NIH_SPENDING_CATS: Comparative Effectiveness Research;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE This project seeks to address the urgent need for improved methods in trial sequential analysis to enhance the reliability and timeliness of living evidence derived from systematic reviews and meta-analyses. By developing innovative approaches that accurately establish decision boundaries in early-stage cumulative meta-analyses, this project aims to overcome the limitations of existing methods for trial sequential analysis. The proposed methods will effectively handle between-study heterogeneity and reduce the risk of prematurely terminating living systematic reviews, ensuring robust utilization of trial sequential analysis in assessing living evidence and guiding decisions on the necessity of new randomized controlled trials.

PI_NAMEs: LIN, LIFENG  (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Address;Adoption;Area;Attention;Benefits and Risks;career;Clinical;Communicable Diseases;Communities;Comparative Effectiveness Research;Computer software;Confidence Intervals;COVID-19 pandemic;Data;Data Set;Decision Making;Dedications;design;efficacy evaluation;Ensure;Evaluation;Evidence Based Medicine;Futility;Heterogeneity;improved;inclusion criteria;Infectious Diseases Research;innovation;insight;Instruction;interest;Intervention;Investigation;Malignant Neoplasms;Medical;Meta-Analysis;Methods;Monitor;Normalcy;novel;open source;Patients;Performance;Pharmaceutical Preparations;Placebos;Play;Population;premature;preventive intervention;Process;Productivity;Publications;Randomized, Controlled Trials;Research;Resource Allocation;Resources;response;Risk Reduction;Role;simulation;Statistical Methods;statistics;stem;systematic review;Therapeutic;Time;tool;treatment effect;Treatment Effectiveness;Treatment Efficacy;Update;user friendly software;user-friendly;Vaccines;Validation;wasting

PROJECT_TITLE: Advanced Methods and Software for Trial Sequential Analysis in Living Systematic Reviews

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-P (90)]


ADMINISTERING_IC: OD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE  Traumatic injuries, fibrotic diseases, scarring, chronic inflammation, and aging impact multiple organ systems affect millions of people worldwide at great economic cost. We propose to develop multiple genetic technologies to genetically manipulate Acomys (Spiny mice), the only known mammalian species that with significant, systemic, regenerative non-fibrotic wound healing capacity as adults. These technologies will enable us to unlock the mechanisms driving mammalian regenerative healing programs to guide urgently needed new therapies for human regenerative medicine.

PI_NAMEs: MILLEN, KATHLEEN JOYCE (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acceleration;Acomys;Adult;Affect;Aging;Alleles;animal old age;Animals;Antibodies;appendage;Automobile Driving;Balaena;Biological;Biology;Body System;Brothers;Cell Culture Techniques;Cell Line;Cells;Chimera organism;Chimerism;Chromosomes;Chronic;Cicatrix;Clustered Regularly Interspaced Short Palindromic Repeats;Color;combat;Communication;Communities;design;Development;Disease;DNA Repair;Ear;economic cost;Electroporation;Embryo;embryonic stem cell;Epitopes;experimental study;Female;Fibroblasts;Fibrosis;Gene Expression;gene function;Gene Transfer Techniques;Generations;Genetic;genetic manipulation;Genetic Research;genetic technology;Genome;genome editing;genome-wide;global health;healing;healthy aging;Homeostasis;Human;Human Biology;human old age (65+);Image;Implant;improved;In Situ;In Vitro;in vivo;Inbreeding;indexing;Inflammation;Injury;juvenile animal;Knowledge;Laboratories;Lentivirus;Malignant Neoplasms;Mammalian Oviducts;Mammals;Menstruation;Methodology;Methods;model organism;Modeling;Molecular Genetics;Mus;nanopore;Natural regeneration;Natural Selections;nerve stem cell;neural;novel;novel therapeutics;nucleic acid delivery;Organ;Organism;Organoids;Persons;programs;Property;Protocols documentation;Pseudopregnancy;Publishing;Rattus;Reagent;Recording of previous events;reference genome;regeneration model;regenerative;regenerative biology;Regenerative capacity;regenerative healing;Regenerative Medicine;Regenerative research;regenerative therapy;Reproductive Physiology;Research;Research Personnel;Resources;Rest;Rodent;single-cell RNA sequencing;Sister;Skin;Study models;success;Superovulation;Technology;Testing;Tissues;tool;trait;Transgenic Animals;Translations;Traumatic injury;United States Department of Agriculture;wound healing

PROJECT_TITLE: Establishing Acomys as a genetic platform for regeneration research

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The U01 study will mechanistically characterize tumor-macrophage hybrid cells as a new and unexpected player in metastatic castration-resistant prostate cancer (mCRPC). Molecular profiling of these malignant cells may reveal their Achilles' heels, presenting opportunities to develop new agents for treating this mCRPC subtype.

PI_NAMEs: HUANG, TIM H.-M. (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Adenocarcinoma;Adopted;advanced prostate cancer;androgen independent prostate cancer;Atomic Force Microscopy;biophysical analysis;Blood;Blood Cells;Blood Circulation;bone;c-myc Genes;cancer cell;Cancer Patient;cancer subtypes;Castration;cell killing;Cell Line;Cells;Characteristics;Chest;Circulation;Clinical;cohort;coping;Data;Deformity;Deposition;Distant;Distant Metastasis;Effector Cell;Embolism;Endowment;Event;Experimental Models;Family;genetic signature;Genetic Transcription;Growth;Half-Life;hemodynamics;Human;Hybrid Cells;Hybrids;Immune;Immune Evasion;Immune response;Immune system;Immunologic Surveillance;Immunophenotyping;In Situ;In Vitro;in vivo;Inherited;inhibitor;Integrins;Intrinsic factor;knock-down;liquid biopsy;Liquid substance;lymph nodes;Macrophage;Malignant - descriptor;Malignant neoplasm of prostate;Mechanical Stress;mechanotransduction;Mediating;Mesenchymal;Microfluidic Microchips;Molecular Profiling;Motility;mouse model;Mus;Neoplasm Circulating Cells;neoplastic cell;New Agents;novel;Oncogenic;Organ;Outcome;Pathway interactions;Patients;Phagocytosis;pharmacologic;Phenotype;Population;pressure;Primary Lesion;prognostic;programs;Property;prostate cancer cell;prostate cancer metastasis;Proteomics;Recurrence;Resistance;Role;Sampling;shear stress;Signal Transduction;Site;small hairpin RNA;Stress;System;Therapeutic;therapy resistant;Thinking;transcriptomics;transdifferentiation;Travel;trend;tumor;tumor initiation;tumor microenvironment

PROJECT_TITLE: The role of tumor-macrophage hybrid cells in prostate cancer metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-4 (J1)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: ALBANY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: ALBANY MEDICAL COLLEGE

ORG_STATE: NY

PHR: NARRATIVE The Albany Medical College (AMC) Imaging Core Facility requests funds for the purchase of an Olympus FVMPE-RS multiphoton microscope for intravital microscopy and large tissue samples and 3D model imaging. This instrument is configured to cover the main requirements of all major and minor users, while allowing for future upgrades and additions through institutional or individual investments. Through the acquisition of the Olympus FVMPE-RS multiphoton microscope, we will leverage the state-of-the-art animal facility at AMC to provide the needed access to multiphoton and intravital microscopy to NIH-supported investigators within AMC and at other research institutions in the Albany Capital District, fostering cross-institutional collaborations among NIH- supported investigators at these institutions.

PI_NAMEs: BARROSO, MARGARIDA  (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: animal facility;Animals;Biological Process;Blood Vessels;cancer cell;Capital;Cell Communication;cell motility;Collaborations;Color;Complement;Complex;Core Facility;design;detector;Development;Disease;disease model;Drug Delivery Systems;Fostering;Funding;Future;Hybrids;Image;Immune;In Vitro;in vitro Model;Individual;insight;Institution;instrument;intravital microscope;intravital microscopy;Investments;Lasers;Lung Diseases;Malignant Neoplasms;medical schools;Microscope;Minor;mouse model;multi-photon;multiphoton microscopy;neuropathology;neurovascular unit;Penetrance;Perfusion;Research;Research Personnel;Resolution;systemic inflammatory response;three-dimensional modeling;Time;Tissue Sample;United States National Institutes of Health;Vascular Diseases

PROJECT_TITLE: Multiphoton intravital microscope

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Extracellular vesicles (EVs) are released from all cells and contain bioactive cargo that robustly alters signaling in the receiving cell. The ability to engineer EVs holds promise for the next generation of therapeutics, yet the methods to do so are underdeveloped. This proposal will utilize the endothelial cell’s ability to load extracellular material into EVs, to efficiently customize EV cargo for the treatment of disease.

PI_NAMEs: CREWE, CLAIR  (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: 2019-nCoV;Albumins;Alzheimer's Disease;Attention;Back;Binding;Biological Models;Biomedical Engineering;Biotechnology;cardioprotection;Cardiovascular Diseases;Cell Culture Techniques;cell injury;Cell surface;cell type;Cells;Chronic Disease;Clinic;clinical application;clinical translation;Combined Modality Therapy;common treatment;Culture Media;Cytoplasm;Diffusion;Disease;Distal;DNA;drug development;drug discovery;Drug Targeting;Electroporation;Encapsulated;Endothelial Cells;Engineering;Enzymes;Experimental Designs;experimental study;extracellular;extracellular vesicles;Fluorescein-5-isothiocyanate;Genetic Transcription;Human;improved;In Vitro;in vivo;Incubated;Injections;innovation;Intervention;Investments;ischemic injury;L Cells;lipid nanoparticle;Lipids;macromolecule;Mesenchymal Stem Cells;Messenger RNA;Methods;MicroRNAs;mouse model;Mus;Myocardial Infarction;Myocardial Ischemia;nanosized;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;Organ;Parents;Pathway interactions;Peptides;Permeability;Pharmaceutical Preparations;Pharmacology;Post-Translational Protein Processing;prevent;Process;Production;Publishing;receptor;regenerative;Regulation;Reperfusion Injury;Research;Research Personnel;restraint;RNA;RNA vaccine;Side;Signal Transduction;Signaling Protein;Specificity;success;Techniques;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapeutic nanoparticles;therapeutically effective;Time;Tissues;Toxic effect;transcytosis;Translations;Treatment Efficacy;Vascular Endothelial Cell;Vesicle;vesicular release;Work

PROJECT_TITLE: Endothelial cell-assisted extracellular vesicle bioengineering for cytoplasmic delivery of therapeutic molecules

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: EAST LANSING

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE New classes of antibacterials are required to combat the spread of antimicrobial resistance (AMR). AMR is an underlying factor in ~5 million deaths worldwide each year and deaths due to resistant microbes are predicted to overtake cancer by 2050. Novel classes of antibacterials have the potential to combat AMR because existing resistance to these new agents is not predicted to be widespread.

