NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_NAME: XLERATEHEALTH, LLC

PHR: Project Narrative Through this program, I-RED Southeast XLerator Network will develop a suite of experience-based entrepreneurship education products and commercialization education tools to address the needs of academic institutions and their faculty, researchers, innovators, and graduate/undergraduate students in the Southeast IDeA states region. The ultimate aim of these entrepreneurship education and training products is to foster the translation of promising biomedical discoveries and technologies from research laboratories into the creation of commercial products which both improve human health and promote economic growth. As a result, it will significantly enhance commercialization knowledge, mature the entrepreneurial ecosystem, identify more market-ready technologies and patents, see more startup entities formed, increase dilutive and non-dilutive funding to these entities, and accelerate the commercialization of biomedical and health tech innovations in the region – with the fundamental goal of positively impacting human health and patient’s lives.

PI_NAMEs: KRENTSEL, EUGENE ;MCCLURE, IAN D;SAUNDERS, ROBERT ;WILLMOT, JACQUELINE  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Acceleration;Address;Award;Biomedical Technology;Capital;Capital Financing;clinical practice;cohort;Collaborations;commercialization;Communication;design;Discipline;Economics;Ecosystem;Education;Effectiveness;Ensure;Entrepreneurship;Evaluation;experience;Faculty;Fostering;Fund Raising;Funding;Goals;Growth;Health;Health Technology;Healthcare;Human;improved;innovation;Institution;Investments;Kentucky;Knowledge;Laboratory Research;Lead;Legal patent;Licensing;Marketing;member;Monitor;National Institute of General Medical Sciences;new product development;Outcome;Participant;Patients;Phase;Pilot Projects;Positioning Attribute;Process;product development;Program Development;programs;prototype;Reporting;Research Personnel;Sales;Small Business Innovation Research Grant;Small Business Technology Transfer Research;social media;Structure;Students;success;Support System;Talents;Technology;Technology Transfer;Testing;tool;Training;Training and Education;Translations;undergraduate student;Universities;Validation

PROJECT_TITLE: I-RED Southeast XLerator Network


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: STONY BROOK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: NARRATIVE Fungal infections have dramatically increased during the last decade and new treatment strategies are needed. This proposal focuses on developing new antifungal compounds particularly against fluconazole-resistant Candida spp., but also against Cryptococcus spp. and Aspergillus spp., through the inhibition of the fungal sphingolipid pathway.

PI_NAMEs: DEL POETA, MAURIZIO  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: 3-Dimensional;Academia;Acceleration;Address;Animal Model;Animals;anti-fungal agents;Area;Aspergillosis;Aspergillus;Aspergillus fumigatus;Candida;Candidiasis;Cause of Death;Cell Physiology;Clinic;Clinical;clinical candidate;clinical efficacy;Collaborations;combinatorial;cross reactivity;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Development;Drug Design;drug development;drug discovery;Drug Kinetics;Drug Modelings;efficacy study;Evaluation;Exhibits;experience;Fluconazole resistance;Funding;fungicide;fungus;Generations;Goals;Human;Immunity;Immunocompromised Host;improved;In Vitro;in vivo;in vivo evaluation;Incubators;indexing;Individual;Industry;Infection;inhibitor;innovation;Intellectual Property;Investigation;Investigational Drugs;Lead;lead optimization;Libraries;Licensing;Life;Long Island;Medical;Mus;Mycoses;novel;novel therapeutic intervention;Pathogenesis;pathogenic fungus;Pathway interactions;Pharmaceutical Chemistry;pharmacologic;Pharmacologic Substance;Physicians;Physiology;Positioning Attribute;preclinical study;programs;Property;Quantitative Structure-Activity Relationship;Research;research and development;Resistance;Resistant candida;Safety;Scientist;screening;Secure;Series;Sphingolipids;Structure-Activity Relationship;Technology;Testing;Therapeutic;Toxic effect;Toxicology;Translating;United States Food and Drug Administration;Universities

PROJECT_TITLE: New antifungals targeting the synthesis of fungal sphingolipids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-N(02)]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: San Diego

ORG_NAME: ONCTERNAL THERAPEUTICS, INC.

ORG_STATE: CA

PHR: PROJECT NARRATIVE Kennedy’s disease is a progressive genetic neurodegenerative disease caused by an abnormal androgen receptor (AR) protein. There is currently no effective treatment available to slow, stop, or reverse the disease. Based on promising preclinical results obtained under a funded Phase 1 STTR grant, this Phase 2 SBIR grant application proposes to perform preclinical development studies with our androgen receptor antagonist and degrader ONCT-505 to destroy the AR protein as a potential therapeutic for Kennedy’s disease.

PI_NAMEs: KRISHNAN, RAJESH  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: advanced prostate cancer;Androgen Receptor;androgen sensitive;androgenic;Animal Model;antagonist;Applications Grants;Area;Award;Binding;Binding Proteins;Biological Assay;Biological Availability;Caco-2 Cells;Castration;Chemistry;Clinical;cross reactivity;Data;Development;Development Plans;Disease;Dose;drug candidate;drug development;Drug Kinetics;effective therapy;efficacy evaluation;efficacy study;Engineering;Evaluation;experience;experimental study;Follow-Up Studies;Formulation;Funding;Genetic;Grant;Hormone Receptor;In Vitro;in vivo;Industry;Investigational New Drug Application;Kennedy Syndrome;Knock-out;Manuals;manufacture;manufacturing process;Medical;medication safety;Metabolic;Mitochondria;motor neuron degeneration;multicatalytic endopeptidase complex;Musculoskeletal;Mutagenicity Tests;mutant;N-terminal;Neurodegenerative Disorders;Neurons;neurotoxic;novel therapeutics;Oral;Pathologic;Pathway interactions;patient - derived stem cells;Patients;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phase;phase I trial;Phenotype;Plasma Proteins;polyglutamine;pre-clinical;Pre-Clinical Model;pre-Investigational New Drug meeting;preclinical development;preclinical efficacy;Process;process optimization;Productivity;Property;protein degradation;Proteins;receptor;Receptor Activation;Receptor Aggregation;Records;Regulatory Affairs;Research;Rodent;Safety;safety study;scale up;Series;Signal Transduction;skeletal muscle wasting;Small Business Innovation Research Grant;Small Business Technology Transfer Research;small molecule therapeutics;Spinobulbar Muscular Atrophy;stem cell differentiation;Testosterone;Therapeutic;Therapeutic Agents;Toxic effect;Toxicokinetics;Toxicology;Transgenic Mice;Transgenic Model;Ubiquitin;United States Food and Drug Administration

PROJECT_TITLE: Preclinical development of ONCT-505, an Androgen Receptor Antagonist and Degrader, as new potential therapeutic for Kennedy's Disease


ADMINISTERING_IC: GM

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The rate of cellular turnover slows during aging, can be accelerated during injury and repair, and is precociously stimulated during carcinogenesis; but the mechanisms guiding turnover in living tissues is not well understood. The proposed studies will determine how the elimination of unfit cells by extrusion from epithelia stimulates the nearby stem cells to generate new cells and maintain overall cell numbers in the tissue. Discoveries arising from this work will provide new insights into mechanisms that can be harnessed to promote cellular replacement or prevent the unwanted addition of new cells.

PI_NAMEs: EISENHOFFER, GEORGE THOMAS (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Acceleration;Actomyosin;Address;Aging;Area;carcinogenesis;Cell Count;Cell Proliferation;Cells;Complex;Data;Epidermal Growth Factor Receptor;epigen;Epigenetic Process;Epithelial Cells;Epithelium;Event;Genetic Transcription;Goals;Homeostasis;Human;Immune;Individual;Inflammatory;injury and repair;Innate Immune System;insight;Knowledge;Ligands;Link;Lipids;Maintenance;mechanical properties;Molecular;novel strategies;Organism;Pathogenesis;prevent;Process;Proliferating;Recombinants;recruit;Regulation;response;Role;Signal Induction;sphingosine 1-phosphate;stem cell proliferation;stem cells;Stimulus;Testing;Tissues;tool;Visualization;Work;Zebrafish

PROJECT_TITLE: Regulation of Overall Cell Numbers During Epithelial Tissue Homeostasis and Pathogenesis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Patient Safety;Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE To reduce the risk of death, re-hospitalization, and growth faltering following hospitalizations among children living in Sub-Saharan Africa, it is critical to understand mechanisms underlying this risk, including how azithromycin affects these outcomes. Utilizing samples and data from an ongoing placebo-controlled RCT of azithromycin for post-discharge morbidity and mortality, we will characterize enteric pathogens and antibiotic resistance utilizing highly sensitive molecular diagnostic tools to determine the role of these enteric pathways on post-discharge outcomes and azithromycin’s effect.

PI_NAMEs: PAVLINAC, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Affect;Africa South of the Sahara;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Automobile Driving;Azithromycin;azithromycin resistance;Bacteria;beta-Lactam Resistance;Campylobacter;Cessation of life;Child;Child Mortality;Childhood;Clinical;clinical efficacy;Clinical Trials;clinically relevant;cohort;Communities;Cotrimoxazole;Data;Detection;Deterioration;Development;diagnostic tool;Disease;Dose;Double-Blind Method;Enteral;enteric pathogen;Enterobacteriaceae;enterotoxigenic Escherichia coli;Environment;Escherichia coli;Exposure to;Failure;Functional disorder;Genes;Genotype;Growth;high risk;HIV;hospital readmission;Hospitalization;Hospitals;improved;Intervention;Kenya;Link;Macrolide-resistance;Macrolides;Mediating;microbial;Molecular;molecular diagnostics;Morbidity - disease rate;mortality;mortality risk;National Institute of Child Health and Human Development;Nosocomial Infections;Nutritional;Outcome;pathogen;Pathogen detection;pathogenic bacteria;Pathway interactions;Pharmaceutical Preparations;Phenotype;Population;predictive marker;Predisposition;Prevalence;prevent;Randomized;randomized placebo-controlled clinical trial;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Recovery;recurrent infection;Reporting;repository;Resistance;resistance gene;resistome;Resource-limited setting;Risk;Risk Reduction;Role;Sampling;Shigella;stool sample;Testing;United States National Institutes of Health;Vaccines;Vital Status

PROJECT_TITLE: The role of enteric pathogens and antimicrobial resistance in driving clinical and nutritional deterioration, and azithromycin's potential effect, among children discharged from hospital in Kenya

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Pediatric

ORG_CITY: WACO

ORG_DEPT: CHEMISTRY

ORG_NAME: BAYLOR UNIVERSITY

PHR: Project Narrative: Students with blindness are systematically excluded from chemistry because of the unmet challenges of making the laboratory, data, and imagery accessible. In a collaboration involving Baylor researchers, five teachers/accessibility specialists at the Texas School for the Blind and Visually Impaired (TSBVI), and three PhD chemists with early blindness, this project is: (i) developing and testing new methods of making 2D/3D curriculum more accessible, and (ii) adapting chemistry labs at Baylor to be robotically accessible to 30 TSBVI high school students for annual Special Research Experiences. An external evaluation will use a randomized controlled trial to test the hypothesis that Special Research Experiences positively affect TSBVI student interest, confidence and sense of belonging in STEM.

