NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: COLLEGE PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: The proposed research is relevant to public health because millions of older adults living in the United States experience decreased quality of life because of difficulty communicating, particularly in the common situation when there is background noise. This research aims to understand how age and hearing loss impacts spatial hearing, one major way the brain minimizes the effects of background noise on speech perception. Thus, the proposed research is relevant to the NIH mission to develop new knowledge and improve technologies to help treat disability and the NIDCD mission to provide technological interventions for hearing loss.

PI_NAMEs: GOUPELL, MATTHEW J. (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Age;age related;age related changes;Aging;Audiology;Auditory Brainstem Responses;Auditory Perception;Auditory Threshold;baby boomer;Behavioral;Binaural;binaural hearing;Brain;Caring;Clinical;cohort;Communication;Communication difficulty;Complex;Cues;Data;Data Set;disability;Ear;experience;Frequencies;Future;Generations;Goals;gradient boosting;Hearing;hearing impairment;Human;human old age (65+);improved;inclusion criteria;Individual;innovation;Intervention;Knowledge;large datasets;Learning;life span;Linear Models;Location;Machine Learning;machine learning method;Measurement;Methods;Mission;Modeling;National Institute on Deafness and Other Communication Disorders;neural;neural network;Noise;normal hearing;novel strategies;older adult;otoacoustic emission;Outcome;Participant;Perception;Peripheral;Persons;Public Health;Quality of life;racial diversity;random forest;Research;Research Design;Research Personnel;Sensory;sound;Speech;Speech Perception;support vector machine;System;Technology;technology intervention;temporal measurement;United States;United States National Institutes of Health;Validation

PROJECT_TITLE: Effects of asymmetries on binaural-hearing abilities across the lifespan

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The primary care setting has potential to connect patients with obesity and overweight to effective weight loss programs and tools. This study will test the effects of a primary care-situated intervention focused on motivating and guiding patients to use empirically supported online tools for goal setting and self monitoring, and online communities to support weight loss. The intervention was designed with implementation considerations in mind, and, if effective, has significant potential to be implemented within primary care practices to increase the number of adults with excess weight who achieve clinically meaningful weight loss.

PI_NAMEs: JAKE-SCHOFFMAN, DANIELLE ERIN (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Address;Adoption;Adult;African American;Appointment;Awareness;Behavior;behavior change;Black Populations;Body Weight decreased;Clinic;Clinical;clinical implementation;Cluster randomized trial;Communities;Complex;Credentialing;Data;design;Diet;Diet Monitoring;digital health;Eating;economic evaluation;Education;Effectiveness;effectiveness testing;effectiveness/implementation trial;Electronic Mail;Elements;Environmental Risk Factor;Evaluation;Feedback;flexibility;food surveillance;Future;future implementation;Goals;Health;Health behavior;implementation barriers;implementation trial;improved;Individual;Intervention;Interview;Latino Population;Low income;Maintenance;Measures;Mediating;Mediator;men;Methods;Mind;Modeling;Monitor;mortality;novel strategies;obese patients;Obesity;online community;Overweight;Patient Care;patient engagement;Patients;Physical activity;Pilot Projects;pilot test;population health;Primary Care;primary care clinic;primary care patient;primary care practice;primary care provider;primary care setting;primary outcome;Procedures;program costs;programs;psychosocial;Quality of life;Randomized;recruit;Research;Resources;Risk;Schedule;secondary outcome;Self Efficacy;Series;social;Speed;Structure;success;System;Testing;Text Messaging;theories;therapy design;Time;tool;Translational Research;trial design;trial planning;Underrepresented Populations;virtual;Visit;Weight;Weight Gain;weight loss intervention;weight loss program

PROJECT_TITLE: A hybrid effectiveness/ implementation trial using online tools to increase weight loss among primary care patients

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The overall goals of the parent project are to determine the impact of an implicit priming intervention, designed to alter food perceptions, on brain responses to food, food intake behaviors and weight-loss maintenance in individuals with overweight/obesity. The proposed supplement will add an assessment of early-life adversity to the parent project, to determine if early-life adversity impacts the neuronal response to food cues in brain regions involved in reward processing, and if this mediates effects of adversity on adiposity. This project will support research training for an incoming graduate student from a group underrepresented in health sciences.

PI_NAMEs: TREGELLAS, JASON R (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Acute;Affective;Behavior;Behavioral;Body Composition;Body Weight decreased;Brain;Brain region;Calories;career development;Cues;design;Doctor of Philosophy;early life adversity;Eating;Eating Behavior;energy balance;Energy Intake;Food;Food Preferences;Goals;graduate student;Health;Health Sciences;improved;Individual;Intervention;intervention effect;Maintenance;Measures;Mediating;Neurons;novel;Obesity;Overweight;parent grant;parent project;Parents;Perception;Predisposition;preference;prevent;Regulation;Research;Research Support;Research Training;response;reward processing;Risk;Strategic Planning;therapy design;Training;Underrepresented Populations;United States National Institutes of Health;Visual;Weight;weight maintenance

PROJECT_TITLE: Neuronal and behavioral effects of an implicit priming approach to improve eating behaviors in obesity: Diversity supplement.

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Per capita opioid consumption rates in the United States are the highest in the world, resulted in almost 500,000 deaths from 1999-2019, and are driven by prescribing and dispensing practices. There is limited evidence explaining how pharmaceutical companies influenced patients, health care providers, and regulators in the US to believe that opioids were safe and non-addictive, information that is needed to inform future regulatory actions and practice guidelines addressing other addictive pharmaceuticals.

PI_NAMEs: APOLLONIO, DOROTHY ELINOR (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: abuse liability;addiction;Address;Advertising;Advisory Committees;Advocacy;American;Archives;Area;Artificial Intelligence;Behavior;behavior influence;Benzodiazepines;Cannabis;Cessation of life;commercialization;Consumption;Coupled;Data;direct to consumer advertising;Drug Industry;Drug Prescriptions;ecstasy;Educational Materials;Ethics;Food;Fostering;Future;Government;Government Agencies;Guidelines;health determinants;Health Personnel;Industry;Influentials;innovation;interest;Knowledge;Letters;Librarians;Litigation;Lobbying;Manufacturer;Market Research;Marketing;Mediation;Medical;Medicine;Mental Health;Methamphetamine;Methods;novel;older adult;Opioid;opioid epidemic;opioid overuse;opioid use;opioid use disorder;outreach;overdose death;Oxycodone;Patients;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacologic Substance;Physicians;Policies;Policy Maker;Practice Guidelines;prescription opioid;prevent;Privatization;Process;Professional Organizations;Provider;Public Health;Regulation;Reporting;Research;Research Personnel;Risk;Role;Safety;Science;Shapes;Stigmatization;Strategic Planning;Testing;Therapeutic;Tobacco;Trust;Uninsured;United States;United States Food and Drug Administration;Vulnerable Populations;Work

PROJECT_TITLE: Using opioid industry documents to understand marketing of addictive medications

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Los Angeles

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE Acinetobacter baumannii, is one of the most threatening bacterial pathogens in large part due to its increasing resistance to antibiotics. Using a novel testing strategy, we have recently identified rifabutin as being highly active against this bacteria pathogen. Further characterization is needed to determine the efficacy of rifabutin in combination with other antibiotics.

PI_NAMEs: LUNA, BRIAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acinetobacter baumannii;Adopted;Adoption;Agar;antagonist;Antibiotic Resistance;Antibiotics;Biological;Biological Assay;Carbapenem-resistant Acinetobacter;Carrier Proteins;Cells;Clinical;clinical translation;Clinical Trials;Colistin;Combined Antibiotics;Data;Diffusion;Drug Combinations;Drug Kinetics;efficacy evaluation;efficacy study;Equus caballus;FDA approved;Fiber;Formulation;Goals;head-to-head comparison;Hyperactivity;improved;In Vitro;in vivo;Infection;interest;International;Iron;Lung infections;Measures;Methods;Modeling;mouse model;Mus;novel;Nutrient Depletion;pathogenic bacteria;Patients;Phase I Clinical Trials;Phase II Clinical Trials;pre-clinical;Predisposition;priority pathogen;Protocols documentation;Quality Control;Randomized Controlled Clinical Trials;resistance frequency;Rifabutin;Sepsis;Site;synergism;Test Result;Testing;Therapeutic;Time;Translations;trend;World Health Organization

PROJECT_TITLE: Identifying Synergistic Rifabutin-Containing Combinations Against A. baumannii

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Natural Products;Prevention

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Proposal Narrative The goal of this UG3/UH3 proposal is to discover and develop natural product compounds towards colorectal cancer (CRC) prevention/interception in individuals at high-risk for developing CRC. We will identify anticancer natural product compounds towards clinically relevant targets of CRC. These studies will provide non-toxic natural product compounds for future clinical use for prevention of cancer.

PI_NAMEs: RAO, CHINTHALAPALLY V. (contact)

PROGRAM_OFFICER_NAME: BISWAS, KAJAL

PROJECT_TERMS: adenoma;Adhesions;Animal Cancer Model;Anti-tumor Natural Products;Antineoplastic Agents;bioactive natural products;Biological Assay;cancer prevention;Carcinoma;cardiovascular risk factor;Cell Proliferation;Cell Survival;Cells;Clinic;Clinical;clinically relevant;Collaborations;Colon;Colorectal Cancer;colorectal cancer prevention;Development;Dinoprostone;Dose;efficacy evaluation;Eicosanoids;Epoprostenol;Evaluation;Future;Goals;Growth;high risk;Hydroxyeicosatetraenoic Acids;Immune Evasion;in vivo;Individual;inhibitor;Lead;Lesion;Leukotrienes;Libraries;Malignant Neoplasms;Mediator;Metabolism;Micro Electron Diffraction;Microsomes;National Center for Advancing Translational Sciences;Natural Compound;natural product derivative;Natural Products;neoplastic;neoplastic cell;Organoids;Ornithine Decarboxylase;overexpression;Pathway interactions;Phase;Play;Polyamines;Pre-Clinical Model;Prevention;Proliferating;Property;Prostaglandins;protein purification;Resources;Role;Sampling;scale up;screening;Signal Transduction;Specificity;Structure;synthetic drug;Technology Transfer;Testing;Therapeutic Intervention;thrombotic;tumor microenvironment;tumor progression;Tumor Promoters;tumorigenic;United States National Institutes of Health;Validation

PROJECT_TITLE: Discovery and Development of Natural Products for Interception of CRC

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (J1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: LIEBER INSTITUTE, INC.

