NIH_SPENDING_CATS: Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Acceleration;Advisory Committees;Articulation;Awareness;base;Behavioral Sciences;Biometry;Collaborations;college;Communication;Communities;Consultations;cost efficient;Country;Creativeness;Development;Diabetes Mellitus;diabetes risk;Disadvantaged;Doctor of Philosophy;Education;Ensure;Ethics;Ethnic Origin;Evaluation;Evolution;expectation;Faculty;flexibility;Funding;Funding Opportunities;Goals;Grant;Growth;Health;health equity;Health equity research;Health system;improved;Infrastructure;innovation;Institution;interest;Investments;Latino;Leadership;Life Cycle Stages;Maintenance;marginalized population;Medicine;member;Mentors;Methodology;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;New York;next generation;Obesity;Outcome;Performance;population health;Procedures;Process;Productivity;Program Evaluation;programs;Quality Control;racial minority;Reporting;Research;Research Design;Research Personnel;Research Proposals;Resources;Services;success;System;Technology;Translational Research;translational scientist;Translations;United States National Institutes of Health;Vision;web site;Work

PROJECT_TITLE: New York Regional Center for Diabetes Translation Research


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSICS

ORG_FIPS: US

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative The growing large-scale data of protein sequences, structures, and functions provide tremendous opportunities for life science, synthetic biology, precision medicine, and other areas. This project will develop integrative computational frameworks to advance our understanding of many topics centered around protein biology, including protein function characterization, structural and functional genomics, disease biology, and protein design. Successful completion of this project will result in new analytic tools and algorithms for a wide range of biomedical applications to help improve human health, such as drug discovery, vaccine development, and personalized diagnosis and treatment.

PI_NAMEs: LUO, YUNAN  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 3-Dimensional;Acceleration;Algorithms;Amino Acid Sequence;Amino Acids;analytical tool;Area;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence method;artificial intelligence model;Biological;Biological Sciences;Biology;Biomedical Engineering;Biotechnology;computational platform;computer framework;Computer software;Computing Methodologies;Data;data resource;Data Set;deep learning;deep learning algorithm;design;Directed Molecular Evolution;Disease;drug discovery;functional genomics;generative models;genome-wide;Goals;Health;Heterogeneity;high dimensionality;Human;human disease;improved;Knowledge;large scale data;Learning;machine learning method;Measurement;Mechanics;Modeling;next generation sequencing;Noise;novel;Ontology;personalized diagnostics;personalized medicine;precision medicine;Property;Protein Analysis;Protein Engineering;protein function;protein structure;protein structure prediction;Proteins;Research;Shapes;statistical learning;structural genomics;Structure;Structure-Activity Relationship;synthetic biology;Systems Integration;three dimensional structure;Uncertainty;vaccine development;Variant

PROJECT_TITLE: Integrative deep learning algorithms for understanding protein sequence-structure-function relationships: representation, prediction, and discovery


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Prostate Cancer;Social Determinants of Health;Urologic Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The goals of this proposal are to use population methods to recruit a diverse cohort of men with incident prostate cancer, perform combined evaluation of rare variant germline DNA repair genes (e.g. BRCA2) and a novel multi- ancestry polygenic risk score, to develop a clinical-grade paired tumor-germline assay and determine the biological significance of high PRSm and specific PRSm variants using tumor molecular profiles. We will also conduct a tailored prostate cancer screening clinical trial including at-risk first-degree relatives of men recruited through population methods and determine patterns of interest, enrollment and adherence to prostate cancer screening. Overall, we seek to investigate the synergy of germline genetic information with relevance to a diverse population with the goal of improving risk prediction and tailored PC screening for men across multi-ancestry populations.

PI_NAMEs: CHENG, HEATHER  (contact)

PROJECT_TERMS: Address;Adherence;African ancestry;Age;Biological;Biological Assay;BRCA2 gene;Cancer Biology;cancer diagnosis;Cancer Etiology;cancer genetics;Cancer Patient;cascade genetic testing;Cessation of life;Characteristics;Clinical;Clinical Data;clinical implementation;Clinical Management;clinical practice;clinical translation;Clinical Trials;cohort;Data;Death Rate;Disease;Disease Progression;DNA Repair Gene;Early Diagnosis;Early Intervention;Enrollment;Equity;Evaluation;Familial prostate cancer;Family;Family history of;First Degree Relative;Gene Mutation;Genetic;genetic information;genetic risk factor;genetic testing;genetic variant;Germ Lines;Germ-Line Mutation;Goals;Health behavior;health care availability;health care disparity;health disparity;high risk;high risk men;human old age (65+);improved;Incidence;Individual;Inherited;interest;Intervention;Life;male;Malignant neoplasm of prostate;Medical History;men;Metastatic Prostate Cancer;Methods;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;novel;Pacific Northwest;Patients;Pattern;polygenic risk score;Population;population based;Population Heterogeneity;Prognosis;Proprotein Convertase 2;prospective;prostate cancer progression;prostate cancer risk;rare variant;recruit;Relative Risks;Reporting;research clinical testing;Risk;Risk Factors;risk prediction;Sampling;Screening for Prostate Cancer;Socioeconomic Status;synergism;translational impact;tumor;Tumor Biology;Variant

PROJECT_TITLE: Project 1: Molecular Predictors of Prostate Cancer Progression and Mortality


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Hypertension

ORG_CITY: MAPUTO

ORG_COUNTRY: MOZAMBIQUE

ORG_FIPS: MZ

ORG_NAME: EDUARDO MONDLANE UNIVERSITY

PHR: Project Narrative This application will develop a dissemination and implementation model for the evidence-based Systems Analysis and Improvement Approach (SAIA) for the delivery of hypertension care for PLHIV that is delivered by district MOH supervisors (rather than research nurses), to serve as a foundation for national scaling in Mozambique. .

PI_NAMEs: MOCUMBI, ANA OLGA (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: acceptability and feasibility;Accountability;Address;Adherence;Adopted;Adoption;Adult;Affect;Africa South of the Sahara;Anti-Hypertensive Agents;antiretroviral therapy;Area;Awareness;Biological Models;Blood Pressure;Cardiovascular Diseases;care systems;Caring;Cessation of life;Chronic Care;Cities;Clinical;Cluster randomized trial;Communities;Complex;Consolidated Framework for Implementation Research;cost;Country;design;Diagnosis;Dissemination and Implementation;effective intervention;Effectiveness;effectiveness trial;Elements;Engineering;evidence base;evidence based guidelines;Failure;flexibility;Foundations;Frontline worker;Goals;Health;Health care facility;HIV;Hypertension;hypertension control;hypertension treatment;implementation process;implementation strategy;improved;Individual;Intervention;intervention effect;Link;low and middle-income countries;Maintenance;Modality;Modeling;Modification;Motivation;Mozambique;novel;Nurses;Nursing Research;organizational readiness;Outcome;Output;Patient-Focused Outcomes;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;Population;population health;Prevalence;Primary Care;Procedures;Process Measure;programs;Province;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Reporting;Research;Research Support;scale up;screening;Services;Standardization;Subgroup;success;System;system-level barriers;systematic review;Systems Analysis;Testing;tool;Treatment Effectiveness;uptake;Viral Load result;working group

PROJECT_TITLE: Scaling Out and Scaling Up the Systems Analysis and Improvement Approach to Optimize the Hypertension Diagnosis andCare Cascade for HIV-infected Individuals (SCALE SAIA HTN)


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: Chicago

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: OVERALL – PROJECT NARRATIVE The presence of major cancer health inequities in Chicago is well-documented. The Chicago Cancer Health Equity Collaborative (ChicagoCHEC), a comprehensive cancer research partnership between the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, the University of Illinois at Chicago, and Northeastern Illinois University, builds upon its productive first U54 award to continue strengthening collaborative infrastructure and implementing innovative cancer research, education, and outreach programs aimed at eliminating Chicago’s deeply-engrained cancer disparities.

PI_NAMEs: CIECIERSKI, CHRISTINA ;FEINGLASS, JOSEPH M;FILUS, LIDIA ;FITZGIBBON, MARIAN L. (contact);JIMBO, MASAHITO ;SIMON, MELISSA A.

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TERMS: Acceleration;Advanced Malignant Neoplasm;African American;anti-cancer research;Applications Grants;Award;cancer health disparity;Cancer health equity;Cancer Research Infrastructure;Cancer Research Project;career;Chicago;Circadian Rhythms;Cities;Clinical;Collaborations;Communities;community engagement;Community Outreach;community partners;Comprehensive Cancer Center;Decision Making;Dedications;disability;DNA Double Strand Break;Double Strand Break Repair;early-career faculty;Education;Education and Outreach;education research;empowerment;Evaluation;experience;Extramural Activities;Faculty;forging;Fortification;Funding;Funding Mechanisms;Generations;Goals;Grant;gut microbiome;Health Disparities Research;health disparity populations;health inequalities;Hematopoietic Stem Cell Transplantation;high risk;Hispanic-serving Institution;Illinois;improved;Infrastructure;innovation;Institution;Lead;Leadership;Long-Term Effects;lung cancer screening;Malignant Neoplasms;men;Mentors;mHealth self-management;Midwestern United States;Minority;minority student;Mission;next generation;oral microbiome;outreach;outreach program;Peer Review;Pilot Projects;Positioning Attribute;Prevention;Productivity;programs;Publications;rapid growth;Records;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Science;Scientist;social;Students;Survivors;survivorship;tool;Training;Translational Research;Transplant Recipients;Underrepresented Populations;Underrepresented Students;underserved community;Underserved Population;Universities;Variant

PROJECT_TITLE: 3/3: The Chicago Cancer HealthEquity Collaborative (ChicagoCHEC)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Prevention;Telehealth

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PI_NAMEs: GONZALEZ, JEFFREY S (contact)

PROJECT_TERMS: Address;Behavior;Behavioral Sciences;Biological;Biological Markers;biopsychosocial;Blood Glucose;Clinical;clinical care;Clinical Management;Collaborations;college;Communities;community based participatory research;community setting;Comparative Effectiveness Research;Consult;Consultations;COVID-19 pandemic;data integration;data streams;design;Diabetes Mellitus;diabetes risk;diabetes self-management;Diet;Dietary intake;Dissemination and Implementation;dissemination research;Effectiveness;effectiveness trial;Environment;Evaluation;Evaluation Methodology;evidence base;Evidence based practice;Evolution;experience;Faculty;Focus Groups;Foundations;Funding;graduate school;handheld mobile device;Health;Health behavior;Health behavior change;health care settings;health disparity;health equity;Health system;Health Technology;implementation research;Individual;innovation;Institution;Intervention;intervention effect;Intervention Studies;Intervention Trial;Knowledge;Life Style;Link;Measurement;Measures;medical schools;Medicine;Methodology;Methods;mHealth;Mission;Mobile Health Application;monitoring device;National Institute of Diabetes and Digestive and Kidney Diseases;New York;novel;Nutritional Science;Outcome;Outcome Measure;Participant;Patient-Focused Outcomes;Pharmaceutical Preparations;Physical activity;Program Effectiveness;Property;psychologic;Psychology;Quality Control;Reach, Effectiveness, Adoption, Implementation, and Maintenance;remote intervention;Research;Research Methodology;Research Personnel;Resources;Services;smartphone application;social influence;stakeholder perspectives;Targeted Research;Technology;Telemedicine;theories;Time;translational engagement;Translational Research;translational scientist;translational study;Translations;Ultrasonography;Universities;World Health


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Genetics

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Given the central importance of exosomal RNAs in dictating cellular behavior, there is a need and demand for real-time exosomal RNA imaging methods to determine how cells use exosomes and their cargoes to communicate and modulate their environment. The overall goal of this proposal is to develop probes, which will allow non-destructive tracking, barcoding, and imaging of exosomal RNAs. This will enable researchers to track exosomal RNAs through organisms, cells, and their ultimate destinations within subcellular compartments.

