ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Genetics;Immunotherapy;Nanotechnology;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

PHR: Dense desmoplastic stroma is a fundamental characteristic of pancreatic ductal adenocarcinoma (PDAC) and comprises up to 80% of the tumor mass. While the strategy to deplete PDAC stroma has failed in clinical trials, normalization of the stroma to allow chemotherapy to kill the tumor cells in the “nest” could be a promising strategy for PDAC therapy. In this proposal, we will evaluate how the PCBP2 siRNA enhances the anti-tumor activity of chemotherapy and immunotherapy for PDAC.

PI_NAMEs: CHENG, KUN  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Affinity;angiogenesis;Animals;anti-PD-L1;Apoptotic;Binding;Binding Proteins;Biodistribution;Biological Assay;Cancer Etiology;cell transformation;Cells;Characteristics;chemotherapy;Cholesterol;Clinical Trials;Collagen Type I;Combined Modality Therapy;crosslink;Deposition;Desmoplastic;Drug Kinetics;effector T cell;Exhibits;Extracellular Matrix;Fibroblasts;Functional disorder;gemcitabine;Genes;Genetic Transcription;Goals;Hepatic Stellate Cell;Human;Immune Evasion;Immunotherapy;Implant;improved;In Vitro;in vitro activity;in vivo;Integrins;Intercellular Fluid;Link;migration;Morphology;mortality;mouse model;Mus;Myofibroblast;nanoparticle;Neoplasm Metastasis;neoplastic cell;NIH 3T3 Cells;novel;Nude Mice;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic stellate cell;Patients;PD-1/PD-L1;Penetration;Peptides;Pharmaceutical Preparations;Phenotype;Play;plectin;pressure;Production;programmed cell death ligand 1;Proliferating;Proteins;restraint;Role;Safety;Serum;Small Interfering RNA;Solid;Solubility;Specificity;Stress;Structure-Activity Relationship;Survival Rate;Therapeutic Index;Tissues;Toxicology;tumor;tumor growth;tumorigenesis;uptake;Vertebral column;X-Ray Crystallography;Xenograft procedure

PROJECT_TITLE: Normalizing PDAC stroma with PCBP2 siRNA nanoparticles to improve the antitumor activity of chemotherapy and immunotherapy

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;HIV/AIDS;Infectious Diseases;Nanotechnology;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Improved Nanoparticle Targeting of Tissue Myeloid Cells for HIV-1 Long-acting Pre-exposure Prophylaxis Relevance to Public Health The female genital tract and rectum are primary tissue sites of HIV transmission. This project develops nanoparticle-based strategies to achieve long-acting antiretroviral pre-exposure prophylaxis (PrEP) against mucosal HIV transmission in the female genital tract and rectum of a humanized mouse model. The proposed work provides the basis for future long-acting PrEP in humans.

PI_NAMEs: AMBROSE, ZANDREA ;GUMMULURU, SURYARAM ;REINHARD, BJOERN MARKUS (contact)

PROGRAM_OFFICER_NAME: DEY, BARNA

PROJECT_TERMS: Address;Adherence;Anti-Retroviral Agents;antiretroviral therapy;aqueous;Binding;Biomimetics;CD4 Positive T Lymphocytes;Cells;Clinical Research;Collection;Communities;copolymer;crosslink;Dendrimers;Dendritic Cells;design;Development;Diagnosis;Drug Delivery Systems;Drug Formulations;efficacy evaluation;emtricitabine;Encapsulated;Engineering;Ensure;Epidemic;Exhibits;extracellular vesicles;Fatigue;Federal Government;female reproductive tract;Formulation;Fumarates;Future;G(M3) Ganglioside;high risk;HIV;HIV-1;Human;humanized mouse;hydrophilicity;Hydrophobicity;improved;In Vitro;Incidence;Individual;Infection;Inflammatory Response;inhibitor;Injectable;Injections;Institution;Intake;Integrase;interest;interstitial;Length;Link;Lipids;Lymphoid Tissue;Macrophage;Maintenance;Mediating;Membrane;Micelles;mouse model;mucosal HIV infection;Mucositis;Mucous Membrane;Mus;Myeloid Cells;nanoparticle;nanopolymer;non-nucleoside reverse transcriptase inhibitors;nonhuman primate;Nucleosides;open label;Oral;Pharmaceutical Preparations;Physiological;pill;Play;Polymers;pre-exposure prophylaxis;prevent;Prevention strategy;Primary Prevention;Prodrugs;Property;Public Health;Randomized, Controlled Trials;Rectum;Reverse Transcriptase Inhibitors;Risk;Role;Sexual Transmission;Site;Surface;System;targeted delivery;technology platform;Temperature;Tenofovir;Testing;Time;Tissues;tool;transmission process;United States;United States Food and Drug Administration;United States National Institutes of Health;uptake;Vagina;Virus;Virus Diseases;Work


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative The human genome contains approximately 20,000 genes; in order to function properly, individual cells in the human body must precisely regulate the rate at which they use each of these genes through processes called transcriptional regulation. Segments of non-coding DNA outside of genes called regulatory elements mediate these processes, and differences in DNA sequence within regulatory elements can predispose individuals to developing particular traits or diseases. This project aims to build a comprehensive resource of regulatory elements in the human genome, including deep-learning models of their regulatory syntax, which will help researchers to understand how these regulatory elements function and to better design follow-up research to understand and treat disease.

PI_NAMEs: KUNDAJE, ANSHUL ;WENG, ZHIPING  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Algorithms;ATAC-seq;Atlases;Automobile Driving;base;Base Pairing;Benchmarking;Binding;Catalogs;cell type;Cells;ChIP-seq;Chromatin;Code;Collaborations;Collection;Communities;community building;Community Outreach;community setting;Computer Models;CRISPR/Cas technology;Data;Data Analyses;data analysis pipeline;data repository;Data Set;deep learning;deep learning model;deep sequencing;design;Development;Disease;DNA;DNA Sequence;Education and Outreach;Educational workshop;Elements;Epigenetic Process;epigenome;epigenomics;Exons;experimental study;follow-up;Functional disorder;Future;Genes;genome wide association study;Genomics;Histones;Human;Human BioMolecular Atlas Program;Human body;Human Genome;Human Genome Project;in silico;in vivo Model;Individual;International;Interruption;machine learning model;Maps;Mediating;Methods;model development;Modeling;Nematoda;novel;online resource;Online Systems;Organism;outreach;Pattern;Physiology;predictive modeling;Process;public repository;Quality Control;Registries;Regulatory Element;repository;Research;Research Personnel;Resolution;Resources;Role;Scheme;sequence learning;Signal Transduction;Specific qualifier value;syntax;Techniques;Technology;Testing;Time;Tissues;tool;Training;trait;Trans-Omics for Precision Medicine;transcription factor;Transcriptional Regulation;Untranslated RNA;Variant;Visualization;Work

PROJECT_TITLE: A Comprehensive Genomic Community Resource of Transcriptional Regulation


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Sleep Research

ORG_CITY: Boulder

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Public Health Relevance Insufficient sleep and circadian dysregulation cause, promote and exacerbate major medical health problems such as cardiovascular disease, obesity, diabetes, depression and respiratory disorders. The number of investigators being trained in transdisciplinary sleep and circadian research cannot keep pace with the accelerating health-care problems associated with insufficient sleep and circadian dysregulation. This training program will increase the number of researchers in the pipeline and facilitate the development of the next generation of scientific leaders; and thereby, this training program will ultimately contribute to knowledge of integrative physiological mechanisms and the treatment of disease that will advance the health and well-being of the public.

PI_NAMEs: WRIGHT, KENNETH P (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Circadian Rhythms;Sleep;Training

PROJECT_TITLE: Transdisciplinary Training in Sleep and Circadian Rhythms

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative: The incidence of WHO Grade II, diffuse lower grade gliomas (LGG) is about 15% of all gliomas; the assessment of disease aggressiveness is a long-standing challenge for treatment decision-making and surveillance strategies in WHO Grade II gliomas because of the tremendous variability in the course of the disease. It is thus essential to develop integrative decision models that leverage existing clinical and genomic measurements along with novel, diagnostic imaging-derived predictors to empower the physicians to assess disease course and effectively manage patients: for instance, highly aggressive LGGs are often candidates for aggressive surgical resection, which requires an accurate assessment of LGG aggressiveness. Such tools will also enable the patients and their caregivers to understand their individual disease, and enable them to collaborate more effectively with their oncologist to design appropriately tailored treatment strategies.

PI_NAMEs: KURTEK, SEBASTIAN ;RAO, ARVIND  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;Anxiety;Bioinformatics;Brain Neoplasms;Cancer Center;Caregivers;Characteristics;chemoradiation;chemotherapy;Clinical;Clinical Data;Collaborations;Complex;Data;Data Analyses;data integration;data quality;Data Set;Decision Making;Decision Modeling;density;design;Development;Diagnosis;Diagnostic Imaging;Diffuse;Disease;Disease Management;Disease Progression;Disparate;Dose;effective intervention;empowerment;Evaluation;Evolution;Excision;Eye;follow-up;Gene Expression;Genomics;Glioblastoma;Glioma;Goals;Heterogeneity;high risk;Image;Image Analysis;improved;Incidence;Individual;individualized medicine;insight;Interdisciplinary Study;Intuition;Magnetic Resonance Imaging;Malignant - descriptor;Measurement;Measures;Methods;Modality;Modeling;Monitor;Morphology;mouse model;Nature;neurosurgery;novel;Ohio;Oncologist;Operative Surgical Procedures;patient prognosis;Patient-Focused Outcomes;Patients;Performance;personalized medicine;Persons;Physicians;Population;Positioning Attribute;predictive modeling;Probability;Process;Prognosis;Publishing;Quality of life;Radiation therapy;radiological imaging;Recurrence;Research;Risk;risk prediction model;Scanning;Shapes;Source;spelling;Statistical Data Interpretation;Statistical Models;surveillance strategy;The Cancer Genome Atlas;Time;tool;Treatment outcome;treatment planning;treatment strategy;Trees;tumor;tumor heterogeneity;Uncertainty;Universities;University of Texas M D Anderson Cancer Center;Validation;Variant;Visual;Visualization;Visualization software;Work

PROJECT_TITLE: Synthesizing Image-derived Heterogeneity with Genomic measurements for Assessing Disease Aggressiveness in  Lower Grade Gliomas

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: OD

ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: HOUSTON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE: OVERALL COMPONENT The “Specific Pathogen Free 18 Baboon Research Resource” (SPF18BRR) is the only national research resource of adventitious virus free olive baboons (Papio anubis), their tissues and other biological materials, as well as the expertise to carry out research on this invaluable research animal. Scientist with NIH grants utilize virus free baboons to study the immunobiology of pig to baboon xenotransplantation, ways to develop or improve vaccines for SARS CoV-2, respiratory syncytial virus and pertussis, and to study the development of Alzheimer’s disease and related dementias. The goals of the SPF18BRR include provision of highly defined baboons and biomaterials to scientists, continued improvement of this animal resource, support to researchers requiring facilities and expertise to perform their studies, and training of the next generation of scientists, laboratory animal veterinarians, colony managers, and animal caregivers.

