NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Social Determinants of Health

PROJECT_TERMS: Achievement;Advisory Committees;anti-cancer research;Area;Awareness;California;Cancer Biology;Cancer Center;cancer education;cancer health disparity;career;career development;Clinical;cohort;Collaborations;Communication;Communities;community clinic;community engagement;community organizations;Coupled;Dedications;Degree program;Development;Doctor of Philosophy;doctoral student;Education;education research;Educational Activities;effectiveness evaluation;Ensure;Environment;Ethnic Population;Evaluation;experience;Exposure to;Faculty;Fellowship;Financial Support;follow-up;Funding;Future;Goals;graduate student;Grant;Health;Health Disparities Research;health equity;Health equity research;Human Resources;improved;Individual;interest;Joints;Laboratory Research;Leadership;Malignant Neoplasms;Manuscripts;medical schools;Medical Students;Mentors;Mentorship;Modeling;Molecular Chaperones;multidisciplinary;Neighborhood Health Center;operation;Participant;peer;peer coaching;Physicians;pre-clinical;Preparation;programs;Provider;public health research;racial population;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resource Sharing;Scholars Program;Schools;Science;Scientist;social determinants;student participation;Students;success;summer research;Time;Training;Travel;Trinidad;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Work

PROJECT_TITLE: Research Education Core


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PI_NAMEs: NODORA, JESSE  (contact)

PROJECT_TERMS: Address;Adopted;Advanced Malignant Neoplasm;agricultural community;Alaska Native population;American Indian Population;anti-cancer research;Area;Asian population;Black Populations;California;cancer care;cancer education;cancer health disparity;Cancer health equity;Caring;Catchment Area;Collaborations;collaborative approach;Communities;community advisory board;community building;community collaboration;community engaged research;community engagement;Community Health Systems;community organizations;community partnership;County;Data;design;Development;Diagnosis;Diffusion;Disparity;Early Diagnosis;Education;Education and Outreach;education research;Educational workshop;Ensure;ethnic diversity;Ethnic Population;Evaluation;Evidence based practice;experience;Fostering;Geographic Locations;Goals;graduate student;health equity;Health equity research;Hispanic Populations;implementation science;improved;Individual;Infusion procedures;innovation;Institution;Intervention;Investments;Leadership;Linguistics;Malignant Neoplasms;Medical Students;medically underserved;Methodology;Mexico;Minority;Mission;Modeling;multidisciplinary;NCI-Designated Cancer Center;Needs Assessment;Neighborhood Health Center;Not Hispanic or Latino;outreach;Pacific Islander;Pathway interactions;Patients;Population;Positioning Attribute;Prevention;programs;Race;racial population;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resource Sharing;Resources;Risk Factors;Rural;screening;Screening for cancer;student participation;survivorship;Teacher Professional Development;Training;undergraduate student;underserved community;Underserved Population;Voice;web platform;Work

PROJECT_TITLE: Outreach Core


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: Columbus

ORG_DEPT: PSYCHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: There is increasing concern that social media use may be impacting mental health in adolescents. The goal of this proposal is to determine if using social media passively is related to mental health as well as characterize physiological pathways (parasympathetic nervous system and alterations in expression of genes regulated by the immune system) that influence risk for poor mental and physical health. Additionally, we will examine how self-reported stressors and geospatial exposures to stressful environments (i.e. streets with high levels of violent crime) impact frequency of passive social media use and the degree to which passive social media use as stress coping strategy alters emotional and physiological responses to stressors.

PI_NAMEs: LEE, DAVID ;WAY, BALDWIN M (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Adolescent;adolescent mental health;Adult;Affect;Affective;Age;Area;Behavior;Biological;biological adaptation to stress;Biology;Black race;Blood;Blood Cells;C-reactive protein;Cellular Phone;Charge;Collection;complement C2a;coping;Coping Skills;Crime;Cross-Sectional Studies;Data;depressive symptoms;Ecological momentary assessment;Emotional;Environment;experience;Exposure to;Female;Frequencies;Gender;Gene Expression;Genes;girls;Goals;heart rate variability;Hormones;Hydrocortisone;Immune;Immune system;Individual Differences;Inflammation;Inflammatory;inflammatory marker;Interferons;Leukocytes;Life;Link;Location;Longitudinal Studies;male;Measurement;Measures;media use;Mental Depression;Mental Health;model building;Modeling;Monitor;negative affect;Neighborhoods;novel;Outcome;Parasympathetic Nervous System;Participant;Pathway interactions;Patient Self-Report;Personal Satisfaction;Persons;Phase;physical conditioning;Physiological;Police;Predictive Factor;Probability;Process;psychobiology;psychologic;Published Comment;Race;racial diversity;Records;recruit;Reporting;Research;response;Risk;Risk Factors;Role;Safety;Sampling;self esteem;Signal Pathway;Signaling Protein;social;social influence;social media;social stress;Stress;Stress and Coping;Stressful Event;stressor;Surveys;System;Teenagers;Telephone;Testing;Time;transcription factor;violent crime;Viral;Work;wristband;Youth

PROJECT_TITLE: Passive social media use, coping, and momentary stress in geospatial context: longitudinal effects on mental health and intermediate biological pathways in a racially diverse sample of adolescents


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Genetics;Heart Disease;Human Genome;Obesity;Physical Activity;Precision Medicine;Prevention;Sleep Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Little is known about the impact of activity, sleep patterns, and genetic background on cardiovascular risk. We propose to use Fitbit and genomic data from the All of Us Research Program to examine the separate and aggregate associations between physical activity and sleep behaviors and genetic background on the incidence of cardiovascular risk factors.

PI_NAMEs: BRITTAIN, EVAN L (contact);RUDERFER, DOUGLAS

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Address;All of Us Research Program;Atrial Fibrillation;Behavior;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;care seeking;Cessation of life;Chronic Disease;Clinical;Clinical Data;cohort;Collection;Cox Proportional Hazards Models;Data;Data Sources;Devices;Diabetes Mellitus;Disease;disorder risk;Dyslipidemias;Electronic Health Record;Environment;fitbit;Floor;Genetic;Genetic Predisposition to Disease;Genetic Risk;Genome;genome sequencing;genomic data;Genomics;Health;Heart failure;high risk;human disease;Hypertension;improved;improvement on sleep;Incidence;Individual;Knowledge;Major Depressive Disorder;Measures;Mental Depression;Modeling;modifiable behavior;Monitor;Morbidity - disease rate;mortality;Myocardial Infarction;Nature;Obesity;Onset of illness;Outcome;Patient-Focused Outcomes;Peripheral arterial disease;Persons;phenome;Phenotype;Physical activity;polygenic risk score;Population;Qualifying;Recommendation;Research;Research Personnel;Risk;Risk Factors;Role;Sampling;secondary analysis;Severity of illness;Sleep;sleep behavior;Sleep Disorders;sleep pattern;Source;Stroke;Testing;Time;wearable data;wearable device;whole genome;Work

PROJECT_TITLE: Impact of Physical Activity, Sleep, and Genetic Background on Cardiovascular Risk in the All of Us Program


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Temporal lobe epilepsy (TLE) is a debilitating disorder characterized by spontaneous and recurring seizures and persistent memory and emotional impairments that are both treatment resistant and dissociable from seizures themselves. There is strong evidence that these comorbidities are driven by circuit deficits along the dorsoventral axis of the entorhinal-hippocampal circuit, thus necessitating characterization of epilepsy- induced circuit changes at both functional and molecular levels. In this proposal, I will use an established mouse model of TLE to determine how epilepsy drives functional and molecular changes in entorhinal-hippocampal circuits implicated in spatial memory and emotional deficits, providing new insight for development of targeted therapeutics.

PI_NAMEs: SOLER, IVAN  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Address;Affinity Chromatography;Anhedonia;Animals;Anxiety;anxiety-like behavior;Automobile Driving;Award;Behavior;Behavioral;Biological Assay;Brain;Calcium;career;cell type;Chronic;clinical phenotype;Code;Cognitive deficits;combinatorial;comorbidity;Data;Data Analyses;dentate gyrus;Development;Disease;Dorsal;emotion regulation;Emotional;emotional behavior;Emotions;entorhinal cortex;Epilepsy;experimental study;Functional disorder;Future;Gene Expression;Genetic;Goals;hippocampal pyramidal neuron;Hippocampus;Image;Impairment;in vivo calcium imaging;in vivo imaging;insight;Intervention;large-scale imaging data;Learning;Linear Models;Link;Location;Medial;Mediating;Memory;Memory impairment;Modeling;Molecular;molecular marker;Molecular Profiling;mouse model;Mus;neural;neural circuit;Neurons;novel;Patients;Pharmacological Treatment;Phase;Pilocarpine;Population;Postdoctoral Fellow;programs;psychiatric symptom;Quality of life;Recurrence;Research;Research Personnel;Resistance;Ribosomes;Running;Scientist;Seizures;Signal Transduction;Site;skills;spatial memory;stellate cell;Stress;targeted treatment;Technical Expertise;Techniques;Temporal Lobe;Temporal Lobe Epilepsy;Testing;Time;timeline;tool;Training;transcriptome sequencing;transcriptomics;Translating;Viral;Work

PROJECT_TITLE: Progression of Entorhinal-hippocampal Spatial and Emotional Processing Deficits in a Mouse Model of Temporal Lobe Epilepsy

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PUBLIC HEALTH RELEVANCE STATEMENT / PROJECT NARRATIVE Health research in low- and middle-income countries (LMICs) is often conducted in collaboration with investigators and institutions in high-income countries with the rationale that this helps circumvent many of the structural and economic limitations faced by LMIC-based researchers and promotes local research priorities at a global scale. However, there is growing attention to the fact that international research partnerships may often inadvertently perpetuate academic and scientific asymmetries between research partners which ultimately risks suboptimal scientific and partnership outcomes. Here we use experienced HIV-focused research partnerships between Uganda and the United States to comprehensively describe best practices and barriers to equitable research collaboration and pilot a pragmatic equity planning tool to guide international research partnerships toward equity-focused outputs.

