NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: ANN ARBOR

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: DIVERSITY SUPPLEMENT PROJECT NARRATIVE Sexual minority young adults are at elevated risk for alcohol use and alcohol misuse. High quantity and frequent alcohol use and alcohol misuse are robustly associated with increased oxidative stress, and these alcohol- biology associations are strong predictors of various physical and psychological health conditions and substantially contribute to mortality. The proposed work for this supplement seeks to evaluate the adverse health consequences of alcohol use and alcohol misuse on oxidative stress among sexual minority young adults across sociodemographic subgroups who are known to vary in elevated risk for alcohol use and alcohol misuse but are under-represented in biological studies of health disparities.

PI_NAMEs: EVANS-POLCE, REBECCA J. (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Address;Adolescent;Adult;Age;alcohol consequences;Alcohol consumption;alcohol measurement;alcohol misuse;alcohol risk;alcohol use disorder;Alcohols;Behavior;binge drinking;Biological;Biological Process;Biology;Cannabis;career;Caring;Characteristics;Complement;cost;COVID-19;Criminal Justice;Data;Dimensions;Discrimination;Distal;Engineering;ethnic identity;Ethnic Origin;falls;fluidity;Frequencies;Funding;Gender Identity;gender minority group;gender minority health disparity;Goals;Grant;Growth;Health;health data;health determinants;health disparity;Healthcare;Heterogeneity;Heterosexuals;improved;Individual;interest;Isoprostanes;Knowledge;Laws;Lesbian Gay Bisexual;Link;Liquid substance;longitudinal design;Longitudinal Studies;Measures;Medicine;Mental Health;Mentorship;Methodology;minority stressor;Modeling;mortality;Movement;Outcome;Oxidative Stress;parent grant;Patient Self-Report;Pattern;Pharmaceutical Preparations;physical conditioning;Policies;polysubstance use;Population Assessment of Tobacco and Health;population based;Positioning Attribute;Problem behavior;Process;Productivity;prospective;protective factors;Public Policy;public policy on alcohol;Race;racial identity;Reporting;Research;Research Design;Research Project Grants;response;Risk;Risk Factors;Sampling;secondary analysis;Severities;sex;Sex Orientation;Sexual and Gender Minorities;sexual identity;sexual minority;sexual minority group;sexual minority health;sexual minority women;Shapes;skills;social;Social Interaction;sociodemographics;Socioeconomic Status;Stress;stressor;Subgroup;Substance Use Disorder;Symptoms;Testing;Time;Tobacco;Training;United States National Academy of Sciences;United States National Institutes of Health;Variant;Work;Writing;young adult;Youth

PROJECT_TITLE: Alcohol misuse and oxidative stress among diverse sexual minority young adults


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: JACKSON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: PROJECT NARRATIVE The impetus for the ComPASS Program is the increasing recognition that advancing health equity is a complex challenge that extends beyond the reach of traditional healthcare settings, organizations, or research agendas. This NIH-wide program was created to foster efforts to address structural causes and pathways of differential health outcomes, with the goal of reducing health disparities across diseases and conditions among populations that experience them. The proposed SEACHANGE Hub would participate as one of five hubs in a program that also includes 25 Community-led, Health Equity Structural Intervention (CHESI) projects throughout the U.S. and one Coordinating Center.

PI_NAMEs: COMPRETTA, CAROLINE E. (contact)

PROGRAM_OFFICER_NAME: ACEVEDO, AMANDA MARIE

PROJECT_TERMS: Achievement;Address;Alabama;Arkansas;burden of illness;Clinic;Collaborations;college;Communities;community advisory board;community building;community engaged approach;community engagement;Community of Practice;Community Outreach;Community-Led Health Equity Structural Intervention;Complex;Continuing Education;Country;Data Collection;Data Element;data harmonization;data management;data quality;design;Development;Disease;dissemination strategy;Doctor of Philosophy;Educational Curriculum;Elements;Ensure;Equity;Evaluation;experience;Faculty;Fostering;Goals;Growth;Health;health care settings;health equity;health equity promotion;Health equity research;implementation intervention;implicit bias;Information Dissemination;Institution;Intervention;Intervention Studies;Knowledge;Laws;Learning;learning community;Louisiana;Measures;Medical center;member;Mentorship;Methods;minority health;Mission;Mississippi;Modeling;Monitor;multidisciplinary;Needs Assessment;Outcome;participant retention;Pathway interactions;Patient Recruitments;peer;Policy Analysis;Population;Poverty;Program Evaluation;programs;Reduce health disparities;Research;research data dissemination;Research Design;Research Methodology;Research Project Grants;Research Support;Resource Development;Resources;Scholars Program;Security;Services;social;social health determinants;Structural Racism;success;Training;Training Support;Underserved Population;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Southeast Center for Health Achievement and Growth in Equity (SEACHANGE) Hub

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-P (52)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: NARRATIVE – OVERALL PPG  Addiction remains one of the world’s greatest public health problems, yet its pathophysiology remains incompletely understood and available treatments for addictions to various drugs of abuse are inadequately effective for most people. This new Program Project Grant, focused on mechanisms of transcriptional and chromatin regulation on a cell type-specific basis, will contribute to a better understanding of the neurobiological basis of addiction, which we believe is necessary for the eventual development of definitive treatments and cures for substance use disorders.

PI_NAMEs: NESTLER, ERIC J. (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Animal Model;Animals;Autopsy;Back;Behavioral;Bioinformatics;Biology;Brain;Brain region;brain reward regions;brain tissue;cell type;Chromatin;chromatin modification;circular RNA;Collaborations;complex data;Corpus striatum structure;Data Set;Development;Dorsal;Drug Addiction;drug of abuse;Enhancers;Functional disorder;Gene Expression Regulation;Gene Transfer;Genes;Genetic Transcription;genome-wide;Human;Individual;interest;Investigation;Knowledge;Link;Mediator;Methods;Microglia;Molecular;multidisciplinary;Mutant Strains Mice;Neurobiology;Neurons;novel;Nucleus Accumbens;operation;Opiate Addiction;Opioid;Persons;Play;Prefrontal Cortex;Program Research Project Grants;Public Health;Recording of previous events;Regulation;Research;response;Rewards;Role;Self Administration;Stimulant;stimulant dependence;Substance Use Disorder;Synapses;tool;transcription factor;Transcriptional Regulation;Untranslated RNA;Viral Genes;Work;Yasmin

PROJECT_TITLE: Transcriptional Mechanisms of Drug Addiction


FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Fentanyl Misuse and Addiction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Neurosciences;Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Recovery Support Services;Rehabilitation;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: ANCHORAGE

ORG_NAME: SOUTHCENTRAL FOUNDATION

ORG_STATE: AK

PI_NAMEs: MICHLIG, GEORGIA J;SHANE, ALIASSA  (contact);TRINIDAD, SUSAN BROWN

PROGRAM_OFFICER_NAME: SMITH, JACLYN D'ANNE

PROJECT_TERMS: Acculturation;addiction;Address;Adult;Affect;Alaska;Alaska Native;Alaskan;Alcohol consumption;alcohol-related death;Alcoholic Liver Diseases;Alcohols;American Indian community;American Indian Population;American Indians;Anxiety;Area;Attention deficit hyperactivity disorder;Awareness;Behavior Therapy;behavioral health;beneficiary;care outcomes;Caregivers;Caring;Cessation of life;Child;Climate;Cocaine;Collaborations;Communities;community based treatment;Community Health;Complex;Coping Skills;cost;COVID-19 pandemic;criminal behavior;Death Rate;design;Development;Distant;effective therapy;Emotional;Environment;Evidence based treatment;experience;Exposure to;Family;Family member;federal policy;Fentanyl;fentanyl overdose;Focus Groups;Foundations;Friends;Future;General Population;Generations;Geography;Goals;Health;health care availability;health care service organization;Health Services Accessibility;Health system;Healthcare Systems;Heroin;holistic approach;Home;Homelessness;Hospitalization;Improve Access;improved;Indigenous;Individual;Infrastructure;Inpatients;Intention;interest;Interview;Knowledge;Language;Leadership;Learning;Literature;low socioeconomic status;Manuscripts;Marijuana;medication for opioid use disorder;meetings;Mental Depression;Mental disorders;Mental Health;Mentors;Mentorship;methamphetamine use;Methods;Modality;Needs Assessment;Opioid;opioid use;Outcome;outpatient programs;Overdose;overdose death;pandemic disease;Participant;Patients;peer coaching;peer support;Performance;Persons;Pharmaceutical Preparations;phase 2 study;Play;Policies;Population Density;Preparation;Prevalence;prevent;Prevention;programs;Provider;Psychological reinforcement;Public Health;public health emergency;Qualitative Methods;Race;Recommendation;Recording of previous events;Recovery;recovery services;Recovery Support;Relationship-Building;Reporting;Research;Research Methodology;Research Personnel;Resources;Risk Factors;Rural;Rural Community;rural health clinic;Schools;service utilization;Services;skills;Social isolation;Social Network;Social support;Specific qualifier value;Spirituality;substance misuse;substance use;Substance Use Disorder;substance use treatment;Suicide attempt;Suicide prevention;Support System;Surveys;symposium;Telemedicine;Time;Tobacco;Training;Travel;treatment program;treatment services;tribal health;tribal leader;tribal Nation;Tribes;Trinidad;Well in self;Work

PROJECT_TITLE: Commitment to Recovery: Alaska Native Community Needs for Substance Use Treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 OTHR-6 (01)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: OVERVIEW: PROJECT NARRATIVE Despite a strong evidence base for diabetes prevention and care, significant gaps remain in equitably translating these research findings into real life policy and practice; the overall burdens and costs continue to grow rapidly, with the minorities and socioeconomically disadvantaged groups in the Southeastern U.S. disproportionately affected. To address these gaps, we propose the Georgia Center for Diabetes Translation Research (GCDTR) with the vision of promoting equity through high-quality translation research and a culture of evidence based decision-making across academic, health system, community, and local government partners in Georgia, Florida, and Tennessee. GCDTR will serve as a platform to increase investigator capacity, share expertise, and generate and disseminate knowledge to influence practice and policy to improve diabetes outcomes and health equity.

