Ablation;angiogenesis;beta catenin;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier function;Brain;brain endothelial cell;Brain Ischemia;candidate validation;Cause of Death;Cell Physiology;Cells;Central Nervous System;central nervous system vasculature;Central Nervous System Viral Diseases;Cerebral Infarction;cerebrovascular;Chronic disability;Clinical;Confocal Microscopy;Data;Development;Disease;Endothelial Cells;Flow Cytometry;Fluorescent in Situ Hybridization;Functional Imaging;functional improvement;Future;Genetic;Genetic Transcription;hemodynamics;Homeostasis;Hour;Hyperemia;IFNAR1 gene;Immune;immune cell infiltrate;Immunofluorescence Immunologic;immunoregulation;improved;in vivo;in vivo imaging;Infarction;Infection;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Innate Immune Response;Interferon Activation;Interferon Receptor;Interferon Type I;Interferons;Investigation;Ischemia;Ischemic Brain Injury;ischemic injury;Ischemic Stroke;Knock-out;Knowledge;Maps;Mediating;microbial;Microglia;Molecular;monocyte;mouse model;Mouse Strains;Multiple Sclerosis;Mus;Myeloid Cells;novel;Pathway interactions;Pattern;Peripheral;Process;Receptor Signaling;Recovery;Recovery of Function;recruit;repaired;response;restoration;RNA;Rodent;Role;Rose Bengal;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sterility;Structure;Survivors;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;tissue injury;tissue repair;Transgenic Organisms;tumor microenvironment;two photon microscopy;Up-Regulation;Validation;Vascular remodeling;Work

PROJECT_TITLE: Type I Interferon Mediated Restoration of Brain Endothelial Cell Function after Cerebral Infarction


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

ORG_CITY: Columbus

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Skeletal muscle is central to the development of metabolic dysfunction during type 2 diabetes and obesity. Thus, it is critical to identify and target molecular networks that preserve or restore muscle function. Our proposed studies have identified a novel mechanism for the sensing of glucose that controls muscle fitness and growth.

PI_NAMEs: KYRIAZIS, GEORGE  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Ablation;Acceleration;Actins;Address;Adult;Attenuated;Bioenergetics;Biological Availability;blood glucose regulation;Cell Lineage;Cells;Cellular Metabolic Process;Data;Deacetylase;defined contribution;detection of nutrient;Development;Diabetes Mellitus;diet-induced obesity;Endocrine;Energy Metabolism;Equilibrium;Etiology;Exercise Tolerance;Fasting;fitness;FRAP1 gene;Fructose;functional adaptation;Functional disorder;G-Protein-Coupled Receptors;Genes;Genetic;Glucose;glucose sensor;glucose tolerance;Growth;Growth and Development function;Heterodimerization;Hormonal;Human;Hypertrophy;Immobilization;improved;in vivo;Ingestion;inhibitor;Innovative Therapy;Insulin;Insulin Resistance;Intramuscular;Isotope Labeling;knock-down;Knockout Mice;Limb structure;Link;Maintenance;MAPK1 gene;Measures;Mechanics;Mediating;Metabolic;Metabolic Control;Metabolic dysfunction;Metabolic Pathway;Metabolism;Mitochondria;Molecular;Molecular Target;Morphology;Mus;Muscle;muscle degeneration;Muscle Development;muscle form;Muscle function;muscle hypertrophy;Muscular Atrophy;Myogenin;Neurons;Nicotinamide adenine dinucleotide;Non-Insulin-Dependent Diabetes Mellitus;novel;nucleic acid biosynthesis;Nucleotide Biosynthesis;Nutrient;Obese Mice;Obesity;obesity genetics;Outcome;oxidation;Oxidation-Reduction;Pathogenesis;Pathway interactions;pharmacologic;Pharmacological Treatment;Phenotype;Physiological;pleiotropism;Poly(ADP-ribose) Polymerases;Polymerase;postnatal;preservation;prevent;Prevention therapy;Process;Protein Biosynthesis;Proteins;Protocols documentation;Reaction;receptor;Receptor Signaling;Regulation;Reporter;Reporting;response;Role;sensor;Signal Pathway;Signal Transduction;SIRT1 gene;Sirtuins;skeletal;Skeletal Muscle;skeletal muscle plasticity;skeletal muscle wasting;spatiotemporal;Stimulus;sweet taste perception;Taste Buds;Testing;Thinness;Tongue;treatment response;uptake

