FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Obesity

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Obesity is an area of critical public health concern, as it is associated with significant cardiovascular health risks and the onset of cardiovascular disease; as such, the National Institutes of Health has called for an acceleration of efforts to combat these problems from a multi-level, transdisciplinary perspective. In response to this significant public health priority, this training program, housed within Washington University in St. Louis, a world- class research institution with state-of-the-art resources, has recruited and will continue to recruit highly-qualified pre- and postdoctoral trainees from diverse backgrounds across disciplines and placed them within transdisciplinary mentoring teams with faculty members who are leading researchers in the fields of obesity and cardiovascular disease prevention and treatment. These training experiences are producing a diverse cohort of young scientists with the transdisciplinary research skills necessary to address the complex problems of obesity and cardiovascular disease prevention and treatment across the lifespan.

PI_NAMEs: WILFLEY, DENISE ELLA (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Cardiovascular Diseases;Obesity;post-doctoral training;pre-doctoral;Training;Training Programs

PROJECT_TITLE: WUSTL Transdisciplinary Pre- and Postdoctoral Training Program in Obesity and Cardiovascular Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Neurosciences;Nutrition;Pain Research

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Increasing evidence points to a strong link between prandial habits, such as meal timing and size, to metabolic health—independent of total caloric intake. Although diverse signals are known to regulate meal intake, how mechanical stimulation in the gut is sensed and contributes to the inhibition of feeding is less well understood. Determining the genetic and neural mechanisms that underlie meal size control, and how they contribute to physiology and health, will greatly add to our basic knowledge of the regulation of feeding behavior and influence efforts to develop dietary or pharmacological strategies that target prandial habits.

PI_NAMEs: JA, WILLIAM W (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TITLE: TRP channel regulation of feeding behavior in Drosophila

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Immunotherapy;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE – PROJECT 3 The use of immune checkpoint inhibitors has been a major advancement in the management of Head and Neck Cancer (HNC). However, clinical trials evaluating their efficacy have only shown about a 20% response rate in HNC patients. This suggests that our understanding of how tumor cells and the immune system interface is limited. We have demonstrated that the receptor tyrosine kinases Axl and MerTK on the tumor cells play a role in creating an immunosuppressive tumor microenvironment. Further, we have shown that targeting both receptors simultaneously can turn this immunosuppressive “cold” microenvironment to a “hot” immune microenvironment. We will investigate the molecular underpinnings of how Axl and MerTK cooperate to drive a suppressive environment and translate these findings into the clinic.

PI_NAMEs: WHEELER, DERIC L (contact)

PROJECT_TERMS: Aftercare;anti-PD1 therapy;Automobile Driving;axl receptor tyrosine kinase;Binding;Biological Response Modifiers;Cancer cell line;CD8-Positive T-Lymphocytes;cell killing;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;checkpoint therapy;chemotherapy;Clinic;Clinical;Clinical Trials;conventional therapy;cytokine;Data;Dose;Drug Targeting;Environment;experimental study;Family;FDA approved;Growth;Head and Neck Cancer;head and neck cancer patient;Head and Neck Neoplasms;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunocompetent;Immunodeficient Mouse;Immunological Models;Immunologics;Immunophenotyping;immunoregulation;Immunotherapeutic agent;Immunotherapy;in vivo;Individual;Infiltration;Inflammatory;inhibitor;inhibitor therapy;innovation;insight;Knock-out;Knowledge;Laboratories;Leucocytic infiltrate;Macrophage;Malignant Neoplasms;Measures;Medical Oncologist;Microscopy;Modeling;Molecular;monocyte;mouse model;Mus;Myelogenous;Myeloid-derived suppressor cells;neoplastic cell;Newly Diagnosed;novel;novel drug class;novel therapeutics;Operative Surgical Procedures;Outcome;Pathologist;Patients;Phenotype;Pilot Projects;Play;Population;Pre-Clinical Model;precursor cell;Production;programmed cell death ligand 1;Radiation;Radiation Oncologist;Radiation therapy;receptor;Receptor Protein-Tyrosine Kinases;Receptor Signaling;recruit;Recurrence;Reporting;Resistance;response;Role;safety and feasibility;Scientist;Series;Solid Neoplasm;Survival Rate;T cell infiltration;T-Lymphocyte;targeted agent;Testing;Therapeutic;Translating;translational physician;translational study;Translations;tumor;tumor growth;tumor-immune system interactions;TYRO3 gene;United States;Universities;Wisconsin;Work

PROJECT_TITLE: Project 3: Modulation of the head and neck tumor immune microenvironment by targeting the TAM family of receptors


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Services;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NEW YORK

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative The rates of TBI among older adults in the United States have increased in the last decade, and many more older adults are living with the long-term effects of earlier-life TBI. The proposed project will link three existing cohort studies to Medicare claims data to systematically detail health, function, and clinical care pathways among current older adults. This research fits with the current priority of person-centered NIH/NCMRR to evaluate real-world, outcomes through use of large-scale datasets among individuals with disabilities.

PI_NAMEs: KUMAR, RAJ GOPALAN (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;Admission activity;Age;aging process;Awareness;Biological Models;Caregivers;Caring;Cessation of life;Characteristics;Chronic disability;clinical care;cohort;Cohort Studies;Communities;comorbidity;Complication;cost;Data;data harmonization;data infrastructure;Data Linkages;data registry;data repository;data resource;Databases;Development;Disabled Persons;Elderly;Epidemiology;epidemiology study;evidence base;experience;Foundations;Functional impairment;functional status;Funding;Future;Goals;Grant;Guidelines;Health;Health and Retirement Study;health care service utilization;health care settings;health data;Health Service Area;Health Services Research;Healthcare;Home;Hospitalization;Hospitals;human old age (65+);improved;Individual;Infrastructure;Injury;innovation;Inpatients;Investigation;Knowledge;large scale data;late life;Length of Stay;Life;Link;Literature;Long-Term Effects;Measures;Medicare;Medicare claim;Mentors;Mentorship;Methods;Modeling;multimodal data;Neuroepidemiology;novel;nutrition;older adult;Older Population;Outcome;Outpatients;Participant;Pathway interactions;Patient Outcomes Assessments;Patient Self-Report;Patients;Pattern;person centered;Persons;Population;Population Analysis;population based;Population Growth;population health;Population Programs;Positioning Attribute;premature;Procedures;prognostic;Prospective cohort;Prospective Studies;Public Health;Recommendation;Recording of previous events;Registries;rehabilitation research;Rehabilitation therapy;rehabilitative care;Reporting;Research;Research Infrastructure;Research Personnel;response to injury;Risk;Sampling;Severities;Skilled Nursing Facilities;skills;Statistical Data Interpretation;Statistical Methods;Surveys;Time;Training;Trauma;Traumatic Brain Injury;United States;United States National Institutes of Health;Work;Writing;young adult

PROJECT_TITLE: Validating an Administrative Claims Based Case Definition for Traumatic Brain Injury

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Proprioception – the sense of self-movement and body position – is critical for the effective control of motor behavior: dysfunctions of the proprioceptive system can impair balance, motor coordination, motor learning, and cause muscle paralysis. However, despite its importance, little is known about the initial stages of limb proprioceptive processing in any animal. I will utilize the unique and powerful experimental advantages of the fruit fly, Drosophila melanogaster, to better understand how proprioceptive signals are encoded and modulated by behavioral context, as well as how proprioceptive information is relayed to the brain to integrate with behavioral state and motor planning.

PI_NAMEs: AGRAWAL, SWETA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Affect;Afferent Neurons;Anatomy;Animals;Area;Attenuated;Auditory;Axon;Behavioral;Biophysics;Body part;body position;Brain;Brain region;Calcium;cell type;Compensation;Complex;Computer Models;Computing Methodologies;Cues;Data;Disparate;Drosophila genus;Drosophila melanogaster;Electrophysiology (science);Environmental Wind;equilibration disorder;Evolution;expectation;experimental study;Face;Feedback;Femur;flexibility;fly;Focus Groups;Functional disorder;GABA Receptor;Genetic;Goals;Image;insight;Interneurons;Joints;kinematics;knock-down;Leg;limb movement;Limb structure;Locomotion;Measures;Mechanoreceptors;Mentors;millisecond;Monitor;Motion;Motor;motor behavior;motor control;motor learning;Motor Neurons;Movement;multimodality;Muscle;Nerve;Nervous System;neural;Neurons;Non-linear Models;Organ;Paralysed;patch clamp;Pathway interactions;Phase;Physiology;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Posture;Proprioception;Proprioceptor;Publishing;Research;response;Running;Secure;Sensory;Shapes;Signal Transduction;Site;skills;Sorting;Spinal Cord;Structure;Synapses;System;tenure track;Testing;tibia;two-photon;Universities;Vertebrates;Walking;Washington;way finding

PROJECT_TITLE: Context-dependent neural processing of leg proprioception in Drosophila


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Rare Diseases

PI_NAMEs: YANG, DAVID T (contact)

PROJECT_TERMS: anti-cancer research;Bioinformatics;Biological Specimen database;cancer biomarkers;Clinical;clinically significant;Collaborations;Collection;Communities;Computer Assisted;Consultations;Databases;Dedications;design;Funding;Future;Head and Neck Cancer;Head and neck structure;Immune;Immunohistochemistry;Immunooncology;innovation;Investigation;Mission;Molecular;Neck Cancer;Pathology;Patient Care;patient derived xenograft model;preservation;Process;Reproduction spores;Research Personnel;Resources;service utilization;Services;Source;Tissue Microarray;Translational Research;tumor;Universities;Wisconsin

PROJECT_TITLE: Core 1: Biospecimen/Pathology Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Networking and Information Technology R&D (NITRD);Rare Diseases

PI_NAMEs: YU, MENGGANG  (contact)

PROJECT_TERMS: Achievement;Adult;Applications Grants;Architecture;archive data;Area;Award;Bioinformatics;Biometry;Biostatistics Shared Resource;Cancer cell line;Cancer Center;career;Clinical;clinical database;Clinical Research;Collaborations;Communities;Complex;Computer software;Consultations;cost effective;cost efficient;Data;Data Analyses;data archive;Data Collection;data integrity;data management;data quality/integrity;Data Set;data sharing;data standards;data warehouse;Database Management Systems;Databases;Dedications;Development;electronic data;empowerment;Ensure;Environment;experience;Experimental Designs;experimental study;Extramural Activities;Faculty;Formulation;Grant;Head and Neck Cancer;head and neck cancer patient;human error;Human Resources;Image;Informatics;informatics shared resource;Information Dissemination;Infrastructure;Joints;Laboratories;Laboratory Study;Leadership;Malignant Neoplasms;Manuscripts;Maps;Medical Informatics;Methodology;Methods;Movement;Operative Surgical Procedures;Participant;Pathology;Pharmacotherapy;Procedures;programs;Publications;Pythons;Radiation;Recommendation;Recording of previous events;Research;Research Design;Research Methodology;Research Personnel;research study;Role;Secure;Specialist;Statistical Data Interpretation;success;System;Tissue Microarray;translational cancer research;Translations;Triage;Universities;Validation;Wisconsin;Writing

