NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: MCMILLAN, COREY T (contact)

PROJECT_TERMS: 3-Dimensional;Aging;Anatomy;arterial spin labeling;Autopsy;behavioral variant frontotemporal dementia;Bilateral;Bioinformatics;Biological;Biological Testing;Brain;Cells;Cerebrum;Clinical;clinical phenotype;Collaborations;Collection;comparative;Complex;connectome;Data;Dedications;demented;Detection;Diagnostic;Diffusion Magnetic Resonance Imaging;diffusion weighted;Discrimination;Disease;disease heterogeneity;frontotemporal degeneration;Frontotemporal Lobar Degenerations;Functional Magnetic Resonance Imaging;Genetic;Genotype;Goals;Graph;gray matter;Heterogeneity;Human;Image;image processing;image registration;Imaging Techniques;improved;in vivo;in vivo imaging;Individual;Infrastructure;insight;interest;Left;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Methods;Morphologic artifacts;Motion;MRI Scans;multimodal neuroimaging;Nerve Degeneration;network dysfunction;neuroimaging;neuron loss;neuropathology;Neurosciences;novel;open source;Parietal Lobe;Pathologic;Pathology;Pathway Analysis;Patients;Pattern;Perfusion;Phenotype;Primary Progressive Aphasia;prisma;Procedures;programs;Property;prospective;protein TDP-43;Protocols documentation;recruit;Regional Anatomy;Reproducibility;Research;Resolution;Resources;Rest;serial imaging;Series;Source;Structure;support network;Syndrome;tau Proteins;Tauopathies;Thick;Time;tool;Translating;ultra high resolution;Water;white matter;White Matter Disease

PROJECT_TITLE: Core C: Neuroimaging Core


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Childhood Injury;Clinical Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: PROVIDENCE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Bystander-approaches to sexual violence prevention are increasingly common on college campuses, yet there is a need for research to understand the real-world situational factors that promote bystander behavior. The current study will use weekend morning reports to answer key questions about the within-person effects of alcohol intoxication and situational context on bystander behavior in social drinking contexts. Results from morning reports and focus groups will be valuable for the refinement of situational models of bystander behavior and the improvement of empirically-informed bystander-focused sexual violence prevention.

PI_NAMEs: HAIKALIS, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: addiction;Alcohol consumption;alcohol effect;alcohol prevention;alcohol research;Alcoholic Intoxication;Alcohols;Area;assault;Award;Behavior;Bystander Effect;career;career development;Characteristics;Clinical;Clinical Sciences;college;combat;contextual factors;Data;Data Collection;Data Reporting;Dedications;Development;Development Plans;Diffusion;Distal;drinking;Educational workshop;Elements;empowerment;Environment;Evaluation;Event;experience;Focus Groups;Foundations;frontier;Future;Goals;Grant;improved;Individual;infancy;interest;Intervention;Intoxication;Investigation;K-Series Research Career Programs;Knowledge;Laboratories;Leadership;Link;Location;Manuscripts;meetings;member;Mentors;Mentorship;Meta-Analysis;Methodology;Methods;Modeling;multilevel analysis;National Institute on Alcohol Abuse and Alcoholism;novel strategies;Outcome;Participant;Persons;Prevention;Prevention program;Process;programs;Proliferating;protective factors;Public Health;Public Health Schools;Qualitative Methods;Reaction;Recommendation;Recording of previous events;Reporting;Research;Research Activity;Research Design;Research Personnel;Research Priority;Research Project Grants;Research Support;response;Risk;Risk Factors;Scientist;sexual assault;sexual violence;Sexual violence prevention;skills;social;Specificity;Statistical Data Interpretation;Strategic Planning;Students;success;Sum;Survivors;Talents;Testing;theories;Training;Training Activity;Training Programs;translational research program;Universities;university student;Variant;violence prevention;Work;Writing

PROJECT_TITLE: Event-Level Analysis of Alcohol Use and Bystander Behavior in Social Drinking Contexts: A Novel Approach to Inform Alcohol-Related Sexual Assault Prevention

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PI_NAMEs: LEE, EDWARD BYUNG-HA (contact)

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Archives;Autopsy;autosome;Behavioral;Bioinformatics;Biological Markers;Biometry;Brain;brain tissue;C9ORF72;Cells;Clinical;Clinical assessments;clinical phenotype;Collaborations;Complex;Data;Data Storage and Retrieval;Databases;Dementia;Diagnosis;Disease;DNA;DNA Library;DNA Sequence Alteration;Doctor of Philosophy;Dominant Genes;Exhibits;frontotemporal degeneration;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;Gene Mutation;Genes;Genetic;genetic analysis;Genetic Heterogeneity;Genetic Transcription;genetic variant;Goals;Heterogeneity;Histopathology;human old age (65+);improved;Individual;Language;Magnetic Resonance Imaging;Mutation;Nerve Degeneration;neural network;Neurodegenerative Disorders;neuroimaging;Neurons;neuropathology;Nucleic Acids;Pathogenicity;Pathologic;Pathology;Patients;Persons;Program Research Project Grants;protein TDP-43;Proteins;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;risk variant;Scientist;Single Nucleotide Polymorphism;Specimen;Subgroup;Syndrome;tau Proteins;Tissue Banks;Tissue Sample;Tissues;Training;treatment group;Variant;Work

PROJECT_TITLE: Neuropathology & Genetics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: XIE, SHARON XIANGWEN (contact)

PROJECT_TERMS: Aging;Bioinformatics;Biological;Biological Markers;Biometry;Cells;Characteristics;Clinical;Collaborations;Complex;Computer software;Computer Systems;Data;Data Analyses;data management;data quality;Databases;Development;frontotemporal degeneration;Frontotemporal Lobar Degenerations;Functional disorder;Generations;Genetic;Goals;Grant;Graph;Heterogeneity;high dimensionality;Image;insight;Knowledge;Life;Manuscripts;medical schools;Methodology;neuroimaging;neuropathology;novel;open source;operation;Pathologic;Pathology;Pattern;Pennsylvania;Play;Preparation;Procedures;Program Research Project Grants;protein TDP-43;Publications;Quality Control;Questionnaire Designs;relational database;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Role;Sample Size;Security;Services;single-cell RNA sequencing;Site;Statistical Methods;statistics;support network;Syndrome;tool;transcriptome;transcriptomics;Universities

PROJECT_TITLE: Biostatistics and Database Core


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Drug addiction is associated with long-lasting changes in brain function that cause relapse vulnerability, even after extended drug abstinence. The proposed experiments will provide insight into the role that a subset of interneurons in the nucleus accumbens, responsible for the release of nitric oxide, play in mediating the synaptic plasticity underlying cocaine seeking behavior. The proposed research has the potential to reveal novel neurobiological mechanisms of cocaine addiction, and will contribute to the development of novel therapeutic options aimed at reversing cocaine-induced alterations.

PI_NAMEs: SCOFIELD, MICHAEL DAVID (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: addiction;Anesthesia procedures;Animals;Astrocytes;Behavior;Brain;cell type;Chemosensitization;Clinical;Cocaine;cocaine cue;Cocaine Dependence;cocaine seeking;cocaine self-administration;cohort;Corpus striatum structure;cue reactivity;Cues;Data;Dendritic Spines;design;Development;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;Down-Regulation;drug abstinence;Drug Addiction;drug craving;Electrophysiology (science);experimental study;Exposure to;Extinction;Genetic;Glutamate Receptor;Glutamate Transporter;Glutamates;Head;insight;Interneurons;Investigation;knock-down;Label;Link;Measures;Mediating;metabotropic glutamate receptor 5;Microscopic;Morphology;Mus;neurobiological mechanism;Neurobiology;neuron loss;Neurons;Neurotransmitters;Nitrergic Neurons;Nitric Oxide;Nitric Oxide Synthase Type I;novel;novel therapeutics;Nucleus Accumbens;patch clamp;Pharmaceutical Preparations;Pharmacotherapy;Play;prevent;Production;promoter;Rat Transgene;Rattus;receptor;Relapse;relapse prevention;Research;response;Rodent;Rodent Model;Role;Saline;Signal Transduction;Slice;small hairpin RNA;Source;Sucrose;Synapses;Synaptic plasticity;System;Testing;Therapeutic;Therapeutic Intervention;Time;tool;Training;Transgenic Mice;Translating;vector;Ventral Tegmental Area;Viral;Viral Vector;wireless

PROJECT_TITLE: Nitrergic interneurons and cue-induced cocaine seeking

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Tobacco

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PI_NAMEs: HIGGINS, STEPHEN T (contact)

PROJECT_TERMS: Accident and Emergency department;addiction;Advisory Committees;Applications Grants;Area;Behavior;behavior change;Cardiopulmonary;career;Centers of Research Excellence;Cessation of life;Chronic Disease;Clinical Research;Clinical Services;Collaborations;cost effective;Data;Dedications;design;Development;early-career faculty;Evaluation;Feedback;Financial Hardship;Fostering;Foundations;Funding;Grant;Growth;Health;Health Priorities;Healthcare Systems;improved;Individual;innovation;Intervention;Leadership;Medical center;meetings;Mentors;Mentorship;Mission;multidisciplinary;National Institute of General Medical Sciences;Neurobiology;opioid use disorder;Oral;Pattern;Peer Review;Pharmaceutical Preparations;Phase;Pilot Projects;premature;Process;Productivity;programs;Public Health;Publications;Research;Research Personnel;Research Project Grants;Risk;Rural;Science;Series;Tobacco;tobacco control;tobacco regulatory science;United States National Institutes of Health;Universities;Vermont;Work;working group;Writing

PROJECT_TITLE: Pilot Project Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