PROJECT_TITLE: Receptor-mediated glucose sensing and skeletal muscle function

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: HARTFORD

ORG_NAME: HARTFORD HOSPITAL

PHR: This project will test a model of etiological diversity related to the brain's reward system in Attention Deficit/Hyperactivity Disorder (ADHD). Our detailed phenotyping will use test scores and metrics derived via computational modeling diverse forms of reward behavior in many different experimental contexts. Our biotyping analyses will characterize the expression of different profiles of reward behavioral and neural system dysfunction in ADHD. In addition to testing hypotheses with potentially paradigm-shifting significance for ADHD etiology and translational research, this project will create and disseminate an information-rich database resource of reward dysfunction in ADHD for widespread scientific community use.

PI_NAMEs: STEVENS, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Age;Anterior;Architecture;Attention deficit hyperactivity disorder;Behavior;behavior influence;behavior prediction;behavior test;Behavioral;biotypes;Brain;brain behavior;causal model;Choice Behavior;Classification;Communities;Complex;Computer Models;Corpus striatum structure;cost;Costs and Benefits;Data;data fusion;Databases;Decision Making;design;Development;Diagnosis;Diagnostic;discounting;Disease;Disparate;Dorsal;DSM-V;Etiology;Expenditure;falls;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Heterogeneity;Impairment;Individual;Individual Differences;interest;Learning;learning network;Link;Maps;Measures;Methodology;Methods;Modeling;network architecture;neural;Neurobiology;Neurocognitive;Neurocognitive Deficit;neurodevelopment;Neurosciences;Normal Statistical Distribution;novel;Pathway interactions;Patients;Phenotype;predictive modeling;Prefrontal Cortex;Prevalence;Psychological reinforcement;Reaction Time;Research Domain Criteria;Resources;Rest;reward dysfunction;Rewards;Sampling;sex;Signal Transduction;Subgroup;Symptoms;System;Testing;therapy development;Time;Translational Research;Ventral Striatum

PROJECT_TITLE: Computational Modeling-Informed Reward Subgroups in Adolescent ADHD

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Age-related macular degeneration (AMD) is the leading cause of irreversible blindness among elderly Americans, which has a devastating effect on quality of life and is an escalating socioeconomic burden. To address this high priority area of the National Eye Institute (Intersection of Aging & Biological Mechanisms of Eye Disease) and the National Institute on Aging (Improve Understanding of Healthy Aging and Disease), our experiments are designed to study the biology of RPE exosomes, a component of the endocytic pathway that is dysregulated in AMD. Significantly, we will use RPE exosomes as biological displays of RPE health and behavior during AMD progression.

PI_NAMEs: HERNANDEZ, BELINDA J (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Age;age related;Age related macular degeneration;Aging;aging related;American;Apical;Area;Behavior;Biological;Biological Response Modifier Therapy;Biology;Blindness;Blood;Blood-Retinal Barrier;Bruch's basal membrane structure;Cell Culture Techniques;Characteristics;Cholesterol;Choroid;Circulation;Clinical;Collagen;Complement;Complement Factor H;Complex;Deposition;Detection;Developed Countries;Development;Diet;Disease;Disease Progression;Drusen;Early Diagnosis;Economic Burden;Elastin;Elderly;Endosomes;environmental stressor;exosome;Experimental Designs;Exposure to;Extracellular Matrix;extracellular vesicles;Eye;Eye diseases;Family suidae;Fatty acid glycerol esters;Frequencies;Functional disorder;gene therapy;Genetic;genetic approach;Genetic Risk;Goals;Health;healthy aging;improved;In Vitro;in vivo;Inflammation;insight;Intervention;Label;Link;Lipids;Lipoproteins;Maintenance;MicroRNAs;Modeling;Molecular;monolayer;mouse model;Mus;nanovesicle;National Eye Institute;National Institute on Aging;Natural regeneration;novel;novel virus;Onset of illness;Oxidative Stress;oxidized lipid;particle;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Photoreceptors;Plasma;Process;Protein Secretion;Proteins;Quality of life;response;Retina;Retinal Degeneration;Retinal Diseases;Retinal Pigments;Risk Factors;risk variant;Role;Side;socioeconomics;solute;Stress;stressor;Structure of retinal pigment epithelium;Testing;Therapeutic;Therapeutic Intervention;Urine;Vision

PROJECT_TITLE: RPE Exosomes in Age-related Macular Degeneration


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Immunization;Infectious Diseases;Liver Disease;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE  Live-attenuated Plasmodium parasite vaccines confer sterilizing immune protection against liver infection via CD8+ T cells, yet their molecular biological and immunological features that elicit this response and the target MHC class I epitopes of liver stage parasites remain largely unknown. We will elucidate protective features of replication-competent parasite vaccines and directly identify MHCI-restricted liver stage antigens from the surface of infected hepatocytes. This will allow us to build next generation vectored subunit vaccines as well genetically engineer optimally safe and potent live-attenuated vaccines.

