NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative Laser interstitial thermotherapy (LITT) is an emerging minimally invasive technique for treatment of glioblastoma (rGBM), which is a common primary brain tumor associated with an extremely dismal prognosis. However, existing LITT devices can only ablate tissue around the tip of a fixed laser probe and are thus inadequate for large, irregularly shaped, and multifocal tumors. To achieve conformal tumor ablation, this project proposes a steerable laser interstitial thermotherapy (SLIT) robot that can navigate a brain tumor along multiple trajectories and ablate tumor tissue at multiple locations under intra-operative MR guidance.

PI_NAMEs: SHENG, JUN  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Ablation;Adjuvant;Agar;Air;Algorithms;Animal Model;Animals;Applications Grants;Brain;Brain Neoplasms;clinically relevant;Computer software;Cranial Irradiation;Custom;design;Development;Devices;Diagnosis;effective therapy;Ensure;Evaluation;Family suidae;FDA approved;Fiber;flexibility;Future;Gadolinium;Glioblastoma;Goals;graphical user interface;improved;In Vitro;in vivo;Induced Hyperthermia;interstitial;kinematics;Lasers;Lesion;Location;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Mechanics;minimally invasive;Modality;Modeling;Morphology;Motion;multidisciplinary;Neoplasm Metastasis;neuropathology;neurosurgery;Neurosurgical Procedures;novel;Operative Surgical Procedures;Organ;Outcome;Patients;Peripheral;phantom model;Pharmaceutical Preparations;porcine model;pre-clinical;prevent;Primary Brain Neoplasms;Procedures;Prognosis;Protocols documentation;Radiation;Radiation necrosis;Recurrence;remote monitoring;Repeat Surgery;Research Personnel;Robot;robot control;Robotics;Safety;Shapes;Site;skills;software development;Structure;System;Techniques;technology development;Temperature Sense;Tendon structure;Testing;Thermometry;Tissues;Trephine hole;tumor;tumor ablation;Tumor Tissue;United States National Institutes of Health;Work

PROJECT_TITLE: Steerable Laser Interstitial Thermotherapy (SLIT) Robot for Brain Tumor Therapy

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: NEW ORLEANS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: NARRATIVE A multi-institutional, international, and integrated endeavor, the proposed “KS in the Era of ART in Africa Program (KEAAP)” will leverage the research and training expertise of four collaborating institutions – the Louisiana State University Health Sciences Center-New Orleans, the University Teaching Hospitals and the Cancer Diseases Hospital in Lusaka, Zambia, and the Ocean Road Cancer Institute in Dar es Salaam, Tanzania – to conduct cutting edge research and capacity building activities that will lead to enhanced research infrastructure in Tanzania and Zambia and improve our understanding of one of the most prevalent HIV-associated malignancies, the Kaposi sarcoma. To promote synergy and coordination across partnering institutions, KEAAP will establish an Administrative Core that will provide day-to-day administrative support and resources, implement a consortium-wide series of operational processes, and provide communications infrastructure to engage key stakeholders and disseminate information about the consortium locally and globally. The core will focus on meeting the needs of the partnership and collaborators in the current climate of rapidly changing scientific and technological advances, which will result in a sustainable consortium with vibrant research programs that work toward the reduction of cancer in sub-Saharan Africa.

PI_NAMEs: WOOD, CHARLES  (contact)

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;African;AIDS related cancer;anti-cancer research;antiretroviral therapy;Biological Markers;Cancer Center;career development;Caring;Chronic Disease;Climate;Clinical;Collaborations;Communication;Complex;Country;data dissemination;data integration;data management;data sharing;design;Detection;Development;Diagnosis;Diagnostic;Disease;Ensure;Environment;experience;Goals;Group Meetings;Health Sciences;HIV;HIV-1;Hospitals;Human Herpesvirus 8;Immune response;Immunologics;Immunosuppression;improved;Individual;Information Dissemination;Infrastructure;Institution;International;Kaposi Sarcoma;Leadership;Location;Louisiana;Malignant Neoplasms;meetings;metabolomics;Mission;Oceans;Outcome;Outcomes Research;Pathogenesis;Persons;Pilot Projects;Policies;prevent;Prevention;Process;programs;Research;Research Activity;Research Infrastructure;Research Project Grants;Resource Sharing;Resources;Series;success;synergism;Tanzania;Teaching Hospitals;Technology;Tissues;Training;United States;United States National Institutes of Health;Universities;Viral;Viral reservoir;Virus Latency;Work;Zambia

PROJECT_TITLE: Admin Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Orphan Drug;Pain Research;Precision Medicine;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Sickle cell disease (SCD) is a disparity illness afflicting 100,000 Americans, most of whom are Black, and is more costly per-capita than any other chronic disease. The proposed work aims to improve SCD care by 1) determining which new SCD medications are most effective for which subgroups and 2) identifying genetic predictors of medication response. The proposed study will fill critical knowledge gaps and provide SCD providers with an evidence basis to choose treatments that most effectively limit organ damage and suffering.

PI_NAMEs: GLASSBERG, JEFFREY AVINS (contact);KUTLAR, ABDULLAH

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Address;Adult;African American population;African ancestry;Albumins;American;Antisickling Agents;Black American;Black race;Blood;Blood Cells;Blood Platelets;Blood Vessels;Candidate Disease Gene;Caring;Catalogs;cell type;Cells;Child;Chronic;Chronic Disease;Clinical;Clinical Data;clinical phenotype;Common Data Element;comparative;cost;Creatinine;Data;Data Analyses;Data Collection;data registry;data sharing;Development;Dictionary;Discrimination;Disease;Disease Management;disease phenotype;Disease Progression;Disparity;Early identification;Eligibility Determination;Enrollment;Epigenetic Process;Equilibrium;Erythrocytes;exome sequencing;FDA approved;Functional disorder;Funding;Future;Gene Expression Profile;gene therapy;Genetic;genetic predictors;genetic variant;genome-wide analysis;genomic predictors;Glutamine;Head;health care availability;health care service utilization;Heart;Heart Injuries;Hematological Disease;Hematopoietic;Hemoglobin;Hemolysis;Hemolytic Anemia;Hereditary Disease;high risk;hydroxyurea;Immune;Impairment;improved;Individual;individualized medicine;Inequity;Inflammatory;Infrastructure;inhibitor;Injury;Intervention;Kidney;Knowledge;Learning;Life Expectancy;Linear Regressions;Long-Term Effects;Lung;lung injury;Metadata;Misinformation;Monitor;Mononuclear;Morbidity - disease rate;mortality;mutant;National Heart, Lung, and Blood Institute;new therapeutic target;novel;novel therapeutics;Organ;organ injury;Outcome;Pain;Pain management;pain score;patient subsets;Patients;Pharmaceutical Preparations;Phase;phase III trial;Phenotype;Polymers;Population;predicting response;prevent;Prevention;pro-brain natriuretic peptide (1-76);Procedures;prospective;Prospective cohort;Protocols documentation;Provider;Randomized;randomized, clinical trials;Rare Diseases;Regimen;Registries;Renal function;Research;Research Personnel;response;Rheology;Scoring Method;Selectins;Sickle Cell Anemia;side effect;single-cell RNA sequencing;social stigma;standard of care;Stigmatization;Subgroup;Symptom Burden;Symptoms;Testing;Therapeutic;Time;transcriptome sequencing;Transfusion;treatment effect;treatment response;Uncertainty;Urine;Work

PROJECT_TITLE: "REAL Answers" (Registry Expansion Analyses to Learn)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(02)M]


NIH_SPENDING_CATS: Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention;Rare Diseases

PHR: NARRATIVE The lack of recognition of early Kaposi's sarcoma (KS) by both the health providers and PLWH, ineffective connection to diagnosis and care are some of the factors that make KS the most common malignancy in people living with HIV/AIDS (PLWH), in sub-Saharan Africa (SSA), causing significant morbidity and mortality. This study will implement an integrated KS education, diagnosis and treatment package at the Care and Treatment Clinics in order to enhance detection, and to initiate KS treatment early to improve outcomes of PLWH. This study is significant as it will lead to early KS detection, diagnosis, and linkage to care that will improve treatment outcomes and it can be readily adopted and scaled up in Tanzania and Zambia, and subsequently in other SSA countries.

PI_NAMEs: HAGENSEE, MICHAEL E (contact)

PROJECT_TERMS: Adherence;Adopted;Africa;Africa South of the Sahara;Age;AIDS with Kaposi's sarcoma;antiretroviral therapy;Awareness;Biopsy;cancer care;cancer diagnosis;care providers;care systems;Caring;Cervical Cancer Screening;Clinic;Clinical;Communities;Community Networks;Community Workers;Consent;Country;Coupling;Cutaneous;Data;Death Rate;Detection;Diagnosis;Disease;Early Diagnosis;Early treatment;Education;Effectiveness;effectiveness evaluation;empowerment;experience;Fostering;Health;Health Personnel;Healthcare;HIV;HIV/AIDS;Hospitals;implementation strategy;improved;improved outcome;Incidence;integrated care;Intervention;Kaposi Sarcoma;Knowledge;Lesion;Link;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Morbidity - disease rate;mortality;neoplastic;Network-based;Oceans;Outcome;Pathology;Persons;Physical Examination;pre-clinical;programs;Provider;Recurrence;Reporting;Respondent;Role;Sampling;scale up;screening;Services;Site;skills;Social Network;Standardization;Structure;Tanzania;Teaching Hospitals;treatment center;Treatment outcome;Universities;Zambia

PROJECT_TITLE: Project 1


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Mitigating vaccine hesitancy towards a future HIV vaccine requires strategic messaging campaigns that address public preferences, expectations, and intentions, and mitigate misinformation. This study leverages participatory research methods, health communication, and social and cognitive psychology to design and evaluate the effectiveness of crowdsourcing and deep learning computer animation interventions in optimizing HIV vaccine communication. This work will inform and support acceptance and uptake of a future, proven HIV vaccine among African Americans.

