NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

PI_NAMEs: KOESTLER, DEVIN CHARLES (contact)

PROJECT_TERMS: Address;Artificial Intelligence;Big Data;Bioinformatics;Biomedical Research;Biometry;Businesses;Characteristics;Clinical;clinically actionable;Collaborations;Communication;Computer software;cost effective;Creativeness;Custom;Data;data management;data modeling;Data Science;Data Scientist;data visualization;deep learning;Development;Environment;experience;Funding;Goals;Health;High Performance Computing;Image;improved;Individual;individual patient;individualized medicine;Infrastructure;Institution;Investments;Kansas;member;metabolomics;Methodology;Methods;Mission;Molecular Epidemiology;molecular modeling;multiple omics;Nature;novel;operation;Outcome;Patients;Pattern;Phase;Positioning Attribute;precision medicine;Procedures;Proteomics;Publishing;Quality Control;recruit;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Science;Secure;Services;skills;statistical and machine learning;success;support tools;targeted treatment;Technical Expertise;Technology;tool;Translating;Treatment Protocols;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: Quantitative 'Omics Core


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Precision Medicine

ORG_CITY: KANSAS CITY

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PI_NAMEs: GODWIN, ANDREW K. (contact)

PROJECT_TERMS: Area;base;biobank;Biological;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker discovery;biomarker identification;biomarker validation;Biomedical Research;Biopsy;Blood;Body Fluids;Businesses;career;Caring;Centers of Research Excellence;Cerebrospinal Fluid;Chronic;Clinical;Collection;Core Facility;Correlation Studies;cost effective;Data;design;Detection;Disease;disorder subtype;Ensure;Environment;Environmental Risk Factor;Ethics;Faculty;Fee-for-Service Plans;frontier;Funding;Future;Genetic;Goals;Health Personnel;Healthcare;Human;improved;improved outcome;Individual;individual response;individualized medicine;Infrastructure;innovation;Institution;instrumentation;Intervention;Kansas;Laboratories;Lavage;lifestyle factors;Liquid substance;Longevity;Measurable;Medical center;member;Mission;Molecular;Molecular Biology;multidimensional data;new technology;Nose;operation;Outcome;Patient Care;Patient Monitoring;patient population;Patient-Focused Outcomes;Patients;Phase;Pilot Projects;precision medicine;programs;prospective;relative cost;Research;Research Personnel;Research Project Grants;Research Support;Resources;Sampling;Science;Scientist;Secure;Services;side effect;Solid;Specimen;success;Technical Expertise;Testing;Time;Tissues;Translating;Translational Research;treatment effect;tumor;Universities;unnecessary treatment;Update;Urine

PROJECT_TITLE: Biobanking and Biovalidation Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (C2)]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Lung;Orphan Drug;Precision Medicine;Pulmonary Fibrosis;Rare Diseases;Rheumatoid Arthritis

PI_NAMEs: MATSON, SCOTT MICHAEL (contact)

PROJECT_TERMS: Antibodies;Area;Autoantibodies;Autoimmune;biobank;Biochemical;Biological;Biological Markers;biomarker identification;biomarker validation;Biopsy;Blood;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Centers of Research Excellence;Cessation of life;Chronic lung disease;Clinical;clinical phenotype;clinical practice;cohort;Data;Development;Diagnosis;differential expression;Disease;effective therapy;Fibrosis;fibrotic lung;follow-up;Funding;Future;Gene Expression;Gene Proteins;Generations;Genes;health related quality of life;Human;idiopathic pulmonary fibrosis;improved;Individual;Inflammation;innovation;insight;interest;Intervention Trial;Kansas;Label;Link;Liquid substance;Lung;Lung Diseases;lung injury;Lung Transplantation;lung volume;Malignant Neoplasms;Mass Spectrum Analysis;Medical;metabolomics;Methods;Modernization;Molecular;Network-based;novel;novel marker;novel strategies;novel therapeutics;Operative Surgical Procedures;Pancreas;Participant;Pathway interactions;Patients;Peripheral;personalized diagnostics;Phase;phase 1 study;Phenotype;Placebos;precision medicine;Process;Prognosis;prospective;Proteins;Proteomics;Quality of life;Randomized, Controlled Trials;Rare Diseases;recruit;Research;Resources;response;Rheumatoid Arthritis;Role;Sampling;Serum;Solid;Source;Structure of parenchyma of lung;survival outcome;System;Therapeutic Intervention;Time;Tissue Sample;Tissues;tool;transcriptomics;treatment response;trend;Validation

PROJECT_TITLE: The Role of Chronic Lung Disease in the Generation of Rheumatoid Arthritis Associated Antibodies


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Prevention;Schizophrenia;Serious Mental Illness;Sleep Research

PI_NAMEs: VEATCH, OLIVIA J (contact)

PROJECT_TERMS: Adult;Area;Behavior;biobank;Biochemical Genetics;Biochemical Pathway;Biological Specimen Banks;biomarker validation;Brain;brain control;Brain Diseases;Brain region;brain tissue;Caring;Centers of Research Excellence;Cerebral cortex;Clinical;Communities;comorbidity;Computational Technique;Data;Data Set;Development;Diagnosis;differential expression;Disease;Drug Targeting;Early Diagnosis;Early Intervention;effective therapy;Electroencephalography;Female;Functional disorder;Gene Expression;Genes;Genetic;genetic architecture;Genetic Risk;Genetic Variation;Genome;genome sequencing;genomic data;Genomics;Goals;Health;Homeostasis;Human;human data;improved;Individual;Investigation;Kansas;Knowledge;life span;male;Medical;Medical center;Mental Health;Mentors;Molecular;Multiomic Data;Nervous System Physiology;neurodevelopment;non rapid eye movement;novel;Outcome;Patients;pleiotropism;precision medicine;protein expression;protein protein interaction;Proteins;Proteome;Proteomics;Psychiatry;Psychoses;Race;Reporting;Research;Research Personnel;Resources;Risk;risk prediction;sample collection;Schizophrenia;Severities;Sleep;sleep behavior;Sleep Disorders;Sleep disturbances;sleep quality;sleep regulation;sleep spindle;Sleeplessness;small molecule;Specimen;Structure;success;Symptoms;Synaptic plasticity;Testing;Thalamic structure;trait;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;United States National Institutes of Health;Universities;Variant;whole genome;Work

PROJECT_TITLE: Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep Disturbances


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention;Radiation Oncology;Rare Diseases

PI_NAMEs: BUR, ANDRES MARTIN (contact)

PROJECT_TERMS: Address;Adopted;Aftercare;Atlases;biobank;Biological;Biological Markers;biomarker identification;biomarker validation;Biomedical Engineering;Biopsy;cancer genomics;cancer imaging;Cancer Model;Characteristics;chemoradiation;Clinical;Clinical Trials;clinically relevant;Collaborations;community engagement;contrast enhanced computed tomography;Core Facility;Data;Data Set;Databases;design;Development;digital;Disease Progression;Early identification;Early Intervention;Early treatment;Ensure;Epidermal Growth Factor Receptor;Feasibility Studies;Formalin;Foundations;Future;Gene Expression;Genes;Genetic Transcription;Genomics;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;high risk;HPV-negative head and neck cancer;Human Papillomavirus;Hypoxia Pathway;Image;improved;Individual;Institution;Investigation;Kansas;Liquid substance;Machine Learning;machine learning model;Malignant Neoplasms;MAP Kinase Gene;Measurement;Measures;Mediating;Medical;Medical center;Methodology;Modeling;Molecular;multidisciplinary;Multiomic Data;multiple omics;Neck;neoplastic cell;Network-based;neural network;novel;Operative Surgical Procedures;Outcome;outcome prediction;outreach program;Papillomavirus;Paraffin Embedding;Pathologic;patient biomarkers;Patient Care;patient engagement;patient oriented;patient outreach;Patient-Focused Outcomes;Patients;personalized care;Phenotype;Plasma;precision medicine;Precision medicine trial;Precision therapeutics;Prediction of Response to Therapy;prognostic;Prognostic Marker;prognostic model;Progression-Free Survivals;prospective;Protein Kinase;quantitative imaging;Radiogenomics;radiological imaging;radiomics;Recurrence;Research;Resources;Sampling;survival prediction;targeted treatment;Testing;The Cancer Genome Atlas;The Cancer Imaging Archive;Tissue Embedding;Training;transcriptome;transcriptomics;treatment duration;Treatment Failure;Treatment outcome;treatment response;tumor;tumor DNA;tumor progression;Tumor Tissue;Tumor-Derived;Universities;Work

PROJECT_TITLE: Radiogenomic Predictors of Treatment Response in Head and Neck Squamous Cell Carcinoma


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome;Microbiome;Ovarian Cancer;Precision Medicine;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: MAHONEY, DIANE E (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Abdomen;Bacteria;Benign;biobank;Biological Assay;Biological Markers;biomarker validation;Biomedical Engineering;Body Regions;cancer initiation;candidate validation;carcinogenesis;career preparation;Cells;Centers of Research Excellence;Characteristics;Clinical;clinical diagnosis;Clinical Markers;clinical practice;Collaborations;Communicable Diseases;Complex;Data;Detection;Development;Diagnosis;digital;Disease;Disease Pathway;Early Diagnosis;early screening;Epithelial Cells;Epithelial ovarian cancer;extracellular vesicles;genome sequencing;Goals;gut bacteria;gut microbiome;gut microbiota;Gynecologic;High Risk Woman;Histologic;Histology;Human Microbiome;innovation;Investigation;Kansas;Knowledge;liquid biopsy;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;microbial;microbiome;Molecular;Molecular Analysis;molecular targeted therapies;Mucous Membrane;novel;novel strategies;Nucleic Acids;Ovarian;ovarian neoplasm;Ovarian Serous Adenocarcinoma;paracrine;pathobiont;Pathologic;Pathology;Pathway interactions;Pattern;Pelvis;Plasma;practice setting;precision medicine;precision oncology;programs;Reproducibility;Research;Ribosomal RNA;Role;rRNA Genes;Sampling;Scientist;screening;Screening for Ovarian Cancer;Signal Transduction;Site;Solid Neoplasm;Source;stool sample;Survival Rate;Testing;Thinking;tumor;tumor microbiome;tumor microenvironment;tumor progression;tumorigenesis;vesicular release;Woman

PROJECT_TITLE: Integrative Analysis of the Blood Plasma and Tumor Microbiome: A Novel Approach to Liquid Biopsy Screening for Early Epithelial Ovarian Cancer Detection


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: PROJECT NARRATIVE The ability to treat disorders and injuries of the nervous system requires a detailed understanding of the molecules, cells, and circuits that drive behavior. Modern neuroscience techniques for analyzing brain function across these scales can generate increasingly large and complex data sets, requiring sophisticate quantitative tools and reasoning to extract biological meaning. We propose a new postdoctoral training program at the Salk Institute: “Quantitative Neuroscience Spanning Molecules, Cells, Circuits, and Behavior” that will provide the next generation of neuroscientists with the research experience, quantitative literacy, and professional skill sets necessary to tackle daunting challenges in neuroscience, launch productive careers, and create diverse and supportive research environments.

