NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Women's Health Research

ORG_CITY: Columbus

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Triple-negative breast cancers (TNBCs) are highly aggressive, metastatic and recurrent. The standard chemotherapies and radiotherapies have marginal curative benefits but there is no efficacious targeted therapy. This project will develop and fully evaluate a new strategy, i.e. the combined dual-targeted mitochondrial luminoptogenetic gene therapy and synthetic lethality of poly (ADP-Ribose) polymerase inhibitor, to eliminate the metastatic and heterogeneous TNBCs.

PI_NAMEs: LIU, XIAOGUANG MARGARET (contact);YANG, EDDY SHIH HSIN;ZHOU, LUFANG

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: 4T1;Achievement;Aftercare;Anthracycline;anti-cancer;Apoptosis;Biodistribution;Bioluminescence;Biomanufacturing;Bioreactors;brca gene;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Breast Cancer Treatment;Bypass;cancer cell;cancer drug resistance;cancer subtypes;CD276 gene;Cell Death;Cell Physiology;Cells;chemotherapy;Chemotherapy and/or radiation;Clinic;Clinical Trials;Cytoplasm;Cytosol;cytotoxic CD8 T cells;Cytotoxic Chemotherapy;deep ocean;delivery vehicle;Dependovirus;Distant;DNA Damage;DNA Repair;DNA Repair Disorder;DNA Repair Inhibition;dosage;Drug resistance;drug resistance development;Elements;Engineering;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Evaluation;exosome;Flow Cytometry;Gene Expression;gene therapy;Genes;Heterogeneity;Histology;Histopathology;Human;Immune;immune function;Immunity;Immunocompetent;Immunohistochemistry;immunoregulation;Impairment;improved;in vivo;Infiltration;inhibitor;Injections;Inner mitochondrial membrane;innovation;Investigation;lapatinib;Life;light gated;Literature;Luciferases;luciferin;Macrophage;Malignant Neoplasms;Mediating;Membrane;Membrane Potentials;Metastatic/Recurrent;Microarray Analysis;Mitochondria;Modeling;Monoclonal Antibodies;nanoluciferase;Neoplasm Metastasis;novel strategies;Oncology;Organ;overexpression;PARP inhibition;Pathology;patient derived xenograft model;patient response;Patients;Play;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;Pre-Clinical Model;prevent;promoter;Proteins;Proteomics;Quality of life;Recurrence;Relapse;repaired;Research;response;Role;Shrimp;Signal Transduction;Signal Transduction Pathway;Specificity;Survival Rate;synergism;systemic toxicity;targeted delivery;targeted treatment;taxane;Technology;Testing;Tissue Microarray;Tissues;Toxic effect;Toxicology;Transcript;transduction efficiency;Translations;Transplantation;Treatment Efficacy;Treatment Protocols;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Burden;Tumor Immunity;tumor microenvironment;Tumor Volume;ultrasound;Western Blotting;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Combine mitochondrial gene therapy and synthetic lethal chemotherapy to treat triple-negative breast cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: LM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;HIV/AIDS;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Our proposal for training in biomedical informatics and data science at Stanford harnesses the opportunity to produce the next generation of researchers who will enable precision medicine through innovations in translational bioinformatics, health care informatics and clinical research informatics. We have a 39-year track record of producing bioinformatics leaders who pursue research-driven careers in academia and industry. We remain well-positioned to advance human health through future training in biomedical informatics and data science.

PI_NAMEs: PLEVRITIS, SYLVIA KATINA (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Artificial Intelligence;Bioinformatics;Biological Sciences;biomedical data science;biomedical informatics;clinical care;Clinical Research;Clinical Sciences;Companions;computer science;Course Content;Data;Data Science;design;digital health;Doctor of Philosophy;Education;Educational Curriculum;empowerment;Engineering;Environment;equity, diversity, and inclusion;Explosion;Future;Grant;Health;Healthcare;HIV;Human;Image;improved;Informatics;informatics training;innovation;Instruction;Mathematics;Medicine;Mentors;next generation;outreach;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;precision medicine;programs;recruit;Reproducibility;Research;Research Methodology;Research Personnel;responsible research conduct;Schools;statistics;Training;Training Programs;Training Support;Universities

PROJECT_TITLE: Biomedical Informatics Training Program at Stanford


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Patient Safety

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative Cancer research is dependent on the availability of high quality biospecimens linked to patient information from clinical trials. The SWOG Biospecimen Bank collects, processes, banks and distributes biospecimens from adult cancer patients enrolled on NCI-sponsored clinical trials. These biospecimens are eventually used by researchers to study different types of cancer. The results of this research benefits patients through discovery of targeted therapy and/or improved outcomes and survival with the ultimate goal of cancer prevention and cure.

PI_NAMEs: RAE, JAMES MICHAEL;RAMIREZ MILAN, NILSA DEL CARMEN (contact)

PROGRAM_OFFICER_NAME: MAKHLOUF, HALA

PROJECT_TERMS: Address;Adult;anti-cancer research;biobank;Biological Specimen Banks;Breast;cancer clinical trial;Cancer Patient;cancer prevention;cancer type;Clinical;Clinical Data;Clinical Medicine;Clinical Research;Clinical Treatment;clinical trial protocol;Clinical Trials;Clinical Trials Information for Patients;Collaborations;Collection;Colon;Component of the National Cancer Institute;Coupled;Data;Data Coordinating Center;data management;Data Reporting;data sharing;design;Diagnostic;Disease;Ensure;Epidemiology;experience;follow-up;Goals;Guidelines;Health protection;Human;Immunologic Monitoring;improved;improved outcome;innovative technologies;Laboratories;laboratory equipment;leukemia;Link;Lung;Lymphoma;Malignant Neoplasms;Marketing;Melanoma;Molecular Biology;Molecular Profiling;Multiple Myeloma;National Cancer Institute;National Clinical Trials Network;operation;Operative Surgical Procedures;participant enrollment;Pathologic;Patients;Pediatric Hospitals;Policies;Procedures;Process;programs;Prostate;Protocols documentation;Qualifying;Quality Control;Reporting;Research;Research Institute;Research Personnel;Residual state;Resources;Sampling;Services;Site;Southwest Oncology Group;System;targeted treatment;Technology;Therapeutic;therapy outcome;translational medicine;Translational Research;Treatment Protocols;tumor;Work

PROJECT_TITLE: SWOG Biospecimen Bank to Support NCI NCTN


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE We propose to combine an innovative machine learning algorithm with synthetic biology approaches to design new proteins that can read and write information from and into cells in vivo and consequently, to improve communication with synthetic biological circuits that precisely control diagnostic and therapeutic agents. Such technology is likely to move the needle towards the next generation of treatment strategies for devastating diseases which currently have a profound negative impact on public health.

PI_NAMEs: BANZHAF, WOLFGANG ;GILAD, ASSAF A (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Algorithmic Software;Algorithms;Artificial Intelligence;Back;Bacteria;Binding;Binding Proteins;Biochemistry;Biocompatible Materials;Biological;Biomedical Engineering;Cells;Chemicals;Clinical Treatment;clinically relevant;Collaborations;Communication;Complex;Computer Models;computer science;computerized tools;Data;Data Set;design;Diagnosis;Diagnostic;Directed Molecular Evolution;Discipline;Disease;Drug Delivery Systems;Engineering;Evolution;experience;extracellular vesicles;feeding;Foundations;functional improvement;Gadolinium;Gene Delivery;Genes;Genetic;Genetic Programming;Human;imaging agent;imaging probe;improved;in vitro testing;in vivo;in vivo Model;innovation;Knowledge;Lanthanoid Series Elements;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Mammalian Cell;Measurement;Medicine;metabolic engineering;Metals;Methods;Modeling;Molecular Genetics;Neck;Needles;new technology;next generation;non-invasive imaging;novel;novel diagnostics;novel therapeutic intervention;Output;Patients;peptide drug;Peptides;Personal Satisfaction;Pharmaceutical Preparations;Pharmacology;Precision therapeutics;protein aminoacid sequence;protein complex;Protein Engineering;protein function;Proteins;Protons;Public Health;Reading;Relaxation;Reporter;Reporter Genes;Reporting;Signal Transduction;Specificity;synthetic biology;synthetic peptide;synthetic protein;System;Technology;Testing;Therapeutic;Therapeutic Agents;Time;tool;training data;Translating;treatment strategy;triple-negative invasive breast carcinoma;Whole Organism;Writing

PROJECT_TITLE: Evolution and optimization of synthetic <READ/WRITE> function from and into cells using genetic programming

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The area of developmental neuroscience and psychopathology has already demonstrated great potential to inform the understanding of the causal pathways and mechanisms of mental illness. This training grant renewal seeks to continue to develop new research scientists in this area, building on the track record of success over the last two cycles. The division of Child Psychiatry at Washington University School of Medicine is well poised to continue and expand this unique post-doctoral training program based on established expertise in a range of child neuroimaging modalities, genetics, gut microbiome, and sleep/circadian rhythms offered by the multidisciplinary mentoring group. The program is directed by two researchers with complimentary expertise in developmental psychopathology (Dr. Joan Luby) and clinical neuroscience and neuroimaging (Dr. Deanna Barch) who have successfully collaborated on the first two cycles of funding, launching numerous young scientists in this domain.

PI_NAMEs: BARCH, DEANNA ;LUBY, JOAN L. (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TITLE: Developmental Neuroscience and Child Psychopathology


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: RENO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: PROJECT NARRATIVE Several G-protein-coupled receptors use the common diffusible second messenger, cAMP, in the same cell, and yet elicit vastly different functional responses. The prerequisite for achieving such divergent functions is believed to be due to segregation of cAMP into separate compartments such that the cAMP can only access a select subset of target proteins that are involved in mediating the responses specific to the stimulated receptor. The main objective of this proposal is to unravel the role of confined spaces associated with mitochondria in mediating compartmentation of cAMP, with the ultimate goal of providing a therapeutic strategy for managing cardiovascular diseases linked to dysregulation of cAMP compartmentalization, including cardiac arrhythmias, hypertrophy, and heart failure.

PI_NAMEs: AGARWAL, SHAILESH  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: A kinase anchoring protein;Adopted;Adult;Affect;Anatomy;Arrhythmia;beta-adrenergic receptor;Biosensor;Buffers;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cell Volumes;Cells;Computer Models;computer studies;Computing Methodologies;Confined Spaces;Confocal Microscopy;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytoskeletal Proteins;Development;Diffusion;Disease;disease model;Electrophysiology (science);enzyme activity;Enzymes;Event;Excision;Fluorescence Resonance Energy Transfer;G-Protein-Coupled Receptors;glucose-regulated proteins;Goals;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Human;Hypertrophy;Image;Impairment;Individual;knock-down;Link;Location;mathematical model;Mathematics;Measures;Mediating;Membrane;Membrane Microdomains;Mitochondria;Modeling;Movement;Muscle Cells;muscle LIM protein;Myofibrils;nanoscale;novel therapeutic intervention;Obstruction;Organelles;Outcome;patch clamp;phosphoric diester hydrolase;Play;Positioning Attribute;prevent;Process;Production;Prostaglandin Receptor;protein expression;Proteins;Rattus;receptor;Regulation;response;restraint;Role;Sarcoplasmic Reticulum;Second Messenger Systems;segregation;Signal Transduction;small hairpin RNA;Spectrum Analysis;Structure;Study models;Subcellular Spaces;Techniques;Testing;Therapeutic;Ventricular

PROJECT_TITLE: Regulation of compartmentalized cAMP signaling by mitochondria-associated spaces in adult ventricular myocytes

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Telehealth

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Young adults in the U.S. (ages 18-24) have the highest and fastest growing rates of suicidal thoughts and behaviors, but the lowest rates of mental health care. This project aims to design and pilot an automated interactive safety planning service delivered via SMS that yields highly personalized safety plans and supports use over time. By accomplishing the proposed training goals and research project, this project will generate data to support an efficacy trial.

