ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Nemaline myopathy with intranuclear rods is a rare and severe disorder of skeletal muscle leading to infantile-onset muscle weakness and death in early childhood caused by a subset of pathogenic variants in ACTA1, which encodes the skeletal muscle-specific α-actin (SKA), in particular those affecting Val163. The eponymous intranuclear rods are made up of SKA, and we propose to study whether SKA has nuclear functions in healthy skeletal myocytes that are disrupted by the formation of intranuclear rods. We will test the hypothesis that nuclear SKA is required for complete differentiation of skeletal myocytes, and that incomplete differentiation in cells with ACTA1 p.Val163 variants underlies the severe and early-onset disease.

PI_NAMEs: KWARTLER, CALLIE S (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: ACTA1 gene;Actins;Affect;Alleles;alpha Actin;ATAC-seq;Automobile Driving;beta Actin;Binding;Binding Proteins;Biological Assay;Biopsy;Birth;Cell Differentiation process;Cell division;cell fate specification;Cell Line;cell motility;Cell Nucleus;Cell Shape;Cells;Cessation of life;Child;Childhood;Chromatin;Chromatin Remodeling Factor;Co-Immunoprecipitations;congenital myopathy;CRISPR/Cas technology;Data;Defect;Development;Diagnosis;Differentiated Gene;differentiation in vitro;differentiation protocol;Disease;early childhood;early onset;Epigenetic Process;Fiber;Genes;Genetic Recombination;genomic locus;Heterozygote;Histologic;Histology;human induced pluripotent stem cells;human model;Impairment;improved;In Situ;in vivo;induced pluripotent stem cell;infancy;innovation;Knock-in;Knock-in Mouse;LoxP-flanked allele;Maintenance;Microscopy;Modeling;Molecular;Motor;mouse model;Mus;Muscle;Muscle Cells;Muscle Contraction;Muscle Fibers;Muscle satellite cell;Muscle Weakness;mutant;Myoblasts;Myopathy;Nemaline Myopathies;Neuroectodermal Cell;novel;Nuclear;Onset of illness;overexpression;Pathogenicity;Pathologic;Pathology;Patients;Phenotype;pluripotent stem cell differentiation;prevent;Process;progenitor;promoter;Proteins;Proteomics;Recurrence;Research;Resolution;Respiratory Failure;Rod;Role;Severity of illness;skeletal;skeletal disorder;Skeletal Muscle;Smooth Muscle;Smooth Muscle Myocytes;stem cells;Structure;Tamoxifen;targeted treatment;Testing;Therapeutic;therapeutic development;transcriptome sequencing;transcriptomics;Variant

PROJECT_TITLE: Nuclear skeletal muscle alpha-actin and intranuclear rod myopathy

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: CHARLESTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Mutations in CHAMP1 are a major risk factor for neurodevelopmental disorders, yet little is known about its function and role in brain development. This proposal utilizes forebrain cortical organoids, calcium imaging, cutting-edge single-cell omics, and in vitro electrophysiology to elucidate the role of CHAMP1 in early-stage human brain development. The findings will provide key insights into how CHAMP1 regulates process related to cell differentiation and proliferation and will potentially inform the development of new therapeutic strategies for CHAMP1-associated neurodevelopmental disorders.

PI_NAMEs: BERTO, STEFANO  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Affect;Apical;autism spectrum disorder;Behavior;Brain;Calcium;Cell Differentiation process;Cell Proliferation;cell type;Cells;Characteristics;confocal imaging;Coupled;Data;Development;differential expression;Electrophysiology (science);epigenomics;excitatory neuron;experimental study;Forebrain Development;Frameshift Mutation;Functional disorder;Genes;Genetic Diseases;genetic risk factor;Genetic Transcription;Heterozygote;high resolution imaging;high risk;Human;human induced pluripotent stem cells;Image;imaging approach;Immunohistochemistry;In Vitro;in vitro Model;insight;Intellectual functioning disability;Kinetochores;Knowledge;Learning;Linkage Disequilibrium;loss of function;loss of function mutation;Maintenance;Maps;Memory impairment;Mental Depression;Metaphase;Microcephaly;Microtubules;migration;Missense Mutation;Mitosis;Molecular;Morphology;mouse model;multiple omics;Mus;Muscle hypotonia;Mutation;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neuroglia;neuron development;Neuronal Differentiation;neuronal excitability;Neurons;Nonsense Mutation;novel therapeutic intervention;novel therapeutics;Organoids;patch clamp;Patients;Play;Population;prenatal;Principal Investigator;Process;Production;programs;Proliferating;Property;Prosencephalon;Proteins;Publishing;Radial;Rare Diseases;rare variant;Regulation;Reporting;Research;Risk Factors;risk variant;Role;segregation;Series;Syndrome;Testing;Time;tool;transcriptomics;translational potential;Zinc Fingers

PROJECT_TITLE: Role of CHAMP1, a neurodevelopmental disorder high risk gene, in human brain development and function

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative/Public Health Relevance Statement Recently, we identified a new role for nucleotide biosynthesis in cellular differentiation. We found that inhibiting nucleotide biosynthesis impairs the ability of multipotent progenitors to become adipocytes while promoting vascular smooth muscle cell signatures. Our proposed studies will investigate the specific mechanism by which nucleotides regulate cell fate switching and whether targeting this pathway in vivo using genetic mouse models promotes angiogenesis.

PI_NAMEs: ZAGANJOR, ELMA  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Adipocytes;angiogenesis;Biochemistry;Biological Assay;Branched-Chain Amino Acids;Catabolism;Cell Differentiation process;Cell Reprogramming;Cell Shape;Cells;Cellular biology;Complex;Environment;fatty acid oxidation;Future;gene regulatory network;Genetic;Genetic Transcription;Glucose;Impairment;In Vitro;in vivo;innovation;Interdisciplinary Study;Investigation;Laboratories;Link;lipid biosynthesis;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;mitochondrial metabolism;mouse model;multiple omics;Multipotent Stem Cells;Nucleotide Biosynthesis;nucleotide metabolism;Nucleotides;Outcome;Pathway interactions;Postdoctoral Fellow;preference;programs;Proliferating;public health relevance;Research;Role;Shapes;Smooth Muscle Myocytes;System;Technology;tool;transcriptome;Vascular Smooth Muscle;Vision;Work

PROJECT_TITLE: Reprogramming cell fate through nucleotide metabolism

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE The goal of this proposal is to bring together the best science from industry and academia to create a state of the art and patient friendly dialysis vascular access; and to then quickly get this to the patients who are desperately waiting for better forms of vascular access.

PI_NAMEs: CRAPO, PETER M;ROY-CHAUDHURY, PRABIR  (contact);WANG, YADONG

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TITLE: Vertically Integrated Approach to Design a Biologically and Mechanically Optimized Vascular Conduit for Dialysis Vascular Access

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine;Prevention;Primary Health Care;Skin Cancer;Social Determinants of Health

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Building on our promising efficacy findings using skin cancer genetic testing information to motivate prevention activities, this study examines the effectiveness and potential moderators and mediators of a precision prevention intervention to reduce tanning and sunburning and increase uptake of skin self-examination and physician-patient conversation about skin cancer prevention and early detection in ethnically diverse patients receiving health care at a federally qualified health center. This study uses a mixed methods approach to obtain information about facilitators and barriers to implementation of the precision prevention intervention to inform strategies enabling successful intervention scale-up.

PI_NAMEs: HAY, JENNIFER L;KANETSKY, PETER A (contact)

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: Address;Adoption;Adult;Affect;Area;Basal Cell;Behavior;Cancer Burden;cancer risk;Caring;Categories;Clinical;clinical practice;Communication;Communities;community advisory board;Community Healthcare;Cutaneous Melanoma;demographics;Early Diagnosis;Education;Effectiveness;effectiveness evaluation;effectiveness/implementation study;effectiveness/implementation trial;efficacy trial;Elements;Ensure;Environment;Environmental Risk Factor;Equity;ethnic diversity;Ethnic Origin;Family;Family health status;Federally Qualified Health Center;Feedback;Florida;Frequencies;Future;Genetic;genetic information;Genetic Risk;genetic testing;Genomic medicine;Genotype;health care settings;Health Expenditures;Health Personnel;Health Professional;Healthcare;high risk;Hour;Hybrids;implementation barriers;implementation determinants;implementation evaluation;implementation facilitators;implementation outcomes;improved;Incidence;Individual;individualized prevention;Inequity;Inherited;interest;Intervention;intervention effect;intervention refinement;Intervention Studies;Intervention Trial;Interview;Life Style;Maintenance;Measures;Mediator;medically underserved;Melanocortin 1 Receptor;Methods;Motivation;non-genetic;Outcome Measure;Participant;Patient Self-Report;Patients;personalized intervention;phenotypic biomarker;Physicians;Population Heterogeneity;precision cancer prevention;prevent;Prevention;Prevention strategy;preventive intervention;Primary Care;primary care setting;primary outcome;Process;Public Health Practice;Qualitative Methods;Race;racial diversity;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Receptor Gene;Recording of previous events;recruit;Reporting;Research;Resources;Risk;Risk Factors;safety net;scale up;secondary analysis;secondary outcome;Self-Examination;sex;Site;Skin;Skin Cancer;skin cancer prevention;skin damage;Skin tanning;social health determinants;Spanish/English;Squamous cell carcinoma;Subgroup;success;successful intervention;Sun Exposure;sun protection;Sunburn;Sunscreening Agents;Testing;the sun;theories;translational potential;Treatment Efficacy;uptake;UV Radiation Exposure;Variant

PROJECT_TITLE: A hybrid effectiveness-implementation trial to integrate precision skin cancer risk feedback in federally qualified health centers

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: MH

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: College Station

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: PROJECT NARRATIVE Concern has been raised over parallel increases in social media use and mental health challenges, particularly for racially/ethnically minoritized adolescents, highlighting the need to understand bidirectional associations between social media use and mental health in these youth. This innovative study will use a longitudinal mixed-method design and ecologically valid assessments to provide missing information critical to understanding the bi-directional dynamics between social media use and mental health among racially/ethnically minoritized adolescents. A more comprehensive and accurate understanding of the risks and protective mechanisms will inform the development of targeted, just-in- time interventions designed to reduce the harm and increase the benefit of social media use for vulnerable underrepresented adolescents.