PROJECT_TITLE: Core 2: Biostatistics and BioInformatics Core


PI_NAMEs: THIBEAULT, SUSAN LYNN (contact)

PROJECT_TERMS: Address;anti-cancer research;Budgets;Cancer Center;Collaborations;collaborative environment;Death Rate;design;Development;Diagnosis;Direct Costs;Disease;Ensure;Evaluation;Financial Support;Fostering;Funding;Goals;Grant;Head and Neck Cancer;head and neck cancer prevention;Head and neck structure;high risk;imaging modality;Incidence;innovation;Institution;Malignant Neoplasms;Mentors;Mission;Monitor;Morbidity - disease rate;mortality;multidisciplinary;novel marker;Peer Review;Pilot Projects;Process;Program Research Project Grants;programs;Research;Research Personnel;Resources;Structure;success;translational goal;Translational Research;tumor progression;Universities;Wisconsin

PROJECT_TITLE: Developmental Research Program


PI_NAMEs: CONNOR, NADINE P (contact)

PROJECT_TERMS: Achievement;anti-cancer research;Applications Grants;Area;Attitude;Award;bench to bedside;career;career development;Clinical;Development;Educational Curriculum;Environment;experience;Extramural Activities;Faculty;Fostering;Funding;Future;Goals;Grant;Head and Neck Cancer;Head and neck structure;innovation;Institution;Knowledge;Leadership;Malignant Neoplasms;Marketing;member;Mentors;Methods;Minority Groups;next generation;Oncology;Physicians;prevent;Process;programs;Progress Reports;recruit;Research;Research Personnel;Resources;Scientist;Secure;skills;Solid;Structure;Time;Training;translational cancer research;Translational Research;translational research program;translational scientist;Underrepresented Minority;United States National Institutes of Health;Universities;Wisconsin

PROJECT_TITLE: Career Enhancement Program


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Pain Research;Rural Health;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative: We will create the Tailored Retention and Engagement for Equitable Treatment of OUD and Pain (TREETOP) clinical research center, an IMPOWR clinical research center at the University of Pittsburgh (Pitt) that develops effective, equitable, and sustainable interventions for chronic pain and OUD that improve engagement in medication for OUD treatment and retention in office-based addiction treatment. TREETOP will prioritize two disproportionately impacted communities for whom equitable implementation of effective interventions can be challenging: rural and Black communities. TREETOP’s success will not only advance the science in this area but will advance the professional development of early- career investigators and help grow our field long-term.

PI_NAMEs: HAMM, MEGAN ;MERLIN, JESSICA S (contact);WINSTANLEY, ERIN L

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: addiction;Address;Appalachian Region;Area;Baltimore;Black race;career;Caring;chronic pain;chronic pain management;chronic pain patient;Clinic;clinical center;Clinical Data;clinical pain;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Network;Collaborations;Communities;community partners;comorbidity;Consultations;Data;Data Collection;Data Coordinating Center;data harmonization;Decision Making;Development;Dose;effective intervention;Effectiveness;Effectiveness of Interventions;Ensure;Environment;Equity;experience;flexibility;Funding;Future;Goals;health equity;health organization;Hospitalization;implementation framework;implementation intervention;implementation science;improved;Infrastructure;innovation;Intervention;Leadership;Lived experience;Maryland;Measurement;Measures;Medical;medical specialties;meetings;member;Mentors;Multi-Institutional Clinical Trial;multidisciplinary;National Institute of Drug Abuse;new technology;operation;Oregon;Outcome;outreach;Pain;Pain Clinics;Pain Measurement;pain self-management;Participant;Patient Outcomes Assessments;Patients;Pennsylvania;Pharmaceutical Preparations;Pilot Projects;Positioning Attribute;primary care patient;Process;Productivity;programs;Protocols documentation;racial bias;Randomized, Controlled Trials;Recommendation;Reproducibility;Research;Research Personnel;Research Project Grants;Rural;Science;Site;social stigma;Suboxone;success;Testing;Translational Research;treatment program;United States National Institutes of Health;Universities;West Virginia


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Hematology;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Clotting complications such as deep vein thrombosis and pulmonary embolism (collectively termed as venous thromboembolism [VTE]) are a major health problem, with over 500,000 annual events in the United States alone. There is lack of knowledge of why some patients develop these complications, especially after traumatic injury, and others do not. Our goal is to evaluate novel laboratory tests and therapeutics that will define risk of VTE and that do increase risk of bleeding.

PI_NAMEs: AUTON, MATTHEW ;PARK, MYUNG SOO (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Acceleration;ADAMTS;Address;Adhesives;aptamer;arm;Artificial Intelligence;Binding;Biological Assay;Biological Markers;Blood;Blood Coagulation Disorders;Blood Coagulation Factor;Blood Platelets;Blood specimen;Blood Vessels;Body mass index;Calibration;Categories;Cessation of life;Characteristics;Chemoprophylaxis;cleavage factor;Clinical;Clinical Data;clinically significant;Coagulation Process;Collaborations;Complex;Complication;Consumption;cost;Data;Deep Vein Thrombosis;Deoxyribonuclease I;Deposition;Development;diagnostic strategy;Discipline;diverse data;Elements;Endothelial Cells;Endothelium;Etiology;Event;experience;extracellular;Factor VIII-Related Antigen;Fibrin;Fibrinogen;Fostering;Foundations;Functional disorder;Future;Generations;Goals;Health;Healthcare Systems;Hemorrhage;Hemostatic function;high risk;Hospitalization;Hyperactivity;improved;improved outcome;Incidence;Individual;injured;Injury;insight;Intervention;Joints;Kinetics;Knowledge;Laboratories;Ligands;Machine Learning;Modeling;Molecular Conformation;Monitor;mouse model;Multiple Trauma;Mus;neutrophil;new therapeutic target;novel;Outcome;Pathogenesis;patient population;Patients;Plasma;Play;predictive marker;prevent;Process;Protein-arginine deiminase;Pulmonary Embolism;Quality of Care;Recommendation;Research Personnel;Risk;Risk Assessment;Risk Factors;RNA;Role;Sampling;Science;Scientific Inquiry;Sensitivity and Specificity;sex;Site;Smoking;statistics;Surgeon;syndecan;Testing;Therapeutic;therapeutic target;Thrombin;Thrombophilia;Thrombosis;Time;tissue injury;Tissue Sample;Trauma;Trauma patient;Traumatic injury;treatment strategy;United States;United States National Institutes of Health;venous thromboembolism;Venous Thrombosis;von Willebrand Factor

PROJECT_TITLE: Venous Thrombosis After Traumatic Injury

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Lung;Patient Safety;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The aims of the proposed research are to identify and test practical, sustainable strategies for implementing a multi-condition pathway intervention for children hospitalized with asthma, pneumonia, or bronchiolitis in community hospitals. The proposed research is relevant to public health because will fill crucial gaps in our understanding of potential ways to rapidly improve evidence-based care and health outcomes for children in community hospitals (which provide care for over 70% of hospitalized children in the US). Thus, the proposed research is relevant to NHLBI's aim of testing interventions for implementing evidence-based practices in community settings and NHLBI's mission of reducing the burdens of lung disease among children.

PI_NAMEs: KAISER, SUNITHA VEMULA (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: Adoption;Adult;Antibiotics;Asthma;Bronchiolitis;Caring;Child;Child Care;Child health care;child services;Childhood;Cluster randomized trial;Community Hospitals;Community Participation;community setting;comparison control;Consolidated Framework for Implementation Research;cost;Data Collection;Dedications;effectiveness/implementation trial;evidence base;evidence based guidelines;Evidence based practice;Face;Feedback;General Hospitals;Guidelines;Health;Healthcare;hospital readmission;Hospitalization;Hospitalized Child;Hospitals;implementation barriers;implementation evaluation;implementation facilitators;implementation strategy;improved;Intensive Care Units;Intervention;intervention effect;intervention refinement;Length of Stay;Lung Diseases;Measures;Medical;Mentors;Methods;Mission;multidisciplinary;multilevel analysis;National Heart, Lung, and Blood Institute;Outcome;Paper;Pathway interactions;Pediatric Hospitals;Pneumonia;poor health outcome;Preparation;primary outcome;Protocols documentation;provider adoption;Public Health;Quality of Care;Randomized;Recovery;recruit;Research;Resources;respiratory;Risk;Site;Specific qualifier value;Surveys;Testing;Time;timeline;Visit;Visual;Waiting Lists

PROJECT_TITLE: The SIP Study: Simultaneously Implementing Pathways for Improving Asthma, Pneumonia, and Bronchiolitis Care for Hospitalized Children


ADMINISTERING_IC: AI

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Sleep Research

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will build a foundational metabolic understanding of tonsils, a common immune organ playing a key role in responding to foreign respiratory pathogen invaders in humans, from children and young adults with sleep disorders. This proposal leverages cutting-edge spatial metabolite, protein, and gene profiling technologies to define a new chemical regulation in controlling a key cell type, B cell, while simultaneously testing clinically relevant differences between anatomically distinct B cell subtypes with unique functions in patients with sleep orders in comparison to controls. Thus, the proposed research is relevant to the NIAID's mission that pertains to obtaining new knowledge on how the immune system responds to flu in patients with sleep disorders through molecular research on a dish.

PI_NAMEs: COSKUN, AHMET F. (contact);SINGH, ANKUR

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 3-Dimensional;Affinity;Anatomy;Antibodies;Antibody Affinity;Antigens;B Cell Proliferation;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Biocompatible Materials;Bioinformatics;Biological Assay;Biomedical Engineering;cell type;Cells;Cellular Metabolic Process;Chemicals;Child;Childhood;clinically relevant;Clonal Expansion;Coculture Techniques;cytokine;Cytokine Gene;Data;Defect;Engineering;Exhibits;Exposure to;fatty acid oxidation;Fatty Acids;flu;Fluorescent in Situ Hybridization;Funding;Gene Expression Profiling;Genes;Goals;high reward;high risk;Human;human tissue;Humoral Immunities;Image;Immune;Immune response;Immune system;Immunity;immunoengineering;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Impairment;Individual;Infection;Influenza;Influenza A Virus, H1N1 Subtype;influenza infection;innovation;insight;interdisciplinary approach;Joints;Knowledge;Life;Lipids;Location;Lymphoid;lymphoid organ;Lymphoid Tissue;Maps;Measurement;Mediating;Memory B-Lymphocyte;Metabolic;metabolic abnormality assessment;Metabolic dysfunction;Metabolic syndrome;Metabolism;metabolomics;Methods;Mission;model building;Modeling;Molecular;Morphology;Mus;Mutate;National Institute of Allergy and Infectious Disease;Nature;Obstructive Sleep Apnea;Organ;Organoids;Otolaryngologist;Pathway interactions;Patients;Physiological;Plasma Cells;Play;Proliferating;Proteins;Proteomics;Public Health;Reaction;Regulation;Research;Research Personnel;Resolution;respiratory pathogen;response;Risk;Role;secondary lymphoid organ;Site;Sleep;Sleep Disorders;small molecule;Spatial Distribution;spatiotemporal;Specialized Center;Structure;Structure of germinal center of lymph node;T-Lymphocyte;Techniques;Technology;Testing;Tissues;Tonsil;tool;transcriptome;young adult

PROJECT_TITLE: Decoding Spatially Resolved Single Cell Metabolic Trajectory of Tonsil Tissues and Organoids


ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Narrative: This SPORE is focused on several important themes in kidney cancer: 1) using the growing understanding of kidney cancer biology to target critical pathways and produce durable clinical benefit for patients with advanced kidney cancer; 2) correlating genomic analyses with clinical outcomes to identify molecular biomarkers for the purposes of monitoring and predicting treatment outcome; 3) understanding the mechanisms by which kidney cancer becomes resistant to standard therapies and developing effective treatment combinations.

