NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Rehabilitation

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative. Every year, more than 500,000 patients undergo cardiothoracic operations for heart and lung disease. After surgery, patients suffer from pain, fatigue, and disturbed sleep for weeks to months and up to 32% of patients develop postoperative complications which lead to unplanned readmissions and a 6-fold increase in mortality risk. The overarching goal of this research is to use machine learning analysis of high- resolution physiologic data—collected by wearable technology—to detect postoperative complications at their earliest, subclinical stage, prior to symptom onset and predict the quality of a patient’s postoperative recovery. The use of such algorithms for cardiothoracic surgery patients will have significant public health impact, potentially enabling earlier detection of postoperative complications, greater reduction in the severity of complications, earlier outpatient intervention that can improve recovery, and/or greater decreases in unplanned hospital readmissions.

PI_NAMEs: LI, XIAO ;YANG, CHI-FU  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: algorithm development;Algorithms;Biometry;Cardiac Surgery procedures;Cardiovascular system;Caring;Classification;Complication;cost;COVID-19;COVID-19 detection;COVID-19 early detection;critical period;Data;Detection;Development;Early Diagnosis;experience;Family member;Fatigue;Frequencies;Future;Goals;Health;Health Care Costs;Health Personnel;Health Status;Heart Diseases;high risk;Home;hospital readmission;Hospitals;improved;improved outcome;innovation;Intervention;Learning;Link;Lung;Lung Diseases;Lyme Disease;Machine Learning;machine learning algorithm;Methods;Monitor;mortality;mortality risk;novel;operation;Operative Surgical Procedures;Outcome;Outcome Measure;Outpatients;Pain;Patient Discharge;Patient Monitoring;Patient Outcomes Assessments;Patients;Pattern;personalized care;personalized predictions;Physiological;Pilot Projects;Postoperative Care;Postoperative Complications;Postoperative Period;postoperative recovery;preemptive intervention;Public Health;Quality of life;randomized trial;real time monitoring;Recovery;Research;Resolution;Severities;Signal Transduction;Sleep disturbances;Symptoms;System;Telemedicine;Testing;Thoracic Surgical Procedures;Time;Validation;Viral;Visit;wearable data;wearable device

PROJECT_TITLE: Using Wearable Technology to Assess Recovery and Detect Post-Operative Complications Following Cardiothoracic Surgery

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Nutrition;Obesity;Patient Safety;Physical Activity;Prevention;Primary Health Care;Telehealth

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Many people struggle not only to lose weight through changes in diet and physical activity, but also to maintain weight loss once they have achieved it. In a previous study, our team designed and deployed a weight maintenance intervention that was delivered through the patient portal of an electronic health record (EHR) and found that patients who tracked their weight, diet, and physical activity and also received coaching had better success with maintaining recent intentional weight loss than patients who tracked but did not receive coaching. We propose to repeat the intervention in a new health care system and train routine health care staff (e.g., medical assistants and nurses) to be coaches, a more sustainable model that will allow ongoing intervention delivery after the proposed study ends.

PI_NAMEs: CONROY, MARGARET B (contact);KAWAMOTO, KENSAKU

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Behavior Therapy;Body Weight;Body Weight Changes;Body Weight decreased;Chronic;Chronic Care;Clinic;Clinical;Clinical assessments;cost;Cost Measures;dashboard;design;Development;diabetes risk;Diet;Effectiveness of Interventions;Electronic Health Record;evidence base;experience;follow-up;Fostering;Future;Health;health care settings;health information technology;Healthcare;Healthcare Systems;implementation design;Individual;Information Systems;innovation;Insurance Carriers;Intervention;intervention delivery;intervention mapping;Life Style;Maintenance;Managed Care;Maps;Medical;Medical Care Team;Medicare/Medicaid;Modeling;Nurses;nutrition;Obesity;obesity treatment;Participant;patient population;patient portal;Patients;Persons;Phase;Physical activity;post implementation;Pragmatic clinical trial;Primary Care;primary care practice;primary care team;primary outcome;programs;Protocols documentation;Provider;Publishing;Randomized;randomized, clinical trials;relapse prevention;Research Project Grants;Research Support;Resources;Services;Site;success;System;team-based care;Technology;Testing;tool;Training;United States;Universities;Update;Utah;Weight;weight maintenance;Weight maintenance regimen;Work

PROJECT_TITLE: Promoting Real World Implementation of an Evidence-Based Weight Management Intervention in Primary Care


ADMINISTERING_IC: GM

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  The organelle trans-Golgi network (TGN) serves as the major sorting compartment and the center for modifications of newly synthesized proteins. In this proposal we aim to dissect the conserved molecular and cellular mechanisms governing TGN remodeling by microbial factors and study the effects on eukaryotic cellular processes. Our discoveries will advance our understanding of TGN morphology maintenance and functions, which will lay the foundation for rational design of therapeutics for a wide variety of human diseases.

PI_NAMEs: CHEN, JUEQI  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TITLE: Trans-Golgi Network Remodeling by Microbial Factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: RELEVANCE In response to cancer invasion of the liver, hepatic stellate cells (HSCs) are activated into myofibroblasts by tumor-derived factors, such as TGFβ, and the activated-HSC/myofibroblasts in turn promote liver metastasis. This proposal will study how TGFβ promotes plasma membrane glucose transporter 1 and glucose transport into HSCs that fuels activation of HSCs into metastasis-promoting myofibroblasts. The results will advance our understanding of HSC biology and help identify new targets to inhibit HSC activation and the prometastatic liver microenvironment.

PI_NAMEs: KANG, NINGLING  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: aerobic glycolysis;Binding;cancer cell;cancer imaging;Cell membrane;Cells;Cellular biology;Cellular Metabolic Process;Cholesterol;Colorectal;Cre-LoxP;Data;Endosomes;Fibroblasts;Genetic Recombination;Glucose;glucose transport;Glucose Transporter;glucose uptake;Goals;Growth;Hepatic;Hepatic Stellate Cell;Hepatocyte;implantation;In Vitro;in vivo;Injections;Intervention;Invaded;knock-down;Knock-out;Knockout Mice;Lipids;Liver;liver development;Liver diseases;Liver neoplasms;Malignant Neoplasms;Mediating;Metabolic;Metastatic Neoplasm to the Liver;Methods;mouse model;Mus;Myofibroblast;Neoplasm Metastasis;neoplastic cell;novel;Phosphorylation;Plasma;Portal vein structure;prevent;programs;Protein Isoforms;Protein Tyrosine Kinase;Proteins;rab GTP-Binding Proteins;Regulation;response;Signal Pathway;Signal Transduction;SLC2A1 gene;Sphingolipids;Testing;TGFB1 gene;trafficking;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;tumor;tumor microenvironment;Tumor Promotion;Tumor-Derived;vasodilator-stimulated phosphoprotein;Work

PROJECT_TITLE: Hepatic Stellate Cell Regulation of Metastatic Growth in the Liver

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Breast Cancer;Cancer;Clinical Research;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The proposal aims to study implant-associated immune reactions mediated via bacterial biofilms. Lipid metabolites formed due to host-biofilm interaction can act as immune-modulators. Guided by patient-derived data, this grant application investigates the mechanism of CD4+ T cell activation by biofilm derived 10-HOME.

PI_NAMEs: SINHA, MITHUN  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Adherence;Adipose tissue;aging population;American;Animal Model;Applications Grants;Autoimmune;Bacteria;Biological;Biological Specimen Banks;Black Box;Breast;capsule;career;CD4 Positive T Lymphocytes;Chronic;Collagen;Connective Tissue Diseases;Cosmetics;Data;Dioxygen;Elective Surgical Procedures;experience;eye dryness;Failure;Fatigue;Fatty Acids;Foundations;Future;gender affirmation;Growth;Hip region structure;hip replacement arthroplasty;Home;host microbiota;Immune;Immune response;Immunologist;Immunomodulators;immunoreaction;Implant;implant material;implantable device;improved mobility;In Vitro;in vivo;Infection;Inflammation;Inflammatory Response;Internal Breast Prosthesis;Knee;knee replacement arthroplasty;Laboratories;Life Expectancy;Link;Lipids;Malignant Breast Neoplasm;Mammaplasty;Mammary Gland Parenchyma;Mastectomy;Mediating;Medical Device;medical implant;member;Metals;microbial;Microbial Biofilms;Modeling;Molecular;Mus;Myalgia;Names;National Institute of Allergy and Infectious Disease;Octadecenoic Acids;Oleic Acids;Operative Surgical Procedures;Oral cavity;Orthopedics;oxidation;oxidized lipid;Pathogenesis;pathogenic bacteria;Pathway interactions;Patients;peripheral blood;Persons;Plastic Surgeon;Polymers;Prevalence;Prognosis;programs;prophylactic mastectomy;Publications;Quality of life;Reaction;reconstruction;Replacement Arthroplasty;Reporter;Reporting;Research;Research Personnel;response;Role;Sampling;Second Look Surgery;Silicones;Sterility;Surface;Surgeon;Symptoms;Syndrome;T-Cell Activation;Testing;Texture;Th1 Cells;Tissues;transcription factor;United States;United States Food and Drug Administration;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Implant Biofilm Mediated Immune Response


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Narrative The proposed research is relevant to public health because defining the contribution of senescent cells to neu- rodegenerative disease using mouse models is ultimately expected to fundamentally increase our understand- ing of the pathogenesis of disease in humans, as well as elucidate how aging contributes to these alterations. Through these efforts, transformative clinical interventions for treating patients plagued by neurodegenerative pathologies like Alzheimer’s disease can be developed. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge that will help to reduce the burdens of hu- man disability.