PI_NAMEs: NARAYAN, KABAYAM M VENKAT (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adoption;Affect;Award;base;Behavior;Behavioral;Behavioral Sciences;Businesses;Cardiovascular Diseases;career;Caring;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Sciences;cohesion;Collaborations;Communities;community engaged research;community setting;comorbidity;cost;Country;COVID-19;Data;Decision Making;design;diabetes management;Diabetes Mellitus;Diabetes prevention;diabetes risk;Discipline of Nursing;Disparity population;econometrics;economic cost;economic disparity;Economically Deprived Population;Economics;Effectiveness;Emerging Technologies;Engineering;Equity;ethnic disparity;Ethnic Origin;Ethnic Population;Evaluation;evidence base;experience;Faculty;Failure;Florida;Funding;Future;Geography;Government;Grant;Health;health disparity;health disparity populations;health equity;health equity promotion;Health equity research;Health Promotion;Health Sciences;Health system;high risk;HIV;Home;improved;Income Tax;innovation;Institution;Intervention;K-Series Research Career Programs;Knowledge;knowledge translation;Leadership;Learning;Life;Local Government;Maintenance;Measurement;medical schools;Medicine;member;Mental Depression;Metabolic;Methodology;Minority;Modeling;Morehouse School of Medicine;multidisciplinary;next generation;Non-Insulin-Dependent Diabetes Mellitus;older adult;Outcome;pharmacologic;Policies;Population Heterogeneity;Postdoctoral Fellow;prevent;Prevention;programs;Public Health Schools;racial minority;racial minority population;recruit;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Rural;School Nursing;Schools;Science;Services;social;social disparities;Social Policies;socioeconomic disadvantage;socioeconomics;Sorting;Subgroup;success;Talents;Technology;Tennessee;Translating;translational health science;Translational Research;translational scientist;Translations;underserved area;Underserved Population;United States National Institutes of Health;Universities;Vision;Vulnerable Populations;Work

PROJECT_TITLE: Econometric Evaluation of Earned Income Tax Credit Expansions on Type 2 Diabetes-Related Behavior and Outcomes: Identifying effective leverage opportunities in social policy changes for health equity


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Nanotechnology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Relevance to Public Health In this proposal, we will test a new technology, called HRT, that will allow for substantial reduction in the amount of therapy needed to safely and effectively treat cardiomyopathy. We will also test whether HRT works particularly well in the hearts of mice with Friedreich’s ataxia (FA). This technology will allow us to create a safer gene therapy for FA patients and potentially eliminate heart deterioration and improve lifespan.

PI_NAMEs: MAISEYEU, ANDREI  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Adjuvant;Adult;Antibodies;Antisense Oligonucleotides;Apoptosis;autosome;Benefits and Risks;Biodistribution;Biological Markers;Blood;Body Weight;Capsid;Cardiac;Cardiac Myocytes;Cardiac Output;Cardiomyopathies;Cause of Death;Cell model;Cell Therapy;Cells;chemical conjugate;Chronic;Clinical;clinical translation;Clinical Trials;Compensation;complement system;cytokine;Data;delivery vehicle;Deposition;Disease;Dose;driving force;Drug Delivery Systems;Echocardiography;Engineering;Enhancers;enhancing factor;Enzymes;Epitopes;experimental study;Fibrosis;frataxin;Frequencies;Friedreich Ataxia;gene therapy;Genes;Genetic;genetic information;Glucose;glucose uptake;glycosylation;Heart;Heart Diseases;Heart failure;Hepatocyte;Histopathology;Human;human induced pluripotent stem cells;Hypertrophic Cardiomyopathy;Hypertrophy;IgE;Immune response;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunoglobulins;improved;induced pluripotent stem cell;Inflammation;Injectable;Injections;Insulin Receptor;Investigational Drugs;Kupffer Cells;Laboratories;Lactic acid;Latex;Lead;Life;life span;Liposomes;Liver;Macrophage;Measures;Mesenchymal Stem Cells;Minor;Modality;Modeling;Modification;molecular marker;Monoclonal Antibodies;mortality;mouse model;Mus;Mutation;Myocardial Degeneration;Myocardium;nanoparticle;Necrosis;new technology;Nucleic Acids;Oligonucleotides;Organ;overexpression;Overweight;participant enrollment;Patients;Pharmaceutical Preparations;Pharmacotherapy;Plasma;Polymers;Positron-Emission Tomography;premature;Protein Engineering;Proteins;Public Health;Reproducibility;Safety;safety testing;side effect;small molecule;stem cells;Surface;System;targeted delivery;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Agents;Therapeutic Index;therapeutic target;Time;Transgenes;Treatment Efficacy;Tropism;uptake;vector;Viral;Viral Genes;Viral Vector;Virus;Work

PROJECT_TITLE: Engineered polymeric adjuvants for heart-redirected targeting and gene therapy

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The number of older adults involved in the criminal legal system (“justice-involved older adults”) has risen dramatically in recent decades, resulting in a growing population of older adults with profound, often co- occurring social and medical vulnerabilities and high rates of health disparities. We launched the ARCH (Aging Research in Criminal Justice Health) Network in 2019 a nationwide, multi-disciplinary community of emerging and established researchers, to catalyze research and interventions designed to improve health and social outcomes in the growing population of criminal justice-involved older adults. This proposal will further develop and sustain The ARCH Network to support emerging and established investigators to advance the conduct and dissemination of research on the health and social drivers of criminal legal system involvement and its consequences on health in later life and to accelerate the translation of this research into practice and policy that can care for this population.

PI_NAMEs: BARRY, LISA C;WILLIAMS, BRIE A (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Acceleration;Address;Aging;aging population;American;Area;Arkansas;Award;Behavioral;black men;Black race;California;career;Caring;Collaborations;Color;Communities;Community Healthcare;Country;court;Criminal Justice;Criminology;disability;Discipline;Discipline of Nursing;Drug Legislation;early onset;education research;Elderly;Ensure;Ethics;Evidence based intervention;experience;Extramural Activities;Faculty;Funding;Future;Geography;Geriatrics;graduate student;Grant;Growth;Health;Health Disparities Research;health disparity;Healthcare;Healthcare Systems;Homelessness;Imprisonment;improved;Individual;Institution;Interdisciplinary Study;Intervention;Investments;Jail;Journals;Justice;K-Series Research Career Programs;Knowledge;late life;Latino;Laws;Leadership;Legal system;Life Cycle Stages;life span;lifetime risk;Manuscripts;Medical;medical vulnerability;Medicine;meetings;member;men;Mental Health;Mentors;Mentorship;Methodology;multidisciplinary;next generation;older adult;Older Population;Onset of illness;Palliative Care;parole;Persons;Police;Policies;Population;Population Intervention;Prisons;probation;Psychology;Public Health;public health research;Publishing;racial bias;Reduce health disparities;Research;Research Design;Research Personnel;Research Support;research to practice;Risk Factors;San Francisco;Scholarship;Science;Scientist;Series;social;social health determinants;Social outcome;social vulnerability;Social Work;Substance Use Disorder;success;symposium;Testing;therapy design;Training;Translational Research;Translations;Trauma;United States National Institutes of Health;Universities

PROJECT_TITLE: Advancing Health Disparities Research in Aging: The Aging Research in Criminal Justice & Health (ARCH) Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M2)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative Cancer is the leading cause of death in an increasingly aged population in the United States. Personalized medicine based on patient-specific, disease-state relevant dynamic information holds great promise in revolutionizing the standard of care for cancer. Using acute myeloid leukemia as a proof-of-concept, the goal of this research is to develop and apply state-transition based mathematical modeling to predict individual therapy response and to design adaptive therapeutic approaches to ultimately advance personalized medicine.

PI_NAMEs: KUO, YA-HUEI ;MARCUCCI, GUIDO ;ROCKNE, RUSSELL CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: 1q22;Acceleration;Accounting;Acute Myelocytic Leukemia;aging population;Allogenic;BCL1 Oncogene;bcr-abl Fusion Proteins;Biological;Biological Markers;Blood;cancer care;Cause of Death;CBFbeta-MYH11 fusion protein;Cells;chemotherapy;Chronic Myeloid Leukemia;Clinic;Clinical;Clinical Data;Clinical Trials Design;Combined Modality Therapy;Cytogenetics;Data;Death Rate;design;Development;Disease;Dose;drug maintenance;Drug resistance;Event;Evolution;FLT3 gene;fusion gene;Future;Genetic;Genetic Models;Geometry;Goals;Health;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Human;Immune;improved outcome;Individual;individualized medicine;inhibitor;Knock-in;Knock-in Mouse;leukemia;leukemia treatment;leukemic stem cell;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mathematical Computing;mathematical model;Mathematics;Measurement;MicroRNAs;Modeling;Molecular;molecular subtypes;Monitor;mouse model;Movement;Mus;Mutation;neoplastic cell;novel;novel diagnostics;novel therapeutic intervention;Oncogenes;Oncogenic;optimal treatments;Outcome;Patients;personalized medicine;Population;Prediction of Response to Therapy;predictive modeling;Prognostic Factor;Recurrent disease;Reporting;Research;Resistance;response;self-renewal;Series;Signal Transduction;simulation;Source;standard of care;stem cell population;Survival Rate;Testing;Therapeutic;therapy design;therapy resistant;Time;time use;transcriptome;transcriptome sequencing;Translating;treatment effect;treatment optimization;treatment response;United States;Work

PROJECT_TITLE: State-transition and leukemia potential dynamics to inform disease evolution and adaptive therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (M1)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Complementary and Integrative Health;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: PEMBROKE

ORG_NAME: LUMBEE LAND DEVELOPMENT, INC.

