ADMINISTERING_IC: LM

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL LIBRARY OF MEDICINE

ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: Project Narrative Region 3 of the Network of the National Library of Medicine (NNLM), hosted by Gibson D. Lewis Library at the University of North Texas Health Science Center (UNTHSC) in Fort Worth, Texas, will serve the states of Arkansas, Kansas, Louisiana, Missouri, Nebraska, Oklahoma, and Texas. The Regional Medical Library (RML) supports the mission of the NNLM to provide health professionals, the public health workforce, educators, and the public with equal access to biomedical and health information resources and data. The RML will offer diverse trainings, funding mechanisms, and regional and national programming, with a focus on collaboration and continuous assessment to develop a highly-trained workforce and serve as trusted ambassadors between the National Library of Medicine and the communities they serve.

PI_NAMEs: BURGARD, DANIEL ERIC (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Access to Information;Arkansas;biomedical resource;Collaborations;Communication;Communities;community engagement;community organizations;Community Outreach;Consultations;County;cultural competence;Data;Dedications;Diverse Workforce;Ensure;Environment;Evaluation;experience;Fostering;Foundations;Funding;Funding Mechanisms;Funding Opportunities;Goals;Health;health equity;health literacy;Health Personnel;Health Professional;Health Science Library;Health Sciences;Home;Hospitals;improved;Incubators;Information Resources;innovation;insight;Institution;Joints;Kansas;Learning;Libraries;Library Services;literacy;Louisiana;Medical Libraries;medical schools;member;Mission;Missouri;Nebraska;Oklahoma;Osteopathic Medicine;outreach;Performance;programs;Public Health;Research;Research Personnel;Resources;Rest;Schools;Services;skills;social health determinants;socioeconomics;Texas;Thinness;tool;Training;trauma centers;Trust;Underrepresented Populations;Underserved Population;United States National Library of Medicine;Universities;usability

PROJECT_TITLE: Regional Medical Library for Region 3 of the Network of the National Library of Medicine (AR, KS, LA, MO, NE, OK, TX) and National Public Health Coordination Office


ARRA_FUNDED: N

FUNDING_MECHANISM: OTHERS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PROJECT_TERMS: Area;Back;Businesses;Collaborations;Communication;Communities;Data;Data Pooling;Disasters;Ensure;Environment;Evaluation;Event;experience;extreme storms;feeding;Fostering;Funding;Goals;hazard;Health;health equity;health literacy;Health Science Library;Health Sciences;Hurricane;improved;Information Resources;innovation;Libraries;Marketing;Measurable;Medical Libraries;member;Mission;operation;Outcome;outreach;Pattern;Policies;Process;programs;Public Health;Readiness;response;Rest;Services;severe weather;skills;socioeconomics;Texas;Time;Tornadoes;Training;United States National Library of Medicine;Universities;Vision

PROJECT_TITLE: Regional Medical Library for Region 3 of the Network of the National Library of Medicine: Admin


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Congenital Structural Anomalies;Genetics;Heart Disease;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Autosomal Dominant Polycystic Kidney Disease (ADPKD) manifests with progressive renal dysfunction. However, cardiovascular diseases are the major cause of morbidity and mortality in  these patients. In this application, we propose to elucidate the molecular mechanism driving cardiac dysfunction in ADPKD patients.

PI_NAMEs: ALTAMIRANO, FRANCISCO  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Ablation;Acceleration;Action Potentials;Affect;Age;Alleles;Automobile Driving;Autosomal Dominant Polycystic Kidney;Biochemical;Ca(2+)-Transporting ATPase;Calcium;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cause of Death;Cells;Clinical;comorbidity;Complement;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;defined contribution;Dose;Economic Burden;Electrophysiology (science);Event;Exhibits;Functional disorder;Gene Mutation;Genes;healthcare burden;Heart;Heart Diseases;Heart failure;heart function;Hereditary Disease;Heterozygote;Histologic;Human;human induced pluripotent stem cells;Hypertension;Impairment;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell derived cardiomyocytes;insight;Intervention;Kidney;kidney cell;Kidney Diseases;kidney dysfunction;Kidney Failure;knock-down;Knock-in;Knockout Mice;Kv channel-interacting protein 2;Left;life span;Methods;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutation;Myocardial dysfunction;NG-Nitroarginine Methyl Ester;novel;overexpression;Pathway interactions;Patients;Persons;pharmacologic;phospholamban;polycystic kidney disease 1 protein;Potassium;Potassium Channel;Predisposition;Process;Proteins;Quality of life;Regulation;renal epithelium;Reporting;Role;Sarcoplasmic Reticulum;sarcoplasmic reticulum calcium ATPase;Signal Transduction;small molecule;Techniques;Testing;Time;Ventricular;Ventricular Dysfunction

PROJECT_TITLE: Mechanisms driving cardiac dysfunction in Autosomal Dominant Polycystic Kidney Disease

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Perianal fistulizing complications of Crohn’s disease are common and morbid, which are routinely treated with prolonged and frequent antibiotic courses, despite lack of evidence for efficacy. This proposed multicenter study is relevant to improving the appropriate use of antibiotics by promoting antibiotic stewardship and decreasing healthcare related infections, because it focuses on treating and preventing perianal fistulas and abscess through developing multi-disciplinary comprehensive evidence-based treatment guidelines for the judicious use of antibiotics while improving care for children with Crohn’s disease. Thus, the proposed research is relevant to the part of AHRQ’s mission to produce evidence to make health care safer and higher quality.

PI_NAMEs: ADLER, JEREMY  (contact);GADEPALLI, SAMIR KUMAR

PROGRAM_OFFICER_NAME: LIN, LEYI

PROJECT_TITLE: Standardization of Evaluation to Treatment of pediatric perianal Crohn’s disease and improving Outcomes through Networking (SETON)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Address;Agriculture;Alaska Native;American Indians;Arkansas;Award;Awareness;barrier to care;biomedical resource;Black race;Collaborations;Communities;Community Health;community organizations;Competence;Continuing Education;Country;County;Dangerousness;Data;Data Science;Diabetes Mellitus;Disease;Ensure;Face;farm worker;Floods;forest;Funding;Future;Health;health care availability;health disparity;health equity;health literacy;Health Personnel;Health Science Library;Health Sciences;Hispanic;Home;improved;Incidence;Industry;Information Resources;interest;Joints;Kansas;Librarians;Libraries;Locales;Louisiana;marginalized community;Measurable;Measures;Medical Libraries;member;Mexico;Migrant;Minority;Mission;Mississippi;Missouri;Modality;Music;Native-Born;Natural Disasters;Nebraska;Occupations;Oklahoma;Outcome;outreach;Population;Poverty;programs;Public Health;Research Personnel;Rural Population;skills;socioeconomic disadvantage;Testing;Texas;Training;training data;Tribes;Trust;underserved community;United States;United States National Library of Medicine;Universities;Veins

PROJECT_TITLE: Regional Medical Library for Region 3 of the Network of the National Library of Medicine: Program


ADMINISTERING_IC: MH

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative The overarching objective of this project is to enable multimodal noninvasive stimulation and recording of human brain circuits with high anatomical and temporal precision. The project is to create a closed-loop brain interface that integrates simultaneous neural recording and high-fidelity MRI acquisition with steerable transcranial stimulation. The proposed brain interface is a new noninvasive tool for studying human brain circuits in vivo and for therapeutic interventions.

PI_NAMEs: LIU, CHUNLEI  (contact);LUSTIG, MICHAEL ;PETERCHEV, ANGEL V

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Acoustic Stimulation;Address;Algorithms;Anatomy;Auditory;auditory pathway;blood oxygen level dependent;Bluetooth;Brain;Brain imaging;Brain Mapping;Cephalic;Clinical;Computer software;Custom;Data;data communication;design;Development;Disease;Effectiveness;Electrodes;Electroencephalography;Electromagnetics;Electronics;energy efficiency;Evaluation;experience;Feedback;flexibility;flexible electronics;Foundations;Functional Magnetic Resonance Imaging;Funding;Head;Health;Human;Image;improved;in vivo;industry partner;invention;magnetic field;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Maps;Measures;Methods;miniaturize;Morphologic artifacts;multimodality;Nature;neural;neural circuit;neuroregulation;Neurosciences;Neurosciences Research;new technology;Noise;novel;operation;Pattern;Performance;Persons;Phase;Positioning Attribute;Printing;Research;Research Personnel;Resolution;response;Robot;robotic system;Robotics;Safety;Signal Transduction;sound;spatiotemporal;Speed;Synapses;System;Systems Integration;Techniques;Technology;temporal measurement;Therapeutic Intervention;Thinness;Time;tool;Transcranial magnetic stimulation;United States National Institutes of Health;wireless;Work

PROJECT_TITLE: Robotically-actuated, low-noise, concurrent TMS-EEG-fMRI system


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Antimicrobial Resistance;Hematology;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Sepsis

ORG_CITY: BATON ROUGE

ORG_DEPT: PATHOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: NARRATIVE Sepsis is the second leading cause of death in non-coronary intensive care units (ICUs) and is in the top ten causes of death in the U.S. Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) are common complications of sepsis Despite advances in treating sepsis, specific therapies are not available and clinical trials using the FDA-approved Xigris (recombinant form of human activated protein C) and Eritoran (a TLR4-MD2 antagonist) have not been successful. The goal of this project is to boost the innate immune system so that the host cells will function better to eradicate bacterial pathogens in organs due to sepsis-induced systemic infection in order to mitigate excessive tissue damage.