PI_NAMEs: NGUYEN, JULIANE  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: aptamer;Area;Bar Codes;Base Sequence;Biodistribution;Biogenesis;Biological Process;Cancer Biology;cancer cell;cell behavior;cell type;Cells;Code;Collection;Communication;design;Destinations;Discipline;Disease;Distant;Dyes;Effectiveness;Embryo;Environment;Epigenetic Process;Event;exosome;extracellular vesicles;Fluorescent Dyes;fluorophore;Gene Expression;Generations;Genetic;Genetic Transcription;Goals;Health;Human;Image;imaging modality;imaging probe;Immunology;in vivo;in vivo imaging system;Incubated;intercellular communication;kidney cell;Label;Lipids;Macrophage;Maps;MDA MB 231;Membrane;Membrane Lipids;Mesenchymal Stem Cells;Methods;Modeling;Morphogenesis;Movement;Multimodal Imaging;multimodality;Mus;Nature;Neurobiology;new technology;novel;novel marker;Organ;Organism;Phenotype;Physiological;Play;Process;Proteins;Publishing;Reagent;Research;Research Personnel;RNA;Role;single cell analysis;Sorting;Suspensions;Technology;Time;Tissues;tool;trafficking;Travel;tumor;Tumor-Derived;Untranslated RNA;uptake;Vesicle;Work

PROJECT_TITLE: Developing genetically encodable probes for multimodal tracking of exosomal RNA cargo

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: AMHERST

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: RELEVANCE (See instructions): Understanding genetic bases of biological function can alleviate ou r ability to understand and treat human disease. However, variable tandem repeats in the human genome have been difficult to characterize for functional and biomedical relevance. This research will leverage recently available long-read sequencing datasets to develop mathematical methods to investigate tandemly repeated sequences in the human genome, thus providing potentially transformative insights into genetic basis of human disease.

PI_NAMEs: MASUDA, NAOKI  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Affect;Algorithms;Animals;base;Belief;Biochemical;Biological;Biological Process;Biological Sciences;Code;Communities;Computing Methodologies;Conserved Sequence;Copy Number Polymorphism;cost;Data;Data Set;Databases;Detection;detection method;disease phenotype;DNA;dosage;Elements;Evolution;Explosion;Gene Expression;Genes;Genetic;Genetic Variation;Genome;genomic data;Goals;Grant;Graph;Grouping;heuristics;Human;human disease;Human Genome;Immunity;improved;insight;Instruction;Investigation;Ions;Label;Laplacian;Length;Link;mammalian genome;mathematical methods;Mathematics;Measurement;Measures;Metabolism;Methods;Minisatellite Repeats;Modeling;Molecular;Molecular Biology;Molecular Genetics;monolayer;National Institute of General Medical Sciences;network models;Noise;novel;paralogous gene;Pathway Analysis;Peat;Performance;Phenotype;Plants;Population;preservation;pressure;Probability;Protein Glycosylation;Proteome;Qi;Reporting;Research;Resolution;Resort;response;Running;Signal Transduction;Structure;success;Sum;Tandem Repeat Sequences;Technology;Testing;Text;tool;trait;Variant;Work

PROJECT_TITLE: DMS/NIGMS 1: Multilayer network approach to tandem repeat variation in genomes


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Astroviruses remain understudied despite their prevalence in nature, ability to cause disease in humans, and potential for zoonotic spread. Currently, we have a poor understanding of basic viral polyprotein production, interactions with host proteins, and manipulation of cellular organelles required for infection. Thus, the goal of the proposed projects is to take a multi-disciplinary approach to advance our knowledge of astrovirus molecular virology and cell biology of infection.

PI_NAMEs: LENNEMANN, NICHOLAS J (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Animals;Astrovirus;Biology;Birds;Cells;Cellular biology;Complementary DNA;CRISPR screen;design;Disease;Encephalitis;Enterovirus;Flavivirus;Foundations;Gastroenteritis;Goals;Human;Human Biology;Image;Infection;innovation;Integration Host Factors;interdisciplinary approach;Intracellular Membranes;Investigation;Knowledge;Libraries;Membrane;Molecular Virology;Nature;Organelles;Peptide Hydrolases;Polyproteins;Population;Prevalence;Production;protein expression;Proteins;Regulation;Reporter;Research;RNA Viruses;Serine Protease;signal peptidase;Site;Source;Structure;tool;Viral;Viral Nonstructural Proteins;Viral Proteins;Virus;Virus Diseases;virus host interaction;virus infection mechanism;Visualization;Work;Zoonoses

PROJECT_TITLE: Mechanisms of astrovirus infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NeuroTech Harbor (NTH) led by Johns Hopkins and Howard Universities will gather innovators, expert mentors, and resource providers to accelerate the development of highly promising solutions to improve neurological health for all. To address the lack of women and under-represented minority innovators, it will create the nation's first incubator ecosystem with an Equitech philosophy - the belief that diversity of teams, leadership, and perspectives is a force multiplier to fuel innovation producing solutions accessible to all communities.

PI_NAMEs: ETIENNE-CUMMINGS, RALPH ;MANAYE, KEBRETEN F;NWULIA, EVARISTUS A;SARMA, SRIDEVI V. (contact);THAKOR, NITISH VYOMESH;YAZDI, YOUSEPH

PROGRAM_OFFICER_NAME: WOLFSON, MICHAEL

PROJECT_TITLE: NeuroTech Harbor: Our nation's first equitech ecosystem for neuromedical technologies


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE The proposed work will evaluate combinations of systemic therapies, approved in metastatic PC, earlier in men with localized PC enrolled in GUNS to understand mechanisms of action and resistance, as well as the heterogeneity of clinical response. Insights into therapy-induced cellular plasticity will help guide biomarker development and expose new vulnerabilities to guide future combination strategies. These studies will define the ideal context for epigenetic targeting to reverse plasticity and increase vulnerability to standard care therapies.

PI_NAMEs: GLEAVE, MARTIN EDWIN (contact)

PROJECT_TERMS: abiraterone;Ablation;Acute;Address;Aftercare;Androgen Receptor;Androgens;ASCL1 gene;Back;Biological Markers;biomarker development;cancer subtypes;cancer therapy;Castration;Cell Lineage;Cells;Clinical;clinical heterogeneity;Clinical Management;Combined Modality Therapy;comparative;Development;DNA;DNA Sequence Alteration;Enrollment;enzalutamide;Epigenetic Process;epigenome;Epithelium;Evolution;EZH2 gene;Future;Genetic;Genetic Transcription;Genomic Segment;Genomics;Goals;high risk;improved;In complete remission;inhibitor;inhibitor therapy;insight;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Metastatic Prostate Cancer;Molecular;Molecular Analysis;multi-arm trial;multiple omics;Names;Neoadjuvant Study;Neoadjuvant Therapy;neoplastic cell;neuroendocrine phenotype;Neurons;Neurosecretory Systems;novel;novel therapeutic intervention;Pacific Northwest;Pathologic;Pathway interactions;patient derived xenograft model;Patient Selection;Patients;Pharmacodynamics;pharmacologic;Phenotype;Population;Population Dynamics;Pre-Clinical Model;Predisposition;Process;Prognosis;programs;prostate cancer cell;prostate cancer progression;Prostatectomy;Proto-Oncogene Proteins c-akt;Protocols documentation;PTEN gene;rational design;RB1 gene;Receptor Signaling;Regimen;Residual Neoplasm;Resistance;resistance mechanism;response;RNA;Shapes;Stains;standard care;standard of care;stem cells;Systemic Therapy;targeted treatment;Testing;Therapeutic;therapy development;therapy resistant;Tissues;TP53 gene;trial design;Triplet Multiple Birth;tumor;Up-Regulation;Work

PROJECT_TITLE: Project 2: Understanding and Targeting the Lineage plasticity in the Genomic Umbrella Neoadjuvant Study (GUNS)


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: TAMPA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: NARRATIVE The use of flavored electronic nicotine delivery systems (ENDS) is proliferating in the teen and young adult populations. It is not currently clear if inhaled flavorings in ENDS harm the heart. We will investigate whether flavorings in ENDS are toxic to the heart, and if inhalation exposure to such products adversely influence cardiac health.

