NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Pediatric - AIDS;Substance Misuse

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Project Narrative There is a global call to focus on the particular needs of youth living with HIV, which represents an important period of cognitive, emotional and social change, with the brain undergoing structural and functional development as it matures. Youth living with HIV in South Africa comprise two different sub-populations: those who are infected through sexual exposure (behaviorally infected) and those infected through parent-to-child transmission (perinatally infected), now surviving into young adults. The primary goal of the proposed study is to follow a cohort of perinatally HIV-1 infected, matched behaviorally infected and HIV-uninfected controls from Cape Town Adolescent Antiretroviral Cohort, into early adulthood in order to understand the individual and combined effects of substance use and HIV infection on immune dysregulation, viral reservoir diversity, brain structure and function, neurocognitive functioning and mental health.

PI_NAMEs: HOARE, JACQUELINE  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: 21 year old;Adolescence;Adolescent;adolescent substance use;Adult;Affect;Affective;Africa South of the Sahara;Age;age group;Alcohols;Anti-Retroviral Agents;antiretroviral therapy;arterial spin labeling;Behavior Control;Behavioral;Birth;Brain;brain abnormalities;Brain imaging;Cannabis;CD4 Antigens;Cells;Central Nervous System;Central Nervous System Diseases;Child;Chronic;Cognitive;cohort;Collaborations;comparison group;Consumption;critical period;Data;Dedications;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;DNA;emerging adult;Emotional;Epidemic;Evolution;executive function;experience;Face;fecal microbiome;Female Adolescents;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Goals;Growth;Health;heart function;high risk;HIV;HIV envelope protein;HIV Infections;HIV Seropositivity;HIV-1;HIV/AIDS;Image;imaging facilities;imaging modality;Immune;Immune response;Immunologic Markers;in vivo;Incidence;Individual;Infection;Inflammatory;inflammatory marker;innovation;insight;Knowledge;Limbic System;Link;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Mediating;Mental Health;Methods;Microglia;morphometry;multimodal neuroimaging;myelination;Nature;Neurocognitive;Neurocognitive Deficit;neurodevelopment;Neuroimmune;Neurologic Deficit;Outcome;Outcome Measure;parent project;Parents;Participant;Pathogenesis;Pathway interactions;Pattern;Perinatal;perinatal HIV;Peripheral;Peripheral Blood Mononuclear Cell;Peripheral Nervous System;Phase;Phenotype;Population;Prefrontal Cortex;prospective;Research;Research Infrastructure;resilience;Respiratory physiology;response;Rest;Rewards;Risk;Role;Shapes;Social Change;South Africa;spectrograph;Spectrum Analysis;Structure;substance use;synaptic pruning;Time;Tobacco;transmission process;Universities;Viral;Viral reservoir;Virus;virus host interaction;young adult;Youth

PROJECT_TITLE: Cape Town Adolescent Antiretroviral Cohort- Substance, Imaging, Mental Health (CTAAC-SIM)


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative This supplement aims to advance preventive HIV vaccine development by enhancing the analytical capacity of the HVTN SDMC to evaluate vaccine candidates that seek to induce broadly neutralizing antibody responses. Through improving bioinformatics and analytics tools for B-cell responses and expanded capacity in carrying out such analyses, this supplement supports the essential mission of the HVTN and accelerates vaccine research that could lead to significant reductions in the rates of HIV transmission and acquisition, ultimately improving public health outcomes globally.

PI_NAMEs: GILBERT, PETER B. (contact);HUANG, YUNDA ;JANES, HOLLY

PROGRAM_OFFICER_NAME: CALDER, THOMAS JAMES

PROJECT_TERMS: Acceleration;Address;Affinity;analytical tool;Antibodies;Antibody Response;Antigens;B cell repertoire;B-Cell Antigen Receptor;B-cell receptor repertoire sequencing;B-Lymphocytes;Bioinformatics;bioinformatics tool;Biological Assay;Biometry;Biostatistical Methods;Clonality;Complex;computer infrastructure;Data;Data Coordinating Center;Data Set;Databases;design;distributed data;Environment;Evolution;expectation;Frequencies;Funding;Generations;Grant;HIV;HIV vaccine;HIV Vaccine Trials Network;HIV-1;improved;Laboratories;Leadership;Mature B-Lymphocyte;Measures;Medicine;Mission;Molecular;National Institute of Allergy and Infectious Disease;Nature;neutralizing antibody;open source;open source tool;Outcome;Phase;Phenotype;phenotypic data;prevent;Preventive;programs;Protocols documentation;Public Health;Ramp;Reporting;Reproducibility;research study;response;Running;Secure;Standardization;success;transmission process;user friendly software;vaccine candidate;vaccine development;vaccine evaluation;Vaccine Research;vaccine-induced antibodies;Vaccines;Work

PROJECT_TITLE: B Cell Bioinformatic Supplement: HIV Vaccine Trials Network (HVTN)


ADMINISTERING_IC: EB

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

ORG_CITY: Chicago

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: NARRATIVE HIV viral load monitoring has been a key component of medical care and public health for individuals living with HIV; however, we need better technologies for home-based or point-of-care diagnostics. The overall objective of this supplemental funding to C-THAN is to conduct market research and a quantitative conjoint analysis for HIV viral load diagnostics in the United States. Our team will also perform project reviews, participate as viability/steering panel members, and provide expertise to teams developing novel point-of-care diagnostic technologies for HIV viral load.

PI_NAMEs: ACHENBACH, CHAD J (contact);MCFALL, SALLY MAUREEN;MURPHY, ROBERT LEO

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Caring;detection limit;Diagnostic;diagnostic technologies;Emerging Communicable Diseases;Fingers;Funding;Health Personnel;HIV;HIV/AIDS;Home;Individual;innovation;International;Internet;Market Research;Medical;member;Methods;Monitor;Needles;novel;Participant;Patients;Peer Review;point of care;Point of Care Technology;point-of-care diagnostics;preference;Public Health;Publications;Publishing;RADx;Research;sample collection;Surveys;symposium;Technology;Testing;United States;Venipunctures;Viral Load result

PROJECT_TITLE: RADx HIV Viral Load Supplement 2.0


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Alzheimer’s disease is a public health crisis in the US and a growing health disparity, with African Americans at disproportionate risk for the disease compared to non-Hispanic whites. This project proposes to investigate earlier-life, individual- and community-level stress exposures—adverse life circumstances and trauma (ie, extreme poverty, residential instability, crime, police and community violence, incarceration, racial discrimination), mental disorders and their symptoms, and poor sleep (eg, abnormal duration, fragmentation)—as determinants of known midlife risk factors for poor cognitive outcomes in later life in two high-risk, predominantly African American cohorts followed longitudinally for 35 years. Results will help clarify links of stress exposures with estimated risk at midlife for later-life dementia, identify vulnerable subgroups for targeted prevention of Alzheimer’s disease, elucidate the role of social inequities in determining racial disparities in Alzheimer’s dementia, and establish a midlife cognitive baseline for future longitudinal follow-up of these valuable cohorts.

PI_NAMEs: REBOK, GEORGE W. (contact);THORPE, ROLAND J.

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Academic achievement;Adult;Affect;African American;African American population;Age;Aging;Alcohols;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Childhood;Cognitive;cognitive performance;cohort;Communities;community violence;conduct problem;Crime;Dementia;dementia risk;Diabetes Mellitus;Diagnosis;disorder risk;Drug usage;early life stress;Education;Epigenetic Process;follow-up;Future;Genetic;health disparity;Health protection;high risk;Home;Hypertension;Imprisonment;Individual;Inequity;Inflammation;Intervention;Intervention Studies;Interview;late life;Length;Life;Life Cycle Stages;Link;Measures;Mental disorders;Methylation;middle age;Modification;Not Hispanic or Latino;Obesity;Occupational;Outcome;Outcome Study;Participant;Physiological;Police;poor sleep;Poverty;Prevention;preventive intervention;prospective;protective factors;Public Health;Race;racial discrimination;racial disparity;Risk;Risk Estimate;Risk Factors;risk variant;Role;sex;Sleep;Social support;Stress;Subgroup;Symptoms;telomere;Trauma;traumatic event

PROJECT_TITLE: Earlier-Life Predictors of Midlife Risk Factors for Dementia: A 35-Year Follow-up Wallace Admin Suppl


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Chronic Pain;Clinical Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Pain Research;Palliative Care;Patient Safety

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative . Over 1 million older adults with serious illness have major surgery or severe trauma each year, and palliative care delivered alongside surgical care can help relieve patient suffering, improve post- operative outcomes, and reduce healthcare utilization. Although seriously ill surgical patients benefit from palliative care, they are less likely than other patients to receive it. The proposed study will provide an innovative and layered examination of the role of palliative care in surgery in order to directly inform bedside clinical decisions and the implementation of targeted palliative care interventions to improve care for older seriously ill surgical patients.