PI_NAMEs: HOPKINS, WILLIAM D;SIMMONS, JOE H. (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: 15 year old;3 year old;Address;Adult;Age;age group;Aging;Alzheimer's disease related dementia;animal breeding;Animal Experimentation;Animal Model;animal resource;Animals;Applied Research;Bacteremia;Bacterial Model;Biocompatible Materials;Biological;Biological Markers;Biology;Biomedical Research;Breeding;Caregivers;Cognition;cognitive testing;Communities;COVID-19 pneumonia;COVID-19 vaccine;Data;Data Management Resources;Databases;design;Development;Diabetes Mellitus;Discipline;DNA Methylation;Doctor of Philosophy;epigenetic clock;Epigenetic Process;Family suidae;Female;Foundations;Future;General Population;Genetic;genetic analysis;Genetic Engineering;genetic pedigree;Genetic Variation;genome sequencing;Genomics;germ free condition;Goals;Grant;Health Sciences;human disease;human model;Immunobiology;improved;Intramural Research Program;Laboratory Animals;male;Methods;Modeling;Monitor;Neurosciences;next generation;nonhuman primate;novel;offspring;Oklahoma;Papio;Papio anubis;pathogen;Pertussis;Pharmacologic Substance;Plasma;Primates;Privatization;Production;programs;Research;Research Contracts;Research Personnel;Research Project Grants;Resources;Respiratory syncytial virus;Scientist;Services;social;Students;System;Tissues;tool;Training;Training and Education;training opportunity;United States National Institutes of Health;Universities;Veterinarians;Virus;virus resource;web site;whole genome;Work;Xenograft procedure

PROJECT_TITLE: Specific Pathogen Free 18 Baboon Research Resource (SPF18BRR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-V(55)R]


PI_NAMEs: SIMMONS, JOE H. (contact)

PROJECT_TERMS: Alzheimer's disease related dementia;Animal Model;Animals;Area;Bacteremia;Bacterial Model;biobank;Biocompatible Materials;Biological;Biological Markers;Biology;Biomedical Research;Breeding;Caregivers;Communities;COVID-19 pneumonia;COVID-19 vaccine;Data;Data Management Resources;Databases;design;Development;Doctor of Philosophy;Family suidae;Female;Foundations;Future;General Population;Genetic;genetic analysis;Genetic Engineering;genetic pedigree;Genetic Variation;genome sequencing;germ free condition;Goals;Grant;human model;improved;Intramural Research Program;Lead;Modeling;Monitor;nonhuman primate;novel;offspring;Online Systems;Papio;Papio anubis;pathogen;Pertussis;Pharmacologic Substance;Play;Privatization;Production;programs;Research;Research Contracts;Research Personnel;Research Project Grants;Research Support;Resources;Respiratory syncytial virus;Role;SARS-CoV-2 infection;Scientist;searchable database;Services;Students;tool;Training and Education;United States National Institutes of Health;Veterinarians;Virus;web site;whole genome;Work;Xenograft procedure

PROJECT_TITLE: Specific Pathogen Free 18 Baboon Research Resource {(SPF18BRR): Resource Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-V]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cervical Cancer;Genetics;Human Genome;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Public Health Relevance/Narrative: Although HPV has been identified as a necessary cause of cervical cancer (CVC), which accounts for ~10% of cancer-related deaths in women globally, the vast majority of HPV-induced pre-cancer lesions eventually regress, suggesting that unknown intrinsic factor(s) associated with the genetic/genomic alterations of the high-risk population play a critical role in HPV-induced neoplasia progression and CVC development. Our recent studies suggest that the disrupted YAP1-LATS2 negative feedback loop serves as a previously unprecedented mechanism underlying the progression of HPV-induced pre-cancer lesions and CVC development. Research results derived from the proposed mechanistic and preclinical studies will recognize the disrupted YAP1-LATS2 feedback loop as a key driver of pre-cancer lesion progression, expand our knowledge on the CVC etiology, and provide new targets and strategies to improve the prevention and treatment of human pre-cancer lesions and invasive cancer.

PI_NAMEs: WANG, CHENG  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Achievement;Animal Model;Automobile Driving;base;Biological Markers;Cancer Etiology;cancer invasiveness;Cell Senescence Induction;Cells;Cervical;Cervical Cancer Screening;cervical carcinogenesis;Cervical Intraepithelial Neoplasia;Cervical Squamous Cell Carcinoma;Cervix Neoplasms;Clinical Trials;design;Development;Diagnosis;DNA Sequence Alteration;Epithelial Cells;Epithelium;Feedback;Gene Expression Profiling;Genes;Genetic;Genomics;Growth;high risk population;Homeostasis;HPV-High Risk;Human;Human papilloma virus infection;Human Papillomavirus;Human papillomavirus 16;Immunotherapeutic agent;improved;In Vitro;in vivo Model;Intrinsic factor;Knowledge;Laboratories;LATS2 gene;Lesion;Malignant - descriptor;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Molecular;mouse model;Mouse Strains;National Cancer Institute;Natural Immunity;Neoplasms;new technology;new therapeutic target;novel;novel therapeutics;Oncoproteins;Pap smear;Pathologic;Pathway interactions;pharmacologic;Phosphotransferases;Physiological;Play;preclinical study;premalignant;Prevention;Prevention strategy;public health relevance;receptor;Recurrence;Research;Role;role model;screening;senescence;Sensitivity and Specificity;Signal Pathway;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Solid;success;Survival Rate;System;Technology;Testing;Transgenic Animals;Transgenic Mice;Translating;tumor progression;United States;Viral;Woman;women's diagnosis;Women's mortality;Xenograft procedure

PROJECT_TITLE: Role of the YAP1-LATS2 negative feedback loop in cervical carcinogenesis

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pain Research;Substance Misuse;Tobacco

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative (Relevance to Public Health) Nicotine addiction and chronic pain are prevalent disorders that are highly comorbid and associated with negative affect, lost productivity, and significant health care costs. To address this co-morbidity, the proposed research will investigate dysregulation of brain ventral tegmental area – nucleus accumbens dopaminergic signaling and circuitry as a potential neurobiological mechanism for the association between chronic pain, pain-related negative affect, and nicotine use. The results will reveal essential causal mechanisms underlying chronic pain- associated abuse liability of nicotine and could contribute to the development of therapeutic interventions for patients with chronic pain and nicotine use disorder.

PI_NAMEs: BAGDAS, DENIZ  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: abuse liability;Address;Adult;Affective;Affective Symptoms;Anabolism;Anhedonia;Animals;Anxiety;anxiety-like behavior;Attenuated;Behavior;Behavioral;Binding;Biological Assay;Brain;career;Chronic intense pain;chronic pain;chronic pain patient;comorbidity;Corpus striatum structure;Data;Development;Dimensions;Disease;diversity and inclusion;Dopamine;Dopamine Antagonists;Dopamine D2 Receptor;dopaminergic neuron;DRD2 gene;drug reinforcement;Educational workshop;experience;extracellular;faculty mentor;Goals;Health Care Costs;Healthcare;high reward;Human;human data;in vivo;Individual;Infusion procedures;insight;Intake;Intervention;Intravenous;Investigation;Knowledge;Maintenance;Measures;Mediating;Mediation;Mental Depression;Mentors;Modeling;Mood Disorders;Morphine;Motivation;negative affect;Neurobehavioral Manifestations;neurobiological mechanism;Neurobiology;neurochemistry;neuronal circuitry;neuroregulation;Nicotine;Nicotine Dependence;nicotine exposure;nicotine self-administration;nicotine use;Nicotine Use Disorder;Nucleus Accumbens;optogenetics;Pain;Pain Measurement;pain sensitivity;Pathway interactions;Patients;Periodicity;personalized therapeutic;pharmacologic;Pre-Clinical Model;Principal Investigator;Productivity;professional atmosphere;programs;Psychiatry;Psychological reinforcement;Public Health;Rattus;Recording of previous events;Reporting;Research;reward circuitry;Rewards;Risk;Risk Factors;Scanning;Scientist;Self Administration;Sensory;Signal Transduction;Smoking;Substance abuse problem;symposium;Technical Expertise;therapeutic development;Therapeutic Intervention;Tobacco use;Training;vaping;Ventral Tegmental Area;Work

PROJECT_TITLE: Involvement of dopamine signaling in chronic pain-induced negative affective state and nicotine use comorbidity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-T(02)M]


NIH_SPENDING_CATS: Aging;Neurosciences

PROJECT_TERMS: 15 year old;3 year old;Adult;Age;age group;Aging;Alzheimer's disease related dementia;animal breeding;Animal Model;Animals;Applications Grants;Applied Research;Biological Markers;Biomedical Research;Breeding;Cerebrospinal Fluid;Cognition;cognitive testing;Diabetes Mellitus;DNA Methylation;Doctor of Philosophy;epigenetic clock;Epigenetic Process;Female;Foundations;Genetic;genome sequencing;germ free condition;Human;human disease;human model;improved;Intramural Research Program;male;Measures;model development;Neurosciences;nonhuman primate;offspring;Papio;Papio anubis;pathogen;Pharmacologic Substance;Plasma;Population Genetics;Primates;Privatization;Research;Research Contracts;Resources;social;System;Training;United States National Institutes of Health;Virus;whole genome

PROJECT_TITLE: Specific Pathogen Free 18 Baboon Research Resource (SPF18BRR): Applied Research


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Estrogen;Neurosciences;Substance Misuse;Women's Health Research

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Substance use disorder (SUD) is a costly and debilitating condition closely associated with poor decision making and elevated risk taking. Although significant strides have been made toward identifying the neural mechanisms by which substance use increases risk taking, the majority of this work is based on studies investigating the neural substrates of risk taking in males; consequently, we have an impoverished understanding of the neural substrates underlying risk taking in females, even before drug exposure. To begin to address this significant gap in knowledge, the proposed work seeks to elucidate the neurobiological mechanisms underlying hormone- dependent risk taking in females, the findings of which can then inform our understanding of how such mechanisms may be compromised after chronic substance use in females and lead to elevated risk taking.