PI_NAMEs: KAELIN, WILLIAM G.;MCDERMOTT, DAVID  (contact)

PROGRAM_OFFICER_NAME: SCROGGINS, BRADLEY TODD

PROJECT_TERMS: Address;advanced disease;anti-cancer research;base;Basic Science;Biological;Biometry;Boston;Cancer Biology;Cancer Center;career;career development;Center Core Grants;Clear Cell;Clinical;clinical application;Clinical Data;clinical investigation;Clinical Research;Collaborations;Combined Modality Therapy;Communities;community center;Complex;Computational Biology;Creativeness;Critical Pathways;Dana-Farber Cancer Institute;Development;Device or Instrument Development;drug development;effective therapy;Evaluation;Funding;Future;General Hospitals;Genomics;Goals;Grant;Hospitals;immune checkpoint;Immunocompetent;improved;Incentives;Infrastructure;Institution;interest;Israel;Kidney Neoplasms;Knowledge;Laboratory Scientists;Malignant Neoplasms;Massachusetts;Medical center;medical schools;Mentors;Mission;Molecular;molecular marker;Monitor;mouse model;Mutate;Neurofibromin 2;New Agents;novel;Oncogenic;Outcome;Pathology;Pathway interactions;patient population;Patients;Pediatric Hospitals;Physicians;predicting response;Prediction of Response to Therapy;predictive marker;Program Development;programmed cell death protein 1;programs;Progress Reports;Public Health Schools;Renal Carcinoma;Reporting;Research Personnel;Resistance;resistance mechanism;Scientist;Seasons;Specialized Program of Research Excellence;standard care;Stream;success;Talents;Technology;Testing;Time;Tissues;tool;Toxic effect;Translational Research;translational scientist;Treatment outcome;Woman

PROJECT_TITLE: DF/HCC Kidney Cancer SPORE


NIH_SPENDING_CATS: Cancer;Kidney Disease

PHR: Narrative: The Administrative Core has been vital to the successful function of the SPORE. It has handled the scientific, administrative and fiscal responsibilities of the SPORE, maintained the expanded communication and educational efforts of the Program with newsletters and conferences and fostered additional research collaborations both within and outside DF/HCC. It has carried out an annual review of SPORE Projects and Cores, directed the selection of Career Enhancement Program Awardees and Developmental Research Projects and shepherded a thorough selection process for new Projects to be included within the initial SPORE competitive renewal and this competitive renewal application.

PI_NAMEs: MCDERMOTT, DAVID  (contact)

PROJECT_TERMS: Accounting;Administrator;Advocate;anti-cancer research;Applications Grants;authority;Award;Biological Markers;Cancer Center;Cancer Patient;Cancer Survivor;cancer therapy;career;career development;Caring;Charge;Clinical Cancer Center;Clinical Sciences;Clinical Trials;Collaborations;Communication;Community Outreach;Complement;cost;Databases;Development;Diagnosis;Disease;Education;Educational Activities;Ensure;Evaluation;Event;follow-up;Fostering;Funding;Future;Goals;Grant;Guidelines;improved;Individual;Informed and educated patient;Institution;Intellectual Property;interest;International;Leadership;Licensing;meetings;member;Minority;minority communities;minority investigator;Minority Participation;Minority Recruitment;Monitor;Names;Newsletter;operation;Patient Participation;Process;programs;Progress Reports;Property Rights;Publications;Renal Carcinoma;Reporting;Reproduction spores;Research;Research Personnel;Research Project Grants;Resources;Risk Factors;Scientific Advances and Accomplishments;Secure;Structure;success;symposium;Technology;Texas;tool;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: DF/HCC Kidney Cancer SPORE Administrative Core


NIH_SPENDING_CATS: Cancer;Kidney Disease;Networking and Information Technology R&D (NITRD)

PHR: Narrative: Organizing Biostatistical and Bioinformatic expertise as a shared resource core is a cost-effective approach to ensure that collaboration is readily available to SPORE investigators and an effective strategy to guarantee a high degree of integration among projects with interrelated analytic goals and needs. The primary role of the Biostatistics and Bioinformatics (B&B) Core of this kidney cancer SPORE is to ensure that research conducted in the SPORE benefits from efficient experimental design and data analysis; quantitative methods used in SPORE research are appropriate for the design of the study and for the data, and assumptions required for these methods are evaluated and data collected in the Projects are managed and subjected to rigorous quality control to minimize the possibility of errors and are organized within an overall data model and framework that facilitates inter-project collaboration.

PI_NAMEs: CATALANO, PAUL J (contact)

PROJECT_TERMS: Animals;anti-cancer research;Area;Bioinformatics;Biometry;Cancer Center;career development;Clinical;Clinical Research;Collaborations;Computer software;Computing Methodologies;Consultations;Correlative Study;cost effective;Data;Data Analyses;Data Collection;data framework;data integrity;data management;data modeling;Databases;design;Development;Ensure;epidemiology study;Experimental Designs;Genomics;Goals;high standard;Laboratories;Methods;Outcome;Process;Program Development;programs;quality assurance;Quality Control;Renal Carcinoma;Reporting;Reproduction spores;Research;Research Activity;research and development;Research Design;Research Personnel;Resource Sharing;Role;Translational Research;translational scientist

PROJECT_TITLE: DF/HCC Kidney Cancer SPORE Biostatistics and Bioinformatics Core 1


PHR: Narrative:  The TAPCD Core 2 is essential to the success of all the three SPORE Research Projects as well as all future  Career Enhancement Awards (CEPs) and Development Research Projects (DRPs) via the provision of  clinically annotated and highly characterized human kidney cancer specimens, the performance of  sophisticated molecularly-based pathological assays on human tissue specimens and animal model tissues,  and the development of novel models of kidney cancer.

PI_NAMEs: SIGNORETTI, SABINA  (contact)

PROJECT_TERMS: Animal Model;Antibodies;Award;Bar Codes;biobank;Bioinformatics;Biological Assay;Biological Specimen Banks;Biometry;Biopsy;Blood;Boston;cancer Biomedical Informatics Grid;Cancer Center;career;Cellularity;Clinical;Clinical Data;clinical database;Collection;Computer-Assisted Image Analysis;Confidentiality of Patient Information;Consent;Dana-Farber Cancer Institute;Data;Data Analyses;Data Collection;Data Management Resources;Databases;Development;DNA;Ensure;Equipment and supply inventories;experimental study;Formalin;Freezing;Future;General Hospitals;genomic data;Goals;Hospitals;Human;human tissue;Immunofluorescence Immunologic;Immunohistochemistry;Informatics;Institution;Israel;K-Series Research Career Programs;Kidney Neoplasms;laser capture microdissection;Link;Massachusetts;Medical center;Microdissection;Modeling;Molecular;Molecular Analysis;neoplastic;Nephrectomy;novel;Outcome;Paraffin Embedding;Pathologic;Pathology;Patients;Pediatric Hospitals;Performance;Procedures;Process;Proteins;Quality Control;Renal Carcinoma;Renal Cell Carcinoma;research and development;Research Personnel;Research Project Grants;Resources;RNA;sample collection;Sampling;Secure;Services;Shipping;Slide;Specimen;Stains;Standardization;success;System;Technology;tissue fixing;Tissue Microarray;Tissue Model;Tissue Sample;Tissues;tool;tumor;Urine;Validation;Woman;Work

PROJECT_TITLE: DF/HCC Kidney Cancer SPORE Tissue, Acquisition, Pathology and Clinical Data Core 2


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Diagnosis of non-precision medicine targetable lung cancer represents a bleak future with lower chance of survival and a poor quality of life. For many lung cancer patients, the only treatment options available are traditional multi-agent chemotherapy coupled with surgery and/or radiation. This project will explore the pathogenic roles of glycogen in lung cancer biology and progression and drive the discovery of personalized therapies that can be leveraged for the lung cancer patients that only qualify for conventional chemotherapy.

PI_NAMEs: GENTRY, MATTHEW S.;SUN, RAMON C. (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acceleration;Affinity;anti-cancer research;Apoptosis;Automobile Driving;Binding;Biochemical;Biochemistry;Biological Assay;Biology;Biophysics;Cancer Biology;Cancer Etiology;Cancer Patient;Carbon;Cell Cycle;Cell Line;chemotherapy;Clinical;cohort;Coupled;Data;Development;Diagnosis;Etiology;fatty acid oxidation;Future;Genetic;genetically modified cells;Glucose;glucose metabolism;Glycogen;Goals;Histologic;In Situ;in vivo;Kentucky;Knock-out;Knowledge;knowledge base;KRASG12D;Lipids;Longitudinal Studies;Lung;Lung Adenocarcinoma;Lung Neoplasms;Malignant neoplasm of lung;mass spectrometric imaging;Mediating;Metabolic;Metabolism;metabolomics;Metastatic Neoplasm to Lymph Nodes;meter;Methodology;Methods;Modality;Modeling;Molecular;Monitor;mortality;mouse model;Mus;mutant;Mutate;Mutation;NCI-Designated Cancer Center;Non-Small-Cell Lung Carcinoma;novel;Nucleotides;Oncogenic;Operative Surgical Procedures;Organoids;Pathogenicity;Patients;personalized medicine;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Population;pre-clinical;Precision therapeutics;prevent;Proliferating;Property;Proteins;Qualifying;Quality of life;Radiation;Reporting;Resolution;Role;Sampling;Signal Transduction;Squamous Cell Lung Carcinoma;stable isotope;Staging;STK11 gene;Structure of parenchyma of lung;Technology;Testing;Tissues;TP53 gene;Transgenic Mice;tumor;Tumor Biology;tumor metabolism;Tumor Pathology;tumor progression;tumorigenesis;Universities;Visualization

PROJECT_TITLE: Aberrant Glycogen in Lung Adenocarcinoma Tumorigenesis

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Kidney Disease;Orphan Drug;Rare Diseases

PHR: Narrative Most clear cell renal cells carcinomas, the most common form of kidney cancer, are caused by mutation (alteration) of the VHL gene and resulting activation of a protein called HIF2. Drugs that inhibit HIF2 appear promising, but not all patients respond to them and it is highly unlikely they will be curative when used as single agents. This project seeks to understand how clear cell renal cell carcinomas become resistant to HIF2 inhibitors and to identify other proteins that, like HIF2, are selectively required by kidney cancer cells lacking VHL.