PI_NAMEs: MEYERHOFF, JONAH  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Acceleration;Address;Adherence;Adult;advocacy organizations;Age;age group;Aptitude;Attitude;automated text message;Award;career;Caring;Cessation of life;Clinical;Collaborations;Communication;Communication Tools;community setting;control trial;coping;Data;design;Development;digital;digital mental health;digital technology;Documentation;Educational workshop;Effectiveness;efficacy testing;efficacy trial;Ensure;evidence base;experience;Face;feasibility trial;Feedback;Feeling hopeless;Feeling suicidal;follow-up;Frequencies;Goals;Health;implementation science;Individual;Infrastructure;interest;Intervention;intervention effect;iterative design;Knowledge;Life;Light;Lived experience;Maintenance;Measures;Mental Depression;Mental Health;Mental Health Services;Methods;mHealth;Monitor;National Institute of Mental Health;online community;Outcome;Pain;Pathway interactions;Patients;Pattern;Persons;Population;Populations at Risk;preference;Preventive care;preventive intervention;primary outcome;Privatization;Process;process optimization;programs;Randomized, Controlled Trials;recruit;reducing suicide;Reporting;Research;Research Activity;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Risk;Running;Safety;Scientist;screening;secondary outcome;Self Direction;Self Management;Services;suicidal;suicidal behavior;suicidal individual;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surveys;Symptoms;Technology;Telephone;Testing;Text Messaging;therapeutic target;therapy design;Time;tool;Touch sensation;Training;Training Activity;Translating;treatment effect;trial design;usability;user centered design;Waiting Lists;web site;young adult

PROJECT_TITLE: mHealth for suicide prevention: Design, development, and feasibility of a scalable SMS-based safety planning intervention

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: NARRATIVE – OVERALL Sanford Burnham Prebys Medical Discovery Institute (SBP) is an independent nonprofit research and graduate degree-granting institution located in La Jolla, CA, that conducts laboratory-based biomedical research. The SBP Cancer Center's vision is to make paradigm-shifting discoveries that will underlie novel therapeutic modalities by creating, translating, and disseminating exceptional cancer basic science. This will be achieved by conducting cutting-edge, multidisciplinary basic research, advancing our discoveries into early pre-clinical development, and educating and training the next generation of cancer scientists.

PI_NAMEs: COMMISSO, COSIMO  (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Applications Grants;Area;Basic Science;Biological Sciences;Biomedical Research;Biotechnology;Cancer Center;Cancer Center Support Grant;Cancer Patient;Cancer Science;cancer therapy;Cessation of life;Collaborations;County;Development;Diagnosis;drug discovery;Evaluation;experience;Faculty;Funding;Gene Targeting;Goals;Graduate Degree;Grant;Human;Institution;International;Investments;Laboratories;Maintenance;Malignant Neoplasms;Medical;member;Mission;Modality;multidisciplinary;NCI-Designated Cancer Center;next generation;novel;novel therapeutics;Organizational Change;Pilot Projects;pre-clinical;preclinical development;Prevention;Private Sector;programs;recruit;Research;Research Personnel;Resource Sharing;Resources;Scientist;Signal Transduction;skills;small molecule;Strategic Planning;therapeutic development;Training;Translating;translational cancer research;treatment center;tumor immunology;tumor initiation;tumor metabolism;tumor microenvironment;United States National Institutes of Health;Vision;working group

PROJECT_TITLE: Cancer Center Support Grant (CCSG)


NIH_SPENDING_CATS: Cancer

PI_NAMEs: RONAI, ZEEV A. (contact)

PROJECT_TERMS: Cancer Center;Cancer Center Support Grant;Communication;Crowns;Doctor of Philosophy;Ensure;Equipment;Evaluation;Event;Faculty Recruitment;Grant;Leadership;Medical;operation;outreach;Pilot Projects;Play;prevent;Process;Resource Sharing;Resources;Role;Strategic Planning;Structure;Work

PROJECT_TITLE: Admin Core


PROJECT_TERMS: Academia;Accreditation;Advocate;anti-cancer research;Area;Basic Cancer Research;Basic Science;Biotechnology;Cancer Center;Cancer Center Support Grant;Cancer Patient;cancer therapy;career;Clinical;community advisory board;Community Health Education;Dedications;Disadvantaged;Disease;Education;Education and Outreach;Employment;Event;experience;Faculty;Feedback;Goals;graduate student;high school;High School Student;Human;Institution;Malignant Neoplasms;Medical;Mentors;Minority;multidisciplinary;NCI Center for Cancer Research;novel therapeutics;outreach;outreach program;Postdoctoral Fellow;Preparation;Prevention;programs;Research Personnel;Research Project Grants;Scientist;Survivors;Training;Training and Education;training opportunity;undergraduate student;university student;Visit;Work

PROJECT_TITLE: Cancer Research Career Enhancement and Related Activities (CRCERA)


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative The proposed research Program is relevant to public health because we are addressing a major gap in the field of cancer research by seeking to prioritize and catalyze the pace of new therapy development for children, adolescents and adults with neuroblastoma. Within the context of the National Cancer Institute’s Pediatric In Vivo Testing Program, the proposed research Program is highly relevant to the NIH mission of developing rational evidence-based strategies to reduce the health burden of neuroblastoma and other cancers.

PI_NAMEs: MOSSE, YAEL P (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Adolescent;Adrenocortical Carcinoma;Adult;Allografting;anti-cancer research;Antineoplastic Agents;Biological Assay;Biological Markers;biomarker driven;Caring;Cause of Death;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Child;Child Development;Childhood;Clinic;Clinical;clinical development;Clinical Trials;Clinical Trials Design;Collaborations;Collection;Communities;companion diagnostics;Coupled;Data;Dedications;design;Development;Diagnosis;Disease;disease model;disorder risk;Drug Targeting;drug testing;early phase clinical trial;evidence base;Foundations;Funding;Genetic Fingerprintings;Genetic Predisposition to Disease;Genomics;Glioma;Goals;Health;high risk;human model;Immunooncology;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;In Vitro;in vivo evaluation;individualized medicine;Industry;infancy;Inflammatory Pseudotumor;Infrastructure;innovation;Ki-1 Large-Cell Lymphoma;Knowledge;Leadership;Malignant Childhood Neoplasm;Malignant Neoplasms;Measurable;Melanoma;Mission;Modeling;Modernization;Molecular;Morbidity - disease rate;mouse model;Mus;MYCN gene;National Cancer Institute;Neoplasm Metastasis;Neuroblastoma;next generation sequencing;novel;novel therapeutics;Oncogenic;patient biomarkers;patient derived xenograft model;Patient Monitoring;Patient Selection;Patients;Pediatric Oncology;Pharmaceutical Preparations;Pharmacology;Phase;Play;Positioning Attribute;pre-clinical;Pre-Clinical Model;Preclinical Testing;preclinical trial;programs;Public Health;public-private partnership;Qualifying;Race;Radiation therapy;rare condition;rational design;Reagent;Recurrent disease;refractory cancer;Relapse;Research;Resource Sharing;Resources;response;Role;Sampling;screening;Series;Solid;Solid Neoplasm;Survivors;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Trials;therapy design;tool;Toxic effect;Translating;translational research program;Treatment Failure;tumor;United States National Institutes of Health;Work

PROJECT_TITLE: NCI Pediatric In Vivo Testing Program: Neuroblastoma


PI_NAMEs: SACCO, ALESSANDRA  (contact)

PROJECT_TERMS: Acceleration;Accreditation;animal care;animal facility;Animal Model;animal resource;Animals;Behavioral;Blood;Blood Cells;Body Weight;Breeding;Cancer Center;Cancer Center Support Grant;Caring;Censuses;Collaborations;Communication;Computer software;Contract Services;Core Facility;cost effective;cost effectiveness;Data Analyses;Development;Doctor of Philosophy;efficacy study;Employee;Equipment;Experimental Designs;Faculty;Fatty acid glycerol esters;Feedback;Fluorescence;genetic pedigree;Genetic study;Grant;Growth;Growth and Development function;House mice;Housing;IACUC;imaging modality;Imaging technology;in vivo;in vivo imaging;Individual;Injections;Institution;Intramuscular;intraperitoneal;Intravenous;Investigation;irradiation;Lead;Leadership;luminescence;Magnetic Resonance Imaging;Maintenance;Malignant Neoplasms;mammary;Measurement;meetings;member;Metabolic;Modeling;Mus;Neoplasm Metastasis;Operative Surgical Procedures;Oral;Paper;patient derived xenograft model;Perfusion;Positron-Emission Tomography;Postoperative Period;Procedures;programs;Protocols documentation;Publications;Rattus;repaired;Research;Research Personnel;Resource Sharing;Resources;Roentgen Rays;Sampling;Sanitation;Science;Scientist;Serum;Service animal;Services;single photon emission computed tomography;square foot;Sterilization;Stress;subcutaneous;Surveys;System;Tail;Techniques;Technology;Testing;Time;Tissue Banks;Training;Training Technics;tumor;tumor growth;tumor progression;ultrasound;Veins;ventilation;Weaning;Work;Xenograft Model

PROJECT_TITLE: Animal Resources


NIH_SPENDING_CATS: Bioengineering;Cancer;Networking and Information Technology R&D (NITRD)

PI_NAMEs: EMERLING, BROOKE M (contact)

PROJECT_TERMS: Acceleration;AGTR2 gene;Algorithmic Analysis;Calendar;Cancer Center;Cancer Center Support Grant;Cells;cellular imaging;Communication;Computer software;Computer Workstations;Contract Services;Core Facility;cost effectiveness;Cryoultramicrotomy;Data;Data Analyses;Doctor of Philosophy;Documentation;Employee;Equipment;Experimental Designs;Faculty;Feedback;Fluorescence;fluorescence microscope;Fluorescence Resonance Energy Transfer;Grant;Histologic;Histology;human tissue;Hybrids;Image;Image Analysis;imaging facilities;Imaging technology;Immunofluorescence Immunologic;Immunohistochemistry;In Situ Hybridization;Institution;Institutional Review Boards;instrument;instrumentation;intravital microscopy;Label;Laboratories;Lasers;Leadership;Light;live cell imaging;Maintenance;Malignant Neoplasms;meetings;member;Microscope;Microscopy;Mission;multi-photon;Pathology;Preparation;programs;Publications;reconstruction;repaired;Research;Research Personnel;Reservations;Resolution;Resource Sharing;Scanning;Science;Scientist;Services;Slide;Stains;superresolution microscopy;Surveys;System;Technology;Tissues;Training;Transcript;ultra high resolution;Work

PROJECT_TITLE: Cell Imaging and Histology


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative The project aims to develop materials, technology, tools and processes for manufacturing quantitative anthropomorphic MRI phantoms that mimic multiple quantitative MRI parameters. This will be the first time that such a comprehensive set of MRI parameters is produced in a tissue-mimicking phantom. The project will greatly facilitate the development and clinical translation of quantitative MRI.

