NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Enterovirus D68 (EV-D68) has been implicated in severe respiratory illness and acute flaccid myelitis (AFM), a polio-like illness causing paralysis in previously healthy children. There are no specific treatments for AFM, most children are left with residual deficits, and it is currently unknown how EV-D68 targets the central nervous system. The goal of this proposal is to identify how EV-D68 mediates cellular damage in the human spinal cord by using an innovative human spinal cord organoid model.

PI_NAMEs: FREEMAN, MEGAN CULLER (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 3-Dimensional;Achievement;Acids;acute flaccid myelitis;Advisory Committees;Antibodies;Basic Science;Biological Assay;Biological Models;bronchial epithelium;career development;cell injury;Cell Line;Cell Lineage;Cell model;cell type;Cells;Cellular biology;Cellular Tropism;Central Nervous System;Central Nervous System Infections;Cerebrospinal Fluid;Cessation of life;Child;Childhood;Circulation;clinical training;Collaborations;Communicable Diseases;Coronavirus Infections;Coxsackie Viruses;CSF3 gene;cytokine;Cytolysis;Data;Disease;disease phenotype;Doctor of Philosophy;Echo Viruses;Encephalitis;Enterovirus;Enterovirus 68;Enterovirus 71;Enterovirus Infections;Environment;Epithelial Cells;Epithelium;excitotoxicity;experience;experimental study;Family;Foundations;Funding;Genes;Genetic Drift;Genetic Variation;Glutamate Transporter;Glutamates;Goals;HIV;Human;human model;human tissue;Imaging Techniques;Immune;Immune response;Immunity;Immunologics;Immunology;Induced Neurons;Infection;Inflammatory Response;Injury;Innate Immune Response;innovation;Interferons;Intestines;Intramuscular Injections;Investigation;Kinetics;Knowledge;Left;Location;Mammals;Measles;Mediating;Medical center;medical schools;member;Mentors;Mentorship;Modeling;Motor Neurons;multidisciplinary;Mus;National Institute of Allergy and Infectious Disease;Natural Immunity;neonatal mice;Nervous System;Neurodegenerative Disorders;neuromechanism;Neuronal Injury;Neurons;Neurosciences;Neurotransmitters;novel;novel virus;oral communication;Organoids;Paralysed;Pathogenesis;Pathway interactions;Patients;Pediatric Hospitals;pediatrician scientist;Pediatrics;Physicians;Physiological;Poliomyelitis;prevent;programs;Research;Residual state;Resources;respiratory;Respiratory System;respiratory virus;response;responsible research conduct;RNA;Route;Sampling;Scientist;Site;skills;Specificity;Spinal;Spinal Cord;Stomach;symposium;Syndrome;Technical Expertise;Techniques;Temperature;therapeutic target;timeline;Tissue imaging;Tissue Model;Tissues;Training;Transcript;Universities;Viral;Viral Pathogenesis;Virus;Virus Diseases;Virus Replication;Work;Writing

PROJECT_TITLE: Investigation of enterovirus D68 pathogenesis in the human spinal cord

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

ORG_CITY: BAR HARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PI_NAMEs: PHILIP, VIVEK  (contact)

PROJECT_TERMS: addiction;Algorithms;Behavior;behavior test;Behavioral;Behavioral Genetics;behavioral phenotyping;biobank;biobehavior;bioinformatics pipeline;Biological;Brain;causal variant;Chromosome Mapping;Code;cohort;combinatorial;Communities;Complex;Data;data access;data acquisition;Data Analyses;data dissemination;data integration;data management;data quality;data quality/integrity;data reuse;Detection;differential expression;Disease;Education and Outreach;Ensure;experience;Experimental Designs;Exposure to;Fostering;Gene Expression;Genes;Genetic;genetic analysis;genetic approach;genetic resource;Genetic study;Genome;genome resource;genome-wide;genomic data;Genomics;Genotype;Goals;Human;Impulsivity;in vivo;Inbreeding;innovation;interoperability;Laboratory mice;meetings;member;Methods;Modernization;Molecular;Molecular Analysis;molecular phenotype;Mus;neurobiological mechanism;Neurobiology;neurogenetics;novel;novel strategies;Outcomes Research;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;phenotypic data;Play;polysubstance use;Population;Population Genetics;Predisposition;Procedures;Process;programs;Protocols documentation;quality assurance;Quality Control;Quantitative Trait Loci;Reproducibility;Research;Research Personnel;Resource Development;Resources;Risk;Role;Sampling;Self Administration;Services;skill acquisition;Source;Statistical Data Interpretation;stimulant dependence;Structure;System;Tissues;tool;Training;trait;Untranslated RNA;Validation;Variant;Visualization;whole genome

PROJECT_TITLE: Integrative Genetics and Genomics Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: GAGNON, LEONA  (contact)

PROJECT_TERMS: addiction;Adopted;Animal Experimentation;Behavior;Behavior assessment;behavior test;Behavioral;Behavioral Assay;behavioral phenotyping;biobank;Biological;Biological Assay;Biometry;Cocaine;cocaine self-administration;cohort;Collaborations;Communities;Complex;Core Facility;cost effective;Darkness;Data;Data Analyses;data integration;Data Set;Databases;Dimensions;Dose;drug sensitivity;Engineering;Ensure;exceptional responders;Extinction;Food;Funding;Genes;Genetic;genetic analysis;genetic information;Genetic study;Genomics;Goals;Human Resources;Impulsivity;Inbreeding;Incentives;indexing;Individual Differences;Investigation;Laboratories;Laboratory mice;Life;Light;Methods;model organism;Mus;neurogenetics;novel;operation;Pharmaceutical Preparations;Phase;phenome;Phenotype;Pilot Projects;Population;Predisposition;preference;Procedures;Protocols documentation;public repository;Punishment;Quality Control;Reproducibility;Research;Research Personnel;Resources;response;Rewards;Risk Taking;Role;Science;Self Administration;Services;System;Testing;Tissue Banks;Tissue Sample;Training;trait;Validation;Variant;Work

PROJECT_TITLE: Behavioral Phenotyping Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Behavioral and Social Science;Biotechnology;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Nutrition;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Measures of subclinical atherosclerosis assessed by CT provide predictive information for risk of coronary events independent of traditional cardiovascular disease (CVD) risk factors. This study will address critical gaps in current scientific knowledge on the presence/absence and extent of coronary artery calcium (CAC), and plaque volume, density, and distribution in diverse US Hispanic/Latino heritage groups, and will examine relationships with sociocultural characteristics, lifestyle factors, traditional CVD risk factors, and epigenomic patterns. Findings from this study will help identify novel preventive targets and inform development of precision prevention/ treatment strategies that may benefit all racial/ethnic groups.

PI_NAMEs: BUDOFF, MATTHEW J;DAVIGLUS, MARTHA L (contact);GALLO, LINDA C;HOU, LIFANG

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: Accounting;Acculturation;Adult;Agatston Score;Age;American;American Heart Association;Ancillary Study;Archives;Atherosclerosis;Biological;Biological Markers;Blood;Calcium;Cardiac;Cardiology;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Characteristics;Chicago;Cholesterol;cigarette smoking;Clinical;cohesion;cohort;college;Communities;Coronary;Coronary Arteriosclerosis;coronary artery calcium;coronary event;Coronary heart disease;cost effective;critical period;Cuban;Data;Decision Making;density;Detection;Development;Diabetes Mellitus;Diet;DNA;DNA Methylation;Dominican;early detection biomarkers;Economic Conditions;Epidemiology;epigenetic marker;Epigenetic Process;epigenomic profiling;epigenomics;ethnic identity;Ethnic Population;Etiology;Event;Exposure to;Family;follow-up;Genetic;genome sequencing;Genomics;Guidelines;Health;high dimensionality;Hispanic;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;hypercholesterolemia;Hypertension;individualized prevention;Infrastructure;Knowledge;Language;Latino;Latino Population;Life Expectancy;Life Style;lifestyle factors;Link;Longitudinal Studies;Low Prevalence;Maps;Measures;Mediation;men;Mendelian randomization;Methylation;methylation biomarker;Mexican;mortality;National Heart, Lung, and Blood Institute;National origin;Not Hispanic or Latino;novel;Obesity;Participant;Pattern;Physical activity;Population;Population Heterogeneity;Population Study;Prevalence;Prevention;Prevention strategy;Preventive;Process;prospective;Prospective Studies;protective factors;Puerto Rican;Quantitative Trait Loci;racial population;Random Allocation;Recording of previous events;residence;Resources;Risk;Risk Factors;Role;Sampling;Scanning;social culture;Social support;sociocultural determinant;socioeconomic adversity;socioeconomics;South American;specific biomarkers;Time;tool;Trans-Omics for Precision Medicine;treatment strategy;Variant;Visit;whole genome;Woman

PROJECT_TITLE: Coronary Artery Calcium and its Association with Protective/Risk Factors and Epigenetic Patterns in Diverse US Hispanic/Latino Adults

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative Our research concerns fundamental questions about the basic mechanisms responsible for cell polarity (the development of asymmetric cell behaviors along one or more axes) in eukaryotic cells, and how such polarity is regulated. Cell polarity enables cell migration and directed cell growth, both of which are critical to organismal development. Dysregulated cell migration and cell shape contribute to various aspects of disease including metastatic malignancy.