PI_NAMEs: ORSINI, CAITLIN ANNE (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Ablation;Abstinence;Address;Agonist;Amygdaloid structure;Animal Model;Attenuated;Aversive Stimulus;Behavior;behavioral pharmacology;Cells;Chronic;Circulation;Clinical;Cocaine;Cognition;cost;Data;Decision Making;Dopamine D2 Receptor;Drug Exposure;drug relapse;Drug usage;efficacy evaluation;efficacy testing;Electrophysiology (science);ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogen Receptors;Exhibits;experimental study;Female;Fiber;Foundations;Genetic;Goals;Hormonal;Hormones;Hypersensitivity;Impairment;in vivo;Interneurons;Investigation;Knowledge;Lead;male;Mediating;Modeling;neural;neurobiological mechanism;neuromechanism;Neurons;optogenetics;Parvalbumins;Pharmaceutical Preparations;Photometry;Physiological;Positioning Attribute;Poverty;preclinical study;Process;programs;Punishment;Rattus;Receptor Activation;receptor function;Receptor Gene;Receptor Signaling;Regulation;Relapse;Reporting;Research;response;Rewards;Risk;Risk Taking;RNA Interference;Rodent Model;Role;selective expression;Sex Differences;small hairpin RNA;substance use;Substance Use Disorder;substance user;Testing;Translating;Work

PROJECT_TITLE: Investigation of the neurobiological mechanisms underlying estradiol-mediated risk aversion in females

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Wen, Li Project narrative We have found that gut bacteria V. dispar are significantly reduced in patients with type 1 diabetes (T1D) and these have immunoregulatory property when studied by mono-colonization of germ-free (GF) mice. The current application is designed to investigate the underlying mechanisms, which will help with the future therapeutic design for T1D and other autoimmune disorders.

PI_NAMEs: WEN, LI  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Acetates;Address;Animals;Autoimmune Diabetes;Autoimmune Diseases;Autoimmunity;Bacteria;Bacteriology;Biological Models;Cells;Collaborations;commensal bacteria;Consultations;Data;Dendritic Cells;Derivation procedure;design;diabetogenic;experience;Frequencies;Future;germ free condition;Germ-Free;gut bacteria;gut colonization;gut microbiota;Human;Immune;Immune system;Immune Tolerance;immunoregulation;improved;In Vitro;in vivo;Inbred NOD Mice;Insulin-Dependent Diabetes Mellitus;insulitis;Interleukin-10;Intestinal permeability;Lymphoid Tissue;Metabolism;Modeling;Mouse Strains;Mus;Neuropilin-1;novel;novel therapeutics;Oral;Oral cavity;oral microbial community;pathogenic bacteria;Patients;Peripheral;Prevotella;Property;Propionates;Reagent;receptor;Regulatory T-Lymphocyte;Role;Severities;Sjogren's Syndrome;stool sample;T-Lymphocyte;Testing;The Jackson Laboratory;Therapeutic;tool;Veillonella;Volatile Fatty Acids

PROJECT_TITLE: Identifying immunoregulatory gut bacteria in type 1 diabetes and autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Although gene therapy has shown great promise in a cat model of GM1-gangliosidosis by delaying symptom onset, reducing lysosomal storage in the brain and peripheral tissues, and prolonging lifespan, evaluation of its treatment efficacy in clinical trials is challenging due to the small and heterogeneous patient population as well as slow progression in the non-infantile patients. Recently, we discovered a pentasaccharide biomarker that was markedly elevated in biofluids from GM1-gangliosidosis patients and in the central nervous system (CNS) of the cat model and was reduced significantly in the CNS of the cat model in response to gene therapy, and thus the biomarker has potential as a pharmacodynamics/response biomarker. In this project, we will validate clinical assays for the biomarker in human urine, plasma, and CSF, and use these assays for assessing the efficacy of gene therapy in a clinical trial.

PI_NAMEs: JIANG, XUNTIAN  (contact)

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Acceleration;Affect;Aftercare;analytical method;Assessment tool;beta-Galactosidase;Biological Assay;Biological Markers;biomarker validation;Bone structure;Brain;Central Nervous System;Cerebrospinal Fluid;Cessation of life;Clinical;clinical efficacy;clinical predictors;Clinical Trials;Data;DCNU;Defect;Diagnosis;Disease;Disease Progression;drug development;effective therapy;efficacy evaluation;enzyme activity;Evaluation;Exhibits;extend lifespan;Felis catus;Foundations;Galactose;Ganglioside GM1;Gangliosidosis GM1;gene therapy;gene therapy clinical trial;Gene therapy trial;Genetic Diseases;GLB1 gene;Glycoconjugates;Glycopeptides;Goals;Human;Impaired cognition;Keratan Sulfate;life span;Liquid Chromatography;Liver;longitudinal analysis;Measures;Methods;Modeling;Motor;Mutation;Natural History;Nerve Degeneration;Neurologic Symptoms;Normal Range;Oligosaccharides;Organ;Outcome Measure;patient population;Patients;Peripheral;Pharmacodynamics;Phase I/II Clinical Trial;Phase I/II Trial;Plasma;potential biomarker;Pre-Clinical Model;premature;Reference Values;Reproducibility;response;response biomarker;restoration;Sampling;Specificity;Spleen;symptom treatment;Symptoms;tandem mass spectrometry;Tissues;Treatment Effectiveness;Treatment Efficacy;Urine;Validation;Viral;Viral Genes;Visual;Work

PROJECT_TITLE: Validation of analytical methods for quantification of a pentasaccharide biomarker in efficacy assessment of AVV treatment for GM1 gangliosidosis

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Microbiome;Prevention

ORG_CITY: WASHINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health, because little is known about how nasal microbiome could affect natural-occurring immune protections in the nasal cavity of adults, which can affect the adult population’s risks for respiratory viruses such as coronaviruses, influenza, and rhinovirus. By studying nasal microbiome and these important types of immune response, this project will build new knowledge on the natural immune protection in adults against respiratory viral infections. Therefore, the proposed research is relevant to the NIH mission to better understand and prevent infectious diseases, including those caused by influenza, coronaviruses (including SARS-CoV-2), and other respiratory viruses.

PI_NAMEs: LIU, CINDY  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Acute;Address;Adult;Affect;airway epithelium;Bacteria;Child;Chronic;Coculture Techniques;Communicable Diseases;Communities;Coronavirus;cytokine;Disease;disorder risk;Environment;Epidemiology;Epithelium;experimental study;FluMist;Goals;Home;Homeostasis;host-microbe interactions;Immune;Immune response;Immunology;improved;In Vitro;Infant;Infectious Diseases Research;Inflammation;Inflammatory;Influenza;Influenza A virus;innovation;Interferons;Knowledge;Longitudinal Studies;Lower respiratory tract structure;microbiome;microbiome composition;Mission;Modeling;Mucous body substance;Mucous Membrane;Nasal cavity;nasal microbiome;Nose;novel strategies;Outcome;Population;Predisposition;prevent;Property;Public Health;Research;respiratory microbiome;Respiratory System;Respiratory Tract Infections;respiratory virus;response;Rest;Rhinovirus;Risk;Risk Reduction;Sampling;Testing;Time;United States National Institutes of Health;Upper respiratory tract;Vaccination;Variant;Viral;Viral Respiratory Tract Infection;virology;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Influence of the nasal microbiome on host susceptibility and response to respiratory viruses

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Biomedical engineering students require early, practical experience to develop the technical skills, knowledge of regulatory pathways, and training in teamwork necessary to solve unmet clinical needs as part of the biomedical engineering workforce. Our goal is to develop a core, sophomore-level, medical devices course in which students simulate the engineering teams found in industry in order to build workplace-ready skills. To accomplish this goal, we will implement innovative, scalable instructional methods that we expect will enhance students' professional engineering identities and develop their technical and professional skills, leading to enhanced retention and representation in the biomedical engineering workforce.

PI_NAMEs: ROONEY, SARAH ILKHANIPOUR (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Accounting;Bachelor's Degree;Biomedical Engineering;broadening participation research;Businesses;career;Career Choice;career preparation;Classification;Clinical;clinical research site;college;Competence;computer generated;Computer-Aided Design;Delaware;design;Development;Device or Instrument Development;Devices;Dimensions;Dissection;Education;Educational Curriculum;Engineering;engineering design;Ethics;experience;Focus Groups;Future;Goals;Growth;Immersion;Industry;innovation;Instruction;Intervention;Interview;Knowledge;Learning;Learning Module;Maps;Marketing;Measures;Medical Device;Medical Device Designs;Medical Technology;men;Methods;Modeling;Needs Assessment;new product development;novel;Occupations;Outcome;Performance;Phase;Population;Process;professional students;programs;Recommendation;Records;Regulatory Affairs;Regulatory Pathway;Role;scale up;skills;Specialist;Specific qualifier value;stakeholder perspectives;statistics;Students;success;Surveys;Systems Development;Technical Expertise;Technology;Time;Training;Translating;undergraduate student;Underrepresented Populations;United States;Universities;Voice;Woman;Work

PROJECT_TITLE: Simulating Workforce Design Teams in Biomedical Engineering Education


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: NARRATIVE Misregulation of human cell division can lead to uncontrolled cellular proliferation and carcinogenesis. The repertoire of enzymes and regulatory mechanisms that are necessary to carry out cell division with high fidelity are not completely understood. This proposal addresses this deficiency and will define the function of enzymes that are critical to cell division, which will increase our understanding of human cell proliferation and aid the development of novel therapeutics for proliferative diseases like cancer.