PI_NAMEs: KAPPE, STEFAN HI (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acceleration;Address;Animal Model;Antigen Presentation;Antigen-Presenting Cells;Antigens;Attenuated;Attenuated Vaccines;attenuation;Basic Science;Behavior;Biological;Biological Assay;Biology;Biomass;Categories;CD8-Positive T-Lymphocytes;Cell Cycle Kinetics;cell killing;Cell Separation;Cells;Cellular biology;Cessation of life;Clinical Trials;CRISPR/Cas technology;Cross Presentation;Data;design;Development;Dominant-Negative Mutation;Ensure;Epitopes;Erythrocytes;Gene Deletion;Generations;Genetic Engineering;Genome engineering;genomic locus;Hepatocyte;Human;Immune;Immune response;Immunity;Immunization;Immunize;immunogenicity;Immunologics;In Vitro;Infection;Knowledge;Liver;liver infection;Malaria;malaria infection;Malaria Vaccines;Mediating;MHC Class I Genes;Modeling;Molecular;Mus;next generation;overexpression;parasite genome;Parasites;Peptides;Phase;Plasmodium;Plasmodium falciparum;Plasmodium falciparum vaccine;Plasmodium vaccine;Plasmodium yoelii;Predisposition;Process;promoter;Proteins;Proteome;Proteomics;Radiation;response;Rodent;Sporozoites;Subunit Vaccines;Surface;Surface Antigens;T cell response;T-Cell Activation;T-Lymphocyte Epitopes;Technology;Testing;Time;Tissues;tool;transcriptome;Transgenes;Translational Research;Vaccination;vaccine candidate;Vaccine Design;vaccine efficacy;vaccine immunogenicity;Vaccines;vector;vector vaccine;Viral Vector;Work

PROJECT_TITLE: Biologically informed design of CD8+ T cell-dependent pre-erythrocytic stage malaria vaccines


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Congenital Structural Anomalies;Genetics;Hydrocephalus;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative Neurodevelopmental disorders, including autism spectrum disorder, have increasing prevalence amongst children in the United States, yet there are no pharmacological treatments targeting the core symptoms. To understand the molecular mechanisms underlying these disorders, we must examine the function of high confidence risk genes, such as PTEN, in the developing brain. By uncovering the cellular and molecular changes effected by PTEN loss in neurodevelopment, we can identify targetable points for new pharmacological treatment to improve patient outcomes.

PI_NAMEs: CARLSON, MARINA ALISE (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Affect;Alleles;autism spectrum disorder;autistic children;Automobile Driving;Behavior;Behavior Therapy;Behavioral;behavioral phenotyping;Biological;Brain;brain volume;Cell Cycle;Cell Differentiation process;cell growth;Cell Proliferation;Cells;Cerebral Ventricles;Child;Childhood;Clinical;Computer software;Congenital Hydrocephalus;CRISPR/Cas technology;Data;Disease;disorder risk;Drug Targeting;early childhood;Embryo;Exhibits;exome sequencing;Exons;Fertility;fetal;Fishes;Frameshift Mutation;FRAP1 gene;Gene Dosage;Genes;Genetic;genetic variant;Genome;Goals;Head circumference;Heterozygote;high-throughput drug screening;Human;Human Pathology;Immunohistochemistry;improved;in vivo;inhibitor;Injections;insight;Investigation;Larva;Libraries;Liquid substance;loss of function;Macrocephaly;member;Messenger RNA;Metabolic Pathway;Methods;Modeling;Molecular;mTOR Signaling Pathway;mutant;Mutation;neural;neural circuit;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neurons;new therapeutic target;novel;novel strategies;Operative Surgical Procedures;Outcome;Outcomes Research;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patient-Focused Outcomes;pharmacologic;Pharmacological Treatment;Phenotype;Play;pleiotropism;Pre-Clinical Model;Prevalence;Process;Proliferating;Protein Biosynthesis;protein protein interaction;Proto-Oncogene Proteins c-akt;PTEN gene;Reporting;Research;Rest;risk variant;Role;screening;Screening procedure;Sirolimus;Startle Reaction;Symptoms;System;targeted treatment;teleost;Testing;United States;Variant;Western Blotting;Zebrafish

