NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Lung;Patient Safety

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative This project seeks to use a combination functional lung imaging and inflammatory biomarker assessment to more comprehensively interrogate the lung's response to bronchoscopic volumetric reduction as a treatment for late-stage emphysema. Through a better understanding of the alterations in ventilation, perfusion, and inflammatory burden that this intervention precipitates-and which are assumed to be the primary mechanisms through which it improves lung function-we will also address the discrepancy which many patients experience between the achievement of clinically significant functional gains and the failure to experience a commensurately improved quality of life.

PI_NAMEs: RIZI, RAHIM R (contact)

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: Achievement;Acute;Address;Aftercare;Air;Air Movements;Airway Disease;airway obstruction;Alveolar;analog;Anatomy;Atelectasis;Biological Markers;Blood;Blood flow;Blood gas;Body Composition;Catheters;CD8-Positive T-Lymphocytes;Cells;Chronic;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Markers;clinically relevant;clinically significant;comparative efficacy;Compensation;Coughing;Deterioration;Dyspnea;Effectiveness;Erythrocytes;Evaluation;exercise capacity;experience;Extravasation;Failure;functional decline;functional gain;Functional Imaging;functional improvement;functional loss;Functional Residual Capacity;functional restoration;Future;Gases;Heterogeneity;Hypoxemia;Hypoxia;Image;imaging biomarker;imaging modality;improved;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Intervention;Legal patent;Life;Lobar;Lobe;Lung;lung imaging;lung injury;Lung volume reduction surgery;Lung Volume Reductions;Macrophage;Magnetic Resonance Imaging;Maps;Masks;Measurement;Measures;Mechanics;Medical;Modeling;Morbidity - disease rate;mortality;novel;Outcome Measure;Oxygen;Patient Selection;Patient-Focused Outcomes;Patients;Perfusion;Perioperative;perioperative morbidity;perioperative mortality;Phase;Physiological;post intervention;prevent;Pulmonary Emphysema;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary Gas Exchange;Pulmonary Inflammation;Quality of life;Quality of Life Assessment;Reporting;Residual state;Residual volume;Resolution;Respiratory Mechanics;response;Shortness of Breath;Signal Transduction;smoking cessation;Source;Spirometry;Structure of parenchyma of lung;success;symptom treatment;systemic inflammatory response;Techniques;Therapeutic;Therapeutic Intervention;Tissues;treatment duration;Treatment Efficacy;uptake;ventilation;Xenon

PROJECT_TITLE: Imaging the functional response of the lung to bronchoscopic lung volume reduction

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Despite significant advances in preventative therapies for coronary heart disease, there is a significant residual burden of disease, in part due to the role of vascular inflammation in the development of atherosclerosis. The goal of this proposal is to delineate new pathways contributing to the inflammatory risk in atherosclerosis using an integrative omics approach, combining emerging proteomic profiling techniques, human genetics, bioinformatics and small animal models of disease.

PI_NAMEs: TAHIR, USMAN A. (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Advisory Committees;AKT Signaling Pathway;Animal Disease Models;Animal Model;Area;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Back;Basic Science;Bioinformatics;Biological;Biological Markers;Biological Models;Biology;biomedical informatics;Bone Marrow;burden of illness;Cardiovascular Diseases;Cardiovascular system;catalyst;CD36 gene;cell motility;chemokine;Chemotaxis;Chronic;cohort;Computational Science;Control Animal;Coronary heart disease;Data;Databases;design;Development;Developmental Process;Discipline;Disease;disease model;Disease Pathway;Epidemiology;Foam Cells;follow-up;FRAP1 gene;Functional disorder;functional genomics;Future;Generations;Genetic;genetic analysis;Genetic Databases;genetic variant;Genomics;Goals;Hematopoiesis;Homologous Gene;Human;Human Genetics;In Vitro;in vivo;Inflammation;Inflammatory;insight;instructor;instrument;Integral Membrane Protein;Investigation;Israel;Jackson Heart Study;K-Series Research Career Programs;Knockout Mice;laboratory experience;Lesion;Leukocytes;Macrophage;Mediating;Mediator;Medical center;medical schools;Medicine;Mendelian randomization;Mentors;Mentorship;Molecular Profiling;monocyte;mortality;mouse model;Mus;novel;oxidized low density lipoprotein;Participant;Pathway interactions;Phagocytosis;PIK3CG gene;Pilot Projects;Plasma;Predisposition;Preventive therapy;Preventive treatment;Process;progenitor;Proliferating;Proteins;Proteome;Proteomics;Proto-Oncogene Proteins c-akt;Proxy;Publishing;Recombinants;recruit;Research;Residual state;Risk;Risk Factors;Role;Sepsis;Signal Transduction;skills;Systems Biology;Techniques;Technology;Testing;Training;training opportunity;Training Programs;Translating;uptake;vascular inflammation;western diet;Work

PROJECT_TITLE: The Role of SECTM1 in Monocyte Biology and Atherosclerosis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Adolescent Sexual Activity;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: 2. PROJECT NARRATIVE Adolescence is a critical developmental period in which alcohol use and sexual violence often first occur, and sex disparities in these outcomes emerge. Through the proposed K01 career development training and research, the candidate will build expertise in social and developmental psychology, adolescent alcohol epidemiology, and advanced statistical techniques to examine the ways in which gender expression and related socialization processes operate within adolescent social networks and explain the onset of and sex-disparities in alcohol use and sexual violence. Findings will identify the mechanisms underlying these interconnected public health problems in adolescence and will inform prevention efforts to address alcohol use disorders and sexual re- victimization during adulthood, ultimately reducing the considerable social, economic, and medical costs associated with these public health crises to the US healthcare system and society.

PI_NAMEs: BARKER, KATHRYN M (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adherence;Adolescence;Adolescent;Adult;Affect;Age;Alcohol abuse;Alcohol consumption;alcohol epidemiology;alcohol measurement;alcohol risk;alcohol use disorder;alcohol use initiation;Alcohols;Algorithms;American;Behavior;Behavioral;Belief;career development;Cohort Studies;critical developmental period;critical period;Data;Data Set;Dedications;design;deter alcohol use;Development;developmental psychology;drinking behavior;economic cost;Empirical Research;Environment;Epidemiology;epidemiology study;Equation;Ethnic Origin;Etiology;expectation;Female;Forcible intercourse;Future;Gender;gender expression;gender minority status;Goals;Growth;Health;health disparity;Healthcare Systems;high risk;improved;Individual;Influentials;innovation;insight;Intervention;Life Cycle Stages;Link;Longitudinal Studies;male;Measures;Mediating;Medical Care Costs;men;Mentored Research Scientist Development Award;Mentors;Modeling;multilevel analysis;National Institute on Alcohol Abuse and Alcoholism;National Longitudinal Survey of Adolescent to Adult Health;Neighborhoods;novel;Outcome;Pathway Analysis;Pattern;peer;Peer Group;peer influence;Peer Pressure;Perception;Play;Population;Prevalence;prevent;Prevention;Prevention Research;Probability;Process;Prospective, cohort study;psychologic;Public Health;Race;racial minority status;Reporting;Research;Research Activity;Research Personnel;revictimization;Risk;Risk Behaviors;Role;Sampling;Schools;Science;Scientist;sex;Sex Behavior;sex disparity;Sexual and Gender Minorities;sexual minority status;sexual violence;Shapes;social;social determinants;social engagement;Social Environment;social epidemiology;Social Interaction;Social Network;social norm;Social Processes;Social Psychology;social structure;Socialization;Societies;Strategic Planning;Subgroup;Surveys;Survivors;Techniques;Time;Training;Typology;underage drinking;United States;Variant;Violence;Woman;Work;Youth

PROJECT_TITLE: Social Network Dynamics of Adolescent Gender Socialization, Alcohol Use, and Sexual Violence

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE In order to meet future public health needs of the nation this educational training program provides exceptional research training to MD, MD Ph.D or PhD trainees in adult and pediatric rheumatology and immunology to study autoimmunity and rheumatic diseases. It will train the next generation of translational and clinical research investigators to take advantage of new breakthroughs in understanding disease pathophysiology and the resultant potential for development of innovative therapy in both adult and pediatric rheumatic diseases.

PI_NAMEs: LEWIS, DAVID BRAM (contact);ROBINSON, WILLIAM H

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Training Program in Adult and Pediatric Rheumatology


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Cancer is major socio-economic problem in the United States, with annual estimates at 1.7 million new diagnoses, over 600,000 cancer-related deaths, and health care costs exceeding 125 billion dollars. The focus of this proposal is to develop novel approaches that modulate selective host-microbiota interactions to limit tumor progression and improve the efficacy of checkpoint inhibitors in colorectal cancer.

PI_NAMEs: SONNENBERG, GREGORY F (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: adaptive immunity;Address;anti-PD1 therapy;Automobile Driving;beneficial microorganism;Cancer Model;cancer type;Cells;Cessation of life;checkpoint therapy;Colorectal Cancer;cytokine;Cytoprotection;Data;Evolution;exhaustion;Exhibits;experimental study;Failure;Frequencies;Functional disorder;Genomic Instability;gut inflammation;gut microbiota;Health;Health Care Costs;Histocompatibility Antigens Class II;Homeostasis;host microbiota;host-microbe interactions;Human;human model;immune checkpoint blockade;Immune checkpoint inhibitor;Immunity;Immunologics;Immunotherapy;Impairment;improved;Infection;Inflammation;Intervention;Intestines;Invaded;Knowledge;Lymphocyte;Lymphoid Cell;Malignant Neoplasms;Microbe;microbial;microbiota;microbiota composition;Molecular;mouse model;Mus;neoplasm immunotherapy;Newly Diagnosed;novel;novel strategies;novel therapeutic intervention;pathogen;Pathway interactions;phenotypic biomarker;Population;prevent;Publishing;Regulation;Resistance;response;Role;Seminal;Shapes;socioeconomics;success;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;transcription factor;Tumor Cell Invasion;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;United States;Vaccination

PROJECT_TITLE: Innate lymphoid cell regulation of the host-microbiota interactions in cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Immunization;Infectious Diseases;Networking and Information Technology R&D (NITRD);Vaccine Related

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: This proposal aims to develop novel algorithms to better characterize the full spectrum of molecular, cellular, and phenotypic changes that occur in B cells using single cell RNAseq and spatial transcriptomics data.