PI_NAMEs: MODLIN, CHELSEA  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: acceptability and feasibility;Achievement;Address;Area;Assessment tool;Attention;Award;burden of illness;Caring;Case Series;Categories;Collaborations;Communication;Communities;Competence;Consensus;Country;Dependence;design;Development;Economics;efficacy evaluation;Ensure;Epidemic;Equity;Ethics;ethnographic method;Evaluation;experience;Feedback;Focus Groups;Fogarty International Center;follow-up;Foundations;Funding;Geographic Locations;global health;Goals;Guidelines;Health;Health Promotion;Health Sciences;HIV;improved;Income;Inequality;Inequity;Infrastructure;insight;Institution;International;international partnership;Interview;Knowledge;Lead;Leadership;Link;low and middle-income countries;Maintenance;Malignant Neoplasms;Mentorship;Methods;Mission;Modeling;multidisciplinary;Outcome;Output;Participant;participant observation;Physicians;Population;Positioning Attribute;Process;process improvement;programs;prospective;public health relevance;Qualitative Evaluations;Qualitative Methods;Recommendation;Reporting;Research;Research Ethics;Research Personnel;Research Priority;Resources;response;Risk;scale up;social;Structure;Surveys;System;theories;tool;Training;Translations;Trust;Uganda;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Designing and Implementing an Equity Planning Tool for International Research Partnerships

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-P(55)R]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative  Despite substantial investment in treatment, prevention, and recovery, the United States continues to experience historically high rates of fatal overdoses, many of which involve opioids. Naloxone, an opioid antagonist, is a highly effective overdose reversal mechanism that can be easily used by laypersons – but it remains remarkably underutilized. This study will test how best to connect a large, existing CPR citizen responder network with opioid education and naloxone distribution programs, with the long-term goal of supporting a national-scale assessment of whether this approach can reduce the prevalence of fatal opioid- involved overdoses.

PI_NAMEs: AGLEY, JON  (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;Agreement;American;arm;Articulation;Awareness;Binding;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Communities;cost;design;Dose;Education;effectiveness evaluation;Emergency response;Epidemic;experience;Fatality rate;feasibility testing;feasibility trial;first responder;Focus Groups;follow-up;Fostering;Goals;illicit opioid;Incentives;Incidence;Individual;informant;Infrastructure;Interview;Investments;Knowledge;Law Enforcement;Life;Literature;matriculation;Medical;Misinformation;mobile application;multimodality;Naloxone;naloxone carriage;naloxone dispensing;Notification;Opioid;Opioid Antagonist;opioid overdose;Outcome;Overdose;overdose death;overdose education;Overdose reversal;Persons;Pharmaceutical Preparations;Positioning Attribute;Prevalence;prevent;Prevention;Procedures;programs;Radial;Randomized;Randomized, Controlled Trials;Recovery;recruit;Reporting;Resources;response;Rest;Risk Factors;Sampling;social stigma;System;Testing;Time;tool;Training;trial design;Unconscious State;United States;uptake;willingness

PROJECT_TITLE: Feasibility of Leveraging the National PulsePoint CPR Responder Network to Facilitate Overdose Education and Naloxone Distribution

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ATHENS

ORG_NAME: OHIO UNIVERSITY ATHENS

PHR: PROJECT NARRATIVE The goal of this study is to improve care coordination for children with vascular anomalies, especially those in rural areas. Pediatricians often lack the knowledge and resources needed to care for patients with vascular anomalies and struggle to coordinate care with specialists. High-quality care coordination is essential for patients managing rare diseases and can help reduce the risk of emergency room visits, hospitalizations, and readmissions, particularly for patients in rural communities who live far from specialized medical centers.

PI_NAMEs: HUGHES, ALLYSON  (contact)

PROGRAM_OFFICER_NAME: EDEN, AIMEE

PROJECT_TITLE: Primary Care Needs for Patients with Vascular Anomalies: Improving Continuity of Care and Care Coordination in Rare Diseases

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;Physical Injury - Accidents and Adverse Effects

ORG_CITY: LOS ANGELES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The proposed research is relevant to public health because the development and validation of a data-driven lay first responder program aims to fill a critical deficit in prehospital care and decrease deaths and disability among injured patients in Cameroon. If found to be feasible and effective, this approach would shift clinical practice patterns in this context. The research is relevant to the NIH’s mission because it seeks to lengthen the lives of trauma patients.

PI_NAMEs: CHRISTIE, SABRINAH ARIANE (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Affect;Africa South of the Sahara;Blood Transfusion;Cameroon;care systems;Caring;Cessation of life;Clinical;Clinical Data;Clinical Practice Patterns;Code;cohort;Complication;Country;Data;data registry;design;Development;disability;Educational Curriculum;Effectiveness;effectiveness evaluation;Environment;Evaluation;Exposure to;Feedback;First Aid;first responder;Focus Groups;Genetic Transcription;Goals;Hospital Mortality;Hospitalization;Hospitals;Hour;implementation protocol;implementation science;Improve Access;improved;Infrastructure;injured;Injury;injury-related death;Interruption;Interview;knowledge base;Laboratories;Life;low and middle-income countries;Medical;Medical Records;Methods;Mission;Morbidity - disease rate;mortality;operation;Outcome;Patient Admission;Patients;Pattern;Patterns of Care;Physiological;Population;post implementation;Pre-hospitalization care;prevent;programs;prospective;Public Health;recruit;Registries;Reproducibility;Research;Research Assistant;Research Infrastructure;Rural;Series;Severities;Structure;Surveys;Techniques;Time;Training;Training Programs;Translations;Trauma;trauma care;Trauma patient;trend;United States National Institutes of Health;Validation

PROJECT_TITLE: Implementation of a data-driven pre-hospital lay first responder program in Cameroon


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Skin Cancer

ORG_CITY: La Jolla

ORG_NAME: NANOMETICS, LLC

PHR: PROJECT NARRATIVE Non-melanoma skin cancers are a growing public health challenge that cost the United States (U.S.) healthcare system more than $1 billion in treatment costs annually. Actinic Keratoses (AK) are ultraviolet light induced premalignant skin lesions that are precursors to cutaneous squamous cell carcinoma (CSCC). CSCC is the second most common type of cancer, is associated with significant morbidity, and results in more deaths than from melanoma in the U.S. each year. This Direct Phase II SBIR proposal builds upon two successfully completed clinical trials and aims to complete a Phase 2, randomized, double-blind, 4-arm, multicenter study to demonstrate the efficacy and safety of topical dosage formulations of Calcipotriol (CPO) plus 5-Fluorouracil (5- FU) for the treatment of AK.

PI_NAMEs: ISAACMAN, STEVEN  (contact)

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: Academy;Actinic keratosis;adaptive immune response;Address;Aftercare;American;Area;arm;beneficiary;Biological Sciences;Calcipotriene;cancer type;CD4 Positive T Lymphocytes;Cessation of life;Clinical;Clinical Research;Clinical Trials;Cold Therapy;commercial application;cost;Cream;Curettage procedure;Data;Death Rate;Dermatologist;Dermatology;design;Development;Diagnosis;Diffuse;dosage;Dose;Double-Blind Method;Drug Prescriptions;Effectiveness;Effector Cell;efficacy evaluation;Exhibits;Face;Fluorouracil;Formulation;Goals;Health Insurance;Healthcare Systems;Immune response;Immune system;Immunity;Immunocompetent;improved;Incentives;Individual;Insurance;Insurance Carriers;interest;Keratosis;Knowledge;Legal patent;Lesion;Malignant Neoplasms;Market Research;Marketing;Melanoma;Metabolic Clearance Rate;Mission;Morbidity - disease rate;Multicenter Studies;National Cancer Institute;National Comprehensive Cancer Network;Neck;open label;Outcome;Patients;Pharmaceutical Preparations;Pharmacy facility;Phase;phase 3 study;Phase II Clinical Trials;Physicians;Placebo Control;Placebos;premalignant;prevent;Price;price lists;primary endpoint;Probability;Public Health;Publishing;Randomized;randomized trial;Reaction;Recommendation;recruit;Regimen;Regulation;Reporting;Research;Research Design;Risk;Risk Reduction;Safety;Sales;Scalp structure;secondary endpoint;side effect;Skin;Skin Carcinoma;skin lesion;skin squamous cell carcinoma;Small Business Innovation Research Grant;technological innovation;Technology;Treatment Cost;treatment duration;United States;United States Food and Drug Administration;UV induced;willingness

PROJECT_TITLE: A Phase 2, randomized, double-blind, 4-arm, multicenter study to demonstrate the efficacy and safety of topical dosage formulations of a prescription drug product for actinic keratosis


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Nutrition

ORG_CITY: WOODLANDS

ORG_NAME: MERIDIAN BIOTECH, LLC

ORG_STATE: TX

PHR: Project Narrative A key problem in Zebrafish (Danio rerio) husbandry science and industry is that a high-quality standardized diet, including optimized physical properties and feed management strategies, has not been developed for this important vertebrate animal model. Our solution for the industry, driven by a synergistic collaboration between Meridian Biotech and the laboratory of Dr. Stephen Watts at the University of Alabama at Birmingham, is to develop optimized ingredient profiles (based on bacterial-based single cell protein source) for an open formulation standard reference diet for larval, juvenile and adult Zebrafish, that will achieve a desired level of control and whereby use of Zebrafish as a modern and effective biomedical animal model is substantially improved and standardized. Given the utility of the Zebrafish as an animal model for human health, and coupled with the concomitant investment of research dollars, it is imperative that we develop open, high quality standard reference diets to add to the confidence, reproducibility, and exchange of results derived from this important animal model.

