ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: NARRATIVE The development of the fetus is heavily influenced by the maternal environment, yet little is known about the role of rare maternal microchimeric cells that traffic into the fetus in educating the fetal immune system. These studies will investigate the relationship between the mother’s T cell repertoire throughout pregnancy and the microchimeric T cell graft acquired by the fetus, as well as the effect of microchimeric antigen presenting cells on fetal T cell responses. An increased understanding of the role and function of these maternal cells in shaping the fetal immune system will have significant implications for interventions to improve fetal and neonatal immunity such as maternal immunization prior to or during pregnancy.

PI_NAMEs: HARRINGTON, WHITNEY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Adult;Antibodies;Antigen-Antibody Complex;Antigen-Presenting Cells;antiretroviral therapy;Birth;Blood;Blood Flow Cytometry;Cell Communication;Cell Compartmentation;Cell Separation;Cells;Chronic;Coculture Techniques;cohort;Collection;cytokine;Data;Development;Education;Effector Cell;embryo/fetus antigen;Enrollment;Environment;Event;fetal;Fetal Development;Fetal health;fetal immunity;Fetus;fetus cell;First Pregnancy Trimester;HIV;Human;Immune;immune reconstitution;Immune system;Immunoglobulin G;Immunologics;Impairment;improved;in utero;Infant;Infection;Inflammatory;Inherited;Intervention;Link;lymph nodes;Lymphoid Tissue;maternal immune system;maternal vaccination;monocyte;Mothers;Neonatal;neonatal health;neonatal immunity;novel;offspring;Passive Immunity;peripheral blood;Phenotype;Placenta;Population;postnatal;Predisposition;Pregnancy;Pregnant Women;Preparation;prevent;Production;Proliferating;Prospective cohort;Recovery;Regulatory T-Lymphocyte;response;Role;Sampling;Second Pregnancy Trimester;Secondary to;Shapes;single-cell RNA sequencing;South African;Specificity;T cell response;T-cell diversity;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Time;Umbilical Cord Blood;Viral

PROJECT_TITLE: Education of the fetal immune system by inherited maternal cells


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: IOWA CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The proposed project focuses upon a protein called TRAF3 that prevents abnormal survival and activation of B cells, the type of white blood cell that produces antibodies. Abnormal regulation of B cells contributes to human autoimmune diseases, which can in turn predispose to later development of B cell cancers. Inflammatory processes promote a loss of TRAF3 protein in B cells, which in turn results in enhancement of key signals contributing to autoimmunity; this project will identify these signals and determine how interrupting these pathways can alleviate autoimmunity.

PI_NAMEs: BISHOP, GAIL A. (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Adaptor Signaling Protein;Address;Affect;Age;Aging;American;animal old age;Antibody-Producing Cells;Appearance;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactive B cell;autoreactivity;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Development;B-Cell Lymphomas;B-Lymphocytes;Blood Cells;cancer cell;Cell Compartmentation;Cell Line;Cell Physiology;Cell Survival;cell type;Cells;Chronic;chronic inflammatory disease;Complex;Data;Development;Disease;effective therapy;Event;Future;Genetic;Goals;Hematopoietic Neoplasms;Human;Immunologic Receptors;Immunosuppression;In Vitro;in vivo;Individual;Inflammation;Inflammatory;innate immune function;Interruption;Knowledge;Lead;Leukocytes;Life;Lymphoma;Lymphomagenesis;Malignant Neoplasms;Mediating;Modeling;Molecular;mouse model;Multiple Sclerosis;Mus;Outcome Study;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;Phosphoric Monoester Hydrolases;Phosphotransferases;Post-Translational Protein Processing;pre-clinical;prevent;Process;protein kinase D;Proteins;receptor;receptor binding;Receptor Signaling;receptor-mediated signaling;reduce symptoms;Regulation;Reporting;restraint;Rheumatoid Arthritis;Risk;Signal Pathway;Signal Transduction;Sjogren's Syndrome;stress disorder;Systemic Lupus Erythematosus;targeted treatment;Tissues;TNF receptor-associated factor 3;TNFRSF5 gene;Toll-like receptors;United States National Institutes of Health;Virulence Factors;Work;young adult

PROJECT_TITLE: Regulation of B cell signaling in autoimmunity by TRAF3

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative The science of health and disease has become increasingly complex, requiring highly coordinated research efforts to ask and answer relevant questions and sophisticated environments to train the individuals who will make tomorrow's most important discoveries. This T32 program offers training for predoctoral PhD students and postdoctoral MD and PhD fellows in the most advanced areas of lung science in an integrated fashion, concentrating on providing high quality mentorship in the scientific disciplines most likely to make advancements in the diagnosis and treatment of lung diseases: Immunology & Infection, Development & Regenerative Medicine, and Biomedical Data Sciences.

PI_NAMEs: KOTTON, DARRELL N.;MIZGERD, JOSEPH P (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Biology;Lung;multidisciplinary;programs

PROJECT_TITLE: Biology of the Lung: A Multidisciplinary Program

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Uterine Cancer;Women's Health Research

ORG_CITY: Columbus

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Effects of multilevel factors may underlie disparities in receipt of guideline-concordant endometrial cancer treatment. We will leverage the National Institute on Minority Health and Health Disparities research framework to guide our analyses of the multifaceted sources of treatment disparities. Our study will identify modifiable factors that can be targeted to reduce disparities and improve care for all women.

PI_NAMEs: FELIX, ASHLEY S. (contact)

PROGRAM_OFFICER_NAME: DAVIDOFF, AMY

PROJECT_TERMS: Academy;Adjuvant Therapy;Black race;black women;black/white disparity;Cancer Patient;Cancer Survivor;cancer therapy;Caring;comorbidity;Data;Data Set;Decision Making;Disease Outcome;Disparate;Disparity;disparity reduction;effective intervention;Endometrial Carcinoma;Evidence based intervention;Exhibits;experience;Foundations;Future;Guidelines;hazard;Health;health definition;health difference;Health Disparities Research;health disparity;Healthcare Systems;improved;Individual;Inequity;Intervention;Interview;Knowledge;Link;Literature;Logistic Regressions;Medicare claim;Medicine;Methods;mortality;multilevel analysis;National Comprehensive Cancer Network;National Institute on Minority Health and Health Disparities;Neighborhoods;Operative Surgical Procedures;Outcome;Pathology;Patients;Prediction of Response to Therapy;Predictive Factor;preference;prevent;Provider;Qualitative Methods;Quality of life;Race;racial determinant;racial difference;racial disparity;Recommendation;Research;Respondent;SEER Program;Shapes;Solid Neoplasm;Source;Staging;surveillance data;therapy development;treatment choice;treatment disparity;treatment strategy;Variant;welfare;Woman;Work

PROJECT_TITLE: Multilevel determinants of racial disparities in receipt of guideline-concordant endometrial cancer treatment

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE  The retinoid visual cycle is a multi-step pathway to recycle 11-cis retinal, the active form of vitamin A for forming visual pigments and essential for normal vision. This project is to identify a new and essential enzyme in the visual cycle to recycle 11-cis retinal. The proposed studies will address an important knowledge gap in vision and has potential to contribute to new treatment strategies for blinding diseases caused by the dysfunctional visual cycle.

PI_NAMEs: MA, JIAN-XING  (contact);MOISEYEV, GENNADIY

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 11 cis Retinal;11-cis-Retinol;absorption;Acceleration;Address;adenovirus mediated delivery;Adenoviruses;Adipose tissue;Age;All-Trans-Retinol;Cell membrane;Cells;chromophore;comparative;conditional knockout;CRISPR/Cas technology;Darkness;Disease;enhancer-binding protein AP-2;Enzymes;Esterification;Esters;Gene Delivery;Generations;Genes;Genetic;High Pressure Liquid Chromatography;human old age (65+);Hydrophobicity;improved;inhibitor;Isomerase;Isomerism;Knock-out;Knockout Mice;Knowledge;lecithin-retinol acyltransferase;Light;Lipase;lipid transport;Lipids;Liver;Measures;Monitor;Mus;Mutation;Natural regeneration;novel therapeutic intervention;Oleates;Opsin;Optical Coherence Tomography;overexpression;Pathway interactions;Phospholipase;Photobleaching;Photons;Photophobia;Photoreceptors;Play;Proteins;Recovery;Recycling;Research;response;Retina;Retinal Degeneration;Retinal Dystrophy;Retinal gene therapy;Retinal Pigments;retinal regeneration;Retinoids;retinol isomerase;retinyl esterase;Rhodopsin;Role;RPE65 protein;Signal Transduction;Vision;visual cycle;Vitamin A

PROJECT_TITLE: Studies of retinyl ester hydrolase in the visual cycle

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: Project Narrative: Disease, degeneration or traumatic injury of the nervous system are among the greatest public health concerns in the United States. Adult neural stem cells raise hope that functional regeneration of nervous tissue may be feasible, if we understand the mechanisms that promote adult neurogenesis. This research will lead to improved understanding of aberrant hippocampal neurogenesis, possibly leading to the development of new treatments for mitigating epilepsy.

PI_NAMEs: HSIEH, JENNY  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Ablation;Acute;Address;Adult;adult neurogenesis;Animal Model;Animals;Brain;Brain Injuries;Candidate Disease Gene;Cell Cycle;Cell Maturation;cell motility;Cells;Chronic;clinically relevant;Clozapine;comparison control;Complement;controlled cortical impact;Dendrites;designer receptors exclusively activated by designer drugs;Development;digital;Disease;Epilepsy;Epileptogenesis;experimental study;Extracellular Matrix;Frequencies;Functional Regeneration;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Regulation;Generations;Genes;granule cell;Hilar;Hippocampus;Hypertrophy;Immunohistochemistry;improved;Injury;Laboratories;Ligands;loss of function;Maps;medial temporal lobe;Mediating;migration;Modeling;Molecular;Morphology;mossy fiber;Motion;mouse model;Mus;nerve stem cell;Nerve Tissue;Nervous System Disorder;Nervous System Trauma;nestin protein;neurogenesis;Neurons;novel;older adult;Oxides;Pathway interactions;pharmacologic;Pilocarpine;Post-Traumatic Epilepsy;Process;Production;programs;Public Health;Publishing;Receptor Activation;Recurrence;Regulation;Regulatory Pathway;Research;Retroviridae;Role;Seizures;Signal Pathway;Signaling Molecule;Status Epilepticus;Temporal Lobe Epilepsy;Testing;therapeutic target;Thymidine Kinase;TIMP3 gene;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;Translating;Traumatic Brain Injury;Traumatic injury;United States;Wild Type Mouse;Work

PROJECT_TITLE: Molecular control of aberrant adult-born granule cells in epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Cushing Disease (CD) is a life-threatening “orphan disease” caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma. Translational research has been limited by lack of pituitary corticotroph tumor models. We have developed a unique 3-dimensional (3D) corticotroph tumoroid culture system that can maintain differentiated ACTH-secreting pituitary corticotroph tumor cells and will utilize it as a preclinical model in a HTS to define and characterize novel drugs for clincal use in CD.