PI_NAMEs: KHAN, ALY AZEEM (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Achievement;Address;Affinity;Algorithm Design;Algorithms;Antibodies;Antibody Affinity;Architecture;Autoimmunity;B-Cell Antigen Receptor;B-Lymphocytes;Biological;biological systems;biomarker identification;Cell Compartmentation;Cell model;Cells;Clinical;Collaborations;Communicable Diseases;Complex;complex data;Computational algorithm;Computational Technique;computerized tools;Computing Methodologies;Data;Data Set;Development;Developmental Process;Dimensions;Disease;Functional disorder;Gene Expression;Genetic Transcription;Gut associated lymphoid tissue;Health;Heterogeneity;Histologic;Histology;Hypersensitivity;Image;Immune;Immune response;Immune signaling;Immune system;Immunoglobulin Class Switching;Immunoglobulin Constant Region;Immunoglobulin Switch Recombination;Immunology;improved;Individual;Infection;innovation;insight;Knowledge;Location;Lymphoid Tissue;Maps;Measures;Mediating;Methods;Modeling;Modernization;Molecular;novel;Output;Pathway interactions;Phenotype;predictive marker;programs;Research;Research Personnel;response;RNA;Role;Sampling;single-cell RNA sequencing;Slice;Stains;Systems Biology;Techniques;Technology;therapeutic target;Time;Tissues;tool;transcriptomics;Vaccination;vaccine response;Vaccines;Work

PROJECT_TITLE: Unraveling the functional diversity of B cells in health and disease


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE: The molecular mechanisms underlying how the alcohol intoxication experience is remembered as rewarding are poorly understood. This work will reveal a transcriptional pathway through which alcohol alters gene expression, altering reward circuit dynamics. This will further inform how alcohol co-opts the brain’s natural reward circuits to result in alcohol cravings.

PI_NAMEs: KAUN, KARLA R. (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acute;Affect;alcohol behavior;alcohol craving;alcohol exposure;alcohol memory;alcohol reward;alcohol seeking behavior;alcohol use disorder;Alcoholic Intoxication;Alcohols;Animals;approach behavior;Automobile Driving;Behavior;behavior influence;Behavioral;Binding;Brain;Calcium;Cardiovascular Diseases;cell type;Cells;Chronic;chronic alcohol ingestion;cofactor;Confusion;Cue-induced relapse;Cues;Data;Development;Dopamine;Dopamine Receptor;dopaminergic neuron;Dose;Drosophila genus;Drosophila melanogaster;drug of abuse;Embryonic Development;Event;Exclusion;experience;extracellular;forward genetics;Future;Gene Expression;Genes;Genetic;genetic approach;genetic manipulation;Genetic Transcription;Goals;Immune Response Genes;Immune System Diseases;Intoxication;Kidney Diseases;learned behavior;Liver diseases;Malignant Neoplasms;Measures;member;Memory;memory encoding;Molecular;neural;neural circuit;Neurodegenerative Disorders;Neuronal Plasticity;Neurons;notch protein;Notch Signaling Pathway;novel;Pathway interactions;pharmacologic;Pharmacological Treatment;Play;postsynaptic;Process;Property;Protein Isoforms;Proteins;receptor;receptor expression;Regulation;Relapse;relapse prevention;Respiratory Disease;response;Rewards;Role;sensor;Sensory;Serine;Shapes;Signal Transduction;Social Behavior;Specificity;Synapses;Testing;tool;Transcript;Visualization;Withdrawal;Work

PROJECT_TITLE: Notch-dependent microcircuit regulation of alcohol reward memory

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: PHOENIX

ORG_NAME: BANNER HEALTH

ORG_STATE: AZ

PHR: Project Narrative Lewy body dementia (LBD), encompassing dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD), is the second most common cause of dementia, and both are caused by abnormal aggregation and accumulation of a protein, α-synuclein (aSyn), in the brain. At present, advances in the treatment of these conditions are critically hampered by the lack of non-invasive, inexpensive biomarkers that can provide accurate diagnostic and prognostic information. This project will assess aSyn in punch biopsies of the skin, using new “seeding assay” diagnostic methods performed by two independent laboratories.

PI_NAMEs: ADLER, CHARLES H;BEACH, THOMAS G (contact);KANTHASAMY, ANUMANTHA GOUNDER

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: accurate diagnostics;Affect;Aging;alpha synuclein;Arizona;Autopsy;Biological Assay;Biological Markers;Biopsy;Blinded;Brain;Clinic;Clinical;Clinical dementia rating scale;Clinical Trials;Cognition Disorders;Cognitive;cognitive testing;Cutaneous;Data;Dementia;Dementia with Lewy Bodies;density;Diagnosis;diagnostic assay;Diagnostic Procedure;Diagnostic Sensitivity;Diagnostic Specificity;Diagnostic Trial;diagnostic value;Disease;Disease Progression;Enrollment;Health;imaging modality;Immunohistochemistry;Iowa;Laboratories;Lewy Body Dementia;Longevity;Measures;Methods;Molecular;Monitor;Motor;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Movement Disorders;Needle biopsy procedure;Nerve Degeneration;Neurodegenerative Disorders;neuropathology;Parkinson's Dementia;Parkinsonian Disorders;Peripheral;Population;Positron-Emission Tomography;Process;prognostic;prognostic value;protein aggregation;protein misfolding cyclic amplification;Proteins;Public Health;Publishing;Punch Biopsy;Research Institute;response;Sensitivity and Specificity;Severities;Site;Skin;skin biopsy;Specificity;Submandibular gland;Surveys;targeted treatment;Testing;Time;Tissues;Universities;Work

PROJECT_TITLE: Blinded Comparison of Different Alpha-Synuclein Seeding Assays as Cutaneous Biomarkers of Lewy Body Dementias


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Patient Safety;Prevention;Radiation Oncology

ORG_NAME: NRG ONCOLOGY FOUNDATION, INC.

PHR: NRG Oncology NCORP research will significantly impact cancer prevention, screening, control and care delivery, and bring state-of-the-art treatment trials to community centers where most cancer treatments are delivered. NRG NCORP will conduct high impact studies for patients with many types of solid tumors with a particular unique focus in both women's health and cancer control issues related to radiation therapy. To accomplish these aims NRG NCORP will engage fully with community physicians and patient advocates as well as the NCI and NCI- designated cancer centers to collaborate to improve cancer prevention and control, cancer care and outcomes, and quality of life for patients affected by cancer.

PI_NAMEs: BRUNER, DEBORAH WATKINS (contact);KACHNIC, LISA A.

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Address;Adjuvant Therapy;Advocate;Affect;Aftercare;Area;base;Behavior assessment;Behavior Therapy;biomarker evaluation;cancer care;Cancer Center;Cancer Control;Cancer Control Research;cancer diagnosis;cancer health disparity;cancer prevention;cancer risk;cancer therapy;care delivery;care outcomes;Caring;Clinical;clinical imaging;Clinical Oncology;clinical practice;Clinical Research Associate;Clinical Trials;Clinical Trials Design;cluster randomized design;Collaborations;Collection;Communities;community center;Community Clinical Oncology Program;Community Physician;Concept Review;Correlative Study;cost effectiveness;Credentialing;Data;Data Analyses;Data Collection;Data Coordinating Center;data integrity;data management;design;Development;Disease;disorder risk;Disparity;effectiveness testing;Elderly;Ensure;ethnic minority;evidence base;Evidence based intervention;experience;Exposure to;Family;Funding;Gender;Genetic;Goals;Grant;Gynecologic Oncology Group;Health Disparities Research;health disparity;Health Services Accessibility;Hospice Care;Image;Immunotherapy;improved;Information Technology;Infrastructure;innovation;Institution;Intervention;Intervention Trial;Leadership;Localized Malignant Neoplasm;Lymphedema;Malignant Neoplasms;member;Mentorship;Methodology;Minority;Modality;Modification;Molecular;Monitor;multidisciplinary;National Cancer Institute;National Clinical Trials Network;National Surgical Adjuvant Breast and Bowel Project;Neurocognitive;next generation;Oncology;oncology program;Outcome;Outcomes Research;Palliative Care;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Phase;Primary Care;Principal Investigator;programs;quality assurance;Quality Control;Quality of life;racial minority;Radiation Oncology;Radiation therapy;Radiation Therapy Oncology Group;Reporting;Research;Research Personnel;Resources;Risk Reduction;Rural Population;screening;Security;Series;Sex Functioning;Site;Solid Neoplasm;Southwest Oncology Group;Survivors;survivorship;symptom management;Symptoms;Testing;Therapeutic Clinical Trial;therapeutic evaluation;Therapeutic Trials;therapy design;Toxic effect;Training;Training Activity;Training and Education;Training Programs;Translational Research;treatment trial;Treatment-Related Cancer;trial design;underserved community;Woman;Women's Health;Work

PROJECT_TITLE: NRG Oncology NCORP Research Base


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: DAVIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative. How mammalian peripheral sensory neurons encode cold remains poorly defined, despite the essential nature of cold detection to human survival and the prevalence of cold hypersensitivity in several pain etiologies. The goal of this proposal is to systematically and unequivocally define a new role for the voltage- gated sodium channel, NaV1.1, in physiological cold sensing and cold allodynia using approaches that span ion channel biophysics and mouse behavior. Results from this study will deepen our basic understanding of thermal- sensing mechanisms and how they are highjacked during pain.