PI_NAMEs: CORACE, DONALD  (contact);WATTS, STEPHEN ANDREW

PROGRAM_OFFICER_NAME: VONKOLLMAR, DESIREE

PROJECT_TERMS: Academia;Address;Adolescent;Adoption;Adult;Affect;Alabama;Amino Acids;Animal Model;Applied Research;Aquaculture;Biomass;Biomedical Research;Biotechnology;Businesses;Canada;Caseins;cohort;Collaborations;commercialization;Coupled;Data;Development;Diet;Dietary Proteins;Disease;Dryness;Farm;Fatty acid glycerol esters;Fatty Acids;feeding;Fishes;Formulation;Fortification;Gel;Genetic;Goals;Growth;Health;Human;Immunocompetence;improved;Industry;Intake;Investments;Laboratories;lipid metabolism;manufacturing capabilities;manufacturing scale-up;Marketing;Meridians;microbial;microbiome;Modeling;Modernization;Mus;Nutrient;Nutritional;offspring;Organism;Outcome;Penetration;pharmacologic;Phase;Phenotype;physical property;Physiological Processes;Production;programs;Progress Reports;Proteins;Reference Standards;Reproducibility;reproductive;reproductive success;Research;Science;Shrimp;single cell proteins;Small Business Innovation Research Grant;Source;Standardization;Technology;Testing;Toxicology;transcriptome sequencing;trial design;United States National Institutes of Health;Universities;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Development and Production of Standardized Reference Diets for Zebrafish Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(10)B]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: Acute lung injury, or acute respiratory distress syndrome (ARDS) is the final common pathway of a variety of direct and indirect insults to the lungs. Lower respiratory tract bacterial infections and pneumonia contribute to prolonged respiratory failure and increase morbidity and mortality in patients with acute lung injury, or acute respiratory distress syndrome (ARDS). The broad, long term objective is to identify key factors that promote host protection against pathogen-triggered lung injury.

PI_NAMEs: LEE, JANET SOJUNG (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Ablation;Acute Lung Injury;Acute Respiratory Distress Syndrome;Admission activity;Alpha Granule;Alveolar;anti-microbial drug;Bacteria;Bacterial Infections;Bacterial Pneumonia;Biology;Blood capillaries;Blood Platelets;Calibration;Cathepsins;Cell Survival;Cells;Clinical;conditional knockout;Critical Care;cytokine;Data;Elastases;Environment;Epithelial Cells;Exhibits;extracellular;Extracellular Matrix;fungus;Goals;Host Defense;Human;improved;in vivo;indexing;Infection;Inflammation;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;inhibitor;Injury;Integration Host Factors;intravital microscopy;Leukocyte Elastase;Lower respiratory tract structure;Lung;Lung infections;lung injury;Managed Care;Mediating;Metalloproteases;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Mutation;N-terminal;neutralizing antibody;neutrophil;Neutrophil Activation;Outcome;pathogen;Pathogenicity;Pathway interactions;Patients;Peptide Hydrolases;Platelet Activation;Positioning Attribute;Predisposition;Production;promote resilience;Property;Protein Secretion;Proteolysis;Proteolytic Processing;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Publishing;Pulmonary Inflammation;rational design;repaired;Reporter;respiratory;Respiratory Failure;Respiratory Tract Infections;response;Role;Serine Protease;Site;Source;Structure of parenchyma of lung;System;targeted treatment;Thrombospondin 1;tissue injury;Translating;Type II Secretion System Pathway;Virulence;Virus;Work

PROJECT_TITLE: Mechanisms of host protection against pathogen-associated proteases in acute lung injury

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Pregnancy;Prevention;Primary Health Care;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE One in six Americans report at least four adverse childhood experiences, an exposure that increases the risk of mental health conditions later in life and specifically in the perinatal period. This rigorous hybrid type 2 randomized controlled trial will optimize strategies to implement TRIO, a trauma-informed interpersonal therapy-based program based on the ROSE intervention, using the collaborative care model, for low income pregnant and postpartum people with a history of adverse childhood experiences. We will evaluate acceptability, appropriateness, cost, feasibility, and fidelity of the intervention as well as preliminary efficacy data with the goal of informing the design of a planned definitive cluster randomized effectiveness trial.

PI_NAMEs: FISHER, SHEEHAN DAVID (contact);MILLER, EMILY STINNETT

PROGRAM_OFFICER_NAME: CHU, SERENA PO-LAN

PROJECT_TERMS: Adult;adverse childhood events;Adverse effects;adverse outcome;American;anxiety symptoms;Attention;Belief;Birth;care systems;Caring;Case Manager;Childhood;childhood adversity;Clinic;Clinical;Cluster randomized trial;collaborative care;Communication;cost;Data;depression prevention;Depressive disorder;depressive symptoms;design;Diagnosis;Discipline;Discipline of obstetrics;Dissemination and Implementation;Divorce;Dose;Effectiveness;effectiveness evaluation;effectiveness trial;effectiveness/implementation design;effectiveness/implementation trial;Eligibility Determination;emotional abuse;Enrollment;Equity;evidence base;Exclusion;experience;Exposure to;follow-up;Foundations;Generations;Goals;Health Services;Healthcare;Hybrids;implementation evaluation;implementation intervention;implementation outcomes;implementation strategy;improved;improved outcome;Individual;Infrastructure;Infusion procedures;intergenerational;interpersonal therapy;Intervention;Interview;Investigational Therapies;Justice;Life;Life Experience;Low income;Low Income Population;Major Depressive Disorder;Masks;Maternal and Child Health;Measures;Mediator;Medical;Medical Care Team;meetings;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Meta-Analysis;Methods;Modeling;Mothers;multidisciplinary;neglect;obstetric care;offspring;Outcome;Participant;Pathogenicity;patient registry;Perinatal;perinatal period;peripartum depression;Persons;physical abuse;Population;Postpartum Period;Poverty;Pregnancy;pregnant;prevent;Prevention;prevention service;preventive intervention;primary care setting;primary outcome;Process;programs;Provider;Public Health;public health insurance;Publishing;Randomized;randomized effectiveness trial;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Reporting;reproductive;Research;Research Personnel;Research Training;response;Risk;screening;secondary outcome;Self Efficacy;service intervention;service programs;Services;Sexual abuse;social adversity;Social support;socioeconomics;stress symptom;Structural Racism;Structure;Symptoms;therapy design;Third Pregnancy Trimester;Trauma;traumatic event;treatment as usual;Treatment Protocols;United States

PROJECT_TITLE: Prevention of Perinatal Depression in Birthing People with a History of Adverse Childhood Experiences: A Type 2 Effectiveness Implementation Trial


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: St. Louis

ORG_NAME: GATEWAY BIOTECHNOLOGY, INC.

PHR: PROJECT NARRATIVE Age-related hearing loss or presbycusis is the most prevalent neurodegenerative disease and number one communication disorder of our aged population; and affects hundreds of millions of people worldwide. Here, I will develop a clinical diagnosis tool to detect age- related cochlear synaptic loss. Through this funding, I will also receive training in medical device development and commercialization, and become an industry leader in this field.

PI_NAMEs: PINKL, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Affect;age related;age related biomarkers;Aging;aging population;aging related disease;analytical method;Animal Model;Animals;Auditory Brainstem Responses;Autopsy;Businesses;Calibration;CBA/CaJ Mouse;clinical diagnosis;clinical diagnostics;clinical practice;Cochlea;cochlear synaptopathy;commercialization;Communication impairment;Computer software;Data;Data Analyses;Data Collection;design;detection sensitivity;Development;Device or Instrument Development;Devices;Diagnosis;diagnostic tool;Early Diagnosis;Electrocochleographies;Electronics;Electrophysiology (science);Equipment;Funding;Gerbils;Goals;Hearing;hearing range;hidden hearing loss;Histologic;Histology;Human;Impairment;improved;Industry;Inner Hair Cells;Longitudinal Studies;Machine Learning;Measurable;Measurement;Measures;Medical Device;Methods;mouse model;multidisciplinary;Mus;Neurodegenerative Disorders;Neurons;Newly Diagnosed;Noise;noise perception;Participant;Pathology;Persons;Physiologic pulse;Physiological;preclinical study;Presbycusis;prevent;Prevention;Prevention strategy;Principal Investigator;ribbon synapse;Sample Size;skills;sound;Speech;speech in noise;spiral ganglion;Synapses;Testing;Time;tool;Training;training opportunity;Validation

PROJECT_TITLE: Developing a clinical diagnostic tool for age-related cochlear synaptopathy.


ADMINISTERING_IC: FD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: FAYETTEVILLE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: Project Narrative of the Indigenous Food and Agriculture Initiative at the University of Arkansas: RFA-FD-23-032, Renewal-Native American Tribes Outreach, Education, and Training to Enhance Food Safety and FSMA Compliance The work of the Tribal Food Safety Alliance ensures that 80,000+ Tribal growers and Tribal Na>ons opera>ng food businesses have access to the specialized educa>on and training they need to promote food safe prac>ces in their opera>ons in a way that incorporates tradi>onal Indigenous food science and ways of knowing. This work is signiﬁcant to public health because it helps further a na>onal integrated food safety network that lessens the possibility of foodborne illness outbreaks causing sickness, impairment, and even death.

PI_NAMEs: SHEDD, STEVEN  (contact)

PROGRAM_OFFICER_NAME: GALAGARZAANGULO, OSCAR

PROJECT_TITLE: Native American Tribes Outreach, Education, and Training to Enhance Food Safety and FSMA Compliance: Tribal Food Safety Alliance


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Hematology;Lung

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Submassive pulmonary embolism (PE) is a common dangerous disease that often causes cardiopulmonary disability, reduced functional capacity, and decreased quality of life. Catheter-directed therapy (CDT), by acutely reducing clot burden and improving right ventricular function, has the potential to prevent these long- term complications. This study will determine if CDT in addition to anticoagulant therapy, rather than anticoagulant therapy alone, should be used to treat patients with submassive PE.

