ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: NARRATIVE: Vertebrate vision starts with a photochemical isomerization reaction involving proteins known as visual pigments that contain retinaldehyde as their chromophore. Despite the fundamental nature of the process and its relevance to human physiology and disease, many of its properties remain poorly understood. Here, we employ a host of new approaches enabled by the development of novel experimental tools to address critical questions pertaining to the functioning of the visual pigments as well as their abnormalities in retinopathies.

PI_NAMEs: KISER, PHILIP DAVID (contact);PALCZEWSKI, KRZYSZTOF

PROJECT_TERMS: absorption;Acceleration;Address;Affect;Agonist;Antibodies;Architecture;ARRB1 gene;Binding;Biochemical;Biological Assay;Biology;Chemicals;Chemistry;chromophore;cis trans isomerization;Complex;Cone;Crystallography;Dark Adaptation;Dependence;Detergents;Deuterium;Development;Disease;experience;experimental study;extracellular;Gases;Glean;Heart;Human;Hydrolysis;In Vitro;in vivo;insight;interest;Isomerism;Isotopes;Kinetics;Knockout Mice;Knowledge;Libraries;Light;Light Adaptations;Lipids;Mass Spectrum Analysis;Membrane;Membrane Proteins;metarhodopsin;Methodology;Methods;Micelles;Modeling;Molecular;Molecular Conformation;mouse model;Mus;Mutagenesis;mutant;nanobodies;Natural regeneration;Nature;novel;novel strategies;Ocular Physiology;Opsin;Penetration;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;Phospholipids;photoactivation;Photobleaching;Photochemistry;Photons;Phototransduction;Physiological;Physiology;Pigments;Play;Process;Property;Protein Conformation;Proteins;Reaction;receptor;regenerative;Research;response;Retina;Retinal Cone;Retinal Diseases;Retinal Pigments;Retinaldehyde;Rhodopsin;Rod Outer Segments;Role;Sampling;Schiff Bases;sensor;Series;Signal Transduction;small molecule;small molecule therapeutics;Stimulus;structural biology;Structure;Structure-Activity Relationship;Surface;Techniques;Testing;therapeutic candidate;Time;tool;Vertebrate Photoreceptors;Vision;Visual;visual cycle

PROJECT_TITLE: Chemical Biology of the Visual Pigments

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: Embryonic stem cells (ESCs) form the basis for transformative cell therapies for retinal blindness, which affects over 300M worldwide. Yet the time-dependent mechanisms by which ubiquitous chromatin modifiers and embryonic transcription factors (TFs) interact to direct ESC retinogenesis remain unknown: the proposed research focuses on how the chromatin regulator WDR5 interacts with p53 and MAX, broadly expressed TFs, to control retinal development. Successful completion of the research will advance key concepts related to birth defects of the retina in p53-associated syndromes, current clinical trials that transplant p53 mutant ESC-derived retinal cells in individuals with macular degeneration, and potential off-target effects of WDR5 inhibitors, which are currently in therapeutic development through a $1 billion effort.

PI_NAMEs: RAO, RAJESH C. (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: 3-Dimensional;Affect;Antibodies;Apoptosis;Award;Binding;Blindness;Cell Fate Control;Cell Therapy;cell type;Cells;Chromatin;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;Congenital Abnormality;CRISPR/Cas technology;Data;Deposition;derepression;Development;Doxycycline;Ectoderm;Embryo;Embryoid bodies;embryonic stem cell;Epiblast;ES Cell Line;Event;Flow Cytometry;gene repression;Genes;Genetic Transcription;Germ Cells;Glean;Guide RNA;Histone H3;histone modification;Immunofluorescence Immunologic;in vivo;Individual;inhibitor;innovation;insight;Intervention;Knowledge;Leucine Zippers;loss of function;Lysine;Macular degeneration;Maps;Medical;Meiosis;Mental Depression;Mesoderm;Mesoderm Cell;Methylation;Molecular;Mouse Embryonic Stem Cells;mutant;Neuroectoderm;Nuclear;Organoids;outcome prediction;Pathway interactions;Phenotype;Population;Proliferating;Proteins;recruit;Repression;Research;Retina;Retinal Defect;retinal progenitor cell;retinogenesis;Role;single-cell RNA sequencing;Source;Specific qualifier value;Structure of primordial sex cell;Syndrome;Technology;Testing;therapeutic development;Therapeutic Effect;Therapy trial;Time;TP53 gene;TP73 Protein;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomic profiling;translational impact;Transplantation;trophoblast;tumorigenesis;Up-Regulation;Visual Fields

PROJECT_TITLE: Molecular Determinants for WDR5-Driven Transcriptional Regulation at Lineage-Specifying Genes During Retinogenesis

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Narrative There are continual threats of chemical exposure to human populations. Health and safety measures in the workplace cannot fully mitigate the chances of unexpected or malicious use of chemical toxicants. This project will broadly impact human welfare by developing safe and effective countermeasures to cyanide intoxication.

PI_NAMEs: DAVISSON, VINCENT JO (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Affinity;Animal Model;beta-mercaptopyruvate;Biological Availability;Chelating Agents;Chemical Agents;Chemical Exposure;chemical stability;chemical threat;Chemicals;cobinamide;comorbidity;Complex;Cyanides;Data;design;efficacy evaluation;emergency settings;Ensure;Equilibrium;Evaluation;Exhibits;experience;Exposure to;Formulation;glyoxylate;Health;Human;Hydrogen Cyanide;improved;In Vitro;in vivo;in vivo Model;Intervention;Intoxication;Intramuscular;Intramuscular Injections;Lead;lead candidate;Ligands;Measures;Medical;medical countermeasure;Metabolic;metabolic poison;Metabolism;Metals;Modern Medicine;Morbidity - disease rate;mouse model;Mus;next generation;Oryctolagus cuniculus;Outcome;Oxidation-Reduction;Pharmaceutical Chemistry;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacy (field);Phase;Phenotype;Platinum;Poison;Population;porcine model;primary endpoint;Property;Protective Agents;Publishing;Reaction;Reproducibility;Research Personnel;Risk;Safety;scale up;Selection Criteria;Series;Sodium;Structure;success;Sulfides;Testing;Therapeutic Agents;toxicant;Toxicology;Toxin;welfare;Work;Workplace;Zebrafish

PROJECT_TITLE: Platinum Based Countermeasures and Combinations with Protective Agents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-P (50)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Nutrition;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE Increasing evidence supports the role of arsenic exposure in diabetes development. We will evaluate novel epitranscriptomic mechanisms linking arsenic to diabetes and metabolic dysfunction in American Indian communities. This study can provide insight into novel pathways of arsenic related diabetes, identify prevention interventions, and inform recommendations for arsenic levels in water and food.

PI_NAMEs: BACCARELLI, ANDREA ;MASON, CHRISTOPHER EDWARD;NAVAS-ACIEN, ANA  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Adult;Affect;Albuminuria;American Indian community;American Indian Population;Arizona;Arsenic;Beta Cell;Biological;Blood;Blood Cells;blood glucose regulation;Cause of Death;Cellular Stress;Childhood;Clinical;Clinical Data;Clinical Markers;cohort;Data;design;Development;diabetes control;Diabetes Mellitus;diabetes mellitus therapy;Disputes;DNA Methylation;Elderly man;Environmental Pollutants;epigenomics;epitranscriptome;epitranscriptomics;Exposure to;fat mass and obesity-associated protein;Fingerprint;follow-up;Food;Functional disorder;Funding;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Glucose;Glycosylated Hemoglobin;Heart;Hepatic;histone modification;Human;Immune response;Individual;Inflammation;Infrastructure;insight;Insulin;Insulin Resistance;Intervention;Investments;Joints;Life;Link;Lipids;Liver;Longitudinal Studies;Machine Learning;Measures;Mendelian randomization;Messenger RNA;Metabolic dysfunction;Metabolic Marker;Metabolic syndrome;Modification;multidimensional data;Names;Non-Insulin-Dependent Diabetes Mellitus;novel;Oklahoma;Oxidative Stress Induction;Participant;Pathogenesis;Pathway interactions;Phenotype;phenotypic data;Pilot Projects;Plasma;Play;Population;Prevalence;Preventive;preventive intervention;Process;Proteins;Reader;Recommendation;Research;Resources;response;Risk;RNA;RNA Stability;Role;Schedule;Serum;Severities;Shapes;South Dakota;statistical and machine learning;System;systemic inflammatory response;Testing;Tissues;toxicant;Transcript;Translations;United States;Visit;Water;Whole Blood

PROJECT_TITLE: The Epitranscriptome as a Novel Mechanism of Arsenic-Induced Diabetes.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(02)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE This project is in line with the NEI mission to support research studying visual disorders and their mechanisms. It aims to enhance our knowledge of the mechanisms underlying retinal ischemic diseases including diabetic retinopathy, glaucoma, retinopathy of prematurity, and vein occlusion. Moreover, the project has the potential to translate the cross talk between the arginase pathway and histone deacetylase 3 in myeloid cells as a new therapeutic target for these retinal disorders.

PI_NAMEs: FOUDA, ABDELRAHMAN  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Abbreviations;Academia;Anabolism;ARG2 gene;arginase;Arginine;arm;Award;Bioenergetics;Blindness;Blood Vessels;career;career development;Career Mobility;Cells;Cessation of life;chromatin modification;Chronic;Clinical;Data;diabetic;Diabetic Retinopathy;Disease;effective therapy;Enzymes;Flow Cytometry;Functional disorder;Genetic Transcription;Glaucoma;Goals;Grant;HDAC3 gene;Histone Deacetylase;Immune;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;Institution;Interleukin-1 beta;Investigational Drugs;Ischemia;ischemic injury;knock-down;Knockout Mice;Knowledge;Laboratories;Laboratory Finding;Macrophage;Mass Spectrum Analysis;Mediating;Mediator;Mentors;Metabolic;Metabolism;Mission;Mitochondria;Mus;Myelogenous;Myeloid Cells;Nerve Degeneration;Neuronal Injury;neuroprotection;neurovascular;neurovascular injury;new therapeutic target;Nitric Oxide;Nitric Oxide Synthase;NOS2A gene;novel;novel therapeutics;Ornithine;Ornithine Decarboxylase;Outcome;Oxidative Stress;Paper;Pathologic Processes;Pathology;Pathway interactions;Pattern;Phase;Phenotype;Polyamines;Production;programs;protective effect;Protein Isoforms;Publishing;Putrescine;Recombinants;repair function;Reperfusion Injury;Reperfusion Therapy;Research;Research Personnel;research study;Research Support;Retina;Retinal Diseases;retinal ischemia;retinal neuron;Retinopathy of Prematurity;Role;Science;Secure;Signal Transduction;skill acquisition;Stress;Testing;Therapeutic;TNF gene;Training;Translating;Translational Research;Up-Regulation;Urea;urea cycle;Vascular Diseases;vascular injury;vein occlusion;Vision Disorders;Vision research;vision science

PROJECT_TITLE: Role of Arginase 1 in Retinal Ischemia-Reperfusion Injury

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis, vasculopathy, and inflammation. Like many autoimmune diseases, the incidence of SSc in women is much greater compared with men. The studies in this proposal will investigate the effect of the sex hormone estrogen on the activation of macrophages, a type of white blood cell that has been implicated in SSc pathogenesis.