ORG_STATE: NC

PI_NAMEs: BEASLEY, CHERRY M. (contact);BELL, RONNY A;IRBY, MEGAN ;PENZIEN, DONALD BAIRD

PROGRAM_OFFICER_NAME: HAFNER, STEVEN PAUL

PROJECT_TERMS: Accidental Injury;Action Research;Acute Disease;Acute Pain;addiction;Address;Adult;Advisory Committees;Ally;American Indian Population;American Indian Tribe;American Indians;Area;Automobile Driving;Award;Case Management;Certification;Cessation of life;Cherokee Indian;Chronic Disease;chronic pain;Cognitive;Collaborations;Communities;community academic partnership;community advisory board;community based participatory research;community based research;community engaged intervention;community engagement;Community Health Aides;community organizations;Consult;Coping Skills;Counseling;County;COVID-19 testing;COVID-19 vaccination;culturally appropriate intervention;dashboard;Data;Data Analyses;data dashboard;data sharing;Death Rate;design;Development;Diagnosis;Disasters;Disparity;Drug usage;Education;Educational Intervention;Elements;Emergency department visit;Enrollment;Ensure;Epidemic;epidemic response;Epidemiologist;Epidemiology;Ethnic Population;Evaluation;evidence base;Evidence based intervention;Exercise;experience;family support;fentanyl overdose;Focus Groups;Formulation;Funding;Future;Goals;Guidelines;Harm Reduction;harm reduction programs;healing;Health;health assessment;health care availability;health disparity;Health Professional;Health Services;Healthcare;Helping to End Addiction Long-term;Hepatitis C;heroin overdose;Hospitalization;Hot Spot;Human;Hurricane;improved;Indigenous;indigenous community;Indigenous Medicine;Injury;injury prevention;Institution;Intentional injury;International;Intervention;Kinship Networks;Lumbee tribe;marginalization;medication-assisted treatment;meetings;member;Mental Health;Modality;Modeling;multidisciplinary;North Carolina;Opiate Addiction;opioid misuse;opioid overdose;opioid use disorder;Outcome;outreach;Overdose;Ownership;Pain;Pain management;Participant;Pathway interactions;Patients;peer support;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacy Schools;pilot test;Policies;Policy Developments;Population;Positioning Attribute;Poverty;Prevention;Prevention Research;Privatization;Process;professor;programs;Protocols documentation;Public Health;Publishing;racial population;Recommendation;Records;Recovery;Reporting;Research;research and development;Research Infrastructure;Research Personnel;Research Training;resilience;Resources;Rural;rural counties;Science;Scotland;Services;social;social health determinants;Social Work;Speed;stimulant use disorder;substance misuse;substance misuse prevention;substance use;symposium;Testing;Training;Trauma;tribal community;tribal health;tribal leader;tribal member;tribal Nation;tribal organization;Tribes;United States;United States Indian Health Service;United States National Institutes of Health;Universities;urban Native American;Validation;violence prevention;web site;Wellness Program;Work;Youth

PROJECT_TITLE: Building iCRISP: Indigenous Community-Informed Research Infrastructure to address Substance Misuse and Pain Management


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke;Telehealth

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Parent Grant: R01MD016465– Video-based Intervention to Reduce Treatment and Outcome Disparities in Adults Living with Stroke or Transient Ischemic Attack (VIRTUAL) Principal Investigator: Anjail Z. Sharrief, MD, MPH Type of Administrative Supplement: Diversity Level of Supplement Requested: Investigator Proposed Period of Support: February 1, 2024-January 31, 2026 A. PROJECT NARRATIVE The proposed research supplement will improve our understanding of barriers and facilitators to the use of telemedicine among a group of racially, ethnically, economically, and geographically diverse population of stroke survivors. In addition, it will improve our understanding of the relationship between digital health literacy and a variety of process, clinical, and patient reported outcomes. This information will lay the foundation for further research and development of interventions aimed at increasing the utilization of telehealth services in stroke survivors which may improve stroke disparities.

PI_NAMEs: SHARRIEF, ANJAIL Z (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Administrative Supplement;Adult;Ambulatory Blood Pressure Monitoring;Ambulatory Care;Black race;Blood Pressure;blood pressure control;blood pressure reduction;Blood Vessels;Brain hemorrhage;Caring;Cessation of life;Clinical;comparative effectiveness trial;Coronary;COVID-19 pandemic;Data;digital health;Discrimination;Disparity;disparity reduction;Effectiveness;Enrollment;Ethnic Origin;Event;experience;follow-up;food insecurity;Foundations;Funding;Geography;health care service utilization;health literacy;Health Services;Health Services Accessibility;Healthcare;Heart failure;Heterogeneity;Hispanic;Home;hospital readmission;Hospitalization;Hospitals;Hour;Hypertension;Improve Access;improved;indexing;Inpatients;Insurance;Insurance Coverage;interdisciplinary approach;Intervention;intervention effect;Ischemic Stroke;Language;Medicaid;Modeling;multidisciplinary;Myocardial Infarction;Neighborhoods;Neurologist;Neurology;Nurse Practitioners;Outcome;outcome disparities;parent grant;Patient Outcomes Assessments;Pharmacists;Physicians;Population Heterogeneity;post intervention;post stroke;predictive modeling;primary care provider;primary outcome;Principal Investigator;Process;programs;Provider;Race;racial disparity;racial population;racism;Randomized;randomized trial;Recurrence;Research;research and development;Research Personnel;revascularization;Risk;Risk Assessment;Risk Factors;segregation;social;social health determinants;Social support;social vulnerability;Social Workers;standard care;Stroke;stroke risk;stroke survivor;Survivors;System;telehealth;Telemedicine;telemonitoring;Testing;therapy development;Transient Ischemic Attack;treatment and outcome;Uninsured;United States;urgent care;Visit

PROJECT_TITLE: Video-based Intervention to Reduce Treatment and OUtcome Disparities in Adults Living with Stroke or Transient Ischemic Attack (VIRTUAL)

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis

PHR: PROJECT NARRATIVE We recently identified a novel population of fibroblasts that emerge in response to lung injury. This grant will explore the signals that induce these fibroblasts and the pathways by which inflammatory fibroblasts modulate lung inflammation and fibrosis.

PI_NAMEs: SHEPPARD, DEAN  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Aftercare;Alveolar;Bleomycin;Cells;Chronic;Color;CRISPR/Cas technology;Data;Development;Epithelial Cells;Extracellular Matrix Proteins;Fibroblasts;Fibrosis;fibrotic lung disease;gain of function;Genes;Genetic;genetic manipulation;Grant;Human;I-kappa B Proteins;idiopathic pulmonary fibrosis;Immune;Immunohistochemistry;In Situ Hybridization;Inflammation;Inflammation Mediators;Inflammatory;inflammatory modulation;Inflammatory Response;inhibitor;Injury;insight;loss of function;Lung;lung injury;Lung Transplantation;Macrophage;Mechanics;Mediating;Modeling;Molecular;molecular phenotype;Mus;NF-kappa B;novel;novel therapeutic intervention;Ontology;Pathway interactions;Patients;pharmacologic;Piezo 2 ion channel;Population;prevent;profibrotic fibroblast;Progressive Disease;Pulmonary Fibrosis;Pulmonary Inflammation;recruit;Resolution;response;Rest;Role;Scleroderma;sensor;Signal Induction;Signal Transduction;Silicon Dioxide;single-cell RNA sequencing;Spatial Distribution;Stimulus;Time;Tissues;TNF gene;tool;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;treatment strategy

PROJECT_TITLE: Induction, fate and function of inflammatory fibroblasts

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project narrative Bacteria contain proteins that pump out antibiotics. During antibiotic treatment, nearly one-third of bacteria involved in infections increase the number of pumps to gain antibiotic resistance. We aim to understand how these pumps work by looking at them directly in the bacteria using state-of-the-art cryo-electron microscopy. If we can understand how they assemble and what they look like, we hope to help design new drugs to block the pumps and prevent antibiotic resistance.

PI_NAMEs: WANG, ZHAO  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Affect;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Automobile Driving;Bacteria;beta barrel;Binding;Biochemical;cell envelope;Cell Wall;Cells;Cellular Membrane;Clinical;Clinical Trials;clinically relevant;combat;Complex;Computing Methodologies;Cryo-electron tomography;Cryoelectron Microscopy;Cytoplasm;Data;design;Diameter;Docking;Drug Efflux;Drug resistance;efflux pump;Environment;Equilibrium;Escherichia coli;Escherichia coli drug resistance;Escherichia coli K12;experimental study;Fluoroquinolones;Genes;Genetic;Goals;Gram-Negative Bacteria;imaging approach;In Situ;Infection;inhibitor;insight;Knock-out;Laboratories;Ligand Binding;Ligands;Membrane;Membrane Potentials;minimal inhibitory concentration;Molecular;molecular assembly/self assembly;Molecular Conformation;Multi-Drug Resistance;multidisciplinary;novel therapeutics;pathogenic bacteria;pathogenic Escherichia coli;Pathogenicity;Pathway interactions;periplasm;Pharmaceutical Preparations;Play;Preparation;prevent;Process;Production;Proteins;Protocols documentation;Protomer;Proton-Motive Force;Protons;Pump;Research;Resolution;response;Role;Specimen;Structure;System;Techniques;Therapeutic;Thinness;tomography;Uncoupling Agents;Virulence;Visualization;Work

PROJECT_TITLE: Molecular Assembly of Bacterial Tripartite Multidrug Efflux Pumps

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Genetics;Heart Disease;Mental Health;Neurosciences

ORG_NAME: GEORGIA STATE UNIVERSITY

PHR: Project Narrative Stressful life events contribute to the onset of cardiovascular disease, which is the leading cause of death in the United States. This project investigates whether the activity of neurons residing within discrete portions of the nervous system promotes resiliency or susceptibility to stress. Completion of the research may guide the development of novel therapeutics that relieve stress and alleviate cardiovascular disease.

PI_NAMEs: KRAUSE, ERIC GERALD (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Angiotensin Receptor;Angiotensin Type 1a Receptor;Angiotensins;anxiety-like behavior;Attenuated;behavioral response;Blood Pressure;blood pressure reduction;Brain region;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Cause of Death;Corticosterone;Coupled;Cre lox recombination system;Development;Disease;Energy Metabolism;Etiology;experimental study;Functional disorder;Gene Modified;Gene Transfer;Genes;Genetic;genetic technology;Heart Rate;Human;improved;in vivo;indexing;insight;Intervention;Laboratory mice;Link;Mediating;Modeling;Modernization;Mus;Nervous System;neural;neural circuit;neural patterning;neuronal excitability;Neurons;Neurosciences;Neurosecretory Systems;Nodose Ganglion;novel therapeutics;optogenetics;perceived stress;Perception;pharmacologic;Physiology;Population;preclinical study;Predisposition;Pressoreceptors;promote resilience;Psychological Stress;receptor;Research;Stress;Stressful Event;Structure;System;Techniques;therapeutically effective;United States;Viral

PROJECT_TITLE: Interrogating stress-relieving neural circuits to alleviate cardiovascular disease


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Relevance to Public Health: Defect in trophoblast lineage development results in early pregnancy loss or leads to pregnancies that are associated with pre-term birth, intrauterine growth restriction and preeclampsia, which cause serious adverse effects on maternal and infant health. These are major public health concerns. Therefore, a better understanding of trophoblast cell lineage development and function is critical to gain insights into important features of pregnancy loss and pregnancy associated disorders.