PI_NAMEs: WANG, JUN  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Adolescence;Adolescent;adolescent mental health;Adopted;adverse outcome;Age;Anxiety;Asian Americans;Attention;Black race;boys;Calibration;Caregivers;Characteristics;Communication;Communities;Complex;cyberbullying;Data;Data Analyses;Data Collection;Data Reporting;design;Development;Discrimination;disparity reduction;Ecological momentary assessment;Equation;ethnic minority;Ethnic Origin;experience;Exposure to;falls;follow-up;Gender;girls;Harm Reduction;Health;health disparity;health equity;high risk population;high school;Hispanic;improved;Individual;Inequality;Inequity;informant;innovation;insight;inter-individual variation;Internet;Intervention;Interview;junior high school;Link;Measures;media use;Mental Depression;Mental Health;Methodology;Methods;Minority;minority children;Mission;Modeling;Outcome;Patient Self-Report;Pattern;peer;Personal Satisfaction;Phase;phase 2 designs;primary caregiver;Procedures;Race;racial discrimination;racial minority;racism;recruit;Research;resilience;response;Risk;Role;Sampling;School-Age Population;service utilization;Services;social implication;Social Interaction;social media;Surveys;Symptoms;Telephone;therapy design;Time;time use;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Social Media Use and Mental Health among Racially/Ethnically Minoritized Adolescents

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: OVERALL – PROJECT NARRATIVE Stroke and other neurological conditions are leading causes of disabilities and healthcare expenses in the US. The vision of the COBRE for Restoration of Neural-Based Function is to be a self-sustaining leader in stroke and neurological recovery and rehabilitation research through world class scientific resources, accessible training programs, and new multidisciplinary faculty hires.

PI_NAMEs: KAUTZ, STEVEN A. (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Acceleration;Aging;Appointment;Area;Award;base;Brain;career development;Centers of Research Excellence;Clinical;cognitive function;cognitive rehabilitation;cohort;Complex;Core Facility;Development;disability;Discipline;Environment;experience;Faculty;Faculty Recruitment;faculty support;Fostering;Funding;Grant;Growth;Healthcare;Home;human capital;Infrastructure;innovation;Institution;interdisciplinary collaboration;International;Intervention;Investments;Laboratories;Leadership;Letters;Medical;medical specialties;Medicine;multidisciplinary;multimodality;Nature;neural;neural circuit;neuroimaging;Neurologic;neurological recovery;neurological rehabilitation;Neuronal Plasticity;Neurophysiology - biologic function;neuroregulation;novel;operation;Phase;Physical Function;Pilot Projects;Population;Process;programs;Publications;Recovery;Recovery of Function;rehabilitation research;Research;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Resources;restoration;Role;Services;South Carolina;Strategic Planning;Stroke;stroke recovery;stroke rehabilitation;technological innovation;technology development;Therapeutic;Time;Training Programs;Translating;United States National Institutes of Health;Universities;Vision

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-4 (C3)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PROJECT_TERMS: Accountability;Animal Experimentation;base;Biometry;Budgets;career development;Centers of Research Excellence;Collaborations;Communities;Data;Decision Making;Development;Enrollment;Ensure;Evaluation;experience;Extramural Activities;Faculty Recruitment;Funding;Goals;improved;Individual;Infrastructure;Inpatients;International;Journals;Lead;Leadership;Manuscripts;Medical;Modeling;Monitor;National Institute of General Medical Sciences;neural;operation;Patient Recruitments;Phase;Pilot Projects;Policies;Program Evaluation;Program Research Project Grants;programs;Publishing Peer Reviews;Quality Control;recruit;Registries;Regulation;Rehabilitation therapy;Reporting;Research;research and development;Research Personnel;Research Project Grants;Resources;restoration;Science;Services;sound;South Carolina;Strategic Planning;success;Supervision;Teacher Professional Development;Training;Universities;University resources;Work

PROJECT_TITLE: Adminitrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Physical Rehabilitation;Rehabilitation

PROJECT_TITLE: Quantitative Behavioral Assessment & Rehabilitation Core (QBAR)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Rehabilitation

PI_NAMEs: GEORGE, MARK S (contact)

PROJECT_TERMS: base;Behavior;Biological Markers;biomedical imaging;Brain;career development;Catalogs;Centers of Research Excellence;Cephalic;Clinical;Complex;Computer Models;cortex mapping;Data;Data Analyses;Diagnostic;Discipline;Educational workshop;Electric Stimulation;Electroencephalography;Environment;Evoked Potentials;experience;Focused Ultrasound;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;functional near infrared spectroscopy;Funding;Goals;Grant;Image;image guided;innovation;Intervention;investigator training;Knowledge;Laboratories;Leadership;Magnetic Resonance Imaging;Measurement;Measures;medical specialties;Mentors;Methodology;Methods;Modality;multidisciplinary;multimodality;Muscle;neural;neural circuit;neuroimaging;neurophysiology;Neurophysiology - biologic function;neuroregulation;novel;Outcome Measure;Periodicals;Phase;Physiological;Population;Rehabilitation Centers;Rehabilitation therapy;Reproducibility;Research;Research Infrastructure;Research Personnel;Resources;restoration;Scientist;Services;skills;stroke recovery;success;Techniques;theories;tool;Training;Translating;United States National Institutes of Health;Work

PROJECT_TITLE: Neural Function Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed studies will utilize an innovative, in vivo fermentation based, RNA molecular bioengineering platform technology to produce a collection of novel biologic RNA molecules to dissect liver cancer cell metabolism and explore new therapies. Results are anticipated to open up new ways to create unparalleled biologic RNA molecules for basic research and drug development.

PI_NAMEs: YU, AIMING  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Abbreviations;Amino Acid Transporter;Amino Acids;Animal Model;antagonist;aptamer;Basic Science;Biological;Biomedical Engineering;Blood Chemical Analysis;Cancer Etiology;cancer therapy;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cellular Metabolic Process;Cessation of life;chemotherapy;clinically relevant;Collection;Combined Modality Therapy;cytokine;design;Development;drug action;drug development;Drug Targeting;Effectiveness;Elements;Engineering;Enzymes;Escherichia coli;Fermentation;Fluorouracil;Focus Groups;Foundations;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genome;Genus Hippocampus;Glucose;Glucose Transporter;Glutaminase;Glycolysis;Goals;Hep3B;hepatocellular carcinoma cell line;high risk;Homeostasis;Human;Hybrids;immunogenicity;Immunotherapy;improved;In Vitro;in vivo;innovation;interest;invention;Investigational Therapies;Isotopes;Liposomes;Liver;liver cancer patient;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;men;Metabolic;Metabolism;metabolome;MicroRNAs;Mitochondria;Modification;Molecular;mouse model;nanocomplexes;nanomedicine;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Nutrient;nutrient metabolism;Oncogenic;Oncolytic;overexpression;Pharmaceutical Preparations;polypeptide;Post-Transcriptional Regulation;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Process;Prodrugs;Production;Proliferating;Property;Protein Biosynthesis;Protein Isoforms;Proteins;Recombinant Proteins;Replacement Therapy;Research;research and development;restoration;RNA;Role;Safety;SLC2A1 gene;Small Interfering RNA;small molecule;Solid;success;Survival Rate;targeted treatment;Techniques;Technology;technology platform;Testing;Therapeutic;Therapeutic Studies;therapeutically effective;Tissues;tool;Transfer RNA;Translational Research;tumor;tumor growth;tumor metabolism;tumor progression;United States;Untranslated RNA;Woman;Xenograft procedure

PROJECT_TITLE: Novel biologic RNA molecules to modulate HCC metabolism

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Using immune cells to target and kill tumor cells is a promising therapeutic approach but currently lacks efficacy for many cancers due to the dysfunction of the immune cells in the tumor. This proposal seeks to identify the optimal modifications to genetically engineer into immune cells to help them resist dysfunction. By engineering new ways to control the transcriptional state of the immune cell, our approaches will improve the anti-tumor efficacy of T cells for multiple cancer types.

PI_NAMEs: FOIGHT, GLENNA WINK (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Antigens;Area;BACH2 gene;Bar Codes;Binding;Biological;Biological Assay;Biology;bZIP Domain;cancer immunotherapy;cancer type;Cell Therapy;Cells;cellular resilience;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Collaborations;Complex;Data;design;design and construction;Dimerization;DNA;Dominant-Negative Mutation;effector T cell;engineered T cells;Engineering;Environment;exhaust;exhaustion;Exposure to;Expression Library;Family;Functional disorder;Funding Mechanisms;Genes;Genetic;Genetic Engineering;Genetic Transcription;Goals;Grant;Human;Immune;Immune System Diseases;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Infiltration;inhibitor;insight;Interferon Type II;JUN gene;knock-down;Knock-out;laboratory experience;Length;Leucine Zippers;Libraries;Literature;Malignant Neoplasms;Maps;member;Memory;Metabolic;Modality;Modeling;Modification;Molecular;Mus;neoplastic cell;novel;novel therapeutics;Nutrient;Other Genetics;Outcome;overexpression;Pathway interactions;Phenotype;pleiotropism;Pre-Clinical Model;prevent;Production;Proliferating;Protein Engineering;Proteins;Publishing;Regulation;Reporting;Research;Resistance;response;Safety;screening;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;Source;Specific qualifier value;Specificity;stem;stoichiometry;stressor;T cell regulation;T cell therapy;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;transcription factor;Transcriptional Regulation;tumor;Tumor Antigens;tumor microenvironment;Uncertainty;Variant;vector;Viral Vector;XBP1 gene

PROJECT_TITLE: Engineering bZIP family transcription factors for therapeutic T-cell persistence and effector function

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Natural Products

ORG_CITY: RICHARDSON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Public Health Relevance Statement The chemical synthesis of bioactive molecules is of pivotal importance to the development of new drugs given the central role natural products have played for decades and continue to play in drug discovery. This proposal outlines the design of new approaches to forge pivotal bonds and access densely functionalized polycyclic frameworks describing their implementations in the efﬁcient preparations of structurally complex, bioactive molecules that already demonstrate promising biological activity. In doing so, these studies lay the foundation for the development of new medicines and accelerate the study and treatment of human diseases.