PI_NAMEs: ABRAMOVITCH, ROBERT B (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Aminoglycosides;analog;Anti-Bacterial Agents;Anti-malarials;antimicrobial;Antimicrobial Resistance;Antimycobacterial Agents;Bacteria;beta-Lactams;Biological Availability;Cells;Cessation of life;Clinical Trials;Collection;combat;Data;Development;Dose;Drug Kinetics;Drug or chemical Tissue Distribution;Enterococcus faecalis;Escherichia coli;Fluoroquinolones;Future;Gene Expression Profiling;Genes;Genus Mycobacterium;Goals;Growth;Half-Life;Human;In Vitro;in vitro Model;Infection;Iron;Malignant Neoplasms;meter;Microbe;mouse model;Mycobacterium abscessus;Mycobacterium smegmatis;Mycobacterium tuberculosis;New Agents;novel;Oral;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Peroxides;Predisposition;priority pathogen;Property;Proteus vulgaris;Regulation;Resistance;Safety;Staphylococcus aureus;Structure-Activity Relationship;Testing;tuberculosis treatment

PROJECT_TITLE: Defining the antibacterial activities of ozonides

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: BATON ROUGE

ORG_DEPT: BIOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: The central goal of this proposal is to develop a protein platform comprising two bacterial toxins targeting lung cancer cells that overexpress the glycan Sialyl Lewis X (SLeX), which correlates with cancer metastasis. One bacterial toxin binds SLeX and delivers the other bacterial toxin, a “killing” component, into cancer cells. The outcome of this study will provide a potential novel therapeutic approach against cancers overexpressing SLeX prone to metastasis.

PI_NAMEs: CHEN, CHEN  (contact)

PROGRAM_OFFICER_NAME: SALOMON, RACHELLE

PROJECT_TERMS: A549;Adhesions;ADP ribosylation;Affinity;anti-cancer;Antibodies;anticancer activity;Antigens;Antineoplastic Agents;Bacteria;Bacterial Toxins;Binding;Brain;Breast;cancer cell;Cancer cell line;Cancer Etiology;Cancer Patient;cancer therapy;cancer type;Carbohydrates;Cell Death;Cell Death Induction;Cell Line;Cell Migration Inhibition function;cell motility;Cells;Cervix Uteri;Cessation of life;Chimeric Proteins;Clinical Research;Cytosol;cytotoxicity;Diagnosis;Disease;Distant Metastasis;Economics;Emotional;Engineering;Epithelial Cells;Exhibits;Genus staphylococcus;Goals;H1299;high risk;Human;Hypoxia;immunogenicity;Immunotoxins;In Vitro;Invaded;Kidney;Liver;Lung;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Melanoma;Metastatic malignant neoplasm to brain;migration;Mutation;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;novel therapeutic intervention;novel therapeutics;Outcome Study;Ovary;overexpression;Pancreas;Patients;Penetration;Peptide Elongation Factor 2;Pharmaceutical Preparations;Plants;Polysaccharides;Primary Neoplasm;Prognosis;Property;Prostate;Proteins;Pseudomonas aeruginosa toxA protein;receptor binding;Recurrence;Resistance;sialyl Lewis x;Solid Neoplasm;Specificity;Stomach;Superantigens;Survival Rate;Targeted Toxins;Testing;Therapeutic;Time;Toxin;tumor;tumor diagnosis;tumor hypoxia;tumor metabolism;Tumor-Associated Carbohydrate Antigens;uncontrolled cell growth;United States;Work

PROJECT_TITLE: Taming two bacterial toxins into an anticancer agent with "sweets"

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: IOWA CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE For patients with inherited retinal degeneration who have lost most of their photoreceptor cells and no longer have useful vision, therapeutic autologous photoreceptor cell replacement is one of the most promising approaches currently being developed. While robust retinal differentiation protocols that enable production of clinical grade 3D retinal organoids exist, validated methods for reproducibly isolating transplantable photoreceptor cells are required. In this application, we propose experiments designed to support complete characterization of the retinal cell product following staged organoid dissociation and fabrication of a continuous flow organoid dissociation and microfluidic photoreceptor cell enrichment device to facilitate production of a highly pure clinical grade therapeutic.

PI_NAMEs: TUCKER, BUDD A (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Amacrine Cells;Antibodies;Atomic Force Microscopy;Autologous;Back;Blindness;Buffers;Cell Count;Cell Death;cell motility;cell replacement therapy;Cell Separation;Cell Therapy;cell type;Cells;Clinical;clinically relevant;Cyclic GMP;Data;Degenerative Disorder;design;Devices;Diagnosis;differentiation protocol;Disease;Dissociation;Electrodes;Enzymes;Experimental Designs;Eye;fabrication;Feedback;Fluorescence-Activated Cell Sorting;ganglion cell;gene therapy;Generations;Geometry;Good Manufacturing Process;horizontal cell;Immunosuppression;in vivo;Individual;Inherited;inherited retinal degeneration;interest;Label;magnetic beads;manufacture;manufacturing process;manufacturing run;mechanical properties;Methods;Microfluidics;Molecular Diagnosis;Monitor;Neural Retina;Neuroglia;optimal treatments;Organoids;patient derived induced pluripotent stem cells;Patients;Photoreceptors;Population;precursor cell;Preparation;pressure;Process;Production;programs;Protocols documentation;Reagent;real time monitoring;Recovery;Replacement Therapy;Reporting;Reproducibility;Retina;retina transplantation;Retinal Degeneration;Retinal Photoreceptors;Retinitis Pigmentosa;segregation;Series;Shapes;single-cell RNA sequencing;Sorting;Source;Standardization;Stargardt's disease;Structure of retinal pigment epithelium;Surface Antigens;System;Testing;Therapeutic;Time;Tissues;Transplantation;Treatment outcome;Validation;Vision

PROJECT_TITLE: Label-free microfluidic isolation of patient iPSC-derived photoreceptor cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative This project will enhance basic genomic data from the 2014 wave of the Child Development Supplement to the Panel Study of Income Dynamics in a number of important ways. It will create new genomic measures, make them available to the research community free of charge, and promote their use through comprehensive documentation and outreach efforts. This project will allow researchers to use these new genomic measures to answer crucial scientific questions about how genetic propensity and social environment intervene to shape health, behavior, and well-being.

PI_NAMEs: ZHAO, WEI  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Address;Archives;Behavior;Behavioral;behavioral economics;behavioral outcome;Body mass index;Book Chapters;Caregivers;Charge;Child;Child Development;Childhood;Collaborations;Collection;Communities;Contracts;Data;data archive;Data Set;Documentation;economic outcome;Economics;Education;Environment;experience;Family;Family member;Family Relationship;Fathers;Foundations;Future;gene environment interaction;Generations;Genes;Genetic;genetic analysis;genetic association;genetic pedigree;Genetic Predisposition to Disease;genetic variant;Genome;genome-wide;genomic data;Genomics;Genotype;Goals;Health;health economics;Height;improved;indexing;intergenerational;large datasets;Life Cycle Stages;Longitudinal Surveys;Measures;Mental Depression;Methods;Mothers;National Institute of Child Health and Human Development;offspring;Outcome;outreach;panel study of income dynamics;Paper;Parents;Personal Satisfaction;Play;polygenic risk score;Population;primary caregiver;prospective;Publishing;Reporting;repository;Research;Research Design;Research Personnel;Role;saliva sample;Sampling;Shapes;Smoking;social;Social Environment;Social outcome;Social Sciences;socioeconomics;Stratification;Structure;Time;trait;transition to adulthood;Work

PROJECT_TITLE: Enhancing and Archiving Genomic Data of the PSID Child Development Supplement

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative  This project seeks to test the effectiveness and feasibility of delivering a brief digital intervention, designed to rehabilitate self-worth through classical conditioning exercises, as an adjunct to intravenous ketamine treatments delivered by embedded providers in real-world ketamine clinics. Ketamine, a fast-acting antidepressant, may rapidly prime the brain for helpful forms of learning, and we seek to deliver such learning efficiently, through portable, low-cost, digital techniques. This work could ultimately lead to the ability to treat depression more efficiently and effectively.