PI_NAMEs: RAO, SUNIL V (contact);VEDANTHAM, SURESH

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: Activities of Daily Living;Acute;American;Anticoagulant therapy;Anticoagulation;Award;Benefits and Risks;Berry;Blinded;Blood Pressure;Cardiopulmonary;Cardiopulmonary Physiology;Catheters;Cessation of life;Chronic;Classification;Clinical;clinical practice;Clinical Trials;Clinical Trials Network;Coagulation Process;Consultations;cost;cost comparison;cost effectiveness;cost per quality-adjusted life year;Dangerousness;Deterioration;disability;Disease;Dose;efficacy outcomes;efficacy study;Enrollment;Excision;exercise capacity;Exercise Test;feasibility trial;Fibrinolytic Agents;functional status;Futility;Gatekeeping;Grant;Health;Heart;hemodynamics;Hemorrhage;high risk;image guided;Impairment;improved;incremental cost-effectiveness;innovation;Measures;Methodology;Mission;mortality;National Heart, Lung, and Blood Institute;New York;open label;optimal treatments;Outcome;Outcome Study;Oxygen Consumption;Patients;Peripheral;Phase;Prediction of Response to Therapy;prevent;Procedures;Professional Organizations;Public Health;Pulmonary artery structure;Pulmonary Embolism;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recurrence;Research Priority;Resources;Right Ventricular Dysfunction;Right Ventricular Function;Risk;safety outcomes;Sample Size;Science;secondary outcome;SF-36;Shortness of Breath;Survivors;symposium;Symptoms;targeted delivery;Techniques;Technology;Testing;thrombolysis;Thrombolytic Therapy;Thrombus;treatment group;Veins;venous thromboembolism;Walking

PROJECT_TITLE: 1/2 Pulmonary Embolism: Thrombus Removal with Catheter-Directed Therapy (PE-TRACT Trial)

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Despite the rapidly growing population of older Asian Americans, their participation in clinical research for Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) remains historically low – masking health disparities in this minority group. Social determinants of health (SDOH) are the conditions in the environment that affect an individual’s overall health and quality of life. This proposed study will investigate mechanisms involved in the relationship between SDOH and AD/ADRD outcomes, as well as identify vascular risk factors and novel biomarkers for predicting AD/ADRD using modern systems biology and machine learning based approaches.

PI_NAMEs: CAI, DONGMING ;LI, CLARA  (contact);SPAT-LEMUS, JESSICA ;ZHANG, BIN

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Acceleration;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Anxiety;apolipoprotein E-4;Area;Asian Americans;Assessment tool;Attention;Behavior;Behavioral;Biological Factors;Biological Markers;Biology;Blood Cells;Blood specimen;Blood Vessels;built environment;Chinese;Chronic;clinical phenotype;Clinical Research;Cognitive;Cognitive deficits;cognitive testing;cohort;Collaborations;Collection;Communities;community based participatory research;Cross-Cultural Comparison;Data;Dementia;dementia risk;Demographic Factors;Development;Diabetes Mellitus;Diagnostic;Disease Outcome;Economics;education access;Enrollment;Environment;Etiology;Evaluation;executive function;follow-up;functional status;Genetic;genome sequencing;Genomics;Goals;Health;health assessment;health care availability;health disparity;health inequalities;Heterogeneity;Hypertension;Immigration;indexing;Individual;Language;Learning;Linguistics;Link;Machine Learning;Masks;Measurement;Measures;Mediating;member;Memory;Mental Depression;Minority Groups;Modernization;molecular marker;Molecular Profiling;multidisciplinary;Neighborhoods;Neurobiology;neuropsychiatric symptom;novel;novel marker;older adult;Older Population;Outcome;Participant;Pathway interactions;Pattern;Personal Satisfaction;Phase;pilot test;Plasma;Play;Population;precision medicine;predictive marker;Preparation;Process;prognostic;Proteomics;Quality of life;recruit;Research;Research Infrastructure;Research Methodology;Risk;Risk Factors;Sampling;skills;social;Social Adjustment;social culture;social health determinants;Social Sciences;sociodemographic factors;Systems Biology;Testing;theories;transcriptome sequencing;Translations;Underrepresented Minority;vascular risk factor;Visuospatial;Whole Blood;whole genome;Work;Writing

PROJECT_TITLE: Research Infrastructure for the study of Alzheimer's Disease and Alzheimer's Disease-related dementias in older Asian Americans


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: The population of the US is aging rapidly, with considerable growth in Latinx older adults. The increase in the minority population will tremendously impact the public health systems. Understanding the determinants of health in the Latinx population and contrasting them to other racial/ethnic groups will provide better preventive strategies for the Latinx minorities and help lessen the growing Alzheimer's and dementia epidemic in the US.

PI_NAMEs: KRUEGER, KRISTIN R;RAJAN, KUMAR B. (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Address;Adult;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;apolipoprotein E-4;Behavioral;Biological;Biological Markers;biracial;Black race;Blood;Blood specimen;cardiovascular risk factor;Censuses;Chicago;Clinical;clinical diagnosis;cognitive function;cognitive testing;cohort;Cohort Studies;Collection;Communities;community engagement;community organizations;Community Outreach;COVID-19;COVID-19 impact;COVID-19 outbreak;COVID-19 pandemic effects;Data;Data Collection;Death Rate;Dementia;design;Epidemic;Ethnic Origin;Ethnic Population;Event;Exhibits;experience;Focus Groups;Future;Genetic;Goals;Grant;Growth;Health;health determinants;health inequalities;Health system;Height;High Prevalence;Hispanic;Hispanic Populations;Household;human old age (65+);Impaired cognition;improved;Incidence;Individual;infection rate;Infrastructure;Knowledge;Latinx;Latinx population;Life Style;member;mild cognitive impairment;Minority;Minority Groups;minority health;minority health disparity;multi-ethnic;Neighborhoods;Nervous System Disorder;Not Hispanic or Latino;novel;older adult;Participant;Pathology;Perception;Persons;Phase;Population;population based;population health;Population Study;Prevalence;Prevention strategy;Procedures;Protocols documentation;psychologic;psychosocial;Public Health;Race;racial difference;racial population;Recommendation;recruit;Research;Research Infrastructure;Research Project Grants;research study;Resource Sharing;Resources;Risk;Risk Factors;Sampling;Side;social;social determinants;Spanish/English;success;Testing;tool;U-Series Cooperative Agreements;United States National Institutes of Health;Update;Washington;web site

PROJECT_TITLE: A Population-Based Latinx Community Study of Alzheimer’s Disease


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BOZEMAN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: NARRATIVE  The goal of this project is to provide in-depth research experiences, career training and mentorship to underrepresented minority graduates in Montana, including Native Americans, and rural first generation and/or low-income students, so that they can successfully transition into doctoral degree programs in the biomedical sciences. To accomplish this goal, we have designed an evidence-based postbaccalaureate program, PREP- MT, that will equip recent minority graduates (“PREP scholars'') with the experience, knowledge, research skills and confidence to become highly successful PhD students and graduates.

PI_NAMEs: BIMCZOK, DIANE  (contact);EGGERS, MARGARET ;KOMINSKY, DOUGLAS J;SIMONDS, VANESSA WATTS

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Agreement;Alaska Native;American Indians;Area;Bachelor's Degree;Basic Science;Biomedical Research;bridge to the baccalaureate;career;Collaborations;Communities;Cultural Sensitivity;Degree program;design;Development Plans;Doctor of Philosophy;Doctor's Degree;doctoral student;education research;Enrollment;Event;evidence base;experience;Exposure to;Faculty;First Generation College Students;Funding;Generations;Goals;Graduate Degree;graduate school;graduate student;Graduation Rates;Grant;Home;improved;Indigenous;Individual;Inequity;Information Dissemination;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Knowledge;Leadership;Low income;member;Mentors;Mentorship;Minority;Minority Access;Minority Graduate Student;Minority Groups;minority undergraduate;Mission;Montana;Native Americans;next generation;Participant;peer coaching;Population;Positioning Attribute;Postbaccalaureate;posters;Professional Competence;program dissemination;Program Evaluation;programs;Publications;Qualifying;recruit;Reproducibility;Research;research facility;Research Methodology;Research Support;Research Training;Resources;responsible research conduct;retention rate;role model;Rural;rural area;Rural Community;Scholars Program;Science;Scientist;skills;Social Sciences;Structure;Students;support network;symposium;Talents;Training;training opportunity;Training Programs;Translational Research;tribal college;tribal community;tribal Nation;Tribes;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Work;Workforce Development;Writing

PROJECT_TITLE: PREP-MT: Providing Research Education for Postbaccalaureate Trainees in Montana

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Motivated by the insight that overcoming centuries of structural racism will require significant concentrated  investment in the structures that have left Black people and Black neighborhoods in peril, we propose a cluster  randomized controlled trial of a suite of place-based and financial-wellbeing interventions delivered at the  community, organizational, and individual/household levels. Designed to target many of the key mechanisms  by which structural racism results in racial health disparities among Black adults in Philadelphia, we  hypothesize that because the interventions will be implemented simultaneously in targeted micro-geographic  areas, positive health impacts will be multiplied and longer-lasting than has accrued by more traditional  individually focused interventions. Upon completion, the proposed research will provide policymakers,  communities, and health systems with innovative, timely, and scalable evidence on new strategies that can  meaningfully close long-standing racial health disparities.

PI_NAMEs: SOUTH, EUGENIA C (contact);VENKATARAMANI, ATHEENDAR S.

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Address;Adult;adverse childhood events;Affect;Behavior;Birth;Black American;Black Populations;Black race;Blood Pressure;Chronic Disease;Cities;Communication;Communities;community engagement;community violence;Counseling;Criminology;data infrastructure;design;Diabetes Mellitus;Disadvantaged;Discrimination;Disparity;Distress;Economic Conditions;Economics;Emergency Situation;empowerment;Evaluation;Evidence based intervention;Exposure to;Feedback;Financial Hardship;Food;food insecurity;Geographic Locations;Health;health disparity;health equity;health inequalities;Health system;Healthcare;Household;Hypertension;implementation science;improved;Individual;Infrastructure;innovation;insight;Institution;Intervention;Investments;Lead;Left;Life Expectancy;Link;Location;Longevity;Low Birth Weight Infant;Malignant Neoplasms;Maternal Health;Measurable;Methods;Neighborhoods;novel;novel strategies;Outcome;Pathway interactions;Pattern;Personal Satisfaction;Persons;Philadelphia;Plants;Policy Analysis;Policy Maker;Population;poverty alleviation;Premature Birth;Preparation;Provider;psychosocial;Public Health;Race;racial disparity;racial diversity;racial health disparity;racial population;Randomized, Controlled Trials;remediation;Research;Resources;Rewards;Risk;Security;segregation;Services;Shoulder;social;Social Conditions;social determinants;social health determinants;social stressor;Structural Racism;Structure;Taxes;Testing;Toxic Environmental Substances;Translating;Trees;United States;Violence;Youth

PROJECT_TITLE: A Randomized Controlled Trial of Concentrated Investment in Black Neighborhoods to Address Structural Racism as a Fundamental Cause of Poor Health


PHR: Hypothalamic tanycytes are radial glial cells that closely resemble neural progenitors in morphology and gene expression profile, as well as retain a limited ability to generate neurons postnatally but are undetectable in adult animals. Identifying intrinsic (Ascl1) and extrinsic (Shh signaling) factors that stimulate neurogenic competence in tanycyte and differentiation of tanycyte-derived neurons that modulate body weight, could potentially be a useful means of treating obesity and metabolic disorders such as type II diabetes. In the K00 phase, I will pursue postdoctoral training to understand injury-induced neurogenic competence in Danio reiro (zebrafish) tanycytes, and gene regulatory networks controlling the regeneration of the zebrafish hypothalamus.