PI_NAMEs: SHAW, BRYAN F. (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: 3-Dimensional;3D Print;Acetates;Affect;Age;Amyloid Proteins;Atomic Force Microscopy;Banana;Birth;blind;Blindness;braille;Butterflies;Candy;Carbohydrates;chemical property;chemical synthesis;Chemicals;Chemistry;Child;Childhood;Code;Collaborations;college;Complete Blindness;Computer Interface;cost;Dangerousness;Data;design;developmental prosopagnosia;Doctor of Philosophy;Dose;Drops;early experience;Educational Curriculum;Electron Microscopy;Electrons;Evaluation;Exclusion;experience;explicit bias;Face;Faculty;Feedback;Fingers;Funding;Hand;high school;High School Student;Image;Imagery;implicit bias;Industrialization;Institution;Institutional Review Boards;instrumentation;interest;K-12 student;Knowledge;Label;Laboratories;laboratory curriculum;Learning;Letters;Liquid substance;machine vision;Manuals;Mass Spectrum Analysis;Methods;Microscopy;millimeter;Modeling;molecular assembly/self assembly;nanoscale;Oral;Oral cavity;Outcome;Parafilm;Pliability;Printing;programs;protein aggregation;protein folding;Proteins;Protocols documentation;Randomized;Randomized, Controlled Trials;Reaction;Research;Research Design;Research Personnel;Resolution;Robot;robotic device;Robotics;role model;Safety;Schools;Science;Services;Skin;Solid;Special Education;Specialist;STEM field;Stereognosis;Structure;Students;Surveys;Tactile;teacher;Technology;Testing;Texas;Textbooks;Thin Layer Chromatography;Three-Dimensional Image;three-dimensional modeling;three-dimensional visualization;Tongue;tool;touchscreen;Training;Underrepresented Populations;Universities;vanillin;Vision;Visual;Visual impairment;Visualization;Visually Impaired Students;Wing;young adult

PROJECT_TITLE: Increasing access to chemistry for high schoolers with blindness: a program to jump start Central Texas

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: NEW YORK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE  The ability of cells to perceive mechanical cues is critical for development, tissue homeostasis, and immune function, and is dysregulated in disease states including cancer and muscular dystrophies. This project aims to reveal fundamental mechanisms of how forces transmitted through the actin cytoskeleton are converted into biochemical signals which govern cell physiology and regulate gene expression. In the near-term, our studies will enable rigorously determining the specific functions of these pathways, which in the long-term will guide efforts to target them therapeutically.

PI_NAMEs: ALUSHIN, GREGORY M (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;alpha Actinin;Binding;Biochemical;Biological Process;Biophysical Process;Biophysics;Bundling;Cell Cycle Arrest;Cell Death;Cell Line;Cell Nucleus;Cell Physiology;Cell-Matrix Junction;Cells;Cellular Assay;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Coupled;Cryo-electron tomography;Cryoelectron Microscopy;Cytoplasm;Cytoskeletal Modeling;Cytoskeleton;Data;Development;Disease;Dissection;Environment;Evaluation;Event;FHL1 gene;Filament;Fluorescence Microscopy;force feedback;Functional disorder;Gene Expression;Gene Expression Regulation;Generations;Genes;Homeostasis;immune function;in vivo;Individual;inhibitor;innovation;Knock-out;Link;Lobular Neoplasia;Malignant Neoplasms;mechanical signal;Mechanics;mechanotransduction;Mediating;Membrane;Methods;Microfilaments;Molecular Structure;Motor;Muscular Dystrophies;Myosin ATPase;nanometer resolution;Nuclear;Outcome;Output;Pathway interactions;Physical condensation;polymerization;Polymers;prevent;protein crosslink;Protein Engineering;Proteins;reconstitution;reconstruction;recruit;repaired;Reporting;Resolution;Role;Rupture;Signal Transduction;Site;Stress Fibers;Structure;Technology;Testing;Therapeutic;therapeutic target;Tissues;Transcription Factor AP-1;transcriptome sequencing;transmission process;vasodilator-stimulated phosphoprotein;Visualization;Work;ZYX gene

PROJECT_TITLE: Converting cytoskeletal forces into biochemical signals

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Rare Diseases;Wound Healing and Care

ORG_CITY: HERSHEY

ORG_DEPT: DERMATOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: These studies are designed to generate new insights into the basic cellular mechanisms that regulate cell-cell interactions, and to expose new therapeutic targets for the treatment of pemphigus and other skin diseases characterized by skin fragility.

PI_NAMEs: KOWALCZYK, ANDREW P. (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Adherens Junction;Adhesions;Adhesives;Autoantibodies;Autoimmune;Binding;Biological;Biophysics;Bulla;Cadherins;Calcium Signaling;Cell Communication;Cell Line;Cell membrane;Cell Physiology;Cell surface;Cell-Cell Adhesion;Cells;Cellular biology;Complex;Data;Dermatitis;design;desmoglein III;Desmosomes;Disease;Endocytosis;Endoplasmic Reticulum;Epithelium;experimental study;Exposure to;Foundations;Functional disorder;Genetic Models;Germ Cells;Homeostasis;human disease;Hypersensitivity;Immunoglobulin G;Inherited;insight;Intercellular Junctions;Intermediate Filaments;keratinocyte;Lipids;loss of function mutation;Mechanics;Mediating;Membrane;Membrane Lipids;Membrane Microdomains;Membrane Proteins;Metabolic;migration;Modeling;molecular dynamics;Morphology;mouse genetics;mutant;Mutation;Nature;new therapeutic target;Null Lymphocytes;optical imaging;Outcome;Outcome Study;Pemphigus;Pemphigus Vulgaris;Play;Property;Proteins;Regulation;resilience;Role;segregation;severe dermatitis, multiple allergies and metabolic wasting syndrome;Signal Pathway;Signal Transduction;Skin;skin disorder;Sterols;Structure;Syndrome;Testing;therapeutic development;therapy development;Transmembrane Domain;wasting;wound healing

PROJECT_TITLE: MECHANISMS OF DESMOSOME REGULATION IN SKIN DISEASE

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_DEPT: BIOPHYSICS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative The goal of this project is to develop novel multiparametric MRI biomarkers that precisely identify regions of brain tumor within areas of contrast-enhancement and peritumoral edema, which cannot be identified using standard MRI. Powered by recent advances in machine learning, our approach has the potential to cause a fundamental shift in the treatment management of patients with brain tumors.

PI_NAMEs: SCHMAINDA, KATHLEEN MARIE (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Address;Anatomy;Area;Artificial Intelligence;bevacizumab;Biological Markers;biomarker development;Biopsy Specimen;blood-brain barrier permeabilization;Brain Neoplasms;Brain region;chemoradiation;Clinical;contrast enhanced;Contrast Media;convolutional neural network;Data;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Edema;Enhancing Lesion;Excision;Glioblastoma;Glioma;Goals;Image;imaging biomarker;Imaging Techniques;improved outcome;indexing;Individual;Infiltration;interest;Lesion;Machine Learning;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measurement;Measures;Methods;MGMT gene;Modeling;Molecular;molecular marker;Monitor;neuro-oncology;Newly Diagnosed;novel;novel marker;outcome prediction;Patients;Perfusion;Physiological;Prediction of Response to Therapy;predictive modeling;Primary Lesion;Probability;prospective;Recurrence;response;Signal Transduction;Testing;Tissue Banks;Tissue Sample;Training;treatment effect;tumor;Tumor Burden;Tumor Markers;Work

PROJECT_TITLE: New treatment monitoring biomarkers for brain tumors using multiparametric MRI with machine learning

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: ITHACA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: Viral myocarditis is a heterogeneous disease that is difficult to study and diagnose, particularly in infants and neonates. This proposal integrates innovative single-cell and spatial analysis assays together with more traditional pathogenesis studies to identify the viral and host factors that determine the outcome of viral myocarditis in a model of neonatal myocarditis. Successful implementation of these studies will lead to entirely new approaches and molecular tools to study viral myocarditis and can lead to novel diagnostic principles or to novel treatments for acute viral myocarditis.

PI_NAMEs: DE VLAMINCK, IWIJN ;PARKER, JOHN S (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acute;Address;Area;Arrhythmia;Atlases;Bioinformatics;Biological Assay;Biological Markers;Biopsy;Blood;blood-based biomarker;Bystander Effect;Cardiac;Cardiac Myocytes;Cell Communication;Cell Death;cell injury;cell type;Cells;Child;Complex;cross-species transmission;Cytotoxic T-Lymphocytes;Data;data integration;Diagnosis;diagnosis standard;Diagnostic;diagnostic biomarker;Diagnostic Sensitivity;diagnostic strategy;Dilated Cardiomyopathy;Disease;Disease Outcome;Endothelial Cells;Endothelium;Environment;experimental study;Genetic Transcription;Heart;heart damage;Heterogeneity;Host Defense;Immune;improved;In Situ;Infant;Infection;Infiltration;Inflammatory;inhibitor;Injury;Innate Immune Response;innovation;insight;Integration Host Factors;Interferons;Knockout Mice;Knowledge;liquid biopsy;Mammalian Orthoreovirus;Maps;Measurement;Measures;Mediating;Medical;Methodology;minimally invasive;Modeling;Molecular;Monitor;mouse model;Mus;mutant;Myocarditis;Nature;Neonatal;neonatal mice;neonate;noninvasive diagnosis;novel;novel diagnostics;novel strategies;Onset of illness;Outcome;Pathogenesis;Pathologic Processes;Plasma;Play;Procedures;Process;recruit;Reovirus;Reovirus Infections;Resolution;response;RNA;Role;Sampling;Severity of illness;sex as a biological variable;single-cell RNA sequencing;spatiotemporal;success;Sudden Death;Tail;Techniques;Technology;Testing;therapeutic target;Time;Tissues;tool;transcriptome sequencing;transcriptomics;Viral;viral myocarditis;Viral Pathogenesis;viral RNA;virology;Virus;Virus Diseases;Work

PROJECT_TITLE: A spatially resolved molecular atlas of acute viral myocarditis at single-cell resolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-S(90)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE  CAR-T immunotherapy is an emerging therapeutic approach for treatment of malignancies which are refractory to conventional cytotoxic therapies such as B cell leukemia and lymphoma, but treatment failures are also common and post-CAR-T therapy relapses have been found to be common and limited the long term success of the therapy. Modulation of metabolism of CAR-T cells is emerging as an alternative strategy to overcome some of the challenges and in this application we propose MCJ, an endogenous brake for the mitochondrial metabolism, to be our target. We propose to investigate 1) the role of MCJ in human CD8 T cell metabolism and function, and 2) whether disrupting MCJ expression in CAR-T cells enhances the efficacy of this anti-cancer immunotherapy using mouse models and human cells.

