ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Cancer;Congenital Structural Anomalies;Data Science;Dental, Oral, and Craniofacial Disease;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narra+ve The research proposed in this project aims to signiﬁcantly enhance our understanding of the gene7c links between childhood cancers and structural birth defects, which are among the leading causes of pediatric morbidity and mortality. By leveraging advanced machine learning techniques to analyze extensive genomic data, this study will contribute to fundamental knowledge about the nature of these condi7ons and their underlying biological mechanisms. In the long term, this research has the poten7al to inform more eﬀec7ve diagnos7c and therapeu7c strategies, thereby improving health outcomes, prolonging life, and reducing the burden of illness and disability in aﬀected children and adults.

PI_NAMEs: DISKIN, SHARON ;GOLDMUNTZ, ELIZABETH ;SILVERSTEIN, JONATHAN C.;TAYLOR, DEANNE MARIE (contact)

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: Address;Adult;Affect;Age;algorithmic bias;Algorithms;analytical tool;Area;Automobile Driving;Benchmarking;Biological;Brain;Brain Neoplasms;burden of illness;Cells;Child;Childhood;Clinical;clinical application;cohort;Collaborations;Communities;community engagement;Complex;Congenital Abnormality;Congenital Heart Defects;Data;Data Analyses;Data Analytics;data ecosystem;data exploration;data integration;data interoperability;data reuse;Data Set;Dedications;Defect;design;Detection;Development;Diagnosis;dimension reduction;disability;Embryo;Embryonic Development;empowerment;Engineering;Ensure;Epidemiology;epidemiology study;Etiology;experience;Feedback;Funding;Future;Genetic;genomic data;Genomic Data Commons;Genomics;Genotype-Tissue Expression Project;Germ Lines;Germ-Line Mutation;Goals;Graph;graph database;graph neural network;Health;Hematologic Neoplasms;heterogenous data;Human BioMolecular Atlas Program;human data;Human Resources;improved;Incidence;Informatics;informatics tool;Infrastructure;innovation;insight;interoperability;Knowledge;knowledge graph;Lead;Level of Evidence;Life;Link;Machine Learning;machine learning method;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Methodology;Methods;Molecular Target;Morbidity - disease rate;mortality;multidisciplinary;Mus;Nature;Neuroblastoma;Observational epidemiology;Ontology;Outcome;Outcome Measure;Pediatric cohort;Pediatric Oncology;Principal Investigator;Protocols documentation;Quality Control;Recording of previous events;repository;Research;Research Personnel;Source;Structural Congenital Anomalies;Structure;success;Techniques;Testing;Tissues;tool;tumor;Update;user-friendly;Visualization;web site

PROJECT_TITLE: U24-Uncovering the Shared Genetic Origins of Childhood Cancer and Structural Birth Defects Through Enhanced Data Integration and Analysis with the CFDE Data Distillery Knowledge Graph.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-E (56)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative The Human Tumor Atlas Network (HTAN) aims to leverage the power of human genome sequencing and other state-of-the-art profiling technologies, to analyze spatial and temporal molecular changes in individual tumors. The HTAN Data Coordination Center (DCC) will ensure that all data generated by HTAN use the same data standards, that all data is hosted in one centralized location, and that all data is shared within HTAN and eventually with the wider scientific community. To maximize the research impact of the data generated, the DCC will also provide powerful analysis and visualization features, and these services and tools will enable researchers to make novel discoveries about the initiation and progression of cancer, as well as the development of resistance to cancer therapy.

PI_NAMEs: CERAMI, ETHAN  (contact);SCHULTZ, NIKOLAUS ;TAYLOR, ADAM JAMES;THORSSON, VESTEINN

PROGRAM_OFFICER_NAME: HANLON, SEAN E

PROJECT_TERMS: Address;anti-cancer research;Atlases;Automobile Driving;cancer therapy;Catalogs;cBioPortal;Cells;Clinical Data;Code;Communication;Communities;Community Outreach;computational pipelines;Data;data access;Data Commons;Data Coordinating Center;data curation;data modeling;data platform;data portal;Data Set;data standards;Data Storage and Retrieval;data submission;Development;Dimensions;Documentation;Education and Outreach;Ensure;Evaluation;Evolution;experience;Goals;Human;human genome sequencing;image visualization;improved;Individual;Information Technology;Infrastructure;Institution;Knowledge;Location;Manuals;Maps;Molecular;multimodal data;multiplexed imaging;Neoplasm Metastasis;novel;outreach;Plan B;Policies;Publications;Research;Research Personnel;Resistance development;Resources;Services;support network;Synapses;Technology;technology development;tool;Training;tumor;tumor progression;tumorigenesis;Validation;Vision;Visualization;Visualization software;Work;working group

PROJECT_TITLE: Human Tumor Atlas Network: Data Coordinating Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (M3)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PI_NAMEs: ZACHARIOU, VENETIA  (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Advisory Committees;Algorithms;Animal Model;Animals;Behavior;behavior test;Behavioral;Behavioral Assay;Biological Assay;Blood Chemical Analysis;Blood drug level result;Brain;Brain region;brain reward regions;brain tissue;Cell Physiology;cell type;Cells;Chromatin;chromatin modification;cocaine self-administration;Cognitive;cohort;Collaborations;Committee Members;Complex;Continuous Infusion;Corticosterone;Data;Dissection;Dominant-Negative Mutation;drug action;Drug Addiction;drug craving;drug relapse;Ensure;experimental study;Female;Fiber;gene function;Gene Transfer;Genes;Genetic;Genetic Transcription;genome-wide;Goals;Heroin;heroin use;Human;Image;in vivo;Individual;inhibitor;injection/infusion;Injections;interest;Knock-out;Link;male;mature animal;Measurement;Measures;Mediating;meetings;Microdissection;Modeling;Molecular;Motivation;Mus;mutant;Mutant Strains Mice;National Institute of Drug Abuse;neural circuit;Neuroglia;Neurons;neurophysiology;Neurosecretory Systems;novel;Opiate Addiction;Opioid;optogenetics;osmotic minipump;overexpression;Pharmaceutical Preparations;Photometry;Plasma;Procedures;Process;Program Research Project Grants;Proteins;Rattus;Relapse;Research Personnel;Resources;RNA;Rodent;Rodent Model;Role;Running;Self Administration;Services;small hairpin RNA;Specificity;statistics;Stimulant;stimulant dependence;Stress;Syndrome;Testing;tool;Viral Vector;Work

PROJECT_TITLE: Animal Models Core


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Substance Misuse

PI_NAMEs: SHEN, LI  (contact)

PROJECT_TERMS: addiction;advanced analytics;Advisory Committees;analytical tool;Animal Model;ATAC-seq;Autopsy;Bioinformatics;bioinformatics infrastructure;bioinformatics tool;Biological Assay;bisulfite sequencing;Brain;brain cell;Brain region;brain reward regions;brain tissue;cell type;Cells;ChIP-seq;Chromatin;chromatin modification;chromosome conformation capture;Collaborations;Communities;Complex;complex data;Data;Data Analytics;Data Set;data sharing;Development;DNA Methylation;Drug Addiction;Ensure;epigenome;epigenome editing;Experimental Designs;Faculty;Foundations;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;genome-wide;genome-wide analysis;Goals;Human;Human Genome;Human Resources;improved;in vivo;Individual;interest;Laboratories;large datasets;Lead;Leadership;Logistics;Measures;meetings;member;Methods;Modeling;Molecular;Neuroglia;Neurons;next generation sequencing;novel;Opiate Addiction;Program Research Project Grants;Protocols documentation;Regulation;Research;Research Personnel;Resource Sharing;Resources;reward circuitry;Rodent;rodent genome;Rotation;Running;sex;sharing platform;stimulant dependence;Substance Use Disorder;success;Technology;tool;transcriptome;transcriptome sequencing;whole genome;Work

PROJECT_TITLE: Gene and Chromatin Analysis Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

PHR: PROJECT NARRATIVE – PROJECT 1  Addiction remains one of the world’s greatest public health problems, yet its pathophysiology remains incompletely understood and available treatments for addictions to various drugs of abuse are inadequately effective for most people. The Project’s focus on transcriptional regulation is a critical part of this Program Project Grant’s efforts to contribute to a better understanding of the neurobiological basis of addiction, which we believe will facilitate the eventual development of definitive treatments and cures for substance use disorders.

PI_NAMEs: NESTLER, ERIC J. (contact)

PROJECT_TERMS: Acute;addiction;Animal Model;Architecture;Autopsy;Behavior Control;Behavioral;behavioral phenotyping;behavioral response;Big Data;Binding;Binding Sites;Bioinformatics;Biological Assay;bone;Brain;Brain region;cell type;Chromatin;chromatin immunoprecipitation;Chronic;Cocaine;Cocaine Dependence;cocaine exposure;cocaine self-administration;Cocaine use disorder;Complex;CREB1 gene;Data;Data Set;deep sequencing;desensitization;Development;Disease;DNA;drug action;Drug Addiction;drug of abuse;E2F transcription factors;E2F3 protein;Exposure to;Family;Functional disorder;Gene Expression;Genes;Genetic Transcription;Genome;genome-wide;Genomics;Goals;Human;Investigation;knock-down;Laboratories;Link;Literature;Maps;Medial;Mediating;Mediator;Modeling;Mus;Neurobiology;Neurons;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid abuse;overexpression;Persons;Phenotype;Play;Prefrontal Cortex;Program Research Project Grants;promoter;Protein Isoforms;Proteins;Public Health;Recording of previous events;Regulation;Reporting;response;RNA analysis;RNA Splicing;Rodent;Role;Self Administration;Signal Transduction;Stimulant;stimulant dependence;Substance Use Disorder;transcription factor;Transcriptional Regulation;transcriptome sequencing;Tretinoin;Validation;virtual;Work

PROJECT_TITLE: Novel Transcription Factors in Stimulant and Opiate Action


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PHR: PROJECT NARRATIVE – PROJECT 2  Addiction remains one of the world’s greatest public health problems, yet its pathophysiology remains incompletely understood and available treatments for addictions to various drugs of abuse are inadequately effective for most people. The Project’s focus on circular RNAs is a critical part of this Program Project Grant’s efforts to contribute to a better understanding of the neurobiological basis of addiction, which we believe will facilitate the eventual development of definitive treatments and cures for substance use disorders.