PI_NAMEs: ARIAS, ANA CLAUDIA;LUSTIG, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TITLE: Multi-parametric anthropomorphic MRI Phantoms technology for reliable and reproducible structural and quantitative MRI

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PI_NAMEs: ZHAO, JIANHUA  (contact)

PROJECT_TERMS: Acceleration;Area;Biological;biological systems;Biology;biophysical analysis;Cancer Center;Cancer Center Support Grant;Chemistry;Collaborations;Communication;Complex;Computer software;Contract Services;Core Facility;cost effectiveness;Cryoelectron Microscopy;Crystallization;Data Analyses;Detection;detector;Devices;Doctor of Philosophy;Electrons;Employee;Equipment;Experimental Designs;Faculty;Feedback;Fluorescence;Goals;Grant;Image;Incubators;Individual;Infrastructure;Institution;instrument;instrumentation;interdisciplinary approach;Interferometry;Laboratories;Leadership;Length;Ligands;Maintenance;Malignant Neoplasms;meetings;member;Mission;Molecular;Nuclear Magnetic Resonance;operation;Optics;Phase;programs;Protein Analysis;protein function;protein protein interaction;protein structure;Proteins;Publications;repaired;Research;Resource Sharing;Resources;Robotics;Roentgen Rays;Science;Scientist;Services;solid state;solid state nuclear magnetic resonance;Spectrometry;Spectrophotometry;structural biology;Structure;Surface Plasmon Resonance;Surveys;Technology;Time;Titan;tomography;Training;Visualization;Work;X ray diffraction analysis;X-Ray Crystallography

PROJECT_TITLE: Structural Biology


PROJECT_TERMS: Acceleration;Antibodies;Cancer Center;Cancer Center Support Grant;Cell Separation;Cells;Collaborations;Color;Communication;Computer software;Contract Services;Core Facility;cost effectiveness;Cytometry;Data Analyses;Development;Doctor of Philosophy;Emerging Technologies;Employee;Equipment;Evaluation;experience;Experimental Designs;experimental study;Faculty;Feedback;Flow Cytometry;Flow Cytometry Shared Resource;Funding;Grant;Image;Image Cytometry;Immune;Immunophenotyping;Institution;instrument;instrumentation;investigator training;Lasers;Leadership;Licensing;Maintenance;Malignant Neoplasms;Manuscripts;meetings;member;Microfluidics;Monitor;NCI-Designated Cancer Center;Patients;Phenotype;Population;Preparation;programs;Protocols documentation;Publications;repaired;Research;Research Personnel;Resource Sharing;Science;Scientist;Services;Site;skills;Solid Neoplasm;Sorting;Speed;Stains;Surveys;Suspensions;Technology;technology platform;Training;tumor;Work

PROJECT_TITLE: Flow Cytometry


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cost Effectiveness Research;Genetics;Human Genome

PI_NAMEs: ADAMS, PETER D. (contact)

PROJECT_TERMS: Acceleration;analysis pipeline;automated analysis;Bioinformatics;Biological;Cancer Center;Cancer Center Support Grant;Cells;ChIP-seq;Chromium;Collaborations;Communication;Complex Analysis;Computer software;Contract Services;Core Facility;cost;cost effectiveness;Cost Effectiveness Analysis;CRISPR library;Data;Data Analyses;design;Disease;Doctor of Philosophy;Employee;Epigenetic Process;Equipment;exome sequencing;experience;Experimental Designs;experimental study;Faculty;Feedback;Flow Cytometry;Funding;Gene Expression Profiling;Genomics;Genomics Shared Resource;Grant;High-Throughput Nucleotide Sequencing;Human Cell Line;Individual;Institution;Large-Scale Sequencing;Leadership;Libraries;Maintenance;Malignant Neoplasms;meetings;member;multiple omics;next generation sequencing;Nucleic Acids;Outsourcing;Pathway interactions;Phage Display;Preparation;programs;Promega;Publications;recruit;repaired;Research;Research Personnel;Resource Sharing;Resources;Science;Scientist;Sequence Analysis;Services;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;success;Surveys;System;Technology;transcriptome sequencing;Work

PROJECT_TITLE: Genomics


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: PASQUALE, ELENA B (contact)

PROJECT_TERMS: Acceleration;Affinity Chromatography;Automation;biomarker discovery;Cancer Center;Cancer Center Support Grant;Communication;Computer software;Contract Services;Core Facility;cost effective;cost effectiveness;Coupled;Data Analyses;Development;Doctor of Philosophy;drug discovery;Drug Targeting;Employee;Epitopes;Equipment;Experimental Designs;Faculty;Feedback;Funding;Generations;Grant;Histones;Institution;Label;Laboratories;Leadership;Location;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;meetings;member;Methodology;Methods;Mission;Pathway interactions;phosphoproteomics;Post Translational Modification Analysis;Post-Translational Protein Processing;Preparation;programs;protein protein interaction;Proteins;Proteomics;Proteomics Shared Resource;Publications;recruit;repaired;Research;Research Design;Research Personnel;Resource Sharing;Sampling;Science;Scientist;Services;Surveys;System;Technology;tool;Training;Work

PROJECT_TITLE: Proteomics


PI_NAMEs: JACKSON, MICHAEL  (contact)

PROJECT_TERMS: Acceleration;Advanced Development;assay development;Award;Basic Science;Biochemical Process;Biological Assay;Biology;Cancer Center;Cancer Center Support Grant;Carbon Dioxide;Cell Physiology;cellular targeting;Chemicals;Collection;Communication;Computer software;Contract Services;Core Facility;cost effectiveness;Data;Data Analyses;Dedications;Detection;Development;Doctor of Philosophy;drug discovery;Drug Kinetics;drug metabolism;Employee;Equipment;Experimental Designs;Faculty;Feedback;follow-up;Genomics;Goals;Grant;Growth;high throughput screening;In Vitro;in vivo;Infrastructure;Institution;instrument;instrumentation;Laboratories;Lead;Leadership;Libraries;Liquid substance;live cell imaging;Maintenance;Malignant Neoplasms;meetings;member;Molecular Bank;multiparametric imaging;novel;Pathogenesis;Pharmaceutical Chemistry;Pharmaceutical Preparations;Philanthropic Fund;preclinical development;Production;programs;Property;Publications;repaired;Research;Research Personnel;Resource Sharing;Resources;Science;Scientist;screening;Services;small molecule;small molecule libraries;square foot;Surveys;System;Technology;Temperature;Translating;Translations;tumor;tumor initiation;United States National Institutes of Health;Validation;validation studies;Work

PROJECT_TITLE: Chemical Library Screening


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Serious Mental Illness

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The efficient assessment of Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) is a significant impending public health challenge. The proposed project aims to study digital biomarkers from large language models as a novel methodology and to apply them to quantify MDD and GAD symptoms. The project aims to increase our understanding of depression and anxiety by examining and preliminarily validating computational linguistic features, and will result in an improved empirical framework and associated digital tools to move psychiatric assessment of MDD and GAD from subjective ratings.

PI_NAMEs: MALGAROLI, MATTEO  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Accounting;Address;Algorithms;Anxiety;Artificial Intelligence;Attention;Award;base;Behavior assessment;behavioral health;biomarker identification;Caring;Classification;Clinical;Cognitive;comorbidity;Computational Linguistics;Data;Decision Making;deep learning;deep learning model;design;Detection;Development;Diagnosis;diagnostic strategy;Dictionary;Digital biomarker;digital health;digital tool;Dimensions;disability;economic cost;Emotional;emotional stimulus;Engineering;Evaluation;experience;Future;Generalized Anxiety Disorder;Goals;Health;Heterogeneity;Human;Impairment;improved;Individual;Intervention;Interview;K-Series Research Career Programs;Language;large language model;Learning;Linguistics;loss of function;Major Depressive Disorder;Measurement;Measures;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methodology;Methods;Modeling;Monitor;Morality;multidisciplinary;Natural Language Processing;Negative Valence;neuroeconomics;novel;Outpatients;Patient Self-Report;Patients;Pattern;Performance;Population;Positive Valence;programs;Protocols documentation;Psychiatry;Psychotherapy;Public Health;Quality of life;Reaction;recruit;Research;Research Domain Criteria;response;Rewards;Risk;Sampling;scalable algorithms;Scientific Advances and Accomplishments;screening;Security;Source;Standardization;suicidal risk;Symptoms;System;Testing;tool;Training;trait;Transcript;Validation

PROJECT_TITLE: Deep Learning Based Natural Language Processing Markers of Anxiety and Depression

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: YIP, YUK-LAP KEVIN (contact)

PROJECT_TERMS: Acceleration;Applications Grants;Bioinformatics;Bioinformatics Shared Resource;Biological;Biology;Biometry;Cancer Center;Cancer Center Support Grant;cancer genomics;Chemicals;Communication;Computer software;computerized data processing;Consultations;Contract Services;Core Facility;cost effectiveness;Data;Data Analyses;data integration;data mining;Data Set;Databases;Doctor of Philosophy;Employee;Equipment;Experimental Designs;Faculty;Feedback;functional genomics;genomic data;Genomics;Grant;High Performance Computing;improved;Information Systems;innovation;Institution;Leadership;Licensing;Machine Learning;Maintenance;Malignant Neoplasms;meetings;member;Mission;multiple data types;Process;programs;Proteomics;Publications;recruit;repaired;Research;Research Personnel;Resource Sharing;Science;Scientist;Services;statistics;Surveys;Systems Biology;Techniques;Technology;Time;Training;Visualization;web services;Work;Yin

PROJECT_TITLE: Bioinformatics


PI_NAMEs: DESHPANDE, ANIRUDDHA J. (contact)