PI_NAMEs: COOPER, ZARA R (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Acute;Address;Administrator;Adult;care delivery;Caregiver Burden;caregiver strain;Caregivers;caregiving;Caring;Certification;Clinical;clinical practice;cohort;Colectomy;Communities;Community Hospitals;contextual factors;Coronary Artery Bypass;daily functioning;Data;Data Sources;Documentation;Elderly;electronic health data;Emergency department visit;end of life care;End stage renal failure;experience;functional decline;Goals;Guidelines;Health;Health and Retirement Study;health care service utilization;health data;health goals;Health system;Healthcare;Healthcare Systems;high risk;hip replacement arthroplasty;hospice environment;hospice utilization;Hospitalization;Hospitals;human old age (65+);Impaired cognition;implementation barriers;improved;improved outcome;informal caregiving;information gathering;innovation;Intervention;Interview;knee replacement arthroplasty;Life;Link;Lower Extremity;Malignant Neoplasms;Manuals;Massachusetts;Measures;Medicare claim;Mental Depression;Methodology;Methods;mortality;Natural Language Processing;novel;Nurses;nursing home length of stay;older adult;older patient;Operative Surgical Procedures;Outcome;Outcomes Research;Pain;Pain Measurement;Palliative Care;patient oriented;Patient-Focused Outcomes;Patients;Perioperative;Physicians;Population;Postoperative Period;pragmatic implementation;Process;Proxy;psychologic;Qualitative Methods;Quality of life;reduce symptoms;Research;Retrospective cohort;revascularization;Risk;Role;severe injury;Site;social;Social Workers;Specialist;surgery outcome;Surgical complication;Surgical Injuries;Testing;Trauma;United States National Institutes of Health;Work

PROJECT_TITLE: A Layered Examination of the Patient Experience to Elucidate the Role of Palliative Care in Surgical Care for Seriously Ill Older Adults

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PI_NAMEs: HOPE, THOMAS  (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TITLE: Project 1: Dissecting Persistent Virus Reservoirs in Tissues


PROJECT_TITLE: Administrative Core


PI_NAMEs: VILLINGER, FRANCOIS J (contact)

PROJECT_TITLE: Nonhuman Primate Core


PI_NAMEs: LORENZO-REDONDO, RAMON  (contact)

PROJECT_TITLE: Project 2: Revealing Viral Population and Host Environment Dynamics of SIV Tissue Reservoir


PI_NAMEs: O'SULLIVAN, JEREMY A (contact)

PROJECT_TITLE: Exploration into the Forgotten HIV Reservoir with Models of HIV/SIV Persistence in Mucosal Tissues


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSURGERY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: RELEVANCE (See instructions): Aging and brain disorders such as dementia and epilepsy lead to deficits in spatial navigation and memory,  which are vital to daily functioning and independence. Here, we will identify key neural circuits of navigation  and memory in humans, thus helping explain the cause of navigational disorders and memory deficits. This will support the development of navigational aids and guide future circuit-based interventions to alleviate  memory loss, thus improving the lives of persons with memory deficits, disorientation, and mental illnesses.

PI_NAMEs: JACOBS, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Aging;Animals;Behavior;Biological Models;Brain;Brain Diseases;cell type;Cells;Cognition;Cognitive;cognitive function;Complement;Complex;Computer Models;daily functioning;Dementia;design;Development;Diffuse;Disease;Disorientation;Electrical Stimulation of the Brain;Elements;Environment;Epilepsy;Event;experimental study;Feedback;Future;Generations;Hippocampus;Human;Impairment;improved;Individual;insight;Instruction;Intervention;Knowledge;Lead;Lesion;Life;Link;Location;Maps;medial temporal lobe;Memory;Memory Disorders;Memory impairment;Memory Loss;memory recall;Mental disorders;mental representation;Methods;Modeling;neural;neural circuit;neuromechanism;neuron loss;Neurons;Noise;patient engagement;Patients;Performance;Persons;Play;Research;Retrieval;Role;Scheme;skills;spatial memory;Testing;Time;Translational Research;virtual reality;way finding;Work

PROJECT_TITLE: CRCNS: Neural circuits for egocentric and allocentric cognitive maps in humans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (50)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative If we could pinpoint the genes that contribute to resistance against infectious disease, then we would be equipped to efficiently develop personalized gene-based therapies and to precisely target medical and public health interventions to the individuals and populations most at risk. My parent award advances this vision by testing hypotheses for why it has proven so difficult to identify these resistance genes. Our results thus far indicate that the genes contributing to resistance depend critically on how many infectious agents a host encounters (i.e., dose), and this proposed equipment supplement would increase the precision, replication, and versatility of our experiments to systematically characterize how, and why, dose dictates infection outcomes and the underlying genetics of resistance.

PI_NAMEs: GIBSON, AMANDA K (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Accounting;Address;Biological Models;Caenorhabditis elegans;Communicable Diseases;Communities;Dependence;design;digital;Disease Outcome;Dose;Environment;Epidemiology;Equipment;Evolution;experimental study;follow-up;gene therapy;Genes;Genetic;genetic resistance;Genetic Variation;Genomics;Genotype;Human;Individual;Infection;Infectious Agent;Infectious Diseases Research;instrument;Medical;Nature;Nematoda;Outcome;Parasite resistance;Parasites;parent project;Phenotype;Population;programs;public health intervention;Research;Resistance;resistance gene;Risk;Sampling;Surveys;Testing;trait;Variant;Vision Tests

PROJECT_TITLE: A general test of the genetic basis of parasite resistance across genetic and environmental contexts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Program Narrative We seek to discover the mechanisms of the dynamic contacts of neighboring cells as well as between cells and the extracellular matrix that hold animal cells together. These junctions additionally communicate signals and control the stress placed upon cells. Since the regulation and dysregulation of cell junctions are fundamental to many biological processes such as development and cancer, our proposed studies are therefore significant to our basic mechanistic understanding that could eventually result in a translational impact.

PI_NAMEs: IZARD, TINA  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Actins;Adherens Junction;Adhesions;alpha catenin;Animals;Binding;Biochemical;Biological Process;Cardiac;Cell Adhesion;Cell membrane;cell motility;Cell Proliferation;Cell-Cell Adhesion;Cell-Matrix Junction;Cells;Communication;Cryoelectron Microscopy;Cytoskeleton;Development;Epithelium;Extracellular Matrix;fast protein liquid chromatography;Focal Adhesions;Foundations;Funding;Gap Junctions;Genes;Homeostasis;insight;Intercellular Junctions;Knowledge;Laboratories;Link;Lipid Binding;Malignant Neoplasms;mechanotransduction;Mediator;Molecular;National Institute of General Medical Sciences;Play;prevent;programs;Protein Isoforms;protein purification;Regulation;Resolution;Role;Signal Transduction;Stress;Structure;System;Talin;Tissues;Transcript;translational impact;translational potential;transmission process;Vinculin

PROJECT_TITLE: Molecular Mechanisms of Cell Adhesion


ADMINISTERING_IC: HL

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Lower respiratory tract infections, such as community-acquired pneumonia, represent a major cause of hospitalization and death worldwide. This project seeks to understand the long-term outcomes and heterogeneity of pneumonia due to an important tropical pathogen. The results of this proposal may help provide the basis for new treatments and management approaches to improve long-term outcomes in pneumonia.

PI_NAMEs: COSTON, TAYLOR DAVID (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute Disease;acute infection;Admission activity;adverse outcome;Area;Automobile Driving;Award;Biological;biological heterogeneity;Biological Markers;burden of illness;Burkholderia pseudomallei;career;Categories;Cessation of life;Clinical;clinical heterogeneity;clinical translation;Cluster Analysis;community acquired pneumonia;community burden;comorbidity;Country;COVID-19 pandemic;Critical Care;cytokine;Data;Data Set;Development;Enrollment;Environment;Epidemiologic Methods;Ethics;Etiology;Faculty;follow-up;Funding;Future;Genetic Variation;global health;Goals;Gram-Negative Bacteria;Health;Heterogeneity;Hospital Mortality;hospital readmission;Hospitalization;Hospitals;IL8 gene;Immune response;improved;individualized medicine;Infection;Inflammation;Inflammatory;insight;Integration Host Factors;Interleukin-6;K-Series Research Career Programs;Laboratories;longitudinal analysis;Longitudinal cohort;low and middle-income countries;Lower Respiratory Tract Infection;Lung;lung health;Mechanical ventilation;Mediating;Medicine;Mentorship;mortality;novel;Outcome;pathogen;Patient Admission;Patients;Physicians;Plasma;Pneumonia;Predisposition;Prevention;Prospective cohort;readmission rates;Recovery;Research;Research Personnel;Research Project Summaries;Research Training;Risk;Risk Factors;Sampling;Scientist;Severities;Severity of illness;Shock;skills;Subgroup;Survivors;targeted treatment;Techniques;Testing;Thailand;Therapeutic;TNF gene;Training;translational physician;Universities;Washington;Work

PROJECT_TITLE: Determinants of long-term outcomes and heterogeneity in Gram-negative community-acquired pneumonia


NIH_SPENDING_CATS: Aging;Arthritis;Biotechnology;Osteoarthritis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE As people age they lose the ability to heal from injuries or diseases like osteoarthritis, partially due to a reduced ability of old stem cells to differentiate and an inhospitable tissue environment that no longer supports repair. To address this, we propose to 1) activate SIRT6, a sirtuin that can epigenetically reverse age-associated changes in stem cells and 2) inhibit apoptosis signal regulating kinase 1 (ASK1), a protein associated with cell death and inflammation, in the tissue environment. We will test the ability of this novel dual strategy to enhance stem cell differentiation and promote a more regenerative tissue environment in articular cartilage defect models of aged animals.

PI_NAMEs: COLLINS, JOHN A (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;Age;age related;age related changes;age-related disease;aged;Aging;aging population;animal old age;Animals;articular cartilage;Autologous;Body System;Cartilage;cartilage regeneration;cartilage repair;cell age;Cell Death;clinically relevant;Defect;Degenerative polyarthritis;Disease;efficacy evaluation;Environment;Epigenetic Process;epigenetic regulation;Failure;Female;healing;immune function;In Vitro;Inflammation;Inflammatory;Inhibition of Apoptosis;Injury;innovation;insight;joint injury;Joints;Life;Macrophage;male;MAP3K5 gene;Miniature Swine;Modeling;Mus;Natural regeneration;novel;novel strategies;Persons;pre-clinical;Proteins;Rattus;regenerative;regenerative therapy;regenerative tissue;Rejuvenation;repaired;response;Risk Factors;Rodent;Rodent Model;Role;Sirtuins;stem cell differentiation;stem cell therapy;stem cells;Testing;Tissues

PROJECT_TITLE: ASK1 inhibition as a novel strategy to regulate immune function and promote regeneration


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOCA RATON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

PHR: Project Narrative There is inconsistent evidence indicating that Bilingualism might increase Cognitive Reserve and or resilience (CR/R). We propose a multidisciplinary longitudinal study to compare Bilinguals and Monolinguals with amnestic Mild Cognitive Impairment from an equivalent cultural background in neuropsychological and neuroimaging data. Our findings will advance understanding of the complex interactions between neural, environmental, and sociocultural factors and the role of Bilingualism in CR/R in MCI, paving the way for new targets for interventions and providing fundamental insight into the role of language(s) in the aging brain.