PI_NAMEs: MATHEW, SANJAY J (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Acute;adaptive learning;Adoption;anti-depressive agents;antidepressant effect;arm;Association Learning;Atrophic;Behavior Therapy;blind;Brain;Characteristics;Clinic;Clinical;clinical translation;Cognition;Cognitive;cognitive training;Communities;cost;cost effective;Data;Data Collection;Depressed mood;depressed patient;depressive symptoms;design;Diagnostic;digital;digital intervention;digital treatment;Dose;Drug Controls;Educational Intervention;Effectiveness;effectiveness testing;effectiveness-implementation RCT;efficacy study;Enrollment;evidence base;Exercise;experience;Failure;flexibility;follow-up;Friends;Hippocampus;Home;Hour;Hybrids;implementation evaluation;Implicit Association Test;improved;indexing;Individual;information processing;Infusion procedures;Intervention;Interviewer;Intravenous;Intravenous Anesthetics;Ketamine;Learning;Maintenance;Measures;Medical;Mental Depression;Methods;Molecular;Molecular Profiling;Moods;Neurocognitive;Neuronal Plasticity;Neurons;novel;Outcome;outcome prediction;Outpatients;Patient Preferences;Patients;Pattern;performance based measurement;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Actions;Phase;placebo group;portability;Prefrontal Cortex;profiles in patients;Proliferating;Property;Protocols documentation;Provider;Randomized;recruit;Research;Resistance;response;Risk Factors;Saline;Self Administration;Series;Severities;Site;Symptoms;synaptic depression;Techniques;Testing;Time;Training;Training Technics;Treatment Protocols;treatment-resistant depression;Uninsured Medical Expense;Work

PROJECT_TITLE: 2/2 A brief automated neurocognitive training to enhance the real-world impact of ketamine's rapid antidepressant effect

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Precision Medicine

ORG_CITY: LEXINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative This project aims to develop new statistical methods for identification and evaluation of biomarkers that can predict treatment effect for cancer patients. The success of this project will enable predictive biomarker analysis from non-randomized clinical trial data, and thus will have a direct impact on drug development and clinical practice.

PI_NAMEs: CHEN, LI  (contact);WANG, CHI

PROGRAM_OFFICER_NAME: GUAN, PING

PROJECT_TERMS: absorption;Acceleration;Accounting;Address;Area Under Curve;arm;Biological Markers;biomarker evaluation;biomarker validation;cancer clinical trial;Cancer Etiology;Cancer Patient;cancer therapy;candidate marker;Case Study;Cessation of life;Characteristics;checkpoint therapy;Clinical;Clinical Drug Development;clinical effect;clinical practice;Clinical Trials;cohort;Data;Death Rate;design;drug development;Evaluation;experience;Failure;FDA approved;Gene Expression;Generations;Goals;high dimensionality;Immune checkpoint inhibitor;improved;interest;Joints;Letters;Malignant Neoplasms;Measures;Methods;Modeling;Natural History;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Outcome;Pathologic;patient stratification;Patients;Phase;Phase II Clinical Trials;phase II trial;phase III trial;precision medicine;precision oncology;Prediction of Response to Therapy;predictive marker;predictive signature;Progression-Free Survivals;Randomized;randomized trial;randomized, clinical trials;Refractory;refractory cancer;Relapse;relapse patients;Reporting;Research Personnel;Sample Size;semiparametric;skills;Standardization;standardize measure;Statistical Methods;Statistical Models;Subgroup;success;Suggestion;targeted treatment;Testing;Therapy trial;Time;treatment effect;Treatment Efficacy;tumor;user friendly software;user-friendly;Validation;web app

PROJECT_TITLE: Statistical Methods for Identification and Evaluation of Predictive Biomarkers in Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-5 (J1)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering;Cancer;Machine Learning and Artificial Intelligence;Nanotechnology

ORG_CITY: RIVERSIDE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: Project Narrative The poor understanding of the impact of NPs-protein corona interactions on the biodistribution of NPs results in the inefficient delivery of NPs to target solid tumors. The objective of this proposal is to develop an artificial intelligence (AI)-assisted model to improve tumor delivery efficiency by considering the impact of NPs-protein corona interactions. This project is relevant to public health because the resulting models and the methods gained from the proposed research will help address the design of smart nanomedicine and improve cancer therapy with optimized nanomedicine.

PI_NAMEs: CHOU, WEI-CHUN  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: absorption;Address;Advanced Development;Area;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Biodistribution;Biological;biological systems;cancer therapy;Characteristics;Complex;Computer Models;Data;Data Set;Databases;design;Development;Differential Equation;Drug Delivery Systems;drug discovery;Drug Kinetics;Endowment;Fingerprint;generative adversarial network;generative models;Human;image reconstruction;improved;in vivo;Kinetics;Language;Lead;Learning;Libraries;Liquid substance;Machine Learning;Malignant Neoplasms;Marketing;Medical Research;Methodology;Methods;Modeling;nano;nanocarrier;nanomedicine;nanoparticle;nanoparticle delivery;nanotoxicity;network models;neural;novel;Outcome;Pattern;Permeability;Pharmaceutical Preparations;pharmacokinetic model;preclinical trial;predictive modeling;Property;protein complex;Protein Fingerprints;Proteins;Public Health;Published Database;Publishing;Research;Route;Site;Solid Neoplasm;stem;symposium;System;Technology;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;tool;Training;Treatment Efficacy;tumor;uptake;user-friendly;virtual;Work

PROJECT_TITLE: Computational Modeling on the Interaction of Nanomedicine with Protein Corona and Its Impact on Tumor Delivery Efficiency

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Efforts to address the high burden of mental health conditions have been hindered by the lack of data to match patients to treatments, resulting in delayed or insufficient care and a growing public health burden. The proposed research study will establish baseline factors and track behavior and clinical markers among individuals as they enter and progress through mental health treatment. Ultimately, this study seeks to develop scalable treatment decision tools that can be readily adopted and hasten recovery for the millions of Americans suffering from mental health conditions.

PI_NAMEs: BOHNERT, AMY S B (contact);FRITSCHE, LARS ;SEN, SRIJAN

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;Algorithms;American;analytical tool;Appointment;Behavior;behavior measurement;behavior prediction;Behavioral;Caring;Cellular Phone;Clinic;Clinical;Clinical Markers;Clinical Trials;Cognitive Therapy;cohort;community advisory board;Complex;Data;Data Coordinating Center;data harmonization;data sharing;Data Sources;design;Development;Diagnostic;digital intervention;digital treatment;Dimensions;disability;diverse data;Effectiveness;Emotional;Ensure;Evaluation;evidence base;experience;FAIR principles;Genetic Databases;genomic data;Genomics;Goals;Healthcare Systems;improved;improved outcome;Individual;Infrastructure;innovation;innovative technologies;Intervention;Lead;Machine Learning;machine learning algorithm;Measures;medical specialties;Mental Health;Mental Health Services;Methods;Michigan;Mindfulness Training;mobile computing;Modeling;multidimensional data;Outcome;Outpatients;Participant;patient population;patient response;Patients;Perception;personalized approach;personalized medicine;personalized predictions;Persons;Pharmaceutical Preparations;Physical activity;Positioning Attribute;Prediction of Response to Therapy;predictive modeling;preference;programs;Psychiatry;Psychotherapy;Public Health;Quality of life;Randomized;Recommendation;Records;Recovery;recruit;reduce symptoms;research study;response;Sampling;Signal Transduction;Sleep;social engagement;Stream;Surveys;Symptom Burden;symptomatic improvement;Technology;Testing;Time;tool;Translating;treatment trial;Validation;wearable device;wearable sensor technology;Work

PROJECT_TITLE: COMPASS: A comprehensive mobile precision approach for scalable solutions in mental health treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (01)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: WALTHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Engagement in daily activities is thought to be important for the maintenance of cognitive function and resilience to age-related pathology, however, despite the potential importance of engaging in activities, older adults actually report decreased participation in activities in daily life. This project will provide critical and detailed information regarding the behavioral and neurobiological mechanisms of daily life activity participation in older adults and its relationship to Alzheimer’s disease pathology. Such information has clear relevance for public health, by improving understanding of how and why aging might lead to changes in activity participation, and in developing appropriate interventions to address such changes.

PI_NAMEs: BERRY, ANNE SHIVELY (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Address;Adult;Affect;Affective;Age;age related;Age related pathologies;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Attention;Behavioral;Behavioral Mechanisms;behavioral study;Berry;Binding;Biological;biological systems;Brain;brain health;Cognition;Cognitive;cognitive ability;cognitive enhancement;cognitive function;cognitive performance;cooking;Coupled;Data;Development;Ecological momentary assessment;emotional experience;environmental enrichment for laboratory animals;experience;Exposure to;Foundations;Future;Health;high resolution imaging;Human;human old age (65+);improved;in vivo;Individual;Individual Differences;innovation;insight;interest;Intervention;Investigation;Learning;Life;Life Experience;life span;Link;Location;locus ceruleus structure;Longitudinal Studies;Magnetic Resonance Imaging;Maintenance;Measurement;Measures;Medial;medial temporal lobe;Mediating;Memory;Methods;middle age;mobile computing;Monitor;motivational intervention;multimodality;neurobiological mechanism;neuroimaging;neuromechanism;norepinephrine system;novel;older adult;Participant;Pathology;Pattern;Persons;Phase;Play;Positron-Emission Tomography;pre-clinical;preservation;Protocols documentation;public health relevance;Reporting;Research;resilience;Resolution;response;Rodent Model;Sampling;sensor technology;Site;Structure;Targeted Research;tau function;tau mutation;tau Proteins;Temporal Lobe;Testing;tool;ultra high resolution;Well in self;Work

PROJECT_TITLE: Aging, activity diversity, and brain health

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Circadian and sleep disturbances are a common co-morbidity in neurodevelopmental disorders. The goal of this proposal is to discern the molecular mechanisms governing the developmental emergence of circadian behavior in order to provide insight into brain maturation in health and disease.