PI_NAMEs: LEW, DANIEL J (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Back;cell behavior;Cell Cycle;Cell Cycle Regulation;cell growth;cell motility;Cell Nucleus;Cell Polarity;Cell Shape;cell type;Cells;Cellular biology;Chemicals;Complex;Computer Models;Development;Disease;Environment;Eukaryotic Cell;Event;Feedback;fungus;Genetic Models;Goals;Grant;insight;Instruction;interest;Life Style;Malignant Neoplasms;marine;Medical;Microscopy;Neoplasm Metastasis;novel;Organelles;Partner in relationship;Pheromone;Regulation;Research;response;Shapes;Signal Transduction;Site;Specific qualifier value;System;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Studies on cell polarity, chemotropism, and cell cycle control

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Substance Misuse

PI_NAMEs: REINHOLDT, LAURA G (contact)

PROJECT_TERMS: addiction;Alleles;Archives;Area;Behavioral;behavioral phenotyping;Biological Assay;Biology;Breeding;Candidate Disease Gene;candidate validation;Cell Line;Cellular biology;cohort;Communities;Complex;cost;Credentialing;CRISPR/Cas technology;Data;Data Analyses;data integration;Derivation procedure;disease model;Engineering;Ensure;experience;Funding;Genes;Genetic;Genetic Engineering;genetic information;Genetic Research;genetic resource;Genetic Variation;Genetically Engineered Mouse;Genomics;Geographic Locations;Haplotypes;Health Status;in vitro Model;in vivo;Inbreeding;Information Resources;Infrastructure;innovation;Institution;Knock-in;Knowledge;Laboratories;Laboratory mice;Legal;Methods;Mission;model development;Modeling;Molecular Genetics;mouse genetics;mouse model;Mouse Strains;Mus;neurogenetics;Nomenclature;novel;overexpression;Pharmaceutical Preparations;Phase;Phenotype;Population;Production;programs;Quarantine;repository;Reproducibility;Research;Research Project Grants;Research Support;Resource Sharing;Resources;Risk;Self Administration;Site;Source;Standardization;Study models;System;The Jackson Laboratory;tool;trait;United States National Institutes of Health;Validation;Variant;Vendor;Work

PROJECT_TITLE: Mouse Resources and Validation Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Physical Activity;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: College Station

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: PROJECT NARRATIVE Individuals living in rural settings, particularly medically underserved areas, are at increased risk for cancer and other chronic diseases; factors such as socioeconomic disadvantage, geographical distances/barriers, social and cultural issues, and limited access to healthcare, healthy foods, and/or physical activity opportunities contribute to this health inequity. Civic engagement for built environment change (CEBEC) interventions hold promise in catalyzing local built environment and policy changes to support healthy eating and active living in rural areas. The Change Club is a resident-led CEBEC strategy that will be implemented by extension educators and co-led by residents in eight medically underserved rural communities; it will provide an innovative model for addressing rural health equity in the intervention communities as well as the potential for broad public health impact in other underserved rural areas through national dissemination.

PI_NAMEs: SEGUIN-FOWLER, REBECCA ANNE (contact)

PROGRAM_OFFICER_NAME: BERRIGAN, DAVID

PROJECT_TERMS: Accelerometer;active lifestyle;Address;Affect;Area;Attitude;Behavior;behavior change;behavioral outcome;Belief;Biochemical;Blood Pressure;Body mass index;built environment;cancer risk;cancer type;Cardiovascular Diseases;cardiovascular risk factor;Carotenoids;Cholesterol;Chronic Disease;cohesion;Communities;Community Health;community intervention;cost;Cost Analysis;cost comparison;cost effective intervention;cost effectiveness;Data;Dermal;design;Development;Diabetes Mellitus;Diet;Diffusion;Disease;Eating;Educational workshop;effective intervention;empowerment;Ensure;Environment;environmental change;Environmental Risk Factor;Evaluation;Event;Exercise;Exposure to;Face;Focus Groups;fruits and vegetables;Future;Geography;Glucose;Glycosylated hemoglobin A;Goals;Health;Health behavior;Health behavior and outcomes;health care availability;health data;health equity;Health Food;health inequalities;Health Insurance;Healthcare;Healthy Eating;implementation barriers;implementation facilitators;improved;Individual;innovation;insight;Intake;Intervention;Knowledge;Location;Malignant Neoplasms;Measures;medically underserved;Medically Underserved Area;member;Methods;Modeling;nutrition;Obesity;Outcome;Outcome Measure;overweight adults;Participant;Pathway interactions;Persons;Physical activity;physical inactivity;Pilot Projects;Policies;Population;population health;Poverty;primary outcome;Process;process evaluation;Public Health;public health priorities;randomized trial;recruit;Resources;Risk;Risk Factors;Rural;rural area;Rural Community;rural dwellers;rural health disparities;Rural health equity;rural setting;Sampling;Science;secondary outcome;Self Efficacy;Site;Smoking;social;social capital;social cohesion;social factors;Social Network;social norm;socioeconomic disadvantage;Source;Speed;success;Surveys;symposium;Time;tool;Training;underserved rural area;Unhealthy Diet;webinar;Work

PROJECT_TITLE: Evaluation of a Civic Engagement Approach to Catalyze Built Environment Changeand Promote Healthy Eating and Physical Activity Among Rural Residents

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: JENTSCH, J. DAVID  (contact)

PROJECT_TERMS: Abstinence;Acute;addiction;addiction liability;Affect;Animal Model;Behavior;Behavior Control;behavior influence;behavior prediction;behavioral phenotyping;biobehavior;Biological;Brain;Candidate Disease Gene;Chromosome Mapping;Clinical;Cocaine;cocaine self-administration;Collaborations;combinatorial;Computer Models;Consumption;Data;Data Set;design;Dissection;drug of abuse;Drug usage;Engineering;Exhibits;experience;Funding;Gene Expression;gene network;Genes;Genetic;genetic analysis;Genetic Engineering;Genetic Variation;Genetically Engineered Mouse;genome wide association study;Genomics;Goals;Hand;Heritability;Human;human model;Impairment;Impulsive Behavior;Impulsivity;Incentives;Individual Differences;insight;Investigation;Learning;Link;Measures;Mediating;Modeling;Molecular;Motivation;mouse model;Mus;neurobehavioral;neurobiological mechanism;Neurobiology;neurochemistry;neurogenetics;neuromechanism;neuropsychiatry;novel;Pattern;Pharmaceutical Preparations;Phenotype;phenotypic data;Population;Population Heterogeneity;Predisposition;Process;Psychological reinforcement;Quantitative Trait Loci;Recreation;Reporting;Research Personnel;Resources;response;Reversal Learning;Rewards;Risk Factors;Role;Sampling;segregation;Self Administration;Stimulant;synergism;System;Testing;Tissue-Specific Gene Expression;trait;trait impulsivity;Validation;Variant;Work

PROJECT_TITLE: Project 1: Impulsivity


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PHR: PROJECT NARRATIVE Infection with Mycobacterium tuberculosis (Mtb) caused 10 million new cases of active tuberculosis (TB) disease and 1.5 million deaths, in 2019, making TB the leading cause of death in the world by a single infectious agent. The long treatment duration, spectrum of clinical outcomes, high disease relapse, and emergence of drug resistance are all complications of TB treatment attributable to the intrinsic heterogeneity of the disease. Strategies developed in this project will accelerate development of multidrug regimen that will be efficacious against heterogeneous drug tolerant subpopulations of Mtb, achieving faster clearance and lowering the likelihood for evolution of resistance.

PI_NAMEs: BALIGA, NITIN S (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Acceleration;Adopted;Algorithms;Biochemical Pathway;biomarker panel;Bioreactors;Cause of Death;Cells;Cessation of life;Characteristics;Chemicals;Clinical;combinatorial;Communicable Diseases;Complex;CRISPR interference;Cues;Development;Disease;disease heterogeneity;Drug Combinations;Drug resistance;Drug Targeting;Drug Tolerance;emerging antimicrobial resistance;Environment;Essential Genes;Evolution;Experimental Designs;Gene Expression Profile;Genetic;Genetic Transcription;Growth;Heterogeneity;Infection;Infectious Agent;Intervention;Machine Learning;Macrophage;Malignant Neoplasms;Metabolic;Modeling;Mycobacterium tuberculosis;network models;new technology;new therapeutic target;novel;novel drug combination;Outcome;pathogen;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiologic tolerance;Physiological;Physiological Adaptation;Population;Population Heterogeneity;Predisposition;Progress Reports;promoter;Publications;Recurrent disease;Regimen;Reporting;Resistance;Resolution;response;Sorting;Structure;support network;System;Systems Analysis;Systems Biology;Techniques;Technology;Testing;Time;transcription factor;transcriptome;treatment duration;Tuberculosis;tuberculosis drugs;tuberculosis treatment

PROJECT_TITLE: A systems analysis of drug tolerance in Mycobacterium tuberculosis

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: TARANTINO, LISA M (contact)

PROJECT_TERMS: Acute;addiction;Animal Model;base;Behavior;Behavioral;Behavioral Mechanisms;behavioral phenotyping;behavioral sensitization;behavioral study;Biological;Biological Assay;Biological Models;Candidate Disease Gene;candidate validation;Chromosome Mapping;Chronic;Clinical Research;Cocaine;cocaine self-administration;cocaine sensitization;cocaine use;Cocaine use disorder;Collaborations;Complement;Data;disease model;disorder risk;Dose;Drug Addiction;Drug Exposure;Drug Kinetics;drug of abuse;Drug usage;Engineering;Ethical Issues;Etiology;Evaluation;Exhibits;Exposure to;Funding;Gene Expression Profiling;gene function;Genes;Genetic;Genetic Engineering;Genetic study;Genetically Engineered Mouse;genomic data;Genomics;Goals;High Pressure Liquid Chromatography;high throughput screening;Human;Hypersensitivity;Impulsivity;Incentives;Individual;Individual Differences;individual variation;insight;Knock-out;Knowledge;Maps;Measures;Mediating;Modeling;Motivation;Mus;neuroadaptation;Neurobiology;neurogenetics;overexpression;Pathway interactions;Pattern;Periodicity;Persons;Pharmaceutical Preparations;Phenotype;phenotypic data;Population;Predisposition;Property;public database;Quantitative Trait Loci;Recording of previous events;Regimen;Relapse;Reporting;Research;Resources;response;reward circuitry;Rewards;Rodent;Role;Scanning;Self Administration;stimulant exposure;Stimulus;success;System;Testing;Tissues;uptake;Validation;Variant

PROJECT_TITLE: Project 2: Acute Cocaine Sensitivity and Chronic Sensitization


PI_NAMEs: CHESLER, ELISSA J (contact)

PROJECT_TERMS: Acute;addiction;addiction liability;Anatomy;Animals;Behavior;Behavior assessment;Behavioral;behavioral phenotyping;biobehavior;Biological;Biological Assay;Candidate Disease Gene;candidate identification;Cocaine;cocaine self-administration;cocaine sensitization;Collaborations;Communities;Complex;Computing Methodologies;Data;Data Correlations;data resource;drug maintenance;drug seeking behavior;Drug usage;Engineering;experience;Extinction;Female;functional genomics;Future;Gene Expression;gene network;Genes;Genetic;genetic analysis;genetic resource;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;genomic data;Genomics;Heritability;Human;improved;Impulsivity;In Situ;In Situ Hybridization;Inbred Mouse;Individual Differences;insight;Intake;Intravenous;male;Maps;Measures;Mediating;Molecular;Motivation;mouse genetics;mouse model;Mouse Strains;Mus;Mutant Strains Mice;Nature;neurobiological mechanism;Neurobiology;neurogenetics;Pathway interactions;Pharmaceutical Preparations;Population;Population Genetics;Population Heterogeneity;pre-clinical research;preference;Prevention;Protocols documentation;Punishment;Quantitative Trait Loci;Recombinant Inbred Strain;Research Support;Resources;response;Rest;Rewards;Risk;Risk Factors;Risk Taking;Rodent;Self Administration;sex;Statistical Methods;Substance Use Disorder;System;Technology;trait;Transcriptional Regulation;Variant

PROJECT_TITLE: Project 3: Cocaine IVSA


ORG_CITY: SHREVEPORT

ORG_DEPT: PATHOLOGY

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: PROJECT NARRATIVE The CoBRE Center for Redox Biology and Cardiovascular Disease will provide a unique training and research environment for junior investigators to receive mentorship and guidance, while increasing their competitiveness for major research funding through national grant program opportunities. The Center will advance new insights and understanding of redox biology control of heart and vascular disease processes that may lead to new and better ways to detect or treat cardiovascular disease.