PI_NAMEs: RITCHWOOD, TIARNEY D (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: acceptability and feasibility;Address;African American population;African ancestry;animation;arm;Artificial Intelligence;Attitude;Behavior;Belief;Cognitive Science;Communication;Communities;community based participatory research;community engagement;community led intervention;community partners;Computers;Consumption;COVID-19;crowdsourcing;Data;deep learning;design;digital platform;effectiveness evaluation;expectation;experimental study;field study;Focus Groups;Future;Government Agencies;Group Processes;Guidelines;Health;health communication;Health Disparities Research;HIV;HIV vaccine;Human;Human immunodeficiency virus test;Image;Imagery;improved;Individual;Influenza vaccination;Infrastructure;innovation;insight;Institution;Intention;Intervention;literacy;Methodology;minority health;minority health disparity;Misinformation;Modeling;Morbidity - disease rate;mortality;Motivation;Movement;North Carolina;novel;novel vaccines;Outcome;pandemic disease;Patient Self-Report;Perception;Persons;Persuasive Communication;Phase;Policy Maker;Population;Populations at Risk;Predisposition;preference;Problem Solving;Public Health;racism;Randomized;Recording of previous events;Research Methodology;Research Personnel;Resources;Science;Services;social;Social Psychology;social structure;Source;Speech;tailored messaging;Techniques;Technology;Testing;therapy design;Time;Trust;United States;Universities;uptake;Vaccinated;vaccine acceptance;vaccine access;vaccine development;vaccine evaluation;vaccine hesitancy;vaccine refusal;Vaccine Research;Vaccines;Voice;willingness;Work

PROJECT_TITLE: Advancing communication strategies to support future HIV vaccine use among African Americans in the South.


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: The Rochester Toxicology Training Program provides research training and career development support for graduate students and postdoctoral fellows who are seeking careers in toxicological and environmental health sciences. This program trains future scientists to apply critical thinking, communication, and investigative skills to identify and characterize the negative impacts of chemicals and other environmental stressors on human health and resolve strategies for improving overall well-being.

PI_NAMEs: ELDER, ALISON  (contact);RAND, MATTHEW D

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: environmental toxicology;Training

PROJECT_TITLE: Training in Environmental Toxicology


NIH_SPENDING_CATS: Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases

PHR: NARRATIVE Epidemic Kaposi sarcoma (EpKS) is an HIV-associated malignancy associated with both a decline in T cell immunity and metabolic dysregulation. This inter-institutional study will investigate whether T cell immunity against the Kaposi sarcoma-associated herpes virus, as well as plasma metabolomes correlate with stage at presentation and treatment outcomes of EpKS while simultaneously integrating with other KEAPP Research Projects and providing an excellent opportunity for young investigator involvement in global oncology research with effective mentoring and career development.

PI_NAMEs: WEST, JOHN T. (contact)

PROJECT_TERMS: advanced disease;Africa;Africa South of the Sahara;AIDS clinical trial group;AIDS related cancer;AIDS therapy;AIDS with Kaposi's sarcoma;Antigens;antiretroviral therapy;Biological Markers;career development;Categories;CD4 Lymphocyte Count;Cells;chemotherapy;Clinical;co-infection;Country;Coupled;Cytolysis;Cytotoxic Chemotherapy;Data;Defect;Development;Disease;Disease Progression;Etiology;experience;Exposure to;Fatty Acids;follow-up;Glucose;glucose metabolism;Glycolysis;Growth;Herpesviridae Infections;HIV;HIV Infections;HIV therapy;Homeostasis;Human Herpesvirus 8;Iatrogenic Kaposi's Sarcoma;Immune;immune function;immune reconstitution;Immune response;Immune System Diseases;Immunity;immunological status;Immunosuppression;Immunosuppressive Agents;Immunotherapeutic agent;improved;Incidence;Individual;Infection;inter-institutional;Kaposi Sarcoma;Lesion;lipid metabolism;Lipids;Malignant Neoplasms;Mentors;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;mortality;neoplastic;neoplastic cell;neutralizing antibody;Oceans;Oncology;Opportunistic Infections;Outcome;Oxidative Phosphorylation;Participant;Pathway interactions;Patients;Persons;Plasma;Play;Prevalence;prevent;Prognostic Marker;programs;Proteins;Recurrence;Regimen;Reporting;Research;Research Personnel;Research Project Grants;responders and non-responders;response;restoration;Risk;Role;Stage Grouping;Staging;Surrogate Markers;T cell response;T-Lymphocyte;Tanzania;Teaching Hospitals;Testing;Therapeutic;Therapeutic immunosuppression;Time;transcriptomics;Treatment outcome;treatment responders;treatment response;tumor;tumor metabolism;tumorigenesis;United States National Institutes of Health;Universities;Viral;Withdrawal;Withholding Treatment;Zambia

PROJECT_TITLE: Project 2


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Lupus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE While HCQ is effective in reducing lupus disease activity and maintaining stability, over long periods, HCQ can result in ocular damage. This grant will support a phase III, randomized, double-blind, placebo-controlled, non- inferiority, multi-center clinical trial to evaluate the safety of withdrawing hydroxychloroquine (HCQ) from lupus patients 60 years and older. It is anticipated that this trial will significantly impact the care of our aging lupus population and provide a molecular landscape of autoimmune parameters which may identify patients appropriate for medication adjustments.

PI_NAMEs: BUYON, JILL P;IZMIRLY, PETER  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Address;Affect;Age;Age Years;Aging;aging population;American;arm;Asian population;Attention;Autoimmune;Award;Biological Markers;Cardiovascular system;Caring;Classification;Clinical;Clinical Trials;clinically significant;Collaborations;college;Communities;comorbidity;Congenital Heart Block;Coupled;cytokine;Data;data management;Databases;Diagnosis;Disease;disorder risk;Dose;Double-Blind Method;Elderly;electronic data capture system;Eligibility Determination;End stage renal failure;Enrollment;Equilibrium;Equipoise;Estrogens;Ethics;ethnic diversity;Evaluation;evidence base;experience;Face;Flare;follow-up;Funding;Grant;Guidelines;Hispanic Populations;Hydroxychloroquine;immunosenescence;Immunosuppressive Agents;improved;Infection;Infrastructure;insight;Institution;instrument;Intervention;Kidney Failure;life span;Long-Term Care for Elderly;Longevity;Lupus;Lupus Erythematosus;lupus registry;Maintenance;Manuals;Measurement;medical schools;medication compliance;meetings;Modeling;Molecular;Molecular Profiling;Multi-Institutional Clinical Trial;Multicenter Studies;Observational Study;older adult;older patient;Ophthalmology;Outcome;Outcomes Research;Patient Outcomes Assessments;Patient Self-Report;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Placebo Control;Placebos;Plasma;Population;pre-clinical;Pregnancy;Prevalence;Prevention;primary outcome;Procedures;Protocols documentation;Publishing;racial population;Randomized;Readiness;Recording of previous events;recruit;Regimen;retinal damage;retinal toxicity;rheumatologist;Rheumatology;Risk;Role;Safety;Salmon;Sample Size;Serology;Site;socioeconomics;Stable Disease;standard of care;Statistical Data Interpretation;Surveillance Program;Surveys;Systemic Lupus Erythematosus;Time;Toxic effect;Training Support;transcriptomic profiling;United States National Institutes of Health;Universities;Withdrawal

PROJECT_TITLE: Stopping Hydroxychloroquine In Elderly Lupus Disease (SHIELD)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Human Genome;Obesity

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE Trim28 is a master regulator of phenotypic and metabolic disease variation that normally works with KRAB zinc-finger proteins to keep endogenous retroviruses (ERVs) in an inactive, silenced state within the cell. We now have evidence that some ERVs can be activated by ZF-CxxC proteins, and that distinct subsets of ERV activation correlate with distinct classes of human phenotypic variation. In this project, we will show that Trim28/ZF-CxxC competition is a novel mechanism governing the variable silencing at ERVs, and that ERV activation is coupled to unexplained metabolic disease heterogeneity.

PI_NAMEs: POSPISILIK, JOHN ANDREW (contact);SCHONES, DUSTIN EDWARD

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Adipocytes;Animal Model;Animals;Binding;Buffers;Cells;Characteristics;Chromatin;Communities;Competitive Binding;Complex;Coupled;Data;Development;Disease;disease heterogeneity;Disease Outcome;DNA Methylation;Endogenous Retroviruses;Enhancers;Environment;Epigenetic Process;epigenetic silencing;epigenomics;Equilibrium;Etiology;Exhibits;experimental study;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Epistasis;Genome;Genomics;Hepatocyte;Heterogeneity;Heterozygote;Human;in vivo;Inbreeding;Incidence;Individual;Lead;male;Measures;Mediating;Metabolic Diseases;Methylation;methylation pattern;mRNA Expression;Mus;non-genetic;novel;Obesity;Other Genetics;Pathway interactions;Phenotype;promoter;Protein Binding Domain;Proteins;recruit;Repression;Research;Severities;Testing;Tissues;transcriptome sequencing;Translating;Twin Multiple Birth;Variant;Work;Zinc Fingers

PROJECT_TITLE: A Trim28-ERV axis drives phenotypic variation in obesity

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Emergency Care;Health Services;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: We propose state-of-the-art natural language processing (NLP) and deep learning technologies to automatically assess the contextual diagnostic certainty of the computed tomographic pulmonary angiography (CTPA) reports, holds great potential of bridging the communication gaps between radiologists and ordering physicians. We will conduct user centric evaluation to assess if the system can help improve the agreement between the radiologists and ordering physicians in their perceived diagnostic certainty level. This study will build the foundation for future implementation and integration of DeepCertainty into clinical workflows to prompt real-time low-certainty alerts for improving PE diagnostic reporting quality and clarity, which will inform better treatment decisions for ED patients with suspected PE.

PI_NAMEs: LIU, FEIFAN  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Accident and Emergency department;accurate diagnosis;accurate diagnostics;Address;Adopted;Adoption;adverse outcome;Agreement;American College of Radiology;Angiography;Awareness;Calibration;Cardiovascular system;Caring;Categories;Cessation of life;Clinical;clinical decision-making;Communication;Complex;computerized;Computing Methodologies;cost outcomes;Data;Data Set;Decentralization;deep learning;design;Diagnosis;Diagnostic;Diagnostic Errors;Diagnostic Imaging;Diagnostic tests;Disease;Effectiveness;Emergency Department patient;Emergency Department Physician;Emergency department visit;Emergency Situation;Ensure;Evaluation;Exclusion;Feedback;Foundations;Funding;future implementation;Grain;Guidelines;Healthcare;Hospitalization;Image;Image Analysis;imaging modality;impression;improved;Individual;innovation;Inpatients;Institution;Intensive Care Units;Knowledge;Language;Learning;lexical;Lung;Magnetic Resonance Imaging;Manuals;Measurement;Measures;Medical;Modeling;Morbidity - disease rate;mortality;Natural Language Processing;neural;Outpatients;Patient Care;Patients;Perception;Persons;Physicians;prevent;Process;Pulmonary Embolism;Quality of Care;radiologist;Radiology Specialty;rapid diagnosis;Reporting;Sampling;Semantics;Signs and Symptoms;Specific qualifier value;Standardization;statistics;Stress;Structure;System;Technology;Testing;Time;Uncertainty;United States;unnecessary treatment;user-friendly;Variant;Workplace;X-Ray Computed Tomography

PROJECT_TITLE: DeepCertainty: Deep Learning for Contextual Diagnostic Uncertainty Measurement in Radiology Reports

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: AUSTIN

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative The goal of this proposal is to train pre- and post-doctoral scholars in vision, visual neuroscience and visually guided behavior. The program emphasizes the study of natural environments, natural tasks, and neural computation, because the study of vision in its natural generalizes more readily to clinical issues than restricted laboratory experiments, and provides a body of comparable data in normal populations. Students training in our program will have a suitable background for future work in clinical populations as they will learn a variety of relevant techniques such as eye tracking in unrestricted behavior and use of virtual environments, as well as developing a sound in background computational methods and in the neural basis of visually guided behavior.