PI_NAMEs: KENNY, PAUL J. (contact)

PROJECT_TERMS: Abstinence;addiction;Autopsy;Aversive Stimulus;Awareness;Behavior;Behavioral;Biological Assay;Biological Process;Brain;Brain region;cell type;Cells;Chromatin;circular RNA;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;Cocaine Dependence;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;Collaborations;Consumption;Corpus striatum structure;CRISPR/Cas technology;Data;Development;Disease;Dopamine D1 Receptor;Dorsal;Dose;Drug Addiction;drug of abuse;Etiology;Functional disorder;Future;Genes;Genetic Transcription;Goals;Habits;Human;human subject;human tissue;In Situ Hybridization;in vivo;innovation;insight;Intake;Investigation;knock-down;Laboratories;Laboratory Animals;Mammalian Cell;Mediating;Methods;MicroRNAs;Modeling;Molecular;Motivation;mouse model;Mus;Nature;Neurobiology;Neuroglia;neuronal excitability;Neuronal Plasticity;Neurons;novel;Nucleus Accumbens;opioid abuse;Pattern;Persons;Pharmaceutical Preparations;Play;Population;Program Research Project Grants;Property;Proteins;Public Health;Regulation;Relapse;response;reward circuitry;RNA;RNA Interference;Role;Self Administration;Site;Slice;Substance Use Disorder;Synapses;Synaptic Transmission;Transcript;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Untranslated RNA;virtual;Whole-Cell Recordings;Work

PROJECT_TITLE: Role for Circular RNAs in Compulsive Cocaine Intake


NIH_SPENDING_CATS: Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PHR: PROJECT NARRATIVE – PROJECT 3  Addiction remains one of the world’s greatest public health problems, yet its pathophysiology remains incompletely understood and available treatments for addictions to various drugs of abuse are inadequately effective for most people. The Project’s focus on microglia is a critical part of this Program Project Grant’s efforts to contribute to a better understanding of the neurobiological basis of addiction, which we believe will facilitate the eventual development of definitive treatments and cures for substance use disorders.

PI_NAMEs: SCHAEFER, ANNE  (contact)

PROJECT_TERMS: Ablation;Acute;addiction;Address;Adult;Agonist;Apoptotic;Behavior;Behavior Control;Behavioral;behavioral response;Brain;Brain region;cell type;Cells;Chronic;Cocaine;cocaine exposure;cocaine self-administration;conditioned place preference;Corpus striatum structure;Data;Dendritic Spines;density;Development;Disease;Dopamine;Dopamine Agonists;Dopamine D1 Receptor;Dopamine Receptor;Dorsal;Drug Addiction;drug of abuse;Exhibits;experimental study;Feedback;Follow-Up Studies;Functional disorder;Future;Gene Expression;Gene Expression Profile;gene network;Genes;Genetic;Genetic Transcription;Human;innovation;Investigation;Knock-out;Lead;Mediating;Mediator;Microglia;Modeling;Molecular;Monitor;Morphology;Motor Activity;Mus;Mutant Strains Mice;Neurobiology;neuronal survival;Neurons;novel;Nucleus Accumbens;Opioid;Pathogenesis;Pathway interactions;Pattern;Persons;Pharmacologic Substance;Phenotype;Play;Production;Program Research Project Grants;Public Health;receptor expression;Receptor Signaling;Regulation;Relapse;response;Role;Scheme;selective expression;Self Administration;single cell analysis;Substance Use Disorder;Synapses;Testing;Therapeutic Intervention;transcriptome sequencing;transmission process

PROJECT_TITLE: Role of Microglia in Cocaine Actions


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

PHR: PROJECT NARRATIVE – PROJECT 4  Addiction remains one of the world’s greatest public health problems, yet its pathophysiology remains incompletely understood and available treatments for addictions to various drugs of abuse are inadequately effective for most people. The Project’s focus on gene enhancer regions is a critical part of this Program Project Grant’s efforts to contribute to a better understanding of the neurobiological basis of addiction, which we believe will facilitate the eventual development of definitive treatments and cures for substance use disorders.

PI_NAMEs: HURD, YASMIN L. (contact)

PROJECT_TERMS: Acetylation;Acquired Immunodeficiency Syndrome;addiction;Affect;Animal Model;ATAC-seq;automobile accident;Autopsy;Behavior;Behavioral;Binding;Bioinformatics;Brain;Brain region;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Buprenorphine;cancer therapy;Caring;Cell Nucleus;Cell Separation;cell type;Cells;Cessation of life;ChIP-seq;Chromatin;chromatin modification;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;clinical development;Clinical Trials;Communities;Corpus striatum structure;Data;Data Set;Development;Disease;Dorsal;Drug Addiction;drug addiction therapy;drug of abuse;Drug usage;Enhancers;Epidemic;Epigenetic Process;Family;fentanyl use;Functional disorder;Gene Abnormality;Gene Expression;Gene Expression Regulation;gene network;Gene Transfer;Genes;genetic regulatory protein;Genetic Transcription;Genome;genome-wide;Glutamates;Growth;Guns;Healthcare Systems;Height;Heroin;heroin abuser;Heroin Dependence;heroin use;Heroin Users;Histone Acetylation;Histone H3;histone modification;Histones;Human;Immunity;Inflammation;insight;Intervention;knock-down;Knowledge;Link;Maps;Mediating;Medical;member;Methadone;Modeling;Molecular;Morphology;Neurobiology;Neuroglia;Neurons;novel;novel therapeutics;Nucleus Accumbens;Opiate Addiction;Opioid;Opioid Analgesics;opioid epidemic;opioid overdose;Opioid replacement therapy;opioid use;opioid use disorder;Overdose;overexpression;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Population;prescription opioid;Program Research Project Grants;Protein Family;Proteins;Public Health;Rattus;Regulation;Regulatory Element;Rodent;Role;Safety;Sampling;screening;Self Administration;Services;small molecule;social stigma;Substance Use Disorder;Switch Genes;Synaptic plasticity;targeted agent;Testing;Therapeutic;Tissues;transcription factor;transcriptome sequencing;translational potential;Viral;Work

PROJECT_TITLE: Regulation of Gene Enhancers in Human Heroin Use


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Hematology;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Cancer-related thrombosis is the second leading cause of death for cancer patients and glioblastoma (GBM), the most common primary malignant brain tumor, is associated with approximately a 30% risk of venous thromboembolism, deep vein thrombosis, or pulmonary embolisms. While this remains a major clinical issue, the role that the hyper-thrombotic state plays on contributing to the immunosuppressive tumor microenvironment in GBM has not been explored. This study aims to understand how platelet hyperactivity and the thrombin-PAR4 signaling axis contributes to the immunosuppressive tumor microenvironment in a sex-dependent manner.

PI_NAMEs: SLOAN, ANTHONY ROBERT (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Advisory Committees;Area;biological sex;Biology;Blood Platelets;Bone Marrow;Cancer Patient;Cause of Death;Cell Communication;Cell Physiology;Cells;Chimera organism;Clinic;Clinical;Confocal Microscopy;Data;Deep Vein Thrombosis;Disease Progression;Event;Exhibits;experimental study;F2R gene;Female;Flow Cytometry;Foundations;Functional disorder;Glioblastoma;Goals;Histology;Human;Hyperactivity;Immune;Immunology;Immunosuppression;inhibitor;Laboratories;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;member;men;Mentors;Modeling;mouse model;Mus;neoplastic cell;neuro-oncology;Neurobiology;Outcome;Patients;PAWR gene;pharmacologic;Platelet Activation;Platelet Count measurement;Play;Population;Postdoctoral Fellow;pre-clinical assessment;Pre-Clinical Model;prevent;Prognosis;Pulmonary Embolism;receptor;receptor expression;Receptor Signaling;Research;Risk;Role;sex;Sex Bias;Sex Differences;Signal Transduction;statistics;T cell infiltration;T-Cell Depletion;T-Lymphocyte;Testing;Therapeutic;therapeutic target;therapy development;Thrombin;Thrombosis;tumor;tumor growth;tumor microenvironment;tumor-immune system interactions;venous thromboembolism;Wild Type Mouse;Work

PROJECT_TITLE: A Hyper-Thrombotic State and Immunosuppression in GBM

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-C (20)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Nutrition;Physical Activity;Precision Medicine;Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Metabolites are often endpoints and markers of human physiology, and a collection of metabolites can potentially define homeostatic states of human health. We bring together metabolomics measurements on human subjects from three defined perturbations, namely, exercise, diet, and environmental exposome, from the three national projects, MoTrPAC, NPH, and HHEAR, respectively, in defining the metabotypes (homeostatic states) through exploration of the metabolomic hyperspace. We hypothesize that, from large-scale metabolomic measurements on humans, we can define metabotypes that define the homeostatic state of a collection of metabotypes and define how perturbations from this state can be addressed through targeted interventions and provide the metabotype calculator as the most valuable product from this project.

PI_NAMEs: SUBRAMANIAM, SHANKAR  (contact)

PROGRAM_OFFICER_NAME: KANO, KRISTIN KATHLEEN

PROJECT_TERMS: Address;Affect;analytical tool;Biological;Classification;cohort;Collection;Communities;Data;Data Analytics;data ecosystem;data harmonization;data repository;Data Set;Development;Diet;diet and exercise;Disease;Documentation;Environment;Environmental Exposure;epigenomics;Exercise;Foundations;Funding;Genes;Genetic;Genome;genome sequencing;genomic variation;Genotype;Goals;graphical user interface;Health;Human;human subject;Individual;individual variation;Infrastructure;innovation;Intervention;learning strategy;Life Style;Machine Learning;Maps;Measurement;Measures;Metabolic;metabolic phenotype;Metabolism;metabolome;metabolomics;Metadata;Methods;Modality;Modeling;Molecular;Monitor;National Institute of Environmental Health Sciences;Nature;novel;Pathologic;Physical activity;Physicians;Physiological;Physiology;Precision Health;precision nutrition;Principal Investigator;Recommendation;Research Personnel;Resources;Self Assessment;Site;Solid;success;System;Technology;Time;Tissues;tool;Transducers;United States National Institutes of Health;Variant;vector;web site

PROJECT_TITLE: "Defining the Human Metabotype" [Human metabolic status defined through genetic, diet,environmental exposure and exercise perturbations]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The Integrated Stress Response (ISR) regulates a wide range of host cell functions in response to environmental and infected-induced perturbations through transcriptional and translational control. We find that the bacterium Salmonella enterica serovar Typhi induces the macrophage ISR during infection and macrophage lacking key ISR components are impaired in their innate immune functions. This study will define how the ISR governs macrophage function, polarization, and metabolism in response to S. Typhi infection and will reveal novel targets for future targeted therapeutic development against this global pathogen.