PI_NAMEs: RINCON, MERCEDES  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Acute Lymphocytic Leukemia;Affect;ATP Synthesis Pathway;B-Cell Leukemia;cancer cell;cancer immunotherapy;Cancer Model;CAR T cell therapy;CD19 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cell Survival;Cells;Cellular biology;Cellular Metabolic Process;chimeric antigen receptor T cells;Chronic;clinical translation;Clinical Trials;clinically relevant;Complex;conventional therapy;cytokine;Cytoplasmic Granules;Cytosol;cytotoxic;Cytotoxic Chemotherapy;cytotoxicity;Data;effector T cell;efficacy evaluation;Engineering;Environment;Exocytosis;Failure;fatty acid oxidation;FDA approved;Generations;Glucose;Glycolysis;Goals;healthy volunteer;Human;Immune;immune function;Immune response;Immunology;Immunotherapy;improved;In complete remission;In Vitro;in vivo;influenzavirus;Inner mitochondrial membrane;Integral Membrane Protein;interest;Interleukin-2;Knockout Mice;leukemia/lymphoma;Maintenance;Malignant Neoplasms;Melanoma;Membrane Potentials;Memory;Metabolic;Metabolic Pathway;Metabolism;Methylation;Mitochondria;mitochondrial membrane;mitochondrial metabolism;mouse model;Multiple Myeloma;Mus;NADH dehydrogenase (ubiquinone);neoplastic cell;Non-Hodgkin's Lymphoma;Nonesterified Fatty Acids;Nucleotide Biosynthesis;optimal treatments;Outcome;Oxidative Phosphorylation;Pathway interactions;Patients;Production;Protein Deficiency;protein expression;Proteins;Refractory;Regimen;Relapse;relapse prevention;Respiration;Role;Source;success;T-Cell Proliferation;T-Lymphocyte;Testing;Therapeutic;Treatment Failure;tumor;Xenograft Model

PROJECT_TITLE: Enhancing mitochondrial metabolism to improve anti-tumor CD8 immune response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-L(02)M]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: SANTA BARBARA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: The goal of this project is to develop a genetically encoded calcium integrator for noninvasive whole-brain mapping of neural activity in animal models, using magnetic resonance imaging (MRI). These tools will be derived from water channels known as aquaporins, optimizing using techniques drawn from mammalian synthetic biology and molecular engineering, characterized in model cell lines and neurons, and finally demonstrated in mouse models involving chemogenetic and optogenetic neuromodulation of the neural reward circuitry. By enabling noninvasive access to neural activity at a whole-brain scale and in a repeatable fashion, the proposed work will establish a transformative capability for basic neuroscience research.

PI_NAMEs: KIPPIN, TOD EDWARD;MUKHERJEE, ARNAB  (contact);SHIH, YEN-YU IAN

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Address;Animal Model;Animals;awake;Behavior;Benchmarking;blood oxygen level dependent;blood-brain barrier crossing;Brain;Brain Mapping;brain volume;Calcium;Calcium Signaling;Cell Line;Cell membrane;Cell model;cell type;Coupling;Decision Making;Development;Diffusion Magnetic Resonance Imaging;Engineering;experience;Fiber;Fluorescence;fluorescence imaging;FOS gene;Functional Magnetic Resonance Imaging;Gene Cluster;Generations;Genes;Genetic;genetic approach;Goals;hemodynamics;Image;Immunohistochemistry;in vivo;learned behavior;lens;Link;Location;Magnetic Resonance Imaging;Maps;Memory;metallicity;Metals;Methods;Molecular;Monitor;motivated behavior;mouse model;multiphoton microscopy;Mus;neural;neural correlate;neural network;neuroimaging;Neurons;neuroregulation;Neurosciences;Neurosciences Research;Nucleus Accumbens;Operative Surgical Procedures;Optics;optogenetics;Organism;Osmosis;Outcome;Output;Pattern;Performance;pharmacologic;Photometry;Physiologic pulse;Reporter;Reporter Genes;Resolution;response;reward circuitry;Rewards;Safety;sensor;Sensorimotor functions;Sensory;Serotyping;Signal Transduction;Specificity;Stimulus;synthetic biology;System;Techniques;Technology;Testing;Tissues;tool;Toxic effect;Transgenic Organisms;Translating;uptake;Ventral Tegmental Area;Vertebrates;Viral;Visualization;Water;water channel;Work

PROJECT_TITLE: Metal-free, genetically encoded reporters for calcium recording with MRI


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: COLUMBIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Narrative One of the most common causes of death and disability in this country is from a heart attack: damage to the heart muscle. Following a heart attack, it is now clear that enzymes are made that continue to chew away at the heart muscle and eventually cause the heart to change shape and fail. This study will identify how to control a critical enzyme which causes the heart to fail following a heart attack and thereby develop new tests and treatments for patients after a heart attack.

PI_NAMEs: SPINALE, FRANCIS G (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Ablation;Adverse effects;Animal Model;Animals;Cardiovascular Diseases;Cause of Death;cell type;Cells;conditional knockout;Coronary Arteriosclerosis;Country;Development;disability;Disease;Disease Progression;Encapsulated;Enzymes;Etiology;Extracellular Matrix;Extracellular Matrix Degradation;Family;Family suidae;fibroblast-activating factor;Fibroblasts;Formulation;Gel;Gene Deletion;genetic signature;Health Expenditures;Heart;Heart failure;Hyaluronic Acid;Hydrogels;improved;inhibitor;Injectable;Interruption;Knockout Mice;Laboratories;Left;Left Ventricular Remodeling;Left ventricular structure;Malignant Neoplasms;Membrane;minimally invasive;Modeling;Molecular;Mus;Myocardial;Myocardial Infarction;Myocardium;Neoplasm Metastasis;Neoplasms;Normal tissue morphology;novel;novel therapeutics;Outcome;particle;Pathologic;Patients;Peptide Hydrolases;Performance;Phenotype;Play;Population;porcine model;prevent;Prevention;Process;Proliferating;Protease Inhibitor;protein activation;Recovery;repaired;Role;Secondary to;Shapes;small molecule;small molecule therapeutics;Specificity;Structure;Support System;Testing;Therapeutic;tool;Transgenic Organisms;translational study;Ventricular

PROJECT_TITLE: Fibroblast targeting for myocardial repair

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project narrative: Cardiac arrest is a major contributor to mortality and morbidity in the USA; current methods for monitoring the heart are antiquated and provide limited information. The technologies that we propose to develop will directly assess several new aspects of the heart such as the control by the autonomic nervous system in real-time. This will provide precise information on neural control of the ischemic heart and support novel treatments for ischemic disease by modulating autonomic nerves that project to the heart.

PI_NAMEs: SHIVKUMAR, KALYANAM  (contact);SMITH, COREY B;VRABEC, TINA LOUISE

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: analytical tool;Anti-Arrhythmia Agents;Antibodies;Area;Arrhythmia;autonomic nerve;Autonomic nervous system;Axon;bioelectricity;bioelectronics;Blood Vessels;Cardiac;Cardiac Surgery procedures;cardioprotection;Cardiovascular Diseases;Cardiovascular system;Cartoons;Catecholamines;comorbidity;Coupled;Critical Care;Data;design;Detection;Diagnostic;Disease;Electrodes;Electrophysiology (science);Elements;Epicardium;Feedback;Film;Frequencies;Goals;Heart;Heart Arrest;Heart Atrium;Heart failure;heart function;Heart Valve Diseases;hemodynamics;Heterogeneity;high risk;hypertensive heart disease;in vivo;Incidence;Individual;interest;interstitial;Intervention;Ischemia;Location;Maps;Measurement;Measures;Methods;Monitor;Morbidity - disease rate;mortality;mortality risk;multiple input multiple output;Myocardial Ischemia;Myocardium;neurochemistry;neuropeptide Y;Neuropeptides;neuroregulation;neurotransmitter release;Neurotransmitters;Norepinephrine;novel;Output;Pathology;Patients;Peptides;Performance;Periodicity;Postoperative Period;Procedures;receptor;Reflex action;Resolution;response;Scanning;sensor;Signal Transduction;Source;Stress;stressor;structural heart disease;sudden cardiac death;Survival Rate;System;Technology;temporal measurement;Therapeutic Intervention;Thinness;Time;translational potential;United States;Vagus nerve structure;Vasoactive Intestinal Peptide;Ventricular Arrhythmia

PROJECT_TITLE: Bioelectric monitoring and neuromodulation of the heart

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: This proposed project is relevant to public health because we will elucidate the mechanisms whereby bacterial antigens are trafficked to exosomes and identify the underlying protective mechanisms of exosomes derived from antigen presenting cells. This proposal is relevant to the NIAID’s mission to support fundamental and mechanistic research investigating regulatory aspects of immune signaling.

PI_NAMEs: FERRARO, MARIOLA JADWIGA (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: acid fast bacteria;adaptive immune response;adaptive immunity;Address;Advanced Development;Affect;Animals;Anti-Bacterial Agents;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;Autophagocytosis;Bacteria;Bacterial Antigens;Bacterial Infections;Bone Marrow;CD4 Positive T Lymphocytes;Cell Communication;Cell Physiology;Cells;Cellular Immunity;Cessation of life;Communication;contaminated water;cytokine;Data;Dendritic Cells;design;Development;Endosomes;exosome;extracellular vesicles;Feces;Food Contamination;Future;Gastroenteritis;Goals;Host Defense;Human;Humoral Immunities;Immune;Immune response;Immune signaling;Immune system;Immunity;in vivo;Infection;Infiltration;innovation;intercellular communication;Intranasal Administration;ITGAM gene;Knowledge;Lead;Licensing;Life;lymph nodes;Macrophage;Mediating;migration;Mission;Modeling;mouse model;Mucous Membrane;Multi-Drug Resistance;Mus;Mycobacterium tuberculosis;nanoscale;National Institute of Allergy and Infectious Disease;Natural Immunity;novel;Outcome;pathogen;Pathogenicity;Pathway interactions;Phenotype;Preventive measure;Process;Production;Proteins;Public Health;Publishing;recruit;Research;response;RNA;Role;Salmonella;Salmonella enterica;Salmonella infections;Salmonella typhimurium;Septicemia;Subunit Vaccines;T-Cell Activation;T-Lymphocyte;Th1 Cells;Therapeutic;trafficking;transmission process;Vaccine Design;Vaccines;Vesicle;Water consumption;Work

PROJECT_TITLE: The Function of Host-derived Extracellular Vesicles in Trafficking of Bacterial Antigens to Stimulate the Antibacterial Immune Response

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Gene Therapy;Genetics;Kidney Disease;Lupus;Nanotechnology

ORG_CITY: TAMPA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: PROJECT NARRATIVE The goal of this proposal is to develop a nanoparticle delivery system that enables targeted drug delivery with stable and sustained release of prednisolone at the glomeruli as a novel therapeutic approach for lupus nephritis.