PROJECT_TERMS: Acceleration;Adenoviruses;Adopted;antagonist;assay development;Automation;Bioinformatics Shared Resource;Biological Assay;Cancer Center;Cancer Center Support Grant;Cell Line;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Computer software;Contract Services;Core Facility;cost effectiveness;CRISPR library;CRISPR screen;CRISPR/Cas technology;Cultured Cells;Custom;Data;Data Analyses;Dedications;design;Doctor of Philosophy;Employee;Engineering;Equipment;exome;Experimental Designs;Faculty;Feedback;functional genomics;Gene Activation;Gene Family;gene repression;Genetic;Genetic Screening;genome-wide;Genomics Shared Resource;Goals;Grant;Guide RNA;high throughput screening;Image;inhibitor;Institution;Label;Laboratories;Leadership;Libraries;Maintenance;Malignant Neoplasms;meetings;member;Methods;MicroRNAs;Microscopy;Miniaturization;Mutation;nucleic acid delivery;Patients;Preparation;programs;Publications;Reagent;repaired;repository;Research;Research Personnel;Resource Sharing;RNA Interference;Science;Scientist;screening;Services;small hairpin RNA;Small Interfering RNA;small molecule libraries;Statistical Data Interpretation;Supporting Cell;Surveys;System;Technology;Time;tool;vector;Viral;Viral Vector;whole genome;Work

PROJECT_TITLE: Functional Genomics


NIH_SPENDING_CATS: Bioengineering;Cancer

PROJECT_TERMS: Acceleration;analytical method;anti-cancer research;Applications Grants;Bioenergetics;Cancer Center;Cancer Center Support Grant;Cell Respiration;Cells;Cholesterol;Citric Acid Cycle;Collaborations;Communication;Computer software;Contract Services;Core Facility;cost effectiveness;Data Analyses;design;Detection;Doctor of Philosophy;Employee;Equipment;experience;Experimental Designs;extracellular;Faculty;Fatty Acids;Feedback;Funding;Future;Genus Hippocampus;Glucose;Glutamates;Glutamine;Glycolysis;Grant;immune cell infiltrate;inhibitor;insight;Institution;instrument;instrumentation;interest;Label;Leadership;Maintenance;Malignant Neoplasms;Mass Fragmentography;Measures;Medical;meetings;member;Metabolic;metabolic abnormality assessment;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Methodology;Methods;Mitochondria;Nucleotides;Oxidative Phosphorylation;Oxygen Consumption;Production;programs;Publications;repaired;Research;Research Personnel;Resource Sharing;Resources;response;Sampling;Science;Scientist;Services;stable isotope;sugar;Sugar Phosphates;Surveys;Technology;temporal measurement;tumor;tumor metabolism;Volatile Fatty Acids;Work

PROJECT_TITLE: Cancer Metabolism


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE While the nature of stimulus representation in visual cortex has been heavily studied, relatively little attention has been given to the impact of active task engagement on stimulus-driven visual responses. Using a multidisciplinary approach combining cutting-edge methodological development, extensive high-field (7T) fMRI measurements, theory-driven experimental design, and computational modeling, this project aims to develop formal models characterizing how engagement in different perceptual and cognitive tasks modulates visually- driven responses. Completion of this work will yield reusable methods, data resources, and models of visual information processing. Progress in identifying the computational mechanisms underlying visual perception in healthy individuals is a critical step for understanding the nature of sensory disorders such as prosopagnosia and dyslexia.

PI_NAMEs: CURTIS, CLAYTON E;KAY, KENDRICK NORRIS (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Algorithms;Area;Attention;Behavior;Benchmarking;blood oxygenation level dependent response;Brain;Cognitive;cognitive control;cognitive neuroscience;cognitive process;cognitive task;Complex;computational neuroscience;Computer Models;Data;data resource;data reuse;Data Set;Decision Making;deep neural network;Development;Dyslexia;Estimation Techniques;Event;experience;Experimental Designs;experimental study;extrastriate visual cortex;frontal lobe;Functional Magnetic Resonance Imaging;Goals;Grant;hemodynamics;Human;Image;improved;Individual;information processing;Instruction;interdisciplinary approach;Interdisciplinary Study;intraparietal sulcus;Investigation;Investments;Laboratories;Libraries;Linear Models;Maps;Measurement;Mediating;Methodology;Methods;Modeling;multidisciplinary;Nature;neural;Neural Network Simulation;neuroimaging;Noise;novel;Participant;Performance;predictive modeling;Primates;programs;Prosopagnosia;Research;Research Personnel;Resolution;Resources;response;Response to stimulus physiology;Sampling;Sensory;Sensory Disorders;Short-Term Memory;Signal Transduction;Software Tools;Source;Specificity;Stimulus;success;Support System;Techniques;Temporal Lobe;Testing;theories;tool;Variant;Venous;Visual;Visual Cortex;visual information;visual neuroscience;Visual Perception;visual processing;visual stimulus;Visual System;Work

PROJECT_TITLE: Deep sampling of cognitive effects in the human visual system

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Prevention;Radiation Oncology;Rare Diseases;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative A new platform is envisioned that combines two existing technologies to produce a low cost, simple to use, handheld device that can screen patients for high-risk oral cancer, image the location of the cancer, and treat it using this same device at point of care. It includes testing therapeutic efficacy both pre-clinically and clinically in patients, along with identification of an easy-to-use topical application of the therapeutic agent well suited for low-income settings. The impact of these studies could be substantial in the low-income settings such as rural areas and can avoid deaths in the regions where oral cancer is highly prevalent in India as well as other countries including regions of the U.S.A.

PI_NAMEs: CELLI, JONATHAN P;HASAN, TAYYABA  (contact);LIANG, RONGGUANG

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: 3-Dimensional;Address;Adhesives;Adoption;Aftercare;Agreement;Aminolevulinic Acid;Artificial Intelligence;Artificial Intelligence enhanced;Artificial Intelligence platform;Astronomy;Award;cancer site;Capital;carcinogenicity;Carcinogens;Carcinoma in Situ;Cessation of life;Cheek structure;Classification;Clinical;clinical center;clinical implementation;cloud based;cohort;Collaborations;convolutional neural network;cost;Country;Data;deep learning;design;Detection;Development;Devices;Diagnosis;Disease;Disease Progression;dosimetry;Eligibility Determination;Engineering;ergonomics;experience;Family suidae;FDA approved;Fluorescence;Future;Germany;Goals;Hamsters;handheld equipment;healing;High grade dysplasia;high risk;Histologic;Histopathology;Image;image guided;imaging approach;Imaging Device;imaging system;In Vitro;Incidence;inclusion criteria;Income;India;Individual;Industry;Infrastructure;innovation;intraoral probe;Lesion;Letters;Light;light weight;Low income;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;Mastication;Medical;meetings;Modality;Modeling;molecular imaging;Monitor;Mucous Membrane;Mus;Oncologist;Optics;Oral;Oral cavity;oral lesion;Oral mucous membrane structure;oral premalignancy;Oral Stage;Outcome;Participant;Pathology;patient screening;Patients;Penetration;Performance;Photobleaching;Photochemistry;Photosensitization;Photosensitizing Agents;point of care;portability;pre-clinical;preclinical study;premalignant;Property;Public Health;PUVA Photochemotherapy;Radiation therapy;Resource-limited setting;response;rural area;rural setting;Safety;Scientist;screening;Screening for cancer;Screening for Oral Cancer;Sensitivity and Specificity;Site;subcutaneous;success;Surgeon;Surgical Oncology;System;systemic toxicity;Technology;Testing;Therapeutic Agents;therapeutic evaluation;Time;Topical application;Training;Treatment Efficacy;tumor;Tumor Burden;Validation;validation studies;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: A comprehensive platform for low-cost screening and image-guided photodynamic therapy (PDT) of pre-malignant and malignant oral lesions in low resource settings


PROJECT_TERMS: Address;anti-cancer research;Area;Award;Basic Cancer Research;Cancer Center;Cancer Center Support Grant;Cancer Research Project;Capital;cost;Development;Direct Costs;Equilibrium;Equipment;Evaluation;Faculty;Faculty Recruitment;Funding;Goals;graduate student;Grant;innovation;Institution;Investments;Leadership;Medical;member;Modeling;Peer Review;Pilot Projects;Postdoctoral Fellow;programs;Publications;recruit;Research;Research Assistant;Research Personnel;Research Support;Science;Scientist;Secure;Strategic Planning;success;Wages

PROJECT_TITLE: Developmental Funds


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Cardiovascular disease outcomes are aggravated in patients presenting with concurrent atherosclerosis and diabetes, although the mechanisms responsible are not fully understood. Here we will study how an axis involving the TFEB gene and its target, GPNMB, can restore the function of the endothelium, the internal layer of the blood vessels, in models of atherosclerosis associated with diabetes. We will use a novel pharmacologic strategy that allows the production, by the body itself, of a potent anti-inflammatory molecule, NO2-CLA (pronounced, nitro-CLA) starting from dietary supplements to activate TFEB and increase GPNMB and reduce atherosclerosis associated with diabetes, which could change current clinical paradigms for the treatment of cardiometabolic diseases.

PI_NAMEs: CHEN, YUQING EUGENE (contact);GARCIA-BARRIO, MINERVA T

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Acceleration;Accounting;Address;Adult;Adverse effects;angiogenesis;Animal Model;Animals;Anti-diabetic Drugs;Anti-Inflammatory Agents;Aorta;atheroprotective;Atherosclerosis;atherosclerosis risk;Autophagocytosis;Biogenesis;Blood Vessels;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular disorder therapy;Cardiovascular Models;Cause of Death;Cell Separation;Cells;Cessation of life;Child;Clinical;Clinical Treatment;Conjugated Linoleic Acids;Coronary artery;Data;Development;diabetes management;Diabetes Mellitus;diabetic;diabetic patient;diabetogenic;Diet;diet-induced obesity;dietary;dietary supplements;Disease;Disease Outcome;Endothelial Cells;Endothelium;Exposure to;Fatty Acids;Functional dependence;Functional disorder;functional restoration;gain of function;Genes;Genetic Engineering;Genetic Transcription;Glucose;glucose tolerance;glycoprotein NMB;Glycoproteins;Goals;Homeostasis;Human;Hyperglycemia;Hypertriglyceridemia;Hypoglycemic Agents;improved;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;insulin sensitivity;Intervention;Ischemia;Knock-out;Knockout Mice;loss of function;Mediating;Mediator;Melanoma;Metabolic Diseases;Modeling;mortality;mouse model;Mus;Myocardial Infarction;nanomolar;Neurodegenerative Disorders;nitrated conjugated linoleic acid;nitration;Nitric Oxide;Nitrites;Nitrogen Dioxide;Nonmetastatic;novel;novel therapeutic intervention;Nuclear Translocation;Obesity;Oleic Acids;Oral;Oxidative Stress;Pathogenesis;Pathology;Patients;Peripheral Vascular Diseases;Persons;Pharmaceutical Preparations;pharmacologic;Phase II Clinical Trials;Plasma;Play;Population;preclinical trial;Prediabetes syndrome;Prevalence;prevent;Process;Production;Property;protective effect;protein B;prototype;Publishing;Regulation;Reporting;Research;Residual state;Risk;risk minimization;Role;single-cell RNA sequencing;Site;Stimulus;Stomach;Stroke;Technology;Testing;Therapeutic;Tissues;transcription factor;transcriptome sequencing;Transgenes;Transgenic Organisms;Translations;Work

PROJECT_TITLE: Nitro-Fatty Acids and Cardiovascular Disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


PROJECT_TERMS: Accreditation;Animal Model;Area;Award;Basic Cancer Research;Basic Science;Bioinformatics;Biology;Cancer Center;Cancer Center Support Grant;cancer therapy;career;Cessation of life;Chemicals;Dedications;Development;Disease;Education;Elements;Epigenetic Process;Evaluation;Faculty;Funding;Future;Genetically Engineered Mouse;Goals;Grant;Growth;Hospitals;Human;human tissue;Immunology;Improve Access;Joints;Lead;Leadership;Malignant Neoplasms;Medical;meetings;member;Mentors;Metabolism;Minority;Mission;Modality;multidisciplinary;NCI Center for Cancer Research;novel therapeutics;Outcome;Pilot Projects;Prevention;Process;programs;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Science;single cell sequencing;small molecule;Strategic Planning;structural biology;System;Technology;Therapeutic;Training;Translating;vaccinology;Vision

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Orphan Drug;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Many metastases of breast cancer may further disseminate to seed more metastases, but the pre-clinical models, the underlying mechanisms, and the potential therapeutic targets are all lacking. Herein, based on several lines of preliminary evidence, we propose to test the hypothesis that the bone microenvironment invigorates metastatic seeds for further dissemination. Specifically, we will focus on delineation of temporal course of metastatic seeding from bone to other organs, and identification of druggable pathways driving this process.

