NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: LOWELL

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

ORG_STATE: MA

PHR: Project Narrative Candida-associated denture stomatitis (CADS) is a common, recurring disease that impacts the oral health and overall well-being of denture wearers, especially those who are older and/or immunologically/medically compromised. This project will use a layer-by-layer self-assembly technique to coat multiple layers of natural salivary anticandidal peptides/proteins onto denture materials, for long-term management of CADS, which will reduce drug toxicity and minimize the risk of Candida resistance. This technology also has potential application on next generation medical devices (e.g., catheters, endotracheal tubes) to decrease biofilm formation, infections, and provide a safer healthcare environment.

PI_NAMEs: SUN, YUYU  (contact);YEH, CHIH-KO

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: 3-Dimensional;Adhesions;Affect;Animal Testing;Animals;anti-fungal agents;anti-microbial peptide;antimicrobial;Appearance;Azoles;Binding;Biological Assay;biomaterial compatibility;Candida;candida biofilm;Catheters;Charge;Clinical;Coculture Techniques;Computer-Aided Design;Computer-Assisted Manufacturing;Dentistry;Denture Stomatitis;Denture Wear;Dentures;Deposition;Dimensions;Disinfection;Drug Exposure;Drug toxicity;edentulism;efficacy evaluation;Elderly;endotracheal;Environment;Epithelial Cells;Epithelium;Family;Glycosaminoglycans;Goals;Health;Healthcare;histatin 5;histidine-rich proteins;Human;Hyaluronic Acid;Immunocompetent;Immunologics;In Vitro;in vivo;Infection;infection rate;innovation;Lactoferrin;mechanical properties;Mechanics;Medical;Medical Device;methacrylic acid;Microbial Biofilms;microorganism;Modeling;Mucins;mutant;National Institute of Dental and Craniofacial Research;next generation;Nosocomial Infections;novel;nutrition;Oral;oral bacteria;Oral health;oral infection;Outcome;Patients;Peptides;Personal Satisfaction;Plant Resins;Polyenes;Polymers;polymethacrylic acid;polypeptide;pre-clinical;preclinical efficacy;prevent;Preventive;Property;Proteins;Quality of life;Rattus;Recurrent disease;Research;Resistance;Resistant candida;response;risk minimization;Saliva;Salivary;salivary histatins;self assembly;Speech;Surface;Systemic infection;Techniques;Technology;Testing;Therapeutic;Time;Tooth structure;Toxic effect;Tube;Variant;Work

PROJECT_TITLE: Salivary peptide/protein-based multilayer denture coatings for controlling Candida biofilm formation and denture stomatitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 AC (15)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative More than 20,000 people in the United States are diagnosed with myeloproliferative neoplasms every year. Currently, we lack the tools to identify which patients will progress to acute leukemias and the only existing cure is allogeneic bone marrow transplant, a risky procedure that is feasible in only a small subset of the patients. Here, we propose a comprehensive research program to characterize individual cancer cells and reconstruct the history of disease progression in each patient, ultimately, identifying patient-specific targeted therapies that eradicate the cancer cells or hinder their growth.

PI_NAMEs: HORMOZ, SAHAND  (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Acute leukemia;Allogeneic Bone Marrow Transplantation;Animal Model;Blood;Blood Cells;Bone Marrow;Bone marrow biopsy;cancer cell;cancer stem cell;Cell division;Cells;Cicatrix;Data;Development;Diagnosis;Disease;Disease Outcome;disease phenotype;Disease Progression;DNA;Engineering;Erythrocytes;Genetic Transcription;genome sequencing;Genotype;Growth;Hematopoietic Neoplasms;hematopoietic stem cell expansion;Hematopoietic stem cells;Heritability;Heterogeneity;Individual;individual patient;JAK2 gene;Malignant Neoplasms;Measurement;Molecular;mouse model;Mutate;Mutation;Myeloproliferative disease;Nucleotides;patient subsets;Patients;Persons;Phenotype;Platelet Count measurement;Population;Procedures;programs;Recording of previous events;Research;Resolution;Somatic Mutation;stem cells;Symptoms;targeted treatment;technology platform;Testing;Tissues;tool;transcriptome;transcriptomics;Trees;tumor progression;United States;whole genome

PROJECT_TITLE: Tracing the lineage histories and differentiation trajectories of individual cancer cells in myeloproliferative neoplasms

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE: PUBLIC HEALTH RELEVANCE People living with dementia from racial-ethnic minoritized groups and socioeconomically disadvantaged environments are more likely to experience disparities in early diagnosis, treatment, quality of care, health outcomes, and access to end-of-life care. Our proposed project will use electronic health records data and machine learning algorithms to develop a personalized social risk management platform to improve the quality of care, well-being, and health equity among people living with dementia. Our long-term goal is to integrate social care into dementia clinical care, leading to a necessary paradigm shift in US health care delivery.

PI_NAMEs: BIAN, JIANG ;GUO, JINGCHUAN  (contact);SALLOUM, RAMZI GEORGE

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Advisory Committees;Affect;Age Years;Alabama;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Artificial Intelligence;artificial intelligence method;Behavioral;Caregivers;Caring;Characteristics;Clinical;clinical care;Clinical Research;cohort;Complex;Counseling;Data;Data Sources;Databases;Dementia;dementia care;design;Development;Diagnosis;Disease;Disparity;Documentation;Early Diagnosis;Electronic Health Record;electronic health record system;end of life care;Environment;Equity;ethnic minority population;Evaluation;experience;Face;falls;Fast Healthcare Interoperability Resources;Florida;Focus Groups;Food;food insecurity;Future;future implementation;Goals;Health;health care delivery;health data;health equity;health management;Healthcare;human old age (65+);implementation strategy;improved;Individual;innovation;Intervention;intervention mapping;Machine Learning;machine learning algorithm;machine learning model;Measures;Medical;meetings;member;Methodology;Methods;Minnesota;Natural Language Processing pipeline;Neighborhoods;New York;Outcome;Pathway interactions;patient oriented;Patients;Personal Satisfaction;Persons;Physical environment;pragmatic trial;preference;Process;programs;prototype;Psychological Factors;Public Health;public health relevance;Quality of Care;Quality of life;racial minority population;Recommendation;Risk;Risk Management;screening;Services;social;Social Environment;social health determinants;Social intelligence;socioeconomic disadvantage;Structure;Subgroup;success;Testing;text searching;tool;Universities;Update;user centered design;walkability;Work

PROJECT_TITLE: iSMART: intelligent Social risk Management in AD/ADRD paTients

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) are common particularly in Black and low-income populations. New anti-amyloid medications have demonstrated efficacy, but also raise challenges including adverse events as well as diagnostic, monitoring, delivery, transportation, and financial burdens, which may be particularly problematic in vulnerable populations. In this project, we will determine the effectiveness and cost-effectiveness of anti-amyloid medications in Black, low-income populations.

PI_NAMEs: CALLAGHAN, BRIAN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Adherence;Aducanumab;Adverse event;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Black Populations;Black race;blood pressure reduction;Brain;Caregivers;Cerebral Edema;Cerebrum;Characteristics;Clinical Trials;community academic partnership;community engagement;comparative cost effectiveness;cost;cost effectiveness;Coupled;Data;Data Set;Databases;Decision Making;Dementia;dementia risk;Diagnosis;Diagnostic;Disease;Effectiveness;effectiveness evaluation;evidence base;experience;Financial Hardship;Frequencies;Grant;health care disparity;health disparity;health equity;Health equity research;Healthcare;Hemorrhage;High Prevalence;high risk;high risk population;Hospitalization;Impaired cognition;improved;Incidence;Infusion procedures;Intervention;Interview;Intravenous infusion procedures;Low income;Low Income Population;Medicaid;Medicare;Methods;Michigan;mild cognitive impairment;Modeling;Modification;Monitor;Monte Carlo Method;mortality;Outcome;patient engagement;patient oriented;Patients;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;Policies;Population;Population Heterogeneity;Poverty;preference;Prevalence Study;Quality-Adjusted Life Years;racial population;Reporting;Research;Resources;Risk;screening;Severities;success;Surveys;Transportation;Uninsured Medical Expense;United States Department of Veterans Affairs;vascular risk factor;Veterans;Vulnerable Populations;Work

PROJECT_TITLE: Health Equity in Alzheimer’s Treatment (HEAT)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M4)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Within the United States’ opioid crisis, Black individuals face rapidly increasing rates of overdose death yet significant disparities in access to treatment. The current project will use geospatial technology to identify social determinants of health that underlie opioid overdose death among Black individuals. It will provide a model that can be replicated in localities across the country that face increasing racial inequities in opioid overdose death to guide culturally-relevant prevention and ultimately reduce opioid morbidity and mortality among Black Americans.

PI_NAMEs: BANKS, DEVIN  (contact)

PROGRAM_OFFICER_NAME: HAEGERICH, TAMARA

PROJECT_TERMS: access disparities;addiction;Address;Area;Black American;Black Populations;Black race;career;career development;caucasian American;Characteristics;Cities;Clinical Investigator;Communities;community advisory board;community based participatory research;Community based prevention;community engagement;Community Health;Community Health Aides;community intervention;Coroner;Country;Data;Death Rate;Decision Analysis;density;deprivation;design;Deterioration;Development;Development Plans;digital;digital health;digital tool;Disparity;effectiveness testing;Ensure;Environment;Environmental Impact;Ethnic Population;Evidence based treatment;experience;Face;Feedback;Fentanyl;Focus Groups;Future;Geographic Information Systems;Geography;Goals;Growth;Harm Reduction;Health;health equity;Health Personnel;Health Services Accessibility;high risk;implementation science;improved;Income;indexing;Individual;Inequality;Inequity;Institution;Intervention;manufacture;Maps;member;Methods;mhealth interventions;Missouri;Modeling;Morbidity - disease rate;mortality;Neighborhoods;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use;opioid use disorder;opioid user;Outcome;outreach;Overdose;overdose death;Overdose reduction;Overdose reversal;overdose risk;peer;Policies;Policy Maker;prevent;Prevention;programs;psychoeducation;racial disparity;Racial Equity;racial minority population;Recovery;Research;Research Personnel;Resource-limited setting;response;Risk;social;social health determinants;social interventions;software systems;structural health determinants;Structural Racism;Structure;substance use;Substance Use Disorder;substance use treatment;Technology;technology platform;tool;Training;training opportunity;treatment and outcome;Trust;Underserved Population;United States;Universities

PROJECT_TITLE: An Integrated Geospatial and Community-based Model to Prevent Opioid Overdose among Black Americans

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Nanotechnology;Neurosciences

ORG_CITY: AMHERST

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative Adeno-associated virus (AAV)-mediated gene therapy for inherited retinal dystrophies is finally a clinical reality. However, AAV therapies are expensive, limited by gene size, and randomly integrate in the host genome. This proposal hypothesizes that a combination of self-amplifying and self-circularizing mRNAs can increase mRNA stability, decrease immunogenicity, and provide proof-of-principle that mRNA is a viable gene therapy approach.