PI_NAMEs: JEYASEELAN, SAMITHAMBY  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Ablation;activated Protein C;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Adoptive Transfer;Affect;Alveolar Macrophages;antagonist;Antimicrobial Resistance;assault;Attenuated;Bacteremia;Bacteria;Bacterial Infections;Binding;Blocking Antibodies;Blood;Bone Marrow;CASP1 gene;Cause of Death;cecal ligation puncture;Cells;Clinical Trials;Complication;CXCL1 gene;cytokine;Data;drotrecogin alfa;Drug resistance;Emergency Situation;Epithelial Cells;Escherichia coli;Escherichia coli Infections;experimental study;Failure;FDA approved;Fostering;Functional disorder;Goals;Granulopoiesis;Hematopoietic;Host Defense;Host Defense Mechanism;Host resistance;Human;IL18 gene;Immune;Immune response;Immunity;improved;In Vitro;in vivo;Infection;Inflammasome;Injury;innate immune mechanisms;Innate Immune Response;Innate Immune System;Intensive Care Units;knock-down;Knockout Mice;Knowledge;Lung;Lung infections;Macrophage;Marrow;Mediating;Membrane;microbial signature;molecular modeling;mortality;Multi-Drug Resistance;Multiple Organ Failure;Mus;Myeloid Cells;Natural Immunity;neutrophil;Neutrophil Infiltration;new therapeutic target;novel therapeutic intervention;Organ;organ injury;overexpression;pathogenic bacteria;Peritoneal;Peritoneal Macrophages;Peritoneum;Predisposition;Proteins;Public Health;receptor;Recombinants;recruit;response;Role;Sepsis;septic;Septic Shock;Serum;Signal Transduction;Site;Small Interfering RNA;Spleen;Stromal Cells;Systemic infection;systemic inflammatory response;targeted treatment;Testing;Tissues;TLR4 gene;Toll-like receptors;treatment strategy;Up-Regulation;Work

PROJECT_TITLE: Host Immunity in Sepsis-Induced Systemic Infection


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because sixty percent of arteriovenous fistulas created in hemodialysis patients in the United States fail to mature for successful use on hemodialysis. Improving the understanding of the pathogenesis of arteriovenous fistula maturation failure will lead to development of new therapies to treat this important clinical problem, and will help reduce the use of hemodialysis catheters. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to developing fundamental knowledge to help reduce morbidity and mortality for patients on hemodialysis requiring a vascular access.

PI_NAMEs: LEE, TIMMY C (contact);SHIU, YAN-TING E.;SYMONS, JOHN DAVID

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Address;Anastomosis - action;Arteriovenous fistula;Atherosclerosis;Autophagocytosis;Autophagosome;biobank;Blood flow;Blood Vessels;Catheters;Chronic Kidney Failure;Clinical;clinically relevant;Coculture Techniques;Cultured Cells;Data;Development;Dialysis procedure;Diameter;effective therapy;End stage renal failure;Endothelial Cells;Endothelium;Etiology;exposed human population;Failure;Fistula;Functional disorder;Generations;Goals;Harvest;Hemodialysis;hemodynamics;Histologic;Homeostasis;Human;human disease;Hyperplasia;improved;In Vitro;in vivo;Innovative Therapy;Knockout Mice;Knowledge;Lysosomes;Mediating;Mission;Morbidity - disease rate;mortality;Mus;Nitric Oxide;NOS3 gene;novel;novel therapeutics;Organelles;Outcome;Pathogenesis;Pathologic;Pathology;Patients;Perfusion;Play;porcine model;preservation;prevent;Procedures;Process;Proteins;Public Health;Radiology Specialty;Repression;Research;Resources;response;Role;Serum;Signal Pathway;Smooth Muscle Myocytes;Stenosis;System;Testing;therapeutic target;tool;ultrasound;Umbilical vein;United States;United States National Institutes of Health;Vasodilation;Veins;Venous;Work

PROJECT_TITLE: Autophagy and Arteriovenous Fistula Maturation

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: HD

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The Post-Doctoral Training Program in Intellectual and Developmental Disabilities (IDD) Research provides interdisciplinary biobehavioral training focused on IDD and prepares trainees for a career of research in this area. IDD are a diverse group of conditions that affect 6.99% of U.S. children; the scientific workforce focused on IDD research is considerably smaller than the magnitude of this public health need, creating an urgency for training programs to develop new investigators in this field. The success of our training program is evidenced by the high rate of placement of “graduates" in faculty and research-intense positions, the success of former trainees in receiving research awards by NIH and other federal sources, the expansive volume of publications by our trainees in top-tier journals, and the longstanding fidelity of our trainees to IDD research.

PI_NAMEs: HARTLEY, SIGAN L (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Disability research;Intellectual functioning disability;post-doctoral training

PROJECT_TITLE: Post-Doctoral Training in Intellectual and Developmental Disabilities Research


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PORTLAND

ORG_DEPT: NEUROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative This project seeks to inform clinical trials by providing a new tool (i.e., practice effects on measures of daily functioning) for predicting cognitive progression in seniors with and without cognitive impairment. By completing this pragmatic project, we would be able to offer more efficient screening of potential participants for clinical trials, which would reduce participant burden and financial costs associated with these trials. Practice effects also have considerable clinical benefits for diagnosis and prognosis of cognitive disorders in late life.

PI_NAMEs: DUFF, KEVIN M (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Address;Adult;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid deposition;amyloid imaging;apolipoprotein E-4;Biological Markers;Brain Pathology;Clinic;Clinical;clinical trial participant;Clinical Trials;Cognition;Cognition Disorders;Cognitive;cognitive function;cognitive testing;daily functioning;Data;demented;Dementia;Diagnosis;Disease;Enrollment;experience;Exposure to;Financial cost;follow-up;functional decline;Future;Goals;Heterogeneity;Hippocampus;Impaired cognition;Impairment;improved;Individual;innovation;Intervention;late life;Link;Literature;Magnetic Resonance Imaging;Materials Testing;Measures;Memory;Methodology;mild cognitive impairment;Mission;Monitor;National Institute on Aging;normal aging;novel;older adult;Older Population;Outcome;Outcome Measure;Participant;Performance;performance based measurement;performance tests;Positron-Emission Tomography;predictive tools;Prognosis;Proxy;Research;Research Personnel;Resources;response;Risk;Sampling;Savings;screening;Screening procedure;Severity of illness;Target Populations;tau Proteins;Testing;Time;tool;treatment response;Work

PROJECT_TITLE: Practice effects of daily functioning across the Alzheimer's disease spectrum


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This new projects will explore the role of the Long Interspersed Nuclear Element-1 (LINE-1, or L1) in type I interferon-mediated SLE. We will continue to characterize autoantibodies against L1-encoded proteins, ask how early in the disease they appear, how L1 transcription is upregulated in SLE, which cells that express it, and if the L1 expressing cells also contain reverse-transcribed RNA and interferon beta. Finally, we will test inhibitors of L1 reverse transcriptase in these cells.

PI_NAMEs: MUSTELIN, TOMAS M (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Adjuvant;Autoantibodies;Autoantigens;Autoimmunity;Automobile Driving;B-Lymphocytes;Biological Markers;Biology;Blocking Antibodies;cancer cell;Cell Aging;Cell Death;cell type;Cells;Childhood;clinical development;Complement;Complex;Consumption;Crohn's disease;Data;density;Dependence;Development;Disease;DNA;ds-DNA;Elements;emtricitabine;Event;experimental study;FDA approved;Flare;Funding;Gender;gene induction;Genetic Transcription;Goals;granulocyte;HIV;Human;IFNAR1 gene;IgG autoantibodies;Immune;Immune system;immunogenic;inhibitor;Interferon Type I;Interferon-beta;Interferons;Journals;L1 Elements;Lupus;Measures;Mediating;Methods;Molecular;monocyte;Nephritis;neutralizing monoclonal antibodies;neutrophil;Nuclear;Paper;Pathogenesis;Pathway interactions;Patients;Phase;Phase II Clinical Trials;Phase III Clinical Trials;Play;Process;Production;protein complex;Protein Family;Proteins;Research;Retrotransposon;Reverse Transcription;RNA;RNA-Directed DNA Polymerase;Role;sensor;Serum;Signal Pathway;Signal Transduction;Stimulator of Interferon Genes;stress granule;Systemic Lupus Erythematosus;targeted treatment;Tenofovir;Testing;Transcript;transcriptome sequencing;type I interferon receptor;Virus;Virus Diseases;Work

PROJECT_TITLE: Role of the L1 retrotransposon in interferon-positive SLE

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Over 30,000 Americans die from hepatocellular (liver) carcinoma (HCC) every year and current treatments do not provide long-term benefit, highlighting the urgent need for new and effective therapies. We have discovered that a protein called EZH2 is required for the growth of HCC tumors, and found that inhibiting EZH2 not only blocks HCC tumor growth but also enhances the ability of the immune system to eradicate the tumor. The results of the experiments proposed in this application will establish the mechanism by which EZH2 functions as an HCC oncogene and evaluate EZH2 inhibitors, alone or in combination with other anti-cancer drugs, as novel HCC therapies.

PI_NAMEs: KELLIHER, MICHELLE ALICE (contact);WAJAPEYEE, NARENDRA

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Accounting;Agar;American;Antineoplastic Agents;bevacizumab;Carcinoma;Catalytic Domain;Cell model;cell motility;Cell Proliferation;Cell surface;Cells;Cessation of life;chemokine;Clinical;Clinical Treatment;Clinical Trials;clinically relevant;Combined Modality Therapy;Complex;Cultured Cells;CXCL10 gene;Development;Drug Targeting;DUSP6 protein;Ectopic Expression;effective therapy;Epigenetic Process;epigenetic silencing;Epithelioid Sarcomas;Experimental Models;experimental study;EZH2 gene;Follicular Lymphoma;Gene Silencing;Genes;Growth;hepatocellular carcinoma cell line;histone methyltransferase;Human;humanized monoclonal antibodies;humanized mouse;Immune system;inhibitor;knock-down;Ligands;Liver;liver cancer model;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;MAPK3 gene;Mediating;Mitogen-Activated Protein Kinases;Molecular;mouse model;Mus;Mutate;Natural Killer Cells;neoplastic cell;new therapeutic target;Non-Hodgkin's Lymphoma;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;overexpression;Pathway interactions;Patients;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Poly(ADP-ribose) Polymerase Inhibitor;Polycomb;Primary carcinoma of the liver cells;programmed cell death ligand 1;Proteins;Publishing;Regimen;Repression;Role;Sampling;small molecule;small molecule inhibitor;Solid Neoplasm;Testing;therapeutic target;Treatment Efficacy;tumor;tumor eradication;tumor growth;Tumor Immunity;Tumor Promotion;Tumor Suppressor Genes;Tumor Suppressor Proteins;United States;Vascular Endothelial Growth Factors;Xenograft procedure

PROJECT_TITLE: Role of EZH2 as a Driver and Therapeutic Target of Hepatocellular Carcinoma


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Precision Medicine

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE The medical and pharmaceutical industries do not yet have the capability to use simulations models to help them predict how patients will respond to drugs or drug combinations. This project focuses on improving such simulation models by combining innovative theory, computation, and experimental approaches in the context of proliferation and death of single cells.