PI_NAMEs: HEANEY, ANTHONY P (contact)

PROGRAM_OFFICER_NAME: BENAVIDEZ, JUSTIN MICHAEL

PROJECT_TERMS: 3-Dimensional;Adrenal Glands;angiogenesis;Architecture;Automobile Driving;biobank;Blood;Catabolism;Cell Adhesion;Cell model;Cells;cheminformatics;Clinical;Collagen;Corticotropin;Development;Disabling;Disease;drug discovery;Drug Interactions;Drug Screening;drug sensitivity;Evaluation;exome sequencing;experience;experimental study;Extracellular Matrix;functional genomics;Genes;Genetic;genomic platform;Genomics;Growth;high throughput screening;high-throughput drug screening;Hormone secretion;Human;Hydrocortisone;Immune response;immunocytochemistry;improved;Individual;individual patient;inhibitor;Libraries;Life;Maps;Medical;Methods;miniaturize;Modeling;Molecular;Monitor;multidisciplinary;neoplastic cell;novel therapeutics;Operative Surgical Procedures;Pathway interactions;Patients;Pattern Recognition;personalized medicine;Pharmaceutical Preparations;Pharmacotherapy;Pituitary Gland;Pituitary Gland Adenoma;Pituitary Neoplasms;Pituitary-dependent Cushing's disease;Pre-Clinical Model;Primary Neoplasm;Production;Proteins;Rare Diseases;Resected;Resources;screening;Screening Result;Serial Passage;Signal Transduction;single-cell RNA sequencing;small molecule;Structure;System;Testing;Time;Tissues;transcriptome;transcriptomics;Translational Research;tumor;Tumor Tissue;Validation;Visualization

PROJECT_TITLE: Development of 3-dimensional human pituitary corticotroph tumor cultures as a preclinical model for drug discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-N(55)R]


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Hematopoietic stem cells (HSCs) have the ability to generate all blood cell types and are the cornerstone of bone marrow transplantation. Despite extensive research on how HSCs become committed to mature blood cells, metabolic cues that instruct HSCs to commit to the erythroid lineage remain unknown. Our study aims to unravel how iron affects the erythroid gene expression and erythroid differentiation of HSCs.

PI_NAMEs: NAKADA, DAISUKE  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Affect;alpha ketoglutarate;Anemia;Biological Assay;Blood Cells;Bone Marrow;Bone Marrow Transplantation;Cell Lineage;cell type;chemotherapy;cofactor;Cues;demethylation;design;differentiation in vitro;Dioxygenases;Disease;DNA;Erythrocytes;Erythroid;erythroid differentiation;Erythropoiesis;Exhibits;experimental study;Gene Expression;Genes;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;hematopoietic stem cell fate;Hematopoietic Stem Cell heterogeneity;Hematopoietic stem cells;Hematopoietic System;Hemolytic Anemia;Hemorrhage;Heterogeneity;Homeostasis;Hypoxia;in vivo;Inflammation;injury recovery;insight;Iron;Iron Chelating Agents;Iron Chelation;Label;Mediating;Metabolic;Modeling;Mus;Natural regeneration;novel;novel strategies;novel therapeutic intervention;Phosphorylation;Phosphotransferases;prevent;protein expression;Proteins;Regenerative Medicine;Research;response;Role;self-renewal;Shapes;Signal Transduction;single-cell RNA sequencing;Source;Spleen;stem cell population;Stress;stressor;Testing;TFRC gene;Transfusion;Transplantation;uptake

PROJECT_TITLE: Mechanisms that regulate erythroid differentiation of hematopoietic stem cells

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Project Narrative Medical imaging can be used to study heart valve disease by measuring blood flow, but current methods are not always accurate. Magnetic Resonance Imaging (MRI) has many potential advantages over other methods, but MRI is too slow to measure blood flow in a volume. In this project, we will develop a faster method to image the blood flow; these efforts should lead to significant improvements in the assessment of heart valve disease so that patients may benefit from appropriate treatment.

PI_NAMEs: AHMAD, RIZWAN  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: 4D MRI;Acceleration;Acoustics;aging population;Aortic Valve Insufficiency;Aortic Valve Stenosis;Bayesian Modeling;Blood;Blood flow;cardiac magnetic resonance imaging;Cardiovascular system;Clinical;clinical care;clinical outcome assessment;Clinical Research;cohort;Complex;computer framework;computerized data processing;cost effective;data acquisition;Dependence;Diagnosis;Diagnostic Imaging;Echocardiography;EFRAC;Evaluation;Exercise;ferumoxytol;Functional disorder;Functional impairment;Goals;Health;healthy volunteer;Heart;heart function;heart imaging;heart rhythm;Heart Valve Diseases;Image;Imaging Techniques;Impairment;improved;innovation;interest;Intervention;Lateral;Lesion;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Medical Imaging;Methods;Mitral Valve Insufficiency;Motion;Movement;multimodality;Myocardial;Operative Surgical Procedures;Outcome;Patients;Phase;Physiologic pulse;Physiological;Play;Positron-Emission Tomography;predict clinical outcome;Predisposition;Prevalence;protocol development;Protocols documentation;Public Health;Recommendation;reconstruction;Reproducibility;Research;Research Personnel;Resolution;Rest;risk stratification;Role;Scanning;Severities;signal processing;Signal Transduction;Signs and Symptoms;standard of care;Stress;Stress Tests;Techniques;Time;tool;Transesophageal Echocardiography;treatment planning;Validation;vector;Ventricular;VO2max;Work

PROJECT_TITLE: A comprehensive valvular heart disease assessment with stress cardiac MRI

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Mental Health;Neurosciences;Pediatric;Prevention;Sleep Research;Substance Misuse;Underage Drinking

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Heavy alcohol drinking during adolescence is known to disturb brain development and functioning and increase risk of drinking problems in adulthood, but the extent of the lingering effects of youthful drinking on adult functioning remains unclear. The goal of NCANDA-A (Adulthood) is to determine how adolescent alcohol-related disruption of normal brain growth patterns of brain structure, function, and psychiatric health affects abilities in emerging adulthood. Determining which affected processes remain impaired and which escape alcohol's untoward effects will specify how a youthful drinking history influences quality of life in adulthood, information obtained only from longitudinal study as proposed by NCANDA-A.

PI_NAMEs: GOLDSTON, DAVID B. (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: 21 year old;Abstinence;Acceleration;Acute;Adolescence;Adolescent;adolescent binge drinking;Adult;Adverse effects;Affect;Affective;Age;Alcohol abuse;Alcohol consumption;alcohol cue;alcohol effect;alcohol expectancy;alcohol use disorder;alcohol use initiation;Alcohols;Behavioral;binge drinking;Biological;Brain;Clinical;Cognition;Cognitive;cognitive control;cognitive performance;cohort;Communities;Computers;COVID-19 impact;COVID-19 pandemic effects;cue reactivity;Data;design;Development;Distress;Dose;drinking;drinking onset;early onset;Economics;Elements;emerging adult;emerging adulthood;Emotional;Event;experience;externalizing behavior;Family;Female;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Goals;gray matter;Growth;Health;heart function;Heart Rate;Heavy Drinking;Home;Impairment;improved;Individual;information processing;Learning;Life;Life Stress;Link;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;male;Measures;Mediating;medical specialties;Memory;Mission;mobile application;Modeling;modifiable risk;Monitor;multimodal neuroimaging;neural;neurodevelopment;neuroimaging;neuropsychiatry;novel;Outcome;Outcome Measure;pandemic disease;Patient Recruitments;Pattern;Personal Satisfaction;Persons;Physical activity;Polysomnography;Positioning Attribute;post-pandemic;pre-pandemic;Process;Protocols documentation;Psychopathology;Psychosocial Factor;Quality of life;Recording of previous events;Recovery;recruit;Research Project Grants;response;Rest;retention rate;Risk;Risk Factors;Sampling;Schools;Sex Differences;Sex Differentiation;Site;Sleep;Sleep disturbances;social;Specific qualifier value;Stress;Structure;Symptoms;System;Technology;Testing;underage drinking;Work

PROJECT_TITLE: NCANDA Research Project Site: Duke


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Unanticipated adverse drug reactions remain a major cause for restricted access to new medications and post marketing withdrawals of new drugs. Adverse drug reactions are often caused by reactive metabolic species that form covalent adducts with proteins but the identitiy and extent of protein adducts formed is often difficult to predict or prevent. This project will establish novel proteomics tools that can be used to evaluate mechanisms of adverse drug reactions and that can be incorporated into drug development workflows for early identification of drug protein adducts.

PI_NAMEs: ISOHERRANEN, NINA  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: access restrictions;Accounting;Address;adduct;adverse drug reaction;Adverse event;Amino Acids;Biochemical;Biological;Biological Markers;Calibration;Catalogs;Cells;Characteristics;Chemicals;Chlorine;Clinical;clinically relevant;Complex;Computer software;Cytochrome P450;Data;design;Detection;Development;Discipline;drug development;drug discovery;drug withdrawal;Early identification;enzyme mechanism;Enzymes;Event;Exposure to;Fractionation;Gases;Genotype;Goals;Hepatocyte;high dimensionality;Human;In Situ;In Vitro;Incubated;Individual;innovation;Insecta;insight;inter-individual variation;ion mobility;Isotope Labeling;Isotopes;Label;Life;Liver;Liver Microsomes;Mass Spectrum Analysis;medication safety;Membrane;Metabolic;Metabolic Activation;Methods;Modeling;Modification;novel;novel therapeutics;Pathway interactions;Patients;Peptides;Performance;Pharmaceutical Preparations;Phase;post-market;Post-Translational Protein Processing;Preparation;prevent;Protein Secretion;Protein Structure Initiative;Proteins;Proteome;Proteomics;rapid technique;Recombinants;Reference Standards;Research;Resolution;risk mitigation;Safety;safety assessment;Sampling;Software Validation;Spectrometry;System;targeted treatment;Technology;Testing;therapy design;tool;Toxic effect;toxicant;Translating;Translational Research;Variant;Withdrawal;Work;Xenobiotics

PROJECT_TITLE: Identification and quantification of drug-protein adducts by mass spectrometry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-H(02)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Serious Mental Illness;Stroke

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARATIVE: Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptoms Depression is the leading cause of disability worldwide and identifying the brain regions causing depression symptoms can lead to better, more targeted treatments. Here, we leverage a technique recently developed by our group to identify the brain regions causing depression symptoms and mediating symptomatic relief based on a unique combination of focal brain lesions, focal brain stimulation, and maps of human brain connectivity. Completion of this project will provide biomarkers for predicting post-stroke depression, evaluating future depression therapies, and optimal therapeutic targets for invasive and noninvasive brain stimulation.