PI_NAMEs: GRIFFITH, THEANNE NICOLE (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Action Potentials;Address;Advisory Committees;Affect;Afferent Neurons;allodynia;Attenuated;avoidance behavior;Award;Behavior;behavior test;Behavioral Assay;Biometry;biophysical properties;Biophysics;Brain;career;career development;Central Nervous System;chronic constriction injury;Closure by clamp;cold temperature;Communication;conditional knockout;Data;Detection;Development;Development Plans;Disease;Electrophysiology (science);Ensure;Environment;Esthesia;Etiology;experience;Experimental Designs;experimental study;Genetic;Goals;Health;Human;human disease;Hyperalgesia;Hypersensitivity;In Situ Hybridization;In Vitro;in vivo;Individual;innovation;insight;Institution;Ion Channel;Knockout Mice;Knowledge;Laboratories;Learning;Mammals;mechanical allodynia;Mediator;Mentors;Mentorship;Molecular;mouse model;Mus;mutant;natural hypothermia;Nature;nerve injury;Nervous System;Nervous System Physiology;Neurons;Neurosciences;neurotransmission;new therapeutic target;novel;Oral;oxaliplatin;Pain;pain model;painful neuropathy;Painless;patch clamp;Pathway interactions;Peripheral;peripheral nerve damage;Peripheral Nervous System;Peripheral Nervous System Diseases;pharmacologic;Physiological;Play;Positioning Attribute;pre-clinical;preference;Prevalence;programs;Protein Isoforms;receptor;Research;Role;SCN1A protein;Signal Pathway;Signal Transduction;skills;skin damage;Sodium Channel;somatosensory;Spinal Ganglia;Statistical Data Interpretation;Stimulus;Temperature;Testing;tool;Training;transcriptome sequencing;Transgenic Mice;Translations;transmission process;Trigeminal System;voltage;warm temperature;Work;Writing

PROJECT_TITLE: A Novel Role for Nav1.1 in Mammalian Thermosensation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Dissemination and Implementation Research;Mental Health;Mental Illness;Neurodegenerative;Palliative Care;Prevention;Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative: Distress (e.g., depression and anxiety symptoms) in older adults with cancer and mild cognitive impairment (MCI) represent a significant public health burden for them and their caregivers in terms of impaired quality of life, that impact their coping abilities and communication (e.g., future health care planning). The COPE+ intervention is a promising mental health and communication treatment for older adults with cancer and MCI, and their caregivers. The proposed study will conduct a pilot study to test a brief (6-week), tablet- based, personalized intervention that includes family caregivers, in this at-risk group.

PI_NAMEs: RAMOS, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Affect;Anxiety;anxiety symptoms;Area;arm;Award;Behavior Therapy;Behavioral Model;Behavioral Sciences;Biometry;Cancer Burden;cancer care;cancer diagnosis;cancer therapy;career development;Caregivers;Caring;chemobrain;Client satisfaction;clinical practice;Cognitive deficits;Cognitive Therapy;Communication;Communication Programs;Communities;comorbidity;Complex;coping;Coping Skills;Coupled;Data;Data Collection;depressive symptoms;design;Development;Diagnosis;Dissemination and Implementation;Distress;Division of Cancer Control and Population Sciences;Educational process of instructing;Elderly;Elements;evaluation/testing;experience;Face;Family;Family Caregiver;Feedback;follow-up;formative assessment;Frequencies;Future;Geriatric Psychiatry;Geriatrics;Goals;Health Personnel;Health Psychology;Health Services;Healthcare;human old age (65+);Impairment;implementation science;improved;Individual;innovation;interest;International;Intervention;intervention refinement;Interview;Judgment;K-Series Research Career Programs;Knowledge;Length;Life;Life Experience;Literature;loved ones;Malignant Neoplasms;Manuals;Measures;Mediation;Medical;Memory;Mental Depression;Mental Health;Mentors;Mentorship;mild cognitive impairment;Minority;Mission;Modification;novel;older adult;Older Population;Oncology;Outcome;Palliative Care;Participant;participant interview;Patients;Personal Satisfaction;personalized intervention;Persons;Pilot Projects;pilot test;Population;Populations at Risk;Positioning Attribute;primary outcome;Procedures;Program Development;programs;Provider;psychological distress;psychological outcomes;psychosocial;Public Health;Qualitative Research;Quality of life;recruit;Reporting;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;Risk;satisfaction;Scientific Advances and Accomplishments;secondary outcome;Secure;Self Management;Signal Transduction;skills;skills training;Structure;Symptoms;Tablets;Teacher Professional Development;Testing;theories;therapy design;therapy development;Thinking;Training;United States National Institutes of Health;videoconference;Work

PROJECT_TITLE: A Patient-Caregiver Behavioral Intervention for Older Adults with Cancer and Mild Cognitive Impairment

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Duchenne/ Becker Muscular Dystrophy;Human Fetal Tissue;Muscular Dystrophy;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This proposal aims to understand and interrogate the differences in skeletal muscle progenitor cells (SMPCs) compared to adult satellite cells (SCs) both molecularly and functionally to enable generation of more regenerative cells from human pluripotent stem cells (hPSCs). Generation of the most regenerative SMPC or SC-like cells from hPSCs could improve our ability to model muscle diseases in a dish and have the potential for use in personalized cell replacement therapies.

PI_NAMEs: PYLE, APRIL D (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 3-Dimensional;Adult;adult stem cell;Bar Codes;candidate identification;Cell Line;Cell Maturation;cell replacement therapy;Cell Therapy;Cells;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;Data Set;Development;differentiation in vitro;directed differentiation;Disease;disease model;disease-in-a-dish;Duchenne muscular dystrophy;Embryo;Engineering;Engraftment;Enhancers;Environment;exhaustion;fetal;Fetal Skeleton;Fiber;Functional disorder;functional improvement;Funding;Generations;Genes;Genome;Grant;Human;human adult stem cell;Human Development;human pluripotent stem cell;Immunocompromised Host;improved;In Vitro;in vivo;indexing;Injury;insight;Knowledge;mdx mouse;Modeling;Molecular;Monitor;mouse model;Mus;muscle degeneration;Muscle Development;Muscle Fibers;muscle progenitor cell;muscle regeneration;Muscle satellite cell;Muscular Dystrophies;myogenesis;Myopathy;Natural regeneration;Nature;novel;overexpression;PAX7 gene;Phase;Population;postnatal;programs;Protocols documentation;Publications;regenerative;regenerative cell;Regenerative Medicine;Regulation;Reporter;Severity of illness;single cell sequencing;Skeletal Muscle;stem cell biology;stem cell niche;stem cells;stemness;therapeutic candidate;Time;tool;Work

PROJECT_TITLE: Reprogramming and Directed Differentiation of Skeletal Muscle Cells from hPSCs


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence

PHR: PROJECT NARRATIVE We previously showed that the mechanical properties of tissues are an emergent property, arising only from the when the components of the tissue (cells and the extracellular matrix) are combined. The overall goal of this competing renewal proposal is to expand our understanding of complex tissue mechanics to specifically include viscosity, to define how cells, the matrix, and forces acting on tissues combine to determine tissue mechanics, and to determine the impact of these mechanics on cell behavior. The model tissue in this proposal, as in previous project periods, is the normal, fibrotic, and cirrhotic liver.

PI_NAMEs: JANMEY, PAUL A;SHENOY, VIVEK ;WELLS, REBECCA G (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: algorithm training;Artificial tissue;Behavior;cell behavior;Cells;Cirrhosis;clinically relevant;Complex;Cytoplasmic Inclusion;Cytoskeleton;Data;defined contribution;design;Development;Disease;Elastic Tissue;Elasticity;Elements;Extracellular Matrix;Fibrosis;Goals;Health;Histology;In Vitro;in vivo;Individual;Intercellular Fluid;Intervention;Length;Link;Liver;Machine Learning;machine learning method;Measurement;Measures;mechanical properties;Mechanical Stress;Mechanics;Metabolism;Modeling;Multiscale Mechanics;Organ;Pathologic;Perfusion;prediction algorithm;Predictive Value;pressure;Property;Role;Solid;Stress;Structure;System;Testing;theories;Therapeutically Targetable;Time;Tissue Model;Tissues;viscoelasticity;Viscosity;Work

PROJECT_TITLE: Pathological consequences of altered tissue mechanics in fibrosis

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Prevention;Rural Health

ORG_CITY: DANVILLE

ORG_NAME: GEISINGER CLINIC

PHR: Project Narrative The Geisinger Cancer Institute NCI Community Oncology Research Program (Geisinger Cancer Institute NCORP) builds upon a strong foundation of cancer research from our rich experience with National Cancer Institute (NCI) collaborations. The goals of the Geisinger Cancer Institute NCORP are to work in partnership with the NCI NCORP network to bring cancer clinical trials (cancer control, prevention, screening, treatment, and imaging), as well as cancer care delivery research, to individuals in their own communities, thus generating a broadly applicable evidence base that contributes to improved patient outcomes and a reduction in cancer disparities.

PI_NAMEs: PANIKKAR, RAJIV  (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Advanced Malignant Neoplasm;Aftercare;anti-cancer research;Area;base;cancer care;cancer clinical trial;Cancer Control;cancer health disparity;cancer prevention;Cancer Research Network;care delivery;care outcomes;clinical imaging;Clinical Oncology;Clinical Research;Clinical Trials;Collaborations;Communities;Community Clinical Oncology Program;Conduct Clinical Trials;Engineering;Environment;Ethnic Origin;evidence base;experience;Foundations;Goals;health information technology;Health Service Area;Healthcare;Home;Image;improved;Individual;Information Technology;Infrastructure;Integrated Delivery Systems;Leadership;Location;Malignant Neoplasms;medically underserved;Mission;National Cancer Institute;Oncology Group;Participant;patient population;Patient-Focused Outcomes;Patients;Physicians;Policies;population health;Population Heterogeneity;Prevention;Process;programs;Race;recruit;Research;Research Institute;Research Personnel;rural underserved;screening;Site;Structure;success;System;Trust;Work

PROJECT_TITLE: Geisinger Cancer Institute - NCI Community Oncology Research Program (NCORP)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Nutrition

PHR: NARRATIVE Claudin channels define paracellular flux of ions and small molecules across the tight junction, and their dysregulation can contribute to many intestinal diseases, including inflammatory bowel disease. We will use in silico, in vitro, ex vivo, and in vivo models and first-in-class claudin cation channel blockers to study mechanisms of claudin-2 and -15 controlled cation flux. We anticipate that our findings will provide insight into mechanisms of nutrient transport and diarrhea in the gastrointestinal tract and potentially lead to novel drugs to benefit human health.