PI_NAMEs: PAUL, SOUMEN  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Adult;Adverse effects;Affect;Biology;Blood Vessels;Cell Lineage;Cells;conditional knockout;cytotrophoblast;Defect;Development;Diagnosis;Disease;early onset;early pregnancy loss;Embryo;Embryonic Development;Ensure;epitranscriptomics;Equilibrium;Experimental Models;experimental study;fetal;Fetal Development;Fetal Growth Retardation;Fetal health;Functional disorder;Gases;gene conservation;Gene Expression;genetic signature;Genetic study;Genetic Transcription;Goals;Hormones;Human;Impairment;implantation;Infant Health;insight;Invaded;Knock-out;knockout gene;Knockout Mice;loss of function;Maintenance;Maternal Health;Mediating;Methyltransferase;MicroRNAs;Modification;Molecular;Mothers;mouse model;mRNA Decay;mRNA Precursor;Mus;mutant mouse model;natural Blastocyst Implantation;Nuclear Export;Nutrient;overexpression;Pathologic;Placenta;Placentation;postnatal;Pre-Eclampsia;Pregnancy;pregnancy disorder;Pregnancy loss;Premature Birth;Process;programs;Public Health;Regulation;Research;RNA;RNA Splicing;Role;self-renewal;stem;stem cell self renewal;stem cells;Syncytiotrophoblast;Testing;Translational Regulation;trophoblast;trophoblast stem cell;Uterus;Villous

PROJECT_TITLE: Deciphering the role of METTL3 in Mammalian Placenta Development and Maintenance Across Pregnancy

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PMCSR serves as the backbone for diverse research initiatives, highlighted by the utilization of over 200 laboratories engaged in basic, clinical, and translational research. PMCSR's cutting-edge technologies have been pivotal in numerous groundbreaking studies, including interactome mapping elucidating crucial mechanisms in cancer immunity, phosphoproteomics uncovering dysregulation leading to lymphomagenesis, and cell surfaceome profiling aiding immunotherapy target discovery. This award will provide career stability to me and allow me to continue excellence in serving the cancer research community.

PI_NAMEs: SONI, RAJESH KUMAR (contact)

PROJECT_TERMS: anti-cancer research;Automation;Automobile Driving;Award;Basic Science;Cancer Center;cancer genomics;career;Cells;Clinical Research;Collaborations;Communities;Comprehensive Cancer Center;Crystallography;Diagnostic;epigenomics;Fostering;Funding;Grant;Herbert Irving Comprehensive Cancer Center;Immunotherapy;improved;innovation;Laboratories;Lymphomagenesis;Malignant Neoplasms;Maps;mass spectrometer;Medical center;Methodology;novel;Pathogenesis;Peer Review;phosphoproteomics;Population Sciences;precision oncology;programs;Proteomics;Publications;Research;Resource Sharing;Services;Systems Biology;Technology;technology validation;Translational Research;Tumor Biology;Tumor Immunity;tumor microenvironment;tumorigenesis;Universities;Vertebral column

PROJECT_TITLE: Advancing Proteomics Technologies for Cancer Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (M2)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: MEMPHIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: PROJECT NARRATIVE The human pangenome encompasses global genetic diversity missing from the reference genome. This project will develop sequence alignment, population genetics, and data visualization tools that enable new ways to access and understand the pangenome. These innovations aim to catalyze discoveries by making expansive pangenome resources more intuitive for diverse genomics communities.

PI_NAMEs: GARRISON, ERIK  (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Acceleration;Adoption;Algorithms;Alleles;Area;Base Pairing;Base Sequence;Bioinformatics;Biological;Centromere;Communities;Complement;Computer software;Data;data modeling;data resource;data visualization;Dimensions;diverse data;Educational workshop;Elements;empowerment;Equity;Evolution;experience;Foundations;Gene Conversion;Genetic Variation;Genome;genome browser;genome wide association study;genome-wide analysis;Genomics;Genotype;Graph;graph theory;Haplotypes;Health;Heritability;Human;Human Chromosomes;Human Genetics;human pangenome;improved;indexing;innovation;interactive visualization;Intuition;knowledge graph;Link;Maps;member;Methodology;Methods;Modeling;novel;open source;pan-genome;Phenotype;Phylogeny;Population;Population Genetics;public database;reference genome;Research;Research Personnel;Resources;Sequence Alignment;Signal Transduction;Software Tools;Structure;success;symposium;System;Techniques;Technology;Time;tool;two-dimensional;user-friendly;Variant;Visualization;Visualization software;whole genome;Work

PROJECT_TITLE: Building Tools and Community to Make Pangenomes Accessible

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-M (M2)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Depression;Mental Health;Mental Illness;Neurosciences;Pain Research

PHR: NARRATIVE Suffering from both the sensory and affective components of chronic pain continues to be a major burden on quality of life and economies in the US and around the world. Pain and depression are often comorbid, and the lateral habenula is a brain region that has recently been implicated in both. While most studies have focused on the inputs to the lateral habenula, here we propose to investigate which brain region(s) receive output from the lateral habenula to modulate sensory and affective behavioral responses in models of chronic pain and depression.

PI_NAMEs: MARGOLIS, ELYSSA  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: abuse liability;Acute;Address;Affective;allodynia;Amygdaloid structure;Analgesics;Anatomy;Anhedonia;Animals;Anxiety;approach behavior;Architecture;Area;Aversive Stimulus;Behavior;behavior measurement;Behavioral;Behavioral Model;behavioral response;Biological Assay;Brain region;Cell Nucleus;Cells;chronic depression;chronic pain;Clinical;comorbidity;Complement;conditioned place preference;Control Animal;Data;Deep Brain Stimulation;depression model;dopamine system;dorsal raphe nucleus;drug withdrawal;Electrophysiology (science);Elements;Exhibits;experience;Female;Fiber;Fire - disasters;Fright;Glutamates;Habenula;Human;human model;Hypersensitivity;Hypothalamic structure;in vivo;Label;Lateral;Literature;Major Depressive Disorder;male;Measurement;Measures;Mechanics;Mediating;Mental Depression;Methods;Modeling;motivated behavior;Motivation;mu opioid receptors;Mus;negative affect;Negative Reinforcements;nerve injury;neural;neural circuit;Neurons;neurophysiology;neuropsychiatric disorder;neurotransmission;Nociception;Opioid agonist;optogenetics;Output;Pain;pain model;pain processing;pain receptor;pain signal;painful neuropathy;Painless;parabrachial nucleus;Photometry;Physiology;Population;postsynaptic;Preoptic Areas;prescription opioid;presynaptic;Presynaptic Terminals;Property;Quality of life;Rabies;Rattus;Receptor Activation;Receptor Inhibition;Research;response;restraint;restraint stress;Rewards;Rodent;Role;Route;Sensory;Signal Transduction;spared nerve;Specificity;Spinal cord posterior horn;Stimulus;Stress;Symptoms;Synapses;System;Techniques;Testing;Therapeutic Effect;transmission process;Virus;Whole-Cell Recordings

PROJECT_TITLE: Direct lateral habenula projection to a critical pain transmission circuit

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: MOUNTAIN VIEW

ORG_NAME: MAGIC LIFESCIENCE, INC.

PHR: PROJECT NARRATIVE Current syphilis detection methods, especially serological ones, are typically laboratory-based, require a secondary confirmatory assay to reach adequate sensitivity and specificity, and are characterized by challenges that prevent clinicians from obtaining immediate and definitive test results for effective treatment decisions before the patient leaves the clinic. Our multiplexed MagChipTM genital ulcer disease assay and MagChipRTM analyzer will provide one of the first commercially available POC NAAT solutions that will enable untrained users in CLIA-waived settings to discriminate syphilitic ulcers from ulcers caused by other ulcerative diseases. In addition, NAATs currently lack sensitivity outside of primary genital lesions – our robust MagChip chemistry is compatible with multiple sample types, which we will leverage in an innovative clinical study, pooling multiple sample types from the same patient to enhance the sensitivity of our MagChip T. pallidum assay for diagnosing secondary, latent, and congenital syphilis.

PI_NAMEs: NG, ELAINE  (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: accurate diagnosis;Adult;Antibodies;Antimicrobial Resistance;Anus;assay development;Biological Assay;Biosensor;Cervical;Chemistry;Chlamydia trachomatis;Clinic;Clinical;Clinical Research;cohort;Compensation;Complex;Congenital Syphilis;cost;Darkness;design;Detection;detection assay;detection method;Development;Diagnosis;Diagnostic;diagnostic platform;Diagnostic tests;Disease;DNA Probes;effective therapy;Enrollment;Ensure;Exanthema;Genes;Genitalia;Goals;Hemophilus ducreyi;improved;Individual;Infection;innovation;interest;Knowledge;Laboratories;Latent Syphilis;Lesion;Light;Literature;Magic;Magnetism;Medical History;Methods;Microfluidics;Microscopy;Molecular;Molecular Diagnostic Testing;molecular diagnostics;multiplex assay;multiplex detection;Mycoplasma genitalium;Neisseria gonorrhoeae;Noise;novel;Optics;Oropharyngeal;Outcome;pathogen;Patient-Focused Outcomes;Patients;point of care;portability;Pregnant Women;Preparation;prevent;Reflex action;Running;Saliva;Sampling;Sensitivity and Specificity;sensor;Serology;Serology test;Serum;Signal Transduction;Simplexvirus;skills;Specificity;Specimen;standard of care;Swab;Syphilis;Technology;Test Result;Testing;Training;Translating;Treponema pallidum;Trichomonas vaginalis;Ulcer;Vagina;Validation

PROJECT_TITLE: Development of a novel syphilis molecular diagnostic assay for a point-of-care multiplexed genital ulcer panel test on giant magnetoresistive biosensors

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 FDS-M (M1)]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Human Genome;Regenerative Medicine

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE This RC2 consortium will develop a consensus view of intestinal repair and regeneration across diverse injury models in both mouse and human systems, identifying common and unique regenerative programs that are active in different injury contexts. We will functionally interrogate regenerative programs and identify molecular mediators and drugs that can induce a regenerative state. This work will lead to a deep understanding of gut repair and lay the foundation for new fields of research and therapeutics.

PI_NAMEs: BLUTT, SARAH E;BOFFELLI, DARIO ;KLEIN, OPHIR D (contact);SPENCE, JASON ;VERZI, MICHAEL P.