PI_NAMEs: KEVIL, CHRISTOPHER G (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Achievement;Address;Advisory Committees;Affect;Animal Model;Antioxidants;Area;Biology;Blood Vessels;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular system;Cause of Death;Centers of Research Excellence;Cessation of life;cohort;Core Facility;Country;Development;disability;Disease;education research;Environment;Equilibrium;Extramural Activities;Faculty;faculty research;Functional disorder;Funding;Future;Goals;Grant;Growth;Health;Heart;Heart Diseases;Histology;Individual;insight;Institution;Knowledge;Leadership;Louisiana;meetings;Mentors;Mentorship;Molecular;Molecular Biology;molecular pathology;Morbidity - disease rate;mortality;oxidant stress;Oxidation-Reduction;Participant;Pathway interactions;Persons;Phase;Play;Policies;Process;Productivity;Program Development;programs;recruit;Regulation;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;Role;Scientific Advances and Accomplishments;Signal Transduction;Teacher Professional Development;Training;Training Programs;United States;Vascular Diseases


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease

PROJECT_TERMS: Achievement;Advisory Committees;Area;Biology;Budgets;Businesses;Cardiovascular Diseases;Cardiovascular system;Communication;Consult;Continuing Education;Core Facility;Development;Education;education research;Eligibility Determination;Evaluation;Event;Faculty;faculty research;Functional disorder;Funding;Goals;Grant;Growth;Health;Individual;Institution;International;Leadership;Link;meetings;member;Mentors;Mentorship;Monitor;National Institute of General Medical Sciences;Oxidation-Reduction;Policies;Principal Investigator;Procedures;Program Development;programs;recruit;Report (document);Reporting;Research;Research Personnel;Research Project Grants;Resources;Science;Services;Teacher Professional Development;Training;Training Programs;web page;web site

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE From a sample of 272 male-female couples (544 individuals, 272 men and 272 women) recruited from rural KaZulu-Natal, South Africa, couples will be randomized to receive either individual a package of dyadic counseling and testing (intervention arm) or an attention matched control. The research examines the impact of a package of dyadic counseling and testing on viral suppression and engagement in HIV care among sero- discordant and concordant positive male-female couples in KwaZulu-Natal, South Africa.

PI_NAMEs: DARBES, LYNAE A (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Address;Adherence;Adult;AIDS prevention;antenatal;Attention;Behavioral;Caring;Characteristics;Clinic;Continuity of Patient Care;Control Groups;Counseling;Country;Couples;Disclosure;Educational Curriculum;efficacy evaluation;efficacy testing;Epidemic;Female;female couples;Goals;Heterosexuals;High Prevalence;HIV;HIV Seropositivity;Human immunodeficiency virus test;improved;Individual;Infection;innovation;Intervention;intervention effect;Learning;Life Expectancy;Link;Literature;male;male couples;Mediating;men;motivational enhancement therapy;novel;Outcome;Phase;Prevalence;Prevention;preventive intervention;Problem Solving;Professional counselor;Qualitative Methods;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Research;Risk;Risk Reduction;Rural;Rwanda;Sampling;Sexual Partners;sexual risk behavior;Site;South Africa;Techniques;Testing;Training;transmission process;treatment arm;trial design;uptake;Viral;Woman;Work;Zambia

PROJECT_TITLE: HIV prevention and care for couples in South Africa

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Physical Activity

PI_NAMEs: STOKES, KAREN Y (contact)

PROJECT_TERMS: Address;Animal Model;Animals;Area;Awareness;Biology;Blood flow;Blood gas;Blood Pressure;Blood Vessels;Breeding;Calorimetry;Cardiac;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Centers of Research Excellence;Charge;Chemistry;Clinical Chemistry;Collaborations;Complement;cost;Death Rate;Development;disease model;Equipment;Exercise;exercise regimen;experimental study;Faculty;Feedback;Frequencies;Funding;Funding Agency;Future;Future Teacher;Generations;Genotype;Goals;Grant;Growth;Heart;heart function;Histologic;Histology;Human Resources;Immunohistochemistry;Implant;implantation;improved;in vivo Model;Income;Infrastructure;Institution;instrument;Intervention;laboratory experience;Lipids;Louisiana;Measurement;Measures;member;Mentors;Metabolic;Modality;Modeling;Modification;Mus;non-invasive imaging;Operative Surgical Procedures;Organ;Oxidation-Reduction;Pathologic;Pathology;Pathway interactions;Phase;Phenotype;Pilot Projects;Positioning Attribute;Post-Translational Protein Processing;Postdoctoral Fellow;Preparation;pressure;Price;programs;Protein Structure Initiative;Rattus;Regulation;Research;Research Personnel;Rodent;Rodent Model;Role;Running;Schools;Science;Services;Signal Transduction;skills;Source;Stains;Study models;Surgical Models;Surveys;System;Techniques;Technology;Telemetry;Temperature;Testing;Time;tissue processing;Tissues;Training;treadmill;ultrasound;United States;United States National Institutes of Health;VO2max;Wages

PROJECT_TITLE: Animal Models and Histology Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease

PI_NAMEs: ORR, ANTHONY WAYNE (contact)

PROJECT_TERMS: Biology;Blood Vessels;Capillary Electrophoresis;Cardiovascular Diseases;Cardiovascular Models;Cardiovascular system;Cause of Death;Cell Culture Techniques;Cell Hypoxia;cell injury;Cell Line;Cell model;Cell Physiology;Cells;Centers of Research Excellence;Communities;Core Facility;Data Analyses;Data Collection;Dedications;Detection;detection method;detector;Development;Ensure;Equipment;Experimental Designs;Faculty;faculty research;Funding;Generations;Goals;High Pressure Liquid Chromatography;Hydrogen Sulfide;Hypoxia;improved;Incidence;Individual;Infrastructure;Institution;Louisiana;mass spectrometer;Mass Spectrum Analysis;Measurement;Measures;Messenger RNA;metabolomics;Methods;Modeling;Modernization;Molecular;Molecular Biology;next generation sequencing;novel;operation;Oxidation-Reduction;Pathogenesis;Pathology;Phase;Post-Translational Protein Processing;Preparation;Production;Program Development;programs;Protein Analysis;protein function;Proteomics;Reactive Nitrogen Species;Reactive Oxygen Species;Regulation;Research;Research Personnel;Resources;Sampling;Services;Signal Transduction;Sulfur;Techniques;Technology;Tissues;Training;Training Programs;Transfection;Work

PROJECT_TITLE: Redox Molecular Signaling Core


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PHR: PROJECT NARRATIVE Despite advances in prevention and treatment of cardiovascular disease, it remains the leading cause of death in the US. In many cases the underlying cause is atherosclerosis of cardiac and cerebral arteries. We will test the ability of insulin-like growth factor-1 and a novel senolytic drug, ABT263, to prevent progression and worsening of atherosclerosis in a large animal model, and also use mouse models to understand underlying mechanisms and develop new therapies for cardiovascular disease.

PI_NAMEs: DELAFONTAINE, PATRICE  (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Aging;Animal Model;Antibodies;Aorta;Aortic Diseases;Apolipoprotein E;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Biology;Cardiovascular Diseases;cardiovascular disorder therapy;Cause of Death;Cell Aging;Cell Senescence Induction;cell type;Cells;cellular longevity;cerebral artery;Chromosome Mapping;Chronic Disease;Clinical Trials;Conditioned Culture Media;Coronary;Coronary artery;Coronary heart disease;coronary plaque;Data;Deposition;deprivation;Development;Diabetes Mellitus;Disease;Endothelial Cells;Event;Excision;extend lifespan;Familial Hypercholesterolemia;Family suidae;gain of function;Gene Expression;Genes;Genetic;Goals;Growth;Histology;Human;human disease;Hypertension;improved;In Vitro;in vitro Model;inhibitor;innovation;insight;Insulin;insulin-like growth factor binding protein-related protein 1;Insulin-Like Growth Factor I;Insulin-Like Growth-Factor-Binding Proteins;Insulin-Like-Growth Factor I Receptor;Invertebrates;Ischemia;Laboratories;laser capture microdissection;Lipids;Lipopolysaccharides;Longevity;loss of function;Macrophage;Manuscripts;member;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;novel;novel drug class;novel therapeutics;optimal treatments;Patients;Pharmaceutical Preparations;Play;Population;prevent;Prevention;Printing;Receptor Signaling;Resistance;revascularization;Risk;Risk Factors;Rodent;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Signal Transduction;single-cell RNA sequencing;Smoking;Smooth Muscle Myocytes;subcutaneous;Technology;Testing;Thinness;Tissue Sample;transcriptomics;Vascular Smooth Muscle;virtual

PROJECT_TITLE: Insulin-Like Growth Factor-1 and Atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Rare Diseases

PHR: PROJECT NARRATIVE Abdominal aortic aneurysm (AAA) is a life-threatening condition in adults with high mortality rate (80%) if rupture occurs but lacking pharmacological treatment. Vascular smooth muscle cell (VSMC) loss is a characteristic feature of AAA. The proposed research will determine the mechanisms by which VSMC ferroptosis contributes to AAA pathogenesis and lead to new therapeutic strategies for treating AAA.

