NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Rare Diseases

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on phenotyping patients with COVID-19 related acute respiratory distress syndrome (CARDS), a devastating critical illness that has caused over 700,000 deaths in the United States alone since 2020 and for which effective therapies are currently limited. Phenotyping CARDS patients to identify those at highest risk of poor outcomes and most likely to benefit from targeted therapies will lay important groundwork for future phenotype-aware trials in COVID-19 and non-COVID-19 related ARDS. This proposal responds to a Critical Challenge laid out by NHLBI’s Strategic Vision to use phenotyping to promote the discovery of druggable targets and enable novel and precise treatments for lung diseases.

PI_NAMEs: ALIPANAH-LECHNER, NARGES  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute Respiratory Distress Syndrome;aspirate;Awareness;Biological;Biological Markers;Biology;biomarker identification;Blood Coagulation Disorders;Blood specimen;Cessation of life;Clinical;Clinical Data;cohort;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19/ARDS;Critical Illness;Data;Data Analytics;Diagnostic;druggable target;effective therapy;Enrollment;epithelial injury;experience;Functional disorder;Future;Gene Expression;Goals;Healthcare Systems;Heterogeneity;high risk;Immune response;improved;Inflammation;Inflammatory;innovation;insight;Institution;interest;Knowledge;Lead;Liquid substance;Lung Diseases;lung injury;Measures;Mentorship;Metabolic acidosis;mortality;National Heart, Lung, and Blood Institute;novel;Outcome;participant enrollment;Patients;peripheral blood;Pharmaceutical Preparations;Phenotype;Plasma;Plasma Proteins;Population;precision medicine;Precision therapeutics;predict clinical outcome;protein biomarkers;Public Health;Randomized, Controlled Trials;Research;response;Role;Shock;Simvastatin;skills;Strategic vision;Syndrome;targeted treatment;Testing;Therapeutic;Time;Tissue-Specific Gene Expression;Trachea;Training;transcriptome sequencing;transcriptomic profiling;transcriptomics;treatment effect;treatment response;United States;Whole Blood;Work

PROJECT_TITLE: Biomarkers and subphenotypes predictive of clinical outcomes in patients with COVID-19 related acute respiratory distress syndrome


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ORTHOPEDICS

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Skeletal muscle stem cell transplantation is emerging as a promising strategy for treating muscle-associated trauma and disorders, but the paucity in their quantity limits their therapeutic potential. The inability to maintain and expand these cells ex vivo further compounds this challenge. This research will develop a geometrically asymmetric culture platform that enable long-term maintenance and expansion of muscle stem cells by directing cellular polarity, division, and fate determination.

PI_NAMEs: HAN, WOOJIN  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Address;Adhesives;adult stem cell;aging population;Apical;Basal lamina;beta catenin;Biochemical;Biocompatible Materials;Biological Assay;Biomechanics;Biophysics;Cachexia;Cell Culture System;Cell division;Cell Polarity;Cell Survival;Cell Therapy;cell type;Cells;cellular engineering;Centrosome;combinatorial;Cues;design;Disease;Dystrophin;Economic Burden;Elasticity;Employment;Engineering;Engraftment;Epidermal Growth Factor Receptor;Ethylenes;Genes;Glycols;Hydrogels;In Vitro;Integrins;Life Cycle Stages;Ligands;Maintenance;mechanical force;mechanical stimulus;Mechanics;mimetics;Mitotic spindle;Muscle;Muscle Fibers;muscle progenitor cell;muscle regeneration;Muscle satellite cell;Muscular Dystrophies;Myogenin;Outcomes Research;Patients;Peptides;Physiological;planar cell polarity;Proliferating;Proteins;receptor;Regenerative Medicine;Regulation;Research;Role;sarcopenia;segregation;self-renewal;Signal Transduction;Skeletal Muscle;socioeconomics;Source;Specific qualifier value;stem cell biology;stem cell division;stem cell expansion;stem cell niche;Stem cell transplant;stem cells;stemness;Stretching;System;Testing;Therapeutic;Transplantation;Trauma;volumetric muscle loss

PROJECT_TITLE: Engineered Asymmetric Hydrogel for Muscle Stem Cell Polarity and Fate Specification

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Hematology;Human Genome;Orphan Drug;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: SCD is a heritable disease, which affects a patient's red blood cells (RBCs) that shorten life expectancy of patients despite treatments. CRISPR-base gene editing presents a promising curative treatment but requires long term monitoring and assessment to ensure treatment efficacy and safety. The central goal of the proposed project is the development of a novel and generalizable platform for rapid assessment of ex vivo CRISPR/Cas9 editing efficiency, using SCD gene therapy as a genetic model.

PI_NAMEs: ARAN, KIANA  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Affect;Alleles;Allogenic;Amino Acid Sequence;base;base editing;Binding;Biological Assay;Blood Transfusion;Cell Separation;Cells;Chromatin;Chromatin Structure;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;Collaborations;Complex;Consumption;cost;cost effective;CRISPR/Cas technology;curative treatments;design;detection limit;Development;Disease;DNA;DNA analysis;early screening;Electronics;Employment;Engraftment;Ensure;Enzymes;Erythrocytes;Evaluation;Fetal Hemoglobin;flexibility;Flow Cytometry;Gases;gene therapy;Genes;Genetic Models;genome-wide;Genomic DNA;Genomics;Glutamates;Goals;graft vs host disease;graphene;Guide RNA;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobinopathies;Heritability;high risk;Human;Human Genome;Immunologics;improved;In Vitro;in vivo;Infection;Infection prevention;Infertility;Journals;Libraries;Life Expectancy;Membrane Proteins;Mendelian disorder;Methods;Missense Mutation;Monitor;Morphologic artifacts;Mutation;nanoelectronics;Nature;novel;nuclease;Nucleotides;off-target site;Optics;Organ;Orthologous Gene;Pathogenicity;Patients;Physiological;Point Mutation;Polymorphism Analysis;Population;Preparation;Prevalence;Process;Production;Publishing;Quality Control;Quality of life;Resources;RNA library;Safety;Sampling;scale up;screening;sensor;Sickle Cell Anemia;Single Nucleotide Polymorphism;Source;success;System;Technology;Testing;Therapeutic;Time;Tissues;tool;transcription factor;Transistors;Transplantation;Treatment Efficacy;Valine;Vendor

PROJECT_TITLE: CRISPR-based transistors for high throughput multiplexed monitoring of CRISPR-based editing efficiency for Sickle cell disease

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Clinicians rely on structural (optical coherence tomography) and functional (visual field) tests to diagnose and monitor glaucoma. The proposed research will build upon previous work to develop a method that combines structural and functional information, and topographically assesses agreement between structure and function in an automated and objective fashion. This method should provide a better understanding of the structure- function relationship, improve the diagnosis and monitoring of glaucoma, and make available an objective tool for structure-function endpoints useful for clinical trials in glaucoma.

PI_NAMEs: TSAMIS, EMMANOUIL  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Acceleration;Affect;Agreement;Algorithmic Software;Algorithms;automated assessment;Blindness;career development;Caring;Characteristics;Clinic;Clinical;Clinical Trials;cost;Data;Data Science;Data Set;Databases;design;Detection;Development;Diagnosis;Disease;Early identification;Equilibrium;Evaluation;Event;Eye;field study;Floor;Frequencies;Glaucoma;Goals;improved;independency;indexing;Inferior;Investigation;Literature;macula;Manufacturer;Maps;Measures;Mentors;Mentorship;Methods;Modality;Monitor;Nature;neuroprotection;optic nerve disorder;Optical Coherence Tomography;Participant;Pathway interactions;Patients;Pattern;Performance;Phase;Phenotype;Population Sizes;Probability;programs;Protocols documentation;Reference Standards;Reporting;Research;Retinal Ganglion Cells;retinal nerve fiber layer;Scanning;skills;Standardization;statistics;Structure;Structure-Activity Relationship;study population;Techniques;Testing;Thick;Time;tool;Training;translational potential;trend;Validation;Visit;Visual Fields;visual optics;Work

PROJECT_TITLE: Development, validation and assessment of an automated, topographic structure-function approach to the detection of glaucoma and its progression

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Violence Against Women;Violence Research;Women's Health Research

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: Narrative - no change from parent grant Physical trauma as an outcome of intimate partner violence (IPV) impacts an estimated 10 million people in the United States each year, with up to 90% of women exposed to IPV reporting episodes of abuse with head trauma. Women exposed to IPV are at a high-risk for developing mental illness and impaired cognitive function, which seems to be compounded in those with exposure to head trauma. This proposal aims to investigate the impact exposure to head trauma in IPV has on cognitive, psychological, and neural processes.

PI_NAMEs: ESOPENKO, CARRIE LYNN (contact);HILLARY, FRANK GERARD;LIN, ALEXANDER PETER;WILDE, ELISABETH A

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acceleration;Administrative Supplement;Affect;Aggressive behavior;Anoxia;Anxiety;Behavioral;Blunt Trauma;Brain;Brain Concussion;Chronic;Clinical;Cognitive;cognitive function;Cohort Studies;Collaborations;Contusions;Craniocerebral Trauma;Data;Deceleration;Development;experience;Exposure to;Frequencies;Genetic;Height;high risk;Hypoxia;Impaired cognition;Injury;Interview;intimate partner violence;life span;member;Mental Depression;Mental disorders;Meta-Analysis;Military Personnel;neural;neuroimaging;Neuropsychology;Outcome;parent grant;Patient-Centered Care;Persons;Population;Post-Traumatic Stress Disorders;Process;psychologic;psychological outcomes;Public Health;Recording of previous events;Reporting;Research;Risk;Role;sexual violence;Site;Sports;Structure;Subgroup;symptom cluster;symptomatology;Techniques;Trauma;Traumatic Brain Injury;United States;Violence;Woman;Work;working group

PROJECT_TITLE: SGM Administrative Supplement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-S]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Clinical Research;Comparative Effectiveness Research;Health Services;Infectious Diseases;Kidney Disease

ORG_CITY: OVERLAND PARK

ORG_NAME: FLOWPOINT MEDICAL INC

ORG_STATE: KS

PHR: PROJECT NARRATIVE Ensuring dependable and safe access to a patient's bloodstream is critical for successful hemodialysis. Using a cutting-edge implantable vascular access device, we will address this unmet medical need, enhance the quality of life for end-stage kidney disease patients, and reduce system-wide healthcare costs.