PI_NAMEs: FOX, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Admission activity;Age;anti-depressive agents;Behavior;Brain;Brain hemorrhage;Brain region;Clinical;clinical practice;Clinical Trials;cohort;compulsion;Computer software;connectome;Data;Data Set;Deep Brain Stimulation;depressive symptoms;Diagnosis;Diagnostic;diagnostic value;disability;Enrollment;Epilepsy;Functional Magnetic Resonance Imaging;Future;Goals;Human;Human Characteristics;improved;individual patient;Ischemic Stroke;large datasets;Lead;Lesion;Link;Location;Magnetic Resonance Imaging;Major Depressive Disorder;Maps;Mediating;Mental Depression;Modality;Motor;National Institute of Mental Health;Neuroanatomy;neuroimaging;Neuronavigation;neuroregulation;noninvasive brain stimulation;Obsession;Obsessive-Compulsive Disorder;Outcome;Parkinson Disease;Patients;Pattern;Pharmaceutical Preparations;physically handicapped;post stroke;post stroke depression;Postoperative Period;predictive marker;prospective;Prospective Studies;prospective test;Publishing;Recording of previous events;response;Rest;Seizures;sex;Site;Source;stroke outcome;stroke trials;Symptoms;Techniques;Testing;Therapeutic;therapeutic target;Time;Transcranial magnetic stimulation;Translating;United States National Institutes of Health;Validation;Work;X-Ray Computed Tomography

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Infectious diseases are the third most common cause of death in the United States, despite availability of antibiotics, vaccines, and high standards of public health, and the leading cause of death worldwide. Our program supports training of infectious diseases specialists in laboratory and clinical sciences to prepare them for careers in academia, industry, and the public health sector in the treatment, control, and prevention of infectious diseases.

PI_NAMEs: DORSEY, MATTHEW G (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Biology of Infectious Diseases Training Program

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Blood transfusion is a critical component of healthcare, as evident by the 10 million-plus units of red blood cells (RBCs) administered to people on an annual basis in the United States alone. In this application, a team of investigators proposes that a slight modification to the solutions used to store RBCs for up to 42 days in the United States, specifically, a reduction in the amount of glucose (sugar) initially placed in the storage bag, will result in an improved storage product. We propose this modification, which will not interfere with the current simplicity of how blood collection is performed, will result in reduced post-transfusion complications, and extend the shelf-life of the stored cells by up to 14 days, saving an estimated 12,000 units of blood from expiration during that timeframe.

PI_NAMEs: MCMAHON, TIMOTHY J;SPENCE, DANA M (contact);ZINN, KURT R

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: 3D Print;Accidents;Adhesions;Advanced Development;Advanced Glycosylation End Products;Amino Acids;Animal Model;Animals;Autologous;Biological;Blood;Blood Donations;Blood flow;Blood Glucose;blood product;Blood Transfusion;C-Peptide;cancer therapy;Cell Adhesion;cell growth;Cell membrane;Cell Survival;Cell Volumes;Cells;chemical property;Chemicals;Circulation;Collection;COVID-19 pandemic;Cytolysis;Data;design;Detection;Devices;Diabetes Mellitus;Emergency Care;Endothelial Cells;Endothelium;Erythrocyte Transfusion;Erythrocytes;expiration;fabrication;FDA approved;feeding;Fiber;Fluorescence;Foundations;Gamma Rays;Glucose;Health Personnel;Healthcare;Hospitals;Human;Hyperglycemia;Image;improved;In Vitro;in vivo;Infection;Insulin;Intravenous;Label;Lead;Lesion;Life;Lung;Maintenance;Manuals;Measures;Membrane;Metabolic;Methods;Microfluidic Microchips;Modeling;Modification;Molecular Analysis;Monitor;mouse model;Nitric Oxide;novel;Outcome Study;oxidation;Oxygen;pancreatic juice;Patients;Peptides;Performance;Periodicals;Persons;physical property;Physiological;Printing;Property;Protocols documentation;prototype;Radiolabeled;radiotracer;Reagent;Rejuvenation;Reporting;Research Personnel;Saline;Sheep;sheep model;Sickle Cell Anemia;sugar;supply chain;Surveys;System;Technetium;Techniques;Testing;Time;Transfusion;transfusion medicine;Trauma;United States;vascular bed;Vascular blood supply;Whole Blood

PROJECT_TITLE: An Improved Red Blood Cell Storage Product and Extended Shelf Life using a Normoglycemic Additive Solution

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Impaired metabolism is known to be strongly associated with a metabolically induced inflammation with an increase in white blood cells called myeloid cells (monocytes/macrophages) in animal models and studies in adults. However, risk for these diseases and inflammatory responses to obesity are not uniform and further identification of who is at risk could potentially prevent disease manifestation. This proposal seeks to evaluate if circulating monocyte gene expression and phenotype can characterize adolescents with obesity with a risk for meta-inflammation and if nutritional fatty acids can modify this risk.

PI_NAMEs: SINGER, KANAKADURGA  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Adolescent;Adolescent obesity;Adult;adult obesity;Animal Model;Animals;Antigen Presentation;Automobile Driving;boys;Cardiovascular Diseases;CD14 gene;Cell Maturation;Cells;Child;Childhood;Clinical;Clinical Research;clinically significant;cytokine;Data;Diabetes Mellitus;diabetes risk;Diet;Dietary Fats;Dietary Fatty Acid;Disease;disorder risk;Eicosanoids;Ensure;Evaluation;fatty acid oxidation;Fatty Acids;Female;Female Adolescents;Flow Cytometry;Functional disorder;Future;Gene Expression;girls;Glycosylated hemoglobin A;Hematopoietic;Heterogeneity;high risk;Human;Hypertriglyceridemia;Immune;Impairment;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;innovation;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Intervention;ITGAX gene;Knowledge;leukocyte activation;Leukocytes;Life;Link;Lipids;Lipopolysaccharides;Lymphocyte;Macrophage;Male Adolescents;Measures;men;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Modeling;monocyte;Mus;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Myelopoiesis;Non-Insulin-Dependent Diabetes Mellitus;Nutritional;Obesity;obesogenic;Outcome;Pathway interactions;Phenotype;Population;preclinical study;predictive marker;Prevalence;prevent;Production;progenitor;Prostaglandins;recruit;Reproducibility;response;Risk;Risk Factors;Role;Saturated Fatty Acids;segregation;Sorting;stem cells;Thinness;Tissues;TLR4 gene;trafficking;transcriptome sequencing;transcriptomics;Translating;translational approach;United States;uptake;Vulnerable Populations;Weight;Woman

PROJECT_TITLE: The role of circulating meta-inflammatory monocytes in adolescent insulin resistance

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE The proposed project is relevant to public health in that it is expected to identify and characterize gene expression regulators that are essential for the development of sensory cells in the hearing organ, and to thereby advance our knowledge in the field of audiology. The resulting improvement in our understanding of the pathophysiology of the hearing organ is expected to support efforts to induce regeneration of sensory cells in the hearing organ of deaf subjects.

PI_NAMEs: BANFI, BOTOND  (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Affect;Age;Alternative Splicing;Audiology;Cell Maturation;Cell Survival;cell type;Cells;Cellular Morphology;Cochlea;cochlear development;Data;deaf;deafness;design;Development;Disease;Down-Regulation;Epithelium;Event;Exons;Functional disorder;Funding;Gene Expression;gene interaction;Gene Silencing;Genes;Genetic Transcription;Goals;hair cell regeneration;Hair Cells;Hearing;hearing impairment;HMGB Family Gene;Homologous Gene;human old age (65+);improved;Individual;Knock-out;knockout gene;Knockout Mice;Knowledge;life span;Measures;Mediating;Methods;Mus;Mutagenesis;Mutation;Natural regeneration;Neurons;Newborn Infant;novel;Organ;Organ of Corti;Outcome Study;Outer Hair Cells;Perinatal;Phase;Physiological;prenatal;prevent;Production;programs;Public Health;rational design;RE1-silencing transcription factor;Regulation;Repression;Repressor Proteins;Research;RNA Splicing;Role;Sensory;somatic cell gene editing;Testing;Thymocyte Selection;transcription factor;Transcription Repressor;Transcriptional Regulation;transcriptome sequencing;Transgenes;Viral Vector;Zinc Fingers

PROJECT_TITLE: Transcriptional regulation of hair cell development in the hearing organ

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Asthma;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: NARRATIVE The overall goal of this project is to decipher the epigenome and socio-environmental exposure determinants of asthma by carrying out genome-wide Methyl-Seq at more than 3.7 million CpG sites, incorporating geocoded neighborhood- and individual- level socio-environmental predictors and existing multi-ethnic genotyping array (MEGA) data, and using novel analytical strategies to create an ancestry-specific methylation risk score (MRS) followed by composite risk prediction by incorporating MRS, genetic ancestry, clinical, and socio-environmental exposure risk factors. The study will provide insights in the use of risk stratification in asthma and will likely provide a model composite risk system in other well-documented common complex diseases beyond asthma.

