ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Community-based interventions to improve psychosocial wellbeing and reduce sedentary behavior among insufficiently active Black adults are lacking. This study will be the first to establish the feasibility and acceptability of a culturally adapted, light-intensity yoga intervention to improve psychosocial wellbeing, reduce sedentary behavior, and promote movement among insufficiently active Black adults and to demonstrate whether the intervention can be delivered with fidelity across two geographically distinct sites, a large urban city and a more rural, medically underserved nonmetropolitan area. If the efficacy of this yoga-based intervention is confirmed in a larger, multi-site efficacy trial, it could offer an attractive, scalable community- and faith-based intervention to improve psychosocial wellbeing and physical activity in low active Black adults and reduce health disparities.

PI_NAMEs: MAMA, SCHEREZADE KELLY (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: acceptability and feasibility;Adherence;Adoption;Adult;American;attentional control;Awareness;biopsychosocial;Black race;Blinded;Breathing;Cardiovascular Diseases;cardiovascular disorder risk;Chronic Disease;Church;Cities;Communities;community intervention;community partners;Control Groups;design;Discrimination;disorder prevention;disorder risk;Educational Curriculum;efficacy testing;efficacy trial;ethnic health disparity;experience;Faith;faith-based intervention;Feasibility Studies;feasibility testing;follow-up;Future;Geography;Goals;Health;Health behavior and outcomes;Health Benefit;Hour;implementation protocol;improve minority health;improved;Individual;innovation;Intervention;Interview;Leadership;lifestyle intervention;light intensity;Malignant Neoplasms;Manuals;Measures;medically underserved;meetings;Metabolic;Mind;Mind-Body Intervention;mindfulness;Modeling;moderate-to-vigorous physical activity;Morbidity - disease rate;mortality;Movement;multi-site trial;multiple chronic conditions;National Center for Complementary and Integrative Health;nonmetropolitan area;Not Hispanic or Latino;novel;novel strategies;pandemic disease;Participant;Persons;Phase;Physical activity;physical inactivity;Pilot Projects;Play;post intervention;Preparation;Procedures;programs;Protocols documentation;psychosocial wellbeing;racial health disparity;racism;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reduce health disparities;Relaxation;Relaxation Techniques;Role;Role playing therapy;Rural;rural area;rural health disparities;Sampling;satisfaction;sedentary;sedentary lifestyle;Site;social cognitive theory;Spirituality;Standardization;strength training;Stress;stressor;Stretching;success;Testing;Texas;Time;tool;Training;uptake;urban area;Walking;Well in self;Work;Yoga

PROJECT_TITLE: Multi-site feasibility and acceptability of a faith-based mind-body intervention in Black adults


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Hematology;Rare Diseases

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The goal of this study is to optimize and validate a series of 3D Ultrashort Echo Time (UTE) MRI sequences with TEs ~100 times shorter than those of clinical sequences for comprehensive evaluation of joints with hemophilic arthropathy (HA) through assessment of hemosiderin, cartilage, and the osteochondral junction. We will first optimize a series of UTE MRI techniques in phantoms and human patellar samples, then validate them in ex vivo tissues from hemophilia patients following total knee arthroplasty (n=10) and from normal cadaveric human knee joints (n=10). Finally, we will apply the optimized 3D UTE and clinical MRI techniques in three groups of hemophilia patients with mild (n=20), moderate (n=20), and severe (n=20) HA at two time points (baseline and 12 months) and in one group of age-matched healthy volunteers (n=20) once, to evaluate the outcomes of prophylaxis by correlating cross-sectional and longitudinal UTE and clinical MRI measures with Hemophilia Joint Health Scores (HJHSs), Pettersson radiograph scores, and other self-reported outcomes.

PI_NAMEs: JANG, HYUNGSEOK  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Achievement;Age;age group;Area;articular cartilage;Biochemistry;Biological Markers;Biomechanics;Blood Coagulation Disorders;Blood Coagulation Factor;Cadaver;Cartilage;Clinical;Collagen;contrast imaging;Control Groups;cost;Cyst;Data;density;Deposition;Deterioration;Diagnosis;Disabling;Disease Management;Disease Progression;Early Diagnosis;Etiology;Evaluation;Factor IX;Factor VIII;Fatty acid glycerol esters;Goals;Health;healthy volunteer;Hemophilia A;Hemophilic Arthritis;Hemorrhage;Hemosiderin;Histopathology;Human;Image;Imaging Techniques;in vivo;Iron;joint destruction;Joints;Knee joint;knee replacement arthroplasty;Lesion;Ligaments;Link;Longitudinal Studies;Magic;Magnetic Resonance Imaging;Magnetism;Maps;Measures;Meniscus structure of joint;Modeling;Monitor;Morphology;non-invasive imaging;Normal tissue morphology;osteochondral tissue;Outcome;Patient Self-Report;Patients;precision medicine;Predisposition;prevent;prophylactic;Prophylactic treatment;Proteoglycan;Quantitative Evaluations;Recovery;Recurrence;Relaxation;Resolution;Sampling;Scanning;Series;Signal Transduction;Speed;subchondral bone;Synovial Membrane;Synovitis;Techniques;Tendon structure;Time;Tissues;Treatment Cost;treatment planning;ultrasound;validation studies

PROJECT_TITLE: Ultrashort Echo Time Magnetic Resonance Imaging of Hemophilic Arthropathy

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: BETHLEHEM

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: LEHIGH UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project aims to develop a novel antibiotic delivery vehicle to enable the controlled delivery of antibiotics to treat aggressive periodontal infections in adolescents. Current treatment options are often ineffective, necessitating multiple treatments to clear the infection. The outcome of this work will be a novel non-surgical therapeutic to enhance current treatment options.

PI_NAMEs: BROWN, ANGELA C. (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Actinobacillus actinomycetemcomitans;Adolescent;adolescent patient;Adsorption;adverse drug reaction;Affect;Affinity;Antibiotic Resistance;Antibiotics;Automobile Driving;Bacteria;Binding;biophysical analysis;Cell membrane;Cell Survival;Cells;Cholesterol;Clinical;Clinical Treatment;Coculture Techniques;common treatment;delivery vehicle;Development;Disease;Disease Progression;Encapsulated;Engineering;Equus caballus;Future;Goals;Gram-Negative Bacteria;host colonization;Immune;improved;Infection;innovation;Left;leukotoxin;Lipids;liposomal delivery;Liposomes;Mediating;Membrane;Membrane Lipids;Mission;Modality;Modeling;nanomolar;National Institute of Dental and Craniofacial Research;novel;novel therapeutics;Oral health;Outcome;Pathogenesis;Pathogenicity;Patients;Periodontal Infection;Periodontitis;Phase;phase change;Plasma Cells;Porifera;Proteins;Recommendation;Research;Role;scaling and root planing;System;Testing;Therapeutic;therapeutic target;Toxin;treatment strategy;Virulence Factors;Work

PROJECT_TITLE: Controlled antibiotic delivery vehicle for treatment of aggressiveperiodontitis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Cerebrovascular;Childhood Injury;Intellectual and Developmental Disabilities (IDD);Maternal Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Stroke;Unintentional Childhood Injury;Women's Health Research

ORG_CITY: DETROIT

ORG_DEPT: PEDIATRICS

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE  There is a paucity of effective treatments for cerebral palsy and this proposal tests new promising drugs aimed at a preventive cure for this disease. These are new drugs aimed at inhibiting an enzyme present in brain called neuronal nitric oxide synthase. New information about how these drugs act, how they affect brain cells, and how effective they are in an animal model of cerebral palsy will be very valuable for future translation to clinical use in humans throughout the world.

PI_NAMEs: TAN, SIDHARTHA  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Abbreviations;Abruptio Placentae;Acute;Adult;Affect;Animal Model;antenatal;Antioxidants;Area;Axon;Biochemical;Birth;Brain;brain cell;Brain Hypoxia-Ischemia;Brain Injuries;Brain region;burden of illness;Cell Culture Techniques;cell injury;Cell Physiology;Cerebral Palsy;Childhood;Cholera Toxin;Clinical;Clinical Trials;Communities;cost;Country;Dancing;Developed Countries;Development;Diffusion;Disease;Dose;drug action;drug candidate;effective therapy;Electron Spin Resonance Spectroscopy;Electrophysiology (science);Endoplasmic Reticulum;Endothelium;Enzyme Inhibition;Equation;Ethidium;Facilities and Administrative Costs;Family;fetal;Fetal Distress;Fetus;Fiber;Financial cost;Free Radicals;Future;Generations;Genetic;gray matter;High Pressure Liquid Chromatography;Human;hydroethidine;in vivo;indexing;inhibitor;Injury;innovation;interest;Laboratories;Location;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Methodology;Modeling;Molecular;Morbidity - disease rate;mortality;Mothers;Motor;motor deficit;Motor disability;Muscle Hypertonia;Nature;neonatal hypoxic-ischemic brain injury;Nervous System Disorder;Neuronal Injury;Neurons;neuroprotection;Neuroprotective Agents;Nitric Oxide;Nitric Oxide Synthase Type I;Nitric Oxide Synthetase Inhibitor;Nitrogen Oxides;nitrosative stress;novel;novel therapeutics;Oryctolagus cuniculus;Outcome;Oxidants;oxidation;Oxidation-Reduction;Oxidative Stress;Parents;Pathway interactions;Patients;Perinatal;Perinatal Hypoxia;perinatal period;Pharmaceutical Preparations;Phase;Phenotype;Placental Insufficiency;postnatal;Pregnancy;Premature Labor;Prevalence;prevent;Prevention;Prevention therapy;Preventive;Property;Propidium Diiodide;Reactive Nitrogen Species;Reactive Oxygen Species;Reperfusion Therapy;Resource-limited setting;Resources;response;Rhodamine 123;Rodent Model;severe injury;Siblings;Societies;Sorting;Specificity;Speed;Stress;Sum;Superoxide Dismutase;Superoxides;Surrogate Markers;System;Techniques;Testing;Therapeutic;Time;Tissues;Translating;Translations;Western Blotting;white matter;white matter injury

PROJECT_TITLE: Neuroprotection by nNOS inhibitors in perinatal hypoxia-ischemia

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: WILMINGTON

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, DELAWARE

ORG_STATE: DE

PHR: Project Narrative Public Health Relevance In comparison to many other childhood cancers, the prognosis of pediatric brain cancers remains poor. Targeting pathways that relate information from the tumor microenvironment and serve as intracellular regulatory hubs presents new opportunities for developing innovative therapeutic approaches, including in pediatric brain tumors. The proposed research will develop a tunable three-dimensional cell culture platform that is compatible with automated high- throughput screening for targeting an oncogenic signaling pathway that serves as a central integrator of information from the tumor microenvironment.

