NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Women's Health Research

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Ploidy altering mechanisms such as cell-cell fusion and whole genome doubling (WGD) can drive intratumoral heterogeneity and may play a prominent role in chemotherapeutic response. We will use expressed DNA barcodes to longitudinally dissect the rates and roles of pre-existing aneuploidy and therapy-induced ploidy alteration at single cell resolution and multi-scale data will be used to parameterize and validate a predictive model of therapeutic response. In systematically investigating mechanisms of ploidy alteration at a single cell resolution, we may reveal therapeutically targetable drivers of genome instability with radical implications for the treatment and prognosis of TNBC.

PI_NAMEs: GARDNER, ANDREA L (contact)

PROJECT_TERMS: Aftercare;Aneuploidy;Bar Codes;Breast Cancer Cell;Breast Cancer cell line;breast cancer diagnosis;Breast Cancer Model;Breast Cancer Patient;Calibration;cancer cell;Cell Culture Techniques;cell determination;Cell fusion;Cell model;Cells;Chemoresistance;chemotherapy;Chromosomal Instability;clinically relevant;Clonality;Coculture Techniques;Color;Data;Discrimination;DNA;driving force;Effectiveness;ERBB2 gene;Estrogens;Event;Evolution;experimental study;fluorophore;forging;Gene Expression;Generations;Genome Stability;Genomic Instability;Heterogeneity;hormone therapy;Human;improved;in silico;indexing;Individual;Label;Libraries;Link;live cell imaging;Malignant Breast Neoplasm;Malignant Neoplasms;mathematical model;Measurement;Methods;Modeling;Molecular;mortality;multiple omics;multiscale data;novel;Nucleotides;overexpression;Patient-Focused Outcomes;Patients;Pattern;Phenotype;Play;Ploidies;Population;Population Heterogeneity;Prediction of Response to Therapy;predictive modeling;Progesterone;Prognosis;receptor;Recovery;Relapse;Resistance;Resolution;response;Role;Sampling;Schedule;Selection for Treatments;Series;single cell sequencing;single-cell RNA sequencing;Solid Neoplasm;Stains;standard of care;Stress;System;targeted treatment;Techniques;Testing;Therapeutic;Therapeutically Targetable;therapy outcome;therapy resistant;Time;transcriptomics;Treatment Failure;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor heterogeneity;Update;Visualization;whole genome

PROJECT_TITLE: Systems Approaches to Understanding the Impact of Cell-Cell Fusion on Therapeutic Resistance


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: DALLAS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Despite its significant health care burden, no targeted therapies are available for the treatment of Fragile X Syndrome and specifically the autism spectrum disorder-related behaviors in Fragile X Syndrome, as the mechanisms underlying these disorders remain poorly understood. In this proposal we will delineate the cerebellar contribution to autism-relevant behaviors in Fragile X Syndrome and delineate the underlying mechanisms and therapeutic benefits of cerebellar genetic and circuit-based strategies to improve autism- relevant behaviors in multiple mouse models for Fragile X Syndrome.

PI_NAMEs: TSAI, PETER T. (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Acute;Applications Grants;association cortex;autism spectrum disorder;Automobile Driving;Behavior;Behavior Disorders;Behavioral;Cell Physiology;Cerebellar Diseases;Cerebellum;Child;Data;Decision Making;Development;disability;Disease;Electrophysiology (science);Evaluation;eyeblink conditioning;Fragile X Syndrome;Functional disorder;Genetic;Genetic Models;Healthcare;healthcare burden;Hypersensitivity;Image;Impairment;improved;in vivo;Individual;Injections;Knock-out;Lifestyle-related condition;Link;Lobule;Mediating;Modeling;Molecular;molecular targeted therapies;Morphology;mouse model;mutant;mutant mouse model;Mutant Strains Mice;mutation carrier;Nervous System Physiology;neural;Neurocognitive;Neurodevelopmental Disorder;neuroregulation;Parietal;Pathogenesis;Pathology;Pathway interactions;Phenotype;Physiology;Play;pre-clinical;Prevalence;Purkinje Cells;Regulation;restoration;Role;Sensory;Slice;social;social deficits;Subcellular Anatomy;Synaptic plasticity;targeted treatment;Therapeutic;therapy development;Tremor/Ataxia Syndrome;United States;Viral

PROJECT_TITLE: Cerebellum and cerebellar-regulated circuit contribution to Fragile X Syndrome

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Genetics;Human Genome;Microbiome;Natural Products;Nutrition;Prevention

ORG_CITY: FARMINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: NARRATIVE Our approach incorporates personalized nutrition within the context of colonic health and focus on UroA producers and non-producers. Ultimately, our human and pre-clinical mouse studies may lead to prebiotics and probiotics that increase protective urolithins for CRC prevention. These studies are of high significance as they will test the ability of the microbiota to generate agents (e.g., UroA) protective of the colonic mucosa, converting high-risk patients to a protective state by taking probiotics, thereby realizing the full benefits of ET-rich foods.

PI_NAMEs: JOBIN, CHRISTIAN ;ROSENBERG, DANIEL WILLIAM (contact)

PROGRAM_OFFICER_NAME: KUMAR, AMIT

PROJECT_TERMS: adenoma;Age;anti-cancer;Anti-Inflammatory Agents;Antioxidants;arm;Bacteria;bile acid metabolism;Bile Acids;Biological Markers;Blood;Cancer Model;cancer prevention;cancer risk;Colon;Colonic Neoplasms;Colonoscopy;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Colorectal Neoplasms;Complex;Consumption;Cross-Over Studies;Cross-Over Trials;Development;Diet;dietary control;Dietary History;DNA sequencing;Eligibility Determination;Ellagi-Tannins;Ellagic Acid;Exhibits;Fatty Acids;fecal transplantation;Feces;Food;Generations;Goals;gut bacteria;gut microbiota;Health;high risk;Human;human study;improved;Incidence;Individual;Inflammation;Inflammatory;inflammatory marker;inter-individual variation;interest;Juglans;Lesion;Malignant Neoplasms;Measures;Metabolic;Metabolism;Microbe;microbial colonization;microbiome;microbiome composition;microbiota;microbiota metabolites;microbiota transplantation;Mitogen-Activated Protein Kinases;Modification;mouse model;Mucous Membrane;Mus;Oncogenic;Pathway interactions;Patients;personalized nutrition;Phase;Phytochemical;polyphenol;Polyps;pre-clinical;prebiotics;Preventive;probiotic supplementation;Probiotics;Process;Production;Property;Protective Agents;protective effect;Randomized;recruit;Risk;Risk Factors;Role;Schedule;screening;Serrated Adenoma;Signal Transduction;Source;stool sample;Supplementation;Tamoxifen;Testing;transcriptome sequencing;Transplantation;tumor;tumor initiation;tumorigenesis;urinary;Urine;Volatile Fatty Acids

PROJECT_TITLE: Microbiota, Metabolites, and Colon Neoplasia

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The mammalian SWI/SNF complexes are multi-subunit protein assemblies that play critical roles in establishing and maintaining DNA accessibility and gene expression. I aim to define the role of a newly-described, mammalian-specific subunit, BCL7, in SWI/SNF complex function in the human cell context with respect to a) SWI/SNF complex biochemical integrity; and b) SWI/SNF genome-wide chromatin targeting and DNA accessibility generation in B cell lymphomas and normal primary B cells. This research will elucidate new mechanisms of mSWI/SNF activity and its role in the regulation of gene expression in normal and disease states.

PI_NAMEs: HIXON, KIMBERLEE  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Affect;Amino Acids;Antibodies;Architecture;ATAC-seq;ATP Hydrolysis;ATP phosphohydrolase;B cell differentiation;B-Cell Lymphomas;B-Lymphocytes;Binding;Biochemical;Biological Assay;cancer subtypes;Cell Differentiation process;cell fate specification;Cell Line;Cell Maturation;Cell Physiology;Cell surface;Cells;Chromatin;chromatin immunoprecipitation;Chromatin Remodeling Factor;Chronic Lymphocytic Leukemia;Cleavage Under Targets and Release Using Nuclease;Combinatorics;Complex;Computer Analysis;Dedications;Development;Disease;DNA;Evolution;Family;Gene Expression;Gene Expression Regulation;gene product;Generations;Genes;Genetic Transcription;genome-wide;Genomic approach;Genomics;Human;human disease;Immune system;Immunoprecipitation;Infection;Knock-out;large cell Diffuse non-Hodgkin's lymphoma;Length;Link;Lymphoma;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mammalian Cell;Mediating;Multiple Myeloma;Multiprotein Complexes;Mutate;Mutation;N-terminal;Neurodevelopmental Disorder;Nucleosomes;Oncogenic;Organism;Pathogenesis;Physiological Processes;Play;Process;programs;Proliferating;protein complex;Protein Subunits;Research;Role;Series;Site;SMARCA4 gene;SMARCC1 gene;SWI/SNF Family Complex;Systems Development;Tissues;transcriptome sequencing;Transposase;tumorigenesis;Variant;vector;vector control;Western Blotting

PROJECT_TITLE: Defining the role of the BCL7 subunit of mammalian SWI/SNF chromatin remodeling complexes in human cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Mental Health;Mental Illness;Pediatric;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: RICHMOND

ORG_DEPT: SURGERY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative: Research on CD and CU traits has increased greatly in recent years, yet, the mechanisms underlying CU traits in this high-risk population remain poorly understood. Our research strategy integrates cutting edge virtual reality fear induction technology while measuring multiple physiological indices in youth with CD to differentiate boys and girls with varying levels of CU traits. The outcomes from this research will provide a more accurate physiological fear profile for youth with CU traits, which will lead to improvements in gender-responsive intervention strategies, with the ultimate aim of early detection and prevention.