PROJECT_TERMS: Affect;Aging;Algorithms;Anatomy;Anterior;Area;Autopsy;behavioral variant frontotemporal dementia;Biochemistry;Bioinformatics;Biometry;Biostatistics Core;Brain;Brain region;brain tissue;cell type;Cells;Cellular biology;Cessation of life;cingulate gyrus;Clinical;clinical heterogeneity;clinical phenotype;Complex;Data;Data Set;Dementia;design;Disease;Disease Progression;Experimental Models;frontal lobe;frontotemporal degeneration;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Gene Expression;Genetic;Goals;graph theory;grasp;Heterogeneity;Human;human data;human disease;human RNA sequencing;Immunohistochemistry;improved;Individual;Inferior;Knowledge;Language;Ligands;Methods;Microscopic;Molecular;molecular phenotype;neocortical;Network-based;Neuroanatomy;Neurodegenerative Disorders;Neurologic;Neurons;neuropathology;Nodal;novel;Onset of illness;Pathologic;Pathology;Phenotype;Primary Progressive Aphasia;Progressive Aphasias;protein aggregation;protein TDP-43;receptor;Resources;Series;single-cell RNA sequencing;Stereotyping;Syndrome;System;tau Proteins;Temporal Lobe;Testing;Tissues;transcriptome sequencing;Variant

PROJECT_TITLE: Molecular Network Degeneration in FTLD-Related Pathology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Aphasia;Behavioral and Social Science;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Precision Medicine;Rare Diseases

PROJECT_TERMS: adeno-associated viral vector;Adult;Aging;Alleles;ALS patients;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotides;Autopsy;autosome;Behavioral;behavioral variant frontotemporal dementia;Biological;burden of illness;C9ORF72;Cells;Clinical;Complex;control theory;Disease;disease phenotype;Disease Progression;Disparate;DNA;DNA Methylation;DNA Sequence Alteration;dosage;Epigenetic Process;epigenetic variation;Evaluation;frontotemporal degeneration;frontotemporal lobar dementia amyotrophic lateral sclerosis;Gene Expression;Gene Expression Profile;gene therapy;Genes;Genetic;Genetic Variation;Genotype;Graph;gray matter;Hereditary Disease;Heterogeneity;Hypermethylation;Image;in vivo;Individual;Inherited;Investigation;Language Disorders;Length;Link;Magnetic Resonance Imaging;Measurement;Mediating;Methylation;Micro Array Data;Molecular;Mutation;Nerve Degeneration;Neuroanatomy;Neurocognitive;neuroimaging;neuromuscular;Neuromuscular Diseases;neuroprotection;Pathologic;Pathology;Patients;Pattern;Phenotype;precision medicine;Primary Progressive Aphasia;Progressive Aphasias;promoter;protein TDP-43;recruit;Regional Anatomy;Risk;RNA;RNA-Binding Proteins;Scanning;Single Nucleotide Polymorphism;social deficits;Source;specific biomarkers;Structure;superoxide dismutase 1;Syndrome;Tars;Therapeutic Intervention;Thick;transcriptomics;variable region gene;Variant;white matter

PROJECT_TITLE: Transcriptomic Approaches to TDP-43 Pathology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

PI_NAMEs: IRWIN, DAVID JOHN (contact)

PROJECT_TERMS: 3-Dimensional;3D Print;Affect;Aging;Alzheimer's Disease;Autopsy;behavioral variant frontotemporal dementia;Biological Markers;biomarker development;biomarker validation;Biometry;Brain;brain tissue;Cells;cellular pathology;cerebral atrophy;Clinical;Clinical Trials;Complex;connectome;Custom;Data;Databases;Dementia;Development;Diagnosis;diagnosis standard;Diffusion Magnetic Resonance Imaging;digital;Disease;disease model;Disease Progression;ex vivo imaging;Exclusion;Fiber;frontotemporal degeneration;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional Magnetic Resonance Imaging;Genetic;Goals;Graph;graph theory;gray matter;Heterogeneity;Histology;Histopathology;Human;Image;image guided;imaging biomarker;in vivo;Language;Length;Life;Magnetic Resonance Imaging;Maps;Measures;Mediating;Methods;Microscopic;Microtomy;Modality;Modeling;Molds;Nerve Degeneration;Neurocognitive;neurodegenerative dementia;neuroimaging;neuroimaging marker;neuropathology;novel;novel strategies;Pathology;Pathway Analysis;Pathway interactions;Patients;Pattern;prospective;protein TDP-43;recruit;Resolution;Sampling;Symptoms;Syndrome;targeted treatment;tau Proteins;Tauopathies;Tissues;tractography;Translating;Validation;white matter;White Matter Disease;Work

PROJECT_TITLE: Pathology-guided 7T neuroimaging biomarker in FTLD-TDP


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Neutrophils play a critical role in maintaining tissue homeostasis but can also contribute to the progression of diverse diseases (e.g. chronic infections, cancer, cardiovascular disease, autoimmune disease, fibrosis). Modulating neutrophil recruitment or function is a promising strategy for treating these diseases but we must first understand how neutrophils integrate diverse proinflammatory signals into a specific and directed response. This proposal will use a physiologically relevant microfluidic model to identify key signaling molecules that regulate the neutrophil response, providing future therapeutic targets for modulating the neutrophil response.

PI_NAMEs: HIND, LAUREL ERIN (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: 3-Dimensional;Address;antimicrobial;Architecture;Autoimmune Diseases;Behavior;Behavior Therapy;Biology;Blood Platelets;Blood Vessels;Cardiovascular Diseases;Cell Communication;cell type;Cells;chronic infection;Complex;Cues;cytokine;design;Devices;Disease;Disease Progression;Endothelial Cells;Engineering;Environment;Experimental Models;Extracellular Matrix;Extravasation;Fibrosis;Future;Goals;Homeostasis;Human;Immune;In Vitro;in vitro Model;in vivo;Individual;Infection;Inflammation;Inflammatory;inflammatory milieu;Innate Immune Response;interest;Knowledge;Laboratories;Macrophage;Malignant Neoplasms;Microfluidics;migration;Modeling;Molecular;neutrophil;Neutrophil Infiltration;novel;pathogen;Pattern;Pericytes;Physiological;Play;Population;repaired;response;Role;Signal Transduction;Signaling Molecule;Source;Stimulus;therapeutic target;Tissues;Work;wound healing

PROJECT_TITLE: Reconstructing Cell-Cell Interactions in Diverse Inflammatory Environments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Lung;Lung Cancer;Prevention;Rare Diseases;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health;Tuberculosis

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE In settings with limited resources, understanding the potential benefits and costs of various interventions to promote tobacco cessation in HIV care is critical for clinical and public health policy decisions. This project will combine an integrated cost-effectiveness model of tobacco, HIV, and tuberculosis care with tobacco-related findings from a population-based cohort in South Africa to project clinical and economic outcomes and cost- effectiveness of tobacco cessation interventions embedded within HIV care. The overall goal is to promote an evidence-based approach to decisions around the integrated health care and services for the overlapping tobacco, HIV, and tuberculosis epidemics.

PI_NAMEs: REDDY, KRISHNA P (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Accounting;Address;Adult;antiretroviral therapy;Area;Behavior;Behavioral;budget impact;Cardiovascular Diseases;care delivery;care outcomes;Caring;Cause of Death;Clinical;clinical investigation;Clinical Trials;clinically relevant;cohort;Cohort Studies;Collaborations;Communities;comorbidity;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness evaluation;Costs and Benefits;Country;Data;Databases;design;Disease;Economic Burden;economic cost;economic evaluation;economic impact;economic outcome;Effectiveness of Interventions;Epidemic;Epidemiology;Ethics;evidence base;experience;Face;Funding Opportunities;Future;global health;Goals;Guidelines;Health;Health behavior;Health Care Costs;health care service utilization;health economics;health organization;Health Policy;Health Services;Healthcare;high risk;HIV;HIV/TB;Income;innovation;Institution;integrated care;International;Intervention;intervention effect;Investigation;Life;Life Expectancy;Logistics;low and middle-income countries;Malignant Neoplasms;Methods;Modeling;models and simulation;multidisciplinary;Natural History;novel;Outcome;Persons;Policies;population based;Prevention;Productivity;Public Health;Publishing;Recording of previous events;Reporting;Research;Research Personnel;Resources;response;Risk;Risk Reduction;Scientist;Services;social;South Africa;South African;Structure;synergism;Time;Tobacco;tobacco cessation intervention;tobacco control;Tobacco smoke;Tobacco smoking behavior;Tobacco use;Tobacco Use Cessation;Training;Tuberculosis;tuberculosis treatment;United States National Institutes of Health

PROJECT_TITLE: Tobacco Use and Cessation, HIV, and TB in South Africa: Clinical and Economic Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AARR-G(55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: GROSSMAN, MURRAY  (contact)

PROJECT_TERMS: Aging;Anterior;Area;Atrophic;Autopsy;Cells;Characteristics;Clinical;Clinical Research;Communities;Complex;connectome;density;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Disease Marker;Disease Progression;frontotemporal degeneration;Frontotemporal Lobar Degenerations;Goals;Graph;Heterogeneity;Image;Impairment;in vivo;Individual;Inferior;innovation;Linguistics;Link;longitudinal analysis;Magnetic Resonance Imaging;Measures;Methods;multimodality;mutation carrier;Names;Network-based;novel;Pathologic;Pathology;Pathway Analysis;Pattern;Primary Progressive Aphasia;Progressive Aphasias;Progressive Disease;Publishing;Regional Anatomy;screening;Semantics;serial imaging;Series;Spectrum Analysis;Speech;Syndrome;tau Proteins;Testing;treatment trial;ultra high resolution;Variant;white matter;Work

PROJECT_TITLE: Connectome and 7T MRI reflect pathologic networks in sporadic primary progressive aphasia and familial FTLD


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Mental Health;Mental Illness;Physical Activity;Prevention;Rehabilitation;Substance Misuse;Women's Health Research

ORG_NAME: BUTLER HOSPITAL (PROVIDENCE, RI)

PHR: Public Health Narrative  This project will contribute much-needed knowledge on the role of physical activity in reducing alcohol use, depressive symptoms and negative mood, and increasing fitness in women with depression and alcohol use disorder (AUD). We expect that the results of this study will establish the LPA+Fitbit intervention as efficacious for women with AUD and depression in early recovery. If the efficacy of the LPA+Fitbit intervention can be established, depressed women with AUD will have a valuable adjunct to traditional alcohol treatment that is acceptable, flexible and employs an alternate coping strategy during early recovery, when relapse risk is highest.