PI_NAMEs: ZHANG, XIANG  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Adjuvant;Affect;Automobile Driving;Bar Codes;bone;bone cell;Brain;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;cancer cell;cancer stem cell;Cell Line;Cessation of life;Circulation;Complement;CRISPR/Cas technology;Data;design;Destinations;Diagnosis;Distant;druggable target;Epigenetic Process;epigenomics;Evolution;fetal;genetic selection;genomic locus;Genomics;Guide RNA;high risk;inducible gene expression;innovation;insight;Investigation;Kinetics;Lesion;limb bone;Liver;Lung;Malignant Bone Neoplasm;Malignant Breast Neoplasm;Mediating;Metastatic Neoplasm to the Bone;Micrometastasis;Modeling;Mutate;Neoplasm Metastasis;novel therapeutics;Organ;Outcome;Parabiosis;Pathway interactions;patient derived xenograft model;Patients;Phenotype;Pre-Clinical Model;prevent;Prevention;Primary Neoplasm;Process;Prognosis;Property;Recurrence;Research;restraint;Site;Skeleton;stem;stemness;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;tumor;Visceral;Work

PROJECT_TITLE: Mechanistic and therapeutic investigation of secondary metastatic seeding from breast cancer bone lesion

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative Breast cancer brain metastasis is observed in up to 50% of HER2-positive breast cancer patients and patients survive less than 2 years following CNS involvement. CAR T cells are a promising new treatment but typically results in poor responses against solid tumors. This proposal seeks to apply thermal targeting by Magnetic Resonance guided Focused Ultrasound to increase anti-HER2 CAR T cell delivery and potentiate therapy against breast cancer brain metastasis.

PI_NAMEs: ARVANITIS, KONSTANTINOS-COSTAS  (contact);KALINSKY, KEVIN MICHAEL;KWONG, GABRIEL A;WOODWORTH, GRAEME F

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Address;Algorithms;Animals;Antigen Receptors;Antigens;Antitumor Response;Benchmarking;bi-specific T cell engager;blood-brain barrier permeabilization;Brain;Brain Neoplasms;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer Treatment;Cancer Relapse;CAR T cell therapy;CD3 Antigens;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;Clinical;clinical translation;Clinical Trials;clinically relevant;combat;cranium;cytotoxic;Disease;Dose;Drug Delivery Systems;effective therapy;efficacy evaluation;engineered T cells;Engineering;ERBB2 gene;Focused Ultrasound;Focused Ultrasound Therapy;Grant;Granzyme;Hematopoietic Neoplasms;Hemorrhage;Human;Hyperthermia;hyperthermia treatment;image guided;image guided therapy;Immune system;improved;In Vitro;Induced Hyperthermia;Infiltration;Intravenous;Ligands;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Breast Neoplasm;MDA-MB-468;member;Metastatic breast cancer;Metastatic malignant neoplasm to brain;Methods;migration;minimally invasive;Modeling;mouse model;Mus;neoplastic cell;neuron loss;novel therapeutic intervention;Outcome;Patients;perforin;Perfusion;Permeability;preclinical evaluation;preclinical study;Production;Proliferating;Protocols documentation;Relapse;Reporting;response;safety assessment;skin burn;Solid Neoplasm;Sonication;Stains;Switch Genes;systemic toxicity;T cell infiltration;T cell response;T-Cell Homing Receptors;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;Toxic effect;trafficking;Transgenic Mice;Transgenic Organisms;Translations;Treatment Efficacy;Treatment Protocols;tumor;tumor heterogeneity;Xenograft Model

PROJECT_TITLE: Breast Cancer Brain Metastasis Therapy by Focused Ultrasound-Guided Control of HER2 CAR T cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-J(03)M]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition;Obesity

ORG_CITY: PROVIDENCE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Dysregulation of feeding results in obesity or in malnutrition and the various morbidities associated with these conditions. Therefore, to better tackle the challenges of obesity and malnutrition, we must better understand the neural mechanisms that modulate feeding. Further, because insect-born diseases are a major human health challenge and insect agricultural pests are key contributors to human malnutrition, the studies presented here will contribute to better understanding of the control of insect feeding and may therefore have a major impact on global human health.

PI_NAMEs: BARNEA, GILAD  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Abdomen;Address;adipokinetic hormone;Adult;Affect;Agriculture;analog;Anatomy;Animals;Anterior;Area;Behavior;Behavioral;Brain;Calcium;Calories;Complement;connectome;corpus cardiacum;Data;Decision Making;Desire for food;Digestion;Discrimination;Disease;Disease Vectors;Diuretics;Drosophila genus;Equilibrium;Evaluation;experimental study;Exposure to;feeding;Feeding behaviors;fly;Food;Food Preferences;food quality;Glucagon;Glucose;Health;Hemolymph;Hormones;Horns;Human;Hunger;Image;in vivo;Ingestion;Insect Control;Insecta;interest;Ion Transport;Label;Lateral;Location;Malnutrition;Malpighian Tubules;Mammals;Maps;Metabolic;Methods;model organism;Morbidity - disease rate;Mushroom Bodies;mutant;Nerve;neural;neural network;neuromechanism;Neuromodulator;Neurons;neuropeptide F;Neuropeptides;Neuropil;neuroregulation;Nutrient;Nutrition Assessment;Nutritional;Obesity;Organ;Peptide Transport;postsynaptic neurons;Process;Publishing;receptor;Receptor Activation;receptor expression;reduced food intake;Regulation;Research;Resolution;response;Role;Satiation;Shapes;Signal Transduction;Site;Source;Stereotyped Behavior;Stereotyping;Stream;Structure;sugar;Synapses;System;Tachykinin;Taste Perception;Techniques;Technology;Testing;tool;Toxin;Water

PROJECT_TITLE: A Neuropeptidergic Neural Network Integrates Taste with Internal State to Modulate Feeding

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative IgE antibodies are significant contributors to the pathogenesis of allergic diseases. Repetitive exposure to particular antigens induces the production of specific IgE antibodies in susceptible individuals, yet the underlying mechanisms are unclear. In this project, we will study the mechanisms that regulate the generation and fate of IgE-producing cells upon repetitive antigen exposure.

PI_NAMEs: ALLEN, CHRISTOPHER DAVID CABALLERO (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Affect;Affinity;Allergic;Allergic Disease;Antibodies;Antigens;B-Cell Antigen Receptor;B-Lymphocyte Subsets;B-Lymphocytes;Biology;Cells;Characteristics;cytokine;Data;Detection;Disease;Exposure to;Flow Cytometry;food antigen;Generations;Goals;Human;Hypersensitivity;IgE;IgG1;Immune response;Immunization;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;improved;Individual;insight;interleukin-21;Lead;Memory B-Lymphocyte;Methodology;Microscopy;Mus;novel strategies;pathogen;Pathogenesis;Plasma Cells;Play;Predisposition;Procedures;Production;Regulation;Reporter;response;Role;Sampling;Secondary Immunization;Secondary to;Signal Transduction;Specificity;Stable Populations;Stains;Structure of germinal center of lymph node;Vaccination

PROJECT_TITLE: Cellular Origin of IgE Recall Responses

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHAMPAIGN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Oxidative stress can be an overwhelming force in the microbial world. Sensitivity to oxygen restricts the environments in which many microbes can live, and reactive oxygen species serve as weapons by which hosts, competitors, and redox-active drugs attack them. By revealing the molecular details of this stress, we will be able to understand the variability in oxidant tolerance among species, and we will become cognizant of the important situations in which oxidative stress plays a decisive role in microbial fate.

PI_NAMEs: IMLAY, JAMES A. (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acetates;Aerobic;Affect;Alcohol dehydrogenase;Anoxia;Appearance;Binding Sites;Biochemical;biological adaptation to stress;Bypass;cell growth;Cell Physiology;Cells;Cellular Stress;Chemistry;Collaborations;constitutive expression;Cysteine;Data;Dedications;Disease;dithiol;DNA Damage;Electrons;Environment;Enzymes;Escherichia coli;Event;Family;Fermentation;fitness;formate acetyltransferase activating enzyme;Formates;Genes;Glucose;glutaredoxin;Goals;Grant;Growth;Grx1 protein;Hydrogen Peroxide;Hydroxyl Radical;Impairment;In Vitro;in vivo evaluation;Injury;Iron;iron oxidation;Knowledge;Learning;Literature;Lyase;Mass Spectrum Analysis;Measurement;Mediating;member;Metabolic;Metabolism;Metal Binding Site;metalloenzyme;Methionine;methionine sulfoxide;Microbe;microbial;Minor;Modeling;Modification;Molecular;Mononuclear;Names;Natural regeneration;Oxidants;oxidation;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Oxygen;Peroxides;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Play;Price;Proteins;Proteome;Pyruvate;Pyruvate Metabolism Pathway;Reaction;Reactive Oxygen Species;reconstruction;redoxin;Regulon;repaired;response;Role;side effect;Site;Solvents;Source;Stress;Sulfate;Sulfhydryl Compounds;Sulfur;Sulfur Metabolism Pathway;Superoxides;System;Testing;Thioredoxin-2;Toxic effect;transcriptome sequencing;transcriptomics;TXN gene;wasting;weapons;Work;Zinc

PROJECT_TITLE: The Physiology of Oxidative Stress in Escherichia coli

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: The objective of this study is to elucidate the role of Epac1 in diabetic retinopathy, the leading cause of blindness in adults, and to investigate the potential of Epac specific inhibitors as novel therapeutics for diabetic retinopathy.