ORG_STATE: MD

PHR: PROJECT NARRATIVE Dysregulation of the habenula, a key node of reward circuitry governing motivated behavior, is associated with addiction, but the molecular mechanisms mediating its role in substance use disorders are largely unknown. In this application, we will use single cell and spatial transcriptomic approaches to identify molecular changes associated with chronic opioid self-administration in cell types and projection neurons of the rodent habenula. Upon integration with human habenula data in the context of opioid use disorder, our study will help prioritize molecular pathways that can be targeted to advance cell type and circuit-specific therapeutics for the treatment of opioid addiction.

PI_NAMEs: MAYNARD, KRISTEN ROSE (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Acceleration;addiction;Address;Atlases;Autopsy;Award;Behavior;Brain;cell type;Cells;Chromium;Chronic;Clinical;connectome;Coupled;Data;Data Set;Development;differential expression;Fentanyl;Follow-Up Studies;Functional disorder;Funding;Future;Gene Expression;Genes;Genetic Transcription;Genomics;Glutamates;Habenula;Human;human data;Impairment;improved;Individual;insight;Label;Lateral;Ligands;Maps;Medial;Mediating;Mental disorders;Molecular;Molecular Genetics;Molecular Profiling;molecular subtypes;mortality;motivated behavior;Mus;National Institute of Drug Abuse;Neurons;new therapeutic target;novel;Nuclear;Opiate Addiction;Opioid;opioid epidemic;opioid exposure;opioid use;opioid use disorder;overdose death;Pathway interactions;Population;Predisposition;Prevention;Public Health;Publishing;Rattus;receptor;Resolution;Resources;response;reward circuitry;reward processing;Rewards;Rodent;Rodent Model;Role;Saline;Self Administration;single nucleus RNA-sequencing;single-cell RNA sequencing;Substance Use Disorder;substance use treatment;supervised learning;synthetic opioid;System;Techniques;Technology;Therapeutic;therapeutic development;transcriptome sequencing;transcriptomics;Translating;Ventral Tegmental Area

PROJECT_TITLE: Integrated single cell and spatial mapping of habenula circuitry to identify projection-specific molecular pathways associated with opioid exposure.

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Diabetes;Genetics;Kidney Disease

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease, but how diabetes leads to kidney damage is not well understood, and this has hindered the development of effective therapies for DN. This project investigates dynein-mediated mistrafficking in podocytes as a new mechanism of DN. By dissecting the process of dynein-driven pathogenesis, this work will identify a broad spectrum of potential new targets to guide a rational development of therapies and lead to better prognosis for patients with DN.

PI_NAMEs: SUN, HUA  (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Affect;Attenuated;Binding;Biological Assay;Cells;Coupled;Data;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Nephropathy;Dynein ATPase;effective therapy;End stage renal failure;Epigenetic Process;Event;Family;Functional disorder;Genes;Genetic Transcription;glomerular filtration;Goals;Hyperglycemia;In Vitro;in vivo;in vivo Model;Injury;Knock-out;Knowledge;live cell imaging;Lysosomes;Mediating;Metabolism;Modeling;Modification;molecular sieving;Morbidity - disease rate;mortality;Motor;mouse model;multicatalytic endopeptidase complex;Mus;nephrin;novel therapeutics;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;patient prognosis;Persons;Phosphotransferases;Physiologic pulse;podocyte;Post Translational Modification Analysis;Post-Translational Protein Processing;prevent;Process;promoter;protective effect;protein complex;protein degradation;protein protein interaction;protein transport;Proteins;proteostasis;recruit;Recycling;Regulation;renal damage;Renal glomerular disease;Reporter Genes;Role;sensor;Severities;Signal Transduction;slit diaphragm;Sorting;Streptozocin;Stress;Testing;therapy development;trafficking;transcription factor;Transgenic Mice;Ubiquitin;Ubiquitination;United States;Up-Regulation;Work

PROJECT_TITLE: Targeting dynein-mediated trafficking in diabetic podocytopathy

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative Statement Stanford University and the SLAC National Accelerator Laboratory propose to operate a National Cryogenic Electron Microscopy (cryoEM) Center, providing free access to state-of-the-art instruments for atomic resolution structure determination in foundational biology and human health research. Additionally, the Center will focus on optimizing the vitrification process for high- resolution data collection from biochemically purified samples. Through a comprehensive training program, we aim to empower scientists from diverse institutions, fostering their independence as cryoEM investigators and disseminating cryoEM technology to traditionally under-resourced research institutions.

PI_NAMEs: CHIU, WAH  (contact);HEDMAN, BRITT ;SCHMID, MICHAEL F.

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TITLE: The Stanford-SLAC CryoEM Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-P (50)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: NARRATIVE This work will examine how Drosophila melanogaster larvae control their body temperature (thermoregulate) by integrating interoceptive sensory inputs from internal and peripheral thermosensors. This work will provide fundamental insights (at the molecular, cellular and circuit levels) into how nervous systems process sensory input to control behavior and physiology, a topic important for human physiology and disease processes.

PI_NAMEs: GARRITY, PAUL  (contact);SAMUEL, ARAVINTHAN D.

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Animals;Automobile Driving;Behavior;Behavior Control;Behavioral;behavioral response;Body Temperature;Brain;Brain region;Cations;Cells;Clothing;Collaborations;Computer Models;connectome;control theory;Data;Decision Making;Disease;Dorsal;Drosophila genus;Drosophila melanogaster;Ensure;Environment;Exhibits;feeding;Foundations;Genetic;genetic manipulation;Goals;Homeostasis;Human;Hunger;in vivo imaging;Individual;insight;Interoception;Investigation;Label;Larva;larval control;Lateral;Maps;Mediating;Modeling;Molecular;Molecular Genetics;Monitor;Nervous System;Neurons;neurophysiology;Neurosciences;Optics;Organ;Pathway interactions;Peripheral;Physiologic Thermoregulation;Physiological;Physiology;Process;Property;Publications;Reagent;receptor;Research Personnel;response;sensor;Sensory;sensory input;sensory integration;Sensory Process;Shapes;Shivering;Signal Transduction;Site;skills;Stereotyped Behavior;Stream;success;Sweating;System;Temperature;Temperature Sense;Tissues;transmission process;TRPA channel;United States National Institutes of Health;Work

PROJECT_TITLE: Molecular and cellular determinants of Drosophila larva thermotaxis

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative During early postnatal life our brains are molded by experience, and exposure to adverse environments disrupts normal development often in an irreversible fashion. We use the visual cortex as model for examining how the precise circuitry of the cortex is shaped by experience. Understanding how this process is regulated will provide invaluable insights into how the early brain remains flexible and it will contribute to the development of effective therapeutic approaches to restore flexibility to aging or damaged brains.

PI_NAMEs: TRACHTENBERG, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: 3-Dimensional;Adult;Age;Aging;Animals;area striata;Attention;Automobile Driving;awake;Axon;Binocular Vision;Brain;Brain Injuries;Calcium;cell type;Cells;Complex;Contralateral;Darkness;Data;Dependence;Development;developmental disease;Disparity;Electrophysiology (science);Environment;Etiology;excitatory neuron;experience;Exposure to;Eye;fascinate;flexibility;Goals;Head;hippocampal pyramidal neuron;Image;improved;Individual;inhibitory neuron;insight;Interneurons;Investigation;Ipsilateral;Label;Life;Measurement;Measures;Mediating;Modeling;Molds;Mus;neural circuit;neuroimaging;Neurons;new technology;nonhuman primate;novel;orientation selectivity;Phase;Photic Stimulation;Play;postnatal;Process;Property;receptive field;recruit;response;Role;Series;Shapes;Signal Transduction;Somatostatin;spatial integration;Structure;technology development;Testing;Thalamic structure;therapeutically effective;Time;Track and Field;transcriptomics;two-photon;Vision;Visit;Visual;Visual Cortex;Visual Pathways;visual processing

PROJECT_TITLE: Origins of plasticity in the establishment of binocular vision

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

PHR: Project Narrative Reliable, reproducible, annual estimates of the costs of Alzheimer’s disease (AD) and AD related dementias (ADRD) are critical for stakeholders and decision makers to fully understand the size of the economic and financial disease burden and to inform priority setting. Current estimates of dementia costs in the U.S. are based on a limited set of costs. We propose to provide national, annual, comprehensive cost of dementia estimates using the best data sources available and to build the research infrastructure to greatly increase national research capacity for generating cost estimates and for utilizing innovative simulation methods for analyzing what impacts these costs, how and for whom.

PI_NAMEs: GOLDMAN, DANA P;ZISSIMOPOULOS, JULIE M (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Academia;Adult;Alzheimer's Disease;Alzheimer's disease related dementia;burden of illness;Caregivers;caregiving;Caring;Clinical Trials;Code;Communication;Communities;cost;cost estimate;cost of dementia;Data;data platform;Data Set;Data Sources;Dementia;dementia care;Dementia caregivers;demographics;Development;Disease;economic impact;Economics;Educational workshop;Elderly;Ensure;experience;Facilities and Administrative Costs;Family;financial exploitation;Friends;Future;Goals;Health;Health Care Sector;improved;Income;Infrastructure;innovation;insight;Institution;Intervention Trial;Investigator-Initiated Research;Investments;Knowledge;Leadership;Lived experience;Medical Care Costs;Mentors;Mentorship;Methods;middle age;Modeling;models and simulation;Monitor;multidisciplinary;novel;outreach;Pennsylvania;Persons;physical abuse;Pilot Projects;Policies;population health;Population Projection;Privatization;productivity loss;programs;Public Health;Quality of life;Reproducibility;Reproducibility of Results;Research;Research Infrastructure;Research Project Grants;Resources;Schools;Science;Services;simulation;societal costs;Specialist;Structure;Support System;Surveys;System;Time;tool;United States;Universities;Update;Variant;Work;Workplace

PROJECT_TITLE: The United States Cost of Dementia Model: Quantifying Current and Future Impacts of Alzheimer’s Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-R (J2)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: AMES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: IOWA STATE UNIVERSITY

PHR: PROJECT NARRATIVE RNA plays many key roles in human biology and health, such as gene expression regulation and splicing. Modulation of these biological functions can have a major global impact, as was sharply demonstrated during the COVID-19 pandemic—where both the cause and treatment of this disease involved RNA. Every aspect of RNA biology is guided by molecular structure, yet the identification of functional RNA structures remains frustratingly difficult, inhibiting efforts to understand and treat a wide array of diseases. This project advances an innovative and robust approach for discovering RNA structure that will be used to identify novel, potentially druggable, RNA structures in viral genomes.