PI_NAMEs: ABRANTES, ANA M (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Abstinence;acceptability and feasibility;addiction;Addictive Behavior;Affect;Aftercare;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol use disorder;Alcohols;Behavioral;cardiorespiratory fitness;Child Care;coping;Coping Skills;cost;Counseling;Coupled;craving;Data;Depressed mood;depressive symptoms;drinking;Dropout;early alcohol use;Ecological momentary assessment;Educational Intervention;efficacy testing;Emotions;exercise intervention;fitbit;fitness;flexibility;follow-up;Goals;Health;Health education;improved;Individual;interpersonal conflict;Intervention;Knowledge;Life Style;Measures;Mediating;medical specialties;men;Mental Depression;Mental disorders;mobile application;Monitor;negative affect;negative emotional state;negative mood;novel;Outcome;Participant;Physical activity;Physical assessment;Play;Population;positive emotional state;Precipitating Factors;pressure;primary outcome;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;Recovery;reduced alcohol use;Relapse;relapse patients;relapse risk;Reporting;response;Role;secondary outcome;Self Efficacy;Shame;social;social stigma;Stressful Event;Technology;Telephone;Testing;Time;treatment effect;Woman;Work

PROJECT_TITLE: Testing the Efficacy of a Technology-Supported Lifestyle Physical Activity Intervention Among Women with Depression in Alcohol Treatment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

PI_NAMEs: MASSIMO, LAUREN M (contact)

PROJECT_TERMS: Aging;Anatomy;arterial spin labeling;Atrophic;Behavioral;behavioral variant frontotemporal dementia;Biological;Brain;Brain region;burden of illness;Cells;Cerebrovascular Circulation;Cerebrum;Clinical;clinical diagnosis;Clinical Management;clinical predictive model;Clinical Trials;Cognitive;cognitive reserve;cohort;Complex;Data;density;Disease;Disease Progression;Education;emotion regulation;Emotional disorder;executive function;Family;flexibility;frontotemporal degeneration;Frontotemporal Lobar Degenerations;Functional Magnetic Resonance Imaging;Gene Frequency;Genes;Genetic;Genetic Determinism;Genetic Predisposition to Disease;Genetic Variation;Goals;Graph;gray matter;Heterogeneity;Histopathology;Image;Impaired cognition;Impairment;Individual;Knowledge;Leisure Activities;Life Expectancy;Life Style;lifestyle factors;Link;Magnetic Resonance Imaging;Measures;Modeling;Moderate Activity;network models;neural;neural network;Neuroanatomy;Neurodegenerative Disorders;Neurons;neuropathology;novel;Occupational;Occupations;Pathologic;Pathology;Patients;Performance;Personality;Phase;predictive modeling;Probability;prognostic;Property;protein TDP-43;Psyche structure;Regional Anatomy;resilience;Resources;Risk;risk variant;Role;Single Nucleotide Polymorphism;Source;Specificity;support network;Syndrome;tau Proteins;Variant;white matter;Work

PROJECT_TITLE: Anatomic mechanisms of resilience and genetic susceptibility in TDP-related disorders


ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE – Overall The Duke/University of North Carolina (UNC) Alzheimer’s Disease Research Center (Duke/UNC ADRC) is a collaboration of leading researchers in aging and Alzheimer’s disease. The Center’s primary objective is to catalyze and support research and innovation that will ultimately reduce the prevalence and impact of Alzheimer’s disease and related dementias. Leveraging the diversity of Eastern North Carolina and our strong scientific environment, we will enable novel research to identify opportunities to intervene in the years before Alzheimer’s disease symptoms arise and to reduce racial and urban/rural disparities associated with dementia.

PI_NAMEs: GARDEN, GWENN A;WHITSON, HEATHER E. (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Advocacy;Affect;Age;age effect;age related changes;Age related comorbidities;Age-associated memory impairment;Aging;aging process;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Award;Back;biobank;Bioinformatics;Biological;Biological Aging;Biological Markers;Biological Models;Biology of Aging;Biomedical Research;Brain;Caliber;Cardiovascular Diseases;Caregivers;Caring;Catchment Area;Clinical;clinical center;cohort;Collaborations;Collection;Communication;Communities;Community Outreach;comorbidity;Complex;Coupled;Creativeness;Data;Data Analyses;data curation;data integration;data management;Data Management Resources;Data Set;data sharing;Dementia;design;Development;Disease;disease phenotype;Disparity;Doctor of Philosophy;Down's Syndrome;Education;education research;Elderly;Elements;Enrollment;Environment;Event;experience;Faculty;Family;forging;Fostering;Funding;Future;Generations;Geroscience;Goals;Health;Health Services;Heritability;human data;Image;imaging facilities;improved;Individual;Inflammation;Information Dissemination;Infrastructure;innovation;Institution;investigator training;Investments;Joints;K-Series Research Career Programs;Leadership;life span;Link;Liquid substance;Longitudinal cohort;Mediating;meetings;Mentors;Metabolism;middle age;minority communities;Minority-Serving Institution;Modeling;Neurologist;Neurology;neuropathology;North Carolina;novel;outreach;Participant;Pathology;Pathway interactions;Patients;Persons;Phenotype;Pilot Projects;Positioning Attribute;pre-clinical;Prevalence;Prevention;programs;proteostasis;Race;recruit;Registries;Research;Research Activity;Research Personnel;Research Support;Resources;Role;Rural Community;rural disparities;Schools;Sensory impairment;Services;statistics;Surveys;Symptoms;Syndrome;Testing;Tissue Banks;Training;Training Programs;translational pipeline;Translations;United States National Institutes of Health;Universities;Update;Vision;volunteer;Work

PROJECT_TITLE: Duke/UNC Alzheimer's Disease Research Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: WHITSON, HEATHER E. (contact)

PROJECT_TERMS: Achievement;Advisory Committees;age related changes;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Ancillary Study;Area;Awareness;Biological Markers;Caliber;Catchment Area;Clinical;Cohort Studies;Collaborations;Communication;Communities;Creativeness;Data;data management;data sharing;Development;Directories;Discipline;Doctor of Philosophy;Documentation;education research;Effectiveness;Ensure;Evaluation;Event;Expenditure;experience;Faculty;Fostering;Funding;Grant;Home;Infrastructure;innovation;Institution;interest;International;Leadership;life span;meetings;member;Monitor;Needs Assessment;Neurology;neuropathology;North Carolina;Outcome;outreach;Positioning Attribute;Process;programs;Publications;recruit;Research;Research Personnel;Resources;response;Role;Scientist;Services;Structure;success;United States National Institutes of Health;Update;web site

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Proper expression of information in genes is absolutely critical for correct cellular function; defects in any of the reactions involved in gene expression can have catastrophic consequences for the cell. Genes contain long stretches of interrupting information (introns) that must be removed by the cellular machinery in order for that information to be properly expressed, a process called RNA splicing; mutations that cause defects in these mechanisms are a leading cause of a variety of human diseases—from neurodegeneration and blindness to all known cancers. The focus of our work is to understand the molecular details underlying RNA splicing and its regulation, as this is a crucial step toward understanding the etiology of human diseases and, ultimately, for developing tools to treat them.

PI_NAMEs: JOHNSON, TRACY L (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Affect;Blindness;Catalysis;Cell Physiology;Cells;Chromatin;Cryoelectron Microscopy;Data;Defect;Disease;Etiology;Eukaryota;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;human disease;Interruption;Introns;Lead;Malignant Neoplasms;Messenger RNA;Molecular;Mutation;Nerve Degeneration;Process;Reaction;Regulation;Ribonucleoproteins;RNA Processing;RNA Splicing;RNA, Messenger, Splicing;Spliceosome Assembly Pathway;Spliceosomes;Stretching;Structure;tool;Toxic effect;Transcript;Work

PROJECT_TITLE: Mechanisms of messenger RNA splicing and RNA processing regulation

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Genetics;Immunotherapy;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: In this proposal, we will study how parental (H3-H4)2 tetramers, the primary carrier of epigenetic modifications, are assembled into nucleosomes following DNA replication, the first step in the inheritance of higher-order chromatin structures. Moreover, we will determine how deficiencies in this process lead to reactivation of endogenous retrovirus (ERVs), which is linked to increased response of cancer cells to immunotherapy. Therefore, the proposed studies will not only provide an unprecedented insight into epigenetic inheritance, a critical but poorly understood cellular process, but will also shed light on an epigenetic mechanism for boosting the response of cancer cells to immunotherapy.

PI_NAMEs: ZHANG, ZHIGUO  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Binding Proteins;cancer cell;Cell Cycle;Cell Physiology;Cells;Chromatin;Complex;Coupled;daughter cell;DNA;DNA biosynthesis;DNA replication fork;Elements;Endogenous Retroviruses;Epigenetic Process;Euchromatin;Eukaryotic Cell;genome integrity;Genomic DNA;Heterochromatin;Higher Order Chromatin Structure;histone modification;Histones;Immunotherapy;Inherited;insight;Lead;Link;Methods;Modification;Molecular;Mouse Embryonic Stem Cells;novel;Nucleosomes;Peptide Sequence Determination;Process;Repression;response;S phase;transmission process;Yeasts

PROJECT_TITLE: Mechanism of Epigenetic Inheritance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Genetics;Human Genome;Microbiome;Natural Products

ORG_CITY: CHAMPAIGN

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Natural products continue to be the most valuable source of drug leads, however, the traditional process of discovering natural products is exceedingly inefficient. This project will accelerate the discovery process by combining the power of genome-mining and reactivity-based screening to rapidly locate novel structures of basic scientific and biomedical interest.