PI_NAMEs: KAELIN, WILLIAM G. (contact)

PROJECT_TERMS: Biological Assay;Biological Markers;BRCA1 gene;cancer cell;cancer therapy;candidate marker;CDK4 gene;Cell Death;Cell Line;Cells;Clear cell renal cell carcinoma;Clinic;Clinical;Clinical Trials;Compensation;CRISPR screen;Dana-Farber Cancer Institute;Data;Dependence;Drosophila genus;druggable target;Event;experience;Funding;Generations;Genes;Genetic;genetic approach;Genome;Growth;Human;Infection;inhibitor;Insecta;interest;Laboratories;Lead;Libraries;Malignant Epithelial Cell;mutant;Mutation;new therapeutic target;Noise;novel therapeutics;paralogous gene;Patients;Pharmaceutical Preparations;pharmacologic;Phase I/II Clinical Trial;Phase I/II Trial;Play;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Pre-Clinical Model;predictive marker;Predisposition;Proteins;RB1 gene;Relapse;Renal Carcinoma;Resistance;resistance mechanism;response;RNA Interference;Role;Sampling;Signal Transduction;standard of care;Synthetic Genes;synthetic lethal interaction;therapeutic target;therapy resistant;Time;Tissue Sample;transcription factor;translational goal;tumor;Tumor Suppressor Genes;Tumor Tissue;Validation;Vegf Inhibitor;VHL gene;VHL Gene Inactivation;whole genome

PROJECT_TITLE: Project 1:Targeting HIF2 and VHL Synthetic Lethal Interactions in Kidney Cancer


ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: OVERALL – NARRATIVE The Cold Spring Harbor Laboratory Cancer Center is dedicated to making foundational discoveries that reveal how tumors initiate and progress, producing novel tools, approaches, and cancer models that are used around the world. With world-renowned scientists and state-of-the-art facilities, the Cancer Center will continue to concentrate on basic cancer research, with increased links to patients so that these findings can be translated into clinical applications that will improve the diagnosis, treatment, and prevention of cancer.

PI_NAMEs: TUVESON, DAVID A (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: anti-cancer research;Award;Basic Cancer Research;Basic Science;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer genetics;cancer genomics;Cancer Model;Cancer Patient;cancer prevention;cancer therapy;Centers of Research Excellence;clinical application;clinical translation;Collaborations;Communication;Communities;Cost efficiency;Dedications;Development;Diagnosis;Ensure;Evaluation;Foundations;Funding;Gene Expression Regulation;Goals;Heterogeneity;Human Biology;Human Genetics;improved;Infrastructure;innovation;International;Journals;Laboratories;Leadership;Link;Malignant Neoplasms;member;Mission;Modeling;Molecular;NCI Center for Cancer Research;neoplastic;novel;Paper;Patients;Peer Review;Prevention;programs;Publications;Publishing;Research;Research Infrastructure;Research Institute;Research Personnel;Resource Sharing;Role;Science;Scientist;Services;Technology;Time;tool;Training and Education;Translating;tumor initiation;tumorigenesis

PROJECT_TITLE: CSHL Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: TULSA

ORG_NAME: OSU CENTER FOR HEALTH SCIENCES

ORG_STATE: OK

PHR: NARRATIVE Adverse Childhood Experiences (ACEs) are a leading public health problem, contributing to poor mental and physical health, substance abuse and other health-harming behaviors, and are often generationally transmitted. In order to reducing the harmful effects of ACEs, research is needed that better explains how childhood adversity affects developing biological systems and how protective experiences can mitigate those effects. The purpose of the Center for Integrative Research on Childhood Adversity (CIRCA) Phase 2 application is to expand on the accomplishments in Phase 1, growing and strengthening a sustainable center that supports researchers with the mentoring, training, and resources to study the effects of ACEs on multiple biological and behavioral systems and identify more effective ways to prevent and treat the effects of ACEs.

PI_NAMEs: CROFF, JULIE MAY (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Address;Adolescent;adverse childhood events;Affect;Anterior;Behavior;behavior measurement;Behavioral;biobehavior;Biological;biological systems;Brain region;career;Cells;Centers of Research Excellence;childhood adversity;Collaborations;Collection;community advisory board;cost;COVID-19 impact;data repository;Daughter;Dendritic Cells;design;Development;Developmental Process;early life adversity;efficacy testing;emotion regulation;Endocrine;epidemiologic data;Equipment;experience;experimental study;Faculty;Functional Magnetic Resonance Imaging;Funding;Future;Gene Expression;Generations;Genes;Genetic;Glucocorticoids;Goals;Grant;Growth;healing;Health;Health Promotion;Health Sciences;Healthcare;Human Development;Hydrocortisone;Immune;Immune system;infancy;Infrastructure;innovation;Institution;intergenerational;Investments;Knowledge;Life Cycle Stages;Link;Mental disorders;Mental Health;Mentors;Metabolic;Methylation;monocyte;Mothers;multidisciplinary;neurobiological mechanism;neurofeedback;North America;NR3C1 gene;Oklahoma;Organizational Affiliation;Outcome;Pathway interactions;Perinatal;Phase;physical conditioning;Pilot Projects;prevent;Prevention;Process;programs;promote resilience;protective factors;Protocols documentation;Public Health;Recording of previous events;Recovery;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;resilience;Resources;Risk;Science;Scientist;stress reactivity;Substance abuse problem;System;Time;Training;transmission process;Trauma;United States National Institutes of Health;Universities;vaccine efficacy


NIH_SPENDING_CATS: Cancer;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: ADMINISTRATION- PROJECT NARRATIVE Not required per PAR-20-043

PROJECT_TERMS: Accounting;anti-cancer research;Area;Award;Budgets;Cancer Center;Cancer Center Support Grant;cancer research center director;Collaborations;Data;Databases;Decision Making;Dedications;Development;Education;Ensure;Expenditure;experience;Faculty Recruitment;faculty support;Feedback;Fostering;Funding;Goals;Health Services Accessibility;Human Resources;information gathering;Information Technology;Institution;Knowledge;Laboratories;Leadership;Malignant Neoplasms;meetings;member;Monitor;multidisciplinary;operation;Peer Review;Pilot Projects;Policies;prevent;Process;programs;Progress Reports;Publications;Reporting;Research;Research Personnel;Resource Sharing;Running;Strategic Planning;Structure;Translational Research;Update

PROJECT_TITLE: Administration


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases

PHR: Narrative: PD-1 blockade-based therapies have transformed the management of advanced renal cell carcinoma (RCC), but too many patients still do not receive durable benefit, and it remains unclear how to best match the right immunotherapy regimen to an individual patient. By leveraging our unique access to informative tumor samples from anti-PD-1 clinical trials and our comprehensive immunopathology and immunogenomics tool-kit for dissection of the tumor-immune microenvironment, we aim to develop biomarkers for durable benefit (to clarify first-line therapy decisions) and determine the key drivers of anti-PD-1 response (and resistance) in RCC. This work has the potential to optimize the application of currently effective anti-PD-1-based therapies for patients with advanced RCC and to provide new and effective immunotherapy approaches for those destined to not benefit optimally from current regimens.

PI_NAMEs: WU, CATHERINE JU-YING (contact)

PROJECT_TERMS: Address;anti-CTLA4;anti-PD-1;Antigen Targeting;antigen-specific T cells;Antigens;Antitumor Response;Area;Biological;Biological Markers;biomarker identification;biomarker performance;cancer cell;CD8-Positive T-Lymphocytes;Cells;Cellular Immunity;checkpoint inhibition;Clear Cell;Clear cell renal cell carcinoma;Clinical;clinical application;Clinical Investigator;Clinical Trials;Clone Cells;Collaborations;combinatorial;Combined Modality Therapy;CTLA4 gene;Dana-Farber Cancer Institute;Development;Dissection;Effectiveness;Goals;Grant;Immune;Immunity;Immunogenomics;Immunologist;immunopathology;Immunotherapy;improved;individual patient;industry partner;insight;ipilimumab;KDR gene;kidney cell;Knowledge;Lead;Link;Malignant Epithelial Cell;Mediating;Modeling;Mutation;neoantigen vaccination;neoplastic cell;new therapeutic target;Nivolumab;novel;Pathologist;patient subsets;Patients;PD-1 blockade;PD-1 pathway;PD-1/PD-L1;PDL1 pathway;pembrolizumab;phase III trial;Population;Positioning Attribute;predictive modeling;programmed cell death protein 1;Progress Reports;prospective;quantum;Regimen;Renal Carcinoma;Renal Cell Carcinoma;Reproduction spores;Research Personnel;Resistance;Resources;response;sample collection;Sampling;Solid Neoplasm;Specificity;Specimen;Subgroup;T cell clonality;T cell infiltration;T-Cell Receptor;T-Lymphocyte;Therapeutic;Tissue Banks;trial comparing;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Project 2:  Optimal Targeting of the PD-1/PD-L1 Pathway in MRCC


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE The androgen receptor (AR) plays a critical role in lethal prostate cancer and despite initial clinical benefit with AR targeted therapy, both intrinsic and more often acquired resistance represents a major challenge. An emerging mechanism of acquired resistance is adaptation to non-canonical AR activity. Thus, in this proposal, we will test the role of identified master regulatory TFs in modulating non-canonical AR activity that aids enzalutamide resistance and determine optimal therapeutic options to overcome resistance using preclinical models.

PI_NAMEs: ADELAIYE-OGALA, REMI  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Abate;abiraterone;addiction;Address;advanced disease;advanced prostate cancer;androgen independent prostate cancer;Androgen Receptor;Animals;antagonist;Architecture;Automobile Driving;Back;Binding;Biological Assay;Biology;Cancer Burden;cancer cell;Cells;ChIP-seq;Chromatin;Clinic;Clinical;Clinical Management;Combined Modality Therapy;Data;Disease;DNA;drug discovery;effective therapy;ELF3 gene;Enhancers;enzalutamide;Exposure to;Gene Expression;Genetic Transcription;Goals;high risk;improved;improved outcome;interest;Knowledge;Malignant neoplasm of prostate;Mediating;men;Modeling;Molecular;multimodality;multiple omics;Neighborhoods;neoplastic cell;novel;optimal treatments;Organoids;Pathway interactions;patient derived xenograft model;patient subsets;Patients;Pattern;pharmacologic;Phase I Clinical Trials;Phase II Clinical Trials;Phenotype;Physicians;Play;Population;pre-clinical;Pre-Clinical Model;preclinical trial;promoter;protein expression;Proteins;Proteomics;RARA gene;receptor expression;recruit;relapse patients;Reporting;Resistance;Resistance development;Resolution;Role;Scientist;Signal Transduction;Systemic Therapy;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Toxicology;transcription factor;transcriptome sequencing;transcriptomics;Translating;treatment strategy;tumor;tumor heterogeneity

PROJECT_TITLE: Therapeutic targeting of master regulators in non-canonical AR driven advanced lethal prostate cancers

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: CHICAGO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The development of brain-controlled prosthetic arms promises to provide independence to users, but current efforts suffer from at least two limitations: first, they are limited in their ability to coordinate arm and hand movements due to the way that decoders are trained, and second, they only harness a small fraction of the activity in motor cortex to infer motor intent. We propose to address these two limitations by leveraging advances in our basic understanding of motor control and by testing next-generation decoders in sophisticated and realistic VR scenarios.