PI_NAMEs: HAYHOE, MARY M (contact);HUK, ALEXANDER C

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Grant;Training

PROJECT_TITLE: CPS Training Grant


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases

PHR: PROJECT NARRATIVE Kaposi sarcoma (KS), a common cancer in sub-Saharan Africa and in people living with HIV-1, is often aggressive with a high rate of recurrence despite antiretroviral therapy and chemo/radiotherapy. Kaposi sarcoma-associated herpesvirus (KSHV), the causative agent of KS, can remain latent in an infected individual for life and can periodically re-emerge from infected cells, but where the KSHV persistently infected cells or KS tumor cells are located in the human body (reservoirs) is not known. Hence, we propose to identify the KSHV reservoirs in humans by examining tissues collected from KSHV infected postmortem donors.

PI_NAMEs: TSO, FOR YUE  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adult;Affect;Africa;Africa South of the Sahara;Aftercare;AIDS related cancer;Animal Model;antiretroviral therapy;Autopsy;brain tissue;cell transformation;cell type;Cells;co-infection;Cohort Studies;Collaborations;Country;Coupled;Development;Disease;Drug resistance;emerging virus;Etiology;Future;Herpesviridae;Herpesviridae Infections;High Prevalence;Histologic;HIV;HIV Infections;HIV-1;Hospitals;Human;Human body;Human Herpesvirus 8;Immune system;Incidence;Individual;Infection;Kaposi Sarcoma;Lesion;Life;Location;Lytic;lytic gene expression;Malignant Neoplasms;Morbidity - disease rate;mortality;neoplastic cell;novel;Oceans;Pathology;Patients;peripheral blood;Persons;Plasma;programs;Radiation therapy;reconstitution;Recurrence;Research;Research Institute;Research Personnel;Risk;Sampling;seropositive;Seroprevalences;Site;social;Tanzania;Teaching Hospitals;therapy design;Tissues;transforming virus;Treatment Failure;Uganda;Universities;viral DNA;Viral Load result;viral RNA;Zambia

PROJECT_TITLE: Project 3


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Wound Healing and Care

ORG_CITY: LA JOLLA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Narrative The proposed studies focus on small extracellular vesicles secreted by wound macrophages in sites of injury that regulate stromal cells by suppressing the inflammation phase to promote re- epithelialization. We hypothesize that a mechanistic understanding of how small extracellular vesicles are formed, what contents are biologically active, and which cells uptake these vesicles is critical for the over-arching goal of developing extracellular vesicles that have therapeutic potential by promoting the resolution of inflammation and wound closure.

PI_NAMEs: ELICEIRI, BRIAN P (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Biogenesis;Biological;Biology;Biomedical Engineering;cell type;Cells;Engineering;Epithelial Cells;extracellular vesicles;Genetic;genetic approach;Goals;Immune;Impaired wound healing;Inflammation;Injury;Intercellular Communication Process;Knowledge;Macrophage;Mass Spectrum Analysis;Mediating;Mediator;Modeling;novel;Nucleic Acids;overexpression;Phase;programs;Proteins;re-epithelialization;Regulation;Resolution;Signal Transduction;Site;skin wound;Skin wound healing;Stromal Cells;Therapeutic;tissue repair;tool;uptake;Vesicle;wound;wound bed;wound closure;wound healing;Wound models

PROJECT_TITLE: Mechanisms of extracellular vesicle biogenesis that regulate wound healing


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Lung;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Patients with chronic illness who develop acute respiratory failure have a high risk of death or disability; as such, clinicians who treat these patients should always engage patients and families to ascertain their goals of care. However, prior studies and my preliminary data suggest that this important conversation often does not take place—and, when it does take place, the quality of the discussion is often poor. In this K23, I will examine existing deficiencies in clinicians’ communication practices, and design and evaluate novel strategies to improve communication for patients with chronic illness and acute respiratory failure; these activities will train me to become an independent physician-scientist conducting patient-oriented research to improve patient outcomes.

PI_NAMEs: LEE, ROBERT YING-FU (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute respiratory failure;Admission activity;Adopted;Adoption;analytical method;Area;behavior change;Behavioral;career;Caring;Chronic;Chronic Disease;Clinical Investigator;Clinical Trials;cohort;Communication;cost;Data;Decision Making;design;disability;Discipline of Nursing;Documentation;effectiveness/implementation trial;Electronic Health Record;Environment;Environmental Risk Factor;Ethnic Origin;Etiology;Exclusion;Expectancy;experience;Family;Foundations;Future;Goals;Guidelines;Health;Health system;high risk;Hospitalization;improved;improved outcome;Incidence;Intensive Care;Intervention;Interview;Life;Logistic Regressions;Measurement;Measures;Mechanical ventilation;medical schools;Medicine;Mentors;Methods;mortality risk;Natural Language Processing;novel strategies;Observational Study;Outcome;Outpatients;Palliative Care;patient engagement;patient oriented research;Patient-Focused Outcomes;Patients;Physicians;Population;preference;primary outcome;Process;Prognosis;prognostic;provider communication;Public Health;Publishing;racial minority;randomized trial;Recommendation;Reporting;Research;Research Activity;Research Design;Research Methodology;Research Training;Scientist;secondary outcome;Severity of illness;shared decision making;Structure;Surveys;Testing;Theoretical Domains framework;therapy design;Time Factors;Training;Training Activity;Universities;usability;Washington;Work

PROJECT_TITLE: Improving goals-of-care discussions for patients with chronic life-limiting illness and acute respiratory failure

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases

PHR: NARRATIVE The KEAAP Data Management and Integration Core (DMIC) will establish an inter-institutional network providing study databases, biostatistics and epidemiology expertise, training, and technology support. The DMIC will work across the scientific spectrum from biology, biochemistry, and immunology to implementation science and clinical connection to support and accelerate translational research by KEAAP investigators. The DMIC is responsible for streamlining and coordinating data management, analytical procedures, statistical analysis, and biospecimen storage in support of clinical research proposed by the KEAAP research projects and pilot projects.

PI_NAMEs: FERGUSON, TEKEDA F. (contact)

PROJECT_TERMS: Acceleration;Address;Adherence;Africa;AIDS related cancer;analytical tool;antiretroviral therapy;Area;arm;Biochemistry;Bioinformatics;Biology;Biometry;career;Caring;Clinical;Clinical Informatics;Clinical Research;cloud based;Collaborations;Communication;Communities;Computer software;Country;Data;Data Analyses;Data Collection;data integration;data integrity;data management;Data Management Resources;Data Security;data sharing;Database Management Systems;Databases;design;Development;Disease;Educational workshop;electronic data;empowerment;Ensure;Epidemiologic Methods;Epidemiologist;Epidemiology;Equipment and supply inventories;Evaluation;Experimental Designs;experimental study;Fostering;Funding;Geographic Distribution;Goals;Health Sciences;HIV;Hospitals;Human Resources;Immunology;implementation science;Individual;Institution;inter-institutional;Kaposi Sarcoma;Knowledge;Knowledge acquisition;knowledge integration;Laboratory Study;Louisiana;Malignant Neoplasms;Manuscripts;member;Mentors;Modeling;novel;Oceans;Persons;Pilot Projects;Play;prevent;Procedures;Productivity;Program Research Project Grants;programs;Progress Reports;Protocols documentation;Public Health Schools;Publications;Quality Control;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Research Proposals;Research Support;Resource Informatics;Resources;Role;sample collection;Science;Scientist;Security;Services;Site;Standardization;Statistical Data Interpretation;Statistical Methods;student training;System;Tanzania;Teaching Hospitals;Technology;Testing;Time;tool;Training;Translational Research;Universities;Work;Zambia

PROJECT_TITLE: Data Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Regenerative Medicine;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: BIOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE /RELEVANCE Bone is a preferred organ for cancer dissemination (metastasis) which most of the times is a terminal condition. We propose to understand the mechanism(s) behind the establishment of bone metastasis based on a novel hypothesis suggesting that perivascular cells in the bone marrow control cancer cell invasion to the bone. This new hypothesis provides clinically relevant information for therapeutic strategies that innovately aim at reducing bone metastasis by closing the gate through which the metastatic cancer cell transit into the bone, thus, providing a paradigm for improving the devastating outcomes of bone metastasis.