PI_NAMEs: POE, AMY ROSETTA (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Adult;Affect;Anatomy;Area;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavioral;Brain;Calcium;career development;Cells;circadian;Circadian Dysregulation;Circadian Rhythms;cognitive development;cognitive enhancement;Communication;comorbidity;Complement;Coupled;Coupling;Cues;Data;Development;Disease;Drosophila genus;Drosophila melanogaster;Environment;Exhibits;experience;experimental study;Faculty;feeding;fly;Foundations;Genetic;Goals;Health;Human Development;insight;Investigation;juvenile animal;knock-down;Knowledge;Larva;Learning;life span;long term memory;Machine Learning;Mammals;mature animal;Memory;Mentors;Metabolic;Modeling;Molecular;molecular clock;Monitor;Mushroom Bodies;mutant;neural;neural circuit;Neurobiology;Neurodevelopmental Disorder;Neurons;Neuropeptide Receptor;Neuropeptides;novel;nutrient deprivation;Nutritional;Output;Pattern;Periodicity;Phase;Play;Positioning Attribute;receptor;Research;response;RNA Interference;Role;Signal Transduction;Signaling Molecule;skills;Sleep;Sleep disturbances;sleep regulation;Sleep Stages;Stress;sugar;Symptoms;Techniques;tenure track;Testing;Time;Training;Vision

PROJECT_TITLE: Mechanisms for the emergence of rhythmic behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (02)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Pancreatic cystic lesions (PCLs) are incidentally identified on abdominal imaging studies in more than a million patients annually in the U.S. and they represent an opportunity for early detection of pancreatic adenocarcinoma. Most patients with PCLs have “indeterminate” cysts in which both the type and histologic grade are clinically and radiographically uncertain, and current diagnostic tests are inadequate and require large cyst fluid volumes that are often unavailable. We propose to evaluate our novel micro-volumetric two-tier classifier that can improve diagnostic accuracy of current cyst fluid tests, as well as to use novel tools including mPower, a radiology report search engine, to improve capture of patients with “missed” PCLs and, thereby, expand racial and ethnic diversity in our electronic Panc Cyst Registry.

PI_NAMEs: KIRKWOOD, KIMBERLY SAUNDERS (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Abdomen;Address;Aspartic Endopeptidases;Awareness;biobank;Biological Assay;Biological Markers;Blinded;Blood;Blood specimen;Carcinoembryonic Antigen;Carcinoma;Classification;Clinic;Clinical;clinical biomarkers;clinically relevant;cohort;Collection;community engagement;community partners;Cyst;Cyst Fluid;Data;Databases;design;Detection;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic tests;Early Detection Research Network;Early Diagnosis;Electronics;Endoscopic Ultrasonography;Equity;ethnic diversity;ethnic minority;Evaluation;Excision;Fine needle aspiration biopsy;follow-up;gastricsin;Geography;Goals;High grade dysplasia;Histologic;Histopathologic Grade;imaging study;improved;Individual;Institution;Lesion;Life Style;Liquid substance;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Methods;MRI Scans;Mucinous;Neoplasms;novel;Operative Surgical Procedures;overtreatment;Pancreatic Adenocarcinoma;Pancreatic carcinoma;Pancreatic Cyst;Pancreatic cystic neoplasia;Patients;Performance;Persons;Procedures;prospective;Proteins;Proteolysis;Proteomics;Provider;racial diversity;racial minority;radiological imaging;Radiology Specialty;recruit;Recruitment Activity;Registries;Reporting;repository;research clinical testing;Resected;Resources;Risk;sample collection;Sampling;Schedule;Screening for cancer;search engine;Shotguns;Standardization;surveillance imaging;systemic barrier;Testing;Time;tool;tumor;Unnecessary Surgery;Validation

PROJECT_TITLE: Using microvolumetric cyst fluid proteolysis for early detection of pancreatic cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-T (J2)]


NIH_SPENDING_CATS: Bioengineering;Drug Abuse (NIDA only);Genetics;Neurosciences;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: NARRATIVE Synapses–the connections between neurons–are the building blocks of the brain, enabling its ability to execute so many complex thoughts and behaviors. Measuring synapses in the primate brain has been especially challenging, because of the brain’s enormous size, and relative inaccessibility. This project will develop technology to meet this critical need, providing foundational tools for uncovering the circuitry of the primate brain.

PI_NAMEs: DEVERMAN, BENJAMIN E;FENG, GUOPING ;MACOSKO, EVAN Z (contact)

PROJECT_TERMS: adeno-associated viral vector;adenovirus mediated delivery;Animals;arm;Bar Codes;Behavior;Biological Assay;Blood - brain barrier anatomy;Brain;Callithrix;Capsid;cell type;Cells;Central Nervous System;Critical Thinking;density;dentate gyrus;Dopaminergic Cell;dopaminergic neuron;Dorsal;Elements;Engineering;Evaluation;Gene Expression;Gene Expression Profile;Habits;Hippocampus;Human;In Situ;in situ sequencing;In Vitro;in vivo;Individual;Injections;innovation;Location;Maps;Measurement;Measures;Messenger RNA;Methodology;Midbrain structure;Molecular;motor control;Nerve Block;Nervous System;Neuroanatomy;neurogenesis;Neurons;Neurosciences;Pattern;Phenotype;Population;postsynaptic;Preparation;presynaptic;Presynaptic Terminals;Primates;Process;promoter;reconstruction;Resolution;Rewards;RNA;Rodent;Sensitivity and Specificity;Slide;Substantia nigra structure;Synapses;Synaptosomes;System;Technology;Testing;tool;trafficking;transcriptome sequencing;transcriptomics;Validation;Variant;Ventral Striatum;Ventral Tegmental Area;Vertebral column;Work

PROJECT_TITLE: BRAIN CONNECTS: High-Throughput Single Cell Projection Mapping and Spine Quantification in the Primate Brain by Synaptic Barcoding

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-S (17)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Injury;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Public Health Significance: This study will provide critical information about the prevalence, correlates  and consequences of rough sex among AYA, including associations between rough sex and AYA mental and  sexual health. In line with Healthy People 2030, NIH, and CDC goals to prevent traumatic experiences and  decrease mental and sexual health inequities, results will inform meaningful and impactful health programming  aimed at addressing sexual assault, mental health, unintended pregnancy, and STI acquisition among AYA.

PI_NAMEs: HERBENICK, DEBRA LYNNE;NELSON, KIMBERLY M (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: 17 year old;Acute;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Age;Aggressive behavior;Agreement;anxiety symptoms;Birth;Brain Concussion;Categories;Cessation of life;Choking;condoms;Consent;Contraceptive Agents;Contusions;Data;depressive symptoms;Emotional;Ensure;ethnic identity;ethnic minority;Event;expectation;experience;follow-up;Gender Identity;Goals;Health;Health behavior;health inequalities;infection risk;Injury;Interview;Laceration;marginalization;Mental Health;Methods;minority children;Modeling;older women;peer;Persons;Population Surveillance;Pregnancy;pressure;Prevalence;prevent;Public Health;Race;racial minority;racism;recruit;Risk;Sampling;sex;sex assigned;Sex Behavior;Sex Orientation;Sexism;Sexual and Gender Minorities;sexual assault;Sexual Health;sexually active adolescent;Sexually Transmitted Diseases;social;Students;Subgroup;Surveillance Program;Surveys;Survivors;transphobia;trauma symptom;unintended pregnancy;United States;United States National Institutes of Health;university student;Woman;young adult;Youth

PROJECT_TITLE: Sexual health behaviors among US adolescents and young adults

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Caregiving Research;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Among patients being evaluated for heart transplantation or left ventricular assist devices, inadequate duration of caregiving is the most common perceived contraindication to candidacy, and caregiving duration requirements are highly variable across U.S. advanced heart failure centers. This grant proposal uses the PRISM implementation science framework and implementation mapping to conduct critical pre-implementation work that will (1) assess best practices and organizational processes needed to decrease caregiving requirements using a positive deviance approach and (2) adapt interventions that will allow centers to shorten caregiving requirements while simultaneously limiting clinical staff burden and maintaining optimal clinical outcomes. Results of this proposal will inform a future R01 type 1 hybrid effectiveness-implementation trial aimed at: (1) testing non-inferiority of shorter duration caregiving at centers that currently require 3+ months and (2) creating an evidence base defining associations between caregiving and outcomes.

PI_NAMEs: KHAZANIE, PRATEETI  (contact)

PROGRAM_OFFICER_NAME: TATAW-AYUKETAH, GLADYS OROCK

PROJECT_TERMS: Address;Affect;Agreement;Applications Grants;career development;Caregivers;caregiving;Caring;Child Rearing;Clinical;Clinical Research;Consensus;Creativeness;Data;Disease;Educational Status;effectiveness testing;effectiveness/implementation trial;Equity;Evaluation;evidence base;flexibility;Focus Groups;Future;Goals;Health;health care disparity;health difference;Heart;Heart failure;Heart Transplantation;implementation framework;implementation research;implementation science;implementation strategy;implementation study;improved;Inequity;Institutionalization;Intervention;Interview;Knowledge acquisition;left ventricular assist device;Life;Maps;Medical;Methodology;mortality;National Heart, Lung, and Blood Institute;novel;Nurses;Outcome;Participant;Pathway interactions;Patient Selection;Patient-Focused Outcomes;Patients;Policies;Population;Practical Robust Implementation and Sustainability Model;preference;Process;psychosocial;Psychosocial Assessment and Care;Qualitative Methods;Quality of life;Replacement Therapy;Reporting;Research;Resources;social;Social Workers;socioeconomics;Standardization;Structure;Surgeon;Testing;Time;Variant;Vulnerable Populations;Weight;willingness;Work

PROJECT_TITLE: Defining Best Practices to Optimize Caregiving Requirements after Heart Replacement Therapies: A Pre-Implementation Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Z (J2)]


NIH_SPENDING_CATS: Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Computational data analyses have become essential in cancer research, but technical challenges make these data analyses difficult for many cancer researchers. We will develop the Galaxy-C software platform to make it easier for all cancer researchers—especially those with limited informatics expertise—to perform computational data analyses. The Galaxy-C software platform will help cancer researchers perform accurate, robust, and efficient computational data analyses.