PI_NAMEs: COOMBES, STEPHEN ;ROSSELLI, MONICA  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Acculturation;Address;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;amnestic mild cognitive impairment;Area;bilingualism;Biological;Brain;Cognitive;cognitive change;cognitive reserve;cohort;community engaged research;Complex;Cultural Backgrounds;Data;Dementia;Educational Status;Ensure;Environmental Risk Factor;Ethnic Population;Failure;Hispanic;Hispanic Populations;Impaired cognition;indexing;innovation;insight;Intervention;Language;Latino Population;Learning;longitudinal dataset;longitudinal design;Longitudinal Studies;Magnetic Resonance Imaging;Measures;mild cognitive impairment;multidisciplinary;multimodal neuroimaging;neural;neuroimaging;neuroprotection;Neuropsychology;older adult;outreach;Population;Positioning Attribute;Prospective, cohort study;Psyche structure;recruit;Research;Research Personnel;resilience;Resistance;Risk;Role;Semantics;social culture;sociocultural determinant;Spanish;Spanish/English;Stress Tests;theories;United States National Institutes of Health

PROJECT_TITLE: Diversity Supplement: Neuropsychological Norms for Bilingual Spanish speaking Hispanic/Latinos


ADMINISTERING_IC: LM

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Networking and Information Technology R&D (NITRD);Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: This supplemental project will increase the availability of culturally relevant and low-cost DASH (Dietary Approaches to Stop Hypertension) for low-income African American (AA) women and increase the generalizability of a targeted, useful, and usable interactive health information resource. Community-engaged approaches will be used to identify culturally preferred recipes and modify them into low-cost DASH recipes with AA women living in two low-income AA communities. Modified DASH recipes will be included in the health information resource and marketed to a broader audience through existing community-based partnerships and networks.

PI_NAMEs: WHITE, BRANDI MICHELLE (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Accounting;Adherence;adherence rate;Administrative Supplement;Adopted;Affect;African American;African American population;African American Women;American;Asian;Awareness;Behavioral;blood pressure reduction;Books;Budgets;built environment;Cardiac health;Cardiovascular Diseases;cardiovascular disorder risk;Characteristics;Chicago;Cities;Communities;community engaged approach;community organizations;Complex;cooking;cost;DASH diet;Data;Diet;Diet Modification;Disparity;Economics;Educational workshop;Effectiveness;effectiveness evaluation;evidence base;Financial Hardship;Food;food insecurity;Future;Goals;Government;Guidelines;healing;Health;Health Care Costs;health disparity populations;Health Food;Healthy Eating;Heart;high risk;Hispanic;Hypertension;improved;Information Resources;Intervention;Interview;Kentucky;Knowledge;lifestyle intervention;Low income;Marketing;meetings;Methods;modifiable risk;Outcome;Outcome Study;parent project;Parents;Participant;Pathway interactions;Peer Review;Persons;preservation;prevent;Professional Organizations;Psychosocial Stress;Public Housing;Publications;racial discrimination;Recipe;recruit;Research;Resources;Risk;Risk Factors;Risk Reduction;Social Environment;social health determinants;sociodemographics;Subgroup;United States National Library of Medicine;usability;Woman;Work

PROJECT_TITLE: Administrative Supplement to Modify Culturally-Relevant Recipes for Low-Income African American Women


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PHR: Narrative Despite the long-term impact of attention deficits on academic performance, life satisfaction, and job performance, identification of attention deficits in young children remains elusive. This project will examine neural markers of attention to determine if they can better predict attention deficits as children age relative to behavioral assessments. This project is directly relevant to the priorities of the National Institute on Alcohol Abuse and Alcoholism because we will examine attention in children with prenatal alcohol exposure who are known to have increased risk for developing attention deficits.

PI_NAMEs: STEPHEN, JULIA MARIE (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: 7 year old;Administrative Supplement;Age;Alcohols;Applications Grants;Attention;Attentional deficit;Behavior assessment;career;Child;Cognitive;cognitive function;cognitive neuroscience;cohort;Computer Models;Data;Data Analyses;Data Collection;data curation;data management;data sharing;Development;Diffusion Magnetic Resonance Imaging;Doctor of Philosophy;Electroencephalography;excitatory neuron;executive function;experience;Exposure to;Faculty;falls;Fetal Alcohol Exposure;Funding;Future;Goals;graduate school;Household;Human;human subject;Impairment;Individual;journal article;Knowledge;Learning;Life;low socioeconomic status;Magnetic Resonance Imaging;Manuscripts;Mediating;meetings;Mentors;Methodology;Methods;National Institute on Alcohol Abuse and Alcoholism;neocortical;neural;neuroimaging;neurophysiology;Neuropsychological Tests;parent grant;parent project;Performance;Performance at work;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;posters;prenatal;Preparation;programs;Protocols documentation;psychologic;Publishing;Pythons;recruit;Reporting;Research;Research Assistant;response;Rest;Risk;Role;Sampling;satisfaction;skills;socioeconomics;source localization;symposium;Talents;Testing;Time;Training;undergraduate research;undergraduate student;United States National Institutes of Health;white matter;Work

PROJECT_TITLE: Attending to all children: Examining the role of alpha oscillations in attention in young children with and without prenatal alcohol exposure (AsCENd) Administrative Supplement

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_DEPT: NEUROLOGY

PHR: Why some cells die while other survive in the brains of patients with synucleinopathies remains uncertain. Herein, we propose to use a new gene editing technology to elucidate the mechanisms driving cell resilience in these neurological disorders. If successful, this strategy may have far-reaching implications for the treatment of synucleinopathies and even perhaps Alzheimer's disease.

PI_NAMEs: PRZEDBORSKI, SERGE E (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Affect;alpha synuclein;Alzheimer's Disease;Automobile Driving;Biological Markers;Brain;Candidate Disease Gene;candidate identification;Cell Nucleus;cell type;Cells;cellular resilience;CRISPR library;Data;Dementia with Lewy Bodies;Development;dopaminergic neuron;Future;gene editing technology;Gene Expression Profiling;Genes;Goals;Guide RNA;Harvest;Human;in vivo;Injections;Investigation;Knowledge;Methods;Midbrain structure;Modeling;mouse model;Mus;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuron loss;neuronal survival;Neurons;neuroprotection;Parkinson's Dementia;Pathology;Patients;Pattern;Predisposition;preventive intervention;Process;Reporting;Research;resilience;response;RNA library;screening;single nucleus RNA-sequencing;Stress;stressor;synucleinopathy;System;Therapeutic;Therapeutic Intervention;transcriptome sequencing;transcriptomic profiling;Transgenic Organisms;Variant;Work

PROJECT_TITLE: A multiplexable in vivo perturbation toolkit to identify genes affecting neurodegeneration in a model of synucleinopathy


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: NARRATIVE On average, children from disadvantaged backgrounds, on average exhibit disparities in academic achievement and cognitive development, compared to their peers from higher socioeconomic status (SES) backgrounds. The proposed studies will investigate the role of specific aspects of children’s early language input on the development of neural networks supporting the development of language, executive functioning, and social cognition, and how these may ultimately drive SES differences in academic achievement. Findings from this work have the potential to inform maximally impactful interventions to reduce achievement gaps and improve cognitive outcomes for children from all backgrounds.

PI_NAMEs: ROMEO, RACHEL RENE (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: 3-Dimensional;Academic achievement;Achievement;Address;Administrative Supplement;Affect;Affective;Age;Auditory;Award;Behavioral Research;Biomedical Research;Brain;brain circuitry;Brain region;Child;Child Language;Code;Cognitive;cognitive development;cognitive skill;cognitive task;Complex;critical period;Development;Dimensions;disadvantaged background;Disparity;early experience;Environment;Environmental Risk Factor;executive function;Exhibits;experience;Exposure to;functional near infrared spectroscopy;Funding;Grant;Home;improved;Income;Inferior;innovation;Intervention;Investigation;Knowledge;Language;Language Development;Left;Linguistics;Link;low socioeconomic status;Magnetic Resonance Imaging;Measures;Mediating;Modeling;multimodality;National Institute of Child Health and Human Development;neural;neural circuit;neural network;Neurocognitive;neurodevelopment;neuromechanism;Nursery Schools;Outcome;Parent-Child Relations;peer;Phase;Play;Positioning Attribute;Preschool Child;Readiness;Research;research faculty;Research Project Grants;Role;scaffold;Schools;Semantics;Shapes;skills;social;social cognition;social factors;Socioeconomic Status;success;support network;syntax;System;Testing;therapy design;therapy development;Time;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Supplement for Continuity of Biomedical and Behavioral Research Among First-Time Recipients of NIH Research Project Grant Awards


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Digestive Diseases;Microbiome;Neurodegenerative;Neurosciences

ORG_CITY: MADISON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE__________________________________________________________________ Alzheimer’s disease is one of the most prevalent and impactful diseases in the United States and throughout the world. Currently no effective treatments or therapeutics that slow or stop Alzheimer’s disease are available. This project seeks to determine the mechanism by which changes in the gut microbiota and gut permeability can modify the pathogenesis of Alzheimer’s disease. The proposed work is expected to result in new information that can inform the development of new therapeutic strategies or treatments for Alzheimer’s disease.

PI_NAMEs: BENDLIN, BARBARA BRIGITTA (contact);REY, FEDERICO E;ULLAND, TYLER KENT

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Acceleration;Address;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Antibody titer measurement;Automobile Driving;Award;Biological Assay;Biological Markers;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Brain;Cerebrospinal Fluid;Chemicals;Circulation;Clinical;Cognitive;cohort;Collection;Dementia;Derivation procedure;Development;Disease;Disease Progression;effective therapy;experimental study;FRAP1 gene;Funding;Gastrointestinal tract structure;Germ-Free;glial activation;Gnotobiotic;Goals;gut dysbiosis;gut inflammation;gut microbes;gut microbiome;gut microbiota;Homeostasis;Human;Immune response;Immune system;Impairment;indexing;Individual;inflammatory marker;Infrastructure;Innate Immune Response;intestinal barrier;Intestinal permeability;Intestines;Lactulose;Leukocyte L1 Antigen Complex;Link;Lipopolysaccharides;Liquid substance;macromolecule;Mannitol;Measures;Mediating;metagenome;Methods;Microbe;microbial;Microbiology;microbiome composition;mouse model;Mucous body substance;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroimmunology;neuropathology;novel therapeutic intervention;older adult;Participant;participant enrollment;Pathogenesis;Pathology;Permeability;Persons;Play;Positron-Emission Tomography;Process;prospective;Publishing;Reporting;Research;Resources;Role;Sampling;Signal Transduction;Sodium Dextran Sulfate;stool sample;success;System;systemic inflammatory response;tau Proteins;Testing;Therapeutic;Time;United States;virtual;Wisconsin;Work

PROJECT_TITLE: Gut barrier function in Alzheimer's Disease


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: TUCSON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The goal of our Program is to elucidate the molecular mechanisms by which human cytomegalovirus (HCMV) recruits and controls host DNA damage responses to ensure the fidelity of the viral genome. Importantly, this work will define the mechanisms by which HCMV evolves antiviral resistance. Despite advances in diagnostics and therapeutics, HCMV remains a major life-threatening complication following solid organ or stem cell transplantation.