PI_NAMEs: ROMITI, FILIPPO  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acceleration;Alkaloids;analog;Biological;cancer therapy;chemical synthesis;Chemicals;Collection;Communicable Diseases;Complex;design;Development;drug discovery;Evaluation;forging;Foundations;human disease;innovation;invention;Lead;Logic;Medicine;Methods;Natural Products;Nervous System Disorder;novel strategies;novel therapeutics;Outcome;Play;Preparation;public health relevance;Research;Role;Terpenes;therapeutic development

PROJECT_TITLE: New Methods and Strategies for the Scalable Synthesis of Complex Bioactive Molecules

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Data Science;Neurosciences;Pain Research;Pediatric

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE There is a considerable societal need to better understand neurobiological mechanisms, psychosocial processes, treatments, preventions, and policy in child and maternal pain. This training program aims to develop the next generation of interdisciplinary scientific leaders in child and maternal pain.

PI_NAMEs: AGHAEEPOUR, NIMA ;RABBITTS, JENNIFER ;SIMONS, LAURA E (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: Adolescent;Anesthesiology;Area;Behavioral;behavioral health;Behavioral Sciences;Bioinformatics;biomedical data science;biopsychosocial;career;career development;Child;Childhood;clinical pain;Clinical Research;Clinical Services;cohort;Data Science;Ensure;Epidemiology;Evaluation;experience;faculty mentor;faculty research;Fostering;Funding;Goals;Health;health equity;Health Services Research;Helping to End Addiction Long-term;Institution;Interdisciplinary Study;Intervention;life span;Lived experience;Maternal and Child Health;Maternal Health;medical schools;Medicine;Mentors;Mentorship;Monitor;neurobiological mechanism;Neurosciences;next generation;Output;Pain;pain chronification;pain model;Pain Research;Participant;Patients;pediatric department;Pediatrics;Perioperative;Policies;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Prevention;Process;Productivity;programs;Psychiatry;psychosocial;R24;Records;Research;Research Institute;Research Methodology;Research Training;Schools;Science;Scientist;Secure;skill acquisition;skills;social stigma;Statistical Methods;success;Time;Training;Training Programs;United States National Institutes of Health;Universities;web site;webinar;whole health

PROJECT_TITLE: Interdisciplinary research training in maternal and childhood pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-F (90)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Lung;Lung Cancer;Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: NARRATIVE Each year, smoking kills 8 million people worldwide. Developing scalable, population-level behavioral treatments for smoking cessation is a priority of the National Cancer Institute (NCI) and aligned with the White House’s Cancer Moonshot goal to reduce smoking. This project addresses those priorities by testing the efficacy of a promising mobile health (mHealth) app designed exclusively for people who are not yet ready to quit smoking—the majority of people who smoke. To date, there are currently no effective population-based interventions for this critical group. If this novel intervention is found effective, it could be broadly disseminated, help reduce smoking prevalence, and inform the optimal design of future interventions targeting people who are not yet ready to quit smoking.

PI_NAMEs: HEFFNER, JAIMEE ;MCCLURE, JENNIFER B (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: 2 arm randomized control trial;Abstinence;Address;Adult;Advertising;American;arm;behavior change;Behavior Therapy;Behavioral;Biochemical;Cause of Death;Cessation of life;Cigarette;Cognitive;comparative efficacy;comparison control;cost;Counseling;Country;Data;design;Development;digital treatment;Educational process of instructing;efficacy evaluation;efficacy testing;Enrollment;Evaluation;evidence base;Evidence based intervention;Evidence based treatment;Exercise;experimental arm;experimental study;FDA approved;Feedback;follow-up;Future;Goals;health goals;Healthcare Systems;Hour;innovation;insight;Intervention;Malignant Neoplasms;Measures;mHealth;mhealth interventions;Mobile Health Application;Motivation;motivational intervention;National Cancer Institute;nicotine replacement;novel;Outcome;Participant;Patient Self-Report;Persons;Pharmaceutical Preparations;pilot trial;Population;Population Intervention;preference;Prevalence;primary endpoint;primary outcome;Process;programs;Public Health;public health intervention;public health research;quitline;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research Design;Resources;Rewards;Sampling;satisfaction;Self Direction;Self Efficacy;Series;skills;Smoke;Smoking;smoking abstinence;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;smoking intervention;smoking prevalence;Smoking treatment;social media;Societies;sound;Testing;theories;therapy design;Tobacco;tobacco abstinence;Tobacco use;tool;uptake;user centered design;Vertebral column;Work

PROJECT_TITLE: Evaluation of a Novel mHealth Intervention for People Who Are Ambivalent About Quitting Smoking: A Randomized Controlled Trial

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: Boulder

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Dynamic contrast optical coherence microscopy (DyC-OCM) is distinguished from traditional scattering-based OCT by its emphasis on dynamic fluctuations: the motions of viable cells are accented against the motionless regions in the OCT images, enhancing the image contrast and revealing both cellular morphological and physiological information. In this program, we aim to develop the first 3D DyC-OCM technology that simultaneously breaks through the voxel rate and resolution barriers. We will accomplish the goal by developing a novel swept source architecture and a scalable parallel imaging platform.

PI_NAMEs: HUANG, SHU-WEI  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: 3-Dimensional;Accent;Adopted;Architecture;biomedical imaging;Bite;Cardiology;Cell Survival;Cells;cellular imaging;Cellular Morphology;Cellular Structures;clinical application;contrast imaging;Contrast Media;Coupled;Coupling;Dentistry;Dermatology;Detection;Development;disease diagnosis;Electronics;Elements;Embryonic Heart;Endoscopy;Engineering;experimental study;Eye diseases;Fetal Heart;fluorescence imaging;fluorescence microscope;Goals;Growth;Heart;Human;Human Development;human model;Image;Image Enhancement;imaging modality;imaging platform;imaging system;Imaging technology;improved;In Vitro;in vivo imaging;innovation;integrated circuit;Intervention;Intestines;Label;Length;lithium niobate;Location;Longitudinal Studies;meter;Microscopic;microscopic imaging;Microscopy;millisecond;Morphology;Motion;Nature;Necrosis;novel;Optical Coherence Tomography;Optics;Organelles;Organoids;Penetration;photonics;Physiological;preconditioning;preservation;Procedures;programs;Resolution;Sampling;signal processing;Signal Transduction;silicon nitride;Source;Speed;System;Technology;temporal measurement;Time;Tissues;transmission process;Urology;Validation;waveguide

PROJECT_TITLE: 3D dynamic contrast optical coherence microscopy for organoid studies

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Foodborne Illness;Prevention;Rural Health

ORG_CITY: LAS CRUCES

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: PROJECT NARRATIVE. Consumption of arsenic-contaminated water is associated with an increased risk of lung, hepatobiliary, bladder, kidney, ureter, prostate, breast, and uterine cervix cancers. This project aims to achieve three main objectives: 1) Assess arsenic contamination in rural New Mexico water wells; 2) Identify DNA damage (8-hydroxy-2'- deoxyguanosine) and oxidative stress (F2-isoprostane, 4-hydroxyneonal) biomarkers through urine samples; and 3) Determine arsenic levels in urine specimens of residents from the rural underprivileged New Mexico- Mexico border population, who rely on water for domestic use. The study will investigate the link between arsenic- contaminated well water and the development of associated cancers within this population.

PI_NAMEs: RAHMAN, HUMAIRAT H (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: 8-hydroxy-2'-deoxyguanosine;Acceleration;Address;adduct;Adult;Age;Applications Grants;Area;Arsenic;Biological Markers;Biology;biomarker identification;Biomedical Research;Bladder;Breast;Cancer Burden;cancer diagnosis;Cancer Etiology;cancer risk;carcinogenicity;Carcinogens;career;Caucasians;cell injury;Cessation of life;Chronic;Chronic Disease;Community Health Aides;Consumption;contaminated water;Country;County;Coupled;Dangerousness;Data;Development;Diagnosis;DNA Damage;DNA Markers;Dose;drinking water;Early Diagnosis;Exhibits;experience;Exposure to;F2-Isoprostanes;Face;Future;global health;Goals;graduate student;Hair;hands on research;Health;Hepatobiliary;Hispanic;Household;Human;Human body;Incidence;Individual;Isoprostanes;Kidney;Laboratories;Link;Lipids;low socioeconomic status;Lung;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medicine;metal poisoning;Metals;Mexico;Monitor;Mutation;New Mexico;oxidative DNA damage;Oxidative Stress;oxidized lipid;Participant;Pathway interactions;Patient Self-Report;Persons;Plasma;Play;Poison;Population;prevent;Privatization;Production;programs;Prostate;Public Health;Reactive Oxygen Species;Recording of previous events;Reporting;Research;Research Personnel;research study;Risk;Role;Rural;rural area;rural dwellers;Rural Population;Safety;Sampling;Science;Source;Specimen;Students;Techniques;test strip;Toxic effect;Training;Underrepresented Populations;United States;United States Environmental Protection Agency;Ureter;urinary;Urine;Water;water solution;water testing;waterborne;well water

PROJECT_TITLE: Arsenic Exposure and its Association with Cancers among Residents with Wells in New Mexico's Border Counties

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (SB)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Acute myeloid leukemia patients account for nearly 3500 stem cell transplant procedures annually in the US of which > 2/3 are for individuals aged < 65 and occur in first complete remission (CR1). Relapse after transplant and treatment related mortality remain major obstacles for assuring the long-term effectiveness of these efforts and have high associated mortality. Our proposed investigations using novel induction regimens to more expeditiously gain CR1 in AML patients with rapid progression to allogeneic transplantation, will enhance overall transplant outcomes and provide opportunity to determine optimal measurable residual disease assessments and to directly compare the patient experiences, both in need for hospital care and direct reported outcomes when receiving standard care vs intensive, sequential induction and transplantation.