PI_NAMEs: WHITFIELD, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: 3-Dimensional;Address;Affect;Autoimmune Diseases;biological research;Biology;Case Fatality Rates;CCL2 gene;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chronic autoimmune disease;Clinical;clinically significant;Coculture Techniques;Collaborations;comorbidity;Data;Data Set;Death Rate;defined contribution;Development;Diagnosis;Disease;disease diagnosis;Disease Progression;Estradiol;Estrogen Receptors;Estrogens;Estrone;Etiology;Extracellular Matrix;FDA approved;Female;Fibroblasts;Fibrosis;Frequencies;Funding;Gene Expression;Goals;Gonadal Steroid Hormones;Heterogeneity;hormonal contraception;human disease;Immune;immune activation;immune function;Immune response;Immunologist;Incidence;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;inhibitor;Interleukin-6;Knowledge;Leukocytes;Macrophage;Macrophage Activation;Maintenance;Mediating;men;Modeling;Molecular;Myelogenous;novel;parent project;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Phosphorylation;Play;Population;Postmenopause;Publishing;Regimen;Regulation;Replacement Therapy;Research;Role;Sampling;Sex Bias;Sex Differences;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;Standardization;STAT3 gene;Strategic Planning;Surface;Systemic Scleroderma;Systemic Therapy;targeted treatment;Technology;Testing;Therapeutic;Time;Tissues;treatment strategy;United States National Institutes of Health;Up-Regulation;Vascular Diseases;vascular injury;Woman;women's diagnosis;Women's Health;Work

PROJECT_TITLE: Estrogen Regulation of Macrophage Activation in Systemic Sclerosis


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Complementary and Integrative Health;Natural Products;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Unintentional Childhood Injury

ORG_CITY: MEMPHIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: The neonatal brain is very vulnerable to compromises in its blood supply. Cerebral vascular dysfunction caused by excessive production of reactive oxygen species during asphyxia in babies disrupts brain homeostasis and frequently produces lifelong complications. We are searching for novel mechanism-based approaches to neonatal cerebral vascular protection during oxidative stress to benefit the outcome of neonatal asphyxia.

PI_NAMEs: PARFENOVA, HELENA  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Affect;Animal Model;antioxidant therapy;Antioxidants;Apoptotic;Asphyxia;Asphyxia Neonatorum;Astrocytes;Blood - brain barrier anatomy;blood-brain barrier disruption;blood-brain barrier function;Brain;brain endothelial cell;brain tissue;Cells;Cerebral cortex;Cerebral endothelium;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrovascular Physiology;Cerebrum;clinically relevant;Combined Modality Therapy;comparative efficacy;Data;Defense Mechanisms;Development;Endothelial Cells;endothelial dysfunction;Endothelium;excitotoxicity;Exhibits;Exposure to;Family suidae;Functional disorder;Gene Silencing;Generations;Glutamates;Head;Health;Homeostasis;Hypoxia;improved;improved outcome;In Vitro;in vivo;in vivo Model;indexing;Infant;Inflammation;Inflammatory;inhibitor;Injury;Investigation;Modeling;Molecular;Morbidity - disease rate;NADPH Oxidase;natural hypothermia;Neonatal;neonatal brain;Neonatal Brain Injury;neonatal encephalopathy;neonate;neurological recovery;neurovascular;neurovascular unit;Newborn Infant;novel;novel therapeutic intervention;novel therapeutics;Outcome;Oxidative Stress;peripheral blood;Phytochemical;Predisposition;preservation;prevent;Prevention;Production;Property;Reactive Oxygen Species;Regulation;Research;Source;standard care;Stimulus;Sulforaphane;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;Translating;Vascular blood supply;Vascular Endothelium;vascular factor;vascular injury;Vasodilator Agents

PROJECT_TITLE: Neonatal cerebral vascular injury by prolonged asphyxia

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Comparative Effectiveness Research;Health Services;Mental Health;Mental Illness;Rehabilitation

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative We propose to develop a routine monitoring system for psychological interventions in public hospitals in Kenya named MarBar-Africa. There is no such system in Kenya to improve the quality of service or provide feedback to patients and/or providers on the progress and effectiveness of treatments offered in routine care. MarBar will be an open source system that, once it has been tested, any clinicians forming a collaboration and researchers can use it within the country.

PI_NAMEs: HUANG, KENG-YEN ;KUMAR, MANASI  (contact)

PROGRAM_OFFICER_NAME: CUBILLOS, LEONARDO

PROJECT_TERMS: acceptability and feasibility;Adopted;Africa;African;Agreement;Assessment tool;Caring;Characteristics;Clinic;Clinical;clinical decision-making;clinical practice;Clinical Practice Patterns;Clinical Psychology;Collaborations;Colombia;Community of Practice;Comparative Effectiveness Research;Competence;cost;Country;County;dashboard;Data;Data Collection;design;Development;Diagnostic;Disease remission;Distress;Ecuador;Effectiveness;Effectiveness of Interventions;electronic medical record system;Ensure;Evaluation;experience;Feasibility Studies;feasibility testing;Feedback;field study;functional improvement;Goals;Health Personnel;Health system;Healthcare;Healthcare Systems;Hospitals;implementation science;improved;International;Internet;Intervention;intervention delivery;Journals;Kenya;Knowledge;Learning;low and middle-income countries;Maps;Measurement;Measures;Mental disorders;Mental Health;Mental Health Services;Methods;Mexico;Modeling;Monitor;Names;open source;Outcome;Participant;Partnership Practice;Patient Care;patient oriented;patient response;Patient Self-Report;patient-clinician communication;Patient-Focused Outcomes;Patients;Persons;pilot test;Policies;Preparation;Procedures;Process;Prognosis;prototype;Provider;Psychiatry;psychologic;Psychopathology;Psychotherapy;Public Health;Public Hospitals;Publications;Quality of Care;Quality of life;Questionnaires;Reduce health disparities;Research;Research Personnel;Resource-limited setting;Resources;routine care;Services;Site;South American;Specialist;Subgroup;System;Systems Development;Testing;Therapeutic;Time;tool;Training;Translations;treatment center;Treatment Effectiveness;treatment optimization;web app;Work

PROJECT_TITLE: Testing development, acceptability, feasibility and costing of MARBAR-Africa (a routine outcome interactive measurement dashboard) for improved psychotherapy outcomes in specialist public health care

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (04)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Rural Health;Substance Misuse

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: West Virginia has the lowest life expectancy in the nation and ranks at or near the bottom in many chronic disease categories. The overarching goal of the West Virginia Clinical and Translational Science Institute is to grow research that accelerates delivery of solutions to health disparities in West Virginia.

PI_NAMEs: HODDER, SALLY LYNN (contact)

PROGRAM_OFFICER_NAME: BISSONETTE, GREG

PROJECT_TERMS: 2019-nCoV;Academic Medical Centers;Acceleration;addiction;Address;Alzheimer's Disease;Appalachian Region;Award;Cardiovascular Diseases;Categories;Chronic Disease;Chronic lung disease;Clinical;Clinical Research;Clinical Sciences;cohort;Cohort Studies;Collaborations;Color;Communication;Communities;community engagement;Community Outreach;County;COVID-19;COVID-19 pandemic;COVID-19 patient;Death Rate;Development;Environmental Hazards;equity, diversity, and inclusion;Exposure to;Funding;Goals;Grant;Health;health care service organization;health disparity;Health Resources;HIV;Human;Human Resources;improved;Incidence;Institution;Lead;Leadership;Life Expectancy;Malignant Neoplasms;Medical center;medical schools;National Institute for Occupational Safety and Health;new epidemic;next generation;Osteopathic Medicine;Outcome;Policies;Positioning Attribute;Post-Acute Sequelae of SARS-CoV-2 Infection;practice-based research network;predictive modeling;Primary Care;Productivity;programs;Public Health;Publications;Registries;reproductive;Research;Research Infrastructure;Research Personnel;Rural Community;Rural Health;Rural Population;Science;Scientist;Site;substance use;Substance Use Disorder;success;Testing;Training;Translational Research;translational scientist;Trust;United States;United States Department of Veterans Affairs;United States National Institutes of Health;West Virginia;Work

PROJECT_TITLE: West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: FAYETTEVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

PHR: PROJECT NARRATIVE Obesity is marked by metabolic dysregulation and a well-known comorbidity in female breast cancer. Interestingly, obese mammary adipose tissue contains significantly thicker and aligned collagen I fibers, which might drive breast tumor innervation, as neurites are known to prefer extending along aligned extracellular matrix fiber organization. The overall goal of this supplement research is to probe the specific effects of obesity-driven altered extracellular matrix topography in breast tumor innervation.