PI_NAMEs: AZELOGLU, EVREN U.;BOBE, JASON  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: 3D Print;Address;Adoption;Adverse event;American;Animal Experiments;Animals;Arteriovenous fistula;Biocompatible Materials;Blood;Blood Circulation;Blood Vessels;Budgets;Cannulations;Caring;Cause of Death;Certification;Clinical;Clinical Management;Clinical Trials;Coagulation Process;cost;cost effectiveness;design;Devices;Dialysis patients;Dialysis procedure;Dimensions;Distress;Elasticity;End stage renal failure;Engineering;Ensure;Event;Excision;Failure;FDA approved;Financial Hardship;first-in-human;Fistula;Focal Infection;Future;Geometry;good laboratory practice;Health Care Costs;Healthcare Systems;Hematoma;Hemodialysis;Hemorrhage;Hemostatic function;Home;Home Hemodialysis;Immune response;Implant;implantable device;Improve Access;improved;in silico;in vivo;Infection;infection risk;Inflammation;Inflammatory;injured;innovation;Legal patent;Life;Life Expectancy;manufacturability;manufacture;Measures;Medical;Medicare;Methods;Modeling;Morbidity - disease rate;mortality;Muscle;Needles;Nephrology;Outcome;pain reduction;Patient-Focused Outcomes;Patients;Performance;Phase;Population;Positioning Attribute;pre-clinical;preclinical study;pressure;Procedures;Process;Production;Public Health;Quality Control;Quality of life;Recording of previous events;Risk;risk minimization;Safety;seal;Serious Adverse Event;Sheep;sheep model;simulation;Site;Small Business Innovation Research Grant;Specific qualifier value;standard of care;Structure;subcutaneous;Surface;System;Techniques;Technology;Testing;Time;Tissues;Titanium;United States National Institutes of Health;Weight;Withdrawal

PROJECT_TITLE: Self-sealing needle guide system for reliable hemodialysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-W (12)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE An effective HIV vaccine will be dependent on stimulating a protective immune response in individuals at greatest risk for HIV infection. This project will determine the features of B cells that can respond to an HIV vaccine and how their characteristics and mobilization may differ in diverse populations of high-risk individuals. The findings will inform the development of future HIV vaccine strategies.

PI_NAMEs: KOBIE, JAMES J (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: Address;Affinity;Antibodies;Antibody Response;Antigens;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Binding Sites;Cell Compartmentation;Cells;Characteristics;Chlamydia trachomatis;Clinical Trials;cohort;Complement;cross reactivity;Cross-Sectional Studies;Dengue;design;Development;efficacy trial;Engineering;Exposure to;Funding;Future;Genetic;Germ Lines;Heterogeneity;high risk;high risk population;HIV;HIV Envelope Protein gp120;HIV Infections;HIV Seronegativity;HIV vaccine;HIV Vaccine Trials Network;Immune;Immune response;Immunization;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunoglobulin Somatic Hypermutation;Immunologics;imprint;Individual;Infection;Influenza;insight;Mediating;Memory;Memory B-Lymphocyte;microbiota;Modeling;Molecular;Monoclonal Antibodies;neutralizing antibody;Outcome;Participant;Pathway interactions;peripheral blood;Phenotype;Plasma;Population;Population Heterogeneity;pre-exposure prophylaxis;Preventive vaccine;prospective;Regulation;Resolution;response;Risk;Sampling;Sexually Transmitted Diseases;South Africa;systemic inflammatory response;United States National Institutes of Health;Vaccination;vaccine efficacy;vaccine response;vaccine strategy;Vaccines;Virus

PROJECT_TITLE: Origins and dynamics of HIV gp120 specific B cell memory in HIV negative high-risk individuals

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation;Stroke

ORG_CITY: PITTSBURGH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: This project seeks to increase the functional impact of established aphasia treatment by combining the benefits of complementary learning approaches through adaptive timing models. Successful outcomes will show that adaptive computer-based treatments provide a novel way to produce large, durable, and generalizable improvements and will develop the next generation of aphasia-specific timing and learning models. This study has high potential clinical impact as treatment paradigms from this study are clinically feasible and implementable in the near term.

PI_NAMEs: EVANS, WILLIAM STREICHER (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: adaptive learning;Address;Affect;Aftercare;Algorithms;Anomia;Aphasia;aphasia rehabilitation;Brain Injuries;Clinical;clinical practice;Clinical Trials;Combined Modality Therapy;Complex;Computer software;Computers;Data;effective intervention;Equilibrium;Frustration;Future;improved;Individual;innovation;Language Disorders;Learning;Memory;model building;Modeling;Names;next generation;novel;open source;Outcome;Patients;Performance;personalized medicine;Persons;Quality of life;Research;Retrieval;Schedule;Speech;Speed;standard care;Stroke;System;Testing;theories;Time;Training;treatment research

PROJECT_TITLE: Reintegration Supplement


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: CHICAGO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Patients have cardiac outflow tract defects frequently requiring medical intervention. The affected cardiac outflow tract structures include cardiac septum and semilunar valves derive from embryonic progenitor cells in neural crest tissue and endocardium. This research project will determine the molecular and cellular mechanisms downstream of the 22q11.2 deleted region that regulate the functions of these progenitor cells to form the cardiac outflow tract.

PI_NAMEs: MORROW, BERNICE E;ZHOU, BIN  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: 22q11;22q11.2;3-Dimensional;Affect;bicuspid aortic valve;Biological Assay;Cardiac;cardiogenesis;Cell Communication;Cell Lineage;cell motility;Cells;Clinical;Code;congenital heart abnormality;connective tissue growth factor;Defect;Development;Developmental Biology;DiGeorge Syndrome;Disease;Distal;Early identification;Embryo;embryonic stem cell;Endocardium;Endothelin-1;Ensure;experimental study;gene interaction;Genes;Genetic;genetic signature;genetic variant;Heart;Heart Septum;Histology;Human;Immunofluorescence Immunologic;In Situ Hybridization;in vivo;Intervention;Knowledge;Live Birth;malformation;Medical;Mesenchymal;Modeling;Molecular;Morphogenesis;mouse model;Mus;mutant;Mutation;Neural Crest;Neural Crest Cell;Neural tube;Neurophysiology - biologic function;Newborn Infant;NOTCH1 gene;Outcome;Patients;Pattern;Persistent Truncus Arteriosus;Phenotype;Population;Positioning Attribute;Prevalence;Process;programs;Proteins;Pulmonary Circulation;reconstruction;Research Project Grants;restoration;Role;semilunar valve;Signal Transduction;single-cell RNA sequencing;stem cell function;stem cells;Structural defect;Structure;Testing;Tetralogy of Fallot;Tissues;Validation;Ventricular Septal Defects;Ventricular septum

PROJECT_TITLE: Molecular and cellular mechanisms in cardiac outflow tract formation and defects

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cardiovascular;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Neurosciences;Pediatric

ORG_CITY: ANN ARBOR

ORG_NAME: MITOVATION, INC.

ORG_STATE: MI

PHR: U44 NS125160 - Narrative: Project Narrative: Interrupted blood flow to the brain during cardiac arrest initiates progressive brain injury in resuscitated infants, and this neurologic injury is a significant contributor to the death and disability. We have discovered that treatment with specific wavelengths of infrared light, applied non-invasively following resuscitation, substantially reduces the production of free radicals and brain damage. We have developed a device capable of providing this therapy to children up to 1 year old and we propose to produce and validate the clinical device, then conduct a small clinical trial to assess the impact of treatment on neurologic function in infant cardiac arrest patients.

PI_NAMEs: HUETTEMANN, MAIK ;SANDERSON, THOMAS HUDSON;WADDELL, WILEY THOMAS (contact)

PROGRAM_OFFICER_NAME: WU, GUANGYING

PROJECT_TERMS: 1 year old;Address;Blood flow;Brain;Brain Injuries;Cardiopulmonary Resuscitation;Cessation of life;Child;Childhood;Circulation;Clinical;Clinical Engineering;Clinical Trials;cytochrome c oxidase;Data;Development;Device or Instrument Development;Devices;disability;Dose;Free Radicals;Goals;Health;Heart Arrest;Hospitals;Infant;Interruption;Intervention;Ischemia;Light;Medical Device;Medical emergency;Methods;Mitochondria;Molecular;multidisciplinary;natural hypothermia;Nervous System Physiology;Nervous System Trauma;neuroprotection;novel;out-of-hospital cardiac arrest;Oxidases;patient population;Patients;Phase;porcine model;Production;Reperfusion Injury;Reperfusion Therapy;Resources;Respiration;Resuscitation;Rodent Model;Safety;standard care;System;Testing;Therapeutic;Therapeutic Uses;Time;Validation

PROJECT_TITLE: Development and Testing of LUCID: A Therapeutic Device for Brain Injury Following Infant Cardiac Arrest


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative This research addresses the need to eradicate sexual harassment and racially motivated mistreatment of graduate students and post-doctoral fellows in biomedical research training programs so that women and racial/ethnic minoritized students can thrive and contribute to scientific discovery. We examine the role of mentors’ power on their proclivity to sexually and racially harass and exacerbated by power-based structural elements of the training environment, and we develop a comprehensive intervention to dismantle those forces.

PI_NAMEs: KIMBLE-HILL, ANN CAROL;STOCKDALE, MARGARET S (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Accountability;Address;Affect;Affective;Antidotes;Authorship;Behavior;Behavioral;Behavioral Sciences;Biomedical Research;Brassicaceae;career;Characteristics;Climate;climate change;Cognition;cohort;Collaborations;combat;Data;Demographic Factors;Demography;design;Development;Elements;emotional distress;Emotions;Empathy;Environment;Equity;ethnic minority;Exclusion;experience;Faculty;Fellowship;Female;Gender;Goals;graduate student;Grant;harassment;improved;In Situ;Incidence;Indiana;Individual;Inequity;insight;Institution;Intervention;Knowledge;Lead;Licensing;Link;maltreatment;Manuscripts;marginalization;Measures;Medical;Mentors;Mentorship;Methodology;microaggression;Minority;minority student;minority trainee;Morals;Nature;Organizational Change;Outcome;Pathway interactions;Pattern;Personality Character;Persons;perspective taking;Postdoctoral Fellow;prevent;Professional Practice;programs;Race;racial minority;Randomized;Records;Reporting;Research;Research Training;response;Role;Sampling;Science;Scientific Advances and Accomplishments;sex;Sexual Harassment;social exclusion;Students;success;Surveys;Talents;Testing;theories;Training;Training Programs;United States National Institutes of Health;White Women;Woman;workforce needs

PROJECT_TITLE: Indiana CARES (Creating Accountability and Building Relationships to Eradicate Sex Harassment)


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative not required, refer to: NOT-GM-22-017: Notice of Special Interest (NOSI): Administrative Supplements for Equipment Purchases for Select NIGMS-Funded Awards (nih.gov)

PI_NAMEs: LEE, ROBIN E. C. (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Administrative Supplement;Award;Cell Fate Control;Equipment;equipment acquisition;Funding;interest;National Institute of General Medical Sciences;Signal Transduction

PROJECT_TITLE: Equipment Supplement for 5R35GM119462: Deciphering dynamic signals in control of cell fate decisions


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Services;Patient Safety

ORG_CITY: Denver

ORG_NAME: DENVER RESEARCH INSTITUTE

ORG_STATE: CO

PHR: Project Narrative This proposal aims to investigate and optimize multidisciplinary preoperative surgical decision-making discussions for older adults. The proposal's results will introduce a new model for communication between older adults, their caregiver(s) and healthcare professionals to make informed, patient-centric decisions about high- risk operations. The proposed project and education plan will allow the candidate to become an independent investigator with a career goal of redesigning surgical decision-making for high-risk older adults.