PI_NAMEs: FARKAS, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;adeno-associated viral vector;Affect;Anti-sense RNA;Area;Benchmarking;Biological Availability;cell type;Cells;circular RNA;Clinical;Clinical Trials;Codon Nucleotides;cost;cost effective treatment;CRISPR therapeutics;CRISPR/Cas technology;Data;Dependovirus;Development;Engineering;Exhibits;Exonuclease;Eye;Foundations;Future;gene augmentation therapy;gene therapy;Genes;Genome;genome editing;Immune response;immunogenicity;improved;In Vitro;in vitro Model;in vitro testing;in vivo;in vivo evaluation;Inherited;innovation;interest;Interferons;intravitreal injection;Introns;Investigation;Length;lipid nanoparticle;Literature;Longevity;Mediating;Messenger RNA;Methods;Modality;Modeling;mRNA delivery;nanoparticle delivery;new technology;novel;Nucleotides;Organ;Peptide Signal Sequences;Plasmids;Proteins;Rattus;Recombinant adeno-associated virus (rAAV);Retina;Retinal Detachment;Retinal Dystrophy;Retinal Ganglion Cells;Risk;RNA;RNA amplification;RNA Splicing;RNA Stability;RNA, Messenger, Splicing;Route;RPE65 protein;side effect;Specificity;Sprague-Dawley Rats;stability testing;Standardization;subretinal injection;Techniques;Technology;Testing;Therapeutic;therapeutic development;therapeutic RNA;Tissues;Transgenes;Translating;Translations;vaccine development;vector;Vision

PROJECT_TITLE: Utilizing circular, self-amplifying RNAs for prolonged expression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Sensitive Treponema pallidum genome recovery through tiling amplicon sequencing Genomic epidemiology is now a routine part of the public health response to pathogen outbreaks. Here, we propose to design and validate a tiling amplicon sequencing approach for complete genome recovery from Treponema pallidum, the causative agent of syphilis. Amplicon tiling approaches recently enabled the sequencing of >16 million SARS-CoV-2 genomes and we expect these methods will allow for more sensitive and rapid recovery of T. pallidum sequencing in laboratories across the world.

PI_NAMEs: GRENINGER, ALEXANDER L (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: Antimicrobial Resistance;Applications Grants;Attention;authority;Bacteria;Binding;bioinformatics pipeline;case finding;Characteristics;cis-female;Clinical;clinical sequencing;Congenital Syphilis;Consensus;Consumption;cost effective;cost effectiveness;County;COVID-19 pandemic;Data;design;Diagnosis;Diagnostic;Disease Outbreaks;DNA;Ensure;experimental study;Failure;Genbank;Gene Frequency;Generations;Genome;genomic epidemiology;Genomics;Gonorrhea;HIV;improved;Incidence;infancy;interest;Investments;Knowledge;Laboratories;Libraries;Methodology;Methods;Microbiology;Molecular;Molecular Analysis;molecular diagnostics;Monitor;Monkeypox virus;operation;Organism;outbreak response;outreach;pathogen;pathogen genome;pathogenic bacteria;Patients;Performance;Population Surveillance;prevent outbreaks;Procedures;Protocols documentation;Public Health;Reaction;Reagent;Recovery;Research;response;Sampling;SARS-CoV-2 genome;Sexually Transmitted Diseases;Shotgun Sequencing;Specificity;Specimen;Syphilis;Testing;Time;transmission process;Treponema pallidum;United States;Update;Validation;Variant;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 FDS-M (M1)]


NIH_SPENDING_CATS: Genetics;Human Genome;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Chronic parenchymal lung diseases including idiopathic pulmonary fibrosis (IPF), other adult interstitial lung diseases (ILD) and bronchopulmonary dysplasia (BPD) are among the leading causes of morbidity and mortality in the US and around the world, yet there is little in the way of disease-modifying therapies for these conditions. We hypothesize that disrupted cellular signaling leads to dysfunction of critical specialized cellular functions in the lung alveolus, leading to progressive lung pathology and declining lung function. In this LungMAP3.0 Research Center, we will use state-of-the-art spatial transcriptomic and single-cell multiomic approaches to investigate the mechanisms that underlie the initiation and progression of IPF, other ILDs and BPD and test therapies aimed at restoring alveolar homeostasis.

PI_NAMEs: BANOVICH, NICHOLAS ELI;KROPSKI, JONATHAN ANDREW (contact);SUCRE, JENNIFER MALCOLMSRYGLEY

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Adult;advanced disease;Age;age related;Alveolar;alveolar homeostasis;Antibodies;Atlases;Automobile Driving;Back;Biology;Bronchopulmonary Dysplasia;Cell Physiology;cell type;Cells;Chronic;Chronic Disease;Chronic lung disease;chronic respiratory disease;Clinical;cohort;Collaborations;Communication;Communities;Data Coordinating Center;data sharing;Development;Disease;Disease Progression;Distal;Functional disorder;Gene Expression;Genetic Transcription;Genomic approach;Goals;Homeostasis;Human;human tissue;idiopathic pulmonary fibrosis;Image;innovation;insight;intercellular communication;Interruption;Interstitial Lung Diseases;Knowledge;Lead;life span;Lung;lung development;Lung Diseases;Machine Learning;Maintenance;Mediating;Microspheres;Modeling;Molecular;Molecular Analysis;Molecular Evolution;molecular pathology;Molecular Target;Morbidity - disease rate;mortality;multiple omics;Natural History;neonatal lung injury;novel;novel therapeutics;Organogenesis;Organoids;Pathologic;Pathology;Pathway interactions;Pattern;Peptides;Phenotype;Positioning Attribute;pre-clinical;prevent;Productivity;programs;Pulmonary alveolar structure;Pulmonary Fibrosis;pulmonary function;pulmonary function decline;Pulmonary Pathology;reconstruction;Recording of previous events;Research;Research Personnel;Resolution;restoration;Risk;Risk Factors;Sampling;Series;Signal Transduction;single cell genomics;Slice;small molecule;Specific qualifier value;Stimulus;Structure of parenchyma of lung;System;Testing;Therapeutic;Tissues;transcriptomics

PROJECT_TITLE: Unraveling the molecular origins of chronic parenchymal lung diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (M1)]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Federated learning is a technique that allows researchers to build common machine learning models without sharing data. However, current implementations present challenges related to bias, data heterogeneity, data privacy, and interoperability among institutions. We propose new mathematical and algorithmic approaches to make federated learning a practical reality in biomedical research by developing domain- specific add-on algorithms that leverage techniques such as optimal transport and secure multiparty computation to overcome statistical and algorithmic bias and privacy concerns.

PI_NAMEs: GURSOY, GAMZE  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Address;Adopted;Adoption;algorithmic bias;Algorithms;biomedical informatics;Biomedical Research;Bridge to Artificial Intelligence;Clinical;Clinical Data;clinical decision support;Collaborations;computer science;Computer software;cost;cryptography;Data;data access;data curation;data harmonization;data privacy;Data Security;Data Set;data sharing;Deterioration;Disease;Ensure;Evaluation;federated data;federated learning;Goals;Grouping;Health;Healthcare;Heterogeneity;heterogenous data;Hospitals;insight;Institution;interoperability;Knowledge;Label;Lead;Learning;learning algorithm;Machine Learning;machine learning model;Mathematics;Medical;Medical center;Medicine;Metadata;Methodology;Methods;model building;Modeling;Molecular;multiple datasets;Nature;New York;Outcome;Participant;patient population;patient privacy;patient subsets;Patients;Pattern;Physiological;Population;predictive modeling;Presbyterian Church;Preservation Technique;Privacy;privacy preservation;privacy protection;Privatization;Process;Rare Diseases;Research;Research Personnel;response;Rights;Sample Size;Secure;Security;Site;Statistical Bias;Statistical Distributions;statistics;Techniques;tool;training data;Translating;Work

PROJECT_TITLE: Federated learning algorithms to overcome statistical and algorithmic bias and privacy concerns in machine learning for health

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Aging;Climate-Related Exposures and Conditions;Clinical Research;Health Services;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Identifying modifiable factors that can improve nursing home resident outcomes after exposure to severe weather events is relevant to both public health and to the emerging priorities of the National Institute on Aging. By linking administrative compliance and health data with geospatial data classifying exposure to Hurricane Michael, the proposed research will quantify the relative importance of federal emergency preparedness standards to nursing home resident outcomes and empirically evaluate mechanisms (effect modification and mediation) by which compliance with these standards could affect post-disaster resident outcomes. The findings from the proposed work will elucidate opportunities for regulators and nursing home staff to intervene upon the factors that render residents most susceptible to adverse outcomes after severe weather events.