PI_NAMEs: QUINN, KYLE PATRICK (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Administrative Supplement;Animals;Arkansas;Automobile Driving;Award;Bioenergetics;Biological Assay;Biomedical Research;Brain-Derived Neurotrophic Factor;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Breast Epithelial Cells;cancer initiation;Cell Communication;Cells;Centers of Research Excellence;Chronic Disease;Coculture Techniques;Collagen;Collagen Fiber;Collagen Type I;comorbidity;Complex;Confocal Microscopy;Consumption;Custom;cytokine;Data;Data Science;density;Dependence;design;Development;Devices;Disease;Extracellular Matrix;Female Breast Carcinoma;Fiber;Future;Genus Hippocampus;Glucose;glucose metabolism;Glutaminase;Glutamine;Goals;Human;Hydrogels;Image;Immunofluorescence Immunologic;In Vitro;in vitro Model;Infiltration;inhibitor;Interdisciplinary Study;interest;Invaded;Investigation;lactate dehydrogenase A;life span;Link;Lipids;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Neoplasms;MCF10A cells;Measures;Mediating;Metabolic;metabolic profile;Metabolism;microscopic imaging;Modeling;multiphoton microscopy;National Cancer Institute;Neoplasm Metastasis;Nerve;Nerve Growth Factors;nerve supply;Neurites;Neuroglia;neurotrophic factor;Neurotrophin 3;Obesity;Optics;Oxidation-Reduction;Parents;Patients;Pattern;Phase;premalignant;Prognosis;Publications;Rattus;repaired;Research;Role;Sampling;Spinal Ganglia;Sprague-Dawley Rats;Stretching;Stromal Cells;Survival Rate;Testing;Thinness;three dimensional cell culture;Tissue Engineering;Tissues;Treatment outcome;tumor;tumor microenvironment;Universities;Women's Health

PROJECT_TITLE: Arkansas Integrative Metabolic Research Center


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Inflammatory Bowel Disease;Liver Disease;Microbiome

ORG_CITY: EAST LANSING

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative  Research into the human microbiome has begun to show that microbial modification of host molecules can affect health and disease. We recently discovered that the microbiome modifies host bile acids by acyl-conjugation of the steroid core with amino acids, creating a hidden and diverse component of the human bile acid pool. This project will deeply explore how these molecules are made and how their bioactivity can alter inflammatory signaling in disease models to better understand their role in human health and potential use as drugs to treat GI disease.

PI_NAMEs: QUINN, ROBERT ANDREW (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Active Sites;Acyltransferase;Affect;Agonist;Amino Acids;Anti-Inflammatory Agents;Automobile Driving;Bacteria;base;Basic Science;Bile Acids;bile salts;Biochemical;Biochemistry;Biological Assay;Cell Culture Techniques;Cell Survival;Cells;Charge;Chemicals;Chemistry;Circulation;Cloning;Coenzyme A;Colon;Crohn's disease;Data;Detergents;Development;dextran sulfate sodium induced colitis;Diet;dietary control;Dietary Fats;Disease;disease model;Disease Outcome;Enterohepatic Circulation;Enzymes;Epithelial Cells;Escherichia coli;experimental study;Family;Foundations;Funding Opportunities;Future;gastrointestinal;Gastrointestinal Diseases;gastrointestinal epithelium;Gastrointestinal Physiology;Gastrointestinal tract structure;Glycine;Goals;GPBAR1 gene;gut bacteria;gut health;gut inflammation;gut microbiome;Health;Health Promotion;Homeostasis;host microbiome;host-microbe interactions;Human;Human Microbiome;Hydrolase;Hydrolysis;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Knockout Mice;Knowledge;knowledge base;Laboratories;Language;Liver;Metabolic;Metabolism;Michigan;Microbe;microbial;Microbial Physiology;Microbiology;microbiome;Modification;Molecular;mouse model;Mus;Mutate;novel;novel therapeutics;Organoids;Outcome;Pharmaceutical Preparations;Physiological;Physiology;pressure;Production;Proline;Property;receptor;Receptor Cell;Regulation;Research;Resistance;Resources;response;Role;Sampling;Shapes;Signal Transduction;Signaling Molecule;small molecule;Specificity;Steroids;Structure;Taurine;Testing;transcriptomics;Transferase;Translating;Translations;United States National Institutes of Health;Wild Type Mouse

PROJECT_TITLE: Prioritization and Bioactivity Characterization of Novel Bile Acids Produced by the Microbiome

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Many urban settings including Baltimore face dual opioid and HIV epidemics, one among older predominantly minority PWID who are disproportionately affected with HIV, and an emerging epidemic among younger white individuals living in suburban Baltimore who are at high risk for HIV. The findings from this study will inform both interventions targeting new PWID populations at risk for HIV as well as programs to optimize engagement of PWID in care and treatment for not only for HIV but for non-communicable diseases which will improve overall health and well-being.

PI_NAMEs: KIRK, GREGORY D;MEHTA, SHRUTI H (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;African American;African American population;age related chronic disease;Aging;Alcohols;Ancillary Study;Anti-HIV Agents;Baltimore;Behavioral;Biological;Cardiovascular Diseases;Caring;Chronic Obstructive Pulmonary Disease;Cities;cohort;Collaborations;Communities;comorbidity;Continuity of Patient Care;Data;Data Collection;Diabetes Mellitus;Disease;Disease Progression;Disparity population;disparity reduction;drug testing;Drug usage;Epidemic;Epidemiology;experience;Face;follow-up;Foundations;frailty;Funding;Future;Gender;Generations;Geography;Grant;Health;Health trends;Hepatitis C;Hepatitis C Vaccine;high risk;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV/AIDS;HIV/HCV;holistic approach;Hyperlipidemia;Hypertension;improved;Incidence;Individual;Infrastructure;Injecting drug user;insight;Intervention;Intravenous;Investigation;Joints;Kidney Diseases;Learning;Life;Life Cycle Stages;life span;Link;Liver diseases;Lung Diseases;male;Measures;Medical;Medical Records;Metabolic Diseases;Methodology;Methods;mHealth;Minority;Minority Groups;Monitor;Morbidity - disease rate;mortality;new epidemic;novel;Opioid;opioid epidemic;opioid use;Outcome;Overdose;overdose death;Participant;Pathogenesis;Pattern;Peer Review;Personal Satisfaction;Pharmaceutical Preparations;platform-independent;polysubstance use;Population;Populations at Risk;prescription opioid;Prevalence;Productivity;programs;Public Health;Publications;Quality of life;recruit;Reporting;Research;Research Personnel;Research Priority;Research Training;residence;Risk Behaviors;Sentinel;smoking cessation;substance use;suburb;success;Time;Time trend;Training;Treatment outcome;trend;United States National Institutes of Health;urban setting;Viral Load result;Woman;Work

PROJECT_TITLE: AIDS Linked to the IntraVenous Experience (ALIVE)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project narrative  The proposed research is relevant to public health because it focuses on defining the neuroadaptations that underlie cocaine use disorder. These studies will determine how activity of a gene called Rac1 disproportionately effects cocaine-activated neurons compared to food-activated neurons, and may form a foundation for new strategies for treating cocaine use disorder. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to reducing illness and disability

PI_NAMEs: WARREN, BRANDON L (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Address;Affect;Automobile Driving;Behavior;Behavioral;Brain;Brain region;Calcium;Cell Physiology;Cellular Structures;Clinical;clinical development;Cocaine;Cocaine Dependence;cocaine relapse;cocaine seeking;cocaine self-administration;Cocaine use disorder;craving;cue reactivity;Cues;density;Development;differential expression;Dimensions;disability;Down-Regulation;Drug Addiction;experience;experimental study;Food;FOS gene;Foundations;Functional disorder;Genes;Glutamates;Goals;Guanosine Triphosphate Phosphohydrolases;Image;Immediate-Early Genes;in vivo;in vivo calcium imaging;innovation;insight;Investigational Therapies;Learning;Measures;Mediating;Memory;Mental disorders;Methods;Mission;Modeling;Molecular;Morphology;neural;neuroadaptation;neuromechanism;Neurons;Outcome;Pattern;Pharmaceutical Preparations;Positioning Attribute;promoter;Psychological reinforcement;Public Health;Rattus;recruit;Regulation;reinforcer;Relapse;Research;Rewards;Rodent;Role;sensor;Signal Transduction;small molecule;Structure;synaptogenesis;Tamoxifen;Testing;United States National Institutes of Health;Up-Regulation;Vertebral column;Work

PROJECT_TITLE: The role of neuronal ensemble Rac1 activity in cocaine seeking behavior

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: MOSCOW

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: Project Narrative Maternal and infant health are a growing concern worldwide, especially related to underserved populations. The research proposed will attempt to assess the impact of socioeconomic, demographic, policy, health, and healthcare factors on maternal and infant health, using geospatially explicit modeling techniques across the state of Idaho. By better understanding the spatiotemporal interactions and effects of these set of variables on maternal and infant health, we seek to provide more quantitatively focused recommendations to policymakers, community leaders, and others who shape the decisions effecting women’s overall health outcomes.

PI_NAMEs: WICHMAN, HOLLY A (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: access disparities;Address;Affect;Age;Alaska Native Women;Algorithms;application programming interface;Area;Biomedical Research;Birth;black women;Caring;Case Study;Cessation of life;Communities;community engagement;community organizations;comorbidity;Complex;Computer Models;Country;County;dashboard;Data;Data Analyses;Death Rate;demographics;Diabetes Mellitus;Discipline;Economically Deprived Population;Economics;Education;Educational workshop;Ethnic Origin;Experimental Designs;Formulation;Funding;geographic barrier;Geography;Goals;Guidelines;Health;health care availability;health care service;Health Insurance;Health Services Accessibility;Health system;Healthcare;Heart Diseases;Hemorrhage;Hispanic Populations;Hispanic Women;Hospitals;Hypertension;Idaho;improved;Income;Infant;Infant Health;Infection;insight;Knowledge;Leadership;Live Birth;Low Birth Weight Infant;Malignant Neoplasms;Maternal Health;maternal morbidity;Maternal Mortality;Mathematics;Measurement;Measures;Medicare;model development;Modeling;Modification;Molecular;mortality;Native Americans;neural network;Nonprofit Organizations;Obesity;obstetric services;Outcome;Output;parent project;people of color;Perinatal;Policies;Policy Maker;Political Factor;Population;Populations at Risk;postnatal;postpartum care;Poverty;Premature Birth;prenatal;Privatization;Production;Race;random forest;Recommendation;Research;Research Methodology;Research Personnel;Risk;Running;rurality;Series;Services;Shapes;social health determinants;socioeconomics;Sociology;spatiotemporal;Structure;Surveys;Techniques;Technology;Time;tool;transportation access;trend;underserved community;Underserved Population;United States;Update;Variant;welfare;Woman;Women's Health;Work

PROJECT_TITLE: Center for Modeling Complex Interactions


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Data Science;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Radiation Oncology

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Image-guided thermal ablation treatment is a minimally invasive, low cost, and accessible renal cancer treatment for patients including those who are too ill to be candidates for surgery or radiotherapy. However, it remains under-utilized due to relatively higher post-procedure recurrence rates when compared to traditional intervention, such as surgical resection. The proposed research program aims to curate a large database of intra and peri-procedural ablation imaging that will be used to develop computer vision algorithms for improving treatment efficacy and broaden the applicability and success of these treatments.