PI_NAMEs: MOSS, WALTER  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Address;Base Pairing;Basic Science;Binding;Biochemical;Bioinformatics;Biological;Biological Assay;Biological Process;Biology;biophysical analysis;biophysical properties;Biophysics;Cells;Chemicals;comparative;Complex;Consensus;COVID-19 pandemic;Cryoelectron Microscopy;Data;Development;Disease;disorder prevention;Drug Design;drug discovery;Drug Targeting;Elements;Emerging Technologies;Frustration;Funding;Future;Gene Chips;Gene Expression Regulation;Generations;Genome;Goals;Gold;Grain;Health;Human;Human Biology;Human Herpesvirus 4;human pathogen;improved;in silico;In Vitro;in vivo;Influenza A virus;innovation;insight;interest;Knowledge;Location;Luciferases;Medical;Methodology;Methods;Modeling;Molecular Structure;novel;novel therapeutics;Outcome;particle;pathogenic virus;Pathogenicity;Phylogenetic Analysis;Play;Process;programs;Property;Research;Resolution;RNA;RNA Binding;RNA Folding;RNA Splicing;RNA-targeting therapy;Scanning;Selection Criteria;small molecule;Speed;structural biology;Structural Models;Structure;Testing;Therapeutic;Therapeutic Agents;therapeutic RNA;therapeutic target;Thermodynamics;three dimensional structure;three-dimensional modeling;tool;Untranslated RNA;Viral;Viral Genome;viral RNA;virtual screening;Virus;Work

PROJECT_TITLE: Finding and folding novel RNA structures

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Microbiome;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Despite demonstrated association between tissue resident microbiota, a collection of microbes living in association with the body, and mucosal barrier homeostasis in many organ systems, little is known in the larynx, especially regarding bacterial contribution to the healing process of mucosal wound, a hallmark of various voice disorders that have devastating impact on communication, job performance, and quality of life. The goal of this proposal is to investigate the influence of resident bacteria on acute wound healing of laryngeal mucosa. Results will provide specific guidance into understanding the mechanisms of immune system regulation by resident microbiota in laryngeal health and disease and are essential in developing new therapies that promote mucosal healing.

PI_NAMEs: AN, RAN  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: acute wound;Affect;American;Animals;Antibiotic Therapy;Automobile Driving;Bacteria;Bacteriology;Body part;Body System;Cell Differentiation process;cell motility;cell type;Cells;Cicatrix;Collection;Communication;Communication impairment;Complex;Data;Disease;dysbiosis;Dysphonia;Endothelial Cells;Epithelial Cells;epithelial injury;epithelial repair;epithelial wound;Epithelium;epithelium regeneration;Etiology;Excision;Exposure to;Fibroblasts;functional group;Gene Expression;Genes;Germ-Free;Gnotobiotic;Goals;healing;Health;Homeostasis;host microbiome;host microbiota;host-microbe interactions;Human;Immune;Immune response;Immune system;Immunity;Immunoglobulin A;Immunology;improved;Infection;Inflammation;Inflammatory;inflammatory marker;injured;Injury;injury and repair;innovation;Knowledge;Lamina Propria;Laryngeal Diseases;Laryngeal Epithelium;Laryngeal Injury;Laryngeal Mucosa;Larynx;Longitudinal Studies;Macrophage;Maintenance;Mature T-Lymphocyte;Measures;Mechanics;Methods;Microbe;microbial;microbial community;microbiome;microbiome research;microbiota;migration;model organism;Modeling;Molecular;Mucositis;Mucous body substance;Mucous Membrane;Mus;Naphthalene;Natural regeneration;neutrophil;novel;novel therapeutics;Operative Surgical Procedures;Organ;Outcome;Pathogenicity;Performance at work;Plasma Cells;Play;Prevention;Prevention strategy;probiotic therapy;Process;programs;Proliferating;protein expression;Quality of life;Radiation;Regulation;repaired;Research;response;Role;Secondary to;Shapes;social communication;Stratified Squamous Epithelium;Structure;System;Time;tissue injury;Tissues;treatment strategy;vocal cord;vocalis muscle;Voice Disorders;Work;wound;wound healing

PROJECT_TITLE: Microbial modulation of mucosal wound healing in the larynx

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Autoimmune Disease;Congenital Structural Anomalies;Diabetes;Immunotherapy;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: PROJECT NARRATIVE Although islet transplantation can provide a functional cure for insulin-dependent diabetes, a growing public health problem, primary islet shortage limits therapeutic application. Understanding the molecular basis of functional maturation and immune-evasion is crucial to generate fully mature immunoprotected human islets from pluripotent stem cells in vitro. The proposed research focuses on technology designed to develop selective, mass produced, immune evasive functional human islets with a safety-guard system.

PI_NAMEs: YOSHIHARA, EIJI  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: 3-Dimensional;absorption;Address;Adult;Allogenic;allograft rejection;Autoimmune;Autologous;Beta Cell;Blood Glucose;blood glucose regulation;Cadaver;CD34 gene;Cell Therapy;Cells;cost effective;Cytoprotection;design;Detection;Diabetes Mellitus;diabetes mellitus therapy;diabetes pathogenesis;diabetic;Diabetic mouse;efficacy evaluation;Endocrine;Engineering;Functional disorder;Generations;Genetic;Giant Cells;Glucose;glucose monitor;glycemic control;Goals;Graft Rejection;Heterogeneity;HLA-A gene;HLA-C Antigens;Hormone secretion;Human;human induced pluripotent stem cells;human pluripotent stem cell;Hyperactivity;Immune;immune checkpoint;Immune Evasion;Immune response;Immunocompetent;immunoreaction;immunoregulation;Immunosuppression;Immunosuppressive Agents;improved;In Vitro;in vivo;in vivo Model;innovation;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;Ion Transport;islet;Islet Cell;islet stem cells;Islets of Langerhans;Islets of Langerhans Transplantation;Laboratories;large scale production;Lipids;Mediating;Methods;Minerals;Modeling;Molecular;mouse model;Mus;new technology;NOD/SCID mouse;novel;novel marker;Organogenesis;Organoids;overexpression;Pathway interactions;Patients;Physiological;Pluripotent Stem Cells;prevent;Production;progenitor;programmed cell death ligand 1;promoter;Protocols documentation;Public Health;Quality Control;Reaction;Regulation;Reporter;Reproducibility;Research;Research Proposals;response;Role;Safety;screening;Source;spatiotemporal;stem cells;Streptozocin;success;System;Technology;Testing;Therapeutic;Tissue Engineering;transcriptome;transcriptomics;translational goal;Translational Research;Transplantation;transplantation therapy;Work

PROJECT_TITLE: Spatiotemporal regulation of human islet organogenesis

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE Oregon Health and Science University (OHSU) and the Pacific Northwest National Laboratory (PNNL) will continue to operate a user-oriented, state-of-the-art national center for cryo-electron microscopy designated as the Pacific Northwest Center for Cryo-EM (PNCC). The PNCC will enable users from diverse biomedical disciplines in the effort of elucidating the structures of biological molecules and macromolecular complexes using high-resolution cryo-EM, and it will bring new scientists into this field by providing education in the theory and practice of this enabling technology to help build a diverse workforce in the applications of cryo-EM.

PI_NAMEs: EVANS, JAMES E;GOUAUX, JAMES E;REICHOW, STEPHEN LOEN (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;Adopted;Artificial Intelligence;Automation;Basic Science;Biological;biological systems;Biomedical Research;California;Communities;community engagement;complex biological systems;Computational algorithm;Cryoelectron Microscopy;Data;Data Analyses;Data Collection;data management;Dedications;Democracy;design;Development;Discipline;Diverse Workforce;Drug Industry;Education;empowerment;Ensure;Equity;experience;Feedback;Funding;Future;Geography;Goals;Growth;Health;High Performance Computing;improved;Infrastructure;innovation;Institution;instrument;instrumentation;Investments;Laboratories;Leadership;Machine Learning;Macromolecular Complexes;meetings;member;Methods;Mission;Molecular Biology;New York;next generation;operation;Oregon;outreach;Pacific Northwest;particle;Pathway interactions;Play;Policies;Positioning Attribute;Preparation;Process;quality assurance;Reaction;Research;Research Personnel;Resolution;Resource-limited setting;Resources;response;Role;Sampling;Science;Scientist;screening services;Service provision;Services;Site;Specimen;structural biology;Structure;success;System;Techniques;Technology;theories;Time;Trainers Training;Training;Training Activity;training opportunity;Training Programs;underserved community;Underserved Population;United States National Institutes of Health;Universities

PROJECT_TITLE: Pacific Northwest Center for Cryo-EM


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: Jupiter

ORG_NAME: MAX PLANCK FLORIDA CORPORATION

PHR: To enable studies of how neuromodulators interact to control brain states and behavior, we propose a multi-disciplinary collaboration that emphasizes indicator optimization, in vivo characterization, and data sharing. Success of this team project will enable previously inaccessible measurements of the dynamic relationship between diverse molecular inputs and circuit dynamics in the mammalian brain, which are needed to understand brain function and behavior in health and disease.