PI_NAMEs: GUO, YANHONG  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: abdominal aorta;Abdominal Aortic Aneurysm;Address;adenoviral mediated;Adult;Alleles;Aneurysm;Angiotensin II;Animal Model;Aorta;Aortic Aneurysm;Apoptosis;Arteries;Attenuated;Blood Vessels;Cell Death;Cell Death Induction;Characteristics;cigarette smoke;Clinical Medicine;Contractile Proteins;Coupled;Cytoprotection;Data;Data Set;Databases;Death Rate;Development;Diameter;Disease;Dissection;Elastases;Embryo;Enzymes;epidemiology study;Extracellular Matrix Degradation;gain of function;gender difference;Gene Delivery;Gene Expression;Genes;Genetic;Germ Lines;glutathione peroxidase;Growth;high risk;Human;Human Genetics;hypercholesterolemia;Hyperlipidemia;In Vitro;in vivo;Incidence;Inflammatory Response;Inhibition of Apoptosis;inhibitor;Iron;Ischemia;knock-down;Knock-in Mouse;Knock-out;Knockout Mice;Lesion;Life;Lipid Peroxidation;Lipid Peroxides;long chain fatty acid;loss of function;LoxP-flanked allele;Malignant Neoplasms;Membrane Lipids;Modeling;Molecular;mortality;mouse model;Mus;Neurodegenerative Disorders;new therapeutic target;Nicotine;Nicotinic Acids;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;overexpression;Oxidative Stress;Palmitic Acids;Pathogenesis;Pathologic;Pathway interactions;Patients;Pentoxifylline;Pharmaceutical Preparations;Pharmacological Treatment;Phenotype;Play;prevent;protective effect;protein expression;Reduced Glutathione;Regulation;repaired;Reperfusion Therapy;Research;Resistance;response;Risk;Risk Factors;Role;Rupture;Ruptured Abdominal Aortic Aneurysm;Ruptured Aneurysm;single-cell RNA sequencing;Smoking;Smooth Muscle Myocytes;Solid;Stimulus;Structure;Testing;Thoracic aorta;tissue injury;Transgenic Mice;vascular inflammation;Vascular Smooth Muscle

PROJECT_TITLE: Vascular smooth muscle cell ferroptosis and abdominal aortic aneurysm


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Solution NMR, molecular simulations, proteomics, and biochemical assays, will explore a novel allosteric network in macrophage migration inhibitory factor (MIF) that regulates non-overlapping biological functions tied to inflammatory disease. The project will leverage the intrinsic plasticity of the MIF structure, exploring the allosteric effects of disease-linked mutations and oxidative solution on its signaling mechanism.

PI_NAMEs: LISI, GEORGE  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Active Sites;Affect;Affinity;Allosteric Site;Amino Acids;Animal Model;Asthma;Binding;Binding Sites;Biochemical;Biochemical Pathway;Biochemical Reaction;Biochemistry;Biological;Biological Assay;Biological Process;Biology;biophysical properties;Biophysics;cancer therapy;Catalysis;Cell surface;chemical property;Chemicals;chemokine receptor;Child;Chronic Childhood Arthritis;Communication;Coupling;cytokine;Data;design;Disease;driving force;Environment;Enzymatic Biochemistry;Enzymes;Equilibrium;Event;flexibility;Functional disorder;Glucocorticoids;Heterozygote;Human;human disease;Hydrogen Bonding;Immunosuppression;in silico;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory milieu;inhibitor;insight;Ligand Binding;Link;Maps;Measurement;Mediating;Migration Inhibitory Factor;Modification;Molecular;Molecular Bank;Molecular Conformation;molecular dynamics;Motion;Mutagenesis;mutant;Mutation;NMR Spectroscopy;novel;Nuclear Magnetic Resonance;Outcome;Oxidation-Reduction;Pathway Analysis;Pathway interactions;Peripheral;Property;Protein Dynamics;protein protein interaction;Protein Region;Proteins;Proteomics;Publications;receptor;Receptor Activation;Relaxation;Reporting;Resolution;Respiratory distress;response;Roentgen Rays;Role;Sampling;Scheme;Signal Pathway;Signal Transduction;simulation;Site;small molecule;Structure;Therapeutic;transmission process;Variant;Visualization;Work

PROJECT_TITLE: Unraveling the Allosteric Mechanism of Macrophage Migration Inhibitory Factor with Molecular Resolution

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breast Cancer;Breastfeeding, Lactation and Breast Milk;Cancer;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The plasma membrane calcium ATPase 2 (PMCA2) is a calcium pump found on the apical membrane of mammary epithelial cells that transports 60%-70% of milk calcium from within these cells into the alveolar lumen. We have found that PMCA2 expression is rapidly downregulated by milk stasis after weaning and that it is re-expressed in ErbB2/HER2-positive breast cancers. This renewal application seeks to continue our studies of PMCA2 during mammary gland involution and in breast cancer by: 1) examining how the decline of PMCA2 and resulting increase of intracellular calcium triggers new lysosome formation, STAT3 activation and cell death during early involution; and 2) examining how interactions between PMCA2, Erbin and NHERF1 form as a result of disturbed cell polarity to promote ErbB2 signaling, malignant transformation and resistance to trastuzumab.

PI_NAMEs: WYSOLMERSKI, JOHN J (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: 3-Dimensional;Acceleration;Alveolar;Apical;apical membrane;Applications Grants;basolateral membrane;Biochemical;Biogenesis;Breast Cancer Cell;Breast Epithelial Cells;Ca(2+)-Transporting ATPase;Calcineurin;Calcium;cancer cell;Cell Death;Cell membrane;Cell Polarity;Cell Survival;Cells;Complex;Couples;Cytoplasm;Data;Databases;Development;Drug Targeting;ERBB2 gene;experimental study;ezrin;Grant;Heat-Shock Proteins 90;Human;In Vitro;in vivo;in vivo calcium imaging;insight;knock-down;Knockout Mice;Knowledge;Lactation;Lesion;Lysosomes;Malignant - descriptor;Malignant Breast Neoplasm;mammary;Mammary gland;Mediating;Membrane;Milk;mortality;Mouse Mammary Tumor Virus;Multiprotein Complexes;Mus;Noninfiltrating Intraductal Carcinoma;novel;overexpression;Phosphorylation;PMCA1 protein;refractory cancer;Regulation;Resistance;response;scaffold;Scaffolding Protein;Signal Transduction;sodium-hydrogen exchanger regulatory factor;STAT3 gene;Testing;Therapeutic;Trastuzumab;tumor;Up-Regulation;Weaning

PROJECT_TITLE: PMCA2 regulates mammary gland involution and breast cancer

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Organ Transplantation;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because defining the ideal timing for neural tissue transplantation and identifying relevant factors associated with the host cortical microenvironment are important for optimizing strategies for rebuilding brain circuitry and restoring function after traumatic brain injury. Thus, the proposed research is relevant to the mission of the National Institutes of Neurological Disorders and Stroke in that it develops new knowledge that helps reduce the burden of neurological disease.

PI_NAMEs: CHEN, HAN-CHIAO ISAAC (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Acute;Acute Brain Injuries;Affect;Anatomy;Animals;Architecture;aspirate;Brain;brain circuitry;brain repair;Cell Line;cell replacement therapy;Cell Reprogramming;Cells;Cerebral cortex;Chronic;Chronic Phase;Cicatrix;Clinical;Cognitive deficits;cohort;controlled cortical impact;Data;Development;disability;efficacy evaluation;Excision;extracellular;Fluorescent Protein Tracings;Fostering;functional outcomes;functional restoration;Future;Gliosis;Goals;Green Fluorescent Proteins;Health;Histologic;Histology;Human;human induced pluripotent stem cells;improved;improved outcome;In Vitro;in vivo;injured;Injury;innovation;Knowledge;Maintenance;Mission;National Institute of Neurological Disorders and Stroke;Nature;Nervous System Disorder;neural;Neurologic Deficit;Neurons;novel strategies;optogenetics;organoid transplantation;Organoids;Outcome;Outcome Measure;patient - derived stem cells;personalized medicine;Phase;Photic Stimulation;post-transplant;Process;Public Health;Rabies virus;Rattus;Recovery;repair strategy;repaired;Research;response;Sensory;Severities;Stroke;Structure;Synapses;System;Techniques;Testing;Therapeutic;Thinness;tissue repair;Tissue Transplantation;Tissues;translational approach;Translations;Transplantation;Traumatic Brain Injury;Visual;Visual Cortex;visual stimulus

PROJECT_TITLE: Chronic Versus Acute Transplantation of Neural Tissues for TBI-Induced Cortical Injuries

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease

PI_NAMEs: KOLLURU, GOPI K (contact)

PROJECT_TERMS: Acceleration;Age;age effect;age related;age related biomarkers;aged;Aging;Alzheimer's Disease;Aorta;ataxia telangiectasia mutated protein;Atherosclerosis;ATR gene;Attenuated;Autophagocytosis;Award;Biological Availability;Biology;Blood Vessels;Cardiovascular Diseases;cardiovascular risk factor;Cell Physiology;Cell Separation;cofactor;Collaborations;Cystathionine;Cysteine Desulfhydrase;cytokine;Data;Defect;Disease;DNA Damage;DNA Repair;endoplasmic reticulum stress;Endothelial Cells;endothelial dysfunction;Endothelium;extend lifespan;Female;Free Radicals;Genetic;Goals;Growth;Harvest;Human;Hydrogen Sulfide;Impairment;Inflammatory;inhibition of autophagy;Ischemia;Length;life span;Lyase;macromolecule;male;Manuscripts;Measures;Mediating;Mediator;Molecular;Mus;novel;old mice;Organelles;Organism;Oxidation-Reduction;Oxidative Stress;Pathology;Peer Review;pharmacologic;Phosphotransferases;polysulfide;pro-aging;Process;Protein Kinase;Proteins;Regulation;Research;response;Role;Signal Transduction;Sirtuins;Stress;Stroke;sulfhydration;Sulfides;Telomerase;Telomere Shortening;Therapeutic;therapeutic target;Time;Vascular Diseases;Vascular remodeling;Vasodilation

PROJECT_TITLE: Cystathionine Gamma Lyase (CSE) and Hydrogen Sulfide Regulation of Vascular Aging


NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

PHR: Project Narrative Stem cells are important for public health because they are essential for the growth, maintenance, and repair of tissues and lie at the heart of many cancers. Additionally, many regenerative medicine strategies propose the utilization of stem cells to replace missing or undesirable cells. Planarians present a new and powerful system to identify molecular mechanisms that regulate stem cells for regeneration.

