NIH_SPENDING_CATS: Hematology;Prevention;Wound Healing and Care

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Transplants, free flaps, and replantation procedures each require multiple microvascular connections in order to enable integration and vascularization of transplanted tissue. Thombosis at the anastomosis site is the most feared post-operative complication, and is a primary cause of re-operations, extended inpatient stay, potentially- devastating functional and cosmetic morbidity, and increased healthcare costs. Here, we describe a novel nanofiber-based suture platform that can provide immediate and durable release of anti-thrombotic agents directly to the surgical site to prevent thrombosis without modifying the clinical workflow.

PI_NAMEs: PARIKH, KUNAL SAILESH (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: abdominal aorta;Affect;Anastomosis - action;Animal Model;Animals;Anti-Bacterial Agents;Anti-Inflammatory Agents;Anticoagulant therapy;Anticoagulants;Aspirin;Blood Cell Count;Blood flow;Blood Platelets;Blood Vessels;Body part;Body Weight;Calcineurin inhibitor;care burden;Clinical;clinically relevant;clopidogrel;Complication;controlled release;Cosmetics;cytokine;Data;Devices;Diameter;dosage;Drug Delivery Systems;drug efficacy;Drug Kinetics;efficacy evaluation;Endothelium;Ensure;Failure;Family suidae;Fibrinolytic Agents;fondaparinux;Formulation;Fright;healing;Health Care Costs;Hospitals;Hour;Hyperplasia;improved;improved outcome;In Vitro;Infection;Inflammation;Inflammatory;Injury;Inpatients;Legal patent;Lipids;Literature;liver function;local drug delivery;Maintenance;Malignant Neoplasms;manufacture;Metabolic;Methods;Microsurgery;Modeling;Monitor;Morbidity - disease rate;Morphology;nanofiber;nanopolymer;novel;Operative Surgical Procedures;Patients;Pharmaceutical Preparations;Postoperative Complications;Postoperative Period;prevent;Prevention;Procedures;Production;Rattus;Recommendation;repaired;Repeat Surgery;Reporting;Reproducibility;Risk;risk mitigation;safety testing;Secure;side effect;Sirolimus;Site;Skin;small molecule;Sodium;Specific qualifier value;Spleen;success;surface coating;Surgeon;Surgical Instruments;Surgical Replantation;Surgical sutures;Tacrolimus;Technology;Tensile Strength;Testing;Therapeutic;Thick;Thrombophilia;Thrombosis;thrombotic;Time;tissue repair;Tissue Transplantation;Tissues;Toxic effect;Training Programs;Transplantation;Trauma;Triclosan;Vascular Patency;Vascularization;wound

PROJECT_TITLE: Ultra-thin, high strength, drug-eluting sutures for prevention of thrombosis in microvascular surgery

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MORGRIDGE INSTITUTE FOR RESEARCH, INC.

ORG_STATE: WI

PHR: PROJECT NARRATIVE Chimeric antigen receptor (CAR) T cell therapies are FDA-approved adoptive T cell therapies that have been genetically engineered to recognize and kill cancer cells and have improved complete remission rates compared to existing treatments with potential of long term cure. However, effective CAR T cell therapy is highly variable across patients. The label-free single-cell metabolic imaging technologies developed in this proposal could streamline processes and interventions for consistently potent T cell therapy and increase our knowledge of CAR T cell metabolism in vitro and in vivo.

PI_NAMEs: CAPITINI, CHRISTIAN ;SAHA, KRISHANU ;SKALA, MELISSA CAROLINE (contact)

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: alternative treatment;Antitumor Response;Autologous;B-Cell Lymphomas;Benchmarking;Biological Assay;Biological Markers;cancer cell;Cancer Patient;cancer therapy;CAR T cell therapy;CD19 gene;Cell Physiology;Cells;cellular imaging;Cellular Metabolic Process;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;Combined Modality Therapy;cytokine;Cytolysis;Dasatinib;Data;Disease remission;exhaust;exhaustion;FDA approved;fitness;Flow Cytometry;fluorescence imaging;Frequencies;Genetic Engineering;Goals;Human;Hypoxia;Image;Imaging technology;Immunofluorescence Immunologic;improved;In Vitro;in vivo;Infiltration;Infusion procedures;Intervention;Knowledge;Label;Malignant Neoplasms;manufacture;Measurement;Measures;Memory;Metabolic;metabolic imaging;Methods;Modeling;Monitor;mouse model;neoplastic cell;Neuroblastoma;Optics;patient screening;Patient Selection;Patients;Phenotype;predictive modeling;Process;process optimization;Production;Resolution;Resources;response;response biomarker;Sampling;single cell technology;Solid Neoplasm;Source;Specificity;Spleen;stem cells;T cell response;T cell therapy;T memory cell;T-Lymphocyte;Technology;Technology Assessment;Testing;therapy development;Time;tumor;Xenograft procedure

PROJECT_TITLE: Label-free imaging of CAR T cell metabolism


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative While bacterial pathogens manipulate immune responses to cause deadly infections, it is appreciated that nonpathogenic commensals can also mediate these effects. Our studies focus on understanding how a protein domain conserved in numerous pathogens and commensals regulates inflammatory responses. This work could identify new targets or strategies to for development of anti-inflammatory or anti-bacterial therapies.

PI_NAMEs: LENZ, LAUREL L (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Activated Natural Killer Cell;Amino Acids;Animals;Anti-Bacterial Agents;Anti-Inflammatory Agents;Antigens;Antimicrobial Effect;Arthritis;Atherosclerosis;Attenuated;Automobile Driving;Bacteria;Bacterial Infections;Bacterial Proteins;Binding;Bone Marrow;Cells;Chronic;Chronic Obstructive Pulmonary Disease;Cross Presentation;crosslink;cytokine;Data;Dendritic Cells;Development;Endocytosis;Endosomes;Equilibrium;Health;human disease;ICAM1 gene;Immune response;Infection;Inflammation;Inflammatory;Inflammatory Response;Interferon Type II;Interleukin-10;Invaded;Lipids;Listeria monocytogenes;Lung;Lymphocyte;Malignant Neoplasms;Mediating;Membrane Proteins;Microbe;microbial;Mitochondria;Mitochondrial Proteins;Myeloid Cells;Natural Killer Cells;NK Cell Activation;Organism;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Phenotype;Play;polypeptide;Polysaccharides;Predisposition;Production;Proteins;Proteomics;Publishing;Reaction;receptor;Recombinants;release factor;Resolution;response;Role;Route;Shapes;Streptococcus pneumoniae;Surface;Tertiary Protein Structure;Testing;Tissues;tumor;Virulence;Work

PROJECT_TITLE: Dendritic cell targeting by bacterial LysM proteins to suppress inflammation

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative This research will provide insights into how processes at multiple levels of neural organization contribute to regulation of behavior. Using novel technology that may have broad applications to other nervous systems, we will examine how a combinatoric code of key interneurons generates a range of motor behaviors in response to changing challenges; how arousal and satiation are implemented throughout a complex nervous system, and how a distributed learning system modifies behavior to respond to changes in the environment.

PI_NAMEs: BYRNE, JOHN H (contact);CHESTEK, CYNTHIA ANNE;CHIEL, HILLEL J;CROPPER, ELIZABETH C;SUSSWEIN, AVY ;THOMAS, PETER JOHN

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Adaptive Behaviors;Affect;Anatomy;Animals;Aplysia;Arousal;Behavior;Behavior Control;behavior prediction;Behavioral;Biological Models;biomechanical model;Brain;carbon fiber;Cerebrum;Choices and Control;Code;combinatorial;Combinatorics;Complex;Computer Models;connectome;Data;Deglutition;Electrodes;Elements;Environment;Failure;Feedback;feeding;Feeding behaviors;Food;Future;Ganglia;Hodgkin-Huxley model;Human;Implant;improved;insight;Interneurons;Investigation;Learning;mathematical analysis;mechanical load;Mechanics;Mediating;Memory;Michigan;Modeling;Monitor;Motivation;Motor;motor behavior;Motor Neurons;Movement;multidisciplinary;Nervous System;neural;neural circuit;neural model;Neural Network Simulation;Neuromechanics;neuronal patterning;Neurons;new technology;novel;novel strategies;Pattern;predictive modeling;Preparation;Process;Regulation;Research;response;Role;Satiation;sensory input;sensory stimulus;Shapes;Specific qualifier value;Spinal Cord;Stimulus;success;Synapses;System;Techniques;Testing;Texas;Vertebrates;voltage sensitive dye;Work

PROJECT_TITLE: A novel approach to analyzing functional connectomics and combinatorial control in a tractable small-brain closed-loop system


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Genetics;Human Genome;Immunization

ORG_CITY: Research Triangle Park

ORG_NAME: EPICYPHER, INC.

ORG_STATE: NC

PHR: PROJECT NARRATIVE  Stimulation-responsive histone post-translational modifications (PTMs), including histone phosphorylation, play important roles in the immune response. However, studying these PTMs in primary immune cells, especially in rare cell types, is currently challenged by the limitations of existing chromatin profiling methods. Here, EpiCypher is developing EpiPrime-seq, an ultra-sensitive genomics platform that will enable the study of stimulation-responsive PTMs in primary cells for immunology research, including drug, biomarker, and vaccine development.

PI_NAMEs: KEOGH, MICHAEL-CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Antibodies;Atlases;Bar Codes;Binding;Biological Assay;biomarker development;Cell Line;Cell Separation;cell type;Cells;ChIP-seq;Chromatin;chromatin immunoprecipitation;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;Collaborations;cross reactivity;Development;Disease;DNA;drug development;Epigenetic Process;epigenomics;Failure;Gene Expression;Genes;Genome;genomic platform;Histones;Immune;Immune response;Immune System Diseases;Immunologic Stimulation;Immunologics;Immunology;improved;Inflammatory;innovation;Lysine;Macrophage;Manuals;Maps;Marketing;Methods;Modification;Monitor;Nature;Noise;novel;nuclease;Nucleosomes;Phase;Phosphorylation;Play;Population;Post Translational Modification Analysis;Post-Translational Protein Processing;Protocols documentation;Reaction;Reagent;Recovery;Regulation;Research;Role;Services;Signal Transduction;Sorting;Technology;Testing;Titrations;tool;vaccine development;Validation;validation studies;Work

PROJECT_TITLE: Quantitative mapping of dynamic epigenetic states in rare and stimulated immune cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-D(10)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Infant Mortality;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Right ventricular dysfunction is an important determinant of long-term outcomes in patients with many forms of congenital heart disease. Our research will explore how genotypes affect right ventricular function, survival, and clinical outcomes. We will also test the effect of genotypes in human induced pluripotential stem cell- derived cardiomyocytes, providing functional evidence of how genotypes influence cardiac performance, and developing a resource for future testing of drugs and small molecules targeted at improving deficits.