PI_NAMEs: LIU, RUISHENG  (contact);MOHAPATRA, SHYAM S

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: American;Autoimmune Diseases;Binding;Biodistribution;Biological;biomaterial compatibility;Blood;Cells;Chitosan;Collagen Type IV;controlled release;Coupled;Coupling;crosslink;Data;Dendritic Cells;Deposition;design;Development;Disease;Dose;Drug Delivery Systems;Drug Kinetics;Drug Targeting;Encapsulated;End stage renal failure;Endothelium;Evaluation;Exhibits;Extravasation;Fenestrated Capillary;Flow Cytometry;Fluorescent Dyes;Gene Delivery;glomerular basement membrane;Glomerular Filtration Rate;Goals;Histology;Histopathology;Hour;Immune;Immune response;Immune Tolerance;Immunoglobulin G;improved;In Vitro;in vivo;Incidence;Injections;innovation;Kidney;Kidney Glomerulus;Label;Laboratories;Liposomes;Liquid substance;Liver;local drug delivery;Lupus;Lupus Nephritis;lupus prone mice;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;nanoparticle;nanoparticle delivery;Nephrons;new therapeutic target;novel;novel therapeutic intervention;Particle Size;Pathogenesis;Patients;Peptides;Pharmaceutical Preparations;prednisolone;Proteinuria;Regulatory T-Lymphocyte;Renal function;Role;Safety;side effect;Signal Transduction;single-cell RNA sequencing;Site;Spleen;surface coating;Symptoms;System;Systemic Lupus Erythematosus;targeted treatment;Techniques;Therapeutic;Therapeutic immunosuppression;therapeutic nanoparticles;therapeutic target;tool;transcriptome sequencing;tripolyphosphate;Validation;zeta potential

PROJECT_TITLE: Treatment of lupus nephritis with nanoparticles that selectively target kidney glomeruli

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(05)]


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Already a global epidemic, the prevalence of type 2 diabetes is expected to quickly rise in the coming decades, posing a serious threat to the global health. The goal of this project is to investigate novel molecular and physiological mechanisms in regulating beta cell function and stress responses at chromatin level, and to test a new strategy to prevent beta cell failure and ameliorate diabetes progression. Results from this study may pave the way towards next generation clinical solution for type 2 diabetes.

PI_NAMEs: WEI, ZONG  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Anti-diabetic Drugs;Anti-Inflammatory Agents;Apoptotic;B-Lymphocytes;Beta Cell;biological adaptation to stress;Biological Assay;Cell Line;Cell Physiology;Cells;Cellular Stress;Chromatin;Clinical;Collaborations;Deacetylase;Deacetylation;Development;Diabetes Mellitus;diabetes mellitus therapy;diabetes pathogenesis;Diabetic mouse;driving force;Elements;Enhancers;Epidemic;Epigenetic Process;epigenetic profiling;epigenetic regulation;epigenome;Failure;Family member;Functional disorder;gene induction/repression;Genes;Genetic;genetic corepressor;Genetic Transcription;genome-wide;global health;Glucose;glucose metabolism;Goals;High Fat Diet;Histone Deacetylase;histone modification;Histones;Human;Hyperactivity;Impairment;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;Inflammatory Response;insight;Insulin;insulin secretion;islet;Knock-out;Knockout Mice;loss of function;Mediating;Metabolic stress;Molecular;mouse model;Mus;mutant;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Nucleic Acid Regulatory Sequences;Overnutrition;Pathogenesis;Pathway interactions;pharmacologic;Phenocopy;Physiological;Predisposition;Prevalence;prevent;promoter;Receptor Signaling;recruit;Regulatory Element;Repression;Role;Signal Transduction;Sirtuins;Specificity;Streptozocin;Stress;Structure of beta Cell of islet;synergism;Testing;therapeutic evaluation;transcription factor;transcriptome;transcriptome sequencing;Vitamin D;Vitamin D3 Receptor

PROJECT_TITLE: Role of SIRT7 in the Pancreatic Beta Cells

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases;Spina Bifida

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project narrative Neural tube defects (NTDs) are debilitating and deadly congenital mallformations resulting from a failure of the neural tube – the precursor of the brain and spinal cord – to close during embryonic development. Neural tube closure is driven by active rearrangements of multiple embryonic cell types, but the ‘instructions’ for these cell movements are poorly defined. By identifying genes that control cell movements within experimentally accessible zebrafish embryos, this proposal will advance our fundamental understanding of neural tube development and help to identify new genetic risk factors for NTDs.

PI_NAMEs: WILLIAMS, MARGOT L.K. (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Address;Age;American;Animals;Automobile Driving;Brain;Cause of Death;cell behavior;cell motility;cell type;Cells;Child;Congenital Abnormality;Coupled;Defect;Development;Developmental Process;Diagnosis;Embryo;embryo cell;embryo tissue;Embryonic Development;Ephrins;Exhibits;experimental study;Extracellular Matrix;Failure;Family;Future;gastrulation;Gene Expression;Gene Expression Profile;Genes;genetic manipulation;genetic risk factor;Germ Layers;Head;Heart;improved;in vivo;Individual;innovation;Instruction;Intuition;Ligands;Link;Mesoderm;Methods;Modeling;Molecular;Morphogenesis;morphogens;Movement;neural;Neural Fold;Neural tube;Neural Tube Closure;Neural Tube Defects;Neural Tube Development;Neuroectoderm;Nodal;notochord;novel;optogenetics;Organ;Pattern;pharmacologic;Prevention strategy;Procedures;Process;programs;prospective;receptor;Reporting;response;Rod;Role;Shapes;Signal Transduction;Signaling Molecule;Specific qualifier value;Spinal Cord;Tail;Testing;Tissue-Specific Gene Expression;Tissues;transcriptomic profiling;treatment strategy;Tube;Variant;vertebrate embryos;Zebrafish

PROJECT_TITLE: Molecular drivers of tissue-specific morphogenetic programs

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: 8. PROJECT NARRATIVE The increasing development of scores (sociogenomic PGS) that predict polygenic contributions to complex behaviors and traits, like reproductive behavior and income, has the promise to improve genetic and social science research, but, if not implemented carefully, threatens to exacerbate social inequities and disparities. Through extensive review of current research on developing sociogenomic PGS, exploration of diverse viewpoints on the potential harms and benefits of sociogenomic PGS, and assessment of the legal protections and barriers for implementation, this project seeks to better understand the ethical and social impacts of this new technology. Our findings from stakeholder perspectives and development of legal case studies will provide guidance for how to move forward with sociogenomic PGS research in ways that promote public health and social justice.

PI_NAMEs: CADIGAN, ROSEMARY JEAN (contact);PRINCE, ANYA E.R.

PROGRAM_OFFICER_NAME: KAUFMAN, DAVE J

PROJECT_TERMS: Address;Admission activity;Attitude;Awareness;Behavior;Behavioral;behavioral outcome;Benefits and Risks;biobank;Biological;Case Study;Complex;Consent;Consumption;Data;Databases;Development;Diabetes Mellitus;Discrimination;Disease;Disparity;Early Diagnosis;Education;Empirical Research;Environment;Environmental Risk Factor;ethical, legal, and social implication;Ethics;Eugenics;Genes;Genetic;genetic predictors;genetic technology;genetic testing;genetic variant;Genomics;Goals;Health;Heart Diseases;high risk;Huntington Disease;implementation barriers;improved;Income;Individual;Inequity;Insurance Carriers;Interview;Laws;Legal;legal cases;Life;Maps;Measures;Medical;Methodology;Modeling;new technology;news;optimism;Outcome;Paper;Participant;Perception;personalized medicine;Policies;Policy Analysis;Policy Maker;polygenic risk score;Polygenic Traits;Population;Predictive Value;Process;Public Health;Publications;Published Comment;Regulation;Reproductive Behavior;Research;Research Design;Research Personnel;research study;Resources;Risk;Risk Behaviors;risk prediction;Role;Scanning;Scientist;Sexuality;social;social disparities;social genomics;Social Impacts;social interventions;Social Justice;Social outcome;Social Policies;social science research;Social Sciences;Source;stakeholder perspectives;Students;Surveys;symposium;Technology;Testing;trait;trend;Universities

PROJECT_TITLE: Beyond the Medical: The ELSI of Polygenic Scores for Social Traits


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Contraception/Reproduction;HIV/AIDS;Infectious Diseases;Maternal Health;Microbiome;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: Durban

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: CENTRE/AIDS PROGRAMME/RES/SOUTH AFRICA

PHR: Narrative Women are at extreme risk for HIV during pregnancy and postpartum, therefore antiretroviral pre-exposure prophylaxis (PrEP) is increasingly being used. Here, we propose to use two existing cohorts of HIV-uninfected pregnant women and their infants from Umlazi, KwaZulu-Natal to address our hypothesis that vaginal microbiota and inflammation are important mediators of HIV risk, but also of adverse birth outcomes. The project will also examine the effects of PrEP use during pregnancy and breastfeeding on infant health.

PI_NAMEs: JASPAN, HEATHER BERYL;NGCAPU, SINAYE  (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;adipokines;adverse birth outcomes;African Women;Age Months;antenatal;Anti-Retroviral Agents;Bacteria;Bacterial Vaginosis;Benefits and Risks;Biological;Biological Markers;Breast Feeding;cervicovaginal;chemokine;Child;Child Health;Clinical Investigator;Clinical Trials;cohort;Collaborations;Communicable Diseases;Consent;cytokine;Data;Development;Disadvantaged;Environment;experience;Exposure to;Female genitalia;female reproductive tract;fetal;Fetal Development;Genitalia;glucose metabolism;Growth;high risk;High Risk Woman;HIV;HIV Infections;HIV risk;Homeostasis;Immunity;Immunologics;Immunology;Impairment;Incidence;Infant;Infant Health;Infection;Inflammation;Inflammatory;inflammatory marker;inflammatory milieu;Inflammatory Response;innovation;Insulin Resistance;intervention refinement;Lactation;Lactobacillus;Late pregnancy;Liquid substance;Measures;Mediator;Metabolic;Metabolic Diseases;Metabolism;Metagenomics;Microbe;microbial;microbial community;microbiome;Mitochondria;Mucous Membrane;multiplex assay;natural Blastocyst Implantation;Natural Immunity;neonatal morbidity;neonate;Neurologic;Outcome;Parents;Pharmaceutical Preparations;Plasma;Postpartum Period;pre-exposure prophylaxis;Predisposition;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Premature Infant;Premature Labor;Preparation;Prevalence;prevent;Province;recruit;Research;Research Personnel;Risk;Risk Factors;risk mitigation;risk prediction;safety and feasibility;Sampling;Scientist;Second Pregnancy Trimester;South African;stillbirth;Swab;Technology;Time;Toxic effect;transmission process;Underrepresented Populations;Universities;Vagina;vaginal fluid;vaginal microbiota;Visit;Woman

PROJECT_TITLE: Combination biomarkers for preventing HIV and adverse birth outcomes in a South African pregnancy cohort: implications for infant health


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Rare Diseases;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Cerebral amyloid angiopathy (CAA) often co-exists with Alzheimer's disease (AD) and is a sexually dimorphic disease (similar to AD). We will study sex differences in the role of fibrin and it's cross talk with inflammatory pathways across the lifespan and determine if inhibition of fibrin/ fibrosis can decrease the CAA disease burden.