PI_NAMEs: CALLAWAY, EDWARD M;PFAFF, SAMUEL L. (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Behavior;Cells;Neurosciences

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-R (15)]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Racial/ethnic disparities in obesity among youths persist. The proposal aims to elucidate the influence of both neighborhood and interpersonal discrimination on the risk of obesity among children and adolescents. The study will provide a comprehensive examination for how discrimination impacts youth, shedding light on (1) the behavioral processes involved, (2) protective factors that may mitigate the risk, and (3) the broader implications for racial/ethnic disparities in obesity that can be extrapolated to the entire U.S. population.

PI_NAMEs: CUEVAS, ADOLFO  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Acceleration;Address;Adolescent;Adolescent obesity;Affect;Area;Behavior;Behavioral;Biometry;Black race;Body mass index;Brain;Buffers;Child;Chronic Disease;Clinical;cognitive development;cohort;Community Healthcare;Data;Diet;Dimensions;Discrimination;Disparity;Education;effective intervention;ethnic difference;ethnic disparity;Ethnic Origin;Etiology;Exhibits;Exposure to;family support;Genetic;Goals;Growth;Health;Health behavior;Health behavior and outcomes;health disparity;Healthcare;healthy weight;high risk;Hispanic;Housing;Individual;Intervention;Life;life span;Light;Mediating;Modeling;mortality;Neighborhoods;Not Hispanic or Latino;novel;Obesity;Obesity associated disease;obesity in children;obesity risk;Outcome;Physical activity;Play;Population;Populations at Risk;Prevalence;Prevention;Process;protective factors;psychosocial;psychosocial resources;Race;racial difference;racial discrimination;racial disparity;Reduce health disparities;Research;Risk;risk mitigation;Role;Sampling;school environment;Shapes;sleep quality;social determinants;Social Environment;Socioeconomic Status;Testing;Time;Treatment/Psychosocial Effects;tv watching;Twin Multiple Birth;United States;waist circumference;Work;Youth

PROJECT_TITLE: The Impact of Discrimination on Anthropometric Outcomes: An Analysis of the Adolescent Brain Cognitive Development (ABCD) Study

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative (3 sentences): Native American groups are among the most under-represented groups across STEM disciplines, including Aging Sciences. This disparity has arisen from a number of historical and institutional challenges. To meet this challenge, we propose the creation of a research education program to support students from tribal colleges and universities with high NA/AI student populations in developing scientific literacy, research, and laboratory skills focused on aging.

PI_NAMEs: BRINTON, ROBERTA EILEEN;RODGERS, KATHLEEN E. (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Accountability;Address;Aging;aging related;Alaska Native;Alaska Native population;American Indian Population;American Indians;animation;Arizona;Attention;Awareness;Bachelor's Degree;Biomedical Research;Caring;college;Communities;community involvement;cultural competence;Cultural Diversity;Degree Completion;design;Development;Disparity;Doctor of Philosophy;Education;education research;Educational workshop;Elderly;Elements;Ethnic Origin;Evaluation;experience;Face;financial literacy;Funding;Goals;graduate school;graduate school preparation;healing;Health;health disparity;Health Professional;higher education;Hour;Individual;Institution;interest;intergenerational;Internships;Journals;Knowledge;Laboratories;Lead;Leadership;Learning;Link;literacy;Literature;Medicine;meetings;Mentors;Methods;Minority;Modeling;Native American community;Native American population;Native Americans;Navajo;Nervous System Disorder;Neurosciences;Oral;Pattern;Persons;Philosophy;Population;Positioning Attribute;preservation;Principal Investigator;programs;Psyche structure;psychoeducation;recruit;Research;research and development;Research Personnel;resilience in aging;responsible research conduct;Schools;Science;Science, Technology, Engineering and Mathematics;scientific literacy;Series;Site;skills;social stigma;Societies;sound;Spirituality;STEM career;STEM field;Stereotyping;Stroke;student retention;Students;summer program;summer research;Support System;System;teacher;Technology;Time;Training;Training Programs;tribal college;Trust;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;virtual;Vocational Guidance

PROJECT_TITLE: Diversity in Research Education in Aging Medicine and Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (J2)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dietary Supplements;Nutrition

ORG_DEPT: BIOLOGY

ORG_NAME: HERBERT H. LEHMAN COLLEGE

PHR: PROJECT NARRATIVE Cadmium is a food chain contaminant that is present in crop species (particularly cereal grains like wheat and rice), at concentrations that sometimes exceed safe limits for human consumption and has significant neurotoxicological effects at low doses especially in pediatric population. Toxic trace heavy metals such as cadmium have chemical properties similar to essential micronutrients such as zinc (Zn) and are generally transported in plants by transporters of essential micronutrients. The overall goal of this research is to elucidate the transport of cadmium from root to seed in order to improve zinc density in food crops like wheat and concomitantly reduce the possible dietary exposure to cadmium.

PI_NAMEs: SANKARAN, RENUKA  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: absorption;Address;Adult;Adverse effects;Affect;Agriculture;American;Biodiversity;Biological Assay;Biological Availability;bone;Bone Diseases;Breeding;Cadmium;Carcinogens;Cereals;chemical property;Child;Childhood;Chromatography;cognitive ability;Consumption;Data;density;Diet;dietary;Dose;early life exposure;Environmental Health;Exposure to;Fertilization;Food;Food Chain;Gene Expression;Genes;Goals;Grain;Health;Heavy Metals;Human;improved;in utero;In Vitro;Inductively Coupled Plasma Mass Spectrometry;Infant Food;Iron;Kidney;Kidney Failure;Knowledge;Malignant Bone Neoplasm;Measures;metal poisoning;Metals;micronutrient deficiency;Micronutrients;Minerals;Molecular;Movement;neurodevelopment;neurotoxicology;non-smoking;Nutrient;Nutritional;Outcome Study;Physiological;Plants;Population;Process;Productivity;Research;response;retention rate;Rice;Soil;Source;Tissues;toxic metal;transcriptome sequencing;United States;uptake;Variant;Wheat;Zinc

PROJECT_TITLE: Elucidating mechanisms that differentiate between uptake of toxic heavy metals and beneficial micronutrients in food crops

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-A (SU)]


NIH_SPENDING_CATS: Pediatric

ORG_CITY: UNION

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: KEAN UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The Kean University U-RISE Trainee Pathway will expand and enhance recruitment and training of undergraduate students in the conduct of rigorous, responsible research in biomedical fields. The goal is to increase the diversity and number of students graduating with bachelor of science degrees, entering and graduating from PhD programs, and joining the research workforce. Strengthening the biomedical research workforce will speed medical progress, ultimately improving healthcare for all.

PI_NAMEs: CONIGLIO, SALVATORE JOHN;NIEPIELKO, MATTHEW GENE;SWINTON, DERRICK  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Area;Biological Sciences;Biology;Biomedical Research;Biotechnology;Boston;Career Choice;Chemistry;cohort;computer science;Data;Development;Doctor of Philosophy;Entrepreneurship;equity, diversity, and inclusion;experience;Faculty;field study;Financial Support;Fostering;Graduate Education;Grant;high school program;High School Student;Home;Incubators;Industry;Institution;lens;Mathematics;member;Mentors;Minority-Serving Institution;Modeling;Pathway interactions;Phase;programs;recruit;Research;Research Institute;Research Project Grants;responsible research conduct;Schools;Science;Self Efficacy;skills training;social capital;Students;Technology;Training;undergraduate student;Underrepresented Minority;Underrepresented Populations;Universities

PROJECT_TITLE: Kean University U-RISE Trainee Pathway (KUTP)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: PEMBROKE

ORG_NAME: UNIVERSITY OF NORTH CAROLINA AT PEMBROKE

ORG_STATE: NC

PHR: The UNCP U-RISE program aims to prepare undergraduate students underrepresented in the sciences for admission into biomedical PhD degree programs. Through mentored research experiences, career exploration, and guidance from faculty research mentors, program staff and peer mentors, trainees will gain the skills and experience needed to complete graduate degrees in STEM fields. This program will prepare a diverse cohort of biology, chemistry and physics majors with the skills to successfully complete their PhD degrees and successfully transition to careers in the biomedical research workforce.

PI_NAMEs: ALEXANDER, COURTNEY CARROLL (contact);POAGE, ROBERT E;SMITH, RACHEL B.

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Behavioral Sciences;Biology;Biomedical Research;career;career development;Career Exploration;Chemistry;cohort;Communication;coping;Development;Development Plans;disadvantaged background;disadvantaged student;Educational workshop;Elevator;Evidence based intervention;experience;experimental study;Faculty;Future;Goals;Individual;Institution;Leadership;Mentorship;Minority-Serving Institution;Modeling;Monitor;Native Americans;North Carolina;Oral;peer;Physics;posters;programs;Reading;recruit;Research;research faculty;Research Training;resilience;Rural;Safety;Science;Self Care;Self Efficacy;skills;Source;Students;summer research;Training;Training Programs;Universities;Writing

PROJECT_TITLE: U-RISE at the UNC Pembroke


NIH_SPENDING_CATS: Genetics

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: Project Narrative The double helix DNA structure was discovered seven decades ago, but our understanding about how DNA is replicated is still limited, particularly in eukaryotic cells. Recent advance in cryo-EM has made it feasible to study the structure and molecular mechanism of chromosome replication as carried out by the coordinated efforts of several molecular machines such as the replicative CMG helicase, the polymerase-primase complex Pol α, and the leading and lagging strand DNA polymerases Pol ε and Pol δ. Because replication errors and insufficient repair of these errors underlie many human diseases such as cancers, studying the molecular mechanism of eukaryotic DNA replication is important for fundamental biology as well as for understanding of and developing treatment for cancers and many other diseases.