PI_NAMEs: REDDIEN, PETER  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Address;Adult;adult stem cell;Animals;Architecture;Atlases;base;blastema;blind;Body part;Case Study;Cell Differentiation process;cell fate specification;cell type;Cells;Cues;Dreams;Evolution;Future;Growth;Heart;Injury;Investigation;Maintenance;Malignant Neoplasms;Molecular;Names;Natural regeneration;Organism;Pattern;Planarians;Platyhelminths;pluripotency;Process;Production;progenitor;Proliferating;Public Health;regeneration model;regenerative;Regenerative Medicine;repaired;Research;response;restoration;self organization;Specific qualifier value;Specificity;stem cell fate;stem cell self renewal;stem cells;Stochastic Processes;System;therapeutic development;tissue regeneration;tissue repair;Tissues;transcriptome;transcriptomics;Work;wound;wound healing

PROJECT_TITLE: Stem cell and regeneration regulatory mechanisms in planarians


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: DENTISTRY

PHR: Project Narrative For dentin repair or regeneration, it is important to have the timely appearance of blood vessels. Therefore, tissue-engineering strategies to regenerate the dentin-pulp complex require establishment of vasculature to deliver oxygen, nutrients, hormones, immune cells, minerals and also help in clearing cellular debris and metabolic waste products during the inflammatory and regenerative phases of healing. The goal of this project is demonstrate that dentin matrix protein 1 is involved in vasculogenesis. Understanding the function of DMP1 in the phenotypic transformation of dental pulp stem cells to endothelial cells will help in regenerating vascularized tissues such as the dental pulp.

PI_NAMEs: GEORGE, ANNE  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;Adsorption;adult stem cell;angiogenesis;Angiogenic Factor;Angiogenic Proteins;Appearance;arm;ATF6 gene;Binding;Biological Assay;Blood Vessels;bone;bone fracture repair;Bone Matrix;cadherin 5;Calcium;Cell Maintenance;Cell Nucleus;Cell Physiology;Cell Proliferation;Cell Surface Receptors;Cell Survival;Cells;Cellular Stress;Collagen;Competence;Complex;Complex Mixtures;Confocal Microscopy;coping;Data;Dental Pulp;Dentin;dentin matrix protein 1;Disease;Endoplasmic Reticulum;endoplasmic reticulum stress;Endothelial Cells;Endothelium;engineered exosomes;Event;exosome;Exposure to;extracellular;Extracellular Matrix;FGF2 gene;Fibronectins;Genetic Materials;genetic regulatory protein;Genetic Transcription;Genomics;Glucose;Goals;Growth;GRP78 gene;Harvest;healing;Histology;Hormones;Hydroxyapatites;Immune;Implant;in vivo;in vivo evaluation;Inflammatory;Integral Membrane Protein;Knockout Mice;Matrix Metalloproteinases;Mediating;Metabolic;migration;mineralization;Minerals;Modeling;mouse model;Mus;N-terminal;Natural regeneration;neovascularization;novel;Nuclear;Nutrient;Odontoblasts;Osteoblasts;Outcome;overexpression;Oxygen;paracrine;Paracrine Communication;PECAM1 gene;Phase;Phenotype;Platelet-Derived Growth Factor;precursor cell;progenitor;promoter;Protein Array;Proteins;Proteomics;regeneration model;regenerative;Regenerative Medicine;Regulation;repaired;response;response biomarker;Role;scaffold;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;Slice;stem cells;subcutaneous;Testing;Therapeutic;Therapeutic Effect;therapy development;Three-Dimensional Imaging;Time;Tissue Engineering;tissue regeneration;tissue repair;Tissues;Tooth structure;transcription factor;Transcriptional Activation;Transcriptional Regulation;transcriptome sequencing;Transgenic Mice;Validation;Vascular Endothelial Growth Factors;Vascular System;Vascularization;vasculogenesis;Vasculogenic;VEGFA gene;VWF gene;Waste Products;Western Blotting

PROJECT_TITLE: Role of DMP1 Mediated Paracrine Signaling in Vasculogenesis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative/Public Health Relevance Statement Alzheimer's disease (AD) is one of the leading causes of death in the U.S. and affects approximately 20% of adults in their sixties and 50% over 85 years, creating a heavy burden on the society as well as patients and their families. Given the long prodromal stage of the disease, development of non-invasive and cost-effective methods to detect AD pathologies during the early stage of AD will be crucial for prevention and intervention of AD as well as recruitment of study participants for drug development trials. Completion of the project will markedly improve the understanding of the mechanisms linking AD pathologies to cognitive impairment in the earliest stage of the disease, which will help early detection and development of effective prevention and intervention for individuals at high-risk for AD.

PI_NAMEs: OH, HWAMEE  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta deposition;Adult;Affect;Age;age group;aging brain;Alzheimer disease detection;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Area;area striata;Attention;Awareness;Behavior assessment;Behavioral;behavioral phenotyping;Binding;Biological Markers;Brain;Brain region;Cause of Death;Clinical;Clinical Research;Cognition;Cognitive;cognitive change;cognitive function;cognitive neuroscience;cognitive task;cognitive testing;cohort;Computers;cost effective;Deposition;Development;Disease;drug development;Early Diagnosis;Early treatment;Elderly;Family;Functional Magnetic Resonance Imaging;Goals;high risk;Hippocampus;Human;Impaired cognition;improved;in vivo;Individual;innovation;Intervention;Link;Measures;medial temporal lobe;Memory;Memory impairment;Methods;Monitor;Motor Cortex;National Institute on Aging;Nerve Degeneration;neural;Neurofibrillary Tangles;neuroimaging;neuroimaging marker;Neuropsychological Tests;Neuropsychology;Neurosciences Research;novel;older adult;Parietal Lobe;Participant;Pathologic;Pathology;Patients;Pattern;Perception;Performance;Positron-Emission Tomography;pre-clinical;Predisposition;Prefrontal Cortex;Prevention;Procedures;Process;public health relevance;recruit;Registries;Research;screening;Senile Plaques;Sensitivity and Specificity;Sensory;Societies;Standardization;Structure;Symptoms;System;tau Proteins;Taxes;Testing;Therapeutic Intervention;Time;verbal;visual information;visual stimulus;young adult

PROJECT_TITLE: Developing novel cognitive and neuroimaging markers of early Alzheimers disease pathologies

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: Project Narrative The mitochondrial fatty acid synthesis (mtFAS) pathway is a major rheostat of mitochondrial function, but the pathway is poorly defined in mammals and almost nothing is known about its regulation. Our preliminary data in yeast and cultured cells support a model in which mtFAS activity responds to changes in nutrient availability in the mitochondria, but many questions remain, including which fuels drive mtFAS, and how the pathway acts to direct metabolism in tissues with disparate mitochondrial functions. The experiments outlined in this proposal will mechanistically characterize the basic biology of mtFAS pathway function and regulation in mammalian systems.

PI_NAMEs: NOWINSKI, SARA MARIE (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acetyl Coenzyme A;Area;Bioenergetics;Biogenesis;Biology;Cell Differentiation process;cell type;Cells;Citric Acid Cycle;Cultured Cells;Cytoplasm;Data;detection of nutrient;Disease;Disparate;Electron Transport;Environment;experience;experimental study;Fatty Acids;Fatty-acid synthase;Genes;Goals;Iron;Laboratories;Lipids;macromolecule;Mammals;Membrane;Metabolic;Metabolism;Mitochondria;mitochondrial metabolism;Modeling;Monitor;Nutrient availability;Nutritional;Pathway interactions;Play;Positioning Attribute;Regulation;Research;response;Role;Signal Transduction;Source;Specificity;success;Sulfur;Supporting Cell;System;Tissues;uptake;Writing;Yeasts

PROJECT_TITLE: Regulation of mitochondrial fatty acid synthesis in the control of mitochondrial metabolism.

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: The neurology community has seen extraordinary successes and tremendous breakthroughs in the treatment of neurological disorders. Translating these advances into improved clinical care for patients requires a cadre of specialty-trained clinician neuroscientists who are to be responsive to the increasing pace of scientific discoveries, as well as to the emerging suite of approaches and techniques. This program will train the next generation of leaders in the experimental therapeutics of neurological disease, in order to accelerate therapeutic development and improve access to emerging breakthroughs for all patients and families who may benefit.

PI_NAMEs: GRIGGS, ROBERT C (contact);HOLLOWAY, ROBERT G.

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Investigational Therapies;Nervous System Disorder

PROJECT_TITLE: Experimental Therapeutics in Neurological Disease


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Research Narrative We are trying to learn the fundamental principles which govern how different bacteria in a population respond to changes in their environment, such as treatment with an antibiotic. Rather than a population in which all bacteria are prepared for any environmental change, we hypothesize that each individual in the population is prepared for certain environments - and that their preparation changes randomly over time depending on the expression of their genes. Combining cutting-edge experimental and computer modeling techniques, our goal is to demonstrate that this phenomenon exists within individual bacteria, and show how it impacts the population as a whole.

PI_NAMEs: COVERT, MARKUS W (contact)

PROJECT_TITLE: Multi-scale, model-driven exploration of sub-generational gene expression in bacteria: individual consequences, population benefits

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Down Syndrome;Eye Disease and Disorders of Vision;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Public Health Relevance: Over 400,000 individuals in the United States have Down syndrome (DS) and are living with the significant challenges of cognitive and visual deficits, both of which pose serious threats to the maximum potential of these individuals. Improving visual health remains the primary mission of the National Eye Institute, and becomes particularly critical when the affected individuals cannot advocate for themselves, such as is the case for persons with DS. This proposal aims to test new objective spectacle prescribing strategies to provide improvements in visual quality for individuals with DS which is ultimately anticipated to improve their performance of visually demanding activities of daily living and foster greater independence.