PI_NAMEs: MANWANI, BHARTI  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta deposition;advanced disease;Age;Age Months;aged;Aging;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Amyloid deposition;amyloid pathology;arm;behavioral outcome;Biological;Blood;Blood Vessels;Brain;Brain hemorrhage;brain parenchyma;Brain Pathology;brain tissue;burden of illness;Cerebral Amyloid Angiopathy;Cerebral cortex;Cerebral hemisphere hemorrhage;cerebral microbleeds;Cerebrovascular system;Clinical;Cognition;cognitive function;Complex;conditioned fear;Data;Dementia;Deposition;design;Development;Diagnosis;disability burden;Disease;Disease Progression;Drug usage;Elderly;Elderly woman;Enzyme-Linked Immunosorbent Assay;expectation;Female;Fibrin;Fibrinogen;Fibrosis;Flow Cytometry;Genetic;glial activation;Hemorrhage;Histology;Human;immune cell infiltrate;Immunohistochemistry;Impaired cognition;Inflammation;Inflammatory;inhibitor;Integrins;Interleukin-1 beta;Iowa;ITGAM gene;ITGB2 gene;Lead;life span;lifetime risk;Ligands;Link;Magnetic Resonance Imaging;male;Measurement;Mediating;Memory;men;Microglia;middle age;Modeling;monocyte;mortality;mouse model;Multiple Sclerosis;Mus;Nerve Degeneration;Neurons;neuroprotection;novel;Oral Administration;Outcome;Pathologic;Pathology;Pathway interactions;Patients;peripheral blood;Pharmaceutical Preparations;pharmacologic;Phenotype;Pirfenidone;Plasma;Plasmin;Plasminogen Activator Inhibitor 1;Play;Prevalence;Probability;Pulmonary Fibrosis;Radial;receptor;response;Role;Severity of illness;sex;Sex Differences;sexual dimorphism;single-cell RNA sequencing;Site;Specificity;System;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Tissue Sample;TNF gene;Transforming Growth Factor beta;Tunica Adventitia;Vascular Dementia;verbal;water maze;Widespread Disease;Woman;Work;β-amyloid burden

PROJECT_TITLE: Mechanisms underlying Sex differences in Cerebral Amyloid Angiopathy: The Fibrin-Microglia Crosstalk

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Biotechnology;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The Primary Immune Deficiency Treatment Consortium (PIDTC) has built multicenter collaborations at 47 centers in the US and Canada to learn best treatment strategies and improve outcomes for primary immune deficiencies (PIDs). The PIDTC Annual Scientific Workshops, begun in 2011 and continuously funded by R13 awards, bring together a diverse group of investigators, physicians, patient advocates and trainees to focus on critical topics in severe combined immunodeficiency (SCID), Wiskott-Aldrich syndrome (WAS), chronic granulomatous disease (CGD) and primary immune regulatory disorders (PIRD). The 3 upcoming PIDTC Scientific Workshops and Education Days are planned to be in Cincinnati, Ohio, in April 2023, followed by Atlanta, GA, and Washington, DC, with the 2023 meeting titled “New Treatments for Primary Immune Disorders.”

PI_NAMEs: PUCK, JENNIFER M. (contact)

PROGRAM_OFFICER_NAME: BARTELS, ADELINA EWURA-ABENA

PROJECT_TERMS: Advocate;Affect;Autoimmunity;Award;Awareness;Biological Markers;Biological Products;Canada;Cell Therapy;Cells;Chronic Granulomatous Disease;Clinical;clinical development;Clinical Research;Clinical Trials;Collaborations;Collection;Communication;conditioning;congenital immunodeficiency;COVID-19 pandemic;Data;Data Analyses;Data Collection;Data Set;Defect;Disease;Education;Educational workshop;Engraftment;enzyme therapy;evidence based guidelines;experience;Fostering;Funding;Future;gene therapy;Genes;Goals;graft vs host disease;Grant;Health;Hematopoietic Stem Cell Transplantation;Immune;immune function;immune reconstitution;Immune system;Immune System Diseases;immunoregulation;improved;improved outcome;Individual;Infant;Infection;International;Intervention;Late Effects;Learning;Life;Malignant - descriptor;Malignant Neoplasms;meetings;member;National Institute of Allergy and Infectious Disease;Natural History;Neonatal Screening;next generation;novel strategies;Ohio;optimal treatments;Outcome;Outcome Study;Participant;participant enrollment;patient advocacy group;Patients;Persons;Physicians;Predisposition;Preparation;primary immune regulatory disorders;prospective;Prospective Studies;Protocols documentation;public education;Rare Diseases;recruit;Regimen;Replacement Therapy;Request for Applications;Research;Research Personnel;Retrospective Studies;Risk;Risk Factors;Scientist;Severe Combined Immunodeficiency;Site;Source;Supportive care;synergism;Toxic effect;Training;transplantation therapy;Treatment Protocols;treatment strategy;Underrepresented Minority;United States National Institutes of Health;Update;virtual;Washington;Wiskott-Aldrich Syndrome;Woman

PROJECT_TITLE: Annual Primary Immune Deficiency Treatment Consortium (PIDTC) Workshop and Education Day


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Comparative Effectiveness Research;Infectious Diseases;Prevention;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The proposed research is relevant to public health because peri-prosthetic infection (PJI) is a significant healthcare burden, which not only impacts very detrimentally the patients’ morbidity and mortality but also exponentially increases the cost of treatment for total joint replacements. Thus, the proposed research to develop a platform bearing surface technology and implementation strategies to treat PJI is relevant to the part of NIH’s mission that pertains to the application of our fundamental knowledge of living systems to enhance health, lengthen life, and reduce illness and disability.

PI_NAMEs: ORAL, EBRU  (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: alternative treatment;Amputation;Analgesics;Anti-Bacterial Agents;anti-microbial drug;Antibiotics;antimicrobial;Antioxidants;Arthrodesis;Attention;Bacterial Infections;Biomedical Engineering;Biometry;Bone Cements;Bupivacaine;Caring;chemotherapy;Clinical;clinical development;clinically relevant;Communicable Diseases;Complication;controlled release;cost;crosslink;Data;design;Devices;disability;Economic Burden;efficacy testing;Engineering;Excision;Failure;Formulation;Gentamicins;Goals;Growth;Health;healthcare burden;Immobilization;immunological status;Implant;implant material;implantation;implementation strategy;improved;improved outcome;In Vitro;in vivo;Infection;Inflammatory;innovation;joint infection;Joints;Ketorolac;Knowledge;Life;Link;mechanical properties;Mechanics;Medical Device;Methods;Microbial Biofilms;microorganism;Mission;Modality;Modeling;Morbidity - disease rate;Morphology;mortality;Nature;Non-Steroidal Anti-Inflammatory Agents;novel;Operating Rooms;Operative Surgical Procedures;Oral;Organ Transplantation;Organism;Orthopedic Surgery;Orthopedics;Outcome;Patients;Periprosthetic joint infection;Pharmaceutical Preparations;pharmacodynamic model;Polymers;pre-clinical;Pre-Clinical Model;prevent;Prevention;Probability;Procedures;Property;Public Health;Quality of life;Rattus;Recurrence;recurrent infection;Replacement Arthroplasty;Research;Resistance;Risk;Risk Assessment;risk stratification;Safety;sample fixation;standard care;Staphylococcal Infections;Staphylococcus aureus;Surface;synergism;System;Technology;technology platform;Testing;Therapeutic;Time;Treatment Cost;treatment duration;Treatment Failure;treatment risk;ultra-high molecular weight polyethylene;United States National Institutes of Health;Vancomycin;Weight-Bearing state;Work

PROJECT_TITLE: Drug-eluting joint implants with synergistic antimicrobial release and risk stratified models of preclinical efficacy testing

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Relevance/Project Narrative Production of collagen matrix during postnatal heart development is critical for proper growth and maturation of this organ, and related pathways are responsible for the accumulation of fibrotic material in the heart of post-MI patients. Cardiac fibrosis contributes to progressive heart disease, and new therapies directed at limiting the fibrotic response are desperately needed, especially end stage heart failure. This dual-PI application will investigate the crosstalk between cardiac fibroblasts and muscle cells mediated by extracellular matrix that contribute to development and disease progression with the goal of defining new targets for future therapeutic strategy development.

PI_NAMEs: MOLKENTIN, JEFFERY D;YUTZEY, KATHERINE E (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Address;Adult;Area;autocrine;Award;Back;Birth;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiomyopathies;cell type;Cells;Characteristics;Cicatrix;Collagen;Collagen Type I;Communication;Congenital Abnormality;coronary fibrosis;Data;Deposition;Development;Disease;Disease Progression;Embryo;emerging adult;Epidermal Growth Factor;Extracellular Matrix;Family member;Feedback;fetal;Fibroblasts;Fibronectins;Fibrosis;Funding;Future;Gene Expression Profiling;Gene Targeting;Genes;Geometry;Goals;Growth;growth differentiation factor 10;Growth Factor;Heart;Heart Diseases;Heart failure;heart function;Homeostasis;Human;Hypertrophy;Impairment;Injury;Investigation;Ligands;Mediating;Medical;metaplastic cell transformation;Modeling;Mus;Muscle Cells;Myocardial Infarction;Myofibroblast;Nature;Neonatal;neonatal period;novel;novel therapeutics;Organ;paracrine;Pathway interactions;Patients;pleiotrophin;postnatal;postnatal development;Process;Production;programs;Proliferating;Properdin;Pump;receptor;response;response to injury;Signal Transduction;Stimulus;Therapeutic;therapeutic target;Time;Tissues;Transforming Growth Factor beta;Transforming Growth Factors;transmission process;Ventricular;Ventricular Remodeling

PROJECT_TITLE: Cardiac Fibroblasts in Postnatal Development and Adult Injury Response

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative Sickle cell disease (SCD) is a devastating, painful hereditary blood disorder with significant global morbidity and early mortality. Hematopoietic stem cell (HSC) transplantation remains the only curative therapeutic option, however little is known about the impact of SCD pathophysiology on HSCs. This project will identify mechanisms by which SCD impairs HSC function, thereby highlighting targetable pathways to improve the safety, efficiency, and accessibility of autologous HSC transplantation following gene therapy for SCD.