PI_NAMEs: BIRTWISTLE, MARC R. (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Affect;Biochemical;Biology;Cancer cell line;Cell Death;Cell Line;Cell Proliferation;Cells;Cessation of life;Data;Data Set;design;Dose;Drug Combinations;drug development;Drug Industry;drug testing;Encyclopedias;Engineering;FDA approved;Fluorescence;Gene Targeting;Genetic;high dimensionality;improved;Industry;Ingestion;innovation;Mammalian Cell;Medical;Modeling;models and simulation;Molecular;Multiomic Data;Music;next generation;novel;novel strategies;Patients;Performance;Pharmaceutical Preparations;pharmacodynamic model;Pharmacologic Substance;Pharmacology;Physics;precision medicine;predicting response;Proliferating;Regulation;response;screening;Signal Transduction;Structure;synergism;Testing;theories;Time;Validation;Variant;Work

PROJECT_TITLE: Mechanistic Pharmacodynamic Modeling for Drug Combination Responses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative This T35 grant application from the Vanderbilt Student Research Training Program (SRTP) requests support for medical student research training in the areas of diabetes, obesity, digestive diseases, and kidney disease. The SRTP is affiliated with three NIDDK-supported Vanderbilt Research Centers: the Vanderbilt Diabetes Research and Training Center (DRTC), the Vanderbilt Digestive Diseases Research Center (DDRC), and the Vanderbilt Center for Kidney Disease (VCKD). We propose a comprehensive and exciting experience early in students’ medical careers that will help them make career-defining decisions.

PI_NAMEs: STAFFORD, JOHN MICHAEL (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Applications Grants;Area;base;career;Career Choice;career development;Clinical;clinical care;Country;design;Diabetes Mellitus;Digestive System Disorders;Disease;early experience;Educational Curriculum;experience;Exposure to;Faculty;Fellowship;Fire - disasters;flexibility;Funding;Goals;Grant;Hawaii;Hearing;Infrastructure;innovation;Kidney;Kidney Diseases;Leadership;Learning;Light;Medical Education;medical schools;Medical Students;Mentors;National Institute of Diabetes and Digestive and Kidney Diseases;Obesity;outreach;peer coaching;physician-scientist training program;Physicians;professor;programs;Puerto Rico;Research;Research Training;Residencies;Science;Scientist;Students;symposium;Training;Training Programs;Underrepresented Populations;United States National Institutes of Health;Visit;Work

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Aging;Diabetes;Genetics

ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE This proposal focuses on understanding the mechanisms of pancreatic β-cells senescence and the optimal strategy to therapeutically target them. Cell autonomous and non-cell autonomous mechanisms will be studied in biologically relevant models such as primary human and rodent islets. Achievement of the proposed aims will advance our knowledge of senescence biology in a highly metabolically relevant cell type with important implications for type 2 diabetes mellitus.

PI_NAMEs: AGUAYO-MAZZUCATO, CRISTINA  (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Achievement;Acute;age-related disease;Aging;B-Lymphocytes;Beta Cell;biological adaptation to stress;Biology;Blood Glucose;blood glucose regulation;CDKN2A gene;Cell Aging;Cell Physiology;cell type;Cells;Characteristics;Coupled;Cyclin-Dependent Kinase Inhibitor;Data;Development;Disease;DNA Damage;Drug Targeting;Enzyme-Linked Immunosorbent Assay;Fatty acid glycerol esters;Functional disorder;gain of function;Gene Expression;Genes;Genetic;genetic manipulation;glucose metabolism;Goals;hallmarks of aging;HIF1A gene;high body mass index;Human;human old age (65+);Impairment;improved;In Vitro;in vivo evaluation;indexing;inhibitor;insight;Insulin;Insulin Resistance;insulin secretion;islet;Knowledge;Liver;loss of function;Measurement;Metabolic;Modeling;Molecular;mouse model;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Outcome;Pancreas;Pathway interactions;Peripheral;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Predisposition;Process;Recovery;Reporter;response;Rodent;Secretory Cell;senescence;senescence associated secretory phenotype;senescent cell;senolytics;senomorphic;Stress;Structure of beta Cell of islet;Testing;Therapeutic;therapeutic target;Time;Tissues;Translating;visual tracking;Work

PROJECT_TITLE: Elucidating and targeting beta-cell senescence and its SASP

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Lay Summary  Goals of this study are to define the local factors that promote normal repair and block aberrant tissue remodeling and loss of lung function in patients with respiratory viral infections and chronic lung disease. We will define roles for alveolar epithelial lipocalin-2 in recruitment of airway basal cells to injured alveoli and roles for airway basal cells and their secreted factors in modulation of alveolar stem/progenitor cell function. Completion of this work will provide new insights into mechanisms of declining lung function in patients with acute or chronic lung disease and may allow development of novel interventions to improve outcome.

PI_NAMEs: STRIPP, BARRY R (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Acute Lung Injury;Alveolar;alveolar epithelium;Alveolus;Animal Model;Basal Cell;Basal Cell Hyperplasia;Behavior;Biological Assay;cell injury;cell motility;Cell Proliferation;Cell Transplantation;cell type;Cells;Cessation of life;Chemotaxis;ChIP-seq;Choristoma;Chronic lung disease;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Development;Distal;Economic Burden;Epithelial Cells;epithelial stem cell;Functional disorder;Genes;Genetic;Genetic Models;Goals;Human;Hyperplasia;idiopathic pulmonary fibrosis;Impairment;improved outcome;In Vitro;in vitro Model;in vivo;Individual;Infection;Inflammation;Influenza;Influenza A Virus, H1N1 Subtype;influenzavirus;injured;Injury;insight;Intervention;knock-down;LCN2 gene;Ligands;Link;loss of function;Lung;Lung Diseases;lung injury;lung repair;Mediating;Mitogens;Modeling;Molecular;mouse model;Mus;Natural regeneration;novel;Organoids;Pathway interactions;Patients;Play;Predisposition;Process;programs;Proliferating;Protein Isoforms;Pulmonary Fibrosis;pulmonary function;pulmonary function decline;recruit;Regenerative capacity;repaired;respiratory infection virus;Role;Secretory Cell;Serous;severe injury;Site;Source;Specific qualifier value;stem cell function;stem cells;Stratification;Structure of parenchyma of lung;Testing;Therapeutic;three dimensional cell culture;Tissues;transcription factor;Transfection;Viral Respiratory Tract Infection;Virus Diseases;WNT Signaling Pathway;Work

PROJECT_TITLE: Basal cells in airway and alveolar remodeling

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Two out of three people in the United States are impacted by cardiometabolic diseases (CMDs), which collectively cost the country hundreds of billions of dollars annually. Hispanics/Latinos are disproportionally afflicted by CMDs and disproportionately suffer from CMD complications. This proposal will investigate CMD trajectory arising from individual metal/metalloid exposures and their mixture in an established cohort of Hispanics/Latinos in order to identify modifiable risk factors for these conditions and to aid prevention strategies for this high risk, underrepresented population.

PI_NAMEs: SCHULZ, MARGARET  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Animals;Beta Cell;Biomedical Research;Biometry;blood glucose regulation;Blood Pressure;blood pressure elevation;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cell Physiology;Cells;Chemicals;Clinical Medicine;clinical training;cohort;Collaborations;Communities;community living;Competence;cost;Country;County;Data;Detection;Development;Diabetes Mellitus;diabetes risk;Diastolic blood pressure;Disease;disease disparity;disorder prevention;disorder risk;Education;empowerment;Environmental Epidemiology;Environmental Exposure;Environmental Health;environmental justice;epidemiologic data;Exposure to;fasting plasma glucose;Fellowship;Fostering;Foundations;Future;Genetic Predisposition to Disease;glycemic control;Glycosylated hemoglobin A;Health;health disparity;Heart Diseases;High Prevalence;high risk;high risk population;Hispanic;Hispanic Populations;Hypertension;Impairment;improved;Individual;insight;insulin sensitivity/resistance;Interdisciplinary Study;Intervention;Justice;Latino;Latino Population;Lead;lifestyle factors;lifetime risk;Link;longitudinal analysis;Measures;Mentorship;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Metal exposure;Metals;Methodology;Mexican Americans;Modeling;modifiable risk;Myocardial Infarction;non-diabetic;Not Hispanic or Latino;Nutrient;Outcome;Participant;Pathogenesis;Persons;Phenotype;Physicians;Play;Population;Population Study;Prevalence;Prevention strategy;Principal Component Analysis;Principal Investigator;prospective;Prospective cohort;Public Health;Publications;Pulse Pressure;Recording of previous events;Reduce health disparities;Regression Analysis;Regulation;Research Project Grants;Research Training;Risk;Risk Factors;Role;Scientist;skill acquisition;Solid;Stroke;Techniques;Texas;Time;Toxic Environmental Substances;Training;trait;Underrepresented Populations;United States;urinary;Vascular Diseases

PROJECT_TITLE: The Impact of Metals and Metal Mixtures on Cardiometabolic Disease Trajectories in Hispanics/Latinos

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-A(20)L]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Models of hospital addiction consultation and linkage to community-based treatment following discharge from inpatient hospitalization may be an effective approach in reducing the adverse health and economic consequences of the opioid epidemic. Information generated from economic evaluations of such healthcare models will promote successful implementation in representative public hospital settings. The goal of this project is to identify the resources/costs required to implement and sustain such a model, disseminate a costing tool for stakeholders to assess viability in their specific health system, the extent to which the intervention costs could be offset by outcomes related to increased engagement in opioid use disorder treatment, and calculate its economic value to both patients and health systems.