PI_NAMEs: MITCHELL, DOUGLAS ALAN (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acceleration;Algorithms;Amphotericin;Anabolism;Animals;anti-fungal agents;Ants;Bacteria;Bacterial Genome;Bacterial natural products;Big Data;Binding;Biochemical;Biochemistry;Bioinformatics;bioinformatics tool;Biological;Biological Assay;Biology;Catalogs;Cells;Chemicals;Chemistry;Cholesterol;Classification;Communities;crosslink;Data;Databases;Deposition;Development;Drug Kinetics;Educational process of instructing;Emerging Technologies;Enzymes;Ergosterol;Exhibits;Explosion;Family;fungus;Future;Genbank;Gene Cluster;Gene Structure;Genetic;Genome;genome sequencing;genomic data;Genomics;Geography;Human;human disease;Iceberg;improved;in vivo;innovation;Insecta;interest;Invertebrates;Knowledge;Length;Life;Macrolides;Malignant Neoplasms;member;Membrane;Metabolic;metagenome;Metagenomics;Methods;Microbe;microbial;microbiome;microbiome sequencing;Mining;Modernization;Molecular;Molecular Probes;Molecular Structure;Mus;Natural product discovery;Natural Products;Natural Products Chemistry;Natural Source;Nematoda;novel;Open Reading Frames;Pathway interactions;peptide natural products;Peptides;Pharmaceutical Preparations;Planet Earth;Polyenes;polyketides;Process;Research Personnel;Resources;Ribosomes;S-Adenosylhomocysteine;S-Adenosylmethionine;scaffold;screening;Shapes;Soil;Source;Specificity;Sterols;Streptomyces;Structure;symbiont;synthetic biology;Taxonomy;tool;Toxic effect;user-friendly;virtual

PROJECT_TITLE: Genomics Accelerated Natural Product Discovery


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: O'BRIEN, RICHARD J (contact)

PROJECT_TERMS: Address;adjudication;African American;Age;age related;aged;Aging;aging biomarker;aging mechanism;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;amyloid imaging;apolipoprotein E-4;Autopsy;Biological;Biological Markers;Black race;Blood;Blood specimen;Brain;brain magnetic resonance imaging;Brain scan;brain tissue;Cataloging;Cerebrospinal Fluid;Cessation of life;Clinical;Clinical Trials;Cognition;Cognition Disorders;Cognitive;cohort;Collaborations;Collection;Communities;comorbidity;comparison group;Consensus;Consent;Data;data management;Data Set;data sharing;Dementia;design;Development;Diagnosis;digital measure;Disease;Disease Progression;Disparity;Education;education research;Enrollment;Ensure;Epigenetic Process;ethnic minority;Evaluation;experience;Family history of;Female;follow-up;Funding;Genetic Risk;Genotype;Goals;Image;Impaired cognition;Individual;innovation;Institution;life span;Link;Longitudinal cohort;male;Measures;Medical;member;Memory Disorders;Menopause;metabolomics;Minority Groups;Mission;Modality;Molecular;Motor;MRI Scans;Neurologic;neuropathology;Neuropsychology;novel;novel marker;outreach;Participant;Pathogenesis;Pathologic;Pathology;portability;Positron-Emission Tomography;Prevalence;Procedures;Process;prospective;Protocols documentation;Qualifying;racial minority;Recovery;recruit;Research;Research Activity;Research Personnel;Resource Sharing;Resources;Retina;retinal imaging;Role;rural Americans;Rural Population;Sampling;Sensory;Specimen;Spinal Puncture;statistics;symposium;tau Proteins;Testing;Time;Visit;volunteer

PROJECT_TITLE: Clinical Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Pediatric;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative A genetic abnormality is thought to underlie a substantial portion of CHD, but the identity of the abnormalities has not been identified in 50% of affected patients. This proposal seeks to apply state-of-the-art genomic technology to a large cohort of CHD patients recruited to the PCGC program and identify the genetic cause of CHD, and then to link the genetic findings to actionable outcomes to improve care of patients with CHD.

PI_NAMEs: BRUECKNER, MARTINA  (contact);GRUBER, PETER J;LIFTON, RICHARD P

PROGRAM_OFFICER_NAME: SCHWARTZ, BRYANNA NICOLE

PROJECT_TERMS: Address;Adult;Affect;Aneuploidy;cancer risk;Cardiac;Charge;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Cilia;Clinical;clinical care;Clinical Data;Code;cohort;Common Ventricle;Communities;comorbidity;Complex;Computerized Medical Record;Congenital Abnormality;congenital heart abnormality;Copy Number Polymorphism;cost effective;Costs and Benefits;Coupled;Coupling;Data;data management;data mining;Databases;de novo mutation;Development;Disease Outcome;Evolution;exome;exome sequencing;Functional disorder;gene discovery;Gene Mutation;Genes;Genetic;genetic architecture;Genetic Diseases;genetic disorder diagnosis;Genetic Heterogeneity;genetic variant;Genome;genome browser;genome sequencing;genomic data;Genomics;Genotype;Goals;Heterogeneity;Human Resources;improved;Infant;Informatics;Inherited;Internet;Introns;Link;Medical Records;Medical Societies;Molecular Abnormality;Morbidity - disease rate;Mutation;novel;novel strategies;Outcome;outreach;Participant;participant enrollment;Patient Care;Patient Recruitments;Patients;Pediatric cardiology;Phenotype;phenotypic data;Population;proband;programs;Public Health;rare variant;Recontacts;Records;recruit;Role;Structure;success;Surgeon;Survivors;targeted sequencing;Technology;Thoracic Surgeon;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Congenital Heart Disease Genetics and Clinical Outcomes


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Almost all our everyday actions, such as driving a car or riding a bike, necessitate flexible multi-tasking. While considerable work has examined how the brain’s distributed motor network controls consistent movements in an invariant environment, the mechanisms that allow for flexibility in movement control remain unknown. In this project, I study the flexible production of multiple distinct reaching movements in mice to uncover fundamental principles by which the brain’s distributed motor system governs flexibility in movement control and shed light how these mechanisms can dysfunction in disease.

PI_NAMEs: LEMKE, STEFAN  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Address;Angelman Syndrome;Animal Model;Animals;Area;autism spectrum disorder;Automobile Driving;Basal Ganglia;Behavior;Behavioral;Behavioral Model;behavioral phenotyping;Brain;Brain Diseases;Cerebellum;control theory;Disease;Environment;flexibility;Functional disorder;Genetic Diseases;Goals;Hand;Impairment;imprint;insight;Knockout Mice;Left;Lesion;Light;Link;Manuals;model design;Modeling;Motor;motor control;Motor Cortex;motor deficit;Motor Skills;mouse model;Movement;multitask;Mus;Muscle;Nervous System Disorder;neural;Neural Network Simulation;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;neurophysiology;neuropsychiatric disorder;neuroregulation;Obsessive-Compulsive Disorder;Pattern;Policies;Population;Problem Solving;Production;recurrent neural network;restoration;Site;Stroke;System;targeted treatment;Thalamic structure;Translating;transmission process;UBE3A gene;Work

PROJECT_TITLE: Understanding the Distributed Control of Flexible Behavior

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: LUTZ, MICHAEL WILLIAM (contact)

PROJECT_TERMS: age related;age related changes;Alzheimer's Disease;Alzheimer's disease related dementia;Big Data;Biocompatible Materials;Bioinformatics;Biological;Biological Markers;Clinical;Clinical Data;cohort;Collaborations;Communities;Consent Forms;Consultations;Custom;Data;Data Analyses;data cleaning;Data Collection;data communication;Data Coordinating Center;data format;data integration;data management;Data Set;data sharing;Databases;Dementia;design;Development;Disease;Education;education research;Ensure;Epidemiology;experience;Faculty;Genetic;genetic analysis;genetic variant;Genomics;Gerontology;Grant;Image;Infrastructure;innovation;interest;large datasets;large scale data;Leadership;life span;Measurement;Mediating;Mentors;metabolomics;Methodology;Methods;Modeling;multimodality;neuroimaging;Participant;Prevention;Proteomics;Publishing;Quality Control;query tools;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Sampling;Schedule;Scientist;Security;Specimen;Statistical Data Interpretation;Statistical Study;statistics;System;transcriptomics;United States National Institutes of Health;user-friendly;Work

PROJECT_TITLE: Data & Stats Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Recovery Support Services;Rehabilitation;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative Alcohol use disorder (AUD) is common among patients in the intensive care unit (ICU) but very few ICU survivors with AUD are effectively connected to alcohol treatment programs. The goal of this project is to facilitate the entry of ICU survivors with AUD into alcohol treatment by creating, refining, and piloting a peer-narrated virtual tour of an alcohol treatment program which would immediately and virtually transport a patient to a treatment facility while hearing the narrative of a peer in recovery. After rigorous development and testing, the end result will be a video patient decision aid for ICU survivors with AUD that can be expanded to various treatment options in the Denver area for a larger pragmatic effectiveness trial.

PI_NAMEs: HILLS-DUNLAP, KELSEY R (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Abstinence;acute care;addiction;Address;Admission activity;adverse outcome;Advisory Committees;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol use disorder;Alcohols;Area;Behavior;Benchmarking;career;Caring;Cessation of life;clinical practice;Clinical Sciences;Colorado;Counseling;Critical Care;Critical Illness;Data;Decision Aid;Decision Making;Dependence;Development;drinking;effectiveness study;Ensure;Environment;experience;Familiarity;Feedback;Fellowship Program;Future;Goals;Health behavior change;Health Services;Health Services Accessibility;Hearing;hospital readmission;Hospitalization;Hospitals;innovation;Inpatients;Insurance Coverage;Intensive Care Units;Intention;interest;Intervention;Interview;Knowledge;Learning;Link;long term recovery;Medical;Medicine;Mentors;Mentorship;Methodology;metropolitan;Motivation;multidisciplinary;Narration;National Institute on Alcohol Abuse and Alcoholism;novel;Patient Admission;patient engagement;patient population;Patients;peer;pilot test;pilot trial;pragmatic trial;Prevalence;Process;programs;prototype;Qualitative Methods;Recovery;Rehabilitation therapy;Reporting;Research;Research Methodology;Research Personnel;Risk;skills;social separation;Structure;Survivors;Testing;Thinking;Time;treatment center;treatment program;Universities;virtual;virtual intervention;virtual patient;virtual therapy;Wait Time;Waiting Lists;Work

PROJECT_TITLE: Development of a Novel Peer-Narrated Virtual Patient Decision Aid for Entry into Alcohol Treatment for ICU Survivors with Alcohol Misuse


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: PSYCHIATRY

PHR: Understanding causal relationship between one's own actions and external events is human competence critical for building veridical representation of, and selecting desired actions in the complex world. The proposed research takes an integrative approach that combines innovative behavioral paradigm with multi-scale neural recordings, perturbations and computational modeling, to test novel hypotheses regarding the role of heterogeneous dynamics of memory in the primate prefrontal cortex in causal inference. Causal reasoning is often disrupted in the patients with psychiatric disorders and the results from the proposed study will contribute to understanding not only the foundation of human high-order cognition, but also the prefrontal pathophysiology of psychiatric symptoms.