PI_NAMEs: GOECKS, JEREMY  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;anti-cancer research;application programming interface;Atlases;Authorization documentation;Categories;Cells;Clinical;Clinical Trials;Cloud Computing;cluster computing;Code;Collaborations;Communities;Computational Science;Computer Analysis;computer infrastructure;Computer software;computing resources;cost effective;Cost Effectiveness Analysis;Data;data access;Data Analyses;Data Commons;Data Science;Data Set;Data Storage and Retrieval;Disease;Ensure;Face;falls;Galaxy;Human;Image;improved;Individual;Informatics;Infrastructure;innovation;Institution;Investments;Machine Learning;machine learning model;Malignant Neoplasms;Minority;molecular imaging;multimodal data;multimodality;natural language;novel;Patient-Focused Outcomes;prevent;Process;Productivity;programs;Registries;Research;Research Personnel;Running;Scientist;Services;skills;Software Tools;Suggestion;Time;tool;tumor;Visualization;web services;Work

PROJECT_TITLE: Developing a Cancer Galaxy Computational Workbench to Meet Emerging Cancer Data Analysis Needs

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-5 (J2)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Esophageal Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative Clear race-based disparities exist with regard to incidence of esophageal cancer in the US; however, the biological underpinnings that support these racial disparities remain unknown. We will utilize single cell RNA Sequencing to assess, for the first time, the influence of race upon cellular and molecular heterogeneity in normal esophageal epithelium as well as epithelium from patients diagnosed with esophageal cancer. These results have profound implications for our understanding of the established disparities in esophageal cancer and help to inform novel approaches that will improve care for all patients with esophageal cancer.

PI_NAMEs: REICHENBACH, ZACHARY W (contact);WHELAN, KELLY A

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Affect;African American;American;ancestry analysis;Basal Cell;Bioinformatics;Biological;Biopsy;Biopsy Specimen;black men;black patient;Black race;Cancer Biology;cancer subtypes;Caring;Caucasians;cell type;Cells;Chemicals;Clinical;Data;Databases;Development;Diagnosis;differential expression;Digestion;Disparity;Distal;DNA Damage;Epithelium;Esophageal Adenocarcinoma;esophageal cancer patient;Esophageal mucous membrane;Esophageal Neoplasms;Esophageal Squamous Cell Carcinoma;Esophageal Tissue;Esophagus;Evaluation;Fishes;Fluorescent in Situ Hybridization;Functional disorder;Gene Combinations;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;genomic data;genomic platform;Genomics;Goals;GSTT2 gene;health disparity;Heterogeneity;Histologic;Human;human subject;improved;In Situ;Incidence;Individual;innovation;Malignant neoplasm of esophagus;Malignant Neoplasms;Maps;men;Molecular;Monitor;mRNA Differential Displays;Mus;Normal tissue morphology;novel strategies;Outcome;Pathology;Pathway interactions;patient population;Patients;Population;Prevention strategy;Proteins;Publishing;Race;racial difference;racial disparity;Research;Resolution;RNA;Sampling;single-cell RNA sequencing;Suspensions;Testing;The Cancer Genome Atlas;Time;Tissues;Transcript;transcriptome sequencing;translational study;tumor;tumor heterogeneity;University Hospitals;Up-Regulation;Validation

PROJECT_TITLE: Contribution of Cellular and Molecular Heterogeneity of Esophageal Epithelium to Health Disparities in Esophageal Cancer

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: In this proposal, we will develop and vet a new type of EM microscope for connectomics with the potential to revolutionize how connectomes are made. This microscope will democratize connectomes, making them cheaper and faster, and enabling full connectomes of mouse brains, and with further optimization, non-human primate, and human connectomes.

PI_NAMEs: BOERGENS, KEVIN MICHAEL;KASTHURI, NARAYANAN  (contact);MASELLI, ANDREW ;WILDENBERG, GREGG

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TITLE: BRAIN CONNECTS: Photoemission Electron Microscopy for Connectomics


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Precision Medicine;Serious Mental Illness

PHR: PROJECT NARRATIVE Despite considerable investments in treatment development for psychological conditions, response rates for most interventions are quite modest (30-40%). Given the limitations of our current psychological intervention system, the overarching goal of the proposed study is to provide initial evidence that targeting a limited number of high-order, personality-based dimensions represents a more potent, parsimonious, and personalized approach to mental healthcare.

PI_NAMEs: SAUER-ZAVALA, SHANNON E (contact);SOUTHWARD, MATTHEW WAYNE

PROJECT_TERMS: Address;Anxiety;Anxiety Disorders;associated symptom;Behavioral;Borderline Personality Disorder;burden of illness;Clinical;clinically significant;comorbidity;Data;data reduction;depressive symptoms;design;Diagnosis;Dimensions;Disease;DSM-V;experimental study;follow-up;Functional disorder;Goals;improved;interest;Intervention;Investments;Mental disorders;Mental Health;Mental Health Services;Modeling;multimodality;National Institute of Mental Health;Needles;Negative Valence;Neurotic Disorders;novel strategies;Participant;Patient Recruitments;Patient Self-Report;Patients;Personality;personalized approach;personalized care;Persons;Phase;Positive Valence;precision medicine;Prevalence;primary outcome;Process;Proliferating;psychologic;Psychopathology;Public Health;Randomized;recruit;reduce symptoms;Research;Research Domain Criteria;Research Personnel;response;Risk;Social Processes;Specific qualifier value;Symptoms;System;Taxonomy;Techniques;Testing;therapy development;Validation;Waiting Lists;Work

PROJECT_TITLE: Engaging Higher-Order Mechanisms of Psychopathology: A Parsimonious Approach to Precision Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (01)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse

ORG_CITY: ALBANY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: Project Narrative  The proposed study will investigate the effects of Uniform Accident and Sickness Policy Provision Law (UPPL) on alcohol consumption and alcohol consumption related outcomes. The results from this study will provide policy makers with new, important information about the effectiveness of UPPLs and contribute to the recent policy discussion on whether these laws should be repealed.

PI_NAMEs: YORUK, BARIS K (contact)

PROGRAM_OFFICER_NAME: PARASURAMAN, SARIKA RANE

PROJECT_TERMS: Accidents;Alcohol abuse;Alcohol consumption;alcohol involvement;alcohol policy information system;Alcohols;Automobile Driving;Behavior;Behavioral Risk Factor Surveillance System;Blood alcohol level measurement;Blood Tests;Cannabis;Code;court;Data;Disincentive;drinking;driving behavior;driving under influence;Drunk driving;Effectiveness;effectiveness evaluation;Emergency department visit;Event;Exhibits;Goals;Health Expenditures;Health Insurance;Healthcare;Heavy Drinking;Impairment;Individual;injured;Injury;Insurance;insurance claims;Insurance Coverage;Intention;interest;Intoxication;Laws;Literature;Methodology;Modeling;Narcotics;Outcome;Patients;Pharmaceutical Preparations;Physicians;Policies;Policy Maker;Probability;Public Policy;Reporting;response;substance use;Surveys;System;Testing;Time;Tobacco;Uninsured Medical Expense;United States National Institutes of Health;Variant;Visit

PROJECT_TITLE: The impact of the Uniform Accident and Sickness Policy Provision Law on Alcohol Consumption and Alcohol Consumption Related Outcomes

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE The neuroimaging community faces numerous challenges in data collection, preprocessing, estimation of brain connectivity, and analyses of relationships between brain connectivity and behavior. An ever-expanding community of researchers are employing optical methods based on functional near infrared spectroscopy and diffuse optical tomography in order to infer pathophysiological state of tissue, such as inflammation and metabolism for detection/characterization of disease or cerebral hemodynamics for understanding human brain health, development, and aging. We propose to broadly disseminate and extend intuitive, validated, powerful cloud-based resources for optical brain mapping that facilitate efficient, accurate, and standardized processing that will harmonize the emerging set of optical measurement strategies within the growing ecosystem of network level analyses used throughout the greater brain mapping community.

PI_NAMEs: EGGEBRECHT, ADAM THOMAS (contact)

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: Address;Adoption;Aging;analysis pipeline;Anatomy;base;Behavior;Brain;brain health;BRAIN initiative;Brain Mapping;cerebral hemodynamics;cloud based;Code;Cognition;Collaborations;Communities;Computer Analysis;Computer software;computerized tools;connectome;cost;crowdsourcing;Data;Data Collection;data resource;Dedications;deep learning;density;Detection;Development;diffuse optical tomography;Disease;Documentation;Ecosystem;Educational workshop;Emotions;Environment;Event;Evolution;Face;flexibility;Frequencies;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Funding;Goals;Health;Health behavior and outcomes;Health Insurance Portability and Accountability Act;Human;Image;improved;Inflammation;Informatics;informatics infrastructure;Infrastructure;Institution;International;Intuition;Libraries;Licensing;Maps;Measurement;Metabolism;Methods;Modeling;Modernization;neural patterning;neuroimaging;new technology;next generation;Online Systems;optical imaging;Optical Methods;Optics;Outcome;Patients;Perception;point of care;precision medicine;Pythons;Recovery;Research;Research Personnel;Resources;Specificity;Standardization;Surface;symposium;Techniques;Technology;technology development;Text;Time;Tissues;tool;Training;usability;wearable device;Writing

PROJECT_TITLE: Open, Extensible, Standardized, and Customizable Computational Tools for Optical Brain Mapping

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-S (16)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Natural Products

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Many of the drugs we use are derived from microbial compounds known as nonribosomal peptides, which are produced by modular assembly-line proteins. While these assembly-lines can evolve in nature and enable microbes to make new drug-like chemicals, we haven’t been able to effectively replicate this process in the lab. In this proposal, we will establish a plug-and-play platform to evolve and engineer modules within assembly- lines, allowing us to program the production of new molecules in living bacteria that could be used as probiotic therapies or producers of new drugs.