PI_NAMEs: NEWBURGER, JANE W. (contact);ROBERTS, AMY E;SEIDMAN, CHRISTINE E

PROGRAM_OFFICER_NAME: SCHWARTZ, BRYANNA NICOLE

PROJECT_TERMS: Acceleration;Accounting;Adult;Affect;Anatomy;ATAC-seq;Atrial Flutter;Atrial Tachycardia;Autopsy;Bioinformatics;Biological Assay;Biological Models;Biology;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;Cardiac Surgery procedures;Cells;Child;Chromatin;Chronic;Clinical;clinical database;clinical risk;cohort;comorbidity;Complement;Complex;Congenital atresia of pulmonary valve;congenital heart abnormality;Data;de novo mutation;Development;disease model;drug testing;Electric Countershock;Event;functional outcomes;Future;Gene Expression;Genes;Genetic;Genetic Databases;genetic information;Genetic Transcription;genetic variant;Genomics;Genotype;Heart;Heart Atrium;Heart failure;heart function;Heart Transplantation;hemodynamics;Human;human induced pluripotent stem cells;Hypoplastic Left Heart Syndrome;Image;improved;in vivo;indexing;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;insight;Intervention;life span;malformation;Measures;Metabolism;Molecular Analysis;Morbidity - disease rate;mortality;mouse model;Myocardial;New York;Nuclear;Operative Surgical Procedures;Outcome;Parents;Participant;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Patients;Penetrance;Performance;Perioperative;personalized medicine;Physiological;Play;pluripotent stem cell differentiation;primary outcome;proband;prospective;rare variant;Recurrence;Regulation;Relaxation;repaired;Research;Resources;respiratory;response;Right Ventricular Dysfunction;Right Ventricular Function;Risk;Risk Factors;risk stratification;risk variant;Role;secondary outcome;Signal Transduction;small molecule;study population;success;Tachyarrhythmias;Testing;Tetralogy of Fallot;Tissues;translational therapeutics;Transplantation;Variant;Ventricular;Ventricular Ejection Fractions;Ventricular End-Systolic Volumes;Ventricular Function;Ventricular Remodeling;Ventricular Tachycardia

PROJECT_TITLE: Genomic Effects on  Right Ventricular Function, Clinical Features and Outcomes in CHD


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Mental Health;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: Project Narrative Adaptive control of behavior is critical for survival and requires not only brain control of muscle activity, but also descending control of organism physiology and internal organ function. We will dissect the neural circuits and principles governing the learning and adaptive “motor” control of internal organ function by investigating conditioned insulin release and conditioned immunosuppression, mediated by the innervation of the pancreas and spleen, respectively. We will employ state-of-the art viral tracing methods to map first, second and third- order innervation of spleen and pancreas, RNA sequencing to characterize neuron identity, in vivo calcium imaging to measure neuronal activity in descending circuits, and chemo- and optogenetic tools to causally test how descending circuits impact splenic and pancreatic function.

PI_NAMEs: COSTA, RUI M.  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Adaptive Behaviors;Anatomy;Animals;Anxiety;Apple;Area;arm;Award;Behavior Control;Behavioral;Brain;brain control;Chest;conditioning;expectation;Food;Genetic;Health;Homeostasis;Immunosuppression;in vivo calcium imaging;innovation;Insulin;internal control;Learning;Maps;Measures;Mediating;Mental Depression;Mental disorders;Mesentery;Methods;Motor;motor control;Motor Cortex;Movement;Muscle;nerve supply;Nervous System;neural;neural circuit;Neurologic;Neurons;novel;Optics;optogenetics;Organ;Organism;Pancreas;Physiological;Physiology;Population;Positioning Attribute;Research;Resolution;response;Sensory;Spinal Cord;Spleen;Stroke;Sympathetic Ganglia;Testing;tool;transcriptome sequencing;Viral

PROJECT_TITLE: Brain control of internal organ function


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Prevention;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Overtreatment of patients with low-risk thyroid cancer by removing the entire thyroid puts patients at significant for harm without improving length of life. This pilot study aims to address this problem by evaluating the feasibility and acceptability of a novel intervention to support patient awareness, activation, and preparedness for treatment decision-making. The findings will inform a large-scale clinical trial to test the effect of this intervention on patients’ treatment decisions and rates of total thyroidectomy.

PI_NAMEs: PITT, SUSAN C (contact)

PROGRAM_OFFICER_NAME: EVERSON, NICOLE MARIE

PROJECT_TERMS: acceptability and feasibility;Address;Age;American;Award;Awareness;Behavior;Behavior Therapy;cancer care;Cancer Survivor;care costs;Caregivers;Clinic;Clinic Visits;Clinical;Clinical Trials;cohort;Collaborations;Communication;Communities;Consult;cost;Data;Data Collection;Decision Making;Deimplementation;Diagnosis;disability;evidence base;Expectancy;experience;Fatigue;Feasibility Studies;Future;Goals;Health;Health system;improved;Individual;innovation;Intervention;intervention effect;Intervention Studies;Interview;Knowledge;Language;Longevity;Malignant neoplasm of thyroid;Malignant Neoplasms;Measures;Methodology;Mission;Morbidity - disease rate;multidisciplinary;novel;Operative Surgical Procedures;Outcome;overtreatment;Papillary thyroid carcinoma;Participant;Patient Preferences;Patients;Pilot Projects;Positioning Attribute;pragmatic efficacy trial;primary outcome;Procedures;Process;Protocols documentation;Provider;psychosocial;Qualifying;Quality of life;Randomized;Randomized, Controlled Trials;Readiness;Recommendation;Recording of previous events;recruit;Recurrence;Research;Risk;secondary outcome;Self Efficacy;shared decision making;Side;Site;social cognitive theory;Structure;Surgeon;Survivors;Testing;therapy design;Thyroid Gland;Thyroidectomy;Time;treatment as usual;treatment choice;treatment risk;ultrasound;uptake;Visit;Vocal Cord Paralysis;Work

PROJECT_TITLE: A Pilot Feasibility Study of an Intervention to Decrease Overtreatment of Low-risk Thyroid Cancer


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Precision Medicine;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: The goal of this project is to develop tumor forecasting methods to predict and optimize the response of glioblastoma multiforme to standard-of-care therapies, and do so on a patient-specific basis. We will provide the clinical and scientific community with a validated mathematical description of glioma progression that can reliably predict regional tumor progression and therapy response across a range of relevant glioma signaling pathways and can be readily applied in the clinical setting.

PI_NAMEs: QUARLES, CHRISTOPHER CHAD (contact);YANKEELOV, THOMAS E

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: 3-Dimensional;Address;angiogenesis;Area;Biological;Biological Process;Blood Vessels;Brain;Brain Neoplasms;Calibration;Cellularity;Characteristics;chemotherapy;Clinical;clinical application;Communities;contrast enhanced;Data;Disease;Evolution;Failure;Family;fluorescence imaging;Future;Genetic;Glioblastoma;Glioma;Goals;Human;Hypoxia;Image;in vivo;Individual;individual patient;individual response;Infrastructure;Invaded;Magnetic Resonance Imaging;Malignant neoplasm of brain;mathematical model;Mathematics;Methods;Modeling;Necrosis;neoplastic cell;novel;optical imaging;Patient Care;patient derived xenograft model;patient response;Patients;Positioning Attribute;pre-clinical;predicting response;Prediction of Response to Therapy;predictive modeling;programs;Proliferating;Protocols documentation;Radiation;Radiation therapy;radiological imaging;Radiology Specialty;Resolution;response;Signal Pathway;spatiotemporal;standard of care;success;Techniques;temozolomide;Testing;therapy resistant;Time;Tissues;tool;Translations;treatment optimization;Treatment Protocols;treatment response;tumor;Tumor Burden;tumor growth;tumor heterogeneity;tumor progression;Validation;Vision;Visualization

PROJECT_TITLE: Imaging-based tumor forecasting to predict brain tumor progression and response to therapy

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Genetics;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Pulmonary Hypertension;Rare Diseases

ORG_CITY: HERSHEY

ORG_DEPT: PEDIATRICS

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: NARRATIVE  Extreme preterm infants with bronchopulmonary dysplasia (BPD) or chronic lung disease of prematurity develop pulmonary hypertension (BPD-PH) as a serious complication that results in high mortality and serious illness. Our study seeks to identify extreme preterm infants who are at risk for developing BPD-PH early, and help determine appropriate interventions that could treat BPD-PH and improve their long-term outcomes.

PI_NAMEs: SIDDAIAH, ROOPA  (contact)

PROGRAM_OFFICER_NAME: SANTOS SCHMIDT, AUGUSTO FREDERICO

PROJECT_TERMS: 1 year old;Admission activity;Age;Alveolar;angiogenesis;aspirate;biological adaptation to stress;Biological Markers;biomarker identification;biomarker panel;Biometry;Bronchopulmonary Dysplasia;career;career development;Cell Proliferation;Cells;Cessation of life;Childhood;classification trees;Clinical;Clinical Research;Clinical Trials;Complex;Complication;Correlation Studies;Data;design;Development;Development Plans;Diagnosis;differential expression;Disease;Early identification;Echocardiography;Etiology;experience;extreme prematurity;Extremely low gestational age newborn;Feasibility Studies;Foundations;Future;Gene Expression;Genes;Genetic;Genetic Risk;genomic data;Goals;Growth Factor Gene;high risk;Home;hospital readmission;Hypoxia;improved;improved outcome;in silico;Incidence;Infant;Insulin;interest;Intervention;intraamniotic infection;Intubation;Journals;Learning;Life;Logistic Regressions;longitudinal analysis;Lung;lung development;Master of Science;Medical;meetings;Mentors;MicroRNAs;migration;Modeling;Molecular;molecular marker;Morbidity - disease rate;mortality;multidisciplinary;multiple omics;neonatal care;Neonatal Intensive Care Units;neonate;Outcome;Oxygen;Pathologic;Pathway Analysis;Pathway interactions;Pediatrics;Peer Review;Physicians;Population;Pre-Eclampsia;predictive marker;Predictive Value;Pregnancy;Premature Infant;Prevalence;Prognostic Marker;Prospective Studies;Publishing;Pulmonary Hypertension;pulmonary vascular disorder;Recording of previous events;recruit;Regression Analysis;regression trees;Regulation;Research Project Grants;respiratory;Risk;risk prediction;risk stratification;routine screening;Saliva;saliva sample;Salivary;Sampling;Scientist;screening;Small for Gestational Age Infant;Statistical Data Interpretation;Stratification;Subgroup;Testing;tool;Trachea;Tracheostomy procedure;Training;transcriptome sequencing;Transforming Growth Factor beta;Translational Research;treatment response;Untranslated RNA;vascular bed;Vascular Endothelial Growth Factors;Ventilator;Very Low Birth Weight Infant;Vulnerable Populations;Work

PROJECT_TITLE: Salivary miRNAs as Prognostic Markers of Pulmonary Hypertension Associated with Bronchopulmonary Dysplasia in Extremely Low Gestational Age Infants

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: CLEVELAND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Narrative Protein arginylation is increasingly recognized as a global biological regulator essential for physiological processes, including angiogenesis, embryogenesis, aging, and cell migration. ATE1 is the sole enzyme responsible for protein arginylation and has recently been implicated in human cancers and neurodegenerative diseases, but its catalytic mechanism and regulation remain poorly understood. This project aims to understand the structural, catalytic, and regulatory mechanisms of protein arginylation, which may lead to new therapeutic strategies for preventing the development and progression of Parkinson’s disease and Metastatic Cancer.