PI_NAMEs: KHALILI-ARAGHI, FATEMEH ;WEBER, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Address;Affect;Affinity;Amino Acids;Biophysics;Biopsy;Cations;CD4 Positive T Lymphocytes;Celiac Disease;channel blockers;Charge;Colitis;Computer Models;Coupled;Defect;design;Development;Diarrhea;Disease;Elements;Epithelial Cells;Epithelium;Family;Functional disorder;Gastrointestinal tract structure;Genetic;Glucose;Goals;Health;Human;human tissue;Immune;improved;in silico;In Vitro;in vivo Model;Individual;Infectious colitis;Inflammation;Inflammatory Bowel Diseases;innovation;insight;Interleukin-13;Intestinal Absorption;Intestinal Diseases;intestinal epithelium;Intestinal Mucosa;Intestinal permeability;Intestines;Ion Channel;Ion Transport;Ions;Knowledge;Malabsorption Syndromes;Measurement;Mediating;Membrane;Modeling;Molecular;molecular dynamics;monolayer;Monovalent Cations;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;murine colitis;Mus;mutant;novel;novel therapeutic intervention;novel therapeutics;Nutrient;nutrient absorption;patch clamp;Patch-Clamp Techniques;Pathway interactions;Patients;Permeability;Pharmacological Treatment;Physiological;Physiology;prevent;Process;Property;Proteins;Regulation;Research;Resolution;Role;seal;Series;small molecule;small molecule inhibitor;Sodium;Structure;Structure-Activity Relationship;T cell therapy;Tight Junctions;tool;Transmembrane Domain

PROJECT_TITLE: Structure, function, and modulation of claudin cation channels in the GI tract

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Pain Research;Rare Diseases;Wound Healing and Care

ORG_CITY: PORTLAND

ORG_DEPT: DERMATOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Pyoderma gangrenosum (PG) is an inflammatory skin condition that causes chronic ulcers and profoundly affects quality of life and mortality. PG is the prototypical misdiagnosed wound which can lead to mismanagement such as unnecessary treatment with intravenous antibiotics or unneeded surgical procedures (including limb amputations). The aims of this project are to determine the best diagnostic approach for PG, and to unravel real- world treatment outcomes for current therapeutic approaches, redefining the therapeutic landscape of this disease.

PI_NAMEs: ORTEGA LOAYZA, ALEX  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: accurate diagnosis;Address;Adopted;Adoption;Adrenal Cortex Hormones;Adult;Affect;Agreement;Alternative Therapies;Antibiotics;Biological Products;Chronic;chronic infection;chronic ulcer;Clinical;clinical care;clinical practice;Clinical Research;Clinical Trials;cohort;Collaborations;Comparison arm;Consensus;Country;Cyclosporine;Data;design;Development;Diagnosis;Diagnostic;diagnostic strategy;Disease;effectiveness evaluation;Enrollment;Ensure;evidence based guidelines;Expert Opinion;FDA approved;Future;future implementation;Goals;Guidelines;healing;Health;Health Care Costs;healthcare burden;Heart Diseases;Immunosuppression;Immunosuppressive Agents;improved;inclusion criteria;Inflammatory;inhibitor;innovation;Inpatients;Institution;International;Intravenous;Knowledge;Lead;limb amputation;Medical;middle age;molecular diagnostics;mortality;mortality risk;novel therapeutics;Operative Surgical Procedures;Oregon;Outcome;Pain;Pain management;Patients;Performance;Pharmaceutical Preparations;Practice Management;Process;prospective;Prospective Studies;Protocols documentation;Psychological Impact;Pyoderma Gangrenosum;Quality of life;Reporting;Research;Research Design;Research Personnel;Retrospective Studies;Safety;Science;Scientist;Signal Transduction;Skin;skin ulcer;standard of care;Standardization;success;Therapeutic;TNF gene;treatment comparison;Treatment outcome;United States;Universities;unnecessary treatment;Variant;wound;wound care

PROJECT_TITLE: Diagnostic and treatment landscape of pyoderma gangrenosum

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Services;Mental Health

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Physical frailty and cognitive impairment are prevalent age-related conditions that often co-occur and are strongly correlated with depression in older adults. Studies on the burden and development of these two conditions in nursing home residents are limited, and the findings on the underlying mechanisms between physical frailty and cognitive impairment and the role of depression and antidepressants on their progression are inconsistent. In the dissertation phase of this project, the candidate will characterize the prevalence, heterogeneous clinical presentation, and trajectories of physical frailty and cognitive impairment in older U.S. nursing home residents; for the post-doctoral phase, the candidate will elucidate the relationship between physical frailty and cognitive impairment as well as explore the impact of depressive symptoms and antidepressants in the development of both conditions in U.S. community-dwelling older adults.

PI_NAMEs: YUAN, YIYANG  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acceleration;Address;Adult;Adverse effects;Affect;age related;Aging;aging population;aging process;anti-depressive agents;Caregiver Burden;Caring;Clinical;Cognitive;cognitive testing;Communities;Complex;Data;Data Set;Databases;Dementia;depressive symptoms;design;Development;diagnostic tool;disability;Elderly;Equation;Event;Exposure to;Fostering;Foundations;frailty;functional decline;functional independence;Future;Goals;Health;Health and Retirement Study;Health Care Costs;Heterogeneity;human old age (65+);Impaired cognition;Impairment;improved;innovation;insight;Knowledge;Link;Long-Term Care;Longevity;Measures;Mediation;Mediator;Medicare;Mental Depression;Methodology;Methods;mild cognitive impairment;Modeling;National Institute on Aging;neglect;Neurologic;neuropathology;nursing home length of stay;Nursing Homes;older adult;Outcome;Pathway interactions;Personal Satisfaction;Pharmaceutical Preparations;Phase;Physiological;Population;Postdoctoral Fellow;predictive modeling;Prevalence;Protocols documentation;Psychosocial Factor;Quality of life;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;risk prediction;risk sharing;Role;Sampling;Statistical Methods;stressor;Subgroup;Techniques;Time;Training;Variant;Work

PROJECT_TITLE: Concurrent trajectories of physical frailty and cognitive impairment among nursing home residents and community-dwelling older adults


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Cancer;Liver Disease;Nutrition;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The overall purpose of this project is to understand the mechanism by which the cholecystokinin (CCK) B- receptor is activated in liver injury and NASH and how this activation increases the risk for hepatocellular cancer (HCC). Epigenetic regulation of the CCK receptor will be studied and cross-talk with chemokine receptors. Several murine models of liver injury and a transgenic CCK-BR-knockout mouse model will be used to investigate whether stem cells or liver progenitor cells express the CCK-BR and if a CCK-receptor antagonist can decrease the risk of HCC.

PI_NAMEs: GAY, MARTHA  (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Address;antagonist;Applications Grants;Biochemical;Biology;Body Weight decreased;Budgets;cancer cell;cancer risk;carcinogenesis;career;career development;CCKBR gene;Cells;chemokine receptor;Cholecystokinin;Cholecystokinin B Receptor;Cholecystokinin Receptor;Choline Deficiency;Cirrhosis;Collagen;CRISPR/Cas technology;cytokine;Development;Development Plans;Diet;dietary;Dietary Fats;effective therapy;Engineering;Epidemic;Epigenetic Process;epigenetic regulation;epigenomics;Ethionine;experience;Fibroblasts;Fibrosis;Functional disorder;G-Protein-Coupled Receptors;Gastrins;gastrointestinal;Gastrointestinal tract structure;Goals;graduate student;Growth;Hepatic;Hepatic Stellate Cell;Hepatocarcinogenesis;Hepatology;Histologic;Histology;Human;human tissue;Immunologist;Immunology;In Vitro;in vitro testing;in vivo;Inflammation;Inflammatory;innovation;Knock-out;Knockout Mice;Ligands;Liver;Liver Fibrosis;liver inflammation;liver injury;Liver Stem Cell;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of liver;Malignant Neoplasms;Manuscripts;Mediating;Mediator;Mentors;Methodology;MicroRNAs;Modeling;mouse model;Mus;Neoplasm Metastasis;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;nutrition;Organoids;overexpression;Pathway interactions;Patients;Penetration;Peptic Ulcer;Pharmaceutical Preparations;Physiological;Preparation;prevent;Prevention;Primary carcinoma of the liver cells;Proglumide;Proliferating;protein expression;Proteins;Publications;receptor;Receptor Activation;receptor expression;Research;Research Personnel;response;Risk;RNA;Role;saturated fat;Scientist;stellate cell;stem cell population;stem cells;subcutaneous;symposium;System;Testing;Therapeutic Agents;timeline;Tissue Microarray;Tissues;Training;transcriptome;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;tumor;tumor growth;undergraduate student;United States;Vitamin E;Work

PROJECT_TITLE: Role of cholecystokinin receptor in hepatocellular cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Palliative Care;Patient Safety;Prevention

PHR: PROJECT NARRATIVE The overall mission of the SWOG National Cancer Institute Community Oncology Research Program Research Base is to rapidly design, activate and complete biologically-driven, scientifically important, and clinically meaningful studies in cancer prevention, control and cancer care delivery in adults, adolescents and young adults with or at risk for cancer, and to improve quality of life and quality of survivorship for those with malignancies.

PI_NAMEs: BLANKE, CHARLES D. (contact);HERSHMAN, DAWN ;TANGEN, CATHERINE M.

PROJECT_TERMS: academic program;Address;Administrative Efficiency;Adolescent;Adolescent and Young Adult;Adult;Advisory Committees;Advocate;base;Basic Science;Benefits and Risks;Biometry;Cancer Burden;cancer care;Cancer Center;Cancer Control;Cancer Control Research Program;cancer prevention;Cancer Research Network;cancer risk;care delivery;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Collection;Communication;Communities;Community Clinical Oncology Program;community engagement;community research;Comparative Study;Complement;Complex;Data;data infrastructure;data management;Data Reporting;design;Development;disparity reduction;Dissemination and Implementation;Education;Electronic Health Record;Enrollment;Ensure;Environment;Equity;Evidence based practice;expectation;experience;Faculty;Fostering;Foundations;Funding;Future;global health;Goals;Grant;Guidelines;health care disparity;image translation;imaging biomarker;improved;Information Dissemination;innovation;Institution;International;Intervention;Intervention Studies;Journals;Lead;Leadership;Malignant Neoplasms;Manuscripts;Medical;meetings;member;Mentors;Metadata;Minority;Mission;Modernization;multidisciplinary;National Cancer Institute;Natural Language Processing;novel;Observational Study;Oncologist;operation;organizational structure;Pathway interactions;Patient Outcomes Assessments;Patients;Policies;Population;Population Sciences;Prevention;Productivity;programs;Publishing;Quality of life;quality of life for cancer survivors;Reporting;Reproducibility;Research;Research Personnel;Resources;Retrieval;Safety;Secure;Site;social media;software systems;Southwest Oncology Group;Speed;Standardization;Statistical Data Interpretation;Structure;student training;survivorship;symptom management;System;Teacher Professional Development;telehealth;tool;Training;translational medicine;Translational trial;treatment risk;trial design;uptake;virtual;Voice;Work;young adult

PROJECT_TITLE: SWOG NCORP Research Base


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness;Sleep Research

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: PROJECT NARRATIVE Outcomes in schizophrenia (SZ) may improve significantly with early intervention as opposed to reversal of morbidity, however, all currently available antipsychotics are effective on similar pathways, treatment failure or partial response is common. Therefore, there is a critical need to identify new biological processes that contribute to the pathology early in the illness. Proposed studies aim to identify a specific bioenergetic abnormality in early SZ and establish a mechanism that can be targeted for the treatment of this abnormality.