PI_NAMEs: LIN, MICHAEL Z.;PODGORSKI, KASPAR ;SVOBODA, KAREL ;TIAN, LIN  (contact)

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: Acceleration;Acetylcholine;Address;Adoption;Algorithms;Anatomy;Area;Behavior;Behavioral;Benchmarking;Brain;brain control;Brain region;Calibration;Capsid;Catalogs;cell type;Chemicals;Collaborations;Color;Communication;Communities;Computer Models;Data;data science resource;Data Set;data sharing;design;Diffusion;Directed Molecular Evolution;Disease;Engineering;Ensure;environmental change;experimental study;Fiber;flexibility;Foundations;Funding;gamma-Aminobutyric Acid;Glutamates;Goals;Health;Image;In Vitro;in vivo;in vivo evaluation;Individual;information processing;Institution;Interdisciplinary Study;Knowledge;Link;Location;Logic;Machine Learning;Measurement;Measures;Membrane;Microscopy;Molecular;multidisciplinary;Mus;neural;neural circuit;neurochemistry;Neuromodulator;Neurons;neuroregulation;Neurosciences;neurotransmission;Neurotransmitters;Norepinephrine;Optics;optogenetics;Output;Pattern;Performance;Photometry;postsynaptic;Process;programs;promoter;Protocols documentation;rational design;Reagent;receptor;Regulatory Element;Reporter Genes;Reproducibility;Research;Research Personnel;Resolution;response;sensor;Serotonin;Shapes;Signal Transduction;Specificity;Speed;Structure;success;Synapses;System;Technology;temporal measurement;Testing;theories;tool;Transgenic Organisms;two-photon;United States National Institutes of Health;Validation;Variant;Viral;voltage;web portal

PROJECT_TITLE: Optimization of genetically encoded voltage and neurotransmitter indicators for multiwavelength in vivo analysis of brain circuits

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (02)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Natural Products;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Enhanced ribosome biogenesis and protein synthesis drives cell overgrowth and cancer. Methods to attenuate protein product could prevent the very earliest steps of tumor formation. Through this proposed project, we seek to use two novel platforms to identify and characterize natural products that reset protein synthesis levels back to normal levels in diseased cells.

PI_NAMEs: BUSZCZAK, MICHAEL  (contact);TAGLIABRACCI, VINCENT SCOTT

PROJECT_TERMS: anti-cancer research;Antineoplastic Agents;Attenuated;Back;Biogenesis;Biological Assay;cancer cell;cancer initiation;cancer prevention;cell immortalization;Cell Nucleolus;Cell Physiology;Cell Proliferation;cell transformation;Cells;cellular targeting;Collection;Data;Development;Disease;DNA Polymerase I;Dose;effectiveness testing;Exhibits;experimental study;Follow-Up Studies;Genes;Genetic Transcription;Goals;Growth;Hypertrophy;In Vitro;in vivo;in vivo Model;inhibitor;innovation;innovative technologies;Lead;Libraries;Link;liver cancer model;liver cancer patient;liver cancer prevention;Liver diseases;Liver neoplasms;Malignant neoplasm of liver;Malignant Neoplasms;Methods;Molecular Machines;mouse model;Mus;National Cancer Institute;Natural Compound;Natural Products;Nature;novel;novel therapeutics;Oncogenes;Pharmaceutical Preparations;Phase;Play;Positioning Attribute;Pre-Clinical Model;prevent;Prevention;Primary carcinoma of the liver cells;Production;Proliferating;Protein Biosynthesis;Protein Synthesis Inhibition;Proteins;Reporter;Resolution;Ribosomal Biogenesis Pathway;Ribosomal RNA;Ribosomes;Role;screening;small molecule;small molecule inhibitor;System;Technology;Testing;Therapeutic;Therapeutic Index;tool;Toxicology;tumor;tumor progression;tumorigenesis

PROJECT_TITLE: Developing ribosome biogenesis inhibitors for the prevention of cancer


ADMINISTERING_IC: OH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: SIMPSON, CHRISTOPHER D (contact)

PROJECT_TITLE: OCCUPATIONAL SAFETY AND HEALTH EDUCATION AND RESEARCH CENTERS (T42)


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PI_NAMEs: HARRIS ADAMSON, CARISA  (contact)


ORG_CITY: HARTFORD

ORG_NAME: CONNECTICUT STATE DEPT OF PUBLIC HEALTH

ORG_STATE: CT

PHR: Project Narrative The objectives and strategic aims for this cooperative agreement funding cycle were developed in recognition of the current occupational health surveillance capacity as well as goals from NIOSH’s National Occupational Research Agenda (NORA), and the National Academy of Sciences, Engineering and Medicine’s 2018 surveillance recommendations. The Specific Aims of the proposed Program, including three projects focused on Fundamental occupational health surveillance activities as well as two separate Fundamental-Plus projects focused on in-depth and follow-back investigation and assessment as well as development, implementation, and evaluation of public health policies in targeted workplaces, were developed to continue to expand capacity for occupational illness and injury surveillance at the Connecticut Department of Public Health and to maintain continuity in our surveillance and intervention programs for the duration of the project period. These programs and the staff they support provide the basis for the protection of worker health in our state, not only through surveillance and intervention activities but also through the generation of ideas for how to make our program activities more efficient, effective, and beneficial to the Connecticut workforce..

PI_NAMEs: ST. LOUIS, THOMAS E (contact)

PROGRAM_OFFICER_NAME: O'NEILL, EDUARDO

PROJECT_TITLE: Occupational Health Fundamental-Plus Surveillance Program in Connecticut - IRB Approval and Human Subjects Training Certifications


ORG_CITY: Atlanta

ORG_NAME: GEORGIA STATE DEPARTMENTOF PUBLIC HEALTH

ORG_STATE: GA

PHR: Project Narrative The Georgia Department of Public Health Occupational Safety and Health Surveillance Program (GA-OHS) proposes is to strengthen its current occupational safety and health surveillance and build upon its capacity by establishing a Fundamental-Plus Program. GA-OHS will continue to systematically collect, analyze, interpret, and disseminate data on the state employment profile and the 24 OHIs that have been recommended by the National Institute for Occupational Safety and Health (NIOSH) and the Council of State and Territorial Epidemiologists (CSTE). GA-OHS will conduct in-depth analyses and surveillance of OHIs with rates that have increased over time. Georgia OHIs priority and emerging conditions include work-related transportation incidents, work-related pesticide associated illness and injury, and work-related COVID-19.

PI_NAMEs: BAYAKLY, A. RANA (contact)

PROJECT_TITLE: Georgia Occupational Health Surveillance Program


ORG_CITY: NASHVILLE

ORG_NAME: TENNESSEE STATE DEPARTMENT OF HEALTH

ORG_STATE: TN

PHR: TN Occupational Health Surveillance Program PAR-20-312 PROJECT NARRATIVE (limit 3 sentences) The Tennessee Occupational Health and Safety Surveillance Program provides fundamental information about the occurrence of work-related injuries and illness. By doing so the program aims to guide policy, affect research, and help interventions, in order to improve the health and safety of Tennessee workers.

PI_NAMEs: CRUMPLER, BENJAMIN  (contact)


ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PI_NAMEs: DAVIS, KERMIT G. (contact)

PROJECT_TITLE: Education and Research Center (ERC - Cincinnati)


ORG_CITY: HARRISBURG

ORG_NAME: PENNSYLVANIA STATE DEPT OF HEALTH

ORG_STATE: PA

PHR: Project Narrative Pennsylvania seeks to establish an Occupational Safety and Health Surveillance (PennOSHS) program filling a much needed gap to collect, analyze, interpret, and disseminate data related to workers and worker health while simultaneously identifying and engaging a diverse group of partners and stakeholders. The ultimate goal of the program is to contribute to reducing occupational morbidity/mortality and occupational health disparities in Pennsylvania. As the fifth most populous state in the nation, PennOSHS will also contribute significantly to the national occupational health surveillance system, especially in the area of work-related lead exposure, as Pennsylvania has one of the highest burdens of elevated adult blood levels in the nation.

PI_NAMEs: NAIR, ANIL  (contact)

PROJECT_TITLE: Pennsylvania Occupational Safety and Health Surveillance Program (PennOSHS)


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Through this expanded project, we aim to improve occupational surveillance and public health practice in Illinois by strategically linking surveillance data, work practices and enforcement activities through a network of occupational health stakeholders. These activities are integral to understanding, highlighting, and proactively preventing injuries and illnesses caused by chronic and emerging hazards at work. While the goal of our surveillance program is to improve health and safety across the entire workforce, we continue to focus on issues affecting the most vulnerable workers in Illinois and underserved populations.

PI_NAMEs: FRIEDMAN, LEE SCOTT (contact)

PROJECT_TITLE: Illinois Occupational Surveillance Program


ORG_CITY: HELENA

ORG_NAME: MONTANA DEPARTMENT OF LABOR AND INDUSTRY

ORG_STATE: MT

PHR: Montana Department of Labor and Industry Montana Occupational Health & Safety Surveillance (MOHSS) PAR-20-312 Project Narrative Montana consistently has one of the highest incidence rates of occupational injuries and illnesses in the country. The Montana Occupational Health and Safety Surveillance (MOHSS) program allows for closer inspection of the causes of these high rates through the use of public health surveillance. Findings from the program are communicated to stakeholders to allow for improvements to be made.

PI_NAMEs: BENDER, AARON MATTHEW (contact)

PROJECT_TITLE: Montana Occupational Health and Safety Surveillance Program


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PUBLIC HEALTH RELEVANCE: The MCOHS ERC serves the region of Minnesota, Wisconsin, North Dakota, and South Dakota and is a resource for industry, labor, federal, state, and local government agencies, agriculture, and numerous other partners. Recognized regionally, nationally, and internationally, it provides outstanding academic and research training programs and innovative Continuing Education programs to ensure the Center is positioned to continue to produce leaders who make important contributions to occupational safety and health.

PI_NAMEs: ARNOLD, SUSAN  (contact)


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Diabetes;Dietary Supplements;Microbiome;Nutrition;Pediatric;Prevention

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Increasing our understanding on how beneficial microbes and their components influence disease prevention or development will have a significant impact on human health. In this proposal, we seek to use a beneficial microorganism as a new strategy to prevent and/or ameliorate symptoms associated with the onset of type 1 diabetes.