PI_NAMEs: DOWNEY, JOHN E (contact);KAUFMAN, MATTHEW TYLER

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Action Research;Activities of Daily Living;Address;Algorithms;arm;arm function;arm movement;Artificial Arm;Back;Behavior;Behavioral;Biomimetics;Brain;brain computer interface;Clinical Trials;Complex;cooking;Data;design;Development;Digit structure;Distal;Eating;experimental study;falls;Feedback;flexibility;Funding;Generations;Goals;grasp;Hand;Hand functions;Home;Human;Impairment;Implant;improved;Individual;insight;kinematics;Learning;Life;Limb structure;Liquid substance;Location;Mechanics;microstimulation;Modeling;Monkeys;Motion;Motor;motor control;Motor Cortex;Motor output;Movement;Multi-Institutional Clinical Trial;neural;Neurologic;neuron component;Neurons;next generation;novel;Output;Paralysed;Participant;Pattern;Performance;performance tests;Persons;Physics;Population;Positioning Attribute;Procedures;Prosthesis;prototype;Robotics;Role;sensor;Shapes;Signal Transduction;Site;Somatosensory Cortex;Source;Structure;Tactile;Testing;Time;Training;training data;Upper Extremity;User-Computer Interface;virtual;virtual reality;virtual reality environment;virtual reality simulation

PROJECT_TITLE: Improved Brain-Computer Interface Decoding for Activities of Daily Life

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Immunization;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases

PHR: Narrative In this proposal we show that expression of the B7 family member HERV-H LTR-associating 2 (HHLA2) is present in the majority of ccRCC and may serve to suppress T cell function and promote resistance to PD-1 blockade. We have developed antibodies that selectively block the binding of HHLA2 to a newly discovered inhibitory receptor (KIR3DL3) and enhance anti-tumor responses. Our goal is to identify therapeutic antibodies that block the HHLA2 Inhibitory Pathway and test the optimized agent in human ccRCC clinical trials.

PROJECT_TERMS: anti-PD-1/PD-L1;anti-PD1 therapy;anti-tumor immune response;Antibodies;Antitumor Response;B-Lymphocytes;Binding;Biological Markers;Blocking Antibodies;cancer therapy;CD28 gene;Cell Physiology;Cells;Clear cell renal cell carcinoma;Clinical;Clinical Research;Clinical Trials;clinically significant;CTLA4 gene;Dana-Farber Cancer Institute;Data;Development;Endogenous Retroviruses;Family member;Goals;Grant;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immunologist;Immunotherapy;In Vitro;in vivo;in vivo Model;Industry Collaboration;Investigation;Malignant Neoplasms;Modeling;Monoclonal Antibodies;Natural Killer Cells;neoplastic cell;Pathway interactions;Patient Agents;Patients;PD-1 blockade;PD-1 inhibitors;Phase 1/1b Clinical Trial;Phase I Clinical Trials;Population;Pre-Clinical Model;preservation;pressure;Primates;programmed cell death ligand 1;programmed cell death protein 1;Proteins;Reagent;receptor;Regulation;Regulatory Pathway;Renal Carcinoma;Reproduction spores;Research Personnel;Resistance;Resistance development;response;Specimen;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic Agents;Therapeutic antibodies;therapeutic target;Toxic effect;translational goal;tumor microenvironment;tumor progression

PROJECT_TITLE: Project 3:  HHLA2 as a THerapeutic Target in RCC


PHR: Narrative: The Developmental Research Program of the DF/HCC Kidney Cancer Program is intended to attract established investigators to the field of kidney cancer in order to develop new ideas of investigation which may change the field or be developed into full projects in the SPORE

PROJECT_TERMS: Cancer Research Project;Complement;Dana-Farber Cancer Institute;Development;Ensure;Evaluation;Funding;Infrastructure;innovation;Investigation;mindfulness;novel;programs;Renal Carcinoma;Reproduction spores;Research;research and development;Research Personnel;Research Project Grants;success

PROJECT_TITLE: Development Research Project (DRP)


PHR: CEP Narrative: The CEP aims to attract and develop the next generation of translational investigators in kidney cancer.

PROJECT_TERMS: Award;Cancer Center;career;Clinical;Dana-Farber Cancer Institute;Evaluation;Faculty;Funding;Goals;Individual;Infrastructure;Mentors;Mentorship;Monitor;next generation;Process;Program Evaluation;Program Reviews;programs;Renal Carcinoma;Research Personnel;success;translational scientist

PROJECT_TITLE: Career Enhancement Program (CEP)


PHR: CANCER RESEARCH TRAINING AND EDUCATION COORDINATION- PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: TROTMAN, LLOYD C (contact)

PROJECT_TERMS: anti-cancer research;Area;Basic Science;Cancer Center;Cancer Center at Cold Spring Harbor Laboratory;Cancer Center Support Grant;cancer research center director;career;career development;Clinic;clinical practice;Communication;Complement;Data;data acquisition;DNA;Education;education research;Educational workshop;efficacy evaluation;elementary school;Environment;Evaluation;evidence base;Faculty;faculty support;Fostering;Funding;General Population;Goals;graduate student;Grant;Institution;Investments;K-Series Research Career Programs;Leadership;Learning;lectures;Malignant Neoplasms;meetings;member;Mentors;Mentorship;Methods;Minority-Serving Institution;National Research Service Awards;new technology;Outcome;Paper;Patient Care;Phase;Postdoctoral Fellow;programs;Publishing;Reproducibility;Research;Research Personnel;Research Training;Resources;responsible research conduct;Running;Secondary Schools;skills;Students;Surveys;Training;Training and Education;undergraduate student;United States National Institutes of Health;Work

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: CANCER GENETICS AND GENOMICS PROGRAM- PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: VAKOC, CHRISTOPHER  (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Algorithms;Aneuploidy;Antineoplastic Agents;Area;Atlas of Cancer Mortality in the United States;Biological;Biological Models;BRAF gene;cancer cell;Cancer Center;Cancer Center Support Grant;cancer genetics;cancer genome;cancer genomics;Cancer Patient;Cancer Vaccines;Cells;chemotherapy;Clinic;Clinical;clinical application;Clinical Research;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Computer software;computerized tools;computing resources;cost;Data Set;Dependence;design;Detection;detection method;Detection of Minimal Residual Disease;Development;Diagnostic;Disease;Early Diagnosis;Epitopes;Evolution;Funding;Genetic Screening;genetic variant;Genome;genomic data;genomic profiling;Genomics;Grant;Health;high throughput screening;human tissue;improved outcome;inhibitor;innovation;insight;Institution;Intervention;invention;Journals;Laboratories;leukemia;Malignant Neoplasms;Melanoma Cell;member;Methodology;Methods;Mollies;Monitor;new technology;new therapeutic target;novel;Oncologist;Paper;Pathogenesis;patient prognosis;Peer Review;pharmacologic;Philosophy;Printing;Process;Prognosis;programs;Publications;Publishing;rare cancer;recruit;Recurrent tumor;Research;Research Personnel;Resistance;Resolution;salt-inducible kinase;Scientist;single-cell RNA sequencing;software development;Software Tools;Specimen;success;Technology;technology development;Therapeutic;Therapeutic Intervention;tool;Toxic effect;transcriptome;transcriptomic profiling;Tumor Immunity;Validation

PROJECT_TITLE: Cancer Genetics and Genomics Program


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Hematology;Prevention;Rare Diseases;Sickle Cell Disease

ORG_NAME: NEW YORK BLOOD CENTER

PHR: Transfusions remain life-saving treatments for patients with sickle cell disease, but patients may develop life- threatening transfusion reactions, referred to as hyperhemolysis, in which their own red cells as well as the transfused ones are destroyed, and their body cannot produce new red cells. Our studies have identified a key inflammatory protein called interferon that appears to both increase red cell destruction and decrease red cell production in sickle cell disease, leading us to investigate its role as a potential driver of hyperhemolysis and as a target of therapies to prevent and treat this devastating transfusion complication in patients with sickle cell disease.

PI_NAMEs: AN, XIULI  (contact);ZHONG, HUI

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Acceleration;Acute;Address;Adult;Anemia;Antibodies;Autologous;Biological Assay;Biological Markers;Blocking Antibodies;Blood Vessels;CD36 Antigens;CD47 gene;cell age;Cell Culture System;Cell Line;Cells;Cessation of life;CFU-E;Circulation;Complication;crosslink;Data;Defect;Development;effective therapy;EPOR gene;Erythroblasts;Erythrocyte Transfusion;Erythrocytes;Erythroid;Erythroid Cells;Erythrophagocytosis;Erythropoiesis;experience;Fc Receptor;Genes;Growth;Heme;Hemoglobin;Hemoglobinopathies;Hemolysis;Hemolysis Induction;Hemolytic Anemia;Human;Immune;Impairment;In Vitro;in vivo;Inflammatory;inhibitor;Interferon Type I;Interferons;Iron;Iron Chelating Agents;Iron Chelation;Knock-out;Knockout Mice;Life;Ligands;Macrophage;Mediating;Modeling;Molecular;monocyte;mouse model;Mus;new therapeutic target;Pathologic;Pathway interactions;patient population;Patients;Phagocytes;Phagocytosis;Plasma;Predisposition;premature;prevent;Prevention;Probability;Production;Proteins;Reaction;receptor;Recovery;Reticulocytes;risk stratification;Role;Sampling;Severities;Sickle Cell;Sickle Cell Anemia;Signal Transduction;STAT1 gene;STAT2 gene;SYK gene;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Thrombospondin 1;Thrombospondins;Time;Transfusion;Up-Regulation

PROJECT_TITLE: Transfusion-driven hyperhemolysis in sickle cell disease

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Genetics;Hematology;Hodgkin's Disease;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative: HIV positive patients are prone to developing KSHV, and EBV positive B-cell lymphomas with a latency III program, similar to in vitro transformed LCLs, where EBNA3C is an essential oncogene for immortalization. This study examines its functions in reprogramming infected B- cells through regulation of the Rb-CycinD-E2F network by post translational modification. Insights from these studies will provide information about potential targets for therapeutic interventions in treating EBV, and KSHV B-cell lymphomas in HIV Patients.