PI_NAMEs: BAKER, DARREN  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Age;age related;age related neurodegeneration;Age related pathologies;Age-associated memory impairment;age-related disease;Aging;aging population;aging related;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease patient;Astrocytes;Attention;Attenuated;attenuation;Autopsy;Biology of Aging;Brain;CDKN2A gene;Cell Cycle;Cell Cycle Arrest;cell type;Cells;Cellular biology;Characteristics;chemokine;Clinical;Cognition;Cognitive aging;Comprehension;cytokine;Data;defined contribution;Deposition;Deterioration;Development;disability;Disease;disease model;Disease Progression;Elderly;Excision;Exhibits;Functional disorder;genetic approach;Geroscience;Goals;Growth Factor;Human;Impaired cognition;improved;Inflammatory;innovation;interdisciplinary approach;Intervention;Knowledge;Laboratories;Laboratory mice;Life;life span;Matrix Metalloproteinases;Methods;Microglia;Mission;Molecular;mouse model;Mus;Nerve Degeneration;neural;Neurobiology;Neurodegenerative Disorders;Neurofibrillary Tangles;normal aging;novel;novel strategies;Outcome;Pathogenesis;Pathology;Patients;pharmacologic;prevent;Prevention;preventive intervention;Probability;Process;Public Health;rate of aging;Research;Role;senescence;senescence associated secretory phenotype;senescent cell;Senile Plaques;senolytics;senomorphic;Severities;Severity of illness;Short-Term Memory;Site;Tauopathies;Testing;Therapeutic;Therapeutic Intervention;therapy development;Tissues;Transgenic Mice;United States National Institutes of Health;Work

PROJECT_TITLE: Effects of senescence to AlzheimerÃ¢ÂÂs disease pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(50)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE  This application proposes to renew and expand the NINDS Human Biospecimen and Data Repository in Neurological Disorders called the BioSpecimen Exchange for Neurological Disorders (BioSEND). Based on our success in establishing a widely used biospecimen repository, we plan further improvements and expansion of BioSEND to meet the NINDS mission to increase biobanking to support basic, translational and clinical research in neurological disorders. We propose to pursue the following specific aims for the next five years.

PI_NAMEs: FOROUD, TATIANA M. (contact)

PROGRAM_OFFICER_NAME: PRICE, REBECCA CHRISTINE

PROJECT_TERMS: Aliquot;Award;Basic Science;biobank;Biological Markers;Biological Specimen Banks;Blinded;Catalogs;Cerebrospinal Fluid;Chronic Fatigue Syndrome;Clinical Data;Clinical Research;Communities;Custom;Data;Data Coordinating Center;data management;data repository;data sharing;Dementia with Lewy Bodies;Disease;DNA;Ensure;Epilepsy;experience;Faculty;Frontotemporal Dementia;Funding;Genetic;Growth;Human;Huntington Disease;improved;Indiana;Infrastructure;innovation;Institution;Laboratories;Leadership;Lewy Body Dementia;Link;material transfer agreement;Medical Research;Mission;Names;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Parkinson Disease;Peripheral Blood Mononuclear Cell;Plasma;Protocols documentation;quality assurance;Quality Control;repository;Research;Research Personnel;Research Subjects;Resources;response;RNA;Saliva;Sampling;Sampling Studies;Science;Secure;Serum;Site;Spinocerebellar Ataxias;success;Time;Training;Translational Research;Traumatic Brain Injury;Universities;Urine;vascular cognitive impairment and dementia;web site;Work

PROJECT_TITLE: Biospecimen Exchange for Neurological Disorders (BioSEND)


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Sleep Research

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: Challenging behaviors are common in youth with autism spectrum disorder (ASD) and appear to escalate at the time of puberty and adolescence. Developmental changes in sleep and the circadian regulation of sleep may contribute to the escalation of challenging behavior in ASD youth during this time. The present study will evaluate cross-sectional and prospective associations between circadian rhythms, sleep, and challenging behavior in puberty-aged youth with ASD, focusing on those most severely affected (e.g., those who have minimal verbal ability and/or comorbid intellectual disability) as they tend to be most at-risk and understudied.

PI_NAMEs: TAYLOR, BRIANA J (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Adolescence;Adolescent;adolescent with autism spectrum disorder;advanced analytics;Affect;Age;age group;aged;Aggressive behavior;alertness;analytical method;autism spectrum disorder;Behavior;Behavioral;circadian;Circadian desynchrony;circadian regulation;Circadian Rhythms;Clinical;Code;Cognition;Communities;comorbidity;comparison group;daily functioning;Dangerous Behavior;Data Analyses;Development;Drowsiness;Ecological momentary assessment;Education;Enrollment;Exclusion;Exhibits;Family Caregiver;FDA approved;Foundations;Future;Goals;Home;Hospitalization;Hospitals;human old age (65+);improved;improvement on sleep;Individual;Individual Differences;inpatient psychiatric treatment;Intellectual functioning disability;Intervention;Intervention Studies;Light;Link;Longitudinal Studies;Measures;Mediating;Melatonin;Mentors;Methodology;Methods;minimally verbal;Modeling;modifiable risk;Moods;novel;Phase;Phototherapy;Polypharmacy;Polysomnography;Population;Populations at Risk;Positioning Attribute;Process;Production;prospective;Prospective Studies;Psychiatric Hospitals;psychiatric inpatient;pubertal timing;Puberty;Research;Research Personnel;Resistance;Resources;Risk;Risk Factors;Role;Salivary;Sampling;Schools;Science;Self-Injurious Behavior;Sensory;Sleep;Sleep Disorders;sleep regulation;Sleep Wake Cycle;System;Systematic Bias;Techniques;Testing;Therapeutic;therapy development;Time;Training;wearable sensor technology;Work;Youth

PROJECT_TITLE: Circadian phase, sleep, and challenging behavior in autism spectrum disorder


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW HAVEN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE This project seeks to identify the fundamental physiological role of microRNA-33 and Liver X Receptor in endothelial cell metabolism. Additionally, it will identify how changes in these pathways impact endothelial cell function and dysfunction in atherosclerosis. The proposed research is relevant to public health and to the NIH’s mission because it will broaden our mechanistic understanding of the molecular regulation of endothelial metabolism in cardiovascular diseases.

PI_NAMEs: CITRIN, KATHRYN  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;Affect;Anti-Inflammatory Agents;Antiatherogenic;atherogenesis;atheroprotective;Atherosclerosis;ATP binding cassette transporter 1;Attenuated;Behavior;Binding;Biogenesis;Cardiovascular Diseases;Cell Physiology;cell type;Cells;Cellular Metabolic Process;Cholesterol;cytokine;Data;Elements;Endothelial Cells;Endothelium;Enzymes;Excision;experimental study;fatty acid oxidation;Functional disorder;Gene Expression;gene network;Gene Proteins;Generations;Genes;Genetic;Genetic Transcription;genomic data;Goals;Hepatic;High Density Lipoproteins;Homeostasis;Hypoxia;in vitro testing;Inflammation;Inflammatory;Inflammatory Response;insight;Label;Ligands;Link;lipid metabolism;Lipids;Literature;Liver X Receptor;loss of function;Macrophage;Maintenance;Maps;Mesenchymal;Messenger RNA;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;MicroRNAs;Mission;Molecular;mouse model;Mus;neglect;Nitric Oxide;novel;Nuclear Receptors;oxidation;Oxidation-Reduction;Pathway interactions;Permeability;Phenotype;Physiological;Post-Transcriptional Regulation;posttranscriptional;prevent;Process;programs;Proteomics;Public Health;receptor;Receptor Signaling;Regulation;Repression;Research;response;Role;Scheme;shear stress;Signal Transduction;Sterols;Stimulus;Testing;therapeutic target;transcription factor;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Untranslated RNA;Vascular Diseases;vascular inflammation

PROJECT_TITLE: Novel Transcriptional & Post-Transcriptional Regulators of Endothelial Metabolism in Atherosclerosis


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BLACKSBURG

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE: A comprehensive atomic-level annotation of protein structures is essential for understanding the molecular basis of complex diseases and facilitating structure-based drug design. Lack of structural annotation of a major fraction protein universe, the so-called dark families, is a key gap in our understanding of molecular biology and diseases. This research bridges the gap by developing and applying data-driven computational modeling and refinement methods on genomic scale to predict high-quality structures covering the dark proteome, thus accelerating drug discovery leading to improved human health.

PI_NAMEs: BHATTACHARYA, DEBSWAPNA  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Algorithms;Amino Acid Sequence;Automobile Driving;Basic Science;Bioinformatics;biological systems;Biology;Collaborations;Communities;Complex;Computational Biology;Computer Models;Computer software;Darkness;Data;Databases;deep learning;Development;Disease;Drug Design;drug discovery;Family;Fostering;genome-wide;Genomics;Health;Homology Modeling;Human;improved;Infrastructure;Laboratories;Medicine;member;Methods;Modeling;Molecular;Molecular Biology;Molecular Conformation;Molecular Disease;National Institute of General Medical Sciences;next generation;novel;Play;programs;Protein Family;protein folding;protein structure;protein structure prediction;Proteins;Proteome;public database;Research;Research Personnel;Resolution;restraint;Structure;Supercomputing;Techniques;training opportunity;Underrepresented Populations;web server

PROJECT_TITLE: Data-driven Computational Modeling and Refinement of Protein Structures on Genomic Scales

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: TEMPE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Almost half a million people have died from opioid overdoses in the last 20 years, despite the existence of treatments that are known to improve outcomes for the 2 million people with opioid use disorder. Our study will investigate the differences in use of treatments and the quality of care by race, ethnicity, age, and gender, to improve access to high-quality care.