PI_NAMEs: MERSHA, TESFAYE B. (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Address;Affect;African American;African American population;Age;Air Pollution;Algorithms;Allergens;American;Asthma;asthma model;asthmatic;biobank;Bioinformatics;Biological;Biometry;Caring;Cells;Child;Childhood;Childhood Asthma;Clinic;Clinical;clinical predictors;clinical risk;Clinical Sciences;cohort;Communities;Complex;Data;deprivation;Disease;DNA analysis;DNA Methylation;DNA methylation profiling;DNA Modification Process;Economic Conditions;Environmental Exposure;Epigenetic Process;epigenetic variation;epigenome;epigenome-wide association studies;European;Exposure to;Gene Frequency;gene function;Genetic;Genetic Predisposition to Disease;Genome;genome wide methylation;genome-wide;Genotype;Geography;Goals;Green space;Hospitalization;Hypersensitivity;Immune;improved;Incidence;indexing;Individual;innovation;insight;Intervention;Link;Maps;Measures;Mediating;Mediation;Methylation;methylation pattern;Minority;Modeling;multi-ethnic;Neighborhoods;non-genetic;novel;Ohio;Pathogenesis;Pediatrics;Phenotype;population based;predictive modeling;programs;psychosocial;Public Health;racial disparity;repository;Research;Research Personnel;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;Sampling;Science;screening;sex;Site;social;Social Characteristics;Social Environment;social epidemiology;socioeconomics;Statistical Methods;Stress;Study models;Sum;Surrogate Markers;System;Testing;Time;Tobacco smoke;United States;United States National Institutes of Health;Variant;Violence;Work

PROJECT_TITLE: Epigenome-wide variations and socio-environmental exposures in African American asthmatic children


ADMINISTERING_IC: DA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Narrative Policy makers and policy researchers remain challenged by the rapidly evolving opioid-related public health crisis. The RAND-USC Schaeffer Opioid Policy Tools and Information Center (OPTIC) is a national resource, fostering innovative research in the opioid policy arena and developing and disseminating methods, tools, and information to the research community, policymakers, other stakeholders, and the general public.

PI_NAMEs: STEIN, BRADLEY D (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: 2019-nCoV;Achievement;addiction;Address;Adopted;Advocate;Affect;Area;Buprenorphine;Collection;Communities;COVID-19 pandemic;Data;Data Set;design;Development;Dimensions;Disparity;Disparity population;effective therapy;Effectiveness;Elements;ethnic disparity;Fatality rate;Fentanyl;Fostering;General Population;Goals;Grant;Growth;health inequalities;Illicit Drugs;illicit opioid;improved;Individual;Inequality;Inequity;Information Centers;innovation;Institution;Institutional Racism;Knowledge;Laws;Lead;Methodology;Methods;models and simulation;multidisciplinary;Naloxone;Nature;Opioid;Opioid Analgesics;opioid epidemic;opioid overdose;opioid policy;opioid use disorder;Outcome;overdose death;Overdose reversal;Pain management;Pharmaceutical Preparations;Policies;Policy Maker;Policy Making;Policy Research;Population;Population Heterogeneity;prescription monitoring program;prescription opioid;prevent;Public Health;racial disparity;recovery services;Research;Research Personnel;Resources;Risk;Science;Series;simulation;social;societal costs;Speed;Substance abuse problem;Substance Use Disorder;Swelling;synthetic opioid;Talents;Time;tool;treatment services

PROJECT_TITLE: Center to Advance Research Excellence (OPTIC)


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: 2019-nCoV;Accident and Emergency department;Address;Adherence;Admission activity;Adopted;Affect;arm;Collaborations;Communication;Communities;community center;Congresses;COVID-19;COVID-19 pandemic;Data;Data Set;data visualization;Dedications;Development;digital;Economic Burden;Educational Materials;Educational workshop;effective therapy;Emergency Situation;Ensure;Environment;Ethics;Fatality rate;federal policy;Feedback;Fostering;Funding;Grant;Hand;improved;Individual;Inequality;Information Centers;Infrastructure;Institutional Racism;medical specialties;meetings;Methodology;Methods;Monitor;multiple drug use;Naloxone;Newsletter;Opioid;Opioid Analgesics;opioid epidemic;opioid overdose;opioid policy;opioid use;opioid use disorder;Pattern;Pharmaceutical Preparations;Pilot Projects;Policies;Policy Maker;Policy Making;Policy Research;Population;Problem Solving;Procedures;Process;Public Health;Publications;Publishing;Quality Control;Regulation;Reporting;Research;research data dissemination;Research Personnel;Research Project Grants;Resources;Science;Scientist;Senior Scientist;Series;Site;Stimulant;Structure;Substance Use Disorder;symposium;synergism;synthetic opioid;timeline;tool;United States;Update;web site;webinar;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

PHR: Project Narrative Currently, a large number of Lassa virus and other arenavirus infections cannot be diagnosed because no existing point of care diagnostic assays can detect infection with the required level of sensitivity. The proposed studies will result in a panel of diagnostic antibodies that can detect all circulating Lassa virus strains, the first point-of-care assay for Lassa virus infection with the sensitivity to support case detection, surveillance, and outbreak response, and broadly reactive high affinity diagnostic antibody pairs the 5 other arenaviruses that are Category A Priority Pathogens. This will address a critical global health need by allowing the accurate diagnosis of Lassa fever in all settings, markedly improving the care and management of Lassa fever patients, and facilitating the timely control of all arenavirus outbreaks

PI_NAMEs: GUNN, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: accurate diagnosis;Address;Affinity;Africa;Animal Model;Antibodies;Antibody Affinity;antibody detection;antibody diagnostic;antibody libraries;Antigens;Archives;Arenavirus;Arenavirus Infections;assay development;Biological Assay;bioweapon;Blood;Bolivian Hemorrhagic Fever Virus;Caring;Case Fatality Rates;Categories;Category A pathogen;Cessation of life;Chapare Virus;Clinical;Clinical Sensitivity;COVID-19;Death Rate;Detection;Development;Diagnosis;Diagnostic;diagnostic assay;diagnostic panel;Diagnostic Reagent;Diagnostic Sensitivity;diagnostic value;Disease;Disease Outbreaks;Ebola;Ebola virus;Emerging Communicable Diseases;emerging pathogen;Epidemic;experience;Family;Future;Generations;Genetic Variation;global health;Glycoproteins;Health;hemorrhagic fever virus;Human;Immunoassay;improved;Infection;Junin virus;Laboratories;Lassa;Lassa Fever;Lassa virus;Libraries;Lujo virus;member;Methods;Morbidity - disease rate;mortality;Nigeria;novel;outbreak response;pandemic disease;pandemic potential;Patients;Phage Display;point of care;point of care testing;point-of-care diagnostics;Primates;Printing;priority pathogen;Procedures;prospective;prototype;public health emergency;Reader;Readiness;Reporting;research and development;Reverse Transcriptase Polymerase Chain Reaction;Risk;Sampling;Sensitivity and Specificity;Serum;Site;Source;Specificity;Technology;Testing;transmission process;United States National Institutes of Health;Vaccines;Validation;Venezuelan hemorrhagic fever virus;Viral;Viral Hemorrhagic Fevers;Viral Proteins;Virus;Virus Diseases;Work;World Health Organization;Zoonoses

PROJECT_TITLE: Development of point-of-care testing for Lassa and other hemorrhagic fever arenaviruses

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

PI_NAMEs: PACULA, ROSALIE LICCARDO (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Affect;Area;Attention;Censuses;Communication;Communities;Community Health;community-level factor;Complex;coronavirus disease;County;Data;data library;data resource;Data Set;Development;drug misuse;education resources;Educational Materials;Educational workshop;Effectiveness;effectiveness evaluation;Ensure;Environment;Ethnic Origin;Evaluation;experience;Explosion;Health Insurance;high risk;Housing;Human Resources;illicit opioid;improved;Income;Infrastructure;innovation;Insurance Coverage;Interruption;Investigation;Knowledge;Light;Literature;Measurement;Measures;Mentors;Methodology;Methods;mindfulness;Nature;Neighborhoods;non-opioid analgesic;Occupations;Opioid;opioid epidemic;opioid misuse;opioid policy;Outcome;Persons;Play;Policies;Policy Maker;Public Health;Publishing;Race;repository;Research;Research Personnel;Resources;Review Literature;Risk;Role;Scanning;Scientist;Shapes;social;social disparities;social structure;Socioeconomic Status;socioeconomics;Speed;structural determinants;Structural Racism;substance misuse;Techniques;Testing;Time Series Analysis;timeline;tool;Training;treatment effect;Trust;Update;vulnerable community;Wages;Work

PROJECT_TITLE: Data and Methods Core


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: Public Health Narrative The proposal seeks to address key obstacles that must be overcome to achieve enzyme-less nanopore-based low-cost high-speed sequencing of chromosomal length DNA molecules. Fast and low cost full genome DNA sequencing will allow, for example, major improvements in the understanding, diagnosis, treatment and pre- vention of disease, and significant advances in evolutionary research and the understanding of cellular opera- tion.

PI_NAMEs: DRNDIC, MARIJA ;SHEPARD, KENNETH L (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TITLE: Enzymeless, controlled electrostatic ratcheting in solid-state nanopores


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The proposed work leverages a unique birth cohort with repeated longitudinal follow-ups and brain magnetic resonance imaging to examine the influence of phthalate and bisphenol exposures on executive function and behavior in adolescents. Understanding the effects of chemical exposures on adolescent brain is important because this period of life might present considerable opportunity for exposure reduction. If the adolescent brain is found to be affected by chemicals then guidance in regulations of environmental exposure beyond the prenatal period might be indicated.

PI_NAMEs: GHASSABIAN, AKHGAR  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Adolescence;Adolescent;adolescent brain development;Affect;Age;Aggressive behavior;Androgen Receptor;androgenic;Androgens;Attention;Attention deficit hyperactivity disorder;Behavior;Birth;Blood specimen;Brain;brain magnetic resonance imaging;brain morphology;Cell Differentiation process;Chemical Exposure;Chemicals;Child;Childhood;Cognition;cohort;Complement;Data;Decision Making;Development;Diethylhexyl Phthalate;Disinhibition;early adolescence;early childhood;emerging adult;Emotional;empowerment;Endocrine Disruptors;Enrollment;Environment;Environmental Exposure;Estrogens;Executive Dysfunction;executive function;Exposure to;Failure;follow up assessment;follow-up;Functional disorder;Generations;Goals;Gonadal Steroid Hormones;gray matter;Growth;Head circumference;Hormonal;Hormonal Change;Hormones;Impairment;Impulsivity;in utero;Intervention;Life;Life Cycle Stages;Literature;Long-Term Effects;Magnetic Resonance Imaging;Male Adolescents;Measures;Mediating;Mothers;myelination;neurodevelopment;neurogenesis;Neuroglia;neuroimaging;Neuropsychology;neurotoxic;neurotoxicity;Parietal Lobe;Participant;phthalates;Play;Population;postnatal;Predisposition;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Problem behavior;Process;Regulation;response;Risk Taking;Sample Size;Sampling;sex as a biological variable;Short-Term Memory;Structural defect;Structure;synaptic pruning;Testosterone;Thick;thyroid disruption;Thyroid Function Tests;Thyroid Gland;Thyroid Hormones;Time;urinary;Urine;white matter;Work