PI_NAMEs: LI, HUILIN  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Archaea;Architecture;ATP phosphohydrolase;Bacteria;Bacteriophage T4;Binding;Biology;cancer therapy;Cell Cycle;cell growth;chromosome replication;Closure by clamp;Complex;Cryoelectron Microscopy;Disease;DNA;DNA biosynthesis;DNA Primase;DNA replication fork;DNA Structure;DNA-Directed DNA Polymerase;ds-DNA;Enzymes;Eukaryotic Cell;Funding;G1 Phase;helicase;human disease;In Vitro;Life;Malignant Neoplasms;Molecular;Molecular Machines;Nucleosomes;Nucleotides;origin recognition complex;Polymerase;Pre-Replication Complex;Process;Proliferating;reconstitution;recruit;repaired;Replication Error;Replication Origin;Research;Resolution;RNA primers;Specificity;Structure;success;tumorigenesis;Visualization;Yeasts

PROJECT_TITLE: Structural mechanism of DNA replication

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Advancements in basic, translational and clinical research on rheumatological diseases have culminated in the dawn of precision medicine that aims to deliver big-data-informed, pathway-specific targeted diagnostic, prognostic and therapeutic strategies with enhanced accuracy, efficacy and reduced toxicity. This long- standing UCSD Rheumatology T32 program will also focus on expanding collaboration with our community. The proposed renewal of the UCSD T32 program will provide resources and infrastructure to recruit and train a new generation of postdoctoral as well predoctoral students early in their research careers.

PI_NAMEs: FIRESTEIN, GARY S;GUMA, MONICA  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Grant;Research Training;Rheumatism

PROJECT_TITLE: Rheumatic Diseases Research Training Grant

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE This renewal application seeks continued support for the training of Pre-doctoral and Post-doctoral students in the Neurobiology of Aging and Alzheimer’s Disease. We aspire to train the next generation of research scientists with an enhanced emphasis cutting edge technology, team science and large collaborative initiatives in multiple aspects of basic and translational neuroscience to delay and treat age-related cognitive decline and neurodegenerative diseases. A strong foundation in basic science, tight integration with clinical research, and opportunities for translational research goals will assure a steady source of new talent that will stimulate the field and generate novel approaches to these problems.

PI_NAMEs: STARK, CRAIG E;TENNER, ANDREA JOAN (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TITLE: Training in the Neurobiology of Aging and Alzheimers Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (J2)]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: LAS CRUCES

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: PROJECT NARRATIVE The NMSU U-RISE will contribute to broadening participation and retention of undergraduate students from Historically Excluded Communities (HECs) in research areas of interest to the National Institutes of Health. To accomplish this goal, NMSU has assembled a two-year research education program for Junior- level students comprised of a) a thoroughly immersive research program, b) an inclusive and affirming educational seminar series built into students’ curriculum, c) a mentorship education that promotes faculty- student relationships to be grounded in open communication, support and allyship, and d) expansion of research experiences to NMSU students in the agricultural sciences and social-public health fields at NMSU. This program seeks to strengthen inclusive, equitable, and diverse scientific environments at NMSU that will welcome different perspectives, spark the most innovative ideas, and improve our research education programs for current and future scientists from HECs.

PI_NAMEs: MARIN, MERRANDA ;UNGUEZ, GRACIELA ALEXANDRA (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: U-RISE at NMSU


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE To contribute to building a diverse pool of well-trained scientists in the biomedical research workforce, the University of Alabama at Birmingham (UAB) Maximizing Access to Research Careers (MARC) Program will provide up to two years of mentored research, education, and career development activities for ten undergraduates (scholars) every two years (matriculating five each year) from groups underrepresented in biomedical research for preparation and transition into PhD or MD-PhD programs. Scholars will be matched with experienced, funded UAB faculty preceptors, who will mentor them and provide high quality research experiences in biomedical sciences. The program curriculum will be tailored to each scholars’ needs to prepare them for success in doctoral training, and will address objectives that include critical thinking, quantitative skills development, scientific writing, presentation skills, ethics in research, networking, research career and exposure readiness, and preparation for graduate school, with scholars’ progress assessed quarterly.

PI_NAMEs: GAVIN, CRISTIN F;GRAY, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Advisory Committees;Alabama;Biomedical Research;career;career development;Clinical;Critical Thinking;Development Plans;Disabled Persons;disadvantaged background;Disparity population;Doctor of Philosophy;Education;Educational Curriculum;Ethics;ethnic minority;Evaluation;experience;Exposure to;Faculty;Funding;Goals;graduate school preparation;Individual;Institution;Interdisciplinary Study;K-Series Research Career Programs;Laboratory Research;Leadership;matriculation;member;Mentors;Mission;Participant;Pathway interactions;Preparation;Program Evaluation;programs;racial minority;Readiness;Research;Research Training;Science;Scientist;Site;skill acquisition;skills;success;Training;Training Programs;undergraduate student;Underrepresented Populations;underserved area;Universities;Writing

PROJECT_TITLE: MARC at the University of Alabama at Birmingham

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric - AIDS;Prevention;Telehealth;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: To date, no intervention has proven efficacious for improving the low rate of undetectable VL in women with HIV who engage in sex work. We propose a clinical trial to test the effectiveness of Motivation Matters!, a promising mHealth intervention for improving the rate of undetectable viral load in this key population. In parallel, we will conduct implementation research to examine intervention fidelity, feasibility, acceptability, appropriateness, cost, patient-centeredness, satisfaction, and engagement.

PI_NAMEs: KIMANI, JOSHUA ;MCCLELLAND, RAYMOND SCOTT (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adherence;Adverse event;Affect;African Women;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Area;arm;Behavior;Behavioral;budget impact;Caring;Client;clinical practice;Clinical Trials;Collaborations;cost;Data;Development;Disclosure;Effectiveness;effectiveness testing;effectiveness/implementation trial;Emergency Situation;Evaluation;Evidence based intervention;Funding;General Population;Graduation Rates;Health;Health system;HIV;HIV/AIDS;Hybrids;implementation framework;implementation outcomes;implementation research;improved;Incidence;incremental cost;Individual;Information Theory;Intervention;Intervention Trial;Joints;Knowledge;Logic;Measures;Methods;mhealth interventions;Modeling;Motivation;NIH Office of AIDS Research;Outcome;Participant;Pathway interactions;patient engagement;patient oriented;Population;preference;Prevention;Process;programs;Public Health;Questionnaires;Randomized, Controlled Trials;Relative Risks;Reporting;Research;Research Priority;Safety;satisfaction;scale up;Services;sex;skills;standard of care;Stigmatization;theories;therapy adherence;treatment arm;treatment as prevention;Treatment outcome;United Nations;uptake;Viral Load result;Woman;Work

PROJECT_TITLE: Hybrid Type-1 Effectiveness-Implementation Trial of Motivation Matters! A Theory-Based mHealth Intervention to Support Early Antiretroviral Adherence in HIV+ African Women Who Engage in Sex Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-S (03)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Contraception/Reproduction;Diabetes;Maternal Health;Nutrition;Obesity;Pregnancy;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: HOWARD UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Type 2 diabetes mellitus (T2D) with increasing prevalence presents a heavy socioeconomic burden, but the root cause of T2D remains unclear. We propose to understand the role of placenta mitochondria in predisposing T2D in offspring in women with gestational diabetes mellitus (GDM), using human tissues as well as a novel mouse GDM model. The expected findings will yield important insights into the study of placental mitochondrial dysfunction, and into potential therapeutic means for GDM and GDM predisposed T2D in offspring during maternal pregnancy, thus breaking the vicious cycle of diabetes and pregnancy.

PI_NAMEs: GAO, HAIJUN  (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Adult;Affect;Animal Model;Beta Cell;Biological Assay;Body fat;care systems;Catabolism;Cell Proliferation;Cells;comparison control;Control Groups;cytotrophoblast;design;Development;Diabetes Mellitus;Disease;Economic Burden;epidemiology study;Fetus;genetic manipulation;Gestational Diabetes;Glucose;Glucose Intolerance;glucose tolerance;Glucose tolerance test;Goals;Health;Health system;HRK gene;Human;human tissue;Hydrogen Peroxide;Immunofluorescence Immunologic;Impairment;in vivo evaluation;Individual;insight;Insulin Resistance;insulin secretion;Islets of Langerhans;knock-down;Knock-out;Lentivirus;Ligation;lipid metabolism;Lipids;Magnetic Resonance Imaging;male;Measures;Mediating;Mediator;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Mitochondria;mitochondrial dysfunction;Modeling;Mothers;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;offspring;Oleic Acids;Organ;Pancreas;Pathway interactions;Phenotype;Placenta;placental protein 3;Placentation;Play;Pregnancy;pregnant;Prevalence;Prevention;Process;Production;Role;small hairpin RNA;socioeconomics;Stains;Structure of beta Cell of islet;Testing;Therapeutic;Time;Tissues;Transfection;Transmission Electron Microscopy;trophoblast;Weaning;Western Blotting;Woman

PROJECT_TITLE: Roles of Placental Mitochondria in the Vicious Cycle of Diabetes and Pregnancy


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Addiction is a major determinant of mortality and societal burden. Despite high public health significance of the problem, treatment and prevention of drug addiction are only modestly effective. The UCLA Training Program in the Translational Neuroscience of Drug Addiction (TNDA) provides multidisciplinary training that spans the fundamental bases of addiction from the genome to neural phenotypes and ultimately the syndrome of addiction, with particular strength in molecular and cellular, behavioral and systems, and cognitive and clinical neuroscience.

PI_NAMEs: RAY, LARA A.;WASSUM, KATE M (contact)

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: Drug Addiction;Training Programs;translational neuroscience

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Pain Research;Substance Misuse

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative: Pain and substance use disorders (SUDs) are highly prevalent, commonly co-occurring and confer a tremendous toll on society. There is an urgent need to train interdisciplinary researchers who can better characterize these important conditions and translate discoveries to safe and effective treatments. The aim of this postdoctoral training program is to develop the next generation of scientific leaders in pain and SUDs.