PI_NAMEs: DUNCAN, LEIGHTON HOSEA (contact)

PROJECT_TERMS: Ablation;Acute;Adolescent;Adult;Affect;Apoptotic;Award;Biology;Body Weight;career;career development;Cell Death;Cell Physiology;cell regeneration;cell type;Cells;cold blooded vertebrate;Competence;Data;Development;differential expression;Disease;Educational workshop;Family;Funding;Gene Expression Profile;gene regulatory network;Generations;genetic approach;Genetic Models;Genomics;Hypothalamic structure;Injections;Injury;Institution;insulinoma associated 1;Intrinsic factor;Knowledge;mature animal;Mechanics;Mediating;Metabolic;Metabolic Diseases;Metabolism;Modeling;Molecular;Morphology;multiple omics;Mus;Natural regeneration;Nerve Regeneration;nerve stem cell;neural;neurogenesis;Neuroglia;Neurons;Non-Insulin-Dependent Diabetes Mellitus;notch protein;nuclear factor 1;Obesity;overexpression;Phase;post-doctoral training;postnatal;postnatal development;pre-doctoral;Principal Investigator;Proliferating;Radial;Repression;Research;Rest;Retina;Role;Signal Transduction;single-cell RNA sequencing;SOX8 gene;stem;Surgical Models;symposium;Tamoxifen;Techniques;Telencephalon;Testing;Therapeutic;Training;transcription factor;transcriptomics;Virus;young adult;Zebrafish

PROJECT_TITLE: Intrinsic and Extrinsic factors regulating neurogenic competence in hypothalamic tanycytes


NIH_SPENDING_CATS: Bioengineering;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DREXEL UNIVERSITY

PHR: NARRATIVE The proposed studies will reveal the intrinsic properties of spinal neurons, neuronal interactions, and organization of spinal circuits involved in the generation of locomotor rhythm. A better understanding of the spinal neural mechanisms controlling locomotion will provide essential insights for the development of future clinical strategies to restore and promote motor functions by identifying specific targets for recovery of locomotion in spinal cord injury and motor disorders.

PI_NAMEs: DOUGHERTY, KIMBERLY J (contact);RYBAK, ILYA A

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TITLE: Mechanisms of locomotor rhythm generation in rodent spinal cord


ORG_CITY: RICHMOND

ORG_DEPT: PATHOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: NARRATIVE As people age, some of their body cells acquire genetic changes. A newly recognized type of acquired genetic change, called cytosolic DNA, has emerged as an important player in either triggering or mediating other age-related biological alterations that can lead to health conditions. By studying identical and fraternal twins, over a time frame of 10 to 15 years, we will determine the frequency of cytosolic DNA, discover if it occurs due to a genetic predisposition or environmental factors, characterize the types of cytosolic DNA and their stability over time, and identify relationships between cytosolic DNA and other age-related biological changes; all of which is knowledge that is needed to develop targeted therapies to reduce/alleviate age-related health conditions.

PI_NAMEs: JACKSON-COOK, COLLEEN K (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Age;age related;age related biomarkers;Aging;Algorithms;Atomic Force Microscopy;Basic Science;beta-Galactosidase;bioinformatics tool;Biological;Biological Assay;Biological Markers;Blood;Cell Physiology;Cells;Chromatin;Chromosomes;Chronic;Circular DNA;cohort;CRISPR/Cas technology;cytokine;Data;design;Development;Dizygotic Twins;DNA;DNA Methylation;Early Diagnosis;Early treatment;efficacy testing;Environment;Environmental Risk Factor;Epigenetic Process;Fluorescent in Situ Hybridization;Frequencies;Functional disorder;Future;Gene Expression Profile;Genes;Genetic;genetic makeup;Genetic Predisposition to Disease;Genome;genome-wide;Germ Lines;hallmarks of aging;Health;Health Sciences;Homeostasis;Human;Human Chromosomes;Immunologic Surveillance;Individual;Individual Differences;Inflammation;innate immune pathways;Interferons;Knowledge;Length;Longitudinal Studies;Measures;Mediating;Mediator;Methods;Methylation;methylation pattern;micronucleus;Mitochondria;Modeling;Monozygotic twins;Mutation;neuronal cell body;new therapeutic target;novel;Oral mucous membrane structure;Outcome;Pathway interactions;Pattern;Persons;Pharmacogenomics;Play;Ploidies;predictive tools;Predisposition;Protocols documentation;Quantitative Genetics;reduce symptoms;Resolution;response;Role;screening;senescence;Site;Somatic Cell;Source;Specimen;Spectral Karyotyping;Statistical Models;Stimulator of Interferon Genes;targeted treatment;Technology;telomere;Telomere Maintenance;Testing;Time;Tissues;tool;trait;transcriptome;transcriptomics;Twin Multiple Birth;Twin Studies;Variant

PROJECT_TITLE: Cytosolic DNA, Telomeres/Subtelomeres, and Epigenetics: A Longitudinal Twin Study to Assess the Role of Genetics and Environment on their Frequency and Inter-relationships

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Dementia;Microbiome;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is a pathology associated with inflammation, tau phosphorylation, and amyloid accumulation. Many modulators of these neurodegenerative processes come from the interaction of the brain- gut-microbiome axis and the production of bacterial metabolites. Our central hypothesis is that gut microbiota dysbiosis after traumatic brain injury (TBI) contributes directly to the inflammatory response in AD brains and that precision microbiota therapy will restore dysbiosis and preserve protective gut signals in AD pathogenesis. Manipulating the gut microbiota could serve as a therapy for AD patients after TBI.

PI_NAMEs: VILLAPOL, SONIA  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: abeta accumulation;Ablation;Acceleration;Acute;Affect;Aftercare;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;Antibiotics;Anxiety;APP-PS1;Bacteria;bacteriome;Behavior;behavior test;bone;Brain;Brain Injuries;Chronic;Cognitive deficits;cognitive function;Communication;Computer Analysis;Data;Dementia;Deposition;design;Disease Progression;DNA sequencing;dysbiosis;Elderly;Encephalitis;Engraftment;Environmental Risk Factor;Event;experimental study;extracellular;fall risk;falls;fecal transplantation;Flow Cytometry;Foundations;Functional disorder;Gastrointestinal Physiology;Germ-Free;global health;gut bacteria;gut microbiome;gut microbiota;gut-brain axis;high risk;Hip region structure;Hospitals;Immune;immune activation;Immune system;Impaired cognition;improved;Inflammation;Inflammatory;Inflammatory Response;injured;Intervention;Lactobacillus;Mediating;Mental Depression;Metabolic;metabolomics;metaproteomics;microbial;microbiome;microbiome composition;microbiota;microbiota-gut-brain axis;Microglia;motor deficit;mouse model;multidisciplinary;Mus;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neurological outcome;Neuromodulator;neuropathology;next generation;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient population;Persons;Phase;Play;preservation;Probiotics;Process;Production;Proteins;Recovery;Rehabilitation therapy;Research Proposals;response;restoration;Role;Severities;Signal Transduction;tau aggregation;tau Proteins;tau-1;Testing;Tg2576;Therapeutic;Traumatic Brain Injury;Traumatic Brain Injury recovery;Traumatic CNS injury;Vulnerable Populations

PROJECT_TITLE: Microbiota-targeted approaches to resolve dysbiosis-induced AD neuropathology following brain injury.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)]


ORG_NAME: NYTRICX INC.

ORG_STATE: GA

PHR: Narrative Nytricx is developing a new class of Nitric Oxide (NO)-releasing intravascular medical catheters to combat infection and thrombosis associated with indwelling vascular catheters. Nytricx NO-releasing technology represents a disruptive innovation that will result in saving patients’ lives and cutting medical costs, especially those related to hospital acquired blood steam infections and thrombosis, associated with intravascular catheters.

PI_NAMEs: SHEBUSKI, RONALD J. (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Adhesions;Affect;Anti-Infective Agents;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Back;Bacteremia;Bacteria;Bacterial Adhesion;base;Binding;Bioreactors;Blood;Blood coagulation;Blood Platelets;Blood Vessels;Body part;catheter related infection;Catheters;Cells;Cessation of life;Chronic;chronic infection;Clinical;combat;Communities;Data;design;Development;Devices;Environment;Extracellular Matrix;Failure;Fibrinogen;Frequencies;Gases;Glycocalyx;hemocompatibility;Hemolysis;Heparin;Hospitals;Human;hydrophilicity;Immobilization;Immune;In Vitro;in vivo;Infection;Infection prevention;innovation;Invaded;Kinetics;Life;Liquid substance;Mechanics;Medical;Medical Care Costs;Microbial Biofilms;microorganism;Modeling;mortality;Nitric Oxide;Nitric Oxide Donors;Nosocomial Infections;novel;Nutritional;Oryctolagus cuniculus;Patients;pharmacologic;Phase;physical property;Platelet Activation;Polymers;prevent;Prevention;Proliferating;Property;Protein Structure Initiative;Proteins;Pseudomonas aeruginosa;Reporting;Resistance;Risk;side effect;Silicone Oils;Silicones;Solid;stability testing;Staphylococcus aureus;Steam;Stream;Surface;Technology;Temperature;Tensile Strength;Therapeutic Embolization;Thromboembolism;Thrombosis;thrombotic;Thrombus;Time;Veins;venous thromboembolism;Venous Thrombosis

PROJECT_TITLE: Ultra-low Fouling and Anti-infective and Anti-thrombotic Nitric Oxide Releasing Intravascular Catheters


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Dementia;Digestive Diseases;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Pain Research

PHR: Abdominal pain in patients over 65 years old is very common, causing 1.4 million emergency department visits per year. Older adults who develop abdominal pain severe enough to seek care at an emergency department have poor health outcomes, including death, as often as patients who develop a heart attack. This proposal seeks to understand how care of this patient population is managed—especially for patients with impaired cognition, Alzheimer's disease and related dementias, and/or frailty—so that it can ultimately be understood and improved.