PROJECT_TITLE: Brain Influences of Phthalates and Bisphenols in Adolescents

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

PI_NAMEs: SMART, ROSANNA  (contact)

PROJECT_TERMS: 2019-nCoV;addiction;Address;Adopted;Adoption;Area;Attention;Behavior;Behavioral Sciences;Categories;Classification;Communities;COVID-19 pandemic;Criminal Justice;Data;Data Collection;data infrastructure;data resource;Data Set;Development;Drug usage;Employment;Environment;Epidemiology;Evidence based treatment;Evolution;Fentanyl;Future;Goals;Government;Grant;Health;Health Services Accessibility;Healthcare;Heroin;Housing;illicit opioid;implementation determinants;implementation science;Improve Access;improved;Individual;Laws;Legal;manufacture;Maps;Measures;Methods;Modeling;Morbidity - disease rate;mortality;Opioid;Opioid Analgesics;opioid epidemic;opioid misuse;opioid overdose;opioid policy;opioid use disorder;opioid user;Organizational Policy;Outcome;overdose death;overdose prevention;Pattern;Personal Satisfaction;Pharmaceutical Preparations;Policies;Policy Developments;Policy Maker;Policy Making;prescription drug abuse;prescription monitoring program;prescription opioid;prevent;Public Health;Publishing;Race;racial disparity;rapid growth;Reporting;Research;Research Personnel;residential segregation;Resources;response;Risk;Role;Shapes;social;Social Policies;Stimulant;Structural Racism;substance misuse;substance use;Substance Use Disorder;success;synthetic opioid;System;Taxonomy;Time;Training Programs;Work

PROJECT_TITLE: A Framework for Understanding Mechanisms of Policy Change: The Opioid Policy Taxonomy


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Radiation Oncology;Rare Diseases

PHR: PROJECT NARRATIVE In this proposal we aim to investigate two key metabolic players that mediate metabolic plasticity in cancer cells during and after radiation that ultimately result in therapy resistance. The oxidative stress induced by radiation activates NRF2, the master regulator of cellular antioxidant response, but it inactivates the glycolytic enzyme PKM2, with the ultimate result of rewiring of cellular metabolism in a way that supports an antioxidant response. Interfering with the PKM2 function and the NRF2 pathway has the potential to sensitize GBM to RT.

PI_NAMEs: VLASHI, ERINA  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Address;Affect;Antioxidants;Automobile Driving;Back;blood-brain barrier crossing;brain tissue;cancer cell;cancer type;Carbon;Cell Nucleus;Cell Survival;Cells;Cellular Metabolic Process;Characteristics;Clinic;combat;Consumption;Cytoplasm;Data;Defense Mechanisms;Dependence;Disabling;Disease;Disease Outcome;Dose;Dose Fractionation;effective therapy;Enzymes;Erythroid;flexibility;frontier;Genes;Glioblastoma;Glioma;Glucose;glucose metabolism;Glutamine;Glutathione Disulfide;Glycolysis;Goals;Homeostasis;Human;human model;improved;improved outcome;In Vitro;in vivo;inorganic phosphate;Investigation;Ionizing radiation;Knowledge;Mediating;Metabolic;metabolic phenotype;Metabolism;Modality;Molecular Conformation;mouse model;NADP;Normal Cell;novel;Nuclear;overexpression;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Patients;Pentosephosphate Pathway;Phosphotransferases;prevent;Production;programs;Proliferating;Protein Isoforms;Pyruvate Kinase;Radiation;radiation effect;Radiation Oncology;radiation resistance;radiation response;Radiation therapy;Recurrence;Recycling;Regimen;Resistance;response;Role;Route;Shunt Device;small molecule;Specimen;stem cells;Supporting Cell;System;Testing;Therapeutic;therapy outcome;therapy resistant;Time;transcription factor;Transcription Initiation;Translations;Treatment Failure;tumor;tumor metabolism;tumor microenvironment;uptake

PROJECT_TITLE: Drivers of metabolic plasticity promote radiation resistance in glioblastoma multiforme

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative We propose to develop a platform technology to drug-load CAR T cells with nanocarriers, thus enhancing the therapeutic window of CAR T cells, and addressing one of the major obstacles to CAR T cells in brain tumors.

PI_NAMEs: AKHAVAN, DAVID  (contact);BOSSMANN, STEFAN H

PROGRAM_OFFICER_NAME: SALOMON, RACHELLE

PROJECT_TERMS: Address;Adjuvant;Adoptive Cell Transfers;Adult;Affect;Antibody Specificity;Biochemical;Brain Neoplasms;CAR T cell therapy;cell killing;Cell Physiology;Cell Survival;Cells;Cessation of life;chemoradiation;chimeric antigen receptor;chimeric antigen receptor T cells;Chimeric Proteins;Clinical;Clinical Trials;comparative efficacy;cytokine;Cytolysis;Data;design;Disease;Doctor of Philosophy;Dominant-Negative Mutation;dosage;drug candidate;Drug toxicity;Drug Utilization;Drug vehicle;Epidermal Growth Factor Receptor;Esters;Evaluation;Excision;experience;FDA approved;Gingiva;Glioblastoma;Goals;Growth Factor Inhibition;Growth Factor Receptors;Half-Life;Hematologic Neoplasms;Hemorrhage;Histiocytosis;Immune;immunotoxicity;improved;In Vitro;in vivo;inhibitor;interest;Intracranial Hemorrhages;invention;Kansas;kinase inhibitor;Label;Laboratories;Life;Macrophage;Malignant neoplasm of brain;Malignant neoplasm of prostate;Malignant Neoplasms;manufacture;Mediating;Modeling;Mus;nanocarrier;Nanotechnology;nanotechnology platform;new therapeutic target;novel;novel therapeutics;Oncogenic;overexpression;Patients;Penetration;Peptides;Pharmaceutical Preparations;Phosphotransferases;Polymers;pre-clinical;Pre-Clinical Model;Principal Investigator;Production;programmed cell death ligand 1;receptor;Recurrence;Reporting;Research;research clinical testing;Resistance;response;Route;small molecule;small molecule inhibitor;Solid Neoplasm;success;systemic toxicity;T cell therapy;T-Lymphocyte;targeted treatment;Technology;technology platform;Testing;Therapeutic;therapeutic target;Toxic effect;Transforming Growth Factors;tumor;tumor eradication;tumor microenvironment;tumor specificity;Universities;Up-Regulation;uptake

PROJECT_TITLE: Design of a Novel Nanocarrier Technology to Drug-Load CAR T cells


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Autosomal dominant conditions are debilitating, and there is no treatment available. CRISPR gene editing as it currently stands is unrealistic to translate to a clinical setting due to the gene- and mutation-specific guide RNA (gRNA) targeting requirements and delivery. Our strategy will address this problem by providing an efficacious way to treat autosomal dominant conditions; identifying and optimizing the ideal CRISPR delivery best suited for these conditions; and enabling treatment in a manner that is not mutation specific.

PI_NAMEs: AUDO , ISABELLE  ;SPARROW, JANET RUTHE;TSANG, STEPHEN H (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Ablation;Acceleration;Adolescent;Affect;Alleles;autosomal dominant mutation;autosome;Cells;Chlorides;Chromosomes;Clinic;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cost;CRISPR therapeutics;CRISPR/Cas technology;Custom;Data;design;Disease;Disease Progression;Drug Kinetics;Engineering;experience;FDA approved;gain of function;Gene therapy trial;Generations;Genes;genetic analysis;Genome;Guide RNA;Heterozygote;Image;imaging biomarker;In Vitro;induced pluripotent stem cell;Inherited;Interphase Cell;Investigational Drugs;Investigational New Drug Application;Investments;loss of function;Macular degeneration;Measurement;membrane-associated placental tissue protein 1;Modification;Monitor;Multimodal Imaging;mutant;Mutation;nonhuman primate;Operative Surgical Procedures;Outcome;Outcome Measure;patient derived induced pluripotent stem cells;Patients;Persons;Pharmacology and Toxicology;Phase;phase I/IIa trial;Rattus;Reagent;repaired;Research;Rhodopsin;Safety;Single Nucleotide Polymorphism;Specificity;stem cells;Structure of retinal pigment epithelium;Supplementation;System;Testing;Therapeutic;therapeutic genome editing;Time;tool;Toxicology;Transcription Initiation Site;Translating;Translations;Transplantation;treatment response;Validation;vector;Vitelliform macular dystrophy;Work

PROJECT_TITLE: Therapeutic gene editing and multimodal imaging in juvenile macular degeneration


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Rural Health;Social Determinants of Health;Substance Misuse

PI_NAMEs: PEET, EVAN DAVID (contact)

PROJECT_TERMS: absorption;Affect;Area;Black race;Characteristics;Child Abuse and Neglect;child protective service;Child Welfare;Communities;cost;Cost Analysis;Cost Measures;Cost-Benefit Analysis;Country;County;COVID-19 pandemic;Crime;Databases;Dependence;design;Direct Costs;divorce/separation;Drug user;economic outcome;Economics;Education;Equity;Ethnic Origin;Event;experience;Facilities and Administrative Costs;Fentanyl;Fertility;foster care;Foundations;Future;Geography;grandparent;Growth;Health;Health Policy;Heroin;HIV/AIDS;Homicide;Household;Household and Family;Hypertension;Imprisonment;improved;indexing;insight;intergenerational;labor force participation;Legal;Life;Link;Literature;Love;Low income;manufacture;Marketing;Measures;medication for opioid use disorder;Methods;Modeling;Natural Disasters;Not Hispanic or Latino;novel;Opioid;opioid epidemic;opioid misuse;opioid policy;opioid use;opioid use disorder;Out-Migrations;Outcome;Outcome Study;Overdose;overdose death;Pharmaceutical Preparations;Pneumonia;Police;Policies;Policy Maker;polysubstance use;prescription opioid;Procedures;Public Health;public health emergency;Race;Reporting;Research;Research Personnel;resilience;resilience factor;Resource Allocation;Resources;response;Rural;rural area;social;Social outcome;societal costs;Socioeconomic Status;stem;stressor;Substance Use Disorder;Time;United States;Variant;Widowhood

PROJECT_TITLE: Measuring the Longer Term Social Burdens of the Opioid Crisis on Local Communities


NIH_SPENDING_CATS: Aging;Diabetes;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Diabetes affects over 30 million Americans, which represents a staggering 9.4% of the population. Metformin is an FDA drug commonly used as a ﬁrst line therapy for the treatment of Type 2 Diabetes, which makes up the majority of cases of diabetes in the World. For the first time, this project is directed towards elucidating the molecular targets of Metformin in order to develop novel therapeutics that can better target diabetes – a key disease in the NIDDK and broader NIH portfolio.