PI_NAMEs: POWERS, ZACHARY MICHAEL (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Apoptosis;Bacteria;biological adaptation to stress;Biological Assay;Biological Models;Biology;Bone Marrow;Cell Culture Techniques;Cell Physiology;Cell Reprogramming;cell type;Cells;Cellular Stress;Cessation of life;Clinical;cytokine;Data;Disease;drug development;Drug Targeting;Environment;Evolution;Functional disorder;Future;Genetic Transcription;global health;Goals;Homeostasis;Human;human pathogen;Immune;immune function;Immune response;Impairment;in vivo;Infection;Infection Control;Inflammatory;innate immune function;Innate Immune Response;Integration Host Factors;Invaded;Knowledge;Macrophage;Macrophage Activation;Mediating;Metabolic;Metabolism;metabolomics;microbial;Modeling;mouse model;Mus;Natural Immunity;novel;Nutrient;Outcome;pathogen;pathogenic bacteria;Pathologic;Pathway interactions;Phosphotransferases;repaired;Research;Resolution;respiratory;response;Ribosomes;Role;Salmonella enterica;Salmonella typhi;Salmonella typhimurium;sensor;Shapes;Signal Pathway;Signal Transduction;stem;Stimulus;Stress;stressor;targeted treatment;Techniques;Testing;therapeutic development;Therapeutic Intervention;transcription factor;Transcriptional Regulation;Translational Regulation;Typhoid Fever;Virulence Factors

PROJECT_TITLE: Integrated Stress Response-mediated macrophage innate immunity during maladapted Salmonella enterica infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Data Science;Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: WASHINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: The proposed project will establish a structured representation of biomarkers of clinical interest, with links to related knowledge models (e.g. genes, proteins, glycans, metabolites, disease, phenotype, cell, tissue, and EHR codes). Semantic modeling of biomarkers will empower novel comparisons across related medical domains, Common Fund datasets, and make biomarker information findable, accessible, interoperable, and reusable (FAIR).

PI_NAMEs: MAZUMDER, RAJA  (contact)

PROGRAM_OFFICER_NAME: KINSINGER, CHRISTOPHER

PROJECT_TERMS: biocomputing;Biological Assay;Biological Markers;Biological Process;biomarker driven;cancer biomarkers;Cancer Research Network;candidate marker;Categories;Cells;Classification;Clinical;clinically relevant;Code;Collaborations;Collection;Communities;Data;data access;Data Analyses;Data Coordinating Center;data dictionary;data ecosystem;Data Element;data harmonization;Data Linkages;data modeling;data resource;Data Science;Data Set;Data Sources;Development;Disease;disease classification;Early Detection Research Network;Education and Outreach;Electronic Health Record;Emerging Technologies;empowerment;Ensure;FAIR principles;Funding;Genes;Genome;graph learning;Health;health data;health record;Human;improved;indexing;innovation;interest;interoperability;Intervention;Knowledge;knowledge graph;Language;Licensing;Link;Logical Observation Identifiers Names and Codes;Machine Learning;Malignant Neoplasms;Maps;Medical;metabolomics;Metadata;metadata standards;Methodology;Methods;Modeling;Molecular;molecular marker;novel;Ontology;Outcome;outreach;Pathway interactions;permissiveness;Pharmaceutical Preparations;Phenotype;Polysaccharides;predictive marker;predictive modeling;Property;Proteins;Research;Resources;Semantics;Series;Source;Structure;System;Technology;Testing;Tissues;tool;Training;translational pipeline;Update;usability;Visualization;Visualization software

PROJECT_TITLE: Enhancing and making Biomarker Knowledge FAIR using contextual CFDE data


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Since cochlear synaptopathy is a common cochlear pathology in aging humans, it is crucial to understand what effects this condition has on the auditory system and how to detect it. The current study in an animal model will determine how auditory-nerve response properties are affected by synaptopathy and to develop tools for detecting this cochlear pathology. These results can help guide strategies to treat cochlear synaptopathy and ultimately improve quality of life in people with this common health problem.

PI_NAMEs: GONZALES, LESLIE  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustic Nerve;Affect;Age;Aging;analog;Animal Model;Animals;Auditory;Auditory Brainstem Responses;auditory discrimination;Auditory system;Autopsy;Behavioral;behavioral impairment;behavioral study;Birds;Cavia;Cell Physiology;Characteristics;Cochlea;cochlear synaptopathy;Complex;Comprehension;Control Animal;Data;Detection;Diagnosis;diagnostic tool;discrimination task;Ear;Evoked Potentials;excitotoxicity;experimental group;experimental study;Fiber;Frequencies;Gerbils;Glutamates;Hair Cells;Health;Hearing;Hearing Tests;hidden hearing loss;Histologic;histological specimens;histological studies;Human;Impairment;improved;Infusion procedures;Injury;Inner Hair Cells;interest;Investigation;Kainic Acid;Knowledge;Laboratory Animals;Mammals;Masks;Measures;Melopsittacus;Methods;Modeling;Mus;Nerve Fibers;neural;Noise;normal hearing;Parakeets;Pathology;Pattern;Perception;Performance;Peripheral;Persons;Physiological;Physiology;Prevalence;Process;Property;Public Health;Quality of life;Records Controls;Research;response;ribbon synapse;Scalp structure;Shapes;sound;Speech;statistics;Stimulus;Structure;Study models;Synapses;Testing;tool

PROJECT_TITLE: The Effect of Cochlear Synaptopathy on Auditory Nerve Responses in the Budgerigar

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (13)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Congenital Structural Anomalies;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: LARCHMONT

ORG_NAME: BARTH SYNDROME FOUNDATION

PHR: Narrative Barth syndrome (BTHS) is an ultra-rare, life-threatening genetic disease that affects ~320 individuals globally, making development of treatments challenging due to limited commercial interest and resources. The mission of the Barth Syndrome Foundation (BSF)–a patient advocacy group for those affected by BTHS–is to save lives through education, advances in treatments, and finding a cure for the disease. The Science and Medical Conference on Barth Syndrome will stimulate new clinical and scientific progress, convene affected families with scientists and clinicians and bring discoveries from the benchtop to treatments.

PI_NAMEs: GREENBERG, MIRIAM L (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: 3-Methylglutaconic aciduria type 2;Acceleration;Affect;Cardiomyopathies;Clinical;clinical trial readiness;Clinical Trials;clinically relevant;Collaborations;Communities;Data;digital;Disease;drug discovery;Education;Evaluation;Face;Family;Fatigue;FDA approved;feeding;forging;Fostering;Foundations;Future;gene therapy;Genetic Diseases;Goals;Growth;Health Personnel;Heart Transplantation;Individual;Institution;interest;Life;male;Medical;meetings;Mission;mouse model;Myopathy;Natural History;Neutropenia;novel;open label;pandemic disease;patient advocacy group;Patients;Persons;Pharmaceutical Preparations;Physicians;pre-clinical;Prevalence;programs;Rare Diseases;Reporting;Research;Research Personnel;Resource Sharing;Resources;Science;Scientific Advances and Accomplishments;Scientist;skeletal;supportive environment;Surveys;symposium;Therapeutic;therapeutic development;therapy development;tool;virtual

PROJECT_TITLE: 2024 Scientific and Medical Conference on Barth Syndrome: Benchtop to Treatments

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M4)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed research project is fundamental for understanding the biophysical properties of Piezo channels which are involved in sensing touch, lung inflation, bladder stretch, and blood pressure and is therefore relevant to public health. Its long-term positive impact may be in developing new strategies for treating diseases such as itch, inflammatory pain, and chronic pain.

PI_NAMEs: SINDONI, MICHAEL JAMES (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Affect;Algorithms;Alternative Splicing;Arthrogryposis;Biophysical Process;biophysical properties;Bladder;Blood Pressure;blood pressure regulation;cell type;Cells;chronic pain;Closure by clamp;Custom;Data;Detection;Disease;Distal;Electrophysiology (science);Engineering;Exhibits;experimental study;gain of function;Gastrointestinal Transit;Goals;Gordon syndrome;Human;human disease;Image Analysis;Individual;inflammatory pain;innovation;insight;Investigation;Ion Channel Gating;Kinetics;Light;Logic;loss of function mutation;Lung;Measures;mechanical stimulus;mechanotransduction;Membrane;Molecular;Mus;Nomarski Interference Contrast Microscopy;Pattern;Physiological;Physiology;Piezo 2 ion channel;Piezo ion channels;Play;pressure;Process;programs;Property;Proprioception;Proteins;Protocols documentation;Pruritus;Public Health;Rationalization;Recovery;Research;Research Project Grants;response;RNA Splicing;Role;sensor;Stimulus;Stretching;Structure;Testing;Tissue-Specific Splicing;Tissues;tool;Touch sensation;transduction efficiency;Urination;Variant;Work

PROJECT_TITLE: Biophysical characterization of the human force-gated ion channel Piezo2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04B-S (20)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative: Although immune checkpoint blockade (ICB) therapeutics have proved the possible efficacy of immunotherapies in non-small cell lung cancer (NSCLC), most patients do not respond to these treatments durably. This proposal aims to use spatial functional genomics in coordination with highly-multiplexed imaging to illuminate the specific roles of SOCS1 and all other interferon gamma (IFNy) stimulated genes (ISGs) in generating an immunosuppressive environment within the tumor microenvironment (TME) and regulating resistance and response to ICB.

PI_NAMEs: TEPPER, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acute;advanced disease;anti-PD-1;anti-PD-L1 therapy;Architecture;Bar Codes;Biological;Biology;cancer cell;Cancer Etiology;cancer immunotherapy;Cancer Patient;career;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chemotherapy-Oncologic Procedure;Chronic;clinical remission;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complex;cytokine;Cytokine Gene;Data;Disease;DNA Sequence Alteration;Enabling Factors;Environment;Equilibrium;Exclusion;experimental study;functional genomics;Genes;Genetic;genetic signature;genomic platform;Goals;Growth;Histopathology;Human;Immune;immune checkpoint blockade;immune clearance;Immune Evasion;Immune system;Immunotherapy;improved;Infiltration;Interferon Type II;Interferons;Knock-out;knockout gene;Lung Neoplasms;Lymphocytic Infiltrate;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mediating;Methods;Molecular;mortality;mouse model;multiplexed imaging;neoplastic cell;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;Outcome;Outcome Study;Pathologic;Pathway interactions;patient subsets;Patients;PD-1/PD-L1;PD-L1 blockade;Phenotype;Play;preservation;programmed cell death ligand 1;programs;Progression-Free Survivals;Proteins;recruit;Reporting;Resistance;Resistance development;resistance mechanism;Resolution;response;Role;Sampling;Signal Pathway;Signal Transduction;Specimen;success;Survival Rate;T cell infiltration;Techniques;Technology;Testing;Therapeutic;therapeutic target;Tissues;transcriptome sequencing;transcriptomics;tumor;Tumor Biology;Tumor Burden;Tumor Immunity;tumor microenvironment;United States;Up-Regulation

PROJECT_TITLE: Deconvoluting the contributions of the IFNy pathway components to lung TME and tumor immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (22)]


ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE This project is relevant to the mission of the NIH because Cryptococcus neoformans is an important human pathogen, and this project aims to understand the molecular processes involved in fungal disease development. Characterizing the function of host inositol in Cryptococcus pathogenesis will advance our understanding of disease mechanisms in life-threatening cryptococcal meningitis and will guide efforts to develop new disease prevention and control strategies.