PI_NAMEs: FESTA, NATALIA  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Administrator;adverse outcome;Affect;aging population;Atmosphere;Characteristics;Classification;Climatology;Clinical;Code;Contracts;Data;Data Set;Disasters;emergency preparedness;Emergency response;Environmental Hazards;Event;Excess Mortality;Exposure to;Fire - disasters;functional decline;Geography;Health;health data;Hospitalization;Hurricane;improved;Individual;Infection Control;Knowledge;Licensing;Life;Link;Literature;Measures;Mediating;Mediation;Medical;Modification;Morbidity - disease rate;mortality;National Institute on Aging;non-compliance;Nursing Homes;Outcome;Ownership;Policies;Positioning Attribute;predictive modeling;Predisposition;Privatization;Public Health;Quality Control;Readiness;Research;Retrospective cohort study;Risk;risk stratification;Safety;Sampling;severe weather;Surveys;United States Centers for Medicare and Medicaid Services;Wildfire;Work

PROJECT_TITLE: Investigating Nursing Home Emergency Preparedness for Environmental and Climatological Determinants of Resident Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-R (M1)]


FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

PI_NAMEs: MAGARATI, RATNA MAYA;PARKER, MYRA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: OUDEKERK, BARBARA ANN

PROJECT_TERMS: Academy;Acceleration;Address;Affective;Agreement;Alaska Native;Alaska Native population;alcohol abuse therapy;Alcohol consumption;Alcohols;American Indian Population;American Indians;Area;base;Behavior Therapy;behavioral health;Canada;Clinical;clinical training;Cognitive;Collaborations;Communication;Communities;community based participatory research;comorbidity;Complex;Conceptions;Country;Cultural Diversity;cultural values;Data;data access;Data Analyses;Data Collection;data quality;data sharing;data visualization;design;Development;digital;Dimensions;Documentation;Educational Curriculum;Educational process of instructing;Effectiveness;Elderly;Ensure;Environment;Environmental Impact;Epidemic;Epistemology;Etiology;Evaluation;Evidence based intervention;experience;Exposure to;Face;Faculty;Fostering;Funding;Gift Giving;Goals;Grant;Ground Substance;Guidelines;Harm Reduction;healing;Health;Health behavior;health disparity;health equity;health inequalities;health management;Health Status;Helping to End Addiction Long-term;holistic approach;improved;Indigenous;indigenous community;Individual;Inequity;Information Dissemination;Infrastructure;innovation;Institution;Institutional Policy;instructor;International;Intervention;Intervention Studies;Knowledge;knowledge integration;Language;Lead;Leadership;Learning;Linguistics;Lived experience;Manuals;Maps;Measures;Medicine;meetings;member;Mental Health;Mentors;Methodology;Methods;Modeling;Monitor;mortality;Motivation;multimodality;National Institute of Drug Abuse;Native Americans;Nepal;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid overdose;opioid use disorder;Outcomes Research;Overdose;overdose prevention;Overdose reduction;Ownership;Pain;pain behavior;Pain management;Pain Research;Participant;Perception;Personal Satisfaction;Personality;Persons;Policies;Population;Poverty;Prevention;Prevention approach;Prevention Research;Procedures;Process;professor;programs;protocol development;Protocols documentation;Public Health;Publications;Readiness;reduced substance use;Relationship-Building;Reporting;Research;Research Design;Research Ethics;research in practice;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;Resource Sharing;Resources;response;Risk;Role;Sampling;scaffold;Science;Series;Site;skills;social;Societies;Speed;Spirituality;stimulant use disorder;student training;Students;substance use;Substance Use Disorder;substance use prevention;summer program;summer research;targeted treatment;Technology;Temperament;Testing;Time;tool;Training;transition to adulthood;Translating;Translations;Trauma;tribal community;tribal leader;tribal member;Tribally Based Participatory Research;Tribes;Trust;Unemployment;United States National Institutes of Health;Universities;Update;urban Native American;virtual;Washington;webinar;Work;Writing

PROJECT_TITLE: GATHER: Growing a Tribal Healing Effort through Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 OTHR-6 (01)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Neurosciences;Stroke;Substance Misuse

ORG_CITY: SHREVEPORT

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: Project Narrative Our research is focused on uncovering the detrimental effects of chronic heavy alcohol consumption on the brain. Specifically, we are investigating how alcohol disrupts normal brain function, leading to an increased risk of stroke and cognitive decline to understand and develop effective prevention strategies and treatments

PI_NAMEs: PANCHATCHARAM, MANIKANDAN  (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: 3' Untranslated Regions;Address;Adult;Affect;Alcohol consumption;alcohol effect;alcohol exposure;Alcoholism;Alcohols;Behavioral trial;Binding;Biological;Biological Models;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier disruption;BMX gene;Brain;brain endothelial cell;cell type;cerebrovascular;Cerebrovascular system;Cessation of life;Chronic;Clinical;Cytoskeletal Proteins;Data;disability;Endothelial Cells;Endothelium;Enzymes;Equilibrium;fluorescence imaging;Foundations;Functional disorder;Genetic Suppression;Histologic;Homeostasis;Hydrolysis;Impaired cognition;Impairment;improved;Induced Neurons;Inflammation;inhibitor;Injury;Knock-out;Knockout Mice;Link;lipid phosphate phosphatase;Lipids;lysophosphatidic acid;Lysophosphatidylcholines;Magnetic Resonance Imaging;Mediating;Microglia;Middle Cerebral Artery Occlusion;mimetics;Mitochondria;Molecular;morris water maze;Mus;Near-infrared optical imaging;neuroinflammation;Neurologic Deficit;neuron apoptosis;neuron loss;neuroprotection;novel;nuclear factors of activated T-cells;object recognition;offspring;Outcome;oxidant stress;Oxidation-Reduction;Oxidative Stress Induction;Pathway interactions;pharmacologic;Phase;Play;pre-clinical;Prevention strategy;Production;promoter;Protein Dephosphorylation;Reactive Oxygen Species;Regulation;Reperfusion Therapy;Reporting;Research;Rho-associated kinase;Risk Factors;Role;Signal Transduction;Source;Stress;Stroke;stroke risk;Superoxide Dismutase;targeted treatment;Testing;Therapeutic;Tight Junctions;transcription factor;Translations;Vascular Diseases;Vascular Endothelial Cell;viral rescue

PROJECT_TITLE: Unraveling the Mechanisms of Alcohol-Induced Blood-Brain Barrier Disruption: A Focus on Lysophosphatidic Acid Signaling and Endothelial Cells.

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric;Prevention

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Early adolescence is a high-risk time for deterioration of blood glucose levels in young people with type 1 diabetes (T1DM). This application will assess the feasibility, acceptability and preliminary effects of an intervention that incorporates the structured care of a pet fish into a family-based diabetes self-care routine combined with communication skills training on glycemic control, blood glucose monitoring frequency and blood glucose review in early adolescents with T1DM and elevated blood glucose levels. It is expected that the proposed study will provide information to guide a subsequent larger multi-site randomized clinical trial to evaluate efficacy of the intervention.

PI_NAMEs: GUPTA, OLGA THERESA (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: acceptability and feasibility;Adherence;Adolescence;Adolescent;Behavior;Blood Glucose;Caregivers;Caring;Child;Child Care;Chronic;Clinical;Clinical Trials;Collaborations;Communication;Competence;Control Groups;cost;Cues;Data;Deterioration;Development;Diabetes Mellitus;diabetes self-management;Documentation;early adolescence;Economics;Educational Intervention;Educational Status;efficacy evaluation;efficacy trial;Eligibility Determination;Ensure;experience;Family;Feedback;Fishes;follow-up;Fostering;Frequencies;glucose monitor;glycemic control;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Habits;Hemoglobin concentration result;high risk;Home;improved;innovation;Instruction;Insulin-Dependent Diabetes Mellitus;Intervention;intervention effect;Maintenance;Measures;novel strategies;Outcome;parental involvement;parental monitoring;Parents;Participant;patient population;Persons;Population;Randomized;randomized, clinical trials;recruit;Reporting;Research;Resources;response;retention rate;routine care;Sample Size;Self Efficacy;Self Management;Site;skills;skills training;social cognitive theory;Structure;success;Surveys;Systems Theory;Testing;theories;Time;Training;treatment as usual;Treatment Efficacy;trend;Youth

PROJECT_TITLE: Impact of Integrated Pet Care on Glycemic Control and Diabetes Responsibility

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: Narrative Millions of older adults receive care in intensive care units (ICUs) annually. However, because there are few evidence-based interventions designed to help ICU clinicians themselves provide primary palliative care to patients, we developed ICUconnect—a mobile app-based intervention for clinicians and family members—and found in a pilot trial that it reduced palliative care needs. This proposal aims to test the intervention’s efficacy in a diverse population and to understand how other hospitals can best implement it in the future

PI_NAMEs: COX, CHRISTOPHER ETHAN (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Address;Adherence;Admission activity;Affect;Age;Alabama;Area;Black race;care delivery;care outcomes;Caring;Characteristics;Clinical;clinical care;Clinical Trials;Communication;comorbidity;Complex;Critical Care;Critical Illness;culturally appropriate intervention;Data;deprivation;design;digital;disadvantaged background;disparity reduction;Effectiveness of Interventions;effectiveness/implementation design;efficacy evaluation;efficacy testing;Eligibility Determination;Ensure;Environment;ethnic diversity;ethnic minority;Ethnic Origin;Evidence based intervention;experience;Family;Family member;Financial Hardship;follow-up;Future;future implementation;Geography;Geriatrics;Goals;Health;health care disparity;health care settings;health equity;Health Technology;Healthcare;Heterogeneity;Hospitals;Hybrids;implementation framework;implementation intervention;implementation measures;Implementation readiness;improved;indexing;Infrastructure;innovation;Intensive Care Units;Intervention;intervention delivery;Interview;Language;Latin American;Linguistics;Measurement;Medical;meetings;Methods;mobile application;Modeling;multidisciplinary;older adult;Outcome;Palliative Care;Participant;participant interview;Patient Self-Report;Patients;person centered;pilot trial;Population;Population Characteristics;Population Heterogeneity;post intervention;primary outcome;provider communication;provider factors;psychological distress;Quality of Care;Race;racial diversity;racial minority population;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Reporting;Research;Role;routine care;Rural;rurality;Sampling;secondary outcome;Self Efficacy;Severity of illness;Site;social;social factors;Social support;South Carolina;Spanish;Spanish Americans;Specialist;Structure;Subgroup;success;Symptoms;Target Populations;Testing;therapy design;treatment as usual;treatment effect;Treatment Efficacy;treatment response;Universities;Work

PROJECT_TITLE: Improving needs among older adults: the ICUconnect 2 primary palliative care RCT

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE In-hospital cardiac arrest is a significant public health concern, affecting approximately 292,000 Americans each year, with a survival rate to hospital discharge as low as 18.8%. Although Black patients exhibit a lower survival rate than White patients, the reasons for this health inequity remain unclear. This proposal aims to evaluate racial and ethnic differences in patient outcomes and intra- arrest care processes in order to identify specific areas that can be improved to mitigate the health inequity following in-hospital cardiac arrest.