PI_NAMEs: THOMSON, NICHOLAS DAVID (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;Age;Aggressive behavior;antisocial behavior;Appearance;Arousal;Autonomic nervous system;Behavior;Behavioral;Biological;Biological Markers;boys;callous unemotional trait;Cardiovascular system;CD6 antigen;Child;Chronic;Clinical;Conduct Disorder;criminal behavior;Data;Development;Disease;Early Diagnosis;Electromyography;emotion dysregulation;Emotional;emotional stimulus;Emotions;Empathy;Etiology;experience;externalizing behavior;Face;family burden;Feeling;Fright;Gender;girls;Goals;Guilt;Heterogeneity;high risk population;Immersion;improved;indexing;information processing;innovation;Intervention;Knowledge;Laboratories;Learning;Legal;Life;Measures;Mental disorders;Mental Health;Methods;Negative Valence;Occupational Health;Outcomes Research;Parasympathetic Nervous System;Pathway interactions;Patient Self-Report;Personality;physical conditioning;Physiological;Positive Valence;Prevention;psychopathic personality;Psychopathology;Psychophysiology;Punishment;Reporting;Research;respiratory;screening;sex;Sex Differences;Shapes;Sinus Arrhythmia;social;Societies;Stimulus;Subgroup;Symptoms;Technology;Temperament;Testing;theories;Time;Treatment Effectiveness;Treatment Efficacy;treatment response;treatment strategy;Violence;virtual reality;Youth

PROJECT_TITLE: Distinguishing Youth with Conduct Disorder with Callous-Unemotional Traits using Cardiovascular Psychophysiology During Virtual Reality Fear Induction: Testing for Sex Differences

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: DC

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: Nashville

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative The goal of this project is to develop patient-personalized cochlear implant stimulation models that could provide useful programming-assistance to clinicians and lead to better device settings. Thus, the methods developed in this project could potentially be used to improve hearing outcomes for new and existing cochlear implant recipients and improve the efficiency of the clinical programming process.

PI_NAMEs: NOBLE, JACK  (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TITLE: Model-based Cochlear Implant Programming

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ED_INST_TYPE: SCHOOLS OF EDUCATION

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Arctic;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: MISSOULA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: Project Narrative The proposed research reduces modifiable risk factors to prevent colorectal cancer among American Indian and Alaska Native (AIAN) older adults, who experience pronounced cancer health disparities (CHDs). Results contribute to a growing field of implementation science to address CHDs and follows landmark efforts to align with ethical, strengths-based practices for public health research with AIAN communities. At completion of the proposed aims, the trainee will transition into early-career investigator stage equipped with the expertise, experience, and networks to successfully launch an independent research career focusing on behavioral interventions to reduce CHDs among diverse, geriatric populations.

PI_NAMEs: PEDERSEN, MAJA  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acceleration;Address;Adult;Age;Aging;Alaska;Alaska Native;American Indians;Award;Behavior;behavior change;Behavior Therapy;Behavioral;Biometry;Cancer Control;cancer health disparity;cancer prevention;career;caucasian American;Collaborations;colon cancer risk;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Communities;community based participatory research;community organizations;community-level factor;Consensus;culturally appropriate intervention;Data;design;Dislocations;dissemination science;Educational workshop;effectiveness trial;Elderly;Ethics;Evidence based intervention;exercise intervention;experience;Experimental Designs;Fellowship;Geography;Goals;Health;high risk population;implementation science;implementation trial;improved;Inflammation;Intervention;Intervention Studies;Malignant Neoplasms;meetings;Mentors;Metabolism;Methods;modifiable risk;multidisciplinary;National Cancer Institute;Northern Plains;Obesity;older adult;Outcome;Pathway interactions;Phase;Physical activity;physical inactivity;Pilot Projects;Population;Postdoctoral Fellow;practice setting;pre-doctoral;Process;Public Health;Public Health Practice;public health priorities;public health research;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Reporting;Research;Research Personnel;resilience;Risk Factors;rural Americans;rural area;rurality;Scientist;skills;social;Training;Training Programs;Underserved Population;Voice;Waiting Lists;Walking

PROJECT_TITLE: Leveraging Implementation Science to Promote Behavior Change and Reduce Cancer Health Disparities among American Indian and Alaska Native Older Adults


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The studies proposed in this application will enhance our understanding of olfactory transduction, Ca2+- signaling, and GPCR signaling in general.

PI_NAMEs: YAU, KING-WAI  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Acetophenones;Address;Adenylate Cyclase;adenylyl cyclase III;Binding;Biochemical;Cations;Cellular biology;Chemoreceptors;Cilia;Complex;Confusion;Cyclic AMP;Cyclic GMP;Cyclic Nucleotides;density;examination questions;experimental study;Feedback;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;genetic manipulation;Golf;GTP-Binding Proteins;Hand;insight;Laboratories;Ligands;Light;mathematical model;Mediating;Membrane;Molecular;Molecular Biology;Multienzyme Complexes;Mus;Mutation;Nose;Odorant Receptors;Olfactory Epithelium;Olfactory Receptor Neurons;Pathway interactions;Performance;Phenethylamines;phosphoric diester hydrolase;Phototransduction;Probability;receptor;Retinal Cone;retinal rods;Rhodopsin;Rod;Sensory;Signal Transduction;success;Suction;Surface;Transducin;Uncertainty;Work

PROJECT_TITLE: Cyclic AMP- and Ca2+-Signaling in Sensory Transduction by Olfactory Receptor Neurons

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PHR: Project Narrative Children who are born preterm are at a high risk of development sensorimotor deficits, including developmental coordination disorder (DCD), one of the most common yet least studied developmental motor disorder. This study aims to investigate the predictive relationship between somatosensory processing deficits during early childhood in preterm children, and later motor development. Better understanding of the relationship between somatosensory deficits and motor development will allow us to identify children who experience these difficulties before they show significant motor delays and to develop tailored interventions for them.

PI_NAMEs: CHU, VIRGINIA WAY TONG (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: 1 year old;3 year old;3-Dimensional;5 year old;Activities of Daily Living;Adult;Affect;Age;Apraxia;autism spectrum disorder;Central Nervous System;Cerebral Palsy;Child;Child Behavior;Childhood;Clinical;design;Development;Developmental Coordination Disorders;developmental disease;Diagnosis;Down's Syndrome;early childhood;Early identification;effectiveness evaluation;Engineering;Esthesia;Evidence based intervention;experience;Feedback;Foundations;Future;grasp;high risk;innovation;instrument;interest;Intervention;Learning;Link;Maps;Measures;Methods;Motor;motor disorder;motor learning;Motor Skills;Movement;multisensory;Nervous System;neuromuscular;Outcome Measure;Parents;Perception;pilot test;Play;Population;Positioning Attribute;Primates;Production;programs;Proprioception;Reporting;Research;Role;Sensorimotor functions;Sensory;skill acquisition;skills;somatosensory;Standardization;stem;System;Tactile;Testing;therapy design;timeline;Touch sensation;Visual;Work;Writing

PROJECT_TITLE: Predictive ability of early somatosensory processing in preterm children on later motor development


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cervical Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Lung Cancer;Precision Medicine;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: PROJECT NARRATIVE Human papilloma virus (HPV) infection accounts for nearly all cervical and anal squamous cell carcinomas, a subset of other anogenital squamous carcinomas, and increasing rates of head and neck squamous cell carcinomas – all with relatively heterogenous clinical outcomes due to a lack of personalized care. Here, I propose a pan-cancer genomic analysis using extensive patient cohorts and targeted sequencing techniques to investigate the heterogeneity surrounding HPV-associated cervical, oral, and anogenital cancers as an ideal project to train as a future physician-scientist with an exceptional sponsor and complementary teams to support my research and clinical training. Through completion of this project, I will demonstrate that patients can be stratified in the clinic beyond anatomy and cytopathology, accommodate treatments to individuals, and work to improve patient outcomes through personalized medicine.

PI_NAMEs: HOLT, JEREMIAH R. (contact)

PROJECT_TERMS: Affect;Anatomy;Anogenital cancer;cancer classification;cancer genomics;Cancer Prognosis;cancer type;career;Cervical;Chromosomes;chronic infection;Classification;Clinic;Clinical;clinical training;clinically relevant;cohort;Cytopathology;Data;Development;Disease-Free Survival;DNA Sequence Alteration;DNA sequencing;driver mutation;Ensure;Environment;Epithelial Cells;Event;Exhibits;Future;Genes;Genome;genome-wide;genomic data;Genomic Instability;Genomics;Goals;Gynecologic;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Heterogeneity;HPV analysis;HPV negative;HPV positive;HPV-High Risk;Human;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Hybrids;improved;improved outcome;In Vitro;in vivo;Individual;individualized medicine;Life Cycle Stages;Link;Location;malignant mouth neoplasm;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Mediating;Mentors;Methodology;Modeling;Molecular;Molecular Abnormality;mouth squamous cell carcinoma;Mutation;neoplasm resource;next generation sequencing;novel;novel strategies;Oncogenic;Oncoproteins;Oral;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;personalized care;personalized medicine;Physicians;PI3K/AKT;PIK3CA gene;precision medicine;Prognosis;prognostic;Property;Proteins;Research Training;Residual state;Sample Size;Scientist;Smoking;Smoking Status;Somatic Mutation;Squamous cell carcinoma;Staging;Structure;targeted sequencing;Techniques;Testing;Therapeutic;TNM;TP53 gene;Training;training opportunity;Treatment outcome;tumor;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Variant;Viral;viral DNA;Viral Genome;Viral Load result;Virus Integration;Work

PROJECT_TITLE: Pan-cancer genomic characterization of human papillomavirus associated tumors


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative Aneuploidy is a cellular state in which cells contain extra or missing chromosomes. 90% of solid tumors are aneuploid, and aneuploidy has been shown to contribute to drug resistance, metastasis, and worse patient outcomes. The goal of this project is to use CRISPR screening to uncover aneuploidy-specific genetic dependencies that will serve as promising targets for therapeutic development.