PI_NAMEs: ANDERSON, HEATHER ANNE (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Advocate;Affect;Age;Amblyopia;Back;Child;Childhood;Clinical;clinical examination;Cognitive;cohort;Compensation;Cornea;Corneal Topography;Crossover Design;Development;disabled;Down's Syndrome;Early Intervention;Education;Enrollment;Evaluation;experience;expiration;Exposure to;Eye;Eyeglasses;follow-up;Fostering;Funding;Goals;Health;Hybrids;Hyperopia;Image;Impaired cognition;improved;Individual;innovation;Lead;Measurement;Measures;Methodology;Methods;Mission;monocular;National Eye Institute;novel therapeutic intervention;Optics;Outcome;patient population;Patients;Persons;Population;prevent;primary outcome;Printing;Process;Protocols documentation;public health relevance;Randomized;rate of change;Reading;Refractive Errors;Research;retinal imaging;simulation;stem;Techniques;Testing;tool;treatment arm;treatment trial;United States;Update;Vision;Visit;Visual;Visual Acuity;visual performance;Work

PROJECT_TITLE: Identification of optimum spectacle prescriptions for patients with Down syndrome


NIH_SPENDING_CATS: Cardiovascular;Hematology

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Extracorporeal circulation through a membrane oxygenator (ECMO) is used for severe heart and lung failure support worldwide, despite a high incidence of bleeding caused by systemic anticoagulation. Without adequate systemic anticoagulation components of the ECMO circuit are prone to clotting putting at risk patients. This research will refine our nitric oxide (NO) based nonthrombogenic surface which can eliminate systemic anticoagulation and set the stage for commercial development.

PI_NAMEs: ROJAS-PENA, ALVARO  (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: Accounting;Adhesions;Affect;Animal Model;Anticoagulants;Anticoagulation;Argatroban;Attention;Binding;Blood flow;Blood Platelets;Cardiopulmonary Bypass;Chemistry;Clinical Trials;Coagulation Process;commercial application;compare effectiveness;comparison control;Critical Care;design;Development;Devices;Dose;Effectiveness;effectiveness evaluation;Endothelium;Experimental Designs;experimental study;Extracorporeal Circulation;Fibrin;Functional disorder;Gases;Generations;Goals;Grant;Heart failure;Hemodialysis;Hemofiltration;Hemorrhage;Heparin;Hour;hydrophilicity;Incidence;inhibitor;Laboratories;Learning;Life;lung failure;Medicine;Membrane Oxygenators;Morbidity - disease rate;mortality;Nitric Oxide;Oxygenators;Patients;Platelet Activation;platelet function;pre-clinical;prevent;prototype;Research;Research Project Grants;Risk;SARS-CoV-2 infection;Series;Sheep;Source;Standardization;Surface;surface coating;System;Technology;Testing;Thrombin;thrombogenesis;Thrombosis;Time;United States National Institutes of Health

PROJECT_TITLE: ECMO without Anticoagulation

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project narrative  Disruption of genomic regulation is accompanied by striking functional changes across cell types and species. However, how mobile genetic elements are regulated throughout life, across biological sexes, and how they influence physiology in response to external or internal cues, remains largely unknown. By leveraging big data and state-of-the-art experimental approaches on vertebrate models including mouse and the emerging African turquoise killifish, the proposed research program will advance our understanding of mobile genetic element control in healthy somatic cells, and shed light on how these elements can influence vertebrate health and disease. 1

PI_NAMEs: BENAYOUN, BERENICE ANATH (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Adult;African;age related;Aging;Animal Model;Antibodies;Big Data;biological sex;Biology;cell type;Cells;cost effectiveness;Cues;Data;Development;Disease;DNA Transposable Elements;Elements;Family;Female;functional decline;functional genomics;Generations;Genetic;Genome;Genomics;Goals;Gonadal Hormones;Health;Homeostasis;Jumping Genes;Junk DNA;Killifishes;Laboratory mice;Life;life span;Link;Machine Learning;male;Malignant Neoplasms;Mobile Genetic Elements;model organism;Modeling;Mus;Nature;Nerve Degeneration;Organism;Parasites;Pattern;Physiology;prevent;programs;Regulation;Research;response;sex;Sex Chromosomes;sexual dimorphism;Somatic Cell;Time;Tissues;Validation

PROJECT_TITLE: Understanding the regulation and impact of transposable elements in Vertebrate health and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Cells employ multiple strategies, including transcriptional and posttranscriptional regulation events, to ensure that the correct protein is made at the right time and place. Failure to do so could result in drastic consequences such as cancer and cell death. This proposal addresses the mechanisms by which protein synthesis is regulated to maintain control over gene expression, which in turn could be used to develop therapeutics aimed at dealing with defects in the translation apparatus.

PI_NAMEs: ZAHER, HANI  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Affect;Agreement;Alkylation;Binding;Biochemistry;biological adaptation to stress;Cell Death;Cells;Chemicals;Complex;Cryoelectron Microscopy;Cues;Data;Defect;DNA Damage;DNA Repair;DNA Repair Pathway;Eukaryota;Event;experimental study;Failure;Frequencies;Funding;Gene Expression;Genetic Transcription;Homeostasis;insight;Kinetics;Link;Malignant Neoplasms;Mammals;Messenger RNA;Molecular;Molecular Conformation;Mutation;Nuclear;Nucleic Acids;Organism;Output;oxidation;Pathway interactions;Peptide Initiation Factors;Phosphorylation;Phosphotransferases;Play;Post-Transcriptional Regulation;Post-Translational Protein Processing;Process;Production;programs;Proliferating;Protein Biosynthesis;Protein Kinase;Proteins;Quality Control;reconstitution;Recovery;recruit;Regulation;Repression;Resources;response;Ribosomal Proteins;Ribosomes;RNA;Role;Saccharomyces cerevisiae;sensor;Sentinel;Signal Transduction;Site;Stress;Structure;Study models;TATA-Box Binding Protein;Testing;Therapeutic;Thermodynamics;Time;Transcription Coactivator;transcription factor;transcriptional reprogramming;Translational Derepression;Translations;ubiquitin-protein ligase;Ubiquitination;yeast genetics;Yeasts

PROJECT_TITLE: Ribosome stalling and activation of stress responses

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Public Health Relevance Statement Mob4 is a gene recently linked to Alzheimer’s Disease, whose function is yet to be determined. Using Drosophila genetics, biochemistry and imaging, we will determine the molecular function of Mob4 and its interacting proteins in neurons and in long-term memory formation. A mechanistic understanding of Mob4 function will provide possible therapeutic treatment strategies for Alzheimer’s disease.

PI_NAMEs: NEISCH, AMANDA LOUISE (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease patient;Axonal Transport;Behavioral;Binding;Binding Proteins;Biochemistry;Biological Assay;Biological Models;Cell Physiology;Complex;Data;Defect;Dementia;Development;Disease;Disease Progression;Drosophila genus;Endosomes;Functional disorder;Genes;Genetic;Goals;Hippocampus;Image;Impairment;insight;Late Onset Alzheimer Disease;Link;long term memory;Mediating;Memory;Microtubule-Associated Proteins;Mitochondria;Molecular;Motor;Multiprotein Complexes;Nervous System;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurons;Neuropeptides;novel;novel therapeutic intervention;Organelles;Pathogenesis;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphoserine;Phosphotransferases;prevent;Process;Protein Dephosphorylation;Protein Family;protein function;Protein Phosphatase 2A Regulatory Subunit PR53;protein transport;Proteins;public health relevance;recruit;Regulation;Research;Research Proposals;Role;scaffold;Scaffolding Protein;Testing;Therapeutic;Threonine;treatment strategy

PROJECT_TITLE: Mob4 activity and dysfunction in Alzheimer's Disease

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Stem cell-based treatments offer unprecedented hope to treat human neurological disorders. Training of junior scientists having expertise in stem cell biology and neuroscience, together with a comprehensive understanding of industry, regulatory clinical and statistical knowledge, is essential to realization of this vision. We have implemented these goals within our NIH Training Program in Stem Cell Translational Medicine for Neurological Disorders, now in its 9th year, to train predoctoral students in integrated and translational approaches to stem cell biology, neuroscience and human neurological disease and propose to renew and further strengthen this successful training program.

PI_NAMEs: DONOVAN, PETER JOHN;THOMPSON, LESLIE MICHELS (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Nervous System Disorder;stem cells;Training Programs;translational medicine


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Intersectional stigma remains a persistent barrier to ending the HIV epidemic in the US and more broadly, the HIV pandemic and is a stated research priority of the NIH including through publications and notice of special interest. While we know that intersectional stigmas drive disparities in health, but there remains limited understanding of optimal measurement to assess effects on health outcomes and the impact of interventions. This proposed study aims to address these gaps by optimizing measurement of intersectional stigma among sexual and gender minorities, mechanisms driving health inequities, and informing interventions to mitigate disparities.

PI_NAMEs: BARAL, STEFAN DAVID (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Address;Affect;AIDS prevention;American;Automobile Driving;Behavior Therapy;Caring;cis-male;cognitive interview;Communities;Complement;Comprehension;Consensus;Data;Disparity;disparity reduction;Epidemic;Equation;experience;Factor Analysis;Feeling suicidal;follow-up;Funding;Gender;gender affirming care;Gender Identity;geographic difference;Geography;Goals;Health;health disparity;health inequalities;Heterogeneity;High Prevalence;HIV;Individual;interest;Internet;Intervention;Interview;Judgment;Location;Measurement;Measures;Mediation;Mediator;men;men who have sex with men;Mental Depression;Mental Health;Methods;Modeling;multilevel analysis;National Institute of Mental Health;Outcome;pandemic disease;Participant;participant enrollment;physical conditioning;Poverty;pre-exposure prophylaxis;prevention service;Primary Care;Property;Psychological Stress;Psychometrics;Publications;Race;Reporting;Research;Research Design;Research Priority;resilience;response;Retrieval;Role;Sampling;Sex Behavior;Sex Orientation;Sexual and Gender Minorities;Sexual Health;sexually active;Sexually Transmitted Diseases;Shapes;social capital;social determinants;social stigma;Social support;Socioeconomic Status;Structure;substance use;Surveys;Testing;transgender women;treatment services;trend;United States National Institutes of Health;Urbanicity;Variant;Work

PROJECT_TITLE: Characterizing intersecting sexual, gender, and race-based stigmas affecting communities of US transgender women and cisgender men who are sexually active with men

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: MADISON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative The use of the common marmoset (Callithrix jacchus) in biomedical research has increased by an unprecedented extent over the past five years, emerging as a critical biomedical model system in a variety of study disciplines. Increased demand for marmosets in scientific research studies has perhaps been most acute in neuroscience, where the need to study cognition, behavior, and mental illness in primate models has grown in part in part due to recognition of inherent limitations of rodent models in translational studies of human physiology and disease. The Southwest National Primate Research Center (SNPRC) and the Wisconsin National Primate Research Center (WNPRC) propose a major collaborative effort to dramatically increase the availability of healthy common marmosets for national neuroscience research projects.