PI_NAMEs: TORRES, JORGE  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Aneuploidy;Biochemistry;Biology;cancer type;carcinogenesis;Cell division;Cell Proliferation;Cells;Cellular biology;Centrosome;Chemicals;Chromosomal Instability;Complex;Computational Biology;Cytokinesis;Development;Disease;Ensure;Enzymes;Event;Genetic Screening;Homeostasis;Human;inhibitor;interdisciplinary approach;Malignant Neoplasms;Microtubule-Associated Proteins;Microtubules;Mitotic;Mitotic spindle;Molecular Biology;Molecular Probes;novel;novel therapeutics;Post-Translational Protein Processing;protein complex;protein function;protein protein interaction;Proteins;Proteomics;research study;Role;segregation;Sister Chromatid;Therapeutic

PROJECT_TITLE: Investigating the Cell Division Machinery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;HIV/AIDS;Infectious Diseases;Nanotechnology;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_CITY: Seattle

ORG_NAME: PATH

ORG_STATE: WA

PHR: PROJECT NARRATIVE Overall, this five-year project intends to demonstrate proof-of-concept of microarray patch technology for delivering long-acting antiretroviral drugs for pediatric HIV treatment. As a painless, home-administered, long-acting drug delivery system, microarray patches could fulfill an unmet need for pediatric patients infected with HIV and improve health outcomes.

PI_NAMEs: CHOY, ROBERT KWAI MING (contact);DONNELLY, RYAN

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: Acceleration;Adherence;Adolescent;Age;age group;Anatomy;Animal Model;Anti-Retroviral Agents;anti-viral efficacy;antiretroviral therapy;aqueous;Bandage;Binding;Caregivers;Characteristics;Child;Childhood;clinically relevant;design;Development;Dosage Forms;Dose;drug action;Drug Delivery Systems;drug development;Drug Kinetics;efficacy study;engineering design;Ensure;Family suidae;Formulation;Geometry;Hazard Identification;Health;Height;HIV;Home;Hour;Human;Implant;improved;In Vitro;in vivo;Infant;Injectable;International;Interview;Intramuscular Injections;Kinetics;Macaca;Maintenance;manufacture;Measures;meter;Molds;nano;nanoparticle drug;Needles;Neonatal;non-drug;nonhuman primate;novel;Oral;Outcome;Output;Painless;Parents;pediatric human immunodeficiency virus;pediatric human immunodeficiency virus infection;pediatric patients;Penetration;Performance;Pharmaceutical Preparations;pharmacokinetic model;Phase;Physiological;Plasma;Polymers;pre-clinical;Process;product development;prototype;Rattus;Regimen;Risk;RNA-Directed DNA Polymerase;Route;Safety;Sampling;service delivery;simian human immunodeficiency virus;Skin;Solid;Standardization;Stratum corneum;Suspensions;Target Populations;Technology;Time;user centered design;Vaccines;Viral;Virus;Work

PROJECT_TITLE: MAPs for Peds: Development of a Microarray Patch for Delivery of Long-Acting Antiretrovirals for Treatment of Pediatric  HIV Infection


NIH_SPENDING_CATS: Cancer

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The NCI Research Specialist R50 Grant will support the development of continued research career opportunities for exceptional clinician scientists, such as Dr. Salma Jabbour, who have demonstrated and plan to continue leadership in the NCI clinical trials networks, development of institutional clinical trials, and national service to NCI clinical trials. Dr. Jabbour is a clinical trial and institutional leader in the oversight and implementation of institutional and national clinical trials whose work has focused on combination therapies with radiation as well as the mentorship and development of early career investigators.

PI_NAMEs: JABBOUR, SALMA  (contact)

PROGRAM_OFFICER_NAME: TAWAB-AMIRI, ABDUL

PROJECT_TERMS: American College of Radiology Imaging Network;Award;cancer care;cancer clinical trial;Cancer Institute of New Jersey;Cancer Therapy Evaluation Program;career;Caring;Clinical;Clinical Trials;Clinical Trials Network;Collaborations;Combined Modality Therapy;Complex;design;Development;Early Therapeutic-Clinical Trials Network;Eastern Cooperative Oncology Group;Funding;gastrointestinal;Grant;Human;innovation;Institution;Interest Group;Leadership;Malignant Neoplasms;Mentors;Mentorship;novel;Oncology;Patient Care;Patients;Physicians;Play;programs;Protocols documentation;Radiation;Research;Research Personnel;Role;Scientist;Seasons;Services;Specialist;Time;Work

PROJECT_TITLE: Dr. Salma Jabbour’s NCI Research Specialist (Clinician Scientist) Award (R50)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Wound Healing and Care

ORG_CITY: IRVINE

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Narrative In this application we develop iFLAME, a fast, large area multiphoton exoscope optimized for in vivo label-free imaging of immune cell populations and their dynamics in human skin. We validate iFLAME performance by demonstrating its ability to discriminate immune cells in vivo and develop quantitative morphological, metabolic and dynamic imaging endpoints to assess immune infiltrates in human skin during the wound healing process. Completion of these studies will establish the practical utility and value of iFLAME as a non-invasive clinical research tool for monitoring immune responses at the cellular level in human skin.

PI_NAMEs: BALU, MIHAELA  (contact);GANESAN, ANAND K

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Affect;Algorithms;Area;Atopic Dermatitis;Autoimmune;Autoimmune Diseases;Behavior;Benchmarking;Biological Markers;Cells;Cellular Assay;cellular imaging;Cellular Morphology;Chemicals;Clinical;clinical imaging;Clinical Research;cofactor;Collagen;Compensation;Computing Methodologies;contrast imaging;convolutional neural network;Cutaneous;Data;data acquisition;Dedications;Dermal;Dermis;design;Detection;detection sensitivity;Development;Devices;Elastin;Epithelium;experience;Fiber;Fluorescence;fluorophore;Funding;Generations;Genetic Transcription;Goals;Grant;healing;Histologic;Human;human imaging;Image;Imaging Device;imaging platform;Immune;immune cell infiltrate;immune imaging;Immune response;Immunologic Monitoring;improved;In Situ;in vivo;Infiltration;instrument;intravital imaging;Keratin;Label;Lasers;Location;Macrophage;Malignant Neoplasms;Measurement;Melanins;Metabolic;metabolic imaging;Methods;Microscope;Microscopic;microscopic imaging;Modality;Molecular;Morphology;Motility;mouse model;Movement;multi-photon;multiphoton microscopy;NADH;operation;Optical Methods;Optics;Organ;Organ Transplantation;Patients;Performance;Physiologic pulse;Play;Population;portability;Process;protein biomarkers;prototype;Reporter;Research;Resolution;Scanning;second harmonic;Signal Transduction;Skin;skin disorder;Source;Specificity;Speed;standard of care;Structure;Techniques;Technology;technology development;Therapeutic;Time;Tissues;tool;treatment response;tumor-immune system interactions;two-photon;Visualization;Work;wound;wound care;wound healing;wound treatment

PROJECT_TITLE: Development of a fast scanning, extended field-of-view multiphoton microscope for clinical skin imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-J(03)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

PHR: PROJECT NARRATIVE Latino individuals, the fastest growing ethnic minority population in the United States, have a higher prevalence of type 2 diabetes and diabetes-related complications, and are more likely to report inconsistent use of diabetes medications than non-Hispanic White individuals. The proposed project will develop and test an interactive text message-based tool tailored to address barriers to taking diabetes medications that are relevant to Latino adults. If found feasible, acceptable, and usable, this intervention could serve as a scalable tool to improve diabetes management and reduce diabetes-related complications among Latino adults in the United States.

PI_NAMEs: SEIGLIE, JACQUELINE ANNE (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: Address;Adherence;Adult;Behavior Therapy;Biometry;career;Clinical;Clinical Trials;clinically relevant;Communication;comparison control;compliance behavior;Complications of Diabetes Mellitus;Conduct Clinical Trials;cost;Data;diabetes management;Diabetes Mellitus;diabetes self-management;digital health;Disparity;disparity reduction;Education;Educational Materials;effectiveness/implementation trial;Endocrinologist;Epidemiology;ethnic minority;ethnic minority population;Evidence based intervention;Feedback;Focus Groups;Glycosylated hemoglobin A;Goals;health communication;Health Technology;High Prevalence;improved;improved outcome;Individual;innovation;Insulin;interest;Intervention;intervention refinement;Interview;Language;Latin America;Latino;Latino Population;live text;medication compliance;medication nonadherence;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;mHealth;mhealth interventions;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Outcome;Participant;patient engagement;patient oriented;patient portal;Patient Self-Report;Patients;Perception;Pharmaceutical Preparations;Physicians;Population;Prevalence;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Research Training;response;retention rate;secondary outcome;Self Care;Self Efficacy;social disparities;Spanish;standard of care;Strategic Planning;System;Testing;Text Messaging;Therapeutic;therapy development;Time;tool;Training;two way texting;United States;usability;Work

PROJECT_TITLE: REACH-Es: Adapting a digital health tool to improve diabetes medication adherence among Latino adults

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Prevention;Substance Misuse

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE People living with HIV (PLWH) experience higher rates of stress-related conditions (e.g., substance use, depression, systemic inflammation), which puts PLWH at greater risk for accelerated aging-related chronic diseases (e.g., heart diseases, cancers, metabolic disorders). The brain’s central executive network plays a key role in exerting self-control, reappraising stressful stimuli, and managing unpleasant thoughts. This project will test whether PLWH who have greater functional connectivity in the brain’s central executive network are less likely to experience depression, substance use, and consequent systemic inflammation.

PI_NAMEs: SCHROCK, JOSHUA MATTHEW (contact)

PROJECT_TERMS: Adherence;Age;age acceleration;aging related;aging related disease;antiretroviral therapy;assigned male at birth;Bisexual;Brain;Cardiovascular Diseases;career;Caring;Chronic;Chronic Disease;Clinical;Clinical Psychology;cognitive training;Cohort Studies;comorbidity;depressive symptoms;Development;disorder prevention;Emotions;Enrollment;experience;fall risk;follow-up;Funding;Gays;gender minority youth;Goals;Grant;Health;Heart Diseases;HIV;improved;Individual;Inflammation;Intervention;Life;Literature;Longitudinal cohort study;Malignant Neoplasms;Manuscripts;Mediating;Meditation;men;Mental Depression;Mental Health;Mentors;Metabolic Diseases;Modeling;neuroimaging;Neuroimmune;neuroimmunology;neuroregulation;Neurosciences;nonbinary;novel;Outcome;Pathogenesis;Pattern;Persons;Play;Predisposition;prevent;Prevention;programs;reduced substance use;Research;Research Personnel;Rest;Risk;Risk Factors;Sampling;Self-control as a personality trait;sexual minority youth;skills;Stimulus;Stress;substance use;systemic inflammatory response;Testing;therapy adherence;Thinking;Training;transgender women;Visit;Writing;young adult

PROJECT_TITLE: Integrated neuroimmune model of problematic substance use and depression in people living with HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Aging;Bioengineering;Cardiovascular;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Diseases of the aorta (the largest artery in the body) are increasingly responsible for death and disability in the United States, but fortunately life-saving surgical procedures are available. Such surgeries need to be timed appropriately, however, because either premature or delayed surgery can increase risk to the patient. This research is novel and important for we will develop and validate a new computer model-based approach that will help surgeons to optimally time surgery, thus improving patient care.