PI_NAMEs: JOHNSTON, CHAD WILLIAM (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: adenylate;Amino Acids;Amino Acids Activation;Anti-Bacterial Agents;anti-cancer;anti-fungal agents;Antibiotics;antimicrobial;Bacteria;Bacteriophage M13;Bacteriophages;Binding;Biological;Biological Assay;Bypass;Cells;Chemical Structure;Chemicals;Code;Complement;design;Detection;Directed Molecular Evolution;Drug usage;drug-like compound;Engineering;Enzymatic Biochemistry;enzyme activity;Enzymes;epimerization;Escherichia coli;Evolution;fitness;Gene Expression;gene function;gene product;Generations;Genes;Genetic Code;Genetic Recombination;genetic selection;Immunosuppressive Agents;improved;In Vitro;in vivo;insight;Intervention;Isomerism;Laboratories;Link;Manuals;metabolomics;Methods;Microbe;microbial;Microbial natural product;monomer;Mutation;Natural Products;Nature;novel;novel therapeutics;peptide structure;peptide synthase;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Play;Positioning Attribute;preservation;probiotic therapy;Production;programs;protein aminoacid sequence;protein structure;Proteins;Recording of previous events;Replication-Associated Process;Reporter;Reporting;Research Personnel;Ribosomes;Sampling;Series;Signal Transduction;small molecule;Source;Specific qualifier value;Specificity;Stereoisomer;Structure;Substrate Domain;Substrate Specificity;System;Therapeutic;transcription factor;Translating;Transplantation;Work;Writing

PROJECT_TITLE: A Plug-and-Play Platform for Continuous Directed Evolution of Nonribosomal Peptide Synthetases

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Social Determinants of Health

ORG_CITY: Auburn

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: PROJECT NARRATIVE Sexual minority (SM; e.g., gay, lesbian, bisexual, pansexual, queer, non-heterosexual) individuals are one of the highest-risk groups for developing eating disorders; however, no specific eating disorder treatments for SM individuals exist. Addressing distinct SM identity-related stress processes that maintain eating disorder symptoms in SM individuals could help address this disparity; however, these SM stress processes are not targeted in existing eating disorder treatments. The current study will address this critical gap by refining and testing an innovative virtual treatment that integrates evidence-based care for eating disorders with SM- affirmative care, designed to target mechanisms that underlie increased risk for eating disorders in SM individuals.

PI_NAMEs: BLASHILL, AARON J;BROWN, TIFFANY ASHTON (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: acceptability and feasibility;Address;Adult;barrier to care;biological adaptation to stress;Caring;Chronic;Clinical;coping;Coping Skills;cost;Data;design;Discrimination;Disease remission;disorder risk;Disparity;Dropout;Drops;Eating Disorders;Economic Burden;evidence base;Evidence based treatment;follow up assessment;follow-up;Gender;high risk population;improved;Individual;Inequity;innovation;internalized stigma;Intervention;Investigational Therapies;Lesbian Gay Bisexual;Literature;longitudinal analysis;marginalized population;Mediating;Medical;Mental disorders;minority patient;minority stressor;National Institute of Mental Health;Nature;non-heterosexual;pansexual;Participant;peer;Persons;Phase;physical conditioning;post intervention;Process;promote resilience;psychologic;Public Health;queer;Randomized;Randomized, Controlled Trials;Reaction;Reduce health disparities;Research;Risk;Safety;Self Efficacy;Severities;sexual minority;sexual minority group;sexual minority stress;social;Stress;Stress and Coping;stressor;Symptoms;Techniques;Testing;Time;treatment comparison;trial comparing;United States;Victimization;virtual;virtual delivery;virtual therapy;Vulnerable Populations

PROJECT_TITLE: Targeting Minority Stressors to Improve Eating Disorder Symptoms in Sexual Minority Individuals with Eating Disorders


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Recruiting diverse study samples into clinical trials is imperative to finding solutions to lessen health disparities. This project will evaluate participants’ preferences for specific trial attributes under investigators’ control, which could be leveraged to increase clinical trial participation rates in underrepresented groups. This project will produce generalizable information to help researchers prioritize clinical trial features that are maximally appealing to diverse study participants.

PI_NAMEs: CRANE, MELISSA MARIE (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Affect;Altruism;animation;Area;Bachelor's Degree;Behavior Therapy;Caring;Case Study;Chronic Disease;Chronic Kidney Failure;Clinic;Clinical;Clinical assessments;clinical trial participant;Clinical Trials;Color;Communities;community advisory board;community partners;Conduct Clinical Trials;cost;Data;Decision Making;design;Diabetes Mellitus;Disease;disorder prevention;econometrics;Education;Educational Status;Enrollment;ethnic identity;Ethnic Population;experience;experimental study;Future;Gender Identity;General Population;Generations;Health;health care quality;health disparity;health economics;Home;improved;Incentives;Individual;innovation;Instruction;interest;Intervention;Judgment;Kidney Diseases;Knowledge;Logit Models;low socioeconomic status;Medical;men;Methodology;Mission;Modeling;Motivation;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;Participant;Patient Self-Report;Pattern;Persons;Pharmacology;Population;Population Heterogeneity;preference;Preparation;prevent;Prevention;Prevention trial;programs;racial identity;racial minority population;racial population;Randomized;Recommendation;recruit;Reduce health disparities;Reporting;Research;Research Personnel;Sampling;Sampling Studies;Science;social culture;social group;socioeconomics;Source;Subgroup;Suggestion;Testing;theories;trial design;Trust;Underrepresented Populations;uptake;Variant;Woman;Work

PROJECT_TITLE: Leveraging discrete choice experiments to increase participant diversity in future clinical trials

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Rehabilitation;Social Determinants of Health

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Behavioral interventions at home and school, as well as the communication between home and school, are critical in shaping the mental health outcomes of children with or at-risk for Attention Deficit/Hyperactivity Disorder (ADHD), a prevalent and impairing mental health condition, but caregivers and teachers need implementation supports to use behavioral interventions with fidelity. Using a community participatory approach, we will develop implementation strategies for caregivers to support their use of behavioral interventions as early intervention for children with or at-risk for ADHD, and pilot test them alongside existing teacher-facing Coordinated caregiver-facing and teacher-facing implementation strategies, disseminated through schools, have the potential to promote healthy outcomes for children with ADHD on a large scale.

PI_NAMEs: LAWSON, GWENDOLYN  (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Address;Adult;Attention deficit hyperactivity disorder;Award;Behavior;Behavior Therapy;Behavioral;Caregiver support;Caregivers;Child;Child Mental Health;Collaborations;Communication;community based participatory approach;community engaged approach;community partners;community setting;COVID-19 pandemic;Data;design;Development;Dissemination and Implementation;Early Intervention;Effectiveness;evidence base;Evidence based intervention;Evidence based practice;Family;Feedback;field study;flexibility;Foundations;Functional impairment;Funding;Future;Future Teacher;Goals;health disparity;Home;Hybrids;Impairment;implementation outcomes;implementation strategy;improved;improved outcome;Intervention;Low income;Manuals;Mental Health;Mental Health Services;Methods;minority student;National Institute of Mental Health;Outcome;parenting intervention;Philadelphia;Pilot Projects;pilot test;pilot trial;Planning Theory;Process;psychosocial;Randomized;recruit;Research;Research Personnel;Resources;Risk;Sampling;school district;Schools;Shapes;Structure;success;Symptoms;teacher;Testing;Text Messaging;Training;underserved community;urban school;Work

PROJECT_TITLE: Implementation strategies for caregiver and teacher use of behavioral interventions with ADHD: A pilot study

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Infectious Diseases;Machine Learning and Artificial Intelligence;Pediatric;Rare Diseases

PHR: PROJECT NARRATIVE We propose secondary data analysis of thousands of conjunctival photographs that have been collected and graded for trachoma as part of several previous NIH-funded studies. We will explore the best methods for using conjunctival photography in trachoma monitoring, especially with regards to defining the gold standard photo-grade, aggregating grades from multiple graders, and using more granular trachoma grading systems.

PI_NAMEs: KEENAN, JEREMY DAVID (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: 9 year old;Adoption;aged;Agreement;Algorithms;Antibiotic Therapy;Antibiotics;Applications Grants;Artificial Intelligence;artificial intelligence model;Azithromycin;Blindness;Certification;Child;Chlamydia;Chlamydia trachomatis;Classification;Clinical;Communities;conjunctiva;Consensus;Consumption;Country;Data;Data Analyses;data exploration;Data Set;Decision Making;Eligibility Determination;Ethiopia;Eye;Failure;Foundations;Funding;Grouping;Guidelines;Image;Image Analysis;improved;insight;Label;Left;Methods;Monitor;Pattern;Peru;Photography;population based;Prevalence;Procedures;Process;programs;Public Health;Reading;Recommendation;Reference Standards;Sampling;secondary analysis;Statistical Models;Surveys;Swab;System;Time;Trachoma;Training;United States National Institutes of Health;World Health Organization

PROJECT_TITLE: Developing methods for the use of conjunctival photographs for trachoma monitoring

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (01)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cardiovascular;Genetics;Heart Disease;Human Genome;Immunotherapy

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Myocarditis, a serious inflammatory reaction in the heart causing cardiac death, can occur as a result of immune checkpoint inhibitor therapy. Immune checkpoint inhibitors (ICIs) are a novel class of cancer therapeutics that release the brakes on T-cell cytotoxicity against tumor cells, but may also lead to fulminant myocarditis. This project aims to define a pathway by which macrophages mediate T-cell trafficking to the heart, thus paving the way to prevention and cure of this serious side effect of ICIs and helping ensure cardiovascular safety for cancer patients.

PI_NAMEs: ZHU, HAN  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: adaptive immunity;Adjuvant Therapy;Advanced Malignant Neoplasm;anti-PD-1;Antigens;Arrhythmia;Biology;Blocking Antibodies;Blood;cancer immunotherapy;Cancer Patient;Cardiac;Cardiac Death;Cardiotoxicity;Cardiovascular system;career;Case Fatality Rates;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell motility;Cell Physiology;Cell Separation;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;checkpoint therapy;Clonal Expansion;Coculture Techniques;Collaborations;CXCL10 gene;CXCL9 gene;CXCR3 gene;Cytotoxic T-Lymphocytes;cytotoxicity;Data;design;Development;effective therapy;effector T cell;Ensure;Flow Cytometry;Frequencies;Funding;Goals;Grant;Heart;Heart failure;Heart Injuries;Histology;Immune;Immune checkpoint inhibitor;Immunoglobulin G;Immunology;Immunophenotyping;Immunotherapy;improved;In Vitro;Inflammation;Inflammatory;insight;Knowledge;Laboratories;Life;Ligands;Macrophage;Malignant Neoplasms;Measures;Mediating;migration;Monoclonal Antibodies;mouse model;Mus;Myocardial;Myocarditis;Natural Immunity;neoplastic cell;novel;Pathogenicity;Pathologic;Pathway interactions;pharmacologic;Phase;Phenotype;Play;Precision therapeutics;pressure;prevent;Prevention;programmed cell death ligand 1;programmed cell death protein 1;Reaction;recruit;Regulatory Pathway;Reporting;Role;Safety;side effect;single-cell RNA sequencing;success;System;T cell infiltration;T cell receptor repertoire sequencing;T-Lymphocyte;targeted treatment;Techniques;Testing;Therapeutic;Toxic effect;trafficking;transcriptomics;tumor

PROJECT_TITLE: CXCL9/10 Macrophage Induced CXCR3+ T-cell Recruitment to the Heart Contributes to Immunotherapy Myocarditis


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Palliative Care;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative: With the improvement in cure rates of childhood cancer over the past 50 years to over 80% likelihood of survival, we now have an urgent public health problem that most children survive but endure debilitating symptoms and suffering during treatment. Many children are receiving complementary health interventions such as creative arts without strong evidence of the benefits. This research paves the way for rigorous study of a mind-body intervention with creative arts to improve the whole person health of children with cancer.