PI_NAMEs: JALALI, ALI  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Accounting;acute care;addiction;Adopted;Ambulatory Care;Attenuated;barrier to care;beneficiary;budget impact;Budgets;Buprenorphine;care costs;care systems;Caring;Clinical Trials;Communities;community based treatment;comparative;Consult;Consultations;cost;cost effective;cost estimate;cost-effectiveness evaluation;Data;Decision Making;economic evaluation;economic value;Economics;Effectiveness;effectiveness measure;effectiveness/implementation trial;Electronic Health Record;Ensure;Environment;evidence base;Evidence based treatment;Expenditure;Funding;Goals;Health;Health Care Costs;health care model;health care service;health care service utilization;health economics;Health Expenditures;Health Services Accessibility;Health system;Healthcare;Hepatitis C virus;Hospital Administrators;Hospitalization;Hospitals;implementation evaluation;implementation outcomes;improved;Individual;Inpatients;interest;Intervention;intervention cost;Lead;Link;Measures;Medicaid;Methadone;Modeling;Municipal Hospitals;Naltrexone;National Institute of Drug Abuse;New York City;Opioid;opioid epidemic;opioid overdose;opioid use disorder;Outcome;Outpatients;overdose death;Parents;Participant;Patients;peer;Personal Satisfaction;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Policy Maker;Population;Premature Mortality;Professional counselor;prospective;Public Hospitals;Quality-Adjusted Life Years;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research Infrastructure;Research Personnel;research to practice;Resource Allocation;Resources;safety net;secondary analysis;Services;Site;social;Social Workers;societal costs;Societies;study population;Substance Use Disorder;System;tool;treatment as usual;unemployment insurance;Use Effectiveness;Work

PROJECT_TITLE: The Economic Viability and Value of Implementing an Inpatient Addiction Consult Model in Public Hospital Systems for Patients with Opioid Use Disorder

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Estrogen;Heart Disease;Heart Disease - Coronary Heart Disease;Liver Disease;Nutrition;Obesity;Prevention;Women's Health Research

PHR: Obesity has dramatically increased the burden of cardiovascular disease, and a major goal of the NIH/NIDDK is to reduce this burden. The goal of this application is to discover how to target liver estrogen pathways to improve glucose and lipid abnormalities in obesity and diabetes, which is expected to help reverse the impact of obesity on cardiovascular risk. Our project identifies pathways that mediate sex differences in cardiovascular disease, which is also an NIH priority area.

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Anti-Inflammatory Agents;Area;atheroprotective;Atherosclerosis;Attenuated;Binding Proteins;Biology;Carbohydrates;Cardiovascular Diseases;cardiovascular risk factor;Cholesterol;Chronic;Clinical Trials;Closure by clamp;Coronary heart disease;Dependence;Diabetes Mellitus;diabetic;diet-induced obesity;Diphtheria Toxin;Disease;ESR1 gene;Estradiol;estrogenic;Estrogens;Fatty acid glycerol esters;fatty acid oxidation;Fatty Liver;Female;Funding;Glucagon;Glucose;glucose metabolism;glycemic control;Glycogen;Goals;heart disease risk;Hepatic;Hepatocyte;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Human;Hyperglycemia;Hyperinsulinism;Impairment;improved;innovation;insulin sensitivity;Isotopes;Knock-out;Knowledge;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;Long-Term Effects;male;Mediating;men;Menopause;Metabolic;Metabolic Diseases;Metabolism;Modeling;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nutrient;Obesity;Obesity associated disease;Output;Pathway interactions;Peptides;Physiology;Play;pre-clinical;Prevalence;Property;protective effect;protein activation;Response Elements;reverse cholesterol transport;Risk;Risk Factors;sex;Sex Differences;Side;Signal Transduction;Stress;Techniques;Testing;Therapeutic;therapeutic target;Tissues;Tracer;Triglycerides;United States National Institutes of Health;Very low density lipoprotein;Woman;women's outcomes

PROJECT_TITLE: Therapeutic Potential of Estrogen-Regulated Metabolism and Cardiovascular Risk

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Genetics;Human Genome;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE:  Chemical changes to our genetic information that do not change the underlying DNA sequence itself are referred to as “epigenetic” changes, and are increasingly being recognized to be altered in a wide range of lung diseases. How these epigenetic alterations contribute to the onset or progression of these diseases, and whether we can modify the epigenome to treat lung diseases remains largely unknown. This proposal will define how the SWI/SNF complex establishes patterns of chromatin accessibility (a type of epigenetic change) during development of the lung epithelium, and how these same patterns are modified by the SWI/SNF complex following repair after lung injury in the adult.

PI_NAMEs: SINNER, DEBORA ;ZACHARIAS, WILLIAM JOHN (contact)

PROJECT_TERMS: Address;Adult;Alveolar;Alveolar Cell;alveolar epithelium;Alveolus;ARID1A gene;ATAC-seq;Binding;Biological Models;Birth;Bronchopulmonary Dysplasia;Cell Differentiation process;Cell division;Cell Maturation;Cell Physiology;cell type;Chemicals;Chromatin;Chromatin Modeling;chromatin remodeling;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Code;Cre driver;CRISPR interference;Data;Data Set;Development;Disease;Disease Progression;Distal;DNA Sequence;Doxycycline;Drosophila snf protein;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Epithelial Cells;epithelial repair;epithelial stem cell;Epithelium;epithelium regeneration;Family member;Flow Cytometry;Foundations;Future;Gene Combinations;Gene Expression;genetic information;Genetic Transcription;genome-wide;Histology;Homeostasis;Human;human pluripotent stem cell;Impairment;influenza infection;Information Systems;Injury;injury and repair;LoxP-flanked allele;Lung;lung development;Lung Diseases;lung injury;lung regeneration;lung repair;Mediating;Mediator;Molecular;Mus;Neonatal Mortality;Pathogenesis;Pathologic;Pattern;Perinatal;Play;postnatal;Process;programs;Proliferating;Proteomics;pulmonary function;Regulatory Element;repaired;Respiratory distress;response;response to injury;Role;SHH gene;stem cell genes;stem cell population;stem cell proliferation;stem cells;Structure;surfactant;SWI/SNF Family Complex;System;Systems Biology;targeted treatment;Therapeutic;Time;tool;transcription factor;transcriptome sequencing;transcriptomics;translational study;Work

PROJECT_TITLE: Epigenetic Regulation of the Maturation and Function of Lung Epithelium by the SWI/SNF Proteins ARID1A and ARID1B.


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative Young sexual and gender minorities who have sex with men (YSGMSM) carry a disproportionate burden of the HIV epidemic in the United States, yet Pre-Exposure Prophylaxis (PrEP) uptake and adherence has been inadequate for these groups despite evidence that it is safe and effective at reducing HIV transmission for YSGMSM. Syndemics theory is used to characterize convergent and mutually reinforcing social (e.g., race), structural (e.g., neighborhood poverty), and digital (e.g., social media consumption, access to internet) factors impacting HIV risk in YSGMSM. This proposal incorporates this syndemics approach into iTech’s P3 study, an NICHD-funded RCT to improve PrEP adherence among YSGMSM, to understand how convergent digital and neighborhood factors impact PrEP adherence in YSGMSM.

PI_NAMEs: WILLIAMS, MICHAEL PATRICK (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Address;Adherence;adolescent HIV prevention;AIDS prevention;arm;Attenuated;Biological;Censuses;Clinic;Communities;Consumption;contextual factors;Data;Data Analyses;Data Sources;design;Development;Devices;digital;digital communication;digital intervention;effectiveness evaluation;Epidemic;Funding;Geographic Locations;Health;HIV;HIV risk;HIV/STD;Immersion;improved;Incidence;Individual;Internet;Intervention;Measures;media use;Mediation;men;Mentors;Mind;Modeling;multilevel analysis;National Institute of Child Health and Human Development;Nature;Neighborhoods;Participant;Persons;Poverty;pre-exposure prophylaxis;protective behavior;Race;Randomized, Controlled Trials;Research;Risk;Risk Factors;scaffold;sex;Sex Orientation;Sexual and Gender Minorities;Sexual Health;sexual risk behavior;sexual risk reduction;Site;social;social factors;social media;socioeconomic disadvantage;Statistical Models;structural determinants;Structure;Support Groups;Surveys;syndemic;Techniques;theories;tool;Training;Training Activity;transactional sex;transmission process;trend;Tuberculosis;United States;uptake;young men who have sex with men;Youth

PROJECT_TITLE: Neighborhood and digital immersion effects on PrEP adherence through a digital intervention in young sexual and gender minorities who have sex with men


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Pediatric;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE The goal of the proposed research is to examine fundamental biobehavioral mechanisms underlying the integrated development of an attachment-eating-feeding system in the mother-infant dyad. The proposed work will inform our understanding of how these systems co-develop and are inter-dependent, thereby providing new opportunities for intervention development.

PI_NAMEs: LUMENG, JULIE C (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 3 year old;Adult;Affective;Behavior;behavioral response;biobehavior;Biology;Birth;caregiving;Child;Childhood;cohort;Compensation;Cues;Development;Dietary intake;Distress;Eating;Eating Behavior;eating in absence of hunger;Emotional;Emotions;Exposure to;Face;feeding;Feeding behaviors;Food;Future;Goals;Growth;Heart Rate;hedonic;Hunger;Hydrocortisone;Hyperphagia;infancy;Infant;infant adiposity;Intake;Learning;Life;life span;Link;Literature;maternal caregiving;Methods;Milk;Modeling;Mothers;novel;nutrition;Obesity;obesity in children;Opioid;Oxytocin;pain relief;Physiology;predicting response;preference;Randomized, Controlled Trials;Reporting;Research;response;Rewards;Risk Factors;Satiation;Social Environment;Social Interaction;Stimulus;Stress;stressor;Sucrose;System;Systems Integration;Testing;theories;therapy development;Weight Gain;willingness;Work

PROJECT_TITLE: Fundamental Biobehavioral Mechanisms Underlying the Integrated Development of Emotion, Attachment, and Nutritive Intake in the Mother-Infant Dyad


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Regenerative Medicine

ORG_CITY: PHOENIX

ORG_NAME: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Clinical care following peripheral nerve injuries is currently limited to a “wait and watch” approach based on patient history and/or physical exam, increasing the likelihood of losing motor and sensory function following these injuries. To address this limitation, we propose a program of innovative, technical developments that will provide a set of quantitative magnetic resonance imaging parameters for characterizing peripheral nerves fol- lowing injury and after surgery. If successful, these new strategies could identify injuries that require surgery and predict surgical failures much earlier than current techniques, improving outcomes for patients with periph- eral nerve injuries.