PI_NAMEs: LANGHANS, SIGRID A (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: 3-Dimensional;Adherent Culture;Adhesions;Adhesives;Affect;Antineoplastic Agents;Area;Biological Assay;Biological Process;Biology;biomarker discovery;biomaterial compatibility;Brain;Brain Neoplasms;cancer cell;Cell Culture Techniques;Cell Differentiation process;cell dimension;cell motility;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cerebellum;Childhood Brain Neoplasm;Childhood Malignant Brain Tumor;Clinical Trials;Collagen;Combined Modality Therapy;Cues;Data;design;Development;drug development;drug discovery;Drug Screening;Drug Targeting;effective therapy;efficacy testing;Encapsulated;Environment;Equipment;experience;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;FDA approved;Foundations;Future;Growth Factor;healing;High Prevalence;high standard;high throughput screening;Human;hydrogel scaffold;Hydrogels;improved;in vivo;Injectable;innovation;interest;Laboratories;Libraries;Liquid substance;Luciferases;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Matrix Metalloproteinases;Measures;mechanical properties;Mediator;Medulloblastoma;methylome;Modeling;monolayer;mortality;mouse model;Mus;Natural Products;neoplastic cell;Neurons;new technology;new therapeutic target;Oncogenic;Outcome Study;Pathway interactions;Peptides;Performance;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiology;Polysaccharides;precision medicine;Prognosis;Property;Proteins;Proteoglycan;public health relevance;Quality Control;Research;Robotics;scaffold;screening;Second Primary Cancers;self assembly;sensor;side effect;Signal Pathway;Signal Transduction;Solid;success;Survivors;Technology;Testing;Therapeutic;Thinness;three dimensional cell culture;Time;Tissues;Transcriptional Coactivator with PDZ-Binding Motif;Transgenic Organisms;tumor;tumor microenvironment;two-dimensional;Vertebral column;Work

PROJECT_TITLE: Targeting mechanosignaling in pediatric brain cancer

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Every day, humans and other animals make decisions based on our preferences. This project will investigate how the lateral habenula and dorsal raphe nucleus, both implicated in disorders such as depression and anxiety, are involved in these decisions, which are an indispensable part of our lives and a key determinant of mental health. Understanding the role of these structures in subjective decision-making will lay the groundwork for future investigations of the behavioral and neural systems that underlie depression, anxiety, and related disorders, and open the door to new therapeutic avenues.

PI_NAMEs: FENG, YAN-YANG  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Adaptive Behaviors;Address;Animal Model;Animals;anti-depressive agents;Anxiety;anxiety-like behavior;Basal Ganglia;Behavioral;Brain;Cell Nucleus;Choice Behavior;Complex;Data;Decision Making;depressive symptoms;design;discount;Disease;Dorsal;dorsal raphe nucleus;Electric Stimulation;Evaluation;experimental study;Future;GABA Agonists;Globus Pallidus;Habenula;Human;Individual;Injections;insight;Investigation;Lateral;Mediating;Mental Depression;Mental Health;Monkeys;Morbidity - disease rate;neural;Neuromodulator;Neurons;neurotransmission;news;novel therapeutics;optogenetics;Outcome;Output;Pharmacologic Substance;Play;preference;Primates;Procedures;Process;Psychiatrist;Psychopathology;raphe nuclei;Research;response;Rewards;Risk;Role;Serotonin;Signal Transduction;skill acquisition;Source;Specificity;Structure;System;Testing;Therapeutic Effect;Time;Training;Work

PROJECT_TITLE: Determining the role of the primate raphe-habenula circuit in multi-attribute decision-making


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Personalized cancer therapy represents one of the promising strategy of cancer treatment, however, the success rate is still limited to only a fraction of the patients. The purpose of this project is to examine novel mechanisms of cancer progression with a specific focus on how genomic copy number alterations and to study the Achilles’ heel of cancer cells associated with the presence of these genomic events. Because these alterations are very frequent in cancer but absent from normal tissues, these efforts have the potential to identify novel therapeutic targets to improve cancer patients’ outcome.

PI_NAMEs: DAVOLI, TERESA  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Adopted;Affect;Aneuploid Cells;Aneuploidy;Biological Markers;cancer cell;Cancer cell line;Cancer Patient;cancer therapy;Candidate Disease Gene;candidate validation;Cell Death;Cell Line;Cell model;cell type;Cells;Cellular Stress;Centromere;Chromosome 7;chromosome 7 gain;Chromosomes;Clinical;Clinical Research;cohort;Colon;colon cancer cell line;Colorectal Adenocarcinoma;Colorectal Cancer;Colorectal Neoplasms;CRISPR screen;Data;Diploid Cells;Disease;dosage;Engineering;Event;experimental study;Foundations;FRAP1 gene;Frequencies;Genes;Genetic;Genetic Transcription;Genomics;Goals;Human;Human Chromosomes;improved;In Vitro;in vivo;Knowledge;Malignant Neoplasms;Methods;Molecular;mouse model;neoplastic cell;new therapeutic target;Normal tissue morphology;novel;Oncogenic;Operative Surgical Procedures;Organoids;Outcome;overexpression;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;personalized cancer therapy;Phenotype;Phosphoproteins;Proliferating;Property;Protein Inhibition;Protein Synthesis Inhibition;Proteins;Proteomics;Regulation;Role;Sampling;Signal Transduction;Solid Neoplasm;success;synthetic lethal interaction;System;Testing;therapeutic target;therapy resistant;Translations;tumor;tumor progression;tumorigenesis

PROJECT_TITLE: Deconstructing and targeting aneuploidy in human cancer  - Resubmission - 1

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Diabetes;Endocrine Disruptors;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pregnancy;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: This project will examine maternal phthalate exposure across pregnancy and the postpartum to determine the extent to which these metabolic disrupting chemicals may influence body weight/composition changes and cardiometabolic health during the first four years after childbirth. Newer statistical modeling approaches will be used to identify sensitive windows of exposure during which phthalates most impact maternal cardiometabolic health. The results of this project will provide important knowledge about how metabolic disrupting chemicals during pregnancy and the early postpartum impact cardiometabolic trajectories, with long-term implications for women’s health.

PI_NAMEs: BARRETT, EMILY S;GROTH, SUSAN W;JAMES-TODD, TAMARRA M (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: arterial stiffness;Biological Markers;Biological Specimen Banks;Birth;Blood Vessels;Body Composition;Body System;Body Weight;C-reactive protein;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Chemicals;Childbirth;Chronic Disease;cohort;Cohort Studies;Collection;Coupled;critical period;Data;data repository;design;Diabetes Mellitus;Diastolic blood pressure;Dibutyl Phthalate;early pregnancy;Eligibility Determination;Endocrine;Endocrine disruption;environmental chemical;Exposure to;Failure;Fetus;First Pregnancy Trimester;follow-up;Future;Gestational Diabetes;gestational weight gain;Health;Hormones;Hypertension;Immune;immune function;impaired glucose tolerance;improved;Individual;Inflammatory;Infrastructure;insight;interest;Knowledge;Late pregnancy;Link;Maternal Health;maternal obesity;Maternal Physiology;Measures;Mediating;Metabolic;Metabolic syndrome;Metabolism;Modeling;Mothers;Multiple Pregnancy;Non-Insulin-Dependent Diabetes Mellitus;Nuclear Receptors;Obesity;Outcome;Pathway interactions;phthalates;Physiological;Postpartum Period;Pregnancy;pregnancy hypertension;prenatal;recruit;Research;Risk;Sample Size;Statistical Models;Sum;Third Pregnancy Trimester;Time;urinary;waist circumference;Weight;Weight Gain;Woman;Women's Health

PROJECT_TITLE: Pregnancy and postpartum as vulnerable exposure windows: phthalates and maternal cardiometabolic health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE Medulloblastoma (MB) is the most common pediatric malignant brain tumor and has a global impact on children's overall health. Chimeric antigen receptor (CAR) T cell immunotherapy has the potential to improve outcomes in patients with MB; however, CAR T cells efficacy for brain tumors have been limited this far. In this study, we propose to overcome current CAR T cell limitations and enhance CAR T cell efficacy for MB by establishing CAR T cells targeting two brain tumor antigens, silencing negative T cell regulators, and targeting suppressive effectors of the brain tumor microenvironment including tumor associated macrophages.

PI_NAMEs: KRENCIUTE, GIEDRE  (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Ablation;Address;Affect;angiogenesis;antigen challenge;antigen-specific T cells;Antigens;antitumor effect;Antitumor Response;B lymphoid malignancy;Brain Neoplasms;cancer cell;cancer therapy;Cancerous;CD276 gene;Cell Communication;Cell Physiology;Cell Therapy;Cells;Child;Childhood Brain Neoplasm;Childhood Malignant Brain Tumor;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Research;Combined Modality Therapy;conventional therapy;CSF1R gene;cytokine;Dioxygenases;DNA;DNA Modification Methylases;effector T cell;Endowment;Engineered Gene;engineered T cells;Engineering;Epigenetic Process;ERBB2 gene;exhaustion;experience;experimental study;Frequencies;Future;Genetic;Health;IL13RA1 gene;Immune;Immune response;Immune system;Immunocompetent;immunoengineering;Immunotherapy;improved;improved outcome;Infusion procedures;inhibitor;Innovative Therapy;insight;Institution;Knowledge;Lead;Left;leukemia;Macrophage Colony-Stimulating Factor;Malignant Neoplasms;Mediating;Mediator;Medulloblastoma;Methods;Methyltransferase;Modification;Molecular;mouse model;Mus;Neoplasm Metastasis;novel therapeutic intervention;Patients;Performance;Phase I Clinical Trials;pre-clinical;Pre-Clinical Model;preclinical study;Production;programs;receptor;recruit;Recurrence;Recurrent tumor;Relapse;Resistance;Resources;safety engineering;side effect;Signal Transduction;Specificity;success;synergism;T-Cell Immunologic Specificity;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Tetanus Helper Peptide;Text;Therapeutic;Tissues;tool;tumor;Tumor Antigens;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;tumor-immune system interactions;Xenograft procedure

PROJECT_TITLE: Improving genetically engineered T cells for medulloblastomas

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Narrative Regulation of transcription by transcription factors and coactivators is a key mechanism for control of cell growth, differentiation, and development. Defects in transcriptional regulation directly contribute to many human illnesses. Our proposed work will identify conserved fundamental regulatory mechanisms and gene-specific functions of transcription factors and coactivators that explain how diverse transcription factors cooperate to precisely modulate gene expression.