PI_NAMEs: BARVE, ADITYA SHIRISH (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Abnormal Hemoglobins;Age;Age Months;aged;Aging;Animal Diseases;Animals;ATAC-seq;Autologous;Autologous Transplantation;Biochemical;Biological Assay;Bone Marrow;Bone Marrow Aspiration;Cancer Biology;career development;Carrying Capacities;cell age;Cell Compartmentation;Cell Cycle;cell injury;Cell Proliferation;Cell Separation;Cells;chemotherapy;Chronic;Clinical;Clinical Trials;curative treatments;cytokine;Data Analyses;Data Set;differentiation in vitro;DNA Damage;Environment;Epigenetic Process;Erythrocytes;Erythropoiesis;exhaustion;Exposure to;fitness;Flow Cytometry;Frequencies;Functional disorder;gene therapy;Genes;Genetic Transcription;Glean;Goals;hallmarks of aging;Health;Hematologic Neoplasms;Hematological Disease;Hematology;Hematopoietic;Hematopoietic Neoplasms;hematopoietic stem cell differentiation;Hematopoietic Stem Cell Mobilization;Hematopoietic Stem Cell subsets;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobin;hemoglobin polymer;Hemolysis;Human;immune activation;immunodeficiency;Impairment;improved;In Vitro;in vivo;Inflammation;Inherited;insight;Institution;Investigation;Knowledge;Laboratories;Lead;Learning;Mediating;Meditation;Mentorship;Molecular;Molecular Probes;Molecular Profiling;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;Mutation;Myelogenous;novel;Organ;Output;Oxygen;Pain;Pathway interactions;Patients;Phenotype;Pilot Projects;Ploidies;Positioning Attribute;post-transplant;Postdoctoral Fellow;premature;promoter;Regimen;Research Personnel;Resource Development;Resources;Risk;Safety;Saint Jude Children's Research Hospital;self-renewal;Sickle Cell;Sickle Cell Anemia;sickling;Source;stem cell biology;stem cell function;Stress;systemic inflammatory response;Testing;Time;Training;training opportunity;transcriptome sequencing;Transgenic Organisms;Translating;Transplantation;Work;Xenograft procedure

PROJECT_TITLE: Mechanisms and consequences of sickle cell disease-induced cycling in hematopoietic stem cells


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative HCC is one of the most common cancers with an incidence rate that has the highest increase amongst all cancers over the last decade. Our proposed studies focus on discovering the critical changes in the diabetic liver that provide a pro-invasive milieu for transformed cells. We will focus on matrix behavior that is permissive for invasion or metastasis, and these studies will result is data that will directly be translatable to human HCC and will advance the field in HCC therapeutics.

PI_NAMEs: TOROK, NATALIE J. (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Advanced Glycosylation End Products;Affect;Amino Acids;Animal Model;Architecture;Behavior;beta catenin;cancer cell;carcinogenicity;cell behavior;cell motility;cell transformation;Cells;Cirrhosis;Clinical;Collagen;crosslink;Data;Deposition;diabetic;Diet;Disease Progression;Down-Regulation;Elasticity;Embryo;Environment;Epidemic;Exhibits;Future;glycemic control;Hepatocyte;Human;Hydrogels;improved;in vitro Model;in vivo;in vivo Model;Incidence;inhibitor;Injections;Injury;Invaded;Lead;Link;Liver;liver cancer model;liver injury;Malignant Neoplasms;Mediating;migration;Modeling;Mus;mutant;Neoplasm Metastasis;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Obesity;Outcome;Pathway interactions;Patients;permissiveness;Phenotype;Prevalence;Primary carcinoma of the liver cells;Production;Proliferating;Property;Proteoglycan;Pyridoxamine;receptor;receptor for advanced glycation endproducts;Relaxation;response;Risk Factors;sex;Signal Transduction;Stress;System;Techniques;tensin;Testing;Therapeutic;three-dimensional modeling;Time;Tissues;transcriptome sequencing;translational study;tumor;Tumor Burden;viscoelasticity;Viscosity;Work

PROJECT_TITLE: Matrix in pre-cirrhotic HCC

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Dementia;Dietary Supplements;Lewy Body Dementia;Neurodegenerative;Neurosciences;Nutrition;Parkinson's Disease;Prevention

ORG_DEPT: NUTRITION

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE The proposed research is relevant to public health and NIA’s mission for the division of neuroscience as understanding vitamin D and K’s role in Alzheimer's disease and related dementias of aging offers a potentially important, novel, and low-cost intervention for populations at higher risk for dementia. A thorough analysis of this relationship will ultimately allow researchers to clarify the forms of vitamin D and vitamin K important to dementia and justify the conduct of future vitamin D and K supplementation trials.

PI_NAMEs: BOOTH, SARAH LOUISE (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: 25-hydroxyvitamin D;African American;African American population;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Anterior;Autopsy;Biological;Blood specimen;Blood Vessels;Brain;Brain region;brain tissue;Cerebellar vermis structure;Cessation of life;circulating biomarkers;Cognitive;cognitive function;cohort;Communities;Consumption;cost;Data;deep learning;Dementia;dementia risk;Deposition;Development;Dietary Factors;disorder risk;Elderly;Foundations;Future;Gait speed;Goals;gray matter;Health Care Costs;Hemorrhage;high risk;Hippocampus;Impaired cognition;Impairment;indexing;Inferior;innovation;insight;Intake;intervention cost;Investigation;Lewy Bodies;Lewy Body Dementia;Link;Magnetic Resonance Imaging;Measures;Memory;Microvascular Dysfunction;Minority;Mission;Motor;motor symptom;multidisciplinary;neocortical;Nerve Degeneration;Neurofibrillary Tangles;neuroimaging;neuropathology;Neurosciences;novel;Nutrient;older adult;older men;Older Population;older women;Outcome;Parkinson Disease;Parkinsonian Disorders;Participant;Pathogenesis;Pathology;Physical Function;Population;Population Intervention;Productivity;protective effect;Public Health;Recommendation;Research;Research Personnel;research study;Resources;Risk Factors;Role;Sampling;Solid;Structure;Supplementation;Temporal Lobe;Testing;Tissues;Vitamin D;Vitamin K;Vitamin K 1;Vitamin K 2;Vitamins;white matter;White Matter Hyperintensity

PROJECT_TITLE: Vitamin K and D and Cognitive Impairment in Older Adults


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Nutrition;Obesity

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Advanced age and obesity are important risk factors for Alzheimer's disease (AD). We have discovered a novel metabolic pathway that profoundly influences longevity and obesity in mice. We will investigate the hypothesis that inhibition of this pathway in genetically-modified mice will reduce AD neuropathology and cognitive deficit, including in mice fed a high-fat diet.

PI_NAMEs: FOX, PAUL L (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: 3xTg-AD mouse;Adipocytes;adipokines;Adipose tissue;age acceleration;age related;Aging;aging biomarker;aging process;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amino Acyl-tRNA Synthetases;Amish;Animal Model;Behavior;Biological Aging;Brain;Breeding;CCL2 gene;Cell Aging;Chronic;Chronic Disease;Clinical Trials;Coenzyme A;Cognitive;Cognitive deficits;cognitive function;Communities;Complex;Cyclin-Dependent Kinases;Data;Development;diet-induced obesity;Disease Progression;Disease susceptibility;Elderly;Exhibits;extend lifespan;Gene Modified;Genes;Genetic;Genetic Code;Genetic Diseases;Geroscience;High Fat Diet;Impaired cognition;Inflammation;Inflammatory;inhibitor;Insulin;Insulin Resistance;Intervention;Intervention Studies;Knock-in;Knock-in Mouse;Knock-out;Knowledge;Laboratories;LCN2 gene;Learning;Ligase;Longevity;Mediating;Mediator;member;Memory;Metabolic Pathway;Molecular;Molecular Target;mouse model;Mus;Mutant Strains Mice;Mutation;neuropathology;novel;novel therapeutics;null mutation;Obesity;Onset of illness;Pathogenesis;Pathway interactions;pharmacologic;Phosphorylation;Phosphorylation Site;Phosphotransferases;Plasminogen Activator;pre-clinical;Process;programs;proline-tRNA;Proteins;Role;senescence associated secretory phenotype;SERPINE1 gene;Serum;Severities;side effect;Signal Transduction;Site;Testing;Therapeutic;Thinness;Tissue Donors;Tissue Transplantation;Transfer RNA;Transplantation;Visceral;Wild Type Mouse

PROJECT_TITLE: Adipokines, Aging, and Alzheimers Disease


ADMINISTERING_IC: OD

ED_INST_TYPE: PRIMATE CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Transplantation;Vaccine Related

ORG_CITY: LAFAYETTE

ORG_NAME: UNIVERSITY OF LOUISIANA AT LAFAYETTE

ORG_STATE: LA

PHR: Cytokines and chemokines are bioactive molecules produced in responses to physiological events, directing and shaping immune responses to immunization, infection, transplantation and disease, and many such molecules are being considered for therapeutic use or as part of natural immune adjuvants to vaccination. These molecules are however species specific and utilizing human or rodent cytokines in nonhuman primates often leads to erroneous results due to the fact that NHPs will rapidly mount immune responses against the foreign proteins. Thus, the goals of this grant are to continue and to expand the services and reagents provided by this unique resource to investigators using nonhuman primates as preclinical models for human disease and immunotherapy.