PI_NAMEs: DORTCH, RICHARD  (contact);MAHAN, MARK ;THAYER, WESLEY P

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Acute;Address;Age;Anisotropy;Axon;axonal sprouting;behavioral outcome;Biological Assay;Biological Markers;biomarker development;biomarker discovery;Brain;Characteristics;Clinical;clinical application;clinical care;clinical decision-making;clinical trial readiness;cohort;Collaborations;computer framework;Data;density;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Early identification;Edema;Evaluation;Failure;Forearm;Goals;Histology;Human;imaging biomarker;improved;improved outcome;indexing;Inflammation;Injury;innovation;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Methods;Modeling;Monitor;Motor;Muscle denervation procedure;Muscular Atrophy;Natural regeneration;Nature;Nerve;nerve injury;Nerve Regeneration;nerve repair;nerve transection;Neuroma;Noise;novel;Operative Surgical Procedures;Outcome;Pain;Pathologic;Pathology;Patient-Focused Outcomes;Patients;Performance;peripheral nerve damage;Peripheral nerve injury;Peripheral Nerves;Phase II/III Trial;Physicians;Pre-Clinical Model;predict clinical outcome;Process;Prognosis;programs;Quality Control;Rattus;Readiness;Recommendation;Recording of previous events;Recovery;regenerative therapy;reinnervation;repaired;Repeat Surgery;Reporting;research clinical testing;Resolution;response biomarker;Scanning;Scientist;Sensitivity and Specificity;Sensorimotor functions;Sensory;Severities;sex;Signal Transduction;Site;Specificity;Surgeon;surgery outcome;Techniques;Testing;Time;Translating;Trauma;Traumatic Nerve Injury;Validation;Vendor

PROJECT_TITLE: Diffusion MRI Biomarkers of Peripheral Nerve Trauma

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative The proposed research is relevant to public health because it reveals a compensatory plasticity mechanism induced by cell death that could be harnessed as a treatment strategy to promote vision in photoreceptor degenerative diseases where compensation does not naturally occur. Secondly, this work will define the time course of constructive and destructive remodeling in the inner retina to better understand expected prognoses of retinitis pigmentosa diseases and their treatment outcomes by photoreceptor or optogenetic rescue therapies. Thus, this research is relevant to NEI’s goal to understand how plasticity and rewiring impacts signaling between photoreceptors and neurons and how this could be harnessed in degenerative disease and injury.

PI_NAMEs: VINBERG, FRANS  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Adult;Aging;Animal Model;Applied Genetics;autosome;Behavior;Birth;Blindness;Cell Death Induction;Cells;Cessation of life;Chemosensitization;Clinical Data;Compensation;Cone;Data;Degenerative Disorder;Disease;Disease Progression;Electrophysiology (science);Electroretinography;Functional disorder;functional plasticity;ganglion cell;Gap Junctions;Genes;Genetic;Glutamate Transporter;Glutamates;Goals;Human;improved;improved outcome;in vivo;Inherited;Injury;innovation;Knowledge;Life;Light;Measurement;Measures;Mediating;Methods;Modeling;Molecular;mouse model;multi-electrode arrays;Mus;Mutation;Neurons;Noise;optogenetics;Outcome;Output;patch clamp;Patch-Clamp Techniques;Pathway interactions;Patients;Perception;photoreceptor degeneration;Photoreceptors;Phototransduction;Physiological;Physiology;preservation;Presynaptic Terminals;prevent;Process;Prognosis;Property;Proteins;Public Health;Publishing;receptor;Research;Resistance;response;Retina;Retinal Degeneration;retinal neuron;Retinitis Pigmentosa;Rhodopsin;Rod;Role;sensor;sensory input;sight restoration;signal processing;Signal Transduction;single-cell RNA sequencing;stem cell therapy;Synapses;synaptotagmin I;Techniques;Testing;Therapeutic;therapy development;Time;tool;transmission process;Treatment outcome;treatment strategy;Up-Regulation;Vertebrate Photoreceptors;Vision;vision development;Western Blotting;Work

PROJECT_TITLE: Functional plasticity in retinal degenerative disease

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Koch PPG – Overall Program NARRATIVE Heart Failure remains a major health problem world-wide and there are gaps in research that are needed to be filled in order to develop innovative treatments to minimize cardiac injury and repair the failing heart. Understanding molecular mechanisms, and gender differences involved in cardiac injury and repair is imperative in order to begin to develop these novel therapies. This includes how the injured heart communicates to distant organs to create co-dependent pathologies such as cardiorenal syndrome and all projects within this Program Project have goals to move towards translating discoveries into development of novel therapies.

PI_NAMEs: KOCH, WALTER J. (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acceleration;Applications Grants;Area;Basic Science;beta-2 Adrenergic Receptors;Bone Marrow;Calcium;calcium uniporter;Cardiac;Cardiac Myocytes;cardiac repair;Cardiorenal syndrome;Cardiovascular system;Cell Death;Cell model;Cell Nucleus;Clinical;Collaborations;Communication;Communities;Complement;Complex;Data;design;Development;dimorphism;Disease;Disparate;Distant;effective therapy;endothelial stem cell;Endothelium;Epigenetic Process;Estrogens;experimental study;Female;Fostering;Functional disorder;Gender;gender difference;Genetic Transcription;Goals;GRK5 gene;Health;Heart;Heart failure;Heart Injuries;improved;in vivo;Individual;injury and repair;innovation;interest;ischemic injury;Kidney;kidney dysfunction;kidney fibrosis;Laboratory Finding;Leukocytes;male;Mediating;member;Metabolism;Mitochondria;Modeling;Molecular;mouse model;Mus;Muscle Cells;Myocardial Infarction;myocardial injury;Myocardial Ischemia;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Organ;Pathogenicity;Pathology;Pathway interactions;Phosphotransferases;Physiological;Play;precursor cell;Program Research Project Grants;programs;Property;Receptor Signaling;Regulation;repair strategy;repaired;Research;Research Personnel;response;response to injury;Role;Scientific Inquiry;Sex Differences;Signal Pathway;Signal Transduction;stem cell function;stem cells;stoichiometry;Stress;Syndrome;synergism;targeted treatment;Testing;Therapeutic;Transcript;Translating;translational impact;Treatment Failure;uptake;Viral;Viral Vector;Work

PROJECT_TITLE: Targeting Pathways Involved in Cardiac Injury for Novel Repair Strategies

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(JA)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lead Poisoning;Prevention;Social Determinants of Health

ORG_CITY: ARLINGTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

ORG_STATE: TX

PHR: Project Narrative Research on wearable sensing technologies have predominantly focused on electronics-based systems; however, the most common forms of point-of-care or at-home devices remain simple, electronics-free approaches. This project will focus on understanding and enhancing the safety and efficacy of a new class of spray-on polymeric sensor that produces a visual color change in response to target stimuli as customized by its chemical functionality. In doing so, this work toward development of a low-cost, easy-to-use, and widely deployable spray-on sensor technology platform will lead to future implementations as a discreetly wearable device for health and environmental exposure monitoring.

PI_NAMEs: JAWORSKI, JUSTYN  (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Acetone;Acute;Address;Adherence;adverse outcome;Amines;amphiphilicity;Binding;Biological Assay;biomaterial compatibility;Biomedical Technology;Breath Tests;carboxylate;Ceramics;Chemical Exposure;Chemicals;Chemistry;clinical diagnostics;Clothing;Color;Corrosion;cost;cost effective;Custom;Data;Dermal;design;Detection;Development;Devices;digital;digital divide;Dose;efficacy evaluation;Electronics;Environmental Exposure;Environmental Health;Environmental Risk Factor;Equity;Ethanol;Evaluation;experience;Exposure to;Formulation;Foundations;future implementation;Gene Expression Profiling;Health;health data;health disparity populations;Healthcare;Home;Hydrogen Bonding;Hydrophobic Interactions;Hypersensitivity skin testing;Immune response;improved;In Vitro;in vitro testing;Individual;innovation;Intention;interest;irritation;Ketosis;Lateral;lead exposure;Lead Poisoning;liquid crystal;literacy;Measures;mechanical properties;Mechanics;Metals;Modality;Modeling;Monitor;monomer;Motivation;novel;Pathway interactions;Performance;Persons;Physiologic Monitoring;Physiological;point of care;polydiacetylene;polymerization;Polymers;Population;prevent;Privacy;Property;Radiometry;Research;resilience;Resistance;response;Risk;Risk Assessment;Rotation;Safety;Self Perception;sensor;sensor technology;Skin;skin irritation;Solvents;Specific qualifier value;Specificity;Stimulus;success;Surface;surgical mask;Sweat test;System;Technology;technology platform;Testing;Textiles;Time;Toxicant exposure;Ultraviolet Rays;UV Radiation Exposure;Vertebral column;Visual;Water;wearable device;wearable health device;wearable monitor;Work

PROJECT_TITLE: A Novel Spray-On Sensing Platform Technology that Enables Wearable Visual Monitoring of Physiological Data and Environmental Exposure


PROJECT_TERMS: Adherence;Advisory Committees;Annual Reports;Biocompatible Materials;Biometry;Budgets;Collaborations;Communication;Consultations;Data;Disclosure;Documentation;Ensure;Ethics;Expenditure;experience;Guidelines;hatching;Heart Injuries;Individual;Institution;Intellectual Property;Laboratories;Lead;Leadership;medical schools;meetings;member;Names;National Heart, Lung, and Blood Institute;novel;Occupational activity of managing finances;Pathway interactions;programs;Progress Reports;Protocols documentation;Reagent;Records;repair strategy;Safety;Science;success;Travel;United States National Institutes of Health;Universities;Vertebrates;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: GAO, ERHE  (contact)