PI_NAMEs: HAHN, STEVEN M (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Area;Binding;Biochemical;cell growth;Cell Physiology;Chromatin;Complex;Defect;Development;Gene Expression;Gene Expression Regulation;Genes;Genetic Enhancer Element;Genetic Transcription;genome-wide;Genomics;Human;human disease;Link;Mediator;Methods;Molecular;new technology;novel strategies;Pathway interactions;promoter;response;SAGA;Specificity;TAF1 gene;Technology;Time;Transcription Coactivator;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: Mechanisms of transcriptional regulation and transcription factor specificity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-X(07)R]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Type 2 diabetes (T2D) is caused by the inability to regulate blood glucose levels due to decreased islet β cell function or mass and has been attributed to loss of β-cell identity or de-differentiation. While the etiology of β- cell immaturity in T2D is unclear, impairments in nuclear-encoded mitochondrial gene expression and transcription factor expression occur. These studies will investigate how the transcription factors MAFA and MAFB and mitochondrial health control human β-cell identity and function to maintain β-cell maturity and proper insulin secretion.

PI_NAMEs: WALKER, EMILY M (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Adult;Affect;B-Lymphocytes;Back;Beta Cell;Biogenesis;biological adaptation to stress;Biological Assay;Blood Glucose;blood glucose regulation;cell dedifferentiation;Cell Differentiation process;Cell Line;Cell Maturation;Cell Physiology;Cells;Complement Factor B;Consumption;Data;Defect;Diabetes Mellitus;Equilibrium;Etiology;factor A;Failure;Feedback;Functional disorder;functional restoration;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Expression Regulation;Gene Targeting;Genes;Genetic;Genetic Transcription;Glucose;Health;Homo;Human;human embryonic stem cell;humoral immunity deficiency;Impairment;in vivo;Insulin;insulin secretion;islet;knock-down;Life Cycle Stages;maturity onset diabetes of the young;Metabolic;Metabolic Control;metabolomics;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mus;Non-Insulin-Dependent Diabetes Mellitus;Nuclear;oxidative damage;Oxidative Stress;Oxygen Consumption;Pathway interactions;Patients;pharmacologic;Phosphotransferases;Physiological;programs;Proteins;Regulation;Reporting;response;Role;Signal Transduction;single-cell RNA sequencing;stem cell biomarkers;Structure;targeted treatment;Testing;tool;transcription factor;Transplantation

PROJECT_TITLE: Elucidating how transcription factors MAFA and MAFB and mitochondrial activity control human Î² cell identity and function

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: LEGON

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: UNIVERSITY OF GHANA

PHR: Project Narrative The proposed program will have significant, long-term impact on health research in Ghana and the West Africa subregion by building research ethics capacity in individuals and institutions and by strengthening the faculty and curriculum at the new MSc. in Bioethics Program at the University of Ghana. To achieve these aims, we will provide training and mentorship for faculty members at the UG Bioethics Program, co-create and implement a capacity building program designed to meet the needs of key institutions in Ghana’s research ethics system, and provide in-depth training and opportunities for professional development to 24 health professionals and academic researchers who will become experts in research ethics and integrity and leaders at their institutions. These activities will shape health research and research ethics in Ghana and the subregion to improve population health.

PI_NAMEs: CAPLAN, ARTHUR LEONARD;LAAR, AMOS  (contact);OGEDEGBE, OLUGBENGA G.

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: access disparities;Achievement;Address;Administrator;Africa;animation;authority;Bioethics;career development;Chronic;climate change;climate impact;cohort;Collaborations;Communities;Community of Practice;Country;COVID-19;curriculum enhancement;Death Rate;design;Development;diarrheal disease;Disease;Doctor's Degree;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Enrollment;Ensure;Ethical Review;Ethics;experience;Faculty;Fellowship;Fellowship Program;Food;Foundations;frontier;Funding Agency;Future;Gambia;Ghana;Goals;Government;Health;health care availability;Health Priorities;Health Professional;Health Services;Healthcare Systems;HIV/AIDS;Human Resources;improved;Indigenous;Individual;Institution;Institutional Review Boards;International;Investments;Joints;Lead;Liberia;Literature;low and middle-income countries;Malaria;Maternal Mortality;medical schools;member;Mentors;Mentorship;mortality;Needs Assessment;New York;Nigeria;Outcome;Output;Pharmaceutical Preparations;Phase;Philosophy;Play;population health;Positioning Attribute;Process;Program Evaluation;programs;Public Health Schools;Recording of previous events;Research;research and development;Research Ethics;Research Ethics Committees;Research Methodology;Research Personnel;Research Project Grants;research study;Role;Rural;Scholarship;Series;Shapes;Sierra Leone;success;System;Teacher Professional Development;Teaching Hospitals;Thinking;Training;Training Programs;Tuberculosis;United States National Institutes of Health;Universities;Update;urban disparity;USAID;vulnerable community;Work

PROJECT_TITLE: New York University-University of Ghana Research Integrity Training Program (NYU-UG RITP)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: Charlestown

ORG_NAME: MGH INSTITUTE OF HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE This project examines behavioral and neurocognitive correlates of reading to differentiate contributions of executive function (EF) weaknesses from ADHD status in dyslexia. Using a longitudinal design, this research aims to (1) bring a novel understanding of how ADHD diagnosis and EF weaknesses impact behavioral and neurocognitive reading growth among students with dyslexia, (2) offer a novel test of the Multiple Deficit Model, (3) offer novel data on EF brain networks in dyslexia, (4) and inform approaches for assessment and intervention for struggling readers. Our discovery of behavioral and neurocognitive reading growth will offer the largest and longest study of dyslexia to date, with insights as to whether EF or ADHD status may prevent some students with dyslexia from closing gaps in reading performance.

PI_NAMEs: CHRISTODOULOU, JOANNA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Affect;Age;Attention deficit hyperactivity disorder;behavior measurement;Behavioral;Brain;Child;clinical diagnosis;comorbidity;Corpus striatum structure;Data;Data Collection;data quality;Data Set;Development;Developmental reading disorder;Diagnosis;Diagnostic;diagnostic criteria;Disease;DSM-V;Dyslexia;Etiology;Exclusion;Executive Dysfunction;executive function;Exhibits;Functional Magnetic Resonance Imaging;Growth;Heterogeneity;improved;indexing;Inferior frontal gyrus;insight;Intervention;Lateral;Left;longitudinal design;Magnetic Resonance Imaging;Measures;meetings;Mission;Modeling;National Institute of Child Health and Human Development;Neurocognitive;Neurodevelopmental Disorder;neuroimaging;novel;Occipital lobe;Outcome;Participant;peer;Performance;prevent;Reader;Reading;reading difficulties;Recording of previous events;recruit;Reporting;Research;Research Design;Sampling;skills;Structure of middle temporal gyrus;Students;Superior temporal gyrus;Surveys;symptomatology;Testing;Theoretical model;theories;Time;Variant;Visit;Work

PROJECT_TITLE: Influence of ADHD and Executive Functions on Developmental Dyslexia

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Hematology;Human Genome;Liver Disease;Nutrition;Obesity

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Type 2 diabetes begins with resistance to insulin and then transitions to impaired insulin secretion by unknown mechanisms. We have identified novel mutations in Cela2a gene that cause impaired insulin secretion and sensitivity in patients with metabolic syndrome and diabetes. We aim to discover novel drug targets for diabetes by characterizing the gene and its targets in model animals, using novel molecular techniques.

PI_NAMEs: MANI, ARYA  (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Acinar Cell;Adipose tissue;Animal Model;Applications Grants;Atherosclerosis;Attenuated;Autologous Transplantation;Binding;Blood;blood glucose regulation;Blood Platelets;Blood Pressure;blood pressure regulation;Body mass index;Carrier Proteins;Cell membrane;Cells;chymotrypsin;Circulation;Closure by clamp;cohort;Cyclic AMP-Dependent Protein Kinases;Diabetes Mellitus;Disease;Disease Pathway;early onset;Eating;Elastases;Enzymes;Epithelial Cells;euglycemia;Exhibits;Exocrine pancreas;exome;Family;Fatty Acids;Fatty Liver;G-Protein-Coupled Receptors;gain of function;General Population;Genes;Genets;genome wide association study;Glucose;glucose metabolism;Goals;Health;Hepatic;Homeostasis;Human;human disease;human subject;Hyperglycemia;Hyperglycemic Mice;Hyperinsulinism;Hypertension;Hypertriglyceridemia;Impairment;in vitro activity;in vivo;Individual;Insulin;Insulin deficiency;Insulin Resistance;insulin secretion;insulin sensitivity;intestinal epithelium;islet;Islets of Langerhans;kindred;Knockout Mice;LDL Cholesterol Lipoproteins;Ligands;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;Liver;loss of function mutation;Membrane;Membrane Proteins;Metabolic;metabolic phenotype;Metabolic syndrome;Molecular;Molecular Mechanisms of Action;mouse model;Mus;Muscle;mutant;Mutation;mutation carrier;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Pancreas;Pancreatectomy;Pancreatic Elastase;Pathway interactions;Patients;Phenocopy;Phenotype;Physiological;PIK3CG gene;Plasma;Platelet aggregation;Proteins;Proteolysis;Proto-Oncogene Proteins c-akt;Regulation;Resistance;response;Risk Factors;Role;segregation;Sequence Analysis;Serine Protease;Signal Transduction;Site;skeletal tissue;Systems Biology;Techniques;Therapeutic;therapeutic target;Tissues;Total Pancreatectomy;trait;Triglycerides;uptake;Variant;Work

PROJECT_TITLE: The characterization of Cela2a, a novel disease gene for metabolic syndrome in health and diseases

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Inflammatory Bowel Disease;Microbiome

PHR: NARRATIVE The Gram-negative bacterial pathogens Escherichia coli and Salmonella infect the gastrointestinal tract and are leading causes of morbidity in diverse patient populations. Infections caused by these pathogens pose a significant and urgent threat to public health and developing new antimicrobial strategies that target these organisms with minimal impact on the gut microbiome are needed. The transition metal iron (Fe) is an essential nutrient for E. coli and Salmonella, and the Fe-acquisition systems these pathogens use to obtain Fe from the host may provide new non-traditional antibacterial approaches that target these pathogens.