PI_NAMEs: JONES, TERESA S (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Award;cancer therapy;career;career development;Caregivers;Caring;Communication;Complex;Conflict (Psychology);Consent;cost;Data;Decision Making;design;education planning;Ensure;experience;Family;Functional impairment;Goals;Health;Health Care Surveys;Health Personnel;Health Professional;Healthcare;high risk;Impaired cognition;implementation barriers;improved;Inpatients;Institution;Interview;K-Series Research Career Programs;Knowledge;Life;Malignant Neoplasms;Measures;Medical;Medical Care Team;Medical center;medical specialties;meetings;member;Mentors;Methods;Modeling;mortality;multidisciplinary;novel;older adult;operation;Operative Surgical Procedures;Outcome;patient engagement;Patient Participation;Patients;Pattern;Perioperative;Pilot Projects;Procedures;Process;provider communication;Qualitative Methods;Reporting;Research Personnel;Self Efficacy;shared decision making;Standardization;Structure;Surgical Management;surgical risk;symposium;Testing;Time;tumor

PROJECT_TITLE: Multidisciplinary Surgical Decision Making for Older, High Risk Patients


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Nanotechnology;Rare Diseases;Transplantation;Wound Healing and Care

ORG_CITY: MILWAUKEE

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: Project Narrative: Osteo-odonto keratoprosthesis (OOKP) or Tooth-in-Eye surgery is an effective treatment for end-stage corneal diseases. The success rate in OOKP procedure is high, however, it is a very aggressive surgery in which a patient's tooth along with its adjacent tissue is removed to make a special prosthesis (known as osteo-odonto- lamina) for the procedure. In this proposal, we make a synthetic prosthesis to mimic the osteo-odonto-lamina to eliminate the aggressive part of the surgery.

PI_NAMEs: TAYEBI, LOBAT  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3D Print;Accountability;Adhesions;Adhesives;Alkalies;Alloys;aqueous;Autologous;Autologous Transplantation;Biocompatible Coated Materials;Biologic Characteristic;Biological;Biological Assay;biomaterial compatibility;Blood Vessels;Bullous Pemphigoid;Cell Adhesion;Cell Proliferation;Cell Survival;Cell-Matrix Junction;Cells;Characteristics;Chemical Burns;Coculture Techniques;Collagen;Complex;Consumption;Cornea;Corneal Diseases;Corneal Injury;Cultured Cells;density;Dental;design;Dryness;effective therapy;Endothelial Cells;Ensure;Environment;experimental study;Exposure to;Eye;Failure;Fibroblasts;Freeze Drying;Gel;graft failure;Growth;Harvest;Human;hydrophilicity;Hypoxia Inducible Factor;Immersion;Implant;improved;In Vitro;inhibitor;Keratoplasty;Legal patent;Length;matrigel;Measurement;Mechanics;Methods;Microscopic;Modification;Morphology;multidisciplinary;nanoparticle;novel;Operative Surgical Procedures;Ophthalmologic Surgical Procedures;Ophthalmology;Optics;Oral cavity;Oxides;parent project;Parents;Patients;Penetration;Pharmaceutical Preparations;Polymethyl Methacrylate;Porosity;Procedures;Process;Procollagen-Proline Dioxygenase;Prosthesis;Roentgen Rays;Sampling;Scanning Electron Microscopy;Serum Albumin;Services;severe injury;Signaling Molecule;Silicon Dioxide;Sodium;soft tissue;Solid;Specific qualifier value;Spectroscopy, Fourier Transform Infrared;Spectrum Analysis;Stevens-Johnson Syndrome;Structure;success;Surface;surfactant;Surgeon;Suspensions;Techniques;Testing;Time;Tissue Harvesting;Tissues;Titanium;Tooth structure;Trachoma;Transmission Electron Microscopy;Tube;Tubular formation;Umbilical vein;Vascularization;Water;X ray diffraction analysis;X ray spectroscopy

PROJECT_TITLE: Synthetic osteo-odonto-keratoprosthesis (OOKP, Tooth-in-Eye surgery)


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Arthritis;Bioengineering;Biotechnology;Osteoarthritis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

PHR: Treating defects in cartilage and osteochondral tissue remains a formidable clinical problem that eventually leads to osteoarthritis, a debilitating disease. To address this challenge, this project will develop a tissue engineering solution that utilizes bioinspired 3D printing and biomimetic hydrogels to guide stem cell differentiation, promote tissue regeneration and support integrative repair, while protecting the surrounding tissue from further degeneration.

PI_NAMEs: BRYANT, STEPHANIE J (contact)

PROJECT_TERMS: 3D Print;Address;Animals;articular cartilage;Biomimetics;bone;Cartilage;cell motility;Cell Separation;Cementation;Clinical;Cues;Defect;Degenerative polyarthritis;design;Disease;DsRed;effectiveness evaluation;Engineering;Environment;Family suidae;Funding;Goals;Health;Hydrogels;implantation;In Vitro;in vivo;in vivo monitoring;Joints;Label;Lesion;Longitudinal Studies;mechanical properties;Mechanics;mechanotransduction;Mesenchymal Stem Cells;mimetics;Modeling;Monitor;Natural regeneration;Nutrient;osteochondral tissue;Pathway interactions;pre-clinical;Rattus;regenerative approach;repaired;stem cell differentiation;stem cell fate;stem cells;Structure;subchondral bone;Surface;Testing;Tissue Engineering;tissue regeneration;Tissues;Translating;Weight-Bearing state

PROJECT_TITLE: An Engineered Tidemark for Osteochondral Tissue Engineering

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Biotechnology;Genetics;Immunization

ORG_CITY: Branford

ORG_NAME: ABBRATECH, INC.

ORG_STATE: CT

PHR: Narrative This proposal aims to develop a platform for identifying and validating specific types of antibodies, with a focus on addressing challenges in a particular area of disease research. The first phase of the project will validate existing antibodies using standard methods and produce new ones on the same sites as proof of concept. The second Phase involves increasing the production of new isoform-specific antibodies and ensuring they are effective and reliable for broader use, which could significantly change the approach to diagnosing and treating diseases related to this specific area of protein research.

PI_NAMEs: WEINER, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Adoption;Affinity;Alternative Splicing;Amino Acids;anti-cancer research;Antibodies;antibody libraries;Area;Bacteriophages;Benchmarking;Binding;Cell Line;Collaborations;commercialization;Communities;Complex;Development;Diagnosis;Disease;Early identification;Education;Effectiveness;Ensure;Evaluation;Flow Cytometry;Future;G-Protein-Coupled Receptors;Genetic Polymorphism;Goals;In Vitro;in vivo;innovation;Letters;Libraries;Malignant - descriptor;manufacturing scale-up;Marketing;Measures;Methods;Monoclonal Antibodies;Mus;neoantigens;neoplastic cell;novel;Oncology;Oryctolagus cuniculus;overexpression;Phage Display;Phase;practical application;Process;Production;Protein Isoforms;Protein Splicing;Proteins;Quality Control;real world application;Recombinant Antibody;Research;RNA Splicing;scale up;screening;Services;Site;success;System;Techniques;Technology;Testing;Therapeutic antibodies;Trust;tumor progression;Validation;Variant;vector;Vision;Western Blotting;Work;Yeasts

PROJECT_TITLE: DIRECTED DISCOVERY AND VALIDATION OF ANTI-SPLICE-JUNCTION SITE Abs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (15)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative This project will test a multi-level intervention to increase physical activity among public housing residents. If successful, this intervention can be generalized to other urban living situations.

PI_NAMEs: QUINTILIANI, LISA M. (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Accelerometer;active lifestyle;Address;Advocate;Attention;Attitude;Behavior;behavior change;Boston;Characteristics;Chronic Disease;cohort;Community Health Aides;comparison control;comparison intervention;Complex;Consolidated Framework for Implementation Research;Control Groups;design;Development;Disease Marker;efficacy testing;eHealth;Environment;environmental change;environmental intervention;Environmental Risk Factor;Evaluation;exercise intervention;Financial Hardship;follow-up;Fostering;future implementation;group intervention;Guidelines;Housing;improved;Individual;informant;Infrastructure;Institute of Medicine (U.S.);Intervention;intervention effect;Intervention Studies;Interview;Literature;Low income;Low Income Population;Measurement;Measures;Mediation;Mediator;meetings;Moderate Exercise;Motivation;Neighborhoods;Obesity;Participant;Persons;Physical activity;Pilot Projects;Population;Prevalence;programs;prospective;Public Health;Public Housing;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Resources;Science;sedentary activity;sedentary lifestyle;Self Efficacy;Sleep;social;social cohesion;social norm;Stress;Sum;Telephone;Testing;Treatment Efficacy;walkability

PROJECT_TITLE: Multilevel Physical Activity Intervention for Low Income Public Housing Residents

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: SEATTLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Molecular communication across cell types is central to life—communication between cell types in a human organ is critical to normal function, and microbe-host or microbe-microbe communication drives microbial ecosystems. This proposal will study signaling between human immune cells and fibroblasts and signaling between microbes relevant for human health (e.g., commensal and pathogenic bacteria and fungi). We will develop a suite of microfluidic tools to broaden the scope of mechanistic questions that can be addressed, ultimately enabling the development of therapies to target dysfunctional signaling and inflammation in human disease.