PI_NAMEs: BAI, HARRISON ;KIMIA, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: 3-Dimensional;Ablation;Active Learning;Address;Aftercare;Algorithms;Architecture;Automated Annotation;automated segmentation;base;Biomechanics;cancer therapy;Characteristics;Clinic;clinical application;Computer software;Computer Vision Systems;convolutional neural network;cost;cost effective;Data;Data Set;Databases;deep learning;deep learning algorithm;density;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Disease;Early Diagnosis;Excision;experience;follow-up;human-in-the-loop;Image;Image Analysis;image guided;image registration;imaging scientist;improved;improved outcome;Intervention;Kidney;kidney imaging;Kidney Neoplasms;learning strategy;Lesion;Literature;liver tumor ablation;Localized Disease;Malignant Neoplasms;Manuals;Maps;Medical Imaging;Methodology;Methods;minimally invasive;Modeling;Monitor;Morbidity - disease rate;Neoplasms;neural network;novel;Operative Surgical Procedures;Organ;Patients;Performance;Physicians;prevent;Procedures;Process;programs;quantitative imaging;Radiation therapy;radiologist;Recurrence;Renal Carcinoma;Renal Cell Carcinoma;Research;segmentation algorithm;Semantics;Software Framework;Speed;Structure;success;System;Techniques;Technology;Thermal Ablation Therapy;Time;Treatment Efficacy;tumor;tumor ablation;Tumor Volume;United States;vector;virtual;Work

PROJECT_TITLE: Employing quantitative image analysis based on deep learning to improve treatment efficacy in image-guided renal tumor ablation

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (M2)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Lung;Orphan Drug;Physical Injury - Accidents and Adverse Effects;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Relevance Phosgene gas is a terrorism and warfare agent and, due to transport and industrial accidents, has injured many Americans. Currently, no effective treatment for phosgene gas-induced lung injuries is available. Our proposal will identify and optimize potential therapeutic lead compounds that mitigate lung injury and inflammation in mice and swine for future development as a human treatment of this devastating injury under the United States Food and Drug Administration’s (US FDA) animal rule.

PI_NAMEs: ACHANTA, SATYANARAYANA  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acids;Acute Respiratory Distress Syndrome;Airway Fibrosis;airway remodeling;airway repair;Aldosterone;American;Angiotensin-Converting Enzyme Inhibitors;Animal Euthanasia;animal rule;Animals;Antidotes;authority;Biomedical Research;Blood;Bronchoalveolar Lavage Fluid;Captopril;Cardiopulmonary;Cell Count;Cells;chemical threat;Chemical Weapons;Chemicals;Chlorides;Chronic;cytokine;Data;Development;Dose;drug candidate;Drug Kinetics;Drug Targeting;drug testing;Dyes;Dyspnea;Edema;effective therapy;efficacy testing;Enalapril;Enzymes;Epoxide hydrolase;Epoxy Compounds;Family suidae;Female;Frequencies;Functional disorder;Future;gas induced lung injury;Gases;Histopathology;Homeostasis;Hour;Human;humane endpoint;Hydrolysis;Hypoxia;improved;Inbred BALB C Mice;Industrial Accidents;Inflammation;Inflammatory;Inhalation;inhibitor;injured;Injury;Lead;lead candidate;lipid mediator;liquid chromatography mass spectrometry;Lisinopril;Literature;Lung;lung injury;male;manufacture;Measurement;Mediating;Mediator;medical countermeasure;methacholine;Modeling;Monitor;Morbidity - disease rate;mortality;mouse model;movement analysis;Mus;Outcome Study;Pathway interactions;Peptidyl-Dipeptidase A;Personal Satisfaction;Pharmaceutical Preparations;Pharmacologic Substance;Phosgene;Plasma;Play;Polymers;porcine model;primary endpoint;programs;Proteins;Pulmonary Edema;Pulmonary Emphysema;Pulmonary Fibrosis;pulmonary function;Pulmonary Inflammation;Recovery;Regimen;Renin-Angiotensin-Aldosterone System;research and development;Resolution;respiratory challenge;Risk;secondary endpoint;severe injury;standard of care;Survival Rate;Survivors;symptom treatment;targeted treatment;Terrorism;therapeutic evaluation;therapeutic lead compound;Transportation;Treatment Efficacy;United States Food and Drug Administration;vascular injury;weapons;White Blood Cell Count procedure;Work;World War I

PROJECT_TITLE: Identification and optimization of medical countermeasures for phosgene inhalation injuries


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Precision Medicine;Women's Health Research

PHR: PROJECT NARRATIVE Breast cancer kills more than 40,000 individuals annually in the US alone, largely because most patients that have advanced estrogen receptor (ER)-positive breast cancer have tumors that develop so-called ”endocrine resistance” to anti-cancer therapy. We have identified three previously unknown types of ER mutations in advanced tumors in multiple patients, and found that they directly make these tumors endocrine resistant, which poses a major problem in the clinical setting. This proposal aims to study these novel ER-mutated tumors and determine 1) how the mutations make tumors resistant, and 2) whether they will respond to the newest class of anti-cancer drugs; the ultimate aim is to find the best therapeutic approaches to transform clinical care for patients whose tumors have these novel ER-mutated tumors.

PI_NAMEs: NAYAR, UTTHARA  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Adoption;Amino Acid Substitution;Animals;Antineoplastic Agents;ATAC-seq;Biological Assay;Biological Markers;Biology;Breast Cancer Model;cancer therapy;CDK4 gene;Cell Line;Clinic;Clinical;clinical biomarkers;clinical care;clinical decision-making;Clinical Trials Design;cofactor;Development;Effectiveness;Endocrine;Endocrine Gland Neoplasms;Engineering;epigenomics;Estrogen Antagonists;Estrogen receptor positive;Estrogen Receptors;Estrogen Therapy;Evolution;exome sequencing;Foundations;Frequencies;Future;gain of function;genetic signature;Genetic Transcription;Grant;hormone therapy;Hyperactivity;Incidence;Individual;individualized medicine;inhibitor;innovation;Ligand Binding Domain;Ligands;Malignant Breast Neoplasm;Metastatic breast cancer;Mission;Modeling;mortality;mouse model;mutant;Mutate;Mutation;novel;Oncogenic;Oral;Organoids;overexpression;Patient Care;patient population;patient stratification;Patient-Focused Outcomes;Patients;Phenotype;Pilot Projects;Positioning Attribute;potential biomarker;pre-clinical;precision medicine;preclinical study;predicting response;predictive marker;Prognosis;Proteomics;receptor binding;Receptor Inhibition;Receptor Signaling;Regimen;Reporter;Research Design;Resistance;Resistance development;resistance mechanism;response;Role;Signal Transduction;Structural Models;Structure;targeted treatment;Therapeutic;Toxic effect;Transactivation;transcriptome sequencing;transcriptomics;Translating;treatment choice;treatment response;tumor;tumor progression;Variant;variant of unknown significance;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Novel estrogen receptor mutations as a biomarker dictating therapy response in advanced endocrine-resistant estrogen receptor-positive breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (M1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome;Precision Medicine;Sarcoidosis

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: NARRATIVE Sarcoidosis is an enigmatic disease that varies from mild to life-threatening, is difficult to diagnose and even more difficult to predict. Our project aims to identify biomarkers that can help us accurately diagnose and characterize patients, particularly those most likely to be severely affected, and also to understand disease mechanisms. This project will capitalize on our unique combination of unmatched data, cutting-edge technologies, and dedicated researchers to lay the groundwork for diagnostic, prognostic, and treatment advances.

PI_NAMEs: MONTGOMERY, COURTNEY  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: accurate diagnosis;adaptive immune response;Affect;African ancestry;American;Bioinformatics;Biological;Biological Markers;biological systems;biomarker identification;Bronchoalveolar Lavage Fluid;burden of illness;Candidate Disease Gene;candidate identification;Cells;Clinical;Clinical Data;clinical heterogeneity;cohort;cytokine;Data;data integration;Data Set;Dedications;Diagnosis;Diagnostic;differential expression;Disease;disease model;Disease Outcome;Dissection;Drug Targeting;Environmental Risk Factor;Etiology;European ancestry;experience;follow-up;Foundations;Genes;Genetic;genetic analysis;Genetic Predisposition to Disease;genome wide association study;genomic data;Genomics;Goals;Granuloma;Granulomatous disease;Immune;Immune response;Immunologics;Immunologist;in silico;Inflammatory Response;Innate Immune Response;innovation;interest;Lavage;Life;Machine Learning;Measures;Medical;member;Modeling;Molecular Profiling;Morbidity - disease rate;mortality;multidimensional data;Multiomic Data;multiple omics;novel;novel strategies;Organ;Outcome;Pathway interactions;Patients;Plasma;Play;Population;predictive modeling;Predisposition;Prognosis;prognostic;Proteins;Proteomics;Publishing;Pulmonary Fibrosis;Rare Diseases;Research;Research Personnel;Sampling;Sarcoidosis;Sensitivity and Specificity;Severities;Severity of illness;single-cell RNA sequencing;Source;success;Susceptibility Gene;Systemic disease;Technology;Testing;therapeutic target;Tissues;Trans-Omics for Precision Medicine;transcriptomics;Variant;virtual;Work

PROJECT_TITLE: Multi-Omic Characterization of Immune Cells in Sarcoidosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (M1)]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Genetics;Pediatric;Prevention;Stroke

ORG_CITY: CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE This research aims to pinpoint genetic mutations and cellular mechanisms involved in the emergence of vascular malformations. Specifically, we propose to identify variants that function collaboratively with RAS activation to promote abnormal growth and aberrant organization of endothelial cells and to seek novel therapeutic drugs to treat vascular malformations. This research is directly relevant to the NIH mission: to reduce illness and disability.