PI_NAMEs: SEO, HYOJUNG  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Address;Animals;Behavioral Paradigm;Brain;caudate nucleus;causal model;Cognition;Competence;Complex;Computer Models;Corpus striatum structure;designer receptors exclusively activated by designer drugs;Dimensions;Electrodes;Elements;Eligibility Determination;Event;experience;Feedback;flexibility;Foundations;Functional disorder;Goals;Human;Image;Individual;innovation;insight;Learning;Lesion;Ligands;Link;Memory;Mental disorders;Modeling;Monkeys;neural;Neural Network Simulation;neuroimaging;neuromechanism;Neurons;Neurosciences Research;neurotransmission;novel;Outcome;Patients;Pattern;Population;Positron-Emission Tomography;Prefrontal Cortex;Primates;Process;psychiatric symptom;psychotic symptoms;receptor expression;Research;Role;Stream;Structure;temporal measurement;Testing;theories;Time;Time Series Analysis;time use;Update;Visualization;Work

PROJECT_TITLE: Corticostriatal mechanisms of causal inference and temporal credit assignment.


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Osteoporosis;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: NARRATIVE SUMMARY Osteoporosis is a major disease of aging that has origins in childhood since failure to achieve optimal bone accretion during growth results in suboptimal peak bone mass and bone fragility in older adulthood. Osteoporosis has a strong heritable component, and pediatric studies may be more effective in distilling the genetic component in this complex disease, because duration of environmental exposure has been less. Utilizing existing data from the NICHD Bone Mineral Density in Childhood Study, we will use advanced techniques to extract new information about bone quality and structural strength, and bone-related body composition, and apply high resolution `3D Genomics' and CRISPR based techniques to pinpoint causal genetic variants and corresponding effector gene(s) to deepen our understanding of bone accretion during this critical phase of the life cycle.

PI_NAMEs: GRANT, STRUAN F A;ZEMEL, BABETTE S (contact)

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: 3-Dimensional;Address;Adipose tissue;Adult;Affect;Age;aging related disease;ATAC-seq;Body Composition;bone;Bone Density;Bone Development;bone fragility;bone mass;Bone Mineral Contents;bone quality;bone strength;Cell Line;Cell model;cell type;Cells;Child;Childhood;Chromatin;chromosome conformation capture;Chromosome Mapping;clinical development;clinically relevant;Cohort Studies;Complex;Computer software;CRISPR/Cas technology;Data;data quality;Development;Dimensions;Disease;Dual-Energy X-Ray Absorptiometry;Elements;Enhancers;Environmental Exposure;Epigenetic Process;Ethnic Origin;Etiology;Failure;Fatty acid glycerol esters;functional genomics;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene function;Genes;Genetic;genetic architecture;Genetic Determinism;Genetic study;genetic variant;genome wide association study;genome-wide;Genomics;Genotype;Growth;Health;Heritability;Hip region structure;Human;Image;indexing;innovation;insight;Institution;knock-down;Knowledge;Laboratories;Life;Life Cycle Stages;Location;longitudinal design;Measures;Mesenchymal Stem Cells;Methods;Muscle;Musculoskeletal;National Institute of Child Health and Human Development;novel;older adult;Osteoblasts;Osteoporosis;pediatric patients;Phase;Phenotype;prevent;progenitor;promoter;Public Domains;Reporting;Resolution;Resources;Sentinel;shape analysis;Shapes;Signal Transduction;skeletal;Skeletal Development;Skeleton;Small Interfering RNA;Techniques;Tissues;Trabecular Bone Score;trait;transcriptome sequencing;Variant

PROJECT_TITLE: Genomics of bone and body composition traits in children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-K(02)]


PI_NAMEs: WANG, SHIH-HSIU JERRY (contact)

PROJECT_TERMS: Acetylation;Age;age related;age related changes;aged;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Animal Model;Autopsy;Behavioral;biobank;Biological;Biological Markers;Blood;Brain;brain cell;brain tissue;Cell Nucleus;cell type;Cells;Cerebrospinal Fluid;Cessation of life;Chromatin;Clinical;Cognitive;Collaborations;Collection;Communication;Communities;Complement;Consensus;Consent;Consultations;Data;data management;Data Set;data submission;Databases;design;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Diagnostic Services;DNA;Doctor of Philosophy;education research;epigenomics;Eye;Family;Funding;Genetic;Goals;Guidelines;Impaired cognition;improved;Individual;Infrastructure;innovation;investigator training;Laboratories;Leadership;life span;Management Information Systems;Maryland;Medical Examiners;metabolomics;Metadata;minority subjects;multiple omics;Needs Assessment;Neuroanatomy;Neurodegenerative Disorders;neuropathology;Participant;Pathology;Patients;Phenotype;programs;Protocols documentation;racial diversity;Reporting;repository;Research;Research Personnel;Research Project Grants;Research Support;Research Technics;Resources;Role;Sampling;Scientist;Services;Specimen;statistics;symposium;tau Proteins;Tauopathies;Tissues;Training;Training Programs;transcriptomics;Universities;Update;Work

PROJECT_TITLE: Neuropathology Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Scientific evidence suggests racially and ethnically diverse women who use drugs are disproportionately impacted by HIV transmission risk and intersectional stigma and have low levels of pre-exposure prophylaxis awareness and uptake. Mobile health (mHealth) interventions and interventions that target intersectional stigma have the potential to increase HIV prevention service engagement, but few mHealth interventions tailored specifically toward racially diverse WWUD have been developed. The proposed training and research aims would address this gap by developing an mHealth intervention targeting HIV prevention service engagement and intersectional stigma among racially and ethnically diverse WWUD, and would uniquely position me as one of few health behavior interventionists specializing in intersectional stigma and mHealth interventions for WWUD within the Division of Infectious Diseases and Global Public Health at the University of California San Diego (UCSD).

PI_NAMEs: MEYERS-PANTELE, STEPHANIE ALICE (contact)

PROJECT_TERMS: Address;Adherence;Adopted;Adoption;Affect;African American;AIDS prevention;Awareness;base;Behavior Therapy;Biological;Black race;California;career;Characteristics;cis-female;Clinic;Communicable Diseases;Communities;community organizations;Consolidated Framework for Implementation Research;Coping Skills;County;Data;design;Development;Discrimination;disparities in women;Drug usage;Drug user;Educational workshop;Eligibility Determination;Employee;Environment;Epidemic;ethnic diversity;experience;Feedback;Fostering;Future;Gender;Goals;hands on research;Health;Health behavior;health care availability;health care service;health equity;HIV;HIV disparities;HIV Infections;HIV Seronegativity;HIV/STD;Hybrids;implementation science;improved;Incidence;Individual;informant;Instruction;intersectionality;Intervention;Interview;Knowledge;Latina;Link;Measures;Medical;member;men;Mentored Research Scientist Development Award;Mentors;Methods;mHealth;mhealth interventions;Morality;motherhood;novel;opioid use;Participant;Patient Self-Report;Population;Positioning Attribute;pre-exposure prophylaxis;Prevention Research;prevention service;Procedures;Process;Productivity;Provider;Public Health;Qualitative Methods;Race;racial diversity;Randomized;Randomized, Controlled Trials;Research;Risk;Scientist;secondary analysis;service engagement;Services;skill acquisition;skills;social norm;social stigma;Social support;Stimulant;substance use;Suggestion;Testing;theories;therapy design;therapy development;Training;transmission process;United States Dept. of Health and Human Services;Universities;uptake;usability;user centered design;Violence;Woman

PROJECT_TITLE: LOTUS: An mHealth Intervention to Improve HIV Prevention Service Engagement and Intersectional Stigma among Racially Diverse Women Who Use Drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-V(02)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: HADLEY

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE The ongoing international effort to generate a loss of function knock-out (KO) allele for every gene in mouse is well underway. However, 12% of homozygous knock-out mice will be embryonic lethal prior to E9.5 and there is no current plan to analyze them. During the first award period we have capitalized on the immense resource that these knock-out alleles provide by characterizing more than 100 novel early embryonic lethal phenotypes. Here we propose to continue our streamlined assessment of up to 150 knock out alleles. These studies will enhance our understanding of the initial stages of development of early cell lineages, multiple organ progenitors as well as advance our understanding of human disease by identifying specific gene functions during critical developmental events. Our proposal fills the existing gap in phenotyping efforts and will maximize the productivity of the IMPC and KOMP efforts in generating KO alleles at every gene.