PI_NAMEs: BOSCO, GIOVANNI ;GOODRUM, FELICIA D (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Anti-viral resistance;Anti-viral Therapy;Biological Models;Biology;Bypass;Cells;Chromosome Fragile Sites;Complex;Complication;Cytomegalovirus;Data;Diagnostic;DNA biosynthesis;DNA Damage;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA-Directed DNA Polymerase;Double Stranded DNA Virus;Ensure;Evolution;Family;Ganciclovir;Genome;genome integrity;Genome Stability;Goals;Guanine + Cytosine Composition;Herpesviridae;Human;Infection;insight;Lesion;Life;Life Cycle Stages;Molecular;Nucleosides;Organ;Pathway interactions;Polymerase;programs;Publishing;recruit;Recruitment Activity;repaired;Resistance;response;Role;Single Nucleotide Polymorphism;Single-Stranded DNA;Solid;Stem cell transplant;Therapeutic;Viral;Viral Drug Resistance;Viral Genome;viral genomics;Viral Pathogenesis;virus host interaction;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Host DNA repair pathways in human cytomegalovirus replication

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Patient Safety;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Los Angeles

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Age is the major risk factor for most chronic human diseases, including Alzheimer’s disease. There is a vital need to develop new approaches to rejuvenate the brain and improve cognition. This research should provide important information that can be used to discover new anti-aging therapies.

PI_NAMEs: BONAGUIDI, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Adult;adult neurogenesis;Age;age related;age related changes;age related decline;Aging;aging hippocampus;aging related;Alzheimer's Disease;Animals;anti aging;behavioral study;Brain;Cell Aging;Cell division;Cell Reprogramming;Cells;Chemicals;Chromatin;Chronic;Cognition;cognitive reserve;Cytotoxic T-Lymphocytes;Data;Dementia;experimental study;Functional disorder;gain of function;Gene Expression;gene network;Genes;genetic signature;Goals;Health;human disease;Imatinib;improved;indexing;innovation;insight;Intervention;Learning;Lymphokines;Maps;Mediating;Memory;middle age;Molecular;nerve stem cell;neurogenesis;Neurons;novel strategies;old mice;overexpression;parent grant;Pharmacogenomics;Production;programs;Proliferating;Protein Kinase;Proteins;Regenerative capacity;Regenerative Medicine;Rejuvenation;Reporting;Research;resilience;restoration;Risk Factors;self-renewal;single-cell RNA sequencing;small molecule;stem cell aging;stem cell fate;stem cell function;stem cell proliferation;Sulindac Sulfone;Systems Biology;Techniques;Testing;Topoisomerase;Transcript;transcriptomics;validation studies;Work

PROJECT_TITLE: Neural stem cell rejuvenation through single cell pharmacogenomics


NIH_SPENDING_CATS: Clinical Research;Genetics;Lung;Organ Transplantation;Pulmonary Fibrosis;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Although telomere regions at the ends of human chromosomes normally shorten with age, accelerated shortening can lead to diseases like idiopathic pulmonary fibrosis (IPF) that may necessitate lung transplantation. This proposal tests the innovative hypothesis that accelerated telomere shortening may also cause loss of function in the transplanted lung. This novel paradigm could lead to novel diagnostics and interventions to improve survival following lung transplantation.

PI_NAMEs: GREENLAND, JOHN  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acceleration;Affect;Age;Allografting;alveolar epithelium;Award;Biopsy;Biopsy Specimen;Bronchiolitis;Cell Aging;Cells;Cessation of life;Characteristics;Chromosomes;Chronic;Clinical;Closure by clamp;cohort;Cohort Studies;Cox Models;Cox Proportional Hazards Models;Data;Development;Disease;Donor person;Donor Selection;Enrollment;Epithelial Cells;epithelial stem cell;Epithelium;Failure;fibrotic lung disease;Fluorescent in Situ Hybridization;Functional disorder;Genetic Crosses;Genetic Induction;Genetic Risk;genetic variant;Genetic Variation;Genotype;Germ Lines;graft dysfunction;Hand;Hilar;Human;Human Chromosomes;idiopathic pulmonary fibrosis;IL2RG gene;Immune;Immune response;Immunofluorescence Immunologic;Immunosuppression;Impairment;improved;improved outcome;Inflammation;Injury;innovation;Intervention;Investigation;Isogenic transplantation;Label;Length;Life;Link;Longitudinal cohort;loss of function;Lung;lung allograft;Lung Diseases;lung injury;Lung Transplantation;Lymphocyte;Measures;Mediating;Molecular;mouse model;Mus;novel;novel diagnostics;Nucleoproteins;Organ;Outcome;Pathogenesis;Pathologic;Pathology;Patient-Focused Outcomes;Patients;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;post-transplant;Predisposition;Proliferating;prospective;Pulmonary Surfactant-Associated Protein C;Rehabilitation therapy;Reperfusion Injury;response;Risk Assessment;Risk Factors;Role;Sampling;Secondary to;Solid;stem cells;telomere;Telomere Shortening;Testing;Therapeutic Intervention;Time;Tissues;Transplant Recipients;Transplantation

PROJECT_TITLE: Telomere Dysfunction as a cause of Chronic Lung Allograft Dysfunction

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Pediatric

ORG_CITY: DALLAS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Significance and Health Relevance of Proposed Studies The research described in this proposal will provide much-needed knowledge of postnatal brain development, and ultimately inform the design of future developmental interventions to ameliorate symptoms of neurological disorders.

PI_NAMEs: LIN, YINGXI  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Affect;Age;autism spectrum disorder;Behavioral;Brain;Brain imaging;Brain region;brain volume;Cells;cognitive function;Critical Pathways;Data;design;Development;Developmental Process;Environment;environmental enrichment for laboratory animals;epigenome;Event;Exhibits;experience;Future;gene regulatory network;Genetic;Genetic Transcription;Goals;Health;Heterogeneity;Image;Immediate-Early Genes;in vivo;Individual;Intervention;intervention effect;Knowledge;Label;Light;Maps;Methods;Modeling;Molecular;Monitor;Morphology;Mus;Nature;Nervous System Disorder;neural circuit;Neurodevelopmental Disorder;Neurons;NPAS4 gene;Output;Pathway interactions;Population;postnatal;postnatal period;Pregnancy;prenatal;Process;programs;Property;reduce symptoms;Reporter;Research;research study;spatiotemporal;Speed;Structure;Symptoms;Synapses;Therapeutic Intervention;Time;Tissues;tool;transcriptome;Valproic Acid

PROJECT_TITLE: Mechanisms Governing Activity-dependent Postnatal Brain Development

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

PHR: Significance and Health Relevance of Proposed Studies The research described in this proposal will shed new light on the synaptic and circuit mechanisms underlying memory discrimination and generalization, and may lead to new treatment strategies for neuropsychiatric disorders, such as PTSD and panic disorder, that are caused by the imbalance between memory discrimination and generalization.

PI_NAMEs: CASTILLO, PABLO E;LIN, YINGXI  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Adaptive Behaviors;Behavior;Behavioral;Brain;Brain-Derived Neurotrophic Factor;Cells;Data;dentate gyrus;Discrimination;Disease;Electrophysiology (science);entorhinal cortex;Equilibrium;experience;fear memory;Future;Gene Expression;Genetic Transcription;granule cell;Health;Individual;innovation;Interneurons;Lateral;Learning;Medial;Mediating;Memory;memory encoding;Modification;Molecular;Morphology;Neurons;neuropsychiatric disorder;novel;novel therapeutic intervention;NPAS4 gene;Output;Panic Disorder;Pathway interactions;Population;Post-Traumatic Stress Disorders;Process;recruit;Reporter;Research;research study;Role;Stimulus;Synapses;Synaptic plasticity;Time;transcriptome sequencing

PROJECT_TITLE: Activity-Dependent Transcriptional Pathways Underlying Synaptic Mechanisms for  Memory Discrimination and Generalization

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE  The project by Drs. Gage, Mertens and colleagues aims at deciphering the roles of neuronal hypo- maturity in Alzheimer’s disease (AD) using patient-specific 3D models. The team will study the spatial relationship between markers for neuronal senescence, neurodegeneration, maturation, and neuroinflammation in functional and unbiased multi-omic approaches employing AD and control derived 3D models. They will also leverage insights from the cancer field and explore chemical PKM modulators in AD patient 3D models to develop novel approaches to treat AD, and they will assess the impact of aberrant metabolic states of human neurons and astrocytes in the context of neuron-astrocyte coupling in a three-dimensional multicellular model. 1

PI_NAMEs: GAGE, FRED H (contact)

PROJECT_TERMS: 3-Dimensional;abeta deposition;Address;Adult;Affect;Age;age related;aged;Aging;aging related;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;anti-cancer research;Antineoplastic Agents;Apolipoprotein E;apolipoprotein E-4;Astrocytes;Autopsy;base editing;Biological Assay;Brain;Buffers;cancer cell;Cell Aging;Cell model;Cell Nucleus;cell type;Cells;Central Nervous System;Chemicals;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complement;Coupling;Cytoplasm;Data;Defect;Disease;Disease Marker;disease phenotype;Disease Progression;drug development;drug discovery;Effectiveness;Elderly;Environment;Epigenetic Process;Etiology;Exhibits;Gene Expression;Genes;Genetic;Goals;Haplotypes;Human;Impairment;Individual;Induced Neurons;induced pluripotent stem cell;Inflammation;Inflammatory;injured;insight;Knowledge;Lead;lipid metabolism;lipidomics;Macrophage;Malignant Neoplasms;Metabolic;metabolic abnormality assessment;Metabolism;metabolomics;Microglia;Mitochondria;Molecular;multiple omics;Natural Compound;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neuronal Dysfunction;Neurons;Neurosciences;novel strategies;Nuclear;Oncogenic;Onset of illness;Organoids;paracrine;Paraffin;pathogen;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Persons;Phosphorylation;postmitotic;programs;Property;Protein Isoforms;Proteins;Proteomics;Protocols documentation;Reaction;Rejuvenation;RNA Splicing;Role;Scientific Advances and Accomplishments;senescence;single-cell RNA sequencing;spatial relationship;Stimulus;Structure;Synapses;tau Proteins;Testing;Therapeutic;three-dimensional modeling;Tissues;Toxic effect;transcriptome;transcriptome sequencing;Transgenic Organisms;Variant;Warburg Effect

PROJECT_TITLE: Assessing cellular aging in old and rejuvenated neurons from Alzheimer patients


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: R01 Parent Project Narrative This project’s relevance to public health stems from its efforts to identify aspects of the bilingual experience that are associated with a significantly later age of symptom onset in Hispanics with language-prominent dementia. In addition, this project will address evidence-based treatment approaches for bilingual speakers with progressive language impairments caused by dementia (i.e., primary progressive aphasia). The project will enhance our knowledge of bilingualism as a contributor to cognitive reserve and brain plasticity which will inform theory and clinical practice in this historically underserved population.