PI_NAMEs: SOMOZA, RODRIGO ALFONSO (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Address;anti-tumor immune response;Attenuated;Automobile Driving;Back;Basement membrane;Binding;Blood;Blood Vessels;bone;bone invasion;Bone Marrow;bone marrow mesenchymal stem cell;Breast Cancer Cell;Breast Cancer cell line;calcium phosphate;cancer cell;Cancer Control;Cell Line;Cell secretion;Cell Surface Receptors;cell type;Cells;Ceramics;circulating cancer cell;Clinical;clinically relevant;Communication;CXCR4 gene;CXCR4 Receptors;Data;Databases;design;Diagnostic;Discontinuous Capillary;Disseminated Malignant Neoplasm;Engraftment;Extracellular Matrix;Extravasation;Future;Gatekeeping;Genes;Genetic;Genetic Models;genetic variant;Genetic Variation;Habitats;Hematopoietic;hematopoietic stem cell niche;Hematopoietic stem cells;Homing;Human;immunodeficiency;Implant;improved;in vitro Assay;in vivo;Infiltration;innovation;Integrin alpha6beta1;Invaded;Laminin;Leukocytes;Ligands;Location;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Marrow;MCAM gene;Melanins;Melanoma;Mesenchymal Stem Cells;Metastatic Neoplasm to the Bone;metastatic process;Modeling;Modification;Molecular;Molecular Target;mouse model;Mus;Nature;Neoplasm Metastasis;neoplastic cell;novel;Organ;Outcome;patient response;Patients;Pericytes;Platelet-Derived Growth Factor;Play;Population;Porosity;prevent;Process;Production;Protein Isoforms;Proto-Oncogene Protein c-kit;Regulation;Research Proposals;Role;Side;Site;Skeleton;Sorting;Stem Cell Factor;Stream;Stromal Cell-Derived Factor 1;substantia spongiosa;Supporting Cell;Survival Rate;System;targeted treatment;Testing;Therapeutic;Time;trafficking;tumor;Tumor Angiogenesis;Tumor Cell Invasion;vascular factor;Work

PROJECT_TITLE: Role of Perivascular Mesenchymal Stem Cells (pMSCs) in the Bone Marrow Niche and the Extracellular Matrix in the Control of Skeletal Metastasis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE This study will build the evidence base for infection prevention practices to prevent the transmission of respiratory viruses in healthcare. This study will develop size-selective inlets for an innovative sampling instrument designed to measure airborne viable virus, and use this instrument in conjunction with conventional aerosol sampling equipment to comprehensively characterize respiratory aerosols generated by and from patients with COVID-19 or influenza. The concentration and size distribution of infectious aerosols is poorly understood but critical for the assessment of infection risk and control strategies.

PI_NAMEs: JONES, RACHAEL MARY;KELLY, KERRY  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Achievement;acute care;aerosolized;Aerosols;Characteristics;coarse particles;Collection;Consensus;COVID-19;COVID-19 patient;Deposition;design;Detection;detection limit;Development;Devices;disease transmission;Enterobacteria phage MS2;Environmental Risk Factor;Environmental Wind;epidemiology study;Equipment;Evaluation;evidence base;experience;fine particles;Genes;Genetic Materials;Goals;Growth;Health;Health care facility;health care settings;Health Personnel;Healthcare;Healthcare Activity;high risk;hospital analysis;Hospitalization;improved;Infection;Infection Control;Infection prevention;infection risk;Influenza;Influenza A virus;Influenza B Virus;Inhalation;innovation;instrument;Knowledge;Link;Liquid substance;Measurement;Measures;meetings;Methods;microbial;Microbiology;Occupational Health;Occupations;Outcomes Research;Patient Care;Patients;Pattern;Performance;Physical condensation;prevent;Prevent viral transmission;prevention practice;Procedures;Process;Property;Research;Research Personnel;respiratory aerosol;Respiratory Disease;Respiratory System;Respiratory Tract Infections;respiratory virus;Risk;Risk Assessment;Route;Sampling;Science;seasonal influenza;Speed;Standardization;symposium;transmission process;Tube;Variant;virology;Virus;Virus Diseases;virus genetics;Work

PROJECT_TITLE: Linking SARS-CoV-2 Aerosol Viability and Environmental Factors in Healthcare Settings

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


PHR: NARRATIVE The overall goal of the KS in the Era of ART in Africa Program Career Developmental Core is to provide targeted mentoring and research training activities to support the research, career, and leadership development of promising young investigators at the University Teaching Hospital and Cancer Diseases Hospital in Zambia, the Ocean Road Cancer Institute in Tanzania, and Louisiana State University Health Sciences Center–New Orleans, and to incentivize collaborative and tri- directional HIV associated malignancies research that is relevant both in the US and abroad. To achieve this goal, the Core will implement an integrated and interinstitutional pilot project program, short-term training exchanges between institutions, workshops and skills development activities and a careful career and leadership development program. They are designed to help new investigators from the US, Tanzania, and Zambia, to effectively tackle research, compliance, grantsmanship/authorship and logistical challenges to become increasingly competitive in global oncology activities.

PROJECT_TERMS: Academic Training;Address;Affect;Africa;Africa South of the Sahara;African;AIDS related cancer;anti-cancer research;antiretroviral therapy;Area;Authorship;Autopsy;Basic Science;Bioinformatics;Biological Markers;Biomedical Research;Biometry;Cancer Center;Cancer Research Infrastructure;career;career development;Caring;Clinical;Clinical Medicine;Clinical Sciences;Collaborations;Communicable Diseases;comparative;Country;Coupled;Database Management Systems;Databases;design;Development;Diagnosis;Diagnostic;Disease;Educational workshop;Etiology;experience;Faculty;Fostering;Funding;Genetic;global health;Goals;Health;Health Sciences;Histopathology;HIV;HIV-1;HIV/AIDS;Hospitals;Human Herpesvirus 8;Human Resources;Immunologics;Immunology;implementation science;improved;Incentives;Incidence;Institution;inter-institutional;interest;Internet;Kaposi Sarcoma;leadership development;Louisiana;low and middle-income countries;Malignant Neoplasms;Medical;Mentors;metabolomics;National Institute of General Medical Sciences;neoplastic;next generation;Oceans;Oncology;Outcome;peer;peer coaching;peer networks;Persons;Pilot Projects;Prevention;Productivity;Program Development;Program Research Project Grants;programs;Public Health;Public Health Schools;radiological imaging;Research;Research Activity;research and development;Research Institute;Research Personnel;Research Support;Research Training;Resources;skill acquisition;skills;success;Tanzania;Targeted Research;Teaching Hospitals;Tissues;Training;Training Activity;training opportunity;Training Programs;United States;Universities;Viral;Viral reservoir;Virus Latency;virus related cancer;Zambia

PROJECT_TITLE: Developmental Core


ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Through this T32 postdoctoral Translational Vision Research Training program at UCSD, we will combine excellence in research mentoring, didactic education, and career development to bring new scientists to careers in vision research.

PI_NAMEs: ZANGWILL, LINDA M (contact)

PROJECT_TERMS: Research Training;Vision research

PROJECT_TITLE: Translational Vision Research Training at UCSD


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This computational psychiatry proposal aims to address significant gaps in our understanding of how prefrontal cortical N-methyl-D-aspartate (NMDA) receptor loss contributes to functional and structural synaptic changes in schizophrenia. Integrating electrophysiological and morphological analysis of pyramidal neurons will provide valuable insights for understanding how excitatory synaptic abnormalities lead to network-level pathophysiology, with implications for loss of cognitive function. The long-term goal of this proposal is to improve our understanding of brain circuit disruption in schizophrenia, and eventually guide the development of targeted neuromodulation- based therapies to repair neural circuits and restore working memory in patients.

PI_NAMEs: DICK, RACHEL  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Ablation;Acids;Acute;Address;Affect;AMPA Receptors;Apical;Architecture;Autopsy;Behavioral;Biological;Brain;brain abnormalities;Brain region;career;Cells;Chronic;cognitive function;Complex;computational neuroscience;confocal imaging;Confocal Microscopy;Data;Dendritic Spines;density;Development;Diameter;disability;Dyes;Electrophysiology (science);emotional distress;excitatory neuron;Excitatory Synapse;experimental study;Foundations;Frequencies;Functional disorder;Future;genome editing;Goals;hippocampal pyramidal neuron;Image;Impaired cognition;improved;in vivo;insight;Lead;Length;life span;mathematical model;Mathematics;Measures;Medial;Memory impairment;Memory Loss;Mental disorders;Mentorship;Minnesota;Modeling;Morphology;Mus;N-Methyl-D-Aspartate Receptors;network models;neural;neural circuit;neural network;neural repair;Neurobehavioral Manifestations;neurobiotin;Neurons;neuroregulation;neurotransmission;neurotransmitter release;nonhuman primate;patch clamp;Patient-Focused Outcomes;Patients;Pattern;Persons;pharmacologic;Pharmacological Treatment;Pharmacology Study;Population;postsynaptic;Prefrontal Cortex;presynaptic;Primates;Probability;Process;Psychiatry;Pyramidal Cells;Receptor Down-Regulation;receptor downregulation;receptor expression;Research;Role;Schizophrenia;Short-Term Memory;Site;Slice;Structural defect;Synapses;synaptic function;Testing;Tissues;Training;transmission process;United States National Institutes of Health;Universities;Vertebral column;Visualization

PROJECT_TITLE: Functional, structural, and computational consequences of NMDA receptor ablation at medial prefrontal cortex synapses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F01A-V(20)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder affecting 1 in 53 children in the US, and at least 15% of male patient with ASD, who suffer from severe symptoms, show macrocephaly (large brain), especially in the prefrontal cortex that mediates social cognition and language. Our central hypothesis is that excessive embryonic neurogenesis, which results in macrocephaly, is sufficient to elicit some ASD-like symptoms by disturbing cell signaling and composition in the postnatal brain. We will test the hypothesis by investigating a novel mouse model of ASD with a gain-of-function mutation in the neurodevelopmental gene ASPM (abnormal spindle-like microcephaly-associated), a major determinant of brain size that controls cortical progenitor proliferation.

PI_NAMEs: BAE, BYOUNG-IL  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Address;Adult;Affect;ARHGEF5 gene;ASD patient;autism spectrum disorder;autism symptoms;Behavior;Behavioral Assay;beta catenin;boys;Brain;brain size;Cell Aging;Cell Cycle;Cell Death;Cell Proliferation;cell type;Cells;Centrosome;Cerebral cortex;Child;Cognitive;CTNNB1 gene;Cultured Cells;Data;de novo mutation;Development;DLG4 gene;early childhood;Embryo;FOS gene;Functional disorder;gain of function;gain of function mutation;Gene Abnormality;gene product;Genes;Genetic;Goals;Heritability;Human;Immediate-Early Genes;In Situ Hybridization;innovation;Knock-in;Knock-in Mouse;Language;loss of function mutation;Macrocephaly;male;Mammals;Medial;Mediating;Microcephaly;Missense Mutation;model of autism spectrum disorder;mouse model;Mus;Mutation;Neurodevelopmental Disorder;Neuroepithelial Cells;neurogenesis;Neuroglia;Neuronal Differentiation;Neurons;novel;novel therapeutic intervention;Patients;Perinatal;postnatal;Prefrontal Cortex;progenitor;Proliferating;Proteins;PTEN gene;PTPNS1 gene;Radial;Research;risk variant;Role;Signal Pathway;Signal Transduction;Signaling Molecule;single nucleus RNA-sequencing;social;Social Behavior;social cognition;Social Controls;stem cell proliferation;Symptoms;Synapses;Techniques;Testing;Undifferentiated;Variant;Weight