PI_NAMEs: MAGER, JESSE  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Address;Adult;Alleles;Award;Back;blastocyst;Categories;Cell Lineage;Cells;Charge;Classification;cohort;Communities;Complement;Congenital Abnormality;Data;Databases;Defect;Development;Disease;early embryonic stage;Embryo;Embryonic Development;Endoderm;Ensure;Epiblast;Event;experience;Failure;Fertilization;First Independent Research Support and Transition Awards;Fostering;gastrulation;gene function;Generations;Genes;Genetic;genome annotation;Goals;Heterozygote;human disease;implantation;Individual;interest;International;Investments;knock out mouse project;Knock-out;knockout gene;Knockout Mice;knowledge base;Link;loss of function;mammalian genome;Morphology;mouse genome;Mus;mutant;Nature;novel;Organ;Organogenesis;Pathway interactions;Phenotype;phenotypic data;preimplantation;Production;Productivity;progenitor;programs;Proteins;Publishing;Recovery;Regenerative Medicine;Research;Resources;Sorting;Specific qualifier value;Standardization;stem cell biology;success;Techniques;Training;United States National Institutes of Health;Work;zygote

PROJECT_TITLE: Streamline assessment of early lethal phenotypes in the mouse

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: WELSH-BOHMER, KATHLEEN ANNE (contact)

PROJECT_TERMS: Address;Adult;Advocacy;Advocate;African American;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;American;American Indians;Area Health Education Centers;Award;Awareness;bilingualism;brain health;Brain Health Registry;brain research;bridge program;Caregiver support;Cities;Clinical;Clinical and Translational Science Awards;Clinical Research;Cognitive;Communities;community advisory board;community engagement;Community Outreach;Community Participation;Community Practice;Dedications;Dementia;design;Diagnosis;digital technology;Education;Education and Outreach;education research;Electronics;empowerment;Event;experience;Family;family support;Feedback;follow-up;Foundations;Funding;Geriatrics;Goals;Group Meetings;Health Services Accessibility;Health system;Hispanic Americans;Hispanic Populations;Impaired cognition;improved;interest;Intervention;Investigation;Learning;life span;Lumbee tribe;member;Memory;Methods;middle age;Newsletter;North Carolina;novel;outreach;outreach program;Participant;Pattern;Physicians;Population Heterogeneity;Primary Care;programs;Provider;Race;recruit;Registries;Research;Resources;screening;social media;Support Groups;Surveys;tool;Training;Translating;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;Update;virtual;volunteer;Work

PROJECT_TITLE: ORE Core


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Our preliminary data suggest that the transcription factor ETS2 plays a protective role in response to myocardial ischemia/reperfusion injury. We will determine the underlying mechanisms and downstream targets and interactors of the ERK1/2/ETS2 cascade that mediate this cardioprotective response.

PI_NAMEs: GILLETTE, THOMAS G;HILL, JOSEPH A (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acute;Apoptotic;Binding;Calcineurin;Cardiac;Cardiac Myocytes;cardioprotection;Cell Death;cell growth;cell injury;ChIP-seq;Connexin 43;Coronary;Coronary Arteriosclerosis;Data;Development;ETS2 gene;Extracellular Signal Regulated Kinases;Family;Future;gain of function;gap junction channel;Gene Expression;Gene Targeting;Genes;Genetic Transcription;genome-wide;Growth;Heart;Heart failure;heart failure with reduced ejection fraction;Heart Hypertrophy;Hypertrophy;Immunoprecipitation;In Vitro;in vivo;Injury;Ischemia;ischemic injury;Ischemic Preconditioning;Ligation;Link;loss of function;MAP2K1 gene;MAPK3 gene;Mass Spectrum Analysis;Mediating;member;Mitogen-Activated Protein Kinase Kinases;Mitogen-Activated Protein Kinases;Modeling;Molecular;Morbidity - disease rate;mortality;Myocardial Infarction;Myocardial Reperfusion Injury;Myocardium;novel;nuclear factors of activated T-cells;Pathogenesis;Pathologic;Pathway interactions;Phosphorylation;Phosphotransferases;Physiological;Play;Predisposition;pressure;promoter;protective pathway;Proteins;recruit;Reperfusion Injury;Reperfusion Therapy;Reporting;response;Risk Factors;Role;Signal Pathway;Signal Transduction;Stress;Testing;transcription factor;transcriptome sequencing;Up-Regulation;Ventricular Remodeling

PROJECT_TITLE: ETS2-dependent control in cardiomyocyte ischemia/reperfusion injury

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Lung;Lung Cancer

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: NARRATIVE Darwinian evolution drives the emergence of resistance to targeted therapy in cancer. We propose to use results from our in vitro evolutionary game assay to parameterize a computer model to allow us to predict 3-dimensional dynamics on clinically relevant timescales. Further, we will extend our assay to function in vivo, allowing the community to test mathematically derived evolutionary therapy hypotheses in preclinical models.

PI_NAMEs: MARUSYK, ANDRIY ;SCOTT, JACOB GARDINIER (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: 3-Dimensional;abiraterone;actionable mutation;Address;anti-cancer research;Antibiotic Resistance;Automobile Driving;Biological;Biological Assay;Biological Process;Biology;Cancer Model;cancer therapy;Clinic;Clinical;Clinical Medicine;clinical translation;Clinical Trials;clinically relevant;Code;Communities;Complex;Computer Models;Data;design;Disease;Ecosystem;Epidermal Growth Factor Receptor;Evolution;Exhibits;experience;Extinction;Favorable Clinical Outcome;Fisheries;Game Theory;Generations;Genes;Glean;Grain;Growth;Heterogeneity;in silico;In Vitro;in vitro Model;in vivo;inhibitor;insight;interdisciplinary approach;Intuition;invention;Life;Literature;Malignant neoplasm of prostate;Malignant Neoplasms;mathematical model;Mathematics;Measurement;Measures;Methods;Modeling;multi-scale modeling;mutant;Mutation;neoplastic cell;New Agents;next generation;Non-Small-Cell Lung Carcinoma;novel;pathogen;Patients;Pesticides;Pharmaceutical Preparations;Phase II Clinical Trials;Phenotype;physical science;Population;Population Heterogeneity;Pre-Clinical Model;pressure;Process;Protein Tyrosine Kinase;Proteins;Qualitative Methods;Race;Refractory;Relapse;Research;Resistance;response;Role;spatiotemporal;success;System;targeted cancer therapy;targeted treatment;Testing;Theoretical model;Theoretical Studies;theories;Therapeutic;Therapeutic Intervention;therapy design;Time;tool;Translating;trial design;tumor;two-dimensional;Tyrosine Kinase Inhibitor;Work

PROJECT_TITLE: Extending experimental evolutionary game theory in cancer in vivo to enable clinical translation: integrating spatio-temporal dynamics using mathematical modeling


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: SONG, ALLEN W (contact)

PROJECT_TERMS: adjudication;Affect;age related;Algorithms;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Area;Biological Markers;Blood;Blood Vessels;Brain;Brain imaging;Caliber;Cells;Classification;Clinical;cohort;Collaborations;Communities;Cortical Column;Data;data acquisition;Data Analyses;data management;Databases;Dementia;density;Detection;Development;Dimensions;Disease;disease diagnosis;Disease Progression;early detection biomarkers;Early Diagnosis;Early identification;education research;Environmental Risk Factor;experience;Faculty;Family;Funding;Genetic Risk;genetic risk factor;Genomics;Goals;high risk population;Human;human old age (65+);human subject;Image;Image Analysis;imaging biomarker;Imaging Device;improved;Individual;innovation;Institution;Investigation;Knowledge;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;metabolomics;Methodology;Modality;Monitor;Nerve Degeneration;Neurodegenerative Disorders;next generation;novel;novel marker;Organ;outreach;Participant;participant enrollment;Patients;Persons;Positron-Emission Tomography;pre-clinical;Prevention;Proteins;Proteomics;Provider;recruit;Research;Research Personnel;Research Project Grants;resilience;Resources;retinal imaging;Sensory;Signal Transduction;Standardization;standardize measure;statistics;Structure;Symptoms;Synapses;tau Proteins;Time;Tracer;Training;ultra high resolution;wearable device;Work

PROJECT_TITLE: Biomarker Core


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Project Narrative Therapeutic nucleic acids have recently gained FDA approval for their ability to silence genes and correct mRNA splicing events, showing their promise for treating traditionally difficult to target disease pathways. Despite their great potential for clinical applications, efforts to develop broadly applicable strategies for their cellular delivery have been limited due to the charged nature of nucleic acids that limits both their cellular uptake and accessibility to their mRNA targets. Here we propose the synthesis of a new class of chemically tunable nucleic acid surfactant conjugates as an innovative way to improve nucleic acid cytosolic delivery along with novel fluorescent surfactant probes that can help us quantify their delivery to enable this promising class of biomolecules to achieve greater clinical application.

PI_NAMEs: ROUGE, JESSICA L (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Achievement;Address;Catalytic DNA;Cells;Charge;Chemicals;clinical application;Clinical Trials;Cytosol;design;Development;Disease;Disease Pathway;DNA;Endocytosis;Endosomes;Event;Future;Gene Silencing;Genes;Hydrophobicity;improved;In Vitro;Individual;innovation;knock-down;Messenger RNA;Molecular;Monitor;nanoparticle;Nature;novel;nucleic acid delivery;nucleic acid-based therapeutics;Nucleic Acids;Pharmaceutical Preparations;programs;Property;Research;RNA Splicing;Role;surfactant;Therapeutic;translational applications;Treatment Efficacy;United States Food and Drug Administration;uptake;Vision

PROJECT_TITLE: Achieving enhanced cytosolic delivery and greater efficacy of therapeutic nucleic acids using DNA-surfactant conjugates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: WALSH, KYLE M (contact)

PROJECT_TERMS: Address;age related changes;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;American Indians;Basic Science;biobank;Biological Markers;Biology of Aging;Capsicum;career;Clinic;Clinical;Clinical Investigator;Clinical Research;Collaborations;Communication;Community Developments;Development;Discipline;Disparity;disparity reduction;Doctor of Philosophy;Education;education research;Educational Curriculum;Educational workshop;Environment;experience;Exposure to;Face;Faculty;Fostering;Future;Goals;health care delivery;health outcome disparity;Historically Black Colleges and Universities;improved;innovation;insight;Institution;interdisciplinary collaboration;interest;Investments;Journals;Knowledge;Learning;life span;Manuscripts;Mediating;Medical;Medical Research;Medical Students;Mentors;Mentorship;multidisciplinary;Neurosciences;next generation;North Carolina;novel;online course;Pathologic;Pathology;Patient Recruitments;Population;Positioning Attribute;Postdoctoral Fellow;posters;Preventive measure;programs;Research;research data dissemination;Research Design;Research Ethics;Research Personnel;Research Support;Research Training;Resources;responsible research conduct;rural healthcare;Sampling;Science;Scientist;Site;Specimen;Statistical Data Interpretation;Students;summer research;symposium;Talents;targeted delivery;Training;Training and Education;training opportunity;Training Programs;Translational Research;Underserved Population;Universities

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cerebrovascular;Immunization;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Delivery of chemotherapeutic agents to the brain and brain tumor by systemic administration is a challenge because of the presence of the blood-brain barrier. We will explore novel antibody-based agents with improved blood-brain barrier penetration efficiency. We expect that completion of this study will lay the foundation for a new class of antibody agents for brain diseases including brain cancer with enhanced therapeutic efficacy and safety profiles.