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Atlases;Biological Assay;Biological Models;Cell Proliferation;Cells;Chemicals;Collaborations;college;Communities;Computational Biology;Consensus;Data;data modeling;Data Set;Development;Down-Regulation;Drug Screening;Eligibility Determination;Engraftment;epigenome;epigenomics;experimental study;FDA approved;fetal;Foundations;Future;gain of function;Gene Expression;Generations;Genes;Genetic Transcription;Genomics;Goals;healing;high-throughput drug screening;Homeostasis;Human;human model;Human Pathology;In Vitro;in vitro regeneration;in vivo;in vivo engraftment;Infection;Inflammatory;Injury;injury and repair;intestinal epithelium;intestinal injury;Intestines;irradiation;Joints;Libraries;Link;loss of function;Mediator;Medicine;Methods;Michigan;Modeling;Molecular;Molecular Biology;mouse model;Multiomic Data;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;new therapeutic target;novel;novel therapeutics;Online Systems;Organism;Organoids;Parasitic infection;Pathway interactions;Pharmaceutical Preparations;Physiology;programs;Property;Protocols documentation;Publications;Publishing;Radiation;Reagent;regenerative;Regenerative Medicine;Regenerative response;repaired;Research;Resources;Scientist;Screening Result;Small Intestines;Standardization;stem cell biology;stem cells;Surveys;System;Technology;Testing;Therapeutic;tool;transcriptome;transcriptomics;translational approach;Transplantation;Universities;user-friendly;virology;Virus Diseases;web-accessible;Work

PROJECT_TITLE: Consortium on Intestinal Regeneration and Fetal Reversion: from Atlas to Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-9 (M3)]


NIH_SPENDING_CATS: Aging;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Activity;Prevention;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Regular aerobic exercise is associated with a reduced risk of cardiovascular disease and Alzehimer's disease and its related dementias, due in part to improving vascular health in the peripheral circulation and the brain. Although regular aerobic exercise has been shown to improve vascular health in middle-age/older men it has not consistently improved vascular health in postmenopausal women. The proposed studies will test whether age and sex differences in the underlying biology of vascular aging and molecular transducers with acute and chronic aerobic exercise mediates exercise response variation.

PI_NAMEs: MOREAU, KERRIE  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acute;Adult;Aerobic Exercise;Age;age difference;age effect;age group;Aging;aging related;Alzheimer's Disease;Aorta;Biological;Biological Assay;Biological Process;Biology;Biology of Aging;Blood;Blood Vessels;brachial artery;Brain;brain endothelial cell;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cell Aging;Cell Culture Techniques;Cell Physiology;Cells;Cellular Assay;cerebrovascular;cerebrovascular reactivity;Cerebrum;Chronic;Circulation;Communication;Control Groups;cytokine;Dementia;deregulated nutrient-sensing;detection of nutrient;Development;Disease;Endothelium;Estrogens;Exercise;exercise intervention;exercise training;Exposure to;hallmarks of aging;Health;Heart Rate;Heterogeneity;hormone therapy;Hormones;improved;Inflammation;insight;Intervention;Knowledge;Link;Mediating;men;Messenger RNA;metabolomics;MicroRNAs;microvesicles;middle age;Mitochondria;mitochondrial dysfunction;Molecular;Molecular Profiling;Molecular Target;Nitric Oxide;NOS3 gene;Nucleic Acids;older adult;older men;Older Population;Outcome;Oxidative Stress;particle;Pathway interactions;Peripheral;Persons;Phenotype;post intervention;Postmenopause;preservation;primary outcome;Production;Proteins;Proteomics;proteostasis;Randomized;Reactive Oxygen Species;Recommendation;Research;response;Rest;Serum;sex;Sex Differences;Signal Transduction;Stimulus;Testing;Transcript;transcriptomics;Transducers;treadmill;Variant;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelium;VO2max;Woman

PROJECT_TITLE: Exerkines and the heterogeneity of peripheral and cerebral vascular adaptations to exercise training with aging in women and men

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-A (M1)]


NIH_SPENDING_CATS: Aging;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE This project is a systematic analysis of how the burden of heart failure varies within the United States and how public health and clinical interventions are likely to impact future disease trends in each U.S. state. The project will build on the data and computational infrastructure of the Global Burden of Disease Study to: a) estimate the burden of heart failure for each U.S. county and for each U.S. state forecast that burden to 2060 with stratification by age, sex, ejection factor, race/ethnicity, rurality/urbanicity b) assess the strength of evidence for modifiable risk factors for heart failure and their role in causing current burden, and c) develop new heart failure policy simulations that allow each state to examine the local impact of interventions that can prevent or reduce the burden of heart failure for their population. The results of this project will provide new evidence on the impact of interventions tailored to each U.S. state, allowing policymakers to improve their selection of policies that can reduce geographic health disparities.

PI_NAMEs: ROTH, GREGORY ANDREW (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Age;age stratification;Aging;Air Pollution;Atherosclerosis;burden of illness;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Characteristics;Clinical;Communities;Community based prevention;comparative;Complex;computer infrastructure;Computer Simulation;Computer software;computing resources;Country;County;COVID-19;COVID-19 pandemic effects;Data;data infrastructure;data resource;Data Set;design;disability-adjusted life years;Disease;disease model;Disparity;disparity reduction;Dose;econometrics;Education;EFRAC;Environmental Risk Factor;epidemiological model;Epidemiology;ethnic disparity;Ethnic Origin;Etiology;evidence base;fine particles;Future;General Population;Generations;geographic disparity;Geography;Goals;Health;health care availability;health care delivery;health data;health disparity;Health Policy;Health system;heart dimension/size;Heart failure;hospital readmission;Hospitalization;improved;Income;Inpatients;Intervention;Left Ventricular Ejection Fraction;Life Cycle Stages;Location;Measures;Metabolic;Methods;migration;Modeling;models and simulation;modifiable risk;mortality;Motivation;National Health Policy;Obesity;Outcome;Pathway interactions;Pattern;Persons;Policies;Policy Maker;Population;Population Attributable Risks;population health;Population Projection;Population trends;premature;preservation;Prevalence;prevent;Prevention;Prevention strategy;Public Health;Race;racial disparity;Relative Risks;Research;response;Risk;Risk Assessment;Risk Factors;Role;Rural;rural area;rurality;Septicemia;Series;sex;simulation;Testing;treatment strategy;trend;United States;Update;urban disparity;Urbanicity;Woman;Work;years lived with disability;years of life lost

PROJECT_TITLE: Impact of Interventions on Future Trends in Subnational Burden of Cardiovascular Diseases in the US

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Fentanyl Misuse and Addiction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: BELLINGHAM

ORG_NAME: NORTHWEST INDIAN COLLEGE

PI_NAMEs: ALEXANDER, CHARENE  (contact);JUAREZ, BARBARA A

PROGRAM_OFFICER_NAME: OUDEKERK, BARBARA ANN

PROJECT_TERMS: Acceleration;addiction;Address;Adopted;Alaska;care providers;care systems;Cessation of life;Chairperson;Collaborations;college;Communities;Community Actions;community engagement;community engagement process;Conduct Clinical Trials;Continuity of Patient Care;Data;data dashboard;data management;Data Management Resources;Data Reporting;Data Set;data sharing;Data Sources;Database Management Systems;Databases;Death Rate;Development;disorder prevention;Disparity;Epidemic;evidence base;Evidence based practice;experience;Family;fentanyl overdose;Focus Groups;follow-up;Goals;healing;Health;health disparity;Health Promotion;Health Status;Helping to End Addiction Long-term;high risk;Home;Imagery;implementation intervention;implementation research;implementation science;implementation trial;improved;Indigenous;Individual;Inequity;Information Systems;innovation;Institution;Institutional Review Boards;Intention;interactive tool;intertribal;Intervention;Intervention Studies;Knowledge;Lead;Lummi;Manuals;Maps;Measures;member;Mental Health;Mental health promotion;Metaphor;Modeling;Monitor;novel;novel strategies;operation;Opioid;opioid overdose;opioid use disorder;Outcome;Overdose;overdose death;Pacific Northwest;Pain;participant safety;Personal Satisfaction;Persons;Phase;Policies;Prevention;Process;programs;protective factors;Public Health;public health emergency;public health research;Publications;Recording of previous events;Recovery;recruit;reduced substance use;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Resolution;Resources;response;Risk Reduction;Science;Secure;Services;Site;social health determinants;Source;Spirituality;substance use;Substance Use Disorder;substance use treatment;success;sustained recovery;Swinomish;theories;Theory of Change;Time;Training;Translating;Translational Research;Translations;tribal community;tribal leader;tribal member;Tribes;Universities;Upper Skagit;virtual;Washington;Wellness Program;Work;working group

PROJECT_TITLE: Indigenous Strengths as Solutions in a Public Health Crisis (Project ISH)


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: MONTEZUMA CREEK

ORG_NAME: UTAH NAVAJO HEALTH SYSTEM, INC.

ORG_STATE: UT

PI_NAMEs: HENDY, RICK  (contact);KELLEY, ALAN TAYLOR

PROGRAM_OFFICER_NAME: SMITH, JACLYN D'ANNE

PROJECT_TERMS: Academic support;Acute Pain;addiction;Address;Adoption;Age;Alaska Native;Alaska Native population;alcohol and other drug;alcohol use disorder;Alcohols;American Indians;Area;arm;Attitude;attributable mortality;Awareness;behavioral health;Belief;Budgets;Caring;Cessation of life;Charge;chronic pain;Clinical;clinical care;Clinical Services;cohort;Cohort Studies;Collaborations;Communities;community based participatory research;Community Outreach;community partnership;Comparison arm;Computerized Medical Record;Counseling;County;Crisis Intervention;Data;data infrastructure;data management;Data Reporting;data standards;data warehouse;Death Rate;Dental Care;design;Development;Diagnosis;Diné Nation;Disease;Domestic Violence;Education and Outreach;Emergency response;Ensure;Epidemic;Ethnic Origin;Evaluation;experience;Face;Federally Qualified Health Center;Feedback;flexibility;Focus Groups;Funding;Future;Gender;Goals;Grant;Growth;Health;health care availability;health care delivery;health care disparity;health care quality;health care service;health care service organization;health care settings;Health Personnel;Health Services;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Helping to End Addiction Long-term;Human Resources;human subject;implementation facilitation;implementation process;implementation science;improved;Indigenous;Individual;Influentials;informant;Information Systems;Infrastructure;innovation;Institution;Intervention;Interview;Lead;Leadership;Letters;Location;Medicine;member;Mental disorders;Mental Health;Mission;Modeling;Morbidity - disease rate;mortality;Navajo;Needs Assessment;operation;Operations Research;Opiate Addiction;Opioid;opioid misuse;opioid use disorder;Outcome;Overdose;overdose death;pandemic disease;patient engagement;Patient-Focused Outcomes;Patients;peer support;Performance;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Population;Positioning Attribute;preference;pregnant;Prevalence;Primary Care;Professional counselor;Program Development;Program Evaluation;programs;prospective;Protocols documentation;Provider;Public Health;Race;Recording of previous events;Recovery;recruit;Reporting;Research;Research Activity;research and development;Research Design;Research Infrastructure;Research Methodology;Research Priority;Research Support;Resources;Role;Schools;screening;service intervention;Services;Shapes;Shelter facility;skills;Social Work;Socioeconomic Status;Speed;Standardization;Stimulant;stimulant use disorder;Strategic Planning;Structure;substance use;Substance Use Disorder;success;Surveys;Sweat Lodge;telepsychiatry;Time;Training;treatment services;tribal community;Tribal group;tribal healthcare;tribal institution;tribal member;tribal organization;Tribes;Trust;United States National Institutes of Health;Universities;urban Native American;Utah;Vision;Visit;Wellness Program;Work;Writing