PROJECT_TITLE: Mechanisms by Which Macrocephaly Underlies Autism Spectrum Disorder

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: TALLAHASSEE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE  Monoclonal antibodies (mAbs) provide a promising platform for treatment of cancer and major infectious diseases, including COVID-19. However, their processing and administration are challenging due to presence of hydrophobic interfaces, which may in turn adversely affect their native higher order structures (HOS). The proposed research seeks to understand the nature of interactions between mAbs and hydrophobic interfaces and the effects of stabilizers (i.e., surfactants) on mAb native HOS, which will advance our fundamental knowledge of mAb interactions with hydrophobic interfaces and help mitigate risks in developing these therapeutics for various applications. 1

PI_NAMEs: MOHAMMADIGOUSHKI, HADI  (contact)

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: Adsorption;Affect;Air;Autoimmune Diseases;Binding;Biological Response Modifier Therapy;bioprocess;cancer therapy;Cardiovascular Diseases;Chemicals;Communicable Diseases;COVID-19;COVID-19 treatment;Development;Diffusion;experience;Formulation;Foundations;Frequencies;Future;Grant;Higher Order Chromatin Structure;Hydrophobicity;immunogenicity;improved;In Situ;indexing;interfacial;Ionic Strengths;Isotope Labeling;Kinetics;Knowledge;Laboratories;Life;Location;macromolecule;magnetic field;Magnetic Resonance Imaging;Malignant Neoplasms;Maltose;Measurement;Measures;Middle East Respiratory Syndrome Coronavirus;Modeling;Molecular;Molecular Probe Techniques;Monoclonal Antibodies;Nature;Neutrons;NMR Spectroscopy;novel;Nuclear Magnetic Resonance;Oils;Outcome Study;Patients;Pharmaceutical Preparations;Polysorbates;Predisposition;programs;Proteins;quantum;Relaxation;Research;Resolution;Risk;risk mitigation;Roentgen Rays;Safety;SARS coronavirus;Spectrum Analysis;Structure;Surface;Surface Tension;surfactant;Syringes;System;Techniques;Temperature;Testing;Therapeutic;therapeutic protein;Time;Transportation;Viral;Virus Diseases;Water

PROJECT_TITLE: Probing in situ higher order structures of monoclonal antibodies at water-air and water-oil interfaces via high-field nuclear magnetic resonance spectroscopy for viral infections

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Nutrition

PHR: PROJECT NARRATIVE Cells allocate substantial resources towards monitoring their energy level, and appropriately adjust energy generation rates based on the metabolic demand and nutrients status to maintain homeostasis. This proposal aims to understand how cellular metabolic state regulates mitochondrial function and dynamics, and how it contributes to bioenergetics in the cells. These studies will produce important insights into the biochemical pathways that underlie neuronal functions, cell migration in cancer and wound healing, nervous system development, nutritional and mitochondrial disorders, and obesity.

PI_NAMEs: PEKKURNAZ, GULCIN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Architecture;Biochemical Pathway;Biochemistry;Bioenergetics;cell motility;Cells;Chemicals;Communication;detection of nutrient;Dimensions;Disease;Energy Supply;Enzymes;Eukaryotic Cell;experimental study;Generations;Goals;Heterogeneity;Homeostasis;Immunity;Impairment;insight;Interdisciplinary Study;Intracellular Space;Intracellular Transport;Kinetics;Malignant Neoplasms;Mammalian Cell;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Mitochondrial Diseases;Mitochondrial Proteins;Molecular;Monitor;nervous system development;Neurons;Nutrient;Nutrient availability;Nutrition Disorders;Obesity;Organelles;Pathway interactions;Positioning Attribute;Post-Translational Protein Processing;programs;Proteins;Regulation;Research;Resources;Shapes;Signal Pathway;spatiotemporal;Tumor Cell Invasion;wound healing

PROJECT_TITLE: Metabolic Regulation of Mitochondrial Function


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE People with autoimmune rheumatic diseases (AIRDs) such as rheumatoid arthritis or systemic lupus erythematosus, especially those on immunosuppressive treatment, often experience poorer outcomes following COVID-19 infection. Individuals with AIRDs, including Black and Latinx persons, are concerned about side effects, may have limited awareness about the complexity of COVID-19 vaccination and timing of subsequent vaccine doses in the context of AIRD and/or immunosuppressive treatment, or may have barriers to obtaining a COVID-19 vaccine dose. This study aims to test whether a novel intervention using first-person narratives (i.e., “storytelling”) recounting personal experiences with the COVID-19 vaccination as well as patient navigation to provide logistics support for and reinforce safety and effectiveness of COVID-19 vaccination will result in an increase in vaccination uptake among Black and Latinx adults with AIRDs.

PI_NAMEs: DANILA, MARIA IOANA (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Address;Adult;Advisory Committees;Alabama;American;Area;attentional control;autoimmune rheumatologic disease;Awareness;Behavior;behavior change;Black Populations;Black race;booster vaccine;Caring;Cessation of life;Clinic;Clinic Visits;college;Communication;Communities;community engagement;Complex;Confusion;COVID-19;COVID-19 booster;COVID-19 vaccination;COVID-19 vaccine;diet and exercise;Disparity;Dose;Education;Effectiveness;effectiveness testing;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;experience;Exposure to;flexibility;Fostering;Fright;Funding;Future;General Population;Geographic Locations;Geography;good diet;group intervention;Health;health equity;health inequalities;Health Status;high risk;Hospitalization;Immunosuppressive Agents;improved;Individual;Inequity;influenza virus vaccine;innovation;Insurance Coverage;Intervention;intervention effect;Interview;Latinx;Latinx population;Logistics;marginalized population;Massachusetts;Measures;Medicaid;member;Methods;Mind;Minority Groups;minority patient;Misinformation;Modeling;multi-component intervention;multidisciplinary;Narration;National Center for Advancing Translational Sciences;novel;Outcome;Participant;patient navigation;patient navigator;Patient Self-Report;Patients;people of color;Persons;Pharmaceutical Preparations;Population;Population Heterogeneity;post SARS-CoV-2 infection;primary endpoint;Privatization;Proxy;racial diversity;racial minority;racial population;Randomized;Recommendation;Records;recruit;Research;Resources;Rheumatism;Rheumatoid Arthritis;Rheumatology;Risk;Safety;scale up;Self Efficacy;Series;severe COVID-19;side effect;simulation;social;Structure;Surveys;Systemic Lupus Erythematosus;Tablet Computer;Telephone;Testing;Training;treatment as usual;Uninsured;United States National Institutes of Health;uptake;Vaccinated;Vaccination;vaccine acceptance;vaccine efficacy;Vaccinee;Vaccines;video chat;virtual;Work

PROJECT_TITLE: Improving COVID-19 Vaccine Uptake Among Racial and Ethnic Minority Groupswith Rheumatic Diseases

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Bioengineering;Hematology

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE: Disruption of the ankyrin-1 complex by inherited mutations is a feature of several hereditary anemias, including hereditary spherocytosis (HS). In HS mutant red blood cells, the curvature of the membrane is disrupted, and cells become much more fragile, but the architecture of the ankyrin-1 complex and the mechanism by which it controls membrane curvature is poorly understood. We seek to address this by characterizing the structure and function of the ankyrin-1 complex, both purified and in the context of the human red blood cell membrane.

PI_NAMEs: CLARKE, OLIVER BIGGS (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Actins;Address;Ammonia;Anemia;Anions;ANK1 gene;Ankyrins;AQP1 gene;Architecture;Bicarbonates;Binding;Binding Sites;Biological Assay;CD47 gene;Cell membrane;Cells;Complex;conformational conversion;crosslink;Cryo-electron tomography;Cryoelectron Microscopy;Cytoskeleton;Data;Detergents;Diffusion;Digitonin;dimer;Erythrocyte Membrane;Erythrocytes;Event;experimental study;Gases;Glycophorin B;Goals;GYPA gene;Hereditary Spherocytosis;Heterogeneity;Human;In Situ;Inherited;insight;Lipid Bilayers;Lipids;Liposomes;Literature;mechanical properties;Mediating;Membrane;Membrane Proteins;Methods;Micelles;Molecular Conformation;molecular dynamics;molecular scale;Morphologic artifacts;mutant;Mutation;nanodisk;novel;particle;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phospholipase C;Physiological;Play;polypeptide;Population;Preparation;Process;Property;protein complex;protein purification;Proteins;Recombinants;reconstruction;Regulation;Reporting;Research;Resolution;Rhesus;Sampling;Scaffolding Protein;Shapes;Site;Skeleton;Sodium Channel;Spectrin;Structure;Tissues;Transmembrane Domain;uptake;Vesicle;Voltage-Gated Potassium Channel;Western Blotting;Work

PROJECT_TITLE: Architecture, dynamics and regulation of erythrocyte ankyrin-1 complexes

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: PROJECT NARRATIVE Parkinson's disease (PD) is a life-destructive neurodegenerative disease that affects over 1 million Americans with no available treatment to slow disease progression. Although researchers have learned a great deal about PD pathophysiology through cellular and animal models, the findings have had limited translational impact due to challenges in recapitulating the most disease-relevant attributes of human brain structure and function. The field is in need of a high-throughput PD testbed that features a three-dimensional structure mimicking key features of PD vulnerability and pathology, including human neural cell populations organized based on systems-level architecture that are – most importantly – spanned by bundled long-projecting axon tracts. As such, this project will validate the first PD model featuring anatomically inspired microtissue, and then apply this novel platform for the mechanistic study of PD axonopathy, pathophysiology, and pharmacological interventions to block axon-mediated spread of pathological alpha-synuclein across discrete brain structures. !