PI_NAMEs: MAZIARZ, RICHARD THOMAS (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Adult;age group;aged;Allogenic;Biological Assay;Biology;Cells;chemotherapy;CLIA certified;Clinical;Collaborations;Common Terminology Criteria for Adverse Events;comorbidity;conditioning;Consolidation Therapy;cost;Cytarabine;Cytogenetics;Data;Detection;Development;Diagnosis;Disease;Disease remission;disorder control;disorder risk;DNA;DNA sequencing;Donor person;Dose;Effectiveness;Eligibility Determination;Enrollment;EuroQOL;Evaluation;experience;Failure;Flow Cytometry;Fluorescent in Situ Hybridization;Future;Genomics;Health;health care service utilization;Health Resources;Hematology;Hematopoietic Stem Cell Transplantation;high risk;Homologous Transplantation;hospital care;human old age (65+);Immunophenotyping;improved;In complete remission;Individual;Infrastructure;Institution;Investigation;leukemia;Measurable;Measures;member;Methods;Molecular;Morbidity - disease rate;Morphology;mortality;Multicenter Trials;Mutation;Myeloproliferative disease;Newly Diagnosed;next generation sequencing;novel;older adult;Oregon;Outcome;Patient Outcomes Assessments;patient subsets;Patient-Focused Outcomes;Patients;pharmacologic;post intervention;post-transplant;Procedures;prognostic;Protein Analysis;Publishing;Randomized;Regimen;Relapse;relapse risk;Remission Induction;Remission Induction Therapy;Reporting;Research;Research Personnel;Residual Neoplasm;Residual state;Resources;response;Risk;Sampling;Science;Slide;socioeconomics;standard care;Stem cell transplant;Supportive care;Surface;survival outcome;targeted treatment;Therapeutic procedure;Time;tool;Toxic effect;Transplant Recipients;Transplantation;Transplantation Conditioning;Treatment Failure;trial comparing;Umbilical Cord Blood;Underrepresented Minority;Universities;Update

PROJECT_TITLE: BMT Core - Oregon Health and Science University (OHSU) Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (M1)]


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Immunotherapy;Precision Medicine;Sarcoidosis

PHR: Project Narrative Cardiac sarcoidosis is a serious inflammatory disease in the heart that can cause heart failure and arrhythmias. There is limited knowledge about one type of immune cells in the heart that may be causing the disease, called T cells. This project aims to use high-throughput immune profiling technology to study the types of T-cells in the heart during cardiac sarcoidosis, and test whether blocking a receptor called CXCR3 can help direct T-cells away from the heart and reduce cardiac inflammation.

PI_NAMEs: ZHU, HAN  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: adaptive immunity;Adjuvant Therapy;Affect;antigen-specific T cells;Antigens;Arrhythmia;Attenuated;Automobile Driving;biobank;biomarker discovery;black patient;Blood;cancer immunotherapy;cancer therapy;Cardiac;Cardiac Sarcoidosis;cardioprotection;Cardiotoxicity;Cause of Death;CD4 Positive T Lymphocytes;cell motility;Cell Physiology;Cell Separation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chemokine receptor;Clinical;clinical care;Clonal Expansion;Clonality;Clone Cells;Collaborations;CXCL9 gene;Cytometry;Data Set;Development;Disease;experience;Goals;Granuloma;Heart;Heart failure;Histology;Human;Immune;Immune checkpoint inhibitor;Immunoglobulin G;Immunology;Immunophenotyping;In Vitro;Inflammation;Inflammatory;innovation;insight;International;ITGAX gene;Knowledge;Ligands;Lung;lymphoid organ;Lymphoid Tissue;Macrophage;Mediating;Methods;migration;mouse model;multidisciplinary;Multiomic Data;multiple omics;Mus;Myocarditis;Natural Immunity;new therapeutic target;non-caseating granulomas;Organ;Pathogenicity;Pathologic;Pathway interactions;Patients;Peripheral;Phenotype;precision medicine;Precision therapeutics;preclinical study;Prevention;programs;Pulmonary Sarcoidosis;receptor;recruit;Research;Research Design;response;Sampling;Sarcoidosis;single-cell RNA sequencing;Specificity;Specimen;STAT4 gene;success;sudden cardiac death;System;T cell receptor repertoire sequencing;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Tissues;tool;transcriptomics;United States;Ventricular Arrhythmia;Work

PROJECT_TITLE: Investigating CXCR3 Blockade as Precision Therapy for Cardiac Sarcoidosis using Single-Cell Multi-omics and TCR Phenotyping

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Caregiving Research;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LONG BEACH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CALIFORNIA STATE UNIVERSITY LONG BEACH

PHR: Active caregiver involvement is a key feature of state-of-the-science early evidence-based interventions (EBIs) for autism spectrum disorder (ASD) and is federally mandated in publicly-funded early intervention services. Latino children are increasingly being diagnosed with ASD at younger ages, yet experience disparities in service access and quality which may extend to disparities in caregiver engagement in services. The present study seeks to characterize patterns and determinants of Latino caregiver engagement in ASD early intervention services as a means of informing culturally- and linguistically-responsive engagement tools.

PI_NAMEs: CAPLAN, BARBARA J (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: 3 year old;Acculturation;Address;Age;Applications Grants;Attention;Attitude;autism spectrum disorder;autistic children;Behavioral;California;career;Caregivers;Caring;Child;Child Mental Health;child services;Clinical;clinical encounter;Clinical Research;Code;Communities;community engaged approach;community partners;Complex;cost;cultural competence;Data;Data Analyses;Data Collection;design;Development;Development Plans;Diagnosis;Dimensions;Disparity;Early identification;Early Intervention;early screening;Educational process of instructing;Ensure;ethnic minority;Ethnic Origin;evidence base;Evidence based intervention;Expectancy;experience;Exploration, Preparation, Implementation, and Sustainment;Family;Feedback;First Independent Research Support and Transition Awards;Funding;Future;Grant;Health;health disparity;health equity;Health Services Research;Hispanic-serving Institution;Immigration;implementation determinants;implementation framework;implementation research;implementation science;improved;Individuals with Disabilities Education Act;Intervention;Interview;Knowledge;Language;Latino;Leadership;Legal;Life Cycle Stages;Linguistics;Link;lower income families;Manuscripts;Mediating;Mental Health;Mentorship;Methods;Modeling;Outcome;Patient Recruitments;Pattern;Policies;Population;Productivity;Provider;Qualitative Methods;Quality Indicator;Quality of Care;racial minority;Recommendation;recruit;Research;Research Personnel;Risk;Science;service intervention;Services;social stigma;Societies;Socioeconomic Status;Spanish;Students;System;Testing;Text;Time;tool;Treatment outcome;Underrepresented Students;Universities;Work;Writing

PROJECT_TITLE: Characterizing Latino Caregiver Engagement in Early Intervention Services for Autism


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Mental Health;Neurosciences;Pediatric;Sleep Research;Stimulant Use and Misuse

ORG_CITY: SAN BERNARDINO

ORG_NAME: CALIFORNIA STATE UNIV SAN BERNARDINO

PHR: PROJECT NARRATIVE Children with attention-deficit/hyperactivity disorder (ADHD) exhibit sleep disturbances. Since the most common treatment for pediatric ADHD is stimulant medication, methylphenidate (MPH), there is interest in whether MPH results in exacerbated sleep disturbances and development of sleeping disorders later in adulthood. This grant will advance the field by better understanding the complex relationship that early psychostimulant exposure and ADHD can have on sleep and neurophysiology.

PI_NAMEs: AMODEO, LESLIE RENEE (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Adolescent;Adolescent Development;Adult;Animal Model;Animals;Architecture;Attention;Attention deficit hyperactivity disorder;Basic Science;Behavior;behavior measurement;Brain;Child;Childhood;circadian;Circadian Dysregulation;Circadian Rhythms;Clinical Research;Clinical Trials;common treatment;Complement;Complex;Darkness;Development;Disease;Disinhibition;Drowsiness;Electroencephalography;Event-Related Potentials;Exhibits;experience;Funding;girls;Goals;Grant;High Prevalence;Hour;Human;Hyperactivity;improved;inattention;Inbred SHR Rats;Inbred WKY Rats;Inbreeding;Individual;interest;Laboratory Research;life span;Light;Link;Long-Term Effects;Modeling;Nervous System Disorder;neurophysiology;Pathology;Patients;Pattern;peer;Periodicity;Pharmaceutical Preparations;Pharmacologic Substance;Play;poor sleep;Population;pre-clinical research;preadolescence;preclinical study;predictive marker;psychostimulant;Rat Strains;Rattus;REM Sleep;Research;response;Ritalin;Rodent;Rodent Control;Rodent Model;Role;sex;Sleep;Sleep Architecture;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep onset;sleep pattern;sleep quality;sleep quantity;Sleeplessness;Stimulant;stimulant exposure;stimulant use;Technology;Therapeutic;Time;translational model;young adult

PROJECT_TITLE: Impact of preadolescent psychostimulants on neurophysiology and sleep/wake disturbances

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (SF)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Estrogen;Menopause;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative:  The transition to menopause is inevitable for aging women and is a stage in her life where she is vulnerable to developing a multitude of psychiatric conditions, including psychosis. The experiments detailed in this application aim to provide a mechanistic understanding into how aberrant regulation of dopamine neuron activity can lead to psychosis-like behavioral deficits in a rodent model used to study perimenopause. We will also investigate the utility of a novel GABAAR positive allosteric modulator that we believe may be used to treat symptoms of psychosis during perimenopause.