PI_NAMEs: ZHANG, YI  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Affect;Aging;Amino Acids;Aminoacylation;angiogenesis;Arginine;Autophagocytosis;Autophagosome;Biochemical;Biological;biological adaptation to stress;biophysical techniques;cell motility;Cell Physiology;Cells;cofactor;Degradation Pathway;Development;Disseminated Malignant Neoplasm;Embryonic Development;Enzymes;Event;Human;In Vitro;Kinetics;Knowledge;macromolecule;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Modeling;Molecular;multicatalytic endopeptidase complex;Neurodegenerative Disorders;novel therapeutic intervention;Nutrient;Parkinson Disease;Pathway interactions;Patients;Physiological Processes;Polyubiquitination;Post-Translational Protein Processing;prevent;Protein Biosynthesis;protein degradation;Proteins;Reaction;Regulation;Research;Ribosomes;Role;Shapes;Site;Skin Cancer;Stress;Transfer RNA;Transfer RNA Aminoacylation;Transferase;Translations;Ubiquitination

PROJECT_TITLE: Arginyl-tRNA beyond translation: mechanism and regulation of protein arginylation

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease

ORG_CITY: Chicago

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The Chronic Renal Insufficiency Cohort (CRIC) Study enrolled more than 5500 adults with chronic kidney disease (CKD) to address overarching goals of identifying predictors of rapid progression of kidney disease and clarifying the relationship between kidney disease and the risks of cardiovascular events and death. During the earlier phases of CRIC, the UIC Clinical Center research team has been successful in terms of recruitment, retention, data quality, a strong focus on heath disparities in CKD, and scientific productivity. This proposal for the next phase will extend follow-up for another three years during which we will conduct data analyses with integration of findings from home testing done during the prior phase, and final study visits.

PI_NAMEs: LASH, JAMES P. (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Achievement;Address;Adult;Affect;Ancillary Study;Arrhythmia;Biological;Cardiovascular Diseases;Cardiovascular Manifestation;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chicago;Chronic Kidney Failure;Chronic Kidney Insufficiency;Chronic Phase;Clinical;clinical center;Clinical Research;cohort;Cohort Studies;Collaborations;Communities;comorbidity;Data;Data Analyses;Data Collection;data integration;data quality;Data Sources;design;Development;Disease Progression;Eligibility Determination;Enrollment;Ensure;Epidemiology;epidemiology study;ethnic diversity;Event;Evolution;follow-up;Funding;Future;Goals;health data;health disparity;Heterogeneity;Home;home test;Illinois;Individual;innovation;Institution;Investigation;Kidney;kidney biopsy;Kidney Diseases;Kidney Function Tests;Laboratory Research;Leadership;Link;Measurement;Measures;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Observational epidemiology;Outcome;Output;Parents;Participant;participant enrollment;Pathway interactions;Patient-Focused Outcomes;Phase;Phenotype;phenotypic data;Physicians;Physiological;Positioning Attribute;precision medicine;Process;Productivity;programs;Prospective cohort;Prospective Studies;Prospective, cohort study;Protocols documentation;Publications;racial diversity;recruit;renal damage;Renal function;repository;Research;Research Personnel;Resources;response;Risk Factors;Scientist;Site;social;Source;tool;Translational Research;Universities;Visit

PROJECT_TITLE: Continuation of the University of Illinois Chicago CRIC Clinical Center


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Metastatic outgrowth of tumor cells requires nutrients to fuel cell proliferation. Blood vessels play a critical role in supplying nutrients. This application investigates how mTORC1, a signaling molecule, in regulating fatty acids transport across blood vessel to support tumor metastasis.

PI_NAMEs: CHEN, JIN  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Affect;Amino Acids;Antibodies;Antigens;Automobile Driving;Back;Binding;Biomass;Blood Vessels;BODIPY;cancer cell;cancer therapy;CD36 gene;Cell Proliferation;Cells;chemotherapy;Clinic;Collaborations;Confocal Microscopy;Data;Detection;Development;Distant;Dose;Endothelial Cells;Endothelium;FABP3 gene;fatty acid metabolism;fatty acid transport;fatty acid-transport protein;Fatty Acids;Fluorescence;Functional disorder;Future;Glucose;Glutamine;Human;Immune;Immunotherapy;improved;In Situ;in vivo;Inhibition of Cell Proliferation;innovation;KDR gene;Knock-out;Lipids;Location;long chain fatty acid;LoxP-flanked allele;Lung;mass spectrometric imaging;Mediating;Membrane Proteins;Metabolic;Metabolism;metabolomics;Modeling;mouse model;Mus;Neoplasm Metastasis;Neoplasms in Vascular Tissue;neoplastic cell;neutralizing antibody;Nutrient;Nutritional Requirements;Organ;Palmitates;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Play;Polyunsaturated Fatty Acids;Population;Production;Regulation;Role;Signal Transduction;Signaling Molecule;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stream;System;T cell therapy;T-Lymphocyte;Techniques;Technology;Testing;Total Internal Reflection Fluorescent;Trans Fatty Acids;transcriptome sequencing;Transportation;tumor;tumor microenvironment;uptake;Vascular Endothelial Cell;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelium;Vascular System;Work

PROJECT_TITLE: Vascular regulation of fatty acid transport in metastatic tumor outgrowth

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative This proposal outlines a training and research plan to determine the effects of psychosocial stressors on Alzheimer’s Disease and related dementias (ADRD), including the total effects, whether social networks buffer that effect, and whether sleep disturbance is a pathway from psychosocial stressors to ADRD. The research is relevant to NIA’s mission and the priority of the 2012 National Alzheimer’s Project Act to address social disparities in ADRD.

PI_NAMEs: CHEN, RUIJIA  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Academic skills;Acceleration;Address;Adult;Adverse effects;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Asian population;Attention;Award;Behavioral Sciences;biobehavior;Black Populations;Buffers;California;career;childhood adversity;Cognitive;Cognitive aging;cognitive function;Complex;Data;Dementia;dementia risk;Development;Disadvantaged;disadvantaged background;Disparity;Disparity population;doctoral student;effective therapy;Epidemiologist;Epidemiology;ethnic minority;Ethnic Population;experience;Face;Fellowship;Funding;Grant;health disparity;healthy aging;high risk;Impaired cognition;Individual;Inequality;Intervention;Knowledge;late life;Latino Population;Life;Life Cycle Stages;Life Experience;life span;Link;longitudinal analysis;Longitudinal cohort;Measurement;Mediating;Mediation;Mental Health;Mentorship;Methods;middle age;Mission;Modeling;multidisciplinary;neurogenesis;novel;older adult;Outcome;Pathway interactions;physical conditioning;Physiology;Play;Postdoctoral Fellow;Psychology;Psychometrics;psychosocial;Psychosocial Stress;psychosocial stressors;racial diversity;racial minority;racial population;Research;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;resilience;Risk Assessment;Risk Factors;Role;Sampling;Senile Plaques;skills;Sleep;Sleep Apnea Syndromes;Sleep disturbances;Sleeplessness;social disparities;Social Network;social network intervention;Social Sciences;Societies;socioeconomics;Source;Stress;stressor;Structure;Time;Training;Treatment/Psychosocial Effects;United States;Work

PROJECT_TITLE: Lifecourse Stressors and Social Disparities in Cognitive Aging: The Roles of Social Networks and Sleep Disturbance


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE The following project will decipher how a tRNA modification enzyme complex recognizes its substrate and the functions of the catalyzed modification. These discoveries will provide a foundation for understanding the molecular roles of a vertebrate-specific tRNA modification required for proper neurodevelopment in humans.

PI_NAMEs: FU, DRAGONY  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;Alleles;Amino Acyl-tRNA Synthetases;Aminoacylation;Anticodon;Arginine;autosome;Binding;Biological;Biology;Brain;Brain Diseases;brain tissue;Cells;Chemicals;Codon Nucleotides;Complex;Development;Developmental Delay Disorders;Disease;Elements;Ensure;Enzymes;Epilepsy;epileptic encephalopathies;Exhibits;Foundations;Genes;genetic variant;Goals;Health;Human;Individual;insight;Knock-out;Link;loss of function;Mammalian Cell;Measures;Mediating;Messenger RNA;Methylation;Methyltransferase;Modification;Molecular;Molecular Biology;Molecular Conformation;Monitor;Mouse Strains;Multienzyme Complexes;Mus;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;Neurologic;novel;Organ;Pathogenicity;Pathology;Patients;Physiological;Play;Protein Biosynthesis;Proteins;recruit;Reporter;Research;Ribosomal Interaction;ribosome profiling;Ribosomes;RNA Biochemistry;RNA Conformation;RNA Folding;RNA methylation;RNA Sequences;RNA Stability;Role;Structure;Testing;Therapeutic;Transfer RNA;Translations;Variant

PROJECT_TITLE: Mechanism and functions of DALRD3-dependent tRNA modification

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative: The establishment of specialized chromatin domains referred to as heterochromatin is critical for centromere and telomere function, silencing of repetitive DNA and maintaining lineage-specific patterns of gene expression. Our program of research aims to develop a basic understanding of the mechanisms that govern how cells memorize epigenetic patterns of gene expression. This research is relevant to human health since disrupting heterochromatin formation leads to chromosome segregation defects and genome instability which are the most common of abnormalities observed in cancer cells.