PI_NAMEs: CHENG, XIAODONG  (contact);LIU, HUA

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Adult;Age;aged;American;angiogenesis;Apoptosis;Applied Genetics;Attenuated;bevacizumab;biological adaptation to stress;Biology;Blindness;Blood capillaries;Blood Vessels;Calcineurin;calmodulin-dependent protein kinase II;Centers for Disease Control and Prevention (U.S.);Chronic;Clinical;Collaborations;Complications of Diabetes Mellitus;Cyclic AMP;Development;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Disease;Dropout;Dynamin;E-Box Elements;Elements;Endothelial Cells;Endothelium;Etiology;Eye diseases;Face;Functional disorder;gamma secretase;Genetic;Glucose;Hyperglycemia;Hypoxia;Hypoxia-Responsive Elements;improved;in vivo;in vivo evaluation;inhibitor;innovation;insight;Intervention;intravitreal injection;KDR gene;Knockout Mice;Laboratories;Lead;Mediating;Medical;Mitochondria;Molecular;mouse model;Mus;neovascularization;new therapeutic target;notch protein;Notch Signaling Pathway;novel;novel therapeutic intervention;novel therapeutics;Oxygen;Pathogenesis;Pathogenicity;Pathologic Neovascularization;Pericytes;Pharmaceutical Preparations;pharmacologic;Play;Population;prevent;Prevention;Production;promoter;Prophylactic treatment;Proteins;Reactive Oxygen Species;Reperfusion Therapy;Retina;retinal damage;Retinal Diseases;retinal ischemia;Role;Second Messenger Systems;secretase;Signal Transduction;Site;standard care;Stress Response Signaling;Symptoms;Testing;Therapeutic;therapeutic target;therapeutically effective;trafficking;Vascular Diseases;Vascular Endothelial Growth Factors;Vascular remodeling

PROJECT_TITLE: Epac1 as a novel therapeutic target for diabetic retinopathy

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: BAMAKO

ORG_COUNTRY: MALI

ORG_FIPS: ML

ORG_NAME: UNIV OF SCIENCES, TECH & TECH OF BAMAKO

PHR: NARRATIVE This project will identify clinical, psychosocial, and genetic elements of epilepsy in Mali, with the goal of utilizing the data to improve care and quality of life for people with epilepsy in Mali, sub-Saharan Africa, and even more broadly. Moreover, this project will promote education and community engagement and to reduce stigma and other psychosocial burdens of epilepsy. It will also build scientific expertise and infrastructures to further the study of epilepsy and other diseases by African scientists in Africa.

PI_NAMEs: LAKHANI, SAQUIB A;LANDOURE, GUIDA  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Achievement;Address;Affect;Africa;Africa South of the Sahara;African;anti-epileptic agents;Anxiety;Applications Grants;Area;Attention;Awareness;Basic Science;Bioinformatics;Biological Models;Brain Injuries;burden of illness;Candidate Disease Gene;candidate identification;care providers;care seeking;Caring;Child;Childhood;Clinical;Collaborations;community engagement;Counseling;CRISPR/Cas technology;Critical Illness;Data;design;Developing Countries;Development;Diagnosis;diagnostic value;Disease;Disparity;DNA;DNA sequencing;Economic Burden;Economics;Education;efficacy evaluation;Electroencephalography;Epidemiology;Epilepsy;Equity;Evaluation;experimental study;Family;Foundations;Fright;Future;Genes;Genetic;genetic analysis;genetic element;Genetic Predisposition to Disease;Genetic Research;genetic variant;Genomics;Genotype;Goals;Health Personnel;imaging study;improved;in vivo Model;Inequity;Infrastructure;insight;low and middle-income countries;Maintenance;Mali;Mental Depression;Mentors;Mentorship;Methodology;Nervous System Disorder;neurogenetics;Neurologic;next generation;next generation sequencing;novel;patient engagement;Patients;Persons;Pharmaceutical Preparations;Phenotype;Population;prevent;Prognosis;programs;Provider;psychosocial;public education;Public Health;Public Policy;Quality of life;Rana;Rare Diseases;recruit;Reporting;Research;Research Infrastructure;Research Personnel;Resources;Sampling;Schedule;Scientist;Seizures;Site Visit;social;social stigma;Students;Surveys;Testing;tool;Training;Translational Research;Universities;Variant;Visit;Work;Xenopus

PROJECT_TITLE: Genetics of Epilepsy in Mali (GENEP-Mali)


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE FLT3 is a protein that is mutated in acute myeloid leukemia (AML) and causes an aggressive form of blood cancer. I have found a new function of FLT3 that keeps leukemia cells from becoming healthy blood cells and will investigate potential ways to use this to develop new therapies.

PI_NAMEs: SUNG, PAMELA JEANNETTE (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Advisory Committees;Area;Biochemical;Biological Availability;Biology;Blast Cell;Blood Cells;Bone Marrow;career;career development;Cell Line;Cell Proliferation;Cell Survival;ChIP-seq;Clinical;clinical efficacy;Clinical Trials;Complex;CRISPR/Cas technology;Cycloheximide;cytokine;Data;derepression;Development Plans;Disease;Down-Regulation;Dysmyelopoietic Syndromes;Enhancers;Epigenetic Process;epigenetic regulation;epigenome;experience;Faculty;FDA approved;Flow Cytometry;FLT3 gene;FLT3 inhibition;FLT3 inhibitor;Foundations;functional genomics;gene repression;Generations;Genes;Genetic;Goals;Half-Life;Hematology;Hematopoiesis;Hematopoietic Neoplasms;histone methylation;histone methyltransferase;histone modification;Homologous Gene;Human;improved;In Vitro;in vivo;Induction of Apoptosis;insight;Institution;JAK2 gene;Label;Laboratories;Laboratory Research;leukemia;Leukemic Cell;leukemogenesis;Link;Lysine;Maintenance;Malignant Neoplasms;MAP Kinase Gene;Mentors;Mentorship;Methodology;Modeling;mouse model;Mus;mutant;Mutate;Mutation;Myelogenous;Myeloproliferative disease;New Agents;novel;novel therapeutics;Oncology;overexpression;Pathway interactions;Patients;Pennsylvania;pharmacologic;Phosphotransferases;Physicians;Physiologic pulse;Polycomb;Post-Transcriptional Regulation;posttranscriptional;Prognosis;Proteasome Inhibition;Proteins;Proteome;Proteomics;proto-oncogene protein pim;receptor;Regulation;Research;resistance mechanism;response;RNA;Role;Sampling;Scientist;Signal Pathway;Signal Transduction;skills;Specificity;Stat5 protein;stem;stem cells;Structure;targeted treatment;Testing;Therapeutic;Training;Transcription Repressor;transcriptome sequencing;Translational Research;Undifferentiated;Universities;Western Blotting

PROJECT_TITLE: Improving targeted therapy in FLT3-mutated AML

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Epilepsy;Genetics;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Patients with Alzheimer’s disease (AD) experience seizures, although these events are commonly non-convulsive in nature and thus potentially missed. Despite this, little is known regarding the direct long-term impact of untreated seizures on disease progression in patients with AD. This study will directly define whether chronic seizures age-dependently aggravate neuropsychiatric comorbidities of AD.

PI_NAMEs: BARKER-HALISKI, MELISSA LEIGH (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: abeta accumulation;Acceleration;Address;Affect;Age;age related;Age related pathologies;aged;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Anxiety;anxiety-like behavior;associated symptom;autosome;Behavioral;beta amyloid pathology;burden of illness;Caregivers;Chronic;circadian;Clinical;Clinical Research;comorbidity;Cornea;cytokine;Data;Deposition;Development;Disease;Disease Progression;DNA Sequence Alteration;Early Onset Alzheimer Disease;Epilepsy;Epileptogenesis;Event;Exhibits;experience;Focal Seizure;Functional disorder;Genes;genetic variant;Genotype;Goals;Hippocampus;hyperphosphorylated tau;Immediate-Early Genes;Impact Seizures;In Vitro;Incidence;Inflammatory;Knockout Mice;Knowledge;Language;Measures;Medical;Mental Depression;Modeling;Molecular;molecular marker;Mus;Mutant Strains Mice;Mutation;Nature;neuroinflammation;Neuronal Plasticity;neuropathology;neuropsychiatric symptom;neuropsychiatry;old mice;overexpression;Pathology;Patients;Pattern;pre-clinical;Pre-Clinical Model;presenilin;presenilin-1;presenilin-2;Process;protein expression;Protein Overexpression;Quality of life;Reporting;Risk Factors;risk variant;Role;Seizures;Senile Plaques;Severities;Sleep disturbances;Sleep Wake Cycle;Synaptic plasticity;Testing;Transgenic Mice;Variant;Wild Type Mouse;Work

PROJECT_TITLE: Impact of Chronic Seizures on Neuropsychiatric Comorbidities in AD-Associated Models


NIH_SPENDING_CATS: Aging;Clinical Research;Digestive Diseases;HIV/AIDS;Infectious Diseases

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE In individuals with HIV infection, chronic inflammation is present even with undetectable viral loads, and such persons often present with co-morbidities associated with older age, including bone loss, cancers, stroke, cardiovascular disease, and dementia. In this application, we propose to test the hypothesis that gamma delta T cells, a unique ‘innate-like’ T cell subset, exhibit hyper-inflammatory activity in the gastrointestinal tract of aviremic HIV+ individuals and uninfected older subjects, and this aberrant activation directly causes increased permeability of intestinal epithelium, leading to movement of GI microbial products and inflammatory gamma delta T cells into the circulation, which spurs and propagates systemic inflammation. Identification of the mechanisms driving increased intestinal permeability with aviremic HIV infection and normal aging is critical to develop novel therapeutic strategies to abrogate and/or prevent age-associated co-morbidities.

PI_NAMEs: SNYDER-CAPPIONE, JENNIFER E (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Age;age effect;Age related comorbidities;age-related disease;aged;Aging;Algorithms;antagonist;Architecture;Automobile Driving;Bioinformatics;Biological;Biopsy;Blood;bone loss;Cardiovascular Diseases;Cell Culture Techniques;Cell Lineage;Cell Physiology;Cell Separation;Cells;Cessation of life;Chronic;Circulation;cohort;Colon;Color;comorbidity;Cross-Sectional Studies;cytokine;Cytometry;cytotoxicity;Data;Data Analyses;Data Set;Dementia;detection assay;Development;Disease;Elderly;Ensure;Epithelial Cells;Epithelium;Exhibits;experimental study;Exposure to;Flow Cytometry;frailty;gastrointestinal;Gastrointestinal tract structure;Geriatric Assessment;Glean;HIV;HIV Enteropathy;HIV Infections;human old age (65+);Image;Immune;In Vitro;in vitro Assay;Individual;Inflammaging;Inflammation;Inflammatory;inflammatory marker;inhibitor;innovation;insight;intestinal barrier;intestinal epithelium;Intestinal permeability;Intestines;Introns;latent HIV reservoir;Link;Longitudinal Studies;Malignant Neoplasms;Marker Discovery;Measurement;Measures;microbial products;monolayer;mortality;Movement;multiplex detection;Multivariate Analysis;normal aging;novel;novel therapeutic intervention;novel therapeutics;Older Population;Osteoporosis;Outcome;Outcome Measure;Pathologic Processes;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Plasma;Population;prevent;prospective;Proteomics;receptor;Reporting;response;RNA;Role;Sampling;Site;Small Intestines;Sorting;Stroke;systemic inflammatory response;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Tight Junctions;Tissues;Viral;Viral Load result;Visualization;γδ T cells

PROJECT_TITLE: Gamma delta T cells promote inflammation in aviremic HIV infection and normal aging

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE This work will test the novel hypothesis that epigenetic changes regulating pluripotency and differentiation of male germ cells occur in association with the inner nuclear membrane (INM) and are facilitated by cell cycle arrest and by the RNA binding protein (RBP) Dead End 1 (DND1). We have shown that DND1 binds multiple epigenetic regulators, and we hypothesize that it controls their transcript levels and gates their translation during cell cycle arrest. Integrating RBP-mediated epigenetic reprogramming and cell cycle regulation into a unifying theoretical concept would establish a new paradigm and provide insights into the process of male gametogenesis.