PI_NAMEs: OKUBO, MASASHI  (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Acute;Adult;Affect;American;American Heart Association;Applications Grants;Area;authority;black patient;Black race;Caring;Categories;Cerebrum;Circulation;Clinical;comorbidity;Data Set;Death Rate;demographics;Disparity;Education;Electric Countershock;Ensure;Epinephrine;ethnic difference;ethnic disparity;Ethnic Origin;Exhibits;experience;functional outcomes;Goals;Guidelines;hazard;health care disparity;Health Disparities Research;health disparity;health inequalities;Healthcare Systems;Heart Arrest;Hispanic;Hospitals;implicit bias;improved;indexing;Intervention;Knowledge;Link;Logistic Models;Measures;Mediating;Mediation;Methods;Modeling;mortality;Odds Ratio;Outcome;outcome disparities;Patient-Focused Outcomes;Patients;Performance;Phase;premature;Process;prospective;Public Health;Race;racial difference;racial disparity;Registries;Reporting;Research;Resuscitation;Shock;Source;Statistical Models;Survival Analysis;survival outcome;Survival Rate;Time;United States

PROJECT_TITLE: Racial and ethnic disparities in patient outcomes and intra-arrest resuscitation practices for in-hospital cardiac arrest

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Lymphatic Research;Neurosciences;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Los Angeles

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Craniosynostosis is a craniofacial disorder with brain structural and neurocognitive defects. This proposal investigates how mesenchymal stem cell (MSC) implantation can mitigate elevated intracranial pressure and brain defects in craniosynostosis. The outcome will help develop an effective treatment for this devastating congenital disease.

PI_NAMEs: CHEN, JIANFU  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Age;Animal Experimentation;Animal Model;Automobile Driving;Behavior;Behavioral;Biocompatible Materials;Biological Markers;Birth;blood lead;Blood Vessels;bone;Brain;brain dysfunction;brain volume;Calvaria;Cells;cerebral vein;Cerebrospinal Fluid;Cerebrovascular Circulation;Chotzen Syndrome;Chronic;Clinic;clinical practice;clinical translation;Cognitive;Cognitive deficits;Complex;Congenital Disorders;constriction;craniofacial disorder;Craniosynostosis;cranium;Data;Defect;Development;Disease;Drainage procedure;Dysmorphology;effective therapy;efficacy evaluation;Exhibits;Functional disorder;Goals;Growth;Hemorrhage;Human;Image;Impairment;Implant;implantation;improved;innovation;Intracranial Hypertension;Joint structure of suture of skull;Knowledge;Lead;Legal patent;Lymphatic function;lymphatic vessel;Magnetic Resonance Imaging;Meningeal;Meningeal lymphatic system;Meninges;Mesenchymal Stem Cells;minimally invasive;Mus;Mutant Strains Mice;Names;Natural regeneration;neglect;Neurocognitive;Neurocognitive Deficit;neurogenesis;Neurologic;Neurologic Deficit;Neurological Models;neuronal growth;neuronal survival;novel;operation;Operative Surgical Procedures;Outcome;Pathologic;Patients;Positioning Attribute;pre-clinical;premature;Prevalence;prevent;prognostic tool;Publishing;Recurrence;Rejuvenation;Repeat Surgery;Risk Factors;scaffold;Signal Transduction;Site;stem cell therapy;stem cells;Structural defect;Structure;Surgical sutures;suture fusion;Testing;Therapeutic;therapy development;transcription factor;Transforming Growth Factor beta;TWIST1 gene;Validation;white matter;white matter injury

PROJECT_TITLE: MSC implantation as a treatment for developmental brain defects in craniosynostosis

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE  This proposal aims to renew and build upon the established Harmonized Cognitive Assessment Protocol (HCAP) International Research Network. Currently, fifteen longitudinal studies of aging have used the HCAP and several more intend to. By promoting common approaches to HCAP data harmonization and support of researchers using the data, the HCAP network will expand the resources and opportunities for studying AD/ADRD around the world.

PI_NAMEs: KOBAYASHI, LINDSAY C;LANGA, KENNETH M (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Affect;Africa South of the Sahara;Aging;aging biomarker;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Behavioral;Biological Markers;cardiovascular risk factor;Classification;cognitive function;cognitive testing;Collaborations;Communities;comparative;Consultations;Country;Data;Data Collection;data harmonization;Dedications;Dementia;dementia risk;design;Diagnostic;diagnostic algorithm;Diet;Economics;Education;Education and Outreach;Educational Activities;Educational workshop;epidemiology study;Family Study;flexibility;Funding;Genetic;Geography;Goals;Health and Retirement Study;Individual;insight;Institution;instrument;International;Leadership;Life Cycle Stages;Linguistics;Longitudinal Studies;Measures;meetings;Methods;National Institute on Aging;next generation;older adult;Outcome;Persons;Pilot Projects;pilot test;Policies;Population;population based;Population Study;Prevalence;protective factors;Protocols documentation;Research;Research Personnel;Research Priority;Resource-limited setting;Resources;response;Retirement;Role;Sampling;Sampling Studies;Scientist;Site;social;Structure;success;Testing;Variant;virtual;web site

PROJECT_TITLE: Research Network for the Harmonized Cognitive Assessment Protocol (HCAP): Years 6-10

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-L (A2)]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Internal targeted radionuclide therapy uses radioactive drugs to destroy tumors and can also be applied for imaging or diagnostic applications. From a therapeutic perspective, those that emit a specific form of radiation called alpha particles are highly effective and have been the subject of many promising clinical trials within recent years, but are generally not amenable for imaging. This project will develop new chemistry to enable the highly efficacious alpha-emitting drugs to be used in conjunction with identical radioactive imaging agents, leading to substantial improvements in patient treatment and diagnosis.

PI_NAMEs: WILSON, JUSTIN J (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Actinium;Actinoid Series Elements;Address;Alpha Particle Emitter;Alpha Particles;Area;Beta Particle;Binding;Biodistribution;Biological;Bismuth;cancer cell;cancer therapy;Chelating Agents;chelation;chemical property;Chemicals;Chemistry;Clinic;Clinical;clinical development;Clinical Research;Clinical Trials;Complex;cytotoxic;design;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Discipline of Nuclear Medicine;Disease;dosimetry;Drug Approval;Drug Industry;Drug Kinetics;Exhibits;Fluorine;Funding;Half-Life;human disease;Image;imaging agent;improved;in vivo;Indium-111;interest;Ions;Lead;Ligands;Linear Energy Transfer;Metals;Modality;Nature;Nuclear Decay;overexpression;patient response;Patients;Penetration;Pharmaceutical Preparations;Photons;Positron;prevent;Property;Radiation;Radiation therapy;Radioactive;Radioisotopes;Radiolabeled;Radionuclide Imaging;Radionuclide therapy;Radiopharmaceuticals;Radium;receptor;response;Staging;success;System;theranostics;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapy design;translational potential;Treatment Efficacy;tumor;Uranium;Vanadium;vector;Work

PROJECT_TITLE: Chelators to Enable Theranostic Alpha Particle Radiotherapeutic Agents

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

PHR: Project Narra�ve To advance the science of AD/ADRD risk, resilience, and disparities, the proposed Gateway Exposome Coordinating Center (GECC) will bring together experts and stakeholders to identify exposome research priorities, develop harmonized exposome measures based on those priorities, and establish guidance and best practices for their use. By engaging stakeholders and bringing together expertise across broad domains of exposures, including the climate, physical environment, social environment, policy environment, community services environment, and life experiences, the GECC will facilitate interdisciplinary research to achieve a better understanding of how different components of the exposome relate to each other and interact to influence AD/ADRD outcomes. Through an inclusive and transparent curation of exposome data for research, the GECC will lower the efforts required by individual researchers or stakeholders to capture diverse exposomes over the life course and make high-quality harmonized measures and guidance freely and publicly available, maximizing benefits to the AD/ADRD research community.

PI_NAMEs: ADAR, SARA ;KNAPP, DAVID MICHAEL KEITH;LEE, JINKOOK  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: academic program;Acceleration;Advisory Committees;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Climate;Cognition;cognitive testing;Collaborations;Communication;Communities;Community Services;Consensus;Country;Data;Data Discovery;data platform;data resource;Decision Making;dementia risk;Development;Discipline;Disparity;Documentation;Educational workshop;Environment;Event;Exhibits;Exposure to;extreme temperature;fine particles;Fostering;Funding;Future Generations;Goals;hackathon;Health and Retirement Study;Individual;Infrastructure;innovation;Interdisciplinary Study;interest;International;Interview;Lead;Life Cycle Stages;Life Experience;life history;Link;Long-Term Care;Measurement;Measures;Methodological Studies;Methodology;multidisciplinary;novel;Outcome;Output;Peer Review;Persons;Physical environment;Policies;Population;Professional Organizations;programs;Protocols documentation;Publications;Publishing;Recommendation;Recording of previous events;Research;Research Infrastructure;Research Personnel;Research Priority;Research Support;resilience;resilience factor;Resource Sharing;Resources;Risk Factors;Science;social;Social Environment;social media;Source;Structure;synergism;tool;United States National Institutes of Health;virtual;Vision;web site;webinar

PROJECT_TITLE: Gateway Exposome Coordinating Center (GECC) For AD/ADRD Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M3)]


NIH_SPENDING_CATS: Asthma;Breastfeeding, Lactation and Breast Milk;Data Science;Genetics;Lung;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Nutrition;Pediatric;Prevention;Women's Health Research

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This project will combine large birth cohorts, state-of-the-art algorithms, and animal models to elucidate the intricate mechanisms through which breastfeeding and microbial colonization modulates childhood respiratory health outcomes years in advance. Our study will revolutionize the way breastfeeding and early-life microbial colonization are studied and understood and will provide a foundation for the development of robust microbiome- based asthma predictors and targets for primary prevention.