PI_NAMEs: THEBERGE, ASHLEIGH BROOKS (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Affect;Area;B-Lymphocytes;Bacteria;Biological Assay;Biological Process;Biomedical Engineering;Biomimetics;Blood capillaries;cell type;Cells;Chemical Stimulation;Chemicals;commensal bacteria;commensal microbes;Communication;Complex;cost effective;Development;Disease;Ecosystem;Engineering;eosinophil;experimental study;Fiber;Fibroblasts;fungus;Future;Health;Home;Human;human disease;Immune;Immune response;Inflammation;Inflammatory;innovation;Investigation;Life;Mass Fragmentography;Mediating;Methods;Microbe;microbial;microbial community;Microfluidics;Molecular;monocyte;neutrophil;novel;novel strategies;Organ;paracrine;Paracrine Communication;pathogen;pathogenic bacteria;Phase;Positioning Attribute;Production;Role;sample collection;Sampling;Signal Transduction;Signaling Molecule;Signaling Protein;small molecule;Solid;System;therapy development;Time;tool;Translating;user-friendly;Vocabulary;volatile organic compound;Volatilization;Work

PROJECT_TITLE: Deciphering the role of chemical signals in inflammation with open microfluidic functional assays - Bouker Diversity Supplement

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Childhood Obesity;Neurosciences;Nutrition;Obesity;Pediatric

ORG_CITY: LARAMIE

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: Childhood obesity is spiraling out of control and leads to metabolic disease and premature death later in life. Understanding the impact of early life overnutrition is critically important, and the hypothalamus is a key brain region in metabolic regulation. This proposal addresses the mechanisms by which developmental overnutrition affects the function of neural circuits essential for energy balance with particular effort placed on the interplay between metabolic processing and time of day.

PI_NAMEs: ROBERTS, BRANDON L (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Address;adult obesity;Affect;Attention;Behavior;Biology;Body System;Brain;Brain region;Cardiovascular Diseases;Cell Physiology;Cells;Centers of Research Excellence;Cessation of life;Child;Chronic;Development;diet-induced obesity;Eating;Electrophysiology (science);Endocrine;energy balance;experimental study;Gene Expression;Hormones;Hunger;Hypothalamic structure;Intervention;Investigation;Knowledge;Leptin;Leptin resistance;Life;Metabolic;Metabolic Diseases;Metabolism;neural circuit;Neurons;neuropeptide Y;neurophysiology;Neurophysiology - biologic function;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity in children;Outcome;Overnutrition;Overweight;Physiology;Population;postnatal;premature;Process;Regulation;response;Sensory;Signal Transduction;Slice;Stroke;Structure of nucleus infundibularis hypothalami;Synapses;Time;Wyoming

PROJECT_TITLE: Impact of early overnutrition on leptin signaling in hypothalamic neuropeptide Y neurons


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Patient Safety;Pediatric;Precision Medicine

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Broadly, the goal of the proposed project is to understand associations between specific therapeutic elements that are common in evidence-based youth psychotherapies (e.g., exposure; cognitive reappraisal) and symptom change in the context of modular youth psychotherapy, a well-tested flexible approach to psychotherapy. The project may enhance our understanding of which therapeutic elements are associated with better and worse outcomes, what factors (such as client clinical and demographic characteristics, and timing of module delivery) moderate these associations, and how findings from statistical models can be used to inform data-driven recommendations regarding which therapeutic elements to use when, tailored to fit young clients’ demographic and clinical characteristics. The findings of this project may inform decision-making in modular youth psychotherapies, potentially enhancing the efficiency and effectiveness of treatment.

PI_NAMEs: VENTURO-CONERLY, KATHERINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Age;Agreement;Anxiety;archived data;career;Characteristics;Child;Client;Clinical;clinical decision-making;clinical development;clinical practice;Clinical Trials;Code;Cognitive;cognitive reappraisal;Complex;conduct problem;Consultations;Data;Data Aggregation;data-driven model;Decision Making;Disease;Effectiveness;Elements;evidence base;Family;Family Characteristics;flexibility;Future;Goals;Growth;improved;improved outcome;Individual;individualized medicine;Intervention;Interview;Judgment;Length;Literature;Mental Depression;Mental Health;Mental Health Services;Meta-Analysis;Methods;Modeling;National Institute of Mental Health;Outcome;Patients;personalized medicine;Persons;predictive modeling;Provider;Psychotherapy;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Sampling;satisfaction;Selection for Treatments;Series;Standardization;statistical learning;Statistical Models;Structure;Symptoms;systematic review;Testing;Therapeutic;tool;Trauma;treatment as usual;Treatment Effectiveness;Treatment outcome;virtual;Work;Youth

PROJECT_TITLE: Enhancing Clinical Decision-Making in Modular Youth Psychotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ORG_CITY: NEW HAVEN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE The World Health Organization estimates that in 2022 almost 40 million people worldwide are infected with HIV. There continues to be a significant need for new drugs and drug combinations to combat this disease and a great deal of effort to develop drugs against HIV has centered around the molecular target, HIV reverse transcriptase (RT). The studies outlined in this proposal will combine mechanistic studies with computational and structural guidance to design more effective therapies that have improved therapeutic properties.

PI_NAMEs: ANDERSON, KAREN S. (contact)

PROGRAM_OFFICER_NAME: PTAK, ROGER

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS therapy;antiretroviral therapy;Capsid;Cell Death;cell killing;Cells;clinically relevant;combat;Combined Modality Therapy;design;Development;Dimerization;Disease;Dose;Drug Combinations;Drug resistance;Drug Targeting;effective therapy;Etiology;Family;Formulation;Genome;HIV;HIV drug resistance;HIV Protease;improved;Inflammasome;inhibitor;lead optimization;Mediating;member;Molecular Target;mouse model;New Agents;novel;novel lead compound;novel strategies;novel therapeutics;nucleoside inhibitor;Pathway interactions;Patient Compliance;Persons;Pharmaceutical Preparations;pharmacologic;pre-clinical;pre-exposure prophylaxis;premature;Property;prophylactic;Regimen;Resistance profile;resistant strain;RNA;RNA-Directed DNA Polymerase;Safety;side effect;Structure;synergism;Therapeutic;Variant;Viral;Virus Replication;World Health Organization

PROJECT_TITLE: Mechanism and Inhibition of HIV Reverse Transcriptase

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Machine Learning and Artificial Intelligence

ORG_CITY: MINNEAPOLIS

ORG_NAME: OBJECTIVE BIOTECHNOLOGY, INC.

ORG_STATE: MN

PHR: PROJECT NARRATIVE In this proposal, Objective Biotechnology seeks to develop a commercial-grade automated microinjection system, building on an extensively validated system developed by the company’s founders at the University of Minnesota via an R21 grant. This technology will support microinjection investigations for transgenesis, mutagenesis, cell labeling, small molecule screening, cryopreservation, and in vitro fertilization across many different organisms. Our automated microinjection system will make these techniques more accessible, reduce costs, and dramatically increase the scale at which such experiments can be carried out, broadly accelerating discovery related to human health and disease in animal research models, and thus this proposal is relevant to most NIH Institutes.

PI_NAMEs: ALEGRIA, ANDREW D (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Acceleration;Address;Affect;Agar;Algorithms;Animal Experimentation;Applications Grants;Basic Science;biological research;Biology;Biomedical Research;Biotechnology;Caenorhabditis elegans;Cells;Clinical Research;Collection;Commercial grade;commercialization;Computer Vision Systems;Consumption;cost;CRISPR/Cas technology;Cryopreservation;Culture Media;Data;design;Detection;Devices;Disease;DNA;Double-Stranded RNA;Drosophila genus;Drosophila melanogaster;Dyes;efficacy evaluation;egg;Embryo;Environment;Evaluation;experience;experimental study;Failure;Farm;Feedback;Fertilization in Vitro;fly;Gene Transfer Techniques;Genetic;Genomics;Goals;Grant;Health;Hour;Human;improved;Individual;Injections;innovation;instrumentation;Intervention;Investigation;Label;Laboratories;Laboratory Research;Legal patent;Location;Machine Learning;machine learning algorithm;machine learning model;machine vision;Manuals;Mediating;Microbiology;Microinjections;Microscopic;Minnesota;model organism;Modeling;Monitor;multidisciplinary;Mus;Mutagenesis;Mutation;Needles;Neurosciences;operation;Organism;Outcome;Performance;Phase;Plasmids;Procedures;Process;Protocols documentation;prototype;Research;Resources;Robot;Robotics;screening;Site;skills;Small Business Innovation Research Grant;small molecule;Speed;success;System;Techniques;Technology;Testing;Time;tool;Training;Transgenes;Transgenic Organisms;Transplantation;United States National Institutes of Health;Universities;Viscosity;Zebrafish

PROJECT_TITLE: Machine vision guided robotics for automated microinjections into fruit fly embryos


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Immunotherapy;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: HAYWARD

ORG_NAME: PLANET BIOTECHNOLOGY, INC.

PHR: Gonorrhea is the second most common bacterial STI and affects over 87 million people annually, globally. The emergence of multidrug-resistant gonococcal strains worldwide has severely limited treatment options. Safe and effective therapeutics against gonorrhea are urgently needed. Here, we will develop and evaluate a bispecific antibody fusion protein intended to provide broad protection against both PorB1A and PorB1B Neisseria gonorrhoeae strains.

PI_NAMEs: RAM, SANJAY ;WYCOFF, KEITH  (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Acceleration;Affect;Alleles;Antibiotics;Attenuated;bactericide;Binding;Biological Assay;Bispecific Antibodies;Blood Circulation;C-terminal;Ceftriaxone;Cell surface;Cells;Chimeric Proteins;Chinese Hamster;Chinese Hamster Ovary Cell;Clinical;comparative efficacy;Complement;complement 4b-binding protein;Complement component C7;Complement Factor H;Complement Inactivators;Complement Membrane Attack Complex;cost;Cytidine Monophosphate N-Acetylneuraminic Acid;Data;design;Development;Disease;Doxycycline;drug resistance development;Ectopic Pregnancy;efficacy testing;Ensure;Environment;Epitopes;Etiology;Failure;Freeze Drying;Gonorrhea;Head;Human;IgG3;Immune Evasion;In Vitro;in vivo;Inbred BALB C Mice;Individual;Infection;Infertility;inhibitor;Knockout Mice;Lead;lead candidate;Licensing;Light;lipooligosaccharide;low and middle-income countries;major outer membrane protein;marginalized population;Membrane;membrane assembly;Minority;Modeling;Monoclonal Antibodies;Multi-Drug Resistance;Mus;Mutation;N-terminal;Neisseria gonorrhoeae;novel;Ovary;parenteral administration;Pelvic Inflammatory Disease;Persons;Pharmaceutical Preparations;Phase;preclinical development;prevent;Preventive;Preventive measure;Process;Production;Prophylactic treatment;Proteins;Recommendation;recruit;Reporting;Resistance;Sialic Acids;sialylation;Sialyltransferases;Small Business Technology Transfer Research;socioeconomic disadvantage;socioeconomics;Surface;Sushi Domain;System;Tail;Testing;Therapeutic;therapeutically effective;Topical application;Transgenic Mice;Transgenic Organisms;Vaccines;Vagina;Vaginal Ring;VDAC1 gene;Virulence;Virulence Factors;Wild Type Mouse;Woman;Work

PROJECT_TITLE: Bispecific antibody for topical administration to prevent gonorrhea

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (12)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

PHR: Rocky Mountain spotted fever (RMSF), caused by the intracellular bacterium Rickettsia rickettsii, is clinically similar to severe viral hemorrhagic fevers and is characterized by high fever, severe headache and maculopapular rash. RMSF is the most commonly fatal tick-borne disease in the United States. We are developing and evaluating an innovative immunotherapeutic treatment for RMSF and other globally distributed rickettsial infections.