PI_NAMEs: SCHUKKEN, KLASKE MARIJKE (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Affect;Aneuploid Cells;Aneuploidy;Apoptosis;Binding Proteins;Bioinformatics;Biological;cancer cell;Cancer cell line;cancer type;carcinogenesis;career;career development;Cell Aging;Cell division;cell growth;Cell Line;Cell Physiology;Cells;Cellular Stress;Chemoresistance;Chromosome 7;chromosome missegregation;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;colon cancer cell line;Colon Carcinoma;Communities;Complementary DNA;congenic;CRISPR library;CRISPR screen;Data;Defect;Dependence;design;Diploidy;Drug resistance;Drug Screening;Drug Targeting;Embryo;Environment;Epigenetic Process;Evolution;Exhibits;experimental study;Family;Fibroblasts;follow-up;Frequencies;Funding;Gene Dosage;gene function;Genes;Genetic;Genetic Screening;Glioblastoma;Goals;Growth;Human;Human Cell Line;inhibitor;insight;Karyotype;Knock-out;knockout gene;Knowledge;Libraries;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mass Spectrum Analysis;medical schools;Metabolic;Metabolic stress;Methodology;Molecular;Mus;Neoplasm Metastasis;Nocodazole;Pathway interactions;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Pituitary Gland Adenoma;Proteins;Proteomics;Research Personnel;Role;screening;secondary analysis;senescence;small molecule;small molecule inhibitor;Solid Neoplasm;Specificity;Stress;stressor;Survival Rate;targeted treatment;Techniques;Tertiary Protein Structure;therapeutic development;Toxic effect;Training;transcription factor;transcriptomics;tumor;ubiquitin ligase;Universities;Work

PROJECT_TITLE: Using CRISPR screening to uncover aneuploidy-specific genetic dependencies


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Hematology;Immunization;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases;Vaccine Related

ORG_CITY: STANFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative: Cancer is a leading cause of mortality and morbidity in the world. Among emerging immunotherapy technologies, vaccination strategies that both generate new antigen-specific T cell responses against tumor cells and amplify existing responses are particularly promising. We have now discovered just such a method called CART-RNA and through a unique collaboration between chemists, cancer immunologists, and biostatisticians we propose to advance this method and demonstrate its efficacy in the therapy of cancer in preclinical models with the clear goal of eventual application in the clinic.

PI_NAMEs: LEVY, RONALD ;WAYMOUTH, ROBERT M. (contact);WENDER, PAUL ANTHONY

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Address;Adoptive Cell Transfers;Amides;Amines;animal imaging;Animals;antigen-specific T cells;Antigens;Antitumor Response;Autologous;B-Lymphocytes;Biometry;Blocking Antibodies;cancer immunotherapy;cancer therapy;cancer vaccination;Cancer Vaccines;Catalysis;Cell Culture Techniques;cell type;Cells;Charge;Chemical Structure;Chemistry;chimeric antigen receptor;Clinic;Clinical Research;clinically relevant;Collaborations;combinatorial;Complex;Confocal Microscopy;Cryoelectron Microscopy;cytotoxicity;delivery vehicle;density;design;Development;disorder prevention;Drug Delivery Systems;effective therapy;Effectiveness;effectiveness evaluation;effector T cell;Electroporation;Engineering;Evaluation;Family;Formulation;Gene Expression;gene therapy;Genetic Engineering;Genetic Transcription;Goals;Human;Hybrids;Imaging Techniques;immune checkpoint blockade;Immune response;Immune system;Immunity;immunogenicity;Immunoglobulin Idiotypes;Immunologist;Immunology;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;interdisciplinary approach;Investigation;iterative design;Lactams;Length;lipid nanoparticle;Lipids;Lymphocyte;Lymphoma;Malignant Neoplasms;Mediating;Messenger RNA;Methods;Microbiology;Modeling;Molecular Biology;Molecular Immunology;Morbidity - disease rate;mortality;mouse model;mRNA delivery;mRNA Expression;mRNA immunotherapy;multidisciplinary;Mus;neoantigens;Neomycin resistance gene;neoplastic cell;Non-Viral Vector;novel;novel vaccines;Organ;patient population;Patients;Pharmaceutical Chemistry;pre-clinical;Pre-Clinical Model;Procedures;protein expression;Proteins;Research;response;RNA;RNA vaccination;Signal Pathway;Specificity;Structure;System;T cell response;T-Cell Lymphoma;T-Cell Receptor;T-Lymphocyte;Technology;Testing;Therapeutic;Tissues;Toxic effect;Transfection;Translations;tumor;Tumor-Infiltrating Lymphocytes;uptake;Vaccinated;Vaccination;vaccination strategy;Vaccine Therapy;Vaccines;Variant;vector;Viral Vector;zeta potential

PROJECT_TITLE: New Materials to Deliver mRNA: Applications in Cancer Immunotherapy

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;Hepatitis;Liver Disease;Microbiome;Neurosciences;Nutrition;Substance Misuse

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Heavy and chronic alcohol drinking is a major medical and public health problem that is frequently diagnosed as alcohol use disorder (AUD). Existing FDA approved treatment options for AUD have limited efficacy and adverse effects; thus, alcohol associated organ injury especially liver injury is a commonly observed comorbidity. This project may lead to the use of Lactobacillus rhamnosus GG (LGG) as a novel effective therapy for AUD and concomitant moderate alcohol associated hepatitis (AH).

PI_NAMEs: VATSALYA, VATSALYA  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Abstinence;Adverse effects;Adverse event;Albumins;Alcohol consumption;alcohol use disorder;Alcoholic beverage heavy drinker;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Animal Model;Animals;Award;Behavior Therapy;Behavioral;bench to bedside;Bilirubin;Biochemical Markers;Biochemistry;Biological Assay;Biological Markers;Blood;Brain;candidate marker;Chronic;chronic alcohol ingestion;Circulation;Clinical;Clinical Research;comorbidity;Complex;craving;Data;design;Diagnosis;Dietary Fiber;Disease;Disulfiram;Dopamine;Double-Blind Method;drinking;effective therapy;efficacy testing;efficacy validation;eligible participant;Endotoxemia;Enrollment;Equipment and supply inventories;experience;Faculty;FDA approved;Fermentation;Frequencies;Functional disorder;gamma-Aminobutyric Acid;Goals;Grant;gut microbiome;gut microbiota;gut-brain axis;Health;Healthcare;Heavy Drinking;Hepatitis;Human;improved;Inflammation;Inflammatory;Inflammatory Response;Intervention;Intestinal permeability;Knowledge;Lactobacillus casei rhamnosus;Lipopolysaccharides;Liver;liver development;Liver diseases;liver inflammation;liver injury;Measures;Mediating;Medical;men;Mentors;Mentorship;metabolomics;Methodology;microbiome alteration;Naltrexone;National Institute on Alcohol Abuse and Alcoholism;neurobehavioral;neuroinflammation;Neurotransmitters;new therapeutic target;novel;organ injury;Outcome;Pathway interactions;Patient Outcomes Assessments;Patients;Pharmaceutical Preparations;Pharmacological Treatment;Pilot Projects;Placebos;Positioning Attribute;preventable death;probiotic therapy;Probiotics;Prognostic Marker;programs;Property;Psychological reinforcement;Public Health;Publications;Quality of life;Randomized;Regulation;Relapse;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;restoration;Rewards;Role;Serotonin;Severities;skills;Structure;success;symptomatic improvement;Symptoms;tenure track;Testing;Therapeutic;therapeutic target;Training;treatment adherence;treatment comparison;treatment trial;Tryptophan;United States;Universities;Volatile Fatty Acids;Withdrawal;Woman;Work;Writing

PROJECT_TITLE: Lactobacillus rhamnosus: A Novel Probiotic Therapy for treating Alcohol Use Disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE: Worsening population-level trends in cardiometabolic health highlight the profound need to move away from traditional disease models focused on the remediation of downstream cardiometabolic risk factors to instead focus on relevant upstream exposures. A robust literature shows early life adversity exposures predict a host of cardiometabolic health outcomes, yet few studies have tested interventions designed to act on upstream adversity exposures to prevent cardiometabolic disease. The proposed study represents a unique and time sensitive opportunity to leverage an existing RCT in which a parenting intervention was implemented in a sample of low income, and postnatal women to determine whether benefits of the parenting intervention, originally designed to impact parent-child behavioral and relationship outcomes in infancy, may extend to the child’s cardiometabolic health in early childhood.

PI_NAMEs: BLEIL, MARIA E. (contact);SPIEKER, SUSAN JOAN

PROGRAM_OFFICER_NAME: REIS, JARED P

PROJECT_TERMS: Adjuvant;Adopted;Age;Area;Behavioral;Biological Markers;biological sex;Blood;Blood Pressure;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardiovascular health;Child;Child Rearing;Clinical;Collection;Data Sources;design;Disadvantaged;disease model;disorder risk;Distal;Dryness;early childhood;Early Intervention;early life adversity;Ethnic Population;evidence base;Exposure to;Family;Foundations;Funding;Goals;Health;Health behavior;health disparity;Home;Home visitation;improved;Individual;infancy;Infant;Inflammation;Informal Social Control;Intervention;intervention effect;Interviewer;Life;Life Cycle Stages;Literature;Low income;maternal depression;Maternal Health;Measures;Mediating;Mental Depression;Metabolic;Monitor;Mother-Child Relations;Mothers;National Institute of Child Health and Human Development;Outcome;parenting intervention;Parents;Patient Self-Report;physical conditioning;Polysomnography;Population;postnatal;prevent;Primary Care;programs;prospective;Questionnaires;racial minority population;Recording of previous events;remediation;resilience factor;Risk;Risk Factors;Sampling;Shapes;social health determinants;Socioeconomic Status;Spanish;Spottings;Testing;therapy design;Time;transmission process;Trauma;trend;United States National Institutes of Health;Visit;Woman;Work

PROJECT_TITLE: Does the provision of postnatal parenting support in primary care improve cardiometabolic health in early childhood among at-risk-families?

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Liver Disease;Pancreatic Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Pancreatic cancer shows remarkable resistance to T cell immunotherapy. This proposal will use mouse models of pancreatic cancer to study the role of toll-like receptor 2 in regulating T cell surveillance in cancer. Findings will improve our understanding of mechanisms that regulate the anti-tumor potential of T cells and may reveal novel therapeutic targets.

PI_NAMEs: PLESSET, JACQUELINE  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Affect;Amyloid;Apoptosis;Biology;Bone Marrow;Bone Marrow Cell Transplantation;Cancer Etiology;CD8-Positive T-Lymphocytes;Cell Death;Cell Physiology;cell type;Cells;Cessation of life;chimeric antigen receptor T cells;Communication;Complement;Cytometry;Data;Death Rate;design;Development;Disease;Educational process of instructing;effector T cell;Endothelial Cells;Environment;Epithelial Cells;Flow Cytometry;Genetic;Harvest;Hematopoietic;Hepatocyte;Immune;Immune Evasion;immune resistance;Immunologic Surveillance;Immunologics;immunoregulation;Immunotherapy;Implant;improved;ineffective therapies;Infiltration;Injections;Institution;intravenous injection;Knock-out;Knockout Mice;Knowledge;Kupffer Cells;Liver;liver function;liver inflammation;Malignant neoplasm of pancreas;Malignant Neoplasms;Mentors;Mentorship;Metastatic Neoplasm to the Liver;Monitor;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Nature;new therapeutic target;novel;novel strategies;Organ;Outcome;Pancreas;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathogenesis;Pathway interactions;Patients;Phenotype;Population;Productivity;Proteins;Publishing;receptor;reconstitution;Research;Resistance;Role;Serum;Serum amyloid A protein;Signal Pathway;Signal Transduction;Solid;Survival Rate;T cell infiltration;T cell regulation;T-Lymphocyte;Testing;Time;TLR2 gene;trafficking;Training;tumor;Tumor Biology;Tumor Burden;tumor immunology;Wild Type Mouse;Work

PROJECT_TITLE: A Role for TLR2 in Regulating Immune Surveillance in Pancreatic Ductal Adenocarcinoma


PHR: Project Narrative The vast majority of new cancer drugs fail to significantly help the patients who try them. We believe that this is in part because the targets of these drugs have not been determined correctly. We will use a set of genetic techniques to discover the real targets of several different cancer drugs, which may help clinicians identify which patients would be most likely to benefit from receiving them.