PI_NAMEs: SHENHAV, LIAT  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adaptive Immune System;Adolescent;Affect;Age;Algorithms;Animal Model;Asthma;Birth;Breast Feeding;Characteristics;Child;Childhood;Childhood Asthma;Chronic Disease;Clinical;cohort;Computing Methodologies;Data;Development;diagnostic tool;dimension reduction;Disease;Etiology;Family;Foundations;Genetic;Grant;Growth;gut microbiome;gut microbiota;Health;Heterogeneity;host-microbe interactions;Human Microbiome;Human Milk;Hypersensitivity;immune function;Immune response;in vivo Model;Infant;Infant Health;Innate Immune System;innovation;insight;interest;Investigation;Joints;Life;Link;longitudinal dataset;Longitudinal Studies;Lung;Machine Learning;metabolomics;metagenomic sequencing;Metagenomics;Microbe;microbial;microbial colonization;microbial community;Microbial Genetics;microbiome;microbiota;Modeling;Morbidity - disease rate;mortality;Multiomic Data;multiple omics;nasal microbiome;novel;Outcome;Pathogenesis;Pattern;Phenotype;Play;Population Genetics;Predisposition;Pregnancy;Prevalence;Prevention strategy;Primary Prevention;Process;Prospective Studies;Regulation;Reproducibility;Reproducibility of Results;Research;Resistance;respiratory;Respiratory Disease;respiratory health;respiratory microbiome;respiratory microbiota;Respiratory Tract Infections;Risk;Risk Reduction;Role;Sampling;Shotguns;Study models;Taxonomy;Techniques;Time;Time Series Analysis;tool;unsupervised learning;Variant;Weaning

PROJECT_TITLE: BREATH - Breastfeeding, Early-life Microbiome and Respiratory Health Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-D (M1)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Respiratory disease accounts for over $170 billion/year in health care costs in the United States, and globally chronic respiratory diseases are the 5th and 6th leading cause of death and disability. The URMC- BRINDL(NL) Human Tissue Core continues to be a cornerstone of the multi-center LungMAP effort to develop a multi-dimensional molecular, cellular, and structural atlas of normal, and entering into Phase III, diseased human lung from preterm birth through adulthood, in an ultimate effort to identify mechanisms, novel and more effective treatments, and prevention of lung disease.

PI_NAMEs: PRYHUBER, GLORIA S (contact)

PROJECT_TERMS: Adult;Affect;Age;Asthma;Atlases;Awareness;biobank;Bioinformatics;Biological Assay;Biology;Biopsy;Bronchopulmonary Dysplasia;Budgets;Cataloging;Catalogs;Cause of Death;cell type;Cells;Child;Childhood;chronic respiratory disease;Clinical Data;Collaborations;Communities;Consensus;cost;COVID-19 pandemic;COVID-19 pneumonia;Data;data management;Databases;Dedications;Development;Digital Imaging and Communications in Medicine;Dimensions;disability;Disease;Drug or chemical Tissue Distribution;effective therapy;Ensure;Equipment and supply inventories;Ethnic Origin;Exclusion;experience;Funding;Funding Opportunities;Generations;Goals;Health Care Costs;High Resolution Computed Tomography;Human;Human BioMolecular Atlas Program;human disease;human tissue;Image;image archival system;improved;Informatics;Informed Consent;Infrastructure;Investigation;Knowledge;Lead;Lung;lung development;Lung Diseases;Medical;Medical center;Mental Health;Metadata;Molecular;new therapeutic target;Nomenclature;novel;Online Systems;Ontology;Organ;Pathogenicity;Pathway interactions;Perinatal;Phase;Policies;Portal System;postnatal human;Premature Birth;premature lungs;preservation;Preservation Technique;Prevention;Procedures;Process;Productivity;Program Development;pulmonary hypoplasia;Rare Diseases;reconstruction;Recovery;repository;Research;Research Personnel;Resolution;Resources;Respiratory Disease;Respiratory Tract Diseases;response;Retrieval;Sampling;Source;Specimen;Standardization;Structure;Structure of parenchyma of lung;success;symposium;System;Techniques;Technology;Tissue Banks;Tissue imaging;tissue processing;Tissues;United States;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: BioRepository for INvestigation of Diseases of the Lung  (BRINDL) - Phase III


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE The goal of this study is to understand the role of CEBPA mutations in the pathobiology of acute myeloid leukemia. Specifically, we are studying how CEBPA mutations (AML) block differentiation of myeloid cells, to cause an accumulation of immature myeloid blasts characteristic of this deadly disease. Understanding how CEBPA mutations impair differentiation through alteration of chromatin architecture and activation of cellular signaling pathways will help create a mechanist foundation for the development of more efficacious therapies to treat patients with AML.

PI_NAMEs: MAXSON, JULIA E (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;Alleles;Antibodies;Architecture;ATAC-seq;Binding;Binding Proteins;Blood;Bone Marrow;Cell Differentiation process;cell growth;Cell Separation;Cells;Characteristics;Chromatin;Cleavage Under Targets and Release Using Nuclease;Data;Development;Disease;Distal;effective therapy;efficacious treatment;Enhancers;Equilibrium;Exhibits;experimental study;follow-up;Follow-Up Studies;Foundations;Functional disorder;Gene Expression;Genes;Genetic Transcription;Genomic Segment;Genomics;Global Change;Goals;Grant;Granulocyte Colony-Stimulating Factor Receptors;Growth Factor Receptors;Hematologic Neoplasms;Hematopoietic;hematopoietic differentiation;Histones;Hour;Impairment;inhibitor;knock-down;Ligands;loss of function mutation;MAP Kinase Gene;Mass Spectrum Analysis;Methods;Modeling;Mouse Cell Line;mutant;Mutation;myeloblast;Myelogenous;Myeloid Cells;Myeloid Leukemia;novel;Outcome;Pathway interactions;Patients;pharmacologic;Phenotype;phosphoproteomics;Phosphorylation;PI3K/AKT;Proliferating;promoter;Proteins;receptor;Receptor Activation;Regulation;Regulatory Element;Relapse;Research;Role;Running;Signal Pathway;Signal Transduction;small hairpin RNA;STAT3 gene;Stat5 protein;stem cell proliferation;tandem mass spectrometry;Therapeutic;Time;transcription factor;transcriptome sequencing;Tyrosine Phosphorylation;Western Blotting

PROJECT_TITLE: Aberrant STAT Function in CEBPA-mutant Acute Myeloid Leukemia

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Nutrition;Obesity;Prevention

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND VA MEDICAL RESEARCH/ED/FDN

ORG_STATE: OH

PHR: Atrial Fibrillation is the most common arrhythmia in the United States. There is a critical need to investigate the clinical effectiveness of new cardiometabolic drugs, repurposing potential of old diabetic drugs and bariatric surgery in the management of atrial fibrillation.

PI_NAMEs: SAHADEVAN, JAYAKUMAR ;SUNDARAM, VARUN  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Ablation;Address;adult obesity;Agonist;Alcohol abuse;Anti-Arrhythmia Agents;Anti-Inflammatory Agents;Arrhythmia;Atrial Fibrillation;bariatric surgery;Body Weight decreased;Cardiac ablation;cardiometabolic risk;cardiometabolism;Cardiovascular system;Cessation of life;Clinical effectiveness;clinically relevant;cohort;Comparative Effectiveness Research;cost;Data;design;Development;Diabetes Mellitus;diabetic;diabetic patient;Dose;Drug usage;Electric Countershock;Electronic Health Record;Epidemiology;Event;Exhibits;FDA approved;follow-up;Future;GLP-I receptor;Glucose;Health system;Heart failure;high risk;Hospitalization;Hypertension;Impairment;Incidence;inhibitor;insight;Life Style;Longterm Follow-up;Maintenance;Metabolic;Metabolic syndrome;Metformin;middle age;Modification;mortality;Obesity;Outcome;Patients;Pharmaceutical Preparations;Population;Pragmatic clinical trial;Prevalence;Primary Prevention;Procedures;Process;Progressive Disease;Property;prospective;Public Health;Publishing;Quality of life;randomized trial;recruit;Recurrence;Reporting;response;restoration;Risk;Risk Factors;Role;Safety;Sample Size;Secondary Prevention;Sinus;Sodium;stroke risk;Suspensions;symporter;Therapeutic;Time;Treatment Failure;treatment risk;United States;United States Department of Veterans Affairs

PROJECT_TITLE: Metabolic therapy for atrial fibrillation

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE  Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) often go undiagnosed or are diagnosed after substantial delays, leading to undertreatment and delays in care. This project will derive a novel AD/ADRD classification to accurately quantify AD/ADRD diagnostic errors and delays that disproportionately affect racial and ethnic minority groups and underserved populations, and to measure the impact on health care utilization and costs. The findings will inform health care policy and public health efforts to reduce disparities in diagnosis and care, improve health outcomes, and reduce avoidable health care costs for people living with dementia and their caregivers.