PROJECT_TITLE: Functional Analysis of Pathogenic Human PTEN Variants in Early Neurodevelopment


NIH_SPENDING_CATS: Diabetes

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project narrative Diabetes is a major public health crisis involving both dysregulation of islet hormone secretion with many current β-cell targeted therapies having limited success that decreases with sustained use. Therefore, innovative ideas that focus on novel mechanisms for regulation of blood glucose are necessary to create new therapeutics. In this proposal, the goal is to identify how anaplerotic fuels regulate α-cell metabolism and secretion in order to uncover new therapeutic pathways to treat the approximately 1 in 10 Americans with diabetes.

PI_NAMEs: KNUTH, EMILY  (contact)

PROJECT_TERMS: Adult;Affect;Alpha Cell;American;Amino Acids;Beta Cell;Biological Assay;Biosensor;Blood Glucose;blood glucose regulation;Calcium;Cell membrane;Cell Physiology;Cell secretion;Cellular Metabolic Process;Characteristics;combat;Cyclic AMP;D Cells;Data;Defect;Diabetes Mellitus;Diagnosis;Disease;Enzymes;experimental study;Failure;Genetic;Genetic Models;Glucagon;Glucose;Goals;Hormone secretion;Hormones;Human;Hypoglycemia;impaired glucose tolerance;improved;in vivo;innovation;insight;Insulin;insulin secretion;Intervention;islet;Islets of Langerhans;Knock-out;Learning;Leucine;Light;Mediating;metabolic abnormality assessment;Metabolism;Microscopy;Mitochondria;Modeling;mouse model;Mus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nutrient;Organ;Oxaloacetates;pancreatic juice;paracrine;Paracrine Communication;Pathway interactions;Persons;Phosphoenolpyruvate;Phosphoenolpyruvate Carboxylase;Play;Prediabetes syndrome;Public Health;Pyruvate Kinase;Regulation;response;Role;Second Messenger Systems;Signal Transduction;Somatostatin;success;targeted treatment;Techniques;Testing;Therapeutic;Total Internal Reflection Fluorescent;Training;United States

PROJECT_TITLE: Regulation of alpha-cell glucagon secretion by mitochondrial anaplerosis-cataplerosis


NIH_SPENDING_CATS: Infectious Diseases;Nutrition

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE Results from these studies will yield mechanistic insight into how vertebrates defend against infection through the sequestration of nutrient metals. In addition, this research will reveal how bacterial pathogens respond to nutrient restriction through coordinated changes in gene expression and controlled allotment of scarce metal to critical metalloproteins positioned at metabolic hubs. The conserved importance of these processes across all bacteria will enable our results to be extrapolated to multiple human pathogens and may lead to the development of new therapeutics for the treatment of infectious diseases.

PI_NAMEs: SKAAR, ERIC P (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Abscess;Antibiotic Resistance;Antibiotics;antimicrobial;Area;Bacteria;Bacterial Infections;Binding;Cells;chelation;Client;cofactor;combat;Coupled;Dedications;defined contribution;deprivation;Development;DNA Repair;Ensure;Environment;Enzymes;Evaluation;experience;experimental study;Exposure to;Family;Gene Expression;Genome;Genus staphylococcus;Heterogeneity;Host Defense;human pathogen;Image;Imaging technology;Immune;Immune system;Immunologic Factors;immunoregulation;Individual;Infection;infectious disease treatment;Inflammatory;innovation;insight;Invaded;Iron;Knowledge;Leukocyte L1 Antigen Complex;Maintenance;Manganese;Mediating;member;Metabolic;Metalloproteins;Metals;microbial;Modeling;Molecular;Morbidity - disease rate;mortality;novel therapeutics;Nutrient;Nutritional Immunity;Nutritional Requirements;Oxygen;pathogen;Pathogenesis;pathogenic bacteria;pathogenic microbe;Phagocytes;Physiology;Positioning Attribute;Process;Property;Proteins;Public Health;recruit;Research;Resistance;resistant strain;response;Role;Site;Staphylococcus aureus;Staphylococcus aureus infection;Starvation;Stress;System;Testing;Therapeutic;therapeutic development;United States;Up-Regulation;Vertebrates;Work;Zinc