PI_NAMEs: LORCA, GRACIELA L (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Adult;Adverse effects;aged;Animals;associated symptom;Autoimmunity;Bacteria;beneficial microorganism;Beta Cell;Bifidobacterium;Biological Assay;Blood;C-Peptide;CD8-Positive T-Lymphocytes;Cell Line;Cell Physiology;cell type;Cells;Child;Circulation;Consumption;Culture-independent methods;cytokine;Data;Development;Diabetes Mellitus;Diabetes prevention;dietary supplements;Disease Progression;disorder prevention;Distant;Double-Blind Method;dysbiosis;Environment;Epithelium;Evaluation;extracellular;Extracellular Structure;Frequencies;Genetic;Genetic Predisposition to Disease;Goals;gut microbiota;Health;Health Status;host-microbe interactions;Human;illness length;Immune;immune activation;Immune response;Immune system;Immune Tolerance;Immunity;Immunophenotyping;Incidence;Individual;Induction of Apoptosis;Inflammatory;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Intake;Intervention Studies;intestinal epithelium;Intestines;Knowledge;Kynurenine;Lactobacillus;Location;Mediating;Mediator;member;Methods;microbial;microbiota;microorganism;migration;monocyte;nanovesicle;Natural Killer Cells;peripheral blood;Pilot Projects;Population;preservation;prevent;Prevention;Prevention trial;Probiotics;randomized, clinical trials;Rattus;reduce symptoms;Research;Residual state;Resistance;response;Risk;Risk Factors;Rodent;Rodent Model;Role;Safety;safety and feasibility;safety testing;Sampling;secondary outcome;Serum;Signal Transduction;Site;stool sample;Stream;Supplementation;T-Lymphocyte Subsets;Translating;Tryptophan

PROJECT_TITLE: Evaluation of safety, tolerability and immunological responses to Lactobacillus johnsonii N6.2 supplementation in adults with Diabetes type 1


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: MILWAUKEE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MARQUETTE UNIVERSITY

PHR: PROJECT NARRATIVE The incidence of reported heroin use and nonmedical prescription opioid use is on the rise in recent years, with the rate of abuse in women increasing to a greater extent. The proposed studies will use a variety of techniques to identify how opioids disrupt function of brain regions responsible for cognitive flexibility and control over drug seeking behavior to identify substrates for the transition to opioid addiction and how factors such as biological sex influence development of these functional adaptations.

PI_NAMEs: HEARING, MATTHEW CARL (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: addiction;Attention;Behavior;Behavioral;biological sex;Brain region;cell type;clinically relevant;Cognitive;cognitive function;Contralateral;Corpus striatum structure;Data;Decision Making;Dependence;Development;Dopamine;Drug Modelings;drug seeking behavior;Drug usage;Electrophysiology (science);Exposure to;Female;flexibility;frontal lobe;functional adaptation;Functional disorder;Genetic;genetic manipulation;glutamatergic signaling;heroin use;hippocampal pyramidal neuron;Image;Impaired cognition;Impairment;in vivo;Incidence;Individual;individual variation;individualized medicine;information processing;insight;Intervention;Label;male;Measures;Medial;Modeling;Modification;Motivation;Nature;neural;neuroadaptation;Neurologic;neuromechanism;neuronal circuitry;Neurons;novel;Opiate Addiction;Opioid;opioid use;opioid use disorder;optogenetics;Output;Pain management;Pathway interactions;Pattern;Pharmaceutical Preparations;Physiological;Physiology;Pilot Projects;Play;Prefrontal Cortex;prescription opioid misuse;Preventive measure;psychologic;Publishing;receptor;Regulation;remifentanil;Reporting;resilience;Risk;Role;Self Administration;sex;Slice;Synapses;Techniques;Testing;Time;timeline;Transgenic Mice;Viral;Woman

PROJECT_TITLE: Opioid-induced dysregulation of cortico-striatal circuits


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative We propose to design DNA nanostructures that can present 2-3 protein/peptide ligands in three-dimensional space in a way that allows them to bind tightly to a protein. Our method will create synthetic blocking structures without having to target the protein interface, and enable detailed study or imaging/targeting of protein-protein interactions implicated in many aspects of health and disease.

PI_NAMEs: STEPHANOPOULOS, NICHOLAS  (contact);SULC, PETR

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: 3-Dimensional;ACE2;Affinity;Algorithms;Antibodies;Basic Science;Beds;Binding;Binding Proteins;Binding Sites;Biological;Biology;Blocking Antibodies;Coagulation Process;Computer Simulation;Cyclic Peptides;design;Disease;DNA;DNA Structure;Docking;Evolution;Feedback;Fibrin;Fibrinogen;flexibility;Geometry;Grain;Health;hybrid protein;Image;imaging agent;Immobilization;in silico;Individual;Libraries;Ligand Binding;Ligands;Light;Literature;Location;Measures;Membrane Proteins;Methods;Molecular;monomer;Multiprotein Complexes;mutant;Mutate;Mutation;nano;nanobodies;nanoscale;Nanostructures;neutralizing antibody;next generation;novel;novel therapeutics;Peptides;Phage Display;polymerization;Polymers;polypeptide;Positioning Attribute;Process;process optimization;protein complex;Protein Engineering;protein protein interaction;Proteins;receptor;Reporting;SARS-CoV-2 inhibitor;SARS-CoV-2 spike protein;scaffold;Series;Shapes;simulation;Site;small molecule;Specificity;Structure;Surface;synthetic antibodies;System;targeted agent;Testing;Translations;Variant;Work

PROJECT_TITLE: Multivalent protein-DNA nanostructures as synthetic blocking antibodies

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Neurosciences;Prevention

ORG_CITY: VERMILLION

ORG_NAME: UNIVERSITY OF SOUTH DAKOTA

ORG_STATE: SD

PHR: Project Narrative The roles of brain derived neurotrophic factor (BDNF) and its precursor proBDNF in the central nervous system have been shown to play major roles in health and disease, however, their roles in skeletal muscle tissues have yet to be determined. The proposed work aims to investigate the role of skeletal muscle-derived proBDNF on its receptor p75NTR in the endothelial cells of the microvasculature in skeletal muscle in ischemia-reperfusion injury. Determining the role of the proBDNF-p75NTR signaling pathway will lead to therapeutic targets to help treat and prevent ischemia-reperfusion injuries in patients.

PI_NAMEs: ABY, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Amputation;Apoptosis;Attenuated;Binding Proteins;Biomedical Research;Blood flow;blood perfusion;Brain;Brain-Derived Neurotrophic Factor;brain-derived neurotrophic factor precursor;C57BL/6 Mouse;career;Cell Adhesion Molecules;cell injury;Central Nervous System;Communication;Contralateral;Cyclic AMP-Dependent Protein Kinases;Data;Data Analyses;disability;Disease;Doctor of Philosophy;Endothelial Cells;endothelial dysfunction;Endothelium;Equipment;Event;experience;Experimental Designs;experimental study;extracellular;Extracellular Domain;Functional disorder;Growth;Health;Impairment;improved;In Vitro;in vivo;Induced Neurons;Inflammation;injured;Injury;Ischemia;Knock-out;Knowledge;Learning;Ligation;limb ischemia;Limb structure;Mediating;Mentors;Metabolism;Modeling;Mus;Muscle;Muscle function;neuroinflammation;neuron loss;neuroprotection;Neurotrophic Tyrosine Kinase Receptor Type 2;new therapeutic target;NGFR Protein;Nitric Oxide;novel;Operative Surgical Procedures;overexpression;Pathologic;Patients;Peptide Hydrolases;Perfusion;Peripheral arterial disease;Phosphorylation;Play;preservation;prevent;Prevention;Production;Productivity;Proprotein Convertase 1;Protein Secretion;Proteins;receptor;Reperfusion Injury;Reperfusion Therapy;Research;Role;Signal Pathway;Signal Transduction;Skeletal Muscle;small molecule;Testing;therapeutic target;Tissues;Tourniquets;trans-Golgi Network;Trauma;Vascular Diseases;Vascular Endothelial Cell;vascular inflammation;vascular injury;Vascular System;Wild Type Mouse;Work

PROJECT_TITLE: The role of proBDNF-p75NTR signaling in hind limb ischemia.


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Hematopoietic Stem Cells (HSCs) sustain lifelong hematopoiesis and are clinically valuable in hematopoietic replacement therapies to treat cancers and a variety of hematological diseases. HSCs form embryonically and concurrently with HSC-independent Progenitor Cells (HPCs) that display a more limited capacity to generate blood cell types. Our study will identify molecular mechanisms underlying their distinct differentiation that can be used to improve HSC-based therapies.

PI_NAMEs: NIZHNIK, ANASTASIA  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Address;Adult;Affect;Agreement;Biological Assay;Blood;Blood Cells;Candidate Disease Gene;cell behavior;cell type;Cells;Clinical;CRISPR/Cas technology;Development;Dissection;Embryo;Embryonic Development;Endothelial Cells;Endothelium;Environment;Erythroid;Excision;Experimental Genetics;Gene Mutation;Generations;Genes;Genetic;genetic approach;Genetic Screening;Genomic approach;Goals;granulocyte;Growth;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic differentiation;hematopoietic stem cell differentiation;hematopoietic stem cell formation;Hematopoietic stem cells;Hematopoietic System;hemogenic endothelium;Impairment;improved;In Vitro;in vivo;Inherited;Kinetics;Knowledge;Label;loss of function;Lymphoid;Lymphoid Cell;Malignant Neoplasms;Measures;Methods;Molecular;molecular marker;Mus;Mutagenesis;mutant;Myelogenous;Myeloid Progenitor Cells;Natural Killer Cells;novel;Organism;Output;patient derived induced pluripotent stem cells;Patients;Pluripotent Stem Cells;Population;Process;Property;regenerative;Regenerative capacity;regenerative cell;Replacement Therapy;reverse genetics;RUNX1 gene;self-renewal;single-cell RNA sequencing;Source;spatiotemporal;stem cell differentiation;stem cell fate;stem cell therapy;stem cells;System;T-Lymphocyte;Therapeutic;Tissues;tool;transcription factor;Transplantation;Umbilical Cord Blood;vertebrate embryos;Zebrafish;zebrafish development

PROJECT_TITLE: Dissection of Hematopoietic Stem and Progenitor Cell Differentiation during Embryogenesis


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: NEW YORK

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative Aged-related macular degeneration (AMD) has unclear etiology and no effective treatment. This proposal integrates the interdisciplinary approaches to investigate the contribution of lipid homeostasis to the AMD pathophysiology. The outcomes of these studies have the potential for identifying novel targets to arrest or slow down the AMD disease progression.