PI_NAMEs: HUDOMIET, PETER  (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Address;Admission activity;Affect;Age;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;beneficiary;Blood Vessels;care costs;care systems;Caregivers;Caring;Characteristics;Chronic;Classification;Code;Cognitive;comorbidity;cost;cost comparison;cost estimate;Cost Measures;Data;Data Set;Dementia;Diagnosis;Diagnostic;Diagnostic Errors;Disease;disease diagnosis;Disparity;Disparity in diagnosis;disparity reduction;Drug usage;Economics;Emergency department visit;ethnic disparity;ethnic minority population;Ethnic Origin;Ethnic Population;family burden;Family member;Fee-for-Service Plans;General Population;Grant;Growth;Health;Health and Retirement Study;Health Care Costs;health care service utilization;Health Policy;health record;Healthcare;Hospitalization;human old age (65+);improved;Individual;International Classification of Disease Codes;International Classification of Diseases;Knowledge;Link;Literature;Measures;Mediator;Medicaid;Medical;Medicare;Medicare claim;Methodology;Methods;Minority Groups;Modeling;mortality;novel;novel strategies;Nursing Homes;older adult;Outcome;Patients;Persons;Pharmaceutical Preparations;Policy Making;Population;Prevalence;programs;Public Health;Race;racial disparity;racial minority;racial minority population;racial population;Records;Research;residence;Role;Rural Population;rural underserved;Services;sex;Social support;Specific qualifier value;Subgroup;Therapeutic;Underserved Population;Uninsured;Uninsured Medical Expense;Urban Population;Urbanicity;Work

PROJECT_TITLE: Disparities in undiagnosed and misdiagnosed dementia and the impact on health care utilization and costs - a novel approach using probabilistic dementia classifications

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-8 (M4)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative Skeletal muscle diseases are debilitating and therapeutic options sparce. The goal of this project is to explore new strategies to enhance delivery of therapeutic material to skeletal muscle by harnessing the activity of endogenous fusogenic proteins.

PI_NAMEs: MILLAY, DOUGLAS PAUL (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Animal Model;Capsid Proteins;Cell fusion;cell type;Cells;Cellular Membrane;Characteristics;Clinical Trials;Complement;Complex;Data;delivery vehicle;Dependovirus;Development;Dose;Duchenne muscular dystrophy;Dystrophin;Engineering;env Gene Products;Event;Exhibits;extracellular vesicles;Fibroblasts;gene correction;gene therapy;Genes;Genetic;Genetic Materials;genetic payload;Goals;Homing;Human;immunogenic;improved;In Vitro;in vivo;insight;Intramuscular;Knowledge;Lentivirus;Ligands;Location;Mediating;Membrane;Membrane Fusion;Membrane Proteins;Methods;micro-dystrophin;Modality;Molecular;mouse model;Muscle;Muscle Cells;Muscle Development;Muscle Fibers;Muscle function;muscle progenitor cell;Muscular Dystrophies;Musculoskeletal Diseases;Mutate;Mutation;Myopathy;Natural regeneration;Non-Viral Vector;novel;Outcome;particle;Pathology;Process;Productivity;Property;protein function;Proteins;receptor;reconstitution;restoration;Serotyping;Skeletal Muscle;stem cells;Surface;System;Testing;Therapeutic;Tissues;treatment strategy;Tropism;vector;Viral;Virion;Virus;virus tropism

PROJECT_TITLE: Development and optimization of skeletal muscle delivery vehicles

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Data Science;Precision Medicine

ORG_NAME: NEW YORK UNIVERSITY

PI_NAMEs: COOK, STEPHANIE HAZEL (contact)

PROGRAM_OFFICER_NAME: ALFARANO, ALEXANDRIA SKYE

PROJECT_TERMS: All of Us Research Program;American;Area;Awareness;Bioinformatics;Biology;Biomedical Research;career;cohort;Collaborations;Communities;computer science;cooking;Data;Data Analyses;data cleaning;data management;Data Science;Data Set;Development;disability;Discipline;Doctor of Philosophy;doctoral student;early-career faculty;Educational workshop;Electronic Health Record;Equity;equity, diversity, and inclusion;Evaluation;evidence base;experience;Faculty;faculty mentor;fitbit;Gender;Goals;graduate student;Head;Health Personnel;Hispanic-serving Institution;Historically Black Colleges and Universities;Individual;innovation;Institution;interest;Justice;knowledge integration;large scale data;mathematical sciences;member;Methodology;Methods;mid-career faculty;minority investigator;minority undergraduate;Minority-Serving Institution;New York;novel strategies;Occupations;outreach;Pathway interactions;Postdoctoral Fellow;pre-doctoral;programs;Psychology;Public Health;Pythons;Race;recruit;Research;Research Methodology;Research Personnel;Research Training;Resource Sharing;Resources;response;Scientist;Sex Orientation;Site;skills;social;Sociology;statistics;Students;summer program;Time;Training;Training Programs;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;Universities;usability;web site;webinar;Work

PROJECT_TITLE: Building a Diverse Network to Support and Build Pathways for Historically Underrepresented Students in Quantitative-Focused Research Areas Within the All of Us Research Program


ORG_CITY: WASHINGTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Obesity causes multiple complications including hypertension and sleep apnea, which contribute to high cardiovascular morbidity and mortality. In the parent grant, we have discovered a novel mechanism of these diseases related to signaling of leptin in the carotid body. In this supplement, we will test if an important component of the leptin pathway, melanocortin 4 receptor in the carotid body, is involved in the development of hypertension and sleep apnea in obesity.

PI_NAMEs: POLOTSKY, VSEVOLOD Y (contact);SHAM, JAMES SK;STOCKER, SEAN D

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Adipocytes;Attenuated;Blood Pressure;Breathing;cardiovascular effects;Cardiovascular system;career;Carotid Body;carotid sinus;Cations;Cells;Chronic;Clinical Trials;comparison control;Data;Development;diet-induced obesity;Disease;Doctor of Philosophy;Energy Metabolism;Future;Genetic;Genetic Transcription;Health;Hormones;Hypertension;Hypoxia;Inbred SHR Rats;knock-down;Leptin;leptin receptor;Ligands;Melanocortin 4 Receptor;member;Metabolic;Morbidity - disease rate;mortality;Mus;Nerve;novel;Obese Mice;Obesity;parent grant;Pathway interactions;Patients;Peer Review;Peptides;pharmacologic;posttranscriptional;prevent;Pro-Opiomelanocortin;Protein Isoforms;receptor;receptor expression;Receptor Signaling;Reflex action;Research;Research Personnel;respiratory;response;Role;sensor;Signal Transduction;Sleep Apnea Syndromes;small hairpin RNA;Testing;Transcription Process;Transcriptional Activation;Work;α-Melanocyte stimulating hormone

PROJECT_TITLE: Melanocortin 4 signaling in the carotid body in obesity

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Although neuroactive steroids (NAS) and the gamma-aminobutyric acid-A receptor (GABAAR) are thought to be involved in the serious affective disorder premenstrual dysphoric disorder (PMDD), comprehensive studies in humans are lacking. We propose to study the concentrations of GABAergic NAS and ratios of NAS to their precursors, expression of the rate-limiting neurosteroidogenic enzymes, and expression of GABAAR subunits across the luteal phase in controls and PMDD, and within PMDD among those who receive a low-dose selective serotonin reuptake inhibitor (SSRI) versus placebo. The results will provide a comprehensive view of the dynamic changes in these systems across the menstrual cycle and will add to our understanding of the mechanisms that underlie PMDD, as well as therapeutic mechanisms of the first-line PMDD treatment, low- dose SSRI.

PI_NAMEs: HANTSOO, LIISA VICTORIA (contact);PINNA, GRAZIANO

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: Affect;Allopregnanolone;Biological;Biology;Blood;Blood Cells;Brain Diseases;Categories;comparison control;Data;Disease;Dose;Drug Modulation;Enrollment;Enzymes;experience;external ear auricle;Functional disorder;Future;gamma-Aminobutyric Acid;Goals;Hormones;Hour;Human;Hydroxysteroid Dehydrogenases;Impairment;International;Interview;Isomerism;Knowledge;Laboratory Finding;Light;Luteal Phase;Mass Fragmentography;Measures;Medicine;Menstrual cycle;Menstruation;Methods;Mood Disorders;mood symptom;Moods;Morbidity - disease rate;neuropsychiatry;neurosteroids;Outcome;Outcome Measure;Ovulation;Oxidoreductase;Participant;Pathway interactions;personalized medicine;Phase;placebo controlled trial;placebo group;Placebos;Plasma;Polymerase Chain Reaction;positive allosteric modulator;Postpartum Depression;Pregnanolone;premenstrual dysphoric disorder;Progesterone;programs;Prospective Studies;Psychiatry;Randomized;randomized placebo controlled trial;receptor;receptor function;reduce symptoms;reproductive;Research;Research Personnel;Resistance;response;Selective Serotonin Reuptake Inhibitor;Sertraline;Serum;Site;standard care;steroid hormone;Symptoms;System;Therapeutic;therapy development;Time;treatment response;Universities;Virginia;Vulnerable Populations;Whole Blood;Woman;Women's study;women's treatment

PROJECT_TITLE: 1/2 Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-M (60)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Liver Disease

ORG_NAME: LIVER INSTITUTE NORTHWEST PLLC

PHR: PROJECT NARRATIVE Metabolic associated steatotic liver disease (MASLD) and metabolic associated steatohepatitis (MASH) are increasingly common and contribute to substantial morbidity and mortality in the USA. The NASH Clinical Research Network (NASH CRN) will continue to conduct clinical and translational research that will advance our knowledge of the pathogenesis, natural history, management and outcomes of MASLD and MASH with a goal to improve the clinical care and treatment of patients with MASH.

PI_NAMEs: KOWDLEY, KRIS  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Adult;biobank;Cells;Child Development;Childhood;clinical care;clinical center;Clinical Research;clinical research site;Clinical Treatment;clinical trial implementation;Clinical Trials;Conduct Clinical Trials;Data;Data Analyses;Databases;Deposition;design;Development;Disease;Enrollment;Ensure;Epidemiology;Fibrosis;follow-up;Funding;Genetic;Genetic Transcription;Geographic Locations;Goals;Health;Hepatic;improved;International;Iron;Knowledge;Leadership;Liver;Liver diseases;liver injury;Metabolic;metabolic-associated fatty liver disease;Mission;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Outcome;Paper;participant enrollment;Pathogenesis;patient population;patient retention;Patients;Pharmaceutical Preparations;Productivity;programs;Protocols documentation;Publications;Publishing;Research;Reticuloendothelial System;Role;Severity of illness;Site;Steatohepatitis;success;Translational Research;Visit;Work

PROJECT_TITLE: Clinical Research Network in Nonalcoholic Steatohepatitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-6 (M2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Chronic Pain;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Palliative Care;Physical Injury - Accidents and Adverse Effects;Prescription Drug Misuse;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The 2016 CDC guidelines on opioid prescribing were intended to reduce the inappropriate use of opioids, but little is known about their unintended impact on legitimate opioid prescribing. Those who may have been unintentionally affected by these guidelines include diverse racial/ethnic minorities, the economically disadvantaged, and older adults with Alzheimer’s and related dementias (ADRD) who have a pain-associated condition, such as cancer or falls-related orthopedic fracture. This GEMSSTAR will identify the association of the 2016 CDC opioid guidelines with disparities in opioid-based pain management for either cancer or orthopedic fracture among three vulnerable subgroups of community-dwelling Medicare beneficiaries– those with ADRD, those experiencing poverty, and those identifying as racial/ethnic minoritized individuals.