PI_NAMEs: IRUELA-ARISPE, M. LUISA  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Affect;Alleles;Arteriovenous malformation;Biological;Biological Assay;Blood capillaries;Blood Vessels;Brain;brain arteriovenous malformations;Candidate Disease Gene;Cells;Clinic;Clinical;cohort;Collaborations;combinatorial;Combinatorics;Complex;Data;Development;Diagnosis;disability;Disease;DNA Sequence Alteration;Ear;Early Diagnosis;Eligibility Determination;Endothelial Cells;Endothelium;exhaust;exome;experimental study;Genes;Genetic;Genetic Epistasis;genetic linkage analysis;Genetic Screening;Germ-Line Mutation;Goals;Growth;Hemorrhage;high risk;Homeostasis;Human;improved;In Vitro;in vivo;individualized medicine;Intercellular Junctions;Intervention;Lesion;lifetime risk;malformation;Mission;Molecular;molecular subtypes;Molecular Target;Morbidity - disease rate;mortality;mouse model;mTOR Inhibitor;Mus;Mutagenesis;Mutate;Mutation;novel;novel therapeutics;Null Lymphocytes;Operative Surgical Procedures;Organ;Pathologic;Pathology;Pathway interactions;patient stratification;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;phosphoproteomics;PI3K/AKT;PIK3CG gene;Procedures;Process;PTEN gene;Quality of life;Research;reverse genetics;Risk;Risk Assessment;Seizures;Signal Pathway;Signal Transduction;Sirolimus;Sleeping Beauty;Somatic Mutation;Stroke;stroke risk;synergism;System;Testing;Therapeutic;Tissue Donors;Transposase;United States National Institutes of Health;Validation;Variant

PROJECT_TITLE: Endothelial RASOpathies and Vascular Malformations

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Hematology;Nutrition;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CLEMSON

ORG_DEPT: GENETICS

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project Narrative The proposed research will establish the relationship between blood, liver, and skeletal muscle levels of iron, the onset of cellular declines, and the mechanistic pathway(s) that lead to a reduction in the work capacity across iron levels. The work is relevant to public health and the NIH mission because iron deficiency is the most common micronutrient deficiency in the world, is common in life stages including women of reproductive age and children, and may contribute to skeletal muscle impairment before iron biomarkers are compromised.

PI_NAMEs: ANHOLT, ROBERT R. H;MACKAY, TRUDY F. (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: 5 year old;Affect;Age;Anemia;Biological Markers;Blood;Bone Marrow;Categories;Cell Physiology;Cell Respiration;Cells;Centers of Research Excellence;Child;Clinical;cognitive development;Complex;Data;Diet;Dietary Iron;Female;Ferritin;food insecurity;functional decline;Hemoglobin;Hemoglobin concentration result;Human;Human Genetics;Impairment;Individual;Infant;innovation;Intake;Intervention;Iron;iron deficiency;Iron deficiency anemia;Life;Liver;Maintenance;micronutrient deficiency;Mission;Mitochondria;Modeling;mouse model;Mus;Myoblasts;National Health and Nutrition Examination Survey;Nutrient;nutrition;Nutritional;Oxidative Phosphorylation;oxygen transport;Pathway interactions;poor health outcome;Population;Predisposition;Production;programs;Public Health;reproductive;Research;Sex Differences;Skeletal Muscle;Specificity;Testing;TFRC gene;Tissues;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: COBRE in Human Genetics


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE There are over 7 million homebound older adults with serious illness who suffer from untreated symptoms such as pain, shortness of breath, or symptoms of dementia (e.g., agitation and sleep disturbance), and their caregivers are often not empowered to assess symptoms or know when or how to reach out to primary care teams for assistance. The objective of this proposal is to empower caregivers in symptom assessment and prevent symptom crises by co-designing and pilot testing a digital symptom assessment tool with caregivers and primary care teams of homebound, low-income older adults with serious illness. Findings from this study will inform the design and implementation of digital symptom assessment tools and other novel digital interventions to improve the care of homebound older adults with serious illness and their caregivers.

PI_NAMEs: NOURI, SARAH  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;Advance Care Planning;Aging;Agitation;Alzheimer's Disease;Alzheimer's disease related dementia;Assessment tool;Behavior;behavior change wheel;California;care systems;career;career development;Caregiver support;Caregivers;Caring;chronic care model;Clinical;Communities;community advisory board;Consolidated Framework for Implementation Research;Dementia;design;Development;Development Plans;Diabetes Mellitus;digital;digital health;digital intervention;digital solutions;digital tool;disability;Distress;economic disparity;Emergency department visit;empowerment;Enrollment;Ensure;Equity;ethnic minority;Ethnic Origin;Evaluation;Event;Exclusion;experience;Family;feasibility testing;feasibility trial;Focus Groups;follow-up;Funding;Goals;handheld mobile device;health equity;Home;Impaired cognition;implementation science;implementation strategy;improved;Instruction;Intervention;intervention mapping;Interview;Leadership;Learning;literacy;Low income;Malignant Neoplasms;marginalization;Measures;Medicaid;Medicaid eligibility;medical specialties;member;Mentors;Methods;Modeling;Monitor;Motivation;neuropsychiatric symptom;novel;Nurses;older adult;Outcome;Pain;Palliative Care;Palliative Medicine;Paper;Participant;Persons;pilot test;Population;Population Heterogeneity;prevent;Primary Care;primary care clinic;primary care patient;primary care setting;primary care team;professor;Qualitative Methods;Quality of Care;Race;racial minority;Randomized;randomized trial;Randomized, Controlled Trials;reduce symptoms;remote patient monitoring;Reporting;Research;Research Personnel;Resources;safety net;San Francisco;Service delivery model;Services;Severities;Shortness of Breath;skills;Sleep disturbances;smartphone application;socioeconomics;Spanish;Symptom Burden;symptom management;symptomatic improvement;Symptoms;telehealth;Testing;therapy development;Time;tool;Training;treatment as usual;trial design;United States National Institutes of Health;Universities;usability;user centered design;web app;web site;Woman;Work

PROJECT_TITLE: CARES: A Caregiver-Facing Digital Symptom Assessment Tool for Marginalized Older Adults with Serious Illness

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-6 (M1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Community agencies that provide support to socioeconomically disadvantaged communities have tremendous potential to help their clients who use tobacco get help in quitting tobacco. Pragmatic research can help identify strategies community agencies can use to connect their clients with evidence-based tobacco use treatments. This project will first refine and pilot test promising strategies designed to engage social service workers and clients in tobacco quitline referral, and then will evaluate these strategies in a randomized controlled trial.

PI_NAMEs: MCCARTHY, DANIELLE ERIN (contact)

PROGRAM_OFFICER_NAME: NORTON, WYNNE E

PROJECT_TERMS: Address;Adoption;Adult;Affect;American;arm;Automobile Driving;cancer prevention;cigarette smoking;Client;Clinical Trials;cluster randomized design;collaborative approach;combustible cigarette;Communities;community organizations;Community Services;cost;Cost Analysis;cost effectiveness;County;Data;Death Rate;design;Disadvantaged;Disparity population;Economically Deprived Population;Education;Effectiveness;effectiveness/implementation hybrid;Equity;evidence base;experimental arm;Exploration, Preparation, Implementation, and Sustainment;falls;follow-up;Food;Health Promotion;implementation evaluation;implementation intervention;implementation measures;implementation outcomes;implementation process;implementation strategy;incentive strategies;Incentives;inclusion criteria;Inequity;innovation;International;Intervention;Low income;Maintenance;Malignant Neoplasms;Measures;Mental disorders;Methods;Modeling;Morbidity - disease rate;mortality;Motivation;neighborhood disadvantage;novel;Outcome;Patients;Personal Satisfaction;Persons;Phase;pilot test;Population;pragmatic study;pragmatic trial;Prevalence;prevent;primary outcome;Procedures;Process;programs;quitline;Randomized;Randomized, Controlled Trials;Records;Research;Research Methodology;Research Personnel;Resource-limited setting;Resources;response;safety net;Service setting;Services;Site;Smoke;Smoking;smoking abstinence;Smoking treatment;social;social engagement;Social Work;socioeconomic disadvantage;socioeconomic disparity;Speed;Structure;substance use;success;Testing;theories;timeline;Tobacco;tobacco cessation intervention;tobacco control;Tobacco use;Tobacco Use Cessation;tool;Training;treatment as usual;Wisconsin

PROJECT_TITLE: Using a Pragmatic Randomized Rollout Trial to Evaluate Implementation Strategies to Promote Smoking Treatment and Cancer Prevention for Salvation Army Clients

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ORG_CITY: ATLANTA

ORG_DEPT: NEUROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Alzheimer’s Disease (AD) is a debilitating neurodegenerative disorder affecting more than 40 million people world-wide but for which we lack drugs to slow disease progression. AD drug development is limited by our poor understanding of the biology that cause this disease. Here we take an open approach to catalyze drug development by developing and openly distributing high-quality reagents for evaluation of a diverse set of next generation AD drug targets across the research community.

PI_NAMEs: CARTER, GREGORY W;EDWARDS, ALED M;GREENWOOD, ANNA K;LEVEY, ALLAN I (contact)

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Acceleration;Affect;Alzheimer's Disease;Alzheimer's disease model;Amyloid;Antibodies;Binding;Bioinformatics;Biological;Biological Assay;Biological Models;Biology;Biophysics;Brain;candidate validation;Cell Line;cell type;Cells;Chemicals;Communities;Computer Analysis;computerized tools;Data;Data Coordinating Center;data resource;design;Development;Disease;Disease Progression;drug development;drug discovery;Drug Targeting;effective therapy;Evaluation;experience;Experimental Models;Funding;Gene Targeting;Genetic;Goals;high risk;In Vitro;in vivo;induced pluripotent stem cell;Industry;Industry Collaboration;industry partner;Informatics;interest;Knowledge;Knowledge Portal;Learning;Legal patent;material transfer agreement;Medicine;Modality;multiple omics;Nature;Neurodegenerative Disorders;next generation;novel diagnostics;novel therapeutics;Nucleic Acids;open data;Pathway interactions;Persons;Pharmaceutical Preparations;pre-clinical;preclinical evaluation;Process;programs;protein purification;Proteins;public repository;public-private partnership;Reagent;Records;Research;Research Personnel;Resources;Risk;Role;Series;Set protein;structural genomics;tau Proteins;Testing;Therapeutic;therapeutic evaluation;Time;tool;Validation

PROJECT_TITLE: TREAT AD

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-1 (M1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

PHR: The narrative is attached in the Overall section.