PI_NAMEs: GRASSO, STEPHANIE M (contact)

PROJECT_TERMS: Age;Age of Onset;aging population;Alzheimer's disease related dementia;Attention;Behavior assessment;Behavioral;bilingualism;Brain;Brain region;clinical practice;Cognitive;cognitive reserve;cohort;Collaborations;Confounding Factors (Epidemiology);Dementia;Enrollment;Epidemic;Evidence based treatment;experience;Hispanic;Hispanic Populations;International;Intervention;Knowledge;Language;Language Development;language impairment;Learning;Life Experience;Linguistics;Literature;Magnetic Resonance Imaging;Measures;neural;neuromechanism;Outcome;parent project;Pattern;Primary Progressive Aphasia;Progressive Aphasias;Public Health;Rehabilitation therapy;Reporting;Research;resilience;social culture;Societies;Spanish;Speech;stem;Symptoms;Syndrome;theories;treatment optimization;treatment response;Underserved Population;Variant

PROJECT_TITLE: Bilingual Factors Associated with Cognitive Reserve and Linguistic Resilience in Hispanics with Primary Progressive Aphasia


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PI_NAMEs: GRAY, ELMER  (contact)

PROJECT_TERMS: Adult;Animal Model;Animals;Basic Science;Contracts;Development;Evaluation;Maintenance;Onchocerca volvulus;Simuliidae;Simulium genus

PROJECT_TITLE: Task C08: Maintenance of Black Fly (Simulium Vittatum IS-7) Immature and Adult Stages


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Patient Safety

ORG_CITY: PRINCETON

ORG_NAME: THERADEX SYSTEMS, INC.

ORG_STATE: NJ

PI_NAMEs: ANDERSON, BARRY  (contact)

PROJECT_TERMS: Adherence;Biological Assay;Biological Products;Cancer Center;Clinical Trials;Clinical Trials Network;Collaborations;Community Clinical Oncology Program;Conduct Clinical Trials;Contract Services;Data;data integrity;data management;Division of Cancer Treatment and Diagnosis;early phase clinical trial;Ensure;Funding;Funding Agency;Good Clinical Practice;good laboratory practice;Good Manufacturing Process;Guidelines;Institution;International;Investigational Therapies;Laboratories;manufacturing facility;Medidata;Monitor;Monitoring Clinical Trials;patient registry;Patients;Phase;Phase II Clinical Trials;Policies;Procedures;Process;Protocols documentation;quality assurance;Quality Control;Randomized;Regulation;Research;research and development;Resources;Services;Site;Site Visit;Support Contracts;symposium;System;United States Dept. of Health and Human Services;United States Food and Drug Administration;Visit

PROJECT_TITLE: CLINICAL TRIALS MONITORING SERVICE


NIH_SPENDING_CATS: Biotechnology;Cancer;Patient Safety

PROJECT_TITLE: CLINICAL TRIALS MONITORING SERVICE_ Moonshot support


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PROJECT_TITLE: FRAMINGHAM HEART STUDY - YEAR 5 EXAM


NIH_SPENDING_CATS: Biotechnology;Genetics;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: N/A, N/A  (contact)

PROJECT_TERMS: ABCA3 gene;alpha 1-Antitrypsin;biobank;Blood Vessels;BMPR2 gene;Boston;Cell Line;Cell Therapy;Cells;Clinical;Communities;Cystic Fibrosis Transmembrane Conductance Regulator;Development;disease model;Drug Screening;Ensure;Epithelium;Fluorochrome;Future;gene editing technology;Gene Mutation;Genes;Genetic;Human;Human Cloning;human induced pluripotent stem cells;Immune;In Vitro;Induced Mutation;induced pluripotent stem cell;interstitial cell;Knock-in;Lung;lung development;Lung Diseases;lung regeneration;Medical center;Methods;Mutation;National Heart, Lung, and Blood Institute;Organoids;Patients;personalized therapeutic;quality assurance;Regenerative Medicine;Reporter;Reporter Genes;Research;Research Personnel;Resources;Scientist;tool;Training Activity;Training and Education;Training Programs;Universities;Work

PROJECT_TITLE: NATIONAL BIOREPOSITORY OF LUNG DISEASE-SPECIFIC HUMAN INDUCED PLURIPOTENT STEM CELLS:THE PURPOSE OF THIS RESOURCE IS TO BUILD AND SUPPORT A CRITICAL


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Age-related cognitive dysfunction is linked to changes in functional brain network organization in humans.  The development of a lifespan mouse model of a functional connectome that directly parallels human  work will illuminate sources of risk and resilience to age-related decline, and provide a translational bridge  to evaluate the mechanisms of cognitive decline in both healthy and diseased aging.

PI_NAMEs: KAHN, ITAMAR  (contact);WIG, GAGAN S

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Adult;Advanced Development;Age;age related;age related decline;Age-associated memory impairment;age-related disease;Aging;aging brain;aging mechanism;aging related;aging related disease;Alzheimer's Disease;animal model development;Animals;Atrophic;awake;Behavior;Behavioral;Biological Assay;Brain;Brain imaging;Brain Pathology;cerebral atrophy;Cognition;Cognitive;cognitive change;Compensation;Complex;computerized tools;connectome;Data;Dementia;Development;Disease;executive function;Exhibits;functional loss;Functional Magnetic Resonance Imaging;Genetic;Graph;Health;healthy aging;Human;human imaging;human old age (65+);human subject;imaging approach;imaging system;Impaired cognition;Individual;insight;Intervention;Learning;Lesion;Life;life span;Link;Location;Measures;Memory;Modeling;Molecular;Motor;mouse model;Mus;Nerve Degeneration;non-invasive imaging;novel therapeutic intervention;pathological aging;Pathology;Pathway Analysis;Phenotype;Predisposition;Procedures;prognostic;Research;resilience;Rest;Risk;segregation;Sensory;Severities;sex;Source;support network;System;Testing;theories;Wakefulness;Wild Type Mouse;Work

PROJECT_TITLE: CRCNS: Assessing long-term impacts of disruption to large-scale brain networks


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Complementary and Integrative Health;Mental Health;Neurosciences;Pain Research;Sleep Research

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: RELEVANCE (See instructions): Understanding how the infraslow sigma power (ISP) rhythm regulates sleep architecture and REM sleep will help identify mechanistic targets to restore sleep quality impaired by stress, chronic pain, or affective disorders, thus providing substantial translational value for human health. As the ISP rhythm is present in the human EEG, it is a potential biomarker for assessing sleep quality and may enable the early detection of sleep disturbances, which are often precursors for other disorders. In addition, our findings will unravel neural mechanisms that promote infraslow brain dynamics and may thus open new avenues to develop complementary approaches that can amplify the ISP rhythm and thereby enhance the restorative effects of high-quality sleep on brain homeostasis and mental health.

PI_NAMEs: BEHN, CECILIA DINIZ;BOOTH, VICTORIA ;WEBER, FRANZ L (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Affect;Area;Behavioral;Biophysics;Brain;Brain Stem;cerebrospinal fluid flow;Chronic Disease;chronic painful condition;Complementary Health;Computer Models;Control Locus;Coupled;Coupling;Data;Development;Disease;Dorsal;Early Diagnosis;Electroencephalography;Exhibits;experimental study;Feedback;Frequencies;Generations;glymphatic system;Health;Heart Rate;Homeostasis;Human;Impairment;improvement on sleep;Instruction;Integrative Medicine;Link;locus ceruleus structure;Mental Health;midbrain central gray substance;Modeling;Mood Disorders;Mus;Network-based;neural;neurofeedback;neuromechanism;Neurons;non rapid eye movement;Norepinephrine;optogenetics;Pain;Pain Disorder;Periodicity;Physiological;Play;potential biomarker;predictive modeling;pressure;Process;Property;Psychological Stress;rapid eye movement;REM Sleep;REM Sleep Deprivations;response;Role;Shapes;Sleep;Sleep Architecture;Sleep disturbances;sleep quality;sleep regulation;Source;Stress;stress disorder;synergism;Testing;Variant;vasomotion;wasting;Well in self;Work

PROJECT_TITLE: CRCNS: Mechanisms and consequences of infraslow oscillations in sleep


ORG_NAME: CHILD MIND INSTITUTE, INC.

PHR: RELEVANCE (See instructions): The 3D reconstructed receptor atlas in humans, nonhuman primates, and rodents generated through this proposal will set a benchmark for translational neuroscience. This leap will deepen our understanding of the neurobiological bases of brain psychiatric disorders and accelerate the basic and translational research required for drug development using animal models.