PROJECT_TITLE: Development and Implementation of a Community-Led Research Program in the Utah Navajo Health System


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Most measures of U.S. adult health and longevity lag well behind those of other wealthy countries, particularly for U.S. women, middle-aged adults, racial and ethnic minorities, and areas in the South and Midwest. Explaining this growing U.S. disadvantage necessitates large-scale, coordinated research and data development activities across disciplines. This Network will bring together scientists across disciplines to collectively investigate the U.S. crisis, provide training for Network scientists, and disseminate resources and research to inform decision- makers and improve the health and longevity of the aging population.

PI_NAMEs: AILSHIRE, JENNIFER A (contact);BURGARD, SARAH A.;HARGROVE, TAYLOR ;MONTEZ, JENNIFER KARAS

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Adult;Age;Aging;aging population;Air Pollution;Applications Grants;Area;Asian Americans;Attention;baby boomer;Birth;Black American;Catalogs;caucasian American;climate change;cohort;Collaborations;Country;Data;data resource;data visualization;Databases;Development;directed attention;Disadvantaged;Discipline;Disparity;disparity reduction;Electronic Medical Records and Genomics Network;ethnic minority;Ethnic Origin;evidence base;experience;falls;forging;Fostering;Foundations;Funding;Gender;Geographic Locations;Geography;Grant;Health;health determinants;Health Disparities Research;health disparity;Hispanic;human capital;human data;improved;Income;Individual;Inequality;Infrastructure;innovation;interdisciplinary approach;interdisciplinary collaboration;Interdisciplinary Study;Intervention;Leadership;Life Cycle Stages;Life Expectancy;Link;Longevity;manufacture;Marketing;Measures;meetings;Mentors;middle age;Midwestern United States;Mississippi;mortality;National Institute on Aging;Nature;New York;Occupations;operation;Pattern;Persons;Policies;population health;prospective;Race;racial minority;recruit;Research;Research Personnel;Resources;rural area;Science;Scientist;Sexism;Shapes;Site;social;sociodemographics;Socioeconomic Status;socioeconomics;Structural Racism;Subgroup;Training;training opportunity;trend;United States;webinar;Woman;working group

PROJECT_TITLE: Network on Life Course Health Dynamics and Disparities in 21st Century America Renewal


NIH_SPENDING_CATS: Bioengineering;Burden of Illness;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Health Services;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Schistosomiasis is a neglected tropical parasitic disease with ongoing efforts to achieve elimination as a public health problem through a strategy of mass drug administration. Yet how to efficiently identify focal geographic areas of Schistosoma endemicity and hot spots of high prevalence to inform targeted mass drug administration is limited. The proposed research aims to determine whether more geographically precise mapping with newer rapid urine antigen diagnostics in a sample pooling approach for targeted mass drug administration can improve schistosomiasis control efforts and be cost-effective.

PI_NAMEs: LO, NATHAN  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Accounting;Algorithms;antigen diagnostic;antigen test;Area;Bayesian Method;burden of illness;Calibration;Classification;Clinical Medicine;Collaborations;Communities;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness ratio;Country;Data;Data Set;Diagnostic;disability-adjusted life years;epidemiologic data;Epidemiology;Feces;follow-up;Geographic Locations;Geography;Goals;health data;High Prevalence;Hot Spot;Hybrids;improved;incremental cost-effectiveness;innovation;Interruption;Intervention;Ivory Coast;Lateral;Life Cycle Stages;Location;low and middle-income countries;Low Prevalence;Maps;mathematical model;Measures;Microscopy;Modeling;multidisciplinary;neglect;novel;novel diagnostics;open source;overtreatment;Parasitic Diseases;Persons;Pharmaceutical Preparations;point of care;Policies;Population;Praziquantel;Prevalence;Productivity;programs;Public Health;Recommendation;Refractory;Research;Resources;Risk;Sample Size;Sampling;Schistosoma;Schistosoma mansoni;Schistosomiasis;Sensitivity and Specificity;Site;Snails;Surveillance Methods;surveillance strategy;Surveys;System;Testing;Time;tool;transmission process;Urine

PROJECT_TITLE: Precision mapping of Schistosoma mansoni risk for targeted public health control and elimination

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hematology;Liver Disease

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The proposed research is relevant to public health because elucidation of the molecular basis of neogenin and matriptase-2 in the regulation of hepcidin expression is ultimately expected to increase understanding of the pathogenesis of iron overload disorders and iron-restricted anemia in humans. Thus, the proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that will help understand and treat disorders of iron metabolism including hemochromatosis and anemia.

PI_NAMEs: ENNS, CAROLINE ;ZHANG, AN-SHENG  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Alopecia;Anemia;Animals;BMP2 gene;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;Cell membrane;Complex;Data;design;Development;Disease;Foundations;Gene Proteins;Genes;genetic regulatory protein;Goals;Grant;Hematological Disease;Hemochromatosis;Hepatic;Hepatocyte;hepcidin;Hereditary hemochromatosis;HFE2 gene;Homeostasis;Hormones;Human;In Transferrin;In Vitro;innovation;Integral Membrane Protein;interest;Intervention;Iron;Iron deficiency anemia;Iron Metabolism Disorders;Iron Overload;Iron-Regulatory Proteins;Knowledge;Laboratories;Length;Life;Ligands;Liver;liver ablation;Maintenance;matriptase 2;Mediating;Membrane;Membrane Proteins;Mission;Modeling;Molecular;Molecular Target;mouse model;Mus;Mutant Strains Mice;Mutation;neogenin;Neurons;Normal Range;novel;novel therapeutics;Nutrient;Outcome;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phenotype;Proteins;Proteolysis;Public Health;receptor;Receptor Signaling;Refractory;Regulation;Regulatory Pathway;Research;response;Role;scaffold;secretase;Signal Pathway;Signaling Protein;Testing;transferrin receptor 2;Translating;Transmembrane Domain;trypsin-like serine protease;United States National Institutes of Health;Viral Vector

PROJECT_TITLE: Roles of Neogenin and Matriptase-2 in Iron Homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-D (02)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Regenerative Medicine;Wound Healing and Care

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The proposed research will investigate the biological functions of salivary piRNA in relevance to intraoral wound healing via activation of transposon methylation in oral mucosal epithelial cells. Functionally characterize piRNA with respect to normal physiological functions will provide more definitive insight into the molecular mechanisms of the unique phenotypical properties of oral wound healing and improve oral health therapeutic developments.

PI_NAMEs: LI, FENG  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Alu Elements;Bacteria;Biological;Biological Assay;Biological Process;bisulfite;Body Fluids;Cells;Chronic;Chronic Disease;chronic wound;circular RNA;Cleft Palate;Coupled;Data;Development;embryonic stem cell;Environment;Epigenetic Process;Epithelial Cells;Event;Excision;exosome;Exposure to;Failure;Fistula;Genetic;Goals;Growth Factor;healing;Healthcare;histidine-rich proteins;Human;Hypertrophic Cicatrix;Impairment;improved;In Vitro;in vivo;Infection;Inflammation;Injury;Innate Immune Response;insight;Intake;interest;Intrinsic factor;Keloid;keratinocyte;Knowledge;Mediating;Methylation;MicroRNAs;migration;Modeling;Molecular;mouse model;Mouth Diseases;Mucins;Natural regeneration;new therapeutic target;novel;nutrition;open wound;Operative Surgical Procedures;Oral;Oral health;Oral mucous membrane structure;oral tissue;Outcome;Pain;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Physiological;piRNA;Play;Postoperative Complications;Predisposition;Process;Proliferating;Property;pyrosequencing;re-epithelialization;regeneration function;Regulation;repaired;Reporting;Research;Risk;RNA;Role;Saliva;Salivary;Skin;Skin wound healing;Small RNA;Somatic Cell;Testing;therapeutic development;tissue regeneration;tissue repair;Tissues;Transcript;transcriptome sequencing;Trauma;tumor;Untranslated RNA;Validation;Work;wound;wound closure;wound healing;Wound healing therapy;Wound models

PROJECT_TITLE: The function role of salivary piRNAs in oral wound healing

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 AC (15)]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

PHR: NARRATIVE Most individuals with Fragile X syndrome (FXS) and people with autism experience troublesome hypersensitivity to touch, which leads to avoidance responses, but how this affects social interactions is not known. This project investigates social touch in a mouse model of FXS and in the maternal immune activation mouse model of sporadic autism using an innovative behavioral assay. We hope to identify the circuit changes that lead to avoidance to unwanted social touch, and plan to conduct preclinical studies to test whether certain drugs that act on circuits can ameliorate these deficits in autism mouse models.