PI_NAMEs: NOLAN, ELIZABETH M;RAFFATELLU, MANUELA  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Adherent Invasive Escherichia coli;Affect;Affinity;Anabolism;Anaerobic Bacteria;Anti-Bacterial Agents;Antibiotics;Antibodies;antimicrobial;Applications Grants;B-Lymphocytes;Bacteremia;beta-Lactams;Binding;Biology;Carrier Proteins;Cell Physiology;Colitis;Complex;Crohn's disease;Cytoplasm;Data;Dedications;design;Development;Diarrhea;Electron Transport;enteric pathogen;Enterobactin;Environment;Escherichia coli;Escherichia coli Infections;expectation;Foundations;Future;Gastrointestinal tract structure;Genes;Goals;Growth;gut colonization;gut inflammation;gut microbiome;Gut Mucosa;Immunization;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Iron;Laboratories;Mediating;Membrane;Meningitis;Metabolism;Metals;Microbe;microbiome composition;microbiota;Morbidity - disease rate;Mucous Membrane;Mus;mutant;non-typhoidal Salmonella;Nutrient;Organism;Outcome;Oxidation-Reduction;pathobiont;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;patient population;Patients;periplasm;Peyer's Patches;Process;Public Health;receptor;receptor expression;Reporting;Research;Respiration;Salmonella;Salmonella typhimurium;scaffold;secondary metabolite;Sepsis;Severity of illness;siderophore receptors;Siderophores;Site;System;Testing;Therapeutic;Transition Elements;United States;uptake;Urinary tract;Urinary tract infection;Work

PROJECT_TITLE: Harnessing iron acquisition to hinder enterobacterial pathogenesis

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE This work aims to further a technology that enables the study of genetic interactions in vivo with the goal of overcoming the one-gene-at-a-time approach to studying functional genomics in mouse models.

PI_NAMEs: MCMANUS, MICHAEL T (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;Adoption;Alleles;Animal Model;Animals;Antigen Targeting;B-Lymphocytes;Benchmarking;Bioinformatics;Biological Models;Biology;CD Antigens;Cell Line;Cells;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;CRISPR screen;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;Data Set;Development;Diabetes Mellitus;Disease;DNA Sequence Alteration;Etiology;experimental study;Flow Cytometry;functional genomics;Future;Gene Activation;Gene Combinations;gene interaction;Genes;Genetic;Genetic Epistasis;Genetic Recombination;Genetic study;genetic variant;Genetically Engineered Mouse;genome sequencing;Genomic approach;Genomics;Goals;Guide RNA;Heart;Human;human disease;human genome sequencing;in vivo;innovation;insertion/deletion mutation;Libraries;Malignant Neoplasms;Methodology;Methods;Modality;Modeling;Molecular Profiling;Monoclonal Antibodies;mouse model;Mus;mutant;Mutation;Nervous System Disorder;new technology;next generation;novel;Pathway interactions;Performance;Phenotype;Physiological;prime editor;programs;Publishing;Reagent;Reporter Genes;Reproducibility;Research;Resources;RNA library;single cell sequencing;Study models;T-Lymphocyte;Technology;technology validation;Testing;Time;tool;Transcript;Transgenic Mice;Validation;Work

PROJECT_TITLE: Orthogonal CRISPR GEMMs

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE According to the CDC, obesity has reached epidemic proportions, with over 60% of the U.S. population being overweight or obese, thus, there is a serious demand for the development of new therapeutics to combat obesity and its sequelae. Excess weight gain leads to dysfunction of mitochondria, essential organelles that convert ingested nutrients into energy that can be used by the body. Mitochondrial dysfunction within the brain is especially detrimental as the brain is critically involved in the regulation of body weight, therefore, by investigating mechanisms that can improve mitochondrial function in the brain, I hope to discover a novel, effective and safe target for the treatment of obesity.

PI_NAMEs: CLAFLIN, KRISTIN  (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Address;Adipose tissue;Adult;Amphibia;Animals;Appetite Depressants;ATP Synthesis Pathway;Attenuated;Biology;Body Weight;Body Weight decreased;Brain;brain control;Brain region;Brown Fat;Cardiovascular Diseases;career;career development;Cell Respiration;Cells;Central Nervous System;Chemicals;Chronic;combat;Consumption;Data;Data Set;Development;Development Plans;diet-induced obesity;Eating;Educational workshop;Electron Microscopy;energy balance;Energy Intake;Energy Metabolism;Epidemic;excessive weight gain;experimental study;Food Energy;Future;Gene Expression;Generations;Genetic;Glucose;High Fat Diet;Homeostasis;Homologous Gene;Hydrogen Peroxide;Hypertension;Hypothalamic structure;improved;in silico;Ingestion;Inner mitochondrial membrane;insight;Iowa;knock-down;Knock-out;Knockout Mice;Knowledge;Liver diseases;Mammals;Measures;Mentorship;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;mitochondrial dysfunction;mitochondrial uncoupling protein;Molecular;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Neurons;Neuropeptides;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;novel therapeutics;Nutrient;Obesity;obesity management;obesity prevention;obesity treatment;Organelles;overexpression;Overweight;oxidative damage;Oxidative Stress;Oxygen Consumption;Pathogenesis;pharmacologic;Physiological;Population;Positioning Attribute;Prevention;Production;Protons;Publications;Reactive Oxygen Species;Regulation;Research;Research Personnel;Respiration;Role;Secure;SF1;Signal Pathway;single-cell RNA sequencing;Structure of nucleus infundibularis hypothalami;symposium;Synaptosomes;targeted agent;Testing;Therapeutic;Thermogenesis;Training;Transcript;uncoupling protein 1;Universities;Viral;viral rescue;Viral Vector;Weight Gain

PROJECT_TITLE: Regulation of neuronal function by mitochondrial uncoupling


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse;Women's Health Research

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE: In this proposal we investigate the function of discrete neuronal activity dynamics that emerge in the prefrontal cortex while animals reinstate heroin seeking, and how such activity is modulated by both progesterone and its metabolite allopregnanolone as they suppress reinstatement. The proposed research is relevant to public health as elucidating the precise mechanisms underlying drug-seeking behavior can guide development of more effective treatment approaches for opioid use disorder. The proposed research is, furthermore, relevant to NIH's mission as it pertains to developing fundamental knowledge that will contribute to the understanding of neural circuits that underlie motivated behaviors.

PI_NAMEs: DONCHECK, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Affect;Allopregnanolone;analog;Animals;Behavior;Behavioral;Biological Assay;Biological Process;biological sex;calcium indicator;career;Cells;Clinical;cocaine seeking;craving;Cues;Data;Development;Disease;Drug Recalls;drug seeking behavior;Drug usage;effective therapy;Enterobacteria phage P1 Cre recombinase;executive function;Exhibits;Exposure to;Extinction;FDA approved;Female;GABA-A Receptor;Glutamates;Goals;Head;Health;Heroin;Hormonal;hormone regulation;Hormones;in vivo calcium imaging;Individual;Intervention;Knowledge;Label;Light;male;Mediating;Mentors;Mission;Monitor;motivated behavior;Mus;neural;neural circuit;neurobiological mechanism;neuromechanism;Neurons;neurosteroids;novel;Nucleus Accumbens;Opioid;opioid use disorder;Opsin;optogenetics;Output;Ovarian Cycles;Ovarian hormone;Oxidoreductase;Pathway interactions;Pattern;Pharmaceutical Preparations;Phase;positive allosteric modulator;Predisposition;Prefrontal Cortex;prevent;Progesterone;programs;Public Health;Publications;receptor;redshift;Regulation;Relapse;Reporting;Research;Research Personnel;Resolution;response;reward circuitry;Rewards;Role;Self Administration;sex;Sex Differences;Site;Substance Use Disorder;Testing;Time;Training;translational potential;United States National Institutes of Health

PROJECT_TITLE: Progesterone and allopregnanolone of prefrontal cortical activity dynamics and heroin seeking

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-S-K]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: PABLO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: SALISH KOOTENAI COLLEGE

ORG_STATE: MT

PHR: PROJECT NARRATIVE Native Americans are a vastly underrepresented minority population across all scientific disciplines. Herein, “Advancing Resource & Research Opportunities in Environmental Health Sciences (ARRO-EHS)” proposes to strengthen the academic and research ecosystem at Salish Kootenai College (SKC), a Native American serving tribal college, resulting in more competitive students for advanced degree programs in environmental health sciences. The program also proposes to promote a more diverse work force in the field of environmental health sciences through the training of confident and capable leaders with a unique tribal, environmental, and community perspective.

PI_NAMEs: COMSTOCK, CLAY EDWARD SCOTT (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Affinity;Area;Biological Sciences;Catalogs;Cells;college;Communities;Competence;Dedications;Degree program;design;Discipline;Ecosystem;Education;educational atmosphere;Educational Curriculum;Educational workshop;Employment;empowerment;Environment;Environmental Health;experience;Faculty;faculty mentor;falls;Family;Funding;Health;improved;Indian reservation;Indigenous;Infrastructure;innovation;Institution;Internships;Knowledge;Labor Forces;Mainstreaming;Mentors;Minority Groups;Molecular Biology;Montana;Native Americans;novel;outreach;peer;Preparation;programs;Research;Research Project Grants;Resources;Salish and Kootenai;Salish Kootenai College;Science;Secondary Schools;Services;skills;socioeconomics;student participation;Students;tool;Training;Training and Education;tribal college;Tribes;undergraduate education;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Advancing Resource & Research Opportunities in Environmental HealthSciences (ARRO-EHS)”


ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Narrative: Cytomegalovirus (CMV) is the most common infectious cause of birth defects in the developed world, and therefore a major target for immune interventions that will disrupt viral transmission to new hosts or spread within a host. CMV enters hosts through mucosal barrier tissues, where it avoids rapid immune control by unknown mechanisms and then escapes to distant tissues. The aim of this proposal is to define mechanisms that limit T cell control of CMV in a natural mucosal site of entry and to determine how T cells modulate viral persistence and dissemination to distant tissues.