PI_NAMEs: XU, TING  (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Algorithms;Animal Model;Architecture;Atlases;Autoradiography;Basic Science;Benchmarking;Brain;brain based;Brain Diseases;Brain region;Callithrix;cognitive function;Communication;Communities;Comparative Study;Complex;computer framework;Coupling;Data;data exchange;data resource;drug development;Evolution;flexibility;Fostering;Functional Magnetic Resonance Imaging;Future;Germany;Goals;Graph;Human;improved;innovation;insight;Instruction;interdisciplinary collaboration;Intuition;Joints;Link;Macaca;Magnetic Resonance Imaging;Maps;Mental disorders;Modeling;Molecular;multimodality;Neocortex;neural;neural network;Neurobiology;neurochemistry;neuroregulation;Neurosciences;Neurotransmitter Receptor;Neurotransmitters;nonhuman primate;novel;Outcome;Pattern;Phylogenetic Analysis;Play;Primates;Rattus;receptor;Resolution;Rodent;Role;Sensory;spatiotemporal;Structure;System;Techniques;Testing;tool;transfer learning;translational neuroscience;Translational Research;translational study;Travel;Variant;Work

PROJECT_TITLE: CRCNS: Linking receptorarchitecture and functional brain  networks across species


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: RELEVANCE (See instructions): Our work is most relevant to Objective 1.1, Strategy 1.1B of the NIMH strategic plan, aiming to reveal the mechanisms underlying action potential propagation in central nervous system and how this is disrupted in neurological conditions like depression. In particular, we will elucidate the biophysical factors affecting neuronal communication and develop theoretical models that predict changes in neuronal outputs based on neuronal morphology or even osmolarity in cerebrospinal fluid.

PI_NAMEs: RANGAMANI, PADMINI  (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: Actins;Action Potentials;Affect;Aftercare;Age;Aging;Axon;Biological;biophysical model;biophysical properties;Biophysics;Brain;Cell membrane;Cell Physiology;Cell Shape;Cellular Morphology;Central Nervous System;Cerebrospinal Fluid;Communication;Computer Models;Coupled;Coupling;Cytoskeletal Modeling;Cytoskeleton;Data;Development;Diameter;Disease;Electron Microscopy;Electrons;Epilepsy;Exhibits;experience;experimental study;Extracellular Space;Freezing;Geometry;Goals;Health;Hippocampus;Huntington Disease;in silico;In Vitro;insight;Instruction;Integral Membrane Protein;Ions;Ischemia;Length;Lipid Bilayers;Lipids;Mathematics;Measurement;mechanical force;mechanical properties;mechanical signal;Mechanics;Membrane;Mental Depression;microscopic imaging;model development;Modeling;Modulus;Morphology;Mus;National Institute of Mental Health;Nature;Nerve Degeneration;Nervous System Disorder;Neurologic;neuron loss;Neuronal Dysfunction;neuronal excitability;Neurons;Organelles;Osmolar Concentration;Osmosis;Output;Periodicity;pharmacologic;Physiological;Play;Potassium Channel;predictive modeling;preservation;pressure;Property;response;Role;Shapes;Signal Transduction;simulation;Slice;Sodium Channel;Speed;Strategic Planning;Structure;Synapses;Synaptic Transmission;Techniques;Testing;Theoretical model;theories;Thinness;trafficking;Tube;Variant;Varicosity;Visualization;voltage;Work

PROJECT_TITLE: CRCNS: Biophysical modeling of axonal morphology and function


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: This project will develop sustainable aging research infrastructure, a new and unique genetically heterogeneous laboratory rat model (OKC-HETb/w) that can be use evaluating putative life- and health-extending interventions. This model was designed to give maximum genetic diversity in both the nuclear and mitochondria genomes. The lifespan and age-related pathology in the OKC-HETb/w rat will be determine, and the effect of 17α-estradiol on the lifespan evaluated.

PI_NAMEs: AUSTAD, STEVEN N.;RICHARDSON, ARLAN G. (contact);STOUT, MICHAEL B

PROGRAM_OFFICER_NAME: MORO, MANUEL H

PROJECT_TERMS: African;age related changes;Age related pathologies;Aging;aging mechanism;aging process;Alzheimer's Disease;Animals;anti aging;Biological Assay;Biology;Blood;blood glucose regulation;bone;Breeding;Cancer Intervention;Clinic;Code;Cognitive;cognitive capacity;Data;design;diet-induced obesity;Dose;endurance exercise;Estradiol;Fatty Liver;Female;Functional disorder;Genes;Genetic;Genetic Variation;Genomics;Genotype;Goals;Hand Strength;Health;Human;Human Biology;Hybrids;improved;Inbred Strain;Inbreeding;insulin sensitivity;inter-institutional;Intervention;Intervention Studies;Laboratory Rat;Life;life span;Long-Term Effects;Longevity;male;Metabolic;metabolic abnormality assessment;Mitochondria;mitochondrial genome;Mitochondrial Proteins;Modeling;Monkeys;Mothers;mouse model;Mouse Strains;Mus;Muscle;Norway;novel;Nuclear;Nucleotides;Obese Mice;Outcome;Pharmaceutical Preparations;pharmacologic;Phase;Physiological;Physiology;Plasma;Population;programs;Proteins;Rattus;Research;Research Infrastructure;Research Personnel;Ribosomes;Scheme;sex;Sex Differences;Site;Specificity;Standardization;Stress;Supplementation;Testing;therapy development;Time;Tissues;Transfer RNA;Translating;translation to humans

PROJECT_TITLE: A New Translational Rat Model for Evaluating Anti-Aging Interventions


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: By quantitatively characterizing how neurons in the auditory cortex learn to encode behaviorally relevant complex sounds such as vocalizations, this project will reveal fundamental principles of the organization and function of auditory cortical circuits for sensory aspects of vocal communication across species. By gaining a deeper understanding of the normal function of these circuits, our project could also provide insight into circuit dysfunction underlying communication disorders.

PI_NAMEs: SADAGOPAN, SRIVATSUN  (contact);ZHOU, YI

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TITLE: CRCNS: Conserved neural computations underlying communication sound recognition in rodents and primates


NIH_SPENDING_CATS: Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Data Science;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

PHR: RELEVANCE (See instructions): Millions of people are affected by communication and language processing disorders. This research aims  to develop new machine-learning models to analyze typical and atypical language patterns using neural  responses recorded during real-life conversations. The goal is to create targeted interventions for people  with speech and language disabilities and develop tools to support individuals with communication  disorders, including aphasia, dysarthria, or stuttering.

PI_NAMEs: HASSON, URI  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Acoustics;adjudication;Affect;Aphasia;autism spectrum disorder;Brain;Code;Collection;Communication;Communication impairment;Complex;Computer Models;Data;Data Set;design;Disease;Dysarthria;Electrocorticogram;Epilepsy;expectation;Family;Future;Goals;hearing impairment;Hour;Human;improved;Individual;information model;insight;Instruction;Intervention;Knowledge;Language;Language disability;language impairment;language processing;large language model;Life;Linguistics;machine learning model;Maps;Medical Staff;Modeling;natural flow;Natural Language Processing;neural;neural model;neural patterning;neuromechanism;novel;patient engagement;patient-clinician communication;Patients;Pattern;Persons;predictive modeling;Probability;Process;Production;programs;Research;response;Signal Transduction;social communication;social deficits;specific language impairment;Speech;Structure;Stuttering;Testing;theories;Thinking;tool;transmission process;Variant

PROJECT_TITLE: CRCNS: Building and testing computational models of the neural basis of natural communication


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: RELEVANCE (See instructions): The results will provide a validated model that can explain individual and clinical differences across tasks  and will reveal biological changes that contribute to belief updating behavior, both normal and abnormal in  schizophrenia. This will not only define the neural mechanisms underlying complex and varying behaviors  (NIMH strategic plan goal 1), but likely also shed light on possible therapeutic targets for delusions (NIMH  strategic plan goal 3).

PI_NAMEs: NASSAR, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TITLE: CRCNS: Investigating the Neurocomputational Mechanisms of Belief Updating


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Schizophrenia

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: public health relevance, the circuit and computational principles underlying cognitive  flexibility are poorly understood. The prefrontal cortex (PFC) and mediodorsal (MD) thalamus play a  critical role in cognitive flexibility, disrupted PFC or MD activity or their temporal coordination may lead to  impaired flexibility in attentional control, working memory and decision making. Guided by the converging  evidence from the literature and our own preliminary data, we propose that temporal coordination between  the MD and PFC in the beta/gamma range enable optimal cognitive control, and that their perturbation  underlies some of the cognitive deficits in schizophrenia. We will develop experimental and computational  tools that further clarify this link along with a set of interventional tools that may ultimately be deployed in  human patients. Our central hypothesis is that temporal coordination of the MD and PFC neural activity  (spikes and local field potentials) provides a readout of animal's "state-of-mind" during working memory,  and that temporally patterned MD neurostimulation provides an effective strategy to enhance prefrontal  engagement in cognitive processing. Specifically, we will combine multidisciplinary techniques (genetic  mouse model, animal behaviors, multisite electrophysiology, optogenetics, closed-loop brain-machine  interface, machine learning and computational psychiatry) to understand temporal dynamics of  coordinated MD-PFC neural activity during flexible cognition tasks for both schizophrenic and wild-type  mouse models. In Aim 1, we will test the hypothesis that MD-PFC oscillatory entrainment deficits co-vary  with task-switching impairments in a high-penetrance genetic model relevant to schizophrenia. In Aim 2,  we will develop closed-loop patterned stimulation strategies to modulate MD-PFC circuits for improving  cognition. In Aim 3, we will develop spiking recurrent neural network models as a general platform for  prototyping interventions in the MD-PFC loop for cognitive dysfunction. Accomplishment of these aims is  highly significant for gaining translational insight into a wide range of neuropsychiatric disorders related to  cognitive dysfunction.