PI_NAMEs: LEVEY, ALLAN I (contact)

PROJECT_TITLE: TREAT AD Admin


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PROJECT_TERMS: Adopted;Agreement;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapeutic;Autopsy;Awareness;Bioinformatics;Biological;Biological Assay;Biological Models;Biological Process;Cell Line;Cell model;Cell Physiology;cell type;Cells;Cellular Assay;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Data;data analysis pipeline;Data Set;data streams;Development;Disease;disease heterogeneity;Disease stratification;endophenotype;Engineering;Functional disorder;Funding;Generations;Genes;Genetic;Genetic Diseases;Genetic Risk;genome wide association study;genome-wide;Genomics;Goals;Grant;Human;Immune response;improved;induced pluripotent stem cell;lipid metabolism;Maps;Measures;Medical Genetics;Methods;Mitochondria;Molecular;Molecular Disease;Molecular Genetics;Multiomic Data;multiple omics;novel;Outcome;Pathway Analysis;Phase;Population;precision medicine;Process;Proteins;Proteomics;Resources;Risk;Sampling;Series;sex;System;Testing;Therapeutic;Transcript;transcriptomics;Update;Validation;Work

PROJECT_TITLE: TREAT AD Bioinformatics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative

PROJECT_TERMS: Affinity;Antibodies;Antigens;assay development;Binding;Bioinformatics;Biological Assay;Biology;Biomedical Research;Biophysics;Cell Line;Cells;Cellular biology;Chemicals;Chemistry;Collaborations;Communities;Complex;Consultations;cost effective;Data;Development;DNA;drug development;drug discovery;Drug Targeting;functional gain;Funding;Generations;Human;Immunofluorescence Immunologic;Immunoprecipitation;Industry;industry partner;inhibitor;insight;Knock-out;knockout gene;Knowledge;Libraries;Ligands;machine learning model;Mass Spectrum Analysis;novel;Performance;Pharmaceutical Chemistry;programs;protein function;protein purification;Protein Secretion;Proteins;Public Domains;public-private partnership;Publishing;Readability;Reagent;Recombinants;Research;Research Personnel;Resolution;Resources;RIPK2 gene;Role;screening;Side;small molecule;structural biology;structural genomics;Structure;Structure-Activity Relationship;Testing;Therapeutic;therapeutic evaluation;tool;virtual;virtual screening;Western Blotting

PROJECT_TITLE: TREAT AD Structural Biology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: abeta oligomer;Acceleration;Alzheimer's disease model;Animal Model;Antibodies;assay development;Autopsy;Bioinformatics;Biological;Biological Assay;Biological Products;Biology;Biophysics;Brain;California;Cell Line;Cell model;cell type;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Data Analyses;data preservation;design;Development;Disease;disease model;efficacy study;Engineering;Evaluation;experience;functional genomics;Gene Expression Profile;Genes;Genetic;genetic manipulation;Goals;high throughput screening;Human;human induced pluripotent stem cells;improved;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;innovation;insight;Institution;Modeling;multiple omics;Mus;Mutation;Names;Neurons;operation;Pathogenesis;Pharmaceutical Chemistry;pharmacokinetics and pharmacodynamics;Phenotype;Plasma;Private Sector;protein expression;Proteins;Public Sector;Reagent;Role;San Francisco;screening;Series;Small Interfering RNA;structural biology;structural genomics;Structure;System;targeted treatment;tau aggregation;technology platform;Testing;The Jackson Laboratory;Therapeutic;tool;Universities;Validation;virtual;virtual screening;Washington

PROJECT_TITLE: TREAT AD Assay Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Machine Learning and Artificial Intelligence;Neurodegenerative

PROJECT_TERMS: Achievement;Affinity;Alzheimer's disease model;analog;Antibodies;Binding;Biochemical;Biological;Biological Assay;Biological Models;Biophysics;Brain;Bromodomain;Cells;chemical release;Chemicals;Clinical Trials;Communities;Complement;Data;Deposition;Development;Disease;DNA;Drug Targeting;Enzymes;Foundations;In Vitro;in vivo;Intervention;Ion Channel;iterative design;Knowledge;Libraries;Machine Learning;member;model building;Modeling;novel;Pathway interactions;Penetration;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Plasma;programs;Property;protein purification;Proteins;Proteome;Public Domains;public-private partnership;Publications;Reagent;receptor;repository;Role;Sampling;screening;small molecule;structural biology;structural genomics;Structure;Structure-Activity Relationship;Testing;Therapeutic;Time;transcription factor;Work

PROJECT_TITLE: TREAT AD Medicinal Chemistry Core


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  Although the clinical high risk for psychosis (CHR) criteria offer an important public health target and opportunity to prevent psychotic disorders, drug development tools (DDTs) need to be tested for use in Phase 2 clinical trials before new medications can enter clinical practice. The 15 US sites of the Psychosis Risk Outcomes Compound Assessment Network (ProCAN) will test DDTs from the Accelerating Medicines Partnership® Schizophrenia Observational Study in one or two 16-week proof-of-principle clinical trials. Study drug signal on outcome measures, biomarkers, and safety will also be evaluated; in addition, in partnership with the Clinical Trials Data Processing, Analysis, and Coordinating Center, ProCAN will deliver outcome and biomarker metrics that are analyzable to detect drug signal upon trial completion.

PI_NAMEs: BEARDEN, CARRIE E;CHO, YOUNGSUN T;KANE, JOHN M;WOODS, SCOTT W (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Acceleration;Address;Adolescent and Young Adult;adolescent patient;arm;Articulation;attenuated psychosis syndrome;behavioral health;Biological;Biological Markers;biomarker identification;Budgets;Clinic;Clinical;Clinical Drug Development;clinical heterogeneity;clinical high risk for psychosis;clinical outcome measures;clinical practice;clinical trial participant;Clinical Trials;Cognitive;Communities;computerized data processing;Data;data archive;Detection;Development;Diffusion Magnetic Resonance Imaging;digital;Digital biomarker;Dose;drug development;drug mechanism;drug testing;Electroencephalography;Eligibility Determination;experience;Family;follow-up;Foundations;Functional impairment;Functional Magnetic Resonance Imaging;Funding;gamma-Aminobutyric Acid;Glutamates;Goals;high risk;Hydrocortisone;Individual;Infrastructure;insight;Internet;Intervention;Left;Liquid substance;Medicine;Mental Health;Meta-Analysis;Muscarinics;National Institute of Mental Health;Natural Language Processing;neurobiological mechanism;novel marker;novel therapeutics;Observational Study;Outcome;Outcome Measure;Participant;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phase;Phase II Clinical Trials;Placebos;polygenic risk score;Population;precision medicine;predict clinical outcome;Prevalence;prevent;Prevention;Privatization;Probability;Process;Psychiatric therapeutic procedure;Psychoses;psychosis risk;Psychotherapy;Psychotic Disorders;Public Health;Recording of previous events;recruit;Research;Research Personnel;response;Rest;Risk;Safety;Schizophrenia;Services;Severities;Signal Transduction;Site;Specific qualifier value;symptomatic improvement;Testing;Time;timeline;tool;tool development;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Youth

PROJECT_TITLE: ProCAN: Psychosis Risk Outcomes Compound Assessment Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (04)]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Inflammatory Bowel Disease;Microbiome;Nutrition;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This cross-over study will test a culturally-tailored diet for Hispanic/Latino (H/L) patients with ulcerative colitis and determine predictors of response to diet therapy, including stool microbiome composition and polyunsaturated fatty acid (PUFA) metabolism. By the end of this study, we seek to gain a better understanding of the role of individual patient factors as biomarkers of response to diet and to develop a blueprint for the development of anti-inflammatory culturally tailored diets for patients with inflammatory bowel disease (IBD). The findings from this study may guide food-based recommendations based on cultural background, stool microbiome makeup, and an individual’s capacity for PUFA metabolism.

PI_NAMEs: DAMAS, ORIANA MAZORRA (contact)

PROJECT_TERMS: Adherence;Adoption;Anti-Inflammatory Agents;Bacteria;Biochemical;Biological Markers;Blood;Blood specimen;Clinical;Clinical Trials;cohort;Colitis;Consumption;Controlled Clinical Trials;Cross-Over Studies;Crossover Design;Cultural Backgrounds;Data;design;Development;Diet;Diet therapy;dietary;Dietary Intervention;Disease;Disease remission;efficacy evaluation;Enzymes;ethnic diversity;evidence base;experience;Fatty acid glycerol esters;fatty acid metabolism;fecal microbiome;Feces;Fiber;Flare;Food;Food Preferences;Fruit;Future;Genes;Genetic;Genetic Polymorphism;Genetic Research;genetic variant;Genetic Variation;genome sequencing;Goals;good diet;gut inflammation;gut microbiome;high-fat/low-fiber diet;Hispanic;Immune;improved;indexing;Individual;individual patient;Inflammation;Inflammatory Bowel Diseases;innovation;Intake;Intervention;Latino;Latino Population;Leukocyte L1 Antigen Complex;lipid metabolism;Manihot;Measures;Mediating;Mediator;Metabolic Pathway;metabolomics;metagenomic sequencing;microbiome;microbiome composition;microbiome signature;microbiota;microbiota composition;microbiota metabolites;Modeling;N-3 polyunsaturated fatty acid;nutrient metabolism;nutritional genomics;Pathway interactions;Patients;personalized predictions;Pilot Projects;Placebos;Play;Polyunsaturated Fatty Acids;Population;precision nutrition;predicting response;predictive marker;primary outcome;Proteus;prudent diet;Randomized;Recommendation;Recurrent disease;Relapse;relapse risk;Research;responders and non-responders;response;response biomarker;Risk;Role;Serum;Symptoms;Testing;Tissues;Ulcerative Colitis;Variant;Vegetables;western diet;whole genome;Work;Yucca

PROJECT_TITLE: A culturally tailored anti-inflammatory diet for Hispanic patients with ulcerative colitis

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Emergency Care;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE – Skipping the hospital: Acute hospital care at home for people living with dementia The harms of hospitalization are magnified for people living with dementia (PLWD) such that they have 5 times the odds of suffering an adverse event; acute hospital care at home (AHCaH) was specifically developed as a substitutive delivery model to avoid these common harms while receiving the care that they need at home and is now operating in 37 states. Few AHCaH efforts specifically target PLWD, and we propose a year-long enrollment 3-part model: 1) in-home serious illness conversation and caregiver resourcing; 2) video and in- home acute illness evaluation on demand with in-home mobile integrated health paramedics, remote physicians, and home health aides; and 3) AHCaH as needed with additional resources for PLWD including additional home health aide care and delirium prevention measures. Our overarching aim is to implement and evaluate (NIH Stage III) a year-long pre-enrolled AHCaH pathway specifically for PLWD that will serve as a national model and will represent a paradigm shift in how hospital-level care is delivered to PLWD.