PROJECT_TITLE: The Staphylococcus aureus response to nutrient zinc restriction during infection


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE STATEMENT Adult stem cells have wide-ranging clinical potential to facilitate tissue regeneration. However, lack of approaches to precisely control stem cell functions has resulted in variable clinical efficacy. This proposal aims to develop an approach to encapsulate single cells with tunable matrix properties for understanding the fundamental mechanisms that direct growth, mechanics and differentiation of adult stem cells, which can be leveraged to design single stem cell encapsulation therapy for improved regenerative outcomes.

PI_NAMEs: SHIN, JAE-WON  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: 3-Dimensional;Ablation;Address;adult stem cell;Alginates;Animal Model;Biocompatible Materials;Biological;Biological Assay;biophysical model;biophysical techniques;Biophysics;Bone Regeneration;Cell Volumes;Cells;Clinical;clinical efficacy;Clinical Trials;clinically relevant;Cues;Data;Deposition;design;Disease;Elasticity;Encapsulated;Engineering;Femur;Formulation;fos-related antigen 1;Gel;Gene Expression Profiling;Genetic;Genetic Transcription;Growth;Heterogeneity;Hydrogels;Image;imaging modality;improved;in vivo;Individual;Injections;injured;insight;instrumentation;Integrins;interdisciplinary approach;Ion Channel;Kinetics;knock-down;Ligands;Marrow;mathematical model;Measures;Mechanics;Mediating;member;Membrane;Membrane Potentials;Mesenchymal Stem Cells;Microfluidics;mouse model;multidisciplinary;Natural regeneration;novel;Osteogenesis;osteogenic;Outcome;Pathway Analysis;Population;Production;programs;Property;public health relevance;receptor;regenerative;Reporting;Reproducibility;Research Personnel;response;RGD (sequence);Role;Small Interfering RNA;Specific qualifier value;stem cell differentiation;stem cell expansion;stem cell fate;stem cell function;stem cell growth;stem cell therapy;stem cells;Stress;Technology;Testing;Therapeutic;therapy outcome;Thinness;tissue regeneration;Tissues;transcription factor;transcriptome;Validation;Vanilloid;viscoelasticity;Work

PROJECT_TITLE: Engineering microscale hydrogel deposition to direct single stem cell differentiation

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Aging;Batten Disease;Brain Disorders;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

PHR: PROJECT NARRATIVE Neuronal Ceroid Lipofuscinosis type 1 (CLN1) is a devastating pediatric neurodegenerative disease characterized by the accumulation of lipofuscin, an autofluorescent lysosomal storage material that also builds up in the brain with normal and pathological aging. This project seeks to uncover fundamental molecular mechanisms that link CLN1-associated and age-associated lipofuscin with the long-term goal of identifying therapeutic targets for neurodegeneration.

PI_NAMEs: TIEZE, SOFIA MASSARO (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;Age;age effect;age related;aged;Aging;base;Biochemical;Biological Assay;Blindness;Brain;Carbohydrates;Cathepsins;causal variant;Characteristics;Chemicals;Chemistry;Child;Childhood;Clinical;common symptom;Complement;CRISPR/Cas technology;Cycloheximide;Data;Data Set;Disease;Disease Progression;Dissection;Electron Microscopy;enzyme deficiency;Enzymes;Etiology;Exhibits;experimental study;Family;galactosylgalactosylglucosylceramidase;Gel;Genetic;Goals;Human;Hydrolase;Hydroxylamine;immunocytochemistry;Immunoprecipitation;Impaired cognition;Impairment;In Situ;In Vitro;infancy;Ions;Kinetics;Knockout Mice;Label;Link;Lipids;Lipofuscin;live cell imaging;loss of function mutation;lysosomal proteins;lysosome membrane;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Membrane;Membrane Proteins;Mentorship;Metals;Modification;Molecular;Monitor;Motor;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neuronal Ceroid-Lipofuscinosis;Neurons;neuropathology;normal aging;novel;Other Genetics;Palmitates;palmitoylation;Pathogenesis;pathological aging;Pathology;Patients;Phospholipids;Preparation;Protein Sortings;protein transport;Proteins;Proteome;Proteomics;Recombinants;Research;Resolution;Retina;Retinal Degeneration;Role;Seizures;Slice;Spectrometry, Mass, Secondary Ion;Symptoms;Synapses;Techniques;Testing;therapeutic target;therapy development;thioesterase PPT1 gene product;Time;trafficking;Training;tripeptidyl aminopeptidase;Up-Regulation;Western Blotting