PI_NAMEs: SHELTZER, JASON  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Ablation;Alleles;anti-cancer research;Antineoplastic Agents;Biological Assay;Biological Markers;biomarker identification;cancer cell;cancer genetics;cancer therapy;Cell Cycle;Cell Cycle Progression;Cell Death Induction;cell killing;Cell Line;Cell Proliferation;Cells;cellular targeting;Chemicals;Clinical;clinical efficacy;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Coupled;CRISPR/Cas technology;Cyclin-Dependent Kinase Inhibitor;Dependence;Dose;Dose Limiting;Drug Design;drug isolation;drug repurposing;Drug resistance;Drug Targeting;Essential Genes;Evaluation;Exhibits;experimental study;Failure;fitness;Genes;Genetic;genetic architecture;Genetic Screening;Genetic Techniques;genetic technology;Goals;Growth;Human;In Vitro;in vivo;Induction of Apoptosis;inhibitor;knock-down;Knock-out;Knowledge;Laboratories;loss of function;Malignant - descriptor;Malignant Neoplasms;Mitotic;Mitotic Cell Cycle;Modeling;Mutagenesis;Mutation;novel;novel anticancer drug;novel therapeutics;null mutation;Oncology;patient population;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphotransferases;pre-clinical;Prediction of Response to Therapy;Proliferating;Proteins;Publishing;Reagent;Regimen;Reporting;Research;research clinical testing;Resistance;resistance mutation;response;RNA Interference;Role;Series;side effect;small molecule;small molecule inhibitor;Specificity;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissues;Toxic effect;tumor;tumorigenesis;Validation;Work

PROJECT_TITLE: Discovering the mechanisms of-action-mistargeted anti-cancer agents


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention

ORG_CITY: DAVIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE This study, focused on infants at elevated risk for autism spectrum disorder (ASD) and attention- deficit/hyperactivity disorder (ADHD), will identify early markers of self-regulation and social communication symptoms across early development with a focus on attention regulation, emotion regulation, and psychophysiological indicators. It will also enhance our understanding of relationships between self-regulation and social communication problems over time. The goal is that this research will improve early identification of disorders like ADHD and ASD, and encourage the development of process-focused interventions that can be applied across a range of infants and toddlers at risk.

PI_NAMEs: MILLER, MEGHAN RHYS (contact)

PROJECT_TERMS: Address;Affect;Age Months;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Award;Behavior;Behavioral;Child;cognitive control;cognitive system;Complex;design;Development;Diagnostic;diagnostic biomarker;Dimensions;Disease;Disease remission;early childhood;Early Diagnosis;Early identification;Early Intervention;emotion regulation;Exhibits;Genetic Risk;Goals;Heritability;high risk;Impairment;improved;indexing;Individual;Infant;Informal Social Control;informant;Intervention;Investigation;Link;Measures;Mediating;Mental disorders;Methods;National Institute of Mental Health;Nervous System Physiology;novel marker;Nursery Schools;Outcome;Parasympathetic Nervous System;Pathway interactions;Pattern;Phenotype;Physiological;Prevention;Process;Psychophysiology;Regulation;Research;Research Domain Criteria;respiratory;Risk;Sampling;Sinus Arrhythmia;social communication;Social Processes;Strategic Planning;Symptoms;Time;Toddler;trait;Treatment Efficacy;United States National Institutes of Health;Visit

PROJECT_TITLE: An investigation of transdiagnostic mechanisms underlying ASD and ADHD traits among infants at risk


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CINCINNATI

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative: Up to 5.3 million people in the U.S. live with long-term disabilities after traumatic brain injury (TBI), and patients with moderate and severe TBI have the highest acute, subacute, and long-term need for resources. Untrained friends and family members often assume caregiving responsibilities; however, few are prepared to do so, and caregivers subsequently experience problems with depression, health, and poor life changes as a result of caregiving. The goal of this study is to determine if early involvement of the caregiver acutely after adult TBI with a novel online intervention, CG-Well, is feasible, acceptable, and associated with improved caregiver wellbeing compared to a control group.

PI_NAMEs: KREITZER, NATALIE  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Active Learning;Active Listening;Acute;Address;Adult;Affect;Award;biopsychosocial;career;caregiver education;caregiver interventions;Caregiver well-being;Caregivers;caregiving;Caring;Characteristics;Chronic;Climacteric;cohort;comparison control;Complex;Consensus;contextual factors;Control Groups;coping;Coupled;Data;depressive symptoms;disability;Distal;Education;Educational workshop;efficacy testing;Enrollment;experience;Face;Family;Family Caregiver;Family member;feasibility testing;Feedback;follow-up;Foundations;Friends;Future;Goals;Health;health related quality of life;improved;improved outcome;Injury;innovation;Intensive Care Units;Intervention;Knowledge;Long term disability;Measures;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modeling;Nervous System Disorder;Nervous System Trauma;novel;Nurses;online intervention;Outcome;Parents;Patients;pediatric traumatic brain injury;Personal Satisfaction;Persons;Phase III Clinical Trials;phase III trial;Positioning Attribute;Preparation;primary outcome;Problem Solving;Provider;Psychologist;psychosocial;Psychosocial Factor;Publishing;Randomized;Randomized, Controlled Trials;Recording of previous events;Recovery;recruit;Reporting;Research;Research Personnel;Resources;response;Risk Factors;Role;satisfaction;Severities;skills;Social Distance;Social Workers;Spouses;Survivors;symposium;Systems Theory;TBI Patients;Telephone;Testing;therapy design;Time;timeline;Training;Training Activity;Transportation;Traumatic Brain Injury;trend;Universities;usability;Work

PROJECT_TITLE: Caregiver Wellness after Traumatic Brain Injury (CG-WELL): An Intervention Designed to Promote Well-being in Caregivers of Acute Moderate to Severe Traumatic Brain Injuries

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Pulmonary fibrosis is thought to be driven by epithelial injury and self-sustaining pathological feedback loops. However, there is abundant evidence that the lung can resolve fibrosis during successful tissue repair, though the cellular mechanisms and molecular mediators are not well understood. This project will study whether epithelial dopamine synthesis is an essential trigger of fibrosis resolution, and whether dopaminergic signaling can be harnessed in experimental lung fibrosis and human fibrotic lung tissue to promote lung repair.

PI_NAMEs: TSCHUMPERLIN, DANIEL J. (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Ablation;Acceleration;Age;Aging;Biochemical;Biological Availability;Biomechanics;Bleomycin;cell type;Cells;Chronic;Collagen;Data;Deposition;Depressed mood;Disease;Dissociation;DOPA decarboxylase;Dopamine;Dopamine Agonists;Dopamine D1 Receptor;Dopamine Receptor;Enzymes;Epithelial Cells;epithelial injury;epithelial repair;Epithelium;Exhibits;Experimental Models;Extracellular Matrix;Feedback;Fibroblasts;Fibrosis;fibrotic lung;Funding;Genetic Models;Homeostasis;Human;Impairment;Individual;inhibitor;Injury;Ligands;Lung;lung injury;lung repair;Mediator;Medical;Mesenchymal;Modeling;Molecular;mouse model;Mus;novel therapeutic intervention;old mice;Pathologic;pharmacologic;Production;Profibrotic signal;Publishing;Pulmonary Fibrosis;Regulation;repaired;Resolution;response;restoration;Role;Signal Transduction;single cell analysis;single-cell RNA sequencing;Slice;small molecule;small molecule inhibitor;Source;Structure of parenchyma of lung;System;Testing;Therapeutic;tissue repair;Transcript;Work

PROJECT_TITLE: Epithelial-Mesenchymal Interactions in Fibrosis Resolution

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The five year survival rate of ovarian cancer patients has remained at 47% for decades, highlighting the urgent need for therapeutic strategies that activate potent anti-tumor immune responses. One such strategy is epigenetic therapy, which stimulates an immunogenic response in cancer cells by inducing the transcription of repetitive elements (REs)—genomic regions that are normally silent. The goal of this project is to investigate REs as an inducible source of tumor-associated antigens that can be directly targeted by RE-specific T cells in combination with epigenetic therapy, resulting in an increased anti-tumor immune response and potentially curative immune therapy for ovarian cancer patients.

PI_NAMEs: GRUNDY, ERIN ELIZABETH (contact)

PROJECT_TERMS: anti-tumor immune response;Antigen Presentation Pathway;Antigen Targeting;Antigens;Bioinformatics;bioinformatics tool;Biological Assay;Blood donor;cancer cell;Cancer cell line;Cancer Model;Cancer Patient;career;Cell Differentiation process;cell killing;Cells;chemotherapy;clinically relevant;Coculture Techniques;Color;Competence;Critical Thinking;curative treatments;cytotoxicity;Data;Development;Elements;Endogenous Retroviruses;Epigenetic Process;epigenetic therapy;Epitopes;Excision;experience;Experimental Designs;experimental study;Flow Cytometry;Genes;Genetic Materials;Genetic Transcription;Genomic Segment;Genomics;Goals;Histocompatibility Antigens Class I;HLA Antigens;Human;Immune;Immune response;Immune system;immunodeficient mouse model;immunogenic;immunogenicity;Immunologics;Immunophenotyping;Immunosuppression;Immunotherapy;In Vitro;in vivo;Innate Immune Response;innovation;Interferon Type II;Interferons;Knowledge;Laboratories;Lytic;Malignant - descriptor;Malignant neoplasm of ovary;Mentors;mimicry;mouse model;neoplastic cell;Normal tissue morphology;novel;novel therapeutic intervention;Operative Surgical Procedures;ovarian neoplasm;Patients;Peptide Library;Peptides;Positioning Attribute;Postdoctoral Fellow;prediction algorithm;Predisposition;Process;protein aminoacid sequence;Proteins;Protocols documentation;Publishing;Recurrent disease;Repetitive Sequence;Research;response;RNA;Role;Running;Sampling;Scientist;skills;Solid Neoplasm;Source;Specificity;success;Surface;Survival Rate;T cell therapy;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Transcript;transcriptome sequencing;treatment strategy;tumor;Tumor Antigens;tumor immunology;tumor microenvironment;tumor-immune system interactions;Up-Regulation;Viral;viral RNA;Virus;Whole Blood

PROJECT_TITLE: Combining repetitive element-specific T cells with epigenetic therapy to treat ovarian cancer


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE The pathogen Mycobacterium tuberculosis (M.tb) causes pulmonary tuberculosis (TB) in millions of humans each year, and the global disease burden has stagnated because we have a small vaccine pipeline. Here, we develop, test, and optimize novel prime/boost heterologous protein/RNA vaccines against TB in advanced preclinical animal models. The vaccines we identify will provide candidates for clinical trials by better predicting efficacy across genetically diverse experimental animal models.