PI_NAMEs: PORTERA-CAILLIAU, CARLOS  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Address;Adult;Affect;Amygdaloid structure;Animal Model;Anxiety;Area;Arousal;autism spectrum disorder;avoidance behavior;Behavior;Behavioral Assay;behavioral phenotyping;behavioral response;Biological Assay;Brain;Brain region;Cells;Child;Data;deep learning algorithm;Defect;designer receptors exclusively activated by designer drugs;diagnostic criteria;dimension reduction;distraction;drug action;DSM-V;Electrophysiology (science);experience;Eye;Facial Expression;Fragile X Syndrome;Funding;gaze;Genetic;Grant;Hand;Head;Human;Hypersensitivity;immune activation;in vivo;inattention;Individual;individuals with autism spectrum disorder;innovation;insight;Intervention;Knock-out;Knockout Mice;Knowledge;Laboratories;Learning Disabilities;machine vision;maladaptive behavior;Methods;model of autism spectrum disorder;Modeling;mouse model;Mus;neural;neural circuit;neural correlate;Neurons;novel;Parvalbumins;Pharmacology;Phenotype;Positioning Attribute;preclinical study;Pupil;Quality of life;repetitive behavior;Resolution;response;Reverse engineering;ROC Curve;Running;Saccades;Sensory;sensory stimulus;Severities;Silicon;social;Social Behavior;social deficits;Social Interaction;Somatosensory Cortex;Speed;Stimulus;Symptoms;Tactile;Testing;Touch sensation;Vibrissae;willingness

PROJECT_TITLE: Circuit Defects Underlying Deficits in Social Touch in Fragile X Syndrome

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Disability Research;Neurosciences;Pain Research;Physical Activity;Physical Injury - Accidents and Adverse Effects;Rehabilitation

PHR: PROJECT NARRATIVE Rotator cuff tendinopathy is a common problem. Resistance exercise is a known effective treatment, but not everyone benefits and little is known about the tendon healing response with exercise. In this project, we will track changes in the tendon, outcomes and associated factors to develop a patient-specific exercise approach.

PI_NAMEs: MICHENER, LORI ANN (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Affect;Biological Markers;Brain;brain dysfunction;Brain imaging;care delivery;care outcomes;Caring;central pain;Chronic;chronic pain;Clinical Pathways;Clinical Trials;Collagen;Data;design;Development;Dimensions;disability;Disability outcome;Dose;effective therapy;Electromyography;Exercise;exercise program;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;functional outcomes;Future;Generations;healing;improved;Individual;individualized medicine;Insula of Reil;Knowledge;Magnetic Resonance;Mediating;Muscle;Muscle Cells;Muscle function;novel;Observational Study;Outcome;Pain;pain catastrophizing;pain outcome;pain processing;Pathway interactions;Patient-Focused Outcomes;Patients;psychologic;psychological distress;Psychological Factors;Recovery;Recurrent pain;Reporting;Resistance;resistance exercise;response;Rotator Cuff;Shoulder;Shoulder Pain;somatosensory;Somatosensory Cortex;standard of care;Structure;Tendinopathy;Tendon force;Tendon structure;Thick;Time;treatment response;ultrasound;United States National Institutes of Health;willingness;Work

PROJECT_TITLE: Patient-Specific Factors of Recovery in Rotator Cuff Tendinopathy

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Public Health Relevance Engineered T cells are emerging as promising anti-cancer therapeutic agents, but still show limited efficacy against solid tumors, as they rapidly become ‘exhausted’ due to chronic stimulation by tumor cells. Here we engineer a synthetic signaling feedback circuit that tempers excessive stimulation to boost anti-tumor T cell function. If successful, this synthetic circuit could form the basis for new therapies against solid tumors.

PI_NAMEs: KUEH, HAO YUAN  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Affinity;anti-cancer therapeutic;Antigens;ATAC-seq;Automobile Driving;Biological Assay;Cancer Model;candidate identification;CD8-Positive T-Lymphocytes;Cell Physiology;Cell surface;Cell Therapy;Cells;chimeric antigen receptor;Chronic;cytokine;cytotoxic;Dendritic Cells;design;design,build,test;effector T cell;engineered T cells;Engineering;Environment;Equilibrium;exhaust;exhaustion;experimental study;Feedback;Genes;Genetic;Genomics;Hematologic Neoplasms;Hematopoietic Neoplasms;Image;In Vitro;in vitro Assay;Interphase Cell;Malignant Neoplasms;Measurement;Measures;Melanoma;Modeling;Monitor;Mouse Strains;Mus;neoplastic cell;NFAT Pathway;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;nuclear factors of activated T-cells;Outcome;Output;Pathway interactions;Phenotype;Predisposition;prevent;Process;programs;Proteolysis;prototype;public health relevance;receptor;Receptor Signaling;Reporter;response;Rest;secondary lymphoid organ;Signal Transduction;single-cell RNA sequencing;Solid;Solid Neoplasm;success;synthetic biology;System;T Cell Receptor Signaling Pathway;T cell response;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Therapeutic Agents;Titrations;Transcription Factor AP-1;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Work

PROJECT_TITLE: Engineering synthetic feedback control in T cell signaling for anti-tumor immunity

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_NAME: NORTHWEST PORTLAND AREA INDIAN HLTH BD

PI_NAMEs: TOWN, MATTHEW ALAN (contact)

PROJECT_TERMS: Acute Pain;Address;adolescent substance use;Adopted;Agreement;Area;Behavioral;Caring;Child;chronic pain;Classification;Collaborations;Communication;Communities;community based participatory research;community based research;Community of Practice;Community Relations;community research;Complex;Consultations;Coping Skills;County;culturally appropriate intervention;Data;data access;Data Collection;data ecosystem;data hub;data infrastructure;Data Science;Data Security;data sharing;Decision Making;design;Development;Education;Educational Curriculum;Educational workshop;Effectiveness;effectiveness evaluation;effectiveness research;emotion regulation;Ensure;Environment;Epidemic;Evaluation;Event;experience;Foundations;Funding;Goals;Harm Reduction;healing;Health;health determinants;health equity;Health Promotion;Hearing;Helping to End Addiction Long-term;human subject;Human Subject Research;Iceland;improved;Indigenous;indigenous community;Individual;Information Dissemination;information gathering;Information Systems;Infrastructure;Institution;Institutional Review Boards;Interdisciplinary Study;Interruption;Intervention;Justice;Knowledge;Language;Law Enforcement;Laws;Lead;Leadership;Learning;learning community;Leisures;lens;Measures;Medicine;meetings;member;Methods;Modeling;Municipalities;Native American Research Center for Health;Northwest Tribe;novel;novel strategies;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid use disorder;Outcome;Outcomes Research;Overdose;Pacific Northwest;Pain;Parents;Participant;Peer Group;Personal Satisfaction;Persons;Pilot Projects;Policies;positive emotional state;preference;Prevention;Prevention approach;Prevention program;Prevention strategy;Primary Prevention;Process;Program Development;programs;protective factors;Protocols documentation;psychosocial;Public Health;Recommendation;Recording of previous events;Recovery;recruit;reduced substance use;Reporting;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Subjects;Research Training;Resolution;Resources;response;Risk Factors;Sampling;satisfaction;school environment;Series;Site;skills;social;social determinants;social group;Social Work;Speed;Spirituality;Standardization;Statistical Methods;stimulant use disorder;Strategic Planning;substance use;substance use prevention;success;Surveys;symposium;System;theories;therapy design;Thinking;Time;tool;Training;Training and Infrastructure;Training Support;Translational Research;Travel;tribal community;tribal health;tribal institution;tribal member;tribal Nation;tribal organization;Tribes;Trust;United States National Institutes of Health;Universities;virtual;Washington;Work;Workforce Development;Youth

PROJECT_TITLE: Northwest Regional Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 OTHR-6 (01)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurosciences;Opioids;Pediatric;Racial and Ethnic Minority Health Research;Recovery Support Services;Social Determinants of Health;Substance Misuse

ORG_CITY: LAC DU FLAMBEAU

ORG_NAME: GREAT LAKES INTER-TRIBAL COUNCIL, INC.

ORG_STATE: WI

PI_NAMEs: DENSLINGER, CHRISTINA ;LENZ, KADE  (contact)

PROGRAM_OFFICER_NAME: HAFNER, STEVEN PAUL

PROJECT_TERMS: addiction;Address;Adolescent;aged;Applications Grants;Area;Award;Back;Behavior;Behavioral;Belief;Code;Communities;COVID-19 pandemic;cultural competence;Data;data integration;Data Management Resources;Development;Disease;effective therapy;Effectiveness;Elderly;Eligibility Determination;Evaluation;Event;evidence base;experience;Funding;Goals;healing;Health;health care delivery;health care model;health care service;Helping to End Addiction Long-term;human subject;improved;Indigenous;Individual;innovation;Institutional Review Boards;intertribal;Knowledge;Life;Medical;Medical Care Costs;member;Mental Health;Methodology;Methods;Michigan;Minnesota;Modeling;Modernization;Names;Native Americans;native youth;Office for Human Research Protections;opioid epidemic;opioid mortality;Outcome;Overdose;Ownership;Pathway interactions;person centered;Policies;Policy Maker;preservation;Procedures;Process;programs;Psyche structure;Qualifying;Recovery;recovery services;reduced substance use;Research;Research Personnel;Residential Facilities;resilience;response;Risk Behaviors;Secure;Services;social disparities;social health determinants;Social status;Socialization;Source;Statistical Methods;stem;substance use;Substance Use Disorder;success;System;Trauma;treatment services;tribal community;Tribal Council;tribal leader;tribal Nation;Tribes;United States Dept. of Health and Human Services;United States National Institutes of Health;Wellness Center;Wisconsin;Writing;Youth

PROJECT_TITLE: PERSON-CENTERED RESEARCH ON CULTURE AS HEALTH (PERCH) An Indigenous Model of Wellness


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative  Alzheimer’s disease and related dementias are common, devastating and incurable disorders. The protein alpha-  synuclein  commonly  aggregates  in  these  diseases.  Here,  in  patient  stem- cell  models  and  brain  tissue,  we   thoroughly  investigate  the  mechanisms  through  which  this  protein  aggregates  with  a  view  to  developing  new  understanding and therapies.