PI_NAMEs: RAGUNATHAN, KAUSHIK  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Aneuploidy;Belief;Binding;Biochemistry;cancer cell;Cell Differentiation process;Cells;Centromere;Chromatin;Chromosome Segregation;Complex;Defect;Development;DNA;Elements;epigenetic memory;Epigenetic Process;epigenome;Gene Expression Profile;Generations;Genetic Transcription;Genome;Genomic Instability;Health;Heritability;heritability pattern;Heterochromatin;Histone H3;histone modification;Histones;Human;In Vitro;Individual;Lysine;Maintenance;Malignant Neoplasms;Methodology;Methylation;Microfluidics;molecular imaging;Nucleosomes;Pattern;preservation;Process;programs;Property;protein protein interaction;Reader;reconstitution;Research;Role;scaffold;single molecule;Site;synergism;telomere;temporal measurement;Time;transmission process;Visualization

PROJECT_TITLE: Capturing the dynamic epigenome using single molecule and single cell approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cachexia;Clinical Research;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: CHICAGO

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

PHR: Project Narrative Mortality and morbidity are independently linked to cachexia, a muscle wasting syndrome present in many patients with chronic diseases. In this proposal, we examine how muscle tissue extracellular matrix remodeling may act as a barrier to response to therapy or exercise during the end stages of cachexia. Our findings will help develop new rehabilitation strategies that can be implemented across the spectrum of cachexia disease.

PI_NAMEs: ROY, ISHAN  (contact)

PROGRAM_OFFICER_NAME: EISENSTEIN, JANA S

PROJECT_TERMS: Affect;age related;Animal Model;Animals;Anti-Cytokine Therapy;Anti-Inflammatory Agents;antifibrotic treatment;Antiinflammatory Effect;Articular Range of Motion;autocrine;Biological Assay;Biological Models;Biology;Blocking Antibodies;Cachexia;Cancer Biology;Cancer Patient;career;career development;Chronic Disease;chronic infection;Clinical;Clinical Trials;cohort;Collagen;crosslink;cytokine;Development;Disease;disease model;Disuse Atrophy;Doctor of Philosophy;Elasticity;Elements;endurance exercise;Exercise;exercise intervention;exercise regimen;extend lifespan;Extracellular Matrix;Failure;Fiber;Fibroblasts;Fibrosis;Frequencies;functional decline;Future;Goals;Hand Strength;Histology;Human;Hydroxyproline;Hypertrophy;IL-6 inhibitor;Immune system;Immunology;implantation;improved;in vivo;Individual;Inflammation;Inflammatory;inhibitor;Interleukin-1;Interleukin-6;Intervention;Intramuscular;K-Series Research Career Programs;Knowledge;Link;Losartan;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mechanics;Mentors;Mentorship;Modeling;Morbidity - disease rate;mortality;mouse model;multimodality;Mus;Muscle;Muscle Development;Muscle function;muscle physiology;Muscle rehabilitation;Muscular Atrophy;novel;Organ failure;pancreatic cancer patients;Patients;Phase;Phenotype;Physical Function;Physical Medicine;Physical Rehabilitation;Physicians;Physiology;Play;Pre-Clinical Model;preclinical evaluation;prevent;professor;Proliferating;Protein-Lysine 6-Oxidase;Refractory;rehabilitation strategy;Resistance;resistance exercise;response;Role;Rotarod Performance Test;Running;sarcopenia;Scheme;Science;Scientist;Signal Transduction;Skeletal Muscle;skills;success;Syndrome;systemic inflammatory response;Testing;Tissues;Titrations;TNF gene;Training;Transforming Growth Factor beta;treadmill;treatment response;Universities;wasting;Wasting Syndrome;Weight;Weight-Bearing state;Work

PROJECT_TITLE: Muscle Fibrosis in Cachexia

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Genetics;Lung;Pulmonary Hypertension;Rare Diseases;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is primarily a chronic lung disease that occurs more in female patients than males (4:1 ratio). Here we propose that Uty gene on the Y chromosome protects from pulmonary hypertension, and aim to identify downstream effector genes of Uty that could serve as novel therapeutic targets in attenuating PAH in male and female patients.

PI_NAMEs: EGHBALI, MANSOUREH  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Alveolar Macrophages;angiogenesis;Angiogenesis Inhibition;Animal Model;antagonist;Apoptosis;Bioinformatics;Bone Marrow;bosentan;Candidate Disease Gene;Cell Death;Cell Proliferation;Cell Separation;cell type;Cells;Cessation of life;Chromosomes;Chronic lung disease;cohort;Collaborations;CXCL9 gene;cytokine;Data;Data Set;Development;Endothelial Cells;Endothelin Receptor Antagonist;Endothelin-1;Endothelin-2;Endothelium;Estrogens;Eye;Female;Functional disorder;Genes;Gonadal Hormones;Gonadal Steroid Hormones;Health;Hormones;Human;Incidence;Incubated;Inflammatory;innovation;knock-down;Knockout Mice;Lung;lung hypoxia;lung microvascular endothelial cells;Macrophage;male;Micro Array Data;mouse model;Mus;myometrium;new therapeutic target;Pathogenesis;Pathologic Neovascularization;Patients;Pilot Projects;Proliferating;protective effect;protective factors;Publishing;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary Hypertension;Rattus;receptor;Recombinants;response;right ventricular failure;Right Ventricular Hypertrophy;Role;Sampling;Severities;sex;Sex Chromosomes;Sex Differences;Smooth Muscle Myocytes;Testing;Therapeutic Uses;Time;transcriptome sequencing;Transgenic Organisms;Up-Regulation;Vascular Endothelial Cell;vascular smooth muscle cell proliferation;Wild Type Mouse;women patients;women versus men;Work;Y Chromosome

PROJECT_TITLE: Role of Chromosome Y gene, Uty, in protecting against Pulmonary Hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Public Health Relevance The United States faces an unprecedented drug addiction crisis, with one potent driver of relapse to drug-seeking the environmental context in which the effects of a particular drug were experienced. However, the circuit mechanism underlying this behavior remains incompletely understood. Here, we propose to apply cutting-edge technology to explore how the well-known reward-circuity, and its associated neuromodulators, interface with the hippocampus, a region that encodes environmental context and is ideally poised to engage with reward-related signals to form memories for later action selection based on learned associations.

PI_NAMEs: GIOCOMO, LISA  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Address;Animals;Automobile Driving;Axon;Behavior;Behavioral;Biophysics;Biosensor;Brain;Brain region;Calcium;Calcium Signaling;Cells;Code;Complex;Data;Decision Making;Detection;Dopamine;Drug Addiction;drug relapse;Drug usage;Electrophysiology (science);Environment;experience;Face;Fire - disasters;Food;Future;Hippocampus;Home;Human;Image;Individual;innovation;insight;Learning;Link;Location;locus ceruleus structure;Maps;medial temporal lobe;Mediating;member;Memory;Mental disorders;Midbrain structure;Mus;nerve supply;neural;Neuromodulator;Neurons;neuroregulation;noradrenergic;Norepinephrine;optogenetics;Pathologic;Pharmaceutical Preparations;place fields;Population;Positioning Attribute;public health relevance;Relapse;Research;Rest;reward processing;Rewards;Role;Sensory;Shapes;Signal Transduction;Source;Stimulus;Structure;System;Technology;temporal measurement;Testing;Time;two-photon;United States;Ventral Tegmental Area;virtual environment;virtual reality;way finding;Work

PROJECT_TITLE: Precise neuromodulation for encoding reward in the hippocampus

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: OVERALL - PROJECT NARRATIVE An effective vaccine remains the most direct and cost-effective way to end the HIV/AIDS pandemic. Our Cytomegalovirus (CMV) vector-based HIV/SIV vaccine has shown a unique form of viral “replication arrest” efficacy in the Rhesus Macaque-SIV model mediated by an unconventional CD8+ T cell population that recognizes viral epitopes in the context of major histocompatibility complex E proteins. The work proposed in this application will delineate the immune mechanisms underlying this novel efficacy, which will then be used to guide human testing of this vaccine concept in ongoing and future phase I/II trials.

PI_NAMEs: PICKER, LOUIS J. (contact)

PROGRAM_OFFICER_NAME: PENSIERO, MICHAEL N

PROJECT_TERMS: adaptive immune response;AIDS prevention;Animals;Applications Grants;Autopsy;Bioinformatics;Biotechnology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Cercopithecine Herpesvirus 1;Characteristics;clinical development;clinical efficacy;clinical translation;Communicable Diseases;cost;cost effective;Cytomegalovirus;data management;DNA;E protein;efficacy evaluation;efficacy trial;Electroporation;Epitopes;Experimental Models;Extinction;Frequencies;Future;Gene Modified;Genetic Programming;Haplotypes;Herpesviridae;HIV;HIV vaccine;HIV/AIDS;HIV/SIV vaccine;Human;Immune;Immune response;Immunobiology;immunogenicity;Immunologics;immunoregulation;Immunotherapy;in vivo;Infection;interest;Interleukin-15;Macaca mulatta;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Memory;Modeling;Mucous Membrane;Myeloid Cells;Natural Killer Cells;Nature;novel;pandemic disease;Pathogenicity;Pattern;Phase;Phase I/II Trial;Phenotype;Population;Process;programs;Publishing;Research;research clinical testing;response;Rhesus;Role;Signal Transduction;SIV;SIV Vaccines;T cell differentiation;T cell response;T memory cell;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Time;Tissues;transcriptomics;transmission process;Vaccinated;Vaccination;vaccine development;vaccine efficacy;vaccine evaluation;Vaccines;vector;vector induced;vector vaccine;vector-based vaccine;Viral;Viral Vector;Viremia;Virus;Virus Replication;Whole Blood;Work

PROJECT_TITLE: Immunologic and Virologic Basis of RhCMV/SIV Vaccine-Induced Replication Arrest Efficacy


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Rehabilitation

ORG_CITY: HARTFORD

ORG_NAME: HARTFORD HOSPITAL

ORG_STATE: CT

PHR: A core characteristic of autism spectrum disorder (ASD) is a deficit in mentalizing (our ability to create mental representations of others), which we have identified an underlying neural network with our pilot functional magnetic resonance imaging data. This proposal is a robust investigation into modulating this network with repetitive transcranial magnetic stimulation sequences to uncover the optimal method to target and modulate the mentalizing network activity in ASD. Validating this neural mechanism in ASD is a necessary first step toward assessing the effectiveness of repetitive transcranial magnetic stimulation in modulating social behaviors in this group in future clinical studies.