PI_NAMEs: BEAMER, GILLIAN L (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Address;Adjuvant;Aliquot;aluminum sulfate;Animal Model;Animals;Antigens;Bacille Calmette-Guerin vaccination;BCG Live;Binding;Biological Assay;Biological Response Modifiers;Blood;burden of illness;candidate identification;candidate selection;Cavia;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Cellular Assay;Cellular Immunity;clinical candidate;Clinical Trials;combat;Communicable Diseases;Databases;design;Development;Disease;disease transmission;efficacy testing;Emulsions;Ensure;Epidemiology;Equilibrium;Euthanasia;Experimental Animal Model;Failure;Formulation;Future;Genes;Genetic Variation;Genotype;Goals;Human;Humoral Immunities;IL17 gene;Immune;Immunity;Immunize;immunogenic;immunogenicity;Immunoglobulin A;Immunoglobulin G;Inbred Mouse;Inbred Strain;Infection;Inflammatory Response;innovation;insight;Interferon Type II;Intramuscular;lead candidate;Ligands;Liposomes;Lung;Measurable;Measures;Mediating;Mind;Modality;Modeling;Modern 1601-history;Morbidity - disease rate;Mucosal Immune Responses;Mucosal Immunity;Mucous Membrane;Mus;Mycobacterium bovis;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;nano;Newly Diagnosed;next generation;novel;novel vaccines;Outcome;pathogen;Patients;Persons;Phase;Phenotype;Population;pre-clinical;pre-clinical assessment;Pre-Clinical Model;Predisposition;Proteins;Pulmonary Tuberculosis;Reproducibility;Reproduction;response;RNA;RNA amplification;RNA vaccine;Rodent Model;Route;Sampling Studies;screening;Serum;Spleen;Squalene;statistics;success;T cell response;T-Lymphocyte;Testing;thermostability;Tissue Sample;Tissues;transmission process;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;Vaccinated;Vaccination;vaccine candidate;vaccine development;vaccine discovery;vaccine platform;vaccine trial;Vaccines;Work;World Health Organization

PROJECT_TITLE: Advancing Innovative Next_generation Heterologous Vaccines Against Tuberculosis


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: RELEVANCE TO PUBLIC HEALTH  The goal of this project is to develop and evaluate next generation MRI technologies on an FDA approved ultrahigh field (UHF) MRI system (Siemens 7T Terra) that allow in vivo quantitative imaging of microvascular blood flow across the cortical layers and columns in a live human brain. This new technology will greatly improve our capabilities for understanding brain function at the level of circuits and their aberrations in brain disorders.

PI_NAMEs: WANG, DANNY JJ (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Adoption;Affect;Algorithms;Anatomy;Animals;arterial spin labeling;Blood capillaries;Blood flow;blood flow measurement;blood oxygen level dependent;Blood Vessels;Brain;Brain Diseases;brain tissue;cerebral blood volume;Cerebral cortex;Cerebrovascular Circulation;Clinical;Communities;Complex;Data;denoising;FDA approved;Functional Magnetic Resonance Imaging;Goals;health goals;Human;Image;imaging modality;Imaging technology;improved;in vivo;innovation;invention;Label;magnetic field;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Measures;Metabolic;metabolic imaging;Metabolism;Methods;millimeter;MRI Scans;neural;neurovascular;new technology;next generation;Noise;non-invasive imaging;novel;Oxygen;Pattern;Perfusion;perfusion imaging;Physiologic pulse;Physiology;Pial Veins;Predisposition;Public Health;quantitative imaging;reconstruction;Research;Resolution;response;Rest;Scheme;Short-Term Memory;Signal Transduction;Site;Specimen;Spin Labels;Surface;System;Techniques;Technology;temporal measurement;Time;Tissues;Variant;virtual;Water

PROJECT_TITLE: Laminar Perfusion Imaging

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lung;Lung Cancer;Precision Medicine;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE The current management of indeterminate pulmonary nodules (IPNs) is associated with high rates of invasive and costly procedures. We propose, for the first time in an investigator-initiated study, to prospectively test the clinical utility of a biomarker-enhanced approach for the management of IPNs in a randomized clinical trial with the goal of reducing the number of invasive procedures and time to diagnosis.

PI_NAMEs: BARON, ANNA E;GROGAN, ERIC L (contact)

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: Academic Medical Centers;Address;Adoption;Anxiety;arm;Benign;Biological Assay;Biological Markers;biomarker driven;biomarker performance;biomarker signature;biomarker validation;Biopsy;Blinded;Blood;Bronchoscopy;cancer risk;candidate marker;chest computed tomography;Classification;Clinical;Clinical Management;clinical research site;clinical risk;Clinical Trials;clinically relevant;cohort;Colorado;cost;cost effective;Data;Deoxyglucose;design;Diagnosis;diagnostic accuracy;Disease;Enrollment;Evaluation;falls;Fine needle aspiration biopsy;Future;Goals;high risk;Image;improved;Individual;Institution;interest;Interferometry;Laboratories;lung cancer screening;Lung nodule;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Modeling;Morbidity - disease rate;Multicenter Trials;Nodule;noninvasive diagnosis;operation;Operative Surgical Procedures;Outcome;Participant;patient population;Patients;Positron-Emission Tomography;predictive modeling;primary endpoint;Probability;procedure cost;Procedures;prospective;prospective test;Provider;quantitative imaging;radiomics;Randomized;randomized trial;randomized, clinical trials;rapid testing;Readiness;Research Personnel;Risk;Risk Factors;risk prediction;risk stratification;sample collection;Sampling;Scheme;Serum;Serum Proteins;Specimen;standard of care;Stratification;Target Populations;Testing;Time;Training;treatment arm;Universities;Validation;Work;X-Ray Computed Tomography

PROJECT_TITLE: Clinical Utility of Biomarkers Driven Management of Indeterminate Pulmonary Nodules

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Although the unique regenerative potential of the oral mucosa has long been recognized and appreciated, the mechanisms that facilitate rapid wound closure, limited inflammatory response and the non-scarring phenotype of the oral cavity are unknown. This proposal will build off our lab’s preliminary characterization of the oral epithelial progenitor cell (OEPC) population to dissect how low and high inflammatory conditions can alter OEPC response to injury and the ability of the oral mucosa to heal. This work acts as a necessary first step in understanding the superior regenerative capacity of the oral mucosa and the regulatory ability of inflammation, which will aid in our understanding of chronic inflammatory diseases in the oral cavity and facilitate the development of therapies that harness the innate mechanisms of the oral mucosa to improve or stimulate wound healing.

PI_NAMEs: COOK, JESSICA  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acceleration;Achievement;Address;Adult;Animals;Apoptosis;assault;Atrophic;Attenuated;Bone necrosis;California;career;cell behavior;cell motility;Cells;cellular targeting;Chemicals;Chronic;chronic inflammatory disease;chronic wound;Clinical;clinical training;Coculture Techniques;craniofacial;Data;Data Set;daughter cell;Dental Schools;Dentists;Depressed mood;Dermal;design;Disease;Environment;Epithelial Cell Proliferation;Epithelial Cells;epithelial stem cell;Epithelium;Equilibrium;Event;Exposure to;Fluorouracil;Goals;Group Meetings;Hair follicle structure;Hair Removal;healing;Healthcare;Hematoxylin and Eosin Staining Method;Hemostatic function;Histologic;Homeostasis;Image;Immune;Immune response;Immune system;improved;In Vitro;Individual;Infection;infection risk;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune System;insight;Jaw;Journals;keratinocyte;Mediating;Mentorship;migration;Modeling;Molecular;mouse model;Natural regeneration;nutrition;open wound;Oral;Oral cavity;oral cavity epithelium;Oral Characters;Oral health;oral mucositis;Oral mucous membrane structure;Pathology;Pathway interactions;Patients;Periodontitis;Phase;Phenotype;programs;Proliferating;Qualifying;re-epithelialization;Reaction;regeneration potential;regenerative;Regenerative capacity;Regulation;repaired;Repression;Research;response;response to injury;Role;San Francisco;Scientist;Signal Transduction;single-cell RNA sequencing;Site;Skin;skin wound;stem cell fate;stem cell population;stem cell proliferation;stem cells;Stratum Basale;Structure;System;Testing;Therapeutic;therapy development;Time;Tissue Stains;Tissue-Specific Gene Expression;Tissues;Training;Universities;Work;wound;wound bed;wound closure;wound healing;wound response

PROJECT_TITLE: Deciphering Inflammatory Regulation of Oral Epithelial Progenitor Cells During Oral Mucosal Regeneration


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE  Acute myeloid leukemia (AML), one of the most common and fatal forms of hematopoietic malignancies, is a stem cell disease caused by gene mutations and genomic rearrangements. Here, we will investigate the novel role of YTHDC1 in the development and maintenance of AML and elucidate the mechanisms underlying the role of YTHDC1. This study will advance our knowledge and understanding of molecular basis of AML, potentially leading to the identification of a new effective treatment for AML patients.