PI_NAMEs: ASSI, ROLAND  (contact);BELLINI, CHIARA ;KARNIADAKIS, GEORGE

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Acute;Adherence;Affect;Aging;Algorithms;Aneurysm;Aorta;Aortic Diseases;Arteries;Attention;Basic Science;biomechanical model;Biomechanics;Biomedical Engineering;biophysical model;Blood Vessels;Body Surface Area;Caring;Cessation of life;Clinical;clinical care;Clinical Data;clinical imaging;Clinical Management;Clinical Research;Collagen;Collection;Computer Models;Data;Data Analyses;Data Set;Databases;design;Diameter;disability;Disease;Dissection;Distal;DNA Sequence Alteration;drug efficacy;Elastic Fiber;Emergency Situation;Event;experience;falls;Female;Foundations;Frequencies;Gene Modified;Generations;generative adversarial network;Genetic;Genetic Predisposition to Disease;Goals;Grant;Growth;Guidelines;Human;human data;Hypertension;Image;improved;in silico;in vivo;Incidence;Individual;innovation;Intervention;Knowledge;Learning;Lesion;Life;Machine Learning;machine learning algorithm;machine learning prediction algorithm;male;mechanotransduction;Medical Genetics;Medical Imaging;Medical Surveillance;Medicine;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Natural History;neural;neural network;Neural Network Simulation;next generation;novel;Older Population;Operative Surgical Procedures;Outcome;Paper;Pathology;Patient Care;Patients;Persons;Pharmacotherapy;Phenocopy;Physicians;Physics;Postdoctoral Fellow;predictive modeling;Predisposition;premature;Prevalence;Prognosis;prophylactic;prospective;Prosthesis;Regulation;repaired;Research;Resolution;Risk;Risk Factors;risk prediction;Rupture;Sampling;Scientist;sex;Shapes;Signal Transduction;sobriety;Students;Surgeon;Syndrome;synthetic data;Techniques;Testing;Thoracic aorta;Thoracic Aortic Aneurysm;Time;Tissues;tool;Training;training data;Uncertainty;United States;Work

PROJECT_TITLE: Neural Operator Learning to Predict Aneurysmal Growth and Outcomes

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Epilepsy;Neurodegenerative;Neurosciences;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative The goal of our project is to discover why adults 65 and older with new-onset epilepsy (late-onset epilepsy) are 2 to 3 times more likely to develop dementia and stroke than their peers without epilepsy. Understanding the role of vascular risk factors in the association of late-onset epilepsy with dementia and stroke will provide guidance for future strategies to mitigate the risks for these secondary neurological outcomes.

PI_NAMEs: CHOI, HYUNMI  (contact);GUTIERREZ, JOSE ;THACKER, EVAN LLOYD

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Address;Adult;Affect;age group;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;anti-epileptic agents;Awareness;Benefits and Risks;Biological;Blood Vessels;brain health;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Caring;Cerebrovascular Trauma;Classification;Clinical;clinical care;clinical practice;Clinical Trials;Cognitive;cognitive ability;cohort;Cohort Studies;Data;data harmonization;Dementia;dementia risk;Diabetes Mellitus;Diagnosis;Epilepsy;ethnic diversity;Ethnic Origin;Event;executive function;experience;Funding;Future;Goals;high risk;human old age (65+);Hyperlipidemia;Hypertension;Impaired cognition;improved;Incidence;Individual;individualized medicine;innovation;Institute of Medicine (U.S.);Intervention;Intervention Trial;Knowledge;Magnetic Resonance Imaging;Measures;Memory;Modeling;models and simulation;Nervous System Disorder;Neurologic;Neurological outcome;novel;older adult;Participant;Patients;peer;Persons;Play;Population;post stroke;Practice Guidelines;preservation;prevent;Prevention Guidelines;Prevention strategy;Prospective, cohort study;Race;Reduce health disparities;Reporting;Research;Resources;Risk;Risk Assessment;Risk Estimate;Risk Marker;risk mitigation;risk prediction;risk prediction model;Risk Reduction;Role;Seizures;sex;Sex Differences;simulation;Smoking;Specific qualifier value;Stroke;Testing;Treatment Factor;treatment strategy;United States National Institutes of Health;Vascular Diseases;vascular risk factor;Work

PROJECT_TITLE: Effects of vascular risk factors on risk for dementia and stroke after late-onset epilepsy (EpilepsyCOG)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(90)]


NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Our laboratory has identified and characterized a family of evolutionarily-conserved endocytic adaptor proteins called epsins, which have crucial roles in coordinating endocytosis and signal transduction. In this project, we will use unique transgenic knock-out mouse strains and cell culture models to investigate the role of epsins in regulating vascular smooth muscle cell (VSMC) homeostasis and phenotypic switching in health and disease. The proposed experiments are expected to identify molecular targets that will provide the foundation for the development of novel therapeutics to treat atherosclerosis and other vascular diseases that represent a leading cause of death worldwide and remain highly-relevant to the mission of the NIH.

PI_NAMEs: CHEN, HONG  (contact);CHEN, YABING

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Adaptor Signaling Protein;Aorta;Apolipoprotein E;Area;Arterial Fatty Streak;arterial stiffness;Arteries;atherogenesis;Atherosclerosis;Attenuated;Biochemical;Blood Vessels;calcification;Cardiovascular Diseases;Cause of Death;Cd68;Cell Culture Techniques;Cell Physiology;cell regeneration;Cells;Cholesterol;Chronic;Complement;Coronary heart disease;Data;Development;Diet;Disease;Endocytosis;Endothelial Cells;endothelial dysfunction;endothelial repair;Endothelium;epsin;epsin 1;experimental study;Family;Foam Cells;Fortification;Foundations;Gene Expression;Genetic Markers;Goals;Health;Heart Diseases;Homeostasis;Human;Immune;In Vitro;in vitro Model;Infiltration;Inflammation;Inflammatory;injured;injury and repair;innovation;insight;Knockout Mice;Laboratories;Legal patent;Lesion;Light;Mediating;Mesenchymal;Mission;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;Mouse Strains;multidisciplinary;Mus;Mutant Strains Mice;Myeloid Cells;nanoparticle;nanoparticle delivery;next generation;novel;novel therapeutics;Osteogenesis;osteogenic;overexpression;oxidized low density lipoprotein;Pathogenesis;Pathologic;Phenotype;Play;pluripotency;prevent;Process;Proteins;PTPRC gene;Reagent;Repression;Resolution;response;Role;Signal Pathway;Signal Transduction;siRNA delivery;Small Interfering RNA;Smooth Muscle Myocytes;Source;Stimulus;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Time;tool;transcription factor;transcriptome sequencing;transdifferentiation;Transgenic Organisms;translational potential;Ubiquitination;United States National Institutes of Health;Vascular Diseases;vascular inflammation;Vascular Smooth Muscle;Work

PROJECT_TITLE: Molecular Mechanisms Governing Vascular Cell Function and Phenotype in Health and Disease

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Complementary and Integrative Health;Natural Products;Neurosciences;Pain Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative The goal of this project is to develop a physiologically relevant in vitro assay that will allow for medium- to high- throughput screening of natural product libraries with the goal to identify novel compounds that selectively inhibit pain-sensing neurons with potential to be effective analgesics.

PI_NAMEs: CLARKE, WILLIAM P (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Adult;Adverse effects;Affect;Afferent Neurons;Analgesics;antinociception;assay development;base;Biological;Biological Assay;Calcitonin Gene-Related Peptide;Calcitonin-Gene Related Peptide Receptor;Calcium;cell type;Cells;Chemical Structure;Chemicals;Chemistry;Coculture Techniques;Collaborations;counterscreen;daily pain;density;Development;Developmental Therapeutics Program;Drug Screening;Effectiveness;Engineering;experience;Fluorescence;Fractionation;Genetic Engineering;Goals;Grant;high throughput screening;Human;Human Resources;in vitro Assay;in vivo;in vivo evaluation;Inflammatory;inflammatory pain;innovation;interest;Libraries;Life;Ligands;Local Anesthetics;Measurement;Mediating;Medical;Methods;Monitor;Motor;Motor Neurons;National Center for Complementary and Integrative Health;Natural Compound;Natural Products;Neurons;Neuropeptides;Nociceptors;Non-Steroidal Anti-Inflammatory Agents;novel;Opioid;Pain;pain inhibition;pain model;Peripheral;peripheral pain;Persons;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Process;Rattus;Reporting;research clinical testing;response;screening;Screening procedure;Sensory;Sensory Ganglia;Specific qualifier value;Specificity;Spinal Ganglia;Stimulus;System;Testing;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Development of a phenotypic screening assay for novel compounds that inhibit peripheral pain-sensing neurons

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE Herpesviruses are important human pathogens for which no effective long-term remedies are available. A unique and critical component of the virus is the portal vertex through which the viral genome is packaged into the viral capsid as part of the process to assemble new virions. Our study aims to understand the organization and functions of the proteins that make up the portal vertex, and their interactions with each other, the capsid, and the viral DNA. This knowledge will form a framework for developing therapeutic molecules that are specific to the virus, effective in preventing infection, and target essential structures that are not amenable to changing for escaping the therapeutic effects.

PI_NAMEs: CONWAY, JAMES F. (contact);HOMA, FREDERICK L

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: adenovirus penton protein;Architecture;Binding;Biochemical;Capsid;Cell Separation;Complex;Cryoelectron Microscopy;Data;Defect;density;design;Development;DNA Packaging;Genes;Genetic;Genome;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;human pathogen;Image;In Situ;Infection;Infection prevention;innovation;insight;Knowledge;Laboratories;Length;Morphology;mutant;Positioning Attribute;prevent;Process;protein function;Proteins;Publishing;Reaction;reconstruction;recruit;Research;Role;Simplexvirus;Site;structural biology;Structure;Techniques;terminase;Testing;Therapeutic;Therapeutic Effect;Viral;viral DNA;Viral Genes;Viral Genome;Viral Packaging;Viral Proteins;Virion;virology;Virus;Virus Replication;Visualization

PROJECT_TITLE: Structure and function of the portal vertex on the herpes simplex virus capsid

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-W(02)M]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Sleep Research

ORG_DEPT: GENETICS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Sleep disorders have a major clinical and economic impact in the U.S., with 10-15% of the U.S. population suffering from chronic insomnia. Molecular genetic studies that began in Drosophila have already allowed mutant orthologs of Period proteins, casein kinase 1, and Cryptochromes to be connected to certain inborn errors of human sleep including familial forms of advanced sleep phase and delayed sleep phase disorders. Given the impact of these earlier contributions, we believe our proposed genetic, cellular, and biochemical studies of Drosophila will continue to provide tools and discoveries relevant to our understanding of human sleep.