PI_NAMEs: WYCOFF, KEITH  (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Acute;Animal Model;Anti-Bacterial Agents;Anti-Infective Agents;Antibiotics;Antibodies;antimicrobial;Arthropods;Bacteria;Bacterial Infections;bacterial resistance;Binding;Biological Availability;Biophysics;Blood Vessels;Body Regions;Chimeric Proteins;Clinical;Communities;Complement;Complement Activation;Complement Factor H;complement system;Conflict (Psychology);Creativeness;Dangerousness;design;Development;efficacy evaluation;Endemic Flea-Borne Typhus;Endothelium;Etiology;Evolution;Exanthema;Extravasation;Fatality rate;Fever;fighting;Foundations;Headache;Human;Hypovolemia;Hypovolemics;IgG3;immune clearance;Immune Evasion;Immune system;Immunotherapeutic agent;improved;in vivo Model;Infection;innovation;Lead;Macrophage;Mediating;Membrane Proteins;Methods;Modeling;Molecular;Multiple Organ Failure;novel;novel strategies;novel therapeutic intervention;Parasites;pathogen;pathogenic bacteria;Pathogenicity;Phagocytosis;Phase;prevent;Prognosis;Property;prophylactic;Proteins;rapid diagnosis;Recombinants;Rickettsia;Rickettsia Infections;Rickettsia parkeri;Rickettsia rickettsii;Rocky Mountain Spotted Fever;Safety;sensor;spotted fever;Surface;Sushi Domain;Theft;Therapeutic;tick bite;Tick-Borne Diseases;transmission process;United States;Variant;Vascular System;Viral Hemorrhagic Fevers;weapons

PROJECT_TITLE: Factor H-Fc Fusion as a Pre-Exposure Prophylactic for Rickettsia Infections


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetic Testing;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PI_NAMEs: ANHOLT, ROBERT R. H;MASINO, AARON J (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Address;Affect;Algorithms;Artificial Intelligence;artificial intelligence method;Biological;biomedical ontology;Caring;Centers of Research Excellence;Clinical;Clinical Decision Support Systems;clinical diagnosis;Complex;Custom;Data;Data Analyses;data fusion;Databases;deep learning;deep learning model;Diagnosis;Diagnostic;Disease;Face;flexibility;Frustration;Gene Expression;Genes;Genetic;genetic disorder diagnosis;Genetic Predisposition to Disease;genetic testing;Genomics;graph neural network;Health;Human Genetics;improved;in silico;Individual;knowledge graph;large language model;learning strategy;method development;Methods;Multiomic Data;novel;Ontology;Outcome;Pathogenicity;Pathway interactions;Patients;phenomics;Phenotype;Population;precision genetics;Rare Diseases;rare genetic disorder;Recommendation;Research;Research Personnel;Risk;RNA Splicing;Sampling;Specific qualifier value;System;Testing;Tissues;transcriptomics;United States;unstructured data;Variant

PROJECT_TITLE: Integration of Biomedical Ontologies with Deep Learning AI for Research and Diagnosis of Rare Diseases


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Genetics;Human Genome;Nanotechnology;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: ANHOLT, ROBERT R. H;ARNO, GAVIN  (contact)

PROJECT_TERMS: Affect;bioinformatics tool;Blood;Candidate Disease Gene;Centers of Research Excellence;Chemistry;Classification;clinical diagnostics;clinical sequencing;clinically relevant;Code;Collaborations;Data Set;Diagnosis;Diagnostic;Disease;disease diagnosis;Environment;Exons;Family;Future;Genes;Genetic;genetic analysis;Genetic Diseases;Genome;genome sequencing;Genomic medicine;Genomic Segment;genomic variation;Genomics;Goals;Haplotypes;Heritability;human disease;Human Genetics;improved;Informatics;Inherited;Laboratories;Leadership;Left;Length;Mendelian disorder;Messenger RNA;Methodology;Methods;Modeling;Molecular Diagnosis;nanopore;next generation sequencing;novel;Pathogenicity;Patients;Persons;Phase;Rare Diseases;Research;Retinal Dystrophy;Reverse Transcriptase Polymerase Chain Reaction;RNA Splicing;Sampling;success;Techniques;Technology;Testing;Time;Untranslated RNA;USH2A gene;Variant;variant of unknown significance;whole genome;Work

PROJECT_TITLE: Improving Rare Disease Diagnosis With Advanced Genetics and Long Read Sequencing


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: NARRATIVE HIV-1 is the virus responsible for causing acquired immunodeficiency syndrome (AIDS), affecting nearly 38 million people worldwide as of 2021. Despite progress in treating those infected with HIV-1, there remains a growing need for therapeutics to prevent the infection and spread of HIV-1. This proposal focuses on dissecting a critical step during HIV-1 infection, which is the hijacking of host motor proteins and their cargo adaptors to support the transport of HIV-1 to the cell nucleus after membrane fusion.

PI_NAMEs: CAMPBELL, EDWARD M;CIANFROCCO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adaptor Signaling Protein;Affect;Attenuated;Binding;Binding Sites;Biochemical;Biological Assay;Capsid;Cell membrane;Cell Nucleus;cell type;Cells;Complex;crosslink;Cryo-electron tomography;Cryoelectron Microscopy;Cytoplasm;Data;Development;Diffusion;Dimerization;Docking;Dynein ATPase;Ensure;experimental study;flexibility;Fluorescence;Fluorescence Microscopy;Future;Genome;Goals;HIV-1;In Situ;In Vitro;Individual;Infection;Infection prevention;Life Cycle Stages;Light;Link;live cell imaging;Mass Spectrum Analysis;Mediating;Membrane Fusion;Microtubules;Modeling;Molecular;molecular modeling;Motility;Motor;Movement;novel;Nuclear Pore;particle;Persons;prevent;Proteins;reconstitution;recruit;Reporting;Reverse Transcription;Role;single molecule;Site;System;T-Lymphocyte;Testing;Therapeutic;therapeutic target;tool;trafficking;Vesicle;Viral;viral DNA;Virus;Walking;Work

PROJECT_TITLE: Determining the Molecular Basis for HIV-1 Retrograde Trafficking


ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative This is a highly significant project for the public health because it will elucidate the mechanism for drug-resistance during treatment of HIV/AIDS with HARRT.

PI_NAMEs: MA, AO  (contact);ZHENG, YONG-HUI

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: Active Sites;Acute;Affect;Affinity;Anti-viral Agents;Binding;Biological Assay;combat;Complex;computerized tools;design;Drug Design;Drug resistance;Free Energy;Genetic;global health;Goals;Heart;HIV;HIV drug resistance;HIV-1;HIV-1 protease;HIV/AIDS;Individual;Infection;insight;Intuition;Investigation;Ligand Binding;Ligands;Methods;Modification;Molecular Conformation;mutant;Mutation;next generation;novel;Pathway interactions;Peptide Hydrolases;Pharmaceutical Preparations;Physics;Process;Protease Inhibitor;Protein Conformation;Protein Dynamics;Proteins;Protocols documentation;Public Health;rational design;Reaction;Resistance;resistance mechanism;resistance mutation;Series;Site;Sodium Chloride;standard care;Structure;Testing;tool;Variant;Vertebral column;virology

PROJECT_TITLE: A Systematic Toolkit for Counteracting HIV Drug Resistance with Protein Structural Dynamics


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition;Obesity

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

PI_NAMEs: LUTKEWITTE, ANDREW  (contact);THYFAULT, JOHN P

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Abdomen;Adipocytes;Adipose tissue;Adult;alpha-glycerophosphoric acid;Automobile Driving;Biopsy;Carbohydrates;Carbon;Chronic;comorbidity;Data;detection of nutrient;Diglycerides;Disease;Disease Progression;Enzymes;Fatty Acids;Fatty Liver;fatty liver disease;Functional disorder;Generations;Genes;Glycerol;Goals;Hepatic;Human;Insulin Resistance;insulin sensitivity;Kansas;Link;lipid biosynthesis;Lipids;lipine;Lipodystrophy;Lipolysis;Liver;Liver diseases;liver metabolism;Metabolic;Metabolic Diseases;Metabolism;Modeling;Molecular;multiple omics;Mus;Names;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;Nutrient;obese patients;Obesity;Operative Surgical Procedures;Organ;overexpression;Pathway interactions;Patients;Phenotype;Phosphatidate Phosphatase;phosphoproteomics;Portal vein structure;Process;Protein Kinase;Regulation;Research;Risk Factors;Role;Source;Testing;Thinness;Triglycerides;Visceral

PROJECT_TITLE: Dysfunctional adipose tissue's role in hepatic metabolic disease


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Intestinal epithelial cells and T lymphocytes play crucial roles in the regulation of inflammatory bowel diseases (IBD), which are regulated by gut bacterial metabolites, including short chain fatty acids; however, the way in which short chain fatty acids affect the interactions between intestinal epithelial cells and T lymphocytes in IBD has not been well-understood. In this application, we will investigate whether short chain fatty acids affect T cell function by acting on intestinal epithelial cells, and the role of such regulation in IBD. If successful, this application will provide novel therapeutic targets for treating IBD.