PI_NAMEs: LODGE, DANIEL ;PEREZ, STEPHANIE MARIE (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: 4-vinylcyclohexene diepoxide;Adult;Affect;Age;age effect;Age Months;Age Years;Aging;Amphetamines;Antipsychotic Agents;Anxiety;Behavior;Behavioral;Bipolar Disorder;Brain;Clinical;common symptom;Data;debilitating symptom;depression model;design;Development;Dopamine;dopamine system;dopaminergic neuron;Electrophysiology (science);experimental study;extracellular;Female;gamma-Aminobutyric Acid;Genetic;hippocampal pyramidal neuron;Hippocampus;Hormonal;Human;Hyperactivity;Hyperprolactinemia;in vivo;Incidence;insight;Life;Locomotion;Manic;Measures;Menopause;Mental Depression;Mental disorders;Mental Health Associations;mesolimbic system;Methods;Modeling;Motor Activity;neural circuit;novel;novel therapeutic intervention;Ovarian Follicle;Ovariectomy;Pathologic;Perimenopause;Physiological;positive allosteric modulator;postnatal;Pre-Clinical Model;prepulse inhibition;Process;Psychiatric therapeutic procedure;Psychoses;Psychotic Disorders;psychotic symptoms;Quality of life;Rattus;receptor;Regulation;Risk;Rodent;Rodent Model;Schizophrenia;side effect;Sprague-Dawley Rats;Stimulant;symptom treatment;Symptoms;Therapeutic;Therapeutic Effect;Therapeutic Intervention;Time;translational model;Ventral Tegmental Area;Weight Gain;Woman

PROJECT_TITLE: Aberrant dopamine system function in a rodent model of perimenopause: relevance to psychosis

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Interpersonal trauma (IT) is a social determinant of health causing enduring adverse impacts on victims’ biopsychosocial and emotional health. The purpose of this exploratory sequential mixed methods study is to generate a rich understanding of the impact of exposure to IT on engagement in care (EIC) among Latino immigrant men living with HIV (LIMWH) and the protective resources such as emotional support (ES) that can be promoted to address psychosocial and HIV-related disparities in this population. This study will advance the sciences of trauma-informed-care, HIV management, psychosocial health promotion, and health engagement for Latino immigrant men and inform future clinical and community-based interventions and research.

PI_NAMEs: SMITH, OWEN WOODFIELD (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Address;Adherence;Area;Baltimore;Behavioral;behavioral health;biopsychosocial;Buffers;care providers;Caring;Clinical;community intervention;Continuity of Patient Care;Data Analyses;Development;Diagnosis;Discrimination;Disparity;Emotional;emotional distress;Epidemic;Evaluation;experience;Exposure to;Future;Goals;Health;Health Promotion;Healthcare;high risk;HIV;HIV diagnosis;HIV disparities;Immigrant;Immigration;improved;Individual;International;Interpersonal Relations;interpersonal trauma;Intervention;Interview;Investigation;Latino;Latino Population;life span;Literature;Logistic Regressions;member;men;men who have sex with men;Mental disorders;Mental Health;Mental Health Services;Methods;migration;Modeling;National Institute of Nursing Research;Newly Diagnosed;Outcome;patient oriented;Patients;peer;Persons;Population;Process;Provider;psychologic;Psychological adjustment;Psychological Impact;psychosocial;Psychosocial Factor;psychosocial resources;psychosocial wellbeing;Qualitative Methods;Quality of life;racial minority;racial minority status;Recording of previous events;Research;Research Support;Resources;Risk;Safety;Science;sexual minority;sexual minority status;social;social disparities;social health determinants;Social Identification;Social isolation;social relationships;Social status;social stigma;Social support;Structure;Subgroup;Surveys;Testing;Trauma;trauma exposure;traumatic event;Trust;Violence;Viral;Washington

PROJECT_TITLE: Engagement in Care and Emotional Support in the Context of Interpersonal Trauma among Latino Immigrant Men with HIV: A Mixed-Methods Investigation

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(85)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ARLINGTON

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: PROJECT NARRATIVE  Driven by structural racism, non-Hispanic Black women are two times as likely as non-Hispanic White women to suffer from severe maternal morbidity, which increases risk for maternal mortality. Using participatory system dynamics modeling methodologies, this project will generate a holistic understanding of the dynamically complex systems that perpetuate severe maternal morbidity disparities among non-Hispanic Black women. This understanding will then be transformed into a system dynamics simulation model that will be developed, tested, analyzed, and disseminated to provide an evidence-based decision-making tool to inform intervention strategies.

PI_NAMEs: BROWN, KYRAH K (contact);LEMKE, MICHAEL KENNETH

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Area;black women;Calibration;Childbirth;Clinical;Communities;Complex;Coupled;dashboard;Data;Data Set;Decision Making;Development;Discipline;disparities in morbidity;Disparity;disparity reduction;Distal;dynamic system;economic determinant;Economics;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Elements;Equity;evidence base;Feedback;Fostering;Health;health determinants;Health Disparities Research;health disparity;Healthcare;Individual;insight;Intervention;Knowledge;Learning;Life Cycle Stages;Literature;Maternal Health;Maternal Mortality;maternal risk;Methodology;Methods;metropolitan;model building;Modeling;models and simulation;Municipalities;Not Hispanic or Latino;novel;Outcome;Participant;Pathway interactions;population health;Prevention;Prevention strategy;Process;Public Health;Race;racial discrimination;Research;Research Methodology;Research Personnel;Risk Factors;Science;severe maternal morbidity;Shapes;simulation;social;social determinants;Social Policies;Societies;Structural Racism;System;Testing;Texas;Time;tool;Translating;United States;Validation;web site;White Women

PROJECT_TITLE: Complex Systems Approaches to Advance Maternal Health Disparities Research and Prevention: Developing a System Dynamics Simulation Model of Severe Maternal Morbidity among Black Women

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Aging;Clinical Research;Osteoporosis;Physical Injury - Accidents and Adverse Effects

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE: A previous fracture is one of the best predictors of future fracture risk, but the causes of this relationship are unclear. Systemic bone loss following a fracture is an understudied process that may contribute to a decrease in bone strength and increase fracture risk at all skeletal sites. In the proposed studies we will investigate systemic bone loss following an upper arm fracture in human subjects, determine how this injury response is different in older people vs. younger people, and explore potential mechanisms driving this process.

PI_NAMEs: CHRISTIANSEN, BLAINE A.;KAZAKIA, GALATEIA J (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Accelerometer;Address;Affect;Age;age difference;aging population;American;Automobile Driving;Bilateral;Biological Markers;Biomechanics;bone;Bone callus;Bone Density;bone loss;bone mass;Bone Mineral Contents;bone quality;Bone remodeling;bone strength;Clinical;Clinical Data;Contralateral;cortical bone;cost;Data;density;Dual-Energy X-Ray Absorptiometry;Epidemiology;Etiology;Failure;fall risk;Femoral Fractures;Femur;Finite Element Analysis;Forearm;Fracture;fracture risk;Future;Goals;Health;high resolution imaging;Hip region structure;Human;human subject;Humeral Fractures;Image;improved;Ipsilateral;Knowledge;Limb structure;Measures;mechanical properties;Minerals;Mus;novel;Older Population;Osteitis;Osteoporosis;osteoporosis with pathological fracture;partial recovery;Patients;Peripheral;Persons;Physical activity;Porosity;preclinical study;Process;Questionnaires;Radial;Recording of previous events;Recovery;recruit;Research;Resolution;response;response to injury;Serum;Site;skeletal;skeletal preservation;Skeleton;Structure;substantia spongiosa;systemic inflammatory response;Testing;Therapeutic;therapeutic target;therapeutically effective;tibia;Time;timeline;Tissues;Upper arm;Upper Extremity Fracture;Vertebral column;Width;X-Ray Computed Tomography

PROJECT_TITLE: Systemic Bone Loss Following Fracture in Humans

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Glioblastoma (GBM) is a deadly malignant brain tumor with poor survival outcomes attributed to low efficacy of standard treatment strategies. Cell therapies are a promising new platform for treating GBM, however, therapeutic cells injected into the GBM post-resection cavity are rapidly cleared from the brain, resulting in limited therapeutic durability. We propose the development of a novel 3D printing technique known as bioprinting, in which therapeutic cells are embedded in a 3D printed hydrogel for use as a protective cell delivery system for treating GBM.