PI_NAMEs: DOMINO, MARISA ELENA (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Accounting;Adult;Affect;Age;age difference;age group;Automobile Driving;behavioral health;beneficiary;Black Populations;Black race;Caring;Chronic;Clinical;Communities;comorbidity;contextual factors;Country;County;COVID-19;COVID-19 pandemic;Data;Death Rate;design;Diagnosis;Dimensions;disadvantaged background;Disparity;Electronic Health Record;Environment;Epidemic;Equity;ethnic difference;ethnic disparity;Ethnic Origin;Fee-for-Service Plans;Gender;geographic difference;Geographic Locations;Geography;health care disparity;health care quality;health equity;Health Personnel;Healthcare Systems;Improve Access;improved;improved outcome;Incentives;Individual;innovation;Insurance;Interruption;intersectionality;Latinx;Managed Care;Medicaid;Medical;Medicare claim;medication for opioid use disorder;men;Monitor;Neighborhoods;North Carolina;older adult;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;Overdose reduction;pandemic disease;Pathway interactions;Pattern;Patterns of Care;Persons;Policies;Policy Maker;Prevalence;Primary Care;Privatization;programs;Provider;Qualifying;Quality of Care;Race;racial difference;racial disparity;racial diversity;Racial Segregation;Research;residential segregation;rurality;social health determinants;Socioeconomic Status;Source;Structural Racism;Surface;Testing;Time;treatment pattern;treatment services

PROJECT_TITLE: Unpacking Disparities in Opioid Use Disorder Treatment Quality

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Rural Health;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: MILWAUKEE

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Our objective is to develop and pilot 3T-Prevent (i.e., telementoring, treatment, testing, and prevention) using a hybrid type-1 effectiveness-implementation design via a stepped-wedge randomized controlled trial in three HIV/STI testing clinics in Oklahoma. Intervention activities include detailing clinics and providers to support distribution of HIV and syphilis self-testing kits with patient-delivered partner therapy (PDPT) to sexual minority men; training and telementoring providers to deliver theoretically guided counseling sessions to support self- testing, PDPT, and HIV pre-exposure prophylaxis (PrEP) use among patients and partners; and optimizing PrEP prescribing/referrals and linkage to HIV care. The Consolidated Framework for Implementation Research (CFIR) will be used to better understand barriers and facilitators of the proposed implementation strategy, and RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) will be used to guide development and preliminary effectiveness evaluation of 3T-Prevent.

PI_NAMEs: HUBACH, RANDOLPH D;JOHN, STEVEN A (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Adoption;Advocate;AIDS prevention;bacterial community;Bisexual;Caring;Chlamydia;Clinic;Collaborations;combination intervention strategy;Communication difficulty;Communities;community advisory board;Computerized Medical Record;Consolidated Framework for Implementation Research;Counseling;design;Development;Diagnosis;Diagnostic Reagent Kits;Effectiveness;effectiveness evaluation;effectiveness/implementation design;Epidemic;ethnic minority;Evaluation;experience;Feedback;Focus Groups;Future;Gays;Goals;Gonorrhea;Health Personnel;Heterosexuals;HIV;HIV/STD;Human immunodeficiency virus test;Hybrids;implementation evaluation;implementation strategy;Incidence;Inequity;Infection;informant;Intervention;Interview;men;men who have sex with men;Methods;Nurses;Oklahoma;Patients;Pharmaceutical Preparations;Phase;Population;pre-exposure prophylaxis;Prevalence;prevent;Prevention;Prevention approach;prototype;Provider;racial minority;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;risk perception;Rural;self testing;Services;sex;sexual minority men;Sexually Transmitted Diseases;social stigma;STI prevention;Surveys;synergism;Syphilis;Syphilis Serodiagnosis;Testing;testing services;therapy development;Training;transmission process;treatment as prevention;trend;Washington;Woman;Work

PROJECT_TITLE: 3T-Prevent: Piloting a multi-level, combination intervention strategy to expand HIV and bacterial STI prevention

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Transgender women are highly burdened by the HIV epidemic in the United States. This proposal will use a novel, technology-infused “community hub”-supported digital cohort (“hub-supported digital cohort”) model to evaluate HIV incidence, syndemic conditions, and risk factors among transgender women in the US and territories (N=3,000). We will refine optimal digital cohort methods to mitigate selection bias, gather 24 months of longitudinal data from transgender women, examine individual and contextual predictors of HIV incidence, and utilize cohort and contextual data to parameterize mathematical models for the identification of effective HIV prevention interventions to change the trajectory of HIV and syndemic conditions among transgender women in the US.

PI_NAMEs: REISNER, SARI ;WIRTZ, ANDREA L (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Address;Adherence;Age;AIDS prevention;Alcohol abuse;Area;Attention;Automobile Driving;Black race;Cessation of life;Cities;Clinical Trials;cohort;Communities;contextual factors;Coupled;Data;Death Rate;demographics;Development;digital;Disease;Disparity;Disproportionately impacts women;distrust;Drug usage;Economics;effectiveness testing;Enhancement Technology;Enrollment;Ensure;Epidemic;Epidemiology;Equity;ethnic diversity;Ethnic Origin;Event;evidence base;Exclusion;experience;follow-up;Formulation;Future;gender affirming care;Health;health disparity;Healthcare;High Risk Woman;HIV;HIV risk;HIV Seronegativity;HIV Seropositivity;Homicide;Hybrids;Imprisonment;Incidence;Individual;Inequity;Intervention;Latinx;literacy;mathematical model;Measures;men who have sex with men;Mental disorders;Mental Health;Methods;Modeling;Monitor;multidisciplinary;multilevel analysis;national surveillance;neglect;novel;Overdose;Participant;Patient Self-Report;Pattern;personalized approach;Persons;Policies;Population;Population Heterogeneity;Populations at Risk;pre-exposure prophylaxis;Prevalence;Prevention;Prevention Research;Prevention strategy;preventive intervention;psychosocial;Race;racial diversity;recruit;Reporting;Research;Research Support;Risk;Risk Factors;Role;Sampling;scale up;Selection Bias;sex;Sister;Site;social;social disparities;Social isolation;structural determinants;substance use;Suicide;syndemic;Technology;Testing;Time;transgender women;trend;Unemployment;United States;uptake;violence victimization;virtual;Vulnerable Populations;Work

PROJECT_TITLE: Enhanced COhort methods for HIV Research and Epidemiology (ENCORE) among transgender women in the United States


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Prevention

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Sudden cardiac death (SCD) associated with ventricular tachycardia or fibrillation is responsible for 50% of deaths in patients with structural heart disease. The implantable cardioverter defibrillator (ICD) is an established therapy for reducing arrhythmic mortality. This study seeks to better define the role of cardiovascular MRI in enhancing SCD risk stratifications in patients with nonischemic cardiomyopathy.

PI_NAMEs: NEZAFAT, REZA  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: 3-Dimensional;Ablation;Animals;Arrhythmia;Biological;Biological Markers;Blood;Cardiac;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;case control;Catheters;Cessation of life;Characteristics;Cicatrix;Clinical;clinical risk;clinically significant;Coronary Arteriosclerosis;cost;Darkness;Data Set;Diffuse;Electrocardiogram;Eligibility Determination;Evaluation;explainable machine learning;extracellular;Fibrosis;Functional disorder;Funding;Gadolinium;Goals;Guidelines;Health Care Costs;Heart;Heterogeneity;Image;imaging biomarker;Implantable Defibrillators;implantation;improved;Individual;insight;Left Ventricular Ejection Fraction;Machine Learning;machine learning model;Magnetic Resonance Imaging;Maps;Measures;Modeling;Morbidity - disease rate;mortality;mortality risk;Multicenter Studies;Myocardium;novel;Patient Selection;Patients;Phenotype;Physiological;primary endpoint;Primary Prevention;prophylactic;prospective;Prospective Studies;radiomics;Recording of previous events;Resolution;Risk;Risk Marker;risk prediction model;risk stratification;Role;Shock;Statistical Models;structural heart disease;sudden cardiac death;Techniques;Technology;Ventricular Arrhythmia;Ventricular Fibrillation;Ventricular Remodeling;Ventricular Tachycardia;voltage

PROJECT_TITLE: Cardiovascular MRI Characterization of the Arrhythmogenic Heart in Nonischemic Cardiomyopathy

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE As economically vulnerable youth living with HIV transition into young adulthood, they experience limited social support and compromised health, including inconsistent adherence to antiretroviral therapy and other health- related regimens, which elevates their vulnerability to virologic failure, poor mental health functioning, cognitive deficits, such as memory and executive functioning and other negative life outcomes, including risk-taking behaviors, leading to HIV transmission. The Suubi+Adherence-R2 study will extend the recently completed efficacious Suubi+Adherence study to examine the longitudinal outcomes related to adherence to HIV antiretroviral therapy (ART) as well as the potential mechanisms of protective health behaviors among youth living with HIV who have previously received an experimental family economic empowerment intervention and are now transitioning into young adulthood in Uganda. Aligned with the National Institutes of Health Office of AIDS Research priorities, the findings of this study may inform efforts to improve HIV care continuum among Uganda’s youth living with HIV, with potential replicability in other low-resource countries.

PI_NAMEs: NABUNYA, PROSCOVIA ;SENSOY BAHAR, OZGE ;SSEWAMALA, FRED M (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Adolescent and Young Adult;Affect;Africa;Africa South of the Sahara;aged;Alcohols;antiretroviral therapy;Area;arm;Behavior;Biological;Caring;Child Development;Child Health;Clinic;Cognition;Cognitive;Cognitive deficits;cognitive development;cognitive function;cognitive testing;comorbidity;comparison control;comparison intervention;Continuity of Patient Care;cost effectiveness;Country;Decision Making;Development;drug misuse;Drug Prescriptions;Economics;empowerment;Enrollment;evidence base;executive function;experience;Failure;Family;Feeling hopeless;Female;financial literacy;Health;Health behavior;high risk;HIV;HIV anti-retroviral;HIV-associated neurocognitive disorder;HIV/AIDS;Home;improved;Incentives;innovation;Intervention;Life;Life Cycle Stages;Long-Term Effects;Maintenance;male;Marriage;medical appointment;Memory;Mental Depression;Mental Health;Mentorship;Outcome;Participant;peer;Pharmaceutical Preparations;Phase;Prevalence;primary outcome;programs;prospective;Prospective Studies;protective factors;psychologic;Randomized;Regimen;Reporting;Research;Research Priority;Resources;Risk;Risk Taking;Running;Rural;Sahara;Savings;Schools;secondary analysis;Self Efficacy;sexual risk taking;social;social stigma;Social support;standard of care;theories;therapy adherence;Training;transmission process;treatment adherence;treatment arm;two-arm study;Uganda;United States National Institutes of Health;Viral;Viral Load result;young adult;Youth

PROJECT_TITLE: Suubi+Adherence-R2: Examining the longitudinal HIV treatment adherence among youth living with HIV (YLHIV) transitioning into young adulthood


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: MANHATTAN

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: PROJECT NARRATIVE The hallmark symptom of Alzheimer's disease (AD) and most common complaint among cognitively healthy older adults is memory loss, especially for everyday events. This project will evaluate the extent to which older adults use semantic knowledge to create stable mental representations during the continuous stream of everyday experiences, and whether this ability changes in the early stages of AD.