PI_NAMEs: LEVINE, DAVID MICHAEL (contact)

PROJECT_TERMS: Accident and Emergency department;Acquired disability;Acute;acute care;Admission activity;Adverse event;Affect;Alzheimer's disease related dementia;American;Asthma;Biometry;Bypass;care costs;Caregiver Burden;Caregiver support;Caregivers;Caring;Cause of Death;Chronic Obstructive Pulmonary Disease;Control Locus;cost;decubitus ulcer;Delirium;Dementia;Diagnostic;Discipline of Nursing;Enrollment;Environment;Evaluation;experience;falls;Family;Family Caregiver;functional status;Goals;hazard;Health;health related quality of life;Heart failure;Home;Home environment;Home Health Aides;hospital care;hospital readmission;Hospitalization;Hospitals;improved;Infection;Interview;Intravenous;Learning;Methods;Modeling;Monitor;mortality;Occupational Therapy;older adult;Outcome;pandemic disease;Paramedical Personnel;Pathway interactions;patient home care;Patients;Persons;Pharmaceutical Preparations;Physical activity;Physical therapy;Physicians;Population;Prevention Measures;Quality of life;Quantitative Evaluations;Randomized;Randomized, Controlled Trials;Recurrence;Regulatory Pathway;remote assessment;Resources;Respiratory Therapy;response;Risk;Safety;Services;Sleep;Societies;Structure;Surveys;Syndrome;Time;treatment as usual;United States National Institutes of Health;Visit;Visiting Nurse

PROJECT_TITLE: Skipping the hospital: acute hospital care at home for people living with dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-S (M1)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative: Fetal alcohol spectrum disorder (FASD) is a prevalent group of conditions may involve mental deficiencies from fetal alcohol exposure that typically persist for a lifetime. Vinpocetine is a pharmacological agent that improves neuronal plasticity and has been shown to improve cognitive deficits in multiple animal models of FASD. The proposed studies are designed to determine the effective dose of vinpocetine and to obtain preliminary data on safety and efficacy of vinpocetine for treatment of FASD in humans.

PI_NAMEs: KABLE, JULIE A;MEADOR, KIMFORD J (contact);MEDINA, ALEXANDRE ESTEVES

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Adolescent;Adult;alcohol effect;alcohol exposure;Animal Model;Animals;Behavior;Behavioral;Blood;Brain;Child;Clinical Trials;Cognition;Cognitive;Cognitive deficits;cognitive enhancement;Data;data management;data tools;design;Development;disease model;dosage;Dose;Drug Kinetics;Early Intervention;efficacy evaluation;experimental study;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Future;Human;human model;human study;Impaired cognition;Impairment;improved;inhibitor;Investigation;Manuals;Mediation;Medical;Memory;Mental deficiency;Modeling;Neuronal Plasticity;Neuropsychology;operation;Oral;Outcome;Persons;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;phase 1 study;phase 2 study;phase III trial;Phosphodiesterase Inhibitors;Plasma;prenatal exposure;Problem behavior;Procedures;Protocols documentation;randomized, clinical trials;Research;Research Design;response;Safety;safety assessment;Series;service intervention;side effect;Time;vinpocetine;volunteer

PROJECT_TITLE: Vinpocetine Mediation of Prior Fetal Alcohol Exposure

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ORG_CITY: Newark

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: The BMP2 signaling pathway intersects with other crucial signaling pathways, such as Wnt, Hedgehog, Notch, Fibroblast Growth Factor (FGF), and Parathyroid Hormone (PTH) (1-5), making it a key regulator for bone formation and maintenance. BMP2 function is crucial for osteogenesis and fracture repair and aberrant BMP2 signaling is reported in patients diagnosed with Osteoprosis.

PI_NAMEs: ELLIOTT, DAWN M (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Affect;Aging;aging mechanism;American;Animal Model;Automobile Driving;Binding;Biology;BMP2 gene;bone;Bone Density;Bone Diseases;bone fracture repair;bone mass;Bone structure;C57BL/6 Mouse;Calcium;casein kinase II;Caveolae;Cell Culture Techniques;Cell membrane;Cell surface;Cells;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;comparison control;Consumption;cost;Data;design;Diagnosis;Down-Regulation;Emotional;Endocytosis;Erinaceidae;Estrogens;Exhibits;femur head;Fibroblast Growth Factor;Fracture;Goals;Growth Factor;Hip Fractures;homeodomain;Impairment;Incidence;indexing;Injections;Interruption;Knock-out;Link;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Medical Care Costs;Mesenchymal Stem Cells;mineralization;Modeling;Molecular;mortality;Mus;notch protein;Nutrient;old mice;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Ovary;overexpression;Pathway interactions;patient response;Patients;Peptides;Persons;Phosphorylation;Physiologic calcification;Postmenopause;Pregnancy;prevent;PTH gene;Quality of life;receptor;receptor recycling;Recycling;Reporting;response;Risk;Role;side effect;Signal Induction;Signal Pathway;Signal Transduction;Skeleton;Small Interfering RNA;Therapeutic;Time;type IA bone morphogenetic protein receptor;uptake;Well in self;Woman;women patients;Women's Health

PROJECT_TITLE: Aberrant BMP2 signaling during aging and its impact on Women Health


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Pediatric;Prevention;Suicide;Suicide Prevention

ORG_CITY: MIAMI

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: Project Narrative This project is designed to test a brief therapy to reduce suicidal ideation among a diverse sample of youths ages 12 to 17 who experience anxiety or depression. The goal of the study is to conduct two clinical trials testing whether this therapy reduces suicidal ideation and related beliefs that one is a burden on others. This project will contribute to the field by potentially showing evidence supportive of a brief strategy to reduce suicidal ideation in a way that can be readily understood and used by mental health providers in the community.

PI_NAMEs: BUITRON, VICTOR  (contact);PETTIT, JEREMY W

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: Acute;Address;Adherence;Adjuvant;Aftercare;Age;Anxiety;arm;Behavioral;Belief;brief intervention;Cessation of life;Client;Clinic;Clinical;Clinical Trials;Cognitive;Cognitive Therapy;combination intervention strategy;Communities;Complement;cost;cost efficient;Data;design;Emergency department visit;Ethnic Origin;Etiology;Evaluation;experience;Feeling suicidal;Female;Goals;Health Personnel;High School Student;Hospitalization;Human Resources;Impairment;Inpatients;Intensive Care;Intervention;Intervention Trial;Intuition;Law Enforcement;Life;Link;male;Manuals;Measurement;Measures;Mental Depression;Mental Health;Methods;multi-component intervention;National Institute of Mental Health;novel;Outpatients;Parents;Participant;Patient Self-Report;Phase;Preparation;Protocols documentation;psychosocial;Quasi-experiment;racial diversity;Randomized;Randomized, Controlled Trials;recruit;reducing suicide;Reporting;Resources;Risk Factors;Risk Management;Safety;Sampling;satisfaction;Schools;Services;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Testing;theories;therapeutic target;Time;Training;treatment as usual;treatment comparison;Treatment Protocols;Universities;Validation;Waiting Lists;Work;Youth

PROJECT_TITLE: Evaluation of a brief, scalable module to mitigate suicidal ideation among youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (04)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;HIV/AIDS;Hematology;Hodgkin's Disease;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The risk of developing classic Hodgkin lymphoma has increased in persons living with HIV whose HIV is well- controlled by combination anti-retroviral treatment. Our proposal investigates how benign and classic Hodgkin lymphoma lymph node samples, with respect to RNA and protein expression in the non-malignant cells in the tissue samples, differ from those in people without HIV. Our proposed study will eventually help in reducing the risk of developing classic Hodgkin lymphoma in persons living with HIV.

PI_NAMEs: NARESH, KIKKERI  (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: Address;Age;Aging;Antibodies;antiretroviral therapy;B lymphoid malignancy;B-Lymphocytes;Bar Codes;Benign;cancer cell;Cancer Center;Cancer Patient;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Communication;Cells;Cellularity;Classification;cohort;cost;Development;differential expression;DNA;DNA Methylation;editorial;epigenetic aging;Epigenetic Process;FOXP3 gene;Gene Expression;General Population;Genes;Genetic Transcription;Hematologic Neoplasms;Histologic;HIV;HIV/AIDS;Hodgkin Disease;Human Herpesvirus 4;Hyperplasia;IL3RA gene;Immune;Immune response;Immunocompetent;immunodeficiency;Immunohistochemistry;In Situ;In Situ Hybridization;Incidence;Individual;innovation;interdisciplinary approach;interest;International;Investigation;Leukocytes;Life Expectancy;lymph node biopsy;lymph nodes;lymphadenopathy;Lymphoma;Lymphoproliferative Disorders;Malignant lymphoid neoplasm;Malignant Neoplasms;molecular imaging;nano-string;NCAM1 gene;neoplastic cell;Non-Hodgkin's Lymphoma;Non-Malignant;Paraffin;Pathogenesis;Pathology;Patients;Persons;Play;Principal Investigator;protein expression;Proteins;Relative Risks;Risk;Risk Reduction;RNA;Role;Sampling;Stromal Cells;System;Systems Analysis;Technology;Tissue Microarray;tissue resource;Tissue Sample;Tissues;transcriptome;transcriptome sequencing;transcriptomics;tumor;tumor-immune system interactions;United States;Universities;Washington;World Health Organization

PROJECT_TITLE: Understanding the pathogenesis of classic Hodgkin lymphoma in persons living with HIV through conventional and spatial transcriptomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (M1)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Nutrition;Pediatric;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Development of an integrated informatics and data infrastructure for women’s precision health Project Narrative The proposed program will leverage past women’s health cohort and intervention study data to develop an integrated environment for storage, management, integration, and analysis of metabolomics, genomics, proteomics, microbiome, clinical biochemical, and patient personal phenotypic data, for precision health research. The integrative tools will include a research database, software, and cloud-based infrastructure designed to facilitate machine learning and AI data analytics; a dashboard to support monitoring, measuring, analyzing, and visualizing data - providing improved data interfaces and interoperability workflows to support research into the relations between women’s genetics, environment and health.

PI_NAMEs: CORNETT, LAWRENCE E (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Administrative Supplement;Adopted;adverse pregnancy outcome;Age;Apache;Arkansas;Artificial Intelligence;artificial intelligence algorithm;Biochemical;biomarker discovery;Biomedical Research;Child;Child Development;Child Health;Child Nutrition;Clinical;Clinical Research;cloud based;Cloud Computing;Cohort Studies;Computer software;computerized data processing;Conceptions;dashboard;Data;Data Analyses;Data Analytics;data dashboard;data infrastructure;data integration;data sharing;data visualization;Databases;deep learning;design;Development;Diet and Nutrition;Dietary Factors;Dietary intake;Dimensions;Disease;disorder prevention;Educational workshop;Ensure;Environment;Ethnic Origin;evidence base;fundamental research;Funding;Future;Genetic;Genomics;Goals;Health;health goals;Human Development;Improve Access;improved;individualized medicine;Informatics;informatics infrastructure;Infrastructure;infrastructure development;innovation;interoperability;Intervention Studies;Knowledge;knowledgebase;Lactation;Learning;lifestyle factors;Machine Learning;machine learning algorithm;maternal outcome;Measures;Medical;Medical History;metabolome;metabolomics;Methods;microbiome;Mission;Modeling;Monitor;Mothers;multidisciplinary;Multiomic Data;multiple omics;Online Systems;Outcome;Patients;phenotypic data;Precision Health;precision nutrition;Pregnancy;pregnant;programs;Proteomics;Race;Recording of previous events;Research;Research Institute;Research Personnel;research study;Research Support;Resources;scaffold;Science;Series;sex;Socioeconomic Status;Statistical Methods;Strategic Planning;Students;Time;tool;Training;translational study;United States Department of Agriculture;United States National Institutes of Health;Universities;Vision;Visualization;Woman;Women's Health

PROJECT_TITLE: Partnerships for Biomedical Research in Arkansas


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Climate-Related Exposures and Conditions;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_DEPT: DERMATOLOGY

PHR: PROJECT NARRATIVE There is a need for interventions that can mitigate mustard induced chemical burns and resolve secondary immune reactions. The strategy couples a methodic algorithm in three successive models with robust clinical endpoints to down select and deliver an optimized Synthetic Melanin Particle (SMP) lead drug for healing the skin. These studies will enhance our understanding of how to effectively treat skin damage after exposure to mustard agents.