PI_NAMEs: FRIEDMAN, ARI B (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Abdomen;Abdominal Pain;Abdominal Radiography;Accident and Emergency department;Acute;Acute Disease;Admission activity;Adult;Affect;Age;Aging;Alzheimer's disease related dementia;Analgesics;Award;Benign;Biological Models;care seeking;care systems;career;career development;Caring;Cessation of life;clinical practice;Cognitive;cognitive function;cohort;Communication Barriers;Data;Data Collection;Data Sources;Death Rate;Delirium;Dementia;Development Plans;Diagnosis;Diagnostic tests;Disease;Disparity population;disparity reduction;Doctor of Philosophy;Elderly;Electrocardiogram;Electronic Health Record;Emergency Care;Emergency Department patient;Emergency Department Physician;Emergency department visit;Emergency Medicine;emergency settings;Emergent care;Enrollment;Environment;Equilibrium;Evaluation;Face;Faculty;Fostering;frailty;Funding;Future;Geriatrics;Gerontology;Goals;Health;health disparity;health economics;Health Services Research;high risk;Hospitalization;Hospitals;human old age (65+);Impaired cognition;improved;Infection;Infrastructure;Institution;Intestinal Obstruction;Ischemia;K-Series Research Career Programs;Knowledge;Link;Longitudinal cohort;Measurement;Measures;Mediating;Medical;Medicare;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Mesentery;mild cognitive impairment;Morbidity - disease rate;mortality;mortality risk;multiple chronic conditions;Myocardial Infarction;Natural History;Neurocognitive;older adult;older patient;Outcome;Pain;pain patient;Pathway interactions;Patient Admission;Patient Care;patient population;patient subsets;Patients;Patterns of Care;Pennsylvania;Persons;Physical Function;Physiological;poor health outcome;prospective;Quality of Care;Race;Research;Research Personnel;Resources;Risk;Scholarship;Science;Secure;sex;side effect;skill acquisition;skills;Sociology;Source;Structure;success;Symptoms;Syndrome;System;Testing;Time;Training;Trauma;Triage;Universities;Variant;Visit;Work;X-Ray Computed Tomography

PROJECT_TITLE: Abdominal Pain in Older Patients in Emergency Departments

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Harmful menstrual practices, such as chhaupadi (menstrual seclusion) in Nepal, are an urgent threat to women’s health, wellbeing, and development. This study will investigate underlying mechanisms of promising aspects of chhaupadi interventions to date and build upon these findings to co-design and pilot test a context- specific intervention in partnership with community members. In the short-term, outcomes from this proposal will advance the field by resulting in 1) a pilot tested intervention that can be further tested in a future randomized controlled trial, 2) a refined approach for engaging communities in sustainable and contextually appropriate intervention co-design that is expected to be applicable to other low- and middle-income country contexts, and 3) in the longer-term support public health efforts aiming to reduce the negative health effects of harmful menstrual practices on women in Nepal.

PI_NAMEs: BAUMANN, SARA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: acceptability and feasibility;Active Learning;Address;Area;Attitude;Attitude to Health;Awareness;Behavior Therapy;behavioral health;Behavioral Model;career;career development;Cessation of life;Clinical Trials;Clinical Trials Design;Collaborations;Communities;community collaboration;community engaged approach;community engaged intervention;community engaged research;community engagement;Community Health;comparison control;Data;design;Development;Development Plans;Discrimination;Educational Curriculum;Educational Models;Educational workshop;Ensure;Environment;Evaluation;Exclusion;Failure;Family;Feedback;Focus Groups;Future;gender-based violence;girls;global health;Goals;Grant;Health;Health behavior;health knowledge;Health Sciences;human centered design;Human Rights;implementation science;improved;Individual;Infection;informant;innovation;International;Intervention;Intervention Studies;Interview;Leadership;Life;Literature;Loneliness;low and middle-income countries;meetings;member;Menstruation;Mental Health;Mentors;Mentorship;Methodology;Modeling;Morbidity - disease rate;mortality;Mothers;multidisciplinary;Nepal;Outcome;Participant;Personal Satisfaction;physical abuse;physical conditioning;Physiological Processes;pilot test;postnatal period;Process;professor;psychosocial;Public Health;Public Health Schools;Randomized;Randomized, Controlled Trials;Religion;Reporting;Reproductive Health;Research;research and development;Research Personnel;Resource-limited setting;Risk;role model;Safety;Schools;Self Efficacy;self esteem;skill acquisition;skills;Sleep;sleep difficulty;Snake Bites;social;social situation;social stigma;standardize measure;Statistical Data Interpretation;Stigmatization;success;Surveys;Testing;Theoretical model;therapy design;therapy development;Training;United States National Institutes of Health;Universities;Update;uptake;Validation;Woman;Women's Health;women's reproductive health;Work;Writing;Youth

PROJECT_TITLE: Improving Menstrual Health Among Women and Girls Using Community Engaged Intervention Development in Nepal


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative We propose to develop a unique three-dimensional (3D) human mini-glioblastoma (GBM) model through the utilization of a light-based bioprinting technology and taking advantage of primary neuronal, vascular, and GBM cells, to more precisely replicate the brain tumor microenvironment in human patients. The construction of a high-content in vitro 3D human mini-GBM model mimicking not only the cellular compositions but also the extracellular matrix properties and importantly, tissue architecture of its in vivo counterpart, will allow us to precisely assess proliferation, migration, and transformation of GBM cells, at higher availability and throughput for potential drug screening in the future.

PI_NAMEs: QUINONES-HINOJOSA, ALFREDO ;ZHANG, Y. SHRIKE  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Actins;Affect;Architecture;Astrocytes;Behavior;Biocompatible Materials;bioink;Biological;Biology;bioprinting;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier crossing;Brain;Brain Neoplasms;Cell Communication;Cell Line;cell motility;Cell Therapy;cell type;Cells;Characteristics;chemoradiation;Communication;Complex;Coupled;Data;design;digital;Disease;Drug Screening;Endothelial Cells;Engineering;Environment;experience;Extracellular Matrix;FDA approved;Focal Adhesions;Future;Glioblastoma;Growth;Human;Immune;improved;In Vitro;in vitro Model;in vivo;in vivo Model;inhibitor;interest;Light;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Methodology;migration;Modeling;Molecular;Mus;Neurons;next generation;novel therapeutics;Operative Surgical Procedures;Outcome;Patients;Pericytes;Pharmaceutical Preparations;Physiological;Proliferating;Property;Quinones;Reaction;Rest;Role;Scheme;screening;Signal Transduction;spheroids;standard of care;System;Technology;Testing;Therapeutic Agents;Tissue Model;Tissues;tool;translational potential;treatment response;tumor;tumor microenvironment;tumor progression;Vascularization;Verteporfin

PROJECT_TITLE: A Bioprinted Volumetric Model of Vascularized Glioblastoma

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Digestive Diseases;Neurosciences

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The area postrema, a brain circumventricular sensory organ regulated by both humoral signals and inputs from the gastrointestinal tract, plays a critical role in nausea and aversive behaviors. During my postdoctoral fellowship, I identified and characterized a population of area postrema neurons which mediates aversive behaviors, and here I will specify and map both humoral and vagal inputs to these area postrema neurons and understand their physiological effects. Acquiring expertise required to achieve these aims, namely hormone signaling and functional circuit mapping, will enable me to establish an independent research program which focuses on the cellular and neural mechanisms of nausea combining mice and vomiting animals, and may lead to the development of novel anti-emetic therapies.

PI_NAMEs: ZHANG, CHUCHU  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Ablation;Adverse effects;Afferent Neurons;Anatomy;Animal Model;Animals;Anti-emetics;Atlases;Behavior;behavioral study;Biological Assay;Blood - brain barrier anatomy;Brain;cancer therapy;career;Cell Surface Receptors;cell type;Cells;Chemoreceptors;Communication;Cues;design;Development;Diabetes Mellitus;Educational process of instructing;Electrophysiology (science);Emetics;Esthesia;excitatory neuron;experimental study;Feeding behaviors;Fellowship;Food Poisoning;Gastrointestinal tract structure;GCG gene;GDF15 gene;Genetic;genetic signature;Genetic study;Goals;hormonal signals;Horns;Human;Hunger;Image;Imaging Techniques;In Vitro;Infection;Ingestion;inhibitory neuron;Knock-in Mouse;learned behavior;Learning;Lesion;Ligands;Location;Malaise;Malignant Neoplasms;Maps;Mediating;Mentors;Mentorship;Midbrain structure;Modeling;Molecular;Motion Sickness;Mus;Nausea;Nausea and Vomiting;neural;neuromechanism;Neurons;Neurosciences;novel;optogenetics;Organ;Orphan;parabrachial nucleus;pathogen;Peripheral;Phase;Physiological;Physiology;Play;Poison;Population;Positioning Attribute;Postdoctoral Fellow;Pregnancy;programs;receptor;Regulation;Research;response;Role;Route;Satiation;Sensory;sensory input;Shrews;side effect;Signal Transduction;single nucleus RNA-sequencing;skills;Specific qualifier value;Stimulus;Structure;Structure of area postrema;Techniques;Testing;Therapeutic;Thirst;Tissues;Toxin;Toxin Conjugates;Training;transcriptome;Viral;Visceral;Vocational Guidance;Vomiting

PROJECT_TITLE: Molecular and circuit mechanisms of nausea-associated behaviors


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: This large qualitative study of Gulf War Veterans will yield significant insight into the features of effective care models, treatments, and satisfaction with care. Interviews of Gulf War Veterans suffering chronic multisymptom illness by our team of experienced qualitative researchers will yield 1) significant insight into treatment regimens—from care both in- and outside the VA—that have the greatest patient benefit, 2) a more complete and nuanced understanding of symptoms that can be used for more directed treatment, and 3) publicly available resources that can be used by veterans, caregivers, clinicians, and researchers. It will also create a rich, ongoing resource that can inform VA’s effort to develop better care models for Gulf War veterans, identify better illness-specific health measures and promising therapeutic approaches, and activate veterans to be more engaged with the health system.