PI_NAMEs: XUE, CHAOYANG  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Animal Model;anti-fungal agents;Binding;Binding Sites;Biological Assay;Biology;biophysical techniques;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier penetration;Brain;capsule;Catabolism;Cell surface;Cells;Central Nervous System;Central Nervous System Infections;ChIP-seq;Complex;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Data;Development;Disease;disorder control;disorder prevention;Electrophoretic Mobility Shift Assay;Environment;extracellular;Funding;fungus;Future;Genes;Genetic;Genetic Screening;Genetic Transcription;Genus Hippocampus;glucuronoxylomannan;Goals;Group Structure;Growth;Human;human pathogen;Hyaluronic Acid;Hydrophobic Surfaces;Immune response;In Vitro;in vivo;Infection;inhibitor;Inositol;insight;Knowledge acquisition;Life;light scattering;Measurement;Mediating;Membrane;Meningitis;Meningoencephalitis;Metabolic;Metabolism;metabolomics;migration;Mission;Modeling;Modification;Molecular;Molecular Biology;mouse model;Mus;Mutagenesis;mutant;Mycoses;myoinositol;Nutrient;Oryctolagus cuniculus;pathogen;Pathogenesis;Pathway interactions;Play;Polysaccharides;Process;Production;promoter;Proteins;receptor;Regulation;Research;Role;sensor;Shapes;Structure;sugar;System;Testing;Therapeutic;therapeutic target;transcription factor;United States National Institutes of Health;uptake;Virulence;Virulence Factors;yeast two hybrid system

PROJECT_TITLE: The role of inositol in Cryptococcus biology and pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-D (02)]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: NMDA receptors are glutamate-gated excitatory ion channels with essential roles in the central nervous system, whose activation mechanism remains incompletely understood, thus preventing the development of rational approaches for the treatment of a variety of neuropsychiatric disorders. The parent project uses an integrated approach that integrates computational modeling of structural changes that represent the receptor activation reaction and comprehensive testing of the computationally-generated hypotheses with electrophysiological measurements. In this supplement we propose do delineate electrophysiological properties of a truncated NMDA receptor protein that we used successfully to model the gating reaction, but for which functional information is unavailable.

PI_NAMEs: POPESCU, GABRIELA K (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;Agonist;antagonist;Architecture;Binding;C-terminal;Central Nervous System;Characteristics;clinically relevant;Computer Models;Computer Simulation;computerized tools;Coupled;Cryoelectron Microscopy;Data;desensitization;Development;Disease;disease-causing mutation;Electrophysiology (science);extracellular;Family;Functional disorder;Glutamate Receptor;Glutamates;Goals;Grain;Hot Spot;Image;Intervention;Investigation;Ion Channel;Ions;kinetic model;Kinetics;Knowledge;Length;Link;Maps;Measurement;Mediating;member;Missense Mutation;Modeling;Molecular Conformation;molecular dynamics;molecular modeling;Movement;mutant;Mutation;N-Methyl-D-Aspartate Receptors;N-terminal;neurophysiology;neuropsychiatric disorder;Neurotransmitter Receptor;Output;parent grant;parent project;Pathology;Patients;Permeability;pharmacologic;prevent;Property;Protein Isoforms;protein structure;Proteins;Reaction;receptor;Receptor Activation;Receptor Gene;Records;Rest;Roentgen Rays;Role;Series;Shapes;simulation;Site;Specificity;Structural Models;Structure;Synaptic plasticity;Synaptic Transmission;Testing;Thermodynamics;Transmembrane Domain

PROJECT_TITLE: Diversity Supplement for Faye Raymond


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Women's Health Research

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Transgender women have disproportionally high rates of sexually transmitted infections including human immunodeficiency virus, which is maintained after adjusting for high-risk behaviours. Little is known about the neovaginal microenvironment following gender affirming vaginoplasty, which could have important implications for mucosal health in transgender women. In this project we will profile the neovaginal microbiome and its’ association with inflammation, bacterial functions, and gynecological symptoms.

PI_NAMEs: FARR ZUEND, CHRISTINA  (contact);POPE, RACHEL JEAN

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: 16S ribosomal RNA sequencing;Amines;Behavior Therapy;Biological Factors;Birth;Blood specimen;Caring;chemokine;cis-female;Clinical;clinical examination;cohort;cytokine;dysbiosis;Enrollment;Epithelium;evidence base;evidence based guidelines;follow-up;gender affirmation;gender affirming medical care;Gender Confirmation Surgery;Gender Identity;Genitalia;Guidelines;gut microbiome;Gynecologic;Health;high risk behavior;HIV;hormone therapy;Hospitals;Hygiene;IL8 gene;immune activation;Inflammation;Inflammatory;Interleukin-6;Invaded;Knowledge;Lactobacillus;Link;Long-Term Care;Maintenance;Mass Spectrum Analysis;metabolomics;Metagenomics;metaproteomics;microbial;microbial colonization;microbiome;Mobiluncus;Mucous Membrane;neovagina;Odors;Operative Surgical Procedures;Oral;Outcome;Pain;Patients;penile microbiome;penis;Peptostreptococcus;Peritoneal;Persons;Play;Population;Porphyromonas;Postoperative Care;Postoperative Period;Prevalence;Prevotella;Procedures;Questionnaires;Recommendation;Rectum;Risk;Role;Sampling;Schedule;sex assigned;Sex Behavior;Sex Characteristics;Sexually Transmitted Diseases;Skin;skin microbiome;Source;Specimen;Swab;Symptoms;Testing;Time;Tissues;transgender;transgender women;Vagina;vaginal microbiome;vaginoplasty;Visit;Volatile Fatty Acids;Vulva

PROJECT_TITLE: Defining the neovaginal microbiome after gender affirming vaginoplasty

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LAWRENCE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: NARRATIVE The severity of bacterial infections is often influenced by the complexity of the infecting community and interactions among members of the community. Many of these interactions are regulated by quorum sensing, a type of cell-cell signaling. The primary objective of this proposal is to define how quorum sensing alters the dynamics of populations in multispecies communities and patient infections, with the long-term goal of informing efforts to target quorum sensing to control infection populations.

PI_NAMEs: CHANDLER, JOSEPHINE R (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Animals;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Bacteria;bacterial community;Bacterial Infections;Behavior;cell type;Clinical;Communities;Complex;Disease;Ecology;effective therapy;Environment;Evolution;Genetic;Genomics;Goals;Individual;Infection;Infection Control;intercellular communication;Laboratories;laboratory development;member;microbial community;Modeling;Molecular Biology;new technology;novel;opportunistic pathogen;pathogen;Pathogenesis;Patients;Phenotype;Plants;Population;Population Density;Population Dynamics;Pseudomonas aeruginosa;quorum sensing;Regulation;Resistance;Role;Severities;Shapes;Social Behavior;Social Interaction;Soil;System;Therapeutic;treatment strategy;Virulence

PROJECT_TITLE: Quorum sensing evolution and function in mixed bacterial communities


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

PHR: PROJECT NARRATIVE Neurodevelopmental disorders encompass a range of intellectual, social, and behavioral deficits, and are increasingly prevalent in the child population. Functional insulin/insulin-like growth factor (IGF) signaling is required for proper brain growth and function and, thus, is closely regulated by IGF binding proteins. Since dysregulation of IGF signaling is strongly linked to developmental diseases, this project seeks to uncover regulatory mechanisms of IGF binding proteins in central brain circuit formation and function while exploring potential avenues for therapeutic intervention in neurodevelopmental disorders.

PI_NAMEs: RYDBOM, JERRIK  (contact)

PROJECT_TERMS: Address;Adult;Aging;Animals;Autonomic nervous system;Axon;Behavior;Behavioral;Binding;Biological;Biological Process;Brain;Brain region;career;Cells;Central Nervous System;Child;Circadian Rhythms;Clustered Regularly Interspaced Short Palindromic Repeats;Cysteine;Data;Defect;Development;developmental disease;Drosophila genome;Drosophila genus;Drosophila inturned protein;Electrophysiology (science);Endocrine;Event;experimental study;Feedback;fly;Functional impairment;gain of function;Gene Chips;Genes;Genetic;Genome;Genome engineering;Goals;Growth;Homeostasis;Homologous Gene;Hunger;Hypothalamic structure;immunocytochemistry;innovation;insight;Insulin;insulin secretion;insulin signaling;Insulin-Like Growth-Factor-Binding Proteins;insulin-like peptide;Integral Membrane Protein;Invertebrates;Label;Learning;Link;loss of function;Maps;Memory;Metabolic;Metabolism;Modeling;Molecular;Molecular Target;Morphogenesis;Morphology;Motor Neurons;Mushroom Bodies;mutant;Nervous System Disorder;neural circuit;Neurodevelopmental Disorder;Neuromuscular Junction;Neurons;Neuropeptides;new therapeutic target;novel;Output;Pathogenesis;Pathway interactions;Peripheral;Phenotype;Physiological Processes;Population;Positioning Attribute;Protein Binding Domain;Regulation;release factor;Reproduction;Role;Satiation;Scheme;Signal Transduction;skills;Sleep;sleep behavior;sleep regulation;social;Somatomedins;spatiotemporal;Specificity;Stress;synaptogenesis;System;Techniques;Testing;Therapeutic Intervention;tool;training opportunity;Transforming Growth Factor beta;Wakefulness;Work

PROJECT_TITLE: Defining the function of a novel insulin-like growth factor binding protein in CNS development and function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This proposal will expand the infrastructure of the Community-Academic Aging Research Network (CAARN) in a new direction to promote the formation of innovative transdisciplinary teams including engineers and computer scientists, clinicians, healthcare providers, social scientists, and historically underrepresented older adults to facilitate the development, testing and dissemination of new or refined assistive technology to improve the health and function of older adults and reduce disparities.