PI_NAMEs: CHEN, ZHE SAGE (contact);HALASSA, MICHAEL M

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: 22q11;Animal Behavior;Animals;Attention;attentional control;Behavior;Behavioral;Biological;brain machine interface;cell type;Characteristics;Cognition;Cognitive;cognitive control;Cognitive deficits;cognitive function;Collaborations;computational neuroscience;Computer Models;computerized tools;Data;Data Analyses;Decision Making;Development;Disease;Disparate;Dissection;DNA Sequence Alteration;efficacy study;Electrophysiology (science);Environment;Equilibrium;Esthesia;executive function;experimental study;flexibility;Foundations;Frequencies;Functional disorder;Genetic;Genetic Models;Human;Impaired cognition;Impairment;improved;innovation;insight;Instruction;Interneurons;Intervention;Joints;Knowledge;Lead;Link;Literature;Machine Learning;Mental disorders;Mind;Modeling;Molecular;mouse model;multidisciplinary;Mus;neural;neural network;Neural Network Simulation;Neurons;neuropsychiatric disorder;neuroregulation;optogenetics;Pathway interactions;Patients;Pattern;Penetrance;Performance;Phase;Phenotype;Play;Prefrontal Cortex;Primates;prototype;Psyche structure;Psychiatry;public health relevance;Publications;Publishing;Recording of previous events;recurrent neural network;Rodent;Role;Schizophrenia;schizophrenia risk;Sensory;Short-Term Memory;Site;Solid;Structure;success;Symptoms;Techniques;Testing;Thalamic structure;therapeutic target;therapeutically effective;therapy development;Thinking;tool;treatment strategy;Wild Type Mouse;Work

PROJECT_TITLE: CRCNS: Dissection and control of cognitive thalamocortical dynamics


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE  As the number of older adults continues to rise, and the prevalence of individuals affected by neurodegenerative disease increases, understanding the interpersonal factors that contribute to caregivers’ health decline will become increasingly important. Identifying interpersonal mechanisms that promote or hinder caregivers’ health will point towards potentially modifiable factors that could reduce the collateral damage of neurodegenerative disease. Findings from the current research could facilitate the development of targeted and effective interventions to maintain the health of caregivers and the individuals for whom they care.

PI_NAMEs: BROWN, CASEY LEIGH (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acute;adverse outcome;Affect;Aging;Alzheimer's Disease;archived data;Area;Atrophic;Behavior;Behavioral;behavioral variant frontotemporal dementia;Biological Markers;Blood;Brain region;California;care recipients;career;Caregiver well-being;Caregivers;caregiving;Caring;Characteristics;Cognitive;Collection;comparison control;Conflict (Psychology);Critical Pathways;Cues;Data Collection;Development;Disease;effective intervention;emotion regulation;Emotional;emotional stimulus;Emotions;Empathy;Environment;Equation;experience;Face;flexibility;Functional impairment;Goals;Growth;Health;Health Psychology;Impairment;indexing;Individual;Laboratories;late life;Lead;Light;Link;loved ones;Measurement;Medial;Memory;Mental Health;Mentorship;Modeling;negative affect;neural;Neurodegenerative Disorders;neuroimaging;older adult;Outcome;Pathway interactions;Personal Satisfaction;Persons;physical conditioning;positive emotional state;Prevalence;Process;Psychology;Reporting;Research;respiratory;response;San Francisco;showing emotion;Sinus Arrhythmia;skills;Social Network;Social support;Spouse Caregiver;Statistical Models;Stress;stressor;Techniques;Technology;theories;Time;Training;Universities;Visual attention;visual tracking

PROJECT_TITLE: Interpersonal Emotion Regulation in Neurodegenerative Disease: Pathways to Caregiver Health


ADMINISTERING_IC: TR

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: San Diego

ORG_NAME: EMBRIENT INC

PHR: Narrative Embrient Inc is pleased to submit our request for an HHS / SBIR / NIBIB grant, entitled, “Developing a Novel Incubator to Increase Cell Culture Reproducibility.” By funding this grant, you will support our efforts to design and test an incubator that employs laminar flow principles, aiming to achieve zero or near-zero chamber recovery time when the incubator door is opened. This innovation holds the promise that future cell culture experiments utilizing our incubator can maintain stable conditions akin to the human body, without the extensive fluctuations that affect the reliability of current market incubators. As a result, research outcomes will be more dependable and reproducible, advancing scientific progress.

PI_NAMEs: ROTHENBERG, BARRY E. (contact)

PROGRAM_OFFICER_NAME: HAPPEL, CHRISTINE MARIE

PROJECT_TERMS: Address;Affect;Air;Air Movements;Algorithms;Atmosphere;Carbon Dioxide;Cell Culture Techniques;cell growth;Cells;commercial application;cost estimate;Data Collection;design;Development;Diffusion;Environment;experimental study;Flying body movement;Funding;Future;Gases;Grant;Health;HIV;Human body;Humidity;Hypoxia Inducible Factor;improved;Incubated;Incubators;innovation;Laboratories;Left;Legal patent;Liquid substance;Literature;Machine Learning;Maintenance;Malaria;Manufacturer;Marketing;Measures;Modernization;Molecular Biology;National Institute of Biomedical Imaging and Bioengineering;Nobel Prize;novel;novel therapeutics;Outcome;Outcomes Research;Phase;Recording of previous events;Recovery;Refrigeration;Reliability of Results;Reporting;Reproducibility;Reproducibility of Results;Research;Research Personnel;Scientific Advances and Accomplishments;seal;Secure;sensor;Shapes;simulation;Small Business Innovation Research Grant;System;Technology;Testing;Time;tool;United States National Institutes of Health;user-friendly;virtual


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Complementary and Integrative Health;Data Science;Genetics;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: CHAMPAIGN

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: RELEVANCE (See instructions): Resiliency to stress is crucial to the health of individuals and of society, but there remains a critical knowledge gap regarding the mechanisms underlying resilience to adverse outcomes. Stress resiliency is a complex phenomenon that arises from interactions across neural subsystems that span molecules to whole-brain connectivity, and how resilient individuals tap into these systems to maintain normal behavioral function is not fully understood. To address this gap, we propose to collect multimodal data at

PI_NAMEs: ZHAO, SIHAI DAVE (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Address;adverse outcome;Animal Model;Animals;Behavioral;behavioral phenotyping;Biological;Biological Assay;Biological Markers;biological systems;Brain;Chronic;Chronic stress;Complex;computerized tools;connectome;Data;data modalities;decrease resilience;density;Development;Electrophysiology (science);experience;experimental study;Exposure to;Gene Expression;Genes;Genetic;Genomics;Health;high dimensionality;Human;Inbred BALB C Mice;Individual;innovation;insight;Instruction;interdisciplinary approach;Joints;Knowledge;Machine Learning;machine learning method;Magnetic Resonance Imaging;Mental disorders;Modality;Modeling;Modernization;Molecular;mouse model;Mouse Strains;multidimensional data;multimodal data;multimodality;Mus;Nervous System;neural;neural circuit;Neuroanatomy;Neurobiology;neuroimaging;neuromechanism;Neurosecretory Systems;Pattern;Play;Predisposition;Prevalence;Productivity;resilience;response;Role;severe mental illness;signal processing;Signal Transduction;social;social defeat;Societies;Specificity;statistical and machine learning;Stress;stress resilience;System;Technical Expertise;Time;tool;transcriptome;transcriptome sequencing;Trauma;Validity of Results;vector

PROJECT_TITLE: CRCNS: Multimodal network interactions for internal state dynamics of resiliency


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Eye Disease and Disorders of Vision;Pediatric;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: We proposed to use postnatal mouse pups as a model for pediatric eye research to study the eﬀects of direct ocular exposure to vesicants in children.

PI_NAMEs: GORBATYUK, MARINA  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TITLE: Postnatal Mice as a Pediatric Research Model for Investigating Direct Ocular Exposure to Vesicants


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: RELEVANCE (See instructions): Alzheimer's disease (AD) is the 7th leading cause of death in the US and approaches for reducing the  number of people affected by dementia are needed. Studies show that the gut microbiome may play a role  in pathogenesis of AD. This project will use machine learning to understand the role of the gut microbiome  in AD development. Insights and software from this project are expected to inform the development of new  therapies for AD and improve the well-being of aging Americans.

PI_NAMEs: BENDLIN, BARBARA BRIGITTA;REY, FEDERICO E;SINGH, VIKAS  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: 3-Dimensional;Affect;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer's disease therapy;American;Architecture;Area;attenuation;Bacteria;base;Behavior;Biological Markers;Brain;brain health;Brain imaging;Cause of Death;Cerebrospinal Fluid;Clinical;cluster computing;Code;Cognition;Cognitive;cognitive testing;cohort;Communities;Computer software;Data;Data Set;Dementia;design;Development;effectiveness evaluation;Eye;Financial cost;flexibility;Future;generative models;Genes;gut microbiome;Health;high reward;Human;human old age (65+);Image;Impaired cognition;improved;Individual;Inherited;insight;Instruction;Investigation;Knowledge;large language model;large-scale imaging data;Learning;Liquid substance;Literature;Machine Learning;Measurement;Measures;Methods;Microbe;microbiome;microbiome analysis;microbiome composition;model generalizability;Modeling;modifiable risk;multimodal data;multimodality;Neurodegenerative Disorders;neuroimaging;novel;novel therapeutics;Pathogenesis;Pathology;Pattern;Performance;Personal Satisfaction;Persons;Pharmaceutical Preparations;Plasma;Population;pre-trained model;pre-trained transformer;prevent;Process;Research;Rewards;Risk Factors;Role;Sample Size;Software Tools;Structure;synthetic data;Taxonomy;Technology;Testing;Time;tool;Training;Work

PROJECT_TITLE: CRCNS: Repurposing Transformers to Characterize Gut Microbiome & Aging Brain Axis


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PI_NAMEs: BURTT, NOEL P;FLANNICK, JASON  (contact);GAULTON, KYLE JEFFRIE

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: Address;Big Data;bioinformatics pipeline;Biological;Biological Models;Biology;Biomedical Research;cell type;cloud based;Communities;computer scientist;Computer software;Coupled;Data;data ecosystem;Data Provenance;data quality;data resource;Data Set;Data Sources;data to knowledge;design;Disease;diverse data;Education and Outreach;Educational process of instructing;Engineering;Ensure;experience;Foundations;Funding;Generations;Genes;Genetic;genome resource;genomic data;Graph;information organization;Infrastructure;Knowledge;knowledge curation;Knowledge Extraction;knowledge graph;knowledge network;knowledge of results;Knowledge Portal;Libraries;Manuals;Maps;Metabolic Diseases;Methods;Modeling;National Center for Advancing Translational Sciences;National Human Genome Research Institute;National Institute of Diabetes and Digestive and Kidney Diseases;novel;outreach;Persons;preference;Procedures;Property;Provider;Regulatory Element;Research Personnel;Resources;Science;Scientist;Secure;Services;Statistical Computing;Testing;Thinking;tool;Training;Trust;Uncertainty;United States National Institutes of Health;user-friendly;Variant;Visualization;web portal;Work;working group

PROJECT_TITLE: The Common Fund Knowledge Center (CFKC): providing scientifically valid knowledge from the Common Fund Data Ecosystem to a diverse biomedical research community.