PI_NAMEs: REDDY, AKHILESH BASI (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Affect;Aging;American;Binding;Binding Proteins;Biological Assay;Blood Glucose;cardiovascular disorder risk;catalyst;Clinical;Code;Data;Development;Diabetes Mellitus;Disease;Event;experimental study;fly;gain of function;Genes;Glucose;Goals;Health Benefit;healthy aging;Home;Human;Insulin;life span;loss of function;Mammals;Metformin;Mission;model organism;Molecular;Molecular Target;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Organism;Pancreas;Pharmaceutical Preparations;Phylogenetic Analysis;Population;Proteins;Proteomics;Risk Reduction;screening;Testing;Time;Tissues;Transgenic Mice;tumor growth;United States National Institutes of Health;Validation;Yeasts

PROJECT_TITLE: Determination of the mechanistic targets of metformin


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE This work will establish an innovative, broadly applicable paradigm for how tissue regeneration occurs and how neuronal activity affects peripheral tissue regeneration. This work will also discover valuable genes regulating tissue regeneration. The results from our studies lead to innovative strategies for treating tissue repair.

PI_NAMEs: KANG, JUNSU  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Affect;Afferent Neurons;Animal Model;Animals;Behavior;cholinergic neuron;Chromosome Mapping;Defect;Disease;Event;Exhibits;exome sequencing;Genes;genetic analysis;Genetic Models;Genetic Screening;Growth;Impairment;innovation;Ion Channel;Lead;Locomotion;Missense Mutation;Molecular;Molecular Analysis;mutant;Mutation;Natural regeneration;Nerve;nerve supply;Neurons;novel;Pattern;Peripheral;Play;Process;regenerative;Regenerative capacity;Role;SCN8A gene;Sodium Channel;Temperature;tissue regeneration;tissue repair;voltage;Work;Zebrafish

PROJECT_TITLE: Molecular and Genetic Analysis of Fin Regeneration in Zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Telehealth;Women's Health Research

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it seeks to prevent HIV among young African American women in the U.S. South—a population that continues to experience a disproportionate burden of the epidemic. The proposed research aims to test a virtual peer support group accessible via smartphones, with the goal of reducing alcohol misuse and sexual risk and increasing pre-exposure prophylaxis use.

PI_NAMEs: BROWNE, FELICIA AMIRA (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Address;Adoption;Affect;African American;African American population;African American Women;aged;AIDS prevention;alcohol and other drug;Alcohol consumption;alcohol misuse;Alcohols;Area;arm;Asian Women;Behavior Therapy;biobehavior;Biological;Biological Testing;Cellular Phone;Centers for Disease Control and Prevention (U.S.);Classification;Collaborations;Communities;cost;County;Coupled;COVID-19;COVID-19 morbidity;COVID-19 risk;critical period;Data;Data Analytics;Disparity;Drug usage;efficacy evaluation;Enrollment;Epidemic;epidemiologic data;evidence base;Evidence based intervention;experience;Feedback;Focus Groups;Goals;Health;Heavy Drinking;High Risk Woman;HIV;HIV diagnosis;HIV Seronegativity;HIV/AIDS;Human immunodeficiency virus test;Impairment;implementation outcomes;Incidence;Individual;innovation;Intervention;intervention delivery;Interview;Measures;Methods;mHealth;mhealth interventions;Modification;mortality;multi-racial;North Carolina;Outcome;Outcome Assessment;Participant;Patient Self-Report;peer support;Persons;Population;Populations at Risk;pre-exposure prophylaxis;prevent;Prevention;prevention service;Process;Public Health;randomized trial;Reduce health disparities;reduced alcohol use;Research;Research Activity;Research Priority;research study;Resources;response;Risk;Risk Reduction;satisfaction;service providers;sex;sexual risk reduction;Sexually Transmitted Diseases;Social support;Support Groups;Surveys;Tablets;Technology;Testing;Time;United States National Institutes of Health;Unsafe Sex;uptake;Violence;violence prevention;virtual;virtual group;Woman;women's diagnosis;Work;young woman

PROJECT_TITLE: GODDESS (Gathering Online for Dialogue and Discussion to Enhance Social Support): Engaging young African American women in a virtual group app to address alcohol misuse, sexual risk, and PrEP in NC


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Heavy alcohol drinking during adolescence is known to disturb brain development and functioning and increase risk of drinking problems in adulthood, but the extent of the lingering effects of youthful drinking on adult functioning remains unclear. The goal of NCANDA-A (Adulthood) is to determine how adolescent alcohol- related disruption of normal brain growth patterns of brain structure, function, and psychiatric health affects abilities in emerging adulthood. Determining which affected processes remain impaired and which escape alcohol's untoward effects will specify how a youthful-drinking history influences quality of life in adulthood, information obtained only from longitudinal study as proposed by NCANDA-A.

PI_NAMEs: CLARK, DUNCAN B. (contact);LUNA, BEATRIZ

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: 21 year old;Abstinence;Acceleration;Acute;Adolescence;Adolescent;adolescent binge drinking;Adult;Adverse effects;Affect;Affective;Age;Alcohol abuse;Alcohol consumption;alcohol cue;alcohol effect;alcohol expectancy;alcohol use disorder;alcohol use initiation;Alcohols;Behavioral;binge drinking;Biological;Brain;Clinical;Cognition;Cognitive;cognitive control;cognitive performance;cohort;Communities;Computers;COVID-19 impact;COVID-19 pandemic effects;cue reactivity;Data;design;Development;Distress;Dose;drinking;drinking onset;early onset;Economics;Elements;emerging adult;emerging adulthood;Emotional;Event;experience;externalizing behavior;Family;Female;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Goals;gray matter;Growth;Health;heart function;Heart Rate;Heavy Drinking;Home;Impairment;improved;Individual;information processing;Learning;Life;Life Stress;Link;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;male;Measures;Mediating;medical specialties;Memory;Mission;mobile application;Modeling;modifiable risk;Monitor;multimodal neuroimaging;neural;neurodevelopment;neuroimaging;neuropsychiatry;novel;Outcome;Outcome Measure;pandemic disease;Patient Recruitments;Pattern;Personal Satisfaction;Persons;Physical activity;Polysomnography;Positioning Attribute;post-pandemic;pre-pandemic;Process;Protocols documentation;Psychopathology;Psychosocial Factor;Quality of life;Recording of previous events;Recovery;recruit;Research Project Grants;response;Rest;retention rate;Risk;Risk Factors;Sampling;Schools;Sex Differences;Sex Differentiation;Site;Sleep;Sleep disturbances;social;Specific qualifier value;Stress;Structure;Symptoms;System;Technology;Testing;underage drinking;Universities;Work

PROJECT_TITLE: NCANDA Research Project Site: University of Pittsburgh (NCANDA-PITT)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Alcohol Use Disorders (AUDs) are medical conditions in which excessive consumption of alcohol is thought to promote transitions from moderate social drinking to the development of AUDs. It is therefore critical to understand which neuronal circuits and adaptations promote both early alcohol seeking and later excessive alcohol consumption. This application is using advanced technologies to probe specific neuronal pathways in the context of alcohol drinking.

PI_NAMEs: MCELLIGOTT, ZOE ANASTASIA (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Ablation;Acute;alcohol behavior;Alcohol consumption;alcohol exposure;alcohol reward;alcohol seeking behavior;alcohol testing;alcohol use disorder;Alcohols;Amygdaloid structure;Animal Model;anxiety-like behavior;Appetitive Behavior;Behavior;Behavior Therapy;Behavioral;Brain;Caspase;Cell Nucleus;cell type;Cells;Chronic;Consumption;Coupled;Data;Desire for food;Development;Dose;drinking;Electrophysiology (science);Enterobacteria phage P1 Cre recombinase;Ethanol;Exhibits;experience;Functional disorder;gamma-Aminobutyric Acid;Genetic;Heavy Drinking;Human;innovation;knock-down;Lateral;Lesion;Liquid substance;Measures;Medial;Mediating;Medical;neural circuit;neuroadaptation;neuronal circuitry;Neurons;Neuropeptides;Neurotensin;Optics;optogenetics;parabrachial nucleus;Pathologic;Pathway interactions;pharmacologic;Physiological Adaptation;Physiology;Play;Population;Regulation;reinforced behavior;response;Rewards;Rhodopsin;Role;Shapes;Signal Transduction;Signaling Molecule;Slice;small hairpin RNA;social;Stream;Synapses;synaptic function;Technology;Testing;transmission process;vesicular GABA transporter;Viral

PROJECT_TITLE: Probing central amygdala neurotensin neurons in alcohol consumption

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


PI_NAMEs: GRIFFIN, BETH ANN  (contact)

PROJECT_TERMS: Address;Area;Attention;Bayesian Method;Bayesian Modeling;Characteristics;Communication;Communities;Complex;Computer software;COVID-19 pandemic;Data;data resource;data structure;Decision Making;Development;Dimensions;Disparity population;econometrics;Educational workshop;Effectiveness;Equity;Evaluation;Evaluation Studies;experience;Fentanyl;Future;Geographic Locations;Goals;Grant;health inequalities;Health Services Accessibility;Heterogeneity;improved;Individual;infancy;insight;interest;Intervention;Job loss;Literature;Manuscripts;Methodology;Methods;Modeling;novel;Opioid;opioid epidemic;opioid misuse;opioid policy;Outcome;overdose death;Performance;Policies;Policy Analysis;Policy Maker;Policy Research;Population;Practice Guidelines;Public Health;Recommendation;Research;Research Methodology;Research Personnel;Resources;Review Literature;Sample Size;Science;Series;simulation;Social isolation;software development;Statistical Methods;stem;Stress;Subgroup;synergism;Time;tool;Uncertainty;Variant;webinar;Work

PROJECT_TITLE: Optimal Methods for Estimating Policy Effect Heterogeneity in Opioid Policy Research


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative  Exosomes are extracellular vesicles secreted by various types of cells and characterized by unique properties for therapeutic development. Using a multidisciplinary strategy, this application is aimed to develop a novel technology for genetically and chemically reprogramming native exosomes. This innovative class of exosomes with new and/or improved functions and properties are expected to provide important research and therapeutic tools for biomedical applications.