PI_NAMEs: TSUCHIKAMA, KYOJI  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Antibodies;antibody conjugate;Antibody-drug conjugates;Area;Attenuated;Biodistribution;Blood - brain barrier anatomy;blood-brain barrier penetration;blood-brain barrier permeabilization;Brain;Brain Diseases;Brain Neoplasms;brain parenchyma;Cell Line;Cells;Central Nervous System Diseases;Chemicals;chemotherapeutic agent;Circulation;Clinical;Clinical Research;design;Disease;Drug Delivery Systems;drug development;Drug Kinetics;Drug usage;effective therapy;epidermal growth factor receptor VIII;Extravasation;Foundations;Glioblastoma;immunogenicity;improved;In Vitro;in vivo;intravital fluorescence microscopy;Kinetics;Malignant neoplasm of brain;Measurable;Mediating;Modality;Molecular;Monoclonal Antibodies;mouse model;Mus;Newly Diagnosed;novel;novel therapeutics;patient derived xenograft model;Patients;peptide structure;Peptides;Pharmaceutical Preparations;phase 3 study;Plasma;Property;receptor;Safety;Site;Specificity;stoichiometry;Structure;Systemic Therapy;Technology;Therapeutic;transcytosis;Treatment Efficacy;tumor;Variant;Xenograft procedure

PROJECT_TITLE: Chemical approaches for generating blood-brain barrier-permeable antibody conjugates


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Epilepsy;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Serious Mental Illness

ORG_DEPT: NEUROSURGERY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project narrative Depression is highly prevalent in intractable epilepsy patients undergoing invasive electrophysiological monitoring, which provides a unique opportunity to study highly detailed, multi-areal brain activity across depression states. We propose to combine distributed intracranial electroencephalography recordings, reinforcement learning of decision-making and machine-learning approaches to study how reward and mood processing is affected across multiple brain areas in depression. We will use the resulting models of the neurobehavioral basis of depression to develop new patient-tailored invasive neurostimulation therapeutical strategies.

PI_NAMEs: SAEZ, IGNACIO  (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Address;Affect;Amygdaloid structure;Anatomy;Anhedonia;Area;Behavior;Behavioral;Biological;Brain;brain machine interface;Brain region;comorbid depression;Complex;cost;Data;Decision Making;Deep Brain Stimulation;Depressed mood;depressed patient;depressive symptoms;Development;disability;Disease;disease model;Dissociation;Effectiveness;Electroencephalography;Electrophysiology (science);Emotional;Epilepsy;Event;feature selection;Foundations;Frequencies;Health Care Costs;Heterogeneity;high dimensionality;Hippocampus;Human;imaging study;improved;individualized medicine;insight;Intractable Epilepsy;Learning;Machine Learning;machine learning method;Major Depressive Disorder;Maps;Mental Depression;Mental disorders;Methods;Modeling;Monitor;Moods;Nature;neural;neural model;neurobehavioral;Neurobiology;neurophysiology;Neurophysiology - biologic function;neuroregulation;neurosurgery;Noise;non-invasive imaging;novel;novel therapeutic intervention;Patient Self-Report;Patients;Personal Satisfaction;Persons;Pharmacology;Psychological reinforcement;Regrets;Reporting;Reproducibility;Resolution;response;reward processing;Rewards;side effect;Signal Transduction;Site;spatiotemporal;Technology;temporal measurement;Therapeutic;therapy design;treatment strategy

PROJECT_TITLE: Invasive decoding and stimulation of altered reward computations in depression


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Pregnant women are 10 times more likely to be infected with the food-borne pathogen Listeria monocytogenes than non-pregnant adults, and fetal death occurs in 20-60% of cases. This proposal aims to understand the mechanisms by which the bacterial virulence factor InlB enhances L. monocytogenes invasion of the placenta and transmission from mother to fetus. The knowledge gained from this proposal may eventually lead to improved strategies for treating L. monocytogenes infections and a better understanding of vertical transmission in other infectious diseases.

PI_NAMEs: EALLONARDO, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: 5' Untranslated Regions;abortion;Abscess;Adult;Affinity;Amino Acids;Bacteria;Behavior;Binding;Blood;Cardiac;cell type;Cell Wall;Cells;Clinical;Communicable Diseases;cytokine;Data;design;Diagnosis;Disease;Elderly;Environment;Exhibits;experience;experimental study;fetal;Fetal Death;fetal infection;fetal loss;Fetal Tissues;Fetus;Flow Cytometry;Fluorescence Microscopy;foodborne;foodborne pathogen;Frequencies;Gastroenteritis;General Population;Genetic;Genetic Variation;Goals;gut colonization;Health;Health Benefit;Heart;HIV Seropositivity;immune activation;Immune response;Immune signaling;Immunity;Immunocompromised Host;Immunohistochemistry;improved;In Situ Hybridization;Individual;Infection;infection risk;Inflammatory;InlB protein;insight;intestinal epithelium;Invaded;Knowledge;knowledgebase;Life Style;Listeria monocytogenes;Listeriosis;Mammalian Cell;Membrane Proteins;model organism;Modeling;Molecular;Morbidity - disease rate;mortality;Mothers;Mus;Nature;Neonatal;novel;Nucleotides;Organ;Organism;Outcome;Outcome Study;pathogen;Pathogenesis;Pathology;Patients;Persons;Phenotype;Placenta;placental infection;posttranscriptional;Predisposition;Pregnancy Complications;Pregnancy loss;pregnant;Pregnant Women;prevent;Production;protein expression;protein function;Public Health;receptor binding;Receptor Signaling;Ribosomes;Severities;Signal Transduction;Surface;tool;Transcript;Translations;transmission process;Tropism;Variant;Vertical Transmission;Virulence Factors

PROJECT_TITLE: Deciphering molecular mechanisms underlying vertical transmission of Listeria monocytogenes


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Disparities in HIV and stimulant use outcomes observed among sexual minority men (i.e., non-heterosexual men) are believed to be driven by minority stress (i.e., stigma-related social stress). We aim to conduct a series of studies, guided by the Biopsychosocial Minority Stress Framework, that test the mechanisms through which minority stress may impact HIV viral load among sexual minority men with HIV who use stimulants. Further, we will examine whether the observed effects of minority stress are greater among racial/ethnic minority participants.

PI_NAMEs: MILLER-PERUSSE, MICHAEL JOSEPH (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Acceleration;Address;Affect;Biological;biopsychosocial;career;Clinical;Cocaine;Communities;Conduct Clinical Trials;Continuity of Patient Care;Crack Cocaine;Data;Discrimination;Disparate;Disparity;efficacious intervention;Epidemic;ethnic minority;ethnic minority population;experience;Fellowship;Funding;Future;gender minority health;gender minority health disparity;Goals;Health;Health behavior;Health Disparities Research;health disparity;Heterosexuals;high risk population;HIV;homonegativity;immune health;Immune system;improved;intersectionality;Intervention;Knowledge;Laboratories;Link;Malignant Neoplasms;Measures;Mediation;Mediator;member;men;men of color;Mental Health;Methamphetamine;minority stress;National Institute of Drug Abuse;non-heterosexual;Not Hispanic or Latino;novel;Opportunistic Infections;Outcome;Outcome Assessment;outcome disparities;Participant;Pathway interactions;Patient Self-Report;peer;Population;Powder dose form;programs;Psychologist;Publishing;racial minority;recruit;Research Methodology;Research Support;Risk;Sampling;San Francisco;secondary analysis;Series;Sexual and Gender Minorities;sexual minority health;sexual minority men;skills;social stigma;social stress;social stressor;stimulant use;stressor;substance use;Testing;theories;Training;transmission process;Viral;Viral Load result;Work

PROJECT_TITLE: Minority Stress, Stimulant Use, and HIV among Sexual Minority Men: A Biopsychosocial Approach


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Digestive Diseases;Genetic Testing;Genetics;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Our research program aims to equip biomarker and medical researchers with statistical tools that can enhance the power and rigor of scientific effort aiming to translate knowledge gained from laboratory studies into medical practice. In this cycle, we will address the challenges in outcome ascertainment from prospective cohort studies and propose methods for deriving and validating dynamic surveillance regimens for disease monitoring with multiple biomarkers. The applicability of the proposed methods will be tested in a wide range of practice settings in cancer biomarker studies and integrating our research into clinical settings will help improve survival outcomes and reduce the burden of diseases.

PI_NAMEs: ZHENG, YINGYE  (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: Address;Algorithms;Area;Biological;Biological Markers;biomarker discovery;biomarker evaluation;biomarker selection;biomarker validation;Biopsy;Breast Cancer survivor;burden of illness;Calibration;cancer biomarkers;cancer recurrence;Clinical;Clinical Management;clinically relevant;Collaborations;Colorectal Cancer;Computer software;Data;design;Development;Disease;Disease Outcome;disease prognosis;Disease Surveillance;Evaluation;flexibility;Goals;Guidelines;high risk;improved;individualized medicine;Indolent;interest;Knowledge;Laboratory Study;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;Medical;Methods;Modeling;Monitor;Nature;novel;novel strategies;Outcome;outcome prediction;patient subsets;Patients;personalized medicine;Population;practice setting;predictive marker;predictive modeling;Procedures;Prognosis;prognostic;Prognostic Marker;programs;prospective;Prospective Studies;Prospective, cohort study;Regimen;Research;Research Personnel;Risk;Risk Marker;risk prediction;risk stratification;Scheme;Screening for cancer;Selection Criteria;Selection for Treatments;Statistical Methods;Statistical Models;surveillance strategy;survival outcome;Testing;tool;tool development;Translating;Uncertainty;user-friendly;Validation;validation studies

PROJECT_TITLE: Statistical Methods for Prospective Evaluation of Biomarkers

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Genetics;Human Genome;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE A large percent of people (10-20%) suffers from loss of libido, likely caused by dysfunction of the neural circuit that controls sexual behaviors. The current project will shed light on the cellular and molecular mechanisms of how mating experience drives a neural plasticity and in turn modulates male mating behaviors. As such then, it may suggest potential avenues for investigating aberrant neural circuit wiring that leads to low libido, and molecular and cellular targets for restoring human libido.