PI_NAMEs: YUKSEL, ABDULLAH CAGRI (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Antipsychotic Agents;Biochemical;Bioenergetics;Biological;Biological Process;Bipolar Disorder;Brain;brain abnormalities;Brain region;career development;Cell Respiration;Cells;Cellular biology;Characteristics;Chronic Schizophrenia;Consumption;Coupled;Creatine Kinase;Data;density;Development Plans;Disease;Early Intervention;Electroencephalography;Energy Metabolism;Energy-Generating Resources;Enzymes;experimental study;first episode psychosis;Frequencies;frontal lobe;functional decline;Funding;Glucose;Glutamates;Goals;Grant;Homeostasis;Impaired cognition;Impairment;improved;in vivo;information processing;inorganic phosphate;Intermediate Variables;Intervention;Laboratories;Link;Measures;Mediating;Mediator;Mentorship;Metabolic;Metabolism;Mitochondria;Modality;Molecular;Morbidity - disease rate;Natural regeneration;neuroimaging;Neurons;neurotransmission;non rapid eye movement;non-affective psychoses;novel;novel strategies;Occipital lobe;Organ;Outcome;Oxidative Phosphorylation;Oxygen;partial response;Pathology;Pathway interactions;patient variability;Patients;Pharmaceutical Preparations;Phosphorus;Photic Stimulation;Play;Polysomnography;preservation;Process;Psychiatrist;psychotic;Psychotic Disorders;Qualifying;Reaction;Research;Research Personnel;response;Rest;Role;Schizophrenia;severe psychiatric disorder;side effect;skills;Sleep;sleep abnormalities;Sleep Deprivation;Sleep disturbances;Sleeplessness;Slow-Wave Sleep;statistics;Structure;Synapses;targeted treatment;Techniques;Testing;Time;Training;Treatment Failure;Writing

PROJECT_TITLE: Brain bioenergetics and slow wave activity in first episode psychosis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Rare Diseases;Vaccine Related

PHR: PROJECT NARRATIVE Public health departments increasingly use predictive models to make decisions on the best policies to reduce infectious diseases in the United States. Yet there is limited evidence on how these predictive models are used by public health departments and whether their use translates into policies that reduce infectious diseases. The proposed research aims to develop predictive modeling tools for California public health departments to allocate targeted vaccines to their highest-risk populations, and then study the implementation and public health impact of using these predictive tools to guide real-time vaccination policy.

PI_NAMEs: LO, NATHAN  (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: Address;Age;Age Factors;California;Collaborations;Communicable Diseases;Communication;comparative effectiveness;cost;County;COVID-19 pandemic;Data;Data Sources;Decision Making;Demographic Factors;design;Disease;Disease Outbreaks;epidemiologic data;Epidemiology;Equilibrium;Evaluation;Evolution;experience;experimental study;Feasibility Studies;Foundations;Future;Goals;Hepatitis A;Heterogeneity;high risk;high risk population;implementation measures;implementation outcomes;implementation science;improved;Individual;Infection;infection risk;Influenza A virus;innovation;insight;Intervention;Interview;Investigation;Location;mathematical model;Measures;Methods;model development;Modeling;novel;Online Systems;open source;Outcome;Pertussis;Pilot Projects;Policies;Population;post-doctoral training;predictive modeling;predictive tools;Public Health;Public Health Practice;Public Policy;Randomized;randomized trial;Recommendation;Research;Resource Allocation;Resources;Risk Factors;routine practice;seasonal influenza;Seasons;Standardization;surveillance data;Surveys;Testing;Time;tool;Translating;United States;uptake;usability;Vaccination;vaccination strategy;Vaccines;Validation;web-based tool;Work

PROJECT_TITLE: Real-time predictive modeling for public health departments to control infectious diseases


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Endocannabinoid System Research;Nutrition;Obesity;Prevention;Sleep Research

PHR: Narrative Obesity and diabetes have reached epidemic proportions in modern society, with great costs to health care systems. This proposal will uncover the influence of chronic sleep restriction and circadian disruption, both independently and in combination, on metabolic health. The findings from this project will inform the development of biological and behavioral interventions to promote healthy weight in not only overweight or obese individuals, but also individuals at risk for obesity who live on restricted sleep schedules and/or work on extended duration, rotating, or permanent night shifts.

PI_NAMEs: MCHILL, ANDREW WILLIAM (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Accounting;Acute;American;Area;Automobile Driving;Behavior Therapy;Biological;biological development;Biology;Calories;Carbohydrates;cardiometabolic risk;cardiometabolism;Chronic;circadian;circadian biology;Circadian desynchrony;Circadian Dysregulation;clinical translation;comorbidity;Confounding Factors (Epidemiology);Consumption;Control Groups;cost;Data;design;Desire for food;Diabetes Mellitus;Diet;Disease;Eating;Endocannabinoids;endogenous cannabinoid system;energy balance;Energy Intake;Energy Metabolism;Epidemic;FAT gene;Fatty acid glycerol esters;Food;Food Access;food quality;glucose tolerance;Goals;Grapes;Health;Health Care Costs;Healthcare Systems;healthy weight;hedonic;Hormones;Human;Hunger;Ice Cream;impaired glucose tolerance;Impaired health;Impairment;improved;Individual;insulin sensitivity;Intake;Intervention;Laboratories;Measures;Metabolic;Metabolism;Modernization;mortality;obese person;Obesity;obesity risk;Outcome;Overweight;Participant;Pathway interactions;Pattern;Phase;Process;Protocols documentation;Randomized;randomized, controlled study;Research;Research Priority;Risk;Rotation;Schedule;shift work;Sleep;Sleep Deprivation;Sleep Disorders;sleep health;sleep onset;Societies;System;Testing;therapy development;Time;translational study;United States;United States National Institutes of Health;Wakefulness;Weight Gain;Work;Yogurt

PROJECT_TITLE: Uncovering sleep and circadian mechanisms contributing to adverse metabolic health

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE We propose to create a state-of-the-art Dietary Biomarker Development Center at Harvard University to systematically catalog validated metabolomic signatures of important food sources of protein and carbohydrates in the US diets. This will be accomplished by combining cutting-edge metabolomics technologies with controlled feeding studies and well-established observational cohorts for the discovery and validations of novel biomarkers of food intake. The findings will contribute to the accelerated discovery of objective and robust dietary biomarkers, thereby facilitating precision nutrition research to improve human health.

PI_NAMEs: CLISH, CLARY B;HU, FRANK B (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Acceleration;Acute;analytical tool;Area;Avena sativa;beef;Biological Markers;biomarker development;biomarker discovery;biomarker identification;Biomarker of Dietary Intake;biomarker performance;biomarker validation;Biomedical Research;Bread;Calibration;Carbohydrates;Catalogs;chemical property;Chickens;cohort;Cohort Studies;Collaborations;Computer software;Crossover Design;Data;Data Analyses;Data Coordinating Center;data sharing;data submission;Dedications;Diet;dietary;Dietary Assessment;Dietary intake;Dietary Practices;Dose;Drug Kinetics;Eating;Ensure;Environment;experience;Faculty;feeding;Follow-Up Studies;Food;food consumption;Food Selections;Fostering;Goals;gut microbiome;Health;Health Professional;Hispanic;Hospitals;Hour;Human;Human Characteristics;Human Microbiome;improved;indexing;Individual;innovation;Institution;Intake;Intervention;large datasets;Leadership;Life Style;liquid chromatography mass spectrometry;Measurement;Measures;medical schools;metabolome;metabolomics;Methodology;Methods;Molecular;multidisciplinary;Multiomic Data;novel;novel marker;Nurses' Health Study;Nutrient;nutrition;Nutritional Study;Participant;Physical activity;physical property;Plasma;Population;Potato;precision nutrition;Productivity;programs;Proteins;Public Health Schools;Qualifying;Randomized;Recording of previous events;Research Personnel;Resolution;Resource Sharing;Resources;response;Source;Soybeans;Structure;Study of Latinos;Technology;Testing;tool;Training;Trans-Omics for Precision Medicine;Transducers;United States Department of Agriculture;United States National Institutes of Health;Universities;Urine;Validation;validation studies;Wheat;Woman

PROJECT_TITLE: Dietary Biomarkers Development Center at Harvard University


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Hematology;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: JACKSON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: PROJECT NARRATIVE Preeclampsia, classically defined as new-onset hypertension and proteinuria after 20 weeks of gestation, affects 3-5% of all pregnancies worldwide, carrying devastating health consequences for both mother and offspring. While it has been found that (1) placental and circulating levels of cell-free mitochondrial DNA (mtDNA) are elevated in preeclampsia and (2) DNase I inhibits mtDNA-mediated platelet activation and thrombus formation in other disease processes, the effects of DNase I on the hypercoagulable state characterizing preeclampsia are unknown. The potential therapeutic application of DNase I to modulate hypercoagulability and associated thrombosis in the placental and systemic circulation would constitute a major paradigm shift in treatment of preeclampsia.