PI_NAMEs: BAILEY, HEATHER  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Age;age difference;age related;age related decline;Alzheimer's Disease;Behavior;Behavioral;Brain;Brain region;Caregivers;Cognitive;Communities;Complex;Cortical Synchronization;Coupling;Cues;disability;Electroencephalography;Episodic memory;Event;experience;Failure;Family;Friends;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Goals;Grain;Health;Healthcare;healthy aging;Hippocampus;improved;indexing;Individual;innovation;insight;Knowledge;knowledge of results;Laboratories;Learning;Life;Link;long term memory;loved ones;Maintenance;Measures;Medial;Mediating;member;Memory;Memory Loss;mental representation;Methods;Mission;Modeling;Nature;neuroimaging;neuromechanism;neurophysiology;Neuropsychology;new technology;novel;novel strategies;older adult;Organism;Pattern;Perception;Performance;Persons;Prefrontal Cortex;preservation;Process;process improvement;Psyche structure;Quality of life;recruit;Reporting;Research;Research Personnel;Retrieval;Role;Sampling;scaffold;Science;Semantic memory;Semantics;Shapes;spatiotemporal;Stimulus;Stream;Structure;Support System;Symptoms;Testing;United States National Institutes of Health;Update;Vision;Work;young adult

PROJECT_TITLE: The role of prior knowledge and event segmentation in age- and Alzheimer's-related changes in event memory


NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: Public Health relevance: Pain and addiction are interdependent, chronic, and relapsing disorders that cause an enormous burden on society. Identifying targets to develop non-addictive analgesics is of great relevance to public health. This proposal addresses fundamental questions underlying barriers in developing the delta opioid receptor as a target for pain management.

PI_NAMEs: PUTHENVEEDU, MANOJKUMAR A (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: addiction;addiction liability;Address;Adverse effects;Agonist;Analgesics;Animal Model;beta-2 Adrenergic Receptors;Binding;Biochemical;Biological Assay;Biology;Biosensor;Brain region;C-terminal;Cell Line;Cell membrane;Cell surface;Cell Surface Receptors;Cells;Central Nervous System;Chronic;clinically relevant;common symptom;comorbidity;Complement;Convulsions;CRISPR screen;delta opioid receptor;Disease;Dose;Effectiveness;experimental study;extracellular;Family;Foundations;Future;G-Protein-Coupled Receptors;Genetic;Genetic Transcription;genome-wide;Goals;Golgi Apparatus;GTP-Binding Proteins;Hospitals;Image;in vivo;Intracellular Membranes;Location;Measures;Mechanics;Mediating;Methods;Modality;Modeling;Molecular Conformation;mouse model;mu opioid receptors;neural circuit;Neurons;Neurotransmitter Receptor;novel;novel strategies;Opiate Addiction;Opioid;Opioid agonist;Opioid Analgesics;opioid epidemic;Opioid Receptor;Outcome;Pain;pain inhibition;Pain management;Pain Measurement;pain reduction;Pathway interactions;Peripheral Nervous System;Pharmaceutical Preparations;pharmacologic;Phospholipids;Physiological;Physiology;protein activation;Proteins;Public Health;public health relevance;receptor;Receptor Activation;receptor function;Receptor Signaling;Relapse;Reporting;response;Rewards;Role;side effect;Signal Pathway;Signal Transduction;Societies;Surface;System;Tail;Testing;tool;trafficking;Validation

PROJECT_TITLE: Regulated trafficking and compartmentalized signaling of opioid receptors

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: DENVER

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF DENVER (COLORADO SEMINARY)

ORG_STATE: CO

PHR: 8. Project Narrative  The proposed project is relevant to public health because it will develop and validate technology to detect ethylene as a unique biomarker of oxidative stress. Ethylene is a product of lipid peroxidation and in-turn a measure of oxidative stress, which is related to numerous diseases. The development of sensitive fluorescent probes could broaden the study of the biological production and role of ethylene, which is in line with the mission of the National Institute of General Medical Sciences (NIGMS). 1

PI_NAMEs: MICHEL, BRIAN  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Alkenes;Biological;Biological Markers;biological systems;BODIPY;Carbon Monoxide;Cardiovascular Diseases;catalyst;Detection;detection limit;Development;Disease;Environment;Ethylenes;Exhalation;Fluorescent Probes;Growth;improved;insight;interdisciplinary approach;interest;Ligands;Lipid Peroxidation;Lipid Peroxides;Location;Malignant Neoplasms;Mammals;Measures;metalloenzyme;Methods;Mission;Modification;Molecular Probes;National Institute of General Medical Sciences;Neurodegenerative Disorders;novel strategies;Oxidative Stress;Plant Growth Regulators;Play;Production;programs;Public Health;Reaction;Reaction Time;Reactive Oxygen Species;Reporting;Research;Resolution;response;Role;Ruthenium;Sampling;sensor;Signal Transduction;small molecule;Stress;Technology;technology validation;Transition Elements;Work

PROJECT_TITLE: Organometallic Sensors for Cellular Small Molecule Detection

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Nutrition;Obesity;Prevention

PHR: Project Narrative. Metabolic and bariatric surgery is currently the most effective treatment for severe obesity; however, a substantial proportion of patients attain suboptimal weight losses and continue to struggle with obesity, weight regain, and related medical comorbidities after surgery. Thus, this study aims to perform a randomized double- blind placebo-controlled study to test the effectiveness of a rigorous manualized behavioral weight loss treatment and a FDA-approved weight loss agent (naltrexone+bupropion), alone and in combination, for improving weight loss, cardiovascular risk factors, and psychosocial functioning after metabolic and bariatric surgery. This study will produce important new clinical findings regarding the utility and effectiveness of pharmacotherapy and behavioral weight loss for a rapidly growing obesity subgroup and will inform care models for managing chronic and refractory obesity to enhance outcomes after metabolic and bariatric surgery.

PI_NAMEs: IVEZAJ, VALENTINA  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Acute;Adopted;Adult;Aftercare;bariatric surgery;Behavior Therapy;Behavioral;Body mass index;Body Weight decreased;Bupropion;burden of illness;cardiometabolic risk;cardiovascular risk factor;Caring;Chronic;Clinical;Clinical Research;Combined Modality Therapy;Combined Pharmacological and Behavioral Treatment;comorbidity;craving;Data;depressive symptoms;design;Dietary intake;Double-Blind Method;Eating;Eating Disorders;Economic Burden;effective therapy;Effectiveness;effectiveness evaluation;effectiveness testing;Evidence based treatment;FDA approved;follow up assessment;food craving;Future;Gastrectomy;Gastric Bypass;Glucose;Glycosylated hemoglobin A;Guidelines;Health Care Costs;improved;Individual;Insulin;Lipids;Longterm Follow-up;Manuals;Mediator;Medical;Metabolic;Modeling;Moods;Morbid Obesity;Naltrexone;Neck;obese patients;Obesity;obesity treatment;Operative Surgical Procedures;Outcome;Outcome Assessment;patient oriented;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Physical activity;placebo controlled study;Placebos;primary outcome;Prospective Studies;Psychopathology;psychosocial;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Recurrence;Refractory;Risk;Risk Factors;Stratification;Subgroup;symptomatology;Testing;treatment effect;United States National Institutes of Health;Weight;weight loss intervention;Weight-Loss Drugs

PROJECT_TITLE: Behavioral and Pharmacological Treatments to Enhance Weight Outcomes after Metabolic and Bariatric Surgery

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: PITTSBURGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE High blood pressure is a major risk factor for strokes and heart attacks. However, hypertension is difficult to be diagnosed from blood pressure measurement in the clinics and is often undetected. Research will be performed to develop wearable technology for non-invasive, continuous blood pressure monitoring.

PI_NAMEs: XIONG, FENG  (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Accelerometer;Achievement;Address;Adhesions;Age;Ambulatory Blood Pressure Monitoring;arterial tonometry;Blood Pressure;Blood Pressure Monitors;Calibration;Cardiovascular Diseases;cardiovascular risk factor;Clinic;Clinical;clinical practice;covalent bond;crosslink;design;Devices;Diagnosis;Diastolic blood pressure;Distal;Effectiveness;Electrocardiogram;Ethnic Origin;foot;Gender;Generations;Geometry;Heart;Hour;Human;human subject;Hypertension;hypertensive;Hypotension;improved;innovation;Ions;Liquid substance;Measurement;Measures;Methods;Monitor;monitoring device;Morphologic artifacts;mortality;Myocardial Infarction;Noise;normotensive;novel;operation;Outcome;Patients;Periodicals;Photoplethysmography;Physiologic pulse;Postural adjustments;pressure;Research;Risk Factors;sensor;Shapes;Signal Transduction;Site;Skin;Sleep;Stroke;Structure;Supination;Surface;System;Systems Integration;Technology;temporal measurement;Time;Translating;Travel;wearable device;wearable sensor technology;wireless;Work

PROJECT_TITLE: Wearable Micro-Structured Tonometric Sensor Patches for 24-Hour Ambulatory Blood Pressure Monitoring

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

PHR: Project Narrative This research addresses the need to eradicate sexual harassment and racially motivated mistreatment of graduate students and post-doctoral fellows in biomedical research training programs so that women and racial/ethnic minoritized students can thrive and contribute to scientific discovery. We examine the role of mentors’ power on their proclivity to sexually and racially harass and exacerbated by power-based structural elements of the training environment, and we develop a comprehensive intervention to dismantle those forces.