PROJECT_TERMS: Animal Model;Animals;aorta constriction;Area;Biochemical;Blood Pressure;Cardiac;cardioprotection;Cardiorenal syndrome;Cardiovascular Physiology;Cardiovascular system;Catheterization;Catheters;Cell Therapy;Cells;Chronic;Collaborations;collaborative environment;Conscious;coronary artery occlusion;Data;Data Analyses;Distant;Drug Delivery Systems;Echocardiography;exosome;experience;Experimental Designs;Functional disorder;Gene Delivery;Genes;Goals;Heart;Heart failure;heart function;Heart Injuries;hemodynamics;Histologic;implantation;in vivo;Infrastructure;Injections;Intravenous;Left ventricular structure;Measurement;Mediating;Methodology;Modeling;mouse model;Mus;Muscle Cells;Myocardial;Myocardial Infarction;myocardial injury;Myocardial Ischemia;novel;Operative Surgical Procedures;Organ;Osmosis;Pathology;Pathway interactions;Phenotype;Physiology;pressure;Program Research Project Grants;programs;Protocols documentation;Pump;repair strategy;Reperfusion Injury;Reproducibility;Research Personnel;Resources;Services;stem cell delivery;stem cells;Structure;success;Telemetry;therapeutic miRNA;Vertebral column;Viral

PROJECT_TITLE: Core B: Mouse Physiology and Surgery Core


PI_NAMEs: RAJAN, SUDARSAN  (contact)

PROJECT_TERMS: Adenoviruses;Adult;Cardiac Myocytes;Cardiorenal syndrome;Cells;Cloning;Communication;Dependovirus;Educational process of instructing;experience;experimental study;Genes;Grant;Heart failure;Heart Injuries;In Vitro;in vivo;innovation;large scale production;Lentivirus;Mus;Muscle Cells;Neonatal;novel;Organ;Pathway interactions;Preparation;Production;Protocols documentation;Rattus;repair strategy;Reproducibility;Research;Research Personnel;Resources;Services;sex;Signal Pathway;Techniques;Therapeutic;tissue culture;vector;Ventricular;Viral;Viral Vector;Virus;Work

PROJECT_TITLE: Core C: Cell and Gene Vector Core


PROJECT_TERMS: ADRBK1 gene;Animal Model;Attenuated;Binding;Binding Proteins;Biological Assay;bone cell;Bone Marrow;Calcium;Calmodulin;Cardiac;Cardiac Myocytes;cardiac repair;Cardiomyopathies;Cell model;Cell Nucleus;Cells;Cessation of life;Chromatin;Clinical;cytokine;Data;derepression;desensitization;Deterioration;Development;DNA;DNA Binding;DNA sequencing;Fibrosis;Functional disorder;G protein coupled receptor kinase;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Expression Regulation;Gene Targeting;gene therapy;Genetic Transcription;global health;GRK5 gene;Growth;Health;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;Heart Injuries;Histone Deacetylase;Human;Hypertrophy;immune cell infiltrate;immunoregulation;in vivo;Infiltration;Inflammation;Inflammatory;Injury;interest;Invaded;Ischemia;ischemic injury;Knockout Mice;Knowledge;Laboratories;Link;Mediating;Membrane;Modeling;Morphology;mouse model;Mus;Muscle Cells;Myocardial Ischemia;Myocardium;Nature;novel;novel therapeutics;Nuclear;nuclear factors of activated T-cells;Nuclear Translocation;Pathogenesis;Pathologic;Pathology;Pathway interactions;Peptides;Phenotype;Phosphorylation;Phosphotransferases;Physiological;Play;Precipitation;pressure;prevent;Regulation;repair strategy;response;response to injury;Role;Signal Transduction;Stress;Syndrome;Testing;Therapeutic;Transgenic Mice;translational approach;translational potential;Ventricular;Ventricular Remodeling;Viral

PROJECT_TITLE: Project 1: Targeting GRK5 in Cardiac Injury and Repair


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE: RELEVANCE TO PUBLIC HEALTH One of the most potentially profound, but usually overlooked, aspects of public health interventions is the possibility that the intervention will change not only the behavior of individuals in a community, but the social structure of the community itself, even affecting people who were not targets of the intervention. This project will build on an existing RCT and create a new and very unusual dataset, capturing how the structures of real-world networks and the position of aging adults within them change over time in response to a randomized exposure to a health intervention. We will use this data set to answer important questions about how the positions, roles, and health of older adults are affected by public health interventions. !

PI_NAMEs: CHRISTAKIS, NICHOLAS A (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Adopted;Adoption;Adult;Affect;Age;aged;Aging;Algorithms;Attenuated;Behavior;Caring;Cessation of life;Child Health;Child Rearing;Communities;Data;Data Set;Diffuse;Diffusion;dosage;Dose;Educational Intervention;Ego;Elderly;experience;Exposure to;Friends;Health;health practice;Health system;Honduras;Individual;Information Networks;Institution;Intervention;intervention effect;Lead;Maintenance;Maps;marginalization;Maternal Health;Measures;Mental Health;Methods;neonatal health;novel;older adult;Older Population;Parents;Participant;pathogen;Penetrance;Personal Satisfaction;Persons;physical conditioning;Play;Positioning Attribute;Process;Public Health;public health intervention;Randomized;rate of change;response;Role;Rural;Shock;Smoke;smoking cessation;social;Social Change;social contact;Social isolation;Social Network;social relationships;social structure;Societies;Sorting;Source;statistics;Structure;System;Testing;Textiles;Time;Work

PROJECT_TITLE: Effects of Public Health Interventions on Aged Adults in Village Social Networks

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Estrogen;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Women's Health Research

PI_NAMEs: KISHORE, RAJ  (contact)

PROJECT_TERMS: Age;angiogenesis;Area;Autologous;Bone Marrow;Bone Marrow Involvement;Cardiac;cardiac repair;cardioprotection;Cardiovascular Diseases;Cells;Chimera organism;Clinical Trials;Complication;Data;dimorphism;Disease;Disparate;Disparity;DNA Methylation;endothelial stem cell;Enzymes;Epigenetic Process;Equation;Estrogens;exosome;Experimental Animal Model;experimental study;Exposure to;Female;female sex hormone;gain of function;Gender;gender disparity;Gonadal Hormones;Gonadal Steroid Hormones;Heart failure;Heart Injuries;histone methylation;Histones;Homeostasis;Homing;Hormones;improved;In Vitro;Incidence;Infarction;Infiltration;Inflammatory;Infusion procedures;Injections;Injury;Investigation;Ischemia;ischemic injury;Left Ventricular Dysfunction;Literature;loss of function;Lysine;male;Mediating;men;Mesenchymal Stem Cells;Methylation;migration;Modality;Molecular;mortality;Mus;Myocardial;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Natural regeneration;Neonatal;neovascularization;novel;novel therapeutic intervention;Ovariectomy;Parents;Pathway interactions;patient population;Patients;Phenotype;Physiological;Play;Population;Postmenopause;preservation;Process;progenitor;Proliferating;Property;Recovery of Function;recruit;repair strategy;repaired;Reporting;reproductive;Research;response;Role;Severities;sex;Signal Transduction;stem cell function;stem cell therapy;Stem cell transplant;stem cells;stemness;Structure;Supplementation;therapeutic evaluation;tissue repair;Transferase;Transgenic Organisms;Transplantation;Treatment Efficacy;Tube;Woman

PROJECT_TITLE: Project 2: Gender Dimorphism in Bone Marrow Endothelial Progenitor Cell-mediated Post-Infarct Myocardial Repair


ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative. Inefficient communication among providers and caregivers of community-dwelling persons living with dementia (PLWD) can allow minor health issues to escalate into medical emergencies, resulting in increased hospitalizations, emergency department visits, and significant costs to health systems. The proposed application supports the Principal Investigator in acquiring requisite training to inform the development and preliminary testing of a user-centered mobile health (mHealth) application that facilitates communication among adult day service centers, caregivers, and primary care providers around the needs of PLWD. In doing so, this study works toward national goals of reducing fragmentation in health care delivery, optimizing care quality and efficiency, and expanding support for PLWD and their families, especially those in diverse communities.

PI_NAMEs: SADARANGANI, TINA  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: acceptability and feasibility;Access to Information;Acute;Address;Adoption;Adult;Alzheimer's Disease;Alzheimer's disease related dementia;Area;behavior test;Behavior Therapy;Caregivers;Caring;Categories;chronic care model;Clinical;Communication;Communities;community based care;community setting;Continuity of Patient Care;cost;Country;Data;Dementia;Dementia caregivers;design;Development;Disparity;disparity reduction;Early Diagnosis;Early Intervention;efficacy testing;eHealth;electronic health record system;Elements;Emergency department visit;Enrollment;experience;facsimile;Family;feasibility testing;Feedback;Focus Groups;functional status;Future;Goals;Growth;handheld mobile device;Health;health care delivery;health care service utilization;health care settings;health information technology;Health Status;Health system;Health Technology;Healthcare;Hospital Costs;Hospitalization;improved;Individual;informal caregiver;innovation;integrated care;Integrated Health Care Systems;interoperability;Intervention;Interview;Knowledge;Low income;Maps;Medical;Medical emergency;Medical Records;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;mHealth;mhealth interventions;Minor;Mobile Health Application;Modeling;Notification;novel;Nurses;older adult;Outcome;Patients;Persons;poor health outcome;Positioning Attribute;Predisposition;primary care provider;Principal Investigator;Process;product development;programs;prototype;Provider;Public Health Practice;Quality of Care;racial diversity;racial minority;Random Allocation;Registered nurse;Research;Research Personnel;Resources;Scientist;Services;smartphone application;social;Social Workers;Statutes and Laws;Surveys;Technology;Testing;therapy development;Time;Training;Treatment Efficacy;United States;United States National Institutes of Health;user centered design;Visual;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: Leveraging mobile health technology to reduce avoidable healthcare utilization in persons with Alzheimer's Disease and Related Dementias in adult day centers