PI_NAMEs: MACKEY, SEAN C (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Interdisciplinary Study;Pain;Research Training;Substance Use Disorder

PROJECT_TITLE: Interdisciplinary Research Training in Pain and/or Substance Use Disorders


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: BIDDEFORD

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NEW ENGLAND

ORG_STATE: ME

PHR: Project Narrative While current therapeutic approaches for epilepsy primarily focus on symptom management and seizure suppression, there remains a critical gap in targeting the underlying processes of brain reorganization (epileptogenesis) in individuals with epilepsy. The primary goals of this study encompass the following objectives: 1) identifying neuroanatomical and molecular mechanisms by which the ventromedial nucleus of the hypothalamus (VMH) is involved in epileptogenic processes and 2) determining the genomic landscape of the epileptogenic processes in the VMH using spatial transcriptomics. By elucidating mechanisms and signaling pathways regulating the reorganizational processes in the VMH that lead to brainstem-tonic seizures and increased risk for Sudden Unexpected Death in EPilepsy (SUDEP), potential druggable targets for epilepsy and/or SUDEP can be identified.

PI_NAMEs: FERLAND, RUSSELL JAMES (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Age;Anatomy;Animal Model;Area;Behavior;Behavioral;Brain;brain abnormalities;Brain Stem;Cardiovascular system;Cell Nucleus;cell type;Cessation of life;Clinical Research;Clonic Seizure;Complex;Convulsants;Critical Pathways;Data;digital;druggable target;Epilepsy;Epileptogenesis;Event;experience;Exposure to;Fiber;Flurothyl;Gatekeeping;Gene Deletion;Gene Expression;Gene Proteins;Generalized Epilepsy;Generalized seizures;Genes;Genetic;Genetic Transcription;Genomics;Glutamate Transporter;Glutamates;Goals;Hippocampus;Human;human model;Hypothalamic structure;Incubated;Individual;Inhalation Exposure;insight;Lesion;Mediating;Modeling;Molecular;Mus;nano-string;Neuroanatomy;Neurons;novel;novel strategies;Outcome;overexpression;Pathogenesis;Pathway Analysis;Pathway interactions;Phase;Population;Pre-Clinical Model;presynaptic;prevent;preventable epilepsy;Prevention strategy;Probability;Process;Prosencephalon;protein expression;Quantitative Reverse Transcriptase PCR;Research;respiratory;response;Rest;Risk;Role;Seizures;Signal Pathway;Signal Transduction;Stains;sudden unexpected death in epilepsy;symptom management;Synaptic Vesicles;System;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapy development;Time;Tonic Seizures;transcriptome;transcriptomics;treatment strategy;Work

PROJECT_TITLE: The Role of the Ventromedial Nucleus of the Hypothalamus in Epileptogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-W (SU)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: The field of FLASH radiotherapy has experienced wide interest and growth and could be a critical area of development for better normal tissue sparing in radiotherapy. The Overall Objective of this application is to use protoacoustic/ultrasound imaging to precisely guide FLASH proton therapy which will greatly facilitate the investigation, translation, and adoption of FLASH therapy to benefit cancer patients by reducing the toxicities of radiation therapy on cancer patient.

PI_NAMEs: CHEN, YONG ;REN, LEI ;XIANG, LIANGZHONG SHAWN (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;Acceleration;acoustic imaging;Acoustics;Address;Adoption;Adult;Affect;Anatomy;Animal Model;Area;Cancer Patient;Cause of Death;Clinical;clinical application;Collaborations;Computer Simulation;Data;data acquisition;Deposition;design;detector;Development;Dose;dose information;Dose Rate;dosimetry;Effectiveness;Engineering;Ensure;experience;experimental study;Film;Goals;Grant;Growth;high risk;Human;Image;Image Enhancement;image reconstruction;imaging capabilities;imaging modality;imaging system;Imaging Techniques;in vivo;in vivo imaging system;in vivo Model;indexing;Industrialization;Industry;industry partner;innovation;Institution;interest;Investigation;Ions;Malignant Neoplasms;Measurement;mechanical properties;Methods;Modality;multidisciplinary;Normal tissue morphology;novel;Organ;Outcome;Patients;Performance;phantom model;physical property;Physiologic pulse;Positioning Attribute;proton beam;proton therapy;Protons;prototype;Public Health;Publications;Radiation;Radiation therapy;Radiation Toxicity;Radiology Specialty;Radiometry;real-time images;Research;Resolution;Signal Transduction;simulation;stem;success;System;Techniques;Technology;temporal measurement;Testing;Tissues;Toxic effect;Transducers;Translations;Treatment-related toxicity;tumor;Ultrasonography;ultrasound;Uncertainty;Validation;Work

PROJECT_TITLE: 3D In vivo dosimetry for FLASH proton therapy

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Gaps in neurologic health and access to healthcare for neurologic disorders, further amplified by the COVID-19 pandemic, are widening in the US and worldwide. To translate knowledge about health disparities into evidence-based interventions that improve neurologic outcomes for the most underserved and vulnerable populations, clinician researchers and PhD scientists need rigorous training and mentoring in health equity research methods, which are largely lacking from neurology research training programs. The proposed ENgaging Leaders In Global and local HealTh Equity in Neurology (ENLIGHTEN) fellowship was developed in direct response to the need for a cohesive interdisciplinary training program in neurologic health equity research methods for global and local settings.

PI_NAMEs: CHOW, FELICIA C.;OVBIAGELE, BRUCE  (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: health equity;Neurology

PROJECT_TITLE: ENLIGHTEN (ENgaging Leaders In Global and local HealTh Equity in Neurology)


ORG_CITY: WEST HARTFORD

ORG_NAME: UNIVERSITY OF HARTFORD

ORG_STATE: CT

PHR: PROJECT NARRATIVE The goal of the proposed U-RISE program at the University of Hartford is to develop diverse students who will become leaders in biomedical research fields. We will accomplish these goals via two specific aims, 1) To increase the number of undergraduate UHart students from underrepresented backgrounds who are interested in pursuing careers in biomedical research, and 2) To develop the research, critical thinking, and science communication skills of U-RISE trainees. The goal of the U-RISE training Program is aligned with UHart’s priorities making us an ideal institution to support undergraduate students from underrepresented backgrounds as they begin their training in biomedical research.

PI_NAMEs: LEVESQUE, AIME A;THOMAS-CHARLES, CINDY  (contact)

PROJECT_TERMS: Biomedical Research;career;Classification;Communication;Communities;Critical Thinking;diversity and inclusion;Doctor of Philosophy;Educational Curriculum;Educational workshop;Enrollment;Extramural Activities;Faculty;Funding;Goals;graduate school preparation;high standard;Institution;interest;Interview;Intramural Research;Investments;Journals;Learning;matriculation;outreach;programs;prospective;recruit;Research;Research Training;Science;skills;social;Students;success;Techniques;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities

PROJECT_TITLE: The University of Hartford U-RISE Program


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Nutrition;Obesity

PHR: PROJECT NARRATIVE Advances in understanding of energy balance regulation and mechanisms underlying obesity pathogenesis requires approaches that enable effective and accurate measures of energy expenditure, energy intake, substrate oxidation and physical activity. For more than two decades, the University of Washington Nutrition Obesity Research Center (NORC) Energy Balance Core has provided investigators with access to state-of-the- art rodent metabolic phenotyping services for studies related to nutrition, obesity and metabolism using a metabolic cage system that has not kept up with technological advances, and is no longer repairable, should a system failure occur. In this application, we request funding to purchase a new Sable Systems Promethion Core system, which will dramatically improve throughput of services provided to our investigators; provide several new and exciting capabilities, including the ability to interface with sophisticated neuroscience technologies, use of stable isotopes to measure substrate oxidation, and computer-controlled food access; and ensure that existing commitments to our research community are honored while offering state-of-the art support to the greater UW scientific community.

PI_NAMEs: MORTON, GREGORY J (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Address;Applications Grants;base;Communities;Computers;Defect;design;Disease;energy balance;Energy Intake;Energy Metabolism;Ensure;Equipment;Exhalation;feeding;Fiber;Food Access;Funding;gas analyzer;Health Care Costs;Homeostasis;improved;Indirect Calorimetry;Infrastructure;insight;instrument;International;Label;Letters;Maintenance;Martes zibellina;Measurement;Metabolic;Metabolic Diseases;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Neurons;Neurosciences;novel;nutrition;Obesity;optogenetics;oxidation;Pathogenesis;Photometry;Physical activity;Population;Productivity;repaired;Research;Research Personnel;Research Support;Rodent Model;S10 grant;Science;Services;Source;stable isotope;System;Techniques;Time;Time-restricted feeding;United States National Institutes of Health;Universities;Wait Time;Washington

PROJECT_TITLE: Sable Systems Promethion Core system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-M (30)]


ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

PHR: Most common human diseases are difficult to study because they are genetically complex. Conducting human genetic studies that include enough subjects with sufficiently detailed data to make definitive conclusions remains challenging, despite significant advances in genome technologies (e.g. DNA sequencing and editing). Most of these obstacles can be overcome by using standardized, genetically diverse laboratory mice, which offer known and reproducible genetic and phenotypic variation. The goal of the Special Mouse Strain Resource at The Jackson Laboratory is to: i) maintain and distribute these unique mouse populations to the biomedical research community, ii) further develop advanced resources for systems genetics and, iii) to provide leadership in best practices for research and reproducibility.