PI_NAMEs: KIMBLE-HILL, ANN CAROL;STOCKDALE, MARGARET S (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Accountability;Address;Affect;Affective;Antidotes;Authorship;Behavior;Behavioral;Behavioral Sciences;Biomedical Research;Brassicaceae;career;Characteristics;Climate;climate change;Cognition;cohort;Collaborations;combat;Data;Demographic Factors;Demography;design;Development;Elements;emotional distress;Emotions;Empathy;Environment;Equity;ethnic minority;Exclusion;experience;Faculty;Fellowship;Female;Gender;Goals;graduate student;Grant;harassment;improved;In Situ;Incidence;Indiana;Individual;Inequity;insight;Institution;Intervention;Knowledge;Lead;Licensing;Link;maltreatment;Manuscripts;marginalization;Measures;Medical;Mentors;Mentorship;Methodology;microaggression;Minority;minority student;minority trainee;Morals;Nature;Organizational Change;Outcome;Pathway interactions;Pattern;Personality Character;Persons;perspective taking;Postdoctoral Fellow;prevent;Professional Practice;programs;Race;racial minority;Randomized;Records;Reporting;Research;Research Training;response;Role;Sampling;Science;Scientific Advances and Accomplishments;sex;Sexual Harassment;social exclusion;Students;success;Surveys;Talents;Testing;theories;Training;Training Programs;United States National Institutes of Health;White Women;Woman;workforce needs

PROJECT_TITLE: Indiana CARES (Creating Accountability and Building Relationships to Eradicate Sex Harassment)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Pediatric;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant bleeding disorder of dysregulated angiogenesis with no FDA-approved treatments. This project will determine the efficacy of systemic bevacizumab to treat chronic bleeding and anemia in HHT through a phase II clinical trial, assessing the impact of therapy on red cell transfusion needs, iron infusion needs, and quality of life. By prospectively demonstrating the efficacy of systemic bevacizumab to reduce bleeding and improve quality of life, this project will address a significant unmet clinical need for patients with this relatively common hereditary bleeding disorder.

PI_NAMEs: AL-SAMKARI, HANNY T (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Adult;Affect;Anemia;angiogenesis;Angiogenesis Inhibitors;arm;autosome;bevacizumab;Biological Markers;Blood Coagulation Disorders;Blood Transfusion;career development;Caring;Characteristics;Chronic;Clinical;Clinical Investigator;Clinical Trials;Control Groups;Correlative Study;Data;Dependence;design;Development;Development Plans;Disease;Dose;drug repurposing;efficacy evaluation;Environment;Epistaxis;Erythrocytes;FDA approved;Functional disorder;Future;Gastrointestinal Hemorrhage;Goals;Gut Mucosa;health related quality of life;Hematology;Hemoglobin;Hemorrhage;Hemostatic function;Hereditary hemorrhagic telangiectasia;Heterogeneity;Hour;Human;improved;Information Systems;Infusion procedures;Inherited;innovation;instrument;International;Iron;Iron deficiency anemia;Knowledge;Label;Learning;Measurement;Measures;Mentors;Mentorship;Monoclonal Antibodies;Morbidity - disease rate;mortality;neoplastic;novel;Observational Study;Oncology;Outcome;Patient Outcomes Assessments;Patients;Persons;Pharmaceutical Preparations;pharmacodynamic biomarker;Phase II Clinical Trials;Physicians;primary endpoint;prospective;Qualifying;Quality of life;Recurrence;Regimen;Research;Research Personnel;Research Project Grants;Residual state;response biomarker;Science;Scientist;secondary endpoint;Secondary to;Severities;Social isolation;standard care;Standardization;Structure of mucous membrane of nose;success;synergism;System;Systemic Therapy;Telangiectasis;Time;tool;Transfusion;Travel;treatment duration;United States National Institutes of Health;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Antiangiogenic Therapy to Reduce Bleeding and Improve Health-Related Quality of Life in Hereditary Hemorrhagic Telangiectasia

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative We will characterize the serum autoantibody profiles of 1,300 subjects who belong to three large, well-phenotyped cohorts across the spectrum of disease severity and COVID variants. We will also elucidate the role of Fc glycosylation and impairments in the establishment of B cell tolerance in the development of autoantibodies in COVID-19. Our analysis may lead to a paradigm shift in our understanding of the immune and autoimmune responses during COVID-19 as well as viral infections and critical illness more broadly.

PI_NAMEs: MEFFRE, ERIC ;ROGERS, ANGELA J (contact);UTZ, PAUL JOSEPH;WANG, TAIA

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;acute COVID-19;acute infection;Acute Respiratory Distress Syndrome;Address;Antibodies;Antibody Repertoire;Antigen-Antibody Complex;Antigens;Authorization documentation;Autoantibodies;Autoantibody binding;Autoantigens;Autoimmune;Autoimmune Responses;Autoimmunity;autoreactive B cell;autoreactivity;B-Lymphocytes;Binding;Cell secretion;Clinical;Clinical Data;cohort;Communicable Diseases;Connective Tissue;Connective Tissue Diseases;Convalescence;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 patient;Critical Illness;cytokine;Defect;Dengue Virus;Development;Disease;Emigrant;Evolution;Fc domain;Follow-Up Studies;Frequencies;Generations;glycosylation;Goals;Hospitalization;humanized mouse;IgG autoantibodies;Immune;Immune response;Immune System Diseases;Immunoglobulin G;Immunologics;Immunology;immunoregulation;Impairment;Infection;Inflammation;Inflammatory;Inflammatory Response;Interferon Type I;Intervention;Lung;Mass Spectrum Analysis;Measurement;Methods;Molecular;multidisciplinary;Natural experiment;Outcome;Pathogenicity;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Pneumonia;Population;Predisposition;Production;Property;Pulmonology;receptor;Recontacts;Regulation;Resources;Rheumatology;Role;Sampling;Sampling Studies;SARS-CoV-2 infection;SARS-CoV-2 variant;Serum;severe COVID-19;Severity of illness;Structure;System;Testing;Time;Viral;Virus Diseases;Work

PROJECT_TITLE: Elucidating the immunology of autoantibody formation and function in COVID-19

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Epilepsy;Genetics;Headaches;Migraine;Neurodegenerative;Neurosciences;Pain Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative  Epilepsy affects approximately 1% of the population in the USA and migraine affects approximately 12%, and for reasons that are not entirely clear these two disorders are often found to be co-morbid. The astrocytic receptor GPR37L1 has been linked in human genetic studies to both epilepsy and migraine, and this project seeks to elucidate the cellular and mechanistic basis by which this receptor regulates seizure and migraine susceptibility. These studies will shed light on the fundamental biology of GPR37L1 and provide insights that will allow for the eventual targeting of this receptor to create novel therapies for epilepsy, migraine and other diseases.

PI_NAMEs: HALL, RANDY A. (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acute;Address;Affect;Astrocytes;Binding;Biology;Brain;brain tissue;comorbidity;Data Set;Development;Disease;Epilepsy;Exhibits;exome;experimental study;Family;Follow-Up Studies;Functional disorder;G-Protein-Coupled Receptors;Genetic;Genetic study;Genetic Variation;Goals;GTP-Binding Proteins;Human;Human Biology;human disease;Human Genetics;human induced pluripotent stem cells;Hyperalgesia;insight;Knock-in Mouse;Link;Migraine;Migraine Variants;Modeling;Mus;Mutant Strains Mice;Nitroglycerin;novel;novel therapeutics;Organoids;Pathogenicity;Pathology;Patients;Pharmacology;Phenotype;Physiological;Physiology;Play;Population;Predisposition;Process;Progressive Myoclonic Epilepsies;Property;Protein Secretion;Proteomics;receptor;receptor function;Risk;Rodent Model;Role;Scaffolding Protein;segregation;Seizures;Signal Transduction;Spreading Cortical Depression;targeted treatment;Testing;trafficking;Transcript;transcriptome sequencing;Variant;Wild Type Mouse;Work

PROJECT_TITLE: Control of Seizure and Migraine Susceptibility by GPR37L1

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative The immune system represents as a powerful tool to protect multicellular organisms from existential threats, such as microbial infection and cancer, yet the best ways to generate protective immunity remain unclear. Our research proposal sets out to understand the means by which an immune response is set into motion to stimulate the most effective protective inflammatory responses. By focusing our work on cells that act very early in the immune reactions, we may unravel new means by which we can control adaptive immune responses to ensure organismal health.

PI_NAMEs: KAGAN, JONATHAN C (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: adaptive immune response;Address;Amino Acids;Bioinformatics;Biology;cancer cell;Catalytic Domain;CD8-Positive T-Lymphocytes;cell mediated immune response;Cell Physiology;cell type;Cells;Clinical;comparative;Complex;Cyclic GMP;cytokine;Data;Detection;Discrimination;Disease;Disease Progression;DNA;DNA Binding;Ensure;Enzymes;Event;expectation;Genetic;Goals;Health;Human;Immune response;Immune system;Immunity;immunoreaction;Implant;In Vitro;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Interferons;Macrophage;Malignant Neoplasms;Mediating;microbial;Motion;Mus;mutant;Nature;Organism;Outcome;Pan Genus;Pathway interactions;Physiological;Play;Pongo pygmaeus;Pre-Clinical Model;Primates;protein function;Proteins;Regulation;Regulatory Element;Reporting;Research Proposals;Resolution;response;Role;scaffold;Second Messenger Systems;Sensory;Signal Transduction;small molecule;Source;Specific qualifier value;Stimulator of Interferon Genes;Sugar Phosphates;synthetic biology;System;T-Lymphocyte;Tissues;tool;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;Vertebral column;virtual;Work

PROJECT_TITLE: Regulation of immunity by the cGAS-STING pathway

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD)

ORG_CITY: MENLO PARK

ORG_NAME: MARTINEAU & ASSOCIATES

PHR: Project Narrative  Innovation in zebrafish welfare needs to keep up with the increasing use of this animal model of human disease for impactful medical research. Using a revolutionary imaging technology called Remanent Imaging, the proposed “CanaryTank” system will directly plug into existing husbandry facilities and video monitor the behavior of sentinel fish populations to detect threats to their health and wellbeing. By monitoring a wide range of crucial factors neglected by current systems, CanaryTank will realize a giant leap forward in securing the health and wellbeing of medical research zebrafish, a paramount concern and unmet need as the rigor and repeatability of research depends on them.