PI_NAMEs: CONG, YINGZI  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: absorption;Acetates;Affect;Animal Model;Antigens;Butyrates;Carbohydrates;CD4 Positive T Lymphocytes;Cell Physiology;cell type;Cells;Chromatin;Colitis;comparative;conditional knockout;Data;Development;Diet;Disease;dysbiosis;Enzymes;Epigenetic Process;Epithelial Cells;Epithelium;Erythroid;Extrinsic asthma;EZH2 gene;feeding;Fiber;Flagellin;Flavonoids;Gene Expression;Genetic Polymorphism;gut bacteria;gut inflammation;gut microbiota;Histone H3;histone methylation;Histones;Homeostasis;host-microbe interactions;Immune;Immune response;Immune system;In Vitro;in vivo;Inflammation;Inflammatory Bowel Diseases;interest;Interleukin-10;intestinal epithelium;intestinal homeostasis;Intestines;IRF4 gene;Kinetics;Knockout Mice;Knowledge;Licensing;Lysine;Maintenance;Mediating;Metabolic;metabolomics;microbiota;microbiota metabolites;Molecular;Mucous Membrane;Mus;new therapeutic target;novel;Nuclear;Oral;pathogen;Pathogenesis;Pathway interactions;Patients;Pattern;Physiological;Play;preservation;prevent;Prevention;Production;Propionates;Regulation;Risk;Role;small molecule;Spontaneous colitis;Stimulus;T cell response;T-Lymphocyte;Testing;Volatile Fatty Acids

PROJECT_TITLE: Gut microbiota metabolite sensing licenses IEC to cross talk with T cells to inhibit intestinal inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-H(03)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Patient Safety;Prevention

ORG_CITY: NEW YORK

ORG_NAME: PIP CARE, INC.

PHR: NARRATIVE Forty-eight million surgeries are performed annually in the US. Improved perioperative care could lower the risk of complications, long hospital stays, readmission, and death, but patients often lack access to comprehensive perioperative care guidance and support. Pip Care is developing a personalized, interactive surgical journey platform with live health coaching that works directly with patients and health systems to optimize the perioperative care process.

PI_NAMEs: HOLDER-MURRAY, JENNIFER ;KALUHIOKALANI, KATHY ;MAHAJAN, AMAN  (contact)

PROGRAM_OFFICER_NAME: BURKE, CATHERINE

PROJECT_TERMS: Abdomen;Admission activity;Advanced Development;Adverse event;Anemia;Benchmarking;Body Weight decreased;care coordination;care providers;Caring;Cause of Death;Cessation of life;Chest;Client satisfaction;Clinical;Clinical assessments;clinical care;Clinical Pathways;Clinical Research;comorbidity;Complex;Computerized Medical Record;Confusion;Conscience;cost;Data;Day Surgery;diabetes management;digital health;Education;efficacy evaluation;Emotional;empowerment;experience;Family;Feedback;fitness;Frequencies;Future;Goals;Habilitation;Health;Health Care Costs;Health Insurance Portability and Accountability Act;Health system;Healthcare;Healthcare Industry;high risk;hospital readmission;Human;hypertension control;improved;Industry;innovation;Intake;Joints;Learning;Length of Stay;Managed Care;Measures;Medical;Medical center;modifiable risk;Motivation;novel;nutrition;Nutritional;Operative Surgical Procedures;Orthopedics;Outcome;Outcome Measure;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Perioperative;Perioperative Care;Phase;Pilot Projects;Postoperative Complications;Postoperative Period;Preparation;primary endpoint;Process;Randomized, Controlled Trials;readmission rates;Resources;Risk;Risk Factors;Self Efficacy;Small Business Technology Transfer Research;smoking cessation;Source;standard of care;success;Touch sensation;United States;Universities;usability;Vertebral column;virtual health;Work

PROJECT_TITLE: Novel Digital Health Platform with Virtual Health Coach for Improving Perioperative Patient Outcomes and Care Coordination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-J (10)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases;Tuberculosis

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE It is poorly understood how well the drugs used to treat deadly CNS infections in individuals with HIV actually penetrate into compartments of the brain. This study will leverage samples from CSF obtained during treatment, and brain tissues collected during autopsy, to define the concentrations of these drugs, and determine how well these drugs work in the brain to remove the infections.

PI_NAMEs: NICOL, MELANIE RAE (contact)

PROGRAM_OFFICER_NAME: SRINIVASAN, SUDHA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS-Related Opportunistic Infections;Amphotericin;anti-fungal agents;Anti-Infective Agents;Antitubercular Agents;Area;Autopsy;Biological;Biological Assay;Brain;brain parenchyma;brain tissue;Cell Count;Cells;Central Nervous System;Central Nervous System Agents;Central Nervous System Diseases;Central Nervous System Infections;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Cessation of life;Clinical;Clinical Pharmacology;Clinical Trials;Collaborations;Cryptococcal Meningitis;Cryptococcus;cytokine;Data;Development;Disease;Disease Reservoirs;Doctor of Pharmacy;Doctor of Philosophy;Dose;drug distribution;drug efficacy;Drug Exposure;Drug Kinetics;Drug usage;experience;Exposure to;extracellular;Fluconazole;Flucytosine;Formulation;Future;Goals;Granuloma;HIV;Human;Immune response;improved;improved outcome;Individual;Infection;Inflammation;Inflammatory;Infrastructure;Investigation;Knowledge;Lead;Lesion;Liposomes;Measures;member;Meningeal Tuberculosis;Modeling;Morbidity - disease rate;mortality;Neurocognition;Neurocognitive;novel;novel therapeutics;Opportunistic Infections;Oral;Outcome;Participant;pathogen;Pathogenicity;Pathologist;Pathway interactions;Patient-Focused Outcomes;Penetration;Performance;Persons;Pharmaceutical Preparations;pharmacodynamic model;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacotherapy;phase II trial;Plasma;Population;predict clinical outcome;Predisposition;Procedures;Protocols documentation;Regimen;Research;research clinical testing;Research Personnel;Resistance;response;Role;Sampling;Site;Specimen;survival outcome;synergism;targeted treatment;Testing;Therapeutic;Tissue Banks;Tissues;Training;treatment duration;Treatment Protocols;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Uganda;Work

PROJECT_TITLE: Improving outcomes in HIV-associated opportunistic infections using CNS pharmacokinetics and pharmacodynamics

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Bioengineering;Neurosciences;Pediatric

ORG_CITY: MOUNT PLEASANT

ORG_NAME: APEX ORTHOPAEDIC TECHNOLOGIES LLC

PHR: Project Narrative Early-onset spinal deformity (EOSD) is an important pediatric problem. Currently available forms of surgical treatment fail to support optimal spinal growth and pulmonary development and are plagued by high complication rates. The proposed studies will explore a novel type of instrumentation called R-FIX (Rib-FIXation System) that utilizes rib fixation to correct EOSD.

PI_NAMEs: BONTHIUS, DANIEL JAMES;GROSS, RICHARD H. (contact);YAO, HAI

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: 10 year old;3-Dimensional;Acute;Adolescent;Adult;Affect;Animal Model;Apical;Applications Grants;Award;biomaterial compatibility;biomechanical test;Biomechanics;Biomedical Engineering;Breakthrough device;Cadaver;Cardiopulmonary;Chest;Child;Childhood;Clinical Trials;Complex;Complication;Contracts;cytotoxicity;Data;Deformity;design;Development;Disease;Distal;Early Intervention;early onset;Early treatment;economic cost;effective therapy;Effectiveness;efficacy evaluation;Epiphysial cartilage;Etiology;Failure;Family;Family suidae;Feedback;follow-up;Fracture;Future;Goals;Grant;grasp;Growth;Heart Diseases;high risk;Histologic;Human;Hyperkyphosis;Idiopathic scoliosis;Implant;implant design;improved;in vivo;innovation;instrument;instrumentation;Kyphosis deformity of spine;Left;Life;Lung;manufacture;Manufacturer;Mechanics;Medical;Medical Device;meetings;Methods;Modernization;mortality;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nervous System Trauma;Neurologic Deficit;neurosurgery;new technology;novel;Oncology;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Osteoporosis;Pathology;Patients;performance tests;Phase;Positioning Attribute;Prevention;Procedures;Process;Protocols documentation;psychologic;Quality Control;Research;Respiratory Failure;rib bone structure;Risk;Rod;Safety;safety assessment;sample fixation;scoliosis;Secondary to;Series;Site;skeletal;Small Business Innovation Research Grant;Societies;Spinal;Spinal Cord;Spinal cord injury;Spinal Fusion;spine bone structure;Sterility;sterility testing;Structure;Surgeon;Surveys;System;Techniques;Technology;Testing;Torsion;Toxicity Tests;Traction;Treatment Cost;Universities;Validation;Vertebral column

PROJECT_TITLE: R-FIX (Rib-FIXation) Spinal Growth System for Early-onset Spinal Deformity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-A (11)]


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Proteins do not exist in a vacuum; rather, proteins must function in a crowded cellular environment and need to precisely interact with other molecules to execute proper cell signaling. I will determine how communities of proteins assemble and disassemble to control cellular metabolism, in the process uncovering fundamental principles underlying formation of cellular machines necessary for life. In the long term, this investigation will lead to new insights of how damaged protein assembly may contribute to various metabolic disorders, with broad implications in diabetes, inflammation, and cancer research.

PI_NAMEs: BROWN, BREANN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TITLE: Off the beaten path(way): Spatiotemporal investigation of protein assemblies controlling mitochondrial metabolism


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE In the global HIV response, advancing engagement in HIV service through the lens of implementation science is critical to continued success. Over the last six years, I have used my K24 award to support 32 mentees (40% who are underrepresented in medicine and research and 65% women), mentored 19 total successful K- series applications (as primary mentor in 6), fostered 87 total publications with my mentees, all addressing critical issues in the engagement and retention in care. I propose to use this proposal for a renewal of my K24 award to build on my success to date by proposing new directions: (a) increase the effectiveness of my mentorship for emerging leaders and future mentors in HIV implementation science through a novel co-pilot model using an “Appreciative Inquiry” approach; (b) cultivate a rewarding professional ecosystem for each mentee made up of peer-to-peer and mentee-to-mentor relationships that will enable trainees to thrive professionally; and (c) help trainees maximize the impact of their scholarship through conceptualizing the wider impact of their work (through using the Translational Sciences Benefits Model) as well as dedicated training and coaching in science communications.