PI_NAMEs: ASSAF, MICHAL  (contact);STEELE, VAUGHN R

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Adult;adult with autism spectrum disorder;Affect;Age;Area;autism spectrum disorder;Behavior;Behavior Therapy;Bilateral;Brain;Brain region;Characteristics;cingulate cortex;Clinical Research;cognitive process;Data;design;Diagnosis;Double-Blind Method;effective intervention;effectiveness evaluation;electric field;Emotions;Functional Magnetic Resonance Imaging;functional MRI scan;Future;High Prevalence;Impairment;Individual;individuals with autism spectrum disorder;Investigation;Left;Life;Medial;mental representation;mentalization;Methods;Mind;Modeling;Motivation;MRI Scans;neural;neural circuit;neural network;neuromechanism;noninvasive brain stimulation;Participant;Patient Self-Report;Patients;Prefrontal Cortex;Process;Publishing;recruit;repetitive transcranial magnetic stimulation;Reporting;Research;Rest;Role;Sampling;Scanning;Schedule;Schizophrenia;side effect;skills;social;Social Behavior;social cognition;social communication;social deficits;Social Interaction;Structure of superior temporal sulcus;success;Symptoms;theory of mind;Transcranial magnetic stimulation;Treatment Efficacy;young adult

PROJECT_TITLE: Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder using Transcranial Magnetic Stimulation

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Advisory Committees;Charge;clinical development;collaborative environment;Communication;Cytomegalovirus;data curation;data sharing;Databases;Decision Making;Ensure;Fostering;Grant;HIV;Human;Human Resources;Immunologics;Institution;Leadership;Maintenance;Manuscripts;meetings;National Institute of Allergy and Infectious Disease;Phase;Program Research Project Grants;programs;Progress Reports;Qualifying;Quality Control;Reporting;research clinical testing;Scientific Advances and Accomplishments;Scientific Evaluation;Scientist;SIV Vaccines;Statistical Data Interpretation;success;Supervision;Travel;United States National Institutes of Health;vector;vector vaccine;videoconference;Visit;Writing

PROJECT_TITLE: Admin Core


PI_NAMEs: AXTHELM, MICHAEL K (contact)

PROJECT_TERMS: Animal Housing;Animal Model;Animals;Autopsy;CD8-Positive T-Lymphocytes;Cells;Clinical;Clinical Data;Clinical Management;Communicable Diseases;Complex;Data;Data Analyses;Data Collection;Discipline;efficacy research;Elements;Ensure;Epitopes;Event;experience;experimental study;Goals;HIV-1;Human;Human Resources;Immune;Immunize;Immunologics;in vivo;Infection;Infrastructure;Interleukin-15;Investigation;Lead;Leadership;Macaca mulatta;Mediating;Mission;Modeling;nonhuman primate;novel;Pathologic;Performance;Physiological;Procedures;Program Research Project Grants;programs;Protocols documentation;Quality Control;Records;Research;Research Personnel;response;Risk;Role;Safety;sample collection;Sampling;Signal Transduction;simian human immunodeficiency virus;SIV;SIV Vaccines;Specimen Handling;Structure;Supervision;T-Lymphocyte;Technical Expertise;Tissues;transcriptomics;Vaccination;vector;Viral;virtual;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Non Human Primate Core


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: ESTES, JACOB D (contact)

PROJECT_TERMS: Adopted;Antigen-Antibody Complex;Atlases;B-Lymphocytes;Bioinformatics;Biology;Biometry;Blood;booster vaccine;CCRL2 gene;CD8-Positive T-Lymphocytes;Cell Communication;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Complex;Computer Models;Cytokine Signaling;Data;Data Analyses;data integration;Data Set;Development;Disease;Flow Cytometry;Gene Expression;Gene Expression Profile;Generations;Genetic Transcription;high dimensionality;Histopathology;HIV;Immune;Immune response;Immune system;Immunization Programs;Immunofluorescence Immunologic;Immunohistochemistry;Immunologics;Immunology;immunoregulation;In Situ;In Situ Hybridization;in vivo;Infection;insight;Intercept;Interleukin-15;Link;Lymphoid Tissue;Macaca mulatta;Maps;Mediating;Microscopy;Modeling;Multiomic Data;nano-string;Nature;Neighborhoods;novel;Output;Pathogenesis;Pathway interactions;Pattern;Periodicity;Phenotype;Population;Process;programs;protein expression;Residual state;Resolution;Signal Transduction;single cell analysis;single-cell RNA sequencing;SIV;SIV Vaccines;System;T cell response;T-Lymphocyte;Tissues;tool;transcriptomics;transmission process;Vaccinated;vaccine efficacy;Vaccines;vector;Viral;Viral Genes;Viral reservoir;virology;Virus;whole slide imaging;Work

PROJECT_TITLE: Advanced Spatial Analysis Core


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE This application seeks to understand how the replication stress response promotes completion of DNA synthesis each cell division cycle while maintaining genome stability. Genome instability causes many diseases including developmental disorders and cancer. Therefore, completing this project will provide insights into basic genome maintenance mechanisms with significant clinical application.

PI_NAMEs: CORTEZ, DAVID K (contact)

PROJECT_TERMS: Back;Base Pairing;Binding;Biochemical;Biological;biological adaptation to stress;cancer therapy;Cell Cycle;cell type;Cells;Chromatin;clinical application;Data;developmental disease;Disease;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair;DNA replication fork;Ensure;Event;Excision Repair;Explosion;Failure;Funding;Future;Genetic;Genetic Transcription;Genome;genome integrity;Genome Stability;Genomic Instability;Genomics;Health;helicase;Human;human disease;improved;innovation;insight;Knowledge;Lesion;Link;Maintenance;Malignant Neoplasms;Modeling;Mutation;Nature;nuclease;Outcome;Pathway interactions;Polymerase;Positioning Attribute;prevent;programs;Property;Publishing;Rad51 recombinase;Reagent;Regulation;repaired;replication stress;Research;Research Personnel;Research Proposals;response;Series;Signal Transduction;Single-Stranded DNA;Source;Speed;SS DNA BP;Stress;stress tolerance;Structure;Testing;tool;Translating;translocase;Work

PROJECT_TITLE: Analysis of the Replication Stress Response

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: GALE, MICHAEL  (contact)

PROJECT_TERMS: antigen-specific T cells;Bar Codes;Big Data;big data management;Bioinformatics;Biological;Biological Assay;Biometry;Blood;Bone Marrow;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;cohort;Computer Analysis;Computer Models;Data;Data Analyses;data curation;data handling;data integration;data management;Data Management Resources;Data Set;Databases;Experimental Designs;functional genomics;Gene Expression;Gene Expression Profile;gene function;Generations;Genes;genomic data;genomic platform;Goals;Gut associated lymphoid tissue;Immune;Immune response;Immune Response Genes;Immunization Programs;Immunologics;Infection;Laboratories;Link;lymph nodes;Macaca mulatta;Measurement;Mediating;Membrane Proteins;Messenger RNA;Methods;Modeling;Monitor;multidimensional data;multiple omics;nano-string;Output;Peptides;pre-clinical;preclinical study;predictive signature;programs;Resolution;response;Secure;SIV;SIV Vaccines;Spleen;Study Subject;T cell differentiation;T cell response;T-Cell Receptor;T-cell receptor repertoire;Tissues;transcriptome sequencing;transcriptomics;Vaccinated;Vaccination;vaccine efficacy;vaccine trial;Vaccines;Virus;web server;web-accessible;Whole Blood;Work

PROJECT_TITLE: Omics, Bioinformatics, and Data Management Core


PI_NAMEs: SACHA, JONAH B. (contact)

PROJECT_TERMS: Address;Antigen-Presenting Cells;Antigens;antiretroviral therapy;Autologous;Autopsy;B-Lymphocytes;Biopsy;Blood Cells;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Clinic;clinical translation;cohort;Cytomegalovirus;Data;Disease remission;DNA;Equilibrium;Extinction;Gene Expression;Gene Expression Profile;Genetic Transcription;Goals;high dimensionality;HIV;HIV vaccine;Immune;Immune response;Immunity;Immunologics;immunoregulation;in vivo;indexing;Infection;Interleukin-15;Link;Macaca mulatta;Major Histocompatibility Complex;Mediating;memory CD4 T lymphocyte;Mononuclear;Myelogenous;Natural Killer Cells;Nature;Outcome;Output;Pattern;Peptides;Phase;Plasma;Population;pre-clinical;prevent;Primary Infection;Process;Production;prophylactic;Residual state;Resistance;Resolution;response;Rest;Rhesus;RNA;Signal Transduction;Site;SIV;T cell receptor repertoire sequencing;T cell response;T memory cell;T-Cell Depletion;T-Cell Receptor;Time;Tissues;transcriptome sequencing;transcriptomics;Translations;Vaccinated;Vaccination;Vaccine Antigen;Vaccines;vector;vector induced;Viral;Viremia;Virion;Virus;Virus Diseases;Virus Replication;Whole Blood

PROJECT_TITLE: Project 1: Immunologic and Virologic Characterization of RhCMV/SIV Vaccine-Mediated SIV Replication Arrest Efficacy


ORG_CITY: WASHINGTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project narrative The establishment of left-right (LR) asymmetry is a critical event required for the correct positioning of internal organs. Defects in human LR axis formation cause birth defects of the heart, vasculature, lungs, and intestinal tract. Our research aims to discover the central mechanism that links Hedgehog (Hh) signaling pathway and transforming growth factor-b (TGF-b) signaling pathway to the establishment of left-right asymmetry.

PI_NAMEs: ZHENG, XIAOYAN  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Affect;Biochemical;Cilia;Competence;Congenital Abnormality;Defect;Development;Developmental Biology;Diagnosis;disability;Drosophila genus;early embryonic stage;Embryo;Embryonic Development;Erinaceidae;Event;Extracellular Matrix Proteins;Fibronectins;fluid flow;Gene Expression;gene network;Generations;Genes;genetic approach;Growth;heart defect;homeodomain;Homologous Gene;Human;Intestines;Knowledge;Lateral;Left;Limb Bud;Link;Location;Lung;Mediating;Mesoderm;Molecular;Morphogenesis;Mus;Neural tube;neuron loss;Neurons;neurotrophic factor;Nodal;novel;Organ;Pathway interactions;Pattern;Play;Positioning Attribute;preventive intervention;Regulation;Research;response;Role;Rotation;secretory protein;Side;Signal Pathway;Signal Transduction;Site;smoothened signaling pathway;Source;Structure;Testing;TGF Beta Signaling Pathway;Therapeutic Intervention;tool;transcription factor;Transcriptional Regulation;Transforming Growth Factor beta;Transforming Growth Factors;Travel;vertebrate embryos;Vertebrates;Wing;Work

PROJECT_TITLE: Linking Hedgehog and Nodal/TGF-beta signaling in the establishment of left-right asymmetry

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


PI_NAMEs: HANSEN, SCOTT G (contact)

PROJECT_TERMS: Autopsy;Bar Codes;Bioinformatics;Biopsy;booster vaccine;CD8-Positive T-Lymphocytes;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;clinical translation;Cytomegalovirus;Data;Development;Dose;Epitopes;Exhibits;genetic manipulation;Genetic Transcription;Goals;high dimensionality;HIV vaccine;Immune;immune activation;Immune response;Immunologics;in vivo;indexing;Infection;Innate Immune Response;insight;Intercept;Interleukin-15;Link;Macaca mulatta;Major Histocompatibility Complex;Mediating;Memory;Modality;Modeling;Mucous Membrane;Pathogenicity;Pattern;Phenotype;predictive signature;Process;programs;response;Rhesus;Sampling;Schedule;Signal Transduction;Site;SIV;SIV Vaccines;T cell receptor repertoire sequencing;T cell response;T-Cell Receptor;T-Lymphocyte;Technology;Tissues;transcriptome;transcriptome sequencing;transcriptomics;unvaccinated;Vaccinated;Vaccination;Vaccinee;Vaccines;vector;Viral;Viremia;Virus;Virus Activation

PROJECT_TITLE: Project 2: Characterization of the in vivo T cell (and overall immune) interception of primary SIV infection after vaccination with differentially response programmed RhCMV/SIV vectors


ORG_CITY: GREENVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: Project Narrative  Hypertension is a major risk factor for cardiovascular diseases such as stroke, heart failure and renal failure. With a greater than 33% prevalence rate in the United States, hypertension remains an increasingly important medical and public health issue. In this proposal, we aim to develop a novel therapeutic approach based on kinin B1 receptor blockade to treat neurogenic hypertension.