STUDY_SECTION: CFOT

STUDY_SECTION_NAME: Common Fund Other Transactions Programs[CFOT]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Rehabilitation

ORG_CITY: CHICAGO

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The number of individuals with disabilities and the extent of the disabilities continue to increase with a clear impact on the need for developing better and more effective rehabilitation interventions. The proposed pre- and post-doctoral program will train rehabilitation scientists based on solid fundamental science principles combined with engineering methods to allow them to establish successful research programs that translate into effective rehabilitation interventions and more importantly, are transferred to the clinic.

PI_NAMEs: HECKMAN, CHARLES  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TITLE: Research Training in Sensorimotor Neurorehabilitation


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PI_NAMEs: MOORE, JOHN P (contact)

PROGRAM_OFFICER_NAME: CHAKRABARTI, BIMAL KUMAR


NIH_SPENDING_CATS: Infectious Diseases;Lymphatic Research;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN DIEGO

ORG_NAME: BIG EYE DIAGNOSTICS, INC.

PHR: PROJECT NARRATIVE Here we propose a rapid, field-deployable, cost-effective, highly sensitive and specific lateral flow assay (LFA) that will fully meet a Target Product Profile (TPP) released in 2021 by the World Health Organization (WHO) for the surveillance of Lymphatic Filariasis (LF). The filarial worm Wuchereria bancrofti, the main causative pathogen of lymphatic filariasis (LF), has been the focus of the most ambitious mass drug administration (MDA) programs ever implemented by WHO. With 50 countries theoretically approaching disease elimination in the next 5 years, there is an urgent need for new and sensitive field-deployable diagnostics that will assist countries in conducting post-MDA surveillance until 2030, and beyond. The key requirements of the TPP are that the test should be able to detect early infection, have >85% clinical sensitivity and > 98.8% specificity, and be field-deployable and cost-effective. To date, the best markers of early infection are IgG4 antibodies the human host generates in response to Wb123, a protein expressed by the infective (L3) stage of W. bancrofti. The only existing IgG4/Wb123 portable Rapid Diagnostic Test (RDT), marketed by Abbott, had a clinical sensitivity around ¼ that of the corresponding ELISA. In earlier work, we have developed a prototype LFA for the detection of Wb123-specific IgG4 characterized by an analytical sensitivity 16-32 greater than that of the Abbott RDT and equal to the commercial Wb123 ELISA. This test is poised to meet the > 85% clinical sensitivity criterion but might fall short of the minimal (>98.8%) or ideal (>99.8%) specificity criterion. We now propose a biplex test allowing to simultaneously detect antibodies against two antigens, of which one will be Wb123, and the other one chosen from a series of five novel antigens, termed WbAg1-5 or WbAgX. The purpose of the dual test is to achieve a superior specificity by imposing the condition that both test lines must be visible to count the test as positive. We have been awarded a grant from the Task Force for Global Health (TFGH) and USAID to develop a prototype version of such a biplex assay. We are now requesting additional funding from the NIH to: (1) optimize the biplex assays (2) establish a biorepository of 2000 clinical samples and ensure that one biplex meets the WHO TPP with greater than 95% statistical confidence and (3) progress the selected biplex to manufacturing and commercialization. By the end of this Phase 1/2 Fast-Track grant, a total of 100,000 assays will be available for testing by the TFGH, the CDC, and other stakeholders to generate the field data necessary to secure its international endorsement.

PI_NAMEs: BIAMONTE, MARCO ANTONIO (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Achievement;Address;Advisory Committees;Affect;Aftercare;Antibodies;antibody detection;Antigens;Award;Benchmarking;biobank;Biological Assay;Biological Markers;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Sensitivity;Collaborations;combat;commercialization;Communities;cost;cost effective;Country;Data;design;Detection;detection assay;Devices;Diagnostic;Diagnostic tests;Disease;disease diagnostic;Early Diagnosis;Ensure;Enzyme-Linked Immunosorbent Assay;Exposure to;Filaria bancrofti;Filarial Elephantiases;Filariasis;Freezing;Funding;global health;Grant;Human;IgG4;Immunoglobulin G;improved;Infection;interest;International;Investments;Larva;lateral flow assay;Life;London;Low Prevalence;manufacture;manufacturing process;Marketing;Medical Device;National Institute of Allergy and Infectious Disease;neglected tropical diseases;novel;novel diagnostics;Parasites;pathogen;Performance;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phase;portability;Procedures;programs;Proteins;prototype;Publishing;Rapid diagnostics;rapid test;Recommendation;Recrudescences;repository;Research;response;Sampling;Secure;Sensitivity and Specificity;Series;Specificity;Speed;Stress Tests;Surveys;test strip;Testing;Time;transmission process;Tropical Climate;United States National Institutes of Health;USAID;volunteer;Work;World Health Organization

PROJECT_TITLE: Ultrasensitive, High-Specificity Rapid Test to Support the End-Game of the Global Program to Eliminate Lymphatic Filariasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(13)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Contraception/Reproduction;Endocrine Disruptors;Estrogen;Infertility;Women's Health Research

ORG_CITY: NEWARK

ORG_NAME: NEW JERSEY INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Exposure to endocrine disrupting chemicals such as phthalates contributes to increased rates of human infertility and reproductive disorders worldwide. The proposed research will fill a public health need by developing a method to investigate the mechanisms through which endocrine disrupting chemicals such as phthalates act to cause toxicity in the ovary. The results of this project will facilitate the development of safer alternative chemicals and contribute to the identification of new treatments to protect the ovary from environmental chemical exposure.

PI_NAMEs: WARNER, GENOA R (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Acceleration;Affinity;Award;Behavior;Biochemical;Biological;Biology;building materials;career;career development;Cell Culture Techniques;Cell membrane;cell type;Cells;Cessation of life;Chemical Structure;Chemicals;Chemistry;Child;chromatin immunoprecipitation;Complex;consumer product;Culture Media;Data;Development;Development Plans;Dioxins;Disease;DNA-Binding Proteins;Endocrine disruption;Endocrine Disruptors;Environment;environmental chemical exposure;Environmental Health;Enzymes;Equipment;Esters;exposed human population;Exposure to;Family;Female;Female infertility;Gene Expression;General Population;Genes;Genetic Transcription;Genomics;Goals;Hormones;Human;Hydrocarbons;Illinois;Image;imaging modality;In Vitro;Individual;Industrialization;Infertility;innovation;insight;Label;Length;lipophilicity;Mass Spectrum Analysis;Massive Parallel Sequencing;Mediating;Medical;men;Mentors;Mentorship;Metabolism;Methods;Modernization;Molecular;mouse model;Nature;novel;Oocytes;Ovarian;Ovarian aging;Ovarian Follicle;Ovarian Tissue;Ovary;ovotoxicity;personal care products;Phase;phthalates;Phthalic Acids;Plasticizers;Population;Postdoctoral Fellow;Premature Ovarian Failure;Prevalence;Prevention;programs;Property;Proteins;Public Health;receptor;Reproduction;reproductive;Reproductive Biology;reproductive organ;reproductive system disorder;Research;Research Personnel;Research Proposals;Research Training;Sampling;screening;Side;skills;small molecule;Solvents;Structure;Techniques;Technology;Testing;Tissues;Toxic effect;toxicant;Toxicology;Toy;Training;transcription factor;Universities;Urine;Visualization;Woman

PROJECT_TITLE: Mechanisms of Phthalate Toxicity in the Ovary

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Opioid Misuse and Addiction;Opioids;Serious Mental Illness;Substance Misuse

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Despite the prevalence of co-occurring psychiatric and/or substance use disorders in people living with HIV, these disorders are generally investigated in isolation, with very little work performed at the intersection of these disorders, especially in human brain. To address this gap, we propose to directly investigate the cellular and molecular mechanisms of co-occurring major depressive disorder, opioid use disorder, and HIV using a combination of multi-omics and histological approaches in postmortem human brain. These studies will improve our understanding of disease-related mechanisms in the brain, while paving the way for improving on current and new therapies.

PI_NAMEs: LOGAN, RYAN W (contact);SENEY, MARIANNE L

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: acquired factor;Address;Anhedonia;Anterior;Area;artificial neural network;ATAC-seq;Autopsy;Behavioral;behavioral response;Brain;brain tissue;Cell Nucleus;cell type;Chromatin;chromatin remodeling;Chromatin Structure;cingulate cortex;Clinical;clinically relevant;Cognitive;cohort;comorbidity;Complex;Conflict (Psychology);Decision Making;Dendritic Spines;density;Depressive disorder;design;Diagnosis;Disease;emotion dysregulation;emotion regulation;Emotional;Epigenetic Process;epigenomics;Excision;Exhibits;frontal lobe;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;genome wide association study;Health;Histologic;HIV;Human;Human Genetics;Human Genome;Image;Immunohistochemistry;Impaired cognition;improved;Individual;Inflammation;Inflammatory;innovation;Investigation;Major Depressive Disorder;Mental disorders;Microglia;Modeling;Molecular;Moods;Motivation;multiple omics;neural;neural correlate;Neuroimmunomodulation;neuroinflammation;novel therapeutics;opioid use disorder;Pathologic;Pathology;Pathway interactions;Persons;Pharmaceutical Preparations;Population;Prevalence;programs;psychosocial;Reporting;resilience;reward anticipation;Risk;Risk Factors;risk variant;Role;Signal Transduction;single cell sequencing;single nucleus RNA-sequencing;Stress;stress resilience;stress state;stressor;substance use;Substance Use Disorder;Synapses;Technology;therapy development;trait;Transcript;Transcription Alteration;Transcriptional Regulation;transmission process;Vertebral column;Viral Load result;Virus;Work

PROJECT_TITLE: Neuroimmune mechanisms involved in the complex co-morbidity Involving OUD, MDD, and HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]