PI_NAMEs: NOUJAIM, SAMI FOUAD (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Action Potentials;Adverse effects;aerosolized;Affect;age group;Aldehydes;Animal Model;Antioxidants;Apoptosis;Arrhythmia;base;Blood;C57BL/6 Mouse;Calcium;Cardiac;Cardiac health;Cardiac Myocytes;Cardiotoxicity;catalase;Cell Culture Techniques;Cell Line;Cells;Characteristics;Chemicals;cigarette smoking;Data;design;Electrocardiogram;Electrodes;electronic liquid;Electronic Nicotine Delivery Systems;Electronics;Electrophysiology (science);experimental study;Exposure to;extracellular;Fibrosis;Flavoring;Genes;Heart;heart rate variability;heart rhythm;High School Student;Human;human induced pluripotent stem cells;In Vitro;in vivo;induced pluripotent stem cell derived cardiomyocytes;Inhalation;Inhalation Exposure;insight;manufacture;Maps;Mass Spectrum Analysis;Measures;Mediating;Mitochondria;Monitor;Mus;Muscle Cells;Nicotine;Optics;overexpression;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Oxygen Consumption;Population;Proliferating;Public Health;reconstitution;Role;Smoke;Supplementation;System;Teenagers;Telemetry;Testing;Tobacco;tobacco advertising;tobacco products;Toxic effect;Transgenic Mice;Translating;vaping;vapor;Ventricular;young adult

PROJECT_TITLE: Cardiac Toxicity of Flavorings in Electronic Nicotine Delivery Systems


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ISASI, CARMEN R. (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Age;age group;Attention;Behavior;Behavior Therapy;Behavioral;Biological;Biological Factors;Biological Markers;Biological Process;biopsychosocial;Child;cohort;Consultations;critical period;Data;design;Development;diabetes control;Diabetes Mellitus;Diabetes prevention;disorder risk;Disparity;efficacious intervention;Ensure;ethnic disparity;Ethnic Origin;experience;Funding;Future;Goals;Health;health disparity;health equity;health inequalities;implementation facilitation;improved;Individual;Infrastructure;Institution;instrument;Intervention;Investigation;late life;Life;Life Cycle Stages;life span;Low Income Population;Measures;Mediating;member;Mentorship;Methodology;Methods;middle age;mobile computing;Modeling;modifiable risk;multidisciplinary;New York;novel;Observational Study;older adult;Outcome;Pathway interactions;Pattern;Phase;Policies;Population;Population Heterogeneity;Positioning Attribute;prevent;Prevention;Primary Prevention;Process;programs;promote resilience;Race;racial disparity;Research;Research Design;Research Personnel;resilience factor;Resources;Risk Factors;Secondary Prevention;Services;Shapes;Skin;social factors;social health determinants;stressor;structural determinants;success;tertiary prevention;theories;Translational Research;Translations;United States National Institutes of Health;Work


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: MADISON

ORG_NAME: WM S. MIDDLETON MEMORIAL VETERANS HOSP

ORG_STATE: WI

PHR: My overall research program has made significant and impactful contributions to understanding chronic multi- symptom illnesses, including Gulf War illness (GWI). GWI is characterized by a heterogenous symptom complex including chronic pain, fatigue and cognitive difficulties and affects approximately 250,000 Veterans of the first Gulf War. Through a systematic approach, I and my collaborators have demonstrated that GWI is characterized by deficits among multiple physiological systems that are related to their symptom experience and can be impacted by exercise. As a result, my current VA-sponsored research focuses on identifying the causes of GWI by testing across physiological systems both pre- and post-exercise challenge. These studies aim to identify how symptoms are maintained, provide important information for potential therapies, and help determine for whom exercise is safe, and for whom it may be detrimental. These studies are directly relevant to the mission of VA – to serve and care for those who have sacrificed and served our country.

PI_NAMEs: COOK, DANE B. (contact)

PROJECT_TERMS: active lifestyle;Acute;Affect;Aging;Alzheimer's Disease;Autonomic nervous system;Award;Behavior;Behavioral;biological systems;Blood;blood flow measurement;blood oxygen level dependent;Blood Pressure;Brain;brain behavior;Brain imaging;Cardiopulmonary;cardiopulmonary system;career;Caring;Central Nervous System;Cerebrovascular Circulation;Chronic;Chronic Fatigue Syndrome;chronic musculoskeletal pain;chronic pain;clinical care;Cognition;Cognitive;cognitive function;cognitive task;Collaborations;Complex;cooking;cost;Country;Data;Diffusion Magnetic Resonance Imaging;disability payment;Discipline;Disease;efficacious treatment;Endocrine;Exercise;Exertion;experience;Fatigue;Fibromyalgia;Freedom;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Future;Gene Expression;Goals;Gulf War;Gulf War veteran;Health;Image;imaging modality;Immune;Immune system;Immunity;Immunologic Tests;improved;indexing;insight;instrument;interdisciplinary approach;International;Journals;Leadership;Lymphocyte;Malaise;Measurement;Measures;Medicine;Mentors;Metabolic;metabolomics;Methodology;Methods;military veteran;Mission;Modeling;Nervous System Physiology;neuroimaging;Neurology;Neurosciences;Nonpharmacologic Therapy;operation;Pain;Pain Measurement;Pain Research;Paper;Persian Gulf Syndrome;Physical activity;Physiological;Plasma;Productivity;programs;protective effect;Proteomics;psychobiology;Psychophysiology;Publications;Publishing;Qualifying;Quality of life;Regulation;Reporting;Research;response;Rest;Rheumatology;Sampling;Science;Scientist;Sensory;Services;Source;Sports;Sports Medicine;Statistical Methods;Stimulus;Stress;Structure;Students;Symptoms;System;Technology;Testing;tool;treatment trial;United States Department of Veterans Affairs;Veterans;Visit;white matter;Work

PROJECT_TITLE: CSRD Research Career Scientist Award Application


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE We have discovered a prostate-specific protein that is highly expressed in advanced prostate cancer, developed a chimeric antigen receptor T cell therapy product to target this protein, and discovered that androgen receptor blockade improves T cell function. Therefore, the goal of this proposal is to perform preclinical studies to reveal feasibility and toxicity of this therapy and then open a novel phase I clinical trial.

PI_NAMEs: LEE, JOHN KYUNG (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Transfer;advanced prostate cancer;Affect;androgen independent prostate cancer;Androgen Receptor;Androgens;Antigen Presentation;antigen-specific T cells;Antigens;Biological;Biological Markers;Biopsy;Cancer Etiology;cancer immunotherapy;Cancer Patient;Cancer Vaccines;CAR T cell therapy;Cell Physiology;Cells;Cessation of life;checkpoint inhibition;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Data;Clinical Research;clinical translation;Clinical Trials;Combined Modality Therapy;comparative;cytokine release syndrome;Cytotoxic T-Lymphocytes;Dendritic Cell Vaccine;density;Disease;DNA;effector T cell;enzalutamide;Evolution;exhaust;exhaustion;fighting;first-in-human;FOLH1 gene;Future;Genetic;Goals;Granzyme;Hematologic Neoplasms;Heterogeneity;Human;human study;Immune system;Immunologics;Immunotherapy;improved;Inflammation;Inflammatory;Infusion procedures;inhibitor;insight;Interferon Type II;Investigational Therapies;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Oncology;Membrane;Memory;men;Metastatic Prostate Cancer;Molecular Analysis;mortality;Mus;Normal tissue morphology;novel;novel therapeutic intervention;Pacific Northwest;palliative;Patients;pharmacologic;Phase;Phase I Clinical Trials;Phenotype;pre-clinical;preclinical efficacy;preclinical safety;preclinical study;prevent;Process;programs;Prostate;prostate cancer model;Prostatic Neoplasms;Proteins;Radioisotopes;radioligand;Receptor Inhibition;Receptor Signaling;Resistance;response;Role;Safety;sex;six transmembrane epithelial antigen of the prostate 1;Solid Neoplasm;Specificity;success;Surface Antigens;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy outcome;Time;Tissues;Toxic effect;Translating;treatment response;Treatment-related toxicity;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor Tissue;United States

PROJECT_TITLE: Project 3: Modulating Androgen Receptor Signaling to Enhance the Efficacy of CAR T Cell Therapy for Advanced Prostate Cancer


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The goal of the Center for Innovative NeuroTech Advancement (CINTA) is to rapidly transform emerging technologies into commercially viable, clinically focused solutions for disorders of the nervous system as a hub under the NIH Blueprint MedTech: Incubator Hubs program. CINTA will support the advancement of neurotechnology solutions by adapting and improving upon the proven model that CIMIT developed and implemented for RADx Tech to accelerate promising neurotechnologies that address critical areas of unmet needs in the diagnosis and treatment of nervous system disorders to human-grade prototypes. CINTA plans to find, fund, facilitate, and accelerate 15 projects per year through this program.

PI_NAMEs: BONATO, PAOLO ;SCHACHTER, STEVEN C. (contact)

PROJECT_TERMS: Acceleration;Address;Area;Clinical;Collaborations;commercialization;Committee Members;Communities;Companions;Complex;Development;Diagnosis;Emerging Technologies;Ensure;Environment;equity, diversity, and inclusion;Evaluation;experience;Funding;Goals;Health Technology;Healthcare;Human;improved;Incubators;Infrastructure;innovation;Institution;interest;International;Investments;Laboratories;Leadership;manufacture;Medical;Medicine;Modeling;multidisciplinary;Needs Assessment;Nervous System Disorder;neurological rehabilitation;neurotechnology;Outcome;outreach;Performance;Process;programs;prototype;RADx Tech;Research;Research Personnel;Resources;Risk;Science;sharing platform;success;technological innovation;Technology;tool development;Training;Translational Research;United States National Institutes of Health;virtual technology;web site

PROJECT_TITLE: Center for Innovative NeuroTech Advancement - CINTA


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Social Determinants of Health

PI_NAMEs: CHAMBERS, EARLE C (contact)

PROJECT_TERMS: Acceleration;access disparities;Address;analytical method;Attention;Basic Science;Behavioral Sciences;Big Data;Chronic Disease;Clinical;Clinical Medicine;Clinical Research;Clinical Services;Collaborations;Communities;community engaged research;community engagement;Community Health;Community Healthcare;community intervention;community organizations;community partners;Complement;Complex;Consultations;Data;data access;data infrastructure;data integration;Databases;design;diabetes control;diabetes management;Diabetes Mellitus;Diabetes prevention;Dissemination and Implementation;Educational workshop;Equity;Evaluation;Evaluation Methodology;evidence base;Faculty;Faculty Recruitment;Funding;Goals;Health;health care availability;health care settings;health equity;health equity promotion;health information technology;health organization;Health Services Research;Health system;implementation intervention;improved;Individual;Informatics;informatics infrastructure;information organization;Information Systems;innovation;Institution;interest;Intervention;Latino;Learning;member;Mental Health;Methodology;Methods;Modeling;models and simulation;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Natural experiment;New York;New York City;novel;Obesity;obesity prevention;Observational Study;Outcome;Pathway interactions;Patients;peer;Persons;Policies;Population;population health;Populations at Risk;Practice based research;prevent;Prevention;Preventive service;programs;Public Health;Quasi-experiment;Recommendation;Records;Reporting;Research;Research Design;Research Personnel;Resources;Risk;Science;Services;social;social health determinants;social structure;success;System;systems research;Target Populations;Technology;Translational Research;translational research program;translational scientist;Translations;United States National Institutes of Health;Universities;uptake;Work


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: BURLINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Narrative Entrepreneurship is a complex series of activities that are both dynamic and very context dependent, critical to the successful translational of biomedical research discoveries; yet, entrepreneurial skills training is all but absent from traditional biomedical educational curricula. The Institutional Development Award IDeA- Entrepreneurship (I-Trep) training program is designed to provide a suite of opportunities that will moved the careers of a diverse group of young scientists forward. Biomedical entrepreneurship can be a career choice but it is also key to the commercialization of innovative ideas derived from investments in medical research with the goal to improve patient's lives.