PI_NAMEs: DUDA, JOHN ERIC (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Address;Affect;alpha synuclein;American;Anatomy;Animal Model;Architecture;Axon;axonal degeneration;axonopathy;Beds;Brain;brain pathway;Cell model;Cell Proliferation;Cell Survival;cell type;Cells;Clinical;Complex;Corpus striatum structure;density;Diagnosis;disability;Disease;disease model;Disease Progression;Dopamine;dopaminergic neuron;Elements;Endowment;Ensure;Feedback;foot;FRAP1 gene;Functional disorder;Genetic;Growth;Human;human disease;human induced pluripotent stem cells;human stem cell-derived;immunocytochemistry;In Vitro;in vitro testing;in vivo Model;Induced pluripotent stem cell derived human neuron;Intervention;Label;Learning;Length;Life;Mediating;Metabolic;Microscopy;Modeling;Motor;motor control;motor symptom;mTOR inhibition;multidisciplinary;Nerve Degeneration;Nervous System;neural circuit;Neurodegenerative Disorders;Neuroglia;neuroimaging;Neurons;neuroprotection;nigrostriatal pathway;novel;Output;overexpression;Parkinson Disease;Parkinsonian Disorders;pars compacta;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Periodicity;pharmacologic;Phenotype;Play;Population;postsynaptic;Pre-Clinical Model;pre-formed fibril;Predisposition;presynaptic;Presynaptic Terminals;prevent;Prevention;Process;Proteins;Research;Research Personnel;Resolution;response;Rodent;Rodent Model;Role;Scanning;Signal Transduction;Sirolimus;Source;Specialist;stem cells;Structure;Substantia nigra structure;Symptoms;Synapses;synaptogenesis;synuclein;synucleinopathy;System;targeted treatment;Testing;Therapeutic;therapeutic development;three dimensional structure;Time;Tissue constructs;Tissue Engineering;Tissues;translational approach;translational impact;Translations;transmission process;Tyrosine 3-Monooxygenase;uptake;Validation;Work

PROJECT_TITLE: Tissue engineered Nigrostriatal Pathway as a testbed for evaluating axonal pathophysiology in Parkinson's disease.


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative MERS-CoV (MERS) and SARS-CoV-2 (SARS-2) are highly pathogenic coronaviruses that have recently emerged into human populations and caused devastating public health crises. Though the respiratory epithelium in the nose is the primary site encountered by all respiratory viruses, the role of various aspects of antiviral innate immunity in the nose has not been investigated in the context of infection by these viruses. This project aims to determine the role of these host responses in limiting MERS and SARS-2 replication in the upper airway, which will increase our understanding of virus-host interactions in the nasal mucosa and inform potential therapeutic strategies.

PI_NAMEs: OTTER, CLAYTON  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 2019-nCoV;A549;Agonist;Air;airway epithelium;Alveolar;antagonist;anti-microbial peptide;Anti-viral Agents;Apical;Attenuated;Basal Cell;betacoronavirus;Cell Death;Cell Line;Cell Physiology;cell type;Cells;Cellular Tropism;Cilia;Coronavirus;Coronavirus Infections;coronavirus therapeutics;cytokine;Data;Disease;Disease Outbreaks;Double-Stranded RNA;Epithelium;experimental study;Frequencies;Future;Goblet Cells;Host Defense;Human;Immune;Immune response;Immunity;Immunocompetent;in vivo;Infection;Influenza A virus;innate immune pathways;Innate Immune Response;Innate Immune System;insight;Interferons;Interleukin-13;Ligase;Liquid substance;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Mucous body substance;Mucous Membrane;mutant;Nasal Epithelium;Natural Immunity;Nitric Oxide;Nose;novel;novel coronavirus;oligoadenylate;pathogen;Pathogenicity;Pathway interactions;Patients;pharmacologic;Play;Population;prevent;Process;Production;protein kinase R;Proteins;Public Health;public health emergency;recombinant virus;Recombinants;Reporting;respiratory;respiratory infection virus;Respiratory System;respiratory virus;response;Ribonucleases;RNA Viruses;Role;Sampling;SARS-CoV-2 infection;Signal Transduction;Site;Structure of mucous membrane of nose;System;Testing;Therapeutic;tool;Tropism;Viral;Virus;Virus Diseases;virus host interaction;Virus Replication;Work;zoonotic coronavirus

PROJECT_TITLE: Antiviral innate immune responses to pathogenic coronaviruses in the nasal epithelium


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Cardiovascular;Clinical Research;Estrogen;Genetics;Heart Disease;Human Genome;Lupus;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Lupus is a systemic autoimmune disease that affects mainly women, but with disease severity worse in male lupus, with increased risk in developing cardiovascular disease. Our recent investigations into the role of monocytes in driving microvascular disease in female lupus has uncovered a link between altered metabolism in lupus monocytes and epigenetic remodeling, now recognized as a key player in development of cardiovascular disease. This proposal will how sex and gender specific differences in immunometabolism, regulation of gene expression contribute to monocyte function and how this correlates with cardiovascular involvement as determined by cardiovascular imaging.

PI_NAMEs: JEFFERIES, CAROLINE  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Affect;Angiography;Area;Autoimmune Diseases;Autoimmunity;Automobile Driving;Cardiac;cardiac magnetic resonance imaging;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular imaging;Cardiovascular system;Cause of Death;CD14 gene;Cholecalciferol;Chromatin;Coenzymes;Coronary;Coronary Arteriosclerosis;cytokine;Data;Development;Disease;disorder risk;Drug Targeting;Epigenetic Process;extracellular;FCGR3B gene;Female;Flow Cytometry;Functional disorder;Gender;gender difference;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;Genetic;Genetic Transcription;Glycolysis;heart imaging;high dimensionality;histone methylation;imaging approach;Imaging Techniques;Immune response;Immunization;Immunologic Memory;Inflammatory;Interferon alpha;Interferon Type I;Interferons;Investigation;Isocitrate Dehydrogenase;Libido;Link;Lupus;male;men;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Microvascular Dysfunction;Mitochondrial Proteins;monocyte;next generation sequencing;Organ;Outcome;Oxidative Phosphorylation;oxidized low density lipoprotein;Pathology;Pathway interactions;Patients;Phenotype;Prevalence;Production;programs;Proteomics;Publishing;Relative Risks;Research;response;Rheumatoid Arthritis;Risk;Role;Severity of illness;sex;Sex Bias;Sex Differences;sexual dimorphism;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Sun Exposure;Symptoms;systemic autoimmune disease;Systemic Lupus Erythematosus;Testing;Viral;Virus Diseases;Vitamin D;Woman;women patients

PROJECT_TITLE: Sex and gender differences in lupus - intersection between immunometabolism, epigenetic remodeling and cardiac involvement


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Relevance to Public Health. The number of people in the U.S. living with movement-related disabilities is staggering. Disability due to neurological disorders can often be mitigated by the careful application of electrical stimulation to specific neural structures. Both research and commercial applications related to neural stimulation are growing very rapidly, leading to a real need for highly qualified, Ph.D.-level engineers who have the technical and clinical backgrounds provided by this program.

PI_NAMEs: CAPADONA, JEFFREY R (contact);KIRSCH, ROBERT F.

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TITLE: Integrated Engineering and Rehabilitation Training


NIH_SPENDING_CATS: Cancer

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The central mission of the T32 “Molecular Imaging in Cancer Biology” (MICB) program will be to develop novel molecular imaging methods, technologies, and platforms that will accelerate the understanding of human cancer biology as a basis for designing curative cancer therapeutic regimens as well as cutting-edge diagnostic, prognostic, and therapeutic tools. The main objective of this T32 MICB training grant is to produce scientists who are highly trained in the fundamentals of molecular imaging. The proposed program will educate trainees in multiple aspects of molecular imaging and in the need for conversing and collaborating across a wide spectrum of disciplines.

PI_NAMEs: HRICAK, HEDVIG ;LEWIS, JASON S. (contact);OVERHOLTZER, MICHAEL H.

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Cancer Biology;molecular imaging;Training Programs

PROJECT_TITLE: Molecular Imaging in Cancer Biology Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: TOLEDO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

PHR: Project Narrative Borna disease virus 1 (BoDV-1), a nuclear-replicating non-segmented negative strand RNA virus, is a causative agent of fatal neurological diseases in animals and humans. Currently, the molecular mechanisms of transcription and replication of BoDV-1 remain largely unknown. The goal of this project is to elucidate the enzymatic and structural roles of the BoDV-1 RNA-dependent RNA polymerase subunits in RNA synthesis and processing.

PI_NAMEs: OGINO, TOMOAKI  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Amino Acids;Animals;Baculovirus Expression System;Biochemical;Biochemical Reaction;Bioinformatics;Biological Assay;Biology;Borna Disease;Borna virus;C-terminal;Cell Nucleus;Cells;cofactor;Complex;Cryoelectron Microscopy;Cytoplasm;Ebola;Elements;Encephalitis;Equus caballus;Evolution;Exhibits;Filovirus;Fossils;Genetic Transcription;Genome;Glycine decarboxylase;Goals;Guanine;Human;human pathogen;In Vitro;in vitro Assay;innovation;Insecta;Interferons;Messenger RNA;Methylation;Methyltransferase;Molecular;Mononegavirales;mRNA capping;Mutagenesis;Nervous System Disorder;Nipah;novel;Nuclear;Nuclear Proteins;Paramyxovirus;Play;Pneumovirus;Polymerase;Production;protein complex;Proteins;prototype;Rabies;Recombinants;Reporting;respiratory;Rhabdoviridae;RNA biosynthesis;RNA chemical synthesis;RNA Processing;RNA Viruses;RNA-Directed RNA Polymerase;Role;Sheep;Squirrel;Structure;System;Testing;therapeutic target;three dimensional structure;Time;tripolyphosphate;Vertebrates;Viral;Viral Genome;viral RNA;Virus;Virus Replication;Zoonoses

PROJECT_TITLE: Structure and function of Borna disease virus polymerase


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Genetics;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: PATHOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE This work is relevant to public health because placental abruption can kill the mother and the fetus or cause immediate and long-term health problems for babies born from pregnancies with abrupted placenta. In pregnancies with placental abruption, the mother is at risk of uncontrollable bleeding and the fetal complications include intrauterine growth restriction, low birth weight, stillbirth, spontaneous and medically required preterm delivery. The proposed research investigates novel cellular mechanisms that mediate the onset and development of placental abruption and thus advances NIH’s mission by finding ways to diagnose and treat the problem.