PI_NAMEs: QIAN, ZHIJIAN  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: 3-Dimensional;Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Binding;Biological Process;cancer type;Cell Proliferation;Cells;chromatin assembly factor I;Communities;Complex;crosslinking and immunoprecipitation sequencing;Deposition;Development;Disease;DNA biosynthesis;DNA Repair;DNA Sequence Rearrangement;effective therapy;Epigenetic Process;epitranscriptome;epitranscriptomics;Excision;Gene Expression Regulation;Gene Mutation;Genes;Genetic;Genomic approach;Hematology;Hematopoiesis;Hematopoietic Neoplasms;Hematopoietic stem cells;Human;improved;In Vitro;in vivo;insight;Knowledge;leukemia;leukemia treatment;leukemic stem cell;leukemogenesis;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;Mediator;Messenger RNA;Methylation;Methyltransferase;MLL-AF9;Modeling;Modification;Molecular;mouse model;Mus;mutant;new therapeutic target;novel;Nuclear;Nuclear Decay;Nuclear Export;Nuclear RNA;overexpression;Pathogenesis;Pathway interactions;Patients;Play;Polyadenylation;Polyribosomes;Post-Transcriptional Regulation;posttranscriptional;Process;Protein Family;Reader;Regulation;Reporting;Ribosomes;RNA;RNA methylation;RNA Splicing;Role;self-renewal;Site;stem;stem cell self renewal;stem cells;success;targeted treatment;Therapeutic;transcriptome;transcriptome sequencing;treatment strategy;tumorigenesis;Up-Regulation;Xenograft Model

PROJECT_TITLE: The role of YTHDC1 in normal and malignant hematopoiesis

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Pediatric;Prevention

ORG_CITY: NOTRE DAME

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE Emotion dysregulation is a transdiagnostic risk factor for psychopathology, and as such, the elucidation of specific longitudinal pathways by which children develop emotion regulation or dysregulation is critical. This research will (1) determine which aspects of maternal emotion regulation are most relevant for maternal emotion-related socialization behaviors over time, and (2) evaluate the influence of maternal emotion regulation on child emotion regulation over time, and the extent to which maternal emotion-related socialization behaviors mediate that association. Accordingly, this research will inform public health efforts to improve children’s emotion regulation and psychological functioning by identifying processes (i.e., maternal emotion regulation, emotion-related socialization behaviors) that may be targets for translational programs aimed to improve children’s ER and reduce risk for psychopathology.

PI_NAMEs: EDLER, KATHERINE A (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 8 year old;Adult;Affect;Age;Behavior;Behavioral;Biological Markers;Biological Process;Caregivers;caregiving;Child;Child Development;Childhood;Cognitive;cognitive reappraisal;coping;design;Development;Diagnostic;Effectiveness;emotion dysregulation;emotion regulation;Emotional;emotional experience;Emotions;Environment;Evaluation;Family;Fellowship;Fostering;Frustration;Future;Goals;Heart;improved;insight;Intervention;intervention program;Knowledge;Life;longitudinal analysis;Low income;low socioeconomic status;Measures;Mediating;Mediation;Methodology;Methods;middle childhood;Modeling;Monitor;Mothers;negative affect;Outcome;parental influence;Parents;Pathway interactions;Patient Self-Report;Pattern;peer;Physiological Processes;Policies;Prevention program;Process;programs;psychobiologic;psychologic;Psychopathology;Public Health;Questionnaires;Reaction;Reporting;Research;Research Ethics;Research Methodology;respiratory;Rest;Risk;Risk Factors;Risk Reduction;Role;Sampling;Shapes;showing emotion;Sinus Arrhythmia;skills;social skills;Socialization;socialization behavior;success;Time;Training;Universities;Visit

PROJECT_TITLE: Longitudinal associations between maternal and child emotion regulation: Examining the role of maternal emotion-related socialization behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: In ALS, damaged proteins are not properly eliminated, leading to their accumulation and this compromises cell health. Work in genetically tractable organisms and tissue culture show that loss of a protein called RAD23 promotes the degradation of damaged proteins and in this proposal we ask if these findings can be extended to mouse models of ALS.

PI_NAMEs: KALB, ROBERT G (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Ablation;Acceleration;ALS patients;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotides;Autophagocytosis;Behavior;Biochemical;Biochemistry;Biological Models;Caenorhabditis elegans;Cell Physiology;Cells;Clinical;Degradation Pathway;Disease;Disease Progression;Equilibrium;experimental study;Genes;Genetic;Goals;Health;Health Promotion;Histology;Image;improved;In Vitro;inhibitor;innovation;knock-down;Mammals;Mediating;MG132;misfolded protein;Modeling;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Mutate;Nematoda;Neurodegenerative Disorders;operation;Organism;Pathway interactions;Phenotype;Play;polyglutamine;Process;Proteasome Inhibition;protein aggregation;Protein Biosynthesis;protein degradation;Protein Isoforms;protein TDP-43;Proteins;proteostasis;proteostasis loss;RAD23B gene;Role;System;Technology;Testing;Therapeutic;tissue culture;Transgenic Mice;Translating;translational potential;Ubiquitin;ultraviolet irradiation;Work;Yeasts

PROJECT_TITLE: RAD23 Control of ALS phenotypes

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Lung;Neonatal Respiratory Distress;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Pulmonary Hypertension;Rare Diseases

ORG_CITY: FORT WORTH

ORG_NAME: AYUVIS RESEARCH, INC.

ORG_STATE: TX

PHR: NARRATIVE Bronchopulmunary Dysplasia (BPD) is a disease of pre-term infants whose lungs are injured upon exposure to excess oxygen from ventilators, impairing effective gas exchange in the lungs. Ayuvis Research is developing a novel class of immunomodulating compounds derived from chitin that decrease inflammation, improve lung vascularization, decrease pulmonary hypertension and altogether prevent the depelopment of BPD in preclinical large animal model. Our objective in this proposed grant application is to test the safety and pharmacokinetic profile of our lead compound in a Phase I SAD/MAD Clinical Trial in healty human volunteers, which is a key stage in the development of our much needed prophylactic treatment for BPD in infants and treatment for other life-threatening lung conditions.

PI_NAMEs: ACHARYA, SUCHISMITA  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Adolescent;Adrenal Cortex Hormones;Adult;Affect;Alveolar;Angiogenic Factor;Animal Model;antenatal;Anti-Inflammatory Agents;Applications Grants;Bacteremia;Binding;Biological Markers;Blood specimen;Bolus Infusion;Bronchopulmonary Dysplasia;Canis familiaris;Cardiotoxicity;Cell Death;Cells;Cessation of life;Childhood;Chitin;chronic respiratory disease;Clinical;Clinical Protocols;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;comorbidity;Complication;Consent Forms;Contracts;Data;Data Reporting;design;Development;Diagnosis;Disease;Dose;drug development;Drug Kinetics;Dysplasia;early childhood;efficacy evaluation;Endothelial Growth Factors;Ensure;Exposure to;first-in-human;Formulation;Freezing;Future;Gases;Genetic Predisposition to Disease;genotoxicity;Gestational Age;Goals;Gram-Negative Bacterial Infections;Human Volunteers;Hyperoxia;Immunologist;immunoregulation;Impairment;improved;In Vitro;Incidence;Infant;Infection;Inflammation;Inflammation Mediators;Injections;Interleukin-10;Intervention;Intraperitoneal Injections;Intravenous;intravenous administration;intravenous injection;Label;Lead;lead candidate;Life;Lung;lung injury;Macrophage;Manuals;manufacture;manufacturing test;Marketing;Maximum Tolerated Dose;Mechanical ventilation;Mechanical Ventilators;Modeling;Molecular Weight;Monitor;mouse model;Mus;Neonatal;neonatal mice;neonate;No-Observed-Adverse-Effect Level;novel;novel therapeutics;Oligosaccharides;operation;Orphan Drugs;Oxygen;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Phase;Phase I Clinical Trials;Phase II Clinical Trials;Phenotype;Powder dose form;pre-clinical;pre-Investigational New Drug meeting;Premature Birth;Premature Infant;prenatal;Preparation;preterm newborn;prevent;Procedures;product development;Production;programs;Prophylactic treatment;Protocols documentation;pulmonary function;Pulmonary Hypertension;Pulmonary Inflammation;pup;Qualifying;Rattus;Recommendation;recruit;Reporting;Research;Research Personnel;respiratory;Respiratory Disease;Risk;Safety;safety testing;Saline;Sampling;Scientist;Seasons;Secondary to;Serum;Signal Transduction;Site;small molecule;stability testing;Sterility;surfactant;Techniques;Therapeutic Effect;Therapeutic Index;Time;timeline;TLR4 gene;Transforming Growth Factor beta;Up-Regulation;Vascular Endothelial Growth Factors;Vascularization;ventilation;Ventilator;Vial device;volunteer;Writing

PROJECT_TITLE: Phase-1 Healthy adult human safety and pharmacokinetic study of AVR-48, a small molecule macrophage modulator to prevent bronchopulmonary dysplasia in at-risk pre-term infants


PHR: PROJECT NARRATIVE Epilepsy is a chronic, debilitating neurological condition that affects 50 million people worldwide. Although it often runs in families, the genetic causes of familial epilepsy are not well understood. This research will help us understand the genetic causes of familial epilepsy, identify biological mechanisms that could be potential treatment targets, and develop new tools that use genetic information to improve the diagnosis and treatment of people with epilepsy.

PI_NAMEs: ELLIS, COLIN  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Affect;analytical method;analytical tool;Area;Bioinformatics;Biological;Caring;case control;childhood epilepsy;Chronic;Clinic;Clinical;clinical application;clinical development;clinical diagnosis;Clinical Treatment;Clinical Trials Design;cohort;Complex;Data;Data Set;Dedications;design;Diagnosis;Disease;Distant;epidemiology study;Epilepsy;Epileptogenesis;experience;experimental study;Familial disease;Family;family structure;Future;gene discovery;Gene Mutation;Gene set enrichment analysis;Genes;Genetic;genetic information;Genetic Materials;Genetic Research;Genetic Risk;genetic variant;Genome;genome-wide;genomic data;Genomics;Genotype;Goals;Hereditary Disease;Heritability;heritability pattern;improved;Individual;individual patient;Inherited;innovation;insight;International;K-Series Research Career Programs;life span;Mentors;Mentorship;Methodology;Methods;Modeling;Molecular Genetics;Mutation;neurogenetics;Neurologic;Neurology;novel;offspring;Other Genetics;Parents;Pathway interactions;Patient Care;Patients;Pennsylvania;Persons;Phenotype;Physicians;polygenic risk score;Population;Population Control;Positioning Attribute;professor;Records;recruit;Research;Research Methodology;Risk;Risk Assessment;risk variant;Running;Scientist;skill acquisition;skills;Statistical Models;success;Testing;time use;tool;Training;trait;Translating;transmission process;Universities;Variant;whole genome

PROJECT_TITLE: Polygenic risk in familial epilepsy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: CORIDEA, LLC

ORG_STATE: NY

PHR: Public Health Relevance Obstructive hypertrophic cardiomyopathy is a common cardiac disorder that in some people can lead to substantial limitations in acts of daily living, poor prognosis, and mortality. Gold standard therapy for patients who do not respond to medical management are invasive septal reduction surgeries that have a high rate of serious side-effects and mortality. This proposal will validate a new minimally invasive method to precisely treat the source of the obstruction in a procedure that we believe will be safer and better suited for many patients than the currently available treatments.