PI_NAMEs: REINHOLDT, LAURA G (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Address;Animals;Archives;biobank;Biological;Biomedical Research;Breeding;Caring;Cells;Certification;Collaborations;Collection;Communities;Complex;Consomic Strain;cost;Data;Derivation procedure;design;Development;Disease;Dissection;DNA sequencing;embryo cryopreservation;Ensure;Environmental Risk Factor;Epigenetic Process;Faculty;Foundations;Funding;Future;gene environment interaction;Genes;Genetic;Genetic Drift;Genetic Engineering;Genetic Epistasis;Genetic Heterogeneity;genetic manipulation;Genetic Research;genetic resource;Genetic study;Genetic Variation;Genome;Genotype;Geography;Goals;Health;Health Status;Heritability;Human;Human Biology;human disease;Human Genetics;Inbred Strain;Inbreeding;Infrastructure;Institution;Investments;Laboratories;Laboratory mice;Leadership;Legal;Maps;Medical Records;member;model design;Modeling;Mouse Strains;Mus;outreach;personalized medicine;Phenotype;Physiological;Play;Population;preservation;Production;Qualifying;Quantitative Trait Loci;Quarantine;Recombinants;repository;Reproducibility;Request for Proposals;Research;Research Personnel;Resources;Role;Sample Size;Source;sperm cell;Standardization;System;Technology;The Jackson Laboratory;Tissues;tool;trait;United States National Institutes of Health;Variant;Vendor;Work

PROJECT_TITLE: Special Mouse Strains Resource

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-J (55)]


NIH_SPENDING_CATS: Genetics;Human Genome

PROJECT_TERMS: Affect;Amino Acid Sequence;base;Bioinformatics;bioinformatics pipeline;Biological;Biomedical Research;Catalogs;Collaborations;Communities;comparative;Complex;computerized tools;computing resources;Data;data curation;data integration;data management;data resource;Data Science;Data Set;Databases;Development;Disease;disease model;empowerment;Gene Frequency;Genetic;genetic analysis;genetic approach;Genetic Research;genetic resource;genetic strain;genetic variant;Genetic Variation;Genome;genome resource;genomic data;Genomics;Genotype;Geography;Goals;Graph;Human;human reference genome;improved;in silico;Inbreeding;Informatics;Infrastructure;Institution;Internet;Laboratories;Laboratory mice;Link;Maps;Modeling;mouse genetics;Mouse Strains;Mus;Nature;Nucleotides;operation;pan-genome;Phenotype;phenotypic data;Policies;Population;Population Genetics;programs;Publishing;Quality Control;Quantitative Trait Loci;reference genome;Reporting;Research;Research Design;Research Infrastructure;Research Personnel;Research Support;Resource Development;Resources;Services;statistics;Strategic Planning;System;Technology;The Jackson Laboratory;Training;training opportunity;trait;transcriptome;United States National Institutes of Health;Update;Variant;variant detection

PROJECT_TITLE: Harnessing the power of pangenomics to strengthen SMSR operations and resources


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: KINGSVILLE

ORG_NAME: TEXAS A&M UNIVERSITY-KINGSVILLE

ORG_STATE: TX

PHR: Narrative Neurodegenerative diseases are one of the leading causes of mortality in the United States, many of which are not well understood or treatable. This research will explore the underlying mechanisms of a recently identified mutant gene called TBK1 in amyotrophic lateral sclerosis (ALS), a rapidly progressive neurodegenerative disease mainly attacking motor neurons, by investigating the impact on the nervous system when wild-type and mutant human TBK1 genes are expressed in fruit flies or when TBK1 orthologue IK2 gene function is perturbed. In the end, this research will provide a better understanding of ALS with the hope of developing effective therapeutic treatments.

PI_NAMEs: HE, FANG  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Address;Affect;ALS patients;Amyotrophic Lateral Sclerosis;Animal Model;Autophagocytosis;Behavioral;Binding;Caspase;Complex;Critical Pathways;Cultured Cells;Cyclic AMP-Dependent Protein Kinases;Dendrites;Disease;Drosophila genus;Drosophila melanogaster;effective therapy;exome sequencing;experimental study;Failure;familial amyotrophic lateral sclerosis;fly;Future;Gene Expression;gene function;Genes;Genetic;genetic analysis;Genetic Predisposition to Disease;Human;human disease;human model;I-kappa B Proteins;IkappaB kinase;Impairment;Inflammation;Inflammatory Response;insight;Investigation;Locomotion;Mediating;Modeling;Molecular;Molecular Analysis;mortality;Motor Neurons;mutant;Mutate;Mutation;Nature;Nerve Degeneration;Nervous System;Nervous System Physiology;neural;Neurodegenerative Disorders;neuroinflammation;Neurons;NF-kappa B;novel;overexpression;Pathogenesis;Pathway interactions;Phenotype;Phosphorylation;Play;Process;protein aggregation;Proteins;Quality Control;Reporting;Research;RNA;Role;sporadic amyotrophic lateral sclerosis;Symptoms;TANK-binding kinase 1;therapeutically effective;tool;translational potential;United States;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Behavioral and Molecular Alterations in Drosophila with Modulated IK2/TBK1 Gene Expressions


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

ORG_CITY: NEW YORK

ORG_NAME: MEDGAR EVERS COLLEGE

PHR: U-RISE at Medgar Evers College  PROJECT NARRATIVE The U-RISE at Medgar Evers College program prepares students underrepresented in biomedical sciences for research-intensive graduate programs through experiential classroom learning and interdisciplinary research experiences. Diversity in STEM research, higher education, and the workforce will drive the biomedical sciences forward, help to stimulate economic growth, and help create a more global and inclusive STEM community properly situated to address the needs of underrepresented populations, especially in chronic disease and health-related research. Inter-institutional opportunities are essential for providing future scientists with interdisciplinary training to address multifaceted health problems from a comprehensive perspective.

PI_NAMEs: MUJTABA, SYED SHIRAZ;NUR-E-KAMAL, ALAM ;PATWARY, MOHSIN U. (contact)

PROJECT_TERMS: Acceleration;African American;Ally;apprenticeship;Award;Awareness;Biological Sciences;Biology;Biomedical Research;Black American;career;Cities;Collaborations;college;computer science;Credentialing;diversity and inclusion;Doctor of Medicine;Doctor of Philosophy;Education;Educational workshop;Employment;Ensure;Environmental Science;Equity;experience;Face;First Independent Research Support and Transition Awards;Gravitation;Health;higher education;Institution;Institutionalization;Intellectual Interest;interest;Mathematics;matriculation;National Institute of General Medical Sciences;New York;New York City;programs;recruit;Research;Research Training;Schools;Science;STEM field;STEM research;Students;success;Training;trend;undergraduate research;undergraduate student;Universities;university student

PROJECT_TITLE: Medgar Evers College Undergraduate Research Training Initiative for Student Enhancement (U-RISE)


ADMINISTERING_IC: DD

IC_NAME: NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: This study will shed light on a wide variety of genetic, prenatal, early-life and family factors that influence the risk for autism spectrum disorder (ASD) and on differences and similarities in the behaviors, abilities, and health of preschoolers with ASD. It will also provide insights into the experiences of adolescents with ASD as they mature. By helping to explain the causes of ASD and how ASD affects children, youth and young adults, this project will contribute to efforts to reduce the risk of ASD and improve the outcomes of affected children.

PI_NAMEs: LADD-ACOSTA, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: OGUNFUYI, SHAKIRATU BIOLA

PROJECT_TITLE: Study to Explore Early Development (SEED) Follow up Studies, Components A, B, D & E


ADMINISTERING_IC: OH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND STATE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative We are seeking renewal funding for our graduate training program at Portland State University (PSU) in an under-represented, but growing discipline of Occupational Safety and Health, namely, Occupational Health Psychology (OHP). OHP is an interdisciplinary field that involves the application of psychological principles for improving the quality of work-life and for promoting the safety, health, and well-being of people at work. OHP researchers and practitioners draw from the domains of public health, preventive medicine, nursing, industrial engineering, law, epidemiology, and psychology to develop sound theory and practice for protecting and promoting safety, health, and well-being in the workplace. We are seeking to innovate this training by expanding to include Total Worker Health®.

PI_NAMEs: YANG, LIUQIN  (contact)

PROJECT_TITLE: Graduate Training in Occupational Health Psychology and Total Worker Health


ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Appalachian Training Program in Occupational Health and Safety Project Narrative Appalachia is arguably one of the most underserved regions in the country, with an unacceptably high burden of occupational disease and injuries. The Occupational Medicine, Industrial Hygiene, and Occupational Safety and Health Engineering programs produce skilled professionals who understand the workplaces of this rural area, diagnose and treat injured workers, focus upon use of engineering to measure and identify hazards, understand failure modes and effects to engineer out such hazards and who are prepared for and dedicated to the public health aspects of mitigation and prevention in the region. This is the only NIOSH- supported Training Project Grant in Occupational Medicine and one of two in Occupational Safety and Industrial Hygiene located in the entire Appalachian region, comprising portions of 14 states.

PI_NAMEs: MARTIN, CHRISTOPHER JOHN (contact)


ORG_CITY: PITTSBURGH

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The National Mesothelioma Virtual Bank (NMVB) collects tumor tissue, blood samples and other protein, genomic and imaging data from consented patients with mesothelioma. Biospecimens from patients with documented occupational exposure to asbestos as well as de-identified clinical and research data are then made available for research studies. Investigators can search the study database to identify and request specific cohorts via the NMVB website which is the largest and most accessible resource for this rare and fatal disease.

PI_NAMEs: BECICH, MICHAEL JOHN (contact);DACIC, SANJA

PROJECT_TITLE: Continuation and Expansion of the National Mesothelioma Virtual Bank for Translational Research (U24) - 2021


ORG_CITY: Columbus

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: The acid sensing ion channels (ASICs) induce neuronal death during persistent cerebral acidosis and contribute to brain damage following ischemia. This proposal will test novel methods to inhibit ASIC dependent cell death without impacting ASIC’s physiological function. The proposed work will have broad implications for the prevention of injury following ischemic stroke and other disorders accompanied by cerebral acidosis.

PI_NAMEs: ASKWITH, CANDICE C (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acidosis;Acids;Agonist;ASIC channel;Biochemical;Biological Assay;Blood flow;Brain;Brain Injuries;Brain Ischemia;Cell Death;Cell Death Induction;Cell Line;Cerebrum;Cessation of life;Clinical;Co-Immunoprecipitations;Collaborations;Data;delta opioid receptor;Disease;extracellular;Hour;In Vitro;in vivo;Individual;Induced Neurons;injury prevention;Intervention;Investigation;Ion Channel;Ions;Ischemia;Ischemic Brain Injury;ischemic injury;Ischemic Stroke;Knockout Mice;Label;Measurement;Measures;Mediating;Methods;Middle Cerebral Artery Occlusion;Modeling;Modification;Molecular Profiling;Multiple Sclerosis;Mus;Mutation;Nervous System Trauma;Neurodegenerative Disorders;neuron loss;Neurons;neuroprotection;new therapeutic target;novel;Opioid agonist;Outcome;Pathologic;pharmacologic;Phosphorylation;Phosphorylation Site;Physiological;Physiology;Play;Preparation;prevent;Prevention;protein protein interaction;Proteins;Receptor Activation;Research Personnel;Retinal Degeneration;Role;Signal Pathway;Signal Transduction;Slice;Spinocerebellar Ataxias;Testing;Tissues;Toxic effect;Traumatic Brain Injury;Work

PROJECT_TITLE: Investigations into ASIC1a-dependent neuronal death

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Infectious Diseases;Natural Products

ORG_DEPT: CHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative  Experiments to devise new methods to synthesize cyclic peroxides will enable new approaches to prepare this family of potential drugs and explore how they are active as anti-cancer agents. Studies of the reactions involved in organic synthesis and carbohydrate chemistry will help medicinal chemists use such reactions to make biologically active compounds with greater control of three-dimensional structure. These studies are relevant to human health because they could lead to new ways of making medicines.