PI_NAMEs: SNYDER, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acceleration;Address;Adenosine;ADORA2A gene;Adult;Anti-Inflammatory Agents;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Child;Cognitive;Congenital Abnormality;congenital cytomegalovirus;Cytomegalovirus;Cytomegalovirus Infections;Data;Distant;Environment;Enzyme-Linked Immunosorbent Assay;Epithelium;experimental study;extracellular;Fetus;fluorophore;Goals;Health;hearing impairment;Hematopoietic;high risk;Histologic;Human;Immune;Immune response;Immune system;Immune Targeting;immunological intervention;immunoregulation;Immunosuppression;Infection;Institute of Medicine (U.S.);Knockout Mice;Knowledge;Lipids;Mass Spectrum Analysis;Mental disability;Morbidity - disease rate;Mothers;motor deficit;Mouse Strains;mucosal site;Mucous Membrane;Mus;Myeloid Cells;Nasal cavity;Nasopharynx;Newborn Infant;Nose;novel;Occupations;Outcome;pathogen;Pathway interactions;Persons;Pharyngeal structure;Predisposition;Pregnancy;prevent;Primary Infection;Production;Public Health;Purinergic P1 Receptors;Regulatory Pathway;Resistance;Role;Route;Salivary Glands;Series;Signal Transduction;Site;Stream;Structure of mucous membrane of nose;T-Lymphocyte;Testing;Time;tissue resident memory T cell;Tissues;transmission process;United States;Vaccines;Viral;viral transmission;Virus;Virus Replication;Visual impairment

PROJECT_TITLE: T cell control of MCMV and tissue-localized immune suppression

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Hearing Loss;Neurodegenerative;Neurosciences;Rehabilitation

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE Changes to auditory midbrain structure and function resulting from aging and age-related hearing loss may lead to neural hyperactivity and distorted neural representations of sound, which may underlie speech recognition difficulties. This project uses electrophysiology, neuroimaging, and behavioral methods to study the extent to which the auditory midbrain creates an exaggerated and atypical representation of the temporal features of sound, and whether this atypical representation is related to impaired speech recognition for older adults in challenging listening conditions. A better understanding of the extent to which neural hyperactivity and distorted temporal processing is present in the auditory midbrain of older adults and those with age-related hearing loss can inform future studies of subcortical neural hyperactivity and work towards improving speech communication outcomes.

PI_NAMEs: MCCLASKEY, CAROLYN MARIE (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TITLE: Age and hearing loss effects on subcortical neural encoding

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: PROJECT NARRATIVE This proposal will use genetic and computational tools to evaluate and facilitate the preclinical utility of patient- derived xenograft (PDX) models for the three most common subtypes of pediatric solid tumors: Osteosarcoma, Ewing sarcoma and Rhabdomyosarcoma (alveolar and embryonal). We will also develop novel PDX models that incorporate CRISPR/Cas9 and also have a humanized immune system. A key component is reagent/model/data sharing to enable and accelerate research in to these rare “orphan” diseases.

PI_NAMEs: SWEET-CORDERO, ERIC ALEJANDRO (contact);VASKE, OLENA MOROZOVA

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Acceleration;Advanced Development;Allogenic;Alveolar;Animal Model;Autologous;Biological;Biological Models;cancer genomics;candidate identification;Cells;chemotherapy;Childhood Solid Neoplasm;Clinical;clinical care;Clinical Trials;clinically relevant;Clonal Evolution;Collaborations;Collection;Combined Modality Therapy;Communities;Computational Biology;computerized tools;Computing Methodologies;Credentialing;CRISPR screen;CRISPR/Cas technology;Data Set;data sharing;Development;Disease;Drug resistance;Drug Targeting;drug testing;early phase clinical trial;Environment;Evolution;Ewings sarcoma;functional genomics;Gene Cluster;Gene Expression;Generations;Genes;Genetic;genetic analysis;genetic technology;Genetic Transcription;genome sequencing;Genomic approach;genomic tools;Genomics;Goals;Heterogeneity;Histologic;Human;Immune;Immune system;Immunocompetent;Immunocompromised Host;Immunogenomics;Individual;innovation;Malignant Childhood Neoplasm;Malignant Neoplasms;Mammalian Cell;member;Methods;model development;Modeling;Molecular;Mus;novel;novel strategies;novel therapeutics;Oncology;Osteosarcoma;Pathway interactions;patient derived xenograft model;Patients;Pediatric Oncologist;pediatric patients;Phenotype;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical development;Preclinical Testing;Primary Neoplasm;programs;Rare Diseases;Reagent;Research;Research Personnel;Resistance;Resolution;response;Rhabdomyosarcoma;single-cell RNA sequencing;System;targeted treatment;Technology;Testing;therapy design;therapy resistant;tool;transcriptome sequencing;Translating;translational scientist;treatment response;tumor;tumor heterogeneity;Validation;whole genome;Work

PROJECT_TITLE: Development of Advanced Preclinical Models for Pediatric Solid Tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-J(55)R]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The goal of our research is to develop new biomarkers of pancreatic islet autoimmunity, which occurs before the development of clinical type 1 diabetes. Insights obtained from this project will improve our understanding of type 1 diabetes pathogenesis, provide robust and reproducible markers for the earliest stages of diabetes development, and aid in monitoring diabetes-specific immune responses following therapies being tested to prevent disease onset.

PI_NAMEs: MICHELS, AARON W (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Age;Antibodies;Antigens;Appearance;Autoantibodies;Autoantibody binding;Autoantigens;autoreactive T cell;Biological Assay;Biological Markers;Birth;CD8B1 gene;Child;Clinical;clinical development;cohort;deamidation;Development;Diabetes Mellitus;diabetes pathogenesis;Diabetes prevention;disease heterogeneity;DNA;endocrine pancreas development;Epitopes;experimental study;Frequencies;Funding;Genes;Goals;HLA-DR Antigens;Human;Hybrids;Immune response;immunoregulation;improved;Individual;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;islet;islet autoimmunity;islet cell antibody;Islets of Langerhans;Knowledge;Measurement;Measures;Monitor;multiplex assay;Natural History;non-diabetic;Onset of illness;Organ Donor;Patient Selection;patient subsets;Patients;Peptides;peripheral blood;Population;pre-clinical;Predictive Value;prevent;Prevention;prospective;Proteins;Reproducibility;Research;Residual state;Ribosomes;Sampling;Serum;sex;Specificity;T cell infiltration;T-Cell Receptor;T-Lymphocyte;Testing;Time;Translating;Whole Blood

PROJECT_TITLE: Multiple Autoantigens, Multiple Epitopes of Type 1 Diabetes

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Complementary and Integrative Health;Genetics;Human Genome;Natural Products

ORG_DEPT: GENETICS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative: Bacterially produced small molecules (i.e., natural products) have inspired many of the most important therapeutics in use today. Large-scale sequencing of bacterial (meta)genomes has revealed that the biosynthetic diversity traditionally explored in the laboratory by fermentation represents only a small fraction of what is predicted to exist in nature. This proposal brings together advanced bioinformatics, next-generation metagenomics, and total chemical synthesis to identify new antiproliferative agents that are inspired by biosynthetic gene clusters that have remained inaccessible using other natural product discovery approaches.

PI_NAMEs: BRADY, SEAN F (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Algorithms;Animal Model;Anti-tumor Natural Products;Antibiotics;antimicrobial;Antineoplastic Agents;antiproliferative agents;Bacteria;Bacterial Genome;Bacterial natural products;bioactive natural products;Bioinformatics;Biological Process;Biology;Breathing;Cancer cell line;Chemical Structure;chemical synthesis;Clinical;Cloning;Collection;cytotoxic;Data;design;Development;DNA;drug discovery;Enzymes;Family;FDA approved;Fermentation;Funding;Future;Gene Cluster;Genetic;Genetic Transcription;Genome;Genomics;Goals;Human;In Vitro;in vivo;Instruction;Laboratories;laboratory experiment;Large-Scale Sequencing;Lead;Libraries;Malignant Neoplasms;metagenome;Metagenomics;Methodology;Methods;Microbial natural product;microbiome;Modeling;mutant;Natural History;Natural product discovery;Natural Products;Nature;next generation;novel;novel anticancer drug;Peptide Biosynthesis;peptide structure;peptide synthase;Peptides;Pharmaceutical Preparations;polyketides;pressure;programs;public database;Resistance;Rewards;Sampling;screening;small molecule;Soil;Source;Structure;Study models;success;Therapeutic;therapeutic development;Translations

PROJECT_TITLE: Discovery and characterization of synthetic bioinformatic natural product anticancer agents

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Narrative The studies proposed will identify and differentiate neural networks within the grey matter of the spinal cord that subserve different functions and which may be detected using functional MRI. The patterns of connections between different sub-regions of the cord will be quantified before and after targeted interventions that are intended to disrupt specific functions. The interpretation of functional MRI measurements will be validated using electrophysiology and post-mortem histology.

PI_NAMEs: CHEN, LI MIN ;GORE, JOHN C (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Ablation;Acute;Address;Affect;Anatomy;Anesthetics;Architecture;Autopsy;Axon;Behavior;Behavior monitoring;Behavioral;Cervical spinal cord structure;Cervical spine;Chemicals;Complex;Data;deep learning;Diffusion Magnetic Resonance Imaging;dorsal column;Electrophysiology (science);Evolution;Exhibits;Functional Magnetic Resonance Imaging;Funding;Grain;grasp;Gray Commissure;gray matter;Hand;Hand functions;Histologic;Histology;Home;Horns;Human;imaging modality;Impairment;indexing;Injury;Intervention;Left;Lesion;Link;Magnetic Resonance Imaging;Measurement;Measures;Methods;microstimulation;millimeter;Modeling;Modification;Molecular;Monitor;Monkeys;Motor;Motor Cortex;Motor Neurons;Motor Pathways;multiparametric imaging;myelination;neural;neural network;nonhuman primate;Opioid;Pattern;Performance;pharmacologic;Posterior Horn Cells;Primates;Recovery;Reporting;Research;Rest;Saimiri;Sensory;sensory input;Severities;Signal Transduction;skills;Slice;Spinal;Spinal Cord;Spinal cord grey matter structure;Spinal cord injury;Spinal Cord Lesions;Spinal Dorsal Nerve;Spinal nerve root structure;Structure;System;Tracer;treatment effect;Vertebral column

PROJECT_TITLE: Resting State Connectivity in Primate Spinal Cord

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Brain Disorders;Maternal Health;Mental Health;Mental Illness;Pediatric;Pregnancy;Schizophrenia;Serious Mental Illness;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Mental health conditions are common among pregnant and postpartum women, and there is an urgent need to develop timely evidence regarding the safety of antipsychotic medications when used during pregnancy. We propose developing and implementing TreeScan, a novel signal detection method, for simultaneous evaluation of a broad range of potential maternal, fetal and neonatal adverse outcomes as part of a near real-time active safety surveillance system for antipsychotic medication use in pregnancy. Such an approach will not only avoid unnecessary exposure for mother and fetus to potentially harmful medications but, equally important, will provide re-assurance when no large harmful effects are detected so that women are not unnecessarily deprived of important medications for the treatment of psychiatric disorders.