PI_NAMEs: RAYBIN, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: acceptability and feasibility;acute symptom;Address;Adherence;Adult;Adverse event;Affect;Age;age group;aged;Anxiety;anxiety reduction;Area;arm;artist;Arts;Attention;behavioral clinical trial;Birth;Brain Neoplasms;cancer care;Cancer Death Rates;cancer therapy;Child;Child Care;Child Welfare;Childhood;Clinical Research;clinical trial implementation;Common Terminology Criteria for Adverse Events;Communication;Complementary Health;Control Groups;conventional therapy;Creativeness;Dancing;Data;Data Analyses;debilitating symptom;design;Development;Diagnosis;Distress;Dose;experience;Face;Focus Groups;Future;Heterogeneity;Hospitals;Hour;improved;innovation;Intervention;intervention refinement;Learning;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Methodological Studies;Methodology;Methods;Mind-Body Intervention;Modality;Monitor;Moods;Movement;multi-site trial;multidisciplinary;Nausea;Nonpharmacologic Therapy;Outcome;Pain;Participant;Patient Outcomes Assessments;Patients;pediatric patients;Phase;Pilot Projects;Procedures;prospective;Protocols documentation;psychosocial;Public Health;Publishing;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;recruit;reduce symptoms;Reporting;Reproducibility;Research;response;Sample Size;Schedule;standard measure;Standardization;Structure;study population;Supportive care;Surveys;Symptom Burden;symptom management;symptom treatment;Symptoms;Testing;Text Messaging;therapy development;Time;Training;treatment arm;two-arm trial;United States;United States National Institutes of Health;volunteer;Vulnerable Populations;whole health;Work

PROJECT_TITLE: CREATe: Clinical Research Examining the Arts as Therapy in children with cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 BH (01)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Natural Products;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE There is an unmet need to identify effective therapies for treating diseases associated with intestinal parasite Giardia lamblia. This organism causes considerable morbidity and mortality, especially among children. A unique set of chemically validated crude fungal extracts will be used to find novel chemical compounds/scaffold that can inhibit the growth of G. lamblia while providing an effective window of safety. Our overall goal is to discover new therapeutic lead compounds and apply them to the needs of people suffering from Giardia infections.

PI_NAMEs: OJO, KAYODE K (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: absorption;Acceleration;Albendazole;antimicrobial;Antiparasitic Agents;benzimidazole;Bioinformatics;Biological;Biological Assay;canine model;Carbohydrates;cell growth;Cell Proliferation;Cells;Cessation of life;Chemicals;Child;citizen science;Clinical;clinical development;Collection;Communicable Diseases;comparative;Complex;Country;Coupled;Cyst;Data;Defect;Detection;Development;Diarrhea;Disease;drug development;drug discovery;drug efficacy;Drug Kinetics;Drug resistance;effective therapy;efficacy study;Engineering;experimental analysis;Fatty acid glycerol esters;FDA approved;fitness;follow-up;Food;Fractionation;Fungal natural products;fungus;Future;Gastrointestinal tract structure;Giardia;Giardia lamblia;Giardiasis;Goals;Grant;Growth;Health Personnel;Human;Impairment;In Vitro;in vivo;in vivo evaluation;indexing;Infection;infection risk;inhibitor;Intestinal parasite;Intestines;Investigation;Investments;Libraries;Link;Luciferases;Malnutrition;Mammalian Cell;meter;Metronidazole;Metronidazole resistance;Morbidity - disease rate;mortality;mouse model;nanoluciferase;natural antimicrobial;Natural Compound;Natural Extract;Natural Products;Natural Products Chemistry;neglect;Neurocognitive;Neurologic;Nitroimidazoles;novel;novel therapeutics;Nutrient;Oklahoma;Oral;Order Coleoptera;Organism;Parasites;Parasitic infection;pathogen;Patients;Penicillins;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Poverty;pre-clinical;preclinical development;Preparation;Prevalence;Process;Program Development;programs;Proliferating;Property;Proteins;Protozoa;Public Health;Reporter;Reproducibility;Research;Resistance;Resource-limited setting;Resources;Risk;Safety;Sampling;scaffold;scale up;screening;Selection Criteria;Small Intestines;success;System;Testing;Therapeutic;therapeutic development;therapeutic lead compound;tool;Toxic effect;Universities;virtual;Washington

PROJECT_TITLE: Discovery of fungus-derived natural products as new and effective Antigiardial agents.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (02)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: OVERALL - NARRATIVE Development of more effective approaches to prevention, diagnosis, care, and therapy of Alzheimer’s disease and related dementias (ADRD) is critically needed in the face of an aging and increasingly diverse population. Advances in the field require targeted, more inclusive team-based research that addresses the needs of understudied populations, as well as complexities related to the heterogeneity of ADRD. The Shiley-Marcos Alzheimer’s Disease Research Center coordinates activities to foster this science, engage the research and broader communities, and educate an emerging and more diverse cadre of brilliant, creative investigators.

PI_NAMEs: BREWER, JAMES B (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Achievement;Address;Affect;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapy;analytical tool;Area;Autopsy;Awareness;bilingualism;Blood Vessels;career;career development;Caregivers;Caring;Cell model;cell type;Clinical;Clinical Trials;Cognitive;cognitive change;cohort;Collaborations;Communities;community engaged approach;community research;Complement;complex data;cost;Country;County;Creativeness;Data;data management;Data Science;Development;Diagnosis;Disease;disorder risk;Diverse Workforce;Early Diagnosis;Education;education research;effective therapy;empowerment;Ensure;Environment;Faculty;Fostering;Functional disorder;Funding;Genetic;Goals;Growth;Heterogeneity;Human;human model;Image;imaging biomarker;improved;Individual;induced pluripotent stem cell;Inflammation;innovation;Institution;interest;Knowledge;Latino;Latino Population;Leadership;Medical Research;member;Mentorship;Metabolism;Methods;Minority;Modeling;Molecular;Nerve Degeneration;neuropathology;next generation;novel diagnostics;novel marker;novel therapeutics;Observation in research;Organoids;outreach;Participant;Pathologic;Pathway interactions;patient engagement;Patients;Performance;phenotypic biomarker;Population;Population Heterogeneity;Positioning Attribute;Prevalence;prevent;Prevention approach;Public Health;Readiness;Recording of previous events;Recovery;recruit;recruitment science;Research;Research Personnel;research study;Resources;responsible research conduct;retention rate;Risk Factors;Role;Science;scientific hub;Scientist;sociocultural determinant;Special Populations Research;statistics;stem cells;success;synergism;Training;translational neuroscience;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Variant;volunteer;Work

PROJECT_TITLE: UCSD Shiley-Marcos Alzheimer's Disease Research Center P30

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Advisory Committees;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Annual Reports;Area;Attention;Award;biomarker identification;Clinical;Collaborations;Communication;Communities;community advisory board;community organizations;community partners;community partnership;Coordination and Collaboration;data exchange;Dementia;Development;Education;Effectiveness;Ensure;Environment;Equilibrium;equity, diversity, and inclusion;Faculty;Feedback;flexibility;Fostering;Funding;Funding Agency;Goals;Grant;Health Personnel;Heterogeneity;Human Resources;Image;innovation;Institution;International;Leadership;Mission;Modeling;Monitor;next generation;operation;outreach;Pathologic;Play;Population Heterogeneity;Problem Solving;Procedures;Process;Productivity;programs;recruit;Research;research and development;Research Institute;Research Personnel;Resource Allocation;Resources;Role;Sampling;Schools;Science;Scientist;Self Management;Study of Latinos;Training;Training Activity;Training Programs;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: GALASKO, DOUGLAS R (contact)

PROJECT_TERMS: Age;Agreement;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Amyloid Proteins;Autopsy;Behavior;bilingualism;Biological Markers;biomarker validation;Blood;blood-based biomarker;Brain;Brain imaging;Brain scan;brain tissue;Cell Line;Cells;Cerebrospinal Fluid;Cessation of life;Classification;Clinical;Clinical assessments;clinical diagnosis;Clinical Research;Clinical Trials;Clinical Trials Unit;Cognition;Cognitive;cognitive ability;cognitive testing;cohort;Collaborations;Collection;Communities;County;Data;data management;Databases;Dedications;Dementia;Dementia with Lewy Bodies;Diagnostic;Disease;DNA;DNA analysis;Down's Syndrome;Early Diagnosis;Education;Elements;Enrollment;Ensure;Equilibrium;Ethnic Population;Evaluation;Faculty;Family;follow-up;frontotemporal degeneration;Frontotemporal Dementia;Funding;Genetic;Goals;Heterogeneity;human old age (65+);Image;imaging biomarker;improved;induced pluripotent stem cell;innovation;interest;Laboratories;Latino;Latino Population;Liquid substance;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Medical;meetings;member;Memory;Methods;microbiome;mild cognitive impairment;mixed dementia;Modeling;Monitor;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurologic Examination;neuropathology;Neuropsychological Tests;novel;novel marker;older adult;Oranges;Participant;Pathologic;Pathology;Patient Recruitments;Persons;Pharmaceutical Preparations;Phenotype;Plasma;Positron-Emission Tomography;Procedures;Process;programs;protective factors;Protocols documentation;Quality Control;Recording of previous events;recruit;Registries;repository;Research;Research Personnel;Research Project Grants;Research Support;response;Risk Factors;Saliva;Sampling;sex;single-cell RNA sequencing;skin biopsy;social health determinants;Spinal Puncture;Symptoms;tau Proteins;Testing;Therapeutic antibodies;Time;Training Support;Translational Research;Underrepresented Populations;United States National Institutes of Health;Update;Vascular Cognitive Impairment;volunteer