PI_NAMEs: KASS, LAUREN  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: 3-Dimensional;3D Print;Acrylates;Adult;Affect;Architecture;Biochemical;Biocompatible Materials;Biological Assay;bioluminescence imaging;biomaterial compatibility;bioprinting;Biotechnology;Brain;cell behavior;Cell Communication;cell injury;cell motility;Cell Physiology;Cell Survival;Cell Therapy;Cells;Chemotherapy and/or radiation;Clinical;Custom;cytokine;Cytokine Signaling;Cytoprotection;Data;delivery vehicle;design;Development;DNA Damage;Drug Delivery Systems;drug production;Drug Targeting;Encapsulated;Ensure;Equilibrium;ethylene glycol;Excision;Exhibits;FDA approved;fluorescence imaging;Formulation;Gelatin;Genetic Engineering;Glioblastoma;Growth;Health;Hour;hydrogel scaffold;Hydrogels;Image;Immune;Impairment;Implant;implantation;improved;in vivo;Kinetics;Lead;Lesion;Lipid Peroxidation;Liquid substance;Malignant neoplasm of brain;manufacture;manufacturing technology;mechanical properties;Mediating;Microscopic;migration;Modeling;Molecular Weight;monomer;mouse model;Mus;Nature;neoplastic cell;nerve stem cell;novel;novel strategies;Nude Mice;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Plant Resins;Polymers;porous hydrogel;Postoperative Period;pre-clinical;prevent;Printing;Process;Production;Property;Radiation;Recurrence;Recurrent disease;Recurrent tumor;Resolution;Safety;scaffold;Signal Transduction;standard care;standard of care;stem cell migration;stem cell therapy;Supporting Cell;Surface;Surgically-Created Resection Cavity;survival outcome;Survival Rate;Swelling;System;Techniques;Technology;temozolomide;Testing;Therapeutic;Therapeutic Agents;therapy outcome;Time;Treatment Efficacy;treatment strategy;Tropism;tumor;Tumor Suppression;Tumor-Derived;Tumorigenicity;Ultraviolet Rays;Variant;Western Blotting

PROJECT_TITLE: Novel Bioprinted Neural Stem Cell-Embedded Hydrogel Matrices for Enhanced Treatment of Glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Nutrition;Obesity;Physical Activity;Prevention;Sarcopenia

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Restriction of protein or specifically restricting the amino acid isoleucine results in drastic improvements in metabolic health and lifespan. However, adequate protein is required for muscle hypertrophy during exercise and frailty prevention during later life. During this F99/K00 award, I will examine the necessity of FGF21 for lifespan extension by examining the role of exercise and diet in the response of skeletal muscle to rapamycin while learning new skills, analytical techniques, and continuing to engage with the local science promoter.

PI_NAMEs: TRAUTMAN, MICHAELA  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Adherence;Adipose tissue;Age;Age Months;age-related disease;age-related muscle loss;Aging;aging population;Amino Acids;animal old age;Award;Biological;Biology of Aging;Biopsy Specimen;blood glucose regulation;Body Composition;Body Weight;Body Weight decreased;Branched-Chain Amino Acids;Caloric Restriction;Calories;Catabolism;CCI-779;Cell Physiology;clinical translation;Clinical Trials;cohort;Complex;Cyclic AMP-Dependent Protein Kinases;Development;Diabetes Mellitus;Diet;diet and exercise;dietary;Dietary Component;Dietary Intervention;dietary restriction;energy balance;Energy Metabolism;Essential Amino Acids;Exercise;exercise regimen;exercise training;experimental study;extend lifespan;Female;Fiber;fibroblast growth factor 21;fitness;frailty;FRAP1 gene;Funding;Genetic;Glucose;glucose tolerance;Goals;Health;healthspan;healthy aging;Hepatic;Histology;Hormones;Human;human old age (65+);improved;inhibitor;Insulin Resistance;Intervention;Isoleucine;Knock-out;Knowledge;late life;Learning;Leucine;life span;Longevity;Macronutrients Nutrition;male;Mediating;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;middle age;mimetics;Mitochondria;model organism;Molecular;Molecular Analysis;Monitor;mouse model;Mus;Muscle;muscle aging;muscle form;Muscle function;muscle hypertrophy;muscle strength;nutrition;Obesity;Older Population;Outcome;Participant;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Physiology;Population;Postdoctoral Fellow;preservation;prevent;Prevention;promoter;protein intake;Proteins;randomized, clinical trials;Recommendation;Regimen;Regulation;Research;Research Personnel;resistance exercise;Respiration;response;Role;sarcopenia;Science;SDZ RAD;side effect;Signal Transduction;Sirolimus;Site;Skeletal Muscle;skills;Supplementation;Techniques;Testing;Time;Tissue Banks;Tissues;Training;Valine;Work

PROJECT_TITLE: Metabolic regulation of healthy aging by diet, mTOR signaling, and skeletal muscle


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Stem cells are a critical aspect of aging as decreased stem cell capacity can contribute to age- related diseases, such as neural stem cells in the brain predisposing the hippocampus to Alzheimer’s. Therefore, understanding neural stem cell aging will provide opportunities to harness neural stem cells as a therapeutic for age-related cognitive decline and dementias like Alzheimer’s. This proposal will uncover central mechanisms of how neural stem cells decline with age and will reveal how to target them therapeutically.

PI_NAMEs: LEVI, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Ablation;Acceleration;Address;Adult;Age;age related;age related decline;Age-associated memory impairment;age-related disease;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease patient;Architecture;Bioinformatics;Biological;Biology;Brain;career development;Cell Count;Cell Cycle;Chromatin;Chromatin Remodeling Factor;clinical diagnosis;Cognition;Cognitive;cognitive reserve;Data;Dementia;dentate gyrus;Development;Disease;Disease Outcome;Drug Screening;Drug Targeting;Environment;epigenetic regulation;Etiology;experimental study;Functional disorder;gene network;Genes;genetic signature;genetic testing;Goals;hallmarks of aging;Hippocampus;HMGN2 Protein;Human;Immunohistochemistry;Impaired cognition;Impairment;improved;in silico;In Vitro;in vivo;Incidence;insight;Intervention;knock-down;large datasets;Learning;Lentivirus;Life;Link;Literature;Memory;Mentors;Microcephaly;Modernization;Moods;mouse model;Mus;nerve stem cell;neurogenesis;neuromechanism;neuropathology;Neurosciences;newborn neuron;novel;novel strategies;old mice;Open Reading Frames;Operative Surgical Procedures;overexpression;Parahippocampal Gyrus;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Play;Predisposition;preservation;Process;Proliferating;Proteins;reconstruction;regenerative;Regenerative capacity;Regulator Genes;Rejuvenation;resilience;Risk Factors;Role;Scientist;self-renewal;single-cell RNA sequencing;skill acquisition;skills;small hairpin RNA;stem cell aging;stem cell biology;stem cell fate;stem cell function;stem cell proliferation;stem cells;Sulindac Sulfone;Techniques;Telomerase;Testing;Therapeutic;Therapeutic Uses;Training;training opportunity;Work;Writing

PROJECT_TITLE: Uncovering Central Regulators of Neural Stem Cell Aging and Rejuvenation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Memory impairment is a core deficit accompanying many neurological disorders. This proposal will examine how discrete dopaminergic neuronal subsets modulate memory, from the sub-cellular compartment through neuronal circuit levels. These experiments will add to the knowledge base required for rational design of treatments for memory disorders.

PI_NAMEs: TOMCHIK, SETH M (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Anatomy;approach behavior;Arousal;Association Learning;avoidance behavior;Axon;Behavior;Behavioral;Brain;Brain Diseases;Brain region;Cells;Code;Complex;Cues;Cyclic AMP;Data;Dedications;Desire for food;Development;dopaminergic neuron;Drosophila genus;Drosophila melanogaster;experimental study;fly;Genetic;genetic manipulation;Goals;Image;in vivo;in vivo imaging;Individual;knowledge base;Learning;Mediating;Memory;Memory Disorders;memory encoding;Memory impairment;model organism;Molecular Biology;Mushroom Bodies;Negative Valence;Nervous System;Nervous System Disorder;neuronal circuitry;Neuronal Plasticity;Neurons;neuroregulation;neurotransmitter release;novel;Odors;optogenetics;Output;Pattern;Positive Valence;Process;Property;rational design;reinforcer;Resolution;response;Rewards;Role;Route;Sensory;sensory stimulus;Signal Transduction;Stimulus;Synapses;Testing;therapy design;tool;Work

PROJECT_TITLE: Dopaminergic circuit modulation of learning and arousal-mediated memory enhancement

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Caregiving Research;Clinical Research;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Pediatric;Substance Misuse;Telehealth

ORG_CITY: CHAMPAIGN

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Current state-of-the-art methods in assessing infant emotion regulation and infant-parent interaction—both critical to healthy brain and behavioral development—have been stymied by brief laboratory paradigms that are burdensome to families and limit ecological validity. Next-generation methods, including wearable sensing and machine learning approaches, promise to advance science and clinical practice among infants with prenatal substance exposures. Characterizing dynamic real-time processes of infant emotion regulation and infant- caregiver interaction (a) via multiple modalities, (b) across the day and (c) in the home will provide a level of granularity that has not been previously possible, while at the same time decreasing participant burden.

PI_NAMEs: HASEGAWA-JOHNSON, MARK ALLAN;MCELWAIN, NANCY L (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Achievement;Address;Adult;adverse outcome;analytical method;analytical tool;Architecture;automated assessment;Behavior;Behavioral;biobehavior;Brain;Cardiac;Caregivers;Categories;Child;Classification;clinical practice;Code;Complex;cost;Crying;Data;Data Set;data streams;deep learning;deep learning algorithm;deep learning model;Development;Devices;Dimensions;Distress;Early Diagnosis;Early Intervention;Electrocardiogram;emotion dysregulation;emotion regulation;Emotional;emotional experience;Emotions;Engineering;Environment;Environmental Risk Factor;Epidemic;Evaluation;experience;Exposure to;Face;Family;family burden;Fathers;fetal substance exposure;gaze;Helping to End Addiction Long-term;Home;Home environment;Hour;Household;Human;improved;Infant;Infant Behavior;innovation;Intervention;Label;Laboratories;Learning;Life;Link;Machine Learning;machine learning method;Manuals;Measures;member;Methods;microphone;Mind;Modality;Modeling;Monitor;Mothers;Motion;motion sensor;Motor Activity;multimodal data;multimodality;next generation;Opiate Addiction;Opioid;opioid misuse;opioid use disorder;Outcome;Overdose;Parents;Participant;Pattern;Persons;Phase;Physiological;Physiology;Play;Pregnancy;prenatal;prenatal exposure;Procedures;Process;protective factors;Protocols documentation;psychosocial;Public Health;remote assessment;Research;Research Priority;Risk;Sampling;Science;sensor;signal processing;Speech;Speed;stimulant use disorder;Stress;substance use;supervised learning;Technology;Testing;Time;time use;Training;training data;Transact;United States National Institutes of Health;Validation;Video Recording;virtual;virtual assessment;virtual visit;Visit;vocalization;wearable device;wearable platform;wearable sensor technology

PROJECT_TITLE: Validation of a Virtual Still Face Procedure and Deep Learning Algorithms to Assess Infant Emotion Regulation and Infant-Caregiver Interactions in the Wild

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-C(51)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: Project Narrative An estimated 6.5 million Americans age 65 and older are living with Alzheimer's disease (AD) today and this number could grow to 13.8 million by 2060 barring the development of medical breakthroughs to prevent, slow or cure AD. Current treatments for AD are symptomatic, with modest effect sizes and limited impact on longer- term disease outcomes. The goal of the proposal is to develop orally available and brain-penetrant neutral sphingomyelinase 2 (nSMase2) inhibitors mechanistically distinct from other therapeutic approaches, aiming at bringing a novel treatment option that can potentially delay or slow the progression of AD.