PI_NAMEs: SUNG, CHING-HWA  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 3-Dimensional;Address;Age related macular degeneration;Animal Model;Apolipoprotein E;Basic Science;Blindness;Bruch's basal membrane structure;Cellular biology;CLIC4 gene;Compensation;Complex;Comprehension;Coupling;Deposition;Disease;Disease Progression;Docosahexaenoic Acids;Drusen;effective therapy;Elderly;Electron Microscopy;Endosomes;Environmental Risk Factor;Etiology;Exhibits;Fatty Acids;Functional disorder;Genetic;Genetic Risk;geographic atrophy;Goals;Histopathology;Homeostasis;Human;Impairment;In Vitro;in vivo;interdisciplinary approach;Investigation;Knock-out;Knockout Mice;Knowledge;Learning;lipid metabolism;lipid transfer protein;lipidomics;Lipids;Lipoproteins;liquid chromatography mass spectrometry;mass spectrometric imaging;Mediating;Membrane Microdomains;Metabolism;Modeling;mouse model;Mus;new therapeutic target;Nonexudative age-related macular degeneration;novel;Outcome;Outcome Study;Oxidation-Reduction;Pathologic;peroxidation;Peroxides;Phenotype;Phospholipids;Photoreceptors;Play;Polyunsaturated Fatty Acids;Population;Primary Lesion;Proteins;Regulation;Research;Role;Signal Pathway;Site;Sphingolipids;Structure of retinal pigment epithelium;Techniques;Technology;Testing;timeline;trafficking;transcriptome;Triglycerides;Vision;Visual impairment

PROJECT_TITLE: Modeling and mechanistic investigation of a novel dry AMD mouse model with CLIC4 deleted in RPE

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: We are in the midst of a medical revolution at the center of which is genetics and genomics, this period in medical history will likely be known as the “Genomics Era” and underscores the need for intensive and high quality human genetic research training of clinicians (M.D. and M.D., Ph.D.) trained in Pediatrics, Medicine, Psychiatry, Pathology and other specialties. This research training program seeks to provide this training primarily to a diverse group of clinicians in all arenas relevant to human genetics and genomics. This training program will train future medical genetics leaders who are willing and able to apply modern research methods to elucidating the pathogenesis and pathophysiology of medical genetic conditions, as well as understanding how genetics and genomics will contribute to health maintenance through preventative care, so that new and more effective therapeutic interventions can be identified.

PI_NAMEs: GANETZKY, REBECCA  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TITLE: Medical Genetics Research Training Grant


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: This Summer Medical student Aging and Alzheimer disease Research Training (SMAART) program is anticipated to fill the gaps that exist in the availability of physician-scientists to address evolving global health challenges through research, discovery and awareness. This training program will leverage the outstanding mentoring expertise at UCI in aging, Alzheimer’s disease (AD) and related dementias (ADRD), highlighting exposures to clinical, biomarker, anatomical and molecular research. Moreover, the translational emphasis of the research preceptors will enable trainees to be exposed to essential discoveries that contribute to changes in clinical practice.

PI_NAMEs: GRILL, JOSHUA ;HEAD, ELIZABETH  (contact);MONUKI, EDWIN S

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Basic Science;Biological Markers;Biometry;career;career development;Caring;clinical care;Clinical Sciences;Competence;Educational Curriculum;Epidemiology;Ethics;experience;flexibility;Fostering;Generations;Genetic;hands on research;innovation;Journals;Knowledge;Leadership;Liquid substance;medical schools;Medical Students;Mentors;Molecular and Cellular Biology;multidisciplinary;neuroimaging;Neuropsychology;Neurosciences;Patients;Physicians;programs;Public Health;Publishing;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Training;Scientist;skills;Students;Training;Training Programs;translational physician;Translational Research


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Services;Neurosciences;Nutrition;Obesity;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative  A large body of research has demonstrated that intensive lifestyle interventions and metformin are effective treatments to prevent or delay diabetes among high-risk adults, yet neither treatment is routinely used in practice. The Behavioral Nudges for Diabetes Prevention (BEGIN) Trial will test two low-touch interventions designed to motivate adoption of these treatments to prevent diabetes. Given that 38% of U.S. adults have prediabetes, the proposed study has potential for large public health impact by testing pragmatic, scalable, and sustainable approaches based in primary care to promote evidence-based treatment for this common condition.

PI_NAMEs: O'BRIEN, MATTHEW JAMES (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Address;Adherence;Adoption;Adult;automated intervention;Awareness;behavior change;Behavioral;behavioral economics;Body Weight Changes;Body Weight decreased;Caring;Clinic;Clinical;Clinical Research;Collaborations;common treatment;Communication;Conflict (Psychology);cost;Data;data infrastructure;data resource;Decision Aid;design;Diabetes Mellitus;Diabetes prevention;diabetic patient;disorder risk;effective therapy;Effectiveness;effectiveness testing;Environment;ethnic minority;Evaluation;evidence base;Evidence based treatment;experience;Family health status;Glycosylated hemoglobin A;Health;Health behavior;Health Educators;High Prevalence;high risk;improved;Individual;information display;innovation;Intervention;Knowledge;Letters;lifestyle intervention;Maintenance;Metformin;Methods;Minority;Motivation;Neighborhood Health Center;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Office Visits;Outcome;Overweight;Participant;patient oriented;patient population;Patients;Persons;Pilot Projects;Poverty;pragmatic trial;Prediabetes syndrome;prevent;Prevention Research;Prevention trial;Primary Care;primary care clinic;primary care patient;Primary Care Physician;primary outcome;Public Health;public health priorities;racial minority;randomized trial;recruit;Research;Research Design;Risk;secondary outcome;Shoulder;study population;success;System;Testing;Text Messaging;therapy design;tool;Touch sensation;treatment as usual;treatment choice;uptake;Weight;Work

PROJECT_TITLE: Behavioral Nudges for Diabetes Prevention (BEGIN) Trial in Primary Care


NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE. The proposed research is relevant to public health because it will elucidate the fundamental biological processes by which the immune system is dysregulated in response to chronic inflammation. This essential knowledge is required to understand the role of mucosal immunity in intestinal homeostasis and development of diseases such as inflammatory bowel disease. This work will therefore directly support the overall NIH mission of developing fundamental knowledge that will help reduce the burden of human disease and promote the NIDDK goal of improving digestive health.

PI_NAMEs: EDELBLUM, KAREN LEIGH (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Affect;American;Anti-Inflammatory Agents;Apoptotic;Behavior;Biological Process;Biology;Cells;Chronic;Crohn's disease;Data;defined contribution;Development;diphtheria toxin receptor;Disease;Enterocytes;Epithelial Cells;Epithelium;Event;Frequencies;Future;Gene Targeting;Goals;Granzyme;Health;Heterogeneity;Histologic;Homeostasis;Host Defense;Human;human disease;Ileal Diseases;Ileitis;Imaging Techniques;Immune system;Immunologic Surveillance;immunoregulation;improved;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;intestinal barrier;Intestinal Content;intestinal epithelium;intestinal homeostasis;Intestinal permeability;intraepithelial;intravital microscopy;Knowledge;Lymphocyte;Lymphocyte Subset;Maintenance;microbial;microorganism;migration;Mission;Modeling;Molecular;Motility;mouse model;Mucosal Immune System;Mucosal Immunity;Mucous Membrane;murine colitis;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;novel;Onset of illness;Pathogenesis;Patients;Peripheral;Population;prevent;Process;Public Health;Publishing;receptor function;recruit;Recurrent disease;Regulation;Regulatory T-Lymphocyte;Relapse;relapse prediction;Reporter;Reporting;Research;response;response to injury;Role;Sentinel;T cell infiltration;T-Cell Receptor;T-Lymphocyte;therapy design;TNF gene;transcriptomics;United States National Institutes of Health;Villous;Work

PROJECT_TITLE: gd IELs in chronic ileitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-H(03)]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative Desmosomes are specialized complexes, necessary for normal cell interactions in the heart. Desmoplakin links the desmosomal components to the cytoskeleton through intermediate filaments, and genetic mutations that disrupt desmoplakin lead to an inflammatory form of cardiomyopathy with irregular heart rhythms. This study will assess the role of innate immune activation using human induced pluripotent stem cells (hiPSCs) containing truncating variants in DSP to demonstrate the potential for immune modulation in preventing disease progression of DSP-associated arrhythmogenic cardiomyopathy.

PI_NAMEs: SELGRADE, DANIEL  (contact)

PROJECT_TERMS: 3-Dimensional;Adrenergic Agents;Affect;Arrhythmia;arrhythmogenic cardiomyopathy;Biological Assay;Calcium;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiomyopathies;Cell Communication;Cell Death;Cell Line;Cells;Clinical;clinical imaging;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complex;cytokine;Cytoskeleton;Data;Defect;desmoplakin;Desmosomes;Development;differential expression;Dilated Cardiomyopathy;Disease;Disease Progression;disorder prevention;DNA Sequence Alteration;DSPP gene;effectiveness evaluation;Epigenetic Process;Exposure to;Fibroblasts;Functional disorder;Future;Gap Junctions;Gene Expression;Genes;Genetic Transcription;Heart;Heart Diseases;Heart failure;heart imaging;heart rhythm;Heterozygote;human induced pluripotent stem cells;Immune;immune activation;Immunologics;immunomodulatory therapies;immunoregulation;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inflammasome;Inflammation;Inflammatory;inflammatory modulation;innate immune pathways;insight;Intercalated disc;Intercellular Junctions;Intermediate Filaments;Investigation;Lead;Left;Left Ventricular Function;Left ventricular structure;Link;link protein;Macromolecular Complexes;Magnetic Resonance;Measures;Mediating;Mediator;Mitosis;Modeling;mRNA Expression;Mutation;Myocarditis;Nature;Neonatal;Normal Cell;pathogen;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Phosphotransferases;Positron-Emission Tomography;prevent;Production;prognostic indicator;programs;protein expression;Proteins;Rattus;recruit;response;Role;Severity of illness;Signal Transduction;Skin;Small Interfering RNA;small molecule;stem cell model;Testing;Therapeutic;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;Variant;Ventricular;Ventricular Arrhythmia;Visualization;Work

PROJECT_TITLE: Dissecting the Role of Desmoplakin in Inflammation in Cardiomyopathy


NIH_SPENDING_CATS: Brain Disorders;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Primary Health Care;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Addiction, HIV and HCV commonly co-occur which requires integration of care, and few researchers have been prepared to pursue this research agenda. We will continue a successful interdisciplinary pre-doctoral training program that encompasses the coursework phase of the trainee's doctoral degree program, requiring health services research theory and methods, enhanced by courses in addictions and/or infectious disease and implementation science, and including research rotations bringing trainees into clinical settings to apply mixed methods research. We are preparing trainees to disseminate research findings and translate them into practice and policy in these important areas.

PI_NAMEs: ADAMS, RACHEL SAYKO;STEIN, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TITLE: Integrated Care for Addiction, HIV and HCV Research and Education (ICAHRE)


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: The Graduate Program in Genetics & Genomics trains a new generation of students in research topics that are directly related to human genetics, health, physiology, and disease. Training the next generation of geneticists in these subjects is essential for the continued development of health care in the US and throughout the world, especially in the era of personalized genomic medicine.