PI_NAMEs: IRVIN, CHARLES G;THORNTON, TINA MARIE (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Active Learning;Address;Adoption;Affinity;Applications Grants;Award;bench to bedside;Biomedical Research;Biotechnology;Businesses;career;Career Choice;Case Study;Clinical;Collaborations;commercialization;Communication;community building;Community Developments;Community of Practice;Complex;Data;design;Development;Development Plans;Diagnostic Equipment;Ecosystem;Education Gap;Educational Curriculum;Educational workshop;Eligibility Determination;Entrepreneurship;experience;Fostering;Funding;Goals;graduate student;Grant;Healthcare Market;improved;Individual;innovation;Institution;Intellectual Property;Internships;invention;Investments;Knowledge;Laboratories;Learning;Legal patent;Marketing;Matched Group;Medical;Medical Device;Medical Research;meetings;member;Mentors;National Institute of General Medical Sciences;online community;Participant;Patient Recruitments;Patients;peer;peer coaching;Phase;Postdoctoral Fellow;preclinical development;Privatization;programs;Puerto Rico;recruit;Resources;Scientist;Secure;Series;skill acquisition;skills;skills training;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Speed;success;Support Groups;supportive environment;Technology;Technology Transfer;Therapeutic;Training;Training and Education;training opportunity;Training Programs;Translating;Translations;virtual;Woman;Work;Writing

PROJECT_TITLE: IDeA Entrepreneurship Training and Community Development


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative: Relevance to Public Health  Adult stem cells are potential vehicles for future regenerative therapies and they can also be critical cells for the earliest steps of development of several cancers, yet very little is known about the dynamics, organization and regulation of these stem cells. We propose to continue our studies of adult stem cells in the model genetic organism, Drosophila, in order to uncover basic principles of stem cell organization and regulation that are directly relevant, and of critical significance, to our understanding of how to harness human stem cells in medicine and how to combat cancer. Specifically, these studies are revealing how a community of stem cells is maintained, how individual stem cell lineages may undergo pre-cancerous amplification and how conserved signaling pathways, commonly altered in cancer, regulate proliferation, differentiation and competition among stem cells.

PI_NAMEs: KALDERON, DANIEL D (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adult;adult stem cell;Affect;Anterior;Apoptosis;aspirate;Behavior;Biological Assay;Cadherins;cell behavior;cell community;Cell Count;Cell Cycle;Cell Differentiation process;Cell division;Cell Lineage;cell motility;Cell Physiology;Cell Therapy;cell type;Cells;combat;Communities;community organizations;Cyst;Dependence;Development;Developmental Biology;directed differentiation;Disparate;Drosophila genus;Environment;environmental change;Epithelium;Erinaceidae;Event;Exhibits;Exposure to;extracellular;Extracellular Matrix;Face;fasciclin;Future;Genetic;genetic analysis;genetic manipulation;Genetic Models;genetic variant;Germ Cells;Germ Lines;Heterogeneity;Human;human stem cells;Image;Individual;insight;Intestines;Investigation;Link;Location;Malignant Neoplasms;Measurement;Measures;Mediator;Medical;Medicine;Methods;Modeling;Morphology;Mutation;Organism;Ovary;Pathway interactions;Pattern;Phase;Phosphatidylinositols;Phosphotransferases;Population;Positioning Attribute;premalignant;Process;Production;Proliferating;Property;Public Health;Reagent;regenerative cell;regenerative therapy;Regulation;Reporter;resilience;Resolution;response;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;Specific qualifier value;stem cell differentiation;stem cell division;stem cell function;stem cell model;stem cell population;stem cell proliferation;stem cells;Supporting Cell;Surface;System;Testing;Time;Transcriptional Regulation;transcriptome sequencing;transmission process;Visualization;WNT Signaling Pathway

PROJECT_TITLE: Somatic stem cells in the Drosophila ovary

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE The importance and relevance of this project centers on developing a new standard of care involving a targeted therapy to induce and exploit DNA repair deficient prostate cancer, to reduce the morbidity and mortality attributable to advanced prostate cancer and motivate studies designed to use individualized approaches to prioritize therapeutics likely to have substantial benefit in specific patient populations.

PI_NAMEs: NELSON, PETER S (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;advanced prostate cancer;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;Antibody-drug conjugates;attributable mortality;Automobile Driving;Biological Markers;Cancer Biology;cell killing;Cell Surface Proteins;Cells;chemotherapy;Clinical;clinical development;clinically relevant;cofactor;Combined Modality Therapy;Cytotoxic agent;Defect;Disease Progression;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Disorder;Dose;Drug Combinations;Exposure to;Fatigue;Genes;Genetic Transcription;genotoxicity;Growth;improved;interest;Ionizing radiation;Ligands;Malignant neoplasm of prostate;Mediating;Metastatic Prostate Cancer;Modality;Morbidity - disease rate;Muscular Atrophy;Mutation;neoplastic cell;Nuclear;Organ;Pacific Northwest;patient population;Patients;personalized approach;Pharmaceutical Preparations;Phase II Clinical Trials;Platinum;Poison;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;precision oncology;Process;programs;Proteins;Psyche structure;Quality of life;Radiation therapy;receptor expression;Receptor Signaling;repaired;Repression;Research;Research Design;Resistance;resistance mechanism;response;side effect;Signal Transduction;standard of care;Stanolone;Structure;targeted treatment;Testing;Testosterone;Therapeutic;therapeutic development;therapeutic target;Topoisomerase;transcription factor;treatment response;treatment strategy;Vertebral column;Work

PROJECT_TITLE: Project 4: Clinical Development of Therapeutic Strategies Targeting Damage Repair


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;Adult;Affect;Ancillary Study;Applications Grants;Area;Award;Awareness;base;Behavioral Sciences;Biological;biopsychosocial;cardiovascular risk factor;career development;cohort;Collaborations;combat;Communities;community engaged research;community engagement;Consult;Consultations;culturally appropriate intervention;Data;Data Set;Databases;design;diabetes control;diabetes management;Diabetes Mellitus;Diabetes prevention;diabetes risk;Disparity;Dominican;eHealth;Electronic Mail;ethnic minority population;Evaluation;Faculty;follow-up;Fostering;Funding;Genetic;Health;health care service;Health system;Healthcare;Healthcare Systems;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;improved;Individual;innovation;insight;Interest Group;Intervention;Latino;Latino Population;Lead;Life Cycle Stages;Life Style;Managed Care;Medicine;meetings;member;Mentorship;Methodology;Mexican;Minority;Modeling;multidisciplinary;New York;Not Hispanic or Latino;novel;Obesity;offspring;Outcome;Participant;Pathway interactions;Persons;Phenotype;phenotypic data;Population;population health;pragmatic intervention;Prediabetes syndrome;Prevalence;Process;Program Development;Program Evaluation;Provider;psychosocial;Puerto Rican;Quality of life;racial minority population;Research;research data dissemination;Research Personnel;Research Support;Research Training;Resources;Sampling;Science;secondary analysis;social culture;social determinants;South American;special interest group;Structural Racism;Students;success;Technology;Training Activity;Translational Research;virtual;Visit;World Health;Youth

PROJECT_TITLE: New York Regional Center for Diabetes Translation Research


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE H3K27M-mutant diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain cancers with no curative therapies available. We have identified a novel DIPG dependency on CDK9, a positive regulator of processive transcriptional elongation. Our proposed characterization of the H3K27M-mediated aberrations in processive transcription will both define a novel framework for understanding DIPG oncogenesis and inform mechanistic understandings critical to the safe translation of CDK9 inhibitors into phase 1 trials for DIPG.

PI_NAMEs: DAHL, NATHAN A (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: antitumor effect;Apoptosis;Area;ATAC-seq;Attenuated;Biological;Biological Assay;Biological Models;Brain Stem Neoplasms;Cancer Model;career development;chemotherapy;Childhood Malignant Brain Tumor;ChIP-seq;Chromatin;Chromatin Structure;clinical effect;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Curative Surgery;curative treatments;Data;Dependence;Development;Development Plans;Diagnosis;Diffuse intrinsic pontine glioma;Disease;DNA Damage;DNA Polymerase II;DNA Repair;Educational workshop;effective therapy;Engineering;Enhancers;Fractionated radiotherapy;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;H3 K27M mutation;Histones;improved;In Vitro;in vivo;inhibitor;inhibitor therapy;Ionizing radiation;Link;Malignant Neoplasms;Maps;Mechanics;Mediating;meetings;Mentorship;Modeling;Molecular;mouse model;Mus;Mutation;novel;Oncogenic;oncohistone;Pathogenicity;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pediatric Neoplasm;phase I trial;Post-Translational Protein Processing;pre-clinical;Precision Run-On Sequencing;Radiation Induced DNA Damage;Radiation therapy;recruit;Recurrence;Research;response;RNA;Role;Senior Scientist;standard of care;synergism;Testing;Therapeutic;Time;Training;Transcription Elongation;Transcription Initiation;Transcriptional Regulation;translational scientist;Translations;tumorigenesis;Untranslated RNA;Work

PROJECT_TITLE: CDK9-mediated processive transcription in H3K27M+ diffuse intrinsic pontine glioma

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Cancer;Kidney Disease;Rare Diseases;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Dr. Brian Shuch directs the UCLA Kidney Cancer program, part of the Institute of Urologic Oncology’s multidisciplinary clinical and research program. He is an established leader in clinical and translational kidney cancer research including roles within the SWOG and NCI Renal Task Force. Having the R50 Award would provide dedicated support for 1) the significant research time allocated to the conduct of NCI trials, 2) the leadership commitments in SWOG and the Renal Task Force, 3) the pursuit of new clinical concepts including a recently prioritized protocol, and 4) to further engage UCLA investigators to become involved in NCI clinical research.