PI_NAMEs: LEVINE, JON E (contact);ROGERS, JEFFREY A.;ROSS, CORINNA NICOLE

PROGRAM_OFFICER_NAME: LIU, CHRISTINA HUANG

PROJECT_TERMS: Acute;Animal Disease Models;Animal Experiments;Animals;Architecture;Behavior;Biological Models;Biomedical Research;Brain;Breeding;Callithrix;Callithrix jacchus jacchus;Caring;Characteristics;Cognition;Collaborations;collaborative approach;Communication;Communities;Data;Databases;Discipline;Disease;Embryo;Ensure;Fertility;gene therapy;gene-editing approach;genetic pedigree;Genetic Variation;genome editing;Genomics;Genotype;Growth;Health;high standard;Human;improved;Infant;innovation;Institution;Life Cycle Stages;life span;mature animal;Mental disorders;Modeling;Neurosciences;Neurosciences Research;nonhuman primate;Output;Physiology;postnatal;prenatal;Primates;Production;Recording of previous events;Records;Reproduction;reproductive;reproductive success;Research;Research Project Grants;research study;Resources;response;Rodent Model;Social Behavior;social communication;somatic cell gene editing;success;System;technique development;Techniques;translational study;United States National Institutes of Health;Wisconsin;young adult

PROJECT_TITLE: Collaborative Expansion of Marmoset Colonies for Neuroscience Research


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Contraception/Reproduction;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE Elucidating the biochemical and conformational changes that initiate cervical ripening will provide a critical step for early detection and treatment of preterm birth, which is the leading cause of infant morbidity and mortality. Raman spectroscopy is a non-invasive, label-free, and highly specific approach for probing tissue biochemistry, which can be implemented in vivo using a fiber optic probe. This proposal will develop multimodal in vivo Raman spectroscopy along with complementary ex vivo imaging techniques to gain in-depth, quantitative information regarding changes in extracellular matrix organization, lipid and water content, and vascularity in order to understand how these components are altered in mouse models of premature cervical remodeling and preterm birth.

PI_NAMEs: MAHADEVAN-JANSEN, ANITA  (contact);REESE, JOHN JEFFREY

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Actins;Affect;Alprostadil;Biochemical;Biochemical Markers;Biochemistry;Biological;Biological Assay;Biological Sciences;biomechanical test;Biomechanics;Biomedical Engineering;Blood;Blood Vessels;Carbocyanines;Cardiac;Cervical;cervical remodeling;Cervical Ripening;Cervix Incompetence;Cervix Uteri;Clinical;Collagen;Complex;Custom;data fusion;decorin;design;Detection;Development;Dyes;Early Diagnosis;Early treatment;Elasticity;Elastin;Etiology;ex vivo imaging;Extracellular Matrix;Extracellular Matrix Proteins;Fiber Optics;Fingerprint;Freeze Drying;Goals;Health;Heme;Hormonal;Human;Hyaluronic Acid;Hydration status;Image;Imaging Techniques;Immunohistochemistry;Impairment;improved;in vivo;in vivo monitoring;in vivo optical imaging;infant morbidity;infant morbidity/mortality;Infection;innovation;insight;Interdisciplinary Study;Label;Length;Light;Lipids;Longitudinal Studies;Maps;Measures;Mechanics;Medical;Microscope;microscopic imaging;Microscopy;Mifepristone;Modeling;Molecular;Molecular Conformation;Monitor;morphometry;mouse model;Multi-modal optical imaging;multimodality;Mus;neonatal morbidity;Neonatal Mortality;novel;Optics;Outcome;Perfusion;Perinatal;Phase;Phenotype;physical science;Physiological;Physiology;Pregnancy;pregnant;premature;Premature Birth;Preparation;Process;Property;Proteins;Proteoglycan;prototype;Raman Spectrum Analysis;Reporting;Reproduction;Research;Research Project Grants;response;Structural Protein;Syndrome;System;Techniques;Technology;Term Birth;Testing;Time;Tissue imaging;tissue mapping;Tissues;United States;Uterus;Vascularization;Visualization;Water;Work

PROJECT_TITLE: Complementary ex vivo multimodal optical imaging and in vivo Raman spectroscopy to understand tissue dynamics

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


PHR: Project Narrative This program provides postdoctoral education, training, and experience in field-leading laboratory research on childhood cancers for pediatric oncology-hematology physician-scientists. It ensures that a pipeline of well- trained physician-scientists can continue the progress that has been made in the treatment of these life- threatening diseases affecting children.

PI_NAMEs: FRIEDMAN, ALAN D (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Lab Research Training in Pediatric Oncology-Hematology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Aminoacyl-tRNA synthetases (ARSs) are a family of enzymes that are essential for the production of cellular proteins. To date, genes encoding ARSs have been implicated in many human diseases; however, the process by which these genes cause specific diseases is still unknown. Here, we aim to define how ARS genes cause human disease toward developing effective therapeutics.

PI_NAMEs: ANTONELLIS, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Affect;Alleles;Amino Acids;Amino Acyl-tRNA Synthetases;Area;Biochemical;Biological Assay;Biological Models;Cell Survival;clinical phenotype;Data;Diagnosis;Disease;disease phenotype;Dominant-Negative Mutation;Enzymes;Family;gain of function;gene function;Genes;Health;Hereditary Disease;Human;human disease;improved;In Vitro;in vivo;insight;Ligation;loss of function;Mammalian Cell;Mass Spectrum Analysis;Messenger RNA;Molecular;molecular pathology;mouse model;Mus;Mutagenesis;Neuropathy;Onset of illness;Pathogenicity;patient population;Patients;Peripheral Nervous System Diseases;Phenotype;Population;Process;Production;protein expression;Proteins;ribosome profiling;Role;Testing;therapeutically effective;Tissues;Transfer RNA;Transfer RNA Aminoacylation;Translations;Variant;Yeasts

PROJECT_TITLE: Defining the Role of Aminoacyl-tRNA Synthetases in Human Health and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Human Genome;Methamphetamine;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Deaths attributed to concomitant opioid and stimulant polysubstance use are increasing at an alarming rate. There is a critical need to advance both the preclinical behavioral procedures and the brain molecular interrogations to identify and characterize how polysubstance use synergizes to drive this public health crisis. This application proposes preclinical research focused on fentanyl and methamphetamine drug-vs.-food choice procedures in rats combined with single nuclei RNA sequencing of distinct brain regions to uncover the root brain molecular mechanisms that emerge over the course of polysubstance use.

PI_NAMEs: BANKS, MATTHEW L;HAMILTON, PETER JAMES (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Area;Behavior;Behavioral;Behavioral Model;Biological Assay;Brain;brain cell;Brain region;brain reward regions;cell type;Cessation of life;Choice Behavior;Classification;Clinical;comorbidity;Consumption;Data;Data Set;Decision Making;Drug Addiction;drug reinforcement;Drug usage;drug use behavior;experience;Female;Fentanyl;fentanyl self-administration;fentanyl use;Food;Gene Expression Profile;Genetic Transcription;Goals;Human;improved;male;Medial;Methamphetamine;methamphetamine use;Modeling;Molecular;Neuroglia;non-drug;novel;Nucleus Accumbens;Opioid;opioid misuse;opioid use;Pathogenesis;Pharmaceutical Preparations;pharmacologic;Phase;polysubstance use;pre-clinical;pre-clinical research;Prefrontal Cortex;Procedures;Process;Public Health;Publishing;Rattus;Recording of previous events;Recovery;reinforcer;Research;Research Priority;response;Rewards;Risk;Saline;Self Administration;Severities;single nucleus RNA-sequencing;Stimulant;stimulant misuse;stimulant use disorder;substance use;synergism;Testing;Tissues;Transcript;transcriptome sequencing;Withdrawal;Work

PROJECT_TITLE: Cell type transcriptional mechanisms of polysubstance choice


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunotherapy;Lung;Lung Cancer;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality in the United States and worldwide, underscoring the critical need to identify new therapeutic targets for this disease. This project seeks to define the fundamental mechanisms by which the XRN1 exoribonuclease, an enzyme that functions to degrade cellular RNA, regulates the survival of NSCLC cells and the anti-tumor immune response to NSCLC tumors. The proposed research will determine whether targeting XRN1 may represent a unique and broadly applicable treatment strategy for patients with NSCLC.