PI_NAMEs: YOUNG, MICHAEL WARREN (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Affect;Binding;Biochemical;biological adaptation to stress;Biological Assay;biophysical properties;Blood - brain barrier anatomy;blood-brain barrier function;Brain;casein kinase I;Chronic;Chronic Insomnia;circadian pacemaker;Clinical;comparative;cryptochrome;Desire for food;Disease;Drosophila genus;economic impact;Exposure to;fly;Food;gene product;Genes;Genetic;Genetic Screening;Genetic study;Hereditary Disease;Human;human error;Hunger;Ion Exchange;life span;Longevity;Maps;Measurement;Mental Health;Metabolism;Molecular;Molecular Genetics;Monitor;Morphology;Motor Activity;mutant;Mutation;Nervous System Physiology;Neuroglia;neuronal circuitry;novel;Orthologous Gene;Pathway interactions;Permeability;Phase;physical conditioning;Population;Proteins;Recovery;response;restoration;Role;Siblings;Sleep;sleep behavior;Sleep Deprivation;Sleep Disorders;Social isolation;Stress;stressor;temporal measurement;Time;Tissues;tool;transcriptome sequencing;Wakefulness

PROJECT_TITLE: Molecular pathways connecting sleep, stress, metabolism and longevity


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Rare Diseases

ORG_CITY: BOSTON

PHR: PROJECT NARRATIVE Mitochondrial Disorders are rare and often devasting disorders of the brain, muscle and other organs for which there are no proven laboratory markers for disease severity or progression and no proven treatments. They are difficult to study because both nuclear and mitochondrial genes are used to make mitochondria. We have modified conventional methods used to study nuclear genes to enable us to study both nuclear gene function and mitochondrial gene changes to improve understanding of Mitochondrial Disorders arise and, eventually, how to better diagnose, track, and treat them.

PI_NAMEs: WALKER, MELISSA ANNE (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Affect;American;Animal Model;Animals;B-Lymphocytes;Biogenesis;Biology;Biopsy Specimen;Blood;Blood Cells;Blood specimen;Brain;Brain Diseases;career;Cell division;Cell Line;cell type;Cells;Cellular biology;Cellular Structures;Childhood;Clinic;Clinical;clinical examination;cohort;Collaborations;collected works;Data;developmental disease;Diagnosis;Diagnostic;Disease;Disease Progression;DNA;experimental study;Failure;Family;FDA approved;functional status;Funding;gene function;Genes;Genetic;Genetic Diseases;Genome;Genomics;Goals;heteroplasmy;Human;improved;Individual;inhibitor;innovation;Institutional Review Boards;K-Series Research Career Programs;Knowledge;Laboratory Markers;Lesion;Leukocytes;Link;Measurement;Measures;MELAS Syndrome;Membrane Potentials;Mentors;Methods;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial membrane;molecular pathology;monocyte;Muscle;Mutation;Myopathy;Neurodegenerative Disorders;neuroimaging;novel strategies;Nuclear;Operative Surgical Procedures;Organ;Oxidative Phosphorylation;Pain;Pathogenesis;Patients;Pattern;Performance;Persons;Phenotype;Positioning Attribute;Procedures;Process;Production;prognostication;prospective;Rare Diseases;Research;Sampling;segregation;Severity of illness;single cell genomics;Skeletal Muscle;skills;success;Symptoms;T-Cell Activation;T-Lymphocyte;Techniques;Technology;Testing;theories;Time;Tissues;Training Support;trait;Whole Blood;Work

PROJECT_TITLE: Dual Genome Omics: Adapting Genomics Techniques to Reveal Molecular Pathology in Mitochondrial Disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Infectious Diseases;Nutrition

ORG_CITY: Chicago

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Infections caused by Staphylococcus aureus are a major public health concern due to their high incidence and significant morbidity and mortality. Increases in antibiotic resistance, coupled with an incomplete understanding of the immunological response to the bacterium, have limited available treatment strategies. This proposal will investigate novel mechanisms by which S. aureus evades the immune response and adapts to nutrient restriction in the host with goals of improving our ability to rationally design anti-S. aureus therapeutics that cripple bacterial replication and promote robust immune responses during infection.

PI_NAMEs: ALONZO, FRANCIS  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: ADP ribosylation;Affect;Anabolism;Antibiotic Resistance;Antioxidants;Bacteria;bacterial metabolism;biological adaptation to stress;Bypass;cell killing;cofactor;Communities;Coupled;cytokine;Dependence;Development;Disparate;Environment;Enzymes;fitness;Generations;Glycine;Goals;Grant;Growth;Homeostasis;Immune;immune activation;Immune Evasion;Immune response;Immunity;improved;in vivo;Incidence;Infection;Infectious Skin Diseases;Innate Immune Response;intraperitoneal;Knowledge;Ligands;Ligase;Link;Lipids;Luciferases;Macrophage;Macrophage Activation;Mechanics;Mediating;Mediator;Metabolic;Metabolic Pathway;Metabolism;Mixed Function Oxygenases;Morbidity - disease rate;mortality;Multienzyme Complexes;Mus;mutant;NADPH Dehydrogenase;Natural Immunity;new therapeutic target;Nitrogen;Nosocomial Infections;novel;novel therapeutics;novel vaccines;Nutrient;Nutritional;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Oxygen;pathogen;Pathway interactions;Peptides;Prevalence;prevent;Process;Production;Proteins;Public Health;Pyruvate Dehydrogenase Complex;rational design;recruit;Regulation;release factor;Resistance;response;Role;Sepsis;Sirtuins;Site;Skin;Staphylococcus aureus;Staphylococcus aureus infection;System;Systemic infection;Therapeutic;Thioctic Acid;Tissues;TLR1 gene;treatment strategy;United States;Virulence;Virulent;Work

PROJECT_TITLE: Staphylococcus aureus Survival During Nutrient Restriction and Suppression of Host Immunity.

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Cancer;Liver Disease;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Liver cancer, a gastrointestinal cancer of poor prognosis, is rising among low-income Americans, who are more often diagnosed at late stages and experience lower survival. This research proposal is designed to disentangle the complex reasons that underlie the geographic clustering of late stage liver cancer diagnoses within communities of lower socioeconomic status. Our findings will contribute to the development of effective and tailored intervention strategies to increase the early detection of liver cancer in at-risk adults living in the most disadvantaged areas, and consequently, the important public health mission of achieving equitable cancer outcomes.

PI_NAMEs: ZHOU, KALI  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Acculturation;Address;Adult;Affect;American;Area;Cancer Control;Cancer Control Research;cancer diagnosis;Cancer Etiology;cancer health disparity;career development;Caring;Censuses;Cessation of life;Characteristics;Cirrhosis;Clinic;Clinical;Clinical Data;cohort;Communities;Complex;contextual factors;County;Data;Data Linkages;data registry;Data Reporting;Data Set;density;deprivation;design;Detection;Development;Diagnosis;Disadvantaged;Disease Management;Disparity;disparity reduction;Early Diagnosis;effective intervention;environmental enrichment for laboratory animals;epidemiology study;Equity;ethnic minority;Ethnic Origin;Etiology;evidence base;experience;Failure;Fostering;Foundations;Frequencies;Future;Geography;Goals;Growth;Health;health care service utilization;Image;imaging facilities;Immigrant;improved;improved outcome;Incidence;Individual;innovation;Intervention;intervention delivery;Intervention Trial;Interview;Knowledge;Language;Liver diseases;Location;Los Angeles;Low income;Low Income Population;low socioeconomic status;Maintenance;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of liver;Malignant Neoplasms;Maps;Mediating;Medical Records;Mentors;Mentorship;Methodology;Mission;Modeling;multilevel analysis;National Institute on Minority Health and Health Disparities;Neighborhoods;neoplasm registry;Newly Diagnosed;Outcome;Pathway interactions;patient engagement;Patient Self-Report;Patients;Persons;Population;population based;Predisposing Factor;Primary carcinoma of the liver cells;primary outcome;Process;Prognosis;Prognostic Factor;prospective;Provider;Public Health;Qualitative Methods;Questionnaires;racial minority;Randomized;recruit;Registries;Reporting;Research;Research Personnel;Research Proposals;residence;Resource-limited setting;Resources;Risk;Role;safety net;Science;Screening for Hepatocellular Cancer;secondary outcome;Selection Bias;Services;Severities;social;social determinants;social health determinants;sociodemographics;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Status;socioeconomics;Stage at Diagnosis;stakeholder perspectives;Strategic Planning;Structure;Surveys;System;Techniques;Technology;Testing;theories;therapy design;Training;transportation access;Tumor Biology;Underserved Population;United States;Update;urban area;Urban Population;Work

PROJECT_TITLE: Multilevel Determinants of Socioeconomic Disparities in Geographic Late Stage Hepatocellular Carcinoma Hotspots


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Suicide

PHR: Many patients with borderline personality disorder (BPD) attempt suicide and up to 5-10% die by suicide, but clinicians find it difficult to judge which patients are at the highest risk of dying by suicide, and when. This study seeks to understand not only who is at risk, but also how the level of risk changes over years, days and even minutes.