PI_NAMEs: NUGENT, SHANNON MADORE (contact)

PROJECT_TERMS: Acceleration;Administrator;Assessment tool;associated symptom;Audiotape;care delivery;care providers;Caregivers;Caring;Chronic;Clinical;clinical care;clinical practice;Clinical Services;Communication;Data;Data Collection;Databases;design;Development;Dissemination and Implementation;dissemination strategy;Ensure;Epidemiology;epidemiology study;Ethnic Origin;experience;Focus Groups;Gender Identity;Geographic Locations;Goals;Gulf War;Gulf War veteran;Health;Health Services Research;Health system;Healthcare;Healthcare Systems;Hearing;improved;Individual;individual patient;insight;instrument;Interview;Language;Libraries;Link;Literature;marginalization;Measures;Methodology;Methods;military veteran;Modeling;Needs Assessment;Outcome Assessment;Outcome Measure;Participant;patient oriented;Patient Outcomes Assessments;Patient Preferences;Patients;Pattern;Policies;policy recommendation;Process;Qualitative Methods;Questionnaires;Race;randomized trial;Recommendation;Regimen;Registries;repository;Research;Research Personnel;Resources;Sampling;satisfaction;Services;Sex Orientation;social exclusion;Socioeconomic Status;Structure;Survey Methodology;Surveys;symptom cluster;Symptoms;System;Testing;Therapeutic;Time;treatment center;Treatment Protocols;Universities;Update;Variant;Veterans;Voice;Work

PROJECT_TITLE: Listening to Gulf War Vets: A Qualitative Inquiry into the Health Experience and Treatment of those with Chronic Multisymptom Illness

STUDY_SECTION: SPLD

STUDY_SECTION_NAME: Special Emphasis - Research on Gulf War Veterans' Illnesses[SPLD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Hemianopia (contralateral blindness) is a severely debilitating disorder that is a common consequence of unilateral stroke or traumatic injury to the neocortex. The present study will examine the effectiveness of a novel technique for its rehabilitation using a primate model and will explore the nature of the recovered vision as well as the neural substrates that support it. The findings will provide essential insights into the mechanisms of multisensory-induced visual plasticity in the primate brain and inform future translational efforts to develop effective treatment regimens based on its underlying premise.

PI_NAMEs: ROWLAND, BENJAMIN A;STANFORD, TERRENCE R (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Animals;Area;Attention;Auditory;auditory stimulus;Awareness;base;Behavior assessment;Behavioral;Biological Models;blind;Blinded;Blindness;Brain;Clinic;Conscious;Contralateral;Cues;Data;Decision Making;Dedications;design;Detection;Development;Discrimination;Disease;effective therapy;Effectiveness;effectiveness evaluation;Equilibrium;Event;Family Felidae;Felis catus;Fostering;Foundations;Future;Goals;Hemianopsia;Human;insight;interest;Intervention;Investigation;Judgment;Knowledge;lateral intraparietal area;Learning;Methods;Modality;Modeling;Monkeys;multisensory;Nature;Neocortex;neural;neural circuit;neural correlate;Neurobiology;neuromechanism;Neuronal Plasticity;Neurons;neurophysiology;Neurophysiology - biologic function;nonhuman primate;novel;novel strategies;operation;Outcome;patient engagement;Patients;Pattern;Perception;Performance;Primates;Process;Property;Psychophysics;Quality of life;Recovery;Recovery of Function;Regimen;rehabilitation paradigm;Rehabilitation therapy;Reporting;response;restoration;Sensory;sensory integration;Signal Transduction;spatiotemporal;Stimulus;Stroke;success;superior colliculus Corpora quadrigemina;System;Techniques;Testing;Therapeutic;Training;translational approach;Trauma;Traumatic injury;Treatment Protocols;verbal;virtual;Vision;Visual;Visual Cortex;visual motor;visual plasticity;Visual Psychophysics;visual stimulus;Work

PROJECT_TITLE: Mechanisms of multisensory rehabilitation in a primate model of hemianopia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-U(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: NATIONAL OPINION RESEARCH CENTER

PHR: Project Narrative As we have yet to understand the multilingual caregiving experience of those living in an English-dominant society, health service providers are stymied in their response to Latino AD/ADRD patients and their ability to support family caregivers. By considering the cross-cultural and linguistic variability within caregivers’ social networks, this project aligns with NIA’s priorities to address the health of the nation’s aging population in the context of its changing demographics. Insights gleaned from this project could be relevant to other multilingual family caregivers.

PI_NAMEs: PIEDRA, LISSETTE  (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Acculturation;Acute;Address;Affect;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;bilingualism;care recipients;Caregivers;caregiving;Caring;Cognitive;cognitive interview;commune;Communication;Communities;Complex;Country;Cultural Characteristics;Data;Dementia;Dementia caregivers;demographics;English Language;experience;Family;Family Caregiver;family caregiving;Family member;family support;follow-up;Generations;Glean;Growth;Health;health care availability;health care settings;Health Services;Hispanic;Home;Household;improved;insight;Institution;Intensive Care;Internet;Interview;Language;Latino;Latino Population;Life;Light;Limited English Proficiency;Linguistics;Link;Longitudinal Studies;Measures;member;Mental Health;Methodology;Methods;Migrant;Motor;Multilingualism;older adult;Patients;peer;Personal Satisfaction;Persons;Pharmaceutical Preparations;phrases;physical conditioning;Play;Population;Protocols documentation;Provider;recruit;Research;Research Personnel;Respondent;response;Role;Sampling;Sensory;service providers;Services;skills;social;Social Network;social relationships;Societies;Spanish;Spanish/English;System;Telephone;Testing;Time;tool;Training;Translating;Translations;United States;Writing

PROJECT_TITLE: Enhancing NSHAP Caregiving & Social Network Measures to Contextualize Aging & Family Caregiving of AD/ADRD among English- and Spanish-speaking Latino Older Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-A(56)R]


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: Fundamental to diabetes treatment is the control blood sugar to delay the onset of complications such as eye and kidney problems. Effective treatment may be limited by concern over hypoglycemia (low blood sugar), a common and potentially hazardous side effect. To monitor for this side effect and improve the safety of care for Veterans with diabetes, this study will identify patients with hypoglycemia using patient surveys and searches of text in medical records for notation by clinicians. Other information will be collected in surveys and from the electronic health record and used in predicting which patients will have hypoglycemia. The best set of predictors will be used in assigning risks to diabetes patients. The new methods for finding hypoglycemia and identifying those diabetes patients at high risk will be applied in a national automated system for use in monitoring patient safety and improving care to reduce risks.

PI_NAMEs: BORZECKI, ANN MARIE (contact)

PROJECT_TERMS: Address;Adverse drug event;Adverse event;adverse outcome;Algorithms;Awareness;Blood Glucose;Blood Vessels;Cardiovascular system;Caring;case finding;Cessation of life;Classification;Clinical;Clinical Management;Code;Complication;contextual factors;Data;Decision Aid;Development;diabetes management;Diabetes Mellitus;Diagnosis;Documentation;effective therapy;Electronic Health Record;Evaluation;Event;experience;Eye;Fostering;Glucose;glycemic control;Goals;Health;high risk;Hospitalization;Human;Hyperglycemia;Hypoglycemia;improved;Incidence;innovation;Kidney;Laboratories;Measurable;Measures;Medical;Medical Records;Metabolic;Methodology;Methods;Modeling;Monitor;Natural Language Processing;operation;Outcome;Patient Monitoring;patient oriented;Patient Outcomes Assessments;patient population;Patient risk;patient safety;Patient Self-Report;Patients;Performance;personalized approach;point of care;Population;population health;precision medicine;prediction algorithm;predictive modeling;prevent;Prevention;Process;programs;Provider;Public Health;Quality of Care;Recommendation;Report (document);Research;Risk;Risk Adjustment;Risk Reduction;Safety;Sampling;Services;Severities;side effect;Source;Standardization;Structure;structured data;Subgroup;surveillance strategy;Surveys;System;Systems Integration;Technology;Testing;text searching;Time;tool;Validation;Veterans;Work

PROJECT_TITLE: Prediction and Prevention of Hypoglycemia in Veterans with Diabetes

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Dental, Oral, and Craniofacial Disease

ORG_CITY: WATERTOWN

ORG_NAME: RADIATION MONITORING DEVICES, INC.

PHR: Research & Related Other Project Information – Project Narrative This project is to develop a new construction of dental imaging technology that can provide both high resolution and high efficiency, the latter being important to reducing radiation dose from routine x-ray examinations. The innovative sensor will also be applicable to medical disciplines such as mammography and micro computed tomography.

PI_NAMEs: CHRISTIAN, JAMES F (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Adult;Bromides;Child;Chronic Disease;Collaborations;Computers;contrast imaging;cost;density;Dental;Dental caries;Dental Radiography;Dentists;Deposition;Detection;detector;Devices;Digital Radiography;digital technology;Digital X-Ray;Discipline;Dose;Electrodes;Engineering;Exposure to;fabrication;Film;Goals;high resolution imaging;Image;imager;imaging capabilities;imaging detector;imaging system;Imaging technology;improved;innovation;Investigation;Mammography;Medical;Methods;microCT;monitoring device;Patients;Performance;Phase;Population;Positioning Attribute;Procedures;Process;process optimization;professor;prototype;Public Health;Radiation Dose Unit;Radiation Monitoring;radiological imaging;receptor;Reproducibility;Research;Resolution;response;Risk;Roentgen Rays;scale up;Selenium;Semiconductors;sensor;Signal Transduction;Silicon;System;Techniques;Technology;Testing;Thallium;Thick;Tooth structure;United States;Universities;Work;X-Ray Medical Imaging

PROJECT_TITLE: Semiconductor detector for low-dose, high-resolution dental DR imaging


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence

PHR: Project Narrative Suicide is a leading cause of death among adolescents, and recently, problematic social media use has been linked to the emergence of suicidal thoughts and behaviors. By coupling biological measures–including neural and physiological markers–with deep interrogation of social media real-time interactions, there is enormous promise to elucidate suicide risk among adolescents. Collectively, this innovative approach will identify those who are susceptible to negative social media exposures and inform novel clinical targets, which will facilitate the development of preventative-intervention approaches that reduce the needless loss of life among young people.