PI_NAMEs: CAPEL, BLANCHE  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Actins;Address;Adult;Affect;Antibodies;ATAC-seq;Binding;Biological Assay;Cell Cycle Arrest;Cell Cycle Regulation;Cells;Chimeric Proteins;Chromatin;Chromatin Structure;Clone Cells;Data;Development;Disease;Dissociation;DNA Methylation;DNA Modification Methylases;Enzymes;Epigenetic Process;epigenetic regulation;epigenome;Gametogenesis;Gelatin;Genetic Transcription;Genus Mentha;Germ Cells;Gonadal structure;Heterogeneity;histone modification;Histones;Hour;Image;Immunoprecipitation;In Situ;in vivo;Individual;insight;Knowledge;Label;Lamins;lens;loss of function;Maintenance;male;male fertility;Maps;Mediating;Messenger RNA;Methylation;Mitotic;novel;Nuclear Envelope;Nuclear Inner Membrane;Nuclear Lamin;Nuclear Lamina;Pathway interactions;Pattern;Physiological;pluripotency;Population;Post-Transcriptional Regulation;Process;Proteins;Reporter;RNA;RNA Stability;RNA-Binding Proteins;Role;scaffold;Slide;Spermatocytes;stem cell fate;stem cell population;stem cells;subfertility;Teratoma;Tertiary Protein Structure;Testing;Time;Transcript;transcriptome;transcriptome sequencing;transdifferentiation;Transgenic Mice;Translating;Translations;Western Blotting;Work

PROJECT_TITLE: DND1 Mediates Epigenetic Reprogramming During Cell Cycle Arrest In Male Germ Cells

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ORG_CITY: CHICAGO

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

PHR: Project Narrative The Center for Smart use of Technologies for Assessment of Real-world Outcomes (C-STAR) addresses a pressing need within the rehabilitation research community for appropriate, accurate, and clinically meaningful use of available technologies—including sensors, mobile phones, smart-watches, and robots—to assess disease progression, treatment response or compliance, and patient-centered outcomes in real-world settings, e.g., the home, work/school, and community. We will support studies, mentored collaborations, and didactic interactions that promote use of technologies for assessment in the laboratory, clinic, and community. Our four Cores—Engineering, Clinical, Outcomes, and Implementation Science/Community Engagement—will provide expertise to (i) standardize use of such technologies, (ii) customize, validate, and calibrate technologies, and (iii) interpret collected data in the context of the needs and abilities of specific patient populations.

PI_NAMEs: LIEBER, RICHARD L. (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Address;Applications Grants;Area;Biomedical Engineering;Calibration;Cellular Phone;Chicago;Client;Clinic;Clinical;clinically relevant;cohort;Collaborations;Communities;community engagement;Data;Databases;design;Disabled Persons;Disabling condition;Disease Progression;Economics;Educational process of instructing;Elements;Engineering;Environment;Evidence based practice;experience;experimental study;Feedback;Funding;Goals;Grant;Home;Hospitals;Human;implementation science;Individual;Individuals with physical disabilities;Infrastructure;insight;Institution;Instruction;Intervention;Kinesiology;Laboratories;Learning;Letters;Level of Evidence;Life;Measures;Mechanics;Mentors;Mentorship;Methodology;Network Infrastructure;Neurosciences;new technology;novel;operation;Outcome;Outcome Measure;Patient Outcomes Assessments;patient population;Patient-Focused Outcomes;Patients;Performance;Physical Medicine;Physical therapy;Physiology;Pilot Projects;Process;programs;Proliferating;Publications;R24;rehabilitation research;rehabilitation science;Rehabilitation therapy;Research;Research Infrastructure;Research Personnel;Resources;Robot;sabbatical;Schools;Scientist;Seasons;Senior Scientist;sensor;smart watch;Standardization;Technology;Technology Assessment;technology validation;Testing;Time;Translational Research;treatment adherence;treatment response;United States National Institutes of Health;Universities;Veterans;Visit;web site;webinar;Work

PROJECT_TITLE: Center for Smart Use of Technology to Assess Real-world Outcomes (C-STAR)


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

PI_NAMEs: BAGDY, REBECCA  (contact)

PROJECT_TERMS: Academy;Accreditation;Address;American;Archives;Area;arm;Brain Injuries;Budgets;Clinic;Clinical;Communities;Congresses;Continuing Education;cost effective;Data Analyses;design;Development;Devices;Distance Learning;E-learning;Education;education planning;Educational Activities;Ensure;Event;experience;Feedback;flexibility;Grant;Home;improved;Knowledge;Learning;learning materials;learning strategy;Measures;meetings;mobile application;Musculoskeletal;Needs Assessment;online course;online repository;Outcome;Outcome Measure;Participant;patient population;Patient Selection;Patients;Performance;Persons;Physical Medicine;podcast;Process;programs;rehabilitation research;Rehabilitation therapy;Research;Research Activity;Research Personnel;Resources;Scientist;sensor;Series;simulation;Site;Spinal cord injury;Stroke;symposium;Technology;Technology Assessment;technology validation;Training;Training Activity;Training and Education;Universities;Update;webinar

PROJECT_TITLE: Center for Smart use of Technologies for Assessment of RealworldOutcomes (C-STAR)


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Health Services;Neurosciences;Physical Rehabilitation;Rehabilitation

PI_NAMEs: HEINEMANN, ALLEN WALTER (contact)

PROJECT_TERMS: Achievement;Agreement;Aphasia;Applications Grants;arm;Award;Biology;Bionics;career;career development;Cell Therapy;Child;Client;Clinical;Clinical Sciences;Cognition;Collaborations;Communication impairment;Compensation;Cost Sharing;Development Plans;disability;Disparity population;Educational Curriculum;Engineering;Evaluation;experience;Faculty;Financial Support;Funding;Funding Mechanisms;Goals;graduate student;Grant;Hand;hands on research;Health Services Research;Hispanic;Historically Black Colleges and Universities;Home;Housing;Human;Human Resources;Incentives;Independent Living;Individual;Institution;Laboratories;Learning;Leg;Locomotion;Logistics;Mediation;Medical Students;Medicine;member;Mentors;Mentorship;minority scientist;Modeling;Motor;muscle physiology;Native Americans;neural;Neurologic;neurological rehabilitation;neuromuscular function;Orthotic Devices;Outcome;Outcomes Research;Patients;Pediatrics;Performance;Physicians;Pilot Projects;Policies;Postdoctoral Fellow;Principal Investigator;Prosthesis;R24;recruit;regenerative;Rehabilitation Centers;rehabilitation engineering;Rehabilitation Outcome;rehabilitation research;rehabilitation technology;Rehabilitation therapy;Research;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;robot rehabilitation;sabbatical;Scientist;Self-Help Devices;Senior Scientist;Services;Site;skills;Specific qualifier value;Structure;summer internship;Technology;Time;Training;Training Programs;Translational Research;Travel;undergraduate student;United States;United States National Institutes of Health;Universities;Upper Extremity;Visit;Walking;Woman;Work;Writing

PROJECT_TITLE: Collaboration and Opportunities Component


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: Project Narrative Lung squamous cell carcinoma (LUSC) is a major form of lung cancer with poor prognosis and limited treatment options. This project will: 1) assess the efficacy of novel drug combination strategies that target three cancer-causing genetic drivers of LUSC; and 2) characterize tumor initiation and progression in a new pre- clinical mouse model of LUSC. These studies will facilitate development of new therapies to improve treatment of LUSC and identify biomarkers to predict LUSC progression and response to therapy.

PI_NAMEs: FIELDS, ALAN P. (contact);JUSTILIEN, VERLINE

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: 3q26;Alleles;Auranofin;Biochemical;Biogenesis;Bioinformatics;Biology;biomarker identification;cancer diagnosis;Cancer Etiology;cell growth;Cell Line;cell transformation;Cells;Cessation of life;Characteristics;Chromosomes;Clinical;clinically relevant;Collaborations;Combined Modality Therapy;conditional knockout;Data;design;Development;Diagnosis;Drug Combinations;druggable target;early detection biomarkers;efficacy evaluation;Enterobacteria phage P1 Cre recombinase;Erinaceidae;Event;Exhibits;Genes;Genetic;Genetic Engineering;Genetic Recombination;Genetic Transcription;Genetically Engineered Mouse;Genomics;Growth;Histologic;Human;improved;improved outcome;In Vitro;in vivo;inhibitor;Keratin;Knock-in;Knowledge;Lesion;Lung;Lung Adenocarcinoma;lung lesion;Lung Neoplasms;Malignant - descriptor;Malignant Epithelial Cell;Malignant neoplasm of lung;Malignant Neoplasms;MEKs;Modeling;Molecular;Morphology;mouse model;Mus;Mutation;Neoplasm Metastasis;neoplastic;neoplastic cell;new therapeutic target;Non-Small-Cell Lung Carcinoma;notch protein;novel;novel drug combination;novel therapeutic intervention;novel therapeutics;Oncogenic;Outcome;overexpression;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacodynamic biomarker;pharmacologic;Phenotype;Phosphorylation;pre-clinical;predictive marker;premalignant;Prognosis;programs;Proliferating;promoter;Proteins;recombinant adenovirus;Recurrence;Resources;response;Ribosomal DNA;Ribosomal RNA;Ribosomes;self-renewal;Signal Transduction;small molecule inhibitor;Specific qualifier value;Squamous Cell Lung Carcinoma;stem cells;Testing;Therapeutic;TP53 gene;Transgenes;treatment response;tumor;tumor growth;tumor initiation;tumor progression;tumorigenesis;United States;World Health Organization

PROJECT_TITLE: A Genetically Tractable Mouse Model for PRKCI-driven Lung Squamous Cell Carcinoma

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Stroke;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PI_NAMEs: JAYARAMAN, ARUN  (contact)