PI_NAMEs: MARTINEAU, PIERRE R. (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: 3-Dimensional;Adopted;Adult;Algorithms;Animal Behavior;animal colony;Animal Model;Animal Welfare;Animals;Anxiety;Architecture;Autopsy;Behavior;behavior change;Behavior monitoring;Behavioral;blind;Classification;Code;Collection;commercialization;Communities;Complex;Computer software;Computer Vision Systems;Custom;Darkness;dashboard;Data;data access;design;Detection;Diagnosis;diagnostic algorithm;Disease;Electronic Mail;Environment;environmental change;Ethics;Event;experimental study;Feedback;feeding;Fishes;Frequencies;Funding;Future;Grant;Health;Health Status;Health system;human disease;human model;Human Resources;Hunger;Image;Imaging technology;improved;innovation;International;invention;Laboratories;Larva;Lasers;Legal patent;Light;Machine Learning;manufacture;Marketing;Measurable;Measures;Medical Research;millisecond;Mind;model organism;Monitor;Movement;Names;neglect;Optics;Outcomes Research;Pattern;Pattern Recognition;Personal Satisfaction;Phase;Plug-in;Population;Process;prototype;Quality Control;Reaction;Records;Recurrence;Reporting;Reproducibility;Research;Research Project Grants;Resources;Secure;Sentinel;Services;Side;Site;Sleep;Standardization;Stream;success;Swimming;System;Techniques;Technology;Temperature;temporal measurement;Testing;Time;United States National Institutes of Health;Vendor;Vision;Water;water flow;water quality;welfare;Zebrafish

PROJECT_TITLE: CanaryTank: a plug-in husbandry behavior tracking system for health of fish facilities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative This proposal describes a series of experiments to test a potential causal link between L1s retrotransposons and Alzheimer's Disease (AD) using a human model system. The outcome of this study will increase our understanding of AD and will generate novel insights on disease mechanism, opening opportunities for improved therapies.

PI_NAMEs: MUOTRI, ALYSSON R. (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Acceleration;age effect;Aging;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Astrocytes;Autopsy;Biological Models;Brain;brain cell;Cell Aging;Cell Death;cell type;Cells;Chronic;Collection;CRISPR/Cas technology;cytokine;Cytoplasm;Data;design;Disease;Disease Progression;DNA;Elements;Evolution;experimental study;Gene Expression;Genome;Genomics;Goals;Human;human disease;human model;human tissue;Immune system;Immunologic Stimulation;improved;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;insight;Interferon Activation;Interferons;L1 Elements;Link;Measures;Microglia;Modeling;Molecular;mutant;neural network;Neuroglia;Neurons;neurotoxic;neurotoxicity;novel;Nucleosides;Organoids;Outcome Study;overexpression;Pathogenesis;Pathway interactions;Phenotype;premature;Protective Agents;Protocols documentation;response;Retrotransposon;Reverse Transcriptase Inhibitors;Reverse Transcription;RNA-Directed DNA Polymerase;Series;Single-Stranded DNA;Site;Sterility;Synapses;synaptogenesis;Syndrome;tau aggregation;tau-1;Testing;Therapeutic;transcriptomics;whole genome

PROJECT_TITLE: Establishment of a causal link between AD and L1 retrotransposons


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The UW 4D Genome Organization of Mammalian Embryogenesis Center (UW 4D GENOME) aims to elucidate chromatin dynamics during the early stages of mammalian development. Accordingly, the proposed center will carry out systematic generation of sequencing and imaging data during mouse embryogenesis, summarizing and visualizing the resulting data using machine learning models. These approaches will also be applied to investigate nuclear architecture in mouse models with mutations in genes relevant to nuclear structure, which will help advance our understanding of diseases such as laminopathy and cancer.

PI_NAMEs: DISTECHE, CHRISTINE M.;NOBLE, WILLIAM STAFFORD (contact);SHENDURE, JAY ASHOK

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 3-Dimensional;Alleles;Antibodies;Architecture;ATAC-seq;Atlases;Biological Assay;C57BL/6 Mouse;Cell Line;Cell Nucleolus;Cell Nucleus;Cell Separation;cell type;Cells;Chromatin;Chromatin Structure;Chromosomes;Communities;Data;Data Collection;Data Set;data visualization;Development;Disease;DNA;Embryo;Embryonic Development;Emerging Technologies;Four-dimensional;Gene Expression;Gene Mutation;Generations;Genes;Genetic Transcription;Genome;Genomics;Goals;Heterochromatin;Hi-C;Hour;Human;human data;human disease;Hybrids;Image;imprint;In Vitro;in vivo;interactive visualization;knowledge translation;lamin B receptor;Lamin Type A;machine learning model;Malignant Neoplasms;Mammalian Cell;Maps;Measurement;Methods;model organism;Modeling;Molecular;Molecular Conformation;molecular phenotype;Molecular Profiling;Morphology;mouse development;mouse model;Mus;mutant;Mutation;novel;Nuclear;Nuclear Structure;nucleophosmin;Pathway interactions;Phenotype;Positioning Attribute;Resolution;RNA;Series;Shapes;single cell ATAC-seq;single-cell RNA sequencing;Sorting;Stains;Statistical Methods;System;Time;Tissues;transcriptome sequencing;Universities;Visual;Visualization;Washington;web portal;Whole Organism;X Inactivation

PROJECT_TITLE: UW 4-Dimensional Genomic Organization of Mammalian Embryogenesis Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(50)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Rehabilitation

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Cognitive decline in Parkinson disease (PD) causes disability and reduced quality of life. Current medical treatments do not prevent or treat cognitive decline in PD, so behavioral interventions that mitigate its negative functional consequences and thus potentially delay the onset of dementia are in high demand. This study will test the efficacy of a targeted training approach for improving cognition and daily function in people with PD and may ultimately result in enhanced independence and quality of life for this population.

PI_NAMEs: FOSTER, ERIN  (contact)

PROJECT_TERMS: Address;Alzheimer's disease related dementia;Attention;Attenuated;behavior prediction;behavior test;Behavior Therapy;Behavioral;Behavioral Mechanisms;Biological;Brain;Brain Injuries;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive impairment in Parkinson's;cognitive process;cognitive rehabilitation;cognitive task;computerized;coping;daily functioning;Data;Dementia;design;disability;Dopamine;Educational Intervention;Educational process of instructing;efficacy evaluation;efficacy testing;Employment;Evaluation;executive function;Expectancy;Fostering;functional decline;Functional disorder;Functional impairment;functional outcomes;Future;Goals;Health behavior;Health Care Costs;Impaired cognition;Impairment;improved;Independent Living;informant;Infrastructure;Intention;Intervention;Intervention Studies;Laboratories;Lateral;Life;Longitudinal cohort;Magnetic Resonance Imaging;Measures;Medical;member;Memory;Memory impairment;Mental Depression;mild cognitive impairment;Monitor;mortality;Motivation;Motor;multilevel analysis;neural;neural correlate;neurobiological mechanism;neuroimaging;Neurologic;neuromechanism;novel;Operative Surgical Procedures;Parents;Parkinson Disease;Parkinson's Dementia;Participant;Pattern;Performance;Persons;Pharmaceutical Preparations;pharmacologic;Population;Populations at Risk;predicting response;Prediction of Response to Therapy;Prefrontal Cortex;primary endpoint;Process;programmed cell death protein 1;prospective memory;Psychological Transfer;Quality of life;Randomized;Randomized, Controlled Trials;Regression Analysis;repetitive task practice;Reporting;Research;Research Personnel;Research Priority;response;Rest;Retrieval;secondary endpoint;Single-Blind Study;social relationships;Standardization;Stroke;Testing;tool;Training;Training Programs;treatment response;trial comparing;Work

PROJECT_TITLE: Prospective memory impairment in Parkinson disease-related cognitive decline: Intervention and mechanisms

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Childhood Injury;Diabetes;Pediatric;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_DEPT: ORTHOPEDICS

ORG_NAME: YALE UNIVERSITY

PHR: Narrative The proposed studies will provide a better understanding of growth factor and cytokine in diabetic fracture healing. The proposal will also develop an injectable hydrogel loaded with an unique osteoinductive factor with anti-inflammatory activity for treating diabetic fracture. Identification of novel molecules and their derivatives relevant to diabetic fracture healing may provide the basis for developing and optimizing the application of the novel therapeutic targets in diabetic and many other impaired fracture healing.

PI_NAMEs: LIU, CHUANJU  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: 3D Print;Affinity;Anti-Inflammatory Agents;Autoimmune;Autoimmune Diseases;Binding;Biochemical;bone fracture repair;bone healing;Bone Marrow Stem Cell;Bone Regeneration;Bone Resorption;Cell Separation;Chondrogenesis;Chronic;Complex;Consensus;CRISPR/Cas technology;cytokine;Data;Dependence;Development;Diabetes Mellitus;diabetic;diabetic patient;Disease;dosage;Effectiveness;Event;Exhibits;Force of Gravity;Fracture;Gene set enrichment analysis;Genes;Genetic;Genetic Screening;Growth Factor;Hydrogels;Impaired healing;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Arthritis;Inflammatory Response;inhibitor;Injectable;Injections;Insulin-Dependent Diabetes Mellitus;interest;Knock-out;Knockout Mice;Laboratories;Ligands;Maleimides;Mass Spectrum Analysis;Mediating;Modeling;Molecular;Mus;Names;new therapeutic target;novel;novel therapeutic intervention;Open Fractures;Osteogenesis;osteoinductive factor;Pathway interactions;PGRN gene;Pilot Projects;Play;Polyethylene Glycols;prevent;protective effect;Protein Engineering;receptor;Receptors, Tumor Necrosis Factor, Type II;Recombinants;recruit;regenerative;Regenerative pathway;response;Risk;Role;scaffold;Science;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Streptozocin;Testing;Therapeutic;TNF gene;TNFRSF1A gene;TNFRSF1B gene;treatment effect;Treatment Efficacy;Tumor Necrosis Factor Receptor

PROJECT_TITLE: Targeting TNF Receptors to Inhibit Inflammation and to Prompt Bone Regeneration in Type 1 Diabetes

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE (OVERALL) The overarching mission of the Rose F. Kennedy IDDRC (RFK IDDRC) is to improve the lives of children with intellectual and developmental disabilities (IDD) through research and clinical outreach. This will be realized through Center-sponsored support of collaborations between bench scientists and clinicians at Einstein and Montefiore, and with other IDDRCs and related institutions; and with the support of four scientific Cores. In addition, the Center will advance understanding of the biological pathways responsible for IDD in children as a result of mutations in KDM5C through a multi-investigator/multimodal research project.