PI_NAMEs: RAIS, RANA ;SLUSHER, BARBARA STAUCH;TSUKAMOTO, TAKASHI  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: ABCB1 gene;absorption;Address;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;American;analog;aqueous;Area;Autopsy;Biochemical;Biogenesis;Biological Assay;Brain;Canis familiaris;Carbamates;Ceramides;clinical translation;Cognition;Cognitive deficits;Contralateral;dentate gyrus;Development;Disease Outcome;Dose;drug discovery;Drug Kinetics;efficacy evaluation;efficacy study;efficacy testing;Encapsulated;Enzymes;Excretory function;Exhibits;extracellular vesicles;Generations;Genes;Genetic;glial activation;Goals;Hippocampus;Human;human old age (65+);Hydrolysis;Impaired cognition;improved;In Vitro;in vivo;inhibitor;intercellular communication;Liver;Medical;Membrane;Metabolism;Modeling;Modification;Molecular;Monitor;mouse model;multidisciplinary;Mus;mutant;nanomolar;Neurology;neuron loss;nonhuman primate;novel;object recognition;Oral;Pathogenicity;Pathologic;Pathologic Processes;Permeability;Pharmaceutical Preparations;pharmacologic;Phosphorylcholine;Physiological Processes;Plasma;Play;pre-clinical;preclinical study;prevent;prototype;Pyridazines;Rattus;Reporting;Research Personnel;Role;scaffold;Series;Skeleton;small molecule;Solubility;Sphingomyelinase;Sphingomyelins;Structure-Activity Relationship;Study Section;tau aggregation;tau Proteins;Testing;Therapeutic;Therapeutic Agents;Toxic effect;Transgenic Mice;transgenic model of alzheimer disease;translational potential;vesicular release;Weight

PROJECT_TITLE: Development of neutral sphingomyelinase 2 (nSMase2) inhibitors for the treatment of Alzheimer's disease

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Substance Misuse

ORG_CITY: AUSTIN

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative High-quality mother-infant interactions set the stage for secure parent-child attachment, self-reliance, and children’s ability to flexibly solve problems and “bounce back” from difficulties. This constellation of behaviors reduces the risk of later developing problem behaviors, including substance use. The current proposal will develop algorithms that use data from wearable sensors to assess the quality of early mother-infant interactions objectively, automatically, and remotely in natural home environments, with the goal of developing tools to facilitate identification and prevention of early risks for substance use disorders.

PI_NAMEs: DE BARBARO, KAYA  (contact)

PROJECT_TERMS: Adolescence;Adolescent;Algorithms;automated assessment;Back;Behavior;caregiving;Characteristics;Child;Child Development;Childhood;Competence;craving;Crying;Data;Development;disorder prevention;Distress;Emotional;emotional functioning;Ensure;Evidence based intervention;externalizing behavior;Family;Feedback;flexibility;Future;Goals;Helping to End Addiction Long-term;Home;Home environment;improved;Infant;Informal Social Control;innovation;intergenerational;Intervention;mobile sensor;Modeling;Mothers;Motion;Opiate Addiction;Opioid;opioid misuse;Outcome;Parents;peer;Prevention;preventive intervention;Problem behavior;Problem Solving;Progress Reports;Protocols documentation;Public Health;Recommendation;Recording of previous events;remote assessment;Research;response;Risk;Risk Reduction Behavior;Role;Sampling;Schools;Secure;Security;self reliance;social;Spanish/English;Speed;Standardization;stressor;Substance abuse problem;substance use;Substance Use Disorder;success;Support System;Text;Time;tool;Training;training data;transmission process;United States National Institutes of Health;wearable data;wearable sensor technology

PROJECT_TITLE: Automated Assessment of Maternal Sensitivity to Infant Distress: Leveraging Wearable Sensors for Substance Use Disorder Prevention and Research


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This project aims to develop and test a fully-autonomous (no-human operator) CBT-based digital therapeutic for comorbid opioid use disorder (OUD) and internalizing (anxiety and depression) disorders that targets compulsive opioid use motivated by relief of unpleasant emotions. We will modify an existing digital therapeutic in the project's first phase and test it in a clinical trial in the second phase. The success of this project would provide a relatively cheap and easily scaled intervention for OUD based on a well-developed neuro-behavioral model of addiction.

PI_NAMEs: ANKER, JUSTIN JACK (contact);RINEHART, LINDA

PROGRAM_OFFICER_NAME: RAMEY, TANYA S

PROJECT_TERMS: addiction;Adherence;Adopted;Affect;Alcohol abuse;alcohol use disorder;Alcohols;Anxiety;Automobile Driving;Behavioral;Chronic;clinical efficacy;Clinical Trials;Cognitive;Cognitive Therapy;comorbidity;coping;Coping Skills;cost;design;Development;Devices;Diagnostic;diaries;digital;digital delivery;digital platform;digital treatment;Disease;drug of abuse;Drug usage;early onset;efficacy evaluation;Electronics;Emotions;Enrollment;experience;Feasibility Studies;Feedback;flexibility;follow-up;Goals;Health;Human;improved;Impulsivity;Individual;Internet;Intervention;Knowledge;meetings;Mental Depression;Methods;Modeling;Modification;negative affect;neuroadaptation;neurobehavioral;Neurobiology;novel therapeutics;opioid use;opioid use disorder;Outcome;Participant;Pathologic;Pharmaceutical Preparations;Phase;pilot test;pleasure;post intervention;Predisposition;Preparation;primary outcome;Process;programs;Protocols documentation;prototype;recruit;Regulatory Pathway;response;Safety;success;Symptoms;System;Testing;theories;Therapeutic;Therapeutic Intervention;therapeutic target;Time;tool;Training;Treatment outcome;usability;Validation;Work

PROJECT_TITLE: Autonomous Digital CBT Intervention for Opioid Use Disorder in Individuals with Co-Occurring Internalizing Disorders


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: IRVINE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is the most common cause of cognitive decline and there remains no known cause of sporadic cases and no cure. The transcription factor PPARd has recently emerged as a promising disease- modifying therapy for AD and is currently the focus of a Phase 2a clinical trial for mild-to-moderate AD. In this proposal, I will evaluate the mechanism of PPARd neuroprotection in microglia and assess the value of PPARd as a therapeutic target for AD.

PI_NAMEs: DEYELL, JACOB SAHAG (contact)

PROJECT_TERMS: Adipocytes;Affect;Agonist;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Amyloid beta-Protein;Anti-Inflammatory Agents;apolipoprotein E-4;Attenuated;Brain;brain cell;Cell model;Cells;Central Nervous System;Clinical Treatment;Clinical Trials;cytokine;Data;Dependence;Disease;disease phenotype;Down-Regulation;Exhibits;Experimental Autoimmune Encephalomyelitis;Exposure to;Family;Gene Activation;Gene Expression Regulation;Genes;genetic risk factor;Genetic Transcription;Goals;Homeostasis;Human;human induced pluripotent stem cells;Huntington Disease;Immune;Impaired cognition;improved;in vitro Model;in vivo;induced pluripotent stem cell;Inflammation;Inflammatory;inflammatory marker;insight;Ligands;Light;Link;Mediator;member;Membrane;Memory Loss;Microglia;Modeling;mouse model;Mus;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuroprotection;novel therapeutic intervention;Parkinson Disease;Pathogenesis;Peroxisome Proliferator-Activated Receptors;Phagocytes;Phase;Phenotype;Play;PPAR delta;Prevalence;Process;Production;PTEN gene;Quality of life;Research;risk variant;Role;SIRT1 gene;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutic target;Transactivation;Transcription Coactivator;transcription factor;Transcriptional Regulation;transcriptome sequencing;Translating;TYROBP gene;uptake;Wild Type Mouse;Work

PROJECT_TITLE: The Neuroprotective Role of PPAR-delta in Microglia


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Clinical Research;Disability Research;Hearing Loss;Pediatric

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative A lack of access to language during early childhood has lifelong affects not only on linguistic and communicative competence, but can cause cognitive delays, mental health difficulties, higher incidence of trauma, limited literacy, and lower quality of life. Globally, language exposure for deaf children begins at a variety of chronological ages and varies based on whether the local sign language is developed or emerging. The proposed studies will provide insight into how deaf people with various ages of language exposure use their cognitive and pragmatic resources to acquire and create language in a variety of settings.