PI_NAMEs: HUYBRECHTS, KRISTA F (contact);WANG, SHIRLEY

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Accounting;Adverse effects;adverse maternal outcomes;adverse outcome;adverse pregnancy outcome;Age;Animals;Antipsychotic Agents;Area;Bipolar Disorder;case control;Clinical;cohort;Cohort Studies;comparative;Congenital Abnormality;Counseling;Data;Data Sources;Databases;design;detection method;Diagnosis;Discipline of obstetrics;Disease;drug structure;Equilibrium;Etiology;Evaluation;evidence base;Exclusion;Feeds;fetal;Fetus;health care service utilization;Health Personnel;Human;Individual;interest;Marketing;maternal outcome;maternal risk;medication safety;member;Mental disorders;Mental Health;Methods;Mothers;Neonatal;neonatal outcome;Newborn Infant;novel;novel strategies;offspring;Outcome;Patients;Perinatal;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacology;Population;post-market;Postpartum Women;Pregnancy;Pregnant Women;Privatization;Process;prospective;Psychiatric therapeutic procedure;Psychiatry;Public Health;Registries;relapse risk;Reporting;reproductive;Research Personnel;Risk;Safety;Scanning;Schizophrenia;screening;Signal Transduction;System;teratogenesis;Teratogens;Testing;Therapeutic Trials;Time;Tissues;topiramate;Trees;vaccine safety;venlafaxine;Woman;women's treatment

PROJECT_TITLE: Active Surveillance of the Safety of Antipsychotic Medications in Pregnancy

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative: Leukemias with rearrangements of the MLL (KMT2A) gene, classically seen in infants and therapy-related leukemia, remain difficult to treat and cure even with modern therapies. These leukemias highly express an RNA binding protein, MBNL1, which regulates alternative RNA splicing and is essential for leukemia cell survival. The proposed research will explore the mechanisms underlying this dependence, and further develop a new and much-needed targeted therapy against this protein for this high-risk group of leukemias.

PI_NAMEs: LEE, LYNN HUA (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acute Myelocytic Leukemia;Alternative Splicing;B-Lymphocytes;Binding;Bone Marrow Transplantation;cancer therapy;career development;Cell Death;cell growth;Cell Line;Cell Survival;Characteristics;chemotherapy;Child;Clinical;clinical care;Complex;crosslink;Cytotoxic Chemotherapy;Dependence;Development Plans;Disease;Docking;effective therapy;efficacy validation;Eukaryota;experimental study;Family;Family psychotherapy;Gene Expression;Gene Rearrangement;Genes;Genetic;Genetic Transcription;Goals;Hematopoietic;high risk population;Immunoprecipitation;Impairment;improved;improved outcome;in silico;In Vitro;in vivo;Individual;infancy;Infant;Infant Leukemia;inhibitor;instructor;knock-down;Laboratories;Lead;leukemia;Leukemic Cell;leukemogenesis;Libraries;Malignant Neoplasms;Mediating;Medical center;member;Mentors;Messenger RNA;Mixed-Lineage Leukemia;MLL gene;MLL-rearranged leukemia;Modality;Modernization;Molecular;mRNA Precursor;Mutation;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Oncology;Outcome;Pathogenesis;Pathway interactions;patient subsets;Patients;Pattern;pediatric acute leukemia;Pediatric Hospitals;Pharmaceutical Chemistry;pharmacologic;Physicians;Physiological;Positioning Attribute;Predisposition;progenitor;Prognosis;programs;Proteins;Publishing;rational design;Research;Research Personnel;response;RNA Splicing;RNA-Binding Proteins;Role;Scientist;Secondary acute myeloid leukemia;small molecule;small molecule inhibitor;Spliceosomes;stem;Stem cell transplant;Structure;Subgroup;targeted treatment;Testing;Therapy-Related Acute Myeloid Leukemia;transcriptome sequencing;translational impact;Work

PROJECT_TITLE: Targeting MBNL1-mediated alternative splicing in MLL-fusion leukemia

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Mental Health;Mental Illness;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative: Measurement based care (MBC) is an emerging best practice involving serial assessment of clinical status and using those findings to inform clinical decision making. However, there is a lack of research on how to best apply principles of MBC for patients with bipolar disorder. Project goals are to determine which validated bipolar disorder instrument is most acceptable and helpful in clinical care, demonstrate that the preferred instrument can be used to monitor outcomes with high fidelity in routine care, and assess feasibility of comparing effectiveness of MBC to enhanced usual care in a randomized trial.

PI_NAMEs: BLANCHARD, BRITTANY ELIZABETH (contact);CERIMELE, JOSEPH M.

PROGRAM_OFFICER_NAME: DAVIS, BESHAUN JAMAAL

PROJECT_TERMS: Adoption;arm;Assessment tool;behavioral health;Bipolar Disorder;Caring;Clinic;Clinical;clinical care;clinical decision-making;clinical practice;compare effectiveness;Consensus;Country;Data;depressive symptoms;Development;Diagnosis;Effectiveness;effectiveness trial;experience;Goals;Health Care Quality Assurance;health care service organization;health organization;Impairment;improved;Individual;instrument;Joints;Literature;Manic;Measurement;Measures;Mental Depression;Mental disorders;Monitor;National Committee for Quality Assurance;National Institute of Mental Health;Outcome;Outcome Measure;Patient Care;Patient Outcomes Assessments;Patient Self-Report;Patient-Focused Outcomes;Patients;Persons;Population;Positioning Attribute;programs;Property;Protocols documentation;Psychometrics;Qualitative Methods;Quality of life;Randomized;randomized effectiveness trial;randomized trial;Recommendation;Relapse;Research;routine care;Severities;standard of care;Standardization;Strategic Planning;Surveys;Symptoms;System;systematic review;Testing;Time;treatment as usual;treatment response;trial comparing;Uncertainty;uptake;Work

PROJECT_TITLE: Bipolar disorder measures in clinical care


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Bioengineering;Data Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This dissertation proposal highlights the continuing burden of HIV that affects adolescent girls and young women in sub-Saharan Africa. Although individual behaviors and attitudes are influenced by many interpersonal, community, and societal factors, HIV prevention research has focused on the individual as the risk-taker and therefore, the primary target for HIV prevention interventions. This study will go beyond the individual to inform the development of community and societal HIV prevention approaches and model interventions that promise the most benefit to adolescent girls and young women.

PI_NAMEs: REED, DOMONIQUE M (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent;Adolescent HIV risk;Advanced Development;Affect;Africa South of the Sahara;African American;Age disparity;aged;AIDS prevention;Algorithms;Alternative Therapies;analytic epidemiology;analytical tool;Area;Assessment tool;Attitude;Behavior;Behavioral Sciences;big-data science;Biological;burden of illness;Cameroon;career;Censuses;Characteristics;Communities;Community Developments;community-level factor;Complex;Computing Methodologies;contextual factors;Country;Dangerousness;Data;data integration;Data Science;Data Set;Data Sources;Development;Disease Pathway;Education;Effectiveness;Environment;Epidemic;Epidemiology;experience;Feedback;Female Adolescents;Fostering;Foundations;Future;gender disparity;Goals;health disparity;health seeking behavior;high risk;high risk sexual behavior;HIV;HIV disparities;HIV Infections;HIV risk;HIV Seropositivity;Housing;improved;Individual;Infection;innovation;interest;Intervention;intervention effect;Knowledge;knowledge base;Laws;Malawi;Measurement;Mental Depression;Mentorship;Methodology;Mission;Modeling;National Institute of Mental Health;novel;Pathway interactions;Pattern;Policies;Population;population based;pre-exposure prophylaxis;preservation;Prevention;Prevention approach;Prevention Research;preventive intervention;Principal Investigator;Process;Psyche structure;Public Health;Recording of previous events;Research;Research Personnel;Research Priority;Risk;Risk Assessment;Risk Factors;Role;Rwanda;Science;Scientific Inquiry;Scientist;Sexually Transmitted Diseases;Social Processes;Societal Factors;Societies;Source;structural determinants;Structure;Techniques;therapy design;therapy development;Training;transactional sex;trend;Uganda;Vulnerable Populations;young woman

PROJECT_TITLE: Moving Beyond the Individual- A Data-driven Approach to Improving the Evidence on the Role of Community and Societal Determinants of HIV among Adolescent Girls and Young Women in Sub-Saharan Africa


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Project Narrative In this project we will determine the roles of specialized myxoma virus-loaded white blood cells, called tumor- specific T cells, in promoting an immune response against solid tumors in mice and determine their potential for use in cancer adoptive cell immunotherapy. We hypothesize that transfer of these tumor-specific T cells will eradicate large established tumors and prevent recurrence in vivo in both mouse and human tumor models, due to their ability to 1) directly kill the tumor cells; 2) release myxoma virus to tumor cells, and 3) induce autosis in tumor cells to eliminate tumor with high heterogeneity in tumor antigen expression.

PI_NAMEs: LU, YONG  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Immunotherapy;Antigen Targeting;Antigens;Apoptosis;Cell Death;cell killing;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;complement C2a;Data;DNA Viruses;effector T cell;Endowment;European;Event;Exertion;Foundations;Future;Heterogeneity;Human;Immune response;Immunity;Immunocompetent;immunodeficiency;In Vitro;in vivo;Leukocytes;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Melanoma;mesothelin;Modeling;Molecular;mouse model;Mus;Myxoma virus;Nature;neoplastic cell;novel;Oncolytic viruses;Oryctolagus cuniculus;Pathogenicity;patient derived xenograft model;Patients;pre-clinical;prevent;Proto-Oncogene Proteins c-akt;Rag1 Mouse;Recurrence;Resistance;response;Role;Signal Transduction;SKOV3 cells;Solid Neoplasm;synergism;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic Index;treatment response;tumor;Tumor Antigens;tumor eradication;tumor heterogeneity;Tumor Immunity;tumor xenograft;Viral load measurement;Work

PROJECT_TITLE: Induction of autosis to overcome resistance in adoptive cell therapy for solid tumors

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ORG_CITY: EAST LANSING

ORG_DEPT: CHEMISTRY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (NARRATIVE) (Project Title: Folding and Degradation of Membrane Proteins) Imbalances between membrane protein folding and degradation is a cause of a number of human diseases, via inefficient folding and excessive degradation caused by inherited mutations, or overwhelming aggregation of misfolded proteins beyond cellular degradation capacity. Using our steric trapping approach for studying membrane protein folding as well as the feasible model system for studying detailed mechanisms of degradation, we will provide the basic principles for understanding membrane protein misfolding and associated disease mechanisms.