PI_NAMEs: WOERPEL, KEITH ALLEN (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acetals;Address;Antineoplastic Agents;Apoptosis;Attention;Bacterial Infections;Biochemical Reaction;Biological;Biological Models;Biological Process;Carbohydrate Chemistry;Carbohydrates;Cell Death;cell killing;chemical reaction;Chemicals;Collaborations;design;Disease;Enzyme Inhibitor Drugs;Exhibits;experimental study;Family;Funding;Goals;Health;Human;innovation;Investigation;Ions;Literature;Malaria;Malignant Neoplasms;Medicine;Metabolic;Methods;Natural Products;novel strategies;Organic Synthesis;Pathway interactions;Periodicity;Peroxides;Pharmaceutical Preparations;professor;Property;Reaction;Research;Sialic Acids;Study models;sugar;Synthesis Chemistry;three dimensional structure;Universities;Virus Diseases

PROJECT_TITLE: New Methods for the Synthesis of Biologically Active Compounds


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Natural Products;Neurodegenerative;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: DAVIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Compounds capable of promoting neuroplasticity, such as ketamine and serotonergic psychedelics, have enormous potential for treating neuropsychiatric and neurodegenerative diseases characterized by cortical atrophy, but their hallucinogenic effects limit their clinical scalability. Recently, our group discovered that it is possible to engineer non-hallucinogenic analogs of psychedelics capable of promoting neuroplasticity after a single administration and producing sustained therapeutic effects across disease indications. The research described here seeks to establish new synthetic strategies for accessing plasticity-promoting compounds as well as methods for evaluating their efficacy, safety, and mechanisms of action—information that will ultimately lead to the development of new treatments for diseases such as depression, posttraumatic stress disorder, substance use disorder, Alzheimer’s disease, and Parkinson’s disease, among others.

PI_NAMEs: OLSON, DAVID E (contact)

PROJECT_TERMS: Alzheimer's Disease;analog;Anhedonia;Animal Model;Anxiety;Atrophic;Autopsy;Biological Assay;Brain Diseases;Cellular Assay;cerebral atrophy;Chemicals;Clinical;Dendritic Spines;density;Development;Disease;Engineering;Functional disorder;G-Protein-Coupled Receptors;Goals;Hallucinations;Hallucinogens;human imaging;Impaired cognition;Impulsivity;in vivo;Ketamine;Knowledge;Lead;Mental Depression;Methods;Molecular;Motivation;Natural Products;Neurodegenerative Disorders;Neuronal Plasticity;Neurons;neuropsychiatric disorder;Parkinson Disease;Pharmaceutical Chemistry;Play;Post-Traumatic Stress Disorders;Prefrontal Cortex;Property;rational design;Research;Safety;scaffold;small molecule;Structure;Structure-Activity Relationship;Substance Use Disorder;Synapses;Therapeutic;Therapeutic Effect;tool;Work

PROJECT_TITLE: Chemical and Molecular Tools for Modulating GPCR Function


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: The epidermal growth factor receptor (EGFR) plays important roles in mammalian development, wound healing, tissue regeneration and homeostasis, and is involved in various pathologies, most notably, carcinogenesis and metastatic processes. The mechanisms regulating EGFR signaling are incompletely understood. The proposed research will address the fundamental questions of whether specific signaling pathways can be activated by EGFR inside the cells from endosomes and examines the mechanisms regulating this endosomal signaling.

PI_NAMEs: SORKIN, ALEXANDER D (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Actins;Address;Adult;Biological Assay;carcinogenesis;Cells;Cellular Assay;Chimeric Proteins;Clathrin;Complex;Development;Endocytosis;Endosomes;Enzymes;Epidermal Growth Factor Receptor;Eukaryota;experimental study;Family;Fluorescence;Funding;Gene Fusion;Generations;Genes;Homeostasis;Human Pathology;in vivo;Label;Ligands;Mass Spectrum Analysis;Measures;Mediating;metastatic process;Methods;Modeling;Molecular;Monitor;National Institute of General Medical Sciences;novel;novel strategies;p38 Mitogen Activated Protein Kinase;Pathology;Pathway interactions;phosphoproteomics;Play;Positioning Attribute;Process;Proteins;Proteome;ratiometric;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Regulation;Research;Role;screening;Signal Pathway;Signal Transduction;Sorting;spatiotemporal;Stress;temporal measurement;tissue regeneration;trafficking;VAV2 gene;Vesicle;wound healing

PROJECT_TITLE: EGF Receptor Endocytosis: Mechanisms and Role in Signaling

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cellular growth, development, movement and communication absolutely require accurate intracellular cargo transport by vesicle targeting and membrane fusion. Essential components of these fundamental cell biological processes are the exocyst complex, Sec1, SNARE proteins, and their regulatory partners. These mechanisms are conserved from yeast to man, and have been implicated in a variety of human diseases, such as cancer, diabetes, ciliopathies, and infections by pathogens. Our multidisciplinary studies will lead to a molecular understanding of the regulation of vesicle tethering and membrane fusion. In addition, our research will also lead to the development of many technologies, constructs, reagents and ideas that will be valuable tools for studying how these factors regulate secretion in all eukaryotic cells.

PI_NAMEs: MUNSON, MARY  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Architecture;Binding;Biochemical;Biological;Biological Process;biophysical techniques;cell growth;Cell membrane;Cells;Cellular Morphology;ciliopathy;Communication;Complex;Development;Diabetes Mellitus;Disease;Eukaryotic Cell;Functional disorder;Genetic;Growth;Hormones;Human;human disease;Infection;Knowledge;Lipids;Malignant Neoplasms;man;Membrane;Membrane Fusion;Methods;model organism;Molecular;Movement;multidisciplinary;Neurons;neurotransmission;Organelles;Organism;pathogen;Process;Proteins;Quality Control;rab GTP-Binding Proteins;Reagent;Regulation;Research;rho GTP-Binding Proteins;Role;Saccharomyces cerevisiae;SNAP receptor;Specificity;Techniques;Technology;tool;Vesicle;vesicle transport;Yeasts

PROJECT_TITLE: Dissecting the Molecular Mechanisms of Exocytic Vesicle Tethering and Fusion


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Over-nutrition and obesity are important contributors to the cardiovascular disease epidemic in the United States and worldwide. A major reason for the increase in cardiovascular disease is the rapidly increasing prevalence of obesity in both adults and children, many of whom will develop cardiovascular disease, and so the burden on our society is tremendous. The Nutrition, Obesity and Atherosclerosis Training Program trains new generations of postdoctoral MD clinician-scientists and PhD scientists to tackle these problems, taking advantage of the multidisciplinary and broad training environment at the University of Washington.

PI_NAMEs: BORNFELDT, KARIN E. (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE / LAY SUMMARY This project explores how the cholangiocyte epigenome and downstream signaling pathways influence the progression of Primary Sclerosing Cholangitis, a serious liver disease with no effective therapy except liver transplant. We explore the molecular mechanisms that determine if cholangiocytes arrest in the cell cycle (become senescent) or proliferate (resist senescence), and how these two cholangiocyte populations influence the development of fibrosis. If successful, the results could lead to new and effective treatments.

PI_NAMEs: LARUSSO, NICHOLAS F. (contact);O'HARA, STEVEN P

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Address;Affect;American;Animal Model;Apoptosis;ATAC-seq;bile duct;Biliary;Biological;biological adaptation to stress;Biological Assay;c-myc Genes;c-myc Proto-Oncogenes;Cell Communication;Cell Cycle;Cell Cycle Arrest;Cell Line;Cell Separation;Cells;ChIP-seq;cholangiocyte;Chromatin;Chromatin Remodeling Factor;Colon;Communication;cost;Data;Development;Disease;Disease Progression;Duct (organ) structure;effective therapy;Enhancers;EP300 gene;Epigenetic Process;epigenome;ETS1 gene;Exhibits;experimental study;Fibroblasts;fibrogenesis;Fibrosis;Functional disorder;Gene Expression;Gene Modified;Genetic;Genetic Transcription;genome-wide;glycogen synthase kinase 3 beta;Hepatic;Hepatic Stellate Cell;high throughput analysis;Histologic;Histone Acetylation;histone acetyltransferase;Human;human model;human tissue;In Vitro;in vivo;Inflammatory Bowel Diseases;Injury;intercellular communication;Life;Liver;Liver diseases;liver transplantation;Malignant neoplasm of gallbladder;Mediating;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;Mus;Myofibroblast;new therapeutic target;novel;novel therapeutics;Organoids;Outcome;Pathogenesis;Pathologic;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Phosphotransferases;Population;primary sclerosing cholangitis;Proliferating;promoter;Proto-Oncogene Proteins c-akt;Reporting;Research;Resistance;response;response to injury;Risk;Rodent;senescence;senescent cell;Signal Pathway;Signal Transduction;Stress;Techniques;Testing;therapeutic target;Tissues;transcription factor;Transcription Factor AP-1;transcriptome sequencing;Work

PROJECT_TITLE: Pathophysiology of Biliary Disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Hematology;Nanotechnology;Physical Injury - Accidents and Adverse Effects

ORG_CITY: CLEVELAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: The overall goal of the proposed research is to elucidate the multi-step mechanisms by which platelets form hemostatic clots, and mimic and integrate these mechanisms on lipid-peptide based nanoparticle systems to create `artificial platelet' constructs that can be used for transfusion treatment of bleeding complications. Platelet transfusion can significantly save lives in heavy bleeding scenarios (e.g. trauma) but platelets are unavailable in limited resource hospitals and in civilian and military roadside/emergency medicine framework; this is where proposed `artificial platelets' can provide a unique technology solution to rapidly stanch bleeding and save lives.