PI_NAMEs: MILES, RACHEL ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: 5 year old;Adult;Affect;Age;age effect;American Sign Language;Auditory;biological age;Birth;career;Child;Child Language;Chronology;Cognitive;cohort;Communication;Communities;Competence;Comprehension;Cues;Data;Data Analyses;data communication;deaf;deafness;deprivation;Development;Devices;early childhood;Environment;Event;Exposure to;Fiji;Generations;graduate school;Hearing;human old age (65+);Incidence;Individual;Infant;insight;Knowledge;Language;Language Development;Linguistics;literacy;Mental Health;Modality;Oral;Parents;Participant;Pattern;Performance;Persons;Population;Process;Production;Productivity;Quality of life;Reporting;Research Personnel;Research Project Grants;Resources;Risk Factors;Robin bird;Sign Language;Stimulus;Structure;Training;Trauma;Vanuatu

PROJECT_TITLE: Effects of age of acquisition and of community on argument ordering


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Rehabilitation

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Navigation ability throughout the lifespan is critical to independent mobility and our quality of life. Here, we propose to study how we rely on our hearing along with our other senses to form a spatial map of our environment. Understanding how individuals with and without sensory impairments integrate their senses will help us learn how important it is to provide auditory health care with age, use auditory information during rehabilitation, and will help us decode how the brain perceives our world.

PI_NAMEs: SHAYMAN, COREY SCOTT (contact)

PROJECT_TERMS: Acute;Age;age related;Auditory;Back;behavioral study;Blindness;Brain;Central Scotomas;Chronic;Complex;Computer Models;Cues;Data;Echolocation;Environment;Equilibrium;Experimental Designs;Gait;Healthcare;healthy aging;Hearing;Homing;Human;Impairment;improved;Individual;Learning;life span;Locomotion;Maps;Methods;Modeling;Motion;Motion Perception;multisensory;Musculoskeletal Equilibrium;Noise;older adult;Participant;Pathology;Perception;Play;Quality of life;rehabilitation strategy;Rehabilitation therapy;Role;Scientist;Sensory;Sensory impairment;sensory integration;sensory substitution;sound;Source;Stream;Techniques;Update;Vestibular dysfunction;Vestibular loss;vestibular system;virtual reality;virtual reality simulation;Vision;Visual;Visual impairment;visual map;way finding;Weight;Work

PROJECT_TITLE: Multisensory integration of auditory cues for navigation


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

PHR: PROJECT NARRATIVE The proposed project responds to the National Institutes of Health, through the HEAL Initiative (RFA-DA-23- 051), solicitation for applications that test sustainable, scalable interventions to prevent opioid misuse and co- occurring conditions by intervening directly on social determinants of health (SDOH). The proposed project will take an important step toward addressing this need for research by evaluating the effectiveness of The Inclusive Skill-building Learning Approach (ISLA), an instructional and restorative alternative to exclusionary discipline, on the SDOH of education access and quality, and social and community context to prevent school exclusion and opioid and other substance misuse. This study has the potential to achieve meaningful outcomes including (a) reducing the use of exclusionary and racially discriminatory discipline practices, (b) improving inclusive teaching practices and student engagement, (c) improving student-teacher relationships and school climate, and (d) reducing student opioid and other substance misuse.

PI_NAMEs: NESE, RHONDA  (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: Academic achievement;Address;Administrator;Adopted;Behavior;Behavioral;black women;Communities;community engagement process;Cost Analysis;Criminal Justice;Development;Discipline;disparity reduction;education access;educational atmosphere;Educational process of instructing;effective intervention;Effectiveness;effectiveness evaluation;effectiveness trial;effectiveness/implementation hybrid;eighth grade;Emotional;Equity;Ethnic Origin;Exclusion;Funding;Future;Future Teacher;Gender;gender disparity;Goals;Helping to End Addiction Long-term;implementation evaluation;implementation outcomes;improved;Instruction;Intervention;intervention effect;junior high school;Leadership;Learning;Link;Mannans;Mediating;Mediator;member;Methods;minority children;Minority Men;multi-component intervention;Opioid;opioid misuse;Outcome;peer;prevent;Prevention;Preventive;preventive intervention;Problem behavior;Problem Solving;Process;Psychology;Public Health;Race;racial disparity;racial minority;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Risk Factors;school district;Schools;Science;skills;social;social determinants;social health determinants;Social Problems;Special Education;student participation;Students;substance misuse;substance use;Suspensions;System;teacher;Testing;Training;United States National Institutes of Health;universal prevention;usability;Youth

PROJECT_TITLE: Preventing School Exclusion and Opioid Misuse: Effectiveness of the Inclusive Skill-building Learning Approach (ISLA)


PHR: NARRATIVE Vocal communication hinges on the integration of auditory and motor systems in the brain, enabling the continuous use of auditory feedback to guide the motor actions that produce spoken language. In this proposal, we aim to understand the neurobiology of sensorimotor integration by simultaneously examining auditory and motor brain regions in European starlings while they sing and listen to song. This proposal outlines a novel approach for comprehending how the brain multiplexes and coordinates information across neuronal subpopulations, creating an opportunity to develop a network level understanding of neurobiological processes that substantiate language.

PI_NAMEs: MCPHERSON, TREVOR SUPAN (contact)

PROJECT_TERMS: Acoustics;Affect;Air Sacs;Algorithms;Anatomy;Animal Model;Area;Auditory;auditory feedback;auditory processing;Basic Science;Behavior;Behavioral;Biological Assay;Biological Models;bird song;Birds;Brain;brain computer interface;Brain region;career;Cell Nucleus;Chronic;Communication;Complex;computational neuroscience;Computing Methodologies;Coupled;Data;Data Analyses;Development;Dissociation;Electrophysiology (science);Engineering;European;expectation;experimental study;Foundations;Future;Generations;Goals;Human;Individual;insight;Investigation;Language;Link;Machine Learning;Measurement;Medial;Mediating;Medicine;Modeling;Motor;motor control;Names;neural;neurobiological mechanism;Neurobiology;Neurons;Neurosciences;novel;novel strategies;optogenetics;Organism;Output;Pathologic;Perception;Peripheral;Physiological;Population;Population Analysis;Population Dynamics;pressure;Process;Production;Recording of previous events;respiratory;Sensory;Signal Transduction;Site;skills;Songbirds;Source;Speech;Speech Perception;Structure;Sturnus vulgaris;System;Testing;theories;Time;tool;Training;vocal control;vocalization;Work

PROJECT_TITLE: Delineation of auditory-motor population dynamics underlying sensorimotor integration in the birdsong system


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE This project aims to validate remote testing methods for assessing infant cognitive development in underrepresented families. The project will reduce barriers to participation and contribute to our understanding of developmental trajectories and mechanisms across diverse environments and contexts, leading to improved precision for prevention and intervention efforts.

PI_NAMEs: BRITO, NATALIE HIROMI (contact)

PROJECT_TERMS: Address;Affect;Age Months;Area;Arousal;Attention;autism spectrum disorder;Back;Behavior;behavior measurement;Behavioral;Caregivers;Characteristics;Child Development;Childhood;Cognition;Cognitive;cognitive development;cognitive skill;cognitive testing;Complex;Computers;COVID-19 pandemic;Data;Data Collection;data collection methodology;Development;Electrocardiogram;Emotional;Environment;ethnic diversity;Eye;Family;family burden;gaze;handheld mobile device;Heart Rate;Helping to End Addiction Long-term;Home;Home environment;Household;improved;indexing;individualized prevention;Infant;infant monitoring;infant outcome;Intervention;Laboratories;Life;Link;Longitudinal Studies;Low income;Machine Learning;marginalized community;Measures;Memory;memory recognition;Methodology;Methods;Modality;multimodality;Neurocognitive;Neurodevelopmental Disorder;Neurosciences Research;non-verbal;open source;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Phenotype;Physiological;Physiology;Play;procedural memory;Process;Protocols documentation;Psychosocial Stress;Public Health;Race;recruit;Regulation;remote assessment;remote grading;Reproducibility;Research;Research Methodology;Response to stimulus physiology;Risk;Risk Marker;Role;rural residence;Sampling;Sampling Biases;Short-Term Memory;skills;sociodemographics;socioeconomics;Speed;sustained attention;Testing;United States National Institutes of Health;Validation;Visual attention;visual tracking

PROJECT_TITLE: Integrating eye-tracking and ECG methodologies for remote infant neurocognitive assessments in the home


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE INST FOR BIOMEDICAL/CLINICAL RES

ORG_STATE: WA

PHR: Alzheimer’s disease and related dementia disorders are incurable aging related brain diseases causing severe disability and death around the world. RNA binding by tau contributes to pathological tau protein deposition in the brain neurons of Alzheimer’s disease patients leading to neuronal dysfunction and neurodegeneration. Completion of this project will advance the field by illuminating the molecular mechanisms of abnormal tau function through RNA binding and measure the influence of tau RNA complexes on neurodegeneration.

PI_NAMEs: KRAEMER, BRIAN C. (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Affinity;aging related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid;Automobile Driving;Binding;Biological Models;Brain;Brain Diseases;brain tissue;Caenorhabditis elegans;Cells;Cessation of life;Characteristics;Clinical Trials;Cognitive;Complex;Data;Dementia;Deposition;Diagnostic;disability;Disease;Frontotemporal Lobar Degenerations;Functional disorder;Genes;Homeostasis;Human;Impaired cognition;in vivo;Intervention;Knowledge;Lesion;Maps;Measures;Mediating;Mediator;Messenger RNA;Microtubule Polymerization;Microtubule Stabilization;Microtubules;Molecular;Molecular Conformation;Molecular Weight;Monitor;Monoclonal Antibodies;mouse model;Nerve Degeneration;Neuronal Dysfunction;Neurons;neuropathology;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;Poly(A) Tail;Poly(A)+ RNA;polyadenylated messenger RNA;pre-clinical;Predisposition;preservation;Property;Protein Isoforms;Proteins;Reporter;RNA;RNA Binding;RNA Recognition Motif;RNA-Binding Proteins;Role;Severities;Specificity;symptom treatment;System;targeted treatment;tau aggregation;tau conformation;tau function;tau mutation;tau Proteins;Tauopathies;Therapeutic;therapeutic development;tool;Toxic effect;Transgenes;Tubulin;Work

PROJECT_TITLE: Formation of Tau RNA Complexes disrupts tau function and drives tau neuropathology

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]