PI_NAMEs: SRIRAMULA, SRINIVAS  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Address;Agonist;Angiotensin II;Attenuated;attenuation;Autonomic Dysfunction;blood pressure regulation;Bradykinin;Brain;Brain region;Carboxypeptidase;Cardiovascular Diseases;cardiovascular risk factor;Chronic;cytokine;Data;Development;Disintegrins;Epidermal Growth Factor Receptor;Future;Genetic;Genetic Models;glial activation;Heart failure;Human;human subject;Hypertension;hypertensive;In Vitro;in vivo;Inflammation;Inflammatory;Infusion procedures;insight;interdisciplinary approach;Kidney Failure;Kinins;Knockout Mice;Link;Lysine Carboxypeptidase;Measures;Mediating;Medical;Metalloproteases;Methods;mitochondrial dysfunction;Modeling;Molecular;Morbidity - disease rate;mortality;Mouse Strains;neurogenic hypertension;Neuroimmune;Neuroimmunomodulation;neuroinflammation;Neurons;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Organ;Oxidation-Reduction;Oxidative Stress;paraventricular nucleus;Patients;Peripheral;pharmacologic;Play;Prevalence;prevent;Production;Prognosis;Public Health;receptor;Receptor Activation;receptor expression;Receptor Signaling;Receptor Up-Regulation;receptor upregulation;Receptor, Angiotensin, Type 1;receptor-mediated signaling;Renin-Angiotensin System;Role;salt sensitive hypertension;Signal Pathway;Signal Transduction;Spatial Distribution;Stroke;Sympathetic Nervous System;Techniques;Testing;Therapeutic;Transactivation;United States;Up-Regulation;Vascular Diseases;Work

PROJECT_TITLE: Neuroimmune Mechanisms of Kinin B1 Receptor in Hypertension

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Genetics;Rare Diseases

ORG_CITY: BOSTON

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE This project is to generate a reagent resource that enables the characterization and validation of Drosophila models of human mitochondrial diseases. These reagents will facilitate immunolocalization and immunoprecipitation and be used together with existing RNAi transgenic lines to validate fly models of human mitochondrial diseases. As mitochondrial diseases affect multiple organs, our proposal is relevant to most NIH institutes.

PI_NAMEs: PERRIMON, NORBERT  (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Affect;Affinity;Aging;Alpaca;Animal Model;Base Sequence;Biochemical;Biological Assay;Biological Models;Biomedical Research;Chimeric Proteins;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communities;Complementary DNA;cost effective;Defect;Degenerative Disorder;Detection;Diabetes Mellitus;Drosophila genus;Drug or chemical Tissue Distribution;Enhancement Technology;Epitopes;Exons;experimental study;fly;Functional disorder;gene function;Gene Structure;Genes;Genetic;Genome engineering;Heart failure;Human;human disease;human model;Immunoprecipitation;in vivo;Individual;interest;kidney dysfunction;knock-down;Knock-in;Liver diseases;Mediating;Metabolic Diseases;Mitochondria;Mitochondrial Diseases;Mitochondrial Proteins;Modeling;Morphology;Muscle Weakness;Mutation;nanobodies;Nerve Degeneration;Organ;Orthologous Gene;Pathology;Patients;Phenotype;Premature aging syndrome;Protein Isoforms;Proteins;Protocols documentation;Public Domains;Publishing;R24;Reagent;Reproducibility;Resource Development;Resources;response;RNA Interference;Role;Seizures;Signal Transduction;Technology;Tertiary Protein Structure;Tissues;tool;Transgenic Organisms;United States National Institutes of Health;Validation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(56)R]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Address;Adoptive Immunotherapy;Autologous;Avidity;CD8-Positive T-Lymphocytes;Cells;Characteristics;cross reactivity;Cytomegalovirus Vaccines;design;Development;Disparate;Engineering;Ensure;Epitopes;expression cloning;flexibility;Genetic Polymorphism;Haplotypes;HIV;HIV vaccine;Immune;Immune response;immunogenicity;Immunologics;in vivo;Infection;Infusion procedures;Intercept;Link;Macaca mulatta;Major Histocompatibility Complex;Mediating;Modeling;Mutation;novel;Peptides;programs;response;Rhesus;SIV;SIV Vaccines;Specific qualifier value;Specificity;Structure;Systemic infection;T cell response;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-Lymphocyte;Testing;Time;Vaccinated;Vaccination;vaccine response;Vaccinee;Vaccines;vector;vector vaccine;Viral;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Project 3: Determination of the minimal MHC-E-restricted SIV epitope targeting required for RhCMV/SIV vaccine-mediated SIV replication arrest efficacy


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Glioblastomas (GBM) are the most recalcitrant adult brain tumors affecting about 15,000 Americans every year and exhibit considerable resistance to chemo and radiation therapy. In this proposal, we have identified novel modulators of radiation resistance and propose to use synthetic combinations to target these pathways and sensitize glioma cells to radiation. The overall goal is to use these pre-clinical studies to design new and effective treatment options for patients with GBM.

PI_NAMEs: BHAT, KRISHNA PL;SULMAN, ERIK  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Acid Phosphatase;Address;Adult;Affect;American;Bar Codes;Binding;Brain;Brain Neoplasms;cell killing;Cells;chemoradiation;chemotherapy;Chromatin;Chromatin Remodeling Factor;Clinical;Clinical Trials;clinically relevant;comparative efficacy;CRISPR screen;Data;Data Set;design;DNA Damage;DNA Repair Pathway;Dose;druggable target;effective therapy;Effectiveness;Epigenetic Process;Evaluation;Excision;Exhibits;experimental study;Gene Expression;Gene Expression Profile;Gene Targeting;Genes;Genomics;Glioblastoma;Glioma;Goals;Grant;HMGB2 gene;improved;In Vitro;in vivo;in vivo Model;inhibitor;Ionizing radiation;Knowledge;Laboratories;Link;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mesenchymal;Mesenchymal Differentiation;Metabolic;Modeling;molecular subtypes;Molecular Target;Mus;neoplastic cell;neural;Neuronal Differentiation;novel;Operative Surgical Procedures;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;Phase I Clinical Trials;Phenotype;phosphatase inhibitor;Phosphoric Monoester Hydrolases;Photons;Post-Translational Protein Processing;potential biomarker;pre-clinical;Pre-Clinical Model;preclinical study;programs;protein complex;Radiation;radiation resistance;Radiation therapy;Radiation Tolerance;Radiation-Sensitizing Agents;radioresistant;Radiosensitization;Recurrence;Recurrent tumor;Resistance;response biomarker;Role;Signal Pathway;Site;stem cells;stem-like cell;Testing;The Cancer Genome Atlas;Toxic effect;Transcription Coactivator;transcription factor;transcriptional reprogramming;Translating;Transplantation;tumor;tumor behavior;tumor growth;United States;Verteporfin;whole genome;Work;Xenograft Model

PROJECT_TITLE: Exploiting cell fate transition to overcome radiation resistance in glioblastoma

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health

ORG_CITY: ALACHUA

ORG_NAME: FOUNDATION FOR APPLIED MOLECULAR EVOLUTN

ORG_STATE: FL

PHR: Basic Research to Diagnostics and Surveillance in Lower Resource Environments Foundation for Applied Molecular Evolution  Steven A. Benner NARRATIVE  The recent disappointing response of the CDC to the emergency created by the "Wuhan coronavirus" (2019- nCoV) reflects the fact that the CDC is not supported by basic science related to nucleic acid chemistry, and that the CDC is constructively unaware of what science is presently available to them to meet their needs. Specifically, had the CDC used two new technologies (self-avoiding molecular recognition systems, SAMRS, and artificially expanded genetic information systems, AEGIS) in their assays, the CDC would (at the time of this writing) be distributing robust kits to detect coronavirus, and an as yet unknown number of unnecessary deaths would have been spared. This project will provide the basic science research needed to support AEGIS and SAMRS, as well as to support their general use across many applications, to speed and lower the cost of regulatory approval of diagnostics kits, and to increase manufacturing robustness of multiplexed pathogen detection products. 1

PI_NAMEs: BENNER, STEVEN A (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: 2019-nCoV;Animals;Basic Science;Biological Assay;Businesses;care costs;Cessation of life;Chemistry;Clinical;Communities;Computer software;cost;COVID-19 detection;Data;deep sequencing;Democracy;Demography;design;Diagnostic;Diagnostic Reagent Kits;Diagnostics Research;Disease;DNA;Dropout;Drops;economic impact;Emergency Situation;emerging pathogen;Enzymatic Biochemistry;Enzymes;Epidemic;Experimental Designs;experimental study;Failure;flexibility;Foundations;Future;genetic information;Guidelines;Human;improved;Information Systems;innovation;Knowledge;Learning;Malaise;manufacture;Manufacturer;Medicare;meetings;melting;Mission;Molecular Diagnosis;Molecular Evolution;molecular recognition;National Institute of Allergy and Infectious Disease;new technology;Nucleic Acids;Oral;pandemic disease;Paper;pathogen;Pathogen detection;Patients;Physicians;prevent;Process;Rectum;Regulation;relative cost;Reproducibility;Research;Research Personnel;Resistance;Resource-limited setting;Resources;response;restraint;RNA;Sampling;Science;Specific qualifier value;Speed;statistics;Symptoms;System;Temperature;Testing;Thermodynamics;Time;Travel;Vagina;Writing

PROJECT_TITLE: Basic Research for Diagnostics and Surveillance in Lower Resource Environments

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention;Primary Health Care;Social Determinants of Health

PHR: PROJECT NARRATIVE There is an urgent need to develop meaningful quality measures for Attention-Deficit/Hyperactivity Disorder (ADHD) treatment by pediatric primary care providers, as a prerequisite for improving health outcomes for children with this highly prevalent condition. This project will leverage recent advances in machine learning methods and engage key stakeholders to develop robust quality measures for ADHD treatment, and to prepare for quality improvement interventions. The completion of this project will strengthen collaborations between stakeholders to continuously improve evidence-based practices in primary care settings and mitigate health disparities for individuals with ADHD and other mental and behavioral health conditions.