PI_NAMEs: GIANNESCHI, NATHAN CLAUDE;LU, KURT  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Acceleration;Acute;Address;Algorithms;Amines;Animals;Antioxidants;Apoptosis;Area;Basement membrane;Benchmarking;Biological;Biological Markers;biomaterial compatibility;Biomimetics;Bulla;Caring;CCL20 gene;Cells;Charge;Chemical Burns;Chemicals;Chemotactic Factors;Cicatrix;Clinical;clinical translation;Clinical Trials;clinically relevant;Collaborations;Complex;Coupled;Couples;Cutaneous;cytokine;Cytokine Signaling;Data;Data Set;Debridement;Dermal;Dermis;Development;Dose;Drug vehicle;Elements;Engineering;Epithelium;Erythema;eumelanin;Evaluation;Excipients;experience;Experimental Models;exposed human population;Exposure to;Family suidae;FDA approved;Fibrosis;FOXP3 gene;fungus;Gamma Rays;Gelatinase B;healing;Histologic;Histology;Human;human subject;Hydrocarbons;hydrophilicity;Hydrophobic Surfaces;Hydrophobicity;Hypersensitivity skin testing;ICAM1 gene;IL2RA gene;IL8 gene;Immune;immune cell infiltrate;immunoreaction;Impaired wound healing;in vivo;in vivo evaluation;Individual;Inflammation;Inflammatory;Injury;instrument;Interleukin-10;Intervention;keratinocyte;Lead;lead candidate;Length;Libraries;lipophilicity;Lymphoid;Macrophage;MAPK3 gene;Measures;Mechlorethamine;Melanins;migration;mimetics;Modeling;Modification;monocyte;mouse model;Mus;Mustard;Mustard Agent;Mustard Gas;Myelogenous;Nature;Necrosis;oncostatin M;Pain;particle;Pathology;Pharmaceutical Preparations;Phase;Phosphorylation;polymerization;Polymers;Population;porcine model;Positioning Attribute;prevent;Process;Publishing;Radial;Radiation induced damage;re-epithelialization;Reaction;Reactive Oxygen Species;Readiness;Recovery;Regenerative Medicine;Regulatory T-Lymphocyte;repaired;reparative healing;Research Contracts;Resolution;response;restoration;Schedule;Selection Criteria;Shapes;Silver;Site;Skin;skin barrier;skin burn;skin circulation;skin damage;skin healing;Skin injury;Skin Tissue;Sterile coverings;Stratum corneum;Sunburn;Superoxide Dismutase;Surface;T-Lymphocyte;Technology;Testing;therapeutic development;Thick;Time;tissue injury;Tissues;Topical application;Toxic effect;Toxin;Transforming Growth Factor beta;Ultraviolet Rays;Universities;UV protection;Vesicants;wound;wound healing

PROJECT_TITLE: Synthetic Melanin for Accelerating Wound Repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-P (50)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: LUBBOCK

ORG_NAME: TEXAS TECH UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative Tumor stem cells are the major players involved in tumor metastasis, immune evasion, therapeutic resistance, and relapse and therefore are closely related to cancer deaths. In the proposed R03 application, we aim to study a new mechanism on how tumor stem cells mask immune macrophage activation and metabolism via actively transferring their malfunctional mitochondria into macrophages. Successful completion of the project will determine a way forward in the development of new therapeutic strategies against tumor stem cells and tumor macrophages and is of paramount importance for cancer community.

PI_NAMEs: CHEN, KUAN-HUI  (contact)

PROJECT_TERMS: 4T1;anti-cancer research;ARG2 gene;arginase;Arginine;Awareness;Breast Cancer Cell;cancer cell;cancer initiation;cancer stem cell;cancer type;Cell Cycle Regulation;Cell Death;Cell Proliferation;Cells;Cessation of life;Coculture Techniques;Communities;Competence;Dependence;Development;dichlorofluorescin;Disease;fatty acid oxidation;Female;Female Breast Carcinoma;Flow Cytometry;Fluorescence;Fluorescent Dyes;Genus Hippocampus;Germ-Line Mutation;Granulocyte-Macrophage Colony-Stimulating Factor;Human;IL4 gene;Immune;Immune Evasion;Immune response;immunoregulation;inhibitor;insight;interest;Invaded;Knowledge;Label;Link;Literature;Macrophage;Macrophage Activation;male;Malignant Breast Neoplasm;Malignant Neoplasms;Masks;Mediating;Metabolic;Metabolic Pathway;Metabolism;migration;Mitochondria;Mitochondrial Diseases;mitochondrial metabolism;Modification;Mus;Neoplasm Metastasis;nonbinary;novel therapeutic intervention;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;Palmitates;Phagocytosis;Play;Population;Production;Reactive Oxygen Species;Regulation;Relapse;Reproducibility;Research;response;Role;Scientist;sex;Sex Differences;Somatic Mutation;Stains;stemness;Stromal Cells;Surface;Testing;Therapeutic Intervention;therapeutically effective;therapy resistant;tumor;tumor initiation;tumor microenvironment;Tumor Promotion;Tumor Stem Cells;Tumor-associated macrophages;tumorigenesis;uptake;Urea;Work

PROJECT_TITLE: Tumor stem cell initiated mitochondrial transfer


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

PHR: PROJECT NARRATIVE (Public Health Relevance) Significant expense and effort by groups of scientists around the world has identified regions of the human genome that are associated with the genetic risk for various forms of cardiovascular disease, including coronary artery disease. Additional research is required to understand the specific genes involved, and how they work to contribute to the disease process. Such information will allow for better risk assessment and the development of better therapeutics for these diseases.

PI_NAMEs: QUERTERMOUS, THOMAS  (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Address;Affect;Algorithms;Animals;Apolipoprotein E;Atherosclerosis;Binding;Biological Assay;Blood Vessels;Cardiovascular Diseases;causal variant;Cell Lineage;cell type;Cells;Chromatin;Complex;Coronary Arteriosclerosis;Coronary artery;coronary lesion;CRISPR interference;Data;data modeling;Development;Disease;disease model;Disease Progression;disorder risk;Disparate;Enhancers;epigenome editing;epigenomics;Etiology;Event;Fibroblasts;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Diseases;Genetic Models;Genetic Risk;genome wide association study;Goals;Heart;Heart Transplantation;Human;human disease;Human Genome;In Vitro;in vivo;Lesion;Link;Maps;Medial;Mediating;Methods;Modeling;Molecular;mouse genetics;mouse model;Multiomic Data;multiple omics;Mus;Osteogenesis;Pathway interactions;Phenotype;Process;programs;public health relevance;Regulatory Element;Regulon;Research;response;Risk;Risk Assessment;RNA;Role;Sampling;Scientist;Severities;Severity of illness;Signaling Molecule;single cell genomics;single-cell RNA sequencing;Smooth Muscle;Smooth Muscle Myocytes;Specific qualifier value;targeted treatment;Therapeutic;Time;Trans-Activators;transcription factor;transcriptomics;Transplant Recipients;Variant;Vascular calcification;Vascular Diseases;Vascular Smooth Muscle;vascular stress;Work;XCL1 gene

PROJECT_TITLE: Gene regulatory networks controlling smooth muscle phenotype and vasculardisease risk

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Biotechnology;Hematology;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK BLOOD CENTER

ORG_STATE: NY

PHR: Equity of access to soon to be approved gene therapies for sickle cell disease is hampered by the costs and logistics of collecting sufficient bone marrow stem cells for gene modification and infectious and transfusion- related risks posed by the time until bone marrow recovery. Improving stem cell homing to and lodging in the bone marrow would mitigate these barriers. This proposal examines whether returning the immune and accessory cells that are removed with the gene modification process along with the stem cells will improve the stem cells’ bone marrow homing and lodgment.

PI_NAMEs: SHI, PATRICIA ANN (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: Address;Adult;Africa South of the Sahara;AMD3100;Antigen-Presenting Cells;arm;Autologous;Autologous Transplantation;Back;Biological Assay;Blood Component Removal;Blood Platelets;Bone Marrow;Bone Marrow Stem Cell;CD34 gene;cell motility;cell type;Cells;chemotherapy;Chimerism;conditioning;Cord Blood Hematopoietic stem cells;cost;cost effective;Country;effectiveness evaluation;Engraftment;Equity;experience;experimental arm;Exposure to;Freezing;Gene Expression;Gene Modified;gene therapy;graft vs host disease;hematopoietic engraftment;Hematopoietic Stem Cell Mobilization;Hematopoietic stem cells;Hemoglobinopathies;Home;Homing;Homologous Transplantation;Human;Immune;Immunodeficient Mouse;Immunophenotyping;improved;In Vitro;in vivo engraftment;Incubated;Infusion procedures;Intravenous infusion procedures;Left;Leukapheresis;leukemic transformation;Life;Logistics;low and middle-income countries;Lymphoid;Methods;migration;neutrophil;Patients;Persons;Physician Executives;post-transplant;pre-clinical;Process;programs;Quality of life;Recovery;Reporting;Research Personnel;Resources;Risk;Sickle Cell;Sickle Cell Anemia;Source;stem cell engraftment;stem cell genes;stem cells;Stress;T-Lymphocyte;Time;Transfusion;transplant centers;Transplantation;Umbilical Cord Blood;United States

PROJECT_TITLE: Evaluating accessory cells to improve homing and engraftment efficiency of CD34+ cells from sickle cell disease patients