PI_NAMEs: ZHANG, YONG  (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Address;Antibodies;Antigens;Biogenesis;Biological;Biology;Catalytic Domain;CD47 gene;Cell Physiology;cell type;Cells;Characteristics;chemical conjugate;Chemical Engineering;Chemicals;Chimeric Proteins;Circulation;Coupling;Dendritic Cells;design;Development;drug development;Encapsulated;Endosomes;engineered exosomes;Enzyme Inhibitor Drugs;Enzymes;Epidermal Growth Factor Receptor;Exhibits;exosome;extracellular vesicles;functional improvement;Generations;Genetic;Genetic Engineering;Human;immunogenic;immunogenicity;Immunoglobulin Fragments;In Vitro;in vivo;inhibitor;innovation;intercellular communication;interest;Knowledge;knowledge integration;Ligands;Mediating;Membrane;Membrane Fusion;Membrane Proteins;Methods;Modality;Modeling;Monoclonal Antibodies;multidisciplinary;nanocarrier;nanomedicine;nanoparticle;Nature;new technology;next generation;novel;OX40;Pathway interactions;Patients;Phagocytes;photoactivation;Platelet-Derived Growth Factor Receptor;Play;Property;Protein Engineering;Proteins;receptor;Research;Role;Series;Site;Sorting;Specificity;Surface;Synthesis Chemistry;targeted delivery;Technology;technology platform;Therapeutic;Therapeutic Agents;therapeutic development;therapeutic protein;Tissues;TNFSF4 gene;tool;Transmembrane Domain

PROJECT_TITLE: Reprogramming Exosomes for Biomedical Applications

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Similar to electrical circuits, cells possess enzymatic circuits that sense, signal and respond to the presence of redox-active stimuli in their microenvironment. We will design molecular strategies to rewire enzymatic redox circuitry that will enable cells to overcome excess or deficiency of critical redox reagents. These strategies will inform future methodologies for prevention and treatment of several redox-related diseases including cancer, cardiovascular and neurological disorders.

PI_NAMEs: BHAGI, AMBIKA  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acute;Bacteria;Binding;Bioinorganic Chemistry;Biological;Biology;Carbon Monoxide;Cardiovascular Diseases;Cell Physiology;Cells;Chemicals;Chronic;Communication;Degenerative Disorder;design;Disease;DNA;Environment;Enzymatic Biochemistry;Equilibrium;Event;Future;Genus Mycobacterium;Goals;Health;heme a;Heme Iron;Homeostasis;Human;Laboratories;Life;Maintenance;Malignant Neoplasms;Metalloproteins;Metals;Methodology;Molecular;Nervous System Disorder;Nitric Oxide;Oxidation-Reduction;peptidomimetics;Phenotype;Phosphotransferases;Physiological;Physiological Processes;Plants;Prevention;Process;programs;Protein Engineering;Reaction;Reactive Oxygen Species;Reagent;Research;response;Side;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Specificity;Spectrum Analysis;Stimulus;Stress;Structure;System;Work;Zinc

PROJECT_TITLE: Decoding and Rewiring Enzymatic Redox Signal Transduction Pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Services;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Primary Health Care;Rare Diseases;Rehabilitation;Telehealth;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE In this proposal, we are proposing a randomized intervention trial to examine the efficacy of remote genetic services (videoconferencing or phone) as compared to usual care to increase the uptake of genetic testing according to published guidelines in childhood cancer survivors in the North American cohort study, the Childhood Cancer Survivor Study (U24 CA 55727). We plan to evaluate the effectiveness of remote videoconferencing to provide greater knowledge, as well as decrease in distress and depression with genetic services as compared to telephone delivery, as well as the moderators of patient outcomes, and have planned an incremental cost-effectiveness of the three study arms. We expect our findings will provide critical data to provide the basis for further dissemination of these services among cancer survivors and other populations in need of specialized genetic services.

PI_NAMEs: BRADBURY, ANGELA R.;HENDERSON, TARA OLIVE (contact)

PROGRAM_OFFICER_NAME: RANDHAWA, GURVANEET

PROJECT_TERMS: Acute;Address;Adherence;Adult;American;Area;arm;barrier to testing;biomedical referral center;brca gene;cancer diagnosis;cancer genetics;cancer predisposition;Cancer Survivor;cancer therapy;Cancer-Predisposing Gene;Caring;childhood cancer survivor;Childhood Cancer Survivor Study;Clinical;Clinical Trials;cohort;Cohort Studies;Communities;Community Clinical Oncology Program;Community Practice;Consolidated Framework for Implementation Research;Cost Analysis;Counseling;Data;Distress;DNA Sequence Alteration;effectiveness evaluation;effectiveness study;efficacy evaluation;Enrollment;evidence based guidelines;Evidence based practice;Family Cancer History;Future;gaps in access;Genetic;Genetic Carriers;Genetic Counseling;Genetic Models;Genetic Services;genetic testing;Geography;Germ Lines;Germ-Line Mutation;group intervention;Guidelines;Health;Healthcare Systems;high risk;Home;Hybrids;implementation evaluation;implementation study;improved;incremental cost-effectiveness;Individual;Inferior;Inherited;innovation;Intervention;intervention cost;Intervention Trial;Knowledge;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Mental Depression;Methods;Modeling;mutation carrier;National Comprehensive Cancer Network;Outcome;Participant;Pathogenicity;patient population;Patient-Focused Outcomes;Patients;Pediatric Oncology Group;Population;precision medicine;Preventive measure;primary care provider;prophylactic mastectomy;Provider;Publishing;Randomized;Recommendation;remote delivery;Reporting;Risk;Risk Reduction;Sarcoma;Screening for cancer;screening guidelines;Service delivery model;Services;Site;sociodemographics;Specialist;Survivors;System;telegenetics;Telephone;telephone delivery;Testing;three-arm study;TP53 gene;Travel;treatment as usual;uptake;usual care arm;videoconference;Videoconferencing;Woman;Work

PROJECT_TITLE: Improving Delivery of Genetic Services to High Risk Childhood Cancer Survivors: A Randomized Study of Remote Genetic Services Versus Usual Care

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Neurosciences;Nutrition;Obesity;Prevention;Sleep Research

PHR: Sleep duration and quality are related to obesity and cardiovascular diseases. However, how poor sleep influences energy balance (intake vs. expenditure) and whether the causality of the relation exists in the opposite direction (energy balance and cardiometabolic disorders affect sleep) remain unclear. This research program will elucidate the bi-directional relations between sleep, energy balance, and cardiometabolic disorders.

PI_NAMEs: ST-ONGE, MARIE-PIERRE  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acute;Address;adequate sleep;Affect;Awareness;Behavior;blood glucose regulation;Blood Pressure;Body Composition;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Chronic Disease;Circadian desynchrony;circadian pacemaker;Circadian Rhythms;Clinical;Collaborations;Darkness;Eating;energy balance;Energy Intake;Energy Metabolism;Enrollment;equilibration disorder;Etiology;Expenditure;Fatty acid glycerol esters;flexibility;food consumption;Future;Grant;Health;hedonic;immune function;Intake;Intervention;Intervention Studies;Laboratories;Life Style;Light;Measurement;men;Modernization;Neurons;Obesity;obesity risk;Outcome;Pathway interactions;poor sleep;Population;programs;Randomized;Research;Research Personnel;Rewards;Risk Factors;sex;Sleep;Sleep Deprivation;Sleep Disorders;sleep pattern;sleep quality;systemic inflammatory response;Techniques;Testing;Training;Woman

PROJECT_TITLE: Mechanisms addressing the causal relationships of sleep, circadian rhythms, and cardiometabolic health


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Maternal Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: PROJECT NARRATIVE Substance use in pregnant women has increased over the past decade, highlighting the importance of efforts to understand how environmental and other exposures during pregnancy affect brain development and child outcomes. The PRELUDE consortium for the HEALthy Brain and Child Development study will recruit 2720 pregnant women in the 2nd and 3rd trimester and follow their children to age 10, using neuroimaging, behavioral assessments, EEG, biosample collection, and assessments of parent-child interaction and the home environment. This research will lead to greater understanding of factors affecting early childhood brain development, allowing targeted interventions and improved outcomes for mother-child dyads.

PI_NAMEs: ACHESON, ASHLEY ;MCKELVEY, LORRAINE M;OU, XIAWEI  (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: addiction;Address;adverse outcome;Affect;Age;Alcohol consumption;Arkansas;Behavior assessment;Behavioral;Biological;Biological Factors;Birth;Brain;Child;Child Development;Childhood;clinical care;Clinical Research;Cognitive;cohort;Collaborations;Collection;Communities;community engagement;Data;Data Analyses;Data Coordinating Center;data exchange;Dedications;design;Development;early childhood;Electroencephalography;Emotional;Enrollment;Ensure;Environmental Risk Factor;Ethics;Ethnic Origin;evidence base;Exposure to;Family;fetal;Funding;General Population;Genetic;Geography;Goals;Helping to End Addiction Long-term;high risk;high risk infant;high risk population;Home environment;Image;improved;improved outcome;Infant;insight;Institution;Intervention;Legal;Longitudinal Studies;Magnetic Resonance Imaging;Maternal and Child Health;Maternal Health;maternal outcome;maternal stress;Measures;Medical center;Mental Health;Mothers;neurodevelopment;neuroimaging;neurophysiology;North Carolina;nutrition;Opiate Addiction;Opioid;opioid misuse;Outcome;Parent-Child Relations;Parents;Participant;Pediatric Hospitals;Phase;Physiological;post pregnancy;Poverty;Pregnancy;Pregnant Women;prenatal;Prenatal care;prenatal experience;prenatal exposure;Protocols documentation;Public Health;Questionnaires;Race;recruit;Research;Research Institute;resilience;Resources;Risk;Risk Factors;risk minimization;Sample Size;Sampling;School-Age Population;Second Pregnancy Trimester;Series;Site;social;socioeconomic diversity;Speed;stem;substance use;Third Pregnancy Trimester;Tobacco;Toxic Environmental Substances;United States National Institutes of Health;Universities;Visit;wearable device;Work

PROJECT_TITLE: 1/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Pancreatic cancer is one of the deadliest cancers and effective therapies are lacking. We have discovered a new class of small molecule drug that targets pancreatic cancer and also enhances the effects of FDA- approved HDAC inhibitors. We anticipate that these studies will reveal new ways of treating pancreatic cancer in preclinical models of cancer, setting the stage for clinical development and the delivery of a new treatment regimen to patients in need.