PI_NAMEs: SOOD, RASHMI  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Abruptio Placentae;activated protein C receptor;Acute;Animal Model;Antibodies;Birth;Blood coagulation;Blood Platelets;cell type;Cells;Chromatin Structure;Chronic;Classification;Coagulation Process;Cre lox recombination system;Data;Decidua;Dendritic Cells;Development;Diagnosis;Disease Progression;Endothelium;Enzymes;Evaluation;Event;Exhibits;fetal;Fetal Growth Retardation;Fetus;Flow Cytometry;Genetic;Goals;Health;Hematological Disease;Hemorrhage;high dimensionality;histone modification;Histones;Human;Immune;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;Injury;Ischemia;Knock-out;Knowledge;Label;Leucocytic infiltrate;Leukocytes;Life;Low Birth Weight Infant;Macrophage;maternal morbidity;Mediating;Mediator;Medical;Mission;Molecular;monocyte;mortality;Mothers;Mus;Natural Killer Cells;neutrophil;Neutrophil Infiltration;novel;Onset of illness;Outcome;Oxidants;Oxidative Stress;Pathogenesis;Pathology;perinatal morbidity;Perinatal mortality demographics;Peroxidases;pharmacologic;Phenotype;Placenta;Placentation;Platelet Activation;Play;Population;Post-Translational Protein Processing;Pregnancy;Pregnancy Complications;pregnant;Premature Birth;prevent;Process;Production;Public Health;Reaction;Receptor Activation;receptor expression;recruit;Research;Risk;Role;stillbirth;T-Lymphocyte;Testing;therapeutic target;Thrombin Receptor;Thrombophilia;Tissues;tool;trafficking;transcriptomics;United States National Institutes of Health;Uterus;Vascular Endothelium;Work

PROJECT_TITLE: Coagulation-inflammation crosstalk in placental abruption

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ORG_CITY: Aurora

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Public Health Relevance  This career development award will continue to support a highly productive program in patient-oriented research in dermatologic diseases at Harvard Medical School. The award with expand Dr. Asgari’s research portfolio to include patient-facing shared decision-making constructs while supporting her mentoring of trainees in patient-oriented research involving keratinocyte carcinogenesis. It will result in advances in the management of patients with skin diseases, especially those with skin cancer, through high quality patient-oriented research performed by well-trained clinical investigators and provide protected time for mentoring junior clinical investigators in patient-oriented research in dermatology.

PI_NAMEs: ASGARI, MARYAM MANDANA (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Address;Applications Grants;Award;cancer care;cancer initiation;carcinogenesis;care delivery;career;career development;catalyst;Clinical;Clinical Investigator;Data;Data Set;Dermatologic;Dermatology;Development;Development Plans;Diagnostic;dietary supplements;Disease;disease prognostic;Disease Progression;disorder risk;DNA;Educational Status;Environment;Environmental Risk Factor;Epidemiology;Epigenetic Process;epigenomics;experience;Faculty;Feedback;Foundations;Funding;Gene Combinations;Gene Expression;gene function;General Hospitals;Genetic;genome-wide;Genotype;Genotype-Tissue Expression Project;Goals;Growth;Individual;innovation;insight;Institution;Investments;K-Series Research Career Programs;keratinocyte;Knowledge;Laboratories;Leadership;Learning;Massachusetts;Measurement;medical schools;Medical Students;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);Modification;Mohs Surgery;Molecular;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;Outcome;parent project;Parents;Pathology;patient engagement;patient oriented;patient oriented research;Patient Self-Report;Patients;Peer Review;Peer Review Grants;Physicians;Play;Population;Positioning Attribute;Postdoctoral Fellow;Principal Investigator;Productivity;professor;prognostic indicator;programs;public health relevance;Publications;Research;Research Activity;Research Assistant;Research Personnel;Research Project Grants;research study;Research Support;Residencies;Risk;Role;Scientist;secondary analysis;shared decision making;skills;Skin Cancer;Skin Carcinogenesis;Skin Carcinoma;skin disorder;skin organogenesis;Structure;Surgeon;synergism;Time;Tissues;tool;Training;Training and Education;training opportunity;tumorigenesis;United States National Institutes of Health;Work

PROJECT_TITLE: Patient oriented research and mentoring program in dermatologic diseases

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE This project aims to establish next generation multimodal neuroimaging beyond current state-of-the-art technology by integrating multi-photon microscopy imaging and ultrahigh-resolution functional MRI (fMRI) methods at ultrahigh magnetic field. This novel neuroimaging technology will open new opportunities to address fundamental neuroscience and neuroimaging questions, and provide new insights into the neurophysiological basis of the fMRI signal and its specificity in mapping the laminar circuitry, neural dynamics and functional connectivity. Such knowledge will be highly transformative and represented in the mesoscopic- and macroscopic fMRI measurements of human brain function.

PI_NAMEs: CHEN, WEI  (contact);CUI, MENG ;ZHU, XIAO-HONG

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Ablation;Address;Affect;Anesthesia procedures;Animal Model;Animals;Astrocytes;awake;blood oxygen level dependent;Blood Vessels;Brain;Brain Diseases;brain research;Cells;Complex;Conscious;Correlation Studies;Data;Dedications;design;Disease;Functional disorder;Functional Magnetic Resonance Imaging;Generations;Goals;Health;hemodynamics;Human;Image;imaging system;Imaging Techniques;Imaging technology;Implanted Electrodes;Individual;inhibitory neuron;innovation;insight;Institution;Interneurons;Knowledge;Lasers;magnetic field;Magnetic Resonance Imaging;Maps;Measurement;Measures;Metabolic;Methods;Microscopic;microscopic imaging;Modality;multimodal neuroimaging;multiphoton imaging;multiphoton microscopy;Mus;Nerve;Nervous System;neural;neural circuit;neural network;neuroimaging;Neurons;neurophysiology;Neurosciences;Neurosciences Research;neurotransmission;neurovascular;new technology;next generation;novel;optical imaging;Outcome;Population;Positioning Attribute;pre-clinical;Process;Records;Research;Resolution;response;Rest;Role;Signal Transduction;spatiotemporal;Specificity;success;System;Techniques;Technology;Time;tool;two photon microscopy;ultra high resolution;Work

PROJECT_TITLE: Advancing simultaneous fMRI-multiphoton imaging technique to study brain function and connectivity across different scales at ultrahigh field

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: EDINBURG

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

PHR: PROJECT NARRATIVE A diverse biomedical science research workforce is vital to the nation in remaining globally competitive in scientific discovery and innovation. Through a partnership between three Hispanic-serving institutions, the University of Texas Rio Grande Valley, Texas Southmost College (TSC) and South Texas College (STC), this project will implement innovative, well- integrated strategies encompassing outreach and recruitment with career and program advising, courses for advanced research skill development, mentored-research experiences complement with other opportunities to develop research efficacy and skills and curriculum/methods development with academic enrichment which includes multi-level mentoring and academic and professional workshops. These program components/activities have been proposed to address the areas which have been identified through self-assessment that need to be improved and strengthened to enable underrepresented students to make a seamless transition from the participating community colleges to the bachelor's degree-granting institution and successfully complete the baccalaureate degree program in biomedical sciences.

PI_NAMEs: CHEW, SUE ANNE  (contact);GALVEZ, GRISELDA LOPEZ;MAHMOUDIAN-GELLER, MEHRZAD

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: academic preparation;Area;Associate Degree;Awareness;Biomedical Research;bridge to the baccalaureate;career;college;community college;community partners;Competence;County;Degree program;Diabetes Mellitus;experience;Goals;graduate school;health disparity;Healthcare;Hispanic Populations;illiteracy;improved;innovation;Institution;interest;matriculation;Mental Health;Mentors;Methods;Obesity;Pathway interactions;Population;Poverty;programs;recruit;Research;Research Training;Science;science education;Self Assessment;Services;skill acquisition;South Texas;Students;success;Texas;Training Programs;Underrepresented Students;Universities

PROJECT_TITLE: Bridges to the Baccalaureate Research Training Program at The University of Texas Rio Grande Valley

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Racial and Ethnic Minority Health Research;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative The time course to progress from compensated to decompensated cirrhosis varies based on many factors, including race/ethnicity, etiology of liver disease, and medical co-morbidities, and data suggest the time to progression may be slowed by administering statins (e.g., simvastatin). Our goal is to enroll a multi-ethnic cohort of patients with compensated cirrhosis in a longitudinal prospective cohort study, of which a subset with clinically significant portal hypertension will be enrolled in a randomized controlled trial of simvastatin, with a specific focus on genetic ancestry and HIV status.

PI_NAMEs: GOLDBERG, DAVID SETH (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Acceleration;Address;Admixture;African American;Age;Alcoholic Liver Diseases;Animal Model;Biological;Black Populations;Cessation of life;Cirrhosis;Clinical;clinical practice;Clinical Trials;clinically significant;cohort;Cohort Studies;comorbidity;Compensation;Data;Death Rate;demographics;Development;Disparity;elastography;Enrollment;Enzymes;Equation;Esophageal Varix;ethnic diversity;Ethnic Origin;Ethnic Population;Etiology;European;Event;Exposure to;Frequencies;Future;Genetic;genetic variant;Genetic Variation;Goals;Haplotypes;Hepatic;Hepatitis C Therapy;Hepatitis C virus;Hispanic;Hispanic Populations;HIV;Knowledge;Lipids;Liver diseases;liver stiffness;Measurement;Measures;Medical;Modeling;mortality;multi-ethnic;Native American Ancestry;nonalcoholic steatohepatitis;Outcome;Oxidoreductase;participant enrollment;Patient Self-Report;patient subsets;Patients;Pharmacogenomics;Population;Population Heterogeneity;Portal Hypertension;prevent;Primary carcinoma of the liver cells;Prospective Studies;Prospective, cohort study;Race;racial diversity;racial population;randomized, clinical trials;Randomized, Controlled Trials;Rattus;recruit;response;Risk;Safety;secondary analysis;Simvastatin;Socioeconomic Factors;Spain;Taiwan;Therapeutic;Thrombocytopenia;Time;Toxic effect;Underrepresented Populations;Variant;Veterans Health Administration;Viral hepatitis

PROJECT_TITLE: Evaluating the impact of genetic ancestry and HIV on cirrhosis progression and response to statin therapy among a diverse multi-ethnic cohort of patients with cirrhosis


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Cystic Fibrosis;Diabetes;Dietary Supplements;Lung;Nutrition;Obesity;Prevention;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Individuals with cystic fibrosis (CF), a life-threatening genetic disease, are enjoying longer lives; however, new research is critically needed to better understand the role of nutrition on long-term health outcomes in CF, including CF-related diabetes. This project will help to close this important knowledge gap in CF by determining if a low-added sugar dietary intervention can improve glucose tolerance by reducing visceral fat and reducing oxidative stress compared to a typical CF diet. The end goal of this study is to improve nutrition standard of care to optimize clinical outcomes and long-term quality of life for individuals with CF.