PI_NAMEs: EDWARDS, DOROTHY FARRAR;JIANG, HONGRUI ;KING, BARBARA ;MAHONEY, JANE E (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Academia;Address;Adoption;age related;Aging;aging in place;Collaborations;Communication;Communities;community collaboration;community partners;computer science;computer scientist;County;design;Development;Discipline;disparity reduction;Educational Background;Educational Status;Engineering;Ensure;Environment;Equity;ethnic minority population;Exclusion;Extramural Activities;Feedback;Financial cost;Fostering;Funding;Goals;Grant;Health;health disparity;health equity;Health Personnel;Health Sciences;Hearing;improved;Individual;Infrastructure;innovation;instrumental activity of daily living;interdisciplinary collaboration;Interdisciplinary Study;Knowledge;low health literacy;low socioeconomic status;multidisciplinary;multiple chronic conditions;Network Infrastructure;older adult;Older Population;Phase;Population;Population Heterogeneity;Positioning Attribute;Privacy;Process;prototype;racial diversity;racial minority population;Research;Research Infrastructure;Research Personnel;research study;rural area;Safety;Scientist;Self-Help Devices;skills;social;Social Sciences;social stigma;Technology;technology development;technology intervention;Testing;therapy design;Thinking;Tribes;Underrepresented Populations;Underserved Population;Universities;Wisconsin

PROJECT_TITLE: Enhancing the Community-Academic Aging Research Network to Support Assistive Technology (AT) Research for Older Adults by Designing for Dissemination and Health Equity

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (M3)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homicide and Legal Interventions;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: Nashville

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE  The proposed project aims to identify patterns of nonfatal firearm-related intimate partner violence (IPV) involvement as well as examine the demographic characteristics and modifiable risk and protective factors that characterize subgroups of individuals who have experienced or perpetrated firearm-related IPV. The aims will be addressed through secondary analysis of three data sets: (1) middle and (2) high school youth, and (3) a nationally representative sample of adults. The results will broaden our understanding of how firearm-related IPV behaviors fit within the context of IPV across development, identify subgroups of individuals at the highest risk of firearm-related IPV involvement, and examine the modifiable risk and protective factors associated with patterns of firearm-related IPV involvement to prevent firearm-related injury and death among young people.

PI_NAMEs: STEVENS, LAURA TAYLOR (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;adverse childhood events;Age;age difference;age group;Behavior;Black race;black women;career;Cause of Death;Cessation of life;Characteristics;Child;Communities;community based participatory research;community violence;Competence;Data;Data Analyses;Data Set;Dedications;Development;emotion regulation;Ethnic Origin;Exclusion;experience;Exposure to;Family;Female Adolescents;firearm access;Firearms;Funding;Gender;girls;Goals;Grant;Gun injury;Guns;health disparity;High Prevalence;high risk;high school;Homicide;Individual;Injury;injury prevention;intimate partner violence;junior high school;Knowledge;life span;Manuscripts;Measures;men;Methods;Modeling;modifiable risk;mortality;National Institute of Child Health and Human Development;Outcome;Pattern;Persons;Policies;prevent;Prevention;Prevention strategy;protective factors;psychologic;Public Health;Race;racial population;Recording of previous events;Reduce health disparities;Research;research data dissemination;Research Priority;Research Project Grants;Risk;Risk Factors;Sampling;Science;Scientist;secondary analysis;skills;social;Social support;Statistical Methods;Subgroup;Testing;Theoretical model;Time;Training;Traumatic injury;Violence;violence perpetration;violence victimization;Violent injury;White Women;Woman;Work;Writing;young adult;young woman;Youth

PROJECT_TITLE: Patterns of firearm-related intimate partner violence across developmental stages: Risk and protective factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Rare Diseases;Regenerative Medicine

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The present grant will identify the mechanisms by which mitochondria dependent TCA cycle metabolism and NAD+ regeneration control tumor initiation and progression.

PI_NAMEs: CHANDEL, NAVDEEP S (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Address;Adenocarcinoma Cell;Adult;aerobic glycolysis;airway epithelium;Allografting;alveolar epithelium;Antioxidants;Aspartate;Automobile Driving;Back;cancer cell;Cancer cell line;Cell Differentiation process;Cell Line;Cell Physiology;Cell Survival;Cells;Citric Acid Cycle;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complex;CRISPR screen;Cytoplasm;Cytosol;Data;Development;Electron Transport;Engineering;Enzymes;Epithelial Cells;Essential Genes;experimental study;Fumarates;functional genomics;Generations;Genes;Glutathione;Glycolysis;Grant;Growth;Heme;Homeostasis;Hypoxia;Immunocompetent;Impairment;In Vitro;in vivo;Investigation;Knock-out;KRAS oncogenesis;Lactobacillus brevis;Libraries;Link;Lipids;LoxP-flanked allele;Lung;Lung Adenocarcinoma;Lung Neoplasms;macromolecule;Maintenance;Malate Dehydrogenase;Malate-Aspartate Shuttle Pathway;Malates;Malignant neoplasm of lung;Malignant Neoplasms;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;mitochondrial metabolism;Mouse Cell Line;mouse model;Mus;NADH;NADH oxidase;Natural regeneration;Nature;Neoplasm Metastasis;Normal Cell;novel;nucleotide metabolism;Nucleotides;Nutrient availability;Oncogenes;Oxaloacetates;Play;Primary Neoplasm;Process;Production;Proliferating;Publishing;Pyruvate Carboxylase;Research;Role;Series;Signal Pathway;Succinates;Testing;TP53 gene;tumor;Tumor Expansion;tumor growth;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;Work

PROJECT_TITLE: Mitochondrial Metabolism and Cancer

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


NIH_SPENDING_CATS: Clinical Research;Lung;Machine Learning and Artificial Intelligence;Organ Transplantation;Prevention;Transplantation

PHR: PROJECT NARRATIVE Lung transplant is associated with high morbidity and mortality with complications such as acute cellular rejection (ACR) ultimately resulting in chronic lung allograft dysfunction (CLAD). The proposed experiments will reveal much-needed early indicators of CLAD where there are none and serial sampling will provide stronger evidence for the causality of biomarkers. Ultimately, elucidating early signs of ACR and CLAD for timelier intervention and revealing therapeutic targets will reduce lung transplant failure.

PI_NAMEs: LUO, LUCY  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute;airway epithelium;Alveolar;alveolar epithelium;Alveolar Macrophages;antagonist;Apoptosis;autocrine;Biological;Biological Markers;Biopsy;Cells;Chronic;Clinical;clinical biomarkers;Clinical Data;clinical diagnosis;cytokine;Data;design;Development;Diagnosis;differential expression;Disease;early detection biomarkers;Early identification;epithelial repair;Epithelium;Etiology;experimental study;Failure;Fibroblasts;Fibrosis;Flow Cytometry;Functional disorder;Gene Expression;Genes;Goals;hazard;Human;Immunology;improved;improved outcome;Injury;insight;Interruption;Intervention;Ligands;Link;Liquid substance;longitudinal analysis;Lung;lung allograft;Lung Diseases;Lung Transplantation;Machine Learning;machine learning algorithm;machine learning model;machine translation;Macrophage Activation;Macrophage Colony-Stimulating Factor;Macrophage Colony-Stimulating Factor Receptor;Maintenance;Measurement;Mentors;Modeling;Molecular;molecular marker;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Myofibroblast;novel;Outcome;paracrine;Paracrine Communication;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Physicians;Population;Pre-Clinical Model;prevent;Preventive measure;Proliferating;Pulmonary Fibrosis;Pulmonary Function Test/Forced Expiratory Volume 1;receptor;recruit;Regulatory T-Lymphocyte;repaired;Research;Resolution;Resources;response;Risk Factors;Sampling;Scientist;Series;Signal Transduction;single cell genomics;Single Nucleotide Polymorphism;skills;Source;standard of care;targeted treatment;Testing;therapeutic target;Time;Tissues;Training;transcriptomics;Translating;translational immunology;Translational Research;Transplant Recipients;Transplantation;Transplanted Lung Complication;ventilator-associated pneumonia;Visit;Work

PROJECT_TITLE: Loss of resident donor-derived Tregs and the emergence of monocyte-derived alveolar macrophages leads to acute rejection and chronic dysfunction in lung transplant recipients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the digestive tract and though there are treatments for IBD, there are currently no cures. This proposal aims to define how certain cells of the intestinal epithelium help repair tissue injury using mouse and organoid models. Findings from this work may identify novel pathways to new therapies for healing the intestinal epithelium in patients with IBD.

PI_NAMEs: KATADA, KAY  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Ablation;Address;adult stem cell;Affect;American;Autophagocytosis;base;Cell Death;cell dedifferentiation;Cell Differentiation process;cell injury;Cell Proliferation;cell type;Cells;Chronic;Collagen;Cre driver;Data;Defect;defined contribution;differential expression;Disease;Dyes;Epithelial Cells;epithelial repair;Epithelium;epithelium regeneration;Exhibits;fetal;Flow Cytometry;Gastrointestinal tract structure;Gene Activation;Gene Expression;Genes;Genetic Transcription;Goals;healing;Homeostasis;Immune response;Impairment;in vivo;in vivo regeneration;Inflammation;Inflammatory Bowel Diseases;inhibitor;Injury;intercalation;intestinal barrier;intestinal epithelium;Intestines;irradiation;Kinetics;Knockout Mice;LGR5 gene;Literature;Location;Measures;Mediating;Membrane Proteins;Modeling;Molecular;Mus;Natural regeneration;novel;novel therapeutics;Organoids;Paneth Cells;Pathogenesis;Pathway interactions;Patients;Play;Positioning Attribute;Process;programs;protein activation;protein biomarkers;Proteins;Radiation Injuries;Recovery;relapse risk;repaired;Role;Secretory Cell;self-renewal;Signal Pathway;Signaling Protein;Sorting;Stains;stem;stem cell exhaustion;stem cell niche;stem cells;targeted treatment;Testing;Time;tissue injury;tissue regeneration;tissue repair;Tissues;Transcriptional Coactivator with PDZ-Binding Motif;Undifferentiated;Vesicle;Work

PROJECT_TITLE: Paneth cell plasticity and regeneration

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Cancer;Cardiovascular;Heart Disease

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE The chemotherapeutic drug Doxorubicin has cardiotoxic effects that often lead to heart failure, a leading cause of death and hospitalizations worldwide. Results from this proposal will identify novel contributors to Doxorubicin cardiotoxicity that involve aberrant immune responses and maladaptive remodeling in this deadly type of heart failure.