PI_NAMEs: PALEI, ANA CAROLINA (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Address;Affect;Angiogenesis Inhibitors;Angiogenic Factor;Animals;Anticoagulants;Apoptosis;Automobile Driving;Blood Platelets;Brain Hypoxia-Ischemia;Cell secretion;Cells;Chronic;Circulation;Clinical;clinically relevant;clinically significant;Consumption;Cytolysis;Data;Deoxyribonuclease I;Disease;effective therapy;Endoglin;Enzymes;Etiology;Event;Exhibits;experience;Experimental Models;extracellular;Fetal Growth Retardation;Fibrinolytic Agents;Health;Hemodilution;Hypertension;Hypoxia;improved;In Vitro;in vivo;Infusion procedures;injured;Injury;Knowledge;Lead;maternal morbidity;Maternal Mortality;maternal risk;Mediating;Mediator;Mentors;Methodology;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Swelling;Modeling;Molecular;Mothers;novel;novel strategies;novel therapeutics;offspring;Organ;particle;Pathology;Pathway interactions;Patients;Pattern;perinatal morbidity;Perinatal mortality demographics;Placenta;Placenta Diseases;Platelet Activation;Platelet aggregation;Platelet Aggregation Inhibitors;Platelet Count measurement;post pregnancy;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnant;Premature Birth;Process;Production;Proteinuria;Public Health;Rattus;Reactive Oxygen Species;Research Personnel;Research Project Grants;response;Risk;Role;Site;standard of care;Symptoms;Syncytiotrophoblast;System;Testing;Therapeutic;Thrombophilia;Thrombosis;thrombotic;Thrombus;Tissues;training project;Vascular Diseases;Vascular Endothelial Growth Factor Receptor-1;Vesicle;Villous

PROJECT_TITLE: Platelet-mediated mechanisms of placental and systemic hypercoagulability in preeclampsia


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Prevention

PI_NAMEs: HU, FRANK B (contact)

PROJECT_TERMS: Achievement;American diet;Area;Bioinformatics;bioinformatics tool;Biological Assay;Biological Markers;biomarker development;biomarker validation;Biotechnology;Budgets;Carbohydrates;catalyst;Collection;Committee Members;Communication;Communities;Data;Data Analyses;Data Coordinating Center;data sharing;data submission;Databases;Development;Diet;dietary;Dietary Assessment;Dietary intake;Dietary Intervention;doubly-labeled water;Eating;Energy Intake;Ensure;Environment;Evaluation;Expenditure;feeding;Follow-Up Studies;Food;Goals;graduate student;Health Professional;Hour;human subject;improved;Individual;Infrastructure;innovation;Institution;Institutional Review Boards;Intake;Interdisciplinary Study;Intervention;Intervention Trial;Lead;Leadership;Measurement;Measures;Medical;meetings;metabolomics;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nitrogen;novel;novel marker;Nurses' Health Study;Nutrient;nutrition;Nutritional Biochemistry;Nutritional Study;Obesity;Observational Study;Patient Recruitments;Patient Self-Report;Play;Population Sciences;Postdoctoral Fellow;Potassium;programs;Progress Reports;Prospective, cohort study;protein intake;Proteins;Public Health Schools;Quality Control;randomized, clinical trials;Recovery;Research;Research Design;Research Personnel;Resources;Role;Schedule;Science;Source;Techniques;Technology;training opportunity;Travel;United States Department of Agriculture;United States National Institutes of Health;Universities;Update;urinary;web site;Work

PROJECT_TITLE: Administrative Core for the Dietary Biomarkers Development Center at Harvard University


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative: This study aims to identify and characterize genetic loci underlying coronary artery disease in populations of African ancestry. We will efficiently leverage the existing resources of the Population Architecture using Genomics and Epidemiology Consortium, Million Veteran Program and other established cohorts to create the largest-ever sample size for a study of an African-ancestry population comprehensively phenotyped for CAD and related cardiometabolic traits. The outcome of this study will provide a better understanding of the genetics of CAD and its risk factors in this high-risk population and has a strong likelihood of leading to measures that can help with the control and prevention of CAD in populations of African ancestry.

PI_NAMEs: LU, YINGCHANG  (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Address;Admixture;admixture mapping;Adult;African American;African American population;African ancestry;Architecture;Asian ancestry;Awareness;biobank;Biological;blood lipid;Blood Pressure;Body mass index;cardiometabolism;Cause of Death;Chromatin;Classification;Clinical;clinical application;clinical translation;clinically relevant;Cluster Analysis;cohort;Complement;Coronary Arteriosclerosis;Data;Data Set;Development;Diabetes Mellitus;Diagnosis;disease disparity;disorder risk;East Asian;Electronic Health Record;Epidemiology;Ethnic Origin;European;European ancestry;Evaluation;experience;Family history of;Fasting;fasting glucose;Frequencies;Functional disorder;Gene Frequency;Genes;Genetic;genetic architecture;genetic information;Genetic study;genetic variant;Genome;genome wide association study;genome-wide;genomic locus;Genomics;Glycosylated hemoglobin A;high risk population;implementation facilitation;improved;in silico;In Vitro;Individual;insight;Insulin;inter-individual variation;Joints;Linkage Disequilibrium;Maps;Measures;Mendelian disorder;Meta-Analysis;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Outcome Study;Pathogenicity;Pathway Analysis;phenome;Phenotype;Physiological;polygenic risk score;Population;Population Heterogeneity;precision medicine;Prevalence;Prevention;programs;Public Health;rare variant;Resources;Risk;Risk Factors;risk sharing;risk variant;Sample Size;Statistical Methods;Structure;Syndrome;Testing;Tissues;trait;translational genetics;United States;Variant;Veterans;Vulnerable Populations;Waist-Hip Ratio;Work

PROJECT_TITLE: Genome-wide association study of coronary artery disease in individuals of African ancestry

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Prevention

ORG_CITY: BOSTON

PI_NAMEs: SACKS, FRANK M (contact)

PROJECT_TERMS: Acute;Adult;Avena sativa;beef;Behavior;Biological Markers;biomarker development;Biomarker of Dietary Intake;Blood;Bread;Catalogs;Chickens;cigarette smoking;Collaborations;Complement;Cotinine;Diet;dietary;Dietary intake;Dietary Practices;Disputes;Dose;Drug Kinetics;Eating;Epidemiology;epidemiology study;Fasting;feeding;Food;food consumption;Fostering;Frequencies;Goals;Grain;Health;Healthy Eating;Hospitals;Hour;Human;Intervention;Life Style;Literature;Measurement;Measures;medical schools;metabolomics;Methods;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Nutrient;nutrition;Nutritional Study;Outcomes Research;Patient Self-Report;Plasma;Population;population based;Population Heterogeneity;Population Study;Potato;Prevention strategy;Primary Prevention;Productivity;Proteins;Public Health Schools;Questionnaires;Reporting;Research Design;Research Personnel;Resources;response;Sampling;Soybeans;specific biomarkers;Technology;Time;tool;United States;United States Department of Agriculture;United States National Institutes of Health;Universities;Urine;Wheat;Work

PROJECT_TITLE: Intervention Core for the Dietary Biomarkers Development Center at Harvard University


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Rare Diseases;Urologic Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative Prune Belly Syndrome (PBS) is a severe human urologic disorder with poorly understood genetic causes. DNA mutations in the X-linked gene filamin A (FLNA) identified in PBS cases will be tested to find their dysfunctional effects critically altering bladder detrusor smooth muscle development and disrupting binding to distinct partners, to guide future treatment strategies.

PI_NAMEs: BAKER, LINDA A. (contact);QIN, JUN ;ZENT, ROY

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: 2 year old;abdominal wall;Acceleration;Actins;Adhesions;Affect;Age;Amniotic Fluid;Animal Model;Bilateral;Binding;Binding Sites;Biochemical;Bladder;Bladder Control;Bladder Dysfunction;bladder surgery;C-terminal;Calpain;Catheterization;Cell Physiology;Cell Shape;Cells;Cessation of life;Clinical;Complex;congenital anomaly;Connective Tissue;Cryptorchidism;Deposition;design;detrusor underactivity;Development;developmental genetics;Dialysis procedure;Dimerization;disability;DNA Sequence Alteration;Dysplasia;Embryo;experience;Exposure to;Extracellular Matrix;F-Actin;fetal;Fetal Lung;filamin;Focal Adhesions;Froehlich's Syndrome;Functional disorder;Future;gain of function;Genes;Genetic;Genetic study;Genetic Transcription;genetic variant;gestational hypoxia;Goals;Histologic;Human;Human Genetics;Hydronephrosis;Hypoxia;Immunoglobulins;ineffective therapies;Integrin beta Chains;Integrin Binding;Integrins;Kidney;Kidney Transplantation;Knowledge;Life;Ligand Binding;Link;loss of function;lung development;male;Masks;mechanotransduction;Mediating;Medical Care Costs;Membrane;Microscopy;Missense Mutation;Molecular;Molecular Conformation;monomer;Morbidity - disease rate;Morphogenesis;mouse development;multidisciplinary;Mus;Muscle;Muscle Contraction;Muscle Development;Muscle function;mutant;Mutant Strains Mice;Mutation;myogenesis;N-terminal;Operative Surgical Procedures;Organ;Pathology;Patients;Pharmacotherapy;Phenotype;postnatal;pressure;Principal Investigator;Prognosis;programs;protein crosslink;protein function;protein structure;Proteins;Publications;Quality of life;receptor;Regulation;Relaxation;renal damage;Respiratory System;response;Rod;Role;Secondary to;Signal Pathway;Signal Transduction;Signaling Molecule;skeletal;Smooth Muscle;Smooth Muscle Myocytes;Source;stillbirth;Stimulant;Stress;Stretching;structural biology;Survivors;Syndrome;System;Tail;Techniques;Testing;Therapeutic;Thick;tool;transmission process;treatment strategy;Ureter;Urethra;Urinary tract;Urine;urologic;Urologic Diseases;Work

PROJECT_TITLE: Prune Belly Syndrome: Mechanisms of Filamin A Mutations

STUDY_SECTION: KMBD

STUDY_SECTION_NAME: Kidney Molecular Biology and Genitourinary Organ Development[KMBD]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Microbiome;Nutrition;Precision Medicine;Prevention

PI_NAMEs: CLISH, CLARY B (contact)

PROJECT_TERMS: Acute;Address;Algorithms;Award;Biological;Biological Assay;Biological Markers;biomarker development;biomarker discovery;Biomarker of Dietary Intake;biomarker validation;Charge;chemical property;cohort;Collaborations;Complement;Contracts;Coupled;Data;Data Analyses;data sharing;Dedications;design;dietary;Dietary intake;Equipment;experience;feeding;Food;Goals;Human;Human Microbiome;Hybrids;instrumentation;Intervention;Intervention Trial;Ions;Libraries;Lipids;Liquid Chromatography;Machine Learning;Measurement;Measures;Metabolic;metabolomics;metabolomics resource;Methods;microbiome;Molecular;novel;Nutrient;Participant;Physical activity;physical property;Plasma;Procedures;programs;Protocols documentation;Reference Standards;Resolution;Resources;Sampling;Specimen;Structure;System;tandem mass spectrometry;targeted biomarker;Technology;Trans-Omics for Precision Medicine;Transducers;U-Series Cooperative Agreements;United States National Institutes of Health;Universities;Urine;Validation;validation studies

PROJECT_TITLE: Metabolomics Core for the Dietary Biomarkers Development Center at Harvard University