PI_NAMEs: SHUCH, BRIAN  (contact)

PROGRAM_OFFICER_NAME: TAWAB-AMIRI, ABDUL

PROJECT_TERMS: Advisory Committees;Advocate;anti-cancer research;Award;career development;Caring;Cementation;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Dedications;Fellowship;Financial Hardship;Financial Support;imprint;improved;Individual;Industry;Institution;Kidney;Lead;Leadership;meetings;Mentorship;multidisciplinary;next generation;Oncologist;Operating Rooms;overtreatment;Patients;peer;Play;pressure;programs;protocol development;Protocols documentation;Renal Carcinoma;Renal Mass;Research;Research Personnel;Review Committee;Role;Scientist;Southwest Oncology Group;Specialist;Surgeon;Time;Translational Research;translational scientist;Travel;trial planning;United States National Institutes of Health;urologic;Urologic Oncology;Work

PROJECT_TITLE: NCI Research Specialist/Clinician Scientist Award for Urologic Oncology Research


ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Understanding the risks mild traumatic brain injury (mTBI) poses for neurodegeneration is critically important for Veterans. This proposal examines the contribution of mTBI to neurodegeneration with the intent of detecting behavioral and biomarker evidence of neurodegeneration due AD and CTE. Our hypothesis is that, after correcting for age, it is possible to separate the hallmarks of brain trauma related to TBI itself, from deficits related to neurodegeneration. [We will examine recognition memory, separating recollection and familiarity as a model of the cognitive changes underlying potential neurodegeneration. In addition to these behavioral techniques, complimentary data regarding the underpinnings of these cognitive processes provided by event-related potentials (ERPs), MRI, and cerebrospinal fluid (CSF) will allow further separation of possible AD and CTE.]

PI_NAMEs: TURK, KATHERINE W (contact)

PROJECT_TERMS: Age;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Atrophic;Award;Behavioral;Biological Markers;Brain Injuries;career;career development;cerebral atrophy;Cerebrospinal Fluid;chemokine;chronic traumatic encephalopathy;Clinical;cognitive change;cognitive control;cognitive process;cohort;Collection;Data;Data Analytics;Dementia;Deposition;Disease;Education;Electrophysiology (science);Environmental Risk Factor;Event-Related Potentials;experience;Experimental Designs;Experimental Psychology;experimental study;Familiarity;Goals;hippocampal atrophy;Hippocampus;human old age (65+);Image;Imaging Techniques;Impairment;interest;Knowledge;Late Onset Alzheimer Disease;Life;Light;Magnetic Resonance Imaging;Measurement;Measures;medial temporal lobe;Memory;Memory Loss;memory recognition;Mentors;mild cognitive impairment;mild traumatic brain injury;military veteran;Modeling;Nerve Degeneration;neurofilament;older adult;Outcome;Outcome Measure;Pathologic;Patients;Populations at Risk;Process;quantitative imaging;Recording of previous events;recruit;Regression Analysis;Reporting;Research;research and development;Research Personnel;Risk;skills;Source;Sports;tau Proteins;tau-1;Techniques;Testing;Thick;Time;Training;Traumatic Brain Injury;Veterans;young adult

PROJECT_TITLE: Contributions of mild traumatic brain injury to neurodegeneration due to chronic traumatic encephalopathy and alzheimer's disease


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

PI_NAMEs: MORRISSEY, COLM M (contact)

PROJECT_TERMS: Autopsy;biobank;Biological;Biological Specimen Banks;Biopsy;Blood;Budgets;Cancer Research Project;career development;Clinic;Clinical;Clinical Data;Clinical Research;Clinical Trials;Collaborations;Collection;Confidentiality of Patient Information;cost;Data;Databases;design;Development;DNA;Ensure;experience;Foundations;Funding;Future;Grant;Histologic;Histology;improved;In Situ Hybridization;Individual;Industry;Information Dissemination;Infrastructure;Institution;Institutional Review Boards;Laboratories;Maintenance;Malignant neoplasm of prostate;Measures;Minority;minority patient;Operative Surgical Procedures;Pacific Northwest;Pathologic;Pathologist;Pathology;Patient Compliance;patient derived xenograft model;Patients;Phenotype;Pilot Projects;Plasma;Policies;preclinical study;Preparation;Process;Production;Program Development;Program Efficiency;programs;quality assurance;Quality Control;Radical Prostatectomy;Recording of previous events;relational database;Reproducibility;Reproduction spores;Research;Research Activity;Research Personnel;Resources;RNA;sample collection;Sampling;Serum;Services;Specimen;Stains;Standardization;System;Tissue Microarray;tissue preparation;Tissues;United States National Institutes of Health;Urine;urologic;user-friendly;Work;Xenograft procedure

PROJECT_TITLE: Core B: Biospecimen and Pathology


NIH_SPENDING_CATS: Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition

PI_NAMEs: WYLIE-ROSETT, JUDITH  (contact)

PROJECT_TERMS: Address;Advocate;Area;Award;Awareness;base;Cardiometabolic Disease;Circulation;Collaborations;Consultations;COVID-19;design;Diabetes Mellitus;Early identification;Electronic Mail;Equity;Evaluation;Feasibility Studies;Feedback;Fostering;Funding;Future;Generations;Goals;Grant;Guidelines;health disparity;improved;Individual;innovation;Institution;interest;Letters;Medicine;member;Mentors;Methods;Names;New York;novel strategies;Obesity;Pilot Projects;Procedures;programs;racial disparity;Reporting;Request for Applications;Research;Research Personnel;Resources;Services;Surveys;Translational Research;United States National Institutes of Health;Update;web site


PHR: PUBLIC HEALTH RELEVANCE        The number of Americans diagnosed with Alzheimer's disease (AD) is expected to triple by 2050. Compared to the general population, Veterans have a greater risk of AD, likely in part due to their increased incidence of traumatic brain injury, post-traumatic stress disorder, depression, and other vascular-related health issues. Based on available data, 423,000 new cases of AD are anticipated in Veterans by 2020, including 140,000 cases directly attributable to military service. Thus, the discovery of effective therapies to prevent or delay the onset of AD in Veterans is critical. The goal of our study is to evaluate the efficacy of a purified form of the omega-3 fatty acid eicosapentaenoic acid (EPA) called icosapent ethyl (IPE), on improving brain blood flow, spinal fluid markers of AD pathology, and cognitive performance in middle-aged, cognitively-healthy Veterans with increased risk of AD. If IPE delays the onset of AD by even 5 years, the incidence of AD would be reduced by 50% in this population and could have a profound effect on Veteran quality of life and healthcare costs.

PI_NAMEs: CARLSSON, CYNTHIA M (contact)

PROJECT_TERMS: Acceleration;Acids;Adult;Affect;Age;Alleles;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid beta-42;Amyloid beta-Protein;analytical method;Animals;Antioxidants;Apolipoprotein E;Area;arterial spin labeling;Attenuated;Biological Markers;Blood Vessels;Brain;Cerebrospinal Fluid;Cerebrovascular Circulation;Cerebrum;Clinical;Clinical Trials;Clinical Trials Cooperative Group;Cognition;Cognitive;cognitive change;cognitive function;cognitive performance;cohort;cooperative study;Core-Binding Factor;Data;design;Development;Diagnosis;Disease;Docosahexaenoic Acids;Dose;Double-Blind Method;effective therapy;efficacy evaluation;Eicosapentaenoic Acid;Endothelium;Exposure to;FDA approved;Feedback;Formulation;Functional disorder;Funding;Future;General Population;Goals;Health;Health Care Costs;high risk;Human;Hypertriglyceridemia;Impaired cognition;improved;Incidence;Inflammation;interest;LDL Cholesterol Lipoproteins;Learning;Letters;Lipids;Low-Density Lipoproteins;Magnetic Resonance Imaging;Maintenance;Measures;Memory;Mental Depression;Metabolism;middle age;mild cognitive impairment;military service;Neurobehavioral Manifestations;Neurofibrillary Tangles;neuroimaging;Neurons;neuroprotection;novel;Omega-3 Fatty Acids;Outcome;Participant;Pathogenesis;Pharmaceutical Preparations;Phase;Phosphorylation;Physiological;Placebo Control;Placebos;Population;Post-Traumatic Stress Disorders;pre-clinical;pre-clinical assessment;preclinical study;Prevalence;prevent;Prevention;Prevention strategy;Prevention trial;primary endpoint;Process;programs;public health relevance;Quality of life;Randomized;Recommendation;Recording of previous events;Registries;Research Design;Risk;Safety;secondary endpoint;Senile Plaques;Site;Symptoms;tau Proteins;tau-1;Traumatic Brain Injury;United States;United States Food and Drug Administration;United States National Institutes of Health;Vascular Diseases;vascular risk factor;Veterans;Wisconsin

PROJECT_TITLE: Impact of Icosapent Ethyl on Alzheimers Disease Biomarkers in Preclinical Adults

STUDY_SECTION: CLNA

STUDY_SECTION_NAME: Clinical Trials - A[CLNA]


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Project narrative (relevance) One of the greatest hurdles to prolonging survival in patients with malignant brain tumors is the inevitable tumor recurrence in the vicinity of the original location or the resection cavities despite multimodal treatment including surgery, radiotherapy, and chemotherapy. We aim to develop a camptothecin drug amphiphile (DA) nanofiber hydrogel platform technology as adjunct therapy for intraoperative treatment of malignant brain cancer that can eradicate infiltrated glioma cells by maintaining a therapeutic concentration within the brain while minimizing systemic drug exposure. This goal will be achieved by evaluating and optimizing our current hydrogel- forming DA technology with in vitro, ex vivo and in vivo brain tumor models well-established in our laboratory, and the results of our study will validate a new local treatment strategy to combat currently incurable brain cancers with significant survival benefits and good tolerance.