PI_NAMEs: ZAMBRANO, MARIA ANTONIA (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Antigen-Presenting Cells;Atrophic;Cancer Patient;cancer therapy;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiotoxicity;Cause of Death;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;chemokine;chemotherapy;Communication;coronary fibrosis;cytokine;Data;Development;Doctor of Philosophy;Dose;Doxorubicin;Echocardiography;effective therapy;Female;Fibroblasts;Fibrosis;Functional disorder;gain of function;Gene Expression Profile;Heart;Heart failure;hemodynamics;Histocompatibility Antigens Class II;Histologic;Hospitalization;Immune;Immune response;In Vitro;in vivo;Infection;Infiltration;Inflammation Mediators;Inflammatory;Inflammatory Response;Intercalating Agents;Interferon Type II;Interleukin-6;loss of function;lymphoid organ;male;Malignant Neoplasms;Mentors;Modeling;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;mouse model;Mus;Myocarditis;novel;Pathologic;Patients;Pharmaceutical Preparations;Physiological;Play;Population;preservation;pressure;Production;Proliferating;Reporter;Reporting;Research Personnel;response;Role;side effect;Signal Transduction;stressor;systemic inflammatory response;T cell response;T-Cell Activation;T-cell inflamed;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Tamoxifen;Testing;Therapeutic;Training;Treatment Failure;Trypanosoma cruzi

PROJECT_TITLE: Cardiac fibroblast MHCII contribution to cardiac pathophysiology in Doxorubicin cardiomyopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (20)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

PHR: Project Narrative Carbapenem-resistant Klebsiella pneumoniae is an urgent public health threat with limited available treatments. Central to maintaining long-term treatment efficacy is an improved understanding of the clinical practices, patient populations, and bacterial factors that drive the emergence and spread of resistance. In this proposal, the PI will leverage isolate and data collections from a regional healthcare network before and after the clinical deployment of two recently approved β- lactam/β-lactamase inhibitor combination therapies to understand how baseline clinical practices and circulating bacteria can inform the subsequent emergence and spread of resistance once an antibiotic is clinically deployed.

PI_NAMEs: GONTJES, KYLE JAMES (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: acute care;Admission activity;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic-resistant organism;Antibiotics;Bacteria;bacterial genetics;beta-Lactam Resistance;beta-Lactamase;beta-Lactams;Bioinformatics;California;carbapenem resistance;Carbapenems;career;Case/Control Studies;Categories;Characteristics;Clinical;Clinical Data;clinical practice;Clonal Expansion;Collection;combat;Combined Modality Therapy;Complex;Critical Thinking;Data;Data Analyses;Data Collection;Data Set;drug efficacy;Epidemic;epidemic potential;Epidemiologic Methods;Epidemiology;Evolution;fitness;Follow-Up Studies;Frequencies;Genetic;Genome;genome sequencing;genome wide association study;Genomics;Genotype;Healthcare;hospital care;Imipenem;improved;In Vitro;ineffective therapies;Infection prevention;inhibitor;inhibitor therapy;innovation;insight;Interdisciplinary Study;Intervention;laboratory experiment;Marketing;Measures;Meropenem;Methods;Minimum Inhibitory Concentration measurement;Modification;Multi-Drug Resistance;Mutation;novel;novel therapeutics;Pathway interactions;patient population;Patients;Pattern;Pharmaceutical Preparations;Plasmids;Population;Positioning Attribute;Predisposition;preventive intervention;Program Development;Public Health;Rectum;Reporting;Research;Research Training;Resistance;Resistance development;resistance frequency;resistance mechanism;resistance mutation;resistant Klebsiella pneumoniae;resistant strain;Risk Factors;Role;Scientist;screening;skills;Specimen;Testing;Training Programs;transmission process;Treatment Efficacy;Validation;VDAC1 gene;whole genome;Work

PROJECT_TITLE: Genome-driven identification of patient and bacterial drivers of resistance to novel beta-lactam/beta-lactamase inhibitor combination therapies


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Genetics;Neurosciences;Women's Health Research

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE: Breast cancer is the most common malignancy in women, and the primary cause of breast cancer-related deaths is when tumor cells spread to other organs, a process known as metastasis. Sensory nerves, which are more abundant in breast tumors compared to healthy breast tissue, can increase breast cancer metastasis. The goal of this project is to reveal the mechanisms by which breast cancer cells attract sensory nerves into the tumor, potentially enabling new therapeutic targets to reduce metastasis and improve patient survival.

PI_NAMEs: BLOOMER, HANAN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: 3-Dimensional;Accounting;Adult women;afferent nerve;Afferent Neurons;antagonist;Automobile Driving;Binding Sites;Biological Assay;Breast;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;cancer diagnosis;cancer type;career;Cations;Cause of Death;Cell Culture System;Cell secretion;Cells;Cessation of life;Clinical;clinical training;Coculture Techniques;Complex;density;design;Disease;Disease-Free Survival;Distant;Environment;Exhibits;experimental study;Extracellular Matrix;Fatty acid glycerol esters;Fellowship;Female;Genes;Genetic;Genetic Transcription;Goals;Growth;Human;hydrogel scaffold;Hydrogels;IL6 gene;improved;In Vitro;in vivo;innovation;insight;Interleukin-6;JUN gene;Knock-out;Knockout Mice;Luciferases;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Gland Parenchyma;Mammary Neoplasms;MDA MB 231;Mediating;Metastatic Neoplasm to the Liver;Metastatic Neoplasm to the Lung;Methodology;migration;Modeling;molecular subtypes;Monitor;mortality;mouse model;Mus;Natural regeneration;Neoplasm Metastasis;neoplastic cell;Nerve;Nerve Fibers;nerve supply;Neurites;Neurons;new therapeutic target;novel;novel strategies;Nuclear;Organ;Patient-Focused Outcomes;Patients;Peripheral Nerves;pharmacologic;Physicians;physiologic model;Physiological Processes;pre-doctoral;Process;recruit;Research Proposals;Research Training;Role;Scientist;Secondary to;Sensory;Site;Spinal Ganglia;System;Testing;three-dimensional modeling;Tissues;Training;transcription factor;Transcription Factor AP-1;transcriptomics;triple-negative invasive breast carcinoma;TRPV1 gene;tumor;tumor growth;tumor microenvironment;tumor progression;Up-Regulation;Woman;Work

PROJECT_TITLE: Dissecting the Role of TRPV1 in Triple-Negative Breast Cancer Innervation


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Angelman syndrome (AS) is a neurodevelopmental disorder with a high incidence of debilitating seizures. There is an urgent and unmet clinical need to treat these seizures because they are often refractory to antiepileptic drugs. Here, I propose to identify novel seizure-relevant molecular targets that may inform therapeutic strategies to treat epilepsy in AS.

PI_NAMEs: KRZESKI, JOSEPH  (contact)

PROJECT_TERMS: Affect;Alleles;Angelman Syndrome;anti-epileptic agents;Antisense Oligonucleotides;Ataxia;Biological Assay;cell type;Clinical;clinical development;Clinical Trials;Data;Development;Disease;Epigenetic Process;epigenetic silencing;Epilepsy;Epileptogenesis;experimental study;Face;Future;Goals;Human;In Vitro;in vivo;Incidence;Individual;Inherited;Intellectual functioning disability;Knockout Mice;Knowledge;Label;Ligation;Modeling;Molecular;Molecular Target;mouse model;Mus;Neurodevelopmental Disorder;Neurons;new therapeutic target;novel;novel strategies;novel therapeutics;overexpression;Patients;pharmacologic;Phenotype;Physicians;pre-clinical;Predisposition;Protein Isoforms;Proteins;Quality of life;Recurrence;Refractory;resilience;Resistance;Role;Safety;Seizures;side effect;Sleep disturbances;Symptoms;Testing;Therapeutic;therapeutic development;Toxic effect;treatment strategy;UBE3A gene;ubiquitin-protein ligase;Work

PROJECT_TITLE: The Role of UBE3A Isoforms in AS-associated Seizure Susceptibility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE This award will support the 2024 summer meeting for the Basic Cardiovascular Sciences Council of the American Heart Association. The purpose of this meeting is to allow scientists to exchange information on the basic and translational mechanisms of heart disease to help stimulate collaborations and new investigation. We also promote the careers of emerging scientists and trainees.

PI_NAMEs: ZHANG, JIANYI  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Address;American Heart Association;Arrhythmia;Award;Back;Boston;cardiogenesis;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;career;Chicago;Clinical;Collaborations;Communication;coronary fibrosis;Dedications;design;Discipline;Disease;distinguished professor;diversity and inclusion;Emerging Technologies;Epigenetic Process;Event;exosome;experience;Feedback;Female;Funding;Genetic;Genomics;Geographic Locations;Goals;Health;Heart;Heart Diseases;Heart failure;heart metabolism;Hypertrophy;Immune;International;Investigation;Journals;Knowledge;Leadership;lectures;lipid mediator;Logistics;medical schools;Medicine;meetings;member;Molecular;National Heart, Lung, and Blood Institute;next generation;novel;Oral;Organ;Oxidative Stress;pandemic disease;Participant;Pathogenesis;Pathway interactions;Persons;Physician Executives;Physiology;posters;programs;Protocols documentation;Recurrence;Request for Proposals;Research;Research Personnel;Running;Safety;Schedule;Science;Scientist;Secure;Series;Side;success;symposium;Therapeutic;Time;Tissue Engineering;Translations;virtual;Woman;Work

PROJECT_TITLE: Advances in Cardiovascular Science: From Discovery to Translation


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Epilepsy;Health Services;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: STANFORD

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: Seizures are one of the most common reasons why bystanders call an ambulance for a child, and current practice frequently fails due to under-dosing and delayed delivery of anti-seizure medication (midazolam). Reducing the respiratory failure and brain damage that this causes requires equipping paramedics with a simplified method for rapidly determining and administering a therapeutic dose of medication. If this study demonstrates that standardized, age-based midazolam dosing is both safe and more effective than current practice, the potential impact of this study is a paradigm shift in the treatment of pediatric seizures that can be easily implemented in emergency medical services (EMS) systems across the country.