PI_NAMEs: MOLHOLM, SOPHIE  (contact);WALKLEY, STEVEN UPSHAW

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Advocate;Affect;Animal Behavior;animal tissue;Animals;arm;autism spectrum disorder;Basic Science;Biological;Biology;brain cell;cellular engineering;cellular imaging;Charge;Child;Clinic;Clinical;clinical care;clinical phenotype;Clinical Research;clinical training;clinical translation;Collaborations;college;Communities;Community Outreach;cost effectiveness;Coupled;Dedications;design;developmental disease;Diagnosis;DiGeorge Syndrome;Disability research;Disease;Disorder of neurometabolic regulation;Early Diagnosis;Educational workshop;Epigenetic Process;Evaluation;Faculty;Faculty Recruitment;Family;forging;Fortification;Fostering;Funding;Ganglia;Genes;Genetic Transcription;Genomics;Goals;Grant;Head;Hospitals;Human;Human Resources;human tissue;Image;imaging facilities;improved;Infant;Infantile spasms;innovation;insight;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Laboratory Research;Leadership;Link;Lysine;Medical;Medical center;Medicine;member;Metabolism;Mission;Monitor;multidisciplinary;multimodality;Mutation;National Institute of Child Health and Human Development;Neonatal Screening;Neurodevelopmental Disorder;Neurofibromatoses;neurogenomics;Neurons;Newsletter;next generation;novel;Online Systems;operation;Outcome;outreach;outreach program;Participant;Pathogenesis;Pathway interactions;Patient Care;Patients;Pediatric Hospitals;Phenotype;Postdoctoral Fellow;precision medicine;prevent;programs;Quality Control;Recruitment Activity;Rehabilitation Centers;Research;Research Personnel;Research Project Grants;research study;Rett Syndrome;Role;Science;Scientist;screening program;Services;Solid;Structure;Students;symposium;Talents;Technology;Time;tool;Training;Training Programs;Translating;Translational Research;Tuberous Sclerosis;Universities;Visualization;Williams Syndrome

PROJECT_TITLE: SUPPORT FOR THE ROSE F KENNEDY IDDRC P50


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE This project will provide data and sequence on an additional 6,600+ individuals to increase the diversity of the and sample sets in the Alzheimer's Disease Sequencing Project (ADSP), creating an invaluable resource for the Alzheimer's disease (AD) research community at large. These efforts will speed discoveries of targets for AD diagnosis, prevention, and treatment.

PI_NAMEs: CUCCARO, MICHAEL L;KUNKLE, BRIAN WILLIAM;VANCE, JEFFERY MARVIN (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Address;adjudication;African American;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Amish;Autopsy;Blood;cell repository;Classification;Clinical Data;clinical phenotype;Clinical Trials;clinically relevant;Cognitive;cohort;Collaborations;Communities;County;Data;Data Element;Data Set;Dementia;design;Diagnostic;diverse data;DNA;Early Onset Alzheimer Disease;Elderly;endophenotype;ethnic diversity;Ethnic Population;exome sequencing;Faeroe Islands;Follow-Up Studies;Funding;gene discovery;Genes;Genetic;genetic risk factor;Genetic study;genetic variant;Genetic Variation;Genome;genome sequencing;genome-wide;Genotype;health disparity;Hispanic;Hispanic Populations;human genomics;improved;Individual;Knowledge;Large-Scale Sequencing;Methods;novel;Participant;Phase;Phenotype;phenotypic data;Population;Prevention;Process;Production;protective allele;Quality Control;racial diversity;racial population;Research;Resources;risk variant;Sampling;screening;Series;SNP array;Special Population;Speed;Technology;Underserved Population;Variant;whole genome;Work

PROJECT_TITLE: Additional Sequencing for the Alzheimer's Disease Sequencing Project (ADSP)

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Brain Disorders;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: WALKLEY, STEVEN UPSHAW (contact)

PROJECT_TERMS: Address;Advisory Committees;Advocacy;Animals;arm;Basic Science;Black race;Budgets;cellular engineering;cellular imaging;Child;Clinic;Clinical;clinical phenotype;Clinical Research;Collaborations;college;Communication;Communication impairment;Communities;Community Outreach;cost effectiveness;Coupled;Disability research;Disease;Educational workshop;Effectiveness;Ensure;Evaluation;Event;Faculty Recruitment;Family;Family Physicians;Feedback;Fostering;Funding;Gene Expression;Genes;Goals;graduate student;Grant;Hispanic;Hospitals;Human;Human Resources;Inequity;Infrastructure;innovation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;International;Leadership;Link;Medical center;Medical Students;Medicine;meetings;member;Mentors;minority children;Minority Participation;Mission;Modernization;Monitor;Mutation;neurogenomics;Neurons;Newly Diagnosed;Newsletter;next generation;operation;outreach;participant enrollment;Pediatric Hospitals;Phenotype;Pilot Projects;Play;Population;post-doctoral training;Postdoctoral Fellow;Poverty;precision medicine;Procedures;programs;Publications;Quality Control;Rare Diseases;recruit;Recruitment Activity;Rehabilitation Centers;Research;Research Personnel;Research Project Grants;Resources;Role;scaffold;Scientist;social media;Strategic Planning;success;Supervision;Surveys;symposium;System;Training;Training Programs;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Vision;web site;Work

PROJECT_TITLE: ADMIN CORE


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Despite advances in surgery, imaging and therapy, patients with the most common malignant primary brain tumor in adults, glioblastoma, have a dismal prognosis. The proposed research aims to develop novel and effective treatments for glioblastoma by targeting the bromodomain of the BRG1 subunit of the SWI/SNF chromatin remodeling complex. Defining how in glioblastoma cells the bromodomain BRG1 modifies cancer stemness, therapeutic sensitivity and tumorigenicity, while also demonstrating the feasibility of targeting this epigenetic reader as a novel therapeutic approach for treating glioblastoma.

PI_NAMEs: MILLER, DUANE D;PFEFFER, LAWRENCE MARC (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Adult;Alkylating Agents;analog;anti-cancer;ATPase Domain;Binding;Biological;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier penetration;brahma;Brain;Bromodomain;cancer cell;candidate identification;Catalytic Domain;Cell Differentiation process;Cell Line;Cell Maintenance;Cells;chemotherapy;Chromatin;chromatin immunoprecipitation;Chromatin Modeling;Chromatin Remodeling Factor;Clinical;Complex;Coupled;DNA;Drug Design;effective therapy;Epigenetic Process;Foundations;Future;Gene Expression;Generations;Genes;genetic signature;Genetic Transcription;Glioblastoma;Goals;histone modification;Histones;Human;Image;Immune;Immune response;Immunocompetent;Immunocompromised Host;immunoreactivity;improved;In Vitro;in vivo;Inflammatory;inhibitor;innovation;Interferons;knock-down;Knock-out;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;malignant phenotype;Mediating;Modeling;Molecular;Molecular Target;mouse model;multidisciplinary;Mus;mutant;Necrosis;neoplastic cell;next generation;novel;novel therapeutic intervention;Operative Surgical Procedures;Pathway interactions;patient prognosis;Patients;Penetrance;Pharmaceutical Preparations;pharmacologic;Phenotype;Positioning Attribute;prevent;Primary Brain Neoplasms;Prognosis;programs;Property;Reader;Recurrent tumor;Reducing Agents;Research;Resistance;response;RNA Polymerase II;Role;small molecule;SMARCA4 gene;stem;stem cell self renewal;stem cells;stemness;Structure;Surface;SWI/SNF Family Complex;targeted treatment;temozolomide;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;transcriptome;transcriptome sequencing;tumor;tumor microenvironment;tumorigenesis;Tumorigenicity;Work

PROJECT_TITLE: Therapeutic targeting of the SWI/SNF chromatin remodeler to regulate GBM chemosensitivity

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Autism;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Racial and Ethnic Minority Health Research

PI_NAMEs: MOLHOLM, SOPHIE  (contact)

PROJECT_TERMS: Advertisements;Affect;African;African ancestry;Attention deficit hyperactivity disorder;autism spectrum disorder;Brain imaging;Caribbean region;Catchment Area;central database;Characteristics;Child;Clinic;Clinical;Clinical assessments;clinical center;clinical diagnosis;clinical phenotype;Clinical Research;clinical translation;cognitive function;cognitive testing;Collaborations;Communities;Community Outreach;Community Relations;cost;Cost effectiveness research;Data;data acquisition;Data Analyses;Databases;Development;Developmental Disabilities;developmental disease;Diagnosis;Diagnostic;Disability research;Enrollment;Ensure;ethnic diversity;Exposure to;Family;follow-up;Fostering;Functional disorder;Funding;Genetic;Human;Human Resources;imaging facilities;Imaging Techniques;indexing;Individual;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;Interview;Latinx population;Licensing;Magnetic Resonance Imaging;Maintenance;Measures;Medical Records;member;Methods;Minority;Minority Groups;Minority Health Research;Mission;Motor;Mutation;neurogenomics;neuroimaging;Neurologic;neuropsychiatric disorder;Neurosciences;Newspapers;next generation;novel;Outcome Measure;outreach;Parents;Participant;participant enrollment;Patient Recruitments;Phenotype;Play;Population;Population Heterogeneity;Prevention;programs;Psychologist;Records;recruit;Registries;remote assessment;remote grading;Research;Research Personnel;Research Project Grants;Resources;Role;Running;Sampling;Science;Scientist;searchable database;Sensory;Services;skills;Spectrum Analysis;Syndrome;teacher;Telephone;Testing;tool;Underrepresented Minority;underserved minority;virtual;Work

PROJECT_TITLE: HUMAN CLINICAL PHENOTYPING CORE


NIH_SPENDING_CATS: Antimicrobial Resistance;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Hematology;Infectious Diseases;Sepsis

ORG_CITY: RICHARDSON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: Public Relevance Statement The research proposed here uses state-of-the-art techniques to characterize the membrane lipids of the mitis group streptococci. These bacteria colonize and infect humans, causing a range of life-threatening infections. This research is significant for public heath because we will gain a better understanding of the structure and biosynthesis of the membrane lipids of these organisms, and how the lipids impact interactions of these bacteria with the host and with antimicrobials during colonization and infection.