PI_NAMEs: BANNETT, YAIR  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Academy;Acceleration;acceptability and feasibility;Adoption;Affect;aged;Algorithms;American;Area;Attention deficit hyperactivity disorder;Behavior Disorders;Behavior Therapy;behavioral health;care delivery;care providers;career;Caring;Characteristics;Child;Child Care;Child Health;Child health care;Child Mental Health;Childhood;Classification;Clinical;clinical care;Clinical Practice Guideline;Code;Collaborations;Communities;Consolidated Framework for Implementation Research;Consumption;cost;Data;design;Development;developmental disease;Diagnosis;Diagnostic;Disparity;disparity reduction;Electronic Health Record;electronic structure;Environment;Equity;Ethnic Origin;evidence base;evidence based guidelines;Evidence based practice;experience;Family;Feedback;Funding;Future;Goals;Guidelines;Health;health care disparity;health care service organization;Health Personnel;Health Services;Health Technology;Healthcare;Healthcare Systems;Household;Hybrids;implementation science;improved;Individual;Insurance;Intervention;Interview;Language;learning engagement;Machine Learning;machine learning method;machine learning model;maltreatment;Managed Care;Manuals;Measurement;Measures;Medical;Mental disorders;Mental Health;Mentors;Methods;Modeling;Monitor;Morbidity - disease rate;multidisciplinary;National Institute of Mental Health;Natural Language Processing;Natural Language Processing pipeline;neurobehavioral disorder;new technology;novel;Outcome;overtreatment;patient population;Patient-Focused Outcomes;Patients;Pediatrics;Performance;Pharmaceutical Preparations;Physicians;Population;Positioning Attribute;Primary Care;primary care provider;primary care setting;Primary Health Care;Process;provider adherence;Publishing;Qualitative Methods;Quality Indicator;Quality of Care;Race;Recommendation;Reduce health disparities;Research;Sampling;Scientist;side effect;skills;sociodemographic disparity;Standardization;statistics;Strategic Planning;Structure;structured data;Subgroup;success;support tools;System;Techniques;Text;Time;Training;unnecessary treatment;Variant;Work

PROJECT_TITLE: Novel Quality Measures for Primary Care Management of Attention-Deficit/Hyperactivity Disorder

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Dengue virus (DENV) and Zika virus (ZIKV) are mosquito-borne pathogens that cause substantial morbidity and mortality worldwide. We have found that both viruses require the function of the cellular ER Membrane Protein Complex (EMC) for stabilization of two viral proteins necessary for replication. The goal of this project is to define the mechanisms by which the EMC supports DENV and ZIKV infection, which will lead to insights into other viruses that are known to depend on the EMC and possibly to novel strategies to treat these viruses.

PI_NAMEs: TAI, ANDREW W. (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Anti-viral Agents;arboviral disease;Biogenesis;Biology;Bypass;Cell Physiology;Cells;Cessation of life;Data;Dengue Infection;Dengue Vaccine;Dengue Virus;Dependence;Disease Outbreaks;DNA;Endoplasmic Reticulum;experience;experimental study;Flavivirus;Flavivirus Infections;Goals;Human;Hydrophobicity;Infection;insight;Integral Membrane Protein;Integration Host Factors;Maps;Medical;Membrane Proteins;Modeling;Molecular;Molecular Chaperones;Morbidity - disease rate;mortality;mosquito-borne pathogen;mutant;Mutation;Nonstructural Protein;novel;novel strategies;Organelles;Pathway interactions;Polyomavirus;protein complex;protein degradation;protein folding;Protein-Folding Disease;Proteins;Publishing;Quality Control;Research Personnel;Rest;Role;Testing;United States;Vaccines;Viral;Viral Genome;Viral Nonstructural Proteins;Viral Proteins;virology;Virus;Virus Diseases;Virus Replication;Yeasts;Yellow fever virus;zika fever;Zika Virus;Zika virus vaccine;ZIKV infection

PROJECT_TITLE: How flaviviruses hijack a host transmembrane protein chaperone to promote viral infection

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Public Health Relevance Among people living with Alzheimer’s disease (PWD)-caregiver research, most studies concentrate on the caregiver-PWD dyad which is not representative of real-life as multiple family members and non-related friends are often involved in the care of PWD. To advance the measurement of PWD-caregiver networks in research, we will use an NIH-funded Social Network methodology software (Network Canvas) in a multi-site observational study of 200 PWD-caregiver networks. Through this research, we plan to have a better understanding of how to measure PWD-caregiver networks and operationalize a network measurement approach to understand caregiver systems that will be shareable with other researchers.

PI_NAMEs: BIRKETT, MICHELLE ;LINDQUIST, LEE A (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease caregiver;Alzheimer's disease related dementia;Anxiety;Businesses;Caregiver research;Caregiver support;Caregiver well-being;Caregivers;caregiving;Caring;cohort;Communication;Communities;community partners;Computer software;Conflict (Psychology);Consent;Data;Dementia;emotional distress;Enrollment;Ethnic Origin;expectation;experience;Family Caregiver;Family member;Friends;Funding;Goals;Health system;Heterogeneity;HIV;Home;Individual;Interpersonal Relations;Interview;Lesbian Gay Bisexual Transgender Queer;Life;Lived experience;Location;Maps;Measurement;Measures;member;Methodology;Methods;novel;Observational Study;older adult;open source;Outcome Measure;Patient-Focused Outcomes;Patients;Persons;Physicians' Offices;Population Heterogeneity;primary caregiver;psychologic;public health relevance;racial diversity;recruit;Research;Research Personnel;Rural;Schools;Site;Social Network;Social support;Stress;System;Trust;United States National Institutes of Health

PROJECT_TITLE: Measuring Caregiver Networks of Older Adults with Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-A(56)R]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The (dys)regulation of telomeres, the terminal structures of linear chromosomes, is associated with immortalization, aging and tumorigenesis. This fact is best exemplified by the bone marrow failure and cancer predisposition syndrome, dyskeratosis congenita, where mutations in eleven genes, all of which encode factors required for telomere maintenance, are known to cause the disease. Approbation of the belief that telomere maintenance is an important area of investigation was provided by the 2009 Nobel Prizes in Physiology or Medicine, which were awarded for the discovery of telomeres and telomerase.

PI_NAMEs: HENDRICKSON, ERIC A (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Address;Aging;Aneuploidy;Applications Grants;Area;Award;Belief;Biology;Bone marrow failure;Bypass;C-terminal;Cancer Biology;cancer predisposition;carcinogenesis;cell age;Cell Death;Cell Line;Cell Survival;cell transformation;Cells;chromosome fusion;Chromosomes;chromothripsis;Collaborations;Data;Disease;DNA;DNA ligase III;DNA Repair;DNA-Directed DNA Polymerase;Dyskeratosis Congenita;Ensure;Event;Excision;experimental study;Frequencies;Gene Modified;Gene Mutation;Gene Targeting;Genes;Genetic;Genome;Genomic Instability;Goals;Human;Investigation;Knowledge;Laboratories;loss of function;loss of function mutation;Maintenance;Malignant Neoplasms;Mediating;Medicine;Modeling;Mus;mutant;Mutation;Nobel Prize;Nonhomologous DNA End Joining;novel;nuclease;Null Lymphocytes;Outcome;Pathologic;Pathway interactions;Physiology;Play;Poly(ADP-ribose) Polymerases;Polymerase;prevent;Process;Production;progenitor;Proliferating;Proteins;Publications;Regulation;repaired;Resolution;response;Role;senescence;single molecule;Sister Chromatid;Structure;Syndrome;System;Technology;Telomerase;telomere;Telomere Maintenance;Telomere Shortening;tumorigenesis;Ultrafine

PROJECT_TITLE: POLQ- and CtIP-regulated telomere fusions and translocations are involved in early events in carcinogenesis

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Clinical Research;Genetic Testing;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: Boston

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: NARRATIVE The goal of this proposal is to develop a novel, noninvasive, and sensitive bladder cancer screening test using cells found in voided urine samples that are imaged with ultra-high-resolution atomic force microscopy. The proposed method will improve the current standard-of-care cytological evaluation of voided urine test (VUC) to detect bladder cancer with higher accuracy, and further help to identify the grade of cancer. We anticipate this innovative technology will remarkably improve patient participation for screening and follow-up on bladder cancer, and confidently nominate patients for the more invasive and expensive detection using cystoscopies.

PI_NAMEs: DEMIDENKO, EUGENE ;SOKOLOV, IGOR  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Adhesions;algorithmic methodologies;Atomic Force Microscopy;Benign;Biochemical Genetics;Biochemical Markers;Biological Markers;Biopsy;Bladder;Body Fluids;Cancer Detection;cancer diagnosis;Cancer Diagnostics;Cancer Patient;Cell Extracts;cell fixation;cell fixing;Cell surface;Cells;cellular imaging;Cervical Smears;Cessation of life;Characteristics;Clinical;clinical implementation;cohort;Collaborations;Collecting Cell;Collection;Colorectal Cancer;Confusion;Control Groups;cost;Cystoscopy;Cytology;Data;Detection;Diagnosis;diagnosis standard;digital;Disease;Dysuria;Early Diagnosis;Epithelial Cells;Evaluation;Excision;Feces;flexibility;follow-up;genetic analysis;Goals;Hematuria;high risk;Hospitals;Image;imaging modality;improved;Individual;Infection;innovative technologies;Judgment;Machine Learning;machine learning method;Malignant neoplasm of cervix uteri;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Mechanics;Medical Oncology;Membrane;method development;Methods;microscopic imaging;Modality;Modeling;Monitor;nanoscale;Nature;novel;Optics;Pain;Pathology;Patient Compliance;Patient Monitoring;Patient Participation;Patients;physical property;Preparation;Procedures;programs;Property;Protocols documentation;Random Allocation;Recording of previous events;Recurrence;Reproducibility;Research;Resources;Risk;ROC Curve;sample fixation;Sampling;Sampling Errors;screening;Screening for cancer;screening participation;Sputum;standard of care;Statistical Data Interpretation;Statistical Methods;Subgroup;Surface;Surface Properties;Survivors;Technology;Testing;Time;Tissues;tumor;ultra high resolution;Urine;Urologic Cancer;Urology;Urothelium;viscoelasticity;Visual;Work

PROJECT_TITLE: Noninvasive bladder cancer diagnostics via machine learning analysis of nanoscale surface images of epithelial cells extracted from voided urine samples

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Fort Lauderdale-Davie

ORG_NAME: NOVA SOUTHEASTERN UNIVERSITY

PHR: Narrative: The purpose of proposed study is to understand the molecular mechanism underlying the retarded regeneration of connective tissue and alveolar bone in periodontitis (Gum Disease) by focusing on death induced in mesenchymal stem cells (baby cells that can differentiate into bone, gum and many other cell types). Our preliminary data indicate that the pathogenic bacteria for periodontitis, P. gingivalis (Pg), but not other periodontal bacteria, can cause atypical cell death of periodontal stem cells, but not epithelial cells, which not only kills the periodontal stem cells, but also induce inflammation. This study is expected to lead to the development of a therapeutic strategy that prevents such a unique stem cell death and, thus, alleviating inflammation and inducing tissue regeneration in periodontitis.