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


PI_NAMEs: TILLEY, DOUGLAS  (contact)

PROJECT_TERMS: Affect;American;beta-2 Adrenergic Receptors;beta-adrenergic receptor;beta-arrestin;Cardiac;Cardiorenal syndrome;Cells;Cessation of life;Characteristics;Clinical;clinically relevant;Communication;cost;cytokine;Detection;Development;Disease;EFRAC;Environment;Fibroblasts;Fibrosis;Flow Cytometry;fundamental research;G protein coupled receptor kinase;G-Protein-Coupled Receptors;Genetic;Healthcare;Heart;Heart failure;Heart Injuries;hemodynamics;Human;Immunohistochemistry;Infiltration;Injury;insight;Intervention;Kidney;kidney cell;kidney dysfunction;kidney fibrosis;Laboratories;Leucocytic infiltrate;leukocyte activation;Leukocyte Trafficking;Leukocytes;Lymphocyte;Macrophage;Measurable;Mediating;Molecular;monocyte;mortality;Mus;Myocardial dysfunction;Myocardium;Neurohormones;neutrophil;novel;novel strategies;Organ;Pathway interactions;Patients;peripheral blood;pharmacologic;Phosphotransferases;Physiological;Play;Population;Prevalence;prevent;Prevention;Process;Prognosis;receptor;receptor expression;Receptor Signaling;recruit;Regulation;repair strategy;Reporting;Resources;response;Risk Factors;Role;Severity of illness;Signal Transduction;single-cell RNA sequencing;specific biomarkers;Structure;Sympathetic Nervous System;System;Therapeutic;Transcript;transcriptome;treatment strategy;Venous

PROJECT_TITLE: Project 3: Leukocyte-Mediated Regulation of Cardiorenal Syndrome


NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative This is a proposal to renew, for its 41st through 45th years, a postdoctoral research training grant that prepares young scientists to succeed as independent investigators conducting behavioral pharmacology research to understand and treat problems related to substance use and abuse.

PI_NAMEs: STRAIN, ERIC C. (contact);STRICKLAND, JUSTIN CHARLES;WEERTS, ELISE M

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: behavioral pharmacology;Human;Substance abuse problem

PROJECT_TITLE: Human Behavioral Pharmacology of Substance Abuse


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Genetics;Human Genome;Lung;Prevention;Tobacco;Tobacco Smoke and Health

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE In some genes the sequence which is read (“expressed”) in a cell can be altered by a mechanism known as RNA splicing. In this study, we will identify genetic variants that contribute to chronic obstructive pulmonary disease (COPD) by altering RNA splicing. This will result in greater understanding of the ways that genetic factors contribute to COPD, and this information might be used to identify and develop new COPD treatments.

PI_NAMEs: SAFERALI, AABIDA  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Address;Alleles;Alternative Splicing;Biological;Biometry;Blood;Blood specimen;career;case control;Cause of Death;Cells;Chronic Obstructive Pulmonary Disease;cigarette smoking;Clinical Management;Complement;Data;Data Set;Development;Disease;Disease susceptibility;disorder risk;Doctor of Philosophy;Drug Targeting;Environmental Risk Factor;experience;FDA approved;Gene Expression;Gene Expression Regulation;gene product;Generations;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;genetic variant;genome wide association study;genome-wide analysis;genomic locus;Genomics;Genotype;Goals;improved;innovation;insight;Knowledge;Length;Lung;Lung Diseases;Mentors;Methodology;novel;Nucleic Acid Regulatory Sequences;Pathogenesis;Pathway interactions;Pattern;personalized approach;Phenotype;Play;Protein Isoforms;pulmonary function;Quantitative Trait Loci;Research;Research Design;Research Personnel;Research Priority;respiratory;Respiratory Disease;RNA Splicing;Role;Sampling;skills;Smoker;Smoking;Spliced Genes;Structure;Structure of parenchyma of lung;success;Susceptibility Gene;targeted treatment;Techniques;Testing;Tissue Sample;Tissues;Training;Transcript;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;Variant;Whole Blood;Work

PROJECT_TITLE: Integrative 'Omics of Transcriptome Complexity in COPD

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


PI_NAMEs: ELROD, JOHN WILLIAM (contact)

PROJECT_TERMS: Ablation;Acute;acute stress;Adult;American;Animals;Biophysics;Calcium;calcium uniporter;Cardiac;Cardiac Myocytes;cardioprotection;Cell Death;Cell Line;Cells;Cessation of life;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;conditional mutant;Data;Development;Disease;EF Hand Motifs;Event;fast protein liquid chromatography;fighting;Follow-Up Studies;gain of function;Genes;Genetic;Heart failure;heart function;Heart Injuries;heart metabolism;Human;In Vitro;in vivo;in vivo Model;Individual;Infusion procedures;Injury;Inner mitochondrial membrane;interest;Ischemia;Isoproterenol;Knock-in;Knockout Mice;Left;loss of function;Mediating;member;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;mitochondrial permeability transition pore;Modeling;Molecular;Molecular Weight;Monitor;mouse model;Mus;mutant;mutant mouse model;Mutant Strains Mice;Myocardial Infarction;Myocardial Reperfusion Injury;Necrosis;novel;novel therapeutics;overexpression;paralogous gene;Pathogenicity;Pathway interactions;peptidomimetics;pharmacologic;Physiologic intraventricular pressure;Physiological;Physiology;Property;Proteins;Proteomics;Protocols documentation;Recurrence;Regulation;repair strategy;Reperfusion Injury;Reporting;response;Role;scaffold;stoichiometry;Stress;Survivors;Tamoxifen;theories;Therapeutic;translational potential;uptake;Workload

PROJECT_TITLE: Project 4: Mitochondrial Uniporter Regulation can Limit Ischemic Damage


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PHR: PET and calcium imaging with fiber photometry will be used to investigate how alterations in dopamine D3 receptor and metabotropic glutamate receptor 5 (mGlu5) signaling impact cocaine-relevant decision-making behaviors in rats. Aim 1 will investigate the relationship between individual differences in midbrain dopamine D3 and neural activity in meso-cortico-limbic circuits during decision making and cocaine self-administration. Aim 2 will assess neural activity in select cortico-striatal circuits during decision making before and after cocaine to determine how disruptions in mGlu5 signaling mediate addiction-relevant (seeking/taking) behaviors and alter decision-making behavior.

PI_NAMEs: TAYLOR, JANE R (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Abstinence;addiction;Affect;Amygdaloid structure;Behavior;Behavioral;Binding;biobehavior;Biological Markers;Calcium;Chronic;Cocaine;Cocaine Dependence;cocaine exposure;cocaine self-administration;cocaine use;Cocaine use disorder;Computer Analysis;Corpus striatum structure;cortico-limbic circuits;Data;Decision Making;Development;Dopamine;dopamine D3 receptor;Drug Exposure;drug seeking behavior;drug testing;Drug usage;Fiber;Funding;Future;glutamatergic signaling;Human;Image;Impairment;Impulsivity;in vivo;Individual;Individual Differences;Learning;Link;Mediating;Mediator;metabotropic glutamate receptor 5;Midbrain structure;Modeling;neural;neural circuit;neurobiological mechanism;Neurobiology;neuroimaging;novel strategies;Nucleus Accumbens;Outcome;Pathology;Pharmaceutical Preparations;Photometry;Positron-Emission Tomography;Predisposition;Prefrontal Cortex;Process;Psychological reinforcement;Publishing;Rat Transgene;Rattus;receptor;Relapse;Reporting;Reversal Learning;Rewards;Role;Signal Transduction;Testing;Transgenic Organisms;Tyrosine 3-Monooxygenase;Up-Regulation;Update;Variant

PROJECT_TITLE: Individual Differences & Cocaine Effects on Impulsive Choice in Rat

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Polygenic Risk Scores (PRS) combine information across numerous genetic variants to improve disease prediction; however, lack of diversity in PRS research to date threatens applicability in non-European ancestry individuals. The NHGRI Polygenic Risk Score Diversity Consortium will conduct collaborative data integration, analysis, and methods development in existing research cohorts to improve PRS prediction across diverse populations. As Coordinating Center for the Consortium, we will perform genotype and phenotype data harmonization, lead collaborative analysis, contribute to methods development, help identify Ethical, Legal, and Social Implications (ELSI) of PRS, facilitate data sharing, and coordinate program logistics and outreach.

PI_NAMEs: RICE, KENNETH M. (contact)

PROGRAM_OFFICER_NAME: MINEAR, MOLLIE A

PROJECT_TERMS: Address;Adoption;Biomedical Research;Catalogs;Circulation;Clinical;clinical implementation;clinical risk;clinical translation;cloud based;cloud storage;cohort;Communities;Consensus;Data;data access;data harmonization;data integration;Data Science;Data Set;data sharing;database of Genotypes and Phenotypes;Development;Disease;disorder risk;Documentation;Ensure;Environmental Risk Factor;epidemiology study;ethical, legal, and social implication;Ethics;ethnic minority population;Ethnic Population;European;Evaluation;experience;FAIR principles;Gene Frequency;Generations;Genetic;genetic variant;Genetic Variation;genomic data;Genomics;Genotype;Goals;Health;Health Benefit;health care disparity;high risk;Human;improved;Individual;Informatics;innovation;Knowledge;Lead;Leadership;Linkage Disequilibrium;Logistics;meetings;member;Mentorship;method development;Methodology;Methods;National Human Genome Research Institute;Ontology;outreach;outreach program;Pattern;Performance;Persons;Phenotype;phenotypic data;Policies;policy implication;polygenic risk score;Population;Population Heterogeneity;portability;precision medicine;predictive tools;prevent;Procedures;programs;Progress Reports;Public Health;Quality Control;racial minority population;racial population;Reporting;repository;Research;Resource Development;Resources;Rest;Risk;Risk Factors;Sampling;Scoring Method;screening;Site;social implication;Source;Standardization;targeted treatment;tool;Training;training opportunity;Translations;Variant;Visualization;web site

PROJECT_TITLE: Polygenic Risk Score Diversity Consortium Coordinating Center


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Health Services;Mental Health;Palliative Care;Patient Safety;Prevention

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Approximately 1 in 4 deaths among elderly patients in the U.S. occur following an ICU admission, during which patients often spend their final days incapacitated and connected to various forms of life support. These patients’ family members suffer psychological distress when faced with decisions about whether to transition from life-prolonging treatment to comfort-focused treatment when it becomes clear that a patient’s health goals cannot be achieved. We will conduct a randomized trial to determine whether a scalable, interactive tool can help lessen the psychological burden on family members and improve the quality of care provided older adults in ICUs.