PI_NAMEs: KHURANA, VIKRAM  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Affect;Affinity;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Amyloid fibers;amyloid fibril formation;amyloid formation;Autopsy;Biochemical;Biological;Brain;brain cell;brain tissue;Cell Line;Cell model;cell type;Cells;Ceramides;cerebral atrophy;Characteristics;Circular Dichroism Spectroscopy;Coculture Techniques;conformer;Data;Dementia with Lewy Bodies;Development;Diffuse;Disease;Disparate;dopaminergic neuron;Electron Microscopy;Equation;experimental study;Fluorescence;Future;genetic manipulation;Genetic study;glucosylceramidase;Glucosylceramides;Goals;Grant;Heterozygote;Homeostasis;Human;Human Genetics;human induced pluripotent stem cells;human stem cells;Image;Immunofluorescence Microscopy;Impaired cognition;In Vitro;in vitro Assay;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;interest;Intervention;kindred;Knock-in;Knock-out;Lead;Lesion;Lewy Bodies;Lewy body pathology;Lipids;Membrane;Membrane Lipids;Membrane Proteins;mimetics;misfolded protein;Modeling;Morphology;mouse model;Multiple System Atrophy;Mutation;Nerve Degeneration;Neuroglia;Neurons;Nuclear Magnetic Resonance;Oligodendroglia;Parkinson's Dementia;Pathogenicity;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;Periodicity;pharmacologic;Phosphorylation;Physiological;pre-formed fibril;protein aggregation;Proteins;Proteolysis;Reporter;Saturated Fatty Acids;serial imaging;Series;Side;Spanish;Sphingolipids;Stearoyl-CoA Desaturase;stem cell model;Synaptic Vesicles;synucleinopathy;System;tau Proteins;tau-1;Testing;Toxic effect;trafficking;Transgenic Mice;Transgenic Organisms;validation studies;Vesicle;Work

PROJECT_TITLE: Elucidating the Biological Differences Between Distinct Fibrillar and Non-Fibrillar Alpha-Synuclein Inclusions in Human Stem-Cell Models

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ORG_CITY: DAVIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The proposed research is relevant to the part of NIH’s mission that pertains to improving human health by identifying the mechanisms responsible for fungal infections of the central nervous system so that novel therapeutics can be developed to prevent brain infections.

PI_NAMEs: GELLI, ANGIE  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;aerosolized;Area;Aspergillus;Autopsy;Binding;Blood;blood-brain barrier crossing;blood-brain barrier penetration;blood-brain barrier permeabilization;Brain;brain endothelial cell;Brain Injuries;Candida albicans;Cause of Death;CD44 gene;cell motility;Cells;Central Nervous System;Central Nervous System Agents;Central Nervous System Fungal Infections;Central Nervous System Infections;Cerebral endothelium;Cessation of life;Chronic;Coccidioides;Columbidae;Complex;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;Cystic Lesion;Cytoskeleton;Data;design;Development;Disease;Drops;Elements;Endocytosis;Environment;EphA2 Receptor;experimental study;Fungal Spores;fungus;Goals;Health;Histoplasma capsulatum;Hospitalization;Human;improved;In Vitro;in vivo;Infection;Inhalation;innovation;Invaded;Knock-out;Knowledge;Label;Mediating;Meningoencephalitis;migration;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Movement;Mucor;Nature;neurotropic;novel strategies;novel therapeutics;pathogen;Pathogenesis;pathogenic fungus;Pathologic;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;prevent;Process;Proliferating;prophylactic;Publishing;Receptor Protein-Tyrosine Kinases;recruit;Reporting;Reproduction spores;Research;response;Risk;Role;Route;Series;Signal Transduction;Soil;spatiotemporal;spheroids;Structure of parenchyma of lung;Technology;Testing;Time;trafficking;Transactivation;Trees;United States National Institutes of Health;Work

PROJECT_TITLE: The molecular basis for the translocation of fungi from blood-to-brain.

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Following epilepsy surgery, roughly half of patients will continue to have seizures, and 70-90% will remain on anti-seizure medications. Using data recorded from the brains of epilepsy patients, we propose to develop and validate computerized tools to accurately and objectively identify epileptic brain regions. This will improve surgical decision making, make epilepsy surgery available to more patients, and ultimately improve the lives of patients with the most severe types of epilepsy.

PI_NAMEs: LOPOUR, BETH ANN (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Accounting;anti-epileptic agents;Anticonvulsants;Area;Biological Markers;Blinded;Brain;brain electrical activity;Brain imaging;Brain region;brain tissue;Characteristics;childhood epilepsy;Classification;Clinical;clinical implementation;Clinical Trials;Complex;computerized tools;Coupled;Data;Decision Making;density;Detection;Electrocorticogram;Electrodes;Electroencephalography;Electrophysiology (science);Epilepsy;Event;Excision;Failure;Freedom;Frequencies;Goals;High Frequency Oscillation;high standard;Implant;Implanted Electrodes;improved;improved outcome;Individual;Intuition;Knowledge;Measurement;Measures;Methodology;Methods;minimally invasive;Modeling;Monitor;Morphology;neurotransmission;novel;Operative Surgical Procedures;Outcome;Pathologic;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physiological;Postoperative Period;Procedures;prospective;Prospective Studies;Quality of life;Recommendation;Research;Resected;risk minimization;Seizures;Sensitivity and Specificity;Signal Transduction;simulation;Specificity;Surface;Surgeon;Surgical Management;Techniques;Testing;Tissues;Vision;Work

PROJECT_TITLE: Seizure localization for epilepsy surgery using high frequency electrophysiological markers

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative This study characterizes the tissue response and safety limits of electrical micro-stimulation in multiple non- neuronal brain cells over time. Electrical stimulation is being used to probe brain activity and also treat a wide- range of diseases (e.g. Parkinson’s disease). A state-of-the-art imaging approach is proposed to guide the use of stimulation to induce changes in brain activity, including progenitor proliferation and differentiation.

PI_NAMEs: KOZAI, TAKASHI DANIEL YOSHIDA (contact)

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: 2',3'-Cyclic-Nucleotide Phosphodiesterases;angiogenesis;Astrocytes;Automobile Driving;Basic Science;Behavior;Biology;Biophysics;Blood flow;Blood Vessels;Brain;brain cell;brain tissue;Calcium;Cell Lineage;Cells;Charge;Chemicals;Chronic;Clinical;clinical application;clinical implementation;Coupled;Databases;Degenerative Disorder;design;Development;Device Designs;Disease;DsRed;electric impedance;Electric Stimulation;electrical microstimulation;Electrodes;Electrophysiology (science);Event;excitotoxicity;Foreign Bodies;Frequencies;Future;Health;Health Status;Image;imaging approach;imaging platform;Imaging Techniques;Imaging technology;Immune;Immunohistochemistry;implantable device;implantation;improved;in vivo;in vivo imaging;Injury;Intervention;Investigation;Mental Depression;Microelectrodes;Microglia;microstimulation;Molecular;Monitor;Morphology;multiphoton imaging;Mus;myelination;Myelogenous;Nerve Regeneration;neural network;Neuroglia;neuronal excitability;Neurons;neuroregulation;Neurosciences;Neurosciences Research;neurovascular coupling;oligodendrocyte progenitor;Oligodendroglia;Optics;Parkinson Disease;Patients;Pericytes;Periodicity;Personal Satisfaction;Phase;Photic Stimulation;Physiological;predictive modeling;Prevalence;Proliferating;Property;Protein Analysis;ratiometric;Recommendation;Regenerative Medicine;Research;response;RNA analysis;Safety;sensor;Sensory;Signal Transduction;Smooth Muscle Myocytes;spatiotemporal;Spectrum Analysis;stem cell differentiation;stem cell proliferation;stem cells;Stimulus;Supporting Cell;Techniques;Therapeutic;Time;tissue repair;Tissues;Transgenic Animals;Vascular Smooth Muscle;vasoconstriction;Vasodilation;Visual Cortex;voltage;Work

PROJECT_TITLE: Elucidating electrical stimulation induced non-neuronal activity using emerging in vivo imaging technology and electrophysiology


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Mental Health;Neurosciences;Nutrition;Obesity;Social Determinants of Health

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PI_NAMEs: PEREIRA CARDOSO AZEVEDO, ESTEFANIA  (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Acceleration;Adult;Affect;Automobile Driving;Behavioral Assay;Binge Eating;Bioinformatics;Biometry;Brain;brain circuitry;brain dysfunction;career development;cell type;Centers of Research Excellence;comorbidity;Consumption;Data;Disease;early life stress;Eating Behavior;Emotions;Exposure to;feeding;Feeding behaviors;Funding;Future;Genes;Genetic;Impairment;in vivo calcium imaging;in vivo imaging;Intake;Lateral;Link;Mentorship;Molecular;Molecular Profiling;Monitor;motivated behavior;Mus;nervous system development;neurodevelopment;Neurodevelopmental Disorder;Neurons;Neurotensin;next generation sequencing;Obesity;Pathway interactions;programs;Research Personnel;Rewards;Rodent;Role;Self-control as a personality trait;Social Interaction;Stimulus;Testing;Transcript;United States National Institutes of Health

PROJECT_TITLE: The Role of Early Life Stress in Feeding Behaviors


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Nutrition;Prevention

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE Age-related declines in vascular function contribute to increased risk of cardiovascular diseases. This project will provide new insight into the mechanisms (reasons) by which a mitochondria-targeted antioxidant (MitoQ) may improve vascular endothelial function in older adults by determining the effects of changes in factors circulating in blood on endothelial cell function. Overall, this project will elucidate the beneficial effects of MitoQ supplementation on vascular function, which has implications for reducing the risk of cardiovascular disease with advancing age.

PI_NAMEs: MURRAY, KEVIN OWEN (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Adult;Age;age related;age related decline;Age Years;Aging;Antioxidants;Aorta;Back;Biological Availability;Biomedical Research;Blood;Blood Vessels;brachial artery;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Cell Physiology;Chronic;Circulation;Clinical Trials;Crossover Design;Data;Development;Double-Blind Method;Elderly;Endothelial Cells;endothelial dysfunction;Endothelium;experience;Exposure to;extracellular vesicles;Extramural Activities;Funding;Future;Human;improved;in vivo;insight;International;Intervention;Laboratories;Learning;Low Density Lipoprotein Receptor;LOX gene;Mediating;Mediator;men;Mentors;MicroRNAs;middle age;Mitochondria;Molecular;Molecular and Cellular Biology;Morphology;Nitric Oxide;novel;novel strategies;older adult;oxidized low density lipoprotein;Phase;Physiology;pilot trial;Placebos;Plasma;Positioning Attribute;Postdoctoral Fellow;Production;Randomized;Reactive Oxygen Species;receptor-mediated signaling;Recording of previous events;Research;Research Personnel;Research Project Grants;Research Training;Risk Reduction;Role;Sampling;Scientist;seal;skills;Small Interfering RNA;Source;Supplementation;Training;United States National Institutes of Health;Vascular Diseases;vascular endothelial dysfunction;Vascular Endothelium;Woman

PROJECT_TITLE: Mitochondria-targeted antioxidant supplementation for improving age-related vascular dysfunction in older adults: the role of circulating factors