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Nutrition;Prevention

PI_NAMEs: LIANG, LIMING  (contact)

PROJECT_TERMS: analytical method;Benchmarking;Bioinformatics;Biological Markers;biomarker development;biomarker discovery;biomarker performance;biomarker validation;Biometry;Calibration;clinical phenotype;Clinical Trials;cluster computing;cohort;Cohort Studies;Collaborations;Consultations;Data;Data Analyses;Data Coordinating Center;data exchange;data harmonization;data management;Data Set;data sharing;data standards;data submission;design;Development;Diet;dietary;Dietary intake;Dietary Intervention;Dietary Practices;Discriminant Analysis;Disease;Disease Outcome;Dose;Drug Kinetics;Eating;Ensure;Epidemiology;epidemiology study;Equation;Ethnic Population;Evaluation;feeding;Food;Food Analysis;Future;genome wide association study;gut microbiota;Health;high dimensionality;High Performance Computing;improved;Incidence;Individual;interdisciplinary approach;interest;Intervention;Kinetics;large datasets;machine learning method;Measurement;Mediation;Mendelian randomization;Metabolic;metabolomics;Methodology;Methods;Modeling;Modification;multi-ethnic;Multiomic Data;multiple omics;novel;nutrition;nutritional epidemiology;Performance;Phase;Plasma;power analysis;Production;prospective;Protocols documentation;Quality Control;racial population;response;Sampling;Secure;sex;statistics;synergism;Universities;Urine;Validation;Work

PROJECT_TITLE: Data Analysis Core for the Dietary Biomarkers Development Center at Harvard University


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Cancer;Clinical Research;Hematology;Lung;Lung Cancer;Lymphatic Research;Lymphoma;Rare Diseases;Rheumatoid Arthritis

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Patients with rheumatoid arthritis (RA) have an increased incidence of cancer, especially lymphoma and lung cancer, compared to the general population and to date relatively little is known about the safety of standard immunosuppressives for RA in patients with active or recently (< 5 years since diagnosis) diagnosed cancer. Little is also known about how to support decision-making for these patients who have at least two major comorbid conditions and may be under the care of multiple different specialists. The central focus of this proposal is to advance the evidence-base around use of immunosuppressive medications among patients with RA who have active or recently diagnosed cancer and to provide a foundation for shared decision making to ensure alignment between treatment decisions and the values, goals, and preferences of individual patients.

PI_NAMEs: SINGH, NAMRATA  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: American;cancer diagnosis;Cancer Etiology;cancer risk;career development;Caring;Cause of Death;Cessation of life;Characteristics;clinical decision-making;clinical practice;Collaborations;comorbidity;comparative effectiveness;comparative safety;Data;Databases;Decision Aid;Decision Making;Development;Diagnosis;Disease-Modifying Second-Line Drugs;Ensure;evidence base;experience;Family;Family member;follow-up;Foundations;Funding;Future;General Population;Goals;Guidelines;Immune response;Immunosuppressive Agents;Impairment;improved;Incidence;Individual;individual patient;Interview;Knowledge;Lung Lymphoma;Lymphoma;Malignant neoplasm of lung;Malignant Neoplasms;member;Mentors;Mentorship;Methodology;Methods;mortality;Newly Diagnosed;Nurse Practitioners;Oncologist;Outcome;Outcomes Research;Patient Care;patient oriented;patient population;Patient-Focused Outcomes;Patients;Perception;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacotherapy;Population;preference;primary care provider;Process;Property;Qualitative Research;Recording of previous events;Recurrence;Research;Research Design;Research Methodology;Research Personnel;Retrospective cohort study;Rheumatism;Rheumatoid Arthritis;rheumatologist;Risk;Safety;Sample Size;Shapes;shared decision making;Signal Transduction;skills;Smoking;Specialist;Stage at Diagnosis;standard care;Testing;Training;treatment and outcome;treatment guidelines;treatment planning;Treatment Protocols;tumor;Tumor stage;United States Department of Veterans Affairs;Universities;Veterans;Washington;willingness

PROJECT_TITLE: Improving shared decision-making around the use of disease modifying anti-rheumatic drugs in patients with rheumatoid arthritis and cancer

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Mental Health;Networking and Information Technology R&D (NITRD);Pain Research;Patient Safety;Physical Activity;Prevention;Rehabilitation;Telehealth;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The proposed research will determine the efficacy of eHealth Mindful Movement and Breathing (eMMB) for improving postoperative pain, psychological distress, and other surgical outcomes among women undergoing surgery for suspected gynecologic malignancies. eMMB is a brief intervention that adapts yoga with the intention to remove key barriers to participation around the time of surgery and mitigate the transition from acute to chronic pain. If eMMB is efficacious, this low-cost intervention has the potential to be widely implemented and generalizable to other surgical procedures, and thus to substantially reduce the growing population affected by chronic pain.

PI_NAMEs: SOHL, STEPHANIE JEAN (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: acceptability and feasibility;Acute;Acute pain management;Address;Affect;Affective;Aftercare;Anxiety;associated symptom;attentional control;Behavioral;biobehavior;Biological;Breathing;brief intervention;Cancer Patient;cancer surgery;Cancer Survivor;cancer therapy;Caring;Chronic;chronic pain;Clinical;clinical care;clinical practice;Cognitive;Data;depressive symptoms;Diagnosis;Dimensions;Distress;Early Mobilizations;effectiveness/implementation study;efficacy evaluation;eHealth;Exercise;experience;Funding;Future;future implementation;Goals;Guidelines;Gynecologic Oncology;Gynecologic Surgical Procedures;Health system;Heart Atrium;Hospitalization;implementation determinants;implementation strategy;implementation study;improved;innovation;instructor;Intention;Intervention;intervention cost;Interview;Length of Stay;Long-Term Effects;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Mediating;Meditation;Mental Depression;Mind-Body Intervention;mindfulness;Movement;multimodality;National Cancer Institute;Nonpharmacologic Therapy;Operative Surgical Procedures;opioid use;Outcome;Pain;pain catastrophizing;pain chronification;Pain intensity;Pain management;pain reduction;pain symptom;Participant;Patients;Perioperative;Physical Function;Pilot Projects;Population;Postoperative Pain;Postoperative Period;prevent;primary outcome;programs;Provider;psychological distress;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Recovery of Function;Relaxation;remote delivery;Reporting;Research;Research Infrastructure;Research Personnel;secondary outcome;Sleep disturbances;Structure;Subgroup;surgery outcome;Surgical Management;Surgical Oncology;surgical pain;Symptoms;Testing;Time;Travel;treatment as usual;treatment guidelines;Vulnerable Populations;Woman;women's outcomes;Women's study;Yoga

PROJECT_TITLE: REmotely-delivered Supportive Programs for Improving surgical pain and disTrEss (RESPITE)

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: SUN, QI  (contact)

PROJECT_TERMS: Acceleration;Address;Adult;African American population;Assessment tool;Avena sativa;beef;Betaine;Bioinformatics;Biological Markers;biomarker development;biomarker discovery;biomarker identification;biomarker validation;blood lipid;Blood Pressure;Bread;Calibration;candidate identification;Carbohydrates;Carotenoids;Chickens;Chronic Disease;Citrus Fruit;Clinical;cohort;Cohort Studies;Complex;Consumption;cost effective;Coupled;Data;Data Analyses;data submission;Development;Diet;Diet Monitoring;Diet Records;dietary;Dietary Assessment;Dietary Component;Dietary Fiber;Dietary Intervention;Dietary Practices;Disease;Disease Management;disorder prevention;doubly-labeled water;Drug Kinetics;Eating;Energy Intake;Equation;Evaluation;experience;Fatty Acids;feeding;Folic Acid;Follow-Up Studies;Food;Foundations;Frequencies;Future;Health;Health Professional;Hispanic;Hour;Human;improved;indexing;Individual;innovation;Intake;Intervention;intervention effect;Isoflavones;Knowledge;Life Style;Light;Measurement;Measures;men;Metabolism;metabolomics;Methodology;Methods;microbial;microbiome;microbiome composition;multi-ethnic;multidisciplinary;Nitrogen;novel;novel marker;Nurses' Health Study;Nutrient;nutrition;Nutritional;nutritional epidemiology;Nutritional Study;Observational Study;Participant;Patient Self-Report;Pattern;Performance;personalized nutrition;Phase;Physical activity;Plant Proteins;Plasma;Population;Potassium;Potato;precision nutrition;Prevention;Proline;Property;Proteins;Questionnaires;randomized trial;Recovery;Reporting;Research;Research Personnel;Resources;response;Rye cereal;Sampling;Scientist;Series;Sodium;soy;specific biomarkers;Statistical Data Interpretation;Strategic Planning;Study of Latinos;Techniques;Testing;Time;tool;United States Department of Agriculture;United States National Institutes of Health;Universities;Unsaturated Fats;urinary;Urine;Validation;validation studies;Vascular Plant;Wheat;Woman;Work

PROJECT_TITLE: Biomarkers Project for the Dietary Biomarkers Development Center at Harvard University


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Opioid Misuse and Addiction;Opioids;Pain Research;Palliative Care;Prevention;Social Determinants of Health;Substance Misuse

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative: Psychological suffering has been identified as a driver of opioid misuse in individuals with cancer on opioid therapy. However, there are no interventions that target this known problem in this unique population with increased vulnerability to develop substance use disorder (SUD). Therefore, the goals of this study are to: (1) examine the feasibility and acceptability of a novel behavioral intervention to reduce the risk of opioid misuse in cancer patients on opioid therapy by way of reducing psychological suffering; (2) pilot test the refined intervention for this high-risk population; and (3) estimate effect sizes for a future, adequately powered RCT.