PI_NAMEs: GENG, ELVIN H. (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: adaptive intervention;Address;apprenticeship;Area;Attitude;Awareness;Behavior;Behavior Therapy;Behavioral trial;Belief;Blinded;Botswana;Cardiovascular system;Caring;Cluster randomized trial;Communication;communication behavior;cost;Data;Data Analyses;Dedications;Disease;Disease Management;Ecosystem;Effectiveness;Elements;Epidemic;experience;Family;Fostering;Foundations;Funding;Future;Government;Grant;health care delivery;Health Care Surveys;Health Personnel;Heterogeneity;HIV;HIV/AIDS;hypertension control;implementation science;implementation strategy;improved;Individual;Institution;interest;Intervention;intervention delivery;K-Series Research Career Programs;Kenya;Lead;Leadership;Learning;lens;Light;Literature;Measures;Medical Research;Medicine;Mental Health;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);Modeling;Mozambique;multidisciplinary;National Heart, Lung, and Blood Institute;Nigeria;novel;Outcome;Output;pandemic disease;Paper;Pathway interactions;patient oriented;patient oriented research;patient response;Patient Self-Report;Patient-Centered Care;Patients;peer;person centered;Policies;Population;preference;programs;Provider;Psychology;Public Domains;Public Health;Publications;randomized trial;Reporting;Research;Research Activity;Research Infrastructure;Research Institute;Research Personnel;response;retention rate;Rewards;Role;Running;Scholarship;Science;secondary analysis;Sequential Multiple Assignment Randomized Trial;Series;service delivery;Services;skills;South Africa;success;Surveys;Testing;Therapeutic;Time;Touch sensation;Training;Training Support;translational impact;Translational Research;Tuberculosis;Uganda;United States National Academy of Sciences;United States National Institutes of Health;United States Public Health Service;Universities;Washington;Woman;Work;Zambia

PROJECT_TITLE: MENTORING MULTIDISCIPLINARY PATIENT-ORIENTED RESEARCH IN ENGAGEMENT IN HIV CARE

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Radiation Oncology;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: NARRATIVE Irreversible electroporation (IRE) was developed to destroy cancer cells using electrical pulses without damaging nearby vital structures. However, technical challenges with IRE have led to slow clinical adoption and our invention, termed high- frequency IRE (H-FIRE), overcomes these challenges. This proposal will advance “next generation” H-FIRE for use with a single needle delivery device to treat liver tumors that cannot be treated by other means.

PI_NAMEs: DAVALOS, RAFAEL VIDAL (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Ablation;Acute;Address;Adjuvant Chemotherapy;Adopted;Adoption;advanced disease;Affect;Age;Algorithms;Anatomy;Animal Model;Animals;Architecture;Biliary;Biological Models;Blood Vessels;breast cancer metastasis;cancer cell;Cancer Etiology;Canis familiaris;Cardiac;Cardiac Output;Cell Death Induction;cell killing;Cell membrane;Cells;Charge;Cholangiocarcinoma;Chronic;Cirrhosis;Clinical;Colorectal;Complex;Custom;Data;Data Collection;Defect;Desiccation;design;Development;Devices;Diagnosis;Disease;electric field;Electrodes;Electroporation;Environment;Etiology;Evaluation;Evolution;Excision;experience;Extrahepatic;Family suidae;Frequencies;Hemangiosarcoma;Hepatic;Hepatic Mass;Homeostasis;Human;Image-Guided Surgery;in silico;In Situ;in vivo;in vivo Model;innovation;interest;intrahepatic cancer;invention;Length;Link;Liver;Liver diseases;liver function;Liver neoplasms;Location;Malignant Neoplasms;manufacture;Measurement;Medical;Metastatic Neoplasm to the Lung;microsensor;microwave ablation;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;nano;nanopore;Necrosis;necrotic tissue;Needles;next generation;novel;Operative Surgical Procedures;Organ Transplantation;Outcome;Palliative Care;Paralysed;Pathologic;Pathology;patient population;Patient Selection;patient subsets;Patients;Performance;Perfusion;Phase;Physiologic pulse;pre-clinical;Primary carcinoma of the liver cells;Procedures;Property;Protocols documentation;prototype;Radiofrequency Interstitial Ablation;Recurrence;Reporting;Reproducibility;Research;Resected;Residual state;response;Risk;Risk Factors;Safety;Solid Neoplasm;Staging;Structure;Survival Rate;System;Technical Expertise;Technology;technology development;temporal measurement;Testing;Thermal Ablation Therapy;Time;Tissues;Translating;translational approach;Translations;Transplantation;tumor;Vascularization;Veterinary Schools

PROJECT_TITLE: Development and application of non-thermal high frequency IRE to treat hepatic tumors

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ORG_CITY: WASHINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Worldwide, there are 38 million people living with HIV infection. A recent report shows that HIV infected patients have twice the risk of developing cardiovascular disease, and globally, the burden has tripled in the last 20 years. In patients with HIV infection, activation of the immune system and systemic inflammation have been associated as the main drives of cardiovascular events. In this proposal, we will investigate the underlying mechanisms driving vascular damage/inflammation during HIV infection by focusing on extracellular granzymes (enzymes) secreted by the CD8 T cells that promote endothelial inflammation and the blockade of this pathway to vascular inflammation and cardiovascular risk.

PI_NAMEs: CATALFAMO, MARTA L. (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;Adaptive Immune System;Address;angiogenesis;Angiopoietin-2;Angiotensins;antagonist;antiretroviral therapy;Apolipoprotein E;Arterial Fatty Streak;Atherosclerosis;Automobile Driving;Biological;Blood;Blood Platelets;Blood Vessels;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Carotid Artery Plaques;CD4 Lymphocyte Count;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Chronic;clinically significant;Coagulation Process;Coronary artery;cytokine;cytotoxic;Data;Development;differential expression;Disease;Disease Progression;disorder risk;DNA;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;Event;extracellular;Extracellular Matrix;Functional disorder;Generations;Granzyme;HIV;HIV Infections;Hypoxia;IL8 gene;Immune;immune activation;Immune system;In Vitro;Infection;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;Injury;Interleukin-6;Ions;Knowledge;Literature;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Mediating;Memory;migration;Molecular;Molecular Target;Monoclonal Antibodies;Morbidity - disease rate;mortality;novel;organ on a chip;PAR-1 Receptor;Pathway interactions;Patients;perforin;Peripheral;Persons;Phenotype;Physiological;Play;Primary Prevention;Production;Protease Inhibitor;receptor;recruit;Regulation;Reporting;Risk;Risk Factors;Role;Serine Protease;Signal Transduction;Site;Stream;System;systemic inflammatory response;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;Thrombin;Thrombin Receptor;Tissues;trafficking;Trauma;vascular inflammation;vascular injury;Vascular Permeabilities;Virus;Work

PROJECT_TITLE: The proinflammatory functions of granzymes and their impact on endothelial inflammation/injury

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Osteoarthritis;Pain Research;Prevention;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE  Hand osteoarthritis is a painful disorder that impairs an individual's ability to perform activities of daily life but has been the subject of little research and has few therapeutic options. Growing evidence suggests that per- and poly-fluoroalkyl substances (PFAS), which are grease-resistant chemicals found in everyday items (e.g., clothing, furniture), relate to self-reported diagnosis of osteoarthritis. Our goal is to explore the relationship between these chemicals and hand osteoarthritis to help inform public health policies, identify susceptible populations, and suggest therapeutic targets.

PI_NAMEs: DRIBAN, JEFFREY B (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Address;adipocyte differentiation;Affect;Age;Architecture;Area;articular cartilage;Articulation;Automobile Driving;base;Biological Assay;Body mass index;bone;bone health;bone loss;bone metabolism;Bone Spur;Bone structure;burden of illness;Cartilage;Characteristics;Chemicals;Clinical;Clothing;cohort;Cohort Studies;Cross-Sectional Studies;Data;Data Set;Degenerative polyarthritis;Development;Diagnosis;Disease;Endocrine Disruptors;Environment;Environmental Health;Environmental Pollutants;Environmental Risk Factor;Exposure to;fatty acid oxidation;Functional disorder;Furniture;Goals;Hand;Hand Osteoarthritis;Hand's disease;Health;Health Policy;Impairment;Incidence;Individual;Inflammation;Inflammation Mediators;Insulin Resistance;interest;Interleukin-1 beta;Joints;Kellgren-Lawrence grade;Life;Longevity;Longitudinal Studies;Macrophage;Marketing;mast cell;Measures;Mediating;Metabolic;Metabolic syndrome;Mission;Modeling;modifiable risk;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;Obesity;Outcome;Oxidative Stress;Pain;Pain Research;Participant;Pathogenesis;Pathway interactions;Patient Self-Report;peer;perfluorooctane sulfonate;perfluorooctanoic acid;Peroxisome Proliferator-Activated Receptors;Poly-fluoroalkyl substances;Population;Predisposition;Prevalence;primary outcome;Production;Proliferating;Public Health;radiological imaging;Reporting;Research;Research Personnel;Resistance;response;Risk;Risk Factors;Sampling;secondary analysis;Serum;Severities;sex;Strategic Planning;Structure;Sum;Synovitis;Testing;Therapeutic;therapeutic target;Thumb structure;Time;Tissues;United States;Up-Regulation;Width

PROJECT_TITLE: Environmental Factors Associated with the Development of Osteoarthritis

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE Veterinary diagnostic laboratories play significant roles in safeguarding animal and public health by providing diagnostic services, responding to disease outbreaks, developing new testing methods and protocols, and advocating relevant governmental regulations. Protecting and advancing veterinary diagnostic infrastructure and coordination of Vet-LIRN member laboratories, such as the MU VMDL, will strength FDA CVM’s mission of promptly responding to high priority microbial and chemical contaminations of feed and veterinary drugs as well as the transmission of antimicrobial resistance from animals to humans.

PI_NAMEs: ZHANG, SHUPING  (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: FDA Vet-LIRN Site Application - Tier I Lab Renewal

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-K (01)]


ORG_CITY: DENVER

ORG_NAME: BIOMEDINNOVATIONS, INC.

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE (Narrative) Kidney transplantation is currently the optimal renal replacement therapy due to reduced morbidity and mortality, better quality of life, and a decreased cost compared to dialysis. Unfortunately, transplants are severely limited by a shortage of donor kidneys available for transplantation, with over 90,000 patients on the waiting list. This project, if successful, will expand access to life-saving kidney transplants for those on the waitlist.

PI_NAMEs: BARBAS, ANDREW SERGHIOS;NEUSNER, ROBERT  (contact);ROY-CHAUDHURY, PRABIR

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Adoption;American;Anoxia;Autologous Transplantation;Biochemistry;Blood;Cardiovascular system;Caring;Cessation of life;Clinical;clinical application;Clinical assessments;clinical efficacy;Clinical Trials;Coagulation Process;commercialization;comorbidity;Computer software;cost;cost comparison;Cost Savings;Creatinine;Cryopreservation;Data;design;Device or Instrument Development;Devices;Dialysis procedure;End stage renal failure;Engineering;Failure;Family suidae;Flushing;Foundations;Future;Good Manufacturing Process;graft function;Graft Survival;Health;high risk;Histology;Human;Ice;Improve Access;improved;Injury;Investments;ischemic injury;Kidney;kidney preservation;Kidney Transplantation;Life;Measures;Methods;Modeling;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;natural hypothermia;Organ;Organ Preservation;Organ Transplantation;Outcome;Output;Oxygen;Patients;payment;Performance;Perfusion;Physiologic pulse;Pilot Projects;Policies;porcine model;post-transplant;pre-clinical;preservation;Process;public health relevance;Pulsatile Flow;Quality of life;Renal Replacement Therapy;Reperfusion Therapy;Reporting;Research Personnel;Research Priority;secondary outcome;Secure;Serum;Small Business Innovation Research Grant;standard of care;success;Techniques;Technology;Temperature;Testing;Tissues;transplant model;Transplantation;Transportation;Urine;usability;Waiting Lists;Warm Ischemia;Whole Blood

PROJECT_TITLE: Platform for Extended Kidney Preservation Via Subnormothermic Perfusion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-R (11)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: Watertown

ORG_NAME: ALDATU BIOSCIENCES, INC.