PI_NAMEs: WHITE, DOUGLAS B (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Academy;Admission activity;Advance Care Planning;advanced disease;Affect;Affective;American;anxiety symptoms;Caring;Cessation of life;Clinical;clinical research site;Cognitive;Communication;Conceptions;contextual factors;coping;cost;Critical Illness;Decision Aid;Decision Making;Decision Theory;depressive symptoms;disability;efficacy evaluation;efficacy trial;Elderly;Emotional;emotional experience;end of life;Enhancement Technology;evidence base;Evidence based intervention;expectation;Exposure to;Family;family burden;Family member;family support;follow-up;Fright;Goals;Guilt;Health Care Costs;health care service utilization;health goals;high risk;Human Resources;Impairment;improved;innovation;instrument;Intensive Care Units;interactive tool;Intervention;Length;Length of Stay;Letters;Life;Literature;Measures;Medicine;Modernization;mortality risk;older adult;older patient;Outcome;patient navigation;patient oriented;Patient-Centered Care;Patients;pilot test;post-traumatic stress;preference;prevent;primary outcome;Process;Prognosis;prognostic;psychologic;psychological distress;psychological outcomes;Public Health;Qualitative Research;Quality of Care;quality of death;Quality of life;randomized trial;randomized, clinical trials;Research;Research Personnel;safety outcomes;Site;Specialist;success;support tools;surrogate decision maker;tool;treatment as usual;United States National Institutes of Health;web-based tool;willingness;Work

PROJECT_TITLE: Randomized Trial of a Scalable, Interactive Tool to Support Surrogate Decision-makers of Elderly Critically Ill Patients

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Data Science;Genetics;Human Genome

ORG_DEPT: GENETICS

PHR: Narrative The genomics workforce faces a shortage of people with data science skills and is also lacking diverse representation. These problems impact the quality of research being conducted, and the lack of diversity leads toward both explicit and implicit bias within genomics data sets and among those conducting research. The UW-GRTDS will address these problems by recruiting diverse trainees with data science skills, thereby helping to diversify the genomics workforce and promoting a higher quality of genomics research for the benefit of human health.

PI_NAMEs: DOBRA, ADRIAN ;NOBLE, WILLIAM STAFFORD (contact)

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Advocate;anti-racism;Area;career;career development;Career Mobility;career networking;Communities;community building;Data Science;Data Scientist;design;educational atmosphere;effectiveness evaluation;Elements;Ensure;Environment;Equity;Event;experience;explicit bias;Face;faculty mentor;Future;genome sciences;genomic data;Genomics;Goals;graduate student;Health;Human;implicit bias;Institution;Knowledge;Laboratories;Laboratory Research;Learning;marginalization;Mentors;Mentorship;Minority Groups;Monitor;National Human Genome Research Institute;Participant;Pathway interactions;Persons;Program Effectiveness;programs;recruit;Research;research faculty;Research Personnel;Research Training;Running;Self Efficacy;Shapes;skills;statistics;Strategic Planning;student participation;Students;support network;supportive environment;Training;training data;Underrepresented Minority;underrepresented minority student;Universities;Washington;Work

PROJECT_TITLE: University of Washington Genomics Research Training for Data Scientists


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Alzheimer’s disease (AD) is the most common form of dementia worldwide and is characterized by the presence of extracellular senile plaques in the brain that are composed of aggregations of small peptides called beta- amyloid (Aβ). We hypothesize that microglia, which are the immune cells of the brain, contribute to clearance of Aβ via a process called autophagy, but this process is impaired in AD. Here we will examine how specific small non-coding RNAs (miRNA) alter expression of key proteins that participate in autophagy process and we will test whether reducing the expression of a specific miRNA can correct autophagy, restore degradation of Aβ, and reduce AD pathobiology.

PI_NAMEs: AMER, AMAL O (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3' Untranslated Regions;abeta accumulation;Abeta clearance;abeta deposition;Adult;Age;age related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid beta-Protein;Astrocytes;Autophagocytosis;Behavior;Binding;Brain;brain cell;Cells;Chronic;Data;Defect;Dementia;Deposition;Deterioration;Down-Regulation;Equilibrium;Eukaryotic Cell;experimental study;Exposure to;extracellular;Genetic Transcription;Homeostasis;Human;human disease;Hyperactivity;Immune;Impaired cognition;Impairment;improved;In Vitro;in vivo;Individual;Ingestion;inhibition of autophagy;Injections;ITGAM gene;Knowledge;Mannose;Mediating;member;Memory;Memory Loss;Microglia;MicroRNAs;Modeling;Molecular;mouse model;Mus;nanolabel;nanoparticle;Nerve Degeneration;Neurons;neuroprotection;neurotoxicity;new therapeutic target;novel strategies;Peptides;Phase;prevent;Preventive measure;Process;Production;Proteins;Publishing;receptor;Reporting;response;Role;Sampling;Senile Plaques;sex;Signal Pathway;Sirolimus;tau Proteins;Testing;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Tissues;Transcript;transcription factor;Untranslated RNA;Up-Regulation;Vacuole

PROJECT_TITLE: Targeting specific MicroRNA to alleviate Alzheimer’s Disease pathobiology


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: NARRATIVE South Africa has among the highest incidence of HIV-associated tuberculosis in the world, with this condition and COVID-19 being leading causes of death in South Africa. This application seeks renewal of the Fogarty HIV- associated Tuberculosis Training Program through which the University of Cape Town is partnering with Vanderbilt University Medical Center and Johns Hopkins University to provide research training opportunities to develop the next generation of researchers working on the epidemiology, treatment issues and immunology of HIV and tuberculosis as well as HIV and COVID-19 interactions. In this Training Program we will place strong emphasis on training clinician scientists/researchers, attracting medical students to HIV-associated tuberculosis and HIV-associated COVID-19 research, and on demographic transformation of the research platform to redress disparities persisting from apartheid.

PI_NAMEs: MEINTJES, GRAEME AYTON (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Advisory Committees;analytical method;Area;Award;Biometry;career;clinical epidemiology;Clinical Immunology;co-infection;Collaborations;COVID-19;Development;Disease;Disparity;Doctor of Philosophy;Drug Hypersensitivity;Drug Kinetics;Epidemic;Epidemiology;Evaluation;Feedback;Fellowship;genetic epidemiology;Grant;HIV;HIV/TB;Immune;improved;Individual;Institution;Intervention;Laboratories;Learning;Lifting;Medical Students;meetings;member;Mentorship;Modeling;Molecular;next generation;novel;Online Systems;Outcome;Output;Pathogenesis;Performance;Pharmacogenetics;Postdoctoral Fellow;Process;Productivity;programs;Protocols documentation;Reporting;Research;Research Personnel;Research Training;responsible research conduct;Scientist;Structure;Students;success;summer institute;symposium;Talents;Training;training opportunity;Training Programs;Tuberculosis;tuberculosis drugs;Universities;Update;Writing

PROJECT_TITLE: HIV-associated Tuberculosis Training Program (HATTP)


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This R25 Research Education Program (renewal of R25 AG053227) proposes to continue both the annual week- long summer workshop on integrating genomic and social science data, Genomics for Social Scientists (GeSS), as well as the annual 4-day course specifically focused on epigenetic data. These two annual courses, a series of online modules, and web-based resources will continue to build the capacity of social and behavioral scientists of aging to understand and collaborate on genomic research using NIH-funded resources, such as the Health and Retirement Study. Investing in the education of social and behavioral scientists and developing tools and trainings that are relevant to their entry into genetic research will more fully realize the potential of the millions of dollars that have been spent on adding biological data to social science studies.

PI_NAMEs: FAUL, JESSICA  (contact);MITCHELL, COLTER M.S.;WARE, ERIN BAKSHIS

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;Adolescent;Adult;Aging;aging mechanism;aging related;Area;Behavioral;behavioral and social science;Biological;Biological Assay;Biological Sciences;Biology;Biosocial;Code;Collaborations;Collection;Communities;Complement;Complex;cost;Custom;Data;Data Files;Databases;Discipline;diversity and inclusion;DNA;DNA Methylation;Education;education research;Educational process of instructing;Educational workshop;Electronic Mail;Epigenetic Process;Evaluation;Exercise;experience;Funding;Generations;Genes;Genetic;Genetic Research;Genetic study;genome resource;genome sciences;genomic data;genomic predictors;Genomics;Gerontology;Goals;Health;Health and Retirement Study;health disparity;Health Sciences;Human;improved;Infrastructure;Instruction;interest;Internet;Investments;Knowledge;Language Development;learning materials;Length;Link;Longitudinal cohort study;Longitudinal Studies;Measures;meetings;Mentors;Methodology;Methods;Modeling;Molecular;National Longitudinal Survey of Adolescent to Adult Health;Northern Ireland;online resource;online tutorial;Outcome;Participant;Persons;Phenotype;phenotypic data;Population;population based;Population Study;portability;prediction algorithm;programs;Protocols documentation;Publications;Publishing;Quality Control;Race;Reporting;Research;Research Methodology;Research Personnel;Resources;sample collection;Sampling;Scientist;Secure;Series;skills;social;social factors;social genomics;social science research;Social Sciences;Societies;Statistical Methods;Students;Surveys;symposium;telomere;theories;tool;Training;trait;Translating;United States National Institutes of Health;virtual;web site

PROJECT_TITLE: Genomics for Social Scientists: 2022-2027