PI_NAMEs: YUSUFOV, MIRYAM  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acceptability and feasibility;Address;Advanced Malignant Neoplasm;Anxiety;Area;Award;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Model;behavioral outcome;Behavioral trial;cancer care;cancer pain;Cancer Patient;care outcomes;career;career development;Categories;Center for Translational Science Activities;Chemicals;Clinic;Clinical Research;Clinical Sciences;Comprehensive Cancer Center;coping;Dana-Farber Cancer Institute;Data;design;Development;disorder risk;Dissemination and Implementation;Education;Enrollment;Ensure;Environment;Evaluation;Evidence based program;experience;Face;Feedback;Foundations;Fracture;Future;Goals;Government;Health;Health behavior;high risk population;immune function;Individual;Infection;Intervention;intervention refinement;Intervention Trial;Interview;Malignant Neoplasms;Manuals;Measures;medical schools;Mental Depression;Mentorship;Methods;Monitor;neurotoxicity;novel;Oncology;Opioid;opioid misuse;opioid therapy;Outcome;Outpatients;Pain;Pain management;Palliative Care;Participant;patient engagement;patient oriented research;Patients;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;pilot test;pilot trial;Population;Population Intervention;Preparation;prescription opioid;Prevention;primary outcome;Procedures;Process;programs;psychologic;psychological distress;psychological outcomes;psychosocial;Public Health;Qualitative Methods;Quality of life;Randomized;Randomized, Controlled Trials;Recording of previous events;reduced substance use;remote delivery;Replacement Therapy;Reporting;Research;Research Personnel;Resources;Risk;Risk Behaviors;Risk Factors;Risk Management;Risk Reduction;Running;Scientist;Social support;Stress;substance use;Substance Use Disorder;success;symptom management;Targeted Research;Testing;Therapeutic Intervention;therapy development;Training;United States National Institutes of Health;Visit;Waiting Lists

PROJECT_TITLE: A Novel Intervention for Avoidance-Related Opioid Misuse in Patients with Cancer


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - C;Infectious Diseases;Kidney Disease;Liver Disease;Organ Transplantation;Prevention;Transplantation

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Kidney transplantation (KT) is a rapidly-expanding, lifesaving intervention for people living with HIV (PLWH) and end-stage renal disease, yet the landscape of serious post-transplant infections and associated risk factors including immunosuppressive regimens remain undefined. This proposal aims to utilize national KT cohort data to characterize the burden, timing, and spectrum of infections in HIV+ KT recipients, with comparison to HIV- KT controls, in order to evaluate modifiable risk factors and guide potential targeted monitoring and prophylaxis. In addition, we seek to understand whether there are differential infectious risks associated with HIV+ organ donation within the emerging population of HIV-to-HIV KT recently legalized under the HIV Organ Policy Equity (HOPE) Act and under study through the HOPE in Action clinical trials group.

PI_NAMEs: WERBEL, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acute;Affect;Anti-Retroviral Agents;Anti-viral Agents;antimicrobial;Award;Biological;Biology;Candida;Caring;Cessation of life;Clinical;clinical trial analysis;Clinical Trials Cooperative Group;co-infection;Code;cohort;Complex;Cytomegalovirus;Data;Data Analyses;Databases;design;Development;End stage renal failure;Epidemiologic Methods;Equilibrium;Equity;Event;evidence base;Evidence based practice;experience;Factor Analysis;Foundations;Functional disorder;Funding;Goals;Guidelines;hazard;Hepatitis C;Hepatitis C co-infection;Herpesviridae;HIV;HIV Integrase;HIV/HCV;Human Herpesvirus 8;ICD-9;Immunosuppression;improved;Incidence;Infection;Infection prevention;infection risk;Information Systems;Infrastructure;inhibitor;Intervention;Kidney;Kidney Transplantation;Laboratory Markers;large datasets;Legal;Life;Link;Lymphocyte;Measures;Medicare/Medicaid;Mentors;Methods;Modernization;modifiable risk;Molds;Monitor;Multi-Institutional Clinical Trial;multilevel analysis;Mycoses;Nature;novel;Organ;Organ Donations;Organ Donor;Organ Transplantation;Outcome;pathogen;Patients;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacy facility;Physicians;Policies;Population;post-transplant;Predisposition;Prevalence;prevent;Probability;Prophylactic treatment;prospective;Protocols documentation;Regimen;Registries;Reporting;Research Personnel;Risk;Risk Factors;Sample Size;skills;Survival Analysis;T-Lymphocyte;Testing;Training;transmission process;Transplant Recipients;transplant registry;Transplantation;transplantation medicine;United States;Viral;Vulnerable Populations;Weight

PROJECT_TITLE: The Landscape of Serious Infections following Kidney Transplantation in People Living with HIV

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Microbiome

ORG_CITY: KUALA LUMPUR

ORG_COUNTRY: MALAYSIA

ORG_FIPS: MY

ORG_NAME: UNIVERSITY OF MALAYA

PHR: Project Narrative Skin fungal infections and their relationship with the skin microbiome are insufficiently understood, particularly among underserved indigenous populations. These studies is anticipated to identify unique microbes with novel biological pathways and help develop interventions for effectively managing fungal skin infections.

PI_NAMEs: LIM, YVONNE AL  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Affect;Architecture;Arthrodermataceae;Articulation;Bioinformatics;Biological;Cellular biology;Cities;Clinical;Collaborations;Collection;commensal bacteria;Communities;Corynebacterium;Data;Databases;Disease;Disease Progression;effective intervention;epidemiologic data;Epidemiology;epidemiology study;Epithelial Cells;field study;Fungal Genome;fungus;Genetic Variation;Genome;genome analysis;genome sequencing;Genus staphylococcus;Geographic Locations;gut microbiome;gut microbiota;helminth infection;High Prevalence;host-microbe interactions;Household;Human;Immune response;Immunology;Indigenous;indigenous community;Individual;Infection;infection management;Infectious Skin Diseases;Infrastructure;insight;interest;Intramural Research Program;Life Style;Longitudinal Studies;Malaysia;Malaysian;Maps;Metabolic Pathway;Metadata;metagenome;metagenomic sequencing;Metagenomics;Microbe;microbial;microbiome;microbiome alteration;microbiome analysis;microbiome sequencing;Modeling;Morphology;Mycoses;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Native-Born;neglect;novel;pan-genome;Participant;pathogenic fungus;Pathway interactions;Persons;Pilot Projects;Population;Population Study;Prevalence;Probability;Questionnaires;reference genome;Research;Research Personnel;Resources;Rural;Sampling;Scientist;Shotguns;Site;Skin;skin disorder;skin microbiome;Societies;Taxonomy;Therapeutic Intervention;Tinea;Training;transmission process;Trichophyton;underserved community;Underserved Population;United States National Institutes of Health;Universities;Virulence Factors;Visit;whole genome

PROJECT_TITLE: The skin microbiome and fungal infections of indigenous Malaysians

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SAS-W (J1)]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This proposed study examines the role of intergenerational social mobility on persistent Black/White differences in adverse birth outcomes across generations in the United States, focusing on the Deep South. Results of this study may inform future research that will advance our understanding of the cumulative disadvantage of structural racism on Black families in the US, thus pointing us towards future policy interventions targeted at improving health equity.

PI_NAMEs: KAPPELMAN, ABIGAIL LEONA (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Accounting;Address;Adopted;Adoption;adverse birth outcomes;Affect;Biological;Birth;Birth Certificates;Birth Weight;Black Populations;Black race;black women;care outcomes;career;Child;clinical practice;clinical training;Cross-Sectional Studies;Data Set;Deep South;design;Disadvantaged;Discipline of obstetrics;Disparity;disparity elimination;Education;epidemiology study;Etiology;Exposure to;Family;Fellowship;Future;Future Generations;Generations;Genetic Predisposition to Disease;Gestational Age;Goals;Grant;Gynecology;Health;health equity;health inequalities;Health Status;improved;Income;Individual;Inequality;Inequity;Infant;Inherited;innovation;Institution;intergenerational;Intervention;Investigation;Knowledge;Life course epidemiology;Life Cycle Stages;Link;Low Birth Weight Infant;maternal risk;Measurement;Measures;Medical;Medicine;Mentors;Mentorship;Methodology;Modeling;Mothers;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;novel;Outcome;Parents;Persons;Physicians;Policies;Positioning Attribute;Poverty;Pregnancy;Premature Birth;Prenatal care;prevent;protective effect;Psychological reinforcement;Public Health;Race;racial difference;racial disparity;racial population;Research;Research Personnel;Retrospective cohort study;Risk;Risk Factors;Role;Rural Community;Scientist;Signal Transduction;skills;social;social epidemiology;social factors;Social Mobility;Social Sciences;Social status;Socioeconomic Status;Sociology;South Carolina;structural determinants;Structural Racism;Time;Training;Training Programs;United States;Vital Statistics;White Women;Woman

PROJECT_TITLE: An Exploration of the Intergenerational Persistence of Health and Social Status Contributing to Racial Disparities in Birth Outcomes in South Carolina

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Biotechnology;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Pediatric;Regenerative Medicine;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: NARRATIVE This Tenth (11th) Annual Pediatric Transplant and Cellular Therapy Consortium (PTCTC) Educational Meeting on “The First 100 Days” after stem cell transplant will be attended by interdisciplinary clinicians and scientists, including minorities and underrepresented groups. The educational program will facilitate new knowledge in this field, promote collaborative research and enhance the maturation of young investigators in pediatric hematopoietic cell transplantation. Further, this conference will bridge the clinical and scientific gap between pediatric and medical HCT specialists treating children, adolescents, and young adults after stem cell transplant.

PI_NAMEs: DANDOY, CHRISTOPHER EUGENE (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Acute;Acute Graft Versus Host Disease;Adolescent and Young Adult;Adult;American;Award;Basic Science;burnout;career development;Caring;Cell Therapy;Child;Childhood;Clinical;clinical care;clinical practice;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Communities;curative treatments;Dedications;design;Disabled Persons;diversity and inclusion;Education;Effectiveness;Endothelium;Ensure;ethnic minority;Event;evidence based guidelines;Fostering;Future;Goals;health care quality;Health Personnel;Health Services Research;Hematopoietic Stem Cell Transplantation;Immunology;improved;improved outcome;Individual;Infection;Information Dissemination;Injury;innovation;Institution;International;Joints;Knowledge;Medical;Medical Economics;meetings;Mentors;microbiome;Minority Groups;Mission;mortality;novel;novel therapeutics;Oncology;Oral;Parents;Patients;Pediatric Hematology;Physicians;Policies;posters;preservation;prevent;Prevention;professor;programs;Publications;Quality of life;racial minority;Research;Research Personnel;response;Safety;Science;Scientist;screening;Site;Societies;socioeconomics;Specialist;Standardization;Stem cell transplant;success;survivorship;symposium;Testing;thrombotic;tool;Translational Research;Transplant Recipients;transplant survivor;Transplantation;transplantation therapy;Travel;treatment risk;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Veno-Occlusive Disease;Washington;Woman;young adult

PROJECT_TITLE: The 11th Annual PTCTC Educational Meeting, The First 100 Days After Stem Cell Transplant

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (J2)]