PI_NAMEs: SHAH, MANISH ISHWAR (contact)

PROGRAM_OFFICER_NAME: BROWN, JEREMY

PROJECT_TERMS: Accident and Emergency department;Address;Adherence;adverse outcome;Age;Ambulances;Anticonvulsants;Applied Research;Area;Benzodiazepines;Brain Injuries;Breathing;care systems;Caring;Child;Childhood;conventional dosing;Country;design;Dose;Early treatment;Effectiveness;Electroencephalography;Emergency Care;Emergency medical service;evidence based guidelines;Frequencies;Goals;Guideline Adherence;Hospitals;improved;improved outcome;Injections;innovation;Intramuscular;Intravenous;Literature;Manuscripts;Measures;Midazolam;Morbidity - disease rate;mortality;Multicenter Studies;Muscle;Nose;novel;Outcome;Outcomes Research;Overdose;Paramedical Personnel;pediatric emergency;pediatric patients;Pharmaceutical Preparations;Pre-hospital setting;primary outcome;Protocols documentation;rapid technique;Recommendation;Rectum;Recurrence;Regimen;Research;Research Priority;Respiratory Failure;response;Risk;Route;Safety;Seizures;Standardization;System;Technology;Testing;Therapeutic;Treatment Effectiveness;Weight

PROJECT_TITLE: Pediatric Dose Optimization for Seizures in EMS (PediDOSE)


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Data Science;Dental, Oral, and Craniofacial Disease;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE The Common Fund program brings together diverse collections of valuable biomedical datasets capable of facilitating discovery and enabling future innovation. As a central hub of protein sequence and functional information, the UniProt will partner with the Common Fund Data Ecosystem resources to support data integration and reuse and build new capabilities to interrogate and understand complex biological systems and cell networks. Our deeper understanding of responses to perturbations at the systems level will accelerate the development of new diagnostics and therapies and overall health-related research and discovery.

PI_NAMEs: BATEMAN, ALEX ;WU, CATHY H. (contact)

PROGRAM_OFFICER_NAME: KINSINGER, CHRISTOPHER

PROJECT_TERMS: Acceleration;Adopted;Amino Acid Sequence;Biological Markers;biological systems;biomedical resource;Bridge to Artificial Intelligence;Case Study;Cells;Collaborations;Collection;Communities;Complex;complex biological systems;Conceptions;crosslink;Data;Data Coordinating Center;data ecosystem;data integration;data interoperability;data repository;data resource;data reuse;Data Set;design;Development;drug discovery;Ecosystem;Educational workshop;Enzyme Inhibitor Drugs;Feedback;Fostering;functional genomics;Funding;Future;Genes;Genotype;Health;improved;innovation;interest;interoperability;Investments;Knockout Mice;Knowledge;knowledge curation;knowledge graph;knowledge hub;knowledge integration;learning algorithm;Life;Life Cycle Stages;Link;Literature;Maintenance;Maps;Metabolic;Molecular;mouse model;multiscale data;new therapeutic target;novel;novel diagnostics;novel therapeutics;Pathway interactions;Pharmaceutical Preparations;Phenotype;Post-Translational Protein Processing;predictive modeling;programs;protein function;Proteins;public database;Research;Research Personnel;Resources;response;Services;Signal Transduction;Structure;System;text searching;tool;tool development;web site;Work

PROJECT_TITLE: UniProt Partnerships with Common Fund Data Ecosystem Resources for Protein-Centric Functional Genomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-E (56)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Obesity;Schizophrenia;Serious Mental Illness

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Individuals with schizophrenia and related psychotic disorders have greatly increased rates of obesity and obesity-related comorbidities, compared to the general population. A major factor impeding the development of effective treatments for this major health concern is the limited understanding of the underlying neurobiological mechanisms. This proposal attempts to address this knowledge gap by examining the relationship between obesity in schizophrenia and brain connectivity disruptions found in both schizophrenia and obesity in the general population.

PI_NAMEs: DODD, KEITH  (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Address;Affect;Antipsychotic Agents;Behavior;Biology;Brain;burden of illness;Cardiovascular Diseases;career;Clinical;Colorado;Communication;comorbidity;comparison group;Consumption;craving;Cues;Data;Data Set;Desire for food;Development;Diabetes Mellitus;Disinhibition;Eating;Eating Behavior;effective therapy;executive function;exercise intervention;Fasting;Food;Functional disorder;Functional Magnetic Resonance Imaging;Future;General Population;ghrelin;Goals;Health;Hormones;Hunger;improved;Incidence;Individual;Insulin;Knowledge;Leptin;Machine Learning;Malignant Neoplasms;Measurement;Measures;Medical;Mental Depression;Mental disorders;Mentors;Moods;neurobiological mechanism;Neurobiology;neuroimaging;Neurons;Obesity;obesity risk;obesogenic;Overweight;Pattern;Physicians;Population;Prevalence;Psychiatry;Psychotic Disorders;Research;Resources;response;Rest;restraint;Risk;Schizophrenia;Scientist;Severities;Symptoms;theories;therapy development;Training;trait;Universities;Visual;Weight Gain

PROJECT_TITLE: Triple-network connectivity contributions to obesity in Schizophrenia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DAVIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The proposed project will evaluate the association of lifecourse obesity with cognitive decline and Alzheimer’s Disease and related dementias (ADRD) in a cohort of racially and ethnically diverse older adults. Findings from this project will address survival, selection, and competing risk biases to better understand the etiological role obesity has on ADRD and cognitive decline at different periods over the lifecourse.

PI_NAMEs: MEUNIER, CLAIRE CHRISTIANE (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;Adolescent;adult obesity;African American population;Age;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Asian;Biological;Black race;Body mass index;brain health;career;Categories;clinical examination;Cognition;Cognitive;cognitive change;cohort;Cohort Studies;Data;dementia risk;Disparity;early adolescence;Epidemiologic Methods;Epidemiology;ethnic diversity;Etiology;Event;Fellowship;Gender;gender difference;gender disparity;Goals;Hazard Models;Health;health record;healthy aging;Height;high risk;Impaired cognition;knowledge base;late life;Latino;Life course epidemiology;Life Cycle Stages;Life Experience;Longitudinal cohort study;Measurement;Measures;Mediating;Mediation;member;men;Mentors;Methodology;Methods;middle age;Modeling;modifiable risk;mortality risk;Neuropsychology;Obesity;obesity risk;observational cohort study;older adult;Outcome;Overweight;Participant;Pathway interactions;Pattern;Persons;Population;Population Heterogeneity;pre-doctoral;Prevalence;Probability;protective factors;Protocols documentation;Public Health;racial diversity;Research;Research Methodology;Research Personnel;Risk;Risk Factors;Role;Selection Bias;sex;sex variable;skills;Spanish/English;study population;Time;Training;Underweight;Weight;Woman

PROJECT_TITLE: Addressing biases and evaluating gender differences in lifecourse obesity and risk of ADRD in a diverse cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The Women’s Health Initiative Dietary Modification (DM) Trial randomized 48,835 postmenopausal women to an intervention group (DM-I) whose participants followed a low-fat/high fruit and vegetable dietary pattern or a usual diet comparison group (DM-C). Following the ~8.5 y intervention, women in the DM-I experienced numerous clinically meaningful intervention effects on important measures of metabolic health and long-term health and mortality outcomes. Leveraging data and samples from the trial, we will measure metabolomics biomarkers in baseline and year 1 blood from n=1000, and end-of-intervention blood from n=465 WHI-DM participants to identify metabolites and biochemical pathways that explain the clinically meaningful effects of the intervention.

PI_NAMEs: LAMPE, JOHANNA W;NEUHOUSER, MARIAN L (contact)

PROGRAM_OFFICER_NAME: HERRICK, KIRSTEN ANNE

PROJECT_TERMS: 2 arm randomized control trial;Address;Affect;Age-associated memory impairment;Archives;arm;Biochemical Pathway;Biological;Biological Markers;biological specimen archives;Biology;biomarker discovery;Blood;Body Composition;Body mass index;Body measure procedure;Body Weight;Body Weight decreased;Breast;breast cancer diagnosis;Calibration;cancer risk;Carbohydrates;Cessation of life;Chronic Disease;Clinical;clinical center;Collaborations;Colorectal;Colorectal Cancer;Comparison arm;comparison group;Coronary heart disease;Data;density;design;diabetes risk;Diastolic blood pressure;Diet;Diet Modification;dietary;Dietary Factors;Dietary Fats;Dietary Practices;Disease Outcome;Early Diagnosis;Endometrial;experience;Fatty acid glycerol esters;feeding;follow-up;fruits and vegetables;Funding;Glucose;Goals;Grain;Grant;group intervention;Health;heart disease risk;Hypertension;Incidence;insight;Insulin;Insulin Resistance;Intervention;intervention effect;Investigation;LDL Cholesterol Lipoproteins;lipidome;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Measures;Mediating;Mediation;Metabolic;Metabolic Pathway;Metabolic syndrome;metabolome;metabolomics;Modeling;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Obesity;Observational Study;older women;Outcome;Participant;Pathway interactions;Phenotype;Physical activity;Plant Proteins;Postmenopause;Randomized;randomized trial;recruit;Research;Risk;Risk Factors;Risk Reduction;Role;Sampling;Serum;small molecule;Specific qualifier value;stable isotope;Testing;Thinness;treatment arm;Urinary Incontinence;waist circumference;Weight;Woman;Women's Health;Women's trial

PROJECT_TITLE: Nutrition and Physical Activity Assessment Study (NPAAS)

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE This project is designed to fill a gap in our understanding about how the muscle cells of the right ventricle grow in fetal hearts with reduced left ventricular inflow, as occurs in hypoplastic left heart syndrome, and how we can improve this growth. Completion of the project will help us know and shape the forces that determine the cardiomyocyte endowment of the right ventricle, which is destined to be the systemic ventricle for life.

PI_NAMEs: JONKER, SONNET SKY (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: 15 year old;Adult;Affect;Anatomy;Apoptosis;Atrial Natriuretic Factor;Birth;Brain natriuretic peptide;Cardiac;Cardiac Myocytes;Cell Count;Cell Cycle;Cell Death;Cessation of life;Child;Chronic;Clinical;congenital anomaly;design;Development;Echocardiography;Endowment;experience;fetal;Fetal Heart;Fetal Sheep;Fetus;Fibrosis;Functional dependence;Goals;Growth;Heart;Heart Atrium;Heart failure;heart function;hemodynamics;high risk infant;Hormonal;Human;Hypertrophy;Hypoplastic Left Heart Syndrome;Impairment;improved;in utero;in vivo;innovation;instrument;Insulin-Like Growth Factor I;Interruption;Intervention;Knowledge;Left;Life;Modeling;Molecular Analysis;Monitor;Muscle Cells;myocardial damage;Natriuretic Peptides;Operative Surgical Procedures;Output;Pathologic;Pathology;Pattern;Performance;Periodicity;Physiological;postnatal;Pregnancy;Primary Cell Cultures;Process;Proliferating;receptor;Regulation;Reproducibility;Research Personnel;resilience;response;right ventricular failure;Right ventricular structure;Risk;Sampling;sham surgery;Shapes;Sheep;sheep model;Signal Transduction;Stress;Stretching;Stroke Volume;Techniques;Testing;Therapeutic;therapy development;Time;Tissues;Tricuspid valve structure;Ventricular;Work

PROJECT_TITLE: Regulation of cardiomyocyte growth in a fetal ovine model of reduced left ventricular filling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-C (02)]


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Idiopathic Pulmonary Fibrosis (IPF) is a progressive and fatal fibrotic lung disease with no known cure, resulting in respiratory failure and a median survival of only 3-5 years. Our preliminary data suggest a potential role of the Notch signaling pathway in the differentiation of lung alveolar epithelial cells (AECs), a regenerative process that becomes disrupted in the development of IPF. This project aims to investigate whether AECs utilize the Notch pathway to restore the alveolar epithelium after injury and, in doing so, will provide novel insight into potential therapeutic targets in the Notch pathway that may be leveraged to inform the development of curative IPF therapies.