PROJECT_TERMS: Acceleration;Address;Algorithms;Amputation;Android;Area;Arthritis;Benchmarking;Biochemical;Biological Markers;biomechanical test;Biosensing Techniques;Brain Injuries;Calibration;Caring;Categories;Cellular Phone;chronic pain;Chronic stress;Client;Clinic;Clinical;Cognitive;cohort;Collaborations;Collection;Communities;Computers;Data;Data Analyses;Data Collection;data standards;Databases;Devices;Disabled Persons;Elderly;electronic sensor;Electronics;Engineering;experience;experimental study;flexibility;Focus Groups;Goals;Health;Hydration status;Hydrocortisone;Impairment;improved;Individual;Institution;Internet;Intuition;Label;Laboratories;laptop;light weight;Location;Malignant Neoplasms;Measurement;Measures;Mechanics;Microfluidics;mobile application;Monitor;Movement;Musculoskeletal;Neuromuscular conditions;new technology;Occupations;older adult;Operating System;Outcome;Outcome Measure;Parkinson Disease;Patients;Performance;Persons;Physical Medicine;Physical Performance;Physiological;Physiology;Pilot Projects;Population;prediction algorithm;Preparation;Protocols documentation;Rehabilitation Outcome;rehabilitation research;rehabilitation technology;Rehabilitation therapy;research and development;Research Personnel;Resources;sabbatical;Scientist;Semiconductors;sensor;sensor technology;Site;Skin;smart watch;Spinal cord injury;Spinal Injuries;Standardization;Stress;Stroke;stroke survivor;System;Tablets;technique development;Technology;technology development;temporal measurement;Testing;Thinness;Traumatic Brain Injury;Traumatic Brain Injury recovery;Vestibular Diseases;wireless;Work

PROJECT_TITLE: Collaboration with Other Institutions Component


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Diabetes;Endocrine Disruptors;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The prevalence of type 2 diabetes and its severe complications have been rising in the U.S. and globally. The goal of this research is to determine the effects of exposure to the widely used per- and poly-fluoroalkyl substances and other environmental chemicals on developing type 2 diabetes in multi-ethnic adult populations, using novel metabolomic and genomic approaches. Findings will inform precision medicine approaches for the prevention and treatment of type 2 diabetes.

PI_NAMEs: VALVI, DAMASKINI  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: adipokines;Adult;Affect;African American;African American population;Age;American;Amino Acids;analytical method;Beta Cell;biobank;Biometry;Blood;Carbohydrate Metabolism Pathway;Chemical Exposure;Chemicals;Clinical;cohort;Cohort Studies;Data;data integration;design;Development;Diabetes prevention;diabetes risk;diabetogenic;Diagnosis;Diagnostic;Disparity;early detection biomarkers;Early identification;Electronic Health Record;Endocrine Disruptors;environmental chemical;Enzymes;Epidemic;ethnic disparity;ethnic diversity;ethnic minority;Ethnic Population;Etiology;European;European ancestry;experience;Exposure to;Functional disorder;gene environment interaction;Genes;Genetic;genetic epidemiology;Genetic Predisposition to Disease;genetic risk factor;Genetic Variation;Genome;Genomic approach;Genomics;Glucose;Goals;Hawaii;Health;high risk;Hispanic;Hispanic Populations;Hospitals;Impairment;Individual;innovation;Insulin Resistance;Investigation;life span;Life Style;Link;Lipids;Liver;Longitudinal cohort;Los Angeles;Low Birth Weight Infant;Measures;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methods;modifiable risk;Modification;multi-ethnic;multidisciplinary;Nested Case-Control Study;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Outcome;Participant;participant enrollment;Patient Self-Report;Phenotype;phenotypic data;physical inactivity;Plasma;Poly-fluoroalkyl substances;polygenic risk score;Population;population based;Population Control;Population Heterogeneity;precision medicine;Prediabetes syndrome;Prevalence;prevent;Prevention approach;Primary Care;prospective;Prospective Studies;racial disparity;Research;Research Personnel;Resolution;Resources;Risk;Risk Factors;Sampling;Seasons;sex;synergism;Time;Unhealthy Diet

PROJECT_TITLE: Perfluoroalkyl substances and incident type 2 diabetes in a multi-ethnic population: A metabolome-genome investigation

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Neurosciences;Physical Rehabilitation;Rehabilitation

PI_NAMEs: CHERNEY, LEORA R (contact)

PROJECT_TERMS: Address;Advertising;Applications Grants;Award;Budgets;Career Mobility;career networking;Clinic;Clinical;clinical implementation;Clinical Sciences;clinically relevant;Communication;community engagement;Computer software;Country;Data;Data Analyses;Databases;Development;Direct Costs;Doctor of Philosophy;Engineering;Ensure;Experimental Designs;Extramural Activities;Facilities and Administrative Costs;Faculty;Feedback;Funding;Funding Agency;Future;Goals;Historically Black Colleges and Universities;Home;Human Resources;implementation science;improved;Individual;Institution;Internet;Letters;Life Cycle Stages;Link;Measures;meetings;member;Mentors;Mentorship;Methodology;Methods;Minority;Outcome;outreach;Patient Care;patient population;Patients;Pattern;Performance;Periodicals;Pilot Projects;Population;Process;programs;Publications;Qualifying;recruit;rehabilitation research;Rehabilitation therapy;Reporting;Research;Research Design;Research Personnel;Resources;sabbatical;Services;smart technologies;Surveys;System;Talents;Target Populations;Technology;technology validation;Time;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Update;web site

PROJECT_TITLE: Coordination Center Component


NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences

PI_NAMEs: OWENS, BETSY  (contact)

PROJECT_TITLE: Didactic Interactions Component


PROJECT_TERMS: Accounting;Address;Administrative Efficiency;Advisory Committees;Budgets;Collaborations;Communities;Consultations;Data;Databases;Devices;Disability outcome;Disabled Persons;Ensure;Environment;Evaluation;experience;Funding;Gender;Goals;Grant;Head;Housing;Human Resources;Hybrids;improved outcome;industry partner;Infrastructure;Institution;Leadership;Learning;Marketing;Measures;Mentors;Mentorship;Methods;Mission;Modeling;Monitor;new technology;novel;Online Systems;organizational structure;Outcome;Output;outreach;Persons;Physical Medicine;Physicians;Pilot Projects;Population Heterogeneity;Principal Investigator;Productivity;profession allied to medicine;Program Effectiveness;programs;rehabilitation research;Rehabilitation therapy;Research;Research Personnel;Resources;Scientist;social media;Structure;Study Section;success;Technology;technology development;Underrepresented Populations;Universities

PROJECT_TITLE: Pilot Studies Component


NIH_SPENDING_CATS: Genetics

PHR: PROJECT NARRATIVE  Homeostasis relies on precise and dynamic action by nuclear pathways including RNA transcription, DNA repair, and genome organization. While cooperative interactions between proteins and cofactors helps ensure selectivity, the events mediating the rapid action are less well understood. We believe molecular chaperones, especially the Hsp90 system, foster a highly dynamic nuclear environment that is critical for timely and effective DNA-associated pathways.

PI_NAMEs: FREEMAN, BRIAN C (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TITLE: Regulation of the Native Protein Landscape in the Nucleus by Molecular Chaperones

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Bioengineering;Health Effects of Indoor Air Pollution

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE When inhaled at high concentrations, carbon monoxide causes cardiac and neurocognitive deficits and death; however, when produced at low concentrations in tissue, carbon monoxide acts as an intracellular signal and has even been tested as a therapeutic agent. In this proposal, we aim to develop a microbial carbon monoxide sensor, RcoM, into (1) a fast-acting carbon monoxide scavenger that can serve as an antidote for carbon monoxide poisoning and (2) a sensitive detector of carbon monoxide in living cells. Development of these molecular therapeutics and tools will dramatically improve the current standard of care for carbon monoxide poisoning and advance our understanding of intracellular carbon monoxide signaling and toxicology, with the potential to substantially decrease death and disability caused by this common poisoning.

PI_NAMEs: DENT, MATTHEW RYAN (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acute;Address;Affinity;Amino Acids;Antidotes;Binding;Biological;biophysical chemistry;Biosensor;Calibration;Carbon Monoxide;Carbon Monoxide Poisoning;Cardiac;career;cell growth;Cells;Cessation of life;chemical stability;Chemicals;circadian regulation;Clinical;Clinical Research;conventional therapy;CRISPR/Cas technology;Cytoprotection;design;Detection;detector;Development;Diagnosis;disability;Disease;Emergency department visit;Erythrocytes;Exhibits;experience;Fluorescence;Functional disorder;Health;Heme;Hemeproteins;hemodynamics;Hemoglobin;Human;improved;In Vitro;in vivo;induced pluripotent stem cell derived cardiomyocytes;Infection;Inflammation;Inhalation;innovation;Inorganic Chemistry;insight;Intravenous;Intravenous infusion procedures;Ischemia;Kinetics;Learning;Ligands;long-term sequelae;Mammalian Cell;Mentorship;Metabolism;Methods;microbial;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;mouse genome;mouse model;Mus;Neurocognitive;Neurocognitive Deficit;Organ;organ injury;organ transplant rejection;Organism;Outcome;Oxygen;Patient-Focused Outcomes;Patients;Pattern;Persons;Physiological;point of care;Poisoning;pre-clinical;preclinical study;pressure;prevent;Production;Proliferating;Property;Recombinants;Reperfusion Injury;Reporter;Reporter Genes;Research Personnel;response;Role;Safety;safety assessment;scaffold;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;skills;Spectrophotometry;standard of care;Survivors;Testing;Therapeutic;Therapeutic Agents;Tissues;tool;Toxic effect;Toxicology;transcription factor;Transfection;Transgenic Organisms;United States;Variant

PROJECT_TITLE: Optimization of a carbon monoxide (CO) sensing hemoprotein for applications as an antidote for CO poisoning and a biosensor for CO detection in living cells

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Neurosciences;Physical Rehabilitation;Rehabilitation

PI_NAMEs: DEWALD, JULIUS P (contact)

PROJECT_TERMS: Affect;Appointment;Area;Assessment tool;Biomedical Engineering;bridge program;Client;Clinic;Clinical;clinical practice;Cognitive deficits;cognitive function;cognitive rehabilitation;Cognitive Science;Collaborations;commercialization;Communication;Communities;community engagement;Complement;Data;Data Analyses;design;Development;disability;Disease;Engineering;experience;Faculty;Feedback;Foundations;Functional disorder;Funding;Goals;Healthcare;Human;Human Resources;Impaired cognition;implementation science;Industry;industry partner;innovation;Institution;instrument;interest;Kinesiology;Knowledge;Leadership;Measurement;Measures;Mechanics;Medical;Medicine;Mentorship;Mission;Nature;Neighborhood Health Center;Outcome;Outcome Measure;Participant;patient population;Patients;Performance;Physical Medicine;Physical Rehabilitation;Physical therapy;Population;Population Heterogeneity;programs;rehabilitation research;rehabilitation science;Rehabilitation therapy;Research;Research Personnel;Resources;sabbatical;Schools;Science;Scientist;sensor;Sensorimotor functions;social;Social Sciences;Speed;statistical learning;Technology;Technology Assessment;technology development;Testing;tool;Training;Translating;Translational Research;Universities

PROJECT_TITLE: Technology Development Component