PI_NAMEs: GUAN, ZIQIANG ;PALMER, KELLI LEA (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acyltransferase;Anabolism;anti-microbial peptide;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteremia;Bacteria;Biochemical;biological adaptation to stress;Cardiolipins;cell envelope;Charge;Child;Childhood;Choline;clinically significant;combat;community acquired pneumonia;coping;Culture Media;cytokine;Daptomycin;Detection;Development;Elderly;Electrostatics;Excision;Genes;Genetic;Glycerol;Gram-Positive Bacteria;Growth;Head;Heart Valves;host-microbe interactions;Housekeeping;Human;human pathogen;Immune response;Immunologic Stimulation;Individual;Infection;Infective endocarditis;inorganic phosphate;Knowledge;Lecithin;Life;lipidome;lipidomics;Lipids;lipoteichoic acid;liquid chromatography mass spectrometry;Lysophosphatidylcholines;Membrane;Membrane Biology;Membrane Lipids;Meningitis;mortality;mutant;novel;novel therapeutics;opportunistic pathogen;Organism;pathogen;pathogenic bacteria;Pathway interactions;Phosphatidylglycerols;Phospholipids;Phosphorylcholine;Phylogenetic Analysis;Physiological;Play;Polymers;Property;Proteome;Public Health;Research;research study;Resistance;response;Role;Sepsis;Serum;Signal Pathway;Signal Transduction;Streptococcus;Streptococcus mitis;Streptococcus oralis;Streptococcus pneumoniae;Stress;Structure;Surface Properties;Techniques;Time;Virulence

PROJECT_TITLE: Adaptive alterations of lipids in mitis group streptococci

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Nanotechnology;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: WASHINGTON

ORG_NAME: HOWARD UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative: Triple-negative breast cancer (TNBC) accounts for approximately 15% of invasive breast cancers; it is associated with aggressive tumor biology, poor prognosis, resistance, visceral metastases and earlier disease recurrence and is more common in younger women than in older women and in African-American and Hispanic women. To overcome the issues of toxicity, resistance and poor efficacy, we plan to develop multifunctional targeted polymeric nanoparticles which will prove more effective with less toxicity than the current standard of care therapies. A combination regimen using carboplatin and paclitaxel in the core of the nanoparticles and highly selective anti-EGFR targeted agent (cetuximab) tagged on the surface of the nanoparticles coupled with the power of nanotechnology will obviate suffering from toxicity, improve efficacy and overcome resistance.

PI_NAMEs: AKALA, EMMANUEL O (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: ABCB1 gene;Abraxane;Acceleration;Adjuvant;African American;Antibodies;antibody conjugate;biodegradable polymer;Biodistribution;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Breast Cancer Treatment;Bypass;cancer cell;Carboplatin;Cells;Cetuximab;chemotherapeutic agent;chemotherapy;Circulation;Clinic;Clinical Research;Combination Drug Therapy;Confocal Microscopy;Coupled;crosslink;Cytotoxic agent;cytotoxicity;Data Reporting;Development;Disease;Dose;Drug Combinations;Drug Delivery Systems;drug efficacy;Drug Efflux;Drug Kinetics;drug release kinetics;Dyes;efficacy evaluation;efficacy study;Epidermal Growth Factor Receptor;ERBB2 gene;Ethnic Population;Event;fabrication;FDA approved;Female;Fluorescent Dyes;Goals;Grant;Hispanic Women;Immunotherapy;Implant;improved;In complete remission;In Vitro;in vivo;interest;Label;Link;Literature;Liver;Malignant Breast Neoplasm;MDA MB 231;Mediating;Medical;Molecular;molecular targeted therapies;Monoclonal Antibodies;Morphology;Multi-Drug Resistance;Mus;nanoparticle;nanopolymer;Nanotechnology;nanotechnology platform;Neoadjuvant Therapy;Neoplasm Metastasis;Nude Mice;Numbness;older women;Outcome;overexpression;Paclitaxel;Pain;Particle Size;Pathologic;Patient-Focused Outcomes;Patients;Peripheral Nervous System Diseases;Persons;Pharmaceutical Preparations;Phase;Platinum;poly(lactide);Polymers;prevent;Prior Chemotherapy;Prognosis;programmed cell death ligand 1;Proteins;racial population;receptor;Recurrent disease;Regimen;Relapse;Resistance;response;Rhodamine 123;Site;SN-38;standard of care;Structure;subcutaneous;Surface;systemic toxicity;targeted agent;targeted delivery;targeted treatment;taxane;Therapeutic;Therapeutic Effect;Time;Toxic effect;triple-negative invasive breast carcinoma;tumor;Tumor Biology;Vertebral column;Visceral metastasis;Woman;Work;Xenograft Model;young woman;zeta potential

PROJECT_TITLE: Multifunctional Nanotechnology Platform for Triple Negative  Breast Cancer Treatment


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: MORROW, BERNICE E (contact)

PROJECT_TERMS: Address;Advisory Committees;Animal Model;Animals;Applications Grants;Architecture;Area;ATAC-seq;autism spectrum disorder;Award;Behavior Disorders;Bioinformatics;Biological;Biological Assay;Biomedical Research;brain malformation;Cancer Center;Cell Line;Cells;Chromatin;college;Complement;Complex;Computer Analysis;computerized data processing;Consultations;cost;cost effective;Data;Data Analyses;design;Diagnosis;Disability research;Disease;DNA;DNA analysis;DNA Modification Process;DNA Sequence;Ensure;epigenome;epigenomics;Evaluation;exome;exome sequencing;experience;experimental study;Familiarity;Feasibility Studies;flexibility;Foundations;functional genomics;Funding;Future;Gene Expression;Genes;Genetic;genome sequencing;genome-wide;genomic data;Genomics;Genotype;Goals;Grant;High Performance Computing;Human;Human Genetics;Human Resources;human subject;improved;Individual;induced pluripotent stem cell;innovation;innovative technologies;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;Investigation;large datasets;Measures;member;Methylation;Modeling;nerve stem cell;neurogenomics;Neurosciences;new technology;next generation sequencing;Nucleic Acid Regulatory Sequences;operation;Patients;Pharmaceutical Preparations;Pilot Projects;Population Genetics;Postdoctoral Fellow;Process;programs;Quality Control;Research;Research Design;Research Personnel;RNA;RNA Sequences;Role;secondary analysis;Services;single cell technology;single-cell RNA sequencing;skills;Solid;Structure;student training;Technology;Time;Tissues;Training;transcriptomics;Variant;voucher;whole genome

PROJECT_TITLE: NEUROGENOMICS CORE


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Lung;Women's Health Research

PHR: Breast cancer-related death primarily results from metastatic growth of disseminated cells. The goal of this project is to identify gene regulation programs that are critical for metastatic outgrowth of breast cancer cells and amenable to pharmacological inhibition to reduce metastatic burden in breast cancer patients.

PI_NAMEs: ROY, PARTHA  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Actins;Adopted;Behavior;Blood Vessels;bone;Brain;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;breast cancer progression;breast cancer survival;cancer cell;Cancer Etiology;cancer seeding;Cells;Cessation of life;Clinical;Collaborations;Competence;conditioning;connective tissue growth factor;Cytoskeleton;Data;Dependence;Developmental Biology;driving force;Extracellular Matrix;Extravasation;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Goals;Grant;Growth;Human;Impairment;improved;In Vitro;in vivo;Intervention;intravital imaging;Joints;Life;Link;Liver;Liver neoplasms;Lung;lung colonization;Lung Neoplasms;Malignant Breast Neoplasm;Malignant Neoplasms;Metastatic Neoplasm to the Bone;Micrometastasis;Modeling;mortality;mouse model;myocardin;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Organ;Organoids;Osteoclasts;Pathway interactions;Patients;pharmacologic;Phenotype;prevent;programs;Publications;Recording of previous events;Regulation;Research Personnel;Role;Sampling;Serum Response Factor;Site;small molecule;Stromal Cells;Study models;Testing;Time;Tissues;Transcription Coactivator;transcription factor;Transcriptional Regulation;tumor;tumor microenvironment;tumor progression;United States;United States National Institutes of Health;Up-Regulation;Women's mortality;Zebrafish

PROJECT_TITLE: Transcriptional Regulation of Dormancy and Emergence in Breast Cancer

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Foodborne Illness;Neurodegenerative;Social Determinants of Health

ORG_CITY: Auburn

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Project Narrative This proposal will focus on the identification of the biomarkers associated with various diseases and the development and validation of innovative high-resolution ion mobility devices which will be used for rapid diagnosis of foodborne and Alzheimer’s diseases which significantly impact the lives of millions of people. Our studies will enable high throughput analyses that are affordable and so easy-to-operate that can be performed by less-skilled users, such as nurses and their assistants. 1

PI_NAMEs: HAMID, AHMED MOHAMED (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: advanced analytics;Alzheimer's Disease;Antibiotic Resistance;Biological Markers;biomarker identification;Clinical;clinical care;Communities;Complement;Complex;conformer;Detection;Development;Devices;Diagnosis;diagnostic biomarker;Diagnostic Equipment;Diagnostic tests;Disease;foodborne;high throughput analysis;Hospitalization;innovation;interest;ion mobility;ionization;Ions;Isomerism;Lead;Methods;mobility aid;Molecular Structure;new technology;novel strategies;Nurses;Patient Care;Persons;Play;point-of-care diagnostics;portability;Preparation;rapid diagnosis;Recovery;Research;Resolution;Resource-limited setting;Role;Sampling;skills;Structure;targeted biomarker;Technology;Travel;Tube;usability;Validation;Variant

PROJECT_TITLE: Development of a Portable Ion Mobility Spectrometer For Efficient Diagnosis of Various Diseases