PI_NAMEs: SEN GUPTA, ANIRBAN  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acute;Address;Adhesions;Alpha Granule;Alteplase;analog;Attenuated;Award;Binding;Biocompatible Materials;Blood;Blood Coagulation Factor;Blood Platelets;Clinical;Coagulation Process;Collagen;design;Emergency Medicine;Encapsulated;Engineering;Enzymes;Exposure to;Fibrin;Fibrinogen;functional mimics;Generations;Goals;Hemorrhage;Hemostatic Agents;Hemostatic function;high risk;Hospitals;Hybrids;improved;In Vitro;in vivo;Injury;innovation;Integrins;Kinetics;Legal patent;Life;Lipids;Liposomes;Mediating;Military Personnel;military trauma;mimetics;mimicry;Modeling;Morphology;mortality;Mus;N-formylmethionylphenylalanine;nano;nanoparticle;Patients;Peptides;peptidomimetics;Phosphatidylserines;Phospholipids;Plasma;Plasmin;Platelet Transfusion;Play;Polyphosphates;portability;Research;Resources;response;Rodent;Role;self assembly;Site;Stimulus;Surface;System;Tail;Technology;Testing;Thrombin;Transfusion;Trauma;trauma centers;Traumatic Hemorrhage;Vascular Endothelium;von Willebrand Factor;Whole Blood

PROJECT_TITLE: Heteromutivalent Peptide-Lipid Nanoconstructs as Artificial Platelet Analogues

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Clinical Research;Dental, Oral, and Craniofacial Disease;Diabetes;Digestive Diseases;Infectious Diseases;Microbiome

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative The relationship between periodontitis and type II diabetes (T2D), co-occurring diseases that are among the most prevalent chronic illnesses in the US, is characterized by the former’s ability to increase the risk of severe diabetic complications, including death, in patients with both diseases. This project aims to understand the effect of periodontitis, and its associated mouth microbiome dysbiosis, on metabolic dysfunction in T2D. This project has an immediate impact on the understanding of periodontitis pathophysiology in systemic metabolic dysfunction.

PI_NAMEs: JUNE, ARMOND  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Activities of Daily Living;Adult;Affect;Aftercare;Animals;Bacteroides;Branched-Chain Amino Acids;Cardiovascular Diseases;Cessation of life;Chronic;Chronic Disease;Clinical;Cohort Analysis;Colorectal Cancer;Communicable Diseases;Complications of Diabetes Mellitus;Dental Schools;Development;diabetes control;Diabetes Mellitus;diabetes pathogenesis;diabetic;Disease;dysbiosis;Endocrinology;Endotoxemia;experience;experimental study;Feces;Feedback;Fellowship;Firmicutes;Functional disorder;Genes;Genetic Variation;glycemic control;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;gut inflammation;gut microbiome;Health;Hemoglobin concentration result;high risk;Human;human old age (65+);Immune response;immunogenicity;improved;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Insulin Resistance;intestinal barrier;Knowledge;Laboratories;Link;Longitudinal cohort;Mediating;Medicine;Mentorship;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;metabolic phenotype;metabolic profile;metagenomic sequencing;Methodology;Microbe;microbial;microbiome;microbiome composition;microbiome research;microbiome sequencing;microbiome signature;modifiable risk;Molecular;Mouth Diseases;National Research Service Awards;Neuropathy;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;Oral;Oral Characters;oral microbiome;Outcome;Oxidative Stress;pathobiont;pathogen;Pathogenicity;Pathologic;Pathway interactions;Patients;Pattern;Periodontitis;Permeability;Physicians;Population;Preceptorship;Research;Resolution;Rheumatoid Arthritis;Risk;Risk Factors;Role;Sampling;Scientist;Severities;Shotguns;Signal Transduction;sugar;systemic inflammatory response;Testing;Training;transmission process;United States;Universities;Volatile Fatty Acids;Work

PROJECT_TITLE: Oral to Gut Microbiome Transmission in Periodontitis and Type 2 Diabetes


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: Technological advancements in stem cells, gene therapy, and retinal prostheses show great promise for restoring or providing new light sensitivity to retinas of the blind; however, understanding of the basic circuitry for daylight vision lags behind the technology to provide light sensitivity. There is an urgent need to elucidate the circuitry of visual pathways and to understand their role in visual perception in order to identify the best therapeutic strategies and the most effective implementations of them.

PI_NAMEs: NEITZ, JAY  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: 3-Dimensional;Agreement;Area;Behavior;Biological;blind;Brain;cell type;Cells;Characteristics;circadian;Code;Color;Color Visions;Computer software;Cone;connectome;Conscious;Data;detector;Development;Electron Microscopy;Electrophysiology (science);Elements;Equilibrium;Esthesia;experience;Eye Movements;Face;ganglion cell;Hand;Human;Image;Individual;Inner Plexiform Layer;Investigation;Knowledge;Light;light microscopy;Link;Macaca;Mediating;Motor;Movement;Neurons;object recognition;Outcome;outer plexiform layer;Output;Pathway interactions;Perception;Photophobia;Play;preservation;Primates;Property;Protocols documentation;Publishing;reconstruction;Resolution;response;Retina;Retinal Ganglion Cells;retinal imaging;retinal neuron;retinal prosthesis;Role;Sample Size;Scanning Electron Microscopy;Shapes;sight for the blind;sight restoration;Signal Transduction;stem cell gene therapy;Sum;Surface;Synapses;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;tissue preparation;Tissues;Vision;Visual;Visual Pathways;Visual Perception;Work

PROJECT_TITLE: Linking retinal circuits to perception

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Nanotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Project Narrative This project will apply what we have learned about the way in which carbon-based nanomaterials behave chemically in order to restore function to tissue damaged by free radicals and, to develop a new therapy for severe traumatic brain injury by modifying a starting material that is already used in patients, activated charcoal. If successful, starting with this material may speed the possibility of developing a treatment that can be used in humans. Because the kinds of damage that traumatic brain injury causes is also seen in other disorders such as those associated with aging, there is a broad potential for this therapeutic approach in some of our most serious debilitating conditions.

PI_NAMEs: HEGDE, MURALIDHAR L;KENT, THOMAS  (contact);TOUR, JAMES MITCHELL;ZHAO, JING

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Activated Charcoal;Acute;Acute Brain Injuries;Address;Aging;Antioxidants;Binding Sites;Blood - brain barrier anatomy;Brain Injuries;Carbon;Carbon nanoparticle;carboxylate;Cell Aging;Cells;Characteristics;Chelating Agents;Chemicals;Chronic Disease;Clinic;Coal;Complex;Contusions;covalent bond;Deferoxamine;design;disability;Disease;DNA Damage;DNA Double Strand Break;Electron Transport;Environment;Enzymes;Ethylenes;Event;Free Radicals;functional decline;functional outcomes;functional restoration;Funding;Generations;Genomics;Glycols;Goals;Good Manufacturing Process;graphene;Hemin;Hemoglobin;Hemorrhage;Human;hydrophilicity;Impaired cognition;improved;In Vitro;in vivo;in vivo Model;Inflammation;Injury;Iron;Iron Chelation;lead candidate;Learning;Lesion;Link;Materials Testing;Mediator;mild traumatic brain injury;mimetics;Mitochondria;mitochondrial dysfunction;Modeling;nanomaterials;nanoparticle;Nature;Nervous System Physiology;Neurons;new therapeutic target;novel;novel therapeutics;Nuclear Accidents;Outcome;Oxidation-Reduction;oxidative damage;Oxidative Phosphorylation;particle;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;prevent;Quantum Dots;Quinones;Resistance;response;Rodent;Role;senescence;Site;Source;Speed;Superoxide Dismutase;Testing;Therapeutic;Therapeutic Uses;Tissues;Toxic effect;Traumatic Brain Injury;Work

PROJECT_TITLE: Novel Carbon Nanozyme Mechanisms for Traumatic Brain Injury

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Microbiome;Nutrition;Obesity

ORG_CITY: PROVIDENCE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: The proposed research is highly relevant to public health because defining how antibiotic-mediated microbiome disruption contributes to complications such as obesity and diabetes may, in the long run, identify ways to alleviate these conditions for millions of Americans. This work will define the impacts of antibiotics on the metabolic environment of the murine gut, host metabolite availability and weight gain. In addition to generating fundamental scientific discoveries, this research will also fulfill NIH goals by generating a mechanistic perspective on how antibiotics contribute to diabetes, digestive diseases, nutritional disorders, and obesity.

PI_NAMEs: BELENKY, PETER  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Adult;American;Amoxicillin;Animals;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Bacteroidetes;beta-Lactams;Blood Glucose;Butyrates;Cellular Metabolic Process;Child;Clinical;clinically relevant;combat;Communities;cost;Data;Diabetes Mellitus;Diet;dietary;Dietary Component;Digestive System Disorders;Dose;Environment;Farm;Fermentation;fighting;Firmicutes;Genetic Transcription;Glucose;Goals;gut bacteria;gut microbiome;Health;health determinants;Human;Hyperglycemia;Inflammation;Inflammatory Response;insight;Insulin Resistance;Intervention;Laboratory mice;Lead;Link;Livestock;Malnutrition;Mediating;Metabolic;Metabolic dysfunction;Metabolism;metabolome;Methodology;microbial community;microbial composition;microbiome;microbiome alteration;microbiome composition;microbiota;Morbidity - disease rate;Motivation;multiple omics;Mus;Nutrient;nutrient absorption;Nutrition Disorders;Obesity;Outcome;pathobiont;pathogen;Penicillins;Pharmaceutical Preparations;Physiology;Probiotics;Public Health;Publishing;Research;response;restoration;Signaling Molecule;systemic inflammatory response;Taxonomy;Testing;theories;Toxic effect;United States National Institutes of Health;Vitamins;Weight;Weight Gain;Work;Xenobiotics

PROJECT_TITLE: Relating impacts of antibiotics on the gut metabolome and microbiome to host physiology and weight

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;HIV/AIDS;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE The proposed study aims to conduct a randomized controlled trial to empower people living with HIV to be critical agents of behavior change within their social networks in Uganda, where virtually every family is touched by someone living with HIV. Positioning people living with HIV as central to the solution for controlling (vs. causing) the HIV epidemic has the potential to reduce HIV stigma and improve HIV prevention behaviors at the individual, household, and network levels.