PI_NAMEs: CUI, HONGGANG  (contact);QUINONES-HINOJOSA, ALFREDO

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Address;amphiphilicity;Animal Experiments;Animal Model;Animals;Antineoplastic Agents;Area;Behavior;biomaterial compatibility;Blood capillaries;Body Fluids;Brain;Brain Neoplasms;Camptothecin;cancer cell;cancer type;Carmustine;Cells;Chemicals;Chemistry;chemotherapy;Clinical;clinical development;clinical translation;Clinical Trials;combat;Combined Modality Therapy;controlled release;critical period;cytotoxicity;design;Diagnosis;Diffuse;Diffusion;Disease;Distant;Drug Carriers;Drug Design;Drug Exposure;Drug Kinetics;drug release kinetics;drug release profile;effective therapy;Evaluation;Excision;Exhibits;experimental study;Feedback;Foundations;functional group;Gel;Gliadel Wafers;Glioblastoma;Glioma;Goals;Histologic;Human;human disease;Hydrogels;immunogenicity;Implant;implantation;improved;In Vitro;in vivo;Infiltration;Investigation;irinotecan;Laboratories;Location;Malignant - descriptor;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;Measures;millimeter;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;nanofiber;Neoplasms;Newly Diagnosed;novel;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Penetration;Pharmaceutical Preparations;Phase;Play;pre-clinical;Primary Brain Neoplasms;Property;Radiation therapy;rational design;Recurrence;Recurrent disease;Recurrent tumor;Reproducibility of Results;Research Activity;residence;Rodent;Rodent Model;Role;Safety;self assembly;Series;side effect;Site;Surface;Surgically-Created Resection Cavity;Survival Rate;System;Technology;technology platform;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;Topotecan;Toxic effect;Translating;translational potential;Translations;treatment strategy;tumor;Tumor Tissue;Viscosity;Work

PROJECT_TITLE: Self-Assembling Camptothecin Nanofiber Hydrogels as Adjunct Therapy for Intraoperative Treatment of Malignant Glioma

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Social Determinants of Health

PHR: PROJECT NARRATIVE Families and clinicians feel unprepared to make decisions about tracheostomy and home ventilation for children with medical complexity. We propose a multi-institutional implementation and evaluation of HomeVENT (Home Values & Experiences Navigation Track), a decision-support process for families and clinicians. HomeVENT includes a novel, web-based tool to help families deliberate how their home life context and values affects decisions for or against home ventilation and a novel tool to help clinical teams jointly deliberate about a child's treatment options in light of their family's home context and values.

PI_NAMEs: BOSS, RENEE  (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Address;Affect;Cardiac;Caring;Child;Child health care;Childhood;Chronic;Clinical;Collaborations;Complex;Conflict (Psychology);Counseling;Data;Decision Making;design;Development;Dialysis procedure;Eligibility Determination;end of life care;Enrollment;Enteral Feeding;Ethics;Ethnic Origin;Evaluation;expectation;experience;Face;Family;Family Process;family structure;Genetic;Geography;Goals;Growth;health equity;Health system;Home;Hospitalization;housing instability;improved;Income;Individual;Institution;Intervention;Life;Life Expectancy;Life Experience;Light;Lung;Medical;Medical Technology;mortality;multidisciplinary;novel;Outcome;Parents;Perception;premature;primary outcome;Process;Program Evaluation;Psyche structure;Quality of life;Race;Readiness;recruit;Recurrence;Regrets;Research;Resources;respiratory;Respiratory Insufficiency;Risk;Role;Rural;secondary outcome;shared decision making;Social isolation;Source;Spanish;Structure;Syndrome;Technology;tool;Tracheostomy procedure;treatment as usual;ventilation;web-based tool;Work

PROJECT_TITLE: HomeVENT (Home Values and Experiences Navigation Track)

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

PI_NAMEs: ETZIONI, RUTH D (contact)

PROJECT_TERMS: Address;anti-cancer research;Bioinformatics;bioinformatics tool;Biological;Biometry;British Columbia;Cancer Center;Cancer Research Project;Collaborations;Collection;Communication;Communities;Complex;Data;Data Analyses;Data Collection;Data Set;design;Detection;Development;Ensure;experience;Funding;Head;Health;Human Resources;Individual;innovation;interest;invention;Investigation;Leadership;Link;Malignant neoplasm of prostate;Measurement;Metastatic Prostate Cancer;Methodological Studies;Methods;Molecular;novel;Oregon;Outcome;Pacific Northwest;Play;prevent;Productivity;Program Research Project Grants;Publications;Publishing;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Role;Sample Size;Sampling Studies;Science;Services;Source;Specific qualifier value;Statistical Data Interpretation;Statistical Methods;Systematic Bias;Target Populations;Translational Research;translational research program;Uncertainty;Universities;Validation;Work

PROJECT_TITLE: Core C: Biostatistics and Bioinformatics


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity;Prevention

PROJECT_TERMS: Academy;Award;career;career development;Cities;Collaborations;Communication;COVID-19 pandemic;Creativeness;Dedications;diabetes control;Diabetes Mellitus;Diabetes prevention;diversity and inclusion;Educational Status;Educational workshop;faculty support;Funding;Goals;Grant;health equity;Institution;Internet;Latino;Leadership;lectures;Medicine;member;Mentors;Mentorship;Metabolic Diseases;Multimedia;New York;novel;Obesity;outreach;programs;Publications;Research;Research Methodology;Research Personnel;Resources;Role;Series;Services;social media;Talents;Training;Training and Education;Translational Research;United States National Institutes of Health;Universities;virtual;virtual education;virtual platform;Work


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: FITZGIBBON, MARIAN L. (contact);JIMBO, MASAHITO

PROJECT_TITLE: Administrative Core


PI_NAMEs: PETERSON, CARYN E.;PETERSON, CARYN E. (contact)

PROJECT_TERMS: Achievement;Advisory Committees;analytical tool;anti-cancer research;Award;Benchmarking;cancer health disparity;Cancer health equity;Cancer Research Project;career;career development;catalyst;Chicago;Clinical Sciences;Communication;community engaged approach;Consultations;Counseling;Data;Data Analyses;data tools;Decision Making;Development;early-career faculty;Educational workshop;Ensure;Evaluation;experience;Faculty;faculty mentor;Foundations;Funding;Funding Mechanisms;Goals;Grant;Health;health disparity;improved;Incubators;Infrastructure;innovation;Institution;Intervention Studies;Knowledge;Leadership;Logic;Malignant Neoplasms;mathematical model;member;Mentors;Mentorship;Mission;Modeling;Monitor;novel;Outcome;Performance;Pilot Projects;Process;process improvement;Program Development;programs;Progress Reports;Quasi-experiment;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Resources;Running;skills;Statistical Data Interpretation;Structure;Surveys;Time;Translational Research;Universities;Work

PROJECT_TITLE: Planning and Evaluation Core


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Prostate Cancer;Urologic Diseases

PI_NAMEs: LIN, DANIEL W. (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;Basic Science;Biometry;British Columbia;Cancer Center;cancer health disparity;cancer therapy;Clinical;Clinical Management;Clinical Sciences;Collaborations;design;Development;Disease Management;Early Diagnosis;Endowment;Etiology;Faculty;feasibility testing;Feedback;Foundations;Funding;General Hospitals;Goals;Government;Grant;Guidelines;Health;Health Promotion;improved;Infrastructure;innovation;Institution;interest;Investments;Malignant neoplasm of prostate;Manuscripts;meetings;member;Minority Groups;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Oregon;Outcome;Pacific Northwest;Patients;Phase;Pilot Projects;Population;Population Study;Prevention;Prevention strategy;Prognosis;Program Research Project Grants;programs;Prostate;Quality of life;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;research study;Resources;Science;Scientist;Site;Source;survivorship;Therapeutic;translational goal;Translational Research;Travel;treatment strategy;Underrepresented Minority;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: Developmental Research Program


NIH_SPENDING_CATS: Cancer;Pediatric;Social Determinants of Health

PI_NAMEs: GRIPPO, PAUL J (contact);KIM, SAGE J.

PROJECT_TERMS: Address;African American;anti-cancer research;Area;Attention;cancer health disparity;Cancer health equity;Cancer Science;career;career development;career preparation;Chicago;Cities;college;Communities;community college;community engagement;community partners;Comprehensive Cancer Center;curriculum development;design;Development;disability;Disparity;Diverse Workforce;diversity and equity;Dryness;Education;education research;Educational Activities;Educational Curriculum;Educational Status;Ensure;Ethnic Origin;Evaluation;experience;Faculty;Fortification;Fostering;Foundations;Funding;Gender;Goals;Grant;Health Disparities Research;health disparity;Healthcare;high school;Hispanic;Illinois;Immersion;improved;Influentials;Institution;interest;Internships;laboratory experience;Laboratory Research;life-long learning;Link;lower income families;Malignant Neoplasms;Medical Students;Medicine;member;Mentors;Minority;minority student;Not Hispanic or Latino;peer;Postdoctoral Fellow;Program Evaluation;programs;Race;Readiness;Recording of previous events;Research;research faculty;Research Personnel;Research Project Grants;Science;science education;Science, Technology, Engineering and Mathematics Education;skills;social culture;Social Network;Structure;Student recruitment;Students;success;summer program;summer research;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;university student;Work

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: NAYLOR, KEITH BRIAN;TUSSING-HUMPHREYS, LISA  (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Advanced Malignant Neoplasm;anti-cancer research;Area;Award;Awareness;cancer care;cancer education;cancer health disparity;Cancer health equity;cancer prevention;Cancer Survivor;Cancer Survivorship;cancer therapy;Chicago;Cities;citizen science;Clinical;Clinical Trials;Collaborations;Communities;community engaged approach;community engagement;Community Health;Community Networks;community organizations;Community Outreach;community partners;community partnership;community-centered;Comprehensive Cancer Center;Continuity of Patient Care;Death Rate;Development;disability;Disabled Persons;Disparity;Dissemination and Implementation;Early Diagnosis;Education;Education and Outreach;education research;Educational Activities;ethnic minority;Evaluation;Event;evidence base;Evidence based practice;experience;Faculty;forging;Fostering;Funding;gender minority community;Geographic Locations;Grant;Health;health disparity populations;Health Educators;health equity;Health equity research;Health Fairs;Human;Illinois;Immersion;improved;Incidence;Individual;Inequity;innovation;Institution;Interview;Lead;Leadership;Linguistics;literacy;Localized Malignant Neoplasm;Low income;Malignant Neoplasms;Maps;member;men of color;minority communities;mortality;Needs Assessment;Neighborhoods;neoplasm registry;outreach;Outreach Research;peer;peer coaching;Penetrance;Persons;Phase;Population;Positioning Attribute;Prevention;process evaluation;Productivity;programs;racial minority;Recommendation;Research;Research Personnel;Research Project Grants;Resources;response;screening;Secure;Services;Sexual and Gender Minorities;Students;Surveys;survivorship;symposium;tool;underserved community;Underserved Population;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Aging;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE: The proposed research is of great importance to public health because it will advance our understanding of extreme heat as an environmental trigger of acute myocardial infarction - a leading cause of death and morbidity - and the potential modifying roles of sex, socioeconomic status, pre-existing chronic conditions, medication use, and air pollution. Such knowledge will enable policymakers to refine recommendations to protect vulnerable populations from extreme heat and/or air pollution events and will enable clinicians to provide evidence-based advice to vulnerable patients about preventing acute myocardial infarction under conditions of extreme heat and air pollution.