PI_NAMEs: DOLLOFF, NATHAN G. (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: activating transcription factor 3;Address;Affinity;analog;anticancer activity;Antineoplastic Agents;Antitumor Response;Apoptotic;Automobile Driving;Binding;Biochemical;Biological Assay;cancer cell;cancer clinical trial;Cancer Model;cancer therapy;cancer type;CASP3 gene;Cell model;Cellular Assay;Chemicals;Chemosensitization;ChIP-seq;chromatin immunoprecipitation;Chromatin Structure;Clinic;clinical development;Clinical Trials;Combined Modality Therapy;comparative;Coupled;Coupling;Data;Development;Diagnosis;Docking;drug candidate;Drug Combinations;drug structure;Drug Targeting;effective therapy;endoplasmic reticulum stress;epigenetic drug;Epigenetic Process;Evaluation;Exhibits;expectation;experimental study;Family member;FDA approved;Future;Genes;Genetic Transcription;Genetically Engineered Mouse;Goals;Hematologic Neoplasms;Heme;Histologic;Histone Acetylation;Histone Deacetylase Inhibitor;In Vitro;in vivo;Indenes;inhibitor;inhibitor therapy;innovation;insight;knock-down;Knowledge;KRASG12D;Lead;Literature;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;Metabolic;Modeling;Molecular;mouse model;nanomolar;new combination therapies;novel;novel drug class;novel therapeutic intervention;novel therapeutics;Oncology;overexpression;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Play;pre-clinical;Pre-Clinical Model;programs;promoter;Protein Biosynthesis;Protein Disulfide Isomerase;protein folding;proteostasis;Research;Resistance;response biomarker;RNA Binding;RNA Polymerase II;Role;Signal Transduction;simulation;Site;Site-Directed Mutagenesis;small molecule;Solid;Specificity;Structure;Survival Rate;synergism;Therapeutic;therapeutic evaluation;transcriptome sequencing;Translating;Treatment Protocols;tumor;Work;X-Ray Crystallography

PROJECT_TITLE: Inhibitors of Oxidative Protein Folding For The Treatment of Cancer

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: PARIS

ORG_COUNTRY: FRANCE

ORG_FIPS: FR

ORG_NAME: INSTITUT PASTEUR

PHR: Project Narrative In recent years, there have been several outbreaks, such as Ebola and Zika, that have struck the world. We will set up research infrastructure and pipeline in countries where further outbreaks are likely to occur to study how viruses from animals and/or insects could adapt themselves to infect humans and cause outbreaks. The study will help us to better prepare to prevent and to react faster and more efficiently to the future outbreaks.

PI_NAMEs: SAKUNTABHAI, ANAVAJ  (contact);SIMON-LORIERE, ETIENNE

PROGRAM_OFFICER_NAME: WOODSON, SARA ELAINE

PROJECT_TERMS: adaptive immune response;Africa;analysis pipeline;Animals;Antibodies;Antibody Repertoire;Area;Arthropods;behavioral study;Biological;Cambodia;CD4 Positive T Lymphocytes;Cells;Cellular Immunity;Central Africa;Cloud Computing;Collection;Communicable Diseases;Computer Systems;Country;Crimean-Congo Hemorrhagic Fever Virus;Data Analyses;data sharing;Dengue Virus;design;detection method;Diagnosis;Diagnostic Reagent;diagnostic tool;Disease;Disease Outbreaks;Ebola;efficacy study;Emerging Communicable Diseases;emerging pathogen;Encephalitis;Endemic Diseases;Environment;Epidemic;epidemic potential;Epidemiologist;Flavivirus;future outbreak;Genome;Goals;Health;Healthcare;Healthcare Systems;high risk;Human;human monoclonal antibodies;Immune response;Immunologic Receptors;immunopathology;improved;Infection;Infectious Diseases Research;Infrastructure;Insect Vectors;Insecta;insight;Knowledge;Laboratories;metagenomic sequencing;Molecular;Monoclonal Antibodies;multiplex assay;Mutation;novel;novel diagnostics;outbreak concern;outbreak preparedness;Outcome;pandemic potential;pathogen;Pathogenesis;Pharmaceutical Preparations;Phylogenetic Analysis;Population;Prevalence;Prevalence Study;prevent;Reaction;Reagent;repository;Research Infrastructure;response;reverse genetics;Rift Valley fever virus;Risk;Risk Factors;RNA Viruses;Role;Sampling;Senegal;Serology;Seroprevalences;serosurvey;single-cell RNA sequencing;Site;Solar Energy;Southeastern Asia;Structure;Surveys;System;Technology;tool;transcriptomics;transmission process;vaccine development;Variant;vector;vector competence;Viral;Viral Antibodies;Viral Hemorrhagic Fevers;Viral Pathogenesis;virome;Virus;Virus Diseases;ZIKA

PROJECT_TITLE: Inter-regional study of transmission, adaptation and pathogenesis of viruses with pandemic potential in Southeast Asia and West/Central Africa


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;HIV/AIDS;Human Genome;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Infection with Human Immunodeficiency Virus (HIV) is incurable, despite the existence of antiretroviral therapy (ART) that effectively targets the viral life cycle. The lack of a cure for HIV infection has been linked to a small population of replication-competent HIV proviruses (denominated the latent HIV reservoir), which persists during ART even when viremia is undetectable, and is invariably associated with virus rebound when ART is stopped. This proposal uses a novel microfluidics-based multi-omics approach (RNA-seq, ATAC-seq, Ab-seq) to define the genomic mechanisms that control the HIV reservoir, with the goal of developing new therapeutics and biomarkers for people living with HIV.

PI_NAMEs: ABATE, ADAM R.;QUINTANA, FRANCISCO J. (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Address;Antibodies;antiretroviral therapy;ATAC-seq;Bar Codes;Biological Markers;Biology;Blood;Catalogs;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Separation;Cells;Chromatin;Custom;Data;Defective Viruses;Detection;Development;digital;Dissection;DNA;Epigenetic Process;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genome;genome-wide analysis;Genomic DNA;Genomics;Goals;high throughput analysis;HIV;HIV Genome;HIV Infections;HIV Seropositivity;immunoregulation;In Vitro;Individual;Infection;integration site;interest;Investigation;latent HIV reservoir;Length;Life Cycle Stages;Link;Membrane Proteins;Messenger RNA;Methods;Microfluidics;Monitor;multiple omics;Natural Killer Cells;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Pathway interactions;Persons;Physiological;Population;Process;programs;Property;Proteins;Proteome;proteomic signature;Proteomics;Proviruses;Regulation;Research;Role;Sampling;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Site;Sorting;Surface;System;T-Lymphocyte;Testing;Therapeutic;Time;tool;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Transposase;Viral;Viral Markers;viral rebound;Viremia;Virus;Virus Latency

PROJECT_TITLE: Multi-omic dissection of the transcriptional, epigenetic, and proteomic signatures of cells infected with latent HIV


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Contraception/Reproduction;Endocrine Disruptors;Estrogen;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Obesity;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) is the leading cause of death among women in the U.S. and has one of the costliest economic burdens. We propose to determine whether exposure to legacy per- and polyfluoroalkyl substances and their replacements alter CVD risk in women across their reproductive lives. If successful, our study will advance knowledge of CVD etiology as it relates to pregnancy and midlife environmental exposures.

PI_NAMEs: JAMES-TODD, TAMARRA M (contact);ZOTA, AMI R

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Age;Blood Pressure;Body mass index;Body Weight Changes;Breast Feeding;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Central obesity;Chemical Exposure;Chemicals;Clinical;cohort;Data;data access;Development;Diastolic blood pressure;disorder risk;Dyslipidemias;Economic Burden;Endocrine Disruptors;Environment;environmental chemical;Environmental Exposure;Environmental Impact;Environmental Pollutants;Environmental Risk Factor;Etiology;Evaluation;Exposure to;Fasting;fasting glucose;First Pregnancy Trimester;follow-up;Follow-Up Studies;Future;Genetic;Glucose;Glycosylated hemoglobin A;Health Expenditures;high body mass index;Hour;Hyperglycemia;Hypertension;indexing;Individual;innovation;Insulin;Knowledge;late life;Life Cycle Stages;Life Style;Lipids;Longitudinal cohort study;Measures;Menopausal Status;middle age;modifiable risk;Modification;Mothers;next generation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;OGTT;Outcome;Participant;Phase;Plasma;Poly-fluoroalkyl substances;Population;post pregnancy;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnancy hypertension;Pregnancy Trimesters;pregnant;Pregnant Women;Production;Prospective, cohort study;reproductive;reproductive outcome;Research;Research Design;Risk;Risk Factors;Risk Reduction;Signal Transduction;Stress Tests;Techniques;Testing;Time;United States;Weight Gain;Woman;Women's mortality

PROJECT_TITLE: Per- and Polyfluoroalkyl substances mixtures and maternal cardiovascular disease risk across the reproductive life course

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: Flagstaff

ORG_NAME: ANEUVAS TECHNOLOGIES, INC.

ORG_STATE: AZ

PHR: Narrative Of the nearly 800,000 Americans who have a stroke per year, 87% experience ischemic stroke.1 This project will assess the safety and efficacy of the aspiration catheter with a patient-adaptable radially expandable tip, which may improve clinical outcomes of large vessel occlusion (LVO) and medium vessel occlusion (MeVO) treatment due to improved access, navigation, and clot digestion.7 These studies will provide the basis for improved mechanical thrombectomy techniques and technology for the treatment of LVO and MeVO ischemic stroke.

PI_NAMEs: BECKER, TIM  (contact)

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Address;American;Arizona;aspirate;biomaterial compatibility;Biomedical Engineering;brain tissue;Caring;Catheters;Circle of Willis;Clinical;clinically relevant;Coagulation Process;cost;design;Development;Devices;Diameter;Digestion;disabled;Disabled Persons;Distal;efficacy evaluation;efficacy testing;Eligibility Determination;Excision;experience;Future;Goals;Human;Improve Access;improved;In Vitro;in vitro Model;in vivo Model;Individual;Injury;innovation;Ischemia;Ischemic Stroke;Laboratories;Long term disability;manufacture;Measures;Mechanics;Medical;meetings;migration;Modeling;Monitor;novel;Outcome;Patient-Focused Outcomes;Patients;Performance;Phase;Press Releases;pressure;prevent;Property;prototype;Quality of life;Radial;Recovery of Function;research clinical testing;Resources;Retrieval;revascularization;Safety;safety assessment;safety testing;Small Business Technology Transfer Research;standard of care;Stents;Stroke;stroke patient;stroke therapy;success;System;Systems Development;Technology;technology/technique;Testing;Thrombectomy;Thrombus;Time;United States;Universities;Work

PROJECT_TITLE: Developing a new aspiration catheter solution for the treatment of large and medium vessel occlusions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-W(12)B]