PROJECT_TITLE: Molecular characterization of lipofuscin pathology in neuronal ceroid lipofuscinosis


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The emergence of induced pluripotent stem cell (iPSC) technology offers an experimental human-based platform to predict and model chemotherapy-induced cardiotoxicity. The goal of this project is to study the role of the endothelium in the pathogenesis of doxorubicin-induced cardiotoxicity using bioengineering tools and next generation sequencing. Results from this work could potentially lead to new strategies that could lower morbidity and mortality, but also improve the management of cardiotoxicity patients.

PI_NAMEs: SAYED, NAZISH  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: 3-Dimensional;Acute;Address;Affect;Aftercare;Animal Model;Anthracycline;Antineoplastic Agents;Atherosclerosis;Attention;Biochemical;Biomedical Engineering;Calcium;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiomyopathies;Cardiotoxicity;Cardiovascular Physiology;Cardiovascular system;cell injury;cell type;Cells;chemotherapy;Chromatin;Chromosome Mapping;Chronic;Coculture Techniques;Collaborations;Communication;Complex;Computational Biology;CRISPR/Cas technology;Data;Development;Dose;Doxorubicin;Endothelial Cells;endothelial stem cell;Endothelium;Environment;Exhibits;Exposure to;Functional disorder;Gene Deletion;Gene Expression;gene regulatory network;Generations;genome editing;Genomic DNA;Goals;Health;Heart;heart cell;Heart failure;Human;human induced pluripotent stem cells;Impairment;improved;in vivo;induced pluripotent stem cell;induced pluripotent stem cell technology;insight;interdisciplinary approach;Kinetics;Knowledge;Left Ventricular Ejection Fraction;Ligands;Malignant Neoplasms;mechanical properties;Mediating;Membrane;Mitochondria;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mus;Muscle Cells;Myocardial dysfunction;myocardial injury;next generation sequencing;novel;Oncology;Organ;paracrine;Paracrine Communication;Pathogenesis;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiology;Play;Positioning Attribute;promoter;Reactive Oxygen Species;receptor;Research Personnel;response;Role;side effect;Signal Transduction;single cell ATAC-seq;single cell technology;single-cell RNA sequencing;Site;stem cell biology;Therapeutic;tool;Topoisomerase II inhibition;transcription factor;Trastuzumab;Type I DNA Topoisomerases;Vascular Diseases;Wing;Work

PROJECT_TITLE: Unraveling the role of endothelium in chemotherapy-induced cardiotoxicity

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: NARRATIVE Despite available treatments that are effective (naloxone), annual opioid overdose deaths surpassed 75,000 for the first time in 2021, with 87% of these deaths involving synthetic opioids such as fentanyl. This study will use whole-body plethysmography to characterize the nature of interactions between opioid drugs, determining the effects of mixtures of opioid agonists (heroin, fentanyl, carfentanil) on ventilation as well as the abilities of mixtures of opioid receptor antagonists (naloxone, diprenorphine, and the novel opioid receptor antagonist methocinnamox) to reverse the ventilatory depressive effects of opioids in rats. Findings from this study will determine whether combinations of opioid agonists have greater effects than each drug alone, and whether mixtures of opioid antagonists may be more effective than naloxone alone for treating opioid overdose.

PI_NAMEs: FLYNN, SHAWN MICHAEL (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: Accounting;Address;Agonist;Allosteric Site;analog;antagonist;Binding;career;carfentanil;Cessation of life;Characteristics;Clinical;Dangerousness;Data;depressive symptoms;design;Development;Diprenorphine;Dose;Drug Interactions;Drug Kinetics;Effectiveness;exposed human population;Exposure to;FDA approved;Fentanyl;fentanyl analog;Heroin;Human;improved;In Vitro;Knowledge;Laboratories;lipophilicity;Mediating;Metabolic Pathway;Methocinnamox;Methods;Morphinans;mu opioid receptors;Naloxone;naloxone dosing;Naltrexone;Nature;novel;Opioid;Opioid agonist;Opioid Antagonist;opioid mortality;opioid overdose;Overdose;overdose death;Overdose reversal;overdose risk;Pharmaceutical Preparations;Pharmacology;Phase;pre-clinical research;preclinical study;prescription opioid;Primates;Procedures;Property;Public Health;Rattus;Reporting;Research;Research Personnel;Risk;Rodent;Role;Site;skills;synthetic opioid;Testing;Time;Training;trend;United States;ventilation;Ventilatory Depression;Whole Body Plethysmography