PI_NAMEs: LIANG, JESSICA  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Adult;Alveolar;alveolar epithelium;Attenuated;beta catenin;Binding;Bleomycin;Cell Differentiation process;Cell Line;Cell Proliferation;cell regeneration;Cells;Cessation of life;chromatin immunoprecipitation;Cicatrix;Clustered Regularly Interspaced Short Palindromic Repeats;conditional knockout;CTNNB1 gene;curative treatments;Data;Data Set;Defect;Deterioration;Development;Disease;Disease Progression;Down-Regulation;Epithelial Cells;epithelium regeneration;ES01;ES04;fetal;Fibrosis;fibrotic lung disease;Foundations;Gases;Genes;Genetic Transcription;Human;human induced pluripotent stem cells;idiopathic pulmonary fibrosis;Immunofluorescence Immunologic;Impairment;improved;In Vitro;in vivo;inhibitor;Injury;insight;Instruction;Knock-out;Knockout Mice;Knowledge;Label;Laboratories;Ligands;Lipopolysaccharides;loss of function;Lung;Lung Diseases;lung injury;Measures;Mediating;Modeling;Morphology;mouse model;Mus;Natural regeneration;neutralizing antibody;notch protein;Notch Signaling Pathway;novel;Organ;Organoids;paralogous gene;Pathogenesis;Pathologic;Pathway interactions;Patient-Focused Outcomes;Physiological;Play;Predisposition;Printing;Process;Promoter Regions;Proteins;pulmonary function;Pulmonary Surfactants;receptor;regenerative;Reporter;Reporting;Repression;Respiratory Failure;restoration;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stains;stem;stem cell organoids;stem cells;Structure;Surface;Surface Tension;surfactant;System;targeted treatment;Testing;therapeutic target;Thinness;transcription factor;transcriptome;Type I Epithelial Receptor Cell

PROJECT_TITLE: Elucidating the Role of Notch/HES Signaling in Alveolar Epithelial Type II to Type I Cell Differentiation


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHARLESTON

ORG_DEPT: PEDIATRICS

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Loss of P53 activity triggers the activation of cell type-specific signaling networks, a number of which become tumor drivers. Here, I propose to identify those P53-dependent pathways to which the TRP53 mutant SHH subgroup medulloblastoma tumors have become addicted and elucidate their mechanism of action.

PI_NAMEs: RODRIGUEZ-BLANCO, JEZABEL  (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: antagonist;Attenuated;Bioinformatics;Brain;Brain Neoplasms;Cancer Etiology;cancer stem cell;candidate identification;Cell Proliferation;cell type;Cells;Cessation of life;Chemoresistance;Child;Childhood Brain Neoplasm;childhood cancer mortality;Classification;Clinic;Clinical stratification;Clinical Trials;Data;design;Development;Ensure;Family;Family member;Future;Genomic approach;Genomic Instability;Genomics;GLI gene;GLI2 gene;Goals;Growth;Heterogeneity;high risk;Human;in vivo;inhibitor;knock-down;Malignant Neoplasms;Medulloblastoma;Mentors;Modeling;Molecular;Molecular Genetics;mouse model;Mus;mutant;Mutation;novel;novel therapeutics;Oncogenes;Outcome;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Physicians;Play;Prediction of Response to Therapy;Process;Prognosis;Proteins;Publishing;Recurrence;Relapse;Research;Role;Screening Result;self-renewal;SHH gene;side effect;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;small molecule;smoothened signaling pathway;Sonic Hedgehog Pathway;standard of care;stem;stemness;Stratification;Subgroup;success;Technology;Therapeutic;therapy design;therapy resistant;Tissues;TP53 gene;Transcript;transcription factor;Transcriptional Activation;transcriptome;tumor;tumor growth;tumor initiation;Tumor Suppressor Genes;tumorigenic;Ubiquitin;Untranslated RNA;Work

PROJECT_TITLE: Identifying Novel Therapeutics for High Risk Medulloblastoma Patients

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: NUTRITION

PHR: PROJECT NARRATIVE Water creates an enabling environment for good nutrition but the ways by which water insecurity negatively impacts diet and health are not known. This proposed project uses qualitative and quantitative data from 2 islands with substantial water issues to understand if and how water insecurity, an increasingly common public health issue, contributes to poor diet quality and adverse changes in body composition. Findings from this project have the potential to identify upstream determinants of nutrition that can be targeted to address growing global malnutrition.

PI_NAMEs: MILLER, JOSHUA D (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Age;Agriculture;Body Composition;Body fat;Body mass index;Breast Feeding;career;Caregivers;Child;Childhood;Cohort Studies;Communicable Diseases;comparative;Complement;Consumption;cooking;Data;Development;Diet;dietary;dietary guidelines;Dimensions;Discipline;Disease;early childhood;Eating;Ecuador;Educational Curriculum;enteric pathogen;Environment;Epidemiologic Methods;Epidemiology;Equation;experience;Exposure to;Family;Focus Groups;Food;food environment;food insecurity;food preparation;Food production;Future;Gastrointestinal Diseases;Growth;Health;Health Surveys;Home;Household;improved;Income;indexing;Individual;infancy;Infant;innovation;Intake;Interview;Island;Knowledge;lens;Life Cycle Stages;Malnutrition;Measures;Mentorship;Methods;Modeling;multilevel analysis;Nutrient;nutrition;Nutrition Surveys;Nutritional;Obesity;Overweight;Pathway interactions;Personal Satisfaction;Philippines;Physical activity;Preparation;Procedures;Process;Production;Public Health;Reporting;Research;Research Personnel;Resources;Risk;Role;Safety;Secure;Site;skills;Structure;sugar;Surveys;sweetened beverage;Systems Biology;Techniques;Time;Unhealthy Diet;United States;Water;water quality;waterborne pathogen;Weight Gain;well water;Work

PROJECT_TITLE: Differential impacts of water insecurity on diet and body composition throughout the life course

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Abnormal activation of the complement pathway, which regulates innate immunity and inflammation, is associated with blinding diseases such as inherited and age-related macular degenerations. This research will investigate how a novel pathway of intracellular complement activation endangers the health of the retinal pigment epithelium, a key site of insult in macular degenerations. We will study the impact of intracellular complement on the function and integrity of the retinal pigment epithelium, and identify potential points of therapeutic intervention that can be targeted to preserve vision.

PI_NAMEs: LAKKARAJU, APARNA  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Age related macular degeneration;ATP binding cassette transporter 1;Atrophic;Autophagocytosis;Biogenesis;Blindness;Cell Physiology;Cells;Ceramides;Cholesterol;cholesterol transporters;Chronic;Complement;Complement Activation;complement pathway;complement system;Data;Defect;design;Development;Disease;disease model;Drusen;Early Endosome;Endosomes;Equilibrium;extracellular;Extracellular Space;FRAP1 gene;Functional disorder;Generations;Genes;Genetic Polymorphism;Health;Homeostasis;Human;Image;Inflammation;Inflammatory;Inherited;Injury;innovation;insight;Link;Lipofuscin;live cell imaging;Location;Macular degeneration;Mediating;Metabolic;Metabolism;Mitochondria;Modeling;Molecular;mouse model;Mus;Natural Immunity;novel;Pathogenicity;Pathologic;Pathology;Pathway interactions;Peptide Hydrolases;photoreceptor degeneration;Play;Precision therapeutics;preservation;prevent;Process;programs;Proteolysis;receptor;Receptor Activation;Receptor Inhibition;Receptor Signaling;Recycling;Research;Retina;Retinal Degeneration;Retinal Diseases;Role;Secondary to;segregation;Signal Transduction;Site;Speed;Stress;Structure of retinal pigment epithelium;Swelling;Therapeutic;Therapeutic Intervention;therapeutic target;trafficking;ultra high resolution;uptake;Vision

PROJECT_TITLE: Mechanisms of RPE dysfunction in macular degenerations: role of intracellular complement activation

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: Diabetes;Obesity

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

PHR: Excessive weight increases risk for development of prediabetes and type-2 diabetes, due in part to impairments in skeletal muscle metabolism. This project will provide new understanding of the mechanisms and therapeutic potential of using sodium-glucose cotransporter-2 (SGLT2) inhibition as a treatment for impairments to skeletal muscle metabolism associated with weight gain and obesity.

PI_NAMEs: ROBINSON, MATTHEW MCHUTCHESON (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acute;Address;Bioenergetics;Cardiometabolic Disease;Cells;Chronic;clinically relevant;Complex;Consumption;Data;design;Development;disorder risk;Dose;Excretory function;Fatty acid glycerol esters;FDA approved;Glucose;glucose disposal;glucose metabolism;glucose uptake;GLUT 4 protein;Goals;Health;Health Benefit;human model;Impairment;improved;Inflammatory;inhibitor;Insulin;insulin signaling;Kidney;Knock-out;Knowledge;Lipids;Liver;loss of function;Metabolic;Metabolism;Metformin;Mitochondria;mitochondrial metabolism;Modeling;mouse model;Mus;Muscle;Muscle Cells;Muscle Mitochondria;NADH dehydrogenase (ubiquinone);Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesogenic;Outcome;oxidation;Pharmaceutical Preparations;Prediabetes syndrome;Proteins;Regulation;Reporting;Respiratory physiology;Risk;Role;Signal Transduction;Skeletal Muscle;skeletal muscle metabolism;Sodium;Stress;symporter;Testing;Therapeutic;Tissues;Treatment Efficacy;treatment strategy;urinary;Weight Gain;western diet;Work

PROJECT_TITLE: Mechanism by which SGLT2 inhibitor treatment regulates skeletal muscle fuel metabolism

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]