PI_NAMEs: VILLINGER, FRANCOIS J (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adjuvant;Affinity;African Green Monkey;Allogenic;Animal Model;antagonist;Antibodies;Antibody Response;Aotus primate;Autoimmune Diseases;Award;behavioral study;Biological;Budgets;Callithrix jacchus jacchus;Cebidae;Cells;Cercocebus atys;Charge;chemokine;Clinical;Collaborations;Communicable Diseases;Complementary DNA;cost;cross reactivity;CSF3 gene;cytokine;Cytokine Receptors;design;Development;Disease;DNA;Dose;embryonic stem cell;Event;expression vector;FLT3 ligand;Fluorescent Probes;Funding;Generations;Genes;Genetic;Genome;Goals;Grant;Granulocyte-Macrophage Colony-Stimulating Factor;Growth Factor;HIV Infections;HIV/AIDS;Homologous Gene;Human;human disease;human model;IL16 gene;IL17 gene;IL18 gene;IL7 gene;Image;Imaging ligands;Imaging technology;Immune;immune modulating agents;Immune response;Immunization;Immunologic Adjuvants;Immunologic Markers;Immunologic Receptors;Immunologics;Immunomodulators;immunoregulation;Immunotherapy;In Vitro;in vivo;in vivo evaluation;in vivo imaging;Infection;Interferons;Interleukin-1;Interleukin-10;Interleukin-12;Interleukin-15;Interleukin-16;Interleukin-2;interleukin-21;interleukin-22;interleukin-23;Interleukin-4;Interleukin-5;Interleukin-6;Investigation;Laboratories;Letters;Ligands;Macaca;Malaria;man;member;Methods;Modeling;Monkeys;Monoclonal Antibodies;Multiple Sclerosis;Names;neutralizing antibody;neutralizing monoclonal antibodies;nonhuman primate;novel;Operative Surgical Procedures;Organ;Papio;Pathogenesis;Peptides;Physiological;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Preparation;Primates;Procedures;programmed cell death ligand 1;programmed cell death protein 1;promoter;Proteins;Protocols documentation;Reagent;reagent standardization;receptor;Recombinant Cytokines;Recombinant DNA;Recombinants;Reproductive Biology;Request for Applications;Research;Research Personnel;Resources;response;Rodent;Sampling;Schedule;Schistosomiasis;Seminal;Services;Shapes;SIV;Source;Standardization;stem cell therapy;Study models;Technology;Testing;Therapeutic;Therapeutic Uses;TNF gene;TNFRSF10B gene;tool;transplant model;Transplantation;transplantation medicine;United States National Institutes of Health;Vaccination;vaccine efficacy;vaccine immunotherapy;Viral Markers;Work

PROJECT_TITLE: Resource for Nonhuman Primate Immune Reagents


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Hearing Loss;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_DEPT: OTOLARYNGOLOGY

PHR: Noise-induced hearing loss affects nearly 40 million Americans. We have newly identified a pathway critically involved in the ear's early response to loud sound. In this grant, we aim to learn more about how this pathway is involved in hearing and deafness, so that we may develop drugs to target this pathway and prevent hearing loss.

PI_NAMEs: CHAN, DYLAN  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Affect;American;Animal Model;Apoptosis;Apoptotic;arm;Attenuated;Biochemical;Biological Models;Ca(2+)-Transporting ATPase;Calcium;Caspase;Cell Death;Cell Line;Cell model;Cell Survival;cell type;Cells;Cellular Stress;Chemicals;Clinical;clinically relevant;Cochlea;conditional knockout;Critical Pathways;Cytoplasm;Cytosol;Data;deaf;deafness;Development;Ear;Endoplasmic Reticulum;endoplasmic reticulum stress;Equilibrium;Event;Exhibits;experimental study;Family;FDA approved;Foundations;Functional disorder;Gene Expression;Genes;Genetic;genetic deafness;Genetic Models;Genetic Techniques;Genetic Transcription;Gerbils;Grant;Hair Cells;Hearing;hearing impairment;Heterozygote;Homeostasis;Hour;Human;Image;Impairment;in vivo;in vivo Model;Induction of Apoptosis;insight;Knock-out;Knockout Mice;Learning;Link;Loudness;Macromolecular Complexes;Measures;Mediating;Mediator;Messenger RNA;Modeling;multidisciplinary;Mus;Mutation;Neonatal;Noise;noise exposure;Noise-Induced Hearing Loss;normal hearing;novel;ototoxicity;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Phase;Physiological;positive allosteric modulator;Predisposition;prevent;prevent hearing loss;Process;progressive hearing loss;protein folding;Proteins;Public Health;Publishing;release of sequestered calcium ion into cytoplasm;Research Proposals;response;reuptake;Role;segregation;Series;Signal Transduction;sound;Specificity;Stimulus;Supporting Cell;targeted treatment;Testing;therapeutic development;therapeutic target;Time;Translational Research;Trauma;Up-Regulation;Variant;Wild Type Mouse

PROJECT_TITLE: The role of TMTC4, endoplasmic reticulum Ca2+ flux, and the unfolded protein response in noise-induced hearing loss

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Despite having therapeutic effects, marijuana use leads to a wide range of adverse physical and mental effects. One important way to reduce these harmful public health consequences is by imposing excise taxes on retail marijuana. We propose to evaluate how excise tax structures impact marijuana consumption and product choices among different marijuana forms and between legal and illegal products. The empirical evidence will inform how to set excise tax structures to mitigate harms for states contemplating taxation policies as they legalize, and for states and localities with legal retail sales contemplating reforms to their current tax structures.

PI_NAMEs: SHANG, CE  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Address;Adult;Age;Alcohols;authority;base;Border Crossings;Calibration;Cannabis;Cannabis retail;Cigarette;cohort;Consumption;design;District of Columbia;Effectiveness;experimental study;Flowers;Goals;Harm Reduction;Health;infancy;innovation;Intention;interest;Knowledge;Legal;Link;Marijuana;marijuana legalization;marijuana use;marijuana user;Marketing;Methods;Modeling;National Institute of Drug Abuse;Natural experiment;nonmedical use;Outcome;Participant;Persons;Policies;policy implication;Policy Maker;Population;Predisposition;preference;prevent;Price;Probability Samples;Process;prospective;Psyche structure;Public Health;reduce marijuana use;Reporting;response;Sales;Structure;Surveys;Taxation;Taxes;Tetrahydrocannabinol;Therapeutic Effect;Time;trend;Weight;young adult;Youth

PROJECT_TITLE: The impact of excise tax structures for retail marijuana on marijuana consumption

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: IOWA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative  Chlamydia trachomatis is the etiological agent of blinding trachoma and a sexually transmitted infection that can result in serious complications including pelvic inflammatory disease (PID), ectopic pregnancy, and infertility. The molecular mechanisms used by C. trachomatis to co-opt host vesicular trafficking for the acquisition of essential nutrients are poorly understood since until recently chlamydia was intractable to genetic manipulation. This proposal will define how the essential C. trachomatis Inc protein, CT229, coordinates interactions with host and bacterial factors to acquire essential nutrients required for proliferation and inclusion stability, which will ultimately identify novel targets for therapeutic intervention and greatly expand our understanding of host-pathogen interactions.

PI_NAMEs: WEBER, MARY  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Address;Animal Model;Antibiotic Therapy;Bacteria;Bacterial Infections;Bacterial Proteins;Binding;Blindness;Cell Culture Techniques;Cells;Ceramides;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Complex;Data;Defect;Development;Disease;Ectopic Pregnancy;Endosomes;Etiology;Genetic;genetic manipulation;global health;Goals;Golgi Apparatus;Growth;Impairment;Incidence;Infection;Infertility;insight;Integration Host Factors;Iron;Knowledge;Label;Lipids;Mediating;Membrane;Membrane Proteins;Metabolism;Microtubules;Molecular;new therapeutic target;novel therapeutic intervention;Nutrient;Nutritional Requirements;Organelles;Paper;pathogen;Pathogenesis;Pathway interactions;Pelvic Inflammatory Disease;Positioning Attribute;Prevalence;Process;Proliferating;Proteins;rab GTP-Binding Proteins;recruit;Recurrence;Recycling;Reporting;Role;Sexual Transmission;Sexually Transmitted Diseases;SNAP receptor;Source;Techniques;Therapeutic Intervention;Trachoma;trafficking;trans-Golgi Network;Transferrin;Vacuole;Vesicle;vesicle transport;Work

PROJECT_TITLE: Functional characterization of Chlamydia trachomatis inclusion membrane proteins and their role in subversion of host vesicular trafficking

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Obesity

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Oxidative stress is often associated with inappropriate activation of immune cells, including macrophages, leading to atherosclerosis which is the underlying cause of heart attacks, strokes, and ischemic limb loss. This project seeks to identify and characterize mechanisms that link oxidative stress in fat cells (adipocytes) to chronic macrophage activation through activation of specific cellular receptors and release of bioactive materials. The novel molecular pathway identified in this proposal could lead to new strategies for therapeutic interventions.

PI_NAMEs: CHEN, YILIANG ;SILVERSTEIN, ROY L (contact);SODHI, KOMAL

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: adipocyte biology;Adipocytes;adipokines;Adipose tissue;Amino Acids;Animal Model;Apolipoprotein E;Arterial Fatty Streak;Arteries;atherogenesis;Atherosclerosis;Attenuated;Binding;Biochemical;Biological Assay;Cause of Death;CD36 gene;cell type;Cells;Chronic;chronic inflammatory disease;Complex;cytokine;Data;Development;diagnostic biomarker;Distant;driving force;Dyslipidemias;exosome;Foam Cells;Gene Expression;Gene Expression Profiling;Genetic;Goals;Hormones;immune activation;improved;In Vitro;in vivo;Incubated;Inflammation;Inflammatory;inhibitor;Injections;Ions;Knockout Mice;Label;Lentivirus Vector;Ligands;limb ischemia;limb loss;Link;lipid metabolism;lipidome;lipidomics;Lipids;Location;Macrophage;Macrophage Activation;Mediating;Mediator;Membrane;Metabolic;Methods;MicroRNAs;Mitochondria;Modeling;Molecular;Molecular Conformation;molecular phenotype;monocyte;mouse model;Mus;Myocardial Infarction;N Domain;new therapeutic target;next generation;novel;novel diagnostics;novel therapeutic intervention;oxidant stress;Oxidative Stress;oxidized low density lipoprotein;paracrine;Pathway interactions;Peptide Initiation Factors;Peptides;Phenotype;Phosphotransferases;Play;Production;Proteins;Proteome;Publishing;Pump;Reagent;receptor;release factor;Reporter;response;Risk Factors;Role;scaffold;scavenger receptor;Signal Transduction;src-Family Kinases;Stroke;Study models;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissues;trafficking;transcriptome sequencing;Work

PROJECT_TITLE: NKA/CD36 signaling in adipocytes promotes oxidative stress and drives chronic inflammation in atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Antisense oligonucleotides are a powerful tool to study RNA function that cleave the desired target by recruiting endogenous RNase H; yet they have limited clinical utility and have off-targets. Herein, we propose to further develop the small molecule equivalent of antisense oligonucleotides, where we have engineered small molecules that selectively bind to a given RNA target to recruit an endogenous RNase, a strategy that provides a powerful and facile platform for selective destruction of any RNA. We will apply these methods to disable an oncogenic miRNA that has known roles as a driver of metastatic triple negative breast cancer and seek to improve small molecule selectivity, potency and efficacy in breast cancer cells both ex vivo and in vivo.