PI_NAMEs: HONG, HEEDEOK  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Affect;ATP-Dependent Proteases;Biological Models;Cell membrane;Cells;Chemicals;design;Disease;Engineering;Environment;Escherichia coli;Eukaryotic Cell;Goals;human disease;In Vitro;Inherited;innovation;Knowledge;Learning;Lipid Bilayers;Mediating;Membrane;Membrane Proteins;Methodology;Methods;misfolded protein;Modeling;Molecular;Molecular Chaperones;Monitor;Mutation;novel;Outcome Study;Peptide Hydrolases;physical property;Physiological;programs;Prokaryotic Cells;Property;protein degradation;protein folding;protein misfolding;protein protein interaction;Proteins;Proteome;public health relevance;Quality Control;Research;Signal Pathway;Solvents;stem;Stress Response Signaling;System;thermophilic organism;thermostability;Vision;Water

PROJECT_TITLE: Folding and degradation of membrane proteins

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The high abuse rates of therapeutic opioids have fueled a strong debate on the treatment practices of using prescription opioids and whether pain is a major factor in addiction susceptibility. The present proposal will use preclinical rodent models of chronic pain to investigate the impact of pain on opioid drug taking and relapse with a focus on understanding the contribution of the kappa opioid receptor system within the amygdala. A better understanding of kappa opioid receptors and its endogenous ligand dynorphin in mediating emotional- affective aspects of motivated behaviors in chronic pain states has translational significance for the advancement of KOR antagonists as novel therapeutics for treating opioid use disorder.

PI_NAMEs: CAHILL, CATHERINE M (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Address;Affective;Alcohol consumption;Amygdaloid structure;Anhedonia;animal pain;Animals;Anxiety;Attenuated;Behavior;biological adaptation to stress;Bipolar Disorder;Brain region;Cell Nucleus;Central Lateral Nucleus;Chronic;chronic pain;chronic pain patient;Consumption;Corticotropin-Releasing Hormone;Data;Development;Drug Exposure;drug relapse;drug seeking behavior;drug withdrawal;Dynorphins;Emotional;Exhibits;experience;Extinction;Fiber;Genetic;genetic approach;Genetic Models;Heavy Drinking;Hypothalamic structure;in vivo;Internal Ribosome Entry Site;Intravenous;kappa opioid receptors;Lead;Learning;Ligands;Mediating;Medical;Medical Records;Mental Depression;Mental disorders;Messenger RNA;Modeling;motivated behavior;mouse model;Mus;negative affect;Negative Reinforcements;Neurons;Nociception;norbinaltorphimine;novel therapeutics;Opiate Addiction;Opioid;Opioid agonist;Opioid Antagonist;opioid epidemic;opioid injection;opioid misuse;opioid overdose;opioid use disorder;Pain;Pain Disorder;Pain intensity;pain-related disability;parabrachial nucleus;Patients;Persistent pain;Pharmaceutical Preparations;pharmacologic;Photometry;pre-clinical;Predisposition;preference;prescription opioid;Prevalence;Process;Protocols documentation;Psychopathology;Receptor Activation;receptor expression;receptor function;Receptor Signaling;Receptor Up-Regulation;receptor upregulation;Relapse;Reporting;Research Project Grants;Reverse Transcriptase Polymerase Chain Reaction;reward dysfunction;Rewards;Risk Factors;Rodent Model;Self Administration;Sensory;sensory input;Spinal Cord;Stimulus;Stress;Suicide;System;Testing;therapeutic opioid;Time

PROJECT_TITLE: Amygdala kappa opioid system involvement in opioid relapse in pain states

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Hematology;Lung;Lung Cancer;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative: The oxidative pentose phosphate pathway (oxiPPP) regulates cell metabolism by producing metabolic intermediates and reductive NADPH, and inhibiting LKB1-AMPK signaling through ribulose-5-phosphate (Ru-5-P), the product of the third enzyme 6-phosphogluconate dehydrogenase (6PGD). We provide evidence supporting that γ-6-phosphogluconolactone (γ-6PGL), a “dead end” byproduct of the oxiPPP with unknown physiological function, serves as a signaling molecule that contributes to AMPK activation by enhancing inhibition of AMPK upstream phosphatase PP2A by Src. Thus, we hypothesize that oxiPPP regulates AMPK homeostasis by balancing the opposing LKB1 and PP2A.

PI_NAMEs: CHEN, JING  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: 6-phosphogluconate;A549;Acetylation;Acute;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Affect;Anabolism;Antioxidants;attenuation;Binding;cancer cell;Cell Proliferation;Cells;Cellular Metabolic Process;Colorectal Cancer;Combined Modality Therapy;Complex;Enzymes;Focal Adhesion Kinase 1;Foundations;Gene Expression;Glucose-6-Phosphate;Glucosephosphate Dehydrogenase;Glycolysis;H1299;HCT116 Cells;Homeostasis;HT29 Cells;Human;Hydrolysis;In Vitro;in vivo;inhibitor;K-562;knock-down;leukemia;Link;lipid biosynthesis;lung cancer cell;Lysine;macromolecule;Malignant neoplasm of lung;Metabolic;Metabolic Pathway;Mitochondria;Molecular;mouse model;NADP;novel;Nucleotide Biosynthesis;Oncogenic;Oxidation-Reduction;Pathway interactions;patient derived xenograft model;Patients;Pentosephosphate Pathway;Phosphogluconate Dehydrogenase;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Play;Post-Translational Protein Processing;Probability;programs;Proliferating;Property;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Reactive Oxygen Species;recruit;Regulation;Reporting;response;ribulose 5-phosphate;Role;Series;Signal Pathway;Signal Transduction;Signaling Molecule;SOD2 gene;STK11 gene;Testing;tumor growth

PROJECT_TITLE: Oxidative pentose phosphate pathway regulates AMPK homeostasis by balancing opposing LKB1 and PP2A

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Genetics;Machine Learning and Artificial Intelligence;Pediatric

PHR: Type 1 diabetes causes significant increases in morbidity and mortality, and is responsible for considerable social and economic costs. A cure is urgently needed, but current gaps in our knowledge of its etiology, and a paucity of mechanistic biomarkers, are major impediments. This study proposes to fill these gaps by identifying biomarkers that can predict rates of future disease progression.

PI_NAMEs: DAVIDSON, HOWARD W (contact)

PROJECT_TERMS: Address;Age;Autoimmune;Autoimmune Diabetes;Beta Cell;Biological Assay;Biological Markers;biomarker identification;biomarker panel;Cells;Clinical;Clinical Data;clinical development;clinical diagnosis;Clinical Trials;clinically actionable;clinically relevant;cohort;Complex;Data;Data Collection;Data Set;Development;Diabetes Mellitus;Diagnosis;Disease;Disease Progression;DNA;DNA redundancy;E-learning;economic cost;Economics;effective therapy;efficacy evaluation;Elasticity;Etiology;experience;feature selection;Future;Gender;Goals;Heterogeneity;high throughput screening;Immune system;Immunologics;improved;improved outcome;Individual;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention Trial;Kinetics;Knowledge;Machine Learning;machine learning algorithm;Mediating;member;Metabolic;Modeling;Monitor;Morbidity - disease rate;mortality;multimodality;Natural History;Newly Diagnosed;Partial Remission;Patients;Performance;peripheral blood;Persons;Play;predictive modeling;protein function;Proteins;Randomized;recruit;Regulation;Replacement Therapy;responders and non-responders;Risk;RNA;Series;social;Societies;Stratification;Testing;tool;Training;transcriptome;Validation;Wing;Youth

PROJECT_TITLE: Multimodal analysis of the "honeymoon period" in autoimmune diabetes

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Neurosciences;Pediatric;Rare Diseases;Spina Bifida;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: The mechanisms regulating the earliest stages of neural tube closure are poorly understood in humans. The proposed studies will uncover a novel post-transcriptionally regulated mechanism governing neuroepithelial differentiation and neural tube formation. Discoveries from this work will improve our ability to diagnose and potentially treat neural tube closure defects.

PI_NAMEs: FINNELL, RICHARD H.;PARCHEM, RONALD J (contact)

PROGRAM_OFFICER_NAME: KOSTER, MARANKE IRENE

PROJECT_TERMS: ATAC-seq;Cell Differentiation process;Cell Nucleus;cell type;Cells;Chicken Model;Chickens;Chromatin;Cilia;cohort;Congenital Abnormality;Critical Pathways;Data;Defect;Development;Diagnosis;Disease;Ectoderm;Embryo;Erinaceidae;Evolution;exome sequencing;experimental study;Expression Profiling;Family;folic acid supplementation;gain of function;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Transcription;genome sequencing;Genomic DNA;Goals;Histologic;Human;human embryonic stem cell;human model;improved;In Situ;In Vitro;in vivo;Infant;insight;Intervention;Knock-out;Knockout Mice;Ligation;Link;loss of function;Maps;Messenger RNA;MicroRNAs;Molecular;Mouse Embryonic Stem Cells;mouse model;Mus;Mutate;Mutation;Mutation Detection;nerve stem cell;neural;Neural tube;Neural Tube Closure;Neural Tube Defects;Neural Tube Development;Neuroepithelial;Neuroepithelial Cells;neuroepithelium;neuroregulation;novel;Nuclear;Organoids;Pathogenicity;Pathway interactions;Patients;Phenotype;planar cell polarity;Play;pluripotency;posttranscriptional;prenatal;Prevalence;prevent;Process;programs;Public Health;Regulation;Regulatory Element;Reporter;Research;Resolution;Role;Sampling;single cell analysis;single-cell RNA sequencing;smoothened signaling pathway;SOX1 gene;Structural Congenital Anomalies;Structure;System;Testing;Transcript;transcriptome sequencing;Untranslated RNA;Variant;virtual;whole genome;Wild Type Mouse;Work

PROJECT_TITLE: MicroRNA regulation of neural tube closure

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Pediatric;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE  Pediatric physician-scientists play a vital role in advancing knowledge related to child health and disease. For the past 26 years, this Child Health Research Center program has successfully supported the mentored career development of pediatric physician-scientists by optimally utilizing the collaborative environment and state-of-the art scientific and technical resources of the Washington University School of Medicine.