PI_NAMEs: HEIDARI, ALIREZA  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Address;Affect;Affinity;alveolar bone;Apoptosis;Applications Grants;Arginine deiminase;Autoimmune Diseases;Bacteria;Binding;bone;Cell Death;Cell Death Induction;Cell Line;Cell Nucleus;cell type;Cells;Cessation of life;Chromatin;Confocal Microscopy;Connective Tissue;cytokine;Cytoplasm;Data;Development;Disease;DNA;dysbiosis;Enzymes;Epithelium;Eukaryota;Exposure to;extracellular;Fibroblasts;Genes;Gingiva;Goals;Histone H3;Histones;HMGB1 gene;Human;Inflammation;Inflammatory;inflammatory bone resorption;inhibitor;Interferometry;Interleukin-1 beta;Knock-out;Lesion;Ligands;Macrophage;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mesenchymal Stem Cells;microbiome;Molecular;Monitor;monocyte;Natural regeneration;neutrophil;novel strategies;opportunistic pathogen;oral pathogen;osteoblast differentiation;Osteoblasts;pathogenic bacteria;Pathogenicity;Pathologic;Pathway interactions;Periodontitis;Periodontium;Porphyromonas gingivalis;prevent;Prevention strategy;Production;promoter;Property;receptor;regeneration potential;response;Role;Sepsis;Site;stem cells;theories;Therapeutic;Time;tissue regeneration;Tissues;TLR2 gene;TLR4 gene;transcriptome sequencing;Vesicle

PROJECT_TITLE: P. gingivalis Effect on Periodontal Mesenchymal Stem Cell


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Kidney Disease;Pediatric;Polycystic Kidney Disease;Rare Diseases

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

PHR: Project Narrative Extracellular fluid flows act signals, either by providing mechanical force or directing chemicals across cell surfaces, however, few proteins that sense and transduce fluid flows signals have been identified. The purpose of this research is to use the zebrafish left-right patterning system to characterize novel proteins that sense and transduce fluid flows. Through this work we will gain insight into diseases caused by aberrant fluid flows like polycystic kidney disease, heterotaxy, and congenital heart defects.

PI_NAMEs: FISHER, KATHERINE H (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Brain;Cell Communication;Cell surface;Cells;Chemicals;Cilia;cilium motility;Communication;Complex;congenital heart abnormality;Congenital Heart Defects;Critical Pathways;Data;Defect;Development;developmental disease;Disease;Dissection;Embryo;Esthesia;Event;experimental study;Extracellular Fluid;fluid flow;Generations;Genes;Genetic;Genetic Screening;Hydrocephalus;insight;Integral Membrane Protein;Kidney;Kidney Diseases;Left;Ligands;Link;Lung;mechanical force;Mechanical Stimulation;Membrane;Membrane Proteins;Motility;mutant;Mutation;nephrogenesis;novel;Output;Pathway interactions;Pattern;Polycystic Kidney Diseases;Primary Ciliary Dyskinesias;Proteins;Reporter;Reporting;Repression;Research;reverse genetics;sensor;Sensory;Side;Signal Pathway;Signal Transduction;Situs Inversus;System;Testing;tool;Work;Zebrafish

PROJECT_TITLE: Genetic dissection of fluid flow signaling in Left-Right patterning of zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;HIV/AIDS;Infectious Diseases;Patient Safety;Prevention;Prostate Cancer;Urologic Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE The objective of this study is to improve the management and outcomes for people living with HIV (PWH) diagnosed with clinically localized prostate cancer. Towards this end, we will create a novel microsimulation model of prostate cancer natural history and treatment outcomes in PWH to perform comparative effectiveness analyses tailored to this population. Our results will identify the optimal prostate cancer management for PWH to reduce treatment toxicities, maximize survival and quality of life.

PI_NAMEs: CHIAO, ELIZABETH Y.;DESHMUKH, ASHISH A.;SIGEL, KEITH MAGNUS (contact)

PROGRAM_OFFICER_NAME: LIDDELL HUPPI, REBECCA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adverse event;age effect;Aging;aging population;American Society of Clinical Oncology;antiretroviral therapy;Calibration;Cancer Control;cancer diagnosis;cancer therapy;carcinogenesis;Cause of Death;CD4 Lymphocyte Count;chemotherapy;Clinical;clinical decision-making;Clinical Management;Clinical Trials;cohort;Cohort Studies;common treatment;comorbidity;comparative;comparative effectiveness analysis;Data;data integration;Decision Aid;Decision Making;Diagnosis;Disease;Disease Outcome;Disease Progression;disorder risk;Disseminated Malignant Neoplasm;Event;experience;functional status;Goals;Harm Reduction;Health;Health system;high risk;HIV;HIV diagnosis;HIV Infections;hormone therapy;Immune System Diseases;improved;Life Expectancy;Malignant neoplasm of prostate;Malignant Neoplasms;Medicare;men;Modality;Modeling;models and simulation;Morbidity - disease rate;mortality;mortality risk;Natural History;neoplasm registry;novel;Outcome;Pathway interactions;Persons;Population;Premature aging syndrome;Process;Prostate;prostate cancer model;prostate cancer progression;prostate cancer risk;prostate cancer survivors;Prostate Cancer therapy;Prostatectomy;Quality of life;Quality of Life Assessment;Radiation;Radiation therapy;Recommendation;Recording of previous events;Regional Cancer;Risk;Role;Second Primary Cancers;Selection for Treatments;simulation;Source;Stage at Diagnosis;Subgroup;Surgical complication;surgical risk;Texas;Therapeutic;therapy outcome;Toxic effect;treatment disparity;treatment optimization;Treatment outcome;Treatment Protocols;treatment risk;Treatment-related toxicity;tumor;tumor progression;Uncertainty;Veterans

PROJECT_TITLE: Optimizing Treatment of Prostate Cancer in Men living with HIV


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE Human papillomavirus (HPV), a vaccine preventable disease, is the most common sexually transmitted disease impacting young men and women. This study focuses on Korean Americans, a population at high-risk of HPV- caused cancers but who have low HPV vaccination coverage rates. This study proposes to refine a novel theory- guided, culturally appropriate storytelling HPV intervention that leverages artificial intelligence chatbot technology to facilitate timely, effective, and sustained motivation to increase the HPV vaccine uptakes of Korean American men and women aged 18-26 years old.

PI_NAMEs: KIM, MINJIN  (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: acceptability and feasibility;aged;Area;Artificial Intelligence;Asian;Asian population;Asian Women;Attitude;Award;Behavior;Black Populations;Cancer Etiology;cancer prevention;cancer statistics;career;chatbot;Clinical Management;Clinical Trials;Collaborations;college;Communication;Communities;Data;Data Aggregation;Dedications;design;digital;Disease;disorder prevention;Disparity;Documentation;effectiveness outcome;effectiveness testing;efficacy evaluation;Ethnic Origin;experience;Feasibility Studies;Future;Genitalia;Goals;Health;Health behavior and outcomes;health communication;health data;health difference;Health Disparities Research;health disparity;health equity;health equity promotion;Health Promotion;Hispanic Populations;HPV vaccine acceptance;HPV-High Risk;Human;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation outcomes;improved;Incidence;Individual;Infection;innovation;insight;International;Intervention;Intervention Studies;K-Series Research Career Programs;Knowledge;Korean American;Koreans;Leadership;longitudinal analysis;malignant mouth neoplasm;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant neoplasm of penis;Malignant neoplasm of vulva;Malignant Neoplasms;Malignant Vaginal Neoplasm;Manuals;Measures;Mediating;Mediation;Medical;men;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Mexican Americans;mHealth;Minority;Minority Groups;Mission;Motivation;multiphase optimization strategy;Not Hispanic or Latino;novel;Online Systems;operation;optimism;Outcome;Participant;Persons;Photography;Population;post intervention;post-doctoral training;pragmatic trial;pre-doctoral;Preparation;Prevalence;prevent;Prevention program;Preventive;primary outcome;Procedures;programs;Randomized;Randomized, Controlled Trials;recruit;Reduce health disparities;Research;Research Design;Research Methodology;Research Training;Resources;retention rate;Risk;satisfaction;Scientist;secondary outcome;Sexually Transmitted Diseases;Site;skills;Statistical Methods;Structure;Subgroup;System;Technology;Testing;theories;therapy design;Throat Cancer;Time;Training;Transcultural Nursing;United States National Institutes of Health;usability;Vaccination;vaccine acceptance;Vaccines;Voice;White Women;Woman;young adult;young man;young woman

PROJECT_TITLE: Let’s K-Talk: A Storytelling Intervention Leveraging Chatbot Technology to Prevent HPV and HPV Associated Cancers for Ethnic Koreans Living in the U.S.

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(82)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative The goal of the Rutgers Training Program in Addiction Research is to provide a diverse group of trainees with an appreciation of modern interdisciplinary substance use disorder research, which could lay the groundwork for the development of novel and innovative addiction treatments. The program encompasses a diverse array of basic science approaches as well as human genetics and imaging studies. The didactic aspects of the program take full advantage of the broad expertise of our faculty mentors while continually emphasizing research ethics as well as training in scientific rigor and reproducibility.

PI_NAMEs: PIERCE, ROBERT CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: addiction;programs;Research;Training

PROJECT_TITLE: Rutgers Training in Addiction Research Program