PI_NAMEs: RODIN, REBECCA ANNE (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acceleration;Acute Pain;Adult;Affect;Alzheimer's disease related dementia;Analgesics;beneficiary;Cancer Model;Cause of Death;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Chronic;Chronic Cancer Pain;chronic painful condition;Clinical;Communities;Data;Dementia;deprivation;design;Diagnosis;Disparity;economic disparity;end of life;Ensure;Equity;ethnic disparity;ethnic minority;ethnic minority population;Event;evidence base;experience;fall injury;falls;Family;Fee-for-Service Plans;Fracture;Future;Guidelines;Health;Heart failure;high risk;Hip Fractures;Hip region structure;illicit opioid;Income;Individual;Link;long bone;Longitudinal Surveys;Malignant Neoplasms;Medical;medically necessary care;Medicare;Medicare Part A;Medicine;Modeling;non-cancer pain;older adult;Opioid;opioid epidemic;opioid mortality;opioid policy;Orthopedics;Overdose;Pain;Pain management;pain model;Participant;Patient Self-Report;Pelvis;pelvis fracture;Persons;Pharmacy facility;physical impairment;Policies;Population;Poverty;prescription opioid;Prescription opioid overdose;Prevention Guidelines;Publications;Publishing;Quality of life;racial disparity;racial diversity;racial minority;Recommendation;Records;Reporting;Research;Respondent;response;Risk;Sampling;sociodemographics;socioeconomic disparity;socioeconomics;Subgroup;Supportive care;Surveys;Time;Trauma;Traumatic injury;United States;Well in self

PROJECT_TITLE: Dementia and the opioid epidemic: The impact of the 2016 CDC guidelines on disparities in pain management

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-R (M1)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Suicide;Suicide Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Culturally grounded mental health prevention interventions hold significant promise to reduce suicide among American Indian/Alaska Native (AI/AN) youth, a group at highest risk in the nation. However, there is little research to understand how core components included in these interventions impact mental health outcomes and promote resiliency against suicide. The proposed study with White Mountain Apache Tribe research partners will focus on an innovative, culturally grounded AI youth suicide prevention intervention, “The Elders’ Resilience Curriculum,” to: a) identify core components that impact protective factors against suicide; b) develop a youth resilience theoretical model; c) culturally adapt measures to assess outcomes; and d) pilot a culturally acceptable and rigorous evaluation to inform future research and scaling of this intervention to other AI/AN communities.

PI_NAMEs: O’KEEFE, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Adolescent;Adolescent Development;Affect;Age;Alaska Native;American Indians;Apache;Apache Tribe;Belief;career;Cherokee Indian;Child;Clinical;Communities;community based participatory research;cultural values;Disparity;Educational Curriculum;effectiveness study;Elderly;Evaluation;experience;Goals;Health;high risk;improved;Indigenous;innovation;Intervention;Language;Life;Measures;Mental Health;Mental health promotion;Mental Health Services;Mentored Research Scientist Development Award;Mentorship;Methods;National Institute of Mental Health;native youth;Outcome;Outcome Assessment;prevent;Prevention;preventive intervention;programs;promote resilience;protective factors;Public Health;reducing suicide;Research;Research Methodology;Research Personnel;Research Support;resilience;Resources;Risk;scale up;Schools;Science;Seminole Tribe;Specific qualifier value;Suicide;Suicide prevention;Testing;Theoretical model;therapy design;Training;tribal college;Tribal Elders;Tribes;Underserved Population;White Mountain Apache;Youth

PROJECT_TITLE: Admin Supplement: The Elders' Resilience Curriculum: Toward Building Empirical Evidence for a Culturally Grounded American Indian Youth Suicide Prevention Intervention


NIH_SPENDING_CATS: Genetics;Hematology;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Ribosomes are nanomachines responsible for all protein production within the cell, and different cell types contain different numbers of ribosomes. It is largely unknown how ribosome numbers are controlled in the cell types that make up the human blood system. We will re-analyze existing datasets to extract hidden information about ribosome production and numbers in human bone marrow, with the goal of gaining insight into the control of ribosome production in health and disease, and generating better therapies for marrow disorders.

PI_NAMEs: PARALKAR, VIKRAM R. (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Affect;Algorithms;Alleles;ATAC-seq;Atlases;Binding;Biogenesis;Bioinformatics;bioinformatics tool;Biological Assay;bisulfite sequencing;Blood;Bone Marrow;CEBPA gene;cell type;Cells;ChIP-seq;Chromatin;Chromosomes;CRISPR interference;Custom;Data;Data Set;design;Disease;DNA mapping;DNA Methylation;DNA Polymerase I;epigenome;falls;Genes;Genetic;Genetic Transcription;Genome;Goals;Guidelines;Health;Hematopoiesis;Hematopoietic;hematopoietic stem cell quiescence;Human;human data;in vivo;insight;K562 Cells;Kinetics;Libraries;Maps;Marrow;Messenger RNA;Methylation;Modeling;Molecular;Mus;Myelogenous;Myeloid Cells;nanomachine;Nature;novel;Pathologic;Physiological;Process;Production;progenitor;Proliferating;Proteins;Regulation;Repression;Retinal blind spot;Ribosomal DNA;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RNA;RNA Polymerase I;single-cell RNA sequencing;stem cells;System;tool;transcription factor;transcriptome;Translations;Trees;Variant;whole genome

PROJECT_TITLE: A map of ribosomal RNA regulation in human hematopoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infertility;Polycystic Ovary Syndrome (PCOS);Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE Polycystic ovary disease is a common disorder of reproductive-aged women and is associated with infertility and metabolic dysfunction. The contribution of polycystic ovary dysfunction to metabolic dysregulation is not fully defined, but may be driven by altered signaling by members of the transforming growth factor beta family (TGFβ), including anti-Müllerian hormone (AMH). Our goal is to use a novel SMAD variant discovered by the Rare and Atypical Diabetes Network (RADIANT) in a PCOS family to define how changes in SMAD signaling disrupts female fertility and promotes metabolic disease in non-reproductive tissues.

PI_NAMEs: PANGAS, STEPHANIE A. (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: aged;AMHR2 gene;Amino Acids;androgen excess;Androgens;Automobile Driving;Biochemical;bone loss;Bone Morphogenetic Proteins;Cardiovascular Diseases;Cellular Metabolic Process;Circadian Rhythms;Clinical Data;Cognition Disorders;college;Complex;Coupled;CRISPR/Cas technology;cytokine;Data;Daughter;Defect;design;Development;Diabetes Mellitus;Disease;disease phenotype;energy balance;Engineering;Environment;Etiology;experimental study;Family;female fertility;Fertility;Foundations;Functional disorder;Funding;Genetic Polymorphism;Genetic Risk;Genetic Transcription;Genitourinary system;genome wide association study;genomic data;Genus Hippocampus;Glycolysis;Goals;granulosa cell;Health;Heterozygote;Histology;Hormonal;Hormones;inclusion criteria;Infertility;inhibin B;insight;Insulin Resistance;insulin sensitivity;Irregular Menstruation;Knock-in;Knockout Mice;Knowledge;Ligand Binding;Ligands;Link;MADH4 gene;Malignant Neoplasms;Medicine;member;Menstrual cycle;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Metabolism;Mission;Mitochondria;mouse model;mullerian-inhibiting hormone;Mus;National Institute of Child Health and Human Development;Non obese;novel;Nuclear;Nuclear Translocation;nutrition;Obesity;oocyte quality;Oocytes;Organ;Outcome;Ovarian;ovarian dysfunction;Ovarian Follicle;Pathogenesis;Pathologic;Pathway interactions;Patients;Phenocopy;Phenotype;Phosphorylation;Plasma;Play;Polycystic Ovary Syndrome;Postmenopause;Production;programs;Property;Protein Isoforms;Proteins;Proteomics;Publishing;rare variant;receptor;Recombinant Proteins;Reproduction;reproductive;reproductive system disorder;Research;Research Priority;Resources;Respiration;Risk;risk variant;Role;Serum;Signal Transduction;Signaling Protein;Solid;Structural Models;System;Technology;Testing;therapeutic target;Tissues;transcription factor;Transcriptional Activation;Transforming Growth Factor beta;United States National Institutes of Health;Variant;Woman

PROJECT_TITLE: SMAD5 signaling in Polycystic Ovary Syndrome

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Biotechnology;Lung;Pulmonary Fibrosis

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Our overarching goal is to understand how fibrotic lung diseases arise and how they progress and we will therefore collect samples from these patients and analyze the individual cells in the tissue in their locations and study how they interact with one another. We will also examine what each of the cells is secreting and how this could drive progression of fibrosis. Lastly, we will use our human 3D model of lung fibrosis to test specific ways in which cell interactions might drive fibrosis.