PI_NAMEs: LEVIN, HOWARD  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Ablation;Acceleration;Acoustics;Acute;Adverse effects;Alcohols;Anatomy;animal data;Animal Model;Animals;atrioventricular node;behavior observation;Brain;Cardiac conduction system;Cardiac Electrophysiologic Techniques;cardiac magnetic resonance imaging;Catheters;Certification;Characteristics;Chest Pain;Chronic;Clinical;Clinical Pathology;Clinical Trials;commercialization;comorbidity;Coronary artery;Critical Illness;Dangerousness;Data;Defibrillators;design;design verification;Development;Devices;Disease;dosimetry;Dyspnea;Elements;Endothelium;Equilibrium;Equipment;Femur;Frequencies;Future;Gel;Geometry;Grant;healing;Health;Heart Block;Heart Diseases;heart rhythm;Histopathology;Human;Hypertrophic Cardiomyopathy;Hypertrophy;implantation;improved;Industry Standard;Inflammation;Inherited;Injury;International;Irrigation;Laboratories;Left;Lesion;Life;Lung;manufacturability;manufacture;Medical;meetings;Methods;minimally invasive;Modality;mortality;Nature;novel;Obstruction;Operative Surgical Procedures;Organ;Output;Pacemakers;Pathology;patient subsets;Patients;Performance;Persons;Phase;Physics;pre-clinical;Pre-Clinical Model;Preparation;preservation;Procedures;Process;Prognosis;prototype;public health relevance;Radiation;Refractory;Reporting;research clinical testing;Resistance;Resolution;response;Right ventricular structure;Risk;Risk Reduction;Safety;side effect;Small Business Innovation Research Grant;Source;Sterility;System;Techniques;Technology;Testing;Therapeutic;Thick;Thinness;Thrombus;Tissues;tool;Transducers;Ultrasonic Transducer;ultrasound;ultrasound ablation;Venous;Ventricular;Ventricular septum;verification and validation;Work

PROJECT_TITLE: Minimally Invasive High Intensity Therapeutic Ultrasound for the Treatment of Obstructive Hypertrophic Cardiomyopathy


NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative The proposed research is relevant to public health and aims at understanding how coordinated approaches can be used to rapidly guide microvascular development. This will enable new and translatable reconstructive approaches for tissue loss, and broadly advance regenerative medicine.

PI_NAMEs: RAVNIC, DINO J;SHEIKHI, AMIR  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TITLE: Manipulation of Host Tissue to Induce a Hierarchical Microvasculature

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The year after birth, also known as the “fourth trimester”, is a growing focus of efforts to address high rates of maternal morbidity and mortality in the United States, which disproportionally affect racial-ethnic minorities, rural women and Medicaid beneficiaries. Yet, high-quality evidence on postpartum health and wellbeing and the drivers of postpartum health disparities is severely lacking. This project will address this important gap by collecting and analyzing rich multi-state survey data on the health and social needs of postpartum women in the year after birth, producing data of high scientific value with the aim to identify mechanisms that could be targeted to reduce postpartum health disparities.

PI_NAMEs: ALLEN, HEIDI LYNN;DAW, JAMIE ROBERTA (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Affect;beneficiary;Birth;Birth Certificates;Black race;black women;Centers for Disease Control and Prevention (U.S.);Characteristics;City Government;clinical risk;cohort;Collaborations;Collection;Conceptions;COVID-19;COVID-19 pandemic;Data;Data Collection;Dimensions;Discrimination;Disparity;economic determinant;economic disparity;Economic Factors;Economics;ethnic minority;Ethnic Origin;evidence base;experience;Fatigue;feeding;follow-up;fourth trimester;Funding;Geography;Goals;Grant;Health;health care disparity;health data;health determinants;health disparity;health equity;health outcome disparity;Health Policy;Healthcare;Height;Hispanic Women;Housing;improved;Indigenous;Individual;Infant Care;Infection;Insurance;Insurance Coverage;Intervention;Investments;Left;Link;long-standing disparities;longitudinal dataset;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;Measures;Medicaid;Mental Depression;Mental Health;Methods;Modeling;Monitor;Morbidity - disease rate;multidisciplinary;neglect;New York City;novel;Outcome;Pain;pandemic disease;Participant;Personal Satisfaction;physical conditioning;Physical environment;Policies;Policy Maker;Policy Making;Population;population based;post-pandemic;postpartum care;Postpartum Depression;postpartum health;postpartum morbidity;Postpartum Period;Postpartum Women;Pregnancy;pregnancy related death;Pregnant Women;prenatal;Privatization;programs;Public Health;public health emergency;Quality of life;Race;racial minority;Recovery;Regulation;Research;Research Personnel;Resources;Risk Assessment;Risk Factors;Role;Rural;rural dwellers;rural residence;severe maternal morbidity;Sexuality;Sleep;social;social determinants;social disparities;Social Environment;social factors;Social Policies;sociodemographics;Source;State Government;Statutes and Laws;Subgroup;substance use;Surveys;System;United States;Woman;Work

PROJECT_TITLE: The Postpartum Assessment of Women Survey (PAWS): Informing Medicaid Policies to Improve Health in the "Fourth Trimester"

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: LEGON

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: UNIVERSITY OF GHANA

PHR: PROJECT NARRATIVE The objective of the proposed training program is to increase research into the detection, prevention and treatment of drug-resistant infections in West Africa, and expand knowledge and skills in clinical microbiology. The program involves providing a rigorous PhD student training, and offering tailored training to junior scientists and faculty from West Africa, in antimicrobial resistance. The major outcome will be a significant increase in antimicrobial resistance research capacity in the West African sub-region.

PI_NAMEs: SAMPANE-DONKOR, ERIC  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Academic Training;Achievement;Acute;Address;Affect;Africa;Africa South of the Sahara;African;Age;Antimicrobial Resistance;Area;Bioinformatics;Career Choice;Clinical Microbiology;Country;Detection;disorder control;Drug resistance;Ensure;Funding Agency;Genomics;Goals;Health;Human;Infection;Institution;International;Knowledge;Personal Satisfaction;Policies;Population Genetics;Positioning Attribute;Prevention;Research;Research Project Grants;Scientist;skills;Sustainable Development;Training;Training Programs;Trust;United States National Institutes of Health;World Health Organization

PROJECT_TITLE: Research and Capacity Building in Antimicrobial Resistance in West Africa


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ORANGEBURG

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

PHR: NARRATIVE: This Conte Center investigates the slow brain network fluctuations that control the ebb and flow of cognition and related behavioral performance on a moment-by-moment basis. Understanding these slow fluctuations and their underpinnings has broad scientific and public health significance, as they provide critical scaffolding for most, if not all other brain operations. This Center’s discoveries will contribute to the integrated mechanistic understanding of how neural activity and autonomic influences combine in the organization of behavior and cognition and to improved treatment of neural, autonomic and behavioral-cognitive deficits in people with neuropsychiatric disorders.

PI_NAMEs: MILHAM, MICHAEL PETER;SCHROEDER, CHARLES E (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Action Potentials;Address;Adult;Affect;Animals;Area;Attention;Behavior;Behavioral;biophysical model;Brain;Cardiac;cell type;Cells;Cognition;Cognitive;Cognitive deficits;cognitive process;computational network modeling;Computer Models;Costs and Benefits;Coupling;Data;data format;data sharing;Diameter;electrical microstimulation;Electrodes;Electroencephalography;Elements;Epilepsy;experience;Frequencies;functional magnetic resonance imaging/electroencephalography;Genetic;Goals;heart rate variability;Human;human data;Hybrids;imaging study;improved;indexing;Individual;interest;Link;Location;Measurement;Measures;Mental Health;Mind;Modality;Modeling;neural;Neurobiology;Neurons;neuropsychiatric disorder;neuroregulation;nonhuman primate;object recognition;open data;operation;Operative Surgical Procedures;Patients;Pattern;Performance;Periodicals;Persons;Pharmacology;Phase;Physiological;Physiological Processes;Population;programs;Property;Public Health;Pupil;Reaction Time;Research;Resources;Role;Sampling;scaffold;Signal Transduction;Specific qualifier value;Standardization;Stream;Structure;Testing;Time;tool;Update

PROJECT_TITLE: Neurobiology and Cognitive Role of Slow Brain Network Fluctuations


NIH_SPENDING_CATS: Mental Health;Neurosciences

PI_NAMEs: SCHROEDER, CHARLES E (contact)

PROJECT_TITLE: Administrative and Technical Support


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences

PI_NAMEs: MILHAM, MICHAEL PETER (contact)

PROJECT_TERMS: Adaptive Behaviors;Address;Adult;Affect;Archives;Area;Arousal;Attention;Back;Behavior;Behavioral;behavioral response;biophysical model;Brain;Cognition;Cognitive;cognitive benefits;cognitive control;Coupled;Data;data format;Data Set;data standards;design;Dimensions;directed attention;Double-Blind Method;Electrocardiogram;Electroencephalography;Event;experience;experimental study;Feedback;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;Goals;Heart;Human;Impairment;indexing;Investigation;Learning;Link;Maps;Measures;Memory;memory consolidation;memory encoding;memory retention;Mind;Modality;movie;multimodality;Nervous System Disorder;network models;neural;Neurobiology;Participant;Pattern;Performance;Pharmaceutical Preparations;Phase;Physiological;Physiology;Placebos;Probability;Property;Reaction Time;Recurrence;Regulation;Respiration;Rest;Ritalin;Role;Sampling;Signal Transduction;Specific qualifier value;Stimulus;Structure;Task Performances;Testing;Time;Variant;visual tracking