PI_NAMEs: AUERBACH, RANDY PATRICK;MELHEM, NADINE M. (contact);PECINA, MARTA

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: 17 year old;Address;Adolescent;Age;Amygdaloid structure;Anterior;Biological;Biological Markers;Biological Process;Buffers;Cause of Death;Characteristics;Chronic;Clinical;Clinical assessments;Coupling;Data;Development;digital;Emergency department visit;Enrollment;Evaluation;Event;Exhibits;experience;Exposure to;Feedback;Feeling suicidal;follow up assessment;Functional Magnetic Resonance Imaging;Future;Generations;Goals;Hair;harassment;Hate;high risk;Hydrocortisone;hypothalamic-pituitary-adrenal axis;ideation;innovation;inpatient psychiatric treatment;Insula of Reil;Interruption;Interview;Lead;Life;Link;Measures;media use;Mediating;Mental disorders;Methods;Natural Language Processing;neural;neural correlate;neural network;novel;Pathway interactions;Patient Self-Report;peer;Persons;Physiological;Physiological Processes;Predisposition;preventive intervention;Process;Public Health;Recording of previous events;recruit;Reporting;Research;response;Risk;Risk Behaviors;Risk Factors;Sampling;Severities;social;social capital;Social Environment;social media;Social Network;Social Processes;Social support;Speech;Stress;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide rate;temporal measurement;Testing;theories;Time;Victimization;Violence;Youth

PROJECT_TITLE: Interpersonal Stress, Social Media, and Risk for Adolescent Suicidal Thoughts and Behaviors


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

ORG_CITY: GOLETA

ORG_NAME: BIOPAC SYSTEMS, INC.

ORG_STATE: CA

PHR: Narrative: This project aims to develop, test, and commercialize an optimized wireless recording system to study physiological biopotentials (e.g., the electroencephalogram (EEG)) in immature rodents. BIOPAC Systems, Inc. will design a novel temperature-controlled chamber to record wirelessly from rodent pups. This recording system, along with a novel antenna design and synchronized video system, will improve basic-science and preclinical studies on normal and disease models (e.g., neonatal stroke) during mammalian development.

PI_NAMEs: ROWE, MANOEL  (contact);ZAYACHKIVSKY, ANDREW

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: Adult;Affect;Animal Behavior;animal care;Animal Experiments;Animal Model;Animal Welfare;Animals;Back;Basic Science;Behavioral;Biomedical Research;Body Temperature;Brain;Brain Injuries;Butyric Acids;Caring;Cells;Characteristics;Childhood;Clinical;cold temperature;Collaborations;commercialization;Computer software;Confounding Factors (Epidemiology);Coupling;Data;data acquisition;Data Analyses;data exchange;design;design,build,test;Development;Devices;Disease;disease model;Dropout;drug discovery;Electrocardiogram;Electroencephalography;Engineering;Environment;Equipment;Event;experience;experimental study;Humidity;Implant;improved;Individual;Intellectual Property;Intervention;invention;Legal patent;manufacture;Membrane;Modeling;Monitor;Morphologic artifacts;Movement;Mus;natural hypothermia;Neonatal;neonatal stroke;neonate;Nervous System Disorder;Nervous System Trauma;neuroprotection;Neurosciences;Neurotransmitters;novel;Organism;Pharmacological Treatment;Phase;Physiologic Monitoring;Physiological;Play;Positioning Attribute;preclinical study;programs;prototype;pup;Rattus;Reproducibility;Research;Research Design;Research Personnel;Research Subjects;Resolution;response;Rodent;Rodent Model;Seizures;Signal Transduction;Small Business Innovation Research Grant;standard care;Stream;System;systems research;Technology;Telemetry;Temperature;Testing;Time;tool;Translational Research;transmission process;two-dimensional;Universities;Utah;Weaning;Weight;wireless;wireless transmission;Work

PROJECT_TITLE: Temperature-Controlled Recording System for Wireless Data Acquisition from Immature Rodents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-C(10)B]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences;Substance Misuse

ORG_CITY: SYDNEY

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF SYDNEY

PHR: Project Narrative The NSW Brain Tissue Resource Center provides well-characterized, high quality central nervous system tissues, associated clinical and lifestyle information and other data to researchers worldwide. Human post-mortem brain tissue is a proven and essential resource for studying the cellular and molecular basis of addiction and alcohol-related brain damage. In addition, human tissue and data- based studies augment clinical and preclinical studies to identify novel therapeutic targets for persons living with alcohol use disorder.

PI_NAMEs: SUTHERLAND, GREG TREVOR (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: addiction;Address;Advocacy;Aging;aging brain;Alcohol consumption;alcohol misuse;alcohol research;alcohol use disorder;Alcohols;Autopsy;biobank;Biological Markers;Biological Models;Blood;Brain;Brain Injuries;brain tissue;Cardiovascular Diseases;career;Central Nervous System;Cessation of life;chronic alcohol ingestion;cigarette smoking;Classification;Clinical;Clinical Research;cohort;Collaborations;Collection;Communities;comorbidity;Consent;Data;Diagnosis;Disease;Dissection;DNA;DNA analysis;drinking;DSM-V;Ensure;Event;Exclusion Criteria;experience;Experimental Designs;Family;Forensic Medicine;Formalin;Freezing;Functional disorder;Genetic;genomic data;Genotype;Goals;Guidelines;health economics;Heavy Drinking;Hospital Records;Human;human data;human tissue;illicit drug use;improved;inclusion criteria;Individual;Institutional Ethics;Interview;Knowledge;Laboratories;Life Style;Lived experience;Liver diseases;Medical;Medical Records;Medical Research;Mental disorders;Mental Health;Methods;mid-career faculty;Molecular;National Institute on Alcohol Abuse and Alcoholism;Nervous System Disorder;Neuroanatomy;Neurobiology;neurocognitive test;neuroimaging;neuropathology;new therapeutic target;next generation;operation;Organ;Paraffin Embedding;Pathologist;Patient Self-Report;Persons;polysubstance abuse;precision medicine;preclinical study;Preparation;programs;prospective;Protocols documentation;psychiatric comorbidity;Public Health;Publications;Questionnaires;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Research Technics;Resources;sample collection;Sampling;SARS-CoV-2 infection;Scientist;screening;Services;social media;socioeconomics;sound;Specialist;Specimen;Stains;Substance Use Disorder;symposium;Techniques;Testing;Time;Tissue Fixation;tissue preparation;tissue resource;Tissues;tool development;transcriptomics;Universities;Update;volunteer;Work

PROJECT_TITLE: Brain Tissue Resource Center for Alcohol Research

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Data Science;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative Alleviating the burden of neurological and psychiatric disorders will require a cohort of investigators who  can use computational and theoretical tools to understand brain function in health and disease. This  program will train undergraduates and graduate students to use quantitative modeling combined with  advanced statistical and machine learning methods for analysis of large datasets to reveal features of  brain function and disease not possible without these quantitative approaches.

PI_NAMEs: MILLER, PAUL  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Attitude;Behavior;Biology;career;Cognition;Collaborations;computational neuroscience;computer science;Computing Methodologies;Coupled;Data;Data Analyses;design;Disease;doctoral student;Eligibility Determination;Ensure;experience;Faculty;Funding;Goals;graduate student;Health;Human;Individual;Institution;interdisciplinary collaboration;Knowledge;laboratory experience;Laboratory Research;Learning;Machine Learning;mathematical model;Mathematics;Mentors;Methods;model building;Molecular;National Institute of Drug Abuse;National Research Service Awards;Nervous System;Neurons;Neurosciences;outreach;pre-doctoral;programs;Prospective cohort;Psychology;Research;Research Project Grants;Science;Scientist;Senior Scientist;skills;statistics;Students;Synapses;Teacher Professional Development;Training;Training Programs;undergraduate student;Underrepresented Populations;Universities;Work;Writing

PROJECT_TITLE: Undergraduate and Graduate Training in Computational Neuroscience and Data Analysis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: San Diego

ORG_NAME: CORTECHS LABS, INC.

PHR: Project Narrative The purpose of this project is to develop a clinical diffusion image analysis software which will automatically calculate diffusion imaging-based biomarkers for early Alzheimer’s disease diagnosis, better patient management and potentially monitor the effects of the therapeutic interventions. We will either use diffusion tensor images or if available multi-shell diffusion images in conjunction with volumetric MRI images for segmentation and then report microstructural parameters from these segmented brain regions. These microstructural parameters or diffusion biomarkers will then be used for separating AD patients from controls and monitoring treatment response during pharmaceutical interventions.

PI_NAMEs: ULUG, AZIZ M (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Affect;Age;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid beta-Protein;Anatomy;Axon;bioimaging;Biological Markers;Brain;Brain region;Classification;Clinical;Cognitive;Computer software;Cox Proportional Hazards Models;Data;Databases;Dendrites;density;Deposition;Diagnosis;Diffusion;diffusion anisotropy;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;early detection biomarkers;Early Diagnosis;Future;Gender;Goals;gray matter;Image;Image Analysis;imaging biomarker;imaging modality;imaging Segmentation;Imaging Techniques;Impaired cognition;in vivo;indexing;Individual;Intervention;intervention effect;Location;Logistic Regressions;Magnetic Resonance Imaging;manufacture;Maps;Measures;Methods;mild cognitive impairment;Modeling;Monitor;Neurites;Neurofibrillary Tangles;neuron loss;Neurons;neuropathology;Pathologic;Pathology;Pathway interactions;Patients;Performance;Pharmacologic Substance;Phase;Population;Positron-Emission Tomography;predictive modeling;Process;Prognosis;Qualifying;Reporting;Restriction Spectrum Imaging;Scanning;structural imaging;Structure;tau Proteins;Techniques;Therapeutic Effect;tool;Training;treatment response;white matter

PROJECT_TITLE: Quantifying microstructural changes in Alzheimer's disease using Restriction Spectrum Imaging