PI_NAMEs: DOMBROVSKI, ALEXANDRE Y. (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: antagonist;Arousal;Behavioral;Borderline Personality Disorder;callous unemotional trait;Chronic;Clinical;Cognitive;cognitive load;cohort;Computer Models;Decision Making;Development;Dimensions;Disease susceptibility;Disinhibition;Distress;emotion dysregulation;Emotional;Entropy;Equilibrium;experience;Face;Feeling suicidal;Functional disorder;Functional Magnetic Resonance Imaging;Grain;high risk;Hour;Human;ideation;Impairment;improved;Impulsivity;individual response;individual variation;innovation;interpersonal conflict;Intervention;Investigation;Learning;Life;Link;Machine Learning;Measures;Methods;Modeling;National Institute of Mental Health;negative affect;neurobehavioral;Neurocognitive;neuromechanism;Neurosciences;Neurotic Disorders;Pathway interactions;Patient Self-Report;Patients;Personality;Personality Disorders;personalized predictions;Persons;Process;Productivity;programs;prospective;psychobiology;Psychological reinforcement;Psychopathology;Publications;recruit;Research;Research Domain Criteria;Research Personnel;Research Priority;Resources;response;Risk;Risk Factors;Sampling;Social Environment;suicidal;suicidal behavior;suicidal individual;suicidal risk;Suicide;Suicide attempt;suicide model;Symptoms;Thinking;Time;trait;Uncertainty;Withdrawal;Work

PROJECT_TITLE: Psychobiology of Suicidal Behavior in Borderline Personality Disorder

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Social Determinants of Health;Substance Misuse

ORG_CITY: TAMPA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative A lack of diversity among investigators is a strong impediment to resolving national and global challenges related to substance misuse. Certain students face multidimensional historical and social factors that hinder access to adequate mentorship, quality instruction, focused faculty attention, and the financial support necessary to become a future substance misuse and addition scientist. The proposed program, the Substance Misuse and Addiction Research Traineeship (SMART), is a trans-disciplinary drug abuse research education program for undergraduate students dedicated to enhancing diversity in the next generation of substance misuse and addiction scientists.

PI_NAMEs: JOHNSON, KIMBERLY ANN;JOHNSON, MICAH  (contact)

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: Active Learning;Address;Affect;Attention;Award;Awareness;career;Communities;Dedications;Degree program;Dimensions;Disabled Persons;disabled students;Disadvantaged;disadvantaged background;disadvantaged student;Disparity;Disparity population;Diverse Workforce;Drug abuse;drug misuse;Drug usage;Education;education research;Employment;Environment;Epidemic;experience;Face;Faculty;Financial Support;First Generation College Students;Florida;Funding;Future;Gifts;Goals;Graduate Degree;graduate school;health disparity;improved;Individual;innovation;Instruction;International;Leadership;Life;Low Income Population;lower income families;Manuscripts;matriculation;Mentors;Mentorship;minority communities;Minority Groups;minority undergraduate;Mission;National Institute of Drug Abuse;neighborhood disadvantage;next generation;Outcome;Ozone;Positioning Attribute;posters;Prevention;Productivity;Professional Practice;programs;Publications;Qualifying;racial disparity;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Scholarship;Science;Scientist;skills;social factors;Strategic Planning;student training;Students;Substance Addiction;substance misuse;Substance Use Disorder;substance use treatment;Talents;Traineeship;Training;Travel;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Woman;Writing

PROJECT_TITLE: The Substance Misuse and Addiction Research Traineeship (SMART)


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Genetics;Human Genome;Mental Health;Mental Illness;Psychosis;Schizophrenia;Serious Mental Illness;Substance Misuse

PHR: Project Narrative Cannabis involvement is heritable and is more common in those with psychosis-related behaviors and schizophrenia, but the contributions to this co-occurrence remain unclear. This proposal aims to better understand the specific variants, genes, and biological pathways that underlie these behaviors, test for a causal relationship using a genetically-informed design, incorporate transcriptomic and epigenetic data from human and rodent studies to prioritize genes and pathways for functional follow-up, and examine whether polygenic risk for cannabis use disorder and schizophrenia predicts psychosis-related behaviors in population-based and/or high- risk samples. This line of research will advance our understanding of the genetic etiology of these frequently- comorbid behaviors, train the applicant in the use of multi-omic approaches particularly related to cannabis and schizophrenia neurobiology, and ultimately produce translationally-relevant results informed by multiple lines of evidence.

PI_NAMEs: JOHNSON, EMMA COVEY (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Accounting;actionable mutation;Acute;addiction;Address;adverse outcome;Animal Model;Antipsychotic Agents;Behavior;Behavioral;Bioinformatics;Biological;Biology;Cannabis;Cannabis policy;career;career development;causal variant;Child;Childhood;Chronic;Clinical;clinical effect;clinical translation;comorbidity;cost;Data;Data Analyses;data integration;Data Set;design;Development;Disease;Educational Status;Epigenetic Process;Etiology;experimental study;Exposure to;first episode psychosis;follow-up;Foundations;Funding;Future;Gene Expression;General Population;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;genetic variant;genome wide association study;genome-wide;Goals;Heritability;high risk;human data;human model;human tissue;Incidence;Individual;insight;Investigation;Leadership;longitudinal course;Maps;marijuana legalization;marijuana use;marijuana use disorder;marijuana user;Mediating;Mental Depression;Mental disorders;Mentored Research Scientist Development Award;Mentorship;Motivation;Multiomic Data;multiple omics;Neurobiology;novel;Outcome;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pleiotropism;polygenic risk score;Population;population based;Positioning Attribute;Predisposition;Prefrontal Cortex;psychiatric comorbidity;Psychoses;psychosocial;Psychotic Disorders;Public Health;Recording of previous events;Recreation;Relapse;REM Sleep;Reporting;Research;Research Personnel;Risk;Rodent;Rodent Model;Role;Sampling;Schizophrenia;skill acquisition;Source;Subgroup;substance use treatment;Suicide;Testing;Tetrahydrocannabinol;Therapeutic;Time;Tissue Model;Tissues;Training;transcriptomics;United States;United States National Institutes of Health;US State;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Identifying genetic sources of comorbidity between cannabis and schizophrenia using genome-wide and integrative omics data

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


PHR: Metabolic dysfunction and the incidence of chronic disease increase markedly in women following menopause. However, the role of estrogen action in protecting against chronic inflammation and impaired metabolic homeostasis remains inadequately understood. We intend for our work to provide mechanistic insight into the aging-related changes in metabolism and immune health that occur in women following menopause in order to facilitate the development of novel strategies to combat metabolic-related chronic diseases.

PI_NAMEs: HEVENER, ANDREA L (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Adipocytes;Adipose tissue;aging related;Agonist;Anabolism;animal resource;Animals;Aorta;Area;Arterial Fatty Streak;Atherosclerosis;Biological Assay;Bone Marrow;Breast;Cardiometabolic Disease;cardiometabolism;Catalytic Domain;Cell Physiology;cell type;Cells;chromatin immunoprecipitation;Chronic;Chronic Disease;Clinical;combat;Core Facility;Data;design;Development;differential expression;Disease;Disease susceptibility;disorder risk;Dissection;ESR1 gene;Estrogen decline;Estrogen Receptors;Estrogens;feeding;Female;Genes;Goals;Health;High Fat Diet;Homeostasis;Hormone replacement therapy;Human;immune health;Immunomodulators;Impairment;improved;Incidence;Inflammation;Inflammatory;inhibitor;insight;Insulin;Insulin Resistance;insulin sensitivity;interest;Interleukin-1 beta;Iron;iron metabolism;Liver;Macrophage;male;Mediating;men;Menopause;Metabolic;Metabolic dysfunction;Metabolic syndrome;Metabolism;Mitochondria;Mitochondrial DNA;mitochondrial metabolism;Modeling;Molecular;Morphology;mouse model;Mus;Muscle Cells;Myelogenous;Myeloid Cells;new therapeutic target;novel;novel strategies;Nuclear;Obese Mice;Obesity;obesity development;Outcome;overexpression;Pathway interactions;Perimenopause;Phenotype;Polymerase;Positioning Attribute;Postmenopause;prevent;Production;Proteins;Proteomics;Regulation;Regulatory Element;reproductive;Research;response;restoration;RNA;Role;selective expression;sex;Signal Transduction;single-cell RNA sequencing;Spleen;Technology;Testing;Tissues;tool;weapons;Woman;Work

PROJECT_TITLE: The impact of ERalpha on mitochondrial function in macrophages

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND STATE DEPT OF HEALTH

ORG_STATE: RI

PHR: Rhode Island Pregnancy Risk Assessment Monitoring System (PRAMS) RFA-DP-21-001  Component A – Core Surveillance RESEARCH & RELATED Other Project Information  8. Project Narrative Rhode Island (RI) PRAMS will promote data sharing and partner engagement at the statewide level by analyzing and disseminating surveillance findings to key stakeholders to facilitate public health decision making. RI PRAMS is not a research training program.

PI_NAMEs: VINER-BROWN, SAMARA I (contact)


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: CLEVELAND

ORG_NAME: ADVANCED IMAGING RESEARCH, INC.

ORG_STATE: OH

PHR: NIH SBIR PA-18-871 w/o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System High spatial resolution brain magnetic resonance imaging is necessary to help predict neuro- developmental outcome in infants and adults by reliably mapping dynamic anatomical and functional connectivity. Vulnerable infants unstable to survive transport to the current remote MRI scanners can miss their window of therapy or clinical intervention intended to save lives. The overall goal of this SBIR project is to create a compact MRI system with strong connectome gradients and advanced receive RF coil technology, by combining innovations in patient-centric care and salient imaging technology for stat imaging small children and the adult brain in any hospital department.

PI_NAMEs: SRINIVASAN, RAVI  (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: 2 year old;Adult;Affect;Anatomy;animal imaging;Animals;Brain;Brain imaging;brain magnetic resonance imaging;cardiac intensive care unit;Caring;Child;Child health care;Childhood;Clinical;Clinical Trials;Complex;Congenital Disorders;connectome;cost;Custom;design;Detection;Development;Diagnosis;diagnostic tool;Diffusion;effectiveness validation;Feedback;Functional Magnetic Resonance Imaging;Goals;Growth;Head;Heart Diseases;high risk infant;Hospital Departments;Hospitals;Human;Image;Image Enhancement;Imaging technology;Individual;Infant;Injury;innovation;Intervention;Ionizing radiation;Limb structure;Lung Diseases;Magnetic Resonance Imaging;Maps;Measures;Mental disorders;Mental Health;Musculoskeletal Diseases;Neonatal;Neonatal Intensive Care Units;neonate;Nervous System Disorder;Neurodegenerative Disorders;neuroimaging;Newborn Infant;Organ;Outcome;Patient Care;Patients;pediatric patients;Performance;Phase;preterm newborn;prototype;Radiology Specialty;repaired;Research;Research Support;Resolution;RF coil;Risk;Safety;Scanning;Serial Magnetic Resonance Imaging;Small Business Innovation Research Grant;Specific qualifier value;Stroke;success;System;Technology;Testing;tool;transmission process;trend;United States National Institutes of Health;whole body imaging

PROJECT_TITLE: A SAFE AND COMPACT NEONATE TO ADULT NEUROIMAGING MRI SYSTEM


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Little is known how HIV affects the brain in the era of combination antiretroviral therapy, and how drug abuse, including cocaine and opiates, could be detrimental to the HIV infected brain. Our project, using human tissues from the Manhattan HIV Brain Bank, will explore genome organization and function in specific brain cells and neural circuits of the HIV infected brain in the context of opiate or cocaine abuse.