PHR: Crimean-Congo hemorrhagic fever virus (CCHFV)—listed among the urgently concerning pathogens prioritized in the WHO R&D Blueprint List of Priority Diseases— causes severe hemorrhagic fever in humans that is difficult to clinically diagnose as the early (i.e., pre-hemorrhagic) stages present with non-specific symptoms associated with a range of febrile illnesses that are also displayed by other infectious agents endemic to affected areas e.g., malaria, yellow fever, dengue fever, influenza, or Lassa fever. This Phase IIB SBIR submission will commercialize the results of our successful Phase II SBIR where we leveraged the unique capabilities of our qPCR-enabling technology, PANDAA, to successfully market the first rapid, sensitive molecular diagnostic CCHFV assay with pan-lineage coverage and superior performance compared to existing diagnostics that won’t be affected by genetic changes in new viral variants. We will establish the regulatory and quality frameworks necessary to manufacture the associated product, PANDAA-CCHFV, that will provide a rapid, standardized testing option for all CCHF-endemic regions and can be deployed using pre-existing qPCR equipment in central labs to radically improve the CCHFV diagnostic workflow by reducing test complexity, time burden and costs without sacrificing accuracy.

PI_NAMEs: MACLEOD, IAIN JAMES (contact)

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: Acceleration;Accounting;Address;Adoption;Affect;African;Animals;Area;associated symptom;Binding Sites;Biological Assay;Blood;Body Fluids;Caring;Case Fatality Rates;Certification;cGMP production;Clinical;clinical diagnosis;clinical diagnostics;Clinical Research;Clinical Sensitivity;Cold Chains;commercialization;Compensation;Contracts;cost;Country;Crimean Hemorrhagic Fever;Crimean-Congo Hemorrhagic Fever Virus;Cyclic GMP;Data;Dengue Fever;design;Detection;Development;Diagnosis;Diagnostic;diagnostic assay;Diagnostic tests;diagnostic value;Disease;Economics;Ensure;Environment;epidemic potential;Equipment;Evaluation;Exhibits;Fever;Fluorescent Probes;Funding;Genetic Polymorphism;Genetic Variation;Genomic Segment;genomic variation;Genomics;Geographic Distribution;Geography;global health;Health;Hemorrhage;Human;Humidity;improved;in-vitro diagnostics;Individual;Infection;Infectious Agent;Influenza;Infrastructure;innovation;International;international partnership;Intervention;Laboratories;Lassa Fever;Liberia;Life;Logistics;Malaria;Management Information Systems;manufacture;Marketing;Mediation;Medical;Medical Device;Methods;Molecular;molecular diagnostics;Mutation;new epidemic;Nigeria;Notification;novel;Nucleotides;pathogen;pathogen genomics;Performance;Persons;Phase;Positioning Attribute;Prevention;priority pathogen;Process;Qualifying;Quality Control;Reporting;Reproducibility;research and development;Resource-limited setting;Resources;RNA;Sampling;Sensitivity and Specificity;Shipping;Sierra Leone;Site;Small Business Innovation Research Grant;Specific qualifier value;Specificity;Standardization;Symptoms;System;Technology;technology platform;Testing;tick-borne virus;Ticks;Time;transmission process;Undifferentiated;Validation;Variant;vector tick;Viral;viral detection;Viral Hemorrhagic Fevers;viral transmission;Virus Diseases;Yellow Fever;Zoonoses

PROJECT_TITLE: PANDAA for universal, pan-lineage molecular detection of Crimean-Congo Hemorrhagic Fever virus.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (13)]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: Aurora

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: High rates of trauma exposure, anxiety and post-traumatic stress disorder (PTSD) in low-income, minority, urban populations underscore the urgent need for research in this under-represented group. Further, adolescence is a time when many mental illnesses emerge, due to biological and environmental risk factors. Research on the impact of these factors on biomarkers will significantly contribute to empirically grounded early intervention strategies that may ultimately increase resilience in this population.

PI_NAMEs: BALE, TRACY L (contact);JOVANOVIC, TANJA

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: 18 year old;Adolescence;Age;Anxiety;Biological;Biological Assay;Biological Markers;Birth;Black American;black women;Characteristics;Childhood;Chronic;cohort;conditioned fear;Development;Disease;Early Intervention;Environmental Risk Factor;experience;Exposure to;extracellular vesicles;Fright;Health;health inequalities;human subject;Individual;Individual Differences;Interpersonal Violence;Intervention;Life;Low income;Mental disorders;Minority;Mood Disorders;neuropsychiatric disorder;novel;Outcome;Participant;pediatric trauma;Physiological;Plasma;Population;Post-Traumatic Stress Disorders;promote resilience;Proteins;Proteomics;Research;Resources;response;Risk;Specificity;Stress;Study Subject;Time;Tissues;Trauma;trauma exposure;Underrepresented Populations;Urban Population;urban setting;violence exposure;Vulnerable Populations

PROJECT_TITLE: Extracellular vesicles as biomarkers of trauma exposure and PTSD risk


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Precision Medicine

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The MACS/WIHS Combined Cohort Study is the most prominent representative cohort of HIV-infected men and women in the United States. Despite the availability of effective medications, there is a variation in response to these medications, with some patients experiencing side effects while others do not achieve their target goal of HIV treatment. This project takes a novel approach to use information from hundreds of small molecules measured in the blood of men and women treated with two different HIV medications, dolutegravir, and tenofovir alafenamide fumarate, to discover new genes that can help us better understand this variation in response including to these two medications.

PI_NAMEs: HYSI, PIRRO G;TAMRAZ, BANI  (contact)

PROGRAM_OFFICER_NAME: SHARP, GERALD B

PROJECT_TERMS: absorption;Adherence;Adverse effects;Affect;analysis pipeline;Anti-Retroviral Agents;antiretroviral therapy;Aspirin;Biological Markers;Blood;Clinical;clinically significant;cohort;Cohort Studies;Data;Data Set;Development;Diphosphates;Dose;Drug Controls;Drug Exposure;Drug Kinetics;drug metabolism;Effectiveness;Escitalopram;ethnic diversity;Ethnic Origin;experience;Fumarates;Future;Gender;gene discovery;Genes;Genetic;genetic association;Genetic Polymorphism;genetic variant;genome wide association study;genomic data;Genomics;Goals;HIV;improved;Individual;Insulin Resistance;Lead;longitudinal analysis;Measurable;Measures;Medicine;men;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;metabolome;metabolomics;Modeling;Modern Medicine;multi-ethnic;multiple omics;novel;novel strategies;Organism;Participant;Pathway interactions;Patients;Peripheral;personalized predictions;Persons;Pharmaceutical Preparations;Pharmacogenetics;Pharmacometabolomics;Plasma;population based;predicting response;Process;Prodrugs;Proxy;Regimen;Research;Research Design;Resolution;response;Role;Sample Size;Sampling;Series;Sertraline;side effect;small molecule;Tenofovir;The Multicenter AIDS Cohort Study;Therapeutic Effect;Time;Tissues;Toxic effect;Treatment Failure;treatment strategy;Twin Multiple Birth;United Kingdom;United States;United States National Institutes of Health;Variant;Viral;Waist-Hip Ratio;Weight;Weight Gain;Woman;Women's Interagency HIV Study;women's treatment

PROJECT_TITLE: Quantifying genomic and pharmacometabolomic differences in antiretroviral exposure in MACS/WIHS Combined Cohort Study


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care

ORG_CITY: DURHAM

ORG_NAME: 3-C INSTITUTE FOR SOCIAL DEVELOPMENT

PHR: Project Narrative There is an urgent public health need to increase availability of and access to evidence-based treatments for childhood obesity. Technology can be leveraged to bring pediatric obesity interventions into real-world practice, with meaningful and sustainable public health impact by addressing barriers to treatment (e.g., lack of providers, logistical barriers). This Direct to Phase II SBIR project will expand upon an existing interventionist training platform to develop and pilot test an innovative, “all-in-one" online pediatric weight management intervention, increasing access to guideline-based obesity care for children and adolescents with obesity and their families.

PI_NAMEs: DEROSIER, MELISSA E. (contact);EPSTEIN, LEONARD H;WILFLEY, DENISE ELLA

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: 18 year old;acceptability and feasibility;Address;Adolescent;Adult;Advisory Committees;Affect;aged;barrier to care;Behavior Therapy;Behavioral;behavioral outcome;Caregivers;Caring;Child;Child Care;Childhood;Clinic;Collaborations;commercialization;comorbidity;comparative;Computer software;Consultations;Data;Development;digital;digital health;digital intervention;digital platform;digital technology;Disease;Dissemination and Implementation;Dose;E-learning;effective intervention;effective therapy;effectiveness/implementation trial;efficacious intervention;Elements;energy balance;Equity;evidence base;Evidence based intervention;Evidence based treatment;experience;Family;Family Process;Federally Qualified Health Center;Feedback;Focus Groups;follow-up;Fostering;Funding;Goals;Guidelines;hands-on learning;Health Personnel;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;healthy lifestyle;implementation intervention;implementation process;improved;indexing;Individual;innovation;Instruction;Intervention;intervention effect;Leadership;Learning;Market Research;Marketing;Medical;Methods;Monitor;multi-component intervention;National Institute of Child Health and Human Development;Non-Insulin-Dependent Diabetes Mellitus;Nonprofit Organizations;novel;Obesity;obesity in children;obesity treatment;Onset of illness;Parents;Participant;Phase;Pilot Projects;pilot test;pilot trial;Play;post intervention;Preventive service;primary care clinic;primary care setting;process evaluation;Professional Organizations;programs;Provider;psychosocial outcome;Public Health;Quality of life;Randomized;Recommendation;Research;Resources;response;Role;school based health center;Secure;simulation;skill acquisition;Small Business Innovation Research Grant;Societies;support tools;System;Technology;technology platform;Testing;Time;tool;Training;Translating;United States Preventative Services Task Force;Universities;usability;Washington;Weight;Weight maintenance regimen;Youth

PROJECT_TITLE: Leveraging Interactive Digital Technology to Increase Access to Family-Based Behavioral Treatment for Childhood Obesity