PI_NAMEs: SHAULSKY, GAD  (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Genetic;Genomics;Training Programs

PROJECT_TITLE: Genetics & Genomics Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Retinal vascularization in humans occurs in gestation, reaching completion at 36 weeks, and it is a crucial developmental event involving precisely timed and localized events. Defects in any step of the process or halting it before its full completion will lead to mispatterned or incomplete vascular coverage of the retina, which are hallmarks observed in retinopathologies such as retinopathy of prematurity (ROP). Completion of this work will elucidate unknown mechanisms of glial regulation of retinal angiogenesis, while also pinpointing important molecular cues that may be involved in angiogenesis during pathogenic conditions.

PI_NAMEs: VALDEZ-LOPEZ, JUAN  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adopted;adrenomedullin;adrenomedullin receptor;Alleles;angiogenesis;Angiogenic Factor;Astrocytes;Autocrine Communication;Automobile Driving;Axon;Binding;Bioinformatics;Biological Assay;Blindness;Blood capillaries;Blood Vessels;calcitonin receptor-like receptor;cell growth;Cell surface;cell type;Cells;Child;Childhood;Coculture Techniques;Cues;Data;Databases;Defect;Development;developmental disease;Disease;Endothelial Cells;Event;Future;ganglion cell;Genes;Human;Hypoxia;In Vitro;in vivo;insight;Knowledge;Mediating;Microglia;Molecular;Molecular Target;Mus;Nerve Fibers;Nervous System;nervous system development;Neurophysiology - biologic function;new therapeutic target;novel;Optic Nerve;Outcome;Pathogenicity;Pathology;Pathway interactions;Pattern;Peptides;Porifera;Positioning Attribute;Pregnancy;prevent;Process;Production;Property;Radial;RAMP2;receptor;receptor-activity-modifying protein;recruit;Regulation;Retina;retinal angiogenesis;Retinal Ganglion Cells;retinal nerve fiber layer;Retinopathy of Prematurity;Risk;selective expression;Signal Transduction;single-cell RNA sequencing;Source;Testing;Vascular Endothelial Growth Factors;Vascularization;Work

PROJECT_TITLE: Astrocyte-specific molecular cues guiding retinal angiogenesis


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: Portage

ORG_NAME: GLOBAL FOOD PROTECTION INSTITUTE D/B/A INTERNATIONAL FOOD PROTECTION TRAINING INSTITUTE

ORG_STATE: MI

PHR: RFA-FD-20-024 – Project Narrative The International Food Protection Training Institute (IFPTI) will continue to lead the development of the Integrated Food Safety System National Curriculum Standard (NCS) in close collaboration with the FDA Office of Training Education and Development (OTED) and other Cooperative Agreement recipients such as the Association of Food and Drug Officials, the National Environmental Health Association, and the Association of Public Health Laboratories. Highlights of the proposed project include the continued facilitation of subject matter expert focus groups to build out competency-based curriculum frameworks for Regulators of human and animal food; the development of course blueprints and design documents according to OTED specifications; the development of a competency-based Leadership Program; the delivery of Instructor Skills Training and the Fellowship in Food Protection program; and the continued development of standardized processes related to course design and delivery and instructor management. Continuing the development of the NCS is crucial for creating a competent regulatory food protection workforce doing comparable work across all agency jurisdictions (Federal, State, local, tribal, and territorial), thereby achieving the overarching public health mission of a safe food supply. .

PI_NAMEs: KAML, CRAIG  (contact)

PROGRAM_OFFICER_NAME: COPELAND, KIA

PROJECT_TITLE: Continuing the Development of the Integrated Food Safety System (IFSS) National Curriculum Standard (NCS) Curriculum Frameworks


ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Narrative The Stony Brook School of Medicine is committed to the training of future physician-scientists to address a pressing need for individuals who can undertake scientific discovery with direct relevance to human health. Trainees undertake a rigorous academic program that culminates in the awarding of an MD and a PhD and many go on to become leaders in biomedical research.

PI_NAMEs: FROHMAN, MICHAEL A. (contact)

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program


PHR: NARRATIVE Genetics and genomics are foundational disciplines central to all biomedical research and its applications in clinical practice and precision medicine. The mission of the proposed predoctoral training program is to educate the next generation of scientists to advance biomedical research through the rigorous and creative application of genetic principles, genomic technologies, and rapidly evolving computational tools. Our objective is to train students to generate new knowledge and develop creative and impactful solutions to pressing problems affecting human health.

PI_NAMEs: ALBERT, FRANK WOLFGANG;GREENSTEIN, DAVID IRWIN (contact);SELMECKI, ANNA M.

PROJECT_TITLE: An Interdisciplinary Training Program to Transform Graduate Education In Genetics and Genomics

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The University of Alabama Heersink School of Medicine’s (UAB HSOM’s) Department of Neurobiology leads an outstanding training program designed to train a diverse cadre of Ph.D. scientists to address mechanisms of Cognition and to identify future therapeutic approaches for Cognitive Disorders. This training program is tailored to provide clinical exposure along with cutting-edge training in neuroscience, quantitative methodologies, statistics, responsible conduct of research, critical thinking and error analysis, career pathways, and more. As the burden of cognitive disorders grows in an aging population, preparing the next generation of neuroscientists studying Cognition and Cognitive Disorders is more important now than ever.

PI_NAMEs: LUBIN, FARAH DOMINIQUE (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Cognition Disorders;Neurobiology;Research Training;Training Programs

PROJECT_TITLE: UAB Research Training Program in Neurobiology of Cognition and Cognitive Disorders


NIH_SPENDING_CATS: Cardiovascular

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE This is the first renewal for T32 postdoctoral training support of MDs, PharmDs, and PhDs which leverages institutional strengths and scientific excellence in atherosclerosis, thrombosis, and vascular biology, cardiac biology and heart failure, precision cardiovascular medicine, and hypertension research. Our commitment for excellence in research training is demonstrated by 36% of appointees coming from underrepresented groups and 100% of graduates with further federal funding and has foundations in the core values of diversity, mentorship, and improved health outcomes by training the next generation of cardiovascular scientists and physicians, including those from underrepresented groups, through broad-based, personalized, supportive, and rigorous training opportunities. At a time when the burden of cardiovascular disease continues to rise and the pipeline of investigators, especially clinicians dwindles, our training program is designed to invigorate the recruitment and development of those who will make the next series of advances in research to improve cardiovascular health.

PI_NAMEs: BENJAMIN, IVOR JAMES (contact);SORCI-THOMAS, MARY G

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Cardiovascular system;Science;Training

PROJECT_TITLE: Training in Signature Transdisciplinary Cardiovascular Sciences


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE It is estimated that nearly 10% of the US population has diabetes, and the percentage with obesity and pre- diabetes is alarmingly higher. A goal of the Indiana Diabetes Research Center is to leverage resources, a highly talented pool of basic and translational researchers, and a rich environment of learning and collaboration to tackle the causes, diagnoses, and treatment of diabetes and related metabolic disorders and their complications.

PI_NAMEs: EVANS-MOLINA, CARMELLA  (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Advocate;Animal Experimentation;Animals;Award;Awareness;base;Basic Science;Bioinformatics;Biological Sciences;Biomedical Engineering;catalyst;Child;Clinical Research;Collaborations;collaborative environment;Communities;Complications of Diabetes Mellitus;Development;Diabetes Mellitus;Diagnosis;Disease;Ecosystem;educational atmosphere;Endocrine System Diseases;Ensure;Evolution;Extramural Activities;Family suidae;Financial Support;Fostering;Foundations;Funding;Future;Genomics;Goals;Grant;Growth;Human;human subject;human tissue;Indiana;Individual;Influentials;Informatics;Infrastructure;innovation;Institution;islet;Knowledge;Learning;medical schools;member;Mentors;Mentorship;metabolic abnormality assessment;Metabolic Diseases;Metabolism;Methodological Studies;Microscopy;Mission;model organism;Molecular;National Institute of Diabetes and Digestive and Kidney Diseases;new growth;next generation;novel;nutrition;Nutritional Study;Obesity;Physiology;Population;Postdoctoral Fellow;Prediabetes syndrome;programs;Proteomics;Research;Research Infrastructure;Research Institute;Research Methodology;Research Personnel;Research Project Grants;Resources;Scientist;Series;Structure;Students;symposium;System;Talents;Training;Training Support;Translational Research;translational scientist;Translations;United States National Institutes of Health;Universities;Visit

PROJECT_TITLE: Indiana Diabetes Research Center


NIH_SPENDING_CATS: Diabetes

PROJECT_TERMS: Atmosphere;base;Basic Science;Businesses;career;Clinical;Collaborations;Communication;Communities;Critical Thinking;Data;Dedications;Diabetes Mellitus;Discipline;Doctor of Philosophy;Education;Ensure;Environment;environmental enrichment for laboratory animals;Equipment;Event;Evolution;Faculty;Feedback;Fostering;Funding;Growth;Health;Human Resources;Indiana;Leadership;Maintenance;Medical Students;Metabolic Diseases;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of General Medical Sciences;operation;Policies;Postdoctoral Fellow;pre-doctoral;programs;Reagent;Research;Research Personnel;Resource Allocation;Resources;Sampling;Scientist;Series;Services;skills;Specialist;Structure;Students;success;symposium;Training;Training and Education;Training Programs;Training Support;Translational Research;Visit;web site

PROJECT_TITLE: Administrative Core


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: The goal of this MSTP training program is to train students to move fluidly between the realms of rigorous experimental or computational biology and compassionate, evidence- based care of patients. We will develop a diverse pool of well-trained physician scientists through high quality research training, clinical training, and mentored research and clinical experiences. Our trainees will be equipped with clinical, research, and professional skills to make significant contributions to the advancement of biomedical science and health care.