PI_NAMEs: ROBERTSON, ERLE S. (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acetylation;Acetyltransferase;Acquired Immunodeficiency Syndrome;Affect;AIDS-Related Lymphoma;Automobile Driving;B Cell Proliferation;B lymphocyte immortalization;B-Cell Lymphomas;B-Lymphocytes;Binding;Biochemical;Burkitt Lymphoma;Cell Cycle;Cell Cycle Progression;Cell Cycle Progression Pathway;Cell Cycle Regulation;Cell Reprogramming;Cell Survival;cell transformation;Cells;co-infection;Complex;Cyclin D1;Cyclins;Degradation Pathway;Disease;DNA Damage;E2F transcription factors;Epstein Barr Virus B cell lymphoma;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Escherichia coli;Family;Family member;gammaherpesvirus;Gene Expression;Genes;Genetic Transcription;Genome;Goals;HIV;HIV Seropositivity;Hodgkin Disease;Human;Human Herpesvirus 4;Human Herpesvirus 8;Human Papillomavirus;Immune;Immunocompromised Host;In Vitro;Individual;infected B cell;Infection;insight;Intervention;Knock-out;Knowledge;Lead;Link;lymphoblastoid cell line;Lymphoma;Malignant - descriptor;Malignant Neoplasms;Mammalian Cell;Mediating;Modeling;Modification;Molecular;Molecular Biology;Molecular Genetics;molecular modeling;multicatalytic endopeptidase complex;mutant;Mutate;new therapeutic target;Non-Hodgkin's Lymphoma;novel;novel therapeutic intervention;Nuclear Antigens;Nuclear Protein;Oncogenes;Oncogenic;Oncogenic Viruses;Pathology;Patients;Phenotype;Phosphorylation;Phosphotransferases;Polyomavirus;Post-Translational Protein Processing;post-transplant;programs;Proliferating;Proteins;recombinant virus;Recombinants;recruit;Regulation;response;Retinoblastoma Protein;Role;Satellite Viruses;Site;targeted treatment;Testing;Therapeutic Intervention;transcription factor;Transcription Repressor;transforming virus;Tumor Suppressor Proteins;Ubiquitination;Untranslated RNA;Viral;Viral Genes;Viral Genome;Virus Diseases;Western Blotting

PROJECT_TITLE: Tumor suppressor reprogramming by EBV through post-translational modification

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: GENE REGULATION AND INHERITANCE PROGRAM- PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: SPECTOR, DAVID L (contact)

PROJECT_TERMS: 5' Splice Site;adaptive immune response;Antisense Oligonucleotides;biobank;Biological Assay;biological systems;Biology;cancer cell;Cancer Center at Cold Spring Harbor Laboratory;Cancer Center Support Grant;cancer initiation;cancer therapy;Cell Cycle;Cell Cycle Proteins;Cell Differentiation process;CHRM4 gene;Chromatin;Clinic;Clinical;Collaborations;Communication;Computer Analysis;Dependence;Development;DNA biosynthesis;DNA Replication Factor;DNA-Directed RNA Polymerase;Dysmyelopoietic Syndromes;Epigenetic Process;Erythroid;fundamental research;Funding;Gene Expression;Gene Expression Regulation;gene network;Gene Proteins;Genes;Genetic Transcription;Genome;Glean;Grant;Health;industry partner;insight;Institution;interest;Journals;knock-down;Maintenance;Malignant Neoplasms;Mammary Neoplasms;Mediating;member;MicroRNAs;Modeling;Molecular;mRNA Precursor;Mus;Mutation;Neoplasm Metastasis;new therapeutic target;novel;novel strategies;Oncogenic;Organoids;Paper;Pathogenicity;Pathway interactions;Patients;Pattern;Peer Review;Pharmaceutical Preparations;Post-Transcriptional Regulation;posttranscriptional;pre-clinical;preclinical study;prevent;Printing;Process;programs;protein function;Protein Isoforms;Publications;Publishing;Refractory;Regulation;Research;Research Personnel;RNA;RNA Interference;RNA Splicing;Sampling;single cell technology;small molecule;Splice-Site Mutation;standard of care;stem cell differentiation;targeted treatment;Therapeutic Agents;therapeutic target;transcription factor;Translating;tumor growth;tumor microenvironment;tumor progression;tumorigenesis;Untranslated RNA;Work

PROJECT_TITLE: Gene Regulation and Inheritance Program


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: The proposed research is relevant to public health because alpha-synuclein pathology is linked to various neurological diseases including Parkinson's disease and Lewy body dementia, and understanding the underlying disease mechanisms will allow us to develop a novel intervention therapy. Thus, this research is relevant to the NIH's mission that pertains to supporting the ongoing basic research, foster research that has immediate medical relevance, and encourage translational research that links the discoveries from basic research into therapeutic interventions for treating neurological disorders such as Parkinson's disease and Lewy body dementia.

PI_NAMEs: BURRE, JACQUELINE  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Acceleration;alpha synuclein;Area;Basic Science;Behavior;Behavioral Assay;Binding;Biochemical;Biochemistry;Biological;biophysical techniques;Brain;brain tissue;Cells;Cellular biology;Cessation of life;Cognitive;Complex;Data;Dependence;Development;Disease;Disease Progression;dopaminergic neuron;Dose;Electrostatics;Exhibits;Fostering;Functional disorder;Genes;Genetic Polymorphism;Histologic;Hydrophobic Interactions;Impairment;improved;In Vitro;in vivo;Injections;innovation;insight;interdisciplinary approach;Knockout Mice;Lentivirus Vector;Lewy Bodies;Lewy Body Dementia;Link;Liposomes;Location;loss of function;Mediating;Medical;Membrane;Mission;Molecular;Molecular Chaperones;Motor;mouse model;Mus;mutant;Mutation;Nerve;Nervous System Disorder;Neurologic;neuronal survival;Neurons;neuropathology;neurotoxicity;neurotransmitter release;nigrostriatal degeneration;nonhuman primate;novel;novel therapeutic intervention;Onset of illness;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Physiological;premature;Process;protein purification;Public Health;Published Comment;Publishing;rational design;Rattus;Recombinants;Research;single molecule;SNAP receptor;Substantia nigra structure;Synapses;Synaptic Vesicles;synuclein;synucleinopathy;System;Techniques;Testing;Therapeutic Intervention;tool;Toxic effect;trafficking;Transfection;Translational Research;United States National Institutes of Health;Variant;Vesicle;vesicular release;Work

PROJECT_TITLE: The impact of synaptic vesicle-binding of alpha-synuclein on neuron function and neuropathology

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Precision Medicine

ORG_CITY: HOUSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Immunotherapy (IMT) has emerged as a promising treatment strategy across a broad spectrum of human cancers, with multiple agents, particularly immune check point inhibitors, showing promising results in various types of cancers. Its full potential has yet to be realized, partly due to a lack of biomarkers predicting response to treatment. Current immunotherapeutic approaches are mostly unsuccessful due to limited understanding of the tumor microenvironment, limited clinical utility of current immune markers and inconsistent use of assays or technologies that produce meaningful interpretations in studies. The MD Anderson Cancer Immune Monitoring and Analysis Center (MDA-CIMAC) will provide a centralized and harmonized platform for sample collection, processing and quality assurance and use analytically-validated and standardized assays and highly innovative assays and methodologies to offer state-of-the-art analyses for phenotypic, genomic, and functional characterization of responses of patients enrolled on NCI-sponsored early phase immunotherapy clinical trials leading to the identification of biomarkers that will ultimately improve the therapeutic strategies for cancer patients.

PI_NAMEs: AL-ATRASH, GHEATH ;HAYMAKER, CARA L;WISTUBA, IGNACIO I. (contact)

PROGRAM_OFFICER_NAME: THURIN, MAGDALENA

PROJECT_TERMS: Adverse event;Affect;anti-cancer;Basic Science;Bioinformatics;Biological Assay;Biological Markers;biomarker development;biomarker identification;biomarker signature;Biometry;Blood;Blood specimen;Cancer Center;cancer immunotherapeutics;cancer immunotherapy;Cancer Patient;cancer surgery;cancer type;candidate marker;Categories;Cells;Clinical;Clinical Sciences;clinically relevant;Complex;Computer software;Data;Data Analyses;Data Collection;Data Commons;data integration;data management;data quality;Databases;design;Development;Disease;early phase clinical trial;experimental study;genomic biomarker;genomic data;genomic platform;Genomics;Goals;High-dimensional Modeling;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immune system;Immunologic Markers;Immunologic Monitoring;Immunologics;Immunologist;Immunology;Immunotherapeutic agent;Immunotherapy;immunotherapy clinical trials;immunotherapy trials;improved;Infrastructure;inhibitor;innovation;Integration Host Factors;Knowledge;Lateral;Lead;Link;Liquid substance;Malignant Neoplasms;Medical Oncologist;Methodology;Molecular;Molecular Analysis;Molecular Profiling;multidisciplinary;next generation;novel;Outcome;participant enrollment;Pathologic;Pathologist;Pathology;patient response;Patients;Phase;Phenotype;predictive marker;predictive modeling;Procedures;Process;prospective;Protocols documentation;Publishing;quality assurance;Quality Control;Reporting;Research;Research Personnel;Resistance;Resources;responders and non-responders;response;response biomarker;sample collection;Sampling;Secure;Services;Site;Specimen;standard of care;Standardization;Stem cell transplant;System;Technology;Therapeutic;Tissues;translational potential;treatment optimization;treatment response;treatment strategy;tumor;tumor immunology;tumor microenvironment;Validation;web services

PROJECT_TITLE: MD Anderson Cancer Immune Monitoring and Analysis Center MDA-CIMAC


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project narrative The proposed research will evaluate long-term patient outcomes after peripheral vascular interventions for peripheral arterial disease and assess heterogeneity of treatment effect. These will be supported by implementing and advancing data linkage, natural language processing, and effect modifier assessment methods for vascular research. The proposed research is relevant to NIH's mission to foster fundamental knowledge generation and innovative research strategies that will ultimately help protect and improve health.