PI_NAMEs: ZOU, TAO  (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;anti-PD-1;anti-PD-1/PD-L1;anti-tumor immune response;Basic Science;biological adaptation to stress;Biology;Biopsy;Cancer Biology;cancer cell;Cancer cell line;Cancer Etiology;cancer immunotherapy;Cancer Model;career development;Cell Death;Cell Survival;Cells;checkpoint inhibition;Clinical;clinical practice;cohort;Communities;Computational Biology;CRISPR/Cas technology;Cyclic AMP-Dependent Protein Kinases;cytokine;Cytoplasm;Dana-Farber Cancer Institute;Data;Development;Development Plans;Disease;DNA Sequence Alteration;Double-Stranded RNA;Ensure;Environment;Enzymes;Eukaryotic Initiation Factors;Exoribonucleases;experimental study;Flow Cytometry;Funding;Gene Expression;Gene Expression Profiling;gene induction;Genes;Genetic;genome-wide;Goals;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;immune RNA;Immunotherapy;Implant;improved;improved outcome;in vivo;innovation;insight;Interferon Type I;Laboratories;Laboratory Research;Link;loss of function;lung cancer cell;Malignant neoplasm of lung;Mediating;medical schools;member;Mentorship;Modeling;Molecular;molecular targeted therapies;mortality;Mus;mutant;Mutation;new therapeutic target;Non-Small-Cell Lung Carcinoma;Oncogenic;Oncologist;Pathway interactions;Patient Care;patient subsets;Patient-Focused Outcomes;Patients;PD-1 inhibitors;PD-1/PD-L1;PDL1 pathway;pharmacologic;Phosphorylation;Physicians;poly A specific exoribonuclease;Positioning Attribute;predictive marker;programmed cell death ligand 1;programs;protein kinase R;Proteins;recruit;Regimen;Research;research and development;Research Personnel;Research Proposals;Resistance;Resources;response biomarker;RNA;RNA Degradation;RNA metabolism;Scientist;sensor;Signal Induction;Signal Pathway;Signal Transduction;synergism;targeted treatment;Therapeutic;therapeutic target;Time;Training;Translational Research;translational study;treatment response;treatment strategy;tumor;tumor eradication;Tumor Immunity;tumor immunology;tumor microenvironment;United States

PROJECT_TITLE: Characterizing the XRN1 exoribonuclease as a therapeutic target in non-small cell lung cancer

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Primary Health Care;Recovery Support Services;Social Determinants of Health;Substance Misuse

ORG_CITY: COLLEGE PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative To end the HIV epidemic in the US and globally, behavioral interventions are needed for those at highest risk for HIV nonadherence and subsequent HIV transmission, including low-income, racial/ethnic minority individuals with active substance use (SU). Efforts to integrate HIV, SU, and primary care services in resource- limited settings globally must allocate resources efficiently. Implementing a peer-delivered, stepped care intervention for HIV medication adherence and SU may be a sustainable and effective way to improve HIV treatment outcomes and reduce SU in this population.

PI_NAMEs: MAGIDSON, JESSICA F (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Address;Adherence;Adoption;Affect;Aftercare;antiretroviral therapy;Attitude;Behavior Therapy;Behavioral;Biological Markers;Blood;Caring;Clinic;Clinical;Continuity of Patient Care;cost effective;cost estimate;Counseling;Data;design;Diabetes Mellitus;Dose;Dryness;economic impact;economic value;Effectiveness;effectiveness outcome;effectiveness testing;effectiveness trial;effectiveness-implementation randomized trial;effectiveness/implementation hybrid;effectiveness/implementation trial;electronic adherence monitoring;Epidemic;ethnic minority population;Evidence based intervention;Feedback;Health;Health Care Sector;high risk;high risk population;HIV;Home;Hybrids;Hypertension;implementation measures;implementation outcomes;implementation strategy;improved;Individual;Intervention;Interview;Life;low and middle-income countries;Low income;Measures;medication compliance;Mental Depression;Mental Health Services;Mentored Patient-Oriented Research Career Development Award;Methods;mindfulness;Modeling;motivational enhancement therapy;motivational intervention;National Institute of Drug Abuse;Outcome;Participant;Patient Participation;patient retention;Patient Self-Report;Patients;peer;peer recovery;Persons;phosphatidylethanol;Pilot Projects;Policy Maker;Population;preference;Primary Care;primary care services;primary care setting;primary outcome;Problem Solving;Provider;Qualitative Research;racial minority;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;reduced substance use;relapse prevention;Resource Allocation;Resource-limited setting;Resources;response;Services;Site;skills;South Africa;Spottings;standard of care;substance use;Substance Use Disorder;substance use treatment;success;Testing;therapy adherence;Time;Training;transmission process;Treatment outcome;treatment program;uptake;Urinalysis;Viral Load result;willingness to pay;Work

PROJECT_TITLE: Stepped Care, Peer-Delivered Intervention to Improve ART Adherence and SUD in Primary Care


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Dental, Oral, and Craniofacial Disease;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: PROJECT NARRATIVE Out of the 131,000,000 live births every year in the world, 25% of infants of single pregnancies and 50% of infants of multiple pregnancies have some degree of skull deformity at birth that, if not diagnosed early and treated effectively, can impact brain development, cognition, and motor function. This project will be the f irst systematic in-vivo study of joint healthy cranial and brain development—before and after birth—that will address our current limited knowledge of how the cranium and brain grow and co -develop; the normative models generated here will serve as clinical resources for matched comparisons in individual children with suspected disorders that involve abnormal cranial shapes. Additionally, precise in-vivo quantitative imaging methods for assessing joint cranial and brain shape in infants will be developed in this project and will serve as invaluable tools for physicians to better assess, diagnose, and plan treatment for infant cranial deformities in the future.

PI_NAMEs: LEPORE, NATASHA  (contact);LINGURARU, MARIUS GEORGE

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Affect;Age;aged;Ants;Arizona;automated segmentation;Birth;bone;Bone Development;Brain;brain abnormalities;brain morphology;brain shape;brain tissue;brain volume;Brodmann's area;Cephalic;Child;Childhood;Clinical;Clinical Management;Cognition;Colorado;cortex mapping;Craniosynostosis;cranium;Data;Data Set;data standards;Databases;Deformity;design;Development;developmental disease;Diagnosis;Diffusion;Disease;early childhood;Evolution;Face;fetal;Fetal Development;Fetal Growth;Fetus;Funding;Future;Goals;graphical user interface;Growth;Head;Health;Hospitals;Image;Imaging Device;imaging modality;Imaging Techniques;Impaired cognition;improved;improved outcome;in utero;in vivo;indexing;Individual;Infant;Institution;Intracranial Hypertension;Joints;Knowledge;Live Birth;Logistic Regressions;Los Angeles;Magnetic Resonance Imaging;Manuals;Maps;Measures;Methodology;Methods;model development;Modeling;Morphology;morphometry;Motion;Motor;Motor disability;multidisciplinary;Multiple Pregnancy;National Institute of Child Health and Human Development;National Institute of Dental and Craniofacial Research;Neurologic;Organ;Patients;Pediatric Hospitals;Physicians;Positioning Attribute;Pregnancy;programs;quantitative imaging;Research;Research Personnel;Resources;Sampling;sex;Shapes;Standardization;success;Surgical sutures;System;Testing;Thick;Time;tool;treatment planning;Universities;user-friendly;Variant;Work;X-Ray Computed Tomography

PROJECT_TITLE: Early joint cranial and brain development from fetal and pediatric imaging

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Networking and Information Technology R&D (NITRD);Pneumonia;Pneumonia and Influenza

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE  COVID-19 is an ongoing global pandemic affecting many millions of people around the world. We currently have little understanding as to why some individuals develop a severe infection while most do not. This project seeks to achieve this understanding, and is relevant to public health because it can lead to better identification of at-risk individuals and more effective treatments for them.

PI_NAMEs: LAUBENBACHER, REINHARD ;MEHRAD, BORNA  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: 2019-nCoV;3-Dimensional;ACE2;Affect;alveolar epithelium;Animal Model;base;biobank;Biological;Cell Death;Cells;Cessation of life;cohort;Complex;Computer Models;Confocal Microscopy;COVID-19;COVID-19 pneumonia;COVID-19 severity;Cryopreservation;cytokine;Data;digital twin;effective therapy;Engineering;Epidemiologic Factors;Epithelial Cells;Event;Flow Cytometry;FRAP1 gene;Genetic Transcription;Goals;Grant;Heterogeneity;Human;Immune;Immune response;Immunity;Immunology;improved outcome;Individual;individual variation;Infection;Innate Immune Response;innovation;Interferon Type I;Intervention;K-18 conjugate;Literature;Lung;Lung infections;mathematical model;Measurement;Mediating;Minor;Modeling;Molecular;mouse model;mTOR inhibition;multi-scale modeling;Mus;novel;Outcome;outcome disparities;outcome prediction;pandemic disease;Pathway interactions;Persons;Phosphoproteins;population based;Predictive Factor;Predisposition;Production;Protocols documentation;Public Health;Publishing;receptor;Reproducibility;response;Risk;Role;Sampling;SARS-CoV-2 infection;severe COVID-19;Severities;Signal Transduction;Structure of parenchyma of lung;Surgical Models;System;Testing;therapeutic target;three dimensional cell culture;Time;Tissue Donors;Tissue Preservation;Tissues;tool;Transgenic Mice;Transgenic Organisms;Viral;virology;Virus;Work

PROJECT_TITLE: Mechanistic modeling of the innate immune responses of the human lung to understand the inter-individual heterogeneity of COVID-19 pneumonia


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative This 1<23 will design and test a brief intervention for parents and preschool educators to earn their engagement in behavioral interventions for ADHD. The training and research activities will ensure an acceptable intervention and will further the applicants' skills in reducing mental health disparities in preschool.

PI_NAMEs: ZULAUF-MCCURDY, COURTNEY ANNE (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: 6 year old;Academy;acceptability and feasibility;Address;Administrator;Adult;aged;American;Attention deficit hyperactivity disorder;Attitude;Award;behavior change;Behavior Therapy;behavioral health;brief intervention;Child;Child Behavior;Childhood;Chronic;Clinical;Clinical Investigator;clinically significant;community setting;comparison intervention;compliance behavior;Critiques;culturally appropriate intervention;design;Development;Diagnosis;Discover, Design, Build, and Test Framework;Disparity;disparity reduction;Distal;early childhood;Early identification;Early Intervention;Early treatment;effective therapy;Enrollment;Ensure;Environment;experience;Face;field study;Focus Groups;Foundations;Frequencies;Future;Goals;health disparity;Impairment;improved;improved outcome;Individual;innovation;interest;Intervention;Intervention Trial;iterative design;Learning;Life Cycle Stages;Measurement;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Minority;minority children;Modeling;Motivation;National Institute of Mental Health;Nursery Schools;Outcome;Parenting Education;parenting intervention;Parents;Pediatrics;Perception;Phase;Play;Positioning Attribute;prevent;Prevention;Procedures;Program Development;prototype;Psychologist;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Activity;Research Personnel;research study;Resources;response;Role;School Teachers;Schools;service delivery;skills;social determinants;Statistical Models;Strategic Planning;Surveys;Symptoms;teacher;Testing;therapy development;Training;Training Activity;treatment comparison;willingness;Work

PROJECT_TITLE: Iteratively developing and testing a brief, engagement focused intervention for parents and educators: Parent Education Action Response (PEAR)

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]