PROJECT_TITLE: Reversal of ventilatory depression by drug mixtures


ORG_STATE: MA

PHR: Project Narrative The proposed research is relevant to public health as it will significantly advance our understanding of how bariatric surgery leads to resolution of type 2 diabetes. Specifically, this work will define a new molecular pathway that connects the gut, portal vein, and liver and explains how surgical modulation of host and gut microbial metabolites changes how the body metabolizes glucose. This advance will unveil multiple new targets for non-invasive therapies that mimic the anti-diabetic effects of bariatric surgery.

PI_NAMEs: SHEU, ERIC GARLAND (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Ablation;Agonist;Animals;Anti-diabetic Drugs;Bacteria;bariatric surgery;Bariatrics;Bile Acids;Biochemical;Body Composition;Body Weight decreased;Cholic Acids;Chronic;Circulation;Diabetic mouse;diet-induced obesity;Disease remission;Distal;Dose;effective therapy;Enzymes;Feces;feeding;Foundations;Gastrectomy;Germ-Free;glucagon-like peptide 1;Glucose;glucose metabolism;glucose tolerance;Goals;GPBAR1 gene;Grant;Hepatic;Hepatocyte;Human;improved;In Vitro;in vivo;incretin hormone;Individual;Insulin Resistance;insulin secretion;insulin sensitivity;Intestines;knock-down;Knockout Mice;L Cells;Laboratories;Lead;Ligands;Lithocholic Acid;Liver;liver ablation;Long-Term Effects;Mediating;Metabolic;metabolic phenotype;Metabolism;microbial;microbial products;microbiome;Molecular;Mus;Nature;NMR Spectroscopy;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;obesity treatment;operation;Operative Surgical Procedures;Operon;Oral;Pathway interactions;Patients;peripheral blood;Portal vein structure;Production;Property;Public Health;receptor;receptor expression;reconstitution;Research;Resolution;response;Role;side effect;Signal Pathway;Signal Transduction;small hairpin RNA;small molecule;Suggestion;Sulfate;Testing;Therapeutic;Translations;vector;Vitamin D3 Receptor;Weight;Work

PROJECT_TITLE: "A microbiome-dependent bile acid metabolite improves type 2 diabetes."

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: NARRATIVE Solid tumor recurrence is likely driven by slow dividing or quiescent tumor subpopulations in the primary tumor which survive treatment regimens and give rise to secondary tumors. However, we currently lack a basic understanding of molecular features of these populations and, as a result, do not have effective therapeutic strategies to neutralize them. The experiments described in this proposal are directly relevant to public health because they will identify and dissect molecular vulnerabilities that can eliminate tumor subpopulations resistant to conventional therapies.

PI_NAMEs: PADDISON, PATRICK  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acetyltransferase;Adjuvant Therapy;Adopted;Biological Assay;Biological Models;Biology;Brain Neoplasms;Cancer Model;Caring;Cell Cycle;Cells;chemoradiation;Chromatin;Clinic;Clinical;Collection;Communities;Complex;conventional therapy;CRISPR screen;Data;Data Set;Development;epigenetic regulation;Experimental Models;experimental study;Failure;functional genomics;G0 Phase;Gene Expression;gene function;gene network;Genes;Genetic Transcription;Genomics;Glioblastoma;Glioma;Grant;Growth;HTATIP gene;Human;improved;in vivo;Indolent;inhibitor;Knowledge;Lysine;Machine Learning;machine learning method;Malignant Neoplasms;Maps;Mediating;member;Methods;Mitosis;Modeling;Molecular;Neoplasm Metastasis;neoplasm resource;neoplastic cell;neurogenesis;novel;novel therapeutic intervention;Oncogenes;Outcome;Pathway interactions;Patients;Phenotype;Population;prevent;Primary Neoplasm;Public Health;Radiation;Recurrence;Recurrent tumor;Regulation;Reporter;Resistance;Resources;response;Ribosomal DNA;RNA;Role;Sampling;Secondary to;single cell analysis;single cell genomics;single-cell RNA sequencing;Solid;Solid Neoplasm;standard of care;stem-like cell;Stress;System;temozolomide;Testing;therapeutic candidate;therapeutic target;therapeutically effective;therapy resistant;tool;Treatment Protocols;treatment response;tumor;tumor heterogeneity;Xenograft procedure