PI_NAMEs: YANG, RENZHI  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;Area;Axon;Behavior;behavior test;Behavioral;behavioral study;Brain;Candidate Disease Gene;candidate identification;cell type;cellular targeting;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Development;Disease;Electrophysiology (science);experience;flexibility;Genes;Genetic;genetic manipulation;Genomic Imprinting;Goals;Health;Human;Hypothalamic structure;Image;imaging approach;improved;in vivo;in vivo imaging;Individual;injury recovery;innovation;insight;Instinct;Knock-out;Knowledge;Learning;Libido;Link;male;mating behavior;Measures;Mediating;Memory;Molecular;Molecular Genetics;Molecular Target;Morphology;multiphoton microscopy;Mus;neural circuit;Neural Pathways;neuromechanism;Neuronal Dysfunction;Neuronal Plasticity;Neurons;neuroregulation;novel;Optics;optogenetics;Partner in relationship;Pathway interactions;Performance;Persons;Play;Population;postsynaptic;presynaptic;Presynaptic Terminals;Reagent;Reproductive Behavior;Research;Role;Sex Behavior;Slice;Social Behavior;Structure of terminal stria nuclei of preoptic region;Synapses;Synaptic plasticity;Synaptic Transmission;Tachykinin;Techniques;Testing;Therapeutic;transcriptome sequencing;two-photon;unpublished works;Work

PROJECT_TITLE: Neuronal and genetic imprints of male mating experience

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F03A-E(20)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOLOGY

ORG_NAME: SAN FRANCISCO STATE UNIVERSITY

PHR: The NIH Bridges to the Doctorate Training Program at SFSU is a joint project between the Hispanic Serving Master’s institution, San Francisco State University (SFSU), and the pre- eminent PhD granting institution, the University of California San Francisco (UCSF). It prepares a diverse population of master’s students at SFSU to enter into top ranked biomedical Ph.D. degree programs such as UCSF, with the skills to successfully complete their Ph.D. degrees, en route to careers in the biomedical research workforce. The partnership between SFSU and UCSF addresses the need to diversify the scientific research community at the Ph.D. level.

PI_NAMEs: BLAKE, NICQUET M.J.;FUSE, MEGUMI M. (contact);RIGGS, BLAKE

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: bridge to the doctorate;programs

PROJECT_TITLE: SFSU/UCSF M.S. Bridges to the Doctorate Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Dental, Oral, and Craniofacial Disease;Osteoporosis;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Periodontal disease is one of the most common diseases afflicting the oral cavity and leads to periodontal destruction as well as tooth loss; while current treatments aim to mitigate symptoms and prevent further disease progression, they do not truly repair the already lost or damaged periodontal tissues. Bone sialoprotein (BSP) is an extracellular matrix protein found in mineralized tissues of the skeleton and dentition, including tissues of the periodontal complex (i.e., cementum and alveolar bone). The proposed studies will elucidate how BSP modulates periodontal development and repair through its functions in key cells for periodontal function: cementoblasts, osteoblasts, and osteoclasts, which will ultimately facilitate the development of reparative therapies for periodontal tissues.

PI_NAMEs: ANDRAS, NATALIE LYNN (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Ablation;Address;Adhesions;Adult;Affect;Age;alveolar bone;Binding;Biology;Bite Force;bone healing;bone metabolism;Bone remodeling;Bone Resorption;bone sialoprotein;Cell-Matrix Junction;Cells;Cementoblast;Cementogenesis;Cephalic;Clinical;Collagen;Complex;Coupled;Coupling;craniofacial;Data;Defect;Dental Cementum;Dentition;Development;Disease;Disease Progression;edentulism;Ensure;Epithelial Cells;Epithelium;Exhibits;experimental study;Extracellular Matrix Proteins;Future;Gene Expression;Genes;Gingiva;Goals;healing;Health;Height;Homeostasis;Hydroxyapatites;Impairment;improved;Infection;Inflammation;insight;Integrin Binding;Interpersonal Relations;Invaded;Knockout Mice;Knowledge;Maps;Microbe;mineralization;Modeling;Molecular;Mus;Neural Crest;novel;Oral;Oral cavity;Osteoblasts;Osteoclasts;Osteoporotic;Ovariectomy;Patients;Periodontal Diseases;Periodontal Ligament;Periodontium;Phenotype;Population;Postmenopausal Osteoporosis;Postmenopause;prevent;Process;Proteins;repaired;Research;Rodent Model;Role;self esteem;Serum;skeletal tissue;Skeleton;Source;Symptoms;Testing;Therapeutic;Tissues;Tooth Extraction;Tooth Loss;Tooth structure;United States;Work

PROJECT_TITLE: The Role of Bone Sialoprotein in Modulating Periodontal Development and Repair

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Dietary Supplements;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Iron and folic acid supplementation may reduce the high risk of stillbirth, preterm delivery, low birthweight and other adverse pregnancy outcomes in resource-limited countries such as Botswana. The goal of the proposed research is to identify and evaluate interventions to provide supplementation to pregnant women that address key barriers to successful supplementation and reach populations that would benefit most from intervention. The results of this work will inform supplementation strategies in Botswana and other resource-limited countries and larger-scale intervention studies to provide supplementation to women in Botswana.

PI_NAMEs: CANIGLIA, ELLEN CHRISTINA (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Address;Adherence;Adult;adverse pregnancy outcome;Affect;African;Anemia;antenatal;antenatal care;Area;Berry;Birth;Botswana;career;career development;Cause of Death;Child;Clinic;Clinical;Communicable Diseases;Communities;compare effectiveness;Computer Simulation;Conceptions;cost effective intervention;Country;Data;Demographic Factors;design;Education;Effectiveness;Environment;Epidemiologic Methods;Evaluation;experience;feasibility testing;First Pregnancy Trimester;Folic Acid;Folic acid fortification;folic acid supplementation;Formulation;Fortification;Geographic Factor;Geographic Locations;Gestational Age;Goals;Guidelines;Health Benefit;Health system;high risk;high risk population;HIV;HIV Seronegativity;HIV Seropositivity;improved;Income;Individual;Infant;Infrastructure;International;Intervention;Intervention Studies;Interview;Iron;iron deficiency;Knowledge;Link;Literature;low and middle-income countries;Low Birth Weight Infant;Malaria;Malnutrition;Maternal and Child Health;maternal weight;Measures;medical schools;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Micronutrients;Modification;Neural Tube Defects;Newborn Infant;Outcome;Pharmaceutical Preparations;Policies;Population;Predisposition;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;prenatal;prevent;programs;Proxy;Qualitative Evaluations;Qualitative Methods;Qualitative Research;Recommendation;Research;research and development;Research Personnel;Research Project Grants;Resource-limited setting;Resources;Risk;Risk Factors;Sampling;Science;Sepsis;side effect;Small for Gestational Age Infant;stillbirth;Structure;Subgroup;Supplementation;supply chain;surveillance data;surveillance study;symposium;therapy development;Time;Training;treatment strategy;Underserved Population;Underweight;United Nations;uptake;Woman;Work;World Health Organization

PROJECT_TITLE: Iron and folic acid supplementation strategies during pregnancy and adverse pregnancy outcomes in Botswana

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Heart Disease;Patient Safety;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Pharmaceuticals play a crucial role in the prevention and treatment of cardiovascular disease and other conditions. Additional research is needed to optimize their effectiveness. This K24 award would serve as a platform for the PI to grow her research program in cardiovascular pharmacoepidemiology patient oriented research, participate in career development activities to advance her methodologic knowledge, and spark opportunities for junior clinical investigators to lead clinically meaningful manuscripts while learning state-of- the-art pharmacoepidemiology methods.

PI_NAMEs: LUTSEY, PAMELA L. (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Acceleration;Address;Adult;Adverse event;adverse outcome;Anticoagulants;Area;Atherosclerosis Risk in Communities;Atrial Fibrillation;Behavioral;burden of illness;Cancer Patient;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;Cardiovascular system;career;career development;Characteristics;Clinical;clinical epidemiology;Clinical Investigator;clinical practice;clinically significant;cohort;comparative effectiveness;Comparative Effectiveness Research;Complex;complex data;Data;Data Sources;diabetes control;Disease Outcome;Drug Interactions;Drug usage;Effectiveness;effectiveness evaluation;effectiveness research;Elderly;Environment;Ethnic Origin;experience;flexibility;Funding;Genes;Glean;graduate student;Guidelines;health literacy;Heart failure;human old age (65+);Hypertension;improved;improved outcome;Individual;interest;Intervention;Kidney Diseases;Knowledge;Lead;Learning;Malignant Neoplasms;Manuscripts;Medicare;medication compliance;Mentors;Mentorship;Methodology;Methods;Mid-Career Clinical Scientist Award (K24);Minnesota;Multi-Ethnic Study of Atherosclerosis;multiple chronic conditions;novel;older adult;Oral;Outcome;Participant;patient oriented;patient oriented research;patient population;Patients;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacologic;Pharmacologic Substance;Pharmacological Treatment;Pharmacotherapy;Phenotype;Physiological;Play;Polypharmacy;Population;Populations at Risk;post-market;Prevalence;prevent;Prevention;Principal Investigator;programs;prospective;Proteomics;Publishing;pulmonary arterial hypertension;Quality of Care;Race;Randomized, Controlled Trials;recruit;Recurrence;Research;Research Activity;Research Methodology;Research Personnel;response;Risk Reduction;Role;rural disparities;Sample Size;Sampling;Scientific Advances and Accomplishments;skill acquisition;Structure;student participation;Supervision;Survivors;Techniques;Testing;Time;Training;training opportunity;Translational Research;treatment strategy;Universities;venous thromboembolism

PROJECT_TITLE: Mentoring and Research in Patient-Oriented Cardiovascular Pharmacoepidemiology

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]