PI_NAMEs: SILVERMAN, GARY ARTHUR (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: animal model development;Area;Basic Science;Benchmarking;Bioinformatics;Biology;biomedical resource;career development;Cellular biology;Child Health;Child Support;Childhood;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Core Facility;Cryoelectron Microscopy;Development;Developmental Biology;Discipline;Disease;Doctor of Philosophy;Education;experience;Faculty;Feedback;Generations;Genetic;genome editing;Genomics;Goals;Image;Immunology;improved;Institution;Investigation;Knowledge;Laboratories;Leadership;Mass Spectrum Analysis;medical schools;Medicine;Mentored Clinical Scientist Development Program;Mentors;metabolomics;metagenomic sequencing;next generation;Pathway interactions;pediatric department;Physicians;Play;programs;Research;Research Personnel;responsible research conduct;Role;role model;Science;Scientist;statistics;Systems Biology;Training;transcriptomics;Universities;Washington;Woman

PROJECT_TITLE: Child Health Research Center


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The Molecular Basis of Pediatric Disease Training Program at UPMC Children’s Hospital of Pittsburgh supports the training of pediatric physician-scientists who plan careers dedicated to basic research. The broad public health significance of this program will be realized through the academic and scholarly accomplishments of the trainees, with connections to both the direct treatment of pediatric patients in the clinical setting and the discovery of basic disease mechanisms and new therapeutic agents.

PI_NAMEs: DERMODY, TERENCE S. (contact)

PROJECT_TERMS: Award;Biomedical Research;career;Child Health;Childhood;Dedications;Department chair;design;Disease;Environment;equity, diversity, and inclusion;experience;Faculty;faculty mentor;Fostering;Funding;Future;Goals;Grant;high standard;improved;Individual;innovation;K-Series Research Career Programs;Laboratories;Leadership;Mentors;Molecular;Outcome;pediatric department;Pediatric Hospitals;Pediatric Research;peer coaching;Physicians;programs;Publications;Reproducibility;Request for Proposals;Research;Research Personnel;Research Project Grants;Resources;Scholars Program;Scientific Inquiry;Scientist;Secure;senior faculty;square foot;Talents;Teacher Professional Development;Training;training opportunity;Training Programs;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Molecular Basis of Pediatric Disease


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE TAM receptors (Tyro3, Axl and Mer) are dysregulated in numerous diseases including cancer, autoimmune diseases, and diseases induced by chronic inflammation. They also play important regulatory roles in adult tissues, including maintenance of the vascular and immune systems, creating challenges to target them therapeutically. This study investigates TAM receptor self- association, and association with co-receptors. Information from these studies will guide understanding of how these receptors are activated, and will inform how to effectively correct aberrant TAM receptor activity in disease.

PI_NAMEs: STARBIRD, CHRYSTAL  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Adult;Affect;Apoptotic;Autoimmune Diseases;Binding;Biochemical;Biochemistry;Biological Process;biophysical analysis;biophysical techniques;Biophysics;Cancer Biology;Cardiovascular Diseases;career development;Cell membrane;Cell Surface Receptors;Cell Survival;Cells;Chronic;Clinical;Complex;Cytokine Receptors;Data;Development;dimer;Dimerization;Disease;Environment;Epidermal Growth Factor Receptor;equity, diversity, and inclusion;extracellular;Extracellular Domain;Family;Fibronectins;hereditary blindness;Homeostasis;Immune response;Immune system;improved;Infertility;Inflammation;Inflammatory Response;innovation;insight;interest;Investigation;Kinetics;Laboratories;Length;Ligand Binding;Ligands;Link;Maintenance;Malignant Neoplasms;Mediating;Membrane;Mentors;Mentorship;Microscopy;Modeling;Molecular;Molecular Conformation;Motility;Nature;novel therapeutics;Phosphorylation;Phosphotransferases;Play;Process;programs;Proliferating;receptor;Receptor Activation;Receptor Protein-Tyrosine Kinases;Receptor Signaling;receptor-mediated signaling;Regulation;Research;Resources;response;Role;Signal Pathway;Signal Transduction;skills;Structure;targeted treatment;Techniques;Testing;theories;Therapeutic;therapeutic target;Tissues;Training;Vascular System;Virus;Virus Diseases;Work

PROJECT_TITLE: The Structural Basis of TAM Receptor Oligomerizarion and Co-receptor Interactions

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE We aim to identify deficits in the receipt of guideline-indicated care among black patients with symptomatic peripheral artery disease (PAD). We further endeavour to identify the specific role of physician implicit bias in the delivery of symptomatic PAD-related care and to develop a systems-based intervention to address disparate care delivery. In successfully completing this project, we will have preliminary data to support the development of a full-scale, multi-site intervention.

PI_NAMEs: KALBAUGH, COREY ANDREW (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Abdominal Pain;acute care;Address;Advisory Committees;Affect;Amputation;Appendicitis;Area;Attenuated;Award;Biomedical Engineering;black patient;Black Populations;Black race;black women;Blood Vessels;Bypass;cancer care;cancer health disparity;Cardiovascular system;care delivery;care providers;career;career development;Caring;Clinical;clinical decision support;Data;Databases;Decision Making;design;Development;Diabetes Mellitus;Diagnosis;Diagnostic tests;Disparate;Disparity;disparity reduction;Doctor of Philosophy;Education;Educational workshop;Epidemiologic Methods;Epidemiologist;Epidemiology;epidemiology study;Event;experience;Funding;Future;Goals;Guidelines;Health;health equity;Health Services Accessibility;Healthcare;Implicit Association Test;implicit bias;improved;Inferior;innovation;Institution;International;Intervention;Intervention Studies;Ischemia;K-Series Research Career Programs;Limb structure;Link;Literature;Location;Measures;Medicine;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Midwestern United States;Morbidity - disease rate;mortality;North Carolina;Operative Surgical Procedures;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Pelvic Inflammatory Disease;Peripheral arterial disease;Persons;Pharmaceutical Preparations;Physician's Role;Physicians;pilot test;Procedures;professor;Provider;provider behavior;Quality of life;Race;racial bias;racial disparity;Recommendation;Recording of previous events;Registries;Research;Research Personnel;Research Project Grants;revascularization;Risk;Role;Sampling;Scholarship;Scientist;Severity of illness;Site;Smoking;Societies;success;successful intervention;support tools;Surgeon;surgery outcome;Surveys;symposium;System;tenure track;Test Result;Testing;therapy design;Training;treatment and outcome;Unconscious State;Universities;Work

PROJECT_TITLE: Understanding and Addressing Racial Disparities in Guideline-Indicated Management of Symptomatic Peripheral Artery Disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases

ORG_DEPT: PATHOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE With our new discovery of the formation of three major subsets of virus-specific CD8 T cells in response to chronic viral infection, the aim of the study is to further elucidate the cellular, molecular and genetic pathways that govern the heterogeneity in T cell exhaustion. Harnessing this knowledge, we further aim to redirect CD8 T cell differentiation to restore and enhance their antiviral function and simultaneously limit T cell exhaustion.

PI_NAMEs: CUI, WEIGUO  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Acetylation;acute infection;Adoptive Transfer;Affect;Antigens;antiviral immunity;ATAC-seq;Binding;Blocking Antibodies;cancer immunotherapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Chromatin;Chronic;chronic infection;Computer Analysis;cytokine;Cytokine Signaling;design;Development;Effector Cell;effector T cell;Enhancers;Epigenetic Process;exhaust;exhaustion;extracellular;Flow Cytometry;gene regulatory network;Genetic;Genetic Transcription;Goals;Heterogeneity;improved;Individual;Infection;Inflammatory;insight;Interferons;Interleukin-10;interleukin-21;Knowledge;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Mediating;Modeling;Molecular;Names;Pathway interactions;PD-1 blockade;Phenotype;Population;Process;progenitor;programmed cell death protein 1;receptor;Research;response;RNA Interference;self-renewal;Signal Transduction;single-cell RNA sequencing;Site;Solid;stem cell differentiation;stem cell population;success;Surface;synergism;T cell differentiation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Time;Viral;Viral Physiology;Virus;Virus Diseases

PROJECT_TITLE: Phenotypic, Functional and Transcriptional Heterogeneity in T Cell Exhaustion


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: Project Narrative Telomere dysfunction is a hallmark of human cancer. Telomere-repeats containing RNA (TERRA) is a key regulatory molecule of telomere homeostasis, providing a mechanism for telomere chromatin remodeling, DNA replication processivity, and homologous recombination repair. TERRA may also serve as a telomere damage stress response signal that can alarm immune cell inflammatory signaling. Investigation of TERRA will provide information on telomere maintenance in cancer and aging, and may provide new methods for early stage cancer diagnosis.

PI_NAMEs: LIEBERMAN, PAUL M. (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Aging;ATRX gene;Automobile Driving;Binding;biological adaptation to stress;cancer diagnosis;Cell Aging;Cells;Chromatin;chromatin remodeling;Chromatin Structure;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Data;DAXX gene;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Repair;Elements;Enhancers;Epigenetic Process;Evolution;exosome;extracellular;Family;Family member;Functional disorder;G-Quartets;Genetic;Genetic Recombination;Genetic Transcription;Genome;genome integrity;Histone H3.3;Histones;Homeostasis;homologous recombination;Human;Immune;Immune signaling;Inflammatory;insight;Investigation;Knock-in;Length;Maintenance;Malignant Neoplasms;Methods;Molecular;Molecular Conformation;Mutation;pathogen;Pathogenicity;Pathway interactions;Pattern;Pattern recognition receptor;pharmacologic;Process;recombinational repair;recruit;Regulation;replication stress;response;RNA;Role;senescence;Signal Transduction;Stress;Stress Response Signaling;Structure;Syndrome;telomere;telomere damage;telomere loss;Telomere Maintenance;TP53 gene;Transcript;Transcription Initiation;tumor microenvironment;Tumor Suppressor Proteins

PROJECT_TITLE: Role of TERRA in Telomere Maintenance and Telomere Stress Response

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]