PROJECT_TITLE: Defining cellular states of quiescence in human brain tumors

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative There are no proven therapies for single ventricle heart failure and the mechanisms involved in the transition to heart failure in this patient population are unknown. Despite the lack of mechanistic studies, phosphodiesterase-5 inhibitors (PDE5i) are widely used in this patient population. The results of this study will provide novel information regarding the transition to heart failure in the SV patient, and investigate the mechanisms through which PDE5i improve mitochondrial function in the failing SV heart.

PI_NAMEs: MIYAMOTO, SHELLEY DEANNE (contact);STAUFFER, BRIAN L;SUCHAROV, CARMEN C

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Acute;Adult;Age;Anatomy;Animal Model;biobank;Blood flow;Cardiac;Cardiac Myocytes;Cardiomyopathies;care outcomes;Childhood;Chronic;Clinical;clinical care;Clinical Trials;Common Ventricle;Complex;Congenital Abnormality;congenital heart abnormality;Data;Deacetylation;Development;Disease;Electron Spin Resonance Spectroscopy;Exercise;exercise capacity;experience;experimental study;Generations;Genetic;Goals;Guidelines;Heart;Heart Diseases;Heart failure;Heart Transplantation;Hematological Disease;honokiol;human tissue;Impairment;improved;improved outcome;Infant;inhibitor;inhibitor therapy;innovation;Institution;Investigation;Literature;Lung;Mediating;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Muscle Cells;Myocardial;Myocardium;National Heart, Lung, and Blood Institute;Neonatal;new therapeutic target;novel;Operative Surgical Procedures;palliation;Palliative Surgery;patient population;Patients;Perioperative;Permeability;Pharmaceutical Preparations;phosphodiesterase V;Physiology;Population;Populations at Risk;Post-Translational Protein Processing;postnatal;pre-clinical;pressure;prospective;Protein Acetylation;Proteome;Publications;Publishing;Rattus;Reactive Oxygen Species;Recommendation;Research;Respiration;response;Risk;Series;Serum;Signal Transduction;sildenafil;Single ventricle congenital heart disease;Sirtuins;Specimen;Spirometry;targeted treatment;Techniques;Tissues;Transplantation;Treatment Failure;Ventricular

PROJECT_TITLE: Targeting Mitochondria in Single Ventricle Heart Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(05)]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative RNA sequencing experiments focused on brain disorders have generated enormous datasets that are being studied to determine which genetic variants are associated with diseases such as schizophrenia, depression, bipolar disorder, and autism spectrum disorder. Most analysis to date has relied on already-known gene isoforms, but recent work has shown that many human gene isoforms are not yet captured in standard gene databases. This proposal will create novel software and databases for better understanding the role of unannotated transcription in the human brain and its potentially important role in serious brain disorders.

PI_NAMEs: SALZBERG, STEVEN L. (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Algorithm Design;autism spectrum disorder;Autopsy;Bipolar Disorder;Brain;Brain Diseases;Brain region;brain tissue;Catalogs;cell type;clinically relevant;Code;Collection;Computer software;Computing Methodologies;Data;Data Set;Databases;Diagnosis;differential expression;Disease;Event;exon skipping;Exons;experimental study;Gene Expression;Genes;Genetic;Genetic Risk;Genetic Transcription;genetic variant;genome wide association study;Genotype-Tissue Expression Project;Human;Human Genome;improved;Learning;Libraries;Major Depressive Disorder;Maps;Measures;Mental Depression;Mental disorders;Methods;neuropsychiatry;novel;Post-Traumatic Stress Disorders;Preparation;Process;Protein Isoforms;Proteins;Quantitative Trait Loci;Regulation;Ribosomal RNA;Risk;RNA;RNA Splicing;Role;Sampling;Schizophrenia;Scientist;Site;Specificity;statistics;System;Techniques;Technology;Tissues;Transcript;Transcription Initiation Site;transcription termination;transcriptome;transcriptome sequencing;Untranslated RNA;Validation;Variant;Weight;Work

PROJECT_TITLE: Comprehensive Human Expressed Sequences in Brain (CHESS-BRAIN) and their roles in neuropsychiatric illness

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]