PI_NAMEs: AKBARIAN, SCHAHRAM  (contact);MORGELLO, SUSAN

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Acute;Affect;Antibodies;antiretroviral therapy;Area;Astrocytes;Autopsy;Biological Assay;Brain;brain cell;brain tissue;CD3 Antigens;CD4 Positive T Lymphocytes;CD44 gene;Cell Culture Techniques;Cell Nucleus;Cell surface;cell type;Cells;Central Nervous System Diseases;Cessation of life;Chromatin;Chronic;Cocaine;Cocaine Abuse;cocaine exposure;cohort;Complex;Corpus striatum structure;Cytoplasm;deep sequencing;Diagnosis;Diagnostic;Disease;DNA;Documentation;domain mapping;Dorsal;Drug abuse;drug of abuse;DSM-V;EGF gene;Elements;Epidemic;Epidermal Growth Factor Receptor;epigenome;epigenomics;experimental study;Exposure to;Freezing;Genome;genome-wide;genomic locus;Genomics;Goals;Hi-C;high dimensionality;High Prevalence;high risk;histone modification;HIV;HIV Genome;HIV Infections;HIV Seronegativity;HIV-associated neurocognitive disorder;HIV/AIDS;Human;human tissue;In Situ Hybridization;Individual;innovation;insight;integration site;Interview;ITGAM gene;Ligands;Link;longitudinal analysis;lymph nodes;Lymphocyte;Maps;Microglia;Midbrain structure;Molecular Conformation;Monitor;Morphine;Neostriatum;neural;neural circuit;neuroAIDS;Neuroanatomy;Neurobehavioral Manifestations;Neurobiology;Neurocognitive;neurogenomics;Neurologic;Neurologic Symptoms;Neurological status;Neurons;Neuropathogenesis;novel;Nuclear;Nuclear Pore;Oligodendroglia;Opioid;opioid abuse;opioid exposure;Pathogenesis;Peripheral;Persons;Phase;Plasma;Population;Prefrontal Cortex;prospective;PTPRC gene;Recording of previous events;RNA;Site;Sorting;Spleen;Structure;Substance abuse problem;Substance Use Disorder;Syndrome;T-Lymphocyte;therapy adherence;Toxicology;Transcript;transcriptome;Urine;Viral;Viral Load result;Virus Integration;Virus Latency;Virus Replication

PROJECT_TITLE: CELL - AND CIRCUIT - SPECIFIC EXPLORATION OF HIV NEUROGENOMICS IN CONTEXT OF OPIATE AND COCAINE ABUSE


ORG_CITY: CARSON CITY

ORG_NAME: HEALTH AND HUMAN SERVICES, NEVADA DEPARTMENT OF

ORG_STATE: NV

PHR: Narrative  Component A: Core Surveillance Nevada Pregnancy Risk Assessment Monitoring System (PRAMS): RFA-DP-21-001 Project Narrative The Nevada Pregnancy Risk Assessment Monitoring System (PRAMS) will improve surveillance of maternal and infant health key indicators such as infant morbidity and mortality, access to prenatal care, and maternal behaviors during pregnancy and early infancy. Data obtained from this surveillance will be used to shape maternal and child health programs and policies in Nevada. PRAMS will advance the Nevada Division of Public and Behavioral Health (DPBH), Maternal, Child, and Adolescent Health (MCAH) Section’s mission to improve the health of mothers and infants statewide.

PI_NAMEs: IVES, VICKIE  (contact)

PROJECT_TITLE: RFA-DP-21-001 Nevada Pregnancy Risk Assessment Monitoring System


ORG_CITY: WATERBURY

ORG_NAME: VERMONT STATE AGENCY OF HUMAN SERVICES

ORG_STATE: VT

PHR: The Vermont Pregnancy Risk Assessment Monitoring System is a population- based surveillance system that provides state-specific data for improving the health of mothers and their infants. The information from this program is used to identify problems, to develop policies and programs, and to evaluate the effectiveness of these activities.

PI_NAMEs: BROZICEVIC, PEGGY MARY (contact)

PROJECT_TITLE: RFA-DP-21-001 Component A: Vermont Pregnancy Risk Assessment Monitoring System


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Neurosciences;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Narrative: This proposal is focused on new genetic and molecular pathways that cause and sustain small cell lung cancer and potentially other related tumors. This research is relevant to public health because it will ultimately lead to a better understanding of the causes for a deadly cancer and provide new approaches to cancer therapy.

PI_NAMEs: EISENMAN, ROBERT NEIL (contact);MACPHERSON, DAVID

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Acceleration;Affect;Apoptosis;Automobile Driving;Binding;Binding Sites;Biological;biological systems;cancer therapy;Candidate Disease Gene;candidate identification;Carbon;Cell Line;Cell model;Cell Proliferation;Cells;ChIP-seq;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Common Carcinoma;Complex;Data;Dimerization;Epigenetic Process;Equilibrium;Etiology;Family;Family member;gain of function;Gene Expression;Genes;Genetic;Genetic Transcription;Genome Stability;Genomic DNA;Genomic Instability;Genomics;Germ Lines;Growth;Heterodimerization;Human;in vivo;in vivo Model;Laboratories;Lesion;loss of function;Malignant Epithelial Cell;Malignant neoplasm of thyroid;Malignant Neoplasms;medullary thyroid carcinoma;member;Metabolic Pathway;Metabolism;Modeling;Molecular;Molecular Analysis;mortality;mouse model;Mus;mutant;Mutation;MYC Family Protein;MYCL1 gene;MYCN gene;Neoplasms;neoplastic;neuroendocrine cancer;Neuroendocrine Tumors;Neurosecretory Systems;novel;novel strategies;Oncogenic;overexpression;Pathway interactions;pharmacologic;Phenotype;Pheochromocytoma;Proliferating;Property;Proteins;Public Health;Reporting;Research;Role;Site;small cell lung carcinoma;System;therapeutic target;Thyroid Gland;Time;TP53 gene;transcription factor;transcriptome sequencing;tumor;Tumor stage;Tumor Suppression;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;whole genome;Work

PROJECT_TITLE: Investigating Max as a tumor suppressor gene in small cell lung cancer and other neuroendocrine tumors

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Bioengineering;Mental Health

ORG_CITY: BOTHELL

ORG_NAME: DPLEXBIO INC.

PHR: Project Narrative Real-time PCR is the current gold standard in molecular diagnostics. A next-generation technique, digital PCR, offers important advantages over real-time PCR, but at the expense of being complex, expensive, and low-throughput—not well suited for use in a clinical laboratory or when dealing with large numbers of samples. The proposed emulsion digital PCR (edPCR) system addresses these limitations of current digital PCR and improves its performance by using variable volume droplets created simply by shaking the sample in the presence of PCR reagents and an oil/emulsifier mix to create an emulsion.

PI_NAMEs: ALLEN, PETER B (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 3-Dimensional;Address;Archives;Biological Assay;Clinical;clinical diagnostics;Clinical Research;Complex;Computer Simulation;Computer software;Concentration measurement;cost;COVID-19;Custom;data acquisition;Data Collection;Dedications;Dependence;detection sensitivity;Diagnostic;digital;DNA;Emulsions;Exhibits;fluorescence imaging;fluorescence microscope;genome integrity;Head;Image;improved;innovation;instrument;Laboratories;Light;Measurement;Measures;Methods;Microfluidic Microchips;microscopic imaging;Microscopy;molecular diagnostics;next generation;Noise;Nucleic Acids;Oils;operation;Optics;Outcome;Performance;point of care;Reagent;Reproducibility;Reproducibility of Results;Resolution;Running;Sampling;SARS-CoV-2 infection;Side;simulation;Source;Speed;System;Techniques;Testing;Three-Dimensional Imaging;Time;Uncertainty;Viral Genome;Work

PROJECT_TITLE: Emulsion digital PCR


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Immune activation in the brain due to illness or injury increases risk for memory problems during aging and dementias including Alzheimer’s Disease. These long-term effects of inflammation on the brain raise the question of whether the COVID-19 global pandemic might cause a surge in Alzheimer’s disease cases in the decades to come. In this project, we will identify how a temporary sickness that mimics inflammation caused by mild COVID-19 cause long-term changes in brain function, memory impairments, and faster Alzheimer’s disease progression that emerge long after recovery from illness.

PI_NAMEs: TRONSON, NATALIE CELIA (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Adult;Affect;age acceleration;age related;Age-associated memory impairment;Aging;aging related;Agonist;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;APP-PS1;behavior test;Behavioral;beta amyloid pathology;Brain;chemokine;cognitive function;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 survivors;cytokine;Data;Dementia;dementia risk;Disease Progression;Female;Future;Gene Expression Profiling;Genotype;Goals;Hippocampus;Immune;immune activation;Immune signaling;Impaired cognition;Individual;Inflammation;Inflammatory;Injury;Interferon Type I;Knowledge;Laboratories;Lipopolysaccharides;Long COVID;Long-Term Effects;male;Mediating;Memory;Memory Disorders;Memory impairment;Memory Loss;Microglia;middle age;Molecular Analysis;mouse model;Mus;Nerve Degeneration;Neuroimmune;Neuroimmunomodulation;neuroinflammation;Neuronal Plasticity;novel;pandemic disease;Pathway interactions;Persons;Play;Population;post-COVID-19;Prevention strategy;Preventive treatment;Process;Protein Biochemistry;Protocols documentation;Recovery;Reporting;Research;Resolution;Risk;Risk Factors;Risk Reduction;RNA Viruses;Role;Senile Plaques;sex;Sex Differences;Signal Transduction;Survivors;Symptoms;tau aggregation;Testing;Time;TLR3 gene;TLR4 gene;TLR7 gene;TLR8 gene;Transgenic Mice;Virus;Wild Type Mouse;Woman;Work;young adult

PROJECT_TITLE: COVID-19 related inflammation as a risk factor for age-related cognitive decline and Alzheimer's Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]