PI_NAMEs: SULMAN, ERIK  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: Medical Scientist Research Service Award


NIH_SPENDING_CATS: Diabetes;Nutrition

PROJECT_TERMS: Back;base;Body Composition;Center for Translational Science Activities;Collaborations;Consultations;Data Analyses;Development;Diabetes Mellitus;Eating;Energy Metabolism;experience;Experimental Designs;experimental study;Family suidae;Fostering;glucose tolerance;high standard;Human;Indiana;Informatics;Institution;Insulin Resistance;investigator training;islet;Islets of Langerhans Transplantation;Leadership;medical schools;member;Metabolic;Metabolic Diseases;metabolic phenotype;Microscopy;Mission;Pancreas;Physiology;Reproducibility;Research;Research Personnel;Rodent;Services;System;Techniques;Tissues;Training;Training Support;Universities;Work;Zebrafish

PROJECT_TITLE: Islet & Physiology Core


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

PHR: Primary open-angle glaucoma (POAG) is an intraocular pressure-related chronic optic nerve disease that produces characteristic visual loss patterns. In this proposal we will study the clinical impact of cumulative common genetic variants in relation to this disease. Overall this work will help translate gene discovery efforts into precision medicine approaches for the diagnosis, prevention and treatment of POAG.

PI_NAMEs: PASQUALE, LOUIS ROBERT (contact);WIGGS, JANEY L

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Affect;Age;aged;Aging;Area;Attention;biobank;Blindness;Candidate Disease Gene;Cardiovascular Diseases;Case/Control Studies;Characteristics;Chronic;Clinical;clinical phenotype;clinically relevant;Collaborations;Complex;Consensus;Consent;Data;Databases;Derivation procedure;Detection;Diabetes Mellitus;Diagnosis;Diagnostic tests;dietary nitrate;Discipline;Disease;Disease Outcome;Disease Progression;disorder prevention;disorder risk;Early Diagnosis;electronic health information;Electronic Health Record;endophenotype;Environmental Exposure;Environmental Risk Factor;Estrogens;ethnic diversity;Ethnic Origin;Evaluation;feature detection;field study;Follow-Up Studies;Frequencies;Fundus photography;gene discovery;Genetic;Genetic Risk;genetic variant;genome wide association study;genomic locus;Genotype;Glaucoma;Goals;Health Professional;Health Status;Healthcare;Heritability;Hospitals;Human Genetics;improved;Individual;insight;Intake;International;Knowledge;Linkage Disequilibrium;Longitudinal Studies;Measures;Medical;medical schools;multi-ethnic;National Eye Institute;Nerve Fibers;novel;Nurses' Health Study;optic nerve disorder;Oral health;Papillary;Patient-Focused Outcomes;Patients;Pattern;personalized approach;Persons;Phenotype;Physiologic Intraocular Pressure;polygenic risk score;Population;population based;Populations at Risk;precision medicine;Prevalence;prevent;Prevention;Prevention strategy;Primary Open Angle Glaucoma;Probability;programs;Progressive Disease;Receiver Operating Characteristics;Recording of previous events;Research;research clinical testing;Risk;risk prediction;risk variant;Role;Sample Size;Sampling;screening;Screening procedure;sex;Site;Source;study population;Sum;Testing;tomography;tool;Translating;United States National Institutes of Health;Variant;Vegetables;Visual Fields;Weight;Women's Health;Work

PROJECT_TITLE: Understanding the clinical impact of cumulative genetic risk to glaucoma


NIH_SPENDING_CATS: Clinical Research;Diabetes

PI_NAMEs: HANNON, TAMARA S (contact)

PROJECT_TERMS: Animals;Biological Models;chemical standard;Clinical;Clinical Investigator;Collaborations;Collection;cost;Cost Measures;Cultured Cells;cytokine;design;Diabetes Mellitus;Fostering;Hormones;Human;Human Biology;human disease;human subject;Human Subject Research;human tissue;in vivo;Indiana;Institution;interest;Laboratories;Measurement;Measures;medical schools;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Methodology;Mission;Molecular;novel;Performance;Physiological;Physiology;pre-clinical;programs;Research;Research Personnel;Sampling;Students;Study Subject;Tissue Sample;Training;Training Support;translation to humans;translational study;Translations;Universities;Work

PROJECT_TITLE: Translation Core


PI_NAMEs: LINNEMANN, AMELIA K (contact)

PROJECT_TERMS: 20 year old;Anesthesia procedures;Animals;Basic Science;Biological;Biological Assay;biological systems;Biosensor;Brain;Budgets;capsule;Cell Physiology;Cells;Cellular biology;Charge;Collection;Contract Services;cost;Data Storage and Retrieval;design;Development;Diabetes Mellitus;digital;digital imaging;discount;experience;Fluorescence;fluorescence lifetime imaging;Fostering;Functional disorder;Goals;Grant;Hour;Human;Image Analysis;imaging approach;imaging modality;In Vitro;Indiana;Individual;Infrastructure;interest;intravital microscopy;islet;Islets of Langerhans Transplantation;Kidney;Knowledge;Laboratories;light microscopy;Liver;Manufacturer;medical schools;Metabolic Diseases;Methods;Microscope;Microscopy;Mission;Modeling;Monitor;multi-photon;multiphoton microscopy;Mus;Muscle;Neurons;novel;Operative Surgical Procedures;Pancreas;Performance;Physiology;protein function;Proteins;Reagent;Research;Research Personnel;research study;Savings;Scanning;Schedule;Scientist;Services;System;technique development;Techniques;Three-Dimensional Image;Time;tissue resource;Training;Training Support;Translational Research;two-dimensional;Validation;vector;Viral Vector;Work

PROJECT_TITLE: Microscopy Core


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Bioengineering;Muscular Dystrophy;Myasthenia Gravis;Neurosciences;Rare Diseases;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: Loss of muscle function in chronic neuromuscular disease (NMD) is debilitating to quality of life and is associated with high healthcare burden. A major barrier in the development of effective therapies for NMDs is our limited of understanding of the various types of cells involved in normal muscle repair and what goes awry in disease. Here, I develop novel technologies to simultaneously visualize and study the interaction of more than 25 cell types in skeletal muscle, which will allow us to uncover critical interactions that determine efficient muscle regeneration as well as pinpoint disruptions in chronic NMD.

PI_NAMEs: WANG, YU XIN  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Acute;age related;Algorithms;Antibodies;Autoimmune;Autoimmune Responses;Autoimmunity;Behavior;Bioinformatics;Biological Process;Biology;Breathing;Cell Communication;cell type;Cells;Chronic;Collaborations;Computational algorithm;connectome;Cytometry;Data;Denervation;Development;Disease;effective therapy;empowerment;Experimental Autoimmune Myasthenia Gravis;experimental study;Goals;healthcare burden;Imaging technology;Immune;in vitro regeneration;in vivo;Injury;insight;intercellular communication;Ligands;Macrophage;Maps;mdx mouse;Mentors;Metabolism;Methods;Modeling;Molecular;Motor Neurons;mouse model;Movement;multi-scale imaging data;multiplexed imaging;Muscle;Muscle Cells;Muscle Fibers;Muscle function;muscle progenitor cell;muscle regeneration;muscle repair;Muscular Atrophy;Myasthenia Gravis;myogenesis;Myopathy;Natural regeneration;Nerve;Nerve Crush;nerve injury;Neuroglia;neuromuscular;Neuromuscular Diseases;Neuromuscular Junction;new technology;novel;Persons;Phase;Population;Posture;Process;progenitor;programs;PTPRC gene;Quality of life;reinnervation;Research;Resolution;response;restoration;Role;sarcopenia;sciatic nerve;Signal Transduction;Signaling Molecule;Skeletal Muscle;Sprains and Strains;Standardization;stem cell function;stem cells;strain injury;success;Technology;therapy development;tissue regeneration;tissue repair;Tissues;Training;transcriptomics;unsupervised learning;Visualization

PROJECT_TITLE: Spatial Regulators of Skeletal Muscle Regeneration and Disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


PI_NAMEs: MOSLEY, AMBER L. (contact)

PROJECT_TERMS: Animal Model;Atherogenic Diet;bariatric surgery;Biotechnology;Body Composition;Breeding;Calories;Catheters;Chemicals;Cholesterol;Clinical Medicine;Collaborations;comorbidity;comparative;Complex;Control Groups;Corvus;cost effectiveness;cost efficient;Data;data repository;Diabetes Mellitus;diabetic;Diet;Dyslipidemias;Endocrine;Family suidae;Fasting;Funding;Glucose;Glucose Clamp;Health;High Density Lipoproteins;Human;human disease;human model;imaging study;impaired glucose tolerance;Implant;improved;in vivo;indexing;Indiana;Informatics;Insulin Resistance;Intervention;Intravenous;islet;Kidney Calculi;Licensing;Lipids;Lithotripsy;Liver;Low-Density Lipoproteins;medical schools;Medicine;Metabolic;metabolic abnormality assessment;Metabolic syndrome;Metabolism;Methods;Microscopy;Miniature Swine;Modeling;Molecular;Monitor;mouse model;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;operation;Oral;Pathogenesis;Phenotype;Physiology;Positron-Emission Tomography;Production;Research;Research Personnel;Resource Sharing;Resources;Rodent;Services;Severities;Skeletal Muscle;Stents;System;Testing;Therapeutic;Thinness;Tissue Banks;Tissues;Transgenic Mice;translation to humans;Translational Research;Translations;Triglycerides;Ultrasonography;Universities;X-Ray Computed Tomography

PROJECT_TITLE: Data and Analytics Core


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative The Interdisciplinary Training Program in Psychiatry and Neuroscience provides postdoctoral research training in areas relevant to the neurobiological bases of mental disorders. The goal of the program is to prepare the next generation of psychiatric researchers for independent research careers to investigate the biology of mental disorders.

PI_NAMEs: MARGOLIS, RUSSELL L (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Neurosciences;Psychiatry;Training

PROJECT_TITLE: Interdisciplinary Training in Psychiatry and Neuroscience


PI_NAMEs: ELMENDORF, JEFFREY S (contact)

PROJECT_TERMS: Address;Area;Award;Basic Science;Biological Sciences;Collaborations;Communities;Complications of Diabetes Mellitus;Core Facility;Critiques;Development;Diabetes Mellitus;Discipline;Extramural Activities;Fostering;Funding;Funding Agency;Future;Goals;Grant;Indiana;innovation;Institution;interest;Investigation;Investments;Knowledge;medical schools;member;Mentors;Mentorship;Metabolic Diseases;Mission;novel therapeutic intervention;Peer Review Grants;Persons;Probability;Problem Solving;Productivity;programs;Research;Research Institute;Research Personnel;Research Support;Research Technics;Source;success;technology/technique;Training Support;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Pilot & Feasibility Progam