PI_NAMEs: BOGART, LAURA M;WAGNER, GLENN JOHN (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: acceptability and feasibility;Address;Advocacy;Advocate;aged;AIDS prevention;antiretroviral therapy;arm;attentional control;Behavior;behavior change;Caring;Client;Cognitive;Communicable Diseases;Communities;community advisory board;community engagement;condoms;Cost Effectiveness Analysis;Diffusion;Disclosure;empowerment;Epidemic;Family;fighting;Focus Groups;Friends;Funding;Government;group intervention;Health;Health Personnel;health training;High Prevalence;HIV;HIV risk;Household;Human immunodeficiency virus test;improved;Incidence;Individual;Information Networks;innovation;internalized stigma;Intervention;intervention effect;Investments;Mediating;member;men;National Institute of Mental Health;Outcome;Participant;peer;Penetration;Persons;Policy Maker;Politics;Positioning Attribute;pre-exposure prophylaxis;Prevalence;Prevention;primary outcome;Process;public-private partnership;Randomized;Randomized, Controlled Trials;recruit;Research;Risk;secondary outcome;sex;social;social engagement;social influence;Social Network;social stigma;Surveys;Testing;theories;therapy development;tool;Touch sensation;Training;Uganda;Unsafe Sex;uptake;Viral;Viral Load result;virtual;Woman;Work

PROJECT_TITLE: Controlled Trial of Game Changers: A Group Intervention to Train HIV Clients to be Change Agents for HIV Prevention in Uganda

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Sexually Transmitted Infections

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative This project is of direct relevance to Alzheimer’s disease, as we are studying the genetic variance found in immune populations from the CNS, microglia. We will be examining how the genetic variance that has been associated to Alzheimer’s disease modulates the immune response to HSV-1 infection. We will be examining the interaction of HSV-1 infection, immune cells, and genetic susceptibility to Alzheimer’s disease.

PI_NAMEs: BRADSHAW, ELIZABETH M (contact);ELYAMAN, WASSIM ;VARDARAJAN, BADRI N

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acceleration;Age;age related neurodegeneration;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Anti-viral Agents;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;Autopsy;Bacteria;biobank;Blood Vessels;CD8-Positive T-Lymphocytes;cell type;Cells;Central Nervous System;Cerebrospinal Fluid;Childhood;Chlamydophila pneumoniae;Clinical;Clinical Trials;Clonal Expansion;Code;cohort;Communities;Computational Biology;Dementia;Disease;DNA;endophenotype;Epidemiology;epidemiology study;Episodic memory;Etiology;Family member;fitness;Functional disorder;Gene Modified;Genes;Genetic;genetic association;Genetic Diseases;Genetic Predisposition to Disease;genetic risk factor;Genetic study;genetic variant;genome wide association study;Genotype;Goals;Height;Herpes Labialis;Herpesviridae;Herpesvirus 1;HHV-6A;Hippocampus;Human;Human Herpesvirus 4;Human Herpesvirus 7;human pathogen;Immune;Immune response;Immune system;Immune System Diseases;Immunology;immunoregulation;Impaired cognition;Impairment;In Vitro;in vitro Model;Individual;Infection;Infectious Agent;Innate Immune System;Late Onset Alzheimer Disease;Link;Measures;Mediating;Membrane Proteins;Memory;Microglia;monocyte;mouse model;Neurodegenerative Disorders;novel;pathogen;Pathogenesis;pathogenic bacteria;pathogenic fungus;pathogenic virus;Pathogenicity;Pathology;Phenotype;Play;PLCG2 gene;Population;Porphyromonas gingivalis;Predisposition;Productivity;Proteins;Research Personnel;response;Risk Factors;Role;Senile Plaques;Signal Transduction;skills;SPI1 gene;Suggestion;Susceptibility Gene;Symptoms;T cell infiltration;T-Cell Activation;T-Lymphocyte;Technology;TLR2 gene;tool;transcriptomics;Universities;Validation;Viral;virology;Virus;Washington;Work

PROJECT_TITLE: Intersection of HSV-1 and microglial genetics in AD


NIH_SPENDING_CATS: Cancer

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narratives The proposed study will utilize cryogenic Electron Microscopy (cryoEM) techniques and biochemical experiments to understand the structure and function of oncoprotein LAPTM4b. The invaluable results will provide the first mechanistic insights of this protein in cancer cell proliferation. The results from the proposed study will guide structure-based cancer drug development and advance the field for better therapeutics.

PI_NAMEs: SAE HER, AMPON  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Affect;Amino Acid Transporter;analog;Antineoplastic Agents;Apoptosis;Binding;Biochemical;Biochemistry;Biological Assay;cancer cell;cancer drug resistance;career;Career Choice;Carrier Proteins;Catabolic Process;Cell Membrane Proteins;Cell Proliferation;Cells;Ceramides;Complex;Cryoelectron Microscopy;Data;design;detection of nutrient;Disease;Drug Design;drug development;electron diffraction;Environment;Essential Amino Acids;experimental study;Foundations;FRAP1 gene;Gatekeeping;Goals;In Vitro;inhibitor;insight;Integral Membrane Protein;interest;Kinetics;Lead;Leucine;Link;Lipids;Liposomes;Lysosomes;Malignant Neoplasms;Measures;Membrane;Membrane Proteins;Molecular;Molecular Conformation;Molecular Probes;Mutation;Neoplasm Metastasis;neoplastic cell;Oncoproteins;Outcome;overexpression;particle;Pathway interactions;Persons;Phosphorylation;prevent;Process;Prognosis;protein complex;Protein Isoforms;protein protein interaction;protein structure;Proteins;proteoliposomes;Public Health;reconstitution;recruit;Regulation;Research;Research Personnel;Resolution;Resources;Signal Transduction;structural biology;Structure;Structure-Activity Relationship;Surface;Techniques;Therapeutic;tool;Training;training opportunity;uncontrolled cell growth;Up-Regulation;uptake;Work

PROJECT_TITLE: Structural Insights into Leucine Transport for mTORC1 Activation


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: PROJECT NARRATIVE This proposal will investigate the mechanisms regulating the function of blood-forming stem cells during fetal development. The findings will be used to improve the prevention and treatment of cancer and disorders of the blood and immune system, with emphasis on disorders that may originate in early life.

PI_NAMEs: FORSBERG, CAMILLA  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Activities of Daily Living;Adult;Amaze;Award;Biological Assay;Biological Models;cancer therapy;Cell Lineage;cell type;Cells;Chromatin;Clonal Hematopoietic Stem Cell;CRISPR interference;CRISPR-mediated transcriptional activation;Development;Disease;epigenetic memory;Epigenetic Process;experimental study;Exposure to;fetal;Fetal Development;Fetal Liver;fetal stem cell;fetus cell;Gene Expression Profile;Genes;Genetic Transcription;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell differentiation;hematopoietic stem cell fate;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell subsets;Hematopoietic stem cells;Immune;Immune System Diseases;improved;In Situ;in vivo;Informal Social Control;Inherited;insight;Life;life span;Link;Lymphoid;Lymphoid Cell;Malignant Neoplasms;Mediating;Molecular;molecular dynamics;Molecular Profiling;mouse model;multipotent cell;novel;novel strategies;Output;Population;post-transplant;preservation;Prevention;Property;reconstitution;Regulation;Research;Role;self-renewal;single-cell RNA sequencing;stem cell biology;stem cell fate;stem cell function;stem cell population;stem cells;Stress;System;Testing;tool;transcriptome;Transgenic Model;Transplantation;Work

PROJECT_TITLE: Role and Regulation of a Novel, Developmentally Restricted Hematopoietic Stem Cell

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Congenital Structural Anomalies;Gene Therapy;Genetics;Myasthenia Gravis;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: TOWSON

ORG_NAME: AMPLO BIOTECHNOLOGY, INC.

PHR: NARRATIVE ColQ CMS is a rare neuromuscular disorder with no cure associated. Severe limb-girdle pattern of weakness, choking spells, respiratory insufficiency, severe scoliosis present early on during the disease progression with early death not uncommon among these patients. This project aims to validate the safety and efficacy of a new gene therapy product for ColQ CMS able to transform clinical practice from chronic administration of drugs to alleviate symptoms to a one-off, non-pharmacological treatment, administered through a single intravenous injection. The project is expected to unveil important insights on the mechanism of action of Neuromuscular Junction as well to explore the existence of a shared gene therapy development pathway for CMS.

PI_NAMEs: MASELLI, RICARDO ANIBAL;SEPULVEDA, PATRICIO  (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Acetylcholinesterase;Acetylcholinesterase Inhibitors;Address;Adrenergic Agonists;Adult;Affect;Albuterol;Animal Model;assay development;Award;beta-2 Adrenergic Receptors;Biological Assay;Biotechnology;Cardiomyopathies;Caring;Cessation of life;Child;Childhood;Choking;Chronic;Circulation;Clinical;clinical development;clinical practice;Collaborations;Collagen;Congenital Myasthenic Syndromes;cost;Defect;Dependence;Dependovirus;design;Deterioration;Developed Countries;Development;Disease;Disease Management;Disease Progression;DNA Sequence Alteration;Dose;drug development;efficacy study;efficacy validation;Eligibility Determination;emerging adult;Ensure;Enteral Feeding;Ephedrine;Exertion;Exposure to;gene delivery system;gene therapy;Goals;Health;Heart failure;Hemophilia A;Human;improved;Inflammatory Response;Inherited;inhibitor;insight;Intervention;Intramuscular Injections;Intravenous;intravenous administration;intravenous injection;Investments;Lead;Left;Limb structure;Limb-Girdle Muscular Dystrophies;Liver;manufacture;Methods;Morphology;Motor;mouse model;Mus;Muscle;Muscle Weakness;MUSK gene;Mutation;Myasthenia;Myocardial Ischemia;Neuromuscular Diseases;Neuromuscular Junction;Neuromuscular Junction Diseases;neuromuscular transmission;nonhuman primate;Nonpharmacologic Therapy;Ontario;Outcome;Pathologic;Pathway interactions;patient population;Patients;Pattern;Pediatric Hospitals;Persons;Pharmaceutical Preparations;Phase;Phenotype;Phosphorylation;Physicians;Population;pre-clinical;preclinical development;preclinical efficacy;preclinical study;Preparation;Prevalence;Procedures;Process;Production;programs;promoter;Proteins;Quality of life;Rare Diseases;recruit;reduce symptoms;Refractory;respiratory;Respiratory Failure;Respiratory Insufficiency;response;Safety;scoliosis;side effect;Signal Transduction;Small Business Innovation Research Grant;Small Business Technology Transfer Research;spelling;Standardization;symptom management;symptomatic improvement;Symptoms;Synapses;Tachycardia;Testing;Therapeutic;therapy development;tibialis anterior muscle;Time;Toxic effect;Toxicology;Transgenes;transmission process;United States National Institutes of Health;Universities;Validation;Variant;vector;vif Genes;Vocal Cord Paralysis

PROJECT_TITLE: Targeted ColQ gene therapy for Congenital Myasthenic Syndromes