PI_NAMEs: CHEN, KAI  (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Acute myocardial infarction;Address;Adult;Age;aged;Air;Air Pollutants;Air Pollution;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Blood Platelets;Calcium Channel;Calcium Channel Blockers;Cardiovascular system;Cause of Death;Cessation of life;Chronic;Climate;climate change;cohort;Coupled;Crossover Design;Data;Data Set;design;Diabetes Mellitus;disability;Disparity;Diuretics;Dyslipidemias;Environmental Exposure;Environmental Hazards;epidemiologic data;Epidemiology;Evaluation of Risk Factors;Event;evidence base;Exposure to;extreme heat;extreme temperature;fine particles;Gender;German population;Heat Waves;high risk;High temperature of physical object;Hospital Mortality;hospitalization rates;Hospitals;Humidity;Hypertension;indexing;Intake;Interview;Knowledge;Link;low socioeconomic status;Medical History;Medical Records;men;Mental Depression;Modeling;Modification;Morbidity - disease rate;mortality;Non-linear Models;observational cohort study;older adult;older patient;Outcome;Ozone;ozone exposure;Particulate;Patients;Persons;Pharmaceutical Preparations;Physiological;Policy Maker;Population;Poverty;prevent;Prevention strategy;Probability;prospective;Public Health;receptor;Recommendation;Recovery;Registries;Research;Resolution;Risk;Risk Estimate;Risk Factors;Role;sex;Smoking;socioeconomic disparity;Socioeconomic Status;socioeconomics;spatiotemporal;Subgroup;Temperature;Time;tropospheric ozone;Variant;Vulnerable Populations;Woman;Work;young adult;young man;young woman

PROJECT_TITLE: Extreme Heat and Acute Myocardial Infarction: Effect Modifications by Sex, Medical History, and Air Pollution

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Clinical Research;Mental Health

PI_NAMEs: SARMA, SRIDEVI V. (contact)


NIH_SPENDING_CATS: Clinical Research;Mental Health;Neurosciences;Social Determinants of Health

PI_NAMEs: NWULIA, EVARISTUS A (contact)

PROJECT_TERMS: Address;Advocacy;Aging;Area;arm;Awareness;Black race;Clinical;Color;commercialization;Communication;Communities;community building;Development;Diagnostic;diversity and inclusion;Ecosystem;Education;Educational workshop;Elements;Engineering;Ensure;Environment;Equilibrium;Evaluation;experience;Family;Feedback;Fostering;Goals;Governing Board;Grant;Heart;high reward;high risk;Historically Black Colleges and Universities;improved;Incubators;Industry;innovation;Latinx;Lead;Leadership;Learning;Marketing;member;Mental disorders;Mental Health;Minority-Serving Institution;Mission;Needs Assessment;Nervous System Disorder;Neurosciences;neurotechnology;outreach;Patients;Play;programs;prospective;Readiness;Research;Research Personnel;Resource-limited setting;response;Scientist;Services;Social Impacts;stakeholder perspectives;STEM student;success;Technology;Therapeutic;Training;Training and Education;Translations;Universities;Vision;Woman;Work;Writing

PROJECT_TITLE: Outreach


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PI_NAMEs: NELSON, PETER S (contact)

PROJECT_TERMS: anti-cancer research;Area;British Columbia;career;career development;Career Mobility;Clinical;Collaborations;Committee Members;Discipline;Education;experience;Exposure to;Faculty;faculty mentor;follow-up;Funding;General Hospitals;Goals;Grant;Guidelines;Health Sciences;Individual;Institution;interest;Malignant neoplasm of prostate;member;Mentors;Minority;Mission;Monitor;multidisciplinary;Oregon;organizational structure;Pacific Northwest;Patient advocacy;Population;Preparation;Procedures;Process;Productivity;programs;Prostate;Qualifying;recruit;Recruitment Activity;Research;Research Activity;research faculty;Research Personnel;Research Support;Resources;Scientist;Site;success;symposium;System;Talents;Time;Training;Underrepresented Minority;Universities;Washington;Woman;Work

PROJECT_TITLE: Career Enhancement Program


PI_NAMEs: YAZDI, YOUSEPH  (contact)

PROJECT_TERMS: Address;Authorization documentation;Clinical;Complex;Development;Ecosystem;Elements;Ensure;Equity;Evaluation;Feedback;Funding;Future;graduate student;Historically Black Colleges and Universities;Human Resources;improved;Industry;innovation;Learning;Life Cycle Stages;manufacture;Medicine;meetings;member;Methodology;Modeling;outreach;Peer Review;Preparation;Process;Published Comment;RADx;Recommendation;recruit;Resources;Specialist;success;System;Technology;Technology Assessment;Training;Triage;underserved community;United States National Institutes of Health;web platform;web portal;Work

PROJECT_TITLE: Evaluation Core


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Mental Health

PI_NAMEs: ETIENNE-CUMMINGS, RALPH  (contact)

PROJECT_TERMS: Acceleration;Address;Area;Clinical;Collaborations;commercialization;design;Development;Dreams;Ecosystem;Equity;Evaluation;Failure;first-in-human;Funding;Goals;Human;Industry Standard;Institutional Review Boards;Investments;Medical Device;Mentors;Mentorship;Monitor;Outcome;Participant;Patients;Population;programs;prototype;Recommendation;recruit;Research Project Grants;Resource Allocation;Resources;risk mitigation;success;Technology;Technology Assessment;timeline;tool;United States National Institutes of Health;Work

PROJECT_TITLE: Innovator Subprojects Core


PI_NAMEs: THAKOR, NITISH VYOMESH (contact)

PROJECT_TITLE: Resource Subawards Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Declines in both muscle and bone health with aging increase the risk of osteoporotic fractures, which are associated with high morbidity, mortality, and cost. Computed tomography (CT) scans have strong potential to better detect older adults at risk of fracture by assessing both muscle and bone, including bone strength – a strong predictor of fracture risk. By examining CT-derived measures of muscle and bone as well as muscle mass, muscle performance, and blood biomarkers in an aging population, this study will help us better understand the relationship between muscle and bone, and may identify new clinical screening markers and intervention targets to prevent, diagnose, and treat muscle and bone decline, and ultimately prevent fractures in older adults.

PI_NAMEs: WEAVER, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: 3-Dimensional;Adult;Age;age acceleration;age related;Aging;aging population;aging related;American;Aminobutyric Acids;Anatomy;Ancillary Study;Area;biobank;Biochemical;Biological Assay;Biological Markers;Biology;Biomedical Engineering;Biometry;Blood;Blood specimen;Body mass index;bone;Bone Density;bone health;bone loss;bone mass;bone strength;circulating biomarkers;Clinical;clinical care;clinical practice;clinically relevant;cohort;cost;cost effective;Creatine;Cyclophosphamide;Data;density;Detection;Diagnosis;Dual-Energy X-Ray Absorptiometry;Economic Burden;Elements;Extensor;Fatty acid glycerol esters;follow-up;Fracture;fracture risk;Gait speed;gamma-Aminobutyric Acid;Heterogeneity;high dimensionality;high risk;hip bone;Hip region structure;human old age (65+);improved;insight;Intervention;Investigation;Knowledge;Leg;longitudinal design;Longitudinal Studies;Measures;Mechanics;Mediating;Mediation;men;Mobility disability;Modeling;Morbidity - disease rate;Morphology;mortality;multidisciplinary;Muscle;muscle aging;muscle degeneration;muscle form;Muscular Atrophy;Musculoskeletal;novel;older adult;older men;older women;Open Fractures;Osteoporosis;osteoporosis with pathological fracture;Patients;Performance;performance tests;Phenotype;Population;Positioning Attribute;prevent;Prevention;primary outcome;Property;Prospective Studies;radiomics;remediation;Research;Research Personnel;Risk;Sampling;sarcopenia;Scanning;screening;Site;Skeletal Muscle;Testing;Texture;therapeutic target;Thick;Thigh structure;Time;Treatment Efficacy;uptake;Vertebral column;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Computed tomography muscle size and composition associations with hip and spine bone strength over 4 years: SOMMA-CT

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Bioengineering;Mental Health

PI_NAMEs: SCHACHTER, STEVEN C. (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Area;Benchmarking;career;Charge;Clinical;Committee Membership;Communities;Companions;Conflict of Interest;Data Security;Diagnosis;Elements;equity, diversity, and inclusion;experience;Feedback;Funding;Glean;Guidelines;Healthcare;Human;improved;Infrastructure;innovation;interest;Investments;Leadership;Life Experience;Modeling;Needs Assessment;neighborhood disadvantage;Nervous System Disorder;Neurology;neurotechnology;Online Systems;operation;outreach;Patient advocacy;patient oriented;Patients;Point of Care Technology;Policies;Primary Care;Process;programs;prototype;RADx Tech;Recommendation;Research;Resources;Role;Secure;Structure;Technology;Time;tool development;Translations;United States National Institutes of Health;Voice;Work

PROJECT_TITLE: Center for Innovative NeuroTech Advancement (CINTA) - Administrative Core


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Mental Health;Mental Illness;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Emotion regulation skill use is emerging as a transdiagnostic treatment mechanism and may have important implications for adolescent alcohol use disorder and co-occurring disorder treatment, yet research in this area is lacking. By leveraging ecological momentary assessment methods, the goal of this K99/R00 is to examine emotion regulation skill use as a treatment mechanism in an intensive outpatient program for youth with co- occurring disorders. Findings from this project could inform the refinement of existing interventions and the creation of new, more effective ones.