PI_NAMEs: MAO, JIALIN  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Adverse event;Affect;Algorithms;Amputation;Area;Award;Balloon Angioplasty;Blood Vessels;career development;Characteristics;Clinical;cohort;Data;Data Collection;Data Linkages;Data Science;Data Set;Data Sources;Decision Making;Detection;Development;Devices;efficacy evaluation;electronic health data;Electronic Health Record;electronic structure;epidemiology study;Evaluation;Event;follow-up;Fostering;Generations;Goals;Grant;Health;Heterogeneity;Hospitals;improved;Informatics;innovation;Institution;interdisciplinary approach;Intervention;Knowledge;Label;language processing;Leadership;Legal patent;Length;Lesion;Limb structure;Link;Longitudinal Studies;Machine Learning;machine learning method;Measures;Medical Device;Mentors;Methods;Mission;multidisciplinary;multiple data sources;Natural Language Processing;Natural Language Processing pipeline;New York City;novel;Observational Study;Operative Surgical Procedures;Outcome;Outcome Assessment;Outcomes Research;patient registry;patient subsets;Patient-Focused Outcomes;Patients;Performance;Peripheral;Peripheral arterial disease;Persons;Predictive Value;Procedures;Quality of life;Radiology Specialty;Randomized, Controlled Trials;Registries;Reporting;Research;Research Activity;Research Personnel;Research Support;responsible research conduct;revascularization;Sampling;Severities;Severity of illness;skills;Specificity;Stents;Symptoms;System;Text;tool;Training;treatment effect;United States National Institutes of Health;unstructured data;Update;Vascular Diseases;Work;Writing

PROJECT_TITLE: Leveraging linked registry and electronic health records to examine long-term patient outcomes after peripheral vascular intervention"

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Cachexia;Cancer;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: CELLULAR COMMUNICATION IN CANCER PROGRAM- PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: VAN AELST, LINDA  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Animal Model;Antigen Presentation;Antigens;Attention;Automobile Driving;biological adaptation to stress;Biological Availability;Biological Models;Blocking Antibodies;breast cancer metastasis;Cachexia;cancer cell;Cancer Center;Cancer Center at Cold Spring Harbor Laboratory;Cancer Center Support Grant;cancer initiation;Cancer Model;Cell Adhesion;Cells;chronic infection;Chronic stress;circadian biology;Clinical Trials;Coculture Techniques;Collaborations;Communication;Cross Presentation;CXCR4 gene;Cytotoxic T-Lymphocytes;Dendritic Cells;Dependence;Development;Diagnostic;diagnostic biomarker;diagnostic strategy;Dietary Factors;Dietary Intervention;Disease Progression;Distant Metastasis;Enzymes;Epigenetic Process;Event;Exclusion;Extracellular Matrix;Fibroblasts;Funding;Genes;Goals;Grant;Hepatic;Heterogeneity;Hormonal;host neoplasm interaction;Human;human cancer mouse model;imaging approach;imaging modality;Immune;Immune system;Immunosuppression;in vivo;in vivo imaging;Incidence;Infection;Infiltration;Inflammation;inhibitor;innovation;insight;Institution;interest;Interleukin-6;Journals;ketogenesis;Laboratories;Longitudinal Studies;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;member;Metabolism;Methods;migration;Modeling;Molecular;mouse model;Mus;Neoplasm Metastasis;neural;neutrophil;novel;novel diagnostics;Oncogenic;Oral;Organoids;oxidation;Paper;Pathway interactions;Patients;Peer Review;Phosphorylation;Preventive;Printing;Process;programs;Proteomics;PTPN1 gene;Publications;Publishing;recruit;Research;Research Personnel;Rest;restraint;Role;Scientific Advances and Accomplishments;Signal Pathway;Signal Transduction;single cell sequencing;sleep pattern;Stress;Synapses;Systemic disease;T-Lymphocyte;Therapeutic;Therapeutic Agents;therapeutic target;Translating;Translations;treatment strategy;tumor;Tumor Antigens;Tumor Escape;tumor growth;tumor initiation;tumor progression;tumor-immune system interactions;tumorigenesis;Validation

PROJECT_TITLE: Cellular Communication in Cancer Program


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE We seek NIH support for a diverse cohort of graduate students, postdocs, and early career scientists to attend the 2023 Annual Colorado Immunology and Microbiology Conference (CIMC). The CIMC will significantly improve scientific knowledge in the areas of Immunology and Microbiology including cancer immunology, diabetes, autoimmunity, respiratory immunology, microbial pathogenesis, host-pathogen interactions, inflammation, and therapeutics. The CIMC will bring together the most talented and productive researchers in the field and facilitate their interactions with the next generation of scientists and clinicians.

PI_NAMEs: DORAN, KELLY S (contact)

PROGRAM_OFFICER_NAME: BARTELS, ADELINA EWURA-ABENA

PROJECT_TERMS: Address;Advocacy;Area;Atmosphere;Autoimmunity;Basic Science;career;Clinical;Clinical Investigator;cohort;Collaborations;Colorado;Communicable Diseases;Communication;Communities;Data;design;Development;Diabetes Mellitus;Diagnosis;Discipline;Disease;Disease Progression;educational atmosphere;Ensure;Environment;equity, diversity, and inclusion;Fostering;Funding;Goals;graduate student;Grant;Health;Human;human disease;Immune;Immunity;Immunology;improved;Infection;Inflammation;interdisciplinary approach;Knowledge;meetings;member;microbial;Microbiology;Mission;next generation;Participant;pathogen;Pathogenesis;Postdoctoral Fellow;posters;Productivity;programs;Research;Research Personnel;respiratory;Science;Scientist;Students;success;supportive environment;symposium;Talents;Therapeutic;therapeutic development;Time;tumor immunology;Underrepresented Populations;United States National Institutes of Health;Woman;Work


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Ovarian Cancer;Pancreatic Cancer;Rare Diseases;Women's Health Research

ORG_DEPT: MISCELLANEOUS

PHR: KRAS drives transformation and growth of human cancers from several sites, including pancreatic ductal adenocarcinoma (PDAC) and low-grade serous ovarian cancer (LGSOC), but therapy targeting KRAS remains a work in progress. Upon completion of this grant, we will better understand the role for DIRAS3, a tumor suppressor, in targeting KRAS, inducing autophagy and potentiating the pro-apoptotic activity of autophagy inhibitors in PDAC and LGSOC, opening a new approach to treating KRAS mutant cancers by inhibiting KRAS dimerization/nanoclustering, increasing autophagy and enhancing sensitivity to autophagy inhibitors.

PI_NAMEs: BAST, ROBERT C (contact);LU, ZHEN

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Accounting;Affinity;Amino Acids;Apoptosis;Apoptotic;Autophagocytosis;Binding;Biological;Biological Process;BRAF gene;C-terminal;cancer cell;Cancer Cell Growth;Cancer cell line;cell growth;Cell membrane;cell motility;Cell Proliferation;Cell Respiration;cell transformation;Cells;cellular engineering;Consumption;Cytoplasm;Development;dimer;Dimerization;Disease;Eating;Epithelium;Exhibits;Family member;Fatty Acids;FRAP1 gene;Genetically Engineered Mouse;Goals;Grant;Growth;GTP Binding;Guanosine Triphosphate Phosphohydrolases;Heterodimerization;Homodimerization;Human;Incidence;inhibition of autophagy;Inhibition of Cancer Cell Growth;Inhibition of Cell Proliferation;inhibitor;KRAS oncogenesis;KRAS2 gene;KRASG12D;Laboratories;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Membrane;Metabolic;migration;monomer;Motility;mutant;Mutation;myristoylation;N-terminal;nanocluster;Neoplasm Metastasis;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Nuclear;Nutrient;Oncogenic;Organelles;Ovarian Carcinoma;Ovarian Serous Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Peptides;Physiological;prenylation;Prevalence;Prognosis;Proteins;rare cancer;RAS driven cancer;RAS inhibition;Ras Inhibitor;Recurrent disease;response;Role;Serous;Signal Induction;Signal Pathway;Signal Transduction;Site;stapled peptide;STK11 gene;Surface;targeted treatment;Testing;Therapeutic;treatment strategy;tumor;Tumor Suppressor Proteins;Xenograft procedure

PROJECT_TITLE: DIRAS3 disrupts K-RAS clustering and signaling, enhancing autophagy and response to autophagy inhibition


PHR: DEVELOPMENTAL FUNDS- PROJECT NARRATIVE Not required per PAR-20-043

PROJECT_TERMS: anti-cancer research;Biological;Biology;Cancer Center;Cancer Center Support Grant;cancer prevention;cancer research center director;Chemistry;Collaborations;Creativeness;Data;Development;Diagnosis;Faculty;Funding;Goals;Grant;Immunologist;innovation;Institution;Interdisciplinary Study;Investments;Laboratories;Leadership;Link;Malignant Neoplasms;Paper;Peer Review;Philanthropic Fund;Physiology;Pilot Projects;pre-clinical;Preparation;Printing;Publications;Publishing;recruit;Research;Research Personnel;Resource Sharing;Science;Source;student mentoring;Technology;technology development

PROJECT_TITLE: Developmental Funds


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Health Services;Rehabilitation

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative While older adults prefer to remain in their own homes as they age (i.e., “age in place”), impairments in physical function may limit their ability to do so. Meanwhile, those who undergo residential relocation and those who live in less supportive neighborhood environments experience negative health outcomes including greater healthcare utilization, mortality, and falls with injury. Establishing: 1) whether older adults with cancer are vulnerable to residential relocation in response to impairments in mobility-related physical function and, 2) how such relocation influences cancer-related health outcomes will inform development of patient-, provider-, and system-level strategies to assess and mitigate impairments in physical function and promote aging in place for this growing population. 1

PI_NAMEs: JENSEN-BATTAGLIA, MARIELLE  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Achievement;Activities of Daily Living;Address;Affect;Age;Aging;aging in place;aging related;Area;Award;beneficiary;cancer care;cancer diagnosis;Cancer Patient;cancer type;Caring;Characteristics;Communities;Complex;Critical Illness;Data;Data Set;Dementia;design;Development;Disease;Distress;Environment;Equation;experience;falls;follow-up;Future;Goals;Health;Health Benefit;health care service utilization;Healthcare;Home;Home environment;human old age (65+);Impairment;improved;Individual;Injury;Knowledge;Lead;Link;Location;Malignant Neoplasms;Measures;Medicare;Medicare claim;Mentors;Mobility decline;Modeling;mortality;Myocardial Infarction;Neighborhoods;Newly Diagnosed;novel;Nursing Homes;older adult;Oncology;Outcome;Patients;Pattern;Persons;Phase;Physical environment;Physical Function;Population;Postdoctoral Fellow;pre-doctoral;pro-aging;prospective;Provider;Quality of life;Research;Research Personnel;Research Project Grants;Resources;response;Risk;Role;Sample Size;Sampling;skills;social;standard of care;Structure;System;Time;Training;Transportation;trend;United States;Vulnerable Populations;walkability;Walking;Work

PROJECT_TITLE: Aging in place for older adults with cancer: The role of physical function and home environment


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: RESTON

ORG_NAME: SOCIETY OF TOXICOLOGY

PHR: PAR-19-306 US FDA Scientific Conference Grant Program (R13/U13) Project Narrative: The SOT Annual Meeting provides the most complete and in-depth coverage of toxicology. The SOT Scientific Program Committee is charged with creating a thought provoking and dynamic program that captures all the latest scientific advances that have occurred during the past 12 months. The committee reviews more than 2,000 abstracts to develop a final program that is novel, multi- dimensional, and comprehensive in scope.