PI_NAMEs: DISNEY, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Animals;Antisense Oligonucleotides;Apoptosis;Base Sequence;Benchmarking;Binding;Binding Proteins;Biogenesis;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;Breast Epithelial Cells;Cancer Center;Cell Proliferation;Cells;Chimera organism;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complementary RNA;derepression;design;Development;Disease;efficacy evaluation;efficacy testing;Engineering;Evaluation;Genetic Transcription;Goals;Human;improved;In Situ;In Vitro;in vivo;in vivo evaluation;Invaded;knock-down;Laboratories;Lead;lead optimization;Malignant Breast Neoplasm;Malignant Neoplasms;MDA MB 231;Medicine;Methods;MicroRNAs;migration;Modality;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel therapeutic intervention;nuclease;Oligonucleotides;Oncogenic;Patients;Pharmaceutical Preparations;Phenotype;Production;programs;Proliferating;Property;Protac;Protein Inhibition;Proteins;Proteome;rational design;recruit;relapse prevention;Resources;response;Ribonuclease H;Ribonucleases;RNA;RNA Binding;RNA Degradation;RNA Splicing;Role;Safety;Site;small molecule;stem cell biomarkers;targeted treatment;Testing;tool;transcriptome;Triage;triple-negative invasive breast carcinoma;tumor;Tumor Suppressor Proteins;Tumor Tissue;tumorigenesis;Untranslated RNA;Validation;Xenograft Model

PROJECT_TITLE: Targeted degradation of RNAs by using small molecules

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Aging;Brain Disorders;Neurosciences

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE CHIP is a key enzyme in cellular protein quality control. On a cellular level, altered CHIP function sensitizes cells to stress, and at an organismal level, the inability to respond to stress results in degenerative pathologies and accelerated aging. Our overall goal is to determine the mechanisms and dysfunction caused by disease-causing CHIP mutations at the atomic, cellular, and whole-body level. We will use novel cell systems in combination with our preclinical models to test novel therapies to counteract the loss of CHIP function. In doing so, we will establish a new framework to better understand this aging and CHIP biology that, in turn, will allow us to develop precision medicine approaches to alleviate degeneration caused by the loss of CHIP function.

PI_NAMEs: SCHISLER, JONATHAN C. (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: 5'-AMP-activated protein kinase;Active Sites;Adult;age acceleration;age effect;age related;age-related disease;Aging;Alzheimer's Disease;Apoptosis;Atrophic;autosome;Binding Proteins;Biochemical;Biology;biophysical techniques;Body System;Cardiovascular Diseases;Cell Culture Techniques;Cell Death;Cell model;Cell Physiology;Cells;Cellular Metabolic Process;Cellular Stress;Cerebellar Ataxia;Cerebellar degeneration;Cerebellum;clinical phenotype;Code;Cognition;Complex;Defect;Degenerative Disorder;Disease;disease-causing mutation;druggable target;Energy Metabolism;engineered stem cells;Enzymes;flexibility;Functional disorder;Genetic Diseases;Goals;Health;Heart failure;Heat-Shock Response;human disease;Human Genetics;Hypogonadism;Impaired cognition;induced pluripotent stem cell;Inflammatory;Link;loss of function;Mediating;Mediator;member;Metabolic;Metabolic stress;Metabolism;Molecular;Molecular Chaperones;Molecular Conformation;Motor;mouse model;Movement;multicatalytic endopeptidase complex;Mus;Mutation;Nerve Degeneration;Neurologic;Neurons;novel;novel therapeutics;pathological aging;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphotransferases;Physiological;Play;pre-clinical;Pre-Clinical Model;precision medicine;Predisposition;protein degradation;protein folding;protein function;Protein Kinase Interaction;Proteins;Proteolytic Processing;proteostasis;Purkinje Cells;Quality Control;Reaction;Receptor-Interacting Protein;Regulation;response;RIPK1 gene;Role;selective expression;sensor;Signal Pathway;Signal Transduction;small molecule;Spinocerebellar Ataxias;Stress;stressor;System;Testing;Tissues;Ubiquitin;ubiquitin ligase

PROJECT_TITLE: Protein quality control in age-related diseases

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The proposed study has the potential to improve patient outcomes by comparing two scalable smoking cessation interventions in a health system setting that will reach a large number of older adults who are at high risk for tobacco-related diseases. By delivering evidence-based and practical smoking cessation interventions in conjunction with lung cancer screening, participants may be especially amenable to receiving support for quitting. Results from this study, including a short-term economic analysis, budget impact, and feasibility data, will provide critical data to address future implementation within this and other large health systems.

PI_NAMEs: TAYLOR, KATHRYN L (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, ANNETTE R

PROJECT_TERMS: Abstinence;Acceleration;acceptability and feasibility;Accounting;Address;arm;barrier to care;budget impact;Bupropion;care delivery;Caring;Cessation of life;Cigarette;Clinical;clinical practice;Collaborations;compare effectiveness;contextual factors;cost;Cost Analysis;cost effective;Counseling;Data;design;Disease;Disparity;disparity reduction;economic evaluation;economic outcome;Effectiveness;Effectiveness of Interventions;effectiveness outcome;effectiveness testing;Electronic Health Record;Electronic Mail;Eligibility Determination;Enrollment;ethnic minority population;Ethnic Origin;evidence base;flexibility;Future;future implementation;Goals;Guidelines;Health;Health system;high risk;implementation framework;implementation strategy;improved;incremental cost;Individual;innovation;Insurance Coverage;Intervention;intervention cost;Leadership;Life;Lung;lung cancer screening;Malignant neoplasm of lung;Mediator;Methods;models and simulation;motivational enhancement therapy;nicotine replacement;Nurse Practitioners;older adult;Outcome;outreach;Participant;participant enrollment;Patient Schedules;Patient-Focused Outcomes;Patients;Population Heterogeneity;Practical Robust Implementation and Sustainability Model;primary outcome;Provider;quitline;Race;racial minority population;Randomized;randomized trial;Readiness;Recommendation;recruit;relapse prevention;Research;routine practice;screening;screening guidelines;Site;Smoke;Smoker;smoking cessation;Smoking Cessation Intervention;Specialist;Subgroup;sustainability framework;Systems Integration;Telephone;Text;therapy design;Tobacco;Training;Translations;Treatment Effectiveness;trial enrollment;Underinsured;Underserved Population;uptake;varenicline;Work

PROJECT_TITLE: Providing Tobacco Treatment to Patients Undergoing Lung Cancer Screening at MedStar Health: A Randomized Trial

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE Emergent literature shows that pregnant populations and their infants are at greater risk for adverse health and environmental effects from climate change. Few studies have examined the impacts of climate change on leading maternal and infant complications (e.g., gestational diabetes, severe maternal morbidity, hypertensive disorders of pregnancy, preterm birth); and even fewer have examined prenatal exposure to temperature extremes in the context of other social environmental stressors (e.g., residential segregation and poverty). The proposed project will examine prenatal exposure to extreme heat and cold events on excess maternal and infant health risk to provide much-needed foundational knowledge on the relationship between a changing climate and pregnancy risk and potential interventions.

PI_NAMEs: RUNKLE, JENNIFER D. (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Academy;Affect;age group;American;Attention;Birth;Characteristics;Child;Climate;climate change;climate crisis;climate impact;climate-related health;Clinic;cohort;Cohort Studies;college;Communities;cost;critical period;Data Analyses;Death Rate;design;Discipline of obstetrics;Disparity;efficacy evaluation;Environmental Exposure;Environmental Risk Factor;environmental stressor;Event;evidence based guidelines;Exposure to;extreme heat;extreme temperature;extreme weather;Gender;Generations;Gestational Diabetes;Goals;Gynecology;Health;health disparity;Health protection;Heat Waves;Human;Hypertension;improved;in utero;Infant;Infant Health;innovation;Intervention;Joints;Knowledge;Life;Light;Literature;Maternal Health;Maternal Mortality;Measures;Mental disorders;Monitor;neonatal health;Outcome;Pathway interactions;Patients;Pediatrics;Policies;Population;population based;Population Study;Population Surveillance;Poverty;Predisposition;Pregnancy;pregnancy disorder;pregnant;Premature Birth;prenatal;prenatal exposure;Public Health;public health intervention;Reporting;Research;residential segregation;resilience;response;Risk;Science;severe maternal morbidity;social;Social Environment;social factors;social health determinants;social stressor;sound;stressor;Subgroup;trend;United States;United States National Institutes of Health;Urbanization;Vulnerable Populations;Woman;Work;World Health Organization

PROJECT_TITLE: Impact of prenatal exposure to climate stressors and severe maternal morbidity: a retrospective birth cohort study

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioids;Pediatric;Social Determinants of Health;Substance Misuse

ORG_CITY: BLOOMINGTON

ORG_NAME: CHESTNUT HEALTH SYSTEMS, INC.

ORG_STATE: IL

PHR: PROJECT NARRATIVE Justice-involved emerging adults (EAs; aged 18-25) are one of the highest-risk populations for opioid and other substance use and other significant problems (criminal behaviors), but they lack access to and engagement in evidence-based practices. The deleterious outcomes and long-term costs of substance use for EAs, communities, and society (estimated at over $740 billion annually and greater than costs for any other health problem), make this a priority. The overarching purpose of the proposed study is to investigate an increasingly common, but under-researched, practice of employing paraprofessional coaches to improve EAs’ access to and engagement in evidence-based substance use practices, focusing on the paraprofessional coaches’ outcomes and the role of lived experience.

PI_NAMEs: DRAZDOWSKI, TESS K. (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Acceleration;Address;Adherence;age group;aged;American;Applied Skills;Belief;Bioethics;career;career development;Cessation of life;Client;Clinical Psychology;Communities;Complex;Consolidated Framework for Implementation Research;contingency management;cost;criminal behavior;design;Development;developmental psychology;Drops;Drug usage;Education;Educational workshop;Elements;emerging adult;Employment;Epidemic;Ethics;evidence base;Evidence based practice;experience;Future;Goals;Grant;Health;Health Services;Health Services Research;high risk;high risk population;human subject protection;implementation science;Improve Access;improved;Individual;Injury;innovation;Intervention;intervention delivery;Justice;Knowledge;Lead;lectures;Lived experience;Measurement;Medical;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methodology;Methods;Monitor;novel;Opiate Addiction;Opioid;opioid epidemic;opioid overdose;opioid use;Outcome;outpatient programs;parole;peer;peer support;Performance;Population;premature;probation;programs;Public Health;Qualitative Methods;Qualitative Research;Randomized;randomized, clinical trials;recidivism;Recovery;reduced substance use;relapse risk;Reporting;Research;research and development;Research Methodology;Research Personnel;Risk Factors;Role;Sampling;Scientific Advances and Accomplishments;service programs;service providers;Services;skills;societal costs;Societies;Source;Statistical Methods;statistics;substance use;substance use treatment;success;symposium;Symptoms;System;Testing;Time;Training;Training Activity;unintended pregnancy;Vertebral column;Vocation;Vulnerable Populations;Work;Writing

PROJECT_TITLE: Reducing Opioid and Other Drug Use in Justice-Involved Emerging Adults using Paraprofessional Coaches (with and without Lived Experience) to Deliver Effective Services in a Non-Treatment Setting

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]