PROJECT_TITLE: Core B: Clinical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PI_NAMEs: EDLAND, STEVEN DYAL (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Biological Markers;biomarker identification;Biometry;Clinical;clinical center;Clinical Data;Clinical Trials;Cohort Studies;Complex;Consultations;dashboard;Data;data access;Data Analyses;Data Coordinating Center;data management;data sharing;Database Management Systems;Databases;design;Enrollment;Ensure;Evaluation;Event;Faculty;faculty mentor;follow-up;Goals;graduate student;Heterogeneity;Human Resources;Image;induced pluripotent stem cell;Information Systems;Infrastructure;Latino;Longitudinal cohort;Longitudinal cohort study;longitudinal database;Manuscripts;Mentors;Methodology;Modeling;Monitor;neuropathology;Online Systems;operation;Outcome;Outpatients;outreach;Participant;patient engagement;Peer Review;Postdoctoral Fellow;Preparation;Procedures;Process;Production;Publications;Quality Control;query tools;R programming language;recruit;Recruitment Activity;Registries;relational database;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Support;Resources;Retrieval;Schedule;Secure;Services;Statistical Data Interpretation;statistics;success;Tissues;transmission process;volunteer;web-based tool

PROJECT_TITLE: Core C: Data Management and Statistical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: ROY, SUBHOJIT  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;age related;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;Autopsy;biobank;Biological Assay;Brain;brain tissue;California;case control;cell type;Cessation of life;Clinical;cohort;Collaborations;Collection;COVID-19 pandemic;Data;Dementia;Development;Diagnosis;Diagnostic;digital pathology;Disease;Dura Mater;Early Diagnosis;Ensure;epigenomics;Equipment and supply inventories;Evaluation;Eye;Faculty;Fostering;Freezing;Frontotemporal Lobar Degenerations;Future;Goals;Guidelines;Heterogeneity;Induced Neurons;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;innovation;Institution;interest;International;Latino;Latino Population;Lewy Body Dementia;limbic-predominant age-related TDP-43 encephalopathy;Mentors;Methodology;Methods;Mission;Modeling;Molecular;multiple omics;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;Nervous System;neuroAIDS;Neuroanatomy;Neurodegenerative Disorders;Neurons;neuropathology;Neuropsychology;next generation;novel;novel diagnostics;Participant;participant enrollment;Pathologic;Pathology;Patients;Population;Population Heterogeneity;prion-like;Procedures;protein TDP-43;Proteins;Research;research and development;Research Personnel;Research Support;Resources;Sampling;Scientist;Series;shared database;Site;Skin;Specimen;Stains;Standardization;Students;symposium;synergism;System;tau Proteins;Tauopathies;Tissue Banks;Tissues;Training;training opportunity;transcriptomics;Work;working group

PROJECT_TITLE: Core D: Neuropathology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: PEAVY, GUERRY MARIE (contact)

PROJECT_TERMS: Acute;Address;Affect;African American;Alaskan;Alzheimer's Disease;Alzheimer's disease related dementia;American Indians;Asian;Asian Americans;Attitude;Autopsy;base;bilingualism;career;Caring;Catchment Area;Censuses;Classification;Clinic;Clinical;Clinical Trials;Communities;community advisory board;Community Healthcare;community organizations;Community Outreach;community partners;County;Data;Disease;disease heterogeneity;diversity and inclusion;Education;Education and Outreach;Educational Activities;Educational Materials;Educational Status;effective therapy;Enrollment;Ensure;Equity;Ethnic Origin;Event;experience;Family;Generations;Goals;health care availability;Health Personnel;Health Professional;Hispanic;human old age (65+);Immigrant;improved;Individual;Information Dissemination;interest;Language;Latino;Latino Population;literacy;Longitudinal Studies;Masks;member;Memory;Mentors;Methods;Neurology;neuropathology;Neurosciences;Newsletter;next generation;Not Hispanic or Latino;Observational Study;outreach;outreach program;Pacific Islander;Participant;Patients;Persons;Population;preference;Procedures;Professional Education;programs;Quality of life;recruit;recruitment science;Registries;Reporting;Research;Resources;retention rate;screening;service organization;Services;social media;Social Work;socioeconomics;Source;Spanish;Spanish/English;student participation;Students;success;Support Groups;Target Populations;therapy development;Underrepresented Populations;volunteer;web site;Work

PROJECT_TITLE: Core E: Outreach, Recruitment and Engagement Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

PROJECT_TERMS: accurate diagnosis;Age;Aging;aging clocks;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Applications Grants;Arteriosclerosis;Basic Science;Behavior;biobank;Biological;Biological Assay;Biological Markers;Biotechnology;Blood;Blood Vessels;Brain;brain magnetic resonance imaging;Budgets;Catalogs;Cell Line;Cells;Cerebrospinal Fluid;Clinical;clinical phenotype;Cognitive;cohort;Collaborations;Communities;Consultations;Data;Data Analyses;data sharing;Diagnosis;Differential Diagnosis;Disease;disease heterogeneity;DNA;DNA Methylation;Early Diagnosis;Education;Educational process of instructing;Ensure;Epigenetic Process;Equipment and Supplies;Ethnic Origin;Faculty;follow-up;Functional disorder;Funding;Genetic;genetic analysis;genome wide association study;Genotype;glymphatic function;hazard;Heterogeneity;Histology;Image;imaging study;induced pluripotent stem cell;Industry;Interest Group;International;Laboratories;Latino;Latino Population;Lead;Leadership;lipidomics;Liquid substance;Magnetic Resonance Imaging;Maps;Measures;Metabolism;Methods;microbiome;Monitor;Motor;myelination;Nerve Degeneration;neuroimaging;neuroinflammation;neuropathology;novel;novel marker;online resource;operation;Other Genetics;Participant;Pathologic;Pathology;Phenotype;Plasma;Positron-Emission Tomography;pre-clinical;precision medicine;Process;Prognosis;Protein Analysis;protein TDP-43;Proteomics;Quality Control;repository;Research;Research Activity;Research Personnel;Research Support;Resources;Review Committee;RNA analysis;Sampling;Serum;sex;social health determinants;Staging;Standardization;Structure;Synapses;tau Proteins;Tissues;Validation;Vascular Cognitive Impairment;Vascular Diseases;Work;β-amyloid burden

PROJECT_TITLE: Core F: Biomarker Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: BONDI, MARK W (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Award;Biological;Biological Markers;Biometry;career development;Career Mobility;Clinical;Clinical Sciences;Collaborations;Communication;Communities;Complex;Data;Development;disability;Discipline;Distal;Education;education research;Educational Curriculum;Effectiveness;effectiveness evaluation;Engineering;Ethics;Ethnic Origin;Etiology;experience;Faculty;Feedback;Fostering;Foundations;Funding;Genetic;Geriatrics;Goals;Grant;Heterogeneity;improved;Informed Consent;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Knowledge;Lead;Measures;medical schools;Medicine;meetings;member;Mentors;Mentorship;Modeling;Monitor;multidisciplinary;Nature;Neuropsychology;Neurosciences;novel;Outcome;Participant;Pharmacologic Substance;Pharmacology;post-doctoral training;Postdoctoral Fellow;Prevalence;prevent;professor;programs;Progress Reports;Psychiatry;Psychology;Publications;Publishing;Race;recruit;Research;research and development;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;responsible research conduct;Risk Factors;Science;Scientist;Site;skills;Solid;Special Population;STEM research;Structure;Study Section;Suggestion;supportive environment;Surveys;Technology;Training;Training Activity;Training and Education;Training Programs;Translational Research;Underrepresented Populations;Work;Writing

PROJECT_TITLE: Core G: Research Education Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: GOLLAN, TAMAR  (contact)

PROJECT_TERMS: accurate diagnosis;Address;African American population;age related;Aging;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Attitude;Autopsy;Awareness;base;Behavioral;bilingualism;Biological;Biological Markers;Biostatistics Core;Birth;Blood;Brain;brain health;burden of illness;California;Cardiovascular system;care burden;Caring;caucasian American;Characteristics;Clinic;Clinical;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive testing;cohort;Communities;County;Data;data management;data sharing;Dementia;Development;Diagnosis;Disease;disparity reduction;Early treatment;Education;education research;Effectiveness;Elderly;Enrollment;Ensure;Environment;Evaluation;Exposure to;Genetic;health disparity;Healthcare;Impaired cognition;improved;induced pluripotent stem cell;innovation;insight;Insurance;interest;Intervention;Investigation;Judgment;Knowledge;Language;Latino;Latino Population;Life Expectancy;lifetime risk;Linguistics;Memory;Metabolic;Methods;Multilingualism;Names;Neurocognitive;neuroimaging;Neurologic;neuropathology;Neuropsychological Tests;Neuropsychology;outreach;Patient Self-Report;Patients;Persons;Physicians;Population;Positioning Attribute;pre-clinical;Procedures;recruit;Registries;Reporting;Research;Risk;Risk Factors;Role;Sampling;screening;Services;social culture;Spanish;Spanish/English;Specimen;Spinal Puncture;Study of Latinos;Testing;tool;Trust;vascular cognitive impairment and dementia;volunteer;willingness;Work

PROJECT_TITLE: Core H: Latino Core