PI_NAMEs: ASCHNER, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: GROVES, ASHLEY

PROJECT_TITLE: SOT Annual Meetings


NIH_SPENDING_CATS: Biotechnology;Cancer;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: SHARED RESOURCE MANAGEMENT- PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: TONKS, NICHOLAS K (contact)

PROJECT_TERMS: Back;Bioinformatics Shared Resource;Budgets;Businesses;Cancer Center;Cancer Center at Cold Spring Harbor Laboratory;Cancer Center Support Grant;cancer research center director;Cellular biology;Charge;Collaborations;Communication;conflict resolution;Core Facility;cost effective;Development;DNA sequencing;Education;Ensure;Equipment;Evaluation;Feedback;Funding;Gene Targeting;Genomics;Goals;innovation;Institution;Laboratories;Leadership;member;Mission;Monitor;new technology;next generation;novel sequencing technology;operation;Organoids;Policies;Printing;Publications;Recommendation;Research;Research Support;Resource Sharing;Resources;Services;Training;Work

PROJECT_TITLE: Shared Resource Management


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE  Adolescence is a critical period for emergence of a range of psychiatric syndromes, as well as for maturation of the cerebral cortex. Investigators have long presumed these events to be linked, potentially in ways that can predict specific clinical outcomes, but until now we have lacked data from sufficiently large, prospective studies to establish definitive or tractable patterns. Leveraging data from the ongoing Adolescent Brain Cognitive Development Study (n=11,875), we will map emergent psychopathology across a range of symptoms to specific patterns of cortical development from age 9 to 16, and anchor these relationships to mediating genomic and environmental risk factors.

PI_NAMEs: ROFFMAN, JOSHUA LAWRENCE (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;adolescent mental health;Adult;Age;age acceleration;Age of Onset;age related;artificial intelligence method;Attention deficit hyperactivity disorder;autism spectrum disorder;Biological;Biology;Brain;Cerebral cortex;Child;Child Behavior Checklist;Clinical;cognitive development;Conflict (Psychology);critical period;Data;Development;Dimensions;Disease;Early Diagnosis;Early Intervention;effective intervention;emerging adult;Enrollment;Environmental Risk Factor;Epidemiology;Etiology;Event;experience;Family;Family dynamics;follow-up;Foundations;genomic data;Genomics;Heritability;Image;indexing;Individual;Intercept;Intervention;Knowledge;Life;Link;longitudinal design;Machine Learning;machine learning method;Magnetic Resonance Imaging;Maps;Measures;Mediating;Mediation;Mental Depression;Mental disorders;Mood Disorders;MRI Scans;neighborhood safety;neuroimaging;novel;nutrition;Onset of illness;Outcome;Participant;Pattern;polygenic risk score;postnatal;precision medicine;Predictive Factor;prenatal;Prevention;preventive intervention;Process;Prospective Studies;psychiatric genomics;Psychopathology;psychosis risk;Reproducibility;Research;Research Personnel;Resources;Risk;Risk Factors;Sampling;Schizophrenia;Scoring Method;Site;Socioeconomic Status;spatiotemporal;Specificity;standardize measure;stressor;Symptoms;Syndrome;Testing;theories;Thick;Thinness;Time;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Alignment of cortical development trajectories with emergent dimensional psychopathology and related risk factors among early adolescents in the ABCD Study

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Cancer;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: LEADERSHIP, PLANNING AND EVALUATION- PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: TUVESON, DAVID A (contact)

PROJECT_TERMS: Address;anti-cancer research;Appointment;Area;Basic Cancer Research;Cancer Center;Cancer Center Support Grant;cancer research center director;Communication;design;Development;Education;Ensure;Evaluation;flexibility;Funding;Future;Gene Expression Regulation;Goals;Grant;Health;Human Biology;improved;innovation;Laboratories;Leadership;Malignant Neoplasms;member;Methods;NCI Center for Cancer Research;operation;Positioning Attribute;pre-clinical;programs;Recording of previous events;recruit;Research;Research Personnel;Resource Sharing;Services;Strategic vision;Technology;Training;Translational Research;Vision;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Aging affects global health and contributes to the development of many diseases including metabolic disease and cardiovascular disease. Histone deacetylase 9 (HDAC9) is a regulator of metabolic disease in obesity and here we show novel evidence of a role of HDAC9 in aging. The studies proposed in this application will examine the role of HDAC9 as a mediator of adipose tissue mitochondrial dysfunction and senescence in adipose tissue aging.

PI_NAMEs: GOO, BRANDEE  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: 1 year old;Acceleration;Adipocytes;adiponectin;adipose derived stem cell;Adipose tissue;Affect;Age;age-related disease;aged;Aging;aging related disease;Area;beta-Galactosidase;Biology;Blood Vessels;Body Composition;Cardiovascular Diseases;career;CCL2 gene;Cell Aging;Cell Culture Techniques;collagenase;confocal imaging;Confocal Microscopy;Data;detection assay;Development;diacetyldichlorofluorescein;Diet;Digestion;Disease;Down-Regulation;Energy Metabolism;Epigenetic Process;Female;Fluorescence;Fostering;Gene Deletion;Genes;Genus Hippocampus;global health;glucose tolerance;hallmarks of aging;Harvest;HDAC9 gene;Health;High Fat Diet;Histone Deacetylase;Human;Image;Immunofluorescence Immunologic;Immunohistochemistry;Impairment;improved;In Vitro;Inflammation;insight;Insulin Resistance;Knock-out;Knockout Mice;Knowledge;Laboratories;Link;LoxP-flanked allele;male;Measurement;Measures;Mediator;medical schools;Mentorship;Metabolic;Metabolic Diseases;Metabolic dysfunction;microscopic imaging;Mitochondria;mitochondrial dysfunction;Monitor;mouse model;Mus;novel;Obesity;old mice;overexpression;Oxidative Stress;Physicians;Play;post-doctoral training;pre-doctoral;Predisposition;prevent;Primary Cell Cultures;pro-aging;protein expression;Proteins;Quantitative Reverse Transcriptase PCR;Reactive Oxygen Species;Recording of previous events;Repression;Research;Role;Scientist;senescence;senescent cell;Stains;Sterility;stress reduction;systemic inflammatory response;Technical Expertise;Testing;Therapeutic;Tissue imaging;Tissue Stains;Tissues;Training;Transgenic Mice;Transgenic Organisms;Transmission Electron Microscopy;Ultraviolet Rays;Universities;UV induced;Western Blotting

PROJECT_TITLE: Role of Histone Deacetylase 9 (HDAC9) in adipose tissue aging: mitochondrial function, oxidative stress and senescence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Activity;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Heart failure is one of the leading causes of death in the United States, but it is currently difficult to predict who will develop heart failure. In this study, we will apply machine learning and signal processing techniques to multiple types of data (electronic health records, electrocardiography, and heart rate variability) to predict heart failure onset, and we will use wearable devices to improve the predictions and expand their impact to a wider population. We expect the resulting tools will help prevent delayed diagnosis of heart failure, leading to improved medical outcomes, enhanced patient experience, and reduction in healthcare costs.

PI_NAMEs: ANSARI, SARDAR  (contact)

PROJECT_TERMS: Accelerometer;actigraphy;Affect;Age;American;analytical tool;Arrhythmia;autoencoder;Autonomic nervous system;Award;Behavior Therapy;Cardiac;Cardiovascular Physiology;Cardiovascular system;career;career development;Cause of Death;Clinical;clinical care;clinical decision support;computer scientist;Computing Methodologies;cost;Data;Data Analyses;data modalities;deep learning;Detection;Development;Diagnosis;Diagnostic;Early Diagnosis;Early identification;Early treatment;Educational workshop;Electrocardiogram;Electronic Health Record;Ensure;Excision;experience;Exposure to;Functional disorder;Future;Grant;Health Care Costs;Healthcare Systems;Heart failure;heart rate variability;hemodynamics;Hemorrhagic Shock;high risk;Home environment;Hypotension;improved;improved outcome;Incidence;indexing;Individual;information gathering;Intensive Care Units;Intervention;K-Series Research Career Programs;Lead;Machine Learning;Measures;Medical;Medical History;Medicine;meetings;Mentorship;Methods;Michigan;Modeling;Monitor;Morphologic artifacts;Morphology;mortality;Motion;multimodal data;multimodality;multiple data types;Noise;novel;Onset of illness;Outcome;Outcome Study;patient population;Patient-Focused Outcomes;Patients;Photoplethysmography;Physical activity;Physiology;Pilot Projects;Population;prevent;Price;Procedures;prospective;Prospective cohort;Research;Research Personnel;response;responsible research conduct;Rest;Retrospective cohort;Risk;Sampling;Severities;signal processing;Signal Transduction;smart watch;string theory;support tools;Symptoms;Techniques;Testing;Therapeutic Intervention;tool;Training;Translational Research;Treatment outcome;United States;United States National Institutes of Health;Universities;usability;wearable data;wearable device;Writing

PROJECT_TITLE: Prediction of Heart Failure Onset using Multimodal Data Analysis, Deep Learning and Commercial Wearables


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Lung;Prevention

PHR: Narrative: In this project we will determine the relationship between the genetic and functional diversity of human immunity genes and natural killer (NK) cell driven responses in life-threatening SARS-CoV-2 infection. The exceptional diversity of NK cell functions, driven by HLA and KIR gene variation, arose due to similar threats posed during human history by multiple viral and other pathogens. We will perform a large scale, high resolution, study of this immunogenetic diversity and a functional assessment of the role of NK cells in the development of COVID-19. Our results will help understand why some people or racial/ethnic groups are more likely to develop severe disease upon SARS-CoV-2 infection than others, and lead to therapies that prevent severe COVID-19.

PI_NAMEs: NORMAN, PAUL JOHN (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: 2019-nCoV;A549;adaptive immune response;adaptive immunity;Address;Affect;Age;Algorithms;Alleles;Antibodies;antibody-dependent cell cytotoxicity;Binding;biobank;Biological Assay;Brazil;cell killing;Cell Physiology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Country;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 treatment;cytokine;cytotoxicity;Data;data imputation;Data Set;Detection;Development;Diagnosis;Disease;Effector Cell;Ensure;Epidemic;Epidemiology;Epithelium;Epitopes;Ethnic Origin;Ethnic Population;experimental study;Flow Cytometry;Genes;Genetic;genetic analysis;Genetic Polymorphism;Genetic Variation;Genomics;Genotype;Geography;Goals;Herpesviridae;Histocompatibility Antigens Class I;HIV-1;HLA Antigens;Hospitalization;Human;humanized monoclonal antibodies;Immune Evasion;Immune response;Immunity;Immunogenetics;Immunoglobulins;imprint;Individual;Infection;Infection Control;Influenza;Innate Immune Response;Invaded;Italy;Killer Cells;Laboratories;Left;Ligands;Lung;Measures;Mediating;Methods;multi-ethnic;Natural Immunity;Natural Killer Cells;Nature;Outcome;pandemic disease;pathogen;Patients;Peptides;personalized medicine;Persons;Phenotype;Population;Population Group;post SARS-CoV-2 infection;Predisposition;prevent;Prevention;Preventive measure;Proteins;Race;racial population;receptor;Receptor Gene;Recording of previous events;recruit;reduce symptoms;Research Personnel;Resistance;Resolution;response;Risk;Risk Factors;Role;Sampling;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Severe Acute Respiratory Syndrome;severe COVID-19;Severity of illness;Spain;Specificity;Structure of parenchyma of lung;Surface;Sweden;Symptoms;Target Populations;Testing;Therapeutic;therapeutic target;Time;Tissues;Vaccine Design;vaccine evaluation;Variant;Viral;Virus;Virus Diseases

PROJECT_TITLE: Natural Killer cells and the Immunogenetics of COVID-19

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]