PI_NAMEs: GOMPERTS, BRIGITTE N (contact);KOTTON, DARRELL N.;PLATH, KATHRIN

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Address;AGTR2 gene;airway epithelium;Alveolar;alveolar epithelium;Automobile Driving;Award;Basement membrane;biobank;bioinformatics pipeline;Biological Models;Biology;Biomedical Engineering;Bronchioles;Cell Adhesion;cell behavior;Cell Communication;Cell Compartmentation;Cell Culture Techniques;Cell model;Cell secretion;Cells;Cellular Assay;Chronic;chronic wound;Clinic;Coculture Techniques;Data;data exchange;Data Set;Development;Disease;disease model;Disease Progression;Distal;end stage disease;Epithelial Cells;Epithelium;experience;Extracellular Matrix;Fibroblasts;Fibrosis;fibrotic lung disease;follow-up;Gene Expression;Genes;Genetic Transcription;genome-wide;genomic data;Genomics;Goals;high risk;Human;In Situ;In Vitro;Individual;induced pluripotent stem cell;injured airway;Injury;innovation;Intercellular Junctions;interstitial;interstitial cell;Interstitial Lung Diseases;Lesion;Lesion by Stage;Link;Location;Lung;Lung Diseases;Mesenchymal;Modeling;MUC5B gene;multimodality;mutant;Mutation;nanoscale;novel;novel therapeutics;Organoids;paracrine;Pathway interactions;Patients;Phenotype;Process;programs;Progressive Disease;prospective;Protein Analysis;Proteins;Proteomics;Pulmonary Fibrosis;Pulmonary Surfactant-Associated Protein C;Regional Disease;Research;Respiratory Failure;response;Sampling;scaffold;Signal Transduction;Stress;Structure of parenchyma of lung;Techniques;Technology;Testing;three-dimensional modeling;Time;Tissue Banks;Tissues;transcriptomics;Variant;Work;wound healing

PROJECT_TITLE: Cell-cell and cell-matrix interactions driving progressive fibrosis in interstitial lung diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (M1)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Infectious Diseases

ORG_CITY: NORMAN

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: NARRATIVE Bacterial eye infections, including endophthalmitis and keratitis, frequently accompany eye surgery and contact lens wear. A growing number of such incidents fail to respond to the available antibiotic treatments and often lead to vision loss. This project seeks to develop a novel family of antibacterial agents against eye pathogens.

PI_NAMEs: RYBENKOV, VALENTIN V (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Address;Affect;Amines;Animals;Anti-Bacterial Agents;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Bacterial Chromosomes;Bacterial Eye Infections;Bacterial Model;Blindness;Cell Line;Cells;Chromatin;Chromosome Segregation;Chromosome Structures;Chromosomes;Collaborations;Complication;condensin;Contact Lenses;Cornea;Corneal Ulcer;Data;Development;Drug resistance;efficacy evaluation;Endophthalmitis;Eye;Eye Infections;Family;fitness;Fluoroquinolones;Formulation;Gene Expression;Gram-Negative Bacteria;Growth;Human;Impairment;In Vitro;in vivo Model;Infection;inhibitor;insight;Keratitis;Knowledge;Lead;Life Style;Methylation;Microbiology;Modeling;mouse model;Multi-Drug Resistance;Mus;novel;Operative Surgical Procedures;Ophthalmologic Surgical Procedures;Organism;pathogen;Peritonitis;Pharmaceutical Chemistry;Pharmaceutical Preparations;Physicians;Play;Preparation;Production;prospective;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Resistance;resistance mechanism;Role;screening;segregation;Series;small molecule inhibitor;stem;System;Testing;Therapeutic;Tissues;Toxic effect;transcriptomics;Virulence;Virulence Factors

PROJECT_TITLE: Chromosome Packing Inhibitors for the Treatment of Eye Infections

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Rare Diseases

ORG_CITY: TUCSON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: SUPPLEMENT SPECIFIC NARRATIVE Approximately 15 million people in the United States are at risk for developing cirrhosis, liver failure, hepatocellular carcinoma and death due to non-alcoholic steatohepatitis (NASH), while there are less than 10,000 liver transplants performed annually in the United States. This Research Supplement adds to the training of the diverse biomedical workforce and, in doing so, will develop novel cell and bioengineering-based platforms to investigate the effect of matrix stiffness in NASH. Together, the improved understanding of these underlying mechanisms will aid in the development of new treatments for NASH and progressive liver fibrosis and dysfunction.

PI_NAMEs: GREEN, RICHARD M;WERTHEIM, JASON A (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Award;Biomedical Engineering;career;career development;career networking;Cells;Cessation of life;Cirrhosis;Collaborations;Communication;Development;Disease;Education;Environment;experience;Fortification;Foundations;Functional disorder;Future;Goals;graduate student;Grant;Health;Hepatocyte;improved;Individual;induced pluripotent stem cell;inflammatory milieu;Joints;Laboratories;Liver;Liver Dysfunction;Liver Failure;Liver Fibrosis;liver transplantation;Malignant neoplasm of liver;meetings;Mentors;Mentorship;Modeling;Molecular;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Oral;parent project;Parents;Pathway interactions;Patients;Persons;Positioning Attribute;Primary carcinoma of the liver cells;Research;Research Personnel;Research Project Grants;response;Risk;Signal Pathway;skill acquisition;Solid;Structure;Techniques;Technology;tool;Training;United States;Writing

PROJECT_TITLE: Ex-vivo bioengineered technology to unravel dysfunction due to non-alcoholic steatohepatitis (NASH)

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Although neuroactive steroids (NAS) and the gamma-aminobutyric acid-A receptor (GABAAR) are thought to be involved in the serious affective disorder premenstrual dysphoric disorder (PMDD), comprehensive studies in humans are lacking. We propose to study the concentrations of GABAergic NAS and ratios of NAS to their precursors, expression of the rate-limiting neurosteroidogenic enzymes, and expression of GABAAR subunits across the luteal phase in controls and PMDD, and within PMDD among those who receive a low-dose selective serotonin reuptake inhibitor (SSRI) versus placebo. The results will provide a comprehensive view of the dynamic changes in these systems across the menstrual cycle and will add to our understanding of the mechanisms that underlie PMDD, as well as therapeutic mechanisms of the first-line PMDD treatment, low-dose SSRI.

PI_NAMEs: PAYNE, JENNIFER L (contact)

PROJECT_TITLE: 2/2 Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: Project Narrative The long-term care industry is one of the fastest growing sectors of the economy, but also creates some of the lowest-paid and lowest-quality jobs. Precarious working conditions are costly for workers – who are disproportionately women and women of color – and the patients they care for, who have a high prevalence of AD/ADRD. This project will estimate the impact of three economic policy levers – wages, unionization, and staffing regulations – on improving the lives of the dementia care workforce and their patients.

PI_NAMEs: COE, NORMA B (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Academy;Address;Alzheimer's Disease;Alzheimer's disease related dementia;Antipsychotic Agents;beneficiary;care recipients;Caring;Cessation of life;Characteristics;Communication;Communities;community based service;Continuity of Patient Care;Contracts;cost;COVID-19 pandemic;Data;Dementia;dementia care;Deterioration;Drug usage;economic disparity;Economic Policy;Emergency department visit;Employment;ethnic minority;ethnic minority population;Ethnic Origin;evidence base;Face;Family;functional status;Gender;Geography;Goals;Health;health care service utilization;health disparity;health equity;Health Personnel;Heterogeneity;High Prevalence;Home;Home Care Services;hospital readmission;Hospitalization;improved;Industry;instrument;Investments;Laws;Left;Long-Term Care;Measures;Medicaid;Mental Health;Methods;minority patient;mortality;Nursing Homes;Nursing Staff;Observational Study;Occupations;Outcome;pandemic disease;Patient Care;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;physical conditioning;Policies;policy recommendation;Population;Poverty;Quality of Care;Race;racial minority;racial minority population;Regulation;Reporting;Research Design;Rural;rural dwellers;rurality;SARS-CoV-2 infection;sex;Side;skills;success;Training;United States National Institutes of Health;Vulnerable Populations;Wages;welfare;Woman;women of color;Work;Workload;Workplace

PROJECT_TITLE: Strengthening the Dementia Care Workforce: Analyzing Economic Policies' influence on Workers and their Patients Living with Dementia


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Lymphatic Research;Lymphoma;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE NHL is the most common hematologic malignancy, and there are many unmet clinical and public health needs of this growing patient population. The goal of the LEO infrastructure grant is to support a cohort of over 16,000 non-Hodgkin lymphoma (NHL) patients in order to address broad and cutting-edge research that identifies clinical, epidemiologic (including lifestyle and other exposures), host genetic, tumor, and treatment factors, and the interaction among these factors, on short and long-term outcomes. The efforts of this Research Supplement are well aligned with the ultimate goal of identifying new approaches to improve the survival and well-being of NHL patients.

PI_NAMEs: CERHAN, JAMES R (contact);FLOWERS, CHRISTOPHER R

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: Address;Adolescent and Young Adult;African American;Age;Asian;biobank;Blood specimen;Cause of Death;Clinical;Clinical Data;clinical trial enrollment;Clinical Trials;Clinical Trials Network;cohort;Cohort Studies;Data;Development;Diagnosis;digital pathology;Disease Progression;DNA;Electronic Health Record;Enrollment;Environmental Exposure;Epidemiology;Ethnic Origin;follow-up;Formalin;Genetic;Germ Lines;Goals;Grant;Growth;Health;Hematologic Neoplasms;Hispanic;improved;Incidence;Informatics;Infrastructure;Life Style;Lymphoma;Malignant Neoplasms;Minority Groups;Newly Diagnosed;Non-Hodgkin's Lymphoma;non-Hodgkin's lymphoma patients;novel;novel strategies;Outcome;Paraffin Embedding;Participant;Pathology;pathology imaging;patient advocacy group;Patient Outcomes Assessments;patient population;Patients;peripheral blood;Personal Satisfaction;Persons;Plasma;Prognosis;prospective;public database;Public Health;Race;recruit;Relapse;Research;Research Priority;Research Project Grants;Resources;Retreatment;RNA;rural patients;Rural Population;Sample Size;Second Primary Cancers;Serum;Slide;Socioeconomic Factors;Survival Rate;Survivors;survivorship;Tissue Microarray;Tissue Sample;Treatment Factor;treatment strategy;trend;tumor;Tumor Bank;tumor DNA;Update

PROJECT_TITLE: The Lymphoma Epidemiology of Outcomes (LEO) Cohort Study (Diversity Supplement - Alexis Romero)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]