PI_NAMEs: ALVAREZ, JESSICA ALEJANDRA (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Achievement;Address;Adipose tissue;Adult;Age;aging population;aminothiol;Area;Arginine;Beta Cell;Body fat;Body mass index;Body System;burden of illness;Calories;Carbohydrates;Caring;Cell Physiology;Clinical;clinical care;Clinical Trials Cooperative Group;Closure by clamp;Communities;Consumption;Control Groups;Cysteine;Cystic Fibrosis;cystic fibrosis patients;cystic fibrosis related diabetes;Cystine;Data;Deposition;design;Development;Diabetes Mellitus;diabetes risk;Diet;Diet Modification;dietary;dietary approach;dietary excess;Dietary Intervention;Dietary Sugars;Disulfides;Double-Blind Method;Endocrine system;Equilibrium;evidence base;extracellular;Fatty acid glycerol esters;feeding;Food;gastrointestinal system;General Population;Genetic Diseases;Glucose;Glucose Intolerance;glucose tolerance;Goals;Guidelines;Health;High Fat Diet;high risk;Homeostasis;Hyperglycemia;Image;Impairment;improved;Individual;insight;Insulin Resistance;insulin secretion;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Intervention;Knowledge;Life;Life Style;Link;liquid chromatography mass spectrometry;Liver;Macronutrients Nutrition;Magnetic Resonance Imaging;Malnutrition;Measures;Mediator;Medical;Metabolic;Metabolic Pathway;metabolomics;Modification;Muscle;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Nutritional;Nutritional Study;Outcome;Oxidation-Reduction;Oxidative Stress;Pancreas;Participant;Pathogenesis;Pathway interactions;Persons;Pharmacotherapy;Phase;Plasma;Population;Precipitating Factors;Prediabetes syndrome;prevent;Prevention;Quality of life;Randomized;recessive genetic trait;Recommendation;Research;Research Priority;Resolution;Role;Spectrum Analysis;standard of care;Strategic Planning;success;sugar;Testing;Thigh structure;Translating;type I and type II diabetes;United States National Institutes of Health;Visceral;Visceral fat;Weight Gain;Work

PROJECT_TITLE: A Dietary Intervention to Improve Glucose Tolerance in Adults with Cystic Fibrosis

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Opioids;Pain Research;Palliative Care;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Effective pain management is a core element of advanced cancer treatment, as under-treated pain is associated with adverse health consequences and suboptimal quality of life. Cancer-related pain is commonly managed with prescription opioids; however, patients with advanced cancer experience unique challenges associated with this strategy due to the opioid crisis, including stigma surrounding prescription opioid use (“opioid stigma”). The project described in this NCI K08 application will develop and pilot test an intervention to address opioid stigma in patients with advanced cancer, which can then be tested in a randomized controlled trial.

PI_NAMEs: BULLS, HAILEY WADDELL (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acceptability and feasibility;addiction;Address;adherence rate;Advanced Malignant Neoplasm;Adverse event;adverse outcome;Area;Assertiveness;Award;Behavior;Behavior Therapy;Behavioral;Cancer Center;cancer pain;Cancer Pain Management;cancer therapy;career;career development;Caregivers;Caring;Cessation of life;Characteristics;Client satisfaction;Clinical Practice Guideline;Communication;Communication difficulty;Communities;community intervention;concept mapping;Conduct Clinical Trials;Coping Skills;Data;Dedications;design;Development;Disparity;efficacy testing;efficacy trial;Elements;emotional distress;Enrollment;experience;Feedback;Foundations;Fright;Future;Health;Health behavior;health related quality of life;high risk;Impairment;improved;innovation;internalized stigma;Intervention;Intervention Trial;Label;Link;Literature;Malignant Neoplasms;Mentors;Mentorship;Methodology;Mission;multidisciplinary;Not Hispanic or Latino;novel;Oncology;Opioid;Opioid Analgesics;opioid epidemic;opioid policy;opioid use;Outcome;Outcome Assessment;Overdose;Pain;Pain management;Pain quality;palliative;Participant;patient engagement;patient-clinician communication;Patients;people of color;Personal Satisfaction;Persons;pilot test;pilot trial;post intervention;Preparation;prescription opioid;primary outcome;Principal Investigator;Process;Publishing;Qualitative Research;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Methodology;Research Personnel;Resources;rural area;skills;social;social cognitive theory;Social isolation;social stigma;Stereotyping;Stress and Coping;Surveys;Symptoms;Testing;theories;therapy development;tool;Training;treatment as usual;underserved community;Underserved Population;United States;Woman

PROJECT_TITLE: Development and piloting of an intervention to reduce the impact of opioid stigma in cancer pain

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Biomedical Imaging;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Unlike the vast majority of computational tools that are developed for adult brain MRI with good image con- trast, this project will empower neuroscience researchers with robust tools needed to quantify temporal structural changes in the early developing brain, including tools for (i) Uniﬁed longitudinal analysis of volumetric and surface data of infant MRI; (ii) Multimodal parcellation with longitudinal and intersubject consistency; (iii) Deep learning prediction of missing data. The tools developed will be disseminated in the form of a software package complete with documentation and tutorials. As part of this project, we will deliver the ﬁrst set of temporally-dense surface- volumetric atlases that will capture key developmental traits, critical for quantiﬁcation of possible deviation from normal brain development.

PI_NAMEs: YAP, PEW-THIAN  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 5 year old;Address;Adult;aging brain;analysis pipeline;Appearance;Atlases;Award;Birth;Brain;Brain Diseases;brain magnetic resonance imaging;Cerebral cortex;Childhood;Communities;Computer software;computerized tools;connectome;contrast imaging;critical period;Data;Data Set;Dedications;deep learning;design;Development;Diffusion Magnetic Resonance Imaging;Dimensions;Documentation;Dropout;empowerment;Evolution;Exhibits;Failure;Functional Magnetic Resonance Imaging;Funding;Goals;Growth;Human;Image;image registration;imaging modality;improved;Infant;Joints;Libraries;Life;life span;longitudinal analysis;Longitudinal Studies;Magnetic Resonance Imaging;Maps;Measurement;Methods;Minnesota;multimodality;Neurodevelopmental Disorder;Neurosciences;North Carolina;Outcome;Pattern;predictive tools;Request for Proposals;Research Personnel;Research Support;Sample Size;Sampling;Scanning;Statistical Data Interpretation;Structure;Surface;Techniques;Thinness;Time;tool;trait;Universities;usability;white matter

PROJECT_TITLE: Longitudinal Mapping of Human Brain Development in the First Years of Life


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Understanding mechanisms of Leydig cell regeneration has major implications for improving therapies for male health and infertility due to the loss and quiescence of Leydig cells with age. This work will contribute significantly to the understanding of regeneration in adult tissues in general. As a result, it will add to the understanding of the origins of many cancers and also improve strategies for tissue regeneration in living organisms.

PI_NAMEs: JEFFERY, JASMIN LAKIA (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Ablation;Adult;Age;Aging;Alkanesulfonates;Androgens;Automobile Driving;Biology;Candidate Disease Gene;candidate marker;candidate selection;Cell Cycle;Cell Death;Cell Proliferation;cell regeneration;Cell Separation;cell type;Cells;Characteristics;Chemicals;Cre driver;Cytotoxic agent;Data;Development;differential expression;Ethane;extracellular;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Germ Cells;Goals;Growth;improved;In Vitro;in vivo regeneration;inhibitor;injured;Injury;interest;Interphase Cell;leydig interstitial cell;male;male fertility;male health;Male Infertility;Malignant Neoplasms;men;Modeling;Molecular;Monitor;mouse genetics;Mus;Natural regeneration;novel;Organ;Organism;Pathway interactions;Personal Satisfaction;pharmacologic;Physiological;Population;precursor cell;Process;progenitor;Rattus;regeneration model;regenerative;regenerative cell;Regenerative research;repaired;response;response to injury;Role;self-renewal;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule;Somatic Cell;Source;sperm cell;stem cells;Supporting Cell;System;Testing;Testis;Tissue Model;tissue regeneration;Tissues;tool;transcriptome;transcriptomics;Work

PROJECT_TITLE: Molecular Mechanisms of Leydig Cell Regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]


NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation

ORG_CITY: WHITE PLAINS

ORG_NAME: WINIFRED MASTERSON BURKE MED RES INST

ORG_STATE: NY

PHR: PROJECT NARRATIVE Unilateral spastic cerebral palsy is an extremely common pediatric neurological disorder of movement, and existing efficacious therapies are time intensive and costly. Non-invasive brain stimulation, aiming to influence the excitability of the brain in the area that controls movement, may enhance physical rehabilitation approaches. This study will examine the combined effects of non-invasive brain stimulation and hand movement therapy in children with unilateral spastic cerebral palsy, and will inform future precision- interventions aiming to increase availability and decrease cost of treatment.

PI_NAMEs: GORDON, ANDREW M.;RATNADURAI GIRIDHARAN, SHIVAKESHAVAN  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Activities of Daily Living;Adoption;Adult;Affect;Anodes;Area;Brain;Cerebral Palsy;Child;Childhood;Clinical;constraint induced movement therapy;Contralateral;Corticospinal Tracts;cost;Data;Development;dosage;effective intervention;Effectiveness;efficacious treatment;efficacy evaluation;evidence base;Family;Financial cost;Funding;Future;Goals;Hand;Hand functions;Handedness;hemisphere damage;Heterogeneity;Hour;Impairment;improved;Individual;innovation;Ipsilateral;Lead;Learning;low socioeconomic status;Manuals;Maps;Measures;Methods;Motor;motor control;Motor Cortex;motor impairment;Movement;Movement Disorders;Muscle;Nervous System Disorder;neural;Neuronal Plasticity;noninvasive brain stimulation;novel;Outcome;Pathway interactions;Pediatric Brain Injury;personalized approach;personalized intervention;Physical Rehabilitation;Physiologic pulse;Physiology;Randomized;randomized, clinical trials;Rehabilitation therapy;Research;Resources;response;Side;skills;Spastic Cerebral Palsy;Stroke;Testing;Time;Training;transcranial direct current stimulation;Transcranial magnetic stimulation;Treatment Cost;Treatment Efficacy;Upper Extremity;Work

PROJECT_TITLE: Targeted transcranial direct current stimulation combined with bimanual training for children with cerebral palsy

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_CITY: ROCHESTER

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Suicide is the tenth leading cause of death in the U.S., second among individuals between the ages of 10 and 34 and fourth among individuals between the ages of 35 and 54. Rates of suicide have increased by over 30% in the past two decades and continue to rise. The objective of this postdoctoral fellowship is to provide scientists with the knowledge and skills to design and conduct research with the goal of reducing suicide- related morbidity and mortality across the life course.

PI_NAMEs: VAN ORDEN, KIMBERLY ALLISON (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: post-doctoral training;Prevention Research;Suicide prevention

PROJECT_TITLE: Postdoctoral Training in Suicide Prevention Research