PI_NAMEs: JENZER, TIFFANY  (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: acceptability and feasibility;Address;Adolescence;Adolescent;adolescent alcohol treatment;adolescents with alcohol use disorders;Adult;aged;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol use disorder;Ambulatory Care;Anxiety;Area;associated symptom;Attention deficit hyperactivity disorder;Behavior;Communities;Comprehension;cost;Data;Development;Diagnosis;Diagnostic;Dialectical behavior therapy;Disease;dual diagnosis;Ecological momentary assessment;effective intervention;emotion dysregulation;emotion regulation;Emotional;Enrollment;executive function;Exhibits;experience;feasibility testing;Feedback;Goals;Grant;Growth;improved;Intervention;Learning Skill;Mental Depression;Mental disorders;Mentors;Methods;National Institute on Alcohol Abuse and Alcoholism;Nature;outpatient programs;Participant;participant enrollment;Patient Self-Report;Phase;Pilot Projects;Population;Population Intervention;Procedures;Process;prospective;Protocols documentation;Psychiatric Diagnosis;Psychopathology;randomized, clinical trials;Reporting;Research;Research Personnel;Resources;Role;Sampling;satisfaction;Scientist;skill acquisition;skills;skills training;Strategic Planning;Symptoms;Testing;Training;Treatment outcome;treatment program;underage drinking;Work;Youth

PROJECT_TITLE: Examination of emotion regulation strategy use in an outpatient treatment program for adolescents with co-occurring disorders

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Mental Health

PROJECT_TERMS: Address;Advocate;Area;Caregivers;Collaborations;commercialization;Communication;Communities;Development;Diagnosis;Education;Electronic Mail;equity, diversity, and inclusion;Evaluation;experience;Face;Focus Groups;Funding;Incubators;Industry;innovation;Interdisciplinary Study;interest;Leadership;meetings;Mentors;Methods;Needs Assessment;Nervous System Disorder;news;Outcome;outreach;Patients;Performance;Press Releases;Process;Professional Organizations;programs;Publications;Research;research data dissemination;Risk;Services;social media;Specific qualifier value;success;Technology;tool;Training;Translational Research;United States National Institutes of Health;Voice;web site

PROJECT_TITLE: Center for Innovative NeuroTech Advancement (CINTA) - Outreach Core


PROJECT_TERMS: Acceleration;Address;Area;Budgets;Companions;Competence;Diagnosis;Ensure;equity, diversity, and inclusion;Evaluation;experience;Family member;Funding;Goals;Grant Review Process;Health;Human;improved;Industry;Infrastructure;innovation;interest;Investments;Leadership;Mentors;Methods;Modeling;Monitor;Nervous System Disorder;neurotechnology;Patients;Peer Review;Persons;Probability;Process;programs;prototype;RADx;RADx Tech;Recommendation;Resources;response;Risk;screening;success;Technology;timeline;Triage;underserved community;United States National Institutes of Health;Work

PROJECT_TITLE: Center for Innovative NeuroTech Advancement (CINTA) - Evaluation Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative Poor diabetes self-management including lower medication adherence, negative social determinants of health factors such as food insecurity, and health misperceptions such as negative beliefs about diabetes and medicines, place Black and Hispanic adults at disproportionately greater risk for severe diabetes-related harms and death compared to other racial/ethnic groups in the US. Despite the availability of effective interventions for diabetes management that address poor medication adherence and optimize medication therapy, and address social determinants of health barriers and health misperceptions, there is a gap in understanding whether combining these interventions will maximize their effectiveness and cost-effectiveness for Black and Hispanic adults with uncontrolled diabetes, contributing to improvements in glycemic levels and medication adherence when added to usual care. This innovative factorial randomized mixed method trial evaluates the benefits of pharmacist-delivered medication therapy management and/or a community health worker addressing social determinants of health barriers to diabetes medication adherence, and health misperceptions, as well as qualitatively exploring intervention components/combinations’ acceptability based on participant experiences, which supports identification of an optimized intervention package with profound public health implications for Black and Hispanic adults with diabetes.

PI_NAMEs: CHUI, MICHELLE ANNE (contact)

PROGRAM_OFFICER_NAME: RAJAPAKSE, NISHADI

PROJECT_TERMS: Address;Adherence;adherence rate;Adult;Affect;Behavioral Mechanisms;Belief;Black Populations;Black race;Cessation of life;chronic care model;Community Health Aides;community intervention;community partners;Complement;Complications of Diabetes Mellitus;contextual factors;cost effective;cost effective intervention;cost effective treatment;cost effectiveness;Cost Effectiveness Analysis;design;diabetes management;Diabetes Mellitus;diabetes risk;diabetes self-management;Disparity;disparity reduction;Education;effective intervention;Effectiveness;empowerment;Ethnic Population;experience;experimental study;food insecurity;glycemic control;Glycosylated hemoglobin A;Goals;Health;health disparity;Hispanic;Hispanic Populations;improved;innovation;Intervention;intervention participants;Interview;Lived experience;Long-Term Effects;Maintenance;Mediation;Mediator;medication compliance;Medication Management;medication nonadherence;Medicine;Methods;Modeling;Morbidity - disease rate;mortality;multiphase optimization strategy;Not Hispanic or Latino;optimal treatments;Outcome;Participant;Patient Self-Report;Patients;peer;peer support;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;primary outcome;psychosocial;Public Health;Qualitative Methods;racial population;Randomized;Risk;secondary outcome;Self Management;social culture;social health determinants;Social support;Stress;Testing;theories;Translations;treatment as usual;treatment optimization;Work

PROJECT_TITLE: A Multiphase Optimization Strategy to Enhance Diabetes Management Interventions for Black and Hispanic Patients with Uncontrolled Diabetes

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Depression;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Serious Mental Illness;Suicide

ORG_CITY: EAST LANSING

ORG_DEPT: PSYCHIATRY

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: PROJECT NARRATIVE Individuals of African descent tend to have greater disease burden but are underrepresented in genomics research. This study seeks to better characterize their genetic structure of the major histocompatibility complex (MHC) region; hence it addresses an important knowledge gap that has immediate and measurable health consequences for a population group that represents ~13% of the U.S. population. Its implication in suicide genomics is relevant to the public health because suicide accounts for more than 45,000 deaths each year in U.S. New resource in this project will also enable fine-mapping studies for other neuropsychiatric diseases.

PI_NAMEs: GUI, HONGSHENG  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: adaptive immune response;Address;African;African American population;African ancestry;All of Us Research Program;Alleles;Amino Acids;Antigenic Variation;Antigens;Area;arm;Autoantigens;Autoimmune Diseases;Behavior;biobank;Bipolar Disorder;Black race;burden of illness;causal variant;Cessation of life;Chromosomes;Chronic;clinical care;Code;comorbidity;COVID-19 impact;Data;data mining;Data Set;Death Rate;Diagnostic and Statistical Manual of Mental Disorders;Diploidy;disability;Disease;Disease Pathway;Disease susceptibility;European;Evaluation;Feeling suicidal;Genes;Genetic;genetic architecture;Genetic Code;Genetic Predisposition to Disease;Genetic Structures;Genetic study;genome resource;genome sequencing;genome wide association study;genomic data;Genomic Segment;Genomics;Genotype;Goals;Graft Rejection;Grain;Haplotypes;Health;HLA Antigens;Host Defense;Human;Human Genetics;Hybrids;Immune response;Immune System Diseases;Immunologics;improved;Individual;Inflammatory;inflammatory marker;Inflammatory Response;innovation;International;Knowledge;Link;Linkage Disequilibrium;Longitudinal cohort;Major Depressive Disorder;Major Histocompatibility Complex;Maps;Measurable;Mediating;Medical;Mental disorders;Mental Health;Minority Groups;neuroinflammation;neuropsychiatric disorder;Not Hispanic or Latino;novel sequencing technology;Participant;Pattern;Phase;phenome;phenomics;Phenotype;phenotypic data;physical conditioning;Population;Population Group;Population Heterogeneity;post-transplant;precision medicine;Process;Proteins;Public Health;Reduce health disparities;Reporting;Research;Research Personnel;Resolution;Resources;Risk Factors;risk variant;Role;Sampling;Schizophrenia;severe mental illness;Shotgun Sequencing;Single Nucleotide Polymorphism;social determinants;suicidal;suicidal behavior;Suicide;Suicide attempt;Technology;Transplantation;United States;Variant;Virus Diseases;whole genome

PROJECT_TITLE: Assembly and re-alignment of HLA genomic region and its implication for fine-mapping suicidality in African descent population


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Alcohol and cannabis are the most misused psychoactive substances in the United States, and their misuse among African American young adults has the potential to be especially problematic. The proposed research examines how direct and vicarious discrimination experiences may lead to alcohol and cannabis use among African American young adults. The proposed research is also designed to identify possible targets for culturally responsive prevention and treatment efforts to help reduce drug use.

PI_NAMEs: LUI, P. PRISCILLA  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: acute stress;Address;Adult;African American;African American population;aged;Alcohol consumption;alcohol craving;alcohol misuse;alcohol risk;alcohol use disorder;Alcohols;Anger;Biomedical Research;Buffers;Cannabis;cannabis craving;Communities;coping;Correlation Studies;craving;design;Diagnosis;diagnostic criteria;Discrimination;drinking;Drug usage;Environment;ethnoracial disparity;Etiology;experience;experimental group;experimental study;Exposure to;Female;Funding;Goals;Health Services;Hearing;Hour;Individual;innovation;Intervention;Knowledge;Link;Literature;male;marijuana use;marijuana use disorder;Measures;Mediator;Methods;Motivation;National Institute of Drug Abuse;novel;Outcome;Participant;Pathway interactions;perceived discrimination;Pharmaceutical Preparations;polysubstance use;Prevention;Privatization;Procedures;protective factors;Public Health;Race;racial discrimination;Racial Equity;racism;Randomized;recruit;Reporting;Research;risk mitigation;Role;rumination;Science;simulation;social;social determinants;Stimulus;Stress;Stress and Coping;Structure;substance misuse;substance use;Testing;Thinking;Time;United States;United States National Institutes of Health;university student;Victimization;virtual reality;virtual reality simulation;young adult

PROJECT_TITLE: Effects of Direct and Vicarious Discrimination on Alcohol and Cannabis Cravings: Virtual Reality Experiment

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]