PROJECT_TITLE: Macroscale physiology and functional correlates of slow network fluctuations


PI_NAMEs: KNIGHT, ROBERT THOMAS (contact)

PROJECT_TERMS: Address;Affective;Amygdaloid structure;Anterior;Archives;Area;Attention;Auditory;Auditory area;awake;Behavior;Behavioral;Books;Brain;Brain region;Calcium;Categories;cingulate cortex;Clinical;Cognition;Cognitive;Coupled;Coupling;Data;Data Set;design;developmental disease;directed attention;Disease;Electroencephalography;Electrophysiology (science);Elements;Environment;Epilepsy;Etiology;Event;experience;Eye Movements;Family health status;Family member;Frequencies;functional magnetic resonance imaging/electroencephalography;Goals;Health Personnel;Human;improved;indexing;Individual;Insula of Reil;Interoception;Macaca;Measures;Mental disorders;mental state;Mind;Monitor;movie;Nervous System Disorder;network models;neural;neural circuit;neural network;Neurobiology;Neurons;neuropsychiatric disorder;Occipital lobe;operation;Operative Surgical Procedures;Parietal;Patients;Phase;Physiological;Physiological Processes;Physiology;Population Process;Procedures;Process;Property;Reaction Time;Reading;Reporting;Research;Resolution;Role;Sampling;Scalp structure;Sensory;Signal Transduction;Site;Speech;Stimulus;Stream;Structure;support network;Synapses;Task Performances;Testing;Thinking;Time;Training;Visual;Visual attention;Work

PROJECT_TITLE: Meso-microscale physiology and dynamics of slow network fluctuations


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Mental Health;Neurosciences

PROJECT_TERMS: Animal Model;Anterior;Archives;Area;Arousal;Attention;auditory pathway;Auditory system;Automobile Driving;Back;Basal Nucleus of Meynert;behavior measurement;Behavioral;Biological Models;biophysical model;Brain;Cells;cholinergic;cingulate cortex;Cognitive;Coupling;Data;Data Set;designer receptors exclusively activated by designer drugs;Electric Stimulation;electrical microstimulation;Electroencephalography;Electrophysiology (science);Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Genetic;genetic manipulation;Goals;Human;Implant;interest;Link;Measures;Medial geniculate body;Methods;Microscopic;Modeling;movie;network models;neural network;Neurobiology;neuroimaging;Neurons;neurophysiology;novel;parabrachial nucleus;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Physiological;Physiological Processes;Physiology;Prefrontal Cortex;Process;Pupil;Reaction Time;Rest;Ritalin;Role;Saccades;Scalp structure;Site;Structure;System;Testing;Thalamic structure;Update;vagus nerve stimulation;Vagus nerve structure;Work

PROJECT_TITLE: Multiscale physiology and causal mechanisms of slow network fluctuations


PI_NAMEs: JONES, STEPHANIE RUGGIANO (contact)

PROJECT_TERMS: Anatomy;Area;Arousal;Attention;behavioral outcome;Biological Models;Biophysical Process;Biophysics;Brain;Brain region;Calcium;cell type;Cells;Cognitive;Computer Models;Coupling;Data;data format;design;dynamic system;Electrodes;Electroencephalography;Electrophysiology (science);Exhibits;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Funding;Goals;Grain;Human;insight;Insula of Reil;knowledge integration;Link;Measures;Modality;Modeling;multi-scale modeling;multimodality;neocortical;network models;neural;neural circuit;neural model;Neurobiology;neuromechanism;neuroregulation;Noise;Nonlinear Dynamics;novel;Pattern;phenomenological models;predictive modeling;Process;Property;Resolution;response;Role;Sensory;Shapes;Signal Transduction;Software Tools;spatiotemporal;Standardization;statistics;Stimulus;Structure;Task Performances;Testing;Thalamic structure;tractography;Translating

PROJECT_TITLE: Integrated brain network and cell-circuit models of slow network fluctuations


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: XU, TING  (contact)

PROJECT_TERMS: Address;Anatomy;Biological Models;Brain;Cognitive;Computer Models;Data;Data Analyses;data integration;design;Diffusion;dimension reduction;Dimensions;distributed data;dynamic system;Electrodes;Electroencephalography;Ensure;Event;Frequencies;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Goals;Human;human data;Image;improved;Individual;inter-individual variation;Joints;Link;Macaca;Magnetic Resonance Imaging;Maps;Measurement;Methods;Modality;Modeling;Monkeys;movie;multimodal data;multimodality;neural circuit;neural model;Neurobiology;nonhuman primate;Output;Physiological;Property;Pupil;Reproducibility;Rest;Role;Signal Transduction;spatiotemporal;Surface;T2 weighted imaging;Testing;Work

PROJECT_TITLE: Multimodal Data Analysis and Integration


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: FRANCO, ALEXANDRE R. (contact)

PROJECT_TERMS: Adoption;application programming interface;Behavior;Behavioral;Brain;Brain imaging;BRAIN initiative;Clinical;cloud based;Code;Cognitive;Communities;Computer Models;Computer software;computerized data processing;Data;Data Aggregation;Data Analyses;data archive;Data Collection;data dissemination;data format;data integration;data management;data quality;Data Set;data sharing;data standards;Data Storage and Retrieval;data structure;Databases;design;Development;Diameter;distributed archives;Electroencephalography;Electrophysiology (science);Equipment;experimental study;FAIR principles;Freezing;Frequencies;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Goals;Heart;Human;image registration;imaging system;Institution;International;Laboratories;Magnetic Resonance Imaging;Measures;member;Modality;Morphologic artifacts;multimodal data;National Institute of Mental Health;Nature;Neurobiology;neuroimaging;neurophysiology;nonhuman primate;Online Systems;open source;Physiological;Practice Guidelines;Process;Protocols documentation;Psychophysiology;Pupil;Quality Control;repository;Reproducibility;Research;Research Personnel;Research Support;respiratory;response;Role;Running;Scalp structure;Secure;segmentation algorithm;Signal Transduction;Standardization;Structure;Time;Visual;visual tracking;Work

PROJECT_TITLE: Data Aggregation, Standardization and Sharing


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: The use of radioembolization has been shown to be successful for the treatment and downstaging of hepatocellular carcinoma as well as liver metastases, with response rates of 25-60%. Localized microbubble cavitation triggered by noninvasive ultrasound has been shown to sensitize malignant tissue to radiotherapy by inducing vascular endothelial-cell apoptosis. We propose a first-in-humans randomized clinical trial to determine the benefits of using localized microbubble cavitation to improve patient outcomes and predict treatment response.

PI_NAMEs: ANTON, KEVIN ;EISENBREY, JOHN  (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: 90Y;Adverse event;Aftercare;Apoptosis;Back;blood fractionation;blood perfusion;Blood Vessels;Bolus Infusion;Cancer Etiology;Catheters;Chemoembolization;Clinical;Clinical Trials;Consent;contrast enhanced;contrast imaging;Contrast Media;Data;Disease Progression;dosage;Dose;Early identification;effective therapy;Evaluation;experimental group;Fetal Proteins;first-in-human;follow-up;Glass;Hour;Image;improved;Incidence;Injections;Liver;liver cancer model;liver function;Liver neoplasms;local drug delivery;Magnetic Resonance Imaging;Malignant - descriptor;Measures;Metastatic Neoplasm to the Liver;Microbubbles;Monitor;mortality;nuclear imaging;Nude Rats;Output;Patient Schedules;Patient-Focused Outcomes;Patients;Perfusion;Physiologic pulse;Prediction of Response to Therapy;Primary carcinoma of the liver cells;Progression-Free Survivals;Property;Radiation;Radiation therapy;Radioactive;Radioembolization;Radioisotopes;Radiosensitization;Randomized;randomized, clinical trials;Recovery;Reperfusion Therapy;Reporting;response;Retreatment;Safety;safety and feasibility;Schedule;Solid Neoplasm;Source;Techniques;Testing;Therapeutic;Therapeutic Effect;Therapeutic Embolization;Time;Tissues;tool;treatment response;treatment strategy;tumor;tumor vascular supply;ultrasound;Vascular Endothelial Cell;Vascular Permeabilities;Yttrium

PROJECT_TITLE: Microbubble Cavitation for Improving Hepatocellular Carcinoma Radioembolization

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Hypoxia induces glycolysis enzymes to coalesce into RNP condensates, termed Glycolytic bodies (G bodies), whose formation correlates with increases of glucose flux and cell proliferation in yeast. Using a wide array approaches, we will test the function, structure, and regulation of G body formation in yeast and mammalian systems. This work will reveal mechanisms of condensate function and principles of cell adaptation to hypoxia, providing insights into how cancer cells proliferate in hypoxic tumor microenvironments.

PI_NAMEs: KIM, JOHN  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: 3-Dimensional;Binding;Biochemical;Biogenesis;biophysical analysis;biophysical properties;Biosensor;Caenorhabditis elegans;cancer cell;Cancer cell line;Cell Proliferation;Cell Survival;Cells;Consumption;Cytosol;enzyme activity;Enzymes;Exhibits;Generations;Genetic;genome-wide;Glucose;Glycolysis;Glycolysis Induction;Glycolysis Pathway;Human;Hypoxia;In Vitro;in vivo;insight;Mediating;Metabolic;metabolomics;Mitochondria;Molecular Analysis;novel;Outcome;Oxygen;Pathway interactions;Phase;Physical condensation;Physiological;Production;Proteins;Regulation;Research;Respiration;response;Ribonucleoproteins;RNA;RNA Binding;Role;Signal Pathway;Solid Neoplasm;spheroids;Stress;Structure;System;Testing;Therapeutic;tumor hypoxia;tumor microenvironment;Work;Yeasts

PROJECT_TITLE: Function, regulation, and conservation of hypoxia-induced glycolysis condensates

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: LAS CRUCES

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: Project Narrative A well-trained workforce is essential for maintaining the nation's scientific competiveness and leadership in promoting biomedical research that will improve human health. The G-RISE at New Mexico State University program will increase the number of highly trained PhD recipients who havethe skills, knowledge, creativity, and motivation to find innovative treatments for diseases and disorders that limit longevity and impair the quality of human life.

PI_NAMEs: HOUSTON, JESSICA PEREA (contact);SHUSTER, CHARLES BRADLEY

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: New Mexico;Universities

PROJECT_TITLE: G-RISE at New Mexico State University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]